SGTCid condition conc unit RSA4|YCR072C.score RSA4|YCR072C.strain.pval RSA4|YCR072C.strain.significant RSA4|YCR072C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1733 st037357 54.9 µM 4.13781326791552 4.10785149654365e-07 yes 1 1.75315771084241e-05 4 1272339 YGL099W LSG1 SGTC_198 3454-2873 16.191 µM 3.93782862807452 1.3574117258513e-06 yes 2 4.11111406990749e-05 4 710957 SGTC_3287 9117173 37.0625 µM 3.91711041324968 1.53152124479146e-06 yes 3 4.48083546860825e-05 2 2789709 SGTC_564 3555-0129 330 µM 3.86288820075998 2.09448753549401e-06 yes 4 5.60271490302938e-05 3 563260 SGTC_153 4077-0274 519.67 µM 3.78275613842717 3.30208085185731e-06 yes 5 7.75506769099111e-05 9 3121976 SGTC_665 3914-0008 307 µM 3.47738522367528 1.72669943779545e-05 yes 6 0.000253164889588678 5 1069549 SGTC_567 1080-0542 68.4 µM 3.3883595316308 2.73055350279541e-05 yes 7 0.000351560164932265 5 5950415 SGTC_876 0720-0963 56.8 µM 3.36893179819727 3.01343655456463e-05 yes 8 0.000377300491056764 12 765861 SGTC_1269 0831-0796 3.05 µM 3.34199139199509 3.45191009606201e-05 yes 9 0.000415898201211752 12 927758 SGTC_1382 3002-2117 298 µM 3.23619688309403 5.82904983381396e-05 yes 10 0.000605669013240707 8 1497314 SGTC_2608 thymoquinone 42.66 µM 3.19763155864945 7.02913479602475e-05 yes 11 0.000692805957570306 10 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2605 digitonin 300 nM 3.18622932214214 7.42630174934757e-05 yes 12 0.000720701476737614 11 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2791 5663188 71.43 µM 3.07503779680654 0.000125761312235383 yes 13 0.00105237939257049 23 54690634 SGTC_2285 7945142 200 µM 2.98708265997024 0.000188527455112179 yes 14 0.0014082677856301 23 2970608 SGTC_1284 0929-0043 16 µM 2.94231191898747 0.000230746260802904 yes 15 0.00162885804686923 14 1239883 SGTC_3299 9121982 43.1275 µM 2.87635818097602 0.000309232034995233 yes 16 0.00201146463110731 15 17594604 YPL160W CDC60 SGTC_2614 arthonioic acid 13.39 µM 2.85204045709649 0.000343973755114694 yes 17 0.00217197857580709 11 6710684 SGTC_588 3970-1144 52.9 µM 2.71525478256167 0.000616898346436116 yes 18 0.00331124000097897 5 1888707 SGTC_1332 1480-0653 17.5 µM 2.63534827644362 0.000857799421963192 yes 19 0.00420254963514488 15 5749438 SGTC_1206 3978-0017 132 µM 2.53461721804682 0.00128412955253543 no 20 0.0056285129059703 38 3873677 SGTC_2360 9040895 200 µM 2.52545189094229 0.00133125579896923 no 21 0.00577748005389556 25 4914414 SGTC_3297 9117502 71.43 µM 2.51223192499497 0.00140201779915397 no 22 0.00599851076232087 4 7453720 SGTC_147 4466-0538 29.23 µM 2.48910938365659 0.00153409269194426 no 23 0.00640317790771657 37 6742687 YHR072W ERG7 SGTC_2052 5265182 7.135 µM 2.45721469906802 0.0017349141596842 no 24 0.00700094889857328 30 1239884 SGTC_439 amiodarone 34.4 µM 2.45444001952761 0.00175346937327733 no 25 0.00705521010873141 29 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1575 cyproterone acetate 48 µM 2.44410597941917 0.00182417615959535 no 26 0.00726058009989612 28 9880 An androgen receptor antagonist and liver toxin. SGTC_164 4100-3994 89.624 µM 2.4341746807472 0.0018945605866951 no 27 0.00746289503399282 34 4615967 SGTC_751 0833-0568 350 µM 2.40258609207059 0.00213515144865158 no 28 0.00813980102648359 22 6954252 SGTC_353 1988-1175 58.3 µM 2.38243916363219 0.00230273651250858 no 29 0.00859918671803447 47 2788357 SGTC_3007 9078383 71.4286 µM 2.37412075541272 0.00237533888688112 no 30 0.00879539824649829 33 6496995 SGTC_1343 1487-0095 224 µM 2.35250229001553 0.00257381103936185 no 31 0.0093237874730989 27 4560101 YGL055W OLE1 SGTC_2182 6325192 200 µM 2.35233805859609 0.00257537451295187 no 32 0.00932790559685615 20 736248 SGTC_1867 st057372 64 µM 2.3518185880628 0.00258032549485069 no 33 0.00934094186572489 25 688837 SGTC_639 0833-0042 114 µM 2.33185815774578 0.00277720288232533 no 34 0.00985407715468989 40 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_987 1497-1013 404 µM 2.32878368480218 0.00280870406368322 no 35 0.00993526407698621 32 1676435 SGTC_761 k216-0224 480 µM 2.31569844543939 0.00294641249188275 no 36 0.0102873696772571 36 1340404 SGTC_554 4483-2211 187 µM 2.29331740904847 0.003196113391439 no 37 0.0109148688357226 24 747107 SGTC_1368 1852-0141 284 µM 2.28208556385587 0.00332846571444084 no 38 0.0112421445628916 34 2838987 SGTC_1143 3454-2408 5.08 µM 2.27241261498759 0.00344637549428246 no 39 0.0115308002460572 28 X1143 SGTC_2616 abietic acid 100 µM 2.23486772517709 0.00394039194785627 no 40 0.0127130169953078 34 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_3291 9121177 71.43 µM 2.23072280737909 0.0039986458434586 no 41 0.0128497479560585 22 17015612 SGTC_2851 9015922 71.43 µM 2.22469123700259 0.00408479311854802 no 42 0.0130509864754656 38 2996893 SGTC_1150 3909-7983 10.9 µM 2.19307819928084 0.00456405777477638 no 43 0.0141508727170265 62 23965914 SGTC_446 go6976 132 µM 2.18277385269722 0.0047307861175755 no 44 0.0145262340651435 32 3501 A protein kinase C inhibitor. SGTC_732 3970-1727 52.7 µM 2.18273638288443 0.00473140217845206 no 45 0.0145276144842195 39 1275699 SGTC_185 k048-0037 25.491 µM 2.18048333770457 0.00476857743739483 no 46 0.0146108263091346 19 6827589 SGTC_338 4055-0136 114 µM 2.17347979089457 0.00488580477794619 no 47 0.0148721126062636 29 2900563 SGTC_938 3126-1755 342 µM 2.16903447425082 0.00496153764161125 no 48 0.0150400333556988 20 1777771 SGTC_1675 st018485 24.5 µM 2.16609561556897 0.00501217816732944 no 49 0.0151519405904859 54 3323024 SGTC_1270 0831-1170 17.3 µM 2.16442735765699 0.00504112888785511 no 50 0.0152157830472953 39 6764716 SGTC_1286 0929-0070 131 µM 2.16190924572312 0.00508510991377099 no 51 0.0153125861024459 35 1420408 SGTC_973 1325-0077 65.9 µM 2.15139077843713 0.00527254025412551 no 52 0.0157226842196123 27 2835149 SGTC_161 4065-0411 162.148 µM 2.14216357730311 0.00544199499175755 no 53 0.0160901606525845 54 1906281 YLR208W SEC13 SGTC_1758 st042942 75.2445 µM 2.11229316167951 0.00602422943589679 no 54 0.0173306560166466 50 669317 SGTC_551 k048-0028 34.9 µM 2.10740383296942 0.00612461902452892 no 55 0.0175412948251835 58 6836383 SGTC_2744 captopril 92.04 µM 2.09419325995272 0.00640331423030533 no 56 0.0181213839729387 11 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_986 1493-0483 84 µM 2.08875804628951 0.00652119803779936 no 57 0.0183647543644127 37 40079 SGTC_1216 1165-0504 9.65 µM 2.08716316805614 0.00655615152218103 no 58 0.018436693810882 43 6304004 SGTC_1315 1237-0019 3.69 µM 2.0866888155413 0.00656657938845306 no 59 0.0184581364666458 41 825140 SGTC_2204 7233102 200 µM 2.08173948569342 0.00667626029007287 no 60 0.0186831359327069 34 2172480 SGTC_2175 5807670 165.306 µM 2.06979727087688 0.00694760175970799 no 61 0.0192356665312436 20 241186 SGTC_697 0508-1955 564 µM 2.05938383966271 0.0071921065694448 no 62 0.0197287413093012 39 6243113 SGTC_2160 5660466 132.927 µM 2.0556434122642 0.00728176584248845 no 63 0.0199084500355537 60 2859134 SGTC_866 0495-0101 262 µM 2.03778552962376 0.00772354513608549 no 64 0.0207856930680583 51 635694 SGTC_1657 st012939 43.4 µM 2.02686277165656 0.00800523807025108 no 65 0.021338224366076 28 24207257 SGTC_2809 7964133 12.99 µM 2.01850041489869 0.00822696500887488 no 66 0.0217695854991425 60 1253665 SGTC_1255 0566-0045 221 µM 2.01793772603717 0.00824207651591801 no 67 0.0217988736852645 64 2788469 SGTC_602 3130-1533 38.1 µM 2.00668954464731 0.00854931362222077 no 68 0.0223913649910473 64 720941 SGTC_2329 6138490 200 µM 1.98444278901668 0.00918668139647169 no 69 0.0236032499735611 62 720019 SGTC_1698 5-fluorocytosine 1.055 µM 1.97073606209672 0.00959976084093345 no 70 0.0243770367030037 67 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2935 9038016 29.96 µM 1.97000378116401 0.00962227936982201 no 71 0.0244189686060051 51 6463195 SGTC_1766 st045414 44.774 µM 1.96579940142369 0.00975246472558372 no 72 0.0246608934950978 62 253960 SGTC_480 am 92016 50 µM 1.96007975966455 0.00993203810334734 no 73 0.0249932342824332 58 2129 K+ channel blocker. SGTC_344 k064-0035 6.43 µM 1.95816426937187 0.00999281858566439 no 74 0.0251053701526689 51 5088750 SGTC_1364 1653-0028 37.6 µM 1.95515689404651 0.010088900763918 no 75 0.0252822773363616 39 5718652 SGTC_1383 3049-0032 20.7 µM 1.95397943781128 0.0101267381605111 no 76 0.0253518244856616 64 712864 SGTC_571 k831-0106 44.2 µM 1.9504429578092 0.0102411278043533 no 77 0.0255616729796238 59 4783639 SGTC_2311 7694451 200 µM 1.94499276698925 0.0104196242359647 no 78 0.0258879244248798 75 2163142 SGTC_2716 st080858 38.6235 µM 1.94242986779853 0.0105044937162932 no 79 0.0260425412217406 39 5296050 SGTC_2692 st077426 47.7 µM 1.94004735418632 0.0105839294119127 no 80 0.0261869675874906 71 25238571 SGTC_2123 5259487 200 µM 1.93816099286085 0.0106471935101802 no 81 0.0263017920335451 45 2173474 SGTC_2934 9036370 36.88 µM 1.93343981537547 0.0108069762721613 no 82 0.0265910202146948 47 6462800 SGTC_32 0928-0142 34.1 µM 1.93280502773393 0.0108286183271237 no 83 0.0266301103790596 62 2244242 SGTC_1997 st073024 93.8 µM 1.92939390451747 0.0109455622411462 no 84 0.0268409899298077 48 686268 SGTC_2027 5150920 200 µM 1.92763265085774 0.0110063725407915 no 85 0.0269504173202438 39 786715 SGTC_1170 0310-0127 64.8 µM 1.91992414811478 0.0112759926182432 no 86 0.0274337405969352 64 774975 SGTC_18 0111-0177 500 nM 1.91858425434053 0.0113234391013342 no 87 0.0275184849352871 60 721752 SGTC_1033 k072-0102 21.3 µM 1.91635324733823 0.0114028254539689 no 88 0.027660073744869 50 5965931 SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.90983572592637 0.0116375155159196 no 89 0.0280771839001845 50 5282309 SGTC_2282 7944268 200 µM 1.9043386000939 0.011838710968513 no 90 0.0284330500662197 60 2970414 SGTC_1201 1889-3372 45.9 µM 1.90293411175965 0.0118905969038997 no 91 0.0285245716044591 60 5392199 SGTC_1521 st012942 49.4 µM 1.90250784261697 0.0119063835127295 no 92 0.0285523972713783 57 24207259 SGTC_3296 9122258 64.045 µM 1.90115939439142 0.0119564422246685 no 93 0.0286405689543366 49 4730474 SGTC_1406 3909-7906 11.9 µM 1.88217788976812 0.0126807035747096 no 94 0.0299059333142422 54 X1406 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.86981673402857 0.0131725102734972 no 95 0.0307546358733684 60 5357218 A potent inhibitor of glutathione S-transferases. SGTC_606 k015-0008 38.6 µM 1.86600255850927 0.0133275529406975 no 96 0.0310205037702403 59 1970475 SGTC_2125 5246583 200 µM 1.86457062159495 0.0133861654406501 no 97 0.0311208070044096 69 835267 SGTC_1748 st037455 53.6035 µM 1.86218732329216 0.0134842129612032 no 98 0.031288345324741 74 580690 SGTC_297 0986-0032 24 µM 1.85971353170512 0.0135866384468821 no 99 0.0314630332602058 64 2847425 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.85549275822932 0.0137629468583333 no 100 0.0317629462030894 61 689007 SGTC_829 1635-0120 117 µM 1.84684123975984 0.014130511038815 no 101 0.0323850764906335 106 285054 SGTC_333 3486-0131 40.1 µM 1.84384599968196 0.0142597215613467 no 102 0.0326027933689482 63 6744690 SGTC_2157 5649910 96.377 µM 1.83381020216474 0.0147000962211157 no 103 0.0333410863943459 59 2858091 SGTC_530 4358-1714 28 µM 1.8283769152068 0.0149433563019486 no 104 0.0337465017509106 84 1564641 SGTC_500 h-89 112 µM 1.81775607443895 0.0154288809292056 no 105 0.0345507115066995 72 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1071 trifluoperazine 6.31 µM 1.81415438768099 0.0155965761776616 no 106 0.0348269801027794 62 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2237 6667747 47.222 µM 1.80967464496871 0.0158073343223574 no 107 0.0351731283564242 58 729940 YDL015C TSC13 SGTC_3017 9080681 49.47 µM 1.80425082296462 0.0160657731688465 no 108 0.0355959976340731 55 16451914 SGTC_427 1354-0053 47.3 µM 1.80091521489422 0.0162265026290037 no 109 0.0358581222466413 50 6813657 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.79644779318773 0.0164439260470627 no 110 0.0362116643105199 68 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_539 4859-0462 2.54 µM 1.79553268084179 0.016488769809908 no 111 0.0362844353392446 85 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1618 st003135 44.5 µM 1.79475421957633 0.0165269995488774 no 112 0.0363464338741485 62 1270615 SGTC_1176 0848-0131 83.3 µM 1.79200931432876 0.0166624060950251 no 113 0.0365657370016659 60 6769040 SGTC_1494 4358-1428 177 µM 1.78663284884928 0.0169303799437281 no 114 0.0369984244396985 69 1564571 SGTC_2994 9053520 71.4286 µM 1.78573001774439 0.0169757383076817 no 115 0.0370714913048587 58 4647384 SGTC_765 1319-0117 244 µM 1.785362679284 0.0169942231571812 no 116 0.0371012540442803 65 3487746 YGL099W LSG1 SGTC_1507 4075-3230 155 µM 1.78117572755176 0.0172061335533486 no 117 0.0374418738006681 43 659771 SGTC_861 0443-0273 110 µM 1.77701616924807 0.0174188890271788 no 118 0.0377827897627886 71 6149169 SGTC_2078 5212016 200 µM 1.76803676773746 0.0178858420957883 no 119 0.0385273785733207 59 1899708 SGTC_2424 5537928 59.2 µM 1.73290952374095 0.0198164689218833 no 120 0.0415558756328401 79 5382802 SGTC_618 k072-0232 33.2 µM 1.72506346398668 0.0202710698041865 no 121 0.0422580179849621 83 5872756 YGL099W LSG1 SGTC_1909 st060837 51.5 µM 1.72133758447611 0.0204900247943428 no 122 0.0425947915517104 73 678937 SGTC_203 k066-0004 30.888 µM 1.70716984816563 0.0213409915546559 no 123 0.0438952437740976 88 6795412 SGTC_97 0535-0701 19.132 µM 1.70657001350588 0.0213776696208578 no 124 0.0439510013373715 72 2832013 YGL099W LSG1 SGTC_416 estradiol valerate 100 µM 1.70484673141184 0.0214833397194261 no 125 0.0441115066628953 77 13791 A steroid. SGTC_152 4469-0003 551.229 µM 1.69461498608915 0.0221198741990693 no 126 0.0450742411539331 121 697280 SGTC_1787 fluconazole 80 µM 1.68695209447323 0.0226069567253055 no 127 0.0458062819256779 79 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_559 1550-0661 158 µM 1.67842182990584 0.023159776789889 no 128 0.0466323894743336 68 5830875 SGTC_2058 5236698 133 µM 1.67734256906596 0.0232305247591406 no 129 0.0467377564112613 67 766665 SGTC_522 1273-0010 11.6 µM 1.67697761311109 0.0232544895646617 no 130 0.0467734298060161 90 5705015 SGTC_933 2914-0560 114 µM 1.67589765653964 0.0233255267647887 no 131 0.0468791204200464 75 463887 SGTC_685 1278-0033 54.9 µM 1.67466253999434 0.0234069938377433 no 132 0.047000230573559 85 3590572 SGTC_435 c-PAF 6.7 µM 1.66919335407759 0.0237706189091346 no 133 0.0475395333937937 81 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2126 5251174 33.877 µM 1.66588819703192 0.0239926597117504 no 134 0.0478678424558172 83 790722 SGTC_12 0849-0099 9.267 µM 1.65685814029414 0.0246082020789167 no 135 0.0487740795579267 87 6071388 SGTC_3344 9148862 3.898 µM 1.64842458030243 0.0251949978369569 no 136 0.0496327877232803 69 4905352 SGTC_1649 st011737 51.3 µM 1.63788370128509 0.0259448614851779 no 137 0.0507229782863695 78 1761035 SGTC_2430 5571206 200 µM 1.63730362046806 0.0259866639819713 no 138 0.0507835224105702 102 1731771 SGTC_863 0466-0191 129 µM 1.63404481584214 0.0262225526233991 no 139 0.0511247203792508 107 765160 YPR165W RHO1 SGTC_608 k048-0125 159 µM 1.63401441204399 0.0262247618042133 no 140 0.051127912235414 75 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1079 idarubicin 2.36 µM 1.63224095557184 0.0263538930559423 no 141 0.0513143680701359 81 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2184 6075246 200 µM 1.61957904367499 0.0272913745717362 no 142 0.0526613671396612 67 2267320 SGTC_2351 9026858 72.31 µM 1.61430989131229 0.0276896147310294 no 143 0.053230112842981 98 1409300 SGTC_1792 st045773 43.6 µM 1.60305303679465 0.0285566422185784 no 144 0.0544614726064781 26 2919270 SGTC_1407 3909-7909 12.3 µM 1.60066541586205 0.0287434156976041 no 145 0.0547255224989009 67 4411780 SGTC_1971 st069429 63.5 µM 1.59836481846285 0.0289243414581897 no 146 0.0549809047923366 53 1246522 YGL099W LSG1 SGTC_1426 4048-4480 71.7 µM 1.59561623758585 0.0291417379231727 no 147 0.0552872499995549 70 14224343 SGTC_2879 9041815 71.43 µM 1.59420021110069 0.0292542659842248 no 148 0.0554455996320308 44 4942971 SGTC_1324 1418-0026 34.4 µM 1.59364996711334 0.0292980897458836 no 149 0.0555072281479762 77 1372513 SGTC_2959 9079155 11 µM 1.59257978178628 0.0293834799822726 no 150 0.0556272460786506 100 16189457 SGTC_210 3551-0445 56.827 µM 1.59220518177219 0.0294134181536507 no 151 0.0556693046581026 79 2865180 YOR207C RET1 SGTC_1379 2144-0755 36.5 µM 1.59193965313548 0.0294346546354355 no 152 0.0556991323396855 88 5392327 SGTC_637 1181-0519 7.26 µM 1.58752982625282 0.029789209538654 no 153 0.0561963486408518 96 6252091 YGR060W ERG25 SGTC_2303 7774051 200 µM 1.58570750238835 0.0299367574284752 no 154 0.0564028382511823 92 2953184 SGTC_3246 9135460 32.98 µM 1.58481898349478 0.0300089175478981 no 155 0.0565037339858699 84 41446951 SGTC_1636 st007707 68.9 µM 1.57961126772371 0.0304347622947087 no 156 0.0570979586205621 80 403051 SGTC_1460 k062-0059 9.15 µM 1.577886606507 0.0305768899428488 no 157 0.0572958312350761 79 1373085 SGTC_1654 st012436 41.8 µM 1.57472830269784 0.030838587716177 no 158 0.0576595859867365 51 4323132 SGTC_2551 apiole 73.87 µM 1.56565265669031 0.0316009338451659 no 159 0.0587149776977438 70 10659 A possible DNA adduct former. SGTC_199 4063-0024 41.6 µM 1.56354488043276 0.0317801962134338 no 160 0.0589622439859688 43 306215 SGTC_3209 9113616 49.47 µM 1.56057414512859 0.0320342773120715 no 161 0.0593121315348346 105 16649353 SGTC_1135 dihydrocapsaicin 536.708 nM 1.5564266574366 0.0323918070796997 no 162 0.0598033351786732 89 107982 A Capsaicinoid. SGTC_2289 7946404 165.07 µM 1.55542061463732 0.0324790263360446 no 163 0.0599229638141468 114 1246120 YPR165W RHO1 SGTC_346 4513-0042 7.16 µM 1.5509265435327 0.0328710104292953 no 164 0.0604596442611802 100 2827372 SGTC_474 dl-dihydrosphingosine 5 µM 1.54536772620207 0.0333612507187946 no 165 0.0611286710777248 95 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2327 6189656 200 µM 1.54267004773291 0.0336013239815661 no 166 0.061455426380331 82 5349088 SGTC_2469 5655019 90.81 µM 1.54145879154442 0.0337095783580132 no 167 0.0616025824153055 77 2788239 SGTC_1059 3448-6867 171 µM 1.53948167762689 0.0338868966635542 no 168 0.0618433737823212 107 3934407 SGTC_2195 6536160 144.242 µM 1.53731121936847 0.0340824378499822 no 169 0.0621085576755176 80 3834386 SGTC_1650 st011916 45.8 µM 1.52939005044488 0.0348039592939989 no 170 0.0630838887527193 92 242528 SGTC_527 4476-4215 268 µM 1.52224810738384 0.0354652092911453 no 171 0.0639734625907501 71 4418754 SGTC_2369 9071472 200 µM 1.52047111544636 0.0356313260464693 no 172 0.0641963064619527 72 17296037 SGTC_3340 9146634 11.102 µM 1.51706454362945 0.0359515623672464 no 173 0.0646251945298491 75 4907387 SGTC_1721 st082152 9.2685 µM 1.51645792993861 0.0360088339081914 no 174 0.0647018002176168 91 5296051 SGTC_2861 9024595 19.48 µM 1.51455178080533 0.0361892835347605 no 175 0.0649429756261675 51 16482810 SGTC_2338 7999974 200 µM 1.51273906369943 0.0363615744061722 no 176 0.0651729763770286 106 315925 SGTC_1908 st060353 56.5 µM 1.50185289904849 0.0374104300420132 no 177 0.0665675515656109 115 4227716 SGTC_548 1436-0017 110 µM 1.49030377343818 0.0385500414265716 no 178 0.0680721903871263 89 9677137 SGTC_2035 5154463 94.595 µM 1.48441583495872 0.0391418323949321 no 179 0.0688493182031139 120 2769623 SGTC_1916 st067606 49.2 µM 1.48269901665104 0.0393157738899906 no 180 0.0690771980111257 124 19590279 SGTC_219 mitoxanthrone 164.414 µM 1.47743620352285 0.0398529047279513 no 181 0.0697793737785313 102 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2545 solidagenone 89.61 µM 1.47475579537041 0.0401287553817265 no 182 0.0701391047596747 55 6708572 An anti ulcer agent SGTC_159 3970-0959 50 µM 1.47426483450035 0.0401794496661628 no 183 0.070205149709912 132 6615653 SGTC_2767 sibutramine 71.45 µM 1.47354889742332 0.0402534671564999 no 184 0.0703015445861279 77 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1158 4092-0494 91.8 µM 1.46370129822193 0.0412828483443404 no 185 0.0716377903214214 81 1148199 SGTC_281 1672-3440 14.9 µM 1.46140274132447 0.0415261654056241 no 186 0.0719524744223348 105 6833000 SGTC_862 0452-0056 10.2 µM 1.45704118138003 0.0419910583538135 no 187 0.0725525064621408 72 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_623 k072-0108 16.9 µM 1.45696203625649 0.0419995330894622 no 188 0.0725634299770541 116 5382803 SGTC_845 0330-0138 4.51 µM 1.45530498648168 0.0421772855527048 no 189 0.0727924233924918 112 9039800 SGTC_2273 7815444 169.05 µM 1.45474657032805 0.0422373240653625 no 190 0.0728697173631144 112 2824616 SGTC_169 k015-0017 16.025 µM 1.45438235835698 0.042276519822066 no 191 0.0729201641279588 104 1840002 SGTC_2024 5144227 134 µM 1.45375359623175 0.04234425518335 no 192 0.0730073164703882 91 3475211 SGTC_1169 aniline yellow 25.8 µM 1.45238322555926 0.0424921868330739 no 193 0.0731975389241323 97 6051 A DNA damaging agent. SGTC_406 estrone 100 µM 1.44794009603855 0.0429746996433357 no 194 0.0738169023430958 96 5870 A steroid. SGTC_3253 9135987 49.47 µM 1.44479982539755 0.0433183880077394 no 195 0.0742570600777103 107 4182430 SGTC_2803 7707263 71.43 µM 1.4432923070297 0.0434841657241133 no 196 0.0744690729861599 87 2199229 SGTC_747 3448-8087 38.7 µM 1.43972709091498 0.0438782609554632 no 197 0.0749723128303296 100 5168703 SGTC_817 1391-0715 46 µM 1.43657517688838 0.0442290648808599 no 198 0.0754193705628532 130 1353946 SGTC_218 alverine citrate 93.75 µM 1.43652469292471 0.0442347020214354 no 199 0.0754265475476049 109 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1739 st037196 92.5 µM 1.43433216206961 0.0444800836773568 no 200 0.075738748197937 80 612214 SGTC_835 0312-0010 67.2 µM 1.43358593099707 0.044563849402175 no 201 0.0758452303642515 108 1626196 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.43266590375711 0.0446672989111633 no 202 0.0759766689658641 87 521171 SGTC_467 ro 31-8220 72.8 µM 1.4297219347704 0.0449996242634352 no 203 0.0763984210965753 110 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2866 9034245 58.44 µM 1.42937361406964 0.0450390752223914 no 204 0.0764484390326066 83 6462273 SGTC_25 0118-0223 35.662 µM 1.42751649436781 0.0452498835128466 no 205 0.0767155371305408 87 5333628 SGTC_645 0845-0943 5.41 µM 1.42293761195091 0.0457730411918964 no 206 0.0773771208428232 103 1885106 SGTC_799 1310-0557 151 µM 1.41955621578747 0.0461624925801836 no 207 0.0778684599458334 115 5354492 SGTC_2114 5491910 81.25 µM 1.41485984430524 0.0467078058711565 no 208 0.0785547968065758 109 2849228 SGTC_728 3030-5151 22.5 µM 1.41098175458829 0.0471619909342108 no 209 0.0791249969732487 90 3125388 SGTC_101 0490-5701 117.494 µM 1.40504519914843 0.04786410536719 no 210 0.0800039190869348 82 4661669 SGTC_1783 st039459 87.517 µM 1.40339807087775 0.0480603865949587 no 211 0.0802490839721573 116 729761 SGTC_2703 st077852 53.4 µM 1.40305597576364 0.0481012332820414 no 212 0.0803000738552269 121 6281836 SGTC_1262 0737-0114 49.6 µM 1.39928006166604 0.0485539312004344 no 213 0.0808645081086617 122 765919 SGTC_2819 7996655 46.38 µM 1.39319729810997 0.0492903569467776 no 214 0.0817800683000003 80 6456960 SGTC_1531 st059297 52.4 µM 1.38637028316136 0.0501274804612351 no 215 0.0828169328582124 117 7566702 SGTC_1061 3448-9325 110 µM 1.3860261753129 0.0501699729336065 no 216 0.0828694554726052 119 723482 SGTC_2693 st077581 40.7 µM 1.38338696681944 0.0504968334188694 no 217 0.0832731223299211 108 25238761 SGTC_882 0843-0131 351 µM 1.3810496774604 0.0507877163464511 no 218 0.0836318433818544 140 5425421 SGTC_3039 9090270 49.47 µM 1.37760987785619 0.0512182350641898 no 219 0.0841618847666805 92 17173750 SGTC_1445 4239-0156 97.7 µM 1.37672958345776 0.0513288763538338 no 220 0.0842979343846781 105 4008346 SGTC_2999 9069765 71.4286 µM 1.37226049179922 0.0518935174156881 no 221 0.084991180001041 98 2097066 SGTC_930 2810-3379 265 µM 1.36833499705374 0.0523935402417558 no 222 0.0856036204724931 125 1015764 SGTC_3298 9116858 71.43 µM 1.36712500910118 0.0525484353236984 no 223 0.0857930627779031 130 2506942 SGTC_1641 st009299 47.1 µM 1.36311995403755 0.0530637312807055 no 224 0.0864223545131779 119 4046054 SGTC_2365 9042475 200 µM 1.36310998211137 0.0530650192651995 no 225 0.0864239256414756 112 6464479 SGTC_2412 st077135 33.4 µM 1.35983550556654 0.053489296405775 no 226 0.0869409919557291 110 13258915 SGTC_657 3534-0529 86.7 µM 1.35821115360149 0.0537007603714893 no 227 0.0871983462157088 114 1049549 SGTC_3249 9135183 49.47 µM 1.35319899474507 0.0543574370839056 no 228 0.0879960331683445 111 4902779 SGTC_190 3970-0790 3.722 µM 1.34881311281839 0.0549372580515845 no 229 0.0886985008937306 107 2832352 SGTC_3170 9103054 49.47 µM 1.34764463839716 0.0550925540103084 no 230 0.0888863530454254 115 16432970 SGTC_456 gingerol 170 µM 1.34526624444858 0.0554097254834241 no 231 0.0892696351401786 113 442793 A herb. SGTC_1611 st001856 99.4 µM 1.34341015467954 0.0556582451177017 no 232 0.0895696002791218 127 647478 SGTC_2834 9001755 58.44 µM 1.33343081344131 0.0570095335765514 no 233 0.0911952330450495 124 2989575 SGTC_2094 5332512 191.667 µM 1.32851633986726 0.0576844209661292 no 234 0.0920037946180094 119 755774 SGTC_2989 9073649 71.4286 µM 1.32789255549126 0.0577705305575102 no 235 0.0921068022115424 143 21367202 SGTC_672 1441-0018 53.7 µM 1.32557478447905 0.0580913702675719 no 236 0.0924902915246365 104 251141 SGTC_2967 9089538 49.85 µM 1.32503531921576 0.0581662467703921 no 237 0.0925797185676955 140 728216 SGTC_33 0986-0033 35.816 µM 1.32449789940845 0.0582409147446784 no 238 0.0926688701189338 86 2848082 SGTC_2181 6316240 54.2555 µM 1.32390070367388 0.0583239761651616 no 239 0.092768012251811 98 12779990 SGTC_222 nsc-310342 10.666 µM 1.32187416192869 0.058606533009789 no 240 0.09310502880915 102 432556 SGTC_1081 sertraline 6 µM 1.31055140250354 0.0602050669291918 no 241 0.095004683529885 134 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1341 1486-1360 280 µM 1.30991807612708 0.0602954773697521 no 242 0.0951117756965718 123 3976547 SGTC_3207 9114163 49.47 µM 1.30867074936245 0.0604738500824409 no 243 0.0953229520400322 152 849233 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.30669930668627 0.0607566159418885 no 244 0.0956574271249259 138 616764 SGTC_2627 acetyl isogambogic acid 100 µM 1.30454146117705 0.0610673018856395 no 245 0.0960245163224307 119 6857789 A caspase activator and apoptosis inducer. SGTC_807 1315-0151 48 µM 1.30327276300473 0.0612505475169469 no 246 0.0962408281965156 163 4011080 SGTC_825 1988-2224 89.6 µM 1.30191657720036 0.0614469043237573 no 247 0.096472452474144 137 1180859 SGTC_1508 1080-0625 72.9 µM 1.29948652163827 0.0617999719354329 no 248 0.0968885080211558 122 767111 SGTC_1746 st038117 42 µM 1.29651461481715 0.0622339165376037 no 249 0.0973991241203929 126 2898218 SGTC_1129 3453-1384 223 µM 1.29337133979445 0.0626954659655356 no 250 0.0979413288307002 130 1084452 SGTC_1913 st060213 96.1 µM 1.29227275748982 0.0628574062767634 no 251 0.0981313514073198 134 688959 SGTC_2986 9022445 71.43 µM 1.29144265401428 0.0629799865636483 no 252 0.0982751140582655 140 6459286 SGTC_2531 methyl deoxycholate 70.07 µM 1.2903661820544 0.0631392249763654 no 253 0.098461774035785 127 16667744 Haematoxylin. SGTC_943 3253-1379 105 µM 1.28402846684638 0.0640831042231771 no 254 0.0995659975836047 142 668464 SGTC_2689 tacrolimus 100 µM 1.28376547800796 0.0641225070594725 no 255 0.0996120130397217 123 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_56 0957-0365 83.25 µM 1.28094665844837 0.0645460261265659 no 256 0.10010620133925 126 6752360 SGTC_1263 0774-1208 64.8 µM 1.28086950545954 0.0645576486067113 no 257 0.100119752727939 155 906585 SGTC_1040 k898-0338 155 µM 1.28007850808505 0.064676899819843 no 258 0.100258763203077 125 20969351 SGTC_2644 guaiazulene 100 µM 1.27880735504446 0.0648688978559797 no 259 0.100482451617315 103 3515 A coloring agent. SGTC_2877 9040724 71.43 µM 1.27617387172279 0.065268073268936 no 260 0.100947031361756 113 6463895 SGTC_1689 st020265 53.493 µM 1.27592406874199 0.0653060363885592 no 261 0.100991180946065 127 5758320 YPR016C TIF6 SGTC_1434 4073-0095 163 µM 1.27420570267159 0.0655676447128047 no 262 0.101295262359117 137 24133745 SGTC_3216 9129716 49.47 µM 1.27152858640455 0.0659768338047439 no 263 0.101770332160062 120 8056934 SGTC_2595 hexamethylquercetagetin 100 µM 1.26750827346959 0.0665950398059745 no 264 0.102486803595631 146 386331 SGTC_2820 7989630 71.43 µM 1.26691551034715 0.0666865673918805 no 265 0.102592751059684 87 2984098 SGTC_1724 st037281 8.293 µM 1.26521669279438 0.0669494183661009 no 266 0.102896830074064 132 574124 YDL195W SEC31 SGTC_111 0083-0039 52.457 µM 1.26383092999285 0.067164424588326 no 267 0.10314535851916 105 759313 SGTC_589 1227-0070 34.1 µM 1.26330621229985 0.0672459756943734 no 268 0.103239577258856 125 2841384 SGTC_983 1491-0821 12.2 µM 1.26184728089403 0.0674731237231339 no 269 0.103501872575528 119 46495113 SGTC_114 0364-0001 490.298 µM 1.25796796868147 0.0680799971061897 no 270 0.104201670333209 146 4003655 SGTC_3014 9081533 49.47 µM 1.25491954422202 0.0685598375906465 no 271 0.104753984153498 161 21367265 SGTC_1820 st053765 18.6 µM 1.254697112724 0.068594951516057 no 272 0.104794367144338 133 3690829 SGTC_1492 4158-0558 28.5 µM 1.25204884072168 0.0690140847403254 no 273 0.105276033832227 114 3967268 SGTC_822 1487-0950 154 µM 1.25129051621919 0.0691344650392721 no 274 0.105414252141432 117 1958375 SGTC_411 enrofloxacin 100 µM 1.25102715340806 0.0691763104281766 no 275 0.105462285457025 118 71188 A bacterial gyrase inhibitor. SGTC_2031 5180455 200 µM 1.24881053433259 0.0695292800042179 no 276 0.105867190022614 136 29949 SGTC_2143 5623677 140.463 µM 1.24866763950318 0.0695520817603593 no 277 0.105893330780855 127 5375313 SGTC_503 tyrphostin 8 294 µM 1.24649017924734 0.0699002522969732 no 278 0.106292246221224 143 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2015 5119600 184 µM 1.24261244135815 0.0705236120714315 no 279 0.107005341521931 152 2828786 SGTC_1501 4491-0275 38.4 µM 1.24215887150162 0.0705968032626455 no 280 0.107088975486151 132 5104718 SGTC_1117 retinoic acid 1.10837 µM 1.24153996101618 0.070696769135957 no 281 0.107203172727403 119 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1148 3909-7663 27.7 µM 1.23762109539629 0.0713322676044122 no 282 0.107928294335001 118 4084526 SGTC_426 0988-0037 14.6 µM 1.2365209110218 0.0715114637630068 no 283 0.108132498891211 155 5383008 SGTC_2829 7992743 58.44 µM 1.2348774199079 0.0717797959774864 no 284 0.108438064128536 123 16462845 SGTC_1154 4088-0362 150 µM 1.23278119566807 0.0721231656219802 no 285 0.10882870443584 142 6618304 SGTC_2717 st081029 62.2815 µM 1.2319227447696 0.0722641460525634 no 286 0.108988972093448 127 5292846 SGTC_1703 st026983 48.3 µM 1.23154954322424 0.0723255014787214 no 287 0.109058699476818 124 1104023 SGTC_686 1319-0111 510 µM 1.23069830997699 0.0724655960676934 no 288 0.109217860210957 143 4562600 SGTC_942 3253-1115 227 µM 1.23068208804353 0.0724682678643969 no 289 0.109220894953307 148 46497897 SGTC_2863 9028737 58.44 µM 1.22902546636847 0.0727415155395591 no 290 0.109531129012082 118 6460917 SGTC_1948 st076329 66.6 µM 1.22871007724303 0.0727936259570965 no 291 0.109590263284619 126 24208413 SGTC_953 1188-0045 9.7 µM 1.22361687026641 0.0736391179539525 no 292 0.110548396231976 138 6144426 SGTC_2077 5212015 200 µM 1.2231577753617 0.0737156968299274 no 293 0.110635055169253 127 780900 SGTC_1706 st031321 9.9705 µM 1.21614913155247 0.0748923381926182 no 294 0.111964058662996 138 6103185 SGTC_1167 k781-0610 148 µM 1.21230212600109 0.0755442518688772 no 295 0.112698375186285 152 4525169 SGTC_2371 9071574 200 µM 1.20923339690572 0.0760673720111495 no 296 0.113286595254152 140 45596039 SGTC_937 3122-0005 46.7 µM 1.20670983908992 0.07649962051014 no 297 0.113771954286607 140 759535 SGTC_1450 4112-4260 37.6 µM 1.20563093118343 0.076684990809559 no 298 0.113979913630945 152 1633175 SGTC_1092 toremifene 6.32 µM 1.20323224883328 0.0770983390681878 no 299 0.114443229336946 148 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1248 0469-0687 58.6 µM 1.20306329071013 0.0771275181543876 no 300 0.114475914788802 140 4017482 SGTC_1807 st050092 58.9 µM 1.2030554624103 0.077128870306 no 301 0.114477429357766 150 5008496 SGTC_2946 9065502 71.43 µM 1.20089627228383 0.0775025068565354 no 302 0.11489572022672 97 16489101 SGTC_956 1185-0240 191 µM 1.20029330712423 0.0776070919388564 no 303 0.115012724091383 135 1416193 SGTC_2359 9039622 200 µM 1.19943135438986 0.0777567847781492 no 304 0.115180130946991 139 6463596 SGTC_1224 0823-0416 294 µM 1.19431620859786 0.0786496301615564 no 305 0.116177149815145 139 3598164 SGTC_846 0335-0850 148 µM 1.19278680251856 0.0789180901777232 no 306 0.116476440013429 142 6819598 SGTC_2167 5876490 200 µM 1.19267394836337 0.0789379271828247 no 307 0.116498546142771 139 686534 SGTC_905 2-aminofluorene 215 µM 1.19136917682506 0.0791675485116622 no 308 0.116754343877074 131 1539 An established DNA mutagen. YPR165W RHO1 SGTC_3269 9137823 49.47 µM 1.19131139446849 0.0791777290713184 no 309 0.116765681187657 114 17682936 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.19038334499276 0.0793413761249522 no 310 0.116947878056341 158 279621 SGTC_979 1426-2828 121 µM 1.18980041003918 0.0794442984523687 no 311 0.117062424199914 149 747872 SGTC_853 0419-0306 21 µM 1.1887696487339 0.0796265357405419 no 312 0.117265162297039 175 762713 SGTC_334 1502-1024 68.5 µM 1.1883911352044 0.0796935357890095 no 313 0.117339673658193 122 3296216 SGTC_1088 bifonazole 369 nM 1.18091662871167 0.0810253373326307 no 314 0.118817922381239 136 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_326 k292-0812 17.5 µM 1.17854676916342 0.0814510851645682 no 315 0.119289349297658 133 3579357 SGTC_3003 9075612 71.4286 µM 1.17647148912902 0.0818252952158322 no 316 0.119703259497393 163 6501993 SGTC_2709 st078560 56 µM 1.17616600561937 0.0818804885814727 no 317 0.119764272949699 165 17250903 SGTC_2763 lisinopril 49.32 µM 1.17199904496162 0.0826361600111132 no 318 0.120598719793248 141 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1976 st070609 63.5 µM 1.1702287267716 0.0829587883674207 no 319 0.120954467654943 151 682556 SGTC_120 rhodamine 6G 52.259 µM 1.16623615074056 0.0836898847381302 no 320 0.121759490066089 197 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_920 mycophenolic acid 780.421 nM 1.16554163223294 0.0838175534915816 no 321 0.121899909209455 129 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2063 5246145 200 µM 1.16432134199448 0.08404222561559 no 322 0.122146905375376 160 711240 SGTC_3018 9082602 49.47 µM 1.16265554663934 0.0843496508233421 no 323 0.122484642145953 156 17332089 SGTC_601 0986-0029 62.9 µM 1.16139444852833 0.0845829491863379 no 324 0.122740762784952 151 24747981 SGTC_1664 st014217 9.02 µM 1.15971666514875 0.0848940826276105 no 325 0.123082091399243 156 3982782 SGTC_671 0560-0003 407 µM 1.15908051952708 0.0850122755476238 no 326 0.123211682799626 130 3238678 SGTC_27 0485-0001 32.618 µM 1.15814371122198 0.085186554700662 no 327 0.123402697261159 149 2054479 SGTC_3300 9124615 50.48 µM 1.15718745817747 0.0853647272231565 no 328 0.12359789034568 144 24824903 SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.15341820808722 0.0860697467671113 no 329 0.124369385732602 119 77254 SGTC_1476 4112-3294 3.34 µM 1.15234703306182 0.0862708974795751 no 330 0.124589248549789 157 704369 SGTC_282 k297-0036 65.7 µM 1.15209797370078 0.0863177174552284 no 331 0.124640407854433 151 5061378 SGTC_3226 9131256 49.47 µM 1.15031445933216 0.0866535507498318 no 332 0.125007188764542 137 17178073 SGTC_1946 st076057 65.1 µM 1.14672711865599 0.0873319980550167 no 333 0.125747209409781 135 953009 SGTC_149 3970-0822 46.1 µM 1.14448441358208 0.0877581541460221 no 334 0.126211399100611 164 3114250 YBL034C STU1 SGTC_20 0481-0013 4.944 µM 1.14326618302025 0.0879902900510704 no 335 0.126464045495544 175 182045 SGTC_2130 NSC 7 2.4545 µM 1.14258564890633 0.0881201661554418 no 336 0.126605333388041 154 21448 SGTC_2185 6113692 200 µM 1.135293854778 0.0895207444495031 no 337 0.128126108078648 155 874150 SGTC_2377 9073351 62.6 µM 1.13206287016482 0.0901466053135829 no 338 0.128804001770969 169 7337946 YHR072W ERG7 SGTC_813 k007-0158 173 µM 1.13037779919223 0.0904743004593491 no 339 0.129158532398697 156 6523916 SGTC_1049 3226-0134 66 µM 1.12976311102067 0.0905940585437019 no 340 0.129288028005403 142 5702385 SGTC_1829 berberine 14.4 µM 1.12930242174213 0.0906838905414802 no 341 0.129385139828857 173 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2398 5228213 48.84 µM 1.12638073464609 0.0912551438931529 no 342 0.130002198895813 183 80771 YMR134W ERG29 SGTC_2312 7706453 155.7 µM 1.12414669335455 0.0916937444185671 no 343 0.130475399671729 163 976098 SGTC_1736 st036774 51 µM 1.12363017563798 0.0917953722362644 no 344 0.130584974584725 174 1272247 SGTC_1293 1000-1278 195 µM 1.12346922598103 0.0918270570469482 no 345 0.130619131707188 167 678847 SGTC_2937 9044753 11.33 µM 1.12267053036445 0.0919844094126868 no 346 0.130788724192798 141 6465530 YGL099W LSG1 SGTC_2447 5741742 33.78 µM 1.1159816366378 0.0933100447849516 no 347 0.132214997545937 165 1776504 SGTC_2697 mebhydrolin 72.4 µM 1.11462966601543 0.0935796907367989 no 348 0.132504576117566 138 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1924 st058459 75.1 µM 1.11045175095884 0.0944165978725997 no 349 0.13340220421442 141 688683 SGTC_587 k089-0003 57 µM 1.10971601583692 0.0945645478425786 no 350 0.133560709592397 141 9659696 SGTC_3302 9125395 16.351 µM 1.10790716211561 0.0949290191810842 no 351 0.133950956075969 146 17599668 SGTC_1261 0712-0010 12.7 µM 1.10420904042445 0.0956773836139926 no 352 0.134751234463125 165 2840123 SGTC_1015 4130-4525 82 µM 1.10409566700247 0.095700394625909 no 353 0.13477582034195 172 1363237 SGTC_1627 st003713 25.6 µM 1.10388834216928 0.0957424851620897 no 354 0.13482078825085 158 16195070 YER133W GLC7 SGTC_641 4092-0595 30 µM 1.10326886238356 0.0958683314397923 no 355 0.134955212209387 165 786260 SGTC_1691 st019933 84.6 µM 1.10133205572311 0.0962625752514403 no 356 0.135376082292093 177 6176082 SGTC_1938 st074717 56.4 µM 1.10031698856804 0.0964696710602321 no 357 0.135597016336089 160 17250979 SGTC_1456 k015-0012 13 µM 1.09480854620829 0.0975992238730279 no 358 0.136800260767477 191 2989616 SGTC_183 3914-0051 30.55 µM 1.09292752294146 0.0979871564623849 no 359 0.137212811446249 134 1596232 SGTC_490 phenamil 164 µM 1.09218431458823 0.0981407429603977 no 360 0.137376047719505 167 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_383 2324-0395 7.37 µM 1.09165272248306 0.0982507063895346 no 361 0.137492886485872 149 3146421 SGTC_2048 5246248 200 µM 1.08716020974379 0.099183619057071 no 362 0.138483006194883 152 677046 SGTC_2685 mycophenolic acid 18.85 µM 1.08608598369957 0.0994076487898211 no 363 0.138720476437345 150 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1403 3909-7815 62.9 µM 1.08533386284388 0.0995647235277924 no 364 0.138886906549693 157 6615483 SGTC_2948 9070189 9.45 µM 1.08337187467917 0.0999753234234247 no 365 0.139321697147508 140 6473636 YDL196W YDL196W SGTC_2894 9048625 32.47 µM 1.08215025550603 0.100231604656766 no 366 0.139592884023994 176 4092861 SGTC_1837 st055472 66.5 µM 1.08209136353836 0.100243971599054 no 367 0.139605966497742 155 676091 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.07991062174238 0.1007026981632 no 368 0.140090991431022 166 165521 SGTC_726 3448-4391 34.2 µM 1.07915148943861 0.100862742960532 no 369 0.140260100501848 169 1356692 SGTC_229 benomyl 22.8748 µM 1.07683560156115 0.101352138013362 no 370 0.140776858608557 153 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_3319 9138450 16.7555 µM 1.07603616363039 0.101521476801397 no 371 0.140955541603983 149 2029690 SGTC_2847 9005661 71.43 µM 1.07360243415457 0.102038263315548 no 372 0.141500453087536 118 2991449 SGTC_2252 omeprazole 400 µM 1.07185290447973 0.102410945296703 no 373 0.141893053147006 138 4594 A proton pump inhibitor. SGTC_2751 anetholtrithion 17.25 µM 1.06952934295474 0.10290743546343 no 374 0.142415607072993 150 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2076 5212012 200 µM 1.06852280020217 0.103123051849625 no 375 0.142642375606848 152 604802 SGTC_39 0986-0283 58.349 µM 1.06799973336706 0.103235229990781 no 376 0.142760316034791 150 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_214 4373-3496 70 µM 1.06636228949859 0.103586972846375 no 377 0.143129950843541 195 3779166 SGTC_1359 1582-0056 520 nM 1.06588048134751 0.103690636502677 no 378 0.14323883669203 163 3661189 SGTC_2902 5787006 60.46 µM 1.06403952094765 0.104087422403771 no 379 0.143655398252358 165 591003 SGTC_692 k241-0027 77.8 µM 1.05977483565365 0.105010824936328 no 380 0.144623523827284 162 3600480 SGTC_534 k292-0788 63.4 µM 1.05767979403353 0.10546661551733 no 381 0.145100725131782 215 4146317 SGTC_2208 7283366 200 µM 1.05530516885454 0.105984959444277 no 382 0.145642888946558 177 898663 SGTC_1688 st021091 57.6 µM 1.05412441549629 0.106243383804419 no 383 0.145912979633414 175 3656366 SGTC_1720 st037298 9.481 µM 1.05221584938978 0.106662062011871 no 384 0.146350264708855 178 597396 SGTC_912 3474-0017 2.18 µM 1.0493011381522 0.107303752033901 no 385 0.147019771179879 167 3360550 SGTC_3025 9087895 49.47 µM 1.04925760030375 0.107313358186409 no 386 0.147029787327056 176 17173641 SGTC_511 blebbistatin 171 µM 1.04900464094708 0.107369183181426 no 387 0.147087991220094 163 3476986 A myosin inhibitor. SGTC_2103 5378138 10 µM 1.04735578537979 0.107733578163216 no 388 0.147467758000678 170 244142 SGTC_2642 cholecalciferol 100 µM 1.04644160209971 0.107935994999481 no 389 0.147678596853138 147 9821465 A vitamin D precursor, similar to steriods. SGTC_3081 9117243 49.47 µM 1.04325746824643 0.108643158192978 no 390 0.14841453186475 204 45595589 SGTC_1801 st050089 28.441 µM 1.04278919532784 0.108747437187329 no 391 0.148522968274683 179 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2346 9031566 143.75 µM 1.04141200970143 0.10905453765191 no 392 0.148842185534205 162 4771086 SGTC_1236 0330-0013 258 µM 1.04073865344416 0.109204916937516 no 393 0.148998429253604 155 4617066 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.03891721287804 0.109612442039101 no 394 0.149421620162951 212 16725076 SGTC_1700 st030840 7.9285 µM 1.03477621908201 0.110542999296312 no 395 0.150386715652711 196 5499307 SGTC_90 0870-0863 4.608 µM 1.03246201359486 0.111065503753439 no 396 0.150927866975284 195 1738164 SGTC_2347 9049783 174.81 µM 1.03167421047838 0.111243777912544 no 397 0.151112381351625 193 6467988 YPL169C MEX67 SGTC_795 0685-0265 78 µM 1.03097841557895 0.111401401570418 no 398 0.151275470898662 192 302754 SGTC_1673 st016611 27.3 µM 1.03063352599909 0.111479591232061 no 399 0.151356354030808 199 5226799 SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.03054314654252 0.111500087584669 no 400 0.151377554478494 143 6708630 An antioxidant. SGTC_156 3474-0145 5.642 µM 1.02962835456019 0.111707696913605 no 401 0.151592249784131 167 2265471 SGTC_542 3381-0244 89.3 µM 1.02783906219922 0.112114570595786 no 402 0.15201276911302 189 1112843 SGTC_73 0327-0325 16.231 µM 1.02705977145081 0.112292107113334 no 403 0.152196159936907 136 53298 SGTC_1280 0880-0253 10.1 µM 1.02661910807014 0.11239258707185 no 404 0.152299926430884 191 6836607 SGTC_3194 9111903 49.47 µM 1.02320219316549 0.113173891879775 no 405 0.153106128098152 177 17087251 SGTC_1041 0206-0046 107 µM 1.02153674003368 0.113556112565051 no 406 0.153500105804779 176 50494 SGTC_431 k089-0097 107 µM 1.02057907854018 0.113776311747788 no 407 0.153726952901958 196 5499420 SGTC_1002 4049-0206 172 µM 1.01927317999183 0.114077072757647 no 408 0.154036646507867 180 4662749 SGTC_992 3909-8734 162 µM 1.01448579173785 0.115184496965474 no 409 0.155175502870213 166 4288319 SGTC_283 0987-0079 11.7 µM 1.01353047459781 0.11540639371828 no 410 0.155403423759053 168 411556 SGTC_1247 0448-0043 5.84 µM 1.01308426926767 0.115510140295796 no 411 0.155509955691945 173 3089013 YGL099W LSG1 SGTC_2138 5575593 77.673 µM 1.01275177069239 0.115587492151511 no 412 0.155589371352461 165 762213 SGTC_797 k781-0471 270 µM 1.01171948551713 0.115827875526431 no 413 0.155836098047198 200 23738129 SGTC_1499 4480-0877 67.3 µM 1.00977641458532 0.116281311841857 no 414 0.156301211200294 165 2861909 SGTC_2563 tomatine 8.54 µM 1.00965313259747 0.116310123440287 no 415 0.156330752043474 177 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.00904355304028 0.116452659579708 no 416 0.156476873606324 169 4330530 SGTC_2096 5468907 200 µM 1.00493446859122 0.1174167074275 no 417 0.157464202849579 170 759785 SGTC_3187 9109394 49.47 µM 1.00267464962937 0.117949294330183 no 418 0.158008932520884 200 17098090 SGTC_81 0411-0046 9.971 µM 1.0022803987567 0.118042384923991 no 419 0.158104093341879 199 12925265 SGTC_489 paxilline 115 µM 1.00207375698686 0.118091197971649 no 420 0.15815398574418 177 105008 A toxic potassium channel blocker. SGTC_189 3970-0742 2.116 µM 1.00202703646169 0.118102236301729 no 421 0.158165267563804 180 2891807 SGTC_2625 euphol 100 µM 1.00177085753396 0.118162774866864 no 422 0.158227137653149 199 6708538 A triterpene alcohol. SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.999383546811271 0.118727984128062 no 423 0.158804463532359 211 5393153 SGTC_3034 9090421 49.47 µM 0.996411773628202 0.119434233233019 no 424 0.159525057394156 165 17173761 SGTC_2215 7188065 200 µM 0.994933143043474 0.119786735560179 no 425 0.159884391028933 187 940217 SGTC_1266 0828-0227 32.9 µM 0.994631240878456 0.119858798472914 no 426 0.159957823679699 188 3913820 SGTC_408 cantharidin 100 µM 0.993878225330693 0.12003867363269 no 427 0.160141078217749 168 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2594 a-mangostin 100 µM 0.992777471231522 0.120301956374165 no 428 0.160409205587439 193 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2444 5485484 36.41 µM 0.989079382533702 0.121189458103064 no 429 0.161312152065048 205 6790631 SGTC_1696 st025591 34.7925 µM 0.988806749406342 0.121255068924288 no 430 0.161378850688076 168 2787147 SGTC_2187 6125751 200 µM 0.988376275187826 0.121358716018442 no 431 0.161484201127602 198 874498 SGTC_2859 9028643 45.46 µM 0.988320116263804 0.121372242231715 no 432 0.161497948270169 155 17151580 SGTC_1866 st057638 64 µM 0.988098913224635 0.121425530619135 no 433 0.161552103982201 154 688802 SGTC_3237 9133362 49.47 µM 0.986567796540381 0.121794831585683 no 434 0.161927281950177 188 43845137 SGTC_669 0108-0021 26.2 µM 0.983013052132139 0.122655266567376 no 435 0.162800507430115 205 17201 SGTC_1217 1183-1422 255 µM 0.982827223264256 0.122700363909144 no 436 0.162846240499413 185 2849664 SGTC_1828 st055811 49 µM 0.981348515085777 0.123059634445819 no 437 0.163210452932721 176 5877589 SGTC_35 0133-0054 64.071 µM 0.980392598712257 0.123292278273495 no 438 0.16344618088004 199 99677 SGTC_2968 9090663 33.37 µM 0.980037749206819 0.123378717292194 no 439 0.163533742637523 227 25236811 SGTC_2003 4023581 200 µM 0.977415363612635 0.124018829568339 no 440 0.164181779987294 162 16641307 SGTC_1832 st054113 55 µM 0.977334890325677 0.124038509411738 no 441 0.164201692646843 165 1251267 SGTC_2474 5321570 43.32 µM 0.977230644245843 0.12406400617021 no 442 0.164227490078005 187 2841384 SGTC_687 k029-0044 34.9 µM 0.977187780046154 0.124074491063768 no 443 0.164238098301652 150 5829338 SGTC_1805 st050013 60.3 µM 0.974454646693648 0.124744315752512 no 444 0.164915423771093 187 4037144 SGTC_590 k048-0076 22.4 µM 0.973220035982936 0.125047716005739 no 445 0.165221977446952 196 6832814 SGTC_972 1319-0219 195 µM 0.972769977040249 0.125158444131694 no 446 0.16533381868888 206 23903702 SGTC_2480 5767542 37.17 µM 0.970162890509023 0.125801213412823 no 447 0.16598265245159 188 2867358 SGTC_3165 9101544 49.47 µM 0.965817416915712 0.126877687094478 no 448 0.167067775835565 195 5002184 SGTC_48 0382-0018 55 µM 0.964403502043567 0.127229324968923 no 449 0.167421833573963 170 762596 SGTC_2787 5284540 71.43 µM 0.963845720346466 0.12736823050782 no 450 0.16756164030761 204 736958 SGTC_22 0964-0034 14.468 µM 0.963613937942996 0.127425982774046 no 451 0.16761975816021 222 138402 SGTC_2825 7998094 58.44 µM 0.963196486721389 0.127530043305926 no 452 0.167724463945025 175 2987815 SGTC_1500 4488-1866 171 µM 0.962070639507681 0.127810984409541 no 453 0.168007060670932 200 2900003 SGTC_2828 7998861 71.43 µM 0.959163375577638 0.128538444201659 no 454 0.168738223811716 150 2988188 SGTC_3225 9130819 49.47 µM 0.95653190773323 0.129199367221707 no 455 0.169401785932905 203 4547121 SGTC_1038 k292-0204 154 µM 0.954468934089025 0.129719151133518 no 456 0.169923163596714 187 4454212 SGTC_1404 3909-7820 48.3 µM 0.953443994856326 0.129977931147163 no 457 0.170182579764988 184 23741373 SGTC_2504 purpurogallin 52.29 µM 0.953081442992639 0.130069554932554 no 458 0.170274403801312 179 5281571 An antioxidant. SGTC_2639 lactacystin 53 µM 0.94664240140986 0.131704273445808 no 459 0.171910514939534 190 3870 A proteasome inhibitor. SGTC_569 4130-2812 160 µM 0.946244224668525 0.131805824377984 no 460 0.172012017088885 183 743552 SGTC_376 3970-0862 59.1 µM 0.942182111882527 0.132844911923942 no 461 0.173049705302672 223 3135186 SGTC_2284 7945075 39.21 µM 0.941851608164854 0.13292970215624 no 462 0.173134309298023 215 1245402 SGTC_504 lovastatin 124 µM 0.941472735279415 0.133026947255385 no 463 0.173231327479368 196 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2391 6285546 200 µM 0.938778886037898 0.133719787962412 no 464 0.17392214074979 185 846083 SGTC_329 k048-0121 21.3 µM 0.936901450506118 0.134204116787778 no 465 0.174404626508286 193 6832902 SGTC_1370 2001-0092 44.6 µM 0.936570211928396 0.134289692489775 no 466 0.174489840304818 207 790957 SGTC_1232 0279-0259 161 µM 0.936443380685682 0.134322469343424 no 467 0.174522475665442 204 1560000 SGTC_3149 9097855 49.47 µM 0.934087515322764 0.134932291815368 no 468 0.175129375709464 183 25236625 YMR079W SEC14 SGTC_2373 9071805 200 µM 0.931948994113692 0.135487496146815 no 469 0.175681442897129 208 10149009 SGTC_1077 5-fluorocytosine 377 nM 0.930817982548705 0.135781762165959 no 470 0.175973863024359 223 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1790 st045711 43.5 µM 0.927978037567935 0.136522585986581 no 471 0.176709481087781 161 585119 SGTC_1927 st060202 13.8 µM 0.92752003675984 0.136642317763017 no 472 0.176828296754872 206 688887 SGTC_810 3825-7150 143 µM 0.925858133842357 0.137077379644167 no 473 0.177259855516337 168 22330411 YGL099W LSG1 SGTC_1860 st056228 74.6 µM 0.924966739129573 0.137311123283929 no 474 0.177491604472983 218 688679 SGTC_2179 6298986 200 µM 0.923902772050544 0.137590475420802 no 475 0.177768469848734 197 738374 SGTC_2401 5128683 200 µM 0.921702304791836 0.138169453875777 no 476 0.178341939021033 199 708373 SGTC_3100 9120536 49.47 µM 0.921360127865377 0.138259635174157 no 477 0.178431219200327 186 16421196 SGTC_1178 0988-0033 191 µM 0.920146477664142 0.138579818216235 no 478 0.178748109586111 200 5392207 SGTC_1323 1348-1351 11.2 µM 0.918946273391099 0.138896950434185 no 479 0.17906183738831 202 6989654 SGTC_1784 st039334 36.3 µM 0.916620661243899 0.139512856830312 no 480 0.179670726858506 227 3496984 SGTC_2906 7926292 26.41 µM 0.915147849664844 0.139903869991446 no 481 0.180057008969245 192 2966319 SGTC_1256 0570-0116 285 µM 0.913043623848709 0.140463806898678 no 482 0.180609799323625 202 410638 SGTC_3049 9092223 49.47 µM 0.911657062469952 0.140833602982557 no 483 0.180974636810123 185 8623917 SGTC_2370 9071495 200 µM 0.910864938818398 0.141045158650652 no 484 0.181183270630987 211 21791103 SGTC_1511 0906-3109 28.5 µM 0.910631564958164 0.141107527832575 no 485 0.181244766622575 197 2882180 SGTC_3132 9126706 49.47 µM 0.910630789976034 0.141107734977758 no 486 0.181244970858714 219 850858 SGTC_235 0330-0087 5 mM 0.906180738510199 0.142300591400057 no 487 0.182420098141819 196 46494818 YHR062C RPP1 SGTC_3197 9113331 49.47 µM 0.906161859938128 0.142305666376973 no 488 0.182425093533288 185 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2523 spermine 47.74 µM 0.90434485149151 0.142794691491624 no 489 0.18290628552421 185 1103 A DNA binding polyamine. SGTC_2384 9036245 200 µM 0.904263003884053 0.142816746457424 no 490 0.182927979567986 183 6462766 SGTC_650 1328-0195 38 µM 0.903476843129045 0.143028705579098 no 491 0.183136436474648 215 2780821 SGTC_865 0488-0499 301 µM 0.903340995005829 0.143065353518911 no 492 0.183172472716486 195 9634651 SGTC_2012 4023501 200 µM 0.902929424675144 0.143176422151037 no 493 0.183281676398448 228 3477460 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.901497310026495 0.143563354340817 no 494 0.183661981708262 200 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1590 st077108 57.8 µM 0.899801964381763 0.144022318469105 no 495 0.184112824399573 183 5489485 SGTC_1737 st035557 69.7 µM 0.899617944759057 0.144072195745514 no 496 0.184161802088305 208 5716916 SGTC_2201 6605497 169.863 µM 0.898129906121782 0.14447594646901 no 497 0.184558148443426 211 670741 SGTC_182 3448-4371 550.524 µM 0.895723081614619 0.145130604578748 no 498 0.185200339835439 184 3491403 SGTC_1432 4049-0298 68.4 µM 0.894314696578075 0.145514610875919 no 499 0.185576769421458 205 741646 SGTC_2918 7977171 22.06 µM 0.894255514501612 0.145530762240182 no 500 0.185592597844892 212 2236483 SGTC_316 k060-0003 58.6 µM 0.893896333421397 0.145628812110871 no 501 0.185688679869518 218 6152314 SGTC_68 0986-0284 82.829 µM 0.89329890045069 0.145791998752898 no 502 0.185848563334804 207 423278 YIL048W NEO1 SGTC_3251 9135047 49.47 µM 0.891579601449456 0.146262304611946 no 503 0.186309153881238 183 17682963 SGTC_782 0083-0095 30.5 µM 0.88927668414099 0.146893851064441 no 504 0.186927199502442 191 3591729 An indicator and reagent. SGTC_976 1348-1067 47.6 µM 0.887587279285153 0.147358310746166 no 505 0.187381399370083 207 5310671 YGL099W LSG1 SGTC_723 4182-0001 115 µM 0.887339938466392 0.147426393429452 no 506 0.187447954648469 193 744821 YLR208W SEC13 SGTC_2426 5582046 32.21 µM 0.887114940659779 0.147488344311394 no 507 0.187508510484884 203 2251934 SGTC_2038 4100038 30.985 µM 0.885406436744013 0.147959332684677 no 508 0.187968731020578 215 3596803 SGTC_1825 st052143 62.6 µM 0.879134948434932 0.14969683556994 no 509 0.18966405525703 208 674173 SGTC_2831 7999036 19.48 µM 0.879116422367879 0.149701988261778 no 510 0.189669077161567 211 2988270 SGTC_487 nimodipine 119 µM 0.877628245754637 0.150116284310481 no 511 0.190072747829499 194 4497 L-type voltage-gated calcium channels inhibitor SGTC_425 3825-7017 13.1 µM 0.876206772441144 0.150512723758544 no 512 0.19045881773133 221 3397440 SGTC_127 0180-0333 59.125 µM 0.875763207476597 0.150636573709568 no 513 0.190579387778228 178 771601 SGTC_1714 st033236 13.627 µM 0.874677120993039 0.150940111711356 no 514 0.190874806108228 222 2916566 SGTC_118 0083-0097 135.343 µM 0.871305311371567 0.151885052711484 no 515 0.191793735585839 252 5207356 SGTC_280 3448-3607 3.04 µM 0.870473316128914 0.152118820476981 no 516 0.192020897736885 189 626179 SGTC_69 0096-0274 206.684 µM 0.869426758718207 0.152413213430813 no 517 0.192306876147898 267 6741392 SGTC_2393 9031399 185.94 µM 0.866631690458718 0.153201308738851 no 518 0.193071922043646 219 1526623 YDL150W RPC53 SGTC_2921 7974240 10.71 µM 0.86457476325561 0.153783000236278 no 519 0.193636114511651 216 2979074 YDR527W RBA50 SGTC_3096 9117468 49.47 µM 0.862570357683877 0.154351243458275 no 520 0.194186866977798 209 41316311 SGTC_255 tunicamycin 200.472 nM 0.86242752796819 0.154391788194923 no 521 0.194226148819727 215 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2318 6029776 164 µM 0.862335529677084 0.154417907262294 no 522 0.194251453276014 222 818325 SGTC_838 0109-0203 71.4 µM 0.862119670511873 0.154479202912761 no 523 0.194310833986315 208 759422 SGTC_2158 5657123 3.6195 µM 0.859570198847343 0.155204370886741 no 524 0.195013004184495 227 2858827 SGTC_1390 3413-2614 145 µM 0.859274198640949 0.155288710108404 no 525 0.195094627778272 244 3421432 SGTC_3073 9114972 49.47 µM 0.859132161760661 0.1553291913584 no 526 0.195133802557721 197 41905075 SGTC_2260 7964312 200 µM 0.858508281299514 0.155507083006292 no 527 0.195305929829852 230 231951 SGTC_2804 7954240 19.48 µM 0.858034266079971 0.155642332289705 no 528 0.195436771256272 213 828705 SGTC_3271 9137798 49.47 µM 0.855197103850337 0.156453472377341 no 529 0.196221019633868 190 6498326 SGTC_1958 st076513 41.9 µM 0.853305317921273 0.156995875063201 no 530 0.196745005891844 225 732122 YGL099W LSG1 SGTC_2057 5236571 38.335 µM 0.8522309146049 0.157304472296725 no 531 0.197042970720693 203 54684039 YBR257W POP4 SGTC_1540 guanosine 70.6 µM 0.851729299579705 0.157448685946705 no 532 0.197182177347882 211 6802 Guanosine is a purine nucleoside SGTC_1560 lithocholic acid 53.1 µM 0.851346502155299 0.157558798134546 no 533 0.197288450108035 210 9903 A bile acid which acts as a detergent. SGTC_1093 fluphenazine 7.97 µM 0.849253066345136 0.158161872551739 no 534 0.197870245297792 230 6602611 An atypical antipsychotic. SGTC_3202 9113761 49.47 µM 0.848311221884657 0.158433691425765 no 535 0.198132334794797 222 4798415 SGTC_766 1391-0721 126 µM 0.847258905677439 0.158737754988845 no 536 0.198425413333117 242 1020919 YIL115C NUP159 SGTC_3257 9139206 32.98 µM 0.846455690277433 0.15897009890495 no 537 0.198649291216491 220 4910041 SGTC_337 1315-0038 354 µM 0.846235730626591 0.159033764879478 no 538 0.198710626487421 217 1626437 SGTC_359 0081-0058 15.9 µM 0.846118837647178 0.159067605633901 no 539 0.198743226487111 224 3494159 SGTC_1417 3966-0327 90.4 µM 0.845959936095982 0.159113615519929 no 540 0.198787547326432 215 651118 SGTC_816 0325-0417 81.3 µM 0.845846236336311 0.159146542594068 no 541 0.198819264133698 226 68101 SGTC_1186 1319-0216 26 µM 0.844845382271328 0.159436579177642 no 542 0.199098586253106 222 4565136 SGTC_155 k072-0202 43.6 µM 0.844251562384709 0.159608825160761 no 543 0.199264423431462 234 5857737 SGTC_1100 amiodarone 5.07 µM 0.841859673750252 0.160303859538985 no 544 0.199933252528225 212 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2350 9023895 38.85 µM 0.841481195814476 0.160414018549538 no 545 0.200039207550085 223 2997209 SGTC_1693 xanthone 101.9 µM 0.840656797499836 0.160654137399454 no 546 0.200270114943217 261 7020 An insecticide. SGTC_2102 5377816 72.7585 µM 0.839928700212134 0.160866402187207 no 547 0.20047418231326 235 1379702 SGTC_2382 9035899 200 µM 0.839485421121606 0.160995722540088 no 548 0.200598483440028 241 6462679 SGTC_3075 9116269 49.47 µM 0.837840084626426 0.161476319144127 no 549 0.201060261333501 224 17015205 YNL244C SUI1 SGTC_495 decylubiquinone 155 µM 0.836331003983491 0.161917937537575 no 550 0.201484357922191 221 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1809 st050081 57.6 µM 0.834817947242979 0.162361508693626 no 551 0.201910109617271 249 5036894 SGTC_3032 9089427 49.47 µM 0.833824051853767 0.162653311339986 no 552 0.20219006987265 207 17173707 SGTC_3333 9141820 12.094 µM 0.833692978332689 0.1626918193081 no 553 0.202227007961293 217 1939433 SGTC_506 n9-isopropylolomoucine 153 µM 0.833489328279639 0.162751661231893 no 554 0.202284406994231 217 6610355 SGTC_58 0957-0393 9 µM 0.833096692028563 0.162867076555132 no 555 0.202395099535319 241 6997992 SGTC_804 1595-0054 20.9 µM 0.832754950430292 0.16296757471777 no 556 0.202491473264378 225 761523 Stimulates phospholipase C. SGTC_257 daunorubicin 18.5 µM 0.830291951381426 0.163693076847792 no 557 0.203186868783565 216 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_99 0109-0120 622.8 µM 0.827699898607439 0.164458853971219 no 558 0.203920238288965 238 759414 SGTC_1855 st056195 39.6 µM 0.826852089626927 0.164709827612017 no 559 0.204160450807089 209 4028379 SGTC_1377 2944-0135 198 µM 0.826149790830105 0.164917914237778 no 560 0.204359563011712 209 1894137 SGTC_135 0933-0004 26.348 µM 0.823848905680292 0.165600843720192 no 561 0.205012707654421 232 21230617 YGL099W LSG1 SGTC_1358 1509-0022 2.48 µM 0.823841615540845 0.165603010420875 no 562 0.205014779052199 251 3258434 SGTC_2435 5706476 10.6 µM 0.821604726301512 0.166268701568881 no 563 0.205650949252877 214 5725375 SGTC_529 4076-0302 30.3 µM 0.820255514293268 0.166671057204807 no 564 0.206035230352202 235 5816522 SGTC_2150 5556613 200 µM 0.820140362829914 0.166705426208247 no 565 0.20606804737839 239 743190 SGTC_635 k038-0028 24.7 µM 0.819319607915776 0.166950527570865 no 566 0.206302044163606 232 4035102 SGTC_1162 k048-0130 20.1 µM 0.819106188749859 0.167014298816681 no 567 0.206362915641807 228 6797406 SGTC_988 1497-1057 103 µM 0.818268197521577 0.167264848785782 no 568 0.206602030671045 238 3533044 SGTC_1084 voriconazole 435 nM 0.818127269435848 0.167307008486518 no 569 0.20664225964298 250 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1250 0485-0349 40.2 µM 0.81713670948073 0.167603535203293 no 570 0.206925153230928 223 6842794 YDL195W SEC31 SGTC_519 k048-0011 62.8 µM 0.816792822055572 0.167706557916042 no 571 0.207023417463621 221 6836379 SGTC_342 k048-0088 23.3 µM 0.814623112088087 0.168357505517822 no 572 0.207644038370396 244 6820570 SGTC_2443 5493264 126.67 µM 0.812865699341586 0.168885946880938 no 573 0.208147531174591 239 5340055 SGTC_3160 9100216 49.47 µM 0.812115898480811 0.169111730561123 no 574 0.208362565670637 228 17191039 SGTC_1039 k821-0043 94 µM 0.811735912088921 0.16922622788386 no 575 0.208471591526971 221 15992768 SGTC_287 k060-0039 29.6 µM 0.808611235113464 0.170169640765952 no 576 0.209369400127892 245 5861974 SGTC_1055 3448-0672 86 µM 0.807886197903629 0.170389027217873 no 577 0.209578048716534 216 748378 SGTC_859 0439-0102 54.6 µM 0.806528818225735 0.170800238758444 no 578 0.209968999184795 252 610143 SGTC_2708 st078559 56 µM 0.806323108819409 0.170862612789977 no 579 0.210028284673894 215 17250902 SGTC_45 0kpi-0036 14.9 µM 0.803513247850637 0.171716061704347 no 580 0.210839071363323 235 2795021 SGTC_31 0508-1974 57.237 µM 0.802679635791877 0.171969780475382 no 581 0.211079963109324 205 6810525 SGTC_2624 nerol 100 µM 0.802457719136229 0.172037363507277 no 582 0.211144118306991 257 637566 A natural product oil. SGTC_1562 morin hydrate 59.1 µM 0.801656843657914 0.172281405029079 no 583 0.21137574314683 230 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_3213 9129884 49.47 µM 0.801527976088228 0.172320693972886 no 584 0.211413027418111 223 17190742 SGTC_1058 3448-5425 97.3 µM 0.801275655251119 0.17239763770831 no 585 0.211486040634532 243 7279705 SGTC_1345 1488-0192 31.4 µM 0.801005751904942 0.172479967380352 no 586 0.211564157983498 225 658348 SGTC_2533 agelasine 13.65 µM 0.800754174517296 0.172556729589076 no 587 0.211636986512089 224 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2965 9082772 38.63 µM 0.797908670234987 0.173426476464798 no 588 0.212461745795903 178 16459634 SGTC_482 fipronil 114 µM 0.796886483706611 0.173739594491902 no 589 0.212758480732297 235 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_754 3474-0146 171 µM 0.794672801937919 0.174418925323195 no 590 0.213401928682935 238 24762078 SGTC_786 4544-0069 423 µM 0.793366204690578 0.174820682416906 no 591 0.21378224733917 242 748821 YLR208W SEC13 SGTC_1057 3448-5381 134 µM 0.792833235994794 0.174984730022899 no 592 0.213937494831704 230 5497911 SGTC_1605 st000082 49.1 µM 0.790217976020396 0.175791121171507 no 593 0.214700239822307 241 1114022 SGTC_3282 9108498 15.4605 µM 0.788630451500473 0.176281765906532 no 594 0.215164013796454 245 16459645 SGTC_2973 9094665 17.96 µM 0.78744285426153 0.176649374050168 no 595 0.215511334294571 253 25237061 YIL048W NEO1 SGTC_1196 1588-0294 184 µM 0.785515961136053 0.177246853845306 no 596 0.216075557926647 236 6144269 SGTC_1138 3761-0006 1.03 µM 0.784534594606 0.177551640194281 no 597 0.216363245514437 225 12061087 SGTC_839 0122-0028 230 µM 0.783788608608306 0.17778354475818 no 598 0.216582079542405 265 759448 SGTC_756 0508-1999 28.3 µM 0.780952568217573 0.178666927211828 no 599 0.217415196133515 264 6753853 SGTC_2193 5925765 200 µM 0.780245347535152 0.178887645270034 no 600 0.217623237481542 238 877370 SGTC_544 k015-0020 52.4 µM 0.779360613356982 0.179164005421073 no 601 0.217883659209121 246 3008304 SGTC_2566 crystal violet carbinol 226 nM 0.778363492071542 0.179475793097779 no 602 0.218177377412233 273 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1524 corynanthine 62.1 µM 0.778346393399431 0.179481142617002 no 603 0.218182416091838 249 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2307 7538926 6.34 µM 0.777403328618774 0.179776346647581 no 604 0.218460424616949 259 96582 SGTC_70 0141-0289 43.283 µM 0.775355946465289 0.180418280194997 no 605 0.219064679429706 245 352408 SGTC_2884 9058502 51.95 µM 0.773566577714196 0.180980492632238 no 606 0.219593571546886 237 6471554 SGTC_1906 st060206 94.7 µM 0.772419826222053 0.181341373899859 no 607 0.219932907501859 255 5133468 SGTC_1191 1487-1166 10.6 µM 0.772183664566263 0.181415749592712 no 608 0.220002827592352 259 3955771 SGTC_610 4215-0184 155 µM 0.772147368209594 0.181427182297413 no 609 0.220013574940534 239 5605015 SGTC_2768 sulfasalazine 50.2 µM 0.770993995024747 0.181790709134743 no 610 0.220355245473255 264 5384001 An antioxidant and salicylic acid derivative. SGTC_372 0155-0182 15.9 µM 0.7704613928242 0.181958731459793 no 611 0.220513123961907 223 771486 SGTC_306 1672-3436 11.6 µM 0.770427423338147 0.181969451254262 no 612 0.22052319568523 255 6797378 SGTC_1775 st081588 35.1725 µM 0.770384838148342 0.181982890475312 no 613 0.22053582227891 250 1426443 YGL099W LSG1 SGTC_3168 9103419 49.47 µM 0.769815268218149 0.182162697511596 no 614 0.220704740716894 239 16649256 SGTC_1424 4048-1941 275 µM 0.769766409944148 0.182178126707409 no 615 0.220719234158421 247 X1424 SGTC_1856 st057054 55.7 µM 0.769054843495115 0.182402928362809 no 616 0.220930376795031 257 1266018 SGTC_2783 7738165 71.43 µM 0.767720526805347 0.182824939355005 no 617 0.221326619223084 258 17201110 SGTC_549 1661-1316 519 µM 0.766969986560985 0.183062584056488 no 618 0.221549680241385 257 2857282 SGTC_3107 9121808 49.47 µM 0.765708750322023 0.183462365008892 no 619 0.22192480966145 221 662681 SGTC_1793 st048256 72.231 µM 0.765404510112085 0.183558883106253 no 620 0.222015354079893 246 672022 SGTC_2235 salicylic acid 500 µM 0.764133231045974 0.183962529866852 no 621 0.222393925420451 246 338 A COX inhibitor and kinase inhibitor. SGTC_774 k060-0086 136 µM 0.76330010326887 0.18422735775732 no 622 0.22264222025901 235 5911235 SGTC_2852 9023854 51.95 µM 0.762557650788774 0.184463562345255 no 623 0.222863624481143 269 19798528 SGTC_1969 st069479 40.1 µM 0.76186509226338 0.184684063353005 no 624 0.223070263028446 255 3895485 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.760821883733542 0.185016515638211 no 625 0.223381730797307 241 4213774 SGTC_1643 st009866 20.2 µM 0.759774625024303 0.185350632372566 no 626 0.223694656567285 234 3156273 YOR207C RET1 SGTC_951 1171-0579 82.7 µM 0.759543019501753 0.185424574199724 no 627 0.223763895013767 266 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_150 3970-0969 77.2 µM 0.758988211904299 0.185601775205836 no 628 0.223929804222959 279 6615640 SGTC_2176 5809774 33.9695 µM 0.757394996870395 0.186111218924664 no 629 0.22440662631798 219 2870539 SGTC_521 r062-0005 13.8 µM 0.756926432115305 0.186261211175339 no 630 0.224546969342244 234 2832033 SGTC_1972 st070201 17.4 µM 0.752982454827457 0.18752668443786 no 631 0.225730228655021 239 2829099 SGTC_783 0848-0141 92.7 µM 0.750083118383041 0.188460352046656 no 632 0.226602323100619 271 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.749019276313138 0.188803656735903 no 633 0.226922793583733 259 5024745 SGTC_3042 9091578 49.47 µM 0.748836478262392 0.188862684933783 no 634 0.226977885168566 238 25236497 SGTC_2788 5282734 71.43 µM 0.747954148813962 0.189147762061411 no 635 0.227243907215996 256 743706 SGTC_3119 9125183 49.47 µM 0.747875286754999 0.189173254972457 no 636 0.227267692652728 216 22695334 SGTC_2765 myclobutanil 7.74 µM 0.747690834104169 0.189232889308022 no 637 0.227323330546341 273 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_468 gf-109203x 121 µM 0.745732352477087 0.189866788509492 no 638 0.227914555789122 223 2396 A protein kinase C inhibitor. SGTC_3131 9127911 49.47 µM 0.742527789459886 0.19090681716306 no 639 0.228883810571418 248 45595681 SGTC_1610 st001799 48.1 µM 0.742469909537049 0.190925633944828 no 640 0.228901338223706 251 621897 SGTC_3021 9087658 49.47 µM 0.742275811705297 0.190988743517635 no 641 0.228960121950026 243 25237042 SGTC_452 diindolylmethane 8 µM 0.739852927845302 0.19177760382297 no 642 0.229694619708472 242 3071 Inhibits expression of several cancer promoting factors. SGTC_1522 st012842 45.6 µM 0.735148624397367 0.193314952261403 no 643 0.231124491903035 259 3491067 YOR116C RPO31 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.733540177418665 0.19384230710056 no 644 0.23161451618774 255 140250 A respiratory chain inhibitor. SGTC_1876 myriocin 605 nM 0.732990655047368 0.194022677499202 no 645 0.231782064520053 281 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1882 5615643 20 µM 0.73252494221888 0.194175619016471 no 646 0.231924112326089 245 2253075 SGTC_2362 9071156 126 µM 0.732411428328657 0.194212908452572 no 647 0.231958742724238 264 653133 SGTC_2131 toluylene red 5.2905 µM 0.731274296691443 0.194586698060164 no 648 0.232305813497624 234 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1001 4048-4355 44.4 µM 0.730232278919502 0.194929606637662 no 649 0.232624107515352 264 21824233 SGTC_3125 9127534 49.47 µM 0.730148431357012 0.194957215267891 no 650 0.232649730067508 236 1639235 SGTC_3043 9092303 49.47 µM 0.729947930447108 0.195023244185029 no 651 0.232711006485935 244 25236084 SGTC_604 1000-0114 314 µM 0.72928858202116 0.195240476518066 no 652 0.232912577585862 264 1572745 SGTC_142 0335-0849 62.6745 µM 0.72499306961127 0.196659294221358 no 653 0.234228141053473 247 3889043 YPR107C YTH1 SGTC_360 0957-0399 1.01 µM 0.724558987518616 0.196803019185373 no 654 0.234361313514419 268 6752301 YPR165W RHO1 SGTC_2667 digitoxin 100 µM 0.723935948498917 0.197009419085423 no 655 0.234552529463037 231 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2505 galangin 7.89 µM 0.721880161086154 0.197691387647247 no 656 0.235184079755086 269 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_545 4218-0007 221 µM 0.721826733195864 0.197709130338722 no 657 0.235200505635531 271 2840508 SGTC_2458 5808907 16.39 µM 0.719791331367028 0.198385776656427 no 658 0.235826741506379 278 2731747 SGTC_1988 st071872 53.4 µM 0.719275474288298 0.198557489209879 no 659 0.235985602100399 248 16414116 SGTC_1556 plumbagin 1.48 µM 0.718967440702361 0.198660066612015 no 660 0.236080490594115 259 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3048 9093155 49.47 µM 0.718251770075925 0.198898513428392 no 661 0.236301031152488 244 25236002 SGTC_2913 7966556 36.57 µM 0.718063605201822 0.198961234744156 no 662 0.236359034736522 253 2976516 SGTC_1886 st057356 49.9 µM 0.718017370244554 0.198976648144707 no 663 0.236373288294505 251 24207747 SGTC_3326 9140064 16.379 µM 0.717422492203919 0.199175027500141 no 664 0.236556722659694 271 1868434 SGTC_2869 9037858 32.47 µM 0.716433180924963 0.199505205766894 no 665 0.23686195635849 261 27187042 SGTC_1626 st003712 1.76 µM 0.71589886285478 0.199683668996914 no 666 0.237026900334057 281 24207035 SGTC_2032 5185112 25.99 µM 0.715884579249815 0.199688441065336 no 667 0.23703131054871 240 5718189 SGTC_60 0986-0278 202 µM 0.715432975157695 0.199839354714179 no 668 0.237170771356433 285 3110598 SGTC_2399 5884133 200 µM 0.715172762506151 0.199926341756722 no 669 0.23725114863695 262 722445 SGTC_1548 st061468 90.8 µM 0.714878560671975 0.200024718535409 no 670 0.237342042879353 260 390799 SGTC_2025 5147754 141 µM 0.714233142358792 0.200240638884624 no 671 0.237541513124881 248 315777 YLR208W SEC13 SGTC_2846 9008642 19.48 µM 0.713930876643801 0.200341807981707 no 672 0.237634961709533 298 2992898 SGTC_228 caffeine 993.056 µM 0.713650230967124 0.200435768284221 no 673 0.237721744290761 230 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2520 obtusaquinone 4.71 µM 0.712793123729606 0.200722892001198 no 674 0.237986890634292 264 5967872 SGTC_2870 9038528 12.99 µM 0.712452959210313 0.200836912656459 no 675 0.238092165536556 264 6463316 SGTC_2585 alliin 100 µM 0.711463199221149 0.201168893963679 no 676 0.238398623860465 270 87310 A garlic compound which reacts with lipids. SGTC_274 sirtinol 40.1 µM 0.709494647208287 0.201830155074151 no 677 0.239008786027411 251 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2295 7971645 200 µM 0.708873285668045 0.202039148078581 no 678 0.239201557154 257 2978226 YKL099C UTP11 SGTC_1752 st044819 83.042 µM 0.708809811316381 0.202060504766221 no 679 0.239221254210528 263 441209 YML126C ERG13 SGTC_2739 tacrine 100.86 µM 0.708400233511155 0.202198344488379 no 680 0.239348373738658 248 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2255 7941087 197.44 µM 0.706427092911837 0.202863175082569 no 681 0.239961288641497 251 935561 SGTC_1483 3453-0561 55.9 µM 0.705797583653586 0.203075556573253 no 682 0.240157012484623 281 4546991 SGTC_1620 st003704 16.5 µM 0.705192849491668 0.203279704503671 no 683 0.240345115293392 267 2834414 SGTC_2998 9066762 71.4286 µM 0.704415699020152 0.203542236994014 no 684 0.240586966069977 268 4945196 SGTC_2707 st078556 66.6 µM 0.703569227223183 0.20382841717945 no 685 0.240850540459538 257 17250899 SGTC_3349 9149703 23.001 µM 0.703361110146676 0.203898815344342 no 686 0.240915368007331 259 4910494 SGTC_2328 6201408 200 µM 0.70301918649525 0.204014506685575 no 687 0.241021896314269 296 2890418 SGTC_964 1287-0107 19.4 µM 0.702981005731274 0.204027427738586 no 688 0.241033793343531 251 51516812 YPR165W RHO1 SGTC_4 0960-0234 25.671 µM 0.702756408502296 0.204103445324412 no 689 0.241103783734493 257 6821112 SGTC_57 miconazole 162.5 nM 0.701343842039705 0.20458193173532 no 690 0.241544229690721 258 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2020 4017018 200 µM 0.699138531056044 0.20533028186077 no 691 0.242232730378732 277 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1887 st057648 70.8 µM 0.698194212442346 0.205651223461554 no 692 0.242527872710921 281 688672 SGTC_967 1306-0166 352 µM 0.696408485929715 0.206258944126222 no 693 0.243086525099175 280 4437607 SGTC_2683 piperine 63.03 µM 0.695903969706365 0.206430834376693 no 694 0.243244485553264 278 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_453 enantio-paf c16 10 µM 0.694119445836472 0.207039507889328 no 695 0.24380365227592 294 13871343 A lipid and platelet activating factor SGTC_586 0957-0265 8.15 µM 0.69410303599284 0.20704510995603 no 696 0.243808797390482 270 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_611 3453-1652 23.7 µM 0.693276561619935 0.207327371505682 no 697 0.244068004552038 287 1560575 SGTC_3328 9140624 29.0385 µM 0.692529183833317 0.207582815400099 no 698 0.24430253256873 264 4904392 SGTC_3234 9132280 49.47 µM 0.691060154392842 0.208085452040038 no 699 0.244763869526974 264 17612295 SGTC_1330 1469-0054 61.8 µM 0.690089440892346 0.208417980906051 no 700 0.245068971494139 274 7102664 SGTC_535 2293-4129 48.2 µM 0.687887623547281 0.209173398949564 no 701 0.245761775490881 290 396118 YIL048W NEO1 SGTC_3242 9133940 49.47 µM 0.685387625475368 0.210033070572718 no 702 0.246549675315045 269 17248444 SGTC_725 1497-0963 19 µM 0.685387358881878 0.210033162356489 no 703 0.246549759406794 268 3549977 SGTC_2876 9059903 25.97 µM 0.685316001084617 0.21005773052457 no 704 0.246572268393168 261 6916095 SGTC_893 0958-0369 48.9 µM 0.684094793515175 0.2104784484295 no 705 0.246957654671811 278 6819948 SGTC_1298 1079-1278 263 µM 0.6829522994843 0.210872496185233 no 706 0.247318492315482 277 2840950 SGTC_2253 7938677 135.83 µM 0.682495280678126 0.211030243653723 no 707 0.24746291295032 259 2301972 SGTC_2107 5363541 170.161 µM 0.682179862229161 0.211139155791506 no 708 0.247562613316577 264 244052 SGTC_2871 9038510 12.99 µM 0.682068313091099 0.211177680937078 no 709 0.247597877930579 294 4945164 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.681315882014195 0.211437651724352 no 710 0.247835817991363 262 88881 An O-methylated flavonoid and antioxidant. SGTC_901 1112-0062 60.1 µM 0.68113756248842 0.211499289967777 no 711 0.247892225572805 272 1908457 SGTC_249 wiskostatin 11.211 µM 0.680922701305414 0.211573573239945 no 712 0.247960201430256 261 2775510 A n-wasp and actin depolymerizer. SGTC_1603 st002045 67.8 µM 0.679061835485301 0.212217563160087 no 713 0.24854934140278 281 5887985 SGTC_935 2996-0153 430 µM 0.678582551789353 0.212383614267625 no 714 0.248701200692345 281 23738523 SGTC_1583 clindamycin 39.6 µM 0.677232950352336 0.21285160057854 no 715 0.249129082309676 281 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2262 9014885 67.46 µM 0.676824419573326 0.212993380847326 no 716 0.249258681275065 275 6457424 SGTC_1750 st081859 2.357 µM 0.676773644005661 0.213011006315234 no 717 0.249274791405431 283 5291695 SGTC_3277 9138724 49.47 µM 0.675633517606056 0.213406996701433 no 718 0.249636677753942 257 15943418 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.675242918821528 0.213542758672865 no 719 0.249760721460613 292 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2808 7946468 45.46 µM 0.674500295963374 0.213801013807718 no 720 0.249996648814132 292 2970879 SGTC_2368 9071271 200 µM 0.673789516650202 0.214048365278009 no 721 0.250222570353992 288 27209959 SGTC_1970 st070122 35.8 µM 0.673562329425796 0.214127461630532 no 722 0.250294804747413 294 102928 SGTC_2288 7946289 167.31 µM 0.672167658636505 0.21461339569255 no 723 0.250738483799511 285 1246052 SGTC_1008 4106-0037 6 µM 0.6720712936094 0.214646995050648 no 724 0.250769155257591 297 2905394 SGTC_2740 felodipine 17.08 µM 0.671503823273038 0.214844915543909 no 725 0.250949812342328 249 3333 L-type calcium channel blocker SGTC_1656 st012921 11 µM 0.670573882511087 0.215169486431433 no 726 0.251246012597475 271 6732821 SGTC_763 3453-1109 128 µM 0.67038387861017 0.215235837199113 no 727 0.251306554462186 278 1560353 SGTC_2071 5230951 39.92 µM 0.669734140770445 0.215462820172148 no 728 0.25151364185194 293 1799272 SGTC_3063 1327-0034 4 µM 0.669036543586166 0.215706677089265 no 729 0.25173608352501 288 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1939 st074455 53.6 µM 0.668688961157877 0.215828240114037 no 730 0.251846955328886 289 1644229 SGTC_345 1362-0200 395 µM 0.6682965492936 0.215965529431047 no 731 0.251972157793482 280 1419823 SGTC_2536 dehydroabietamide 32.04 µM 0.667528298941748 0.216234456140743 no 732 0.25221736990788 277 3983547 SGTC_179 1273-0063 6.77 µM 0.667439414415617 0.216265582756189 no 733 0.252245748418353 294 3108139 SGTC_2955 9076254 12.21 µM 0.66698499463762 0.216424757277135 no 734 0.25239085910263 265 16459619 SGTC_2849 9019321 12.99 µM 0.665157260047695 0.217065661980083 no 735 0.252974956979392 281 16489627 SGTC_1334 1486-0610 236 µM 0.665108927052168 0.217082625068714 no 736 0.252990412633767 261 3742339 SGTC_1043 0916-0009 19.3 µM 0.664076667517609 0.217445092703314 no 737 0.253320621390397 298 3101130 SGTC_2629 bisabolol 100 µM 0.662930410020928 0.217847998695559 no 738 0.253687562190308 300 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1229 0139-0193 12.2 µM 0.661388486611655 0.21839065861416 no 739 0.254181603791621 286 3090752 SGTC_319 1348-1596 45.5 µM 0.660591891148446 0.218671314795534 no 740 0.254437035327538 289 5380505 SGTC_2428 5615643 7.78 µM 0.659164143166974 0.219174857517666 no 741 0.25489518483385 300 2253075 SGTC_3270 9137563 49.47 µM 0.658743559021577 0.219323317488199 no 742 0.255030228197764 269 17015724 SGTC_879 0831-1030 162 µM 0.657346698603656 0.219816803018912 no 743 0.255479007916676 289 1549252 SGTC_2756 carbadox 75.1 µM 0.657328266211575 0.219823319107506 no 744 0.255484932585199 280 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_278 4092-0821 23.9 µM 0.656455043183878 0.220132141740746 no 745 0.255765692279118 279 877900 SGTC_670 4204-0025 119 µM 0.65634487541413 0.220171121164585 no 746 0.255801124988829 282 719039 SGTC_2407 paclitaxel 400 µM 0.655401129447624 0.220505198351581 no 747 0.256104762251677 326 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1757 st041620 31.8375 µM 0.655085661023126 0.220616935949255 no 748 0.256206301774191 295 5289815 SGTC_284 0988-0104 32.6 µM 0.654818051041866 0.220711747710322 no 749 0.256292453597316 292 4666532 SGTC_1136 pergolide 1.05886 µM 0.654657195905872 0.220768748437033 no 750 0.256344245041835 294 47811 A dopamine receptor agonist. SGTC_1616 st002734 56.1 µM 0.654275574062168 0.22090401391247 no 751 0.256467139819011 280 4026101 SGTC_814 3342-0569 96 µM 0.652822332170711 0.221419548167804 no 752 0.256935412335341 288 4346283 SGTC_3010 9080089 71.4286 µM 0.649478745986178 0.222608286171938 no 753 0.258014489960161 274 17027233 SGTC_2478 5763493 32.33 µM 0.647610125461393 0.223274214522012 no 754 0.258618573313294 289 1365576 YLR208W SEC13 SGTC_1411 3909-8223 150 µM 0.647175822948975 0.223429151007032 no 755 0.258759078436922 291 X1411 SGTC_2742 clothiapine 36.27 µM 0.646891947821192 0.223530455896256 no 756 0.258850938787101 275 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2643 anethole 100 µM 0.64672284863271 0.22359081376874 no 757 0.258905666324996 315 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2710 st078562 53.7235 µM 0.64632449424774 0.223733038089832 no 758 0.25903461404587 299 17250908 SGTC_767 0929-0023 86 µM 0.646036323524964 0.223835955630561 no 759 0.25912791590148 303 1204563 SGTC_2588 indole-3-carbinol 100 µM 0.645452320541723 0.224044609459563 no 760 0.259317053481129 287 3712 Induces cell cycle arrest. SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.644046104459006 0.224547478404662 no 761 0.259772768835551 249 4000243 SGTC_3320 9137005 35.139 µM 0.643750343818888 0.224653325135735 no 762 0.25986866917122 280 4908713 SGTC_2270 7924575 90.91 µM 0.641177474525893 0.225575295908358 no 763 0.260703691427783 303 1262135 SGTC_1967 st070177 51.4 µM 0.64112506692786 0.225594098051702 no 764 0.260720714601442 303 5729214 SGTC_1203 3992-3522 103 µM 0.640612671648196 0.225777975546397 no 765 0.260887182312712 315 5322312 SGTC_3195 9113082 49.47 µM 0.640489965007013 0.22582202246808 no 766 0.260927055533738 281 17018038 SGTC_443 clozapine 122 µM 0.638442235570533 0.226557794757544 no 767 0.261592922422042 303 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1027 k015-0025 8.67 µM 0.636669074096239 0.227196003510524 no 768 0.262170210931836 286 3598955 SGTC_694 1315-0438 43.2 µM 0.636162031962531 0.227378687815204 no 769 0.262335408672801 286 6793154 SGTC_3307 9126885 69.2785 µM 0.635618570785753 0.227574585538234 no 770 0.262512531156918 274 24824909 SGTC_2212 7123476 200 µM 0.635161578427444 0.227739387970109 no 771 0.262661519468556 271 1085715 SGTC_1875 nocodazole 6 µM 0.634090824563029 0.228125790518996 no 772 0.263010775216517 282 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2211 7117706 200 µM 0.632023530028048 0.228872856267232 no 773 0.263685750928987 284 822771 SGTC_1454 4239-0054 42.6 µM 0.631838588104028 0.228939756250657 no 774 0.263746177860153 301 1340767 SGTC_3155 9099265 49.47 µM 0.631663728570209 0.229003019170767 no 775 0.263803317019854 297 25236499 SGTC_2177 5811945 192 µM 0.631367438162185 0.229110237293404 no 776 0.263900150768845 282 5343475 SGTC_2207 7258803 200 µM 0.63115090798722 0.229188610516006 no 777 0.26397092870443 305 3666799 SGTC_37 0566-0070 1.56 µM 0.630999922879045 0.229243268559337 no 778 0.264020287431315 295 1626686 SGTC_2226 7298446 200 µM 0.630885226859477 0.229284794492504 no 779 0.26405778599088 299 3283010 SGTC_3183 9108214 49.47 µM 0.628818426451134 0.230033806210293 no 780 0.26473396759941 271 4974831 SGTC_2137 5261020 140 µM 0.628750658625597 0.230058388538568 no 781 0.264756153655753 295 763655 SGTC_2549 cedrol 20.94 µM 0.626885703734736 0.23073546509697 no 782 0.265367079564334 288 6708665 A sedative which affects the nervous system. SGTC_119 0121-0043 24.815 µM 0.626354964645294 0.230928354521135 no 783 0.265541070896278 306 1092378 SGTC_377 3970-0964 33.1 µM 0.625113537757664 0.231379884502723 no 784 0.265948271710185 284 16481235 SGTC_21 0849-0113 22.993 µM 0.623962016070346 0.231799154087118 no 785 0.266326265311884 277 1560156 SGTC_2798 7813637 45.45 µM 0.620975590194788 0.232888482803412 no 786 0.26730784198185 292 956368 SGTC_1012 4112-3522 18 µM 0.620131881020782 0.233196748580139 no 787 0.267585482127152 298 3112398 SGTC_396 dithiazanine 1.25 µM 0.617885111894881 0.234018753574577 no 788 0.268325536823102 281 10578 An antihelmenthic. SGTC_2515 chrysin 20.77 µM 0.617088327969074 0.234310650715496 no 789 0.268588233503048 294 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2479 5617353 43.85 µM 0.61697849744624 0.234350902283923 no 790 0.268624454349664 313 2731746 SGTC_2388 9080168 200 µM 0.616637795032483 0.234475789973903 no 791 0.268736829713278 317 15943073 SGTC_196 k015-0023 18.111 µM 0.615127635478294 0.235029796302285 no 792 0.269235216391284 289 5211998 SGTC_2093 5331342 194.4 µM 0.615092269704405 0.235042778997083 no 793 0.269246893446842 303 33839 SGTC_1624 st003710 6.25 µM 0.614526001086979 0.235250708860731 no 794 0.2694338983575 317 24207033 SGTC_1989 st071868 50.2 µM 0.61442789713798 0.235286742261544 no 795 0.269466302884221 303 16414057 SGTC_715 0868-0130 184 µM 0.613162843874629 0.235751666888712 no 796 0.269884335121613 309 2876258 SGTC_2000 st075254 36.4 µM 0.612847471468315 0.235867649459333 no 797 0.269988599313575 282 17234175 SGTC_1893 st059353 36.1 µM 0.612214988791993 0.236100348491292 no 798 0.270197762978955 326 3112488 SGTC_1050 3232-1156 69.3 µM 0.612200935227469 0.236105520425937 no 799 0.270202411449445 298 700529 SGTC_3126 9127922 49.47 µM 0.611513458408505 0.236358598990579 no 800 0.270429855653391 331 45595682 SGTC_3303 9125618 40.5795 µM 0.609235621059441 0.237198197930112 no 801 0.271184136317616 300 22695467 SGTC_1889 st059080 5.18 µM 0.609227566150758 0.23720116983151 no 802 0.271186805471646 288 176925 Isolated from Daphnopsis sellowiana. SGTC_352 k048-0007 5.11 µM 0.608750767490275 0.237377123668594 no 803 0.271344825512296 317 6811911 SGTC_744 1594-0068 283 µM 0.606771218971769 0.238108405742791 no 804 0.272001375430758 311 668392 SGTC_2074 5212007 75.395 µM 0.605390845722414 0.238619071038285 no 805 0.272459666048671 283 758611 SGTC_3264 9137442 49.47 µM 0.60039188677985 0.240473428043118 no 806 0.274122546788133 293 17015726 SGTC_3055 9094636 49.47 µM 0.599163402193453 0.240930331054982 no 807 0.274531962667876 298 25236176 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.597161705739357 0.241675820616733 no 808 0.275199711742479 293 2333 A French combination drug. SGTC_1296 1068-0102 11.9 µM 0.597110799119656 0.241694796025568 no 809 0.275216704183221 312 767053 SGTC_2213 7173844 200 µM 0.596904917682946 0.241771546443594 no 810 0.275285431911194 302 892728 SGTC_1306 1185-0270 9.02 µM 0.5963905504256 0.2419633548961 no 811 0.275457175863654 305 1548076 SGTC_2700 st077718 96.8 µM 0.596366718072927 0.241972244022578 no 812 0.275465134611986 300 904970 SGTC_2100 5377183 190 µM 0.596084967414613 0.242077346410178 no 813 0.275559233038622 301 2844202 SGTC_899 1083-0020 478 µM 0.595711498081079 0.242216701067269 no 814 0.275683987813152 313 767123 SGTC_1802 st050112 57.9 µM 0.59286080555161 0.243281826884207 no 815 0.276637155141805 304 4662563 SGTC_1351 1496-0003 46.5 µM 0.592710844131995 0.243337928109345 no 816 0.276687341438116 302 3891978 SGTC_1685 st024049 53.0905 µM 0.59222539877309 0.243519583286601 no 817 0.27684983184384 320 1941139 SGTC_974 1326-0144 138 µM 0.591427965693789 0.24381814417084 no 818 0.277116853551372 310 5411856 SGTC_581 0958-0271 211 µM 0.589926611757609 0.244380790444266 no 819 0.277619925993581 288 4591145 SGTC_402 epigallocatechin gallate 10 µM 0.589340176538987 0.244600752346448 no 820 0.277816549328987 310 65064 An antioxidant. SGTC_1941 st076221 61.8 µM 0.588585607642923 0.244883935133706 no 821 0.27806964546347 288 2828568 SGTC_2483 5729050 27.16 µM 0.58751092196266 0.245287559213187 no 822 0.278430308664529 317 2865180 SGTC_961 1252-1571 372 µM 0.587464304731416 0.245305075525946 no 823 0.27844595850715 331 6813498 SGTC_749 1000-0129 128 µM 0.586804440451489 0.245553090049906 no 824 0.278667527106815 315 708470 SGTC_336 4111-0029 111 µM 0.586567350625325 0.245642234772804 no 825 0.278747157861046 318 3131175 SGTC_2151 5563267 85.4165 µM 0.586408469928551 0.245701982934702 no 826 0.278800526912517 332 5310824 SGTC_2886 9058944 51.95 µM 0.584166682952327 0.246545853334163 no 827 0.27955408728652 267 4949929 SGTC_2331 7980721 200 µM 0.58394796185378 0.246628269037301 no 828 0.279627661704472 311 2981221 SGTC_112 phenothiazine 287.218 µM 0.583900019236303 0.246646336136283 no 829 0.279643790120386 328 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1651 st011928 86.1 µM 0.581211638905373 0.247660581346667 no 830 0.280548912177782 305 720198 SGTC_2781 5567276 71.43 µM 0.579843462382785 0.248177607285273 no 831 0.281010092639457 320 2853274 SGTC_2309 7664088 163.95 µM 0.577583401248626 0.249032930482398 no 832 0.281772708045775 308 704922 SGTC_2305 7443522 69.23 µM 0.577083027279721 0.249222509527136 no 833 0.281941684671554 306 5415886 SGTC_1369 1866-0067 208 µM 0.577054155963004 0.2492334504804 no 834 0.281951436024004 313 3531355 SGTC_2600 tangeritin 87.95 µM 0.576857943865618 0.249307812960819 no 835 0.282017711406773 319 68077 A bioactive flavone. SGTC_2843 9000894 45.46 µM 0.575785975548349 0.249714286724356 no 836 0.282379927045152 254 2242070 SGTC_2506 ethyl hematommate 54.16 µM 0.575256779219596 0.249915079445696 no 837 0.282558823741871 315 3940691 An allergen. SGTC_662 k832-1615 104 µM 0.574810982687877 0.250084294297092 no 838 0.282709569111587 322 5878478 SGTC_3061 glucosamine 200 µM 0.574736660409112 0.250112511358563 no 839 0.28273470482674 300 91431 and experimental redox chemotherapeutic SGTC_3105 9121040 49.47 µM 0.574461472892966 0.250217003253069 no 840 0.282827782297301 271 41448907 SGTC_1755 st041960 45.185 µM 0.573944913995675 0.250413209160149 no 841 0.283002539241681 331 2257073 SGTC_3262 9137218 49.47 µM 0.57326584047641 0.250671267429514 no 842 0.283232355310222 276 17650664 SGTC_2620 irigenin 100 µM 0.57242387812014 0.250991421411006 no 843 0.283517421425348 316 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_3129 9127257 49.47 µM 0.571540426456501 0.251327584079234 no 844 0.283816682464701 327 837894 SGTC_1209 2323-2347 50.3 µM 0.571191329948991 0.251460484560064 no 845 0.283934977332816 305 5412760 SGTC_2618 avocadyne 43.43 µM 0.57035510692088 0.251778984296461 no 846 0.284218435845083 311 3015189 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.568885160808276 0.252339371683975 no 847 0.28471703819222 308 688669 SGTC_617 3770-0098 35 µM 0.568602375460404 0.25244725327217 no 848 0.284813006196715 316 5962639 SGTC_2882 9058044 58.44 µM 0.568369407726306 0.252536147878008 no 849 0.284892079342848 295 18076804 SGTC_1738 st035555 74 µM 0.568130032888995 0.252627504448781 no 850 0.284973338073788 341 5331140 SGTC_1525 8-methoxypsoralen 92.5 µM 0.567630669261093 0.252818140855328 no 851 0.285142888766947 350 4114 Related to psoralen; DNA damaging agent. SGTC_1335 1486-0900 202 µM 0.567426038122096 0.252896282441999 no 852 0.285212381784866 305 X1335 SGTC_2891 9063876 19.48 µM 0.567201746845434 0.252981946158912 no 853 0.285288560682352 311 6472478 SGTC_1441 4106-0040 13 µM 0.565545672856518 0.253614923880027 no 854 0.285851333942995 313 2904180 SGTC_330 1488-0319 80.1 µM 0.56490193655835 0.253861194434719 no 855 0.286070233208185 319 6846614 SGTC_1048 3161-0300 24.5 µM 0.56349532131138 0.254399751759454 no 856 0.286548822560452 305 2165101 SGTC_1444 4112-3581 28 µM 0.562983697239979 0.254595788051506 no 857 0.286722992625419 310 2877249 SGTC_2246 7293507 91.5585 µM 0.562681729584734 0.254711528524189 no 858 0.286825813772458 312 887656 SGTC_1352 1496-0991 99 µM 0.562448880300933 0.254800795588712 no 859 0.2869051117796 340 3000039 SGTC_884 0851-0618 334 µM 0.561981933015685 0.254979857776621 no 860 0.287064164345477 327 9642473 SGTC_2050 5263056 171 µM 0.561646842948137 0.255108396703165 no 861 0.287178329156417 309 763468 YGL055W OLE1 SGTC_3230 9131665 49.47 µM 0.560743413685417 0.255455116582422 no 862 0.287486233533864 322 15943720 SGTC_415 dibenzyl ketone 100 µM 0.560267994835543 0.255637672604267 no 863 0.287648327198153 336 7593 SGTC_1096 rimcazole 32.2 µM 0.560018410082847 0.255733537886101 no 864 0.287733440200169 339 18528119 A dopamine reuptake inhibitor. SGTC_38 0929-0051 58.268 µM 0.559333058571385 0.255996877295134 no 865 0.287967218879185 332 1379719 SGTC_3205 9113483 49.47 µM 0.558488342828412 0.256321645337589 no 866 0.288255481237719 350 17018033 SGTC_1486 3970-0793 4.53 µM 0.558220794054058 0.256424554634683 no 867 0.28834681161361 341 2844330 SGTC_2320 7373003 200 µM 0.557942313380486 0.256531691611911 no 868 0.288441888188322 294 5415828 SGTC_653 0203-0016 55.2 µM 0.557457832277007 0.256718136549331 no 869 0.288607330936565 332 295302 SGTC_2845 9003024 42.97 µM 0.552345999942555 0.258689635519829 no 870 0.290355660091293 296 2990173 SGTC_397 arbidol 50 µM 0.551705893859271 0.258937058563864 no 871 0.290574935617512 315 131410 A RNA synthesis inhibitor. SGTC_3065 9113888 49.47 µM 0.550972060552015 0.259220860946644 no 872 0.290826413745191 324 16648368 SGTC_3342 9147791 14.508 µM 0.550555136515272 0.25938217356115 no 873 0.290969335202551 311 1838168 SGTC_2511 berberine 10.47 µM 0.549716614985782 0.259706763969314 no 874 0.291256879510394 326 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1615 st002656 86.5 µM 0.549601691987299 0.259751266817 no 875 0.29129629903333 309 1584458 SGTC_88 0180-0332 8.668 µM 0.547530958750108 0.260553812508101 no 876 0.292007003638541 313 3101745 SGTC_3190 9110366 49.47 µM 0.545379025385648 0.261389179225259 no 877 0.292746431523403 333 17123768 SGTC_188 3229-0966 278.469 µM 0.544477525203637 0.261739544181529 no 878 0.293056455077305 336 5722370 SGTC_1606 st000094 49.2 µM 0.544157606524484 0.26186393737826 no 879 0.293166510875488 315 1242210 SGTC_640 3381-0960 37.1 µM 0.542718818262779 0.262423752458465 no 880 0.29366170775212 324 1745025 SGTC_3341 9147222 25.867 µM 0.542556903030472 0.26248679005103 no 881 0.293717459372947 323 1939759 SGTC_1354 1498-1681 81 µM 0.54190174531747 0.26274193822039 no 882 0.293943097187671 320 5754243 SGTC_254 nsc-64875 3.808 µM 0.541225912841916 0.263005270952476 no 883 0.294175939392341 322 56993 SGTC_2415 st077333 57.7 µM 0.539215215652653 0.263789519982361 no 884 0.294869181305786 355 2766255 SGTC_821 1114-0266 29.2 µM 0.539134020519847 0.263821214230218 no 885 0.294897191321121 322 3123235 SGTC_225 nsc-122657 1.016 µM 0.538369382294535 0.2641197834095 no 886 0.295161029924538 330 275685 SGTC_2969 9091408 28.7 µM 0.537536990117697 0.26444500412854 no 887 0.295448370540475 322 4286311 SGTC_3162 9099653 49.47 µM 0.535916134008627 0.265078866819361 no 888 0.296008256678824 300 25237511 SGTC_2983 9022671 12.99 µM 0.534230507013842 0.265738876912107 no 889 0.296591032467555 349 6405161 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.533717623452965 0.265939862516139 no 890 0.296768457142147 330 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1552 6-methylflavone 10.6 µM 0.531674377614943 0.266741320761848 no 891 0.297475770470014 332 689013 SGTC_1666 st014829 29 µM 0.531038094217545 0.266991150426437 no 892 0.297696190683863 334 3858230 SGTC_3240 9133527 49.47 µM 0.530764584658724 0.267098577246175 no 893 0.297790962296502 349 17617455 SGTC_1004 4084-0029 199 µM 0.530542854163972 0.267185682728028 no 894 0.297867802457809 342 716894 YLR208W SEC13 SGTC_365 0121-0052 13.6 µM 0.529955180536586 0.267416616092302 no 895 0.298071503040667 283 3101739 SGTC_1634 st006576 41 µM 0.529108931263506 0.26774933661597 no 896 0.298364943076578 339 3915356 SGTC_2089 5281248 129.67 µM 0.528352233129788 0.268047024791352 no 897 0.298627442226251 322 2737878 SGTC_1871 st057448 67.3 µM 0.528309621012494 0.268063793528846 no 898 0.298642227524697 357 691747 SGTC_2898 9056270 58.44 µM 0.528202048676794 0.268106127786667 no 899 0.298679553813216 307 19154699 SGTC_3117 9124945 49.47 µM 0.52727921358244 0.268469440581593 no 900 0.298999853446016 312 17592065 SGTC_1878 temozolomide 1 mM 0.526124080386652 0.268924555847742 no 901 0.299400999285827 323 5394 DNA alkylating agent. SGTC_1760 st045453 10.4495 µM 0.526034241811725 0.268959967913141 no 902 0.299432207966183 342 3323419 YIL048W NEO1 SGTC_1558 st069300 45.6 µM 0.52528763058902 0.269254353472895 no 903 0.299691627439111 334 24208000 SGTC_1491 4138-0063 26.5 µM 0.524027184256076 0.269751708429006 no 904 0.300129816249288 344 23883227 SGTC_1678 st019265 80.2 µM 0.52372602468431 0.269870609953941 no 905 0.300234555965431 338 5367020 SGTC_2749 bexarotene 57.39 µM 0.523624638473128 0.269910644386814 no 906 0.300269820601035 328 82146 An retinoic acid receptor inhibitor. SGTC_784 4579-0127 173 µM 0.523429880915648 0.269987556757282 no 907 0.300337567355896 336 1948547 SGTC_483 fpl-64176 144 µM 0.523225965893135 0.270068097285188 no 908 0.300408506952194 343 3423 SGTC_796 1234-0020 70.7 µM 0.522311169126699 0.27042956337151 no 909 0.300726846916313 318 46495034 SGTC_2525 harmine 47.85 µM 0.520272343930499 0.271236038730618 no 910 0.301436884447657 335 5280953 A monoamine oxidase inhibitor SGTC_1273 0849-0096 14.1 µM 0.520049179233584 0.271324386246496 no 911 0.301514649171428 339 5286025 SGTC_1238 0333-0287 48.8 µM 0.519921993393248 0.271374743605008 no 912 0.301558972816698 326 7226 SGTC_369 0957-0393 4.5 µM 0.519906343087327 0.271380940434695 no 913 0.301564427074545 330 6997992 SGTC_1587 estradiol valerate 56.1 µM 0.519285678222598 0.271626753129683 no 914 0.301780769555907 356 13791 A steroid. SGTC_2463 5473429 200 µM 0.517935452281493 0.272161889197491 no 915 0.302251652799713 346 5399405 SGTC_1667 st014849 34.6 µM 0.516665424920377 0.272665717927481 no 916 0.302694867928008 314 5348460 SGTC_1031 k035-0009 16 µM 0.51590753636009 0.272966597988857 no 917 0.302959495100981 357 5180959 SGTC_2960 9079389 5.97 µM 0.515420095515582 0.273160197859216 no 918 0.303129746440418 321 16457355 SGTC_3090 9117696 49.47 µM 0.514947652632253 0.273347905805809 no 919 0.303294800178413 333 7923821 SGTC_2268 7933382 153.85 µM 0.513841339837002 0.273787708615561 no 920 0.303681461255374 317 935025 YOR257W CDC31 SGTC_1264 0783-0040 158 µM 0.512118085615908 0.274473466223567 no 921 0.304284183853165 352 2855798 SGTC_916 4466-0038 42 nM 0.51169919713059 0.274640288090435 no 922 0.30443077405813 340 5722064 YGL116W CDC20 SGTC_2951 9072950 58.06 µM 0.510292039639053 0.275201052864626 no 923 0.304923439403035 331 16488155 SGTC_2147 5545932 89.7195 µM 0.50897433806006 0.275726679252872 no 924 0.305385105866357 358 797404 SGTC_220 paclitaxel 373.376 µM 0.50783320455049 0.27618227161913 no 925 0.305785160684572 335 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2980 9014342 25.29 µM 0.507178707522773 0.276443743203318 no 926 0.306014716762948 344 2996599 SGTC_1187 1391-0724 117 µM 0.506857375267962 0.276572159865254 no 927 0.306127447652045 336 6997986 SGTC_2641 levomentholum 100 µM 0.50564847813675 0.277055543188465 no 928 0.306551721523417 344 16666 SGTC_3151 9099821 49.47 µM 0.505260405860847 0.27721080337886 no 929 0.306687974184744 344 17174189 SGTC_477 mead ethanolamide 10 µM 0.505187762734865 0.277239871213236 no 930 0.306713482246417 314 16061185 SGTC_279 1273-0055 2.93 µM 0.504739052003777 0.277419453922011 no 931 0.30687106423225 350 2847562 SGTC_1338 1486-1223 76 µM 0.504206282801634 0.277632752273411 no 932 0.307058212922452 335 3444526 SGTC_1126 isoteolin 1.0172 µM 0.503998624451222 0.277715911625775 no 933 0.307131171803324 319 133323 SGTC_2420 aureobasidin a 50 nM 0.502035254430484 0.278502768117133 no 934 0.30782136116712 316 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2188 6126565 140.678 µM 0.500969837730616 0.278930207480046 no 935 0.308196175315437 333 874518 SGTC_3214 9129694 49.47 µM 0.500965000837321 0.278932148742738 no 936 0.308197877393548 376 17158655 SGTC_2261 9010538 184.68 µM 0.500513916560422 0.279113218021667 no 937 0.308356629776198 356 6457250 SGTC_3334 9142812 21.919 µM 0.497627055532911 0.280273381244806 no 938 0.309373465214642 354 45283678 SGTC_2004 4023728 41.89 µM 0.496926087899649 0.280555436089323 no 939 0.309620586974666 361 360084 YDR527W RBA50 SGTC_1930 st074634 34.3 µM 0.496184202996033 0.280854104736706 no 940 0.309882227640516 329 684253 YOR116C RPO31 SGTC_2678 equilin 100 µM 0.495963070862002 0.280943158024556 no 941 0.309960232985753 319 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_3261 9137475 49.47 µM 0.494859828275225 0.281387654438445 no 942 0.310349534484723 320 17027690 SGTC_742 0kpi-0133 140 µM 0.494232286850037 0.281640642208559 no 943 0.310571070071213 364 2728852 SGTC_1735 st034310 56.75 µM 0.493255598356357 0.282034603582008 no 944 0.31091599874668 341 871153 SGTC_1905 st060207 84.5 µM 0.493176760487667 0.282066415544036 no 945 0.310943848491825 329 1948547 SGTC_643 k048-0106 28.4 µM 0.493138685732324 0.28208177975249 no 946 0.310957298916366 344 6763920 SGTC_2492 derrusnin 100 µM 0.492653718849425 0.28227751244232 no 947 0.311128642145409 367 1715307 Part of coumarin class of compounds. SGTC_331 k048-0133 24.5 µM 0.492050751141635 0.28252096138252 no 948 0.311341733237433 331 6813582 SGTC_2582 agaric acid 100 µM 0.491944266650597 0.282563965110369 no 949 0.311379371834535 316 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2411 st077133 39.94 µM 0.491794060325179 0.282624631236785 no 950 0.31143246794524 352 1403142 YNL221C POP1 SGTC_1881 5652484 16 µM 0.491748756809095 0.282642929889613 no 951 0.311448482957599 345 2255129 SGTC_934 2950-0684 338 µM 0.490429645960324 0.283175984655715 no 952 0.311914951366742 373 1121253 SGTC_3315 9136395 68.55 µM 0.489043549573631 0.283736627540851 no 953 0.312405432669112 386 16876844 SGTC_1452 4194-0072 190 µM 0.488335242302337 0.284023325982728 no 954 0.312656201315509 343 1343545 SGTC_221 trifluoperazine 10.304 µM 0.487749632861656 0.284260465171388 no 955 0.31286359561905 349 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1003 4049-0218 100 µM 0.487492024733059 0.284364812074915 no 956 0.312954846621412 343 295161 SGTC_1292 0kpi-0043 232 µM 0.486819786560652 0.284637195446987 no 957 0.31319302353101 353 3333905 SGTC_2231 micatex 6.853 µM 0.486614163134047 0.284720536626237 no 958 0.313265892379432 350 20737 An antifungal of unknown mechanism. SGTC_1423 4048-0112 5.59 µM 0.485973136236283 0.284980425803303 no 959 0.313493106336357 348 X1423 SGTC_1412 3909-8563 178 µM 0.485451555215156 0.285191971916805 no 960 0.313678034573191 359 23767530 SGTC_291 SEC14.278 35.5 µM 0.484780931533217 0.285464077607675 no 961 0.313915875176579 336 1068044 SGTC_2045 5106652 78.05 µM 0.483919421615333 0.285813816713323 no 962 0.314221528174446 336 673349 SGTC_2848 9016370 25.97 µM 0.481282706976433 0.286885483349878 no 963 0.315157792950764 339 7894410 SGTC_2461 5755302 26.15 µM 0.480167133562415 0.287339469648101 no 964 0.315554277481907 370 2788904 SGTC_2316 5844804 197.44 µM 0.480011520726487 0.287402823810428 no 965 0.31560960053453 355 776813 SGTC_1114 scopoletin 1.73284 µM 0.479931777788394 0.287435291861205 no 966 0.31563795212874 359 5280460 A coumarin with genotoxic properties. SGTC_1778 st046819 58.9 µM 0.47977136116725 0.287500612178476 no 967 0.315694989518572 371 671715 SGTC_373 0844-0104 25.9 µM 0.478998630564246 0.287815359969058 no 968 0.315969801439543 353 5375804 SGTC_739 1486-1183 203 µM 0.478105381409248 0.288179399934227 no 969 0.316287601034908 351 4346692 SGTC_2090 5301565 104.445 µM 0.477558719873808 0.288402296657055 no 970 0.316482158888887 352 2056344 SGTC_2341 7987486 176.74 µM 0.477335883677437 0.288493179585097 no 971 0.316561481280793 354 1258686 SGTC_223 busulfan 5 mM 0.476641040312411 0.288776655533362 no 972 0.316808876936725 342 2478 A DNA alkylator. SGTC_724 3910-0327 137 µM 0.474817511359348 0.289521225490576 no 973 0.31745852519514 375 2885483 SGTC_2647 atorvastatin 60.16 µM 0.473343973649305 0.290123547392256 no 974 0.317983897159602 349 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2748 diazoxide 86.69 µM 0.47331991460592 0.290133386614771 no 975 0.317992478162995 336 3019 A potassium channel activatior. SGTC_271 rotenone 740 µM 0.472471334346755 0.290480523250328 no 976 0.318295198977763 367 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1759 st043059 70 µM 0.472103949899916 0.290630872906905 no 977 0.318426296631362 364 669426 SGTC_2659 sanguinarine 24.21 µM 0.471419711999201 0.290910989742854 no 978 0.318670521038564 355 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2292 7671323 168.05 µM 0.470923120721131 0.291114365822532 no 979 0.318847818255605 375 937504 SGTC_704 1310-0270 142 µM 0.468951548659245 0.291922466145718 no 980 0.319552134380061 365 5718033 SGTC_661 1304-0007 33.6 µM 0.467703304064406 0.292434631289917 no 981 0.319998388982286 354 3117130 SGTC_454 lyso-paf C-16 6.67 µM 0.46690455046043 0.292762585562211 no 982 0.320284084746605 364 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_86 0417-1630 471.922 µM 0.46578320165868 0.293223279736151 no 983 0.320685345168397 347 3634867 SGTC_773 4358-1457 44.6 µM 0.4656835547384 0.293264234863392 no 984 0.320721012700766 372 1186886 SGTC_265 mycophenolic acid 32.932 µM 0.465509540230401 0.293335761608082 no 985 0.32078330327191 353 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2930 9013230 14.89 µM 0.464887945976264 0.293591327064755 no 986 0.321005851553557 359 2995857 SGTC_996 3970-0799 1.8 µM 0.464655539422509 0.293686906360546 no 987 0.321089076180715 366 6615648 YGL040C HEM2 SGTC_3118 9124250 49.47 µM 0.4642198476965 0.293866127316929 no 988 0.321245121304089 367 1504786 SGTC_2310 7668677 200 µM 0.463946029648391 0.293978787726966 no 989 0.321343206731298 389 2197143 SGTC_2899 9053889 58.44 µM 0.463880744760447 0.294005651659091 no 990 0.321366594524675 345 6470052 SGTC_1448 4255-0083 152 µM 0.462319720860626 0.294648331609938 no 991 0.321926029725713 380 5399660 SGTC_2854 9024559 71.43 µM 0.460601699514751 0.295356396174964 no 992 0.322542196031352 353 3163529 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.459889842739034 0.295650009741149 no 993 0.322797645623382 349 17037758 SGTC_1954 st077032 68.9 µM 0.459805671590983 0.295684735972929 no 994 0.322827855946451 374 698907 SGTC_957 1187-1561 14.1 µM 0.459418249922022 0.295844597505167 no 995 0.322966922631741 347 1538454 SGTC_335 4077-0256 27.6 µM 0.458668773495448 0.296153966065365 no 996 0.323236020689549 358 3121989 SGTC_730 1436-0052 41.2 µM 0.458451653475625 0.296243616494814 no 997 0.323313994500864 328 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2119 5528445 120.635 µM 0.45737401844881 0.296688763899424 no 998 0.323701117889121 349 791935 SGTC_339 3091-4833 71.4 µM 0.456925635053651 0.296874071445697 no 999 0.32386224879866 343 3240077 SGTC_2115 tiliquinol 12.7705 µM 0.456805947914925 0.296923544609332 no 1000 0.323905265113194 378 71208 A bioactive hydroxyquinoline. SGTC_2995 9067767 71.4286 µM 0.455342077712374 0.297528946259391 no 1001 0.324431579472048 349 11673567 SGTC_2476 5806916 10.51 µM 0.455193071323646 0.297590601284958 no 1002 0.324485172359702 357 2870194 SGTC_485 niflumic acid 177 µM 0.454181563768198 0.29800929126607 no 1003 0.324849075698907 365 4488 A COX2 inhibitor. SGTC_2348 9022543 33.42 µM 0.45244375744247 0.298729241812889 no 1004 0.325474664974922 375 3162678 YDL140C RPO21 SGTC_1827 berberine 7.24 µM 0.451454770537813 0.299139318906451 no 1005 0.325830908108168 354 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_301 4119-0100 24.5 µM 0.450648577451031 0.29947379062512 no 1006 0.326121424765394 375 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_734 2023-0417 80 µM 0.449450226823102 0.29997127289391 no 1007 0.326553452851596 381 3935732 SGTC_2908 7930301 100 µM 0.448657174217526 0.300300705576349 no 1008 0.326839491343762 335 2223178 SGTC_577 r071-0003 38.6 µM 0.448339537937915 0.300432696984644 no 1009 0.326954085066698 367 4568517 YMR134W ERG29 SGTC_2101 5377231 179.231 µM 0.447441679077486 0.30080593726282 no 1010 0.327278094077423 375 2844213 SGTC_2764 methyldopa 94.69 µM 0.446120893495006 0.301355368192819 no 1011 0.327754960600802 373 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_3164 9100705 49.47 µM 0.444808215982808 0.301901873484319 no 1012 0.328229178209863 365 17174235 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.443653155065288 0.302383126445089 no 1013 0.328646684385113 342 803109 SGTC_1032 k061-1018 98.7 µM 0.44356584875221 0.302419516363455 no 1014 0.328678250667771 367 4005393 SGTC_873 0591-4978 488 µM 0.43956779751437 0.304088033114565 no 1015 0.33012508413519 391 3305145 SGTC_3095 9117207 49.47 µM 0.436413624101338 0.305407259872902 no 1016 0.331268327945444 348 17015229 SGTC_3015 9080845 49.47 µM 0.435881889459695 0.305629906600124 no 1017 0.331461212837234 372 5296973 SGTC_2555 cholic acid 100 µM 0.434999271725917 0.305999632968213 no 1018 0.331781478030059 359 6708657 Influences liver metabolism. SGTC_2437 5741531 144.16 µM 0.434556184458563 0.306185315699263 no 1019 0.331942302314205 361 2262990 SGTC_2512 diallyl trisulfide 49.23 µM 0.434297542292023 0.30629372681447 no 1020 0.332036194167659 388 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2640 pentamidine 10.38 µM 0.433496055686262 0.306629781487214 no 1021 0.332327215476115 356 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_385 1494-0393 12.4 µM 0.432667854830262 0.306977208024042 no 1022 0.332628043020487 366 3090647 SGTC_132 0417-1715 25.805 µM 0.431902069045157 0.307298606031474 no 1023 0.33290629546613 383 6769098 SGTC_1980 st071811 45.7 µM 0.431861459573929 0.307315653841152 no 1024 0.332921053710374 382 4974850 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.431451248126622 0.307487883478041 no 1025 0.333070146760583 352 688662 SGTC_1502 4534-4282 27.7 µM 0.430951230678085 0.307697876089109 no 1026 0.333251915860305 402 3278949 SGTC_1509 1326-1131 80 µM 0.430487363701516 0.307892742916753 no 1027 0.33342057836856 350 768313 SGTC_409 arachidonic acid 100 µM 0.429631417248242 0.308252461437884 no 1028 0.33373188977617 354 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1510 1123-0200 71.5 µM 0.428292048799589 0.308815711611368 no 1029 0.334219253541902 364 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1987 st072290 61.9 µM 0.42584907022495 0.309844225780606 no 1030 0.335108914045386 379 54697379 SGTC_1172 0370-0043 85 µM 0.425738296422787 0.309890897843708 no 1031 0.335149276565716 353 376585 SGTC_919 tnp00227 403.569 nM 0.425719019515711 0.309899020050231 no 1032 0.335156300664195 392 1269246 A methoxyflavone. YNL221C POP1 SGTC_2439 5492030 7.2 µM 0.425443861242264 0.310014966413879 no 1033 0.335256568819986 365 5722370 SGTC_911 3456-4043 236 µM 0.425096694039586 0.31016128290416 no 1034 0.335383093903119 362 914281 SGTC_1118 chelidonine 707.474 nM 0.424614724043602 0.310364462979371 no 1035 0.335558778818171 369 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_683 panaxydol 45 µM 0.424403161964495 0.310453667727187 no 1036 0.335635907561551 351 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1785 bathophenanthroline 24 µM 0.42356263841595 0.310808182980504 no 1037 0.335942403855132 354 72812 An iron chelator. SGTC_1009 4106-0057 9.87 µM 0.421538055699882 0.311662830477277 no 1038 0.3366811141499 381 2928005 SGTC_3318 9139014 38.6185 µM 0.421375010548644 0.311731701807175 no 1039 0.336740631973567 375 16643984 SGTC_115 0527-0192 112.043 µM 0.421074444126632 0.311858680272408 no 1040 0.336850361127892 389 4233931 SGTC_234 nsc-17383 10.7 µM 0.421030489745959 0.311877251286754 no 1041 0.336866408918286 359 408974 SGTC_2220 6782180 200 µM 0.420795862107121 0.311976391094103 no 1042 0.336952076738011 369 833803 SGTC_3016 9080866 49.47 µM 0.419121882569516 0.312684111114039 no 1043 0.337563529480424 376 17066299 SGTC_1845 st056753 3.01 µM 0.419008848740395 0.312731924154356 no 1044 0.337604832711148 341 5375839 SGTC_2152 5568786 200 µM 0.418286828016439 0.313037411523974 no 1045 0.337868709499816 394 5399883 SGTC_2083 5306046 65.942 µM 0.416385941028352 0.313842291436036 no 1046 0.338563807195902 343 539837 SGTC_3111 9122088 49.47 µM 0.41582118626246 0.314081592804702 no 1047 0.338770427320866 362 16876704 SGTC_1799 st045822 46.1415 µM 0.415354795749013 0.314279273622565 no 1048 0.338941096671913 388 3674992 SGTC_384 k007-0144 5.16 µM 0.414548839896078 0.314621005648936 no 1049 0.339236103324376 366 6824886 SGTC_1877 wortmannin 25 µM 0.414488715918945 0.314646505089251 no 1050 0.339258114653346 391 312145 A covalent inhibitor of PI 3-kinase. SGTC_2711 st079103 59.1 µM 0.414179650829234 0.314777597972699 no 1051 0.339371271735025 391 54693780 SGTC_540 1187-0821 17.3 µM 0.413056808337819 0.315254058622388 no 1052 0.339782496562843 395 847520 SGTC_1729 st035615 45.989 µM 0.412916541781225 0.315313600160127 no 1053 0.339833880574008 357 17385451 SGTC_1647 st011722 22.4 µM 0.4127030617675 0.315404229173095 no 1054 0.339912090667715 357 2854783 SGTC_945 3381-0768 11.3 µM 0.411430938026901 0.315944516051279 no 1055 0.340378286051205 389 1126236 YIL048W NEO1 SGTC_679 0422-0091 41.4 µM 0.411337064937661 0.315984400727313 no 1056 0.340412697414003 382 627384 YHR062C RPP1 SGTC_230 MPP+ 141.667 µM 0.407532808857169 0.317602546203782 no 1057 0.341808351162273 367 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2736 butenafine 14.65 µM 0.405989532977538 0.318259977834007 no 1058 0.342375145597331 371 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1318 1280-3875 124 µM 0.404359969111724 0.31895478980986 no 1059 0.342974016333765 375 373245 SGTC_2248 tofa 1.1 µM 0.403091743931982 0.319495975264365 no 1060 0.343440366990244 380 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.403024369710917 0.319524736409205 no 1061 0.343465148456267 375 1241132 A phosphatase inhibitor. SGTC_716 1683-5115 658 µM 0.402978564145925 0.31954429080609 no 1062 0.343481996961888 398 723597 SGTC_2747 doxorubicin 7.63 µM 0.402485515046774 0.319754805238074 no 1063 0.343663373224431 362 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1219 1469-0211 33.1 µM 0.401312288097746 0.320255964843627 no 1064 0.344095108823869 412 6822282 SGTC_19 0279-0214 38.434 µM 0.401259337838646 0.320278590999446 no 1065 0.344114598780342 369 3566274 YBR002C RER2 SGTC_2927 9011802 47.9 µM 0.401170433609408 0.320316582135857 no 1066 0.344147323622504 363 43912568 SGTC_2754 granisetron 64.02 µM 0.40002498448248 0.320806231279265 no 1067 0.344569057396785 399 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1251 0490-5699 265 µM 0.399036719597868 0.321228939006231 no 1068 0.344933074096667 385 3883818 SGTC_173 1273-0061 2.693 µM 0.398997845883694 0.321245571089226 no 1069 0.344947395746473 381 2847414 YPL266W DIM1 SGTC_2075 5212009 200 µM 0.398099822225066 0.321629889435096 no 1070 0.345278302712291 409 780898 SGTC_2109 5483026 200 µM 0.397507989708925 0.321883274598437 no 1071 0.34549644797065 386 759335 SGTC_3314 9135860 59.4275 µM 0.397421318822981 0.32192038853433 no 1072 0.345528398553268 382 25252478 SGTC_557 1315-0110 16.2 µM 0.396952655771479 0.322121108728383 no 1073 0.345701186789657 360 6833801 SGTC_1482 3346-2049 8.48 µM 0.395670207353861 0.322670624115858 no 1074 0.346174168343584 364 3826804 SGTC_264 promethazine 12.5 mM 0.392609820444699 0.323983531130648 no 1075 0.347303842586735 397 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_584 0986-0246 15.4 µM 0.392394448669833 0.32407600845972 no 1076 0.347383393578554 394 53315 YDR232W HEM1 SGTC_831 k061-1017 217 µM 0.392371766606851 0.324085748420858 no 1077 0.347391771950778 406 1240153 SGTC_1080 nisoldipine 24.4 µM 0.392273680989148 0.324127868996334 no 1078 0.347428003985115 401 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2924 9010168 62.78 µM 0.390846071489457 0.324741177128716 no 1079 0.347955509052889 368 2993929 SGTC_3069 9117009 49.47 µM 0.390066090040516 0.325076461990154 no 1080 0.348243838461322 357 41904981 SGTC_167 3672-0051 66.205 µM 0.388822049328863 0.325611521738198 no 1081 0.348703894391556 397 3237971 SGTC_3292 9120825 59.784 µM 0.388630947286968 0.325693746276198 no 1082 0.348774585150503 407 24824900 SGTC_553 k007-0256 45.7 µM 0.388270893781961 0.325848687771145 no 1083 0.34890778718724 365 6287000 SGTC_2914 7968218 45.32 µM 0.382561088019902 0.32830978934245 no 1084 0.351022613258034 381 2977111 SGTC_102 gallobenzophenone 83.616 µM 0.381091527417628 0.328944428091363 no 1085 0.351567667028047 402 70837 SGTC_576 1073-0113 22.7 µM 0.380997496529022 0.328985052722565 no 1086 0.35160255308855 400 5439563 SGTC_1130 3454-2858 15.9 µM 0.380928756788574 0.329014751971782 no 1087 0.351628056762296 432 715628 YIL048W NEO1 SGTC_212 3807-4682 38.772 µM 0.378643743368662 0.330002613472347 no 1088 0.352476217069215 380 3125501 YBL034C STU1 SGTC_682 0kpi-0099 17 µM 0.378488546669323 0.3300697515234 no 1089 0.352533850260726 400 1714895 YML126C ERG13 SGTC_580 1123-0028 41 µM 0.377392146442834 0.330544209770543 no 1090 0.352941101195205 389 1677248 YPR107C YTH1 SGTC_1415 3966-0071 78.1 µM 0.377304026454451 0.330582354815338 no 1091 0.352973840131025 394 2893185 SGTC_1302 1159-0335 255 µM 0.376541141086115 0.330912663258821 no 1092 0.353257317958691 387 649284 SGTC_959 1222-0044 107 µM 0.375621228528225 0.331311135274189 no 1093 0.35359925325514 398 6083612 SGTC_702 1488-0190 94 µM 0.372248305609595 0.332773792164119 no 1094 0.354853991721329 379 949357 SGTC_327 1273-0057 3.96 µM 0.371393847657377 0.333144730539886 no 1095 0.355172103643682 391 3108138 SGTC_2663 amphotericin b 100 µM 0.371217954544808 0.33322110976078 no 1096 0.355237600616509 389 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1271 0832-2808 169 µM 0.370746620816888 0.333425814195046 no 1097 0.35541313131098 400 3663794 SGTC_1705 st027868 56.3335 µM 0.370198595758289 0.333663888737642 no 1098 0.355617261402173 421 292948 SGTC_2335 9018011 154.17 µM 0.369621874940292 0.333914501717218 no 1099 0.355832124906341 415 6458208 SGTC_885 0865-0106 16.8 µM 0.368147765476933 0.33455540981119 no 1100 0.356381528171111 373 2793380 SGTC_575 k072-0246 11.9 µM 0.367175315846429 0.334978472242195 no 1101 0.356744125237863 388 6796779 SGTC_1295 1013-0063 9.78 µM 0.365875808207669 0.335544147614316 no 1102 0.357228874438146 394 6826038 SGTC_3024 9090631 49.47 µM 0.365407867651742 0.335747933426353 no 1103 0.357403484584319 384 25236383 SGTC_292 k038-0015 474 µM 0.365164528696395 0.335853925442803 no 1104 0.357494297344897 374 46368540 SGTC_1386 3228-0095 33.8 µM 0.363169726144971 0.336723300295277 no 1105 0.358239050499479 406 870181 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.362155212084827 0.337165781127742 no 1106 0.358618023291883 403 165506 SGTC_1619 st003326 88.7 µM 0.360125553766571 0.338051693599795 no 1107 0.359376621958212 373 2849032 SGTC_2069 5228469 200 µM 0.360085202613046 0.33806931533051 no 1108 0.359391709110011 403 2835210 SGTC_910 3454-3003 490 µM 0.359166362407668 0.338470677507374 no 1109 0.359735319460349 412 820824 SGTC_2496 diffractaic acid 79.83 µM 0.358106384330557 0.338933918683087 no 1110 0.360131850731831 381 94870 An apoptosis inducer which activates caspases. SGTC_2499 avocadenofuran 51.48 µM 0.357854616348563 0.339043984434382 no 1111 0.360226057723673 386 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1901 st060216 58.6 µM 0.357508333946448 0.339195391626795 no 1112 0.360355644154347 381 688792 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.35717874589317 0.339339523569289 no 1113 0.360478998097708 371 4174840 SGTC_109 0132-0036 33.701 µM 0.357170136808239 0.33934328871789 no 1114 0.360482220389068 414 67274 A color developer. SGTC_1242 0402-0103 60.1 µM 0.35715434657086 0.339350194556264 no 1115 0.360488130537196 373 432868 SGTC_1277 0873-0036 22 µM 0.357076682225576 0.33938416173503 no 1116 0.360517200109349 373 5965735 SGTC_312 4092-0653 6.84 µM 0.356590288733712 0.339596919840859 no 1117 0.360699274317372 377 1148278 SGTC_524 r073-0010 27.8 µM 0.35645720862783 0.339655140614216 no 1118 0.360749096390495 409 2772106 SGTC_2738 aclarubicin 5.55 µM 0.353159318632259 0.341099142701023 no 1119 0.361984502176029 386 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1745 st081495 74 µM 0.352664197282483 0.341316136440228 no 1120 0.362170101650158 379 13842402 YBL026W LSM2 SGTC_3330 9141424 71.43 µM 0.352500569125875 0.341387860270113 no 1121 0.362231445861565 372 27261020 SGTC_3339 9145883 14.936 µM 0.352273589409364 0.341487362745769 no 1122 0.362316546436965 406 2030670 SGTC_738 1315-0003 72.4 µM 0.35207068656952 0.341576319822308 no 1123 0.362392625728106 411 6251474 SGTC_2129 girgensonine 121.053 µM 0.351885452999526 0.341657537985952 no 1124 0.362462084596381 410 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2970 9090938 41.86 µM 0.351606434292426 0.3417798913487 no 1125 0.362566719553055 388 17217104 SGTC_2774 tamoxifen 10.92 µM 0.350922598155725 0.342079832735176 no 1126 0.362823208710419 369 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2885 9057732 51.95 µM 0.350739428276441 0.342160190885346 no 1127 0.362891921427331 382 6471414 SGTC_1070 indatraline 8.81 µM 0.350421004653744 0.342299902991726 no 1128 0.363011382535304 412 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_398 bronopol 33.3 µM 0.34963952259569 0.34264287889346 no 1129 0.363304623021097 406 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_706 4262-0057 46.9 µM 0.349256873293556 0.342810862900108 no 1130 0.363448236188784 400 883298 SGTC_24 0417-1663 219 µM 0.349242549857272 0.342817151528413 no 1131 0.363453612330066 400 4329390 SGTC_2254 7938975 95.19 µM 0.348951030602481 0.34294515096372 no 1132 0.363563036657533 390 2969277 SGTC_591 4299-0174 154 µM 0.347783942344833 0.343457773144178 no 1133 0.3640012249552 416 5509088 SGTC_1596 piperlongumine 63 µM 0.34774539031549 0.34347471133853 no 1134 0.364015702518258 369 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2396 5342950 42.78 µM 0.346575844379761 0.343988711550552 no 1135 0.364454997897687 413 1886677 SGTC_546 peri-Naphthalide 147 µM 0.345910915286208 0.344281067901781 no 1136 0.364704832627943 372 223824 A penicillin ester. SGTC_1333 1482-0047 286 µM 0.345227180843416 0.344581789666251 no 1137 0.364961793048356 416 3811116 SGTC_1267 0828-0272 9.49 µM 0.343876499272854 0.345176138358422 no 1138 0.365469583073436 391 745334 SGTC_3345 9148410 3.559 µM 0.343833579323575 0.345195030957988 no 1139 0.365485722740889 406 4903596 SGTC_3139 9095020 49.47 µM 0.34001522251892 0.346877342862436 no 1140 0.366922532134735 394 25236292 SGTC_1553 gossypol 38.6 µM 0.33965990333548 0.347034045524575 no 1141 0.367056330398512 425 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2186 6124449 200 µM 0.339596012227411 0.347062225520181 no 1142 0.367080390816657 405 3834182 YLR033W RSC58 SGTC_2034 5197015 53.07 µM 0.339410485229908 0.347144059383758 no 1143 0.367150260416692 416 780676 SGTC_1677 st019204 53.9 µM 0.33892545140875 0.347358035994373 no 1144 0.367332945282857 371 3945625 SGTC_1430 4049-0248 69.1 µM 0.338525642175136 0.347534451674238 no 1145 0.36748355344031 411 22774488 SGTC_141 0443-0274 32.331 µM 0.337970988824944 0.347779246949563 no 1146 0.367692525136598 377 1627241 SGTC_2442 5158906 48.48 µM 0.33794926639948 0.347788835395851 no 1147 0.367700710094776 401 1893835 SGTC_1132 3456-3614 2.5 µM 0.337283797683971 0.348082625571997 no 1148 0.367951486221775 380 3125502 SGTC_136 0097-0015 404.482 µM 0.337024096030812 0.348197303037543 no 1149 0.368049367819002 367 4861337 SGTC_644 1498-1197 63.3 µM 0.336225499250871 0.348550029447222 no 1150 0.368350412735702 400 6741615 SGTC_1030 k029-0042 36.7 µM 0.336157277210924 0.34858016802133 no 1151 0.368376133968272 384 6080581 SGTC_2778 tioconazole 65.09 nM 0.334060792938317 0.349506800836003 no 1152 0.36916684243458 407 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2245 6637752 200 µM 0.333758190750458 0.349640623342954 no 1153 0.369281017475853 410 681890 SGTC_2571 chrysanthemic acid 100 µM 0.333630036822912 0.349697303648886 no 1154 0.369329374799686 406 2743 An insecticide. SGTC_1487 3970-0795 2.82 µM 0.333373800467704 0.349810642683029 no 1155 0.369426068666983 382 3765103 SGTC_1139 k015-0024 46.9 µM 0.333225862905026 0.349876084849934 no 1156 0.369481898445266 398 2766652 SGTC_3222 9128301 49.47 µM 0.332646418563167 0.350132452762757 no 1157 0.36970059995492 405 4911358 SGTC_2575 plumbagin 510 nM 0.332295365959077 0.35028780484283 no 1158 0.369833119361117 388 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3199 9111318 49.47 µM 0.33223273749939 0.350315522586723 no 1159 0.369856762703493 411 8548020 SGTC_2192 5915882 198.485 µM 0.332029579015519 0.350405440788178 no 1160 0.369933461981513 387 2876149 SGTC_1156 4092-0367 4.88 µM 0.331105308737158 0.350814629754864 no 1161 0.37028247090413 408 1357585 SGTC_2196 6573537 42.6665 µM 0.330931760683955 0.350891481520526 no 1162 0.370348015407668 420 2903087 SGTC_1119 parthenolide 318.541 nM 0.330874612711865 0.350916789521523 no 1163 0.370369599507243 416 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_23 0213-0011 39.996 µM 0.330172315803906 0.351227855948762 no 1164 0.3706348818833 387 627608 SGTC_191 3914-0123 66.505 µM 0.329943086689102 0.351329409357602 no 1165 0.370721483148615 417 3144412 SGTC_1874 staurosporine 7.6 µM 0.329673373781113 0.35144891154649 no 1166 0.370823387314274 416 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2205 7238770 200 µM 0.329372940988488 0.351582042139415 no 1167 0.370936908875423 409 279867 SGTC_2593 nobiletin 86.24 µM 0.329274792358089 0.351625538625945 no 1168 0.370973997760397 353 72344 An anti-infammatory. SGTC_509 pifithrin 175 µM 0.328466039616682 0.351984027138495 no 1169 0.371279658808698 413 4817 A p53 inhibitor. SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.328274402608851 0.35206899164026 no 1170 0.371352098253068 393 688761 SGTC_2650 prasterone 100 µM 0.327748260004922 0.352302301062704 no 1171 0.371551005381779 402 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_309 k408-0051 1.48 µM 0.325529046523249 0.353286986213682 no 1172 0.372390351370006 407 3640463 SGTC_1903 st060211 78.3 µM 0.325328951323794 0.353375818675674 no 1173 0.372466060798178 385 688960 SGTC_1421 4029-0249 71.4 µM 0.325250630528078 0.353410591446057 no 1174 0.372495696148029 411 2894095 SGTC_7 0192-1582 4.227 µM 0.325045532808609 0.353501656275742 no 1175 0.37257330545643 404 252616 SGTC_3150 9097574 49.47 µM 0.324854524779025 0.353586472725961 no 1176 0.372645587856598 423 17217476 SGTC_133 0724-0033 378.92 µM 0.324174941997294 0.353888298011392 no 1177 0.372902795985458 427 280309 SGTC_1951 sophoraflavanone G 9.2 µM 0.323872376838532 0.354022706809391 no 1178 0.373017328923784 402 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2636 apigenin dimethyl ether 100 µM 0.323787053313689 0.354060613446231 no 1179 0.373049629298468 409 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3231 9132313 49.47 µM 0.320165643057651 0.35567082461255 no 1180 0.374421383165594 402 4905967 SGTC_3329 9141233 27.5565 µM 0.319766984181813 0.355848240987005 no 1181 0.374572488676929 415 4909101 YNL103W MET4 SGTC_627 1391-0720 175 µM 0.31947002712123 0.355980416987802 no 1182 0.37468505820073 443 997839 SGTC_3104 9120930 49.47 µM 0.318727870717092 0.356310827502638 no 1183 0.374966439133741 420 17014836 SGTC_2275 7947463 200 µM 0.317935331407776 0.356663787792838 no 1184 0.375266995720624 402 1225414 SGTC_2938 9059746 27.26 µM 0.316562936884473 0.357275278963454 no 1185 0.375787631235853 407 6471769 SGTC_3219 9131112 49.47 µM 0.316122328090494 0.357471676727942 no 1186 0.375954829868425 386 17612988 YMR079W SEC14 SGTC_1564 D-Arginine 115 µM 0.313510520233907 0.358636642329334 no 1187 0.376946414643521 406 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_718 1130-0073 349 µM 0.313160355424646 0.358792929468341 no 1188 0.377079418196387 410 6740020 SGTC_1923 st058458 19.1 µM 0.312959151825053 0.358882742265635 no 1189 0.377155848219319 434 3534982 SGTC_939 1165-0479 45.3 µM 0.31250219494299 0.359086746596003 no 1190 0.377329447604108 426 1377347 SGTC_971 1315-0384 26.7 µM 0.31209096659962 0.359270370188043 no 1191 0.377485695765812 421 6769120 SGTC_3109 9122853 49.47 µM 0.310128019591154 0.360147321718202 no 1192 0.378231802721508 442 1234709 SGTC_2241 6772625 37.8075 µM 0.309832879744816 0.360279239991014 no 1193 0.378344023349156 417 2285411 SGTC_2298 7976326 193.81 µM 0.30878952257842 0.360745721252402 no 1194 0.378740819848832 398 2235818 SGTC_3266 9136860 49.47 µM 0.30841509991078 0.360913174862556 no 1195 0.378883246772945 420 4871271 YPR165W RHO1 SGTC_2148 5546263 113.568 µM 0.308057225959724 0.361073252289232 no 1196 0.379019394092064 394 792097 SGTC_1177 0983-0204 23.6 µM 0.307525269273162 0.361311242084003 no 1197 0.379221796088232 405 766818 SGTC_237 nikkomycin 200 µM 0.307286588731681 0.361418041788341 no 1198 0.379312621423853 416 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_968 1309-0633 340 µM 0.306322973672484 0.361849329546751 no 1199 0.379679374477616 422 3761976 SGTC_2745 rifampicin 24.3 µM 0.306274983585517 0.36187081319051 no 1200 0.379697642395544 429 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1239 0337-0584 35.4 µM 0.306025155194916 0.361982660487706 no 1201 0.379792746466572 415 914301 YML130C ERO1 SGTC_1979 st071809 45.3 µM 0.304070253690479 0.362858269390747 no 1202 0.380537184310154 434 4976333 SGTC_3252 9135871 49.47 µM 0.303871152614145 0.36294748796595 no 1203 0.380613028036281 419 17682838 SGTC_2349 9023730 187.07 µM 0.303031790278095 0.363323693794943 no 1204 0.380932817394086 400 4126287 SGTC_187 1488-2104 32.728 µM 0.302887170767418 0.363388526213377 no 1205 0.380987924323658 418 2852859 SGTC_2860 9025725 38.96 µM 0.302053875652532 0.363762165670533 no 1206 0.381305496490868 430 40546248 SGTC_1505 k297-0037 20.6 µM 0.301538560667965 0.363993291556352 no 1207 0.381501925150938 384 4089396 SGTC_2827 7993847 71.43 µM 0.30132624989445 0.364088530268389 no 1208 0.381582863021616 414 2985692 SGTC_2472 5377652 49.4 µM 0.30045070730079 0.364481371220168 no 1209 0.381916695164583 423 1610903 SGTC_1996 st072960 66.8 µM 0.299977810488289 0.364693611157975 no 1210 0.382097040648612 416 1719405 SGTC_1220 1838-0075 193 µM 0.299143038177153 0.365068364960073 no 1211 0.382415454584927 408 5529645 SGTC_1742 st038235 28.8875 µM 0.297739312264402 0.365698829235254 no 1212 0.382951068273616 461 564103 YBR002C RER2 SGTC_2557 derrustone 83.84 µM 0.297646096765169 0.365740708569968 no 1213 0.382986644051222 417 629853 An antioxidant. SGTC_429 1112-0049 25.5 µM 0.295762811268062 0.366587162594813 no 1214 0.383705612662646 373 2836170 SGTC_1051 3253-3903 78 µM 0.294372941612739 0.367212264571564 no 1215 0.384236470424037 436 5509239 SGTC_2839 9003951 25.97 µM 0.29341881907764 0.367641590690301 no 1216 0.384601021309292 430 2990634 SGTC_2519 cryptotanshinone 88.04 µM 0.293362268860008 0.367667041767135 no 1217 0.384622631208623 394 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1983 st071813 46.9 µM 0.29329303040632 0.367698204122124 no 1218 0.384649090233599 412 11838595 SGTC_3284 9108171 64.8615 µM 0.293288487435226 0.36770024882097 no 1219 0.384650826319255 430 8687505 SGTC_1021 4476-0760 85.3 µM 0.293205493717095 0.367737603264618 no 1220 0.384682542579395 405 746768 SGTC_3052 9092717 49.47 µM 0.29302985301902 0.36781666109063 no 1221 0.384749666662992 414 25237534 SGTC_2117 5521686 200 µM 0.292657931714873 0.367984085475601 no 1222 0.38489181412346 405 803312 SGTC_695 3505-6186 243 µM 0.292498111997998 0.36805603775084 no 1223 0.384952901602947 414 1819379 SGTC_1374 2889-5571 141 µM 0.292401527740562 0.368099523097269 no 1224 0.384989820139825 396 2853281 SGTC_2943 9068529 45.32 µM 0.292370619433148 0.36811343937071 no 1225 0.385001634805987 441 3270634 SGTC_1795 st049545 62.3 µM 0.292295345367374 0.368147331775263 no 1226 0.385030408680594 404 5291882 SGTC_186 3455-3465 67.277 µM 0.29201752765615 0.368272429027872 no 1227 0.385136611319372 431 755278 SGTC_1322 1348-1070 12 µM 0.291581451260725 0.368468816014978 no 1228 0.3853033295983 422 6758089 SGTC_638 3970-0837 4.09 µM 0.291092559681562 0.368689029176064 no 1229 0.385490265087107 396 4118451 YLR208W SEC13 SGTC_1608 st001473 40.5 µM 0.289291484137754 0.369500665575924 no 1230 0.386179164264149 452 7292267 SGTC_3038 9091290 49.47 µM 0.287286553580058 0.370404851526005 no 1231 0.386946458800548 447 25236843 SGTC_1725 st036284 20.55 µM 0.287155877137827 0.370463809065866 no 1232 0.386996484547613 408 707914 SGTC_1723 st034307 2.5525 µM 0.286756134232361 0.370644180720382 no 1233 0.387149526363456 408 867466 SGTC_929 2805-0021 398 µM 0.28536062302984 0.371274084777198 no 1234 0.387683936064306 421 3098024 SGTC_1402 3909-7673 35.9 µM 0.285334521722676 0.371285869643344 no 1235 0.387693933566131 416 5328014 SGTC_65 0798-0905 34.986 µM 0.285321304186396 0.37129183747079 no 1236 0.387698996265999 441 3602145 SGTC_2431 5490079 200 µM 0.284485336657892 0.371669346571377 no 1237 0.388019234839394 427 5722345 SGTC_459 nigericin 15.3 µM 0.283893799004141 0.371936549789483 no 1238 0.388245884377083 423 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_380 3970-0968 6 µM 0.282072676182141 0.372759555205263 no 1239 0.388943892058994 433 2891601 SGTC_2766 oltipraz 83.91 µM 0.281768087714483 0.372897262258031 no 1240 0.389060671086061 395 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_49 0717-0965 32.132 µM 0.279679636879928 0.37384190540776 no 1241 0.389861651262766 428 5889349 YGL099W LSG1 SGTC_3243 9134147 49.47 µM 0.279304952437994 0.374011462177721 no 1242 0.390005402986898 429 24282180 SGTC_946 3434-1334 87.4 µM 0.278775549343827 0.374251075669832 no 1243 0.390208539830767 409 4047976 SGTC_389 tpck 16.7 µM 0.277022849377347 0.375044712606487 no 1244 0.390881280609127 389 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_3283 9109332 35.8195 µM 0.275273792246743 0.375837227800999 no 1245 0.391552948857573 410 17027281 SGTC_2920 7982904 15.77 µM 0.275067919037369 0.375930545536877 no 1246 0.391632029051934 415 6456808 SGTC_636 0kpi-0074 126 µM 0.274694047609456 0.376100031670006 no 1247 0.391775652315579 417 616434 SGTC_801 0866-0028 10.1 µM 0.273630452250595 0.376582319109386 no 1248 0.39218431465918 405 6849771 SGTC_1991 st073000 8.92 µM 0.273101637804704 0.376822181855581 no 1249 0.392387543891488 431 4301969 YIL048W NEO1 SGTC_1072 oxiconazole 14.9 nM 0.272173176281185 0.377243433849627 no 1250 0.392744432886906 414 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2040 5100729 123 µM 0.271957784766583 0.377341179966884 no 1251 0.392827239590751 416 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1661 st013063 9.66 µM 0.270015592953621 0.378222913864571 no 1252 0.39357412878755 424 721395 SGTC_2580 diallyl disulphide 81.36 µM 0.269879249307833 0.378284836283112 no 1253 0.393626575841628 399 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_270 tamoxifen 5.46 µM 0.269442718473338 0.378483114031176 no 1254 0.393794508314164 443 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_842 0271-0008 11.1 µM 0.268360510519278 0.378974804265695 no 1255 0.394210916509299 423 1221709 SGTC_1803 st050068 52.4 µM 0.26832048991103 0.378992990985178 no 1256 0.394226317821017 433 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1844 rapamycin 4 nM 0.266415428399413 0.379859024649839 no 1257 0.394959642163386 414 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_16 erodoxin 22.806 µM 0.265287478958939 0.38037207058946 no 1258 0.395394004702336 433 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2106 5357045 167.29 µM 0.264996583001922 0.380504418317332 no 1259 0.395506047058791 425 668842 SGTC_413 propylparaben 100 µM 0.264338075479738 0.380804068405376 no 1260 0.395759711677753 405 7175 A pharmaceutical preservative. SGTC_117 lucigenin 22.078 µM 0.263598104785708 0.381140873165632 no 1261 0.396044809526995 436 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1307 1187-1599 12.2 µM 0.26315984068127 0.381340395758882 no 1262 0.39621369130379 421 1538471 SGTC_148 3253-0744 288.01 µM 0.262831044960038 0.381490102867614 no 1263 0.396340403052417 405 6893655 SGTC_1974 st069448 26.9 µM 0.262034669759857 0.381852781485172 no 1264 0.396647356583531 435 6323587 YNR016C ACC1 SGTC_622 1348-1566 26.3 µM 0.261662241758526 0.382022425185565 no 1265 0.396790926607579 431 7340407 SGTC_1962 st076595 64.5 µM 0.261424147417493 0.3821308907865 no 1266 0.396882718688488 414 279619 SGTC_1073 triclabendazole 3.09 µM 0.260320258368474 0.38263389618612 no 1267 0.397308373616154 404 50248 An antihelmetic and likely tubulin inhibitor. SGTC_463 ikarugamyin 104 µM 0.25868575100092 0.383379050168963 no 1268 0.3979388572464 443 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_3337 9144342 33.5465 µM 0.258392048172244 0.383512991892976 no 1269 0.398052176461833 407 17682949 SGTC_1010 4112-3296 15.2 µM 0.256885987734532 0.384200041726697 no 1270 0.39863339392943 422 704384 SGTC_1497 4476-2978 41.3 µM 0.256535608815813 0.384359933388393 no 1271 0.398768644135159 451 1528379 SGTC_1862 st057513 3.81 µM 0.255879887428757 0.384659217665201 no 1272 0.399021792623963 423 5393163 SGTC_2139 5578692 56.4705 µM 0.255167568663652 0.384984412016317 no 1273 0.399296839288984 424 650991 YMR113W FOL3 SGTC_790 1575-0012 79.1 µM 0.254632396650417 0.385228786941378 no 1274 0.399503517422036 460 378741 YLR208W SEC13 SGTC_3060 1327-0027 12.5 µM 0.254292739226999 0.385383907936922 no 1275 0.399634704370651 432 16000455 YPR107C YTH1 SGTC_2789 5281112 71.43 µM 0.252705356436232 0.386109105830483 no 1276 0.400247954184984 423 765948 SGTC_1843 st055809 45.5 µM 0.25116654630944 0.386812493325428 no 1277 0.400842673922041 408 16413835 SGTC_332 4112-0506 40.9 µM 0.250767206416969 0.386995091792181 no 1278 0.400997048533288 449 2790355 SGTC_442 cape 100 µM 0.248603182474804 0.387985027433878 no 1279 0.401833873257842 442 5281787 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.248276632544072 0.388134471540882 no 1280 0.401960188806793 411 688664 SGTC_3097 9117246 49.47 µM 0.247572527295851 0.3884567584842 no 1281 0.40223258456277 404 16423892 SGTC_3308 9128332 17.569 µM 0.247549023104919 0.388467518278306 no 1282 0.402241678400767 447 17332805 YDL196W YDL196W SGTC_3027 9089541 49.47 µM 0.246224864907503 0.389073831983157 no 1283 0.402754084273119 430 9943819 SGTC_619 1652-1634 108 µM 0.245302577425474 0.389496294398532 no 1284 0.403111078106349 439 5400454 SGTC_80 0159-0065 512.242 µM 0.245277901279889 0.389507599334401 no 1285 0.403120630720281 438 1548079 SGTC_245 methotrexate 289.6 µM 0.244659400390205 0.389790985001596 no 1286 0.403360083266932 448 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_3142 9086498 49.47 µM 0.243811189537145 0.390179714782107 no 1287 0.403688526905566 451 25236367 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.243513005985653 0.390316396570097 no 1288 0.403804005489913 406 3256 An antibiotic and ribosome inhibitor. SGTC_596 1155-0152 116 µM 0.243441623144675 0.390349119147308 no 1289 0.403831651416132 445 280313 SGTC_3176 9106582 49.47 µM 0.241450566107669 0.39126215095763 no 1290 0.404602962835356 427 17018027 SGTC_3144 9087057 49.47 µM 0.241441450764095 0.391266332330116 no 1291 0.404606494864309 472 17249618 SGTC_3004 9076122 71.4286 µM 0.24114049240282 0.391404394412067 no 1292 0.404723115089562 455 44782551 SGTC_1443 4112-3303 14 µM 0.240937325396126 0.391497603280799 no 1293 0.404801846321229 445 704433 SGTC_3347 9188721 44.724 µM 0.240843733250032 0.391540543540219 no 1294 0.404838116424972 456 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1257 0669-0121 16 µM 0.240642287292215 0.391632971822137 no 1295 0.404916186280743 428 4307855 SGTC_1472 k841-0093 193 µM 0.2402822367081 0.391798186981803 no 1296 0.405055732371306 438 X1472 SGTC_50 0929-0078 56.389 µM 0.239042572190173 0.392367176620477 no 1297 0.405536285813524 446 1377751 SGTC_1346 1488-2224 62.4 µM 0.238950451454291 0.39240946802399 no 1298 0.40557200192409 435 3722427 SGTC_791 1348-1292 225 µM 0.237970923897244 0.392859234579202 no 1299 0.405951822909268 442 5437054 SGTC_8 0354-0001 70 µM 0.237625964748331 0.393017662474691 no 1300 0.406085605150562 443 4993152 SGTC_1200 1643-0193 18.4 µM 0.237565735791348 0.393045325385055 no 1301 0.406108964301776 453 5403974 SGTC_1103 duloxetine 36.1 µM 0.237564686367796 0.393045807385731 no 1302 0.406109371312342 433 60835 A selective serotonin reuptake inhibitor. SGTC_705 1124-0212 310 µM 0.237127604048404 0.393246573725821 no 1303 0.406278899025721 472 9554485 SGTC_1105 epirubicin 18.1 µM 0.237080238261613 0.393268332101643 no 1304 0.406297271480175 428 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3071 9117417 49.47 µM 0.234524542848494 0.39444283203154 no 1305 0.407288890984021 453 45595590 YGL055W OLE1 SGTC_3064 1327-0027 10 µM 0.234466981023652 0.394469296343657 no 1306 0.407311232059196 458 16000455 YPR107C YTH1 SGTC_1405 3909-7894 12 µM 0.233854355373929 0.394750983942462 no 1307 0.407549024906821 447 7104060 SGTC_1157 4092-0394 27.6 µM 0.233579742966015 0.394877269641742 no 1308 0.407655627763769 407 3659885 SGTC_984 1492-0255 2.91 µM 0.231996890724662 0.395605389045416 no 1309 0.408270214385767 458 1585198 SGTC_1028 k015-0029 4.8 µM 0.231722621513144 0.3957315912838 no 1310 0.408376730058741 436 4588309 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.231714552408652 0.395735304367254 no 1311 0.408379863892892 406 2724 A muscle relaxant with antifungal properties. SGTC_708 3448-5400 146 µM 0.229600747969269 0.396708318708895 no 1312 0.40920101280299 456 3462195 SGTC_1767 st044992 70.3 µM 0.228886987931534 0.397037018273981 no 1313 0.409478377128192 471 9600693 SGTC_2815 7968870 71.43 µM 0.228272142547702 0.397320224490896 no 1314 0.409717339947203 442 2977326 YHR190W ERG9 SGTC_3201 9113999 49.47 µM 0.227100002815277 0.397860278007338 no 1315 0.410172990929757 426 16649224 SGTC_2336 9001819 198.65 µM 0.22619448784665 0.398277620510048 no 1316 0.410525078792829 469 2989602 SGTC_450 aminopyrene 156 nM 0.226046346612814 0.398345908366213 no 1317 0.41058268684461 457 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2910 7948405 25.97 µM 0.22587854653461 0.398423262012796 no 1318 0.410647942010392 461 2971328 SGTC_2840 9008771 71.43 µM 0.223966326332338 0.399305051777887 no 1319 0.411391752680265 442 2992978 SGTC_1312 1218-2183 165 µM 0.223191663823063 0.399662421551447 no 1320 0.411693169811102 451 6744073 SGTC_775 4577-0580 57.3 µM 0.223054614046315 0.399725654551633 no 1321 0.411746500593333 447 2006902 SGTC_3181 9108277 49.47 µM 0.222840372542795 0.399824508087811 no 1322 0.411829872597573 459 17097298 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.221586700235959 0.400403095676406 no 1323 0.412317818403079 454 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2810 7959871 45.46 µM 0.221462648814613 0.400460359078295 no 1324 0.412366108236165 422 2974535 SGTC_421 streptovitacin 30 mM 0.22100644862832 0.40067096413262 no 1325 0.412543705924437 427 91467 include heat shock SGTC_3152 9099253 49.47 µM 0.220633131922922 0.400843327471828 no 1326 0.412689050587267 452 25236131 SGTC_2565 isoliquiritigenin 100 µM 0.220616927462559 0.400850809639525 no 1327 0.412695359796193 416 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1291 0993-0025 5.79 µM 0.219111849525868 0.401545915136745 no 1328 0.413281460229816 449 4353356 SGTC_902 1120-0002 2.07 µM 0.218967814604669 0.401612452627451 no 1329 0.413337559792683 433 3280475 SGTC_2583 asiatic acid 100 µM 0.2180428282311 0.402039821572773 no 1330 0.413697871010249 491 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_3074 9116018 49.47 µM 0.217624220425152 0.402233268337327 no 1331 0.413860955791387 458 17027303 SGTC_2340 7987427 183.45 µM 0.216358925959649 0.402818130791685 no 1332 0.414353990160056 436 2239331 SGTC_3045 9092950 49.47 µM 0.216144267543516 0.402917374884716 no 1333 0.414437647326116 437 44120432 SGTC_2978 9011784 42.97 µM 0.215966519280045 0.402999558857809 no 1334 0.414506922721498 434 2994934 SGTC_1791 st048313 56.1 µM 0.215949444079799 0.403007454000537 no 1335 0.414513577729637 451 1204976 SGTC_277 nystatin 15.5 µM 0.215365072806894 0.403277676379577 no 1336 0.414741349460901 458 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1188 1403-0014 4.57 µM 0.214483829110239 0.403685264504426 no 1337 0.415084888026378 447 9614867 SGTC_2868 9035608 32.47 µM 0.214380926548365 0.40373286527714 no 1338 0.415125007160606 463 6462614 SGTC_2795 7780010 54.55 µM 0.214376801509555 0.403734773471556 no 1339 0.415126615428482 427 953673 SGTC_3091 9116372 49.47 µM 0.21437500261384 0.403735605620265 no 1340 0.415127316781405 421 17169793 SGTC_2297 7971671 152.32 µM 0.214310962732243 0.403765230025357 no 1341 0.415152284807466 445 909016 SGTC_1319 1306-0155 43.7 µM 0.213996723776644 0.40391060278447 no 1342 0.415274806026326 444 3122360 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.213977970029372 0.403919279035089 no 1343 0.415282118340216 459 551469 SGTC_2961 9083290 32.55 µM 0.213957681013734 0.403928665616889 no 1344 0.41529002930694 463 17741490 SGTC_1179 1021-1431 9.29 µM 0.213872932781718 0.403967874436152 no 1345 0.415323074181475 467 2840958 SGTC_1630 st005209 31.3 µM 0.213428137867656 0.40417367487642 no 1346 0.415496517611061 463 3367314 SGTC_2952 9073731 13.78 µM 0.212199660985663 0.404742211720806 no 1347 0.415975635605766 411 16457353 SGTC_1569 carminic acid 40.6 µM 0.211817724141419 0.404919012439545 no 1348 0.416124620196672 472 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2467 5474540 200 µM 0.211804522267461 0.404925124008703 no 1349 0.416129770153217 416 5413519 SGTC_3185 9108267 49.47 µM 0.211217634239702 0.405196836632424 no 1350 0.416358725509362 447 4910486 SGTC_2679 rapamycin 1 nM 0.210949563870511 0.405320960874587 no 1351 0.416463313929429 441 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2441 5730946 39.09 µM 0.21026624286167 0.405637401079045 no 1352 0.416729940309055 422 1774275 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.210187735882034 0.405673760954168 no 1353 0.416760575559045 446 2724278 An inhibitor of dopamine biosynthesis. SGTC_2070 5230947 200 µM 0.210119740458291 0.405705253144572 no 1354 0.416787109363896 466 2835538 SGTC_3012 9080433 71.4286 µM 0.209094029993099 0.406180386535999 no 1355 0.417187417539689 468 17688859 SGTC_3108 9121785 49.47 µM 0.208746386715882 0.406341454532356 no 1356 0.41732311319152 465 17140271 SGTC_2267 7931562 200 µM 0.2084807660729 0.406464530977339 no 1357 0.417426799573833 421 934880 SGTC_1798 st045719 60.953 µM 0.206803604403592 0.40724186382503 no 1358 0.4180816205485 476 3980186 SGTC_1597 7-benzyloxygramine 47.5 µM 0.206136201405013 0.407551294369598 no 1359 0.418342260666571 464 260807 SGTC_1638 st008370 60.6 µM 0.205190429785549 0.407989884755633 no 1360 0.418711673147513 430 24207134 SGTC_1208 2323-2347 50.3 µM 0.202819913204291 0.409089689338108 no 1361 0.419637896460732 470 5412760 SGTC_363 0455-0021 3.06 µM 0.20209064337791 0.409428179557595 no 1362 0.419922931230333 459 4597466 SGTC_780 0109-0199 192 µM 0.201947032736217 0.409494844330677 no 1363 0.419979066337941 467 610414 SGTC_181 1447-1644 8.07 µM 0.201877027142809 0.409527342223722 no 1364 0.420006430997325 457 534600 SGTC_1233 0325-0408 14.2 µM 0.20120353906778 0.409840019589253 no 1365 0.420269712153362 467 12874 SGTC_2669 eugenol 100 µM 0.200906541308145 0.409977923672742 no 1366 0.420385826388726 461 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1337 1486-1011 40.3 µM 0.200083422209419 0.410360178252893 no 1367 0.420707669187562 442 X1337 SGTC_41 0478-0632 82.643 µM 0.199373371772164 0.41068999245724 no 1368 0.420985344290632 477 3750424 SGTC_2324 6149169 200 µM 0.199309490111706 0.410719668208705 no 1369 0.421010328032299 477 2888231 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.198136084895951 0.411264855639297 no 1370 0.421469296394505 452 6708760 SGTC_1861 st057647 17.4 µM 0.197679148508927 0.411477203813236 no 1371 0.421648052427206 492 688668 SGTC_2596 sinensetin 100 µM 0.197624487668675 0.411502607620101 no 1372 0.421669437131178 435 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1142 3253-1408 9.78 µM 0.196537984794739 0.412007640282469 no 1373 0.422094552401955 462 256655 SGTC_2611 pyromycin 23.93 µM 0.196388425539022 0.412077170453624 no 1374 0.422153077473979 435 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_752 1896-0090 130 µM 0.195652677192032 0.412419260367939 no 1375 0.42244101327934 451 772567 SGTC_3086 9117350 49.47 µM 0.195303989655423 0.412581407658803 no 1376 0.422577486960374 458 2679265 SGTC_851 0394-0702 453 µM 0.195164660748009 0.412646202805504 no 1377 0.422632021847277 449 762646 SGTC_1011 4112-3381 17.4 µM 0.193952061306702 0.413210224576537 no 1378 0.423106709285583 457 2877139 SGTC_2867 9039098 71.43 µM 0.188936096437879 0.415545213665764 no 1379 0.425071451088545 457 6463460 SGTC_3186 9110464 49.47 µM 0.188269088469377 0.415855940193874 no 1380 0.425332857929841 460 17018021 SGTC_898 1000-0849 28.3 µM 0.187508652869708 0.416210254278704 no 1381 0.425630920000685 473 6751807 SGTC_2449 5812982 45.77 µM 0.187379997214384 0.416270206283767 no 1382 0.425681352372933 466 776185 SGTC_1457 k015-0032 57.3 µM 0.186211509633835 0.416814796625651 no 1383 0.426139449216465 443 4302660 SGTC_2466 5983409 37.09 µM 0.182462253359733 0.418563264246004 no 1384 0.427609987262391 467 2879657 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.182105517288577 0.418729712731994 no 1385 0.42774995948124 453 390807 SGTC_944 3370-0224 231 µM 0.182000666907967 0.418778637346055 no 1386 0.427791101262861 441 4580514 SGTC_1910 st062352 60.4 µM 0.181950588757141 0.418802004935868 no 1387 0.427810751486194 451 2245730 SGTC_1023 4482-3888 16 µM 0.18162340458068 0.418954683467282 no 1388 0.427939140066583 470 3303168 SGTC_746 1095-0025 46.6 µM 0.18127610658442 0.419116761347067 no 1389 0.428075429749961 485 6749286 SGTC_95 0471-0001 561.058 µM 0.181097498519103 0.419200119943375 no 1390 0.428145524013824 435 4015405 SGTC_2630 antimycin a 100 µM 0.180665281898358 0.419401855794794 no 1391 0.428315155663581 449 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_61 0978-8327 98.565 µM 0.178975166080104 0.420190915376748 no 1392 0.42897860071376 455 6150059 YHR072W ERG7 SGTC_769 0302-0231 76 µM 0.178875860718924 0.420237287800696 no 1393 0.429017588711794 470 571869 YER009W NTF2 SGTC_1108 betulinic acid 729.144 nM 0.178850661814059 0.420249055058558 no 1394 0.42902748209301 429 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_806 3966-4455 5.86 µM 0.178069904187475 0.420613684597894 no 1395 0.429334038621395 455 714982 SGTC_731 3966-0296 387 µM 0.177278762184437 0.420983233341371 no 1396 0.429644715946061 458 660956 SGTC_1480 1070-0044 41.2 µM 0.176347480297426 0.421418331748589 no 1397 0.430010481294043 451 3124987 SGTC_1439 4092-1168 46 µM 0.1755973971269 0.421768843236024 no 1398 0.430305123685576 482 2886240 SGTC_844 0330-0132 15.3 µM 0.175446874606786 0.42183918940904 no 1399 0.430364255563235 487 2828079 SGTC_785 1270-0111 65.3 µM 0.175157337741324 0.421974510460886 no 1400 0.430478002790284 455 6741994 SGTC_1690 st023502 41.2 µM 0.174860469973663 0.422113267327167 no 1401 0.430594636019492 483 24207482 SGTC_2008 4012253 172 µM 0.174847493499618 0.422119332789905 no 1402 0.43059973434696 460 603940 SGTC_2932 9016711 44.54 µM 0.172757829857476 0.423096323265541 no 1403 0.431420892727818 454 7117328 SGTC_2190 6049624 200 µM 0.17264134927407 0.423150795968501 no 1404 0.431466673925927 477 2265554 SGTC_3026 9090633 49.47 µM 0.172569215422771 0.423184530446373 no 1405 0.431495025671876 447 25236842 SGTC_579 4491-1009 110 µM 0.172139495555374 0.423385507052509 no 1406 0.431663931608614 495 1271041 SGTC_129 0088-0017 176.636 µM 0.17205822906309 0.423423516995633 no 1407 0.431695875668354 479 182446 SGTC_103 0844-0104 51.839 µM 0.167551451730683 0.425532531548712 no 1408 0.433468083515698 450 5375804 SGTC_93 0109-0045 59.227 µM 0.167469537849868 0.425570884300375 no 1409 0.433500307146041 475 88733 SGTC_465 cgp-37157 41 µM 0.167257339633271 0.425670240522148 no 1410 0.433583784637025 471 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2665 lovastatin 100 µM 0.167162043200202 0.425714862101202 no 1411 0.433621274639902 453 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2385 9074692 200 µM 0.167152643320803 0.425719263550042 no 1412 0.433624972622908 436 17046906 SGTC_3124 9127567 49.47 µM 0.166854540998207 0.425858853343584 no 1413 0.433742251323118 464 17592030 SGTC_2330 7979373 200 µM 0.165305954169127 0.426584145810198 no 1414 0.434351586272912 447 1863007 SGTC_2487 5918373 44.05 µM 0.165251014404818 0.42660988184411 no 1415 0.434373206738968 505 2876279 SGTC_2299 7976368 114.88 µM 0.163560664738396 0.427401862987375 no 1416 0.435038506295807 449 2979718 SGTC_1519 esterone 74 µM 0.163481082865086 0.427439156796853 no 1417 0.435069833230885 447 698 A steroid. SGTC_857 0438-0306 1.35 µM 0.163150004709461 0.427594314230656 no 1418 0.435200164566854 434 4686136 SGTC_3224 9130643 49.47 µM 0.162181474108924 0.428048273452213 no 1419 0.435581474087517 439 17644395 SGTC_2232 chlorophetanol 41.5365 µM 0.161357716845641 0.428434451056012 no 1420 0.435905833643563 478 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2796 7949634 45.45 µM 0.160842175628767 0.428676171796547 no 1421 0.436108853160114 458 2971588 SGTC_3087 9117406 49.47 µM 0.160472860928621 0.428849348068255 no 1422 0.436254299201561 426 42546093 SGTC_2841 9004761 38.96 µM 0.159344995975059 0.429378302678867 no 1423 0.436698535971231 435 2991039 SGTC_962 1254-0300 21.5 µM 0.158438356595359 0.429803597250111 no 1424 0.437055695637149 472 7340576 SGTC_1086 cerivastatin 2.18 µM 0.158124598684909 0.429950796639121 no 1425 0.437179308752721 468 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2807 7945238 51.95 µM 0.157972384926046 0.430022211167776 no 1426 0.437239279544751 483 17148797 SGTC_3157 9099274 49.47 µM 0.157703280473019 0.430148473210359 no 1427 0.437345307700444 491 17217662 SGTC_2518 prenyletin 46.28 µM 0.156844068622771 0.430551657520874 no 1428 0.437683870449244 483 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2358 9037157 4 µM 0.156664389599583 0.430635980892688 no 1429 0.437754676720645 483 2388925 SGTC_1065 prochlorperazine maleate 2.48 µM 0.156249410407815 0.430830742722893 no 1430 0.437918215551165 499 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2770 toltrazuril 17.5 µM 0.156041665553669 0.430928249760339 no 1431 0.438000089545791 474 68591 Kills coccidiodes. SGTC_1398 3558-0053 112 µM 0.155885754685967 0.431001430785738 no 1432 0.438061537073918 467 4532369 SGTC_2030 5175110 200 µM 0.155768952688411 0.431056256546775 no 1433 0.43810757200855 486 2831986 SGTC_2687 chenodiol 100 µM 0.154648136378849 0.431582424590881 no 1434 0.438549359561103 464 5702181 A cholesterol synthesis inhibitor. SGTC_362 0310-0100 9.03 µM 0.154546986193538 0.431629915607088 no 1435 0.438589233289029 454 790235 SGTC_890 0929-0006 47.2 µM 0.154540480727712 0.43163297002171 no 1436 0.438591797785891 460 1378169 SGTC_466 geldanamycin 89.2 µM 0.154223927929473 0.43178160128453 no 1437 0.438716588066973 480 5288382 HSP90 inhibitor. SGTC_1786 berberine 21.6 µM 0.154202088361582 0.431791855988908 no 1438 0.43872519780599 488 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2771 fluoxetine 41.05 µM 0.154110687266386 0.431834773600903 no 1439 0.438761230865304 495 3386 A selective serotonin reuptake inhibitor. SGTC_1436 4092-1007 8.32 µM 0.152129556711396 0.432765215261354 no 1440 0.43954237631626 461 2881121 SGTC_2746 daunorubicin 9.88 µM 0.151635815653152 0.432997159919982 no 1441 0.439737091615508 478 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2508 celastrol 40.54 µM 0.150507419200927 0.43352733308188 no 1442 0.440182148868902 462 122724 Celastrol is a natural product and antioxidant. SGTC_2219 9098279 200 µM 0.149376322416422 0.434058895051779 no 1443 0.440628347038195 476 902349 SGTC_3336 9143619 71.43 µM 0.148526842158506 0.434458189052318 no 1444 0.440963501951144 498 45595730 SGTC_1591 genipin 88.4 µM 0.148185016038574 0.434618881622774 no 1445 0.441098378365198 488 442424 A DNA cross-linking agent. SGTC_840 0245-0196 390 µM 0.147941182524512 0.434733514439544 no 1446 0.441194593415807 457 3827528 SGTC_2178 5812956 200 µM 0.147939139129973 0.434734475118509 no 1447 0.441195399740104 493 5403383 SGTC_977 1348-1378 135 µM 0.146876009967864 0.435234345461172 no 1448 0.441614943905887 499 X977 SGTC_1155 4088-0394 48.2 µM 0.146564938989959 0.435380626845654 no 1449 0.441737714696376 467 2326248 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.145784815218512 0.435747519548223 no 1450 0.442045631763172 498 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_926 2268-1401 59.4 µM 0.14570828469259 0.435783514886929 no 1451 0.442075840468268 502 2931578 SGTC_1360 1598-0022 39.8 µM 0.144568790342076 0.436319526997748 no 1452 0.442525670006515 484 761525 SGTC_1961 st076550 68.7 µM 0.144035077035787 0.436570623193578 no 1453 0.442736385477839 455 1579337 SGTC_2638 epoxomicin 18 µM 0.143797038829883 0.436682621319677 no 1454 0.44283037062289 481 9915668 A protesome inhibitor. SGTC_3009 9080819 71.4286 µM 0.143551851140425 0.436797988618906 no 1455 0.442927181977583 463 17027216 SGTC_2560 caryophyllene 100 µM 0.142715369125215 0.43719161594706 no 1456 0.443257489082682 470 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2651 TUB2.036 5 µM 0.142375097411282 0.437351757043281 no 1457 0.443391865688271 461 15992207 YFL037W TUB2 SGTC_663 1486-0733 13.9 µM 0.140882915569032 0.438054139136978 no 1458 0.443981219463064 465 722445 YPR165W RHO1 SGTC_40 0327-0103 19.753 µM 0.140331839593173 0.438313584541177 no 1459 0.44419890443264 465 409036 SGTC_2832 7992762 51.95 µM 0.139524211637196 0.438693861947551 no 1460 0.444517962468212 452 2985177 SGTC_2163 5671233 125 µM 0.138328084374061 0.439257170926768 no 1461 0.444990565371135 483 701023 SGTC_1915 st067105 30.6 µM 0.136913151300736 0.439923683957092 no 1462 0.445549721748395 496 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2495 cafestol 54.53 µM 0.136032340105283 0.440338681676988 no 1463 0.445897857441256 474 16667697 An anti-infammatory. SGTC_2724 maprotiline 69.64 µM 0.134812446754045 0.440913547470857 no 1464 0.446380082296773 493 4011 A tricyclic antidepressant. SGTC_1183 1254-0324 198 µM 0.13431185507558 0.441149483732622 no 1465 0.446577989594162 462 5799357 SGTC_2661 dactinomycin 12.96 µM 0.133358442560967 0.44159889885936 no 1466 0.446954954907085 487 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2221 6807166 181.081 µM 0.132903219182283 0.44181350648357 no 1467 0.447134960476191 476 674925 SGTC_2278 7948257 134.34 µM 0.130687391727751 0.442858364921096 no 1468 0.448011303370194 490 1247028 SGTC_2888 9058547 12.99 µM 0.130469407246909 0.442961175622374 no 1469 0.448097528354525 465 16476514 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.128673023793664 0.443808571650164 no 1470 0.448808190912228 486 688803 SGTC_83 0170-0301 39.027 µM 0.128429415235625 0.443923507370281 no 1471 0.448904576956587 474 3089716 SGTC_2541 muurolladie-3-one 83.07 µM 0.127550756797272 0.444338101877015 no 1472 0.449252251543235 489 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_3255 9139072 49.47 µM 0.126623627641635 0.444775633304001 no 1473 0.449619147656066 480 17646060 SGTC_288 1315-0019 35.1 µM 0.124727979750289 0.445670437646693 no 1474 0.450369452865654 502 6811474 SGTC_304 1310-0298 97 µM 0.124671972275057 0.445696879136967 no 1475 0.450391623565553 504 1550234 SGTC_2277 7947813 106.88 µM 0.123515115956932 0.446243092314594 no 1476 0.450849602570654 494 1246798 SGTC_3047 9092122 49.47 µM 0.122170683490973 0.446877998243291 no 1477 0.451381921844536 480 17173831 SGTC_1977 st070720 65.3 µM 0.121690466154873 0.44710481315052 no 1478 0.451572082013152 466 682188 SGTC_1435 4092-0789 56.7 µM 0.121346124735952 0.447267462180492 no 1479 0.451708443830656 501 2248285 SGTC_2036 5160441 105 µM 0.121184005703626 0.447344041876834 no 1480 0.451772646172706 477 134534 YIL048W NEO1 SGTC_917 harmaline 728.087 nM 0.120056070962081 0.44787689532041 no 1481 0.452219365455607 471 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1384 3089-0840 101 µM 0.119957484442371 0.44792347356881 no 1482 0.452258413593438 473 1069836 SGTC_2378 9074213 121.43 µM 0.119802219587099 0.447996831554562 no 1483 0.452319911816354 499 657714 SGTC_1851 st056236 18.9 µM 0.119121344892568 0.448318545387168 no 1484 0.452589610183585 486 5393171 SGTC_75 0159-0059 199.013 µM 0.118608934163163 0.448560682291452 no 1485 0.452792593441969 508 5377270 SGTC_1794 st048918 76.9 µM 0.117919484962524 0.448886507985071 no 1486 0.453065727097069 492 672303 SGTC_722 3534-0461 190 µM 0.116471226002886 0.449571050379362 no 1487 0.453639544597012 468 658262 SGTC_632 0781-2353 4.65 µM 0.11567441467021 0.449947739940325 no 1488 0.453955292121087 495 6811515 YHR007C ERG11 SGTC_1026 k007-1105 30.6 µM 0.115235444571829 0.450155280693075 no 1489 0.454129252547026 470 7066794 SGTC_2080 5212524 12.4 µM 0.115066281029482 0.450235263197141 no 1490 0.454196293090189 494 260183 SGTC_2488 5268135 45.7 µM 0.114773876237295 0.450373520372275 no 1491 0.454312177968264 485 1270356 YLR208W SEC13 SGTC_2919 7978188 46.38 µM 0.113593336295128 0.450931773792605 no 1492 0.454780085012341 494 2980291 SGTC_1928 4'-methoxychalcone 40.3 µM 0.112812174547162 0.451301222794907 no 1493 0.455089733035065 496 641818 SGTC_1340 1486-1359 257 µM 0.112435250680856 0.451479503348573 no 1494 0.455239153259046 488 4309068 SGTC_3278 9139605 49.47 µM 0.112382222094938 0.451504586031862 no 1495 0.455260175368809 480 7958859 SGTC_462 ag-879 158 µM 0.111439311972747 0.451950617638585 no 1496 0.455633993869708 508 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2286 7945697 125 µM 0.111376294223029 0.451980429549899 no 1497 0.455658978779783 477 1245733 SGTC_3030 9087619 49.47 µM 0.110004471646969 0.452629466747149 no 1498 0.456202914289269 513 25236973 SGTC_887 0885-0007 9.62 µM 0.109661592513924 0.452791709689663 no 1499 0.456338880692174 502 5719458 SGTC_2816 7982706 58.44 µM 0.108985451527006 0.453111667957745 no 1500 0.456607014797019 488 2981853 SGTC_1609 st001574 46.4 µM 0.108903061154481 0.453150658184819 no 1501 0.456639689319095 515 3960012 SGTC_176 1486-1328 72.834 µM 0.107837661305101 0.453654886064767 no 1502 0.457062233835521 474 22310231 SGTC_2648 atorvastatin 78.68 µM 0.106825787788405 0.454133850425224 no 1503 0.457463594418872 506 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2067 5224629 34.075 µM 0.104642524630822 0.455167511500246 no 1504 0.458329735072009 473 2835000 SGTC_201 4262-0159 12.803 µM 0.104635282466733 0.455170940795768 no 1505 0.458332608503295 504 1341029 SGTC_1184 1269-1718 139 µM 0.104305158249524 0.455327264118921 no 1506 0.458463592276682 487 5403821 SGTC_1830 st055982 50.3 µM 0.104283240665407 0.455337642971277 no 1507 0.458472288702094 498 455313 An antimicrobial agent. SGTC_677 0929-0063 136 µM 0.104086957415225 0.455430592295821 no 1508 0.458550170554669 502 1539583 SGTC_2405 ticlatone 3.52 µM 0.103317430237077 0.455795022990218 no 1509 0.458855521159904 416 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2068 5226020 147 µM 0.102763066730171 0.456057580095796 no 1510 0.459075509254397 487 1810509 SGTC_5 0352-0601 109.883 µM 0.102448208786714 0.456206711361054 no 1511 0.459200459930495 475 762456 SGTC_1945 st075991 56.6 µM 0.102144538424897 0.456350549515634 no 1512 0.459320974658061 438 1084980 SGTC_2928 9011484 9.79 µM 0.102083838445329 0.456379301684531 no 1513 0.459345064522139 503 2994751 SGTC_44 0929-0055 61.211 µM 0.101284218297933 0.456758084420667 no 1514 0.459662421869834 508 1379590 SGTC_646 4092-0839 27.3 µM 0.101256117978878 0.456771396352409 no 1515 0.459673574937352 507 877796 SGTC_410 α-linolenic acid 100 µM 0.10055446752872 0.457103804101248 no 1516 0.459952071537957 512 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2256 7954252 200 µM 0.100329976984796 0.45721016311669 no 1517 0.460041179681706 490 2972920 SGTC_541 4513-1321 94 µM 0.0997897739409426 0.4574661127864 no 1518 0.460255613369217 476 747515 SGTC_592 k241-0073 46.5 µM 0.0997705679619944 0.457475212956797 no 1519 0.4602632373989 507 4230158 SGTC_1144 3486-0183 12.5 µM 0.0993512619826908 0.457673893921664 no 1520 0.460429689266796 511 6744069 SGTC_2880 9042983 58.44 µM 0.099216373142449 0.457737810942071 no 1521 0.460483237556681 491 6464714 SGTC_2104 5389443 200 µM 0.0989007709616147 0.457887363170791 no 1522 0.460608528384995 489 2244536 SGTC_160 3453-0671 289.699 µM 0.0982084756685672 0.458215437222074 no 1523 0.46088337619568 488 5322268 SGTC_378 3970-0959 8.33 µM 0.0977609469207348 0.458427533228932 no 1524 0.461061059314656 506 6615653 SGTC_2911 7942208 15.64 µM 0.0964227897365529 0.459061792571586 no 1525 0.461592396429775 492 1243384 SGTC_1420 4'-methoxyflavone 42 µM 0.0948228770434787 0.459820255375252 no 1526 0.462227757745295 506 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1612 st002233 45.4 µM 0.0941013895985593 0.460162335417583 no 1527 0.462514308270739 503 1035021 SGTC_1274 0865-0114 173 µM 0.0938325830385099 0.460289792672604 no 1528 0.46262107416996 492 870624 SGTC_3286 9117135 37.221 µM 0.0933954103055345 0.460497091101021 no 1529 0.462794718313971 514 3438150 SGTC_3348 9149464 3.537 µM 0.0921809431209074 0.461073022935372 no 1530 0.463277139378913 498 1951442 SGTC_1451 4152-0210 104 µM 0.0913664557732115 0.46145931977814 no 1531 0.463600707325441 514 659563 SGTC_1950 st077106 7.18 µM 0.0908996353895172 0.461680740789628 no 1532 0.463786169955792 460 13831864 SGTC_3259 9138485 49.47 µM 0.0905239536554342 0.46185894178654 no 1533 0.463935429915114 457 17646153 SGTC_2379 9035213 200 µM 0.0903869898108987 0.461923911168 no 1534 0.463989847499953 515 646551 SGTC_2719 novobiocin 32.65 µM 0.089632548219932 0.462281801907145 no 1535 0.464289609379607 488 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1990 st072050 59.8 µM 0.0884648101746174 0.46283581164026 no 1536 0.464753626031257 521 17233948 SGTC_1680 diphenhydramine 100 µM 0.0882786103455973 0.462924157081083 no 1537 0.464827619522441 512 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1895 st058434 18.3 µM 0.0882395099760817 0.462942709099561 no 1538 0.464843157676529 502 5393175 SGTC_110 0850-0284 111.64 µM 0.0881211768104423 0.462998855327785 no 1539 0.464890182596033 502 3906265 SGTC_2122 5258151 111.688 µM 0.0881003999673549 0.463008713513977 no 1540 0.464898439244616 480 2173356 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.0878865629488636 0.463110176115384 no 1541 0.46498341824465 513 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1559 coumarin 343 70.1 µM 0.086410129225937 0.463810787898553 no 1542 0.465570197545934 495 108770 A hepatotoxic, DNA x-linker. SGTC_1888 azatryptophan 97.5 µM 0.0856975496868093 0.464148968410559 no 1543 0.465853425015431 463 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2174 5790901 200 µM 0.0856066249043378 0.464192121938436 no 1544 0.465889565942063 523 786020 SGTC_2857 9024691 58.44 µM 0.0852862330497837 0.464344185472824 no 1545 0.466016918044265 506 16478292 SGTC_1773 st048542 73.5835 µM 0.0849244237482896 0.464515912706875 no 1546 0.46616073729163 506 3237138 SGTC_3178 9107506 49.47 µM 0.084460348004327 0.4647361888111 no 1547 0.466345213930704 501 8897194 SGTC_3196 9111891 49.47 µM 0.0839584268559318 0.464974440608312 no 1548 0.466544742788874 516 18891510 SGTC_1978 st071761 42 µM 0.083717086943901 0.465089004249407 no 1549 0.466640685709976 472 5147680 SGTC_261 5-fluorouridine 15.376 µM 0.0835763370430547 0.465155819321794 no 1550 0.466696640701361 507 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2743 auranofin 4.32 µM 0.082780881112297 0.465533446847513 no 1551 0.4670128858021 521 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1935 st074532 41.6 µM 0.082772233229336 0.465537552436115 no 1552 0.467016324008823 517 2829742 SGTC_1600 coumarin 106 71.1 µM 0.0817701691048454 0.466013307818941 no 1553 0.46741473910861 524 100336 A hepatotoxic, DNA x-linker. SGTC_1953 st076800 12.1 µM 0.0817643281704906 0.466016081093862 no 1554 0.467417061527579 482 297591 SGTC_393 acivicin 6.25 µM 0.0813030571950952 0.466235097696911 no 1555 0.467600471375704 507 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2975 9084847 53.72 µM 0.081067924143395 0.466346745431007 no 1556 0.467693967263444 493 27211724 SGTC_3305 9127027 53.8275 µM 0.0795872424503546 0.467049874910444 no 1557 0.468282771039088 499 41905295 SGTC_776 4476-4378 112 µM 0.0774632880253854 0.468058653519515 no 1558 0.469127497699572 510 2892008 SGTC_192 3455-0609 60.9 µM 0.0773240353065339 0.468124799257803 no 1559 0.46918288536815 493 3769639 SGTC_2366 9070441 60.58 µM 0.0771904106836594 0.468188272449752 no 1560 0.469236035026349 492 6837235 SGTC_445 e6 berbamine 66 µM 0.0755888642468623 0.468949087413285 no 1561 0.469873098080405 520 6610268 A calcium/calmodulin antagonist. SGTC_3068 9116768 49.47 µM 0.0729422833529535 0.470206593437402 no 1562 0.470926023145169 520 41904888 SGTC_3353 9151644 39.2805 µM 0.07176142467802 0.470767767530426 no 1563 0.471395886142444 519 4909158 SGTC_607 4491-0986 66.8 µM 0.071503604867464 0.470890297825285 no 1564 0.471498477817298 515 698981 YDR232W HEM1 SGTC_3114 9122766 49.47 µM 0.0714006462185822 0.470939230264846 no 1565 0.471539447658013 518 17176985 SGTC_124 0136-0217 7.121 µM 0.0708620811700693 0.471195197455616 no 1566 0.471753761159744 502 3976905 SGTC_3153 9100258 49.47 µM 0.0706454894270501 0.471298141733821 no 1567 0.471839952751437 515 25236848 SGTC_1463 k081-0032 34.1 µM 0.0681917282841182 0.472464526556089 no 1568 0.472816505759202 521 977755 SGTC_2522 biochanin a 4.94 µM 0.0672592284700483 0.472907848808718 no 1569 0.473187667160766 516 5280373 A possible chelator. SGTC_1835 st008666 49.2 µM 0.0668516716184891 0.473101617082843 no 1570 0.473349893688719 502 690455 SGTC_2634 4'-methoxyflavone 100 µM 0.0667717432447386 0.473139618867929 no 1571 0.473381709407531 504 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_3133 9127736 49.47 µM 0.0660227936201032 0.47349571729656 no 1572 0.47367983917986 505 27243420 SGTC_1800 st050079 29.0735 µM 0.0657737808148804 0.473614118575031 no 1573 0.473778965450044 518 3645560 SGTC_2011 4012611 177 µM 0.0655872059430283 0.47370283322511 no 1574 0.473853237679383 513 2049887 SGTC_699 0375-0592 111 µM 0.0653925592647809 0.473795387335512 no 1575 0.473930724123893 523 762578 SGTC_507 nimesulide 162 µM 0.0648403113493644 0.474057987809813 no 1576 0.474150572574182 520 4495 A COX2 inhibitor. SGTC_2833 9001315 45.46 µM 0.0647685896756499 0.474092093151068 no 1577 0.474179125363862 522 2989378 SGTC_2361 9034121 116 µM 0.0642627938110016 0.474332616347512 no 1578 0.474380489215201 520 6496917 SGTC_2171 5739187 198.077 µM 0.062731633768291 0.475060791877516 no 1579 0.474990103444652 520 2262761 SGTC_2022 5136654 200 µM 0.0615472480951542 0.475624108797635 no 1580 0.475461693581099 513 1713771 SGTC_1811 st050069 61.5 µM 0.0596876657720776 0.476508660290859 no 1581 0.476202197754194 528 3877702 SGTC_1446 4239-0190 62 µM 0.0595415623574381 0.476578162575805 no 1582 0.476260381102674 520 1340085 SGTC_3211 9128781 49.47 µM 0.0593756424008482 0.476657092574485 no 1583 0.476326456685809 496 17194361 SGTC_2493 resveratrol 26.09 µM 0.0577961492454409 0.47740852073849 no 1584 0.476955502755298 526 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_455 paf C-16 10 µM 0.0577503878306948 0.477430292486797 no 1585 0.476973728476599 513 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.0576962124985083 0.477456067382263 no 1586 0.476995305330384 527 23665772 A membrane-active detergent. SGTC_356 1634-0012 32.5 µM 0.0574820388265745 0.477557965307928 no 1587 0.477080606694656 523 735457 SGTC_1659 st012954 42.1 µM 0.0573219320106144 0.477634140673571 no 1588 0.477144374928486 508 24207262 SGTC_2752 diclazuril 33.15 µM 0.0567599846191882 0.47790150955652 no 1589 0.477368195084439 516 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_3265 9137266 49.47 µM 0.0547160304508028 0.478874085261922 no 1590 0.478182349020759 521 17224265 SGTC_248 streptozotocin 5.23457 mM 0.0542923469754998 0.479075702709132 no 1591 0.478351123395457 527 5300 DNA alkylating agent. SGTC_478 N-arachidonylglycine 10 µM 0.0538998133895538 0.479262501697248 no 1592 0.478507492672474 523 5283389 SGTC_2421 5690543 90.72 µM 0.0536957916651047 0.479359593411729 no 1593 0.478588767865719 520 3397993 SGTC_1512 0259-0544 12.2 µM 0.053526896789612 0.479439969568576 no 1594 0.478656050411959 499 18476 SGTC_1400 3771-8998 51.5 µM 0.0533376220839432 0.479530045369573 no 1595 0.478731452381135 512 670767 SGTC_1125 tnp00248 1.32998 µM 0.0527128220921614 0.479827394978049 no 1596 0.478980361339079 517 24207736 SGTC_441 propafenone 146 µM 0.0520965279563522 0.480120707549149 no 1597 0.479225889750367 531 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_513 4245-1575 41.7 µM 0.0520617933769744 0.48013723908269 no 1598 0.479239728063535 515 719745 SGTC_1279 0874-0590 65.2 µM 0.0519276755811519 0.480201071263993 no 1599 0.479293161047201 509 3523074 SGTC_3204 9114183 49.47 µM 0.0509496443633683 0.480666571837916 no 1600 0.479682823184378 517 17027248 SGTC_418 lividomycin a 100 µM 0.0486249305880495 0.481773139731028 no 1601 0.480609100862643 513 72394 An antibiotic. SGTC_2589 lobaric acid 100 µM 0.0485668446553393 0.481800790572228 no 1602 0.480632246451101 519 73157 A novel microtubule depolymerizer. SGTC_1570 verbenone 133 µM 0.0480103831616418 0.482065689219402 no 1603 0.480853983792248 525 29025 A natural terpanoid with antifungal properties. SGTC_266 formosanin C 406 nM 0.0475813616160148 0.482269926601096 no 1604 0.481024943239364 532 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2355 9061122 103.12 µM 0.0457582268190137 0.483137888292508 no 1605 0.481751477040633 523 5302957 SGTC_834 0312-0008 75.7 µM 0.0454406012948346 0.483289112383002 no 1606 0.481878059620602 528 6385573 YIL048W NEO1 SGTC_2793 7325131 81.82 µM 0.0451197509130383 0.483441874295058 no 1607 0.482005929250632 514 4176441 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.0450621432419481 0.483469302471167 no 1608 0.482028888034609 528 2374 Ca(2+)-ATPase inhibitor. SGTC_2194 5927483 104.545 µM 0.0443708417658739 0.483798451135826 no 1609 0.482304401824871 509 760979 SGTC_874 0599-0792 117 µM 0.044345675729773 0.483810433624495 no 1610 0.482314431748131 520 765305 SGTC_2936 9038235 15.59 µM 0.0439665995204237 0.483990927712885 no 1611 0.482465513915491 528 4749415 SGTC_815 1582-0027 36.9 µM 0.0436191849972912 0.48415634922591 no 1612 0.482603979417443 531 3128206 SGTC_1313 1220-0047 237 µM 0.0434670423915961 0.48422879282636 no 1613 0.482664618022709 523 3528706 SGTC_2676 harmalol 100 µM 0.0426062158305473 0.484638690214429 no 1614 0.483007720237618 522 5459187 A monoamine oxidase inhibitor SGTC_2755 lomerizine 42.69 µM 0.0425659695768086 0.484657854561658 no 1615 0.483023761617139 511 3949 A calcium channel blocker. SGTC_565 1418-0001 44.5 µM 0.0415552413193954 0.485139151787461 no 1616 0.483426627324473 513 2862145 SGTC_2814 7977482 42.97 µM 0.0409590889396035 0.485423042922252 no 1617 0.483664255384994 531 6456762 SGTC_2699 st077704 54.6 µM 0.0403364678994509 0.485719546468234 no 1618 0.483912440123249 524 645852 SGTC_2061 5245884 80.95 µM 0.0402929571647194 0.485740267374295 no 1619 0.483929784294722 524 573863 SGTC_1777 st045864 34.765 µM 0.040149150815639 0.485808751847692 no 1620 0.483987108341247 527 4691462 SGTC_1045 1348-1485 165 µM 0.0399952527827411 0.485882042717496 no 1621 0.484048455498541 520 6810614 SGTC_276 colchicine 750 µM 0.0392620363106317 0.486231228949477 no 1622 0.48434073694958 533 2833 A microtubule depolymerizer. SGTC_1173 0443-0020 122 µM 0.0390807171708465 0.48631758182206 no 1623 0.484413017345907 522 5331295 SGTC_2957 9076800 11.52 µM 0.0390216411296246 0.486345716805641 no 1624 0.484436567312872 527 16459615 SGTC_2491 paeonol 100 µM 0.0384492494392777 0.486618322030228 no 1625 0.484664747307167 531 11092 Increases levels of cortical cytochrome oxidase. SGTC_990 3985-0011 41.3 µM 0.0384001489464784 0.486641706748787 no 1626 0.484684321114449 536 5399565 YGL099W LSG1 SGTC_1222 0366-0074 1.18 µM 0.0380876860079628 0.486790522170763 no 1627 0.484808884664707 525 286520 SGTC_328 k915-0120 63.5 µM 0.0353000344190923 0.488118264368418 no 1628 0.485920247943383 515 6624543 SGTC_2091 4-phenylthiadiazole 200 µM 0.0352972130821227 0.488119608223961 no 1629 0.485921372792991 537 270010 SGTC_2540 epiandrosterone 100 µM 0.0352156918449634 0.488158438371431 no 1630 0.485953874854643 528 441302 A steroid. SGTC_932 2857-0803 154 µM 0.0341343845981244 0.4886734964763 no 1631 0.486384994754309 529 674898 SGTC_1756 st041558 35.5 µM 0.0333212018489759 0.489060851572809 no 1632 0.48670922325791 524 3955792 SGTC_1380 2291-0730 164 µM 0.0331430782935158 0.489145701131753 no 1633 0.486780245047046 526 2999191 SGTC_2183 6420625 130.508 µM 0.0325267030492856 0.489439316641707 no 1634 0.487026010669308 519 2897619 SGTC_1663 st014140 55.4 µM 0.032213629268846 0.489588454160876 no 1635 0.487150843617858 531 4207120 SGTC_2602 kawain 100 µM 0.0320637297812384 0.48965986160809 no 1636 0.487210613984998 530 5369129 SGTC_2127 5253358 187.912 µM 0.0306780753073285 0.490319959637052 no 1637 0.487763138150807 530 20612 SGTC_3327 9140648 26.9345 µM 0.0303562943156526 0.490473253513975 no 1638 0.487891450430429 531 8029710 SGTC_157 1348-1695 65.819 µM 0.030282955969699 0.490508191509976 no 1639 0.487920694752453 513 5380510 SGTC_762 1165-0429 115 µM 0.0299229319409641 0.490679706084064 no 1640 0.488064258496146 538 5967793 SGTC_1243 0416-0003 5.65 µM 0.0298347558040993 0.490721713245748 no 1641 0.488099419986621 530 2141977 SGTC_889 0919-1524 82.7 µM 0.0289492820187733 0.491143559087728 no 1642 0.488452520353224 512 3905452 SGTC_1473 k844-0725 134 µM 0.0288684800130959 0.491182054223007 no 1643 0.488484742222523 532 54682906 SGTC_568 1193-0097 7.48 µM 0.0272259769658109 0.491964581519826 no 1644 0.489139748380178 525 3646150 SGTC_98 0074-0023 107.663 µM 0.0271881914019414 0.491982583831524 no 1645 0.489154817061051 540 3563821 SGTC_3268 9137683 49.47 µM 0.0269183953112749 0.492111124222916 no 1646 0.489262410748303 542 1953228 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.0252472859182242 0.492907317526571 no 1647 0.489928860126673 537 4620898 SGTC_42 0133-0086 60.653 µM 0.0243624542278821 0.493328903646096 no 1648 0.490281748307981 540 162923 Model of phenazepam hydroxylation. SGTC_597 k018-0003 82.8 µM 0.0241637292843907 0.493423588997193 no 1649 0.490361004757505 540 6786234 SGTC_2065 5221596 34.26 µM 0.0236901038601305 0.493649256111215 no 1650 0.490549899883832 536 788581 SGTC_1523 st012844 44.7 µM 0.0224815204260887 0.4942251158597 no 1651 0.49103192641946 528 4274103 SGTC_2059 5238311 157 µM 0.0215853793506277 0.494652112483209 no 1652 0.491389348201881 535 703021 SGTC_1797 st048695 56.8 µM 0.0213970165555228 0.49474186508217 no 1653 0.491464476732921 538 592262 YIL048W NEO1 SGTC_26 0302-0163 425.158 µM 0.0209936358817101 0.494934071995313 no 1654 0.491625366194513 537 3100915 SGTC_2997 9067075 71.4286 µM 0.020310832553783 0.495259423704331 no 1655 0.491897707221003 537 27209819 SGTC_2874 9043904 71.43 µM 0.0193125594922985 0.495735100473025 no 1656 0.492295882385883 532 4463428 SGTC_381 3461-2219 42.7 µM 0.0192547315778929 0.495762655646564 no 1657 0.492318948096929 533 2883159 SGTC_2524 avocatin b 10.57 µM 0.0187930816782235 0.495982633913397 no 1658 0.492503086435337 542 6710748 SGTC_1747 st037496 66.6 µM 0.0187681925701222 0.49599449372137 no 1659 0.492513014001938 537 723305 SGTC_2013 4024628 200 µM 0.0176706127401384 0.496517500405954 no 1660 0.492950812311395 539 5230760 SGTC_648 0375-0473 33.3 µM 0.0172500885504848 0.496717885608673 no 1661 0.49311855161857 534 1713139 SGTC_2729 fluphenazine 10.66 µM 0.0169906717310823 0.496841501486788 no 1662 0.493222028789712 543 3372 An atypical antipsychotic. SGTC_2553 4-methylesculetin 85.09 µM 0.0160555454891842 0.497287105139468 no 1663 0.493595039249679 519 5319502 SGTC_170 4197-0004 226 µM 0.0158320340889551 0.497393612667649 no 1664 0.493684196064448 533 218692 SGTC_1715 st032160 10.2275 µM 0.0149772894859074 0.497800916738445 no 1665 0.494025149358048 543 5289825 SGTC_1539 benzyladenosine 56 µM 0.0144679890719897 0.498043610387403 no 1666 0.494228308805171 536 92208 A nucleotide analog. SGTC_1709 st033179 39.1045 µM 0.0143797878480848 0.498085640425133 no 1667 0.494263492342426 542 573381 SGTC_1020 4335-0961 93.3 µM 0.0136972252045195 0.498410898881171 no 1668 0.494535768603303 538 669075 SGTC_2737 bleomycin 30.5 nM 0.0130703117161481 0.49870964003552 no 1669 0.494785848497058 544 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1751 st044839 27.194 µM 0.0130607710220353 0.498714186439125 no 1670 0.494789654358464 543 5291326 SGTC_1965 Pectolinarigenin 58.4 µM 0.0129833237373059 0.498751092210208 no 1671 0.494820548735288 539 5320438 An anti-inflammatory. SGTC_2645 abamectin 100 µM 0.0128984766730633 0.498791524192946 no 1672 0.494854394982391 542 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_517 1365-0151 113 µM 0.0116651726663016 0.499379228997143 no 1673 0.495346374956779 531 768657 SGTC_2132 5317594 122.667 µM 0.0115805010170694 0.499419577535399 no 1674 0.495380151776061 541 794577 SGTC_1101 ebselen 5.29 µM 0.011260202136668 0.499572209449395 no 1675 0.495507924208677 543 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2229 7354935 190 µM 0.0109915347602614 0.49970023746998 no 1676 0.495615100350566 544 318112 SGTC_1068 loratadine 26.9 µM 0.0106516174791527 0.499862218238474 no 1677 0.495750699785165 541 3957 A H1 histamine antagonist. SGTC_1053 3366-3204 134 µM 0.0106016945157185 0.499886008028814 no 1678 0.495770615041535 536 3632071 YPR165W RHO1 SGTC_1854 st056233 32.9 µM 0.010123269382797 0.499886008028814 no 1679 0.495961468805932 541 5393174 SGTC_811 0416-0114 265 µM 0.0101100434383749 0.499879705469323 no 1680 0.495966744924356 544 6612453 SGTC_2028 5153890 36.43 µM 0.00948246603680497 0.49958064606341 no 1681 0.496217100066804 543 2830968 YPR165W RHO1 SGTC_1185 1319-0113 81.3 µM 0.00868496033006616 0.499200611098544 no 1682 0.496535245677673 545 4672763 SGTC_1681 tripelennamine 100 µM 0.00841923496470706 0.499073985277413 no 1683 0.496641250883983 545 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_3173 9105693 49.47 µM 0.00806922174289058 0.498907193999584 no 1684 0.496780881210924 537 17096658 SGTC_2276 7947513 42.08 µM 0.00767235167321654 0.498718074330688 no 1685 0.496939204556419 534 2105100 SGTC_3188 9110789 49.47 µM 0.00726876689905327 0.498525755213309 no 1686 0.497100207092687 542 849217 SGTC_2280 7785178 200 µM 0.00679625306017465 0.49830058996119 no 1687 0.497288708178006 542 2954328 SGTC_1192 1488-0095 21.4 µM 0.00594812314434482 0.497896435190572 no 1688 0.49762705618122 543 915875 SGTC_1210 3013-0140 750 nM 0.00502978783535024 0.497458828270202 no 1689 0.497993413431727 543 905973 SGTC_2406 ethylparaben 405.7 µM 0.00493857664075793 0.497415364293367 no 1690 0.49802980098171 533 8434 A possible steroid mimic. SGTC_1728 st035614 33.7865 µM 0.00375988712422801 0.496853697871667 no 1691 0.498500025590737 537 15945546 SGTC_1865 st057639 52.2 µM 0.00372979560903511 0.496839358808857 no 1692 0.498512030284252 545 688818 SGTC_740 k014-0057 261 µM 0.00261590959995473 0.496308578282197 no 1693 0.498956404249088 547 4012779 SGTC_2394 5221648 200 µM 0.00187174496506327 0.495953978168445 no 1694 0.49925328223132 547 788586 SGTC_2290 7904846 200 µM 0.00110935269952217 0.495590695767481 no 1695 0.499557432395058 548 2962154 SGTC_2462 5162487 171.77 µM 0.000859182364998861 0.495471489569268 no 1696 0.499657235870198 547 2259986 SGTC_864 0469-0573 172 µM 0.000137079806169138 0.495127409907986 no 1697 0.499945313069701 547 689425 SGTC_1679 SEC14.276 6.7 µM -0.000258265030703823 0.494939030821301 no 1698 0.499896967160848 549 1005053 YMR079W SEC14 SGTC_963 1269-2853 151 µM -0.00149513502741443 0.494349678283948 no 1699 0.499403527644884 550 3668223 SGTC_1211 1056-0033 32.3 µM -0.00199993672392453 0.494109150283 no 1700 0.499202141214571 548 6741922 SGTC_673 1082-0474 110 µM -0.00204114063010295 0.494089517531911 no 1701 0.499185703267835 549 3098046 SGTC_440 fluspirilene 35.1 µM -0.00218368844288157 0.494021596758776 no 1702 0.499128835045268 551 3396 An atypical antipsychotic. SGTC_2141 5621638 7.665 µM -0.00222434047181956 0.494002227028255 no 1703 0.499112617271532 550 2856238 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.00308233137589279 0.493593418020939 no 1704 0.498770329639084 551 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2149 5554786 194.827 µM -0.00310604752048154 0.493582118025584 no 1705 0.498760868311571 551 745063 YPR165W RHO1 SGTC_1859 st055998 20 µM -0.00342445501905211 0.49343040739119 no 1706 0.498633842775698 551 676301 SGTC_3276 9139060 49.47 µM -0.00354010521259597 0.493375304135859 no 1707 0.498587705303521 550 4870619 SGTC_537 1334-0398 209 µM -0.00553247436724557 0.492426030950176 no 1708 0.497792873319064 558 5846986 SGTC_2905 7799065 20.05 µM -0.00663001767346746 0.491903119516229 no 1709 0.497355025007846 554 1296806 SGTC_1283 0922-0125 16.4 µM -0.00732080658493838 0.491574008446163 no 1710 0.497079446814106 550 3360884 SGTC_603 3794-0023 45.9 µM -0.00751057831372965 0.491483596905877 no 1711 0.497003740929637 555 3802260 SGTC_108 0509-0257 621.132 µM -0.0083143201316454 0.491100681046191 no 1712 0.496683104381753 554 536624 SGTC_2436 5633522 8.09 µM -0.00862090947242985 0.490954618968771 no 1713 0.49656079731629 556 5724242 SGTC_2413 inermin 26.06 µM -0.00912824390748484 0.490712922693032 no 1714 0.496358408132066 562 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_296 1222-0039 74.9 µM -0.0129596127513447 0.488887758702965 no 1715 0.494830007254324 565 5984176 SGTC_217 ketoconazole 989 nM -0.0145921682282735 0.488110120413492 no 1716 0.494178773718696 554 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2159 5658611 73.75 µM -0.0151887851376402 0.487825943855574 no 1717 0.493940784397584 565 793844 SGTC_1841 st054148 70 µM -0.0163586113363556 0.487268758175288 no 1718 0.493474149348041 559 675442 SGTC_561 1550-0330 72.9 µM -0.0180427549585956 0.486466648141501 no 1719 0.492802372714684 563 6812934 SGTC_1214 0358-0031 63.7 µM -0.0186669981433411 0.486169352480307 no 1720 0.492553377666014 571 4301366 SGTC_1633 st005664 67.9 µM -0.019463538579241 0.485790011480047 no 1721 0.492235661764125 563 2063822 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.0197849215199342 0.485636961068323 no 1722 0.492107473207185 562 75037 A free radical scavenger. SGTC_2470 5664817 21.68 µM -0.0199733689841407 0.48554721876234 no 1723 0.492032308399487 560 2859561 SGTC_3143 9086658 49.47 µM -0.0217355728378187 0.484708059441225 no 1724 0.491329443724183 567 25236626 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.0222136676243709 0.484480402811591 no 1725 0.491138757546807 561 1273210 SGTC_2448 5185112 27.17 µM -0.0229440362346453 0.48413262956823 no 1726 0.490847456897027 556 5718189 SGTC_1838 st055369 84.5 µM -0.023370926134625 0.483929366704572 no 1727 0.490677198126507 553 676036 SGTC_1692 fluoroquinolonic acid 71 µM -0.0250093074495285 0.483149293602399 no 1728 0.490023769830228 576 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2649 anisomycin 9.56 µM -0.0257323904369192 0.482805036583038 no 1729 0.489735394286317 571 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2485 5633444 17.78 µM -0.0264791346419543 0.482449528007744 no 1730 0.489437587953614 563 5724239 SGTC_2907 7721985 69.9 µM -0.0265540773416209 0.482413850194204 no 1731 0.489407700651299 568 3267881 SGTC_286 k060-0067 22.9 µM -0.0266806086564672 0.48235361301682 no 1732 0.489357239838525 563 5985051 SGTC_2619 obliquin 87.91 µM -0.0267933487325769 0.482299941709952 no 1733 0.489312279128808 566 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2372 9071633 200 µM -0.0268049522427196 0.482294417733702 no 1734 0.48930765166002 556 21321366 SGTC_909 3448-9333 149 µM -0.0272380729319747 0.482088228395111 no 1735 0.48913492457681 558 3344074 SGTC_2646 retinol 96.75 µM -0.0273517352429648 0.482034119656949 no 1736 0.489089596763316 561 445354 A vitamin A analog and teratogen. SGTC_2794 7785382 27.27 µM -0.0279495760978985 0.481749524067535 no 1737 0.488851183930613 562 2205081 SGTC_3233 9132340 49.47 µM -0.0281946020613935 0.481632884820766 no 1738 0.488753471222677 574 17682950 SGTC_696 1560-0013 611 µM -0.0281946404361605 0.481632866553421 no 1739 0.488753455919444 561 1650269 SGTC_2017 5132927 60.65 µM -0.0283831625670404 0.481543125789273 no 1740 0.488678276558366 566 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_510 ag-490 170 µM -0.0292382652560682 0.481136089532618 no 1741 0.48833728150409 561 5328779 SGTC_1115 galangin 695.678 nM -0.0293472814495609 0.481084198288597 no 1742 0.488293808990436 566 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_91 0417-1751 58.384 µM -0.0294070942635959 0.481055727779849 no 1743 0.488269957424412 556 6795624 SGTC_2249 haloperidol 116.36 µM -0.0309047694881994 0.480342876036384 no 1744 0.487672743119982 560 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3343 9148379 18.9835 µM -0.0321808705675864 0.47973553693051 no 1745 0.48716390567661 561 1955036 SGTC_484 loperamide 105 µM -0.0322275848760406 0.479713304915567 no 1746 0.487145279025338 559 3955 An opioid-receptor agonist. SGTC_1563 conessine 56.1 µM -0.0343072908370623 0.478723607734889 no 1747 0.486316055523143 559 441082 An anti-amoebic, histamine inhibitor. SGTC_1344 1488-0097 29.1 µM -0.0360347510490568 0.477901637865944 no 1748 0.485627324804407 557 747966 SGTC_1137 ixabepilone 100 µM -0.0378791624992355 0.477024123438207 no 1749 0.484892013520327 567 154225 A novel microtubule stabilizer. SGTC_72 0744-0168 198.391 µM -0.0379771078701822 0.476977527110582 no 1750 0.484852967065816 572 677577 SGTC_1579 chlormadinone acetate 49.4 µM -0.0383613617133739 0.476794726029984 no 1751 0.484699783588729 573 45114258 A steroidal progestin. SGTC_481 bay k-8644 50 µM -0.0390191864652087 0.476481790417732 no 1752 0.484437545837061 589 2303 A calcium channel antagonist. SGTC_2621 lithochol-11-enic acid 100 µM -0.0418641354980762 0.47512858138754 no 1753 0.483303503522632 576 6708711 SGTC_3177 9107506 49.47 µM -0.0422718616397793 0.474934668291428 no 1754 0.483140988193678 557 8897194 SGTC_691 1548-0686 185 µM -0.0440544032357426 0.474086968204109 no 1755 0.48243051920855 562 46495133 SGTC_1506 4226-2149 212 µM -0.0442358905687998 0.474000667153002 no 1756 0.482358186753012 589 991114 SGTC_612 0302-0167 22.4 µM -0.0442790945799774 0.473980122914955 no 1757 0.482340967718214 563 235821 SGTC_1904 st060225 78 µM -0.0443514675434809 0.473945708501803 no 1758 0.482312123419884 561 66595 SGTC_2612 dictamnine 15.46 µM -0.0447201421874422 0.473770401286411 no 1759 0.482165189307152 568 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1670 st016595 4.04 µM -0.0447336858602602 0.473763961277523 no 1760 0.482159791565217 559 597879 SGTC_2514 salinomycin 42.74 µM -0.0453398881700783 0.47347571946318 no 1761 0.481918196975957 582 23682228 A polyether potassium ionophore. SGTC_2344 7990960 76.95 µM -0.0457542999301387 0.47327867970144 no 1762 0.481753042003547 578 140813 SGTC_941 3237-0776 460 µM -0.0458520843711935 0.473232187225859 no 1763 0.481714072554742 571 760008 SGTC_1366 1683-0113 21.9 µM -0.0461423068944611 0.473094200515142 no 1764 0.481598412937586 579 708623 SGTC_259 usnic acid 108.925 µM -0.046783423998908 0.472789391944805 no 1765 0.481342920149838 601 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_689 0833-0039 98 µM -0.0473452855847701 0.472522277199988 no 1766 0.48111901792552 576 5374726 SGTC_1063 disulfiram 1.84 µM -0.047420321475456 0.472486605302771 no 1767 0.481089116521303 557 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1437 4092-1038 11.6 µM -0.0485124902890448 0.471967415781095 no 1768 0.48065390517585 572 3977136 SGTC_340 k038-0059 454 µM -0.0510497292241564 0.470761461703295 no 1769 0.479642946993882 573 23733424 SGTC_1814 st052110 31.539 µM -0.0516556694577744 0.47047349649879 no 1770 0.479401530348821 585 674163 SGTC_3239 9133757 49.47 µM -0.0517832293833695 0.470412877267672 no 1771 0.47935070931735 565 17036923 SGTC_3051 9093778 49.47 µM -0.0518044971870187 0.470402770414779 no 1772 0.479342236064082 572 17217378 SGTC_1622 st003707 19.4 µM -0.0525058005551922 0.470069508827013 no 1773 0.479062836768715 571 10140899 SGTC_491 tetrandrine 80.3 µM -0.0528460858045472 0.469907811735286 no 1774 0.478927270807697 583 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1260 0700-1617 7.75 µM -0.0528575365361627 0.469902370651113 no 1775 0.478922709002442 569 2853078 SGTC_1701 st028638 40.4 µM -0.0528792584686092 0.469892048979977 no 1776 0.478914055307463 575 3490878 SGTC_357 1325-0123 420 µM -0.0534390728957251 0.469626047398457 no 1777 0.478691037002308 595 1098503 SGTC_3062 9077494 49.47 µM -0.0535279932934027 0.46958379720165 no 1778 0.478655613596463 565 16459633 SGTC_1174 0739-0097 51.1 µM -0.0545634810532393 0.469091814376103 no 1779 0.478243116646538 590 728447 SGTC_3227 9130768 49.47 µM -0.0549629584925728 0.468902026502883 no 1780 0.478083987001687 570 17720899 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.0556595100009655 0.468571118536803 no 1781 0.477806527904723 571 5282362 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.0561185032981085 0.468353078262337 no 1782 0.477623701832793 597 6710655 SGTC_1652 st011932 78 µM -0.0565285977352141 0.468158274940535 no 1783 0.477460357122279 579 1551076 SGTC_3128 9127691 49.47 µM -0.0565324620531631 0.468156439345939 no 1784 0.477458817943807 575 41316314 SGTC_2532 xanthone 78.9 µM -0.0568844713384251 0.467989233811139 no 1785 0.477318612179255 584 7020 An insecticide. SGTC_143 4032-1194 15.74 µM -0.0568871254792546 0.467987973107181 no 1786 0.477317555042089 570 1806963 SGTC_1754 st042065 16.137 µM -0.0569789026938018 0.467944379575173 no 1787 0.477281000522202 577 1126236 YIL048W NEO1 SGTC_3067 9117431 49.47 µM -0.0574685380794263 0.467711812716423 no 1788 0.477085983824742 579 17150885 SGTC_1113 artemisinin 1.17947 µM -0.0576785074798257 0.467612084889447 no 1789 0.47700235686798 585 2240 An anti-malaria and mitochondrial poison. SGTC_925 2064-1272 59.6 µM -0.0579512713512551 0.467482535009626 no 1790 0.476893721539371 610 6815817 SGTC_2598 perillyl alcohol 100 µM -0.0585237326947893 0.467210654285133 no 1791 0.476665729466372 575 10819 An apoptosis inducer. SGTC_128 0906-2981 13.371 µM -0.0591900483280466 0.466894218344003 no 1792 0.476400368015107 580 6740226 SGTC_2416 tofa 880 nM -0.0592626468770381 0.46685974226515 no 1793 0.476371456136888 574 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1810 st050138 53 µM -0.0596041829068117 0.466697554718179 no 1794 0.476235443408226 574 3444541 SGTC_2528 xanthyletin 44.79 µM -0.0599721751582263 0.466522809914087 no 1795 0.476088897898032 573 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2686 alizarin 95.37 µM -0.0600996276950431 0.466462289304041 no 1796 0.476038143242597 580 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_394 menadione 8.33 µM -0.0609570384925678 0.466055169539387 no 1797 0.475696711854961 571 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_634 1611-4317 11.2 µM -0.061164419418148 0.465956705286462 no 1798 0.475614132923492 581 2843522 SGTC_2823 7987624 58.44 µM -0.0627938025392594 0.465183148818977 no 1799 0.474965350494339 582 2239440 SGTC_1489 4065-0444 182 µM -0.0632276170462354 0.464977215618021 no 1800 0.474792626774349 568 2877968 SGTC_2301 7769476 200 µM -0.0641980143012405 0.464516598827587 no 1801 0.474406279246673 592 977820 SGTC_3310 9130229 44.1445 µM -0.0643987912927616 0.464421302275899 no 1802 0.474326346219796 605 7761258 SGTC_2387 9077560 195.08 µM -0.0655371036530217 0.463881053802076 no 1803 0.473873182689336 570 5303272 SGTC_2233 sulbentine 40.3845 µM -0.0659844253584504 0.463668770959208 no 1804 0.473695112596258 585 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2345 9052315 157.45 µM -0.0669098648108506 0.463229623480226 no 1805 0.473326729828239 582 6469265 SGTC_175 3793-3120 23.7 µM -0.067375983158004 0.46300845393109 no 1806 0.473141194198551 586 5322297 SGTC_2761 levamisole 97.89 µM -0.0673813483782048 0.463005908242052 no 1807 0.473139058638473 576 26879 An alkaline phosphatase inhibitor. SGTC_1973 st070275 50.2 µM -0.067649519603969 0.462878668323493 no 1808 0.473032317357095 568 17118334 SGTC_146 3448-8650 53.125 µM -0.0688715359954703 0.462298903218435 no 1809 0.472545937844954 606 2891488 YIL048W NEO1 SGTC_53 0973-0023 39.979 µM -0.0695554207905548 0.46197448046364 no 1810 0.472273760006688 592 674768 SGTC_1037 k284-1091 78.7 µM -0.0700981845750036 0.461717020995934 no 1811 0.47205775582455 570 3334711 SGTC_3013 9080133 71.4286 µM -0.0704622494337517 0.461544336170226 no 1812 0.47191287321257 577 17050193 SGTC_3121 9125696 49.47 µM -0.0708612324860971 0.461355097122602 no 1813 0.471754098886671 571 1235365 SGTC_2822 7994718 71.43 µM -0.0708804384049578 0.461345987908966 no 1814 0.471746456051465 566 1018011 SGTC_137 0438-0332 85.389 µM -0.0723484612819373 0.460649776775045 no 1815 0.471162299592827 597 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1149 3909-7961 23.3 µM -0.0723750261389826 0.460637179472902 no 1816 0.471151729458223 578 735261 SGTC_1922 5578187 25 µM -0.0732027463550235 0.46024468670763 no 1817 0.470822390489193 575 1350412 SGTC_424 splitomicin 100 mM -0.0733093174766251 0.460194155054054 no 1818 0.470779988689203 612 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1464 k208-0027 110 µM -0.0734361349672774 0.460134024240691 no 1819 0.470729531831964 574 X1464 SGTC_2302 7771753 200 µM -0.0744778735151912 0.459640116072414 no 1820 0.470315073319211 575 2203047 SGTC_2741 miltefosine 3.04 µM -0.0763839377339295 0.458736576339301 no 1821 0.469556824050519 575 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_3084 9116877 49.47 µM -0.0765386398629607 0.458663251519623 no 1822 0.469495286976592 581 27241325 SGTC_869 0564-0080 44.1 µM -0.0775453206241097 0.458186145264032 no 1823 0.469094869572121 581 6843321 SGTC_531 3788-1495 174 µM -0.0787286534661298 0.457625393597222 no 1824 0.468624227020076 574 2896655 SGTC_536 3852-0578 10.6 µM -0.0789759295163049 0.457508226314104 no 1825 0.468525884356506 585 2869208 SGTC_2306 7482397 179.52 µM -0.0790212875608734 0.457486734625755 no 1826 0.468507845490982 594 891448 SGTC_2941 9056145 11.23 µM -0.0791733650111284 0.457414677727518 no 1827 0.468447364857591 578 2119517 SGTC_1849 st056239 19.2 µM -0.0798506633755959 0.457093779206198 no 1828 0.468178014693311 584 5393181 SGTC_366 0181-0206 4.31 µM -0.0807946440427425 0.456646575463613 no 1829 0.467802633790316 601 274874 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.0814568065560704 0.456332913681983 no 1830 0.467539337027646 592 1377 SGTC_2046 4110841 106 µM -0.0816045909819814 0.456262912933314 no 1831 0.467480575199159 591 44119630 YMR134W ERG29 SGTC_1085 doxorubicin 7.67 µM -0.081779638494504 0.456180000290153 no 1832 0.467410973978741 576 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_688 0527-0193 473 µM -0.0817887425948372 0.456175688112965 no 1833 0.467407354094535 581 4007154 SGTC_1514 1189-1591 158 µM -0.0824555135467244 0.455859884647478 no 1834 0.467142246433137 604 767698 YMR146C TIF34 SGTC_3154 9100113 49.47 µM -0.0825337367933055 0.455822837508187 no 1835 0.467111145878308 595 25237525 SGTC_1629 st005085 44.9 µM -0.0826301159816271 0.455777192101581 no 1836 0.467072827031127 578 24207091 SGTC_655 k060-0012 42 µM -0.0832258626632348 0.455495058072519 no 1837 0.466835974320863 592 5994525 SGTC_2002 4023503 131 µM -0.0843848311045972 0.454946257610883 no 1838 0.466375233646182 597 4736863 YCR052W RSC6 SGTC_2893 9048488 25.97 µM -0.0847780464122486 0.454760079837461 no 1839 0.466218923559576 577 6467338 SGTC_3250 9135583 49.47 µM -0.0862062869144015 0.454083926998751 no 1840 0.465651216540172 579 7699353 SGTC_875 0709-0210 25.7 µM -0.0862358992350982 0.454069909434125 no 1841 0.465639446763547 587 6251364 SGTC_3058 9093861 49.47 µM -0.0869810170243957 0.453717212396874 no 1842 0.465343300565815 590 17217477 SGTC_1180 1193-0155 285 µM -0.0874447335576579 0.453497733364305 no 1843 0.465159006648303 597 2921347 SGTC_3180 9109287 49.47 µM -0.0876494960523349 0.453400822909948 no 1844 0.465077630683124 586 18891271 SGTC_216 k038-0035 28.382 µM -0.0876862277190765 0.453383438757414 no 1845 0.465063033072247 584 4444231 YPR107C YTH1 SGTC_3031 9088762 49.47 µM -0.090956259446481 0.451836178742494 no 1846 0.463763673417348 600 205253 SGTC_2400 5203494 178.7 µM -0.0911549934379559 0.451742168385968 no 1847 0.463684718019734 585 6777674 SGTC_994 3910-0338 138 µM -0.0923542614926049 0.451174916830758 no 1848 0.463208289049312 590 3479481 SGTC_1151 3909-8316 15.3 µM -0.0928561916088008 0.450937534348243 no 1849 0.46300890467486 606 800431 SGTC_993 3909-8757 62.7 µM -0.0930475779717014 0.450847024830219 no 1850 0.462932881694624 581 4288324 YLR208W SEC13 SGTC_3103 9120822 49.47 µM -0.0934868990810324 0.45063927287903 no 1851 0.462758378565756 577 17141819 SGTC_84 0443-0269 128.823 µM -0.0940535452553795 0.450371329752552 no 1852 0.462533311122733 584 6150058 SGTC_2872 9044037 25.97 µM -0.0951949933959326 0.44983165576465 no 1853 0.462079973310112 579 6465195 SGTC_3089 9117425 49.47 µM -0.0954164081551803 0.449726982100899 no 1854 0.461992041857989 588 9401657 SGTC_1393 3470-5649 58.2 µM -0.0954272858222097 0.449721839781935 no 1855 0.461987722008361 583 4108395 SGTC_1422 4031-0024 15.5 µM -0.0954872503140899 0.449693492260901 no 1856 0.461963908380722 599 782427 SGTC_836 0330-0104 1.35 µM -0.0963870634126329 0.449268146919509 no 1857 0.461606583092713 584 46494820 SGTC_1246 0422-0085 105 µM -0.0972050696483409 0.448881522586238 no 1858 0.461281771058218 597 264295 SGTC_1066 ketoconazole 628 nM -0.0974999639393043 0.448742154959414 no 1859 0.461164681433669 585 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2909 7941780 10.49 µM -0.0975645390591091 0.448711637473259 no 1860 0.461139041927008 607 1243215 SGTC_1671 st016596 74.5 µM -0.0976514541012596 0.448670562866446 no 1861 0.461104532624676 587 2829167 SGTC_2779 methotrexate 400 µM -0.097854046919083 0.448574822998792 no 1862 0.461024095018435 608 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.0980830040637702 0.448466627670754 no 1863 0.460933191619403 602 5377381 SGTC_1268 0828-0275 2.46 µM -0.0981876575083573 0.448417174216681 no 1864 0.46089164149321 612 745337 SGTC_2446 5162541 200 µM -0.0982764574183823 0.448375212898492 no 1865 0.460856385965386 593 1549321 SGTC_2835 9006588 71.43 µM -0.0988628933967689 0.448098114228269 no 1866 0.460623565652777 596 2345538 SGTC_690 glyoxal 20.3 µM -0.0988949368090056 0.448082974025299 no 1867 0.460610844520587 601 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1054 3429-0080 167 µM -0.0990111910600251 0.448028045648961 no 1868 0.460564692293216 628 1162877 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.0993011383727825 0.447891054270691 no 1869 0.460449587297603 597 688798 SGTC_1381 2324-0066 62.1 µM -0.102168985750905 0.446536420011704 no 1870 0.459311272345077 614 10885928 SGTC_2315 7733312 200 µM -0.103252710113367 0.446024681843976 no 1871 0.458881203401074 605 726316 SGTC_2037 5169046 200 µM -0.103311049452874 0.445997136360458 no 1872 0.458858053175228 604 5718022 SGTC_1365 1672-3266 55.4 µM -0.104311053059404 0.44552501561679 no 1873 0.458461253346451 590 6415873 SGTC_1498 4478-3555 97.6 µM -0.104456204392435 0.4454564933124 no 1874 0.458403660960581 593 3437919 SGTC_1940 st075990 51.1 µM -0.105116034661956 0.445145024557129 no 1875 0.458141867986018 610 1084979 SGTC_3218 9131285 49.47 µM -0.106076306250244 0.444691794902331 no 1876 0.457760904969041 612 17156417 SGTC_2133 5320837 200 µM -0.106217132324993 0.44462533377817 no 1877 0.457705039105723 609 2841355 SGTC_2097 5376186 200 µM -0.10691622668202 0.444295427925819 no 1878 0.457427719974922 601 742755 SGTC_430 0958-0115 16.4 µM -0.107393477479556 0.444070233223563 no 1879 0.457238414399623 609 6833180 SGTC_469 w7 172 µM -0.107680911633648 0.443934613768626 no 1880 0.457124405884001 595 45115570 A P450 inhibitor. SGTC_1686 st019653 115.5 µM -0.108007123590409 0.443780705818713 no 1881 0.456995020730701 596 97252 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.108216108603518 0.443682110408208 no 1882 0.456912133588831 601 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2010 4012422 159 µM -0.108460404706876 0.443566860273391 no 1883 0.45681524382244 606 952393 SGTC_856 0433-0016 11.3 µM -0.110120654006639 0.442783741172837 no 1884 0.456156844122207 604 3911780 SGTC_3193 9111931 49.47 µM -0.110359227938123 0.442671227087135 no 1885 0.456062243477633 603 17087244 SGTC_2723 salbutamol 83.58 µM -0.110626701557655 0.442545089089124 no 1886 0.455956186331944 587 9884233 β2-adrenoceptor agonist SGTC_2452 5863136 48.41 µM -0.110884351166688 0.442423589507353 no 1887 0.455854027515321 591 2184096 SGTC_2722 naftopidil 47.16 µM -0.111336034477762 0.442210602711907 no 1888 0.455674940820719 618 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1550 gossypolone 36.6 µM -0.112133418696635 0.441834644885087 no 1889 0.455358810112998 597 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1392 3455-1037 33.9 µM -0.112738245124213 0.441549510847195 no 1890 0.455119039649429 594 981132 SGTC_407 eburnamonine 100 µM -0.112855629936276 0.441494175491557 no 1891 0.4550725068503 598 3195 SGTC_3289 9119912 71.43 µM -0.113111800201372 0.44137342045657 no 1892 0.45497095991325 631 17014829 SGTC_449 xestospongin c 11.1929 µM -0.113396428474359 0.441239257111446 no 1893 0.454858135557009 619 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2855 9016525 58.44 µM -0.113471655014953 0.441203799200849 no 1894 0.454828316969894 598 43811474 SGTC_2963 9082507 9 µM -0.113613429769826 0.441136975176287 no 1895 0.45477212043623 611 16459611 SGTC_878 0828-0289 13.7 µM -0.113884611022069 0.441009161443839 no 1896 0.454664632408789 586 745350 YLR208W SEC13 SGTC_2112 5488546 200 µM -0.114012064937415 0.440949091711405 no 1897 0.454614114686797 610 600757 SGTC_2356 9061756 188.97 µM -0.114093290786564 0.440910810229967 no 1898 0.454581920336014 604 20104043 SGTC_2896 9052656 71.43 µM -0.114248560718651 0.440837633547256 no 1899 0.454520379000866 609 6469436 SGTC_349 k015-0014 24 µM -0.114279769432402 0.440822925533493 no 1900 0.454508009539279 604 2196908 SGTC_3272 9137413 49.47 µM -0.115040600716773 0.440464386970098 no 1901 0.454206470468814 640 17614870 SGTC_2626 ethyl orsellinate 100 µM -0.115723845364914 0.440142452369671 no 1902 0.453935703675063 600 75653 A natural product. SGTC_1929 genistein trimethyl ether 50.5 µM -0.117195979155505 0.439448939818946 no 1903 0.453352376566215 590 136420 SGTC_492 tmb-8 126 µM -0.11776258448168 0.439182065174607 no 1904 0.453127888230218 624 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1094 duloxetine 25.4 µM -0.117931205621632 0.439102648897127 no 1905 0.453061083630031 598 60834 A selective serotonin reuptake inhibitor. SGTC_2055 5235184 200 µM -0.118033675942953 0.439054389173582 no 1906 0.45302048741864 610 2836034 SGTC_2713 st079149 53.4 µM -0.118141132440846 0.439003782118803 no 1907 0.452977916334629 591 3103253 SGTC_1644 st010134 20.9 µM -0.119573457268162 0.43832931871951 no 1908 0.452410523433671 598 3818134 SGTC_321 4534-3890 65.3 µM -0.120444569873001 0.437919210411077 no 1909 0.452065493352612 611 699746 SGTC_3293 9120939 62.045 µM -0.120572526141246 0.437858975895444 no 1910 0.452014815506121 611 934087 SGTC_2363 9053361 176 µM -0.121950488644033 0.437210401241096 no 1911 0.451469114917891 621 6469797 YMR079W SEC14 SGTC_883 0850-0245 24.6 µM -0.123211127948842 0.436617195585987 no 1912 0.450969956942135 596 6823229 YPR165W RHO1 SGTC_2145 5634607 200 µM -0.123695546377842 0.436389285777141 no 1913 0.450778169027561 614 308662 SGTC_130 0136-0219 337.655 µM -0.124216556823305 0.43614418368028 no 1914 0.45057190665848 608 234244 SGTC_1808 st050063 61.5 µM -0.124385298323618 0.436064806847205 no 1915 0.450505106592698 606 4011993 SGTC_760 0568-0725 82.9 µM -0.124740706955056 0.43589762930345 no 1916 0.450364414791238 595 3916171 SGTC_2353 9059630 146.67 µM -0.124807616547583 0.435866157568188 no 1917 0.450337928705892 622 4779114 SGTC_918 glabranin 770.725 nM -0.125210181324897 0.435676814940324 no 1918 0.450178578573916 620 124049 Also referred to as licorice root. SGTC_1780 st038448 24.544 µM -0.125930737672486 0.435337944752338 no 1919 0.449893375606273 646 728868 YDL195W SEC31 SGTC_2915 7971052 15.16 µM -0.127317686948821 0.434685810733325 no 1920 0.449344481031754 601 5741558 SGTC_512 prima-1 270 µM -0.12778894260604 0.434464269910498 no 1921 0.449158000419668 600 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2006 4011487 200 µM -0.128252055217657 0.434246577242002 no 1922 0.44897475303292 601 45595294 SGTC_1091 telmisartan 47.6 µM -0.130470610160763 0.433203991614368 no 1923 0.448097052528469 608 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_438 sphingosine 6.67 µM -0.130504542399925 0.433188049119518 no 1924 0.448083630281751 606 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_116 0155-0182 31.788 µM -0.130731240450215 0.433081541624389 no 1925 0.447993959058642 610 771486 SGTC_2049 5262831 67.185 µM -0.130906053800644 0.432999413967448 no 1926 0.447924812828322 614 763417 SGTC_563 tetrahydrosecaminediol 614 µM -0.13149372049545 0.43272334822981 no 1927 0.447692376881607 613 334274 A psychoactive constituent of the cannabis plant. SGTC_975 1335-0046 28.5 µM -0.131725634332959 0.432614412059648 no 1928 0.447600654463318 621 16486740 SGTC_62 0180-0423 3.232 µM -0.132325751553941 0.43233254464587 no 1929 0.447363319838426 609 30102 YGL099W LSG1 SGTC_2544 sphondin 68.51 µM -0.133139534331226 0.431950376277119 no 1930 0.44704151478616 598 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_51 1013-0126 23.419 µM -0.133343368197184 0.431854661849663 no 1931 0.446960915475052 597 1627850 SGTC_3019 9081971 49.47 µM -0.134544225366364 0.431290855796559 no 1932 0.446486121095163 619 16451803 SGTC_2858 9025781 8.96 µM -0.134974729718157 0.431088766732325 no 1933 0.446315927117211 629 4894980 YPL153C RAD53 SGTC_2134 5324836 1.464 µM -0.136033994469517 0.430591599371888 no 1934 0.445897203523871 590 699272 SGTC_501 nsc-95397 161 µM -0.136356752485128 0.430440134282768 no 1935 0.445769630397873 603 262093 SGTC_2543 pimpinellin 60.67 µM -0.136490308997175 0.430377461375283 no 1936 0.445716842578221 611 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1000 4048-0884 8.67 µM -0.136566952329686 0.43034149641446 no 1937 0.445686549960343 633 13040088 SGTC_1534 6-azauridine 81.6 µM -0.136680153405317 0.430288377753049 no 1938 0.445641808789018 608 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_824 1304-0008 100 µM -0.137280928844742 0.430006490020652 no 1939 0.445404372142225 615 768245 SGTC_713 1488-1073 324 µM -0.137739300948272 0.429791442840917 no 1940 0.445223228875013 619 3312542 SGTC_305 1682-2595 20.8 µM -0.138324830616942 0.429516769465365 no 1941 0.444991851072948 633 226033 SGTC_2977 9011197 71.43 µM -0.13922799316507 0.429093160686816 no 1942 0.444634994289874 599 2704722 SGTC_2404 5161160 200 µM -0.139780772472902 0.428833931806955 no 1943 0.444416602738685 624 2831543 SGTC_2785 7756463 72.73 µM -0.140371328820806 0.42855702109414 no 1944 0.444183304913339 606 2201551 SGTC_1779 st039427 55 µM -0.140439631229366 0.428524996495171 no 1945 0.444156323461863 606 1124498 SGTC_2576 guaiol 23.12 µM -0.140552945416932 0.42847186849307 no 1946 0.444111561610518 611 227829 SGTC_1202 1988-0068 29.6 µM -0.140722824084869 0.428392222340931 no 1947 0.444044456753742 609 2850480 SGTC_1966 st070145 16.1 µM -0.141249304002117 0.428145405300851 no 1948 0.443836498759756 606 3748532 SGTC_2113 5491891 107.031 µM -0.143518385275225 0.427081968789095 no 1949 0.442940396101771 635 789979 SGTC_2425 5628681 7.85 µM -0.143718600675442 0.42698816037534 no 1950 0.442861341235791 598 5714958 SGTC_1241 0364-0022 50.8 µM -0.144931868874155 0.426419787290775 no 1951 0.442382332177445 633 4563895 SGTC_2395 5646831 180.19 µM -0.145259382585803 0.426266384880673 no 1952 0.442253041263274 636 6808628 SGTC_3093 9117344 49.47 µM -0.145451779351458 0.426176274380052 no 1953 0.442177092642411 607 24824913 SGTC_2092 5303694 80.6725 µM -0.146714780246973 0.425584834132099 no 1954 0.441678575951645 640 1963699 SGTC_2414 st077232 92.9 µM -0.14688885686444 0.425503330328085 no 1955 0.441609873724909 599 729801 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.147161298513914 0.425375777767368 no 1956 0.441502353632328 656 65057 A dermal irritant. YDR527W RBA50 SGTC_2453 5731132 22.18 µM -0.147794542543139 0.425079333846126 no 1957 0.44125245822941 644 1362040 SGTC_2664 lyso-paf C-16 73.48 µM -0.148926455525982 0.424549550987044 no 1958 0.440805832753783 609 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2088 5278280 127.392 µM -0.149108392687282 0.424464409434918 no 1959 0.440734051760107 620 791502 SGTC_2974 9094440 9.66 µM -0.14936943684984 0.424342254154655 no 1960 0.44063106350688 615 25236134 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.150263363342206 0.423923997524765 no 1961 0.440278418288001 604 756377 SGTC_533 1222-0222 6.71 µM -0.150763048397974 0.423690238660351 no 1962 0.440081318063032 639 3982874 SGTC_2690 usnic acid 100 µM -0.152068809921689 0.423079514195922 no 1963 0.439566332072101 648 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2054 5233173 129 µM -0.152071452584518 0.423078278369333 no 1964 0.439565289922129 621 6889 SGTC_594 1487-1584 10.8 µM -0.152567357343705 0.422846384674615 no 1965 0.439369734320413 640 5013332 SGTC_674 0498-0004 451 µM -0.152968894203602 0.422658638633293 no 1966 0.439211402692418 614 4231473 SGTC_2769 toremifene 3.73 µM -0.153317612507099 0.422495603143874 no 1967 0.439073906052919 618 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_224 benfluorex 43.875 µM -0.153338581742571 0.422485799866974 no 1968 0.439065638297166 614 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2982 9019404 25.97 µM -0.155619870007505 0.421419568289619 no 1969 0.438166330880203 613 22333232 SGTC_936 3005-4620 401 µM -0.157914599431618 0.420347635565804 no 1970 0.437262046864788 640 777207 SGTC_1727 st034309 9.9045 µM -0.159632525259919 0.419545530081234 no 1971 0.436585278034152 664 870305 SGTC_1152 3909-8331 15.9 µM -0.159751552737505 0.419489968082836 no 1972 0.436538394568756 624 16001939 SGTC_3080 9117754 49.47 µM -0.159888934577765 0.419425840267879 no 1973 0.436484282653048 604 9550191 SGTC_1046 2001-0062 216 µM -0.160443427477314 0.419167032934763 no 1974 0.436265891255821 616 739778 SGTC_928 2764-0428 58.7 µM -0.16326084674768 0.417852556366863 no 1975 0.435156530003688 617 662578 SGTC_1462 k081-0014 26.5 µM -0.163415863149489 0.417780259423957 no 1976 0.435095506891169 635 3270634 SGTC_1617 st002906 78 µM -0.163661526326619 0.417665692099975 no 1977 0.434998803312369 645 5150859 SGTC_302 1094-0063 18.9 µM -0.164245815598551 0.417393231417464 no 1978 0.434768817588081 632 5440289 SGTC_2332 7982454 138.89 µM -0.164248916978752 0.417391785314567 no 1979 0.434767596893401 630 2981748 SGTC_3325 9138760 55.175 µM -0.164757413905199 0.417154699911994 no 1980 0.434567462325117 628 43844959 SGTC_324 1315-0088 19.6 µM -0.166086151512884 0.416535321770474 no 1981 0.434044576142948 647 6787421 SGTC_496 calpeptin 138 µM -0.166259723925978 0.416454427940527 no 1982 0.433976280250713 619 73364 A calpain inhibitor. SGTC_1982 st072467 71.9 µM -0.166717979035272 0.416240874083757 no 1983 0.433795979151694 645 3163533 SGTC_908 3448-7491 47.7 µM -0.167098260661473 0.416063675826132 no 1984 0.433646367282712 612 1203031 SGTC_1207 2099-0101 141 µM -0.167118437266029 0.416054274693409 no 1985 0.433638429590263 617 5837381 SGTC_2670 beta-carotene 100 µM -0.167186260121005 0.416022673511226 no 1986 0.433611747548527 616 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_3316 9136639 10.545 µM -0.167244463818651 0.415995554683894 no 1987 0.433588849999758 647 4903665 SGTC_268 camptothecin 39.6153 µM -0.16738459240206 0.415930266265754 no 1988 0.433533723813974 629 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1770 st043884 66.3 µM -0.167936256303359 0.415673258731639 no 1989 0.433316713380718 618 670149 SGTC_1863 st057641 20.1 µM -0.168167533895411 0.415565522539808 no 1990 0.433225740683479 616 3921635 SGTC_894 0960-0238 55.9 µM -0.168304350672553 0.415501792078434 no 1991 0.433171925672782 634 6741907 YDL195W SEC31 SGTC_3040 9091894 49.47 µM -0.168974954621963 0.415189451022331 no 1992 0.432908170708707 613 25236966 SGTC_948 3448-0295 75.3 µM -0.169038667390678 0.415159778894553 no 1993 0.432883113418565 626 678569 SGTC_1198 1612-1005 86.7 µM -0.169939184437275 0.414740444511359 no 1994 0.432528982284214 618 6998509 SGTC_2892 9047358 58.44 µM -0.170772681363047 0.414352405236321 no 1995 0.432201255305236 640 6466771 SGTC_1373 2887-0003 58.5 µM -0.172274456626037 0.413653456355315 no 1996 0.431610882385733 616 776948 SGTC_3137 9097352 49.47 µM -0.172327454264631 0.4136287954373 no 1997 0.43159005091176 622 44120435 SGTC_180 1486-1293 102.781 µM -0.172556318133568 0.413522304169688 no 1998 0.431500094905578 653 4140536 SGTC_1513 0337-0559 19 µM -0.172926530396547 0.41335005640219 no 1999 0.431354588779944 611 775073 SGTC_1410 3909-8106 77.9 µM -0.173076600411205 0.413280238436151 no 2000 0.431295608765715 623 1039210 SGTC_165 k038-0023 64.381 µM -0.175466351158575 0.412168811428746 no 2001 0.430356604227604 623 46368543 SGTC_3217 9129673 49.47 µM -0.178584074074258 0.410719878248313 no 2002 0.429132150249861 646 17248312 SGTC_727 3032-0951 202 µM -0.178591890350393 0.410716247227332 no 2003 0.429129081338551 637 3652836 SGTC_2142 5622915 118.518 µM -0.178886129846648 0.410579564970531 no 2004 0.429013556946382 614 5322196 SGTC_1194 1488-0194 225 µM -0.179808189069309 0.410151313764463 no 2005 0.428651577227517 628 1391452 SGTC_3037 9091026 49.47 µM -0.181936938675572 0.409163024148492 no 2006 0.427816107688493 652 25236398 YIL048W NEO1 SGTC_1789 tunicamycin 25 nM -0.18276104395398 0.408780581064075 no 2007 0.427492758069711 648 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1189 1431-2119 7.28 µM -0.182900140256433 0.408716039106051 no 2008 0.427438186422286 625 3107275 SGTC_347 4534-1311 26.2 µM -0.183042798534463 0.408649846930127 no 2009 0.427382218747226 627 2862016 SGTC_275 trichlorophene 5.69 µM -0.183246228514296 0.408555461731079 no 2010 0.427302411655046 634 62616 SGTC_1555 citronellol 128 µM -0.184726778053376 0.407868692781441 no 2011 0.426721670889922 626 8842 A terpine precursor. SGTC_3044 9093193 49.47 µM -0.18614497566047 0.407211111768314 no 2012 0.426165536370027 668 25236277 SGTC_2691 st077356 60.2 µM -0.187191460977858 0.406726051510863 no 2013 0.425755259829071 649 2839272 SGTC_2953 9074162 66.49 µM -0.188556465420762 0.406093568389236 no 2014 0.425220228105589 618 16451992 SGTC_1942 st076330 65.2 µM -0.190414036665101 0.405233245283998 no 2015 0.424492349612755 683 24208414 SGTC_1218 1348-1416 30.7 µM -0.190851774399658 0.405030576134735 no 2016 0.424320862013189 635 6787668 SGTC_310 1273-0058 1.06 µM -0.192262776179438 0.404377466959885 no 2017 0.423768187355893 630 2734232 SGTC_184 1494-0393 24.714 µM -0.192869080632882 0.404096909058722 no 2018 0.4235307502213 641 3090647 SGTC_194 1486-1323 56.904 µM -0.193193812544423 0.403946664719568 no 2019 0.42340359216541 624 5178754 SGTC_923 1900-2434 73.3 µM -0.193511596204656 0.403799648858836 no 2020 0.423279162618665 644 5910570 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.194302241276618 0.40343393271735 no 2021 0.422969615397096 618 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.195009881675739 0.403106682317495 no 2022 0.42269260583954 656 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_3106 9121286 49.47 µM -0.196056215631616 0.40262292647633 no 2023 0.42228308299035 618 15943471 SGTC_2991 9074669 71.4286 µM -0.197989432683235 0.401729526989746 no 2024 0.421526665786549 653 17333109 SGTC_3313 9133968 57.047 µM -0.198318655091215 0.401577434141952 no 2025 0.42139787845074 634 1494643 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.198476926143271 0.401504322020842 no 2026 0.42133596795613 630 5106787 A p450 inhibitor. SGTC_105 0111-0055 734.78 µM -0.199749350016195 0.400916660884892 no 2027 0.420838307861566 663 5179370 SGTC_1014 4130-3005 69.3 µM -0.199782587667499 0.400901313278313 no 2028 0.420825309912844 650 743608 SGTC_247 mechlorethamine 29.705 µM -0.200801388638267 0.400430952522791 no 2029 0.420426938534755 630 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2418 pentamidine 31.67 µM -0.200926081138001 0.400373394303026 no 2030 0.420378186884388 653 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1912 st060209 90.8 µM -0.201548158963986 0.400086274716563 no 2031 0.420134988265987 669 688787 SGTC_2266 7929956 200 µM -0.202231127518012 0.399771113247847 no 2032 0.419868019798619 628 2967153 SGTC_3215 9129942 49.47 µM -0.203078516174325 0.399380169538902 no 2033 0.419536831728617 649 17682944 SGTC_1353 1498-1206 8.11 µM -0.203305201173096 0.399275605246208 no 2034 0.419448245236909 639 6756808 SGTC_1160 4092-0570 10.5 µM -0.203549075939024 0.399163119799558 no 2035 0.419352945695058 625 4994975 SGTC_2610 ononetin 44.17 µM -0.204585665627011 0.398685093941226 no 2036 0.418947927846858 660 259632 SGTC_3263 9137018 49.47 µM -0.20471640821294 0.398624812455993 no 2037 0.418896850001946 627 43844957 SGTC_1753 st043925 64 µM -0.20555677457215 0.398237402523574 no 2038 0.418568572640009 651 670181 SGTC_1327 1436-0082 2.18 µM -0.205666607125233 0.398186776982687 no 2039 0.418525672274586 645 15992205 SGTC_1806 st050005 60.3 µM -0.205756142764617 0.398145508244233 no 2040 0.418490700558149 640 5194765 SGTC_888 0916-0002 6.97 µM -0.20803479895441 0.397095615440577 no 2041 0.417600898038983 637 2802138 YIL048W NEO1 SGTC_87 0100-0052 35.5 µM -0.209374003109252 0.396478923193985 no 2042 0.417078142761418 640 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_67 0335-0847 266 µM -0.209954272053724 0.396211794525582 no 2043 0.416851681562845 702 4552207 YOR254C SEC63 SGTC_652 0437-0092 114 µM -0.21014667049218 0.396123234037237 no 2044 0.416776600430974 633 3091274 SGTC_414 piperonyl butoxide 100 µM -0.210525710479874 0.395948778628702 no 2045 0.416628693606298 650 5794 A potent inhibitor of cytochrome P450. SGTC_1496 4469-0713 57.4 µM -0.210764613374908 0.395838832854837 no 2046 0.416535476341901 672 746691 SGTC_978 1416-0512 87.4 µM -0.210878246267938 0.395786540639167 no 2047 0.416491139692099 646 6814003 SGTC_3260 9137109 49.47 µM -0.21189367437367 0.395319338670185 no 2048 0.416094992834415 638 17478346 SGTC_1824 st053723 68.6 µM -0.212472335965602 0.395053161720917 no 2049 0.415869278887391 669 675225 SGTC_2812 7970281 58.44 µM -0.212618882071663 0.394985760147838 no 2050 0.415812121208554 664 2233435 SGTC_1205 4161-2785 76 µM -0.214360258483476 0.394185082555706 no 2051 0.415133065228733 688 3498106 SGTC_1907 st060210 83.7 µM -0.215538794057459 0.393643450221564 no 2052 0.414673634732907 660 688793 SGTC_600 1495-0418 41.6 µM -0.215699916819574 0.393569417253511 no 2053 0.414610833030307 647 5377768 SGTC_2826 7992541 19.48 µM -0.217810290344341 0.392600095299254 no 2054 0.413788463257443 669 2985066 SGTC_3182 9108849 49.47 µM -0.219422156174171 0.391860192519951 no 2055 0.413160606200225 636 17133045 SGTC_2342 7990637 118.86 µM -0.220406313473134 0.391408621945005 no 2056 0.412777364433785 690 2033102 YER133W GLC7 SGTC_1668 st014914 51.6 µM -0.221572041308236 0.39087392890323 no 2057 0.412323524654468 623 2839556 SGTC_2007 4011539 71.82 µM -0.222131268274289 0.390617497255133 no 2058 0.412105848639309 617 45595301 SGTC_2606 farnesol 9.78 µM -0.2224183633288 0.390485869252571 no 2059 0.411994108970735 633 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2856 9022925 19.48 µM -0.222468173010571 0.39046303367204 no 2060 0.41197472337425 650 4944862 SGTC_2757 clomiphene 4.22 µM -0.224135893256049 0.389698674796687 no 2061 0.411325782046846 648 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_849 0386-0493 241 µM -0.224907749953059 0.389345057282579 no 2062 0.411025520077071 644 726119 SGTC_123 0083-0120 66.675 µM -0.22492535958992 0.389336990692191 no 2063 0.411018670314164 648 16001701 SGTC_2021 4019055 173 µM -0.225928542420514 0.388877533367273 no 2064 0.410628499032304 658 44827708 YER133W GLC7 SGTC_3244 9134489 49.47 µM -0.226963260108501 0.388403795867171 no 2065 0.410226155430405 683 16584271 SGTC_2456 5770359 74.46 µM -0.228604358869522 0.387652772078183 no 2066 0.409588218195136 647 3118787 SGTC_2198 6589944 200 µM -0.229762634967906 0.38712295744585 no 2067 0.409138110474709 652 5290268 SGTC_3304 9125678 46.087 µM -0.230268394323609 0.386891680634736 no 2068 0.408941609210924 649 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_476 mead acid 10 µM -0.230406409825836 0.386828575010959 no 2069 0.408887990407299 648 5312531 An omega 9 fatty acid. SGTC_3094 9117742 49.47 µM -0.230856257676325 0.386622909261402 no 2070 0.408713237071776 645 17149698 SGTC_2976 9009005 19.48 µM -0.231698002404309 0.386238157914074 no 2071 0.408386291510333 630 2993148 SGTC_2440 5628896 157.78 µM -0.232354615016027 0.38593810584802 no 2072 0.408131298136889 644 5522048 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.232912227142001 0.385683347564584 no 2073 0.407914781821109 695 6728940 SGTC_195 4234-0266 16.654 µM -0.233088453552285 0.385602844610648 no 2074 0.407846360363946 660 2303354 SGTC_2380 9035439 200 µM -0.233603544060337 0.385367571550659 no 2075 0.407646388053783 650 6462575 SGTC_3053 9095903 49.47 µM -0.23363558600346 0.385352937445544 no 2076 0.407633949284088 667 17174018 SGTC_2154 5570129 200 µM -0.233681487709072 0.385331973633563 no 2077 0.40761613027905 660 673366 SGTC_2926 9010726 65.15 µM -0.234912318182255 0.384769965002514 no 2078 0.40713839427375 692 2994293 SGTC_3113 9123498 49.47 µM -0.235578581844483 0.38446584371724 no 2079 0.406879847474312 640 8897275 SGTC_166 k072-0058 166.424 µM -0.23647241319426 0.384057959069067 no 2080 0.406533055699162 644 5846229 SGTC_3174 9107204 49.47 µM -0.237419651525749 0.383625843180959 no 2081 0.406165622896548 668 3938802 SGTC_2228 7354201 200 µM -0.237535662175676 0.383572930801092 no 2082 0.406120628154296 654 753451 SGTC_2005 4024620 188 µM -0.238602164982411 0.383086601426314 no 2083 0.405707043099577 663 236743 SGTC_1920 st075728 45.7 µM -0.239886870932039 0.382501015241611 no 2084 0.405208979603806 651 3400306 SGTC_289 k017-0060 526 µM -0.240147434758051 0.3823822794753 no 2085 0.405107981151607 652 5512909 SGTC_2732 terfenadine 20 µM -0.240756665950309 0.382104703401276 no 2086 0.404871858665415 653 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_351 caspofungin 25 nM -0.240843780079485 0.382065017672784 no 2087 0.40483809827678 639 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_629 3448-6466 76.7 µM -0.246421621337619 0.379526572032779 no 2088 0.402677935386096 687 573744 SGTC_1631 benzylvanillin 81.9 µM -0.248857802759035 0.378419498911264 no 2089 0.401735388539815 658 75506 SGTC_11 0438-0307 1.3 µM -0.250219537374178 0.377801120174016 no 2090 0.401208788544188 663 4011476 SGTC_745 0469-0705 296 µM -0.251337262496182 0.377293782672188 no 2091 0.400776684123871 674 3486736 SGTC_1831 st055328 12 µM -0.252582020191861 0.376729034035 no 2092 0.400295612702667 682 1103068 SGTC_423 5-fluorouracil 457 µM -0.252821658110408 0.376620340144905 no 2093 0.400203015265375 649 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1254 0550-0035 264 µM -0.252823418166267 0.37661954186285 no 2094 0.400202335190655 682 15121435 SGTC_2730 imipramine 71.33 µM -0.252924160440434 0.376573850584728 no 2095 0.400163409502195 664 3696 A tricyclic antidepressant. SGTC_2780 5215298 71.43 µM -0.255258450126616 0.375515627751068 no 2096 0.399261744569434 695 2834131 SGTC_1984 st072354 53.1 µM -0.255436975929379 0.375434733599705 no 2097 0.399192807546112 660 5762938 SGTC_2777 climbazole 1.536 µM -0.255860949840399 0.375242643213048 no 2098 0.399029104320858 651 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2375 9072683 200 µM -0.256370741725962 0.375011712132026 no 2099 0.398832288894333 676 16798029 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.258181224431486 0.374191942551367 no 2100 0.398133523783076 645 368090 SGTC_2966 9084041 48.03 µM -0.261202813378251 0.372825063213707 no 2101 0.396968054325145 662 17741380 SGTC_1813 st051246 8.6015 µM -0.26131789982013 0.372773032957551 no 2102 0.396923681976649 653 5291959 SGTC_403 arphamenine a 50 µM -0.261635413380619 0.372629498009391 no 2103 0.396801269417831 684 5487158 An arginine aminopeptidase inhibitor. SGTC_92 0063-0024 660.874 µM -0.262842516270453 0.372083977540854 no 2104 0.396335982038548 663 3594437 SGTC_2900 5328528 85.29 µM -0.262861131827004 0.372075566704548 no 2105 0.396328807678749 638 795359 SGTC_1106 tegaserod maleate 11.7 µM -0.265062911187426 0.371081195576454 no 2106 0.395480499136072 673 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2155 5570423 76 µM -0.265214517994859 0.371012758243792 no 2107 0.395422105753398 688 797402 SGTC_1120 ficusin 1.78878 µM -0.266558615520214 0.370406193350201 no 2108 0.394904511497472 671 6199 A DNA cross-linker. SGTC_3001 9076041 71.4286 µM -0.266984293248676 0.370214160406157 no 2109 0.394740627227247 668 16004211 SGTC_1408 3909-7976 48.8 µM -0.267012662070397 0.37020136373198 no 2110 0.394729706002847 660 24152374 SGTC_3200 9114385 49.47 µM -0.267350234516914 0.370049101796496 no 2111 0.394599756148161 677 17018030 YLR208W SEC13 SGTC_2539 epi(13)torulosol 80 µM -0.268081632553966 0.369719274855716 no 2112 0.394318241816666 696 6708597 SGTC_595 3909-8003 73.7 µM -0.269412781020325 0.369119234064408 no 2113 0.393806025912045 693 699517 SGTC_860 0443-0016 25.1 µM -0.269509844505928 0.369075493282714 no 2114 0.393768683787938 665 5337942 SGTC_1388 3346-4487 254 µM -0.269891880982399 0.368903348473785 no 2115 0.393621716757974 690 3345614 SGTC_2917 7979103 53.79 µM -0.270285720329075 0.368725912843887 no 2116 0.393470225100497 694 2980565 SGTC_1818 st052136 56.3 µM -0.271010227570503 0.36839957519385 no 2117 0.393191583034555 656 674169 SGTC_1526 st051518 75 µM -0.271787520520797 0.368049566967917 no 2118 0.392892700667197 665 673993 SGTC_1259 0671-0132 43 µM -0.271878424225776 0.368008640970596 no 2119 0.392857750765946 664 X1259 SGTC_798 1287-0182 476 µM -0.272426780498337 0.367761795834855 no 2120 0.392646941632384 689 1649755 SGTC_2438 5259590 200 µM -0.272637051948605 0.367667155639806 no 2121 0.392566113590468 681 1201127 SGTC_2568 diosmetin 100 µM -0.272961371868298 0.367521199603331 no 2122 0.392441454567619 673 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2864 9034755 47.6 µM -0.273053679241706 0.367479661346349 no 2123 0.392405976349448 652 4930451 SGTC_1449 4112-4002 201 µM -0.273576679288767 0.367244340962969 no 2124 0.392204978860198 651 2059539 SGTC_2558 carylophyllene oxide 100 µM -0.273977266535286 0.367064133115064 no 2125 0.392051046061984 677 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1676 st018489 23.4 µM -0.27420673798952 0.366960916466077 no 2126 0.391962875169509 662 3696235 SGTC_290 2043-6722 48.1 µM -0.274369066868761 0.366887906468075 no 2127 0.391900506133453 676 773758 YLR208W SEC13 SGTC_1702 st027038 51 µM -0.277031734356336 0.365691018332441 no 2128 0.390877869452217 678 5521182 SGTC_1707 st032323 6.317 µM -0.278577254769404 0.364996894205897 no 2129 0.390284635006681 673 3132057 YMR211W DML1 SGTC_2162 5663267 200 µM -0.278739574882535 0.364924018616319 no 2130 0.390222344651445 711 6456493 SGTC_2750 bromebric acid 70.15 µM -0.278942892737151 0.364832743475617 no 2131 0.390144325385995 697 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_417 st075190 100 µM -0.279006429897118 0.364804221416501 no 2132 0.390119945146026 688 222757 SGTC_2818 7996756 12.99 µM -0.280027323870655 0.364346041139541 no 2133 0.38972827087559 646 2241621 SGTC_1815 st051655 58.2 µM -0.280071457938591 0.364326238002473 no 2134 0.389711341003586 661 5984156 SGTC_3011 9081274 71.4286 µM -0.280331805997985 0.364209426133077 no 2135 0.389611475490405 656 6625322 SGTC_1134 3477-0009 42.5 µM -0.280704423820939 0.364042263486309 no 2136 0.389468557703796 672 3973534 SGTC_348 k064-0012 10.7 µM -0.281473115902543 0.363697496990915 no 2137 0.38917377264659 668 5066323 SGTC_2526 patulin 37.61 µM -0.282010423759641 0.363456574256833 no 2138 0.388967758783266 676 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2799 7812892 81.82 µM -0.282157242256337 0.363390751901231 no 2139 0.388911471258305 673 20205235 SGTC_585 0kpi-0023 191 µM -0.282389500982907 0.363286632819501 no 2140 0.388822432275081 694 64601 SGTC_3166 9102297 49.47 µM -0.282968507248355 0.363027114547492 no 2141 0.388600489175033 681 25237072 SGTC_1812 st052057 4.327 µM -0.283168878492186 0.362937320143811 no 2142 0.388523691882361 664 3645418 SGTC_1975 st070967 30.8 µM -0.283331487033896 0.362864454262428 no 2143 0.388461371292874 686 261391 SGTC_710 3448-4187 58 µM -0.285139228532829 0.362054729199105 no 2144 0.387768738466436 655 3946412 SGTC_2019 4016004 108 µM -0.285896205458277 0.361715846532013 no 2145 0.387478810055719 677 45595336 SGTC_2051 5263410 176 µM -0.286097954488807 0.361625546017397 no 2146 0.387401549094216 651 227584 SGTC_2082 5219693 150 µM -0.286279520038333 0.36154428598139 no 2147 0.387332021326255 689 2834649 SGTC_515 4092-1064 102 µM -0.286593385849728 0.361403829419454 no 2148 0.387211839707942 724 717353 SGTC_667 1498-1044 59 µM -0.286614318654062 0.361394462546216 no 2149 0.387203824761558 679 6739982 SGTC_2517 totarol 10 µM -0.28942147911739 0.360139087576033 no 2150 0.386129430020099 678 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1495 4469-0029 237 µM -0.290078325905783 0.359845559725162 no 2151 0.385878158341201 685 793680 SGTC_2283 7944793 200 µM -0.290927524805862 0.359466197189282 no 2152 0.385553374811144 646 2970533 SGTC_1418 3966-3099 2.4 µM -0.292745706996223 0.358654426873281 no 2153 0.38485826521875 677 740335 SGTC_556 4058-0063 51.5 µM -0.293432897955503 0.358347780235319 no 2154 0.38459564131265 694 6615692 SGTC_837 0091-0265 12.5 µM -0.294499106606229 0.35787218458889 no 2155 0.384188272993922 675 759367 SGTC_3054 9094397 49.47 µM -0.294617848076484 0.357819232111894 no 2156 0.384142913126851 697 2598354 SGTC_3198 9112019 49.47 µM -0.294897055789091 0.357694730876674 no 2157 0.38403626056342 716 45595555 SGTC_3101 9120531 49.47 µM -0.295242343484734 0.357540784920572 no 2158 0.383904378723658 731 24824904 SGTC_2584 androsterone 48.74 µM -0.295633103760671 0.357366593045029 no 2159 0.383755144953506 689 2754130 A steroid. SGTC_52 0329-0193 875 nM -0.297083783022669 0.356720174037021 no 2160 0.383201272514574 713 3739292 SGTC_1376 2910-0861 41.3 µM -0.297493623308394 0.356537624669569 no 2161 0.383044837808288 670 1112859 SGTC_2904 7225135 42.03 µM -0.298345536798888 0.356158274066169 no 2162 0.382719726248003 695 4446116 SGTC_2702 st077768 96.8 µM -0.298473411218107 0.356101344835254 no 2163 0.382670933287934 659 6484119 SGTC_499 genistein 192 µM -0.298515554541494 0.356082583482182 no 2164 0.382654853095046 682 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_684 1140-0066 328 µM -0.299237638839478 0.355761180360697 no 2165 0.382379366292094 695 6813534 SGTC_1655 st012546 55.1 µM -0.301376678308004 0.354809686172957 no 2166 0.381563638052836 689 720985 YLR208W SEC13 SGTC_676 falcarinol 140 µM -0.302500331600033 0.354310221385078 no 2167 0.381135340353745 716 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_505 gw-5074 63.9 µM -0.303338271597814 0.35393791937341 no 2168 0.380816041380265 678 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1 0258-0098 57.368 µM -0.304274054475499 0.353522310178588 no 2169 0.380459555075749 653 6790032 YDR047W HEM12 SGTC_1568 digitonin 820 nM -0.304933861635776 0.353229374965969 no 2170 0.380208262657083 716 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.306141789153632 0.352693315614668 no 2171 0.379748345626359 677 279621 SGTC_955 1216-0110 33 µM -0.306229437910729 0.35265442983035 no 2172 0.37971498007129 657 3619719 SGTC_1710 st031758 61.5 µM -0.306272503998255 0.352635323921617 no 2173 0.379698586283116 688 5394341 SGTC_2592 piperlongumine 83.33 µM -0.30740723270372 0.352132045105433 no 2174 0.379266711824431 685 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1921 5740136 50 µM -0.307719558978658 0.351993566467622 no 2175 0.379147867761735 713 1774243 SGTC_1453 4237-0541 195 µM -0.3086056871479 0.35160078351673 no 2176 0.378810747091982 667 739892 SGTC_508 roscovitine 141 µM -0.308845561272152 0.351494484735629 no 2177 0.378719504663583 685 160355 A CDKinase inhibitor. SGTC_226 1,3-diallylurea 8.28947 mM -0.309000973419675 0.351425620972052 no 2178 0.378660393176193 688 74537 YKL182W FAS1 SGTC_2617 dihydrotanshinone i 20.83 µM -0.310002100006983 0.350982134624164 no 2179 0.37827967970024 649 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1022 4477-0945 21.3 µM -0.311124152471523 0.350485320814739 no 2180 0.377853120340274 669 4648966 SGTC_451 chloral hydrate 100 µM -0.31172524683512 0.350219277955126 no 2181 0.377624669575742 707 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2534 helenine 20.12 µM -0.315051960028182 0.348748214894313 no 2182 0.376361101367417 659 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_598 3937-0236 20.2 µM -0.315134499623026 0.348711744904895 no 2183 0.376329767557284 687 1379313 SGTC_2323 6148992 148.28 µM -0.3155719696778 0.348518472800466 no 2184 0.376163708102507 675 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_843 0310-0051 143 µM -0.315850821150963 0.34839529811451 no 2185 0.376057870707484 687 2065037 SGTC_2326 6164455 177.58 µM -0.316340203277718 0.348179166168362 no 2186 0.375872149456126 689 2888790 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.316406388376313 0.348149939798976 no 2187 0.375847034318015 687 688801 SGTC_3175 9106517 49.47 µM -0.31736749153623 0.347725632444758 no 2188 0.3754823855848 694 41468073 SGTC_2026 5148700 152 µM -0.317479307084681 0.347676280542141 no 2189 0.375439969260977 666 79838 SGTC_989 1501-0895 10.3 µM -0.319020898690617 0.346996133423965 no 2190 0.374855332644471 701 2830112 SGTC_605 1315-0399 119 µM -0.320773965470249 0.346223282565289 no 2191 0.374190845091204 688 24020461 SGTC_729 4092-0585 94.1 µM -0.320784192897429 0.346218775612265 no 2192 0.374186969551589 678 2169061 SGTC_3000 9075062 71.4286 µM -0.321062842401092 0.346095990626649 no 2193 0.374081384136758 656 17057871 SGTC_382 3229-0966 23.2 µM -0.321239437311677 0.346018183669464 no 2194 0.374014473971197 720 5722370 SGTC_138 0850-0259 40.9225 µM -0.321569306105417 0.345872862314039 no 2195 0.373889499928373 692 6813004 SGTC_1642 st009582 77.7 µM -0.321576121718391 0.345869859983426 no 2196 0.373886917905974 716 6739311 SGTC_2014 4013930 200 µM -0.322849376510672 0.345309151526223 no 2197 0.373404658281999 717 64556 SGTC_1438 4092-1045 4 µM -0.323015773849479 0.345235899490876 no 2198 0.373341648040465 684 1351342 SGTC_1731 st035964 63 µM -0.323400671778813 0.345066480558651 no 2199 0.373195910423017 724 6739575 SGTC_792 4534-1957 155 µM -0.323730897591072 0.344921151173167 no 2200 0.373070888293941 674 1717904 SGTC_970 1315-0089 19.5 µM -0.324308614884071 0.344666958057608 no 2201 0.372852199062024 661 6811083 YLR033W RSC58 SGTC_3356 9151811 4.48 µM -0.325175634349331 0.344285604836034 no 2202 0.372524074222974 681 1859254 YPR165W RHO1 SGTC_525 k781-2675 26.7 µM -0.325716233047991 0.344047905876639 no 2203 0.372319530623186 659 3651118 YDL195W SEC31 SGTC_1955 wogonin 32.4 µM -0.326051898914073 0.343900346014381 no 2204 0.372192544543795 677 5281703 A flavanone. SGTC_2842 9000675 19.48 µM -0.32633329890724 0.343776659932909 no 2205 0.372086098547611 659 2989072 SGTC_2417 cerulenin 830 nM -0.326716695970671 0.343608169139863 no 2206 0.371941085554561 710 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_764 1951-2361 146 µM -0.329516314116222 0.342378769698288 no 2207 0.37088273249101 698 5438930 SGTC_2250 alverine citrate 130 µM -0.330535749946942 0.341931517356517 no 2208 0.370497592268064 685 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_714 4296-0578 26.1 µM -0.331642531943615 0.341446195076367 no 2209 0.370079599808351 682 1589775 SGTC_1604 st002052 72.4 µM -0.331934215336991 0.341318335937047 no 2210 0.369969466817204 668 6254834 YHR062C RPP1 SGTC_3354 9151612 71.43 µM -0.332428608463492 0.341101660781736 no 2211 0.369782819614972 713 27261949 SGTC_1225 1216-0074 20.6 µM -0.332484261537259 0.341077273272074 no 2212 0.369761810946515 691 4241466 SGTC_3236 9132701 49.47 µM -0.332516297745282 0.341063235115261 no 2213 0.369749717665472 716 24282524 SGTC_1282 0886-0010 32.4 µM -0.333260128881798 0.340737352748629 no 2214 0.369468966651003 681 2836211 YNL267W PIK1 SGTC_1067 clotrimazole 1.36 µM -0.333808637920273 0.340497119709524 no 2215 0.369261982417997 675 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1133 3473-0247 50 µM -0.334842593876913 0.340044449234937 no 2216 0.368871914030018 707 711311 SGTC_3136 9095672 49.47 µM -0.335765405173432 0.339640633003738 no 2217 0.368523889899812 651 17217380 SGTC_616 4092-0450 108 µM -0.335878602072732 0.339591111436278 no 2218 0.368481206843606 691 787165 SGTC_852 0418-0143 439 µM -0.336253519841207 0.339427111567449 no 2219 0.368339848518318 709 5369229 SGTC_1371 2421-0008 32.7 µM -0.337124642919726 0.339046174597011 no 2220 0.368011470662756 704 2827552 SGTC_2654 protoveratrine a 100 µM -0.33762423139265 0.338827781708151 no 2221 0.367823189685392 706 5702278 A heart drug and vasodilator. SGTC_163 TUB2.036 7.546 µM -0.337951024576184 0.338684954814396 no 2222 0.367700047615747 678 15992207 YJR013W GPI14 SGTC_213 1246-0773 967 nM -0.337994211479084 0.338666081457789 no 2223 0.367683774962286 699 6251622 SGTC_2287 7945887 168.79 µM -0.33818267448711 0.338583724897592 no 2224 0.36761276562982 684 1245853 SGTC_2170 morpholine 200 µM -0.339707011899484 0.337917887779111 no 2225 0.367038590365256 697 121171 Reacts with secondary amines. SGTC_2475 5812728 15.03 µM -0.340064110642649 0.337761978712461 no 2226 0.366904124187658 694 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2572 astragaloside iv 100 µM -0.342498452249602 0.336699889662122 no 2227 0.365987904285453 688 45006101 An anti-inflammatory agent. SGTC_2429 5902844 64.44 µM -0.343121170166229 0.336428410121648 no 2228 0.36575365267333 710 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_982 1491-0518 27.5 µM -0.343410371091367 0.336302359329045 no 2229 0.365644879203816 678 3091256 SGTC_2878 9043973 25.97 µM -0.343444883738749 0.336287317913693 no 2230 0.365631899121581 690 6465167 SGTC_54 0159-0055 9 µM -0.34380642225883 0.336129766763309 no 2231 0.365495935038011 752 3319099 SGTC_1956 st077085 54 µM -0.343824935617698 0.336121699791633 no 2232 0.365488973158875 701 24208685 SGTC_2662 daunorubicin 22.37 µM -0.34501041773412 0.335605297620657 no 2233 0.365043269420614 679 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1025 k007-0731 70 µM -0.345148069201705 0.335545356017458 no 2234 0.364991528626893 670 6256118 SGTC_854 0422-0053 192 µM -0.345530144938137 0.335378999542569 no 2235 0.364847925883065 686 3596728 SGTC_2837 9008476 45.46 µM -0.347121759160749 0.334686355346874 no 2236 0.364249923609476 737 2992805 SGTC_317 4495-0002 170 µM -0.347203319880049 0.334650876592137 no 2237 0.364219288451065 714 15991618 SGTC_3245 9134821 49.47 µM -0.347682276987712 0.33444256097674 no 2238 0.36403940408079 710 17014901 SGTC_399 oxolinic acid 75 µM -0.347682913907857 0.334442283991256 no 2239 0.364039164889368 683 4628 A DNA gyrase inhibitor. SGTC_3338 9144300 39.5675 µM -0.347900726974017 0.334347566166554 no 2240 0.363957369646185 703 4901274 SGTC_1375 2910-0797 186 µM -0.348315029346268 0.334167432441206 no 2241 0.363801803971439 712 742508 SGTC_649 1123-0311 367 µM -0.348473642512711 0.334098479436779 no 2242 0.363742252531155 720 693629 YIL048W NEO1 SGTC_2712 st079126 47.7 µM -0.348793913750205 0.333959266803427 no 2243 0.36362201647305 705 3152970 SGTC_1640 st009078 66.4 µM -0.348901031842662 0.333912710767765 no 2244 0.363581805252275 719 690618 SGTC_2680 butyl paraben 22.24 µM -0.349735465490839 0.333550133893685 no 2245 0.363268617439637 701 7184 An antifungal and steroid mimetic. SGTC_1762 st045503 25.4615 µM -0.349818233094476 0.333514178304325 no 2246 0.363237557270326 707 4645554 SGTC_958 1222-0007 33 µM -0.350375362279197 0.333272192158719 no 2247 0.363028507007699 723 7312461 SGTC_599 1935-0052 86.5 µM -0.350478470774355 0.333227415129201 no 2248 0.362989822324474 703 9557311 SGTC_252 miconazole 1.30953 nM -0.350767491703418 0.333101914391828 no 2249 0.362881393676895 708 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2933 9026794 32.47 µM -0.351407335929021 0.332824143150276 no 2250 0.362641389814866 724 17586027 SGTC_208 k072-0098 12.366 µM -0.351676877653003 0.332707156277571 no 2251 0.362540301581207 722 5948901 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.352036637641451 0.332551038127284 no 2252 0.362405393052525 669 115019 SGTC_2390 9097792 176.6 µM -0.35372005565564 0.331820903689921 no 2253 0.361774345426061 687 4497149 SGTC_168 3970-0862 530.542 µM -0.353761230138066 0.331803053421406 no 2254 0.361758915421663 689 3135186 SGTC_562 3772-2733 112 µM -0.353868498515114 0.331756551428324 no 2255 0.361718717999103 713 2876874 YIL048W NEO1 SGTC_3306 9127676 59.7925 µM -0.354197866052998 0.3316137832665 no 2256 0.361595301355276 677 41905287 SGTC_624 k048-0052 28 µM -0.358241705049947 0.329862933501846 no 2257 0.360081219693039 685 6835531 SGTC_1872 amphotericin b 148 nM -0.358605625549944 0.329705549796831 no 2258 0.359945068887284 705 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1561 5-methoxyflavone 52.9 µM -0.360523948050126 0.328876436993153 no 2259 0.359227675533577 698 94525 SGTC_2225 6654152 15.4 µM -0.360897756463396 0.328714972128371 no 2260 0.359087940403247 715 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2172 5754775 163.918 µM -0.362456939441118 0.328041835104246 no 2261 0.358505298155621 691 2263357 SGTC_2830 7992007 71.43 µM -0.363457900052185 0.32760999019536 no 2262 0.358131428278317 702 1952075 SGTC_311 1315-0136 58 µM -0.364060889907457 0.32734995321312 no 2263 0.357906270503526 712 6759207 SGTC_1840 st055363 71 µM -0.366040906339136 0.326496668598677 no 2264 0.357167275863004 717 676033 SGTC_1357 1503-1303 39.5 µM -0.367276605037204 0.32596460575419 no 2265 0.356706351514421 687 292895 SGTC_2623 humulene 100 µM -0.369493935459706 0.325010763808972 no 2266 0.355879796337346 714 6187145 An anti-inflammatory. SGTC_361 000s-0510 1.45 µM -0.370312200032642 0.32465905527121 no 2267 0.355574942321317 702 660 SGTC_298 1391-0729 10 µM -0.370484120700578 0.324585179754701 no 2268 0.355510903005485 699 3237558 SGTC_720 r052-1644 49.9 µM -0.370912528725659 0.324401119852446 no 2269 0.355351341588543 727 1422863 YOR257W CDC31 SGTC_3046 9092212 49.47 µM -0.370988262910093 0.32436858611133 no 2270 0.355323136877994 679 25236637 SGTC_158 k038-0087 26.446 µM -0.371251998803552 0.324255301432421 no 2271 0.355224923288922 676 X158 SGTC_552 k242-0005 476 µM -0.371938754715661 0.32396038978435 no 2272 0.354969224838636 743 4088318 SGTC_2200 6600604 21.907 µM -0.372192593044921 0.323851412658385 no 2273 0.354874730247422 735 2904777 SGTC_1804 st050076 49.1 µM -0.372634622722687 0.323661677817271 no 2274 0.354710200311292 706 3895976 SGTC_2552 juarezic acid 87.02 µM -0.373331441541821 0.323362671499693 no 2275 0.354450889156272 699 1549512 SGTC_1465 k213-0056 144 µM -0.375951683017858 0.322239342780736 no 2276 0.353476408343237 718 24048857 YMR208W ERG12 SGTC_931 2812-0076 566 µM -0.376561165298871 0.321978282559696 no 2277 0.35324987619214 695 3450959 SGTC_1883 5-benzylidenerhodanine 20 µM -0.376914708754277 0.321826889140432 no 2278 0.353118495108899 709 1273210 SGTC_3079 9117512 49.47 µM -0.377336222899987 0.321646428145755 no 2279 0.352961878162973 731 7185044 SGTC_698 k064-0052 127 µM -0.379544432674869 0.320701725386071 no 2280 0.352141807786539 719 5088751 SGTC_2694 st077685 81.9 µM -0.380096412949879 0.320465761563229 no 2281 0.351936924191025 678 2838096 SGTC_1258 0671-0043 57.1 µM -0.380838127323204 0.320148803332876 no 2282 0.351661682936346 740 4298767 SGTC_3020 9089140 49.47 µM -0.382529549719211 0.319426495564831 no 2283 0.351034307466408 695 17217859 SGTC_3123 9126162 49.47 µM -0.383267381885825 0.319111624818789 no 2284 0.350760760805996 674 25239884 SGTC_1932 st074806 40.9 µM -0.383281845533629 0.319105453743109 no 2285 0.350755399271581 715 17251235 SGTC_2817 7995342 71.43 µM -0.383292626464676 0.319100853971969 no 2286 0.350751402904 744 18879975 SGTC_675 1309-0189 238 µM -0.38761695144848 0.317258098406186 no 2287 0.349149761211003 698 4246530 SGTC_913 3487-1245 167 µM -0.388430536348361 0.316911903620093 no 2288 0.348848725013386 697 4016153 SGTC_6 0844-0013 19.835 µM -0.390503162189681 0.31603068920927 no 2289 0.348082258732479 725 1584900 SGTC_2073 5212005 126 µM -0.39122620783532 0.315723518678173 no 2290 0.34781501898098 738 691789 SGTC_1934 st074720 32.6 µM -0.39162427702477 0.315554461762033 no 2291 0.347667923716582 702 17250992 SGTC_315 k915-0449 187 µM -0.392243067917841 0.315291742675925 no 2292 0.347439312491673 710 20970215 YNL149C PGA2 SGTC_3041 9091929 49.47 µM -0.392590688716379 0.315144194806547 no 2293 0.347310908922825 708 25236887 SGTC_3116 9124943 49.47 µM -0.393453445579879 0.31477812455049 no 2294 0.346992301025339 693 41905195 YPL160W CDC60 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.394758833106627 0.314224590775993 no 2295 0.346510439484398 711 16623 A steroid. SGTC_1741 st038134 10.228 µM -0.395745518172297 0.313806475918726 no 2296 0.346146386216428 736 1272587 SGTC_1237 0330-0133 46.1 µM -0.396333401140662 0.313557469885729 no 2297 0.345929544922289 740 X1237 YHR072W ERG7 SGTC_1396 3511-0007 98.6 µM -0.396740461410053 0.313385103586459 no 2298 0.345779429880026 724 X1396 SGTC_314 1671-0008 2.74 µM -0.396895760496234 0.313319354212015 no 2299 0.345722165315901 750 3913060 SGTC_2206 7254556 146.969 µM -0.400477945431167 0.311804405623033 no 2300 0.344402262189235 702 4398905 SGTC_2760 etidronate 98.04 µM -0.400496357090683 0.311796627303863 no 2301 0.344395483046723 707 3305 A chelator and antioxidant. SGTC_154 3389-1638 511.116 µM -0.400761976222506 0.311684421320706 no 2302 0.34429768808621 769 5238686 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.401177786350468 0.311508804982214 no 2303 0.344144617100789 715 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3232 9132874 49.47 µM -0.401270160214397 0.311469796937211 no 2304 0.344110615241474 730 3784940 SGTC_1546 5-methoxyflavanone 78.7 µM -0.402048207046245 0.31114132388379 no 2305 0.343824274325941 706 147795 SGTC_1898 st060199 18.6 µM -0.402596419291678 0.310909971857048 no 2306 0.343622572125251 697 688866 SGTC_2482 5981709 142.65 µM -0.402692437328163 0.310869458801499 no 2307 0.34358724905663 734 877755 SGTC_2782 7736369 71.43 µM -0.40323784570712 0.31063937721124 no 2308 0.343386630407687 715 2950836 YOL077C BRX1 SGTC_2062 5245942 200 µM -0.405010525579693 0.309892080526812 no 2309 0.342734887017331 709 1376160 SGTC_320 4092-0846 5.34 µM -0.405494929366946 0.309688010094723 no 2310 0.342556872447104 709 1359356 SGTC_1602 st001878 87.6 µM -0.405594466872965 0.309646084030585 no 2311 0.342520297528062 762 595405 YLR310C CDC25 SGTC_294 k038-0071 157 µM -0.408463061986105 0.308438872751735 no 2312 0.341466871880163 723 24152826 SGTC_2622 2-methoxyxanthone 59.94 µM -0.409195306585254 0.308131047885233 no 2313 0.341198169222278 716 71034 A hepatoprotective. SGTC_514 4466-0038 2.65 nM -0.410407399873864 0.307621798238442 no 2314 0.340753559452423 730 5722064 SGTC_1285 0929-0069 65.5 µM -0.41200935427743 0.306949320545868 no 2315 0.340166283463245 711 1206237 SGTC_178 4092-0806 87.505 µM -0.412357634546176 0.306803203248769 no 2316 0.340038655260433 710 2169044 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.412875937971143 0.306585811363869 no 2317 0.339848755570579 750 61125 An anti-inflammatory. SGTC_2797 7859098 81.82 µM -0.413697203406282 0.306241487519652 no 2318 0.339547937726301 711 972681 SGTC_1964 st076914 61 µM -0.414094327756191 0.306075050456588 no 2319 0.339402513369839 739 24208661 SGTC_3191 9110352 49.47 µM -0.414380379142434 0.305955189497464 no 2320 0.339297778025483 733 17122424 SGTC_2135 5326629 150.42 µM -0.416224873174252 0.305182810856692 no 2321 0.338622730230864 704 5020077 SGTC_1850 st056238 17 µM -0.41656017477073 0.305042496909101 no 2322 0.338500072167586 737 5393177 SGTC_1992 st073643 23.3 µM -0.417362625963295 0.304706810849635 no 2323 0.338206593758242 738 3161292 SGTC_3235 9132602 49.47 µM -0.417364983885639 0.30470582471188 no 2324 0.338205731546103 732 4912240 SGTC_2704 st078022 71.1 µM -0.418202186053207 0.304355777110281 no 2325 0.337899648805237 747 54697681 SGTC_2140 5586273 200 µM -0.420521009596313 0.303387176012885 no 2326 0.337052442319421 730 854421 SGTC_2451 5856223 45.7 µM -0.420842524642628 0.303252984024986 no 2327 0.336935038524498 716 2179896 SGTC_1660 st012960 28.1 µM -0.421455849456789 0.302997071877105 no 2328 0.336711122115765 753 24207266 SGTC_3169 9102970 49.47 µM -0.421708709373961 0.302891593241693 no 2329 0.336618823300681 709 17027839 SGTC_999 SEC7.066 22.7 µM -0.423233115756143 0.302256047026926 no 2330 0.336062593840687 709 740511 YDR170C SEC7 SGTC_1817 st052116 64.4 µM -0.423269652892621 0.302240821532137 no 2331 0.33604926647115 723 4361398 SGTC_1697 st025554 27.742 µM -0.423675023051668 0.302071921669195 no 2332 0.335901416555867 711 1269519 SGTC_104 0074-0074 590.992 µM -0.424456351900905 0.301746496036776 no 2333 0.33561651556619 727 3943124 SGTC_1782 st039423 80.636 µM -0.42532826888332 0.301383526398378 no 2334 0.335298694379428 746 2068169 SGTC_1479 0549-0158 134 µM -0.425700284165924 0.301228720291733 no 2335 0.335163127485855 725 5440202 SGTC_258 haloperidol 50.781 µM -0.426487597365719 0.300901215118024 no 2336 0.334876291791458 724 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_341 1486-1430 230 µM -0.426982025225497 0.300695625999981 no 2337 0.334696209951478 745 2054753 YPL210C SRP72 SGTC_391 gliotoxin 8.33 µM -0.427555174703626 0.300457382848078 no 2338 0.334487503488921 740 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1102 cgs 12066b 26.1 µM -0.428177760555002 0.300198686956392 no 2339 0.334260853227856 706 6438352 A 5-HT1B full agonist. SGTC_1281 0884-0031 11.8 µM -0.428351533894786 0.300126498913812 no 2340 0.334197602415769 715 1548255 SGTC_256 clotrimazole 625 nM -0.428440540819584 0.300089527147596 no 2341 0.334165207092865 708 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_3332 9141069 11.198 µM -0.428639692169918 0.300006810965874 no 2342 0.334092727630804 718 17332883 SGTC_354 2783-3500 4.88 µM -0.42873060905192 0.299969052676872 no 2343 0.334059641251647 739 6740761 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.429430323279999 0.299678529440704 no 2344 0.333805045135058 756 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_832 4083-0019 164 µM -0.429561581267111 0.299624044971202 no 2345 0.3337572944777 741 1990758 SGTC_896 0964-0007 44.5 µM -0.429888802395499 0.299488236823515 no 2346 0.333638265643392 713 6756758 SGTC_1547 harmine 94.2 µM -0.430793293091902 0.299112986981785 no 2347 0.333309338344868 712 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_3167 9103034 49.47 µM -0.430847515597519 0.299090498246261 no 2348 0.333289623844755 721 5127859 SGTC_2308 7584454 197.62 µM -0.431720783052018 0.298728417133699 no 2349 0.33297218020066 746 893577 SGTC_858 0438-0351 2.77 µM -0.432157537764027 0.298547401193954 no 2350 0.332813459274462 720 2799119 SGTC_2958 9077254 16.72 µM -0.434709960182195 0.29749053176052 no 2351 0.331886483905891 734 16457351 SGTC_2166 5933061 31.504 µM -0.434867993723432 0.297425151758976 no 2352 0.331829123857753 714 2877375 SGTC_89 0302-0250 142.109 µM -0.434978070925515 0.29737961563571 no 2353 0.331789172430358 735 4203518 YLR208W SEC13 SGTC_828 2074-0507 139 µM -0.435489384470078 0.297168140064149 no 2354 0.331603621342332 725 X828 SGTC_2718 lomofungin 53.02 µM -0.436553645289069 0.296728190129383 no 2355 0.331217543189153 744 5351222 A RNA synthesis inhibitor. SGTC_778 3456-2434 196 µM -0.440173895818123 0.295233868716005 no 2356 0.329905582328393 732 5539063 SGTC_131 0141-0277 33.849 µM -0.440485367624848 0.295105465303347 no 2357 0.329792803887126 758 1547771 SGTC_1166 k206-0078 225 µM -0.441390199509402 0.294732596753472 no 2358 0.329465268029392 715 5404595 SGTC_200 k038-0079 37.545 µM -0.44197608375015 0.294491277999836 no 2359 0.329253256282043 729 3436683 SGTC_1796 st049173 110.4 µM -0.442120646677611 0.294431748277943 no 2360 0.329200952275012 772 94134 SGTC_1350 1495-0454 146 µM -0.443220267978052 0.293979115993454 no 2361 0.32880321010291 733 1069057 SGTC_3076 9116187 49.47 µM -0.443689814753767 0.293785936588316 no 2362 0.328633430151515 744 27241210 SGTC_2408 sulbentine 18.36 µM -0.443704277295429 0.293779987389029 no 2363 0.328628201309164 747 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_251 melphalan 456.522 µM -0.44861751138849 0.291762151641676 no 2364 0.326853799620845 739 460612 A DNA alkylator. SGTC_2733 amorolfine 100 µM -0.449825690116069 0.291266950969835 no 2365 0.326418066165348 747 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_232 clozapine 119 µM -0.450240889939982 0.291096862111087 no 2366 0.326268377677386 734 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2239 6685329 187.64 µM -0.450659271889524 0.290925516616865 no 2367 0.326117570267208 734 805680 SGTC_1545 lovastatin 49.4 µM -0.453128421306212 0.289915254393693 no 2368 0.325228135431513 728 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_3346 9158254 43.5805 µM -0.453237269324293 0.289870756685175 no 2369 0.325188949150927 755 17639500 SGTC_788 1182-0090 188 µM -0.45348440846279 0.289769736650581 no 2370 0.325099983982118 720 5715185 SGTC_2677 mitomycin C 100 µM -0.454209379863348 0.28947349432267 no 2371 0.324839066250188 745 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2705 st078069 42.8 µM -0.454293668460958 0.289439061023668 no 2372 0.324808736295153 754 1530061 SGTC_668 1682-0499 62.6 µM -0.454330933101009 0.289423838409572 no 2373 0.324795327557977 745 682214 SGTC_46 0329-0187a 2.197 µM -0.454377492287837 0.289404819499481 no 2374 0.324778574732493 761 46494817 SGTC_1044 1222-0021 1.78 µM -0.454774744620275 0.289242570220155 no 2375 0.324635650676144 762 4306703 SGTC_1957 st077035 62.4 µM -0.454927092527108 0.289180358297712 no 2376 0.324580845559824 757 705593 SGTC_1305 1181-0477 144 µM -0.455450045916314 0.28896685590897 no 2377 0.324392748993973 732 6252086 SGTC_2321 7390090 138.78 µM -0.456302424539216 0.288619020512185 no 2378 0.324086260353355 752 649046 SGTC_2457 5731572 11.68 µM -0.456833269086423 0.288402495218187 no 2379 0.323895445504204 759 2865357 SGTC_2889 9059656 51.95 µM -0.458115509272971 0.287879800526599 no 2380 0.323434728501646 741 3949838 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.458356449088532 0.28778163333941 no 2381 0.323348187480631 751 2346 DNA damaging agent; causes G2/M arrest. SGTC_3059 1327-0034 3 µM -0.458989878612371 0.287523627778498 no 2382 0.323120717184667 728 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_14 0354-0009 295 µM -0.459003454257451 0.287518099407333 no 2383 0.323115842770719 751 1713507 SGTC_13 0199-0087 65 µM -0.459446742458131 0.287337608040768 no 2384 0.322956694269028 743 4589825 SGTC_269 exalamide 29 µM -0.459675195187538 0.287244611059973 no 2385 0.322874688250727 723 3316 A derivative of salicylamide. SGTC_1221 2958-7315 257 µM -0.459939816768673 0.287136908518741 no 2386 0.322779709726723 743 4562705 SGTC_486 niguldipine 82 µM -0.461251990290661 0.286603128826082 no 2387 0.322308912570306 727 1236 A calcium channel blocker. SGTC_707 0865-0008 204 µM -0.461620826740342 0.286453174452721 no 2388 0.322176628322111 756 723043 SGTC_2450 5739737 12.93 µM -0.462057849465199 0.286275546432004 no 2389 0.322019918023485 746 2262825 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.462160471607442 0.286233843214488 no 2390 0.321983123730577 715 6312947 SGTC_2923 7992654 58.14 µM -0.462384418956347 0.286142846314077 no 2391 0.321902835380294 715 2985126 SGTC_2121 5257820 149.641 µM -0.462750967380998 0.285993935741263 no 2392 0.321771440431101 747 791256 SGTC_721 1187-1332 279 µM -0.463069817164519 0.285864432738166 no 2393 0.321657161920812 750 25730 SGTC_1588 farnesol 29.9 µM -0.463804444436728 0.285566165059756 no 2394 0.3213939294082 726 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3077 9117319 49.47 µM -0.464382806966937 0.285331447043296 no 2395 0.321186752947743 764 17154678 SGTC_2570 licareol 100 µM -0.464811831179876 0.285157394681388 no 2396 0.321033107219843 750 443158 SGTC_145 3737-0113 38.366 µM -0.466384244919256 0.284519909522955 no 2397 0.320470243380238 736 6849351 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.466415718576002 0.284507156481223 no 2398 0.320458981226279 772 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2537 larixol 68.93 µM -0.468164694441543 0.28379890563807 no 2399 0.319833408886378 735 6708759 SGTC_3192 9110362 49.47 µM -0.468838631782517 0.283526219016134 no 2400 0.319592492076052 747 16649480 SGTC_3127 9126946 49.47 µM -0.469441527365296 0.28328238356169 no 2401 0.319377035525704 761 27243249 SGTC_1719 st032227 49.2 µM -0.469534709004565 0.283244706098295 no 2402 0.319343740679423 717 3125804 SGTC_1682 st012968 530 nM -0.470317747046198 0.282928184146587 no 2403 0.319064009967779 728 24207270 SGTC_1310 1188-0297 994 nM -0.470440171846144 0.28287871258878 no 2404 0.319020284520638 745 1588352 SGTC_2481 5478948 45.16 µM -0.470682297957514 0.2827808822627 no 2405 0.318933813767843 733 77792 SGTC_2675 theaflavin digallate 100 µM -0.4715035858561 0.282449164483659 no 2406 0.318640579780729 752 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2397 5161689 200 µM -0.473127835263968 0.281793682508786 no 2407 0.318060989523185 767 2259942 SGTC_558 k064-0027 21.3 µM -0.47348319493492 0.281650371394023 no 2408 0.317934243807374 732 5088526 SGTC_2682 pyrogallin 40.03 µM -0.473622353912715 0.28159426028617 no 2409 0.317884615948058 747 822798 An ATP competetive kinase inhibitor. SGTC_2110 5483698 200 µM -0.476688862605413 0.280359165648681 no 2410 0.316791847411077 737 2848765 YHR062C RPP1 SGTC_2164 5685496 200 µM -0.476814640232323 0.280308562376098 no 2411 0.316747059832728 749 759046 SGTC_3022 9087993 49.47 µM -0.47694051772591 0.280257923354043 no 2412 0.316702239382459 744 17173644 SGTC_1999 st074831 12.5 µM -0.477541119989706 0.280016369220969 no 2413 0.316488423564571 788 17112523 SGTC_1060 3448-7350 82 µM -0.478082616158244 0.279798673316801 no 2414 0.316295702215682 766 570178 SGTC_2992 9074591 71.4286 µM -0.478302952500625 0.279710115736946 no 2415 0.316217297623167 760 17741321 SGTC_300 r073-0011 5.04 µM -0.47883233650064 0.279497401339877 no 2416 0.316028955139134 762 2735780 SGTC_922 1866-0035 480 µM -0.478958378697779 0.279446767283028 no 2417 0.315984119298518 753 3156169 SGTC_85 0868-0259 160.055 µM -0.480328452759085 0.278896664537921 no 2418 0.315496930083173 750 83173 SGTC_1301 naphtanilide LB 4.81 µM -0.480497233674013 0.278828933250494 no 2419 0.315436934873008 760 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2281 7943571 200 µM -0.480532959049093 0.278814597788545 no 2420 0.315424236481777 764 1244024 SGTC_1215 3852-0577 11.2 µM -0.481269758030366 0.278519023694783 no 2421 0.315162393899185 732 2884876 SGTC_2218 6965428 192.983 µM -0.481637662934008 0.278371492215503 no 2422 0.315031683116655 745 675684 SGTC_2259 7964009 200 µM -0.483239738004752 0.277729497485156 no 2423 0.314462761412535 747 313134 SGTC_1182 1222-0449 220 µM -0.48332353679921 0.277695936956542 no 2424 0.314433015268316 746 658318 SGTC_1181 1222-0449 220 µM -0.484438516217689 0.27724958813111 no 2425 0.314037344596598 765 658318 SGTC_2903 5923464 63.88 µM -0.485941908818163 0.276648305777012 no 2426 0.313504176799735 764 2876576 SGTC_1458 k015-0034 6.33 µM -0.486093682835961 0.276587639243176 no 2427 0.313450372816261 765 3598957 SGTC_1567 st069303 68.4 µM -0.487053249117663 0.276204236067264 no 2428 0.313110297891221 767 5581319 SGTC_1035 k081-0041 55.2 µM -0.487094538561711 0.276187744360431 no 2429 0.313095668276894 771 731709 SGTC_3288 9119690 36.221 µM -0.487316171641011 0.276099228596076 no 2430 0.313017144603221 780 17595618 YKL019W RAM2 SGTC_802 4112-3352 742 µM -0.48782467644291 0.275896194722553 no 2431 0.312837015531671 730 704594 SGTC_3163 9099914 49.47 µM -0.487875644772037 0.275875848325859 no 2432 0.312818963341448 757 16268368 SGTC_43 0570-0105 72.5 µM -0.489364732654207 0.275281734717884 no 2433 0.31229174983402 771 1114046 YDL195W SEC31 SGTC_2044 5102272 200 µM -0.491278816692174 0.274518983109769 no 2434 0.311614630106409 746 592666 SGTC_2688 kanamycin b 96.69 µM -0.492890319701967 0.27387761789214 no 2435 0.311045043786604 764 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1013 4112-3890 241 µM -0.493503021892947 0.273633961882518 no 2436 0.310828602574578 750 705171 SGTC_700 3453-2283 142 µM -0.494588432739988 0.273202585181797 no 2437 0.310445334493657 744 565664 SGTC_3 0833-0587 95.581 µM -0.495545969944887 0.272822309460772 no 2438 0.310107390477996 750 5382644 SGTC_709 3807-1509 243 µM -0.497214834794003 0.272160165740735 no 2439 0.30951878062779 789 1886677 YPL242C IQG1 SGTC_2477 5967686 25.23 µM -0.499539588237162 0.271239123142282 no 2440 0.308699652397034 752 776118 SGTC_3223 9129970 49.47 µM -0.500023897239543 0.271047440817203 no 2441 0.308529125386803 742 17248386 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.50024763080006 0.270958913212108 no 2442 0.308450361905366 747 15053 SGTC_940 3232-1287 54.8 µM -0.500522910852176 0.270850009325989 no 2443 0.30835346401905 782 1585493 YIL048W NEO1 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.500604907192587 0.270817574874301 no 2444 0.3083246040936 775 7104 SGTC_1111 tnp00062 510.699 nM -0.501111134220859 0.270617374781292 no 2445 0.30814645562044 741 676306 SGTC_779 1360-0071 233 µM -0.504270467111671 0.269369610482357 no 2446 0.307035663891625 772 7566 SGTC_1017 4239-0030 168 µM -0.504899635741008 0.269121468033202 no 2447 0.306814664990468 741 1149593 SGTC_3172 9105863 49.47 µM -0.505146887289964 0.269023984077376 no 2448 0.306727835748603 754 2348785 SGTC_3256 9138902 49.47 µM -0.505951383953836 0.268706917595495 no 2449 0.306445389488703 784 17228773 SGTC_2684 capsaicin 100 µM -0.507293227029142 0.268178491366877 no 2450 0.305974545074786 778 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2727 riluzole 51.77 µM -0.509456494010409 0.267327685780814 no 2451 0.305216143011026 765 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.511480220419014 0.26653299579524 no 2452 0.304507417560728 762 94937 An inhibitor of serotonin biosynthesis. SGTC_1632 st005650 90 µM -0.512226420002607 0.266240275095929 no 2453 0.30424627730488 747 2759605 SGTC_2954 9074818 52.69 µM -0.513415269522248 0.265774247178617 no 2454 0.303830433324717 793 16648742 SGTC_1336 1486-0901 104 µM -0.513978674767436 0.265553537346023 no 2455 0.30363345014701 750 5006114 SGTC_1769 st044406 64.4 µM -0.514568737827716 0.265322484227167 no 2456 0.303427207753074 778 670903 SGTC_2805 7950783 58.44 µM -0.515595651388144 0.264920615462417 no 2457 0.303068424074495 748 1178958 YDL195W SEC31 SGTC_826 1683-5028 118 µM -0.51570118787976 0.264879332716618 no 2458 0.303031562428546 773 722377 SGTC_1734 st037168 69.4 µM -0.516877243131067 0.264419516125281 no 2459 0.302620927216987 765 708907 SGTC_2824 7998404 51.95 µM -0.516944644879794 0.264393175560393 no 2460 0.302597400563539 790 837851 SGTC_2806 7952793 58.44 µM -0.517135296909212 0.264318676089082 no 2461 0.302530857704898 766 2972490 SGTC_1455 4262-0120 131 µM -0.517354013610576 0.264233223190077 no 2462 0.302454527575584 757 1529587 SGTC_307 1501-1223 22.3 µM -0.518619335498053 0.26373913657312 no 2463 0.302013111397116 773 2830329 SGTC_3312 9133330 71.43 µM -0.520093177059795 0.263164221239759 no 2464 0.301499316825957 786 17617324 SGTC_1732 st034308 51.822 µM -0.521170615992078 0.262744339920061 no 2465 0.301123960870354 735 830119 SGTC_460 trequinsin 123 µM -0.52274691327743 0.262130669948755 no 2466 0.300575193399764 773 5537 A vasodilator. SGTC_2471 5466956 24.79 µM -0.522945792167848 0.26205329641104 no 2467 0.30050598838277 773 724419 SGTC_819 1013-0258 27.7 µM -0.523378295461383 0.261885072065618 no 2468 0.300355512602839 778 5753198 SGTC_1391 3442-0225 151 µM -0.523610169490744 0.261794906298012 no 2469 0.30027485342417 746 5227075 SGTC_2862 9027634 71.43 µM -0.524029386165138 0.261631931520179 no 2470 0.300129050512369 756 5012562 SGTC_457 grayanotoxin iii 135 µM -0.524498774089399 0.261449513963792 no 2471 0.299965836123707 780 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2546 rhodinyl acetate 100 µM -0.524758986978901 0.26134841594693 no 2472 0.299875372860637 756 6708682 SGTC_1347 1493-0251 600 nM -0.528108009709623 0.260049046932145 no 2473 0.298712185925399 763 3986378 SGTC_1914 st062367 72.6 µM -0.529627798272971 0.25946049317013 no 2474 0.298185008444027 765 978205 SGTC_1098 clofazimine 15.1 µM -0.529710055541055 0.259428657834147 no 2475 0.298156487501811 790 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1401 3807-4679 7.6 µM -0.530400411354821 0.259161554800983 no 2476 0.297917170434529 778 3291456 SGTC_444 curcumin 90.4 µM -0.531014394810627 0.258924120215018 no 2477 0.297704402031484 763 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_3184 9108758 49.47 µM -0.531385654143484 0.258780604500433 no 2478 0.29757578032883 771 902885 SGTC_1968 st069590 43.6 µM -0.531717307214241 0.258652433987658 no 2479 0.297460901555184 773 6384066 SGTC_593 1203-0218 61.7 µM -0.533442443912715 0.257986268833383 no 2480 0.29686367156174 784 3666956 SGTC_678 1218-2179 85.9 µM -0.533467763752671 0.257976498155275 no 2481 0.296854910101638 787 6820081 YOR116C RPO31 SGTC_1836 st055642 81 µM -0.533885704350771 0.25781524671301 no 2482 0.296710306625955 786 8571 SGTC_3023 9089636 49.47 µM -0.534100941143747 0.257732223639838 no 2483 0.296635849325278 789 17249241 SGTC_2890 9046729 58.44 µM -0.536487547245332 0.256812571429735 no 2484 0.295810820002825 769 903329 SGTC_77 0828-0286 12.516 µM -0.536499351279443 0.256808027124464 no 2485 0.295806742069985 761 745345 SGTC_3145 9085516 49.47 µM -0.536948265991031 0.256635235454543 no 2486 0.295651674934514 768 25236195 SGTC_518 1021-0119 62.6 µM -0.537138197828289 0.256562147060527 no 2487 0.295586078653284 788 1097762 SGTC_1529 apigenin 74 µM -0.537890515391549 0.256272751430253 no 2488 0.29532631839175 808 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2084 5306078 60.6385 µM -0.538365353682353 0.256090181989186 no 2489 0.29516242028592 779 679340 SGTC_2529 gangaleoidin 93.61 µM -0.538414577721294 0.256071259837315 no 2490 0.295145432209861 790 4565183 SGTC_273 hydroxyurea 18.1 mM -0.538608836112889 0.255996592327858 no 2491 0.295078394638773 798 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_998 3996-0085 177 µM -0.538639293830395 0.255984886260628 no 2492 0.295067884473232 782 715391 SGTC_701 4424-0219 185 µM -0.538915511541883 0.255878737968263 no 2493 0.294972576803793 782 2911779 SGTC_2459 5811157 9.22 µM -0.539666570844312 0.255590227980434 no 2494 0.294713498939763 780 2870684 YBR192W RIM2 SGTC_2296 7971656 126.45 µM -0.539959110582516 0.25547789851464 no 2495 0.294612615778572 765 666570 SGTC_2136 5328288 199.296 µM -0.541776884689366 0.254780487780746 no 2496 0.293986108565647 764 262395 SGTC_2374 9071832 200 µM -0.542351255313638 0.254560331036476 no 2497 0.29378827628507 785 17381698 SGTC_1399 3562-5772 25 µM -0.542828204111935 0.254377591924413 no 2498 0.293624046135228 781 23847490 SGTC_1704 st028805 70.8 µM -0.542850902350911 0.254368896990186 no 2499 0.29361623139737 780 2876101 SGTC_872 0588-0139 234 µM -0.543106907378662 0.254270840835936 no 2500 0.293528098532558 744 2047100 SGTC_1477 0139-0234 16 µM -0.543135892544542 0.25425974006124 no 2501 0.293518120806475 776 620880 SGTC_664 1222-0054 14.9 µM -0.544004837189312 0.253927068591823 no 2502 0.293219072088298 764 6813991 SGTC_2673 kobusone 100 µM -0.544330982587346 0.253802264307 no 2503 0.29310686508661 786 6710676 An epoxy ketone and protein crosslinker. SGTC_1378 2093-0007 380 nM -0.545070102547279 0.253519548521834 no 2504 0.292852652125474 803 3618014 SGTC_1309 pyrazolanthrone 13.4 µM -0.546394328564838 0.253013441853985 no 2505 0.292397453883824 786 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2153 5569715 200 µM -0.547349116684127 0.252648860960889 no 2506 0.292069452918673 765 2054701 SGTC_1147 3809-1045 12.3 µM -0.547408810127289 0.252626076523087 no 2507 0.292048951957193 762 325925 SGTC_2581 avocatin a 64 µM -0.547747721291488 0.252496737770261 no 2508 0.291932569884888 809 6710728 A skin care supplement. SGTC_2567 aureobasidin a 60 nM -0.549462103810509 0.25184301258452 no 2509 0.291344182261768 775 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1140 3229-1848 2.98 µM -0.549573655357195 0.251800506935725 no 2510 0.291305916203252 788 2849525 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.551252977778129 0.251161075182854 no 2511 0.290730133898839 798 364106 SGTC_2996 9066192 71.4286 µM -0.551616769626331 0.251022668259014 no 2512 0.290605472268265 774 6472854 SGTC_1159 4092-0538 61.2 µM -0.551669915474217 0.251002451961967 no 2513 0.290587262716857 776 717301 SGTC_2156 5649887 115 µM -0.551967017849315 0.250889452234296 no 2514 0.290485475306015 767 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.551981582376195 0.25088391346389 no 2515 0.290480485921495 773 16486 A toxic proline analog. SGTC_227 fluconazole 33.516 µM -0.554604017381251 0.249887678803603 no 2516 0.28958277027769 792 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1311 1190-0148 100 µM -0.554752414900742 0.249831367033824 no 2517 0.289532009593585 793 1961333 SGTC_820 1582-0060 59.9 µM -0.554821599671058 0.249805116088678 no 2518 0.289508345759109 777 3848840 SGTC_1016 4226-1401 38 µM -0.555082287378876 0.249706215876011 no 2519 0.289419188764137 787 2901613 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.555151130165192 0.249680101636231 no 2520 0.289395646209193 777 5379071 SGTC_263 alizarin 107.927 µM -0.555191786533597 0.249664680074878 no 2521 0.289381743144731 795 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_609 0986-0026 86.3 µM -0.555923452606589 0.249387234818656 no 2522 0.289131592443172 775 2848610 SGTC_151 3013-0144 2.285 µM -0.555925792500717 0.249386347801822 no 2523 0.289130792615466 784 906558 YHR107C CDC12 SGTC_1846 st056244 14.8 µM -0.55677497958758 0.249064545185939 no 2524 0.288840590365523 780 5393182 SGTC_3280 9140961 49.47 µM -0.557010864688728 0.248975194868533 no 2525 0.288760003036519 796 4901226 SGTC_1699 st031318 29.054 µM -0.557759336459673 0.248691796117563 no 2526 0.288504366702439 771 5340658 SGTC_2881 9058953 51.95 µM -0.557831656571929 0.248664422186137 no 2527 0.288479671825099 748 17122249 SGTC_3147 9097027 49.47 µM -0.557876769595981 0.248647347239669 no 2528 0.288464267754615 790 25236841 SGTC_433 pimozide 108 µM -0.559203676041597 0.248145402387841 no 2529 0.288011362316754 774 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_759 3486-0358 89.3 µM -0.559505872555553 0.248031162485464 no 2530 0.287908262244005 815 875103 SGTC_693 4161-2696 114 µM -0.560159162594803 0.247784293984721 no 2531 0.287685439535613 795 805759 SGTC_1314 1222-0010 41.1 µM -0.560831374474631 0.24753041220923 no 2532 0.287456248111152 791 3526027 SGTC_479 n-linoleoylglycine 10 µM -0.561223048291737 0.247382548486564 no 2533 0.287322746293831 801 6433346 An anti-infammatory. SGTC_2258 7960471 200 µM -0.561633654092655 0.24722758831148 no 2534 0.287182823024296 810 2974708 SGTC_3203 9113543 49.47 µM -0.563292891286333 0.246601931116888 no 2535 0.286617728975313 766 17018012 SGTC_538 2922-0838 53.3 µM -0.563417351587578 0.246555034442563 no 2536 0.286575362228999 773 777039 SGTC_3324 9138759 60.749 µM -0.564037544210947 0.246321416936529 no 2537 0.286364290663121 782 45595710 SGTC_2445 5742597 35.57 µM -0.564044122719612 0.246318939544528 no 2538 0.286362052179887 779 1774255 SGTC_204 PMA1.184 62.41 µM -0.564063836715868 0.246311515556367 no 2539 0.286355344105897 786 2252213 YGL008C PMA1 SGTC_3028 9087778 49.47 µM -0.564143461428925 0.246281531333225 no 2540 0.286328250994234 766 17217395 SGTC_659 k018-0002 107 µM -0.564226709969654 0.246250184580385 no 2541 0.28629992613999 784 6797879 YHR007C ERG11 SGTC_2468 5987765 72.9 µM -0.564284958703134 0.246228252631363 no 2542 0.286280108122607 753 26772094 SGTC_2317 5986382 200 µM -0.564403146975649 0.246183755325995 no 2543 0.286239898825341 807 877883 SGTC_2895 9054447 58.44 µM -0.565290146338903 0.24584994208061 no 2544 0.28593821490684 780 2697450 SGTC_768 0384-0033 77.3 µM -0.565820345332464 0.245650523122218 no 2545 0.285757957208154 786 3965305 YMR134W ERG29 SGTC_139 0099-0334 718.624 µM -0.565957682957946 0.245598881730562 no 2546 0.285711273810455 783 97690 SGTC_658 3253-0951 102 µM -0.567261857691648 0.245108779545251 no 2547 0.285268143520741 779 1184878 SGTC_3110 9122132 49.47 µM -0.567296436387239 0.245095792210574 no 2548 0.28525639888728 762 918317 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.5690774741873 0.244427356984343 no 2549 0.284651782203718 769 6708784 An antioxidant flavonoid SGTC_323 4013-0906 34.3 µM -0.569456085439185 0.244285388392508 no 2550 0.284523332285418 766 2910086 SGTC_2988 9073640 71.4286 µM -0.570149897746731 0.244025343651632 no 2551 0.284288017247713 807 9102229 SGTC_904 1141-0088 396 µM -0.571161030558244 0.24364663294403 no 2552 0.283945245699331 808 1378119 SGTC_2556 citropten 84.59 µM -0.572574212737061 0.243117870433253 no 2553 0.283466512030725 758 2775 A potential DNA crosslinker. SGTC_2279 7948423 32.93 µM -0.573888516956887 0.242626661986754 no 2554 0.28302162205153 749 1247112 SGTC_1121 fusaric acid 630.51 nM -0.574269676820551 0.242484307773308 no 2555 0.282892662740687 757 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_3228 9131799 49.47 µM -0.574322027078373 0.242464759721653 no 2556 0.282874953076919 793 17015818 SGTC_566 0958-0068 16.5 µM -0.575148327881585 0.242156324760551 no 2557 0.282595492827713 798 6815365 SGTC_1880 MG-132 525 µM -0.575186394685659 0.242142120615377 no 2558 0.282582621588058 786 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2603 homopterocarpin 100 µM -0.575295182321733 0.242101530378809 no 2559 0.282545839603582 789 101795 A weak amylase inhibitor. SGTC_3140 9094243 49.47 µM -0.575929844518071 0.241864802319299 no 2560 0.282331301050719 804 19291112 SGTC_472 calcifediol 10 µM -0.576145444626578 0.24178441238618 no 2561 0.282258438330641 780 5283731 A vitamin D metabolite. SGTC_432 NS 1619 61.3 µM -0.576604926244309 0.241613135741337 no 2562 0.282103185303396 767 4552 A K+/calcium channel activator. SGTC_2202 7226349 200 µM -0.576954723311141 0.241482789352322 no 2563 0.281985020870031 764 844334 SGTC_2929 9013348 24.6 µM -0.579542343458108 0.24051974062152 no 2564 0.281111641982504 772 2995952 SGTC_2216 7189485 200 µM -0.580444928686413 0.240184313171545 no 2565 0.28080730722947 778 731273 SGTC_2656 pseudo-anisatin 100 µM -0.58074396823496 0.240073237455873 no 2566 0.280706511867582 818 6708809 A neurotoxin. SGTC_3099 9120367 49.47 µM -0.581900688195355 0.239643847380091 no 2567 0.280316788464856 805 24824940 SGTC_2964 9083345 53.42 µM -0.582910328849906 0.23926939800493 no 2568 0.279976833514627 781 17741579 SGTC_1326 1431-2094 10.8 µM -0.583989668442372 0.23886945288671 no 2569 0.27961363152348 813 616278 SGTC_1074 carmofur 3.8 µM -0.584646548365345 0.238626227651978 no 2570 0.279392700870427 807 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_79 0052-0007 94.094 µM -0.586220358910364 0.238044039066622 no 2571 0.278863721046515 795 2801472 SGTC_1917 st066507 28.5 µM -0.587667276542231 0.237509478718652 no 2572 0.278377822092535 771 3156428 SGTC_134 0269-0018 6.916 µM -0.587738501613508 0.237483181808317 no 2573 0.278353914191182 777 4378915 SGTC_631 k072-0230 41.5 µM -0.588478736537979 0.237209975333796 no 2574 0.278105501068061 794 5773147 SGTC_2490 carminic acid 95.39 µM -0.58926008958397 0.236921780353907 no 2575 0.277843406614497 779 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3156 9099931 49.47 µM -0.591044917600159 0.236264185347848 no 2576 0.277245162594065 799 18111053 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.592399779547695 0.235765677178634 no 2577 0.27679145696547 809 688788 SGTC_3208 9114115 49.47 µM -0.595436662081293 0.234650395915637 no 2578 0.275775812554755 807 650895 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.596391475943973 0.234300348666382 no 2579 0.275456866791633 803 23847180 SGTC_36 0335-0881 14.2 µM -0.598705151047314 0.233453325095868 no 2580 0.274684760809601 789 23828853 SGTC_1029 k015-0030 64.7 µM -0.599388636396928 0.233203430309433 no 2581 0.274456876500158 790 2208316 SGTC_1879 gemcitabine 100 µM -0.600033216262498 0.232967896186795 no 2582 0.27424204938449 799 60750 A nucleoside analog which inhibits DNA replication. SGTC_1821 st053465 65.6 µM -0.600107038265336 0.232940929530614 no 2583 0.274217451112002 788 675086 SGTC_475 α-linolenic acid 10 µM -0.600818259042899 0.23268121444067 no 2584 0.27398052065785 793 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2364 9055074 200 µM -0.600912258688771 0.232646900820873 no 2585 0.273949213932188 812 6470630 SGTC_1557 sumaresinolic acid 42.3 µM -0.601442348747893 0.232453449473813 no 2586 0.273772699737015 782 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1749 st037932 54.2 µM -0.602357995356704 0.232119503741366 no 2587 0.273467931981888 816 594497 SGTC_757 1066-0008 322 µM -0.603369372622419 0.231750954637143 no 2588 0.273131496149616 773 6842497 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.604256214661233 0.231428055026174 no 2589 0.272836655988499 809 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1852 st056254 31.4 µM -0.604544643976257 0.231323091862494 no 2590 0.272740798597894 799 442583 SGTC_3036 9090181 49.47 µM -0.606324510090114 0.230675963348746 no 2591 0.272149642981433 809 25236586 SGTC_63 0099-0242 26.702 µM -0.606796312565221 0.230504593873922 no 2592 0.2719930477852 808 3898502 YLR359W ADE13 SGTC_3273 9137859 49.47 µM -0.607877759169612 0.230112056285265 no 2593 0.271634275755923 840 2377234 SGTC_2079 5212404 121 µM -0.607985867592319 0.23007283625275 no 2594 0.271598423533438 786 758462 SGTC_1919 st067113 52.3 µM -0.608174417626529 0.230004442222177 no 2595 0.271535899929961 806 1268243 SGTC_2214 7179297 48.276 µM -0.608302096394206 0.229958134900243 no 2596 0.271493565442523 781 769744 SGTC_770 0389-1121 67.2 µM -0.608718049852052 0.229807310534981 no 2597 0.271355670434863 793 6753108 SGTC_2199 6590217 200 µM -0.609388040489568 0.229564489007817 no 2598 0.271133631580204 773 703109 SGTC_1212 0520-0165 585 µM -0.609677000405581 0.229459807021217 no 2599 0.271037896528544 841 5403258 SGTC_2942 9052777 62.25 µM -0.610295968627543 0.229235662429813 no 2600 0.27083288347872 826 6469503 SGTC_2695 st077686 51.995 µM -0.610713458096298 0.229084547926126 no 2601 0.270694647422084 783 2876092 SGTC_2272 7805186 180 µM -0.610812252343438 0.229048796534652 no 2602 0.270661940550055 827 2956062 YPR165W RHO1 SGTC_1308 1187-1617 41.4 µM -0.610834451547361 0.229040763578261 no 2603 0.270654591542247 803 2882570 SGTC_1743 st037606 46.3785 µM -0.610883089375661 0.229023164150371 no 2604 0.270638490422224 768 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1348 1493-0373 93.8 µM -0.612877727290442 0.228302065291596 no 2605 0.269978595665671 823 3010129 SGTC_543 3844-1095 191 µM -0.613175325738721 0.228194587402448 no 2606 0.26988020894994 811 4230703 SGTC_1995 st072814 61.1 µM -0.613211377055105 0.22818156937616 no 2607 0.269868291522706 779 5769371 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.613649338227617 0.228023456211383 no 2608 0.269723536427021 788 688664 SGTC_2056 5235370 200 µM -0.613682306137635 0.228011556599178 no 2609 0.26971264143473 791 5511916 SGTC_1469 k284-2957 126 µM -0.614968457539071 0.227547598995235 no 2610 0.26928777569399 794 23884841 SGTC_2655 perillic acid 100 µM -0.616030617562021 0.227164843678033 no 2611 0.268937156236573 807 5702197 An apoptosis inducer. SGTC_2564 betulinic acid 100 µM -0.616634061764991 0.226947550935098 no 2612 0.268738061203977 820 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_3070 9117005 49.47 µM -0.617084505236487 0.226785428287622 no 2613 0.268589494155174 803 8779016 SGTC_1931 st074438 57.1 µM -0.617205118041426 0.226742028679078 no 2614 0.26854972016988 837 2787313 SGTC_2587 piperic acid 92.2 µM -0.61738447064105 0.226677501638802 no 2615 0.268490581280604 797 5370536 SGTC_809 3998-0021 90 µM -0.617612325009502 0.226595539698886 no 2616 0.268415459088201 815 715485 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.617641904298688 0.226584900901919 no 2617 0.268405707752534 829 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1275 0867-0008 21.1 µM -0.620148324382707 0.225684440413297 no 2618 0.267580069706362 800 3422836 SGTC_1899 st063254 59.6 µM -0.620646026217155 0.225505876486061 no 2619 0.267416274598475 804 3093813 SGTC_3120 9124077 49.47 µM -0.621813337934943 0.225087385872698 no 2620 0.267032307456957 815 18774327 YGL155W CDC43 SGTC_1625 st003711 30.1 µM -0.621820604505586 0.22508478212775 no 2621 0.267029918115563 800 24207034 YER133W GLC7 SGTC_3033 9090887 49.47 µM -0.622422177412478 0.22486928676628 no 2622 0.266832150697985 802 19325384 SGTC_654 1124-0271 80.9 µM -0.6226040791844 0.224804148976999 no 2623 0.266772364968497 807 5403748 SGTC_1607 st000305 50.6 µM -0.623316626156259 0.224549093805649 no 2624 0.266538237082192 822 5457690 SGTC_2269 7935389 174.42 µM -0.624653717653431 0.224070927196794 no 2625 0.266099177694515 795 97605 SGTC_620 0109-0052 432 µM -0.625119044286125 0.223904654265286 no 2626 0.265946464813817 823 493037 SGTC_1960 st011366 51.8 µM -0.625306872778969 0.223837558279854 no 2627 0.26588483503855 817 3972846 SGTC_2086 5274770 176.623 µM -0.625803127778516 0.22366034134883 no 2628 0.265722040022694 803 689278 SGTC_400 oxethazaine 37.5 µM -0.625833670251995 0.223649436975499 no 2629 0.265712022303739 807 4621 A local anesthetic. SGTC_2180 6301957 200 µM -0.626044231382234 0.223574269981592 no 2630 0.265642964927656 815 845462 SGTC_681 1642-0006 26.6 µM -0.626654398916549 0.223356530983677 no 2631 0.265442900732475 831 4446530 SGTC_76 0433-0009 400.328 µM -0.626714615315435 0.223335049235198 no 2632 0.265423160882125 834 2841569 SGTC_2720 fluspirilene 36.88 µM -0.627258257274167 0.223141162275934 no 2633 0.265244980516062 813 3396 An atypical antipsychotic. SGTC_1695 st026914 34.495 µM -0.627297031469009 0.223127337331673 no 2634 0.265232274472018 803 3289191 SGTC_2300 7976697 71.57 µM -0.627963906568004 0.222889639262877 no 2635 0.265013792342684 793 2236109 SGTC_2419 paclitaxel 166.5 µM -0.631508543216968 0.221628628185573 no 2636 0.263854032498996 812 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2844 9010103 25.97 µM -0.632486457887527 0.22128145211969 no 2637 0.263534527333915 836 2480525 SGTC_2652 actinonin 100 µM -0.633798469746941 0.220816154934681 no 2638 0.263106175995611 813 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1776 st049249 45.9 µM -0.636809241142445 0.219750523373093 no 2639 0.262124552970678 813 1822314 SGTC_2657 nystatin 74.44 µM -0.637591453943581 0.219474151127295 no 2640 0.261869830108811 801 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2939 9044578 71.43 µM -0.637815635808537 0.219394979786422 no 2641 0.261796850054182 815 2653634 SGTC_2821 7996764 71.43 µM -0.638497382785517 0.21915431709039 no 2642 0.261574978600289 767 2987135 SGTC_2790 5423970 71.43 µM -0.639419206111778 0.218829146808716 no 2643 0.261275128951025 816 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2731 amoxapine 43.43 µM -0.639561286679191 0.218779053037669 no 2644 0.261228928856156 847 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1356 1502-0781 85.8 µM -0.64071386701551 0.218372928303905 no 2645 0.260854301485365 809 567702 SGTC_171 k064-0041 9.68 µM -0.640795243889738 0.218344270662689 no 2646 0.260827861713178 801 53325 SGTC_34 0469-0683 81.75 µM -0.642709843438963 0.217670651563547 no 2647 0.260206196329025 796 3690923 SGTC_1662 st014054 52 µM -0.644666547677618 0.216983459235213 no 2648 0.259571649586437 812 2838777 SGTC_2242 6630449 61.2675 µM -0.644857162136354 0.216916582740111 no 2649 0.259509877265149 794 691249 YDR170C SEC7 SGTC_949 1165-0505 146 µM -0.644934411161148 0.216889483551027 no 2650 0.25948484537869 806 6244267 SGTC_205 1486-1330 71.903 µM -0.645203747133948 0.216795014994356 no 2651 0.259397579112438 813 4118834 SGTC_1145 3546-0597 10.2 µM -0.646041942798958 0.216501173365659 no 2652 0.259126096367053 818 875334 SGTC_2227 7312221 64.1025 µM -0.646181109571801 0.216452408754857 no 2653 0.259081035939082 830 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1717 st033143 58.0435 µM -0.646663292402466 0.216283499074908 no 2654 0.258924942626024 821 674616 SGTC_2434 5670830 169.91 µM -0.646942110209588 0.216185863428344 no 2655 0.258834705300933 835 1549830 SGTC_2811 7967822 32.47 µM -0.647075030543249 0.216139326739691 no 2656 0.25879169234483 804 2232244 SGTC_374 0880-0231 82.3 µM -0.648109632207792 0.215777301105216 no 2657 0.258457022237126 817 6833587 SGTC_3057 9095946 49.47 µM -0.651332027842876 0.214651981908478 no 2658 0.257416088944718 830 24540043 SGTC_1440 4100-1550 40 µM -0.653052081953816 0.214052706606632 no 2659 0.256861351357072 822 742806 SGTC_29 0299-0004 12.984 µM -0.653296002059613 0.213967802549466 no 2660 0.256782734665551 811 16871 A napthoquinone isolated from Swertia calycina. SGTC_2947 9072639 7.68 µM -0.653646143686134 0.213845959030335 no 2661 0.256669904135134 831 16488146 SGTC_985 1493-0307 8.71 µM -0.654650596233327 0.213496650363152 no 2662 0.256346370092487 825 3278274 SGTC_2257 7960413 200 µM -0.658502768605942 0.212160104690625 no 2663 0.255107559292866 813 2974689 YIL048W NEO1 SGTC_1726 st035556 14.5795 µM -0.658684101237376 0.21209731049847 no 2664 0.255049322234303 802 5919439 SGTC_1937 st074714 47.2 µM -0.659418360406386 0.211843152923302 no 2665 0.254813577579229 801 17250970 SGTC_2325 6158266 200 µM -0.659457943391424 0.211829456672955 no 2666 0.254800872123529 807 3623240 SGTC_1146 3579-1023 7 µM -0.660348940469877 0.211521296694607 no 2667 0.25451496519867 838 X1146 SGTC_737 1950-0117 57.9 µM -0.661804530468736 0.211018431847979 no 2668 0.254048251134938 818 5393513 SGTC_1355 1499-0035 1.68 µM -0.662428617503129 0.210803042399529 no 2669 0.253848284182368 826 1548538 SGTC_570 0987-0065 62.6 µM -0.662950741905808 0.21062294213874 no 2670 0.253681051101456 808 3104428 SGTC_950 1165-0508 94.1 µM -0.663682914810057 0.210370540411113 no 2671 0.253446638330234 828 6148369 SGTC_2319 6033012 152.6 µM -0.664261270452694 0.210171289653973 no 2672 0.253261552258918 826 847246 SGTC_2949 9072542 2.23 µM -0.665340250190094 0.209799864071208 no 2673 0.252916445919308 838 16457352 SGTC_2247 cerulenin 830 nM -0.666139725372148 0.209524903574132 no 2674 0.252660897454892 807 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2427 5545055 42.75 µM -0.667205383728309 0.209158725493325 no 2675 0.252320476363645 817 5372858 SGTC_1397 3532-0190 20.1 µM -0.667514662765007 0.209052522614984 no 2676 0.252221723474051 796 5322280 SGTC_1572 epiandrosterone 68.9 µM -0.66820989660634 0.208813903240284 no 2677 0.251999809523933 816 441302 A steroid. SGTC_1520 flindersine 88 µM -0.669196037932198 0.208475713500426 no 2678 0.251685216664832 824 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2352 9027995 87.8 µM -0.669408224320812 0.208402988024848 no 2679 0.251617553368964 814 2997347 SGTC_260 nsc-65238 3.989 µM -0.669480987410787 0.208378052404744 no 2680 0.251594352441673 824 3246252 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.670842954736475 0.207911636481334 no 2681 0.251160290005044 839 442882 SGTC_528 3492-0019 172 µM -0.671232936253862 0.20777819799821 no 2682 0.251036074891674 828 2869262 SGTC_758 0868-0029 16 µM -0.672787361379233 0.207246829168259 no 2683 0.250541289729032 805 762687 SGTC_1414 3917-0015 5.4 µM -0.673702378318906 0.206934413457519 no 2684 0.25025027476206 827 6618702 SGTC_789 1309-1135 70.6 µM -0.673763195026921 0.206913658593441 no 2685 0.250230938772821 815 3092424 SGTC_3248 9135562 49.47 µM -0.674351612507336 0.206712913512909 no 2686 0.250043898966204 825 17650701 SGTC_3112 9123419 49.47 µM -0.674445512751356 0.206680889087392 no 2687 0.25001405783329 847 17015854 SGTC_2243 6634756 200 µM -0.67447954846278 0.206669282025074 no 2688 0.250003241882998 786 885676 SGTC_2773 thioridazine 9.09 µM -0.675167849743882 0.206434636241358 no 2689 0.249784565136879 831 5452 An antipsychotic. SGTC_2018 5133068 143 µM -0.675306076671784 0.206387532942617 no 2690 0.249740662001968 841 785362 SGTC_502 l-744,832 89.3 µM -0.676652395617986 0.205929083869957 no 2691 0.249313263472338 848 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_781 4335-2806 94.4 µM -0.6779580977525 0.205485043176245 no 2692 0.248899130778523 853 845254 SGTC_64 000l-0018 272.079 µM -0.679141503992446 0.205083084213314 no 2693 0.248524103516408 823 6811119 SGTC_1339 1486-1321 22.7 µM -0.679732134211669 0.204882644100773 no 2694 0.248337042585337 827 3469382 SGTC_1056 3448-1962 115 µM -0.679955790289821 0.204806773136373 no 2695 0.248266227144648 824 715507 SGTC_3072 9116419 49.47 µM -0.68066260745033 0.204567109061623 no 2696 0.24804250090234 818 17170162 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.680724935759477 0.204545983095899 no 2697 0.248022777513459 815 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2053 5265679 138 µM -0.682387043842858 0.203983096350104 no 2698 0.24749712302705 848 764595 SGTC_2343 7990716 14.84 µM -0.68328273706703 0.203680145457749 no 2699 0.247214100165921 843 6456862 SGTC_1226 3909-7979 35.4 µM -0.683973535019949 0.203446679766777 no 2700 0.246995938772661 832 6615510 SGTC_3085 9117376 49.47 µM -0.684004925107477 0.203436074801893 no 2701 0.246986027894157 825 16480349 SGTC_2956 9076196 2.52 µM -0.684682766616205 0.203207150314243 no 2702 0.246772063053698 856 16423868 SGTC_1087 pterostilbene 9.05 µM -0.684728536240413 0.203191698280315 no 2703 0.246757619167906 846 5281727 Similar to reservatol, lowers cholesterol. SGTC_3148 9097893 49.47 µM -0.685598188511215 0.202898232994334 no 2704 0.246483262086013 800 17174100 SGTC_1936 st074407 74.3 µM -0.685685323733252 0.20286884306111 no 2705 0.246455781759584 835 809813 SGTC_1768 st044301 37.178 µM -0.685856541989654 0.202811100078758 no 2706 0.246401788475185 862 3931349 SGTC_3082 9117008 49.47 µM -0.687147604902419 0.202376008191987 no 2707 0.245994858954287 836 41448529 SGTC_419 nsc-638432 893 µM -0.68757596695721 0.202231772373808 no 2708 0.245859923424022 818 368090 SGTC_3161 9100388 49.47 µM -0.687890044021039 0.202126057081429 no 2709 0.245761013309537 839 25236368 SGTC_1653 st012112 65 µM -0.689387690583685 0.201622418717364 no 2710 0.245289663803612 836 720429 SGTC_3247 9135149 49.47 µM -0.689852108513726 0.201466394056327 no 2711 0.245143597811949 838 8934436 YOR116C RPO31 SGTC_2586 curcumin 80 µM -0.689965240671215 0.201428397428019 no 2712 0.245108023238721 831 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2165 5727197 32.143 µM -0.690800789338395 0.201147902611213 no 2713 0.244845369733377 836 1361712 SGTC_96 0929-0093 37.281 µM -0.691188236210515 0.201017915702538 no 2714 0.244723627801676 838 6991579 SGTC_2681 menadione 3.18 µM -0.695363613129208 0.199620293115441 no 2715 0.243413728887069 843 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2759 disulfiram 3.38 µM -0.698237658569119 0.198661671372678 no 2716 0.242514289555868 824 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_447 ml7 120 µM -0.699664278315681 0.198186863150175 no 2717 0.242068494956359 842 4216 Selective myosin light chain kinase inhibitor. SGTC_113 0099-0221 2.5 µM -0.700679863575037 0.197849273417198 no 2718 0.241751412670852 833 89219 SGTC_1128 3448-9350 235 µM -0.701418286186702 0.197604033327985 no 2719 0.241521006696742 818 619386 SGTC_285 1486-1325 46 µM -0.701773002794279 0.197486292531339 no 2720 0.241410368828229 849 22310230 SGTC_1868 st057644 42.7 µM -0.704986911076462 0.196421436989887 no 2721 0.240409190837571 839 688665 SGTC_1231 0242-0792 125 µM -0.705346664380948 0.196302457848202 no 2722 0.240297263499217 842 3707635 SGTC_3029 9088683 49.47 µM -0.706774694983768 0.195830604584457 no 2723 0.239853251247635 810 25236615 SGTC_1467 k284-1082 293 µM -0.707790162139959 0.195495490636705 no 2724 0.239537788290062 847 3334705 SGTC_1253 0550-0034 176 µM -0.707951391849361 0.195442315335008 no 2725 0.239487721843102 834 5969915 SGTC_2234 tolnaftate 200 µM -0.711113756624088 0.194401110090018 no 2726 0.238506872967746 848 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_532 1548-0774 215 µM -0.712329281940208 0.194001799785572 no 2727 0.238130447789703 862 5932993 SGTC_3138 9097216 49.47 µM -0.713759350086492 0.19353265075034 no 2728 0.237687999895867 845 25237486 SGTC_1581 himbacine 57.9 µM -0.715921582705183 0.19282462287666 no 2729 0.237019885431992 861 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1075 aripiprazole 15.2 µM -0.71885244326314 0.191867436030905 no 2730 0.236115920475629 841 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1658 st012944 20 µM -0.718868769452276 0.191862112236742 no 2731 0.236110890316121 833 24207260 SGTC_2402 5553605 200 µM -0.720512917675413 0.19132643644834 no 2732 0.235604624586418 859 6758546 SGTC_1885 st057546 99.9 µM -0.722863836791899 0.190562083669947 no 2733 0.234881771541875 832 702008 SGTC_379 3970-0972 5.9 µM -0.724395980832785 0.190064949168857 no 2734 0.234411333311618 854 2898042 YBL034C STU1 SGTC_3267 9137951 49.47 µM -0.724532415199418 0.190020719016374 no 2735 0.234369467022486 878 16643986 SGTC_3258 9138477 49.47 µM -0.725611300462857 0.189671182052543 no 2736 0.234038545760504 854 4970355 SGTC_892 0929-0076 29 µM -0.726201611174745 0.189480100849552 no 2737 0.233857592205305 845 5751038 SGTC_172 1112-0046 2.638 µM -0.728298068607449 0.188802443924833 no 2738 0.233215572191 848 2802135 YIL048W NEO1 SGTC_1475 4092-1048 11.7 µM -0.728840094854775 0.188627483162788 no 2739 0.233049741151663 859 2881759 SGTC_1104 tacrolimus 29.8 µM -0.729372348675193 0.188455774147347 no 2740 0.232886963690088 839 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_3351 9150312 21.596 µM -0.729955118140885 0.188267879008049 no 2741 0.232708809651966 846 4904905 SGTC_3092 9117248 49.47 µM -0.73159034487812 0.187741270580506 no 2742 0.232209321552334 867 17141857 SGTC_906 1165-0455 526 µM -0.731596899384638 0.187739161599622 no 2743 0.232207320647123 853 3252859 SGTC_3322 9139058 2.11 µM -0.732640681167855 0.187403500650346 no 2744 0.231888806079915 839 4908926 YPR165W RHO1 SGTC_236 1509-0011 5.31 µM -0.733241289362816 0.187210524392274 no 2745 0.231705638217019 864 3107280 SGTC_803 4488-1585 147 µM -0.733717631101808 0.187057562530173 no 2746 0.231560425317395 834 747204 SGTC_2972 9093619 59.92 µM -0.736265505647667 0.186240707737309 no 2747 0.230784567080718 834 25236256 SGTC_1234 0326-0494 15.5 µM -0.736284077717079 0.186234761613074 no 2748 0.230778916999105 849 1547813 SGTC_497 capsazepine 133 µM -0.737127955162547 0.185964705823773 no 2749 0.230522270190745 847 2733484 A calcium channel blocker. SGTC_1516 st013856 110 µM -0.737271144712449 0.185918906728562 no 2750 0.230478738066475 850 5281404 A mutagen and neurotoxin. SGTC_1628 st004252 77.7 µM -0.737739424916935 0.18576917641996 no 2751 0.230336404795798 845 692968 SGTC_881 0833-0569 170 µM -0.737840112149652 0.18573699194213 no 2752 0.230305807439747 851 5418700 SGTC_656 4090-1979 187 µM -0.739308175981742 0.185268121159354 no 2753 0.229859942877675 839 22330961 SGTC_2376 9072922 81.32 µM -0.740139978135845 0.185002786359693 no 2754 0.22960753149797 854 17087968 SGTC_3221 9128209 49.47 µM -0.741030491498125 0.184718985226182 no 2755 0.229337476316253 866 16460723 SGTC_1665 st014639 11.4 µM -0.741431712079184 0.184591207185345 no 2756 0.229215861227841 846 981133 YIL048W NEO1 SGTC_812 4251-0442 148 µM -0.7422289564967 0.184337469298133 no 2757 0.22897431360827 862 5723007 SGTC_1036 k216-0215 33.5 µM -0.743636461373275 0.183890034716738 no 2758 0.228548219280042 816 622330 SGTC_743 1275-0778 158 µM -0.743786293168877 0.183842444248288 no 2759 0.228502886904809 855 2849257 YMR203W TOM40 SGTC_1320 1313-0481 95.3 µM -0.743794653379308 0.183839789054371 no 2760 0.228500357629227 847 6813365 YLR208W SEC13 SGTC_74 000s-0487 160.283 µM -0.74421020041287 0.18370784186031 no 2761 0.228374658968206 825 677548 SGTC_547 1120-0019 610 nM -0.745075121986512 0.183433395610062 no 2762 0.228113153827202 831 3676939 SGTC_3294 9122953 26.2835 µM -0.745678848338946 0.18324198015708 no 2763 0.227930719716346 858 16459826 SGTC_1873 rapamycin 2 nM -0.74673468650586 0.182907519204697 no 2764 0.227611863784064 838 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1052 3253-3998 198 µM -0.746923242233578 0.182847829972862 no 2765 0.227554947680511 841 5450317 SGTC_2698 st077697 67.5 µM -0.747378288696984 0.182703830472746 no 2766 0.227417623575634 856 3154499 SGTC_3035 9091303 49.47 µM -0.747396848410154 0.182697958752828 no 2767 0.227412023608935 858 25237002 SGTC_2597 laccaic acid a 100 µM -0.747846183036117 0.182555839114619 no 2768 0.227276470924839 867 5491415 A textile dye. SGTC_2271 7849410 118.62 µM -0.747863884792358 0.182550241656317 no 2769 0.227271131693235 871 972430 SGTC_206 4546-0025 72.014 µM -0.748143008316368 0.182461994399336 no 2770 0.227186951361041 854 6620745 YIL048W NEO1 SGTC_1637 st007924 17.4 µM -0.748325648881918 0.182404265469548 no 2771 0.227131878653931 839 683336 SGTC_3355 9151058 44.0485 µM -0.749586895968177 0.182005922724738 no 2772 0.226751772734147 850 17015728 SGTC_2386 9075165 157.42 µM -0.750749912278585 0.181639086878715 no 2773 0.226401589234526 844 16452277 SGTC_3122 9126309 49.47 µM -0.751162894118568 0.181508936518018 no 2774 0.226277314175747 878 17591206 SGTC_2060 5238662 140 µM -0.753723091581628 0.180703398812494 no 2775 0.225507756588217 860 790130 SGTC_1240 0356-0016 42.1 µM -0.754192013147566 0.180556101084942 no 2776 0.22536696636765 819 4305613 SGTC_2897 9048598 12.99 µM -0.754612080686192 0.180424213357632 no 2777 0.225240886478862 859 6467404 SGTC_211 3455-0679 143.504 µM -0.756404598848593 0.179862099644499 no 2778 0.224703325776384 831 748649 SGTC_1900 st060200 72.8 µM -0.758617855920047 0.179169566256361 no 2779 0.224040594066457 860 688945 SGTC_1718 roemerine 11.9335 µM -0.758871813119405 0.179090209854282 no 2780 0.223964620888981 828 235224 An aporphine alkaloid with mutagenic activity. SGTC_1409 3909-8004 61.9 µM -0.764739872795257 0.177262723574756 no 2781 0.222213229023606 849 2119279 SGTC_1788 fluconazole 20 µM -0.764894115701646 0.177214847187136 no 2782 0.22216729906381 856 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2728 chlorpromazine 9.18 µM -0.765174652479247 0.177127790618932 no 2783 0.222083775608709 895 2726 A thorazine and dopamine antagonist. SGTC_3274 9138298 49.47 µM -0.765522290776289 0.177019948500227 no 2784 0.221980299072249 867 17015756 SGTC_3158 9100007 49.47 µM -0.76600397377739 0.176870592473974 no 2785 0.221836968866555 871 19297233 SGTC_493 zm226600 134 µM -0.766437839999666 0.176736131252883 no 2786 0.221707912344036 858 5240098 A potassium channel opener. YCR052W RSC6 SGTC_680 0417-1641 114 µM -0.770134590156585 0.175593078959826 no 2787 0.220610029676659 854 2835990 SGTC_3179 9107801 49.47 µM -0.770267698048217 0.175552008952025 no 2788 0.220570556689051 832 4818259 SGTC_1826 st055655 41.6 µM -0.7711156550942 0.175290517498435 no 2789 0.220319191050696 861 676168 SGTC_1272 0839-0021 27 µM -0.772154382795551 0.174970533304926 no 2790 0.220011497898736 875 5027250 SGTC_3220 9131269 49.47 µM -0.775851894524961 0.173834510388167 no 2791 0.218918219489583 877 17722206 SGTC_1518 st038567 90.8 µM -0.781694211661817 0.17204910338841 no 2792 0.21719715212151 883 77966 SGTC_174 3553-0389 74.3 µM -0.782508134093748 0.171801301629805 no 2793 0.216958003452942 855 738071 SGTC_3159 9100096 49.47 µM -0.782794274789942 0.171714239194398 no 2794 0.216873965069 855 25236875 SGTC_2726 cimetidine 79.27 µM -0.7836051158728 0.171467682209814 no 2795 0.216635926513691 869 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1646 st011709 75.6 µM -0.78401513485731 0.171343091617518 no 2796 0.216515614826326 865 5757843 SGTC_2916 7875993 68.79 µM -0.784213310726415 0.171282893573609 no 2797 0.216457478031025 866 1299250 SGTC_3130 9127414 49.47 µM -0.784520930702151 0.171189477497502 no 2798 0.216367252652001 867 1494646 SGTC_1372 2752-0194 270 µM -0.784627141490856 0.171157231648772 no 2799 0.216336105931782 853 823334 SGTC_2473 5854593 8.94 µM -0.784798715095651 0.171105149699186 no 2800 0.216285796798671 871 2872951 SGTC_107 0358-0022 2.6945 µM -0.785037397856474 0.17103271331948 no 2801 0.216215821059561 884 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2081 5214970 32.255 µM -0.786715962832488 0.170523850000958 no 2802 0.21572407872455 874 2063512 SGTC_647 0140-0236 81 µM -0.78675718780297 0.170511364704517 no 2803 0.215712009866745 861 990837 SGTC_2223 6903751 107.57 µM -0.787212983493663 0.170373362521684 no 2804 0.215578599030238 862 5598863 SGTC_231 b-estradiol 524 µM -0.787410261219266 0.170313654535001 no 2805 0.215520870923039 870 450 A steroid. SGTC_2786 7743617 45.45 µM -0.788008409057132 0.170132701328931 no 2806 0.215345893595832 860 583674 SGTC_2561 acetosyringone 100 µM -0.78835466328965 0.170028007941276 no 2807 0.215244640864755 883 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1842 st055362 61.2 µM -0.788787733800011 0.16989712292977 no 2808 0.215118039947817 848 676032 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.789051920655436 0.169817310619765 no 2809 0.215040830575149 871 688751 SGTC_1994 st072947 40.9 µM -0.789137599972397 0.16979143158811 no 2810 0.215015794002785 874 5286565 YDL195W SEC31 SGTC_818 4072-2707 53.5 µM -0.789144292329057 0.169789410299988 no 2811 0.215013838483399 873 882871 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.79422505511248 0.168259324389663 no 2812 0.21353221244602 869 6708561 SGTC_1993 st073995 70.8 µM -0.795229559012638 0.167957868647001 no 2813 0.213239990158308 867 3098394 SGTC_827 3253-0474 693 µM -0.79844159131222 0.166996259272837 no 2814 0.2123071377724 870 5402065 SGTC_2734 clemastine 41.6 µM -0.800972108863686 0.166241185400069 no 2815 0.211573896376071 905 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1708 st033234 31.827 µM -0.801754572318033 0.166008155406428 no 2816 0.211347470626785 851 674664 SGTC_350 k064-0020 19.8 µM -0.802247598191496 0.165861432956139 no 2817 0.211204873943742 856 2790705 SGTC_1730 st033808 45.1 µM -0.802292765242809 0.165847995621916 no 2818 0.211191813205982 873 1045166 SGTC_1078 idebenone 36.1 µM -0.804863631603944 0.165084315130789 no 2819 0.21044918863028 883 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2800 7887935 81.82 µM -0.805031967872986 0.165034390075675 no 2820 0.210400616274084 892 2961002 SGTC_1047 2043-3044 82 µM -0.805052277543311 0.165028367308507 no 2821 0.210394756493262 902 669592 SGTC_733 4069-0007 56.1 µM -0.806534976995852 0.164589062009286 no 2822 0.209967224377737 883 5717425 YNL287W SEC21 SGTC_771 0250-0039 27.3 µM -0.808147072716499 0.164112278930382 no 2823 0.20950296102339 880 3005115 SGTC_2775 cyproheptadine 69.59 µM -0.808635628115561 0.163967963988282 no 2824 0.209362382524016 860 2913 A selective serotonin reuptake inhibitor. SGTC_303 1348-1668 34.2 µM -0.808897378235031 0.163890679204187 no 2825 0.209287088547108 874 5380509 SGTC_1024 4507-0395 26 µM -0.809680691067844 0.163659538174401 no 2826 0.209061859193043 869 4201836 SGTC_2776 terbinafine 19.92 µM -0.814097882743636 0.162360071099386 no 2827 0.207794439356318 856 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2111 5486399 200 µM -0.814322834884429 0.162294073990114 no 2828 0.207730015765448 860 689674 SGTC_233 rapamycin 362 pM -0.816728859811525 0.161589279948952 no 2829 0.207041697422263 887 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3323 9138564 53.9225 µM -0.817786231967401 0.161280177225408 no 2830 0.206739630522877 879 43912313 YNL103W MET4 SGTC_997 3996-0078 137 µM -0.817999576970797 0.161217856646231 no 2831 0.206678714413947 869 735687 SGTC_1614 st002383 48.6 µM -0.819559991259911 0.160762519052177 no 2832 0.20623349469941 853 1947235 SGTC_1090 efavirenz 20.7 µM -0.819807581419388 0.160690348128643 no 2833 0.206162904204138 869 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_3056 9094900 49.47 µM -0.820652442841819 0.160444235824195 no 2834 0.205922133405625 882 25236784 SGTC_355 1311-2252 105 µM -0.820742848983062 0.160417914663718 no 2835 0.205896379112079 896 5338538 SGTC_787 4152-0075 138 µM -0.822204803273451 0.159992667915064 no 2836 0.205480172754547 863 9566539 SGTC_3189 9110682 49.47 µM -0.822607056696139 0.159875791673159 no 2837 0.20536574221442 886 17122418 SGTC_1171 0368-0077 21.4 µM -0.825064110214585 0.159163098270701 no 2838 0.204667597082871 876 3239779 SGTC_1122 capsaicin 818.572 nM -0.826273089202997 0.158813186676328 no 2839 0.204324597716348 874 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3295 9122362 53.5725 µM -0.826783713707621 0.158665549548398 no 2840 0.204179831323471 903 4730473 SGTC_2064 5220758 200 µM -0.827643710353793 0.158417101745212 no 2841 0.203936153079259 880 788518 SGTC_1573 oleylamine 1.06 µM -0.828139167436833 0.158274083132535 no 2842 0.203795845068496 882 5356789 An amine of the fatty acid oleic acid. SGTC_2887 9044784 58.44 µM -0.828394079608582 0.158200533218455 no 2843 0.203723679161837 874 6465546 SGTC_1297 1068-0111 14.1 µM -0.831702848159214 0.157247888282691 no 2844 0.202788346308526 874 767057 SGTC_952 1185-0122 232 µM -0.832035797040606 0.157152236520187 no 2845 0.202694369583143 877 678600 SGTC_2836 9010338 19.48 µM -0.832516707408592 0.157014144960633 no 2846 0.202558675835434 890 2994051 SGTC_3050 9093513 49.47 µM -0.834908984174499 0.156328398336981 no 2847 0.201884477959259 878 25236664 SGTC_2674 ligustilide 100 µM -0.835044001282957 0.156289754553773 no 2848 0.201846467168203 879 5319022 A signalling regulator. SGTC_1431 4049-0260 9.09 µM -0.835115369018268 0.156269330652941 no 2849 0.201826377045082 885 3854841 SGTC_1484 3473-2379 286 µM -0.836124962557766 0.155980595204969 no 2850 0.201542303258609 910 671917 SGTC_1470 k295-0292 231 µM -0.837714003330973 0.155526855332125 no 2851 0.201095673419695 899 5045612 SGTC_1361 1608-0041 5.61 µM -0.837766318071999 0.155511932030926 no 2852 0.201080979476742 873 X1361 SGTC_969 1313-0238 134 µM -0.841068749218811 0.154571792677493 no 2853 0.200154710538964 891 5212874 SGTC_2912 7964298 10.93 µM -0.843044853158735 0.154011033567086 no 2854 0.19960167953259 876 2975850 SGTC_3098 9119039 49.47 µM -0.845754043599365 0.153244436757491 no 2855 0.198844983747423 878 17161528 SGTC_1329 1447-1697 50.6 µM -0.847006791846854 0.152890813490426 no 2856 0.19849566788689 891 2840515 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.848968715712981 0.152338093616066 no 2857 0.197949350204941 893 5355888 SGTC_755 1995-0008 37.3 µM -0.849097089696119 0.152301973950913 no 2858 0.197913634847423 872 689533 SGTC_1235 benzylparaben 21.5 µM -0.849263820924544 0.152255070470825 no 2859 0.197867253803068 892 7180 SGTC_1153 4055-0057 267 µM -0.850441282078644 0.151924109638761 no 2860 0.197539896381496 885 882706 SGTC_2653 dihydrofissinolide 100 µM -0.851128558672276 0.151731150961302 no 2861 0.197348971360069 897 6857746 SGTC_1245 0418-0076 17.2 µM -0.852861563551191 0.151245318694476 no 2862 0.196868039428623 895 6790114 SGTC_1490 4089-0339 670 nM -0.854335123364485 0.150833034377223 no 2863 0.196459665694434 872 742542 SGTC_1019 4262-0212 3.4 µM -0.854442254620502 0.150803089541617 no 2864 0.196429995997337 888 4677213 SGTC_3279 9140807 49.47 µM -0.857150360788842 0.150047446717245 no 2865 0.195680895939184 907 45595718 SGTC_2925 9010536 32.5 µM -0.857442819948041 0.149965993138296 no 2866 0.195600101529651 842 2994177 SGTC_3088 9117578 49.47 µM -0.858141079575056 0.149771638247113 no 2867 0.195407283105422 915 678341 SGTC_3134 9127454 49.47 µM -0.858840202734891 0.149577211406212 no 2868 0.195214341941554 904 24262820 SGTC_1289 0976-0073 69.1 µM -0.858935837275262 0.14955062844769 no 2869 0.195187958114601 896 3391136 SGTC_2210 7115885 190.385 µM -0.859581592420226 0.149371214292277 no 2870 0.19500986276263 896 2927039 SGTC_177 1327-0068 8.361 µM -0.861021826679772 0.148971582889731 no 2871 0.194613010932095 878 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_395 anisomycin 6.25 µM -0.8651500930993 0.147830046651804 no 2872 0.193478206687552 903 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_17 0960-0276 49.807 µM -0.865787824451269 0.147654226680171 no 2873 0.193303263667799 885 6821114 SGTC_2591 skatole 100 µM -0.866873906850172 0.147355120613282 no 2874 0.193005550874314 892 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2883 9059145 45.46 µM -0.866984979950067 0.147324554089327 no 2875 0.192975119726625 914 16476510 SGTC_2357 9067248 200 µM -0.867879065757234 0.147078662837898 no 2876 0.192730270148989 924 9150235 SGTC_1716 st033144 30.6155 µM -0.871474616063857 0.146092595192835 no 2877 0.191747529975036 888 674617 SGTC_1097 itavastatin 7.23 µM -0.873110877749027 0.145645329628668 no 2878 0.191301322702541 878 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2696 st077691 74.316 µM -0.873609117989316 0.145509320698455 no 2879 0.191165579485322 904 757133 SGTC_848 0368-0089 85.6 µM -0.873988443262854 0.145405830297833 no 2880 0.19106227369899 889 762535 SGTC_2993 9054257 71.4286 µM -0.874202209062304 0.145347530907069 no 2881 0.191004071614657 880 6470217 YGL055W OLE1 SGTC_3141 9094609 49.47 µM -0.874717023479444 0.145207192415814 no 2882 0.190863947560047 909 25236309 YDL196W YDL196W SGTC_871 0574-0004 149 µM -0.876881678711872 0.144618104995234 no 2883 0.190275454254383 909 9551173 SGTC_3115 9123671 49.47 µM -0.877081855575098 0.144563710472419 no 2884 0.190221089597756 914 3286988 SGTC_1442 4112-3290 3 µM -0.877247296118103 0.144518765335022 no 2885 0.190176165942754 905 704353 SGTC_2066 5222451 176 µM -0.877257313758422 0.14451604415076 no 2886 0.190173445966271 877 2281147 SGTC_1834 st055981 52.8 µM -0.877574430268173 0.144429920704925 no 2887 0.190087355265157 875 471719 YDL150W RPC53 SGTC_140 0062-0056 502.533 µM -0.877987631265915 0.144317754251555 no 2888 0.189975215516643 906 3758964 SGTC_3350 9150499 3.57 µM -0.878074333647867 0.14429422570619 no 2889 0.189951690282919 907 4910996 YPR165W RHO1 SGTC_1816 st051957 91.6 µM -0.878468396197909 0.144187320989528 no 2890 0.189844790603062 926 674121 SGTC_2940 9060638 45.86 µM -0.878489586541745 0.144181573802031 no 2891 0.189839043221353 878 4027022 SGTC_1952 st077036 64.1 µM -0.879800555948648 0.14382631656676 no 2892 0.189483681725272 896 2937007 SGTC_2001 4023502 57.655 µM -0.88096002092055 0.143512607764058 no 2893 0.189169729547366 902 108941 YCR052W RSC6 SGTC_2238 6671620 73.2395 µM -0.882894847041338 0.142990143802082 no 2894 0.188646544001112 877 729941 SGTC_3241 9133421 49.47 µM -0.883741151057747 0.1427620196124 no 2895 0.188417980341585 930 17018221 SGTC_886 0866-0150 153 µM -0.890498682223853 0.1409493305538 no 2896 0.186599087841423 910 271463 SGTC_960 1222-0186 7.7 µM -0.890810586666186 0.140866041671775 no 2897 0.186515397339507 908 3126296 SGTC_370 0180-0345 38.7 µM -0.891681909982896 0.140633546254527 no 2898 0.186281726225174 878 3989527 SGTC_1963 st076565 50.3 µM -0.891857034305446 0.140586849238807 no 2899 0.186234783360965 921 4914280 SGTC_404 fumagillin 50 µM -0.894508671615991 0.139881074507463 no 2900 0.185524896089842 891 12015870 A methionine aminopeptidase binder. SGTC_711 k292-0785 179 µM -0.896633861069029 0.13931716341875 no 2901 0.184957161683584 875 4146315 SGTC_850 0388-0143 75.9 µM -0.897793382816628 0.13901014171347 no 2902 0.18464785656555 898 67273 SGTC_927 2425-1185 123 µM -0.901571146379138 0.138013050662251 no 2903 0.183642362076646 909 730375 SGTC_2173 5763948 167 µM -0.903563532499444 0.137489155953184 no 2904 0.18311344281809 896 2867177 SGTC_2095 5432005 200 µM -0.903721723382137 0.137447618172241 no 2905 0.183071488603736 921 783734 SGTC_1385 3091-4834 14.1 µM -0.903961728645927 0.137384613923776 no 2906 0.183007847637317 894 4072814 SGTC_1076 itraconazole 331 nM -0.904749727905688 0.137177893386533 no 2907 0.182798994989087 898 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2601 securinine 100 µM -0.905278018946185 0.137039422686945 no 2908 0.182659059187961 907 442872 A GABA receptor antagonist. SGTC_1428 4049-0204 61.7 µM -0.905491721457862 0.136983436126103 no 2909 0.182602471835788 908 X1428 SGTC_1230 0170-0365 3.77 µM -0.906985356201682 0.13659256467572 no 2910 0.182207270573742 876 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2251 lansoprazole 556 µM -0.910206745697039 0.135752152941674 no 2911 0.181356743652112 919 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_3102 9121669 49.47 µM -0.910340687285969 0.13571728646403 no 2912 0.181321433654278 916 41905072 SGTC_1722 st034304 3.6505 µM -0.910675357838915 0.135630194827995 no 2913 0.181233225830828 925 4036148 YLR033W RSC58 SGTC_197 4544-0043 41.561 µM -0.91124118061445 0.135483037330704 no 2914 0.181084155249774 912 896523 SGTC_1771 st048882 4.1505 µM -0.9122257439589 0.135227235943382 no 2915 0.180824947271442 908 4580403 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.91389929693127 0.134793186934098 no 2916 0.180384881569632 884 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2813 7971799 71.43 µM -0.914259825914327 0.134699806216912 no 2917 0.180290167449404 922 2234054 SGTC_1822 st052468 42 µM -0.915629798356322 0.134345374163667 no 2918 0.179930548372074 904 2873678 SGTC_2294 7971431 200 µM -0.922144358968645 0.132668728222875 no 2919 0.178226640730932 939 5741572 SGTC_2016 5121758 140 µM -0.922891922255943 0.132477254548957 no 2920 0.17803176529382 900 2795203 SGTC_3002 9075603 71.4286 µM -0.923147360645812 0.132411872685219 no 2921 0.177965208203384 890 20105405 SGTC_2 0422-0095 29 µM -0.924687718976311 0.132018074836754 no 2922 0.177564184718004 886 6790840 SGTC_368 fentichlor 4.58 µM -0.925074636779177 0.13191928503475 no 2923 0.177463542569205 942 7329 A pesticide. SGTC_2409 alverine citrate 63.97 µM -0.92563771332567 0.131775608613957 no 2924 0.177317143679101 897 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1674 st016616 23.6 µM -0.926843016168798 0.131468422668843 no 2925 0.177004023527441 891 625830 SGTC_1884 5633444 25 µM -0.928768355324641 0.130978752999783 no 2926 0.176504573690699 904 5724239 SGTC_1127 asiatic acid 681.4 nM -0.930387479334003 0.130567939377721 no 2927 0.176085249457562 929 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_921 1561-0023 372 µM -0.93070197875239 0.130488246196919 no 2928 0.176003872923942 892 24050882 SGTC_2875 9039966 71.43 µM -0.931069117134583 0.130395257029178 no 2929 0.175908906219127 919 6463691 SGTC_897 1000-0139 31.4 µM -0.931606932544226 0.130259121386295 no 2930 0.175769849541397 915 6151020 SGTC_808 0711-0032 135 µM -0.931797935272287 0.130210797095227 no 2931 0.175720480947798 890 4252555 SGTC_1902 st060212 70.5 µM -0.931851670192643 0.13019720422742 no 2932 0.175706593633105 885 688944 SGTC_516 3992-2719 87.3 µM -0.931851994673556 0.130197122149213 no 2933 0.175706509775997 932 5350887 YDR037W KRS1 SGTC_2072 5231554 129 µM -0.933474165407893 0.129787237701738 no 2934 0.17528760160532 904 789545 SGTC_2274 7947094 46.08 µM -0.935249760686189 0.129339611770083 no 2935 0.174829799811956 903 2971028 SGTC_299 1273-0059 1.44 µM -0.935291362569858 0.12932913681707 no 2936 0.174819082703327 890 2848077 SGTC_2191 5911152 200 µM -0.936713974565461 0.128971290610008 no 2937 0.174452852959079 902 2875902 SGTC_1276 0871-0068 94.2 µM -0.936774020332162 0.128956201714989 no 2938 0.174437405819306 908 3414906 SGTC_2314 7727897 200 µM -0.939467137158454 0.128280707203905 no 2939 0.173745478587487 869 900724 SGTC_193 1273-0060 1.558 µM -0.939714612110534 0.128218758385451 no 2940 0.173681983957587 915 2847393 YHR072W ERG7 SGTC_325 2810-4341 181 µM -0.940163059963924 0.128106554248649 no 2941 0.173566963343654 886 774970 SGTC_2701 st077767 14.721 µM -0.9430224909976 0.127392712681712 no 2942 0.172834699496834 900 5721188 SGTC_471 1-acyl-paf 4 µM -0.944052273073625 0.127136311966713 no 2943 0.172571468345531 898 16759367 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.944320342322706 0.127069625578681 no 2944 0.17250298689497 916 97141 SGTC_295 k015-0027 31 µM -0.946031087181089 0.126644624588863 no 2945 0.172066365244247 918 3887424 SGTC_2460 5552655 174.22 µM -0.947307674342691 0.126328127241539 no 2946 0.171741010692039 913 5401989 SGTC_2236 dapsone 200 µM -0.948726925579458 0.125976907452886 no 2947 0.171379757971155 900 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_250 brefeldin a 552.239 µM -0.949300441055636 0.125835173856681 no 2948 0.171233914650166 913 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1985 st071382 65.5 µM -0.950461610257489 0.125548553300063 no 2949 0.170938875756978 949 6123237 SGTC_621 3584-0052 32.1 µM -0.953558802258988 0.124786278205245 no 2950 0.1701535089435 912 2273927 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.957885965695988 0.123726709746334 no 2951 0.16906013202919 906 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1131 3454-3128 32.3 µM -0.95817662406741 0.123655764294445 no 2952 0.16898685126991 896 710982 SGTC_1891 st059073 26.2 µM -0.960246335401425 0.123151401639926 no 2953 0.168465625886736 915 688754 SGTC_1853 st056710 91.2 µM -0.963006759809392 0.122480967274045 no 2954 0.167772065471584 923 269167 SGTC_2354 9060492 162 µM -0.963434448454326 0.122377322552397 no 2955 0.167664772841098 949 6471895 SGTC_2850 9015429 58.44 µM -0.966870630274842 0.121546842774934 no 2956 0.16680435518411 932 6457570 SGTC_1141 3253-0389 52.6 µM -0.967929559947615 0.121291713797778 no 2957 0.16653977511451 923 5402031 SGTC_2041 5107442 45.335 µM -0.968130914622337 0.121243243859088 no 2958 0.166489496084063 910 793005 SGTC_1116 jasmonic acid  1.58368 µM -0.971551107201577 0.120422018006877 no 2959 0.16563695808418 914 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_3290 9121031 71.43 µM -0.971986962009738 0.120317646588074 no 2960 0.165528517423507 914 17014854 SGTC_1645 Cervolide 78 µM -0.972065068973507 0.120298949538164 no 2961 0.165509089266674 923 23173 A fragrance. SGTC_1416 3966-0321 25.3 µM -0.97328667854952 0.120006790011448 no 2962 0.16520542069603 918 582530 YLR208W SEC13 SGTC_2772 vinpocetine 57.06 µM -0.974430282364683 0.119733739864523 no 2963 0.164921469865696 935 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_615 k087-0205 167 µM -0.974830706131499 0.119638237166328 no 2964 0.164822121494956 923 9642773 SGTC_15 0266-0086 27.098 µM -0.97728082786156 0.11905504326582 no 2965 0.164215070977221 939 1712902 YIL048W NEO1 SGTC_3301 9125354 19.7965 µM -0.977378412900272 0.119031857077043 no 2966 0.164190923037538 893 41905162 SGTC_82 0054-0107 293.755 µM -0.987979095548456 0.116532096034816 no 2967 0.161581443113139 918 3104697 SGTC_1672 st016598 6.51 µM -0.989904336333517 0.116082127029793 no 2968 0.161110439894942 929 4665860 YNL267W PIK1 SGTC_2792 7535235 81.82 µM -0.993484932024636 0.115248549626353 no 2969 0.160236844971453 926 1281891 SGTC_1981 st071826 47 µM -0.993985293408833 0.115132403153667 no 2970 0.160115013667266 901 11838600 SGTC_2108 5365811 200 µM -0.994271363611575 0.115066036463347 no 2971 0.160045386617018 914 780283 SGTC_2293 7624732 200 µM -0.997469348562782 0.114325973214952 no 2972 0.159268372306456 910 894453 SGTC_1493 4348-0038 111 µM -0.998246880153787 0.114146553672782 no 2973 0.159079829450568 931 800424 SGTC_1227 3909-8010 46.6 µM -0.998449500138951 0.114099830994661 no 2974 0.159030720360924 925 15982272 SGTC_1461 k072-0203 53.8 µM -0.99870936246043 0.114039928596341 no 2975 0.158967751962736 912 5418714 SGTC_2922 7999257 32.47 µM -0.999248597425091 0.113915697847993 no 2976 0.158837139665948 945 2988377 SGTC_800 3448-7362 155 µM -1.00013468546304 0.113711767408703 no 2977 0.158622666187078 933 15991913 SGTC_343 4130-2827 29.8 µM -1.00036206695933 0.113659478238651 no 2978 0.158567660187256 928 1118244 SGTC_1833 st055984 71 µM -1.00283686271645 0.113091476825804 no 2979 0.157969789868088 919 676288 SGTC_1419 3993-2473 62.6 µM -1.00323741435015 0.112999735219075 no 2980 0.157873162463005 934 704026 SGTC_877 0771-0151 33.1 µM -1.00444267379929 0.112724005225689 no 2981 0.15758264485609 940 6166523 SGTC_1005 4092-0690 4.4 µM -1.00735786037342 0.11205907840886 no 2982 0.156881416985741 945 1529343 SGTC_895 0964-0006 13.7 µM -1.00891944433983 0.111704051196747 no 2983 0.156506634565285 946 6738897 SGTC_2464 5717415 7.67 µM -1.00981756882981 0.111500226795347 no 2984 0.156291350634467 918 5285744 SGTC_1635 st007035 42.4 µM -1.01500082384381 0.110329115019536 no 2985 0.155052717396417 902 3716403 SGTC_3146 9095609 49.47 µM -1.01684795868396 0.109913910126469 no 2986 0.154612881687012 943 17173999 SGTC_2217 6934799 96.0675 µM -1.02045717864652 0.10910585667687 no 2987 0.153755843985095 930 675606 SGTC_1485 3909-9022 254 µM -1.02167113607887 0.108835030556123 no 2988 0.153468288345733 957 714516 SGTC_855 0428-0020 25 µM -1.02170694697399 0.108827048721046 no 2989 0.153459811067815 924 6812414 SGTC_1161 k007-0610 110 µM -1.02171401409978 0.108825473590026 no 2990 0.153458138150203 918 5843850 SGTC_1249 0481-0015 10.2 µM -1.02399787753449 0.108317301149471 no 2991 0.152918138705771 927 4227577 SGTC_387 norethindrone acetate 66.7 µM -1.029484961656 0.107103379487268 no 2992 0.151625921441473 956 541197 SGTC_1527 coumarin 137 µM -1.03156801119144 0.106645120051132 no 2993 0.151137266167249 963 323 A hepatotoxic, DNA x-linker. SGTC_1774 st048371 48.465 µM -1.03247531113394 0.106445962124774 no 2994 0.15092475379537 950 4242727 SGTC_2853 9015042 58.44 µM -1.03270512111268 0.106395560069292 no 2995 0.150870958125523 921 6457456 SGTC_1395 3486-0190 4.35 µM -1.03478559280738 0.105940053861547 no 2996 0.150384526342972 947 6748079 SGTC_3281 9140613 49.47 µM -1.03496237178844 0.105901414275788 no 2997 0.150343242151855 915 16013766 SGTC_375 3970-0961 9.27 µM -1.035183897281 0.105853008571005 no 2998 0.150291518718074 921 2898222 SGTC_448 monastrol 171 µM -1.03751903918323 0.105343727447288 no 2999 0.149747013655029 942 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2222 6885208 172.143 µM -1.03798061746297 0.105243270027976 no 3000 0.149639539459821 947 609514 SGTC_2144 5628481 200 µM -1.03839682743286 0.105152745967203 no 3001 0.149542672990625 910 2818399 SGTC_3321 9137793 26.8275 µM -1.03876479336563 0.105072761738626 no 3002 0.149457069438655 933 4904192 SGTC_2715 st079500 56.4 µM -1.03876553848707 0.10507259981733 no 3003 0.149456896126878 929 28246688 SGTC_2865 9030313 51.95 µM -1.03930230549853 0.104956002651864 no 3004 0.149332081474998 951 42562754 SGTC_1870 st057514 26.5 µM -1.0393213663426 0.104951863955546 no 3005 0.149327650529009 929 5393161 SGTC_3008 9078912 71.4286 µM -1.04023085845841 0.104754522495197 no 3006 0.14911632904035 953 16648731 SGTC_1986 st071812 45 µM -1.04250080248631 0.104263162975441 no 3007 0.148589776803813 949 11838594 SGTC_793 0488-0545 106 µM -1.04301984395464 0.104151044595085 no 3008 0.148469551116703 938 292548 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.04327011192112 0.104097015342186 no 3009 0.148411604745158 963 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_966 1300-0360 30.2 µM -1.04377880034031 0.10398725946583 no 3010 0.148293871019951 901 70588 SGTC_2334 9017922 200 µM -1.04586701672709 0.103537580025985 no 3011 0.14781121723007 938 3163164 SGTC_981 1488-1094 54.9 µM -1.04637380436869 0.103428660786324 no 3012 0.147694241137828 933 3449522 SGTC_1197 1601-0112 267 µM -1.04642836477847 0.103416939576566 no 3013 0.14768165126967 945 7350313 SGTC_2009 4012297 12.05 µM -1.04647403762376 0.10340712842321 no 3014 0.147671112768437 938 45595307 SGTC_10 0279-0212 42.575 µM -1.05105421469602 0.102426671970893 no 3015 0.146616845369204 953 39851 YBR002C RER2 SGTC_2753 fluvastatin 17.09 µM -1.05639408847351 0.101292146249904 no 3016 0.145394102828999 957 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_903 1134-0042 114 µM -1.05957255097098 0.100621202336597 no 3017 0.14466955336544 931 701009 SGTC_358 0075-0058 9.45 µM -1.05982524348489 0.100568000733554 no 3018 0.144612055146047 984 1069125 SGTC_1294 1000-1494 117 µM -1.0602883512911 0.100470551798548 no 3019 0.14450671852564 936 712797 YDL207W GLE1 SGTC_318 1488-0629 67.2 µM -1.06338180221413 0.0998213826096118 no 3020 0.143804420955835 961 3662576 SGTC_833 3852-0053 558 µM -1.0655184246842 0.0993747989076953 no 3021 0.143320696205984 974 3123681 SGTC_2389 9091542 195.52 µM -1.06585898517634 0.0993037522118762 no 3022 0.143243696005454 935 3626624 YOL127W RPL25 SGTC_572 0960-0087 17.7 µM -1.06655558623513 0.0991585450965246 no 3023 0.143086282622201 958 6796365 SGTC_3171 9103192 49.47 µM -1.06707340942675 0.099050705046778 no 3024 0.142969344054207 963 13018434 SGTC_1018 4259-0013 28.1 µM -1.06759187868483 0.0989428164206666 no 3025 0.142852324304951 951 6801262 SGTC_2658 polymyxin b sulfate 77.05 µM -1.06873976996538 0.0987042568626599 no 3026 0.142593472884869 949 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_488 nitrendipine 139 µM -1.07136289735797 0.0981606882871331 no 3027 0.142003144405754 974 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2337 9009472 200 µM -1.07173692268847 0.0980833611552618 no 3028 0.141919105875553 929 5742383 SGTC_3206 9114350 49.47 µM -1.07419448071414 0.0975763879617653 no 3029 0.141367762792996 923 17087243 SGTC_2628 lathosterol 100 µM -1.07604439534921 0.0971960360023113 no 3030 0.140953700942578 956 6710616 SGTC_100 0086-0128 49.5915 µM -1.08501211586118 0.0953676398407036 no 3031 0.138958144574191 951 93297 SGTC_2085 5307070 144.047 µM -1.0879955157457 0.094765013554629 no 3032 0.138298543583352 964 2840351 SGTC_2521 angolensin 13.4 µM -1.08880730893025 0.094601523629416 no 3033 0.138119433919842 946 821428 A flavenoid. SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.09038204892467 0.0942849741426138 no 3034 0.137772442983798 916 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_3275 9138069 49.47 µM -1.0953993368425 0.093281624430939 no 3035 0.136670862260219 961 17617007 SGTC_2043 5101342 149 µM -1.09629085669769 0.0931041681216363 no 3036 0.136475754710389 969 678451 SGTC_947 3447-0010 211 µM -1.09677167059948 0.0930085661288337 no 3037 0.136370608552796 954 748350 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.09885143808912 0.0925958740291156 no 3038 0.135916435734809 936 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2465 5809242 33.21 µM -1.10260743545262 0.0918539993294139 no 3039 0.135098839934295 998 2731748 SGTC_560 2332-1943 155 µM -1.10271063347549 0.0918336782521034 no 3040 0.13507642376172 932 21177716 SGTC_1007 4101-0031 70 µM -1.10450112711898 0.0914816359121828 no 3041 0.134687907445974 978 1146276 SGTC_2168 5727979 200 µM -1.10470542531113 0.0914415309789611 no 3042 0.134643625904419 961 695210 SGTC_1474 0330-0125 5.35 µM -1.10699065186378 0.090993815436779 no 3043 0.13414898501703 988 X1474 SGTC_1933 st074711 15.9 µM -1.10922400049968 0.0905578368136927 no 3044 0.133666780680188 943 17250958 SGTC_2873 9040596 71.43 µM -1.11252606504011 0.0899160751069002 no 3045 0.132956014813565 967 6463863 SGTC_1252 0493-0875 34.8 µM -1.11673660476357 0.0891026604173659 no 3046 0.132053480907733 946 3960963 SGTC_2950 9072895 21.46 µM -1.11675651489146 0.0890988271243811 no 3047 0.132049223210029 929 17332245 SGTC_2087 5276107 200 µM -1.11789934539547 0.088879003848232 no 3048 0.131804992334056 941 144405 SGTC_582 0987-0078 156 µM -1.11859782796793 0.0887448497885925 no 3049 0.131655875256993 962 1625765 SGTC_1304 1165-0502 251 µM -1.12045744682231 0.0883884173277898 no 3050 0.13125943820609 954 767425 SGTC_207 4185-0010 4.486 µM -1.12067216384465 0.0883473313883012 no 3051 0.131213717571815 943 3761753 SGTC_550 4123-0385 25.7 µM -1.12252834710698 0.0879927452775445 no 3052 0.130818930884767 976 5731123 SGTC_1503 4585-0012 61.3 µM -1.12547815458793 0.0874314293551564 no 3053 0.130193234594008 968 2922052 SGTC_2735 sertaconazole 140 nM -1.12955680304924 0.0866597157822664 no 3054 0.129331510816696 1012 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1123 mangostin 811.285 nM -1.13051308922062 0.0864795176004702 no 3055 0.129130043091003 910 5281650 An antioxidant. SGTC_1228 0124-0032 52.5 µM -1.13103337261236 0.0863815955263457 no 3056 0.129020522665371 951 X1228 SGTC_719 2810-4230 27.3 µM -1.13348216274358 0.0859218241466391 no 3057 0.128505913830256 967 721079 SGTC_3335 9143315 29.6265 µM -1.13415793274016 0.0857952682850689 no 3058 0.128364153148184 935 4899691 SGTC_1943 st076331 65.2 µM -1.13555801139556 0.0855335104946268 no 3059 0.128070795097666 962 24208415 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.13649144089925 0.0853593296902746 no 3060 0.12787547283374 990 91467 include heat shock SGTC_3083 9117465 49.47 µM -1.14002784957375 0.0847018348568008 no 3061 0.127137349371728 973 16420915 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.14518384545234 0.0837500395321934 no 3062 0.126066504400474 968 676296 Flavone; oxidizing agent. SGTC_1466 k213-0079 57.5 µM -1.14734215832633 0.0833540096455957 no 3063 0.125620118327699 989 3657981 SGTC_1321 1326-2144 215 µM -1.14934643707656 0.0829875056946296 no 3064 0.125206578529676 975 3513030 SGTC_2197 6588183 93.1375 µM -1.15298924125573 0.0823244853684334 no 3065 0.124457400239683 946 884136 SGTC_2099 5377090 177.372 µM -1.15307422026686 0.0823090662416182 no 3066 0.124439960967606 962 2243829 SGTC_1687 st020778 55.3625 µM -1.15326720009931 0.0822740588431788 no 3067 0.124400364266385 968 4259299 SGTC_367 0335-0881 7.1 µM -1.15336918950963 0.082255562040976 no 3068 0.124379441057304 977 23828853 SGTC_1554 st069299 38.7 µM -1.15545680500868 0.0818776398562444 no 3069 0.123951705722722 963 24207999 SGTC_2124 5246320 200 µM -1.15696086278215 0.0816061715098191 no 3070 0.123644175311161 948 579342 SGTC_2962 9082311 13.18 µM -1.15718000828432 0.0815666745074001 no 3071 0.123599411887325 969 16459453 SGTC_2944 9067346 25.62 µM -1.15742071301809 0.0815233084576995 no 3072 0.123550257779692 953 6473075 SGTC_1429 4049-0205 9.46 µM -1.15922508039909 0.0811987820006097 no 3073 0.12318222541769 960 22774478 SGTC_900 1112-0045 141 µM -1.1660449446436 0.0799809890135813 no 3074 0.121798137155537 941 56211 YIL048W NEO1 SGTC_1447 4239-0816 81.9 µM -1.16824773290487 0.0795906121074407 no 3075 0.121353425778709 957 1341554 SGTC_3285 9112818 20.8695 µM -1.17034980254152 0.079219430439733 no 3076 0.120930113815052 962 17017947 YPR165W RHO1 SGTC_371 0195-0006 7.36 µM -1.17303583910784 0.0787470415811795 no 3077 0.120390716983665 934 3928593 SGTC_1223 0764-0573 147 µM -1.17659025670243 0.078125217026853 no 3078 0.119679544267859 961 1609797 SGTC_3006 9075424 71.4286 µM -1.17743045277266 0.0779787753896586 no 3079 0.119511870527075 970 7465181 SGTC_3309 9129340 25.759 µM -1.17970058914685 0.0775841445451337 no 3080 0.119059659749984 965 17158987 SGTC_907 3448-6986 75.5 µM -1.18014916085498 0.0775063464797586 no 3081 0.118970447472699 974 590582 SGTC_2945 9067681 61.76 µM -1.18536625935698 0.0766058649563369 no 3082 0.117936333056819 993 16456930 SGTC_717 1532-0246 73.2 µM -1.18644614569705 0.0764204723849205 no 3083 0.117723078660951 962 9561992 SGTC_2990 9074105 71.4286 µM -1.18747413924977 0.0762443059864632 no 3084 0.117520325665051 978 6502001 SGTC_2498 4'-Methoxychalcone 54.63 µM -1.18807444193364 0.0761415756490455 no 3085 0.117402041300861 974 641818 YHR062C RPP1 SGTC_3238 9133470 49.47 µM -1.18815623931745 0.0761275857495606 no 3086 0.117385930374531 941 3534688 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.19310235066 0.0752852779315796 no 3087 0.116414645514573 957 688667 SGTC_2513 baicalein 25.65 µM -1.19563728239581 0.0748563496117043 no 3088 0.115919067920682 997 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1193 1488-0126 41.5 µM -1.19606970134829 0.0747833677830264 no 3089 0.115834680056762 952 1384710 SGTC_364 0083-0097 67.7 µM -1.1983799550439 0.0743943725500415 no 3090 0.115384566211174 1000 5207356 SGTC_126 0417-1624 672.48 µM -1.19953568437341 0.0742003541414368 no 3091 0.115159858961554 967 41912 YDL195W SEC31 SGTC_1530 rhein 70.4 µM -1.20243498783037 0.0737153336595787 no 3092 0.114597520151652 970 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1244 0416-0015 52.5 µM -1.20299072054915 0.0736226433081637 no 3093 0.114489955742316 974 96201 SGTC_3210 9128157 49.47 µM -1.2037490080426 0.0734963127344985 no 3094 0.114343301964614 967 17590849 SGTC_628 1636-0253 16 µM -1.20704030831927 0.0729499031794117 no 3095 0.113708310525673 968 4456143 SGTC_1819 st053448 58.6 µM -1.2090824196895 0.0726124458457266 no 3096 0.113315591285866 987 2857616 SGTC_1317 1273-0028 910 nM -1.20911732756282 0.0726066877574828 no 3097 0.113308886560106 955 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1839 st053978 48 µM -1.2098934579331 0.0724787545925168 no 3098 0.11315988893903 989 3788398 SGTC_1109 tnp00067 928.257 nM -1.21056074875518 0.072368900075387 no 3099 0.113031897597084 976 676295 SGTC_2838 9002687 71.43 µM -1.2140079379928 0.0718034282734719 no 3100 0.112372346466175 972 6457060 SGTC_1468 k284-1086 134 µM -1.21624295611466 0.0714386140799001 no 3101 0.111946192265082 974 15996457 SGTC_1413 3910-0535 34.4 µM -1.21633578900204 0.0714234921187203 no 3102 0.11192851671179 967 2876951 SGTC_1362 1611-0397 101 µM -1.21857257697257 0.0710598740599639 no 3103 0.111503231343872 979 27816 SGTC_1744 st037937 38.9 µM -1.21939247493951 0.0709269459595446 no 3104 0.111347632344172 1005 1016152 SGTC_891 0929-0073 133 µM -1.22031574842744 0.0707774865767966 no 3105 0.111172601020358 991 5603632 SGTC_2291 7917025 104.35 µM -1.23130047703673 0.0690177969245479 no 3106 0.109105251774632 973 2964612 SGTC_3005 9076496 71.4286 µM -1.23199419530769 0.0689078095416667 no 3107 0.108975626235557 977 21368410 SGTC_520 3584-0023 682 µM -1.23268647959128 0.0687981842607783 no 3108 0.108846379040794 971 1340790 SGTC_3311 9131146 2.8755 µM -1.23432870680761 0.0685386705496431 no 3109 0.108540221535598 979 4900406 YPR165W RHO1 SGTC_1387 3342-1166 1.8 µM -1.23786132724079 0.0679829864272407 no 3110 0.107883742012244 954 3418228 SGTC_2489 cantharidin 73.42 µM -1.23811676955111 0.0679429403979218 no 3111 0.107836383355898 963 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_633 0437-0093 97.7 µM -1.24202687407268 0.0673322191503797 no 3112 0.107113323409426 986 2831118 SGTC_613 3914-0030 117 µM -1.24897178205921 0.0662579633268342 no 3113 0.105837697440972 947 1145395 SGTC_735 3076-0345 636 µM -1.25148921411993 0.0658718552047232 no 3114 0.105378023183029 975 2888990 SGTC_2383 9036125 200 µM -1.25180111653825 0.0658241392006659 no 3115 0.105321171601665 998 79580 SGTC_1911 st060208 74.3 µM -1.25419771574057 0.0654583917319131 no 3116 0.10488507497168 997 688783 SGTC_2984 9022109 38.96 µM -1.25552932512206 0.0652558557154213 no 3117 0.104643334714391 1015 6459207 SGTC_1433 4060-0023 7.6 µM -1.25619863078786 0.0651542389861329 no 3118 0.104521981530713 983 3840627 SGTC_914 3820-6779 408 µM -1.26095612058186 0.0644354720877602 no 3119 0.103662328404566 973 2893481 SGTC_1683 st010134 710 nM -1.26473187571598 0.0638694240573662 no 3120 0.102983729651067 1002 3818134 SGTC_2023 5144124 124 µM -1.26477122760249 0.0638635449896223 no 3121 0.102976674153296 970 2830192 SGTC_2981 9013952 38.96 µM -1.26523133193947 0.0637948378439524 no 3122 0.102894206953465 984 2996344 SGTC_1265 0819-1001 68.8 µM -1.26614023777053 0.0636592803918516 no 3123 0.102731439465681 978 3106768 SGTC_2985 9022375 71.43 µM -1.26786557820622 0.063402573578675 no 3124 0.102422979204672 996 4939335 SGTC_464 bw-b 70c 158 µM -1.26972643743401 0.063126607394674 no 3125 0.102091046082122 992 5353454 SGTC_2516 gossypol 71.55 µM -1.27186450115028 0.062810687508865 no 3126 0.101710633306625 998 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2128 5255449 168.493 µM -1.27729982988388 0.0620131108453973 no 3127 0.100748206835548 966 736008 SGTC_1363 1636-0063 10.4 µM -1.28108130239452 0.0614628974043048 no 3128 0.100082555269513 980 6072185 SGTC_1328 1441-0025 69.2 µM -1.28161864569587 0.0613850230190599 no 3129 0.0999882280513596 985 4562601 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.28216821374566 0.0613054567137641 no 3130 0.099891822026524 996 66535 A nucleotide analog. SGTC_1944 st076371 56.9 µM -1.285019660779 0.0608939179587564 no 3131 0.0993927068600234 984 24208455 SGTC_712 r015-0009 80.6 µM -1.28749033382491 0.060539084296983 no 3132 0.098961718296529 996 6813872 YLR060W FRS1 SGTC_122 0236-0016 402.397 µM -1.28926603350648 0.0602850620901165 no 3133 0.0986528076107113 972 6808838 SGTC_2714 st079313 56.9 µM -1.29369874481632 0.0596545824157667 no 3134 0.0978847495405183 988 2939799 SGTC_412 gemfibrozil 100 µM -1.29408010046238 0.0596005831821608 no 3135 0.0978188771794856 985 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1349 flufenamic acid 69 µM -1.29604935280664 0.0593223501789344 no 3136 0.097479241170567 990 3371 A non-steroidal anti-inflammatory. SGTC_2725 haloperidol 53.21 µM -1.29782650424322 0.0590721340192702 no 3137 0.0971734799090848 979 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1175 0741-0056 27.6 µM -1.29854442607143 0.0589712884298368 no 3138 0.0970501603017006 997 765927 SGTC_1427 4048-4900 550 nM -1.29898203773921 0.0589098839506185 no 3139 0.0969750467929165 992 24132586 SGTC_1064 honokiol 6.76 µM -1.30113736465492 0.0586081860649519 no 3140 0.0966057200704196 1007 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_991 3996-0057 64.7 µM -1.301172947092 0.0586032155114878 no 3141 0.0965996315124158 980 715343 SGTC_954 1189-0853 2.85 µM -1.30188219151926 0.0585042093290493 no 3142 0.0964783305571771 974 2828194 SGTC_2263 7948595 193.29 µM -1.3036325771919 0.0582604282290056 no 3143 0.096179443854265 974 2971371 SGTC_2146 5545642 200 µM -1.30401764483435 0.0582069060154277 no 3144 0.0961137831574439 990 825326 SGTC_703 3875-0075 71.8 µM -1.30498517715031 0.0580725949868846 no 3145 0.0959489476001655 1032 2850814 SGTC_293 4049-0273 38.5 µM -1.30609836618785 0.0579183655914035 no 3146 0.0957595542583057 978 1380311 SGTC_2047 4141938 200 µM -1.30657558918069 0.0578523462856997 no 3147 0.0956784458044365 1000 3807862 SGTC_2322 7413319 38.22 µM -1.31477064030418 0.0567278443683965 no 3148 0.0942934987386363 967 1840400 SGTC_2455 5377712 9.75 µM -1.31505816365249 0.0566887060935349 no 3149 0.0942451777702042 970 2243908 SGTC_2666 tannic acid 100 µM -1.32028966645269 0.0559802913225701 no 3150 0.0933691621769712 981 16134267 A thiamine antagonist. SGTC_1042 0350-0096 82 µM -1.32092744749059 0.0558944069661321 no 3151 0.0932627784075022 1004 3122515 SGTC_2486 5283202 22.39 µM -1.32247209555842 0.0556868335383958 no 3152 0.0930054976903057 983 1377751 SGTC_1949 st076024 69.1 µM -1.32258568356154 0.0556715933615055 no 3153 0.0929865988978334 1000 2921930 SGTC_794 k038-0031 316 µM -1.32272439385286 0.0556529869752301 no 3154 0.0929635241047164 970 6624242 SGTC_3229 9132204 49.47 µM -1.32307576705343 0.0556058762744684 no 3155 0.0929050912643203 1016 17682924 SGTC_1034 k072-0165 12.7 µM -1.32524798903401 0.0553153319571466 no 3156 0.0925444567022726 1015 5835461 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.32677849907289 0.0551113403736345 no 3157 0.0922909824378948 999 229346 A bile salt which induces apoptosis. SGTC_3331 9141060 1.957 µM -1.32838030384359 0.0548984833465496 no 3158 0.0920262514239021 982 4906567 YPR165W RHO1 SGTC_1425 4048-4433 7.33 µM -1.32963484746246 0.0547322265254398 no 3159 0.0918193053836656 1031 23734946 SGTC_2240 6690706 185.951 µM -1.33170709087579 0.0544584771008091 no 3160 0.0914782291318838 994 805876 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.33303113867377 0.0542841343035336 no 3161 0.0912607926802455 994 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1713 st033146 12.748 µM -1.33352956446361 0.0542186190590041 no 3162 0.091179040053697 1012 674619 SGTC_1998 st075797 76.8 µM -1.33759623664036 0.0536864131878448 no 3163 0.0905140459505492 981 24208315 SGTC_246 cycloheximide 667 µM -1.34000245711808 0.0533734645698677 no 3164 0.0901222730481443 1002 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1594 piperine 70.1 µM -1.34114577628927 0.0532252741158157 no 3165 0.0899365636839183 999 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1089 terbinafine 2.25 µM -1.34185079317486 0.0531340565795006 no 3166 0.089822189611552 994 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1926 methyl fluorone black 53.6 µM -1.345572927982 0.0526545266759603 no 3167 0.0892201436411198 935 72721 Reacts with homocysteine. SGTC_2423 st077119 87.2 µM -1.3457375644904 0.0526333958048385 no 3168 0.089193583609604 986 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_3254 9136651 49.47 µM -1.34672020121287 0.0525074156371671 no 3169 0.0890351818023471 1025 16454030 SGTC_262 fenpropimorph 62.5 µM -1.3502569693446 0.0520559599164599 no 3170 0.0884667849871926 1030 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_390 dec-rvkr-cmk 16.7 µM -1.35409777224162 0.0515691936345938 no 3171 0.08785259342722 1000 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1331 1472-0049 76.2 µM -1.35665844172407 0.051246681464444 no 3172 0.0874448815225817 998 24051409 SGTC_555 4296-0685 37 µM -1.35974819605368 0.050859670494648 no 3173 0.0869548103960126 1019 2908540 YHR072W ERG7 SGTC_748 act1.228 77.9 µM -1.36852954092313 0.0497724468404119 no 3174 0.085573190875564 1001 4421505 YNR035C ARC35 SGTC_1947 st076332 61.6 µM -1.37263641732738 0.0492703754095794 no 3175 0.0849327023205038 1006 24208416 SGTC_2931 9014674 55.67 µM -1.37809177667582 0.0486097130793895 no 3176 0.0840874770839777 1019 2996810 SGTC_1574 spiramycin 23.7 µM -1.38171978402617 0.0481742839907963 no 3177 0.0835288786675728 999 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1711 st032263 62.8 µM -1.38296849218974 0.0480251394794991 no 3178 0.0833372635633192 1012 3958979 SGTC_1478 0453-0656 35.7 µM -1.38701644073774 0.0475441956660759 no 3179 0.0827183748152649 1033 5258496 SGTC_2607 solasodine 47.35 µM -1.38740364052973 0.0474983946800291 no 3180 0.0826593577618933 1001 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2381 9035592 200 µM -1.38999783792303 0.0471924440168959 no 3181 0.082264766948039 1018 4749657 SGTC_308 4092-1169 104 µM -1.3907950472718 0.0470987418701435 no 3182 0.0821437927028825 1007 2268590 YDL196W YDL196W SGTC_1303 1160-0052 261 µM -1.39200229313639 0.0469571290077882 no 3183 0.081960851776664 987 3562476 SGTC_777 1315-0167 517 µM -1.3973160539186 0.0463378663813078 no 3184 0.0811592751413786 985 4221767 SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.40081798916659 0.0459333494846479 no 3185 0.0806342539043351 1019 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2120 5538279 151.968 µM -1.40248887369351 0.0457413440010091 no 3186 0.0803846553536019 1021 2058197 SGTC_1772 st048439 82.2 µM -1.40491747494509 0.0454634182231214 no 3187 0.0800229097694827 988 2927068 YDL195W SEC31 SGTC_642 0335-0876 158 µM -1.40690979426484 0.0452364353432202 no 3188 0.0797270694697765 1014 6812350 SGTC_3066 9117245 49.47 µM -1.41353398351641 0.0444882965319722 no 3189 0.0787493882626682 988 17176980 SGTC_2635 hydroquinidine 100 µM -1.41373454585252 0.0444658013601448 no 3190 0.0787199290804072 997 442912 An experimental heart treatment. SGTC_422 cantharidin 155 µM -1.41516290526432 0.0443058607797391 no 3191 0.0785103689423334 1010 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_47 0149-0135 24.25 µM -1.41543636440597 0.044275293130505 no 3192 0.0784702969693546 1015 5239155 SGTC_578 3460-0051 92 µM -1.41594323595188 0.0442186792669969 no 3193 0.0783960623742553 1027 2876744 SGTC_1082 camptothecin 424.86 nM -1.41753850477183 0.0440408800882303 no 3194 0.0781627725020884 967 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_428 3448-4153 16.5 µM -1.41786039907979 0.0440050736525713 no 3195 0.078115763042059 999 3834874 SGTC_2979 9012552 45.46 µM -1.41994819847791 0.0437734034598708 no 3196 0.0778113812473775 1020 17100905 SGTC_847 0342-0274 5.54 µM -1.42695619672327 0.0430029553478397 no 3197 0.0767962604774173 1015 18097 SGTC_1864 st057645 30.4 µM -1.43020778435558 0.0426492210355786 no 3198 0.0763286959658938 1013 688666 SGTC_868 0527-0199 213 µM -1.43581011494153 0.0420452749037894 no 3199 0.0755281903996645 1007 2849450 SGTC_980 1473-0395 201 µM -1.43621390253574 0.0420020143396523 no 3200 0.0754707421111956 1014 768876 SGTC_1062 mesoridazine 14.2 µM -1.43831668113706 0.0417773111473738 no 3201 0.0751721104844691 1001 4078 A neuroleptic. SGTC_1712 st032288 53.4 µM -1.43942527499411 0.0416592391615578 no 3202 0.0750150337608214 1013 2883011 SGTC_2801 7907800 81.82 µM -1.44675017266078 0.0408858706547153 no 3203 0.0739834533746074 994 6620925 SGTC_94 0334-0113 514.748 µM -1.45263633467028 0.0402728804533387 no 3204 0.0731623760855196 1012 6795178 SGTC_1764 st044502 93.5 µM -1.45765836644478 0.0397558017530958 no 3205 0.0724673665247804 1015 8407 SGTC_1278 0874-0585 172 µM -1.46116585357054 0.0393978750223335 no 3206 0.071984965710186 1027 766306 SGTC_209 4077-0173 175.592 µM -1.46855741460407 0.0386521749060575 no 3207 0.0709764363201876 1024 15993494 SGTC_1163 k060-0048 49.9 µM -1.47422802226457 0.0380879229920343 no 3208 0.0702101036859046 1031 6809982 SGTC_2224 6650123 117.647 µM -1.47748229751694 0.0377671534601168 no 3209 0.0697732000607759 1047 2908370 SGTC_9 0092-0002 10.449 µM -1.4794199592554 0.0375772103189868 no 3210 0.0695140544730748 1018 759368 SGTC_1213 1315-0166 115 µM -1.4829773417649 0.037230521623165 no 3211 0.0690402154366167 1008 768401 SGTC_1959 st077091 55.8 µM -1.4834720544028 0.0371825164994039 no 3212 0.0689745179420024 1011 821356 YKL052C ASK1 SGTC_830 4076-0286 57.8 µM -1.48358458168439 0.03717160432308 no 3213 0.0689595811261579 1025 6866659 SGTC_1481 3346-2004 36 µM -1.48582955148244 0.036954447863169 no 3214 0.0686621057268917 1034 2770522 SGTC_162 k030-0015 37.8 µM -1.49225900064734 0.0363382584967335 no 3215 0.0678156302065383 1035 1809920 YMR134W ERG29 SGTC_1168 k815-0004 80.5 µM -1.49619010074906 0.0359656680269546 no 3216 0.0673020617436938 1027 642433 SGTC_202 3594-0513 34.79 µM -1.49846066127276 0.0357518933761993 no 3217 0.0670068029932593 1038 708429 SGTC_121 0557-0495 61.343 µM -1.5010502230739 0.0355093567028454 no 3218 0.0666712860105216 1029 3104427 SGTC_3352 9151559 45.5865 µM -1.50220487089098 0.035401648824291 no 3219 0.0665221036359705 1022 17159339 SGTC_2484 5809818 12.04 µM -1.51299846889342 0.0344077029017516 no 3220 0.0651400238874902 1017 2870548 SGTC_924 2046-0044 21.3 µM -1.51445043284783 0.0342757633884381 no 3221 0.0649558181827051 1016 3623589 SGTC_1164 k060-0068 93.7 µM -1.51513334974856 0.0342138508849891 no 3222 0.0648693187860257 1023 5963676 SGTC_841 0251-0215 91.2 µM -1.52152267709056 0.0336390434719244 no 3223 0.0640643624914587 1041 3888614 SGTC_823 0417-1665 178 µM -1.52168669516325 0.033624393077575 no 3224 0.0640438014585333 1036 3429856 SGTC_626 0214-0009 33 µM -1.53052813743138 0.0328423964641781 no 3225 0.0629430271067475 1025 3437874 SGTC_2706 st078239 82.5 µM -1.53098506878789 0.0328023932483999 no 3226 0.062886541448787 1034 15434492 SGTC_2367 9070478 135.38 µM -1.5327473029981 0.0326484900053595 no 3227 0.0626690646101359 1013 572802 SGTC_1621 st003705 32.4 µM -1.53468005426708 0.0324803800015259 no 3228 0.062431218790277 1012 24207032 SGTC_660 4031-1742 102 µM -1.5372646879037 0.0322566861186455 no 3229 0.0621142525302362 995 6738706 SGTC_1763 st044482 94.5 µM -1.5399712117216 0.0320238073501651 no 3230 0.0617836854340557 1023 88505 SGTC_1165 k072-0275 30.3 µM -1.54013782175561 0.0320095171191016 no 3231 0.0617633811181992 1026 6153523 YGL055W OLE1 SGTC_772 k072-0172 35.3 µM -1.54373196745038 0.0317025251671789 no 3232 0.0613266393052177 1001 5861980 SGTC_405 ebelactone b 50 µM -1.5491895473897 0.0312410239781739 no 3233 0.0606680807149561 1019 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2116 5511452 16.8835 µM -1.56191058121976 0.0301868560705311 no 3234 0.0591545277122882 1028 870744 SGTC_2203 7227154 166.4 µM -1.56627768042162 0.0298318316668127 no 3235 0.0586418119302068 1035 896304 SGTC_1342 1486-1464 234 µM -1.57035669175003 0.0295033627057458 no 3236 0.0581660759689082 1025 3253938 SGTC_78 0336-0123 156.75 µM -1.57150891868825 0.0294111234784199 no 3237 0.058032242209869 1021 6765896 SGTC_2762 leflunomide 42.06 µM -1.57245354497601 0.0293356820342649 no 3238 0.0579227023597077 1040 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_583 1488-1091 88.9 µM -1.57401709293551 0.0292111643134381 no 3239 0.0577417489155621 1054 4303273 SGTC_106 0092-0003 11.579 µM -1.57732374103987 0.0289492753652702 no 3240 0.057360526181248 1024 1072148 SGTC_3317 9138495 8.753 µM -1.58476434480405 0.0283671046866236 no 3241 0.0565099431197272 1033 17020139 SGTC_2244 6635614 200 µM -1.58501628575676 0.0283475640031024 no 3242 0.056481317057761 1042 836499 SGTC_322 k048-0136 19.3 µM -1.58844771667542 0.0280825337235573 no 3243 0.0560925673855969 1039 6823282 SGTC_2497 7-hydroxyflavone 100 µM -1.59328738091877 0.0277122468742522 no 3244 0.0555478681353191 1030 5281894 SGTC_2304 7443016 91.4 µM -1.60129613283532 0.0271084319198859 no 3245 0.0546556725748849 1032 939854 SGTC_1287 0971-0001 34.6 µM -1.60146807012172 0.0270955901541131 no 3246 0.0546366432929427 1024 4665869 SGTC_2987 9018338 71.43 µM -1.60836080689076 0.0265849463717449 no 3247 0.053878090117309 1027 5055682 SGTC_1515 3460-0031 42.1 µM -1.60873767163245 0.0265572599800158 no 3248 0.0538368573816234 1024 2876596 SGTC_880 0833-0487 87.2 µM -1.62524878790007 0.0253677061107408 no 3249 0.0520547793405779 1038 76075 SGTC_272 doxorubicin 8.13 µM -1.62825335643562 0.0251561129072843 no 3250 0.0517355876557731 1046 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_144 4161-2749 112.381 µM -1.62855248007363 0.0251351286719539 no 3251 0.0517038954608432 1020 797501 YMR168C CEP3 SGTC_1112 tnp00069 1.16933 µM -1.63329212686185 0.0248045843199477 no 3252 0.0512037859304747 1037 145826 SGTC_2033 5192550 145 µM -1.63840693215976 0.0244519743754829 no 3253 0.0506684170182312 1019 182073 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.64122222589134 0.0242596925159116 no 3254 0.0503756468249336 1009 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1488 4013-0813 75.9 µM -1.64137538688181 0.0242492682896115 no 3255 0.0503597579340892 1031 2910057 SGTC_1367 1812-0510 76.9 µM -1.65547335140968 0.0233057317625666 no 3256 0.0489142588266274 1038 1142582 YDR527W RBA50 SGTC_1648 st011736 69.8 µM -1.66266905213043 0.0228361775365341 no 3257 0.0481893501918149 1048 2855514 SGTC_1190 1486-1332 13 µM -1.66695015035312 0.0225606157789324 no 3258 0.0477621587880216 1026 4150046 SGTC_2313 7726885 200 µM -1.66883217351073 0.0224403655479254 no 3259 0.0475753222903107 1033 726423 SGTC_870 0573-2213 57.6 µM -1.67144921193402 0.022274050937763 no 3260 0.0473164912239912 1036 3916321 SGTC_1204 4049-0315 18.3 µM -1.68721546697304 0.0212939508641318 no 3261 0.0457809641939331 1027 588402 SGTC_2105 5350118 200 µM -1.68939757600201 0.0211612181664924 no 3262 0.0455716326119891 1038 2133313 SGTC_2671 danthron 100 µM -1.69167163435327 0.0210236378362013 no 3263 0.0453542998649385 1049 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2189 6047310 154.431 µM -1.70270361480194 0.0203669000101555 no 3264 0.0443117740319456 1039 711535 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.70367103843432 0.0203101473694279 no 3265 0.0442212808513812 1034 6708514 SGTC_965 1291-5240 308 µM -1.70796444803133 0.0200598950912624 no 3266 0.0438214696971575 1044 2834598 SGTC_420 mitomycin C 81.9 mM -1.70947062622816 0.019972725619561 no 3267 0.0436819041220377 1029 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2971 9092186 9.93 µM -1.71067436257521 0.0199032910955842 no 3268 0.0435706214859673 1034 25236400 SGTC_3135 9127742 49.47 µM -1.7184495085685 0.019459717882089 no 3269 0.0428573282893291 1031 3643468 SGTC_526 4469-0568 170 µM -1.72214338644212 0.0192519416403429 no 3270 0.0425217736687737 1032 2901964 SGTC_1613 st002381 52.1 µM -1.74040439841988 0.0182522727867722 no 3271 0.0408940168760793 1044 551167 SGTC_2161 5662504 8.5105 µM -1.74304806302719 0.0181112804149901 no 3272 0.0406626098286203 1011 2859334 SGTC_753 1322-0200 289 µM -1.7471199275442 0.0178959355697322 no 3273 0.0403082686996474 1064 5403907 SGTC_666 0272-0154 136 µM -1.76426535446026 0.0170129783013384 no 3274 0.0388436570314779 1069 6870312 SGTC_2721 ifenprodil 61.44 µM -1.76826915873412 0.0168122388631997 no 3275 0.0385079586346581 1039 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_55 0767-0285 6.563 µM -1.77985529855781 0.0162427184787712 no 3276 0.0375498224706867 1036 3116166 SGTC_1669 st015249 58.4 µM -1.78120816448507 0.0161773080846661 no 3277 0.0374392251858759 1080 722793 SGTC_392 N-ethylmaleimide 8.33 µM -1.80249796556636 0.0151773018433515 no 3278 0.0357335472488176 1045 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2098 5376439 882.5 nM -1.81930931308385 0.0144256246201036 no 3279 0.0344321266733198 1049 2844116 SGTC_630 4356-0227 183 µM -1.82542647688005 0.0141601782590777 no 3280 0.0339683484136384 1056 779312 SGTC_2264 7948757 110.76 µM -1.82587170650595 0.0141410234661937 no 3281 0.0339347944718866 1055 2971411 SGTC_1578 josamycin 24.2 µM -1.828198680824 0.0140412745986145 no 3282 0.0337598694699695 1049 5282165 A P450 substrate. SGTC_2029 5175081 200 µM -1.84484533971878 0.01334522273505 no 3283 0.0325300199190138 1059 1380876 SGTC_470 aa-861 153 µM -1.85256169251329 0.0130328175220212 no 3284 0.0319726036984127 1048 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1316 1272-0050 65.9 µM -1.85525503839613 0.0129252728688511 no 3285 0.0317799077380336 1064 7340392 SGTC_1925 st057770 10.1 µM -1.8642801577539 0.0125704773475585 no 3286 0.0311411858943002 1049 5989122 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.87123206840828 0.0123029618399072 no 3287 0.0306564608340956 1043 6857784 SGTC_1006 4099-6547 255 µM -1.87458726858469 0.012175625144535 no 3288 0.0304247630094689 1057 3146833 SGTC_1300 1094-0077 113 µM -1.88277438125114 0.0118696918455418 no 3289 0.0298654751577374 1063 5532636 SGTC_1325 1431-0015 227 µM -1.89780216116017 0.0113254659359082 no 3290 0.0288610742143813 1063 1103340 SGTC_574 1315-0397 40 µM -1.90200074860006 0.0111773455339033 no 3291 0.0285855283646877 1062 6794277 SGTC_651 3253-0966 34.4 µM -1.90644679977187 0.0110223338960323 no 3292 0.0282961308742004 1069 781462 SGTC_66 0109-0187 42.4 µM -1.90849995738343 0.0109513839710706 no 3293 0.0281633143351084 1043 759417 SGTC_3078 9116413 49.47 µM -1.91207290008117 0.0108288627788206 no 3294 0.0279334221183365 1046 17177322 SGTC_2802 7925815 54.55 µM -1.91321830892377 0.0107898384901989 no 3295 0.0278600552882044 1051 1262923 SGTC_2333 9017922 200 µM -1.91781285152216 0.0106345295122025 no 3296 0.0275673728091928 1047 3163164 SGTC_215 1287-0124 461.5 µM -1.92230096160327 0.010484701908612 no 3297 0.0272839495391241 1072 5560863 SGTC_1195 1502-0147 41.1 µM -1.92882615910523 0.0102701520730615 no 3298 0.0268762235887716 1056 817940 SGTC_1765 st044815 90.4 µM -1.93047035639513 0.0102166982416305 no 3299 0.0267742923813514 1054 645695 SGTC_573 3702-0553 84.7 µM -1.93229106886009 0.0101577890865983 no 3300 0.0266617950744066 1062 1222756 SGTC_995 3931-2021 34.6 µM -1.93274853289988 0.010143034498538 no 3301 0.026633591650652 1064 730143 SGTC_1299 1079-1439 3.74 µM -1.96120578024644 0.00926120146253168 no 3302 0.024927511431734 1064 323161 SGTC_253 dyclonine 31.25 µM -1.98922772603287 0.00845916451299314 no 3303 0.0233380364503694 1072 3180 An oral anasthetic. SGTC_1124 fisetin 1.16336 µM -2.0078018157896 0.00796174920879565 no 3304 0.0223321779101118 1064 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1623 st003709 20.3 µM -2.01760660754341 0.00770969481445275 no 3305 0.021816124088528 1065 16192618 SGTC_2784 7567673 72.73 µM -2.0256010406058 0.00750940510367677 no 3306 0.0214028424113874 1047 3471247 SGTC_458 nppb 133 µM -2.0319688332029 0.00735316258376512 no 3307 0.0210784056202638 1074 4549 A chloride channel blocker. SGTC_1740 st038286 13.222 µM -2.04014600571174 0.00715673098179793 no 3308 0.0206678928515879 1054 716786 SGTC_1761 st044296 37 µM -2.04306070881369 0.00708784149888591 no 3309 0.0205232144012832 1070 1826700 SGTC_3212 9128307 49.47 µM -2.0446385756287 0.00705079301299969 no 3310 0.0204452517242105 1056 27243542 SGTC_1897 st060201 15 µM -2.04850062070398 0.00696083194836005 no 3311 0.0202554856694683 1069 611878 SGTC_805 3852-0218 479 µM -2.06918863587671 0.00649597590393104 no 3312 0.0192641943503605 1064 6615355 SGTC_1290 0986-0249 10.2 µM -2.06925348565905 0.00649456299580201 no 3313 0.0192611530136608 1059 53329 SGTC_1857 st056007 79.3 µM -2.07000706216768 0.00647816444534717 no 3314 0.0192258415606327 1076 619834 SGTC_1288 0973-0013 65.5 µM -2.07678832447467 0.00633223777874478 no 3315 0.018910550146604 1072 4315430 SGTC_2433 5607874 27.82 µM -2.07877085418804 0.00629012883520648 no 3316 0.0188192084903585 1048 2252428 SGTC_867 0518-0118 155 µM -2.10468966616246 0.0057619877415005 no 3317 0.0176591653017966 1063 6848158 SGTC_386 1509-0011 3.07 µM -2.11540934007409 0.00555531905280255 no 3318 0.0171975372155022 1061 3107280 SGTC_523 1934-0222 13.7 µM -2.1157011075215 0.00554978720160802 no 3319 0.0171851181653211 1076 1361595 SGTC_741 4582-0002 126 µM -2.12087243376271 0.00545254859671754 no 3320 0.0169662695159727 1070 2912688 SGTC_2569 tetrandrine 100 µM -2.13184321493511 0.00525125883080114 no 3321 0.0165098688449839 1066 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_473 2-arachidonoylglycerol 10 µM -2.13504141474021 0.00519383679884834 no 3322 0.0163788136861155 1036 5282280 An endocannabinoid. SGTC_1459 k035-0031 35.7 µM -2.14741990057538 0.00497681850739969 no 3323 0.0158799338682925 1050 3877128 YMR208W ERG12 SGTC_614 0462-0418 107 µM -2.15245361219473 0.00489090371110029 no 3324 0.0156808225313814 1049 5188303 SGTC_313 3474-0040 5.03 µM -2.17326587623332 0.00454954682661832 no 3325 0.0148801561028975 1080 1043375 YIL048W NEO1 SGTC_401 neomycin 50 µM -2.17846208468333 0.00446770949217114 no 3326 0.0146858260277228 1059 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_625 k213-0058 121 µM -2.18694817280592 0.00433688256044102 no 3327 0.0143731538356279 1070 3655420 SGTC_244 nsc-207895 1.295 µM -2.19777634967351 0.00417492555502973 no 3328 0.0139825238024893 1068 42640 SGTC_1781 st038725 66.3 µM -2.1978977210696 0.00417314128352033 no 3329 0.0139781976746177 1073 4270275 YIL048W NEO1 SGTC_125 0133-0007 11.75 µM -2.2021175593133 0.00411152838646442 no 3330 0.0138285027206975 1072 26541 SGTC_1394 3474-0001 65.7 µM -2.25806592039488 0.00336821302675276 no 3331 0.011970774969969 1083 5017666 YIL048W NEO1 SGTC_1892 st058411 7.36 µM -2.2730006931183 0.00319139319323044 no 3332 0.0115130690855292 1083 3934738 SGTC_2118 5526350 200 µM -2.27952987087494 0.00311674991997726 no 3333 0.0113177931966369 1079 743594 SGTC_2432 5630864 12.22 µM -2.29372360858311 0.00295987939269265 no 3334 0.01090318988851 1077 5714970 SGTC_1848 st056003 16.4 µM -2.30271717160579 0.00286420118341892 no 3335 0.0106473807030754 1066 146492 SGTC_1107 amlodipine 47 µM -2.32046998095652 0.00268348245884472 no 3336 0.0101577335053235 978 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1199 1638-0010 4.46 µM -2.32164998707028 0.00267184339284764 no 3337 0.0101258949847583 1076 3111136 SGTC_1565 sinapyl alcohol 95.1 µM -2.32585884901511 0.00263069938273825 no 3338 0.0100130409805866 1062 5280507 A phenol propionate derived from cinnamic acid. SGTC_1694 st024011 44.9 µM -2.33131292200547 0.00257823435772496 no 3339 0.00986843266997842 1084 2787533 SGTC_1504 k297-0033 30 µM -2.34073465333703 0.00248982605126869 no 3340 0.00962292000672323 1055 4388117 SGTC_1847 st056231 15 µM -2.40016701763631 0.00199255426054824 no 3341 0.00819379639262874 1076 5393180 SGTC_2403 6032726 181.2 µM -2.42530009119793 0.00181085272302461 no 3342 0.00764786862087981 1080 2881040 SGTC_2502 avocadyne acetate 18.59 µM -2.45425718586954 0.0016202726161875 no 3343 0.00705879857435844 1069 3952079 SGTC_2507 purpurin 79.67 µM -2.45974055972974 0.00158631191898616 no 3344 0.00695187418908898 1079 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_59 0330-0160 1.33 µM -2.53739641177771 0.00117016429905337 no 3345 0.00558402069800757 1083 4293482 SGTC_71 0417-1750 47.813 µM -2.54532021558459 0.00113388253605695 no 3346 0.005458878414797 1063 6811472 SGTC_1571 st070080 73.4 µM -2.57314612625789 0.00101448460611983 no 3347 0.00503893239130887 1084 4315245 SGTC_1471 k673-0312 37 µM -2.6142361245942 0.000859152960674578 yes 3348 0.00447136045592489 1089 24099884 SGTC_1684 st024538 14.6195 µM -2.73052916886368 0.000530276330636301 yes 3349 0.00316163685886287 1092 6732859 SGTC_736 0958-0254 92.6 µM -2.78499386438727 0.000420391501422487 yes 3350 0.00267643679736642 1092 6812352 SGTC_2339 9000433 200 µM -3.09878200726744 0.000102076090297338 yes 3351 0.000971589695401378 1088 2988954 SGTC_2265 7929201 200 µM -3.23727796642665 5.23887700227012e-05 yes 3352 0.000603379025983574 1087 1265108 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -3.46659942982904 1.63947472822444e-05 yes 3353 0.000263543373980756 1089 6708739 YPR165W RHO1 SGTC_1389 3405-0187 19 µM -3.55074425437498 1.05141087596502e-05 yes 3354 0.000192071749946498 1094 799890 SGTC_1896 st058441 89 µM -3.95863560542844 1.06383702759699e-06 yes 3355 3.76895695651006e-05 1092 688759 SGTC_750 4073-0104 132 µM -5.27011681579676 1.41838532552524e-10 yes 3356 6.81684814474894e-08 1090 22330957