SGTCid condition conc unit BUD31|YCR063W.score BUD31|YCR063W.strain.pval BUD31|YCR063W.strain.significant BUD31|YCR063W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 9.37567603918088 1.13514684438845e-22 yes 1 3.43669319998953e-21 7 91467 include heat shock
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 9.2794545961699 2.99417006358646e-22 yes 2 8.51741478792061e-21 6 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 7.87073522195281 1.44423640826836e-16 yes 3 1.76281553753212e-15 7 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 7.73286361329989 4.64843081267822e-16 yes 4 5.25769683743482e-15 19 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 7.58730112448623 1.56283510649215e-15 yes 5 1.63318698119598e-14 11 368090
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 6.94114278115061 2.60232049773619e-13 yes 6 1.94470327312018e-12 10 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_453 enantio-paf c16 10 µM 6.89616290492249 3.65549471617103e-13 yes 7 2.67129636116198e-12 26 13871343 A lipid and platelet activating factor
SGTC_117 lucigenin 22.078 µM 6.84680351230372 5.29475812804771e-13 yes 8 3.77591636914972e-12 31 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_422 cantharidin 155 µM 6.14921186352465 7.5841077998494e-11 yes 9 3.8934453720719e-10 18 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1597 7-benzyloxygramine 47.5 µM 5.61289960508468 2.44394721346718e-09 yes 10 9.94820233569678e-09 56 260807
SGTC_502 l-744,832 89.3 µM 5.47606481302206 5.65142978013151e-09 yes 11 2.17444228657099e-08 14 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_451 chloral hydrate 100 µM 5.19754466279403 2.93239736424474e-08 yes 12 1.00969015858589e-07 23 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_58 0957-0393 9 µM 5.10349147345185 5.02153259636163e-08 yes 13 1.66721771515269e-07 274 6997992
SGTC_715 0868-0130 184 µM 5.06675251710198 6.18036677173115e-08 yes 14 2.02329915958581e-07 5 2876258
SGTC_2582 agaric acid 100 µM 4.70999613365451 4.31832271347763e-07 yes 15 1.23860745360337e-06 241 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_697 0508-1955 564 µM 4.6619331563435 5.55544727155171e-07 yes 16 1.56626470634057e-06 20 6243113
SGTC_351 caspofungin 25 nM 4.56103791939221 9.3548258978194e-07 yes 17 2.54506934584646e-06 69 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_138 0850-0259 40.9225 µM 4.27625530456614 3.84955869885047e-06 yes 18 9.50316245645733e-06 176 6813004
SGTC_202 3594-0513 34.79 µM 4.26512920295878 4.06147007822814e-06 yes 19 9.98932772262152e-06 7 708429
SGTC_1873 rapamycin 2 nM 4.16045507760906 6.68258102815081e-06 yes 20 1.58807043850124e-05 64 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1712 st032288 53.4 µM 4.10950388652882 8.4811924615028e-06 yes 21 1.98255020903448e-05 181 2883011
SGTC_744 1594-0068 283 µM 4.07450519383472 9.97460006497997e-06 yes 22 2.30561420974767e-05 23 668392
SGTC_2489 cantharidin 73.42 µM 4.00579548200275 1.36649256288727e-05 yes 23 3.09045564422323e-05 38 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2907 7721985 69.9 µM 3.97130208732968 1.59754541789024e-05 yes 24 3.57404350016497e-05 22 3267881
SGTC_309 k408-0051 1.48 µM 3.9310915206998 1.91373609364158e-05 yes 25 4.22805359684664e-05 46 3640463
SGTC_720 r052-1644 49.9 µM 3.90954621955915 2.10674481460529e-05 yes 26 4.62348311214449e-05 24 1422863 YOR257W CDC31
SGTC_467 ro 31-8220 72.8 µM 3.88693943412952 2.32904509524238e-05 yes 27 5.07580349516966e-05 81 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_118 0083-0097 135.343 µM 3.74457854437624 4.32869965301809e-05 yes 28 9.03484215624282e-05 158 5207356
SGTC_2777 climbazole 1.536 µM 3.71483393607443 4.91444487929754e-05 yes 29 0.000101668592632821 61 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_726 3448-4391 34.2 µM 3.55487401187372 9.57698664868e-05 yes 30 0.000189080123130853 22 1356692
SGTC_1066 ketoconazole 628 nM 3.51131218679743 0.000114339726704838 yes 31 0.000222950208256521 38 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1476 4112-3294 3.34 µM 3.49757091253286 0.000120866011426626 yes 32 0.000234757936286657 32 704369
SGTC_1917 st066507 28.5 µM 3.48792481534823 0.000125654363793485 yes 33 0.000243392470259986 59 3156428
SGTC_2422 chlorphenesin carbamate 384.24 µM 3.408343263741 0.000172518464847835 yes 34 0.0003267931010744 54 2724 A muscle relaxant with antifungal properties.
SGTC_864 0469-0573 172 µM 3.28995279775869 0.000273223470121869 yes 35 0.000501020953188612 42 689425
SGTC_1064 honokiol 6.76 µM 3.28695616360138 0.000276371426551653 yes 36 0.000506382988864413 46 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 3.22393977207805 0.000350923370334583 yes 37 0.000632199946772093 53 6312947
SGTC_1752 st044819 83.042 µM 3.21683809897939 0.000360406762827928 yes 38 0.000648058585685182 49 441209 YML126C ERG13
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 3.19400911920091 0.000392529058515357 yes 39 0.0007015584249205 35 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2688 kanamycin b 96.69 µM 3.17070695164558 0.000428041908532361 yes 40 0.000760342341325596 500 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1310 1188-0297 994 nM 3.15733022921183 0.000449751683659374 yes 41 0.000796104602201778 65 1588352
SGTC_2024 5144227 134 µM 3.07913649836387 0.000598443562237202 yes 42 0.00103800770332552 80 3475211
SGTC_163 TUB2.036 7.546 µM 3.04837182211311 0.000668506209665283 yes 43 0.0011504252259983 178 15992207 YJR013W GPI14
SGTC_1382 3002-2117 298 µM 3.02922039751392 0.000715864751554066 yes 44 0.0012259287088382 42 1497314
SGTC_3210 9128157 49.47 µM 3.00485541600346 0.000780584618351718 yes 45 0.0013285356110399 104 17590849
SGTC_2980 9014342 25.29 µM 3.00439609477528 0.000781854874141309 yes 46 0.00133054317771885 81 2996599
SGTC_2405 ticlatone 3.52 µM 2.97525517295475 0.000866445939793205 yes 47 0.00146372461643669 131 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1722 st034304 3.6505 µM 2.97060655475106 0.000880693457933304 yes 48 0.00148606140113948 90 4036148 YLR033W RSC58
SGTC_2619 obliquin 87.91 µM 2.96976436553865 0.00088329760869192 yes 49 0.00149014127295829 222 6708593 A bioactive alkalod. YER133W GLC7
SGTC_831 k061-1017 217 µM 2.9682393134438 0.000888031277410287 yes 50 0.00149755519887026 132 1240153
SGTC_1624 st003710 6.25 µM 2.9321336584289 0.00100714170938422 no 51 0.00168320915170885 99 24207033
SGTC_408 cantharidin 100 µM 2.92557270093623 0.00103029921718051 no 52 0.00171911414645891 70 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_638 3970-0837 4.09 µM 2.91510246154669 0.00106826852610998 no 53 0.00177785892233297 94 4118451 YLR208W SEC13
SGTC_2402 5553605 200 µM 2.89522913375015 0.00114388688352948 no 54 0.00189440929224332 90 6758546
SGTC_797 k781-0471 270 µM 2.89392796899934 0.001149004902648 no 55 0.0019022771403626 63 23738129
SGTC_1479 0549-0158 134 µM 2.87898250289836 0.0012093144917326 no 56 0.00199480234107722 83 5440202
SGTC_3201 9113999 49.47 µM 2.86034993079725 0.00128855655187017 no 57 0.00211586890856897 90 16649224
SGTC_356 1634-0012 32.5 µM 2.85991302507652 0.00129047036546002 no 58 0.00211878604633412 80 735457
SGTC_1223 0764-0573 147 µM 2.85916630867847 0.00129374728604372 no 59 0.00212378017791251 75 1609797
SGTC_2263 7948595 193.29 µM 2.84580117843127 0.00135370097430497 no 60 0.00221499224497721 42 2971371
SGTC_1337 1486-1011 40.3 µM 2.84420678478487 0.00136102014570453 no 61 0.00222610715191219 66 X1337
SGTC_708 3448-5400 146 µM 2.83086667093864 0.00142369033119529 no 62 0.00232110338752853 111 3462195
SGTC_3283 9109332 35.8195 µM 2.78233510161016 0.00167455447245642 no 63 0.00269846416469677 57 17027281
SGTC_1093 fluphenazine 7.97 µM 2.76481629746703 0.00177457658450442 no 64 0.0028477430208176 81 6602611 An atypical antipsychotic.
SGTC_187 1488-2104 32.728 µM 2.75426151564526 0.00183743188302467 no 65 0.00294123718071113 92 2852859
SGTC_582 0987-0078 156 µM 2.74506747219676 0.0018938261629159 no 66 0.00302492289299434 179 1625765
SGTC_2028 5153890 36.43 µM 2.72320921856977 0.00203426816469147 no 67 0.00323255504124742 90 2830968 YPR165W RHO1
SGTC_1276 0871-0068 94.2 µM 2.71638315177206 0.0020800251951798 no 68 0.00329997439724201 73 3414906
SGTC_1149 3909-7961 23.3 µM 2.70257164301195 0.00217547513504893 no 69 0.0034402677315795 108 735261
SGTC_1306 1185-0270 9.02 µM 2.69323886863082 0.00224220289394908 no 70 0.00353807760033306 117 1548076
SGTC_2999 9069765 71.4286 µM 2.64247856365144 0.00263868808622732 no 71 0.00411508374631828 116 2097066
SGTC_350 k064-0020 19.8 µM 2.60115139484303 0.00300711724563137 no 72 0.00464557205229897 120 2790705
SGTC_273 hydroxyurea 18.1 mM 2.58645143123859 0.00314894864667224 no 73 0.00484849177554947 118 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_801 0866-0028 10.1 µM 2.58508623788105 0.00316242144096854 no 74 0.00486773219078584 136 6849771
SGTC_2776 terbinafine 19.92 µM 2.58173144874962 0.00319574977051305 no 75 0.00491530244703024 133 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1038 k292-0204 154 µM 2.5816723976599 0.00319633923670992 no 76 0.00491614347703189 85 4454212
SGTC_2915 7971052 15.16 µM 2.5656896838086 0.0033595271498225 no 77 0.00514854516924888 54 5741558
SGTC_2572 astragaloside iv 100 µM 2.55649858987739 0.00345672652221615 no 78 0.00528657498092667 122 45006101 An anti-inflammatory agent.
SGTC_2313 7726885 200 µM 2.53986731468695 0.00363904991873465 no 79 0.0055447265384339 120 726423
SGTC_1121 fusaric acid 630.51 nM 2.53031312599161 0.00374764914165075 no 80 0.00569803865763191 128 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_3295 9122362 53.5725 µM 2.49368543307907 0.00419141299118737 no 81 0.0063212264723526 100 4730473
SGTC_3050 9093513 49.47 µM 2.47284209910829 0.00446441239091132 no 82 0.00670216765400087 99 25236664
SGTC_2810 7959871 45.46 µM 2.41556200512716 0.00529820618319771 no 83 0.00785547363622158 169 2974535
SGTC_65 0798-0905 34.986 µM 2.39852470299319 0.00557161153381793 no 84 0.00823063305525376 257 3602145
SGTC_1463 k081-0032 34.1 µM 2.39759195706152 0.00558693521911742 no 85 0.00825161899363068 72 977755
SGTC_800 3448-7362 155 µM 2.39274624548577 0.00566714725951024 no 86 0.00836140114619638 399 15991913
SGTC_1122 capsaicin 818.572 nM 2.38073009120538 0.00587048058738712 no 87 0.00863918335715022 137 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_285 1486-1325 46 µM 2.38022965636666 0.00587908740161196 no 88 0.00865092564531422 114 22310230
SGTC_1385 3091-4834 14.1 µM 2.37492154596139 0.00597107112911781 no 89 0.00877634027112422 114 4072814
SGTC_1960 st011366 51.8 µM 2.36498613200264 0.00614667573084562 no 90 0.0090153730461406 92 3972846
SGTC_2302 7771753 200 µM 2.36020742498587 0.00623275552032699 no 91 0.00913235964023831 191 2203047
SGTC_1459 k035-0031 35.7 µM 2.35999375858114 0.0062366291467813 no 92 0.0091376212657737 111 3877128 YMR208W ERG12
SGTC_2431 5490079 200 µM 2.35188089023638 0.00638529610252773 no 93 0.0093393775332743 165 5722345
SGTC_2736 butenafine 14.65 µM 2.34383951432313 0.00653573930671935 no 94 0.00954319102940103 170 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1863 st057641 20.1 µM 2.33043375621613 0.00679351995153875 no 95 0.00989161869759371 138 3921635
SGTC_1683 st010134 710 nM 2.29571357057607 0.00750336106036171 no 96 0.0108461320030753 176 3818134
SGTC_698 k064-0052 127 µM 2.29538599971618 0.00751035811136291 no 97 0.010855506486562 68 5088751
SGTC_2658 polymyxin b sulfate 77.05 µM 2.29111757861616 0.0076020601572818 no 98 0.0109783071094114 176 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_884 0851-0618 334 µM 2.28321724973507 0.00777439348202862 no 99 0.0112087872609427 155 9642473
SGTC_830 4076-0286 57.8 µM 2.2825084040492 0.00779002261432712 no 100 0.0112296709424361 296 6866659
SGTC_258 haloperidol 50.781 µM 2.27646976782305 0.00792429154058982 no 101 0.0114089540334864 197 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2235 salicylic acid 500 µM 2.27386412758358 0.00798285367588291 no 102 0.0114870785582953 77 338 A COX inhibitor and kinase inhibitor.
SGTC_245 methotrexate 289.6 µM 2.27041996380184 0.00806084547496921 no 103 0.0115910571684508 178 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_874 0599-0792 117 µM 2.26956419240635 0.00808032767345279 no 104 0.0116170191405379 175 765305
SGTC_2236 dapsone 200 µM 2.26375683940063 0.00821363260193903 no 105 0.0117945372248673 146 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2348 9022543 33.42 µM 2.26198541934616 0.00825467737736585 no 106 0.0118491520804515 161 3162678 YDL140C RPO21
SGTC_1339 1486-1321 22.7 µM 2.25512461922754 0.00841535080527868 no 107 0.0120627538671614 156 3469382
SGTC_1959 st077091 55.8 µM 2.25152419278434 0.0085007627037689 no 108 0.0121761781841319 186 821356 YKL052C ASK1
SGTC_471 1-acyl-paf 4 µM 2.2467788497696 0.00861449662813337 no 109 0.0123270820509099 151 16759367
SGTC_2435 5706476 10.6 µM 2.24127462575362 0.00874808912763396 no 110 0.0125041457661088 177 5725375
SGTC_881 0833-0569 170 µM 2.23609008377967 0.00887558029769355 no 111 0.0126729354383762 175 5418700
SGTC_1574 spiramycin 23.7 µM 2.22731885072334 0.00909498014475656 no 112 0.0129629857762801 182 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_548 1436-0017 110 µM 2.22372669747781 0.00918619448286278 no 113 0.0130834189319872 203 9677137
SGTC_2254 7938975 95.19 µM 2.21960400556568 0.00929186661650815 no 114 0.0132228300697118 211 2969277
SGTC_1622 st003707 19.4 µM 2.21404152224976 0.00943612813518073 no 115 0.0134129613641674 222 10140899
SGTC_2137 5261020 140 µM 2.21390712385901 0.00943963782334597 no 116 0.0134175842944883 175 763655
SGTC_1362 1611-0397 101 µM 2.19795155157493 0.00986450042397162 no 117 0.0139762793246323 159 27816
SGTC_40 0327-0103 19.753 µM 2.17258695143889 0.0105742962874831 no 118 0.0149057094241985 204 409036
SGTC_3254 9136651 49.47 µM 2.16803617799627 0.0107062458789695 no 119 0.0150779670204838 168 16454030
SGTC_3244 9134489 49.47 µM 2.15605529475954 0.0110605092597863 no 120 0.0155396738653589 174 16584271
SGTC_3314 9135860 59.4275 µM 2.15285963099416 0.0111567075249884 no 121 0.0156648559848908 157 25252478
SGTC_1524 corynanthine 62.1 µM 2.15089613635281 0.0112161742413396 no 122 0.0157421992870377 178 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1108 betulinic acid 729.144 nM 2.15077535393155 0.0112198412570239 no 123 0.0157469676594019 172 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1164 k060-0068 93.7 µM 2.14930827220066 0.0112644658855422 no 124 0.0158049856057367 199 5963676
SGTC_3137 9097352 49.47 µM 2.14388308224211 0.0114308281096767 no 125 0.0160211280347168 237 44120435
SGTC_913 3487-1245 167 µM 2.14254170085345 0.0114722889030284 no 126 0.0160749583778834 215 4016153
SGTC_1376 2910-0861 41.3 µM 2.13373248179313 0.0117478328989623 no 127 0.0164323427864877 210 1112859
SGTC_93 0109-0045 59.227 µM 2.1276904295559 0.0119401270288255 no 128 0.0166813794690873 228 88733
SGTC_2788 5282734 71.43 µM 2.12572650825642 0.0120032158553182 no 129 0.0167630191960601 228 743706
SGTC_1275 0867-0008 21.1 µM 2.12496941258302 0.0120276138131093 no 130 0.0167945826270957 185 3422836
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 2.12029958313117 0.0121790551434351 no 131 0.0169903944040948 187 75037 A free radical scavenger.
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 2.10769589718458 0.0125960657373692 no 132 0.0175286512151083 144 61125 An anti-inflammatory.
SGTC_1254 0550-0035 264 µM 2.10469323289299 0.0126972170002662 no 133 0.0176590099638483 196 15121435
SGTC_1807 st050092 58.9 µM 2.10335442432585 0.012742543766005 no 134 0.0177173996317965 192 5008496
SGTC_233 rapamycin 362 pM 2.10329412488105 0.0127445885574116 no 135 0.0177200333532876 165 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_289 k017-0060 526 µM 2.10209641729347 0.0127852624229428 no 136 0.0177724153330661 152 5512909
SGTC_1916 st067606 49.2 µM 2.09591504016288 0.0129969705858261 no 137 0.0180448641385661 242 19590279
SGTC_2962 9082311 13.18 µM 2.09346654435678 0.0130816642295169 no 138 0.0181537637774335 181 16459453
SGTC_816 0325-0417 81.3 µM 2.07244692664011 0.0138285653764289 no 139 0.0191118904588869 175 68101
SGTC_2831 7999036 19.48 µM 2.06849462680788 0.013973038650782 no 140 0.0192967676757139 250 2988270
SGTC_629 3448-6466 76.7 µM 2.0628333278887 0.0141822489156841 no 141 0.0195642331879544 208 573744
SGTC_2630 antimycin a 100 µM 2.05796399198184 0.0143643459460029 no 142 0.0197967950345761 240 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2616 abietic acid 100 µM 2.05627660917464 0.0144279164734165 no 143 0.0198779307991495 228 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_3279 9140807 49.47 µM 2.0549083313865 0.0144796427185924 no 144 0.019943929803449 162 45595718
SGTC_371 0195-0006 7.36 µM 2.05135673136138 0.014614652614156 no 145 0.0201161097366467 172 3928593
SGTC_727 3032-0951 202 µM 2.04903214519396 0.0147036043478223 no 146 0.0202294858672159 197 3652836
SGTC_272 doxorubicin 8.13 µM 2.04733352113468 0.0147688974039726 no 147 0.0203126743755503 249 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1135 dihydrocapsaicin 536.708 nM 2.04326456898726 0.0149263179713563 no 148 0.0205131274864482 240 107982 A Capsaicinoid.
SGTC_739 1486-1183 203 µM 2.03628142507705 0.0151998464973784 no 149 0.0208610519718811 196 4346692
SGTC_2064 5220758 200 µM 2.02340210207658 0.0157156319227701 no 150 0.0215158538252325 252 788518
SGTC_2526 patulin 37.61 µM 2.01230136219452 0.0161721667440363 no 151 0.0220940894684891 329 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2917 7979103 53.79 µM 2.01090746682798 0.0162302880059157 no 152 0.0221676157623482 265 2980565
SGTC_959 1222-0044 107 µM 1.99691749159809 0.0168236052435303 no 153 0.0229170733616743 229 6083612
SGTC_31 0508-1974 57.237 µM 1.99373729163883 0.0169610364035779 no 154 0.0230903858710258 200 6810525
SGTC_735 3076-0345 636 µM 1.99183106289826 0.0170438725894238 no 155 0.0231947983935561 264 2888990
SGTC_2966 9084041 48.03 µM 1.99131191669444 0.0170664921888801 no 156 0.023223303081045 230 17741380
SGTC_645 0845-0943 5.41 µM 1.98484021463227 0.0173506296764828 no 157 0.0235811258555379 198 1885106
SGTC_154 3389-1638 511.116 µM 1.98232562620852 0.0174621165306085 no 158 0.0237214038403082 223 5238686
SGTC_2690 usnic acid 100 µM 1.9691229738788 0.0180575570365729 no 159 0.0244694856339934 258 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1365 1672-3266 55.4 µM 1.96504154976066 0.0182450969386536 no 160 0.0247047143736749 237 6415873
SGTC_1482 3346-2049 8.48 µM 1.96005771934362 0.0184763504010384 no 161 0.0249945221660709 216 3826804
SGTC_902 1120-0002 2.07 µM 1.95961857193386 0.0184968463071732 no 162 0.0250201944985081 277 3280475
SGTC_2320 7373003 200 µM 1.95706253549752 0.0186165264297221 no 163 0.0251700582333781 211 5415828
SGTC_489 paxilline 115 µM 1.95377739676099 0.018771312519428 no 164 0.0253637742544847 209 105008 A toxic potassium channel blocker.
SGTC_1656 st012921 11 µM 1.9524822715486 0.0188326352943445 no 165 0.0254404868756778 193 6732821
SGTC_2913 7966556 36.57 µM 1.94771251092532 0.0190599501620232 no 166 0.0257246861337078 190 2976516
SGTC_2178 5812956 200 µM 1.94382146582755 0.0192471116685443 no 167 0.0259584921312122 215 5403383
SGTC_569 4130-2812 160 µM 1.94371816729951 0.0192521015969329 no 168 0.0259647233007676 159 743552
SGTC_2274 7947094 46.08 µM 1.94137491602622 0.0193655901717705 no 169 0.0261064092871013 266 2971028
SGTC_439 amiodarone 34.4 µM 1.9400515649026 0.0194299336425834 no 170 0.0261867117471543 325 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_91 0417-1751 58.384 µM 1.93948365074733 0.0194576021914624 no 171 0.0262212367088536 316 6795624
SGTC_1019 4262-0212 3.4 µM 1.93255124885924 0.0197980526694113 no 172 0.0266457514842474 312 4677213
SGTC_344 k064-0035 6.43 µM 1.93076316562834 0.0198866812901281 no 173 0.0267561737230374 240 5088750
SGTC_728 3030-5151 22.5 µM 1.930139094093 0.0199176933459224 no 174 0.0267948028173192 207 3125388
SGTC_2183 6420625 130.508 µM 1.92451408465571 0.02019907393376 no 175 0.0271450885005545 325 2897619
SGTC_57 miconazole 162.5 nM 1.91878694242516 0.0204890192374137 no 176 0.0275056515175813 225 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1462 k081-0014 26.5 µM 1.90260179660919 0.021327547238956 no 177 0.0285462622763672 153 3270634
SGTC_2067 5224629 34.075 µM 1.89658113976781 0.0216467875847079 no 178 0.0289416208662832 269 2835000
SGTC_3218 9131285 49.47 µM 1.8877671684828 0.0221214169944507 no 179 0.0295286072902789 305 17156417
SGTC_778 3456-2434 196 µM 1.87786937472071 0.0226648498355947 no 180 0.0301995184257746 341 5539063
SGTC_1738 st035555 74 µM 1.87644775330968 0.0227438197803713 no 181 0.0302969112836345 293 5331140
SGTC_2452 5863136 48.41 µM 1.87618306304191 0.0227585486924481 no 182 0.0303150734754435 257 2184096
SGTC_1065 prochlorperazine maleate 2.48 µM 1.87398588405579 0.0228811231419206 no 183 0.0304661853749783 269 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_784 4579-0127 173 µM 1.8703810907375 0.0230834290817125 no 184 0.0307154579643262 248 1948547
SGTC_1052 3253-3998 198 µM 1.86420054303017 0.023433794775517 no 185 0.0311467735759683 307 5450317
SGTC_553 k007-0256 45.7 µM 1.85409287272247 0.0240164215048622 no 186 0.0318629371052363 288 6287000
SGTC_440 fluspirilene 35.1 µM 1.84757570749935 0.0243985011706129 no 187 0.0323318733184837 280 3396 An atypical antipsychotic.
SGTC_657 3534-0529 86.7 µM 1.84612465706778 0.0244842624813244 no 188 0.0324370537098532 266 1049549
SGTC_2771 fluoxetine 41.05 µM 1.84139986730662 0.0247652665081668 no 189 0.0327814911241647 242 3386 A selective serotonin reuptake inhibitor.
SGTC_3041 9091929 49.47 µM 1.84135379402798 0.0247680199516921 no 190 0.0327848646562554 290 25236887
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.82603116375838 0.0256980874172331 no 191 0.0339227838907337 276 3256 An antibiotic and ribosome inhibitor.
SGTC_1783 st039459 87.517 µM 1.81921572312186 0.026121074940956 no 192 0.0344392624888672 317 729761
SGTC_2912 7964298 10.93 µM 1.81451635847478 0.0264161109701112 no 193 0.0347991332881256 372 2975850
SGTC_2878 9043973 25.97 µM 1.80564250695366 0.0269808261376077 no 194 0.0354870992476165 245 6465167
SGTC_3246 9135460 32.98 µM 1.80513496501025 0.0270134274949196 no 195 0.0355267823951287 190 41446951
SGTC_2636 apigenin dimethyl ether 100 µM 1.80485551704794 0.0270313915350048 no 196 0.0355486470993655 338 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_926 2268-1401 59.4 µM 1.79880139962958 0.0274230288922255 no 197 0.0360250509335291 296 2931578
SGTC_2232 chlorophetanol 41.5365 µM 1.79662770545037 0.0275647933749065 no 198 0.0361973714974311 427 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1883 5-benzylidenerhodanine 20 µM 1.78959061348989 0.0280279365226847 no 199 0.036759874290065 382 1273210
SGTC_687 k029-0044 34.9 µM 1.78670924672134 0.0282194334337146 no 200 0.036992246903034 274 5829338
SGTC_3063 1327-0034 4 µM 1.78327722357337 0.0284489471817957 no 201 0.0372705935644362 280 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2332 7982454 138.89 µM 1.77964407345769 0.0286936012692667 no 202 0.0375671142531825 360 2981748
SGTC_2400 5203494 178.7 µM 1.7795023609602 0.0287031794446234 no 203 0.0375787190831801 274 6777674
SGTC_1797 st048695 56.8 µM 1.77727894842287 0.0288538056119297 no 204 0.0377611777611886 324 592262 YIL048W NEO1
SGTC_958 1222-0007 33 µM 1.77717026619985 0.0288611851548705 no 205 0.0377701149943767 315 7312461
SGTC_1844 rapamycin 4 nM 1.77380301404299 0.0290906006728781 no 206 0.0380478697043656 470 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1081 sertraline 6 µM 1.77368686383729 0.0290985411020649 no 207 0.0380574802417817 345 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2455 5377712 9.75 µM 1.77339999461325 0.029118160189255 no 208 0.0380812249518807 264 2243908
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.76816541656998 0.0294780889457985 no 209 0.0385166269452019 378 688664
SGTC_1323 1348-1351 11.2 µM 1.76301331980295 0.0298359452718807 no 210 0.0389491215924714 253 6989654
SGTC_2702 st077768 96.8 µM 1.75829133408611 0.0301670846533725 no 211 0.0393489757211683 289 6484119
SGTC_1220 1838-0075 193 µM 1.75602988176309 0.0303267495072414 no 212 0.0395416532039253 308 5529645
SGTC_1549 4'-methoxyflavonol 74.6 µM 1.75025081247281 0.0307379515513905 no 213 0.040037522184675 276 97141
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.74839499192724 0.0308709752095821 no 214 0.0401978272525756 324 688801
SGTC_1068 loratadine 26.9 µM 1.74770672580141 0.0309204305237077 no 215 0.0402574117946173 292 3957 A H1 histamine antagonist.
SGTC_3004 9076122 71.4286 µM 1.74641180890102 0.0310136544243678 no 216 0.040369709718109 317 44782551
SGTC_332 4112-0506 40.9 µM 1.73896750376496 0.0315541083610979 no 217 0.0410202395513561 288 2790355
SGTC_2745 rifampicin 24.3 µM 1.72664833773574 0.0324655617631784 no 218 0.0421154195677885 169 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2068 5226020 147 µM 1.72620923236763 0.0324984464382135 no 219 0.0421548888502639 350 1810509
SGTC_3173 9105693 49.47 µM 1.7254162728508 0.0325579009224586 no 220 0.0422262403854363 339 17096658
SGTC_911 3456-4043 236 µM 1.71905462222203 0.0330381385982288 no 221 0.0428022132038184 349 914281
SGTC_78 0336-0123 156.75 µM 1.71599117695045 0.0332714702008662 no 222 0.0430818286468125 285 6765896
SGTC_2484 5809818 12.04 µM 1.70198838307439 0.0343553553451373 no 223 0.0443787729949595 314 2870548
SGTC_1806 st050005 60.3 µM 1.69840036350278 0.034637707933505 no 224 0.0447161117743175 324 5194765
SGTC_2451 5856223 45.7 µM 1.69808317166513 0.0346627601873225 no 225 0.0447460326278856 310 2179896
SGTC_2856 9022925 19.48 µM 1.69118427095562 0.0352113367012986 no 226 0.0454008070708733 342 4944862
SGTC_1334 1486-0610 236 µM 1.69001557653513 0.0353049689311392 no 227 0.0455124873397157 342 3742339
SGTC_2713 st079149 53.4 µM 1.68723726655059 0.0355283786297897 no 228 0.0457788691266861 344 3103253
SGTC_3342 9147791 14.508 µM 1.68544860104367 0.0356728212837273 no 229 0.0459510267654157 322 1838168
SGTC_2990 9074105 71.4286 µM 1.68013739670707 0.0361045631937347 no 230 0.046465293142825 287 6502001
SGTC_854 0422-0053 192 µM 1.68004411296375 0.0361121841943857 no 231 0.0464743666135149 318 3596728
SGTC_1389 3405-0187 19 µM 1.67429450525369 0.0365844586295555 no 232 0.0470363669369047 330 799890
SGTC_1481 3346-2004 36 µM 1.673781223079 0.0366268643305841 no 233 0.0470868019603483 333 2770522
SGTC_1150 3909-7983 10.9 µM 1.66805985073959 0.0371022729669256 no 234 0.0476519231288306 382 23965914
SGTC_1944 st076371 56.9 µM 1.66426049028887 0.0374207525892302 no 235 0.0480301921759309 344 24208455
SGTC_501 nsc-95397 161 µM 1.66256057751214 0.0375639682111324 no 236 0.0482002139647425 301 262093
SGTC_1367 1812-0510 76.9 µM 1.66096104311184 0.0376991354547931 no 237 0.0483606355127001 336 1142582 YDR527W RBA50
SGTC_679 0422-0091 41.4 µM 1.65986094170937 0.0377923287858949 no 238 0.0484712152496555 381 627384 YHR062C RPP1
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.6583575570406 0.0379199895735241 no 239 0.0486226589850072 332 4213774
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.65585068358313 0.0381336445817659 no 240 0.0488760304143804 366 5377381
SGTC_640 3381-0960 37.1 µM 1.65454330560543 0.0382454583163049 no 241 0.0490085859788386 341 1745025
SGTC_2156 5649887 115 µM 1.64942917374603 0.0386854162988432 no 242 0.0495298710337829 386 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_3178 9107506 49.47 µM 1.64909906479739 0.0387139559639406 no 243 0.049563670606281 344 8897194
SGTC_1397 3532-0190 20.1 µM 1.64674290100614 0.0389181572701256 no 244 0.0498054510710269 267 5322280
SGTC_3008 9078912 71.4286 µM 1.64314673081559 0.0392315162486736 no 245 0.0501762890988189 317 16648731
SGTC_476 mead acid 10 µM 1.62849563449291 0.0405294552465444 no 246 0.0517099170707256 255 5312531 An omega 9 fatty acid.
SGTC_2129 girgensonine 121.053 µM 1.62417370416969 0.0409189243138421 no 247 0.052169370660099 400 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_633 0437-0093 97.7 µM 1.62375608862049 0.0409567178849006 no 248 0.0522139375746211 330 2831118
SGTC_2055 5235184 200 µM 1.61217779258099 0.0420158588386861 no 249 0.0534616281557016 375 2836034
SGTC_695 3505-6186 243 µM 1.61197524491825 0.042034582643972 no 250 0.0534836633595374 347 1819379
SGTC_1836 st055642 81 µM 1.60834450072826 0.0423713610856778 no 251 0.0538798747371907 382 8571
SGTC_2797 7859098 81.82 µM 1.60368404438055 0.0428068483576975 no 252 0.0543918573295826 389 972681
SGTC_2420 aureobasidin a 50 nM 1.60064891855292 0.0430923998829642 no 253 0.0547273504707412 428 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_308 4092-1169 104 µM 1.59907710562868 0.0432408832660721 no 254 0.0549017355162517 405 2268590 YDL196W YDL196W
SGTC_495 decylubiquinone 155 µM 1.59766243963046 0.0433748745837544 no 255 0.0550590610890034 366 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2210 7115885 190.385 µM 1.59594194035747 0.0435382847117278 no 256 0.0552508782906263 364 2927039
SGTC_1104 tacrolimus 29.8 µM 1.59254176743658 0.0438626886346238 no 257 0.0556315130328417 392 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2216 7189485 200 µM 1.5920642554271 0.0439084028656817 no 258 0.0556851337952608 304 731273
SGTC_3299 9121982 43.1275 µM 1.58811833949086 0.0442876344311731 no 259 0.0561297910067405 384 17594604 YPL160W CDC60
SGTC_2508 celastrol 40.54 µM 1.58742404426839 0.0443546336268177 no 260 0.0562083186009116 323 122724 Celastrol is a natural product and antioxidant.
SGTC_3338 9144300 39.5675 µM 1.58020816407801 0.0450558095976667 no 261 0.0570296013711086 388 4901274
SGTC_1249 0481-0015 10.2 µM 1.57497431015341 0.0455699501597536 no 262 0.0576311872405867 333 4227577
SGTC_3323 9138564 53.9225 µM 1.57168990892898 0.0458949906242909 no 263 0.0580112417944112 429 43912313 YNL103W MET4
SGTC_2571 chrysanthemic acid 100 µM 1.57148852348036 0.0459149811778354 no 264 0.0580346090536221 360 2743 An insecticide.
SGTC_3040 9091894 49.47 µM 1.57004422195326 0.0460585550583515 no 265 0.0582024118077293 309 25236966
SGTC_1935 st074532 41.6 µM 1.56386811796446 0.0466765768985109 no 266 0.0589242715734216 472 2829742
SGTC_2600 tangeritin 87.95 µM 1.56258804178152 0.0468054985342771 no 267 0.0590747613908432 369 68077 A bioactive flavone.
SGTC_748 act1.228 77.9 µM 1.56252055521769 0.0468123032969344 no 268 0.0590827036838309 450 4421505 YNR035C ARC35
SGTC_2997 9067075 71.4286 µM 1.5574581219107 0.0473250220275674 no 269 0.0596808779741084 435 27209819
SGTC_706 4262-0057 46.9 µM 1.55700280484791 0.047371355862448 no 270 0.0597349097404195 392 883298
SGTC_1763 st044482 94.5 µM 1.55615743962248 0.0474574780515933 no 271 0.0598353295429456 403 88505
SGTC_1923 st058458 19.1 µM 1.55201418875567 0.047881390313419 no 272 0.0603294143182128 447 3534982
SGTC_1303 1160-0052 261 µM 1.54982644083266 0.0481064472611934 no 273 0.0605915894660692 395 3562476
SGTC_2680 butyl paraben 22.24 µM 1.54120381236414 0.0490017247170994 no 274 0.0616335949750414 333 7184 An antifungal and steroid mimetic.
SGTC_1098 clofazimine 15.1 µM 1.53777128755695 0.0493618031315866 no 275 0.0620522731499824 447 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1926 methyl fluorone black 53.6 µM 1.53749530534623 0.0493908457035206 no 276 0.0620860319054063 380 72721 Reacts with homocysteine.
SGTC_1243 0416-0003 5.65 µM 1.52398363039838 0.0508294862405242 no 277 0.0637564002159599 423 2141977
SGTC_1338 1486-1223 76 µM 1.52397982839782 0.0508298956999141 no 278 0.0637568751063322 428 3444526
SGTC_1982 st072467 71.9 µM 1.52189884555648 0.0510544031437181 no 279 0.064017214248442 471 3163533
SGTC_2199 6590217 200 µM 1.52178476787493 0.0510667332290636 no 280 0.0640315096777689 332 703109
SGTC_2304 7443016 91.4 µM 1.5194296306028 0.0513218181301002 no 281 0.0643271941570082 357 939854
SGTC_889 0919-1524 82.7 µM 1.51384273805725 0.0519309890575494 no 282 0.0650328650815474 399 3905452
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.50977271537067 0.0523783736207197 no 283 0.0655507147088583 411 688662
SGTC_1847 st056231 15 µM 1.50899142819869 0.0524646032482674 no 284 0.0656504866666767 498 5393180
SGTC_2906 7926292 26.41 µM 1.50521213533739 0.0528833108703278 no 285 0.066134773097305 427 2966319
SGTC_3354 9151612 71.43 µM 1.50456394765045 0.0529553891101199 no 286 0.0662181105262204 437 27261949
SGTC_2190 6049624 200 µM 1.49580838407648 0.0539366581986172 no 287 0.0673517979540428 348 2265554
SGTC_516 3992-2719 87.3 µM 1.49529196377628 0.0539949819755549 no 288 0.0674191307406066 383 5350887 YDR037W KRS1
SGTC_1148 3909-7663 27.7 µM 1.48929938833485 0.0546754319051372 no 289 0.0682042743679441 431 4084526
SGTC_412 gemfibrozil 100 µM 1.48477700289752 0.0551934183387345 no 290 0.0688014528816523 358 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2522 biochanin a 4.94 µM 1.48138521715644 0.0555844455904641 no 291 0.0692519758596459 387 5280373 A possible chelator.
SGTC_877 0771-0151 33.1 µM 1.47639998985783 0.0561631403747077 no 292 0.0699182727200663 462 6166523
SGTC_3250 9135583 49.47 µM 1.47582993076995 0.0562296155081986 no 293 0.0699947767802051 390 7699353
SGTC_211 3455-0679 143.504 µM 1.47147934156942 0.0567389871639132 no 294 0.0705807651606448 464 748649
SGTC_1893 st059353 36.1 µM 1.47116111980889 0.0567763870994248 no 295 0.0706237745462167 457 3112488
SGTC_602 3130-1533 38.1 µM 1.46927426520596 0.0569985442085471 no 296 0.070879207023477 485 720941
SGTC_7 0192-1582 4.227 µM 1.46852019659361 0.0570875189696168 no 297 0.0709814871429414 537 252616
SGTC_1271 0832-2808 169 µM 1.46710483691895 0.0572548165644072 no 298 0.0711737692758711 446 3663794
SGTC_2909 7941780 10.49 µM 1.463937938683 0.057630545996356 no 299 0.071605453082331 443 1243215
SGTC_2648 atorvastatin 78.68 µM 1.46340728992624 0.0576936928654401 no 300 0.0716779825584665 402 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1502 4534-4282 27.7 µM 1.45937189534038 0.0581756839994824 no 301 0.0722313885164005 398 3278949
SGTC_527 4476-4215 268 µM 1.45805449891467 0.0583337181766238 no 302 0.0724127608691569 452 4418754
SGTC_2841 9004761 38.96 µM 1.45553632407799 0.0586367351852149 no 303 0.0727604208636208 406 2991039
SGTC_199 4063-0024 41.6 µM 1.44801530781159 0.0595491140635472 no 304 0.0738063847485112 428 306215
SGTC_3006 9075424 71.4286 µM 1.44756302725222 0.0596043331709428 no 305 0.0738696488109006 431 7465181
SGTC_1932 st074806 40.9 µM 1.44708223506046 0.0596630772668361 no 306 0.0739369464543884 487 17251235
SGTC_2775 cyproheptadine 69.59 µM 1.44438163154615 0.0599938855805291 no 307 0.0743158273656579 443 2913 A selective serotonin reuptake inhibitor.
SGTC_849 0386-0493 241 µM 1.44260773134146 0.0602119585556842 no 308 0.0745655021149744 430 726119
SGTC_1681 tripelennamine 100 µM 1.43856992127325 0.0607106570051587 no 309 0.0751362067936791 400 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_141 0443-0274 32.331 µM 1.43753993627128 0.0608383832372721 no 310 0.0752823168349057 586 1627241
SGTC_879 0831-1030 162 µM 1.43334086225284 0.0613612770146824 no 311 0.0758802248876388 535 1549252
SGTC_3122 9126309 49.47 µM 1.43249676300257 0.0614668118815672 no 312 0.0760008519213215 419 17591206
SGTC_2801 7907800 81.82 µM 1.42872842129339 0.0619396849860102 no 313 0.076541152823385 482 6620925
SGTC_1451 4152-0210 104 µM 1.42620079563253 0.0622584534538436 no 314 0.0769051950273698 474 659563
SGTC_3255 9139072 49.47 µM 1.42602168213923 0.0622810905957112 no 315 0.0769310417673752 453 17646060
SGTC_1364 1653-0028 37.6 µM 1.42458282344854 0.0624631728023665 no 316 0.077138914036905 480 5718652
SGTC_149 3970-0822 46.1 µM 1.42392576996625 0.0625464583913479 no 317 0.0772339805470476 621 3114250 YBL034C STU1
SGTC_3282 9108498 15.4605 µM 1.42180208329423 0.0628162409823541 no 318 0.0775418573264567 486 16459645
SGTC_1398 3558-0053 112 µM 1.42158045852519 0.0628444472602348 no 319 0.0775740405129073 383 4532369
SGTC_1841 st054148 70 µM 1.42135641254245 0.062872971716691 no 320 0.0776065856032581 425 675442
SGTC_249 wiskostatin 11.211 µM 1.42039501987403 0.0629954861301762 no 321 0.0777463559276053 458 2775510 A n-wasp and actin depolymerizer.
SGTC_3023 9089636 49.47 µM 1.41855178105066 0.0632308979666938 no 322 0.0780148660938827 467 17249241
SGTC_1454 4239-0054 42.6 µM 1.41235932289623 0.064026794983689 no 323 0.078922093610837 529 1340767
SGTC_1290 0986-0249 10.2 µM 1.41178193457375 0.0641014001078309 no 324 0.0790070896615354 421 53329
SGTC_822 1487-0950 154 µM 1.40693967307888 0.0647297379611337 no 325 0.0797226390579964 463 1958375
SGTC_2358 9037157 4 µM 1.40670981653037 0.0647596829202784 no 326 0.0797567268375714 477 2388925
SGTC_1047 2043-3044 82 µM 1.40601947331606 0.0648496832474886 no 327 0.0798591711763667 495 669592
SGTC_2053 5265679 138 µM 1.400287554751 0.0656007107575669 no 328 0.0807136130555394 511 764595
SGTC_3069 9117009 49.47 µM 1.39282291162719 0.0665888582809044 no 329 0.0818366741046967 359 41904981
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.39249811085209 0.0666321145879099 no 330 0.0818858066580306 523 5106787 A p450 inhibitor.
SGTC_3352 9151559 45.5865 µM 1.39177675466617 0.0667282611215239 no 331 0.081995005581303 471 17159339
SGTC_3142 9086498 49.47 µM 1.38627664754753 0.0674648808659408 no 332 0.0828312223709413 461 25236367
SGTC_1704 st028805 70.8 µM 1.38616201474996 0.0674803000212768 no 333 0.0828487187404956 471 2876101
SGTC_3111 9122088 49.47 µM 1.38328243992426 0.067868523180765 no 334 0.0832891400950189 368 16876704
SGTC_1761 st044296 37 µM 1.37863793425755 0.0684983253718917 no 335 0.0840032072309343 487 1826700
SGTC_3044 9093193 49.47 µM 1.37855946539702 0.0685090044693215 no 336 0.0840153107488161 515 25236277
SGTC_29 0299-0004 12.984 µM 1.37777452108086 0.0686159009375772 no 337 0.0841364574405494 388 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2996 9066192 71.4286 µM 1.37481385407412 0.069020252918041 no 338 0.0845945809458754 513 6472854
SGTC_905 2-aminofluorene 215 µM 1.37364957013262 0.069179766735538 no 339 0.0847752499502896 526 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.36984891970961 0.0697024558757384 no 340 0.085367033828127 491 390807
SGTC_1109 tnp00067 928.257 nM 1.36230335024472 0.0707491723727334 no 341 0.0865510853889349 510 676295
SGTC_1957 st077035 62.4 µM 1.36149155455935 0.070862499945198 no 342 0.0866792003308051 496 705593
SGTC_3059 1327-0034 3 µM 1.36105363852537 0.0709236913846208 no 343 0.0867483696307185 517 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.35812867588657 0.0713334474278315 no 344 0.0872114287338121 532 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2264 7948757 110.76 µM 1.35778971992622 0.0713810487924867 no 345 0.0872652089175725 484 2971411
SGTC_1069 diphenylcyclopropenone 8.49 µM 1.35665677148011 0.071540331637112 no 346 0.0874451469991313 574 65057 A dermal irritant. YDR527W RBA50
SGTC_572 0960-0087 17.7 µM 1.35603057207507 0.0716284868622338 no 347 0.087544720518686 571 6796365
SGTC_2019 4016004 108 µM 1.35498623269944 0.0717756924435239 no 348 0.0877109716988816 441 45595336
SGTC_1654 st012436 41.8 µM 1.35307182480356 0.0720461415378954 no 349 0.0880163428573454 458 4323132
SGTC_570 0987-0065 62.6 µM 1.35045192186714 0.0724175214513457 no 350 0.0884355328126703 388 3104428
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.34326142398187 0.0734443351294652 no 351 0.0895936692433342 313 4000243
SGTC_2202 7226349 200 µM 1.34005119596545 0.0739063399760247 no 352 0.0901143505869191 447 844334
SGTC_2458 5808907 16.39 µM 1.33829521054733 0.0741599931869423 no 353 0.0904001112461706 538 2731747
SGTC_1016 4226-1401 38 µM 1.33473515506687 0.0746762853963532 no 354 0.0909815216446463 532 2901613
SGTC_1232 0279-0259 161 µM 1.33440818836663 0.0747238404881436 no 355 0.0910350589671935 527 1560000
SGTC_851 0394-0702 453 µM 1.33229661902729 0.0750315106276156 no 356 0.0913813688564177 569 762646
SGTC_1408 3909-7976 48.8 µM 1.33183843116557 0.0750983991312184 no 357 0.0914566431587668 578 24152374
SGTC_2610 ononetin 44.17 µM 1.33068355112134 0.075267195907926 no 358 0.0916465788136313 553 259632
SGTC_2479 5617353 43.85 µM 1.32655495190293 0.0758729959560273 no 359 0.0923279729559555 526 2731746
SGTC_2643 anethole 100 µM 1.31975253225694 0.0768792216410641 no 360 0.0934588272740973 544 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_530 4358-1714 28 µM 1.31770897357985 0.077183481352276 no 361 0.0938005447195349 608 1564641
SGTC_2583 asiatic acid 100 µM 1.31594411693808 0.077446981414207 no 362 0.0940963999446061 506 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2973 9094665 17.96 µM 1.31592696927519 0.0774495449750067 no 363 0.0940992779002031 580 25237061 YIL048W NEO1
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.31454619056073 0.0776561817916842 no 364 0.0943312322998344 613 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2071 5230951 39.92 µM 1.31306061193365 0.0778789692788326 no 365 0.0945812624392372 570 1799272
SGTC_2426 5582046 32.21 µM 1.30586957496518 0.0789642475204386 no 366 0.0957984573723089 558 2251934
SGTC_2054 5233173 129 µM 1.30561402795429 0.0790030246434734 no 367 0.0958419237203763 602 6889
SGTC_2595 hexamethylquercetagetin 100 µM 1.30538738973961 0.0790374271644976 no 368 0.0958804850671583 531 386331
SGTC_1179 1021-1431 9.29 µM 1.30434995911427 0.0791950486717075 no 369 0.0960571443200593 603 2840958
SGTC_798 1287-0182 476 µM 1.30395829879662 0.0792546172356891 no 370 0.0961239005351389 595 1649755
SGTC_3217 9129673 49.47 µM 1.30191312809744 0.0795662233444386 no 371 0.0964730420714529 542 17248312
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.29696498177522 0.0803239660202019 no 372 0.0973216179823989 585 6708561
SGTC_3319 9138450 16.7555 µM 1.29481248261311 0.0806552895619536 no 373 0.0976924624099304 516 2029690
SGTC_3036 9090181 49.47 µM 1.2937912704882 0.0808128402303435 no 374 0.0978687644006176 524 25236586
SGTC_581 0958-0271 211 µM 1.2896395616605 0.0814557512082186 no 375 0.0985879165034155 657 4591145
SGTC_2445 5742597 35.57 µM 1.28879280452183 0.0815873477098007 no 376 0.0987350641123724 531 1774255
SGTC_2756 carbadox 75.1 µM 1.28842399176139 0.0816447158522735 no 377 0.0987992058162974 575 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1103 duloxetine 36.1 µM 1.28677608774531 0.0819014158442898 no 378 0.099086171912234 623 60835 A selective serotonin reuptake inhibitor.
SGTC_1312 1218-2183 165 µM 1.2848247477635 0.0822061691344634 no 379 0.0994267661325704 569 6744073
SGTC_1666 st014829 29 µM 1.28276815763073 0.0825282836514531 no 380 0.0997866565287314 583 3858230
SGTC_2041 5107442 45.335 µM 1.2827192537434 0.0825359547974303 no 381 0.0997952259709766 558 793005
SGTC_1198 1612-1005 86.7 µM 1.28216512848183 0.0826229133190926 no 382 0.0998923630584207 576 6998509
SGTC_1652 st011932 78 µM 1.28096230641382 0.0828119086845164 no 383 0.100103453045735 536 1551076
SGTC_184 1494-0393 24.714 µM 1.27424840493446 0.0838728205216413 no 384 0.10128769770906 585 3090647
SGTC_1662 st014054 52 µM 1.26870126911883 0.0847570376604175 no 385 0.102273814829627 521 2838777
SGTC_2581 avocatin a 64 µM 1.26175371753702 0.0858743190535457 no 386 0.103518710437491 616 6710728 A skin care supplement.
SGTC_1014 4130-3005 69.3 µM 1.25415577571352 0.0871087730702968 no 387 0.104892695323069 600 743608
SGTC_1041 0206-0046 107 µM 1.25120929981504 0.0875910431038951 no 388 0.10542906307332 580 50494
SGTC_2560 caryophyllene 100 µM 1.24998105457778 0.0877926657958843 no 389 0.10565323407187 624 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2844 9010103 25.97 µM 1.24873296885981 0.0879978998223406 no 390 0.105881379042428 586 2480525
SGTC_3347 9188721 44.724 µM 1.24779069888854 0.0881530826455335 no 391 0.106053857873706 544 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_166 k072-0058 166.424 µM 1.24349158551861 0.0888636947439098 no 392 0.106843369888178 594 5846229
SGTC_2070 5230947 200 µM 1.24334282526037 0.0888883598502938 no 393 0.106870764717892 605 2835538
SGTC_2120 5538279 151.968 µM 1.2431459183544 0.088921015720959 no 394 0.106907033749092 580 2058197
SGTC_2326 6164455 177.58 µM 1.24289434017364 0.0889627515005133 no 395 0.106953385809603 543 2888790
SGTC_2095 5432005 200 µM 1.24235545164518 0.0890521999472806 no 396 0.10705272219225 539 783734
SGTC_1676 st018489 23.4 µM 1.23985937810413 0.089467388739853 no 397 0.107513705573066 594 3696235
SGTC_1085 doxorubicin 7.67 µM 1.23840542937956 0.0897098964953315 no 398 0.107782884240236 634 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2739 tacrine 100.86 µM 1.23708308757824 0.0899308772385361 no 399 0.108028118917019 554 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2418 pentamidine 31.67 µM 1.23529114594424 0.0902309794865743 no 400 0.108361083879388 564 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2606 farnesol 9.78 µM 1.23506713352382 0.0902685478151595 no 401 0.108402760037313 600 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2363 9053361 176 µM 1.2344167731921 0.0903776832638891 no 402 0.108523820994376 613 6469797 YMR079W SEC14
SGTC_2623 humulene 100 µM 1.23359757988072 0.0905152895781042 no 403 0.108676447640072 511 6187145 An anti-inflammatory.
SGTC_3073 9114972 49.47 µM 1.22852522210428 0.0913707981782613 no 404 0.109624933580281 540 41905075
SGTC_2168 5727979 200 µM 1.22557725724557 0.0918707509558937 no 405 0.110178900298961 541 695210
SGTC_1950 st077106 7.18 µM 1.22552954598834 0.0918788590562318 no 406 0.110187882439914 617 13831864
SGTC_1897 st060201 15 µM 1.22369332936714 0.0921913104464373 no 407 0.110533968509437 568 611878
SGTC_335 4077-0256 27.6 µM 1.22289850492839 0.0923268017604771 no 408 0.110684016666237 678 3121989
SGTC_297 0986-0032 24 µM 1.21964414035659 0.0928831005659789 no 409 0.111299902851012 567 2847425
SGTC_3002 9075603 71.4286 µM 1.21963835419358 0.092884091850814 no 410 0.11130100005867 631 20105405
SGTC_343 4130-2827 29.8 µM 1.21946300098379 0.092914137054748 no 411 0.111334255281132 637 1118244
SGTC_3265 9137266 49.47 µM 1.21075228406531 0.09441569836101 no 412 0.112995178791195 535 17224265
SGTC_1691 st019933 84.6 µM 1.21005410904998 0.0945368205394369 no 413 0.113129065413119 581 6176082
SGTC_2285 7945142 200 µM 1.20838746756068 0.0948264191757392 no 414 0.113449129055695 583 2970608
SGTC_1175 0741-0056 27.6 µM 1.20808372683898 0.0948792680606249 no 415 0.113507529254134 686 765927
SGTC_2459 5811157 9.22 µM 1.20725676504276 0.0950232639333202 no 416 0.113666637739382 588 2870684 YBR192W RIM2
SGTC_1017 4239-0030 168 µM 1.20411233014026 0.0955722628532159 no 417 0.114273082418744 645 1149593
SGTC_2116 5511452 16.8835 µM 1.20343439408864 0.0956909315677079 no 418 0.114404132465436 627 870744
SGTC_813 k007-0158 173 µM 1.20148661811412 0.0960324814118496 no 419 0.114781247162602 688 6523916
SGTC_1129 3453-1384 223 µM 1.19925877156175 0.0964242407291353 no 420 0.115213670467542 671 1084452
SGTC_1289 0976-0073 69.1 µM 1.19837909717712 0.0965792514724481 no 421 0.115384733120973 662 3391136
SGTC_975 1335-0046 28.5 µM 1.1976981288592 0.0966993731162175 no 422 0.115517279020671 605 16486740
SGTC_3355 9151058 44.0485 µM 1.1958062910025 0.09703366588783 no 423 0.115886080186117 603 17015728
SGTC_235 0330-0087 5 mM 1.18949433122425 0.0981551417585897 no 424 0.117122600203969 648 46494818 YHR062C RPP1
SGTC_2143 5623677 140.463 µM 1.18667242208903 0.0986595839703005 no 425 0.117678428530632 590 5375313
SGTC_1698 5-fluorocytosine 1.055 µM 1.18618077790018 0.0987476636413861 no 426 0.117775457801429 629 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1669 st015249 58.4 µM 1.18256385067847 0.0993974175661254 no 427 0.118491023135625 624 722793
SGTC_3151 9099821 49.47 µM 1.18196691260604 0.0995049528019078 no 428 0.118609414896536 606 17174189
SGTC_1372 2752-0194 270 µM 1.17566995274943 0.100644499724834 no 429 0.119863395051084 589 823334
SGTC_2239 6685329 187.64 µM 1.17466260019192 0.100827677782327 no 430 0.120064863851437 634 805680
SGTC_1936 st074407 74.3 µM 1.16907551324887 0.101848054116778 no 431 0.121186604289005 679 809813
SGTC_260 nsc-65238 3.989 µM 1.16785139553628 0.102072616507443 no 432 0.121433356267461 618 3246252
SGTC_2511 berberine 10.47 µM 1.16668152266711 0.102287564227038 no 433 0.121669503707824 644 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2943 9068529 45.32 µM 1.16343837714957 0.102885167669881 no 434 0.122325843254414 679 3270634
SGTC_691 1548-0686 185 µM 1.16247161977295 0.103063798607919 no 435 0.122521973092099 671 46495133
SGTC_1977 st070720 65.3 µM 1.16188168062094 0.1031729142173 no 436 0.122641764694709 595 682188
SGTC_3333 9141820 12.094 µM 1.16168226519083 0.103209817216948 no 437 0.122682276079004 594 1939433
SGTC_2888 9058547 12.99 µM 1.16140996259575 0.103260223894191 no 438 0.122737609700663 555 16476514
SGTC_3014 9081533 49.47 µM 1.15377688573503 0.104680484484562 no 439 0.124295826432385 687 21367265
SGTC_1779 st039427 55 µM 1.15262342989694 0.104896328719677 no 440 0.124532491038513 749 1124498
SGTC_195 4234-0266 16.654 µM 1.15175631284571 0.105058802896989 no 441 0.124710612324831 713 2303354
SGTC_1335 1486-0900 202 µM 1.15059509540589 0.105276668679214 no 442 0.124949425842127 680 X1335
SGTC_2621 lithochol-11-enic acid 100 µM 1.14594658584887 0.106152088032443 no 443 0.125908626906822 704 6708711
SGTC_1747 st037496 66.6 µM 1.14573541337064 0.106191981080308 no 444 0.125952323096306 691 723305
SGTC_380 3970-0968 6 µM 1.14529400753324 0.106275402982408 no 445 0.126043693737254 634 2891601
SGTC_3229 9132204 49.47 µM 1.14352987010297 0.106609282356725 no 446 0.126409330103966 620 17682924
SGTC_2338 7999974 200 µM 1.14180444006761 0.106936567754072 no 447 0.126767658181816 733 315925
SGTC_2016 5121758 140 µM 1.13935699159086 0.1074020503767 no 448 0.127277143318583 713 2795203
SGTC_361 000s-0510 1.45 µM 1.13346959817454 0.108527757552539 no 449 0.12850855061046 682 660
SGTC_899 1083-0020 478 µM 1.13346137162752 0.108529336436725 no 450 0.128510277040698 700 767123
SGTC_2714 st079313 56.9 µM 1.13235815631724 0.108741221307192 no 451 0.128741944602078 659 2939799
SGTC_87 0100-0052 35.5 µM 1.12947937389789 0.109295524244639 no 452 0.129347832904212 885 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1636 st007707 68.9 µM 1.12908839050942 0.109370963483572 no 453 0.129430274119682 727 403051
SGTC_428 3448-4153 16.5 µM 1.12744577203784 0.109688311144539 no 454 0.12977702793795 592 3834874
SGTC_841 0251-0215 91.2 µM 1.12587689066404 0.109992029776224 no 455 0.130108816120276 731 3888614
SGTC_634 1611-4317 11.2 µM 1.12274021071252 0.110601065622928 no 456 0.130773922432391 748 2843522
SGTC_2461 5755302 26.15 µM 1.11951480899233 0.111229844895456 no 457 0.131460288366648 723 2788904
SGTC_3305 9127027 53.8275 µM 1.1195081734237 0.111231141105852 no 458 0.131461702975188 688 41905295
SGTC_475 α-linolenic acid 10 µM 1.11913341233851 0.111304365530674 no 459 0.13154161374752 715 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1707 st032323 6.317 µM 1.11908903968051 0.111313037771555 no 460 0.131551077604055 704 3132057 YMR211W DML1
SGTC_56 0957-0365 83.25 µM 1.11812845464217 0.111500894151203 no 461 0.131756067609829 704 6752360
SGTC_3021 9087658 49.47 µM 1.1120223734261 0.11270033299881 no 462 0.133064265391282 658 25237042
SGTC_136 0097-0015 404.482 µM 1.10715105779236 0.113663808480227 no 463 0.1341143118472 752 4861337
SGTC_298 1391-0729 10 µM 1.10654186109304 0.11378471056913 no 464 0.134246027852629 677 3237558
SGTC_1205 4161-2785 76 µM 1.10511694630672 0.114067859134943 no 465 0.134554459249583 625 3498106
SGTC_1286 0929-0070 131 µM 1.10312598365152 0.114464328643816 no 466 0.134986229209122 730 1420408
SGTC_2505 galangin 7.89 µM 1.09921015432238 0.115246965489962 no 467 0.135838205300159 617 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2747 doxorubicin 7.63 µM 1.09806003550039 0.115477554909811 no 468 0.13608913742455 518 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_140 0062-0056 502.533 µM 1.09721896985746 0.115646389097539 no 469 0.136272841273481 748 3758964
SGTC_526 4469-0568 170 µM 1.09456120989341 0.116181055925539 no 470 0.136854458712087 691 2901964
SGTC_3152 9099253 49.47 µM 1.09326356994524 0.11644274111517 no 471 0.137139046504605 799 25236131
SGTC_1508 1080-0625 72.9 µM 1.08967282272969 0.117169038201373 no 472 0.137928645926225 679 767111
SGTC_3309 9129340 25.759 µM 1.08831744194803 0.117444022406561 no 473 0.138227496589713 766 17158987
SGTC_2614 arthonioic acid 13.39 µM 1.08664117834726 0.117784740042536 no 474 0.138597709551164 657 6710684
SGTC_2796 7949634 45.45 µM 1.08560770564575 0.117995152134738 no 475 0.138826294586771 672 2971588
SGTC_512 prima-1 270 µM 1.08452829171872 0.118215201469287 no 476 0.139065314939745 740 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_948 3448-0295 75.3 µM 1.08223292473656 0.118684099229393 no 477 0.139574520990042 759 678569
SGTC_1661 st013063 9.66 µM 1.07836508844655 0.119477190885466 no 478 0.14043543026794 780 721395
SGTC_1777 st045864 34.765 µM 1.07828077414266 0.119494520897314 no 479 0.140454237149134 743 4691462
SGTC_601 0986-0029 62.9 µM 1.07735433280914 0.119685059000333 no 480 0.140660998835504 754 24747981
SGTC_789 1309-1135 70.6 µM 1.07596737421566 0.119970710489774 no 481 0.140970923964638 726 3092424
SGTC_1963 st076565 50.3 µM 1.07437594954842 0.12029906450478 no 482 0.141327108638503 712 4914280
SGTC_850 0388-0143 75.9 µM 1.0673772759524 0.121750593033379 no 483 0.142900752799383 700 67273
SGTC_1057 3448-5381 134 µM 1.06555030167023 0.12213152562622 no 484 0.143313487683275 748 5497911
SGTC_3168 9103419 49.47 µM 1.06507507038797 0.122230750555633 no 485 0.143420979799144 649 16649256
SGTC_3198 9112019 49.47 µM 1.0642434065641 0.122404532230993 no 486 0.143609224012095 717 45595555
SGTC_500 h-89 112 µM 1.05454890544867 0.124443060126245 no 487 0.145815841219691 803 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1518 st038567 90.8 µM 1.05155972079622 0.125076377324247 no 488 0.146500798006871 730 77966
SGTC_148 3253-0744 288.01 µM 1.04731190324938 0.125980227456886 no 489 0.147477873962565 733 6893655
SGTC_1155 4088-0394 48.2 µM 1.04446313302041 0.126588933928873 no 490 0.148135583781751 734 2326248
SGTC_2283 7944793 200 µM 1.043130506621 0.126874382919546 no 491 0.148443926715015 745 2970533
SGTC_522 1273-0010 11.6 µM 1.04293791912425 0.126915672249891 no 492 0.148488523058068 735 5705015
SGTC_409 arachidonic acid 100 µM 1.03714031263418 0.128163016863877 no 493 0.149835235047374 756 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.03382725091692 0.128879626809372 no 494 0.150608464779244 778 229346 A bile salt which induces apoptosis.
SGTC_1080 nisoldipine 24.4 µM 1.03327532041373 0.128999278031846 no 495 0.150737536661499 784 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2106 5357045 167.29 µM 1.03290547101131 0.129079499575446 no 496 0.15082406911137 788 668842
SGTC_2703 st077852 53.4 µM 1.03223048850823 0.129225994639687 no 497 0.150982077783879 728 6281836
SGTC_3186 9110464 49.47 µM 1.03073500557795 0.129550977723889 no 498 0.151332552163793 759 17018021
SGTC_519 k048-0011 62.8 µM 1.0299736985867 0.129716634484726 no 499 0.151511176175673 764 6836379
SGTC_1880 MG-132 525 µM 1.02967964001893 0.129780659481265 no 500 0.151580208091109 721 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2863 9028737 58.44 µM 1.02768482799542 0.130215565090008 no 501 0.152049053459071 755 6460917
SGTC_2601 securinine 100 µM 1.02581978590715 0.130623089667844 no 502 0.152488268977952 736 442872 A GABA receptor antagonist.
SGTC_92 0063-0024 660.874 µM 1.02571052523537 0.130646991192261 no 503 0.152514025835419 854 3594437
SGTC_1162 k048-0130 20.1 µM 1.02355694507139 0.131118718919055 no 504 0.153022295051238 775 6797406
SGTC_3144 9087057 49.47 µM 1.01957144314489 0.131994817718341 no 505 0.153965877107926 758 17249618
SGTC_1005 4092-0690 4.4 µM 1.01908344000695 0.132102368059514 no 506 0.154081677631517 725 1529343
SGTC_3272 9137413 49.47 µM 1.01762529929972 0.132424085638266 no 507 0.154428029796019 746 17614870
SGTC_2728 chlorpromazine 9.18 µM 1.01154930958969 0.133770474603195 no 508 0.155876796584731 686 2726 A thorazine and dopamine antagonist.
SGTC_337 1315-0038 354 µM 1.00680246993206 0.134828861142212 no 509 0.157014853738277 792 1626437
SGTC_42 0133-0086 60.653 µM 1.0054424303284 0.135133160489217 no 510 0.1573419286963 730 162923 Model of phenazepam hydroxylation.
SGTC_226 1,3-diallylurea 8.28947 mM 1.00404123162779 0.135447161063999 no 511 0.157679370060021 757 74537 YKL182W FAS1
SGTC_2785 7756463 72.73 µM 1.00287591116953 0.13570868323176 no 512 0.157960368274339 786 2201551
SGTC_903 1134-0042 114 µM 1.00100193467809 0.136129967480019 no 513 0.158412936525408 796 701009
SGTC_2266 7929956 200 µM 0.997278668720459 0.136969639757294 no 514 0.159314632406232 808 2967153
SGTC_2743 auranofin 4.32 µM 0.99534121949569 0.137407971166599 no 515 0.159785168310782 777 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_3297 9117502 71.43 µM 0.9932847026393 0.137874287474184 no 516 0.16028561511949 829 7453720
SGTC_2857 9024691 58.44 µM 0.991205953714676 0.138346740926595 no 517 0.160792511995008 763 16478292
SGTC_2444 5485484 36.41 µM 0.990203033006933 0.138575076703027 no 518 0.161037445189834 845 6790631
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.985981510249798 0.139539008282275 no 519 0.16207109308014 865 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2364 9055074 200 µM 0.984539422867487 0.139869333264109 no 520 0.162425178890103 767 6470630
SGTC_2433 5607874 27.82 µM 0.984378239155728 0.139906287050111 no 521 0.162464786713254 800 2252428
SGTC_3112 9123419 49.47 µM 0.983285232819015 0.140157050217019 no 522 0.1627335379842 851 17015854
SGTC_1849 st056239 19.2 µM 0.982338795107493 0.140374433364292 no 523 0.162966484037845 805 5393181
SGTC_751 0833-0568 350 µM 0.982030441128443 0.140445307264734 no 524 0.163042425784903 809 6954252
SGTC_1567 st069303 68.4 µM 0.981603733179244 0.140543424407445 no 525 0.163147553809541 820 5581319
SGTC_325 2810-4341 181 µM 0.981043804049574 0.140672244976658 no 526 0.163285570347526 836 774970
SGTC_2774 tamoxifen 10.92 µM 0.980437424496886 0.140811842556136 no 527 0.163435121950632 822 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1195 1502-0147 41.1 µM 0.980035896420802 0.140904331991646 no 528 0.163534199906194 848 817940
SGTC_1985 st071382 65.5 µM 0.976280900308264 0.141771266097915 no 529 0.164462641100019 835 6123237
SGTC_2314 7727897 200 µM 0.976106240166691 0.141811678463785 no 530 0.164505909672425 814 900724
SGTC_1468 k284-1086 134 µM 0.975687543436483 0.141908587083756 no 531 0.164609663490415 881 15996457
SGTC_3000 9075062 71.4286 µM 0.974783460271046 0.142117992768734 no 532 0.164833841557055 784 17057871
SGTC_2212 7123476 200 µM 0.973372190262723 0.142445292017654 no 533 0.165184177647031 754 1085715
SGTC_942 3253-1115 227 µM 0.972768283097676 0.142585504749326 no 534 0.165334239732126 832 46497897
SGTC_369 0957-0393 4.5 µM 0.968118292108066 0.143668246459733 no 535 0.166492647686108 771 6997992
SGTC_2664 lyso-paf C-16 73.48 µM 0.96810593107349 0.143671132078374 no 536 0.166495734038965 879 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_890 0929-0006 47.2 µM 0.966858588329927 0.143962518816178 no 537 0.166807365496463 814 1378169
SGTC_2646 retinol 96.75 µM 0.965209576921827 0.144348349169975 no 538 0.16721992554837 813 445354 A vitamin A analog and teratogen.
SGTC_579 4491-1009 110 µM 0.96165248260845 0.145182997851492 no 539 0.168112099423489 1053 1271041
SGTC_2873 9040596 71.43 µM 0.96137652339089 0.145247885332784 no 540 0.168181442027178 825 6463863
SGTC_2895 9054447 58.44 µM 0.961019371538532 0.145331892953277 no 541 0.168271213905509 807 2697450
SGTC_1242 0402-0103 60.1 µM 0.960037914136792 0.145562915163127 no 542 0.168518066762499 787 432868
SGTC_532 1548-0774 215 µM 0.956812528410484 0.146323867192274 no 543 0.169330943762223 891 5932993
SGTC_153 4077-0274 519.67 µM 0.955627005756511 0.146604232820971 no 544 0.169630356302211 809 3121976
SGTC_88 0180-0332 8.668 µM 0.953213981289972 0.1471760048246 no 545 0.170240831954398 869 3101745
SGTC_2135 5326629 150.42 µM 0.949963018706537 0.147948689086662 no 546 0.171065521906047 794 5020077
SGTC_2978 9011784 42.97 µM 0.949232918406438 0.148122591038388 no 547 0.171251081341182 962 2994934
SGTC_1426 4048-4480 71.7 µM 0.947890749968057 0.148442637690466 no 548 0.171592537231189 873 14224343
SGTC_2881 9058953 51.95 µM 0.946412124936543 0.148795758090013 no 549 0.171969211737812 923 17122249
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.945205232838824 0.149084399907238 no 550 0.172277054226526 820 688803
SGTC_672 1441-0018 53.7 µM 0.945065542183963 0.149117832631239 no 551 0.172312707871538 814 251141
SGTC_2964 9083345 53.42 µM 0.94380483348344 0.149419789615634 no 552 0.172634695089887 808 17741579
SGTC_2383 9036125 200 µM 0.943269124473882 0.149548222734745 no 553 0.17277163217275 834 79580
SGTC_557 1315-0110 16.2 µM 0.942268773051874 0.14978824834687 no 554 0.173027525701857 878 6833801
SGTC_86 0417-1630 471.922 µM 0.942055439551914 0.149839469088535 no 555 0.173082128406551 955 3634867
SGTC_871 0574-0004 149 µM 0.941762374372461 0.149909852215694 no 556 0.173157156326604 869 9551173
SGTC_1515 3460-0031 42.1 µM 0.941601098413727 0.149948593980165 no 557 0.173198453586336 805 2876596
SGTC_2339 9000433 200 µM 0.936087953551576 0.151276978809493 no 558 0.174613952432427 766 2988954
SGTC_577 r071-0003 38.6 µM 0.93574126658845 0.151360773351742 no 559 0.174703209056458 1003 4568517 YMR134W ERG29
SGTC_3090 9117696 49.47 µM 0.934074590752065 0.151764041187472 no 560 0.175132708926668 859 7923821
SGTC_2161 5662504 8.5105 µM 0.923127097072289 0.154430623892337 no 561 0.177970487512086 833 2859334
SGTC_2598 perillyl alcohol 100 µM 0.92037671684578 0.155105398863914 no 562 0.178687965720552 897 10819 An apoptosis inducer.
SGTC_1778 st046819 58.9 µM 0.920307013071235 0.155122525158205 no 563 0.178706172633659 952 671715
SGTC_886 0866-0150 153 µM 0.920280485280098 0.155129043393729 no 564 0.178713102108848 949 271463
SGTC_2138 5575593 77.673 µM 0.919696966792705 0.155272467479149 no 565 0.178865569077174 884 762213
SGTC_144 4161-2749 112.381 µM 0.913087694094383 0.156903080957889 no 566 0.180598210955219 805 797501 YMR168C CEP3
SGTC_125 0133-0007 11.75 µM 0.912872473672719 0.156956368012424 no 567 0.180654808062154 1016 26541
SGTC_937 3122-0005 46.7 µM 0.911036793873041 0.157411353127439 no 568 0.181137993723133 953 759535
SGTC_415 dibenzyl ketone 100 µM 0.910877826339851 0.157450795004803 no 569 0.181179875040606 908 7593
SGTC_2794 7785382 27.27 µM 0.910818512769763 0.157465513123583 no 570 0.181195503247105 973 2205081
SGTC_2556 citropten 84.59 µM 0.908011775924441 0.158163012861172 no 571 0.181936000023314 972 2775 A potential DNA crosslinker.
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.904602859576834 0.159012882550449 no 572 0.182837909932711 838 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2821 7996764 71.43 µM 0.898940588750115 0.160431131699314 no 573 0.184342153432498 945 2987135
SGTC_2295 7971645 200 µM 0.896357028092494 0.161080982860035 no 574 0.185031055102983 881 2978226 YKL099C UTP11
SGTC_1801 st050089 28.441 µM 0.894146850374886 0.161638277217376 no 575 0.185621662571884 974 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1436 4092-1007 8.32 µM 0.892514719470305 0.162050623342016 no 576 0.18605855335611 917 2881121
SGTC_2293 7624732 200 µM 0.891989429235333 0.162183479743704 no 577 0.18619929916938 883 894453
SGTC_1404 3909-7820 48.3 µM 0.887941582692269 0.163209639278943 no 578 0.187286087700755 931 23741373
SGTC_1105 epirubicin 18.1 µM 0.887207221424893 0.163396256537198 no 579 0.187483672607563 894 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_277 nystatin 15.5 µM 0.883724825051241 0.164283095857119 no 580 0.188422387934858 989 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1355 1499-0035 1.68 µM 0.879560559958902 0.165347671999682 no 581 0.189548706265332 904 1548538
SGTC_321 4534-3890 65.3 µM 0.876941802170584 0.166019426969788 no 582 0.190259124735247 963 699746
SGTC_2726 cimetidine 79.27 µM 0.873869675174059 0.166809723304812 no 583 0.191094615425029 956 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_507 nimesulide 162 µM 0.869166923864795 0.168024186501754 no 584 0.192377918003367 957 4495 A COX2 inhibitor.
SGTC_2437 5741531 144.16 µM 0.866835802573443 0.168628291636438 no 585 0.19301599113261 994 2262990
SGTC_2413 inermin 26.06 µM 0.865182468876006 0.169057594718719 no 586 0.193469323009817 974 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2150 5556613 200 µM 0.863127784049337 0.169592089548555 no 587 0.194033606702984 981 743190
SGTC_2145 5634607 200 µM 0.861406540771946 0.170040678206647 no 588 0.19450708744954 901 308662
SGTC_61 0978-8327 98.565 µM 0.861137968242017 0.170110741834453 no 589 0.194581029931887 1025 6150059 YHR072W ERG7
SGTC_33 0986-0033 35.816 µM 0.858831276225075 0.170713259788366 no 590 0.195216804713526 927 2848082
SGTC_1796 st049173 110.4 µM 0.853361412214813 0.17214746443156 no 591 0.19672945673152 924 94134
SGTC_2843 9000894 45.46 µM 0.853272701391341 0.172170787701227 no 592 0.196754047432738 852 2242070
SGTC_2457 5731572 11.68 µM 0.853269881322812 0.172171529168276 no 593 0.1967548291882 993 2865357
SGTC_1721 st082152 9.2685 µM 0.853153331480075 0.172202174840082 no 594 0.196787139791767 939 5296051
SGTC_2835 9006588 71.43 µM 0.851068579154354 0.172750928528033 no 595 0.197365629187396 888 2345538
SGTC_3271 9137798 49.47 µM 0.850179686059972 0.172985243756465 no 596 0.197612596928357 892 6498326
SGTC_630 4356-0227 183 µM 0.848057162914176 0.173545566610983 no 597 0.198203068320789 948 779312
SGTC_3054 9094397 49.47 µM 0.84694610417117 0.173839333967346 no 598 0.198512581478838 1024 2598354
SGTC_762 1165-0429 115 µM 0.846850175586424 0.173864712604212 no 599 0.198539318448595 972 5967793
SGTC_949 1165-0505 146 µM 0.846321920501129 0.174004508716137 no 600 0.198686591267594 997 6244267
SGTC_2463 5473429 200 µM 0.846273462152693 0.174017336190445 no 601 0.198700104321975 947 5399405
SGTC_605 1315-0399 119 µM 0.84404962914453 0.174606656794693 no 602 0.199320836649914 1013 24020461
SGTC_1802 st050112 57.9 µM 0.843779438125297 0.174678344247114 no 603 0.199396333790565 1020 4662563
SGTC_1394 3474-0001 65.7 µM 0.840854599822095 0.175455562051244 no 604 0.200214697491701 873 5017666 YIL048W NEO1
SGTC_3326 9140064 16.379 µM 0.840699589131503 0.175496814144792 no 605 0.200258125409054 1007 1868434
SGTC_410 α-linolenic acid 100 µM 0.838860072983225 0.175986823139915 no 606 0.200773917725028 1000 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2439 5492030 7.2 µM 0.837713837697749 0.17629259413002 no 607 0.201095719943077 969 5722370
SGTC_3300 9124615 50.48 µM 0.835661427964164 0.176840936532535 no 608 0.201672700274503 981 24824903
SGTC_974 1326-0144 138 µM 0.831813012845036 0.177872020010832 no 609 0.202757248814774 1013 5411856
SGTC_754 3474-0146 171 µM 0.830911201794311 0.178114184282053 no 610 0.203011897527838 912 24762078
SGTC_170 4197-0004 226 µM 0.823148250199609 0.180207365242376 no 611 0.205211846600811 930 218692
SGTC_1000 4048-0884 8.67 µM 0.822715514811702 0.180324499362624 no 612 0.20533489520711 955 13040088
SGTC_611 3453-1652 23.7 µM 0.822180309272432 0.180469436480158 no 613 0.205487141877591 1040 1560575
SGTC_1947 st076332 61.6 µM 0.821995190382916 0.18051958487595 no 614 0.205539817121853 1022 24208416
SGTC_319 1348-1596 45.5 µM 0.821618729551225 0.180621594440149 no 615 0.205646963094413 1027 5380505
SGTC_1070 indatraline 8.81 µM 0.821141210228472 0.180751039812197 no 616 0.205782919401383 986 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1483 3453-0561 55.9 µM 0.819115287143772 0.181300871205157 no 617 0.206360320378 1009 4546991
SGTC_684 1140-0066 328 µM 0.819085846441875 0.181308869064507 no 618 0.206368718236499 1055 6813534
SGTC_1758 st042942 75.2445 µM 0.817673583053877 0.181692783916878 no 619 0.206771799301941 1019 669317
SGTC_659 k018-0002 107 µM 0.817542103857139 0.181728551565868 no 620 0.206809349130522 1022 6797879 YHR007C ERG11
SGTC_2238 6671620 73.2395 µM 0.817450020557356 0.181753604563422 no 621 0.206835650083163 1053 729941
SGTC_1719 st032227 49.2 µM 0.817416182581467 0.181762811365498 no 622 0.206845315427583 1040 3125804
SGTC_3223 9129970 49.47 µM 0.816545374372212 0.181999845484091 no 623 0.207094141566838 1048 17248386
SGTC_2885 9057732 51.95 µM 0.815223368946744 0.18236006480529 no 624 0.207472231812733 1044 6471414
SGTC_3264 9137442 49.47 µM 0.814860796371955 0.182458936170322 no 625 0.207575997912679 991 17015726
SGTC_707 0865-0008 204 µM 0.813904618724191 0.182719840637668 no 626 0.207849797273013 1064 723043
SGTC_665 3914-0008 307 µM 0.813546529273092 0.182817609531489 no 627 0.207952390265258 1022 1069549
SGTC_2113 5491891 107.031 µM 0.811782457933289 0.183299729137401 no 628 0.208458234765861 1051 789979
SGTC_2114 5491910 81.25 µM 0.810605514281987 0.1836218276151 no 629 0.208796124575982 1014 2849228
SGTC_1891 st059073 26.2 µM 0.809904138812 0.183813943220379 no 630 0.208997636464946 1100 688754
SGTC_3356 9151811 4.48 µM 0.808326628265439 0.184246500567702 no 631 0.209451288680326 1005 1859254 YPR165W RHO1
SGTC_2194 5927483 104.545 µM 0.808064409812344 0.184318462875357 no 632 0.209526752204357 1071 760979
SGTC_2110 5483698 200 µM 0.804868968442301 0.185196813135989 no 633 0.210447648618607 1033 2848765 YHR062C RPP1
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.804772772462842 0.185223295348855 no 634 0.210475408190482 982 689007
SGTC_2394 5221648 200 µM 0.80457997975072 0.185276377178853 no 635 0.210531049450482 1108 788586
SGTC_2371 9071574 200 µM 0.80302296214729 0.185705418677841 no 636 0.210980731378609 1028 45596039
SGTC_1868 st057644 42.7 µM 0.799785639126765 0.186599445098079 no 637 0.211917502442043 1087 688665
SGTC_1613 st002381 52.1 µM 0.799662163268365 0.186633597148569 no 638 0.211953280255516 1080 551167
SGTC_586 0957-0265 8.15 µM 0.79634776063868 0.187551769791064 no 639 0.21291496628535 964 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_832 4083-0019 164 µM 0.796141789247757 0.187608921002205 no 640 0.212974813558853 1174 1990758
SGTC_1870 st057514 26.5 µM 0.794353705302966 0.188105515566094 no 641 0.213494773530845 1047 5393161
SGTC_1905 st060207 84.5 µM 0.793849772508501 0.188245616413327 no 642 0.213641446526848 1026 1948547
SGTC_1671 st016596 74.5 µM 0.793521738162731 0.188336849449573 no 643 0.213736954644135 1111 2829167
SGTC_2181 6316240 54.2555 µM 0.793473245696702 0.188350338506302 no 644 0.213751075470831 1014 12779990
SGTC_1901 st060216 58.6 µM 0.790312362274189 0.189230880534008 no 645 0.21467268445344 1080 688792
SGTC_661 1304-0007 33.6 µM 0.789678700970701 0.189407707016503 no 646 0.214857716601 1016 3117130
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.787559982489226 0.189999684548269 no 647 0.2154770649393 1093 5393153
SGTC_1380 2291-0730 164 µM 0.786754920527297 0.190224919582962 no 648 0.215712673615149 1023 2999191
SGTC_2528 xanthyletin 44.79 µM 0.785650759438103 0.19053410128809 no 649 0.216036059119966 1045 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_583 1488-1091 88.9 µM 0.784377775700115 0.19089093852459 no 650 0.216409237510701 1191 4303273
SGTC_2474 5321570 43.32 µM 0.780511916260251 0.191977109992158 no 651 0.217544808136861 1062 2841384
SGTC_2932 9016711 44.54 µM 0.779636670347999 0.192223547651327 no 652 0.217802382480658 1090 7117328
SGTC_1059 3448-6867 171 µM 0.778208778387643 0.192626005626358 no 653 0.218222971270501 1089 3934407
SGTC_1137 ixabepilone 100 µM 0.777947588059535 0.192699679009175 no 654 0.218299956070835 1050 154225 A novel microtubule stabilizer.
SGTC_2487 5918373 44.05 µM 0.776914280888187 0.192991310460821 no 655 0.218604672560944 1123 2876279
SGTC_1165 k072-0275 30.3 µM 0.776145395304432 0.193208488702649 no 656 0.218831571413556 1078 6153523 YGL055W OLE1
SGTC_1266 0828-0227 32.9 µM 0.775770897240882 0.193314322853088 no 657 0.218942135196348 1038 3913820
SGTC_2362 9071156 126 µM 0.774161867057797 0.193769441465541 no 658 0.21941753772918 1057 653133
SGTC_613 3914-0030 117 µM 0.773823816102633 0.193865143077064 no 659 0.219517493284912 877 1145395
SGTC_775 4577-0580 57.3 µM 0.773532739908989 0.193947569296881 no 660 0.219603580205744 1084 2006902
SGTC_463 ikarugamyin 104 µM 0.773402815761159 0.193984367780967 no 661 0.219642012037446 1101 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2026 5148700 152 µM 0.773335625179574 0.19400339987328 no 662 0.21966188866554 1087 79838
SGTC_385 1494-0393 12.4 µM 0.772616364988577 0.194207205448292 no 663 0.219874728234572 1071 3090647
SGTC_52 0329-0193 875 nM 0.771747942000218 0.194453450657363 no 664 0.220131864902343 1070 3739292
SGTC_1812 st052057 4.327 µM 0.771735964655551 0.194456848215 no 665 0.22013541255289 1135 3645418
SGTC_969 1313-0238 134 µM 0.769943557436945 0.194965699279945 no 666 0.220666687274586 1101 5212874
SGTC_2093 5331342 194.4 µM 0.76985213487894 0.194991675145734 no 667 0.220693804858576 1097 33839
SGTC_994 3910-0338 138 µM 0.76979956057979 0.195006614019521 no 668 0.220709400210868 1112 3479481
SGTC_1723 st034307 2.5525 µM 0.768544071322839 0.195363565266306 no 669 0.221082009139347 1100 867466
SGTC_1190 1486-1332 13 µM 0.768011122134428 0.19551520929591 no 670 0.22124028861717 1081 4150046
SGTC_1350 1495-0454 146 µM 0.767446576319202 0.195675921692005 no 671 0.221408022586662 1114 1069057
SGTC_796 1234-0020 70.7 µM 0.765858146229339 0.196128538997255 no 672 0.221880355916921 1087 46495034
SGTC_372 0155-0182 15.9 µM 0.765318439235696 0.196282470920209 no 673 0.222040973315856 1114 771486
SGTC_644 1498-1197 63.3 µM 0.76459879246528 0.19648783807122 no 674 0.222255244217684 1121 6741615
SGTC_1493 4348-0038 111 µM 0.764191454595082 0.196604138644784 no 675 0.222376579118834 1144 800424
SGTC_1692 fluoroquinolonic acid 71 µM 0.763941824059341 0.196675432207191 no 676 0.222450955952565 1084 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_773 4358-1457 44.6 µM 0.762316877854977 0.197139893489125 no 677 0.222935451483354 1135 1186886
SGTC_882 0843-0131 351 µM 0.761442837437097 0.197389996307161 no 678 0.223196304635622 1141 5425421
SGTC_2195 6536160 144.242 µM 0.761206937248895 0.197457530977365 no 679 0.223266737674689 1027 3834386
SGTC_1154 4088-0362 150 µM 0.76039495125724 0.197690097126689 no 680 0.223509270122102 1145 6618304
SGTC_767 0929-0023 86 µM 0.756362161142513 0.198847605367942 no 681 0.224716044062625 1194 1204563
SGTC_1173 0443-0020 122 µM 0.753475469536531 0.199678658958631 no 682 0.225582123350598 1108 5331295
SGTC_2165 5727197 32.143 µM 0.752709899845834 0.199899409970836 no 683 0.225812129814111 1174 1361712
SGTC_150 3970-0969 77.2 µM 0.75266842669309 0.199911372889006 no 684 0.225824593724189 1104 6615640
SGTC_1965 Pectolinarigenin 58.4 µM 0.750791535840355 0.200453211981945 no 685 0.226389062069074 1143 5320438 An anti-inflammatory.
SGTC_1351 1496-0003 46.5 µM 0.750738070697117 0.200468659729335 no 686 0.226405153187757 1131 3891978
SGTC_614 0462-0418 107 µM 0.750290244623035 0.200598078723015 no 687 0.226539958370078 1010 5188303
SGTC_2859 9028643 45.46 µM 0.749813557306927 0.200735893544659 no 688 0.226683501175987 1084 17151580
SGTC_1472 k841-0093 193 µM 0.74918972060554 0.20091633647838 no 689 0.226871431963575 1185 X1472
SGTC_2769 toremifene 3.73 µM 0.746708132956583 0.201635091424369 no 690 0.227619879695184 1114 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_593 1203-0218 61.7 µM 0.746608367733332 0.20166401910593 no 691 0.227649997961841 1162 3666956
SGTC_2256 7954252 200 µM 0.746017302832228 0.201835453832719 no 692 0.22782848140891 1059 2972920
SGTC_2684 capsaicin 100 µM 0.745805611164237 0.201896874911198 no 693 0.227892424937935 1107 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_840 0245-0196 390 µM 0.74293789393493 0.202730028039898 no 694 0.228759641095839 1165 3827528
SGTC_621 3584-0052 32.1 µM 0.741340218382459 0.203195087845077 no 695 0.229243590953702 1153 2273927
SGTC_1226 3909-7979 35.4 µM 0.739858618780174 0.203626928220974 no 696 0.229692892955552 1140 6615510
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.737941096495741 0.204186638316696 no 697 0.230275122078447 1157 94937 An inhibitor of serotonin biosynthesis.
SGTC_108 0509-0257 621.132 µM 0.737815518933944 0.204223325386267 no 698 0.230313280743305 1121 536624
SGTC_3193 9111931 49.47 µM 0.735090000628217 0.205020543294654 no 699 0.231142341867119 1168 17087244
SGTC_1166 k206-0078 225 µM 0.734940396517092 0.205064356196592 no 700 0.23118789732058 1163 5404595
SGTC_1147 3809-1045 12.3 µM 0.734697785265836 0.205135418899911 no 701 0.231261784718954 1107 325925
SGTC_3241 9133421 49.47 µM 0.733506305485001 0.20548462485843 no 702 0.231624841723735 1151 17018221
SGTC_2687 chenodiol 100 µM 0.733471034243263 0.205494967739536 no 703 0.231635594098114 1111 5702181 A cholesterol synthesis inhibitor.
SGTC_900 1112-0045 141 µM 0.731774671770494 0.205992771145911 no 704 0.232153055431649 1046 56211 YIL048W NEO1
SGTC_1955 wogonin 32.4 µM 0.730518018153518 0.206362001209794 no 705 0.23253680169231 1135 5281703 A flavanone.
SGTC_3099 9120367 49.47 µM 0.7296453085769 0.206618651406603 no 706 0.232803509755001 1179 24824940
SGTC_678 1218-2179 85.9 µM 0.729379758653006 0.206696782969717 no 707 0.232884697966443 1130 6820081 YOR116C RPO31
SGTC_2957 9076800 11.52 µM 0.728559735892588 0.206938164987517 no 708 0.233135507821865 1093 16459615
SGTC_1225 1216-0074 20.6 µM 0.727962717265898 0.207114008369795 no 709 0.233318204552068 1132 4241466
SGTC_872 0588-0139 234 µM 0.727781522212322 0.207167394286345 no 710 0.233373668690077 1175 2047100
SGTC_1270 0831-1170 17.3 µM 0.725612991092149 0.207806944981171 no 711 0.234038027405121 1156 6764716
SGTC_147 4466-0538 29.23 µM 0.72560052926803 0.207810623632021 no 712 0.234041848277554 1255 6742687 YHR072W ERG7
SGTC_3095 9117207 49.47 µM 0.724296866810041 0.20819566888283 no 713 0.234441750064189 1109 17015229
SGTC_2429 5902844 64.44 µM 0.722200601407187 0.208815696557691 no 714 0.235085576818394 1172 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.722196929324431 0.208816783630081 no 715 0.23508670548275 1155 4330530
SGTC_2154 5570129 200 µM 0.721317319639112 0.209077276703215 no 716 0.235357151644911 1182 673366
SGTC_1400 3771-8998 51.5 µM 0.721179809961121 0.209118016961871 no 717 0.235399446101194 1115 670767
SGTC_433 pimozide 108 µM 0.720979247594131 0.209177446342825 no 718 0.23546114147062 1122 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2809 7964133 12.99 µM 0.720118135780346 0.209432718556345 no 719 0.235726131077107 1144 1253665
SGTC_1559 coumarin 343 70.1 µM 0.718020025082383 0.210055459645848 no 720 0.236372469834204 1161 108770 A hepatotoxic, DNA x-linker.
SGTC_1001 4048-4355 44.4 µM 0.71723688225587 0.21028818312712 no 721 0.236613972676977 1169 21824233
SGTC_529 4076-0302 30.3 µM 0.714964411712971 0.210964340783727 no 722 0.237315517053631 1109 5816522
SGTC_268 camptothecin 39.6153 µM 0.714133515562161 0.211211885975235 no 723 0.237572311555162 1168 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_182 3448-4371 550.524 µM 0.713046720779622 0.211535926666196 no 724 0.237908423438632 1189 3491403
SGTC_1805 st050013 60.3 µM 0.712810835933764 0.211606296941733 no 725 0.237981409719401 1117 4037144
SGTC_2029 5175081 200 µM 0.712620125621925 0.211663200555219 no 726 0.238040427299809 1185 1380876
SGTC_2148 5546263 113.568 µM 0.712544364186882 0.211685808527458 no 727 0.238063874805672 1140 792097
SGTC_2866 9034245 58.44 µM 0.712366475604487 0.211738897819878 no 728 0.238118934751519 1163 6462273
SGTC_2638 epoxomicin 18 µM 0.712014277059426 0.211844031378887 no 729 0.238227967574289 1157 9915668 A protesome inhibitor.
SGTC_3132 9126706 49.47 µM 0.710696069754538 0.212237795820507 no 730 0.238636297843304 1185 850858
SGTC_745 0469-0705 296 µM 0.710297030391346 0.212357077999186 no 731 0.238759980474189 1249 3486736
SGTC_1561 5-methoxyflavone 52.9 µM 0.709623182812997 0.212558595675308 no 732 0.238968919762117 1143 94525
SGTC_2005 4024620 188 µM 0.708622921250033 0.21285793504219 no 733 0.239279254185884 1187 236743
SGTC_2911 7942208 15.64 µM 0.708244852465568 0.212971140361924 no 734 0.239396608575332 1163 1243384
SGTC_837 0091-0265 12.5 µM 0.707209078033536 0.213281462709513 no 735 0.239718278964526 1143 759367
SGTC_3087 9117406 49.47 µM 0.707176798220955 0.213291138110765 no 736 0.239728307580244 1171 42546093
SGTC_2060 5238662 140 µM 0.707127328664143 0.213305966382817 no 737 0.239743677109241 1139 790130
SGTC_2679 rapamycin 1 nM 0.706856885441635 0.213387041118471 no 738 0.239827709701234 1193 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1028 k015-0029 4.8 µM 0.704421938829102 0.214117809367533 no 739 0.240585023701494 1196 4588309
SGTC_1687 st020778 55.3625 µM 0.702403763758392 0.214724599753139 no 740 0.241213699382402 1199 4259299
SGTC_3262 9137218 49.47 µM 0.701384915182792 0.215031308896217 no 741 0.241531416695263 1067 17650664
SGTC_1281 0884-0031 11.8 µM 0.697986265317367 0.216056259462254 no 742 0.242592891761684 1221 1548255
SGTC_551 k048-0028 34.9 µM 0.696707615157139 0.216442600806073 no 743 0.242992896059833 1197 6836383
SGTC_945 3381-0768 11.3 µM 0.696114281348771 0.216622011029259 no 744 0.2431786317254 1207 1126236 YIL048W NEO1
SGTC_1409 3909-8004 61.9 µM 0.695454037540345 0.216821754352658 no 745 0.243385402918107 1209 2119279
SGTC_123 0083-0120 66.675 µM 0.695372248913586 0.216846505247275 no 746 0.243411023600813 1149 16001701
SGTC_1197 1601-0112 267 µM 0.69533194882474 0.216858701470912 no 747 0.243423648334359 1201 7350313
SGTC_2390 9097792 176.6 µM 0.693937783097103 0.217280869134519 no 748 0.243860613769872 1174 4497149
SGTC_3331 9141060 1.957 µM 0.693020132633333 0.217559001930405 no 749 0.244148458578444 1195 4906567 YPR165W RHO1
SGTC_116 0155-0182 31.788 µM 0.691739951808322 0.217947357966347 no 750 0.244550326301075 1184 771486
SGTC_2000 st075254 36.4 µM 0.690761899317883 0.218244329425608 no 751 0.244857591392426 1177 17234175
SGTC_39 0986-0283 58.349 µM 0.690318231158339 0.218379119664594 no 752 0.244997042710536 1230 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2987 9018338 71.43 µM 0.689590984165048 0.218600167303381 no 753 0.245225719347032 1259 5055682
SGTC_3322 9139058 2.11 µM 0.689280037972795 0.218694719087939 no 754 0.24532352874681 1240 4908926 YPR165W RHO1
SGTC_600 1495-0418 41.6 µM 0.687847490841968 0.219130628552779 no 755 0.24577441303625 1216 5377768
SGTC_8 0354-0001 70 µM 0.686442631479823 0.219558597679377 no 756 0.246217014499874 1243 4993152
SGTC_1757 st041620 31.8375 µM 0.682939988851374 0.220627712773523 no 757 0.247322381957407 1227 5289815
SGTC_1167 k781-0610 148 µM 0.682698014671422 0.220701680760394 no 758 0.247398842253208 1239 4525169
SGTC_3169 9102970 49.47 µM 0.67814027122085 0.222097567551237 no 759 0.248841379500831 1278 17027839
SGTC_2942 9052777 62.25 µM 0.677742620909223 0.222219593310703 no 760 0.248967448852571 1309 6469503
SGTC_2011 4012611 177 µM 0.67759053874515 0.22226627242057 no 761 0.249015673314319 1241 2049887
SGTC_3106 9121286 49.47 µM 0.67653999435895 0.222588872442325 no 762 0.249348931168144 1253 15943471
SGTC_197 4544-0043 41.561 µM 0.67583988330316 0.222804009925199 no 763 0.249571154752683 1227 896523
SGTC_3308 9128332 17.569 µM 0.675725338594337 0.222839219702115 no 764 0.249607522619853 1238 17332805 YDL196W YDL196W
SGTC_1810 st050138 53 µM 0.675229851484043 0.222991563473804 no 765 0.249764871862517 1223 3444541
SGTC_2100 5377183 190 µM 0.674526553522889 0.223207903137024 no 766 0.249988304910103 1250 2844202
SGTC_2952 9073731 13.78 µM 0.674490759476595 0.223218916845033 no 767 0.249999679274407 1239 16457353
SGTC_980 1473-0395 201 µM 0.674310455726204 0.223274400407985 no 768 0.250056979027066 1182 768876
SGTC_1862 st057513 3.81 µM 0.671965425746191 0.22399673399164 no 769 0.250802853607487 1218 5393163
SGTC_1406 3909-7906 11.9 µM 0.671612284588601 0.22410562606482 no 770 0.250915277804234 1248 X1406
SGTC_1770 st043884 66.3 µM 0.671585866311472 0.224113773423776 no 771 0.250923689262821 1229 670149
SGTC_981 1488-1094 54.9 µM 0.670399838185638 0.224479716075451 no 772 0.251301468888528 1216 3449522
SGTC_2869 9037858 32.47 µM 0.670050616683452 0.224587531089864 no 773 0.251412761952039 1206 27187042
SGTC_1981 st071826 47 µM 0.669279734295018 0.224825629266132 no 774 0.251658525908141 1202 11838600
SGTC_2282 7944268 200 µM 0.668869767816208 0.224952311614644 no 775 0.251789278424591 1280 2970414
SGTC_2891 9063876 19.48 µM 0.667284791903155 0.225442460028245 no 776 0.252295119364717 1211 6472478
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.661531903251508 0.227226592029669 no 777 0.254135630958807 1292 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_66 0109-0187 42.4 µM 0.661257090163628 0.227312017946616 no 778 0.254223727327231 1252 759417
SGTC_2989 9073649 71.4286 µM 0.65873905237323 0.228095594467715 no 779 0.255031675418712 1249 21367202
SGTC_2062 5245942 200 µM 0.658659643468158 0.228120330038649 no 780 0.255057176722191 1311 1376160
SGTC_1407 3909-7909 12.3 µM 0.658345396208389 0.228218231654974 no 781 0.255158106883722 1262 4411780
SGTC_2611 pyromycin 23.93 µM 0.658137874125684 0.228282896708998 no 782 0.255224770425092 1236 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2022 5136654 200 µM 0.657996259326203 0.228327030592379 no 783 0.255270267408547 1247 1713771
SGTC_1460 k062-0059 9.15 µM 0.657097996890459 0.22860708339022 no 784 0.255558953412281 1226 1373085
SGTC_1417 3966-0327 90.4 µM 0.656104295000523 0.228917116133126 no 785 0.255878510572524 1296 651118
SGTC_398 bronopol 33.3 µM 0.655499213311352 0.229106015775032 no 786 0.256073196369226 1198 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1262 0737-0114 49.6 µM 0.654194449623034 0.229513645596994 no 787 0.256493268510536 1293 765919
SGTC_377 3970-0964 33.1 µM 0.651124070781137 0.23047448440752 no 788 0.257483199685612 1265 16481235
SGTC_3222 9128301 49.47 µM 0.650572124286094 0.23064744765951 no 789 0.257661364839108 1283 4911358
SGTC_2017 5132927 60.65 µM 0.64927245600717 0.231055010490792 no 790 0.258081142954653 1234 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_689 0833-0039 98 µM 0.64798489827309 0.231459171630141 no 791 0.258497358939518 1260 5374726
SGTC_1013 4112-3890 241 µM 0.646960591730442 0.231780980205432 no 792 0.258828724468257 1227 705171
SGTC_3234 9132280 49.47 µM 0.646153060049056 0.232034859776933 no 793 0.259090117691153 1269 17612295
SGTC_782 0083-0095 30.5 µM 0.64423786493821 0.232637595787363 no 794 0.259710600294136 1278 3591729 An indicator and reagent.
SGTC_2136 5328288 199.296 µM 0.643071917270003 0.233004959979375 no 795 0.260088717837526 1251 262395
SGTC_1224 0823-0416 294 µM 0.642694725950443 0.233123873513619 no 796 0.26021110194471 1321 3598164
SGTC_59 0330-0160 1.33 µM 0.642225129307046 0.233271965872242 no 797 0.260363509497771 1277 4293482
SGTC_171 k064-0041 9.68 µM 0.640847057969099 0.233706856779423 no 798 0.26081102776609 1239 53325
SGTC_41 0478-0632 82.643 µM 0.640782532373307 0.233727230736476 no 799 0.260831991660514 1273 3750424
SGTC_1444 4112-3581 28 µM 0.640137360763644 0.233930997802061 no 800 0.261041650854764 1293 2877249
SGTC_2370 9071495 200 µM 0.639891363690729 0.23400871792717 no 801 0.261121614485101 1230 21791103
SGTC_3141 9094609 49.47 µM 0.637924279509735 0.234630711172289 no 802 0.261761485990413 1250 25236309 YDL196W YDL196W
SGTC_2192 5915882 198.485 µM 0.63704074210086 0.234910383531118 no 803 0.262049152858972 1236 2876149
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.636862474705283 0.234966834099865 no 804 0.26210721375758 1247 279621
SGTC_3155 9099265 49.47 µM 0.635899757626558 0.235271819835951 no 805 0.262420880332488 1257 25236499
SGTC_2558 carylophyllene oxide 100 µM 0.634906435714248 0.235586730046451 no 806 0.26274471972402 1339 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.632792551489868 0.236257662435733 no 807 0.263434560743113 1275 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2789 5281112 71.43 µM 0.632627406466825 0.236310122612769 no 808 0.263488492771643 1280 765948
SGTC_1308 1187-1617 41.4 µM 0.631268311787319 0.236742097847754 no 809 0.263932551334684 1290 2882570
SGTC_1123 mangostin 811.285 nM 0.63104686501762 0.236812523707672 no 810 0.264004941015429 1296 5281650 An antioxidant.
SGTC_3120 9124077 49.47 µM 0.630837584714696 0.236879090900073 no 811 0.26407336284612 1331 18774327 YGL155W CDC43
SGTC_458 nppb 133 µM 0.629444264497457 0.237322535762158 no 812 0.264529123344614 1370 4549 A chloride channel blocker.
SGTC_1631 benzylvanillin 81.9 µM 0.625465994827055 0.238591184608817 no 813 0.265832630007205 1316 75506
SGTC_2197 6588183 93.1375 µM 0.625235945172783 0.238664659562815 no 814 0.265908106761701 1277 884136
SGTC_3016 9080866 49.47 µM 0.624456653016532 0.238913647622312 no 815 0.266163864591216 1297 17066299
SGTC_540 1187-0821 17.3 µM 0.623615101847175 0.239182687221109 no 816 0.266440195164891 1294 847520
SGTC_1388 3346-4487 254 µM 0.623071474619885 0.239356570040219 no 817 0.266618776972076 1368 3345614
SGTC_1867 st057372 64 µM 0.622483672787288 0.239544660067953 no 818 0.266811938230619 1302 688837
SGTC_2602 kawain 100 µM 0.621445727356066 0.239876987978044 no 819 0.267153196604987 1277 5369129
SGTC_3293 9120939 62.045 µM 0.620743511886728 0.240101964885061 no 820 0.267384197707715 1330 934087
SGTC_2995 9067767 71.4286 µM 0.619576641879858 0.240476062785125 no 821 0.267768274459335 1320 11673567
SGTC_921 1561-0023 372 µM 0.619178091528125 0.240603910501619 no 822 0.267899521472573 1310 24050882
SGTC_3189 9110682 49.47 µM 0.619131379276518 0.240618897366037 no 823 0.267914906451682 1345 17122418
SGTC_1009 4106-0057 9.87 µM 0.61893846512715 0.240680796108657 no 824 0.26797844867483 1316 2928005
SGTC_1314 1222-0010 41.1 µM 0.617337839453034 0.241194709546206 no 825 0.268505956601071 1309 3526027
SGTC_1163 k060-0048 49.9 µM 0.614834587954992 0.241999623748275 no 826 0.269331982360241 1318 6809982
SGTC_2921 7974240 10.71 µM 0.612741697868623 0.242673703912973 no 827 0.270023573274917 1346 2979074 YDR527W RBA50
SGTC_1714 st033236 13.627 µM 0.612373332075428 0.242792452657549 no 828 0.270145390839882 1393 2916566
SGTC_3341 9147222 25.867 µM 0.611138511669328 0.243190746538042 no 829 0.270553942999304 1311 1939759
SGTC_2517 totarol 10 µM 0.610452478846393 0.243412180396786 no 830 0.270781056832455 1276 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2940 9060638 45.86 µM 0.610334156868513 0.24345038271856 no 831 0.270820237403989 1351 4027022
SGTC_416 estradiol valerate 100 µM 0.610260625936044 0.243474125099146 no 832 0.270844587509468 1327 13791 A steroid.
SGTC_1236 0330-0013 258 µM 0.609389954265804 0.243755351083969 no 833 0.271132997473243 1299 4617066
SGTC_914 3820-6779 408 µM 0.606376637786814 0.244730001087375 no 834 0.27213233915996 1305 2893481
SGTC_1373 2887-0003 58.5 µM 0.604042935752242 0.245486270727178 no 835 0.272907548432272 1328 776948
SGTC_1835 st008666 49.2 µM 0.601982002676752 0.246155188331473 no 836 0.273593058676909 1304 690455
SGTC_2311 7694451 200 µM 0.601891743054146 0.246184506247866 no 837 0.273623100414877 1359 2163142
SGTC_931 2812-0076 566 µM 0.601817116575929 0.246208747657458 no 838 0.273647940097234 1348 3450959
SGTC_1630 st005209 31.3 µM 0.601554052171859 0.246294210805046 no 839 0.273735510894544 1345 3367314
SGTC_1485 3909-9022 254 µM 0.600178663517662 0.246741299536097 no 840 0.274193585861576 1333 714516
SGTC_2368 9071271 200 µM 0.600158637605985 0.246747812438316 no 841 0.274200258312726 1303 27209959
SGTC_3127 9126946 49.47 µM 0.599695370414591 0.246898503625351 no 842 0.274354637098587 1296 27243249
SGTC_2555 cholic acid 100 µM 0.599595625462629 0.246930955027591 no 843 0.274387881638901 1328 6708657 Influences liver metabolism.
SGTC_2929 9013348 24.6 µM 0.597555754193005 0.247595114895525 no 844 0.275068197307534 1348 2995952
SGTC_208 k072-0098 12.366 µM 0.596989804120908 0.247779551031226 no 845 0.275257093937553 1334 5948901
SGTC_3109 9122853 49.47 µM 0.596892834258089 0.247811159670625 no 846 0.275289465885216 1408 1234709
SGTC_1649 st011737 51.3 µM 0.596676595987126 0.247881653213835 no 847 0.275361660566262 1336 1761035
SGTC_664 1222-0054 14.9 µM 0.596284326840829 0.248009560028951 no 848 0.275492649807795 1335 6813991
SGTC_194 1486-1323 56.904 µM 0.595759357750061 0.248180791269477 no 849 0.275667999080214 1316 5178754
SGTC_2520 obtusaquinone 4.71 µM 0.59465024618613 0.248542761783864 no 850 0.27603864293319 1417 5967872
SGTC_961 1252-1571 372 µM 0.5942359927358 0.248678029974532 no 851 0.276177141244994 1408 6813498
SGTC_3156 9099931 49.47 µM 0.593977057488369 0.248762601267377 no 852 0.276263728982293 1400 18111053
SGTC_2833 9001315 45.46 µM 0.59362902670623 0.24887629632871 no 853 0.276380131174372 1390 2989378
SGTC_2807 7945238 51.95 µM 0.593564229908389 0.248897467268504 no 854 0.276401805733324 1385 17148797
SGTC_599 1935-0052 86.5 µM 0.59248957997604 0.249248725420418 no 855 0.276761398153471 1326 9557311
SGTC_2389 9091542 195.52 µM 0.591332577950204 0.249627195495122 no 856 0.277148802722888 1337 3626624 YOL127W RPL25
SGTC_793 0488-0545 106 µM 0.590317922237176 0.249959353350738 no 857 0.277488763019372 1314 292548
SGTC_1458 k015-0034 6.33 µM 0.588819813891929 0.25045020282426 no 858 0.27799107638977 1293 3598957
SGTC_520 3584-0023 682 µM 0.588412752428365 0.250583663160128 no 859 0.278127640078246 1330 1340790
SGTC_1647 st011722 22.4 µM 0.587532400181143 0.250872426769537 no 860 0.278423098368969 1358 2854783
SGTC_1979 st071809 45.3 µM 0.586891776192189 0.25108266798553 no 861 0.278638196666496 1421 4976333
SGTC_445 e6 berbamine 66 µM 0.585872802910665 0.251417268545403 no 862 0.278980497560143 1382 6610268 A calcium/calmodulin antagonist.
SGTC_1503 4585-0012 61.3 µM 0.585166844640941 0.251649222396625 no 863 0.279217768062121 1398 2922052
SGTC_346 4513-0042 7.16 µM 0.584905064463905 0.251735263168782 no 864 0.279305776532443 1361 2827372
SGTC_2700 st077718 96.8 µM 0.584389240384187 0.251904847439907 no 865 0.279479232033711 1358 904970
SGTC_967 1306-0166 352 µM 0.584042405155714 0.252018908191972 no 866 0.279595891275383 1371 4437607
SGTC_598 3937-0236 20.2 µM 0.583800863667141 0.252098357981219 no 867 0.279677148560592 1396 1379313
SGTC_2918 7977171 22.06 µM 0.583006866908797 0.252359618921624 no 868 0.279944338768249 1310 2236483
SGTC_2867 9039098 71.43 µM 0.582220711762669 0.252618440164685 no 869 0.280209012057839 1329 6463460
SGTC_2240 6690706 185.951 µM 0.579210844528904 0.253610652075615 no 870 0.281223457173094 1288 805876
SGTC_1848 st056003 16.4 µM 0.577515158510191 0.254170540293071 no 871 0.28179575078948 1405 146492
SGTC_262 fenpropimorph 62.5 µM 0.576931610913144 0.254363368128256 no 872 0.281992827699637 1323 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_236 1509-0011 5.31 µM 0.576596648884934 0.254474087820611 no 873 0.282105981754734 1408 3107280
SGTC_1184 1269-1718 139 µM 0.576045359499686 0.254656368193243 no 874 0.282292261281892 1464 5403821
SGTC_174 3553-0389 74.3 µM 0.57398628859494 0.255337791238561 no 875 0.282988539899251 1388 738071
SGTC_3243 9134147 49.47 µM 0.573113990703023 0.255626754146849 no 876 0.28328375745124 1416 24282180
SGTC_2340 7987427 183.45 µM 0.57157916068949 0.256135605948534 no 877 0.283803558434053 1403 2239331
SGTC_2781 5567276 71.43 µM 0.570901713536598 0.256360372159127 no 878 0.284033134675717 1418 2853274
SGTC_909 3448-9333 149 µM 0.566209120762727 0.257920117454693 no 879 0.285625815221583 1365 3344074
SGTC_843 0310-0051 143 µM 0.566012477843158 0.257985585836876 no 880 0.285692649108437 1399 2065037
SGTC_2665 lovastatin 100 µM 0.565704295013377 0.258088206570845 no 881 0.285797407515863 1368 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1850 st056238 17 µM 0.565670641654001 0.258099413968353 no 882 0.285808848170351 1369 5393177
SGTC_1348 1493-0373 93.8 µM 0.565516155411779 0.258150864929888 no 883 0.285861369457932 1410 3010129
SGTC_2171 5739187 198.077 µM 0.565485102082495 0.258161207746082 no 884 0.285871927332776 1323 2262761
SGTC_2221 6807166 181.081 µM 0.565337418448475 0.258210399121788 no 885 0.285922141082968 1369 674925
SGTC_1822 st052468 42 µM 0.565047807355179 0.258306878675998 no 886 0.28602062360439 1355 2873678
SGTC_637 1181-0519 7.26 µM 0.561681574073634 0.259429657377293 no 887 0.287166495302516 1386 6252091 YGR060W ERG25
SGTC_3094 9117742 49.47 µM 0.5608901659093 0.259693990423652 no 888 0.287436207210051 1337 17149698
SGTC_2323 6148992 148.28 µM 0.559405922126567 0.260190107512678 no 889 0.287942360299837 1364 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1730 st033808 45.1 µM 0.558615887695887 0.260454380163852 no 890 0.288211947359785 1447 1045166
SGTC_537 1334-0398 209 µM 0.554456856691946 0.261847884135363 no 891 0.289633112018877 1448 5846986
SGTC_1445 4239-0156 97.7 µM 0.553012999581346 0.262332548261714 no 892 0.290127254343356 1540 4008346
SGTC_2667 digitoxin 100 µM 0.552134676184959 0.262627602470331 no 893 0.290428042849426 1395 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_62 0180-0423 3.232 µM 0.551909942900189 0.262703124148523 no 894 0.290505027914907 1363 30102 YGL099W LSG1
SGTC_2760 etidronate 98.04 µM 0.551169501099728 0.262952028388048 no 895 0.290758742626767 1380 3305 A chelator and antioxidant.
SGTC_2077 5212015 200 µM 0.549597439081298 0.263480886486266 no 896 0.291297757862448 1314 780900
SGTC_2678 equilin 100 µM 0.549126281264003 0.263639494573256 no 897 0.291459395227718 1488 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_3089 9117425 49.47 µM 0.548332645506369 0.263906770018158 no 898 0.291731757768387 1342 9401657
SGTC_839 0122-0028 230 µM 0.548249036263062 0.26393493543077 no 899 0.291760457969304 1412 759448
SGTC_786 4544-0069 423 µM 0.548106176920162 0.263983063946238 no 900 0.291809499752455 1474 748821 YLR208W SEC13
SGTC_2117 5521686 200 µM 0.543756664833126 0.26545052826972 no 901 0.293304466598785 1381 803312
SGTC_139 0099-0334 718.624 µM 0.543378831719307 0.265578198979825 no 902 0.293434498669055 1442 97690
SGTC_2214 7179297 48.276 µM 0.543233671854346 0.265627257124267 no 903 0.293484462845455 1465 769744
SGTC_2506 ethyl hematommate 54.16 µM 0.542342443863552 0.265928556714281 no 904 0.293791310775268 1368 3940691 An allergen.
SGTC_1969 st069479 40.1 µM 0.539252864202249 0.266974397245491 no 905 0.294856194041305 1498 3895485
SGTC_462 ag-879 158 µM 0.538789920326211 0.267131285187259 no 906 0.295015909725135 1486 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2312 7706453 155.7 µM 0.538723267441703 0.26715387714399 no 907 0.295038908258728 1424 976098
SGTC_89 0302-0250 142.109 µM 0.536339148082915 0.267962606747337 no 908 0.29586208957868 1489 4203518 YLR208W SEC13
SGTC_647 0140-0236 81 µM 0.535090568383801 0.268386635322384 no 909 0.296293615749461 1468 990837
SGTC_1937 st074714 47.2 µM 0.534877841350738 0.268458912910347 no 910 0.296367165880203 1384 17250970
SGTC_1421 4029-0249 71.4 µM 0.533624901221887 0.268884818872147 no 911 0.296800538246895 1519 2894095
SGTC_997 3996-0078 137 µM 0.531797353363997 0.269506656265074 no 912 0.297433178015019 1447 735687
SGTC_2088 5278280 127.392 µM 0.531660823744258 0.269553140448343 no 913 0.297480465001952 1455 791502
SGTC_2515 chrysin 20.77 µM 0.531649200354902 0.269557098044489 no 914 0.297484490917429 1490 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2003 4023581 200 µM 0.531249286948263 0.269693280513664 no 915 0.297623021394572 1457 16641307
SGTC_2689 tacrolimus 100 µM 0.530985716972146 0.269783052805942 no 916 0.297714338439445 1445 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_190 3970-0790 3.722 µM 0.530017162457773 0.270113072263567 no 917 0.298050015751807 1487 2832352
SGTC_2853 9015042 58.44 µM 0.529358660850477 0.270337561419773 no 918 0.298278334751818 1363 6457456
SGTC_2325 6158266 200 µM 0.528298158010146 0.270699292374524 no 919 0.298646204945735 1432 3623240
SGTC_1803 st050068 52.4 µM 0.528151363246216 0.270749382195904 no 920 0.298697141774575 1504 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2752 diclazuril 33.15 µM 0.527186714993341 0.271078657910754 no 921 0.2990319666588 1466 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_962 1254-0300 21.5 µM 0.525183893568818 0.271762943728691 no 922 0.299727680227494 1454 7340576
SGTC_3052 9092717 49.47 µM 0.524484666938947 0.272002044439519 no 923 0.29997074084111 1435 25237534
SGTC_952 1185-0122 232 µM 0.522415248451086 0.272710294997739 no 924 0.300690620696951 1382 678600
SGTC_2960 9079389 5.97 µM 0.5219099075642 0.27288338489561 no 925 0.300866529870985 1544 16457355
SGTC_901 1112-0062 60.1 µM 0.521741847895044 0.272940960942813 no 926 0.300925041728865 1457 1908457
SGTC_2824 7998404 51.95 µM 0.521116901256438 0.273155116049271 no 927 0.301142668911303 1472 837851
SGTC_3171 9103192 49.47 µM 0.520703643671072 0.273296775815255 no 928 0.301286617872059 1485 13018434
SGTC_48 0382-0018 55 µM 0.519572673881099 0.273684644715995 no 929 0.301680724042322 1573 762596
SGTC_378 3970-0959 8.33 µM 0.518967111380559 0.273892435762965 no 930 0.301891838116643 1459 6615653
SGTC_1907 st060210 83.7 µM 0.517508804641702 0.274393154965205 no 931 0.302400512139695 1534 688793
SGTC_1141 3253-0389 52.6 µM 0.516268836448515 0.274819261320382 no 932 0.302833329310739 1450 5402031
SGTC_795 0685-0265 78 µM 0.515572981602385 0.275058529748407 no 933 0.303076342408946 1473 302754
SGTC_291 SEC14.278 35.5 µM 0.515564044448125 0.275061603439965 no 934 0.303079464094958 1530 1068044
SGTC_1473 k844-0725 134 µM 0.515157951347122 0.275201285983197 no 935 0.303221324772061 1496 54682906
SGTC_1336 1486-0901 104 µM 0.514408646720251 0.275459113530109 no 936 0.303483157573969 1492 5006114
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.514006225905437 0.275597631170291 no 937 0.303623818914648 1474 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1530 rhein 70.4 µM 0.513600324591518 0.275737381523684 no 938 0.303765726298697 1483 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_3055 9094636 49.47 µM 0.513191338623779 0.275878229131153 no 939 0.303908742035024 1509 25236176
SGTC_2981 9013952 38.96 µM 0.512038070712156 0.276275584664318 no 940 0.304312182674154 1353 2996344
SGTC_1201 1889-3372 45.9 µM 0.510856159324616 0.276683100380711 no 941 0.304725890742017 1449 5392199
SGTC_987 1497-1013 404 µM 0.510594219717775 0.276773455389841 no 942 0.30481761210554 1461 1676435
SGTC_209 4077-0173 175.592 µM 0.510461403995535 0.276819275158734 no 943 0.30486412384598 1440 15993494
SGTC_2650 prasterone 100 µM 0.510438163101001 0.276827293359635 no 944 0.304872263074494 1447 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2415 st077333 57.7 µM 0.510134989254801 0.276931899959872 no 945 0.30497844688565 1690 2766255
SGTC_2961 9083290 32.55 µM 0.51010629517155 0.276941801521182 no 946 0.304988497571491 1496 17741490
SGTC_1700 st030840 7.9285 µM 0.509596436285721 0.277117769095049 no 947 0.30516711053399 1550 5499307
SGTC_183 3914-0051 30.55 µM 0.509590754815717 0.277119730248722 no 948 0.305169101119164 1576 1596232
SGTC_1819 st053448 58.6 µM 0.508560834923572 0.277475354482341 no 949 0.305530043615305 1488 2857616
SGTC_246 cycloheximide 667 µM 0.507552413122405 0.27782377156004 no 950 0.305883635182976 1412 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_3133 9127736 49.47 µM 0.507389864406293 0.277879953309096 no 951 0.305940647979094 1518 27243420
SGTC_2482 5981709 142.65 µM 0.507351936661611 0.277893063081894 no 952 0.305953951540115 1505 877755
SGTC_821 1114-0266 29.2 µM 0.507071458658574 0.277990020027605 no 953 0.306052340137054 1449 3123235
SGTC_1247 0448-0043 5.84 µM 0.504553818553381 0.278861067952514 no 954 0.306936126473993 1480 3089013 YGL099W LSG1
SGTC_1886 st057356 49.9 µM 0.503005530541657 0.279397400135309 no 955 0.307480191897241 1421 24207747
SGTC_1134 3477-0009 42.5 µM 0.500609025057171 0.280228544424227 no 956 0.308323154776436 1656 3973534
SGTC_783 0848-0141 92.7 µM 0.499632311561073 0.280567626632015 no 957 0.308667000973547 1454 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2534 helenine 20.12 µM 0.498060366687468 0.281113769787618 no 958 0.309220747173595 1498 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1602 st001878 87.6 µM 0.497377433823051 0.28135120208122 no 959 0.309461457912701 1506 595405 YLR310C CDC25
SGTC_2089 5281248 129.67 µM 0.496331793009109 0.281714922913243 no 960 0.309830169368148 1470 2737878
SGTC_1750 st081859 2.357 µM 0.495746433736496 0.281918636075281 no 961 0.310036660993209 1516 5291695
SGTC_2397 5161689 200 µM 0.491953382294294 0.283240387719135 no 962 0.311376149691526 1570 2259942
SGTC_1072 oxiconazole 14.9 nM 0.491585243990856 0.2833688296927 no 963 0.311506288498394 1519 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1787 fluconazole 80 µM 0.488089140602278 0.284589995923795 no 964 0.312743351314318 1428 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2883 9059145 45.46 µM 0.487873621811297 0.284665357395405 no 965 0.312819679834155 1475 16476510
SGTC_1560 lithocholic acid 53.1 µM 0.487361223247633 0.284844568458103 no 966 0.313001184044321 1501 9903 A bile acid which acts as a detergent.
SGTC_2898 9056270 58.44 µM 0.486368227894228 0.285192021090688 no 967 0.313353056507571 1488 19154699
SGTC_1309 pyrazolanthrone 13.4 µM 0.486079699810855 0.285293015956991 no 968 0.313455329641349 1599 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_326 k292-0812 17.5 µM 0.485952676102087 0.285337484074933 no 969 0.313500359660115 1535 3579357
SGTC_2270 7924575 90.91 µM 0.485691250247974 0.285429013722009 no 970 0.313593044106798 1633 1262135
SGTC_1427 4048-4900 550 nM 0.485633619894178 0.285449192971641 no 971 0.313613477630499 1577 24132586
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.485330684538889 0.285555276856155 no 972 0.313720896347182 1545 279621
SGTC_1774 st048371 48.465 µM 0.484387540326967 0.285885673367658 no 973 0.314055429658093 1460 4242727
SGTC_2354 9060492 162 µM 0.48359664624808 0.286162874578555 no 974 0.314336077688839 1619 6471895
SGTC_203 k066-0004 30.888 µM 0.480104101766495 0.287388504019758 no 975 0.315576685876723 1571 6795412
SGTC_3192 9110362 49.47 µM 0.478689329582876 0.287885691990545 no 976 0.316079828961891 1564 16649480
SGTC_2382 9035899 200 µM 0.478541904845301 0.287937524261377 no 977 0.316132278042375 1517 6462679
SGTC_2750 bromebric acid 70.15 µM 0.473264832632837 0.289795756782689 no 978 0.318012124307813 1569 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_3190 9110366 49.47 µM 0.473230179912531 0.289807977729783 no 979 0.318024484192177 1616 17123768
SGTC_383 2324-0395 7.37 µM 0.472462373761785 0.290078821316597 no 980 0.318298396206818 1583 3146421
SGTC_421 streptovitacin 30 mM 0.471097859436049 0.290560446231064 no 981 0.318785426831887 1537 91467 include heat shock
SGTC_2588 indole-3-carbinol 100 µM 0.469756479579438 0.291034269897131 no 982 0.319264505421618 1645 3712 Induces cell cycle arrest.
SGTC_3208 9114115 49.47 µM 0.467923435615852 0.291682350059837 no 983 0.319919671747928 1452 650895
SGTC_3258 9138477 49.47 µM 0.467547260937148 0.291815431290119 no 984 0.320054193631738 1562 4970355
SGTC_528 3492-0019 172 µM 0.467528200138233 0.291822175278873 no 985 0.320061010495554 1543 2869262
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.465919009466916 0.292391792056422 no 986 0.320636736904697 1562 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_105 0111-0055 734.78 µM 0.465029793772255 0.292706775718425 no 987 0.320955060373715 1517 5179370
SGTC_549 1661-1316 519 µM 0.464309853847296 0.29296191282708 no 988 0.321212882573249 1635 2857282
SGTC_1780 st038448 24.544 µM 0.464057921483505 0.293051218664738 no 989 0.3213031240162 1641 728868 YDL195W SEC31
SGTC_2626 ethyl orsellinate 100 µM 0.46364028058006 0.293199293240121 no 990 0.321452745018809 1491 75653 A natural product.
SGTC_781 4335-2806 94.4 µM 0.462799070762073 0.29349764942107 no 991 0.321754198684435 1657 845254
SGTC_2557 derrustone 83.84 µM 0.462791070187993 0.293500487700444 no 992 0.321757066312206 1485 629853 An antioxidant.
SGTC_2030 5175110 200 µM 0.461832531402373 0.293840630365511 no 993 0.322100710011486 1592 2831986
SGTC_1616 st002734 56.1 µM 0.458899111563685 0.294882701464178 no 994 0.323153308399276 1560 4026101
SGTC_3263 9137018 49.47 µM 0.458789117877268 0.294921808844802 no 995 0.323192805034084 1463 43844957
SGTC_2453 5731132 22.18 µM 0.458779787397401 0.294925126332697 no 996 0.323196155523153 1659 1362040
SGTC_825 1988-2224 89.6 µM 0.45835784649164 0.295075167008682 no 997 0.323347685587756 1538 1180859
SGTC_3249 9135183 49.47 µM 0.457272051147318 0.295461433493286 no 998 0.323737757923411 1567 4902779
SGTC_167 3672-0051 66.205 µM 0.454976631817748 0.296278782460717 no 999 0.324563025282699 1480 3237971
SGTC_379 3970-0972 5.9 µM 0.453891917973211 0.296665385944394 no 1000 0.324953310448475 1572 2898042 YBL034C STU1
SGTC_23 0213-0011 39.996 µM 0.453266217859271 0.296888497097586 no 1001 0.325178527739376 1625 627608
SGTC_3007 9078383 71.4286 µM 0.451800785899159 0.297411338762664 no 1002 0.325706251750999 1555 6496995
SGTC_1755 st041960 45.185 µM 0.450612212893412 0.297835710393989 no 1003 0.326134531447685 1560 2257073
SGTC_1521 st012942 49.4 µM 0.450156754441401 0.29799840178316 no 1004 0.326298708078736 1741 24207259
SGTC_2245 6637752 200 µM 0.449663951939087 0.298174478208611 no 1005 0.326476383833325 1685 681890
SGTC_1379 2144-0755 36.5 µM 0.449498032306349 0.298233771312159 no 1006 0.326536213609276 1627 5392327
SGTC_2647 atorvastatin 60.16 µM 0.448877651543181 0.298455518374968 no 1007 0.326759959282407 1610 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_358 0075-0058 9.45 µM 0.448455274934975 0.298606534332272 no 1008 0.32691232870985 1784 1069125
SGTC_375 3970-0961 9.27 µM 0.447678168159727 0.298884470773482 no 1009 0.327192739970618 1576 2898222
SGTC_1857 st056007 79.3 µM 0.447673294065232 0.298886214390577 no 1010 0.327194499047248 1562 619834
SGTC_2828 7998861 71.43 µM 0.447531630425463 0.298936893954663 no 1011 0.327245627594595 1668 2988188
SGTC_2540 epiandrosterone 100 µM 0.44608573517337 0.299454379898622 no 1012 0.32776765827344 1577 441302 A steroid.
SGTC_2502 avocadyne acetate 18.59 µM 0.445907980381731 0.29951802636674 no 1013 0.327831858702424 1514 3952079
SGTC_1253 0550-0034 176 µM 0.44543905419975 0.299685958403048 no 1014 0.328001247115317 1548 5969915
SGTC_983 1491-0821 12.2 µM 0.444355517483109 0.300074158057109 no 1015 0.328392784239939 1641 46495113
SGTC_632 0781-2353 4.65 µM 0.444299397567468 0.300094270383035 no 1016 0.328413068369272 1590 6811515 YHR007C ERG11
SGTC_3280 9140961 49.47 µM 0.443998028082935 0.300202285984986 no 1017 0.328522004794745 1550 4901226
SGTC_1300 1094-0077 113 µM 0.443955449191653 0.300217548351908 no 1018 0.328537397018257 1528 5532636
SGTC_2079 5212404 121 µM 0.443393724923867 0.300418930765223 no 1019 0.328740486969286 1658 758462
SGTC_609 0986-0026 86.3 µM 0.442621271048995 0.30069596095962 no 1020 0.329019848268484 1612 2848610
SGTC_1033 k072-0102 21.3 µM 0.441705721078063 0.30102445986843 no 1021 0.329351084597618 1678 5965931
SGTC_674 0498-0004 451 µM 0.440593664111135 0.301423682822938 no 1022 0.329753595266243 1525 4231473
SGTC_2732 terfenadine 20 µM 0.437184501466278 0.3026490377667 no 1023 0.330988774347659 1573 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2933 9026794 32.47 µM 0.436923586291047 0.302742910361123 no 1024 0.331083382977956 1623 17586027
SGTC_2839 9003951 25.97 µM 0.435872846883552 0.303121079469915 no 1025 0.33146449338704 1602 2990634
SGTC_1943 st076331 65.2 µM 0.433079310028065 0.304127520665616 no 1026 0.33247857658875 1619 24208415
SGTC_671 0560-0003 407 µM 0.432351733778697 0.304389892335918 no 1027 0.332742896166041 1630 3238678
SGTC_2862 9027634 71.43 µM 0.432247321328707 0.304427552832936 no 1028 0.332780834761615 1500 5012562
SGTC_3162 9099653 49.47 µM 0.430188173239938 0.30517068969341 no 1029 0.333529382198136 1604 25237511
SGTC_2642 cholecalciferol 100 µM 0.429873249272721 0.30528441522583 no 1030 0.333643922815042 1620 9821465 A vitamin D precursor, similar to steriods.
SGTC_386 1509-0011 3.07 µM 0.428235415724399 0.305876173579313 no 1031 0.334239867114779 1580 3107280
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.426686868212991 0.306436138907527 no 1032 0.334803708258832 1541 4174840
SGTC_2234 tolnaftate 200 µM 0.426352584908755 0.306557077429238 no 1033 0.334925472992956 1605 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_982 1491-0518 27.5 µM 0.425628048739878 0.306819275700354 no 1034 0.335189449274619 1600 3091256
SGTC_3051 9093778 49.47 µM 0.424741398553812 0.307140275006154 no 1035 0.335512600673678 1601 17217378
SGTC_2724 maprotiline 69.64 µM 0.424298794503283 0.307300568956438 no 1036 0.335673959139076 1648 4011 A tricyclic antidepressant.
SGTC_2224 6650123 117.647 µM 0.421238531291182 0.308409883192153 no 1037 0.33679045535655 1599 2908370
SGTC_1684 st024538 14.6195 µM 0.419553710127923 0.309021362028293 no 1038 0.337405755152955 1576 6732859
SGTC_1794 st048918 76.9 µM 0.419464006003409 0.309053933565535 no 1039 0.337438527476824 1680 672303
SGTC_484 loperamide 105 µM 0.419413197768816 0.309072382684281 no 1040 0.337457090201794 1600 3955 An opioid-receptor agonist.
SGTC_1632 st005650 90 µM 0.419207029357866 0.309147250008146 no 1041 0.337532417631692 1597 2759605
SGTC_1366 1683-0113 21.9 µM 0.416142949042499 0.310260863082413 no 1042 0.33865270183903 1586 708623
SGTC_1248 0469-0687 58.6 µM 0.415885098970633 0.310354656030231 no 1043 0.338747041900518 1681 4017482
SGTC_2476 5806916 10.51 µM 0.415657730050457 0.3104373716949 no 1044 0.338830238163251 1651 2870194
SGTC_3343 9148379 18.9835 µM 0.415560872630442 0.310472610847253 no 1045 0.338865681522961 1736 1955036
SGTC_1874 staurosporine 7.6 µM 0.414853706708973 0.310729948197789 no 1046 0.339124500328679 1673 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_3135 9127742 49.47 µM 0.413467368267965 0.311234704800549 no 1047 0.339632112777507 1595 3643468
SGTC_2662 daunorubicin 22.37 µM 0.412843695050145 0.311461895957595 no 1048 0.339860567776157 1571 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1739 st037196 92.5 µM 0.410879773736171 0.312177780369231 no 1049 0.340580347130803 1761 612214
SGTC_1831 st055328 12 µM 0.410130837821618 0.312450967990949 no 1050 0.340854986145861 1706 1103068
SGTC_1902 st060212 70.5 µM 0.409333670576767 0.312741862128635 no 1051 0.341147404554942 1584 688944
SGTC_1675 st018485 24.5 µM 0.409207011080903 0.312788092165037 no 1052 0.341193874822984 1615 3323024
SGTC_1171 0368-0077 21.4 µM 0.40870533014063 0.312971231942387 no 1053 0.341377960856871 1589 3239779
SGTC_768 0384-0033 77.3 µM 0.408648508783805 0.312991977619952 no 1054 0.341398813178891 1573 3965305 YMR134W ERG29
SGTC_866 0495-0101 262 µM 0.408626414559531 0.313000044458961 no 1055 0.341406921456027 1548 635694
SGTC_3024 9090631 49.47 µM 0.408348254307022 0.31310161141727 no 1056 0.34150900871303 1716 25236383
SGTC_2956 9076196 2.52 µM 0.405875166539725 0.314005253332645 no 1057 0.342417162777664 1633 16423868
SGTC_2822 7994718 71.43 µM 0.403828877479509 0.314753791617524 no 1058 0.343169279823761 1652 1018011
SGTC_3206 9114350 49.47 µM 0.401833515865531 0.315484434253287 no 1059 0.343903277170897 1589 17087243
SGTC_2644 guaiazulene 100 µM 0.400537019724641 0.315959560121829 no 1060 0.344380511309419 1688 3515 A coloring agent.
SGTC_1952 st077036 64.1 µM 0.400030815318903 0.316145151043285 no 1061 0.344566910097802 1592 2937007
SGTC_3311 9131146 2.8755 µM 0.397742178236041 0.316984817235633 no 1062 0.345410121604088 1617 4900406 YPR165W RHO1
SGTC_2670 beta-carotene 100 µM 0.396402686100531 0.317476694517425 no 1063 0.345903992413404 1650 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1176 0848-0131 83.3 µM 0.3962257805889 0.317541680427516 no 1064 0.345969237108217 1765 6769040
SGTC_11 0438-0307 1.3 µM 0.395377960393802 0.317853203619517 no 1065 0.346281985954508 1726 4011476
SGTC_1441 4106-0040 13 µM 0.394293552733436 0.318251846500802 no 1066 0.346682161362056 1632 2904180
SGTC_973 1325-0077 65.9 µM 0.390663211855215 0.319587939286871 no 1067 0.34802309740777 1761 2835149
SGTC_3035 9091303 49.47 µM 0.389714086424941 0.319937638150392 no 1068 0.348373989520433 1653 25237002
SGTC_1113 artemisinin 1.17947 µM 0.388897807951141 0.3202385184984 no 1069 0.348675871892985 1763 2240 An anti-malaria and mitochondrial poison.
SGTC_1978 st071761 42 µM 0.387995747154833 0.320571155744256 no 1070 0.349009590421263 1595 5147680
SGTC_1564 D-Arginine 115 µM 0.387272752035381 0.320837866153292 no 1071 0.34927714772535 1547 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2845 9003024 42.97 µM 0.385817124105762 0.321375122747627 no 1072 0.349816056092077 1725 2990173
SGTC_1789 tunicamycin 25 nM 0.384825209618042 0.321741442018982 no 1073 0.35018346011879 1692 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1767 st044992 70.3 µM 0.384325408845076 0.321926086793474 no 1074 0.350368638936164 1582 9600693
SGTC_2762 leflunomide 42.06 µM 0.382713552166793 0.322521865300217 no 1075 0.350966082477803 1674 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_559 1550-0661 158 µM 0.382140766021993 0.32273368985332 no 1076 0.351178477662018 1702 5830875
SGTC_2852 9023854 51.95 µM 0.381462306610267 0.32298466833371 no 1077 0.351430117764193 1718 19798528
SGTC_1642 st009582 77.7 µM 0.380811622051039 0.323225447972804 no 1078 0.351671517384472 1771 6739311
SGTC_1210 3013-0140 750 nM 0.379884954106008 0.323568480488511 no 1079 0.352015408238978 1782 905973
SGTC_2378 9074213 121.43 µM 0.378912377118976 0.323928668861912 no 1080 0.352376466378157 1639 657714
SGTC_859 0439-0102 54.6 µM 0.378731809134687 0.323995559353436 no 1081 0.35244351484393 1767 610143
SGTC_2925 9010536 32.5 µM 0.378038208440489 0.324252553032291 no 1082 0.352701105125968 1737 2994177
SGTC_68 0986-0284 82.829 µM 0.376064687121687 0.324984242123665 no 1083 0.353434403096876 1568 423278 YIL048W NEO1
SGTC_2806 7952793 58.44 µM 0.375227020020588 0.325295014173198 no 1084 0.353745818370215 1687 2972490
SGTC_1073 triclabendazole 3.09 µM 0.374927626865497 0.325406117653592 no 1085 0.353857146011179 1694 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2345 9052315 157.45 µM 0.374349328090946 0.325620765708997 no 1086 0.35407221849525 1668 6469265
SGTC_2385 9074692 200 µM 0.373801743953883 0.325824066676654 no 1087 0.35427591095938 1630 17046906
SGTC_3270 9137563 49.47 µM 0.37182457982115 0.326558557105388 no 1088 0.355011730824687 1730 17015724
SGTC_281 1672-3440 14.9 µM 0.371270107973877 0.326764657021719 no 1089 0.355218179900447 1716 6833000
SGTC_2388 9080168 200 µM 0.36923495417072 0.327521586480241 no 1090 0.355976302052755 1595 15943073
SGTC_718 1130-0073 349 µM 0.369173697287684 0.327544380607888 no 1091 0.355999129913873 1736 6740020
SGTC_2707 st078556 66.6 µM 0.368286216907053 0.327874690538067 no 1092 0.356329914366451 1791 17250899
SGTC_286 k060-0067 22.9 µM 0.368285385671948 0.327874999977335 no 1093 0.356330224237712 1664 5985051
SGTC_686 1319-0111 510 µM 0.367786461545234 0.32806075300232 no 1094 0.356516232346949 1775 4562600
SGTC_3088 9117578 49.47 µM 0.367373968172897 0.328214359360437 no 1095 0.356670043257139 1704 678341
SGTC_2570 licareol 100 µM 0.367327753838871 0.328231570696925 no 1096 0.356687277153263 1639 443158
SGTC_858 0438-0351 2.77 µM 0.365718021948389 0.328831301139856 no 1097 0.357287748410777 1636 2799119
SGTC_1381 2324-0066 62.1 µM 0.364016789260151 0.329465600978384 no 1098 0.357922736110651 1695 10885928
SGTC_3239 9133757 49.47 µM 0.363860411589305 0.329523930622622 no 1099 0.357981124079857 1738 17036923
SGTC_2974 9094440 9.66 µM 0.363555351346279 0.329637731538836 no 1100 0.358095036399569 1767 25236134
SGTC_3074 9116018 49.47 µM 0.362873650321598 0.329892093071951 no 1101 0.358349635523377 1692 17027303
SGTC_2655 perillic acid 100 µM 0.3618176939743 0.330286254926778 no 1102 0.358744134426161 1661 5702197 An apoptosis inducer.
SGTC_338 4055-0136 114 µM 0.361420436814062 0.330434589792775 no 1103 0.358892586343465 1641 2900563
SGTC_1788 fluconazole 20 µM 0.361120576722161 0.330546574476726 no 1104 0.35900465585075 1647 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_129 0088-0017 176.636 µM 0.36100692350571 0.330589022968722 no 1105 0.359047135698877 1788 182446
SGTC_1620 st003704 16.5 µM 0.360765972257293 0.330679023380116 no 1106 0.359137201144069 1772 2834414
SGTC_878 0828-0289 13.7 µM 0.360085415388372 0.330933278696059 no 1107 0.359391629553503 1676 745350 YLR208W SEC13
SGTC_1328 1441-0025 69.2 µM 0.358833391090715 0.331401237309225 no 1108 0.35985986573839 1588 4562601
SGTC_2200 6600604 21.907 µM 0.358569614193606 0.331499860596053 no 1109 0.359958540750021 1677 2904777
SGTC_2269 7935389 174.42 µM 0.357695568866221 0.331826740021996 no 1110 0.360285574768913 1623 97605
SGTC_1748 st037455 53.6035 µM 0.353237157783862 0.333496105036761 no 1111 0.361955326612094 1738 580690
SGTC_2618 avocadyne 43.43 µM 0.352691256404384 0.333700734757059 no 1112 0.362159957523847 1772 3015189
SGTC_2255 7941087 197.44 µM 0.351881576912655 0.334004332120511 no 1113 0.362463538099474 1824 935561
SGTC_1665 st014639 11.4 µM 0.351320893527935 0.334214629614445 no 1114 0.362673810978388 1759 981133 YIL048W NEO1
SGTC_1804 st050076 49.1 µM 0.35130400687792 0.33422096415758 no 1115 0.362680144615268 1741 3895976
SGTC_833 3852-0053 558 µM 0.350882041581997 0.33437926768048 no 1116 0.362838422361606 1758 3123681
SGTC_251 melphalan 456.522 µM 0.349337517795647 0.334958958707006 no 1117 0.363417967680745 1796 460612 A DNA alkylator.
SGTC_1125 tnp00248 1.32998 µM 0.347824421258464 0.335527235998359 no 1118 0.363986023992221 1892 24207736
SGTC_2343 7990716 14.84 µM 0.347006669312687 0.335834517846824 no 1119 0.364293154175535 1745 6456862
SGTC_2477 5967686 25.23 µM 0.34595440015743 0.336230084354752 no 1120 0.364688492239618 1654 776118
SGTC_3312 9133330 71.43 µM 0.345626965971404 0.336353209656155 no 1121 0.364811538814441 1792 17617324
SGTC_2473 5854593 8.94 µM 0.345291957471036 0.336479201299134 no 1122 0.364937446155571 1688 2872951
SGTC_13 0199-0087 65 µM 0.345065883417526 0.336564234717677 no 1123 0.365022420538806 1758 4589825
SGTC_1973 st070275 50.2 µM 0.345012384417983 0.336584358563264 no 1124 0.365042530161034 1764 17118334
SGTC_3115 9123671 49.47 µM 0.344828759033427 0.33665343348724 no 1125 0.365111555529357 1757 3286988
SGTC_1826 st055655 41.6 µM 0.344725506975574 0.3366922765515 no 1126 0.365150370227504 1715 676168
SGTC_1915 st067105 30.6 µM 0.343393287582093 0.337193608980958 no 1127 0.365651304306977 1657 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1480 1070-0044 41.2 µM 0.343221700666562 0.337258200535368 no 1128 0.365715840189175 1788 3124987
SGTC_1439 4092-1168 46 µM 0.343112680867435 0.337299242044336 no 1129 0.365756845808543 1747 2886240
SGTC_2237 6667747 47.222 µM 0.342869594101196 0.337390761270422 no 1130 0.365848283561639 1673 729940 YDL015C TSC13
SGTC_1637 st007924 17.4 µM 0.342791112418426 0.337420310729088 no 1131 0.365877806289364 1684 683336
SGTC_1621 st003705 32.4 µM 0.342566444057435 0.337504907073707 no 1132 0.365962324959315 1834 24207032
SGTC_578 3460-0051 92 µM 0.341008277115988 0.338091843117853 no 1133 0.366548675292613 1853 2876744
SGTC_2139 5578692 56.4705 µM 0.34079381410948 0.338172658690358 no 1134 0.366629403816067 1828 650991 YMR113W FOL3
SGTC_2842 9000675 19.48 µM 0.340128643188396 0.338423360846405 no 1135 0.36687982608237 1617 2989072
SGTC_1927 st060202 13.8 µM 0.339989236081475 0.338475912308429 no 1136 0.36693231698672 1844 688887
SGTC_2080 5212524 12.4 µM 0.339054686235822 0.338828285151052 no 1137 0.367284266880553 1859 260183
SGTC_2651 TUB2.036 5 µM 0.338665124668988 0.338975211365683 no 1138 0.367431008061712 1807 15992207 YFL037W TUB2
SGTC_547 1120-0019 610 nM 0.336210586568356 0.339901522411042 no 1139 0.368356035099651 1714 3676939
SGTC_464 bw-b 70c 158 µM 0.333961156883155 0.34075127803841 no 1140 0.369204434909657 1813 5353454
SGTC_1519 esterone 74 µM 0.332769677937376 0.341201704927848 no 1141 0.369654074247291 1633 698 A steroid.
SGTC_2280 7785178 200 µM 0.332439255901825 0.341326657845402 no 1142 0.369778800247125 1737 2954328
SGTC_1554 st069299 38.7 µM 0.328911793901816 0.342661690287024 no 1143 0.37111117980626 1795 24207999
SGTC_2904 7225135 42.03 µM 0.328244777163158 0.342914356669609 no 1144 0.371363297179635 1825 4446116
SGTC_2729 fluphenazine 10.66 µM 0.32797782277874 0.343015498863049 no 1145 0.371464215426338 1679 3372 An atypical antipsychotic.
SGTC_1063 disulfiram 1.84 µM 0.327535102815372 0.34318325893719 no 1146 0.371631598785144 1748 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_220 paclitaxel 373.376 µM 0.327303550156477 0.343271013603214 no 1147 0.371719153776886 1789 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_405 ebelactone b 50 µM 0.326646943731586 0.34351990263462 no 1148 0.371967466724155 1730 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_658 3253-0951 102 µM 0.325858926410763 0.343818693026684 no 1149 0.372265546461355 1763 1184878
SGTC_1291 0993-0025 5.79 µM 0.324969947630552 0.344155881827614 no 1150 0.372601908314848 1829 4353356
SGTC_576 1073-0113 22.7 µM 0.324117617134324 0.344479286362079 no 1151 0.372924494862277 1837 5439563
SGTC_2228 7354201 200 µM 0.323379223829977 0.344759551019034 no 1152 0.373204030989803 1827 753451
SGTC_1696 st025591 34.7925 µM 0.321216079105185 0.345581084514573 no 1153 0.37402332396013 1743 2787147
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.321147226712936 0.345607245706176 no 1154 0.374049411234148 1740 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1267 0828-0272 9.49 µM 0.321000270333588 0.345663085796661 no 1155 0.374105093020257 1851 745334
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.3191769235651 0.346356195177007 no 1156 0.374796177423409 1687 23665772 A membrane-active detergent.
SGTC_1737 st035557 69.7 µM 0.319176389385734 0.346356398310324 no 1157 0.374796379946978 1683 5716916
SGTC_2012 4023501 200 µM 0.31908634783029 0.346390639200746 no 1158 0.37483051791997 1700 3477460
SGTC_3285 9112818 20.8695 µM 0.318429747558557 0.346640368273211 no 1159 0.375079488197773 1760 17017947 YPR165W RHO1
SGTC_1609 st001574 46.4 µM 0.316673432454511 0.347308686436627 no 1160 0.375745704934011 1716 3960012
SGTC_807 1315-0151 48 µM 0.315651990559798 0.347697587116069 no 1161 0.376133335419136 1901 4011080
SGTC_3317 9138495 8.753 µM 0.314313856318802 0.348207306820328 no 1162 0.376641337652426 1757 17020139
SGTC_271 rotenone 740 µM 0.312915173985834 0.348740383624345 no 1163 0.377172554462382 1838 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1317 1273-0028 910 nM 0.312549591883572 0.348879766441259 no 1164 0.377311440201459 1755 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1491 4138-0063 26.5 µM 0.311661890260618 0.349218298809564 no 1165 0.377648746736585 1864 23883227
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.311201843758002 0.349393788584983 no 1166 0.377823590733815 1795 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1111 tnp00062 510.699 nM 0.309980003866438 0.349860029024665 no 1167 0.378288081258519 1878 676306
SGTC_1964 st076914 61 µM 0.306597002466618 0.351152124353676 no 1168 0.37957506775748 1787 24208661
SGTC_1610 st001799 48.1 µM 0.306400058279304 0.351227397940028 no 1169 0.379650031994962 1705 621897
SGTC_1241 0364-0022 50.8 µM 0.305972280202642 0.351390918122077 no 1170 0.379812875724003 1815 4563895
SGTC_2184 6075246 200 µM 0.305522855870069 0.351562742320238 no 1171 0.37998398256702 1824 2267320
SGTC_3119 9125183 49.47 µM 0.30537992301061 0.351617394861516 no 1172 0.380038405530963 1889 22695334
SGTC_712 r015-0009 80.6 µM 0.304280709627303 0.352037798144448 no 1173 0.380457020160089 1842 6813872 YLR060W FRS1
SGTC_2391 6285546 200 µM 0.303768316702474 0.35223382892828 no 1174 0.380652203196503 1729 846083
SGTC_2694 st077685 81.9 µM 0.302462398134728 0.352733623446248 no 1175 0.38114979690507 1723 2838096
SGTC_3060 1327-0027 12.5 µM 0.301976072353489 0.352919812603933 no 1176 0.381335151729101 1884 16000455 YPR107C YTH1
SGTC_2884 9058502 51.95 µM 0.296801661723397 0.354903001965559 no 1177 0.383308968368973 1742 6471554
SGTC_957 1187-1561 14.1 µM 0.295411172701859 0.355436606374814 no 1178 0.38383989968602 1826 1538454
SGTC_26 0302-0163 425.158 µM 0.295375289814326 0.355450380299372 no 1179 0.383853603763265 1829 3100915
SGTC_441 propafenone 146 µM 0.29533382549728 0.355466296934052 no 1180 0.383869439631942 1778 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_3067 9117431 49.47 µM 0.295079826271955 0.355563803446854 no 1181 0.383966450124798 1768 17150885
SGTC_542 3381-0244 89.3 µM 0.294568639413423 0.355760069106174 no 1182 0.384161710902824 1900 1112843
SGTC_2723 salbutamol 83.58 µM 0.294375898400447 0.355834080238663 no 1183 0.384235340854339 1870 9884233 β2-adrenoceptor agonist
SGTC_2685 mycophenolic acid 18.85 µM 0.293360988486637 0.356223887772182 no 1184 0.384623120490107 1860 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3032 9089427 49.47 µM 0.292704084614474 0.356476272166427 no 1185 0.384874173750921 1775 17173707
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.292354153525082 0.356610742388682 no 1186 0.385007928924638 1742 6708514
SGTC_27 0485-0001 32.618 µM 0.292232639580685 0.356657441487261 no 1187 0.385054378753286 1899 2054479
SGTC_1437 4092-1038 11.6 µM 0.291552732617931 0.356918776579134 no 1188 0.385314309892928 1790 3977136
SGTC_2779 methotrexate 400 µM 0.289496565945937 0.357709511317448 no 1189 0.386100703711994 1879 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2032 5185112 25.99 µM 0.288434921343194 0.35811802469251 no 1190 0.386506919826627 1844 5718189
SGTC_2322 7413319 38.22 µM 0.287719842148974 0.358393273752544 no 1191 0.386780600077143 1804 1840400
SGTC_323 4013-0906 34.3 µM 0.285762015823561 0.359147258591985 no 1192 0.387530201222739 1927 2910086
SGTC_1430 4049-0248 69.1 µM 0.285703283779556 0.359169885574926 no 1193 0.38755269469995 1919 22774488
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.285641500745263 0.359193688509078 no 1194 0.387576357067276 1836 1377
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.285417860936962 0.359279854007419 no 1195 0.387662012668949 1769 6708760
SGTC_145 3737-0113 38.366 µM 0.284833371476797 0.359505083953283 no 1196 0.387885902004875 1920 6849351
SGTC_448 monastrol 171 µM 0.284411184410198 0.359667801894257 no 1197 0.388047644420213 1860 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2057 5236571 38.335 µM 0.283863438734391 0.359878950134179 no 1198 0.388257518038814 1917 54684039 YBR257W POP4
SGTC_370 0180-0345 38.7 µM 0.283365890132399 0.360070785180987 no 1199 0.388448186490116 1766 3989527
SGTC_2108 5365811 200 µM 0.283022583382493 0.36020317122747 no 1200 0.388579762714463 1876 780283
SGTC_1402 3909-7673 35.9 µM 0.282814857485239 0.360283282689372 no 1201 0.388659382241152 1772 5328014
SGTC_264 promethazine 12.5 mM 0.282471129445955 0.360415858140418 no 1202 0.388791140476468 1941 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_663 1486-0733 13.9 µM 0.281357366081487 0.360845550425663 no 1203 0.389218157370065 1815 722445 YPR165W RHO1
SGTC_278 4092-0821 23.9 µM 0.279628155304232 0.36151303165977 no 1204 0.389881401831866 1881 877900
SGTC_615 k087-0205 167 µM 0.278406958986832 0.361984671778964 no 1205 0.390349989053375 1769 9642773
SGTC_137 0438-0332 85.389 µM 0.27801146661293 0.362137460481306 no 1206 0.390501778263454 1863 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_774 k060-0086 136 µM 0.277259640394159 0.362427970516445 no 1207 0.390790373719084 1970 5911235
SGTC_759 3486-0358 89.3 µM 0.277016843271735 0.362521805674897 no 1208 0.390883586502134 1963 875103
SGTC_2759 disulfiram 3.38 µM 0.276327802604691 0.362788148025963 no 1209 0.391148151763034 1782 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3129 9127257 49.47 µM 0.27491626255361 0.363333973095255 no 1210 0.391690286335763 1701 837894
SGTC_2010 4012422 159 µM 0.274813630017759 0.363373670666243 no 1211 0.391729712950652 1854 952393
SGTC_666 0272-0154 136 µM 0.273686774108706 0.363809627330089 no 1212 0.392162671278797 1848 6870312
SGTC_3176 9106582 49.47 µM 0.273141199157144 0.364020762114456 no 1213 0.392372339010326 1934 17018027
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.270608971930246 0.365001260990546 no 1214 0.393345897309911 1908 17037758
SGTC_1925 st057770 10.1 µM 0.269878494224819 0.36528427232527 no 1215 0.393626866303367 1700 5989122
SGTC_1392 3455-1037 33.9 µM 0.269555722743556 0.36540934810616 no 1216 0.393751033918521 1912 981132
SGTC_1931 st074438 57.1 µM 0.268917665068157 0.365656641184042 no 1217 0.393996521394591 1892 2787313
SGTC_2361 9034121 116 µM 0.268614770243565 0.365774054190241 no 1218 0.394113072453986 1817 6496917
SGTC_1298 1079-1278 263 µM 0.266901639627816 0.366438362067762 no 1219 0.394772447093693 1836 2840950
SGTC_3286 9117135 37.221 µM 0.266801320128625 0.366477275811385 no 1220 0.394811068886398 1758 3438150
SGTC_1946 st076057 65.1 µM 0.265974450884185 0.36679806907844 no 1221 0.395129442876669 1832 953009
SGTC_3121 9125696 49.47 µM 0.264990596691397 0.367179887645722 no 1222 0.395508352854781 1994 1235365
SGTC_996 3970-0799 1.8 µM 0.264674887563141 0.367302437329886 no 1223 0.395629962292795 1953 6615648 YGL040C HEM2
SGTC_1590 st077108 57.8 µM 0.262740595329649 0.368053571598068 no 1224 0.396375262576868 1956 5489485
SGTC_2903 5923464 63.88 µM 0.261854629836438 0.368397782977695 no 1225 0.396716759756662 1975 2876576
SGTC_2587 piperic acid 92.2 µM 0.261130067980027 0.368679365077395 no 1226 0.396996102488748 1801 5370536
SGTC_2044 5102272 200 µM 0.26109811292752 0.368691785201257 no 1227 0.397008423443965 1842 592666
SGTC_2027 5150920 200 µM 0.260637461348181 0.368870844098982 no 1228 0.397186048947533 1925 786715
SGTC_867 0518-0118 155 µM 0.260054272364098 0.369097575079592 no 1229 0.397410954997693 1998 6848158
SGTC_175 3793-3120 23.7 µM 0.259320673859911 0.36938284663827 no 1230 0.397693914712209 1830 5322297
SGTC_3215 9129942 49.47 µM 0.256324415652324 0.370548735123927 no 1231 0.398850172946481 2006 17682944
SGTC_550 4123-0385 25.7 µM 0.255848675237396 0.370733962512269 no 1232 0.399033843495316 1844 5731123
SGTC_2031 5180455 200 µM 0.255647606502839 0.370812256729241 no 1233 0.399111477436815 1847 29949
SGTC_3015 9080845 49.47 µM 0.254740853848831 0.371165403840917 no 1234 0.399461630048318 1954 5296973
SGTC_1075 aripiprazole 15.2 µM 0.254443934759879 0.37128106660302 no 1235 0.399576306247042 1835 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1390 3413-2614 145 µM 0.253748068220107 0.37155218209983 no 1236 0.3998450980055 1836 3421432
SGTC_5 0352-0601 109.883 µM 0.253326430760446 0.371716486640323 no 1237 0.400007986638781 1881 762456
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.252662003442696 0.371975449446134 no 1238 0.400264706102018 1831 688667
SGTC_3174 9107204 49.47 µM 0.251588216468375 0.372394083977205 no 1239 0.400679683806121 1940 3938802
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.251202488258962 0.372544503677125 no 1240 0.400828780440732 2022 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2979 9012552 45.46 µM 0.247503118514024 0.373988105018051 no 1241 0.402259439169486 2029 17100905
SGTC_1670 st016595 4.04 µM 0.244390552373531 0.375204090110728 no 1242 0.403464179049142 1990 597879
SGTC_1795 st049545 62.3 µM 0.244357300966244 0.375217087148066 no 1243 0.403477054201104 2031 5291882
SGTC_109 0132-0036 33.701 µM 0.244181751805993 0.37528570671185 no 1244 0.403545029662886 1998 67274 A color developer.
SGTC_2792 7535235 81.82 µM 0.241717773183801 0.376249254942293 no 1245 0.40449942843456 1804 1281891
SGTC_3245 9134821 49.47 µM 0.241344238566595 0.376395394596213 no 1246 0.404644163296677 1816 17014901
SGTC_2661 dactinomycin 12.96 µM 0.24007047398992 0.376893868453863 no 1247 0.405137811643814 1914 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1568 digitonin 820 nM 0.239916110885343 0.376954290731002 no 1248 0.405197645444174 2044 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_160 3453-0671 289.699 µM 0.238658403549287 0.37744670669947 no 1249 0.4056852369499 1868 5322268
SGTC_995 3931-2021 34.6 µM 0.237688561844118 0.377826554022722 no 1250 0.40606132789655 1897 730143
SGTC_2945 9067681 61.76 µM 0.237444780643513 0.377922051744964 no 1251 0.406155876460524 1930 16456930
SGTC_2735 sertaconazole 140 nM 0.237109531647415 0.378053392823036 no 1252 0.40628590900557 1981 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_447 ml7 120 µM 0.236621621104144 0.378244567560259 no 1253 0.406475172630274 2008 4216 Selective myosin light chain kinase inhibitor.
SGTC_1092 toremifene 6.32 µM 0.236165283942771 0.378423398091265 no 1254 0.406652208515193 1996 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1949 st076024 69.1 µM 0.236012418081625 0.378483309366466 no 1255 0.406711517054972 1766 2921930
SGTC_2372 9071633 200 µM 0.235582104772148 0.378651973683587 no 1256 0.40687848049314 2031 21321366
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.23379943044476 0.379350951292693 no 1257 0.407570345880914 1900 364106
SGTC_3118 9124250 49.47 µM 0.23181664366577 0.380128855416056 no 1258 0.408340214687351 1868 1504786
SGTC_390 dec-rvkr-cmk 16.7 µM 0.230796679835933 0.380529205664499 no 1259 0.408736380358237 1921 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1222 0366-0074 1.18 µM 0.230722256404459 0.380558422930649 no 1260 0.408765290929964 2006 286520
SGTC_2829 7992743 58.44 µM 0.230413353258275 0.380679699887679 no 1261 0.408885292939852 2078 16462845
SGTC_2427 5545055 42.75 µM 0.229907617148599 0.380878279783554 no 1262 0.40908177861784 1906 5372858
SGTC_2939 9044578 71.43 µM 0.22951863513969 0.381031036932282 no 1263 0.40923291921243 1865 2653634
SGTC_2971 9092186 9.93 µM 0.229070049252977 0.381207224144353 no 1264 0.409407235897137 1743 25236400
SGTC_1049 3226-0134 66 µM 0.228548768207268 0.381411994141002 no 1265 0.409609823806926 1974 5702385
SGTC_2087 5276107 200 µM 0.227813330594831 0.381700945724836 no 1266 0.409895681429269 1896 144405
SGTC_294 k038-0071 157 µM 0.22777348812694 0.381716601614117 no 1267 0.409911169187555 1890 24152826
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.227602010219564 0.381783985168662 no 1268 0.409977828519328 1982 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_724 3910-0327 137 µM 0.22746547158847 0.381837641629292 no 1269 0.410030907619164 1854 2885483
SGTC_649 1123-0311 367 µM 0.226375367227215 0.382266108257512 no 1270 0.410454742393608 2001 693629 YIL048W NEO1
SGTC_1391 3442-0225 151 µM 0.224630429649794 0.382952257716153 no 1271 0.41113339517525 1903 5227075
SGTC_750 4073-0104 132 µM 0.224139401894704 0.383145407429352 no 1272 0.411324417024583 1984 22330957
SGTC_2217 6934799 96.0675 µM 0.223248287879338 0.383496008466978 no 1273 0.41167113591928 2006 675606
SGTC_1506 4226-2149 212 µM 0.222247326926263 0.383889941602035 no 1274 0.412060676834352 1925 991114
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.221479700853344 0.384192125971287 no 1275 0.412359470264157 2046 5024745
SGTC_1292 0kpi-0043 232 µM 0.221421458364121 0.384215056637879 no 1276 0.41238214284792 1890 3333905
SGTC_2152 5568786 200 µM 0.221348801889812 0.384243662806645 no 1277 0.412410426904698 1935 5399883
SGTC_1496 4469-0713 57.4 µM 0.218753699661094 0.385265813856881 no 1278 0.413420957801985 1995 746691
SGTC_320 4092-0846 5.34 µM 0.218615597312759 0.385320231608061 no 1279 0.413474750893217 1986 1359356
SGTC_737 1950-0117 57.9 µM 0.217748363295885 0.385662007455596 no 1280 0.413812589607426 2034 5393513
SGTC_2369 9071472 200 µM 0.217611036952983 0.385716135746587 no 1281 0.413866092161813 1943 17296037
SGTC_313 3474-0040 5.03 µM 0.216343582751487 0.386215818022498 no 1282 0.414359969621147 1894 1043375 YIL048W NEO1
SGTC_2333 9017922 200 µM 0.215809606984707 0.386426389675438 no 1283 0.414568079741715 2015 3163164
SGTC_3281 9140613 49.47 µM 0.215070544954822 0.386717891625028 no 1284 0.414856159127416 1835 16013766
SGTC_2772 vinpocetine 57.06 µM 0.214844337387714 0.386807125536145 no 1285 0.414944341856662 1992 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_114 0364-0001 490.298 µM 0.211865020473894 0.387982957309019 no 1286 0.416106170354093 1875 4003655
SGTC_2953 9074162 66.49 µM 0.211226250729478 0.388235191462184 no 1287 0.416355363859461 2076 16451992
SGTC_2820 7989630 71.43 µM 0.211058419986504 0.388301471439426 no 1288 0.416420842691277 2073 2984098
SGTC_2737 bleomycin 30.5 nM 0.210594813620167 0.388484576483283 no 1289 0.416601729843931 1982 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1703 st026983 48.3 µM 0.210196440084643 0.388641937098707 no 1290 0.416757178951755 2057 1104023
SGTC_1638 st008370 60.6 µM 0.209977221506616 0.388728537922899 no 1291 0.416842725660844 1987 24207134
SGTC_2671 danthron 100 µM 0.20872816165014 0.389222076014331 no 1292 0.417330227255928 1943 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_72 0744-0168 198.391 µM 0.206370737820734 0.390154045885298 no 1293 0.418250663340079 1941 677577
SGTC_368 fentichlor 4.58 µM 0.203924614582985 0.391121749454013 no 1294 0.419206204788779 1903 7329 A pesticide.
SGTC_1461 k072-0203 53.8 µM 0.203254501095031 0.391386969010126 no 1295 0.419468058024519 2049 5418714
SGTC_121 0557-0495 61.343 µM 0.202798382840826 0.391567521776139 no 1296 0.419646310989984 1903 3104427
SGTC_73 0327-0325 16.231 µM 0.201750535959997 0.39198239660766 no 1297 0.420055876428926 2082 53298
SGTC_505 gw-5074 63.9 µM 0.201077804565153 0.392248816454163 no 1298 0.420318868464454 2024 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_788 1182-0090 188 µM 0.199978389620844 0.392684323224872 no 1299 0.420748741160041 2046 5715185
SGTC_1913 st060213 96.1 µM 0.19928735169332 0.392958130091417 no 1300 0.421018986311743 2057 688959
SGTC_506 n9-isopropylolomoucine 153 µM 0.198945424738272 0.393093629876756 no 1301 0.421152717927843 2097 6610355
SGTC_492 tmb-8 126 µM 0.197964684298769 0.393482352291364 no 1302 0.421536347357938 2063 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_465 cgp-37157 41 µM 0.197400325478574 0.39370608749092 no 1303 0.421757137468195 2075 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_977 1348-1378 135 µM 0.196881433174266 0.393911828851576 no 1304 0.421960161742215 2018 X977
SGTC_2879 9041815 71.43 µM 0.195340115164596 0.394523137530275 no 1305 0.422563347275759 2076 4942971
SGTC_2486 5283202 22.39 µM 0.194780205849785 0.39474526996145 no 1306 0.422782509466763 1882 1377751
SGTC_306 1672-3436 11.6 µM 0.194067189650511 0.395028193911391 no 1307 0.423061636026843 2006 6797378
SGTC_3076 9116187 49.47 µM 0.193107374423492 0.395409134800862 no 1308 0.423437438702198 2069 27241210
SGTC_1324 1418-0026 34.4 µM 0.191154523061308 0.396184509856537 no 1309 0.424202265946265 1971 1372513
SGTC_2705 st078069 42.8 µM 0.190019770964263 0.396635249455316 no 1310 0.4246468188979 1963 1530061
SGTC_1450 4112-4260 37.6 µM 0.189792653597945 0.396725480301193 no 1311 0.424735806423321 2067 1633175
SGTC_1573 oleylamine 1.06 µM 0.189051991519569 0.397019774340395 no 1312 0.425026034046703 1936 5356789 An amine of the fatty acid oleic acid.
SGTC_1838 st055369 84.5 µM 0.188433583220772 0.397265537104217 no 1313 0.425268387799817 2076 676036
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.185880787727728 0.398280478956594 no 1314 0.426269124400196 1923 2374 Ca(2+)-ATPase inhibitor.
SGTC_3307 9126885 69.2785 µM 0.183490711688708 0.39923135102667 no 1315 0.427206503026072 1913 24824909
SGTC_930 2810-3379 265 µM 0.183314779662592 0.399301367839268 no 1316 0.427275519200366 2099 1015764
SGTC_3029 9088683 49.47 µM 0.183044135966973 0.399409083994741 no 1317 0.42738169405281 2001 25236615
SGTC_2507 purpurin 79.67 µM 0.182903496175518 0.399465061637579 no 1318 0.427436869811818 1877 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1144 3486-0183 12.5 µM 0.181547279671998 0.400004970694117 no 1319 0.42796901292655 1985 6744069
SGTC_1484 3473-2379 286 µM 0.18134150330065 0.400086906887766 no 1320 0.428049765548749 2091 671917
SGTC_763 3453-1109 128 µM 0.180932952537936 0.400249596976656 no 1321 0.428210101656462 2094 1560353
SGTC_1169 aniline yellow 25.8 µM 0.178771904836017 0.401110440868292 no 1322 0.429058403280025 2028 6051 A DNA damaging agent.
SGTC_955 1216-0110 33 µM 0.177038635641785 0.401801228395705 no 1323 0.429739021011801 1981 3619719
SGTC_1194 1488-0194 225 µM 0.176754613354937 0.401914453670263 no 1324 0.429850570459037 1994 1391452
SGTC_891 0929-0073 133 µM 0.176490014299175 0.402019943295861 no 1325 0.429954496492169 2054 5603632
SGTC_1896 st058441 89 µM 0.175536472517795 0.402400157875279 no 1326 0.430329057368062 1948 688759
SGTC_127 0180-0333 59.125 µM 0.175088575900421 0.402578783757266 no 1327 0.430505017361487 2116 771601
SGTC_1216 1165-0504 9.65 µM 0.172960130708358 0.403427907480193 no 1328 0.43134138316497 2109 6304004
SGTC_3220 9131269 49.47 µM 0.171713080694347 0.403925618535142 no 1329 0.431831550828689 2100 17722206
SGTC_555 4296-0685 37 µM 0.171463672768851 0.404025178612594 no 1330 0.431929596165259 2081 2908540 YHR072W ERG7
SGTC_2443 5493264 126.67 µM 0.169940499669287 0.404633342235385 no 1331 0.432528465104691 2068 5340055
SGTC_2091 4-phenylthiadiazole 200 µM 0.169335479559238 0.404874975152307 no 1332 0.432766385138651 2009 270010
SGTC_257 daunorubicin 18.5 µM 0.169064764603425 0.40498310503724 no 1333 0.432872849848459 2096 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_608 k048-0125 159 µM 0.168815253061332 0.40508277220775 no 1334 0.432970980157155 2103 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2365 9042475 200 µM 0.168015087114038 0.405402439306026 no 1335 0.433285705001284 1985 6464479
SGTC_814 3342-0569 96 µM 0.16567580497248 0.4063373460755 no 1336 0.434206043860878 2086 4346283
SGTC_1438 4092-1045 4 µM 0.165018781834776 0.406600025255156 no 1337 0.434464599477113 2050 1351342
SGTC_79 0052-0007 94.094 µM 0.163940088827999 0.40703138000456 no 1338 0.434889153850512 2086 2801472
SGTC_1477 0139-0234 16 µM 0.163830936402862 0.407075034876475 no 1339 0.434932118494165 2115 620880
SGTC_681 1642-0006 26.6 µM 0.162105408668134 0.407765302602756 no 1340 0.435611423516286 2116 4446530
SGTC_604 1000-0114 314 µM 0.162103371628722 0.407766117655059 no 1341 0.435612225569787 2107 1572745
SGTC_1274 0865-0114 173 µM 0.162099701023674 0.407767586324311 no 1342 0.435613670815751 2028 870624
SGTC_2215 7188065 200 µM 0.162022186928425 0.407798601287171 no 1343 0.435644191034865 2111 940217
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.159608963581504 0.408764469014691 no 1344 0.436594558796306 2116 5355888
SGTC_1048 3161-0300 24.5 µM 0.156967433003617 0.409822349712041 no 1345 0.437635257293882 2096 2165101
SGTC_2924 9010168 62.78 µM 0.156627942298403 0.409958356808045 no 1346 0.437769039784053 2019 2993929
SGTC_1992 st073643 23.3 µM 0.156339919185899 0.410073753402204 no 1347 0.437882546111273 2099 3161292
SGTC_2944 9067346 25.62 µM 0.155727523792842 0.410319135773297 no 1348 0.438123900496476 2048 6473075
SGTC_2287 7945887 168.79 µM 0.154428279477099 0.410839849666524 no 1349 0.438636028652889 2131 1245853
SGTC_2107 5363541 170.161 µM 0.154411265582182 0.410846669575936 no 1350 0.438642735769155 2137 244052
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.154404702494368 0.410849300354316 no 1351 0.438645323035233 2104 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2257 7960413 200 µM 0.153800331945785 0.41109157620442 no 1352 0.438883586048172 2061 2974689 YIL048W NEO1
SGTC_1008 4106-0037 6 µM 0.152315852376927 0.411686807801916 no 1353 0.439468911206178 2049 2905394
SGTC_1124 fisetin 1.16336 µM 0.152132479409589 0.411760348973432 no 1354 0.439541223743333 1964 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.151805864819505 0.411891344438271 no 1355 0.439670028146607 2123 88881 An O-methylated flavonoid and antioxidant.
SGTC_683 panaxydol 45 µM 0.151805231337988 0.411891598518542 no 1356 0.439670277973894 2103 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1689 st020265 53.493 µM 0.150898613268265 0.412255267714922 no 1357 0.440027847206403 2139 5758320 YPR016C TIF6
SGTC_1843 st055809 45.5 µM 0.150087055571935 0.412580869535924 no 1358 0.440347966230253 2040 16413835
SGTC_2278 7948257 134.34 µM 0.145416332100615 0.414455954750861 no 1359 0.442191085284609 2179 1247028
SGTC_1018 4259-0013 28.1 µM 0.144183375884362 0.414951258436586 no 1360 0.442677833948128 2040 6801262
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.144179111766332 0.414952971654946 no 1361 0.44267951749486 2124 2333 A French combination drug.
SGTC_2567 aureobasidin a 60 nM 0.143753319426089 0.415124052744936 no 1362 0.442847632800485 2043 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_3211 9128781 49.47 µM 0.142999656302334 0.41542691000459 no 1363 0.443145226317256 1896 17194361
SGTC_1311 1190-0148 100 µM 0.142641973600975 0.415570661317325 no 1364 0.443286473136808 2132 1961333
SGTC_1993 st073995 70.8 µM 0.141788111504968 0.415913870886905 no 1365 0.443623687418341 2072 3098394
SGTC_765 1319-0117 244 µM 0.14175798053839 0.415925983191505 no 1366 0.44363558773609 2172 3487746 YGL099W LSG1
SGTC_3078 9116413 49.47 µM 0.141701941609906 0.415948510413414 no 1367 0.443657720618099 2129 17177322
SGTC_490 phenamil 164 µM 0.141154827799334 0.416168460492395 no 1368 0.44387381544063 2154 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2673 kobusone 100 µM 0.141145173380458 0.416172341986973 no 1369 0.443877628819088 2131 6710676 An epoxy ketone and protein crosslinker.
SGTC_805 3852-0218 479 µM 0.140674972972849 0.416361392806508 no 1370 0.444063358564675 1980 6615355
SGTC_2469 5655019 90.81 µM 0.140634242380571 0.416377770036788 no 1371 0.444079447778046 2142 2788239
SGTC_1746 st038117 42 µM 0.140354757790331 0.416490150993469 no 1372 0.444189850994624 2040 2898218
SGTC_1728 st035614 33.7865 µM 0.138484863326291 0.417242212102723 no 1373 0.444928615832822 2031 15945546
SGTC_1413 3910-0535 34.4 µM 0.137198858607751 0.417759611972884 no 1374 0.445436806539425 2151 2876951
SGTC_348 k064-0012 10.7 µM 0.136779276792728 0.417928453695653 no 1375 0.445602632199177 2135 5066323
SGTC_232 clozapine 119 µM 0.133996379233364 0.419048686427979 no 1376 0.446702718784321 2149 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1615 st002656 86.5 µM 0.133090350911142 0.419413542874266 no 1377 0.447060963058672 2186 1584458
SGTC_2188 6126565 140.678 µM 0.133046155505073 0.419431342082893 no 1378 0.44707843906259 2147 874518
SGTC_124 0136-0217 7.121 µM 0.133015094316436 0.419443851730067 no 1379 0.44709072151953 2208 3976905
SGTC_2241 6772625 37.8075 µM 0.132989980699555 0.419453966099455 no 1380 0.447100652178462 2209 2285411
SGTC_1260 0700-1617 7.75 µM 0.132840089256674 0.419514335150105 no 1381 0.447159924330285 2080 2853078
SGTC_1100 amiodarone 5.07 µM 0.132582254684154 0.419618182923404 no 1382 0.447261883610906 2192 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1431 4049-0260 9.09 µM 0.131867341927016 0.419906156881171 no 1383 0.447544610185895 2104 3854841
SGTC_1189 1431-2119 7.28 µM 0.131000620381512 0.420255338432457 no 1384 0.447887408320617 2173 3107275
SGTC_247 mechlorethamine 29.705 µM 0.130584163414924 0.420423141409922 no 1385 0.448052135602527 2079 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2218 6965428 192.983 µM 0.130532807016568 0.420443835442418 no 1386 0.448072449966875 2141 675684
SGTC_2140 5586273 200 µM 0.129456688820532 0.420877507170558 no 1387 0.448498146906779 2185 854421
SGTC_179 1273-0063 6.77 µM 0.128044392364319 0.421446803160309 no 1388 0.449056921067163 2088 3108139
SGTC_1213 1315-0166 115 µM 0.126694857147074 0.421990953607722 no 1389 0.449590958219453 1953 768401
SGTC_705 1124-0212 310 µM 0.125601531112084 0.422431906400533 no 1390 0.45002367545185 2200 9554485
SGTC_668 1682-0499 62.6 µM 0.12544703364489 0.422494225117668 no 1391 0.450084827355699 2061 682214
SGTC_2430 5571206 200 µM 0.124786651674431 0.422760621285033 no 1392 0.45034622760306 2190 1731771
SGTC_2778 tioconazole 65.09 nM 0.124050813598943 0.423057497833783 no 1393 0.450637521153311 2147 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3053 9095903 49.47 µM 0.122153015524112 0.423823372656672 no 1394 0.451388917945062 2208 17174018
SGTC_474 dl-dihydrosphingosine 5 µM 0.122087660913356 0.423849752286974 no 1395 0.451414796969426 2164 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_545 4218-0007 221 µM 0.121573678364745 0.424057227264626 no 1396 0.45161833022563 2111 2840508
SGTC_861 0443-0273 110 µM 0.120796973876208 0.424370792901971 no 1397 0.4519259235253 2131 6149169
SGTC_3320 9137005 35.139 µM 0.120015347346087 0.42468639396277 no 1398 0.452235495204925 2030 4908713
SGTC_2072 5231554 129 µM 0.11940829269729 0.424931540629728 no 1399 0.452475945840192 2216 789545
SGTC_224 benfluorex 43.875 µM 0.118477464276921 0.425307493105763 no 1400 0.452844675110981 2202 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1161 k007-0610 110 µM 0.118072664706917 0.425471008898702 no 1401 0.453005041161892 2203 5843850
SGTC_2617 dihydrotanshinone i 20.83 µM 0.115599366368529 0.426470356907975 no 1402 0.453985032552587 2135 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2051 5263410 176 µM 0.115565079977886 0.426484213821484 no 1403 0.453998619782067 2228 227584
SGTC_999 SEC7.066 22.7 µM 0.1153578270297 0.426567977447546 no 1404 0.454080752447461 2116 740511 YDR170C SEC7
SGTC_2813 7971799 71.43 µM 0.115053485209363 0.426690986642702 no 1405 0.454201364204825 2110 2234054
SGTC_1716 st033144 30.6155 µM 0.114515914071216 0.426908280120973 no 1406 0.454414415890615 2207 674617
SGTC_229 benomyl 22.8748 µM 0.113621230139472 0.427269972538899 no 1407 0.454769028559876 2116 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1504 k297-0033 30 µM 0.11289930303495 0.427561869425201 no 1408 0.455055194448235 2055 4388117
SGTC_3199 9111318 49.47 µM 0.112494826385635 0.427725428868284 no 1409 0.455215535826011 2161 8548020
SGTC_1799 st045822 46.1415 µM 0.111579200074328 0.428095729283708 no 1410 0.455578532477794 2206 3674992
SGTC_2499 avocadenofuran 51.48 µM 0.110970933655405 0.428341761294529 no 1411 0.455819697962487 2194 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1322 1348-1070 12 µM 0.110224630451225 0.428643664562878 no 1412 0.456115614505925 2193 6758089
SGTC_328 k915-0120 63.5 µM 0.109718811792706 0.428848307974773 no 1413 0.456316190418057 2204 6624543
SGTC_1079 idarubicin 2.36 µM 0.109562097111224 0.42891171526747 no 1414 0.456378335879398 2227 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1962 st076595 64.5 µM 0.108066178335024 0.429517061198628 no 1415 0.456971598387693 2184 279619
SGTC_1062 mesoridazine 14.2 µM 0.107671059387025 0.429676979729909 no 1416 0.457128313642441 2205 4078 A neuroleptic.
SGTC_196 k015-0023 18.111 µM 0.106975078135926 0.429958695863452 no 1417 0.457404375523741 2072 5211998
SGTC_692 k241-0027 77.8 µM 0.106944472390985 0.429971085137711 no 1418 0.457416515805622 2200 3600480
SGTC_1798 st045719 60.953 µM 0.105005066740969 0.430756301017104 no 1419 0.4581858941356 2218 3980186
SGTC_1371 2421-0008 32.7 µM 0.103091157374434 0.431531462578102 no 1420 0.458945311511778 2121 2827552
SGTC_1352 1496-0991 99 µM 0.10268657609491 0.4316953578418 no 1421 0.459105864021938 2179 3000039
SGTC_3043 9092303 49.47 µM 0.100719588972883 0.432492348393849 no 1422 0.459886530348718 2147 25236084
SGTC_1186 1319-0216 26 µM 0.100541726676483 0.432564428839151 no 1423 0.459957128773756 2239 4565136
SGTC_503 tyrphostin 8 294 µM 0.100050812312068 0.432763388352858 no 1424 0.460151992697506 2224 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2706 st078239 82.5 µM 0.0999417808704062 0.43280757931727 no 1425 0.460195273022035 2249 15434492
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.0989829280815119 0.433196243066152 no 1426 0.460575912474154 2248 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_401 neomycin 50 µM 0.0987401573553678 0.433294658616584 no 1427 0.460672291841419 2133 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1187 1391-0724 117 µM 0.0982871158069753 0.43347832581006 no 1428 0.460852154370111 2123 6997986
SGTC_729 4092-0585 94.1 µM 0.0951219932080374 0.434761894142496 no 1429 0.462108964613801 2152 2169061
SGTC_2417 cerulenin 830 nM 0.0949434216810823 0.434834331792067 no 1430 0.462179883380422 2270 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1505 k297-0037 20.6 µM 0.0935562944014554 0.435397095132108 no 1431 0.462730814643355 2095 4089396
SGTC_2128 5255449 168.493 µM 0.09312075370352 0.435573822864992 no 1432 0.462903815001017 2208 736008
SGTC_1183 1254-0324 198 µM 0.091822376640575 0.436100736727455 no 1433 0.463419582588616 2202 5799357
SGTC_3256 9138902 49.47 µM 0.0917890406174182 0.436114266816336 no 1434 0.463432825811107 2248 17228773
SGTC_1733 st037357 54.9 µM 0.0904551504870988 0.436655713868469 no 1435 0.463962766258663 2249 1272339 YGL099W LSG1
SGTC_3242 9133940 49.47 µM 0.08894298004368 0.437269671217215 no 1436 0.464563612875458 2222 17248444
SGTC_2344 7990960 76.95 µM 0.0888956747700308 0.437288880108393 no 1437 0.46458241048907 2152 140813
SGTC_3085 9117376 49.47 µM 0.0877556780415226 0.437751834474842 no 1438 0.465035432798367 2155 16480349
SGTC_1565 sinapyl alcohol 95.1 µM 0.0860744028095487 0.438434758195912 no 1439 0.465703635844672 2150 5280507 A phenol propionate derived from cinnamic acid.
SGTC_3134 9127454 49.47 µM 0.0844951878959146 0.439076392685825 no 1440 0.466331364331964 2266 24262820
SGTC_954 1189-0853 2.85 µM 0.0843034594594949 0.439154302818455 no 1441 0.466407580972572 2269 2828194
SGTC_2105 5350118 200 µM 0.0841431847554426 0.439219433325521 no 1442 0.466471294947498 2177 2133313
SGTC_873 0591-4978 488 µM 0.083788914370823 0.439363403300531 no 1443 0.466612131037626 2248 3305145
SGTC_2082 5219693 150 µM 0.0830290694275667 0.43967221949547 no 1444 0.466914212675031 2248 2834649
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.0823622382697672 0.439943263279144 no 1445 0.467179331743473 2251 6708784 An antioxidant flavonoid
SGTC_1140 3229-1848 2.98 µM 0.0811430021629772 0.440438913251739 no 1446 0.46766411381818 2242 2849525
SGTC_1357 1503-1303 39.5 µM 0.0807632663399604 0.440593304460484 no 1447 0.467815110908046 2247 292895
SGTC_2318 6029776 164 µM 0.0806200726154286 0.44065152583912 no 1448 0.467872051263455 2220 818325
SGTC_159 3970-0959 50 µM 0.0797686826339275 0.440997720381051 no 1449 0.46821061628254 2223 6615653
SGTC_2101 5377231 179.231 µM 0.079028674784291 0.441298661053817 no 1450 0.468504907603041 2206 2844213
SGTC_90 0870-0863 4.608 µM 0.0784119241489025 0.441549502340244 no 1451 0.468750194318599 2256 1738164
SGTC_944 3370-0224 231 µM 0.0783066053056772 0.441592339363453 no 1452 0.468792081662661 2206 4580514
SGTC_2174 5790901 200 µM 0.0781237155175991 0.441666728948356 no 1453 0.468864821294647 2195 786020
SGTC_176 1486-1328 72.834 µM 0.0760608660633056 0.442505925405777 no 1454 0.469685337135048 2209 22310231
SGTC_747 3448-8087 38.7 µM 0.073421282791184 0.443580121232627 no 1455 0.470735441040907 2213 5168703
SGTC_2855 9016525 58.44 µM 0.0728753754264761 0.443802333850328 no 1456 0.470952644695763 2262 43811474
SGTC_2130 NSC 7 2.4545 µM 0.0721826038444667 0.444084353255419 no 1457 0.471228294588829 2260 21448
SGTC_3237 9133362 49.47 µM 0.0719536029931578 0.444177583122678 no 1458 0.471319415769822 2276 43845137
SGTC_2049 5262831 67.185 µM 0.0715536253560146 0.444340427749119 no 1459 0.471478573513337 2216 763417
SGTC_935 2996-0153 430 µM 0.0705430188977602 0.444751922132806 no 1460 0.47188073084155 2297 23738523
SGTC_2893 9048488 25.97 µM 0.0703640777378908 0.444824788841304 no 1461 0.47195194108311 2196 6467338
SGTC_3114 9122766 49.47 µM 0.0701418659337787 0.444915278402949 no 1462 0.472040372272126 2159 17176985
SGTC_1191 1487-1166 10.6 µM 0.069908403087779 0.445010352729939 no 1463 0.472133282399303 2226 3955771
SGTC_646 4092-0839 27.3 µM 0.069802782209064 0.445053366326482 no 1464 0.472175316349562 2248 877796
SGTC_2784 7567673 72.73 µM 0.0697813369737929 0.445062099874773 no 1465 0.472183850949567 2280 3471247
SGTC_2716 st080858 38.6235 µM 0.0697212112101513 0.445086586167539 no 1466 0.472207779379184 2272 5296050
SGTC_3026 9090633 49.47 µM 0.0679366336125875 0.445813452631825 no 1467 0.472918038349629 2253 25236842
SGTC_2440 5628896 157.78 µM 0.0677537589361978 0.445887948639101 no 1468 0.472990827074849 2248 5522048
SGTC_2403 6032726 181.2 µM 0.0676437567127606 0.445932760172889 no 1469 0.473034611163739 2224 2881040
SGTC_3290 9121031 71.43 µM 0.0668834206417945 0.446242516634879 no 1470 0.47333725594594 2235 17014854
SGTC_1199 1638-0010 4.46 µM 0.0661031140105268 0.446560443097414 no 1471 0.473647865827204 2247 3111136
SGTC_1625 st003711 30.1 µM 0.0660247655759958 0.446592367116938 no 1472 0.473679054196072 2269 24207034 YER133W GLC7
SGTC_1026 k007-1105 30.6 µM 0.0652145973879061 0.446922500225242 no 1473 0.474001569417709 2291 7066794
SGTC_3294 9122953 26.2835 µM 0.0646378986565136 0.447157519960024 no 1474 0.474231154512689 2295 16459826
SGTC_1816 st051957 91.6 µM 0.0645677894812384 0.447186092539469 no 1475 0.474259065722032 2286 674121
SGTC_407 eburnamonine 100 µM 0.0645613915287903 0.447188700000775 no 1476 0.474261612821333 2259 3195
SGTC_2532 xanthone 78.9 µM 0.0636763305150005 0.447549425217266 no 1477 0.474613976001272 2269 7020 An insecticide.
SGTC_189 3970-0742 2.116 µM 0.0631288823201433 0.447772570971542 no 1478 0.474831937698172 2309 2891807
SGTC_741 4582-0002 126 µM 0.0626147074781018 0.447982169205391 no 1479 0.475036658762698 2257 2912688
SGTC_721 1187-1332 279 µM 0.0617713594816665 0.448325983005654 no 1480 0.475372455870098 2284 25730
SGTC_1456 k015-0012 13 µM 0.0617283112812963 0.448343533821476 no 1481 0.4753895969064 2313 2989616
SGTC_927 2425-1185 123 µM 0.0615838685392772 0.44840242408251 no 1482 0.475447111798611 2301 730375
SGTC_2414 st077232 92.9 µM 0.0597302631156348 0.449158251740797 no 1483 0.47618523413879 2090 729801
SGTC_2424 5537928 59.2 µM 0.0596373107080182 0.449196158971855 no 1484 0.476222250795968 2248 5382802
SGTC_1440 4100-1550 40 µM 0.0583548460614913 0.449719212337457 no 1485 0.476732990533458 2282 742806
SGTC_2529 gangaleoidin 93.61 µM 0.0581185696940479 0.449815587241284 no 1486 0.476827091458389 2284 4565183
SGTC_2395 5646831 180.19 µM 0.0574731860588183 0.450078848212968 no 1487 0.47708413260896 2268 6808628
SGTC_256 clotrimazole 625 nM 0.0564977612285286 0.450476779242332 no 1488 0.477472639479582 2297 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1264 0783-0040 158 µM 0.055049092882197 0.451067864869475 no 1489 0.478049676297474 2265 2855798
SGTC_1168 k815-0004 80.5 µM 0.0548232531190217 0.451160021815653 no 1490 0.478139637474279 2286 642433
SGTC_2485 5633444 17.78 µM 0.0546460245359041 0.451232344161279 no 1491 0.478210235618236 2239 5724239
SGTC_1287 0971-0001 34.6 µM 0.0542607628177046 0.451389564965173 no 1492 0.478363705105228 2290 4665869
SGTC_2708 st078559 56 µM 0.0535729422762279 0.451670275432253 no 1493 0.478637707239775 2308 17250902
SGTC_2157 5649910 96.377 µM 0.053080067673853 0.451871440242341 no 1494 0.478834056376439 2291 2858091
SGTC_3160 9100216 49.47 µM 0.049985910599516 0.453134588405618 no 1495 0.480066807999481 2323 17191039
SGTC_3033 9090887 49.47 µM 0.0492454986438684 0.453436922479656 no 1496 0.480361826277279 2288 19325384
SGTC_1497 4476-2978 41.3 µM 0.0488012109237432 0.453618352448347 no 1497 0.480538858574268 2278 1528379
SGTC_3240 9133527 49.47 µM 0.0481374484511625 0.453889425464064 no 1498 0.480803350618937 2300 17617455
SGTC_205 1486-1330 71.903 µM 0.0478309362593668 0.454014608801712 no 1499 0.48092549059766 2306 4118834
SGTC_2746 daunorubicin 9.88 µM 0.0470158329862563 0.454347529168384 no 1500 0.481250304292449 2316 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2094 5332512 191.667 µM 0.046639927140458 0.454501074782247 no 1501 0.481400104691903 2315 755774
SGTC_2259 7964009 200 µM 0.0456151896157985 0.454919682019769 no 1502 0.481808481105973 2276 313134
SGTC_2408 sulbentine 18.36 µM 0.0451285223182064 0.455118504104163 no 1503 0.482002433527039 2193 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_456 gingerol 170 µM 0.0450590558658521 0.45514688470776 no 1504 0.482030118469662 2290 442793 A herb.
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.044384867195622 0.455422337179625 no 1505 0.482298811994943 2320 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1416 3966-0321 25.3 µM 0.0441549582916602 0.455516275697047 no 1506 0.482390442543238 2302 582530 YLR208W SEC13
SGTC_1363 1636-0063 10.4 µM 0.0440696080599529 0.455551149595766 no 1507 0.48242445924675 2324 6072185
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.043993207771645 0.455582366859723 no 1508 0.482454909020196 2311 641818 YHR062C RPP1
SGTC_2173 5763948 167 µM 0.0436724199947616 0.455713444181986 no 1509 0.482582761944961 2333 2867177
SGTC_838 0109-0203 71.4 µM 0.0431915069349789 0.455909959436498 no 1510 0.482774437628262 2321 759422
SGTC_1044 1222-0021 1.78 µM 0.0420800109684023 0.45636419065274 no 1511 0.483217457495478 2263 4306703
SGTC_1765 st044815 90.4 µM 0.041257294221736 0.456700444225506 no 1512 0.48354538916762 2256 645695
SGTC_1695 st026914 34.495 µM 0.0407913596607655 0.456890890680713 no 1513 0.483731113809578 2311 3289191
SGTC_2292 7671323 168.05 µM 0.0407567249680208 0.456905047687897 no 1514 0.483744919571915 2274 937504
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.039458377279451 0.457435789473107 no 1515 0.48426246888681 2334 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_940 3232-1287 54.8 µM 0.0372795388715164 0.458326630567921 no 1516 0.485131059883023 2351 1585493 YIL048W NEO1
SGTC_17 0960-0276 49.807 µM 0.0367425475464891 0.458546217472915 no 1517 0.485345141747467 2338 6821114
SGTC_3028 9087778 49.47 µM 0.0354929039048233 0.459057271571742 no 1518 0.485843352337774 2339 17217395
SGTC_2201 6605497 169.863 µM 0.0351511667102714 0.459197040188539 no 1519 0.485979600731394 2317 670741
SGTC_1734 st037168 69.4 µM 0.0346543437723509 0.45940024700577 no 1520 0.486177683715839 2160 708907
SGTC_438 sphingosine 6.67 µM 0.0337263860293642 0.459779821737463 no 1521 0.486547668964592 2332 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_907 3448-6986 75.5 µM 0.0302008957210797 0.461222230601122 no 1522 0.487953417088236 2344 590582
SGTC_2465 5809242 33.21 µM 0.0295244894747318 0.461499032416314 no 1523 0.488223143838159 2358 2731748
SGTC_1879 gemcitabine 100 µM 0.0294501696894264 0.461529447011797 no 1524 0.488252780255509 2343 60750 A nucleoside analog which inhibits DNA replication.
SGTC_510 ag-490 170 µM 0.0276497296975427 0.462266326593587 no 1525 0.488970759122873 2348 5328779
SGTC_2718 lomofungin 53.02 µM 0.0252314146844857 0.463256291905991 no 1526 0.489935189816447 2336 5351222 A RNA synthesis inhibitor.
SGTC_943 3253-1379 105 µM 0.0230380855697018 0.464154353613863 no 1527 0.490809946555928 2359 668464
SGTC_2593 nobiletin 86.24 µM 0.0222348786702195 0.464483273750482 no 1528 0.491130297653313 2343 72344 An anti-infammatory.
SGTC_21 0849-0113 22.993 µM 0.0221209746094486 0.464529920413827 no 1529 0.491175727625063 2352 1560156
SGTC_2889 9059656 51.95 µM 0.0220347989499711 0.464565211902566 no 1530 0.491210098361421 2345 3949838
SGTC_1659 st012954 42.1 µM 0.0215090870539668 0.464780512545304 no 1531 0.491419777359986 2346 24207262
SGTC_36 0335-0881 14.2 µM 0.0214014719242932 0.464824586640406 no 1532 0.491462699704866 2351 23828853
SGTC_3268 9137683 49.47 µM 0.0212974116470818 0.464867205245576 no 1533 0.491504204289192 2364 1953228
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.0212889714841733 0.46487066199026 no 1534 0.491507570663786 2348 115019
SGTC_2377 9073351 62.6 µM 0.0202907184712506 0.465279524124793 no 1535 0.491905729925621 2361 7337946 YHR072W ERG7
SGTC_1887 st057648 70.8 µM 0.018105278481481 0.466174758902619 no 1536 0.492777433511668 2372 688672
SGTC_1984 st072354 53.1 µM 0.0180301236387918 0.466205548098162 no 1537 0.492807411062624 2356 5762938
SGTC_3166 9102297 49.47 µM 0.017304778912664 0.466502715374155 no 1538 0.493096736577013 2351 25237072
SGTC_2984 9022109 38.96 µM 0.0140941897245112 0.467818287189667 no 1539 0.494377417962254 2383 6459207
SGTC_1999 st074831 12.5 µM 0.0126175453194348 0.4684234762657 no 1540 0.494966461256167 2367 17112523
SGTC_1007 4101-0031 70 µM 0.0122143143766538 0.468588749488565 no 1541 0.495127314728232 2386 1146276
SGTC_2765 myclobutanil 7.74 µM 0.00971267138379443 0.469614223711035 no 1542 0.496125265650602 2369 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_210 3551-0445 56.827 µM 0.00885601487240566 0.469965431274019 no 1543 0.496467007413106 2359 2865180 YOR207C RET1
SGTC_18 0111-0177 500 nM 0.00862074664482903 0.4700618894148 no 1544 0.496560862272691 2389 721752
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.00800947157728788 0.470312515629245 no 1545 0.496804717307951 2389 23847180
SGTC_960 1222-0186 7.7 µM 0.00796731989934583 0.470329798488773 no 1546 0.496821532857924 2384 3126296
SGTC_2731 amoxapine 43.43 µM 0.00776708342538451 0.470411899396129 no 1547 0.496901413181284 2389 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2023 5144124 124 µM 0.0072666101225829 0.470617108823371 no 1548 0.497101067499287 2388 2830192
SGTC_3232 9132874 49.47 µM 0.00642100197949401 0.470963851838263 no 1549 0.497438408429941 2395 3784940
SGTC_395 anisomycin 6.25 µM 0.00314170026801318 0.472308740762179 no 1550 0.498746644992569 2395 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_431 k089-0097 107 µM 0.00179934641912878 0.472859351391731 no 1551 0.49928216502367 2403 5499420
SGTC_561 1550-0330 72.9 µM 0.00118397473947261 0.473111783749158 no 1552 0.499527662527851 2402 6812934
SGTC_2248 tofa 1.1 µM 0.000355153383865796 0.473451792603284 no 1553 0.499858314302127 2403 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2531 methyl deoxycholate 70.07 µM -0.000146273800028837 0.473657503372294 no 1554 0.499941645196862 2406 16667744 Haematoxylin.
SGTC_535 2293-4129 48.2 µM -0.000440497796073674 0.47377821219702 no 1555 0.499824266810406 2406 396118 YIL048W NEO1
SGTC_2034 5197015 53.07 µM -0.000570827346605176 0.473831682184722 no 1556 0.499772272848997 2408 780676
SGTC_2988 9073640 71.4286 µM -0.00076200886642429 0.473910118614594 no 1557 0.499696002474562 2409 9102229
SGTC_2605 digitonin 300 nM -0.00136529662682063 0.474157637324815 no 1558 0.499455325619487 2407 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_752 1896-0090 130 µM -0.00212110010293192 0.474467744706585 no 1559 0.499153804122492 2413 772567
SGTC_3128 9127691 49.47 µM -0.00270056885056941 0.474705512152965 no 1560 0.498922630213929 2417 41316314
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.00281959063863002 0.474754350256156 no 1561 0.498875147571273 2412 688669
SGTC_37 0566-0070 1.56 µM -0.00285613810366916 0.474769346820761 no 1562 0.498860567300939 2421 1626686
SGTC_703 3875-0075 71.8 µM -0.00324547103367102 0.474929104477485 no 1563 0.498705246657808 2411 2850814
SGTC_1820 st053765 18.6 µM -0.00462424378072556 0.47549489801525 no 1564 0.49815520021574 2419 3690829
SGTC_976 1348-1067 47.6 µM -0.00482420170760904 0.475576956931424 no 1565 0.498075429434716 2416 5310671 YGL099W LSG1
SGTC_1107 amlodipine 47 µM -0.0049686421395909 0.475636233172086 no 1566 0.498017806730204 2422 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1229 0139-0193 12.2 µM -0.00524899208228812 0.475751286225923 no 1567 0.497905964744669 2413 3090752
SGTC_2790 5423970 71.43 µM -0.00565024446097421 0.475915960049662 no 1568 0.497745890583759 2428 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_785 1270-0111 65.3 µM -0.00575411909225858 0.4759585908303 no 1569 0.4977044512752 2420 6741994
SGTC_35 0133-0054 64.071 µM -0.00681473805719238 0.47639389097095 no 1570 0.497281333901914 2432 99677
SGTC_1658 st012944 20 µM -0.0072402190191438 0.476568525177304 no 1571 0.497111595749316 2429 24207260
SGTC_60 0986-0278 202 µM -0.00782695394255157 0.47680935175899 no 1572 0.496877529026651 2410 3110598
SGTC_100 0086-0128 49.5915 µM -0.00892583782607572 0.477260413675707 no 1573 0.49643915318569 2423 93297
SGTC_302 1094-0063 18.9 µM -0.00925764746087655 0.47739661825027 no 1574 0.496306785764775 2431 5440289
SGTC_2020 4017018 200 µM -0.00975121743435167 0.477599228724861 no 1575 0.49610988872949 2420 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_3194 9111903 49.47 µM -0.00983516982911543 0.477633691760624 no 1576 0.49607639817571 2443 17087251
SGTC_443 clozapine 122 µM -0.00998506105422294 0.477695223555739 no 1577 0.496016603164927 2420 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3170 9103054 49.47 µM -0.0102950684426939 0.477822486267282 no 1578 0.495892934468952 2429 16432970
SGTC_2475 5812728 15.03 µM -0.0113843126695267 0.478269655307717 no 1579 0.495458414443225 2421 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.0118898926151969 0.478477221119327 no 1580 0.495256730885596 2428 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1214 0358-0031 63.7 µM -0.0119150098154677 0.478487533136833 no 1581 0.495246711282198 2440 4301366
SGTC_2983 9022671 12.99 µM -0.0141888380196417 0.479421125782354 no 1582 0.494339662530972 2443 6405161
SGTC_84 0443-0269 128.823 µM -0.0144893785676648 0.479544530842781 no 1583 0.494219776525358 2427 6150058
SGTC_1701 st028638 40.4 µM -0.0146239295383792 0.47959977950044 no 1584 0.494166104141099 2434 3490878
SGTC_853 0419-0306 21 µM -0.0147313386868818 0.47964388359796 no 1585 0.494123258705888 2438 762713
SGTC_1742 st038235 28.8875 µM -0.0150892384136293 0.47979084535636 no 1586 0.493980493243961 2460 564103 YBR002C RER2
SGTC_531 3788-1495 174 µM -0.0152089698978284 0.479840010438012 no 1587 0.493932732773365 2438 2896655
SGTC_2552 juarezic acid 87.02 µM -0.0153515510757561 0.47989855864025 no 1588 0.493875857753307 2426 1549512
SGTC_938 3126-1755 342 µM -0.0153775622048897 0.479909239654011 no 1589 0.493865482038903 2432 1777771
SGTC_3273 9137859 49.47 µM -0.0161572990577757 0.480229431574108 no 1590 0.49355445071402 2432 2377234
SGTC_2730 imipramine 71.33 µM -0.0165605422982194 0.480395024798735 no 1591 0.49339360146143 2443 3696 A tricyclic antidepressant.
SGTC_584 0986-0246 15.4 µM -0.0168738431883847 0.480523685224611 no 1592 0.493268629954138 2429 53315 YDR232W HEM1
SGTC_725 1497-0963 19 µM -0.0172645316355318 0.48068412853544 no 1593 0.493112790519219 2440 3549977
SGTC_1909 st060837 51.5 µM -0.0175935476685787 0.480819247376899 no 1594 0.492981552048061 2450 678937
SGTC_2654 protoveratrine a 100 µM -0.0178466534432999 0.480923193231525 no 1595 0.492880593305247 2431 5702278 A heart drug and vasodilator.
SGTC_2854 9024559 71.43 µM -0.0180312008707028 0.480998984260542 no 1596 0.492806981379121 2449 3163529
SGTC_811 0416-0114 265 µM -0.0191689235582243 0.481466246008303 no 1597 0.492353174227044 2472 6612453
SGTC_3202 9113761 49.47 µM -0.0203131331348625 0.481936197596094 no 1598 0.491896789611252 2461 4798415
SGTC_472 calcifediol 10 µM -0.0203520294335368 0.481952173590969 no 1599 0.491881275440379 2479 5283731 A vitamin D metabolite.
SGTC_1256 0570-0116 285 µM -0.0205380316124802 0.482028571231006 no 1600 0.491807086814075 2447 410638
SGTC_2927 9011802 47.9 µM -0.0205641484821999 0.482039298401317 no 1601 0.491796669890524 2470 43912568
SGTC_2624 nerol 100 µM -0.0219688772424068 0.482616291736904 no 1602 0.49123639095312 2439 637566 A natural product oil.
SGTC_2816 7982706 58.44 µM -0.0229080179602404 0.483002064837008 no 1603 0.490861822333801 2479 2981853
SGTC_1244 0416-0015 52.5 µM -0.0231534407282173 0.483102880377395 no 1604 0.490763938778199 2456 96201
SGTC_3161 9100388 49.47 µM -0.023353473093632 0.483185051104164 no 1605 0.490684158982631 2446 25236368
SGTC_2330 7979373 200 µM -0.0237500825472148 0.483347975282713 no 1606 0.490525978580156 2454 1863007
SGTC_710 3448-4187 58 µM -0.0243440934273137 0.483591995674015 no 1607 0.490289071035819 2459 3946412
SGTC_1488 4013-0813 75.9 µM -0.0244387646733749 0.483630887307107 no 1608 0.490251313906359 2447 2910057
SGTC_2268 7933382 153.85 µM -0.0246454879522379 0.483715811267108 no 1609 0.490168868083181 2436 935025 YOR257W CDC31
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.0246671376762025 0.48372470522985 no 1610 0.490160233717893 2452 165506
SGTC_1591 genipin 88.4 µM -0.0247520801733523 0.483759600690805 no 1611 0.490126356907959 2515 442424 A DNA cross-linking agent.
SGTC_1898 st060199 18.6 µM -0.0252768805326217 0.483975198118448 no 1612 0.489917057350424 2437 688866
SGTC_1972 st070201 17.4 µM -0.0261649990398766 0.484340063816998 no 1613 0.489562866519327 2462 2829099
SGTC_430 0958-0115 16.4 µM -0.0264190724435238 0.484444447211093 no 1614 0.489461540924342 2487 6833180
SGTC_81 0411-0046 9.971 µM -0.0267809708685211 0.484593131223643 no 1615 0.489317215410784 2446 12925265
SGTC_2575 plumbagin 510 nM -0.0269706815362088 0.484671073683569 no 1616 0.489241559133092 2450 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3274 9138298 49.47 µM -0.028011983563125 0.48509890205079 no 1617 0.488826296698439 2442 17015756
SGTC_676 falcarinol 140 µM -0.029187720585821 0.485581984846535 no 1618 0.488357437307793 2451 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1933 st074711 15.9 µM -0.0302966262429453 0.486037627602761 no 1619 0.48791524360368 2453 17250958
SGTC_470 aa-861 153 µM -0.0309028150557945 0.486286714734023 no 1620 0.487673522453464 2466 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1855 st056195 39.6 µM -0.0311572206601563 0.486391253337189 no 1621 0.487572078151977 2477 4028379
SGTC_1743 st037606 46.3785 µM -0.0320658228585267 0.486764617494406 no 1622 0.487209779397123 2489 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1160 4092-0570 10.5 µM -0.0335223685173955 0.487363167456231 no 1623 0.486629014178519 2464 4994975
SGTC_333 3486-0131 40.1 µM -0.033536042854311 0.487368786897897 no 1624 0.486623561972934 2513 6744690
SGTC_2834 9001755 58.44 µM -0.0336581327580324 0.487418959612998 no 1625 0.486574882629866 2569 2989575
SGTC_1851 st056236 18.9 µM -0.0340623116633732 0.487585057917395 no 1626 0.486413730984621 2473 5393171
SGTC_3172 9105863 49.47 µM -0.03469386472986 0.487844600487066 no 1627 0.486161926610109 2459 2348785
SGTC_400 oxethazaine 37.5 µM -0.0356528092355463 0.488238697401074 no 1628 0.485779599690515 2503 4621 A local anesthetic.
SGTC_2299 7976368 114.88 µM -0.0380193848364635 0.489211336056889 no 1629 0.484836113168265 2496 2979718
SGTC_1029 k015-0030 64.7 µM -0.0382984651717937 0.489326039595881 no 1630 0.484724857252794 2575 2208316
SGTC_1091 telmisartan 47.6 µM -0.038884507554481 0.489566909071512 no 1631 0.484491234204095 2548 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_311 1315-0136 58 µM -0.0413846936643149 0.490594553070247 no 1632 0.483494607514941 2518 6759207
SGTC_538 2922-0838 53.3 µM -0.0427507563354189 0.491156068525342 no 1633 0.482950109410655 2477 777039
SGTC_1878 temozolomide 1 mM -0.0436544505499972 0.491527538686691 no 1634 0.482589923885874 2472 5394 DNA alkylating agent.
SGTC_515 4092-1064 102 µM -0.0437263927529568 0.491557111378991 no 1635 0.482561250479097 2502 717353
SGTC_1709 st033179 39.1045 µM -0.0441365132701534 0.491725697143361 no 1636 0.482397793875381 2467 573381
SGTC_280 3448-3607 3.04 µM -0.0448933499465602 0.492036809283756 no 1637 0.482096158738045 2479 626179
SGTC_354 2783-3500 4.88 µM -0.045669267175356 0.492355769876158 no 1638 0.481786929740785 2503 6740761
SGTC_3165 9101544 49.47 µM -0.0459726439705709 0.492480481995888 no 1639 0.481666026898771 2513 5002184
SGTC_3188 9110789 49.47 µM -0.0463452889806916 0.492633669895006 no 1640 0.48151752134051 2522 849217
SGTC_2085 5307070 144.047 µM -0.0466092670845516 0.492742187372784 no 1641 0.481412322996903 2474 2840351
SGTC_1305 1181-0477 144 µM -0.046788927749611 0.492816043511464 no 1642 0.481340726872779 2520 6252086
SGTC_1002 4049-0206 172 µM -0.0470911916486446 0.492940300783038 no 1643 0.481220273798495 2507 4662749
SGTC_868 0527-0199 213 µM -0.047320118186308 0.49303441035101 no 1644 0.48112904702404 2545 2849450
SGTC_766 1391-0721 126 µM -0.0486637351502095 0.493586766417765 no 1645 0.480593638387157 2499 1020919 YIL115C NUP159
SGTC_734 2023-0417 80 µM -0.0487611161832554 0.493626799898321 no 1646 0.48055483504134 2542 3935732
SGTC_1651 st011928 86.1 µM -0.0491182638356509 0.493773624350199 no 1647 0.480412524269081 2558 720198
SGTC_791 1348-1292 225 µM -0.0495777836301438 0.493962535529255 no 1648 0.480229425475374 2591 5437054
SGTC_1605 st000082 49.1 µM -0.0499653584747592 0.494121870788002 no 1649 0.480074996878486 2612 1114022
SGTC_1846 st056244 14.8 µM -0.0499797142425886 0.494127772582339 no 1650 0.480069276902309 2561 5393182
SGTC_870 0573-2213 57.6 µM -0.0502707868226149 0.494247435597162 no 1651 0.479953301531857 2493 3916321
SGTC_352 k048-0007 5.11 µM -0.0507952901412731 0.494463065755948 no 1652 0.479744321978476 2487 6811911
SGTC_2692 st077426 47.7 µM -0.0515007856118392 0.494753106690329 no 1653 0.479463237928085 2501 25238571
SGTC_115 0527-0192 112.043 µM -0.0516144069831338 0.494799818591185 no 1654 0.479417969764737 2542 4233931
SGTC_142 0335-0849 62.6745 µM -0.0522794816923199 0.495073244828359 no 1655 0.479153001096775 2514 3889043 YPR107C YTH1
SGTC_1423 4048-0112 5.59 µM -0.0526670594476496 0.495232587291983 no 1656 0.478998592668084 2513 X1423
SGTC_3334 9142812 21.919 µM -0.0531299194048597 0.495422881059617 no 1657 0.478814196436852 2588 45283678
SGTC_2132 5317594 122.667 µM -0.0533367384736445 0.495507910097504 no 1658 0.47873180438958 2510 794577
SGTC_589 1227-0070 34.1 µM -0.0536686730768966 0.495644378016136 no 1659 0.478599571039723 2567 2841384
SGTC_2874 9043904 71.43 µM -0.05370279508072 0.495658406588258 no 1660 0.478585977932569 2565 4463428
SGTC_670 4204-0025 119 µM -0.0538840424474531 0.495732922868895 no 1661 0.478513775238099 2573 719039
SGTC_76 0433-0009 400.328 µM -0.0545497712503313 0.496006625395896 no 1662 0.478248577932967 2635 2841569
SGTC_3104 9120930 49.47 µM -0.054635243962324 0.496041766116285 no 1663 0.478214530029362 2558 17014836
SGTC_95 0471-0001 561.058 µM -0.0548358673949193 0.496124249309522 no 1664 0.47813461266496 2516 4015405
SGTC_2123 5259487 200 µM -0.0557828074830281 0.496513571125756 no 1665 0.477757415628369 2537 2173474
SGTC_2069 5228469 200 µM -0.0564568963062183 0.496790715820158 no 1666 0.477488916245257 2571 2835210
SGTC_3351 9150312 21.596 µM -0.058086074046203 0.497460541645204 no 1667 0.476840033482437 2505 4904905
SGTC_2261 9010538 184.68 µM -0.0582486470688985 0.497527382909391 no 1668 0.476775285857717 2603 6457250
SGTC_1912 st060209 90.8 µM -0.0594331714613192 0.498014397469907 no 1669 0.47630354637084 2561 688787
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.0596955230354729 0.498122263159903 no 1670 0.476199068739061 2498 66535 A nucleotide analog.
SGTC_2407 paclitaxel 400 µM -0.0604916867666308 0.498449606200938 no 1671 0.475882018362799 2790 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3337 9144342 33.5465 µM -0.0610556308796361 0.498681472696283 no 1672 0.475657452308825 2582 17682949
SGTC_3075 9116269 49.47 µM -0.0614997062813269 0.49886405530271 no 1673 0.475480624159367 2578 17015205 YNL244C SUI1
SGTC_1735 st034310 56.75 µM -0.0633745212850246 0.499634891904523 no 1674 0.474734137763321 2736 871153
SGTC_3083 9117465 49.47 µM -0.0637580755356392 0.499792591808637 no 1675 0.474581430588702 2604 16420915
SGTC_2882 9058044 58.44 µM -0.0638430465466216 0.499827527993744 no 1676 0.47454760098184 2561 18076804
SGTC_1837 st055472 66.5 µM -0.0639571328313224 0.499874435046951 no 1677 0.474502179966042 2648 676091
SGTC_2975 9084847 53.72 µM -0.0640575757647834 0.49991573258068 no 1678 0.47446219103325 2633 27211724
SGTC_693 4161-2696 114 µM -0.0644674824005452 0.49991573258068 no 1679 0.474298999258798 2591 805759
SGTC_3093 9117344 49.47 µM -0.0647826746982691 0.499786139949442 no 1680 0.474173518029027 2657 24824913
SGTC_2176 5809774 33.9695 µM -0.0649024231254051 0.499736904888052 no 1681 0.474125845644487 2553 2870539
SGTC_2247 cerulenin 830 nM -0.0661566172036471 0.499221238185413 no 1682 0.4736265677622 2703 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_389 tpck 16.7 µM -0.0661601060879712 0.499219803718666 no 1683 0.473625178941445 2556 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_9 0092-0002 10.449 µM -0.0662068329989218 0.499200591790057 no 1684 0.473606578383241 2522 759368
SGTC_2920 7982904 15.77 µM -0.0664320003035608 0.499108013512531 no 1685 0.473516946953732 2587 6456808
SGTC_934 2950-0684 338 µM -0.068610307328778 0.498212398642466 no 1686 0.472649907070606 2588 1121253
SGTC_2916 7875993 68.79 µM -0.069744494458012 0.497746078835764 no 1687 0.472198513263633 2535 1299250
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.0703422227954702 0.497500324677553 no 1688 0.471960638393068 2505 4620898
SGTC_2122 5258151 111.688 µM -0.0705536790364121 0.497413385320092 no 1689 0.47187648863156 2567 2173356
SGTC_3039 9090270 49.47 µM -0.0714358909376173 0.497050668924152 no 1690 0.471525422862296 2536 17173750
SGTC_1604 st002052 72.4 µM -0.0717260838548388 0.49693135827812 no 1691 0.471409948852869 2652 6254834 YHR062C RPP1
SGTC_14 0354-0009 295 µM -0.0731830468873896 0.496332343196118 no 1692 0.470830228416917 2524 1713507
SGTC_2704 st078022 71.1 µM -0.0738530385419229 0.496056885842829 no 1693 0.47056366178101 2587 54697681
SGTC_1470 k295-0292 231 µM -0.0738768895450898 0.496047079882613 no 1694 0.470554172529593 2640 5045612
SGTC_1011 4112-3381 17.4 µM -0.0743970970929084 0.495833205436011 no 1695 0.470347209294125 2696 2877139
SGTC_1284 0929-0043 16 µM -0.0747050250724087 0.495706606667903 no 1696 0.470224704709432 2600 1239883
SGTC_1940 st075990 51.1 µM -0.0753447039683353 0.495443616178201 no 1697 0.469970226958367 2779 1084979
SGTC_2349 9023730 187.07 µM -0.0754505170780213 0.495400113537152 no 1698 0.469928133451891 2589 4126287
SGTC_299 1273-0059 1.44 µM -0.0767869081303069 0.494850691788008 no 1699 0.469396532892731 2564 2848077
SGTC_2657 nystatin 74.44 µM -0.0769794767595125 0.494771523082343 no 1700 0.469319935843198 2582 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1991 st073000 8.92 µM -0.0771820256488908 0.494688251520044 no 1701 0.469239370221362 2710 4301969 YIL048W NEO1
SGTC_2061 5245884 80.95 µM -0.0773582856715254 0.494615787981102 no 1702 0.46916926225481 2563 573863
SGTC_2677 mitomycin C 100 µM -0.0775548138737376 0.494534992053134 no 1703 0.469091093684672 2548 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2058 5236698 133 µM -0.0800483085199902 0.493509896593413 no 1704 0.468099417284841 2582 766665
SGTC_2754 granisetron 64.02 µM -0.0802911708735902 0.49341005613187 no 1705 0.468002840083004 2598 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2733 amorolfine 100 µM -0.0803215687964243 0.493397559606277 no 1706 0.467990752107621 2579 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_887 0885-0007 9.62 µM -0.0806081728150805 0.493279737584716 no 1707 0.467876783196379 2687 5719458
SGTC_75 0159-0059 199.013 µM -0.0832468551920878 0.492195012325121 no 1708 0.466827628474892 2573 5377270
SGTC_3313 9133968 57.047 µM -0.0838172545108649 0.491960536488568 no 1709 0.466600864588965 2544 1494643
SGTC_362 0310-0100 9.03 µM -0.0842678838160092 0.491775296847266 no 1710 0.466421723277594 2633 790235
SGTC_1680 diphenhydramine 100 µM -0.0849083437800434 0.49151202680906 no 1711 0.466167129183934 2622 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2281 7943571 200 µM -0.0862327870371073 0.490967607717469 no 1712 0.465640683743036 2598 1244024
SGTC_3304 9125678 46.087 µM -0.0868426323358029 0.490716933322892 no 1713 0.465398299952769 2584 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1834 st055981 52.8 µM -0.0874123279166376 0.490482765614562 no 1714 0.465171885313815 2709 471719 YDL150W RPC53
SGTC_2222 6885208 172.143 µM -0.08751797526465 0.49043934067996 no 1715 0.465129899028196 2580 609514
SGTC_673 1082-0474 110 µM -0.087817964306562 0.490316034801232 no 1716 0.465010679737809 2567 3098046
SGTC_2827 7993847 71.43 µM -0.0892375470184348 0.489732549926063 no 1717 0.464446563094634 2628 2985692
SGTC_1800 st050079 29.0735 µM -0.0900983659891673 0.489378741890164 no 1718 0.464104523845984 2595 3645560
SGTC_274 sirtinol 40.1 µM -0.0901694942481337 0.489349507600564 no 1719 0.464076262807741 2607 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_979 1426-2828 121 µM -0.0920984383227522 0.488556718325765 no 1720 0.463309914609213 2663 747872
SGTC_2098 5376439 882.5 nM -0.0927049135656286 0.488307468314473 no 1721 0.463068996681969 2678 2844116
SGTC_406 estrone 100 µM -0.092963482807231 0.488201202562556 no 1722 0.462966286024217 2599 5870 A steroid.
SGTC_1983 st071813 46.9 µM -0.0930450015208474 0.488167700501246 no 1723 0.462933905110034 2644 11838595
SGTC_1374 2889-5571 141 µM -0.0935088487381685 0.487977073010878 no 1724 0.462749660110612 2623 2853281
SGTC_1058 3448-5425 97.3 µM -0.0936477972297556 0.487919969822203 no 1725 0.462694469860181 2557 7279705
SGTC_25 0118-0223 35.662 µM -0.0939331007291005 0.487802720391689 no 1726 0.462581149748227 2592 5333628
SGTC_1219 1469-0211 33.1 µM -0.0940217683466296 0.487766281418607 no 1727 0.462545932346368 2568 6822282
SGTC_2840 9008771 71.43 µM -0.0941873390614083 0.487698238510452 no 1728 0.462480171013755 2712 2992978
SGTC_45 0kpi-0036 14.9 µM -0.0942727840814629 0.487663124181887 no 1729 0.462446234384398 2642 2795021
SGTC_992 3909-8734 162 µM -0.0948037629067502 0.487444916253115 no 1730 0.462235348984818 2611 4288319
SGTC_1813 st051246 8.6015 µM -0.0949498095373711 0.487384898446811 no 1731 0.462177346455289 2594 5291959
SGTC_1170 0310-0127 64.8 µM -0.0957442834641165 0.487058414733859 no 1732 0.4618618346562 2649 774975
SGTC_1034 k072-0165 12.7 µM -0.0958864380188544 0.486999998184848 no 1733 0.461805382919599 2586 5835461
SGTC_2065 5221596 34.26 µM -0.0977192270083163 0.486246863024324 no 1734 0.461077623840896 2691 788581
SGTC_1623 st003709 20.3 µM -0.0989451078663134 0.485743147588055 no 1735 0.460590926852248 2571 16192618
SGTC_1975 st070967 30.8 µM -0.0997314160417756 0.485420064846679 no 1736 0.460278779239886 2607 261391
SGTC_3180 9109287 49.47 µM -0.0999356192557467 0.48533616223443 no 1737 0.460197718905659 2678 18891271
SGTC_677 0929-0063 136 µM -0.0999642749126909 0.485324388306697 no 1738 0.460186343912715 2584 1539583
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.10051930937117 0.485096340387964 no 1739 0.459966026906881 2623 1273210
SGTC_880 0833-0487 87.2 µM -0.101067816159749 0.484870979292121 no 1740 0.459748313088749 2580 76075
SGTC_2908 7930301 100 µM -0.101601894778744 0.484651550838754 no 1741 0.459536337709296 2583 2223178
SGTC_1077 5-fluorocytosine 377 nM -0.101729532957308 0.484599110840334 no 1742 0.459485679918324 2662 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1708 st033234 31.827 µM -0.102395713391916 0.484325415721137 no 1743 0.459221293003771 2679 674664
SGTC_212 3807-4682 38.772 µM -0.10310626719835 0.484033498284949 no 1744 0.458939315515753 2664 3125501 YBL034C STU1
SGTC_2146 5545642 200 µM -0.103338175195063 0.483938225166374 no 1745 0.458847289181477 2589 825326
SGTC_2180 6301957 200 µM -0.103474297198527 0.483882303555246 no 1746 0.458793273920945 2606 845462
SGTC_231 b-estradiol 524 µM -0.104697875844765 0.483379647612984 no 1747 0.458307773765006 2586 450 A steroid.
SGTC_1673 st016611 27.3 µM -0.105683044325143 0.482974951641119 no 1748 0.457916916835837 2785 5226799
SGTC_71 0417-1750 47.813 µM -0.106568382902542 0.482611279606595 no 1749 0.457565701247698 2617 6811472
SGTC_904 1141-0088 396 µM -0.106908578119518 0.482471540869454 no 1750 0.457430753920847 2626 1378119
SGTC_1015 4130-4525 82 µM -0.107731238114791 0.482133633620584 no 1751 0.457104444640471 2616 1363237
SGTC_588 3970-1144 52.9 µM -0.107946130902984 0.482045368602064 no 1752 0.457019211859063 2724 1888707
SGTC_1418 3966-3099 2.4 µM -0.108944516782487 0.481635303407796 no 1753 0.456623248734943 2607 740335
SGTC_279 1273-0055 2.93 µM -0.108950314219741 0.481632922293386 no 1754 0.456620949577644 2629 2847562
SGTC_3350 9150499 3.57 µM -0.109023961531171 0.481602674041266 no 1755 0.456591742530928 2600 4910996 YPR165W RHO1
SGTC_3140 9094243 49.47 µM -0.109278759692519 0.48149802475241 no 1756 0.456490696500284 2587 19291112
SGTC_2112 5488546 200 µM -0.110276596695045 0.481088211008641 no 1757 0.45609500858994 2592 600757
SGTC_3126 9127922 49.47 µM -0.110361772792416 0.481053229927011 no 1758 0.456061234391459 2842 45595682
SGTC_2553 4-methylesculetin 85.09 µM -0.111593707737429 0.480547301420197 no 1759 0.455572780678664 2601 5319502
SGTC_2366 9070441 60.58 µM -0.112373750045 0.480226971400675 no 1760 0.455263533953169 2620 6837235
SGTC_1790 st045711 43.5 µM -0.112720320243797 0.480084653924581 no 1761 0.455126145349127 2612 585119
SGTC_2073 5212005 126 µM -0.11340614301207 0.479803031423449 no 1762 0.454854284856672 2592 691789
SGTC_1025 k007-0731 70 µM -0.114090234902056 0.479522129723999 no 1763 0.454583131548703 2606 6256118
SGTC_2480 5767542 37.17 µM -0.114443952309003 0.479376890320437 no 1764 0.454442936972714 2651 2867358
SGTC_2450 5739737 12.93 µM -0.116068265420007 0.47870996886846 no 1765 0.453799219657963 2681 2262825
SGTC_3096 9117468 49.47 µM -0.1169638136296 0.478342294005585 no 1766 0.453444364572723 2619 41316311
SGTC_2111 5486399 200 µM -0.117579781037041 0.47808941407608 no 1767 0.453200313097734 2596 689674
SGTC_1633 st005664 67.9 µM -0.117973613420728 0.477927734317456 no 1768 0.45304428264752 2612 2063822
SGTC_2982 9019404 25.97 µM -0.118205447118983 0.47783256147325 no 1769 0.45295243702121 2649 22333232
SGTC_244 nsc-207895 1.295 µM -0.118502455797593 0.477710634710721 no 1770 0.452834774681623 2592 42640
SGTC_1410 3909-8106 77.9 µM -0.120954814664521 0.476703983371559 no 1771 0.451863412507191 2693 1039210
SGTC_2861 9024595 19.48 µM -0.122575713882619 0.476038713180437 no 1772 0.451221543453749 2585 16482810
SGTC_869 0564-0080 44.1 µM -0.125289395622292 0.474925079642511 no 1773 0.45014722354968 2672 6843321
SGTC_620 0109-0052 432 µM -0.127344668965947 0.474081771886708 no 1774 0.449333803673333 2656 493037
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.127888707331304 0.473858564524685 no 1775 0.449118523951556 2943 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1178 0988-0033 191 µM -0.127999988319109 0.47381290931258 no 1776 0.449074491142671 2761 5392207
SGTC_1405 3909-7894 12 µM -0.128176962989321 0.47374030268497 no 1777 0.449004465272132 2726 7104060
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.128666877958073 0.473539311960478 no 1778 0.448810622533442 2771 5282362
SGTC_2985 9022375 71.43 µM -0.129848327562757 0.473054642570706 no 1779 0.448343213341646 2835 4939335
SGTC_1853 st056710 91.2 µM -0.131668710425691 0.47230794012652 no 1780 0.447623167730992 2823 269167
SGTC_1039 k821-0043 94 µM -0.132470852539154 0.471978940363286 no 1781 0.447305938062491 2635 15992768
SGTC_2046 4110841 106 µM -0.132667356183494 0.471898347012514 no 1782 0.447228230299755 2686 44119630 YMR134W ERG29
SGTC_2992 9074591 71.4286 µM -0.133173174526804 0.47169089766138 no 1783 0.44702821274082 2645 17741321
SGTC_96 0929-0093 37.281 µM -0.133592287557518 0.471519014245819 no 1784 0.446862491578703 2621 6991579
SGTC_2603 homopterocarpin 100 µM -0.133614919628859 0.47150973270531 no 1785 0.446853542912518 2742 101795 A weak amylase inhibitor.
SGTC_2133 5320837 200 µM -0.133803276725645 0.471432486994953 no 1786 0.446779068022933 2762 2841355
SGTC_1679 SEC14.276 6.7 µM -0.133823211072974 0.471424311932741 no 1787 0.446771186251222 2806 1005053 YMR079W SEC14
SGTC_1876 myriocin 605 nM -0.13409096905293 0.471314505736624 no 1788 0.446665320401334 2714 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_376 3970-0862 59.1 µM -0.13510013925077 0.470900669798693 no 1789 0.446266350040949 2729 3135186
SGTC_2289 7946404 165.07 µM -0.135751830656705 0.470633443811856 no 1790 0.446008736000698 2668 1246120 YPR165W RHO1
SGTC_3080 9117754 49.47 µM -0.136021010090863 0.470523070667599 no 1791 0.44590233583833 2799 9550191
SGTC_1353 1498-1206 8.11 µM -0.138197081860494 0.469630887706081 no 1792 0.445042330653797 2646 6756808
SGTC_836 0330-0104 1.35 µM -0.13828073375867 0.469596593690635 no 1793 0.445009275728271 2670 46494820
SGTC_518 1021-0119 62.6 µM -0.139727616809813 0.469003463979968 no 1794 0.444437602697941 2713 1097762
SGTC_1928 4'-methoxychalcone 40.3 µM -0.140273815871815 0.468779575036665 no 1795 0.444221825831924 2877 641818
SGTC_1054 3429-0080 167 µM -0.140562448177863 0.468661267607719 no 1796 0.444107807821951 2749 1162877
SGTC_2791 5663188 71.43 µM -0.140663563100182 0.468619822289692 no 1797 0.444067865631404 2780 54690634
SGTC_1330 1469-0054 61.8 µM -0.141431392112312 0.468305113128716 no 1798 0.443764578096639 2805 7102664
SGTC_2512 diallyl trisulfide 49.23 µM -0.142684139210579 0.467791693776746 no 1799 0.443269821807636 2639 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2425 5628681 7.85 µM -0.142885336765197 0.467709240988629 no 1800 0.44319036965327 2749 5714958
SGTC_3149 9097855 49.47 µM -0.144300997649067 0.467129128240462 no 1801 0.442631395271763 2784 25236625 YMR079W SEC14
SGTC_1693 xanthone 101.9 µM -0.146091073227968 0.466395687089099 no 1802 0.441924746671833 2709 7020 An insecticide.
SGTC_3001 9076041 71.4286 µM -0.146346175495378 0.466291174196948 no 1803 0.441824057724583 2680 16004211
SGTC_2153 5569715 200 µM -0.149740412174116 0.464900812802272 no 1804 0.440484711654174 2668 2054701
SGTC_3227 9130768 49.47 µM -0.150510157274852 0.464585565588214 no 1805 0.440181068837901 2687 17720899
SGTC_1494 4358-1428 177 µM -0.152111808988606 0.463929684539972 no 1806 0.439549375183618 2786 1564571
SGTC_802 4112-3352 742 µM -0.153727003924962 0.463268356768328 no 1807 0.43891249590621 2828 704594
SGTC_847 0342-0274 5.54 µM -0.154048600671989 0.463136693785152 no 1808 0.43878570755669 2791 18097
SGTC_828 2074-0507 139 µM -0.154597223520477 0.462912094743812 no 1809 0.438569429495459 2808 X828
SGTC_32 0928-0142 34.1 µM -0.155358157016533 0.462600598077365 no 1810 0.438269484723317 2688 2244242
SGTC_275 trichlorophene 5.69 µM -0.156164993653761 0.462270335499538 no 1811 0.437951484583725 2767 62616
SGTC_667 1498-1044 59 µM -0.156548603615147 0.462113321478087 no 1812 0.437800305662006 2712 6739982
SGTC_119 0121-0043 24.815 µM -0.156845640703114 0.461991746344328 no 1813 0.437683250946957 2673 1092378
SGTC_2594 a-mangostin 100 µM -0.156901316127605 0.461968959190233 no 1814 0.437661311293491 2834 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_803 4488-1585 147 µM -0.157061267002445 0.461903494282053 no 1815 0.437598281556002 2809 747204
SGTC_933 2914-0560 114 µM -0.157780355162311 0.461609197692719 no 1816 0.437314939525946 2873 463887
SGTC_1628 st004252 77.7 µM -0.162116259935007 0.459835120996624 no 1817 0.43560715099832 2841 692968
SGTC_3260 9137109 49.47 µM -0.162434246868566 0.459705044650585 no 1818 0.435481951916334 2785 17478346
SGTC_221 trifluoperazine 10.304 µM -0.162598827249357 0.459637722776718 no 1819 0.43541715521212 2705 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1321 1326-2144 215 µM -0.162779079677494 0.459563991554142 no 1820 0.435346190278333 2814 3513030
SGTC_2066 5222451 176 µM -0.1630105079306 0.45946932919301 no 1821 0.435255080602349 2691 2281147
SGTC_1344 1488-0097 29.1 µM -0.163195968407608 0.459393470940397 no 1822 0.435182070199948 2784 747966
SGTC_946 3434-1334 87.4 µM -0.164084344926539 0.459030121938216 no 1823 0.434832372857232 2827 4047976
SGTC_1188 1403-0014 4.57 µM -0.16467261087402 0.458789537990451 no 1824 0.434600837996606 2719 9614867
SGTC_2543 pimpinellin 60.67 µM -0.165037580264281 0.458640283529654 no 1825 0.43445720141828 2701 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1511 0906-3109 28.5 µM -0.165896051031162 0.458289234395869 no 1826 0.434119377627073 2682 2882180
SGTC_2211 7117706 200 µM -0.16729940878506 0.457715438181247 no 1827 0.433567234652364 2748 822771
SGTC_43 0570-0105 72.5 µM -0.168503379466287 0.457223236300989 no 1828 0.433093642627774 2703 1114046 YDL195W SEC31
SGTC_2246 7293507 91.5585 µM -0.168894678986763 0.457063281080868 no 1829 0.432939742313468 2897 887656
SGTC_269 exalamide 29 µM -0.170065538244739 0.456584699473864 no 1830 0.432479297584526 2739 3316 A derivative of salicylamide.
SGTC_3005 9076496 71.4286 µM -0.171047177300438 0.456183508972192 no 1831 0.432093335023491 2768 21368410
SGTC_2935 9038016 29.96 µM -0.171068759811417 0.456174688818576 no 1832 0.432084849900766 2779 6463195
SGTC_1903 st060211 78.3 µM -0.171467832219512 0.456011603259976 no 1833 0.431927960999424 2876 688960
SGTC_3145 9085516 49.47 µM -0.172205392921812 0.455710210067494 no 1834 0.431638029140217 2781 25236195
SGTC_730 1436-0052 41.2 µM -0.172861032619563 0.455442314064509 no 1835 0.431380330976625 2706 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2179 6298986 200 µM -0.173376577550476 0.455231675352416 no 1836 0.431177717348596 2824 738374
SGTC_906 1165-0455 526 µM -0.173670564139258 0.455111565445804 no 1837 0.431062186174586 2699 3252859
SGTC_2640 pentamidine 10.38 µM -0.173772492446339 0.455069923008884 no 1838 0.431022131652583 2811 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1507 4075-3230 155 µM -0.174825561302039 0.454639724562915 no 1839 0.430608351315345 2673 659771
SGTC_623 k072-0108 16.9 µM -0.17485227411903 0.454628812564182 no 1840 0.43059785608784 2800 5382803
SGTC_218 alverine citrate 93.75 µM -0.174955873549821 0.454586493245935 no 1841 0.430557153259421 2824 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_590 k048-0076 22.4 µM -0.176762423591631 0.453848619135627 no 1842 0.429847502922066 2825 6832814
SGTC_1227 3909-8010 46.6 µM -0.176918038826407 0.453785066476948 no 1843 0.429786384596481 2729 15982272
SGTC_1729 st035615 45.989 µM -0.178067440551126 0.453315692024532 no 1844 0.429335006010665 2851 17385451
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.179544143765073 0.452712755176688 no 1845 0.428755229358385 2752 140250 A respiratory chain inhibitor.
SGTC_2846 9008642 19.48 µM -0.180041189246459 0.452509836321276 no 1846 0.428560116083038 2855 2992898
SGTC_143 4032-1194 15.74 µM -0.18095771646303 0.452135696575464 no 1847 0.428200382694482 2669 1806963
SGTC_2447 5741742 33.78 µM -0.181338889762174 0.451980108582934 no 1848 0.428050791196509 2809 1776504
SGTC_3302 9125395 16.351 µM -0.181430566946235 0.451942688726799 no 1849 0.428014814018464 2780 17599668
SGTC_991 3996-0057 64.7 µM -0.18160258703849 0.451872476475789 no 1850 0.427947309224492 2818 715343
SGTC_1557 sumaresinolic acid 42.3 µM -0.181950796013334 0.451730355037272 no 1851 0.427810670160329 2724 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_3179 9107801 49.47 µM -0.183682903082266 0.451023488082763 no 1852 0.427131111029408 2755 4818259
SGTC_1354 1498-1681 81 µM -0.184719212421831 0.450600647899463 no 1853 0.426724638081772 2816 5754243
SGTC_1550 gossypolone 36.6 µM -0.185144066516271 0.45042731295661 no 1854 0.426558019475355 2739 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1954 st077032 68.9 µM -0.185146488478232 0.450426324854714 no 1855 0.426557069671687 2815 698907
SGTC_3071 9117417 49.47 µM -0.185259725896911 0.4503801270701 no 1856 0.426512662630788 2821 45595590 YGL055W OLE1
SGTC_355 1311-2252 105 µM -0.18645608918093 0.449892084608433 no 1857 0.426043555359421 2763 5338538
SGTC_1924 st058459 75.1 µM -0.188189889742844 0.449184935546031 no 1858 0.425363898855483 2721 688683
SGTC_50 0929-0078 56.389 µM -0.18840064330811 0.449098988410709 no 1859 0.425281297720175 2792 1377751
SGTC_480 am 92016 50 µM -0.189273695119081 0.448742975779408 no 1860 0.424939155465404 2797 2129 K+ channel blocker.
SGTC_1571 st070080 73.4 µM -0.189286626056122 0.448737703117807 no 1861 0.424934088355393 2876 4315245
SGTC_168 3970-0862 530.542 µM -0.189806346384693 0.448525791763926 no 1862 0.424730441303439 2816 3135186
SGTC_3150 9097574 49.47 µM -0.190173380920596 0.448376145531892 no 1863 0.42458663470447 2851 17217476
SGTC_1071 trifluoperazine 6.31 µM -0.191290853203138 0.447920578362733 no 1864 0.42414886343003 2891 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.192165427575948 0.447564082840368 no 1865 0.423806312984483 2747 16623 A steroid.
SGTC_746 1095-0025 46.6 µM -0.192537192027593 0.44741255638191 no 1866 0.42366071891443 2915 6749286
SGTC_1522 st012842 45.6 µM -0.19361672289542 0.446972596920819 no 1867 0.423238001498481 2701 3491067 YOR116C RPO31
SGTC_1545 lovastatin 49.4 µM -0.193641683419918 0.446962425106115 no 1868 0.423228228621541 2797 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2004 4023728 41.89 µM -0.19379543732849 0.446899768688087 no 1869 0.423168029885656 2854 360084 YDR527W RBA50
SGTC_3048 9093155 49.47 µM -0.19380412198116 0.446896229635617 no 1870 0.423164629667149 2763 25236002
SGTC_3163 9099914 49.47 µM -0.19566334711701 0.446138681113324 no 1871 0.422436837297624 2833 16268368
SGTC_1471 k673-0312 37 µM -0.195688307838188 0.446128512101252 no 1872 0.422427068236257 2767 24099884
SGTC_856 0433-0016 11.3 µM -0.196472339132717 0.44580911537385 no 1873 0.42212024045055 2833 3911780
SGTC_466 geldanamycin 89.2 µM -0.196720044601804 0.445708213033222 no 1874 0.422023311635004 2808 5288382 HSP90 inhibitor.
SGTC_2419 paclitaxel 166.5 µM -0.19815251142398 0.445124769629117 no 1875 0.421462870547343 2693 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_862 0452-0056 10.2 µM -0.198557325216319 0.444959910549562 no 1876 0.421304519195058 2749 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2294 7971431 200 µM -0.199450795086833 0.444596081627546 no 1877 0.420955064914187 2890 5741572
SGTC_3011 9081274 71.4286 µM -0.2004411438756 0.444192857296345 no 1878 0.420567792086723 2791 6625322
SGTC_3259 9138485 49.47 µM -0.201366245513484 0.443816250760484 no 1879 0.420206103387278 3046 17646153
SGTC_366 0181-0206 4.31 µM -0.202157656676734 0.443494109530652 no 1880 0.419896737358858 2899 274874
SGTC_3214 9129694 49.47 µM -0.20249152608269 0.443358220307806 no 1881 0.419766241204398 2881 17158655
SGTC_266 formosanin C 406 nM -0.20379044259229 0.442829607780942 no 1882 0.419258630912411 2898 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1753 st043925 64 µM -0.205158960153216 0.442272780207874 no 1883 0.418723966223389 2866 670181
SGTC_99 0109-0120 622.8 µM -0.205275825416086 0.442225234899356 no 1884 0.418678315198907 2796 759414
SGTC_2191 5911152 200 µM -0.205379523205583 0.442183047325067 no 1885 0.418637808695542 2810 2875902
SGTC_2305 7443522 69.23 µM -0.206296214393186 0.441810136631259 no 1886 0.418279767707746 2782 5415886
SGTC_1534 6-azauridine 81.6 µM -0.206771560966662 0.441616785555086 no 1887 0.418094133613532 2745 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1251 0490-5699 265 µM -0.206810462794443 0.441600962536171 no 1888 0.418078942335619 2888 3883818
SGTC_1346 1488-2224 62.4 µM -0.208964057397476 0.44072515060906 no 1889 0.417238148608547 2807 3722427
SGTC_1784 st039334 36.3 µM -0.209501968458854 0.440506440991823 no 1890 0.417028199436933 3024 3496984
SGTC_2627 acetyl isogambogic acid 100 µM -0.209775419356856 0.440395265362568 no 1891 0.416921479355354 2876 6857789 A caspase activator and apoptosis inducer.
SGTC_826 1683-5028 118 µM -0.209910060594692 0.440340526641519 no 1892 0.416868934971361 2854 722377
SGTC_2950 9072895 21.46 µM -0.212037558545751 0.439475739219126 no 1893 0.416038866486053 2889 17332245
SGTC_617 3770-0098 35 µM -0.212459900774782 0.439304099361141 no 1894 0.415874129092349 2789 5962639
SGTC_1555 citronellol 128 µM -0.213074613677739 0.439054300470584 no 1895 0.415634382659929 2846 8842 A terpine precursor.
SGTC_1177 0983-0204 23.6 µM -0.214446538490632 0.438496883501992 no 1896 0.415099426603666 2915 766818
SGTC_2865 9030313 51.95 µM -0.214948722175177 0.438292875275658 no 1897 0.414903648894486 2761 42562754
SGTC_2596 sinensetin 100 µM -0.21585795120613 0.437923549789923 no 1898 0.414549237221005 2846 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2930 9013230 14.89 µM -0.218269006778882 0.436944450511246 no 1899 0.413609760644547 2930 2995857
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.218557153964469 0.436827463282834 no 1900 0.413497516008768 2773 165521
SGTC_146 3448-8650 53.125 µM -0.220504476739149 0.4360369991375 no 1901 0.412739143122465 2832 2891488 YIL048W NEO1
SGTC_1970 st070122 35.8 µM -0.220752814288487 0.435936211379442 no 1902 0.41264245294001 2967 102928
SGTC_1971 st069429 63.5 µM -0.220843699023344 0.435899326862628 no 1903 0.412607068308593 2939 1246522 YGL099W LSG1
SGTC_1986 st071812 45 µM -0.221647201948103 0.435573258797204 no 1904 0.412294267219091 2812 11838594
SGTC_3287 9117173 37.0625 µM -0.222115025808256 0.435383432202741 no 1905 0.412112170548774 2855 2789709
SGTC_2513 baicalein 25.65 µM -0.222173782032339 0.435359592029247 no 1906 0.412089301498321 2842 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1055 3448-0672 86 µM -0.223289189676337 0.434907063160296 no 1907 0.411655220140387 2948 748378
SGTC_1053 3366-3204 134 µM -0.22377959230246 0.434708130248937 no 1908 0.411464405137965 2851 3632071 YPR165W RHO1
SGTC_2780 5215298 71.43 µM -0.224318221906422 0.434489653005855 no 1909 0.411254849214307 2940 2834131
SGTC_509 pifithrin 175 µM -0.224608263457313 0.434372015548004 no 1910 0.411142017914462 2828 4817 A p53 inhibitor.
SGTC_1133 3473-0247 50 µM -0.225586755893615 0.433975193399383 no 1911 0.410761421306908 2870 711311
SGTC_2460 5552655 174.22 µM -0.227155400401017 0.433339177350727 no 1912 0.410151453249218 2918 5401989
SGTC_2207 7258803 200 µM -0.227755909228924 0.433095743145262 no 1913 0.409918002587149 2883 3666799
SGTC_1768 st044301 37.178 µM -0.227893133019801 0.433040118939182 no 1914 0.409864660664515 2852 3931349
SGTC_564 3555-0129 330 µM -0.228249228118351 0.432895780573967 no 1915 0.409726246406804 2806 563260
SGTC_1280 0880-0253 10.1 µM -0.228458576405544 0.432810928235039 no 1916 0.409644877922803 2841 6836607
SGTC_1235 benzylparaben 21.5 µM -0.230254959467767 0.432082952077622 no 1917 0.408946828722131 2912 7180
SGTC_574 1315-0397 40 µM -0.231486610225332 0.431583964212958 no 1918 0.408468393236654 2804 6794277
SGTC_2652 actinonin 100 µM -0.233251205123362 0.430869251117626 no 1919 0.407783173128153 2800 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.233805411224707 0.430644827861731 no 1920 0.407568024225049 2948 521171
SGTC_3349 9149703 23.001 µM -0.233829962791708 0.430634886333188 no 1921 0.40755849368111 2783 4910494
SGTC_2347 9049783 174.81 µM -0.233884343178177 0.430612866544342 no 1922 0.407537384239107 2986 6467988 YPL169C MEX67
SGTC_1830 st055982 50.3 µM -0.235000272349152 0.430161050539804 no 1923 0.407104260917879 2827 455313 An antimicrobial agent.
SGTC_567 1080-0542 68.4 µM -0.235072504453417 0.430131808440183 no 1924 0.407076229526044 2821 5950415
SGTC_357 1325-0123 420 µM -0.236811563938587 0.429427891958286 no 1925 0.406401489988328 2950 1098503
SGTC_1587 estradiol valerate 56.1 µM -0.238403368275265 0.428783776299078 no 1926 0.405784127614075 2994 13791 A steroid.
SGTC_1617 st002906 78 µM -0.238935974861354 0.428568301962719 no 1927 0.405577614712294 2814 5150859
SGTC_1285 0929-0069 65.5 µM -0.24017543660656 0.428066940834778 no 1928 0.405097127590537 2861 1206237
SGTC_1158 4092-0494 91.8 µM -0.242681633780577 0.427053541927589 no 1929 0.404126018156186 2966 1148199
SGTC_1114 scopoletin 1.73284 µM -0.244036533657354 0.426505878363741 no 1930 0.403601262670826 2966 5280460 A coumarin with genotoxic properties.
SGTC_1449 4112-4002 201 µM -0.245643466313564 0.425856524460484 no 1931 0.402979119334038 2878 2059539
SGTC_1667 st014849 34.6 µM -0.247434746380608 0.425132913624856 no 1932 0.402285893142772 2802 5348460
SGTC_2470 5664817 21.68 µM -0.247565524736629 0.425080093857671 no 1933 0.402235293867219 2823 2859561
SGTC_3157 9099274 49.47 µM -0.247826955164381 0.42497450936031 no 1934 0.402134149088011 2940 17217662
SGTC_860 0443-0016 25.1 µM -0.248998944525796 0.424501241617208 no 1935 0.40168079892708 2842 5337942
SGTC_2272 7805186 180 µM -0.250282505474372 0.423983044392366 no 1936 0.401184442316142 2979 2956062 YPR165W RHO1
SGTC_349 k015-0014 24 µM -0.250841094837658 0.423757572549761 no 1937 0.400968483989177 2812 2196908
SGTC_1668 st014914 51.6 µM -0.250985742172 0.423699190431738 no 1938 0.400912566270712 2885 2839556
SGTC_1956 st077085 54 µM -0.252522447053672 0.423079053931118 no 1939 0.400318632967834 2894 24208685
SGTC_2384 9036245 200 µM -0.253495217187178 0.422686591404921 no 1940 0.399942778315961 2900 6462766
SGTC_1074 carmofur 3.8 µM -0.255618371779758 0.421830275146562 no 1941 0.39912276548523 2857 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2696 st077691 74.316 µM -0.255814177418265 0.421751320851817 no 1942 0.399047163043119 2998 757133
SGTC_3207 9114163 49.47 µM -0.258586848931515 0.420633641431297 no 1943 0.397977015621376 3142 849233
SGTC_1882 5615643 20 µM -0.260090201442472 0.420027898404132 no 1944 0.39739709800999 2856 2253075
SGTC_1720 st037298 9.481 µM -0.260230803606548 0.419971255498939 no 1945 0.397342872357293 2961 597396
SGTC_2753 fluvastatin 17.09 µM -0.261804246643185 0.419337492500868 no 1946 0.396736182443192 2950 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2767 sibutramine 71.45 µM -0.262450256476859 0.419077348378681 no 1947 0.396487165527499 3061 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1315 1237-0019 3.69 µM -0.262675589811401 0.418986616369042 no 1948 0.396400316385523 2981 825140
SGTC_618 k072-0232 33.2 µM -0.264121454706861 0.418404531693161 no 1949 0.395843166131163 2970 5872756 YGL099W LSG1
SGTC_1718 roemerine 11.9335 µM -0.264142591550664 0.418396023621756 no 1950 0.395835022824891 3016 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1261 0712-0010 12.7 µM -0.264375487857465 0.418302279968479 no 1951 0.395745298818415 3039 2840123
SGTC_1037 k284-1091 78.7 µM -0.265353882653281 0.417908514678525 no 1952 0.39536842966869 2845 3334711
SGTC_731 3966-0296 387 µM -0.266568869647872 0.417419644938655 no 1953 0.394900563479494 2877 660956
SGTC_560 2332-1943 155 µM -0.268312816580001 0.416718162817297 no 1954 0.394229270802606 2860 21177716
SGTC_2045 5106652 78.05 µM -0.268518229968135 0.416635555109335 no 1955 0.394150222230939 3014 673349
SGTC_2393 9031399 185.94 µM -0.26870659414852 0.416559807035114 no 1956 0.394077738483014 3042 1526623 YDL150W RPC53
SGTC_616 4092-0450 108 µM -0.268924991965063 0.416471985224514 no 1957 0.393993702191619 2940 787165
SGTC_3339 9145883 14.936 µM -0.268966382440355 0.416455341816951 no 1958 0.3939777762972 3023 2030670
SGTC_2327 6189656 200 µM -0.271081129846783 0.415605186654504 no 1959 0.393164317290299 3006 5349088
SGTC_2592 piperlongumine 83.33 µM -0.27135807132754 0.415493881839544 no 1960 0.393057823396207 2964 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1527 coumarin 137 µM -0.273788430363049 0.414517394493532 no 1961 0.392123607627691 3079 323 A hepatotoxic, DNA x-linker.
SGTC_810 3825-7150 143 µM -0.273974208522089 0.414442772841945 no 1962 0.392052221094167 3079 22330411 YGL099W LSG1
SGTC_1228 0124-0032 52.5 µM -0.278193407012415 0.412748880730553 no 1963 0.39043194781486 2976 X1228
SGTC_1022 4477-0945 21.3 µM -0.27865871212195 0.412562172353941 no 1964 0.390253375389525 2895 4648966
SGTC_1116 jasmonic acid 1.58368 µM -0.279046132554675 0.41240673108195 no 1965 0.390104710811051 3056 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_755 1995-0008 37.3 µM -0.279184594902207 0.412351180390572 no 1966 0.390051582646015 2984 689533
SGTC_3327 9140648 26.9345 µM -0.280703009891359 0.411742112149941 no 1967 0.389469099989083 3041 8029710
SGTC_3065 9113888 49.47 µM -0.280985387289143 0.411628868026241 no 1968 0.389360803883044 3104 16648368
SGTC_1192 1488-0095 21.4 µM -0.281279666979521 0.411510858461402 no 1969 0.389247952206732 2983 915875
SGTC_585 0kpi-0023 191 µM -0.282438331291661 0.411046298552166 no 1970 0.388803713372289 3032 64601
SGTC_1126 isoteolin 1.0172 µM -0.282838818233961 0.41088575454829 no 1971 0.388650198056196 2895 133323
SGTC_307 1501-1223 22.3 µM -0.282959416537965 0.410837412987216 no 1972 0.38860397352053 2996 2830329
SGTC_2836 9010338 19.48 µM -0.282978306852664 0.410829840969374 no 1973 0.38859673313019 2921 2994051
SGTC_2802 7925815 54.55 µM -0.284068775610853 0.410392792492922 no 1974 0.388178837564619 2890 1262923
SGTC_477 mead ethanolamide 10 µM -0.285100313216309 0.409979465395797 no 1975 0.387783645046624 2874 16061185
SGTC_963 1269-2853 151 µM -0.285679598331634 0.409747395295371 no 1976 0.387561765972114 2919 3668223
SGTC_1035 k081-0041 55.2 µM -0.286224637982871 0.409529073294012 no 1977 0.387353037194368 3066 731709
SGTC_2271 7849410 118.62 µM -0.286425366832168 0.409448676072298 no 1978 0.387276174130246 3006 972430
SGTC_2812 7970281 58.44 µM -0.286747911975858 0.409319496174736 no 1979 0.387152674443605 3055 2233435
SGTC_181 1447-1644 8.07 µM -0.286894620267287 0.409260742502772 no 1980 0.387096504913001 3018 534600
SGTC_595 3909-8003 73.7 µM -0.287004060619031 0.409216915206178 no 1981 0.387054605527028 3034 699517
SGTC_2160 5660466 132.927 µM -0.287385067220567 0.409064343326493 no 1982 0.386908746905871 2953 2859134
SGTC_2250 alverine citrate 130 µM -0.28832785084753 0.408686870366697 no 1983 0.386547895026803 2863 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1828 st055811 49 µM -0.288554641720358 0.408596080159388 no 1984 0.386461105095482 3067 5877589
SGTC_2699 st077704 54.6 µM -0.288761700584274 0.408513193465171 no 1985 0.386381871308207 2974 645852
SGTC_3197 9113331 49.47 µM -0.289104779449233 0.408375866296807 no 1986 0.386250598114288 3149 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_3221 9128209 49.47 µM -0.290343639840811 0.407880070633348 no 1987 0.385776678107046 2951 16460723
SGTC_2 0422-0095 29 µM -0.290396014259602 0.407859113476786 no 1988 0.385756646278626 2958 6790840
SGTC_1118 chelidonine 707.474 nM -0.290640321686961 0.407761359522664 no 1989 0.385663209182425 3050 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_3143 9086658 49.47 µM -0.291058109993634 0.40759420452534 no 1990 0.38550343847835 2972 25236626
SGTC_51 1013-0126 23.419 µM -0.291665161150818 0.407351356401566 no 1991 0.385271324458077 3193 1627850
SGTC_998 3996-0085 177 µM -0.293004509510285 0.406815682095094 no 1992 0.384759352401668 2982 715391
SGTC_916 4466-0038 42 nM -0.293326906888708 0.406686764787997 no 1993 0.384636144488936 3113 5722064 YGL116W CDC20
SGTC_2497 7-hydroxyflavone 100 µM -0.293400518958992 0.40665733088591 no 1994 0.3846080144124 3090 5281894
SGTC_1045 1348-1485 165 µM -0.293584142166377 0.406583911156278 no 1995 0.384537847387947 2904 6810614
SGTC_563 tetrahydrosecaminediol 614 µM -0.293671044409953 0.40654916538999 no 1996 0.38450464118366 3071 334274 A psychoactive constituent of the cannabis plant.
SGTC_1961 st076550 68.7 µM -0.293760830801109 0.406513267239628 no 1997 0.38447033380823 3039 1579337
SGTC_1003 4049-0218 100 µM -0.29393372468578 0.406444143490929 no 1998 0.384404273612872 3082 295161
SGTC_340 k038-0059 454 µM -0.294383243660977 0.406264437442122 no 1999 0.384232534778299 2928 23733424
SGTC_2817 7995342 71.43 µM -0.296483193067861 0.405425194179954 no 2000 0.383430550152949 2879 18879975
SGTC_1282 0886-0010 32.4 µM -0.297066346152778 0.405192214411559 no 2001 0.383207928533809 3090 2836211 YNL267W PIK1
SGTC_2423 st077119 87.2 µM -0.29783463948665 0.404885319200208 no 2002 0.382914687576217 2914 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1076 itraconazole 331 nM -0.297936618565411 0.40484458799209 no 2003 0.382875769406692 2928 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1061 3448-9325 110 µM -0.298109792012781 0.404775423581721 no 2004 0.382809684113525 2940 723482
SGTC_263 alizarin 107.927 µM -0.298450397591207 0.404639396489219 no 2005 0.382679714445384 2971 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2793 7325131 81.82 µM -0.299300232156583 0.404300049732028 no 2006 0.382355488733767 3000 4176441
SGTC_1772 st048439 82.2 µM -0.3000938588839 0.403983212279965 no 2007 0.382052781680378 3017 2927068 YDL195W SEC31
SGTC_1429 4049-0205 9.46 µM -0.300587541207021 0.403786152582283 no 2008 0.381864516513867 2947 22774478
SGTC_1090 efavirenz 20.7 µM -0.301755768130675 0.403319937010183 no 2009 0.38141912590906 2982 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1159 4092-0538 61.2 µM -0.30229342964526 0.403105413371786 no 2010 0.381214193290779 2947 717301
SGTC_1645 Cervolide 78 µM -0.302857260265454 0.402880479744952 no 2011 0.380999321952441 3003 23173 A fragrance.
SGTC_619 1652-1634 108 µM -0.303047626859188 0.402804542474106 no 2012 0.380926783048228 2968 5400454
SGTC_3158 9100007 49.47 µM -0.303917837988391 0.402457461815038 no 2013 0.380595243728824 2953 19297233
SGTC_3292 9120825 59.784 µM -0.304081755615582 0.402392092440054 no 2014 0.380532803013237 3102 24824900
SGTC_1246 0422-0085 105 µM -0.304131498953216 0.402372255632538 no 2015 0.380513855028415 3086 264295
SGTC_2277 7947813 106.88 µM -0.304808116434457 0.402102456933303 no 2016 0.380256149747357 3155 1246798
SGTC_2328 6201408 200 µM -0.30482778059734 0.402094616618426 no 2017 0.38024866099423 3070 2890418
SGTC_2711 st079103 59.1 µM -0.305390152041671 0.401870409713256 no 2018 0.380034510657015 2995 54693780
SGTC_2298 7976326 193.81 µM -0.305672361081335 0.401757910446651 no 2019 0.37992705966438 2925 2235818
SGTC_2127 5253358 187.912 µM -0.306248335141349 0.401528330530793 no 2020 0.379707786514592 2871 20612
SGTC_3191 9110352 49.47 µM -0.30646463594762 0.401442123059039 no 2021 0.379625450848767 2964 17122424
SGTC_3336 9143619 71.43 µM -0.306762743265934 0.401323319166955 no 2022 0.379511984190232 3058 45595730
SGTC_3038 9091290 49.47 µM -0.306888297219428 0.401273285223558 no 2023 0.379464198506517 3102 25236843
SGTC_587 k089-0003 57 µM -0.307060708604007 0.401204580973309 no 2024 0.379398581941154 2952 9659696
SGTC_1361 1608-0041 5.61 µM -0.307130172901646 0.401176900993386 no 2025 0.379372146103426 2967 X1361
SGTC_1694 st024011 44.9 µM -0.307336732896381 0.401094594353725 no 2026 0.379293539463798 3023 2787533
SGTC_345 1362-0200 395 µM -0.308074706843644 0.400800574474234 no 2027 0.379012743425509 2968 1419823
SGTC_829 1635-0120 117 µM -0.308457562617775 0.400648061121686 no 2028 0.378867093524206 3084 285054
SGTC_2124 5246320 200 µM -0.309117571591813 0.400385177367237 no 2029 0.378616046567152 3036 579342
SGTC_1283 0922-0125 16.4 µM -0.309785143480195 0.400119327178553 no 2030 0.378362175009372 3046 3360884
SGTC_1808 st050063 61.5 µM -0.311587036569707 0.39940198247111 no 2031 0.377677193716019 3113 4011993
SGTC_675 1309-0189 238 µM -0.311790761000172 0.399320899841515 no 2032 0.377599772973955 3000 4246530
SGTC_1208 2323-2347 50.3 µM -0.312271524290503 0.399129572552081 no 2033 0.377417089542849 3107 5412760
SGTC_1237 0330-0133 46.1 µM -0.315765749075988 0.397739721765833 no 2034 0.376090158617852 2941 X1237 YHR072W ERG7
SGTC_2381 9035592 200 µM -0.315829456998173 0.397714393508341 no 2035 0.376065979089832 3023 4749657
SGTC_1078 idebenone 36.1 µM -0.316987775949269 0.397253957768175 no 2036 0.37562643885352 3032 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_3047 9092122 49.47 µM -0.31740816295008 0.397086887869416 no 2037 0.375466957038743 3028 17173831
SGTC_3125 9127534 49.47 µM -0.317683916515835 0.396977308340179 no 2038 0.375362356227274 3036 1639235
SGTC_820 1582-0060 59.9 µM -0.317924260225874 0.396881806686998 no 2039 0.375271194808362 3003 3848840
SGTC_1563 conessine 56.1 µM -0.318045774022563 0.39683352498716 no 2040 0.375225107756493 3070 441082 An anti-amoebic, histamine inhibitor.
SGTC_478 N-arachidonylglycine 10 µM -0.318483264135888 0.396659707898993 no 2041 0.375059193784171 3055 5283389
SGTC_2223 6903751 107.57 µM -0.318528697435182 0.396641658190132 no 2042 0.375041964961162 3054 5598863
SGTC_414 piperonyl butoxide 100 µM -0.319041883450649 0.396437795402471 no 2043 0.374847376317846 2962 5794 A potent inhibitor of cytochrome P450.
SGTC_488 nitrendipine 139 µM -0.320269758610029 0.395950137850816 no 2044 0.37438192294301 2962 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_596 1155-0152 116 µM -0.320768738762742 0.395752011544968 no 2045 0.374192825683376 2997 280313
SGTC_1690 st023502 41.2 µM -0.321279974985989 0.395549046746877 no 2046 0.373999115159842 3056 24207482
SGTC_1359 1582-0056 520 nM -0.321427171299856 0.395490613902938 no 2047 0.373943347475341 3074 3661189
SGTC_2115 tiliquinol 12.7705 µM -0.321578408153897 0.395430579523865 no 2048 0.373886051715497 3046 71208 A bioactive hydroxyquinoline.
SGTC_936 3005-4620 401 µM -0.323356272446398 0.394725032004237 no 2049 0.373212720845538 3177 777207
SGTC_353 1988-1175 58.3 µM -0.323580538374534 0.394636056276206 no 2050 0.373127812016002 2884 2788357
SGTC_2002 4023503 131 µM -0.325981857499841 0.393683697335117 no 2051 0.372219040832204 3121 4736863 YCR052W RSC6
SGTC_222 nsc-310342 10.666 µM -0.326073942177724 0.393647189331973 no 2052 0.372184205821484 3064 432556
SGTC_330 1488-0319 80.1 µM -0.326119354722743 0.393629185363446 no 2053 0.372167026947991 3048 6846614
SGTC_1643 st009866 20.2 µM -0.326460415146149 0.393493977988661 no 2054 0.372038017121697 3075 3156273 YOR207C RET1
SGTC_1904 st060225 78 µM -0.326712806268848 0.393393930257492 no 2055 0.371942556672633 2980 66595
SGTC_193 1273-0060 1.558 µM -0.327570274589812 0.393054082804534 no 2056 0.371618300168963 2988 2847393 YHR072W ERG7
SGTC_1151 3909-8316 15.3 µM -0.329253333553358 0.392387259421498 no 2057 0.370982106878281 3093 800431
SGTC_2722 naftopidil 47.16 µM -0.330587392920369 0.391858933008841 no 2058 0.370478085136213 3102 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_54 0159-0055 9 µM -0.330683804371393 0.391820758975332 no 2059 0.370441668471268 3220 3319099
SGTC_334 1502-1024 68.5 µM -0.330758117423961 0.391791335494977 no 2060 0.370413599635885 3083 3296216
SGTC_2421 5690543 90.72 µM -0.332271423805892 0.39119229242605 no 2061 0.369842157885928 3090 3397993
SGTC_769 0302-0231 76 µM -0.333067488529001 0.390877273291151 no 2062 0.369541669996201 3094 571869 YER009W NTF2
SGTC_1478 0453-0656 35.7 µM -0.333233991628505 0.390811393646805 no 2063 0.36947883069564 3065 5258496
SGTC_1399 3562-5772 25 µM -0.333998889696139 0.39050878964712 no 2064 0.369190198251114 2938 23847490
SGTC_2231 micatex 6.853 µM -0.334335218089603 0.390375754572441 no 2065 0.369063308869396 3047 20737 An antifungal of unknown mechanism.
SGTC_2416 tofa 880 nM -0.334568669797034 0.39028342003202 no 2066 0.368975241009836 2987 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3031 9088762 49.47 µM -0.33470345920193 0.390230111105407 no 2067 0.368924395876331 2932 205253
SGTC_2286 7945697 125 µM -0.336863297679059 0.389376181685277 no 2068 0.368109977040099 3054 1245733
SGTC_3321 9137793 26.8275 µM -0.3379785616359 0.388935451588555 no 2069 0.367689671733592 3053 4904192
SGTC_397 arbidol 50 µM -0.338770903003776 0.388622420847155 no 2070 0.36739116125604 3145 131410 A RNA synthesis inhibitor.
SGTC_863 0466-0191 129 µM -0.339342305648856 0.388396721353843 no 2071 0.367175938001367 3128 765160 YPR165W RHO1
SGTC_364 0083-0097 67.7 µM -0.340222419293236 0.388049157210931 no 2072 0.366844518001832 3133 5207356
SGTC_101 0490-5701 117.494 µM -0.340706261435298 0.387858122128423 no 2073 0.36666236223634 3066 4661669
SGTC_2742 clothiapine 36.27 µM -0.340987759677292 0.387746990842838 no 2074 0.366556398245854 3056 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2300 7976697 71.57 µM -0.341012379789443 0.387737271628803 no 2075 0.366547131014951 2980 2236109
SGTC_1495 4469-0029 237 µM -0.342925627955003 0.386982199476638 no 2076 0.365827205597921 2998 793680
SGTC_2832 7992762 51.95 µM -0.344306272137086 0.386437587307357 no 2077 0.365307983926766 2950 2985177
SGTC_3183 9108214 49.47 µM -0.344805893127762 0.386240560678047 no 2078 0.365120151202367 3094 4974831
SGTC_450 aminopyrene 156 nM -0.344890565629746 0.386207172797169 no 2079 0.365088321744375 3125 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1556 plumbagin 1.48 µM -0.346899256517599 0.385415357705474 no 2080 0.364333502610078 3054 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2663 amphotericin b 100 µM -0.348913692222634 0.384621757426085 no 2081 0.363577052752619 3053 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.349308123960034 0.384466424902648 no 2082 0.363429000045788 3089 5379071
SGTC_3164 9100705 49.47 µM -0.349522100417447 0.384382165854835 no 2083 0.363348691021108 3147 17174235
SGTC_2090 5301565 104.445 µM -0.350037864643844 0.384179092127089 no 2084 0.363155140576441 3021 2056344
SGTC_2569 tetrandrine 100 µM -0.350764062028323 0.383893217688405 no 2085 0.362882680284105 3072 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_939 1165-0479 45.3 µM -0.353483269420655 0.382823338381313 no 2086 0.361863084664938 3158 1377347
SGTC_207 4185-0010 4.486 µM -0.354219411201341 0.382533854797037 no 2087 0.361587228717884 3112 3761753
SGTC_2998 9066762 71.4286 µM -0.354450943526242 0.382442819580808 no 2088 0.361500480987821 3222 4945196
SGTC_1082 camptothecin 424.86 nM -0.354545990843223 0.382405450208539 no 2089 0.361464871869918 2856 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_426 0988-0037 14.6 µM -0.355086893490481 0.38219280654403 no 2090 0.361262247592213 3224 5383008
SGTC_3348 9149464 3.537 µM -0.355211351955802 0.382143883533639 no 2091 0.361215630462457 3025 1951442
SGTC_2047 4141938 200 µM -0.356172068535651 0.381766301668668 no 2092 0.360855854115407 3058 3807862
SGTC_3306 9127676 59.7925 µM -0.359374491886562 0.380508495875105 no 2093 0.359657477219447 3102 41905287
SGTC_812 4251-0442 148 µM -0.359649184004786 0.380400664501726 no 2094 0.359554748884029 3173 5723007
SGTC_253 dyclonine 31.25 µM -0.36098420334576 0.379876730361025 no 2095 0.359055627959233 3061 3180 An oral anasthetic.
SGTC_1230 0170-0365 3.77 µM -0.36252250857266 0.379273289143887 no 2096 0.358480803202628 3164 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2341 7987486 176.74 µM -0.362880018285677 0.379133088486059 no 2097 0.358347256948598 3202 1258686
SGTC_20 0481-0013 4.944 µM -0.36296792393896 0.379098617925739 no 2098 0.358314422813459 3078 182045
SGTC_1715 st032160 10.2275 µM -0.363754211012934 0.378790332921427 no 2099 0.35802077892437 3150 5289825
SGTC_2591 skatole 100 µM -0.365725694921156 0.378017699022024 no 2100 0.357284885355446 3163 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_97 0535-0701 19.132 µM -0.366466120165145 0.377727648648896 no 2101 0.357008644537123 3069 2832013 YGL099W LSG1
SGTC_1466 k213-0079 57.5 µM -0.366537087359124 0.377699851943106 no 2102 0.356982171745682 3048 3657981
SGTC_292 k038-0015 474 µM -0.366581796167066 0.377682340548979 no 2103 0.356965494436191 3164 46368540
SGTC_169 k015-0017 16.025 µM -0.366737452233423 0.37762137567078 no 2104 0.356907433638569 3288 1840002
SGTC_1428 4049-0204 61.7 µM -0.367701123853987 0.377244008103609 no 2105 0.356548051230688 3156 X1428
SGTC_655 k060-0012 42 µM -0.369039560918891 0.37672007929861 no 2106 0.356049118693578 3047 5994525
SGTC_1611 st001856 99.4 µM -0.369355503389417 0.376596437258353 no 2107 0.355931379942505 3089 647478
SGTC_322 k048-0136 19.3 µM -0.369390256361274 0.376582837680382 no 2108 0.355918429779259 3150 6823282
SGTC_1570 verbenone 133 µM -0.369868364410201 0.376395759374876 no 2109 0.355740287011343 3227 29025 A natural terpanoid with antifungal properties.
SGTC_1677 st019204 53.9 µM -0.370204134894769 0.37626439350946 no 2110 0.355615197959972 3142 3945625
SGTC_511 blebbistatin 171 µM -0.370642025533323 0.37609309598919 no 2111 0.355452088089411 3209 3476986 A myosin inhibitor.
SGTC_3332 9141069 11.198 µM -0.370676043677958 0.376079789523895 no 2112 0.355439417779493 3027 17332883
SGTC_1375 2910-0797 186 µM -0.371135435795141 0.375900109111911 no 2113 0.355268329435181 3099 742508
SGTC_1146 3579-1023 7 µM -0.372772594044008 0.37525999223078 no 2114 0.354658850907619 3181 X1146
SGTC_1697 st025554 27.742 µM -0.374046239101635 0.374762243693952 no 2115 0.354184957553504 3029 1269519
SGTC_517 1365-0151 113 µM -0.374622237704065 0.374537208239551 no 2116 0.353970716108171 3229 768657
SGTC_2306 7482397 179.52 µM -0.376229352283661 0.373909554795886 no 2117 0.353373197889956 3229 891448
SGTC_2334 9017922 200 µM -0.377105994685623 0.373567325669345 no 2118 0.353047418208565 3183 3163164
SGTC_2701 st077767 14.721 µM -0.377534253234014 0.373400175652708 no 2119 0.352888307009893 3108 5721188
SGTC_3213 9129884 49.47 µM -0.377828913722104 0.373285183008492 no 2120 0.352778846528875 3131 17190742
SGTC_491 tetrandrine 80.3 µM -0.379334120478748 0.372697945237075 no 2121 0.352219882595621 3154 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1295 1013-0063 9.78 µM -0.379371451350786 0.372683384812747 no 2122 0.352206023692489 3203 6826038
SGTC_444 curcumin 90.4 µM -0.382113883123671 0.371614233588798 no 2123 0.351188447268919 3194 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2360 9040895 200 µM -0.382260772883555 0.371556995704902 no 2124 0.351133973991335 3119 4914414
SGTC_1446 4239-0190 62 µM -0.384087801681549 0.370845303159463 no 2125 0.35045668611937 3086 1340085
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.384488536511869 0.370689261694229 no 2126 0.350308195364403 3104 688664
SGTC_2337 9009472 200 µM -0.38695281865814 0.369730167391445 no 2127 0.349395568727161 3276 5742383
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.388179397146095 0.369253086670587 no 2128 0.348941639397394 3105 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2036 5160441 105 µM -0.389416761747041 0.368772014617683 no 2129 0.348483937307177 3127 134534 YIL048W NEO1
SGTC_300 r073-0011 5.04 µM -0.389984539140934 0.368551338542546 no 2130 0.348273989788868 3199 2735780
SGTC_1997 st073024 93.8 µM -0.390595223528507 0.368314034337346 no 2131 0.348048228401596 3205 686268
SGTC_660 4031-1742 102 µM -0.391144726139178 0.368100547521999 no 2132 0.34784513107361 3130 6738706
SGTC_2926 9010726 65.15 µM -0.391248239835614 0.368060336056193 no 2133 0.347806877076328 3201 2994293
SGTC_1343 1487-0095 224 µM -0.391850777529625 0.367826299858768 no 2134 0.34758423706431 3240 4560101 YGL055W OLE1
SGTC_819 1013-0258 27.7 µM -0.392535952139776 0.367560225655428 no 2135 0.347331126262761 3107 5753198
SGTC_1474 0330-0125 5.35 µM -0.39278041504604 0.367465308629217 no 2136 0.347240835530273 3166 X1474
SGTC_1596 piperlongumine 63 µM -0.393000525626973 0.367379853748494 no 2137 0.347159546582389 3228 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1864 st057645 30.4 µM -0.393265196557826 0.367277107626618 no 2138 0.347061810381153 3196 688666
SGTC_736 0958-0254 92.6 µM -0.393916248930871 0.367024407414819 no 2139 0.346821436701154 3205 6812352
SGTC_1316 1272-0050 65.9 µM -0.394142742023097 0.366936509626752 no 2140 0.346737828109156 3097 7340392
SGTC_2669 eugenol 100 µM -0.394241296800543 0.366898264514624 no 2141 0.346701449523253 3155 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2803 7707263 71.43 µM -0.394510396225312 0.366793844670561 no 2142 0.346602126616156 3080 2199229
SGTC_155 k072-0202 43.6 µM -0.395285530570303 0.366493120959276 no 2143 0.346316088347711 3182 5857737
SGTC_2804 7954240 19.48 µM -0.395490907511991 0.366413455960184 no 2144 0.346240315306381 3215 828705
SGTC_1464 k208-0027 110 µM -0.396853626458914 0.3658850079882 no 2145 0.345737701357778 3292 X1464
SGTC_2892 9047358 58.44 µM -0.398301988555334 0.365323627343433 no 2146 0.34520379741253 3128 6466771
SGTC_1278 0874-0585 172 µM -0.399535050784776 0.364845923502472 no 2147 0.344749501219581 3170 766306
SGTC_2013 4024628 200 µM -0.400461271034596 0.364487232002964 no 2148 0.344408401717545 3247 5230760
SGTC_842 0271-0008 11.1 µM -0.401575491573134 0.364055892013811 no 2149 0.343998234910599 3238 1221709
SGTC_1751 st044839 27.194 µM -0.402652111815477 0.36363927148635 no 2150 0.343602083820316 3189 5291326
SGTC_276 colchicine 750 µM -0.402725094968992 0.36361103497032 no 2151 0.343575235290831 3250 2833 A microtubule depolymerizer.
SGTC_2805 7950783 58.44 µM -0.402754552336546 0.363599638393497 no 2152 0.343564398945046 3217 1178958 YDL195W SEC31
SGTC_3102 9121669 49.47 µM -0.403570692931008 0.363283934889541 no 2153 0.34326422022503 3122 41905072
SGTC_429 1112-0049 25.5 µM -0.406021069880751 0.362336626712144 no 2154 0.342363559571466 3059 2836170
SGTC_98 0074-0023 107.663 µM -0.406024989532147 0.362335112060295 no 2155 0.342362119580505 3189 3563821
SGTC_3018 9082602 49.47 µM -0.406234065390511 0.362254323015865 no 2156 0.342285313177163 3206 17332089
SGTC_3257 9139206 32.98 µM -0.406242379239852 0.362251110586479 no 2157 0.342282259124533 3225 4910041
SGTC_1646 st011709 75.6 µM -0.406372787968392 0.362200722582235 no 2158 0.342234355454321 3218 5757843
SGTC_1294 1000-1494 117 µM -0.407079836886741 0.361927570923294 no 2159 0.341974675959663 3144 712797 YDL207W GLE1
SGTC_3108 9121785 49.47 µM -0.407263404853352 0.361856665265227 no 2160 0.341907268742594 3179 17140271
SGTC_499 genistein 192 µM -0.407422707289331 0.361795136345904 no 2161 0.341848776052439 3196 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2187 6125751 200 µM -0.408392321640499 0.361420709925909 no 2162 0.341492834841184 3154 874498
SGTC_3226 9131256 49.47 µM -0.408648348117295 0.361321864832888 no 2163 0.341398872141032 3177 17178073
SGTC_2622 2-methoxyxanthone 59.94 µM -0.410157163335194 0.360739539152376 no 2164 0.340845331000386 3135 71034 A hepatoprotective.
SGTC_1128 3448-9350 235 µM -0.410252537765805 0.360702740320414 no 2165 0.340810352346853 3180 619386
SGTC_2725 haloperidol 53.21 µM -0.411097067759626 0.360376947059624 no 2166 0.340500679998553 3096 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1741 st038134 10.228 µM -0.41153362032828 0.360208578450591 no 2167 0.340340646988898 3344 1272587
SGTC_1825 st052143 62.6 µM -0.41248916348859 0.359840141373014 no 2168 0.339990460907362 3284 674173
SGTC_219 mitoxanthrone 164.414 µM -0.412586393254664 0.359802658939998 no 2169 0.339954836013578 3152 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1762 st045503 25.4615 µM -0.412763306664776 0.359734461627488 no 2170 0.339890018774425 3196 4645554
SGTC_1420 4'-methoxyflavone 42 µM -0.413482544733718 0.359457252769139 no 2171 0.339626554286781 3216 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_3148 9097893 49.47 µM -0.413715313910455 0.359367554665228 no 2172 0.339541305257232 3099 17174100
SGTC_1401 3807-4679 7.6 µM -0.414294197918897 0.359144514075388 no 2173 0.339329331259927 3187 3291456
SGTC_1553 gossypol 38.6 µM -0.41484973806482 0.358930512870984 no 2174 0.339125953044819 3131 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1143 3454-2408 5.08 µM -0.41774966065611 0.357814145436008 no 2175 0.338065079676497 3217 X1143
SGTC_1415 3966-0071 78.1 µM -0.417929328800876 0.357745019443266 no 2176 0.33799939418621 3209 2893185
SGTC_2249 haloperidol 116.36 µM -0.419597412093805 0.357103459703445 no 2177 0.337389789611704 3154 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_482 fipronil 114 µM -0.419895648890012 0.356988797668926 no 2178 0.337280843248772 3205 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2374 9071832 200 µM -0.420138598885004 0.35689540109957 no 2179 0.337192103322703 3250 17381698
SGTC_2103 5378138 10 µM -0.420252455892282 0.356851634328219 no 2180 0.337150519023847 3236 244142
SGTC_152 4469-0003 551.229 µM -0.421513304761258 0.356367088578193 no 2181 0.336690148942148 3278 697280
SGTC_1331 1472-0049 76.2 µM -0.421587409948945 0.356338617069086 no 2182 0.336663098735254 3097 24051409
SGTC_2799 7812892 81.82 µM -0.422390234419579 0.356030220060014 no 2183 0.336370102353564 3277 20205235
SGTC_396 dithiazanine 1.25 µM -0.425184668104246 0.354957501741179 no 2184 0.335351029989275 3150 10578 An antihelmenthic.
SGTC_924 2046-0044 21.3 µM -0.426425511596078 0.354481538463954 no 2185 0.33489890752143 3156 3623589
SGTC_420 mitomycin C 81.9 mM -0.427025379245662 0.354251522376708 no 2186 0.334680421246301 3146 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_172 1112-0046 2.638 µM -0.427157230834137 0.354200971704007 no 2187 0.334632405215264 3136 2802135 YIL048W NEO1
SGTC_834 0312-0008 75.7 µM -0.427222547612617 0.354175930810135 no 2188 0.334608619984931 3187 6385573 YIL048W NEO1
SGTC_2830 7992007 71.43 µM -0.428307040571818 0.353760254317658 no 2189 0.33421379684988 3049 1952075
SGTC_290 2043-6722 48.1 µM -0.429073101284572 0.353466735073616 no 2190 0.333935013408557 3250 773758 YLR208W SEC13
SGTC_2870 9038528 12.99 µM -0.431336515532938 0.352600008336429 no 2191 0.333111851520714 3266 6463316
SGTC_1865 st057639 52.2 µM -0.431936790499968 0.35237027380245 no 2192 0.332893677242864 3164 688818
SGTC_2446 5162541 200 µM -0.432664544604407 0.352091823250928 no 2193 0.332629245610852 3124 1549321
SGTC_1387 3342-1166 1.8 µM -0.433479189896752 0.351780220772372 no 2194 0.332333340563285 3204 3418228
SGTC_2099 5377090 177.372 µM -0.434662489157521 0.351327785194207 no 2195 0.33190371481699 3251 2243829
SGTC_2367 9070478 135.38 µM -0.436818159899863 0.350504104111154 no 2196 0.331121613965615 3189 572802
SGTC_214 4373-3496 70 µM -0.4368564133831 0.350489493799641 no 2197 0.331107741823283 3281 3779166
SGTC_1711 st032263 62.8 µM -0.437021889065274 0.350426295534081 no 2198 0.331047736828601 3199 3958979
SGTC_2315 7733312 200 µM -0.438368484534391 0.349912159556271 no 2199 0.330559594178527 3141 726316
SGTC_888 0916-0002 6.97 µM -0.43992521241945 0.349318136924542 no 2200 0.329995637297869 3325 2802138 YIL048W NEO1
SGTC_2537 larixol 68.93 µM -0.439942600342646 0.349311504049884 no 2201 0.32998934034124 3271 6708759
SGTC_2052 5265182 7.135 µM -0.440268345936863 0.349187252192954 no 2202 0.329871381974219 3298 1239884
SGTC_2693 st077581 40.7 µM -0.440430362644605 0.349125458827962 no 2203 0.329812719094554 3292 25238761
SGTC_481 bay k-8644 50 µM -0.441309622152167 0.348790178001562 no 2204 0.32949443054805 3205 2303 A calcium channel antagonist.
SGTC_857 0438-0306 1.35 µM -0.443678827579005 0.34788733651615 no 2205 0.328637402518918 3278 4686136
SGTC_225 nsc-122657 1.016 µM -0.444806541232578 0.347457897073186 no 2206 0.328229783406836 3269 275685
SGTC_1513 0337-0559 19 µM -0.445638628062401 0.347141159364619 no 2207 0.327929151484563 3173 775073
SGTC_956 1185-0240 191 µM -0.44579973178948 0.347079846812203 no 2208 0.327870957784801 3174 1416193
SGTC_592 k241-0073 46.5 µM -0.447503027428604 0.346431854931957 no 2209 0.327255951241548 3311 4230158
SGTC_635 k038-0028 24.7 µM -0.448637819399341 0.34600039046296 no 2210 0.326846473519433 3197 4035102
SGTC_761 k216-0224 480 µM -0.449053388351557 0.345842435050133 no 2211 0.326696571957708 3352 1340404
SGTC_2941 9056145 11.23 µM -0.449779813511697 0.345566389392872 no 2212 0.326434607386009 3245 2119517
SGTC_1653 st012112 65 µM -0.44984987100866 0.345539771487586 no 2213 0.326409347665291 3325 720429
SGTC_1259 0671-0132 43 µM -0.451312695718661 0.34498415507762 no 2214 0.325882097977258 3171 X1259
SGTC_1987 st072290 61.9 µM -0.452649872461589 0.344476555026195 no 2215 0.325400440309447 3229 54697379
SGTC_758 0868-0029 16 µM -0.453196833931791 0.344269005901128 no 2216 0.32520350603585 3293 762687
SGTC_625 k213-0058 121 µM -0.453249725543385 0.344248938220331 no 2217 0.325184464921559 3272 3655420
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.453797375131627 0.34404117950624 no 2218 0.3249873365209 3147 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_3084 9116877 49.47 µM -0.454232177167783 0.343876264645289 no 2219 0.324830862876365 3245 27241325
SGTC_250 brefeldin a 552.239 µM -0.454316312435212 0.343844356641047 no 2220 0.324800588407306 3208 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1817 st052116 64.4 µM -0.454644542923305 0.343719887017875 no 2221 0.324682491999894 3322 4361398
SGTC_1432 4049-0298 68.4 µM -0.455284043696147 0.343477427982217 no 2222 0.32445245204087 3290 741646
SGTC_327 1273-0057 3.96 µM -0.456178509341672 0.343138410111423 no 2223 0.324130808975507 3226 3108138
SGTC_3238 9133470 49.47 µM -0.45693669659861 0.342851142915207 no 2224 0.323858273328196 3320 3534688
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.457177960454972 0.342759750250599 no 2225 0.323771569161764 3376 16725076
SGTC_3136 9095672 49.47 µM -0.458986867247442 0.342074815450298 no 2226 0.323121798436792 3226 17217380
SGTC_1342 1486-1464 234 µM -0.461749944762384 0.341029591020595 no 2227 0.322130325095208 3219 3253938
SGTC_723 4182-0001 115 µM -0.461849113303333 0.340992099887848 no 2228 0.322094763975414 3224 744821 YLR208W SEC13
SGTC_1486 3970-0793 4.53 µM -0.461927447529122 0.340962486375723 no 2229 0.322066675041349 3309 2844330
SGTC_709 3807-1509 243 µM -0.46193324451795 0.340960294917937 no 2230 0.322064596408778 3271 1886677 YPL242C IQG1
SGTC_162 k030-0015 37.8 µM -0.462852308346818 0.340612925621683 no 2231 0.321735117127094 3269 1809920 YMR134W ERG29
SGTC_968 1309-0633 340 µM -0.463347475695317 0.34042582820796 no 2232 0.321557660453448 3311 3761976
SGTC_685 1278-0033 54.9 µM -0.465824960602676 0.339490308921653 no 2233 0.320670398500356 3347 3590572
SGTC_554 4483-2211 187 µM -0.466105132007852 0.339384575917307 no 2234 0.320570125012731 3274 747107
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.466528440656976 0.339224848783544 no 2235 0.320418647471953 3268 676296 Flavone; oxidizing agent.
SGTC_2144 5628481 200 µM -0.468440036524878 0.338503906081204 no 2236 0.319734971352263 3227 2818399
SGTC_2468 5987765 72.9 µM -0.468806911663056 0.338365609703297 no 2237 0.319603829569459 3247 26772094
SGTC_1245 0418-0076 17.2 µM -0.469690830944168 0.338032499161615 no 2238 0.319287959821912 3341 6790114
SGTC_2868 9035608 32.47 µM -0.470822092302755 0.337606361178439 no 2239 0.318883893353129 3227 6462614
SGTC_1745 st081495 74 µM -0.471866520130988 0.337213117521779 no 2240 0.318511033289172 3310 13842402 YBL026W LSM2
SGTC_1934 st074720 32.6 µM -0.472280747111097 0.337057203702382 no 2241 0.318363205384904 3202 17250992
SGTC_2037 5169046 200 µM -0.472453506439255 0.336992185867229 no 2242 0.318301560172198 3319 5718022
SGTC_504 lovastatin 124 µM -0.474921879433933 0.336063748343597 no 2243 0.317421327950775 3269 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1467 k284-1082 293 µM -0.475288806373488 0.335925820043134 no 2244 0.317290568200445 3313 3334705
SGTC_3324 9138759 60.749 µM -0.475484396160318 0.33585230662109 no 2245 0.317220876251785 3340 45595710
SGTC_1980 st071811 45.7 µM -0.476426948441131 0.335498131619879 no 2246 0.316885119842288 3382 4974850
SGTC_1425 4048-4433 7.33 µM -0.476592646995059 0.335435883551038 no 2247 0.316826110199384 3342 23734946
SGTC_2078 5212016 200 µM -0.477146406612798 0.335227885146262 no 2248 0.316628935551454 3281 1899708
SGTC_654 1124-0271 80.9 µM -0.477332185260694 0.335158115886716 no 2249 0.316562797867287 3245 5403748
SGTC_423 5-fluorouracil 457 µM -0.477646809776287 0.335039971471575 no 2250 0.316450804094759 3135 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_49 0717-0965 32.132 µM -0.478704256319143 0.334643010176605 no 2251 0.316074518705374 3475 5889349 YGL099W LSG1
SGTC_2219 9098279 200 µM -0.48063182612834 0.333919883584039 no 2252 0.315389095849961 3326 902349
SGTC_2015 5119600 184 µM -0.480816999336932 0.333850448375326 no 2253 0.315323283656316 3377 2828786
SGTC_2193 5925765 200 µM -0.482298847367931 0.333294998413352 no 2254 0.314796832984114 3332 877370
SGTC_565 1418-0001 44.5 µM -0.4824841654879 0.333225560194312 no 2255 0.314731022141991 3380 2862145
SGTC_1888 azatryptophan 97.5 µM -0.482633343339435 0.333169667792685 no 2256 0.314678049837566 3318 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1020 4335-0961 93.3 µM -0.483022867267563 0.333023742500153 no 2257 0.314539749833417 3176 669075
SGTC_2399 5884133 200 µM -0.483394039885734 0.332884715583526 no 2258 0.314407989648398 3252 722445
SGTC_2576 guaiol 23.12 µM -0.483490085363474 0.332848744400187 no 2259 0.314373898930041 3271 227829
SGTC_2524 avocatin b 10.57 µM -0.483929816347103 0.332684074943725 no 2260 0.314217839492988 3289 6710748
SGTC_3182 9108849 49.47 µM -0.484127756052117 0.332609961466126 no 2261 0.314147602018249 3349 17133045
SGTC_38 0929-0051 58.268 µM -0.485172867435408 0.332218754664038 no 2262 0.313776863424486 3323 1379719
SGTC_2649 anisomycin 9.56 µM -0.485668633331614 0.332033243120001 no 2263 0.313601063133868 3328 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2438 5259590 200 µM -0.486187256211151 0.331839222732041 no 2264 0.313417202974634 3310 1201127
SGTC_1139 k015-0024 46.9 µM -0.486497174571685 0.331723301660801 no 2265 0.31330735405123 3350 2766652
SGTC_1319 1306-0155 43.7 µM -0.487579282698815 0.331318679098684 no 2266 0.312923936465051 3288 3122360
SGTC_3318 9139014 38.6185 µM -0.488867545013245 0.330837227901773 no 2267 0.312467737103932 3284 16643984
SGTC_539 4859-0462 2.54 µM -0.488935741587344 0.330811749170079 no 2268 0.312443595337472 3358 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1340 1486-1359 257 µM -0.489166810723774 0.330725425902283 no 2269 0.31236180224079 3254 4309068
SGTC_1885 st057546 99.9 µM -0.490558891105413 0.330205560357715 no 2270 0.311869233914916 3424 702008
SGTC_1396 3511-0007 98.6 µM -0.490943265177635 0.330062075434126 no 2271 0.311733287693522 3333 X1396
SGTC_2770 toltrazuril 17.5 µM -0.491294578673592 0.329930953719015 no 2272 0.311609056841966 3367 68591 Kills coccidiodes.
SGTC_1516 st013856 110 µM -0.492396677368746 0.329519749989151 no 2273 0.31121947385095 3330 5281404 A mutagen and neurotoxin.
SGTC_1138 3761-0006 1.03 µM -0.492917602646456 0.329325459389159 no 2274 0.311035404509928 3356 12061087
SGTC_103 0844-0104 51.839 µM -0.493024674984477 0.329285530100415 no 2275 0.310997576272074 3376 5375804
SGTC_1811 st050069 61.5 µM -0.493480108627191 0.329115712087284 no 2276 0.310836695663984 3364 3877702
SGTC_2409 alverine citrate 63.97 µM -0.493850894515076 0.328977482804308 no 2277 0.310705743326218 3441 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1663 st014140 55.4 µM -0.494857429774032 0.328602363581994 no 2278 0.310350381076194 3373 4207120
SGTC_2442 5158906 48.48 µM -0.497503801772938 0.327616928555354 no 2279 0.309416911315443 3361 1893835
SGTC_2589 lobaric acid 100 µM -0.497824814300737 0.327497473901956 no 2280 0.30930376217996 3261 73157 A novel microtubule depolymerizer.
SGTC_711 k292-0785 179 µM -0.498498240462361 0.327246937055393 no 2281 0.309066454540797 3297 4146315
SGTC_213 1246-0773 967 nM -0.499145428152427 0.32700623510558 no 2282 0.308838468092985 3319 6251622
SGTC_3310 9130229 44.1445 µM -0.499325370284168 0.326939323833643 no 2283 0.308775092502275 3362 7761258
SGTC_1120 ficusin 1.78878 µM -0.50041188040712 0.32653542459415 no 2284 0.308392544850513 3374 6199 A DNA cross-linker.
SGTC_282 k297-0036 65.7 µM -0.500780401937849 0.326398476550873 no 2285 0.308262839887978 3374 5061378
SGTC_1640 st009078 66.4 µM -0.502840204087894 0.325633454968544 no 2286 0.307538312359233 3366 690618
SGTC_1384 3089-0840 101 µM -0.50434937426288 0.325073406626579 no 2287 0.307007943478474 3375 1069836
SGTC_2175 5807670 165.306 µM -0.509669301837292 0.323102355241893 no 2288 0.305141581545252 3370 241186
SGTC_3335 9143315 29.6265 µM -0.509919273074582 0.32300986154791 no 2289 0.305054009465967 3293 4899691
SGTC_63 0099-0242 26.702 µM -0.512172403489816 0.322176658672693 no 2290 0.304265177592505 3406 3898502 YLR359W ADE13
SGTC_1821 st053465 65.6 µM -0.512720487072593 0.321974113366658 no 2291 0.304073428333366 3334 675086
SGTC_1769 st044406 64.4 µM -0.513709064328602 0.321608916526676 no 2292 0.30372770683665 3283 670903
SGTC_359 0081-0058 15.9 µM -0.513714590823189 0.321606875431927 no 2293 0.303725774625018 3583 3494159
SGTC_3344 9148862 3.898 µM -0.5144828719166 0.321323179372586 no 2294 0.303457216231953 3436 4905352
SGTC_2720 fluspirilene 36.88 µM -0.516637631390472 0.320528067697953 no 2295 0.302704570590411 3369 3396 An atypical antipsychotic.
SGTC_158 k038-0087 26.446 µM -0.518158689204068 0.319967288758492 no 2296 0.302173777508073 3275 X158
SGTC_1349 flufenamic acid 69 µM -0.51823967739707 0.319937441796388 no 2297 0.302145527333181 3334 3371 A non-steroidal anti-inflammatory.
SGTC_1218 1348-1416 30.7 µM -0.522789136451865 0.318262684646723 no 2298 0.300560500160259 3366 6787668
SGTC_1031 k035-0009 16 µM -0.523080771098338 0.318155453557922 no 2299 0.300459023097586 3437 5180959
SGTC_3046 9092212 49.47 µM -0.52313369152361 0.31813599688995 no 2300 0.300440610588886 3375 25236637
SGTC_1958 st076513 41.9 µM -0.523255344199313 0.318091272097828 no 2301 0.300398286124266 3298 732122 YGL099W LSG1
SGTC_2741 miltefosine 3.04 µM -0.523370702061547 0.318048864001901 no 2302 0.300358154191393 3300 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_3068 9116768 49.47 µM -0.524031088775395 0.31780613720405 no 2303 0.30012845841244 3395 41904888
SGTC_6 0844-0013 19.835 µM -0.524537258347985 0.31762014628441 no 2304 0.299952456255805 3456 1584900
SGTC_971 1315-0384 26.7 µM -0.524777808618138 0.317531772734923 no 2305 0.299868829978499 3341 6769120
SGTC_756 0508-1999 28.3 µM -0.525280506750598 0.317347124669087 no 2306 0.299694103196772 3302 6753853
SGTC_2351 9026858 72.31 µM -0.525466066621523 0.31727897741123 no 2307 0.299629618334368 3287 1409300
SGTC_524 r073-0010 27.8 µM -0.528504338318672 0.31616404810267 no 2308 0.298574668389429 3315 2772106
SGTC_106 0092-0003 11.579 µM -0.529446014394728 0.315818827494425 no 2309 0.298248042509213 3350 1072148
SGTC_2404 5161160 200 µM -0.530877832868031 0.315294227361648 no 2310 0.297751719894695 3371 2831543
SGTC_2634 4'-methoxyflavone 100 µM -0.531486607155092 0.315071292881524 no 2311 0.297540809842327 3351 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2850 9015429 58.44 µM -0.532119369175739 0.314839645415598 no 2312 0.29732166154828 3356 6457570
SGTC_1756 st041558 35.5 µM -0.535409792753595 0.313636231976408 no 2313 0.296183259993201 3488 3955792
SGTC_2902 5787006 60.46 µM -0.535479128663325 0.313610894873641 no 2314 0.296159293085542 3292 591003
SGTC_2674 ligustilide 100 µM -0.536723068265274 0.313156477229512 no 2315 0.295729459575572 3395 5319022 A signalling regulator.
SGTC_270 tamoxifen 5.46 µM -0.539065328418054 0.312301607485091 no 2316 0.294920889103261 3525 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_403 arphamenine a 50 µM -0.542028012045449 0.311221743870798 no 2317 0.293899604402783 3399 5487158 An arginine aminopeptidase inhibitor.
SGTC_2931 9014674 55.67 µM -0.542053673308098 0.311212397715601 no 2318 0.293890765702013 3319 2996810
SGTC_1358 1509-0022 2.48 µM -0.542351050289722 0.311104098151034 no 2319 0.293788346891112 3415 3258434
SGTC_1660 st012960 28.1 µM -0.542807102426392 0.310938043605637 no 2320 0.293631311284803 3391 24207266
SGTC_3205 9113483 49.47 µM -0.543408001460192 0.310719307181475 no 2321 0.293424458889423 3457 17018033
SGTC_2914 7968218 45.32 µM -0.543478007258989 0.310693828350351 no 2322 0.293400364611162 3391 2977111
SGTC_2782 7736369 71.43 µM -0.543492915871742 0.310688402431004 no 2323 0.29339523355085 3374 2950836 YOL077C BRX1
SGTC_894 0960-0238 55.9 µM -0.545870024348155 0.309823792343584 no 2324 0.292577642354735 3453 6741907 YDL195W SEC31
SGTC_2514 salinomycin 42.74 µM -0.546276322053405 0.309676117376974 no 2325 0.292438004871089 3471 23682228 A polyether potassium ionophore.
SGTC_126 0417-1624 672.48 µM -0.547625666476293 0.309185898501813 no 2326 0.291974481012106 3515 41912 YDL195W SEC31
SGTC_1895 st058434 18.3 µM -0.547940877114263 0.309071430888529 no 2327 0.291866249851606 3485 5393175
SGTC_2353 9059630 146.67 µM -0.549293979144591 0.308580267407055 no 2328 0.291401859298246 3414 4779114
SGTC_704 1310-0270 142 µM -0.553904898518203 0.306909121163154 no 2329 0.289821966260022 3419 5718033
SGTC_3275 9138069 49.47 µM -0.555045341909004 0.306496403953989 no 2330 0.289431823585291 3439 17617007
SGTC_656 4090-1979 187 µM -0.55535894925297 0.306382954982542 no 2331 0.289324582604488 3491 22330961
SGTC_2897 9048598 12.99 µM -0.557450012050575 0.305626977721925 no 2332 0.288610001788608 3363 6467404
SGTC_55 0767-0285 6.563 µM -0.558931239225339 0.305091973594263 no 2333 0.288104324239256 3438 3116166
SGTC_2428 5615643 7.78 µM -0.559353220530415 0.304939634392639 no 2334 0.28796034019965 3442 2253075
SGTC_1231 0242-0792 125 µM -0.560636838705329 0.304476444094935 no 2335 0.287522566429017 3414 3707635
SGTC_1206 3978-0017 132 µM -0.562031112457031 0.303973679085481 no 2336 0.287047410773661 3534 3873677
SGTC_2519 cryptotanshinone 88.04 µM -0.562510594012068 0.303800867084069 no 2337 0.286884093849911 3478 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_626 0214-0009 33 µM -0.563973268411821 0.303273969352642 no 2338 0.286386162363991 3480 3437874
SGTC_642 0335-0876 158 µM -0.564632766206853 0.303036532817398 no 2339 0.286161786830811 3452 6812350
SGTC_3130 9127414 49.47 µM -0.565297553639166 0.302797276085816 no 2340 0.28593569619163 3457 1494646
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.566264574779756 0.302449396676008 no 2341 0.285606969167903 3419 1241132 A phosphatase inhibitor.
SGTC_318 1488-0629 67.2 µM -0.566890372254394 0.302224365765117 no 2342 0.28539433285934 3463 3662576
SGTC_641 4092-0595 30 µM -0.566990559400729 0.302188346384244 no 2343 0.28536029781802 3484 786260
SGTC_2226 7298446 200 µM -0.567171393570792 0.302123337584496 no 2344 0.285298870695484 3465 3283010
SGTC_373 0844-0104 25.9 µM -0.56814132656386 0.301774759694661 no 2345 0.284969504048601 3475 5375804
SGTC_2565 isoliquiritigenin 100 µM -0.568388171605876 0.301686076533483 no 2346 0.284885710180479 3432 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1239 0337-0584 35.4 µM -0.569179916274051 0.301401708285215 no 2347 0.284617024356622 3535 914301 YML130C ERO1
SGTC_1180 1193-0155 285 µM -0.56934759292671 0.301341499916188 no 2348 0.284560137274188 3476 2921347
SGTC_1664 st014217 9.02 µM -0.569855272236341 0.301159238374593 no 2349 0.284387931774113 3526 3982782
SGTC_1793 st048256 72.231 µM -0.571045542930528 0.300732115106283 no 2350 0.283984385716054 3444 672022
SGTC_2265 7929201 200 µM -0.572436936095555 0.300233166796212 no 2351 0.283512999291851 3413 1265108
SGTC_815 1582-0027 36.9 µM -0.572925804084652 0.300057949477001 no 2352 0.28334746605917 3485 3128206
SGTC_2488 5268135 45.7 µM -0.573745343241419 0.299764318679105 no 2353 0.283070069865502 3451 1270356 YLR208W SEC13
SGTC_3224 9130643 49.47 µM -0.574532743900442 0.299482325344247 no 2354 0.282803674685806 3545 17644395
SGTC_3247 9135149 49.47 µM -0.574730930861954 0.299411367208724 no 2355 0.282736642598037 3441 8934436 YOR116C RPO31
SGTC_2717 st081029 62.2815 µM -0.575972598516335 0.298966978666864 no 2356 0.282316851486163 3475 5292846
SGTC_3296 9122258 64.045 µM -0.577134151728638 0.298551534206138 no 2357 0.281924417671996 3465 4730474
SGTC_2035 5154463 94.595 µM -0.577834372746647 0.298301218076582 no 2358 0.281687973187661 3496 2769623
SGTC_151 3013-0144 2.285 µM -0.57784957132688 0.298295785923444 no 2359 0.281682842124856 3480 906558 YHR107C CDC12
SGTC_1097 itavastatin 7.23 µM -0.578083978753978 0.298212011628604 no 2360 0.28160371154389 3493 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1023 4482-3888 16 µM -0.578114571303483 0.298201079022951 no 2361 0.281593384990468 3524 3303168
SGTC_846 0335-0850 148 µM -0.578366244810518 0.298111147477924 no 2362 0.281508439214701 3479 6819598
SGTC_612 0302-0167 22.4 µM -0.578754817545135 0.297972321432134 no 2363 0.281377310985951 3477 235821
SGTC_1263 0774-1208 64.8 µM -0.57875927612306 0.297970728679385 no 2364 0.281375806559889 3553 906585
SGTC_283 0987-0079 11.7 µM -0.578926277288141 0.297911073088145 no 2365 0.281319459347207 3504 411556
SGTC_2303 7774051 200 µM -0.579740825026848 0.297620181183031 no 2366 0.281044704068995 3515 2953184
SGTC_206 4546-0025 72.014 µM -0.579905452554821 0.297561405027033 no 2367 0.280989189274883 3496 6620745 YIL048W NEO1
SGTC_823 0417-1665 178 µM -0.581958314536734 0.296828927257524 no 2368 0.280297379787097 3484 3429856
SGTC_3013 9080133 71.4286 µM -0.58218197184636 0.296749174397654 no 2369 0.280222057681987 3573 17050193
SGTC_546 peri-Naphthalide 147 µM -0.583158307202878 0.296401142719379 no 2370 0.27989336759394 3401 223824 A penicillin ester.
SGTC_2324 6149169 200 µM -0.583382693168122 0.296321182899029 no 2371 0.279817852930478 3393 2888231
SGTC_624 k048-0052 28 µM -0.584397483270127 0.295959686559998 no 2372 0.279476459797796 3441 6835531
SGTC_3147 9097027 49.47 µM -0.585241797881034 0.295659072715204 no 2373 0.279192571844938 3447 25236841
SGTC_1329 1447-1697 50.6 µM -0.586124316680733 0.2953450065614 no 2374 0.278895988221155 3482 2840515
SGTC_198 3454-2873 16.191 µM -0.587351880193362 0.294908403164574 no 2375 0.278483702244225 3439 710957
SGTC_738 1315-0003 72.4 µM -0.590740082664862 0.293704878760039 no 2376 0.277347293453358 3524 6251474
SGTC_2491 paeonol 100 µM -0.59211322868747 0.293217771294183 no 2377 0.276887384554339 3484 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2205 7238770 200 µM -0.592155615211976 0.293202741131914 no 2378 0.276873193945828 3520 279867
SGTC_2740 felodipine 17.08 µM -0.592760111727996 0.292988426967182 no 2379 0.276670852984149 3474 3333 L-type calcium channel blocker
SGTC_1142 3253-1408 9.78 µM -0.592769080873518 0.292985247653408 no 2380 0.276667851319717 3507 256655
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.595194073281602 0.292126242849059 no 2381 0.275856875754918 3475 688761
SGTC_363 0455-0021 3.06 µM -0.595266198749807 0.29210071181033 no 2382 0.275832773166797 3525 4597466
SGTC_892 0929-0076 29 µM -0.595686933886899 0.291951800307168 no 2383 0.275692194280549 3479 5751038
SGTC_1115 galangin 695.678 nM -0.596149322352986 0.291788187155823 no 2384 0.275537738533753 3570 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2490 carminic acid 95.39 µM -0.596326737028659 0.291725421469397 no 2385 0.275478486425315 3486 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2858 9025781 8.96 µM -0.597253472991503 0.291397663545624 no 2386 0.275169081479156 3554 4894980 YPL153C RAD53
SGTC_227 fluconazole 33.516 µM -0.598062232010463 0.291111770897429 no 2387 0.274899204831943 3473 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1856 st057054 55.7 µM -0.598160086943928 0.291077188507613 no 2388 0.274866560243477 3604 1266018
SGTC_3303 9125618 40.5795 µM -0.600838109519674 0.290131508566094 no 2389 0.273973909278959 3493 22695467
SGTC_1706 st031321 9.9705 µM -0.602221915406616 0.289643415311554 no 2390 0.273513214790174 3522 6103185
SGTC_2432 5630864 12.22 µM -0.602530128542497 0.289534755495943 no 2391 0.273410657192261 3511 5714970
SGTC_1257 0669-0121 16 µM -0.604249883181641 0.288928811709105 no 2392 0.272838760397241 3536 4307855
SGTC_897 1000-0139 31.4 µM -0.604794621964772 0.288737001243211 no 2393 0.272657733746013 3536 6151020
SGTC_694 1315-0438 43.2 µM -0.604961387148955 0.288678292780758 no 2394 0.272602326548403 3451 6793154
SGTC_1185 1319-0113 81.3 µM -0.606188667531968 0.288246410728743 no 2395 0.272194738573056 3524 4672763
SGTC_523 1934-0222 13.7 µM -0.606301282886222 0.28820679646396 no 2396 0.272157353442415 3515 1361595
SGTC_3061 glucosamine 200 µM -0.606426179457914 0.288162865086904 no 2397 0.27211589427822 3481 91431 and experimental redox chemotherapeutic
SGTC_2109 5483026 200 µM -0.607360500560897 0.28783432532027 no 2398 0.271805847912469 3517 759335
SGTC_265 mycophenolic acid 32.932 µM -0.607374875383837 0.287829272015221 no 2399 0.271801079125435 3629 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2525 harmine 47.85 µM -0.608568016453995 0.287409983037863 no 2400 0.271405404803617 3459 5280953 A monoamine oxidase inhibitor
SGTC_525 k781-2675 26.7 µM -0.608597550447499 0.287399607982331 no 2401 0.27139561426094 3561 3651118 YDL195W SEC31
SGTC_1612 st002233 45.4 µM -0.608880669409142 0.287300159547323 no 2402 0.271301769026695 3553 1035021
SGTC_1393 3470-5649 58.2 µM -0.609995117395837 0.286908856558629 no 2403 0.27093252097559 3449 4108395
SGTC_947 3447-0010 211 µM -0.610635098853562 0.286684261611957 no 2404 0.270720590474874 3555 748350
SGTC_2151 5563267 85.4165 µM -0.611326466401349 0.286441726957844 no 2405 0.270491736465783 3501 5310824
SGTC_391 gliotoxin 8.33 µM -0.611336328764755 0.286438267903651 no 2406 0.270488472561002 3579 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1908 st060353 56.5 µM -0.614939022813189 0.285176013200471 no 2407 0.269297495372524 3604 4227716
SGTC_70 0141-0289 43.283 µM -0.615758345466974 0.284889322367966 no 2408 0.269027011516421 3531 352408
SGTC_1953 st076800 12.1 µM -0.61595031172577 0.284822170955345 no 2409 0.268963657214607 3479 297591
SGTC_2628 lathosterol 100 µM -0.616572721782371 0.284604498636415 no 2410 0.268758295793056 3592 6710616
SGTC_3077 9117319 49.47 µM -0.616685195020624 0.284565172415586 no 2411 0.268721194154245 3543 17154678
SGTC_1119 parthenolide 318.541 nM -0.616918292553298 0.284483678223688 no 2412 0.268644310274297 3598 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_910 3454-3003 490 µM -0.617700485615021 0.284210293977434 no 2413 0.268386395911632 3527 820824
SGTC_2580 diallyl disulphide 81.36 µM -0.618167127654679 0.284047257792517 no 2414 0.268232588257922 3523 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2811 7967822 32.47 µM -0.619430069069958 0.283606233728301 no 2415 0.26781653873069 3545 2232244
SGTC_818 4072-2707 53.5 µM -0.621324166318802 0.282945423179959 no 2416 0.267193178164726 3509 882871
SGTC_2900 5328528 85.29 µM -0.622242181406165 0.282625413292951 no 2417 0.266891316722014 3565 795359
SGTC_3301 9125354 19.7965 µM -0.623252119096186 0.282273561290417 no 2418 0.266559428460989 3539 41905162
SGTC_1096 rimcazole 32.2 µM -0.624029326479804 0.282002933755817 no 2419 0.266304162804354 3491 18528119 A dopamine reuptake inhibitor.
SGTC_1548 st061468 90.8 µM -0.624960290676915 0.28167893190827 no 2420 0.265998560260327 3522 390799
SGTC_2910 7948405 25.97 µM -0.625118219943164 0.28162398587226 no 2421 0.265946735310943 3527 2971328
SGTC_779 1360-0071 233 µM -0.625909312885938 0.281348830211023 no 2422 0.265687212870089 3618 7566
SGTC_192 3455-0609 60.9 µM -0.625991607187905 0.281320214297644 no 2423 0.265660223142127 3609 3769639
SGTC_1221 2958-7315 257 µM -0.627130230011169 0.280924429180901 no 2424 0.265286936387679 3562 4562705
SGTC_2021 4019055 173 µM -0.627541465588186 0.280781549942576 no 2425 0.26515218216318 3598 44827708 YER133W GLC7
SGTC_2504 purpurogallin 52.29 µM -0.627854587792248 0.280672782676979 no 2426 0.265049601176494 3491 5281571 An antioxidant.
SGTC_3269 9137823 49.47 µM -0.629081597209429 0.280246760761221 no 2427 0.264647818845477 3492 17682936
SGTC_2155 5570423 76 µM -0.629696204438885 0.280033484815328 no 2428 0.264446683171444 3495 797402
SGTC_2471 5466956 24.79 µM -0.630393944793795 0.279791456098932 no 2429 0.264218435776617 3502 724419
SGTC_1304 1165-0502 251 µM -0.631902080990612 0.27926866827903 no 2430 0.263725431739263 3535 767425
SGTC_1279 0874-0590 65.2 µM -0.633655988842787 0.278661282616223 no 2431 0.263152676555377 3551 3523074
SGTC_1682 st012968 530 nM -0.636030025530412 0.277840169674609 no 2432 0.26237842600191 3485 24207270
SGTC_402 epigallocatechin gallate 10 µM -0.637718708066081 0.277256821414711 no 2433 0.261828402583728 3534 65064 An antioxidant.
SGTC_2467 5474540 200 µM -0.639671325976433 0.276583045502683 no 2434 0.261193150450892 3572 5413519
SGTC_1614 st002383 48.6 µM -0.64019338913824 0.27640303697397 no 2435 0.261023440072246 3590 1947235
SGTC_2972 9093619 59.92 µM -0.641417074831399 0.275981332768352 no 2436 0.260625871113243 3559 25236256
SGTC_493 zm226600 134 µM -0.642088999223314 0.275749909943342 no 2437 0.260407699101222 3616 5240098 A potassium channel opener. YCR052W RSC6
SGTC_3027 9089541 49.47 µM -0.642199569883991 0.275711836563294 no 2438 0.260371806125818 3579 9943819
SGTC_989 1501-0895 10.3 µM -0.642326589844517 0.275668102298293 no 2439 0.260330576594543 3580 2830112
SGTC_3003 9075612 71.4286 µM -0.643136884218849 0.275389189997772 no 2440 0.260067641552145 3581 6501993
SGTC_1288 0973-0013 65.5 µM -0.644830531625169 0.274806666594069 no 2441 0.259518506943806 3608 4315430
SGTC_2317 5986382 200 µM -0.644899443812836 0.274782977382907 no 2442 0.259496176094664 3631 877883
SGTC_2751 anetholtrithion 17.25 µM -0.645834711503727 0.274461569923216 no 2443 0.259193202728318 3562 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_3278 9139605 49.47 µM -0.646888836362885 0.2740995393825 no 2444 0.258851945730498 3627 7958859
SGTC_3159 9100096 49.47 µM -0.64849763646905 0.27354746538374 no 2445 0.258331569513403 3561 25236875
SGTC_1951 sophoraflavanone G 9.2 µM -0.649392276931089 0.27324069987509 no 2446 0.258042427319294 3596 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_643 k048-0106 28.4 µM -0.650524245475798 0.272852800739726 no 2447 0.257676822860137 3603 6763920
SGTC_508 roscovitine 141 µM -0.650981021748922 0.272696351579173 no 2448 0.257529368945739 3621 160355 A CDKinase inhibitor.
SGTC_2086 5274770 176.623 µM -0.652146982913751 0.272297203438173 no 2449 0.257153178819806 3582 689278
SGTC_2928 9011484 9.79 µM -0.652586466128227 0.272146828759226 no 2450 0.2570114564765 3587 2994751
SGTC_3092 9117248 49.47 µM -0.654227434398435 0.271585716024418 no 2451 0.256482644553039 3626 17141857
SGTC_2890 9046729 58.44 µM -0.654568290801377 0.271469235878321 no 2452 0.256372872665211 3523 903329
SGTC_2434 5670830 169.91 µM -0.654739539588091 0.271410724781968 no 2453 0.256317731695929 3586 1549830
SGTC_2142 5622915 118.518 µM -0.655898213713251 0.271015002206585 no 2454 0.255944808811295 3585 5322196
SGTC_130 0136-0219 337.655 µM -0.656221916801802 0.270904499181848 no 2455 0.255840674579007 3573 234244
SGTC_1153 4055-0057 267 µM -0.65633298826491 0.270866587726097 no 2456 0.255804948346428 3596 882706
SGTC_2009 4012297 12.05 µM -0.656340745539158 0.270863940074184 no 2457 0.255802453309721 3583 45595307
SGTC_919 tnp00227 403.569 nM -0.657559376819186 0.270448166881084 no 2458 0.255410652588425 3616 1269246 A methoxyflavone. YNL221C POP1
SGTC_1356 1502-0781 85.8 µM -0.658223302093489 0.270221782829998 no 2459 0.255197326792906 3583 567702
SGTC_1866 st057638 64 µM -0.658764065463906 0.270037464355627 no 2460 0.255023643013805 3600 688802
SGTC_2819 7996655 46.38 µM -0.658890002195302 0.269994548021253 no 2461 0.254983203208277 3498 6456960
SGTC_2352 9027995 87.8 µM -0.659260421391524 0.26986833748688 no 2462 0.254864276581262 3559 2997347
SGTC_1842 st055362 61.2 µM -0.659681557303397 0.269724882461363 no 2463 0.25472910214263 3609 676032
SGTC_852 0418-0143 439 µM -0.659751160038007 0.269701176781686 no 2464 0.25470676496415 3642 5369229
SGTC_1732 st034308 51.822 µM -0.663368996075588 0.268470433078669 no 2465 0.25354712873648 3544 830119
SGTC_1792 st045773 43.6 µM -0.663514284436159 0.268421066789465 no 2466 0.253500617007242 3568 2919270
SGTC_1433 4060-0023 7.6 µM -0.664739130070548 0.268005068501258 no 2467 0.253108680681405 3632 3840627
SGTC_2125 5246583 200 µM -0.667736112364425 0.266988564406061 no 2468 0.252151027073638 3654 835267
SGTC_1489 4065-0444 182 µM -0.667911679495022 0.266929076701979 no 2469 0.252094985793282 3601 2877968
SGTC_1370 2001-0092 44.6 µM -0.668475215408056 0.266738178134101 no 2470 0.251915148722007 3702 790957
SGTC_3117 9124945 49.47 µM -0.669107979333546 0.266523910751916 no 2471 0.251713300151708 3552 17592065
SGTC_303 1348-1668 34.2 µM -0.670360658275706 0.266099983808183 no 2472 0.251313953798863 3634 5380509
SGTC_1889 st059080 5.18 µM -0.670982996061031 0.26588950160531 no 2473 0.251115680948028 3635 176925 Isolated from Daphnopsis sellowiana.
SGTC_1941 st076221 61.8 µM -0.673384889768564 0.265077943873041 no 2474 0.25035122954337 3630 2828568
SGTC_521 r062-0005 13.8 µM -0.673638105949484 0.26499245994567 no 2475 0.250270710301092 3560 2832033
SGTC_3056 9094900 49.47 µM -0.674714685272508 0.264629171095459 no 2476 0.249928526324941 3577 25236784
SGTC_2763 lisinopril 49.32 µM -0.675365558473922 0.264409658595942 no 2477 0.249721770869076 3611 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_575 k072-0246 11.9 µM -0.675654891223705 0.264312108441222 no 2478 0.24962989101018 3654 6796779
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.67568176772754 0.264303047807849 no 2479 0.249621357079495 3675 688788
SGTC_1333 1482-0047 286 µM -0.677166812782067 0.263802653859609 no 2480 0.249150060820037 3621 3811116
SGTC_1872 amphotericin b 148 nM -0.677571644353095 0.263666327519652 no 2481 0.249021664974667 3651 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1974 st069448 26.9 µM -0.67789394723977 0.263557818274408 no 2482 0.248919468995064 3607 6323587 YNR016C ACC1
SGTC_3020 9089140 49.47 µM -0.67816897255338 0.26346524392309 no 2483 0.248832281468412 3644 17217859
SGTC_2204 7233102 200 µM -0.678613256951641 0.263315731523072 no 2484 0.2486914703926 3570 2172480
SGTC_1995 st072814 61.1 µM -0.678841389048595 0.263238976417452 no 2485 0.248619182915266 3610 5769371
SGTC_425 3825-7017 13.1 µM -0.679107841829976 0.263149342777993 no 2486 0.248534767059512 3684 3397440
SGTC_452 diindolylmethane 8 µM -0.679245308380765 0.263103105683873 no 2487 0.248491221763811 3606 3071 Inhibits expression of several cancer promoting factors.
SGTC_597 k018-0003 82.8 µM -0.679432511262364 0.263040146372003 no 2488 0.248431928023196 3716 6786234
SGTC_2991 9074669 71.4286 µM -0.680047106683566 0.262833502288164 no 2489 0.248237317050512 3650 17333109
SGTC_2008 4012253 172 µM -0.681028508140057 0.262503700020141 no 2490 0.247926725968136 3657 603940
SGTC_360 0957-0399 1.01 µM -0.681102352723542 0.262478892946358 no 2491 0.247903364241537 3644 6752301 YPR165W RHO1
SGTC_3 0833-0587 95.581 µM -0.681300409473051 0.262412364427566 no 2492 0.247840712128499 3589 5382644
SGTC_772 k072-0172 35.3 µM -0.681602594360839 0.262310875245497 no 2493 0.247745137018424 3587 5861980
SGTC_3228 9131799 49.47 µM -0.683321964264559 0.261733805518644 no 2494 0.247201709037876 3628 17015818
SGTC_1919 st067113 52.3 µM -0.68365830269808 0.261620996935403 no 2495 0.247095479736457 3657 1268243
SGTC_631 k072-0230 41.5 µM -0.683981205847952 0.261512718056526 no 2496 0.246993516821432 3653 5773147
SGTC_1861 st057647 17.4 µM -0.685402131059626 0.261036513767216 no 2497 0.246545099832838 3679 688668
SGTC_536 3852-0578 10.6 µM -0.686082478972112 0.260808662098832 no 2498 0.246330549469382 3665 2869208
SGTC_1782 st039423 80.636 µM -0.688821859978336 0.259892267216618 no 2499 0.245467688718844 3650 2068169
SGTC_3329 9141233 27.5565 µM -0.689089560809291 0.259802803430745 no 2500 0.245383454475058 3655 4909101 YNL103W MET4
SGTC_399 oxolinic acid 75 µM -0.689464932220059 0.259677383641733 no 2501 0.245265366976018 3644 4628 A DNA gyrase inhibitor.
SGTC_47 0149-0135 24.25 µM -0.690058166927421 0.259479234708926 no 2502 0.245078804517968 3625 5239155
SGTC_133 0724-0033 378.92 µM -0.691312964072081 0.259060371818667 no 2503 0.244684443271645 3561 280309
SGTC_1911 st060208 74.3 µM -0.691920529927932 0.258857686421777 no 2504 0.244493618578347 3682 688783
SGTC_2607 solasodine 47.35 µM -0.696199375824894 0.257432580562879 no 2505 0.243151989258981 3696 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_978 1416-0512 87.4 µM -0.696790701193804 0.257235955721701 no 2506 0.2429668931505 3708 6814003
SGTC_1455 4262-0120 131 µM -0.697022282162258 0.257158972743874 no 2507 0.242894424670791 3732 1529587
SGTC_1839 st053978 48 µM -0.697591957748188 0.256969650129953 no 2508 0.24271620624639 3711 3788398
SGTC_1327 1436-0082 2.18 µM -0.697695541442624 0.256935233530561 no 2509 0.242683808528212 3672 15992205
SGTC_2335 9018011 154.17 µM -0.698266025815846 0.256745728033977 no 2510 0.242505420939052 3702 6458208
SGTC_1086 cerivastatin 2.18 µM -0.700134972048964 0.25612540496602 no 2511 0.24192150866092 3629 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1313 1220-0047 237 µM -0.700149392812944 0.256120621602172 no 2512 0.241917006168835 3696 3528706
SGTC_2697 mebhydrolin 72.4 µM -0.701870358469639 0.255550112431662 no 2513 0.241380007926311 3672 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2959 9079155 11 µM -0.70202224150819 0.25549979430294 no 2514 0.241332646509605 3657 16189457
SGTC_603 3794-0023 45.9 µM -0.702392978082342 0.255376992779613 no 2515 0.241217061593066 3666 3802260
SGTC_2800 7887935 81.82 µM -0.703843303759905 0.254896888368265 no 2516 0.240765181312906 3665 2961002
SGTC_740 k014-0057 261 µM -0.703946592604025 0.254862714468742 no 2517 0.240733017024131 3699 4012779
SGTC_1759 st043059 70 µM -0.70477857950188 0.254587532755114 no 2518 0.240474020454 3675 669426
SGTC_486 niguldipine 82 µM -0.705861785492374 0.254229493067752 no 2519 0.240137047189015 3693 1236 A calcium channel blocker.
SGTC_2319 6033012 152.6 µM -0.705907236088012 0.254214475736689 no 2520 0.240122913645831 3661 847246
SGTC_1136 pergolide 1.05886 µM -0.708925222098786 0.253218344839313 no 2521 0.239185441149031 3682 47811 A dopamine receptor agonist.
SGTC_636 0kpi-0074 126 µM -0.709526874676412 0.253020006180717 no 2522 0.238998790099081 3705 616434
SGTC_3184 9108758 49.47 µM -0.709977645146288 0.252871460362737 no 2523 0.238858999497303 3695 902885
SGTC_2406 ethylparaben 405.7 µM -0.70997830111082 0.252871244231215 no 2524 0.238858796105572 3672 8434 A possible steroid mimic.
SGTC_2653 dihydrofissinolide 100 µM -0.710383925699739 0.252737614987764 no 2525 0.238733044204029 3739 6857746
SGTC_496 calpeptin 138 µM -0.711423921089604 0.252395168154686 no 2526 0.238410789960664 3655 73364 A calpain inhibitor.
SGTC_1526 st051518 75 µM -0.711583306139709 0.252342707902889 no 2527 0.23836142377231 3694 673993
SGTC_2682 pyrogallin 40.03 µM -0.712129973436949 0.252162820625553 no 2528 0.238192147537087 3726 822798 An ATP competetive kinase inhibitor.
SGTC_1469 k284-2957 126 µM -0.712405828377332 0.252072073008725 no 2529 0.238106753708522 3703 23884841
SGTC_2847 9005661 71.43 µM -0.713613301921636 0.251675054962312 no 2530 0.237733164958799 3621 2991449
SGTC_594 1487-1584 10.8 µM -0.714784205712327 0.25129037671047 no 2531 0.237371198081271 3684 5013332
SGTC_984 1492-0255 2.91 µM -0.717339555961239 0.250451945531905 no 2532 0.236582302789021 3656 1585198
SGTC_331 k048-0133 24.5 µM -0.717455661261537 0.250413885681478 no 2533 0.236546492711721 3670 6813582
SGTC_1347 1493-0251 600 nM -0.717973707949186 0.250244104959359 no 2534 0.236386749173052 3736 3986378
SGTC_2965 9082772 38.63 µM -0.71859670748894 0.250040008649991 no 2535 0.236194721321979 3703 16459634
SGTC_875 0709-0210 25.7 µM -0.719235317250534 0.249830890091478 no 2536 0.235997971121105 3709 6251364
SGTC_2951 9072950 58.06 µM -0.719458504194754 0.249757827403471 no 2537 0.235929230437789 3726 16488155
SGTC_1641 st009299 47.1 µM -0.719707626639491 0.249676287847514 no 2538 0.235852514759881 3643 4046054
SGTC_1067 clotrimazole 1.36 µM -0.720473168073975 0.24942580917149 no 2539 0.235616857206596 3730 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1546 5-methoxyflavanone 78.7 µM -0.720611880238347 0.249380438021825 no 2540 0.235574171175416 3727 147795
SGTC_64 000l-0018 272.079 µM -0.720990445520448 0.249256636009838 no 2541 0.235457696620134 3651 6811119
SGTC_2059 5238311 157 µM -0.721888053697636 0.248963222320475 no 2542 0.235181653302861 3717 703021
SGTC_2162 5663267 200 µM -0.72358424691539 0.248409266243565 no 2543 0.234660507750703 3698 6456493
SGTC_310 1273-0058 1.06 µM -0.724150972948814 0.248224326936778 no 2544 0.234486526889022 3703 2734232
SGTC_3209 9113616 49.47 µM -0.725646343177365 0.247736696493269 no 2545 0.234027801619263 3716 16649353
SGTC_757 1066-0008 322 µM -0.726469149026955 0.247468603210595 no 2546 0.233775606821663 3754 6842497
SGTC_1785 bathophenanthroline 24 µM -0.727098370462662 0.247263689831219 no 2547 0.233582848462175 3669 72812 An iron chelator.
SGTC_2963 9082507 9 µM -0.727554373096753 0.247115243912527 no 2548 0.23344320978303 3740 16459611
SGTC_2994 9053520 71.4286 µM -0.727734486757233 0.247056623312595 no 2549 0.233388067524941 3728 4647384
SGTC_1930 st074634 34.3 µM -0.7278188134103 0.247029180538848 no 2550 0.233362253188213 3665 684253 YOR116C RPO31
SGTC_2472 5377652 49.4 µM -0.728126899877681 0.246928932542558 no 2551 0.233267954271043 3767 1610903
SGTC_295 k015-0027 31 µM -0.728477576584473 0.246814852643501 no 2552 0.23316064509914 3684 3887424
SGTC_1781 st038725 66.3 µM -0.728534421134845 0.246796362996439 no 2553 0.23314325290788 3739 4270275 YIL048W NEO1
SGTC_1130 3454-2858 15.9 µM -0.729292606411826 0.246549821389657 no 2554 0.232911346984953 3755 715628 YIL048W NEO1
SGTC_317 4495-0002 170 µM -0.730474347807465 0.246165813885392 no 2555 0.23255014371189 3737 15991618
SGTC_2585 alliin 100 µM -0.730750378727361 0.246076163721864 no 2556 0.232465818816474 3775 87310 A garlic compound which reacts with lipids.
SGTC_966 1300-0360 30.2 µM -0.731318309958872 0.24589176438579 no 2557 0.232292374571289 3722 70588
SGTC_2814 7977482 42.97 µM -0.731578583556353 0.245807281972443 no 2558 0.232212911974835 3799 6456762
SGTC_1776 st049249 45.9 µM -0.731646986491083 0.245785081595511 no 2559 0.232192030788834 3759 1822314
SGTC_2119 5528445 120.635 µM -0.73345335759636 0.245199208184624 no 2560 0.231640982896654 3738 791935
SGTC_610 4215-0184 155 µM -0.733659804084836 0.245132297748564 no 2561 0.231578051192304 3764 5605015
SGTC_74 000s-0487 160.283 µM -0.733990236063959 0.245025223376338 no 2562 0.23147734445414 3670 677548
SGTC_651 3253-0966 34.4 µM -0.734494292031437 0.244861935735889 no 2563 0.231323768859466 3761 781462
SGTC_161 4065-0411 162.148 µM -0.734579142772422 0.244834454315713 no 2564 0.231297922155244 3766 1906281 YLR208W SEC13
SGTC_701 4424-0219 185 µM -0.737165707688612 0.243997516003243 no 2565 0.230510792317339 3746 2911779
SGTC_3091 9116372 49.47 µM -0.737345030631023 0.243939549499976 no 2566 0.230456277254036 3766 17169793
SGTC_932 2857-0803 154 µM -0.737574092656685 0.243865515546202 no 2567 0.230386651746724 3838 674898
SGTC_3277 9138724 49.47 µM -0.737757486141795 0.243806250626708 no 2568 0.23033091609026 3685 15943418
SGTC_733 4069-0007 56.1 µM -0.739632454635133 0.243200787370807 no 2569 0.229761521653002 3763 5717425 YNL287W SEC21
SGTC_2639 lactacystin 53 µM -0.740549509592433 0.242904949038039 no 2570 0.229483315743236 3759 3870 A proteasome inhibitor.
SGTC_1764 st044502 93.5 µM -0.740751314872064 0.242839873594112 no 2571 0.229422119658062 3764 8407
SGTC_1786 berberine 21.6 µM -0.740765810343935 0.242835199653106 no 2572 0.229417724356434 3709 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2818 7996756 12.99 µM -0.741644737343496 0.242551888142302 no 2573 0.229151305247022 3749 2241621
SGTC_2359 9039622 200 µM -0.74838680361836 0.240384629438581 no 2574 0.227113439980768 3706 6463596
SGTC_1250 0485-0349 40.2 µM -0.750518997093107 0.239701431039246 no 2575 0.226471093345686 3766 6842794 YDL195W SEC31
SGTC_1626 st003712 1.76 µM -0.750557496162295 0.23968910489672 no 2576 0.226459504515711 3715 24207035
SGTC_3346 9158254 43.5805 µM -0.750660637386061 0.239656084155726 no 2577 0.226428459023027 3760 17639500
SGTC_3219 9131112 49.47 µM -0.751917906563866 0.239253768136161 no 2578 0.226050214458798 3726 17612988 YMR079W SEC14
SGTC_2826 7992541 19.48 µM -0.751986921261072 0.239231694677083 no 2579 0.226029462000015 3810 2985066
SGTC_3330 9141424 71.43 µM -0.753384010941315 0.238785092938832 no 2580 0.225609594041158 3824 27261020
SGTC_2063 5246145 200 µM -0.754524235297979 0.238420940522889 no 2581 0.225267249260558 3794 711240
SGTC_3012 9080433 71.4286 µM -0.754974904561516 0.238277094580375 no 2582 0.225132019976705 3761 17688859
SGTC_2448 5185112 27.17 µM -0.755093855069061 0.23823913553838 no 2583 0.225096334973836 3760 5718189
SGTC_2275 7947463 200 µM -0.755195087403185 0.238206833263286 no 2584 0.225065967925222 3713 1225414
SGTC_1272 0839-0021 27 µM -0.755211993693766 0.238201438860584 no 2585 0.225060896707101 3797 5027250
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.755574354659876 0.238085834026826 no 2586 0.224952218324785 3763 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3113 9123498 49.47 µM -0.756147627004008 0.237903004482008 no 2587 0.224780344704465 3793 8897275
SGTC_1914 st062367 72.6 µM -0.756434200529844 0.237811638556752 no 2588 0.224694454599478 3785 978205
SGTC_2441 5730946 39.09 µM -0.756506280305039 0.23778866097284 no 2589 0.224672854209937 3823 1774275
SGTC_2411 st077133 39.94 µM -0.757698420827836 0.237408807199909 no 2590 0.224315772303294 3883 1403142 YNL221C POP1
SGTC_2894 9048625 32.47 µM -0.758200513661701 0.237248924260543 no 2591 0.224165476887565 3792 4092861
SGTC_1088 bifonazole 369 nM -0.758575742746478 0.237129477552693 no 2592 0.224053193949327 3699 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1325 1431-0015 227 µM -0.76014197314839 0.236631256264516 no 2593 0.223584862870435 3726 1103340
SGTC_413 propylparaben 100 µM -0.761039778536805 0.236345922301482 no 2594 0.223316654135095 3733 7175 A pharmaceutical preservative.
SGTC_1818 st052136 56.3 µM -0.762498102241647 0.235882852501291 no 2595 0.222881387682599 3645 674169
SGTC_541 4513-1321 94 µM -0.762653377674189 0.235833576489457 no 2596 0.222835071050977 3786 747515
SGTC_732 3970-1727 52.7 µM -0.763108430013497 0.235689200215146 no 2597 0.222699366477348 3791 1275699
SGTC_1760 st045453 10.4495 µM -0.763327393296835 0.235619746233947 no 2598 0.222634084582586 3822 3323419 YIL048W NEO1
SGTC_1579 chlormadinone acetate 49.4 µM -0.764369365611298 0.235289392932746 no 2599 0.222323579606619 3793 45114258 A steroidal progestin.
SGTC_2310 7668677 200 µM -0.765420621149956 0.234956355721778 no 2600 0.222010558772141 3767 2197143
SGTC_2166 5933061 31.504 µM -0.765591884812165 0.234902124166635 no 2601 0.221959587315217 3910 2877375
SGTC_3200 9114385 49.47 µM -0.766611897483432 0.234579275027427 no 2602 0.221656149795311 3784 17018030 YLR208W SEC13
SGTC_1558 st069300 45.6 µM -0.766881744323845 0.234493905570354 no 2603 0.221575914327256 3716 24208000
SGTC_922 1866-0035 480 µM -0.766931515947958 0.234478161565919 no 2604 0.221561117191948 3752 3156169
SGTC_2608 thymoquinone 42.66 µM -0.767712565490583 0.23423117275231 no 2605 0.221328984656521 3742 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2536 dehydroabietamide 32.04 µM -0.768876338038007 0.233863423991064 no 2606 0.220983362735233 3799 3983547
SGTC_1021 4476-0760 85.3 µM -0.771018700414239 0.233187281033497 no 2607 0.220347923663801 3811 746768
SGTC_2056 5235370 200 µM -0.772041350570028 0.232864909270738 no 2608 0.220044968479552 3783 5511916
SGTC_2734 clemastine 41.6 µM -0.772141490198407 0.232833355398757 no 2609 0.220015315447496 3789 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2398 5228213 48.84 µM -0.772655341237265 0.232671478952944 no 2610 0.219863191562487 3783 80771 YMR134W ERG29
SGTC_1520 flindersine 88 µM -0.77305184169591 0.232546613762777 no 2611 0.219745850198807 3899 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1360 1598-0022 39.8 µM -0.773428705641245 0.232427967011309 no 2612 0.21963435344924 3862 761525
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.774653805532595 0.232042505831569 no 2613 0.219272127142707 3835 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2970 9090938 41.86 µM -0.774953082565995 0.231948396462252 no 2614 0.219183691865419 3797 17217104
SGTC_2749 bexarotene 57.39 µM -0.777141001335603 0.231261038986764 no 2615 0.218537793011111 3824 82146 An retinoic acid receptor inhibitor.
SGTC_3049 9092223 49.47 µM -0.777253245358176 0.231225807026321 no 2616 0.218504686861416 3776 8623917
SGTC_2462 5162487 171.77 µM -0.777338955732078 0.231198905654688 no 2617 0.218479408702979 3714 2259986
SGTC_2141 5621638 7.665 µM -0.777758017349054 0.231067402585467 no 2618 0.21835584107443 3839 2856238
SGTC_1024 4507-0395 26 µM -0.777947297306594 0.231008019530962 no 2619 0.218300041777814 3865 4201836
SGTC_1618 st003135 44.5 µM -0.778549005719432 0.230819301341151 no 2620 0.218122714095753 3716 1270615
SGTC_2084 5306078 60.6385 µM -0.778726865408118 0.230763534403425 no 2621 0.218070313501993 3741 679340
SGTC_3187 9109394 49.47 µM -0.779285841038345 0.230588319637126 no 2622 0.217905676693127 3769 17098090
SGTC_700 3453-2283 142 µM -0.779428258063227 0.230543689924875 no 2623 0.217863741629836 3849 565664
SGTC_1089 terbinafine 2.25 µM -0.779670901486956 0.230467663041938 no 2624 0.217792305363964 3802 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.78034738556129 0.230255775926163 no 2625 0.217593214119724 3639 6708630 An antioxidant.
SGTC_67 0335-0847 266 µM -0.78072611502953 0.230137198556894 no 2626 0.217481798804093 3961 4552207 YOR254C SEC63
SGTC_329 k048-0121 21.3 µM -0.78136344570545 0.229937732218544 no 2627 0.217294382077658 3798 6832902
SGTC_885 0865-0106 16.8 µM -0.78252746840404 0.229573676176479 no 2628 0.216952324450078 3736 2793380
SGTC_2744 captopril 92.04 µM -0.782972246913524 0.229434653980148 no 2629 0.216821704858127 3748 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1258 0671-0043 57.1 µM -0.783409273709369 0.229298100666636 no 2630 0.216693406035978 3830 4298767
SGTC_1510 1123-0200 71.5 µM -0.783529333160992 0.229260594891854 no 2631 0.21665816763439 3840 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1027 k015-0025 8.67 µM -0.784043772955093 0.229099926271361 no 2632 0.21650721300677 3799 3598955
SGTC_339 3091-4833 71.4 µM -0.784289906323752 0.229023076823317 no 2633 0.216435010397287 3739 3240077
SGTC_764 1951-2361 146 µM -0.784540798570745 0.228944756412546 no 2634 0.216361426126165 3789 5438930
SGTC_455 paf C-16 10 µM -0.785933899898508 0.228510148946093 no 2635 0.215953106485662 3778 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2773 thioridazine 9.09 µM -0.786151851464949 0.228442196289854 no 2636 0.215889265037913 3831 5452 An antipsychotic.
SGTC_780 0109-0199 192 µM -0.78643934614865 0.228352578938916 no 2637 0.215805070045267 3840 610414
SGTC_3070 9117005 49.47 µM -0.787089581010633 0.228149961735172 no 2638 0.215614714060486 3840 8779016
SGTC_1060 3448-7350 82 µM -0.789018455594072 0.227549507572557 no 2639 0.21505060994601 3746 570178
SGTC_2676 harmalol 100 µM -0.789454398839903 0.227413922851874 no 2640 0.214923236096456 3790 5459187 A monoamine oxidase inhibitor
SGTC_122 0236-0016 402.397 µM -0.791116241765079 0.226897483032577 no 2641 0.214438081089776 3839 6808838
SGTC_1629 st005085 44.9 µM -0.791257782884259 0.226853527836051 no 2642 0.214396789316245 3810 24207091
SGTC_2629 bisabolol 100 µM -0.792699887562829 0.226405960165258 no 2643 0.213976347919264 3833 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1744 st037937 38.9 µM -0.792994959364846 0.226314443981893 no 2644 0.213890379787183 3871 1016152
SGTC_2958 9077254 16.72 µM -0.793406829161529 0.226186737979827 no 2645 0.213770416601855 3841 16457351
SGTC_2198 6589944 200 µM -0.793425135227961 0.226181062872687 no 2646 0.21376508559827 3819 5290268
SGTC_749 1000-0129 128 µM -0.794594451943686 0.225818726971457 no 2647 0.213424723337541 3859 708470
SGTC_132 0417-1715 25.805 µM -0.79465406791407 0.225800262583937 no 2648 0.213407378912922 3806 6769098
SGTC_3291 9121177 71.43 µM -0.794758385419341 0.225767955194674 no 2649 0.213377031184854 3835 17015612
SGTC_2307 7538926 6.34 µM -0.79496603839365 0.225703652338515 no 2650 0.213316628908524 3850 96582
SGTC_591 4299-0174 154 µM -0.795040222614894 0.225680682594615 no 2651 0.213295052555366 3824 5509088
SGTC_2977 9011197 71.43 µM -0.795260732431706 0.225612413700782 no 2652 0.213230925167551 3892 2704722
SGTC_2401 5128683 200 µM -0.795262564989869 0.225611846397598 no 2653 0.21323039228071 3805 708373
SGTC_3019 9081971 49.47 µM -0.798885189032324 0.224491973419944 no 2654 0.212178493891411 3837 16451803
SGTC_2189 6047310 154.431 µM -0.799196818479113 0.224395786007932 no 2655 0.212088148228389 3777 711535
SGTC_993 3909-8757 62.7 µM -0.799852404542916 0.224193509479847 no 2656 0.211898158264789 3803 4288324 YLR208W SEC13
SGTC_2936 9038235 15.59 µM -0.800583924796864 0.22396792626087 no 2657 0.211686280015994 3790 4749415
SGTC_2681 menadione 3.18 µM -0.800711131432768 0.223928711966958 no 2658 0.21164944842039 3864 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2185 6113692 200 µM -0.801811633522745 0.223589620478289 no 2659 0.211330964067186 3814 874150
SGTC_622 1348-1566 26.3 µM -0.802825588083669 0.223277455032644 no 2660 0.211037775127557 3883 7340407
SGTC_2412 st077135 33.4 µM -0.802845366305312 0.223271368393561 no 2661 0.211032058548952 3929 13258915
SGTC_22 0964-0034 14.468 µM -0.803340807443097 0.223118929920012 no 2662 0.210888888831306 3863 138402
SGTC_2376 9072922 81.32 µM -0.804095652489427 0.222886791413803 no 2663 0.210670867599132 3874 17087968
SGTC_1182 1222-0449 220 µM -0.806658134857249 0.22209977497497 no 2664 0.209931735142312 3842 658318
SGTC_2710 st078562 53.7235 µM -0.806908216284976 0.222023052396363 no 2665 0.209859682391896 3811 17250908
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.807548189015154 0.221826783833873 no 2666 0.209675361476908 3834 688751
SGTC_972 1319-0219 195 µM -0.809248883500127 0.221305692151211 no 2667 0.209186001045984 3834 23903702
SGTC_1569 carminic acid 40.6 µM -0.809995745811648 0.221077075437007 no 2668 0.208971310395122 3904 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_111 0083-0039 52.457 µM -0.811768269063832 0.220535042256221 no 2669 0.208462306339884 3742 759313
SGTC_1877 wortmannin 25 µM -0.812105461300029 0.220432015989198 no 2670 0.208365559861686 3847 312145 A covalent inhibitor of PI 3-kinase.
SGTC_3195 9113082 49.47 µM -0.812787660701928 0.220223660053083 no 2671 0.208169905675207 3762 17018038
SGTC_1012 4112-3522 18 µM -0.812951975436888 0.220173492266755 no 2672 0.208122796560517 3821 3112398
SGTC_3284 9108171 64.8615 µM -0.813015578691808 0.220154074985866 no 2673 0.208104563165516 3830 8687505
SGTC_3086 9117350 49.47 µM -0.816102857773071 0.219212748682656 no 2674 0.207220654799505 3761 2679265
SGTC_1824 st053723 68.6 µM -0.818558266146888 0.218465737472108 no 2675 0.206519243021465 3879 675225
SGTC_941 3237-0776 460 µM -0.820375735933788 0.217913752322684 no 2676 0.206000971683012 3894 760008
SGTC_627 1391-0720 175 µM -0.82048331355867 0.217881105069737 no 2677 0.205970318949504 3862 997839
SGTC_2786 7743617 45.45 µM -0.820555505769579 0.2178591980308 no 2678 0.205949750309749 3816 583674
SGTC_228 caffeine 993.056 µM -0.822154205390413 0.217374391366275 no 2679 0.205494569204373 3842 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_3025 9087895 49.47 µM -0.822721617286475 0.217202473248662 no 2680 0.20533315965959 3886 17173641
SGTC_827 3253-0474 693 µM -0.823382320953781 0.217002387995768 no 2681 0.205145306682778 3849 5402065
SGTC_1240 0356-0016 42.1 µM -0.823784297375085 0.216880706959683 no 2682 0.205031065692781 3866 4305613
SGTC_2449 5812982 45.77 µM -0.824615507718684 0.21662921900162 no 2683 0.2047949571558 3840 776185
SGTC_792 4534-1957 155 µM -0.82536738733355 0.216401878431174 no 2684 0.204581522176528 3835 1717904
SGTC_3231 9132313 49.47 µM -0.825528254806205 0.216353255998804 no 2685 0.204535874153972 3853 4905967
SGTC_1046 2001-0062 216 µM -0.826550415921414 0.216044454063843 no 2686 0.204245965650916 3771 739778
SGTC_418 lividomycin a 100 µM -0.827394608566709 0.215789610244579 no 2687 0.20400671771316 3837 72394 An antibiotic.
SGTC_2007 4011539 71.82 µM -0.828841164579367 0.215353331046917 no 2688 0.203597145730809 3865 45595301
SGTC_3131 9127911 49.47 µM -0.829663339441265 0.215105592574555 no 2689 0.203364577206673 3902 45595681
SGTC_2260 7964312 200 µM -0.831119239497202 0.214667305595328 no 2690 0.202953135982803 3922 231951
SGTC_2262 9014885 67.46 µM -0.834283903786615 0.213716401113141 no 2691 0.202060510014725 3817 6457424
SGTC_1699 st031318 29.054 µM -0.834505732676114 0.213649839083961 no 2692 0.201998029144938 3936 5340658
SGTC_454 lyso-paf C-16 6.67 µM -0.835026924493633 0.213493497674471 no 2693 0.201851274487195 3812 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_188 3229-0966 278.469 µM -0.83542029215944 0.213375543716951 no 2694 0.201740554216378 3923 5722370
SGTC_1717 st033143 58.0435 µM -0.836795029949383 0.212963617782826 no 2695 0.201353895773668 3876 674616
SGTC_2291 7917025 104.35 µM -0.837338298374769 0.212800961036566 no 2696 0.201201218755383 3836 2964612
SGTC_1655 st012546 55.1 µM -0.837504669663079 0.212751163314172 no 2697 0.201154476617742 3855 720985 YLR208W SEC13
SGTC_2566 crystal violet carbinol 226 nM -0.83797612713782 0.212610085130331 no 2698 0.201022055665168 3935 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_131 0141-0277 33.849 µM -0.838152682308042 0.212557267106648 no 2699 0.200972479067565 3844 1547771
SGTC_2877 9040724 71.43 µM -0.838423470255808 0.212476273416321 no 2700 0.200896456210154 3825 6463895
SGTC_2386 9075165 157.42 µM -0.839114487724881 0.212269669228411 no 2701 0.200702533463788 3848 16452277
SGTC_1619 st003326 88.7 µM -0.840738475914137 0.21178458283457 no 2702 0.200247230325518 3858 2849032
SGTC_1422 4031-0024 15.5 µM -0.841544357733257 0.211544106387027 no 2703 0.200021523003948 3842 782427
SGTC_804 1595-0054 20.9 µM -0.842456530887709 0.211272105413524 no 2704 0.199766230766803 3842 761523 Stimulates phospholipase C.
SGTC_2025 5147754 141 µM -0.842580239681933 0.211235232464617 no 2705 0.199731623169892 3874 315777 YLR208W SEC13
SGTC_2561 acetosyringone 100 µM -0.842890211581592 0.21114285803597 no 2706 0.199644924219069 3905 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2563 tomatine 8.54 µM -0.843157377666634 0.211063259125678 no 2707 0.199570216201759 3796 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_3236 9132701 49.47 µM -0.843453991080717 0.210974907346287 no 2708 0.199487293498989 3889 24282524
SGTC_1152 3909-8331 15.9 µM -0.844131793882861 0.210773092677177 no 2709 0.199297881480956 3862 16001939
SGTC_3098 9119039 49.47 µM -0.844266342241923 0.210733044598603 no 2710 0.199260294824172 3868 17161528
SGTC_3153 9100258 49.47 µM -0.844796681394129 0.210575233575253 no 2711 0.199112183906334 3822 25236848
SGTC_165 k038-0023 64.381 µM -0.846216960021213 0.210152948314087 no 2712 0.198715861158732 3913 46368543
SGTC_2727 riluzole 51.77 µM -0.846813105083101 0.209975847417252 no 2713 0.198549651226342 3900 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2380 9035439 200 µM -0.847470338408761 0.209780700292215 no 2714 0.198366506625972 4019 6462575
SGTC_3082 9117008 49.47 µM -0.847482252076715 0.209777163844645 no 2715 0.198363187704939 3965 41448529
SGTC_2074 5212007 75.395 µM -0.848981922948931 0.209332282204995 no 2716 0.197945675595774 3755 758611
SGTC_10 0279-0212 42.575 µM -0.848986979473629 0.209330783112392 no 2717 0.197944268745164 3875 39851 YBR002C RER2
SGTC_1875 nocodazole 6 µM -0.852695083209963 0.208233154889139 no 2718 0.196914209106694 3877 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_312 4092-0653 6.84 µM -0.85270979499622 0.208228806857515 no 2719 0.19691012885082 3880 1148278
SGTC_1301 naphtanilide LB 4.81 µM -0.852717706481032 0.208226468660121 no 2720 0.196907934652886 3975 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1010 4112-3296 15.2 µM -0.853036616095639 0.208132229513162 no 2721 0.196819499507545 3988 704384
SGTC_1833 st055984 71 µM -0.854461301668444 0.207711536373577 no 2722 0.196424721255844 3930 676288
SGTC_2336 9001819 198.65 µM -0.854589753286398 0.207673630802487 no 2723 0.196389151104261 3918 2989602
SGTC_1578 josamycin 24.2 µM -0.854814712815619 0.20760725597031 no 2724 0.196326865892355 3922 5282165 A P450 substrate.
SGTC_487 nimodipine 119 µM -0.855729930821408 0.207337348036538 no 2725 0.196073590252875 3807 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2203 7227154 166.4 µM -0.856172623301262 0.207206867601245 no 2726 0.195951151549658 3894 896304
SGTC_1523 st012844 44.7 µM -0.856242462337325 0.207186287481981 no 2727 0.19593183989276 4048 4274103
SGTC_2586 curcumin 80 µM -0.857375400756948 0.206852602879696 no 2728 0.195618724876252 3909 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_314 1671-0008 2.74 µM -0.858040459616934 0.206656871211863 no 2729 0.195435061324053 3823 3913060
SGTC_1145 3546-0597 10.2 µM -0.859258948695703 0.20629854568665 no 2730 0.195098833592286 3890 875334
SGTC_920 mycophenolic acid 780.421 nM -0.860353888730606 0.20597686701674 no 2731 0.194796997903318 3945 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1403 3909-7815 62.9 µM -0.860488228101844 0.205937420414359 no 2732 0.194759984929787 3853 6615483
SGTC_639 0833-0042 114 µM -0.861161049182129 0.20573992472447 no 2733 0.194574674693585 3904 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1791 st048313 56.1 µM -0.864855827929986 0.204657387449769 no 2734 0.19355896231927 3899 1204976
SGTC_367 0335-0881 7.1 µM -0.865652835633314 0.204424316389352 no 2735 0.193340285861654 3926 23828853
SGTC_3230 9131665 49.47 µM -0.867060264730899 0.204013124241789 no 2736 0.192954495316052 3842 15943720
SGTC_742 0kpi-0133 140 µM -0.868342574621289 0.203638916071599 no 2737 0.192603410826507 3991 2728852
SGTC_2691 st077356 60.2 µM -0.868369628650325 0.203631025481207 no 2738 0.192596007893684 4003 2839272
SGTC_950 1165-0508 94.1 µM -0.869226682921024 0.203381151029216 no 2739 0.192361577765065 3954 6148369
SGTC_1101 ebselen 5.29 µM -0.869498601922087 0.203301911201354 no 2740 0.192287236216481 3987 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_342 k048-0088 23.3 µM -0.870666153337303 0.202961884864823 no 2741 0.191968232163374 3930 6820570
SGTC_1293 1000-1278 195 µM -0.871575248249309 0.202697364226652 no 2742 0.191720069278805 3983 678847
SGTC_845 0330-0138 4.51 µM -0.872350776362618 0.202471870629933 no 2743 0.191508522542992 3873 9039800
SGTC_865 0488-0499 301 µM -0.872613646769575 0.202395472124755 no 2744 0.191436849835759 3918 9634651
SGTC_1174 0739-0097 51.1 µM -0.873003464743247 0.202282210358593 no 2745 0.191330594611746 3951 728447
SGTC_1921 5740136 50 µM -0.875004287079179 0.201701467575279 no 2746 0.190785786533379 3839 1774243
SGTC_2102 5377816 72.7585 µM -0.876757260459982 0.201193485087795 no 2747 0.190309248960431 3983 1379702
SGTC_1252 0493-0875 34.8 µM -0.877017394978723 0.201118167857145 no 2748 0.190238594965679 3923 3960963
SGTC_2284 7945075 39.21 µM -0.877544218790533 0.200965687387972 no 2749 0.190095556036281 3973 1245402
SGTC_2309 7664088 163.95 µM -0.880637595215998 0.200071760640576 no 2750 0.18925700165677 3964 704922
SGTC_2597 laccaic acid a 100 µM -0.881671781485798 0.199773434522602 no 2751 0.188977162541936 3967 5491415 A textile dye.
SGTC_896 0964-0007 44.5 µM -0.882611157290439 0.19950268991663 no 2752 0.18872319910954 3883 6756758
SGTC_1202 1988-0068 29.6 µM -0.883349726728677 0.199289976399517 no 2753 0.188523672151564 3907 2850480
SGTC_1255 0566-0045 221 µM -0.883846052515655 0.199147107624714 no 2754 0.18838966121819 4001 2788469
SGTC_1307 1187-1599 12.2 µM -0.884482954290794 0.198963864068005 no 2755 0.188217780029775 3940 1538471
SGTC_1713 st033146 12.748 µM -0.885803928835908 0.198584129417859 no 2756 0.187861596179853 3913 674619
SGTC_1395 3486-0190 4.35 µM -0.886441269678875 0.19840107233231 no 2757 0.187689894350797 3922 6748079
SGTC_923 1900-2434 73.3 µM -0.886653574141566 0.198340116843264 no 2758 0.187632720325622 3909 5910570
SGTC_2121 5257820 149.641 µM -0.887386137339796 0.198129874813748 no 2759 0.187435522194628 4013 791256
SGTC_1603 st002045 67.8 µM -0.887428731547056 0.198117654626698 no 2760 0.187424060234315 3948 5887985
SGTC_1157 4092-0394 27.6 µM -0.887799992297415 0.19801115998194 no 2761 0.187324173540201 4051 3659885
SGTC_1899 st063254 59.6 µM -0.89183491885318 0.196855988611128 no 2762 0.186240711103207 3897 3093813
SGTC_2308 7584454 197.62 µM -0.893027886800624 0.196515233312171 no 2763 0.185921119447533 3997 893577
SGTC_2220 6782180 200 µM -0.894331075568952 0.196143403666692 no 2764 0.185572388959345 3871 833803
SGTC_1827 berberine 7.24 µM -0.895142169156208 0.195912195624664 no 2765 0.185355547150881 3905 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_16 erodoxin 22.806 µM -0.896871433200941 0.195419808935284 no 2766 0.18489376255593 3966 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3146 9095609 49.47 µM -0.897048125792032 0.195369540252688 no 2767 0.184846618662234 4018 17173999
SGTC_1277 0873-0036 22 µM -0.897162536716034 0.195336994767981 no 2768 0.184816096317093 4028 5965735
SGTC_3105 9121040 49.47 µM -0.897220419876021 0.195320530501548 no 2769 0.184800655542857 3783 41448907
SGTC_2279 7948423 32.93 µM -0.897582037842415 0.195217691097509 no 2770 0.184704209347088 3889 1247112
SGTC_1498 4478-3555 97.6 µM -0.897797701854585 0.195156374749088 no 2771 0.1846467050537 3899 3437919
SGTC_2860 9025725 38.96 µM -0.897948284825528 0.195113568807498 no 2772 0.184606560461365 3965 40546248
SGTC_2838 9002687 71.43 µM -0.898406041102613 0.194983478327784 no 2773 0.184484558483887 3947 6457060
SGTC_3216 9129716 49.47 µM -0.898667405114087 0.194909224533476 no 2774 0.18441492180246 3939 8056934
SGTC_702 1488-0190 94 µM -0.9003212405304 0.194439766903363 no 2775 0.183974660336687 4002 949357
SGTC_185 k048-0037 25.491 µM -0.902613022329319 0.193790360780286 no 2776 0.183365656356438 4014 6827589
SGTC_848 0368-0089 85.6 µM -0.905580587493315 0.192951429858216 no 2777 0.182578943778896 3985 762535
SGTC_606 k015-0008 38.6 µM -0.906795844393515 0.192608517739673 no 2778 0.182257383927813 4047 1970475
SGTC_1900 st060200 72.8 µM -0.906801678609168 0.192606872383146 no 2779 0.182255841034689 3956 688945
SGTC_2227 7312221 64.1025 µM -0.906841314775026 0.192595694480031 no 2780 0.182245359230348 4037 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1132 3456-3614 2.5 µM -0.908435518975747 0.192146437348263 no 2781 0.181824083459351 4072 3125502
SGTC_1860 st056228 74.6 µM -0.908749695999183 0.192057975902207 no 2782 0.181741132647913 3968 688679
SGTC_2131 toluylene red 5.2905 µM -0.908770585561333 0.192052095003574 no 2783 0.181735618106009 3972 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_3107 9121808 49.47 µM -0.911525876507925 0.191277382436922 no 2784 0.181009178874446 3868 662681
SGTC_1209 2323-2347 50.3 µM -0.911951436861682 0.191157897497917 no 2785 0.180897141271404 3979 5412760
SGTC_2886 9058944 51.95 µM -0.913471323126035 0.190731531464989 no 2786 0.180497354551727 3840 4949929
SGTC_2620 irigenin 100 µM -0.915430897195233 0.190182684090646 no 2787 0.179982732144896 4048 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1087 pterostilbene 9.05 µM -0.917795863100501 0.189521586309557 no 2788 0.179362874237804 4054 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1273 0849-0096 14.1 µM -0.918583281210782 0.189301787196642 no 2789 0.179156790043423 4018 5286025
SGTC_382 3229-0966 23.2 µM -0.918664382095137 0.189279157693055 no 2790 0.179135572667599 4015 5722370
SGTC_2922 7999257 32.47 µM -0.918758881836214 0.189252791619994 no 2791 0.179110851916165 3950 2988377
SGTC_374 0880-0231 82.3 µM -0.919950858738668 0.188920416092464 no 2792 0.17879921984303 3917 6833587
SGTC_2329 6138490 200 µM -0.920658565638995 0.188723246578854 no 2793 0.178614357564521 4136 720019
SGTC_1575 cyproterone acetate 48 µM -0.920930933463638 0.188647397802993 no 2794 0.178543243620915 4020 9880 An androgen receptor antagonist and liver toxin.
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.921274599210948 0.188551720857883 no 2795 0.178453539578573 4063 6710655
SGTC_3177 9107506 49.47 µM -0.922440458321428 0.188227367301119 no 2796 0.178149437224814 3933 8897194
SGTC_3185 9108267 49.47 µM -0.923384867482794 0.187964875876631 no 2797 0.177903337441848 3998 4910486
SGTC_1948 st076329 66.6 µM -0.923701088159155 0.187877035246187 no 2798 0.17782098270606 3866 24208413
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.92588514393969 0.187271034720311 no 2799 0.177252836289377 4058 688798
SGTC_771 0250-0039 27.3 µM -0.929090062321506 0.186383970696828 no 2800 0.176421207077124 3962 3005115
SGTC_2316 5844804 197.44 µM -0.929505558835508 0.186269159606227 no 2801 0.176313572872956 4044 776813
SGTC_1688 st021091 57.6 µM -0.929714778611009 0.186211364039472 no 2802 0.176259390307262 4002 3656366
SGTC_3103 9120822 49.47 µM -0.932607541076444 0.185413397164309 no 2803 0.175511319180589 4033 17141819
SGTC_648 0375-0473 33.3 µM -0.934866555646556 0.184791727709684 no 2804 0.174928537309035 3983 1713139
SGTC_2342 7990637 118.86 µM -0.935624505843681 0.184583434247759 no 2805 0.1747332763251 4086 2033102 YER133W GLC7
SGTC_1369 1866-0067 208 µM -0.937565576678357 0.184050671659378 no 2806 0.174233854345809 4012 3531355
SGTC_912 3474-0017 2.18 µM -0.938557427063317 0.183778810029758 no 2807 0.17397900972086 4072 3360550
SGTC_1627 st003713 25.6 µM -0.939911614566175 0.183408037613686 no 2808 0.173631449606911 4064 16195070 YER133W GLC7
SGTC_2466 5983409 37.09 µM -0.940097158213231 0.18335727267753 no 2809 0.173583863183796 4029 2879657
SGTC_2666 tannic acid 100 µM -0.940742025154131 0.183180904552873 no 2810 0.173418538559189 4021 16134267 A thiamine antagonist.
SGTC_2396 5342950 42.78 µM -0.941155536957328 0.183067866686342 no 2811 0.173312579241998 4016 1886677
SGTC_2825 7998094 58.44 µM -0.942485265936786 0.182704666129484 no 2812 0.172972125572656 4031 2987815
SGTC_2539 epi(13)torulosol 80 µM -0.946075693163591 0.181726230617466 no 2813 0.172054990210347 4072 6708597
SGTC_1112 tnp00069 1.16933 µM -0.947505798263383 0.18133742404999 no 2814 0.17169055152672 4042 145826
SGTC_2350 9023895 38.85 µM -0.949068679206851 0.180913115492348 no 2815 0.171292841458233 4055 2997209
SGTC_2251 lansoprazole 556 µM -0.949759544118251 0.180725750169697 no 2816 0.171117223280352 3954 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1942 st076330 65.2 µM -0.949924135300187 0.180681130335042 no 2817 0.171075401117091 4072 24208414
SGTC_1990 st072050 59.8 µM -0.951296876608116 0.180309256222837 no 2818 0.170726846037093 4014 17233948
SGTC_3267 9137951 49.47 µM -0.954178439555891 0.179530207576039 no 2819 0.16999666315336 4062 16643986
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.957200881987628 0.178715348267874 no 2820 0.169232935992803 4028 16486 A toxic proline analog.
SGTC_2899 9053889 58.44 µM -0.95723136870505 0.178707140840337 no 2821 0.169225243682208 4003 6470052
SGTC_2014 4013930 200 µM -0.958807971539292 0.178283022014704 no 2822 0.168827746311132 3966 64556
SGTC_2533 agelasine 13.65 µM -0.960433610305165 0.17784637691428 no 2823 0.168418514598116 4106 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_411 enrofloxacin 100 µM -0.961240264096047 0.177629961048797 no 2824 0.168215687836547 4137 71188 A bacterial gyrase inhibitor.
SGTC_2709 st078560 56 µM -0.961984196826538 0.177430519885434 no 2825 0.168028771141062 4039 17250903
SGTC_2954 9074818 52.69 µM -0.963370187459025 0.17705932641018 no 2826 0.167680890931939 4069 16648742
SGTC_928 2764-0428 58.7 µM -0.963885820736915 0.176921355754443 no 2827 0.167551586726242 4085 662578
SGTC_2495 cafestol 54.53 µM -0.964512136614896 0.17675386059616 no 2828 0.167394613309381 4067 16667697 An anti-infammatory.
SGTC_1453 4237-0541 195 µM -0.967544354022095 0.175944375249303 no 2829 0.16663598981139 4045 739892
SGTC_394 menadione 8.33 µM -0.967605835470635 0.175927986388466 no 2830 0.166620630895205 4034 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2761 levamisole 97.89 µM -0.96917704250529 0.17550948416486 no 2831 0.166228431690617 4009 26879 An alkaline phosphatase inhibitor.
SGTC_2290 7904846 200 µM -0.969536712473092 0.175413772323594 no 2832 0.166138736070175 4101 2962154
SGTC_716 1683-5115 658 µM -0.972500443882592 0.17462635330115 no 2833 0.165400822081691 3996 723597
SGTC_985 1493-0307 8.71 µM -0.973474939758531 0.174367935423959 no 2834 0.16515865468051 4071 3278274
SGTC_3261 9137475 49.47 µM -0.974060640721497 0.174212735557839 no 2835 0.165013215358522 3983 17027690
SGTC_2206 7254556 146.969 µM -0.980580343123206 0.172491066583084 no 2836 0.163399865868655 4058 4398905
SGTC_2081 5214970 32.255 µM -0.980605673949882 0.172484398660704 no 2837 0.163393617613545 4011 2063512
SGTC_1775 st081588 35.1725 µM -0.984886090143874 0.171360011030689 no 2838 0.162340013313432 4077 1426443 YGL099W LSG1
SGTC_435 c-PAF 6.7 µM -0.985514521986555 0.171195328708427 no 2839 0.162185700897471 4068 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1094 duloxetine 25.4 µM -0.985588310490354 0.171175998865801 no 2840 0.162167588283244 4068 60834 A selective serotonin reuptake inhibitor.
SGTC_2147 5545932 89.7195 µM -0.986567726895172 0.170919560425867 no 2841 0.161927299028627 4086 797404
SGTC_1475 4092-1048 11.7 µM -0.986633007114235 0.170902476991671 no 2842 0.161911291480145 4097 2881759
SGTC_1705 st027868 56.3335 µM -0.98719398019045 0.17075571880185 no 2843 0.161773776170145 4025 292948
SGTC_2876 9059903 25.97 µM -0.989830322086927 0.170067096545302 no 2844 0.161128530638435 4043 6916095
SGTC_799 1310-0557 151 µM -0.990656130808387 0.16985175884503 no 2845 0.16092675955245 4149 5354492
SGTC_2018 5133068 143 µM -0.991524789498065 0.169625436353034 no 2846 0.160714696933793 4048 785362
SGTC_2321 7390090 138.78 µM -0.991857416607479 0.169538824104986 no 2847 0.160633542176493 4116 649046
SGTC_898 1000-0849 28.3 µM -0.992231899451278 0.169441347069882 no 2848 0.160542207442262 4075 6751807
SGTC_1181 1222-0449 220 µM -0.994635805324159 0.168816472505359 no 2849 0.159956713290451 4152 658318
SGTC_15 0266-0086 27.098 µM -0.99471309747988 0.168796405677686 no 2850 0.159937911251727 4142 1712902 YIL048W NEO1
SGTC_556 4058-0063 51.5 µM -0.995811517125184 0.168511396260805 no 2851 0.159670866654349 4119 6615692
SGTC_2481 5478948 45.16 µM -0.999206220460242 0.167632521977744 no 2852 0.158847401572971 4130 77792
SGTC_1487 3970-0795 2.82 µM -0.999554199837369 0.167542598718743 no 2853 0.158763148564162 4130 3765103
SGTC_107 0358-0022 2.6945 µM -1.00197014291407 0.166919138628079 no 2854 0.15817900662305 4126 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_252 miconazole 1.30953 nM -1.0020281543244 0.166904186580566 no 2855 0.158164997622199 3992 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1457 k015-0032 57.3 µM -1.00215732336079 0.166870897241083 no 2856 0.158133807905597 4089 4302660
SGTC_653 0203-0016 55.2 µM -1.00235295695312 0.166820486866407 no 2857 0.158086577056268 4137 295302
SGTC_3010 9080089 71.4286 µM -1.00319645172777 0.166603249754293 no 2858 0.157883042333077 4111 17027233
SGTC_2864 9034755 47.6 µM -1.00378941966433 0.166450643695911 no 2859 0.157740062619293 4043 4930451
SGTC_404 fumagillin 50 µM -1.00508053071961 0.166118676008556 no 2860 0.157429037067923 4096 12015870 A methionine aminopeptidase binder.
SGTC_719 2810-4230 27.3 µM -1.00936737306482 0.165019522483237 no 2861 0.156399239913784 4091 721079
SGTC_1939 st074455 53.6 µM -1.0101096161592 0.164829689444334 no 2862 0.156221387803569 4123 1644229
SGTC_479 n-linoleoylglycine 10 µM -1.01331012110531 0.164012762086048 no 2863 0.155456027337973 4135 6433346 An anti-infammatory.
SGTC_1998 st075797 76.8 µM -1.01468246352432 0.163663278364885 no 2864 0.155128608047867 4092 24208315
SGTC_2177 5811945 192 µM -1.01643168889088 0.163218518197789 no 2865 0.154711930896531 4159 5343475
SGTC_753 1322-0200 289 µM -1.02088649628919 0.16208938393266 no 2866 0.153654108817775 4189 5403907
SGTC_2545 solidagenone 89.61 µM -1.02256321527249 0.161665716513686 no 2867 0.153257204670786 3926 6708572 An anti ulcer agent
SGTC_1740 st038286 13.222 µM -1.02352779020487 0.161422318478066 no 2868 0.153029183623357 4177 716786
SGTC_1562 morin hydrate 59.1 µM -1.02983774222241 0.159835981621782 no 2869 0.151543090104468 4186 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_254 nsc-64875 3.808 µM -1.03008867523595 0.159773108022434 no 2870 0.151484190440445 4121 56993
SGTC_2993 9054257 71.4286 µM -1.03174666923752 0.15935808892373 no 2871 0.151095404244249 4061 6470217 YGL055W OLE1
SGTC_4 0960-0234 25.671 µM -1.03285202957575 0.15908179428078 no 2872 0.150836575362407 4129 6821112
SGTC_2163 5671233 125 µM -1.03352666632829 0.158913317142708 no 2873 0.150678748952851 4094 701023
SGTC_607 4491-0986 66.8 µM -1.03485225134938 0.158582619323023 no 2874 0.150368958311195 4154 698981 YDR232W HEM1
SGTC_3340 9146634 11.102 µM -1.03589995411449 0.158321565183551 no 2875 0.150124409521807 4145 4907387
SGTC_483 fpl-64176 144 µM -1.03788347829503 0.157828106810493 no 2876 0.149662153131617 4204 3423
SGTC_186 3455-3465 67.277 µM -1.03889895530947 0.157575869207607 no 2877 0.149425866157899 4096 755278
SGTC_1634 st006576 41 µM -1.04500288123217 0.156065279559025 no 2878 0.148010818940424 4138 3915356
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.04516856559611 0.156024409740615 no 2879 0.147972534485445 4162 551469
SGTC_699 0375-0592 111 µM -1.04569301412652 0.15589508908265 no 2880 0.147851394595638 4213 762578
SGTC_1268 0828-0275 2.46 µM -1.04656729198145 0.155679663208164 no 2881 0.147649596926359 4194 745337
SGTC_3353 9151644 39.2805 µM -1.0468615022093 0.155607212696833 no 2882 0.14758172988445 4172 4909158
SGTC_2288 7946289 167.31 µM -1.04839792036952 0.155229224609645 no 2883 0.147227655652196 4212 1246052
SGTC_1042 0350-0096 82 µM -1.04890479174875 0.155104657676334 no 2884 0.147110969961446 4129 3122515
SGTC_722 3534-0461 190 µM -1.05215579637658 0.154307271725119 no 2885 0.1463640381432 4202 658262
SGTC_951 1171-0579 82.7 µM -1.05257352103318 0.154205011730271 no 2886 0.146268249102633 4105 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2273 7815444 169.05 µM -1.05262254198557 0.154193014223157 no 2887 0.146257010798386 4098 2824616
SGTC_2880 9042983 58.44 µM -1.05302375593093 0.154094843351592 no 2888 0.146165052242998 4141 6464714
SGTC_1106 tegaserod maleate 11.7 µM -1.05638569420984 0.153273853983973 no 2889 0.145396019577462 4160 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2048 5246248 200 µM -1.05750694771542 0.15300068819879 no 2890 0.145140142733592 4174 677046
SGTC_1378 2093-0007 380 nM -1.06092746126976 0.152169359537582 no 2891 0.144361434088897 4223 3618014
SGTC_1724 st037281 8.293 µM -1.06195472705174 0.151920277489822 no 2892 0.144128119235117 4124 574124 YDL195W SEC31
SGTC_3203 9113543 49.47 µM -1.06262200794408 0.15175862649097 no 2893 0.143976701228722 4236 17018012
SGTC_1443 4112-3303 14 µM -1.06265745520108 0.151750042474387 no 2894 0.143968660612372 4195 704433
SGTC_2823 7987624 58.44 µM -1.06277743308352 0.151720990656353 no 2895 0.143941447887321 4159 2239440
SGTC_2986 9022445 71.43 µM -1.06601819369322 0.150937661130941 no 2896 0.143207708791814 4166 6459286
SGTC_2083 5306046 65.942 µM -1.06782247584317 0.15050271371885 no 2897 0.142800298780978 4174 539837
SGTC_1727 st034309 9.9045 µM -1.06844043095019 0.150353939142922 no 2898 0.14266094374663 4234 870305
SGTC_580 1123-0028 41 µM -1.06869614868047 0.150292402995342 no 2899 0.142603303756942 4198 1677248 YPR107C YTH1
SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.06898233498166 0.15022355476808 no 2900 0.142538814683442 4170 77254
SGTC_2808 7946468 45.46 µM -1.06968387288399 0.150054873775177 no 2901 0.142380813937425 4152 2970879
SGTC_1731 st035964 63 µM -1.07232190449449 0.149421703948566 no 2902 0.141787735755537 4097 6739575
SGTC_2456 5770359 74.46 µM -1.07398266372639 0.14902401122733 no 2903 0.141415225817342 4189 3118787
SGTC_1156 4092-0367 4.88 µM -1.07423433717612 0.148963806146993 no 2904 0.14135883313837 4184 1357585
SGTC_1809 st050081 57.6 µM -1.07526117202794 0.148718336125032 no 2905 0.141128907373318 4256 5036894
SGTC_3138 9097216 49.47 µM -1.07607872739749 0.14852308885066 no 2906 0.140946024267698 4131 25237486
SGTC_2875 9039966 71.43 µM -1.07635791063263 0.14845645403093 no 2907 0.140883609191295 4183 6463691
SGTC_688 0527-0193 473 µM -1.07781126941308 0.148109892637228 no 2908 0.140558994656752 4236 4007154
SGTC_112 phenothiazine 287.218 µM -1.07785373296856 0.148099775115687 no 2909 0.140549517861491 4120 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_83 0170-0301 39.027 µM -1.07880489840608 0.147873268180843 no 2910 0.140337355375288 4179 3089716
SGTC_2267 7931562 200 µM -1.08206703113841 0.147098198729896 no 2911 0.139611372028077 4110 934880
SGTC_1657 st012939 43.4 µM -1.0822960830364 0.147043879460849 no 2912 0.139560492959502 4198 24207257
SGTC_1050 3232-1156 69.3 µM -1.0839070979934 0.146662210011829 no 2913 0.139202996082921 4157 700529
SGTC_2483 5729050 27.16 µM -1.08444344544974 0.146535290272414 no 2914 0.139084114767088 4207 2865180
SGTC_2387 9077560 195.08 µM -1.08449339650068 0.146523473751265 no 2915 0.139073046644548 4173 5303272
SGTC_1102 cgs 12066b 26.1 µM -1.08597175454592 0.146174039971065 no 2916 0.138745744434619 4180 6438352 A 5-HT1B full agonist.
SGTC_2050 5263056 171 µM -1.0882641148997 0.145633311298667 no 2917 0.138239263798343 4175 763468 YGL055W OLE1
SGTC_2967 9089538 49.85 µM -1.08892626506055 0.14547737203893 no 2918 0.138093201375269 4195 728216
SGTC_1859 st055998 20 µM -1.09059560971015 0.145084732664814 no 2919 0.137725431118388 4144 676301
SGTC_1845 st056753 3.01 µM -1.09237203448119 0.144667691463895 no 2920 0.137334804918249 4158 5375839
SGTC_1204 4049-0315 18.3 µM -1.09279597187058 0.144568285541367 no 2921 0.137241695313581 4237 588402
SGTC_1832 st054113 55 µM -1.09824993285443 0.143293531067101 no 2922 0.136047683897618 4197 1251267
SGTC_3248 9135562 49.47 µM -1.09906014060121 0.143104810769993 no 2923 0.135870917208961 4176 17650701
SGTC_2871 9038510 12.99 µM -1.10056670632154 0.142754335590277 no 2924 0.135542641219608 4160 4945164
SGTC_1854 st056233 32.9 µM -1.10292260521275 0.142207442477428 no 2925 0.13503038829246 4132 5393174
SGTC_925 2064-1272 59.6 µM -1.10397866572865 0.141962751767345 no 2926 0.134801196174753 4176 6815817
SGTC_1606 st000094 49.2 µM -1.10511178958749 0.141700522553455 no 2927 0.134555576335183 4234 1242210
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.1055247698197 0.141605031684288 no 2928 0.134466133747006 4255 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2516 gossypol 71.55 µM -1.10556281268339 0.141596237461288 no 2929 0.134457896539058 4220 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_460 trequinsin 123 µM -1.10694317253157 0.141277395238294 no 2930 0.13415924927848 4266 5537 A vasodilator.
SGTC_1892 st058411 7.36 µM -1.10882225763666 0.140844137816064 no 2931 0.13375343332665 4213 3934738
SGTC_2544 sphondin 68.51 µM -1.11016463383727 0.140535181002007 no 2932 0.133464044779879 4200 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_790 1575-0012 79.1 µM -1.11063561363199 0.14042689097619 no 2933 0.13336261340645 4263 378741 YLR208W SEC13
SGTC_468 gf-109203x 121 µM -1.11063860836755 0.140426202592955 no 2934 0.133361968622509 4190 2396 A protein kinase C inhibitor.
SGTC_315 k915-0449 187 µM -1.11116730210784 0.140304710604875 no 2935 0.133248171401107 4213 20970215 YNL149C PGA2
SGTC_3058 9093861 49.47 µM -1.11602415778294 0.139191962177959 no 2936 0.132205897024447 4232 17217477
SGTC_1771 st048882 4.1505 µM -1.11923787962468 0.138458980682782 no 2937 0.131519334688425 4241 4580403
SGTC_2375 9072683 200 µM -1.12081213515158 0.138100888082919 no 2938 0.131183918792344 4291 16798029
SGTC_1996 st072960 66.8 µM -1.12171210150282 0.137896458593272 no 2939 0.130992434748806 4246 1719405
SGTC_417 st075190 100 µM -1.12433192458297 0.137302535175154 no 2940 0.130436119911347 4222 222757
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.12470111929848 0.137218978045683 no 2941 0.13035785362395 4246 6728940
SGTC_1607 st000305 50.6 µM -1.12651630709991 0.136808665153044 no 2942 0.129973521060266 4233 5457690
SGTC_2357 9067248 200 µM -1.12789411464347 0.136497780031291 no 2943 0.129682319849921 4200 9150235
SGTC_1203 3992-3522 103 µM -1.12790312349415 0.136495748887567 no 2944 0.129680417307094 4347 5322312
SGTC_2795 7780010 54.55 µM -1.12943179073361 0.136151393507939 no 2945 0.129357864157196 4199 953673
SGTC_173 1273-0061 2.693 µM -1.13144553560092 0.135698675277563 no 2946 0.128933807482165 4195 2847414 YPL266W DIM1
SGTC_1773 st048542 73.5835 µM -1.13230200559667 0.135506441636003 no 2947 0.128753743607891 4180 3237138
SGTC_1238 0333-0287 48.8 µM -1.13662343934303 0.134539347776063 no 2948 0.127847868571421 4200 7226
SGTC_3325 9138760 55.175 µM -1.13760852854335 0.134319559366671 no 2949 0.127641991902705 4163 43844959
SGTC_3154 9100113 49.47 µM -1.14089169354372 0.13358881620686 no 2950 0.126957498252533 4244 25237525
SGTC_3204 9114183 49.47 µM -1.14149055820592 0.13345582059546 no 2951 0.126832919444556 4220 17027248
SGTC_562 3772-2733 112 µM -1.14154011954951 0.133444818114955 no 2952 0.12682261326163 4215 2876874 YIL048W NEO1
SGTC_104 0074-0074 590.992 µM -1.14175471655551 0.133397185375714 no 2953 0.126777994968609 3995 3943124
SGTC_1635 st007035 42.4 µM -1.14485277576257 0.132710831879441 no 2954 0.126135074522352 4204 3716403
SGTC_2768 sulfasalazine 50.2 µM -1.14566549625074 0.1325311827461 no 2955 0.125966792802555 4217 5384001 An antioxidant and salicylic acid derivative.
SGTC_2635 hydroquinidine 100 µM -1.14674030128752 0.132293858123747 no 2956 0.125744484425838 4155 442912 An experimental heart treatment.
SGTC_1725 st036284 20.55 µM -1.1490981429757 0.131774256507845 no 2957 0.1252577570268 4294 707914
SGTC_777 1315-0167 517 µM -1.1507927898204 0.131401675064555 no 2958 0.124908745878789 4263 4221767
SGTC_1588 farnesol 29.9 µM -1.15286751394547 0.130946521780042 no 2959 0.124482383922546 4252 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_770 0389-1121 67.2 µM -1.15890301911809 0.129628650668886 no 2960 0.123247859071097 4339 6753108
SGTC_316 k060-0003 58.6 µM -1.15897184547978 0.129613675392094 no 2961 0.123233830720614 4287 6152314
SGTC_2937 9044753 11.33 µM -1.15993704601629 0.129403792774677 no 2962 0.12303721914915 4181 6465530 YGL099W LSG1
SGTC_714 4296-0578 26.1 µM -1.16226942642274 0.128897589758587 no 2963 0.122563020729078 4299 1589775
SGTC_1434 4073-0095 163 µM -1.16274959287007 0.128793548607177 no 2964 0.122465557019505 4236 24133745
SGTC_1547 harmine 94.2 µM -1.16872121018994 0.127504501356541 no 2965 0.121257986766376 4206 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1442 4112-3290 3 µM -1.17260036801879 0.126671959586686 no 2966 0.120478050885635 4252 704353
SGTC_1938 st074717 56.4 µM -1.18046831126421 0.124994992857078 no 2967 0.118907003347133 4153 17250979
SGTC_3064 1327-0027 10 µM -1.18227262267666 0.124612619469217 no 2968 0.118548772451139 4197 16000455 YPR107C YTH1
SGTC_1988 st071872 53.4 µM -1.1848718104133 0.124063232780631 no 2969 0.118034067281828 4305 16414116
SGTC_2076 5212012 200 µM -1.18875742512666 0.123245100153266 no 2970 0.117267568021755 4231 604802
SGTC_1648 st011736 69.8 µM -1.18954406879326 0.123079930226127 no 2971 0.117112820159154 4269 2855514
SGTC_1383 3049-0032 20.7 µM -1.19034167207907 0.122912617612161 no 2972 0.11695606410549 4339 712864
SGTC_3253 9135987 49.47 µM -1.19269848700893 0.122419162444979 no 2973 0.116493739203745 4273 4182430
SGTC_1172 0370-0043 85 µM -1.19349743207175 0.1222522002886 no 2974 0.116337308629969 4309 376585
SGTC_324 1315-0088 19.6 µM -1.19379230389922 0.122190618889696 no 2975 0.116279611454998 4243 6787421
SGTC_1815 st051655 58.2 µM -1.19474218507732 0.121992392611722 no 2976 0.116093887537168 4234 5984156
SGTC_1341 1486-1360 280 µM -1.1964970880995 0.121626764388289 no 2977 0.1157513171178 4270 3976547
SGTC_2104 5389443 200 µM -1.20677910435127 0.119500014947504 no 2978 0.11375861266146 4313 2244536
SGTC_2715 st079500 56.4 µM -1.20857578185912 0.119131096456912 no 2979 0.113412932646659 4261 28246688
SGTC_760 0568-0725 82.9 µM -1.21006346043933 0.118826234934965 no 2980 0.113127271381728 4318 3916171
SGTC_2478 5763493 32.33 µM -1.21441178564065 0.117938317901422 no 2981 0.112295258562775 4237 1365576 YLR208W SEC13
SGTC_1302 1159-0335 255 µM -1.21495707717831 0.117827302840855 no 2982 0.112191231308843 4317 649284
SGTC_2182 6325192 200 µM -1.22215169208985 0.116369482671553 no 2983 0.110825134081045 4294 736248
SGTC_34 0469-0683 81.75 µM -1.22420442682545 0.115955900329695 no 2984 0.110437559820004 4280 3690923
SGTC_3110 9122132 49.47 µM -1.22421816526261 0.115953135847204 no 2985 0.11043496916082 4377 918317
SGTC_1540 guanosine 70.6 µM -1.22741958392204 0.115310213824372 no 2986 0.109832464713725 4229 6802 Guanosine is a purine nucleoside
SGTC_2783 7738165 71.43 µM -1.22880688259493 0.115032399158169 no 2987 0.109572110208183 4302 17201110
SGTC_1377 2944-0135 198 µM -1.22909451881309 0.114974857949799 no 2988 0.109518184997109 4321 1894137
SGTC_1906 st060206 94.7 µM -1.22973950871006 0.114845903081627 no 2989 0.109397333435147 4337 5133468
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.23084051383375 0.11462601343175 no 2990 0.10919125980616 4301 803109
SGTC_1531 st059297 52.4 µM -1.2320684062845 0.114381135788203 no 2991 0.108961766014007 4335 7566702
SGTC_2738 aclarubicin 5.55 µM -1.23230266807536 0.114334459478841 no 2992 0.108918021766292 4312 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1297 1068-0111 14.1 µM -1.23322890840984 0.114150040310904 no 2993 0.108745186403281 4305 767057
SGTC_1871 st057448 67.3 µM -1.23430758093746 0.113935538276462 no 2994 0.108544156056768 4344 691747
SGTC_988 1497-1057 103 µM -1.23492092739804 0.113813697941786 no 2995 0.108429967023516 4293 3533044
SGTC_1509 1326-1131 80 µM -1.2397620783113 0.112855268894711 no 2996 0.107531704155592 4283 768313
SGTC_2096 5468907 200 µM -1.23992607177192 0.112822903417869 no 2997 0.107501369786747 4315 759785
SGTC_824 1304-0008 100 µM -1.24124785980315 0.112562279466349 no 2998 0.10725709978836 4357 768245
SGTC_2849 9019321 12.99 µM -1.24187270615044 0.112439225003964 no 2999 0.107141765901856 4346 16489627
SGTC_2158 5657123 3.6195 µM -1.24209952518728 0.112394580055104 no 3000 0.107099921868392 4296 2858827
SGTC_1552 6-methylflavone 10.6 µM -1.24795247807893 0.11124691658734 no 3001 0.106024230399902 4276 689013
SGTC_844 0330-0132 15.3 µM -1.24862324163771 0.111115929171722 no 3002 0.105901453745096 4369 2828079
SGTC_2149 5554786 194.827 µM -1.24870711177062 0.111099558695053 no 3003 0.105886109374493 4360 745063 YPR165W RHO1
SGTC_2683 piperine 63.03 µM -1.25431441594349 0.110008992960386 no 3004 0.104863873075802 4330 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1318 1280-3875 124 µM -1.25443301298332 0.109986010238985 no 3005 0.104842329745146 4330 373245
SGTC_1414 3917-0015 5.4 µM -1.25503827436474 0.109868771308692 no 3006 0.104732433015004 4333 6618702
SGTC_3022 9087993 49.47 µM -1.2578053919378 0.109333923852252 no 3007 0.104231072611853 4401 17173644
SGTC_2523 spermine 47.74 µM -1.26322567603077 0.108291679683947 no 3008 0.103254043947544 4358 1103 A DNA binding polyamine.
SGTC_1852 st056254 31.4 µM -1.26402465627363 0.108138653766315 no 3009 0.103110588657283 4286 442583
SGTC_3072 9116419 49.47 µM -1.27122224836184 0.106767137513169 no 3010 0.101824796869038 4368 17170162
SGTC_929 2805-0021 398 µM -1.27299920790581 0.106430474624942 no 3011 0.101509161466746 4399 3098024
SGTC_2159 5658611 73.75 µM -1.27520665709158 0.106013319550618 no 3012 0.101118052829754 4336 793844
SGTC_1036 k216-0215 33.5 µM -1.2772040656506 0.105636876437906 no 3013 0.100765106004825 4295 622330
SGTC_1234 0326-0494 15.5 µM -1.27763461689752 0.105555859050122 no 3014 0.100689144420569 4425 1547813
SGTC_1512 0259-0544 12.2 µM -1.27995127835807 0.105120701135177 no 3015 0.10028113579713 4319 18476
SGTC_94 0334-0113 514.748 µM -1.28410210484656 0.104344266487727 no 3016 0.0995531158431878 4359 6795178
SGTC_1211 1056-0033 32.3 µM -1.28599685857494 0.103991227383816 no 3017 0.0992220790160454 4404 6741922
SGTC_573 3702-0553 84.7 µM -1.28789357128426 0.103638691595824 no 3018 0.0988915068182107 4300 1222756
SGTC_2656 pseudo-anisatin 100 µM -1.28917294548867 0.103401388737334 no 3019 0.0986689841741685 4409 6708809 A neurotoxin.
SGTC_3345 9148410 3.559 µM -1.28949155182471 0.103342353896209 no 3020 0.0986136257453195 4299 4903596
SGTC_3079 9117512 49.47 µM -1.29116627520487 0.103032445281576 no 3021 0.0983230133290851 4424 7185044
SGTC_1326 1431-2094 10.8 µM -1.2936416236842 0.102575617637188 no 3022 0.0978946189925359 4351 616278
SGTC_204 PMA1.184 62.41 µM -1.29527333387676 0.102275290442366 no 3023 0.0976129773754736 4323 2252213 YGL008C PMA1
SGTC_2186 6124449 200 µM -1.29575245327481 0.102187226894193 no 3024 0.0975303918460866 4363 3834182 YLR033W RSC58
SGTC_1386 3228-0095 33.8 µM -1.30412360960653 0.100657475416104 no 3025 0.0960957201137216 4372 870181
SGTC_469 w7 172 µM -1.3050710740774 0.100485392918081 no 3026 0.0959343236542276 4457 45115570 A P450 inhibitor.
SGTC_497 capsazepine 133 µM -1.31054772743248 0.099494904935717 no 3027 0.0950053047087903 4322 2733484 A calcium channel blocker.
SGTC_1051 3253-3903 78 µM -1.31418535891156 0.0988409715269225 no 3028 0.0943919171620233 4370 5509239
SGTC_2492 derrusnin 100 µM -1.31518842901518 0.0986612050097634 no 3029 0.0942232914794808 4408 1715307 Part of coumarin class of compounds.
SGTC_2946 9065502 71.43 µM -1.31594110788045 0.0985264699276918 no 3030 0.0940969049611632 4217 16489101
SGTC_1994 st072947 40.9 µM -1.31831701435642 0.0981020489101997 no 3031 0.0936987738103942 4418 5286565 YDL195W SEC31
SGTC_1200 1643-0193 18.4 µM -1.32278061062858 0.0973083175404859 no 3032 0.0929541735133551 4403 5403974
SGTC_347 4534-1311 26.2 µM -1.32311636020394 0.0972488045346038 no 3033 0.0928983424339212 4385 2862016
SGTC_3235 9132602 49.47 µM -1.32507793492997 0.0969016410159865 no 3034 0.0925726518437547 4380 4912240
SGTC_1608 st001473 40.5 µM -1.32539381386081 0.0968458212815981 no 3035 0.0925202838594291 4326 7292267
SGTC_2934 9036370 36.88 µM -1.32974054911848 0.0960800955645852 no 3036 0.091801884889485 4364 6462800
SGTC_1989 st071868 50.2 µM -1.33074794990082 0.0959032678329037 no 3037 0.0916359798741907 4374 16414057
SGTC_1127 asiatic acid 681.4 nM -1.33752348313594 0.0947201823122274 no 3038 0.0905259110984283 4354 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2851 9015922 71.43 µM -1.33835488868837 0.0945757535696252 no 3039 0.0903903884786309 4413 2996893
SGTC_2887 9044784 58.44 µM -1.33857981359699 0.0945367083496183 no 3040 0.0903537506729108 4343 6465546
SGTC_1966 st070145 16.1 µM -1.33909947756252 0.0944465441629484 no 3041 0.0902691452758193 4375 3748532
SGTC_2748 diazoxide 86.69 µM -1.34203581128454 0.0939382673100971 no 3042 0.0897921922549291 4474 3019 A potassium channel activatior.
SGTC_85 0868-0259 160.055 µM -1.34388978784404 0.0936183869147047 no 3043 0.0894920144013634 4324 83173
SGTC_2947 9072639 7.68 µM -1.34648345618973 0.0931722326902263 no 3044 0.0890733261252378 4370 16488146
SGTC_234 nsc-17383 10.7 µM -1.34759056903888 0.0929822700322309 no 3045 0.0888950527798466 4414 408974
SGTC_2625 euphol 100 µM -1.34819746728083 0.0928782576776466 no 3046 0.0887974395073078 4398 6708538 A triterpene alcohol.
SGTC_835 0312-0010 67.2 µM -1.3507433798232 0.0924428675130772 no 3047 0.0883888255240941 4413 1626196
SGTC_970 1315-0089 19.5 µM -1.3521876436184 0.0921965485303243 no 3048 0.0881576477474572 4368 6811083 YLR033W RSC58
SGTC_1594 piperine 70.1 µM -1.35269489326036 0.0921101525608414 no 3049 0.088076561282313 4398 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_908 3448-7491 47.7 µM -1.35539132022317 0.0916518966703864 no 3050 0.0876464567918211 4418 1203031
SGTC_3233 9132340 49.47 µM -1.35569486471747 0.0916004154664018 no 3051 0.0875981370052825 4410 17682950
SGTC_2355 9061122 103.12 µM -1.35794839242584 0.0912188866290343 no 3052 0.087240030187131 4409 5302957
SGTC_110 0850-0284 111.64 µM -1.36122397677575 0.0906664235913357 no 3053 0.086721459624138 4300 3906265
SGTC_201 4262-0159 12.803 µM -1.36235420755145 0.09047637527466 no 3054 0.0865430639692854 4456 1341029
SGTC_3288 9119690 36.221 µM -1.36282870020906 0.0903966775379034 no 3055 0.0864682518507976 4403 17595618 YKL019W RAM2
SGTC_3139 9095020 49.47 µM -1.36407145099079 0.0901881870941167 no 3056 0.0862725394885572 4258 25236292
SGTC_1299 1079-1439 3.74 µM -1.36619196845492 0.0898332629454599 no 3057 0.0859393588633766 4393 323161
SGTC_473 2-arachidonoylglycerol 10 µM -1.36809501526829 0.089515623085515 no 3058 0.0856411684060085 4241 5282280 An endocannabinoid.
SGTC_2118 5526350 200 µM -1.37123132933972 0.0889939608934425 no 3059 0.0851514273717836 4435 743594
SGTC_2075 5212009 200 µM -1.37273217255641 0.0887451281022404 no 3060 0.084917811787857 4345 780898
SGTC_449 xestospongin c 11.1929 µM -1.37290223333316 0.0887169655330851 no 3061 0.0848913711056956 4436 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_485 niflumic acid 177 µM -1.37487320831351 0.0883910516716246 no 3062 0.0845853783311948 4450 4488 A COX2 inhibitor.
SGTC_3167 9103034 49.47 µM -1.37574807098383 0.088246673518676 no 3063 0.0844498218019534 4506 5127859
SGTC_965 1291-5240 308 µM -1.3770211632466 0.0880368898338319 no 3064 0.0842528524204818 4413 2834598
SGTC_1572 epiandrosterone 68.9 µM -1.38277839485242 0.0870928385784046 no 3065 0.0833664127855398 4363 441302 A steroid.
SGTC_513 4245-1575 41.7 µM -1.38282144588602 0.0870858078080016 no 3066 0.0833598107375856 4258 719745
SGTC_2252 omeprazole 400 µM -1.38540984932693 0.0866638677579417 no 3067 0.0829635905079909 4454 4594 A proton pump inhibitor.
SGTC_1644 st010134 20.9 µM -1.38567000905329 0.0866215433276857 no 3068 0.0829238450012707 4402 3818134
SGTC_3066 9117245 49.47 µM -1.38594989007334 0.0865760277656534 no 3069 0.0828811025993756 4470 17176980
SGTC_3042 9091578 49.47 µM -1.38784390574096 0.0862684838119954 no 3070 0.0825922909775276 4426 25236497
SGTC_77 0828-0286 12.516 µM -1.39272858842292 0.085479097174894 no 3071 0.0818509400685514 4326 745345
SGTC_3124 9127567 49.47 µM -1.39751398432204 0.0847110137670061 no 3072 0.0811295321782166 4391 17592030
SGTC_2164 5685496 200 µM -1.40093928362166 0.0841644200400555 no 3073 0.0806161151260569 4351 759046
SGTC_69 0096-0274 206.684 µM -1.40172502293633 0.0840394094518953 no 3074 0.0804986876795449 4525 6741392
SGTC_2719 novobiocin 32.65 µM -1.40817396312211 0.0830186503240182 no 3075 0.0795397820169697 4488 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2521 angolensin 13.4 µM -1.41336822928729 0.0822032878518442 no 3076 0.078773741032568 4479 821428 A flavenoid.
SGTC_1368 1852-0141 284 µM -1.41497294149257 0.0819526139914542 no 3077 0.0785382148561199 4431 2838987
SGTC_446 go6976 132 µM -1.41956921873978 0.0812378123235283 no 3078 0.0778665660069142 4472 3501 A protein kinase C inhibitor.
SGTC_1196 1588-0294 184 µM -1.42073737429298 0.0810568955354008 no 3079 0.0776965614630269 4481 6144269
SGTC_2938 9059746 27.26 µM -1.42154676302416 0.0809317208033372 no 3080 0.0775789344849133 4448 6471769
SGTC_1945 st075991 56.6 µM -1.42175128763993 0.0809001134799217 no 3081 0.0775492327092194 4426 1084980
SGTC_296 1222-0039 74.9 µM -1.42277444656222 0.080742133953974 no 3082 0.0774007756455373 4455 5984176
SGTC_261 5-fluorouridine 15.376 µM -1.42630021628572 0.0801995263484502 no 3083 0.0768908511084316 4470 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1539 benzyladenosine 56 µM -1.42703538851548 0.0800867331453873 no 3084 0.0767848472197753 4465 92208 A nucleotide analog.
SGTC_855 0428-0020 25 µM -1.42806851610464 0.0799284291160752 no 3085 0.0766360692290899 4467 6812414
SGTC_2905 7799065 20.05 µM -1.43055384003221 0.0795485774227391 no 3086 0.0762790624407635 4337 1296806
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.43296448507801 0.0791814460556327 no 3087 0.0759339935033111 4432 442882
SGTC_1193 1488-0126 41.5 µM -1.43315004960729 0.0791532386054401 no 3088 0.0759074804393585 4425 1384710
SGTC_120 rhodamine 6G 52.259 µM -1.43846272700006 0.0783488882032814 no 3089 0.0751514029068903 4470 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_533 1222-0222 6.71 µM -1.43946681996875 0.0781975652884783 no 3090 0.0750091521211912 4476 3982874
SGTC_2346 9031566 143.75 µM -1.44295625805232 0.0776734092809111 no 3091 0.0745163968429304 4430 4771086
SGTC_544 k015-0020 52.4 µM -1.44402644625157 0.0775131896447106 no 3092 0.0743657681719232 4482 3008304
SGTC_1529 apigenin 74 µM -1.44817063876385 0.0768951227283518 no 3093 0.0737846669343075 4463 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2659 sanguinarine 24.21 µM -1.44934162901816 0.0767211613276354 no 3094 0.0736211004723553 4417 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.4530066240365 0.0761786264778682 no 3095 0.0731109574267045 4423 6857784
SGTC_1419 3993-2473 62.6 µM -1.45361403184666 0.0760889937454157 no 3096 0.0730266722137256 4541 704026
SGTC_2373 9071805 200 µM -1.45847424463764 0.0753746806711897 no 3097 0.0723549346036771 4480 10149009
SGTC_1217 1183-1422 255 µM -1.46019527554948 0.0751229672093482 no 3098 0.0721182067007153 4497 2849664
SGTC_1265 0819-1001 68.8 µM -1.46479724179993 0.0744530444278509 no 3099 0.071488122315402 4411 3106768
SGTC_1212 0520-0165 585 µM -1.46860668545246 0.0739019500038169 no 3100 0.0709697502422578 4534 5403258
SGTC_1056 3448-1962 115 µM -1.47110884647492 0.073541673729286 no 3101 0.0706308414947002 4441 715507
SGTC_215 1287-0124 461.5 µM -1.47141238936123 0.0734980592899791 no 3102 0.0705898124396841 4505 5560863
SGTC_534 k292-0788 63.4 µM -1.47832499917769 0.0725101694170379 no 3103 0.0696604047351788 4528 4146317
SGTC_652 0437-0092 114 µM -1.47918916163972 0.0723873895303479 no 3104 0.0695448827293837 4437 3091274
SGTC_1726 st035556 14.5795 µM -1.47968838536478 0.0723165326331895 no 3105 0.0694782133159223 4509 5919439
SGTC_2097 5376186 200 µM -1.48051570480758 0.0721992247859243 no 3106 0.0693678363625632 4457 742755
SGTC_895 0964-0006 13.7 µM -1.48286616222234 0.0718667428746047 no 3107 0.0690549866375354 4485 6738897
SGTC_743 1275-0778 158 µM -1.48429061221948 0.0716658207118685 no 3108 0.0688659198730173 4460 2849257 YMR203W TOM40
SGTC_293 4049-0273 38.5 µM -1.48777849095483 0.0711756664807662 no 3109 0.0684046599293577 4362 1380311
SGTC_2584 androsterone 48.74 µM -1.48798247589641 0.0711470801916321 no 3110 0.0683777575838129 4388 2754130 A steroid.
SGTC_1345 1488-0192 31.4 µM -1.48855364251199 0.0710670842528522 no 3111 0.0683024732894776 4527 658348
SGTC_2641 levomentholum 100 µM -1.48945108579699 0.0709415305072626 no 3112 0.0681843123707378 4493 16666
SGTC_2837 9008476 45.46 µM -1.49064897699048 0.0707742092001522 no 3113 0.0680268392246325 4449 2992805
SGTC_217 ketoconazole 989 nM -1.49766652997261 0.0698000832580162 no 3114 0.0671099559645081 4295 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1447 4239-0816 81.9 µM -1.4985213700223 0.0696821290862967 no 3115 0.0669989223334173 4500 1341554
SGTC_1 0258-0098 57.368 µM -1.50374370422884 0.0689648604709655 no 3116 0.066323685704341 4405 6790032 YDR047W HEM12
SGTC_1749 st037932 54.2 µM -1.50543270212752 0.0687341047369235 no 3117 0.0661064333808434 4500 594497
SGTC_2675 theaflavin digallate 100 µM -1.50599296139314 0.0686576921543348 no 3118 0.0660344902779939 4431 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2208 7283366 200 µM -1.50700426373773 0.0685199286338061 no 3119 0.0659047821554022 4489 898663
SGTC_2948 9070189 9.45 µM -1.50946449741937 0.0681856764799324 no 3120 0.0655900607148561 4442 6473636 YDL196W YDL196W
SGTC_1581 himbacine 57.9 µM -1.51299823329069 0.0677077800774043 no 3121 0.0651400538104623 4510 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_255 tunicamycin 200.472 nM -1.51561795266557 0.0673551669266859 no 3122 0.0648079924347157 4424 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2001 4023502 57.655 µM -1.52060180058413 0.0666882639834753 no 3123 0.0641798973496412 4506 108941 YCR052W RSC6
SGTC_419 nsc-638432 893 µM -1.52152402388887 0.0665654208396191 no 3124 0.0640641936381663 4472 368090
SGTC_2968 9090663 33.37 µM -1.52565579904219 0.0660172041290636 no 3125 0.0635478039395431 4447 25236811
SGTC_2518 prenyletin 46.28 µM -1.52934087415175 0.0655312141833571 no 3126 0.0630899808583169 4537 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2134 5324836 1.464 µM -1.53638425436792 0.06461005303403 no 3127 0.0622220831029017 4490 699272
SGTC_427 1354-0053 47.3 µM -1.53818187838838 0.0643765712426027 no 3128 0.0620020752764359 4534 6813657
SGTC_1920 st075728 45.7 µM -1.53857572545536 0.064325504650622 no 3129 0.0619539542372981 4487 3400306
SGTC_341 1486-1430 230 µM -1.53881143339008 0.0642949575925813 no 3130 0.0619251689045411 4472 2054753 YPL210C SRP72
SGTC_3123 9126162 49.47 µM -1.54054659217017 0.0640704329426839 no 3131 0.0617135874374244 4520 25239884
SGTC_2564 betulinic acid 100 µM -1.54391794832224 0.0636359323069617 no 3132 0.061304105704793 4513 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.54589917943934 0.0633816626951259 no 3133 0.0610644593859337 4488 756377
SGTC_953 1188-0045 9.7 µM -1.5479903072424 0.0631141476402883 no 3134 0.0608123150918426 4499 6144426
SGTC_1492 4158-0558 28.5 µM -1.55201184265691 0.0626021507364375 no 3135 0.0603296949934859 4524 3967268
SGTC_2815 7968870 71.43 µM -1.55214998827458 0.0625846205835457 no 3136 0.0603131696988853 4443 2977326 YHR190W ERG9
SGTC_990 3985-0011 41.3 µM -1.55748950839355 0.0619099836230653 no 3137 0.0596771548004365 4488 5399565 YGL099W LSG1
SGTC_2757 clomiphene 4.22 µM -1.56362269679088 0.0611420871440042 no 3138 0.0589531007350478 4527 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_650 1328-0195 38 µM -1.56537398202216 0.0609241919114689 no 3139 0.0587476226594768 4538 2780821
SGTC_558 k064-0027 21.3 µM -1.56939871078427 0.0604257354101474 no 3140 0.05827753214046 4535 5088526
SGTC_2496 diffractaic acid 79.83 µM -1.57157443850432 0.0601576068684906 no 3141 0.0580246392131431 4519 94870 An apoptosis inducer which activates caspases.
SGTC_2242 6630449 61.2675 µM -1.57493581299805 0.0597451958984907 no 3142 0.0576356305705887 4547 691249 YDR170C SEC7
SGTC_1514 1189-1591 158 µM -1.57543499666831 0.0596841398232134 no 3143 0.0575780358413589 4540 767698 YMR146C TIF34
SGTC_381 3461-2219 42.7 µM -1.57703847684744 0.059488345917863 no 3144 0.0573933359759076 4513 2883159
SGTC_917 harmaline 728.087 nM -1.57973310231824 0.0591604513860565 no 3145 0.057084000747812 4456 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1736 st036774 51 µM -1.58192724290574 0.0588945065927118 no 3146 0.0568330904572515 4565 1272247
SGTC_2276 7947513 42.08 µM -1.58214287823523 0.0588684208276286 no 3147 0.0568084784925479 4467 2105100
SGTC_514 4466-0038 2.65 nM -1.58289048902436 0.0587780513060413 no 3148 0.0567232134560334 4324 5722064
SGTC_1525 8-methoxypsoralen 92.5 µM -1.58709106983266 0.0582723173800619 no 3149 0.0562460100749127 4560 4114 Related to psoralen; DNA damaging agent.
SGTC_2549 cedrol 20.94 µM -1.59224438606559 0.057656553955423 no 3150 0.055664901782595 4489 6708665 A sedative which affects the nervous system.
SGTC_2493 resveratrol 26.09 µM -1.59448266996114 0.0573907031724656 no 3151 0.0554139846200437 4503 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2126 5251174 33.877 µM -1.59484830109151 0.0573473673481258 no 3152 0.0553730814546019 4516 790722
SGTC_3328 9140624 29.0385 µM -1.6034501795084 0.0563352535498602 no 3153 0.0544176500218987 4529 4904392
SGTC_200 k038-0079 37.545 µM -1.60385407927971 0.0562880782492165 no 3154 0.0543731104452071 4553 3436683
SGTC_2253 7938677 135.83 µM -1.60436225478676 0.0562287678402113 no 3155 0.0543171129561095 4587 2301972
SGTC_1881 5652484 16 µM -1.60471094802019 0.0561880995101188 no 3156 0.0542787157319095 4529 2255129
SGTC_1424 4048-1941 275 µM -1.60901368683656 0.0556881747498965 no 3157 0.053806674439098 4617 X1424
SGTC_2356 9061756 188.97 µM -1.6178823230544 0.0546688278172883 no 3158 0.052843980250937 4583 20104043
SGTC_2213 7173844 200 µM -1.61966922294253 0.0544652411832825 no 3159 0.0526516754396375 4571 892728
SGTC_223 busulfan 5 mM -1.620386516991 0.0543836866755005 no 3160 0.0525746371768426 4546 2478 A DNA alkylator.
SGTC_1976 st070609 63.5 µM -1.62660339481178 0.0536808842042067 no 3161 0.0519106789296982 4507 682556
SGTC_2092 5303694 80.6725 µM -1.63174792676113 0.053104763979272 no 3162 0.0513662996025971 4575 1963699
SGTC_384 k007-0144 5.16 µM -1.63350189132864 0.0529094673855935 no 3163 0.0511817416343398 4530 6824886
SGTC_3097 9117246 49.47 µM -1.63450021762193 0.0527985626062572 no 3164 0.0510769302931816 4584 16423892
SGTC_2919 7978188 46.38 µM -1.63618940135776 0.0526113300930461 no 3165 0.050899976961042 4567 2980291
SGTC_3017 9080681 49.47 µM -1.64051220006392 0.0521345816452574 no 3166 0.0504493569552428 4580 16451914
SGTC_3315 9136395 68.55 µM -1.64149871213286 0.0520262645703033 no 3167 0.050346967099625 4556 16876844
SGTC_424 splitomicin 100 mM -1.64683688170746 0.0514432419941133 no 3168 0.0497957891504081 4548 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3212 9128307 49.47 µM -1.65128500860082 0.0509614070584313 no 3169 0.0493401959770655 4472 27243542
SGTC_2896 9052656 71.43 µM -1.65257470702723 0.05082237674977 no 3170 0.0492087246015687 4255 6469436
SGTC_1674 st016616 23.6 µM -1.65856048103667 0.050181055683442 no 3171 0.0486021953416636 4532 625830
SGTC_1233 0325-0408 14.2 µM -1.66024393799842 0.05000185571187 no 3172 0.0484326943968508 4597 12874
SGTC_3251 9135047 49.47 µM -1.66257819136154 0.0497542247704797 no 3173 0.0481984497980007 4610 17682963
SGTC_3034 9090421 49.47 µM -1.66995860567253 0.0489777001806452 no 3174 0.0474637768978195 4523 17173761
SGTC_1117 retinoic acid 1.10837 µM -1.66998966953006 0.048974452402291 no 3175 0.047460703758364 4614 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_3030 9087619 49.47 µM -1.68058510161959 0.0478766822051093 no 3176 0.0464217658198118 4574 25236973
SGTC_1501 4491-0275 38.4 µM -1.68177439037554 0.0477547019816157 no 3177 0.0463062982593627 4589 5104718
SGTC_566 0958-0068 16.5 µM -1.68590581119409 0.0473328926536116 no 3178 0.0459069712393586 4491 6815365
SGTC_135 0933-0004 26.348 µM -1.68738646245664 0.0471824500546631 no 3179 0.0457645325934306 4505 21230617 YGL099W LSG1
SGTC_2923 7992654 58.14 µM -1.68938458625408 0.046980037211495 no 3180 0.0455728764487693 4562 2985126
SGTC_3116 9124943 49.47 µM -1.6902129116514 0.0468963310744514 no 3181 0.0454936145389594 4566 41905195 YPL160W CDC60
SGTC_82 0054-0107 293.755 µM -1.69317431180421 0.0465980456576014 no 3182 0.0452111463414044 4562 3104697
SGTC_964 1287-0107 19.4 µM -1.70287549935979 0.0456315484892333 no 3183 0.0442956849901341 4575 51516812 YPR165W RHO1
SGTC_3276 9139060 49.47 µM -1.70515841449702 0.0454064678174038 no 3184 0.0440824417557446 4652 4870619
SGTC_1840 st055363 71 µM -1.71239288163175 0.0446990891217641 no 3185 0.0434121450014417 4610 676033
SGTC_3100 9120536 49.47 µM -1.72430737758568 0.0435534703945313 no 3186 0.0423261840778969 4516 16421196
SGTC_191 3914-0123 66.505 µM -1.72515934097466 0.0434724675441452 no 3187 0.0422493804020624 4662 3144412
SGTC_156 3474-0145 5.642 µM -1.72600775225927 0.0433919233147593 no 3188 0.0421730090416962 4525 2265471
SGTC_1829 berberine 14.4 µM -1.72766797019921 0.0432346585007705 no 3189 0.0420238845671574 4558 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1910 st062352 60.4 µM -1.72821770535856 0.0431826861733267 no 3190 0.0419746003002573 4523 2245730
SGTC_1435 4092-0789 56.7 µM -1.73038825204352 0.0429779739868118 no 3191 0.0417804656862992 4619 2248285
SGTC_3037 9091026 49.47 µM -1.73245736508719 0.0427835590791465 no 3192 0.0415960809255617 4482 25236398 YIL048W NEO1
SGTC_1500 4488-1866 171 µM -1.73521893305371 0.0425251889156296 no 3193 0.0413510171115679 4641 2900003
SGTC_3316 9136639 10.545 µM -1.74165747958281 0.0419277024125428 no 3194 0.0407841984903949 4600 4903665
SGTC_662 k832-1615 104 µM -1.74185436908903 0.0419095390391426 no 3195 0.0407669651257574 4626 5878478
SGTC_1030 k029-0042 36.7 µM -1.7422466373395 0.041873370652547 no 3196 0.0407326482437409 4587 6080581
SGTC_164 4100-3994 89.624 µM -1.74518022348242 0.0416036852166093 no 3197 0.0404767512928233 4581 4615967
SGTC_2225 6654152 15.4 µM -1.7471912029546 0.0414196294659751 no 3198 0.040302088586528 4558 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2038 4100038 30.985 µM -1.74732893308183 0.0414070478409122 no 3199 0.0402901485309058 4566 3596803
SGTC_3101 9120531 49.47 µM -1.74897061783527 0.0412573185553693 no 3200 0.0401480492234908 4578 24824904
SGTC_2787 5284540 71.43 µM -1.75334021550524 0.0408609288817427 no 3201 0.0397718131950489 4604 736958
SGTC_543 3844-1095 191 µM -1.75868967293121 0.0403798634763128 no 3202 0.0393151162056636 4621 4230703
SGTC_717 1532-0246 73.2 µM -1.75971183954552 0.0402884676228117 no 3203 0.0392283386777802 4610 9561992
SGTC_2167 5876490 200 µM -1.76357609444743 0.0399444667866167 no 3204 0.0389016877165987 4618 686534
SGTC_113 0099-0221 2.5 µM -1.76573476574111 0.0397533407641199 no 3205 0.0387201786414339 4577 89219
SGTC_1320 1313-0481 95.3 µM -1.77806644036194 0.0386757191890131 no 3206 0.0376964717210673 4585 6813365 YLR208W SEC13
SGTC_690 glyoxal 20.3 µM -1.78073371690444 0.0384457942921657 no 3207 0.037477981119911 4421 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1004 4084-0029 199 µM -1.78126416659521 0.0384002014878017 no 3208 0.0374346527334383 4621 716894 YLR208W SEC13
SGTC_669 0108-0021 26.2 µM -1.78230668714402 0.0383107239979276 no 3209 0.0373496164035059 4609 17201
SGTC_787 4152-0075 138 µM -1.78730446039242 0.0378841328795774 no 3210 0.0369441467574411 4656 9566539
SGTC_2755 lomerizine 42.69 µM -1.78814878369793 0.0378124487979066 no 3211 0.0368760033935007 4561 3949 A calcium channel blocker.
SGTC_3252 9135871 49.47 µM -1.79139947554529 0.0375374939431411 no 3212 0.0366146065180112 4642 17682838
SGTC_680 0417-1641 114 µM -1.79223233281782 0.0374673113147665 no 3213 0.0365478787152258 4643 2835990
SGTC_883 0850-0245 24.6 µM -1.79365659980749 0.0373475405387914 no 3214 0.0364339982563942 4650 6823229 YPR165W RHO1
SGTC_1814 st052110 31.539 µM -1.79979446487362 0.0368349626306182 no 3215 0.0359465491456481 4567 674163
SGTC_918 glabranin 770.725 nM -1.80468605863866 0.0364305933489269 no 3216 0.0355619113195035 4619 124049 Also referred to as licorice root.
SGTC_1499 4480-0877 67.3 µM -1.8078899684807 0.0361677127248818 no 3217 0.0353118136776052 4642 2861909
SGTC_2244 6635614 200 µM -1.80790621036265 0.036166384046767 no 3218 0.0353105495187965 4581 836499
SGTC_2645 abamectin 100 µM -1.80922180090698 0.0360588939294265 no 3219 0.0352082760107271 4581 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_809 3998-0021 90 µM -1.8160054652581 0.0355087810267894 no 3220 0.0346847668875346 4597 715485
SGTC_2170 morpholine 200 µM -1.81640706431055 0.0354764307680561 no 3221 0.0346539761753196 4665 121171 Reacts with secondary amines.
SGTC_2331 7980721 200 µM -1.8235294716224 0.0349066988435609 no 3222 0.0341116187942061 4594 2981221
SGTC_365 0121-0052 13.6 µM -1.82994349226765 0.0344000796522099 no 3223 0.0336291945100229 4607 3101739
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.83405358837539 0.034078626492736 no 3224 0.0333230199213438 4651 7104
SGTC_157 1348-1695 65.819 µM -1.84556673848353 0.0331913046994407 no 3225 0.032477569888755 4556 5380510
SGTC_628 1636-0253 16 µM -1.84690081556219 0.0330897286595134 no 3226 0.0323807582646689 4638 4456143
SGTC_46 0329-0187a 2.197 µM -1.85016939894927 0.0328419422939256 no 3227 0.0321445689943563 4632 46494817
SGTC_248 streptozotocin 5.23457 mM -1.85408257977967 0.0325473038165361 no 3228 0.0318636732704677 4676 5300 DNA alkylating agent.
SGTC_3196 9111891 49.47 µM -1.8599227685642 0.0321116315560736 no 3229 0.0314482267553303 4612 18891510
SGTC_3298 9116858 71.43 µM -1.86616675769116 0.0316511732155678 no 3230 0.0310090191851582 4674 2506942
SGTC_2764 methyldopa 94.69 µM -1.87297319843948 0.0311554668907175 no 3231 0.0305360430448975 4604 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_3181 9108277 49.47 µM -1.87905110895469 0.0307182631720331 no 3232 0.0301187574801718 4640 17097298
SGTC_986 1493-0483 84 µM -1.88026280496204 0.0306317121200238 no 3233 0.0300361349174227 4624 40079
SGTC_1650 st011916 45.8 µM -1.88434235027996 0.0303417948732067 no 3234 0.0297593411926383 4638 242528
SGTC_2686 alizarin 95.37 µM -1.88438213066859 0.0303389790705896 no 3235 0.0297566525808858 4625 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2712 st079126 47.7 µM -1.88721557342693 0.0301389738304777 no 3236 0.029565668239892 4656 3152970
SGTC_2798 7813637 45.45 µM -1.89859449601564 0.0293467436616819 no 3237 0.028808906323556 4644 956368
SGTC_1672 st016598 6.51 µM -1.90214500507377 0.0291031165919463 no 3238 0.0285761000851213 4627 4665860 YNL267W PIK1
SGTC_1207 2099-0101 141 µM -1.91154890726716 0.0284659527785748 no 3239 0.0279670390212027 4664 5837381
SGTC_3057 9095946 49.47 µM -1.91937019217156 0.0279448993382677 no 3240 0.0274687502571978 4688 24540043
SGTC_2955 9076254 12.21 µM -1.92030642141869 0.0278830635790521 no 3241 0.0274096028726954 4620 16459619
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.92753274933107 0.0274096065675671 no 3242 0.0269566353860986 4673 616764
SGTC_1884 5633444 25 µM -1.93511220823932 0.0269202355447455 no 3243 0.0264882638624492 4610 5724239
SGTC_2848 9016370 25.97 µM -1.935818725331 0.0268749929367098 no 3244 0.0264449533394343 4636 7894410
SGTC_1131 3454-3128 32.3 µM -1.93896874345037 0.02667404977471 no 3245 0.0262525721340854 4627 710982
SGTC_102 gallobenzophenone 83.616 µM -1.94047455858191 0.0265784363804079 no 3246 0.0261610215791842 4657 70837
SGTC_259 usnic acid 108.925 µM -1.95341591929427 0.0257684561371606 no 3247 0.0253851657029542 4683 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_393 acivicin 6.25 µM -1.97053159866832 0.0247290342869575 no 3248 0.0243887386091893 4562 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1006 4099-6547 255 µM -1.97114083417097 0.0246926937989363 no 3249 0.0243538845811663 4685 3146833
SGTC_442 cape 100 µM -1.98122279196711 0.0240977881565988 no 3250 0.0237831471630197 4693 5281787
SGTC_2568 diosmetin 100 µM -1.98269174805593 0.0240121228119453 no 3251 0.0237009359500295 4673 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1215 3852-0577 11.2 µM -1.99026467235169 0.0235745411874264 no 3252 0.0232808937261541 4688 2884876
SGTC_3225 9130819 49.47 µM -1.99941829240069 0.0230545954119306 no 3253 0.022781557178673 4649 4547121
SGTC_2766 oltipraz 83.91 µM -1.99983371782129 0.0230312292533316 no 3254 0.0227591111766834 4657 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_19 0279-0214 38.434 µM -2.00530737043723 0.0227252144608895 no 3255 0.0224650986837271 4733 3566274 YBR002C RER2
SGTC_2546 rhodinyl acetate 100 µM -2.01920017745607 0.0219638631440303 no 3256 0.0217332089488572 4652 6708682
SGTC_1465 k213-0056 144 µM -2.02150641181543 0.0218395851183041 no 3257 0.0216136846416696 4633 24048857 YMR208W ERG12
SGTC_305 1682-2595 20.8 µM -2.03302698196887 0.0212276247433832 no 3258 0.0210248985417516 4688 226033
SGTC_134 0269-0018 6.916 µM -2.03502708349719 0.0211228729166622 no 3259 0.0209240739565008 4659 4378915
SGTC_216 k038-0035 28.382 µM -2.0535762650548 0.0201720606302779 no 3260 0.0200083606591004 4668 4444231 YPR107C YTH1
SGTC_568 1193-0097 7.48 µM -2.05674050557801 0.0200135436400528 no 3261 0.0198555968248303 4513 3646150
SGTC_237 nikkomycin 200 µM -2.06275348236537 0.0197152262692427 no 3262 0.0195680278560973 4699 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2698 st077697 67.5 µM -2.06637422241238 0.0195374205672362 no 3263 0.0193965789985578 4664 3154499
SGTC_2379 9035213 200 µM -2.06711476502361 0.0195012225824666 no 3264 0.0193616705696406 4683 646551
SGTC_1686 st019653 115.5 µM -2.08285776218773 0.0187450714155516 no 3265 0.0186320953122285 4708 97252
SGTC_571 k831-0106 44.2 µM -2.09339437560548 0.0182530473098544 no 3266 0.0181569820445974 4630 4783639
SGTC_2006 4011487 200 µM -2.09439093557271 0.0182070862108434 no 3267 0.0181125847872547 4647 45595294
SGTC_1332 1480-0653 17.5 µM -2.09874924743861 0.0180072390199842 no 3268 0.0179195054545743 4707 5749438
SGTC_3266 9136860 49.47 µM -2.11166747526626 0.0174258363862982 no 3269 0.0173574903026598 4474 4871271 YPR165W RHO1
SGTC_1490 4089-0339 670 nM -2.11389885198219 0.017327051242015 no 3270 0.0172619536594402 4719 742542
SGTC_1032 k061-1018 98.7 µM -2.12029669026236 0.0170464607355976 no 3271 0.0169905163080311 4727 4005393
SGTC_3081 9117243 49.47 µM -2.12272940351655 0.0169407929149599 no 3272 0.0168882667978056 4672 45595589
SGTC_2233 sulbentine 40.3845 µM -2.12351069724048 0.0169069755172473 no 3273 0.0168555400294243 4713 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2872 9044037 25.97 µM -2.13127426168878 0.0165740637182426 no 3274 0.0165332770932384 4750 6465195
SGTC_2949 9072542 2.23 µM -2.13754225447195 0.0163093924222582 no 3275 0.0162769563833459 4664 16457352
SGTC_24 0417-1663 219 µM -2.13772053214889 0.0163019177465327 no 3276 0.0162697160315033 4722 4329390
SGTC_2243 6634756 200 µM -2.15267403482039 0.0156853165089322 no 3277 0.015672152757618 4705 885676
SGTC_1702 st027038 51 µM -2.15716254469847 0.0155041839742671 no 3278 0.0154965008642896 4745 5521182
SGTC_2969 9091408 28.7 µM -2.15867656702219 0.0154434923421658 no 3279 0.0154376339862612 4655 4286311
SGTC_288 1315-0019 35.1 µM -2.1656135023181 0.0151680172045254 no 3280 0.015170366864176 4729 6811474
SGTC_1448 4255-0083 152 µM -2.17313196974488 0.0148742264030003 no 3281 0.0148851930814009 4735 5399660
SGTC_713 1488-1073 324 µM -2.17624518128008 0.0147540150115032 no 3282 0.01476846607931 4730 3312542
SGTC_2229 7354935 190 µM -2.17791976013522 0.0146897003064547 no 3283 0.0147060055488573 4725 318112
SGTC_2612 dictamnine 15.46 µM -2.17797740289237 0.0146874907509285 no 3284 0.0147038595694262 4637 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1411 3909-8223 150 µM -2.18896560685181 0.0142714808837471 no 3285 0.0142996699497986 4756 X1411
SGTC_2172 5754775 163.918 µM -2.19428665682318 0.0140737017224104 no 3286 0.0141074040461802 4705 2263357
SGTC_806 3966-4455 5.86 µM -2.22179259182148 0.0130885689381171 no 3287 0.0131486628066944 4726 714982
SGTC_1766 st045414 44.774 µM -2.22191284647897 0.0130843963067148 no 3288 0.013144598031835 4726 253960
SGTC_552 k242-0005 476 µM -2.22270605343394 0.0130569021720036 no 3289 0.0131178137266318 4750 4088318
SGTC_682 0kpi-0099 17 µM -2.25106110102365 0.0121063223611095 no 3290 0.0121908338562206 4723 1714895 YML126C ERG13
SGTC_876 0720-0963 56.8 µM -2.25246445540445 0.0120608758461526 no 3291 0.0121464682456684 4738 765861
SGTC_3045 9092950 49.47 µM -2.25749100565506 0.0118993066385949 no 3292 0.0119887054396117 4713 44120432
SGTC_2464 5717415 7.67 µM -2.25882832352452 0.0118566385180169 no 3293 0.0119470329773181 4703 5285744
SGTC_1296 1068-0102 11.9 µM -2.27549616807982 0.0113358746472104 no 3294 0.0114380911450939 4747 767053
SGTC_230 MPP+ 141.667 µM -2.27879530454843 0.0112351878741915 no 3295 0.0113396180810057 4736 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1412 3909-8563 178 µM -2.27891191492939 0.011231643296971 no 3296 0.0113361510005162 4769 23767530
SGTC_696 1560-0013 611 µM -2.28004851610793 0.011197145193328 no 3297 0.011302405593085 4740 1650269
SGTC_808 0711-0032 135 µM -2.28741210950697 0.0109758693171745 no 3298 0.0110858900698216 4725 4252555
SGTC_1583 clindamycin 39.6 µM -2.29921022830416 0.0106292650953004 no 3299 0.0107465022432815 4734 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_392 N-ethylmaleimide 8.33 µM -2.30625545735357 0.0104268696695375 no 3300 0.0105481812237629 4727 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1968 st069590 43.6 µM -2.3166077439319 0.0101355652430088 no 3301 0.0102625545744241 4722 6384066
SGTC_44 0929-0055 61.211 µM -2.32314037953197 0.00995541867323571 no 3302 0.0100858061868617 4599 1379590
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -2.33630940898016 0.00960074375139738 no 3303 0.00973756074755135 4700 6708739 YPR165W RHO1
SGTC_1922 5578187 25 µM -2.35952680147272 0.00900228602822302 no 3304 0.00914912952104175 4718 1350412
SGTC_1452 4194-0072 190 µM -2.36240051000132 0.00893053391923145 no 3305 0.00907850714794171 4757 1343545
SGTC_336 4111-0029 111 µM -2.36703489560942 0.00881587579218826 no 3306 0.00896562102111673 4757 3131175
SGTC_53 0973-0023 39.979 µM -2.37970363025436 0.00850900164548011 no 3307 0.00866328349871175 4701 674768
SGTC_1043 0916-0009 19.3 µM -2.38359396225618 0.00841666676000606 no 3308 0.00857225353723725 4750 3101130
SGTC_817 1391-0715 46 µM -2.38486474061286 0.00838669669928222 no 3309 0.00854270093350106 4750 1353946
SGTC_436 n,n-dimethylsphingosine 3.3 µM -2.38776654785197 0.00831861141012553 no 3310 0.00847555281221565 4738 5282309
SGTC_2721 ifenprodil 61.44 µM -2.39434669355462 0.00816601651811934 no 3311 0.00832500115500348 4729 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_301 4119-0100 24.5 µM -2.40043292063175 0.00802707076893165 no 3312 0.00818784590557869 4763 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_794 k038-0031 316 µM -2.41388737513016 0.00772726548133867 no 3313 0.00789167011668245 4744 6624242
SGTC_1269 0831-0796 3.05 µM -2.42499829687542 0.00748715632647162 no 3314 0.00765422928575935 4750 927758
SGTC_1084 voriconazole 435 nM -2.42506175488393 0.00748580407884905 no 3315 0.00765289144818731 4770 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1710 st031758 61.5 µM -2.45437754226496 0.00688365074346631 no 3316 0.00705643616524049 4773 5394341
SGTC_177 1327-0068 8.361 µM -2.4654490391773 0.00666761794578281 no 3317 0.00684208196137521 4757 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_287 k060-0039 29.6 µM -2.48289142398872 0.00633942037590747 no 3318 0.00651604014232757 4771 5861974
SGTC_1929 genistein trimethyl ether 50.5 µM -2.49083116509035 0.00619482094174115 no 3319 0.00637223323445043 4749 136420
SGTC_457 grayanotoxin iii 135 µM -2.52622080131158 0.00558522831296304 no 3320 0.00576484959356062 4620 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_80 0159-0065 512.242 µM -2.53997477046827 0.00536308226173862 no 3321 0.00554302328289183 4769 1548079
SGTC_2043 5101342 149 µM -2.54515931919369 0.00528140526979837 no 3322 0.00546139448781288 4771 678451
SGTC_284 0988-0104 32.6 µM -2.54658301167812 0.00525917101966747 no 3323 0.00543916674797855 4751 4666532
SGTC_3175 9106517 49.47 µM -2.5645287288249 0.00498596302265945 no 3324 0.00516580129794646 4764 41468073
SGTC_2541 muurolladie-3-one 83.07 µM -2.57307113553128 0.00486041047596985 no 3325 0.0050400243596831 4751 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1600 coumarin 106 71.1 µM -2.58500691120103 0.00468970397339824 no 3326 0.00486885227412019 4774 100336 A hepatotoxic, DNA x-linker.
SGTC_2551 apiole 73.87 µM -2.58877772692397 0.0046368963914571 no 3327 0.00481586215136693 4749 10659 A possible DNA adduct former.
SGTC_304 1310-0298 97 µM -2.59619463634432 0.00453457371131608 no 3328 0.00471313258069114 4590 1550234
SGTC_1040 k898-0338 155 µM -2.62178714120116 0.00419680589453924 no 3329 0.00437350216684191 4755 20969351
SGTC_2258 7960471 200 µM -2.6322029066823 0.00406590997967202 no 3330 0.00424165906904475 4770 2974708
SGTC_3289 9119912 71.43 µM -2.64216316284344 0.00394416904545676 no 3331 0.00411891800439791 4766 17014829
SGTC_1967 st070177 51.4 µM -2.64621488458529 0.00389558768310673 no 3332 0.00406990454412242 4778 5729214
SGTC_12 0849-0099 9.267 µM -2.66346435406448 0.00369470727351414 no 3333 0.00386703027712778 4771 6071388
SGTC_2695 st077686 51.995 µM -2.68911469732363 0.00341315432736073 no 3334 0.00358208993973425 4750 2876092
SGTC_1685 st024049 53.0905 µM -2.73298905578466 0.00297596149526694 no 3335 0.00313812088725773 4789 1941139
SGTC_3009 9080819 71.4286 µM -2.73792040982455 0.00293011970450612 no 3336 0.00309145186450193 4783 17027216
SGTC_459 nigericin 15.3 µM -2.76274421643345 0.0027088833431051 no 3337 0.00286588322519928 4780 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2040 5100729 123 µM -2.769620877501 0.00265032406735131 no 3338 0.00280607877150617 4788 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_387 norethindrone acetate 66.7 µM -2.78147560033125 0.00255205238175475 no 3339 0.00270561990801918 4780 541197
SGTC_2039 Aminomethylbenzodioxan 200 µM -2.84917836977762 0.00205129303166833 no 3340 0.00219161494375371 4795 15053
SGTC_2976 9009005 19.48 µM -2.88151955950308 0.00184511168121007 no 3341 0.00197881335215197 4768 2993148
SGTC_776 4476-4378 112 µM -2.89122638701962 0.0017870125724915 no 3342 0.00191870789958654 4795 2892008
SGTC_2196 6573537 42.6665 µM -2.91380188831318 0.00165827146430184 no 3343 0.00178528209575085 4793 2903087
SGTC_180 1486-1293 102.781 µM -2.91981038459746 0.00162546058053028 no 3344 0.00175122210051328 4765 4140536
SGTC_2436 5633522 8.09 µM -2.97087985135736 0.00136956721792043 no 3345 0.00148473964458209 4783 5724242
SGTC_128 0906-2981 13.371 µM -3.1675932831851 0.000691139347348505 yes 3346 0.000768531947134489 4784 6740226
SGTC_432 NS 1619 61.3 µM -3.24216230350429 0.000527977560689979 yes 3347 0.000593132215559835 4786 4552 A K+/calcium channel activator.
SGTC_1678 st019265 80.2 µM -3.33889903356424 0.000369245243010932 yes 3348 0.00042055564954237 4786 5367020
SGTC_893 0958-0369 48.9 µM -3.3416850684856 0.000365411459124775 yes 3349 0.00041635741559689 4728 6819948
SGTC_3062 9077494 49.47 µM -3.45188284858425 0.00024032190533155 yes 3350 0.000278344687204743 4768 16459633
SGTC_1754 st042065 16.137 µM -3.56963437196922 0.000151527815337863 yes 3351 0.000178739908658944 4744 1126236 YIL048W NEO1
SGTC_2033 5192550 145 µM -3.61623440049695 0.00012576332954283 yes 3352 0.000149459859828692 4803 182073
SGTC_2297 7971671 152.32 µM -3.91139693847709 3.67136430675437e-05 yes 3353 4.58819065882307e-05 4799 909016
SGTC_178 4092-0806 87.505 µM -4.00135793992623 2.47884213098876e-05 yes 3354 3.14900011555101e-05 4786 2169044
SGTC_2296 7971656 126.45 µM -4.03637129244209 2.12273526408262e-05 yes 3355 2.71421418903803e-05 4803 666570
SGTC_2301 7769476 200 µM -7.1504470207899 1.40608015481202e-13 yes 3356 4.32478804601004e-13 4810 977820