SGTCid condition conc unit OSH2|YDL019C.score OSH2|YDL019C.strain.pval OSH2|YDL019C.strain.significant OSH2|YDL019C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1712 st032288 53.4 µM 11.4738593585819 1.6257915051191e-25 yes 1 8.92580835376615e-31 13 2883011
SGTC_515 4092-1064 102 µM 9.40904007603336 9.25105533243128e-18 yes 2 2.50344256190241e-21 9 717353
SGTC_528 3492-0019 172 µM 8.49928278929147 8.05821329354499e-15 yes 3 9.53828282412038e-18 61 2869262
SGTC_2688 kanamycin b 96.69 µM 8.23849694072288 4.95880251181764e-14 yes 4 8.71937607916071e-17 58 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2021 4019055 173 µM 5.34544303208455 7.17483198948233e-07 yes 5 4.50980817777977e-08 58 44827708 YER133W GLC7
SGTC_520 3584-0023 682 µM 5.2358236359294 1.17494068733402e-06 yes 6 8.2125369070155e-08 9 1340790
SGTC_1563 conessine 56.1 µM 4.49145932024079 2.60346079921421e-05 yes 7 3.53684065023907e-06 8 441082 An anti-amoebic, histamine inhibitor.
SGTC_47 0149-0135 24.25 µM 4.3814854159006 3.96554939876103e-05 yes 8 5.89364675448933e-06 15 5239155
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 4.34992654926128 4.46671465739957e-05 yes 9 6.8091569778946e-06 15 688761
SGTC_1512 0259-0544 12.2 µM 4.33765930495177 4.67721510907328e-05 yes 10 7.20040755234596e-06 8 18476
SGTC_2896 9052656 71.43 µM 4.20242649005277 7.71032687354151e-05 yes 11 1.32034507192625e-05 95 6469436
SGTC_54 0159-0055 9 µM 4.15434955010512 9.1781788524263e-05 yes 12 1.63107085208049e-05 42 3319099
SGTC_1951 sophoraflavanone G 9.2 µM 3.9570031082058 0.000184178772087669 yes 13 3.79479718213325e-05 21 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_3337 9144342 33.5465 µM 3.93661207665777 0.000197580969908842 yes 14 4.1320016749521e-05 27 17682949
SGTC_1810 st050138 53 µM 3.92043102673952 0.000208858791771114 yes 15 4.41953661743051e-05 11 3444541
SGTC_2078 5212016 200 µM 3.89472592794832 0.00022801781812726 yes 16 4.91549118617989e-05 16 1899708
SGTC_146 3448-8650 53.125 µM 3.85164018369872 0.000263850942824102 yes 17 5.86646667926694e-05 144 2891488 YIL048W NEO1
SGTC_1572 epiandrosterone 68.9 µM 3.80553356670589 0.000307965372955487 yes 18 7.07494109120853e-05 32 441302 A steroid.
SGTC_2338 7999974 200 µM 3.80137189687779 0.000312267820396871 yes 19 7.19485651623247e-05 28 315925
SGTC_1597 7-benzyloxygramine 47.5 µM 3.77973597292427 0.000335550934371082 yes 20 7.84973727358761e-05 133 260807
SGTC_3345 9148410 3.559 µM 3.69374208608067 0.000444977132965419 yes 21 0.000110488967894863 10 4903596
SGTC_2062 5245942 200 µM 3.64171520922881 0.000526376424487864 yes 22 0.000135413792712513 29 1376160
SGTC_999 SEC7.066 22.7 µM 3.61510682737741 0.000573139307141028 yes 23 0.000150111898134491 58 740511 YDR170C SEC7
SGTC_2516 gossypol 71.55 µM 3.59480374177394 0.000611372133751541 yes 24 0.000162318102041669 21 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1439 4092-1168 46 µM 3.58011141908561 0.0006404936882826 yes 25 0.000171723865633431 20 2886240
SGTC_1569 carminic acid 40.6 µM 3.50906588358804 0.000800242014940681 yes 26 0.000224841748501444 33 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_363 0455-0021 3.06 µM 3.47183849788758 0.000897890077811713 yes 27 0.000258453602732969 87 4597466
SGTC_152 4469-0003 551.229 µM 3.31363931874107 0.00144733311819568 no 28 0.0004604510799947 40 697280
SGTC_425 3825-7017 13.1 µM 3.30397500203053 0.00148924448705229 no 29 0.000476621658679771 46 3397440
SGTC_2956 9076196 2.52 µM 3.29433534790171 0.0015321491691054 no 30 0.000493273616739152 50 16423868
SGTC_2761 levamisole 97.89 µM 3.29248531393789 0.00154051120866503 no 31 0.000496530420730755 36 26879 An alkaline phosphatase inhibitor.
SGTC_260 nsc-65238 3.989 µM 3.26887307657268 0.00165095419855932 no 32 0.000539883626276549 34 3246252
SGTC_1800 st050079 29.0735 µM 3.26558098654343 0.0016669126584572 no 33 0.000546198814159021 189 3645560
SGTC_401 neomycin 50 µM 3.26437691857591 0.00167278439722512 no 34 0.000548525580217438 22 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1412 3909-8563 178 µM 3.24560136857403 0.00176681487016991 no 35 0.000586014147078697 28 23767530
SGTC_2333 9017922 200 µM 3.18264368303374 0.00211827534223632 no 36 0.000729685433942845 56 3163164
SGTC_1328 1441-0025 69.2 µM 3.16287007790707 0.00224108875460565 no 37 0.000781110170149985 26 4562601
SGTC_1624 st003710 6.25 µM 3.13266090851031 0.00244120607726639 no 38 0.000866147228987595 82 24207033
SGTC_531 3788-1495 174 µM 3.12801602990525 0.00247337033963917 no 39 0.000879952913480898 55 2896655
SGTC_121 0557-0495 61.343 µM 3.11307900033195 0.00257941909720727 no 40 0.000925732254199174 120 3104427
SGTC_736 0958-0254 92.6 µM 3.08971853042645 0.00275352784749849 no 41 0.001001731303144 73 6812352
SGTC_275 trichlorophene 5.69 µM 3.08195865528781 0.00281366825047079 no 42 0.00102821698981103 291 62616
SGTC_2058 5236698 133 µM 3.05847014125221 0.00300299846237368 no 43 0.00111235124049131 65 766665
SGTC_2051 5263410 176 µM 3.04007690812989 0.00315918924552268 no 44 0.00118258871760832 48 227584
SGTC_1818 st052136 56.3 µM 3.03496434304951 0.00320388353840906 no 45 0.00120282063003177 104 674169
SGTC_371 0195-0006 7.36 µM 3.0238524233075 0.00330299219181941 no 46 0.00124789075558321 53 3928593
SGTC_2762 leflunomide 42.06 µM 3.00412330028601 0.00348577199256564 no 47 0.00133173679932471 74 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2036 5160441 105 µM 2.98994917018082 0.00362264244285135 no 48 0.00139511937207357 128 134534 YIL048W NEO1
SGTC_1476 4112-3294 3.34 µM 2.94936815637094 0.00404156995733148 no 49 0.00159212202222441 54 704369
SGTC_1071 trifluoperazine 6.31 µM 2.9322545928292 0.00423087634842024 no 50 0.00168255379229568 68 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1121 fusaric acid 630.51 nM 2.91787996371735 0.00439597132597168 no 51 0.00176209993722219 84 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1502 4534-4282 27.7 µM 2.88232052457542 0.00482936451648425 no 52 0.00197378974898403 50 3278949
SGTC_1238 0333-0287 48.8 µM 2.86914653685057 0.00499935224082938 no 53 0.00205790533732268 81 7226
SGTC_2227 7312221 64.1025 µM 2.85003102236358 0.00525548298302281 no 54 0.00218574825487126 18 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2305 7443522 69.23 µM 2.82020597914712 0.00567846081677752 no 55 0.00239964160605783 64 5415886
SGTC_95 0471-0001 561.058 µM 2.78098721643233 0.00628053187199369 no 56 0.00270969355733266 90 4015405
SGTC_1743 st037606 46.3785 µM 2.76992041573076 0.00646034736417116 no 57 0.00280349954686006 97 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2962 9082311 13.18 µM 2.76744523256245 0.00650118246229912 no 58 0.00282487686708862 86 16459453
SGTC_812 4251-0442 148 µM 2.76428872174977 0.00655358910464863 no 59 0.00285235187211422 47 5723007
SGTC_2033 5192550 145 µM 2.76257549525992 0.00658218943886994 no 60 0.0028673648868971 66 182073
SGTC_2092 5303694 80.6725 µM 2.75024706013553 0.0067912730987748 no 61 0.00297751734132707 107 1963699
SGTC_1524 corynanthine 62.1 µM 2.74993654455523 0.00679661418609025 no 62 0.00298034032145729 89 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2071 5230951 39.92 µM 2.69960486501184 0.00771295495139268 no 63 0.00347109367617038 79 1799272
SGTC_2224 6650123 117.647 µM 2.69661421311994 0.00777067478768872 no 64 0.00350241856435747 37 2908370
SGTC_2706 st078239 82.5 µM 2.68754509093775 0.00794804011624362 no 65 0.00359896916266945 78 15434492
SGTC_2699 st077704 54.6 µM 2.68217440842391 0.00805474483693316 no 66 0.00365726573323034 126 645852
SGTC_1963 st076565 50.3 µM 2.67872424011334 0.00812395522810647 no 67 0.00369516146694638 72 4914280
SGTC_2510 benzyl isothiocyanate 8.31 µM 2.67391436762252 0.00822131320371283 no 68 0.00374857962639589 79 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1376 2910-0861 41.3 µM 2.66497318918603 0.00840502035859632 no 69 0.00384972304591909 101 1112859
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 2.64760564847271 0.00877217879497428 no 70 0.00405320129254358 81 6708784 An antioxidant flavonoid
SGTC_156 3474-0145 5.642 µM 2.6256472999634 0.00925646267898572 no 71 0.00432421899480208 136 2265471
SGTC_3175 9106517 49.47 µM 2.61377368141933 0.00952795406842271 no 72 0.00447741660654207 78 41468073
SGTC_2222 6885208 172.143 µM 2.61062630945984 0.00960107612108907 no 73 0.00451882951154913 38 609514
SGTC_518 1021-0119 62.6 µM 2.58630969531705 0.0101827392519732 no 74 0.00485048617879636 138 1097762
SGTC_3243 9134147 49.47 µM 2.58217989692297 0.0102845210619277 no 75 0.00490891964567204 35 24282180
SGTC_2558 carylophyllene oxide 100 µM 2.57551854898164 0.0104505645831304 no 76 0.00500449522997968 98 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1648 st011736 69.8 µM 2.57540363822702 0.0104534492772144 no 77 0.00500615838652143 81 2855514
SGTC_662 k832-1615 104 µM 2.55523837633133 0.010970542370714 no 78 0.00530575494982736 108 5878478
SGTC_1809 st050081 57.6 µM 2.51921305946292 0.0119498650940485 no 79 0.00588087310814852 112 5036894
SGTC_1627 st003713 25.6 µM 2.51525828493525 0.012061857575161 no 80 0.0059472604297748 230 16195070 YER133W GLC7
SGTC_1372 2752-0194 270 µM 2.51370834475918 0.0121059968175086 no 81 0.00597345940882176 91 823334
SGTC_2673 kobusone 100 µM 2.5118927449286 0.0121578795447336 no 82 0.00600427898520357 52 6710676 An epoxy ketone and protein crosslinker.
SGTC_669 0108-0021 26.2 µM 2.51071857681945 0.0121915351953295 no 83 0.00602428531861675 223 17201
SGTC_3172 9105863 49.47 µM 2.50956912500697 0.0122245605757727 no 84 0.00604392773060502 34 2348785
SGTC_1225 1216-0074 20.6 µM 2.5076744882499 0.0122791653913785 no 85 0.00607642814982607 110 4241466
SGTC_627 1391-0720 175 µM 2.48398275022829 0.0129800249211647 no 86 0.00649610506600156 99 997839
SGTC_838 0109-0203 71.4 µM 2.45855472716428 0.0137704715476057 no 87 0.00697487566974382 100 759422
SGTC_2098 5376439 882.5 nM 2.45651249280868 0.0138357200386118 no 88 0.00701464620747946 103 2844116
SGTC_2537 larixol 68.93 µM 2.44155860284151 0.0143216644822391 no 89 0.00731200730548789 144 6708759
SGTC_944 3370-0224 231 µM 2.41831225614187 0.0151062525593777 no 90 0.00779634484833312 138 4580514
SGTC_2304 7443016 91.4 µM 2.41418666709695 0.0152492873473252 no 91 0.00788519029047835 101 939854
SGTC_6 0844-0013 19.835 µM 2.41372037381774 0.0152655267412842 no 92 0.00789528781706803 326 1584900
SGTC_1777 st045864 34.765 µM 2.41087885631162 0.0153648084388853 no 93 0.00795706671775062 102 4691462
SGTC_1428 4049-0204 61.7 µM 2.39369180648446 0.0159772135499906 no 94 0.00833987880780902 116 X1428
SGTC_1199 1638-0010 4.46 µM 2.38729270114777 0.016210511302774 no 95 0.00848648593006218 149 3111136
SGTC_647 0140-0236 81 µM 2.38657142050216 0.0162369897657642 no 96 0.00850315187719213 128 990837
SGTC_3201 9113999 49.47 µM 2.38270134576805 0.0163796951144299 no 97 0.00859306538182136 152 16649224
SGTC_1477 0139-0234 16 µM 2.37022293392947 0.016847161456535 no 98 0.00888868124317412 112 620880
SGTC_1266 0828-0227 32.9 µM 2.36975323283739 0.0168649779758564 no 99 0.00889998049224534 136 3913820
SGTC_2100 5377183 190 µM 2.36080551578897 0.0172074690179083 no 100 0.00911764550336605 122 2844202
SGTC_893 0958-0369 48.9 µM 2.35824306078789 0.0173066398319929 no 101 0.00918083299381374 161 6819948
SGTC_1325 1431-0015 227 µM 2.35495090039494 0.0174347675218741 no 102 0.00926257664466595 122 1103340
SGTC_1233 0325-0408 14.2 µM 2.34666880177992 0.0177606856847639 no 103 0.00947104194378741 126 12874
SGTC_3091 9116372 49.47 µM 2.33689600534006 0.0181519381678923 no 104 0.00972229605666295 135 17169793
SGTC_2217 6934799 96.0675 µM 2.32264394487999 0.0187356714964635 no 105 0.0100991439503355 88 675606
SGTC_2978 9011784 42.97 µM 2.31829084470852 0.0189171195935884 no 106 0.0102167598252196 204 2994934
SGTC_1184 1269-1718 139 µM 2.31750820490341 0.0189499000087648 no 107 0.0102380321100972 129 5403821
SGTC_3182 9108849 49.47 µM 2.31652449701371 0.0189911705618372 no 108 0.0102648242417817 145 17133045
SGTC_1431 4049-0260 9.09 µM 2.31014204418973 0.0192608016506249 no 109 0.0104401457012066 129 3854841
SGTC_101 0490-5701 117.494 µM 2.30776844351987 0.0193619026635254 no 110 0.0105060094815959 110 4661669
SGTC_1803 st050068 52.4 µM 2.30487562488932 0.0194857285473363 no 111 0.0105867700571843 394 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2715 st079500 56.4 µM 2.30341807024054 0.0195483729874352 no 112 0.0106276660021506 119 28246688
SGTC_1057 3448-5381 134 µM 2.29428035764908 0.0199450137851763 no 113 0.0108872000472227 159 5497911
SGTC_3316 9136639 10.545 µM 2.27669824221874 0.0207274282852634 no 114 0.011402125784566 126 4903665
SGTC_3079 9117512 49.47 µM 2.26842191021399 0.0211046344806621 no 115 0.0116517517994104 59 7185044
SGTC_1706 st031321 9.9705 µM 2.26630210236595 0.0212021768831711 no 116 0.0117164463992993 108 6103185
SGTC_2267 7931562 200 µM 2.24922441550409 0.0220019999028612 no 117 0.0122491109258861 140 934880
SGTC_833 3852-0053 558 µM 2.2357476568934 0.022651023475406 no 118 0.0126841526915298 162 3123681
SGTC_2855 9016525 58.44 µM 2.22456571579922 0.0232017125804517 no 119 0.0130552031645199 168 43811474
SGTC_472 calcifediol 10 µM 2.21491070117672 0.0236862300089377 no 120 0.0133830972259775 110 5283731 A vitamin D metabolite.
SGTC_2063 5246145 200 µM 2.18641224633777 0.0251662422399206 no 121 0.0143927292284252 199 711240
SGTC_2314 7727897 200 µM 2.18405519580839 0.0252920473935604 no 122 0.0144790962124614 151 900724
SGTC_741 4582-0002 126 µM 2.18343876761585 0.0253250353979508 no 123 0.0145017568168255 170 2912688
SGTC_843 0310-0051 143 µM 2.17028284858388 0.0260377101819546 no 124 0.0149927125623624 159 2065037
SGTC_3184 9108758 49.47 µM 2.16439150899748 0.0263622485112222 no 125 0.0152171574696595 116 902885
SGTC_1221 2958-7315 257 µM 2.15638785570661 0.0268085591323546 no 126 0.0155266960824865 170 4562705
SGTC_187 1488-2104 32.728 µM 2.14803082634977 0.0272812907013024 no 127 0.0158556533363611 191 2852859
SGTC_2464 5717415 7.67 µM 2.14786438665881 0.0272907758552111 no 128 0.015862265130455 184 5285744
SGTC_1076 itraconazole 331 nM 2.14749405874025 0.027311890169567 no 129 0.0158769848394704 181 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_998 3996-0085 177 µM 2.14188893150117 0.0276331347818018 no 130 0.0161012103773037 191 715391
SGTC_2468 5987765 72.9 µM 2.13452596153387 0.0280599058990912 no 131 0.0163998754094816 153 26772094
SGTC_1163 k060-0048 49.9 µM 2.1320276871901 0.0282059517427695 no 132 0.0165022852590906 210 6809982
SGTC_254 nsc-64875 3.808 µM 2.1305065935828 0.0282951824069547 no 133 0.0165649060176847 163 56993
SGTC_1546 5-methoxyflavanone 78.7 µM 2.12676450785022 0.0285157016584197 no 134 0.0167198273245956 158 147795
SGTC_3333 9141820 12.094 µM 2.12360615586048 0.0287029326122564 no 135 0.0168515451870298 154 1939433
SGTC_1781 st038725 66.3 µM 2.11210325276162 0.0293935006100507 no 136 0.0173387970361346 306 4270275 YIL048W NEO1
SGTC_1229 0139-0193 12.2 µM 2.10440254913204 0.0298634722508689 no 137 0.0176716736243012 190 3090752
SGTC_3285 9112818 20.8695 µM 2.09878587688087 0.0302101731373409 no 138 0.0179178901861058 212 17017947 YPR165W RHO1
SGTC_1774 st048371 48.465 µM 2.09425510201587 0.030492269942184 no 139 0.0181186307897272 228 4242727
SGTC_486 niguldipine 82 µM 2.08819083379133 0.0308732572792379 no 140 0.0183903119145749 144 1236 A calcium channel blocker.
SGTC_2234 tolnaftate 200 µM 2.08628489007329 0.0309938087727035 no 141 0.018476412273803 84 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_661 1304-0007 33.6 µM 2.08142437650314 0.0313030018923362 no 142 0.0186975396890139 182 3117130
SGTC_847 0342-0274 5.54 µM 2.07418330695921 0.0317683570319841 no 143 0.0190311449741905 186 18097
SGTC_308 4092-1169 104 µM 2.06117959041619 0.0326183990606315 no 144 0.0196429549517756 251 2268590 YDL196W YDL196W
SGTC_1065 prochlorperazine maleate 2.48 µM 2.06011542466341 0.0326887852931552 no 145 0.0196937538154266 210 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_3280 9140961 49.47 µM 2.05867600821824 0.0327841906509378 no 146 0.0197626430178624 166 4901226
SGTC_3329 9141233 27.5565 µM 2.0539186572832 0.0331011450915945 no 147 0.0199917826160508 189 4909101 YNL103W MET4
SGTC_463 ikarugamyin 104 µM 2.05007433749291 0.0333591101805678 no 148 0.0201785886057269 98 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1646 st011709 75.6 µM 2.04763861098219 0.0335234096320344 no 149 0.0202977115594165 156 5757843
SGTC_1788 fluconazole 20 µM 2.03860863814125 0.0341383394747182 no 150 0.0207445512149379 240 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_380 3970-0968 6 µM 2.03338848726741 0.0344980354279472 no 151 0.021006644777185 198 2891601
SGTC_1150 3909-7983 10.9 µM 2.02597581833791 0.0350141517684309 no 152 0.0213836313689562 248 23965914
SGTC_1568 digitonin 820 nM 2.02303065357606 0.0352209639266821 no 153 0.0215349936160635 237 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1906 st060206 94.7 µM 2.02240559301772 0.0352649849068944 no 154 0.0215672338686554 219 5133468
SGTC_3080 9117754 49.47 µM 2.0193938977075 0.0354777218353797 no 155 0.02172314764943 231 9550191
SGTC_824 1304-0008 100 µM 2.01732125598698 0.0356247372729114 no 156 0.0218309994026796 260 768245
SGTC_312 4092-0653 6.84 µM 2.01425655716079 0.0358430354893667 no 157 0.0219913022447266 312 1148278
SGTC_2427 5545055 42.75 µM 2.01091725346261 0.0360821402266595 no 158 0.0221670988102965 229 5372858
SGTC_707 0865-0008 204 µM 2.01073097852177 0.0360955164762434 no 159 0.0221769400177998 175 723043
SGTC_2961 9083290 32.55 µM 2.01057423576529 0.0361067751899679 no 160 0.0221852238483181 192 17741490
SGTC_2878 9043973 25.97 µM 2.01011706952749 0.0361396295219299 no 161 0.0222093999293029 174 6465167
SGTC_122 0236-0016 402.397 µM 2.00648677189784 0.0364013913754973 no 162 0.0224021693466005 274 6808838
SGTC_2703 st077852 53.4 µM 1.99808975821161 0.0370128044446972 no 163 0.0228534649511567 216 6281836
SGTC_1976 st070609 63.5 µM 1.9968006010506 0.0371074111392043 no 164 0.022923424134107 202 682556
SGTC_2429 5902844 64.44 µM 1.99176819068721 0.0374786152360449 no 165 0.0231982489408732 257 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.98359596407407 0.0380878771179835 no 166 0.0236504497475988 208 7104
SGTC_1575 cyproterone acetate 48 µM 1.98261913460942 0.0381612399407693 no 167 0.0237049941936984 236 9880 An androgen receptor antagonist and liver toxin.
SGTC_712 r015-0009 80.6 µM 1.96624669350591 0.0394081030031539 no 168 0.0246350605663007 195 6813872 YLR060W FRS1
SGTC_1879 gemcitabine 100 µM 1.95347478914601 0.0404036067671785 no 169 0.025381680883641 220 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1672 st016598 6.51 µM 1.95163277695812 0.0405488525182908 no 170 0.0254909094428141 289 4665860 YNL267W PIK1
SGTC_1754 st042065 16.137 µM 1.94337859035011 0.0412049224257378 no 171 0.0259852160659544 439 1126236 YIL048W NEO1
SGTC_2607 solasodine 47.35 µM 1.92023855543343 0.0430901489080678 no 172 0.0274138868129569 286 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_3141 9094609 49.47 µM 1.91821438749539 0.0432583201006441 no 173 0.0275419163250826 258 25236309 YDL196W YDL196W
SGTC_2872 9044037 25.97 µM 1.91782101349392 0.0432910636884733 no 174 0.0275668551631834 160 6465195
SGTC_2465 5809242 33.21 µM 1.91345344960963 0.0436559564138715 no 175 0.0278450137080311 148 2731748
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.91071974299653 0.043885606917001 no 176 0.0280203031249755 330 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_236 1509-0011 5.31 µM 1.9011505845853 0.0446971684065045 no 177 0.0286411457494024 625 3107280
SGTC_2470 5664817 21.68 µM 1.89718761000902 0.045036788747049 no 178 0.0289015907530572 208 2859561
SGTC_2047 4141938 200 µM 1.89565769338299 0.0451684544493586 no 179 0.0290026615067501 199 3807862
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.89212534076537 0.0454736344131699 no 180 0.0292371413585362 228 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2635 hydroquinidine 100 µM 1.89023568283458 0.0456375721890207 no 181 0.0293632231819943 235 442912 An experimental heart treatment.
SGTC_1316 1272-0050 65.9 µM 1.8877836434589 0.0458510074261467 no 182 0.0295275009515679 210 7340392
SGTC_1104 tacrolimus 29.8 µM 1.88670025093957 0.0459455653618187 no 183 0.0296003269583069 260 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_917 harmaline 728.087 nM 1.88643268597846 0.045968942401899 no 184 0.029618335700846 283 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2614 arthonioic acid 13.39 µM 1.88329906620515 0.0462434373921707 no 185 0.0298299249557003 233 6710684
SGTC_37 0566-0070 1.56 µM 1.87975952479365 0.0465550711615907 no 186 0.0300704295039099 287 1626686
SGTC_1452 4194-0072 190 µM 1.87810427819936 0.0467013821922312 no 187 0.0301834505993635 270 1343545
SGTC_1527 coumarin 137 µM 1.87422415612498 0.0470458012176117 no 188 0.0304497680064966 259 323 A hepatotoxic, DNA x-linker.
SGTC_621 3584-0052 32.1 µM 1.85955035085085 0.0483667741365846 no 189 0.0314745846425368 272 2273927
SGTC_3275 9138069 49.47 µM 1.85424023336041 0.0488520521035265 no 190 0.0318523992127695 218 17617007
SGTC_2075 5212009 200 µM 1.84969089708263 0.0492708918812431 no 191 0.0321790566283747 213 780898
SGTC_1718 roemerine 11.9335 µM 1.84646783061437 0.0495693587556014 no 192 0.0324121530860738 336 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3092 9117248 49.47 µM 1.84228675550997 0.0499586884535889 no 193 0.0327166080306898 177 17141857
SGTC_3308 9128332 17.569 µM 1.84178342255192 0.0500057213770786 no 194 0.0327534179278284 378 17332805 YDL196W YDL196W
SGTC_1994 st072947 40.9 µM 1.8353374840764 0.0506111756724815 no 195 0.033227850182194 278 5286565 YDL195W SEC31
SGTC_3220 9131269 49.47 µM 1.83478422276862 0.0506634133458043 no 196 0.0332688336084225 201 17722206
SGTC_2251 lansoprazole 556 µM 1.82547644890342 0.0515486863966767 no 197 0.0339645810017588 213 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_887 0885-0007 9.62 µM 1.81852132099278 0.0522181918298822 no 198 0.034492245503964 301 5719458
SGTC_82 0054-0107 293.755 µM 1.81748809629783 0.0523182372733347 no 199 0.0345712046809083 228 3104697
SGTC_566 0958-0068 16.5 µM 1.80866245668292 0.0531790241503285 no 200 0.0352517294825697 240 6815365
SGTC_178 4092-0806 87.505 µM 1.80842292971159 0.0532025413828363 no 201 0.035270350932928 416 2169044
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.80795434918779 0.053248571386923 no 202 0.0353068029345933 225 364106
SGTC_1496 4469-0713 57.4 µM 1.80597769335205 0.0534430914964391 no 203 0.0354609119830158 271 746691
SGTC_795 0685-0265 78 µM 1.8035919936483 0.05367861452344 no 204 0.0356476460631726 305 302754
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.8027515086892 0.053761785146177 no 205 0.035713624396715 281 521171
SGTC_1526 st051518 75 µM 1.79203001564453 0.0548317138866977 no 206 0.036564079035767 276 673993
SGTC_2419 paclitaxel 166.5 µM 1.79016570571222 0.0550194648895344 no 207 0.0367136382307336 374 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_982 1491-0518 27.5 µM 1.78537912854496 0.055503838403552 no 208 0.0370999208638557 256 3091256
SGTC_859 0439-0102 54.6 µM 1.78445216616628 0.0555980294974672 no 209 0.0371751104389113 309 610143
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.78093867649313 0.0559561903250187 no 210 0.037461234682861 296 688664
SGTC_3320 9137005 35.139 µM 1.77938238673966 0.0561154170982413 no 211 0.0375885460544725 251 4908713
SGTC_228 caffeine 993.056 µM 1.77422280132512 0.0566458604619971 no 212 0.0380131520372519 231 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_802 4112-3352 742 µM 1.77269489335199 0.0568036964504487 no 213 0.0381396388777098 325 704594
SGTC_3087 9117406 49.47 µM 1.76911146075818 0.0571752311192529 no 214 0.0384376378457497 270 42546093
SGTC_2990 9074105 71.4286 µM 1.7641647199428 0.0576912547151468 no 215 0.0388521253285435 250 6502001
SGTC_229 benomyl 22.8748 µM 1.7610918590937 0.05801364242297 no 216 0.0391114283465507 320 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_757 1066-0008 322 µM 1.75994904815888 0.0581339004429849 no 217 0.0392082229928556 311 6842497
SGTC_1178 0988-0033 191 µM 1.75720683877982 0.0584232620898695 no 218 0.0394412800136365 335 5392207
SGTC_555 4296-0685 37 µM 1.75559652062174 0.058593711447417 no 219 0.0395786633802049 299 2908540 YHR072W ERG7
SGTC_1016 4226-1401 38 µM 1.75557773851407 0.0585957018014999 no 220 0.0395802680581497 320 2901613
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.75461705090243 0.0586975773996741 no 221 0.0396624164611738 252 6857784
SGTC_931 2812-0076 566 µM 1.75421405014716 0.0587403547686485 no 222 0.0396969183114902 315 3450959
SGTC_1847 st056231 15 µM 1.75343801229732 0.0588227978719107 no 223 0.0397634254933384 373 5393180
SGTC_3143 9086658 49.47 µM 1.75244329628811 0.0589286052124495 no 224 0.0398488060466641 377 25236626
SGTC_1701 st028638 40.4 µM 1.74714245252319 0.0594949730155561 no 225 0.0403063155317056 302 3490878
SGTC_1643 st009866 20.2 µM 1.74455097714546 0.059773407213279 no 226 0.0405315302612069 251 3156273 YOR207C RET1
SGTC_2511 berberine 10.47 µM 1.74314848584747 0.0599245193394194 no 227 0.0406538405447572 275 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2593 nobiletin 86.24 µM 1.73447539304907 0.0608656621077115 no 228 0.0414168840579817 269 72344 An anti-infammatory.
SGTC_2216 7189485 200 µM 1.73323839812581 0.0610008286800006 no 229 0.0415266523816014 231 731273
SGTC_809 3998-0021 90 µM 1.73026879694985 0.0613262751221723 no 230 0.0417911308593962 267 715485
SGTC_2404 5161160 200 µM 1.72587862491254 0.0618098888147999 no 231 0.0421846254734286 352 2831543
SGTC_1929 genistein trimethyl ether 50.5 µM 1.724673246491 0.0619431907456874 no 232 0.0422931875234041 312 136420
SGTC_2214 7179297 48.276 µM 1.72109822861166 0.0623398690838289 no 233 0.0426165003438823 238 769744
SGTC_1734 st037168 69.4 µM 1.72060772147906 0.0623944491876351 no 234 0.0426610156828629 322 708907
SGTC_510 ag-490 170 µM 1.71790502602788 0.0626958542635099 no 235 0.0429069699694996 267 5328779
SGTC_1486 3970-0793 4.53 µM 1.71583774451188 0.0629271628468068 no 236 0.0430958718789446 277 2844330
SGTC_948 3448-0295 75.3 µM 1.71389418587815 0.0631452338680618 no 237 0.0432740805284316 371 678569
SGTC_2911 7942208 15.64 µM 1.71016991457109 0.0635647481077451 no 238 0.043617228652215 283 1243384
SGTC_3355 9151058 44.0485 µM 1.70971938726025 0.0636156437028938 no 239 0.0436588879603003 305 17015728
SGTC_993 3909-8757 62.7 µM 1.70948043956315 0.0636426502376535 no 240 0.0436809959756172 266 4288324 YLR208W SEC13
SGTC_2731 amoxapine 43.43 µM 1.7088995398914 0.0637083423410707 no 241 0.0437347798851569 157 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2952 9073731 13.78 µM 1.70774736875721 0.0638387937893108 no 242 0.0438416143356653 380 16457353
SGTC_1732 st034308 51.822 µM 1.7070083549429 0.0639225759269288 no 243 0.0439102497429556 334 830119
SGTC_1801 st050089 28.441 µM 1.70639745174192 0.063991898678124 no 244 0.0439670523722938 449 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1302 1159-0335 255 µM 1.70484882333441 0.0641678925039921 no 245 0.0441113115365434 300 649284
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.69711847552062 0.0650520399263769 no 246 0.0448371319567509 372 5024745
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.69682600468969 0.0650856755602116 no 247 0.0448647803888216 286 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_499 genistein 192 µM 1.68989753695536 0.0658864379832648 no 248 0.0455237794567652 218 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_749 1000-0129 128 µM 1.68935905468476 0.0659489917997457 no 249 0.0455753213105547 352 708470
SGTC_930 2810-3379 265 µM 1.68750677828781 0.0661645164674058 no 250 0.0457529738329647 373 1015764
SGTC_2735 sertaconazole 140 nM 1.68633492396659 0.066301151019645 no 251 0.0458656539809726 236 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_854 0422-0053 192 µM 1.68612188622255 0.0663260140110555 no 252 0.0458861626505976 315 3596728
SGTC_2359 9039622 200 µM 1.68272993243012 0.0667228520262824 no 253 0.0462136922398552 331 6463596
SGTC_3094 9117742 49.47 µM 1.67860432860691 0.0672079961937742 no 254 0.0466145912010458 358 17149698
SGTC_2775 cyproheptadine 69.59 µM 1.67783825498471 0.0672983809622273 no 255 0.0466893394985948 313 2913 A selective serotonin reuptake inhibitor.
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.67568168945232 0.0675533267629867 no 256 0.0469002791371927 356 16486 A toxic proline analog.
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.67306095966305 0.0678641491012466 no 257 0.0471576480258483 290 688803
SGTC_522 1273-0010 11.6 µM 1.67301955898677 0.0678690681280396 no 258 0.0471617228468841 324 5705015
SGTC_3196 9111891 49.47 µM 1.67243309904476 0.0679387780233134 no 259 0.0472194749156973 291 18891510
SGTC_2334 9017922 200 µM 1.66814458428307 0.0684502163159286 no 260 0.0476435142301364 319 3163164
SGTC_845 0330-0138 4.51 µM 1.66751540813932 0.0685254996014354 no 261 0.0477059815978178 329 9039800
SGTC_1850 st056238 17 µM 1.65724668268268 0.0697632379855342 no 262 0.04873480596322 384 5393177
SGTC_2122 5258151 111.688 µM 1.65490667297534 0.0700476834279782 no 263 0.048971715232957 365 2173356
SGTC_2009 4012297 12.05 µM 1.654412331336 0.0701078882997809 no 264 0.0490218813232477 364 45595307
SGTC_174 3553-0389 74.3 µM 1.65170643541562 0.0704381394013043 no 265 0.0492972050733562 298 738071
SGTC_338 4055-0136 114 µM 1.64055923258093 0.0718112652709315 no 266 0.0504444716979088 352 2900563
SGTC_220 paclitaxel 373.376 µM 1.6380627147324 0.0721215847429623 no 267 0.0507043059277498 268 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2656 pseudo-anisatin 100 µM 1.63518682559789 0.0724803333505749 no 268 0.0510049445327891 261 6708809 A neurotoxin.
SGTC_1492 4158-0558 28.5 µM 1.63440234264352 0.0725784294543142 no 269 0.0510871983408728 333 3967268
SGTC_1549 4'-methoxyflavonol 74.6 µM 1.63177833838882 0.0729072885267872 no 270 0.0513630950867035 335 97141
SGTC_894 0960-0238 55.9 µM 1.62694222347364 0.0735163719535737 no 271 0.051874684609787 324 6741907 YDL195W SEC31
SGTC_3053 9095903 49.47 µM 1.62677523414903 0.0735374726738551 no 272 0.0518924216778906 309 17174018
SGTC_51 1013-0126 23.419 µM 1.61672196113535 0.074816351656448 no 273 0.0529691556170023 343 1627850
SGTC_347 4534-1311 26.2 µM 1.6166041215466 0.0748314420327953 no 274 0.0529818808396024 352 2862016
SGTC_1725 st036284 20.55 µM 1.61369666040728 0.0752045034083917 no 275 0.0532966193471544 419 707914
SGTC_2586 curcumin 80 µM 1.61232116583418 0.0753814888544733 no 276 0.0534460348972799 448 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2922 7999257 32.47 µM 1.61221102518167 0.0753956744135591 no 277 0.0534580134609842 313 2988377
SGTC_132 0417-1715 25.805 µM 1.60927426255317 0.0757746654197624 no 278 0.0537781921407591 373 6769098
SGTC_1961 st076550 68.7 µM 1.60583199065844 0.0762207379004792 no 279 0.054155414825366 316 1579337
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.60489823750591 0.0763420837643337 no 280 0.0542581007507873 353 5355888
SGTC_1360 1598-0022 39.8 µM 1.60482835773082 0.076351170897304 no 281 0.0542657917032393 455 761525
SGTC_63 0099-0242 26.702 µM 1.60193644501726 0.0767279561120993 no 282 0.0545848321389444 450 3898502 YLR359W ADE13
SGTC_461 N-acetylfarnesylcysteine 136 µM 1.60061393620517 0.0769007352571456 no 283 0.0547312268229837 254 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2924 9010168 62.78 µM 1.59425293131741 0.077735903397255 no 284 0.0554396976909843 403 2993929
SGTC_2449 5812982 45.77 µM 1.59306326472909 0.077892862073282 no 285 0.055572999641535 318 776185
SGTC_488 nitrendipine 139 µM 1.58646879093481 0.0787672684214208 no 286 0.056316503158413 378 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1736 st036774 51 µM 1.58329961465666 0.0791901281560559 no 287 0.0566765953604019 393 1272247
SGTC_848 0368-0089 85.6 µM 1.57939958947562 0.079712860674631 no 288 0.0571222157408455 390 762535
SGTC_2103 5378138 10 µM 1.57767508259553 0.079944832262573 no 289 0.0573201367511027 413 244142
SGTC_1865 st057639 52.2 µM 1.57681512693145 0.0800606995436641 no 290 0.0574190349756933 389 688818
SGTC_1324 1418-0026 34.4 µM 1.56938012890528 0.0810677632599651 no 291 0.0582796957042161 402 1372513
SGTC_3331 9141060 1.957 µM 1.56932432935416 0.0810753572361323 no 292 0.0582861930521427 358 4906567 YPR165W RHO1
SGTC_2170 morpholine 200 µM 1.56525687813994 0.0816303593805933 no 293 0.0587613448832651 329 121171 Reacts with secondary amines.
SGTC_1603 st002045 67.8 µM 1.56320748005823 0.0819110819245206 no 294 0.0590019006582473 373 5887985
SGTC_1366 1683-0113 21.9 µM 1.55741867747754 0.0827079501428076 no 295 0.0596855572679437 363 708623
SGTC_1953 st076800 12.1 µM 1.55478721945837 0.0830721112215504 no 296 0.0599983769832868 435 297591
SGTC_3055 9094636 49.47 µM 1.55287940991314 0.0833368814579087 no 297 0.0602259733467448 352 25236176
SGTC_2810 7959871 45.46 µM 1.55061085058508 0.08365254243164 no 298 0.0604974851318516 462 2974535
SGTC_826 1683-5028 118 µM 1.54817105986066 0.0839930312330451 no 299 0.0607905585624646 372 722377
SGTC_3268 9137683 49.47 µM 1.5441206001165 0.0845605957063879 no 300 0.0612795596064029 327 1953228
SGTC_1298 1079-1278 263 µM 1.5437109328384 0.0846181595228168 no 301 0.0613291882839444 415 2840950
SGTC_3223 9129970 49.47 µM 1.54024366472421 0.0851065353656755 no 302 0.061750485026814 421 17248386
SGTC_868 0527-0199 213 µM 1.53988904831495 0.0851566030506575 no 303 0.0617937003852201 409 2849450
SGTC_2930 9013230 14.89 µM 1.53501891587129 0.0858464433892257 no 304 0.0623895908418349 448 2995857
SGTC_2723 salbutamol 83.58 µM 1.53366460244056 0.0860390192841968 no 305 0.0625560931488154 284 9884233 β2-adrenoceptor agonist
SGTC_1547 harmine 94.2 µM 1.53317662830617 0.0861084856662902 no 306 0.0626161705943925 480 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2722 naftopidil 47.16 µM 1.53256436444003 0.086195704862707 no 307 0.0626916137036125 397 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1241 0364-0022 50.8 µM 1.5320393333635 0.0862705500489167 no 308 0.0627563644001875 431 4563895
SGTC_2145 5634607 200 µM 1.53155454982441 0.0863397009446202 no 309 0.0628161977398478 346 308662
SGTC_155 k072-0202 43.6 µM 1.53096767354083 0.0864234700911812 no 310 0.0628886911183814 365 5857737
SGTC_231 b-estradiol 524 µM 1.53014093636377 0.086541579418654 no 311 0.0629909236669811 326 450 A steroid.
SGTC_1887 st057648 70.8 µM 1.53001346948817 0.086559800322654 no 312 0.063006697459726 400 688672
SGTC_2152 5568786 200 µM 1.52826748346407 0.0868096711122432 no 313 0.0632230698755166 402 5399883
SGTC_2821 7996764 71.43 µM 1.52547061763458 0.0872110575179967 no 314 0.0635708783872101 442 2987135
SGTC_2332 7982454 138.89 µM 1.52533585830586 0.0872304321589552 no 315 0.0635876741121451 453 2981748
SGTC_1975 st070967 30.8 µM 1.5221298025511 0.0876923219879389 no 316 0.0639882799065294 448 261391
SGTC_913 3487-1245 167 µM 1.51697087246856 0.0884393849459265 no 317 0.0646370191104268 427 4016153
SGTC_1587 estradiol valerate 56.1 µM 1.51251719342296 0.0890881259122435 no 318 0.0652011710317945 417 13791 A steroid.
SGTC_364 0083-0097 67.7 µM 1.50870402874924 0.089646375682912 no 319 0.0656872177662237 413 5207356
SGTC_743 1275-0778 158 µM 1.5079294441577 0.0897600925190951 no 320 0.0657862929193544 439 2849257 YMR203W TOM40
SGTC_2560 caryophyllene 100 µM 1.50648270628223 0.0899727753685617 no 321 0.0659716516553653 463 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_574 1315-0397 40 µM 1.5025926226129 0.0905465078727936 no 322 0.0664720634841094 504 6794277
SGTC_866 0495-0101 262 µM 1.5011040617097 0.0907667666231172 no 323 0.0666643242212532 371 635694
SGTC_3290 9121031 71.43 µM 1.49919752818696 0.0910494521857002 no 324 0.0669111980558258 370 17014854
SGTC_1657 st012939 43.4 µM 1.49318450477552 0.0919452924626756 no 325 0.0676944485167802 372 24207257
SGTC_327 1273-0057 3.96 µM 1.49291663664222 0.0919853516826619 no 326 0.0677295048499464 403 3108138
SGTC_1457 k015-0032 57.3 µM 1.48733648720175 0.0928227947717554 no 327 0.0684629811611168 444 4302660
SGTC_1046 2001-0062 216 µM 1.48477249053229 0.0932094724276719 no 328 0.0688020507437846 441 739778
SGTC_2728 chlorpromazine 9.18 µM 1.48261201270281 0.0935362181685934 no 329 0.0690887618313653 315 2726 A thorazine and dopamine antagonist.
SGTC_3110 9122132 49.47 µM 1.47494648177376 0.0947023607856732 no 330 0.0701134661670794 433 918317
SGTC_1651 st011928 86.1 µM 1.47363144641095 0.09490348674608 no 331 0.0702904248742713 426 720198
SGTC_483 fpl-64176 144 µM 1.47167139196984 0.0952038479446701 no 332 0.0705548182571077 347 3423
SGTC_1109 tnp00067 928.257 nM 1.46918299925812 0.0955861800838431 no 333 0.0708915800995602 424 676295
SGTC_289 k017-0060 526 µM 1.46698495360729 0.0959248402812345 no 334 0.071190074245915 385 5512909
SGTC_2343 7990716 14.84 µM 1.46650349873651 0.0959991373025182 no 335 0.0712555843679735 438 6456862
SGTC_768 0384-0033 77.3 µM 1.46267047479946 0.0965921508684479 no 336 0.071778784450138 534 3965305 YMR134W ERG29
SGTC_524 r073-0010 27.8 µM 1.461630429742 0.0967535211594921 no 337 0.0719212555058431 425 2772106
SGTC_3023 9089636 49.47 µM 1.46137069149004 0.096793852250955 no 338 0.0719568696877367 429 17249241
SGTC_739 1486-1183 203 µM 1.45893408011845 0.0971728005536138 no 339 0.0722916259939119 454 4346692
SGTC_3130 9127414 49.47 µM 1.45684258293596 0.0974989431685546 no 340 0.0725799191663086 399 1494646
SGTC_170 4197-0004 226 µM 1.45307996412836 0.0980876961904174 no 341 0.0731007766482719 388 218692
SGTC_2734 clemastine 41.6 µM 1.45016061829379 0.0985462901322074 no 342 0.073506867117728 269 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2482 5981709 142.65 µM 1.44052108907861 0.100071689711853 no 343 0.0748600139438452 495 877755
SGTC_827 3253-0474 693 µM 1.43765702439258 0.100528216244626 no 344 0.0752656962231551 484 5402065
SGTC_2049 5262831 67.185 µM 1.43629978394507 0.100745087678623 no 345 0.0754585277550818 446 763417
SGTC_314 1671-0008 2.74 µM 1.43418635221818 0.101083468789801 no 346 0.0757595453289419 520 3913060
SGTC_776 4476-4378 112 µM 1.43076452032124 0.101633092701931 no 347 0.0762488573526632 428 2892008
SGTC_2534 helenine 20.12 µM 1.4300654705365 0.101745643155973 no 348 0.0763491146566265 407 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_298 1391-0729 10 µM 1.42951617712043 0.101834145740553 no 349 0.0764279643428667 422 3237558
SGTC_3239 9133757 49.47 µM 1.42860273507813 0.101981444285532 no 350 0.076559223801748 417 17036923
SGTC_2168 5727979 200 µM 1.42386772701719 0.102747480877021 no 351 0.0772423828323557 429 695210
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.42285831242495 0.102911324813348 no 352 0.0773886165573094 443 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2733 amorolfine 100 µM 1.42263744126667 0.102947200989362 no 353 0.0774206421465064 321 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1632 st005650 90 µM 1.4225682396988 0.102958443292257 no 354 0.0774306782161269 447 2759605
SGTC_2228 7354201 200 µM 1.42242581986515 0.102981583246645 no 355 0.0774513359927056 417 753451
SGTC_3062 9077494 49.47 µM 1.4182038689453 0.103669270291648 no 356 0.078065626341537 451 16459633
SGTC_3104 9120930 49.47 µM 1.41653283583668 0.103942372717417 no 357 0.078309778688452 406 17014836
SGTC_2714 st079313 56.9 µM 1.41385327250087 0.104381391039543 no 358 0.0787024940986 448 2939799
SGTC_2440 5628896 157.78 µM 1.41296361981555 0.104527447996826 no 359 0.0788332106079126 439 5522048
SGTC_2521 angolensin 13.4 µM 1.4111844333219 0.104819986410585 no 360 0.0790951194683754 432 821428 A flavenoid.
SGTC_2917 7979103 53.79 µM 1.41029208229559 0.104966932089889 no 361 0.0792267277393217 540 2980565
SGTC_370 0180-0345 38.7 µM 1.40891194308005 0.105194496659259 no 362 0.079430603803753 423 3989527
SGTC_69 0096-0274 206.684 µM 1.40704941221391 0.105502166157787 no 363 0.079706368606104 545 6741392
SGTC_2399 5884133 200 µM 1.40224231593661 0.106299251505025 no 364 0.0804214496598778 492 722445
SGTC_3174 9107204 49.47 µM 1.4005928821999 0.10657375089316 no 365 0.0806679253209833 477 3938802
SGTC_1620 st003704 16.5 µM 1.39995130607896 0.106680660340692 no 366 0.0807639502996764 467 2834414
SGTC_891 0929-0073 133 µM 1.39811562706535 0.106986977395843 no 367 0.0810391739407999 465 5603632
SGTC_2037 5169046 200 µM 1.395413771881 0.107438985331872 no 368 0.0814455503573974 450 5718022
SGTC_714 4296-0578 26.1 µM 1.39329660348018 0.10779413852026 no 369 0.081765058661153 365 1589775
SGTC_460 trequinsin 123 µM 1.39142977422044 0.10810799843575 no 370 0.0820475705589972 489 5537 A vasodilator.
SGTC_3046 9092212 49.47 µM 1.39105091153424 0.108171774797488 no 371 0.0821049944513891 456 25236637
SGTC_1884 5633444 25 µM 1.38849012051612 0.108603559276216 no 372 0.0824939255326365 524 5724239
SGTC_1481 3346-2004 36 µM 1.3866221243148 0.108919310100365 no 373 0.0827785091698825 488 2770522
SGTC_738 1315-0003 72.4 µM 1.38440941064522 0.109294182343914 no 374 0.083116564516505 514 6251474
SGTC_1608 st001473 40.5 µM 1.38414959199155 0.109338260885016 no 375 0.0831563272648289 481 7292267
SGTC_1786 berberine 21.6 µM 1.378722916099 0.110261823205017 no 376 0.0839901005877711 505 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_965 1291-5240 308 µM 1.3786604118124 0.110272493260203 no 377 0.0839997403963825 504 2834598
SGTC_2133 5320837 200 µM 1.37787291826131 0.110406989075635 no 378 0.0841212638370694 454 2841355
SGTC_2514 salinomycin 42.74 µM 1.37606023801309 0.11071702311706 no 379 0.0844014922244456 563 23682228 A polyether potassium ionophore.
SGTC_387 norethindrone acetate 66.7 µM 1.37501025118801 0.110896894032113 no 380 0.0845641333026576 448 541197
SGTC_719 2810-4230 27.3 µM 1.37196908691502 0.111419050117949 no 381 0.0850365307017271 432 721079
SGTC_1678 st019265 80.2 µM 1.36260375052162 0.113038088642761 no 382 0.0865037130982436 537 5367020
SGTC_2073 5212005 126 µM 1.36194427627116 0.113152725189844 no 383 0.0866077358004616 396 691789
SGTC_3115 9123671 49.47 µM 1.35820733211741 0.113803885884006 no 384 0.0871989523426404 482 3286988
SGTC_1286 0929-0070 131 µM 1.35280206139723 0.114750469953464 no 385 0.0880594370214912 533 1420408
SGTC_1675 st018485 24.5 µM 1.35268112132829 0.114771713151123 no 386 0.0880787620619035 506 3323024
SGTC_2432 5630864 12.22 µM 1.35121104901661 0.115030155988561 no 387 0.0883139181040472 510 5714970
SGTC_137 0438-0332 85.389 µM 1.34873224348612 0.115466873706278 no 388 0.0887114924842959 663 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_3191 9110352 49.47 µM 1.3483352527281 0.115536925128415 no 389 0.0887752892719071 466 17122424
SGTC_3169 9102970 49.47 µM 1.34707994599192 0.115758630278592 no 390 0.0889772430533946 485 17027839
SGTC_1197 1601-0112 267 µM 1.34371404377803 0.116354587580019 no 391 0.0895204371104016 554 7350313
SGTC_2874 9043904 71.43 µM 1.34031940830542 0.116957833719167 no 392 0.0900707621403946 414 4463428
SGTC_2546 rhodinyl acetate 100 µM 1.33950091667316 0.117103615415824 no 393 0.0902038281131143 532 6708682
SGTC_1905 st060207 84.5 µM 1.33868560232021 0.117248959154986 no 394 0.0903365226614637 512 1948547
SGTC_1387 3342-1166 1.8 µM 1.33834203583389 0.117310244013549 no 395 0.0903924824011045 436 3418228
SGTC_225 nsc-122657 1.016 µM 1.33558927531794 0.117802096382695 no 396 0.0908417787296235 375 275685
SGTC_1249 0481-0015 10.2 µM 1.33553134666524 0.117812462499445 no 397 0.0908512514196277 451 4227577
SGTC_303 1348-1668 34.2 µM 1.33534470408194 0.117845865884983 no 398 0.0908817768334533 486 5380509
SGTC_286 k060-0067 22.9 µM 1.33298263992958 0.118269183170885 no 399 0.0912687504254026 494 5985051
SGTC_1100 amiodarone 5.07 µM 1.33133315897005 0.118565431695093 no 400 0.0915397060789673 549 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.33124751509505 0.118580827733247 no 401 0.0915537908225552 495 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_509 pifithrin 175 µM 1.33009653997264 0.118787873442837 no 402 0.0917432327036675 500 4817 A p53 inhibitor.
SGTC_3102 9121669 49.47 µM 1.32960585431711 0.118876219113599 no 403 0.0918240841181672 468 41905072
SGTC_572 0960-0087 17.7 µM 1.32949446119814 0.118896281388232 no 404 0.0918424459694603 581 6796365
SGTC_2682 pyrogallin 40.03 µM 1.32544794908257 0.11962669353758 no 405 0.09251131125275 579 822798 An ATP competetive kinase inhibitor.
SGTC_1957 st077035 62.4 µM 1.31757589056408 0.121056686882913 no 406 0.0938228303877334 524 705593
SGTC_1224 0823-0416 294 µM 1.31652168607683 0.121249096920834 no 407 0.093999502310044 530 3598164
SGTC_2433 5607874 27.82 µM 1.31633621706826 0.121282970367741 no 408 0.0940306100503898 536 2252428
SGTC_1548 st061468 90.8 µM 1.31343549399061 0.121813614944103 no 409 0.0945181219198889 541 390799
SGTC_32 0928-0142 34.1 µM 1.31250024933816 0.121985051400114 no 410 0.0946757009849358 488 2244242
SGTC_3256 9138902 49.47 µM 1.30570029601281 0.123236623002202 no 411 0.0958272486441082 501 17228773
SGTC_2293 7624732 200 µM 1.30455788353383 0.123447770507553 no 412 0.0960217186713431 499 894453
SGTC_1843 st055809 45.5 µM 1.30237621770052 0.123851702806572 no 413 0.0963939041903981 514 16413835
SGTC_2372 9071633 200 µM 1.29872989103194 0.124528878509459 no 414 0.0970183211026542 591 21321366
SGTC_1262 0737-0114 49.6 µM 1.29619977799663 0.125000275734039 no 415 0.0974533330123794 634 765919
SGTC_1257 0669-0121 16 µM 1.29516289848693 0.125193821247778 no 416 0.0976320203287311 615 4307855
SGTC_3045 9092950 49.47 µM 1.29432519146023 0.125350341672883 no 417 0.0977765592532037 584 44120432
SGTC_302 1094-0063 18.9 µM 1.29224493452604 0.125739615582954 no 418 0.0981361674699817 482 5440289
SGTC_2352 9027995 87.8 µM 1.28992708113832 0.12617434276512 no 419 0.0985379885233737 496 2997347
SGTC_760 0568-0725 82.9 µM 1.28494051466246 0.12711315144015 no 420 0.0994065358937408 571 3916171
SGTC_2800 7887935 81.82 µM 1.283792259822 0.12733001731158 no 421 0.0996073262846927 547 2961002
SGTC_2266 7929956 200 µM 1.28269212946907 0.127538035399511 no 422 0.0997999791971418 580 2967153
SGTC_431 k089-0097 107 µM 1.27423472200993 0.129145095115512 no 423 0.101290121576443 635 5499420
SGTC_1294 1000-1494 117 µM 1.27253572310819 0.129469621552073 no 424 0.101591419951883 550 712797 YDL207W GLE1
SGTC_2572 astragaloside iv 100 µM 1.26765907051213 0.13040424961977 no 425 0.102459863596784 551 45006101 An anti-inflammatory agent.
SGTC_3140 9094243 49.47 µM 1.26708843925731 0.130513917375194 no 426 0.102561834404184 574 19291112
SGTC_1455 4262-0120 131 µM 1.26638172855494 0.130649826181425 no 427 0.102688224608943 595 1529587
SGTC_1417 3966-0327 90.4 µM 1.26518472287307 0.130880247654749 no 428 0.102902558785087 632 651118
SGTC_2618 avocadyne 43.43 µM 1.2629588955231 0.131309461781353 no 429 0.103301976106641 547 3015189
SGTC_2528 xanthyletin 44.79 µM 1.26273394715405 0.131352893385166 no 430 0.103342404883548 542 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1831 st055328 12 µM 1.25993370504462 0.131894376699986 no 431 0.103846639318947 593 1103068
SGTC_523 1934-0222 13.7 µM 1.25756170485367 0.132354253776648 no 432 0.104275155094049 584 1361595
SGTC_2683 piperine 63.03 µM 1.25704764244757 0.132454064355656 no 433 0.104368192220509 552 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1983 st071813 46.9 µM 1.25699292613746 0.132464691151413 no 434 0.104378098544182 574 11838595
SGTC_1196 1588-0294 184 µM 1.2551253333911 0.13282776026431 no 435 0.104716632656146 530 6144269
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.25270989256693 0.133298349146939 no 436 0.105155652230757 489 279621
SGTC_980 1473-0395 201 µM 1.25132444708329 0.133568785978498 no 437 0.105408064825955 520 768876
SGTC_3000 9075062 71.4286 µM 1.25066765158401 0.133697123193765 no 438 0.105527878596458 553 17057871
SGTC_1745 st081495 74 µM 1.25046170836192 0.13373738175652 no 439 0.105565467390241 641 13842402 YBL026W LSM2
SGTC_3122 9126309 49.47 µM 1.25044824654961 0.133740013612836 no 440 0.105567924779723 554 17591206
SGTC_414 piperonyl butoxide 100 µM 1.24460729675865 0.134885311029061 no 441 0.106638068445087 572 5794 A potent inhibitor of cytochrome P450.
SGTC_856 0433-0016 11.3 µM 1.24263083500119 0.135274376123992 no 442 0.107001950903553 611 3911780
SGTC_2727 riluzole 51.77 µM 1.24249512843996 0.13530111805973 no 443 0.107026968389096 536 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1940 st075990 51.1 µM 1.23994653330273 0.135804009851698 no 444 0.107497585387985 644 1084979
SGTC_3120 9124077 49.47 µM 1.2374625359492 0.136295385515456 no 445 0.107957707318077 595 18774327 YGL155W CDC43
SGTC_2197 6588183 93.1375 µM 1.23606813020768 0.136571754453067 no 446 0.108216620001937 533 884136
SGTC_2663 amphotericin b 100 µM 1.23419465877403 0.136943676414645 no 447 0.108565188629444 549 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_201 4262-0159 12.803 µM 1.23407656999182 0.136967142593152 no 448 0.108587186658102 519 1341029
SGTC_643 k048-0106 28.4 µM 1.23356886097956 0.137068064006758 no 449 0.108681801154078 600 6763920
SGTC_2232 chlorophetanol 41.5365 µM 1.23322626992042 0.137136192295244 no 450 0.108745678462054 738 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2180 6301957 200 µM 1.23164037650696 0.137451867351754 no 451 0.109041725622776 584 845462
SGTC_3267 9137951 49.47 µM 1.23054027930011 0.137671134982804 no 452 0.109247426614901 529 16643986
SGTC_1049 3226-0134 66 µM 1.22890713340055 0.137997088100931 no 453 0.10955331331131 633 5702385
SGTC_615 k087-0205 167 µM 1.22855053796698 0.138068329526767 no 454 0.109620185027049 575 9642773
SGTC_320 4092-0846 5.34 µM 1.22664137320079 0.13845017327329 no 455 0.109978705856102 605 1359356
SGTC_2653 dihydrofissinolide 100 µM 1.22658334043671 0.138461791413592 no 456 0.109989616952384 571 6857746
SGTC_172 1112-0046 2.638 µM 1.22617500478287 0.138543558861536 no 457 0.110066412606382 534 2802135 YIL048W NEO1
SGTC_1919 st067113 52.3 µM 1.22580967250895 0.138616742949648 no 458 0.110135153216103 622 1268243
SGTC_3147 9097027 49.47 µM 1.22506393486557 0.138766212336626 no 459 0.110275566156074 632 25236841
SGTC_2111 5486399 200 µM 1.22393981301108 0.138991729256298 no 460 0.110487466589245 665 689674
SGTC_2852 9023854 51.95 µM 1.22322191676867 0.139135881270273 no 461 0.110622944886609 614 19798528
SGTC_1883 5-benzylidenerhodanine 20 µM 1.21496985775423 0.140800184337083 no 462 0.11218879393817 674 1273210
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.21430589882405 0.14093467849544 no 463 0.112315466966097 696 91467 include heat shock
SGTC_698 k064-0052 127 µM 1.21164521394213 0.14147451152262 no 464 0.112824109560933 560 5088751
SGTC_313 3474-0040 5.03 µM 1.21107996203531 0.141589377121563 no 465 0.112932380122906 659 1043375 YIL048W NEO1
SGTC_1931 st074438 57.1 µM 1.2103878674578 0.141730104610888 no 466 0.113065047595166 582 2787313
SGTC_2804 7954240 19.48 µM 1.20889822178327 0.142033323964961 no 467 0.113350974708614 649 828705
SGTC_331 k048-0133 24.5 µM 1.2054449349062 0.14273793301908 no 468 0.114015791737782 550 6813582
SGTC_1072 oxiconazole 14.9 nM 1.20454058817973 0.14292284581529 no 469 0.114190352089742 645 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1174 0739-0097 51.1 µM 1.20446380566498 0.142938553075335 no 470 0.114205181696476 632 728447
SGTC_1080 nisoldipine 24.4 µM 1.20377921587219 0.14307864993708 no 471 0.114337462503037 643 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2442 5158906 48.48 µM 1.20321600640222 0.143193976634547 no 472 0.114446371194916 634 1893835
SGTC_3258 9138477 49.47 µM 1.20109831102134 0.143628172488229 no 473 0.114856534064921 618 4970355
SGTC_1085 doxorubicin 7.67 µM 1.19937435967974 0.143982293564775 no 474 0.115191206456484 673 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_996 3970-0799 1.8 µM 1.19892672301165 0.144074339932503 no 475 0.115278219876054 802 6615648 YGL040C HEM2
SGTC_1432 4049-0298 68.4 µM 1.1972110250621 0.144427501900206 no 476 0.115612156842251 602 741646
SGTC_895 0964-0006 13.7 µM 1.19676367870095 0.144519680182556 no 477 0.115699339485155 616 6738897
SGTC_2907 7721985 69.9 µM 1.19357051336282 0.145178801365945 no 478 0.116323007018903 605 3267881
SGTC_3344 9148862 3.898 µM 1.19333686719871 0.145227109025996 no 479 0.116368734683369 627 4905352
SGTC_447 ml7 120 µM 1.19236525766896 0.145428110763874 no 480 0.116559028381867 633 4216 Selective myosin light chain kinase inhibitor.
SGTC_3113 9123498 49.47 µM 1.19192243685547 0.1455197813723 no 481 0.116645829820701 622 8897275
SGTC_2904 7225135 42.03 µM 1.19151363599327 0.145604443825263 no 482 0.116726003372189 645 4446116
SGTC_2287 7945887 168.79 µM 1.19027094119306 0.145862008620866 no 483 0.116969959108123 658 1245853
SGTC_256 clotrimazole 625 nM 1.19017276072558 0.145882370853853 no 484 0.116989248488978 620 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_3312 9133330 71.43 µM 1.18851206706503 0.146227081452095 no 485 0.117315864266432 674 17617324
SGTC_1819 st053448 58.6 µM 1.18607387737867 0.146734167493865 no 486 0.117796562826028 617 2857616
SGTC_573 3702-0553 84.7 µM 1.18475222128942 0.147009533374276 no 487 0.118057714219247 624 1222756
SGTC_811 0416-0114 265 µM 1.1827221853796 0.147433164079479 no 488 0.118459634359926 609 6612453
SGTC_1103 duloxetine 36.1 µM 1.17805564061137 0.148410083734639 no 489 0.119387212490925 713 60835 A selective serotonin reuptake inhibitor.
SGTC_2719 novobiocin 32.65 µM 1.17663658659005 0.148708012640483 no 490 0.119670294123399 557 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_745 0469-0705 296 µM 1.17608460640791 0.148824008223222 no 491 0.11978053430878 726 3486736
SGTC_2826 7992541 19.48 µM 1.17511110986827 0.149028730457525 no 492 0.119975133222984 613 2985066
SGTC_1391 3442-0225 151 µM 1.1685805095323 0.150406950741914 no 493 0.121286342342206 591 5227075
SGTC_985 1493-0307 8.71 µM 1.16728189596432 0.150682019616154 no 494 0.121548273662569 587 3278274
SGTC_601 0986-0029 62.9 µM 1.16616753916195 0.150918326611242 no 495 0.121773357031191 672 24747981
SGTC_3054 9094397 49.47 µM 1.16538801896554 0.151083775757035 no 496 0.121930982403838 675 2598354
SGTC_2786 7743617 45.45 µM 1.16365653742121 0.151451705406291 no 497 0.122281614722091 559 583674
SGTC_929 2805-0021 398 µM 1.16188345484883 0.151829091944448 no 498 0.122641404301194 626 3098024
SGTC_1193 1488-0126 41.5 µM 1.15497846368725 0.153304714561202 no 499 0.124049622912369 660 1384710
SGTC_2165 5727197 32.143 µM 1.15426550531578 0.153457615840877 no 500 0.124195666999677 628 1361712
SGTC_1875 nocodazole 6 µM 1.15410467684772 0.153492121123219 no 501 0.12422862810488 660 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_689 0833-0039 98 µM 1.15279355643511 0.153773609901551 no 502 0.124497564898915 687 5374726
SGTC_2496 diffractaic acid 79.83 µM 1.15133254723525 0.154087681092962 no 503 0.124797726069863 681 94870 An apoptosis inducer which activates caspases.
SGTC_1116 jasmonic acid 1.58368 µM 1.14947051193288 0.154488574973497 no 504 0.125181009633751 669 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1699 st031318 29.054 µM 1.14862607610563 0.154670607988539 no 505 0.125355099951076 659 5340658
SGTC_1264 0783-0040 158 µM 1.14826662417844 0.154748137171562 no 506 0.125429256427418 613 2855798
SGTC_2636 apigenin dimethyl ether 100 µM 1.14779254439603 0.154850429373552 no 507 0.125527107937996 676 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_377 3970-0964 33.1 µM 1.14767989716872 0.154874741833545 no 508 0.12555036649957 746 16481235
SGTC_1089 terbinafine 2.25 µM 1.14714772041582 0.15498963473097 no 509 0.125660287059527 651 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2291 7917025 104.35 µM 1.14709775359822 0.155000425075136 no 510 0.125670611101187 674 2964612
SGTC_40 0327-0103 19.753 µM 1.14531255921704 0.155386263633499 no 511 0.126039852624068 651 409036
SGTC_1330 1469-0054 61.8 µM 1.1421329017277 0.156075059449956 no 512 0.126699390575788 681 7102664
SGTC_3051 9093778 49.47 µM 1.14135460397766 0.156243964880946 no 513 0.126861193849739 601 17217378
SGTC_2926 9010726 65.15 µM 1.1401583905941 0.156503800644396 no 514 0.127110159546921 653 2994293
SGTC_2068 5226020 147 µM 1.13903085459447 0.15674897897368 no 515 0.12734514263132 701 1810509
SGTC_162 k030-0015 37.8 µM 1.13864400360966 0.156833156430951 no 516 0.127425833522026 693 1809920 YMR134W ERG29
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.1367073920912 0.157255003611158 no 517 0.127830314051677 912 16725076
SGTC_114 0364-0001 490.298 µM 1.13614047733846 0.157378634244251 no 518 0.127948888466364 675 4003655
SGTC_3123 9126162 49.47 µM 1.13576756258483 0.157459992914366 no 519 0.128026928000932 656 25239884
SGTC_76 0433-0009 400.328 µM 1.13557140366697 0.157502799923225 no 520 0.128067991269616 602 2841569
SGTC_2134 5324836 1.464 µM 1.13471480500978 0.157689821774278 no 521 0.128247416044656 598 699272
SGTC_2601 securinine 100 µM 1.13406177014943 0.15783249734483 no 522 0.12838431917407 651 442872 A GABA receptor antagonist.
SGTC_2279 7948423 32.93 µM 1.12798156562225 0.159164973351404 no 523 0.129663852247524 616 1247112
SGTC_2942 9052777 62.25 µM 1.12707856191497 0.159363493104646 no 524 0.129854633235933 743 6469503
SGTC_83 0170-0301 39.027 µM 1.12543620949801 0.159724969476118 no 525 0.130202117208272 584 3089716
SGTC_2038 4100038 30.985 µM 1.1253522976283 0.159743452596886 no 526 0.130219888288536 697 3596803
SGTC_1182 1222-0449 220 µM 1.12505030816982 0.159809982866844 no 527 0.130283858312167 659 658318
SGTC_2284 7945075 39.21 µM 1.12333126793497 0.160189043996111 no 528 0.130648414411186 759 1245402
SGTC_177 1327-0068 8.361 µM 1.12313392310113 0.160232597575819 no 529 0.130690310327499 698 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.12294339669247 0.160274653686881 no 530 0.130730767516952 731 676296 Flavone; oxidizing agent.
SGTC_2349 9023730 187.07 µM 1.11952342073063 0.161030793754942 no 531 0.131458452482601 673 4126287
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.11621905914804 0.161763579797101 no 532 0.132164189091247 671 6708514
SGTC_2833 9001315 45.46 µM 1.11516186873557 0.161998483930389 no 533 0.132390531511486 692 2989378
SGTC_27 0485-0001 32.618 µM 1.11402773313066 0.162250731938493 no 534 0.132633644608004 612 2054479
SGTC_3048 9093155 49.47 µM 1.1122465805094 0.162647401671116 no 535 0.133016072572421 618 25236002
SGTC_1033 k072-0102 21.3 µM 1.11125620132588 0.162868235717887 no 536 0.133229043098792 712 5965931
SGTC_1998 st075797 76.8 µM 1.11102446343402 0.162919936602824 no 537 0.133278909726955 774 24208315
SGTC_3036 9090181 49.47 µM 1.11025160275367 0.16309243948659 no 538 0.133445310945651 697 25236586
SGTC_2892 9047358 58.44 µM 1.10983006238148 0.163186577520057 no 539 0.133536131142995 641 6466771
SGTC_213 1246-0773 967 nM 1.10911396451126 0.163346576805164 no 540 0.133690510702978 730 6251622
SGTC_1728 st035614 33.7865 µM 1.10910434015949 0.163348727888559 no 541 0.133692586398814 766 15945546
SGTC_2713 st079149 53.4 µM 1.10897840643657 0.163376876304895 no 542 0.133719748722189 729 3103253
SGTC_2485 5633444 17.78 µM 1.10652086326813 0.163926811351683 no 543 0.134250569430481 676 5724239
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.1064130076663 0.163950974148338 no 544 0.134273898967469 645 2374 Ca(2+)-ATPase inhibitor.
SGTC_2772 vinpocetine 57.06 µM 1.10514852731561 0.164234426933138 no 545 0.13454761808321 689 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_585 0kpi-0023 191 µM 1.10421843281669 0.164443124693718 no 546 0.13474919779031 654 64601
SGTC_3241 9133421 49.47 µM 1.1039378137021 0.164506124705303 no 547 0.134810057142621 674 17018221
SGTC_409 arachidonic acid 100 µM 1.10331046384349 0.164647023599351 no 548 0.134946182025894 705 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_484 loperamide 105 µM 1.10200255783893 0.164941022554389 no 549 0.135230279801499 595 3955 An opioid-receptor agonist.
SGTC_197 4544-0043 41.561 µM 1.1013539527383 0.165086945916919 no 550 0.13537131902596 726 896523
SGTC_3005 9076496 71.4286 µM 1.10126117703965 0.165107825450539 no 551 0.135391501347059 670 21368410
SGTC_339 3091-4833 71.4 µM 1.1005788447747 0.165261439511532 no 552 0.135539998497175 707 3240077
SGTC_1652 st011932 78 µM 1.09968119389212 0.165463669271744 no 553 0.135735525729336 675 1551076
SGTC_2822 7994718 71.43 µM 1.09967783194386 0.165464426978327 no 554 0.13573625839529 599 1018011
SGTC_374 0880-0231 82.3 µM 1.09720250890855 0.166022917614776 no 555 0.136276438332621 708 6833587
SGTC_2849 9019321 12.99 µM 1.09526661374775 0.166460548557562 no 556 0.136699924777184 668 16489627
SGTC_2694 st077685 81.9 µM 1.09513820709248 0.166489602644816 no 557 0.136728046139977 683 2838096
SGTC_2596 sinensetin 100 µM 1.09265762818106 0.167051516246158 no 558 0.137272075074576 667 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2752 diclazuril 33.15 µM 1.09168132940813 0.16727300749193 no 559 0.137486597235769 889 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_171 k064-0041 9.68 µM 1.0916484257808 0.167280475577723 no 560 0.137493831135477 598 53325
SGTC_451 chloral hydrate 100 µM 1.09033587893095 0.16757855758296 no 561 0.137782607981615 770 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2583 asiatic acid 100 µM 1.08970801167363 0.167721268394083 no 562 0.13792089291894 695 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1172 0370-0043 85 µM 1.08840219155875 0.16801832476706 no 563 0.138208797046911 706 376585
SGTC_1358 1509-0022 2.48 µM 1.08781786174781 0.168151361470073 no 564 0.138337761308309 719 3258434
SGTC_2992 9074591 71.4286 µM 1.08463096782473 0.168878126753343 no 565 0.139042566776355 695 17741321
SGTC_1185 1319-0113 81.3 µM 1.08365664575451 0.169100721309873 no 566 0.139258532453596 666 4672763
SGTC_1559 coumarin 343 70.1 µM 1.08348533245593 0.169139879178386 no 567 0.139296528893112 680 108770 A hepatotoxic, DNA x-linker.
SGTC_2131 toluylene red 5.2905 µM 1.08156748931569 0.169578646803049 no 568 0.139722378499426 698 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_3227 9130768 49.47 µM 1.08100392847486 0.169707717963454 no 569 0.139847683074486 750 17720899
SGTC_1516 st013856 110 µM 1.07857543594825 0.170264631066636 no 570 0.140388518275413 698 5281404 A mutagen and neurotoxin.
SGTC_3222 9128301 49.47 µM 1.07675037428826 0.170683932322178 no 571 0.14079590050037 731 4911358
SGTC_1985 st071382 65.5 µM 1.07489483940356 0.17111091171013 no 572 0.141210906355841 733 6123237
SGTC_877 0771-0151 33.1 µM 1.07404378489413 0.171306977212683 no 573 0.141401528944951 745 6166523
SGTC_1425 4048-4433 7.33 µM 1.07403243422341 0.171309593144572 no 574 0.141404072491465 784 23734946
SGTC_1696 st025591 34.7925 µM 1.07148807616549 0.171896622933094 no 575 0.141975014638307 754 2787147
SGTC_2549 cedrol 20.94 µM 1.06967311439937 0.172316151661416 no 576 0.142383236074251 671 6708665 A sedative which affects the nervous system.
SGTC_927 2425-1185 123 µM 1.06737544563307 0.172848194288776 no 577 0.142901165887548 722 730375
SGTC_560 2332-1943 155 µM 1.06671636419347 0.173001002610274 no 578 0.143049967669105 740 21177716
SGTC_890 0929-0006 47.2 µM 1.06573891785265 0.17322778238866 no 579 0.143270839852174 701 1378169
SGTC_1066 ketoconazole 628 nM 1.06510823383163 0.173374209404027 no 580 0.14341347682475 781 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2883 9059145 45.46 µM 1.06361974386962 0.173720107054049 no 581 0.143750497259385 693 16476510
SGTC_711 k292-0785 179 µM 1.06269241728723 0.173935822460581 no 582 0.143960730345583 737 4146315
SGTC_1581 himbacine 57.9 µM 1.06136625766304 0.174244610533177 no 583 0.144261742565925 750 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_150 3970-0969 77.2 µM 1.06092114926225 0.17434832930816 no 584 0.144362868472266 798 6615640
SGTC_1618 st003135 44.5 µM 1.06089051860823 0.174355468278919 no 585 0.14436982932611 727 1270615
SGTC_2880 9042983 58.44 µM 1.06071565218278 0.174396227292137 no 586 0.144409572268415 727 6464714
SGTC_704 1310-0270 142 µM 1.06065469586405 0.174410436813301 no 587 0.144423427909786 747 5718033
SGTC_3057 9095946 49.47 µM 1.05481437066441 0.175775284530807 no 588 0.145755115422285 769 24540043
SGTC_1055 3448-0672 86 µM 1.05418299908015 0.175923236324895 no 589 0.145899571037789 735 748378
SGTC_2497 7-hydroxyflavone 100 µM 1.05310922187951 0.176175039825559 no 590 0.146145468398106 693 5281894
SGTC_2356 9061756 188.97 µM 1.05264361890075 0.176284295783292 no 591 0.146252178985964 736 20104043
SGTC_3131 9127911 49.47 µM 1.04800201652874 0.177375813158803 no 592 0.147318838903842 717 45595681
SGTC_244 nsc-207895 1.295 µM 1.04783657708771 0.177414796424908 no 593 0.147356953574063 633 42640
SGTC_2622 2-methoxyxanthone 59.94 µM 1.04652572385057 0.177723870070497 no 594 0.147659187353798 811 71034 A hepatoprotective.
SGTC_2718 lomofungin 53.02 µM 1.0458175852343 0.177890976592378 no 595 0.147822630265198 734 5351222 A RNA synthesis inhibitor.
SGTC_1530 rhein 70.4 µM 1.04543911091599 0.177980329568337 no 596 0.147910034205531 804 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_3088 9117578 49.47 µM 1.04522804456609 0.178030171940811 no 597 0.147958792379821 753 678341
SGTC_3276 9139060 49.47 µM 1.04093701478205 0.179045387011713 no 598 0.148952390658218 713 4870619
SGTC_3204 9114183 49.47 µM 1.03899193588584 0.179506770744143 no 599 0.149404243359005 727 17027248
SGTC_1853 st056710 91.2 µM 1.03842759034639 0.179640776450375 no 600 0.149535515056801 802 269167
SGTC_1030 k029-0042 36.7 µM 1.03629964546127 0.180146629167649 no 601 0.150031185756111 800 6080581
SGTC_412 gemfibrozil 100 µM 1.03609514222438 0.180195290502666 no 602 0.150078879143118 716 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1513 0337-0559 19 µM 1.03500798961825 0.180454115835028 no 603 0.150332589989075 679 775073
SGTC_2624 nerol 100 µM 1.03491085414763 0.180477252838266 no 604 0.150355272576876 753 637566 A natural product oil.
SGTC_2423 st077119 87.2 µM 1.03406697333005 0.180678337765616 no 605 0.150552427352981 753 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.03270607736834 0.181002915947398 no 606 0.150870734304588 751 6710655
SGTC_2159 5658611 73.75 µM 1.03227615670406 0.181105529340628 no 607 0.150971383705905 785 793844
SGTC_1778 st046819 58.9 µM 1.03207718172546 0.181153032989623 no 608 0.151017981174134 814 671715
SGTC_2271 7849410 118.62 µM 1.03083620378306 0.181449482437836 no 609 0.151308818771688 778 972430
SGTC_2677 mitomycin C 100 µM 1.02917550059817 0.181846672256104 no 610 0.151698606320101 719 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2310 7668677 200 µM 1.02803258130325 0.182120339548347 no 611 0.151967250938941 745 2197143
SGTC_1205 4161-2785 76 µM 1.02458691082153 0.182946948095044 no 612 0.152779071583631 697 3498106
SGTC_2301 7769476 200 µM 1.02257626234365 0.183430378064823 no 613 0.15325411890237 736 977820
SGTC_3250 9135583 49.47 µM 1.02099021089162 0.183812281421459 no 614 0.153629538310672 752 7699353
SGTC_2322 7413319 38.22 µM 1.02044548730699 0.183943558914056 no 615 0.153758615098973 865 1840400
SGTC_29 0299-0004 12.984 µM 1.01757206524518 0.184637014804508 no 616 0.154440684211981 674 16871 A napthoquinone isolated from Swertia calycina.
SGTC_3156 9099931 49.47 µM 1.0138947021114 0.185526857303148 no 617 0.155316499811457 837 18111053
SGTC_2386 9075165 157.42 µM 1.0138052072051 0.185548546260789 no 618 0.155337855055078 782 16452277
SGTC_1640 st009078 66.4 µM 1.0130439634976 0.185733096153373 no 619 0.155519581103626 715 690618
SGTC_2110 5483698 200 µM 1.01116233598942 0.18618975137469 no 620 0.155969369595715 770 2848765 YHR062C RPP1
SGTC_1839 st053978 48 µM 1.00845760958199 0.186847383551392 no 621 0.156617414133489 792 3788398
SGTC_99 0109-0120 622.8 µM 1.0075708429325 0.187063306159542 no 622 0.1568302661139 755 759414
SGTC_1453 4237-0541 195 µM 1.00747481063843 0.187086698733131 no 623 0.156853328313011 823 739892
SGTC_963 1269-2853 151 µM 1.0063577382754 0.187358940094294 no 624 0.157121757691237 749 3668223
SGTC_1933 st074711 15.9 µM 1.00430089595226 0.187860852705581 no 625 0.157616800966573 808 17250958
SGTC_1991 st073000 8.92 µM 1.00321960709189 0.188125042496464 no 626 0.157877457387116 842 4301969 YIL048W NEO1
SGTC_2280 7785178 200 µM 1.00308720721284 0.188157407323123 no 627 0.157909393256738 770 2954328
SGTC_2792 7535235 81.82 µM 1.00197239915046 0.188430055680917 no 628 0.158178461756095 718 1281891
SGTC_2979 9012552 45.46 µM 1.00141051494857 0.188567567884224 no 629 0.158314191314048 751 17100905
SGTC_1974 st069448 26.9 µM 0.997423109135718 0.189545198537905 no 630 0.159279589467154 792 6323587 YNR016C ACC1
SGTC_2059 5238311 157 µM 0.997418398007362 0.189546355451945 no 631 0.159280732362514 760 703021
SGTC_438 sphingosine 6.67 µM 0.994498347612876 0.190264269340218 no 632 0.159990154733728 701 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_989 1501-0895 10.3 µM 0.991723706887343 0.190947978759387 no 633 0.160666161615205 825 2830112
SGTC_397 arbidol 50 µM 0.989930771616197 0.19139058305031 no 634 0.161103978839613 868 131410 A RNA synthesis inhibitor.
SGTC_3022 9087993 49.47 µM 0.989758055234814 0.191433253017899 no 635 0.161146195558326 813 17173644
SGTC_2250 alverine citrate 130 µM 0.988685815935874 0.191698282534504 no 636 0.161408442343924 854 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1164 k060-0068 93.7 µM 0.988473034441915 0.191750903263519 no 637 0.161460517220447 851 5963676
SGTC_2030 5175110 200 µM 0.988256950914831 0.191804349633922 no 638 0.161513411427204 810 2831986
SGTC_3025 9087895 49.47 µM 0.987327958168801 0.192034231745126 no 639 0.161740944460629 870 17173641
SGTC_1363 1636-0063 10.4 µM 0.983413195781789 0.193004802672069 no 640 0.16270205917811 856 6072185
SGTC_2414 st077232 92.9 µM 0.982488738606949 0.193234436002952 no 641 0.162929564104105 753 729801
SGTC_1723 st034307 2.5525 µM 0.98230772853188 0.193279418061229 no 642 0.162974134105362 812 867466
SGTC_538 2922-0838 53.3 µM 0.976649327569147 0.194688784044177 no 643 0.164371394776006 910 777039
SGTC_3295 9122362 53.5725 µM 0.973787844296639 0.195403882141843 no 644 0.165080944942583 773 4730473
SGTC_3159 9100096 49.47 µM 0.973669343448136 0.195433530423633 no 645 0.165110371803693 807 25236875
SGTC_3170 9103054 49.47 µM 0.972904392502666 0.195624982820192 no 646 0.165300410840897 771 16432970
SGTC_1300 1094-0077 113 µM 0.972513025554271 0.19572297839982 no 647 0.165397694006318 779 5532636
SGTC_79 0052-0007 94.094 µM 0.970631359465953 0.1961945504845 no 648 0.165865942009297 832 2801472
SGTC_1437 4092-1038 11.6 µM 0.969433457934609 0.196495120116138 no 649 0.166164482809441 876 3977136
SGTC_215 1287-0124 461.5 µM 0.967027693556104 0.197099601107969 no 650 0.166765094841505 825 5560863
SGTC_18 0111-0177 500 nM 0.966974012696131 0.197113101976014 no 651 0.166778512513648 925 721752
SGTC_962 1254-0300 21.5 µM 0.966476289855083 0.197238307139282 no 652 0.166902952813929 833 7340576
SGTC_2211 7117706 200 µM 0.965870310958546 0.197390809693067 no 653 0.16705454003923 804 822771
SGTC_1473 k844-0725 134 µM 0.965239609427378 0.197549609732371 no 654 0.167212405951547 912 54682906
SGTC_628 1636-0253 16 µM 0.964688906001749 0.197688330734766 no 655 0.167350326788231 849 4456143
SGTC_1051 3253-3903 78 µM 0.962878890510415 0.198144684288173 no 656 0.167804152141131 876 5509239
SGTC_3209 9113616 49.47 µM 0.962133373578039 0.198332833930592 no 657 0.167991305856162 878 16649353
SGTC_1179 1021-1431 9.29 µM 0.961427397120574 0.198511103912079 no 658 0.168168657172063 874 2840958
SGTC_98 0074-0023 107.663 µM 0.959344616245819 0.199037601291923 no 659 0.168692582961259 869 3563821
SGTC_1842 st055362 61.2 µM 0.957448531924068 0.199517635316515 no 660 0.169170456251085 891 676032
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.956938858624077 0.19964678867248 no 661 0.169299058141667 873 688798
SGTC_878 0828-0289 13.7 µM 0.956199877515514 0.19983413891353 no 662 0.169485630910427 850 745350 YLR208W SEC13
SGTC_1829 berberine 14.4 µM 0.947634936521949 0.202013272209024 no 663 0.17165766706466 853 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2458 5808907 16.39 µM 0.947103800590682 0.202148873058391 no 664 0.171792944139983 931 2731747
SGTC_1912 st060209 90.8 µM 0.944528311663673 0.202807176259531 no 665 0.172449870614495 799 688787
SGTC_599 1935-0052 86.5 µM 0.944523926582876 0.20280829819127 no 666 0.172450990475667 880 9557311
SGTC_2195 6536160 144.242 µM 0.943378653288787 0.203101445599155 no 667 0.172743628962608 779 3834386
SGTC_2975 9084847 53.72 µM 0.941773105723408 0.203512831762405 no 668 0.173154408617034 862 27211724
SGTC_311 1315-0136 58 µM 0.941670533475464 0.203539130519235 no 669 0.17318067287185 863 6759207
SGTC_2016 5121758 140 µM 0.940383970348891 0.203869167804566 no 670 0.173510320738328 921 2795203
SGTC_3341 9147222 25.867 µM 0.936791599732208 0.204792392426404 no 671 0.174432883575831 813 1939759
SGTC_1053 3366-3204 134 µM 0.935244266640865 0.205190815662345 no 672 0.1748312151704 855 3632071 YPR165W RHO1
SGTC_924 2046-0044 21.3 µM 0.935093628186516 0.205229628187178 no 673 0.174870025002156 895 3623589
SGTC_9 0092-0002 10.449 µM 0.932517781850428 0.205893978745348 no 674 0.175534500707946 868 759368
SGTC_907 3448-6986 75.5 µM 0.931291578252153 0.206210683293837 no 675 0.175851378587616 933 590582
SGTC_616 4092-0450 108 µM 0.930284023136544 0.206471131193685 no 676 0.176112023891426 904 787165
SGTC_3072 9116419 49.47 µM 0.930057213121901 0.206529787296555 no 677 0.176170731275024 805 17170162
SGTC_1423 4048-0112 5.59 µM 0.929424712567815 0.206693412534205 no 678 0.176334512809375 900 X1423
SGTC_34 0469-0683 81.75 µM 0.929357417446667 0.206710826016314 no 679 0.176351944072596 888 3690923
SGTC_2882 9058044 58.44 µM 0.928899556172369 0.20682932659594 no 680 0.176470571513907 855 18076804
SGTC_2897 9048598 12.99 µM 0.92377842259878 0.20815748200811 no 681 0.177800845819463 841 6467404
SGTC_1019 4262-0212 3.4 µM 0.92244546844851 0.208504004654154 no 682 0.17814813109002 984 4677213
SGTC_420 mitomycin C 81.9 mM 0.917879209743284 0.209693651947139 no 683 0.179341053584404 877 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1590 st077108 57.8 µM 0.917756402934261 0.209725701821181 no 684 0.179373205729377 883 5489485
SGTC_582 0987-0078 156 µM 0.916435312080111 0.210070659563918 no 685 0.179719310705509 1006 1625765
SGTC_3185 9108267 49.47 µM 0.91626865988508 0.210114198756248 no 686 0.179763000736909 890 4910486
SGTC_2162 5663267 200 µM 0.916230229230537 0.210124239818129 no 687 0.17977307677744 942 6456493
SGTC_1709 st033179 39.1045 µM 0.915687684721841 0.210266024519019 no 688 0.179915363071767 901 573381
SGTC_448 monastrol 171 µM 0.914058719250756 0.2106920641355 no 689 0.180342996081091 915 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_709 3807-1509 243 µM 0.913434023866866 0.210855581209908 no 690 0.180507159008337 896 1886677 YPL242C IQG1
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.912036861533084 0.211221564529393 no 691 0.180874656691109 961 65057 A dermal irritant. YDR527W RBA50
SGTC_1297 1068-0111 14.1 µM 0.911390017653165 0.211391129701474 no 692 0.181044955694035 862 767057
SGTC_3325 9138760 55.175 µM 0.906529625237866 0.212667792298637 no 693 0.182327795855198 871 43844959
SGTC_3066 9117245 49.47 µM 0.906489783420514 0.212678275981987 no 694 0.182338335023094 948 17176980
SGTC_755 1995-0008 37.3 µM 0.90592344816086 0.212827329913662 no 695 0.182488186175412 924 689533
SGTC_17 0960-0276 49.807 µM 0.90512683959738 0.213037092712071 no 696 0.182699097332776 959 6821114
SGTC_2732 terfenadine 20 µM 0.904496893943677 0.213203055240117 no 697 0.182865990311058 885 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1263 0774-1208 64.8 µM 0.903875314581529 0.213366887505635 no 698 0.183030760021647 975 906585
SGTC_1588 farnesol 29.9 µM 0.903856161827779 0.213371936842119 no 699 0.183035838549032 881 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2202 7226349 200 µM 0.903650422741579 0.213426181261781 no 700 0.183090397689197 875 844334
SGTC_3154 9100113 49.47 µM 0.902350091159471 0.213769207859388 no 701 0.183435462168415 903 25237525
SGTC_1877 wortmannin 25 µM 0.902096044140468 0.213836262767245 no 702 0.183502925053662 944 312145 A covalent inhibitor of PI 3-kinase.
SGTC_681 1642-0006 26.6 µM 0.900220880412806 0.214331585026934 no 703 0.184001358168825 916 4446530
SGTC_2690 usnic acid 100 µM 0.899440041385257 0.214538039363028 no 704 0.184209159617615 958 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_603 3794-0023 45.9 µM 0.899410167949487 0.214545940213908 no 705 0.184217112610784 904 3802260
SGTC_2943 9068529 45.32 µM 0.896603878031529 0.215288894654352 no 706 0.18496516399617 1005 3270634
SGTC_3313 9133968 57.047 µM 0.894927152633124 0.215733512844405 no 707 0.185413015412354 960 1494643
SGTC_2118 5526350 200 µM 0.892869317250649 0.216279917022508 no 708 0.185963580029474 938 743594
SGTC_1283 0922-0125 16.4 µM 0.892843860818118 0.216286681323089 no 709 0.185970397124865 971 3360884
SGTC_2072 5231554 129 µM 0.892135490699217 0.216474959029708 no 710 0.186160156965461 1019 789545
SGTC_1986 st071812 45 µM 0.891288803111219 0.216700124516215 no 711 0.186387126991636 885 11838594
SGTC_87 0100-0052 35.5 µM 0.89126540338081 0.21670634929121 no 712 0.1863934021488 1084 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1806 st050005 60.3 µM 0.890858256988011 0.216814674556482 no 713 0.186502608440833 892 5194765
SGTC_2895 9054447 58.44 µM 0.886267258104837 0.218038319637226 no 714 0.187736764047478 917 2697450
SGTC_3173 9105693 49.47 µM 0.88393989053775 0.218660153596705 no 715 0.188364330996884 954 17096658
SGTC_1288 0973-0013 65.5 µM 0.883198031042741 0.218858580481354 no 716 0.188564642620685 955 4315430
SGTC_2553 4-methylesculetin 85.09 µM 0.881384908459624 0.219343976366565 no 717 0.189054761581851 968 5319502
SGTC_3109 9122853 49.47 µM 0.88127165690521 0.219374315756297 no 718 0.189085401485049 1007 1234709
SGTC_713 1488-1073 324 µM 0.880396367213203 0.219608881765758 no 719 0.189322311903719 951 3312542
SGTC_3026 9090633 49.47 µM 0.880350988928796 0.219621046469173 no 720 0.189334599204028 953 25236842
SGTC_2281 7943571 200 µM 0.879969222857581 0.219723403055149 no 721 0.189437991308639 1026 1244024
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.879100593846095 0.219956396127462 no 722 0.189673367900962 895 5282362
SGTC_1733 st037357 54.9 µM 0.87717849262063 0.220472466535251 no 723 0.190194848023485 906 1272339 YGL099W LSG1
SGTC_2409 alverine citrate 63.97 µM 0.873158473529952 0.221554053164621 no 724 0.19128835290346 924 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_343 4130-2827 29.8 µM 0.873147789790647 0.221556931660839 no 725 0.191291264164008 926 1118244
SGTC_1661 st013063 9.66 µM 0.872271043610499 0.221793224285109 no 726 0.191530265257773 1008 721395
SGTC_2348 9022543 33.42 µM 0.872020883174407 0.221860671629351 no 727 0.1915984925478 956 3162678 YDL140C RPO21
SGTC_1327 1436-0082 2.18 µM 0.86921806976404 0.222617156411897 no 728 0.192363932854287 938 15992205
SGTC_2809 7964133 12.99 µM 0.868797093380797 0.222730905636246 no 729 0.192479061609415 920 1253665
SGTC_3279 9140807 49.47 µM 0.868071695592973 0.222926988235325 no 730 0.192677542433209 957 45595718
SGTC_2417 cerulenin 830 nM 0.867982916878078 0.222950992801213 no 731 0.192701842344231 938 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_419 nsc-638432 893 µM 0.867844982288254 0.222988291372685 no 732 0.192739600584633 948 368090
SGTC_987 1497-1013 404 µM 0.866059670176597 0.223471374045867 no 733 0.193228720065717 958 1676435
SGTC_3037 9091026 49.47 µM 0.865508603548915 0.223620605801059 no 734 0.193379847905699 1022 25236398 YIL048W NEO1
SGTC_1029 k015-0030 64.7 µM 0.863785943013899 0.224087476678188 no 735 0.193852745649847 922 2208316
SGTC_2368 9071271 200 µM 0.861841154164211 0.224615212900643 no 736 0.194387467393512 924 27209959
SGTC_433 pimozide 108 µM 0.861829040824615 0.224618502173836 no 737 0.194390800780466 859 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1074 carmofur 3.8 µM 0.860358203246036 0.225018098503215 no 738 0.194795809108277 1028 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_677 0929-0063 136 µM 0.860318207191044 0.225028970232416 no 739 0.194806829544385 910 1539583
SGTC_1688 st021091 57.6 µM 0.859887910338939 0.225145952365165 no 740 0.194925416696741 983 3656366
SGTC_504 lovastatin 124 µM 0.859633279159446 0.225215193585156 no 741 0.194995612144992 913 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2623 humulene 100 µM 0.858094232225339 0.225633959451794 no 742 0.195420215985976 837 6187145 An anti-inflammatory.
SGTC_860 0443-0016 25.1 µM 0.857704777009463 0.225739997797337 no 743 0.195527750791267 1036 5337942
SGTC_2478 5763493 32.33 µM 0.856939049223487 0.225948567381254 no 744 0.195739285219136 969 1365576 YLR208W SEC13
SGTC_3273 9137859 49.47 µM 0.854745859439381 0.226546552817353 no 745 0.196345928259016 978 2377234
SGTC_3309 9129340 25.759 µM 0.854336224799285 0.226658340926533 no 746 0.196459360641377 1008 17158987
SGTC_3121 9125696 49.47 µM 0.852518995819743 0.227154632683424 no 747 0.196963050222331 990 1235365
SGTC_3077 9117319 49.47 µM 0.851892423007018 0.227325893874059 no 748 0.197136901318858 962 17154678
SGTC_337 1315-0038 354 µM 0.851563759171939 0.227415756664341 no 749 0.197228130657912 950 1626437
SGTC_1623 st003709 20.3 µM 0.849403770801118 0.228006835210724 no 750 0.197828327824696 974 16192618
SGTC_2448 5185112 27.17 µM 0.848422657023686 0.228275601092642 no 751 0.19810131452226 887 5718189
SGTC_1148 3909-7663 27.7 µM 0.84668984275887 0.228750722197439 no 752 0.198584010853259 1008 4084526
SGTC_1888 azatryptophan 97.5 µM 0.845935890805118 0.228957621820846 no 753 0.198794254560811 889 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_3078 9116413 49.47 µM 0.844760655266534 0.229280339468877 no 754 0.199122243033612 973 17177322
SGTC_830 4076-0286 57.8 µM 0.844724618341934 0.22929023917445 no 755 0.199132305481881 1067 6866659
SGTC_128 0906-2981 13.371 µM 0.84425174592101 0.229420164185436 no 756 0.199264372162091 906 6740226
SGTC_2767 sibutramine 71.45 µM 0.843785217021813 0.229548386694869 no 757 0.199394718863316 980 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_445 e6 berbamine 66 µM 0.843150891883414 0.229722791329952 no 758 0.199572029630896 1045 6610268 A calcium/calmodulin antagonist.
SGTC_2270 7924575 90.91 µM 0.842505478420251 0.229900320787461 no 759 0.199752537238903 997 1262135
SGTC_3352 9151559 45.5865 µM 0.83872869056445 0.230940714136144 no 760 0.200810787265805 952 17159339
SGTC_2185 6113692 200 µM 0.838663436087561 0.230958712885175 no 761 0.20082910098714 916 874150
SGTC_3075 9116269 49.47 µM 0.837542747651348 0.231267947810307 no 762 0.201143779494334 979 17015205 YNL244C SUI1
SGTC_3097 9117246 49.47 µM 0.836565798035876 0.231537708776104 no 763 0.20141833861322 1032 16423892
SGTC_983 1491-0821 12.2 µM 0.836498460721264 0.231556308803578 no 764 0.201437271169599 998 46495113
SGTC_2480 5767542 37.17 µM 0.835520439030125 0.2318265534974 no 765 0.201712371922161 1008 2867358
SGTC_1775 st081588 35.1725 µM 0.834879969662643 0.232003621667657 no 766 0.201892646850484 1061 1426443 YGL099W LSG1
SGTC_2818 7996756 12.99 µM 0.834312070514557 0.232160689587397 no 767 0.202052575863976 959 2241621
SGTC_1958 st076513 41.9 µM 0.832748274452558 0.232593505536012 no 768 0.202493356214034 1006 732122 YGL099W LSG1
SGTC_209 4077-0173 175.592 µM 0.8316985671688 0.232884287221273 no 769 0.20278955481203 897 15993494
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.830408353872228 0.233241968486146 no 770 0.203153972005812 1026 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_341 1486-1430 230 µM 0.830036224378839 0.233345189252297 no 771 0.203259151550001 1005 2054753 YPL210C SRP72
SGTC_2221 6807166 181.081 µM 0.82916719464065 0.233586338204811 no 772 0.203504902667082 963 674925
SGTC_2824 7998404 51.95 µM 0.82899890143655 0.233633054219464 no 773 0.203552514429334 945 837851
SGTC_2552 juarezic acid 87.02 µM 0.828753575297945 0.233701162858143 no 774 0.203621931447782 1138 1549512
SGTC_301 4119-0100 24.5 µM 0.828294712275286 0.233828584189755 no 775 0.203751808347367 1006 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1218 1348-1416 30.7 µM 0.82743291201978 0.234068000886073 no 776 0.203995866306127 1027 6787668
SGTC_147 4466-0538 29.23 µM 0.826694188335922 0.234273333704462 no 777 0.204205208111216 1117 6742687 YHR072W ERG7
SGTC_1032 k061-1018 98.7 µM 0.82119906830449 0.235803861537094 no 778 0.205766443573755 1090 4005393
SGTC_1349 flufenamic acid 69 µM 0.821039290863066 0.235848445860409 no 779 0.205811944149004 960 3371 A non-steroidal anti-inflammatory.
SGTC_3038 9091290 49.47 µM 0.820348500706356 0.236041257526273 no 780 0.206008732407764 999 25236843
SGTC_2294 7971431 200 µM 0.819777746357953 0.236200630593226 no 781 0.206171409727171 926 5741572
SGTC_2388 9080168 200 µM 0.818713316541321 0.236498012079096 no 782 0.206474998596391 941 15943073
SGTC_476 mead acid 10 µM 0.814290432371418 0.237735886079811 no 783 0.207739294728513 1010 5312531 An omega 9 fatty acid.
SGTC_1355 1499-0035 1.68 µM 0.813703205689611 0.23790050556657 no 784 0.207907498633999 998 1548538
SGTC_1993 st073995 70.8 µM 0.812944313401592 0.238113341273691 no 785 0.208124993129911 1026 3098394
SGTC_2655 perillic acid 100 µM 0.812261868042216 0.238304826075195 no 786 0.208320692965251 1008 5702197 An apoptosis inducer.
SGTC_153 4077-0274 519.67 µM 0.811963102664497 0.238388682077097 no 787 0.208406401867454 991 3121976
SGTC_2077 5212015 200 µM 0.810402518578479 0.238826961701463 no 788 0.208854435409499 975 780900
SGTC_2838 9002687 71.43 µM 0.810146446289362 0.238898919965035 no 789 0.20892800625905 953 6457060
SGTC_3193 9111931 49.47 µM 0.809270092520428 0.239145271746817 no 790 0.209179902578031 1040 17087244
SGTC_2149 5554786 194.827 µM 0.807682274790213 0.239591976581256 no 791 0.209636755002519 1057 745063 YPR165W RHO1
SGTC_2628 lathosterol 100 µM 0.806577800297232 0.239902969629159 no 792 0.209954883992433 1063 6710616
SGTC_1287 0971-0001 34.6 µM 0.805784700427165 0.240126422929649 no 793 0.2101835006249 1041 4665869
SGTC_1042 0350-0096 82 µM 0.804208128161094 0.240570953741977 no 794 0.210638392673204 1001 3122515
SGTC_2147 5545932 89.7195 µM 0.802714819352597 0.240992420399431 no 795 0.211069792735207 1007 797404
SGTC_1458 k015-0034 6.33 µM 0.801858020801442 0.241234421633777 no 796 0.21131754579764 1007 3598957
SGTC_2729 fluphenazine 10.66 µM 0.801136282429631 0.241438377802314 no 797 0.211526376800125 1039 3372 An atypical antipsychotic.
SGTC_2575 plumbagin 510 nM 0.800890187576522 0.24150794319652 no 798 0.211597610598917 987 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_317 4495-0002 170 µM 0.799538972088217 0.241890094848977 no 799 0.211988979102521 981 15991618
SGTC_1690 st023502 41.2 µM 0.796673246632964 0.242701665781035 no 800 0.212820412729136 1026 24207482
SGTC_1722 st034304 3.6505 µM 0.794709506109271 0.243258645369114 no 801 0.213391250690293 1066 4036148 YLR033W RSC58
SGTC_1381 2324-0066 62.1 µM 0.794232067052077 0.243394166685224 no 802 0.213530171779835 997 10885928
SGTC_2018 5133068 143 µM 0.793910345112543 0.243485510621386 no 803 0.213623813363588 989 785362
SGTC_2264 7948757 110.76 µM 0.793060531157512 0.243726880535279 no 804 0.213871278407293 1077 2971411
SGTC_658 3253-0951 102 µM 0.792842458419153 0.243788839851149 no 805 0.213934807890388 1091 1184878
SGTC_2790 5423970 71.43 µM 0.789913705072672 0.244621787051841 no 806 0.214789083467486 1064 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_721 1187-1332 279 µM 0.789795369380234 0.244655474300914 no 807 0.214823641907633 943 25730
SGTC_1852 st056254 31.4 µM 0.787874916469255 0.245202528896225 no 808 0.215384937290276 1029 442583
SGTC_1903 st060211 78.3 µM 0.787522364529713 0.245303027216163 no 809 0.215488070850385 1074 688960
SGTC_475 α-linolenic acid 10 µM 0.786487579343922 0.245598130507093 no 810 0.215790946453696 1149 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1280 0880-0253 10.1 µM 0.785008754054371 0.246020197308601 no 811 0.216224218004485 1038 6836607
SGTC_271 rotenone 740 µM 0.783191276286531 0.246539450377438 no 812 0.216757398482065 1122 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_3194 9111903 49.47 µM 0.783093713208827 0.246567340726199 no 813 0.216786041350809 1054 17087251
SGTC_2179 6298986 200 µM 0.782669834555985 0.246688534502085 no 814 0.216910510357927 1005 738374
SGTC_1112 tnp00069 1.16933 µM 0.78197298721624 0.246887843758709 no 815 0.217115224469065 1103 145826
SGTC_1130 3454-2858 15.9 µM 0.777324190583651 0.248219674885806 no 816 0.21848376319886 996 715628 YIL048W NEO1
SGTC_2945 9067681 61.76 µM 0.77663569776056 0.248417246018849 no 817 0.218686867051235 1114 16456930
SGTC_3006 9075424 71.4286 µM 0.77638756703264 0.248488470597404 no 818 0.218760091696199 1047 7465181
SGTC_1833 st055984 71 µM 0.77464525551081 0.24898889797529 no 819 0.2192746539444 1053 676288
SGTC_3153 9100258 49.47 µM 0.77331812776981 0.24937043562343 no 820 0.219667064999595 1017 25236848
SGTC_2750 bromebric acid 70.15 µM 0.77152701526557 0.249885857184343 no 821 0.220197307958697 1096 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_618 k072-0232 33.2 µM 0.770860527100352 0.250077794179299 no 822 0.220394803088693 1055 5872756 YGL099W LSG1
SGTC_853 0419-0306 21 µM 0.769297339282579 0.250528271734828 no 823 0.220858408197753 1036 762713
SGTC_2306 7482397 179.52 µM 0.768302710128511 0.25081512641306 no 824 0.221153682472456 1074 891448
SGTC_1122 capsaicin 818.572 nM 0.767969752616122 0.250911191408491 no 825 0.221252577575318 1082 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2749 bexarotene 57.39 µM 0.767861256299998 0.25094249900256 no 826 0.221284808635038 1053 82146 An retinoic acid receptor inhibitor.
SGTC_849 0386-0493 241 µM 0.766127488248992 0.251443073824141 no 827 0.221800224260437 1058 726119
SGTC_2203 7227154 166.4 µM 0.764101339876085 0.252028732951623 no 828 0.222403426952171 1102 896304
SGTC_1228 0124-0032 52.5 µM 0.763955232458852 0.252070993172727 no 829 0.2224469605908 1116 X1228
SGTC_1442 4112-3290 3 µM 0.76122034365392 0.252862723912853 no 830 0.223262734567154 1116 704353
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.758159362129244 0.253750406134346 no 831 0.224177792949081 1072 4620898
SGTC_1407 3909-7909 12.3 µM 0.758156646755947 0.253751194316195 no 832 0.22417860563475 1118 4411780
SGTC_2239 6685329 187.64 µM 0.756256908778035 0.254302939464891 no 833 0.22474758922824 1059 805680
SGTC_1401 3807-4679 7.6 µM 0.754196585424367 0.254902033933806 no 834 0.225365593820519 1067 3291456
SGTC_960 1222-0186 7.7 µM 0.75285375646231 0.255292894807365 no 835 0.225768899657966 1096 3126296
SGTC_3301 9125354 19.7965 µM 0.752109319415654 0.255509715034634 no 836 0.225992659986017 1058 41905162
SGTC_954 1189-0853 2.85 µM 0.751705885555501 0.255627256920578 no 837 0.226113975111308 1127 2828194
SGTC_2457 5731572 11.68 µM 0.751289844195793 0.255748501617107 no 838 0.226239119930583 1156 2865357
SGTC_507 nimesulide 162 µM 0.750793873968973 0.255893078772792 no 839 0.22638835838973 1108 4495 A COX2 inhibitor.
SGTC_688 0527-0193 473 µM 0.749213031491374 0.256354184677624 no 840 0.226864407979631 1077 4007154
SGTC_2132 5317594 122.667 µM 0.748125807689172 0.25667156122323 no 841 0.227192138357272 1063 794577
SGTC_508 roscovitine 141 µM 0.748084196478038 0.25668371220873 no 842 0.2272046868499 1138 160355 A CDKinase inhibitor.
SGTC_2947 9072639 7.68 µM 0.747185377197496 0.256946251583842 no 843 0.227475834784538 1152 16488146
SGTC_2778 tioconazole 65.09 nM 0.745674403207498 0.257387912077755 no 844 0.227932062646746 1092 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3302 9125395 16.351 µM 0.74334626899744 0.258069201382437 no 845 0.228636032831045 1083 17599668
SGTC_2490 carminic acid 95.39 µM 0.742722758825266 0.258251819782719 no 846 0.228824773961249 1089 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1013 4112-3890 241 µM 0.741026198517423 0.25874906013354 no 847 0.229338777769154 1054 705171
SGTC_1250 0485-0349 40.2 µM 0.740410327120224 0.258929686754807 no 848 0.229525527215286 1124 6842794 YDL195W SEC31
SGTC_1145 3546-0597 10.2 µM 0.739522633023147 0.259190149956008 no 849 0.22979485076786 1092 875334
SGTC_1539 benzyladenosine 56 µM 0.739015762845725 0.259338934239512 no 850 0.229948712891281 1124 92208 A nucleotide analog.
SGTC_2801 7907800 81.82 µM 0.736705755831966 0.260017561208544 no 851 0.230650652908761 1160 6620925
SGTC_831 k061-1017 217 µM 0.736606857768628 0.260046635614305 no 852 0.230680731686538 1192 1240153
SGTC_2717 st081029 62.2815 µM 0.736109953700748 0.260192742611649 no 853 0.230831892853173 1106 5292846
SGTC_2326 6164455 177.58 µM 0.735935211297581 0.260244132980661 no 854 0.230885063673343 1094 2888790
SGTC_2644 guaiazulene 100 µM 0.735271469448611 0.260439381902907 no 855 0.231087090120105 1150 3515 A coloring agent.
SGTC_1144 3486-0183 12.5 µM 0.734030709673442 0.260804570920248 no 856 0.231465010870442 1145 6744069
SGTC_1629 st005085 44.9 µM 0.733108909229635 0.261076052078908 no 857 0.231746003342604 1142 24207091
SGTC_346 4513-0042 7.16 µM 0.732823032835369 0.261160275568491 no 858 0.231833185652084 1115 2827372
SGTC_2541 muurolladie-3-one 83.07 µM 0.732515331705207 0.261250944554803 no 859 0.231927044154516 1157 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_469 w7 172 µM 0.731723638456817 0.261484303761677 no 860 0.232168632684236 1185 45115570 A P450 inhibitor.
SGTC_1114 scopoletin 1.73284 µM 0.730738327635412 0.2617748830242 no 861 0.23246949995868 1157 5280460 A coumarin with genotoxic properties.
SGTC_1267 0828-0272 9.49 µM 0.730148010140722 0.261949053622945 no 862 0.232649858788821 1161 745334
SGTC_60 0986-0278 202 µM 0.73003714154796 0.261981771543356 no 863 0.232683740979679 998 3110598
SGTC_1136 pergolide 1.05886 µM 0.729520821656152 0.262134167924463 no 864 0.232841567948577 1099 47811 A dopamine receptor agonist.
SGTC_8 0354-0001 70 µM 0.729500639086335 0.262140125910853 no 865 0.232847738497901 1190 4993152
SGTC_1999 st074831 12.5 µM 0.729023819117411 0.262280905517248 no 866 0.232993546216669 1105 17112523
SGTC_2563 tomatine 8.54 µM 0.728241822697043 0.262511871326102 no 867 0.23323278418118 1145 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2300 7976697 71.57 µM 0.724340883471855 0.263665582523592 no 868 0.234428241676671 1057 2236109
SGTC_2954 9074818 52.69 µM 0.722096067407363 0.264330662250235 no 869 0.235117707928847 1121 16648742
SGTC_3014 9081533 49.47 µM 0.721288636128664 0.264570091499688 no 870 0.235365973612102 1157 21367265
SGTC_664 1222-0054 14.9 µM 0.720785004564766 0.264719490251235 no 871 0.235520901441284 1182 6813991
SGTC_2085 5307070 144.047 µM 0.72022325127487 0.264886181000282 no 872 0.235693775116872 1129 2840351
SGTC_3210 9128157 49.47 µM 0.719416792824912 0.265125577084107 no 873 0.235942076533782 1089 17590849
SGTC_1641 st009299 47.1 µM 0.718513165781194 0.265393948016166 no 874 0.236220466487669 1122 4046054
SGTC_188 3229-0966 278.469 µM 0.717276682332993 0.265761398235458 no 875 0.236601695995221 1264 5722370
SGTC_2344 7990960 76.95 µM 0.716320884210674 0.266045612812787 no 876 0.236896617112659 1137 140813
SGTC_1015 4130-4525 82 µM 0.715128474819124 0.266400401434227 no 877 0.237264830183481 1164 1363237
SGTC_3163 9099914 49.47 µM 0.714837819722164 0.266486919012401 no 878 0.237354631384092 1160 16268368
SGTC_742 0kpi-0133 140 µM 0.714438436617233 0.266605824188721 no 879 0.237478055775761 1173 2728852
SGTC_2023 5144124 124 µM 0.714357983930737 0.266629779977285 no 880 0.237502922942575 1152 2830192
SGTC_3108 9121785 49.47 µM 0.714259246543639 0.266659181750359 no 881 0.23753344369128 1143 17140271
SGTC_3099 9120367 49.47 µM 0.711840839580745 0.267379840307324 no 882 0.23828167000274 1217 24824940
SGTC_1160 4092-0570 10.5 µM 0.711194817743159 0.26757251381816 no 883 0.238481759740653 1181 4994975
SGTC_2408 sulbentine 18.36 µM 0.710161360923997 0.267880883794791 no 884 0.238802039342006 1122 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1359 1582-0056 520 nM 0.702635108880441 0.270132003703999 no 885 0.241141588474824 1197 3661189
SGTC_2931 9014674 55.67 µM 0.702518395382554 0.270166987355364 no 886 0.241177966926628 1188 2996810
SGTC_3211 9128781 49.47 µM 0.702412242774915 0.270198807457828 no 887 0.241211056242857 1124 17194361
SGTC_2436 5633522 8.09 µM 0.702387285031819 0.27020628901525 no 888 0.241218836293684 1187 5724242
SGTC_2925 9010536 32.5 µM 0.700946143482662 0.270638474185873 no 889 0.241668313055579 1179 2994177
SGTC_790 1575-0012 79.1 µM 0.700334445372301 0.270822021165749 no 890 0.241859232565434 1225 378741 YLR208W SEC13
SGTC_2213 7173844 200 µM 0.698934690999131 0.271242267029085 no 891 0.242296423146845 1181 892728
SGTC_2526 patulin 37.61 µM 0.697989119807184 0.271526338104649 no 892 0.242591999181399 1226 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_3197 9113331 49.47 µM 0.696575032029148 0.27195143851474 no 893 0.243034392876991 1219 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2141 5621638 7.665 µM 0.696014858847278 0.272119928217565 no 894 0.243209762192368 1194 2856238
SGTC_1626 st003712 1.76 µM 0.695262811222662 0.272346211766412 no 895 0.243445307765868 1168 24207035
SGTC_1445 4239-0156 97.7 µM 0.694465079223073 0.272586343407647 no 896 0.243695296587359 1235 4008346
SGTC_1514 1189-1591 158 µM 0.694223042286542 0.272659221643745 no 897 0.243771172173389 1206 767698 YMR146C TIF34
SGTC_1864 st057645 30.4 µM 0.693474512133544 0.272884668080322 no 898 0.244005907798068 1233 688666
SGTC_2877 9040724 71.43 µM 0.693350485820509 0.272922031934948 no 899 0.244044813653501 1180 6463895
SGTC_1410 3909-8106 77.9 µM 0.693306400950073 0.272935313443068 no 900 0.244058643457192 1217 1039210
SGTC_1304 1165-0502 251 µM 0.691612900703459 0.273445759033101 no 901 0.244590228950891 1209 767425
SGTC_1177 0983-0204 23.6 µM 0.691403751709698 0.273508832353111 no 902 0.244655923533791 1231 766818
SGTC_1911 st060208 74.3 µM 0.690222100844279 0.273865319478803 no 903 0.24502726348925 1211 688783
SGTC_68 0986-0284 82.829 µM 0.688927128869558 0.274256257605744 no 904 0.245434563152626 1167 423278 YIL048W NEO1
SGTC_3145 9085516 49.47 µM 0.68616095126375 0.275092258839143 no 905 0.246305809365834 1215 25236195
SGTC_1619 st003326 88.7 µM 0.685582248582967 0.275267314454159 no 906 0.246488289328723 1186 2849032
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.685332803447897 0.275342787676804 no 907 0.246566968184206 1217 4174840
SGTC_2935 9038016 29.96 µM 0.6846348293529 0.275554023901521 no 908 0.246787191483976 1203 6463195
SGTC_272 doxorubicin 8.13 µM 0.679782814076994 0.277024645945849 no 909 0.248320995053582 1236 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_191 3914-0123 66.505 µM 0.676830938453225 0.277921220670019 no 910 0.249256612997473 1147 3144412
SGTC_1117 retinoic acid 1.10837 µM 0.675318143925538 0.278381250788685 no 911 0.249736829439136 1246 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1596 piperlongumine 63 µM 0.674490759476595 0.278633009438213 no 912 0.249999679274407 1245 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2231 micatex 6.853 µM 0.674490759476595 0.278633009438213 no 913 0.249999679274407 1241 20737 An antifungal of unknown mechanism.
SGTC_2889 9059656 51.95 µM 0.674490759476595 0.278633009438213 no 914 0.249999679274407 1278 3949838
SGTC_783 0848-0141 92.7 µM 0.670863439168667 0.279738046381731 no 915 0.251153764589388 1227 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2374 9071832 200 µM 0.67058074591251 0.279824256080858 no 916 0.251243825822919 1209 17381698
SGTC_2438 5259590 200 µM 0.670014560457548 0.279996957867562 no 917 0.251424254159374 1240 1201127
SGTC_2529 gangaleoidin 93.61 µM 0.668839087925736 0.280355673515582 no 918 0.251799064747119 1279 4565183
SGTC_1240 0356-0016 42.1 µM 0.668605747200072 0.280426907912572 no 919 0.251873502731697 1221 4305613
SGTC_482 fipronil 114 µM 0.668537502812782 0.280447743256156 no 920 0.251895275557098 1261 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1443 4112-3303 14 µM 0.668455236805166 0.2804728604648 no 921 0.251921523188708 1241 704433
SGTC_2972 9093619 59.92 µM 0.668421208935149 0.280483250069502 no 922 0.251932380476421 1233 25236256
SGTC_3070 9117005 49.47 µM 0.668349877106011 0.280505030159722 no 923 0.251955141156492 1266 8779016
SGTC_1840 st055363 71 µM 0.666269209089957 0.281140690433096 no 924 0.252619521396561 1190 676033
SGTC_2321 7390090 138.78 µM 0.664515477224394 0.281677008953106 no 925 0.253180223189724 1187 649046
SGTC_1322 1348-1070 12 µM 0.663755845376489 0.281909469216404 no 926 0.253423295086313 1230 6758089
SGTC_2830 7992007 71.43 µM 0.660930964664746 0.282774740761024 no 927 0.254328293602235 1206 1952075
SGTC_1265 0819-1001 68.8 µM 0.660619946728313 0.282870084633814 no 928 0.254428036908363 1244 3106768
SGTC_569 4130-2812 160 µM 0.659759826801163 0.283133838416897 no 929 0.254703983664846 1175 743552
SGTC_693 4161-2696 114 µM 0.657100832762208 0.283949958229057 no 930 0.255558041743897 1280 805759
SGTC_1295 1013-0063 9.78 µM 0.656905457518388 0.284009968737041 no 931 0.255620854422157 1262 6826038
SGTC_2564 betulinic acid 100 µM 0.656659205227651 0.284085615033638 no 932 0.255700035434937 1297 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_3050 9093513 49.47 µM 0.656414865976807 0.284160683187167 no 933 0.25577861397679 1255 25236664
SGTC_3010 9080089 71.4286 µM 0.654149660341516 0.284857071727548 no 934 0.256507694909461 1265 17027233
SGTC_342 k048-0088 23.3 µM 0.654084928526473 0.28487698408611 no 935 0.256528545443507 1243 6820570
SGTC_1753 st043925 64 µM 0.65393080740357 0.284924396445106 no 936 0.256578192401828 1270 670181
SGTC_678 1218-2179 85.9 µM 0.653265559764528 0.285129090086427 no 937 0.25679254568811 1266 6820081 YOR116C RPO31
SGTC_2774 tamoxifen 10.92 µM 0.652673459384145 0.285311335589098 no 938 0.256983408145483 1292 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_612 0302-0167 22.4 µM 0.650180836855946 0.286079160078838 no 939 0.257787708932564 1298 235821
SGTC_2621 lithochol-11-enic acid 100 µM 0.650000701880647 0.286134686661192 no 940 0.257845884117868 1254 6708711
SGTC_1979 st071809 45.3 µM 0.648636452630375 0.286555382440525 no 941 0.258286693997731 1342 4976333
SGTC_2013 4024628 200 µM 0.645497121842079 0.287524575896208 no 942 0.259302541424092 1305 5230760
SGTC_160 3453-0671 289.699 µM 0.64538625844116 0.28755883063994 no 943 0.259338453111603 1223 5322268
SGTC_1822 st052468 42 µM 0.645166185754548 0.287626834752024 no 944 0.259409748286344 1267 2873678
SGTC_769 0302-0231 76 µM 0.645121597545613 0.287640613769267 no 945 0.259424194402448 1279 571869 YER009W NTF2
SGTC_2005 4024620 188 µM 0.64308854468237 0.288269215753221 no 946 0.260083323563336 1281 236743
SGTC_876 0720-0963 56.8 µM 0.640054493193686 0.289208520722511 no 947 0.261068586320838 1311 765861
SGTC_2194 5927483 104.545 µM 0.639167081452804 0.289483524179113 no 948 0.261357122227283 1290 760979
SGTC_344 k064-0035 6.43 µM 0.634344286995244 0.290980221772276 no 949 0.262928080052274 1258 5088750
SGTC_2240 6690706 185.951 µM 0.630593587205957 0.292146700900818 no 950 0.264153146480884 1225 805876
SGTC_1386 3228-0095 33.8 µM 0.630424279530691 0.29219940739873 no 951 0.264208514842018 1306 870181
SGTC_3085 9117376 49.47 µM 0.63008677626913 0.292304487392217 no 952 0.2643189055124 1349 16480349
SGTC_2150 5556613 200 µM 0.62957970119646 0.292462395772031 no 953 0.264484803915419 1315 743190
SGTC_2206 7254556 146.969 µM 0.629347601481615 0.29253468723082 no 954 0.264560757035274 1282 4398905
SGTC_1367 1812-0510 76.9 µM 0.629309492631116 0.292546557683126 no 955 0.264573228968881 1298 1142582 YDR527W RBA50
SGTC_2163 5671233 125 µM 0.628200375585838 0.292892132424303 no 956 0.26493634214851 1374 701023
SGTC_2976 9009005 19.48 µM 0.628007489160723 0.29295225062509 no 957 0.264999516964193 1320 2993148
SGTC_2323 6148992 148.28 µM 0.627231069030576 0.293194300568734 no 958 0.26525389010577 1261 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_642 0335-0876 158 µM 0.62630666834992 0.293482604491777 no 959 0.265556906664267 1318 6812350
SGTC_1348 1493-0373 93.8 µM 0.624460838033244 0.294058678242717 no 960 0.266162490767615 1316 3010129
SGTC_640 3381-0960 37.1 µM 0.621372591244444 0.295023670516257 no 961 0.267177250791165 1357 1745025
SGTC_323 4013-0906 34.3 µM 0.621011212263336 0.295136686793833 no 962 0.267296122994071 1345 2910086
SGTC_953 1188-0045 9.7 µM 0.618233339448337 0.29600609291245 no 963 0.26821076809818 1336 6144426
SGTC_2242 6630449 61.2675 µM 0.617753867928381 0.29615627464363 no 964 0.268368798575845 1335 691249 YDR170C SEC7
SGTC_2245 6637752 200 µM 0.617686970692409 0.296177231206491 no 965 0.268390851161514 1276 681890
SGTC_1504 k297-0033 30 µM 0.616248418841041 0.296628043670968 no 966 0.268865288273047 1217 4388117
SGTC_2580 diallyl disulphide 81.36 µM 0.616026672243872 0.296697562426614 no 967 0.2689384581635 1333 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1591 genipin 88.4 µM 0.616009337673507 0.296702997222423 no 968 0.268944178485915 1338 442424 A DNA cross-linking agent.
SGTC_909 3448-9333 149 µM 0.61599200313431 0.296708432054045 no 969 0.268949898859129 1296 3344074
SGTC_705 1124-0212 310 µM 0.614532350527206 0.297166234770425 no 970 0.269431801153417 1333 9554485
SGTC_1331 1472-0049 76.2 µM 0.611548525750404 0.298103079261897 no 971 0.270418251690634 1289 24051409
SGTC_427 1354-0053 47.3 µM 0.611442552194285 0.298136376972893 no 972 0.270453319642524 1397 6813657
SGTC_3335 9143315 29.6265 µM 0.607972971570263 0.299227480509186 no 973 0.271602700144447 1309 4899691
SGTC_1889 st059080 5.18 µM 0.607843089391729 0.29926836063721 no 974 0.271645773865901 1335 176925 Isolated from Daphnopsis sellowiana.
SGTC_158 k038-0087 26.446 µM 0.606449286642669 0.299707216362074 no 975 0.272108224239204 1283 X158
SGTC_675 1309-0189 238 µM 0.605740096087442 0.299930625457995 no 976 0.272343677004817 1289 4246530
SGTC_1093 fluphenazine 7.97 µM 0.603541127247794 0.300623822943539 no 977 0.27307438215317 1376 6602611 An atypical antipsychotic.
SGTC_3296 9122258 64.045 µM 0.602020335051038 0.301103656353802 no 978 0.273580300739959 1351 4730474
SGTC_666 0272-0154 136 µM 0.601333483046114 0.301320481841195 no 979 0.273808946235481 1352 6870312
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.600588891016916 0.301555614088704 no 980 0.274056919450022 1366 551469
SGTC_1389 3405-0187 19 µM 0.600302403673391 0.30164610496194 no 981 0.274152358548893 1288 799890
SGTC_1656 st012921 11 µM 0.599657587321569 0.301849823525885 no 982 0.274367229798261 1330 6732821
SGTC_3012 9080433 71.4286 µM 0.598203334363713 0.302309496376663 no 983 0.274852133432329 1349 17688859
SGTC_2544 sphondin 68.51 µM 0.59719347400274 0.302628886413923 no 984 0.275189107875813 1381 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1793 st048256 72.231 µM 0.596648987931942 0.302801154549487 no 985 0.275370878637365 1288 672022
SGTC_1167 k781-0610 148 µM 0.595142368862135 0.30327805744408 no 986 0.2758741547589 1384 4525169
SGTC_873 0591-4978 488 µM 0.595028804260189 0.303314018613851 no 987 0.275912108568895 1500 3305145
SGTC_2160 5660466 132.927 µM 0.59479624816474 0.303387665370252 no 988 0.275989837884241 1304 2859134
SGTC_2317 5986382 200 µM 0.593079172953341 0.3039316824407 no 989 0.276564083983718 1416 877883
SGTC_1937 st074714 47.2 µM 0.592413275691169 0.304142774167199 no 990 0.276786939312088 1305 17250970
SGTC_2367 9070478 135.38 µM 0.592187259443134 0.304214436942955 no 991 0.27686259998799 1368 572802
SGTC_1384 3089-0840 101 µM 0.59218161239799 0.30421622754297 no 992 0.276864490509437 1371 1069836
SGTC_1520 flindersine 88 µM 0.590168837794165 0.304854749362056 no 993 0.277538730915382 1499 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1459 k035-0031 35.7 µM 0.589272480814175 0.305139296380957 no 994 0.277839251113199 1248 3877128 YMR208W ERG12
SGTC_2666 tannic acid 100 µM 0.589069051570751 0.305203891064112 no 995 0.277907476628264 1390 16134267 A thiamine antagonist.
SGTC_2104 5389443 200 µM 0.588836564070382 0.305277720016051 no 996 0.277985457629423 1436 2244536
SGTC_2335 9018011 154.17 µM 0.587941874756951 0.305561912294618 no 997 0.278285654060428 1408 6458208
SGTC_2355 9061122 103.12 µM 0.587754203391445 0.305621539765181 no 998 0.278348643758143 1358 5302957
SGTC_1414 3917-0015 5.4 µM 0.587698008878255 0.305639395045878 no 999 0.278367506140758 1352 6618702
SGTC_981 1488-1094 54.9 µM 0.585353151296764 0.306384863189572 no 1000 0.279155141416492 1322 3449522
SGTC_111 0083-0039 52.457 µM 0.584549607316471 0.306640507499664 no 1001 0.279425300048006 1282 759313
SGTC_2606 farnesol 9.78 µM 0.58375554252187 0.306893228492592 no 1002 0.279692396382668 1416 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2675 theaflavin digallate 100 µM 0.583612074155506 0.306938898878205 no 1003 0.279740667463442 1360 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_216 k038-0035 28.382 µM 0.583540650123606 0.306961636457468 no 1004 0.279764700157972 1313 4444231 YPR107C YTH1
SGTC_526 4469-0568 170 µM 0.582743702549598 0.307215392149629 no 1005 0.280032924290899 1349 2901964
SGTC_660 4031-1742 102 µM 0.582719672923392 0.307223044845958 no 1006 0.280041013741769 1302 6738706
SGTC_977 1348-1378 135 µM 0.582118270173243 0.307414600447298 no 1007 0.280243509789926 1337 X977
SGTC_2984 9022109 38.96 µM 0.579947194540214 0.308106556805426 no 1008 0.280975114113181 1391 6459207
SGTC_746 1095-0025 46.6 µM 0.579936559521604 0.308109948037173 no 1009 0.28097870014904 1386 6749286
SGTC_1555 citronellol 128 µM 0.577004458053016 0.309045543255918 no 1010 0.281968221985902 1375 8842 A terpine precursor.
SGTC_2905 7799065 20.05 µM 0.576528871731704 0.309197413664598 no 1011 0.282128880321536 1361 1296806
SGTC_2539 epi(13)torulosol 80 µM 0.576464005529513 0.309218130111466 no 1012 0.282150796259113 1335 6708597
SGTC_1159 4092-0538 61.2 µM 0.576377964145046 0.309245610253958 no 1013 0.282179867787403 1413 717301
SGTC_200 k038-0079 37.545 µM 0.574589102071923 0.309817183659439 no 1014 0.282784612080425 1388 3436683
SGTC_1466 k213-0079 57.5 µM 0.573800538492808 0.310069290010586 no 1015 0.283051392158068 1363 3657981
SGTC_2082 5219693 150 µM 0.572809559913593 0.310386235736727 no 1016 0.283386822737541 1345 2834649
SGTC_892 0929-0076 29 µM 0.57226460812796 0.310560588284578 no 1017 0.283571361479732 1367 5751038
SGTC_1687 st020778 55.3625 µM 0.572224359926812 0.310573467032154 no 1018 0.28358499313802 1385 4259299
SGTC_1756 st041558 35.5 µM 0.57175567064435 0.310723456811668 no 1019 0.283743756564428 1485 3955792
SGTC_908 3448-7491 47.7 µM 0.570522390072671 0.311118281094457 no 1020 0.284161720252213 1375 1203031
SGTC_1 0258-0098 57.368 µM 0.570485532194181 0.311130084179435 no 1021 0.284174216063319 1312 6790032 YDR047W HEM12
SGTC_1321 1326-2144 215 µM 0.565071582418891 0.312865910412976 no 1022 0.286012538264549 1414 3513030
SGTC_562 3772-2733 112 µM 0.564682714897907 0.312990749997168 no 1023 0.286144796598918 1385 2876874 YIL048W NEO1
SGTC_2446 5162541 200 µM 0.563640261981369 0.313325518296038 no 1024 0.286499490132899 1355 1549321
SGTC_2865 9030313 51.95 µM 0.562508535819541 0.313689129583499 no 1025 0.286884794799817 1337 42562754
SGTC_544 k015-0020 52.4 µM 0.561421760742338 0.314038469013308 no 1026 0.287255026476987 1402 3008304
SGTC_366 0181-0206 4.31 µM 0.560994453734975 0.314175870791161 no 1027 0.287400659065576 1482 274874
SGTC_310 1273-0058 1.06 µM 0.55998790044919 0.3144996326234 no 1028 0.287743845363855 1387 2734232
SGTC_2319 6033012 152.6 µM 0.559733063907589 0.314581624450759 no 1029 0.287830763082764 1346 847246
SGTC_332 4112-0506 40.9 µM 0.5584566759998 0.314992430636461 no 1030 0.288266290305723 1421 2790355
SGTC_2484 5809818 12.04 µM 0.557007539466159 0.315459113622631 no 1031 0.288761138985549 1406 2870548
SGTC_1234 0326-0494 15.5 µM 0.555006809501561 0.316103916859229 no 1032 0.289445001392378 1478 1547813
SGTC_1824 st053723 68.6 µM 0.551872232591224 0.317115265822696 no 1033 0.290517946966439 1364 675225
SGTC_1062 mesoridazine 14.2 µM 0.551350466036348 0.317283743057476 no 1034 0.290696724855751 1413 4078 A neuroleptic.
SGTC_1676 st018489 23.4 µM 0.551188919877701 0.317335913624115 no 1035 0.290752087398573 1430 3696235
SGTC_65 0798-0905 34.986 µM 0.549851496168582 0.317767967599455 no 1036 0.291210617344493 1609 3602145
SGTC_832 4083-0019 164 µM 0.548677843398686 0.318147320011487 no 1037 0.291613277040293 1541 1990758
SGTC_1491 4138-0063 26.5 µM 0.548003802435536 0.318365272340314 no 1038 0.291844645964205 1397 23883227
SGTC_221 trifluoperazine 10.304 µM 0.547954002433281 0.318381377754054 no 1039 0.291861743529232 1385 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1797 st048695 56.8 µM 0.546861203347085 0.318734877385086 no 1040 0.292237045719702 1439 592262 YIL048W NEO1
SGTC_583 1488-1091 88.9 µM 0.544271182206859 0.319573358291958 no 1041 0.293127437307312 1485 4303273
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.543915413041885 0.319688605488169 no 1042 0.293249841033506 1444 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2135 5326629 150.42 µM 0.541506343305253 0.320469452710114 no 1043 0.294079313319126 1394 5020077
SGTC_2265 7929201 200 µM 0.541217834039329 0.320563020070158 no 1044 0.294178723269383 1375 1265108
SGTC_3294 9122953 26.2835 µM 0.540643568698626 0.320749295830901 no 1045 0.294376640714674 1397 16459826
SGTC_1209 2323-2347 50.3 µM 0.540292069887854 0.320863334578334 no 1046 0.294497813203654 1429 5412760
SGTC_351 caspofungin 25 nM 0.540120332697031 0.320919058394298 no 1047 0.294557024683768 1514 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1741 st038134 10.228 µM 0.539713506101546 0.321051078106726 no 1048 0.294697312109833 1545 1272587
SGTC_1796 st049173 110.4 µM 0.539439984186065 0.32113985170164 no 1049 0.29479164894036 1389 94134
SGTC_872 0588-0139 234 µM 0.538635875666547 0.321400890354835 no 1050 0.295069063984017 1411 2047100
SGTC_2403 6032726 181.2 µM 0.537836411092561 0.321660508917081 no 1051 0.295344996021927 1436 2881040
SGTC_1370 2001-0092 44.6 µM 0.536941909841149 0.321951093004346 no 1052 0.295653870257721 1597 790957
SGTC_3146 9095609 49.47 µM 0.535200025997617 0.32251726680593 no 1053 0.296255774165309 1487 17173999
SGTC_1350 1495-0454 146 µM 0.534918281768888 0.322608882364069 no 1054 0.296353183007075 1484 1069057
SGTC_2844 9010103 25.97 µM 0.532097874216615 0.323526594991931 no 1055 0.297329104817193 1429 2480525
SGTC_2938 9059746 27.26 µM 0.53178426108981 0.323628705844907 no 1056 0.297437712370875 1463 6471769
SGTC_1996 st072960 66.8 µM 0.531689911587584 0.323659428166179 no 1057 0.297470390149626 1421 1719405
SGTC_315 k915-0449 187 µM 0.531091583775693 0.323854285137112 no 1058 0.297677658053253 1492 20970215 YNL149C PGA2
SGTC_276 colchicine 750 µM 0.53080109741243 0.323948905029204 no 1059 0.297778309757955 1461 2833 A microtubule depolymerizer.
SGTC_1925 st057770 10.1 µM 0.530278415510909 0.324119186437382 no 1060 0.297959454846106 1349 5989122
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.529249260631616 0.32445457618915 no 1061 0.298316274260537 1492 5377381
SGTC_636 0kpi-0074 126 µM 0.528795825472544 0.324602390718891 no 1062 0.298473546972216 1428 616434
SGTC_1125 tnp00248 1.32998 µM 0.528599575561281 0.324666374451173 no 1063 0.298541627398167 1555 24207736
SGTC_2236 dapsone 200 µM 0.527820630276215 0.324920386479697 no 1064 0.298811918436485 1425 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_77 0828-0286 12.516 µM 0.52674791530012 0.325270329288979 no 1065 0.299184328345898 1396 745345
SGTC_552 k242-0005 476 µM 0.524935861571421 0.325861810372004 no 1066 0.299813889288397 1450 4088318
SGTC_2350 9023895 38.85 µM 0.524869171056256 0.325883587516361 no 1067 0.299837070981626 1512 2997209
SGTC_645 0845-0943 5.41 µM 0.52452018419212 0.325997555496204 no 1068 0.299958392414527 1430 1885106
SGTC_885 0865-0106 16.8 µM 0.522585410739715 0.326629685459105 no 1069 0.300631397649015 1396 2793380
SGTC_2123 5259487 200 µM 0.522507769922867 0.326655062704395 no 1070 0.300658418998529 1502 2173474
SGTC_94 0334-0113 514.748 µM 0.52220287922939 0.326754725337801 no 1071 0.300764540773134 1388 6795178
SGTC_986 1493-0483 84 µM 0.521811685894617 0.326882616674215 no 1072 0.300900726223261 1427 40079
SGTC_1685 st024049 53.0905 µM 0.52082460432961 0.327205409842285 no 1073 0.301244480746826 1436 1941139
SGTC_3244 9134489 49.47 µM 0.52057828502954 0.327285980784457 no 1074 0.301330289852687 1403 16584271
SGTC_2055 5235184 200 µM 0.518368676578777 0.328009102319485 no 1075 0.302100532488645 1466 2836034
SGTC_211 3455-0679 143.504 µM 0.51799101856655 0.328132760181546 no 1076 0.302232267885541 1457 748649
SGTC_375 3970-0961 9.27 µM 0.517575038801663 0.328268987669389 no 1077 0.302377400578253 1477 2898222
SGTC_1317 1273-0028 910 nM 0.512893893290821 0.329803567648291 no 1078 0.304012772683699 1445 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2571 chrysanthemic acid 100 µM 0.512736204666606 0.329855311459925 no 1079 0.304067930263974 1398 2743 An insecticide.
SGTC_1768 st044301 37.178 µM 0.510807677079643 0.330488400031565 no 1080 0.304742866468849 1433 3931349
SGTC_1946 st076057 65.1 µM 0.508780654523745 0.331154345352249 no 1081 0.305452990444553 1401 953009
SGTC_1024 4507-0395 26 µM 0.508010254614652 0.331407587996622 no 1082 0.305723075849021 1503 4201836
SGTC_3033 9090887 49.47 µM 0.50781068850201 0.331473201114812 no 1083 0.305793056620778 1426 19325384
SGTC_1550 gossypolone 36.6 µM 0.506905247290175 0.331770955984851 no 1084 0.306110651860005 1459 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_626 0214-0009 33 µM 0.506552272199068 0.331887060858213 no 1085 0.306234501956613 1564 3437874
SGTC_3257 9139206 32.98 µM 0.504178070224651 0.332668431421781 no 1086 0.307068124707541 1488 4910041
SGTC_1239 0337-0584 35.4 µM 0.503933578041327 0.332748937300766 no 1087 0.307154026841098 1618 914301 YML130C ERO1
SGTC_1710 st031758 61.5 µM 0.503082396309062 0.333029272799528 no 1088 0.307453171407104 1558 5394341
SGTC_932 2857-0803 154 µM 0.502831081954639 0.333112060680914 no 1089 0.307541519382933 1596 674898
SGTC_1022 4477-0945 21.3 µM 0.502782813784162 0.333127962094928 no 1090 0.307558489032017 1461 4648966
SGTC_2467 5474540 200 µM 0.501605766097972 0.333515820214136 no 1091 0.307972431290847 1444 5413519
SGTC_300 r073-0011 5.04 µM 0.50150398442819 0.333549367450808 no 1092 0.308008237196667 1500 2735780
SGTC_134 0269-0018 6.916 µM 0.499096949042257 0.334343113716806 no 1093 0.308855543401496 1423 4378915
SGTC_1092 toremifene 6.32 µM 0.497913361173444 0.334733686857075 no 1094 0.309272554734615 1470 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1021 4476-0760 85.3 µM 0.496184349040534 0.335304566426134 no 1095 0.309882176125495 1453 746768
SGTC_1152 3909-8331 15.9 µM 0.491774140631907 0.336762435381433 no 1096 0.31143950960934 1482 16001939
SGTC_1540 guanosine 70.6 µM 0.489466134322681 0.337526366490473 no 1097 0.312255862397428 1479 6802 Guanosine is a purine nucleoside
SGTC_1133 3473-0247 50 µM 0.488371315415168 0.337888977065521 no 1098 0.312643427916639 1426 711311
SGTC_2316 5844804 197.44 µM 0.485920655432095 0.338701195377876 no 1099 0.313511711455064 1564 776813
SGTC_1798 st045719 60.953 µM 0.485909129372093 0.338705017217969 no 1100 0.313515797654825 1447 3980186
SGTC_904 1141-0088 396 µM 0.48500113381289 0.339006144838227 no 1101 0.313837770620983 1417 1378119
SGTC_1594 piperine 70.1 µM 0.484447120233901 0.339189928440614 no 1102 0.314034292135629 1465 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1203 3992-3522 103 µM 0.483706603793412 0.339435640619636 no 1103 0.31429705292718 1726 5322312
SGTC_715 0868-0130 184 µM 0.482873770393318 0.339712066239022 no 1104 0.314592683427395 1644 2876258
SGTC_1393 3470-5649 58.2 µM 0.482814520796708 0.339731735051685 no 1105 0.314613719762884 1469 4108395
SGTC_195 4234-0266 16.654 µM 0.482708675597248 0.339766873075746 no 1106 0.314651301181044 1485 2303354
SGTC_235 0330-0087 5 mM 0.482395213244708 0.339870943096708 no 1107 0.314762610450617 1480 46494818 YHR062C RPP1
SGTC_2459 5811157 9.22 µM 0.481780115848778 0.340075191919578 no 1108 0.31498107807233 1473 2870684 YBR192W RIM2
SGTC_2769 toremifene 3.73 µM 0.481007208332679 0.340331909612757 no 1109 0.315255687799932 1535 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2966 9084041 48.03 µM 0.478352415273123 0.341214250076047 no 1110 0.316199697901351 1374 17741380
SGTC_2909 7941780 10.49 µM 0.478096315373629 0.341299412832729 no 1111 0.316290827239307 1570 1243215
SGTC_3128 9127691 49.47 µM 0.477862742524838 0.341377091553856 no 1112 0.316373950391103 1520 41316314
SGTC_381 3461-2219 42.7 µM 0.477688693813227 0.34143497885594 no 1113 0.316435896318095 1592 2883159
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.477053437491576 0.341646292013469 no 1114 0.316662035002808 1556 756377
SGTC_1760 st045453 10.4495 µM 0.476918265380322 0.341691262389472 no 1115 0.316710162446994 1560 3323419 YIL048W NEO1
SGTC_620 0109-0052 432 µM 0.476826065930131 0.341721937490597 no 1116 0.316742991441464 1579 493037
SGTC_246 cycloheximide 667 µM 0.476204572703895 0.341928737865423 no 1117 0.316964321052137 1464 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_410 α-linolenic acid 100 µM 0.468400025972502 0.344529702135118 no 1118 0.319749274734546 1585 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1897 st060201 15 µM 0.4677104981706 0.344759852033858 no 1119 0.319995816300888 1482 611878
SGTC_428 3448-4153 16.5 µM 0.466514807068691 0.345159084790507 no 1120 0.320423525674048 1453 3834874
SGTC_20 0481-0013 4.944 µM 0.466119592064462 0.345291082199581 no 1121 0.320564950106438 1501 182045
SGTC_3217 9129673 49.47 µM 0.46572773832404 0.345421975565702 no 1122 0.320705197462118 1533 17248312
SGTC_2243 6634756 200 µM 0.463201216051771 0.346266368964088 no 1123 0.321610072335851 1628 885676
SGTC_2875 9039966 71.43 µM 0.4627929984846 0.346402871938878 no 1124 0.321756375156219 1642 6463691
SGTC_1084 voriconazole 435 nM 0.461651771149326 0.346784590244003 no 1125 0.32216553104507 1570 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_462 ag-879 158 µM 0.460515898805886 0.347164671904773 no 1126 0.322572981153653 1613 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2425 5628681 7.85 µM 0.459933633948802 0.347359566995776 no 1127 0.322781928745328 1622 5714958
SGTC_2517 totarol 10 µM 0.459523371993747 0.347496913697151 no 1128 0.322929186161166 1476 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1472 k841-0093 193 µM 0.457518580366663 0.348168361652928 no 1129 0.323649175208197 1612 X1472
SGTC_530 4358-1714 28 µM 0.457111824364988 0.34830465119156 no 1130 0.323795335859092 1590 1564641
SGTC_1408 3909-7976 48.8 µM 0.456022836552469 0.34866962885161 no 1131 0.324186778305016 1575 24152374
SGTC_920 mycophenolic acid 780.421 nM 0.454902453765733 0.349045274865671 no 1132 0.324589708766353 1540 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2903 5923464 63.88 µM 0.454623391928229 0.349138862765875 no 1133 0.324690101537415 1560 2876576
SGTC_663 1486-0733 13.9 µM 0.45388889694738 0.349385231380301 no 1134 0.324954397696405 1549 722445 YPR165W RHO1
SGTC_1151 3909-8316 15.3 µM 0.452788574972006 0.349754426566213 no 1135 0.32535049565181 1532 800431
SGTC_581 0958-0271 211 µM 0.452075154053147 0.349993879352092 no 1136 0.32560742104636 1496 4591145
SGTC_1411 3909-8223 150 µM 0.451144997374023 0.350306166980798 no 1137 0.325942524282519 1637 X1411
SGTC_800 3448-7362 155 µM 0.449188677568747 0.35096330525568 no 1138 0.326647777269854 1605 15991913
SGTC_1628 st004252 77.7 µM 0.448736206383904 0.351115356322243 no 1139 0.326810981425225 1671 692968
SGTC_771 0250-0039 27.3 µM 0.446082496935243 0.352007603582704 no 1140 0.327768827795701 1564 3005115
SGTC_2871 9038510 12.99 µM 0.44448304658863 0.352545775279872 no 1141 0.328346691666776 1702 4945164
SGTC_3009 9080819 71.4286 µM 0.444093508823719 0.352676888938057 no 1142 0.328487489667313 1546 17027216
SGTC_777 1315-0167 517 µM 0.442803593220388 0.353111183651477 no 1143 0.328953902045175 1512 4221767
SGTC_3253 9135987 49.47 µM 0.442797640026359 0.353113188444332 no 1144 0.328956055240983 1581 4182430
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.441505906521731 0.353548287916818 no 1145 0.329423393216796 1500 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_840 0245-0196 390 µM 0.440565121163617 0.353865296715522 no 1146 0.329763929026701 1632 3827528
SGTC_139 0099-0334 718.624 µM 0.440484817932691 0.353892360540234 no 1147 0.329793002907324 1595 97690
SGTC_517 1365-0151 113 µM 0.43991534358157 0.354084306172514 no 1148 0.329999211273667 1596 768657
SGTC_834 0312-0008 75.7 µM 0.43981160195436 0.354119277066224 no 1149 0.330036781992154 1586 6385573 YIL048W NEO1
SGTC_586 0957-0265 8.15 µM 0.439574500356223 0.354199207699845 no 1150 0.3301226563445 1530 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1816 st051957 91.6 µM 0.438608121520607 0.35452505544047 no 1151 0.330472755624857 1575 674121
SGTC_405 ebelactone b 50 µM 0.438371211494288 0.35460495403756 no 1152 0.330558605943964 1546 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_774 k060-0086 136 µM 0.437564504174769 0.354877066395502 no 1153 0.330851003522921 1721 5911235
SGTC_348 k064-0012 10.7 µM 0.436573161132514 0.355211560070111 no 1154 0.331210465168609 1538 5066323
SGTC_223 busulfan 5 mM 0.436237401540488 0.355324875589473 no 1155 0.331332247110282 1612 2478 A DNA alkylator.
SGTC_181 1447-1644 8.07 µM 0.435275628149029 0.355649535306948 no 1156 0.331681186566253 1649 534600
SGTC_1767 st044992 70.3 µM 0.430045603780889 0.357416829422381 no 1157 0.333581234042754 1522 9600693
SGTC_1904 st060225 78 µM 0.429489481773426 0.35760493115642 no 1158 0.333783523391892 1539 66595
SGTC_2003 4023581 200 µM 0.429360509524344 0.357648559447335 no 1159 0.333830443944933 1579 16641307
SGTC_2044 5102272 200 µM 0.428847042413757 0.357822271782628 no 1160 0.334017270824508 1579 592666
SGTC_1724 st037281 8.293 µM 0.428425828658584 0.357964795645684 no 1161 0.334170561705695 1548 574124 YDL195W SEC31
SGTC_611 3453-1652 23.7 µM 0.427697072416288 0.358211427780668 no 1162 0.334435840797761 1650 1560575
SGTC_432 NS 1619 61.3 µM 0.427156966858185 0.358394253267778 no 1163 0.33463250134396 1611 4552 A K+/calcium channel activator.
SGTC_2887 9044784 58.44 µM 0.426970140196017 0.358457501567755 no 1164 0.334700538303008 1549 6465546
SGTC_1636 st007707 68.9 µM 0.426327931058263 0.358674944660712 no 1165 0.334934453995822 1691 403051
SGTC_3181 9108277 49.47 µM 0.425402646339045 0.358988313760413 no 1166 0.335271588613725 1540 17097298
SGTC_70 0141-0289 43.283 µM 0.424113143882471 0.359425191910494 no 1167 0.335741650098897 1669 352408
SGTC_123 0083-0120 66.675 µM 0.423290333103369 0.359704052940994 no 1168 0.336041723201481 1521 16001701
SGTC_2641 levomentholum 100 µM 0.423277168128027 0.359708515326095 no 1169 0.336046525222236 1588 16666
SGTC_1567 st069303 68.4 µM 0.423189676769276 0.35973817178366 no 1170 0.336078439013135 1583 5581319
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.422349895651902 0.360022870637034 no 1171 0.33638482189874 1623 66535 A nucleotide analog.
SGTC_62 0180-0423 3.232 µM 0.422169283991455 0.360084110950671 no 1172 0.336450729849891 1586 30102 YGL099W LSG1
SGTC_1126 isoteolin 1.0172 µM 0.42115295765379 0.360428785428586 no 1173 0.33682169649606 1513 133323
SGTC_951 1171-0579 82.7 µM 0.420866435908391 0.360525976238701 no 1174 0.336926307768719 1518 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2272 7805186 180 µM 0.417877926709829 0.361540242143246 no 1175 0.338018185948526 1627 2956062 YPR165W RHO1
SGTC_2643 anethole 100 µM 0.41711180606355 0.361800411833474 no 1176 0.338298314924021 1596 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_441 propafenone 146 µM 0.415609374009003 0.362310813592215 no 1177 0.338847933072914 1573 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1896 st058441 89 µM 0.41541864748401 0.362375624175537 no 1178 0.338917729031954 1557 688759
SGTC_3041 9091929 49.47 µM 0.414394582464773 0.362723678060906 no 1179 0.339292577920162 1649 25236887
SGTC_48 0382-0018 55 µM 0.414161490286128 0.362802916077855 no 1180 0.339377921251327 1729 762596
SGTC_1901 st060216 58.6 µM 0.413502922688214 0.36302682315561 no 1181 0.339619090767915 1578 688792
SGTC_2182 6325192 200 µM 0.413040619046527 0.363184030227095 no 1182 0.339788427052837 1605 736248
SGTC_2226 7298446 200 µM 0.412676941260141 0.363307715624466 no 1183 0.339921660595663 1686 3283010
SGTC_3324 9138759 60.749 µM 0.41093922013624 0.363898904368146 no 1184 0.340558551419381 1622 45595710
SGTC_1947 st076332 61.6 µM 0.406128539681238 0.365537229014948 no 1185 0.342324078435978 1647 24208416
SGTC_1713 st033146 12.748 µM 0.406063637256629 0.365559349033405 no 1186 0.34234792140639 1724 674619
SGTC_2989 9073649 71.4286 µM 0.404932014170709 0.365945100162133 no 1187 0.342763742630948 1716 21367202
SGTC_2568 diosmetin 100 µM 0.40380142488624 0.366330634265391 no 1188 0.343179374304011 1666 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2681 menadione 3.18 µM 0.402484899291985 0.366779743223861 no 1189 0.343663599762524 1623 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1189 1431-2119 7.28 µM 0.402391416963966 0.366811639977508 no 1190 0.343697992851564 1635 3107275
SGTC_1131 3454-3128 32.3 µM 0.40156199890791 0.367094682847501 no 1191 0.344003200733178 1731 710982
SGTC_1503 4585-0012 61.3 µM 0.399959064626261 0.367641896445223 no 1192 0.344593333788925 1697 2922052
SGTC_2091 4-phenylthiadiazole 200 µM 0.399843523388071 0.367681350593436 no 1193 0.344635885856721 1639 270010
SGTC_390 dec-rvkr-cmk 16.7 µM 0.39982671521042 0.367687090239182 no 1194 0.344642076214834 1657 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1873 rapamycin 2 nM 0.399103504533349 0.367934079732551 no 1195 0.344908470059847 1606 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1893 st059353 36.1 µM 0.398812444011953 0.368033497569725 no 1196 0.34501570358711 1581 3112488
SGTC_35 0133-0054 64.071 µM 0.398805687039082 0.368035805660809 no 1197 0.345018193162379 1535 99677
SGTC_1274 0865-0114 173 µM 0.397103079181011 0.368617545249407 no 1198 0.345645724687132 1649 870624
SGTC_400 oxethazaine 37.5 µM 0.39674679004475 0.368739318716666 no 1199 0.345777096207449 1611 4621 A local anesthetic.
SGTC_2188 6126565 140.678 µM 0.395948520006215 0.369012201446822 no 1200 0.346071503055302 1688 874518
SGTC_1123 mangostin 811.285 nM 0.395107950037407 0.369299615474311 no 1201 0.346381610969012 1606 5281650 An antioxidant.
SGTC_1420 4'-methoxyflavone 42 µM 0.393923617332952 0.369704695429113 no 1202 0.346818716581476 1743 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1859 st055998 20 µM 0.39378796836461 0.36975110098864 no 1203 0.346868794026477 1773 676301
SGTC_1952 st077036 64.1 µM 0.393774074850588 0.369755854071755 no 1204 0.346873923237417 1608 2937007
SGTC_2791 5663188 71.43 µM 0.392723017661106 0.370115486854054 no 1205 0.347262034090276 1726 54690634
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.392339527125003 0.370246731390084 no 1206 0.347403680800952 1728 165506
SGTC_680 0417-1641 114 µM 0.391778747354992 0.370438678004319 no 1207 0.34761084972813 1618 2835990
SGTC_695 3505-6186 243 µM 0.388684149054359 0.371498492247854 no 1208 0.348754904700857 1688 1819379
SGTC_2365 9042475 200 µM 0.388395723759365 0.371597319713735 no 1209 0.348861604143248 1622 6464479
SGTC_1385 3091-4834 14.1 µM 0.387644161836539 0.371854878344967 no 1210 0.349139691504538 1705 4072814
SGTC_2254 7938975 95.19 µM 0.387254341630244 0.371988491478219 no 1211 0.34928396180454 1753 2969277
SGTC_1617 st002906 78 µM 0.386405159167014 0.372279607037723 no 1212 0.349598314909455 1634 5150859
SGTC_454 lyso-paf C-16 6.67 µM 0.384591995545331 0.37290143745243 no 1213 0.350269862730992 1548 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1293 1000-1278 195 µM 0.384518031898334 0.372926810571837 no 1214 0.350297266865679 1706 678847
SGTC_3286 9117135 37.221 µM 0.38416655712545 0.373047391003509 no 1215 0.350427501786322 1586 3438150
SGTC_2680 butyl paraben 22.24 µM 0.383880696487835 0.373145470368978 no 1216 0.350533437115085 1660 7184 An antifungal and steroid mimetic.
SGTC_2630 antimycin a 100 µM 0.382770640407597 0.373526410757918 no 1217 0.35094491610221 1580 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1615 st002656 86.5 µM 0.381993858263129 0.373793054338734 no 1218 0.351232960113008 1633 1584458
SGTC_2701 st077767 14.721 µM 0.381583206518064 0.373934041900883 no 1219 0.351385271304249 1644 5721188
SGTC_278 4092-0821 23.9 µM 0.381202882170563 0.374064632314082 no 1220 0.351526355319986 1709 877900
SGTC_2028 5153890 36.43 µM 0.380647032323682 0.374255518195289 no 1221 0.351732588556103 1626 2830968 YPR165W RHO1
SGTC_1621 st003705 32.4 µM 0.380133631292058 0.374431854006078 no 1222 0.351923111062797 1752 24207032
SGTC_394 menadione 8.33 µM 0.379354995191291 0.374699339169671 no 1223 0.352212132936793 1697 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3168 9103419 49.47 µM 0.378722936527187 0.374916514876689 no 1224 0.35244680953688 1684 16649256
SGTC_2116 5511452 16.8835 µM 0.378036230893955 0.375152512274151 no 1225 0.352701839646264 1680 870744
SGTC_1707 st032323 6.317 µM 0.377569749312018 0.375312852813818 no 1226 0.352875120281204 1680 3132057 YMR211W DML1
SGTC_2487 5918373 44.05 µM 0.377541327293473 0.375322622817431 no 1227 0.352885678995517 1737 2876279
SGTC_1111 tnp00062 510.699 nM 0.377463619586439 0.375349335071514 no 1228 0.352914547807721 1780 676306
SGTC_1166 k206-0078 225 µM 0.375021619740634 0.376189083647139 no 1229 0.353822193949183 1623 5404595
SGTC_2337 9009472 200 µM 0.373170828633291 0.376825919835587 no 1230 0.354510652974777 1758 5742383
SGTC_1311 1190-0148 100 µM 0.37263291863217 0.377011071515609 no 1231 0.354710834546787 1769 1961333
SGTC_553 k007-0256 45.7 µM 0.372521441243397 0.377049446206062 no 1232 0.354752325539803 1694 6287000
SGTC_2087 5276107 200 µM 0.372302622439889 0.377124775361051 no 1233 0.354833773159494 1640 144405
SGTC_731 3966-0296 387 µM 0.372294539800286 0.377127557928192 no 1234 0.354836781765507 1671 660956
SGTC_3350 9150499 3.57 µM 0.369484908937162 0.378095200186149 no 1235 0.355883159788053 1646 4910996 YPR165W RHO1
SGTC_722 3534-0461 190 µM 0.369463864516337 0.378102450819736 no 1236 0.35589100137544 1638 658262
SGTC_1282 0886-0010 32.4 µM 0.36893947764651 0.378283136651282 no 1237 0.356086418472404 1795 2836211 YNL267W PIK1
SGTC_554 4483-2211 187 µM 0.368048571833603 0.378590173424159 no 1238 0.356418508542484 1685 747107
SGTC_2394 5221648 200 µM 0.367619108029365 0.378738208810696 no 1239 0.356578632469126 1806 788586
SGTC_2846 9008642 19.48 µM 0.367164591991428 0.378894899036142 no 1240 0.356748124561591 1659 2992898
SGTC_1333 1482-0047 286 µM 0.365694353082478 0.379401886595408 no 1241 0.357296580145638 1773 3811116
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.36550431952225 0.379467431682258 no 1242 0.35736749151068 1787 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1146 3579-1023 7 µM 0.365337234060207 0.379525064528785 no 1243 0.357429843820908 1791 X1146
SGTC_2451 5856223 45.7 µM 0.364210738810065 0.379913696730702 no 1244 0.357850324248915 1632 2179896
SGTC_1308 1187-1617 41.4 µM 0.362916730024689 0.380360269504384 no 1245 0.358333544413025 1664 2882570
SGTC_2014 4013930 200 µM 0.362876651145263 0.380374103595696 no 1246 0.358348514648988 1743 64556
SGTC_355 1311-2252 105 µM 0.362828001864589 0.380390896151782 no 1247 0.35836668638797 1638 5338538
SGTC_896 0964-0007 44.5 µM 0.362258580140202 0.380587463522997 no 1248 0.358579403668668 1778 6756758
SGTC_145 3737-0113 38.366 µM 0.361618372995282 0.380808503212389 no 1249 0.358818616463195 1819 6849351
SGTC_946 3434-1334 87.4 µM 0.360584468391516 0.381165554102017 no 1250 0.359205050853981 1746 4047976
SGTC_1354 1498-1681 81 µM 0.359974315992798 0.381376312971369 no 1251 0.359433170349088 1700 5754243
SGTC_1448 4255-0083 152 µM 0.357954608881131 0.382074210959993 no 1252 0.360188641323357 1815 5399660
SGTC_3007 9078383 71.4286 µM 0.357338640891699 0.382287131489074 no 1253 0.360419152856344 1669 6496995
SGTC_1326 1431-2094 10.8 µM 0.355900723168057 0.382784312325107 no 1254 0.360957457102496 1651 616278
SGTC_1715 st032160 10.2275 µM 0.355815411621506 0.38281381610511 no 1255 0.360989403320256 1773 5289825
SGTC_3213 9129884 49.47 µM 0.355070994315194 0.383071291036454 no 1256 0.361268202931508 1564 17190742
SGTC_2031 5180455 200 µM 0.352878183854869 0.383830028027655 no 1257 0.362089883405711 1684 29949
SGTC_2603 homopterocarpin 100 µM 0.352521534114272 0.383953475037798 no 1258 0.362223585887764 1686 101795 A weak amylase inhibitor.
SGTC_2757 clomiphene 4.22 µM 0.35245567268302 0.383976272913056 no 1259 0.362248278160928 1839 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_373 0844-0104 25.9 µM 0.351819779003458 0.384196407580316 no 1260 0.36248671211311 1813 5375804
SGTC_1635 st007035 42.4 µM 0.350439873585724 0.384674233808951 no 1261 0.363004303217983 1675 3716403
SGTC_2253 7938677 135.83 µM 0.350138740176858 0.384778531985835 no 1262 0.363117289176446 1828 2301972
SGTC_844 0330-0132 15.3 µM 0.349825033431651 0.384887193832116 no 1263 0.363235005350178 1781 2828079
SGTC_1200 1643-0193 18.4 µM 0.349762501122248 0.384908854875218 no 1264 0.363258471688923 1787 5403974
SGTC_591 4299-0174 154 µM 0.347946808331159 0.385537962912776 no 1265 0.363940065529004 1736 5509088
SGTC_33 0986-0033 35.816 µM 0.347126716950313 0.385822210111162 no 1266 0.364248061381072 1725 2848082
SGTC_772 k072-0172 35.3 µM 0.34672646443644 0.385960961629209 no 1267 0.364398413208503 1604 5861980
SGTC_592 k241-0073 46.5 µM 0.339453697318667 0.388484663106044 no 1268 0.367133986320014 1813 4230158
SGTC_2377 9073351 62.6 µM 0.338529585864466 0.388805676113916 no 1269 0.367482067752767 1668 7337946 YHR072W ERG7
SGTC_2144 5628481 200 µM 0.338427861746838 0.388841017149867 no 1270 0.367520390435638 1729 2818399
SGTC_2948 9070189 9.45 µM 0.337991399226068 0.388992663581003 no 1271 0.367684834600821 1843 6473636 YDL196W YDL196W
SGTC_632 0781-2353 4.65 µM 0.332560346696024 0.390881059683486 no 1272 0.369733089929692 1776 6811515 YHR007C ERG11
SGTC_505 gw-5074 63.9 µM 0.331577460387476 0.391223089296627 no 1273 0.370104170796414 1805 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_127 0180-0333 59.125 µM 0.331293153793568 0.391322039403848 no 1274 0.370211531045603 1772 771601
SGTC_120 rhodamine 6G 52.259 µM 0.330553320539485 0.39157956402636 no 1275 0.37049095528005 1684 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2471 5466956 24.79 µM 0.33031368062338 0.391662989205118 no 1276 0.370581478443044 1770 724419
SGTC_2853 9015042 58.44 µM 0.326805705073082 0.392884779405137 no 1277 0.371907422071398 1656 6457456
SGTC_851 0394-0702 453 µM 0.325338496809205 0.393396106212506 no 1278 0.372462448989153 1863 762646
SGTC_1670 st016595 4.04 µM 0.325269887086086 0.393420021430268 no 1279 0.372488409701174 1798 597879
SGTC_1607 st000305 50.6 µM 0.323624884838595 0.393993538309035 no 1280 0.373111022828355 1814 5457690
SGTC_1881 5652484 16 µM 0.323332259081585 0.3940955840673 no 1281 0.373221812857779 1851 2255129
SGTC_2095 5432005 200 µM 0.322635989870362 0.394338419389792 no 1282 0.373485467074545 1728 783734
SGTC_1198 1612-1005 86.7 µM 0.32252595295459 0.394376800332222 no 1283 0.373527139853475 1839 6998509
SGTC_1155 4088-0394 48.2 µM 0.321957323470113 0.394575154973273 no 1284 0.373742512694473 1710 2326248
SGTC_113 0099-0221 2.5 µM 0.320051338645973 0.395240217480948 no 1285 0.374464706522532 1846 89219
SGTC_1689 st020265 53.493 µM 0.319758601483782 0.395342390459732 no 1286 0.374575666216471 1850 5758320 YPR016C TIF6
SGTC_2046 4110841 106 µM 0.318706628886445 0.395709615936581 no 1287 0.374974493734938 1868 44119630 YMR134W ERG29
SGTC_3015 9080845 49.47 µM 0.317644989402302 0.396080309839436 no 1288 0.37537712178264 1850 5296973
SGTC_2119 5528445 120.635 µM 0.31569091247127 0.396762862661238 no 1289 0.37611856251645 1841 791935
SGTC_1497 4476-2978 41.3 µM 0.315530335233512 0.396818965874468 no 1290 0.376179511153373 1784 1528379
SGTC_737 1950-0117 57.9 µM 0.315050183282505 0.396986736306566 no 1291 0.37636177586735 1868 5393513
SGTC_1052 3253-3998 198 µM 0.313091749932217 0.397671231872858 no 1292 0.377105478418643 1734 5450317
SGTC_1606 st000094 49.2 µM 0.31306288761151 0.39768132195627 no 1293 0.377116442117655 1913 1242210
SGTC_1447 4239-0816 81.9 µM 0.312457061472131 0.397893130702246 no 1294 0.377346595300212 1690 1341554
SGTC_926 2268-1401 59.4 µM 0.311542023872392 0.398213102906894 no 1295 0.377694300410055 1730 2931578
SGTC_630 4356-0227 183 µM 0.308938695811281 0.39912381370846 no 1296 0.378684080314957 1769 779312
SGTC_2171 5739187 198.077 µM 0.308930449006796 0.39912669952724 no 1297 0.378687217001407 1697 2262761
SGTC_512 prima-1 270 µM 0.307736106874799 0.399544695906423 no 1298 0.379141571398329 1841 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_402 epigallocatechin gallate 10 µM 0.307452868994274 0.399643840535626 no 1299 0.37924934593171 1735 65064 An antioxidant.
SGTC_1191 1487-1166 10.6 µM 0.307401192021053 0.399661930249137 no 1300 0.379269010492425 1836 3955771
SGTC_2268 7933382 153.85 µM 0.306493210889342 0.399979807470108 no 1301 0.379614574104334 1820 935025 YOR257W CDC31
SGTC_557 1315-0110 16.2 µM 0.304167205988085 0.400794425865767 no 1302 0.380500253858979 1724 6833801
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.300812132896236 0.401970206161525 no 1303 0.381778877983079 1773 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2969 9091408 28.7 µM 0.300804513066481 0.401972877533726 no 1304 0.381781783387717 1673 4286311
SGTC_1747 st037496 66.6 µM 0.300342397766357 0.402134895216797 no 1305 0.38195799818411 1761 723305
SGTC_1708 st033234 31.827 µM 0.299967546567602 0.402266330449203 no 1306 0.382100955214985 1865 674664
SGTC_1161 k007-0610 110 µM 0.299565954366064 0.402407154223138 no 1307 0.382254128300223 1849 5843850
SGTC_1500 4488-1866 171 µM 0.299559219258887 0.402409516088225 no 1308 0.382256697324885 1871 2900003
SGTC_1107 amlodipine 47 µM 0.299309696351987 0.402497021206305 no 1309 0.382351878453125 1753 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_3129 9127257 49.47 µM 0.297912801220828 0.4029869880826 no 1310 0.38288485868926 1664 837894
SGTC_36 0335-0881 14.2 µM 0.297800208986842 0.403026486930836 no 1311 0.382927827518907 1803 23828853
SGTC_1156 4092-0367 4.88 µM 0.296789247990211 0.403381189737206 no 1312 0.383313707344934 1801 1357585
SGTC_3212 9128307 49.47 µM 0.29436304832733 0.404232762833396 no 1313 0.384240249923161 1611 27243542
SGTC_1060 3448-7350 82 µM 0.293850024112337 0.404412887753908 no 1314 0.384436253944534 1901 570178
SGTC_1826 st055655 41.6 µM 0.292434240506884 0.404910080233352 no 1315 0.384977315837558 1797 676168
SGTC_2993 9054257 71.4286 µM 0.291653238701857 0.405184416883921 no 1316 0.385275882768405 1776 6470217 YGL055W OLE1
SGTC_2492 derrusnin 100 µM 0.291637772481935 0.405189850058019 no 1317 0.385281795992424 1769 1715307 Part of coumarin class of compounds.
SGTC_955 1216-0110 33 µM 0.291236130999188 0.405330950276958 no 1318 0.385435365543973 1722 3619719
SGTC_593 1203-0218 61.7 µM 0.290909683637426 0.405445643199492 no 1319 0.385560197497376 1897 3666956
SGTC_186 3455-3465 67.277 µM 0.289913469711962 0.405795699819104 no 1320 0.385941218312354 1817 755278
SGTC_782 0083-0095 30.5 µM 0.288248705205614 0.406380844442539 no 1321 0.386578184375564 1785 3591729 An indicator and reagent.
SGTC_3251 9135047 49.47 µM 0.286915576531351 0.406849573937665 no 1322 0.387088481677245 1904 17682963
SGTC_2817 7995342 71.43 µM 0.284482572117924 0.407705364564766 no 1323 0.388020293993049 1720 18879975
SGTC_747 3448-8087 38.7 µM 0.283766080088962 0.407957469300602 no 1324 0.388294825285659 1773 5168703
SGTC_1508 1080-0625 72.9 µM 0.283722405163505 0.407972837984209 no 1325 0.388311561589094 1834 767111
SGTC_2997 9067075 71.4286 µM 0.283229972075349 0.408146129087839 no 1326 0.388500277104672 1859 27209819
SGTC_1977 st070720 65.3 µM 0.283054584277603 0.408207853783896 no 1327 0.388567497466172 1798 682188
SGTC_793 0488-0545 106 µM 0.282919896508361 0.408255256356544 no 1328 0.388619121113873 1762 292548
SGTC_991 3996-0057 64.7 µM 0.282684249014752 0.408338194342718 no 1329 0.388709445725358 1807 715343
SGTC_1914 st062367 72.6 µM 0.282544285195891 0.408387457652039 no 1330 0.388763097256416 1772 978205
SGTC_563 tetrahydrosecaminediol 614 µM 0.282482136034587 0.408409332864916 no 1331 0.38878692121965 1931 334274 A psychoactive constituent of the cannabis plant.
SGTC_2753 fluvastatin 17.09 µM 0.280475764135202 0.409115687031016 no 1332 0.389556258490884 1826 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_922 1866-0035 480 µM 0.278398287668459 0.409847385039532 no 1333 0.390353316909522 1816 3156169
SGTC_471 1-acyl-paf 4 µM 0.277119634875887 0.410297889499848 no 1334 0.390844122783277 1751 16759367
SGTC_3032 9089427 49.47 µM 0.275695694534273 0.410799722075056 no 1335 0.391390901393713 1803 17173707
SGTC_2362 9071156 126 µM 0.274342308914896 0.411276824768107 no 1336 0.391910786724106 1882 653133
SGTC_1554 st069299 38.7 µM 0.273203088031801 0.41167853073918 no 1337 0.392348553171667 1875 24207999
SGTC_1680 diphenhydramine 100 µM 0.271158173859192 0.412399829433719 no 1338 0.393134690311798 1794 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2869 9037858 32.47 µM 0.270545036693009 0.412616157927906 no 1339 0.393370486973169 1809 27187042
SGTC_3264 9137442 49.47 µM 0.269745515925371 0.412898286588929 no 1340 0.393678020685449 1926 17015726
SGTC_2591 skatole 100 µM 0.268812809650071 0.413227469569566 no 1341 0.394036867692421 1827 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_151 3013-0144 2.285 µM 0.266047661124487 0.414203739905729 no 1342 0.395101251508673 1944 906558 YHR107C CDC12
SGTC_1682 st012968 530 nM 0.265033325508721 0.414561997087265 no 1343 0.395491894728266 1754 24207270
SGTC_1006 4099-6547 255 µM 0.264745984259689 0.414663497205373 no 1344 0.395602575345252 1899 3146833
SGTC_1849 st056239 19.2 µM 0.263705165324506 0.41503120263398 no 1345 0.396003557517293 1735 5393181
SGTC_2658 polymyxin b sulfate 77.05 µM 0.260568148327829 0.416139911885731 no 1346 0.397212777632394 1844 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1312 1218-2183 165 µM 0.260385348443673 0.416204539132215 no 1347 0.397283271760888 1929 6744073
SGTC_3074 9116018 49.47 µM 0.258943598958957 0.416714335896557 no 1348 0.397839378994391 1858 17027303
SGTC_1208 2323-2347 50.3 µM 0.257443226364624 0.41724501031063 no 1349 0.398418318628089 1991 5412760
SGTC_1716 st033144 30.6155 µM 0.257216356932954 0.417325266061528 no 1350 0.398505878850703 1970 674617
SGTC_3134 9127454 49.47 µM 0.256669157885904 0.41751885355441 no 1351 0.398717091256496 1912 24262820
SGTC_2286 7945697 125 µM 0.256243093923915 0.417669599853057 no 1352 0.398881567487597 1781 1245733
SGTC_1751 st044839 27.194 µM 0.253663798863521 0.418582441483618 no 1353 0.399877651880552 1967 5291326
SGTC_2777 climbazole 1.536 µM 0.251242262157394 0.419439849967776 no 1354 0.400813405852915 1908 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_52 0329-0193 875 nM 0.250629048713804 0.419657035125309 no 1355 0.401050460376251 1945 3739292
SGTC_786 4544-0069 423 µM 0.250259647172028 0.419787879905905 no 1356 0.401193280293576 1916 748821 YLR208W SEC13
SGTC_1942 st076330 65.2 µM 0.249815904709836 0.419945068517985 no 1357 0.401364859733934 1921 24208414
SGTC_1342 1486-1464 234 µM 0.249376900969885 0.420100591082243 no 1358 0.401534625596618 1845 3253938
SGTC_2587 piperic acid 92.2 µM 0.248479249205663 0.420418634257641 no 1359 0.401881811730395 1820 5370536
SGTC_1261 0712-0010 12.7 µM 0.247697037182839 0.420695818846497 no 1360 0.402184412217838 1965 2840123
SGTC_869 0564-0080 44.1 µM 0.247411151251941 0.420797135181472 no 1361 0.40229502247624 1813 6843321
SGTC_1258 0671-0043 57.1 µM 0.246442363589942 0.421140506948723 no 1362 0.402669907912175 1823 4298767
SGTC_165 k038-0023 64.381 µM 0.245864860959263 0.421345222359052 no 1363 0.402893422940137 1841 46368543
SGTC_89 0302-0250 142.109 µM 0.245784424865382 0.421373737351212 no 1364 0.402924557224196 1947 4203518 YLR208W SEC13
SGTC_2770 toltrazuril 17.5 µM 0.24494430287659 0.421671589360221 no 1365 0.403249778796078 1985 68591 Kills coccidiodes.
SGTC_2273 7815444 169.05 µM 0.244411660444679 0.421860452565093 no 1366 0.40345600592684 2004 2824616
SGTC_701 4424-0219 185 µM 0.244159445305745 0.4219498887381 no 1367 0.403553667307686 2002 2911779
SGTC_765 1319-0117 244 µM 0.243037587048062 0.422347751434039 no 1368 0.403988139979482 1816 3487746 YGL099W LSG1
SGTC_2420 aureobasidin a 50 nM 0.242768531011407 0.422443182914858 no 1369 0.404092357492723 1994 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2138 5575593 77.673 µM 0.240809689279307 0.423138101342252 no 1370 0.404851309811191 1838 762213
SGTC_2017 5132927 60.65 µM 0.240490058152143 0.423251516394569 no 1371 0.404975184797881 1835 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1467 k284-1082 293 µM 0.2387290547909 0.423876488888196 no 1372 0.405657842791282 1994 3334705
SGTC_1950 st077106 7.18 µM 0.237888469392076 0.42417487664184 no 1373 0.405983799461293 1841 13831864
SGTC_2413 inermin 26.06 µM 0.236921359375888 0.424518231382648 no 1374 0.406358899643534 2020 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2671 danthron 100 µM 0.235213843573489 0.425124593376657 no 1375 0.407021380884509 1893 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1206 3978-0017 132 µM 0.234941523439282 0.425221314364112 no 1376 0.407127060185252 1942 3873677
SGTC_2382 9035899 200 µM 0.23398934497827 0.425559538589121 no 1377 0.407496625277322 1858 6462679
SGTC_1392 3455-1037 33.9 µM 0.23324198088055 0.425825048895784 no 1378 0.407786754316145 1961 981132
SGTC_2793 7325131 81.82 µM 0.233200530754488 0.425839775549428 no 1379 0.407802846864223 1911 4176441
SGTC_2812 7970281 58.44 µM 0.232887899223901 0.425950852517553 no 1380 0.40792422757041 1972 2233435
SGTC_24 0417-1663 219 µM 0.232835401583474 0.425969505335206 no 1381 0.407944610900552 1871 4329390
SGTC_2376 9072922 81.32 µM 0.231991441601094 0.426269393551475 no 1382 0.40827233055101 1936 17087968
SGTC_1838 st055369 84.5 µM 0.230612385562583 0.426759511615753 no 1383 0.408807972331792 1982 676036
SGTC_2836 9010338 19.48 µM 0.2305945012083 0.426765868479882 no 1384 0.408814919949056 1755 2994051
SGTC_703 3875-0075 71.8 µM 0.22880738707974 0.427401180895024 no 1385 0.409509312515305 1918 2850814
SGTC_2565 isoliquiritigenin 100 µM 0.228561611120623 0.427488568099769 no 1386 0.409604832314748 1750 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2274 7947094 46.08 µM 0.22806124292017 0.427666488184336 no 1387 0.409799314901614 2029 2971028
SGTC_1573 oleylamine 1.06 µM 0.227969877827165 0.427698977219996 no 1388 0.40983482898772 1863 5356789 An amine of the fatty acid oleic acid.
SGTC_1507 4075-3230 155 µM 0.227228775779876 0.427962528030508 no 1389 0.410122926512283 2034 659771
SGTC_748 act1.228 77.9 µM 0.225452545443147 0.428594321917397 no 1390 0.410813619141103 1837 4421505 YNR035C ARC35
SGTC_2788 5282734 71.43 µM 0.225184781068618 0.428689579926168 no 1391 0.410917764187901 1996 743706
SGTC_925 2064-1272 59.6 µM 0.224126528919262 0.429066097020304 no 1392 0.411329425211018 1841 6815817
SGTC_2540 epiandrosterone 100 µM 0.223501270385971 0.429288589036486 no 1393 0.411572697254575 2039 441302 A steroid.
SGTC_597 k018-0003 82.8 µM 0.220951228246353 0.43019622803166 no 1394 0.412565204308379 1991 6786234
SGTC_252 miconazole 1.30953 nM 0.220705206592191 0.430283814351523 no 1395 0.412660988577942 1980 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1374 2889-5571 141 µM 0.219995768020261 0.430536401205432 no 1396 0.41293722530137 1886 2853281
SGTC_818 4072-2707 53.5 µM 0.218895697553633 0.430928123898232 no 1397 0.413365649027982 1901 882871
SGTC_1045 1348-1485 165 µM 0.217971664828084 0.431257214071453 no 1398 0.413725594403279 2012 6810614
SGTC_900 1112-0045 141 µM 0.21778905881307 0.431322254052109 no 1399 0.4137967348786 2022 56211 YIL048W NEO1
SGTC_2120 5538279 151.968 µM 0.217213722929721 0.431527187371383 no 1400 0.414020895317675 1927 2058197
SGTC_1761 st044296 37 µM 0.216742858229961 0.431694922013074 no 1401 0.414204372893933 1918 1826700
SGTC_261 5-fluorouridine 15.376 µM 0.216614298215983 0.431740720681608 no 1402 0.414254470964372 2010 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1857 st056007 79.3 µM 0.216211132775 0.431884351694396 no 1403 0.414411588039651 2027 619834
SGTC_1969 st069479 40.1 µM 0.216073055530325 0.431933544922393 no 1404 0.414465401091447 2012 3895485
SGTC_2785 7756463 72.73 µM 0.21554659602504 0.432121118036065 no 1405 0.414670593666956 1890 2201551
SGTC_2987 9018338 71.43 µM 0.214257099984995 0.432580619235731 no 1406 0.415173285212753 1972 5055682
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.212548293991246 0.433189678448529 no 1407 0.415839652600344 1982 4000243
SGTC_2402 5553605 200 µM 0.212292268019213 0.43328094591841 no 1408 0.415939513595335 1985 6758546
SGTC_2347 9049783 174.81 µM 0.208938145257055 0.434476941727777 no 1409 0.417248262832916 1991 6467988 YPL169C MEX67
SGTC_2094 5332512 191.667 µM 0.208855466590308 0.434506430481698 no 1410 0.417280534967063 2022 755774
SGTC_1413 3910-0535 34.4 µM 0.208478068776511 0.434641040461794 no 1411 0.417427852506795 2023 2876951
SGTC_3198 9112019 49.47 µM 0.206913607706207 0.435199131945145 no 1412 0.418038664536559 1945 45595555
SGTC_190 3970-0790 3.722 µM 0.206192835969245 0.435456296950742 no 1413 0.418320141841999 2041 2832352
SGTC_74 000s-0487 160.283 µM 0.205315418626949 0.43576938856075 no 1414 0.418662849169289 2085 677548
SGTC_2674 ligustilide 100 µM 0.205215642961088 0.43580499438078 no 1415 0.418701824107199 1962 5319022 A signalling regulator.
SGTC_2556 citropten 84.59 µM 0.205096498960067 0.435847512642442 no 1416 0.418748365859732 1863 2775 A potential DNA crosslinker.
SGTC_1748 st037455 53.6035 µM 0.204769471993069 0.435964220759434 no 1417 0.418876119705647 1953 580690
SGTC_2177 5811945 192 µM 0.203416760550474 0.436447030304831 no 1418 0.419404650318047 2017 5343475
SGTC_3002 9075603 71.4286 µM 0.203265504653089 0.436501022434516 no 1419 0.419463757990936 2056 20105405
SGTC_386 1509-0011 3.07 µM 0.202403808561525 0.436808635010689 no 1420 0.41980052560995 1932 3107280
SGTC_3178 9107506 49.47 µM 0.202182474949007 0.436887653965266 no 1421 0.419887036588836 1993 8897194
SGTC_1956 st077085 54 µM 0.202141459320163 0.436902297350456 no 1422 0.419903068479766 1912 24208685
SGTC_1658 st012944 20 µM 0.200742342682827 0.437401861116686 no 1423 0.420450024453237 2018 24207260
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.199711134474554 0.43777012470581 no 1424 0.420853252575645 1948 5379071
SGTC_1223 0764-0573 147 µM 0.199615541669902 0.437804265405535 no 1425 0.420890635958396 1969 1609797
SGTC_2612 dictamnine 15.46 µM 0.199321628361363 0.437909238611298 no 1426 0.421005580809771 1950 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2940 9060638 45.86 µM 0.199266311010563 0.437928996081103 no 1427 0.421027215304963 1940 4027022
SGTC_2107 5363541 170.161 µM 0.199258470654117 0.437931796401367 no 1428 0.421030281670558 2046 244052
SGTC_226 1,3-diallylurea 8.28947 mM 0.1991786412246 0.437960309053539 no 1429 0.421061503255399 1997 74537 YKL182W FAS1
SGTC_984 1492-0255 2.91 µM 0.198712552658092 0.438126788185416 no 1430 0.42124380212042 1959 1585198
SGTC_2395 5646831 180.19 µM 0.198703360558767 0.438130071561568 no 1431 0.421247397549673 1989 6808628
SGTC_1928 4'-methoxychalcone 40.3 µM 0.197985723982062 0.438386421217454 no 1432 0.421528116627934 2102 641818
SGTC_2139 5578692 56.4705 µM 0.19690575919793 0.438772248188151 no 1433 0.421950643362535 2086 650991 YMR113W FOL3
SGTC_1460 k062-0059 9.15 µM 0.196096557361992 0.439061380856024 no 1434 0.422267295388824 1913 1373085
SGTC_429 1112-0049 25.5 µM 0.194930956841042 0.4394779140264 no 1435 0.422723499489947 1876 2836170
SGTC_2499 avocadenofuran 51.48 µM 0.193545778016408 0.439973001705116 no 1436 0.423265779040131 1858 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_97 0535-0701 19.132 µM 0.192140833943715 0.440475249732645 no 1437 0.423815944952914 1941 2832013 YGL099W LSG1
SGTC_1059 3448-6867 171 µM 0.191801716390222 0.440596493936593 no 1438 0.42394876322116 2115 3934407
SGTC_3235 9132602 49.47 µM 0.189221385838261 0.441519217352891 no 1439 0.42495965347851 1994 4912240
SGTC_646 4092-0839 27.3 µM 0.188766924059341 0.44168176541909 no 1440 0.425137748258154 2039 877796
SGTC_1027 k015-0025 8.67 µM 0.187601124831122 0.442098783530663 no 1441 0.425594672206586 1929 3598955
SGTC_651 3253-0966 34.4 µM 0.185261095918836 0.442936028645871 no 1442 0.426512125370449 1971 781462
SGTC_2210 7115885 190.385 µM 0.185071585443185 0.443003845305071 no 1443 0.426586444061497 1985 2927039
SGTC_2121 5257820 149.641 µM 0.18300740629011 0.44374262319461 no 1444 0.427396103691158 2109 791256
SGTC_2594 a-mangostin 100 µM 0.182724887420852 0.443843753088082 no 1445 0.427506943588293 2066 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_417 st075190 100 µM 0.18255632119425 0.443904094462196 no 1446 0.427573079466028 2101 222757
SGTC_1000 4048-0884 8.67 µM 0.182365749765869 0.443972314568266 no 1447 0.427647851394521 2000 13040088
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.18235176524222 0.44397732076547 no 1448 0.427653338414906 1904 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_167 3672-0051 66.205 µM 0.182292372688217 0.443998582285561 no 1449 0.427676642057043 1999 3237971
SGTC_1845 st056753 3.01 µM 0.181861741884529 0.444152745576701 no 1450 0.427845614653556 1905 5375839
SGTC_78 0336-0123 156.75 µM 0.181565462241353 0.444258816852184 no 1451 0.427961877703468 1882 6765896
SGTC_1659 st012954 42.1 µM 0.181436903730957 0.444304843413971 no 1452 0.428012327275358 2035 24207262
SGTC_2912 7964298 10.93 µM 0.181252955505672 0.444370701926479 no 1453 0.428084515201746 1959 2975850
SGTC_535 2293-4129 48.2 µM 0.180980517531797 0.444468245018792 no 1454 0.428191434122479 2084 396118 YIL048W NEO1
SGTC_1005 4092-0690 4.4 µM 0.17795558467498 0.44555150999033 no 1455 0.429378928595094 1949 1529343
SGTC_3263 9137018 49.47 µM 0.177681556380918 0.445649663037929 no 1456 0.429486535315794 1887 43844957
SGTC_1139 k015-0024 46.9 µM 0.177563613102759 0.445691909672839 no 1457 0.429532851450875 2110 2766652
SGTC_2074 5212007 75.395 µM 0.177319310199877 0.445779419592767 no 1458 0.429628791891509 2121 758611
SGTC_149 3970-0822 46.1 µM 0.176763965630603 0.445978355247564 no 1459 0.429846897273629 1978 3114250 YBL034C STU1
SGTC_1692 fluoroquinolonic acid 71 µM 0.176482418611903 0.446079216281429 no 1460 0.42995747990651 2047 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_115 0527-0192 112.043 µM 0.175647751019963 0.446378246981935 no 1461 0.430285342806683 1965 4233931
SGTC_455 paf C-16 10 µM 0.175025577996472 0.446601168542215 no 1462 0.430529767731322 2007 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_656 4090-1979 187 µM 0.174894471629678 0.446648145469178 no 1463 0.430581277162211 2102 22330961
SGTC_2096 5468907 200 µM 0.174289134438112 0.446865054482084 no 1464 0.430819119009918 2098 759785
SGTC_334 1502-1024 68.5 µM 0.173996701864218 0.446969846838307 no 1465 0.430934027113412 2006 3296216
SGTC_1379 2144-0755 36.5 µM 0.173358161177023 0.447198678882789 no 1466 0.431184954831458 2109 5392327
SGTC_516 3992-2719 87.3 µM 0.173046689305728 0.447310306571644 no 1467 0.431307364205952 1908 5350887 YDR037W KRS1
SGTC_3274 9138298 49.47 µM 0.170702549273171 0.448150550839632 no 1468 0.43222882911118 2114 17015756
SGTC_1984 st072354 53.1 µM 0.169215719190576 0.448683617845614 no 1469 0.432813482980078 2014 5762938
SGTC_696 1560-0013 611 µM 0.166709918879824 0.449582221191184 no 1470 0.433799150311972 2069 1650269
SGTC_3353 9151644 39.2805 µM 0.164935961589244 0.450218535432461 no 1471 0.434497193379994 2018 4909158
SGTC_43 0570-0105 72.5 µM 0.163426447696825 0.450760095322619 no 1472 0.435091340278614 2041 1114046 YDL195W SEC31
SGTC_1560 lithocholic acid 53.1 µM 0.163096536238149 0.450878468062184 no 1473 0.435221213482065 2124 9903 A bile acid which acts as a detergent.
SGTC_1215 3852-0577 11.2 µM 0.162957983399959 0.450928182337267 no 1474 0.435275758385482 2091 2884876
SGTC_3020 9089140 49.47 µM 0.162875045212894 0.450957941835087 no 1475 0.435308409734336 1999 17217859
SGTC_2684 capsaicin 100 µM 0.162864949812093 0.450961564239072 no 1476 0.435312384151463 2041 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.161809343955506 0.451340356316699 no 1477 0.435727997301447 1932 23665772 A membrane-active detergent.
SGTC_2711 st079103 59.1 µM 0.160591406067273 0.451777454422297 no 1478 0.436207612003846 2097 54693780
SGTC_1026 k007-1105 30.6 µM 0.16041254553865 0.451841649493876 no 1479 0.436278053840394 1969 7066794
SGTC_2815 7968870 71.43 µM 0.160322423676971 0.451873995728991 no 1480 0.436313547900962 2025 2977326 YHR190W ERG9
SGTC_1097 itavastatin 7.23 µM 0.159670628641365 0.452107945306027 no 1481 0.436570269481975 2040 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2512 diallyl trisulfide 49.23 µM 0.158971215092798 0.452359005148658 no 1482 0.436845776214287 2145 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_3189 9110682 49.47 µM 0.158722566159324 0.452448264180326 no 1483 0.436943729167372 1996 17122418
SGTC_1666 st014829 29 µM 0.158275507728119 0.452608753527297 no 1484 0.437119853431304 2028 3858230
SGTC_2040 5100729 123 µM 0.157962022905758 0.452721295951801 no 1485 0.437243362135908 2049 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2669 eugenol 100 µM 0.157892684305197 0.452746189326432 no 1486 0.43727068141645 2144 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.157182958893552 0.45300099977438 no 1487 0.43755032909355 1910 641818 YHR062C RPP1
SGTC_770 0389-1121 67.2 µM 0.155859282476221 0.453476286720113 no 1488 0.438071970438872 2120 6753108
SGTC_2173 5763948 167 µM 0.155623712738307 0.453560878764278 no 1489 0.438164816304014 2131 2867177
SGTC_1028 k015-0029 4.8 µM 0.154786113738581 0.453861673875085 no 1490 0.438494969448517 2123 4588309
SGTC_1168 k815-0004 80.5 µM 0.154755225599893 0.453872766803586 no 1491 0.438507145325961 2033 642433
SGTC_2302 7771753 200 µM 0.154589103752766 0.453932427142735 no 1492 0.438572630336148 1981 2203047
SGTC_2050 5263056 171 µM 0.153958055877461 0.454159068628877 no 1493 0.43882140387837 2133 763468 YGL055W OLE1
SGTC_1825 st052143 62.6 µM 0.153723129680586 0.454243446428247 no 1494 0.438914023351222 2125 674173
SGTC_1195 1502-0147 41.1 µM 0.151870067633491 0.454909077735132 no 1495 0.439644708487749 2065 817940
SGTC_2736 butenafine 14.65 µM 0.151819623787356 0.454927199254386 no 1496 0.439664602002725 2116 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3158 9100007 49.47 µM 0.151232885840462 0.455137986712405 no 1497 0.439896004739611 2000 19297233
SGTC_299 1273-0059 1.44 µM 0.150201660462172 0.455508488255425 no 1498 0.440302757949266 2140 2848077
SGTC_690 glyoxal 20.3 µM 0.149224995891367 0.455859422725601 no 1499 0.440688048472313 2073 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1973 st070275 50.2 µM 0.148380170033051 0.456163012787072 no 1500 0.441021374427174 2166 17118334
SGTC_2662 daunorubicin 22.37 µM 0.147849285414085 0.456353800468225 no 1501 0.441230856293055 2113 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1216 1165-0504 9.65 µM 0.147189545483367 0.456590909793146 no 1502 0.441491206109111 2160 6304004
SGTC_1910 st062352 60.4 µM 0.14617293253239 0.456956308859774 no 1503 0.441892436368783 2074 2245730
SGTC_184 1494-0393 24.714 µM 0.143979968561393 0.457744644843818 no 1504 0.442758143790763 2029 3090647
SGTC_3081 9117243 49.47 µM 0.143139159778953 0.458046946615305 no 1505 0.443090139162597 2140 45595589
SGTC_1501 4491-0275 38.4 µM 0.143082173471412 0.458067436175029 no 1506 0.443112641791795 2170 5104718
SGTC_1634 st006576 41 µM 0.139872601114899 0.459221623665804 no 1507 0.444380324794131 2167 3915356
SGTC_2780 5215298 71.43 µM 0.139822366119774 0.459239691323552 no 1508 0.444400170639923 2192 2834131
SGTC_118 0083-0097 135.343 µM 0.138297165071962 0.459788289273327 no 1509 0.445002782963717 2061 5207356
SGTC_358 0075-0058 9.45 µM 0.137026101332498 0.460245535382165 no 1510 0.445505081912087 2242 1069125
SGTC_96 0929-0093 37.281 µM 0.136583387673724 0.460404807354551 no 1511 0.445680054073272 2026 6991579
SGTC_556 4058-0063 51.5 µM 0.135318877823623 0.460859766051198 no 1512 0.446179880005345 2065 6615692
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.135312963618452 0.460861894047183 no 1513 0.446182217929402 2032 442882
SGTC_2196 6573537 42.6665 µM 0.134833264643098 0.461034498734478 no 1514 0.446371852300736 2181 2903087
SGTC_2364 9055074 200 µM 0.133770851170173 0.46141680111269 no 1515 0.446791888694553 2048 6470630
SGTC_491 tetrandrine 80.3 µM 0.132550155821126 0.461856104164799 no 1516 0.44727457717597 2160 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2873 9040596 71.43 µM 0.132108917556266 0.462014908185727 no 1517 0.447449071273907 1999 6463863
SGTC_1347 1493-0251 600 nM 0.132078589868477 0.462025823506124 no 1518 0.447461065173707 2162 3986378
SGTC_296 1222-0039 74.9 µM 0.131903107203357 0.462088982509512 no 1519 0.447530465456149 2062 5984176
SGTC_1867 st057372 64 µM 0.131834705330369 0.46211360169101 no 1520 0.447557517619267 2169 688837
SGTC_938 3126-1755 342 µM 0.131384729167544 0.46227556058977 no 1521 0.447735484151158 2186 1777771
SGTC_2256 7954252 200 µM 0.129120725264115 0.463090532738115 no 1522 0.44863106144718 2052 2972920
SGTC_193 1273-0060 1.558 µM 0.127903411436853 0.463528792746505 no 1523 0.449112705643488 2168 2847393 YHR072W ERG7
SGTC_1394 3474-0001 65.7 µM 0.127652471826569 0.463619142098741 no 1524 0.449212002128895 2080 5017666 YIL048W NEO1
SGTC_889 0919-1524 82.7 µM 0.127479132000658 0.463681553194402 no 1525 0.449280594335918 2032 3905452
SGTC_389 tpck 16.7 µM 0.124705192584652 0.464680432103699 no 1526 0.450378473203785 2084 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_204 PMA1.184 62.41 µM 0.124673855748568 0.464691717593541 no 1527 0.450390877985312 2192 2252213 YGL008C PMA1
SGTC_2687 chenodiol 100 µM 0.124005214555875 0.464932525409052 no 1528 0.450655573157672 2109 5702181 A cholesterol synthesis inhibitor.
SGTC_3008 9078912 71.4286 µM 0.123880302301546 0.464977513365544 no 1529 0.45070502464267 2087 16648731
SGTC_2515 chrysin 20.77 µM 0.122284359025498 0.465552341862133 no 1530 0.451336909360032 2150 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_3192 9110362 49.47 µM 0.122066903161644 0.465630670930849 no 1531 0.451423016637178 2168 16649480
SGTC_194 1486-1323 56.904 µM 0.122029656447285 0.465644087582212 no 1532 0.45143776566708 2055 5178754
SGTC_2721 ifenprodil 61.44 µM 0.12187818892794 0.465698648149847 no 1533 0.45149774477465 2168 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2128 5255449 168.493 µM 0.121845713141853 0.465710346433747 no 1534 0.451510604894873 2145 736008
SGTC_2957 9076800 11.52 µM 0.121751887063955 0.465744144214603 no 1535 0.451547759466639 2087 16459615
SGTC_2439 5492030 7.2 µM 0.121667262289275 0.465774627738353 no 1536 0.451581270740818 2204 5722370
SGTC_686 1319-0111 510 µM 0.121563349612612 0.465812059421955 no 1537 0.451622420464986 2180 4562600
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.1214049610811 0.465869115115639 no 1538 0.451685143787002 2153 616764
SGTC_1188 1403-0014 4.57 µM 0.121277346024263 0.465915085908864 no 1539 0.45173568140615 2068 9614867
SGTC_2841 9004761 38.96 µM 0.120979984295243 0.466022206337689 no 1540 0.451853444476425 1980 2991039
SGTC_1108 betulinic acid 729.144 nM 0.118659811792892 0.466858100161182 no 1541 0.452772438535783 2084 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_3229 9132204 49.47 µM 0.117368749326319 0.467323297716669 no 1542 0.45328392365318 2111 17682924
SGTC_2136 5328288 199.296 µM 0.11531516956086 0.468063338351109 no 1543 0.45409765750079 2106 262395
SGTC_2412 st077135 33.4 µM 0.114647010067608 0.468304144339055 no 1544 0.454362458349809 2151 13258915
SGTC_10 0279-0212 42.575 µM 0.113930320490195 0.468562453553636 no 1545 0.45464651488803 2196 39851 YBR002C RER2
SGTC_2424 5537928 59.2 µM 0.113824344246973 0.468600650630721 no 1546 0.454688520044816 2101 5382802
SGTC_329 k048-0121 21.3 µM 0.113448081336323 0.468736269616209 no 1547 0.45483766116843 2100 6832902
SGTC_1964 st076914 61 µM 0.113437583683849 0.468740053408177 no 1548 0.454841822264371 2215 24208661
SGTC_2375 9072683 200 µM 0.111924251874285 0.469285550709882 no 1549 0.455441733601856 2219 16798029
SGTC_1449 4112-4002 201 µM 0.110375334978289 0.469843934753452 no 1550 0.456055856715369 2040 2059539
SGTC_541 4513-1321 94 µM 0.11035139064041 0.469852567147898 no 1551 0.456065351126395 2026 747515
SGTC_31 0508-1974 57.237 µM 0.110117700887557 0.469936817542872 no 1552 0.456158015124775 2187 6810525
SGTC_2261 9010538 184.68 µM 0.109840712778613 0.470036679708677 no 1553 0.45626785112299 2058 6457250
SGTC_1604 st002052 72.4 µM 0.109808119820604 0.470048430529853 no 1554 0.456280775652505 2125 6254834 YHR062C RPP1
SGTC_1035 k081-0041 55.2 µM 0.109144936765418 0.470287535236435 no 1555 0.456543766688251 2227 731709
SGTC_2569 tetrandrine 100 µM 0.108672419091759 0.470457903789563 no 1556 0.456731159321427 2028 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_382 3229-0966 23.2 µM 0.107445697177473 0.47090022952788 no 1557 0.457217701601807 2203 5722370
SGTC_1102 cgs 12066b 26.1 µM 0.10557395563288 0.471575202473692 no 1558 0.457960194818327 2134 6438352 A 5-HT1B full agonist.
SGTC_674 0498-0004 451 µM 0.104946735290576 0.471801404179302 no 1559 0.458209037148178 2076 4231473
SGTC_943 3253-1379 105 µM 0.104401470091998 0.47199805684996 no 1560 0.458425378047216 2178 668464
SGTC_1226 3909-7979 35.4 µM 0.104258470375892 0.472049631557696 no 1561 0.458482117043506 2204 6615510
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.104048166267465 0.472125481321223 no 1562 0.458565562410203 2194 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1821 st053465 65.6 µM 0.103602624364596 0.47228617694352 no 1563 0.458742352465944 2132 675086
SGTC_1245 0418-0076 17.2 µM 0.102881784322543 0.472546175138672 no 1564 0.459028397490225 2123 6790114
SGTC_652 0437-0092 114 µM 0.102480091316083 0.472691065980615 no 1565 0.459187807235864 2192 3091274
SGTC_551 k048-0028 34.9 µM 0.10054616772265 0.473388683298403 no 1566 0.459955365985317 2210 6836383
SGTC_970 1315-0089 19.5 µM 0.0997042760985057 0.473692401469396 no 1567 0.460289552813052 2226 6811083 YLR033W RSC58
SGTC_1247 0448-0043 5.84 µM 0.0962825123381924 0.474926981725823 no 1568 0.461648099843254 2133 3089013 YGL099W LSG1
SGTC_449 xestospongin c 11.1929 µM 0.0951536396880204 0.475334334986434 no 1569 0.462096396502081 2181 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2371 9071574 200 µM 0.0950188873053069 0.47538296206272 no 1570 0.462149912447751 2232 45596039
SGTC_1909 st060837 51.5 µM 0.0947974236162637 0.475462880790474 no 1571 0.462237866657012 2145 678937
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.0932752568596752 0.476012205643454 no 1572 0.462842444268278 2145 4330530
SGTC_2832 7992762 51.95 µM 0.093067628054199 0.476087139008633 no 1573 0.462924917427904 2037 2985177
SGTC_726 3448-4391 34.2 µM 0.0924485894997636 0.476310555417413 no 1574 0.463170817925642 2187 1356692
SGTC_130 0136-0219 337.655 µM 0.0918011033531514 0.476544246777529 no 1575 0.46342803370833 2267 234244
SGTC_255 tunicamycin 200.472 nM 0.0916378959612107 0.47660315303199 no 1576 0.463492870743315 2241 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2702 st077768 96.8 µM 0.09152937468341 0.476642321773864 no 1577 0.463535983285109 2144 6484119
SGTC_1270 0831-1170 17.3 µM 0.0913840347976107 0.476694779862662 no 1578 0.463593723525696 2233 6764716
SGTC_398 bronopol 33.3 µM 0.0913649198950494 0.476701679108667 no 1579 0.463601317500081 2139 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_176 1486-1328 72.834 µM 0.0907801714920957 0.476912738902902 no 1580 0.463833632921341 2171 22310231
SGTC_775 4577-0580 57.3 µM 0.0903396873777823 0.477071732050833 no 1581 0.464008641551909 2198 2006902
SGTC_3288 9119690 36.221 µM 0.0899388784846098 0.477216407563238 no 1582 0.464167892883025 2151 17595618 YKL019W RAM2
SGTC_3327 9140648 26.9345 µM 0.089822682177787 0.477258350209463 no 1583 0.464214061637069 2220 8029710
SGTC_2067 5224629 34.075 µM 0.0886916811248268 0.477666613597876 no 1584 0.464663471990936 2145 2835000
SGTC_1653 st012112 65 µM 0.0886739231793299 0.477673023964721 no 1585 0.464670528582802 2228 720429
SGTC_1787 fluconazole 80 µM 0.0884313743391157 0.47776058123878 no 1586 0.464766912925821 2181 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1780 st038448 24.544 µM 0.0883389397638068 0.477793949314307 no 1587 0.464803645230294 2203 728868 YDL195W SEC31
SGTC_1082 camptothecin 424.86 nM 0.0880491475848468 0.47789856277151 no 1588 0.464918806836178 2248 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1836 st055642 81 µM 0.0854614652622903 0.478832769193008 no 1589 0.465947264809562 2186 8571
SGTC_1285 0929-0069 65.5 µM 0.0853359518934546 0.47887808509366 no 1590 0.465997155143429 2175 1206237
SGTC_2312 7706453 155.7 µM 0.0841221358964352 0.479316340579674 no 1591 0.466479662560587 2185 976098
SGTC_2418 pentamidine 31.67 µM 0.0840987822389668 0.479324772803512 no 1592 0.466488946424135 2264 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2001 4023502 57.655 µM 0.0840653381432749 0.479336848362881 no 1593 0.466502241607676 2204 108941 YCR052W RSC6
SGTC_1018 4259-0013 28.1 µM 0.0839538954456286 0.479377086780455 no 1594 0.466546544200086 2174 6801262
SGTC_479 n-linoleoylglycine 10 µM 0.0820235817265108 0.480074094734084 no 1595 0.467313980565644 2153 6433346 An anti-infammatory.
SGTC_779 1360-0071 233 µM 0.0819120754396046 0.480114359899687 no 1596 0.467358315948927 2280 7566
SGTC_1923 st058458 19.1 µM 0.0815269461195146 0.480253432502864 no 1597 0.46751144814817 2289 3534982
SGTC_1456 k015-0012 13 µM 0.0810230382965115 0.480435400392707 no 1598 0.467711815412573 2278 2989616
SGTC_804 1595-0054 20.9 µM 0.0798428869727277 0.480861584791859 no 1599 0.468181107155468 2127 761523 Stimulates phospholipase C.
SGTC_1023 4482-3888 16 µM 0.0793128409132712 0.481053005834845 no 1600 0.468391896452936 2261 3303168
SGTC_2244 6635614 200 µM 0.0786527398065885 0.481291401112097 no 1601 0.468654418567226 2112 836499
SGTC_1171 0368-0077 21.4 µM 0.0781934493412027 0.481457277650722 no 1602 0.468837086366613 2201 3239779
SGTC_2249 haloperidol 116.36 µM 0.0771269427480788 0.481842467634531 no 1603 0.469261279810417 2204 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2927 9011802 47.9 µM 0.0748175757834037 0.482676598878288 no 1604 0.470179928779142 2165 43912568
SGTC_2868 9035608 32.47 µM 0.0746930861515235 0.482721566067688 no 1605 0.470229454379793 2275 6462614
SGTC_3148 9097893 49.47 µM 0.074485893652551 0.482796407039062 no 1606 0.470311882609921 2200 17174100
SGTC_921 1561-0023 372 µM 0.0743499917644372 0.482845497124917 no 1607 0.470365949698979 2301 24050882
SGTC_667 1498-1044 59 µM 0.0734357848751299 0.483175731008014 no 1608 0.470729671122431 2200 6739982
SGTC_3 0833-0587 95.581 µM 0.0721310197245244 0.483647064021356 no 1609 0.471248820171351 2201 5382644
SGTC_614 0462-0418 107 µM 0.0717262459701609 0.483793289059119 no 1610 0.471409884344363 2243 5188303
SGTC_1127 asiatic acid 681.4 nM 0.0710617610524045 0.484033339804791 no 1611 0.471674300729582 2212 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2754 granisetron 64.02 µM 0.070798812936698 0.48412833361841 no 1612 0.47177893829751 2266 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_3304 9125678 46.087 µM 0.0700934366553276 0.484383165446855 no 1613 0.472059645322794 2243 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_881 0833-0569 170 µM 0.0685455285398614 0.484942401607587 no 1614 0.47267568937085 2113 5418700
SGTC_3346 9158254 43.5805 µM 0.067993841499739 0.485141725139323 no 1615 0.472895268355869 2215 17639500
SGTC_2225 6654152 15.4 µM 0.0675931308546145 0.485286503502526 no 1616 0.473054761839332 2275 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2835 9006588 71.43 µM 0.0669037157062864 0.485535596489006 no 1617 0.473329177481418 2140 2345538
SGTC_100 0086-0128 49.5915 µM 0.0665292988652735 0.485670879625852 no 1618 0.473478216127164 2238 93297
SGTC_817 1391-0715 46 µM 0.0662594442469082 0.485768383686825 no 1619 0.473585635518792 2211 1353946
SGTC_2385 9074692 200 µM 0.0652423846252505 0.486135875984524 no 1620 0.473990507471867 2144 17046906
SGTC_805 3852-0218 479 µM 0.0649158299013257 0.486253871919288 no 1621 0.474120508370068 2273 6615355
SGTC_1782 st039423 80.636 µM 0.0647871218302782 0.486300379093139 no 1622 0.474171747599263 2134 2068169
SGTC_545 4218-0007 221 µM 0.0645364987153905 0.486390939393051 no 1623 0.474271522949952 2228 2840508
SGTC_1128 3448-9350 235 µM 0.0628773539194619 0.486990473205374 no 1624 0.474932084054175 2133 619386
SGTC_3047 9092122 49.47 µM 0.0626453346722239 0.487074315992096 no 1625 0.475024464220168 2251 17173831
SGTC_399 oxolinic acid 75 µM 0.0611522849786175 0.487613859940682 no 1626 0.475618964819538 2175 4628 A DNA gyrase inhibitor.
SGTC_2876 9059903 25.97 µM 0.0589744718696185 0.488400897492069 no 1627 0.476486220604631 2296 6916095
SGTC_966 1300-0360 30.2 µM 0.0582680701211333 0.488656193115267 no 1628 0.47676755031946 2267 70588
SGTC_2384 9036245 200 µM 0.0581231249716252 0.488708577287225 no 1629 0.476825277232411 2259 6462766
SGTC_1009 4106-0057 9.87 µM 0.0578765834744882 0.488797679523542 no 1630 0.476923467764626 2323 2928005
SGTC_1063 disulfiram 1.84 µM 0.0577994279001136 0.488825564332679 no 1631 0.476954196944235 2306 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_850 0388-0143 75.9 µM 0.0575124008866412 0.488929299292466 no 1632 0.477068513990524 2230 67273
SGTC_1995 st072814 61.1 µM 0.0573224057502401 0.488997966195833 no 1633 0.477144186243967 2153 5769371
SGTC_3255 9139072 49.47 µM 0.0570291504877426 0.489103953394446 no 1634 0.477260987095539 2217 17646060
SGTC_2315 7733312 200 µM 0.0563637558146994 0.489344440641489 no 1635 0.477526014852146 2267 726316
SGTC_80 0159-0065 512.242 µM 0.0555417201145894 0.489641546499948 no 1636 0.477853446691462 2301 1548079
SGTC_2850 9015429 58.44 µM 0.0550275343657122 0.48982739002102 no 1637 0.47805826388452 2266 6457570
SGTC_654 1124-0271 80.9 µM 0.0538697759354569 0.490245849749095 no 1638 0.478519458498478 2260 5403748
SGTC_1219 1469-0211 33.1 µM 0.0530262098415399 0.490550754716655 no 1639 0.47885551232628 2317 6822282
SGTC_470 aa-861 153 µM 0.052368595969787 0.490788451532937 no 1640 0.479117498276897 2274 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1429 4049-0205 9.46 µM 0.0512488688931848 0.491193188252607 no 1641 0.479563605616717 2291 22774478
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.0510124759491332 0.491278636055416 no 1642 0.479657789561474 2201 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2400 5203494 178.7 µM 0.0492401942808142 0.491919266531038 no 1643 0.480363939847864 2319 6777674
SGTC_103 0844-0104 51.839 µM 0.04838718090792 0.492227614646318 no 1644 0.48070383774615 2326 5375804
SGTC_2805 7950783 58.44 µM 0.0476494073498838 0.492494309512009 no 1645 0.480997827675098 2281 1178958 YDL195W SEC31
SGTC_2483 5729050 27.16 µM 0.0463713751989725 0.492956308205605 no 1646 0.481507125621799 2309 2865180
SGTC_3291 9121177 71.43 µM 0.046057393343677 0.493069811676595 no 1647 0.481632252566127 2278 17015612
SGTC_1583 clindamycin 39.6 µM 0.0458661665343806 0.493138939853083 no 1648 0.481708460488805 2185 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2725 haloperidol 53.21 µM 0.0455618052037606 0.493248966396744 no 1649 0.481829756285336 2321 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_761 k216-0224 480 µM 0.0454710020445665 0.493281791815564 no 1650 0.481865943999476 2340 1340404
SGTC_106 0092-0003 11.579 µM 0.0450239730726638 0.493443393825887 no 1651 0.482044100289259 2326 1072148
SGTC_2379 9035213 200 µM 0.0449491329197403 0.49347044882065 no 1652 0.482073926993757 2345 646551
SGTC_3103 9120822 49.47 µM 0.0443652434012227 0.493681528083649 no 1653 0.482306633052039 2329 17141819
SGTC_3319 9138450 16.7555 µM 0.0432934384230258 0.494068996022521 no 1654 0.482733810849994 2209 2029690
SGTC_2479 5617353 43.85 µM 0.042450812713764 0.494373617370611 no 1655 0.483069661070607 2330 2731746
SGTC_947 3447-0010 211 µM 0.0419242734321582 0.49456397059272 no 1656 0.483279533002929 2329 748350
SGTC_416 estradiol valerate 100 µM 0.0398466951662012 0.495315063381813 no 1657 0.484107674206036 2255 13791 A steroid.
SGTC_1272 0839-0021 27 µM 0.0394821226452784 0.495446866602674 no 1658 0.484253003232565 2282 5027250
SGTC_1078 idebenone 36.1 µM 0.0390334092344671 0.495609089802723 no 1659 0.484431876092362 2286 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1769 st044406 64.4 µM 0.0385604820396568 0.495780067788912 no 1660 0.484620404803772 2298 670903
SGTC_1731 st035964 63 µM 0.0384811982525846 0.495808731436688 no 1661 0.484652011000368 2143 6739575
SGTC_2823 7987624 58.44 µM 0.0380030259301272 0.495981606616982 no 1662 0.484842634714627 2299 2239440
SGTC_3089 9117425 49.47 µM 0.0378536969886233 0.496035594146459 no 1663 0.484902165508295 2203 9401657
SGTC_2851 9015922 71.43 µM 0.0367946089387099 0.496418492794696 no 1664 0.485324386291624 2324 2996893
SGTC_624 k048-0052 28 µM 0.0354375852516779 0.496909110729091 no 1665 0.485865407412788 2282 6835531
SGTC_290 2043-6722 48.1 µM 0.0347452664728034 0.497159413299096 no 1666 0.486141432637499 2318 773758 YLR208W SEC13
SGTC_361 000s-0510 1.45 µM 0.0343497465195851 0.497302411027392 no 1667 0.486299128133299 2301 660
SGTC_269 exalamide 29 µM 0.0336445790590881 0.497557360694226 no 1668 0.486580286712736 2270 3316 A derivative of salicylamide.
SGTC_2842 9000675 19.48 µM 0.0318067020439471 0.498221840098378 no 1669 0.487313100941958 2299 2989072
SGTC_3310 9130229 44.1445 µM 0.0316232528027072 0.498288165970547 no 1670 0.487386249803224 2333 7761258
SGTC_1187 1391-0724 117 µM 0.0313772266521295 0.498377116529675 no 1671 0.487484351353079 2279 6997986
SGTC_3228 9131799 49.47 µM 0.0308028003334559 0.498584800214908 no 1672 0.487713403569002 2287 17015818
SGTC_1487 3970-0795 2.82 µM 0.029956864363923 0.498890648825535 no 1673 0.488050727483894 2291 3765103
SGTC_589 1227-0070 34.1 µM 0.0294677339175706 0.499067494513911 no 1674 0.488245776182111 2329 2841384
SGTC_305 1682-2595 20.8 µM 0.0289081966854767 0.499269796081169 no 1675 0.488468904172765 2312 226033
SGTC_1902 st060212 70.5 µM 0.0284548187907247 0.499433715712987 no 1676 0.488649701402626 2361 688944
SGTC_5 0352-0601 109.883 µM 0.0282650918710789 0.499502311868116 no 1677 0.488725361060329 2296 762456
SGTC_888 0916-0002 6.97 µM 0.027530534822305 0.499767892589172 no 1678 0.489018292903018 2344 2802138 YIL048W NEO1
SGTC_372 0155-0182 15.9 µM 0.0262465856774281 0.499767892589172 no 1679 0.48953032933437 2309 771486
SGTC_1645 Cervolide 78 µM 0.0260558433670621 0.499698929271538 no 1680 0.489606398490757 2326 23173 A fragrance.
SGTC_131 0141-0277 33.849 µM 0.0260026585471091 0.499679700180019 no 1681 0.489627608977608 2348 1547771
SGTC_2383 9036125 200 µM 0.0251614101139738 0.499375545041377 no 1682 0.489963108735742 2306 79580
SGTC_3164 9100705 49.47 µM 0.0247892659417765 0.49924099563928 no 1683 0.490111526483277 2362 17174235
SGTC_1227 3909-8010 46.6 µM 0.0244116129956529 0.499104454618293 no 1684 0.490262142627952 2326 15982272
SGTC_1422 4031-0024 15.5 µM 0.0243051738114774 0.499065971380881 no 1685 0.490304593123318 2364 782427
SGTC_1244 0416-0015 52.5 µM 0.0237213121685229 0.498854875543133 no 1686 0.490537453067916 2345 96201
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.0233145130339202 0.498707797041641 no 1687 0.490699697566933 2357 140250 A respiratory chain inhibitor.
SGTC_1711 st032263 62.8 µM 0.0227885248626283 0.498517625926801 no 1688 0.490909480741122 2306 3958979
SGTC_2187 6125751 200 µM 0.0222719790332304 0.498330869019894 no 1689 0.491115500414253 2320 874498
SGTC_270 tamoxifen 5.46 µM 0.0218118242209957 0.498164500566104 no 1690 0.491299031033593 2367 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_168 3970-0862 530.542 µM 0.0205840809207541 0.497720613000294 no 1691 0.491788719680851 2329 3135186
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.0204419263979962 0.497669217554595 no 1692 0.49184541919992 2368 15053
SGTC_2463 5473429 200 µM 0.0204114677036334 0.497658205330498 no 1693 0.491857567926115 2279 5399405
SGTC_2566 crystal violet carbinol 226 nM 0.0199044257152601 0.497474886513318 no 1694 0.492059807317614 2296 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_950 1165-0508 94.1 µM 0.0192308216320315 0.49723134872919 no 1695 0.492328485019405 2341 6148369
SGTC_613 3914-0030 117 µM 0.0191429711616857 0.497199586957715 no 1696 0.492363525835863 2358 1145395
SGTC_309 k408-0051 1.48 µM 0.0179314945175395 0.496761587281157 no 1697 0.492846752028986 2355 3640463
SGTC_3340 9146634 11.102 µM 0.0175477526241728 0.496622849262465 no 1698 0.492999818807561 2350 4907387
SGTC_2689 tacrolimus 100 µM 0.0175414608170943 0.496620574526308 no 1699 0.493002328489138 2357 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1135 dihydrocapsaicin 536.708 nM 0.0173300833843596 0.496544153320407 no 1700 0.493086643066973 2374 107982 A Capsaicinoid.
SGTC_2218 6965428 192.983 µM 0.0160529433235658 0.49608242005581 no 1701 0.493596077229793 2373 675684
SGTC_335 4077-0256 27.6 µM 0.0140450756914156 0.49535651265658 no 1702 0.494397009687383 2376 3121989
SGTC_2798 7813637 45.45 µM 0.01387418977271 0.495294732689971 no 1703 0.494465176663178 2372 956368
SGTC_3317 9138495 8.753 µM 0.0138619453268517 0.495290305989839 no 1704 0.494470061020621 2380 17020139
SGTC_2996 9066192 71.4286 µM 0.0129014792312255 0.494943073229744 no 1705 0.494853197234653 2375 6472854
SGTC_292 k038-0015 474 µM 0.0127012920712081 0.494870700987352 no 1706 0.494933053813109 2366 46368540
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.0124099579715638 0.494765377341395 no 1707 0.49504927014202 2376 1377
SGTC_1268 0828-0275 2.46 µM 0.0118077716977725 0.494547675003747 no 1708 0.49528949009196 2372 745337
SGTC_3180 9109287 49.47 µM 0.0117493885300791 0.494526568410544 no 1709 0.495312779990396 2372 18891271
SGTC_245 methotrexate 289.6 µM 0.0110605714752285 0.49427754949865 no 1710 0.495587560360193 2315 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2857 9024691 58.44 µM 0.00912669222278812 0.493578431962434 no 1711 0.496359027138912 2381 16478292
SGTC_1292 0kpi-0043 232 µM 0.00847993803745596 0.493344627868224 no 1712 0.496617034726195 2382 3333905
SGTC_1064 honokiol 6.76 µM 0.00841696592626565 0.493321863331727 no 1713 0.49664215606728 2368 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_622 1348-1566 26.3 µM 0.00796204619337222 0.493157409644297 no 1714 0.496823636695481 2378 7340407
SGTC_2297 7971671 152.32 µM 0.00359771014316122 0.491579763370143 no 1715 0.498564724407517 2396 909016
SGTC_750 4073-0104 132 µM 0.00343577991211234 0.491521230244351 no 1716 0.498629324823613 2396 22330957
SGTC_378 3970-0959 8.33 µM 0.000850168553742921 0.490586631614541 no 1717 0.499660831859302 2403 6615653
SGTC_3242 9133940 49.47 µM 0.000503854193917806 0.490461456162814 no 1718 0.499798991267394 2404 17248444
SGTC_788 1182-0090 188 µM 0.000333998017689602 0.490400061928545 no 1719 0.499866754071651 2403 5715185
SGTC_1034 k072-0165 12.7 µM -0.00122692900587686 0.489835878269436 no 1720 0.49951052626731 2407 5835461
SGTC_799 1310-0557 151 µM -0.00188390052054145 0.489598427576644 no 1721 0.499248432874848 2414 5354492
SGTC_792 4534-1957 155 µM -0.00189881241787346 0.489593037978508 no 1722 0.499242483899162 2416 1717904
SGTC_1204 4049-0315 18.3 µM -0.00243046652521752 0.489400883801439 no 1723 0.499030385096603 2413 588402
SGTC_2936 9038235 15.59 µM -0.00243857374382876 0.489397953652241 no 1724 0.499027150793908 2410 4749415
SGTC_421 streptovitacin 30 mM -0.002652706463321 0.489320561002165 no 1725 0.498941724475442 2434 91467 include heat shock
SGTC_1744 st037937 38.9 µM -0.00273515270864062 0.489290763078217 no 1726 0.498908833301683 2415 1016152
SGTC_2522 biochanin a 4.94 µM -0.00312209948529178 0.489150912627657 no 1727 0.498754464535175 2411 5280373 A possible chelator.
SGTC_3049 9092223 49.47 µM -0.00319687947734539 0.489123885767873 no 1728 0.498724631783525 2418 8623917
SGTC_2705 st078069 42.8 µM -0.00495169002720173 0.488489679674055 no 1729 0.498024569561384 2420 1530061
SGTC_1856 st057054 55.7 µM -0.00504098376674928 0.488457408787581 no 1730 0.497988946957948 2419 1266018
SGTC_2283 7944793 200 µM -0.00550123563147905 0.488291074301983 no 1731 0.497805335581896 2419 2970533
SGTC_789 1309-1135 70.6 µM -0.0055175737508074 0.488285169762027 no 1732 0.497798817714235 2416 3092424
SGTC_2441 5730946 39.09 µM -0.00739166569774579 0.48760789676309 no 1733 0.497051178882921 2420 1774275
SGTC_2259 7964009 200 µM -0.00860120401434087 0.487170803848183 no 1734 0.496568658365222 2457 313134
SGTC_2555 cholic acid 100 µM -0.00869357329975073 0.487137424829419 no 1735 0.496531809729621 2480 6708657 Influences liver metabolism.
SGTC_3052 9092717 49.47 µM -0.00870454869591867 0.487133458712324 no 1736 0.496527431345713 2440 25237534
SGTC_637 1181-0519 7.26 µM -0.00927942709312173 0.486925719932296 no 1737 0.496298097321823 2425 6252091 YGR060W ERG25
SGTC_1357 1503-1303 39.5 µM -0.0096769171052248 0.486782084513124 no 1738 0.496139528873719 2428 292895
SGTC_2893 9048488 25.97 µM -0.0113857065782005 0.486164622868533 no 1739 0.495457858390159 2424 6467338
SGTC_218 alverine citrate 93.75 µM -0.0114008016617133 0.486159168489037 no 1740 0.495451836713957 2415 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2048 5246248 200 µM -0.0128778776989292 0.48562546214619 no 1741 0.494862612101625 2433 677046
SGTC_1749 st037932 54.2 µM -0.0130384022451173 0.485567461948202 no 1742 0.49479857744954 2462 594497
SGTC_2370 9071495 200 µM -0.0135730669617137 0.48537428087049 no 1743 0.494585295971578 2455 21791103
SGTC_823 0417-1665 178 µM -0.0142706176013835 0.485122252230101 no 1744 0.494307040501057 2447 3429856
SGTC_2664 lyso-paf C-16 73.48 µM -0.0145180341169792 0.485032860790772 no 1745 0.494208345817499 2436 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2012 4023501 200 µM -0.014720524511343 0.484959701691712 no 1746 0.494127572469986 2427 3477460
SGTC_3056 9094900 49.47 µM -0.014950214112769 0.484876716223512 no 1747 0.494035949659914 2441 25236784
SGTC_3334 9142812 21.919 µM -0.0178060682291936 0.483844969193275 no 1748 0.49289678189071 2492 45283678
SGTC_2811 7967822 32.47 µM -0.0180938312616538 0.483741013655142 no 1749 0.492781999543687 2461 2232244
SGTC_257 daunorubicin 18.5 µM -0.0189754829945566 0.483422520376328 no 1750 0.492430331812244 2506 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1669 st015249 58.4 µM -0.019176566747962 0.483349881122124 no 1751 0.492350125595881 2442 722793
SGTC_2434 5670830 169.91 µM -0.019712111868828 0.48315642414659 no 1752 0.492136514391786 2467 1549830
SGTC_1609 st001574 46.4 µM -0.0198071896155136 0.483122079268229 no 1753 0.49209859126287 2439 3960012
SGTC_2235 salicylic acid 500 µM -0.0206883561546081 0.482803781991308 no 1754 0.491747128738054 2437 338 A COX inhibitor and kinase inhibitor.
SGTC_3151 9099821 49.47 µM -0.0208584079136675 0.48274235670645 no 1755 0.491679302537804 2468 17174189
SGTC_2998 9066762 71.4286 µM -0.0223847949866665 0.482191020966012 no 1756 0.491070504578436 2467 4945196
SGTC_1565 sinapyl alcohol 95.1 µM -0.0239278272440227 0.481633707553038 no 1757 0.490455088851604 2462 5280507 A phenol propionate derived from cinnamic acid.
SGTC_668 1682-0499 62.6 µM -0.0248734466774155 0.481292185767532 no 1758 0.490077953580704 2475 682214
SGTC_1992 st073643 23.3 µM -0.0263800758963439 0.480748077044148 no 1759 0.489477092875487 2440 3161292
SGTC_349 k015-0014 24 µM -0.0276016866021124 0.480306927068506 no 1760 0.488989918232602 2460 2196908
SGTC_403 arphamenine a 50 µM -0.0277178411810373 0.480264982391815 no 1761 0.488943596982749 2473 5487158 An arginine aminopeptidase inhibitor.
SGTC_1955 wogonin 32.4 µM -0.0280295353535549 0.480152427330915 no 1762 0.488819297295515 2564 5281703 A flavanone.
SGTC_3272 9137413 49.47 µM -0.0286095207268819 0.479942994560435 no 1763 0.488588009375874 2455 17614870
SGTC_706 4262-0057 46.9 µM -0.0296619206377893 0.4795629870362 no 1764 0.488168340738989 2459 883298
SGTC_2816 7982706 58.44 µM -0.0322849543367176 0.478615926259188 no 1765 0.487122403825414 2504 2981853
SGTC_2625 euphol 100 µM -0.0346245621587697 0.477771299659543 no 1766 0.486189557734769 2482 6708538 A triterpene alcohol.
SGTC_1872 amphotericin b 148 nM -0.0348290751485537 0.47769747269732 no 1767 0.486108018037699 2471 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_918 glabranin 770.725 nM -0.0352528385375453 0.477544501167379 no 1768 0.48593906466433 2486 124049 Also referred to as licorice root.
SGTC_23 0213-0011 39.996 µM -0.0356645174489067 0.477395895100847 no 1769 0.485774931757853 2483 627608
SGTC_1600 coumarin 106 71.1 µM -0.0366454391600363 0.477041818944593 no 1770 0.485383856316215 2605 100336 A hepatotoxic, DNA x-linker.
SGTC_3206 9114350 49.47 µM -0.0374797934021271 0.476740662431846 no 1771 0.485051225677291 2459 17087243
SGTC_2357 9067248 200 µM -0.0376123966379984 0.476692801093039 no 1772 0.484998361914425 2496 9150235
SGTC_2900 5328528 85.29 µM -0.0377491580404017 0.476643439272651 no 1773 0.484943840728171 2461 795359
SGTC_1726 st035556 14.5795 µM -0.0384770265311099 0.476380732939185 no 1774 0.484653674044803 2677 5919439
SGTC_1771 st048882 4.1505 µM -0.0386752232605455 0.476309200449561 no 1775 0.48457466379986 2471 4580403
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.040113101890686 0.475790269187948 no 1776 0.484001478205527 2472 2724 A muscle relaxant with antifungal properties.
SGTC_2627 acetyl isogambogic acid 100 µM -0.0403027694829391 0.475721821086283 no 1777 0.483925872923278 2532 6857789 A caspase activator and apoptosis inducer.
SGTC_3029 9088683 49.47 µM -0.0410541368365293 0.47545067128545 no 1778 0.483626368627749 2547 25236615
SGTC_208 k072-0098 12.366 µM -0.0411028354868111 0.475433097544047 no 1779 0.483606957062012 2497 5948901
SGTC_1048 3161-0300 24.5 µM -0.0421730820393184 0.475046892885753 no 1780 0.483180360441896 2489 2165101
SGTC_1101 ebselen 5.29 µM -0.0423875714173131 0.474969495961723 no 1781 0.483094868008891 2474 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2795 7780010 54.55 µM -0.0441341690819639 0.474339284383662 no 1782 0.48239872816076 2540 953673
SGTC_1880 MG-132 525 µM -0.0455973619005899 0.473811380983735 no 1783 0.4818155859427 2520 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2720 fluspirilene 36.88 µM -0.046154791025356 0.473610278913977 no 1784 0.481593437790516 2534 3396 An atypical antipsychotic.
SGTC_1067 clotrimazole 1.36 µM -0.0461882497840413 0.473598208309217 no 1785 0.481580103897264 2504 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_976 1348-1067 47.6 µM -0.0461922234773575 0.473596774758498 no 1786 0.481578520313211 2495 5310671 YGL099W LSG1
SGTC_1077 5-fluorocytosine 377 nM -0.0499647584244683 0.47223595088297 no 1787 0.48007523596529 2548 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2712 st079126 47.7 µM -0.050418717078998 0.472072221038354 no 1788 0.479894360641055 2481 3152970
SGTC_2799 7812892 81.82 µM -0.0508311231199825 0.471923482118056 no 1789 0.47973004513142 2532 20205235
SGTC_2070 5230947 200 µM -0.0508362988816155 0.471921615445704 no 1790 0.479727982967377 2489 2835538
SGTC_995 3931-2021 34.6 µM -0.0509142085334192 0.471893516893742 no 1791 0.479696941711144 2542 730143
SGTC_1306 1185-0270 9.02 µM -0.0518297703335754 0.471563324925267 no 1792 0.479332167064149 2514 1548076
SGTC_796 1234-0020 70.7 µM -0.0523861243863109 0.471362688646929 no 1793 0.479110515035879 2489 46495034
SGTC_2968 9090663 33.37 µM -0.0531226244502391 0.471097098045085 no 1794 0.478817102598612 2604 25236811
SGTC_444 curcumin 90.4 µM -0.0536330749163096 0.470913031126697 no 1795 0.478613752226711 2547 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2858 9025781 8.96 µM -0.0558522104574841 0.470112890192435 no 1796 0.477729770945847 2539 4894980 YPL153C RAD53
SGTC_857 0438-0306 1.35 µM -0.0559018944847198 0.470094977277541 no 1797 0.477709980805685 2570 4686136
SGTC_633 0437-0093 97.7 µM -0.0559259771503005 0.470086294614699 no 1798 0.477700388218865 2493 2831118
SGTC_875 0709-0210 25.7 µM -0.0564829836596138 0.469885477810437 no 1799 0.47747852547754 2501 6251364
SGTC_579 4491-1009 110 µM -0.0566803244638042 0.469814332631802 no 1800 0.47739992380896 2495 1271041
SGTC_2963 9082507 9 µM -0.0568899566613484 0.469738757223632 no 1801 0.477316427390039 2581 16459611
SGTC_1361 1608-0041 5.61 µM -0.0586193794725261 0.469115317387455 no 1802 0.476627637318813 2516 X1361
SGTC_1694 st024011 44.9 µM -0.0588323377643975 0.469038553232504 no 1803 0.476542825624714 2515 2787533
SGTC_536 3852-0578 10.6 µM -0.058976505715132 0.468986586287627 no 1804 0.476485410627484 2520 2869208
SGTC_570 0987-0065 62.6 µM -0.0597177715093055 0.468719397130953 no 1805 0.476190208688783 2516 3104428
SGTC_1941 st076221 61.8 µM -0.0614537136616778 0.468093732351421 no 1806 0.475498937919827 2558 2828568
SGTC_3166 9102297 49.47 µM -0.0614817971987658 0.468083611183047 no 1807 0.475487755354925 2545 25237072
SGTC_521 r062-0005 13.8 µM -0.0640112646653287 0.467172088977885 no 1808 0.474480628649232 2497 2832033
SGTC_495 decylubiquinone 155 µM -0.0672686872055394 0.465998494156914 no 1809 0.473183902198074 2582 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2697 mebhydrolin 72.4 µM -0.0674877936578425 0.465919564266597 no 1810 0.473096689560524 2551 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2980 9014342 25.29 µM -0.0688541089121476 0.465427399573126 no 1811 0.472552873780394 2671 2996599
SGTC_1037 k284-1091 78.7 µM -0.0697414986289933 0.465107778422776 no 1812 0.472199705523337 2510 3334711
SGTC_1892 st058411 7.36 µM -0.070786108464296 0.464731558391934 no 1813 0.471783993964395 2529 3934738
SGTC_1616 st002734 56.1 µM -0.0716933706377266 0.464404830190689 no 1814 0.471422966026231 2563 4026101
SGTC_733 4069-0007 56.1 µM -0.0723860494452598 0.464155395066773 no 1815 0.471147343299756 2534 5717425 YNL287W SEC21
SGTC_1211 1056-0033 32.3 µM -0.0727046883268978 0.464040657247092 no 1816 0.471020558840124 2558 6741922
SGTC_2493 resveratrol 26.09 µM -0.0731704755065944 0.46387293857534 no 1817 0.470835230262258 2511 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1181 1222-0449 220 µM -0.0738093946294553 0.463642889736947 no 1818 0.470581025792387 2612 658318
SGTC_822 1487-0950 154 µM -0.0752442420523662 0.463126303849013 no 1819 0.470010192017378 2540 1958375
SGTC_720 r052-1644 49.9 µM -0.0765373907420551 0.462660786778642 no 1820 0.469495783846253 2608 1422863 YOR257W CDC31
SGTC_459 nigericin 15.3 µM -0.0774137107478129 0.462345351757863 no 1821 0.469147216957566 2622 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1874 staurosporine 7.6 µM -0.0774334676778008 0.462338240441177 no 1822 0.469139358671099 2615 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2054 5233173 129 µM -0.0833893000457921 0.460195055057987 no 1823 0.466770998102942 2633 6889
SGTC_1003 4049-0218 100 µM -0.085793594684821 0.459330202063722 no 1824 0.465815249203262 2643 295161
SGTC_3266 9136860 49.47 µM -0.0872700040388786 0.458799215396519 no 1825 0.465228448169854 2565 4871271 YPR165W RHO1
SGTC_539 4859-0462 2.54 µM -0.0879963651586364 0.458538008483594 no 1826 0.464939782560036 2659 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1647 st011722 22.4 µM -0.0886747476683601 0.45829407133654 no 1827 0.464670200949915 2636 2854783
SGTC_2988 9073640 71.4286 µM -0.0887140123806849 0.458279952758661 no 1828 0.464654598088359 2659 9102229
SGTC_1396 3511-0007 98.6 µM -0.0894299653265874 0.458022523792272 no 1829 0.464370104993309 2643 X1396
SGTC_2002 4023503 131 µM -0.0898359180142996 0.457876566734668 no 1830 0.464208802563658 2557 4736863 YCR052W RSC6
SGTC_3043 9092303 49.47 µM -0.0905165423844262 0.457631866415535 no 1831 0.463938374495902 2592 25236084
SGTC_975 1335-0046 28.5 µM -0.0910274880267175 0.457448180100681 no 1832 0.463735374717786 2599 16486740
SGTC_3247 9135149 49.47 µM -0.0910469526309862 0.457441182703253 no 1833 0.463727641575931 2545 8934436 YOR116C RPO31
SGTC_2676 harmalol 100 µM -0.0917999295403705 0.457170502596045 no 1834 0.463428500022838 2570 5459187 A monoamine oxidase inhibitor
SGTC_2453 5731132 22.18 µM -0.0922902082609852 0.456994267894522 no 1835 0.463233733921853 2641 1362040
SGTC_543 3844-1095 191 µM -0.0927116517811135 0.456842783328047 no 1836 0.46306632005026 2669 4230703
SGTC_2806 7952793 58.44 µM -0.0930611770611445 0.456717153965019 no 1837 0.46292747988104 2676 2972490
SGTC_1377 2944-0135 198 µM -0.0937917885813185 0.456454565315705 no 1838 0.462637277346774 2636 1894137
SGTC_1094 duloxetine 25.4 µM -0.0952964406571459 0.455913839245545 no 1839 0.462039684866753 2555 60834 A selective serotonin reuptake inhibitor.
SGTC_1683 st010134 710 nM -0.0961798073478553 0.455596422168608 no 1840 0.46168888392922 2569 3818134
SGTC_232 clozapine 119 µM -0.0964699419255285 0.455492175294193 no 1841 0.461573672713885 2579 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1534 6-azauridine 81.6 µM -0.096730010838741 0.455398733774926 no 1842 0.461470403187344 2551 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1737 st035557 69.7 µM -0.0968158134486293 0.455367905847757 no 1843 0.461436332807091 2552 5716916
SGTC_2308 7584454 197.62 µM -0.0977861110949477 0.455019307400669 no 1844 0.461051068132095 2624 893577
SGTC_1365 1672-3266 55.4 µM -0.0980242111998292 0.454933770553278 no 1845 0.460956534095227 2588 6415873
SGTC_2864 9034755 47.6 µM -0.100734636588236 0.453960205470912 no 1846 0.459880557595352 2574 4930451
SGTC_590 k048-0076 22.4 µM -0.103417504615722 0.45299681113125 no 1847 0.458815809980478 2661 6832814
SGTC_2330 7979373 200 µM -0.103643630484672 0.452915623878312 no 1848 0.458726080985389 2621 1863007
SGTC_1571 st070080 73.4 µM -0.104329123310569 0.452669519542998 no 1849 0.458454083479268 2696 4315245
SGTC_1846 st056244 14.8 µM -0.104619240086992 0.452565367837916 no 1850 0.45833897355267 2663 5393182
SGTC_990 3985-0011 41.3 µM -0.104836456334169 0.452487389504317 no 1851 0.458252790729395 2669 5399565 YGL099W LSG1
SGTC_3259 9138485 49.47 µM -0.107014266551915 0.451705680472779 no 1852 0.457388830839521 2627 17646153
SGTC_928 2764-0428 58.7 µM -0.107023127341584 0.451702500337567 no 1853 0.457385316080891 2716 662578
SGTC_1841 st054148 70 µM -0.108388447771098 0.451212524328247 no 1854 0.456843782245715 2654 675442
SGTC_2303 7774051 200 µM -0.108404847695874 0.451206639295859 no 1855 0.456837277947006 2692 2953184
SGTC_1650 st011916 45.8 µM -0.108485127414277 0.451177831468311 no 1856 0.456805438744138 2619 242528
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.109533413305934 0.450801684906813 no 1857 0.456389710604518 2598 17037758
SGTC_2617 dihydrotanshinone i 20.83 µM -0.109958018878884 0.450649340237439 no 1858 0.456221334520533 2620 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_897 1000-0139 31.4 µM -0.109966141258124 0.450646426071452 no 1859 0.456218113691602 2602 6151020
SGTC_248 streptozotocin 5.23457 mM -0.111792044405425 0.44999139214183 no 1860 0.455494147813331 2695 5300 DNA alkylating agent.
SGTC_2164 5685496 200 µM -0.111794089274908 0.449990658630818 no 1861 0.455493337110255 2604 759046
SGTC_2646 retinol 96.75 µM -0.113157883183123 0.449501493043058 no 1862 0.454952692743555 2680 445354 A vitamin A analog and teratogen.
SGTC_2781 5567276 71.43 µM -0.11327515209984 0.449459434601081 no 1863 0.454906208090922 2762 2853274
SGTC_1862 st057513 3.81 µM -0.114977809360431 0.448848841580422 no 1864 0.454231355471846 2631 5393163
SGTC_2743 auranofin 4.32 µM -0.115131984246993 0.448793558602736 no 1865 0.454170254349422 2653 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1613 st002381 52.1 µM -0.11617684742785 0.448418924954964 no 1866 0.453756192781159 2623 551167
SGTC_2360 9040895 200 µM -0.117431709903234 0.447969057288799 no 1867 0.453258978517838 2653 4914414
SGTC_169 k015-0017 16.025 µM -0.117432414161883 0.447968804831105 no 1868 0.453258699489873 2672 1840002
SGTC_3067 9117431 49.47 µM -0.117485967558829 0.44794960744722 no 1869 0.453237481649266 2667 17150885
SGTC_1525 8-methoxypsoralen 92.5 µM -0.117704688045006 0.447871203581773 no 1870 0.453150826041624 2659 4114 Related to psoralen; DNA damaging agent.
SGTC_2426 5582046 32.21 µM -0.118090822342071 0.447732792524547 no 1871 0.452997847639454 2733 2251934
SGTC_3314 9135860 59.4275 µM -0.119167153519898 0.447347011863174 no 1872 0.452571464436122 2632 25252478
SGTC_810 3825-7150 143 µM -0.12005881095004 0.447027460023227 no 1873 0.452218280208078 2632 22330411 YGL099W LSG1
SGTC_1478 0453-0656 35.7 µM -0.120965805622552 0.446702446909366 no 1874 0.451859059709847 2628 5258496
SGTC_1920 st075728 45.7 µM -0.122022137390406 0.44632396537215 no 1875 0.451440743086688 2647 3400306
SGTC_126 0417-1624 672.48 µM -0.123066837138147 0.445949699653413 no 1876 0.451027085872128 2612 41912 YDL195W SEC31
SGTC_2353 9059630 146.67 µM -0.12365555743741 0.44573881065278 no 1877 0.450794000764183 2717 4779114
SGTC_3332 9141069 11.198 µM -0.12516976337571 0.445196468594622 no 1878 0.450194577141229 2629 17332883
SGTC_1655 st012546 55.1 µM -0.126650384354037 0.444666254796976 no 1879 0.449608558522141 2718 720985 YLR208W SEC13
SGTC_407 eburnamonine 100 µM -0.128166117242876 0.444123569890566 no 1880 0.449008756704083 2625 3195
SGTC_3292 9120825 59.784 µM -0.129354351485932 0.443698214041831 no 1881 0.448538633185938 2646 24824900
SGTC_3328 9140624 29.0385 µM -0.130057692188163 0.443446467543195 no 1882 0.448260391242501 2776 4904392
SGTC_2086 5274770 176.623 µM -0.1308317844216 0.443169423359762 no 1883 0.447954189382241 2692 689278
SGTC_1230 0170-0365 3.77 µM -0.131595580717083 0.442896091274436 no 1884 0.447652090601534 2727 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2495 cafestol 54.53 µM -0.133126935038066 0.442348162917879 no 1885 0.447046496828681 2841 16667697 An anti-infammatory.
SGTC_2296 7971656 126.45 µM -0.133456623289959 0.442230212745425 no 1886 0.44691613346849 2689 666570
SGTC_2693 st077581 40.7 µM -0.134061568862532 0.442013799086701 no 1887 0.446676944430022 2650 25238761
SGTC_53 0973-0023 39.979 µM -0.135927721136363 0.441346309762165 no 1888 0.445939210279739 2634 674768
SGTC_1269 0831-0796 3.05 µM -0.136087390672964 0.441289206530342 no 1889 0.445876097787751 2739 927758
SGTC_1794 st048918 76.9 µM -0.136920103800595 0.44099141993135 no 1890 0.445546973978399 2608 672303
SGTC_2970 9090938 41.86 µM -0.137532564085385 0.440772419249145 no 1891 0.445304927439479 2728 17217104
SGTC_527 4476-4215 268 µM -0.139102323599236 0.440211194850742 no 1892 0.444684646056145 2672 4418754
SGTC_1967 st070177 51.4 µM -0.139276247061346 0.440149020663934 no 1893 0.444615929513442 2787 5729214
SGTC_988 1497-1057 103 µM -0.140134893204364 0.439842093361401 no 1894 0.444276705902231 2652 3533044
SGTC_1511 0906-3109 28.5 µM -0.140199622739989 0.439818956932452 no 1895 0.44425113498564 2640 2882180
SGTC_1320 1313-0481 95.3 µM -0.140541380886288 0.439696804929842 no 1896 0.444116129847843 2667 6813365 YLR208W SEC13
SGTC_2189 6047310 154.431 µM -0.142792946731408 0.438892188984097 no 1897 0.443226853845225 2637 711535
SGTC_467 ro 31-8220 72.8 µM -0.142794087011564 0.438891781559096 no 1898 0.443226403553462 2754 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2445 5742597 35.57 µM -0.143403681434193 0.438673981201081 no 1899 0.442985687831241 2674 1774255
SGTC_828 2074-0507 139 µM -0.143474204565608 0.438648785377572 no 1900 0.442957841120237 2782 X828
SGTC_2941 9056145 11.23 µM -0.144736831476701 0.438197728395093 no 1901 0.442459329010568 2628 2119517
SGTC_2115 tiliquinol 12.7705 µM -0.145172379944791 0.438042152982369 no 1902 0.44228738625185 2776 71208 A bioactive hydroxyquinoline.
SGTC_717 1532-0246 73.2 µM -0.145280522823068 0.438003526450016 no 1903 0.442244696051025 2740 9561992
SGTC_2415 st077333 57.7 µM -0.145320219855809 0.437989347590363 no 1904 0.442229025522086 2701 2766255
SGTC_1915 st067105 30.6 µM -0.146446348934694 0.437587153625439 no 1905 0.441784520263259 2633 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_3106 9121286 49.47 µM -0.146455899647934 0.437583742889102 no 1906 0.441780750721905 2872 15943471
SGTC_1253 0550-0034 176 µM -0.146852458048986 0.437442128646921 no 1907 0.441624238976456 2763 5969915
SGTC_293 4049-0273 38.5 µM -0.147495502271644 0.437212509346566 no 1908 0.441370464786139 2687 1380311
SGTC_362 0310-0100 9.03 µM -0.14861085909132 0.436814286073651 no 1909 0.440930351926022 2777 790235
SGTC_2610 ononetin 44.17 µM -0.149631300275639 0.436450007230444 no 1910 0.440527756069007 2749 259632
SGTC_1922 5578187 25 µM -0.150415621258885 0.436170055593481 no 1911 0.440218358748963 2911 1350412
SGTC_1828 st055811 49 µM -0.151949276474076 0.435622732830907 no 1912 0.439613471243512 2791 5877589
SGTC_972 1319-0219 195 µM -0.152193851396481 0.435535461597081 no 1913 0.43951702167389 2736 23903702
SGTC_1305 1181-0477 144 µM -0.152450159444953 0.43544400702181 no 1914 0.439415948929116 2800 6252086
SGTC_2898 9056270 58.44 µM -0.153047580358585 0.435230851645594 no 1915 0.439180376774262 2658 19154699
SGTC_1470 k295-0292 231 µM -0.157682337014342 0.433577848620276 no 1916 0.437353559689908 2787 5045612
SGTC_2950 9072895 21.46 µM -0.160120439647514 0.432708754554003 no 1917 0.436393100199112 2781 17332245
SGTC_2486 5283202 22.39 µM -0.16078844908609 0.432470690335238 no 1918 0.43613001157812 2762 1377751
SGTC_2339 9000433 200 µM -0.160884646057618 0.432436409817504 no 1919 0.436092127718832 2749 2988954
SGTC_2065 5221596 34.26 µM -0.161469417558034 0.432228033026246 no 1920 0.435861848260296 2815 788581
SGTC_423 5-fluorouracil 457 µM -0.162143218236243 0.431987955059469 no 1921 0.435596536618016 2668 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2057 5236571 38.335 µM -0.162556526745123 0.431840703951003 no 1922 0.435433809117105 2795 54684039 YBR257W POP4
SGTC_71 0417-1750 47.813 µM -0.162566009520232 0.431837325595079 no 1923 0.435430075694541 2870 6811472
SGTC_1561 5-methoxyflavone 52.9 µM -0.163988879552159 0.431330467174601 no 1924 0.434869949064744 2677 94525
SGTC_392 N-ethylmaleimide 8.33 µM -0.164620047255428 0.431105667141321 no 1925 0.434621525534369 2743 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1212 0520-0165 585 µM -0.168212033111349 0.429826753445932 no 1926 0.433208237388727 3110 5403258
SGTC_1314 1222-0010 41.1 µM -0.168515302525879 0.429718808963669 no 1927 0.433088953070999 2754 3526027
SGTC_456 gingerol 170 µM -0.169215801321862 0.429469496366706 no 1928 0.432813450680198 2867 442793 A herb.
SGTC_2934 9036370 36.88 µM -0.169365262013857 0.429416305861172 no 1929 0.432754672820263 2813 6462800
SGTC_2198 6589944 200 µM -0.169995336041962 0.429192087383304 no 1930 0.432506902282672 2738 5290268
SGTC_2029 5175081 200 µM -0.171008292814637 0.428831663963601 no 1931 0.432108622463428 2702 1380876
SGTC_676 falcarinol 140 µM -0.171026765938564 0.428825091531773 no 1932 0.432101359740015 2812 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_457 grayanotoxin iii 135 µM -0.172124486741199 0.428434576127322 no 1933 0.431669831207692 2754 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_3293 9120939 62.045 µM -0.172497593263028 0.428301858999974 no 1934 0.431523176649934 2854 934087
SGTC_2825 7998094 58.44 µM -0.172836996630039 0.428181137411111 no 1935 0.431389777769887 2800 2987815
SGTC_753 1322-0200 289 µM -0.174178845724847 0.42770392416929 no 1936 0.430862455036774 2856 5403907
SGTC_649 1123-0311 367 µM -0.174706354285374 0.427516350716112 no 1937 0.430655187286109 2803 693629 YIL048W NEO1
SGTC_2428 5615643 7.78 µM -0.175031654797897 0.42740068731544 no 1938 0.430527380289478 2833 2253075
SGTC_1579 chlormadinone acetate 49.4 µM -0.175494477537748 0.42723613745829 no 1939 0.430345554865751 2882 45114258 A steroidal progestin.
SGTC_192 3455-0609 60.9 µM -0.175562443163599 0.427211974339197 no 1940 0.430318855003091 2837 3769639
SGTC_2726 cimetidine 79.27 µM -0.17594590148453 0.427075652470069 no 1941 0.430168221819982 2707 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_665 3914-0008 307 µM -0.177422630736028 0.426550747324891 no 1942 0.429588216271525 2719 1069549
SGTC_3042 9091578 49.47 µM -0.17834017127205 0.426224671917239 no 1943 0.429227916171158 2698 25236497
SGTC_2405 ticlatone 3.52 µM -0.180080162104199 0.425606452923506 no 1944 0.428544818176496 2638 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.180385612285486 0.425497945252909 no 1945 0.428424924393534 2851 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3138 9097216 49.47 µM -0.181015183522301 0.425274315106617 no 1946 0.428177829080451 2665 25237486
SGTC_2354 9060492 162 µM -0.182080021273137 0.424896128593399 no 1947 0.427759963678803 2866 6471895
SGTC_1939 st074455 53.6 µM -0.185162035868393 0.423801914653089 no 1948 0.426550972571947 2973 1644229
SGTC_88 0180-0332 8.668 µM -0.187852533747206 0.42284718145119 no 1949 0.425496126393819 2710 3101745
SGTC_2148 5546263 113.568 µM -0.189056385649905 0.422420136467059 no 1950 0.425024312091555 2733 792097
SGTC_1674 st016616 23.6 µM -0.189744103214835 0.422176221818072 no 1951 0.42475482958997 2690 625830
SGTC_1433 4060-0023 7.6 µM -0.190988493071203 0.421734946622833 no 1952 0.424267304208106 2859 3840627
SGTC_2489 cantharidin 73.42 µM -0.19103144379331 0.421719717545572 no 1953 0.42425047909625 2725 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_801 0866-0028 10.1 µM -0.191653685846644 0.421499101750448 no 1954 0.42400674334957 2733 6849771
SGTC_1434 4073-0095 163 µM -0.191800648258016 0.42144699985139 no 1955 0.423949181577861 2765 24133745
SGTC_564 3555-0129 330 µM -0.193824272430236 0.420729714037005 no 1956 0.423156740377728 2741 563260
SGTC_2450 5739737 12.93 µM -0.194118913920964 0.420625298466583 no 1957 0.42304138607269 2827 2262825
SGTC_2709 st078560 56 µM -0.196906620714984 0.419637663388189 no 1958 0.421950306265679 2876 17250903
SGTC_1553 gossypol 38.6 µM -0.199583908967275 0.418689623849654 no 1959 0.420903006684956 2715 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1523 st012844 44.7 µM -0.199768998490216 0.418624100218439 no 1960 0.420830624099494 2886 4274103
SGTC_233 rapamycin 362 pM -0.200252904857581 0.418452802963946 no 1961 0.420641396466224 2799 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_870 0573-2213 57.6 µM -0.201500122299994 0.418011373788024 no 1962 0.420153766905535 2734 3916321
SGTC_1341 1486-1360 280 µM -0.202155738250566 0.417779372216578 no 1963 0.419897487220136 2750 3976547
SGTC_1763 st044482 94.5 µM -0.202402270336252 0.417692139773839 no 1964 0.419801126830947 2902 88505
SGTC_2288 7946289 167.31 µM -0.203389824135173 0.417342746269046 no 1965 0.41941517637836 2947 1246052
SGTC_1440 4100-1550 40 µM -0.203466981489797 0.417315450978517 no 1966 0.419385025416891 2773 742806
SGTC_109 0132-0036 33.701 µM -0.205590307241687 0.4165644571829 no 1967 0.418555474746715 2731 67274 A color developer.
SGTC_2007 4011539 71.82 µM -0.206222206909442 0.416341020821179 no 1968 0.418308671021617 2758 45595301
SGTC_367 0335-0881 7.1 µM -0.206941452434979 0.416086732326365 no 1969 0.418027791395321 2921 23828853
SGTC_3321 9137793 26.8275 µM -0.20750719829735 0.415886738149298 no 1970 0.41780688579454 2770 4904192
SGTC_2724 maprotiline 69.64 µM -0.20790673464216 0.415745513042169 no 1971 0.417650895294957 2809 4011 A tricyclic antidepressant.
SGTC_880 0833-0487 87.2 µM -0.208793683696933 0.415432039864648 no 1972 0.417304651174808 2782 76075
SGTC_1090 efavirenz 20.7 µM -0.209042049374686 0.415344269963168 no 1973 0.417207706515405 2822 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1808 st050063 61.5 µM -0.210006461035772 0.415003496787547 no 1974 0.416831315152537 2902 4011993
SGTC_1891 st059073 26.2 µM -0.210893728405191 0.414690038878436 no 1975 0.416485099040172 2972 688754
SGTC_157 1348-1695 65.819 µM -0.211694436966905 0.414407207481733 no 1976 0.416172714201692 2778 5380510
SGTC_1727 st034309 9.9045 µM -0.211750885275747 0.414387270121989 no 1977 0.416150693707901 3075 870305
SGTC_1157 4092-0394 27.6 µM -0.212809750903139 0.414013323146274 no 1978 0.415737678916564 2966 3659885
SGTC_2258 7960471 200 µM -0.213887749285241 0.413632699356401 no 1979 0.4153172969145 2857 2974708
SGTC_940 3232-1287 54.8 µM -0.21403623527005 0.41358027770692 no 1980 0.41525940011109 2773 1585493 YIL048W NEO1
SGTC_503 tyrphostin 8 294 µM -0.214067318749397 0.413569304157356 no 1981 0.415247280451999 2901 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1235 benzylparaben 21.5 µM -0.214163953695717 0.413535189090688 no 1982 0.415209602347149 2872 7180
SGTC_773 4358-1457 44.6 µM -0.215610756763017 0.413024501908697 no 1983 0.414645585164897 2922 1186886
SGTC_2928 9011484 9.79 µM -0.216074867688808 0.412860712885802 no 1984 0.414464694825802 2916 2994751
SGTC_1552 6-methylflavone 10.6 µM -0.216373986252575 0.412755159224773 no 1985 0.414348120974262 2797 689013
SGTC_910 3454-3003 490 µM -0.218605209126018 0.411967999584548 no 1986 0.413478797325127 2875 820824
SGTC_3112 9123419 49.47 µM -0.220544175633664 0.411284233342051 no 1987 0.412723686008954 2773 17015854
SGTC_112 phenothiazine 287.218 µM -0.221336912190815 0.4110047564735 no 1988 0.412415055426405 2796 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_3114 9122766 49.47 µM -0.222555944654296 0.410575078452172 no 1989 0.411940563757746 2847 17176985
SGTC_2648 atorvastatin 78.68 µM -0.222729932893465 0.410513760749851 no 1990 0.411872851702516 2898 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2505 galangin 7.89 µM -0.222915444762602 0.410448384248428 no 1991 0.411800657816964 2765 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1180 1193-0155 285 µM -0.223466187049779 0.410254311042327 no 1992 0.411586348288219 2947 2921347
SGTC_813 k007-0158 173 µM -0.223512737032028 0.410237908543164 no 1993 0.411568235570657 2877 6523916
SGTC_1301 naphtanilide LB 4.81 µM -0.223944259304824 0.410085863467227 no 1994 0.411400338122512 2933 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2275 7947463 200 µM -0.224680169889065 0.409826599629729 no 1995 0.411114046175732 2778 1225414
SGTC_3144 9087057 49.47 µM -0.225475739665234 0.409546361999168 no 1996 0.410804598209356 2786 17249618
SGTC_2172 5754775 163.918 µM -0.22594337506882 0.409381660054249 no 1997 0.410622730782799 2812 2263357
SGTC_2910 7948405 25.97 µM -0.225966582405311 0.409373486809144 no 1998 0.410613705750371 2956 2971328
SGTC_3176 9106582 49.47 µM -0.226041681838497 0.409347038284614 no 1999 0.410584500878391 2850 17018027
SGTC_1960 st011366 51.8 µM -0.226456256510826 0.409201040771868 no 2000 0.410423288878116 2783 3972846
SGTC_2670 beta-carotene 100 µM -0.226739123182421 0.409101433060165 no 2001 0.410313301692056 2917 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_3187 9109394 49.47 µM -0.226811982645764 0.409075777525842 no 2002 0.410284972853478 2841 17098090
SGTC_1222 0366-0074 1.18 µM -0.229184892289212 0.408240433633607 no 2003 0.409362607156469 2950 286520
SGTC_1256 0570-0116 285 µM -0.229362445810993 0.408177945545483 no 2004 0.409293611030854 2832 410638
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.229694777363017 0.408060991239999 no 2005 0.409164476738104 2817 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_3082 9117008 49.47 µM -0.231051143395399 0.407583743188336 no 2006 0.408637535040742 2850 41448529
SGTC_1075 aripiprazole 15.2 µM -0.231091279850041 0.407569622946672 no 2007 0.408621944731341 2805 60795 An atypical antipschotic. YIL048W NEO1
SGTC_39 0986-0283 58.349 µM -0.231106602413831 0.407564232409955 no 2008 0.408615992985435 2977 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_3203 9113543 49.47 µM -0.231182996572883 0.407537356912943 no 2009 0.408586319504521 2979 17018012
SGTC_3348 9149464 3.537 µM -0.231622431883102 0.407382771842656 no 2010 0.4084156415681 2777 1951442
SGTC_1795 st049545 62.3 µM -0.233562895632647 0.406700325997595 no 2011 0.407662168018232 2814 5291882
SGTC_691 1548-0686 185 µM -0.234732773188193 0.406289025979773 no 2012 0.407208074493857 2839 46495133
SGTC_3126 9127922 49.47 µM -0.234927554751707 0.406220555626405 no 2013 0.40713248119756 3073 45595682
SGTC_210 3551-0445 56.827 µM -0.235811054156605 0.405910020603 no 2014 0.406789645025865 2942 2865180 YOR207C RET1
SGTC_3342 9147791 14.508 µM -0.236829808006082 0.405552019430364 no 2015 0.406394412922389 2813 1838168
SGTC_3165 9101544 49.47 µM -0.236860145497102 0.405541359716078 no 2016 0.406382644757789 2931 5002184
SGTC_1815 st051655 58.2 µM -0.237521498180701 0.405308996990992 no 2017 0.406126121594735 2915 5984156
SGTC_855 0428-0020 25 µM -0.239308607438762 0.404681272866261 no 2018 0.40543314576118 2852 6812414
SGTC_829 1635-0120 117 µM -0.239477535201545 0.404621949462 no 2019 0.40536765702712 2967 285054
SGTC_2204 7233102 200 µM -0.241649940672793 0.403859248281742 no 2020 0.404525710782075 2854 2172480
SGTC_2207 7258803 200 µM -0.242130324610015 0.40369064143068 no 2021 0.404339590769787 2917 3666799
SGTC_1170 0310-0127 64.8 µM -0.242293189906895 0.40363348245408 no 2022 0.404276495130592 2908 774975
SGTC_2081 5214970 32.255 µM -0.242360712273634 0.403609785502227 no 2023 0.404250337022768 2929 2063512
SGTC_3214 9129694 49.47 µM -0.243177956088921 0.403323002143912 no 2024 0.403933771436517 2981 17158655
SGTC_1510 1123-0200 71.5 µM -0.243210998390397 0.40331140818715 no 2025 0.403920973572371 3030 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2642 cholecalciferol 100 µM -0.243337726560194 0.403266942311158 no 2026 0.403871890478474 2929 9821465 A vitamin D precursor, similar to steriods.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.243939936749447 0.403055658297985 no 2027 0.403638669117796 2843 16623 A steroid.
SGTC_1990 st072050 59.8 µM -0.244532532262194 0.402847775197771 no 2028 0.403409204729444 2800 17233948
SGTC_1441 4106-0040 13 µM -0.245314836985156 0.402573383980308 no 2029 0.403106332214828 2835 2904180
SGTC_91 0417-1751 58.384 µM -0.24558990751382 0.402476915149563 no 2030 0.402999851321577 2806 6795624
SGTC_1854 st056233 32.9 µM -0.246228835196754 0.402252862429437 no 2031 0.402752547650986 2877 5393174
SGTC_1770 st043884 66.3 µM -0.246361346769527 0.402206398624699 no 2032 0.402701262522685 2826 670149
SGTC_3298 9116858 71.43 µM -0.247660788159159 0.401750836328428 no 2033 0.40219843665743 2989 2506942
SGTC_2828 7998861 71.43 µM -0.248599725344317 0.40142174377242 no 2034 0.401835210486131 2958 2988188
SGTC_2955 9076254 12.21 µM -0.24971060561995 0.401032476367644 no 2035 0.401405577943448 2965 16459619
SGTC_143 4032-1194 15.74 µM -0.25027961370424 0.400833126293267 no 2036 0.401185560392845 2771 1806963
SGTC_1783 st039459 87.517 µM -0.251131550131349 0.400534701509449 no 2037 0.400856201932742 3065 729761
SGTC_203 k066-0004 30.888 µM -0.252035194800223 0.400218227292324 no 2038 0.400506930083729 2858 6795412
SGTC_2263 7948595 193.29 µM -0.25284472682413 0.399934768807149 no 2039 0.400194101680795 2848 2971371
SGTC_2181 6316240 54.2555 µM -0.254970558024037 0.399190658138209 no 2040 0.399372919568121 2944 12779990
SGTC_2639 lactacystin 53 µM -0.257563245728872 0.398283628174297 no 2041 0.398371999240751 3004 3870 A proteasome inhibitor.
SGTC_2737 bleomycin 30.5 nM -0.261918942062147 0.396761063334275 no 2042 0.396691967809955 2885 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2109 5483026 200 µM -0.265683400319176 0.395446435854757 no 2043 0.395241524341299 2912 759335
SGTC_2043 5101342 149 µM -0.26641863840161 0.39518981366096 no 2044 0.394958406208238 2908 678451
SGTC_2472 5377652 49.4 µM -0.267692716998944 0.394745226142697 no 2045 0.394467928140423 2922 1610903
SGTC_1469 k284-2957 126 µM -0.268548625618324 0.394446635227387 no 2046 0.394138525541146 2918 23884841
SGTC_529 4076-0302 30.3 µM -0.269302137787973 0.394183817492753 no 2047 0.393848593607708 2890 5816522
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.270582260870544 0.393737433477895 no 2048 0.393356170403185 2936 75037 A free radical scavenger.
SGTC_992 3909-8734 162 µM -0.271080080227883 0.393563879553328 no 2049 0.39316472092148 2924 4288319
SGTC_1812 st052057 4.327 µM -0.271271580103669 0.393497122903228 no 2050 0.393091081502971 2852 3645418
SGTC_1968 st069590 43.6 µM -0.271772992069107 0.393322346067419 no 2051 0.392898286525637 3032 6384066
SGTC_1558 st069300 45.6 µM -0.272321512806957 0.393131173179324 no 2052 0.392687408120434 2986 24208000
SGTC_1165 k072-0275 30.3 µM -0.27515660724876 0.39214348521023 no 2053 0.391597961510597 2982 6153523 YGL055W OLE1
SGTC_2166 5933061 31.504 µM -0.27561330242423 0.391984446888407 no 2054 0.391422545706627 3376 2877375
SGTC_1210 3013-0140 750 nM -0.276063332558146 0.391827747234708 no 2055 0.391249711530543 3023 905973
SGTC_2768 sulfasalazine 50.2 µM -0.279215855425022 0.390730537968862 no 2056 0.390039588230911 3020 5384001 An antioxidant and salicylic acid derivative.
SGTC_3058 9093861 49.47 µM -0.280235963918909 0.390375683480755 no 2057 0.389648238191195 3080 17217477
SGTC_2981 9013952 38.96 µM -0.280772742868481 0.390188996437033 no 2058 0.389442355513699 2964 2996344
SGTC_502 l-744,832 89.3 µM -0.281007911124178 0.390107214940088 no 2059 0.389352166013328 3015 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1465 k213-0056 144 µM -0.282448210680207 0.389606446373022 no 2060 0.388799926179757 2881 24048857 YMR208W ERG12
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.282746683339051 0.389502695209761 no 2061 0.388685513817095 3103 688751
SGTC_345 1362-0200 395 µM -0.283759637093025 0.389150644226227 no 2062 0.388297294239282 2918 1419823
SGTC_883 0850-0245 24.6 µM -0.285052225721261 0.388701538596225 no 2063 0.38780206527432 3114 6823229 YPR165W RHO1
SGTC_835 0312-0010 67.2 µM -0.28874243750372 0.387420206970807 no 2064 0.386389242378565 2892 1626196
SGTC_136 0097-0015 404.482 µM -0.290064754109498 0.386961363848845 no 2065 0.385883349643314 2942 4861337
SGTC_3234 9132280 49.47 µM -0.290214136411203 0.386909538190495 no 2066 0.385826211047598 3003 17612295
SGTC_3188 9110789 49.47 µM -0.292022536719194 0.386282304553669 no 2067 0.385134696405784 3091 849217
SGTC_1474 0330-0125 5.35 µM -0.29231920262498 0.386179435946673 no 2068 0.3850212890603 2959 X1474
SGTC_2794 7785382 27.27 µM -0.292436987550036 0.386138596359829 no 2069 0.384976265798577 2977 2205081
SGTC_1307 1187-1599 12.2 µM -0.292873347036864 0.385987308359605 no 2070 0.384809480999896 2916 1538471
SGTC_1759 st043059 70 µM -0.293349572248864 0.385822218500486 no 2071 0.384627483095798 2914 669426
SGTC_324 1315-0088 19.6 µM -0.294001356639465 0.385596302219113 no 2072 0.384378433357333 2996 6787421
SGTC_700 3453-2283 142 µM -0.294235098420016 0.385515293966331 no 2073 0.3842891311949 3105 565664
SGTC_2053 5265679 138 µM -0.295498574427311 0.385077495660217 no 2074 0.383806520594558 2910 764595
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.295847995373077 0.384956446059974 no 2075 0.383673083860922 2941 115019
SGTC_1153 4055-0057 267 µM -0.296936565768081 0.38457940546655 no 2076 0.383257469513873 2917 882706
SGTC_1255 0566-0045 221 µM -0.300799578027722 0.383242283874895 no 2077 0.381783665097944 3086 2788469
SGTC_1498 4478-3555 97.6 µM -0.301502715724809 0.382999052735487 no 2078 0.381515589724613 2942 3437919
SGTC_884 0851-0618 334 µM -0.302951634666041 0.382497984647089 no 2079 0.38096336020615 3076 9642473
SGTC_1137 ixabepilone 100 µM -0.305032973886561 0.381778556016687 no 2080 0.380170519390995 2910 154225 A novel microtubule stabilizer.
SGTC_189 3970-0742 2.116 µM -0.306483367227987 0.381277459133041 no 2081 0.37961832097747 2974 2891807
SGTC_1882 5615643 20 µM -0.306561289137038 0.381250543491187 no 2082 0.379588661234912 2983 2253075
SGTC_1772 st048439 82.2 µM -0.306896641476239 0.381134713262776 no 2083 0.37946102275765 3028 2927068 YDL195W SEC31
SGTC_12 0849-0099 9.267 µM -0.308597998157792 0.380547231303447 no 2084 0.378813671913232 3012 6071388
SGTC_2455 5377712 9.75 µM -0.308966409358402 0.380420054382636 no 2085 0.378673539477593 3022 2243908
SGTC_1484 3473-2379 286 µM -0.309805887695522 0.380130311625781 no 2086 0.378354287012156 2988 671917
SGTC_3230 9131665 49.47 µM -0.310466153536514 0.379902470624745 no 2087 0.378103247130381 2944 15943720
SGTC_1938 st074717 56.4 µM -0.312893482256502 0.379065219856267 no 2088 0.377180794772333 2894 17250979
SGTC_237 nikkomycin 200 µM -0.314018652049621 0.378677310718914 no 2089 0.376753436247869 3097 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1605 st000082 49.1 µM -0.314285158307244 0.378585448948783 no 2090 0.376652234758032 3080 1114022
SGTC_2208 7283366 200 µM -0.315654694026334 0.378113493388863 no 2091 0.376132309306213 3048 898663
SGTC_1310 1188-0297 994 nM -0.316055068017251 0.377975554866161 no 2092 0.375980355222339 2998 1588352
SGTC_1679 SEC14.276 6.7 µM -0.316181123983286 0.377932128756182 no 2093 0.375932517135209 3087 1005053 YMR079W SEC14
SGTC_961 1252-1571 372 µM -0.31763052504306 0.377432923006141 no 2094 0.375382608346862 3146 6813498
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.317789743900372 0.377378096977925 no 2095 0.375322215460779 3044 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.318383289681173 0.377173734946823 no 2096 0.375097106110456 3076 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_3167 9103034 49.47 µM -0.321389509730451 0.376139201398022 no 2097 0.373957615913859 2985 5127859
SGTC_3171 9103192 49.47 µM -0.322293098786088 0.375828421879517 no 2098 0.373615330409695 3063 13018434
SGTC_129 0088-0017 176.636 µM -0.323838140349115 0.37529720849411 no 2099 0.373030289502835 3112 182446
SGTC_263 alizarin 107.927 µM -0.32421447831982 0.375167852420581 no 2100 0.372887830745607 3021 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_164 4100-3994 89.624 µM -0.324622408296704 0.375027653298386 no 2101 0.372733432800006 3094 4615967
SGTC_2155 5570423 76 µM -0.32484380243618 0.374951570522922 no 2102 0.372649645602642 2991 797402
SGTC_224 benfluorex 43.875 µM -0.325216463222866 0.374823515490163 no 2103 0.372508624752218 3081 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1876 myriocin 605 nM -0.325323408473779 0.374786769128274 no 2104 0.372468158100094 3157 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_577 r071-0003 38.6 µM -0.325777811286982 0.374630649114234 no 2105 0.372296233859568 2982 4568517 YMR134W ERG29
SGTC_1660 st012960 28.1 µM -0.326806303130782 0.374277364193377 no 2106 0.371907195887671 3072 24207266
SGTC_2080 5212524 12.4 µM -0.328343796845513 0.37374943502829 no 2107 0.371325866467817 3073 260183
SGTC_2373 9071805 200 µM -0.332262116314948 0.372405074550089 no 2108 0.369845671623891 3147 10149009
SGTC_1424 4048-1941 275 µM -0.333359371928376 0.372028888010389 no 2109 0.369431513695368 3130 X1424
SGTC_49 0717-0965 32.132 µM -0.334188658757754 0.371744653728987 no 2110 0.36911860076178 3264 5889349 YGL099W LSG1
SGTC_1936 st074407 74.3 µM -0.334400862957268 0.371671932932029 no 2111 0.369038544153504 3000 809813
SGTC_3035 9091303 49.47 µM -0.334927424808578 0.37149150389537 no 2112 0.368839916851799 3011 25237002
SGTC_2881 9058953 51.95 µM -0.335241512058318 0.371383893777243 no 2113 0.368721454941672 2958 17122249
SGTC_1356 1502-0781 85.8 µM -0.33627418568763 0.371030158111778 no 2114 0.368332057222547 2998 567702
SGTC_2698 st077697 67.5 µM -0.339977534080085 0.369762497936242 no 2115 0.366936723250002 3047 3154499
SGTC_2638 epoxomicin 18 µM -0.341133136795268 0.369367222688439 no 2116 0.366501678122307 3115 9915668 A protesome inhibitor.
SGTC_1495 4469-0029 237 µM -0.341433622604198 0.369264463768529 no 2117 0.366388583501699 2991 793680
SGTC_867 0518-0118 155 µM -0.342898246243222 0.368763731552779 no 2118 0.365837505583609 3103 6848158
SGTC_1612 st002233 45.4 µM -0.343814072854891 0.368450737681884 no 2119 0.365493058054697 3078 1035021
SGTC_297 0986-0032 24 µM -0.344854753859553 0.368095179372488 no 2120 0.365101783725597 2972 2847425
SGTC_1382 3002-2117 298 µM -0.346751011462 0.367447596024053 no 2121 0.364389191703293 3167 1497314
SGTC_316 k060-0003 58.6 µM -0.348529410875651 0.366840604266693 no 2122 0.363721315036678 3142 6152314
SGTC_2700 st077718 96.8 µM -0.34872539497247 0.366773732576242 no 2123 0.363647738627299 3072 904970
SGTC_1698 5-fluorocytosine 1.055 µM -0.349543077504765 0.366494774944687 no 2124 0.36334081828462 3151 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1315 1237-0019 3.69 µM -0.349899923713007 0.366373056669371 no 2125 0.363206902142648 3148 825140
SGTC_596 1155-0152 116 µM -0.349974324327202 0.366347680722798 no 2126 0.363178983416039 3045 280313
SGTC_1289 0976-0073 69.1 µM -0.350389792628496 0.366205986974487 no 2127 0.363023092883829 3132 3391136
SGTC_758 0868-0029 16 µM -0.350431889687459 0.366191630963845 no 2128 0.363007298641441 3130 762687
SGTC_2481 5478948 45.16 µM -0.350752035700655 0.366082460355438 no 2129 0.362887191849021 3161 77792
SGTC_1625 st003711 30.1 µM -0.351323871561972 0.365887489844418 no 2130 0.362672694017927 3228 24207034 YER133W GLC7
SGTC_2740 felodipine 17.08 µM -0.351530762177233 0.365816957905763 no 2131 0.362595099163922 3099 3333 L-type calcium channel blocker
SGTC_1776 st049249 45.9 µM -0.355424350680011 0.364490426731009 no 2132 0.361135854498665 3068 1822314
SGTC_3221 9128209 49.47 µM -0.35589068387309 0.364331657143963 no 2133 0.360961216420204 3053 16460723
SGTC_1665 st014639 11.4 µM -0.357298237969523 0.363852577133263 no 2134 0.360434274473905 3071 981133 YIL048W NEO1
SGTC_2982 9019404 25.97 µM -0.358392623381187 0.363480235274583 no 2135 0.360024755611632 3040 22333232
SGTC_3018 9082602 49.47 µM -0.359707860005544 0.363032923992523 no 2136 0.359532806766941 3097 17332089
SGTC_496 calpeptin 138 µM -0.36070693356417 0.362693264392531 no 2137 0.3591592704797 3092 73364 A calpain inhibitor.
SGTC_411 enrofloxacin 100 µM -0.362513515703549 0.362079346825808 no 2138 0.358484162674412 3206 71188 A bacterial gyrase inhibitor.
SGTC_19 0279-0214 38.434 µM -0.363695406915113 0.361677905194898 no 2139 0.358042736783923 3055 3566274 YBR002C RER2
SGTC_2101 5377231 179.231 µM -0.363977893160761 0.361581978324182 no 2140 0.357937258744789 3166 2844213
SGTC_2309 7664088 163.95 µM -0.364423142481128 0.361430797921628 no 2141 0.357771028333327 3226 704922
SGTC_2041 5107442 45.335 µM -0.364941810478055 0.361254716146762 no 2142 0.357577421632958 3205 793005
SGTC_2551 apiole 73.87 µM -0.365491404490459 0.361068167418727 no 2143 0.357372310956813 2995 10659 A possible DNA adduct former.
SGTC_2431 5490079 200 µM -0.365696287204968 0.360998632518696 no 2144 0.357295858449678 3101 5722345
SGTC_2716 st080858 38.6235 µM -0.36763488316864 0.360340922400429 no 2145 0.356572750321721 3188 5296050
SGTC_1040 k898-0338 155 µM -0.368918861233708 0.359905532658762 no 2146 0.356094102121656 3247 20969351
SGTC_1746 st038117 42 µM -0.368933670994298 0.359900511811206 no 2147 0.356088582581043 3132 2898218
SGTC_1758 st042942 75.2445 µM -0.369191479045816 0.359813112859274 no 2148 0.355992503348128 3113 669317
SGTC_140 0062-0056 502.533 µM -0.370423309808786 0.359395613820279 no 2149 0.355533554195806 3010 3758964
SGTC_798 1287-0182 476 µM -0.371465663783098 0.359042464369985 no 2150 0.355145362843977 3232 1649755
SGTC_2695 st077686 51.995 µM -0.371475944621635 0.359038981821894 no 2151 0.355141534822768 3083 2876092
SGTC_1353 1498-1206 8.11 µM -0.373560721633815 0.358333023451298 no 2152 0.354365580592763 3109 6756808
SGTC_3245 9134821 49.47 µM -0.373723802710207 0.358277820441582 no 2153 0.354304907235667 3068 17014901
SGTC_906 1165-0455 526 µM -0.374243387829201 0.358101960428483 no 2154 0.354111623307666 3061 3252859
SGTC_2920 7982904 15.77 µM -0.376106602351559 0.357471580172787 no 2155 0.35341882305851 3143 6456808
SGTC_1319 1306-0155 43.7 µM -0.377596800935044 0.356967681825533 no 2156 0.35286507077091 3087 3122360
SGTC_3356 9151811 4.48 µM -0.38073712906991 0.355906623321901 no 2157 0.351699157600426 3050 1859254 YPR165W RHO1
SGTC_1043 0916-0009 19.3 µM -0.381612909395679 0.355610911944932 no 2158 0.351374253672692 3250 3101130
SGTC_623 k072-0108 16.9 µM -0.382324479871544 0.355370710765899 no 2159 0.351110349548281 3140 5382803
SGTC_1730 st033808 45.1 µM -0.383292394223984 0.355044069128092 no 2160 0.350751488992789 3068 1045166
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.384034637458486 0.354793656759711 no 2161 0.350476387636172 3041 2333 A French combination drug.
SGTC_1735 st034310 56.75 µM -0.384225093885653 0.354729412129423 no 2162 0.350405810444492 3249 871153
SGTC_2137 5261020 140 µM -0.384973371591078 0.354477043629406 no 2163 0.350128572169484 3063 763655
SGTC_578 3460-0051 92 µM -0.385105428252051 0.354432512058282 no 2164 0.350079653218029 3216 2876744
SGTC_3249 9135183 49.47 µM -0.385276180365792 0.354374934725421 no 2165 0.350016403645735 3231 4902779
SGTC_1827 berberine 7.24 µM -0.386609761669991 0.353925367886682 no 2166 0.349522565053425 3080 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2647 atorvastatin 60.16 µM -0.387350518981716 0.353675737292908 no 2167 0.349248365074584 3151 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_511 blebbistatin 171 µM -0.391038941192979 0.352433700347373 no 2168 0.347884226022689 3246 3476986 A myosin inhibitor.
SGTC_2341 7987486 176.74 µM -0.391051338064992 0.352429528475788 no 2169 0.347879644426272 3245 1258686
SGTC_1871 st057448 67.3 µM -0.391261981093223 0.35235864430292 no 2170 0.347801799043247 3297 691747
SGTC_3195 9113082 49.47 µM -0.391731660895976 0.352200609287059 no 2171 0.347628246955762 3191 17018038
SGTC_219 mitoxanthrone 164.414 µM -0.391801007890932 0.352177277991595 no 2172 0.347602625148104 3119 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_744 1594-0068 283 µM -0.392266585556949 0.352020652160324 no 2173 0.347430625034491 3106 668392
SGTC_1405 3909-7894 12 µM -0.392862947724016 0.351820065550146 no 2174 0.347210354597246 3179 7104060
SGTC_2899 9053889 58.44 µM -0.393066248428941 0.351751694713873 no 2175 0.347135275884558 3195 6470052
SGTC_513 4245-1575 41.7 µM -0.394079005298461 0.351411172015173 no 2176 0.346761355391478 3166 719745
SGTC_1714 st033236 13.627 µM -0.394949978412234 0.351118417095269 no 2177 0.346439902274837 3274 2916566
SGTC_360 0957-0399 1.01 µM -0.395347979683146 0.350984668732402 no 2178 0.34629304733409 3227 6752301 YPR165W RHO1
SGTC_3300 9124615 50.48 µM -0.396745970049547 0.350515020338028 no 2179 0.345777398578864 3277 24824903
SGTC_1271 0832-2808 169 µM -0.397903637594899 0.350126280130825 no 2180 0.345350609281352 3240 3663794
SGTC_2106 5357045 167.29 µM -0.398037590832554 0.35008130928685 no 2181 0.345301238344531 3187 668842
SGTC_794 k038-0031 316 µM -0.398755758404837 0.349840241596477 no 2182 0.345036589343679 3208 6624242
SGTC_1323 1348-1351 11.2 µM -0.399646408342352 0.349541360732938 no 2183 0.344708484845515 3117 6989654
SGTC_1232 0279-0259 161 µM -0.400827029821129 0.349145316088288 no 2184 0.344273738408329 3144 1560000
SGTC_1183 1254-0324 198 µM -0.401771338639222 0.34882866175062 no 2185 0.343926158646729 3225 5799357
SGTC_3322 9139058 2.11 µM -0.402169635790172 0.3486951326287 no 2186 0.343779593552044 3278 4908926 YPR165W RHO1
SGTC_379 3970-0972 5.9 µM -0.403218897182249 0.348343457495391 no 2187 0.34339359954184 3163 2898042 YBL034C STU1
SGTC_1720 st037298 9.481 µM -0.404505232107447 0.347912501593189 no 2188 0.342920615601164 3204 597396
SGTC_1395 3486-0190 4.35 µM -0.404767277689861 0.34782473351818 no 2189 0.342824291873434 3288 6748079
SGTC_110 0850-0284 111.64 µM -0.40779795607285 0.346810248668673 no 2190 0.341711007158545 3016 3906265
SGTC_2592 piperlongumine 83.33 µM -0.408454820719046 0.34659051519642 no 2191 0.341469896532681 3173 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_119 0121-0043 24.815 µM -0.409446895194353 0.346258745630426 no 2192 0.341105865466402 3186 1092378
SGTC_821 1114-0266 29.2 µM -0.409722172238265 0.346166708368546 no 2193 0.341004881703357 3205 3123235
SGTC_3186 9110464 49.47 µM -0.409991718205032 0.346076596061933 no 2194 0.340906011388006 3245 17018021
SGTC_202 3594-0513 34.79 µM -0.41099310318023 0.34574189795358 no 2195 0.340538795943369 3148 708429
SGTC_2524 avocatin b 10.57 µM -0.411842369376606 0.345458137734316 no 2196 0.340227482007473 3191 6710748
SGTC_2342 7990637 118.86 µM -0.41197342217181 0.34541435757947 no 2197 0.340179451918519 3228 2033102 YER133W GLC7
SGTC_2097 5376186 200 µM -0.418759282859754 0.343150276791995 no 2198 0.337696032489376 3238 742755
SGTC_819 1013-0258 27.7 µM -0.41918969563721 0.343006859608541 no 2199 0.33753875112284 3151 5753198
SGTC_2292 7671323 168.05 µM -0.419954430858067 0.342752099151632 no 2200 0.337259371714098 3279 937504
SGTC_1695 st026914 34.495 µM -0.41997497633636 0.342745255708972 no 2201 0.33725186710654 3125 3289191
SGTC_1488 4013-0813 75.9 µM -0.420045684349688 0.34272170414573 no 2202 0.337226040220678 3156 2910057
SGTC_288 1315-0019 35.1 µM -0.420798532656534 0.342470981880493 no 2203 0.336951101612854 3251 6811474
SGTC_533 1222-0222 6.71 µM -0.422472615468003 0.341913708299122 no 2204 0.336340042433419 3300 3982874
SGTC_2626 ethyl orsellinate 100 µM -0.42323757437196 0.341659181056277 no 2205 0.336060967494735 3119 75653 A natural product.
SGTC_3098 9119039 49.47 µM -0.423756197508353 0.341486658840455 no 2206 0.335871812995635 3219 17161528
SGTC_3059 1327-0034 3 µM -0.426628978580528 0.340531616472429 no 2207 0.33482479366782 3139 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1329 1447-1697 50.6 µM -0.428766789428213 0.339821574029142 no 2208 0.334046474884644 3227 2840515
SGTC_268 camptothecin 39.6153 µM -0.428995765080626 0.339745556761643 no 2209 0.333963153305699 3255 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_59 0330-0160 1.33 µM -0.429054968005179 0.339725903135888 no 2210 0.333941611380922 3255 4293482
SGTC_279 1273-0055 2.93 µM -0.429078179980238 0.339718197563323 no 2211 0.333933165484304 3220 2847562
SGTC_2921 7974240 10.71 µM -0.429559853866821 0.339558313620415 no 2212 0.333757922875305 3265 2979074 YDR527W RBA50
SGTC_729 4092-0585 94.1 µM -0.432362617062236 0.338628554730164 no 2213 0.33273894178893 3134 2169061
SGTC_2763 lisinopril 49.32 µM -0.432737218891315 0.338504362617686 no 2214 0.332602843761091 3256 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_815 1582-0027 36.9 µM -0.433804442309454 0.338150641314044 no 2215 0.332215227729484 3260 3128206
SGTC_2746 daunorubicin 9.88 µM -0.434099769541247 0.33805278305827 no 2216 0.332107996422302 3195 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_759 3486-0358 89.3 µM -0.434519091366657 0.337913857330123 no 2217 0.331955767139315 3324 875103
SGTC_2782 7736369 71.43 µM -0.435405930038686 0.337620111091145 no 2218 0.331633903385028 3179 2950836 YOL077C BRX1
SGTC_682 0kpi-0099 17 µM -0.436581926982565 0.337230739942424 no 2219 0.331207285983252 3265 1714895 YML126C ERG13
SGTC_3086 9117350 49.47 µM -0.436870372334637 0.337135262639437 no 2220 0.33110267984362 3218 2679265
SGTC_1430 4049-0248 69.1 µM -0.437566063610738 0.336905027434309 no 2221 0.330850438193135 3270 22774488
SGTC_2513 baicalein 25.65 µM -0.439082860070003 0.336403263890766 no 2222 0.330300748997539 3211 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_3297 9117502 71.43 µM -0.43957951189512 0.336239032330443 no 2223 0.330120841153806 3268 7453720
SGTC_2598 perillyl alcohol 100 µM -0.439709528765592 0.336196043842597 no 2224 0.33007375014773 3315 10819 An apoptosis inducer.
SGTC_2742 clothiapine 36.27 µM -0.442884618074257 0.335146905428706 no 2225 0.328924596933487 3239 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_3060 1327-0027 12.5 µM -0.443288043526101 0.33501369418727 no 2226 0.328778701460054 3214 16000455 YPR107C YTH1
SGTC_1981 st071826 47 µM -0.444067700409287 0.334756309998572 no 2227 0.328496818951167 3244 11838600
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.445275268934794 0.334357814733772 no 2228 0.328060418980288 3148 279621
SGTC_1081 sertraline 6 µM -0.445470596567054 0.334293374514867 no 2229 0.327989852076127 3291 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2154 5570129 200 µM -0.445593440943465 0.334252849629213 no 2230 0.327945474673134 3273 673366
SGTC_1061 3448-9325 110 µM -0.445986487519579 0.334123201261137 no 2231 0.327803503329099 3276 723482
SGTC_2918 7977171 22.06 µM -0.447543188046979 0.333609910386538 no 2232 0.327241456152963 3221 2236483
SGTC_2862 9027634 71.43 µM -0.450801199120901 0.332536654786892 no 2233 0.326066418498805 3153 5012562
SGTC_3139 9095020 49.47 µM -0.452605132985042 0.331942991250399 no 2234 0.325416550981209 3186 25236292
SGTC_2708 st078559 56 µM -0.454841710278827 0.331207532976547 no 2235 0.324611560210788 3296 17250902
SGTC_1056 3448-1962 115 µM -0.455397430890806 0.331024895040336 no 2236 0.324411671609793 3272 715507
SGTC_198 3454-2873 16.191 µM -0.456024236208745 0.330818943313934 no 2237 0.32418627506627 3224 710957
SGTC_2665 lovastatin 100 µM -0.456293522446998 0.330730478663996 no 2238 0.324089460651181 3255 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1207 2099-0101 141 µM -0.456729604050743 0.330587239236232 no 2239 0.323932704809359 3297 5837381
SGTC_1851 st056236 18.9 µM -0.456831835114885 0.330553663057257 no 2240 0.32389596089047 3356 5393171
SGTC_2328 6201408 200 µM -0.456955050279134 0.330513196794237 no 2241 0.323851677140706 3295 2890418
SGTC_514 4466-0038 2.65 nM -0.4571042440455 0.330464201303743 no 2242 0.323798059972273 3207 5722064
SGTC_2629 bisabolol 100 µM -0.458540415602179 0.329992708804848 no 2243 0.323282116625212 3338 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_3083 9117465 49.47 µM -0.459107994836061 0.329806447953424 no 2244 0.323078307888415 3274 16420915
SGTC_2307 7538926 6.34 µM -0.459674554049551 0.329620563919826 no 2245 0.322874918383329 3230 96582
SGTC_2142 5622915 118.518 µM -0.460031438375285 0.32950349432079 no 2246 0.322746827404278 3240 5322196
SGTC_1545 lovastatin 49.4 µM -0.460248447012167 0.329432316638604 no 2247 0.322668950125719 3279 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2939 9044578 71.43 µM -0.462004456111212 0.328856582484163 no 2248 0.322039062444735 3184 2653634
SGTC_2130 NSC 7 2.4545 µM -0.462487492310512 0.328698282876427 no 2249 0.321865884891677 3305 21448
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.463367638192362 0.32840992234908 no 2250 0.321550435537136 3262 3256 An antibiotic and ribosome inhibitor.
SGTC_846 0335-0850 148 µM -0.463539421352902 0.328353653270664 no 2251 0.321488882458758 3274 6819598
SGTC_1175 0741-0056 27.6 µM -0.463864685086384 0.328247120952894 no 2252 0.321372347884102 3382 765927
SGTC_2178 5812956 200 µM -0.464276270062061 0.328112336205559 no 2253 0.321224911578184 3231 5403383
SGTC_2545 solidagenone 89.61 µM -0.464321183039667 0.328097629577648 no 2254 0.32120882473733 3186 6708572 An anti ulcer agent
SGTC_2088 5278280 127.392 µM -0.464789997292038 0.327944133584456 no 2255 0.321040925814075 3322 791502
SGTC_2153 5569715 200 µM -0.465920134026828 0.327574231350087 no 2256 0.320636334415607 3278 2054701
SGTC_1169 aniline yellow 25.8 µM -0.466671206994675 0.327328493084252 no 2257 0.320367566448867 3230 6051 A DNA damaging agent.
SGTC_1924 st058459 75.1 µM -0.467021070421088 0.327214049272165 no 2258 0.320242401598388 3301 688683
SGTC_1662 st014054 52 µM -0.467036988284911 0.327208842766553 no 2259 0.320236707413841 3249 2838777
SGTC_3076 9116187 49.47 µM -0.4682412828607 0.326815032791077 no 2260 0.319806026490336 3302 27241210
SGTC_3323 9138564 53.9225 µM -0.468583822629804 0.326703055885434 no 2261 0.319683571434892 3363 43912313 YNL103W MET4
SGTC_2704 st078022 71.1 µM -0.468831883276236 0.32662197412949 no 2262 0.319594904131835 3362 54697681
SGTC_57 miconazole 162.5 nM -0.468886420925565 0.326604148907823 no 2263 0.31957541146586 3270 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1236 0330-0013 258 µM -0.468954246931124 0.326581981038864 no 2264 0.319551170015055 3226 4617066
SGTC_587 k089-0003 57 µM -0.469126197077066 0.326525784567411 no 2265 0.319489717381835 3305 9659696
SGTC_2456 5770359 74.46 µM -0.469565757585221 0.326382146002043 no 2266 0.319332646996372 3351 3118787
SGTC_46 0329-0187a 2.197 µM -0.472665189324913 0.325370052625139 no 2267 0.318226032838297 3296 46494817
SGTC_2345 9052315 157.45 µM -0.475036302584579 0.324596653588873 no 2268 0.317380549151441 3311 6469265
SGTC_2760 etidronate 98.04 µM -0.475070485081941 0.324585509614272 no 2269 0.317368367420772 3220 3305 A chelator and antioxidant.
SGTC_2124 5246320 200 µM -0.47697059571393 0.323966294082179 no 2270 0.316691530090474 3322 579342
SGTC_1602 st001878 87.6 µM -0.478398551918264 0.323501266346449 no 2271 0.316183282049328 3365 595405 YLR310C CDC25
SGTC_837 0091-0265 12.5 µM -0.478413589672311 0.323496370621389 no 2272 0.316177931553376 3220 759367
SGTC_1673 st016611 27.3 µM -0.479117744596567 0.323267158584278 no 2273 0.315927433396262 3362 5226799
SGTC_1959 st077091 55.8 µM -0.480586158211815 0.3227893857619 no 2274 0.315405327531305 3214 821356 YKL052C ASK1
SGTC_1418 3966-3099 2.4 µM -0.481050574421887 0.322638341030864 no 2275 0.315240277365344 3339 740335
SGTC_2584 androsterone 48.74 µM -0.482245625244183 0.322249802420049 no 2276 0.31481573450486 3339 2754130 A steroid.
SGTC_1863 st057641 20.1 µM -0.484347152957675 0.321567018293156 no 2277 0.314069758475293 3346 3921635
SGTC_3101 9120531 49.47 µM -0.485467170572837 0.321203371647012 no 2278 0.313672497417438 3437 24824904
SGTC_1916 st067606 49.2 µM -0.486231414388119 0.320955335759925 no 2279 0.313401550330976 3289 19590279
SGTC_1494 4358-1428 177 µM -0.488078637898164 0.320356148064235 no 2280 0.312747070784686 3388 1564571
SGTC_2069 5228469 200 µM -0.490611214816676 0.319535411745953 no 2281 0.311850726448177 3339 2835210
SGTC_2076 5212012 200 µM -0.492123076163788 0.31904588106693 no 2282 0.31131616995969 3284 604802
SGTC_1118 chelidonine 707.474 nM -0.492370903850248 0.318965666173673 no 2283 0.311228582169461 3368 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_979 1426-2828 121 µM -0.492657282718935 0.318872983899427 no 2284 0.311127382848394 3390 747872
SGTC_820 1582-0060 59.9 µM -0.492796349164719 0.318827981191295 no 2285 0.311078245301025 3261 3848840
SGTC_291 SEC14.278 35.5 µM -0.493913977879189 0.318466407104999 no 2286 0.310683466239967 3367 1068044
SGTC_752 1896-0090 130 µM -0.495458856413387 0.317966894201179 no 2287 0.310138128868351 3343 772567
SGTC_2157 5649910 96.377 µM -0.496120839204333 0.317752953414895 no 2288 0.309904578625568 3258 2858091
SGTC_2260 7964312 200 µM -0.498533744254334 0.316973661815827 no 2289 0.309053945622216 3397 231951
SGTC_3281 9140613 49.47 µM -0.499893343244444 0.316534911645862 no 2290 0.308575089872674 3319 16013766
SGTC_1913 st060213 96.1 µM -0.500004521758411 0.316499045125151 no 2291 0.308535946773434 3424 688959
SGTC_166 k072-0058 166.424 µM -0.501488919191911 0.316020339515533 no 2292 0.308013537170999 3412 5846229
SGTC_2536 dehydroabietamide 32.04 µM -0.50169980020156 0.315952357167992 no 2293 0.30793935253597 3411 3983547
SGTC_1087 pterostilbene 9.05 µM -0.503699234915331 0.315308102883721 no 2294 0.307236373046042 3394 5281727 Similar to reservatol, lowers cholesterol.
SGTC_764 1951-2361 146 µM -0.503968064215278 0.315221523944583 no 2295 0.307141909510116 3278 5438930
SGTC_142 0335-0849 62.6745 µM -0.504225726899161 0.315138550840488 no 2296 0.30705138180594 3423 3889043 YPR107C YTH1
SGTC_3289 9119912 71.43 µM -0.504673779527781 0.314994290157266 no 2297 0.306893990140375 3401 17014829
SGTC_304 1310-0298 97 µM -0.504975661459187 0.314897108347224 no 2298 0.306787965295731 3347 1550234
SGTC_1799 st045822 46.1415 µM -0.505931026690559 0.314589641716471 no 2299 0.306452535190161 3386 3674992
SGTC_322 k048-0136 19.3 µM -0.506875212323339 0.31428589930742 no 2300 0.30612118951338 3356 6823282
SGTC_1246 0422-0085 105 µM -0.507815711725745 0.313983467717651 no 2301 0.305791295066997 3420 264295
SGTC_1562 morin hydrate 59.1 µM -0.50820585589974 0.313858047688247 no 2302 0.305654492286319 3423 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2937 9044753 11.33 µM -0.508290041385312 0.313830987318027 no 2303 0.305624976477738 3308 6465530 YGL099W LSG1
SGTC_2686 alizarin 95.37 µM -0.512547841342173 0.312463679457242 no 2304 0.304133823330136 3304 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1275 0867-0008 21.1 µM -0.513194170569363 0.31225634856313 no 2305 0.30390775164651 3255 3422836
SGTC_2652 actinonin 100 µM -0.513795683028232 0.312063447483731 no 2306 0.303697423232795 3306 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_3218 9131285 49.47 µM -0.515343571985583 0.311567286684635 no 2307 0.303156478151044 3465 17156417
SGTC_340 k038-0059 454 µM -0.515669430941775 0.311462879296839 no 2308 0.30304265423877 3376 23733424
SGTC_3205 9113483 49.47 µM -0.516810368980585 0.311097434632808 no 2309 0.302644270521743 3424 17018033
SGTC_1054 3429-0080 167 µM -0.517043847324502 0.311022674001057 no 2310 0.302562775333803 3424 1162877
SGTC_1663 st014140 55.4 µM -0.517779257374134 0.310787243948949 no 2311 0.302306146111771 3421 4207120
SGTC_3207 9114163 49.47 µM -0.518689444386558 0.310495969023691 no 2312 0.301988661894763 3515 849233
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.518798282593838 0.310461146941623 no 2313 0.301950707841211 3347 6708561
SGTC_1522 st012842 45.6 µM -0.519143736825879 0.310350632342449 no 2314 0.301830255258096 3324 3491067 YOR116C RPO31
SGTC_754 3474-0146 171 µM -0.519374415651389 0.310276845187796 no 2315 0.301749834458163 3247 24762078
SGTC_474 dl-dihydrosphingosine 5 µM -0.519477508443765 0.310243871401478 no 2316 0.301713896672013 3439 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2474 5321570 43.32 µM -0.52047268160218 0.309925648013946 no 2317 0.301367081796529 3366 2841384
SGTC_1217 1183-1422 255 µM -0.520855281122881 0.30980334324046 no 2318 0.301233794786156 3404 2849664
SGTC_1002 4049-0206 172 µM -0.522772134299168 0.309190904009505 no 2319 0.300566416699177 3335 4662749
SGTC_1485 3909-9022 254 µM -0.523077887335827 0.309093264127897 no 2320 0.300460026454552 3402 714516
SGTC_3119 9125183 49.47 µM -0.523688940334098 0.308898169459117 no 2321 0.300247454603846 3275 22695334
SGTC_3306 9127676 59.7925 µM -0.524371597635024 0.308680276990587 no 2322 0.300010053633548 3365 41905287
SGTC_3248 9135562 49.47 µM -0.524905216144447 0.308510002028047 no 2323 0.299824541570279 3369 17650701
SGTC_2421 5690543 90.72 µM -0.528655631978842 0.30731442666134 no 2324 0.298522180325853 3393 3397993
SGTC_2411 st077133 39.94 µM -0.529905423233473 0.306916465873707 no 2325 0.298088752928713 3539 1403142 YNL221C POP1
SGTC_1279 0874-0590 65.2 µM -0.530267815954384 0.306801114638915 no 2326 0.297963128838223 3362 3523074
SGTC_1926 methyl fluorone black 53.6 µM -0.530972565862752 0.306576844347051 no 2327 0.297718895137098 3309 72721 Reacts with homocysteine.
SGTC_1388 3346-4487 254 µM -0.53103477357435 0.306557051664264 no 2328 0.297697341210885 3399 3345614
SGTC_571 k831-0106 44.2 µM -0.531176307861456 0.306512021676795 no 2329 0.297648304612853 3421 4783639
SGTC_2201 6605497 169.863 µM -0.535238429915802 0.305220880239954 no 2330 0.296242497723843 3378 670741
SGTC_2986 9022445 71.43 µM -0.537153120074322 0.304613135991298 no 2331 0.295580925278184 3426 6459286
SGTC_3028 9087778 49.47 µM -0.538356308076733 0.304231506158166 no 2332 0.295165542131465 3331 17217395
SGTC_214 4373-3496 70 µM -0.538637982078882 0.304142194948228 no 2333 0.295068337120983 3483 3779166
SGTC_3283 9109332 35.8195 µM -0.539658086900841 0.30381884510483 no 2334 0.294716424889504 3312 17027281
SGTC_1945 st075991 56.6 µM -0.540164737511192 0.303658305496857 no 2335 0.294541714283122 3349 1084980
SGTC_952 1185-0122 232 µM -0.540403422284522 0.303582687882079 no 2336 0.294459424104608 3386 678600
SGTC_2813 7971799 71.43 µM -0.54266775756633 0.30286574350499 no 2337 0.293679288747592 3416 2234054
SGTC_2229 7354935 190 µM -0.542965217349232 0.302771616761086 no 2338 0.293576875545908 3393 318112
SGTC_3063 1327-0034 4 µM -0.543256526351453 0.302679449040775 no 2339 0.293476596042438 3395 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_702 1488-0190 94 µM -0.543981398999406 0.302450160000488 no 2340 0.293227136525688 3433 949357
SGTC_93 0109-0045 59.227 µM -0.544254658736006 0.30236374370817 no 2341 0.293133121745221 3475 88733
SGTC_595 3909-8003 73.7 µM -0.544836682979577 0.302179719939178 no 2342 0.292932923407145 3459 699517
SGTC_3111 9122088 49.47 µM -0.545644552149964 0.301924372128188 no 2343 0.292655146608194 3329 16876704
SGTC_3116 9124943 49.47 µM -0.545984191017168 0.301817049489195 no 2344 0.292538402118594 3360 41905195 YPL160W CDC60
SGTC_81 0411-0046 9.971 µM -0.546303486433609 0.301716170825817 no 2345 0.292428670049164 3374 12925265
SGTC_3084 9116877 49.47 µM -0.547212116242905 0.30142917997934 no 2346 0.292116506528019 3387 27241325
SGTC_2585 alliin 100 µM -0.547437947753752 0.301357870135034 no 2347 0.29203894524954 3536 87310 A garlic compound which reacts with lipids.
SGTC_1740 st038286 13.222 µM -0.547611938643219 0.301302934961207 no 2348 0.291979195044487 3470 716786
SGTC_2192 5915882 198.485 µM -0.549499351794622 0.300707300854081 no 2349 0.291331404647465 3392 2876149
SGTC_2276 7947513 42.08 µM -0.550341504105945 0.300441704085877 no 2350 0.291042581054194 3368 2105100
SGTC_1409 3909-8004 61.9 µM -0.552430154010473 0.299783446513209 no 2351 0.290326837934238 3403 2119279
SGTC_196 k015-0023 18.111 µM -0.553275536381994 0.299517202131625 no 2352 0.290037374973229 3410 5211998
SGTC_923 1900-2434 73.3 µM -0.553826559717607 0.299343720783565 no 2353 0.28984877480989 3426 5910570
SGTC_3277 9138724 49.47 µM -0.555058900109948 0.29895590211797 no 2354 0.289427186844804 3350 15943418
SGTC_1509 1326-1131 80 µM -0.55536116043857 0.298860815374199 no 2355 0.289323826535072 3426 768313
SGTC_525 k781-2675 26.7 µM -0.556203771053023 0.298595814792416 no 2356 0.289035780786 3480 3651118 YDL195W SEC31
SGTC_2748 diazoxide 86.69 µM -0.557636499343514 0.298145468035794 no 2357 0.288546313714385 3392 3019 A potassium channel activatior.
SGTC_861 0443-0273 110 µM -0.557816326292413 0.29808896523448 no 2358 0.288484906514912 3432 6149169
SGTC_3117 9124945 49.47 µM -0.559481905778051 0.297565861318233 no 2359 0.287916438328447 3310 17592065
SGTC_480 am 92016 50 µM -0.559704278886295 0.29749605293445 no 2360 0.287840581639397 3415 2129 K+ channel blocker.
SGTC_253 dyclonine 31.25 µM -0.559928165970975 0.297425776831501 no 2361 0.287764218034847 3490 3180 An oral anasthetic.
SGTC_1773 st048542 73.5835 µM -0.560875862503661 0.297128387587769 no 2362 0.287441082912834 3342 3237138
SGTC_575 k072-0246 11.9 µM -0.562649156701619 0.296572289507096 no 2363 0.286836906008437 3452 6796779
SGTC_2247 cerulenin 830 nM -0.565993676784629 0.29552476098805 no 2364 0.285699039495872 3542 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1332 1480-0653 17.5 µM -0.569338656374966 0.29447879355432 no 2365 0.284563169010434 3456 5749438
SGTC_978 1416-0512 87.4 µM -0.569547389548973 0.294413579847354 no 2366 0.28449236005058 3477 6814003
SGTC_2520 obtusaquinone 4.71 µM -0.570946385666578 0.293976669035548 no 2367 0.284017993253999 3558 5967872
SGTC_1900 st060200 72.8 µM -0.573269747613976 0.29325173904013 no 2368 0.283231032777654 3448 688945
SGTC_3161 9100388 49.47 µM -0.573890988478753 0.293058041412404 no 2369 0.283020785760962 3485 25236368
SGTC_1202 1988-0068 29.6 µM -0.574631006736896 0.292827387485136 no 2370 0.282770438633686 3383 2850480
SGTC_1757 st041620 31.8375 µM -0.57470622974808 0.292803946184644 no 2371 0.282744996753558 3461 5289815
SGTC_912 3474-0017 2.18 µM -0.575220295530219 0.292643774242182 no 2372 0.282571159189932 3515 3360550
SGTC_1149 3909-7961 23.3 µM -0.575624649671132 0.292517814715548 no 2373 0.282434458056968 3446 735261
SGTC_319 1348-1596 45.5 µM -0.57564614001996 0.292511121006396 no 2374 0.282427193644984 3530 5380505
SGTC_723 4182-0001 115 µM -0.576424020346926 0.292268878570426 no 2375 0.282164306210679 3407 744821 YLR208W SEC13
SGTC_1934 st074720 32.6 µM -0.57684373331789 0.292138213054201 no 2376 0.282022511654414 3468 17250992
SGTC_1464 k208-0027 110 µM -0.577449983615596 0.291949522534878 no 2377 0.281817758497341 3528 X1464
SGTC_2856 9022925 19.48 µM -0.578469830372673 0.291632231552832 no 2378 0.281473480222889 3464 4944862
SGTC_1220 1838-0075 193 µM -0.578489696170538 0.291626052575175 no 2379 0.281466775973239 3458 5529645
SGTC_2090 5301565 104.445 µM -0.578711890361706 0.291556946349244 no 2380 0.281391795797063 3462 2056344
SGTC_1681 tripelennamine 100 µM -0.579529559424494 0.291302702947034 no 2381 0.2811159536621 3493 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_3177 9107506 49.47 µM -0.580608621536695 0.290967341295222 no 2382 0.280752130151911 3471 8897194
SGTC_2460 5552655 174.22 µM -0.581385027395269 0.290726153818177 no 2383 0.280490493113886 3484 5401989
SGTC_2879 9041815 71.43 µM -0.581482569196293 0.290695859447012 no 2384 0.280457631348021 3450 4942971
SGTC_1987 st072290 61.9 µM -0.583012073615067 0.290221021696251 no 2385 0.279942586240966 3424 54697379
SGTC_679 0422-0091 41.4 µM -0.584092461222123 0.289885832304011 no 2386 0.279579053282928 3480 627384 YHR062C RPP1
SGTC_222 nsc-310342 10.666 µM -0.584133172702171 0.289873205150451 no 2387 0.279565359010246 3475 432556
SGTC_85 0868-0259 160.055 µM -0.586600124487741 0.28910853238623 no 2388 0.278736149527882 3424 83173
SGTC_2269 7935389 174.42 µM -0.587145496735259 0.288939613303727 no 2389 0.278552996834458 3465 97605
SGTC_287 k060-0039 29.6 µM -0.587634064416328 0.288788327844793 no 2390 0.278388970647153 3516 5861974
SGTC_791 1348-1292 225 µM -0.589537279784847 0.288199351217311 no 2391 0.277750455846531 3524 5437054
SGTC_1557 sumaresinolic acid 42.3 µM -0.589793410368062 0.288120131304717 no 2392 0.27766458054511 3459 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1115 galangin 695.678 nM -0.590747536517056 0.287825115310925 no 2393 0.277344795920684 3558 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_16 erodoxin 22.806 µM -0.590942438509831 0.287764869130582 no 2394 0.277279494787006 3544 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1435 4092-0789 56.7 µM -0.593142765576757 0.287085139372857 no 2395 0.276542806090953 3516 2248285
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.593190538571004 0.287070389673554 no 2396 0.276526821924524 3487 688788
SGTC_3238 9133470 49.47 µM -0.593556161703072 0.286957517043799 no 2397 0.276404504610112 3539 3534688
SGTC_1949 st076024 69.1 µM -0.593872929171627 0.286859743795652 no 2398 0.276298553162224 3450 2921930
SGTC_617 3770-0098 35 µM -0.594027573601678 0.286812017078365 no 2399 0.276246835389049 3470 5962639
SGTC_1124 fisetin 1.16336 µM -0.595239728744345 0.286438049415845 no 2400 0.27584161868262 3465 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2953 9074162 66.49 µM -0.595620686826009 0.286320566061659 no 2401 0.275714326862865 3488 16451992
SGTC_3347 9188721 44.724 µM -0.598201163738609 0.285525377776969 no 2402 0.274852857517462 3500 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_3343 9148379 18.9835 µM -0.601726883940474 0.284440610012739 no 2403 0.273677975833157 3555 1955036
SGTC_2576 guaiol 23.12 µM -0.602963796528607 0.284060512898839 no 2404 0.273266386874896 3494 227829
SGTC_1373 2887-0003 58.5 µM -0.603981560997231 0.283747941241592 no 2405 0.272927950671543 3486 776948
SGTC_1644 st010134 20.9 µM -0.604047482688774 0.283727701322284 no 2406 0.272906036966521 3512 3818134
SGTC_325 2810-4341 181 µM -0.605379117224515 0.283318998042647 no 2407 0.272463561609193 3538 774970
SGTC_1966 st070145 16.1 µM -0.605749995113829 0.283205219040812 no 2408 0.272340389810715 3472 3748532
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.606118532593009 0.283092179754192 no 2409 0.272218022690167 3529 6708760
SGTC_959 1222-0044 107 µM -0.606445705329199 0.282991846173703 no 2410 0.272109412988578 3524 6083612
SGTC_1091 telmisartan 47.6 µM -0.610011304243733 0.281899497479371 no 2411 0.270927159664442 3595 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_141 0443-0274 32.331 µM -0.610797972167459 0.281658769525711 no 2412 0.270666668030119 3636 1627241
SGTC_207 4185-0010 4.486 µM -0.610864948604697 0.281638278671177 no 2413 0.270644495707001 3589 3761753
SGTC_464 bw-b 70c 158 µM -0.612191940873521 0.281232445287158 no 2414 0.27020538651558 3561 5353454
SGTC_1868 st057644 42.7 µM -0.613637499780082 0.280790672322313 no 2415 0.269727448763828 3502 688665
SGTC_2290 7904846 200 µM -0.615236491200529 0.280302400521121 no 2416 0.26919927605144 3525 2962154
SGTC_3200 9114385 49.47 µM -0.616075714200164 0.280046298058509 no 2417 0.268922274891551 3550 17018030 YLR208W SEC13
SGTC_413 propylparaben 100 µM -0.616346215633439 0.279963774352005 no 2418 0.268833021369276 3482 7175 A pharmaceutical preservative.
SGTC_3019 9081971 49.47 µM -0.617761550833874 0.279532180791758 no 2419 0.268366265974515 3598 16451803
SGTC_969 1313-0238 134 µM -0.618265990142853 0.279378434751073 no 2420 0.268200008359482 3518 5212874
SGTC_967 1306-0166 352 µM -0.621525039736185 0.278386113296183 no 2421 0.267127112303452 3554 4437607
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.621854097167427 0.278286016831676 no 2422 0.267018905439412 3627 688664
SGTC_2894 9048625 32.47 µM -0.624472652116094 0.277490100696052 no 2423 0.266158612554964 3633 4092861
SGTC_2289 7946404 165.07 µM -0.626526858143655 0.276866499528246 no 2424 0.265484712995043 3581 1246120 YPR165W RHO1
SGTC_264 promethazine 12.5 mM -0.626671008055573 0.276822765312938 no 2425 0.265437455929984 3615 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_684 1140-0066 328 µM -0.627504658918239 0.276569907050642 no 2426 0.26516424160549 3567 6813534
SGTC_2491 paeonol 100 µM -0.629481941541372 0.275970621990659 no 2427 0.264516793773138 3525 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1978 st071761 42 µM -0.631776655013564 0.275275928877103 no 2428 0.263766415123955 3488 5147680
SGTC_1811 st050069 61.5 µM -0.633357983364902 0.274797704839366 no 2429 0.263249948225078 3560 3877702
SGTC_2959 9079155 11 µM -0.633517603574392 0.274749455391488 no 2430 0.263197844468471 3567 16189457
SGTC_2277 7947813 106.88 µM -0.63589724662671 0.274030640776604 no 2431 0.262421698702288 3636 1246798
SGTC_2848 9016370 25.97 µM -0.63960434177095 0.272912699809925 no 2432 0.261214929534463 3599 7894410
SGTC_1519 esterone 74 µM -0.641436384491179 0.272361050779103 no 2433 0.260619600006711 3532 698 A steroid.
SGTC_2964 9083345 53.42 µM -0.642949396982222 0.271905883415615 no 2434 0.260128467714443 3527 17741579
SGTC_2035 5154463 94.595 µM -0.643515324183506 0.271735729905555 no 2435 0.259944887267494 3589 2769623
SGTC_2331 7980721 200 µM -0.645648778609819 0.271094755442409 no 2436 0.259253419811659 3561 2981221
SGTC_2508 celastrol 40.54 µM -0.646395573803912 0.270870566800101 no 2437 0.259011603086907 3550 122724 Celastrol is a natural product and antioxidant.
SGTC_1807 st050092 58.9 µM -0.647563800167687 0.270520049793824 no 2438 0.258633558544679 3542 5008496
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.650936685491765 0.269509315784665 no 2439 0.257543679402906 3578 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2885 9057732 51.95 µM -0.651443182242854 0.269357700291271 no 2440 0.257380221545395 3622 6471414
SGTC_3107 9121808 49.47 µM -0.652255619899351 0.269114593340514 no 2441 0.257118142328942 3551 662681
SGTC_2605 digitonin 300 nM -0.65363308694744 0.268702663524354 no 2442 0.25667411110848 3659 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_871 0574-0004 149 µM -0.654169940779324 0.268542203886179 no 2443 0.25650116263161 3558 9551173
SGTC_1436 4092-1007 8.32 µM -0.654251101757694 0.268517949964478 no 2444 0.256475021752636 3580 2881121
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.655416406060096 0.268169835113332 no 2445 0.25609984571575 3694 6728940
SGTC_182 3448-4371 550.524 µM -0.656029328130547 0.267986826250777 no 2446 0.25590262706444 3628 3491403
SGTC_1499 4480-0877 67.3 µM -0.6563929176211 0.267878293887957 no 2447 0.255785673098627 3548 2861909
SGTC_1907 st060210 83.7 µM -0.657283220741869 0.267612629713859 no 2448 0.255499411717542 3639 688793
SGTC_1303 1160-0052 261 µM -0.658364589965982 0.267290130625004 no 2449 0.255151941619962 3618 3562476
SGTC_1336 1486-0901 104 µM -0.658931888977693 0.26712102226971 no 2450 0.254969753600141 3586 5006114
SGTC_92 0063-0024 660.874 µM -0.659536959946248 0.266940713873119 no 2451 0.254775510163685 3661 3594437
SGTC_724 3910-0327 137 µM -0.660763831351906 0.266575300578936 no 2452 0.254381890629167 3615 2885483
SGTC_1693 xanthone 101.9 µM -0.664142307801033 0.265570358929243 no 2453 0.253299617023891 3641 7020 An insecticide.
SGTC_3326 9140064 16.379 µM -0.664938953537968 0.265333673677982 no 2454 0.253044769757239 3602 1868434
SGTC_2089 5281248 129.67 µM -0.667259551228035 0.264644829600008 no 2455 0.252303179192397 3635 2737878
SGTC_1719 st032227 49.2 µM -0.6677703163196 0.264493336788206 no 2456 0.252140108606648 3638 3125804
SGTC_1338 1486-1223 76 µM -0.669646149075266 0.263937344105579 no 2457 0.251541693894801 3635 3444526
SGTC_1564 D-Arginine 115 µM -0.670053828758239 0.263816587601201 no 2458 0.251411738180336 3591 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_3216 9129716 49.47 µM -0.670178593365093 0.26377963740988 no 2459 0.25137197416305 3592 8056934
SGTC_567 1080-0542 68.4 µM -0.67111943992365 0.263501082021905 no 2460 0.251072221865454 3573 5950415
SGTC_175 3793-3120 23.7 µM -0.671556308851456 0.263371789786689 no 2461 0.250933100399772 3625 5322297
SGTC_1633 st005664 67.9 µM -0.671788128326939 0.263303195504538 no 2462 0.250859293765208 3640 2063822
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.675225357195811 0.262287207410721 no 2463 0.249766299331047 3666 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1047 2043-3044 82 µM -0.676009725372662 0.262055642852008 no 2464 0.249517235193137 3630 669592
SGTC_608 k048-0125 159 µM -0.677680054324169 0.261562870548555 no 2465 0.248987287788913 3662 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_787 4152-0075 138 µM -0.680576921924771 0.260709380009407 no 2466 0.248069616896639 3658 9566539
SGTC_2 0422-0095 29 µM -0.681029550596721 0.26057615372011 no 2467 0.247926396164782 3541 6790840
SGTC_1614 st002383 48.6 µM -0.681199753552925 0.260526065414398 no 2468 0.247872551976881 3642 1947235
SGTC_1380 2291-0730 164 µM -0.681780383615176 0.260355231566847 no 2469 0.247688914986485 3641 2999191
SGTC_1105 epirubicin 18.1 µM -0.684015377947039 0.259698187179868 no 2470 0.246982727637657 3621 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2366 9070441 60.58 µM -0.684038493847595 0.259691396033986 no 2471 0.246975429379151 3647 6837235
SGTC_2175 5807670 165.306 µM -0.684300013950648 0.259614571271375 no 2472 0.246892869087217 3610 241186
SGTC_956 1185-0240 191 µM -0.684806330900847 0.259465867764251 no 2473 0.246733069924274 3659 1416193
SGTC_2923 7992654 58.14 µM -0.685504975221329 0.259260750640845 no 2474 0.246512661104464 3669 2985126
SGTC_333 3486-0131 40.1 µM -0.685755320226139 0.259187271484358 no 2475 0.246433707760014 3716 6744690
SGTC_1406 3909-7906 11.9 µM -0.686893553594485 0.258853322605592 no 2476 0.24607490476251 3661 X1406
SGTC_1352 1496-0991 99 µM -0.689719377039873 0.258025211318422 no 2477 0.245185338958688 3649 3000039
SGTC_44 0929-0055 61.211 µM -0.69161550424251 0.257470320064888 no 2478 0.244589411228147 3612 1379590
SGTC_2313 7726885 200 µM -0.692679443027201 0.257159235931316 no 2479 0.24425537130552 3650 726423
SGTC_1194 1488-0194 225 µM -0.694795237657659 0.256541181849496 no 2480 0.243591816564317 3635 1391452
SGTC_262 fenpropimorph 62.5 µM -0.696330464383558 0.256093204900045 no 2481 0.243110949465772 3629 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2238 6671620 73.2395 µM -0.696382747829493 0.256077955852937 no 2482 0.243094582172924 3635 729941
SGTC_21 0849-0113 22.993 µM -0.698084335729315 0.255581927508101 no 2483 0.242562226804705 3649 1560156
SGTC_2020 4017018 200 µM -0.698229931423377 0.255539508359398 no 2484 0.242516705368685 3716 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1073 triclabendazole 3.09 µM -0.700051809098262 0.255009017370288 no 2485 0.241947474921712 3746 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_600 1495-0418 41.6 µM -0.703079769608889 0.254128617623577 no 2486 0.241003019425 3685 5377768
SGTC_3225 9130819 49.47 µM -0.705435799320755 0.25344469068455 no 2487 0.240269536005588 3687 4547121
SGTC_2747 doxorubicin 7.63 µM -0.706400681645196 0.253164876455981 no 2488 0.239969498550687 3582 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1041 0206-0046 107 µM -0.707673611302544 0.252795977739369 no 2489 0.239573984224539 3713 50494
SGTC_2779 methotrexate 400 µM -0.709680131722365 0.252215057437227 no 2490 0.238951257800455 3744 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2125 5246583 200 µM -0.709730150835794 0.252200585088808 no 2491 0.238935745613441 3709 835267
SGTC_2640 pentamidine 10.38 µM -0.710375868999104 0.252013794669601 no 2492 0.238735541593038 3719 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3003 9075612 71.4286 µM -0.712551651410466 0.251384931989092 no 2493 0.238061619418268 3695 6501993
SGTC_2974 9094440 9.66 µM -0.714057658574169 0.250950139559623 no 2494 0.237595763303395 3772 25236134
SGTC_936 3005-4620 401 µM -0.714621888374652 0.250787345902485 no 2495 0.237421357912778 3707 777207
SGTC_450 aminopyrene 156 nM -0.714906080329645 0.250705370973662 no 2496 0.237333539815724 3648 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2112 5488546 200 µM -0.715496359404608 0.250535150831094 no 2497 0.237151194815058 3690 600757
SGTC_1277 0873-0036 22 µM -0.715970857564969 0.250398363108443 no 2498 0.237004671889583 3738 5965735
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.716888040231604 0.250134071113908 no 2499 0.236721591045557 3721 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1813 st051246 8.6015 µM -0.717625838457307 0.249921577318932 no 2500 0.236494010760479 3643 5291959
SGTC_2839 9003951 25.97 µM -0.717982264217789 0.249818957213525 no 2501 0.236384111282784 3682 2990634
SGTC_369 0957-0393 4.5 µM -0.718243885377627 0.249743646955687 no 2502 0.236303461527211 3704 6997992
SGTC_2285 7945142 200 µM -0.719132330382984 0.249487989218018 no 2503 0.236029694384125 3734 2970608
SGTC_1837 st055472 66.5 µM -0.71964642295397 0.249340118175781 no 2504 0.235871360772613 3763 676091
SGTC_1017 4239-0030 168 µM -0.722948571290872 0.248391416410069 no 2505 0.234855740555728 3744 1149593
SGTC_3260 9137109 49.47 µM -0.723089312592543 0.24835102445884 no 2506 0.234812507441423 3576 17478346
SGTC_3208 9114115 49.47 µM -0.724334201688113 0.247993900891698 no 2507 0.234430292238889 3716 650895
SGTC_2776 terbinafine 19.92 µM -0.726605868998135 0.247342930504521 no 2508 0.233733715951034 3727 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_424 splitomicin 100 mM -0.728823118432376 0.246708436067127 no 2509 0.233054934035394 3767 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.73030840574165 0.246283889979858 no 2510 0.232600845663895 3728 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_274 sirtinol 40.1 µM -0.730536001590851 0.246218869899387 no 2511 0.232531307575785 3755 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_396 dithiazanine 1.25 µM -0.73366906414559 0.245324745933373 no 2512 0.231575228643451 3717 10578 An antihelmenthic.
SGTC_725 1497-0963 19 µM -0.734042548085016 0.245218276373917 no 2513 0.231461403402795 3761 3549977
SGTC_2764 methyldopa 94.69 µM -0.735661829581664 0.244756953164377 no 2514 0.230968262294861 3737 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2282 7944268 200 µM -0.736825715752512 0.244425658066494 no 2515 0.230614171335778 3747 2970414
SGTC_105 0111-0055 734.78 µM -0.739711705010439 0.2436052173303 no 2516 0.229737472104518 3762 5179370
SGTC_808 0711-0032 135 µM -0.740386192025365 0.243413686052117 no 2517 0.229532847386187 3696 4252555
SGTC_1129 3453-1384 223 µM -0.740826882372765 0.243288589004661 no 2518 0.229399206678841 3864 1084452
SGTC_3236 9132701 49.47 µM -0.741175230656819 0.24318972933312 no 2519 0.229293599856237 3756 24282524
SGTC_1438 4092-1045 4 µM -0.742915915713519 0.24269605633933 no 2520 0.228766294597629 3732 1351342
SGTC_365 0121-0052 13.6 µM -0.743869269535458 0.242425907247649 no 2521 0.228477784154611 3766 3101739
SGTC_3132 9126706 49.47 µM -0.744515978419066 0.242242744015667 no 2522 0.228282189119695 3755 850858
SGTC_2299 7976368 114.88 µM -0.745476879641208 0.241970732673037 no 2523 0.227991741506383 3779 2979718
SGTC_330 1488-0319 80.1 µM -0.745833727528023 0.241869758590461 no 2524 0.2278839315351 3787 6846614
SGTC_941 3237-0776 460 µM -0.74588495793938 0.241855264252065 no 2525 0.227868456289105 3749 760008
SGTC_735 3076-0345 636 µM -0.74687599849389 0.241574967362959 no 2526 0.227569207590418 3783 2888990
SGTC_56 0957-0365 83.25 µM -0.748135810419256 0.241218908408337 no 2527 0.22718912194035 3703 6752360
SGTC_1972 st070201 17.4 µM -0.749503312717946 0.240832736140403 no 2528 0.226776951365658 3717 2829099
SGTC_2237 6667747 47.222 µM -0.749717223740066 0.240772359728984 no 2529 0.226712515923041 3715 729940 YDL015C TSC13
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.750147091250977 0.240651054483801 no 2530 0.226583060138586 3827 5282309
SGTC_3027 9089541 49.47 µM -0.750610742996202 0.240520252893019 no 2531 0.226443476926674 3737 9943819
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.750650881508911 0.240508931169252 no 2532 0.226431395437647 3722 390807
SGTC_212 3807-4682 38.772 µM -0.751460534287878 0.240280617344121 no 2533 0.226187771790567 3857 3125501 YBL034C STU1
SGTC_3124 9127567 49.47 µM -0.752072328600778 0.240108175950217 no 2534 0.226003781826634 3702 17592030
SGTC_2827 7993847 71.43 µM -0.752393123885124 0.2400177830095 no 2535 0.225907340230479 3778 2985692
SGTC_1313 1220-0047 237 µM -0.753442258365282 0.239722289975441 no 2536 0.225592098506977 3760 3528706
SGTC_1404 3909-7820 48.3 µM -0.754158484611449 0.239520675988307 no 2537 0.225377031409473 3722 23741373
SGTC_2504 purpurogallin 52.29 µM -0.756791487933681 0.238780295526446 no 2538 0.224587396628011 3705 5281571 An antioxidant.
SGTC_2861 9024595 19.48 µM -0.75731745378212 0.238632548107196 no 2539 0.224429848338765 3676 16482810
SGTC_1399 3562-5772 25 µM -0.759490649983486 0.238022613117529 no 2540 0.223779552564338 3716 23847490
SGTC_1610 st001799 48.1 µM -0.759752487085524 0.237949182949833 no 2541 0.223701274175182 3698 621897
SGTC_919 tnp00227 403.569 nM -0.760331253495168 0.237786916511855 no 2542 0.223528302371416 3767 1269246 A methoxyflavone. YNL221C POP1
SGTC_3021 9087658 49.47 µM -0.760524485560692 0.237732754323043 no 2543 0.223470569421146 3725 25237042
SGTC_2156 5649887 115 µM -0.761286662301154 0.237519185182702 no 2544 0.223242932642615 3818 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_3013 9080133 71.4286 µM -0.761627186184308 0.237423801211313 no 2545 0.223141272185799 3820 17050193
SGTC_606 k015-0008 38.6 µM -0.76288103793206 0.237072766780419 no 2546 0.222767172887968 3811 1970475
SGTC_3073 9114972 49.47 µM -0.764328243969603 0.236667954756835 no 2547 0.222335829061836 3704 41905075
SGTC_1489 4065-0444 182 µM -0.764415899611484 0.236643447966874 no 2548 0.22230971836392 3730 2877968
SGTC_493 zm226600 134 µM -0.765582143535614 0.236317522035522 no 2549 0.221962486332758 3781 5240098 A potassium channel opener. YCR052W RSC6
SGTC_205 1486-1330 71.903 µM -0.766527883527242 0.236053401119372 no 2550 0.221681133647364 3761 4118834
SGTC_3150 9097574 49.47 µM -0.766566657952094 0.236042575889279 no 2551 0.221669602809687 3754 17217476
SGTC_173 1273-0061 2.693 µM -0.768471596525923 0.235511082952207 no 2552 0.221103529472021 3778 2847414 YPL266W DIM1
SGTC_2186 6124449 200 µM -0.771027678790096 0.234798954420224 no 2553 0.220345262823193 3755 3834182 YLR033W RSC58
SGTC_542 3381-0244 89.3 µM -0.771100558573284 0.234778667466303 no 2554 0.220323664778067 3801 1112843
SGTC_1490 4089-0339 670 nM -0.772360519838956 0.234428095495722 no 2555 0.219950465070491 3739 742542
SGTC_2079 5212404 121 µM -0.77275098378106 0.234319511519496 no 2556 0.219834883571897 3744 758462
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.772767886500105 0.234314811677153 no 2557 0.219829880973816 3775 77254
SGTC_561 1550-0330 72.9 µM -0.773023278655275 0.234243805614403 no 2558 0.21975430201649 3740 6812934
SGTC_1834 st055981 52.8 µM -0.773282440508247 0.234171763650041 no 2559 0.219677622732922 3843 471719 YDL150W RPC53
SGTC_1070 indatraline 8.81 µM -0.773303355369272 0.234165950259681 no 2560 0.219671435236968 3788 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.77488122732085 0.233727603339843 no 2561 0.21920492295887 3814 23847180
SGTC_842 0271-0008 11.1 µM -0.77553394094444 0.233546406749758 no 2562 0.219012108853805 3857 1221709
SGTC_692 k241-0027 77.8 µM -0.782502327997758 0.231616810491754 no 2563 0.216959708875043 3828 3600480
SGTC_1480 1070-0044 41.2 µM -0.782562981525403 0.231600054194151 no 2564 0.216941893522526 3803 3124987
SGTC_1885 st057546 99.9 µM -0.782926649755119 0.231499600457021 no 2565 0.216835093436006 3871 702008
SGTC_117 lucigenin 22.078 µM -0.783398332485776 0.231369346760845 no 2566 0.216696617536704 3827 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2834 9001755 58.44 µM -0.783809038280978 0.231255964948529 no 2567 0.216576084819563 3759 2989575
SGTC_2437 5741531 144.16 µM -0.785298426702151 0.230845055905926 no 2568 0.216139309023581 3840 2262990
SGTC_3064 1327-0027 10 µM -0.786451588295428 0.230527189116939 no 2569 0.215801485262481 3685 16000455 YPR107C YTH1
SGTC_336 4111-0029 111 µM -0.787355385009697 0.2302782303716 no 2570 0.215536928093783 3792 3131175
SGTC_2126 5251174 33.877 µM -0.788320890932235 0.230012439475309 no 2571 0.215254515465521 3816 790722
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.789029231696284 0.22981755194579 no 2572 0.215047460857409 3802 6312947
SGTC_2311 7694451 200 µM -0.791135908808712 0.229238483436249 no 2573 0.214432343348906 3787 2163142
SGTC_259 usnic acid 108.925 µM -0.791910554664891 0.22902576016787 no 2574 0.214206416129493 3878 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1143 3454-2408 5.08 µM -0.792074330417451 0.228980800366208 no 2575 0.21415866830137 3758 X1143
SGTC_2932 9016711 44.54 µM -0.792485840117444 0.228867854374154 no 2576 0.214038722475528 3822 7117328
SGTC_1039 k821-0043 94 µM -0.793030819105672 0.228718323551926 no 2577 0.213879933548423 3780 15992768
SGTC_1703 st026983 48.3 µM -0.793920214320769 0.22847440997647 no 2578 0.213620940439489 3804 1104023
SGTC_3354 9151612 71.43 µM -0.79796293315498 0.227367551994054 no 2579 0.212446000339906 3865 27261949
SGTC_1113 artemisinin 1.17947 µM -0.79836089308076 0.227258757917612 no 2580 0.21233054525768 3831 2240 An anti-malaria and mitochondrial poison.
SGTC_1765 st044815 90.4 µM -0.798864878705821 0.227121020701543 no 2581 0.212184382915287 3875 645695
SGTC_1982 st072467 71.9 µM -0.800529845934893 0.226666326640723 no 2582 0.211701939225199 3817 3163533
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.801907057342842 0.22629060577894 no 2583 0.211303361728737 3847 5106787 A p450 inhibitor.
SGTC_473 2-arachidonoylglycerol 10 µM -0.803754646896255 0.225787112776679 no 2584 0.210769343565421 3717 5282280 An endocannabinoid.
SGTC_687 k029-0044 34.9 µM -0.804070611702063 0.225701071608513 no 2585 0.210678097986519 3873 5829338
SGTC_328 k915-0120 63.5 µM -0.806002567229193 0.225175379595217 no 2586 0.210120684420769 3837 6624543
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.807720366790728 0.224708543293174 no 2587 0.209625788174798 3821 2724278 An inhibitor of dopamine biosynthesis.
SGTC_898 1000-0849 28.3 µM -0.807848446311239 0.224673757876543 no 2588 0.20958891608216 3811 6751807
SGTC_899 1083-0020 478 µM -0.808338597527258 0.224540664773935 no 2589 0.20944784444295 3915 767123
SGTC_1989 st071868 50.2 µM -0.809349033682658 0.224266437422342 no 2590 0.209157204658371 3844 16414057
SGTC_393 acivicin 6.25 µM -0.810054817321143 0.22407500409833 no 2591 0.208954335428219 3712 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2581 avocatin a 64 µM -0.81059825293296 0.223927668534932 no 2592 0.2087982102444 3863 6710728 A skin care supplement.
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.8126135245625 0.223381771536265 no 2593 0.20821983745869 3831 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.81289259104034 0.223306237713261 no 2594 0.208139821369887 3864 61125 An anti-inflammatory.
SGTC_1296 1068-0102 11.9 µM -0.813741417754332 0.223076578501414 no 2595 0.207896550809478 3871 767053
SGTC_862 0452-0056 10.2 µM -0.813920349265129 0.223028183823301 no 2596 0.207845291142497 3803 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2616 abietic acid 100 µM -0.815481497002711 0.222606202026377 no 2597 0.207398375796323 3852 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.817046489101508 0.222183638316082 no 2598 0.206950930613453 3871 1273210
SGTC_258 haloperidol 50.781 µM -0.817996643860195 0.221927310402918 no 2599 0.206679551828967 3889 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_683 panaxydol 45 µM -0.818910493989726 0.221680935960237 no 2600 0.206418741112747 3827 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2589 lobaric acid 100 µM -0.819121337122273 0.221624114744983 no 2601 0.206358594667619 3885 73157 A novel microtubule depolymerizer.
SGTC_1908 st060353 56.5 µM -0.820557367050037 0.221237333012216 no 2602 0.205949220019243 3895 4227716
SGTC_568 1193-0097 7.48 µM -0.822444388227048 0.220729668383322 no 2603 0.205412012565105 3738 3646150
SGTC_780 0109-0199 192 µM -0.823948034815676 0.220325620949257 no 2604 0.204984542641813 3934 610414
SGTC_395 anisomycin 6.25 µM -0.82461795766213 0.220145741468312 no 2605 0.204794261478913 3875 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_307 1501-1223 22.3 µM -0.825370761714346 0.219943708282009 no 2606 0.204580564594362 3870 2830329
SGTC_492 tmb-8 126 µM -0.826443758823271 0.219655927517158 no 2607 0.204276204628694 3803 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_708 3448-5400 146 µM -0.8270498348456 0.219493471871017 no 2608 0.204104407936336 3831 3462195
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.827127047038317 0.21947278048677 no 2609 0.204082527756353 3961 688801
SGTC_426 0988-0037 14.6 µM -0.82809685158224 0.219212986944853 no 2610 0.203807826206461 3837 5383008
SGTC_25 0118-0223 35.662 µM -0.830560037835167 0.218553938043947 no 2611 0.20311110902086 3879 5333628
SGTC_1570 verbenone 133 µM -0.830968135168074 0.218444857989721 no 2612 0.202995815332133 3900 29025 A natural terpanoid with antifungal properties.
SGTC_2919 7978188 46.38 µM -0.832253079339317 0.218101610999988 no 2613 0.202633054448509 3834 2980291
SGTC_2325 6158266 200 µM -0.83446850843893 0.217510534339393 no 2614 0.202008513007498 3929 3623240
SGTC_778 3456-2434 196 µM -0.837068366521424 0.216818072636904 no 2615 0.201277070164862 3906 5539063
SGTC_594 1487-1584 10.8 µM -0.842020163679207 0.215502713179385 no 2616 0.199888333511248 3851 5013332
SGTC_1290 0986-0249 10.2 µM -0.843188742125615 0.215192976840695 no 2617 0.199561446818898 3810 53329
SGTC_281 1672-3440 14.9 µM -0.843208937131845 0.215187626346769 no 2618 0.199555800495074 3930 6833000
SGTC_391 gliotoxin 8.33 µM -0.843469871374059 0.215118500999055 no 2619 0.199482854511177 3986 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_306 1672-3436 11.6 µM -0.844039562871766 0.214967626083092 no 2620 0.199323649072753 3909 6797378
SGTC_1044 1222-0021 1.78 µM -0.84416821183345 0.21493356369208 no 2621 0.199287707550059 3888 4306703
SGTC_2506 ethyl hematommate 54.16 µM -0.845228670573454 0.214652905429797 no 2622 0.198991588789442 3979 3940691 An allergen.
SGTC_1930 st074634 34.3 µM -0.845341135930273 0.21462315313717 no 2623 0.198960199917993 3824 684253 YOR116C RPO31
SGTC_2965 9082772 38.63 µM -0.847447468708036 0.214066373592075 no 2624 0.198372877783013 3888 16459634
SGTC_250 brefeldin a 552.239 µM -0.848674054713727 0.213742530448955 no 2625 0.198031343553945 3773 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.851650701746618 0.212957823851198 no 2626 0.197203994962822 3841 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1667 st014849 34.6 µM -0.851929494105038 0.212884414534894 no 2627 0.197126612857991 3936 5348460
SGTC_2783 7738165 71.43 µM -0.853146564068056 0.212564118672482 no 2628 0.196789015990523 3903 17201110
SGTC_3278 9139605 49.47 µM -0.853595740654319 0.212445980178075 no 2629 0.196664509680071 3945 7958859
SGTC_2619 obliquin 87.91 µM -0.85367317720909 0.212425617370518 no 2630 0.196643050027983 3868 6708593 A bioactive alkalod. YER133W GLC7
SGTC_185 k048-0037 25.491 µM -0.854011500548394 0.212336664842991 no 2631 0.19654930860626 3940 6827589
SGTC_1281 0884-0031 11.8 µM -0.854178686835066 0.212292715987496 no 2632 0.196502995224987 3912 1548255
SGTC_1860 st056228 74.6 µM -0.855680349370339 0.21189820699217 no 2633 0.196087306247144 3894 688679
SGTC_3226 9131256 49.47 µM -0.856420568875358 0.211703898274577 no 2634 0.195882595695741 3807 17178073
SGTC_2102 5377816 72.7585 µM -0.857102653383624 0.21152494243205 no 2635 0.195694077450286 3953 1379702
SGTC_1556 plumbagin 1.48 µM -0.857402215475189 0.211446375498797 no 2636 0.195611317660642 3815 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1088 bifonazole 369 nM -0.858154136445451 0.211249242519127 no 2637 0.195403678662352 3860 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1611 st001856 99.4 µM -0.858989017554866 0.211030485879846 no 2638 0.195173287582184 3900 647478
SGTC_852 0418-0143 439 µM -0.86115036501295 0.210464784024533 no 2639 0.194577616518243 3954 5369229
SGTC_73 0327-0325 16.231 µM -0.861384342708574 0.210403597142326 no 2640 0.194513198296993 3846 53298
SGTC_718 1130-0073 349 µM -0.863441044050779 0.209866204163347 no 2641 0.193947510526962 3981 6740020
SGTC_2183 6420625 130.508 µM -0.863474349166115 0.209857508553738 no 2642 0.193938358339947 3896 2897619
SGTC_2657 nystatin 74.44 µM -0.863908991062341 0.209744047618152 no 2643 0.193818943643492 3956 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1375 2910-0797 186 µM -0.865100642944375 0.20943315834452 no 2644 0.193491775930811 3943 742508
SGTC_501 nsc-95397 161 µM -0.86611670380137 0.209168293172378 no 2645 0.193213082937583 3969 262093
SGTC_199 4063-0024 41.6 µM -0.866905236358237 0.208962875705741 no 2646 0.192996967105221 3933 306215
SGTC_1764 st044502 93.5 µM -0.86748358710114 0.208812287430987 no 2647 0.192838550406391 3985 8407
SGTC_1421 4029-0249 71.4 µM -0.867690702028893 0.208758375363813 no 2648 0.192781838647029 3990 2894095
SGTC_2531 methyl deoxycholate 70.07 µM -0.867869604415273 0.208711813631668 no 2649 0.192732860187554 3894 16667744 Haematoxylin.
SGTC_2973 9094665 17.96 µM -0.868216377003941 0.20862157887269 no 2650 0.192637945225948 4000 25237061 YIL048W NEO1
SGTC_2430 5571206 200 µM -0.870448955199357 0.208041183737435 no 2651 0.192027551554542 3953 1731771
SGTC_2523 spermine 47.74 µM -0.873103377260294 0.207352365180811 no 2652 0.19130336662681 3938 1103 A DNA binding polyamine.
SGTC_497 capsazepine 133 µM -0.875694478724159 0.206681280519572 no 2653 0.190598073853278 3923 2733484 A calcium channel blocker.
SGTC_2223 6903751 107.57 µM -0.87598610057706 0.206605832258601 no 2654 0.190518795010112 3892 5598863
SGTC_2397 5161689 200 µM -0.876329093762232 0.206517114110613 no 2655 0.190425576530905 3966 2259942
SGTC_3215 9129942 49.47 µM -0.877434708791969 0.206231290896465 no 2656 0.190125283860312 3912 17682944
SGTC_2340 7987427 183.45 µM -0.87785537372196 0.206122602356678 no 2657 0.190011104827255 3966 2239331
SGTC_814 3342-0569 96 µM -0.879157099073682 0.205786486651265 no 2658 0.189658050938683 3976 4346283
SGTC_1622 st003707 19.4 µM -0.881199289333717 0.205259832923407 no 2659 0.189104981938167 3977 10140899
SGTC_1190 1486-1332 13 µM -0.882781631174495 0.204852319112568 no 2660 0.18867713347964 3935 4150046
SGTC_3016 9080866 49.47 µM -0.883203662816362 0.204743711077496 no 2661 0.188563121474649 3939 17066299
SGTC_1814 st052110 31.539 µM -0.883744069019979 0.204604689873933 no 2662 0.188417192575065 3876 674163
SGTC_2557 derrustone 83.84 µM -0.88437080404623 0.204443530667035 no 2663 0.188248039084094 3930 629853 An antioxidant.
SGTC_1260 0700-1617 7.75 µM -0.884421719746689 0.204430441477332 no 2664 0.188234301239197 3985 2853078
SGTC_1700 st030840 7.9285 µM -0.885756611387229 0.20408745126682 no 2665 0.187874347531081 3985 5499307
SGTC_1988 st071872 53.4 µM -0.885793545923452 0.204077966096036 no 2666 0.187864394175127 3968 16414116
SGTC_14 0354-0009 295 µM -0.887699554089035 0.203588840022392 no 2667 0.187351192918767 4018 1713507
SGTC_2398 5228213 48.84 µM -0.887922181193431 0.20353175435897 no 2668 0.187291306149988 3957 80771 YMR134W ERG29
SGTC_785 1270-0111 65.3 µM -0.88868949401696 0.203335074481871 no 2669 0.187084989442609 3895 6741994
SGTC_934 2950-0684 338 µM -0.889442555687156 0.20314215781616 no 2670 0.186882641361682 4024 1121253
SGTC_609 0986-0026 86.3 µM -0.889540947598638 0.203116960198778 no 2671 0.1868562134086 3915 2848610
SGTC_2860 9025725 38.96 µM -0.892106244321686 0.202460660821924 no 2672 0.186167994132066 3957 40546248
SGTC_534 k292-0788 63.4 µM -0.892533092355178 0.202351580211283 no 2673 0.186053631735173 3952 4146317
SGTC_41 0478-0632 82.643 µM -0.89369169451271 0.202055677755802 no 2674 0.185743435193285 3868 3750424
SGTC_1369 1866-0067 208 µM -0.897568467875616 0.201067449572653 no 2675 0.18470782799274 3934 3531355
SGTC_2532 xanthone 78.9 µM -0.897900658920055 0.200982905822536 no 2676 0.184619256679113 3966 7020 An insecticide.
SGTC_1120 ficusin 1.78878 µM -0.899489425933796 0.20057885420847 no 2677 0.184196012787734 4049 6199 A DNA cross-linker.
SGTC_1237 0330-0133 46.1 µM -0.902116457669458 0.199911824466443 no 2678 0.183497503613516 3898 X1237 YHR072W ERG7
SGTC_133 0724-0033 378.92 µM -0.902731630705482 0.199755818829299 no 2679 0.183334172342859 3809 280309
SGTC_227 fluconazole 33.516 µM -0.902883530686681 0.199717308825843 no 2680 0.18329385615837 3975 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_3044 9093193 49.47 µM -0.90380655715098 0.199483397258497 no 2681 0.183048992090337 4002 25236277
SGTC_1378 2093-0007 380 nM -0.905059347838726 0.19916618142111 no 2682 0.182716973532595 4047 3618014
SGTC_2949 9072542 2.23 µM -0.905977268196044 0.198933950214109 no 2683 0.182473942197139 4057 16457352
SGTC_1134 3477-0009 42.5 µM -0.907489415896107 0.198551737252442 no 2684 0.182074022003916 4087 3973534
SGTC_490 phenamil 164 µM -0.909500966930666 0.198043981384394 no 2685 0.181542873822476 3957 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1684 st024538 14.6195 µM -0.909897516425505 0.197943976936123 no 2686 0.181438279845012 3966 6732859
SGTC_784 4579-0127 173 µM -0.910808429159099 0.197714372533945 no 2687 0.181198160206214 4058 1948547
SGTC_64 000l-0018 272.079 µM -0.912185946490938 0.197367461797344 no 2688 0.180835420318457 3925 6811119
SGTC_2327 6189656 200 µM -0.912243672235469 0.197352932322329 no 2689 0.18082022941502 4075 5349088
SGTC_2318 6029776 164 µM -0.913428716820784 0.197054801524038 no 2690 0.180508554041824 3998 818325
SGTC_1284 0929-0043 16 µM -0.914549447194892 0.196773101679114 no 2691 0.180214104012595 3952 1239883
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.915976753724713 0.196414696029012 no 2692 0.179839543795606 3997 165521
SGTC_2867 9039098 71.43 µM -0.916730736411231 0.196225526043291 no 2693 0.17964187778812 3958 6463460
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.916942425891961 0.196172434219773 no 2694 0.179586405294047 4043 94937 An inhibitor of serotonin biosynthesis.
SGTC_1762 st045503 25.4615 µM -0.917823878841166 0.195951459062582 no 2695 0.179355539361806 4076 4645554
SGTC_1482 3346-2049 8.48 µM -0.918371756316502 0.19581418548374 no 2696 0.179212136004466 3985 3826804
SGTC_2870 9038528 12.99 µM -0.919494208390477 0.19553313154743 no 2697 0.17891856678042 4053 6463316
SGTC_1450 4112-4260 37.6 µM -0.919721795507796 0.195476175252833 no 2698 0.178859079939552 3967 1633175
SGTC_2543 pimpinellin 60.67 µM -0.919891130825631 0.195433803679646 no 2699 0.178814827062826 3830 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2691 st077356 60.2 µM -0.919959587411648 0.195416675858228 no 2700 0.1787969390664 4061 2839272
SGTC_7 0192-1582 4.227 µM -0.920983997899316 0.195160477524732 no 2701 0.178529390825011 4030 252616
SGTC_629 3448-6466 76.7 µM -0.921068834164185 0.195139269688981 no 2702 0.178507245204876 3990 573744
SGTC_1855 st056195 39.6 µM -0.921668175693136 0.194989482906269 no 2703 0.17835084265924 3957 4028379
SGTC_2789 5281112 71.43 µM -0.921693067722134 0.194983263429769 no 2704 0.178344348770673 4027 765948
SGTC_2380 9035439 200 µM -0.922199620021918 0.194856723408898 no 2705 0.178212230632262 4113 6462575
SGTC_2884 9058502 51.95 µM -0.923116662100515 0.194627767491592 no 2706 0.177973206194347 4030 6471554
SGTC_2525 harmine 47.85 µM -0.923246612528972 0.194595336295424 no 2707 0.177939351341339 3988 5280953 A monoamine oxidase inhibitor
SGTC_2650 prasterone 100 µM -0.924623244645324 0.194251977833121 no 2708 0.177580958796735 3971 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_75 0159-0059 199.013 µM -0.925129144468972 0.194125889473931 no 2709 0.17744936733316 4073 5377270
SGTC_1752 st044819 83.042 µM -0.928179256545114 0.193366749191616 no 2710 0.176657296341635 4014 441209 YML126C ERG13
SGTC_734 2023-0417 80 µM -0.929095658522985 0.193139020883576 no 2711 0.176419757107285 4022 3935732
SGTC_2906 7926292 26.41 µM -0.930875034225968 0.192697309174159 no 2712 0.175959105083054 4030 2966319
SGTC_1835 st008666 49.2 µM -0.931348220487557 0.192579949540328 no 2713 0.175836733016091 3960 690455
SGTC_2995 9067767 71.4286 µM -0.931729415579947 0.192485437332779 no 2714 0.175738190264646 4047 11673567
SGTC_1318 1280-3875 124 µM -0.932107952794376 0.192391612176521 no 2715 0.175640369229432 4027 373245
SGTC_415 dibenzyl ketone 100 µM -0.932783141662084 0.192224327660224 no 2716 0.175465973579034 4013 7593
SGTC_3135 9127742 49.47 µM -0.933823852303421 0.191966655946741 no 2717 0.175197381761563 4092 3643468
SGTC_107 0358-0022 2.6945 µM -0.936331519245029 0.19134664642447 no 2718 0.174551262314546 4038 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2278 7948257 134.34 µM -0.937238346418309 0.191122739919068 no 2719 0.174317984439041 4023 1247028
SGTC_2320 7373003 200 µM -0.938205737784568 0.190884056577248 no 2720 0.174069345131141 4114 5415828
SGTC_206 4546-0025 72.014 µM -0.941015100076754 0.190191943205232 no 2721 0.173348560522515 4074 6620745 YIL048W NEO1
SGTC_1739 st037196 92.5 µM -0.94119345457003 0.190148055975977 no 2722 0.173302865199972 4099 612214
SGTC_914 3820-6779 408 µM -0.941303671785039 0.19012093822191 no 2723 0.173274630826913 3970 2893481
SGTC_442 cape 100 µM -0.941504212856901 0.190071603355786 no 2724 0.173223265680955 3977 5281787
SGTC_2518 prenyletin 46.28 µM -0.942059623707451 0.189935008480627 no 2725 0.173081057366517 3973 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_247 mechlorethamine 29.705 µM -0.942866989181409 0.189736556838604 no 2726 0.172874470834213 3909 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_251 melphalan 456.522 µM -0.944609303648689 0.189308728088229 no 2727 0.172429187729428 4058 460612 A DNA alkylator.
SGTC_1742 st038235 28.8875 µM -0.946660355061946 0.188805850078135 no 2728 0.171905939143849 4079 564103 YBR002C RER2
SGTC_699 0375-0592 111 µM -0.948306076854682 0.18840294688865 no 2729 0.171486829074933 4108 762578
SGTC_916 4466-0038 42 nM -0.949422467344984 0.188129935931991 no 2730 0.171202893960534 4098 5722064 YGL116W CDC20
SGTC_1848 st056003 16.4 µM -0.950082335895427 0.187968681327759 no 2731 0.171035208946679 4061 146492
SGTC_3160 9100216 49.47 µM -0.955125448812742 0.186739096540698 no 2732 0.169757130400112 3949 17191039
SGTC_2167 5876490 200 µM -0.955473616295267 0.186654392338501 no 2733 0.169669120746946 4187 686534
SGTC_2977 9011197 71.43 µM -0.956265082492291 0.18646192837471 no 2734 0.169469163109987 4133 2704722
SGTC_440 fluspirilene 35.1 µM -0.95660932819859 0.186378255157566 no 2735 0.169382239379995 4134 3396 An atypical antipsychotic.
SGTC_265 mycophenolic acid 32.932 µM -0.957470173284886 0.18616911784274 no 2736 0.169164997043779 4130 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_858 0438-0351 2.77 µM -0.95852201298478 0.185913777010483 no 2737 0.16889979838234 4011 2799119
SGTC_2401 5128683 200 µM -0.961009257432983 0.185310846935253 no 2738 0.168273756584508 4027 708373
SGTC_2679 rapamycin 1 nM -0.963900093552563 0.18461161015038 no 2739 0.167548008477957 3990 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_864 0469-0573 172 µM -0.963905259618228 0.184610362050431 no 2740 0.167546713338099 4023 689425
SGTC_2220 6782180 200 µM -0.964519772642643 0.184461935698152 no 2741 0.167392700078272 3963 833803
SGTC_2158 5657123 3.6195 µM -0.964660672228011 0.184427913992486 no 2742 0.167357399766559 3972 2858827
SGTC_1927 st060202 13.8 µM -0.965721616658415 0.184171863029483 no 2743 0.167091749872676 3928 688887
SGTC_762 1165-0429 115 µM -0.96647027027781 0.183991314326759 no 2744 0.166904458190684 4058 5967793
SGTC_452 diindolylmethane 8 µM -0.966965100278194 0.183872039395069 no 2745 0.166780740263371 4053 3071 Inhibits expression of several cancer promoting factors.
SGTC_1702 st027038 51 µM -0.968728135191672 0.183447465084313 no 2746 0.166340425471792 4069 5521182
SGTC_138 0850-0259 40.9225 µM -0.968809393100415 0.183427911287497 no 2747 0.166320149568268 4026 6813004
SGTC_1132 3456-3614 2.5 µM -0.969193312960219 0.183335542887583 no 2748 0.166224373438392 4137 3125502
SGTC_2161 5662504 8.5105 µM -0.969408399515875 0.183283807262967 no 2749 0.166170731568207 4028 2859334
SGTC_2381 9035592 200 µM -0.97003411291835 0.18313335370227 no 2750 0.166014744321632 4053 4749657
SGTC_1176 0848-0131 83.3 µM -0.97065555145312 0.182984004314624 no 2751 0.165859916460405 4088 6769040
SGTC_3262 9137218 49.47 µM -0.972599055644193 0.182517415579033 no 2752 0.165376306093121 3919 17650664
SGTC_1008 4106-0037 6 µM -0.973117880682123 0.1823929839102 no 2753 0.165247359104475 3999 2905394
SGTC_710 3448-4187 58 µM -0.97340467643129 0.18232422340901 no 2754 0.165176107809401 4037 3946412
SGTC_2820 7989630 71.43 µM -0.97399482620929 0.182182783454258 no 2755 0.165029554063282 4036 2984098
SGTC_3315 9136395 68.55 µM -0.97704123193955 0.181453749048069 no 2756 0.164274370038368 4058 16876844
SGTC_3133 9127736 49.47 µM -0.977121184061184 0.181434640357399 no 2757 0.164254580655023 4037 27243420
SGTC_598 3937-0236 20.2 µM -0.98293975476916 0.180047375349145 no 2758 0.162818545144227 4140 1379313
SGTC_2174 5790901 200 µM -0.987648322557684 0.178929646365392 no 2759 0.161662455803732 4096 786020
SGTC_3237 9133362 49.47 µM -0.988396887989333 0.178752353592851 no 2760 0.161479155511515 4041 43845137
SGTC_38 0929-0051 58.268 µM -0.988480545712806 0.178732546687099 no 2761 0.161458678770195 4079 1379719
SGTC_2219 9098279 200 µM -0.988917118728898 0.178629205543444 no 2762 0.161351847100664 4014 902349
SGTC_1654 st012436 41.8 µM -0.991021105493395 0.178131698876181 no 2763 0.160837637315337 4015 4323132
SGTC_2840 9008771 71.43 µM -0.991343635258389 0.178055511085344 no 2764 0.160758906420142 4022 2992978
SGTC_2205 7238770 200 µM -0.99190002674149 0.177924128915661 no 2765 0.160623148039671 4139 279867
SGTC_1454 4239-0054 42.6 µM -0.99311097884753 0.177638395035769 no 2766 0.160327937122888 4194 1340767
SGTC_234 nsc-17383 10.7 µM -0.994225437385687 0.177375685605283 no 2767 0.160056563334852 4089 408974
SGTC_1402 3909-7673 35.9 µM -0.995769096456037 0.177012206881738 no 2768 0.159681174424791 4088 5328014
SGTC_1339 1486-1321 22.7 µM -0.998887895593886 0.176279273890294 no 2769 0.158924500272132 4095 3469382
SGTC_1505 k297-0037 20.6 µM -0.998940201365213 0.176266998175765 no 2770 0.158911830062445 4098 4089396
SGTC_3142 9086498 49.47 µM -0.999526091319069 0.176129531812939 no 2771 0.158769953130371 4006 25236367
SGTC_625 k213-0058 121 µM -1.00273062493475 0.175378858674137 no 2772 0.157995424741158 4155 3655420
SGTC_997 3996-0078 137 µM -1.00283264888647 0.175354992573572 no 2773 0.157970806601206 4136 735687
SGTC_2324 6149169 200 µM -1.00505234946587 0.174836255721665 no 2774 0.157435821558355 3993 2888231
SGTC_602 3130-1533 38.1 µM -1.00778881456529 0.174198094620235 no 2775 0.156777928407359 4130 720941
SGTC_1427 4048-4900 550 nM -1.00882968169849 0.173955746891889 no 2776 0.156528161746793 4089 24132586
SGTC_2215 7188065 200 µM -1.00954720459283 0.173788809111769 no 2777 0.156356137460554 4113 940217
SGTC_350 k064-0020 19.8 µM -1.01280171323458 0.173032899957885 no 2778 0.155577441113208 4127 2790705
SGTC_1001 4048-4355 44.4 µM -1.01508388155314 0.172504082931334 no 2779 0.155032922153792 4076 21824233
SGTC_2146 5545642 200 µM -1.01537512866195 0.172436670284243 no 2780 0.15496352207028 4058 825326
SGTC_2358 9037157 4 µM -1.01813615831172 0.171798431641793 no 2781 0.154306626925408 4114 2388925
SGTC_2143 5623677 140.463 µM -1.01935903876126 0.171516233739024 no 2782 0.154016272447689 4064 5375313
SGTC_1036 k216-0215 33.5 µM -1.01986505726625 0.171399549116883 no 2783 0.153896231808816 4093 622330
SGTC_1468 k284-1086 134 µM -1.01990967392008 0.171389263237331 no 2784 0.15388565055909 4089 15996457
SGTC_1697 st025554 27.742 µM -1.02035276211805 0.171287135535637 no 2785 0.153780594252583 4089 1269519
SGTC_2933 9026794 32.47 µM -1.02280234878818 0.17072323093999 no 2786 0.153200653637776 4071 17586027
SGTC_1479 0549-0158 134 µM -1.02281832576508 0.170719556881045 no 2787 0.153196875845761 4152 5440202
SGTC_1309 pyrazolanthrone 13.4 µM -1.02295185077641 0.170688853504007 no 2788 0.153165305971301 4092 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_506 n9-isopropylolomoucine 153 µM -1.0242130505284 0.170399021608162 no 2789 0.152867327963534 4129 6610355
SGTC_2113 5491891 107.031 µM -1.02451768140836 0.170329062743051 no 2790 0.152795411869449 4124 789979
SGTC_2620 irigenin 100 µM -1.02591823668164 0.170007660249626 no 2791 0.15246506289305 4162 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2083 5306046 65.942 µM -1.02617263165754 0.169949322878227 no 2792 0.15240510965258 4124 539837
SGTC_2233 sulbentine 40.3845 µM -1.02701141204057 0.169757066282836 no 2793 0.152207545216349 4106 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_15 0266-0086 27.098 µM -1.02766387734219 0.169607611397916 no 2794 0.152053982645774 4172 1712902 YIL048W NEO1
SGTC_971 1315-0384 26.7 µM -1.02891123083398 0.169322125362564 no 2795 0.151760695190868 4159 6769120
SGTC_163 TUB2.036 7.546 µM -1.02975164470911 0.169129951003392 no 2796 0.151563302649262 4098 15992207 YJR013W GPI14
SGTC_458 nppb 133 µM -1.02996752388199 0.16908060932237 no 2797 0.151512625507727 4154 4549 A chloride channel blocker.
SGTC_1785 bathophenanthroline 24 µM -1.03044106747765 0.168972407841486 no 2798 0.151401501695916 4040 72812 An iron chelator.
SGTC_3152 9099253 49.47 µM -1.03150171740943 0.168730217983846 no 2799 0.15115280163242 4051 25236131
SGTC_2685 mycophenolic acid 18.85 µM -1.03158684792244 0.168710788874094 no 2800 0.151132852110296 4094 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3271 9137798 49.47 µM -1.03219913871017 0.168571089744618 no 2801 0.150989419228085 4064 6498326
SGTC_1192 1488-0095 21.4 µM -1.03408609094726 0.168141034097594 no 2802 0.150547959023563 4182 915875
SGTC_3269 9137823 49.47 µM -1.03485261177463 0.167966537993115 no 2803 0.15036887413718 4039 17682936
SGTC_3137 9097352 49.47 µM -1.03585323236752 0.167738925255322 no 2804 0.150135309393727 4154 44120435
SGTC_318 1488-0629 67.2 µM -1.0372609228333 0.167419052113766 no 2805 0.149807136081989 4166 3662576
SGTC_756 0508-1999 28.3 µM -1.03747094491678 0.167371361970444 no 2806 0.149758214917661 4136 6753853
SGTC_1664 st014217 9.02 µM -1.03813344612973 0.167220983835671 no 2807 0.149603966075206 4173 3982782
SGTC_3125 9127534 49.47 µM -1.03990815990772 0.166818578927883 no 2808 0.14919128552819 4029 1639235
SGTC_500 h-89 112 µM -1.04225304047655 0.166287851227534 no 2809 0.148647188915794 4160 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1515 3460-0031 42.1 µM -1.04471361833979 0.165732111048946 no 2810 0.148077674403585 4080 2876596
SGTC_1419 3993-2473 62.6 µM -1.04495367495207 0.165677956807201 no 2811 0.148022190243702 4203 704026
SGTC_3282 9108498 15.4605 µM -1.04529451353396 0.165601086873451 no 2812 0.147943436305974 4117 16459645
SGTC_1012 4112-3522 18 µM -1.04545049615905 0.165565915528064 no 2813 0.147907404420524 4166 3112398
SGTC_728 3030-5151 22.5 µM -1.04881374064234 0.164808738168865 no 2814 0.147131926056646 4195 3125388
SGTC_2803 7707263 71.43 µM -1.04966188834673 0.164618146819845 no 2815 0.146936796003697 4108 2199229
SGTC_2346 9031566 143.75 µM -1.0496964876753 0.164610374871501 no 2816 0.14692883955669 4120 4771086
SGTC_104 0074-0074 590.992 µM -1.05535176472891 0.163343241997996 no 2817 0.145632237301087 3931 3943124
SGTC_1007 4101-0031 70 µM -1.05604420080126 0.163188529944251 no 2818 0.145474010686784 4130 1146276
SGTC_481 bay k-8644 50 µM -1.05626504054567 0.163139207416053 no 2819 0.145423571546043 4112 2303 A calcium channel antagonist.
SGTC_1299 1079-1439 3.74 µM -1.05976739468266 0.162358284178088 no 2820 0.144625216832878 4115 323161
SGTC_2369 9071472 200 µM -1.062108306951 0.161837687647673 no 2821 0.144093259691668 4216 17296037
SGTC_2469 5655019 90.81 µM -1.06550507743757 0.161084214695633 no 2822 0.143323714566896 4205 2788239
SGTC_2140 5586273 200 µM -1.0668497892969 0.160786563690944 no 2823 0.143019835639939 4124 854421
SGTC_26 0302-0163 425.158 µM -1.06754970372048 0.160631780328985 no 2824 0.14286184087555 4219 3100915
SGTC_1878 temozolomide 1 mM -1.06815730351195 0.160497490928836 no 2825 0.142724780387928 4077 5394 DNA alkylating agent.
SGTC_2570 licareol 100 µM -1.06954078160381 0.16019199356197 no 2826 0.142413031410621 4164 443158
SGTC_2751 anetholtrithion 17.25 µM -1.07005699705857 0.160078101153535 no 2827 0.142296826992788 4166 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_550 4123-0385 25.7 µM -1.07328013921953 0.159368178216543 no 2828 0.141572721738832 4186 5731123
SGTC_740 k014-0057 261 µM -1.07343555726908 0.159333998320689 no 2829 0.141537869007366 4159 4012779
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.07534015670639 0.158915524297155 no 2830 0.141111231871593 4163 688662
SGTC_2854 9024559 71.43 µM -1.07681903872714 0.158591085107542 no 2831 0.14078055902068 4218 3163529
SGTC_1278 0874-0585 172 µM -1.0776215140861 0.158415218869722 no 2832 0.14060134856266 4237 766306
SGTC_1686 st019653 115.5 µM -1.07855203459162 0.158211451180246 no 2833 0.140393736752417 4158 97252
SGTC_180 1486-1293 102.781 µM -1.07930819211438 0.158045992664896 no 2834 0.140225181080245 4063 4140536
SGTC_2406 ethylparaben 405.7 µM -1.07940875839548 0.158023995827887 no 2835 0.140202774131303 4173 8434 A possible steroid mimic.
SGTC_2190 6049624 200 µM -1.07977033793606 0.157944924232072 no 2836 0.140122231492555 4051 2265554
SGTC_161 4065-0411 162.148 µM -1.0802038197494 0.157850163019473 no 2837 0.140025713903171 4174 1906281 YLR208W SEC13
SGTC_1398 3558-0053 112 µM -1.08071556927545 0.157738340174703 no 2838 0.1399118276477 4091 4532369
SGTC_3336 9143619 71.43 µM -1.08302546488927 0.157234250478384 no 2839 0.139398560117554 4206 45595730
SGTC_2502 avocadyne acetate 18.59 µM -1.0839314104837 0.157036835003307 no 2840 0.13919760572809 4107 3952079
SGTC_1832 st054113 55 µM -1.08427919461366 0.156961092355495 no 2841 0.139120513591526 4182 1251267
SGTC_1721 st082152 9.2685 µM -1.08592819918127 0.156602288793579 no 2842 0.138755379900657 4114 5296051
SGTC_1944 st076371 56.9 µM -1.08622905933933 0.156536883531745 no 2843 0.138688831890886 4141 24208455
SGTC_2476 5806916 10.51 µM -1.08652074979689 0.156473488883786 no 2844 0.138624332910613 4045 2870194
SGTC_2929 9013348 24.6 µM -1.09063497121041 0.15558112420936 no 2845 0.137716767531747 4173 2995952
SGTC_408 cantharidin 100 µM -1.091332738272 0.155430113824265 no 2846 0.137563248597523 4143 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2025 5147754 141 µM -1.09156957671601 0.155378879362939 no 2847 0.137511167249018 4159 315777 YLR208W SEC13
SGTC_886 0866-0150 153 µM -1.09162644883015 0.155366578069982 no 2848 0.137498662937684 4248 271463
SGTC_1068 loratadine 26.9 µM -1.0916998376668 0.15535070520192 no 2849 0.137482528288341 4208 3957 A H1 histamine antagonist.
SGTC_2022 5136654 200 µM -1.09317476557128 0.155031928034491 no 2850 0.137158537124086 4228 1713771
SGTC_2184 6075246 200 µM -1.10298107906287 0.152923472451356 no 2851 0.1350176909879 4196 2267320
SGTC_1631 benzylvanillin 81.9 µM -1.10367801212259 0.15277435193109 no 2852 0.134866418495842 4261 75506
SGTC_159 3970-0959 50 µM -1.1045034678373 0.152597856632093 no 2853 0.134687400039736 4272 6615653
SGTC_2336 9001819 198.65 µM -1.10592473282678 0.152294285124238 no 2854 0.134379549324911 4277 2989602
SGTC_3183 9108214 49.47 µM -1.10720985498 0.152020138071889 no 2855 0.134101603853636 4131 4974831
SGTC_781 4335-2806 94.4 µM -1.10785935995443 0.151881708016495 no 2856 0.133961279646257 4263 845254
SGTC_2634 4'-methoxyflavone 100 µM -1.1086192498772 0.151719857775418 no 2857 0.133797235122363 4217 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2814 7977482 42.97 µM -1.10973777548897 0.151481829717447 no 2858 0.133556019876488 4233 6456762
SGTC_2019 4016004 108 µM -1.11108169126091 0.151196166013211 no 2859 0.133266593935949 4227 45595336
SGTC_1254 0550-0035 264 µM -1.11170653922671 0.151063470005392 no 2860 0.133132173644282 4239 15121435
SGTC_2045 5106652 78.05 µM -1.11240011960953 0.150916268395164 no 2861 0.132983076613136 4180 673349
SGTC_2784 7567673 72.73 µM -1.11687794471013 0.149968218408028 no 2862 0.132023257999738 4176 3471247
SGTC_1334 1486-0610 236 µM -1.11691233453835 0.149960952757041 no 2863 0.132015905098808 4284 3742339
SGTC_2462 5162487 171.77 µM -1.12126916207208 0.149042370043484 no 2864 0.1310866539397 4162 2259986
SGTC_2678 equilin 100 µM -1.12351858866676 0.148569580861612 no 2865 0.130608655182857 4212 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1970 st070122 35.8 µM -1.12477638145541 0.148305652928603 no 2866 0.130341902643731 4245 102928
SGTC_273 hydroxyurea 18.1 mM -1.12605424530433 0.148037834775166 no 2867 0.130071279628176 4295 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1844 rapamycin 4 nM -1.1263851248107 0.147968540946473 no 2868 0.130001270169383 4114 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1390 3413-2614 145 µM -1.1265159679905 0.147941145346755 no 2869 0.129973592787102 4243 3421432
SGTC_2710 st078562 53.7235 µM -1.12701916687549 0.14783581853159 no 2870 0.129867188657981 4162 17250908
SGTC_1779 st039427 55 µM -1.13024060328853 0.147162714991437 no 2871 0.129187427494353 4202 1124498
SGTC_3061 glucosamine 200 µM -1.13230754744133 0.146731920714906 no 2872 0.128752579061289 4155 91431 and experimental redox chemotherapeutic
SGTC_2796 7949634 45.45 µM -1.1328615320269 0.146616602696281 no 2873 0.128636203278375 4196 2971588
SGTC_2649 anisomycin 9.56 µM -1.13286523032511 0.146615833059033 no 2874 0.128635426620611 4249 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_84 0443-0269 128.823 µM -1.13330642472552 0.146524037406898 no 2875 0.128542797338014 4142 6150058
SGTC_2255 7941087 197.44 µM -1.13462835677931 0.146249224987321 no 2876 0.12826553334699 4330 935561
SGTC_2473 5854593 8.94 µM -1.13973083405507 0.145191734691619 no 2877 0.127199228528564 4117 2872951
SGTC_2890 9046729 58.44 µM -1.14099173214587 0.144931207935892 no 2878 0.126936681801193 4185 903329
SGTC_2913 7966556 36.57 µM -1.1415342156632 0.144819216886291 no 2879 0.126823840932466 4117 2976516
SGTC_2914 7968218 45.32 µM -1.14409731261708 0.144290875827174 no 2880 0.126291641033284 4205 2977111
SGTC_588 3970-1144 52.9 µM -1.14702528364767 0.143688913620759 no 2881 0.125685585745683 4109 1888707
SGTC_326 k292-0812 17.5 µM -1.14907769680955 0.14326796926736 no 2882 0.125261972051005 4234 3579357
SGTC_903 1134-0042 114 µM -1.14992003616232 0.143095449046509 no 2883 0.125088403848681 4244 701009
SGTC_230 MPP+ 141.667 µM -1.15126748341488 0.142819769188469 no 2884 0.12481110504218 4204 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.15135203213439 0.142802482990778 no 2885 0.124793719615325 4139 6708630 An antioxidant.
SGTC_3265 9137266 49.47 µM -1.15277414796242 0.142511939792101 no 2886 0.124501549016563 4185 17224265
SGTC_2393 9031399 185.94 µM -1.15474241505385 0.142110476003952 no 2887 0.124097962362873 4280 1526623 YDL150W RPC53
SGTC_1273 0849-0096 14.1 µM -1.15553790785078 0.141948438223456 no 2888 0.123935109213233 4270 5286025
SGTC_3318 9139014 38.6185 µM -1.15690171072936 0.141670929770243 no 2889 0.123656259860957 4247 16643984
SGTC_2916 7875993 68.79 µM -1.16271123879133 0.140492918053579 no 2890 0.122473340093183 4089 1299250
SGTC_2351 9026858 72.31 µM -1.16961640556411 0.139101413243451 no 2891 0.121077686137525 4157 1409300
SGTC_1058 3448-5425 97.3 µM -1.17114582339525 0.138794483716146 no 2892 0.120770083760354 4197 7279705
SGTC_638 3970-0837 4.09 µM -1.1732239945174 0.13837816790372 no 2893 0.120352996139608 4240 4118451 YLR208W SEC13
SGTC_2298 7976326 193.81 µM -1.17492791071944 0.138037461443761 no 2894 0.120011779060524 4170 2235818
SGTC_3284 9108171 64.8615 µM -1.17506972225075 0.138009131339093 no 2895 0.119983411413984 4240 8687505
SGTC_1186 1319-0216 26 µM -1.17619330575297 0.137784809957925 no 2896 0.119758819470601 4347 4565136
SGTC_2117 5521686 200 µM -1.17750652835768 0.137522942954742 no 2897 0.11949669668803 4228 803312
SGTC_249 wiskostatin 11.211 µM -1.17821624275744 0.137381561789012 no 2898 0.119355204375333 4250 2775510 A n-wasp and actin depolymerizer.
SGTC_882 0843-0131 351 µM -1.17904180421733 0.137217227812591 no 2899 0.119190764993525 4266 5425421
SGTC_3303 9125618 40.5795 µM -1.18285513766614 0.136459899089165 no 2900 0.118433282014692 4277 22695467
SGTC_1025 k007-0731 70 µM -1.18679091525675 0.135681256396383 no 2901 0.117655051574818 4237 6256118
SGTC_816 0325-0417 81.3 µM -1.18739780531972 0.135561462413164 no 2902 0.117535372639006 4294 68101
SGTC_1921 5740136 50 µM -1.18819112992252 0.135404977437306 no 2903 0.11737905874886 4223 1774243
SGTC_1792 st045773 43.6 µM -1.19123137889822 0.134806428394885 no 2904 0.116781382102058 4226 2919270
SGTC_2819 7996655 46.38 µM -1.19125235135558 0.134802305756608 no 2905 0.116777266673809 4231 6456960
SGTC_2248 tofa 1.1 µM -1.19133072790906 0.1347868997355 no 2906 0.116761887741813 4266 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3100 9120536 49.47 µM -1.19304303067356 0.13445062386884 no 2907 0.116426260504893 4141 16421196
SGTC_1830 st055982 50.3 µM -1.19350737183286 0.134359532159926 no 2908 0.116335363399501 4246 455313 An antimicrobial agent.
SGTC_1173 0443-0020 122 µM -1.19447629789536 0.134169590463561 no 2909 0.116145853447808 4270 5331295
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.19520205912859 0.134027438029456 no 2910 0.116004047121726 4272 688669
SGTC_2991 9074669 71.4286 µM -1.19637617203137 0.133797687637956 no 2911 0.115774897799747 4269 17333109
SGTC_3031 9088762 49.47 µM -1.19822005197709 0.133437423926681 no 2912 0.115415680520404 4250 205253
SGTC_443 clozapine 122 µM -1.19879657785248 0.133324917339845 no 2913 0.115303526780846 4250 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.19910375223087 0.133265000215152 no 2914 0.115243802639667 4278 229346 A bile salt which induces apoptosis.
SGTC_2407 paclitaxel 400 µM -1.20265661719417 0.132573328308318 no 2915 0.11455461423566 4368 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2363 9053361 176 µM -1.2056009031187 0.132002011746833 no 2916 0.113985705407247 4349 6469797 YMR079W SEC14
SGTC_2093 5331342 194.4 µM -1.20633435194947 0.131859956081476 no 2917 0.113844298676593 4345 33839
SGTC_2847 9005661 71.43 µM -1.20838573580453 0.131463200536117 no 2918 0.11344946195953 4325 2991449
SGTC_1784 st039334 36.3 µM -1.2087377639473 0.131395198154852 no 2919 0.113381804214083 4328 3496984
SGTC_3004 9076122 71.4286 µM -1.20936084730809 0.131274894730754 no 2920 0.113262121800879 4310 44782551
SGTC_2829 7992743 58.44 µM -1.21131131097566 0.130898795775432 no 2921 0.112888057679677 4295 16462845
SGTC_2866 9034245 58.44 µM -1.21329140631256 0.130517745434221 no 2922 0.112509213674726 4296 6462273
SGTC_2863 9028737 58.44 µM -1.2151682738082 0.130157269090039 no 2923 0.112150959068364 4276 6460917
SGTC_3093 9117344 49.47 µM -1.21624141572479 0.129951468356639 no 2924 0.111946485574992 4311 24824913
SGTC_716 1683-5115 658 µM -1.21634083696037 0.129932413355095 no 2925 0.111927555628409 4281 723597
SGTC_2744 captopril 92.04 µM -1.21816280456093 0.129583558866838 no 2926 0.111581055624067 4366 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_439 amiodarone 34.4 µM -1.22149213001052 0.128947765895491 no 2927 0.110949871787359 4169 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1483 3453-0561 55.9 µM -1.23100801748196 0.127142481708806 no 2928 0.109159932838132 4343 4546991
SGTC_385 1494-0393 12.4 µM -1.23111649083642 0.127122004828337 no 2929 0.10913964931492 4283 3090647
SGTC_935 2996-0153 430 µM -1.23160299974938 0.127030193129761 no 2930 0.109048709921091 4307 23738523
SGTC_1668 st014914 51.6 µM -1.23269931182115 0.126823471410358 no 2931 0.108843984346585 4321 2839556
SGTC_2151 5563267 85.4165 µM -1.2349080353524 0.126407703803916 no 2932 0.108432366294856 4370 5310824
SGTC_836 0330-0104 1.35 µM -1.2355825749654 0.126280918747373 no 2933 0.108306882528537 4339 46494820
SGTC_2765 myclobutanil 7.74 µM -1.23877216880463 0.12568260973703 no 2934 0.107714941727574 4340 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2567 aureobasidin a 60 nM -1.24270917235885 0.124946831308149 no 2935 0.106987511343057 4434 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1291 0993-0025 5.79 µM -1.24353427374359 0.124793012002851 no 2936 0.106835509606958 4317 4353356
SGTC_3202 9113761 49.47 µM -1.24408526777449 0.124690366803961 no 2937 0.106734091253367 4268 4798415
SGTC_2056 5235370 200 µM -1.24534082504539 0.124456688326487 no 2938 0.106503247517734 4236 5511916
SGTC_2361 9034121 116 µM -1.24606325745734 0.124322371433365 no 2939 0.106370586311179 4340 6496917
SGTC_3246 9135460 32.98 µM -1.24661215238685 0.124220386971186 no 2940 0.106269871821961 4297 41446951
SGTC_1943 st076331 65.2 µM -1.24880612176742 0.123813332822117 no 2941 0.105867997174465 4314 24208415
SGTC_565 1418-0001 44.5 µM -1.25030905321562 0.123535028615516 no 2942 0.105593336282634 4380 2862145
SGTC_1870 st057514 26.5 µM -1.25212234764033 0.123199836741668 no 2943 0.105262642845713 4328 5393161
SGTC_2488 5268135 45.7 µM -1.25339459813238 0.122965038957295 no 2944 0.105031068200813 4367 1270356 YLR208W SEC13
SGTC_2837 9008476 45.46 µM -1.25363414409846 0.122920865124166 no 2945 0.104987507401287 4311 2992805
SGTC_1578 josamycin 24.2 µM -1.25756654515823 0.122197295010713 no 2946 0.104274279361596 4332 5282165 A P450 substrate.
SGTC_863 0466-0191 129 µM -1.25813898725477 0.122092214303707 no 2947 0.10417074782446 4383 765160 YPR165W RHO1
SGTC_125 0133-0007 11.75 µM -1.25846472649807 0.122032448101014 no 2948 0.104111868094862 4408 26541
SGTC_1011 4112-3381 17.4 µM -1.25945830354031 0.121850274833709 no 2949 0.103932420888807 4386 2877139
SGTC_3105 9121040 49.47 µM -1.26143398873827 0.121488598977938 no 2950 0.103576264520324 4260 41448907
SGTC_2452 5863136 48.41 µM -1.2631669066482 0.121171986770146 no 2951 0.103264601590477 4276 2184096
SGTC_697 0508-1955 564 µM -1.26580742376082 0.120690668615132 no 2952 0.102791018301306 4331 6243113
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.26663778443504 0.120539587545801 no 2953 0.102642417756843 4282 1241132 A phosphatase inhibitor.
SGTC_797 k781-0471 270 µM -1.269073639288 0.120097161225553 no 2954 0.102207400541065 4309 23738129
SGTC_2129 girgensonine 121.053 µM -1.27366579348764 0.119266199552844 no 2955 0.101390942070794 4358 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3190 9110366 49.47 µM -1.27408365773321 0.119190787901133 no 2956 0.101316884729799 4341 17123768
SGTC_1383 3049-0032 20.7 µM -1.27762448310595 0.118553128547414 no 2957 0.100690931831869 4408 712864
SGTC_1038 k292-0204 154 µM -1.27935193159026 0.118242912703466 no 2958 0.100386576391007 4292 4454212
SGTC_841 0251-0215 91.2 µM -1.28048572607326 0.11803961770592 no 2959 0.100187180822583 4381 3888614
SGTC_1791 st048313 56.1 µM -1.2806450013685 0.118011078669059 no 2960 0.100159192936863 4360 1204976
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.28116151399372 0.117918563226264 no 2961 0.100068470506602 4383 5393153
SGTC_1119 parthenolide 318.541 nM -1.28437173184115 0.117344713749605 no 2962 0.099505959490204 4421 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2756 carbadox 75.1 µM -1.28666434443476 0.116936105215097 no 2963 0.099105652946309 4297 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2246 7293507 91.5585 µM -1.28699379406292 0.116877470921396 no 2964 0.0990482256111802 4417 887656
SGTC_3261 9137475 49.47 µM -1.28781007368827 0.116732282116802 no 2965 0.0989060423794983 4324 17027690
SGTC_2000 st075254 36.4 µM -1.28897190491714 0.116525851852634 no 2966 0.0987039270407842 4248 17234175
SGTC_1917 st066507 28.5 µM -1.29159033093907 0.116061568354036 no 2967 0.0982495271457909 4300 3156428
SGTC_1671 st016596 74.5 µM -1.29248268719149 0.115903641540271 no 2968 0.0980950188549042 4412 2829167
SGTC_2891 9063876 19.48 µM -1.29402863453402 0.115630405189006 no 2969 0.0978277651000716 4389 6472478
SGTC_1403 3909-7815 62.9 µM -1.29440027803964 0.115564787844046 no 2970 0.097763597332761 4332 6615483
SGTC_1346 1488-2224 62.4 µM -1.29807534122874 0.114917342986336 no 2971 0.0971307234114588 4381 3722427
SGTC_446 go6976 132 µM -1.29916087485633 0.114726596409261 no 2972 0.0969443627245311 4391 3501 A protein kinase C inhibitor.
SGTC_2886 9058944 51.95 µM -1.30031614878674 0.114523842852304 no 2973 0.0967463177459222 4280 4949929
SGTC_3287 9117173 37.0625 µM -1.30080593258757 0.114437961560657 no 2974 0.0966624453930526 4373 2789709
SGTC_1766 st045414 44.774 µM -1.30471394563506 0.113754351879369 no 2975 0.095995135508341 4373 253960
SGTC_3224 9130643 49.47 µM -1.30548017911408 0.113620660385046 no 2976 0.0958646960446881 4420 17644395
SGTC_2241 6772625 37.8075 µM -1.30713077863038 0.113333046416204 no 2977 0.0955841498526113 4171 2285411
SGTC_1529 apigenin 74 µM -1.31227596389942 0.112439840680107 no 2978 0.094713519534741 4386 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.31544108937553 0.111892878638783 no 2979 0.0941808519108922 4429 368090
SGTC_3179 9107801 49.47 µM -1.31560178808798 0.111865159303957 no 2980 0.0941538665534956 4374 4818259
SGTC_1755 st041960 45.185 µM -1.31595170655052 0.111804817956842 no 2981 0.0940951261726514 4394 2257073
SGTC_135 0933-0004 26.348 µM -1.32287409082796 0.110615876785916 no 2982 0.0929386263996175 4329 21230617 YGL099W LSG1
SGTC_406 estrone 100 µM -1.32904772734568 0.109563203844592 no 2983 0.0919161121387471 4357 5870 A steroid.
SGTC_1397 3532-0190 20.1 µM -1.3290730399395 0.109558902627564 no 2984 0.0919119369366386 4337 5322280
SGTC_90 0870-0863 4.608 µM -1.33012130502049 0.109380883711115 no 2985 0.0917391535077412 4398 1738164
SGTC_806 3966-4455 5.86 µM -1.33036003946324 0.109340370313421 no 2986 0.0916998370516385 4361 714982
SGTC_519 k048-0011 62.8 µM -1.3328058527337 0.108925934932795 no 2987 0.0912977622838382 4405 6836379
SGTC_641 4092-0595 30 µM -1.33373188826302 0.108769316208849 no 2988 0.091145870068975 4442 786260
SGTC_354 2783-3500 4.88 µM -1.33378245965774 0.108760767825245 no 2989 0.0911375805374044 4391 6740761
SGTC_295 k015-0027 31 µM -1.33998122546235 0.107716609600564 no 2990 0.0901257243988462 4456 3887424
SGTC_1935 st074532 41.6 µM -1.3406903857144 0.107597616213063 no 2991 0.0900104986803644 4361 2829742
SGTC_874 0599-0792 117 µM -1.34287083081787 0.10723234231326 no 2992 0.0896569015073601 4390 765305
SGTC_277 nystatin 15.5 µM -1.34496991897933 0.106881543033596 no 2993 0.0893174744915562 4416 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2745 rifampicin 24.3 µM -1.35079500026919 0.105912395040394 no 2994 0.0883805550602206 4488 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2908 7930301 100 µM -1.35197346871568 0.105717102165718 no 2995 0.0881919014114488 4357 2223178
SGTC_672 1441-0018 53.7 µM -1.35513645036607 0.10519422805132 no 2996 0.0876870436539043 4410 251141
SGTC_2661 dactinomycin 12.96 µM -1.35674432425047 0.104929148168547 no 2997 0.0874312317544318 4369 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2654 protoveratrine a 100 µM -1.35804972184742 0.104714291561659 no 2998 0.0872239537035548 4433 5702278 A heart drug and vasodilator.
SGTC_2588 indole-3-carbinol 100 µM -1.36415474471846 0.103713689242429 no 2999 0.0862594339826072 4415 3712 Induces cell cycle arrest.
SGTC_2507 purpurin 79.67 µM -1.36463199477483 0.103635762144459 no 3000 0.0861843717586742 4404 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2026 5148700 152 µM -1.36691947542063 0.103262843914571 no 3001 0.0858252734065089 4391 79838
SGTC_584 0986-0246 15.4 µM -1.36796508596309 0.103092707325354 no 3002 0.0856615024973545 4497 53315 YDR232W HEM1
SGTC_282 k297-0036 65.7 µM -1.36831618924184 0.103035623216953 no 3003 0.0856065627275467 4414 5061378
SGTC_974 1326-0144 138 µM -1.36919389643794 0.102893021682143 no 3004 0.0854693367058854 4440 5411856
SGTC_1337 1486-1011 40.3 µM -1.37072397208033 0.102644772478146 no 3005 0.0852305095091563 4391 X1337
SGTC_3339 9145883 14.936 µM -1.37134218105982 0.10254459390377 no 3006 0.0851341561568676 4335 2030670
SGTC_466 geldanamycin 89.2 µM -1.37250880678919 0.102355740003717 no 3007 0.0849525495938517 4429 5288382 HSP90 inhibitor.
SGTC_2011 4012611 177 µM -1.37369857303391 0.102163400748519 no 3008 0.0847676400448513 4384 2049887
SGTC_1817 st052116 64.4 µM -1.37606609071666 0.10178144700421 no 3009 0.0844005863094006 4451 4361398
SGTC_2888 9058547 12.99 µM -1.37670052157433 0.101679270537953 no 3010 0.0843024287154166 4346 16476514
SGTC_2808 7946468 45.46 µM -1.37749831703795 0.10155088987842 no 3011 0.0841791173801221 4402 2970879
SGTC_384 k007-0144 5.16 µM -1.38031290937567 0.101098910653604 no 3012 0.0837451609526723 4358 6824886
SGTC_2127 5253358 187.912 µM -1.38358155919817 0.10057585906982 no 3013 0.0832433090442978 4348 20612
SGTC_1251 0490-5699 265 µM -1.38556620664741 0.100259239162496 no 3014 0.0829397015382857 4443 3883818
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.38729285476911 0.0999843714066458 no 3015 0.0826762405076452 4500 4213774
SGTC_359 0081-0058 15.9 µM -1.39350583176733 0.0989998709639975 no 3016 0.0817334413772273 4465 3494159
SGTC_1079 idarubicin 2.36 µM -1.3955767949599 0.0986732897613836 no 3017 0.0814209871496354 4446 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_13 0199-0087 65 µM -1.39943376064882 0.0980671674029219 no 3018 0.0808414744257835 4543 4589825
SGTC_949 1165-0505 146 µM -1.40101212001726 0.0978199163343799 no 3019 0.0806052244090205 4415 6244267
SGTC_1820 st053765 18.6 µM -1.40340136362153 0.0974465095674815 no 3020 0.0802485933017885 4465 3690829
SGTC_3068 9116768 49.47 µM -1.4038532244591 0.0973760074930923 no 3021 0.0801812804665182 4400 41904888
SGTC_2443 5493264 126.67 µM -1.40484592904912 0.0972212511072334 no 3022 0.0800335490654586 4466 5340055
SGTC_3349 9149703 23.001 µM -1.40512068833176 0.0971784497732644 no 3023 0.0799926965744239 4451 4910494
SGTC_968 1309-0633 340 µM -1.40903582485124 0.0965700609680075 no 3024 0.0794122876128555 4472 3761976
SGTC_1259 0671-0132 43 µM -1.40925315772446 0.0965363708968471 no 3025 0.0793801621957731 4377 X1259
SGTC_183 3914-0051 30.55 µM -1.41092380839251 0.0962776815899165 no 3026 0.0791335405736535 4431 1596232
SGTC_3118 9124250 49.47 µM -1.41197991498749 0.0961144134660615 no 3027 0.0789779375979914 4393 1504786
SGTC_964 1287-0107 19.4 µM -1.42206692840755 0.0945652643264963 no 3028 0.0775034112065802 4431 51516812 YPR165W RHO1
SGTC_2802 7925815 54.55 µM -1.42214946680153 0.0945526645727862 no 3029 0.0774914325173805 4429 1262923
SGTC_1898 st060199 18.6 µM -1.4229682925193 0.0944277352035812 no 3030 0.0773726735595143 4427 688866
SGTC_763 3453-1109 128 µM -1.42400805349653 0.0942692728974648 no 3031 0.0772220703901868 4482 1560353
SGTC_3219 9131112 49.47 µM -1.42508819872804 0.0941048637260171 no 3032 0.077065853772384 4318 17612988 YMR079W SEC14
SGTC_673 1082-0474 110 µM -1.43067660744823 0.0932576282428315 no 3033 0.0762614602539173 4446 3098046
SGTC_1630 st005209 31.3 µM -1.43106385900458 0.0931991281216708 no 3034 0.0762059570271265 4446 3367314
SGTC_604 1000-0114 314 µM -1.43154012455694 0.0931272182980842 no 3035 0.0761377379422471 4464 1572745
SGTC_2730 imipramine 71.33 µM -1.43302886991232 0.0929027017889415 no 3036 0.0759247935368244 4418 3696 A tricyclic antidepressant.
SGTC_2550 chrysin dimethyl ether 71.87 µM -1.4347015072688 0.0926509303404017 no 3037 0.0756860872632049 4302 88881 An O-methylated flavonoid and antioxidant.
SGTC_1154 4088-0362 150 µM -1.43595526471357 0.0924625413973433 no 3038 0.0755075355934619 4460 6618304
SGTC_1997 st073024 93.8 µM -1.43749032600518 0.0922322700110106 no 3039 0.0752893598360696 4500 686268
SGTC_2475 5812728 15.03 µM -1.43780896868762 0.0921845243247244 no 3040 0.0752441319622453 4405 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_3096 9117468 49.47 µM -1.4390692971677 0.0919958549476635 no 3041 0.075065444969297 4417 41316311
SGTC_2787 5284540 71.43 µM -1.43972284195491 0.0918981328758698 no 3042 0.0749729141261448 4469 736958
SGTC_2902 5787006 60.46 µM -1.4399577769847 0.0918630227247913 no 3043 0.0749396725821838 4426 591003
SGTC_3065 9113888 49.47 µM -1.44423871965293 0.0912249909454156 no 3044 0.07433591840346 4487 16648368
SGTC_2561 acetosyringone 100 µM -1.44458106724781 0.0911741096997472 no 3045 0.0742877969506432 4405 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1980 st071811 45.7 µM -1.44492208329778 0.0911234472795635 no 3046 0.0742398863178638 4525 4974850
SGTC_1231 0242-0792 125 µM -1.44693866157809 0.0908242847473631 no 3047 0.0739570518622234 4453 3707635
SGTC_3136 9095672 49.47 µM -1.44944223026963 0.090453891216499 no 3048 0.073607061212475 4335 17217380
SGTC_2667 digitoxin 100 µM -1.4511494577403 0.0902019572901227 no 3049 0.0733691235886133 4423 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1158 4092-0494 91.8 µM -1.45311326575866 0.0899128050635897 no 3050 0.0730961542072089 4552 1148199
SGTC_1335 1486-0900 202 µM -1.45629849958698 0.0894452750641671 no 3051 0.0726550600694823 4464 X1335
SGTC_957 1187-1561 14.1 µM -1.46410288843208 0.0883073901261752 no 3052 0.0715829191008276 4426 1538454
SGTC_1531 st059297 52.4 µM -1.46577752282254 0.0880646393232731 no 3053 0.0713544532285403 4511 7566702
SGTC_3011 9081274 71.4286 µM -1.47200696124605 0.0871660025331221 no 3054 0.0705094988835715 4479 6625322
SGTC_2193 5925765 200 µM -1.47223815748678 0.0871327832551732 no 3055 0.0704782883412911 4483 877370
SGTC_605 1315-0399 119 µM -1.47234906265654 0.0871168512754721 no 3056 0.0704633203689674 4556 24020461
SGTC_3001 9076041 71.4286 µM -1.4725348629242 0.0870901651851475 no 3057 0.0704382498887123 4486 16004211
SGTC_2696 st077691 74.316 µM -1.47590892919624 0.0866066168776514 no 3058 0.0699841710534851 4497 757133
SGTC_657 3534-0529 86.7 µM -1.47894038180604 0.0861738836267102 no 3059 0.0695781247073439 4509 1049549
SGTC_751 0833-0568 350 µM -1.47958808589096 0.0860816353418784 no 3060 0.0694916039734189 4489 6954252
SGTC_477 mead ethanolamide 10 µM -1.4805015858947 0.085951657076592 no 3061 0.0693697189060479 4484 16061185
SGTC_1649 st011737 51.3 µM -1.48564804740229 0.0852221308500373 no 3062 0.0686861195520311 4507 1761035
SGTC_559 1550-0661 158 µM -1.48702094620412 0.085028304506945 no 3063 0.0685046394275455 4525 5830875
SGTC_1031 k035-0009 16 µM -1.48774373434603 0.0849263938770799 no 3064 0.0684092445833499 4531 5180959
SGTC_2176 5809774 33.9695 µM -1.4902995676933 0.0845667645220914 no 3065 0.0680727430613001 4403 2870539
SGTC_3252 9135871 49.47 µM -1.49483784815277 0.0839310035282813 no 3066 0.0674783829923765 4510 17682838
SGTC_1368 1852-0141 284 µM -1.49554858154507 0.0838317638602138 no 3067 0.0673856654677153 4470 2838987
SGTC_1704 st028805 70.8 µM -1.49714919231307 0.0836085934270763 no 3068 0.0671772211032063 4538 2876101
SGTC_2645 abamectin 100 µM -1.50287592526449 0.0828137799176605 no 3069 0.0664355211258339 4443 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_45 0kpi-0036 14.9 µM -1.50348215916975 0.0827299745808085 no 3070 0.0663573770879346 4469 2795021
SGTC_3311 9131146 2.8755 µM -1.50361975394733 0.0827109624675802 no 3071 0.0663396509246575 4439 4900406 YPR165W RHO1
SGTC_102 gallobenzophenone 83.616 µM -1.5053118404843 0.0824774277358215 no 3072 0.0661219612291516 4475 70837
SGTC_2416 tofa 880 nM -1.50726761133818 0.0822081192744422 no 3073 0.0658710380098348 4440 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_108 0509-0257 621.132 µM -1.50871398103393 0.0820093814614986 no 3074 0.0656859455477864 4460 536624
SGTC_3017 9080681 49.47 µM -1.51766237221656 0.0807878718439504 no 3075 0.0645497672038078 4524 16451914
SGTC_1790 st045711 43.5 µM -1.51770546467022 0.0807820228834971 no 3076 0.0645443329233498 4485 585119
SGTC_2843 9000894 45.46 µM -1.51772596200544 0.0807792408820748 no 3077 0.0645417481809223 4494 2242070
SGTC_3030 9087619 49.47 µM -1.51876022680936 0.0806389591604531 no 3078 0.0644114303138877 4515 25236973
SGTC_217 ketoconazole 989 nM -1.519688670894 0.0805131871382104 no 3079 0.0642946201357025 4309 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2533 agelasine 13.65 µM -1.52456276568852 0.0798553459946453 no 3080 0.0636840952215215 4535 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_607 4491-0986 66.8 µM -1.52603484587521 0.0796574654165619 no 3081 0.0635005933006196 4506 698981 YDR232W HEM1
SGTC_1096 rimcazole 32.2 µM -1.52637010972632 0.0796124503474688 no 3082 0.0634588586260191 4456 18528119 A dopamine reuptake inhibitor.
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.5263802839851 0.0796110845752347 no 3083 0.0634575924368599 4498 803109
SGTC_3095 9117207 49.47 µM -1.52739868055238 0.0794744667232186 no 3084 0.0633309521785436 4508 17015229
SGTC_1426 4048-4480 71.7 µM -1.52762962591353 0.079443510107963 no 3085 0.0633022609090877 4511 14224343
SGTC_2771 fluoxetine 41.05 µM -1.52961411228324 0.0791778795706411 no 3086 0.0630561371043531 4500 3386 A selective serotonin reuptake inhibitor.
SGTC_610 4215-0184 155 µM -1.53027958821018 0.079088953993304 no 3087 0.0629737692475442 4521 5605015
SGTC_2659 sanguinarine 24.21 µM -1.53139149007035 0.0789405426288891 no 3088 0.0628363330175419 4473 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2389 9091542 195.52 µM -1.53210907419186 0.0788448749825708 no 3089 0.0627477604475812 4470 3626624 YOL127W RPL25
SGTC_685 1278-0033 54.9 µM -1.53387537654202 0.0786097674221275 no 3090 0.0625301573753715 4566 3590572
SGTC_2519 cryptotanshinone 88.04 µM -1.53561788698722 0.0783783477828688 no 3091 0.062316062306504 4509 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1461 k072-0203 53.8 µM -1.53593156855027 0.0783367432267478 no 3092 0.0622775823380487 4401 5418714
SGTC_2461 5755302 26.15 µM -1.53888875776623 0.0779453448106604 no 3093 0.0619157281027751 4524 2788904
SGTC_2466 5983409 37.09 µM -1.53995027238406 0.0778052106886478 no 3094 0.0617862376232337 4508 2879657
SGTC_942 3253-1115 227 µM -1.54073505726838 0.0777017315946096 no 3095 0.0616906404369935 4539 46497897
SGTC_3034 9090421 49.47 µM -1.54312262786099 0.0773875569679713 no 3096 0.0614005127413912 4435 17173761
SGTC_1506 4226-2149 212 µM -1.54339663208212 0.0773515632236145 no 3097 0.061367285175138 4518 991114
SGTC_2435 5706476 10.6 µM -1.54477915021704 0.0771701467890255 no 3098 0.0611998460722979 4499 5725375
SGTC_655 k060-0012 42 µM -1.54758234311403 0.0768032995053487 no 3099 0.0608614426170284 4507 5994525
SGTC_124 0136-0217 7.121 µM -1.54833253052173 0.076705349495189 no 3100 0.0607711280795222 4564 3976905
SGTC_1962 st076595 64.5 µM -1.55840989034545 0.0753987676088166 no 3101 0.0595680567925365 4490 279619
SGTC_2739 tacrine 100.86 µM -1.56106693224863 0.0750571104839546 no 3102 0.0592539796448728 4584 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2797 7859098 81.82 µM -1.56128802682266 0.0750287342186944 no 3103 0.0592279036682341 4490 972681
SGTC_179 1273-0063 6.77 µM -1.56183126031859 0.0749590479540557 no 3104 0.0591638727244788 4502 3108139
SGTC_55 0767-0285 6.563 µM -1.56318198204749 0.0747859906895534 no 3105 0.0590048984412679 4449 3116166
SGTC_2034 5197015 53.07 µM -1.56516734352959 0.0745321756247262 no 3106 0.0587718382387894 4529 780676
SGTC_2378 9074213 121.43 µM -1.56767482007765 0.0742125519825507 no 3107 0.0584785204830569 4508 657714
SGTC_732 3970-1727 52.7 µM -1.57441357187354 0.0733587624775274 no 3108 0.0576959341037865 4596 1275699
SGTC_2759 disulfiram 3.38 µM -1.57599721530552 0.0731592118312636 no 3109 0.0575132224867736 4442 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_659 k018-0002 107 µM -1.57711905194638 0.0730181037274033 no 3110 0.0573840670972445 4504 6797879 YHR007C ERG11
SGTC_2396 5342950 42.78 µM -1.57736799741421 0.0729868188509762 no 3111 0.0573554373362688 4526 1886677
SGTC_422 cantharidin 155 µM -1.58646292044865 0.0718508838946439 no 3112 0.0563171685110907 4446 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3307 9126885 69.2785 µM -1.58763603761268 0.0717053569105784 no 3113 0.0561843321162285 4509 24824909
SGTC_1729 st035615 45.989 µM -1.58967156984176 0.0714533826918603 no 3114 0.0559544276456959 4529 17385451
SGTC_356 1634-0012 32.5 µM -1.59120907820914 0.0712635086928432 no 3115 0.0557812652518129 4538 735457
SGTC_368 fentichlor 4.58 µM -1.59479528172899 0.070822137482028 no 3116 0.0553790112539239 4536 7329 A pesticide.
SGTC_2741 miltefosine 3.04 µM -1.59935168081358 0.0702643926814092 no 3117 0.0548712411103107 4581 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1344 1488-0097 29.1 µM -1.59951138570353 0.0702449047974924 no 3118 0.054853510393864 4576 747966
SGTC_2105 5350118 200 µM -1.60114738787598 0.0700455120341622 no 3119 0.054672139256813 4532 2133313
SGTC_116 0155-0182 31.788 µM -1.60576231193856 0.0694854004715931 no 3120 0.0541630721616723 4415 771486
SGTC_1147 3809-1045 12.3 µM -1.60628000261434 0.0694227843237761 no 3121 0.0541062010551303 4566 325925
SGTC_1444 4112-3581 28 µM -1.60658668675874 0.0693857105146956 no 3122 0.0540725324501604 4627 2877249
SGTC_1493 4348-0038 111 µM -1.60696765613071 0.0693396779035636 no 3123 0.0540307317110941 4540 800424
SGTC_2951 9072950 58.06 µM -1.60714875140962 0.0693178043726663 no 3124 0.0540108705379138 4467 16488155
SGTC_1371 2421-0008 32.7 µM -1.60797757380274 0.069217763170721 no 3125 0.0539200452506325 4546 2827552
SGTC_1717 st033143 58.0435 µM -1.61124742818054 0.0688241673541854 no 3126 0.0535629020927185 4559 674616
SGTC_1451 4152-0210 104 µM -1.61289793056145 0.0686261510821981 no 3127 0.0533833424399168 4580 659563
SGTC_3071 9117417 49.47 µM -1.6156688484465 0.0682947032611523 no 3128 0.0530829648066923 4506 45595590 YGL055W OLE1
SGTC_1642 st009582 77.7 µM -1.61889328650998 0.0679105636199586 no 3129 0.0527351128034642 4540 6739311
SGTC_1243 0416-0003 5.65 µM -1.62046296545066 0.0677241666176908 no 3130 0.052566431796486 4529 2141977
SGTC_2477 5967686 25.23 µM -1.62425051663397 0.0672760280762818 no 3131 0.0521611767115518 4548 776118
SGTC_3254 9136651 49.47 µM -1.62722654193112 0.0669255193849985 no 3132 0.0518444963041991 4528 16454030
SGTC_2766 oltipraz 83.91 µM -1.6272970208037 0.0669172357187752 no 3133 0.0518370151730789 4526 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_465 cgp-37157 41 µM -1.62735428805332 0.0669105054519806 no 3134 0.0518309370498142 4622 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.62765602362304 0.0668750529783309 no 3135 0.0517989213630601 4556 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3305 9127027 53.8275 µM -1.62922366795486 0.066691096167257 no 3136 0.0516328391680878 4518 41905295
SGTC_3351 9150312 21.596 µM -1.62980021333492 0.0666235394468421 no 3137 0.051571864350014 4476 4904905
SGTC_2064 5220758 200 µM -1.63095858024703 0.0664879678972679 no 3138 0.0514495297971153 4575 788518
SGTC_3149 9097855 49.47 µM -1.63170347745522 0.0664009004067469 no 3139 0.0513709835744205 4547 25236625 YMR079W SEC14
SGTC_2032 5185112 25.99 µM -1.63562740744794 0.0659437075333057 no 3140 0.0509587953385236 4446 5718189
SGTC_3270 9137563 49.47 µM -1.63879428108892 0.0655765042398437 no 3141 0.0506280553141806 4566 17015724
SGTC_2692 st077426 47.7 µM -1.64041357492083 0.065389358552106 no 3142 0.0504596023514567 4553 25238571
SGTC_2738 aclarubicin 5.55 µM -1.64321379827762 0.0650667079417125 no 3143 0.0501693529979309 4605 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1345 1488-0192 31.4 µM -1.64689345977414 0.0646446059410691 no 3144 0.0497899732220774 4601 658348
SGTC_901 1112-0062 60.1 µM -1.64853380680859 0.0644571248731879 no 3145 0.0496215896312858 4555 1908457
SGTC_548 1436-0017 110 µM -1.65158494535072 0.0641095234377099 no 3146 0.0493095955382133 4601 9677137
SGTC_1965 Pectolinarigenin 58.4 µM -1.65273199823518 0.0639792228085343 no 3147 0.049192709552747 4563 5320438 An anti-inflammatory.
SGTC_958 1222-0007 33 µM -1.65378947629717 0.0638592800459379 no 3148 0.0490851474715477 4610 7312461
SGTC_376 3970-0862 59.1 µM -1.65386745294221 0.0638504425973459 no 3149 0.0490772234683585 4582 3135186
SGTC_825 1988-2224 89.6 µM -1.67000307575375 0.0620420971339063 no 3150 0.0474593775333413 4568 1180859
SGTC_1098 clofazimine 15.1 µM -1.67104881692068 0.0619262923662648 no 3151 0.0473560179257659 4617 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1138 3761-0006 1.03 µM -1.6730669890204 0.0617032781661676 no 3152 0.0471570546157975 4605 12061087
SGTC_1400 3771-8998 51.5 µM -1.67443021154808 0.0615529930664722 no 3153 0.0470230397008505 4537 670767
SGTC_2608 thymoquinone 42.66 µM -1.6758254774307 0.0613994715941106 no 3154 0.046886191096293 4536 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1364 1653-0028 37.6 µM -1.6803042848282 0.0609086877502616 no 3155 0.046449063910403 4591 5718652
SGTC_1214 0358-0031 63.7 µM -1.68214402830324 0.0607079811437451 no 3156 0.0462704572755083 4587 4301366
SGTC_905 2-aminofluorene 215 µM -1.68324549666167 0.0605880643609853 no 3157 0.0461637883197132 4598 1539 An established DNA mutagen. YPR165W RHO1
SGTC_22 0964-0034 14.468 µM -1.68398274510607 0.0605079037523923 no 3158 0.0460925017325067 4584 138402
SGTC_2444 5485484 36.41 µM -1.68918154338853 0.059944994769873 no 3159 0.0455923224207116 4615 6790631
SGTC_485 niflumic acid 177 µM -1.6904993066084 0.059802965220458 no 3160 0.0454662353988935 4622 4488 A COX2 inhibitor.
SGTC_879 0831-1030 162 µM -1.7008674267082 0.0586946596374089 no 3161 0.0444839422080812 4592 1549252
SGTC_933 2914-0560 114 µM -1.70153520529102 0.0586238334625472 no 3162 0.044421266421197 4599 463887
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.71156428428233 0.0575681770588591 no 3163 0.0434884974818559 4591 688667
SGTC_3155 9099265 49.47 µM -1.71330656592741 0.0573863190875066 no 3164 0.0433280775434266 4575 25236499
SGTC_2060 5238662 140 µM -1.71639193144698 0.0570653803657198 no 3165 0.0430451661713083 4564 790130
SGTC_1971 st069429 63.5 µM -1.7175141758229 0.0569489959303103 no 3166 0.0429426332899332 4601 1246522 YGL099W LSG1
SGTC_2807 7945238 51.95 µM -1.7204926992807 0.0566410088458042 no 3167 0.0426714598128161 4573 17148797
SGTC_11 0438-0307 1.3 µM -1.72060533503121 0.0566293878169199 no 3168 0.042661232353704 4592 4011476
SGTC_1362 1611-0397 101 µM -1.72100776409942 0.0565878831307829 no 3169 0.0426247075076508 4597 27816
SGTC_576 1073-0113 22.7 µM -1.72597576685334 0.0560774781534596 no 3170 0.0421758862411925 4651 5439563
SGTC_1471 k673-0312 37 µM -1.72713643748354 0.0559587574118157 no 3171 0.0420715814979851 4595 24099884
SGTC_694 1315-0438 43.2 µM -1.72729052849521 0.0559430109262033 no 3172 0.0420577496788344 4630 6793154
SGTC_2006 4011487 200 µM -1.73083744455647 0.0555815186080068 no 3173 0.0417403806693057 4544 45595294
SGTC_2390 9097792 176.6 µM -1.73729000179109 0.0549286216602656 no 3174 0.0411679977239868 4617 4497149
SGTC_547 1120-0019 610 nM -1.7393916327863 0.0547172832090876 no 3175 0.0409829495063476 4577 3676939
SGTC_2262 9014885 67.46 µM -1.7432331958278 0.0543326404300328 no 3176 0.0406464445563956 4657 6457424
SGTC_549 1661-1316 519 µM -1.74356302129181 0.0542997160815182 no 3177 0.0406176580539793 4629 2857282
SGTC_1276 0871-0068 94.2 µM -1.7444891159655 0.0542073544052958 no 3178 0.0405369188267283 4616 3414906
SGTC_357 1325-0123 420 µM -1.74597712731773 0.0540592118087103 no 3179 0.0404074631994853 4597 1098503
SGTC_2915 7971052 15.16 µM -1.74616037425274 0.0540409903964976 no 3180 0.0403915441250008 4572 5741558
SGTC_1446 4239-0190 62 µM -1.7491559518081 0.053743809788125 no 3181 0.0401320328788852 4622 1340085
SGTC_1886 st057356 49.9 µM -1.75038174062017 0.0536225774309475 no 3182 0.0400262323062067 4593 24207747
SGTC_1750 st081859 2.357 µM -1.75159400520508 0.0535028957986087 no 3183 0.0399218220641175 4523 5291695
SGTC_2831 7999036 19.48 µM -1.75528513266093 0.0531397896987981 no 3184 0.0396052741183619 4570 2988270
SGTC_1416 3966-0321 25.3 µM -1.7570428876288 0.0529675627486086 no 3185 0.0394552496494048 4669 582530 YLR208W SEC13
SGTC_1201 1889-3372 45.9 µM -1.76354952461502 0.0523338840655651 no 3186 0.0389039261159323 4518 5392199
SGTC_580 1123-0028 41 µM -1.76750920592915 0.0519512081558845 no 3187 0.0385714943230576 4662 1677248 YPR107C YTH1
SGTC_2200 6600604 21.907 µM -1.77580426143074 0.0511567569954127 no 3188 0.0378825925466722 4645 2904777
SGTC_644 1498-1197 63.3 µM -1.77856517149145 0.0508944881192555 no 3189 0.0376555391924233 4652 6741615
SGTC_2707 st078556 66.6 µM -1.77991609237685 0.0507665498429403 no 3190 0.0375448468354614 4542 17250899
SGTC_1213 1315-0166 115 µM -1.78165231198979 0.0506024982715358 no 3191 0.0374029740265245 4600 768401
SGTC_148 3253-0744 288.01 µM -1.78796112512425 0.0500099445693343 no 3192 0.0368911399900527 4514 6893655
SGTC_2755 lomerizine 42.69 µM -1.80907261737308 0.0480671988769151 no 3193 0.0352198612519055 4569 3949 A calcium channel blocker.
SGTC_1252 0493-0875 34.8 µM -1.81124548423664 0.047870720824674 no 3194 0.0350514301576562 4598 3960963
SGTC_2859 9028643 45.46 µM -1.81412611700452 0.0476112359480125 no 3195 0.0348291557672894 4491 17151580
SGTC_86 0417-1630 471.922 µM -1.8260275092887 0.0465510893826102 no 3196 0.0339230591122164 4650 3634867
SGTC_1014 4130-3005 69.3 µM -1.827468011723 0.046424068383625 no 3197 0.033814715776074 4634 743608
SGTC_1677 st019204 53.9 µM -1.8322507981297 0.0460043249196288 no 3198 0.0334570318994467 4632 3945625
SGTC_1691 st019933 84.6 µM -1.8328771304142 0.045949583685005 no 3199 0.0334104227342448 4632 6176082
SGTC_1343 1487-0095 224 µM -1.83345561167279 0.0458990711158976 no 3200 0.0333674219575887 4623 4560101 YGL055W OLE1
SGTC_1010 4112-3296 15.2 µM -1.85171104357257 0.0443278124406124 no 3201 0.0320336636683542 4651 704384
SGTC_671 0560-0003 407 µM -1.85371919459698 0.0441576482610744 no 3202 0.0318896720764045 4623 3238678
SGTC_973 1325-0077 65.9 µM -1.85659088337516 0.0439152260915439 no 3203 0.0316846909811606 4646 2835149
SGTC_1004 4084-0029 199 µM -1.86087130470922 0.0435558751588731 no 3204 0.0313811764684514 4648 716894 YLR208W SEC13
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.86098701535131 0.043546194035749 no 3205 0.0313730051897467 4640 689007
SGTC_1637 st007924 17.4 µM -1.86208171142476 0.0434546903830028 no 3206 0.0312957867301734 4572 683336
SGTC_2108 5365811 200 µM -1.86643343234851 0.0430924718009623 no 3207 0.0309903746542266 4654 780283
SGTC_321 4534-3890 65.3 µM -1.86966964150569 0.0428246880992349 no 3208 0.0307648538999373 4649 699746
SGTC_3199 9111318 49.47 µM -1.87287135807709 0.0425610836149853 no 3209 0.0305430755926406 4560 8548020
SGTC_2066 5222451 176 µM -1.89079060872471 0.0411098785213269 no 3210 0.0293261506582198 4599 2281147
SGTC_807 1315-0151 48 µM -1.89702975415088 0.0406141137850298 no 3211 0.0289120056077206 4652 4011080
SGTC_2602 kawain 100 µM -1.90079406287743 0.0403173549912071 no 3212 0.0286644960234945 4622 5369129
SGTC_1861 st057647 17.4 µM -1.90109202668327 0.0402939404611456 no 3213 0.0286449798941623 4663 688668
SGTC_3127 9126946 49.47 µM -1.91154170910724 0.039479746548496 no 3214 0.0279675010556455 4615 27243249
SGTC_1521 st012942 49.4 µM -1.91430224667605 0.0392669067854043 no 3215 0.0277907737717389 4594 24207259
SGTC_2099 5377090 177.372 µM -1.91475514601419 0.0392320771960714 no 3216 0.027761868577391 4657 2243829
SGTC_911 3456-4043 236 µM -1.9196244219741 0.0388591983886678 no 3217 0.0274526784744416 4638 914281
SGTC_2212 7123476 200 µM -1.92561758853622 0.0384042224130743 no 3218 0.0270760704475094 4710 1085715
SGTC_1802 st050112 57.9 µM -1.92776846926309 0.0382419992614025 no 3219 0.0269419656381748 4684 4662563
SGTC_670 4204-0025 119 µM -1.9288729843917 0.0381589122119845 no 3220 0.0268733162024741 4669 719039
SGTC_803 4488-1585 147 µM -1.93441210092922 0.0377444505022761 no 3221 0.0265312399066506 4672 747204
SGTC_430 0958-0115 16.4 µM -1.94244800867674 0.0371497067435204 no 3222 0.0260414440948895 4612 6833180
SGTC_1866 st057638 64 µM -1.9444379498964 0.0370036187492102 no 3223 0.0259213306106921 4687 688802
SGTC_66 0109-0187 42.4 µM -1.94467479040286 0.03698626283899 no 3224 0.0259070657576726 4504 759417
SGTC_3090 9117696 49.47 µM -1.95721964744807 0.0360764315935699 no 3225 0.0251608249062191 4663 7923821
SGTC_1948 st076329 66.6 µM -1.96648020009182 0.0354166249711239 no 3226 0.0246215836387533 4609 24208413
SGTC_280 3448-3607 3.04 µM -1.97005585327445 0.0351645252051585 no 3227 0.0244159848520508 4655 626179
SGTC_2597 laccaic acid a 100 µM -1.9711936842917 0.035084612431784 no 3228 0.0243508630271259 4627 5491415 A textile dye.
SGTC_266 formosanin C 406 nM -1.97228366912842 0.0350081998302447 no 3229 0.0242886164237892 4532 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1895 st058434 18.3 µM -1.98248133873357 0.0342998957813205 no 3230 0.0237126969804435 4679 5393175
SGTC_3233 9132340 49.47 µM -1.98301902398092 0.0342628788241915 no 3231 0.023682652297406 4693 17682950
SGTC_2391 6285546 200 µM -1.98779138922674 0.03393576224867 no 3232 0.0234173832296292 4687 846083
SGTC_3069 9117009 49.47 µM -1.9894324550444 0.0338238724230249 no 3233 0.0233267451609899 4692 41904981
SGTC_284 0988-0104 32.6 µM -1.9957534295696 0.0333957331976737 no 3234 0.0229803840974139 4658 4666532
SGTC_2024 5144227 134 µM -2.00119069791879 0.0330310294936522 no 3235 0.0226859215174711 4665 3475211
SGTC_540 1187-0821 17.3 µM -2.01539082158745 0.0320940135933282 no 3236 0.0219318576903579 4637 847520
SGTC_3299 9121982 43.1275 µM -2.02846611543172 0.0312507336164346 no 3237 0.0212563491085545 4681 17594604 YPL160W CDC60
SGTC_353 1988-1175 58.3 µM -2.05072304205698 0.0298574761581894 no 3238 0.0201469628600535 4548 2788357
SGTC_1086 cerivastatin 2.18 µM -2.0519513976706 0.0297821073651122 no 3239 0.0200871930235084 4705 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_67 0335-0847 266 µM -2.05487089221981 0.0296036077868166 no 3240 0.0199457382951851 4659 4552207 YOR254C SEC63
SGTC_767 0929-0023 86 µM -2.05825527401895 0.0293977969087122 no 3241 0.0197828175771925 4719 1204563
SGTC_1899 st063254 59.6 µM -2.05994704005185 0.0292953635126986 no 3242 0.0197018020104762 4680 3093813
SGTC_2295 7971645 200 µM -2.07094307522091 0.0286367746109771 no 3243 0.0191820580400633 4713 2978226 YKL099C UTP11
SGTC_839 0122-0028 230 µM -2.07437600231878 0.0284337050106618 no 3244 0.0190222021278323 4709 759448
SGTC_42 0133-0086 60.653 µM -2.07790208310477 0.0282263738363138 no 3245 0.0188591893167037 4613 162923 Model of phenazepam hydroxylation.
SGTC_352 k048-0007 5.11 µM -2.07929814987168 0.0281446345467087 no 3246 0.0187949775405027 4633 6811911
SGTC_619 1652-1634 108 µM -2.08599392412355 0.027755333453753 no 3247 0.0184895867180982 4672 5400454
SGTC_2061 5245884 80.95 µM -2.08608495256465 0.0277500720134623 no 3248 0.0184854642452219 4678 573863
SGTC_1804 st050076 49.1 µM -2.09773659866548 0.0270834357318235 no 3249 0.017964209976347 4712 3895976
SGTC_1954 st077032 68.9 µM -2.09843286689498 0.0270440263271116 no 3250 0.0179334622289602 4651 698907
SGTC_532 1548-0774 215 µM -2.10179729157867 0.0268542706235935 no 3251 0.0177855182533263 4731 5932993
SGTC_2611 pyromycin 23.93 µM -2.10198314905062 0.026843820625249 no 3252 0.0177773759726449 4656 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_383 2324-0395 7.37 µM -2.10219135553117 0.0268321180668241 no 3253 0.0177682583750564 4698 3146421
SGTC_730 1436-0052 41.2 µM -2.10822123809281 0.0264950430769142 no 3254 0.0175059285191757 4717 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_3157 9099274 49.47 µM -2.13931803818598 0.0248123969368527 no 3255 0.0162049598964743 4716 17217662
SGTC_478 N-arachidonylglycine 10 µM -2.14351020814246 0.0245925678909671 no 3256 0.016036076141609 4750 5283389
SGTC_939 1165-0479 45.3 µM -2.15367481802946 0.0240663333480463 no 3257 0.0156328411535288 4698 1377347
SGTC_1242 0402-0103 60.1 µM -2.16116102909655 0.0236848405973626 no 3258 0.015341451311215 4670 432868
SGTC_2958 9077254 16.72 µM -2.16401919743746 0.0235405376247135 no 3259 0.015231438043104 4702 16457351
SGTC_653 0203-0016 55.2 µM -2.16541813015243 0.0234701784337309 no 3260 0.015177839429664 4749 295302
SGTC_1140 3229-1848 2.98 µM -2.16992607790117 0.0232446541688073 no 3261 0.0150062232091535 4706 2849525
SGTC_994 3910-0338 138 µM -2.17728931110312 0.0228802093635686 no 3262 0.0147294940992914 4730 3479481
SGTC_61 0978-8327 98.565 µM -2.1809361590986 0.0227014978123423 no 3263 0.014594069381388 4678 6150059 YHR072W ERG7
SGTC_404 fumagillin 50 µM -2.18399788119094 0.0225523698418126 no 3264 0.0144812018771882 4723 12015870 A methionine aminopeptidase binder.
SGTC_937 3122-0005 46.7 µM -2.19188497607831 0.0221720113200317 no 3265 0.0141939065850689 4700 759535
SGTC_1415 3966-0071 78.1 µM -2.19623852748185 0.0219643881281439 no 3266 0.0140374375394223 4670 2893185
SGTC_3040 9091894 49.47 µM -2.19644504961854 0.0219545798963147 no 3267 0.0140300520997236 4672 25236966
SGTC_766 1391-0721 126 µM -2.20067886652799 0.0217543193229583 no 3268 0.0138793829764129 4734 1020919 YIL115C NUP159
SGTC_2994 9053520 71.4286 µM -2.21253328713788 0.0212017939754475 no 3269 0.0134649194168876 4710 4647384
SGTC_283 0987-0079 11.7 µM -2.21469995732 0.021102101035155 no 3270 0.0133903329005824 4738 411556
SGTC_1248 0469-0687 58.6 µM -2.21535705890873 0.0210719449340466 no 3271 0.0133677831383273 4691 4017482
SGTC_2387 9077560 195.08 µM -2.22237036100476 0.0207523514843071 no 3272 0.0131291433269207 4720 5303272
SGTC_3039 9090270 49.47 µM -2.22986711671335 0.0204152754422441 no 3273 0.0128781330094674 4721 17173750
SGTC_1475 4092-1048 11.7 µM -2.23092656097278 0.0203680159917236 no 3274 0.0128429970044253 4726 2881759
SGTC_2004 4023728 41.89 µM -2.23240904072091 0.0203020415483787 no 3275 0.0127939704187995 4691 360084 YDR527W RBA50
SGTC_285 1486-1325 46 µM -2.23698906742047 0.0200993609625595 no 3276 0.0126435272896898 4748 22310230
SGTC_3232 9132874 49.47 µM -2.23914208702411 0.0200046776369514 no 3277 0.0125733362909508 4723 3784940
SGTC_1518 st038567 90.8 µM -2.25711478625741 0.0192289554546765 no 3278 0.0120004515926561 4703 77966
SGTC_2600 tangeritin 87.95 µM -2.25855976337738 0.0191677143824286 no 3279 0.0119553915442162 4687 68077 A bioactive flavone.
SGTC_635 k038-0028 24.7 µM -2.27505851997242 0.0184801391532255 no 3280 0.0114512097728165 4744 4035102
SGTC_558 k064-0027 21.3 µM -2.28008820823513 0.0182747534118631 no 3281 0.0113012287229816 4728 5088526
SGTC_727 3032-0951 202 µM -2.28367567315164 0.0181294515195776 no 3282 0.0111952993893657 4760 3652836
SGTC_537 1334-0398 209 µM -2.28637465023767 0.0180207858951836 no 3283 0.0111161750226809 4748 5846986
SGTC_1106 tegaserod maleate 11.7 µM -2.28731923018461 0.0179828868358615 no 3284 0.0110885984254078 4745 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2983 9022671 12.99 µM -2.28868590565034 0.0179281724964199 no 3285 0.0110488042592211 4724 6405161
SGTC_3240 9133527 49.47 µM -2.289898008389 0.0178797652707233 no 3286 0.0110136148618889 4740 17617455
SGTC_2010 4012422 159 µM -2.29093641683612 0.0178383835014878 no 3287 0.0109835456846738 4697 952393
SGTC_648 0375-0473 33.3 µM -2.29269365566111 0.0177685416153197 no 3288 0.0109328240296397 4746 1713139
SGTC_4 0960-0234 25.671 µM -2.31339443036236 0.0169631932683624 no 3289 0.0103504815171917 4691 6821112
SGTC_1162 k048-0130 20.1 µM -2.31557390164943 0.016880247279488 no 3290 0.0102907725956223 4745 6797406
SGTC_2257 7960413 200 µM -2.31809471514709 0.0167847433428253 no 3291 0.0102220870374087 4759 2974689 YIL048W NEO1
SGTC_2960 9079389 5.97 µM -2.32159801455941 0.0166527845330164 no 3292 0.0101272954540773 4714 16457355
SGTC_2052 5265182 7.135 µM -2.33550216200982 0.016137774380713 no 3293 0.00975860154576408 4720 1239884
SGTC_2191 5911152 200 µM -2.34182370661975 0.01590817454163 no 3294 0.00959488842932878 4750 2875902
SGTC_72 0744-0168 198.391 µM -2.34559885607814 0.0157724004778263 no 3295 0.00949827013532654 4681 677577
SGTC_2999 9069765 71.4286 µM -2.34964984448437 0.0156278125059908 no 3296 0.00939553946752645 4700 2097066
SGTC_1142 3253-1408 9.78 µM -2.35026530620708 0.0156059452571829 no 3297 0.0093800170698859 4742 256655
SGTC_3024 9090631 49.47 µM -2.35562299412763 0.015416694181545 no 3298 0.00924583714686976 4754 25236383
SGTC_2084 5306078 60.6385 µM -2.35767044094834 0.0153448938060237 no 3299 0.00919500549498496 4721 679340
SGTC_2845 9003024 42.97 µM -2.36089150191711 0.0152325180951006 no 3300 0.009115531793551 4716 2990173
SGTC_418 lividomycin a 100 µM -2.36825822886196 0.0149781635045822 no 3301 0.0089360285131962 4752 72394 An antibiotic.
SGTC_3330 9141424 71.43 µM -2.39263238111818 0.0141624424496531 no 3302 0.00836399615102254 4749 27261020
SGTC_2971 9092186 9.93 µM -2.4032133875413 0.0138204238088425 no 3303 0.00812585052243575 4707 25236400
SGTC_1805 st050013 60.3 µM -2.40817355525745 0.0136625600784754 no 3304 0.00801627865383685 4715 4037144
SGTC_2252 omeprazole 400 µM -2.42220062635898 0.0132245246750826 no 3305 0.00771341547782621 4782 4594 A proton pump inhibitor.
SGTC_294 k038-0071 157 µM -2.43175786165805 0.0129330696421802 no 3306 0.00751287427574145 4771 24152826
SGTC_1141 3253-0389 52.6 µM -2.45191401391183 0.0123365533816235 no 3307 0.00710493067169861 4750 5402031
SGTC_1462 k081-0014 26.5 µM -2.47272183262046 0.0117459008652419 no 3308 0.00670442332199487 4274 3270634
SGTC_2199 6590217 200 µM -2.48047433392828 0.0115321987018878 no 3309 0.00656038547248467 4777 703109
SGTC_2651 TUB2.036 5 µM -2.48404319175269 0.0114349614457228 no 3310 0.00649500256900261 4655 15992207 YFL037W TUB2
SGTC_1932 st074806 40.9 µM -2.5233502313139 0.0104102503462459 no 3311 0.00581212821687211 4761 17251235
SGTC_650 1328-0195 38 µM -2.54618960814874 0.00985238342101761 no 3312 0.005445300801309 4761 2780821
SGTC_1020 4335-0961 93.3 µM -2.55648073368183 0.00960966833358396 no 3313 0.00528684631412741 4747 669075
SGTC_1638 st008370 60.6 µM -2.57518604572236 0.00918186473996611 no 3314 0.00500930905228885 4731 24207134
SGTC_50 0929-0078 56.389 µM -2.59455669470362 0.00875650710274331 no 3315 0.00473564957486631 4706 1377751
SGTC_2008 4012253 172 µM -2.59559368748975 0.00873423118886257 no 3316 0.00472138278639294 4751 603940
SGTC_2114 5491910 81.25 µM -2.6164381533013 0.00829688333147454 no 3317 0.00444262295777969 4770 2849228
SGTC_1351 1496-0003 46.5 µM -2.64022234863809 0.00782145065430567 no 3318 0.00414258249589807 4782 3891978
SGTC_634 1611-4317 11.2 µM -2.68037513574589 0.00707305075070479 no 3319 0.00367698473828764 4790 2843522
SGTC_2985 9022375 71.43 µM -2.68470162252726 0.0069963090969819 no 3320 0.00362972912974155 4752 4939335
SGTC_144 4161-2749 112.381 µM -2.68652063634638 0.00696426417308694 no 3321 0.00361002440326551 4780 797501 YMR168C CEP3
SGTC_1574 spiramycin 23.7 µM -2.6970747171613 0.00678088114126361 no 3322 0.00349757864470763 4758 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_865 0488-0499 301 µM -2.71343381279974 0.00650505969023736 no 3323 0.00332949345525989 4753 9634651
SGTC_2447 5741742 33.78 µM -2.71572662647277 0.00646720556080111 no 3324 0.00330652492572344 4782 1776504
SGTC_468 gf-109203x 121 µM -2.7247332552918 0.0063203866051112 no 3325 0.00321767277573369 4797 2396 A protein kinase C inhibitor.
SGTC_639 0833-0042 114 µM -2.72644023801525 0.0062928957232591 no 3326 0.00320107724722252 4783 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_435 c-PAF 6.7 µM -2.72986844600923 0.00623800419584581 no 3327 0.00316798018520079 4725 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_487 nimodipine 119 µM -2.75012532309128 0.00592222833732897 no 3328 0.00297862379805226 4790 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2944 9067346 25.62 µM -2.76182829218966 0.00574632902965823 no 3329 0.00287393492062497 4725 6473075
SGTC_1340 1486-1359 257 µM -2.76649345471845 0.00567751297399646 no 3330 0.00283313611634317 4766 4309068
SGTC_2946 9065502 71.43 µM -2.77230850730602 0.0055927598326138 no 3331 0.00278301286117499 4753 16489101
SGTC_902 1120-0002 2.07 µM -2.83260154054523 0.00477804944610694 no 3332 0.00230854497378153 4783 3280475
SGTC_2967 9089538 49.85 µM -2.83396343511516 0.00476093759479424 no 3333 0.00229872960640238 4760 728216
SGTC_1705 st027868 56.3335 µM -2.86479049754985 0.00438794428112047 no 3334 0.00208642607446276 4779 292948
SGTC_3231 9132313 49.47 µM -2.95519405906329 0.00344003622604924 no 3335 0.00156236218488044 4795 4905967
SGTC_1789 tunicamycin 25 nM -3.03785792845116 0.00273885428053386 no 3336 0.00119133128970569 4772 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1463 k081-0032 34.1 µM -3.11526068481557 0.00220210593061371 no 3337 0.000918912053878667 4475 977755
SGTC_1099 5-nonyloxytryptamine 2.85 µM -3.12002330263612 0.00217242568477619 no 3338 0.000904183667680421 4798 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_58 0957-0393 9 µM -3.13142829289301 0.00210281928555661 no 3339 0.00086979130938739 4482 6997992
SGTC_2582 agaric acid 100 µM -3.16270611599374 0.00192218422813044 no 3340 0.000781550197396032 4621 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_945 3381-0768 11.3 µM -3.17662948406474 0.00184640558953186 no 3341 0.00074498629709835 4791 1126236 YIL048W NEO1
SGTC_154 3389-1638 511.116 µM -3.18077426082386 0.00182437790511286 no 3342 0.000734410169004072 4790 5238686
SGTC_2015 5119600 184 µM -3.21102224842792 0.00167072214098602 no 3343 0.000661318471281643 4783 2828786
SGTC_3338 9144300 39.5675 µM -3.27507130186133 0.00138355176064185 no 3344 0.000528176540433875 4796 4901274
SGTC_546 peri-Naphthalide 147 µM -3.28147849906738 0.00135745934233183 no 3345 0.000516321985473054 4795 223824 A penicillin ester.
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -3.29760390573415 0.00129376836278118 no 3346 0.000487567937116546 4778 6708739 YPR165W RHO1
SGTC_3162 9099653 49.47 µM -3.35391858085945 0.00109218062162678 no 3347 0.000398379016787879 4802 25237511
SGTC_2773 thioridazine 9.09 µM -3.43448234191402 0.000853540840831342 yes 3348 0.000296843375427796 4797 5452 An antipsychotic.
SGTC_1738 st035555 74 µM -3.58064172281455 0.000538835163256977 yes 3349 0.000171375685975411 4801 5331140
SGTC_2329 6138490 200 µM -3.58969097887099 0.000523423291335388 yes 3350 0.000165535101585102 4787 720019
SGTC_1050 3232-1156 69.3 µM -3.63175809893891 0.000456989885285117 yes 3351 0.000140748464714325 4800 700529
SGTC_453 enantio-paf c16 10 µM -3.72940093397268 0.000331741920078948 yes 3352 9.59677736547792e-05 4536 13871343 A lipid and platelet activating factor
SGTC_2595 hexamethylquercetagetin 100 µM -3.76878575985189 0.000290928280830419 yes 3353 8.20218047391128e-05 4796 386331
SGTC_489 paxilline 115 µM -3.78913938272063 0.000271717357592575 yes 3354 7.55850413415968e-05 4806 105008 A toxic potassium channel blocker.
SGTC_2027 5150920 200 µM -4.26690565177711 4.98401928257453e-05 yes 3355 9.91014657252913e-06 4808 786715
SGTC_631 k072-0230 41.5 µM -4.8183530859869 5.63807968894614e-06 yes 3356 7.23740245938502e-07 4809 5773147