SGTCid condition conc unit ATP16|YDL004W.score ATP16|YDL004W.strain.pval ATP16|YDL004W.strain.significant ATP16|YDL004W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2013 4024628 200 µM 11.8762519327892 3.71613062720924e-32 yes 1 7.86309538141334e-33 1 5230760 SGTC_236 1509-0011 5.31 µM 9.40774388725961 6.16378832800532e-21 yes 2 2.53450076465208e-21 3 3107280 SGTC_3205 9113483 49.47 µM 7.77649036454809 6.4484815631566e-15 yes 3 3.72821302380622e-15 1 17018033 SGTC_1923 st058458 19.1 µM 6.8599337042958 5.09102343115753e-12 yes 4 3.44462560213248e-12 2 3534982 SGTC_971 1315-0384 26.7 µM 5.72241299777278 6.60645460079598e-09 yes 5 5.25108144780105e-09 2 6769120 SGTC_2019 4016004 108 µM 5.16975447379923 1.38217872640313e-07 yes 6 1.17200875426808e-07 4 45595336 SGTC_120 rhodamine 6G 52.259 µM 4.56312363535371 2.79639492450744e-06 yes 7 2.51990577645597e-06 12 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2346 9031566 143.75 µM 4.5542377506568 2.91486075601272e-06 yes 8 2.62879339222803e-06 10 4771086 SGTC_2763 lisinopril 49.32 µM 4.32735181482923 8.20126270318604e-06 yes 9 7.54564046725984e-06 1 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1381 2324-0066 62.1 µM 4.30887471317866 8.90330130163552e-06 yes 10 8.20436415899413e-06 7 10885928 SGTC_2761 levamisole 97.89 µM 4.24359139900363 1.1870738042774e-05 yes 11 1.09985360100453e-05 3 26879 An alkaline phosphatase inhibitor. SGTC_1469 k284-2957 126 µM 4.03860818897956 2.85475756169267e-05 yes 12 2.68846462105546e-05 12 23884841 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 3.9547224257518 4.04250150178476e-05 yes 13 3.83117792931464e-05 2 2374 Ca(2+)-ATPase inhibitor. SGTC_655 k060-0012 42 µM 3.93555963687142 4.37286972447023e-05 yes 14 4.15015244051386e-05 6 5994525 SGTC_1744 st037937 38.9 µM 3.88216470928607 5.43313912354745e-05 yes 15 5.17653556970524e-05 8 1016152 SGTC_1278 0874-0585 172 µM 3.79933482568677 7.56920609019373e-05 yes 16 7.25424851440059e-05 6 766306 SGTC_87 0100-0052 35.5 µM 3.79497529266134 7.70110915425571e-05 yes 17 7.38290799556594e-05 19 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_59 0330-0160 1.33 µM 3.789203808572 7.87906278796006e-05 yes 18 7.55654434688142e-05 5 4293482 SGTC_2663 amphotericin b 100 µM 3.71853340026427 0.000103962848850032 yes 19 0.000100191400166808 7 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1245 0418-0076 17.2 µM 3.65282575898882 0.000133979013296714 yes 20 0.000129685118561395 10 6790114 SGTC_3148 9097893 49.47 µM 3.6400084093311 0.000140709755795591 yes 21 0.000136314568490581 11 17174100 SGTC_1702 st027038 51 µM 3.55140744027765 0.000196645880297644 yes 22 0.000191588370248585 4 5521182 SGTC_695 3505-6186 243 µM 3.5471654332503 0.000199786421846573 yes 23 0.000194699994474152 15 1819379 SGTC_1969 st069479 40.1 µM 3.49642456292669 0.000241168063432539 yes 24 0.000235768899355469 4 3895485 SGTC_2870 9038528 12.99 µM 3.38523235481542 0.000361324282721855 yes 25 0.000355590132197736 9 6463316 SGTC_2981 9013952 38.96 µM 3.37929301713604 0.000369094573070937 yes 26 0.000363362534374857 17 2996344 SGTC_2066 5222451 176 µM 3.30842212685052 0.000474593610822146 yes 27 0.000469116367706098 36 2281147 SGTC_98 0074-0023 107.663 µM 3.22243079729462 0.00063993244701756 yes 28 0.000635539330961996 6 3563821 SGTC_746 1095-0025 46.6 µM 3.16578640224412 0.000776336983622346 yes 29 0.000773321599413483 16 6749286 SGTC_3203 9113543 49.47 µM 3.07792186892148 0.00104164141364078 no 30 0.00104224779692441 21 17018012 SGTC_1533 dihydroergotamine mesylate 29.4 µM 3.065339991402 0.00108580401206261 no 31 0.00108711340715898 23 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_451 chloral hydrate 100 µM 3.0524177072097 0.00113294243919242 no 32 0.00113502982791399 35 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2047 4141938 200 µM 3.03758590853897 0.00118935298082881 no 33 0.00119240708428844 9 3807862 SGTC_3251 9135047 49.47 µM 3.03558738430291 0.00119714760183015 no 34 0.00120033823322138 10 17682963 SGTC_1590 st077108 57.8 µM 3.02084206987385 0.00125611811464145 no 35 0.00126036399957481 15 5489485 SGTC_979 1426-2828 121 µM 3.01065757263646 0.00129838746515198 no 36 0.00130341325446426 9 747872 SGTC_2779 methotrexate 400 µM 3.00514473625867 0.00132180645472473 no 37 0.00132727249339011 30 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_58 0957-0393 9 µM 3.00211189343576 0.00133485424755296 no 38 0.00134056803415716 69 6997992 SGTC_63 0099-0242 26.702 µM 2.99845576616484 0.00135073994989095 no 39 0.00135675771634428 37 3898502 YLR359W ADE13 SGTC_1189 1431-2119 7.28 µM 2.9953566844633 0.00136434038374601 no 40 0.00137062042383621 17 3107275 SGTC_594 1487-1584 10.8 µM 2.96962215056407 0.00148220312296821 no 41 0.00149083122186541 19 5013332 SGTC_2791 5663188 71.43 µM 2.95383927593928 0.00155901007105712 no 42 0.00156923706600923 27 54690634 SGTC_1850 st056238 17 µM 2.94410659012001 0.00160816510073765 no 43 0.00161944215196836 14 5393177 SGTC_3062 9077494 49.47 µM 2.93897104185617 0.00163466763206882 no 44 0.00164651920073314 15 16459633 SGTC_2914 7968218 45.32 µM 2.93182713564899 0.00167219640095112 no 45 0.00168487128027139 6 2977111 SGTC_1863 st057641 20.1 µM 2.87110277179806 0.00202430276659796 no 46 0.00204521257652705 19 3921635 SGTC_393 acivicin 6.25 µM 2.85013190096212 0.00216073147265826 no 47 0.00218505510074493 26 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_381 3461-2219 42.7 µM 2.84241327443079 0.00221300900052444 no 48 0.00223867053556848 14 2883159 SGTC_1530 rhein 70.4 µM 2.83656058660962 0.00225340991736197 no 49 0.00228011626405109 15 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2828 7998861 71.43 µM 2.83277839353514 0.00227987250419023 no 50 0.00230726822852248 9 2988188 SGTC_1666 st014829 29 µM 2.80842291116179 0.00245712805742012 no 51 0.00248924000636148 16 3858230 SGTC_3186 9110464 49.47 µM 2.80277947270426 0.00249993923540674 no 52 0.00253321496611683 9 17018021 SGTC_701 4424-0219 185 µM 2.78191622778039 0.00266412636037656 no 53 0.00270194934458692 17 2911779 SGTC_754 3474-0146 171 µM 2.78133574679603 0.0026688306967415 no 54 0.002706785872249 18 24762078 SGTC_760 0568-0725 82.9 µM 2.78130086994187 0.00266911358464929 no 55 0.00270707671256801 12 3916171 SGTC_2099 5377090 177.372 µM 2.7788201417434 0.00268930449309738 no 56 0.0027278361800862 14 2243829 SGTC_1700 st030840 7.9285 µM 2.77293528943708 0.00273775465804402 no 57 0.00277765832287086 29 5499307 SGTC_2732 terfenadine 20 µM 2.7645694153037 0.00280798761977912 no 58 0.00284989892312458 14 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_941 3237-0776 460 µM 2.74744392547912 0.00295685126594515 no 59 0.00300308891757217 12 760008 SGTC_1143 3454-2408 5.08 µM 2.73512901775039 0.00306825576743996 no 60 0.00311779151745286 15 X1143 SGTC_559 1550-0661 158 µM 2.71306524200396 0.0032773418714613 no 61 0.00333319900941034 16 5830875 SGTC_1737 st035557 69.7 µM 2.68482325808071 0.00356363712307391 no 62 0.00362840849023051 26 5716916 SGTC_3116 9124943 49.47 µM 2.68137819695703 0.00360005460982371 no 63 0.0036659800246863 21 41905195 YPL160W CDC60 SGTC_1429 4049-0205 9.46 µM 2.67167108318998 0.00370447106574549 no 64 0.00377372939294095 12 22774478 SGTC_2080 5212524 12.4 µM 2.67094234499141 0.00371241843362229 no 65 0.00378193187144878 25 260183 SGTC_429 1112-0049 25.5 µM 2.66086644619058 0.00382388098054685 no 66 0.00389699325671767 31 2836170 SGTC_1845 st056753 3.01 µM 2.65444211090945 0.00389650573111579 no 67 0.00397198343940007 30 5375839 SGTC_1616 st002734 56.1 µM 2.64916448168735 0.00395708940531493 no 68 0.00403455246588631 25 4026101 SGTC_1142 3253-1408 9.78 µM 2.63783737126221 0.00408997395920559 no 69 0.00417182924708042 11 256655 SGTC_2783 7738165 71.43 µM 2.6267076789547 0.00422441829157864 no 70 0.00431076818513997 27 17201110 SGTC_2848 9016370 25.97 µM 2.62433211350394 0.00425362137736771 no 71 0.00434095412542383 15 7894410 SGTC_511 blebbistatin 171 µM 2.59460600832235 0.0046346108066847 no 72 0.00473497025585906 23 3476986 A myosin inhibitor. SGTC_983 1491-0821 12.2 µM 2.59432053744483 0.00463841267775259 no 73 0.00473890396061482 24 46495113 SGTC_1478 0453-0656 35.7 µM 2.59081204111916 0.00468536626035836 no 74 0.00478748859162575 25 5258496 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 2.57491288597206 0.00490349867965467 no 75 0.00501326681304017 22 75037 A free radical scavenger. SGTC_1835 st008666 49.2 µM 2.57379073037449 0.00491923093230529 no 76 0.00502955475213593 10 690455 SGTC_923 1900-2434 73.3 µM 2.55768738033038 0.00515000038642001 no 77 0.00526853859480274 38 5910570 SGTC_2628 lathosterol 100 µM 2.55135255719838 0.00524339057264153 no 78 0.00536528582893771 29 6710616 SGTC_2210 7115885 190.385 µM 2.54899049221304 0.00527859672408347 no 79 0.00540176227915009 23 2927039 SGTC_3027 9089541 49.47 µM 2.53154053658857 0.00554526496303159 no 80 0.00567813450237068 31 9943819 SGTC_755 1995-0008 37.3 µM 2.51679791757842 0.00577981657391057 no 81 0.00592133660519909 16 689533 SGTC_766 1391-0721 126 µM 2.50851656626221 0.00591539684887164 no 82 0.00606196415136386 28 1020919 YIL115C NUP159 SGTC_987 1497-1013 404 µM 2.50514575940943 0.00597138564549217 no 83 0.00612004698430684 23 1676435 SGTC_626 0214-0009 33 µM 2.50497221697376 0.0059742808450128 no 84 0.00612305061972696 26 3437874 SGTC_2236 dapsone 200 µM 2.49424763393615 0.00615563104016134 no 85 0.00631122246064424 12 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2183 6420625 130.508 µM 2.49245559447695 0.00618640496329869 no 86 0.00634315963404624 51 2897619 SGTC_1238 0333-0287 48.8 µM 2.48311713461047 0.00634898589674658 no 87 0.00651191269103376 18 7226 SGTC_1714 st033236 13.627 µM 2.48190678618087 0.00637033232189954 no 88 0.00653407277211277 28 2916566 SGTC_1668 st014914 51.6 µM 2.48125301025311 0.00638188910468808 no 89 0.0065460703746071 28 2839556 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 2.47736807646815 0.00645094648383856 no 90 0.00661776641613122 25 3256 An antibiotic and ribosome inhibitor. SGTC_2903 5923464 63.88 µM 2.46230059353589 0.00672507615882137 no 91 0.0069024456757274 17 2876576 SGTC_518 1021-0119 62.6 µM 2.4550820460413 0.00686001650549853 no 92 0.00704262184046201 36 1097762 SGTC_799 1310-0557 151 µM 2.44865604007964 0.00698214759720502 no 93 0.00716951527738721 29 5354492 SGTC_424 splitomicin 100 mM 2.44477325501827 0.00705686958883677 no 94 0.00724716176308041 32 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2964 9083345 53.42 µM 2.43249127689857 0.00729789633919659 no 95 0.00749767635458041 49 17741579 SGTC_2871 9038510 12.99 µM 2.40780937778286 0.00780430638579139 no 96 0.00802427905237945 41 4945164 SGTC_194 1486-1323 56.904 µM 2.40169019742765 0.00793454194420105 no 97 0.00815976143251944 42 5178754 SGTC_227 fluconazole 33.516 µM 2.39762648301309 0.00802208319754348 no 98 0.00825084135415284 89 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2566 crystal violet carbinol 226 nM 2.38818448057068 0.00822877000215902 no 99 0.00846592006528522 66 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_415 dibenzyl ketone 100 µM 2.38536740661274 0.00829133545931304 no 100 0.00853103587282214 29 7593 SGTC_1741 st038134 10.228 µM 2.38326845666073 0.0083382230476062 no 101 0.00857983775117912 27 1272587 SGTC_136 0097-0015 404.482 µM 2.37165966387658 0.00860177495215866 no 102 0.00885419689713688 31 4861337 SGTC_851 0394-0702 453 µM 2.3615728079414 0.00883667903314012 no 103 0.00909879910021186 60 762646 SGTC_2313 7726885 200 µM 2.35724577272077 0.00893915873311966 no 104 0.00920552851627934 45 726423 SGTC_1062 mesoridazine 14.2 µM 2.34689903112926 0.00918843852088008 no 105 0.00946519195301079 35 4078 A neuroleptic. SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 2.34460778817432 0.00924445637951981 no 106 0.0095235520652357 32 66535 A nucleotide analog. SGTC_285 1486-1325 46 µM 2.33401363218654 0.00950737291082908 no 107 0.0097975040597237 41 22310230 SGTC_3159 9100096 49.47 µM 2.33207729928028 0.00955612745871884 no 108 0.00984831251570662 34 25236875 SGTC_3328 9140624 29.0385 µM 2.33166800974096 0.00956646081701596 no 109 0.00985908149038541 30 4904392 SGTC_2284 7945075 39.21 µM 2.31732812646212 0.00993472035938697 no 110 0.0102429321362198 29 1245402 SGTC_1966 st070145 16.1 µM 2.30236629419935 0.0103320865064055 no 111 0.0106572620533118 38 3748532 SGTC_869 0564-0080 44.1 µM 2.29620458366948 0.0104997195008932 no 112 0.0108320932966127 22 6843321 SGTC_10 0279-0212 42.575 µM 2.28029231068686 0.0109436283469724 no 113 0.0112951787745604 28 39851 YBR002C RER2 SGTC_1805 st050013 60.3 µM 2.27635689366776 0.0110559024832849 no 114 0.0114123287326071 24 4037144 SGTC_2026 5148700 152 µM 2.27176191249897 0.0111882600648817 no 115 0.0115504472293439 34 79838 SGTC_2790 5423970 71.43 µM 2.26732703311697 0.0113173102508085 no 116 0.0116851276218873 58 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1735 st034310 56.75 µM 2.26677664831211 0.0113334157380444 no 117 0.0117019366675463 42 871153 SGTC_948 3448-0295 75.3 µM 2.25874834803102 0.011570615741912 no 118 0.0119495215749494 38 678569 SGTC_1659 st012954 42.1 µM 2.25495209649185 0.0116842710668077 no 119 0.012068167885092 24 24207262 SGTC_325 2810-4341 181 µM 2.24313563157905 0.0120442669282069 no 120 0.0124440347864081 29 774970 SGTC_633 0437-0093 97.7 µM 2.23259836726284 0.0123733638319138 no 121 0.0127877209383144 41 2831118 SGTC_1635 st007035 42.4 µM 2.22801912454436 0.0125187920520565 no 122 0.0129396198593304 57 3716403 SGTC_607 4491-0986 66.8 µM 2.22663225470456 0.0125631274167008 no 123 0.0129859307194473 34 698981 YDR232W HEM1 SGTC_345 1362-0200 395 µM 2.22490233972619 0.0126186196881731 no 124 0.0130438974636324 40 1419823 SGTC_3323 9138564 53.9225 µM 2.21841215760038 0.0128287072181918 no 125 0.0132633714650641 40 43912313 YNL103W MET4 SGTC_797 k781-0471 270 µM 2.20824299534546 0.0131639671285919 no 126 0.0136136693516725 49 23738129 SGTC_2239 6685329 187.64 µM 2.20767940578985 0.0131827671241715 no 127 0.0136333147167143 29 805680 SGTC_2290 7904846 200 µM 2.20232054878544 0.013362687778411 no 128 0.0138213368382917 48 2962154 SGTC_910 3454-3003 490 µM 2.20052211763637 0.0134235425160519 no 129 0.0138849362373773 48 820824 SGTC_2043 5101342 149 µM 2.19581106785765 0.0135840891539492 no 130 0.0140527345722614 38 678451 SGTC_2208 7283366 200 µM 2.18952069344479 0.0138010389348477 no 131 0.0142795080866862 25 898663 SGTC_3350 9150499 3.57 µM 2.18772299502276 0.0138635865076895 no 132 0.0143448930072786 43 4910996 YPR165W RHO1 SGTC_64 000l-0018 272.079 µM 2.18657045350038 0.0139038155174539 no 133 0.0143869481248809 100 6811119 SGTC_2012 4023501 200 µM 2.18625368939857 0.0139148896620615 no 134 0.0143985251199819 60 3477460 SGTC_2176 5809774 33.9695 µM 2.18358502261821 0.0140084891550791 no 135 0.0144963775555153 16 2870539 SGTC_771 0250-0039 27.3 µM 2.1825067275718 0.0140464624005842 no 136 0.0145360776439332 38 3005115 SGTC_1049 3226-0134 66 µM 2.18212251981633 0.0140600140841973 no 137 0.0145502457922332 41 5702385 SGTC_1568 digitonin 820 nM 2.18174991345958 0.0140731673274138 no 138 0.0145639974747346 68 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1120 ficusin 1.78878 µM 2.17757856843385 0.0142211438508472 no 139 0.0147187132762825 39 6199 A DNA cross-linker. SGTC_1060 3448-7350 82 µM 2.16985025156378 0.0144988464230405 no 140 0.0150090960455558 53 570178 SGTC_327 1273-0057 3.96 µM 2.16595464433907 0.0146405885831641 no 141 0.0151573264928385 43 3108138 SGTC_370 0180-0345 38.7 µM 2.16552132662318 0.0146564283437176 no 142 0.0151738919924945 44 3989527 SGTC_1836 st055642 81 µM 2.16013581734862 0.014854527204432 no 143 0.0153810784924112 47 8571 SGTC_2135 5326629 150.42 µM 2.15760336472905 0.0149484732481646 no 144 0.0154793414392446 34 5020077 SGTC_11 0438-0307 1.3 µM 2.15655246776051 0.0149876079265791 no 145 0.0155202757416332 49 4011476 SGTC_731 3966-0296 387 µM 2.14194197921357 0.0155408821395396 no 146 0.0160990756214179 28 660956 SGTC_1303 1160-0052 261 µM 2.12757220008678 0.016102048571707 no 147 0.0166862845978919 30 3562476 SGTC_1162 k048-0130 20.1 µM 2.12173460115188 0.0163349288717512 no 148 0.016930015625193 50 6797406 SGTC_1081 sertraline 6 µM 2.11249116163803 0.0167095773639333 no 149 0.0173221716269283 44 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2479 5617353 43.85 µM 2.11020156132389 0.0168035057702627 no 150 0.0174204990576199 55 2731746 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 2.10224393080083 0.0171334793839443 no 151 0.0177659566754523 46 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1231 0242-0792 125 µM 2.10078624888752 0.0171945203516169 no 152 0.0178298670468661 40 3707635 SGTC_624 k048-0052 28 µM 2.09575349903071 0.017406698857377 no 153 0.0180520316651396 41 6835531 SGTC_677 0929-0063 136 µM 2.0927243340936 0.0175354818910118 no 154 0.0181868848549314 27 1539583 SGTC_291 SEC14.278 35.5 µM 2.09210819179071 0.0175617761028773 no 155 0.0182144192667029 45 1068044 SGTC_1698 5-fluorocytosine 1.055 µM 2.08844344763856 0.0177188674817083 no 156 0.0183789258606927 59 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1137 ixabepilone 100 µM 2.07997762178054 0.0180863498433545 no 157 0.0187637927480527 55 154225 A novel microtubule stabilizer. SGTC_485 niflumic acid 177 µM 2.06632917829947 0.0186924741112215 no 158 0.0193987040565423 43 4488 A COX2 inhibitor. SGTC_523 1934-0222 13.7 µM 2.06506190949703 0.0187496203733886 no 159 0.0194585714471577 55 1361595 SGTC_2463 5473429 200 µM 2.06457635434124 0.0187715553755682 no 160 0.0194815512424094 35 5399405 SGTC_1830 st055982 50.3 µM 2.0615284160836 0.0189097456331624 no 161 0.0196263276904478 41 455313 An antimicrobial agent. SGTC_2178 5812956 200 µM 2.0586419584113 0.0190414114166018 no 162 0.0197642750850507 40 5403383 SGTC_2641 levomentholum 100 µM 2.05598307421175 0.0191633854572601 no 163 0.0198920738482196 31 16666 SGTC_115 0527-0192 112.043 µM 2.05332737630079 0.0192858757189549 no 164 0.0200204187431537 79 4233931 SGTC_1263 0774-1208 64.8 µM 2.04695573046373 0.0195824747027957 no 165 0.0203312156850361 59 906585 SGTC_1271 0832-2808 169 µM 2.04459750157949 0.0196932276877986 no 166 0.0204472780141829 64 3663794 SGTC_3082 9117008 49.47 µM 2.0442060774515 0.0197116620805099 no 167 0.0204665965269521 33 41448529 SGTC_1192 1488-0095 21.4 µM 2.01242553825235 0.0212580601111491 no 168 0.0220875493288245 39 915875 SGTC_693 4161-2696 114 µM 2.00394154842416 0.0216878229286831 no 169 0.0225381610802891 45 805759 SGTC_1693 xanthone 101.9 µM 1.99899612030556 0.0219417072156659 no 170 0.0228043868211765 57 7020 An insecticide. SGTC_1164 k060-0068 93.7 µM 1.99502677863303 0.0221472931940928 no 171 0.0230199796545557 49 5963676 SGTC_406 estrone 100 µM 1.98500677305357 0.0226735067201402 no 172 0.0235718589736367 41 5870 A steroid. SGTC_455 paf C-16 10 µM 1.98314833013417 0.0227722548595144 no 173 0.0236754317273324 55 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.98000769991382 0.022939955556537 no 174 0.0238513317394553 46 551469 SGTC_1896 st058441 89 µM 1.95479826409624 0.0243241227313996 no 175 0.0253034430775369 59 688759 SGTC_2485 5633444 17.78 µM 1.95186659511754 0.0244895512414381 no 176 0.0254770226008366 52 5724239 SGTC_1226 3909-7979 35.4 µM 1.94848659807006 0.0246814490279442 no 177 0.0256783834437978 74 6615510 SGTC_2963 9082507 9 µM 1.94695198868286 0.0247689913080381 no 178 0.0257702454643618 64 16459611 SGTC_2399 5884133 200 µM 1.94224282717631 0.0250392543744274 no 179 0.0260538553479474 75 722445 SGTC_386 1509-0011 3.07 µM 1.92925452899689 0.0257975044379304 no 180 0.0268496358484783 51 3107280 SGTC_423 5-fluorouracil 457 µM 1.9287531110636 0.0258271580549883 no 181 0.0268807596726976 86 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2447 5741742 33.78 µM 1.92273595250542 0.0261852402631984 no 182 0.0272566096166553 67 1776504 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.92204598434112 0.0262265644279145 no 183 0.0272999859275583 80 279621 SGTC_2556 citropten 84.59 µM 1.92173884048898 0.0262449776816597 no 184 0.0273193136887581 48 2775 A potential DNA crosslinker. SGTC_2488 5268135 45.7 µM 1.91687480418742 0.0265380200941862 no 185 0.0276269193555849 78 1270356 YLR208W SEC13 SGTC_297 0986-0032 24 µM 1.90867531204183 0.0270381996308364 no 186 0.0281519949287106 57 2847425 SGTC_2246 7293507 91.5585 µM 1.90820533233007 0.027067105812582 no 187 0.0281823413557925 72 887656 SGTC_2094 5332512 191.667 µM 1.90706007385854 0.0271376531355573 no 188 0.028256404347908 50 755774 SGTC_1160 4092-0570 10.5 µM 1.90319469079882 0.027376892402976 no 189 0.0285075728402982 62 4994975 SGTC_438 sphingosine 6.67 µM 1.89996291498658 0.0275782636319128 no 190 0.0287189932651039 37 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1125 tnp00248 1.32998 µM 1.89622384404654 0.027812783409998 no 191 0.0289652257603138 81 24207736 SGTC_1416 3966-0321 25.3 µM 1.89304948752304 0.0280131854269423 no 192 0.0291756443282104 63 582530 YLR208W SEC13 SGTC_778 3456-2434 196 µM 1.89234560557515 0.0280577850882797 no 193 0.0292224741479147 54 5539063 SGTC_113 0099-0221 2.5 µM 1.89024539597778 0.0281912109904851 no 194 0.0293625739487552 55 89219 SGTC_2759 disulfiram 3.38 µM 1.88867427644838 0.0282913689092682 no 195 0.0294677437517237 83 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2943 9068529 45.32 µM 1.88839479415776 0.028309216727314 no 196 0.0294864848533397 86 3270634 SGTC_684 1140-0066 328 µM 1.88138022489101 0.0287602472350084 no 197 0.0299601074654453 59 6813534 SGTC_3254 9136651 49.47 µM 1.88120533127132 0.0287715686400643 no 198 0.0299719964001788 67 16454030 SGTC_2598 perillyl alcohol 100 µM 1.87937390336479 0.0288903453453073 no 199 0.0300967285350608 70 10819 An apoptosis inducer. SGTC_168 3970-0862 530.542 µM 1.87539362410393 0.0291498910085995 no 200 0.0303692958189497 129 3135186 SGTC_3329 9141233 27.5565 µM 1.87331355666136 0.0292862966846956 no 201 0.0305125494675549 59 4909101 YNL103W MET4 SGTC_1419 3993-2473 62.6 µM 1.87165140065878 0.0293956774473178 no 202 0.0306274236282302 49 704026 SGTC_957 1187-1561 14.1 µM 1.87059055108136 0.029465665478425 no 203 0.0307009276472392 63 1538454 SGTC_1785 bathophenanthroline 24 µM 1.86929691431842 0.0295511984582215 no 204 0.030790758598622 94 72812 An iron chelator. SGTC_547 1120-0019 610 nM 1.86469204975516 0.0298573380788221 no 205 0.0311122908977356 55 3676939 SGTC_1275 0867-0008 21.1 µM 1.86409764068724 0.029897046487261 no 206 0.0311539969052149 58 3422836 SGTC_158 k038-0087 26.446 µM 1.85706111890671 0.0303704455431064 no 207 0.0316512295391819 86 X158 SGTC_377 3970-0964 33.1 µM 1.85704786320886 0.030371343179795 no 208 0.0316521723998716 64 16481235 SGTC_2150 5556613 200 µM 1.85624024824435 0.0304260739634318 no 209 0.0317096608105654 64 743190 SGTC_2261 9010538 184.68 µM 1.84918493292388 0.0309076849738333 no 210 0.0322155568023184 57 6457250 SGTC_1934 st074720 32.6 µM 1.84858626893407 0.0309488398668074 no 211 0.0322587884585085 72 17250992 SGTC_662 k832-1615 104 µM 1.84249772390861 0.0313699758631573 no 212 0.0327011895745646 57 5878478 SGTC_1932 st074806 40.9 µM 1.84161203549943 0.0314316306307925 no 213 0.0327659596476256 71 17251235 SGTC_48 0382-0018 55 µM 1.84116260296004 0.0314629549399041 no 214 0.0327988669181076 38 762596 SGTC_171 k064-0041 9.68 µM 1.83517425531972 0.0318827958881999 no 215 0.0332399372009664 68 53325 SGTC_1667 st014849 34.6 µM 1.83511574689891 0.0318869206085446 no 216 0.0332442706058007 56 5348460 SGTC_2362 9071156 126 µM 1.82070121590078 0.03291662810521 no 217 0.034326143631858 60 653133 SGTC_708 3448-5400 146 µM 1.81802624001926 0.0331106989718114 no 218 0.0345300611544884 105 3462195 SGTC_2003 4023581 200 µM 1.81763576247614 0.0331391070070727 no 219 0.03455991092544 64 16641307 SGTC_1071 trifluoperazine 6.31 µM 1.81055641520959 0.0336576353283523 no 220 0.0351047720415878 64 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_271 rotenone 740 µM 1.79908297286239 0.0345121769415379 no 221 0.0360027783263613 50 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1149 3909-7961 23.3 µM 1.79285569268496 0.0349833971267625 no 222 0.0364980007926412 63 735261 SGTC_1768 st044301 37.178 µM 1.78683439861276 0.03544403909372 no 223 0.0369821289353084 76 3931349 SGTC_2423 st077119 87.2 µM 1.7796902523009 0.0359970206913262 no 224 0.0375633333019925 58 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2459 5811157 9.22 µM 1.76440107702475 0.0372042113762925 no 225 0.0388322384902748 67 2870684 YBR192W RIM2 SGTC_2561 acetosyringone 100 µM 1.76263945742169 0.0373454048599559 no 226 0.038980658887228 70 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1402 3909-7673 35.9 µM 1.76225772869672 0.0373760579757182 no 227 0.0390128812004662 50 5328014 SGTC_3013 9080133 71.4286 µM 1.76181581878446 0.0374115693515746 no 228 0.0390502105822077 64 17050193 SGTC_712 r015-0009 80.6 µM 1.76007633885243 0.0375516197939932 no 229 0.039197431992093 49 6813872 YLR060W FRS1 SGTC_123 0083-0120 66.675 µM 1.7598678376239 0.0375684355115218 no 230 0.0392151088359844 85 16001701 SGTC_407 eburnamonine 100 µM 1.75833619466587 0.0376921517652181 no 231 0.0393451613063143 61 3195 SGTC_16 erodoxin 22.806 µM 1.75739248856409 0.0377685437105318 no 232 0.039425466380346 107 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2137 5261020 140 µM 1.74962350485533 0.0384022477683491 no 233 0.0400916505580112 67 763655 SGTC_95 0471-0001 561.058 µM 1.74911243572551 0.0384442369255861 no 234 0.0401357930213169 68 4015405 SGTC_1724 st037281 8.293 µM 1.73142671494312 0.0399204925825441 no 235 0.041687842628407 80 574124 YDL195W SEC31 SGTC_751 0833-0568 350 µM 1.72228789171624 0.0407011921481632 no 236 0.0425086900088085 65 6954252 SGTC_2686 alizarin 95.37 µM 1.72092983648514 0.0408182567165604 no 237 0.0426317783176036 66 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1837 st055472 66.5 µM 1.71876424881071 0.0410054957063881 no 238 0.0428286539006502 58 676091 SGTC_1708 st033234 31.827 µM 1.71737506735149 0.0411259721245802 no 239 0.0429553320893242 71 674664 SGTC_839 0122-0028 230 µM 1.70515685366694 0.0421980014284728 no 240 0.0440825872669731 128 759448 SGTC_2920 7982904 15.77 µM 1.70288459705714 0.0423998419116077 no 241 0.0442948335426195 80 6456808 SGTC_342 k048-0088 23.3 µM 1.69293712869011 0.0432926683302115 no 242 0.0452337175493956 87 6820570 SGTC_654 1124-0271 80.9 µM 1.69230614707546 0.043349809742998 no 243 0.0452938081971779 82 5403748 SGTC_726 3448-4391 34.2 µM 1.69120471528918 0.0434497008257006 no 244 0.0453988553766716 70 1356692 SGTC_1748 st037455 53.6035 µM 1.69030940511561 0.0435310351579916 no 245 0.0454843883565758 89 580690 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.68624760842504 0.0439015731712442 no 246 0.0458740587629067 94 688788 SGTC_1385 3091-4834 14.1 µM 1.68259395018511 0.0442370481426737 no 247 0.0462268618272968 64 4072814 SGTC_838 0109-0203 71.4 µM 1.67605154224984 0.0448429256545414 no 248 0.0468640486083376 66 759422 SGTC_2766 oltipraz 83.91 µM 1.67321188404825 0.0451079708742849 no 249 0.047142795830688 95 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_968 1309-0633 340 µM 1.67304059328835 0.0451239988723005 no 250 0.04715965253107 78 3761976 SGTC_1131 3454-3128 32.3 µM 1.67027046780414 0.0453838416231047 no 251 0.0474329316901465 84 710982 SGTC_2123 5259487 200 µM 1.66967561463163 0.0454397965839614 no 252 0.0474917804711675 73 2173474 SGTC_2916 7875993 68.79 µM 1.66834505957902 0.0455651563109946 no 253 0.0476236239315673 80 1299250 SGTC_148 3253-0744 288.01 µM 1.6638555466329 0.0459901940392045 no 254 0.0480706501950223 73 6893655 SGTC_1146 3579-1023 7 µM 1.66265934457518 0.0461039784272649 no 255 0.0481903223272214 89 X1146 SGTC_2648 atorvastatin 78.68 µM 1.65823948010182 0.0465263645993828 no 256 0.0486345694915697 71 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2710 st078562 53.7235 µM 1.65341643495196 0.0469908186864947 no 257 0.0491230701522299 85 17250908 SGTC_1678 st019265 80.2 µM 1.65320491705682 0.0470112724282832 no 258 0.049144583057063 68 5367020 SGTC_3125 9127534 49.47 µM 1.65012026206658 0.0473103699440969 no 259 0.0494591706626497 54 1639235 SGTC_2805 7950783 58.44 µM 1.64772495800034 0.0475436762141886 no 260 0.0497045620539392 82 1178958 YDL195W SEC31 SGTC_3253 9135987 49.47 µM 1.64000588942757 0.0483018015138959 no 261 0.0505019712057195 87 4182430 SGTC_3007 9078383 71.4286 µM 1.63809416342106 0.0484910472489502 no 262 0.0507010261742509 89 6496995 SGTC_153 4077-0274 519.67 µM 1.63202947339308 0.0490953300644952 no 263 0.0513366387169372 88 3121976 SGTC_736 0958-0254 92.6 µM 1.62655788360809 0.0496456640786061 no 264 0.0519155151704257 83 6812352 SGTC_3029 9088683 49.47 µM 1.62286560753255 0.0500198078982997 no 265 0.0523090685215297 68 25236615 SGTC_1883 5-benzylidenerhodanine 20 µM 1.62094438532956 0.0502153756347083 no 266 0.0525147832992906 83 1273210 SGTC_1801 st050089 28.441 µM 1.61718136345278 0.0506001921310674 no 267 0.0529195689753164 97 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_886 0866-0150 153 µM 1.60862290174441 0.0514841499335671 no 268 0.0538494116973044 81 271463 SGTC_3016 9080866 49.47 µM 1.60820107482915 0.0515280337471849 no 269 0.0538955739301555 73 17066299 SGTC_441 propafenone 146 µM 1.60800814485246 0.0515481146936312 no 270 0.0539166974807328 82 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2122 5258151 111.688 µM 1.60705378347039 0.0516475400962387 no 271 0.0540212851890545 90 2173356 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.60238064027933 0.0521365912025342 no 272 0.0545357316139556 109 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_608 k048-0125 159 µM 1.59312959197872 0.0531155701370076 no 273 0.0555655610302971 82 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1050 3232-1156 69.3 µM 1.58997647922284 0.053452554777105 no 274 0.0559200534595666 105 700529 SGTC_2922 7999257 32.47 µM 1.58626787910477 0.0538510719954347 no 275 0.0563392777469706 86 2988377 SGTC_966 1300-0360 30.2 µM 1.57790797863617 0.0547580353058062 no 276 0.0572933758852856 112 70588 SGTC_1079 idarubicin 2.36 µM 1.57305414657162 0.0552901414327799 no 277 0.0578531405315078 91 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2811 7967822 32.47 µM 1.56686140607156 0.0559749458079328 no 278 0.0585735452013507 85 2232244 SGTC_3041 9091929 49.47 µM 1.56648046036793 0.0560172889341484 no 279 0.0586180897340652 88 25236887 SGTC_1637 st007924 17.4 µM 1.56590772980071 0.0560809969960472 no 280 0.0586851099903807 71 683336 SGTC_2736 butenafine 14.65 µM 1.56575075699975 0.0560984679418549 no 281 0.0587034892605186 87 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2913 7966556 36.57 µM 1.56390221505679 0.0563045322066529 no 282 0.0589202671277109 85 2976516 SGTC_2915 7971052 15.16 µM 1.56336486061086 0.0563645450325308 no 283 0.0589834001830584 63 5741558 SGTC_1909 st060837 51.5 µM 1.56095913560572 0.0566338396164659 no 284 0.05926669648536 95 678937 SGTC_561 1550-0330 72.9 µM 1.56027442628941 0.0567106703520341 no 285 0.0593475220669126 87 6812934 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.55552337648653 0.0572460458583613 no 286 0.059910735805998 83 756377 SGTC_1849 st056239 19.2 µM 1.55501239808377 0.0573038619449148 no 287 0.0599715583011306 78 5393181 SGTC_3153 9100258 49.47 µM 1.55379905444685 0.0574413332126431 no 288 0.0601161780876552 80 25236848 SGTC_1202 1988-0068 29.6 µM 1.55352832141799 0.0574720425140203 no 289 0.0601484842903429 79 2850480 SGTC_2743 auranofin 4.32 µM 1.55328546849223 0.0574996003571403 no 290 0.0601774751615934 65 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2029 5175081 200 µM 1.54677642489129 0.0582420968751849 no 291 0.0609585834447815 83 1380876 SGTC_579 4491-1009 110 µM 1.54656391724345 0.0582664643193007 no 292 0.0609842180995493 113 1271041 SGTC_1041 0206-0046 107 µM 1.544800627422 0.0584689630939708 no 293 0.0611972477506795 89 50494 SGTC_2128 5255449 168.493 µM 1.54238291195081 0.0587475149259302 no 294 0.0614902857763229 89 736008 SGTC_2516 gossypol 71.55 µM 1.53840632659678 0.0592079327160081 no 295 0.0619746481626102 98 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1583 clindamycin 39.6 µM 1.53765252075739 0.0592955282132229 no 296 0.062066799212054 95 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1407 3909-7909 12.3 µM 1.53500820415146 0.0596036128817856 no 297 0.0623909064073275 76 4411780 SGTC_575 k072-0246 11.9 µM 1.53440234848126 0.0596743763830903 no 298 0.0624653501073031 92 6796779 SGTC_653 0203-0016 55.2 µM 1.53424674585003 0.059692561277681 no 299 0.0624844807443138 89 295302 SGTC_1797 st048695 56.8 µM 1.52849113932153 0.060368260396152 no 300 0.0631953209164138 99 592262 YIL048W NEO1 SGTC_3284 9108171 64.8615 µM 1.5267771263149 0.0605706353014495 no 301 0.0634082206447262 90 8687505 SGTC_119 0121-0043 24.815 µM 1.52313800320107 0.0610020689152378 no 302 0.0638620913829178 134 1092378 SGTC_2865 9030313 51.95 µM 1.52179544428261 0.061161840261933 no 303 0.064030171678626 73 42562754 SGTC_2630 antimycin a 100 µM 1.52083766262082 0.061276020885118 no 304 0.064150290247712 98 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_840 0245-0196 390 µM 1.51860343567699 0.0615430185487097 no 305 0.0644311729144957 100 3827528 SGTC_2539 epi(13)torulosol 80 µM 1.51639526542866 0.0618077942192576 no 306 0.0647097177683873 95 6708597 SGTC_2810 7959871 45.46 µM 1.51418306900515 0.0620739434571526 no 307 0.0649897073121297 105 2974535 SGTC_2376 9072922 81.32 µM 1.51352399136807 0.0621534096985334 no 308 0.065073305895344 93 17087968 SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.51269832079381 0.0622530743282028 no 309 0.0651781531623821 97 5282309 SGTC_2083 5306046 65.942 µM 1.50649043622675 0.0630064092171449 no 310 0.0659706602063384 86 539837 SGTC_854 0422-0053 192 µM 1.49801945530336 0.0640458065000088 no 311 0.0670640978957485 94 3596728 SGTC_1334 1486-0610 236 µM 1.49523170501007 0.0643907663268267 no 312 0.0674269908894987 100 3742339 SGTC_524 r073-0010 27.8 µM 1.49449425640733 0.0644822602102023 no 313 0.067523241009874 111 2772106 SGTC_1627 st003713 25.6 µM 1.49384019934998 0.0645634923451929 no 314 0.0676086958651157 93 16195070 YER133W GLC7 SGTC_303 1348-1668 34.2 µM 1.49237230831521 0.0647460898581682 no 315 0.0678007851739338 95 5380509 SGTC_541 4513-1321 94 µM 1.49123165951603 0.0648882569341003 no 316 0.0679503421536154 125 747515 SGTC_2327 6189656 200 µM 1.49107612069659 0.0649076615922399 no 317 0.0679707554576979 91 5349088 SGTC_1493 4348-0038 111 µM 1.49101250291739 0.064915599695083 no 318 0.0679791061786405 137 800424 SGTC_2406 ethylparaben 405.7 µM 1.49007999043102 0.0650320432973639 no 319 0.0681016023770327 88 8434 A possible steroid mimic. SGTC_1886 st057356 49.9 µM 1.48363796197532 0.0658408981293209 no 320 0.068952496324641 92 24207747 SGTC_2418 pentamidine 31.67 µM 1.48019487366441 0.0662763947669364 no 321 0.0694106240562992 111 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2771 fluoxetine 41.05 µM 1.47716973810452 0.0666608650533949 no 322 0.0698150717515623 84 3386 A selective serotonin reuptake inhibitor. SGTC_671 0560-0003 407 µM 1.4759484150471 0.0668165735689011 no 323 0.0699788704475263 73 3238678 SGTC_3356 9151811 4.48 µM 1.47377599386841 0.0670942344327612 no 324 0.0702709569535563 100 1859254 YPR165W RHO1 SGTC_2760 etidronate 98.04 µM 1.46856854024257 0.0677634405837337 no 325 0.0709749265233815 91 3305 A chelator and antioxidant. SGTC_317 4495-0002 170 µM 1.46697032301944 0.0679698569829091 no 326 0.0711920643046756 88 15991618 SGTC_1565 sinapyl alcohol 95.1 µM 1.46277577860487 0.0685139090340355 no 327 0.071764371436088 102 5280507 A phenol propionate derived from cinnamic acid. SGTC_233 rapamycin 362 pM 1.46216379755329 0.0685935658737635 no 328 0.0718481648041775 90 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1972 st070201 17.4 µM 1.45420416842251 0.069636126612127 no 329 0.0729448548377048 95 2829099 SGTC_269 exalamide 29 µM 1.45305663702843 0.0697874323888271 no 330 0.0731040147053921 113 3316 A derivative of salicylamide. SGTC_914 3820-6779 408 µM 1.45093004208183 0.0700684997174816 no 331 0.0733996707329415 86 2893481 SGTC_675 1309-0189 238 µM 1.4477411979991 0.0704915930732799 no 332 0.0738447217127399 94 4246530 SGTC_3055 9094636 49.47 µM 1.44692019738856 0.0706008400652625 no 333 0.0739596378103857 127 25236176 SGTC_1539 benzyladenosine 56 µM 1.44681392445349 0.0706149908512052 no 334 0.0739745228992617 104 92208 A nucleotide analog. SGTC_1789 tunicamycin 25 nM 1.44532729476331 0.0708131718186083 no 335 0.0741829873126024 120 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1378 2093-0007 380 nM 1.44255111629376 0.071184404859888 no 336 0.0745734811587787 119 3618014 SGTC_258 haloperidol 50.781 µM 1.44054979397893 0.0714529490165519 no 337 0.0748559564798826 131 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_514 4466-0038 2.65 nM 1.4388981072751 0.0716751629335178 no 338 0.07508969693912 137 5722064 SGTC_116 0155-0182 31.788 µM 1.43321427460415 0.0724439044426903 no 339 0.075898305751192 104 771486 SGTC_1044 1222-0021 1.78 µM 1.43147918536988 0.0726798302674829 no 340 0.0761464641244446 132 4306703 SGTC_2511 berberine 10.47 µM 1.43091013082888 0.0727573344919121 no 341 0.0762279865946194 117 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3179 9107801 49.47 µM 1.43074680997049 0.0727795901882694 no 342 0.0762513961229809 79 4818259 SGTC_949 1165-0505 146 µM 1.42700316505495 0.0732911661282519 no 343 0.0767894911648369 89 6244267 SGTC_2925 9010536 32.5 µM 1.42678051214922 0.0733216785041952 no 344 0.076821585045927 80 2994177 SGTC_1677 st019204 53.9 µM 1.42544627270696 0.0735047264236854 no 345 0.0770141201588261 94 3945625 SGTC_3272 9137413 49.47 µM 1.42511245556839 0.0735505783067253 no 346 0.0770623483723389 104 17614870 SGTC_2512 diallyl trisulfide 49.23 µM 1.4176945971695 0.074575119537213 no 347 0.0781399740817599 123 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1363 1636-0063 10.4 µM 1.41430877529316 0.0750463684460624 no 348 0.0786356307641929 126 6072185 SGTC_3108 9121785 49.47 µM 1.41423416067575 0.0750567790502916 no 349 0.0786465805074195 119 17140271 SGTC_2283 7944793 200 µM 1.41407315326937 0.0750792473605349 no 350 0.0786702123851387 109 2970533 SGTC_2331 7980721 200 µM 1.41398599667396 0.0750914120550363 no 351 0.0786830070476868 128 2981221 SGTC_1911 st060208 74.3 µM 1.40665721892962 0.076119696693607 no 352 0.0797645286238145 118 688783 SGTC_1003 4049-0218 100 µM 1.40580561752383 0.0762398747885128 no 353 0.0798909267528051 129 295161 SGTC_237 nikkomycin 200 µM 1.40554445256667 0.0762767593368967 no 354 0.0799297202465254 115 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1157 4092-0394 27.6 µM 1.40469035170057 0.0763974795543736 no 355 0.0800566880243725 98 3659885 SGTC_538 2922-0838 53.3 µM 1.40362828365084 0.0765477969469354 no 356 0.0802147841272937 130 777039 SGTC_3233 9132340 49.47 µM 1.40303455670222 0.0766319267222221 no 357 0.0803032672185777 142 17682950 SGTC_3073 9114972 49.47 µM 1.40092358364912 0.076931616409656 no 358 0.080618462778784 88 41905075 SGTC_1267 0828-0272 9.49 µM 1.39877865494396 0.0772370383599074 no 359 0.0809396845195224 112 745334 SGTC_1547 harmine 94.2 µM 1.39356422802804 0.0779833751652677 no 360 0.0817246185410004 130 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_279 1273-0055 2.93 µM 1.39200063501262 0.0782082340268554 no 361 0.0819611028310047 132 2847562 SGTC_343 4130-2827 29.8 µM 1.39041067084667 0.0784373892154393 no 362 0.0822021039890824 103 1118244 SGTC_260 nsc-65238 3.989 µM 1.38426958853594 0.0793272607163362 no 363 0.0831379611695306 113 3246252 SGTC_3264 9137442 49.47 µM 1.38194036029742 0.0796667685018814 no 364 0.0834950070362159 107 17015726 SGTC_1200 1643-0193 18.4 µM 1.37897103036786 0.0801011698619012 no 365 0.0839518430203077 121 5403974 SGTC_2708 st078559 56 µM 1.37389949878037 0.080847252525876 no 366 0.0847364426375528 77 17250902 SGTC_3117 9124945 49.47 µM 1.37072311044003 0.0813172018766029 no 367 0.0852306438604357 88 17592065 SGTC_713 1488-1073 324 µM 1.36367072607004 0.0823679708183361 no 368 0.0863356107050343 111 3312542 SGTC_1922 5578187 25 µM 1.36195797388703 0.082624698385378 no 369 0.0866055742455547 120 1350412 SGTC_3137 9097352 49.47 µM 1.36025944067776 0.0828798889625148 no 370 0.08687391924186 126 44120435 SGTC_1745 st081495 74 µM 1.35615666848579 0.0834987419354427 no 371 0.087524662815221 132 13842402 YBL026W LSM2 SGTC_577 r071-0003 38.6 µM 1.3558106882001 0.0835510871739911 no 372 0.0875797048630242 123 4568517 YMR134W ERG29 SGTC_1653 st012112 65 µM 1.3549741310173 0.0836777563475426 no 373 0.0877128995775901 90 720429 SGTC_2053 5265679 138 µM 1.35467279426862 0.0837234192513287 no 374 0.087760914726733 132 764595 SGTC_3190 9110366 49.47 µM 1.35337835540512 0.0839197842851929 no 375 0.0879673942954177 104 17123768 SGTC_3050 9093513 49.47 µM 1.35309473059334 0.083962856031075 no 376 0.0880126844277021 138 25236664 SGTC_2682 pyrogallin 40.03 µM 1.35180480020706 0.0841589564986453 no 377 0.0882188840772665 111 822798 An ATP competetive kinase inhibitor. SGTC_2071 5230951 39.92 µM 1.34971586287764 0.0844772541460871 no 378 0.0885535710351634 135 1799272 SGTC_2504 purpurogallin 52.29 µM 1.34920453387428 0.0845553042989632 no 379 0.0886356394549876 108 5281571 An antioxidant. SGTC_2468 5987765 72.9 µM 1.34917411003619 0.0845599499512479 no 380 0.088640524272863 110 26772094 SGTC_2888 9058547 12.99 µM 1.33747091216779 0.0863612396393658 no 381 0.0905344854564253 90 16476514 SGTC_2935 9038016 29.96 µM 1.33583471884901 0.0866153424698617 no 382 0.0908016511004461 128 6463195 SGTC_3051 9093778 49.47 µM 1.33353864971001 0.0869728666058719 no 383 0.0911775503806223 144 17217378 SGTC_1115 galangin 695.678 nM 1.32318614193694 0.0885985687378667 no 384 0.0928867416912313 127 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1902 st060212 70.5 µM 1.32088263866003 0.0889633575825759 no 385 0.0932702497270598 117 688944 SGTC_138 0850-0259 40.9225 µM 1.32026085849914 0.0890620156924072 no 386 0.0933739695442755 158 6813004 SGTC_2665 lovastatin 100 µM 1.31848898436947 0.0893436063200565 no 387 0.0936700050999888 119 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_3084 9116877 49.47 µM 1.31714626982222 0.0895574345715281 no 388 0.0938948000151416 95 27241325 SGTC_3155 9099265 49.47 µM 1.31553877269675 0.089813929895841 no 389 0.0941644477433991 111 25236499 SGTC_1474 0330-0125 5.35 µM 1.31348751800344 0.0901420244744049 no 390 0.0945093620916249 108 X1474 SGTC_2024 5144227 134 µM 1.30786020734774 0.0910466736265142 no 391 0.095460364269644 113 3475211 SGTC_2452 5863136 48.41 µM 1.3066388172602 0.0912439112489801 no 392 0.095667703401796 109 2184096 SGTC_2450 5739737 12.93 µM 1.30482577136087 0.0915372770404105 no 393 0.0959760907689638 110 2262825 SGTC_1899 st063254 59.6 µM 1.30446419262357 0.0915958669755488 no 394 0.0960376803077474 122 3093813 SGTC_1174 0739-0097 51.1 µM 1.30349414195162 0.0917531905018898 no 395 0.0962030575149764 135 728447 SGTC_420 mitomycin C 81.9 mM 1.30207522174944 0.0919836724392672 no 396 0.0964453362841654 134 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3053 9095903 49.47 µM 1.29036941916058 0.093901480453834 no 397 0.0984612123334856 142 17174018 SGTC_2885 9057732 51.95 µM 1.2891602531334 0.0941012522134382 no 398 0.0986711899649399 142 6471414 SGTC_3269 9137823 49.47 µM 1.28907831463082 0.0941148009777013 no 399 0.0986854308377989 92 17682936 SGTC_938 3126-1755 342 µM 1.28898497265975 0.0941302370914224 no 400 0.0987016554609388 115 1777771 SGTC_2241 6772625 37.8075 µM 1.28659322367005 0.0945264018478386 no 401 0.0991180534116147 134 2285411 SGTC_2575 plumbagin 510 nM 1.28445508348116 0.0948815987571306 no 402 0.0994913850277338 133 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1998 st075797 76.8 µM 1.28250970462153 0.0952056268693185 no 403 0.0998319514108945 132 24208315 SGTC_1169 aniline yellow 25.8 µM 1.27784186955445 0.0959864373491877 no 404 0.100652594004389 129 6051 A DNA damaging agent. SGTC_1713 st033146 12.748 µM 1.27598325240907 0.0962986442109466 no 405 0.100980719693445 128 674619 SGTC_1285 0929-0069 65.5 µM 1.27546889854231 0.096385176072534 no 406 0.101071662831001 105 1206237 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.27458645113575 0.0965337669060683 no 407 0.101227827792235 133 676296 Flavone; oxidizing agent. SGTC_1390 3413-2614 145 µM 1.27052367454846 0.0972200485580548 no 408 0.101949077639568 157 3421432 SGTC_3180 9109287 49.47 µM 1.26940358505137 0.0974098814296723 no 409 0.102148579100155 136 18891271 SGTC_1944 st076371 56.9 µM 1.2668967665957 0.0978357222092958 no 410 0.102596102520535 123 24208455 SGTC_2397 5161689 200 µM 1.25649135330147 0.0996179111055899 no 411 0.104468939469473 115 2259942 SGTC_3005 9076496 71.4286 µM 1.25605281482221 0.0996935394287187 no 412 0.104548411032256 122 21368410 SGTC_1102 cgs 12066b 26.1 µM 1.25385943708976 0.100072428891982 no 413 0.10494655040279 123 6438352 A 5-HT1B full agonist. SGTC_931 2812-0076 566 µM 1.24869938635798 0.100967932738435 no 414 0.105887522701921 136 3450959 SGTC_3093 9117344 49.47 µM 1.24575539936846 0.10148145858691 no 415 0.106427104096218 124 24824913 SGTC_688 0527-0193 473 µM 1.24163895617122 0.102202684192279 no 416 0.107184900903697 136 4007154 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.24147386660302 0.102231686444672 no 417 0.107215373215766 118 2724278 An inhibitor of dopamine biosynthesis. SGTC_2984 9022109 38.96 µM 1.24023373357983 0.102449739288385 no 418 0.107444477285747 152 6459207 SGTC_2226 7298446 200 µM 1.23981149358371 0.102524058950712 no 419 0.107522563013215 111 3283010 SGTC_363 0455-0021 3.06 µM 1.23953921106215 0.102572004954246 no 420 0.107572938475059 150 4597466 SGTC_584 0986-0246 15.4 µM 1.23915568894565 0.102639566691967 no 421 0.107643923412686 182 53315 YDR232W HEM1 SGTC_2004 4023728 41.89 µM 1.23734455807019 0.102959054853418 no 422 0.10797959611257 175 360084 YDR527W RBA50 SGTC_1974 st069448 26.9 µM 1.23407249738434 0.103538085284175 no 423 0.108587945376143 115 6323587 YNR016C ACC1 SGTC_1233 0325-0408 14.2 µM 1.23281474232382 0.103761287785535 no 424 0.108822444917563 133 12874 SGTC_191 3914-0123 66.505 µM 1.23248442687568 0.103819963733895 no 425 0.10888409022258 144 3144412 SGTC_1821 st053465 65.6 µM 1.23199292565798 0.103907316638726 no 426 0.108975863376278 114 675086 SGTC_1999 st074831 12.5 µM 1.23159665050828 0.103977784129971 no 427 0.109049896385376 150 17112523 SGTC_765 1319-0117 244 µM 1.23141963412117 0.104009273203063 no 428 0.109082978659899 129 3487746 YGL099W LSG1 SGTC_350 k064-0020 19.8 µM 1.22815244857488 0.104591708099447 no 429 0.109694872647733 140 2790705 SGTC_3231 9132313 49.47 µM 1.22767074950689 0.104677779120349 no 430 0.10978529555217 136 4905967 SGTC_883 0850-0245 24.6 µM 1.2275448538923 0.10470028287192 no 431 0.109808937063409 152 6823229 YPR165W RHO1 SGTC_1511 0906-3109 28.5 µM 1.22739808616948 0.104726521921053 no 432 0.109836502689984 140 2882180 SGTC_2840 9008771 71.43 µM 1.22674224692166 0.104843830671928 no 433 0.109959741816853 88 2992978 SGTC_1446 4239-0190 62 µM 1.22672749138141 0.104846471062011 no 434 0.109962515679676 137 1340085 SGTC_1019 4262-0212 3.4 µM 1.22623020041648 0.104935485599723 no 435 0.110056029720062 155 4677213 SGTC_1329 1447-1697 50.6 µM 1.22603497600408 0.104970445506418 no 436 0.110092756663354 124 2840515 SGTC_46 0329-0187a 2.197 µM 1.22579036216078 0.10501426174922 no 437 0.110138787491506 136 46494817 SGTC_2832 7992762 51.95 µM 1.22225214706077 0.105649522691611 no 438 0.110806144655433 129 2985177 SGTC_597 k018-0003 82.8 µM 1.21734804236612 0.106534607000698 no 439 0.111735911310757 140 6786234 SGTC_1296 1068-0102 11.9 µM 1.21703431165623 0.10659141020419 no 440 0.11179558070885 124 767053 SGTC_1318 1280-3875 124 µM 1.2162241658371 0.106738194048398 no 441 0.111949770211516 165 373245 SGTC_729 4092-0585 94.1 µM 1.21617771772837 0.106746614029008 no 442 0.111958614968477 127 2169061 SGTC_3299 9121982 43.1275 µM 1.21367472141264 0.107201059161672 no 443 0.112435980519174 129 17594604 YPL160W CDC60 SGTC_1490 4089-0339 670 nM 1.21331921936031 0.107265717244085 no 444 0.112503898787306 148 742542 SGTC_2939 9044578 71.43 µM 1.21307640436538 0.107309896162373 no 445 0.112550305161202 131 2653634 SGTC_529 4076-0302 30.3 µM 1.21162554474199 0.107574145858275 no 446 0.112827875831558 133 5816522 SGTC_2432 5630864 12.22 µM 1.21158102902673 0.107582261055218 no 447 0.11283640005974 138 5714970 SGTC_2513 baicalein 25.65 µM 1.21049921318283 0.107779611288515 no 448 0.113043696251226 151 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_975 1335-0046 28.5 µM 1.20598401823834 0.108606111102198 no 449 0.113911826360099 138 16486740 SGTC_329 k048-0121 21.3 µM 1.20584658134732 0.108631340020306 no 450 0.113938325451599 142 6832902 SGTC_3300 9124615 50.48 µM 1.20407078831876 0.108957696694961 no 451 0.114281109683902 132 24824903 SGTC_2866 9034245 58.44 µM 1.20327493841796 0.109104187118505 no 452 0.114434971961176 111 6462273 SGTC_2011 4012611 177 µM 1.20307378614027 0.109141235194636 no 453 0.114473884223049 124 2049887 SGTC_13 0199-0087 65 µM 1.20182619552136 0.109371217424115 no 454 0.11471543699603 152 4589825 SGTC_1641 st009299 47.1 µM 1.19952279739297 0.10979674261611 no 455 0.115162362847241 148 4046054 SGTC_1333 1482-0047 286 µM 1.19462728128824 0.110705074257181 no 456 0.116116342705945 142 3811116 SGTC_2980 9014342 25.29 µM 1.19088456509344 0.111403134446379 no 457 0.116849452332501 179 2996599 SGTC_816 0325-0417 81.3 µM 1.18947192189587 0.111667426103289 no 458 0.11712700680535 143 68101 SGTC_2 0422-0095 29 µM 1.18889045481537 0.111776343092511 no 459 0.117241388365937 134 6790840 SGTC_1636 st007707 68.9 µM 1.18640828719787 0.11224214259644 no 460 0.117730550283621 153 403051 SGTC_1523 st012844 44.7 µM 1.1862028114089 0.112280763925939 no 461 0.11777110812961 114 4274103 SGTC_1021 4476-0760 85.3 µM 1.18224491417488 0.113026546175222 no 462 0.118554267969181 123 746768 SGTC_2892 9047358 58.44 µM 1.18176674373329 0.113116886104739 no 463 0.118649133442912 133 6466771 SGTC_1588 farnesol 29.9 µM 1.18149875605294 0.113167539086352 no 464 0.118702323660567 151 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2000 st075254 36.4 µM 1.18023791288212 0.113406071206376 no 465 0.118952801998278 136 17234175 SGTC_2368 9071271 200 µM 1.17811618877942 0.113808277747065 no 466 0.119375144489131 136 27209959 SGTC_475 α-linolenic acid 10 µM 1.17282210155444 0.114816286431664 no 467 0.120433576562317 149 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2056 5235370 200 µM 1.17228514210794 0.114918878644077 no 468 0.120541297400204 136 5511916 SGTC_1074 carmofur 3.8 µM 1.16644095971487 0.11603969451572 no 469 0.121718103084922 169 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3303 9125618 40.5795 µM 1.16603186720821 0.116118441176624 no 470 0.121800780716719 144 22695467 SGTC_2820 7989630 71.43 µM 1.16079645599572 0.11712956107345 no 471 0.122862342290322 102 2984098 SGTC_834 0312-0008 75.7 µM 1.15949733396636 0.117381424831067 no 472 0.123126761308619 142 6385573 YIL048W NEO1 SGTC_1187 1391-0724 117 µM 1.1556961010811 0.118120580673672 no 473 0.123902741759642 148 6997986 SGTC_2027 5150920 200 µM 1.15390246065026 0.11847049766478 no 474 0.124270080130881 128 786715 SGTC_3119 9125183 49.47 µM 1.15100671804931 0.119036966162689 no 475 0.124864735876824 116 22695334 SGTC_2177 5811945 192 µM 1.14771255076969 0.119683697033304 no 476 0.125543624117433 156 5343475 SGTC_20 0481-0013 4.944 µM 1.14621671101753 0.119978185991273 no 477 0.125852747532667 174 182045 SGTC_1507 4075-3230 155 µM 1.14511128266354 0.12019614182125 no 478 0.126081531154808 136 659771 SGTC_510 ag-490 170 µM 1.14388490387843 0.120438271555662 no 479 0.126335686219678 137 5328779 SGTC_1757 st041620 31.8375 µM 1.14292921916769 0.12062719489351 no 480 0.126533989917406 133 5289815 SGTC_445 e6 berbamine 66 µM 1.14156021407708 0.120898188318162 no 481 0.126818434810676 169 6610268 A calcium/calmodulin antagonist. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.14070918539581 0.121066864525322 no 482 0.126995481433817 152 688669 SGTC_3164 9100705 49.47 µM 1.14038844366356 0.121130479348621 no 483 0.127062252636883 111 17174235 SGTC_2426 5582046 32.21 µM 1.13601183657903 0.12200087069977 no 484 0.127975805267218 147 2251934 SGTC_248 streptozotocin 5.23457 mM 1.13088792813299 0.123025450557802 no 485 0.129051132455585 171 5300 DNA alkylating agent. SGTC_88 0180-0332 8.668 µM 1.13018047565957 0.123167385704799 no 486 0.129200092503269 165 3101745 SGTC_1811 st050069 61.5 µM 1.12991599008048 0.12322047851806 no 487 0.129255812756395 144 3877702 SGTC_1943 st076331 65.2 µM 1.12979266832921 0.123245239597893 no 488 0.129281799144547 147 24208415 SGTC_2325 6158266 200 µM 1.12699791947774 0.123807316520494 no 489 0.129871680315392 139 3623240 SGTC_1465 k213-0056 144 µM 1.12675501173908 0.123856254493281 no 490 0.129923038169547 174 24048857 YMR208W ERG12 SGTC_1152 3909-8331 15.9 µM 1.12456302578119 0.12429848047965 no 491 0.130387124526479 136 16001939 SGTC_254 nsc-64875 3.808 µM 1.12337076288987 0.124539478766587 no 492 0.130640030825956 130 56993 SGTC_1839 st053978 48 µM 1.12202666589076 0.124811559564637 no 493 0.130925551081784 140 3788398 SGTC_1113 artemisinin 1.17947 µM 1.12079787703432 0.125060662134156 no 494 0.131186954018426 195 2240 An anti-malaria and mitochondrial poison. SGTC_1261 0712-0010 12.7 µM 1.12041002669922 0.125139359990696 no 495 0.131269537063239 156 2840123 SGTC_3220 9131269 49.47 µM 1.11553251609414 0.126131997759037 no 496 0.132311146237653 154 17722206 SGTC_2310 7668677 200 µM 1.10967034747162 0.127332272409991 no 497 0.133570552565608 185 2197143 SGTC_1220 1838-0075 193 µM 1.10682933688676 0.127916816361377 no 498 0.134183860895609 151 5529645 SGTC_2199 6590217 200 µM 1.10650205767018 0.127984274330294 no 499 0.134254636945487 141 703109 SGTC_1996 st072960 66.8 µM 1.10377432967775 0.128547468220347 no 500 0.134845521480639 163 1719405 SGTC_3152 9099253 49.47 µM 1.10190332221567 0.128934768191184 no 501 0.135251852064759 193 25236131 SGTC_2212 7123476 200 µM 1.09436224012543 0.130503978459701 no 502 0.136898068914656 138 1085715 SGTC_604 1000-0114 314 µM 1.08709378826283 0.132028910565468 no 503 0.138497681401183 155 1572745 SGTC_3297 9117502 71.43 µM 1.08613656496702 0.13223064944627 no 504 0.138709288637152 128 7453720 SGTC_2173 5763948 167 µM 1.08412028580461 0.132656283804836 no 505 0.139155734765614 172 2867177 SGTC_3271 9137798 49.47 µM 1.08375450088226 0.132733601630153 no 506 0.139236831836912 140 6498326 SGTC_1107 amlodipine 47 µM 1.0831663878547 0.132857979138209 no 507 0.139367288013035 146 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2045 5106652 78.05 µM 1.08278845170615 0.132937949580998 no 508 0.139451166291674 141 673349 SGTC_2144 5628481 200 µM 1.07778637122611 0.13399950098997 no 509 0.140564551506226 143 2818399 SGTC_1817 st052116 64.4 µM 1.07512832794188 0.134565959867714 no 510 0.141158639130709 136 4361398 SGTC_2540 epiandrosterone 100 µM 1.07084129125847 0.13548303469212 no 511 0.142120398617134 176 441302 A steroid. SGTC_1935 st074532 41.6 µM 1.06611761769136 0.136498462857137 no 512 0.143185238263642 184 2829742 SGTC_315 k915-0449 187 µM 1.06610182652908 0.136501866123237 no 513 0.143188807019126 169 20970215 YNL149C PGA2 SGTC_616 4092-0450 108 µM 1.06410544471506 0.136932588129825 no 514 0.143640467315232 175 787165 SGTC_589 1227-0070 34.1 µM 1.06033211858876 0.137749222819535 no 515 0.144496766068399 161 2841384 SGTC_3048 9093155 49.47 µM 1.05972461471446 0.137881010606828 no 516 0.144634950596526 155 25236002 SGTC_3225 9130819 49.47 µM 1.05487265785947 0.13893664800707 no 517 0.145741784364596 179 4547121 SGTC_1617 st002906 78 µM 1.05451375281901 0.139014952762173 no 518 0.145823883741829 166 5150859 SGTC_2737 bleomycin 30.5 nM 1.05238267622532 0.139480523012879 no 519 0.146312006775024 177 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_3096 9117468 49.47 µM 1.0514602652526 0.139682368015191 no 520 0.146523624813637 148 41316311 SGTC_250 brefeldin a 552.239 µM 1.04862006645079 0.140305116412266 no 521 0.14717650828077 148 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2254 7938975 95.19 µM 1.04860712615137 0.140307958039695 no 522 0.147179487355198 168 2969277 SGTC_264 promethazine 12.5 mM 1.0443786389229 0.141238606988959 no 523 0.14815512128092 215 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2647 atorvastatin 60.16 µM 1.04416131407846 0.141286550882012 no 524 0.148205381042493 155 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_3037 9091026 49.47 µM 1.04118816458049 0.141943563361998 no 525 0.148894113782204 177 25236398 YIL048W NEO1 SGTC_1310 1188-0297 994 nM 1.04048394983843 0.142099484649343 no 526 0.149057558523668 167 1588352 SGTC_1513 0337-0559 19 µM 1.03873555497489 0.142487100539736 no 527 0.149463870258031 164 775073 SGTC_1721 st082152 9.2685 µM 1.03865349896758 0.142505309756132 no 528 0.149482957503526 167 5296051 SGTC_3002 9075603 71.4286 µM 1.03802502288276 0.14264482835868 no 529 0.149629202786699 202 20105405 SGTC_643 k048-0106 28.4 µM 1.03485133286564 0.143350782461265 no 530 0.150369172814803 189 6763920 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.03352401325496 0.143646729298877 no 531 0.150679369404789 145 6708561 SGTC_730 1436-0052 41.2 µM 1.03323962891047 0.143710190871587 no 532 0.150745885843907 149 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_231 b-estradiol 524 µM 1.02825016446733 0.144826688962877 no 533 0.151916083403034 169 450 A steroid. SGTC_1224 0823-0416 294 µM 1.02594879465126 0.14534363230733 no 534 0.152457860472186 164 3598164 SGTC_3346 9158254 43.5805 µM 1.02499502978809 0.145558234344001 no 535 0.152682766421953 200 17639500 SGTC_798 1287-0182 476 µM 1.02017253977703 0.146646580824532 no 536 0.153823319278898 183 1649755 SGTC_3123 9126162 49.47 µM 1.01875300523494 0.146967981051509 no 537 0.154160120735583 160 25239884 SGTC_306 1672-3436 11.6 µM 1.01692346615676 0.147382907675545 no 538 0.154594919571979 180 6797378 SGTC_934 2950-0684 338 µM 1.01576146788575 0.147646847964294 no 539 0.154871494539082 186 1121253 SGTC_3236 9132701 49.47 µM 1.01516001358498 0.147783588633381 no 540 0.155014778982064 177 24282524 SGTC_885 0865-0106 16.8 µM 1.01480025443344 0.147865420415099 no 541 0.155100526223424 173 2793380 SGTC_2207 7258803 200 µM 1.01320639748329 0.148228328265621 no 542 0.155480792680523 184 3666799 SGTC_1816 st051957 91.6 µM 1.01176747211057 0.148556470912794 no 543 0.155824623047819 175 674121 SGTC_3309 9129340 25.759 µM 1.0103007865194 0.148891443682199 no 544 0.15617560222509 177 17158987 SGTC_1451 4152-0210 104 µM 1.00713097921767 0.149617111124637 no 545 0.156935917881836 182 659563 SGTC_1097 itavastatin 7.23 µM 1.00202380012711 0.150791259750379 no 546 0.15816604907593 198 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_972 1319-0219 195 µM 1.00153169187762 0.150904719375588 no 547 0.158284913179318 197 23903702 SGTC_759 3486-0358 89.3 µM 0.995579918888899 0.152281448826074 no 548 0.159727147857821 199 875103 SGTC_3011 9081274 71.4286 µM 0.995423990812683 0.152317628932228 no 549 0.159765047597626 177 6625322 SGTC_2127 5253358 187.912 µM 0.994543369965757 0.152522067139607 no 550 0.159979200952715 161 20612 SGTC_2908 7930301 100 µM 0.992941718903351 0.152894360729115 no 551 0.16036917868209 199 2223178 SGTC_1971 st069429 63.5 µM 0.988137000859578 0.154014799097054 no 552 0.161542778388739 172 1246522 YGL099W LSG1 SGTC_121 0557-0495 61.343 µM 0.988003363284803 0.154046040226113 no 553 0.16157550051831 217 3104427 SGTC_2117 5521686 200 µM 0.985561665933118 0.154617586201413 no 554 0.162174128480566 187 803312 SGTC_1761 st044296 37 µM 0.985192697803829 0.154704075001704 no 555 0.162264713390411 192 1826700 SGTC_1854 st056233 32.9 µM 0.980588086485831 0.155786117612272 no 556 0.163397955827466 196 5393174 SGTC_574 1315-0397 40 µM 0.980169762296113 0.155884666740798 no 557 0.163501163867181 225 6794277 SGTC_193 1273-0060 1.558 µM 0.978849535913822 0.156195956138493 no 558 0.163827164848035 187 2847393 YHR072W ERG7 SGTC_2837 9008476 45.46 µM 0.978175885161213 0.156354950483195 no 559 0.163993670575674 166 2992805 SGTC_32 0928-0142 34.1 µM 0.973799424709673 0.157390472999852 no 560 0.165078069405165 194 2244242 SGTC_2159 5658611 73.75 µM 0.973234881280221 0.157524378187901 no 561 0.165218289172363 172 793844 SGTC_331 k048-0133 24.5 µM 0.971989685929196 0.157819993159908 no 562 0.165527839856864 189 6813582 SGTC_953 1188-0045 9.7 µM 0.971796443684675 0.157865902374529 no 563 0.165575912725522 195 6144426 SGTC_2041 5107442 45.335 µM 0.97026875575273 0.158229149061622 no 564 0.165956273429022 210 793005 SGTC_1873 rapamycin 2 nM 0.967756139331955 0.15882777954054 no 565 0.166583086758967 178 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_492 tmb-8 126 µM 0.965725381405536 0.159312690646387 no 566 0.167090807701945 176 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2623 humulene 100 µM 0.965721341966215 0.159313656162183 no 567 0.167091818617653 167 6187145 An anti-inflammatory. SGTC_1182 1222-0449 220 µM 0.965582610037373 0.159346818502898 no 568 0.167126540256793 191 658318 SGTC_1782 st039423 80.636 µM 0.964503773964487 0.159604856623916 no 569 0.167396708614282 178 2068169 SGTC_652 0437-0092 114 µM 0.964280215098063 0.159658362057349 no 570 0.167452728698373 185 3091274 SGTC_2664 lyso-paf C-16 73.48 µM 0.962100890381904 0.160180565322223 no 571 0.167999463453588 208 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_862 0452-0056 10.2 µM 0.956550966548747 0.161515457946653 no 572 0.169396973968228 191 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_465 cgp-37157 41 µM 0.956546160189672 0.161516617128209 no 573 0.169398187468218 167 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_599 1935-0052 86.5 µM 0.955089529992792 0.161868172226965 no 574 0.169766211612434 169 9557311 SGTC_2593 nobiletin 86.24 µM 0.954737585276073 0.161953188181608 no 575 0.169855208876066 179 72344 An anti-infammatory. SGTC_691 1548-0686 185 µM 0.954069420688262 0.162114670394123 no 576 0.170024251851315 230 46495133 SGTC_2948 9070189 9.45 µM 0.947955570224481 0.16359713487318 no 577 0.171576036569842 174 6473636 YDL196W YDL196W SGTC_1452 4194-0072 190 µM 0.945647039842206 0.164159181149951 no 578 0.172164321550281 193 1343545 SGTC_2993 9054257 71.4286 µM 0.943514976381614 0.164679375002683 no 579 0.172708779306433 212 6470217 YGL055W OLE1 SGTC_1126 isoteolin 1.0172 µM 0.94153033944416 0.165164557559087 no 580 0.173216574519023 181 133323 SGTC_1415 3966-0071 78.1 µM 0.940467843791926 0.165424684874237 no 581 0.173488818220091 198 2893185 SGTC_1293 1000-1278 195 µM 0.939668694998459 0.1656205123948 no 582 0.173693763792036 197 678847 SGTC_1399 3562-5772 25 µM 0.939076245893631 0.1657657858888 no 583 0.173845799606757 185 23847490 SGTC_3075 9116269 49.47 µM 0.936137787728917 0.166487537654207 no 584 0.174601124707299 191 17015205 YNL244C SUI1 SGTC_302 1094-0063 18.9 µM 0.932156094028519 0.16746876353897 no 585 0.175627931115274 218 5440289 SGTC_1066 ketoconazole 628 nM 0.930980428208066 0.167759198976146 no 586 0.17593184417368 211 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_371 0195-0006 7.36 µM 0.929871971497259 0.168033328005237 no 587 0.176218688307208 192 3928593 SGTC_788 1182-0090 188 µM 0.923038729549032 0.169729597705407 no 588 0.177993511231249 196 5715185 SGTC_1194 1488-0194 225 µM 0.922309560791403 0.169911251297495 no 589 0.178183564210525 203 1391452 SGTC_2496 diffractaic acid 79.83 µM 0.92108619723147 0.17021630065454 no 590 0.178502712970977 198 94870 An apoptosis inducer which activates caspases. SGTC_2775 cyproheptadine 69.59 µM 0.917150729386847 0.171199999667168 no 591 0.179531830595433 207 2913 A selective serotonin reuptake inhibitor. SGTC_3243 9134147 49.47 µM 0.915686305235876 0.17156696937014 no 592 0.179915724942244 212 24282180 SGTC_318 1488-0629 67.2 µM 0.914891810526359 0.17176627176458 no 593 0.180124214875819 204 3662576 SGTC_1004 4084-0029 199 µM 0.914011577277159 0.171987254636577 no 594 0.180355381193064 190 716894 YLR208W SEC13 SGTC_2827 7993847 71.43 µM 0.913570859117327 0.172097965245042 no 595 0.180471192227348 180 2985692 SGTC_824 1304-0008 100 µM 0.912544304748809 0.172356017168812 no 596 0.180741128953927 213 768245 SGTC_7 0192-1582 4.227 µM 0.912209486932212 0.172440235946592 no 597 0.180829225402325 235 252616 SGTC_3122 9126309 49.47 µM 0.911608950323285 0.172591358348557 no 598 0.180987304552251 240 17591206 SGTC_1764 st044502 93.5 µM 0.911309439038437 0.172666760600553 no 599 0.181066177210433 189 8407 SGTC_2010 4012422 159 µM 0.911183823141317 0.172698390772765 no 600 0.181099263039664 201 952393 SGTC_70 0141-0289 43.283 µM 0.910008605713825 0.172994490268846 no 601 0.181408985676853 210 352408 SGTC_2610 ononetin 44.17 µM 0.909919761431244 0.173016887990205 no 602 0.181432413615337 196 259632 SGTC_583 1488-1091 88.9 µM 0.909879590552368 0.173027015710377 no 603 0.181443007162776 236 4303273 SGTC_1147 3809-1045 12.3 µM 0.909671890636194 0.17307938620098 no 604 0.1814977863236 188 325925 SGTC_2081 5214970 32.255 µM 0.908621374549524 0.173344423218025 no 605 0.181775009949043 168 2063512 SGTC_2560 caryophyllene 100 µM 0.908601634782035 0.173349405879359 no 606 0.181780221665672 223 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_68 0986-0284 82.829 µM 0.907700474663247 0.173576971490936 no 607 0.182018246555162 201 423278 YIL048W NEO1 SGTC_1364 1653-0028 37.6 µM 0.904553553372896 0.174373138485986 no 608 0.182850975502562 191 5718652 SGTC_1093 fluphenazine 7.97 µM 0.903562136400897 0.17462444552368 no 609 0.183113813107705 216 6602611 An atypical antipsychotic. SGTC_1867 st057372 64 µM 0.903534781652927 0.174631382737358 no 610 0.183121068548719 188 688837 SGTC_2977 9011197 71.43 µM 0.903245147668865 0.174704845175735 no 611 0.183197900666571 221 2704722 SGTC_2995 9067767 71.4286 µM 0.902781765844022 0.174822417618846 no 612 0.183320865228999 170 11673567 SGTC_2747 doxorubicin 7.63 µM 0.901295436404472 0.175199878201808 no 613 0.183715629785193 151 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2274 7947094 46.08 µM 0.901269499802243 0.175206469513093 no 614 0.183722523165723 205 2971028 SGTC_1340 1486-1359 257 µM 0.90095232925399 0.175287085305284 no 615 0.183806833180919 217 4309068 SGTC_1449 4112-4002 201 µM 0.900877027239143 0.17530622840439 no 616 0.183826853440303 185 2059539 SGTC_3 0833-0587 95.581 µM 0.897903545992721 0.176063199210834 no 617 0.184618487021527 204 5382644 SGTC_2731 amoxapine 43.43 µM 0.897528404228216 0.17615884731268 no 618 0.184718511853299 235 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1457 k015-0032 57.3 µM 0.896086546026879 0.176526777065883 no 619 0.185103271022651 208 4302660 SGTC_1346 1488-2224 62.4 µM 0.895297217068158 0.176728401764176 no 620 0.185314113784989 217 3722427 SGTC_3138 9097216 49.47 µM 0.892470185762026 0.177451727212551 no 621 0.186070483120299 235 25237486 SGTC_1665 st014639 11.4 µM 0.890449150708732 0.177969974014277 no 622 0.186612380324655 220 981133 YIL048W NEO1 SGTC_959 1222-0044 107 µM 0.886378451522464 0.179016702577546 no 623 0.187706813471633 208 6083612 SGTC_1614 st002383 48.6 µM 0.884820905537852 0.179418228271079 no 624 0.188126616165563 192 1947235 SGTC_3178 9107506 49.47 µM 0.882969550455223 0.179896231976918 no 625 0.188626361768871 213 8897194 SGTC_576 1073-0113 22.7 µM 0.881461785218223 0.18028611415355 no 626 0.189033964524348 242 5439563 SGTC_3232 9132874 49.47 µM 0.881278058783235 0.180333658869156 no 627 0.189083669392631 206 3784940 SGTC_507 nimesulide 162 µM 0.87760633795249 0.181285475783781 no 628 0.190078694302358 202 4495 A COX2 inhibitor. SGTC_2265 7929201 200 µM 0.875809336152486 0.181752455468955 no 629 0.19056684687622 244 1265108 SGTC_3185 9108267 49.47 µM 0.875481992623265 0.181837601883266 no 630 0.190655852002658 224 4910486 SGTC_818 4072-2707 53.5 µM 0.875083797208368 0.18194121144662 no 631 0.190764156238914 202 882871 SGTC_416 estradiol valerate 100 µM 0.874941572921438 0.181978226836768 no 632 0.190802848637587 231 13791 A steroid. SGTC_2580 diallyl disulphide 81.36 µM 0.874630036140434 0.182059324065594 no 633 0.190887619660397 220 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2845 9003024 42.97 µM 0.873775120276239 0.182281986259882 no 634 0.191120366059604 209 2990173 SGTC_150 3970-0969 77.2 µM 0.873315759347181 0.182401696723031 no 635 0.191245496521209 256 6615640 SGTC_286 k060-0067 22.9 µM 0.872633458728227 0.182579596390887 no 636 0.191431448689171 213 5985051 SGTC_1503 4585-0012 61.3 µM 0.871135493831763 0.18297054824156 no 637 0.191840088007454 197 2922052 SGTC_2354 9060492 162 µM 0.871108228644172 0.182977668983403 no 638 0.191847530795581 228 6471895 SGTC_2256 7954252 200 µM 0.869316664987468 0.183445943557176 no 639 0.192336975088662 211 2972920 SGTC_1819 st053448 58.6 µM 0.86658262651136 0.184161998356654 no 640 0.193085368047875 244 2857616 SGTC_2263 7948595 193.29 µM 0.864848293648467 0.184617127099407 no 641 0.19356103023333 207 2971371 SGTC_2687 chenodiol 100 µM 0.862066891679639 0.185348489599862 no 642 0.194325354599804 208 5702181 A cholesterol synthesis inhibitor. SGTC_2600 tangeritin 87.95 µM 0.861449536503058 0.1855110651687 no 643 0.194495251598274 227 68077 A bioactive flavone. SGTC_2112 5488546 200 µM 0.859242891776397 0.186092890688686 no 644 0.195103262022912 234 600757 SGTC_1409 3909-8004 61.9 µM 0.858263246567317 0.186351555677821 no 645 0.195373559606623 204 2119279 SGTC_190 3970-0790 3.722 µM 0.856523780445148 0.186811391928695 no 646 0.195854062444117 208 2832352 SGTC_2206 7254556 146.969 µM 0.855003501464209 0.187213859579017 no 647 0.196274604661958 196 4398905 SGTC_3097 9117246 49.47 µM 0.848853867329212 0.188847333823972 no 648 0.197981305859054 223 16423892 SGTC_1343 1487-0095 224 µM 0.848697041465747 0.188889104637007 no 649 0.198024946446427 243 4560101 YGL055W OLE1 SGTC_2213 7173844 200 µM 0.847672212730747 0.189162209496855 no 650 0.198310272810872 226 892728 SGTC_2329 6138490 200 µM 0.8458504478476 0.189648288436309 no 651 0.198818089268616 216 720019 SGTC_225 nsc-122657 1.016 µM 0.845459946322538 0.189752581030228 no 652 0.198927043400307 216 275685 SGTC_42 0133-0086 60.653 µM 0.844980500954345 0.189880676391689 no 653 0.199060863024323 262 162923 Model of phenazepam hydroxylation. SGTC_1422 4031-0024 15.5 µM 0.84382041992878 0.190190839823636 no 654 0.199384881492006 247 782427 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.843092570192913 0.190385599172668 no 655 0.199588336858389 230 5282362 SGTC_3160 9100216 49.47 µM 0.84170407273976 0.190757475386381 no 656 0.19997680899623 222 17191039 SGTC_1282 0886-0010 32.4 µM 0.839401914141316 0.191375035536918 no 657 0.200621905044297 229 2836211 YNL267W PIK1 SGTC_143 4032-1194 15.74 µM 0.837792798052117 0.191807411819121 no 658 0.201073542137523 229 1806963 SGTC_2638 epoxomicin 18 µM 0.836412915410168 0.192178668060354 no 659 0.201461324623451 205 9915668 A protesome inhibitor. SGTC_1977 st070720 65.3 µM 0.833430053671401 0.192982705353487 no 660 0.202301115450609 192 682188 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.832449508658534 0.193247461535467 no 661 0.202577633381303 203 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2546 rhodinyl acetate 100 µM 0.832378473682332 0.193266650240934 no 662 0.202597674324056 230 6708682 SGTC_312 4092-0653 6.84 µM 0.832023810890173 0.193362472833061 no 663 0.202697752290974 235 1148278 SGTC_1730 st033808 45.1 µM 0.83085121618842 0.193679490112458 no 664 0.203028842722733 225 1045166 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.830538153822966 0.193764181776222 no 665 0.203117292690575 214 641818 YHR062C RPP1 SGTC_480 am 92016 50 µM 0.830295625514674 0.193829807626459 no 666 0.203185830379654 264 2129 K+ channel blocker. SGTC_202 3594-0513 34.79 µM 0.830197730946608 0.193856300801743 no 667 0.203213498967496 225 708429 SGTC_2101 5377231 179.231 µM 0.829544062612898 0.194033259418062 no 668 0.203398307198155 229 2844213 SGTC_1556 plumbagin 1.48 µM 0.827647188195363 0.194547331003773 no 669 0.203935167992109 235 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2223 6903751 107.57 µM 0.827547361730558 0.194574407894453 no 670 0.203963444636249 233 5598863 SGTC_921 1561-0023 372 µM 0.826256414702952 0.194924770409733 no 671 0.204329326109146 232 24050882 SGTC_1945 st075991 56.6 µM 0.825003603601235 0.195265149389045 no 672 0.20468477240691 209 1084980 SGTC_1361 1608-0041 5.61 µM 0.824150143472188 0.195497234517171 no 673 0.204927125754053 250 X1361 SGTC_2659 sanguinarine 24.21 µM 0.822116687482667 0.196050875738459 no 674 0.205505244438376 239 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1078 idebenone 36.1 µM 0.822096618441605 0.196056344593975 no 675 0.20551095495887 254 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_903 1134-0042 114 µM 0.82207095498107 0.196063338075276 no 676 0.205518257473814 237 701009 SGTC_2729 fluphenazine 10.66 µM 0.817330530405262 0.197357732575515 no 677 0.206869781968255 251 3372 An atypical antipsychotic. SGTC_1255 0566-0045 221 µM 0.81553894285268 0.197848276413471 no 678 0.207381941411562 230 2788469 SGTC_1508 1080-0625 72.9 µM 0.815328180469277 0.197906032382829 no 679 0.207442241096169 229 767111 SGTC_2113 5491891 107.031 µM 0.814138909762504 0.198232123319373 no 680 0.207782688831186 238 789979 SGTC_1992 st073643 23.3 µM 0.811626620432004 0.198922043454621 no 681 0.208502955763756 232 3161292 SGTC_596 1155-0152 116 µM 0.811587478184721 0.198932804061133 no 682 0.208514189381226 251 280313 SGTC_3030 9087619 49.47 µM 0.811165751010337 0.199048763450998 no 683 0.208635245479186 244 25236973 SGTC_1904 st060225 78 µM 0.810862857471766 0.199132073106287 no 684 0.208722216133113 218 66595 SGTC_1037 k284-1091 78.7 µM 0.810776527763921 0.199155821592881 no 685 0.208747008131559 220 3334711 SGTC_3140 9094243 49.47 µM 0.809935859197124 0.199387170755459 no 686 0.208988520422182 264 19291112 SGTC_165 k038-0023 64.381 µM 0.807401233233744 0.200085670000876 no 687 0.209717678333037 225 46368543 SGTC_2140 5586273 200 µM 0.805654761732678 0.200567822306952 no 688 0.210220970305267 218 854421 SGTC_2139 5578692 56.4705 µM 0.803471756039394 0.201171469621962 no 689 0.210851057580903 248 650991 YMR113W FOL3 SGTC_544 k015-0020 52.4 µM 0.803423465512942 0.201184835280119 no 690 0.210865008324857 233 3008304 SGTC_1681 tripelennamine 100 µM 0.800834452237317 0.201902191279577 no 691 0.211613745515263 211 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1482 3346-2049 8.48 µM 0.800117785134955 0.202101033520439 no 692 0.211821278832383 223 3826804 SGTC_2131 toluylene red 5.2905 µM 0.799626962706287 0.202237281810134 no 693 0.21196348046037 203 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1612 st002233 45.4 µM 0.798551922065982 0.202535896204461 no 694 0.212275137460871 239 1035021 SGTC_871 0574-0004 149 µM 0.797711717738259 0.202769463439596 no 695 0.212518901173369 241 9551173 SGTC_2640 pentamidine 10.38 µM 0.79747147790215 0.20283627695338 no 696 0.212588630642566 243 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3288 9119690 36.221 µM 0.796897997280664 0.202995821794905 no 697 0.212755137060522 246 17595618 YKL019W RAM2 SGTC_2059 5238311 157 µM 0.79671124680028 0.203047792774625 no 698 0.212809375293202 254 703021 SGTC_2448 5185112 27.17 µM 0.795595688531715 0.203358408053144 no 699 0.213133536687935 223 5718189 SGTC_1663 st014140 55.4 µM 0.794195069602063 0.20374879662152 no 700 0.213540939177808 226 4207120 SGTC_3087 9117406 49.47 µM 0.793548291727424 0.203929220961804 no 701 0.213729222574566 225 42546093 SGTC_1664 st014217 9.02 µM 0.793017332981693 0.204077407680658 no 702 0.213883862132903 244 3982782 SGTC_2120 5538279 151.968 µM 0.790435075137127 0.204799011127596 no 703 0.214636862413757 221 2058197 SGTC_2700 st077718 96.8 µM 0.789716954540916 0.204999956920644 no 704 0.214846543747606 231 904970 SGTC_2318 6029776 164 µM 0.789370855339333 0.205096844860675 no 705 0.214947642432679 248 818325 SGTC_1117 retinoic acid 1.10837 µM 0.787510797372256 0.205618020464127 no 706 0.215491455126771 240 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2697 mebhydrolin 72.4 µM 0.780878147733208 0.207482832898917 no 707 0.21743708281499 242 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_464 bw-b 70c 158 µM 0.780667117507986 0.207542329035714 no 708 0.217499152635263 249 5353454 SGTC_2262 9014885 67.46 µM 0.779880091745253 0.20776430554695 no 709 0.217730728838476 239 6457424 SGTC_1002 4049-0206 172 µM 0.779859118611729 0.20777022282754 no 710 0.217736901964934 256 4662749 SGTC_1872 amphotericin b 148 nM 0.778163531151123 0.208248938717264 no 711 0.218236306591349 236 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2795 7780010 54.55 µM 0.777157219402251 0.208533358581012 no 712 0.218533009346332 237 953673 SGTC_2285 7945142 200 µM 0.776964983080165 0.208587717518064 no 713 0.218589715058423 253 2970608 SGTC_2661 dactinomycin 12.96 µM 0.776414461983386 0.208743435358109 no 714 0.218752154177155 238 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2988 9073640 71.4286 µM 0.773274910082 0.2096327829477 no 715 0.219679850574376 248 9102229 SGTC_2896 9052656 71.43 µM 0.772137455605373 0.209955541222231 no 716 0.220016510114181 257 6469436 SGTC_1314 1222-0010 41.1 µM 0.771829221159328 0.21004305451913 no 717 0.220107791146029 256 3526027 SGTC_1357 1503-1303 39.5 µM 0.771430711212628 0.210156230413324 no 718 0.220225838697284 229 292895 SGTC_1628 st004252 77.7 µM 0.768372636804093 0.211025907784951 no 719 0.221132916052066 244 692968 SGTC_369 0957-0393 4.5 µM 0.766384229678974 0.211592515496406 no 720 0.221723856783243 262 6997992 SGTC_1042 0350-0096 82 µM 0.765559239892303 0.211827862111224 no 721 0.221969302574251 244 3122515 SGTC_2982 9019404 25.97 µM 0.765538129720832 0.211833886264323 no 722 0.221975585175189 228 22333232 SGTC_2465 5809242 33.21 µM 0.765473351608555 0.211852372446442 no 723 0.22199486443159 269 2731748 SGTC_2324 6149169 200 µM 0.764788470184259 0.212047879573883 no 724 0.222198757263769 239 2888231 SGTC_2497 7-hydroxyflavone 100 µM 0.762240031133078 0.212776286358105 no 725 0.222958379052031 267 5281894 SGTC_3317 9138495 8.753 µM 0.762112207955789 0.212812859806442 no 726 0.222996518652676 263 17020139 SGTC_1424 4048-1941 275 µM 0.761088009652161 0.213106041353135 no 727 0.223302250844402 254 X1424 SGTC_2266 7929956 200 µM 0.757895841433862 0.214021324559551 no 728 0.224256670009908 255 2967153 SGTC_1936 st074407 74.3 µM 0.756906698673026 0.214305402920043 no 729 0.224552880932638 257 809813 SGTC_2086 5274770 176.623 µM 0.756606392937614 0.214391693065615 no 730 0.224642855073395 255 689278 SGTC_3076 9116187 49.47 µM 0.756461384983954 0.214433367026631 no 731 0.224686308004018 232 27241210 SGTC_2707 st078556 66.6 µM 0.756065299783891 0.214547222296889 no 732 0.224805022768919 239 17250899 SGTC_65 0798-0905 34.986 µM 0.755207792805521 0.214793834296516 no 733 0.225062156801282 263 3602145 SGTC_619 1652-1634 108 µM 0.753395293437145 0.215315635911592 no 734 0.2256062051053 250 5400454 SGTC_1947 st076332 61.6 µM 0.753138608177107 0.215389592612003 no 735 0.225683313070196 274 24208416 SGTC_2799 7812892 81.82 µM 0.751616061507166 0.21582857484833 no 736 0.226140990782047 261 20205235 SGTC_2461 5755302 26.15 µM 0.75067250684143 0.216100881548441 no 737 0.226424886472979 273 2788904 SGTC_2975 9084847 53.72 µM 0.750361949287946 0.216190550918725 no 738 0.226518370692966 242 27211724 SGTC_3192 9110362 49.47 µM 0.747720952107588 0.216953973983563 no 739 0.22731424529353 265 16649480 SGTC_614 0462-0418 107 µM 0.747598127437015 0.216989516323612 no 740 0.227351297280095 237 5188303 SGTC_913 3487-1245 167 µM 0.746583085721161 0.217283372407574 no 741 0.227657630741143 246 4016153 SGTC_897 1000-0139 31.4 µM 0.746423151153288 0.217329694652959 no 742 0.2277059192101 260 6151020 SGTC_1068 loratadine 26.9 µM 0.746163958567353 0.217404777352658 no 743 0.227784188537227 263 3957 A H1 histamine antagonist. SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.745032412720665 0.217732738001926 no 744 0.228126062827997 263 688803 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.744487822654321 0.217890680494492 no 745 0.228290702780672 228 803109 SGTC_1812 st052057 4.327 µM 0.744242022652457 0.217961989263417 no 746 0.228365034673332 249 3645418 SGTC_346 4513-0042 7.16 µM 0.744234096162823 0.217964289032566 no 747 0.228367431933744 236 2827372 SGTC_417 st075190 100 µM 0.743745762684269 0.21810599969905 no 748 0.22851514911158 269 222757 SGTC_1186 1319-0216 26 µM 0.743589892670475 0.218151243171146 no 749 0.228562309907964 264 4565136 SGTC_856 0433-0016 11.3 µM 0.74326510652955 0.218245534309482 no 750 0.228660596358431 252 3911780 SGTC_2445 5742597 35.57 µM 0.741927033267082 0.218634248127109 no 751 0.229065772936052 273 1774255 SGTC_2264 7948757 110.76 µM 0.740692877104201 0.218993126809665 no 752 0.229439839574789 251 2971411 SGTC_1949 st076024 69.1 µM 0.740443378523617 0.219065719329938 no 753 0.229515502941476 270 2921930 SGTC_1030 k029-0042 36.7 µM 0.739204704101232 0.219426320981208 no 754 0.229891352406556 242 6080581 SGTC_2823 7987624 58.44 µM 0.738248047462249 0.21970505515664 no 755 0.230181865212709 281 2239440 SGTC_2741 miltefosine 3.04 µM 0.738201180161858 0.219718715767109 no 756 0.230196102920012 232 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1804 st050076 49.1 µM 0.737977350765731 0.219783962994304 no 757 0.230264106321186 249 3895976 SGTC_2370 9071495 200 µM 0.736009497347481 0.220358079239422 no 758 0.230862458992678 270 21791103 SGTC_902 1120-0002 2.07 µM 0.73393386106265 0.220964571422783 no 759 0.231494524303419 253 3280475 SGTC_1326 1431-2094 10.8 µM 0.731435442773917 0.221695864366217 no 760 0.23225661157051 269 616278 SGTC_1799 st045822 46.1415 µM 0.730870835837318 0.221861317511136 no 761 0.23242902561262 259 3674992 SGTC_1272 0839-0021 27 µM 0.729368766167688 0.222301829157743 no 762 0.232888059105582 266 5027250 SGTC_1076 itraconazole 331 nM 0.728714825426088 0.222493766022057 no 763 0.233088061077605 251 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_51 1013-0126 23.419 µM 0.728516679070377 0.222551942220242 no 764 0.233148681202791 256 1627850 SGTC_2751 anetholtrithion 17.25 µM 0.72825680807948 0.222628254049732 no 765 0.233228198387676 260 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_3325 9138760 55.175 µM 0.726406814142331 0.223171940735841 no 766 0.233794707552749 254 43844959 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.725274619305279 0.223505049076245 no 767 0.234141786556305 253 688667 SGTC_2286 7945697 125 µM 0.722019655980489 0.22446428077466 no 768 0.235141196405372 259 1245733 SGTC_694 1315-0438 43.2 µM 0.721410209614937 0.224644142804207 no 769 0.235328583440563 255 6793154 SGTC_2269 7935389 174.42 µM 0.72128781316412 0.224680274745412 no 770 0.235366226727685 257 97605 SGTC_178 4092-0806 87.505 µM 0.720676701902592 0.224860726636152 no 771 0.235554225003484 251 2169044 SGTC_3341 9147222 25.867 µM 0.717548800974577 0.225785633841322 no 772 0.236517768011216 268 1939759 SGTC_1 0258-0098 57.368 µM 0.716372230331826 0.226134097004617 no 773 0.236880768615684 241 6790032 YDR047W HEM12 SGTC_1500 4488-1866 171 µM 0.71610295057426 0.226213891904325 no 774 0.236963891010047 286 2900003 SGTC_1000 4048-0884 8.67 µM 0.715855628968083 0.226287194021755 no 775 0.237040249393828 275 13040088 SGTC_1227 3909-8010 46.6 µM 0.715563657137037 0.226373747010399 no 776 0.237130410545841 250 15982272 SGTC_1165 k072-0275 30.3 µM 0.71257266046105 0.227261482990688 no 777 0.23805511720658 263 6153523 YGL055W OLE1 SGTC_2951 9072950 58.06 µM 0.712392172736593 0.227315114930598 no 778 0.2381109805625 275 16488155 SGTC_728 3030-5151 22.5 µM 0.71162987813546 0.227541709473943 no 779 0.238347000126836 263 3125388 SGTC_2298 7976326 193.81 µM 0.709817490355523 0.22808095801337 no 780 0.238908660748635 243 2235818 SGTC_1769 st044406 64.4 µM 0.708973912451663 0.228332196743491 no 781 0.239170332949075 288 670903 SGTC_3290 9121031 71.43 µM 0.708707071904373 0.228411700943026 no 782 0.23925313769043 268 17014854 SGTC_1300 1094-0077 113 µM 0.7086985890758 0.22841422862695 no 783 0.239255770299952 265 5532636 SGTC_1089 terbinafine 2.25 µM 0.708019696845166 0.228616573543593 no 784 0.239466512906936 272 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1325 1431-0015 227 µM 0.704719344609493 0.2296016817635 no 785 0.240492455189496 247 1103340 SGTC_2405 ticlatone 3.52 µM 0.702960099880131 0.2301277614013 no 786 0.241040307689041 251 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1574 spiramycin 23.7 µM 0.70215637609689 0.230368328959516 no 787 0.241290823759313 279 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1270 0831-1170 17.3 µM 0.702029803052457 0.230406227134866 no 788 0.241330288738711 269 6764716 SGTC_1986 st071812 45 µM 0.701036561553039 0.230703741913718 no 789 0.241640099257004 280 11838594 SGTC_2552 juarezic acid 87.02 µM 0.699458566666998 0.231176854289519 no 790 0.242132748944784 262 1549512 SGTC_125 0133-0007 11.75 µM 0.698551902371686 0.231448933893068 no 791 0.242416055500041 269 26541 SGTC_2189 6047310 154.431 µM 0.69766756658413 0.231714484883796 no 792 0.242692557952366 269 711535 SGTC_3035 9091303 49.47 µM 0.697382869186783 0.231800010778631 no 793 0.242781609697143 281 25237002 SGTC_1403 3909-7815 62.9 µM 0.694767352832601 0.232586559954222 no 794 0.243600555457808 269 6615483 SGTC_443 clozapine 122 µM 0.693869183849054 0.232857003008186 no 795 0.243882125363274 279 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_184 1494-0393 24.714 µM 0.691508817973205 0.233568552814424 no 796 0.24462292058873 282 3090647 SGTC_733 4069-0007 56.1 µM 0.689007183117196 0.234324003542875 no 797 0.24540937363109 273 5717425 YNL287W SEC21 SGTC_3263 9137018 49.47 µM 0.68645675380888 0.235095579508028 no 798 0.246212563129303 276 43844957 SGTC_2492 derrusnin 100 µM 0.685850796261205 0.235279104660426 no 799 0.246403600274665 290 1715307 Part of coumarin class of compounds. SGTC_1377 2944-0135 198 µM 0.683853095997674 0.235884704005506 no 800 0.247033967290228 261 1894137 SGTC_2780 5215298 71.43 µM 0.683799224810372 0.235901046851017 no 801 0.247050978085091 288 2834131 SGTC_1306 1185-0270 9.02 µM 0.683340790392733 0.236040146869653 no 802 0.247195762338835 281 1548076 SGTC_2742 clothiapine 36.27 µM 0.681772392629005 0.236516378060961 no 803 0.247691441817926 258 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.681720684379487 0.236532087847843 no 804 0.247707792827275 269 1609 A potent and irreversible inhibitor of serine proteases. SGTC_3183 9108214 49.47 µM 0.679488881782752 0.237210691861095 no 805 0.24841407497285 258 4974831 SGTC_2868 9035608 32.47 µM 0.678457524207715 0.237524648354708 no 806 0.248740823349757 273 6462614 SGTC_2531 methyl deoxycholate 70.07 µM 0.678446894989617 0.237527885191539 no 807 0.248744192024447 286 16667744 Haematoxylin. SGTC_1781 st038725 66.3 µM 0.678026340404427 0.237655972982146 no 808 0.24887749616508 282 4270275 YIL048W NEO1 SGTC_2382 9035899 200 µM 0.677663808888919 0.237766419166455 no 809 0.248992439113098 287 6462679 SGTC_3176 9106582 49.47 µM 0.677480227142755 0.237822358566918 no 810 0.249050655658391 243 17018027 SGTC_1188 1403-0014 4.57 µM 0.677420266831085 0.237840630704547 no 811 0.249069671547894 268 9614867 SGTC_1645 Cervolide 78 µM 0.676512146746671 0.238117462786159 no 812 0.249357768322615 287 23173 A fragrance. SGTC_1023 4482-3888 16 µM 0.675039803642793 0.23856666805559 no 813 0.249825238330492 281 3303168 SGTC_3127 9126946 49.47 µM 0.675000808372013 0.238578571639396 no 814 0.249837625678586 261 27243249 SGTC_3194 9111903 49.47 µM 0.674356358829369 0.238775341519443 no 815 0.250042390558148 290 17087251 SGTC_1958 st076513 41.9 µM 0.673846702116151 0.238931017930361 no 816 0.250204389922576 286 732122 YGL099W LSG1 SGTC_2584 androsterone 48.74 µM 0.673676246569425 0.238983096551162 no 817 0.250258583301651 249 2754130 A steroid. SGTC_1103 duloxetine 36.1 µM 0.673347648346927 0.239083509401264 no 818 0.250363072958493 278 60835 A selective serotonin reuptake inhibitor. SGTC_2619 obliquin 87.91 µM 0.673255041037888 0.239111812452798 no 819 0.250392524969289 276 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.673250433848378 0.23911322057006 no 820 0.250393990247109 278 94937 An inhibitor of serotonin biosynthesis. SGTC_3355 9151058 44.0485 µM 0.673173500613732 0.239136734710514 no 821 0.250418458886028 280 17015728 SGTC_767 0929-0023 86 µM 0.672649090245611 0.239297050974846 no 822 0.250585281520311 292 1204563 SGTC_2989 9073649 71.4286 µM 0.672634219489487 0.239301597934761 no 823 0.250590012984351 297 21367202 SGTC_2591 skatole 100 µM 0.672373068609578 0.239381456481198 no 824 0.250673111697307 291 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1496 4469-0713 57.4 µM 0.669380190049966 0.240297701236385 no 825 0.251626492558105 291 746691 SGTC_3100 9120536 49.47 µM 0.669360219274908 0.240303821533124 no 826 0.251632860671078 278 16421196 SGTC_472 calcifediol 10 µM 0.667182736210599 0.240971647978638 no 827 0.252327708523759 282 5283731 A vitamin D metabolite. SGTC_3071 9117417 49.47 µM 0.667099833994402 0.240997093729837 no 828 0.252354183090186 286 45595590 YGL055W OLE1 SGTC_2294 7971431 200 µM 0.667002602034049 0.241026939670493 no 829 0.252385235681792 317 5741572 SGTC_1952 st077036 64.1 µM 0.664243632283008 0.241874659289928 no 830 0.253267195796462 283 2937007 SGTC_2713 st079149 53.4 µM 0.664113616946096 0.24191464760766 no 831 0.253308797755709 281 3103253 SGTC_2087 5276107 200 µM 0.662918004868827 0.242282545503835 no 832 0.25369153486301 283 144405 SGTC_2330 7979373 200 µM 0.662259690228803 0.242485242725392 no 833 0.253902402887109 269 1863007 SGTC_1018 4259-0013 28.1 µM 0.662103489820289 0.24253335081941 no 834 0.253952449713245 284 6801262 SGTC_1365 1672-3266 55.4 µM 0.660534261084335 0.243016943576572 no 835 0.254455519855501 285 6415873 SGTC_35 0133-0054 64.071 µM 0.655540386684631 0.244559381939956 no 836 0.256059946335067 284 99677 SGTC_1046 2001-0062 216 µM 0.655459876777935 0.244584291836805 no 837 0.256085855622607 295 739778 SGTC_3182 9108849 49.47 µM 0.655395430382558 0.244604232641696 no 838 0.256106596418172 274 17133045 SGTC_2369 9071472 200 µM 0.655144889230484 0.244681762630055 no 839 0.256187236446926 292 17296037 SGTC_362 0310-0100 9.03 µM 0.653742990554624 0.245115824395101 no 840 0.256638700511545 264 790235 SGTC_265 mycophenolic acid 32.932 µM 0.653631602819043 0.245150330485202 no 841 0.256674589307395 290 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_220 paclitaxel 373.376 µM 0.653516517893629 0.245185984647547 no 842 0.25671167207134 273 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_848 0368-0089 85.6 µM 0.650564157600391 0.246101600279929 no 843 0.257663936907954 291 762535 SGTC_795 0685-0265 78 µM 0.649629781958794 0.246391759840916 no 844 0.257965695385436 275 302754 SGTC_1807 st050092 58.9 µM 0.644624213925767 0.247949298325926 no 845 0.259585369692012 290 5008496 SGTC_625 k213-0058 121 µM 0.644079504937654 0.248119107053551 no 846 0.259761939883972 291 3655420 SGTC_3229 9132204 49.47 µM 0.643957393489558 0.248157182843727 no 847 0.259801531434369 298 17682924 SGTC_1101 ebselen 5.29 µM 0.643839654304997 0.248193898261358 no 848 0.259839708337007 299 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1495 4469-0029 237 µM 0.643590298489577 0.248271666159517 no 849 0.259920571455811 282 793680 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.643442385126758 0.248317802809563 no 850 0.259968544129046 309 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2646 retinol 96.75 µM 0.639590112263581 0.249520999087827 no 851 0.261219556202454 294 445354 A vitamin A analog and teratogen. SGTC_1557 sumaresinolic acid 42.3 µM 0.638849573521734 0.249752649072688 no 852 0.261460397548211 288 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1374 2889-5571 141 µM 0.638380432262226 0.249899461522227 no 853 0.261613032756731 287 2853281 SGTC_3177 9107506 49.47 µM 0.638306786914337 0.24992251215971 no 854 0.261636997438667 286 8897194 SGTC_2812 7970281 58.44 µM 0.637697604245375 0.250113226652844 no 855 0.261835272691 305 2233435 SGTC_3124 9127567 49.47 µM 0.637585502772596 0.250148330241464 no 856 0.261871767592255 286 17592030 SGTC_3208 9114115 49.47 µM 0.637261020087879 0.250249953863251 no 857 0.26197741840448 295 650895 SGTC_1622 st003707 19.4 µM 0.636892655325728 0.250365347290271 no 858 0.262097383600029 286 10140899 SGTC_2940 9060638 45.86 µM 0.636329548475191 0.250541799849852 no 859 0.262280824768691 285 4027022 SGTC_1766 st045414 44.774 µM 0.635877665994323 0.250683447294123 no 860 0.262428080347743 316 253960 SGTC_1302 1159-0335 255 µM 0.634778390419377 0.251028204103944 no 861 0.262786479479541 283 649284 SGTC_2070 5230947 200 µM 0.634474540107071 0.251123542428257 no 862 0.262885588580745 311 2835538 SGTC_392 N-ethylmaleimide 8.33 µM 0.634132150078318 0.251230996206404 no 863 0.262997291363585 286 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2412 st077135 33.4 µM 0.633027908403294 0.251577710846172 no 864 0.263357709094022 318 13258915 SGTC_247 mechlorethamine 29.705 µM 0.630358779761648 0.252416818400146 no 865 0.26422993669017 285 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2829 7992743 58.44 µM 0.629597777346349 0.252656328551935 no 866 0.264478889078891 276 16462845 SGTC_2653 dihydrofissinolide 100 µM 0.628058637022452 0.253141107525432 no 867 0.264982764097489 292 6857746 SGTC_284 0988-0104 32.6 µM 0.627853793590438 0.253205663390636 no 868 0.265049861336961 299 4666532 SGTC_2375 9072683 200 µM 0.627268055013005 0.253390305112855 no 869 0.265241769833465 297 16798029 SGTC_1350 1495-0454 146 µM 0.624121216662501 0.254383489593732 no 870 0.266273990612761 289 1069057 SGTC_1866 st057638 64 µM 0.622764044817139 0.254812460143051 no 871 0.2667197945938 291 688802 SGTC_896 0964-0007 44.5 µM 0.622443475348562 0.254913839975714 no 872 0.26682515034674 297 6756758 SGTC_466 geldanamycin 89.2 µM 0.62197438024701 0.255062228953492 no 873 0.266979357216223 275 5288382 HSP90 inhibitor. SGTC_962 1254-0300 21.5 µM 0.620982261612016 0.255376214882132 no 874 0.267305647191852 284 7340576 SGTC_2879 9041815 71.43 µM 0.620891447753573 0.255404965760911 no 875 0.267335524285194 275 4942971 SGTC_704 1310-0270 142 µM 0.620173456288521 0.255632335162781 no 876 0.267571797511381 313 5718033 SGTC_717 1532-0246 73.2 µM 0.618353473272084 0.256209150139617 no 877 0.26817118016249 287 9561992 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.615791103940917 0.25702240156665 no 878 0.26901619976231 300 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1443 4112-3303 14 µM 0.614586451317598 0.257405200846969 no 879 0.269413932130799 307 704433 SGTC_1414 3917-0015 5.4 µM 0.612617052597774 0.258031648886212 no 880 0.270064790049675 304 6618702 SGTC_1020 4335-0961 93.3 µM 0.611728774671462 0.258314460650334 no 881 0.270358610328013 331 669075 SGTC_673 1082-0474 110 µM 0.611301217548827 0.25845064441673 no 882 0.270500092549564 311 3098046 SGTC_1776 st049249 45.9 µM 0.609626852665424 0.258984314140464 no 883 0.271054509722274 294 1822314 SGTC_2396 5342950 42.78 µM 0.608888757118483 0.259219747942975 no 884 0.271299088437246 294 1886677 SGTC_414 piperonyl butoxide 100 µM 0.60836086234374 0.259388200844269 no 885 0.27147408150382 303 5794 A potent inhibitor of cytochrome P450. SGTC_2752 diclazuril 33.15 µM 0.605197544855811 0.260398808988866 no 886 0.272523873470177 296 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2701 st077767 14.721 µM 0.603982366285924 0.260787569450083 no 887 0.272927682972012 303 5721188 SGTC_2058 5236698 133 µM 0.603815459422184 0.260840989681665 no 888 0.272983170067072 296 766665 SGTC_571 k831-0106 44.2 µM 0.603552462588865 0.260925175902372 no 889 0.273070612992007 324 4783639 SGTC_2822 7994718 71.43 µM 0.603462568444501 0.260953954541449 no 890 0.27310050477452 337 1018011 SGTC_908 3448-7491 47.7 µM 0.602860584555415 0.261146715234989 no 891 0.273300719455576 259 1203031 SGTC_2891 9063876 19.48 µM 0.600868173645254 0.26178522477197 no 892 0.273963896303101 296 6472478 SGTC_2973 9094665 17.96 µM 0.600777055557649 0.261814444597571 no 893 0.273994244098958 305 25237061 YIL048W NEO1 SGTC_2198 6589944 200 µM 0.600353418241078 0.261950318938083 no 894 0.274135362584975 283 5290268 SGTC_764 1951-2361 146 µM 0.600186930149569 0.262003727007992 no 895 0.274190831518595 311 5438930 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.598826541771718 0.262440337963227 no 896 0.274644280500232 308 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_827 3253-0474 693 µM 0.598353819872475 0.262592143243604 no 897 0.27480193621314 302 5402065 SGTC_201 4262-0159 12.803 µM 0.597363776818812 0.262910221518975 no 898 0.275132266261074 303 1341029 SGTC_2696 st077691 74.316 µM 0.595717652413964 0.263439519488368 no 899 0.275681931777049 330 757133 SGTC_290 2043-6722 48.1 µM 0.595373972151435 0.263550095692475 no 900 0.275796759829356 305 773758 YLR208W SEC13 SGTC_868 0527-0199 213 µM 0.595193548286766 0.263608155017054 no 901 0.275857051199295 293 2849450 SGTC_2739 tacrine 100.86 µM 0.594295998218721 0.263897078228278 no 902 0.276157077361252 297 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.593459048880919 0.264166639312657 no 903 0.276436990610698 313 5377381 SGTC_810 3825-7150 143 µM 0.592460340907931 0.264488482359501 no 904 0.27677118514336 274 22330411 YGL099W LSG1 SGTC_1244 0416-0015 52.5 µM 0.591616828709102 0.264760467454766 no 905 0.277053601088964 309 96201 SGTC_3206 9114350 49.47 µM 0.58910768323308 0.26557036513934 no 906 0.2778945198234 284 17087243 SGTC_387 norethindrone acetate 66.7 µM 0.588563151994927 0.26574629380089 no 907 0.278077179219529 312 541197 SGTC_1481 3346-2004 36 µM 0.588471381921186 0.265775948947227 no 908 0.278107968648942 329 2770522 SGTC_2466 5983409 37.09 µM 0.585165013314491 0.266845507003069 no 909 0.279218383693088 322 2879657 SGTC_2571 chrysanthemic acid 100 µM 0.5840689224795 0.267200554456132 no 910 0.279586971246321 331 2743 An insecticide. SGTC_1483 3453-0561 55.9 µM 0.583002453281459 0.267546235527825 no 911 0.279945824356952 319 4546991 SGTC_1610 st001799 48.1 µM 0.58266004879761 0.267657268950283 no 912 0.280061086388255 303 621897 SGTC_1674 st016616 23.6 µM 0.582540045053477 0.267696188733015 no 913 0.28010148813428 299 625830 SGTC_3195 9113082 49.47 µM 0.582509494332468 0.267706097441178 no 914 0.280111774118358 307 17018038 SGTC_880 0833-0487 87.2 µM 0.580512099851884 0.268354325806791 no 915 0.280784664747293 323 76075 SGTC_1056 3448-1962 115 µM 0.580305329301528 0.268421475560118 no 916 0.280854367098729 315 715507 SGTC_2946 9065502 71.43 µM 0.578687729357754 0.268947090530216 no 917 0.281399948541884 278 16489101 SGTC_2235 salicylic acid 500 µM 0.576267441263201 0.269734490790322 no 918 0.282217213201145 300 338 A COX inhibitor and kinase inhibitor. SGTC_2534 helenine 20.12 µM 0.576123373151456 0.269781397323411 no 919 0.282265897037788 314 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1332 1480-0653 17.5 µM 0.575697573478805 0.26992005552732 no 920 0.282409807887522 308 5749438 SGTC_2016 5121758 140 µM 0.575688953291691 0.269922862989559 no 921 0.282412721684084 311 2795203 SGTC_646 4092-0839 27.3 µM 0.574217537228604 0.270402294618826 no 922 0.282910301667121 333 877796 SGTC_289 k017-0060 526 µM 0.573532701598552 0.270625579724117 no 923 0.283142031917357 312 5512909 SGTC_2205 7238770 200 µM 0.572293780105351 0.271029753878899 no 924 0.283561481422555 312 279867 SGTC_316 k060-0003 58.6 µM 0.57218408550904 0.27106555412231 no 925 0.283598633989875 316 6152314 SGTC_674 0498-0004 451 µM 0.5706495148894 0.27156662815246 no 926 0.284118623539869 311 4231473 SGTC_534 k292-0788 63.4 µM 0.568879304956151 0.272145216427478 no 927 0.284719025318459 346 4146317 SGTC_2786 7743617 45.45 µM 0.568430054094496 0.272292150272212 no 928 0.284871493942743 306 583674 SGTC_118 0083-0097 135.343 µM 0.567271775364301 0.27267116343232 no 929 0.285264774965541 338 5207356 SGTC_49 0717-0965 32.132 µM 0.566441605588465 0.272942973420735 no 930 0.285546809188789 339 5889349 YGL099W LSG1 SGTC_2114 5491910 81.25 µM 0.564805720366933 0.273478979600145 no 931 0.286102957877155 338 2849228 SGTC_2364 9055074 200 µM 0.564307253713199 0.27364240826891 no 932 0.286272522844264 316 6470630 SGTC_261 5-fluorouridine 15.376 µM 0.563398838974519 0.273940367878135 no 933 0.286581663802805 288 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_131 0141-0277 33.849 µM 0.561872648265784 0.274441318487538 no 934 0.287101395175674 336 1547771 SGTC_1460 k062-0059 9.15 µM 0.561255984417148 0.274643857878107 no 935 0.287311521369847 303 1373085 SGTC_2401 5128683 200 µM 0.560014248823848 0.275051921734179 no 936 0.287734859367049 330 708373 SGTC_471 1-acyl-paf 4 µM 0.559817514280915 0.275116600780801 no 937 0.287801958014779 303 16759367 SGTC_2481 5478948 45.16 µM 0.559047480477903 0.275369831445675 no 938 0.288064658226901 308 77792 SGTC_1731 st035964 63 µM 0.558951709900097 0.275401334245803 no 939 0.28809733866611 333 6739575 SGTC_2505 galangin 7.89 µM 0.558916235802281 0.275413003555308 no 940 0.288109444175433 343 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3077 9117319 49.47 µM 0.557813735080692 0.275775795653538 no 941 0.288485791316614 333 17154678 SGTC_139 0099-0334 718.624 µM 0.556671751765598 0.276151827462096 no 942 0.288875860248386 320 97690 SGTC_2941 9056145 11.23 µM 0.555972091172072 0.276382335688507 no 943 0.289114966916777 320 2119517 SGTC_2175 5807670 165.306 µM 0.555297015146568 0.276604833773261 no 944 0.289345760074953 294 241186 SGTC_408 cantharidin 100 µM 0.554441802363758 0.276886829072329 no 945 0.289638262138666 306 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_745 0469-0705 296 µM 0.553468804425547 0.277207833603111 no 946 0.289971218076882 338 3486736 SGTC_2906 7926292 26.41 µM 0.550651476355984 0.278138331813454 no 947 0.29093630701339 338 2966319 SGTC_1124 fisetin 1.16336 µM 0.550064576127124 0.278332362921867 no 948 0.291137541195657 327 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2296 7971656 126.45 µM 0.549370682805978 0.27856185137314 no 949 0.291375544593325 311 666570 SGTC_2075 5212009 200 µM 0.548795042180401 0.278752300516338 no 950 0.291573056528595 337 780898 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.546119999140757 0.279638161966865 no 951 0.292491726681474 311 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.541317108658509 0.281232097566712 no 952 0.294144515042416 331 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2335 9018011 154.17 µM 0.540640690932618 0.281456932300468 no 953 0.29437763267597 326 6458208 SGTC_1196 1588-0294 184 µM 0.537561533150085 0.28248150921326 no 954 0.295439896479368 341 6144269 SGTC_1550 gossypolone 36.6 µM 0.536158797920207 0.282948857405711 no 955 0.295924403215714 319 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_945 3381-0768 11.3 µM 0.534837126013272 0.283389537188799 no 956 0.296381244116307 332 1126236 YIL048W NEO1 SGTC_2650 prasterone 100 µM 0.533789768902528 0.283738986816391 no 957 0.296743496527296 301 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_3026 9090633 49.47 µM 0.533315865360652 0.283897172027148 no 958 0.296907473491961 323 25236842 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.533267997589095 0.283913152253052 no 959 0.296924038686422 355 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1573 oleylamine 1.06 µM 0.533140397518115 0.283955752494685 no 960 0.296968198228635 328 5356789 An amine of the fatty acid oleic acid. SGTC_2363 9053361 176 µM 0.533140275722287 0.283955793158598 no 961 0.296968240380893 350 6469797 YMR079W SEC14 SGTC_1008 4106-0037 6 µM 0.531739179065893 0.284423760901208 no 962 0.297453326243463 342 2905394 SGTC_2237 6667747 47.222 µM 0.529485258231394 0.285177345050904 no 963 0.29823443408619 361 729940 YDL015C TSC13 SGTC_357 1325-0123 420 µM 0.527813198844384 0.28573700158774 no 964 0.298814497650401 350 1098503 SGTC_2714 st079313 56.9 µM 0.525725153195222 0.286436625983423 no 965 0.299539592348598 321 2939799 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.525573531559473 0.286487460248377 no 966 0.299592275517538 357 7104 SGTC_167 3672-0051 66.205 µM 0.524180705354804 0.286954633971971 no 967 0.300076429797487 340 3237971 SGTC_1316 1272-0050 65.9 µM 0.523120970943962 0.287310325549953 no 968 0.300445036390825 327 7340392 SGTC_117 lucigenin 22.078 µM 0.521438061658518 0.287875609215913 no 969 0.301030821331412 342 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1397 3532-0190 20.1 µM 0.518918113407652 0.288723032219821 no 970 0.30190892292515 317 5322280 SGTC_3270 9137563 49.47 µM 0.518393740504538 0.288899518959916 no 971 0.302091790554006 320 17015724 SGTC_1172 0370-0043 85 µM 0.517970598929423 0.289041971554449 no 972 0.302239391437344 325 376585 SGTC_1104 tacrolimus 29.8 µM 0.514869983041534 0.290086815128794 no 973 0.303321938850751 345 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_395 anisomycin 6.25 µM 0.514569049437495 0.290188317714048 no 974 0.303427098853884 356 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_141 0443-0274 32.331 µM 0.513349870761868 0.290599707454949 no 975 0.303853302362616 302 1627241 SGTC_2978 9011784 42.97 µM 0.51190852209982 0.291086416107954 no 976 0.304357516766221 336 2994934 SGTC_531 3788-1495 174 µM 0.511504411593679 0.291222942778081 no 977 0.304498950045065 338 2896655 SGTC_23 0213-0011 39.996 µM 0.511206352200138 0.291323659773564 no 978 0.304603285587443 326 627608 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.511091779110675 0.291362379393326 no 979 0.304643396071101 356 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_3210 9128157 49.47 µM 0.510737914054803 0.291481982149038 no 980 0.304767294253059 345 17590849 SGTC_2477 5967686 25.23 µM 0.510304525809149 0.291628494116053 no 981 0.304919066264561 340 776118 SGTC_804 1595-0054 20.9 µM 0.510078842297925 0.291704802658979 no 982 0.304998113636138 337 761523 Stimulates phospholipase C. SGTC_2204 7233102 200 µM 0.5093967865469 0.291935477203571 no 983 0.305237064163877 346 2172480 SGTC_3038 9091290 49.47 µM 0.509211537146723 0.291998144110484 no 984 0.305301978541056 362 25236843 SGTC_2103 5378138 10 µM 0.509129826817086 0.292025787397522 no 985 0.305330613104567 337 244142 SGTC_486 niguldipine 82 µM 0.508131799316191 0.292363526713881 no 986 0.305680457900508 342 1236 A calcium channel blocker. SGTC_91 0417-1751 58.384 µM 0.506980010853662 0.292753525396635 no 987 0.306084422046099 333 6795624 SGTC_647 0140-0236 81 µM 0.505530142788329 0.293244797798814 no 988 0.306593266379812 337 990837 SGTC_2517 totarol 10 µM 0.503147771725378 0.294052867767654 no 989 0.307430190922431 310 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_179 1273-0063 6.77 µM 0.502640362467996 0.294225107403231 no 990 0.307608573067093 364 3108139 SGTC_1784 st039334 36.3 µM 0.501489304199146 0.294616005824605 no 991 0.308013401724337 353 3496984 SGTC_186 3455-3465 67.277 µM 0.500678250150163 0.294891582898049 no 992 0.308298790868529 345 755278 SGTC_1249 0481-0015 10.2 µM 0.499079733006908 0.29543506890893 no 993 0.308861607331576 350 4227577 SGTC_2072 5231554 129 µM 0.496120825410778 0.296442293143208 no 994 0.309904583491192 331 789545 SGTC_613 3914-0030 117 µM 0.495843719321075 0.296536701734621 no 995 0.310002338328612 329 1145395 SGTC_474 dl-dihydrosphingosine 5 µM 0.495816891225221 0.296545842657544 no 996 0.310011803201095 305 3058739 A sphingolipid protein kinase C inhibitor. SGTC_3281 9140613 49.47 µM 0.493941578893042 0.297185122503244 no 997 0.310673719511884 305 16013766 SGTC_22 0964-0034 14.468 µM 0.493815881263826 0.29722799439666 no 998 0.31071810810928 350 138402 SGTC_3157 9099274 49.47 µM 0.49342274561657 0.297362100049006 no 999 0.310856956990931 335 17217662 SGTC_151 3013-0144 2.285 µM 0.492210250234121 0.297775878049262 no 1000 0.311285359495384 365 906558 YHR107C CDC12 SGTC_2391 6285546 200 µM 0.491955121026023 0.297862977261192 no 1001 0.311375535096714 336 846083 SGTC_993 3909-8757 62.7 µM 0.491660216629385 0.297963669898883 no 1002 0.311479783369976 329 4288324 YLR208W SEC13 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.491050188459798 0.298172008139591 no 1003 0.311695475404291 338 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2218 6965428 192.983 µM 0.489839604414265 0.29858564598146 no 1004 0.31212370158971 331 675684 SGTC_2311 7694451 200 µM 0.48970081546155 0.298633084690151 no 1005 0.312172812366163 368 2163142 SGTC_232 clozapine 119 µM 0.489046784393764 0.298856681662217 no 1006 0.312404287614645 349 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_893 0958-0369 48.9 µM 0.486284666832334 0.299801818860222 no 1007 0.313382674511125 371 6819948 SGTC_2384 9036245 200 µM 0.485670774540215 0.300012063283047 no 1008 0.313600303945709 319 6462766 SGTC_3133 9127736 49.47 µM 0.484700062384058 0.300344646618048 no 1009 0.313944561119177 346 27243420 SGTC_2932 9016711 44.54 µM 0.483064884688262 0.300905264095671 no 1010 0.314524833152901 349 7117328 SGTC_1372 2752-0194 270 µM 0.482363763232792 0.301145786681507 no 1011 0.314773779157546 322 823334 SGTC_373 0844-0104 25.9 µM 0.480769795349584 0.301692925950235 no 1012 0.315340059813917 352 5375804 SGTC_1900 st060200 72.8 µM 0.480672512066186 0.301726333503536 no 1013 0.315374635206166 338 688945 SGTC_551 k048-0028 34.9 µM 0.480330991268742 0.301843626574841 no 1014 0.315496027703293 349 6836383 SGTC_450 aminopyrene 156 nM 0.479331058187249 0.302187164782951 no 1015 0.315851565259434 362 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_256 clotrimazole 625 nM 0.478887360258484 0.302339658366509 no 1016 0.316009381707021 335 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2052 5265182 7.135 µM 0.478856463105638 0.302350278627784 no 1017 0.316020372592667 351 1239884 SGTC_255 tunicamycin 200.472 nM 0.476022489720718 0.303325109391698 no 1018 0.317029177864491 329 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3343 9148379 18.9835 µM 0.475399818154896 0.303539484179053 no 1019 0.317251012030201 343 1955036 SGTC_2234 tolnaftate 200 µM 0.475300924785896 0.303573537639241 no 1020 0.317286250016871 363 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_3103 9120822 49.47 µM 0.475161062774107 0.303621701368382 no 1021 0.317336088902932 373 17141819 SGTC_425 3825-7017 13.1 µM 0.474710147880572 0.303777004374788 no 1022 0.317496791938335 380 3397440 SGTC_262 fenpropimorph 62.5 µM 0.472135000146175 0.304664608805702 no 1023 0.318415215765698 362 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2930 9013230 14.89 µM 0.47132972593081 0.304942408041048 no 1024 0.318702645547799 357 2995857 SGTC_536 3852-0578 10.6 µM 0.470030827376282 0.305390732144794 no 1025 0.319166496542817 355 2869208 SGTC_3047 9092122 49.47 µM 0.469041873730698 0.305732272425634 no 1026 0.319519852774618 351 17173831 SGTC_3296 9122258 64.045 µM 0.468809552203858 0.305812530405313 no 1027 0.319602885773581 347 4730474 SGTC_1534 6-azauridine 81.6 µM 0.468102295034623 0.306056917436293 no 1028 0.319855719059161 340 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2792 7535235 81.82 µM 0.467470348229236 0.306275354630662 no 1029 0.320081700901939 327 1281891 SGTC_2910 7948405 25.97 µM 0.467314039007217 0.306329394723999 no 1030 0.320137606804857 362 2971328 SGTC_74 000s-0487 160.283 µM 0.46502716318342 0.307120507387829 no 1031 0.320956002273343 301 677548 SGTC_2192 5915882 198.485 µM 0.464336821045135 0.307359498339755 no 1032 0.321203223626419 343 2876149 SGTC_833 3852-0053 558 µM 0.463036230091056 0.307809974799903 no 1033 0.321669199022532 351 3123681 SGTC_198 3454-2873 16.191 µM 0.461731988844921 0.308262006682966 no 1034 0.322136764131153 355 710957 SGTC_1342 1486-1464 234 µM 0.460217537767192 0.308787259399004 no 1035 0.322680041964494 353 3253938 SGTC_1758 st042942 75.2445 µM 0.459215124260995 0.309135138929339 no 1036 0.323039845359983 352 669317 SGTC_997 3996-0078 137 µM 0.455359731896378 0.31047471525435 no 1037 0.324425230061047 351 735687 SGTC_866 0495-0101 262 µM 0.454778988938321 0.310676716043387 no 1038 0.324634123788223 355 635694 SGTC_1831 st055328 12 µM 0.454129309698531 0.310902762709678 no 1039 0.324867879342563 343 1103068 SGTC_1597 7-benzyloxygramine 47.5 µM 0.452900206291428 0.311330606986853 no 1040 0.325310301194997 352 260807 SGTC_135 0933-0004 26.348 µM 0.452373014130611 0.311514197911351 no 1041 0.325500142145836 354 21230617 YGL099W LSG1 SGTC_1398 3558-0053 112 µM 0.449652755854913 0.312462252668148 no 1042 0.326480420943929 368 4532369 SGTC_2974 9094440 9.66 µM 0.448771816344959 0.312769541253268 no 1043 0.326798135883688 337 25236134 SGTC_467 ro 31-8220 72.8 µM 0.447394984722117 0.313250067153198 no 1044 0.327294948164303 367 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.445118352758415 0.314045326767941 no 1045 0.328117113248741 348 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2582 agaric acid 100 µM 0.444782379446425 0.314162760253184 no 1046 0.328238514693222 329 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_449 xestospongin c 11.1929 µM 0.444588643113479 0.314230485891065 no 1047 0.328308528116843 385 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1950 st077106 7.18 µM 0.443715061935754 0.314535946865147 no 1048 0.328624302211099 332 13831864 SGTC_784 4579-0127 173 µM 0.442764366287219 0.314868516401407 no 1049 0.328968090040705 387 1948547 SGTC_3216 9129716 49.47 µM 0.442573017767777 0.31493547153822 no 1050 0.329037302448817 327 8056934 SGTC_1400 3771-8998 51.5 µM 0.4382564579432 0.316447500288956 no 1051 0.330600192991116 370 670767 SGTC_1410 3909-8106 77.9 µM 0.43747744427973 0.316720705652334 no 1052 0.330882565258757 382 1039210 SGTC_2184 6075246 200 µM 0.437008266696675 0.316885297666875 no 1053 0.331052676424713 355 2267320 SGTC_500 h-89 112 µM 0.436922548155886 0.316915372473537 no 1054 0.331083759430446 380 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_803 4488-1585 147 µM 0.436659752256385 0.31700758335394 no 1055 0.331179060963142 372 747204 SGTC_1827 berberine 7.24 µM 0.436268084204106 0.317145034504626 no 1056 0.331321117590356 364 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_770 0389-1121 67.2 µM 0.435169180086543 0.317530816224621 no 1057 0.331719815801742 346 6753108 SGTC_180 1486-1293 102.781 µM 0.434267464976827 0.317847520801697 no 1058 0.332047113469779 349 4140536 SGTC_1777 st045864 34.765 µM 0.434263021340073 0.317849081846713 no 1059 0.332048726704725 398 4691462 SGTC_709 3807-1509 243 µM 0.433483484817745 0.318122982300158 no 1060 0.332331780788267 386 1886677 YPL242C IQG1 SGTC_2706 st078239 82.5 µM 0.433406290764225 0.318150110866908 no 1061 0.332359815590025 357 15434492 SGTC_1704 st028805 70.8 µM 0.432026631394371 0.318635133633778 no 1062 0.332861028784646 357 2876101 SGTC_800 3448-7362 155 µM 0.431895645352961 0.3186811982829 no 1063 0.332908629939238 363 15991913 SGTC_2161 5662504 8.5105 µM 0.431554261899113 0.318801267822442 no 1064 0.333032703495904 331 2859334 SGTC_672 1441-0018 53.7 µM 0.430447170306081 0.319190778902649 no 1065 0.333435194314527 351 251141 SGTC_1888 azatryptophan 97.5 µM 0.429084931252834 0.319670333215898 no 1066 0.33393070898572 334 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2649 anisomycin 9.56 µM 0.427371356914917 0.320273997797356 no 1067 0.33455443327039 362 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2146 5545642 200 µM 0.426025352393662 0.320748507338651 no 1068 0.335044686244389 362 825326 SGTC_296 1222-0039 74.9 µM 0.424392177671965 0.321324646979698 no 1069 0.335639912271181 342 5984176 SGTC_2316 5844804 197.44 µM 0.424380935742752 0.321328614319091 no 1070 0.335644010930644 373 776813 SGTC_2581 avocatin a 64 µM 0.423270219608764 0.321720692674478 no 1071 0.336049059756095 375 6710728 A skin care supplement. SGTC_2372 9071633 200 µM 0.423075878945701 0.321789314580484 no 1072 0.33611995025127 357 21321366 SGTC_681 1642-0006 26.6 µM 0.420938087820229 0.322544571829048 no 1073 0.336900145926469 396 4446530 SGTC_3056 9094900 49.47 µM 0.420010896987948 0.322872365831028 no 1074 0.337238746594416 356 25236784 SGTC_3083 9117465 49.47 µM 0.419115548210702 0.323189033220826 no 1075 0.337565844040907 380 16420915 SGTC_347 4534-1311 26.2 µM 0.418658062646266 0.323350886427356 no 1076 0.337733024481682 355 2862016 SGTC_3129 9127257 49.47 µM 0.418016632117434 0.323577873578777 no 1077 0.337967478449153 382 837894 SGTC_904 1141-0088 396 µM 0.414724316387562 0.324743978434207 no 1078 0.339171864690592 365 1378119 SGTC_1712 st032288 53.4 µM 0.414073502975475 0.324974693879985 no 1079 0.339410138675288 363 2883011 SGTC_1248 0469-0687 58.6 µM 0.409684366433938 0.326532406398149 no 1080 0.341018749865598 368 4017482 SGTC_3318 9139014 38.6185 µM 0.409090166109295 0.326743522596541 no 1081 0.341236746363293 378 16643984 SGTC_2165 5727197 32.143 µM 0.408942619002659 0.32679595389638 no 1082 0.341290885739007 386 1361712 SGTC_2926 9010726 65.15 µM 0.40882760493894 0.326836826855659 no 1083 0.341333090049619 361 2994293 SGTC_1297 1068-0111 14.1 µM 0.408314107583496 0.327019335589578 no 1084 0.341521541659919 364 767057 SGTC_527 4476-4215 268 µM 0.406425997306524 0.327690768801764 no 1085 0.342214810539458 351 4418754 SGTC_521 r062-0005 13.8 µM 0.40490460958171 0.328232197120978 no 1086 0.342773814965661 356 2832033 SGTC_2776 terbinafine 19.92 µM 0.40412810071369 0.32850867872655 no 1087 0.343059260936736 348 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.404114287064492 0.328513598027102 no 1088 0.343064339668983 410 1273210 SGTC_2621 lithochol-11-enic acid 100 µM 0.403240045278418 0.328824992425655 no 1089 0.343385821424286 401 6708711 SGTC_448 monastrol 171 µM 0.400957400142034 0.329638603057233 no 1090 0.344225744062663 382 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_3086 9117350 49.47 µM 0.399971689937454 0.329990192657982 no 1091 0.344588684199411 359 2679265 SGTC_1916 st067606 49.2 µM 0.399888202337144 0.330019978469416 no 1092 0.34461943105117 380 19590279 SGTC_911 3456-4043 236 µM 0.398714420275469 0.330438861856178 no 1093 0.345051820634741 371 914281 SGTC_906 1165-0455 526 µM 0.397614933503091 0.330831424552744 no 1094 0.345457025447095 377 3252859 SGTC_1727 st034309 9.9045 µM 0.397460746137158 0.330886490770924 no 1095 0.345513863828341 403 870305 SGTC_199 4063-0024 41.6 µM 0.396808598882589 0.331119438008471 no 1096 0.345754304618581 387 306215 SGTC_440 fluspirilene 35.1 µM 0.396025095379814 0.331399392203292 no 1097 0.346043257553343 375 3396 An atypical antipsychotic. SGTC_3250 9135583 49.47 µM 0.392740251902568 0.332574126189135 no 1098 0.347255668922532 355 7699353 SGTC_1123 mangostin 811.285 nM 0.389944393269538 0.333575285663295 no 1099 0.348288833034615 374 5281650 An antioxidant. SGTC_1352 1496-0991 99 µM 0.389732889017086 0.333651070854683 no 1100 0.348367036932125 415 3000039 SGTC_2673 kobusone 100 µM 0.389683660743629 0.333668711067929 no 1101 0.34838524005779 390 6710676 An epoxy ketone and protein crosslinker. SGTC_2856 9022925 19.48 µM 0.389559350439564 0.333713257436923 no 1102 0.348431207800233 362 4944862 SGTC_84 0443-0269 128.823 µM 0.388713452572728 0.334016445601368 no 1103 0.348744064888587 394 6150058 SGTC_2467 5474540 200 µM 0.388557907389309 0.33407220817371 no 1104 0.348801604803426 352 5413519 SGTC_2249 haloperidol 116.36 µM 0.38842338500555 0.334120437077226 no 1105 0.348851370682112 366 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2352 9027995 87.8 µM 0.386528179761659 0.334800196014088 no 1106 0.349552768353964 380 2997347 SGTC_3302 9125395 16.351 µM 0.385419313708966 0.335198167660546 no 1107 0.34996338775528 381 17599668 SGTC_1323 1348-1351 11.2 µM 0.385032530766139 0.335337027481702 no 1108 0.350106656989996 402 6989654 SGTC_2351 9026858 72.31 µM 0.384290224970403 0.335603587383034 no 1109 0.350381676087665 395 1409300 SGTC_1418 3966-3099 2.4 µM 0.383433318912911 0.335911402814702 no 1110 0.350699251339993 394 740335 SGTC_858 0438-0351 2.77 µM 0.382361742878429 0.336296486316294 no 1111 0.351096531585434 367 2799119 SGTC_2565 isoliquiritigenin 100 µM 0.382163693525911 0.336367676513639 no 1112 0.351169975006422 336 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_3259 9138485 49.47 µM 0.381872029264528 0.336472527913687 no 1113 0.351278144133265 358 17646153 SGTC_3106 9121286 49.47 µM 0.381814083769039 0.336493360455989 no 1114 0.351299635735015 342 15943471 SGTC_2408 sulbentine 18.36 µM 0.38083700267888 0.336844715816634 no 1115 0.351662100219471 360 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1036 k216-0215 33.5 µM 0.380313717221433 0.337032946248844 no 1116 0.351856277154111 362 622330 SGTC_2693 st077581 40.7 µM 0.38006768984142 0.337121458593399 no 1117 0.351947584551731 406 25238761 SGTC_2309 7664088 163.95 µM 0.379413949650934 0.337356696046378 no 1118 0.352190246645923 405 704922 SGTC_1742 st038235 28.8875 µM 0.379284455676717 0.337403299831281 no 1119 0.352238320713992 419 564103 YBR002C RER2 SGTC_2095 5432005 200 µM 0.37751896617531 0.338038933129534 no 1120 0.352893986178957 402 783734 SGTC_244 nsc-207895 1.295 µM 0.373378746583757 0.339531355633586 no 1121 0.354433287705335 377 42640 SGTC_705 1124-0212 310 µM 0.371508115397058 0.340206488900654 no 1122 0.355129556282385 422 9554485 SGTC_1133 3473-0247 50 µM 0.371272302432172 0.340291633058593 no 1123 0.355217362743795 368 711311 SGTC_1829 berberine 14.4 µM 0.370837617136124 0.340448604686968 no 1124 0.355379240730071 397 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1054 3429-0080 167 µM 0.370525722700228 0.340561251659843 no 1125 0.355495407147634 401 1162877 SGTC_2834 9001755 58.44 µM 0.369045377743196 0.341096101950186 no 1126 0.356046950878562 408 2989575 SGTC_3320 9137005 35.139 µM 0.368700603854819 0.341220715045703 no 1127 0.356175449300934 393 4908713 SGTC_3316 9136639 10.545 µM 0.367212402518996 0.341758800549669 no 1128 0.356730294361968 401 4903665 SGTC_606 k015-0008 38.6 µM 0.36645128979952 0.342034118705168 no 1129 0.357014176774296 388 1970475 SGTC_3003 9075612 71.4286 µM 0.365409005256907 0.342411281735706 no 1130 0.357403060055283 409 6501993 SGTC_79 0052-0007 94.094 µM 0.365165572103072 0.342499393571794 no 1131 0.35749390793403 407 2801472 SGTC_1575 cyproterone acetate 48 µM 0.363891552598592 0.342960670971807 no 1132 0.357969496449668 405 9880 An androgen receptor antagonist and liver toxin. SGTC_1895 st058434 18.3 µM 0.363457101946505 0.343118023761801 no 1133 0.3581317263255 408 5393175 SGTC_2341 7987486 176.74 µM 0.361073353489119 0.343981872273763 no 1134 0.359022306136174 422 1258686 SGTC_540 1187-0821 17.3 µM 0.36015803423123 0.344313792355791 no 1135 0.359364477788057 424 847520 SGTC_826 1683-5028 118 µM 0.359522910591342 0.344544176265018 no 1136 0.359601970885058 390 722377 SGTC_2745 rifampicin 24.3 µM 0.358122473506262 0.345052372663083 no 1137 0.360125830744083 395 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2644 guaiazulene 100 µM 0.35794405405331 0.345117138350352 no 1138 0.3601925907917 398 3515 A coloring agent. SGTC_2873 9040596 71.43 µM 0.357624888539533 0.345233005720846 no 1139 0.3603120250905 421 6463863 SGTC_895 0964-0006 13.7 µM 0.356449145962275 0.345659963272493 no 1140 0.360752114939485 409 6738897 SGTC_2373 9071805 200 µM 0.356307082817572 0.345711565197621 no 1141 0.360805302812824 392 10149009 SGTC_1571 st070080 73.4 µM 0.355442191015141 0.346025783669924 no 1142 0.361129172902044 360 4315245 SGTC_1354 1498-1681 81 µM 0.354881843432938 0.346229416698887 no 1143 0.361339055580339 379 5754243 SGTC_493 zm226600 134 µM 0.354150829565883 0.346495137517306 no 1144 0.361612925421278 409 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.35368879600084 0.346663123975674 no 1145 0.361786060030879 388 229346 A bile salt which induces apoptosis. SGTC_1168 k815-0004 80.5 µM 0.353385692776072 0.346773342821345 no 1146 0.361899655156279 400 642433 SGTC_1990 st072050 59.8 µM 0.352662912766926 0.347036223024025 no 1147 0.362170583201379 370 17233948 SGTC_1734 st037168 69.4 µM 0.352326163844286 0.347158726141959 no 1148 0.362296834313738 366 708907 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.35231463820537 0.347162919242004 no 1149 0.362301155675863 384 88881 An O-methylated flavonoid and antioxidant. SGTC_1956 st077085 54 µM 0.352039466627354 0.347263033950373 no 1150 0.362404332262029 423 24208685 SGTC_2557 derrustone 83.84 µM 0.349969448725961 0.348016502536954 no 1151 0.363180812956341 396 629853 An antioxidant. SGTC_129 0088-0017 176.636 µM 0.349082511178007 0.348339524054393 no 1152 0.363513682883437 403 182446 SGTC_1661 st013063 9.66 µM 0.34905532514959 0.348349426910267 no 1153 0.363523887498674 402 721395 SGTC_2156 5649887 115 µM 0.34904892477392 0.348351758343367 no 1154 0.363526289973686 398 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2519 cryptotanshinone 88.04 µM 0.348846112909562 0.348425638582289 no 1155 0.363602421164923 374 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1070 indatraline 8.81 µM 0.348040339930802 0.348719222083559 no 1156 0.363904944114441 415 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1806 st050005 60.3 µM 0.347928497629401 0.348759979007651 no 1157 0.363946941389825 394 5194765 SGTC_1671 st016596 74.5 µM 0.347567165258614 0.348891665584954 no 1158 0.364082634448607 390 2829167 SGTC_1995 st072814 61.1 µM 0.346618124324584 0.349237627571915 no 1159 0.364439113940977 379 5769371 SGTC_1405 3909-7894 12 µM 0.346234794635152 0.349377401560234 no 1160 0.364583133806101 392 7104060 SGTC_1767 st044992 70.3 µM 0.344772723558085 0.349910705789527 no 1161 0.365132620313949 405 9600693 SGTC_192 3455-0609 60.9 µM 0.343478781868053 0.350382930374379 no 1162 0.365619150307149 374 3769639 SGTC_2797 7859098 81.82 µM 0.343270318295956 0.350459030904338 no 1163 0.365697554133855 374 972681 SGTC_1997 st073024 93.8 µM 0.342767066398028 0.350642769921812 no 1164 0.365886851923501 410 686268 SGTC_775 4577-0580 57.3 µM 0.342750886062604 0.350648677998566 no 1165 0.365892938685514 400 2006902 SGTC_722 3534-0461 190 µM 0.341629447770043 0.351058247161109 no 1166 0.366314886521746 373 658262 SGTC_831 k061-1017 217 µM 0.340357744433751 0.351522905199632 no 1167 0.366793568085004 423 1240153 SGTC_1515 3460-0031 42.1 µM 0.339525021492016 0.351827287819228 no 1168 0.367107125458598 404 2876596 SGTC_1509 1326-1131 80 µM 0.338987155313417 0.352023942874095 no 1169 0.367309703236241 391 768313 SGTC_1695 st026914 34.495 µM 0.336747847984077 0.352843105129224 no 1170 0.368153495158362 389 3289191 SGTC_2456 5770359 74.46 µM 0.335139379978551 0.353431921230795 no 1171 0.368759973957006 433 3118787 SGTC_2719 novobiocin 32.65 µM 0.334270807059095 0.353750028018467 no 1172 0.369087608644958 409 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2402 5553605 200 µM 0.334250290155358 0.353757543380167 no 1173 0.369095348984294 388 6758546 SGTC_3215 9129942 49.47 µM 0.331615572538654 0.354723115651383 no 1174 0.370089779602271 429 17682944 SGTC_2657 nystatin 74.44 µM 0.330693210821769 0.355061364179279 no 1175 0.370438115516144 389 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1035 k081-0041 55.2 µM 0.329913212032599 0.355347494544846 no 1176 0.370732770081641 429 731709 SGTC_2025 5147754 141 µM 0.329346766923531 0.355555337213277 no 1177 0.37094679954201 413 315777 YLR208W SEC13 SGTC_1638 st008370 60.6 µM 0.329226514692136 0.355599466250153 no 1178 0.370992241600991 361 24207134 SGTC_89 0302-0250 142.109 µM 0.328130505796511 0.356001758471756 no 1179 0.371406494736137 403 4203518 YLR208W SEC13 SGTC_2469 5655019 90.81 µM 0.327599762690703 0.356196626436201 no 1180 0.371607150695019 425 2788239 SGTC_2859 9028643 45.46 µM 0.327324415132679 0.356297738016681 no 1181 0.371711264012922 401 17151580 SGTC_2656 pseudo-anisatin 100 µM 0.326978261446157 0.356424864959677 no 1182 0.371842163574078 418 6708809 A neurotoxin. SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.326849423147989 0.356472185644918 no 1183 0.371890888135854 408 616764 SGTC_3301 9125354 19.7965 µM 0.325042637866267 0.357136027615992 no 1184 0.372574400944328 380 41905162 SGTC_380 3970-0968 6 µM 0.324942641671568 0.357172780480989 no 1185 0.372612241578022 407 2891601 SGTC_426 0988-0037 14.6 µM 0.323931026580547 0.357544666623886 no 1186 0.372995126788086 433 5383008 SGTC_1337 1486-1011 40.3 µM 0.323262078867414 0.357790657013149 no 1187 0.373248385105669 388 X1337 SGTC_76 0433-0009 400.328 µM 0.322923546058122 0.357915167314293 no 1188 0.373376571831052 435 2841569 SGTC_1122 capsaicin 818.572 nM 0.322753630511215 0.357977666914203 no 1189 0.373440916276944 425 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2541 muurolladie-3-one 83.07 µM 0.32149005019655 0.358442565737032 no 1190 0.373919525600984 433 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1486 3970-0793 4.53 µM 0.321113046487528 0.358581314328041 no 1191 0.374062361890325 428 2844330 SGTC_499 genistein 192 µM 0.319763032153618 0.359078312803644 no 1192 0.374573986728859 419 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_3262 9137218 49.47 µM 0.318306928798908 0.359614634685392 no 1193 0.375126064507494 388 17650664 SGTC_2983 9022671 12.99 µM 0.317981196624084 0.359734648471445 no 1194 0.375249600077963 434 6405161 SGTC_2622 2-methoxyxanthone 59.94 µM 0.315890884242841 0.360505138484007 no 1195 0.376042665624522 389 71034 A hepatoprotective. SGTC_3353 9151644 39.2805 µM 0.315702344535204 0.360574662208941 no 1196 0.376114223484287 443 4909158 SGTC_1425 4048-4433 7.33 µM 0.314826813223505 0.360897573388597 no 1197 0.376446576091796 446 23734946 SGTC_1379 2144-0755 36.5 µM 0.314808162529015 0.360904453168865 no 1198 0.376453656912538 438 5392327 SGTC_2917 7979103 53.79 µM 0.314782554117548 0.360913899552297 no 1199 0.376463379329813 405 2980565 SGTC_67 0335-0847 266 µM 0.31364851557123 0.3613323065868 no 1200 0.376894003705724 423 4552207 YOR254C SEC63 SGTC_1722 st034304 3.6505 µM 0.312786453282888 0.361650478170279 no 1201 0.377221454032925 411 4036148 YLR033W RSC58 SGTC_177 1327-0068 8.361 µM 0.310938167952564 0.362332969054613 no 1202 0.377923813916773 376 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2895 9054447 58.44 µM 0.31079049592848 0.362387516785701 no 1203 0.377979947648519 394 2697450 SGTC_2532 xanthone 78.9 µM 0.309205520211227 0.362973157694886 no 1204 0.378582597502975 420 7020 An insecticide. SGTC_2232 chlorophetanol 41.5365 µM 0.309056582868778 0.363028205825935 no 1205 0.378639242641027 419 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1253 0550-0034 176 µM 0.308531245778626 0.363222396139938 no 1206 0.378839064197102 387 5969915 SGTC_2543 pimpinellin 60.67 µM 0.307261414039373 0.363691933269446 no 1207 0.379322201562144 424 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1176 0848-0131 83.3 µM 0.306189051268953 0.364088613164417 no 1208 0.379730354082455 432 6769040 SGTC_1629 st005085 44.9 µM 0.305907950486945 0.364192619840232 no 1209 0.379837366179143 432 24207091 SGTC_1184 1269-1718 139 µM 0.305776629363443 0.364241211797704 no 1210 0.379887361897107 388 5403821 SGTC_1467 k284-1082 293 µM 0.305525450565172 0.364334160040758 no 1211 0.379982994635624 411 3334705 SGTC_679 0422-0091 41.4 µM 0.304803758480586 0.364601265222206 no 1212 0.380257809404081 436 627384 YHR062C RPP1 SGTC_2945 9067681 61.76 µM 0.304374689363461 0.364760099002194 no 1213 0.380421224273811 445 16456930 SGTC_2596 sinensetin 100 µM 0.304070990375868 0.364872537015966 no 1214 0.380536903692546 393 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_863 0466-0191 129 µM 0.303211293467741 0.365190884277908 no 1215 0.380864421478555 442 765160 YPR165W RHO1 SGTC_2108 5365811 200 µM 0.299563752072489 0.366542606344579 no 1216 0.382254968337733 377 780283 SGTC_890 0929-0006 47.2 µM 0.29912002382907 0.366707158512052 no 1217 0.382424234260721 397 1378169 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.298415167714171 0.3669685976905 no 1218 0.382693156993457 447 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2106 5357045 167.29 µM 0.298286097006878 0.367016478177153 no 1219 0.382742407285086 409 668842 SGTC_3287 9117173 37.0625 µM 0.297140489005352 0.367441547206281 no 1220 0.383179626889133 397 2789709 SGTC_3307 9126885 69.2785 µM 0.296766769895519 0.367580247976466 no 1221 0.383322288462344 391 24824909 SGTC_1506 4226-2149 212 µM 0.296118386831385 0.367820927516179 no 1222 0.383569836342811 410 991114 SGTC_2343 7990716 14.84 µM 0.292373266094839 0.369212128029654 no 1223 0.385000623118317 412 6456862 SGTC_1662 st014054 52 µM 0.292106662144047 0.369311229026758 no 1224 0.385102536534575 429 2838777 SGTC_961 1252-1571 372 µM 0.291303031490694 0.369610004052068 no 1225 0.385409784571915 437 6813498 SGTC_841 0251-0215 91.2 µM 0.291195130759673 0.369650125550045 no 1226 0.385451043193537 430 3888614 SGTC_940 3232-1287 54.8 µM 0.291102488046362 0.369684574682961 no 1227 0.385486468553756 435 1585493 YIL048W NEO1 SGTC_628 1636-0253 16 µM 0.28956296152161 0.370257199549146 no 1228 0.38607530297606 418 4456143 SGTC_741 4582-0002 126 µM 0.287626761392052 0.370977774920309 no 1229 0.386816228758605 415 2912688 SGTC_2340 7987427 183.45 µM 0.287485332203255 0.371030426913356 no 1230 0.386870365678187 398 2239331 SGTC_2867 9039098 71.43 µM 0.286736442994392 0.371309267498169 no 1231 0.387157065619531 416 6463460 SGTC_1170 0310-0127 64.8 µM 0.286555745899963 0.371376558178619 no 1232 0.387226251762175 442 774975 SGTC_522 1273-0010 11.6 µM 0.28610671609924 0.371543791616374 no 1233 0.387398193885694 438 5705015 SGTC_3018 9082602 49.47 µM 0.285161749728061 0.371895807289547 no 1234 0.387760111758695 422 17332089 SGTC_665 3914-0008 307 µM 0.284223904697824 0.372245276058236 no 1235 0.388119398629558 408 1069549 SGTC_2801 7907800 81.82 µM 0.283991008445525 0.372332076406605 no 1236 0.38820863565408 445 6620925 SGTC_1640 st009078 66.4 µM 0.283923899026629 0.372357089266546 no 1237 0.388234350537714 430 690618 SGTC_384 k007-0144 5.16 µM 0.283870906675148 0.372376840827815 no 1238 0.388254656411444 415 6824886 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.283739826709746 0.372425699018006 no 1239 0.388304885598989 411 390807 SGTC_2887 9044784 58.44 µM 0.282985933552683 0.37270674179673 no 1240 0.388593809934952 453 6465546 SGTC_44 0929-0055 61.211 µM 0.281643127038451 0.373207492557613 no 1241 0.389108583830748 399 1379590 SGTC_1236 0330-0013 258 µM 0.278723144536535 0.374297132081097 no 1242 0.390228649669747 413 4617066 SGTC_94 0334-0113 514.748 µM 0.278271769369514 0.374465660043857 no 1243 0.390401872688811 450 6795178 SGTC_2634 4'-methoxyflavone 100 µM 0.276591256324863 0.375093316466117 no 1244 0.391046989656441 410 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1961 st076550 68.7 µM 0.27633776658066 0.375188021354721 no 1245 0.391144325618112 401 1579337 SGTC_1351 1496-0003 46.5 µM 0.274871402123812 0.375736009086359 no 1246 0.39170751947564 430 3891978 SGTC_2800 7887935 81.82 µM 0.274369472011333 0.375923640538765 no 1247 0.391900350475459 411 2961002 SGTC_2275 7947463 200 µM 0.27353068161703 0.376237262521631 no 1248 0.392222655366661 429 1225414 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.27228476780125 0.376703257930354 no 1249 0.39270153372792 449 1241132 A phosphatase inhibitor. SGTC_1942 st076330 65.2 µM 0.271093055212317 0.377149149220057 no 1250 0.393159731396392 437 24208414 SGTC_442 cape 100 µM 0.270577609734044 0.377342059145249 no 1251 0.393357959241305 434 5281787 SGTC_1930 st074634 34.3 µM 0.269533287837898 0.377732999431035 no 1252 0.39375966484954 402 684253 YOR116C RPO31 SGTC_3330 9141424 71.43 µM 0.268990254423333 0.377936332682621 no 1253 0.393968591108067 401 27261020 SGTC_2211 7117706 200 µM 0.268286544263751 0.378199879987117 no 1254 0.394239381407659 443 822771 SGTC_2524 avocatin b 10.57 µM 0.268161501066895 0.378246715993388 no 1255 0.394287503850502 448 6710748 SGTC_410 α-linolenic acid 100 µM 0.266404036827743 0.378905178344001 no 1256 0.394964028297156 448 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2107 5363541 170.161 µM 0.265391238587665 0.379284799378326 no 1257 0.395354042425081 456 244052 SGTC_298 1391-0729 10 µM 0.264800106281876 0.379506423756578 no 1258 0.395581727507219 423 3237558 SGTC_3351 9150312 21.596 µM 0.263267998572664 0.380081018086557 no 1259 0.396172011662153 446 4904905 SGTC_637 1181-0519 7.26 µM 0.26268718406847 0.380298913259567 no 1260 0.396395847805873 451 6252091 YGR060W ERG25 SGTC_2255 7941087 197.44 µM 0.261574294787375 0.380716524760706 no 1261 0.39682483197862 432 935561 SGTC_2670 beta-carotene 100 µM 0.260945676723562 0.380952475047693 no 1262 0.397067199903396 407 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_932 2857-0803 154 µM 0.260771667995158 0.381017796635501 no 1263 0.397134297169755 433 674898 SGTC_3193 9111931 49.47 µM 0.260473723140456 0.38112965079971 no 1264 0.397249190919573 418 17087244 SGTC_1016 4226-1401 38 µM 0.25870840218739 0.381792589325024 no 1265 0.397930118107931 454 2901613 SGTC_2843 9000894 45.46 µM 0.258665309751597 0.381808776355937 no 1266 0.397946743804758 398 2242070 SGTC_2387 9077560 195.08 µM 0.258290163726455 0.381949703093822 no 1267 0.398091488496182 409 5303272 SGTC_234 nsc-17383 10.7 µM 0.25717768722389 0.382367706101816 no 1268 0.398520803928842 424 408974 SGTC_502 l-744,832 89.3 µM 0.255005980555879 0.383184099977545 no 1269 0.399359240044776 463 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_92 0063-0024 660.874 µM 0.254177339664607 0.383495741931518 no 1270 0.399679278084095 450 3594437 SGTC_2526 patulin 37.61 µM 0.253543204247714 0.383734283630607 no 1271 0.399924239682052 398 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2605 digitonin 300 nM 0.253383837646538 0.383794239240767 no 1272 0.399985807962097 434 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_703 3875-0075 71.8 µM 0.252608385599027 0.384086013196458 no 1273 0.400285424686797 451 2850814 SGTC_1247 0448-0043 5.84 µM 0.251543131588577 0.384486936025511 no 1274 0.40069710984811 434 3089013 YGL099W LSG1 SGTC_1065 prochlorperazine maleate 2.48 µM 0.250879744383702 0.384736673296166 no 1275 0.400953542661824 466 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1140 3229-1848 2.98 µM 0.250204935230674 0.38499075952564 no 1276 0.401214434427818 443 2849525 SGTC_1623 st003709 20.3 µM 0.247597045680711 0.385973172874198 no 1277 0.402223098386665 404 16192618 SGTC_1680 diphenhydramine 100 µM 0.245593671243855 0.386728357745235 no 1278 0.40299839441661 453 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1912 st060209 90.8 µM 0.245340529767794 0.386823811647021 no 1279 0.403096386132359 467 688787 SGTC_3171 9103192 49.47 µM 0.245031088797149 0.386940504108981 no 1280 0.403216179793414 459 13018434 SGTC_200 k038-0079 37.545 µM 0.243804651284453 0.387403103132249 no 1281 0.403691058907513 440 3436683 SGTC_735 3076-0345 636 µM 0.242666840392117 0.387832416174496 no 1282 0.404131748619754 445 2888990 SGTC_1441 4106-0040 13 µM 0.241444255430296 0.388293868590729 no 1283 0.404605408106614 415 2904180 SGTC_967 1306-0166 352 µM 0.239568743440835 0.389002068141329 no 1284 0.40533229915581 472 4437607 SGTC_463 ikarugamyin 104 µM 0.238063313381245 0.38957079059074 no 1285 0.405915994234115 463 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_3240 9133527 49.47 µM 0.237163864838714 0.389910697883744 no 1286 0.40626483416671 449 17617455 SGTC_716 1683-5115 658 µM 0.236282113049135 0.390243999202037 no 1287 0.406606882874773 457 723597 SGTC_2064 5220758 200 µM 0.236266185211682 0.390250020651783 no 1288 0.406613062249513 419 788518 SGTC_14 0354-0009 295 µM 0.235533594470038 0.390527001831888 no 1289 0.406897303763819 477 1713507 SGTC_1642 st009582 77.7 µM 0.235039125548422 0.390713984268516 no 1290 0.407089182947549 451 6739311 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.234689528966577 0.390846198772259 no 1291 0.407224857728071 432 2346 DNA damaging agent; causes G2/M arrest. SGTC_2434 5670830 169.91 µM 0.234453711165552 0.390935390220338 no 1292 0.407316382440723 444 1549830 SGTC_1382 3002-2117 298 µM 0.234441213044093 0.390940117443255 no 1293 0.407321233305581 461 1497314 SGTC_310 1273-0058 1.06 µM 0.234006058917411 0.391104717866806 no 1294 0.407490137454195 424 2734232 SGTC_1252 0493-0875 34.8 µM 0.233831029975565 0.391170929424338 no 1295 0.40755807941785 422 3960963 SGTC_3169 9102970 49.47 µM 0.233111731668541 0.391443065298238 no 1296 0.407837322640216 439 17027839 SGTC_2441 5730946 39.09 µM 0.232742295709332 0.391582856593152 no 1297 0.407980761857495 411 1774275 SGTC_3104 9120930 49.47 µM 0.232032973457247 0.391851297086295 no 1298 0.408256201736629 450 17014836 SGTC_2100 5377183 190 µM 0.230333537908688 0.392494651702344 no 1299 0.408916300819086 441 2844202 SGTC_865 0488-0499 301 µM 0.229785762115711 0.392702085677527 no 1300 0.409129124450248 450 9634651 SGTC_1489 4065-0444 182 µM 0.229739925259401 0.392719444748337 no 1301 0.409146934350115 474 2877968 SGTC_970 1315-0089 19.5 µM 0.22872738912733 0.393102960977484 no 1302 0.409540402795832 436 6811083 YLR033W RSC58 SGTC_1109 tnp00067 928.257 nM 0.228537775365929 0.393174792139465 no 1303 0.409614096266726 451 676295 SGTC_3344 9148862 3.898 µM 0.228202630963598 0.393301763399885 no 1304 0.409744358093645 442 4905352 SGTC_1871 st057448 67.3 µM 0.226957827682464 0.3937734630846 no 1305 0.410228267549472 469 691747 SGTC_3049 9092223 49.47 µM 0.226004134840598 0.394134956319465 no 1306 0.410599102195167 450 8623917 SGTC_792 4534-1957 155 µM 0.225685819149965 0.394255632854124 no 1307 0.410722894117963 424 1717904 SGTC_2400 5203494 178.7 µM 0.224201840728322 0.394818357123214 no 1308 0.411300125618021 433 6777674 SGTC_1880 MG-132 525 µM 0.223432494145816 0.395110179639229 no 1309 0.411599458401167 466 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2247 cerulenin 830 nM 0.221677756509289 0.395775992881872 no 1310 0.412282373525419 459 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2886 9058944 51.95 µM 0.219560746007304 0.396579670835686 no 1311 0.413106632767036 443 4949929 SGTC_323 4013-0906 34.3 µM 0.219351030271165 0.396659308933683 no 1312 0.413188306626896 454 2910086 SGTC_698 k064-0052 127 µM 0.21572582438815 0.398036634379037 no 1313 0.414600735098871 476 5088751 SGTC_791 1348-1292 225 µM 0.214104254902699 0.398653130355304 no 1314 0.415232878900549 455 5437054 SGTC_93 0109-0045 59.227 µM 0.213977544860873 0.398701314255689 no 1315 0.415282284118919 463 88733 SGTC_2814 7977482 42.97 µM 0.213253778659219 0.398976569679843 no 1316 0.41556451177458 459 6456762 SGTC_3189 9110682 49.47 µM 0.213187825979924 0.399001654634119 no 1317 0.415590231736424 447 17122418 SGTC_160 3453-0671 289.699 µM 0.212765676536325 0.399162228107911 no 1318 0.41575486844735 426 5322268 SGTC_422 cantharidin 155 µM 0.212753874917835 0.399166717348541 no 1319 0.41575947124723 450 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_122 0236-0016 402.397 µM 0.212200370537616 0.399377280927131 no 1320 0.415975358837447 448 6808838 SGTC_656 4090-1979 187 µM 0.211998177503384 0.399454206300939 no 1321 0.41605422807579 454 22330961 SGTC_1433 4060-0023 7.6 µM 0.210445935599175 0.400044894479344 no 1322 0.416659821925882 444 3840627 SGTC_2717 st081029 62.2815 µM 0.210232099262424 0.400126285447736 no 1323 0.416743263873732 481 5292846 SGTC_2881 9058953 51.95 µM 0.209497530517579 0.400405912030222 no 1324 0.417029931489199 443 17122249 SGTC_152 4469-0003 551.229 µM 0.207613080538582 0.401123494411724 no 1325 0.417765545056566 433 697280 SGTC_1786 berberine 21.6 µM 0.207537792614776 0.401152170354868 no 1326 0.417794940434039 471 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1763 st044482 94.5 µM 0.206295172322002 0.401625540986108 no 1327 0.418280174681235 480 88505 SGTC_468 gf-109203x 121 µM 0.205136538530617 0.402067047434748 no 1328 0.418732724896789 461 2396 A protein kinase C inhibitor. SGTC_1211 1056-0033 32.3 µM 0.205076968887457 0.402089750295242 no 1329 0.418755995087615 461 6741922 SGTC_2764 methyldopa 94.69 µM 0.204955758064513 0.402135946528922 no 1330 0.418803345568684 459 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1256 0570-0116 285 µM 0.204148253010849 0.402443740146309 no 1331 0.41911882389798 432 410638 SGTC_1787 fluconazole 80 µM 0.204049240897283 0.402481484382442 no 1332 0.41915750981061 448 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1264 0783-0040 158 µM 0.202680153623501 0.403003484815749 no 1333 0.419692518166446 452 2855798 SGTC_564 3555-0129 330 µM 0.201108692608821 0.403602858651451 no 1334 0.420306792568545 466 563260 SGTC_1516 st013856 110 µM 0.200365481099973 0.403886407287406 no 1335 0.42059737707343 450 5281404 A mutagen and neurotoxin. SGTC_1652 st011932 78 µM 0.200063329577271 0.404001698010541 no 1336 0.420715526149241 447 1551076 SGTC_702 1488-0190 94 µM 0.199727507883562 0.40412984590829 no 1337 0.420846849514498 458 949357 SGTC_2302 7771753 200 µM 0.199568350215729 0.404190583281676 no 1338 0.420909091336327 453 2203047 SGTC_208 k072-0098 12.366 µM 0.199246589096716 0.404313380052901 no 1339 0.421034928560105 460 5948901 SGTC_650 1328-0195 38 µM 0.198074126872434 0.40476091769817 no 1340 0.421493533767144 467 2780821 SGTC_3059 1327-0034 3 µM 0.198044146440536 0.40477236309082 no 1341 0.421505261925586 429 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_667 1498-1044 59 µM 0.197933511554405 0.404814600002306 no 1342 0.421548542207298 481 6739982 SGTC_1201 1889-3372 45.9 µM 0.197818832938461 0.404858381852885 no 1343 0.421593405393346 447 5392199 SGTC_2427 5545055 42.75 µM 0.197110504939135 0.405128832758676 no 1344 0.421870531472287 445 5372858 SGTC_2200 6600604 21.907 µM 0.197033492494874 0.40515824006928 no 1345 0.421900664137393 470 2904777 SGTC_1098 clofazimine 15.1 µM 0.195870927113311 0.405602232269034 no 1346 0.422355596636971 452 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_580 1123-0028 41 µM 0.195485557515656 0.405749434565586 no 1347 0.422506421503786 476 1677248 YPR107C YTH1 SGTC_460 trequinsin 123 µM 0.194868866506923 0.405985024027433 no 1348 0.42274780392401 464 5537 A vasodilator. SGTC_2818 7996756 12.99 µM 0.19477074000596 0.406022513640507 no 1349 0.422786214835053 477 2241621 SGTC_3080 9117754 49.47 µM 0.194477035033609 0.406134729921292 no 1350 0.422901187913746 460 9550191 SGTC_2852 9023854 51.95 µM 0.194459635328169 0.406141378093793 no 1351 0.422907999368907 483 19798528 SGTC_2688 kanamycin b 96.69 µM 0.19445397992277 0.406143538947159 no 1352 0.422910213292975 463 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_627 1391-0720 175 µM 0.193501444862304 0.406507530360795 no 1353 0.423283137301791 484 997839 SGTC_447 ml7 120 µM 0.193042906654413 0.406682780005997 no 1354 0.423462682685857 456 4216 Selective myosin light chain kinase inhibitor. SGTC_360 0957-0399 1.01 µM 0.192894342491613 0.406739564054373 no 1355 0.423520857933063 449 6752301 YPR165W RHO1 SGTC_3255 9139072 49.47 µM 0.190916157018685 0.407495850597471 no 1356 0.424295640764826 450 17646060 SGTC_1594 piperine 70.1 µM 0.190178992263266 0.407777766827661 no 1357 0.424584436220536 476 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1851 st056236 18.9 µM 0.188893697299166 0.408269420363159 no 1358 0.425088066739773 456 5393171 SGTC_2849 9019321 12.99 µM 0.187459727791921 0.408818115617603 no 1359 0.42565009824272 460 16489627 SGTC_685 1278-0033 54.9 µM 0.187192826448262 0.408920262727757 no 1360 0.425754724546228 483 3590572 SGTC_1578 josamycin 24.2 µM 0.187017057307024 0.40898753556876 no 1361 0.425823629548164 434 5282165 A P450 substrate. SGTC_639 0833-0042 114 µM 0.183256153717082 0.410427600840906 no 1362 0.427298518000356 477 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1697 st025554 27.742 µM 0.182062295578977 0.41088498761003 no 1363 0.427766918963425 452 1269519 SGTC_3219 9131112 49.47 µM 0.180982017672639 0.411298964383309 no 1364 0.428190845374252 441 17612988 YMR079W SEC14 SGTC_843 0310-0051 143 µM 0.18048924041892 0.41148783597699 no 1365 0.428384250295206 480 2065037 SGTC_943 3253-1379 105 µM 0.179779238447486 0.411760001488612 no 1366 0.428662941679768 478 668464 SGTC_344 k064-0035 6.43 µM 0.179385686583863 0.411910880275333 no 1367 0.428817434772812 467 5088750 SGTC_2835 9006588 71.43 µM 0.179030217475235 0.412047170199366 no 1368 0.428956987439162 392 2345538 SGTC_2608 thymoquinone 42.66 µM 0.178322339762967 0.412318608207551 no 1369 0.429234917692878 470 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2126 5251174 33.877 µM 0.177562469711925 0.412610029524948 no 1370 0.429533300463359 436 790722 SGTC_3181 9108277 49.47 µM 0.175796593159791 0.413287454918725 no 1371 0.430226873110556 474 17097298 SGTC_3214 9129694 49.47 µM 0.174934216751568 0.413618373648464 no 1372 0.430565661864338 489 17158655 SGTC_750 4073-0104 132 µM 0.174744263665772 0.413691272387171 no 1373 0.430640292732965 463 22330957 SGTC_2544 sphondin 68.51 µM 0.174230378083521 0.413888502358107 no 1374 0.430842206191318 486 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1319 1306-0155 43.7 µM 0.17416315754966 0.41391430329622 no 1375 0.430868619499314 460 3122360 SGTC_1185 1319-0113 81.3 µM 0.170783038710601 0.415212155096156 no 1376 0.432197183138992 464 4672763 SGTC_991 3996-0057 64.7 µM 0.17076162565164 0.41522037995538 no 1377 0.432205602052979 435 715343 SGTC_1832 st054113 55 µM 0.168082870576577 0.416249594603605 no 1378 0.433259042463876 481 1251267 SGTC_748 act1.228 77.9 µM 0.167246838864632 0.41657092748946 no 1379 0.433587915652664 432 4421505 YNR035C ARC35 SGTC_2153 5569715 200 µM 0.166914438446328 0.416698702723154 no 1380 0.433718686144218 482 2054701 SGTC_1119 parthenolide 318.541 nM 0.166272443519817 0.416945511467498 no 1381 0.433971275523602 479 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_678 1218-2179 85.9 µM 0.166224461332371 0.416963959071686 no 1382 0.43399015493605 495 6820081 YOR116C RPO31 SGTC_1772 st048439 82.2 µM 0.166000560273506 0.417050044227012 no 1383 0.434078254627831 483 2927068 YDL195W SEC31 SGTC_2784 7567673 72.73 µM 0.165427267487086 0.417270481127519 no 1384 0.434303846492955 484 3471247 SGTC_314 1671-0008 2.74 µM 0.164979601393018 0.417442631374672 no 1385 0.434480018882213 472 3913060 SGTC_1154 4088-0362 150 µM 0.164250846226319 0.417722908418436 no 1386 0.434766837547201 478 6618304 SGTC_211 3455-0679 143.504 µM 0.164200853887529 0.417742136855152 no 1387 0.434786514463186 446 748649 SGTC_335 4077-0256 27.6 µM 0.164118481732743 0.417773819893969 no 1388 0.43481893638265 480 3121989 SGTC_2617 dihydrotanshinone i 20.83 µM 0.1625683814884 0.418370138713627 no 1389 0.435429141838066 464 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_537 1334-0398 209 µM 0.159942446046397 0.419380755597128 no 1390 0.436463205894336 462 5846986 SGTC_1548 st061468 90.8 µM 0.159410765538249 0.419585443015312 no 1391 0.436672628847511 486 390799 SGTC_446 go6976 132 µM 0.159335624801021 0.419614372601789 no 1392 0.436702227369 488 3501 A protein kinase C inhibitor. SGTC_100 0086-0128 49.5915 µM 0.158625588477972 0.419887761819692 no 1393 0.436981933678381 475 93297 SGTC_2437 5741531 144.16 µM 0.157937369141639 0.420152787625828 no 1394 0.437253075639157 484 2262990 SGTC_1725 st036284 20.55 µM 0.156959524017233 0.420529407428435 no 1395 0.437638373892841 440 707914 SGTC_2433 5607874 27.82 µM 0.156591650840441 0.420671113672472 no 1396 0.437783341514615 489 2252428 SGTC_794 k038-0031 316 µM 0.155884917989206 0.420943378872521 no 1397 0.438061866836537 486 6624242 SGTC_1212 0520-0165 585 µM 0.154919765599227 0.421315259932751 no 1398 0.438442285537567 488 5403258 SGTC_998 3996-0085 177 µM 0.153534439888954 0.421849159808151 no 1399 0.438988416579216 473 715391 SGTC_774 k060-0086 136 µM 0.153317930927474 0.421932614641422 no 1400 0.43907378050585 484 5911235 SGTC_1061 3448-9325 110 µM 0.152875846675036 0.422103029869282 no 1401 0.439248091776091 491 723482 SGTC_1013 4112-3890 241 µM 0.152405437265687 0.422284379933198 no 1402 0.43943358442899 479 705171 SGTC_401 neomycin 50 µM 0.1516713210723 0.422567425926934 no 1403 0.439723088954252 448 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_144 4161-2749 112.381 µM 0.150838266346108 0.422888667108248 no 1404 0.44005164971004 467 797501 YMR168C CEP3 SGTC_657 3534-0529 86.7 µM 0.150569934766228 0.4229921516166 no 1405 0.440157489766687 472 1049549 SGTC_3340 9146634 11.102 µM 0.14950770516092 0.423401862187801 no 1406 0.440576514931099 488 4907387 SGTC_2962 9082311 13.18 µM 0.149187660466623 0.423525322280716 no 1407 0.440702778274536 474 16459453 SGTC_288 1315-0019 35.1 µM 0.148261224419065 0.423882745524456 no 1408 0.44106830776801 490 6811474 SGTC_2411 st077133 39.94 µM 0.147574432236645 0.42414775351325 no 1409 0.441339317126091 493 1403142 YNL221C POP1 SGTC_2365 9042475 200 µM 0.1454352016244 0.424973423669714 no 1410 0.442183636616326 474 6464479 SGTC_2299 7976368 114.88 µM 0.144060612833434 0.425504142106523 no 1411 0.442726303314334 458 2979718 SGTC_311 1315-0136 58 µM 0.143967288793112 0.425540178724248 no 1412 0.442763150129908 478 6759207 SGTC_782 0083-0095 30.5 µM 0.141645691612136 0.426436851470553 no 1413 0.443679937039828 456 3591729 An indicator and reagent. SGTC_2923 7992654 58.14 µM 0.141276948660496 0.426579306546108 no 1414 0.443825579629135 496 2985126 SGTC_2193 5925765 200 µM 0.141146863128491 0.426629564286221 no 1415 0.443876961388717 468 877370 SGTC_1435 4092-0789 56.7 µM 0.139753505263589 0.427167954027812 no 1416 0.444427375048077 494 2248285 SGTC_1298 1079-1278 263 µM 0.136985190754196 0.428238024983446 no 1417 0.445521250411377 489 2840950 SGTC_563 tetrahydrosecaminediol 614 µM 0.136893118858009 0.428273623789832 no 1418 0.445557638993684 468 334274 A psychoactive constituent of the cannabis plant. SGTC_1946 st076057 65.1 µM 0.136517838946555 0.428418728573535 no 1419 0.445705961566066 497 953009 SGTC_2774 tamoxifen 10.92 µM 0.135156515450757 0.428945175569524 no 1420 0.446244063594355 479 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1510 1123-0200 71.5 µM 0.134954969649689 0.429023127532797 no 1421 0.446323738772363 484 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_8 0354-0001 70 µM 0.134717815625656 0.429114855250043 no 1422 0.44641749338439 490 4993152 SGTC_2022 5136654 200 µM 0.134508810765443 0.429195698455011 no 1423 0.446500122210106 489 1713771 SGTC_2716 st080858 38.6235 µM 0.134372566802083 0.429248399300801 no 1424 0.446553986699858 498 5296050 SGTC_2588 indole-3-carbinol 100 µM 0.132244196489937 0.430071842345429 no 1425 0.447395572166643 493 3712 Induces cell cycle arrest. SGTC_2954 9074818 52.69 µM 0.132059325299449 0.43014338138617 no 1426 0.447468683890602 493 16648742 SGTC_2627 acetyl isogambogic acid 100 µM 0.131840689561923 0.430227989150276 no 1427 0.447555150913982 474 6857789 A caspase activator and apoptosis inducer. SGTC_496 calpeptin 138 µM 0.130970156354053 0.430564900249535 no 1428 0.447899457896233 455 73364 A calpain inhibitor. SGTC_195 4234-0266 16.654 µM 0.130409949308518 0.430781736613043 no 1429 0.448121047701467 502 2303354 SGTC_2154 5570129 200 µM 0.130074526016254 0.430911577116571 no 1430 0.448253732082776 509 673366 SGTC_1487 3970-0795 2.82 µM 0.129711154611759 0.431052244606685 no 1431 0.448397478513624 466 3765103 SGTC_1690 st023502 41.2 µM 0.128514934224136 0.431515384349689 no 1432 0.448870740211127 501 24207482 SGTC_615 k087-0205 167 µM 0.128125274264435 0.431666269064972 no 1433 0.449024917458354 496 9642773 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.125430325045668 0.432710083121175 no 1434 0.450091440885668 478 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1025 k007-0731 70 µM 0.123345367672784 0.433517956380894 no 1435 0.450916808441776 500 6256118 SGTC_1775 st081588 35.1725 µM 0.122734803572392 0.43375458874208 no 1436 0.451158551472324 494 1426443 YGL099W LSG1 SGTC_3130 9127414 49.47 µM 0.122657206098566 0.433784664393245 no 1437 0.451189276242784 502 1494646 SGTC_1773 st048542 73.5835 µM 0.122496676440632 0.433846884568334 no 1438 0.45125283899378 493 3237138 SGTC_836 0330-0104 1.35 µM 0.122050278603063 0.434019913867026 no 1439 0.4514295996555 488 46494820 SGTC_2472 5377652 49.4 µM 0.120799286703334 0.43450488098958 no 1440 0.451925007548266 490 1610903 SGTC_400 oxethazaine 37.5 µM 0.120483657713785 0.434627255243147 no 1441 0.452050012296244 482 4621 A local anesthetic. SGTC_1591 genipin 88.4 µM 0.120380672861238 0.434667185423241 no 1442 0.452090800439304 496 442424 A DNA cross-linking agent. SGTC_2323 6148992 148.28 µM 0.120349464973259 0.43467928574779 no 1443 0.452103160723866 463 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2698 st077697 67.5 µM 0.119907286061801 0.43485073962432 no 1444 0.452278296339922 502 3154499 SGTC_2109 5483026 200 µM 0.119031588692106 0.435190325433665 no 1445 0.452625164763383 510 759335 SGTC_1729 st035615 45.989 µM 0.118745304284498 0.43530135375963 no 1446 0.452738571407647 514 17385451 SGTC_796 1234-0020 70.7 µM 0.118309029313695 0.435470562022053 no 1447 0.452911401645024 501 46495034 SGTC_1937 st074714 47.2 µM 0.116952646767336 0.435996707264354 no 1448 0.453448789140159 476 17250970 SGTC_2374 9071832 200 µM 0.115196689191297 0.436678017109052 no 1449 0.454144611425274 501 17381698 SGTC_99 0109-0120 622.8 µM 0.114929575144901 0.436781673614887 no 1450 0.454250471419187 503 759414 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.114112559062503 0.437098752489778 no 1451 0.454574283283456 501 364106 SGTC_3275 9138069 49.47 µM 0.112667477338961 0.437659678565028 no 1452 0.455147093177043 501 17617007 SGTC_2521 angolensin 13.4 µM 0.112520631334473 0.437716685662957 no 1453 0.455205306090134 495 821428 A flavenoid. SGTC_1082 camptothecin 424.86 nM 0.112493363195071 0.437727271571664 no 1454 0.455216115872732 517 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3036 9090181 49.47 µM 0.111585805422197 0.438079624759782 no 1455 0.455575913678983 494 25236586 SGTC_1778 st046819 58.9 µM 0.110275136564478 0.438588569689845 no 1456 0.456095587566633 521 671715 SGTC_3348 9149464 3.537 µM 0.110036004486055 0.438681437884845 no 1457 0.456190410412299 493 1951442 SGTC_1891 st059073 26.2 µM 0.109244555601379 0.438988825253997 no 1458 0.456504260750521 511 688754 SGTC_944 3370-0224 231 µM 0.108674841207116 0.439210116923829 no 1459 0.456730198726278 480 4580514 SGTC_785 1270-0111 65.3 µM 0.108539662514704 0.43926262658343 no 1460 0.45678381010039 511 6741994 SGTC_2836 9010338 19.48 µM 0.108267951790622 0.439368174834411 no 1461 0.456891571956563 503 2994051 SGTC_969 1313-0238 134 µM 0.106930689245231 0.439887708070943 no 1462 0.457421983134457 497 5212874 SGTC_86 0417-1630 471.922 µM 0.106748451359527 0.439958516443294 no 1463 0.4574942717761 477 3634867 SGTC_2536 dehydroabietamide 32.04 µM 0.106633135662931 0.4400033232494 no 1464 0.457540014994935 490 3983547 SGTC_2031 5180455 200 µM 0.106131127426226 0.440198391380396 no 1465 0.457739157247188 513 29949 SGTC_2499 avocadenofuran 51.48 µM 0.106066743577818 0.440223410421486 no 1466 0.457764698522292 475 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2314 7727897 200 µM 0.104409776204094 0.440867376330726 no 1467 0.458422082399115 500 900724 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.101630964494931 0.441947687487389 no 1468 0.45952480029157 488 6708739 YPR165W RHO1 SGTC_2777 climbazole 1.536 µM 0.101621071716137 0.441951534252746 no 1469 0.459528726611643 515 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1848 st056003 16.4 µM 0.101307050340786 0.44207364298453 no 1470 0.459653359814053 506 146492 SGTC_1128 3448-9350 235 µM 0.100945666677691 0.442214175582822 no 1471 0.459796795731029 478 619386 SGTC_1824 st053723 68.6 µM 0.100161254548056 0.442519237823334 no 1472 0.460108152835701 486 675225 SGTC_2900 5328528 85.29 µM 0.0998063752167525 0.442657263578889 no 1473 0.460249023317559 513 795359 SGTC_1619 st003326 88.7 µM 0.0989016859194105 0.44300916230531 no 1474 0.460608165150477 501 2849032 SGTC_2085 5307070 144.047 µM 0.0981827733715697 0.443288831166473 no 1475 0.460893580612434 496 2840351 SGTC_1696 st025591 34.7925 µM 0.0978903688682467 0.44340258944077 no 1476 0.461009673892636 492 2787147 SGTC_1213 1315-0166 115 µM 0.0959915086752406 0.444141443066666 no 1477 0.461763658257766 456 768401 SGTC_1206 3978-0017 132 µM 0.0959520554943928 0.44415679651536 no 1478 0.461779325481175 504 3873677 SGTC_825 1988-2224 89.6 µM 0.0954534561973318 0.444350836721784 no 1479 0.461977328981522 492 1180859 SGTC_1454 4239-0054 42.6 µM 0.0951672004951687 0.444462245066311 no 1480 0.462091010962432 526 1340767 SGTC_1388 3346-4487 254 µM 0.0951254934792563 0.444478477457349 no 1481 0.462107574511058 508 3345614 SGTC_3090 9117696 49.47 µM 0.0937208595263353 0.445025215889158 no 1482 0.462665449851549 513 7923821 SGTC_2606 farnesol 9.78 µM 0.0926435043936101 0.445444635546464 no 1483 0.463093390418933 524 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3278 9139605 49.47 µM 0.0921730323866697 0.445627811799604 no 1484 0.463280281926391 491 7958859 SGTC_2655 perillic acid 100 µM 0.0910462381932684 0.446066571391964 no 1485 0.463727925416457 512 5702197 An apoptosis inducer. SGTC_2987 9018338 71.43 µM 0.0906096754191908 0.446236581268116 no 1486 0.463901371844099 506 5055682 SGTC_1420 4'-methoxyflavone 42 µM 0.088450298064042 0.447077648565101 no 1487 0.464759392919353 509 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2386 9075165 157.42 µM 0.0879012324270827 0.447291545154793 no 1488 0.464977588531354 503 16452277 SGTC_3204 9114183 49.47 µM 0.0864896215411463 0.447841529152956 no 1489 0.46553860298356 489 17027248 SGTC_1632 st005650 90 µM 0.0860304406601396 0.448020454327484 no 1490 0.465721109388924 499 2759605 SGTC_2614 arthonioic acid 13.39 µM 0.0841020172574556 0.448772002006893 no 1491 0.466487660394498 502 6710684 SGTC_612 0302-0167 22.4 µM 0.0839672458443649 0.448824532202398 no 1492 0.466541236901153 495 235821 SGTC_609 0986-0026 86.3 µM 0.0835939761255242 0.448970027167947 no 1493 0.466689628264532 506 2848610 SGTC_1215 3852-0577 11.2 µM 0.081544473088237 0.449769014631779 no 1494 0.4675044791032 482 2884876 SGTC_1656 st012921 11 µM 0.0810935077343598 0.449944848441145 no 1495 0.467683794381026 514 6732821 SGTC_558 k064-0027 21.3 µM 0.0786482837032996 0.450898424631313 no 1496 0.468656190805302 494 5088526 SGTC_157 1348-1695 65.819 µM 0.0780917356479888 0.45111550424722 no 1497 0.468877540558569 487 5380510 SGTC_2446 5162541 200 µM 0.0780637281007844 0.451126428879672 no 1498 0.468888679947925 504 1549321 SGTC_2515 chrysin 20.77 µM 0.0776208450529956 0.451299184892871 no 1499 0.469064830225856 514 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_6 0844-0013 19.835 µM 0.0774230121052058 0.451376356851476 no 1500 0.469143517356436 517 1584900 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.0768240773234844 0.451610004405178 no 1501 0.469381748202483 503 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2735 sertaconazole 140 nM 0.0767624458809507 0.451634048102046 no 1502 0.469406263199053 511 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2088 5278280 127.392 µM 0.076720365564079 0.451650464603483 no 1503 0.469423001456151 490 791502 SGTC_546 peri-Naphthalide 147 µM 0.0726103263006387 0.453254279741966 no 1504 0.471058104606959 495 223824 A penicillin ester. SGTC_3145 9085516 49.47 µM 0.0724999250456173 0.453297371038587 no 1505 0.471102032559293 517 25236195 SGTC_1800 st050079 29.0735 µM 0.0723578460539501 0.453352827448972 no 1506 0.471158565397499 514 3645560 SGTC_1010 4112-3296 15.2 µM 0.0710728032994793 0.45385444777965 no 1507 0.471669906620728 514 704384 SGTC_38 0929-0051 58.268 µM 0.0693092617103727 0.454542971267731 no 1508 0.472371726844685 516 1379719 SGTC_1521 st012942 49.4 µM 0.0681166723426241 0.455008660630226 no 1509 0.47284637928583 511 24207259 SGTC_2082 5219693 150 µM 0.0679990460380871 0.45505459540726 no 1510 0.472893196839856 513 2834649 SGTC_981 1488-1094 54.9 µM 0.0678487710976724 0.455113280824108 no 1511 0.472953009729858 517 3449522 SGTC_2734 clemastine 41.6 µM 0.067521618463787 0.455241043959209 no 1512 0.473083226125944 514 26987 Clemastine is a selective histamine H1 antagonist. SGTC_3248 9135562 49.47 µM 0.0668021861287038 0.455522020612466 no 1513 0.473369591510073 484 17650701 SGTC_859 0439-0102 54.6 µM 0.0664627226104789 0.455654606935041 no 1514 0.473504717554313 496 610143 SGTC_2816 7982706 58.44 µM 0.0659633611682561 0.455849654530605 no 1515 0.473703497724094 517 2981853 SGTC_484 loperamide 105 µM 0.0654889167000547 0.456034979563438 no 1516 0.473892365292605 511 3955 An opioid-receptor agonist. SGTC_1613 st002381 52.1 µM 0.0647826138057766 0.456310889637439 no 1517 0.474173542270695 526 551167 SGTC_2955 9076254 12.21 µM 0.064551025070013 0.456401362024885 no 1518 0.474265739831406 524 16459619 SGTC_2476 5806916 10.51 µM 0.0643570591437981 0.456477138436137 no 1519 0.47434296047374 523 2870194 SGTC_1139 k015-0024 46.9 µM 0.0633354973468186 0.456876256685438 no 1520 0.474749674849086 525 2766652 SGTC_690 glyoxal 20.3 µM 0.0628372192366356 0.457070946853507 no 1521 0.474948063876415 524 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.0623251636220772 0.457271030984398 no 1522 0.475151944877265 519 16486 A toxic proline analog. SGTC_2533 agelasine 13.65 µM 0.0614080774475989 0.457629406578525 no 1523 0.475517109814631 515 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1964 st076914 61 µM 0.061138353302493 0.457734814967033 no 1524 0.475624512374022 522 24208661 SGTC_3223 9129970 49.47 µM 0.0609949776493395 0.457790847485306 no 1525 0.475681604432619 519 17248386 SGTC_3068 9116768 49.47 µM 0.0559530016543815 0.459761823357253 no 1526 0.477689623856827 531 41904888 SGTC_2037 5169046 200 µM 0.0556303326666151 0.459887993176709 no 1527 0.477818149970056 512 5718022 SGTC_383 2324-0395 7.37 µM 0.0555529742994183 0.459918242396325 no 1528 0.477848963842572 533 3146421 SGTC_1014 4130-3005 69.3 µM 0.0555472533259968 0.459920479461307 no 1529 0.477851242662033 503 743608 SGTC_17 0960-0276 49.807 µM 0.0550097552800885 0.460130662290293 no 1530 0.478065345986423 522 6821114 SGTC_189 3970-0742 2.116 µM 0.0528190065536972 0.460987445642031 no 1531 0.478938058799129 530 2891807 SGTC_2339 9000433 200 µM 0.0521790682342455 0.461237754481042 no 1532 0.479193005669297 525 2988954 SGTC_3085 9117376 49.47 µM 0.052078182536972 0.461277216847 no 1533 0.479233198592299 529 16480349 SGTC_3163 9099914 49.47 µM 0.0507955053682382 0.461778980898113 no 1534 0.479744236226039 528 16268368 SGTC_1190 1486-1332 13 µM 0.0504944810504602 0.46189674593592 no 1535 0.479864173640048 529 4150046 SGTC_36 0335-0881 14.2 µM 0.049055466280279 0.462459755164935 no 1536 0.48043754670482 527 23828853 SGTC_1317 1273-0028 910 nM 0.0489949572073069 0.462483430772703 no 1537 0.480461657340345 521 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_3009 9080819 71.4286 µM 0.0475592487555644 0.463045224510474 no 1538 0.481033755018458 521 17027216 SGTC_2950 9072895 21.46 µM 0.0473349389644826 0.463133003777597 no 1539 0.481123141007131 516 17332245 SGTC_918 glabranin 770.725 nM 0.0473288620256506 0.463135381894222 no 1540 0.481125562640843 516 124049 Also referred to as licorice root. SGTC_1257 0669-0121 16 µM 0.0471392048995888 0.463209601957729 no 1541 0.48120114053088 525 4307855 SGTC_274 sirtinol 40.1 µM 0.0440697134734871 0.464410987247389 no 1542 0.482424417233652 534 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_924 2046-0044 21.3 µM 0.0440197928274746 0.464430528677823 no 1543 0.482444313381977 531 3623589 SGTC_1266 0828-0227 32.9 µM 0.042175653682161 0.465152476442301 no 1544 0.483179335416836 522 3913820 SGTC_3060 1327-0027 12.5 µM 0.0421511993446736 0.465162050657614 no 1545 0.483189082618082 530 16000455 YPR107C YTH1 SGTC_2062 5245942 200 µM 0.041059770470566 0.46558938078884 no 1546 0.483624123026412 525 1376160 SGTC_2304 7443016 91.4 µM 0.0403135176091435 0.46588158608382 no 1547 0.483921588523246 541 939854 SGTC_337 1315-0038 354 µM 0.039952279626367 0.466023040267438 no 1548 0.484065585615947 531 1626437 SGTC_1679 SEC14.276 6.7 µM 0.0397137387771545 0.466116450853099 no 1549 0.484160674179124 530 1005053 YMR079W SEC14 SGTC_3019 9081971 49.47 µM 0.0397028642892973 0.466120709255398 no 1550 0.484165009053256 524 16451803 SGTC_3033 9090887 49.47 µM 0.0374597831856875 0.466999172298166 no 1551 0.485059202996684 516 19325384 SGTC_958 1222-0007 33 µM 0.0372164116824621 0.467094494187464 no 1552 0.485156226523473 527 7312461 SGTC_130 0136-0219 337.655 µM 0.0371453371702689 0.467122332465175 no 1553 0.485184561559246 534 234244 SGTC_2428 5615643 7.78 µM 0.0355255997654194 0.467756790271699 no 1554 0.485830316797482 537 2253075 SGTC_2244 6635614 200 µM 0.0354648807678049 0.467780575755901 no 1555 0.485854524917994 539 836499 SGTC_1404 3909-7820 48.3 µM 0.0348741626196571 0.468011984070706 no 1556 0.486090041659849 531 23741373 SGTC_1219 1469-0211 33.1 µM 0.0338877629339835 0.468398420987355 no 1557 0.486483325674398 538 6822282 SGTC_2979 9012552 45.46 µM 0.0338390567637458 0.468417503136772 no 1558 0.486502745487182 535 17100905 SGTC_2170 morpholine 200 µM 0.0336164689131729 0.468504709738132 no 1559 0.486591494698473 531 121171 Reacts with secondary amines. SGTC_2793 7325131 81.82 µM 0.0330789639234737 0.46871530240247 no 1560 0.486805808962823 525 4176441 SGTC_60 0986-0278 202 µM 0.0330394740695767 0.46873077474158 no 1561 0.486821554528579 529 3110598 SGTC_2315 7733312 200 µM 0.032635012960119 0.468889247514538 no 1562 0.486982824194083 523 726316 SGTC_1411 3909-8223 150 µM 0.0304277577596061 0.469754163094593 no 1563 0.487862953804992 531 X1411 SGTC_2662 daunorubicin 22.37 µM 0.0298889854297352 0.469965303501925 no 1564 0.488077795140033 525 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3172 9105863 49.47 µM 0.0293127509533782 0.470191134358605 no 1565 0.488307578741339 538 2348785 SGTC_554 4483-2211 187 µM 0.0289058351128047 0.470350613680693 no 1566 0.488469845910405 530 747107 SGTC_1828 st055811 49 µM 0.0286427779751371 0.470453714126401 no 1567 0.488574747088462 537 5877589 SGTC_663 1486-0733 13.9 µM 0.0266099212675754 0.471250521496879 no 1568 0.48938543001777 531 722445 YPR165W RHO1 SGTC_402 epigallocatechin gallate 10 µM 0.0265380655670952 0.47127868849514 no 1569 0.489414086174826 530 65064 An antioxidant. SGTC_27 0485-0001 32.618 µM 0.0261953262419918 0.471413042203947 no 1570 0.489550771861712 535 2054479 SGTC_1711 st032263 62.8 µM 0.0253157126771438 0.471757865300691 no 1571 0.489901570521961 529 3958979 SGTC_2282 7944268 200 µM 0.0247148821679308 0.471993413004238 no 1572 0.490141192226657 531 2970414 SGTC_62 0180-0423 3.232 µM 0.0244190181868248 0.472109406193711 no 1573 0.490259189264491 538 30102 YGL099W LSG1 SGTC_47 0149-0135 24.25 µM 0.0211248455552166 0.473401040964089 no 1574 0.491573032714207 543 5239155 SGTC_2924 9010168 62.78 µM 0.0187626709634786 0.474327415208593 no 1575 0.492515216416469 535 2993929 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.0185208816287033 0.474422245673 no 1576 0.492611659645596 530 6857784 SGTC_2390 9097792 176.6 µM 0.018357503585676 0.474486323826686 no 1577 0.492676826975064 535 4497149 SGTC_300 r073-0011 5.04 µM 0.0165771923276495 0.475184618336065 no 1578 0.493386959972418 539 2735780 SGTC_874 0599-0792 117 µM 0.0161299986291881 0.475360033943627 no 1579 0.493565340590118 538 765305 SGTC_2727 riluzole 51.77 µM 0.0159233855483975 0.475441081332054 no 1580 0.493647756698415 541 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2295 7971645 200 µM 0.0152244822862096 0.475715245175844 no 1581 0.493926544942204 539 2978226 YKL099C UTP11 SGTC_2909 7941780 10.49 µM 0.0147236634757324 0.475911712076545 no 1582 0.494126320340075 535 1243215 SGTC_245 methotrexate 289.6 µM 0.0139350576428542 0.476221087197313 no 1583 0.494440896243547 541 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1358 1509-0022 2.48 µM 0.0139313020004611 0.47622256059433 no 1584 0.494442394382662 536 3258434 SGTC_1847 st056231 15 µM 0.0129340920321374 0.476613793040249 no 1585 0.494840187694979 539 5393180 SGTC_216 k038-0035 28.382 µM 0.0128718156772691 0.476638226490695 no 1586 0.494865030297939 541 4444231 YPR107C YTH1 SGTC_366 0181-0206 4.31 µM 0.0124051346163387 0.476821326517716 no 1587 0.495051194234243 535 274874 SGTC_1567 st069303 68.4 µM 0.0120769829737627 0.476950078138994 no 1588 0.495182097990355 545 5581319 SGTC_1747 st037496 66.6 µM 0.0119275791661371 0.477008698123811 no 1589 0.495241697193086 542 723305 SGTC_2576 guaiol 23.12 µM 0.0116204532847041 0.477129203404329 no 1590 0.495364214199709 540 227829 SGTC_1006 4099-6547 255 µM 0.0113767719099567 0.477224816803765 no 1591 0.495461422576236 539 3146833 SGTC_925 2064-1272 59.6 µM 0.00984528198115089 0.477825758168633 no 1592 0.496072364206027 530 6815817 SGTC_1780 st038448 24.544 µM 0.00913806079215767 0.478103281806641 no 1593 0.496354491925046 531 728868 YDL195W SEC31 SGTC_2125 5246583 200 µM 0.00845706198823894 0.478370525444816 no 1594 0.496626160622196 544 835267 SGTC_3114 9122766 49.47 µM 0.00811477967238745 0.478504850610945 no 1595 0.496762706821685 545 17176985 SGTC_2414 st077232 92.9 µM 0.00792343679280442 0.478579942216364 no 1596 0.496839039131932 545 729801 SGTC_3327 9140648 26.9345 µM 0.0074810146500861 0.478753571594711 no 1597 0.497015534793692 546 8029710 SGTC_483 fpl-64176 144 µM 0.0074336223616656 0.478772171024582 no 1598 0.497034441055595 545 3423 SGTC_1209 2323-2347 50.3 µM 0.00741679830727306 0.478778773751677 no 1599 0.497041152697198 547 5412760 SGTC_1250 0485-0349 40.2 µM 0.00739991263895666 0.478785400665477 no 1600 0.497047888919365 543 6842794 YDL195W SEC31 SGTC_349 k015-0014 24 µM 0.00727343104454413 0.478835039551824 no 1601 0.497098346417036 542 2196908 SGTC_1080 nisoldipine 24.4 µM 0.00694827373319094 0.47896265208904 no 1602 0.497228062136216 545 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2403 6032726 181.2 µM 0.00586920318633938 0.479386163807759 no 1603 0.497658540139635 544 2881040 SGTC_1982 st072467 71.9 µM 0.00570159131908253 0.479451949920307 no 1604 0.497725406481057 539 3163533 SGTC_55 0767-0285 6.563 µM 0.00494121585775981 0.47975039728133 no 1605 0.498028748099307 545 3116166 SGTC_835 0312-0010 67.2 µM 0.00482910488472236 0.47979440180147 no 1606 0.498073473372842 545 1626196 SGTC_1602 st001878 87.6 µM 0.00378335990163897 0.480204877482124 no 1607 0.498490661373993 543 595405 YLR310C CDC25 SGTC_3354 9151612 71.43 µM 0.00377294703099851 0.480208964846986 no 1608 0.498494815478703 544 27261949 SGTC_1283 0922-0125 16.4 µM 0.00355245499387204 0.480295515090052 no 1609 0.498582778484596 545 3360884 SGTC_1242 0402-0103 60.1 µM 0.00347109438951335 0.480327451988804 no 1610 0.498615236469479 546 432868 SGTC_519 k048-0011 62.8 µM 0.00172771566008568 0.481011819465296 no 1611 0.499310741517586 547 6836379 SGTC_1027 k015-0025 8.67 µM 0.000696107539538065 0.481416806178498 no 1612 0.4997222932932 547 3598955 SGTC_1917 st066507 28.5 µM 0.000472779461597465 0.481504482421557 no 1613 0.49981138829049 541 3156428 SGTC_700 3453-2283 142 µM 0.000276750425108843 0.481581442086875 no 1614 0.499889592555714 548 565664 SGTC_2643 anethole 100 µM 0.000133277386689252 0.481637769060307 no 1615 0.499946830015586 547 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2321 7390090 138.78 µM -0.00145883618730975 0.482262851191262 no 1616 0.499418008771135 550 649046 SGTC_2669 eugenol 100 µM -0.00312487075770733 0.482917002220901 no 1617 0.498753358962831 549 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_332 4112-0506 40.9 µM -0.00467269446354874 0.483524780240488 no 1618 0.498135871398682 551 2790355 SGTC_2782 7736369 71.43 µM -0.0059514678419362 0.484026940238489 no 1619 0.497625721863554 550 2950836 YOL077C BRX1 SGTC_1554 st069299 38.7 µM -0.00662485918699155 0.484291383719546 no 1620 0.497357082901009 555 24207999 SGTC_1180 1193-0155 285 µM -0.00735337385959186 0.484577482129781 no 1621 0.497066454700997 556 2921347 SGTC_3128 9127691 49.47 µM -0.00822714957283432 0.484920637143333 no 1622 0.496717879213851 554 41316314 SGTC_927 2425-1185 123 µM -0.00877304991353915 0.485135032442702 no 1623 0.496500104357205 559 730375 SGTC_1195 1502-0147 41.1 µM -0.0107866466921617 0.485925883216593 no 1624 0.495696834017719 554 817940 SGTC_2001 4023502 57.655 µM -0.0115987870663417 0.486244871480941 no 1625 0.495372857187785 553 108941 YCR052W RSC6 SGTC_900 1112-0045 141 µM -0.0124230607136836 0.486568634387648 no 1626 0.495044043307125 553 56211 YIL048W NEO1 SGTC_1826 st055655 41.6 µM -0.0124437551164282 0.486576762968061 no 1627 0.495035788073014 552 676168 SGTC_2972 9093619 59.92 µM -0.0127748653179284 0.486706820915616 no 1628 0.494903704715461 556 25236256 SGTC_3235 9132602 49.47 µM -0.0128060982182069 0.486719089070211 no 1629 0.494891245610175 564 4912240 SGTC_3088 9117578 49.47 µM -0.0128347327982069 0.486730336626346 no 1630 0.494879823004298 553 678341 SGTC_2480 5767542 37.17 µM -0.0132963170009949 0.486911646628438 no 1631 0.49469569326835 553 2867358 SGTC_1235 benzylparaben 21.5 µM -0.0158613688920136 0.487919245748098 no 1632 0.493672494640532 558 7180 SGTC_2049 5262831 67.185 µM -0.0158964821988261 0.48793303944452 no 1633 0.493658488223743 560 763417 SGTC_2990 9074105 71.4286 µM -0.0167808789517494 0.488280465165536 no 1634 0.493305712068225 555 6502001 SGTC_2841 9004761 38.96 µM -0.0169928051292097 0.488363719408325 no 1635 0.493221177809854 556 2991039 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.0172574474143323 0.488467683647714 no 1636 0.49311561629359 560 23847180 SGTC_2040 5100729 123 µM -0.0180240294809981 0.488768838412838 no 1637 0.49280984188482 555 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1269 0831-0796 3.05 µM -0.0186647712390096 0.489020561240466 no 1638 0.492554265917552 554 927758 SGTC_418 lividomycin a 100 µM -0.020030352094483 0.489557059977669 no 1639 0.492009579974491 559 72394 An antibiotic. SGTC_1892 st058411 7.36 µM -0.0204117339694365 0.489706897726062 no 1640 0.491857461723554 563 3934738 SGTC_1216 1165-0504 9.65 µM -0.0211858061230075 0.490011020525459 no 1641 0.491548718407798 561 6304004 SGTC_2017 5132927 60.65 µM -0.0220115130429323 0.490335436344684 no 1642 0.491219385841699 561 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_756 0508-1999 28.3 µM -0.0225309797587627 0.490539535320593 no 1643 0.491012199997156 563 6753853 SGTC_3091 9116372 49.47 µM -0.0229790229510843 0.490715573916515 no 1644 0.49083350289557 559 17169793 SGTC_2023 5144124 124 µM -0.0231099922013235 0.490767032787101 no 1645 0.490781267595856 557 2830192 SGTC_632 0781-2353 4.65 µM -0.0232026006310449 0.490803419475925 no 1646 0.490744332081731 569 6811515 YHR007C ERG11 SGTC_2221 6807166 181.081 µM -0.0274696627136398 0.492480064794961 no 1647 0.489042568179968 551 674925 SGTC_2711 st079103 59.1 µM -0.028854806159969 0.493024355512484 no 1648 0.488490195029119 562 54693780 SGTC_2250 alverine citrate 130 µM -0.0293666999127092 0.493225506985937 no 1649 0.48828606548199 560 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1392 3455-1037 33.9 µM -0.0297832417264992 0.493389190662608 no 1650 0.488119962001607 560 981132 SGTC_1762 st045503 25.4615 µM -0.0304940687582274 0.493668518793996 no 1651 0.487836511814165 567 4645554 SGTC_1531 st059297 52.4 µM -0.0310842152484475 0.493900426402704 no 1652 0.487601188997072 565 7566702 SGTC_2592 piperlongumine 83.33 µM -0.031410542620223 0.494028662911793 no 1653 0.487471066752899 561 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_742 0kpi-0133 140 µM -0.0326481927961246 0.494515026439118 no 1654 0.486977569000634 566 2728852 SGTC_2167 5876490 200 µM -0.033114441524265 0.494698251913858 no 1655 0.48679166319756 561 686534 SGTC_789 1309-1135 70.6 µM -0.0332966230756924 0.494769845554592 no 1656 0.486719023331754 560 3092424 SGTC_2564 betulinic acid 100 µM -0.0346228630828471 0.495291035808359 no 1657 0.48619023516182 591 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_3285 9112818 20.8695 µM -0.0355311971733745 0.495648000682677 no 1658 0.485828085163691 562 17017947 YPR165W RHO1 SGTC_894 0960-0238 55.9 µM -0.0355668941933679 0.495662029274939 no 1659 0.485813853108744 557 6741907 YDL195W SEC31 SGTC_328 k915-0120 63.5 µM -0.0358438071115909 0.495770853621607 no 1660 0.485703451234595 567 6624543 SGTC_188 3229-0966 278.469 µM -0.0376768826266153 0.496491243766456 no 1661 0.484972653949153 563 5722370 SGTC_1529 apigenin 74 µM -0.0382932838123769 0.496733489250673 no 1662 0.48472692280094 565 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1328 1441-0025 69.2 µM -0.0385320784318235 0.496827335794283 no 1663 0.484631727788792 570 4562601 SGTC_611 3453-1652 23.7 µM -0.0388675583496579 0.496959180060102 no 1664 0.484497990850773 565 1560575 SGTC_1338 1486-1223 76 µM -0.0392392643382534 0.497105261630054 no 1665 0.484349814656856 575 3444526 SGTC_1438 4092-1045 4 µM -0.0396783708808318 0.497277832318738 no 1666 0.484174772815806 558 1351342 SGTC_3199 9111318 49.47 µM -0.0403891538633503 0.497557174038275 no 1667 0.483891438579039 571 8548020 SGTC_3274 9138298 49.47 µM -0.0413778202611362 0.497945727468684 no 1668 0.483497347259294 579 17015756 SGTC_2506 ethyl hematommate 54.16 µM -0.0414850143099809 0.497987855670643 no 1669 0.483454619709017 580 3940691 An allergen. SGTC_334 1502-1024 68.5 µM -0.0416497773170325 0.498052609022003 no 1670 0.48338894554135 565 3296216 SGTC_3158 9100007 49.47 µM -0.0420904947229631 0.498225815194449 no 1671 0.483213278784766 569 19297233 SGTC_2817 7995342 71.43 µM -0.0421454446208918 0.498247411056099 no 1672 0.483191376382391 573 18879975 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.042278029948871 0.498299518442335 no 1673 0.483138529592335 562 4000243 SGTC_2460 5552655 174.22 µM -0.0458418792825645 0.499700155577711 no 1674 0.481718139519555 576 5401989 SGTC_2813 7971799 71.43 µM -0.0459288070132462 0.499734319373885 no 1675 0.481683496861108 576 2234054 SGTC_2181 6316240 54.2555 µM -0.0461284913097183 0.499812798061363 no 1676 0.481603918695915 576 12779990 SGTC_2424 5537928 59.2 µM -0.0462894961388428 0.499876075189172 no 1677 0.481539755601679 568 5382802 SGTC_419 nsc-638432 893 µM -0.0464715664206269 0.499947631335312 no 1678 0.481467198151468 583 368090 SGTC_2692 st077426 47.7 µM -0.0467380642082442 0.499947631335312 no 1679 0.481360996314981 568 25238571 SGTC_3161 9100388 49.47 µM -0.0473545007892655 0.499705363229108 no 1680 0.481115345709709 570 25236368 SGTC_1855 st056195 39.6 µM -0.0475698870212289 0.499620713480615 no 1681 0.481029515762629 559 4028379 SGTC_2105 5350118 200 µM -0.0478632232582934 0.499505428337316 no 1682 0.480912624684358 573 2133313 SGTC_3291 9121177 71.43 µM -0.0483732832615891 0.499304967901006 no 1683 0.480709375619972 569 17015612 SGTC_399 oxolinic acid 75 µM -0.0493484090858183 0.498921730878015 no 1684 0.480320820806727 576 4628 A DNA gyrase inhibitor. SGTC_3023 9089636 49.47 µM -0.0496306075546384 0.498810823410892 no 1685 0.480208377689255 560 17249241 SGTC_2030 5175110 200 µM -0.0496651326383007 0.498797254634756 no 1686 0.480194621138437 585 2831986 SGTC_2603 homopterocarpin 100 µM -0.0499717576604782 0.498676747349275 no 1687 0.480072447157874 574 101795 A weak amylase inhibitor. SGTC_630 4356-0227 183 µM -0.0502560094969999 0.498565033099819 no 1688 0.479959189389568 574 779312 SGTC_2486 5283202 22.39 µM -0.0503814171758012 0.498515746471231 no 1689 0.479909222262005 574 1377751 SGTC_2345 9052315 157.45 µM -0.050659472504558 0.498406467680832 no 1690 0.479798435706793 578 6469265 SGTC_114 0364-0001 490.298 µM -0.0511063367579649 0.498230845387647 no 1691 0.479620393295368 575 4003655 SGTC_1524 corynanthine 62.1 µM -0.0513097845171046 0.498150888416619 no 1692 0.479539335729464 607 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2157 5649910 96.377 µM -0.0517124612289362 0.497992632729096 no 1693 0.479378903950619 579 2858091 SGTC_2051 5263410 176 µM -0.052143499726587 0.497823230947034 no 1694 0.479207176160201 561 227584 SGTC_3131 9127911 49.47 µM -0.0530013120603755 0.497486104628815 no 1695 0.478865431155845 591 45595681 SGTC_2228 7354201 200 µM -0.0543406047617527 0.496959756798082 no 1696 0.478331899702724 580 753451 SGTC_2953 9074162 66.49 µM -0.0546807810804095 0.496826066838448 no 1697 0.47819639046384 570 16451992 SGTC_187 1488-2104 32.728 µM -0.0552247893500479 0.496612271269808 no 1698 0.47797969001095 571 2852859 SGTC_2884 9058502 51.95 µM -0.0579957519663762 0.495523297738533 no 1699 0.476876006136468 594 6471554 SGTC_2089 5281248 129.67 µM -0.0583430969942548 0.495386795180846 no 1700 0.476737669760896 573 2737878 SGTC_1309 pyrazolanthrone 13.4 µM -0.0584114205000192 0.495359944900486 no 1701 0.476710459031013 588 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1463 k081-0032 34.1 µM -0.058949670447765 0.495148420170457 no 1702 0.476496097756405 571 977755 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.0600079368879003 0.494732540237517 no 1703 0.476074656680809 600 15053 SGTC_3058 9093861 49.47 µM -0.0607714141957193 0.494432510731618 no 1704 0.475770628198417 575 17217477 SGTC_2671 danthron 100 µM -0.0608789663297288 0.494390245397653 no 1705 0.475727800403234 567 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1838 st055369 84.5 µM -0.0612548477775859 0.49424253376421 no 1706 0.475578124745265 569 676036 SGTC_61 0978-8327 98.565 µM -0.0623517082136707 0.493811500725729 no 1707 0.475141375673716 603 6150059 YHR072W ERG7 SGTC_3218 9131285 49.47 µM -0.0625517574668898 0.493732888172721 no 1708 0.475061723051464 592 17156417 SGTC_1456 k015-0012 13 µM -0.0627144878502986 0.493668940845742 no 1709 0.474996930234141 596 2989616 SGTC_324 1315-0088 19.6 µM -0.0631838734103788 0.493484489718674 no 1710 0.474810043136532 596 6787421 SGTC_1057 3448-5381 134 µM -0.0640461333382371 0.493145657185809 no 1711 0.474466746546583 589 5497911 SGTC_3295 9122362 53.5725 µM -0.0641548738104023 0.493102927018269 no 1712 0.474423454407076 584 4730473 SGTC_512 prima-1 270 µM -0.0643093991912244 0.49304220555492 no 1713 0.474361934738241 574 322968 A re-activator of the apoptotic function of mutant p53. SGTC_173 1273-0061 2.693 µM -0.0649983215180961 0.492771492320467 no 1714 0.474087668332487 588 2847414 YPL266W DIM1 SGTC_2111 5486399 200 µM -0.0652416546492345 0.49267587492977 no 1715 0.473990798071034 581 689674 SGTC_1898 st060199 18.6 µM -0.0664666582370591 0.492194518102474 no 1716 0.473503150930618 570 688866 SGTC_2912 7964298 10.93 µM -0.0666829367194985 0.492109534104477 no 1717 0.47341705929918 579 2975850 SGTC_2947 9072639 7.68 µM -0.0679930517324005 0.491594748146356 no 1718 0.472895582699988 597 16488146 SGTC_2740 felodipine 17.08 µM -0.0680688166539844 0.491564978113066 no 1719 0.472865426734251 573 3333 L-type calcium channel blocker SGTC_1914 st062367 72.6 µM -0.0688175624173654 0.491270778734042 no 1720 0.472567419220652 600 978205 SGTC_590 k048-0076 22.4 µM -0.0689623151580552 0.491213902605873 no 1721 0.47250980810067 587 6832814 SGTC_849 0386-0493 241 µM -0.0691674324209098 0.491133308405347 no 1722 0.472428173082335 581 726119 SGTC_666 0272-0154 136 µM -0.0692377445660766 0.49110568160303 no 1723 0.472400189681324 576 6870312 SGTC_205 1486-1330 71.903 µM -0.0713954505979955 0.490257904673401 no 1724 0.471541515134348 583 4118834 SGTC_2421 5690543 90.72 µM -0.0716082012542648 0.490174315858806 no 1725 0.471456856588251 575 3397993 SGTC_2104 5389443 200 µM -0.07237703564973 0.489872247767352 no 1726 0.471150929876388 598 2244536 SGTC_1289 0976-0073 69.1 µM -0.0732538828448902 0.48952774952229 no 1727 0.470802044605754 599 3391136 SGTC_682 0kpi-0099 17 µM -0.074013662155156 0.489229251552381 no 1728 0.470499757125327 592 1714895 YML126C ERG13 SGTC_268 camptothecin 39.6153 µM -0.0755247893166236 0.488635586213208 no 1729 0.469898587418049 584 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1985 st071382 65.5 µM -0.0764240582459728 0.488282308953274 no 1730 0.469540864931246 617 6123237 SGTC_811 0416-0114 265 µM -0.0769170829949194 0.488088628360386 no 1731 0.469344753771111 573 6612453 SGTC_1311 1190-0148 100 µM -0.0771324568122931 0.48800402146102 no 1732 0.469259086550618 586 1961333 SGTC_947 3447-0010 211 µM -0.0778916247216605 0.487705796212786 no 1733 0.468957130837268 594 748350 SGTC_2490 carminic acid 95.39 µM -0.0783953350547715 0.487507926591322 no 1734 0.468756792099739 575 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1339 1486-1321 22.7 µM -0.0785878130506928 0.487432317381026 no 1735 0.468680240666721 589 3469382 SGTC_2353 9059630 146.67 µM -0.0796499377090188 0.487015101748361 no 1736 0.468257838400494 600 4779114 SGTC_348 k064-0012 10.7 µM -0.0797226439825884 0.486986542344148 no 1737 0.468228924739307 590 5066323 SGTC_304 1310-0298 97 µM -0.080877184625849 0.486533041787539 no 1738 0.467769812272449 580 1550234 SGTC_1106 tegaserod maleate 11.7 µM -0.0809014036105613 0.486523528817885 no 1739 0.467760181853344 592 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_928 2764-0428 58.7 µM -0.0811565430805575 0.486423313108807 no 1740 0.467658729531394 585 662578 SGTC_2998 9066762 71.4286 µM -0.0813929099435157 0.486330471818483 no 1741 0.467564743724912 583 4945196 SGTC_872 0588-0139 234 µM -0.0817552390974032 0.48618815590599 no 1742 0.46742067544401 580 2047100 SGTC_1431 4049-0260 9.09 µM -0.0819868027158963 0.486097203097208 no 1743 0.467328604014987 577 3854841 SGTC_1466 k213-0079 57.5 µM -0.0820983512569999 0.486053389679991 no 1744 0.46728425210312 590 3657981 SGTC_2350 9023895 38.85 µM -0.0829018172782728 0.485737813758639 no 1745 0.466964804519122 578 2997209 SGTC_1473 k844-0725 134 µM -0.0854689234490562 0.484729596854926 no 1746 0.465944300270262 575 54682906 SGTC_525 k781-2675 26.7 µM -0.0866096800312581 0.484281601892852 no 1747 0.465490885632444 571 3651118 YDL195W SEC31 SGTC_18 0111-0177 500 nM -0.0870628037739953 0.48410365778782 no 1748 0.465310795683432 593 721752 SGTC_1606 st000094 49.2 µM -0.0872575580687301 0.484027177710618 no 1749 0.465233394524503 578 1242210 SGTC_3305 9127027 53.8275 µM -0.0876093976163198 0.483889011693365 no 1750 0.465093566342692 597 41905295 SGTC_739 1486-1183 203 µM -0.0876207801013313 0.483884541868137 no 1751 0.46508904278386 596 4346692 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.0880863324446984 0.483701724339172 no 1752 0.464904029640077 602 5393153 SGTC_1448 4255-0083 152 µM -0.0885799760573869 0.483507879406533 no 1753 0.464707861154811 630 5399660 SGTC_3022 9087993 49.47 µM -0.0926492749720016 0.481910091925319 no 1754 0.463091098150048 571 17173644 SGTC_252 miconazole 1.30953 nM -0.0935509275659175 0.481556101489731 no 1755 0.462732946351869 598 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1802 st050112 57.9 µM -0.0938965637570918 0.481420407937742 no 1756 0.46259566175193 584 4662563 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.0939296684987824 0.481407411436954 no 1757 0.462582512982751 605 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_586 0957-0265 8.15 µM -0.0948017831806742 0.481065037457759 no 1758 0.462236135240043 594 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2677 mitomycin C 100 µM -0.095370445689528 0.480841799960007 no 1759 0.462010294988736 593 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.0964546109010857 0.480416210395036 no 1760 0.461579760518326 624 689007 SGTC_1204 4049-0315 18.3 µM -0.0968664757302826 0.480254538486611 no 1761 0.46141621603207 591 588402 SGTC_1634 st006576 41 µM -0.0981654207220283 0.479744676786835 no 1762 0.46090047003722 583 3915356 SGTC_2061 5245884 80.95 µM -0.0982357851129299 0.479717058305033 no 1763 0.460872533731826 604 573863 SGTC_982 1491-0518 27.5 µM -0.098267213398032 0.47970472252985 no 1764 0.460860056031526 587 3091256 SGTC_873 0591-4978 488 µM -0.0984237785494557 0.479643270134542 no 1765 0.460797896897545 586 3305145 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.0985658930942477 0.479587490074148 no 1766 0.460741475739234 606 77254 SGTC_1039 k821-0043 94 µM -0.100540345277473 0.478812558024178 no 1767 0.459957677093866 575 15992768 SGTC_1760 st045453 10.4495 µM -0.101515576287235 0.478429829188552 no 1768 0.459570596672276 593 3323419 YIL048W NEO1 SGTC_2222 6885208 172.143 µM -0.101594336739315 0.478398920558835 no 1769 0.459539337409045 585 609514 SGTC_458 nppb 133 µM -0.102852836745696 0.477905054516174 no 1770 0.459039884963074 595 4549 A chloride channel blocker. SGTC_2147 5545932 89.7195 µM -0.10371826860893 0.477565457624382 no 1771 0.458696464296312 606 797404 SGTC_2338 7999974 200 µM -0.103877884983767 0.477502825667382 no 1772 0.458633128686683 609 315925 SGTC_2009 4012297 12.05 µM -0.104071700871829 0.477426774891763 no 1773 0.458556224158078 623 45595307 SGTC_3020 9089140 49.47 µM -0.104760012134372 0.47715669737352 no 1774 0.458283120543478 590 17217859 SGTC_45 0kpi-0036 14.9 µM -0.105103800939266 0.477021806469731 no 1775 0.458146721649189 581 2795021 SGTC_905 2-aminofluorene 215 µM -0.105904627473757 0.47670759991471 no 1776 0.457829011262796 587 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.106957553288817 0.476294503561428 no 1777 0.457411327043313 590 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_634 1611-4317 11.2 µM -0.107282132526073 0.476167165899025 no 1778 0.4572825794533 600 2843522 SGTC_2252 omeprazole 400 µM -0.107615428074392 0.476036411220304 no 1779 0.457150379117055 622 4594 A proton pump inhibitor. SGTC_1970 st070122 35.8 µM -0.107956829894401 0.475902479057644 no 1780 0.457014968376961 621 102928 SGTC_1783 st039459 87.517 µM -0.108048736886802 0.475866424347447 no 1781 0.456978516014162 593 729761 SGTC_431 k089-0097 107 µM -0.108111470590574 0.475841814303936 no 1782 0.456953634636076 624 5499420 SGTC_2119 5528445 120.635 µM -0.109582632960508 0.475264713038639 no 1783 0.456370192294244 604 791935 SGTC_973 1325-0077 65.9 µM -0.11029381734238 0.474985751209792 no 1784 0.45608818019842 609 2835149 SGTC_2006 4011487 200 µM -0.111121075738747 0.474661274825931 no 1785 0.45576016810898 592 45595294 SGTC_1915 st067105 30.6 µM -0.113182861993014 0.473852651958122 no 1786 0.454942791250482 605 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1868 st057644 42.7 µM -0.113788384681371 0.47361518912351 no 1787 0.454702773233542 600 688665 SGTC_1280 0880-0253 10.1 µM -0.11379916149707 0.473610962953314 no 1788 0.454698501652239 626 6836607 SGTC_72 0744-0168 198.391 µM -0.114034843878922 0.473518539934043 no 1789 0.454605086087094 659 677577 SGTC_1470 k295-0292 231 µM -0.114561910467668 0.473311855549677 no 1790 0.454396185957114 592 5045612 SGTC_1359 1582-0056 520 nM -0.116815611033289 0.472428169027558 no 1791 0.453503086317369 614 3661189 SGTC_1754 st042065 16.137 µM -0.11704396554155 0.472338637656541 no 1792 0.453412606713006 603 1126236 YIL048W NEO1 SGTC_621 3584-0052 32.1 µM -0.117327004317668 0.472227668064531 no 1793 0.45330046322986 620 2273927 SGTC_1907 st060210 83.7 µM -0.117548412668171 0.472140863106398 no 1794 0.453212741083332 624 688793 SGTC_3000 9075062 71.4286 µM -0.117786173065374 0.472047648667931 no 1795 0.453118542786535 575 17057871 SGTC_66 0109-0187 42.4 µM -0.118330419819447 0.471834281412911 no 1796 0.452902927592459 596 759417 SGTC_229 benomyl 22.8748 µM -0.118636982656639 0.47171409964649 no 1797 0.452781482163334 606 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_358 0075-0058 9.45 µM -0.119284177500581 0.471460388455567 no 1798 0.452525109259861 673 1069125 SGTC_2567 aureobasidin a 60 nM -0.119912024728243 0.47121427291998 no 1799 0.452276419427573 600 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1993 st073995 70.8 µM -0.1200640939436 0.471154663577692 no 1800 0.452216187734304 599 3098394 SGTC_506 n9-isopropylolomoucine 153 µM -0.121468168335292 0.470604313646896 no 1801 0.451660112985587 589 6610355 SGTC_126 0417-1624 672.48 µM -0.121566412665706 0.470565807263507 no 1802 0.451621207479556 616 41912 YDL195W SEC31 SGTC_1572 epiandrosterone 68.9 µM -0.122135005350823 0.470342955566595 no 1803 0.451396049566848 586 441302 A steroid. SGTC_1005 4092-0690 4.4 µM -0.123088712574228 0.469969184674536 no 1804 0.451018424685263 623 1529343 SGTC_183 3914-0051 30.55 µM -0.123898103245652 0.469651994154199 no 1805 0.450697977384035 594 1596232 SGTC_3031 9088762 49.47 µM -0.125094525403843 0.469183165955368 no 1806 0.450224358673779 611 205253 SGTC_161 4065-0411 162.148 µM -0.125303176511609 0.469101408601164 no 1807 0.450141768756594 633 1906281 YLR208W SEC13 SGTC_567 1080-0542 68.4 µM -0.126062139882469 0.468804029212053 no 1808 0.449841368163456 594 5950415 SGTC_1237 0330-0133 46.1 µM -0.127368336319143 0.468292272104694 no 1809 0.449324438028177 625 X1237 YHR072W ERG7 SGTC_2312 7706453 155.7 µM -0.127461175355831 0.46825590051184 no 1810 0.449287700036626 618 976098 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.128576057505443 0.46781914339385 no 1811 0.448846556185331 658 6710655 SGTC_936 3005-4620 401 µM -0.130161594054151 0.467198073397822 no 1812 0.448219289765232 600 777207 SGTC_3280 9140961 49.47 µM -0.130663241519425 0.467001589792156 no 1813 0.448020855999666 614 4901226 SGTC_718 1130-0073 349 µM -0.131040199458842 0.466853949452585 no 1814 0.447871753499608 632 6740020 SGTC_147 4466-0538 29.23 µM -0.133111081279751 0.466042944308998 no 1815 0.44705276577144 637 6742687 YHR072W ERG7 SGTC_137 0438-0332 85.389 µM -0.133175914405965 0.466017556418187 no 1816 0.447027129337234 628 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2928 9011484 9.79 µM -0.133906290516476 0.465731559289531 no 1817 0.446738337987743 638 2994751 SGTC_295 k015-0027 31 µM -0.134428159964408 0.465527219018439 no 1818 0.446532007644916 625 3887424 SGTC_2726 cimetidine 79.27 µM -0.134600969941961 0.465459556514344 no 1819 0.446463687342451 611 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_185 k048-0037 25.491 µM -0.134758829472111 0.465397748623088 no 1820 0.44640127907761 596 6827589 SGTC_1798 st045719 60.953 µM -0.136532317438644 0.464703419681697 no 1821 0.445700239063837 595 3980186 SGTC_801 0866-0028 10.1 µM -0.137102284330811 0.464480297659497 no 1822 0.445474973443258 590 6849771 SGTC_2253 7938677 135.83 µM -0.137531025851961 0.464312467767389 no 1823 0.445305535329439 620 2301972 SGTC_1967 st070177 51.4 µM -0.138345605105689 0.463993620089942 no 1824 0.444983642173356 625 5729214 SGTC_2957 9076800 11.52 µM -0.138855012420342 0.463794236449839 no 1825 0.444782360687566 631 16459615 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.139431298853875 0.463568687075006 no 1826 0.444554670503773 600 16623 A steroid. SGTC_2054 5233173 129 µM -0.139478988934305 0.463550022457115 no 1827 0.444535829020106 614 6889 SGTC_1349 flufenamic acid 69 µM -0.139520888706961 0.463533624076533 no 1828 0.444519275285186 620 3371 A non-steroidal anti-inflammatory. SGTC_2864 9034755 47.6 µM -0.13980437260272 0.463422678163018 no 1829 0.444407279195767 595 4930451 SGTC_1173 0443-0020 122 µM -0.141568530624768 0.462732311245675 no 1830 0.443710412725174 620 5331295 SGTC_2007 4011539 71.82 µM -0.141916407416981 0.462596190008858 no 1831 0.443573017123274 589 45595301 SGTC_3331 9141060 1.957 µM -0.142220200663958 0.462477321871367 no 1832 0.443453038075828 623 4906567 YPR165W RHO1 SGTC_2160 5660466 132.927 µM -0.144093548799453 0.461744393175817 no 1833 0.442713299436384 670 2859134 SGTC_2897 9048598 12.99 µM -0.144643482821872 0.461529261549453 no 1834 0.442496181947149 608 6467404 SGTC_3070 9117005 49.47 µM -0.145139315310454 0.46133530383893 no 1835 0.442300438894548 603 8779016 SGTC_2863 9028737 58.44 µM -0.145702603762046 0.461114970143323 no 1836 0.442078082901355 653 6460917 SGTC_2098 5376439 882.5 nM -0.146859979356181 0.460662293188863 no 1837 0.441621270591425 618 2844116 SGTC_2936 9038235 15.59 µM -0.148005076453766 0.460214468807396 no 1838 0.441169380968934 599 4749415 SGTC_1198 1612-1005 86.7 µM -0.148277470540099 0.460107948382125 no 1839 0.441061897354739 611 6998509 SGTC_1100 amiodarone 5.07 µM -0.148395256716198 0.460061888673791 no 1840 0.441015421610763 610 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_3283 9109332 35.8195 µM -0.148403136394197 0.46005880738335 no 1841 0.441012312498169 599 17027281 SGTC_946 3434-1334 87.4 µM -0.149210571533074 0.459743078528132 no 1842 0.440693739249454 608 4047976 SGTC_1834 st055981 52.8 µM -0.150084650257331 0.459401318858718 no 1843 0.440348915064926 635 471719 YDL150W RPC53 SGTC_2882 9058044 58.44 µM -0.150145452253637 0.459377546746805 no 1844 0.440324930348192 633 18076804 SGTC_3167 9103034 49.47 µM -0.150199656239332 0.459356354420122 no 1845 0.440303548549939 607 5127859 SGTC_2407 paclitaxel 400 µM -0.153520236877733 0.458058317636241 no 1846 0.438994016375084 708 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3105 9121040 49.47 µM -0.153766637124169 0.457962015813995 no 1847 0.438896870322456 611 41448907 SGTC_2959 9079155 11 µM -0.153853270627142 0.45792815700129 no 1848 0.438862714969344 617 16189457 SGTC_19 0279-0214 38.434 µM -0.154155029773372 0.457810223414293 no 1849 0.438743749652673 600 3566274 YBR002C RER2 SGTC_2383 9036125 200 µM -0.154345252400704 0.457735882466385 no 1850 0.438668759258972 614 79580 SGTC_1067 clotrimazole 1.36 µM -0.156083243381201 0.457056726614593 no 1851 0.437983703161644 602 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1051 3253-3903 78 µM -0.15642877606218 0.456921717468171 no 1852 0.437847528175601 602 5509239 SGTC_2258 7960471 200 µM -0.156826431572548 0.456766348649673 no 1853 0.437690820608923 654 2974708 SGTC_1028 k015-0029 4.8 µM -0.157820914038285 0.45637782130199 no 1854 0.437298959084053 602 4588309 SGTC_884 0851-0618 334 µM -0.158902630353526 0.455955260538147 no 1855 0.436872794153058 655 9642473 SGTC_757 1066-0008 322 µM -0.15920061960138 0.455838862996841 no 1856 0.4367554078586 624 6842497 SGTC_2248 tofa 1.1 µM -0.159696006268613 0.455645368467879 no 1857 0.436560273531538 628 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_251 melphalan 456.522 µM -0.160175068964806 0.455458259972048 no 1858 0.436371583948319 628 460612 A DNA alkylator. SGTC_2518 prenyletin 46.28 µM -0.16017950119786 0.455456528911791 no 1859 0.436369838281493 601 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1353 1498-1206 8.11 µM -0.160233560350685 0.455435415547919 no 1860 0.436348546795586 619 6756808 SGTC_1197 1601-0112 267 µM -0.160349941573599 0.455389962079218 no 1861 0.436302710055691 623 7350313 SGTC_351 caspofungin 25 nM -0.160520290891655 0.45532343206137 no 1862 0.436235619526236 607 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2489 cantharidin 73.42 µM -0.161647084929917 0.454883393684453 no 1863 0.435791888233298 618 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1759 st043059 70 µM -0.163152231164944 0.454295686728085 no 1864 0.43519928808285 649 669426 SGTC_1335 1486-0900 202 µM -0.16373615202639 0.454067712921763 no 1865 0.434969428201098 604 X1335 SGTC_338 4055-0136 114 µM -0.163883153022926 0.4540103233191 no 1866 0.434911564860677 607 2900563 SGTC_752 1896-0090 130 µM -0.164026257506191 0.453954455848535 no 1867 0.434855236626255 620 772567 SGTC_2667 digitoxin 100 µM -0.164065831531948 0.45393900645336 no 1868 0.434839659884288 612 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_164 4100-3994 89.624 µM -0.164372493910661 0.453819290184542 no 1869 0.434718957860495 614 4615967 SGTC_2276 7947513 42.08 µM -0.165029779953936 0.453562709986578 no 1870 0.434460271201448 655 2105100 SGTC_2308 7584454 197.62 µM -0.165734571778846 0.45328760682264 no 1871 0.434182918970572 655 893577 SGTC_2271 7849410 118.62 µM -0.165743934282124 0.453283952483786 no 1872 0.434179234822114 609 972430 SGTC_978 1416-0512 87.4 µM -0.166408241560812 0.45302467255505 no 1873 0.433917844277885 628 6814003 SGTC_2754 granisetron 64.02 µM -0.167630975315239 0.452547490534091 no 1874 0.433436800613337 650 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1673 st016611 27.3 µM -0.168380348451489 0.452255075257646 no 1875 0.433142033519659 654 5226799 SGTC_899 1083-0020 478 µM -0.1689811245641 0.452020663193858 no 1876 0.432905744149869 666 767123 SGTC_988 1497-1057 103 µM -0.170108720988575 0.451580740512131 no 1877 0.432462317560122 628 3533044 SGTC_819 1013-0258 27.7 µM -0.170180594854738 0.45155270151087 no 1878 0.432434056084604 649 5753198 SGTC_3069 9117009 49.47 µM -0.170686282446543 0.451355432543044 no 1879 0.432235224780118 611 41904981 SGTC_1151 3909-8316 15.3 µM -0.170793054768401 0.45131378214429 no 1880 0.432193245163434 663 800431 SGTC_2238 6671620 73.2395 µM -0.171133791463847 0.4511808690819 no 1881 0.432059283020988 622 729941 SGTC_2151 5563267 85.4165 µM -0.17175205913417 0.45093971195082 no 1882 0.43181622830171 635 5310824 SGTC_301 4119-0100 24.5 µM -0.175014939928008 0.449667317693947 no 1883 0.430533947200943 643 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2272 7805186 180 µM -0.176664742717846 0.449024156049338 no 1884 0.429885868221725 677 2956062 YPR165W RHO1 SGTC_1464 k208-0027 110 µM -0.176688152516352 0.449015030897318 no 1885 0.429876673690663 612 X1464 SGTC_738 1315-0003 72.4 µM -0.178686211980818 0.448236286121654 no 1886 0.429092048092418 666 6251474 SGTC_2854 9024559 71.43 µM -0.179667437829717 0.447853925639188 no 1887 0.428706829125875 657 3163529 SGTC_1087 pterostilbene 9.05 µM -0.180426405062059 0.447558207288472 no 1888 0.428408913115939 633 5281727 Similar to reservatol, lowers cholesterol. SGTC_822 1487-0950 154 µM -0.181408169309071 0.447175723226577 no 1889 0.428023603541453 637 1958375 SGTC_2132 5317594 122.667 µM -0.183363980848941 0.446413908292331 no 1890 0.42725621789868 621 794577 SGTC_2635 hydroquinidine 100 µM -0.183497916481043 0.446361745762329 no 1891 0.427203676713761 614 442912 An experimental heart treatment. SGTC_2078 5212016 200 µM -0.183584210115068 0.446328138361814 no 1892 0.427169825541315 629 1899708 SGTC_3004 9076122 71.4286 µM -0.184196837352627 0.446089559334692 no 1893 0.426929520230093 655 44782551 SGTC_3151 9099821 49.47 µM -0.185944628583704 0.445409014273194 no 1894 0.426244091948266 669 17174189 SGTC_714 4296-0578 26.1 µM -0.186463597477699 0.445206971979306 no 1895 0.426040611602956 615 1589775 SGTC_1498 4478-3555 97.6 µM -0.188009612164868 0.444605170062735 no 1896 0.425434558066098 635 3437919 SGTC_1268 0828-0275 2.46 µM -0.188041769832644 0.444592653714638 no 1897 0.425421953797191 644 745337 SGTC_1963 st076565 50.3 µM -0.189287218055643 0.444107945280531 no 1898 0.424933856375077 620 4914280 SGTC_2073 5212005 126 µM -0.190456644436995 0.443652899401116 no 1899 0.424475657015672 631 691789 SGTC_1810 st050138 53 µM -0.19076184342828 0.443534152912014 no 1900 0.424356092092327 650 3444541 SGTC_1368 1852-0141 284 µM -0.193634822511056 0.442416587312019 no 1901 0.423230914891235 647 2838987 SGTC_2733 amorolfine 100 µM -0.194561825859999 0.442056087836347 no 1902 0.42286799521549 635 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_490 phenamil 164 µM -0.195725506300988 0.441603615694278 no 1903 0.422412509688325 637 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1445 4239-0156 97.7 µM -0.19657308534631 0.441274100715839 no 1904 0.422080817210314 676 4008346 SGTC_582 0987-0078 156 µM -0.198901074211819 0.440369253701701 no 1905 0.421170064602337 625 1625765 SGTC_1906 st060206 94.7 µM -0.199882022730339 0.439988069770184 no 1906 0.420786425254428 632 5133468 SGTC_2034 5197015 53.07 µM -0.201244663407646 0.43945865755948 no 1907 0.420253634729324 675 780676 SGTC_2319 6033012 152.6 µM -0.201451741983644 0.439378212987449 no 1908 0.420172680070434 625 847246 SGTC_140 0062-0056 502.533 µM -0.201964866388991 0.439178888466339 no 1909 0.419972095359167 639 3758964 SGTC_1222 0366-0074 1.18 µM -0.202163280442279 0.439101818138454 no 1910 0.419894539181586 662 286520 SGTC_689 0833-0039 98 µM -0.202730601370358 0.43888146539618 no 1911 0.419672801686796 672 5374726 SGTC_986 1493-0483 84 µM -0.203050851453741 0.438757085634956 no 1912 0.419547643135938 647 40079 SGTC_2288 7946289 167.31 µM -0.203279348999319 0.438668344716729 no 1913 0.419458347831506 670 1246052 SGTC_1723 st034307 2.5525 µM -0.204293158141795 0.438274651895523 no 1914 0.419062208121848 624 867466 SGTC_706 4262-0057 46.9 µM -0.204368675724271 0.438245328568596 no 1915 0.419032703367509 639 883298 SGTC_2985 9022375 71.43 µM -0.206182091840743 0.437541284889663 no 1916 0.418324337978625 680 4939335 SGTC_2245 6637752 200 µM -0.206296991318432 0.437496682762941 no 1917 0.418279464285175 636 681890 SGTC_1738 st035555 74 µM -0.206917631570152 0.437255773958944 no 1918 0.418037093246381 680 5331140 SGTC_397 arbidol 50 µM -0.207207766278854 0.437143162737154 no 1919 0.417923801160942 627 131410 A RNA synthesis inhibitor. SGTC_3198 9112019 49.47 µM -0.207550220949124 0.437010250898892 no 1920 0.41779008789004 670 45595555 SGTC_2020 4017018 200 µM -0.208150000267397 0.436777484610226 no 1921 0.417555923731201 661 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2821 7996764 71.43 µM -0.208306256667274 0.436716847193035 no 1922 0.417494923342514 616 2987135 SGTC_2229 7354935 190 µM -0.208653481524109 0.4365821071989 no 1923 0.417359378556938 648 318112 SGTC_1320 1313-0481 95.3 µM -0.208688114465889 0.436568668350118 no 1924 0.417345859571591 618 6813365 YLR208W SEC13 SGTC_3032 9089427 49.47 µM -0.211387938001761 0.435521264533571 no 1925 0.416292284085844 629 17173707 SGTC_3098 9119039 49.47 µM -0.211888958774743 0.435326941696539 no 1926 0.416096832324556 615 17161528 SGTC_203 k066-0004 30.888 µM -0.211968046203305 0.435296268758629 no 1927 0.416065981651947 643 6795412 SGTC_2358 9037157 4 µM -0.212626953816263 0.435040735932877 no 1928 0.41580897302116 629 2388925 SGTC_1874 staurosporine 7.6 µM -0.213250595215716 0.434798904783918 no 1929 0.415565753232825 637 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_780 0109-0199 192 µM -0.213750901101651 0.434604917415464 no 1930 0.415370657601511 637 610414 SGTC_3276 9139060 49.47 µM -0.214042280062059 0.434491946108373 no 1931 0.415257043199435 669 4870619 SGTC_761 k216-0224 480 µM -0.214121594001192 0.434461196017112 no 1932 0.415226118357128 713 1340404 SGTC_1116 jasmonic acid  1.58368 µM -0.215072287960606 0.434092641957661 no 1933 0.414855479666323 672 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2444 5485484 36.41 µM -0.215862014172847 0.43378653355785 no 1934 0.414547653658394 681 6790631 SGTC_990 3985-0011 41.3 µM -0.217539253263074 0.43313654528459 no 1935 0.413894059834182 685 5399565 YGL099W LSG1 SGTC_2712 st079126 47.7 µM -0.218592223907749 0.432728574956054 no 1936 0.413483855372032 657 3152970 SGTC_1033 k072-0102 21.3 µM -0.219009947934039 0.43256674887022 no 1937 0.413321149274192 638 5965931 SGTC_477 mead ethanolamide 10 µM -0.219735770030655 0.432285592655916 no 1938 0.413038472484496 621 16061185 SGTC_668 1682-0499 62.6 µM -0.22042987760248 0.432016753527162 no 1939 0.412768189318022 633 682214 SGTC_1683 st010134 710 nM -0.221942604807395 0.431430958949285 no 1940 0.412179281835257 688 3818134 SGTC_585 0kpi-0023 191 µM -0.223193214849006 0.430946781470898 no 1941 0.411692566262891 661 64601 SGTC_2158 5657123 3.6195 µM -0.223588709122714 0.430793686222479 no 1942 0.411538675039973 710 2858827 SGTC_2762 leflunomide 42.06 µM -0.225153005562146 0.430188251516089 no 1943 0.410930123461843 643 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1088 bifonazole 369 nM -0.225233754636347 0.430157003382736 no 1944 0.410898715798007 647 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2033 5192550 145 µM -0.226433774562896 0.429692673460434 no 1945 0.410432030847263 628 182073 SGTC_2555 cholic acid 100 µM -0.226881263334461 0.429519549170086 no 1946 0.410258035929704 651 6708657 Influences liver metabolism. SGTC_453 enantio-paf c16 10 µM -0.227581771478659 0.429248564066382 no 1947 0.409985696182318 678 13871343 A lipid and platelet activating factor SGTC_2738 aclarubicin 5.55 µM -0.228693161204496 0.428818701675054 no 1948 0.409553705256621 654 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_618 k072-0232 33.2 µM -0.230023076129645 0.428304429278926 no 1949 0.409036919145782 680 5872756 YGL099W LSG1 SGTC_1276 0871-0068 94.2 µM -0.230470595344041 0.428131402849708 no 1950 0.408863055016115 635 3414906 SGTC_1413 3910-0535 34.4 µM -0.232311980488534 0.42741960531306 no 1951 0.408147853937254 649 2876951 SGTC_549 1661-1316 519 µM -0.232543131031676 0.427330269440183 no 1952 0.408058095737934 673 2857282 SGTC_720 r052-1644 49.9 µM -0.234903189823453 0.426418359671086 no 1953 0.407141936858301 674 1422863 YOR257W CDC31 SGTC_2756 carbadox 75.1 µM -0.236987318681475 0.425613394029959 no 1954 0.406333314144243 636 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1860 st056228 74.6 µM -0.237953476427319 0.42524033404202 no 1955 0.405958589132822 700 688679 SGTC_5 0352-0601 109.883 µM -0.238453175390797 0.425047412814226 no 1956 0.405764814288494 664 762456 SGTC_1307 1187-1599 12.2 µM -0.241168364850641 0.423999461195915 no 1957 0.404712314265803 653 1538471 SGTC_592 k241-0073 46.5 µM -0.244364270619223 0.422766661577401 no 1958 0.403474355499403 679 4230158 SGTC_501 nsc-95397 161 µM -0.244880840174679 0.422567468930153 no 1959 0.403274348711511 674 262093 SGTC_1258 0671-0043 57.1 µM -0.244890572921456 0.422563716108312 no 1960 0.403270580603136 698 4298767 SGTC_2303 7774051 200 µM -0.245341347260786 0.422389911034053 no 1961 0.403096069668923 690 2953184 SGTC_2971 9092186 9.93 µM -0.245413825610063 0.422361966964186 no 1962 0.40306801249727 627 25236400 SGTC_1694 st024011 44.9 µM -0.245598692225833 0.422290693302409 no 1963 0.402996450843182 683 2787533 SGTC_1063 disulfiram 1.84 µM -0.246322872527648 0.422011516626268 no 1964 0.402716152796333 642 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3150 9097574 49.47 µM -0.247239254683915 0.421658300943977 no 1965 0.402361533621723 696 17217476 SGTC_404 fumagillin 50 µM -0.247709936139351 0.421476903218889 no 1966 0.402179421751421 654 12015870 A methionine aminopeptidase binder. SGTC_715 0868-0130 184 µM -0.248808126576655 0.421053732268217 no 1967 0.401754602327597 653 2876258 SGTC_3115 9123671 49.47 µM -0.249617522183617 0.420741902348122 no 1968 0.40144157336135 642 3286988 SGTC_955 1216-0110 33 µM -0.250336050950185 0.420465121688081 no 1969 0.401163739589627 643 3619719 SGTC_1145 3546-0597 10.2 µM -0.251112960511119 0.420165896716346 no 1970 0.40086338792525 652 875334 SGTC_2438 5259590 200 µM -0.25112204856391 0.420162396745906 no 1971 0.400859874848793 665 1201127 SGTC_2728 chlorpromazine 9.18 µM -0.255286848486656 0.41855912707702 no 1972 0.399250778446335 655 2726 A thorazine and dopamine antagonist. SGTC_2287 7945887 168.79 µM -0.256490930655545 0.418095857744766 no 1973 0.398785891282108 666 1245853 SGTC_2847 9005661 71.43 µM -0.257362469196495 0.417760605060857 no 1974 0.398449486258863 636 2991449 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.257851884861402 0.417572368872151 no 1975 0.398260609848539 658 5106787 A p450 inhibitor. SGTC_1501 4491-0275 38.4 µM -0.25845138653282 0.41734181778842 no 1976 0.398029281278319 677 5104718 SGTC_963 1269-2853 151 µM -0.259886424581468 0.416790059029593 no 1977 0.397475691594988 641 3668223 SGTC_649 1123-0311 367 µM -0.260944657756018 0.416383283151206 no 1978 0.39706759280549 676 693629 YIL048W NEO1 SGTC_2055 5235184 200 µM -0.262109517983435 0.415935624272715 no 1979 0.39661850447856 711 2836034 SGTC_2293 7624732 200 µM -0.262907138372075 0.415629159504402 no 1980 0.396311077093953 662 894453 SGTC_217 ketoconazole 989 nM -0.263870284534848 0.41525916419048 no 1981 0.395939936925786 648 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_3014 9081533 49.47 µM -0.265617216602102 0.414588267254417 no 1982 0.395267012421263 700 21367265 SGTC_3191 9110352 49.47 µM -0.265826351238618 0.414507967228761 no 1983 0.395186473893934 658 17122424 SGTC_3207 9114163 49.47 µM -0.266310383146891 0.414322130448101 no 1984 0.395000088582013 727 849233 SGTC_2134 5324836 1.464 µM -0.268548611560354 0.413463046289293 no 1985 0.394138530950836 641 699272 SGTC_3209 9113616 49.47 µM -0.270460369829177 0.412729596697302 no 1986 0.393403050730036 701 16649353 SGTC_3314 9135860 59.4275 µM -0.271823247775328 0.412206911862518 no 1987 0.39287896444619 650 25252478 SGTC_1375 2910-0797 186 µM -0.272682753385199 0.411877358119784 no 1988 0.392548546637087 668 742508 SGTC_1939 st074455 53.6 µM -0.274876036308747 0.411036686356413 no 1989 0.391705739243059 710 1644229 SGTC_133 0724-0033 378.92 µM -0.27563177802965 0.410747109646756 no 1990 0.391415449723903 661 280309 SGTC_1841 st054148 70 µM -0.27631852765601 0.410484010737832 no 1991 0.391151713332455 700 675442 SGTC_2831 7999036 19.48 µM -0.278369488323686 0.409698512608781 no 1992 0.390364369505253 722 2988270 SGTC_3146 9095609 49.47 µM -0.278610749432606 0.409606135689894 no 1993 0.390271781196539 658 17173999 SGTC_3170 9103054 49.47 µM -0.279511910330748 0.409261132918832 no 1994 0.389925999499807 691 16432970 SGTC_569 4130-2812 160 µM -0.279612440566031 0.409222650015259 no 1995 0.389887430744824 699 743552 SGTC_2015 5119600 184 µM -0.279792710059555 0.409153645170673 no 1996 0.389818272476784 701 2828786 SGTC_1624 st003710 6.25 µM -0.280911572915794 0.408725421891268 no 1997 0.389389112009457 709 24207033 SGTC_226 1,3-diallylurea 8.28947 mM -0.281445105971851 0.408521260684778 no 1998 0.389184513031916 671 74537 YKL182W FAS1 SGTC_2367 9070478 135.38 µM -0.283073305182907 0.407898369360549 no 1999 0.388560322201145 646 572802 SGTC_985 1493-0307 8.71 µM -0.283372064956849 0.407784099679765 no 2000 0.388445820035409 694 3278274 SGTC_2629 bisabolol 100 µM -0.283550551429862 0.40771583589069 no 2001 0.388377418236381 694 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_359 0081-0058 15.9 µM -0.283906068913282 0.407579873317794 no 2002 0.388241182735436 702 3494159 SGTC_2279 7948423 32.93 µM -0.284169559359902 0.407479112349395 no 2003 0.388140221176902 654 1247112 SGTC_1347 1493-0251 600 nM -0.284686118650087 0.407281593489948 no 2004 0.387942313244839 670 3986378 SGTC_3144 9087057 49.47 µM -0.285625973082644 0.406922278057576 no 2005 0.387582304093315 744 17249618 SGTC_2994 9053520 71.4286 µM -0.285941818336834 0.4068015449346 no 2006 0.387461341949312 716 4647384 SGTC_2502 avocadyne acetate 18.59 µM -0.286270265294358 0.406676004154027 no 2007 0.387335565202427 652 3952079 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.287296356720722 0.406283867751336 no 2008 0.386942706023594 669 2333 A French combination drug. SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.288127511418128 0.405966298252205 no 2009 0.38662456705434 666 16725076 SGTC_3226 9131256 49.47 µM -0.28954319601979 0.405425532752596 no 2010 0.386082864547717 658 17178073 SGTC_2168 5727979 200 µM -0.289649130830805 0.405385074846744 no 2011 0.386042338196416 650 695210 SGTC_1393 3470-5649 58.2 µM -0.289674269390692 0.405375474246533 no 2012 0.386032721388095 690 4108395 SGTC_1159 4092-0538 61.2 µM -0.289885991512863 0.405294618276315 no 2013 0.385951729429471 656 717301 SGTC_454 lyso-paf C-16 6.67 µM -0.289898940185904 0.405289673352515 no 2014 0.385946776218927 703 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_545 4218-0007 221 µM -0.290586091037017 0.405027281407323 no 2015 0.385683949503727 699 2840508 SGTC_1719 st032227 49.2 µM -0.292495398244146 0.404298427476082 no 2016 0.384953938898766 654 3125804 SGTC_2458 5808907 16.39 µM -0.292627338197192 0.404248073300613 no 2017 0.384903507583995 703 2731747 SGTC_1968 st069590 43.6 µM -0.293617586421659 0.403870201061363 no 2018 0.384525067907885 681 6384066 SGTC_879 0831-1030 162 µM -0.293900573962585 0.403762231331914 no 2019 0.384416939753663 679 1549252 SGTC_1979 st071809 45.3 µM -0.294158641517939 0.403663775848424 no 2020 0.384318341243435 712 4976333 SGTC_320 4092-0846 5.34 µM -0.295223836982454 0.403257457250069 no 2021 0.383911446898723 664 1359356 SGTC_1462 k081-0014 26.5 µM -0.295537166883741 0.403137957477218 no 2022 0.383791782245314 701 3270634 SGTC_3282 9108498 15.4605 µM -0.29743249322441 0.40241529895673 no 2023 0.383068169753227 691 16459645 SGTC_1038 k292-0204 154 µM -0.298704697572628 0.401930414004667 no 2024 0.382582686232785 663 4454212 SGTC_2969 9091408 28.7 µM -0.299697601872307 0.401552085620544 no 2025 0.382203914002148 677 4286311 SGTC_3184 9108758 49.47 µM -0.299970927924686 0.401447955807424 no 2026 0.382099665594692 685 902885 SGTC_1984 st072354 53.1 µM -0.300038305992497 0.401422287665867 no 2027 0.382073968456197 677 5762938 SGTC_2765 myclobutanil 7.74 µM -0.300056263793568 0.401415446588972 no 2028 0.382067119666838 724 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2320 7373003 200 µM -0.301731773822768 0.400777289349165 no 2029 0.381428272245836 690 5415828 SGTC_1933 st074711 15.9 µM -0.301788776099622 0.400755583343305 no 2030 0.381406543783125 663 17250958 SGTC_2326 6164455 177.58 µM -0.302382496629589 0.400529517598044 no 2031 0.381180248138151 683 2888790 SGTC_1386 3228-0095 33.8 µM -0.302702039126177 0.400407861997222 no 2032 0.381058471829556 717 870181 SGTC_1983 st071813 46.9 µM -0.302757186437085 0.400386867397018 no 2033 0.381037456611547 683 11838595 SGTC_3139 9095020 49.47 µM -0.304151480051758 0.399856155126099 no 2034 0.38050624400841 643 25236292 SGTC_308 4092-1169 104 µM -0.304202328329532 0.399836804151766 no 2035 0.380486875549272 681 2268590 YDL196W YDL196W SGTC_2933 9026794 32.47 µM -0.304397401062854 0.399762568964996 no 2036 0.380412573781638 705 17586027 SGTC_749 1000-0129 128 µM -0.304616638355632 0.399679142247209 no 2037 0.380329073176888 719 708470 SGTC_112 phenothiazine 287.218 µM -0.307631274819543 0.398532443831736 no 2038 0.379181459833457 718 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_482 fipronil 114 µM -0.308907824477253 0.398047136961847 no 2039 0.378695822321659 663 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2807 7945238 51.95 µM -0.309699739138751 0.397746153358214 no 2040 0.378394650582563 707 17148797 SGTC_2457 5731572 11.68 µM -0.310362916462584 0.397494145863274 no 2041 0.378142495539314 704 2865357 SGTC_1327 1436-0082 2.18 µM -0.3109905424224 0.397255687289475 no 2042 0.377903905724733 686 15992205 SGTC_223 busulfan 5 mM -0.31440670806739 0.395958433709483 no 2043 0.376606080994351 686 2478 A DNA alkylator. SGTC_2893 9048488 25.97 µM -0.314817311795563 0.395802588424229 no 2044 0.376450183346807 671 6467338 SGTC_2595 hexamethylquercetagetin 100 µM -0.314984446888314 0.395739156807535 no 2045 0.376386731417028 725 386331 SGTC_1878 temozolomide 1 mM -0.316014187329329 0.395348407571207 no 2046 0.375995869803432 680 5394 DNA alkylating agent. SGTC_1620 st003704 16.5 µM -0.317190943330845 0.394902000060507 no 2047 0.375549360782825 652 2834414 SGTC_1733 st037357 54.9 µM -0.317878546969648 0.394641218435319 no 2048 0.375288533129421 716 1272339 YGL099W LSG1 SGTC_2666 tannic acid 100 µM -0.322213041853647 0.392998402351069 no 2049 0.373645652484327 686 16134267 A thiamine antagonist. SGTC_1562 morin hydrate 59.1 µM -0.322325359472176 0.392955858053955 no 2050 0.373603111689877 705 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1064 honokiol 6.76 µM -0.32303258791903 0.392687999491675 no 2051 0.373335281188405 686 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_817 1391-0715 46 µM -0.323329862281929 0.392575423759356 no 2052 0.373222720345131 709 1353946 SGTC_1360 1598-0022 39.8 µM -0.323520437220576 0.392503259083397 no 2053 0.373150566177452 713 761525 SGTC_960 1222-0186 7.7 µM -0.323647484250968 0.392455152461509 no 2054 0.373102466979022 709 3126296 SGTC_516 3992-2719 87.3 µM -0.323826556220056 0.392387349279087 no 2055 0.373034674827875 676 5350887 YDR037W KRS1 SGTC_2268 7933382 153.85 µM -0.324593583513074 0.392096961740525 no 2056 0.37274434205871 664 935025 YOR257W CDC31 SGTC_3247 9135149 49.47 µM -0.324906398142462 0.391978551030319 no 2057 0.372625957184629 699 8934436 YOR116C RPO31 SGTC_2757 clomiphene 4.22 µM -0.326453957912242 0.391392895709795 no 2058 0.37204045950752 694 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_3245 9134821 49.47 µM -0.327011095849565 0.391182113763098 no 2059 0.371829746461636 696 17014901 SGTC_1090 efavirenz 20.7 µM -0.327977082901854 0.390816727736018 no 2060 0.371464495138383 682 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1412 3909-8563 178 µM -0.328293370213102 0.390697112521942 no 2061 0.371344928230543 692 23767530 SGTC_353 1988-1175 58.3 µM -0.328361101653391 0.390671498830509 no 2062 0.371319325153075 711 2788357 SGTC_2839 9003951 25.97 µM -0.328384833851943 0.390662524244894 no 2063 0.371310354308935 711 2990634 SGTC_1096 rimcazole 32.2 µM -0.328912698023391 0.390462921806327 no 2064 0.371110838106085 702 18528119 A dopamine reuptake inhibitor. SGTC_412 gemfibrozil 100 µM -0.32929483754112 0.390318440560454 no 2065 0.370966422891081 674 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_725 1497-0963 19 µM -0.329298430308986 0.39031708226041 no 2066 0.370965065226194 695 3549977 SGTC_81 0411-0046 9.971 µM -0.329353035759757 0.390296438011527 no 2067 0.370944430663796 696 12925265 SGTC_3118 9124250 49.47 µM -0.329927324731903 0.390079339887787 no 2068 0.370727438154025 705 1504786 SGTC_1453 4237-0541 195 µM -0.330534536340845 0.389849833323377 no 2069 0.37049805068824 685 739892 SGTC_3239 9133757 49.47 µM -0.33114020228287 0.389620949222776 no 2070 0.370269292990707 702 17036923 SGTC_2044 5102272 200 µM -0.332898891562574 0.388956549218845 no 2071 0.369605303086069 682 592666 SGTC_2773 thioridazine 9.09 µM -0.334704004189921 0.388274948900752 no 2072 0.368924190301124 692 5452 An antipsychotic. SGTC_1171 0368-0077 21.4 µM -0.336376942186211 0.387643564003869 no 2073 0.368293317475757 679 3239779 SGTC_1514 1189-1591 158 µM -0.337486929778462 0.387224806472362 no 2074 0.36787493167606 737 767698 YMR146C TIF34 SGTC_1177 0983-0204 23.6 µM -0.338108132634882 0.386990506689769 no 2075 0.367640851063067 676 766818 SGTC_3021 9087658 49.47 µM -0.338118147890744 0.386986729561443 no 2076 0.367637077533698 694 25237042 SGTC_600 1495-0418 41.6 µM -0.33841912726517 0.386873223954691 no 2077 0.367523681051825 695 5377768 SGTC_2180 6301957 200 µM -0.338848378553088 0.386711361071299 no 2078 0.367361977044158 710 845462 SGTC_1746 st038117 42 µM -0.339059297328426 0.386631834640837 no 2079 0.367282530076833 687 2898218 SGTC_1383 3049-0032 20.7 µM -0.339778393283027 0.386360736997207 no 2080 0.367011710271186 717 712864 SGTC_1709 st033179 39.1045 µM -0.33996736419024 0.38628950456483 no 2081 0.366940552627329 687 573381 SGTC_758 0868-0029 16 µM -0.341067678509837 0.385874818155548 no 2082 0.366526316364553 666 762687 SGTC_2280 7785178 200 µM -0.341428892832874 0.385738712121783 no 2083 0.366390363568105 672 2954328 SGTC_1953 st076800 12.1 µM -0.343882853116065 0.384814429838245 no 2084 0.365467193787115 682 297591 SGTC_2525 harmine 47.85 µM -0.344210677956068 0.384691004283403 no 2085 0.365343926284021 696 5280953 A monoamine oxidase inhibitor SGTC_3072 9116419 49.47 µM -0.34428454307887 0.384663195789497 no 2086 0.365316153709015 701 17170162 SGTC_651 3253-0966 34.4 µM -0.344724262793146 0.384497663870667 no 2087 0.365150837951211 692 781462 SGTC_2601 securinine 100 µM -0.346247428243893 0.383924433191194 no 2088 0.364578386958966 687 442872 A GABA receptor antagonist. SGTC_3315 9136395 68.55 µM -0.348108450161617 0.383224397708878 no 2089 0.363879369224499 758 16876844 SGTC_210 3551-0445 56.827 µM -0.348387841280671 0.383119335773972 no 2090 0.363774466263804 727 2865180 YOR207C RET1 SGTC_197 4544-0043 41.561 µM -0.350198684624431 0.382438596944162 no 2091 0.363094796929658 694 896523 SGTC_2404 5161160 200 µM -0.350287288137362 0.382405298090553 no 2092 0.363061552145149 704 2831543 SGTC_166 k072-0058 166.424 µM -0.35119364961628 0.382064720515931 no 2093 0.362721536983961 720 5846229 SGTC_1134 3477-0009 42.5 µM -0.351673236397467 0.381884546196421 no 2094 0.362541667124469 714 3973534 SGTC_952 1185-0122 232 µM -0.353130864871963 0.381337091916782 no 2095 0.361995167375583 703 678600 SGTC_307 1501-1223 22.3 µM -0.354961472835568 0.380649890791305 no 2096 0.361309227203621 720 2830329 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.355438221879729 0.380470983261261 no 2097 0.361130659426607 733 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_355 1311-2252 105 µM -0.355787814945553 0.38033980924244 no 2098 0.360999737526647 697 5338538 SGTC_1988 st071872 53.4 µM -0.35745047992789 0.37971613405053 no 2099 0.360377295954953 699 16414116 SGTC_1546 5-methoxyflavanone 78.7 µM -0.35758513689244 0.379665637118991 no 2100 0.360326901431085 692 147795 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.358841268041226 0.379194681590515 no 2101 0.359856919232011 725 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_469 w7 172 µM -0.359593492330157 0.378912739325731 no 2102 0.359575575429153 686 45115570 A P450 inhibitor. SGTC_162 k030-0015 37.8 µM -0.359630521369009 0.37889886208089 no 2103 0.359561727945815 704 1809920 YMR134W ERG29 SGTC_2337 9009472 200 µM -0.360797431380076 0.37846162331183 no 2104 0.359125441557781 718 5742383 SGTC_259 usnic acid 108.925 µM -0.361736747979074 0.378109776300263 no 2105 0.358774381586121 746 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2748 diazoxide 86.69 µM -0.361907904922057 0.378045675610752 no 2106 0.358710426267143 684 3019 A potassium channel activatior. SGTC_1957 st077035 62.4 µM -0.362098670229888 0.377974235268164 no 2107 0.358639148661404 718 705593 SGTC_887 0885-0007 9.62 µM -0.362148512020293 0.377955570535654 no 2108 0.358620526571302 728 5719458 SGTC_2569 tetrandrine 100 µM -0.363274046368068 0.377534156844032 no 2109 0.358200089480465 686 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1484 3473-2379 286 µM -0.363665864913838 0.377387489410527 no 2110 0.358053768150115 705 671917 SGTC_2992 9074591 71.4286 µM -0.364328550096451 0.377139470106332 no 2111 0.357806341417805 720 17741321 SGTC_390 dec-rvkr-cmk 16.7 µM -0.364446311886301 0.377095401390541 no 2112 0.357762378951983 696 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_787 4152-0075 138 µM -0.364617549181323 0.37703132397351 no 2113 0.357698456543124 678 9566539 SGTC_740 k014-0057 261 µM -0.364810592030989 0.376959090925016 no 2114 0.357626398966696 722 4012779 SGTC_12 0849-0099 9.267 µM -0.365736203303935 0.376612804244576 no 2115 0.357280964322202 716 6071388 SGTC_1856 st057054 55.7 µM -0.365991267354123 0.376517397944828 no 2116 0.357185795916022 735 1266018 SGTC_1485 3909-9022 254 µM -0.366972971960757 0.376150263338068 no 2117 0.356819589440461 711 714516 SGTC_1981 st071826 47 µM -0.36716494711576 0.376078482199203 no 2118 0.356747992122289 689 11838600 SGTC_3228 9131799 49.47 µM -0.367419500816771 0.375983309022394 no 2119 0.356653063857845 703 17015818 SGTC_3006 9075424 71.4286 µM -0.367523605019882 0.375944388454402 no 2120 0.356614243835793 708 7465181 SGTC_1885 st057546 99.9 µM -0.369714985009048 0.375125408969043 no 2121 0.355797432652813 700 702008 SGTC_2625 euphol 100 µM -0.370071264347489 0.374992310575996 no 2122 0.355664696136611 701 6708538 A triterpene alcohol. SGTC_1322 1348-1070 12 µM -0.370782344491262 0.374726710655339 no 2123 0.355399826283994 716 6758089 SGTC_793 0488-0545 106 µM -0.370796459786687 0.374721438965477 no 2124 0.355394569191754 697 292548 SGTC_3211 9128781 49.47 µM -0.370868203186303 0.374694645063371 no 2125 0.355367849547986 716 17194361 SGTC_176 1486-1328 72.834 µM -0.371353069091674 0.374513578771046 no 2126 0.355187287897182 686 22310231 SGTC_1609 st001574 46.4 µM -0.372052908272717 0.374252282555919 no 2127 0.354926728600791 724 3960012 SGTC_3337 9144342 33.5465 µM -0.372176937773092 0.374205980168204 no 2128 0.354880557865975 679 17682949 SGTC_1091 telmisartan 47.6 µM -0.373036376210135 0.373885186609669 no 2129 0.35456068527105 732 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1545 lovastatin 49.4 µM -0.374169180181584 0.373462490218254 no 2130 0.35413922600528 689 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_206 4546-0025 72.014 µM -0.375761499195761 0.372868587034005 no 2131 0.353547106426814 746 6620745 YIL048W NEO1 SGTC_587 k089-0003 57 µM -0.37599000984009 0.372783381878772 no 2132 0.353462161513626 694 9659696 SGTC_1897 st060201 15 µM -0.37666145998751 0.372533053139296 no 2133 0.353212603678143 703 611878 SGTC_305 1682-2595 20.8 µM -0.379184033855463 0.371593073900172 no 2134 0.352275603498808 722 226033 SGTC_2220 6782180 200 µM -0.379284753083678 0.371555559040101 no 2135 0.35223821030026 714 833803 SGTC_2904 7225135 42.03 µM -0.379330037669401 0.371538692301862 no 2136 0.352221398330471 732 4446116 SGTC_732 3970-1727 52.7 µM -0.37976856486457 0.371375370824501 no 2137 0.352058609400683 730 1275699 SGTC_557 1315-0110 16.2 µM -0.380047046528095 0.371271667414126 no 2138 0.351955246230515 708 6833801 SGTC_1643 st009866 20.2 µM -0.380578508282976 0.371073783030439 no 2139 0.351758015593417 712 3156273 YOR207C RET1 SGTC_1901 st060216 58.6 µM -0.380621148086903 0.371057908009124 no 2140 0.351742193274489 695 688792 SGTC_645 0845-0943 5.41 µM -0.381704137009609 0.37065477921603 no 2141 0.351340415569264 707 1885106 SGTC_2986 9022445 71.43 µM -0.382176711197238 0.370478913974686 no 2142 0.351165147441411 747 6459286 SGTC_661 1304-0007 33.6 µM -0.382288766007912 0.370437217514021 no 2143 0.351123593238647 696 3117130 SGTC_421 streptovitacin 30 mM -0.382904755118558 0.370208030401991 no 2144 0.350895192754262 725 91467 include heat shock SGTC_532 1548-0774 215 µM -0.382970468923936 0.370183583406849 no 2145 0.350870830136703 757 5932993 SGTC_942 3253-1115 227 µM -0.383708025889597 0.369909231830227 no 2146 0.35059743167849 746 46497897 SGTC_3339 9145883 14.936 µM -0.383895490760821 0.369839510428651 no 2147 0.350527954311474 740 2030670 SGTC_1391 3442-0225 151 µM -0.385625716373703 0.369196212083661 no 2148 0.349886942367203 676 5227075 SGTC_912 3474-0017 2.18 µM -0.385798563154067 0.369131967691021 no 2149 0.349822929758318 746 3360550 SGTC_2558 carylophyllene oxide 100 µM -0.386416375902296 0.368902366436441 no 2150 0.349594161989415 737 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2186 6124449 200 µM -0.386835375111531 0.36874667799891 no 2151 0.349439043277141 705 3834182 YLR033W RSC58 SGTC_595 3909-8003 73.7 µM -0.387438553180002 0.368522591652704 no 2152 0.349215783414398 733 699517 SGTC_2336 9001819 198.65 µM -0.388259672408853 0.368217609974176 no 2153 0.348911938841097 733 2989602 SGTC_1908 st060353 56.5 µM -0.389215778147825 0.367862595978285 no 2154 0.34855826630792 758 4227716 SGTC_805 3852-0218 479 µM -0.389717261075306 0.367676434205436 no 2155 0.348372815634192 720 6615355 SGTC_25 0118-0223 35.662 µM -0.391375092986434 0.367061231066689 no 2156 0.347759999981133 727 5333628 SGTC_1561 5-methoxyflavone 52.9 µM -0.392034928788963 0.366816468112524 no 2157 0.347516202944106 709 94525 SGTC_2148 5546263 113.568 µM -0.393068119496968 0.366433319716342 no 2158 0.34713458492918 702 792097 SGTC_53 0973-0023 39.979 µM -0.394913974024741 0.365749134602434 no 2159 0.346453188351768 734 674768 SGTC_1818 st052136 56.3 µM -0.395049345875577 0.365698974395539 no 2160 0.346403235397251 710 674169 SGTC_2129 girgensonine 121.053 µM -0.39512344227936 0.365671519948436 no 2161 0.346375894549559 726 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3352 9151559 45.5865 µM -0.395917902399939 0.365377197194996 no 2162 0.346082796869107 694 17159339 SGTC_2478 5763493 32.33 µM -0.400298707257749 0.363755673111382 no 2163 0.344468259999185 692 1365576 YLR208W SEC13 SGTC_1223 0764-0573 147 µM -0.401649149495611 0.363256306505599 no 2164 0.343971126421086 698 1609797 SGTC_39 0986-0283 58.349 µM -0.401659820972729 0.363252361330321 no 2165 0.343967199040067 700 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2876 9059903 25.97 µM -0.401815908465252 0.363194658463548 no 2166 0.343909756708831 724 6916095 SGTC_2115 tiliquinol 12.7705 µM -0.407677885585126 0.361029844554462 no 2167 0.341755087562472 755 71208 A bioactive hydroxyquinoline. SGTC_2491 paeonol 100 µM -0.408306236275706 0.360798058666776 no 2168 0.341524430708078 735 11092 Increases levels of cortical cytochrome oxidase. SGTC_1684 st024538 14.6195 µM -0.409582001846474 0.360327611838123 no 2169 0.341056300963677 713 6732859 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.409687005064559 0.36028890062638 no 2170 0.341017781939593 722 368090 SGTC_2911 7942208 15.64 µM -0.4098191201091 0.360240196216214 no 2171 0.340969319659147 714 1243384 SGTC_2894 9048625 32.47 µM -0.410436756306603 0.360012533800772 no 2172 0.340742793915338 747 4092861 SGTC_543 3844-1095 191 µM -0.412397591269465 0.359290093936372 no 2173 0.340024014187852 735 4230703 SGTC_1440 4100-1550 40 µM -0.414039069609615 0.358685702640741 no 2174 0.339422747112309 729 742806 SGTC_2419 paclitaxel 166.5 µM -0.414409513779999 0.358549354194692 no 2175 0.339287111315857 734 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2164 5685496 200 µM -0.414441646821052 0.358537527917294 no 2176 0.339275346986668 721 759046 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.415863713514803 0.358014285030526 no 2177 0.338754866689452 745 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1072 oxiconazole 14.9 nM -0.416912529890461 0.357628548641355 no 2178 0.338371194144605 710 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2587 piperic acid 92.2 µM -0.417503841735379 0.357411138505908 no 2179 0.338154957441752 721 5370536 SGTC_1225 1216-0074 20.6 µM -0.420137278014483 0.356443454603468 no 2180 0.337192585759445 724 4241466 SGTC_3227 9130768 49.47 µM -0.420303120797286 0.356382544772832 no 2181 0.337132015184942 735 17720899 SGTC_889 0919-1524 82.7 µM -0.420513248691757 0.356305375410071 no 2182 0.337055276472153 729 3905452 SGTC_1214 0358-0031 63.7 µM -0.422215352743101 0.355680495680332 no 2183 0.33643391818185 759 4301366 SGTC_1803 st050068 52.4 µM -0.422234990947043 0.355673288323795 no 2184 0.336426751797385 728 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2862 9027634 71.43 µM -0.422310239525867 0.355645672053098 no 2185 0.336399292593635 710 5012562 SGTC_828 2074-0507 139 µM -0.4230120305069 0.355388150872226 no 2186 0.336143241798246 718 X828 SGTC_1075 aripiprazole 15.2 µM -0.42571245487989 0.354397850707871 no 2187 0.335158692692229 729 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2855 9016525 58.44 µM -0.426033479003542 0.354280189962855 no 2188 0.335041725458361 714 43811474 SGTC_2306 7482397 179.52 µM -0.428259959055344 0.353464530831659 no 2189 0.334230933656445 766 891448 SGTC_3319 9138450 16.7555 µM -0.428294036995097 0.353452051775396 no 2190 0.334218529878241 738 2029690 SGTC_2861 9024595 19.48 µM -0.429461638383963 0.353024581164113 no 2191 0.33379365269392 708 16482810 SGTC_2899 9053889 58.44 µM -0.429596479816698 0.35297522629292 no 2192 0.333744599103838 744 6470052 SGTC_1497 4476-2978 41.3 µM -0.429761015540147 0.352915006021927 no 2193 0.333684746959301 742 1528379 SGTC_1246 0422-0085 105 µM -0.430542641907572 0.352628980186548 no 2194 0.333400477387761 755 264295 SGTC_660 4031-1742 102 µM -0.430998637441961 0.3524621531097 no 2195 0.333234680610634 718 6738706 SGTC_1141 3253-0389 52.6 µM -0.431261554101667 0.352365977305039 no 2196 0.333139100764492 761 5402031 SGTC_1156 4092-0367 4.88 µM -0.433838631956089 0.351423774055691 no 2197 0.332202812998228 737 1357585 SGTC_919 tnp00227 403.569 nM -0.435225375937081 0.350917144881159 no 2198 0.331699422509164 747 1269246 A methoxyflavone. YNL221C POP1 SGTC_2171 5739187 198.077 µM -0.435935560237783 0.350657790652045 no 2199 0.331441741919731 712 2262761 SGTC_935 2996-0153 430 µM -0.436899599819797 0.350305841651196 no 2200 0.331092081086299 752 23738523 SGTC_1341 1486-1360 280 µM -0.437686679557253 0.350018591945693 no 2201 0.330806713432446 756 3976547 SGTC_3162 9099653 49.47 µM -0.438624348950404 0.349676495600972 no 2202 0.33046687553306 718 25237511 SGTC_2415 st077333 57.7 µM -0.439001757796466 0.349538837373279 no 2203 0.330330131324991 755 2766255 SGTC_1094 duloxetine 25.4 µM -0.439781782337759 0.34925438954613 no 2204 0.33004758168133 716 60834 A selective serotonin reuptake inhibitor. SGTC_1631 benzylvanillin 81.9 µM -0.439794576319541 0.349249724731064 no 2205 0.330042948102511 733 75506 SGTC_1148 3909-7663 27.7 µM -0.440271688463777 0.349075781086879 no 2206 0.329870171672474 763 4084526 SGTC_1833 st055984 71 µM -0.440842919275626 0.348867565738864 no 2207 0.329663359823303 712 676288 SGTC_1978 st071761 42 µM -0.44098812367732 0.348814645549033 no 2208 0.329610797444383 708 5147680 SGTC_159 3970-0959 50 µM -0.441642065015675 0.348576351083021 no 2209 0.329374119674107 721 6615653 SGTC_405 ebelactone b 50 µM -0.441676257488577 0.348563893080412 no 2210 0.329361746440138 736 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2451 5856223 45.7 µM -0.441772870308637 0.348528693152504 no 2211 0.329326786158158 726 2179896 SGTC_1370 2001-0092 44.6 µM -0.442255349674145 0.348352926080395 no 2212 0.329152218677356 749 790957 SGTC_1857 st056007 79.3 µM -0.444923365803439 0.34738155745614 no 2213 0.32818756811724 731 619834 SGTC_1552 6-methylflavone 10.6 µM -0.44582148011731 0.347054797885846 no 2214 0.327863102199424 757 689013 SGTC_2602 kawain 100 µM -0.445877734551913 0.347034334701153 no 2215 0.327842783219805 739 5369129 SGTC_1163 k060-0048 49.9 µM -0.446398490777806 0.346844924937962 no 2216 0.327654711404601 712 6809982 SGTC_1650 st011916 45.8 µM -0.446490153850564 0.346811589150274 no 2217 0.3276216116853 763 242528 SGTC_1161 k007-0610 110 µM -0.447471977763675 0.346454596409249 no 2218 0.327267158111191 759 5843850 SGTC_142 0335-0849 62.6745 µM -0.448495076825263 0.346082741014795 no 2219 0.326897969222245 716 3889043 YPR107C YTH1 SGTC_659 k018-0002 107 µM -0.449759421941205 0.345623407364127 no 2220 0.326441959858989 741 6797879 YHR007C ERG11 SGTC_2755 lomerizine 42.69 µM -0.45135798273302 0.345042979192182 no 2221 0.325865780610186 732 3949 A calcium channel blocker. SGTC_1973 st070275 50.2 µM -0.451430118561283 0.345016795673203 no 2222 0.325839790034009 742 17118334 SGTC_124 0136-0217 7.121 µM -0.452867659862498 0.344495158674625 no 2223 0.325322019793446 763 3976905 SGTC_2819 7996655 46.38 µM -0.453613930363646 0.344224477867353 no 2224 0.325053362658394 733 6456960 SGTC_850 0388-0143 75.9 µM -0.454962653415243 0.343735483126949 no 2225 0.324568053553959 736 67273 SGTC_2381 9035592 200 µM -0.458228486297866 0.342552502452323 no 2226 0.323394148103119 748 4749657 SGTC_106 0092-0003 11.579 µM -0.458551409253991 0.342435613891142 no 2227 0.323278168474528 744 1072148 SGTC_1092 toremifene 6.32 µM -0.458555797287021 0.342434025656835 no 2228 0.32327659260558 775 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1924 st058459 75.1 µM -0.459439764250799 0.342114133535177 no 2229 0.32295919932097 734 688683 SGTC_2194 5927483 104.545 µM -0.46048934947143 0.341734454188884 no 2230 0.322582507248064 712 760979 SGTC_842 0271-0008 11.1 µM -0.460815885538253 0.341616364912383 no 2231 0.322465351825188 745 1221709 SGTC_3010 9080089 71.4286 µM -0.461229031851214 0.341466975914632 no 2232 0.322317147424543 750 17027233 SGTC_2118 5526350 200 µM -0.461716782743452 0.341290642717768 no 2233 0.3221422171181 750 743594 SGTC_777 1315-0167 517 µM -0.462343746970359 0.341064031584208 no 2234 0.321917416255383 719 4221767 SGTC_2395 5646831 180.19 µM -0.464140487866099 0.340414931904907 no 2235 0.321273547814599 786 6808628 SGTC_3165 9101544 49.47 µM -0.464857631715994 0.340155984716043 no 2236 0.321016706559487 749 5002184 SGTC_1522 st012842 45.6 µM -0.465239799222154 0.340018021976814 no 2237 0.320879870259818 765 3491067 YOR116C RPO31 SGTC_1865 st057639 52.2 µM -0.465435973724759 0.339947211161616 no 2238 0.320809638798765 735 688818 SGTC_1218 1348-1416 30.7 µM -0.46897227032839 0.338671725934545 no 2239 0.319544728466567 743 6787668 SGTC_462 ag-879 158 µM -0.469321590167082 0.338545831951946 no 2240 0.319419892577466 760 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.46946732428453 0.33849331507857 no 2241 0.319367817850921 723 688664 SGTC_617 3770-0098 35 µM -0.471212833420582 0.337864546236722 no 2242 0.318744377536646 763 5962639 SGTC_1954 st077032 68.9 µM -0.472698379661913 0.337329777518898 no 2243 0.318214191386838 781 698907 SGTC_1648 st011736 69.8 µM -0.474222117429542 0.336781601763381 no 2244 0.317670761474982 746 2855514 SGTC_2257 7960413 200 µM -0.474937377224854 0.336524401294351 no 2245 0.317415804626607 740 2974689 YIL048W NEO1 SGTC_768 0384-0033 77.3 µM -0.476582125162723 0.335933256167633 no 2246 0.316829857163965 759 3965305 YMR134W ERG29 SGTC_322 k048-0136 19.3 µM -0.476843899049503 0.335839208397304 no 2247 0.31673664157976 741 6823282 SGTC_2704 st078022 71.1 µM -0.47717623071424 0.335719826071489 no 2248 0.316618317698295 775 54697681 SGTC_2611 pyromycin 23.93 µM -0.477445347794649 0.335623164243775 no 2249 0.316522514583519 734 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_3268 9137683 49.47 µM -0.479348129948621 0.334940031075845 no 2250 0.315845493769946 783 1953228 SGTC_1132 3456-3614 2.5 µM -0.479678374252563 0.334821522923153 no 2251 0.315728053756499 763 3125502 SGTC_1526 st051518 75 µM -0.479685076391857 0.334819118031041 no 2252 0.315725670564033 744 673993 SGTC_2008 4012253 172 µM -0.480157139248983 0.334649747336726 no 2253 0.315557830508859 726 603940 SGTC_1644 st010134 20.9 µM -0.481721834068531 0.334088593625566 no 2254 0.315001781701209 779 3818134 SGTC_2961 9083290 32.55 µM -0.483914006497374 0.333303028393496 no 2255 0.314223449794172 768 17741490 SGTC_1291 0993-0025 5.79 µM -0.484402389431184 0.333128115714978 no 2256 0.314050161494871 742 4353356 SGTC_687 k029-0044 34.9 µM -0.484882985153778 0.332956027427552 no 2257 0.313879676273399 764 5829338 SGTC_1512 0259-0544 12.2 µM -0.485275686191149 0.332815437954066 no 2258 0.313740400063338 722 18476 SGTC_2097 5376186 200 µM -0.487584072323153 0.331989496695716 no 2259 0.312922239832384 735 742755 SGTC_2172 5754775 163.918 µM -0.488070011125112 0.331815731441464 no 2260 0.312750125919458 737 2263357 SGTC_374 0880-0231 82.3 µM -0.488206101634795 0.331767073767261 no 2261 0.31270193154692 748 6833587 SGTC_2720 fluspirilene 36.88 µM -0.4885098070405 0.331658497453325 no 2262 0.312594390469569 765 3396 An atypical antipsychotic. SGTC_111 0083-0039 52.457 µM -0.488561740341202 0.331639932434945 no 2263 0.31257600265705 761 759313 SGTC_2166 5933061 31.504 µM -0.488940288017385 0.331504622421107 no 2264 0.312441985917908 737 2877375 SGTC_2048 5246248 200 µM -0.489739788459326 0.331218917176183 no 2265 0.312159021348017 745 677046 SGTC_1301 naphtanilide LB 4.81 µM -0.489774218881383 0.33120661550779 no 2266 0.312146837988568 764 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1290 0986-0249 10.2 µM -0.490027348146386 0.331116180377843 no 2267 0.312057273369723 763 53329 SGTC_696 1560-0013 611 µM -0.4901417670391 0.331075305336363 no 2268 0.312016792227522 748 1650269 SGTC_711 k292-0785 179 µM -0.492438525415592 0.330255236995202 no 2269 0.311204685067104 757 4146315 SGTC_2179 6298986 200 µM -0.493906124076771 0.329731650338379 no 2270 0.310686239672394 755 738374 SGTC_2824 7998404 51.95 µM -0.496464319461413 0.328819775588575 no 2271 0.30978342759725 785 837851 SGTC_535 2293-4129 48.2 µM -0.497336118436677 0.328509253111169 no 2272 0.309476022813324 791 396118 YIL048W NEO1 SGTC_2689 tacrolimus 100 µM -0.497911734853514 0.328304291558781 no 2273 0.309273127902142 769 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2642 cholecalciferol 100 µM -0.498484770399409 0.328100300305816 no 2274 0.309071200455759 775 9821465 A vitamin D precursor, similar to steriods. SGTC_1965 Pectolinarigenin 58.4 µM -0.498969461503711 0.327927798235705 no 2275 0.308900449024428 764 5320438 An anti-inflammatory. SGTC_820 1582-0060 59.9 µM -0.499720683307585 0.327660510148677 no 2276 0.308635883314455 761 3848840 SGTC_2902 5787006 60.46 µM -0.499975693608565 0.327569796405076 no 2277 0.308546096215629 755 591003 SGTC_937 3122-0005 46.7 µM -0.501205705382131 0.32713239250313 no 2278 0.308113179695322 777 759535 SGTC_1432 4049-0298 68.4 µM -0.501415865035272 0.327057681451021 no 2279 0.308039238308553 775 741646 SGTC_1401 3807-4679 7.6 µM -0.501644311110798 0.326976477498006 no 2280 0.307958871967918 770 3291456 SGTC_1618 st003135 44.5 µM -0.502014658945505 0.326844850234676 no 2281 0.307828604770697 789 1270615 SGTC_1288 0973-0013 65.5 µM -0.504325543565391 0.326024013792381 no 2282 0.307016315186179 756 4315430 SGTC_3332 9141069 11.198 µM -0.505049599811322 0.325766998928758 no 2283 0.306761999652375 751 17332883 SGTC_330 1488-0319 80.1 µM -0.507683328864066 0.324832815420365 no 2284 0.305837720845224 753 6846614 SGTC_2267 7931562 200 µM -0.509244626432691 0.324279542440443 no 2285 0.305290383072381 738 934880 SGTC_1765 st044815 90.4 µM -0.509778289055394 0.324090518655837 no 2286 0.305103398831147 760 645695 SGTC_2380 9035439 200 µM -0.510049951386037 0.323994313023882 no 2287 0.305008233555549 751 6462575 SGTC_1052 3253-3998 198 µM -0.510185997574157 0.32394613847725 no 2288 0.30496058054832 751 5450317 SGTC_2203 7227154 166.4 µM -0.514132917941784 0.322549803237556 no 2289 0.303579532102663 746 896304 SGTC_776 4476-4378 112 µM -0.514961979872332 0.322256815979829 no 2290 0.303289794190086 795 2892008 SGTC_1852 st056254 31.4 µM -0.516298288603808 0.321784802104185 no 2291 0.302823045671586 762 442583 SGTC_548 1436-0017 110 µM -0.516656666213028 0.321658264038601 no 2292 0.302697925559151 778 9677137 SGTC_2435 5706476 10.6 µM -0.517149926164236 0.321484134756954 no 2293 0.302525751959169 755 5725375 SGTC_3279 9140807 49.47 µM -0.517218531366496 0.3214599190417 no 2294 0.302501808622423 774 45595718 SGTC_3321 9137793 26.8275 µM -0.517422012498738 0.321388100363079 no 2295 0.302430798345072 745 4904192 SGTC_1499 4480-0877 67.3 µM -0.51760289106827 0.32132426486612 no 2296 0.302367682123326 754 2861909 SGTC_444 curcumin 90.4 µM -0.518673594304776 0.320946501412785 no 2297 0.301994189313144 760 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_812 4251-0442 148 µM -0.519150529663075 0.320778289619741 no 2298 0.301827886955967 774 5723007 SGTC_790 1575-0012 79.1 µM -0.519194220355511 0.320762882054489 no 2299 0.301812654527898 775 378741 YLR208W SEC13 SGTC_1929 genistein trimethyl ether 50.5 µM -0.519214451048604 0.320755747785439 no 2300 0.301805601367449 767 136420 SGTC_2937 9044753 11.33 µM -0.520429388797072 0.320327426527914 no 2301 0.301382165475314 726 6465530 YGL099W LSG1 SGTC_2703 st077852 53.4 µM -0.520780008169263 0.320203861585032 no 2302 0.301260015687285 784 6281836 SGTC_1605 st000082 49.1 µM -0.524251005258762 0.318981693510361 no 2303 0.300051984673507 765 1114022 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.525115952006792 0.318677443676087 no 2304 0.299751293718457 810 65057 A dermal irritant. YDR527W RBA50 SGTC_336 4111-0029 111 µM -0.525260064097555 0.318626763316025 no 2305 0.299701207712387 780 3131175 SGTC_246 cycloheximide 667 µM -0.525708616216201 0.318469041274595 no 2306 0.299545338161344 762 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_80 0159-0065 512.242 µM -0.525726181564208 0.318462865531995 no 2307 0.299539235040995 736 1548079 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.52589976631927 0.31840183815465 no 2308 0.299478925651416 752 4330530 SGTC_3252 9135871 49.47 µM -0.528577081136909 0.317461196661644 no 2309 0.298549431317836 777 17682838 SGTC_1479 0549-0158 134 µM -0.529502280686065 0.317136412674757 no 2310 0.298228531367874 762 5440202 SGTC_2970 9090938 41.86 µM -0.531179534767086 0.31654798501214 no 2311 0.297647186647769 732 17217104 SGTC_581 0958-0271 211 µM -0.531757030869878 0.316345490531157 no 2312 0.297447143339797 764 4591145 SGTC_956 1185-0240 191 µM -0.532051237522185 0.316242350439375 no 2313 0.297345254452464 761 1416193 SGTC_3094 9117742 49.47 µM -0.532204821662909 0.316188514091472 no 2314 0.297292071925013 813 17149698 SGTC_526 4469-0568 170 µM -0.532330899642782 0.31614432247973 no 2315 0.297248417374277 756 2901964 SGTC_2949 9072542 2.23 µM -0.53380404825343 0.315628163702874 no 2316 0.296738556324422 794 16457352 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.534458167422723 0.315399089947896 no 2317 0.296512292205485 799 688801 SGTC_773 4358-1457 44.6 µM -0.53525415001049 0.315120431043037 no 2318 0.296237063281114 805 1186886 SGTC_1153 4055-0057 267 µM -0.535428604438923 0.315059371793491 no 2319 0.29617675738834 772 882706 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.535455072520479 0.315050108376119 no 2320 0.296167608320277 771 4174840 SGTC_1155 4088-0394 48.2 µM -0.535965057491135 0.314871644277704 no 2321 0.295991350100405 771 2326248 SGTC_1417 3966-0327 90.4 µM -0.539945438017938 0.313480237987145 no 2322 0.294617330446463 775 651118 SGTC_1881 5652484 16 µM -0.542821652169161 0.31247645870489 no 2323 0.293626301910303 791 2255129 SGTC_1059 3448-6867 171 µM -0.545104379159511 0.311680791062139 no 2324 0.292840865509135 783 3934407 SGTC_3078 9116413 49.47 µM -0.545790237578868 0.311441899589753 no 2325 0.292605067324206 764 17177322 SGTC_830 4076-0286 57.8 µM -0.54589979622547 0.311403746546511 no 2326 0.292567409224359 772 6866659 SGTC_2317 5986382 200 µM -0.546021498048656 0.31136136710038 no 2327 0.292525579845627 803 877883 SGTC_280 3448-3607 3.04 µM -0.546888196851754 0.311059634445953 no 2328 0.292227772582318 779 626179 SGTC_593 1203-0218 61.7 µM -0.547239333237271 0.31093742589477 no 2329 0.292107158410007 790 3666956 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.547305841179602 0.310914280999649 no 2330 0.292084315764671 795 91467 include heat shock SGTC_78 0336-0123 156.75 µM -0.548365803049868 0.31054551318366 no 2331 0.291720376279223 772 6765896 SGTC_1279 0874-0590 65.2 µM -0.548427483159264 0.310524060117449 no 2332 0.291699204830186 775 3523074 SGTC_2844 9010103 25.97 µM -0.54925932127006 0.310234800030563 no 2333 0.291413749729811 811 2480525 SGTC_3234 9132280 49.47 µM -0.550534005434957 0.309791774164162 no 2334 0.290976579805435 771 17612295 SGTC_281 1672-3440 14.9 µM -0.553339487512968 0.308817681502904 no 2335 0.290015483305872 781 6833000 SGTC_3111 9122088 49.47 µM -0.55375561092768 0.308673313350541 no 2336 0.289873055406348 773 16876704 SGTC_3249 9135183 49.47 µM -0.554398162085761 0.308450447364665 no 2337 0.289653191819586 767 4902779 SGTC_2474 5321570 43.32 µM -0.55479301059845 0.308313530927867 no 2338 0.289518124203997 788 2841384 SGTC_154 3389-1638 511.116 µM -0.556623060057183 0.307679297073404 no 2339 0.288892497463437 818 5238686 SGTC_2718 lomofungin 53.02 µM -0.557558685268841 0.307355262454214 no 2340 0.288572887527257 793 5351222 A RNA synthesis inhibitor. SGTC_1286 0929-0070 131 µM -0.560788510426884 0.306237834972034 no 2341 0.287470860080303 788 1420408 SGTC_1389 3405-0187 19 µM -0.561509551320595 0.305988620781244 no 2342 0.287225110466321 778 799890 SGTC_2537 larixol 68.93 µM -0.562137467435677 0.305771666546463 no 2343 0.287011181246771 769 6708759 SGTC_1408 3909-7976 48.8 µM -0.563096358703798 0.305440487055222 no 2344 0.286684635440691 775 24152374 SGTC_3324 9138759 60.749 µM -0.564373385858141 0.30499967771819 no 2345 0.286250023719597 783 45595710 SGTC_439 amiodarone 34.4 µM -0.566288242639444 0.304339229864665 no 2346 0.285598925823415 776 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_273 hydroxyurea 18.1 mM -0.568455517130089 0.303592490549065 no 2347 0.284862851150711 812 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_403 arphamenine a 50 µM -0.569554620568732 0.303214104886682 no 2348 0.28448990720855 791 5487158 An arginine aminopeptidase inhibitor. SGTC_3154 9100113 49.47 µM -0.570859976103601 0.302764987468035 no 2349 0.28404728174376 790 25237525 SGTC_1284 0929-0043 16 µM -0.571778548677694 0.302449124355645 no 2350 0.283736005890015 785 1239883 SGTC_929 2805-0021 398 µM -0.572419385095153 0.302228851968066 no 2351 0.28351894301315 819 3098024 SGTC_1455 4262-0120 131 µM -0.573416268238781 0.301886340109422 no 2352 0.283181438940949 779 1529587 SGTC_2091 4-phenylthiadiazole 200 µM -0.574049600946305 0.301668828557189 no 2353 0.282967118431169 796 270010 SGTC_2388 9080168 200 µM -0.574215566836104 0.30161184094921 no 2354 0.282910968265133 800 15943073 SGTC_2960 9079389 5.97 µM -0.575938669501517 0.301020466568145 no 2355 0.282328318442797 778 16457355 SGTC_2620 irigenin 100 µM -0.576062950380071 0.300977833186689 no 2356 0.282286316446271 800 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2877 9040724 71.43 µM -0.576549171579755 0.300811065761954 no 2357 0.282122021907356 785 6463895 SGTC_2874 9043904 71.43 µM -0.577570866264898 0.30046077393277 no 2358 0.281776940522041 785 4463428 SGTC_1870 st057514 26.5 µM -0.578650959927613 0.300090660284787 no 2359 0.281412356017445 784 5393161 SGTC_1158 4092-0494 91.8 µM -0.579610079133269 0.29976217369787 no 2360 0.281088797258928 783 1148199 SGTC_1459 k035-0031 35.7 µM -0.580830117627582 0.299344560925315 no 2361 0.280677477286093 789 3877128 YMR208W ERG12 SGTC_1859 st055998 20 µM -0.582277472289462 0.298849481520902 no 2362 0.280189898544349 800 676301 SGTC_491 tetrandrine 80.3 µM -0.583323374122153 0.298491954043119 no 2363 0.279837815151137 799 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3230 9131665 49.47 µM -0.583932390070636 0.298283859817914 no 2364 0.279632900171512 786 15943720 SGTC_2289 7946404 165.07 µM -0.583963481311624 0.298273238046284 no 2365 0.279622440887457 776 1246120 YPR165W RHO1 SGTC_2880 9042983 58.44 µM -0.584877528643728 0.29796104695731 no 2366 0.279315034645565 810 6464714 SGTC_2355 9061122 103.12 µM -0.585826410129236 0.297637115994444 no 2367 0.278996087026622 803 5302957 SGTC_1281 0884-0031 11.8 µM -0.585919628770099 0.297605301509734 no 2368 0.278964762995199 800 1548255 SGTC_356 1634-0012 32.5 µM -0.586641604963996 0.297358951650041 no 2369 0.278722217054749 808 735457 SGTC_1701 st028638 40.4 µM -0.586747026325894 0.297322987985933 no 2370 0.278686809626112 790 3490878 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.586883204742556 0.297276534737533 no 2371 0.278641075196861 829 6728940 SGTC_555 4296-0685 37 µM -0.58702271690296 0.297228947720448 no 2372 0.278594224946808 811 2908540 YHR072W ERG7 SGTC_996 3970-0799 1.8 µM -0.590075496205341 0.296188530204188 no 2373 0.277570017992568 782 6615648 YGL040C HEM2 SGTC_950 1165-0508 94.1 µM -0.590204658226437 0.296144547365836 no 2374 0.27752672475681 781 6148369 SGTC_26 0302-0163 425.158 µM -0.591052861703877 0.295855787748927 no 2375 0.277242501274559 822 3100915 SGTC_277 nystatin 15.5 µM -0.591349213726194 0.29575492912907 no 2376 0.27714323060621 804 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1842 st055362 61.2 µM -0.59215703828456 0.295480079357027 no 2377 0.276872717520732 766 676032 SGTC_829 1635-0120 117 µM -0.592287592878698 0.295435671210861 no 2378 0.276829011349251 802 285054 SGTC_926 2268-1401 59.4 µM -0.59248077439706 0.295369966148827 no 2379 0.276764345565832 800 2931578 SGTC_1345 1488-0192 31.4 µM -0.592552008421108 0.295345739668858 no 2380 0.276740502481749 797 658348 SGTC_620 0109-0052 432 µM -0.593104924790933 0.295157725553268 no 2381 0.276555467402764 811 493037 SGTC_2305 7443522 69.23 µM -0.594800889495099 0.294581372436322 no 2382 0.275988286465485 792 5415886 SGTC_2378 9074213 121.43 µM -0.594894533964447 0.29454956362742 no 2383 0.275956985625398 792 657714 SGTC_2143 5623677 140.463 µM -0.595505786916558 0.294341974419958 no 2384 0.275752716020968 779 5375313 SGTC_1178 0988-0033 191 µM -0.598126549115002 0.293452697282249 no 2385 0.27487774831061 783 5392207 SGTC_2214 7179297 48.276 µM -0.598147588555922 0.29344556321661 no 2386 0.274870729622613 776 769744 SGTC_2393 9031399 185.94 µM -0.599239756228063 0.29307534076341 no 2387 0.274506507441659 815 1526623 YDL150W RPC53 SGTC_2869 9037858 32.47 µM -0.599405594867511 0.293019143815751 no 2388 0.274451223477058 782 27187042 SGTC_2455 5377712 9.75 µM -0.600171033261696 0.292759828172979 no 2389 0.274196128183825 775 2243908 SGTC_3092 9117248 49.47 µM -0.600776257909085 0.292554865303384 no 2390 0.273994509771174 811 17141857 SGTC_1707 st032323 6.317 µM -0.602474352450041 0.291980151945472 no 2391 0.273429215217423 795 3132057 YMR211W DML1 SGTC_1230 0170-0365 3.77 µM -0.603904960532581 0.291496376698456 no 2392 0.272953415312944 798 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1299 1079-1439 3.74 µM -0.60433735166169 0.291350232673867 no 2393 0.272809689005788 804 323161 SGTC_1703 st026983 48.3 µM -0.605059227688265 0.291106321770027 no 2394 0.272569821944624 791 1104023 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.605668641512666 0.290900484397709 no 2395 0.272367405686296 796 521171 SGTC_2853 9015042 58.44 µM -0.605789768184008 0.29085958040877 no 2396 0.272327182467929 787 6457456 SGTC_214 4373-3496 70 µM -0.606059874847762 0.290768376160042 no 2397 0.27223749725079 814 3779166 SGTC_636 0kpi-0074 126 µM -0.606384079399502 0.290658922873174 no 2398 0.272129868956594 808 616434 SGTC_3187 9109394 49.47 µM -0.608572993087397 0.289920438068276 no 2399 0.271403755033301 787 17098090 SGTC_3134 9127454 49.47 µM -0.60970638872593 0.289538404759189 no 2400 0.271028160855101 808 24262820 SGTC_802 4112-3352 742 µM -0.609935407779233 0.289461238097611 no 2401 0.270952298096214 767 704594 SGTC_287 k060-0039 29.6 µM -0.610448392592857 0.289288425856186 no 2402 0.270782409887651 797 5861974 SGTC_1527 coumarin 137 µM -0.610967139228843 0.289113721919209 no 2403 0.270610667594301 841 323 A hepatotoxic, DNA x-linker. SGTC_1221 2958-7315 257 µM -0.611427354599558 0.288958771737638 no 2404 0.270458348899674 795 4562705 SGTC_2379 9035213 200 µM -0.611602658764327 0.288899758754539 no 2405 0.270400339288084 792 646551 SGTC_1024 4507-0395 26 µM -0.611727036842957 0.288857892559077 no 2406 0.270359185315097 771 4201836 SGTC_24 0417-1663 219 µM -0.612441673611612 0.288617398110386 no 2407 0.270122788403231 826 4329390 SGTC_155 k072-0202 43.6 µM -0.614437543609965 0.28794623433446 no 2408 0.269463116490017 825 5857737 SGTC_1948 st076329 66.6 µM -0.61494377714376 0.287776117225349 no 2409 0.269295925427023 804 24208413 SGTC_2121 5257820 149.641 µM -0.614992050010365 0.28775989786305 no 2410 0.269279985320849 785 791256 SGTC_3113 9123498 49.47 µM -0.615203371609573 0.287688900294383 no 2411 0.269210210723501 820 8897275 SGTC_2333 9017922 200 µM -0.617936158451648 0.286771514352072 no 2412 0.268308711370356 812 3163164 SGTC_105 0111-0055 734.78 µM -0.619073339599798 0.286390176059663 no 2413 0.267934022810651 798 5179370 SGTC_3042 9091578 49.47 µM -0.619156606826864 0.286362262982699 no 2414 0.26790659754121 790 25236497 SGTC_2057 5236571 38.335 µM -0.621473420549482 0.285586132418266 no 2415 0.267144088705398 802 54684039 YBR257W POP4 SGTC_1001 4048-4355 44.4 µM -0.621556335061319 0.285558374695078 no 2416 0.267116820232551 805 21824233 SGTC_505 gw-5074 63.9 µM -0.622176817703046 0.285350693259846 no 2417 0.266912803896943 804 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2804 7954240 19.48 µM -0.623429425112053 0.284931653010288 no 2418 0.266501183257247 801 828705 SGTC_2018 5133068 143 µM -0.623952506204751 0.284756751316498 no 2419 0.266329388111394 825 785362 SGTC_763 3453-1109 128 µM -0.623975071568081 0.284749207329142 no 2420 0.266321978246572 807 1560353 SGTC_2190 6049624 200 µM -0.62565900043648 0.284186510404663 no 2421 0.265769315372431 810 2265554 SGTC_82 0054-0107 293.755 µM -0.626598091760331 0.283872937402197 no 2422 0.265461359747618 802 3104697 SGTC_2744 captopril 92.04 µM -0.626754816853097 0.28382062128705 no 2423 0.265409982622024 772 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2931 9014674 55.67 µM -0.628070625501535 0.283381575773633 no 2424 0.26497883749326 819 2996810 SGTC_686 1319-0111 510 µM -0.628779298824871 0.283145247929506 no 2425 0.264746777216621 859 4562600 SGTC_1406 3909-7906 11.9 µM -0.629187551289131 0.28300914715047 no 2426 0.264613138881953 811 X1406 SGTC_1191 1487-1166 10.6 µM -0.629693756506827 0.28284043508752 no 2427 0.264447484124607 829 3955771 SGTC_1755 st041960 45.185 µM -0.634683304796808 0.28118006906237 no 2428 0.262817492204971 828 2257073 SGTC_2348 9022543 33.42 µM -0.635239625732063 0.280995234883987 no 2429 0.262636071480718 817 3162678 YDL140C RPO21 SGTC_1488 4013-0813 75.9 µM -0.637814178940504 0.280140620970241 no 2430 0.261797324288607 803 2910057 SGTC_1260 0700-1617 7.75 µM -0.638163256415873 0.280024842963007 no 2431 0.261683706446828 795 2853078 SGTC_488 nitrendipine 139 µM -0.638766898729759 0.279824688567542 no 2432 0.261487292489911 808 4507 Dihydropyridine L-type calcium channel blocker. SGTC_3081 9117243 49.47 µM -0.639634434776332 0.279537154460448 no 2433 0.261205145051582 817 45595589 SGTC_1315 1237-0019 3.69 µM -0.6402788220871 0.279323673137144 no 2434 0.260995673241337 801 825140 SGTC_1884 5633444 25 µM -0.640653338806433 0.279199634593716 no 2435 0.260873968311215 811 5724239 SGTC_954 1189-0853 2.85 µM -0.641315633175156 0.278980350721548 no 2436 0.260658817114128 826 2828194 SGTC_1504 k297-0033 30 µM -0.642437043542327 0.278609245904946 no 2437 0.260294727056681 774 4388117 SGTC_2846 9008642 19.48 µM -0.642687597339503 0.278526363791418 no 2438 0.260213415191093 852 2992898 SGTC_2187 6125751 200 µM -0.644114157052293 0.278054693004556 no 2439 0.259750705378867 811 874498 SGTC_2196 6573537 42.6665 µM -0.646328287338208 0.277323396366583 no 2440 0.259033386062019 832 2903087 SGTC_882 0843-0131 351 µM -0.646674677840844 0.277209073508954 no 2441 0.258921257494258 809 5425421 SGTC_3257 9139206 32.98 µM -0.64719684846228 0.277036779696239 no 2442 0.258752275373528 815 4910041 SGTC_2549 cedrol 20.94 µM -0.648756847102198 0.276522359761726 no 2443 0.258247776988459 812 6708665 A sedative which affects the nervous system. SGTC_2484 5809818 12.04 µM -0.651750983643208 0.275536337225829 no 2444 0.257280913473449 811 2870548 SGTC_853 0419-0306 21 µM -0.652036966115737 0.27544224864598 no 2445 0.257188662843495 822 762713 SGTC_2612 dictamnine 15.46 µM -0.652151733415076 0.275404494510341 no 2446 0.257151646684743 806 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.652482706542484 0.27529563102999 no 2447 0.257044912683199 808 688664 SGTC_3201 9113999 49.47 µM -0.6540603337803 0.274777010114481 no 2448 0.256536467800909 816 16649224 SGTC_1925 st057770 10.1 µM -0.654689310490117 0.27457037798601 no 2449 0.256333904490406 809 5989122 SGTC_2224 6650123 117.647 µM -0.65881427555655 0.273217142783556 no 2450 0.25500751954442 820 2908370 SGTC_867 0518-0118 155 µM -0.660259967118834 0.272743652689441 no 2451 0.254543507789281 822 6848158 SGTC_3222 9128301 49.47 µM -0.660890570914012 0.272537246161893 no 2452 0.254341246700833 805 4911358 SGTC_2416 tofa 880 nM -0.661525678170988 0.272329443996368 no 2453 0.254137626345123 811 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2152 5568786 200 µM -0.662228761280544 0.272099492501197 no 2454 0.253912312153731 827 5399883 SGTC_1740 st038286 13.222 µM -0.663907205713887 0.271550928354395 no 2455 0.253374852047342 809 716786 SGTC_723 4182-0001 115 µM -0.664839211550561 0.271246559919421 no 2456 0.253076669866865 827 744821 YLR208W SEC13 SGTC_1749 st037932 54.2 µM -0.666169920263245 0.270812280630215 no 2457 0.252651248466462 842 594497 SGTC_2585 alliin 100 µM -0.669189245449851 0.26982820706722 no 2458 0.251687382851952 837 87310 A garlic compound which reacts with lipids. SGTC_1118 chelidonine 707.474 nM -0.669680155868244 0.269668376466811 no 2459 0.251530852220976 823 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_3142 9086498 49.47 µM -0.670075891973158 0.269539567250345 no 2460 0.251404706119957 816 25236367 SGTC_2767 sibutramine 71.45 µM -0.671779082198588 0.268985543395602 no 2461 0.250862173654117 824 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1633 st005664 67.9 µM -0.672098055124441 0.268881849572107 no 2462 0.250760637293025 832 2063822 SGTC_1254 0550-0035 264 µM -0.673431283221641 0.268448652384174 no 2463 0.250336476039678 819 15121435 SGTC_2808 7946468 45.46 µM -0.673463521591117 0.268438181726127 no 2464 0.250326224241659 837 2970879 SGTC_1029 k015-0030 64.7 µM -0.674141978306141 0.268217874299377 no 2465 0.250110526719574 825 2208316 SGTC_134 0269-0018 6.916 µM -0.674668424329704 0.268046990257477 no 2466 0.249943224967651 829 4378915 SGTC_481 bay k-8644 50 µM -0.674771037912752 0.268013688338038 no 2467 0.249910621833572 838 2303 A calcium channel antagonist. SGTC_3109 9122853 49.47 µM -0.675321090013162 0.267835211516986 no 2468 0.249735893765707 861 1234709 SGTC_1471 k673-0312 37 µM -0.675358194241151 0.267823174368517 no 2469 0.249724109672654 816 24099884 SGTC_1387 3342-1166 1.8 µM -0.675777025238338 0.267687318435704 no 2470 0.249591111796981 819 3418228 SGTC_860 0443-0016 25.1 µM -0.675950720939323 0.267630987066538 no 2471 0.249535966558634 836 5337942 SGTC_1919 st067113 52.3 µM -0.675978754513896 0.267621896039226 no 2472 0.24952706701332 838 1268243 SGTC_2242 6630449 61.2675 µM -0.677085433348881 0.267263134806278 no 2473 0.249175875263279 818 691249 YDR170C SEC7 SGTC_1031 k035-0009 16 µM -0.67770825209778 0.267061337279614 no 2474 0.248978346588907 831 5180959 SGTC_385 1494-0393 12.4 µM -0.67851014379789 0.266801632239908 no 2475 0.248724147195714 822 3090647 SGTC_2753 fluvastatin 17.09 µM -0.679320290430905 0.266539383375286 no 2476 0.248467471404499 848 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1295 1013-0063 9.78 µM -0.679515608606315 0.266476177330432 no 2477 0.248405610586629 827 6826038 SGTC_2389 9091542 195.52 µM -0.679689582174093 0.266419884903801 no 2478 0.248350516907091 826 3626624 YOL127W RPL25 SGTC_2215 7188065 200 µM -0.680232222329398 0.266244342110968 no 2479 0.248178716316237 828 940217 SGTC_2050 5263056 171 µM -0.680755152939717 0.26607523072311 no 2480 0.248013215784085 820 763468 YGL055W OLE1 SGTC_2495 cafestol 54.53 µM -0.680923543853131 0.266020786090938 no 2481 0.247959934853128 838 16667697 An anti-infammatory. SGTC_132 0417-1715 25.805 µM -0.681470794910631 0.265843886290666 no 2482 0.247786820160654 839 6769098 SGTC_2464 5717415 7.67 µM -0.68210864934282 0.2656377740685 no 2483 0.247585125910079 819 5285744 SGTC_2130 NSC 7 2.4545 µM -0.683319671930874 0.265246675046431 no 2484 0.247202433133492 814 21448 SGTC_2431 5490079 200 µM -0.684848276735202 0.264753430783874 no 2485 0.246719833845038 862 5722345 SGTC_1007 4101-0031 70 µM -0.685451425394494 0.264558937511429 no 2486 0.246529551309131 847 1146276 SGTC_2349 9023730 187.07 µM -0.686036991637956 0.264370183490296 no 2487 0.24634489095463 834 4126287 SGTC_2281 7943571 200 µM -0.688527035269032 0.263568298078288 no 2488 0.245560475686154 831 1244024 SGTC_2551 apiole 73.87 µM -0.689725211519542 0.263182884134054 no 2489 0.245183504062085 818 10659 A possible DNA adduct former. SGTC_2545 solidagenone 89.61 µM -0.690276319054254 0.263005707660906 no 2490 0.245010218499398 784 6708572 An anti ulcer agent SGTC_391 gliotoxin 8.33 µM -0.690749781972957 0.262853541985311 no 2491 0.24486139948163 848 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_215 1287-0124 461.5 µM -0.691340546947559 0.262663739894736 no 2492 0.244675778286127 834 5560863 SGTC_2658 polymyxin b sulfate 77.05 µM -0.691633073963733 0.262569782225346 no 2493 0.24458389294701 831 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.693442053602424 0.26198913271371 no 2494 0.244016089402253 829 115019 SGTC_1239 0337-0584 35.4 µM -0.69531194996544 0.261389622727204 no 2495 0.243429913470992 849 914301 YML130C ERO1 SGTC_2471 5466956 24.79 µM -0.69789201597062 0.260563582589516 no 2496 0.242622363914342 833 724419 SGTC_3246 9135460 32.98 µM -0.699011503454249 0.260205583319302 no 2497 0.242272420920885 837 41446951 SGTC_2570 licareol 100 µM -0.699648503533623 0.260001991210456 no 2498 0.242073421878726 834 443158 SGTC_1241 0364-0022 50.8 µM -0.69996038447414 0.25990234065567 no 2499 0.24197602249836 845 4563895 SGTC_69 0096-0274 206.684 µM -0.700382953597194 0.259767355032772 no 2500 0.241844089485134 861 6741392 SGTC_648 0375-0473 33.3 µM -0.702309153558558 0.259152507700195 no 2501 0.24124319301689 835 1713139 SGTC_85 0868-0259 160.055 µM -0.702720567652159 0.25902128097522 no 2502 0.241114953706239 820 83173 SGTC_1739 st037196 92.5 µM -0.703799179903597 0.258677404564899 no 2503 0.240778922255575 841 612214 SGTC_221 trifluoperazine 10.304 µM -0.705694177141082 0.258073826254497 no 2504 0.240189171434362 853 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2705 st078069 42.8 µM -0.705725017641669 0.258064009245382 no 2505 0.240179579934942 830 1530061 SGTC_71 0417-1750 47.813 µM -0.706461149630375 0.25782974452147 no 2506 0.239950702379256 817 6811472 SGTC_809 3998-0021 90 µM -0.706954560960909 0.257672784386346 no 2507 0.239797357939195 839 715485 SGTC_409 arachidonic acid 100 µM -0.707749865789746 0.257419892731172 no 2508 0.239550302354538 839 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2789 5281112 71.43 µM -0.708290238551991 0.257248138181472 no 2509 0.239382518853262 834 765948 SGTC_470 aa-861 153 µM -0.708897734073281 0.257055120181257 no 2510 0.239193970678504 835 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_815 1582-0027 36.9 µM -0.710346378866725 0.256595150134008 no 2511 0.238744682967156 861 3128206 SGTC_2092 5303694 80.6725 µM -0.711355326503028 0.256275045048184 no 2512 0.238432037423388 833 1963699 SGTC_837 0091-0265 12.5 µM -0.712017113120994 0.256065195561865 no 2513 0.238227089483591 852 759367 SGTC_3175 9106517 49.47 µM -0.712751230512002 0.25583251522276 no 2514 0.237999854466228 851 41468073 SGTC_2997 9067075 71.4286 µM -0.712770695025562 0.255826347398758 no 2515 0.237993831135629 839 27209819 SGTC_1796 st049173 110.4 µM -0.713965891159615 0.255447767994476 no 2516 0.237624135575463 855 94134 SGTC_361 000s-0510 1.45 µM -0.716063433157594 0.254784078122647 no 2517 0.236976090759329 848 660 SGTC_2201 6605497 169.863 µM -0.716571465214386 0.254623466008016 no 2518 0.236819278283959 838 670741 SGTC_270 tamoxifen 5.46 µM -0.716693161992795 0.254584999977785 no 2519 0.236781723038612 863 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_3333 9141820 12.094 µM -0.720509904422509 0.253380146983417 no 2520 0.235605551878494 840 1939433 SGTC_1625 st003711 30.1 µM -0.721871120096021 0.252951170413091 no 2521 0.23518685927423 855 24207034 YER133W GLC7 SGTC_228 caffeine 993.056 µM -0.722236494325431 0.252836090653389 no 2522 0.235074544801587 814 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2639 lactacystin 53 µM -0.72253202467465 0.252743029373356 no 2523 0.234983721716706 838 3870 A proteasome inhibitor. SGTC_2356 9061756 188.97 µM -0.724351806271082 0.252170385412816 no 2524 0.234424889617181 830 20104043 SGTC_920 mycophenolic acid 780.421 nM -0.724392541579086 0.252157574770937 no 2525 0.234412388735473 838 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3008 9078912 71.4286 µM -0.72592243986611 0.251676693400576 no 2526 0.233943159576739 847 16648731 SGTC_2038 4100038 30.985 µM -0.726809650390327 0.25139804526486 no 2527 0.23367128524774 837 3596803 SGTC_2005 4024620 188 µM -0.727796689755455 0.251088235394444 no 2528 0.233369025596794 854 236743 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.729608285095369 0.250520141569543 no 2529 0.232814828228149 847 5357218 A potent inhibitor of glutathione S-transferases. SGTC_459 nigericin 15.3 µM -0.730074165819157 0.250374157322951 no 2530 0.232672425807296 861 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_892 0929-0076 29 µM -0.731011164180808 0.250080684440562 no 2531 0.232386166894503 847 5751038 SGTC_2999 9069765 71.4286 µM -0.731086532451539 0.250057086628678 no 2532 0.232363149927696 820 2097066 SGTC_901 1112-0062 60.1 µM -0.731453266867337 0.249942278914312 no 2533 0.232251169785414 844 1908457 SGTC_3089 9117425 49.47 µM -0.732390712470651 0.249648934916552 no 2534 0.231965062952324 857 9401657 SGTC_1651 st011928 86.1 µM -0.733414100768039 0.249328906767883 no 2535 0.231652950752166 860 720198 SGTC_1121 fusaric acid 630.51 nM -0.735154437723834 0.24878517972624 no 2536 0.231122721883596 843 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2514 salinomycin 42.74 µM -0.736680192036948 0.248309013804089 no 2537 0.230658427650893 859 23682228 A polyether potassium ionophore. SGTC_1563 conessine 56.1 µM -0.737906983477899 0.247926502567574 no 2538 0.230285487491427 850 441082 An anti-amoebic, histamine inhibitor. SGTC_2076 5212012 200 µM -0.738901568925297 0.247616623693768 no 2539 0.229983384791648 841 604802 SGTC_1840 st055363 71 µM -0.740122700800244 0.247236443802952 no 2540 0.22961277274697 863 676033 SGTC_413 propylparaben 100 µM -0.74105677141194 0.246945846665872 no 2541 0.229329509431465 847 7175 A pharmaceutical preservative. SGTC_3044 9093193 49.47 µM -0.741590179647959 0.246779980956123 no 2542 0.229167837645747 847 25236277 SGTC_1564 D-Arginine 115 µM -0.742028089770286 0.246643855413886 no 2543 0.229035158369899 855 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2443 5493264 126.67 µM -0.743225262520323 0.24627191638241 no 2544 0.228672655546026 865 5340055 SGTC_2227 7312221 64.1025 µM -0.744207830078715 0.245966875968111 no 2545 0.228375375859456 873 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2322 7413319 38.22 µM -0.744346969468572 0.245923696209715 no 2546 0.228333296250399 839 1840400 SGTC_196 k015-0023 18.111 µM -0.745705005327492 0.245502464469175 no 2547 0.227922817449624 839 5211998 SGTC_1461 k072-0203 53.8 µM -0.747233481160288 0.245028830187714 no 2548 0.227461318587524 850 5418714 SGTC_3256 9138902 49.47 µM -0.747544696195986 0.244932453137706 no 2549 0.22736741671324 876 17228773 SGTC_2825 7998094 58.44 µM -0.747836723804962 0.244842036602199 no 2550 0.227279324062018 848 2987815 SGTC_1330 1469-0054 61.8 µM -0.748602516492023 0.24460501997701 no 2551 0.227048407452951 849 7102664 SGTC_1277 0873-0036 22 µM -0.750345019630477 0.244066167435546 no 2552 0.226523467494816 858 5965735 SGTC_376 3970-0862 59.1 µM -0.750881281249719 0.243900462557132 no 2553 0.226362053324482 870 3135186 SGTC_2385 9074692 200 µM -0.751538929666964 0.243697332051731 no 2554 0.22616419057302 848 17046906 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.75371902651921 0.243024610534792 no 2555 0.225508977310656 878 4620898 SGTC_676 falcarinol 140 µM -0.754799451277284 0.242691592002347 no 2556 0.225184661591424 869 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2778 tioconazole 65.09 nM -0.758608433314536 0.24151952550272 no 2557 0.224043413190347 861 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_175 3793-3120 23.7 µM -0.75870620655761 0.241489480099309 no 2558 0.224014161658197 879 5322297 SGTC_1875 nocodazole 6 µM -0.759483514678839 0.241250688048948 no 2559 0.223781685941188 846 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2430 5571206 200 µM -0.759630583039622 0.241205522522663 no 2560 0.223737716471199 856 1731771 SGTC_1138 3761-0006 1.03 µM -0.759919581988385 0.241116782699839 no 2561 0.223651327896661 849 12061087 SGTC_602 3130-1533 38.1 µM -0.761252907744524 0.240707602525933 no 2562 0.223253011209148 860 720941 SGTC_341 1486-1430 230 µM -0.763849868177292 0.239911715515263 no 2563 0.222478357567581 870 2054753 YPL210C SRP72 SGTC_2788 5282734 71.43 µM -0.764256969052967 0.239787082112725 no 2564 0.222357061589673 862 743706 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.765108468576022 0.239526510896435 no 2565 0.222103478747303 842 6312947 SGTC_641 4092-0595 30 µM -0.765364675209636 0.239448138213434 no 2566 0.222027210839707 866 786260 SGTC_276 colchicine 750 µM -0.767743110956185 0.238721252139213 no 2567 0.221319909190789 862 2833 A microtubule depolymerizer. SGTC_104 0074-0074 590.992 µM -0.770417138667465 0.237905472435891 no 2568 0.22052624507265 849 3943124 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.770423326084228 0.237903586582323 no 2569 0.220524410511175 852 6708514 SGTC_2032 5185112 25.99 µM -0.771404703006813 0.237604577941576 no 2570 0.22023354417081 825 5718189 SGTC_2607 solasodine 47.35 µM -0.771410111985506 0.237602930490599 no 2571 0.220231941635304 875 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_3241 9133421 49.47 µM -0.771998289950271 0.237423822364421 no 2572 0.220057720159838 897 17018221 SGTC_1991 st073000 8.92 µM -0.772564563677318 0.23725145443188 no 2573 0.219890061564976 875 4301969 YIL048W NEO1 SGTC_283 0987-0079 11.7 µM -0.774156176753273 0.23676735197325 no 2574 0.219419220032935 851 411556 SGTC_2063 5246145 200 µM -0.778572792588536 0.235426850906419 no 2575 0.218115705645219 872 711240 SGTC_272 doxorubicin 8.13 µM -0.779185355123977 0.235241261424344 no 2576 0.217935267832473 871 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2815 7968870 71.43 µM -0.780035732085244 0.234983754722499 no 2577 0.21768492159987 888 2977326 YHR190W ERG9 SGTC_2806 7952793 58.44 µM -0.780360370794685 0.23488549041988 no 2578 0.217589393555179 873 2972490 SGTC_2919 7978188 46.38 µM -0.781509918244542 0.234537718635396 no 2579 0.217251322796971 840 2980291 SGTC_984 1492-0255 2.91 µM -0.782493424798677 0.234240405316563 no 2580 0.216962324022966 861 1585198 SGTC_2361 9034121 116 µM -0.783385409141686 0.233970939616109 no 2581 0.216700410870836 900 6496917 SGTC_1437 4092-1038 11.6 µM -0.786116438761981 0.233146972803364 no 2582 0.215899637232377 862 3977136 SGTC_1814 st052110 31.539 µM -0.786730246705311 0.232962005499287 no 2583 0.215719896990641 867 674163 SGTC_2583 asiatic acid 100 µM -0.787255569192638 0.232803767499558 no 2584 0.215566136693239 889 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_3065 9113888 49.47 µM -0.787417601545881 0.232754972057052 no 2585 0.21551872314367 860 16648368 SGTC_3267 9137951 49.47 µM -0.787768365302434 0.23264936032375 no 2586 0.215416104148913 906 16643986 SGTC_3001 9076041 71.4286 µM -0.788096578280074 0.232550562550611 no 2587 0.215320108257307 856 16004211 SGTC_222 nsc-310342 10.666 µM -0.788963557403164 0.232289699095063 no 2588 0.215066653200145 872 432556 SGTC_1676 st018489 23.4 µM -0.789266802795324 0.232198494697909 no 2589 0.214978042516391 864 3696235 SGTC_1699 st031318 29.054 µM -0.789270985036343 0.232197236982117 no 2590 0.214976820580979 859 5340658 SGTC_1736 st036774 51 µM -0.78954005951185 0.232116326798406 no 2591 0.2148982129227 884 1272247 SGTC_3277 9138724 49.47 µM -0.792958042144035 0.231089912819298 no 2592 0.213901134388927 843 15943418 SGTC_2898 9056270 58.44 µM -0.793189380013146 0.231020534120268 no 2593 0.213833747006967 811 19154699 SGTC_572 0960-0087 17.7 µM -0.793506423868524 0.230925470909565 no 2594 0.213741414051247 881 6796365 SGTC_2722 naftopidil 47.16 µM -0.794924474383055 0.230500546564016 no 2595 0.21332871828572 881 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2857 9024691 58.44 µM -0.795024030670241 0.230470730562889 no 2596 0.213299761846058 886 16478292 SGTC_2357 9067248 200 µM -0.79509270531133 0.230450164527957 no 2597 0.213279788821956 891 9150235 SGTC_473 2-arachidonoylglycerol 10 µM -0.796198746499605 0.230119079074309 no 2598 0.212958263015407 854 5282280 An endocannabinoid. SGTC_1086 cerivastatin 2.18 µM -0.796620811818741 0.229992807052068 no 2599 0.212835643366061 833 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_605 1315-0399 119 µM -0.797559630598892 0.229712073647065 no 2600 0.21256304282305 879 24020461 SGTC_877 0771-0151 33.1 µM -0.798494331646836 0.229432762314703 no 2601 0.212291840623731 879 6166523 SGTC_3289 9119912 71.43 µM -0.798827010714332 0.229333395692541 no 2602 0.21219536307793 874 17014829 SGTC_1691 st019933 84.6 µM -0.799707891087165 0.229070405492342 no 2603 0.211940029954974 894 6176082 SGTC_321 4534-3890 65.3 µM -0.79981981155071 0.229037003327785 no 2604 0.211907601417227 871 699746 SGTC_807 1315-0151 48 µM -0.799954961495911 0.228996672070003 no 2605 0.211868446092631 891 4011080 SGTC_844 0330-0132 15.3 µM -0.800288220641463 0.228897238370589 no 2606 0.211771913124652 864 2828079 SGTC_3174 9107204 49.47 µM -0.801365204098741 0.228576067241918 no 2607 0.211460126501131 896 3938802 SGTC_1477 0139-0234 16 µM -0.801577236487772 0.228512866131358 no 2608 0.211398774827606 870 620880 SGTC_1356 1502-0781 85.8 µM -0.80297602687404 0.228096170701047 no 2609 0.210994295482185 873 567702 SGTC_1362 1611-0397 101 µM -0.80484473731306 0.227540154837761 no 2610 0.210454640868159 877 27816 SGTC_3149 9097855 49.47 µM -0.805778594800349 0.227262581271866 no 2611 0.210185261181854 842 25236625 YMR079W SEC14 SGTC_1292 0kpi-0043 232 µM -0.806006616713799 0.227194834556066 no 2612 0.210119516962016 862 3333905 SGTC_209 4077-0173 175.592 µM -0.806557939067831 0.22703108032763 no 2613 0.20996060734738 860 15993494 SGTC_1423 4048-0112 5.59 µM -0.807601636350143 0.226721262804021 no 2614 0.209659972220605 858 X1423 SGTC_2785 7756463 72.73 µM -0.80761833225745 0.226716308627722 no 2615 0.209655165052585 886 2201551 SGTC_2163 5671233 125 µM -0.809327317994147 0.22620952458177 no 2616 0.209163448416701 861 701023 SGTC_664 1222-0054 14.9 µM -0.809970964656633 0.226018823123699 no 2617 0.208978431824316 866 6813991 SGTC_644 1498-1197 63.3 µM -0.811829153132506 0.225468783984587 no 2618 0.208444835653102 889 6741615 SGTC_83 0170-0301 39.027 µM -0.813037172518127 0.225111607067176 no 2619 0.208098372992865 872 3089716 SGTC_1367 1812-0510 76.9 µM -0.814325709701252 0.224730976919859 no 2620 0.207729192528808 862 1142582 YDR527W RBA50 SGTC_2493 resveratrol 26.09 µM -0.814560324603123 0.224661711657111 no 2621 0.207662014368017 845 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_855 0428-0020 25 µM -0.815293081618666 0.224445458085381 no 2622 0.207452283978301 868 6812414 SGTC_2413 inermin 26.06 µM -0.817228241709157 0.223874915820128 no 2623 0.206899002974383 888 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1844 rapamycin 4 nM -0.817720151831142 0.223730017706611 no 2624 0.206758500450362 859 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2473 5854593 8.94 µM -0.817794415529118 0.223708147063638 no 2625 0.206737293685577 884 2872951 SGTC_3099 9120367 49.47 µM -0.81801434005943 0.223643386467427 no 2626 0.206674499522534 882 24824940 SGTC_1682 st012968 530 nM -0.818944035747745 0.223369739246702 no 2627 0.206409172084059 870 24207270 SGTC_2417 cerulenin 830 nM -0.819806509521194 0.223116048615341 no 2628 0.206163209782436 875 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_3017 9080681 49.47 µM -0.820186686001457 0.223004274477478 no 2629 0.206054845360814 884 16451914 SGTC_1032 k061-1018 98.7 µM -0.821160257897112 0.222718184023039 no 2630 0.205777495247529 897 4005393 SGTC_3120 9124077 49.47 µM -0.821972443586681 0.222479678083605 no 2631 0.205546290234485 903 18774327 YGL155W CDC43 SGTC_1579 chlormadinone acetate 49.4 µM -0.822523048030204 0.222318070805346 no 2632 0.20538963734731 889 45114258 A steroidal progestin. SGTC_1047 2043-3044 82 µM -0.822730436900273 0.22225721770361 no 2633 0.205330651371485 910 669592 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.823719391356518 0.221967164388416 no 2634 0.205049509308362 875 1377 SGTC_2138 5575593 77.673 µM -0.82494703410809 0.221607406354217 no 2635 0.204700830920938 875 762213 SGTC_50 0929-0078 56.389 µM -0.825294026098534 0.221505781544575 no 2636 0.204602341295416 850 1377751 SGTC_3066 9117245 49.47 µM -0.825550986913703 0.221430541665373 no 2637 0.204529424142004 859 17176980 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.825804620743567 0.221356290281779 no 2638 0.204457466246719 875 5379071 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.82797663693188 0.220721015179155 no 2639 0.203841865581351 885 4213774 SGTC_3304 9125678 46.087 µM -0.828086229391676 0.220688989081242 no 2640 0.203810833795967 885 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_753 1322-0200 289 µM -0.829267003387246 0.22034410151427 no 2641 0.203476668953281 879 5403907 SGTC_1921 5740136 50 µM -0.831465589256201 0.219702749303965 no 2642 0.202855329872289 868 1774243 SGTC_354 2783-3500 4.88 µM -0.833032905534701 0.21924620065739 no 2643 0.202413085729258 878 6740761 SGTC_553 k007-0256 45.7 µM -0.835818799054963 0.218436036283365 no 2644 0.201628424514464 881 6287000 SGTC_2905 7799065 20.05 µM -0.835964744315517 0.218393641593475 no 2645 0.201587368572977 863 1296806 SGTC_781 4335-2806 94.4 µM -0.836825279115356 0.218143766808905 no 2646 0.201345392897641 929 845254 SGTC_1344 1488-0097 29.1 µM -0.837292067251544 0.218008293794742 no 2647 0.201214208580182 885 747966 SGTC_368 fentichlor 4.58 µM -0.837536840441311 0.21793727418639 no 2648 0.201145438964972 909 7329 A pesticide. SGTC_1905 st060207 84.5 µM -0.837981267665953 0.21780836015347 no 2649 0.201020612103931 861 1948547 SGTC_2507 purpurin 79.67 µM -0.839696157800156 0.217311338217633 no 2650 0.200539384410434 892 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_3345 9148410 3.559 µM -0.840669445903454 0.217029544378588 no 2651 0.20026657101692 861 4903596 SGTC_1774 st048371 48.465 µM -0.841184846729337 0.216880407136095 no 2652 0.200122194132785 896 4242727 SGTC_156 3474-0145 5.642 µM -0.841227418546875 0.216868091133452 no 2653 0.200110271481476 855 2265471 SGTC_2645 abamectin 100 µM -0.844242118730109 0.215996968699918 no 2654 0.199267061450175 849 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1815 st051655 58.2 µM -0.845081701536195 0.215754725709838 no 2655 0.19903261207131 885 5984156 SGTC_364 0083-0097 67.7 µM -0.845254709675165 0.215704827626256 no 2656 0.198984321059231 908 5207356 SGTC_2636 apigenin dimethyl ether 100 µM -0.845403752981139 0.215661846716547 no 2657 0.198942724909032 890 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1654 st012436 41.8 µM -0.84749462951132 0.215059406176042 no 2658 0.19835973962284 875 4323132 SGTC_2243 6634756 200 µM -0.848005551079809 0.214912343945354 no 2659 0.19821743963096 874 885676 SGTC_783 0848-0141 92.7 µM -0.848501542643998 0.214769635016135 no 2660 0.19807935685337 885 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2968 9090663 33.37 µM -0.849165141817795 0.214578787408606 no 2661 0.197894703416593 894 25236811 SGTC_1927 st060202 13.8 µM -0.849973987262604 0.214346301103071 no 2662 0.197669774350479 865 688887 SGTC_3168 9103419 49.47 µM -0.850486567368667 0.214199046160602 no 2663 0.197527312719831 873 16649256 SGTC_2624 nerol 100 µM -0.85252334114451 0.213614500004139 no 2664 0.196961844877375 901 637566 A natural product oil. SGTC_2124 5246320 200 µM -0.854640098239879 0.213007984954114 no 2665 0.19637521090755 890 579342 SGTC_1672 st016598 6.51 µM -0.855120042387403 0.212870606278248 no 2666 0.19624234754715 900 4665860 YNL267W PIK1 SGTC_1715 st032160 10.2275 µM -0.858643407770259 0.211863666552832 no 2667 0.195268640904078 869 5289825 SGTC_2300 7976697 71.57 µM -0.859254106010663 0.211689419392804 no 2668 0.195100169177961 876 2236109 SGTC_3261 9137475 49.47 µM -0.859271295289608 0.211684516084628 no 2669 0.195095428495309 831 17027690 SGTC_504 lovastatin 124 µM -0.860482524300917 0.211339175733343 no 2670 0.194761556345132 896 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_743 1275-0778 158 µM -0.860496835913612 0.211335097242222 no 2671 0.194757613464795 891 2849257 YMR203W TOM40 SGTC_1073 triclabendazole 3.09 µM -0.861081230037845 0.211168597304053 no 2672 0.194596653091042 882 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1232 0279-0259 161 µM -0.863425037595253 0.210501595091419 no 2673 0.19395190916638 880 1560000 SGTC_57 miconazole 162.5 nM -0.863523606793564 0.210473571328761 no 2674 0.193924822913197 863 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2149 5554786 194.827 µM -0.863523669876775 0.21047355339456 no 2675 0.193924805579028 902 745063 YPR165W RHO1 SGTC_786 4544-0069 423 µM -0.864740937907196 0.210127657986316 no 2676 0.193590497339838 886 748821 YLR208W SEC13 SGTC_1207 2099-0101 141 µM -0.865464072002628 0.209922332471169 no 2677 0.193392063654562 890 5837381 SGTC_2079 5212404 121 µM -0.865776596225222 0.209833631358061 no 2678 0.193306342969466 874 758462 SGTC_1846 st056244 14.8 µM -0.866881266151409 0.209520278834944 no 2679 0.193003534526062 906 5393182 SGTC_1587 estradiol valerate 56.1 µM -0.868024075851944 0.209196397392379 no 2680 0.192690576354689 902 13791 A steroid. SGTC_2278 7948257 134.34 µM -0.872719818504473 0.207868683429689 no 2681 0.191407906332186 886 1247028 SGTC_2425 5628681 7.85 µM -0.873220128522402 0.207727515483074 no 2682 0.1912715527857 899 5714958 SGTC_640 3381-0960 37.1 µM -0.874766667283411 0.207291500898025 no 2683 0.190850438664373 903 1745025 SGTC_1274 0865-0114 173 µM -0.87613207314807 0.206907003162227 no 2684 0.190479119249431 871 870624 SGTC_1861 st057647 17.4 µM -0.879022067246029 0.206094575526004 no 2685 0.189694655495288 876 688668 SGTC_3079 9117512 49.47 µM -0.879671249380715 0.205912339642525 no 2686 0.18951871435545 950 7185044 SGTC_3196 9111891 49.47 µM -0.880067264691993 0.205801218721253 no 2687 0.189411435734316 912 18891510 SGTC_565 1418-0001 44.5 µM -0.881052031351903 0.205525049918263 no 2688 0.189144829303118 909 2862145 SGTC_3200 9114385 49.47 µM -0.881298730685903 0.205455899827512 no 2689 0.1890780764684 883 17018030 YLR208W SEC13 SGTC_2141 5621638 7.665 µM -0.881555553341532 0.205383926838753 no 2690 0.189008599844195 897 2856238 SGTC_219 mitoxanthrone 164.414 µM -0.881718176864154 0.205338360328772 no 2691 0.188964614453997 915 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_394 menadione 8.33 µM -0.883689579009773 0.204786458505946 no 2692 0.188431903657842 901 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2938 9059746 27.26 µM -0.885624000667663 0.204245768007506 no 2693 0.187910087002621 919 6471769 SGTC_2918 7977171 22.06 µM -0.887074533525636 0.2038408876163 no 2694 0.187519386928207 877 2236483 SGTC_2685 mycophenolic acid 18.85 µM -0.887464934755648 0.203731998519808 no 2695 0.187414318411222 876 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_181 1447-1644 8.07 µM -0.891223176219077 0.202685540217618 no 2696 0.18640472663081 931 534600 SGTC_1181 1222-0449 220 µM -0.891544262023631 0.202596285112747 no 2697 0.186318628526845 921 658318 SGTC_2377 9073351 62.6 µM -0.891546473182424 0.202595670538539 no 2698 0.186318035697311 926 7337946 YHR072W ERG7 SGTC_1366 1683-0113 21.9 µM -0.892688344862594 0.202278445175022 no 2699 0.186012046823945 911 708623 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.892835395411589 0.202237614411116 no 2700 0.185972664149424 928 442882 SGTC_2420 aureobasidin a 50 nM -0.893254456832334 0.202121282846545 no 2701 0.18586046063187 892 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1491 4138-0063 26.5 µM -0.894276894609348 0.201837621913768 no 2702 0.185586879574451 904 23883227 SGTC_476 mead acid 10 µM -0.894407139377742 0.201801504464459 no 2703 0.185552046994339 917 5312531 An omega 9 fatty acid. SGTC_721 1187-1332 279 µM -0.894545511934641 0.201763137383634 no 2704 0.185515045168691 921 25730 SGTC_3242 9133940 49.47 µM -0.896099339118423 0.201332601873573 no 2705 0.185099855004847 900 17248444 SGTC_2522 biochanin a 4.94 µM -0.897357146050602 0.200984491515952 no 2706 0.18476418597751 901 5280373 A possible chelator. SGTC_3054 9094397 49.47 µM -0.901276460436808 0.199902100780611 no 2707 0.183720673165762 914 2598354 SGTC_888 0916-0002 6.97 µM -0.901552909834843 0.199825886776576 no 2708 0.183647207729241 905 2802138 YIL048W NEO1 SGTC_2589 lobaric acid 100 µM -0.905272214680147 0.198802216284544 no 2709 0.18266059628119 930 73157 A novel microtubule depolymerizer. SGTC_951 1171-0579 82.7 µM -0.905595131277997 0.198713488813718 no 2710 0.182575093365516 895 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_3067 9117431 49.47 µM -0.905704306296261 0.198683496305043 no 2711 0.182546191301066 950 17150885 SGTC_1430 4049-0248 69.1 µM -0.907440386607962 0.198206928083699 no 2712 0.182086980258829 904 22774488 SGTC_2046 4110841 106 µM -0.907487595177796 0.198193978590506 no 2713 0.182074503202553 900 44119630 YMR134W ERG29 SGTC_278 4092-0821 23.9 µM -0.909131659127035 0.197743324163531 no 2714 0.181640316456879 910 877900 SGTC_707 0865-0008 204 µM -0.909197266887861 0.197725353275464 no 2715 0.181623003322076 923 723043 SGTC_3286 9117135 37.221 µM -0.909262454134812 0.197707498549583 no 2716 0.181605802178853 890 3438150 SGTC_2231 micatex 6.853 µM -0.913223172766092 0.19662449037178 no 2717 0.180562589459519 925 20737 An antifungal of unknown mechanism. SGTC_1127 asiatic acid 681.4 nM -0.913837326832226 0.196456880174734 no 2718 0.180401164800812 927 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1312 1218-2183 165 µM -0.913900912121908 0.196439531914993 no 2719 0.180384457175307 887 6744073 SGTC_1468 k284-1086 134 µM -0.915635710631012 0.195966577341623 no 2720 0.179928997371209 904 15996457 SGTC_2185 6113692 200 µM -0.918753410275253 0.195118343515297 no 2721 0.179112283195927 910 874150 SGTC_876 0720-0963 56.8 µM -0.918837332524378 0.195095541641683 no 2722 0.179090331162724 922 765861 SGTC_719 2810-4230 27.3 µM -0.919274060868642 0.194976907666049 no 2723 0.178976120901909 912 721079 SGTC_1234 0326-0494 15.5 µM -0.919411117915238 0.194939686192615 no 2724 0.178940288115134 916 1547813 SGTC_2359 9039622 200 µM -0.920686356487196 0.194593568525806 no 2725 0.178607100689185 914 6463596 SGTC_2035 5154463 94.595 µM -0.922548110829292 0.194088934248138 no 2726 0.178121373659298 911 2769623 SGTC_1928 4'-methoxychalcone 40.3 µM -0.92266618447721 0.19405695692698 no 2727 0.178090596647013 898 641818 SGTC_2084 5306078 60.6385 µM -0.923148784072335 0.193926290161553 no 2728 0.177964837358982 930 679340 SGTC_1791 st048313 56.1 µM -0.925002896383467 0.193424776931004 no 2729 0.177482200421553 864 1204976 SGTC_1444 4112-3581 28 µM -0.927173830655079 0.192838574165079 no 2730 0.176918143876246 913 2877249 SGTC_2217 6934799 96.0675 µM -0.927332157830213 0.192795864646841 no 2731 0.176877051359537 910 675606 SGTC_2307 7538926 6.34 µM -0.927560016537139 0.192734408806992 no 2732 0.176817923094106 915 96582 SGTC_146 3448-8650 53.125 µM -0.92767801756659 0.192702587419083 no 2733 0.176787307291677 940 2891488 YIL048W NEO1 SGTC_1770 st043884 66.3 µM -0.928674053273141 0.192434113983374 no 2734 0.176529015688487 937 670149 SGTC_916 4466-0038 42 nM -0.92988621327859 0.192107694661541 no 2735 0.176215000972502 921 5722064 YGL116W CDC20 SGTC_1862 st057513 3.81 µM -0.930622392142694 0.191909616483159 no 2736 0.176024463660106 916 5393163 SGTC_1144 3486-0183 12.5 µM -0.931261812500775 0.191737673885833 no 2737 0.175859075211492 930 6744069 SGTC_2332 7982454 138.89 µM -0.931517446826117 0.191668959235187 no 2738 0.175792981992664 922 2981748 SGTC_29 0299-0004 12.984 µM -0.931522142106347 0.191667697282283 no 2739 0.175791768194162 900 16871 A napthoquinone isolated from Swertia calycina. SGTC_1022 4477-0945 21.3 µM -0.933483752716979 0.191140919415678 no 2740 0.175285127669734 889 4648966 SGTC_670 4204-0025 119 µM -0.933664290243282 0.19109248187891 no 2741 0.175238545404331 918 719039 SGTC_891 0929-0073 133 µM -0.936529163651699 0.190324854909989 no 2742 0.174500402146474 922 5603632 SGTC_212 3807-4682 38.772 µM -0.936727884093303 0.190271679207373 no 2743 0.174449274570868 912 3125501 YBL034C STU1 SGTC_588 3970-1144 52.9 µM -0.93720109599922 0.190145088944764 no 2744 0.174327563066013 891 1888707 SGTC_1655 st012546 55.1 µM -0.937842760117797 0.189973518239817 no 2745 0.174162611355267 923 720985 YLR208W SEC13 SGTC_2966 9084041 48.03 µM -0.939176297895638 0.189617256123764 no 2746 0.173820118066385 924 17741380 SGTC_3135 9127742 49.47 µM -0.939620089359616 0.189498785947342 no 2747 0.173706233910065 909 3643468 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.939671778590972 0.189484990463767 no 2748 0.173692972693931 898 17037758 SGTC_2301 7769476 200 µM -0.940467535373576 0.189272686709974 no 2749 0.173488897285768 913 977820 SGTC_1084 voriconazole 435 nM -0.941755222426326 0.188929448894989 no 2750 0.173158987562617 920 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3126 9127922 49.47 µM -0.941839718106136 0.188906939670025 no 2751 0.173137353465597 923 45595682 SGTC_1017 4239-0030 168 µM -0.942578018961142 0.188710330329333 no 2752 0.172948393703694 891 1149593 SGTC_1903 st060211 78.3 µM -0.944444708622501 0.188213794193014 no 2753 0.172471221943366 900 688960 SGTC_1210 3013-0140 750 nM -0.945090793740222 0.188042124669444 no 2754 0.172306262496129 917 905973 SGTC_2746 daunorubicin 9.88 µM -0.94528654573556 0.187990131022225 no 2755 0.172256302671049 869 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_658 3253-0951 102 µM -0.945500400692125 0.187933339196521 no 2756 0.172201733173748 926 1184878 SGTC_128 0906-2981 13.371 µM -0.946216443511259 0.187743262304354 no 2757 0.172019100414655 910 6740226 SGTC_2770 toltrazuril 17.5 µM -0.946890111409582 0.187564542485363 no 2758 0.171847388669903 876 68591 Kills coccidiodes. SGTC_3173 9105693 49.47 µM -0.947294755267198 0.187457243591106 no 2759 0.171744301314058 931 17096658 SGTC_2730 imipramine 71.33 µM -0.950305160451297 0.186660169805772 no 2760 0.170978608770161 900 3696 A tricyclic antidepressant. SGTC_1716 st033144 30.6155 µM -0.951751565967313 0.186277948186081 no 2761 0.170611495371722 913 674617 SGTC_530 4358-1714 28 µM -0.951776743982907 0.186271299036735 no 2762 0.170605109390332 890 1564641 SGTC_372 0155-0182 15.9 µM -0.952260459791681 0.18614358524988 no 2763 0.170482452699798 839 771486 SGTC_747 3448-8087 38.7 µM -0.952557131989793 0.186065282788393 no 2764 0.170407252940629 953 5168703 SGTC_97 0535-0701 19.132 µM -0.952794133638262 0.186002744204377 no 2765 0.17034719359708 903 2832013 YGL099W LSG1 SGTC_2694 st077685 81.9 µM -0.953152223687496 0.185908278257912 no 2766 0.17025647457906 917 2838096 SGTC_1240 0356-0016 42.1 µM -0.954533512764465 0.18554416608246 no 2767 0.169906826973201 872 4305613 SGTC_2394 5221648 200 µM -0.954913196697264 0.18544415779257 no 2768 0.169810797776737 932 788586 SGTC_1114 scopoletin 1.73284 µM -0.956714072062914 0.18497026525898 no 2769 0.1693557967192 927 5280460 A coumarin with genotoxic properties. SGTC_257 daunorubicin 18.5 µM -0.957110421358541 0.184866068778394 no 2770 0.169255762049348 894 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1077 5-fluorocytosine 377 nM -0.958509757106509 0.184498488477424 no 2771 0.168902886898587 932 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2482 5981709 142.65 µM -0.959592024702864 0.184214508255072 no 2772 0.168630292246079 930 877755 SGTC_2475 5812728 15.03 µM -0.962409369644371 0.183476531331867 no 2773 0.167922004464794 914 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2991 9074669 71.4286 µM -0.962564086871122 0.183436058063956 no 2774 0.167883163704319 911 17333109 SGTC_2371 9071574 200 µM -0.963402191565318 0.183216910730932 no 2775 0.16767286346356 939 45596039 SGTC_1877 wortmannin 25 µM -0.964301694479546 0.182981890760615 no 2776 0.167447345802917 921 312145 A covalent inhibitor of PI 3-kinase. SGTC_1889 st059080 5.18 µM -0.964701443393868 0.182877505723378 no 2777 0.167347186047652 923 176925 Isolated from Daphnopsis sellowiana. SGTC_2155 5570423 76 µM -0.965341369010627 0.182710481568861 no 2778 0.167186928810856 937 797402 SGTC_2883 9059145 45.46 µM -0.966131707174417 0.182504330397809 no 2779 0.166989140198932 946 16476510 SGTC_917 harmaline 728.087 nM -0.968114157135428 0.181987869335028 no 2780 0.166493680118605 889 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1689 st020265 53.493 µM -0.969622863427933 0.181595439370322 no 2781 0.16611725611827 936 5758320 YPR016C TIF6 SGTC_2794 7785382 27.27 µM -0.969933742832533 0.181514642304372 no 2782 0.166039759712481 893 2205081 SGTC_52 0329-0193 875 nM -0.969997464183522 0.181498084005105 no 2783 0.166023878059895 922 3739292 SGTC_2889 9059656 51.95 µM -0.970025871046101 0.181490702650064 no 2784 0.166016798364346 925 3949838 SGTC_965 1291-5240 308 µM -0.972995390655178 0.180720127275939 no 2785 0.165277796484911 944 2834598 SGTC_2014 4013930 200 µM -0.977391159577237 0.179583219379377 no 2786 0.164187768974219 935 64556 SGTC_1034 k072-0165 12.7 µM -0.97763572685823 0.179520097542631 no 2787 0.164127260365379 950 5835461 SGTC_939 1165-0479 45.3 µM -0.978874907707003 0.17920048430241 no 2788 0.163820895866578 914 1377347 SGTC_2002 4023503 131 µM -0.979219715850732 0.179111614040701 no 2789 0.163735714491765 941 4736863 YCR052W RSC6 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.98066614813973 0.178739115228822 no 2790 0.163378701311204 925 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_452 diindolylmethane 8 µM -0.981067084654674 0.178635948691129 no 2791 0.163279830416527 924 3071 Inhibits expression of several cancer promoting factors. SGTC_992 3909-8734 162 µM -0.981172460278614 0.178608840302439 no 2792 0.163253851253355 934 4288319 SGTC_1396 3511-0007 98.6 µM -0.982415657050462 0.178289217518781 no 2793 0.162947557977552 898 X1396 SGTC_2116 5511452 16.8835 µM -0.982577808152026 0.178247555463697 no 2794 0.162907635473422 937 870744 SGTC_1938 st074717 56.4 µM -0.986569830320074 0.177223806566325 no 2795 0.16192678322574 874 17250979 SGTC_2528 xanthyletin 44.79 µM -0.986734794491906 0.177181581770611 no 2796 0.161886333964335 949 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1771 st048882 4.1505 µM -0.989216985522644 0.176546998930863 no 2797 0.161278494863416 937 4580403 SGTC_1105 epirubicin 18.1 µM -0.989791640033349 0.176400291190224 no 2798 0.161137985928105 921 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2798 7813637 45.45 µM -0.99128821607487 0.17601858149006 no 2799 0.16077243268907 912 956368 SGTC_3237 9133362 49.47 µM -0.991509528046307 0.175962179109861 no 2800 0.160718421083224 938 43845137 SGTC_2065 5221596 34.26 µM -0.992298697304876 0.175761148849598 no 2801 0.160525919302779 916 788581 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.995386337728043 0.174976012891575 no 2802 0.159774200404794 947 61125 An anti-inflammatory. SGTC_1540 guanosine 70.6 µM -0.995551807907781 0.174933999478971 no 2803 0.159733980053241 907 6802 Guanosine is a purine nucleoside SGTC_249 wiskostatin 11.211 µM -0.997477210198222 0.17444560430378 no 2804 0.159266465214299 896 2775510 A n-wasp and actin depolymerizer. SGTC_1926 methyl fluorone black 53.6 µM -0.998131980843666 0.174279713532848 no 2805 0.159107682057771 865 72721 Reacts with homocysteine. SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.999380712387657 0.173963616555526 no 2806 0.158805149803659 937 165506 SGTC_2096 5468907 200 µM -0.99938731376198 0.173961946489475 no 2807 0.158803551480392 921 759785 SGTC_2360 9040895 200 µM -1.0007316016341 0.173622070704324 no 2808 0.15847829251031 941 4914414 SGTC_1581 himbacine 57.9 µM -1.00321200399904 0.172996061387883 no 2809 0.157879291196821 957 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1726 st035556 14.5795 µM -1.00518366393066 0.172499476758074 no 2810 0.157404209921607 918 5919439 SGTC_2691 st077356 60.2 µM -1.00576735404245 0.172352642436779 no 2811 0.157263747333169 942 2839272 SGTC_3213 9129884 49.47 µM -1.00602030492745 0.172289034347832 no 2812 0.157202901361989 933 17190742 SGTC_1809 st050081 57.6 µM -1.00704302807052 0.172032008827005 no 2813 0.156957048664357 917 5036894 SGTC_1720 st037298 9.481 µM -1.01039768082371 0.17119065401802 no 2814 0.156152399275271 959 597396 SGTC_2709 st078560 56 µM -1.0107826058182 0.171094282482979 no 2815 0.156060245030771 939 17250903 SGTC_2297 7971671 152.32 µM -1.01084776166748 0.171077973208968 no 2816 0.156044649726194 939 909016 SGTC_3260 9137109 49.47 µM -1.01140993135143 0.170937296840735 no 2817 0.155910134899578 916 17478346 SGTC_864 0469-0573 172 µM -1.01209779138727 0.170765268645175 no 2818 0.155745649154527 957 689425 SGTC_1166 k206-0078 225 µM -1.01287525917105 0.170570963723382 no 2819 0.155559873610394 927 5404595 SGTC_1608 st001473 40.5 µM -1.01333032392004 0.170457299541272 no 2820 0.155451203960187 943 7292267 SGTC_623 k072-0108 16.9 µM -1.01364040506383 0.17037987655519 no 2821 0.155377185154467 939 5382803 SGTC_326 k292-0812 17.5 µM -1.01378131522274 0.170344700676144 no 2822 0.155343556479346 910 3579357 SGTC_814 3342-0569 96 µM -1.0141963368035 0.170241124466446 no 2823 0.155244538116316 913 4346283 SGTC_1348 1493-0373 93.8 µM -1.01585447720277 0.169827708016822 no 2824 0.154849344744569 944 3010129 SGTC_3258 9138477 49.47 µM -1.01652116369964 0.169661667772126 no 2825 0.154690637299397 950 4970355 SGTC_430 0958-0115 16.4 µM -1.02102965205694 0.168541549793499 no 2826 0.153620195184515 937 6833180 SGTC_3057 9095946 49.47 µM -1.02338708497289 0.16795775121898 no 2827 0.153062431671149 957 24540043 SGTC_2487 5918373 44.05 µM -1.0260231823277 0.167306487106863 no 2828 0.152440328466071 929 2876279 SGTC_487 nimodipine 119 µM -1.02657890326011 0.167169400820568 no 2829 0.152309396113089 931 4497 L-type voltage-gated calcium channels inhibitor SGTC_2202 7226349 200 µM -1.02839736442693 0.166721325724481 no 2830 0.151881473892459 928 844334 SGTC_1426 4048-4480 71.7 µM -1.02946153916024 0.16645946919609 no 2831 0.151631422006382 939 14224343 SGTC_382 3229-0966 23.2 µM -1.03005771377403 0.166312887386957 no 2832 0.15149145697384 946 5722370 SGTC_1670 st016595 4.04 µM -1.03068449726187 0.166158869670539 no 2833 0.151344398494428 944 597879 SGTC_1112 tnp00069 1.16933 µM -1.0311262190809 0.166050381995449 no 2834 0.151240816982896 933 145826 SGTC_1012 4112-3522 18 µM -1.0319597609303 0.165845787313105 no 2835 0.151045484155904 924 3112398 SGTC_2069 5228469 200 µM -1.03258082227709 0.165693452419342 no 2836 0.150900053358459 952 2835210 SGTC_3347 9188721 44.724 µM -1.03300259370579 0.165590051267851 no 2837 0.150801342432361 944 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2652 actinonin 100 µM -1.03501077878173 0.165098298718662 no 2838 0.150331938711291 937 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1324 1418-0026 34.4 µM -1.03655661130928 0.16472040896239 no 2839 0.149971271586998 952 1372513 SGTC_2136 5328288 199.296 µM -1.03705653266976 0.164598319637318 no 2840 0.149854755617513 951 262395 SGTC_435 c-PAF 6.7 µM -1.03956713972567 0.163986073526012 no 2841 0.149270525109451 920 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.03970967945479 0.163951357631307 no 2842 0.149237401105409 954 688798 SGTC_2750 bromebric acid 70.15 µM -1.04257224505855 0.163255182489574 no 2843 0.148573224683544 953 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.04410726064602 0.162882659439862 no 2844 0.148217883513545 947 6708784 An antioxidant flavonoid SGTC_1015 4130-4525 82 µM -1.04915558290493 0.161661415890819 no 2845 0.147053258843184 941 1363237 SGTC_2695 st077686 51.995 µM -1.05115572164431 0.161179215802432 no 2846 0.146593537806396 950 2876092 SGTC_3326 9140064 16.379 µM -1.05148739284643 0.161099346205974 no 2847 0.146517398314164 955 1868434 SGTC_3349 9149703 23.001 µM -1.05220266212964 0.160927190442007 no 2848 0.146353289192953 939 4910494 SGTC_1436 4092-1007 8.32 µM -1.05355946852107 0.160600955341102 no 2849 0.14604232704875 916 2881121 SGTC_3265 9137266 49.47 µM -1.05527128448974 0.160189977280549 no 2850 0.145650635116645 909 17224265 SGTC_870 0573-2213 57.6 µM -1.05539492494913 0.16016031994231 no 2851 0.145622371500788 931 3916321 SGTC_1259 0671-0132 43 µM -1.05578673277324 0.160066361658395 no 2852 0.145532830471907 939 X1259 SGTC_1626 st003712 1.76 µM -1.05687318417916 0.159806011508031 no 2853 0.14528473415255 960 24207035 SGTC_2967 9089538 49.85 µM -1.05763898368898 0.159622666838609 no 2854 0.145110031280811 954 728216 SGTC_1989 st071868 50.2 µM -1.0586739512938 0.159375097845262 no 2855 0.144874147477999 932 16414057 SGTC_909 3448-9333 149 µM -1.05897297885278 0.159303615920032 no 2856 0.144806042954058 949 3344074 SGTC_3052 9092717 49.47 µM -1.0604723239642 0.158945517140972 no 2857 0.144464887200354 955 25237534 SGTC_309 k408-0051 1.48 µM -1.06051702924615 0.158934847979668 no 2858 0.144454723438385 925 3640463 SGTC_2942 9052777 62.25 µM -1.06120273927806 0.158771258319128 no 2859 0.144298887392509 960 6469503 SGTC_2768 sulfasalazine 50.2 µM -1.06150204989788 0.158699886481406 no 2860 0.144230900909173 960 5384001 An antioxidant and salicylic acid derivative. SGTC_2679 rapamycin 1 nM -1.06395595032817 0.158115537194724 no 2861 0.143674327493803 901 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2721 ifenprodil 61.44 µM -1.06408424423155 0.158085025361696 no 2862 0.143645268854445 959 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_235 0330-0087 5 mM -1.06543016957112 0.157765160122955 no 2863 0.143340655110007 955 46494818 YHR062C RPP1 SGTC_823 0417-1665 178 µM -1.06653025307695 0.157504036248186 no 2864 0.143092005196205 968 3429856 SGTC_1728 st035614 33.7865 µM -1.06662677691233 0.157481138205408 no 2865 0.143070201999886 936 15945546 SGTC_2436 5633522 8.09 µM -1.06684704086283 0.157428893881042 no 2866 0.143020456288685 957 5724242 SGTC_2225 6654152 15.4 µM -1.06870188345609 0.156989396377937 no 2867 0.142602011291877 916 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1111 tnp00062 510.699 nM -1.07211401242292 0.156183016162221 no 2868 0.141834412910142 936 676306 SGTC_1649 st011737 51.3 µM -1.07429645474138 0.155668678320978 no 2869 0.141344916749519 890 1761035 SGTC_898 1000-0849 28.3 µM -1.07509733270679 0.155480215301515 no 2870 0.141165576767203 940 6751807 SGTC_995 3931-2021 34.6 µM -1.07847043922747 0.154688106932996 no 2871 0.140411933459919 966 730143 SGTC_1600 coumarin 106 71.1 µM -1.07858440049441 0.154661391998098 no 2872 0.140386519226289 950 100336 A hepatotoxic, DNA x-linker. SGTC_1718 roemerine 11.9335 µM -1.08004012531137 0.154320407487901 no 2873 0.140062156241384 889 235224 An aporphine alkaloid with mutagenic activity. SGTC_2291 7917025 104.35 µM -1.08119318970202 0.154050670313109 no 2874 0.139805593392178 941 2964612 SGTC_2523 spermine 47.74 µM -1.08311985153866 0.153600661374218 no 2875 0.139377614322504 925 1103 A DNA binding polyamine. SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.08663000002709 0.152783038394077 no 2876 0.13860018061613 946 688761 SGTC_3224 9130643 49.47 µM -1.09133320459245 0.151692048341003 no 2877 0.137563146039297 965 17644395 SGTC_1502 4534-4282 27.7 µM -1.09199543793641 0.15153884868419 no 2878 0.137417553200233 979 3278949 SGTC_4 0960-0234 25.671 µM -1.09200426504161 0.151536807335313 no 2879 0.137415613260799 925 6821112 SGTC_1183 1254-0324 198 µM -1.09225527852378 0.151478765821415 no 2880 0.137360455668664 930 5799357 SGTC_3064 1327-0027 10 µM -1.09587284049983 0.150643923407036 no 2881 0.136567213084543 916 16000455 YPR107C YTH1 SGTC_3061 glucosamine 200 µM -1.09747527662178 0.150275102505019 no 2882 0.136216841304426 920 91431 and experimental redox chemotherapeutic SGTC_2422 chlorphenesin carbamate 384.24 µM -1.09830467352809 0.150084442873753 no 2883 0.136035735920808 950 2724 A muscle relaxant with antifungal properties. SGTC_108 0509-0257 621.132 µM -1.10305841407609 0.148994777225478 no 2884 0.135000899333659 948 536624 SGTC_1384 3089-0840 101 µM -1.10453094219857 0.148658315069241 no 2885 0.134681444418072 942 1069836 SGTC_2270 7924575 90.91 µM -1.10859994722194 0.147731219216256 no 2886 0.133801400456553 949 1262135 SGTC_3273 9137859 49.47 µM -1.10903333301319 0.147632703787075 no 2887 0.13370790128255 1010 2377234 SGTC_539 4859-0462 2.54 µM -1.10950293937116 0.147526004535383 no 2888 0.133606638557514 942 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2439 5492030 7.2 µM -1.11038109850673 0.147326616678181 no 2889 0.133417419825796 938 5722370 SGTC_2956 9076196 2.52 µM -1.11053137953106 0.147292513165836 no 2890 0.13338505694944 971 16423868 SGTC_1480 1070-0044 41.2 µM -1.11062733847142 0.147270739818684 no 2891 0.133364395107679 951 3124987 SGTC_779 1360-0071 233 µM -1.11381056771956 0.146549679077945 no 2892 0.13268023120384 944 7566 SGTC_1371 2421-0008 32.7 µM -1.11407428149972 0.146490049458573 no 2893 0.132623660460255 942 2827552 SGTC_103 0844-0104 51.839 µM -1.11638909420294 0.145967334731706 no 2894 0.132127809836328 957 5375804 SGTC_1646 st011709 75.6 µM -1.11741796607921 0.145735404924528 no 2895 0.131907828447812 963 5757843 SGTC_3336 9143619 71.43 µM -1.11793098829677 0.145619851310309 no 2896 0.131798234461416 978 45595730 SGTC_3101 9120531 49.47 µM -1.12067706315832 0.145002370381904 no 2897 0.1312126744679 974 24824904 SGTC_101 0490-5701 117.494 µM -1.12424373252412 0.144203005863201 no 2898 0.130454820721178 931 4661669 SGTC_1394 3474-0001 65.7 µM -1.12523094130739 0.143982277867532 no 2899 0.130245592423478 940 5017666 YIL048W NEO1 SGTC_2219 9098279 200 µM -1.12550563535123 0.143920900133285 no 2900 0.130187415283954 942 902349 SGTC_1686 st019653 115.5 µM -1.12601762607494 0.143806547854141 no 2901 0.130079029346507 985 97252 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.13041650014391 0.142826592720255 no 2902 0.129150382326386 959 5355888 SGTC_1615 st002656 86.5 µM -1.13047263864902 0.142814115755811 no 2903 0.129138560695879 970 1584458 SGTC_1305 1181-0477 144 µM -1.13135057971663 0.142619086366372 no 2904 0.128953781715153 976 6252086 SGTC_2958 9077254 16.72 µM -1.13153346242854 0.14257848273452 no 2905 0.128915313744173 966 16457351 SGTC_2529 gangaleoidin 93.61 µM -1.13672457511308 0.141429211255207 no 2906 0.1278267212883 974 4565183 SGTC_1308 1187-1617 41.4 µM -1.13735750841238 0.141289515416416 no 2907 0.127694431438035 959 2882570 SGTC_3043 9092303 49.47 µM -1.13903704997365 0.140919274341748 no 2908 0.127343850664124 957 25236084 SGTC_1611 st001856 99.4 µM -1.14023463158933 0.140655679650753 no 2909 0.127094281511438 976 647478 SGTC_1421 4029-0249 71.4 µM -1.14118067903572 0.14044768582925 no 2910 0.126897371422519 964 2894095 SGTC_1808 st050063 61.5 µM -1.14153193105306 0.140370514295648 no 2911 0.126824316002988 976 4011993 SGTC_3217 9129673 49.47 µM -1.14271638732864 0.140110496594721 no 2912 0.12657818183239 974 17248312 SGTC_994 3910-0338 138 µM -1.14523551639818 0.139558573533779 no 2913 0.126055804820266 965 3479481 SGTC_2277 7947813 106.88 µM -1.14769004862821 0.139022227171154 no 2914 0.12554827037844 977 1246798 SGTC_2273 7815444 169.05 µM -1.14827684289142 0.138894213303403 no 2915 0.12542714784027 973 2824616 SGTC_2347 9049783 174.81 µM -1.14902182779149 0.138731804553549 no 2916 0.125273490082649 989 6467988 YPL169C MEX67 SGTC_2342 7990637 118.86 µM -1.14902869871145 0.138730307276405 no 2917 0.125272073524706 995 2033102 YER133W GLC7 SGTC_170 4197-0004 226 µM -1.15096409404971 0.138308993586284 no 2918 0.124873503758455 967 218692 SGTC_3015 9080845 49.47 µM -1.15458099562628 0.137523975069357 no 2919 0.124131026385382 975 5296973 SGTC_489 paxilline 115 µM -1.1549996293825 0.137433310874609 no 2920 0.124045289118501 979 105008 A toxic potassium channel blocker. SGTC_1439 4092-1168 46 µM -1.15622190264805 0.137168834720448 no 2921 0.12379520155696 982 2886240 SGTC_2036 5160441 105 µM -1.15795460554761 0.136794507647833 no 2922 0.123441280907745 937 134534 YIL048W NEO1 SGTC_294 k038-0071 157 µM -1.16135683872758 0.136061534355826 no 2923 0.122748406849333 973 24152826 SGTC_1450 4112-4260 37.6 µM -1.16197008656075 0.135929703426861 no 2924 0.122623807968799 955 1633175 SGTC_629 3448-6466 76.7 µM -1.16393302853989 0.135508314577192 no 2925 0.12222557666676 971 573744 SGTC_1519 esterone 74 µM -1.16442006793098 0.135403899563186 no 2926 0.122126909428623 973 698 A steroid. SGTC_3244 9134489 49.47 µM -1.16633914352836 0.134993011079313 no 2927 0.121738676458299 976 16584271 SGTC_3095 9117207 49.47 µM -1.16758544735859 0.134726626566757 no 2928 0.121487011542159 969 17015229 SGTC_1779 st039427 55 µM -1.16886165124593 0.13445422525691 no 2929 0.121229688157892 969 1124498 SGTC_2188 6126565 140.678 µM -1.17141087492888 0.133911234922357 no 2930 0.120716831553027 951 874518 SGTC_875 0709-0210 25.7 µM -1.17161588742435 0.133867632368415 no 2931 0.120675653286854 975 6251364 SGTC_1447 4239-0816 81.9 µM -1.17216997332865 0.133749836864811 no 2932 0.120564410543784 958 1341554 SGTC_54 0159-0055 9 µM -1.17267415229299 0.133642713227181 no 2933 0.120463250281244 971 3319099 SGTC_1058 3448-5425 97.3 µM -1.17391721369954 0.133378850240749 no 2934 0.120214093434851 964 7279705 SGTC_3322 9139058 2.11 µM -1.17563370152059 0.13301508311846 no 2935 0.119870641098508 968 4908926 YPR165W RHO1 SGTC_2860 9025725 38.96 µM -1.17749000611563 0.132622454593978 no 2936 0.119499992056071 987 40546248 SGTC_204 PMA1.184 62.41 µM -1.1775524004212 0.1326092714056 no 2937 0.119487547821997 975 2252213 YGL008C PMA1 SGTC_1822 st052468 42 µM -1.17814699696303 0.132483685390912 no 2938 0.119369004365986 968 2873678 SGTC_3063 1327-0034 4 µM -1.18021605199173 0.132047314704011 no 2939 0.118957148158793 950 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_367 0335-0881 7.1 µM -1.18247150937487 0.131572761408458 no 2940 0.118509331883463 983 23828853 SGTC_1792 st045773 43.6 µM -1.18704708265294 0.130613670116167 no 2941 0.117604524757313 913 2919270 SGTC_1893 st059353 36.1 µM -1.18906169180772 0.130192922004674 no 2942 0.117207695775898 998 3112488 SGTC_520 3584-0023 682 µM -1.18935488016603 0.130131768316776 no 2943 0.117150023962117 963 1340790 SGTC_2996 9066192 71.4286 µM -1.18984354856643 0.130029885278108 no 2944 0.117053944799027 961 6472854 SGTC_3294 9122953 26.2835 µM -1.19165393917533 0.129652916077877 no 2945 0.116698482872425 980 16459826 SGTC_1427 4048-4900 550 nM -1.19391404429099 0.129183368199542 no 2946 0.116255796598523 964 24132586 SGTC_1962 st076595 64.5 µM -1.19601585797236 0.128747765218573 no 2947 0.115845185375631 966 279619 SGTC_1843 st055809 45.5 µM -1.1962928951607 0.128690425087534 no 2948 0.115791140184305 976 16413835 SGTC_2715 st079500 56.4 µM -1.19652033166467 0.128643364368866 no 2949 0.115746784619686 968 28246688 SGTC_550 4123-0385 25.7 µM -1.19660767103378 0.128625295450513 no 2950 0.115729754558509 992 5731123 SGTC_2878 9043973 25.97 µM -1.19787769755609 0.128362749177937 no 2951 0.11548231668452 1000 6465167 SGTC_1294 1000-1494 117 µM -1.20022270223953 0.127878956252095 no 2952 0.115026430330765 967 712797 YDL207W GLE1 SGTC_2197 6588183 93.1375 µM -1.20245132193943 0.127420350103546 no 2953 0.114594357590476 959 884136 SGTC_34 0469-0683 81.75 µM -1.20489822093343 0.126918145120976 no 2954 0.114121297753286 979 3690923 SGTC_1987 st072290 61.9 µM -1.20550330952341 0.126794168666077 no 2955 0.114004530588382 986 54697379 SGTC_282 k297-0036 65.7 µM -1.20714652792843 0.126457915539874 no 2956 0.113687859501921 991 5061378 SGTC_2195 6536160 144.242 µM -1.20855740958788 0.126169701782304 no 2957 0.113416463668806 977 3834386 SGTC_2684 capsaicin 100 µM -1.2088074706501 0.126118667317497 no 2958 0.113368410408552 971 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3266 9136860 49.47 µM -1.2088329969218 0.126113458521057 no 2959 0.113363505941306 938 4871271 YPR165W RHO1 SGTC_2449 5812982 45.77 µM -1.21325788203226 0.12521279818718 no 2960 0.112515620178871 986 776185 SGTC_1751 st044839 27.194 µM -1.21530137328036 0.12479837674564 no 2961 0.1121255841711 968 5291326 SGTC_1920 st075728 45.7 µM -1.21747340401357 0.12435893923761 no 2962 0.111712074768973 965 3400306 SGTC_2952 9073731 13.78 µM -1.21776103977193 0.124300827036372 no 2963 0.111657396816216 991 16457353 SGTC_1820 st053765 18.6 µM -1.22080349012448 0.123687311424007 no 2964 0.111080216028846 971 3690829 SGTC_2292 7671323 168.05 µM -1.22193083959949 0.123460518639622 no 2965 0.110866890953784 985 937504 SGTC_977 1348-1378 135 µM -1.22435605106684 0.122973618240433 no 2966 0.11040897042687 967 X977 SGTC_169 k015-0017 16.025 µM -1.22527193754278 0.122790089900956 no 2967 0.110236388985941 1000 1840002 SGTC_878 0828-0289 13.7 µM -1.2273163060453 0.122381125783011 no 2968 0.10985186462745 962 745350 YLR208W SEC13 SGTC_1193 1488-0126 41.5 µM -1.22840700314814 0.122163329611922 no 2969 0.109647110130578 960 1384710 SGTC_1273 0849-0096 14.1 µM -1.22896516672999 0.122051977883617 no 2970 0.109542433195047 993 5286025 SGTC_1313 1220-0047 237 µM -1.23202933341033 0.121441956799575 no 2971 0.108969063411151 986 3528706 SGTC_1743 st037606 46.3785 µM -1.23351700289021 0.121146562496569 no 2972 0.108691468543645 966 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2944 9067346 25.62 µM -1.23377891024238 0.121094610071268 no 2973 0.108642650077227 966 6473075 SGTC_3110 9122132 49.47 µM -1.23407270094215 0.121036351859327 no 2974 0.10858790745367 987 918317 SGTC_2074 5212007 75.395 µM -1.23445819748378 0.120959938445926 no 2975 0.108516107194022 962 758611 SGTC_2440 5628896 157.78 µM -1.23476787432693 0.120898578661559 no 2976 0.108458453397051 984 5522048 SGTC_1604 st002052 72.4 µM -1.23564141130941 0.120725612922081 no 2977 0.108295942233914 976 6254834 YHR062C RPP1 SGTC_1752 st044819 83.042 µM -1.23882652389972 0.120096416658932 no 2978 0.107704874474246 977 441209 YML126C ERG13 SGTC_479 n-linoleoylglycine 10 µM -1.23899327293707 0.120063540354712 no 2979 0.107673994666138 995 6433346 An anti-infammatory. SGTC_352 k048-0007 5.11 µM -1.23922727546012 0.120017415024235 no 2980 0.107630671122086 978 6811911 SGTC_1251 0490-5699 265 µM -1.2427952423522 0.119315663093138 no 2981 0.106971648082418 980 3883818 SGTC_1505 k297-0037 20.6 µM -1.24315288138629 0.119245482231018 no 2982 0.106905751050353 975 4089396 SGTC_1355 1499-0035 1.68 µM -1.24367485002262 0.119143106649106 no 2983 0.10680962792219 993 1548538 SGTC_1756 st041558 35.5 µM -1.24706292289249 0.118480100113036 no 2984 0.106187213302133 996 3955792 SGTC_1011 4112-3381 17.4 µM -1.24884903043903 0.118131631187957 no 2985 0.105860148456119 974 2877139 SGTC_56 0957-0365 83.25 µM -1.24961776602883 0.117981874490235 no 2986 0.105719605031515 978 6752360 SGTC_478 N-arachidonylglycine 10 µM -1.24982012453383 0.117942475548385 no 2987 0.105682631449863 983 5283389 SGTC_497 capsazepine 133 µM -1.25047093369564 0.11781582694616 no 2988 0.10556378337356 988 2733484 A calcium channel blocker. SGTC_2802 7925815 54.55 µM -1.25176883927683 0.117563539646819 no 2989 0.105327053865259 977 1262923 SGTC_1228 0124-0032 52.5 µM -1.25189358974209 0.117539310773767 no 2990 0.105304320441895 977 X1228 SGTC_517 1365-0151 113 µM -1.25404919651489 0.117121209829015 no 2991 0.104912062181988 982 768657 SGTC_2090 5301565 104.445 µM -1.2542064076752 0.117090758470237 no 2992 0.104883495728705 983 2056344 SGTC_2872 9044037 25.97 µM -1.25831857987115 0.116296233944532 no 2993 0.104138282172256 992 6465195 SGTC_3306 9127676 59.7925 µM -1.25845129534387 0.116270655485809 no 2994 0.10411429539633 975 41905287 SGTC_2133 5320837 200 µM -1.26043018609036 0.115889734254298 no 2995 0.103757108983457 1003 2841355 SGTC_1442 4112-3290 3 µM -1.26112982432836 0.115755271538814 no 2996 0.103631038421385 1005 704353 SGTC_2890 9046729 58.44 µM -1.26264789141686 0.115463896999407 no 2997 0.103357874261925 981 903329 SGTC_313 3474-0040 5.03 µM -1.26275385145302 0.115443578733215 no 2998 0.103338827126338 993 1043375 YIL048W NEO1 SGTC_299 1273-0059 1.44 µM -1.26463032525871 0.115084178121157 no 2999 0.103001938507901 942 2848077 SGTC_432 NS 1619 61.3 µM -1.26678423115268 0.114672622603268 no 3000 0.102616225999949 972 4552 A K+/calcium channel activator. SGTC_999 SEC7.066 22.7 µM -1.26851643174439 0.114342404652515 no 3001 0.102306793257318 995 740511 YDR170C SEC7 SGTC_1130 3454-2858 15.9 µM -1.27377855569264 0.113343414112925 no 3002 0.101370953540995 983 715628 YIL048W NEO1 SGTC_263 alizarin 107.927 µM -1.27423278146767 0.113257474189348 no 3003 0.101290465338035 1006 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2409 alverine citrate 63.97 µM -1.28102105777948 0.111978661492319 no 3004 0.100093134879848 969 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1621 st003705 32.4 µM -1.28150369453047 0.111888134440178 no 3005 0.100008401540836 979 24207032 SGTC_1887 st057648 70.8 µM -1.28182311543277 0.111828250192661 no 3006 0.0999523517395777 990 688672 SGTC_598 3937-0236 20.2 µM -1.28497400441903 0.111238757303884 no 3007 0.0994006841276852 990 1379313 SGTC_3335 9143315 29.6265 µM -1.28530389740242 0.111177167250436 no 3008 0.0993430543897963 974 4899691 SGTC_1913 st060213 96.1 µM -1.28649540572241 0.110954919502236 no 3009 0.0991351105945935 988 688959 SGTC_2572 astragaloside iv 100 µM -1.29265636718444 0.109810814183422 no 3010 0.0980649674935985 978 45006101 An anti-inflammatory agent. SGTC_2725 haloperidol 53.21 µM -1.29305242123279 0.109737556734372 no 3011 0.0979964646048052 978 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2366 9070441 60.58 µM -1.29382783309515 0.109594231705648 no 3012 0.0978624482121299 977 6837235 SGTC_1825 st052143 62.6 µM -1.29425317026464 0.109515670643749 no 3013 0.0977889931913824 991 674173 SGTC_2594 a-mangostin 100 µM -1.29591148373587 0.109209761352247 no 3014 0.0975029911892534 1008 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2702 st077768 96.8 µM -1.29733059939448 0.108948464825979 no 3015 0.0972587301119523 967 6484119 SGTC_293 4049-0273 38.5 µM -1.29775833604151 0.108869795470562 no 3016 0.0971851953427545 975 1380311 SGTC_980 1473-0395 201 µM -1.29852651393761 0.108728614685335 no 3017 0.0970532357252557 982 768876 SGTC_542 3381-0244 89.3 µM -1.30047059484486 0.108371907052125 no 3018 0.0967198640758505 1002 1112843 SGTC_1941 st076221 61.8 µM -1.30427388453971 0.107676501237395 no 3019 0.0960701081189947 949 2828568 SGTC_1660 st012960 28.1 µM -1.30852622369691 0.106902803075882 no 3020 0.0953474429879351 992 24207266 SGTC_163 TUB2.036 7.546 µM -1.30856753727919 0.106895305938762 no 3021 0.0953404416216598 963 15992207 YJR013W GPI14 SGTC_2769 toremifene 3.73 µM -1.31021610452181 0.106596451487433 no 3022 0.0950613695892304 994 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2616 abietic acid 100 µM -1.31154115534005 0.106356682075266 no 3023 0.0948374994340923 998 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_964 1287-0107 19.4 µM -1.31464432475047 0.105796684764936 no 3024 0.0943147330164881 991 51516812 YPR165W RHO1 SGTC_3334 9142812 21.919 µM -1.31726742825454 0.105324984870859 no 3025 0.0938744995545962 992 45283678 SGTC_1675 st018485 24.5 µM -1.31842141779354 0.1051179511794 no 3026 0.09368130747442 1003 3323024 SGTC_2453 5731132 22.18 µM -1.31891488774933 0.105029509219669 no 3027 0.0935987841805933 1007 1362040 SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.32062303173719 0.104723783702571 no 3028 0.093313544681165 985 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.32118885499522 0.104622654266993 no 3029 0.0932192007463753 994 6708760 SGTC_562 3772-2733 112 µM -1.32186741795588 0.104501468202884 no 3030 0.0931061518493402 991 2876874 YIL048W NEO1 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.32247450736372 0.104393132982731 no 3031 0.0930050963842036 1025 279621 SGTC_3311 9131146 2.8755 µM -1.32607182215975 0.103752861069858 no 3032 0.0924079542762324 1003 4900406 YPR165W RHO1 SGTC_1108 betulinic acid 729.144 nM -1.32641882102453 0.103691251089137 no 3033 0.0923505040091918 988 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1570 verbenone 133 µM -1.33325982265748 0.102482040144274 no 3034 0.0912232768081669 1002 29025 A natural terpanoid with antifungal properties. SGTC_2976 9009005 19.48 µM -1.33601258785536 0.101998367154056 no 3035 0.0907725794692994 977 2993148 SGTC_2142 5622915 118.518 µM -1.33772196150686 0.101698859887631 no 3036 0.0904935445858455 998 5322196 SGTC_333 3486-0131 40.1 µM -1.3381494911805 0.101624050637435 no 3037 0.090423855120265 978 6744690 SGTC_411 enrofloxacin 100 µM -1.33946892002154 0.101393429316239 no 3038 0.0902090329210639 994 71188 A bacterial gyrase inhibitor. SGTC_2191 5911152 200 µM -1.3402137255593 0.101263414152259 no 3039 0.0900879352690913 997 2875902 SGTC_2240 6690706 185.951 µM -1.34244127311394 0.100875292744753 no 3040 0.0897264799592302 996 805876 SGTC_1167 k781-0610 148 µM -1.34423992856008 0.100562692609819 no 3041 0.08943540690512 984 4525169 SGTC_3342 9147791 14.508 µM -1.34606925969844 0.100245486621523 no 3042 0.0891400906541027 984 1838168 SGTC_340 k038-0059 454 µM -1.34610384164302 0.100239497154674 no 3043 0.089134514949592 993 23733424 SGTC_2850 9015429 58.44 µM -1.34761670259594 0.0999777307585421 no 3044 0.088890847823607 1008 6457570 SGTC_266 formosanin C 406 nM -1.34770505361588 0.0999624590535422 no 3045 0.0888766330148858 966 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_622 1348-1566 26.3 µM -1.34822735153312 0.0998722132939845 no 3046 0.0887926349986601 994 7340407 SGTC_3308 9128332 17.569 µM -1.34907641032897 0.0997256348570126 no 3047 0.0886562121859006 994 17332805 YDL196W YDL196W SGTC_1630 st005209 31.3 µM -1.34922688232449 0.0996996743198569 no 3048 0.0886320513402205 978 3367314 SGTC_456 gingerol 170 µM -1.3538479722685 0.0989048124505445 no 3049 0.087892442561864 1010 442793 A herb. SGTC_110 0850-0284 111.64 µM -1.35734000730655 0.0983072392295961 no 3050 0.0873366004343912 964 3906265 SGTC_396 dithiazanine 1.25 µM -1.35758509522326 0.0982653981731554 no 3051 0.0872976875205941 990 10578 An antihelmenthic. SGTC_75 0159-0059 199.013 µM -1.35861017966755 0.0980905385962426 no 3052 0.0871350738643717 992 5377270 SGTC_1955 wogonin 32.4 µM -1.35982900960416 0.0978829265989788 no 3053 0.0869420200125029 985 5281703 A flavanone. SGTC_2796 7949634 45.45 µM -1.36208130806879 0.0975001243410267 no 3054 0.0865861132874101 990 2971588 SGTC_1136 pergolide 1.05886 µM -1.36496367749814 0.0970118379711598 no 3055 0.0861322332522154 998 47811 A dopamine receptor agonist. SGTC_930 2810-3379 265 µM -1.36536698071138 0.0969436599951433 no 3056 0.0860688682334947 1026 1015764 SGTC_3121 9125696 49.47 µM -1.36607605502591 0.0968238770429642 no 3057 0.0859575465355068 1035 1235365 SGTC_3188 9110789 49.47 µM -1.37135009833627 0.0959363488931681 no 3058 0.085132922708727 1011 849217 SGTC_2921 7974240 10.71 µM -1.37166586590233 0.0958834012627096 no 3059 0.0850837395732214 999 2979074 YDR527W RBA50 SGTC_1428 4049-0204 61.7 µM -1.37207883605653 0.0958141872264812 no 3060 0.0850194485557787 1005 X1428 SGTC_1994 st072947 40.9 µM -1.3741593108669 0.0954660573429243 no 3061 0.0846961148119534 1007 5286565 YDL195W SEC31 SGTC_1687 st020778 55.3625 µM -1.37458624172723 0.0953947334466687 no 3062 0.0846298782046869 1015 4259299 SGTC_2110 5483698 200 µM -1.37668280903537 0.0950450460954241 no 3063 0.0843051679931946 989 2848765 YHR062C RPP1 SGTC_1208 2323-2347 50.3 µM -1.37738159120549 0.0949287059660743 no 3064 0.0841971506598816 1007 5412760 SGTC_1494 4358-1428 177 µM -1.38629957094353 0.0934531555983441 no 3065 0.0828277239134506 994 1564571 SGTC_107 0358-0022 2.6945 µM -1.39228441521154 0.0924724590122806 no 3066 0.0819181444803938 1026 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_3028 9087778 49.47 µM -1.39882417171985 0.0914095617992139 no 3067 0.0809328579674248 995 17217395 SGTC_3197 9113331 49.47 µM -1.40000805157713 0.091218119478661 no 3068 0.0807554536983276 993 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_495 decylubiquinone 155 µM -1.4012177759985 0.0910228051681785 no 3069 0.0805744801063356 1006 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1569 carminic acid 40.6 µM -1.4016160051009 0.0909585775769011 no 3070 0.0805149724908065 1007 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2678 equilin 100 µM -1.40210254120124 0.0908801532037529 no 3071 0.0804423141734675 970 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_90 0870-0863 4.608 µM -1.40308920255718 0.0907212680775341 no 3072 0.0802951202694859 1014 1738164 SGTC_1135 dihydrocapsaicin 536.708 nM -1.41136483358499 0.0893967257435711 no 3073 0.0790685332895258 1016 107982 A Capsaicinoid. SGTC_1376 2910-0861 41.3 µM -1.41310343223587 0.0891202949703307 no 3074 0.0788126571074736 1020 1112859 SGTC_922 1866-0035 480 µM -1.41471135819579 0.088865207346024 no 3075 0.0785765713974497 987 3156169 SGTC_3312 9133330 71.43 µM -1.41476634304056 0.088856493959101 no 3076 0.0785685076688354 1026 17617324 SGTC_642 0335-0876 158 µM -1.4181453342852 0.088322248901253 no 3077 0.0780741689886459 1017 6812350 SGTC_509 pifithrin 175 µM -1.42090207308988 0.0878881629410872 no 3078 0.0776726151239156 1028 4817 A p53 inhibitor. SGTC_1243 0416-0003 5.65 µM -1.42185326136054 0.0877387552458178 no 3079 0.0775344269572423 1007 2141977 SGTC_2462 5162487 171.77 µM -1.42481609274109 0.0872745834491724 no 3080 0.0771051846070944 1026 2259986 SGTC_573 3702-0553 84.7 µM -1.42733424751542 0.0868815202411174 no 3081 0.0767417867626312 1003 1222756 SGTC_2842 9000675 19.48 µM -1.42829192517585 0.0867323822978283 no 3082 0.0766039255254355 989 2989072 SGTC_2102 5377816 72.7585 µM -1.43098121980476 0.0863146048247294 no 3083 0.0762177987940883 1002 1379702 SGTC_3025 9087895 49.47 µM -1.43278111793359 0.0860358354835782 no 3084 0.0759601995358095 1014 17173641 SGTC_3156 9099931 49.47 µM -1.43322829589034 0.0859666808701644 no 3085 0.0758963028905939 1015 18111053 SGTC_2680 butyl paraben 22.24 µM -1.43508952022418 0.0856792953971597 no 3086 0.0756307947433271 1045 7184 An antifungal and steroid mimetic. SGTC_1647 st011722 22.4 µM -1.43541422600479 0.0856292324275188 no 3087 0.075584547262971 1000 2854783 SGTC_533 1222-0222 6.71 µM -1.43913837224106 0.0850566107519914 no 3088 0.0750556609978868 1026 3982874 SGTC_1596 piperlongumine 63 µM -1.43918184662738 0.0850499431545451 no 3089 0.0750495036724489 989 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_813 k007-0158 173 µM -1.43969776174855 0.0849708479793537 no 3090 0.074976463451463 1012 6523916 SGTC_821 1114-0266 29.2 µM -1.44415039648728 0.0842905026592199 no 3091 0.0743483372466482 1008 3123235 SGTC_3166 9102297 49.47 µM -1.44584326432407 0.0840329144166345 no 3092 0.0741105840869476 1010 25237072 SGTC_3238 9133470 49.47 µM -1.44799915746424 0.0837057280232984 no 3093 0.0738086431122706 995 3534688 SGTC_1265 0819-1001 68.8 µM -1.44861704091167 0.0836121324007648 no 3094 0.0737222797833041 1018 3106768 SGTC_379 3970-0972 5.9 µM -1.45010324249392 0.0833873279262511 no 3095 0.0735148655277015 1026 2898042 YBL034C STU1 SGTC_2965 9082772 38.63 µM -1.45352572101328 0.0828713682648598 no 3096 0.0730389217926476 873 16459634 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.45416718406697 0.082774931610673 no 3097 0.0729499803397302 1005 23665772 A membrane-active detergent. SGTC_1657 st012939 43.4 µM -1.454638721962 0.0827040951354354 no 3098 0.0728846525855102 1008 24207257 SGTC_3292 9120825 59.784 µM -1.45959435865919 0.0819623947461207 no 3099 0.0722007953030369 1002 24824900 SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.46099209293333 0.0817541075349395 no 3100 0.0720088056970005 1026 140250 A respiratory chain inhibitor. SGTC_2683 piperine 63.03 µM -1.46401194325053 0.081305458849446 no 3101 0.0715953425572567 1028 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_601 0986-0029 62.9 µM -1.46664196092512 0.080916241600984 no 3102 0.071236739493537 991 24747981 SGTC_3107 9121808 49.47 µM -1.46750396781992 0.080788979424369 no 3103 0.0711195053419708 959 662681 SGTC_15 0266-0086 27.098 µM -1.4682694064454 0.0806761008123423 no 3104 0.0710155288465526 1038 1712902 YIL048W NEO1 SGTC_1959 st077091 55.8 µM -1.47412878937324 0.0798159647741276 no 3105 0.0702234592088937 1009 821356 YKL052C ASK1 SGTC_1395 3486-0190 4.35 µM -1.48233427261262 0.0786231115212468 no 3106 0.0691256866497631 1025 6748079 SGTC_2699 st077704 54.6 µM -1.4861146535039 0.0780781149655655 no 3107 0.0686243984908892 1023 645852 SGTC_1753 st043925 64 µM -1.48758931836679 0.0778662994537077 no 3108 0.068429616060548 1028 670181 SGTC_1525 8-methoxypsoralen 92.5 µM -1.48787525077706 0.077825279682119 no 3109 0.0683918978411521 1042 4114 Related to psoralen; DNA damaging agent. SGTC_40 0327-0103 19.753 µM -1.48805567249853 0.0777994048805278 no 3110 0.0683681061152616 985 409036 SGTC_1876 myriocin 605 nM -1.48956245938122 0.077583567118232 no 3111 0.0681696594976915 1014 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2162 5663267 200 µM -1.49713619547311 0.0765055576939315 no 3112 0.0671789116458891 1016 6456493 SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.50057639682746 0.076019675469684 no 3113 0.0667325800049925 1001 6708630 An antioxidant. SGTC_2508 celastrol 40.54 µM -1.50693783300817 0.0751274019374376 no 3114 0.0659132963978275 980 122724 Celastrol is a natural product and antioxidant. SGTC_3310 9130229 44.1445 µM -1.50694493412108 0.0751264103963888 no 3115 0.0659123862271864 1025 7761258 SGTC_2826 7992541 19.48 µM -1.50970472515958 0.0747418109103987 no 3116 0.0655593925233087 1040 2985066 SGTC_2077 5212015 200 µM -1.51056353558436 0.0746224356600567 no 3117 0.065449845141637 1010 780900 SGTC_1975 st070967 30.8 µM -1.51321071503748 0.0742553913437326 no 3118 0.0651130716754294 1016 261391 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.5139416235679 0.0741542906147087 no 3119 0.0650203230011471 1029 688662 SGTC_680 0417-1641 114 µM -1.52135450195268 0.0731348591737473 no 3120 0.0640854499757154 1025 2835990 SGTC_398 bronopol 33.3 µM -1.52325195389448 0.0728756501705289 no 3121 0.0638478412556597 1018 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2851 9015922 71.43 µM -1.52356872425946 0.0728324450806994 no 3122 0.0638082404662602 1021 2996893 SGTC_102 gallobenzophenone 83.616 µM -1.52454781062743 0.0726990290555019 no 3123 0.063685961556924 1003 70837 SGTC_1203 3992-3522 103 µM -1.52766611581111 0.0722753576703755 no 3124 0.063297728548514 1036 5322312 SGTC_2875 9039966 71.43 µM -1.52942984703683 0.0720365659018714 no 3125 0.0630789589678473 1028 6463691 SGTC_578 3460-0051 92 µM -1.52993986934347 0.0719676267904511 no 3126 0.0630158067441016 1038 2876744 SGTC_1732 st034308 51.822 µM -1.53336335934436 0.071506186424522 no 3127 0.0625931756975513 1001 830119 SGTC_2781 5567276 71.43 µM -1.53728020520538 0.0709810368729663 no 3128 0.0621123533661813 1015 2853274 SGTC_2174 5790901 200 µM -1.53788199410278 0.0709006154673772 no 3129 0.0620387353056403 1019 786020 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.53791104669882 0.0708967347305814 no 3130 0.06203518296594 1027 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_610 4215-0184 155 µM -1.54177906588903 0.0703815148545579 no 3131 0.0615636454148377 980 5605015 SGTC_2028 5153890 36.43 µM -1.54260571510369 0.0702717795333412 no 3132 0.0614632352685937 1035 2830968 YPR165W RHO1 SGTC_560 2332-1943 155 µM -1.54681873377093 0.0697145563639022 no 3133 0.0609534807587406 1018 21177716 SGTC_207 4185-0010 4.486 µM -1.54797028780062 0.0695628427410473 no 3134 0.0608147251330761 1018 3761753 SGTC_3136 9095672 49.47 µM -1.5514223813924 0.0691095634356865 no 3135 0.0604002475206157 1008 17217380 SGTC_683 panaxydol 45 µM -1.55607013848363 0.0685028861089956 no 3136 0.0598457074571412 1029 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_3039 9090270 49.47 µM -1.55668046300275 0.0684235258279385 no 3137 0.0597731847101138 1007 17173750 SGTC_692 k241-0027 77.8 µM -1.57321688187497 0.066300189999334 no 3138 0.0578343037999413 1023 3600480 SGTC_1434 4073-0095 163 µM -1.58830017496322 0.0644082720597021 no 3139 0.0561092389827578 1028 24133745 SGTC_3040 9091894 49.47 µM -1.58989814567583 0.0642103191032447 no 3140 0.0559288828598277 1023 25236966 SGTC_1518 st038567 90.8 µM -1.59341569609681 0.0637762394120126 no 3141 0.0555334834161983 1041 77966 SGTC_2626 ethyl orsellinate 100 µM -1.59415450150138 0.0636853586259509 no 3142 0.0554507171475524 1031 75653 A natural product. SGTC_389 tpck 16.7 µM -1.59589124160169 0.0634721182626844 no 3143 0.0552565386532266 1047 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2618 avocadyne 43.43 µM -1.60119438953228 0.0628244254532807 no 3144 0.0546669355553047 1042 3015189 SGTC_9 0092-0002 10.449 µM -1.60840128087813 0.0619524904041829 no 3145 0.0538736606640595 1040 759368 SGTC_2833 9001315 45.46 µM -1.61567178056167 0.0610824580668739 no 3146 0.0530826476659917 1029 2989378 SGTC_2145 5634607 200 µM -1.61794767882656 0.0608120817449248 no 3147 0.0528369369090668 1045 308662 SGTC_515 4092-1064 102 µM -1.62022455765149 0.0605425263110908 no 3148 0.0525920239849595 1052 717353 SGTC_2442 5158906 48.48 µM -1.62148547788663 0.060393651007906 no 3149 0.0524567809851458 1034 1893835 SGTC_603 3794-0023 45.9 µM -1.62756867007498 0.0596794373668781 no 3150 0.0518081884042382 1049 3802260 SGTC_638 3970-0837 4.09 µM -1.62761091887444 0.0596745002755228 no 3151 0.0518037062081006 1031 4118451 YLR208W SEC13 SGTC_710 3448-4187 58 µM -1.63107799937999 0.0592704353671436 no 3152 0.051436931135748 1030 3946412 SGTC_2654 protoveratrine a 100 µM -1.63340752261953 0.0590001522799798 no 3153 0.0511916579740706 1048 5702278 A heart drug and vasodilator. SGTC_1009 4106-0057 9.87 µM -1.63363526399221 0.058973780542595 no 3154 0.051167729334403 1026 2928005 SGTC_218 alverine citrate 93.75 µM -1.64105121639935 0.058120079532574 no 3155 0.0503933920357047 1031 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2772 vinpocetine 57.06 µM -1.64116196036828 0.0581074050176707 no 3156 0.0503818998534383 1038 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_3112 9123419 49.47 µM -1.64763136149104 0.0573707518918207 no 3157 0.0497141704076406 1053 17015854 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.64767908877347 0.0573653447484453 no 3158 0.0497092706742699 1040 688751 SGTC_1692 fluoroquinolonic acid 71 µM -1.65059897375076 0.0570353056539892 no 3159 0.0494102442907729 1043 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_503 tyrphostin 8 294 µM -1.6616249231258 0.0558024886743042 no 3160 0.0482940014604109 1058 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_149 3970-0822 46.1 µM -1.66331826237494 0.0556150321089656 no 3161 0.048124372490036 1026 3114250 YBL034C STU1 SGTC_1717 st033143 58.0435 µM -1.66403930771943 0.0555353617604868 no 3162 0.0480522872014551 1036 674616 SGTC_2259 7964009 200 µM -1.67443398739167 0.0543968078205363 no 3163 0.047022668931882 1034 313134 SGTC_1960 st011366 51.8 µM -1.67599102830472 0.0542278628939299 no 3164 0.0468699749768267 1029 3972846 SGTC_275 trichlorophene 5.69 µM -1.68068462144937 0.0537211012385105 no 3165 0.0464120946273517 1026 62616 SGTC_508 roscovitine 141 µM -1.68521066103839 0.0532359895401587 no 3166 0.0459739674522512 1059 160355 A CDKinase inhibitor. SGTC_2093 5331342 194.4 µM -1.6853230056946 0.0532239924869286 no 3167 0.0459631347369307 1045 33839 SGTC_2907 7721985 69.9 µM -1.68635637961609 0.0531137411235702 no 3168 0.0458635889016698 1045 3267881 SGTC_1788 fluconazole 20 µM -1.68639297728102 0.0531098398165362 no 3169 0.0458600665948285 1036 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2563 tomatine 8.54 µM -1.68780179527307 0.0529598326178534 no 3170 0.0457246414362682 1043 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1321 1326-2144 215 µM -1.69171014626799 0.0525454405734223 no 3171 0.045350626455991 1047 3513030 SGTC_2328 6201408 200 µM -1.69246693026691 0.0524654989832605 no 3172 0.0452784901422835 1036 2890418 SGTC_375 3970-0961 9.27 µM -1.69293701155656 0.0524158913764669 no 3173 0.04523372869849 1020 2898222 SGTC_1607 st000305 50.6 µM -1.70048699814871 0.0516242334378531 no 3174 0.0445196799881036 1045 5457690 SGTC_3045 9092950 49.47 µM -1.70884138338372 0.0507593406403704 no 3175 0.0437401673779857 1040 44120432 SGTC_1940 st075990 51.1 µM -1.70950312738704 0.0506913293443921 no 3176 0.0436788964555566 1050 1084979 SGTC_1304 1165-0502 251 µM -1.71107106650743 0.0505304727714571 no 3177 0.0435339972943011 1046 767425 SGTC_1669 st015249 58.4 µM -1.71190856143973 0.0504447200157528 no 3178 0.0434567603385285 1073 722793 SGTC_1262 0737-0114 49.6 µM -1.72027335875238 0.0495945804803559 no 3179 0.0426913818802478 1046 765919 SGTC_33 0986-0033 35.816 µM -1.74207367042934 0.047432613234808 no 3180 0.0407477770522416 1028 2848082 SGTC_1205 4161-2785 76 µM -1.74265534895527 0.0473759785326296 no 3181 0.0406969177832284 1039 3498106 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.74293800583189 0.0473484774232537 no 3182 0.0406722221840682 1034 5024745 SGTC_3221 9128209 49.47 µM -1.74455071201906 0.0471918137563679 no 3183 0.0405315533544334 1048 16460723 SGTC_635 k038-0028 24.7 µM -1.74510709797605 0.047137861068851 no 3184 0.0404831141371545 1057 4035102 SGTC_2927 9011802 47.9 µM -1.74914445921011 0.046747838365369 no 3185 0.0401330259047392 1043 43912568 SGTC_3034 9090421 49.47 µM -1.75310627717624 0.0463676343123551 no 3186 0.0397918831340824 1044 17173761 SGTC_3338 9144300 39.5675 µM -1.76259040264845 0.0454675515605175 no 3187 0.0389847984628104 1030 4901274 SGTC_2334 9017922 200 µM -1.7626479415826 0.0454621340689349 no 3188 0.038979942972301 1039 3163164 SGTC_1492 4158-0558 28.5 µM -1.76830727557155 0.0449318193730888 no 3189 0.0385047741324977 1036 3967268 SGTC_2675 theaflavin digallate 100 µM -1.77226089290074 0.0445643040989219 no 3190 0.0381756298492571 1059 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1980 st071811 45.7 µM -1.79737067908215 0.042286361110948 no 3191 0.0361383961789951 1058 4974850 SGTC_2182 6325192 200 µM -1.79962936836984 0.0420861582788046 no 3192 0.0359595903009882 1032 736248 SGTC_2398 5228213 48.84 µM -1.81332537356466 0.0408885625690903 no 3193 0.0348908260136842 1051 80771 YMR134W ERG29 SGTC_2216 7189485 200 µM -1.81525019192332 0.0407224917531369 no 3194 0.0347427347656748 1054 731273 SGTC_1520 flindersine 88 µM -1.81733276686956 0.0405434268248149 no 3195 0.0345830878060203 1025 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_339 3091-4833 71.4 µM -1.82240089832539 0.040110325999586 no 3196 0.0341970891929306 1025 3240077 SGTC_2429 5902844 64.44 µM -1.82805142960945 0.0396318952948127 no 3197 0.0337709167133703 1050 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_847 0342-0274 5.54 µM -1.83140039742175 0.0393505352390554 no 3198 0.0335204010201069 1052 18097 SGTC_1813 st051246 8.6015 µM -1.83225177722861 0.0392792671517584 no 3199 0.0334569589970335 1059 5291959 SGTC_2553 4-methylesculetin 85.09 µM -1.83770410658594 0.0388253451472788 no 3200 0.0330530092116634 1051 5319502 SGTC_2060 5238662 140 µM -1.84320875514762 0.038371410905934 no 3201 0.032649268547618 1057 790130 SGTC_3074 9116018 49.47 µM -1.84322416169755 0.0383701465212921 no 3202 0.0326481442812003 1066 17027303 SGTC_697 0508-1955 564 µM -1.84937710510351 0.0378678956566492 no 3203 0.0322016895090401 1047 6243113 SGTC_1026 k007-1105 30.6 µM -1.86926744356689 0.0362808824283773 no 3204 0.0307928075985466 1053 7066794 SGTC_772 k072-0172 35.3 µM -1.88142304672385 0.0353381045587384 no 3205 0.0299571971150198 1036 5861980 SGTC_556 4058-0063 51.5 µM -1.88449363871335 0.03510315790233 no 3206 0.0297491172319773 1066 6615692 SGTC_2597 laccaic acid a 100 µM -1.88814787853492 0.0348252252977298 no 3207 0.0295030503799169 1064 5491415 A textile dye. SGTC_933 2914-0560 114 µM -1.88974897256356 0.0347040204792407 no 3208 0.029395770501422 1050 463887 SGTC_1790 st045711 43.5 µM -1.89062968439922 0.0346374973143991 no 3209 0.0293368974069685 1043 585119 SGTC_808 0711-0032 135 µM -1.90784822718279 0.0333578261206049 no 3210 0.0282054177143248 1061 4252555 SGTC_1931 st074438 57.1 µM -1.90808463861911 0.0333405308479391 no 3211 0.0281901389000677 1067 2787313 SGTC_631 k072-0230 41.5 µM -1.91043111271083 0.0331692686979306 no 3212 0.0280388640547944 1059 5773147 SGTC_2068 5226020 147 µM -1.9105184739571 0.0331629064800874 no 3213 0.0280332450403801 1062 1810509 SGTC_292 k038-0015 474 µM -1.92118874759352 0.0323933536969299 no 3214 0.0273539581238604 1064 46368540 SGTC_2724 maprotiline 69.64 µM -1.92417278969729 0.0321807970173778 no 3215 0.0271664643067727 1033 4011 A tricyclic antidepressant. SGTC_1217 1183-1422 255 µM -1.93312786048533 0.031549819262888 no 3216 0.0266102243737561 1054 2849664 SGTC_1853 st056710 91.2 µM -1.93480651479952 0.031432686219903 no 3217 0.0265070216758661 1064 269167 SGTC_734 2023-0417 80 µM -1.94274317196769 0.0308837409159595 no 3218 0.0260235985945444 1067 3935732 SGTC_433 pimozide 108 µM -1.94362017580909 0.0308235720773479 no 3219 0.0259706354958817 1064 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_3046 9092212 49.47 µM -1.94987481536926 0.0303972665143693 no 3220 0.0255955207735385 1072 25236637 SGTC_1040 k898-0338 155 µM -1.95393298233788 0.030123290601835 no 3221 0.0253545716887192 1060 20969351 SGTC_174 3553-0389 74.3 µM -1.95493375580787 0.0300560417417233 no 3222 0.025295444838635 1067 738071 SGTC_1043 0916-0009 19.3 µM -1.95880628802575 0.0297969913804275 no 3223 0.0250677384601616 1066 3101130 SGTC_428 3448-4153 16.5 µM -1.95929686715805 0.029764307011406 no 3224 0.0250390152202163 1058 3834874 SGTC_2838 9002687 71.43 µM -1.96686487616178 0.0292638532536475 no 3225 0.024599395393584 1061 6457060 SGTC_568 1193-0097 7.48 µM -1.96823933287216 0.0291737179384094 no 3226 0.0245202533021121 995 3646150 SGTC_1794 st048918 76.9 µM -1.97343724778942 0.0288349273766676 no 3227 0.0242228837117645 1026 672303 SGTC_2690 usnic acid 100 µM -1.97774097695957 0.0285568991649848 no 3228 0.0239789675147595 1062 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2586 curcumin 80 µM -1.97824597250086 0.0285244222631837 no 3229 0.0239504823902263 1078 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1879 gemcitabine 100 µM -1.97902409932533 0.0284744400935836 no 3230 0.0239066465057599 1075 60750 A nucleoside analog which inhibits DNA replication. SGTC_253 dyclonine 31.25 µM -1.98132430730938 0.0283271145103181 no 3231 0.0237774580806111 1071 3180 An oral anasthetic. SGTC_37 0566-0070 1.56 µM -1.98168511640269 0.0283040627759805 no 3232 0.0237572470199473 1064 1626686 SGTC_699 0375-0592 111 µM -1.98343019481965 0.0281927917030273 no 3233 0.0236596985695776 1060 762578 SGTC_1331 1472-0049 76.2 µM -2.00195161528087 0.0270341010080998 no 3234 0.0226449677932148 1057 24051409 SGTC_1053 3366-3204 134 µM -2.00911705486456 0.0265966263284949 no 3235 0.0222623606842662 1068 3632071 YPR165W RHO1 SGTC_145 3737-0113 38.366 µM -2.01762814008306 0.0260846953404162 no 3236 0.0218150019494033 1059 6849351 SGTC_769 0302-0231 76 µM -2.01899301559456 0.0260033715547567 no 3237 0.0217439727242551 1070 571869 YER009W NTF2 SGTC_566 0958-0068 16.5 µM -2.02855501349563 0.0254395639123913 no 3238 0.0212518172856002 1048 6815365 SGTC_857 0438-0306 1.35 µM -2.03659942372266 0.0249732022613955 no 3239 0.020845100297467 1070 4686136 SGTC_1951 sophoraflavanone G 9.2 µM -2.04029356936122 0.0247614539549738 no 3240 0.020660547463219 1051 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1150 3909-7983 10.9 µM -2.0463892350904 0.0244153442245302 no 3241 0.0203590451763457 1068 23965914 SGTC_1229 0139-0193 12.2 µM -2.04877954538683 0.0242807362735124 no 3242 0.0202418383902967 1060 3090752 SGTC_127 0180-0333 59.125 µM -2.05024819261765 0.0241983403593904 no 3243 0.0201701086672014 1014 771601 SGTC_43 0570-0105 72.5 µM -2.0523729152449 0.0240795522085879 no 3244 0.0200667173360719 1059 1114046 YDL195W SEC31 SGTC_1287 0971-0001 34.6 µM -2.05441961312779 0.0239655898662189 no 3245 0.0199675481934238 1063 4665869 SGTC_1336 1486-0901 104 µM -2.05442594881098 0.0239652377934899 no 3246 0.0199672418557764 1062 5006114 SGTC_2809 7964133 12.99 µM -2.05508580834637 0.0239285933152719 no 3247 0.0199353587059323 1077 1253665 SGTC_230 MPP+ 141.667 µM -2.0585171305626 0.0237387974021488 no 3248 0.0197702592821391 1073 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_3313 9133968 57.047 µM -2.06211140768685 0.0235413469613603 no 3249 0.0195985652617232 1050 1494643 SGTC_1705 st027868 56.3335 µM -2.07378274023845 0.0229096877346682 no 3250 0.0190497464150651 1050 292948 SGTC_1555 citronellol 128 µM -2.09997451941801 0.0215439967338999 no 3251 0.0178655413204254 1076 8842 A terpine precursor. SGTC_1793 st048256 72.231 µM -2.10385106504107 0.0213478322298523 no 3252 0.0176957203704353 1061 672022 SGTC_31 0508-1974 57.237 µM -2.10790806337492 0.0211441557892034 no 3253 0.0175194713109575 1064 6810525 SGTC_552 k242-0005 476 µM -2.11066968201279 0.0210064546175977 no 3254 0.0174003568320395 1080 4088318 SGTC_77 0828-0286 12.516 µM -2.12101114109035 0.0204975265615521 no 3255 0.0169604324364293 1063 745345 SGTC_528 3492-0019 172 µM -2.1276781271964 0.0201749977531599 no 3256 0.0166818898144227 1061 2869262 SGTC_570 0987-0065 62.6 µM -2.13474493890072 0.0198378352150719 no 3257 0.0163909250329855 1055 3104428 SGTC_427 1354-0053 47.3 µM -2.1397932015878 0.0195999177486873 no 3258 0.0161857414393878 1072 6813657 SGTC_1458 k015-0034 6.33 µM -2.14241194325256 0.0194774575722585 no 3259 0.0160801738316898 1077 3598957 SGTC_974 1326-0144 138 µM -2.14579778628294 0.0193200893638026 no 3260 0.0159445576703027 1073 5411856 SGTC_1795 st049545 62.3 µM -2.15934103909338 0.0187013825766357 no 3261 0.0154118592479827 1067 5291882 SGTC_1688 st021091 57.6 µM -2.16025606658222 0.018660195815563 no 3262 0.0153764259922195 1082 3656366 SGTC_846 0335-0850 148 µM -2.16075738885621 0.0186376633037963 no 3263 0.0153570426121649 1066 6819598 SGTC_2676 harmalol 100 µM -2.16663145468781 0.018375367623829 no 3264 0.0151314834908561 1068 5459187 A monoamine oxidase inhibitor SGTC_832 4083-0019 164 µM -2.17815102350664 0.0178701038584019 no 3265 0.0146973974835672 1078 1990758 SGTC_96 0929-0093 37.281 µM -2.17975740808967 0.0178005959320257 no 3266 0.0146377243160094 1069 6991579 SGTC_3102 9121669 49.47 µM -2.18012398433225 0.0177847666152373 no 3267 0.0146241361767781 1086 41905072 SGTC_1179 1021-1431 9.29 µM -2.19560430677204 0.0171271774455889 no 3268 0.0140601388603251 1080 2840958 SGTC_744 1594-0068 283 µM -2.19707521131867 0.0170657898902247 no 3269 0.0140075375794172 1071 668392 SGTC_1129 3453-1384 223 µM -2.21519712920667 0.0163247805426431 no 3270 0.0133732684259247 1076 1084452 SGTC_2344 7990960 76.95 µM -2.22265465664997 0.0160279409678513 no 3271 0.0131195478171669 1049 140813 SGTC_319 1348-1596 45.5 µM -2.23465844792541 0.0155598591915056 no 3272 0.0127198902543652 1075 5380505 SGTC_2470 5664817 21.68 µM -2.2430214300067 0.0152407257520361 no 3273 0.0124477163070579 1086 2859561 SGTC_2483 5729050 27.16 µM -2.26036877465866 0.0145966359196493 no 3274 0.0118991863960749 1068 2865180 SGTC_1476 4112-3294 3.34 µM -2.27668978528941 0.0140121782972826 no 3275 0.0114023784673979 1036 704369 SGTC_1472 k841-0093 193 µM -2.27827937140692 0.0139563481325985 no 3276 0.0113549689563697 1085 X1472 SGTC_2233 sulbentine 40.3845 µM -2.28175008591269 0.0138351142571835 no 3277 0.0112520495979329 1042 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_3012 9080433 71.4286 µM -2.29094109291843 0.0135184455449089 no 3278 0.0109834104411271 1073 17688859 SGTC_3024 9090631 49.47 µM -2.30313144499226 0.0131081029827794 no 3279 0.0106357242793316 1080 25236383 SGTC_1559 coumarin 343 70.1 µM -2.30446945749234 0.0130637263034619 no 3280 0.0105981524664617 1075 108770 A hepatotoxic, DNA x-linker. SGTC_2749 bexarotene 57.39 µM -2.30497362935869 0.0130470385969214 no 3281 0.0105840251815062 1066 82146 An retinoic acid receptor inhibitor. SGTC_21 0849-0113 22.993 µM -2.31987202909679 0.0125621623396713 no 3282 0.0101739005523176 1085 1560156 SGTC_1750 st081859 2.357 µM -2.32648100738572 0.0123521141188884 no 3283 0.00999645226059212 1060 5291695 SGTC_1085 doxorubicin 7.67 µM -2.32860948144008 0.0122851172816489 no 3284 0.00993988165786529 1070 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1475 4092-1048 11.7 µM -2.33030028645956 0.01223212132968 no 3285 0.00989514281897864 1084 2881759 SGTC_3298 9116858 71.43 µM -2.34561477939608 0.0117610657830914 no 3286 0.00949786441436107 1088 2506942 SGTC_365 0121-0052 13.6 µM -2.36825019337655 0.0110936792433944 no 3287 0.00893622261254808 1055 3101739 SGTC_3143 9086658 49.47 µM -2.38433738318464 0.0106396136016393 no 3288 0.00855495403341847 1061 25236626 SGTC_2929 9013348 24.6 µM -2.38793817956126 0.0105402260184646 no 3289 0.00847159578526532 1072 2995952 SGTC_1045 1348-1485 165 µM -2.39773927115217 0.010273787337601 no 3290 0.00824830143801643 1081 6810614 SGTC_213 1246-0773 967 nM -2.40403518897135 0.0101057503826401 no 3291 0.0081076061706986 1078 6251622 SGTC_1549 4'-methoxyflavonol 74.6 µM -2.43427766013081 0.00933158635937268 no 3292 0.00746077196696661 1088 97141 SGTC_2787 5284540 71.43 µM -2.43606280668795 0.0092875561783144 no 3293 0.00742405309357393 1079 736958 SGTC_976 1348-1067 47.6 µM -2.4394037277004 0.0092056414964836 no 3294 0.00735576101194972 1084 5310671 YGL099W LSG1 SGTC_845 0330-0138 4.51 µM -2.44153457027304 0.00915372713404695 no 3295 0.00731249400738199 1081 9039800 SGTC_2858 9025781 8.96 µM -2.45475256308014 0.00883738304682492 no 3296 0.00704907956259626 1059 4894980 YPL153C RAD53 SGTC_1882 5615643 20 µM -2.49640619183184 0.00790230565300278 no 3297 0.00627294237066098 1080 2253075 SGTC_1603 st002045 67.8 µM -2.51755950245352 0.00746163959928037 no 3298 0.00590855037417651 1086 5887985 SGTC_2260 7964312 200 µM -2.53404093340111 0.00713345124122501 no 3299 0.00563777797513639 1087 231951 SGTC_109 0132-0036 33.701 µM -2.53882403905523 0.00704062245519802 no 3300 0.00556128743302726 1073 67274 A color developer. SGTC_1373 2887-0003 58.5 µM -2.54267500388402 0.00696666069543112 no 3301 0.00550037484988564 1084 776948 SGTC_2830 7992007 71.43 µM -2.57216161538195 0.00642271199397305 no 3302 0.00505328501368337 1076 1952075 SGTC_2934 9036370 36.88 µM -2.5751000416542 0.00637062155886441 no 3303 0.00501055484895794 1077 6462800 SGTC_224 benfluorex 43.875 µM -2.58628280260865 0.00617578421568743 no 3304 0.00485086467566099 1090 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_727 3032-0951 202 µM -2.58659011678942 0.0061705052213684 no 3305 0.00484654100244011 1089 3652836 SGTC_2681 menadione 3.18 µM -2.58670052237108 0.0061686096679686 no 3306 0.00484498852010545 1085 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_378 3970-0959 8.33 µM -2.60968360228276 0.00578506786722458 no 3307 0.00453129997528234 1090 6615653 SGTC_2723 salbutamol 83.58 µM -2.61625585156574 0.00567935335945126 no 3308 0.00444499580088415 1085 9884233 β2-adrenoceptor agonist SGTC_1199 1638-0010 4.46 µM -2.66278895310264 0.00497867537219609 no 3309 0.00387480009192236 1085 3111136 SGTC_457 grayanotoxin iii 135 µM -2.67945589256078 0.00474710401164985 no 3310 0.00368709588863398 1062 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_724 3910-0327 137 µM -2.68378147215837 0.00468859626354195 no 3311 0.00363973350421401 1087 2885483 SGTC_1175 0741-0056 27.6 µM -2.70900205703112 0.00436009721696983 no 3312 0.00337429606716365 1089 765927 SGTC_2520 obtusaquinone 4.71 µM -2.7245354439244 0.00416815967804176 no 3313 0.00321960092226397 1081 5967872 SGTC_591 4299-0174 154 µM -2.72803514680436 0.00412597333666385 no 3314 0.00318564095674398 1091 5509088 SGTC_2568 diosmetin 100 µM -2.73004115806083 0.00410196498134707 no 3315 0.00316632094360096 1082 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2674 ligustilide 100 µM -2.75096151374151 0.00385893706387746 no 3316 0.00297103120064414 1092 5319022 A signalling regulator. SGTC_1658 st012944 20 µM -2.77521941678167 0.00359335322523097 no 3317 0.00275822382619639 1084 24207260 SGTC_1976 st070609 63.5 µM -2.78059439791051 0.00353677433243733 no 3318 0.00271297410533441 1088 682556 SGTC_1710 st031758 61.5 µM -2.79523167158024 0.0033867305235337 no 3319 0.00259312674637864 1090 5394341 SGTC_3147 9097027 49.47 µM -2.8300304220875 0.00305273074798105 no 3320 0.00232717891262719 1087 25236841 SGTC_1864 st057645 30.4 µM -2.83450841085664 0.00301197819037237 no 3321 0.00229481248831008 1092 688666 SGTC_989 1501-0895 10.3 µM -2.83854439077228 0.00297566884203738 no 3322 0.00226599075755221 1089 2830112 SGTC_2251 lansoprazole 556 µM -2.84889665889553 0.002884332209542 no 3323 0.00219355639433402 1088 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1910 st062352 60.4 µM -2.85071376408604 0.00286856349587333 no 3324 0.0021810609073986 1089 2245730 SGTC_2067 5224629 34.075 µM -2.85896274083373 0.00279795256076365 no 3325 0.00212514351555145 1090 2835000 SGTC_1706 st031321 9.9705 µM -2.92870858438781 0.00226080953010882 no 3326 0.00170186686364717 1092 6103185 SGTC_41 0478-0632 82.643 µM -2.96046993666965 0.00204869974271387 no 3327 0.00153585049653823 1079 3750424 SGTC_762 1165-0429 115 µM -2.96585660097266 0.00201457269472833 no 3328 0.00150920595793896 1087 5967793 SGTC_182 3448-4371 550.524 µM -3.00396690275684 0.00178749679684209 no 3329 0.00133242156335513 1089 3491403 SGTC_2651 TUB2.036 5 µM -3.00504541817253 0.00178142357075731 no 3330 0.00132770597363685 1076 15992207 YFL037W TUB2 SGTC_1380 2291-0730 164 µM -3.01088480948954 0.00174886613435707 no 3331 0.0013024382538902 1086 2999191 SGTC_907 3448-6986 75.5 µM -3.01327323022865 0.00173570627278494 no 3332 0.00129223056731247 1087 590582 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -3.04292359379866 0.00157967529310573 no 3333 0.00117145906405351 1093 165521 SGTC_1685 st024049 53.0905 µM -3.04425911659643 0.00157295799154716 no 3334 0.00116627071256118 1091 1941139 SGTC_861 0443-0273 110 µM -3.04577062176624 0.00156538696680883 no 3335 0.0011604240808941 1092 6149169 SGTC_881 0833-0569 170 µM -3.09468708613889 0.00133759854829602 no 3336 0.000985103176372027 1092 5418700 SGTC_172 1112-0046 2.638 µM -3.11765239259339 0.0012414777271915 no 3337 0.000911488367089385 1090 2802135 YIL048W NEO1 SGTC_737 1950-0117 57.9 µM -3.14348194747323 0.00114094755139134 no 3338 0.000834753565923172 1090 5393513 SGTC_852 0418-0143 439 µM -3.17647456349362 0.00102339051771704 no 3339 0.000745384311391139 1075 5369229 SGTC_2021 4019055 173 µM -3.19318594050819 0.000968184858867342 yes 3340 0.000703561537851211 1087 44827708 YER133W GLC7 SGTC_806 3966-4455 5.86 µM -3.25717298335273 0.000781142095309832 yes 3341 0.000562639173138942 1091 714982 SGTC_1048 3161-0300 24.5 µM -3.3087957738243 0.000655150944405305 yes 3342 0.000468490786190711 1091 2165101 SGTC_2803 7707263 71.43 µM -3.32267597513864 0.000624630167954205 yes 3343 0.000445792072992578 1091 2199229 SGTC_3202 9113761 49.47 µM -3.36036796302013 0.00054824928293067 yes 3344 0.000389193633859765 1090 4798415 SGTC_1560 lithocholic acid 53.1 µM -3.37508364256386 0.00052084744601249 yes 3345 0.00036896629548578 1091 9903 A bile acid which acts as a detergent. SGTC_513 4245-1575 41.7 µM -3.39993381908485 0.000477434024297588 yes 3346 0.000337010824244669 1089 719745 SGTC_73 0327-0325 16.231 µM -3.40791845398731 0.000464212564753807 yes 3347 0.000327302270224769 1065 53298 SGTC_669 0108-0021 26.2 µM -3.465084676242 0.000379017290202513 yes 3348 0.000265032277576312 1086 17201 SGTC_3132 9126706 49.47 µM -3.48188663177921 0.000356887644190123 yes 3349 0.000248947217707332 1090 850858 SGTC_3293 9120939 62.045 µM -3.6057570453438 0.000227223672282697 yes 3350 0.000155622116373889 1092 934087 SGTC_1369 1866-0067 208 µM -3.74425031283562 0.00013489796883636 yes 3351 9.04666024473156e-05 1085 3531355 SGTC_3141 9094609 49.47 µM -3.75432473452863 0.000129788045994446 yes 3352 8.69047056868598e-05 1086 25236309 YDL196W YDL196W SGTC_1553 gossypol 38.6 µM -4.24982659874545 1.73077993334179e-05 yes 3353 1.06968032960416e-05 1095 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1055 3448-0672 86 µM -4.28793470643862 1.46846448684515e-05 yes 3354 9.01710419081551e-06 1093 748378 SGTC_1558 st069300 45.6 µM -5.05710877307404 3.98610755045205e-07 yes 3355 2.12830238018098e-07 1095 24208000 SGTC_3212 9128307 49.47 µM -7.93321982987938 3.94239103699155e-15 yes 3356 1.0676798070552e-15 1095 27243542