SGTCid condition conc unit YDL026W|YDL026W.score YDL026W|YDL026W.strain.pval YDL026W|YDL026W.strain.significant YDL026W|YDL026W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_69 0096-0274 206.684 µM 8.21782190758394 1.15005688111325e-15 yes 1 1.03616200324037e-16 3 6741392 SGTC_1346 1488-2224 62.4 µM 5.83412719110898 9.43185423844854e-09 yes 2 2.7036431499192e-09 7 3722427 SGTC_2592 piperlongumine 83.33 µM 5.79177023854382 1.19426386498796e-08 yes 3 3.48241903518702e-09 8 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2918 7977171 22.06 µM 5.72838328802994 1.69502249419615e-08 yes 4 5.06961367080943e-09 5 2236483 SGTC_2925 9010536 32.5 µM 4.93401304002293 1.00263078091492e-06 yes 5 4.02785289826447e-07 25 2994177 SGTC_2999 9069765 71.4286 µM 4.79260271259381 1.95286458471293e-06 yes 6 8.2315718585142e-07 9 2097066 SGTC_196 k015-0023 18.111 µM 4.54973256395178 5.88506178260499e-06 yes 7 2.68570695078938e-06 13 5211998 SGTC_143 4032-1194 15.74 µM 4.42183522997635 1.02995729294011e-05 yes 8 4.89330388345822e-06 44 1806963 SGTC_1926 methyl fluorone black 53.6 µM 4.39074272301421 1.17747383429642e-05 yes 9 5.64820687443003e-06 48 72721 Reacts with homocysteine. SGTC_1207 2099-0101 141 µM 4.27858719839343 1.89465451990018e-05 yes 10 9.40416537186303e-06 10 5837381 SGTC_2638 epoxomicin 18 µM 4.23664226890742 2.25702938891644e-05 yes 11 1.13443590814686e-05 25 9915668 A protesome inhibitor. SGTC_457 grayanotoxin iii 135 µM 4.21182904934073 2.50138333460544e-05 yes 12 1.26655610720703e-05 55 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1140 3229-1848 2.98 µM 4.15078490225249 3.21363141360993e-05 yes 13 1.65668522197303e-05 7 2849525 SGTC_2358 9037157 4 µM 4.03628512277242 5.09591249122926e-05 yes 14 2.71521077210268e-05 29 2388925 SGTC_3098 9119039 49.47 µM 3.76433557235376 0.000145398040736886 yes 15 8.34962535483145e-05 39 17161528 SGTC_453 enantio-paf c16 10 µM 3.68183124861212 0.000197283236594527 yes 16 0.000115782335644089 167 13871343 A lipid and platelet activating factor SGTC_1784 st039334 36.3 µM 3.67977054842673 0.000198777431748093 yes 17 0.000116721952731652 26 3496984 SGTC_122 0236-0016 402.397 µM 3.63283439031699 0.000235811346136372 yes 18 0.000140162472893709 45 6808838 SGTC_1379 2144-0755 36.5 µM 3.59756199333045 0.000267775145354068 yes 19 0.000160606975577015 33 5392327 SGTC_669 0108-0021 26.2 µM 3.55742757095698 0.000309035317091684 yes 20 0.000187252157284348 107 17201 SGTC_1590 st077108 57.8 µM 3.39810555989599 0.000538299299096732 yes 21 0.00033927116378704 13 5489485 SGTC_1345 1488-0192 31.4 µM 3.39217743288561 0.000549294754899097 yes 22 0.000346697611049163 28 658348 SGTC_272 doxorubicin 8.13 µM 3.35840227313757 0.000616004546235687 yes 23 0.000391972179069569 42 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_500 h-89 112 µM 3.35074348111737 0.000632137292969048 yes 24 0.000402974612644209 49 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2046 4110841 106 µM 3.3253545167427 0.000688448802586884 yes 25 0.000441530861358234 47 44119630 YMR134W ERG29 SGTC_1731 st035964 63 µM 3.28548289701966 0.0007862839716234 yes 26 0.00050903861465921 59 6739575 SGTC_2092 5303694 80.6725 µM 3.28202489562978 0.0007953457566936 yes 27 0.000515322525823325 63 1963699 SGTC_2675 theaflavin digallate 100 µM 3.27391107266647 0.00081698696889957 yes 28 0.000530349931368831 58 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_207 4185-0010 4.486 µM 3.25127366770985 0.000880262749449104 yes 29 0.000574446051542213 130 3761753 SGTC_1866 st057638 64 µM 3.22677646495092 0.000953790344358685 yes 30 0.000625966114383354 26 688802 SGTC_2640 pentamidine 10.38 µM 3.22255118429939 0.00096702857713386 yes 31 0.000635272316118153 59 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2476 5806916 10.51 µM 3.20118547059477 0.00103659013254597 no 32 0.00068431702607478 36 2870194 SGTC_1609 st001574 46.4 µM 3.19992487750423 0.00104083432838584 no 33 0.000687317058100169 37 3960012 SGTC_3306 9127676 59.7925 µM 3.18693635490109 0.00108550201600448 no 34 0.000718942057872833 52 41905287 SGTC_1230 0170-0365 3.77 µM 3.18678384686414 0.00108603677613717 no 35 0.000719321231947409 118 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_3308 9128332 17.569 µM 3.15266929347657 0.00121191146319621 no 36 0.000808924895549333 126 17332805 YDL196W YDL196W SGTC_418 lividomycin a 100 µM 3.14711055623974 0.00123364364155314 no 37 0.000824463008872952 41 72394 An antibiotic. SGTC_572 0960-0087 17.7 µM 3.1328956126853 0.00129084937776588 no 38 0.000865454947364713 67 6796365 SGTC_1462 k081-0014 26.5 µM 3.12744139930022 0.00131343547672295 no 39 0.000881674843110839 19 3270634 SGTC_2310 7668677 200 µM 3.12735285066925 0.00131380512181341 no 40 0.000881940461928198 78 2197143 SGTC_746 1095-0025 46.6 µM 3.09179021924513 0.00147018888528506 no 41 0.000994766975273572 46 6749286 SGTC_775 4577-0580 57.3 µM 3.08971306092205 0.00147982794568516 no 42 0.00100174974887397 32 2006902 SGTC_511 blebbistatin 171 µM 3.08705941112053 0.00149222610227603 no 43 0.00101073595236324 52 3476986 A myosin inhibitor. SGTC_3233 9132340 49.47 µM 3.08329588569158 0.00150997227076306 no 44 0.00102360747526417 54 17682950 SGTC_1897 st060201 15 µM 3.07194231317453 0.00156468049952804 no 45 0.00106335410454909 49 611878 SGTC_976 1348-1067 47.6 µM 3.06410537219318 0.00160349119842357 no 46 0.00109160998806913 74 5310671 YGL099W LSG1 SGTC_2746 daunorubicin 9.88 µM 3.03825613907296 0.00173780413125175 no 47 0.00118975803376922 15 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1942 st076330 65.2 µM 2.99577584984495 0.00198091836020667 no 48 0.00136873789039953 72 24208414 SGTC_2919 7978188 46.38 µM 2.99378465880301 0.00199303744343831 no 49 0.00137770171196099 67 2980291 SGTC_70 0141-0289 43.283 µM 2.99188099470927 0.00200468671320794 no 50 0.00138632161884476 284 352408 SGTC_3271 9137798 49.47 µM 2.98438459362378 0.0020511635719715 no 51 0.00142074684326119 32 6498326 SGTC_2934 9036370 36.88 µM 2.96534454494033 0.00217363782439376 no 52 0.00151172052898303 83 6462800 SGTC_2461 5755302 26.15 µM 2.8226607735862 0.0033236935616702 no 53 0.00238134677853247 102 2788904 SGTC_917 harmaline 728.087 nM 2.80596892847865 0.00348899824668841 no 54 0.00250827647032155 89 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_3350 9150499 3.57 µM 2.7945037391014 0.00360678134024142 no 55 0.00259897198352756 127 4910996 YPR165W RHO1 SGTC_702 1488-0190 94 µM 2.77787227900751 0.00378398375957306 no 56 0.00273580604532726 60 949357 SGTC_926 2268-1401 59.4 µM 2.75681907385363 0.00401947279393412 no 57 0.00291833183402307 88 2931578 SGTC_1787 fluconazole 80 µM 2.74722761950152 0.00413104350847606 no 58 0.00300507036682819 125 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1794 st048918 76.9 µM 2.74080845074299 0.00420725302602807 no 59 0.00306441128574765 50 672303 SGTC_3040 9091894 49.47 µM 2.72928043592635 0.0043472781284539 no 60 0.00317363505644507 65 25236966 SGTC_3188 9110789 49.47 µM 2.72677582531716 0.00437824562819171 no 61 0.00319782369316601 91 849217 SGTC_120 rhodamine 6G 52.259 µM 2.71300436928873 0.00455206630467323 no 62 0.00333381137095472 122 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1803 st050068 52.4 µM 2.70446183175822 0.00466295990519483 no 63 0.00342075644689107 307 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_338 4055-0136 114 µM 2.64301188888272 0.00553424811585138 no 64 0.00410860749527439 83 2900563 SGTC_649 1123-0311 367 µM 2.63194645632925 0.00570567510353761 no 65 0.00424486206948815 160 693629 YIL048W NEO1 SGTC_3303 9125618 40.5795 µM 2.6312304476456 0.00571692825231086 no 66 0.00425381629010057 160 22695467 SGTC_140 0062-0056 502.533 µM 2.62807337778417 0.00576678161095774 no 67 0.00429349953078839 101 3758964 SGTC_579 4491-1009 110 µM 2.62057160248466 0.00588679292807888 no 68 0.00438912469248274 121 1271041 SGTC_139 0099-0334 718.624 µM 2.6164737422059 0.00595328050670126 no 69 0.00444215986389713 122 97690 SGTC_2417 cerulenin 830 nM 2.59079636121407 0.00638525773749279 no 70 0.00478770671558104 100 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_803 4488-1585 147 µM 2.56809719425299 0.00678999559521097 no 71 0.00511292399174066 86 747204 SGTC_2784 7567673 72.73 µM 2.56232172354708 0.00689652542528269 no 72 0.00519874763045516 133 3471247 SGTC_2013 4024628 200 µM 2.54451370969503 0.00723434697506259 no 73 0.0054715007974874 142 5230760 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 2.54203746002531 0.0072824593949848 no 74 0.00551041806232219 115 6708760 SGTC_1315 1237-0019 3.69 µM 2.54011018593336 0.00732010047169092 no 75 0.00554087750713072 93 825140 SGTC_1309 pyrazolanthrone 13.4 µM 2.53971523680339 0.00732783525826768 no 76 0.00554713788273036 100 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2771 fluoxetine 41.05 µM 2.49966776822336 0.00815051675233053 no 77 0.00621549120317549 104 3386 A selective serotonin reuptake inhibitor. SGTC_1674 st016616 23.6 µM 2.49044325033422 0.00835113529056694 no 78 0.00637919344874963 133 625830 SGTC_2045 5106652 78.05 µM 2.47814287956312 0.00862538705814452 no 79 0.00660341233333738 89 673349 SGTC_155 k072-0202 43.6 µM 2.47695439693331 0.00865229964250926 no 80 0.00662544157667303 92 5857737 SGTC_1161 k007-0610 110 µM 2.46953569936495 0.00882196283291705 no 81 0.00676442594347388 259 5843850 SGTC_2764 methyldopa 94.69 µM 2.46701325202742 0.00888031103487651 no 82 0.00681226575873744 125 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1529 apigenin 74 µM 2.46221658736755 0.00899219902308846 no 83 0.00690406270876855 153 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1734 st037168 69.4 µM 2.45936174085849 0.00905937632470465 no 84 0.0069592148122997 137 708907 SGTC_2711 st079103 59.1 µM 2.45672337441974 0.00912184999270409 no 85 0.00701053024570351 84 54693780 SGTC_1845 st056753 3.01 µM 2.45537567455548 0.00915390737700431 no 86 0.00703687125011949 140 5375839 SGTC_2291 7917025 104.35 µM 2.44801275802292 0.00933079425442556 no 87 0.00718232845540029 178 2964612 SGTC_1356 1502-0781 85.8 µM 2.42601720695687 0.0098771458810362 no 88 0.0076327732383082 121 567702 SGTC_818 4072-2707 53.5 µM 2.39584986620016 0.0106718036306424 no 89 0.00829094035108263 106 882871 SGTC_1980 st071811 45.7 µM 2.39399297192339 0.0107224871728634 no 90 0.00833303406737669 120 4974850 SGTC_1657 st012939 43.4 µM 2.39341749234257 0.0107382372536418 no 91 0.00834611758066079 98 24207257 SGTC_1799 st045822 46.1415 µM 2.39060459373992 0.0108155125990052 no 92 0.00841032863425931 106 3674992 SGTC_3146 9095609 49.47 µM 2.38587744613336 0.01094646630599 no 93 0.00851921398691837 122 17173999 SGTC_147 4466-0538 29.23 µM 2.38553079957463 0.0109561233418659 no 94 0.00852724712388469 152 6742687 YHR072W ERG7 SGTC_3095 9117207 49.47 µM 2.38481806455658 0.0109760023261158 no 95 0.00854378482578511 82 17015229 SGTC_2011 4012611 177 µM 2.38438459480516 0.0109881076266667 no 96 0.00855385644781209 152 2049887 SGTC_674 0498-0004 451 µM 2.3723370779834 0.0113292319615897 no 97 0.00883797833844948 139 4231473 SGTC_1962 st076595 64.5 µM 2.36669137386997 0.0114922317008938 no 98 0.00897394625673402 155 279619 SGTC_1292 0kpi-0043 232 µM 2.36294836115648 0.0116014174816872 no 99 0.00906509782891228 121 3333905 SGTC_813 k007-0158 173 µM 2.36136997729351 0.011647729135125 no 100 0.0091037777527988 172 6523916 SGTC_2477 5967686 25.23 µM 2.35719868227623 0.0117708931902569 no 101 0.00920669603793217 133 776118 SGTC_749 1000-0129 128 µM 2.349883698202 0.0119896096511127 no 102 0.0093896388599846 143 708470 SGTC_75 0159-0059 199.013 µM 2.348979686427 0.0120168825848693 no 103 0.00941246689457709 136 5377270 SGTC_1616 st002734 56.1 µM 2.3459136405483 0.0121097824705111 no 104 0.00949025234005684 169 4026101 SGTC_2543 pimpinellin 60.67 µM 2.34166797945989 0.0122394518147945 no 105 0.00959889237452995 137 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1329 1447-1697 50.6 µM 2.33667748384994 0.01239340638762 no 106 0.00972798008214577 145 2840515 SGTC_3330 9141424 71.43 µM 2.3270916519131 0.0126938347738136 no 107 0.00998019386828599 143 27261020 SGTC_2265 7929201 200 µM 2.3075424370068 0.0133261045434094 no 108 0.0105122996539917 159 1265108 SGTC_3270 9137563 49.47 µM 2.29722496940282 0.0136706319259199 no 109 0.0108029697131392 114 17015724 SGTC_1667 st014849 34.6 µM 2.29567900446127 0.0137229122254253 no 110 0.010847120889894 119 5348460 SGTC_1663 st014140 55.4 µM 2.28721397165642 0.0140122446720296 no 111 0.0110916684535061 161 4207120 SGTC_1810 st050138 53 µM 2.27653598685641 0.0143847026049427 no 112 0.0114069746276305 108 3444541 SGTC_578 3460-0051 92 µM 2.27375650782951 0.0144830403954609 no 113 0.0114903152735563 157 2876744 SGTC_1197 1601-0112 267 µM 2.26797486110452 0.0146894498467461 no 114 0.0116653694664418 177 7350313 SGTC_2837 9008476 45.46 µM 2.26618649503775 0.0147538062797336 no 115 0.0117199835771976 188 2992805 SGTC_2184 6075246 200 µM 2.25937968510862 0.0150009802698062 no 116 0.0119298884863781 143 2267320 SGTC_415 dibenzyl ketone 100 µM 2.25370313647234 0.01520982516457 no 117 0.0121074249619661 133 7593 SGTC_565 1418-0001 44.5 µM 2.24457147289546 0.01555102703609 no 118 0.0123978279079648 187 2862145 SGTC_2639 lactacystin 53 µM 2.24304258479048 0.0156087907887236 no 119 0.0124470342682796 173 3870 A proteasome inhibitor. SGTC_1994 st072947 40.9 µM 2.23766308328164 0.0158135025600326 no 120 0.012621517194895 156 5286565 YDL195W SEC31 SGTC_1917 st066507 28.5 µM 2.23626421127681 0.0158671109987701 no 121 0.0126672346462917 207 3156428 SGTC_3157 9099274 49.47 µM 2.23386364527111 0.015959470167974 no 122 0.0127460231322316 125 17217662 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 2.22946284398978 0.01612998339503 no 123 0.0128915624350725 105 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1966 st070145 16.1 µM 2.21160457703001 0.0168380310742434 no 124 0.013496999448524 160 3748532 SGTC_2345 9052315 157.45 µM 2.21079739159191 0.016870652782032 no 125 0.0135249352788157 178 6469265 SGTC_1171 0368-0077 21.4 µM 2.20222631991722 0.0172203920614813 no 126 0.0138246628833224 137 3239779 SGTC_2411 st077133 39.94 µM 2.20110466628596 0.0172666158930958 no 127 0.0138643075143036 217 1403142 YNL221C POP1 SGTC_3049 9092223 49.47 µM 2.19569398198461 0.0174910842029946 no 128 0.0140569271028757 155 8623917 SGTC_316 k060-0003 58.6 µM 2.19299021494646 0.0176041834644691 no 129 0.0141540420486822 155 6152314 SGTC_3164 9100705 49.47 µM 2.18936387393526 0.0177568537763429 no 130 0.0142852016041301 105 17174235 SGTC_2376 9072922 81.32 µM 2.16193922555436 0.0189484278344845 no 131 0.0153114304926921 211 17087968 SGTC_1625 st003711 30.1 µM 2.15254824685295 0.0193717910604413 no 132 0.015677099809396 191 24207034 YER133W GLC7 SGTC_642 0335-0876 158 µM 2.15237204887263 0.0193798105982438 no 133 0.0156840316638712 201 6812350 SGTC_2654 protoveratrine a 100 µM 2.15167673328702 0.0194114849748583 no 134 0.0157114119391154 148 5702278 A heart drug and vasodilator. SGTC_1640 st009078 66.4 µM 2.14888212218237 0.0195392345603775 no 135 0.0158218726691579 141 690618 SGTC_3249 9135183 49.47 µM 2.14078227568404 0.0199135423688023 no 136 0.01614579997229 182 4902779 SGTC_3195 9113082 49.47 µM 2.1378073055191 0.0200525402234507 no 137 0.0162661929220699 137 17018038 SGTC_2741 miltefosine 3.04 µM 2.13595208534397 0.0201396365794749 no 138 0.0163416597521214 141 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_788 1182-0090 188 µM 2.12745588200907 0.0205426145725362 no 139 0.0166911116307274 288 5715185 SGTC_2790 5423970 71.43 µM 2.12207060746973 0.0208015610772164 no 140 0.0169159046043086 250 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2749 bexarotene 57.39 µM 2.12177089514815 0.0208160533200815 no 141 0.0169284909270666 219 82146 An retinoic acid receptor inhibitor. SGTC_2017 5132927 60.65 µM 2.11877503203762 0.0209613851725924 no 142 0.0170547418914484 208 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_3129 9127257 49.47 µM 2.11175434305741 0.0213053321467228 no 143 0.0173537626179979 183 837894 SGTC_72 0744-0168 198.391 µM 2.10708000401378 0.0215369671080718 no 144 0.0175553226478668 192 677577 SGTC_643 k048-0106 28.4 µM 2.10288080910062 0.0217468679372452 no 145 0.017738094895652 162 6763920 SGTC_3199 9111318 49.47 µM 2.09459165742049 0.0221662842348513 no 146 0.0181036537308643 200 8548020 SGTC_2810 7959871 45.46 µM 2.08963895524179 0.0224201249023615 no 147 0.0183251222142169 254 2974535 SGTC_1371 2421-0008 32.7 µM 2.08861346736317 0.0224729894346581 no 148 0.0183712659496579 245 2827552 SGTC_1678 st019265 80.2 µM 2.08648209606879 0.0225831992664649 no 149 0.0184674876669464 225 5367020 SGTC_2010 4012422 159 µM 2.08062657188164 0.0228883270862349 no 150 0.0187340498927258 208 952393 SGTC_212 3807-4682 38.772 µM 2.06761520474888 0.0235787914962163 no 151 0.0193381105857959 315 3125501 YBL034C STU1 SGTC_3244 9134489 49.47 µM 2.06005783860649 0.0239878165658731 no 152 0.0196965059132712 197 16584271 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 2.056041754381 0.0242075932839429 no 153 0.0198892458481264 191 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_426 0988-0037 14.6 µM 2.04242560098759 0.024965351143704 no 154 0.0205546662105871 254 5383008 SGTC_2086 5274770 176.623 µM 2.03171873676243 0.025575081723892 no 155 0.0210910689892884 217 689278 SGTC_1658 st012944 20 µM 2.03061200974637 0.0256388122763057 no 156 0.02114718423549 240 24207260 SGTC_1725 st036284 20.55 µM 2.02294460326419 0.0260839984353725 no 157 0.0215394296208226 246 707914 SGTC_2301 7769476 200 µM 2.01217714069846 0.0267200794346552 no 158 0.0221006336366565 191 977820 SGTC_2016 5121758 140 µM 2.00596466422161 0.0270929351865244 no 159 0.0224300090874862 283 2795203 SGTC_2371 9071574 200 µM 1.99811749147292 0.0275700968228083 no 160 0.0228519619184349 168 45596039 SGTC_1959 st077091 55.8 µM 1.99347772388508 0.0278555075466887 no 161 0.0231045802180666 264 821356 YKL052C ASK1 SGTC_26 0302-0163 425.158 µM 1.9702809026252 0.0293195961682314 no 162 0.0244030929486763 185 3100915 SGTC_2894 9048625 32.47 µM 1.96935956916941 0.0293790421125142 no 163 0.0244559075512791 200 4092861 SGTC_264 promethazine 12.5 mM 1.96053419709575 0.0299535561715002 no 164 0.0249666925048138 343 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_3111 9122088 49.47 µM 1.95791518796111 0.0301258304254932 no 165 0.0251199827133357 134 16876704 SGTC_884 0851-0618 334 µM 1.95444312574139 0.0303554826866205 no 166 0.0253244173779121 246 9642473 SGTC_2021 4019055 173 µM 1.95189748774524 0.0305247786800604 no 167 0.0254751883112054 415 44827708 YER133W GLC7 SGTC_2084 5306078 60.6385 µM 1.94782780199981 0.030797054594617 no 168 0.0257177854728037 237 679340 SGTC_3333 9141820 12.094 µM 1.94306725351985 0.0311180999515307 no 169 0.026004016485718 192 1939433 SGTC_1916 st067606 49.2 µM 1.93409387683827 0.0317307813408053 no 170 0.0265507933223835 299 19590279 SGTC_230 MPP+ 141.667 µM 1.93372458071639 0.0317562080554831 no 171 0.0265734999727742 228 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1712 st032288 53.4 µM 1.93213739508405 0.0318656804155463 no 172 0.0266712749156398 463 2883011 SGTC_2329 6138490 200 µM 1.92761559093855 0.0321792712844401 no 173 0.0269514790781073 232 720019 SGTC_2555 cholic acid 100 µM 1.92376316789502 0.0324484457002559 no 174 0.0271921380651251 215 6708657 Influences liver metabolism. SGTC_688 0527-0193 473 µM 1.92273867937374 0.0325203400623132 no 175 0.0272564383004218 198 4007154 SGTC_1519 esterone 74 µM 1.92116030925814 0.0326313606617921 no 176 0.0273557501443612 247 698 A steroid. SGTC_2629 bisabolol 100 µM 1.91574421719216 0.0330147007739507 no 177 0.0276988306099423 269 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1251 0490-5699 265 µM 1.9146513284584 0.0330925014634659 no 178 0.0277684922653742 291 3883818 SGTC_3081 9117243 49.47 µM 1.90959135485384 0.0334546826056181 no 179 0.0280929245484706 225 45595589 SGTC_581 0958-0271 211 µM 1.90605881574297 0.0337094630551748 no 180 0.0283212876122691 333 4591145 SGTC_623 k072-0108 16.9 µM 1.90289600786437 0.0339389297411523 no 181 0.0285270580025659 249 5382803 SGTC_1199 1638-0010 4.46 µM 1.88956852645527 0.0349200143777605 no 182 0.029407844913868 278 3111136 SGTC_2758 dehydroepiandrosterone 69.35 µM 1.8891936521842 0.0349479433676808 no 183 0.0294329425013208 274 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_188 3229-0966 278.469 µM 1.88780431268001 0.0350516122733478 no 184 0.0295261130067483 303 5722370 SGTC_615 k087-0205 167 µM 1.8841130310747 0.0353282725568666 no 185 0.0297748439735212 230 9642773 SGTC_1048 3161-0300 24.5 µM 1.88188110721555 0.0354964215858538 no 186 0.0299260800783229 267 2165101 SGTC_134 0269-0018 6.916 µM 1.87587919444237 0.0359518516153733 no 187 0.0303359350816945 367 4378915 SGTC_3272 9137413 49.47 µM 1.87516750467073 0.036006171246967 no 188 0.0303848415520109 235 17614870 SGTC_1970 st070122 35.8 µM 1.87280346317721 0.0361870891032273 no 189 0.0305477647945692 280 102928 SGTC_2038 4100038 30.985 µM 1.87011738463067 0.0363935547269027 no 190 0.0307337594203322 287 3596803 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.86911839625365 0.0364705875785633 no 191 0.0308031720744163 272 6710655 SGTC_2285 7945142 200 µM 1.86888062209549 0.0364889421925697 no 192 0.0308197124301674 259 2970608 SGTC_911 3456-4043 236 µM 1.86741939969087 0.0366019050520851 no 193 0.0309215213869691 301 914281 SGTC_3294 9122953 26.2835 µM 1.86738042783969 0.0366049217651887 no 194 0.030924240511239 263 16459826 SGTC_2240 6690706 185.951 µM 1.86584320832164 0.0367240764059859 no 195 0.0310316525670692 223 805876 SGTC_1540 guanosine 70.6 µM 1.86555388543757 0.0367465381512626 no 196 0.0310519032648631 213 6802 Guanosine is a purine nucleoside SGTC_1263 0774-1208 64.8 µM 1.86095402965357 0.0371051623203578 no 197 0.0313753344014596 328 906585 SGTC_2531 methyl deoxycholate 70.07 µM 1.86048599517135 0.0371418120468192 no 198 0.0314083990264719 246 16667744 Haematoxylin. SGTC_3317 9138495 8.753 µM 1.85935823947838 0.0372302431747345 no 199 0.0314881884756751 277 17020139 SGTC_779 1360-0071 233 µM 1.84957403528316 0.0380046976452493 no 200 0.0321874839868415 277 7566 SGTC_1225 1216-0074 20.6 µM 1.84129281645366 0.0386704098260275 no 201 0.0327893299360325 259 4241466 SGTC_432 NS 1619 61.3 µM 1.83880860752898 0.0388719532613794 no 202 0.032971670891578 262 4552 A K+/calcium channel activator. SGTC_2121 5257820 149.641 µM 1.83436427989597 0.0392346546033051 no 203 0.0332999691140145 275 791256 SGTC_3185 9108267 49.47 µM 1.83269137810135 0.0393718915239402 no 204 0.0334242401049011 295 4910486 SGTC_1149 3909-7961 23.3 µM 1.83064313767321 0.0395404510165716 no 205 0.0335769127084358 276 735261 SGTC_1895 st058434 18.3 µM 1.8292404644654 0.0396562219547419 no 206 0.0336817965315211 269 5393175 SGTC_145 3737-0113 38.366 µM 1.82693253032355 0.039847309208602 no 207 0.033854957212993 380 6849351 SGTC_864 0469-0573 172 µM 1.81766409552901 0.040622248188783 no 208 0.0345577443129061 262 689425 SGTC_2545 solidagenone 89.61 µM 1.81752071215743 0.0406343319534284 no 209 0.034568709904777 134 6708572 An anti ulcer agent SGTC_1299 1079-1439 3.74 µM 1.81588126672324 0.0407727052059595 no 210 0.0346942937714407 258 323161 SGTC_1007 4101-0031 70 µM 1.80701404987558 0.0415277604574149 no 211 0.035380044290026 285 1146276 SGTC_1947 st076332 61.6 µM 1.80415423410623 0.0417736798491624 no 212 0.0356035658054972 227 24208416 SGTC_3177 9107506 49.47 µM 1.80386016081787 0.0417990343391164 no 213 0.0356266158916499 200 8897194 SGTC_2842 9000675 19.48 µM 1.8029374107315 0.0418786731662642 no 214 0.035699022414644 279 2989072 SGTC_2827 7993847 71.43 µM 1.79297558447266 0.0427462840659298 no 215 0.0364884140823824 233 2985692 SGTC_1044 1222-0021 1.78 µM 1.79212413300564 0.042821109104962 no 216 0.0365565419630453 316 4306703 SGTC_859 0439-0102 54.6 µM 1.7875727101787 0.04322288256843 no 217 0.0369224857942317 305 610143 SGTC_3291 9121177 71.43 µM 1.78509501791851 0.0434428754988666 no 218 0.0371229529769222 242 17015612 SGTC_2009 4012297 12.05 µM 1.78312973584875 0.0436180138906858 no 219 0.0372825934737567 319 45595307 SGTC_2581 avocatin a 64 µM 1.77433697817657 0.044408579944155 no 220 0.0380037137410272 335 6710728 A skin care supplement. SGTC_792 4534-1957 155 µM 1.76895996794345 0.0448976949594393 no 221 0.0384502777142573 274 1717904 SGTC_408 cantharidin 100 µM 1.76388428617126 0.0453633700639678 no 222 0.0388757314919332 335 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2967 9089538 49.85 µM 1.76067003686068 0.0456602692688543 no 223 0.0391471334846371 327 728216 SGTC_1308 1187-1617 41.4 µM 1.75551398305198 0.0461397931108431 no 224 0.0395857154977094 345 2882570 SGTC_1665 st014639 11.4 µM 1.75503110173703 0.0461849084603893 no 225 0.0396269939875298 341 981133 YIL048W NEO1 SGTC_1471 k673-0312 37 µM 1.74917903262813 0.0467344853098124 no 226 0.0401300386250165 274 24099884 SGTC_1256 0570-0116 285 µM 1.74407172455918 0.0472183968669702 no 227 0.0405732919014401 284 410638 SGTC_15 0266-0086 27.098 µM 1.73799003835397 0.0477998593661396 no 228 0.041106284535819 403 1712902 YIL048W NEO1 SGTC_1059 3448-6867 171 µM 1.72831522800113 0.0487366561316272 no 229 0.0419658621933945 310 3934407 SGTC_932 2857-0803 154 µM 1.72734652823671 0.0488312564905641 no 230 0.0420527238323591 319 674898 SGTC_1867 st057372 64 µM 1.72601245453571 0.048961778328759 no 231 0.0421725860688231 299 688837 SGTC_2829 7992743 58.44 µM 1.7230296146377 0.0492546189436772 no 232 0.0424415848667263 344 16462845 SGTC_3341 9147222 25.867 µM 1.71735626015039 0.0498154597905279 no 233 0.0429570491757042 295 1939759 SGTC_525 k781-2675 26.7 µM 1.71726310355713 0.0498247111410415 no 234 0.0429655551355103 359 3651118 YDL195W SEC31 SGTC_944 3370-0224 231 µM 1.71665843158155 0.0498847942382752 no 235 0.0430207997289684 312 4580514 SGTC_966 1300-0360 30.2 µM 1.70558669385184 0.0509951845823286 no 236 0.0440425292625334 328 70588 SGTC_2439 5492030 7.2 µM 1.70105036819702 0.0514557788056508 no 237 0.0444667647619395 296 5722370 SGTC_1854 st056233 32.9 µM 1.70080514455094 0.0514807714557744 no 238 0.0444897914637458 304 5393174 SGTC_2737 bleomycin 30.5 nM 1.69781859236056 0.0517859295854997 no 239 0.0447710028477149 385 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1696 st025591 34.7925 µM 1.69441843979143 0.0521350965807543 no 240 0.0450928989865982 349 2787147 SGTC_924 2046-0044 21.3 µM 1.69230030425638 0.0523535548428672 no 241 0.0452943649297719 330 3623589 SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.68533404160424 0.0530771642771176 no 242 0.0459620707215787 325 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1659 st012954 42.1 µM 1.68343691658839 0.0532755929140421 no 243 0.0461452708935305 290 24207262 SGTC_470 aa-861 153 µM 1.67870277895242 0.0537733219805897 no 244 0.0466049920476628 388 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1815 st051655 58.2 µM 1.67780870315215 0.0538677337845477 no 245 0.0466922248924554 276 5984156 SGTC_672 1441-0018 53.7 µM 1.67493393023394 0.0541721911545787 no 246 0.0469735977428535 309 251141 SGTC_2685 mycophenolic acid 18.85 µM 1.66673501720796 0.0550479939326562 no 247 0.0477835533438032 276 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3186 9110464 49.47 µM 1.66582959725284 0.0551453923794831 no 248 0.047873679645493 302 17018021 SGTC_1127 asiatic acid 681.4 nM 1.65745022972555 0.056053255921896 no 249 0.0487142416611319 354 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_541 4513-1321 94 µM 1.65529513687288 0.0562886451630632 no 250 0.0489323224662768 340 747515 SGTC_2840 9008771 71.43 µM 1.65445041661169 0.056381121739239 no 251 0.0490180149472876 271 2992978 SGTC_3245 9134821 49.47 µM 1.65343969121626 0.0564919292083787 no 252 0.0491207052804259 365 17014901 SGTC_3031 9088762 49.47 µM 1.65335338513918 0.0565013990312733 no 253 0.0491294819886942 350 205253 SGTC_2920 7982904 15.77 µM 1.64728160736077 0.0571707623969783 no 254 0.0497500882963523 311 6456808 SGTC_2980 9014342 25.29 µM 1.64571571519125 0.0573443975433573 no 255 0.0499111509975682 347 2996599 SGTC_1752 st044819 83.042 µM 1.6409070743719 0.0578802018380546 no 256 0.0504083531477698 353 441209 YML126C ERG13 SGTC_43 0570-0105 72.5 µM 1.63545073200995 0.0584929341568106 no 257 0.0509772973935844 500 1114046 YDL195W SEC31 SGTC_198 3454-2873 16.191 µM 1.6322005428673 0.0588603350380199 no 258 0.051318623234476 342 710957 SGTC_1364 1653-0028 37.6 µM 1.62989045219381 0.0591225664769673 no 259 0.051562325969579 367 5718652 SGTC_2053 5265679 138 µM 1.62976642303775 0.0591366716048664 no 260 0.0515754363952617 375 764595 SGTC_641 4092-0595 30 µM 1.62732057169672 0.0594153638705484 no 261 0.0518345155042681 355 786260 SGTC_2040 5100729 123 µM 1.62280229812265 0.0599329047762678 no 262 0.0523158371631614 373 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1602 st001878 87.6 µM 1.6221871404376 0.0600036396178798 no 263 0.0523816421464208 326 595405 YLR310C CDC25 SGTC_1952 st077036 64.1 µM 1.61804825450767 0.0604812567020415 no 264 0.0528260993992563 383 2937007 SGTC_3073 9114972 49.47 µM 1.61427383996364 0.060919403184746 no 265 0.0532340208855493 322 41905075 SGTC_1708 st033234 31.827 µM 1.6101442948012 0.0614016130126118 no 266 0.0536831795123195 373 674664 SGTC_1515 3460-0031 42.1 µM 1.60796482821178 0.0616573101500941 no 267 0.0539214410414933 304 2876596 SGTC_410 α-linolenic acid 100 µM 1.60696312274794 0.0617751097348808 no 268 0.0540312289727077 387 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3283 9109332 35.8195 µM 1.59585110756553 0.0630936855781981 no 269 0.0552610198216461 289 17027281 SGTC_3056 9094900 49.47 µM 1.59240726933718 0.0635067578085876 no 270 0.0556466119645005 385 25236784 SGTC_3305 9127027 53.8275 µM 1.5891064170451 0.0639046520051325 no 271 0.0560181846425138 368 41905295 SGTC_1539 benzyladenosine 56 µM 1.58706096512118 0.0641521878910523 no 272 0.0562494187988568 337 92208 A nucleotide analog. SGTC_2149 5554786 194.827 µM 1.58126058627768 0.0648581908149873 no 273 0.0569092337466593 425 745063 YPR165W RHO1 SGTC_347 4534-1311 26.2 µM 1.58088270076521 0.0649043942618933 no 274 0.0569524302252321 373 2862016 SGTC_2879 9041815 71.43 µM 1.57631165396823 0.0654653146948476 no 275 0.0574769985876428 241 4942971 SGTC_673 1082-0474 110 µM 1.575426681307 0.0655743442188212 no 276 0.05757899487883 473 3098046 SGTC_519 k048-0011 62.8 µM 1.56455890344856 0.0669247737375865 no 277 0.0588431856905849 393 6836379 SGTC_1607 st000305 50.6 µM 1.56306153385407 0.0671125110369977 no 278 0.0590190610652837 390 5457690 SGTC_609 0986-0026 86.3 µM 1.56305143737841 0.0671137782944121 no 279 0.0590202483572989 423 2848610 SGTC_376 3970-0862 59.1 µM 1.55857978675517 0.0676768578755512 no 280 0.0595479351237318 395 3135186 SGTC_1396 3511-0007 98.6 µM 1.55432841732108 0.0682155769322641 no 281 0.0600530491922528 342 X1396 SGTC_1849 st056239 19.2 µM 1.55331328782289 0.0683446988798369 no 282 0.0601741536395845 412 5393181 SGTC_577 r071-0003 38.6 µM 1.55323219235955 0.0683550221504717 no 283 0.0601838365293388 530 4568517 YMR134W ERG29 SGTC_360 0957-0399 1.01 µM 1.55182510067876 0.0685343333799608 no 284 0.0603520391283754 421 6752301 YPR165W RHO1 SGTC_1796 st049173 110.4 µM 1.54997996436681 0.0687700159466615 no 285 0.0605731624957117 314 94134 SGTC_806 3966-4455 5.86 µM 1.54919663048709 0.0688702613573912 no 286 0.0606672296159783 344 714982 SGTC_1332 1480-0653 17.5 µM 1.54840902240392 0.0689711672882382 no 287 0.0607619251665945 404 5749438 SGTC_2781 5567276 71.43 µM 1.54513491326815 0.0693918579700584 no 288 0.0611568168152138 409 2853274 SGTC_1802 st050112 57.9 µM 1.54154998726853 0.0698547492848304 no 289 0.0615914934379136 386 4662563 SGTC_1341 1486-1360 280 µM 1.54038652403176 0.070005487159803 no 290 0.0617330821338343 418 3976547 SGTC_3235 9132602 49.47 µM 1.54031539900363 0.0700147102035064 no 291 0.0617417459926382 436 4912240 SGTC_1027 k015-0025 8.67 µM 1.53906147700134 0.0701774644446089 no 292 0.0618946442680468 418 3598955 SGTC_1553 gossypol 38.6 µM 1.53582023195273 0.0705995137897403 no 293 0.0622912381074632 261 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2072 5231554 129 µM 1.53570949386811 0.0706139676178951 no 294 0.0623048227839082 371 789545 SGTC_166 k072-0058 166.424 µM 1.53365139653539 0.0708830100391392 no 295 0.0625577184158442 409 5846229 SGTC_2178 5812956 200 µM 1.5333151601962 0.0709270388852905 no 296 0.0625991105262926 372 5403383 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.52497945765082 0.0720252955753402 no 297 0.0636321107393537 413 115019 SGTC_47 0149-0135 24.25 µM 1.52218181871486 0.0723968015315654 no 298 0.0639817647136034 374 5239155 SGTC_352 k048-0007 5.11 µM 1.51478731625954 0.0733858054852879 no 299 0.0649131367832021 464 6811911 SGTC_1372 2752-0194 270 µM 1.51184646244202 0.0737820002462273 no 300 0.0652864632041751 394 823334 SGTC_169 k015-0017 16.025 µM 1.51153331267254 0.0738242842230045 no 301 0.0653263139008229 373 1840002 SGTC_1410 3909-8106 77.9 µM 1.51098885694862 0.0738978450615197 no 302 0.0653956449657689 373 1039210 SGTC_431 k089-0097 107 µM 1.51039298491588 0.0739784168856702 no 303 0.0654715887883432 499 5499420 SGTC_2598 perillyl alcohol 100 µM 1.50809095899321 0.0742903197871985 no 304 0.0657656244135409 427 10819 An apoptosis inducer. SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.50795121967656 0.0743092854332021 no 305 0.065783506086439 459 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1770 st043884 66.3 µM 1.50297131784795 0.0749875820947764 no 306 0.0664232202238082 416 670149 SGTC_2002 4023503 131 µM 1.50098488687393 0.0752594613323983 no 307 0.0666797352874199 526 4736863 YCR052W RSC6 SGTC_1158 4092-0494 91.8 µM 1.50008599173375 0.0753827381910591 no 308 0.0667960645445344 431 1148199 SGTC_2606 farnesol 9.78 µM 1.49922555958586 0.0755008842485211 no 309 0.0669075632012212 435 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_606 k015-0008 38.6 µM 1.49879284501736 0.0755603536453965 no 310 0.066963690679288 450 1970475 SGTC_3012 9080433 71.4286 µM 1.49714980793829 0.0757864867624089 no 311 0.0671771410275792 431 17688859 SGTC_3289 9119912 71.43 µM 1.49670085423339 0.0758483663640034 no 312 0.0672355569518821 421 17014829 SGTC_184 1494-0393 24.714 µM 1.49506926015797 0.0760735741599916 no 313 0.0674481837118887 445 3090647 SGTC_2969 9091408 28.7 µM 1.49326863691305 0.0763227034308784 no 314 0.0676834409018479 432 4286311 SGTC_724 3910-0327 137 µM 1.49216960652753 0.07647506706391 no 315 0.0678273439711091 445 2885483 SGTC_627 1391-0720 175 µM 1.49195367902525 0.0765050292641173 no 316 0.0678556444919853 414 997839 SGTC_1284 0929-0043 16 µM 1.49035216261897 0.0767275352214275 no 317 0.0680658318458483 453 1239883 SGTC_310 1273-0058 1.06 µM 1.48958040167309 0.0768349350264136 no 318 0.068167299146203 687 2734232 SGTC_2666 tannic acid 100 µM 1.48917972711043 0.0768907387573151 no 319 0.0682200238717102 463 16134267 A thiamine antagonist. SGTC_2407 paclitaxel 400 µM 1.48890625755031 0.0769288437678948 no 320 0.0682560277719354 461 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2564 betulinic acid 100 µM 1.484089094522 0.0776024187165008 no 321 0.0688926429878419 482 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_823 0417-1665 178 µM 1.48287125030802 0.0777734146611035 no 322 0.0690543105864714 433 3429856 SGTC_1738 st035555 74 µM 1.47733618488161 0.0785541915158708 no 323 0.0697927714787248 448 5331140 SGTC_11 0438-0307 1.3 µM 1.47563696127558 0.0787950721939409 no 324 0.0700206885936673 408 4011476 SGTC_2700 st077718 96.8 µM 1.47529794068297 0.078843198400013 no 325 0.0700662299217709 385 904970 SGTC_2740 felodipine 17.08 µM 1.47209869443032 0.0792984496810392 no 326 0.0704971140094935 341 3333 L-type calcium channel blocker SGTC_722 3534-0461 190 µM 1.46924810118255 0.0797057617972691 no 327 0.0708827539539347 449 658262 SGTC_2393 9031399 185.94 µM 1.46909337156692 0.0797279158161403 no 328 0.0709037326892363 440 1526623 YDL150W RPC53 SGTC_2951 9072950 58.06 µM 1.46859641882365 0.07979910047664 no 329 0.0709711433888458 464 16488155 SGTC_1469 k284-2957 126 µM 1.46618345078369 0.0801454231253561 no 330 0.0712991579354444 405 23884841 SGTC_515 4092-1064 102 µM 1.45313192776528 0.082038368335734 no 331 0.0730935639205419 507 717353 SGTC_943 3253-1379 105 µM 1.45044237446677 0.0824326037877015 no 332 0.0734675988672159 443 668464 SGTC_61 0978-8327 98.565 µM 1.45034277554327 0.0824472303658785 no 333 0.0734814780976985 465 6150059 YHR072W ERG7 SGTC_2448 5185112 27.17 µM 1.44794036602936 0.0828006279449345 no 334 0.0738168645856021 408 5718189 SGTC_3190 9110366 49.47 µM 1.44713655506008 0.0829191237024734 no 335 0.0739293408062866 367 17123768 SGTC_2748 diazoxide 86.69 µM 1.43961521958912 0.0840340879024957 no 336 0.0749881456389856 383 3019 A potassium channel activatior. SGTC_2427 5545055 42.75 µM 1.43364895468585 0.0849265048600087 no 337 0.0758362329012501 484 5372858 SGTC_1138 3761-0006 1.03 µM 1.43050430250119 0.0853997229233461 no 338 0.076286165924563 421 12061087 SGTC_2391 6285546 200 µM 1.42787156373611 0.0857974231744861 no 339 0.0766644148957335 489 846083 SGTC_1791 st048313 56.1 µM 1.42050311496328 0.0869178655154405 no 340 0.0777306311920358 407 1204976 SGTC_1872 amphotericin b 148 nM 1.41896442749855 0.0871532109998835 no 341 0.0779546935983724 471 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2211 7117706 200 µM 1.41781691616087 0.0873290348112478 no 342 0.078122112036405 426 822771 SGTC_2374 9071832 200 µM 1.41449447378164 0.0878395987261326 no 343 0.0786083844073265 422 17381698 SGTC_2207 7258803 200 µM 1.41273261302075 0.0881112478357308 no 344 0.0788671792801063 408 3666799 SGTC_1931 st074438 57.1 µM 1.41205060104403 0.0882165705149038 no 345 0.0789675312473753 439 2787313 SGTC_569 4130-2812 160 µM 1.41188228438991 0.0882425779811373 no 346 0.0789923124126904 348 743552 SGTC_1130 3454-2858 15.9 µM 1.41155416958362 0.0882932931043647 no 347 0.0790406375014286 492 715628 YIL048W NEO1 SGTC_2938 9059746 27.26 µM 1.41129167247282 0.0883338816552294 no 348 0.0790793144668522 430 6471769 SGTC_1476 4112-3294 3.34 µM 1.41069225277142 0.0884266189054068 no 349 0.0791676881607672 456 704369 SGTC_902 1120-0002 2.07 µM 1.40880775616702 0.0887186451416029 no 350 0.0794460105419052 508 3280475 SGTC_2157 5649910 96.377 µM 1.4014786926848 0.0898612046821711 no 351 0.0805354874168548 481 2858091 SGTC_2495 cafestol 54.53 µM 1.39559377474536 0.0907865182271436 no 352 0.0814184290724709 450 16667697 An anti-infammatory. SGTC_2692 st077426 47.7 µM 1.39228517084909 0.0913098409582563 no 353 0.0819180301154232 499 25238571 SGTC_704 1310-0270 142 µM 1.38953411510424 0.0917466763388271 no 354 0.0823351972601915 505 5718033 SGTC_1174 0739-0097 51.1 µM 1.38483313873968 0.0924967162429214 no 355 0.0830517476795369 508 728447 SGTC_3281 9140613 49.47 µM 1.38320387009786 0.0927577215083318 no 356 0.0833011817079078 431 16013766 SGTC_2115 tiliquinol 12.7705 µM 1.38273841792973 0.0928323858552212 no 357 0.0833725437582429 454 71208 A bioactive hydroxyquinoline. SGTC_1762 st045503 25.4615 µM 1.37213494441381 0.0945453728792533 no 358 0.0850107164410251 514 4645554 SGTC_2517 totarol 10 µM 1.3704792809743 0.0948149345561626 no 359 0.0852686693502759 447 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.36508231407789 0.0956975563632202 no 360 0.0861135900339813 522 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3340 9146634 11.102 µM 1.36404343984437 0.0958681457867425 no 361 0.0862769471207477 491 4907387 SGTC_1523 st012844 44.7 µM 1.36319731076261 0.0960072504780131 no 362 0.0864101672883851 508 4274103 SGTC_1631 benzylvanillin 81.9 µM 1.36083822832652 0.0963958703022192 no 363 0.0867824090302549 522 75506 SGTC_2182 6325192 200 µM 1.35907877883165 0.0966864621968888 no 364 0.0870608132993516 473 736248 SGTC_810 3825-7150 143 µM 1.35720906417365 0.0969959701638822 no 365 0.0873573957450808 516 22330411 YGL099W LSG1 SGTC_1023 4482-3888 16 µM 1.35617128350939 0.0971680753918368 no 366 0.0875223382776727 483 3303168 SGTC_3230 9131665 49.47 µM 1.3534037602926 0.0976281360829915 no 367 0.0879633384085834 359 15943720 SGTC_2114 5491910 81.25 µM 1.35306422852656 0.0976846881410924 no 368 0.0880175561321858 511 2849228 SGTC_1362 1611-0397 101 µM 1.35191049910359 0.0978770315810248 no 369 0.0882019742259901 513 27816 SGTC_96 0929-0093 37.281 µM 1.34999445986725 0.0981970761887122 no 370 0.0885088799856489 480 6991579 SGTC_1460 k062-0059 9.15 µM 1.34938612132705 0.098298849858836 no 371 0.0886064881436257 486 1373085 SGTC_3004 9076122 71.4286 µM 1.34913728801954 0.0983405013671753 no 372 0.0886464366434257 520 44782551 SGTC_1495 4469-0029 237 µM 1.34758191199709 0.0986011443148739 no 373 0.0888964457526888 654 793680 SGTC_249 wiskostatin 11.211 µM 1.34500608414872 0.0990339015922486 no 374 0.0893116348957181 506 2775510 A n-wasp and actin depolymerizer. SGTC_2485 5633444 17.78 µM 1.34426530071447 0.0991586152952108 no 375 0.089431306006154 513 5724239 SGTC_532 1548-0774 215 µM 1.33815261997457 0.100192094710246 no 376 0.0904233452581783 538 5932993 SGTC_2399 5884133 200 µM 1.33714796134858 0.100362703386305 no 377 0.0905871721671057 518 722445 SGTC_2646 retinol 96.75 µM 1.33684444390736 0.1004142876539 no 378 0.0906367092294034 492 445354 A vitamin A analog and teratogen. SGTC_374 0880-0231 82.3 µM 1.33526188395591 0.100683564871559 no 379 0.0908953245108565 537 6833587 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 1.33486134734343 0.100751800793364 no 380 0.0909608652481353 626 6708739 YPR165W RHO1 SGTC_925 2064-1272 59.6 µM 1.33434944836239 0.100839057634767 no 381 0.0910446794942371 500 6815817 SGTC_302 1094-0063 18.9 µM 1.33135773372687 0.101350119031275 no 382 0.0915356648821551 456 5440289 SGTC_1903 st060211 78.3 µM 1.32827482591891 0.101878729948747 no 383 0.0920436664968678 553 688960 SGTC_1475 4092-1048 11.7 µM 1.32667523449157 0.102153793370866 no 384 0.0923080683423531 565 2881759 SGTC_3033 9090887 49.47 µM 1.32000154237005 0.103307221199613 no 385 0.09341725151504 562 19325384 SGTC_55 0767-0285 6.563 µM 1.31870000485878 0.103533266118229 no 386 0.0936347125821577 577 3116166 SGTC_2993 9054257 71.4286 µM 1.31528662162734 0.104127791099265 no 387 0.0942067963101043 557 6470217 YGL055W OLE1 SGTC_1411 3909-8223 150 µM 1.31421878943167 0.104314287721864 no 388 0.0943862935892909 547 X1411 SGTC_3006 9075424 71.4286 µM 1.31415533150079 0.10432537824896 no 389 0.0943969684854587 509 7465181 SGTC_1219 1469-0211 33.1 µM 1.31078530308969 0.104915585578559 no 390 0.0949651546365038 511 6822282 SGTC_1283 0922-0125 16.4 µM 1.30792083491643 0.105419149495694 no 391 0.0954500809577401 581 3360884 SGTC_1318 1280-3875 124 µM 1.30746236125372 0.105499909661781 no 392 0.0955278649506172 559 373245 SGTC_1340 1486-1359 257 µM 1.3033092375736 0.106233521865471 no 393 0.0962346043195098 539 4309068 SGTC_1735 st034310 56.75 µM 1.30315731466007 0.10626042737496 no 394 0.096260529798393 549 871153 SGTC_1788 fluconazole 20 µM 1.30179612226251 0.106501713825187 no 395 0.0964930448769664 527 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_558 k064-0027 21.3 µM 1.30159151392473 0.106538017092857 no 396 0.0965280311461087 554 5088526 SGTC_1457 k015-0032 57.3 µM 1.30053634478995 0.106725375572651 no 397 0.0967086039740297 546 4302660 SGTC_750 4073-0104 132 µM 1.30044138586543 0.106742248372753 no 398 0.096724866610691 433 22330957 SGTC_1005 4092-0690 4.4 µM 1.29736431099038 0.107290041434659 no 399 0.097252933067983 529 1529343 SGTC_288 1315-0019 35.1 µM 1.29587308338485 0.107556243594125 no 400 0.0975096069822063 567 6811474 SGTC_2065 5221596 34.26 µM 1.29397293784438 0.10789613173436 no 401 0.0978373843199028 551 788581 SGTC_604 1000-0114 314 µM 1.2930918630897 0.108053996026801 no 402 0.0979896445241718 580 1572745 SGTC_1348 1493-0373 93.8 µM 1.29139921478541 0.108357738387525 no 403 0.0982826413881034 535 3010129 SGTC_183 3914-0051 30.55 µM 1.28931538188261 0.108732521237987 no 404 0.0986442327816127 547 1596232 SGTC_1399 3562-5772 25 µM 1.28728732483664 0.109098166870554 no 405 0.0989970799049671 460 23847490 SGTC_1106 tegaserod maleate 11.7 µM 1.28633976970098 0.109269307515037 no 406 0.0991622543345588 583 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_306 1672-3436 11.6 µM 1.28355576945981 0.109773249382232 no 407 0.0996487171178767 581 6797378 SGTC_3171 9103192 49.47 µM 1.27917297976369 0.110569970629215 no 408 0.100418074323127 527 13018434 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.2767429331638 0.111013496377046 no 409 0.100846509336759 576 16623 A steroid. SGTC_2236 dapsone 200 µM 1.27661201659599 0.111037427048144 no 410 0.10086962866558 581 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1091 telmisartan 47.6 µM 1.27574642402115 0.111195744542112 no 411 0.101022586014187 560 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_979 1426-2828 121 µM 1.2720887743602 0.111866515579576 no 412 0.101670789611388 595 747872 SGTC_235 0330-0087 5 mM 1.26936384109854 0.112368114605626 no 413 0.102155663191828 583 46494818 YHR062C RPP1 SGTC_1120 ficusin 1.78878 µM 1.2604036374095 0.114028811279968 no 414 0.103761895084649 583 6199 A DNA cross-linker. SGTC_2133 5320837 200 µM 1.25594633143223 0.114861416012553 no 415 0.104567714466372 535 2841355 SGTC_337 1315-0038 354 µM 1.2557986935157 0.114889067912715 no 416 0.104594482712787 578 1626437 SGTC_2678 equilin 100 µM 1.25464679765348 0.115104975295485 no 417 0.104803503533552 601 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2363 9053361 176 µM 1.25429034360344 0.115171846226938 no 418 0.104868246243862 598 6469797 YMR079W SEC14 SGTC_1632 st005650 90 µM 1.25327021457381 0.115363375485421 no 419 0.105053692180968 569 2759605 SGTC_3265 9137266 49.47 µM 1.25072752420625 0.115841750684855 no 420 0.105516952451015 507 17224265 SGTC_3167 9103034 49.47 µM 1.24746105343171 0.116458360899129 no 421 0.106114246091094 498 5127859 SGTC_88 0180-0332 8.668 µM 1.24253175240607 0.117393264361894 no 422 0.107020216350458 590 3101745 SGTC_3344 9148862 3.898 µM 1.24160216717161 0.117570165796871 no 423 0.10719169089414 592 4905352 SGTC_2915 7971052 15.16 µM 1.24113598077292 0.117658952769351 no 424 0.107277759819602 420 5741558 SGTC_1425 4048-4433 7.33 µM 1.24110391760499 0.117665061065456 no 425 0.107283681261942 623 23734946 SGTC_318 1488-0629 67.2 µM 1.23825411551805 0.118208868517766 no 426 0.107810925791596 550 3662576 SGTC_3237 9133362 49.47 µM 1.23774849490779 0.118305537831446 no 427 0.107904665741922 571 43845137 SGTC_617 3770-0098 35 µM 1.23699033264874 0.1184505951519 no 428 0.108045335833283 559 5962639 SGTC_507 nimesulide 162 µM 1.23502791584708 0.118826643213451 no 429 0.108410057435377 606 4495 A COX2 inhibitor. SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.23472843687346 0.118884104943384 no 430 0.108465794403294 516 6857784 SGTC_922 1866-0035 480 µM 1.23133300448053 0.11953696734859 no 431 0.109099171346158 692 3156169 SGTC_1441 4106-0040 13 µM 1.22822164647696 0.120137425843142 no 432 0.109681887447044 575 2904180 SGTC_1757 st041620 31.8375 µM 1.22747165416041 0.120282483633281 no 433 0.1098226846731 604 5289815 SGTC_2794 7785382 27.27 µM 1.22614049270603 0.120540250490944 no 434 0.110072905052532 705 2205081 SGTC_834 0312-0008 75.7 µM 1.22459175913881 0.120840637377095 no 435 0.110364537208465 629 6385573 YIL048W NEO1 SGTC_2690 usnic acid 100 µM 1.22356079235869 0.121040891896747 no 436 0.110558978910743 677 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2704 st078022 71.1 µM 1.22056639431799 0.121623845853307 no 437 0.111125118368885 604 54697681 SGTC_236 1509-0011 5.31 µM 1.2197858358916 0.121776129833398 no 438 0.111273036092561 888 3107280 SGTC_1216 1165-0504 9.65 µM 1.21790364443463 0.12214388908412 no 439 0.111630295565852 633 6304004 SGTC_1398 3558-0053 112 µM 1.21722391510183 0.122276892091373 no 440 0.111759516728578 530 4532369 SGTC_2808 7946468 45.46 µM 1.21230949846898 0.123241523558981 no 441 0.112696964648158 661 2970879 SGTC_2725 haloperidol 53.21 µM 1.21060477044703 0.123577380320968 no 442 0.113023457543419 612 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_116 0155-0182 31.788 µM 1.21027602989688 0.12364222074914 no 443 0.11308649614902 741 771486 SGTC_1689 st020265 53.493 µM 1.20749776626594 0.124191153947704 no 444 0.113620252395441 616 5758320 YPR016C TIF6 SGTC_34 0469-0683 81.75 µM 1.20719453603285 0.124251169630607 no 445 0.113678617107775 604 3690923 SGTC_3321 9137793 26.8275 µM 1.20594584268576 0.12449852624459 no 446 0.113919186515789 639 4904192 SGTC_1960 st011366 51.8 µM 1.20447620083707 0.124790091871516 no 447 0.114202787627253 603 3972846 SGTC_1717 st033143 58.0435 µM 1.20215390877514 0.125251788826671 no 448 0.114651951566345 667 674616 SGTC_1851 st056236 18.9 µM 1.20025314495879 0.125630567934719 no 449 0.115020520466932 641 5393171 SGTC_2752 diclazuril 33.15 µM 1.19893855036687 0.12589300389164 no 450 0.115275920226322 797 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_446 go6976 132 µM 1.19854669334461 0.125971305248201 no 451 0.115352128235691 586 3501 A protein kinase C inhibitor. SGTC_2383 9036125 200 µM 1.19760270546285 0.126160073500056 no 452 0.115535861181015 573 79580 SGTC_86 0417-1630 471.922 µM 1.19377010512848 0.126928499460341 no 453 0.116283954351837 744 3634867 SGTC_1259 0671-0132 43 µM 1.19302662454124 0.12707794180654 no 454 0.116429473008599 622 X1259 SGTC_1276 0871-0068 94.2 µM 1.19233433929641 0.127217203745641 no 455 0.116565087492529 593 3414906 SGTC_984 1492-0255 2.91 µM 1.1862178347742 0.128452229791491 no 456 0.117768142407116 596 1585198 SGTC_1074 carmofur 3.8 µM 1.1850446588512 0.128690061982387 no 457 0.117999895042893 698 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_277 nystatin 15.5 µM 1.18284634237841 0.129136538149528 no 458 0.118435025192236 650 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_439 amiodarone 34.4 µM 1.18264317487804 0.129177855437629 no 459 0.118475296918825 663 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_892 0929-0076 29 µM 1.18204260334877 0.129300044629918 no 460 0.118594398394878 676 5751038 SGTC_2214 7179297 48.276 µM 1.18133515220907 0.129444081726524 no 461 0.118734804045834 634 769744 SGTC_1330 1469-0054 61.8 µM 1.17600487979416 0.130532900129859 no 462 0.119796463037271 649 7102664 SGTC_829 1635-0120 117 µM 1.17383009263978 0.130978959445155 no 463 0.120231543972046 674 285054 SGTC_3318 9139014 38.6185 µM 1.1661767392108 0.132557068428131 no 464 0.121771497561135 620 16643984 SGTC_957 1187-1561 14.1 µM 1.16492725197008 0.132815949385591 no 465 0.122024220630469 657 1538454 SGTC_727 3032-0951 202 µM 1.16336954866297 0.133139176849766 no 466 0.12233979946741 607 3652836 SGTC_1927 st060202 13.8 µM 1.16235336490275 0.133350329156394 no 467 0.122545979055584 641 688887 SGTC_762 1165-0429 115 µM 1.16017491946351 0.133803763217106 no 468 0.122988798065864 650 5967793 SGTC_2235 salicylic acid 500 µM 1.15974111328373 0.133894184498113 no 469 0.123077112893209 635 338 A COX inhibitor and kinase inhibitor. SGTC_1718 roemerine 11.9335 µM 1.15954582293637 0.133934903947153 no 470 0.123116884863207 693 235224 An aporphine alkaloid with mutagenic activity. SGTC_1604 st002052 72.4 µM 1.15911193723054 0.134025402707802 no 471 0.123205280348076 655 6254834 YHR062C RPP1 SGTC_3086 9117350 49.47 µM 1.15698271763401 0.134470118773366 no 472 0.123639710653433 572 2679265 SGTC_46 0329-0187a 2.197 µM 1.1559425508651 0.134687739482492 no 473 0.123852328180451 749 46494817 SGTC_3030 9087619 49.47 µM 1.15406201322769 0.135081793370736 no 474 0.124237372857767 620 25236973 SGTC_1760 st045453 10.4495 µM 1.15342061522267 0.13521637459571 no 475 0.124368891964485 686 3323419 YIL048W NEO1 SGTC_2975 9084847 53.72 µM 1.15293505056915 0.135318319232426 no 476 0.124468522067766 680 27211724 SGTC_1063 disulfiram 1.84 µM 1.15040615710895 0.135850113798791 no 477 0.12498831269077 649 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_505 gw-5074 63.9 µM 1.14860928596022 0.136228841851987 no 478 0.125358563148626 671 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1650 st011916 45.8 µM 1.14827228914483 0.136299951337124 no 479 0.125428087483093 648 242528 SGTC_3132 9126706 49.47 µM 1.14511175103009 0.136968090494392 no 480 0.126081434158539 637 850858 SGTC_816 0325-0417 81.3 µM 1.14273807804447 0.137471355358783 no 481 0.126573677529988 640 68101 SGTC_1846 st056244 14.8 µM 1.14147445467635 0.137739782398681 no 482 0.126836268267038 710 5393182 SGTC_761 k216-0224 480 µM 1.14048032888271 0.137951212238589 no 483 0.127043121707737 721 1340404 SGTC_875 0709-0210 25.7 µM 1.14003846803825 0.13804525786065 no 484 0.127135137546466 714 6251364 SGTC_227 fluconazole 33.516 µM 1.13772906149948 0.13853750314586 no 485 0.127616817202407 706 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_3043 9092303 49.47 µM 1.1362097319163 0.138861996609996 no 486 0.127934399262926 611 25236084 SGTC_1785 bathophenanthroline 24 µM 1.13542114127234 0.139030625106973 no 487 0.128099452897412 657 72812 An iron chelator. SGTC_2398 5228213 48.84 µM 1.13472328976627 0.139179966593269 no 488 0.128245637955983 771 80771 YMR134W ERG29 SGTC_3142 9086498 49.47 µM 1.13467923345247 0.139189398386523 no 489 0.128254870703391 639 25236367 SGTC_534 k292-0788 63.4 µM 1.13193303708155 0.139778176385721 no 490 0.12883129398426 753 4146317 SGTC_10 0279-0212 42.575 µM 1.13180823950993 0.139804972848101 no 491 0.128857531463492 779 39851 YBR002C RER2 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.13035681943556 0.140116877400934 no 492 0.129162950695771 645 279621 SGTC_3238 9133470 49.47 µM 1.12997082287619 0.14019990608507 no 493 0.129244259539782 672 3534688 SGTC_2642 cholecalciferol 100 µM 1.12981934390361 0.140232498664679 no 494 0.129276177754394 659 9821465 A vitamin D precursor, similar to steriods. SGTC_2324 6149169 200 µM 1.12968174720325 0.140262108761443 no 495 0.129305175563083 644 2888231 SGTC_2159 5658611 73.75 µM 1.12931537813465 0.140340970190789 no 496 0.12938240797221 668 793844 SGTC_115 0527-0192 112.043 µM 1.1273924356683 0.140755379822893 no 497 0.129788297923013 770 4233931 SGTC_1700 st030840 7.9285 µM 1.12560723896782 0.141140846681416 no 498 0.13016590132558 726 5499307 SGTC_2268 7933382 153.85 µM 1.12546318498503 0.141171982577446 no 499 0.130196404623921 754 935025 YOR257W CDC31 SGTC_2623 humulene 100 µM 1.12405306165764 0.141477013218397 no 500 0.130495258132824 590 6187145 An anti-inflammatory. SGTC_1450 4112-4260 37.6 µM 1.1238052783279 0.141530658536484 no 501 0.130547820886915 712 1633175 SGTC_1290 0986-0249 10.2 µM 1.12097427690669 0.142144551249047 no 502 0.131149405944307 625 53329 SGTC_837 0091-0265 12.5 µM 1.12005325931112 0.142344658621519 no 503 0.131345533465206 716 759367 SGTC_1754 st042065 16.137 µM 1.12001768432479 0.142352391737909 no 504 0.131353113096052 789 1126236 YIL048W NEO1 SGTC_3296 9122258 64.045 µM 1.11909608597813 0.142552823329924 no 505 0.131549574729411 678 4730474 SGTC_946 3434-1334 87.4 µM 1.11755188171722 0.142889088480829 no 506 0.13187921475926 660 4047976 SGTC_3175 9106517 49.47 µM 1.11742875640095 0.142915923245557 no 507 0.131905522726456 667 41468073 SGTC_2044 5102272 200 µM 1.11629865553324 0.143162384164154 no 508 0.132147158465661 632 592666 SGTC_222 nsc-310342 10.666 µM 1.1140284437412 0.143658356304802 no 509 0.13263349218544 588 432556 SGTC_888 0916-0002 6.97 µM 1.11246890669331 0.143999738783657 no 510 0.132968295914471 724 2802138 YIL048W NEO1 SGTC_2721 ifenprodil 61.44 µM 1.11244739253909 0.144004452052271 no 511 0.132972918669963 689 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2959 9079155 11 µM 1.11112712777452 0.144293891559408 no 512 0.133256816267958 625 16189457 SGTC_85 0868-0259 160.055 µM 1.10519798611573 0.145598560149357 no 513 0.134536904659523 667 83173 SGTC_2619 obliquin 87.91 µM 1.10333382298587 0.146010390868731 no 514 0.134941111776357 782 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1923 st058458 19.1 µM 1.10240823149265 0.146215162935865 no 515 0.135142117263808 761 3534982 SGTC_149 3970-0822 46.1 µM 1.10183995922929 0.146340979447716 no 516 0.135265627415136 839 3114250 YBL034C STU1 SGTC_1522 st012842 45.6 µM 1.10158010147718 0.146398536639879 no 517 0.135322131523275 640 3491067 YOR116C RPO31 SGTC_576 1073-0113 22.7 µM 1.10147181099002 0.146422526926984 no 518 0.135345683248201 893 5439563 SGTC_2066 5222451 176 µM 1.09699658808955 0.147416260239578 no 519 0.136321441797253 762 2281147 SGTC_945 3381-0768 11.3 µM 1.09680915757153 0.147457977973508 no 520 0.136362413092971 751 1126236 YIL048W NEO1 SGTC_112 phenothiazine 287.218 µM 1.09620463299828 0.147592585172374 no 521 0.136494616289144 739 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.09397543074081 0.148089664393276 no 522 0.136982876990586 752 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2151 5563267 85.4165 µM 1.09046818891352 0.148873993092359 no 523 0.137753479376312 741 5310824 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.08950312140345 0.14909029839797 no 524 0.137966039560374 732 94937 An inhibitor of serotonin biosynthesis. SGTC_2466 5983409 37.09 µM 1.08929057813399 0.149137964954312 no 525 0.138012883156367 695 2879657 SGTC_1108 betulinic acid 729.144 nM 1.08893738487228 0.149217197246326 no 526 0.138090749376379 716 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_559 1550-0661 158 µM 1.08806287276927 0.149413498598117 no 527 0.138283676272726 716 5830875 SGTC_3150 9097574 49.47 µM 1.08776584403279 0.149480211710309 no 528 0.138349245830624 700 17217476 SGTC_345 1362-0200 395 µM 1.08630986057407 0.149807515386507 no 529 0.138670962968151 676 1419823 SGTC_1458 k015-0034 6.33 µM 1.07975858732322 0.151286146266358 no 530 0.140124848473167 683 3598957 SGTC_3196 9111891 49.47 µM 1.07801645778987 0.151680975538353 no 531 0.140513205798736 692 18891510 SGTC_3127 9126946 49.47 µM 1.07739267706967 0.151822513066629 no 532 0.14065243712934 637 27243249 SGTC_903 1134-0042 114 µM 1.07504960254781 0.152354946675901 no 533 0.141176260619262 716 701009 SGTC_3217 9129673 49.47 µM 1.07459802206209 0.152457704825184 no 534 0.14127736889446 690 17248312 SGTC_1749 st037932 54.2 µM 1.07427987593491 0.152530127297901 no 535 0.141348630859579 676 594497 SGTC_8 0354-0001 70 µM 1.07396897262333 0.152600923073878 no 536 0.141418294031388 827 4993152 SGTC_2825 7998094 58.44 µM 1.0736252988493 0.152679206374558 no 537 0.14149532705433 699 2987815 SGTC_2896 9052656 71.43 µM 1.06958443920434 0.153601646314465 no 538 0.142403201235295 808 6469436 SGTC_2389 9091542 195.52 µM 1.06914556811058 0.15370205269555 no 539 0.142502040648701 753 3626624 YOL127W RPL25 SGTC_1402 3909-7673 35.9 µM 1.06688978995246 0.154218822606517 no 540 0.143010802936238 720 5328014 SGTC_2107 5363541 170.161 µM 1.06603649244951 0.154414601352816 no 541 0.143203572964378 762 244052 SGTC_2385 9074692 200 µM 1.06368293004726 0.15495544893704 no 542 0.143736179939968 733 17046906 SGTC_1272 0839-0021 27 µM 1.06300010684015 0.155112595260912 no 543 0.14389095144302 770 5027250 SGTC_462 ag-879 158 µM 1.06206086212012 0.155328926804451 no 544 0.144104028105622 777 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1218 1348-1416 30.7 µM 1.0610922387558 0.155552233441144 no 545 0.144323992334466 726 6787668 SGTC_1168 k815-0004 80.5 µM 1.06076638910857 0.155627402468974 no 546 0.144398040223493 736 642433 SGTC_1077 5-fluorocytosine 377 nM 1.05917568327456 0.155994700314761 no 547 0.144759888608632 717 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2435 5706476 10.6 µM 1.05715329402054 0.156462499217074 no 548 0.145220815911042 782 5725375 SGTC_1397 3532-0190 20.1 µM 1.05677908494629 0.156549158699223 no 549 0.1453062108954 674 5322280 SGTC_164 4100-3994 89.624 µM 1.04687696469586 0.158853775633194 no 550 0.147578163648303 822 4615967 SGTC_1932 st074806 40.9 µM 1.04612526455686 0.159029629658447 no 551 0.147751601038471 796 17251235 SGTC_654 1124-0271 80.9 µM 1.04584141319883 0.159096067497324 no 552 0.147817128650299 766 5403748 SGTC_1837 st055472 66.5 µM 1.04554826344181 0.15916470078964 no 553 0.147884823236839 765 676091 SGTC_845 0330-0138 4.51 µM 1.04457768526546 0.159392074480158 no 554 0.148109098715623 758 9039800 SGTC_1690 st023502 41.2 µM 1.04437019844637 0.159440709212397 no 555 0.148157073059935 737 24207482 SGTC_1431 4049-0260 9.09 µM 1.04358408448104 0.159625061773611 no 556 0.14833892977718 776 3854841 SGTC_954 1189-0853 2.85 µM 1.04242333833405 0.159897524745487 no 557 0.148607725422536 787 2828194 SGTC_346 4513-0042 7.16 µM 1.04218589014978 0.159953298624271 no 558 0.14866275173288 791 2827372 SGTC_3047 9092122 49.47 µM 1.04175948489212 0.160053488307004 no 559 0.148761601197134 723 17173831 SGTC_125 0133-0007 11.75 µM 1.03962628773073 0.160555327834415 no 560 0.149256779442189 832 26541 SGTC_3240 9133527 49.47 µM 1.0385061104761 0.160819263245994 no 561 0.149517245980908 746 17617455 SGTC_1635 st007035 42.4 µM 1.03785768195893 0.160972174913707 no 562 0.14966815881509 895 3716403 SGTC_1555 citronellol 128 µM 1.03606119360043 0.161396316231062 no 563 0.150086797476905 739 8842 A terpine precursor. SGTC_117 lucigenin 22.078 µM 1.03165508962978 0.162439656769004 no 564 0.151116861583401 802 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1244 0416-0015 52.5 µM 1.02818495098725 0.163264448902015 no 565 0.151931418007298 766 96201 SGTC_1656 st012921 11 µM 1.02808079490184 0.163289246996615 no 566 0.151955911891447 723 6732821 SGTC_2946 9065502 71.43 µM 1.02675767737319 0.163604475594162 no 567 0.1522672913594 615 16489101 SGTC_2522 biochanin a 4.94 µM 1.02536709986495 0.163936201891056 no 568 0.152595002932681 744 5280373 A possible chelator. SGTC_228 caffeine 993.056 µM 1.02434009925205 0.164181475856855 no 569 0.152837332058317 731 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3106 9121286 49.47 µM 1.02411329306338 0.164235675032438 no 570 0.15289088320247 719 15943471 SGTC_2869 9037858 32.47 µM 1.02287572080359 0.164531618214501 no 571 0.15318330516943 724 27187042 SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.02180267745774 0.164788496830608 no 572 0.153437150942159 715 77254 SGTC_618 k072-0232 33.2 µM 1.0190118727792 0.165457810554068 no 573 0.154098664993587 759 5872756 YGL099W LSG1 SGTC_737 1950-0117 57.9 µM 1.01889016705966 0.16548703898331 no 574 0.154127556188438 782 5393513 SGTC_451 chloral hydrate 100 µM 1.01678830847408 0.165992341007778 no 575 0.154627072568017 844 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1910 st062352 60.4 µM 1.01566368668562 0.16626311725245 no 576 0.154894782994866 766 2245730 SGTC_2739 tacrine 100.86 µM 1.014098263213 0.166640500370505 no 577 0.15526793334769 739 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2954 9074818 52.69 µM 1.01382310689892 0.166706890521672 no 578 0.155333583681306 759 16648742 SGTC_3205 9113483 49.47 µM 1.01262553092676 0.166996042315022 no 579 0.155619530109065 796 17018033 SGTC_2071 5230951 39.92 µM 1.00834398706118 0.168032454074399 no 580 0.156644676496726 836 1799272 SGTC_1809 st050081 57.6 µM 1.00824500928672 0.168056461976015 no 581 0.156668427574129 794 5036894 SGTC_874 0599-0792 117 µM 1.00748161393924 0.16824170417902 no 582 0.156851694423786 876 765305 SGTC_748 act1.228 77.9 µM 1.00465837860926 0.168927918836421 no 583 0.157530688116601 819 4421505 YNR035C ARC35 SGTC_952 1185-0122 232 µM 1.00217683244964 0.169532565246042 no 584 0.158129097507187 782 678600 SGTC_290 2043-6722 48.1 µM 1.00193410893033 0.169591781023182 no 585 0.158187708771307 798 773758 YLR208W SEC13 SGTC_303 1348-1668 34.2 µM 1.00177522274303 0.169630550702549 no 586 0.158226083273124 795 5380509 SGTC_1563 conessine 56.1 µM 1.0016917649494 0.169650917442995 no 587 0.158246242609182 910 441082 An anti-amoebic, histamine inhibitor. SGTC_662 k832-1615 104 µM 1.00086434763186 0.169852922254786 no 588 0.158446197496508 780 5878478 SGTC_1581 himbacine 57.9 µM 1.00083576489228 0.16985990317013 no 589 0.158453107803568 800 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2437 5741531 144.16 µM 1.00066229255276 0.169902275193602 no 590 0.1584950515906 836 2262990 SGTC_2325 6158266 200 µM 1.00055857496409 0.169927612291194 no 591 0.158520132890853 769 3623240 SGTC_1189 1431-2119 7.28 µM 1.00047717754054 0.169947498507594 no 592 0.158539818484421 833 3107275 SGTC_2823 7987624 58.44 µM 1.00039941026111 0.1699664992365 no 593 0.158558627641816 789 2239440 SGTC_263 alizarin 107.927 µM 0.999832044582165 0.170105163802853 no 594 0.158695897638476 864 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2953 9074162 66.49 µM 0.999334511788077 0.170226820809771 no 595 0.15881633617759 736 16451992 SGTC_2068 5226020 147 µM 0.998438415727794 0.17044607531884 no 596 0.159033406637384 835 1810509 SGTC_3091 9116372 49.47 µM 0.996852096758272 0.170834655069239 no 597 0.159418153237216 754 17169793 SGTC_3139 9095020 49.47 µM 0.995942552382218 0.171057709720385 no 598 0.159639029233403 644 25236292 SGTC_2630 antimycin a 100 µM 0.995082993287249 0.171268677219479 no 599 0.15984795065407 849 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2135 5326629 150.42 µM 0.98970281263555 0.172592948969138 no 600 0.161159699919488 749 5020077 SGTC_2451 5856223 45.7 µM 0.988840041426681 0.17280591637174 no 601 0.161370704962243 788 2179896 SGTC_2708 st078559 56 µM 0.986636522742979 0.173350595119596 no 602 0.161910429432062 730 17250902 SGTC_1468 k284-1086 134 µM 0.986518242286662 0.173379863256923 no 603 0.16193943397741 874 15996457 SGTC_2670 beta-carotene 100 µM 0.986124652471931 0.173477278502203 no 604 0.16203597381573 766 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1428 4049-0204 61.7 µM 0.98535691136127 0.173667398100617 no 605 0.16222439345561 853 X1428 SGTC_299 1273-0059 1.44 µM 0.985343959528327 0.173670606564859 no 606 0.162227573327928 773 2848077 SGTC_362 0310-0100 9.03 µM 0.985300648808759 0.173681335891218 no 607 0.162238207064204 782 790235 SGTC_291 SEC14.278 35.5 µM 0.982374404708464 0.174407228402933 no 608 0.162957715548721 836 1068044 SGTC_1257 0669-0121 16 µM 0.982084409111854 0.174479270356074 no 609 0.163029132831911 900 4307855 SGTC_257 daunorubicin 18.5 µM 0.980906433230379 0.174772102479607 no 610 0.163319442369185 826 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3264 9137442 49.47 µM 0.979419099840579 0.175142282894453 no 611 0.163686471809255 779 17015726 SGTC_2650 prasterone 100 µM 0.978880695928819 0.175276408032765 no 612 0.16381946570744 759 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_19 0279-0214 38.434 µM 0.978797827756266 0.175297057619701 no 613 0.163839941623706 902 3566274 YBR002C RER2 SGTC_3093 9117344 49.47 µM 0.978712260653589 0.17531838136089 no 614 0.163861086162165 782 24824913 SGTC_2691 st077356 60.2 µM 0.977887815291907 0.175523921443081 no 615 0.164064906081331 857 2839272 SGTC_1278 0874-0585 172 µM 0.97636406156244 0.175904205865912 no 616 0.164442042147668 830 766306 SGTC_1888 azatryptophan 97.5 µM 0.97610964455218 0.175967751716107 no 617 0.164505066233208 751 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2249 haloperidol 116.36 µM 0.976035721207168 0.175986218308049 no 618 0.164523381431149 939 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2695 st077686 51.995 µM 0.975887391915528 0.176023275750487 no 619 0.16456013538224 780 2876092 SGTC_2891 9063876 19.48 µM 0.970670743523977 0.177329704122554 no 620 0.165856132611837 781 6472478 SGTC_679 0422-0091 41.4 µM 0.968302121796034 0.177924904390813 no 621 0.166446752708793 862 627384 YHR062C RPP1 SGTC_1836 st055642 81 µM 0.965756453008832 0.178565996925873 no 622 0.167083031811082 840 8571 SGTC_3113 9123498 49.47 µM 0.96553065730901 0.178622930701757 no 623 0.16713954411236 863 8897275 SGTC_2972 9093619 59.92 µM 0.963761914077066 0.179069309946281 no 624 0.16758265265816 810 25236256 SGTC_2048 5246248 200 µM 0.961877628572035 0.179545620049481 no 625 0.168055538724805 832 677046 SGTC_1463 k081-0032 34.1 µM 0.960021022619178 0.180015711378333 no 626 0.168522317297069 723 977755 SGTC_2328 6201408 200 µM 0.957677492516752 0.180610193881711 no 627 0.169112704832703 802 2890418 SGTC_970 1315-0089 19.5 µM 0.957625304305776 0.180623446446188 no 628 0.169125867307891 788 6811083 YLR033W RSC58 SGTC_3269 9137823 49.47 µM 0.956980880543592 0.180787140312284 no 629 0.169288452705176 771 17682936 SGTC_630 4356-0227 183 µM 0.95690412538074 0.180806643538312 no 630 0.169307824393636 813 779312 SGTC_2124 5246320 200 µM 0.955872261523256 0.181068964673227 no 631 0.169568387293698 823 579342 SGTC_1062 mesoridazine 14.2 µM 0.954560972703167 0.181402665257416 no 632 0.169899880671312 850 4078 A neuroleptic. SGTC_665 3914-0008 307 µM 0.951841518153125 0.182095946242631 no 633 0.170588681211662 824 1069549 SGTC_2518 prenyletin 46.28 µM 0.951439678138478 0.182198529140831 no 634 0.170690613177386 761 3873459 A coumarin with calcium channel inhibitory activity. SGTC_997 3996-0078 137 µM 0.950968602238032 0.182318832760002 no 635 0.170810157360504 866 735687 SGTC_1915 st067105 30.6 µM 0.950734561115719 0.182378620760583 no 636 0.170869569521601 839 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1828 st055811 49 µM 0.949632505947313 0.1826603157104 no 637 0.171149507798358 823 5877589 SGTC_3117 9124945 49.47 µM 0.947804538328289 0.1831281589049 no 638 0.171614484859612 754 17592065 SGTC_1742 st038235 28.8875 µM 0.947214086698763 0.183279436460426 no 639 0.171764849342784 832 564103 YBR002C RER2 SGTC_393 acivicin 6.25 µM 0.944863513984875 0.183882440803051 no 640 0.172364280432877 801 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1924 st058459 75.1 µM 0.940496258146859 0.185006071026962 no 641 0.173481534055953 849 688683 SGTC_1444 4112-3581 28 µM 0.940039727098753 0.185123775478984 no 642 0.173598591668428 892 2877249 SGTC_680 0417-1641 114 µM 0.938841583699056 0.185432906221866 no 643 0.173906042617103 825 2835990 SGTC_1203 3992-3522 103 µM 0.935270240212297 0.186356241393663 no 644 0.174824524005802 906 5322312 SGTC_2206 7254556 146.969 µM 0.934761903360132 0.186487897985761 no 645 0.17495550840956 866 4398905 SGTC_2950 9072895 21.46 µM 0.934186061206882 0.186637107669053 no 646 0.175103962274609 877 17332245 SGTC_1776 st049249 45.9 µM 0.933475188885869 0.18682140768938 no 647 0.175287337503194 890 1822314 SGTC_908 3448-7491 47.7 µM 0.932991169423152 0.186946958504193 no 648 0.175412263870269 924 1203031 SGTC_1124 fisetin 1.16336 µM 0.932227150115734 0.187145245272636 no 649 0.175609573575397 830 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_3354 9151612 71.43 µM 0.930634576629634 0.187558985570928 no 650 0.176021311177223 900 27261949 SGTC_3298 9116858 71.43 µM 0.928201515267476 0.188192169554703 no 651 0.17665152429501 891 2506942 SGTC_3239 9133757 49.47 µM 0.927892207723307 0.188272758666861 no 652 0.176731743427663 896 17036923 SGTC_2215 7188065 200 µM 0.926887545076107 0.18853466723801 no 653 0.176992462260857 856 940217 SGTC_557 1315-0110 16.2 µM 0.926478969649658 0.188641244242662 no 654 0.177098560672571 902 6833801 SGTC_3071 9117417 49.47 µM 0.926154720541951 0.188725851133733 no 655 0.177182789909149 790 45595590 YGL055W OLE1 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.925615193624118 0.188866682670592 no 656 0.177322997296633 907 442882 SGTC_2986 9022445 71.43 µM 0.925278986082651 0.188954474933584 no 657 0.177410403299263 891 6459286 SGTC_1507 4075-3230 155 µM 0.923187468224611 0.189501187456062 no 658 0.177954759188095 821 659771 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.918041765162983 0.190850386572516 no 659 0.179298500398513 967 1377 SGTC_3310 9130229 44.1445 µM 0.915705733457146 0.191464832406483 no 660 0.17991062852098 872 7761258 SGTC_1466 k213-0079 57.5 µM 0.91547234138978 0.1915262879918 no 661 0.17997185804891 909 3657981 SGTC_3153 9100258 49.47 µM 0.91538561470061 0.191549127491798 no 662 0.179994613802758 813 25236848 SGTC_490 phenamil 164 µM 0.914492924109603 0.191784314793695 no 663 0.180228947127444 808 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_983 1491-0821 12.2 µM 0.913910814601819 0.191937771932972 no 664 0.180381855294098 915 46495113 SGTC_1488 4013-0813 75.9 µM 0.913225817885381 0.192118448677635 no 665 0.180561894020436 865 2910057 SGTC_676 falcarinol 140 µM 0.913036158545128 0.192168492170527 no 666 0.18061176238787 937 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1941 st076221 61.8 µM 0.911708495125747 0.192519032558871 no 667 0.180961095405245 932 2828568 SGTC_2460 5552655 174.22 µM 0.910621757723689 0.192806252444618 no 668 0.181247351198219 855 5401989 SGTC_1648 st011736 69.8 µM 0.910256450432454 0.192902860304201 no 669 0.181343639870067 880 2855514 SGTC_2809 7964133 12.99 µM 0.909631745326833 0.193068136078845 no 670 0.181508375515591 884 1253665 SGTC_2296 7971656 126.45 µM 0.90878313726433 0.193292787425895 no 671 0.181732304688528 870 666570 SGTC_1047 2043-3044 82 µM 0.908255553135952 0.193432534742952 no 672 0.18187160973426 927 669592 SGTC_2591 skatole 100 µM 0.907647877139996 0.193593573284264 no 673 0.182032145241035 878 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_3058 9093861 49.47 µM 0.907467632733639 0.193641355076258 no 674 0.18207977913997 887 17217477 SGTC_455 paf C-16 10 µM 0.905581662781609 0.194141746434983 no 675 0.182578659098548 868 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2585 alliin 100 µM 0.905261314891467 0.194226820313943 no 676 0.182663482799131 907 87310 A garlic compound which reacts with lipids. SGTC_1132 3456-3614 2.5 µM 0.904744298222885 0.194364170842894 no 677 0.182800433572092 993 3125502 SGTC_518 1021-0119 62.6 µM 0.90334294002647 0.194736752597982 no 678 0.183171956732371 835 1097762 SGTC_1818 st052136 56.3 µM 0.901437088525574 0.195244161638892 no 679 0.183677984598692 859 674169 SGTC_1028 k015-0029 4.8 µM 0.901339033909036 0.195270289161527 no 680 0.183704042886909 899 4588309 SGTC_2342 7990637 118.86 µM 0.893377279549156 0.197398852811732 no 681 0.185827582858911 926 2033102 YER133W GLC7 SGTC_1559 coumarin 343 70.1 µM 0.89244482453857 0.197649057979105 no 682 0.186077277139116 885 108770 A hepatotoxic, DNA x-linker. SGTC_478 N-arachidonylglycine 10 µM 0.891343712758798 0.197944765425347 no 683 0.186372402264568 822 5283389 SGTC_2318 6029776 164 µM 0.891063230927701 0.198020132491487 no 684 0.186447624630166 917 818325 SGTC_1565 sinapyl alcohol 95.1 µM 0.890950979094091 0.198050300053763 no 685 0.186477734695058 898 5280507 A phenol propionate derived from cinnamic acid. SGTC_1041 0206-0046 107 µM 0.890255798326719 0.198237190963112 no 686 0.186664274784601 918 50494 SGTC_1987 st072290 61.9 µM 0.890114949234385 0.198275069496786 no 687 0.186702083344029 951 54697379 SGTC_2125 5246583 200 µM 0.889085918279875 0.198551939220017 no 688 0.186978453139951 998 835267 SGTC_1531 st059297 52.4 µM 0.887736992246733 0.198915232508612 no 689 0.187341121213395 929 7566702 SGTC_172 1112-0046 2.638 µM 0.887499023623256 0.198979363859153 no 690 0.187405145816509 838 2802135 YIL048W NEO1 SGTC_1035 k081-0041 55.2 µM 0.886050909723274 0.19936989183632 no 691 0.187795047166127 974 731709 SGTC_2890 9046729 58.44 µM 0.885272189559387 0.199580088095399 no 692 0.188004922777334 859 903329 SGTC_93 0109-0045 59.227 µM 0.88178792560315 0.20052221120037 no 693 0.188945751185097 1079 88733 SGTC_1022 4477-0945 21.3 µM 0.88042114218953 0.200892508979374 no 694 0.189315603669204 928 4648966 SGTC_2702 st077768 96.8 µM 0.880193402950782 0.200954249418536 no 695 0.189377273343277 832 6484119 SGTC_802 4112-3352 742 µM 0.878671834782268 0.201367040791249 no 696 0.189789617095364 984 704594 SGTC_3090 9117696 49.47 µM 0.877376853524944 0.20171876066659 no 697 0.190140990531053 919 7923821 SGTC_1422 4031-0024 15.5 µM 0.875211555821317 0.20230768176254 no 698 0.190729403361011 928 782427 SGTC_2996 9066192 71.4286 µM 0.873554325385299 0.20275911188135 no 699 0.191180504582587 920 6472854 SGTC_3262 9137218 49.47 µM 0.872922086578468 0.202931492426844 no 700 0.191352773402348 814 17650664 SGTC_1626 st003712 1.76 µM 0.871933548139811 0.203201193780604 no 701 0.191622315298347 874 24207035 SGTC_2490 carminic acid 95.39 µM 0.871778520667732 0.203243509075768 no 702 0.191664607272623 891 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1820 st053765 18.6 µM 0.8706090550941 0.203562888272174 no 703 0.191983825285022 925 3690829 SGTC_45 0kpi-0036 14.9 µM 0.870590939246116 0.203567838034678 no 704 0.191988772755461 889 2795021 SGTC_2416 tofa 880 nM 0.870047288587565 0.20371641218134 no 705 0.1921372810263 841 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2862 9027634 71.43 µM 0.86974307741036 0.203799578176772 no 706 0.192220412616236 855 5012562 SGTC_1988 st071872 53.4 µM 0.865938874912753 0.20484128829578 no 707 0.193261841517903 974 16414116 SGTC_2428 5615643 7.78 µM 0.864646132337024 0.205196001371638 no 708 0.193616521938067 929 2253075 SGTC_1317 1273-0028 910 nM 0.864524047734509 0.20522951877462 no 709 0.19365003790819 974 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_466 geldanamycin 89.2 µM 0.86362823789792 0.20547555606463 no 710 0.193896073405254 868 5288382 HSP90 inhibitor. SGTC_766 1391-0721 126 µM 0.863409073543059 0.205535776974023 no 711 0.19395629621374 973 1020919 YIL115C NUP159 SGTC_550 4123-0385 25.7 µM 0.862892821731778 0.205677671528299 no 712 0.194098198874872 937 5731123 SGTC_1343 1487-0095 224 µM 0.862635129164213 0.205748521448884 no 713 0.194169054751209 958 4560101 YGL055W OLE1 SGTC_603 3794-0023 45.9 µM 0.862261436790127 0.205851290048676 no 714 0.19427183424688 957 3802260 SGTC_805 3852-0218 479 µM 0.862056539634564 0.205907651443985 no 715 0.19432820275179 889 6615355 SGTC_1339 1486-1321 22.7 µM 0.861396235853919 0.206089344557235 no 716 0.19450992424924 951 3469382 SGTC_2309 7664088 163.95 µM 0.855560232303811 0.207699343022592 no 717 0.196120537316 999 704922 SGTC_1552 6-methylflavone 10.6 µM 0.855136568991023 0.20781650905112 no 718 0.196237773443846 945 689013 SGTC_2667 digitoxin 100 µM 0.854425975247896 0.208013114624234 no 719 0.196434504348364 939 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_444 curcumin 90.4 µM 0.852531674484935 0.208537761962377 no 720 0.196959533313545 930 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_538 2922-0838 53.3 µM 0.851418275307352 0.208846493774036 no 721 0.197268521705841 1034 777039 SGTC_2898 9056270 58.44 µM 0.850562383847747 0.209084004852834 no 722 0.197506246281029 924 19154699 SGTC_1415 3966-0071 78.1 µM 0.85040689514743 0.209127170251243 no 723 0.197549451982615 964 2893185 SGTC_1887 st057648 70.8 µM 0.849822502031575 0.209289451215404 no 724 0.197711888597337 973 688672 SGTC_2085 5307070 144.047 µM 0.847904099886866 0.209822695823193 no 725 0.198245690538963 916 2840351 SGTC_1937 st074714 47.2 µM 0.847302249205789 0.209990152423096 no 726 0.198413336648748 996 17250970 SGTC_720 r052-1644 49.9 µM 0.846730968868735 0.210149175875435 no 727 0.198572546466722 882 1422863 YOR257W CDC31 SGTC_1795 st049545 62.3 µM 0.846328491178217 0.210261253335741 no 728 0.198684759016761 983 5291882 SGTC_1679 SEC14.276 6.7 µM 0.845875752588819 0.210387368826957 no 729 0.198811030214584 1034 1005053 YMR079W SEC14 SGTC_329 k048-0121 21.3 µM 0.844652733881699 0.210728276558251 no 730 0.199152378411015 951 6832902 SGTC_2193 5925765 200 µM 0.841699989762185 0.211552667236306 no 731 0.199977951996741 972 877370 SGTC_556 4058-0063 51.5 µM 0.841425162784447 0.211629493419841 no 732 0.200054896883468 1024 6615692 SGTC_1252 0493-0875 34.8 µM 0.841323583484985 0.211657893418545 no 733 0.200083341127396 935 3960963 SGTC_1875 nocodazole 6 µM 0.840505095897738 0.211886811261186 no 734 0.200312622792581 989 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_3234 9132280 49.47 µM 0.840020215784141 0.212022492737752 no 735 0.200448525938604 973 17612295 SGTC_1575 cyproterone acetate 48 µM 0.83973438235838 0.212102499815749 no 736 0.200528665829259 957 9880 An androgen receptor antagonist and liver toxin. SGTC_2400 5203494 178.7 µM 0.839648161112591 0.212126637302054 no 737 0.200552843689998 920 6777674 SGTC_258 haloperidol 50.781 µM 0.838572168082571 0.212427994714959 no 738 0.200854717107264 963 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_973 1325-0077 65.9 µM 0.838049760591252 0.212574397502173 no 739 0.201001378539016 1041 2835149 SGTC_53 0973-0023 39.979 µM 0.838012845146899 0.212584745149134 no 740 0.201011744663661 988 674768 SGTC_544 k015-0020 52.4 µM 0.83791354361944 0.212612581494125 no 741 0.201039630844684 962 3008304 SGTC_481 bay k-8644 50 µM 0.837863649205999 0.212626568770299 no 742 0.201053643233562 926 2303 A calcium channel antagonist. SGTC_1408 3909-7976 48.8 µM 0.837570165581005 0.212708854118338 no 743 0.201136077277221 1022 24152374 SGTC_1240 0356-0016 42.1 µM 0.836993358673174 0.212870630282301 no 744 0.201298150568801 952 4305613 SGTC_1018 4259-0013 28.1 µM 0.836759866005726 0.212936138031861 no 745 0.201363780437496 979 6801262 SGTC_819 1013-0258 27.7 µM 0.836647578009122 0.212967645282338 no 746 0.201395346793708 983 5753198 SGTC_891 0929-0073 133 µM 0.836243706497256 0.213080991375976 no 747 0.201508907505092 1009 5603632 SGTC_62 0180-0423 3.232 µM 0.835851015446652 0.213191233421607 no 748 0.201619361272829 979 30102 YGL099W LSG1 SGTC_308 4092-1169 104 µM 0.834584510097902 0.213547012120496 no 749 0.201975843285644 1014 2268590 YDL196W YDL196W SGTC_1453 4237-0541 195 µM 0.834496443090033 0.213571764207778 no 750 0.202000645440555 1011 739892 SGTC_595 3909-8003 73.7 µM 0.833849464604904 0.213753655035175 no 751 0.202182908722108 1004 699517 SGTC_2129 girgensonine 121.053 µM 0.833155876034269 0.213948749942951 no 752 0.202378411982594 1034 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2914 7968218 45.32 µM 0.831666636331124 0.214367998325241 no 753 0.202798568873404 929 2977111 SGTC_2482 5981709 142.65 µM 0.830906645970221 0.214582133597508 no 754 0.203013184462398 982 877755 SGTC_1605 st000082 49.1 µM 0.830747986635051 0.214626853215932 no 755 0.203058005777478 1005 1114022 SGTC_105 0111-0055 734.78 µM 0.827471609566451 0.21555154096994 no 756 0.203984903601218 895 5179370 SGTC_2715 st079500 56.4 µM 0.823687797676218 0.216622310856962 no 757 0.20505848728709 961 28246688 SGTC_2470 5664817 21.68 µM 0.823644700362368 0.216634524535785 no 758 0.205070734631044 1004 2859561 SGTC_3055 9094636 49.47 µM 0.823516610595003 0.216670827230049 no 759 0.205107137596656 990 25236176 SGTC_1464 k208-0027 110 µM 0.819610237367522 0.217779644841374 no 760 0.206219167859849 1015 X1464 SGTC_764 1951-2361 146 µM 0.818757193145802 0.218022214751596 no 761 0.206462479201808 951 5438930 SGTC_781 4335-2806 94.4 µM 0.818687337056587 0.218042085783831 no 762 0.206482411583911 1096 845254 SGTC_409 arachidonic acid 100 µM 0.81850834316635 0.218093006558903 no 763 0.206533489995132 1030 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_728 3030-5151 22.5 µM 0.817071192643916 0.218502100285779 no 764 0.206943872233599 968 3125388 SGTC_1355 1499-0035 1.68 µM 0.815625559954564 0.218914053957377 no 765 0.207357163030548 995 1548538 SGTC_730 1436-0052 41.2 µM 0.815224015256652 0.219028559088754 no 766 0.207472046870087 1013 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_3353 9151644 39.2805 µM 0.81454239717233 0.219223009236269 no 767 0.207667147143247 996 4909158 SGTC_1265 0819-1001 68.8 µM 0.814461342809066 0.219246138803798 no 768 0.207690354629259 1003 3106768 SGTC_1726 st035556 14.5795 µM 0.814287793267527 0.219295667391693 no 769 0.207740050487701 1038 5919439 SGTC_2311 7694451 200 µM 0.813636305861133 0.219481650063724 no 770 0.207926666373552 977 2163142 SGTC_2264 7948757 110.76 µM 0.813623757657082 0.21948523313809 no 771 0.207930261726287 1041 2971411 SGTC_2657 nystatin 74.44 µM 0.813331510719586 0.219568692234515 no 772 0.208014007663293 1054 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_326 k292-0812 17.5 µM 0.812664636733737 0.219759204553457 no 773 0.208205180825908 1025 3579357 SGTC_995 3931-2021 34.6 µM 0.809640407690921 0.220624355276929 no 774 0.209073438565338 982 730143 SGTC_2815 7968870 71.43 µM 0.809390126619104 0.220696041285387 no 775 0.209145389797296 1042 2977326 YHR190W ERG9 SGTC_2932 9016711 44.54 µM 0.808646761851168 0.220909035959638 no 776 0.209359179514253 1056 7117328 SGTC_3034 9090421 49.47 µM 0.807494657451595 0.221239378317778 no 777 0.209690775651209 991 17173761 SGTC_262 fenpropimorph 62.5 µM 0.805645148788969 0.221770277531484 no 778 0.210223742490868 953 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2041 5107442 45.335 µM 0.804249329560568 0.222171427175751 no 779 0.210626497392212 1042 793005 SGTC_1520 flindersine 88 µM 0.803852833240226 0.22228545319679 no 780 0.210740986438683 1070 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2698 st077697 67.5 µM 0.800844319993738 0.22315174076505 no 781 0.211610888829525 977 3154499 SGTC_1567 st069303 68.4 µM 0.799398116395253 0.223568851547517 no 782 0.212029801153558 1048 5581319 SGTC_3189 9110682 49.47 µM 0.797903602737893 0.224000361317804 no 783 0.212463216264894 1028 17122418 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.796220378309612 0.224486923479408 no 784 0.21295197747671 935 88881 An O-methylated flavonoid and antioxidant. SGTC_1839 st053978 48 µM 0.795653242608787 0.224650997838625 no 785 0.213116805453495 1074 3788398 SGTC_474 dl-dihydrosphingosine 5 µM 0.794533978649331 0.22497500435381 no 786 0.213442318027904 1083 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1743 st037606 46.3785 µM 0.791901582185714 0.22573807815693 no 787 0.214209032180364 1024 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_353 1988-1175 58.3 µM 0.791190197960333 0.225944543802569 no 788 0.214416505281065 959 2788357 SGTC_1390 3413-2614 145 µM 0.789514262015988 0.226431373923396 no 789 0.214905748702564 1113 3421432 SGTC_1893 st059353 36.1 µM 0.78878490329548 0.226643424738937 no 790 0.215118867258081 1018 3112488 SGTC_2832 7992762 51.95 µM 0.787193337051403 0.227106539215973 no 791 0.215584348532716 947 2985177 SGTC_809 3998-0021 90 µM 0.7869572596916 0.227175278490745 no 792 0.215653443179026 1033 715485 SGTC_2229 7354935 190 µM 0.786523822685452 0.227301514026061 no 793 0.215780334070552 1027 318112 SGTC_1066 ketoconazole 628 nM 0.786014653565416 0.227449856491503 no 794 0.215929451188849 1099 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_343 4130-2827 29.8 µM 0.784706260137046 0.227831296738075 no 795 0.216312905772893 1059 1118244 SGTC_2802 7925815 54.55 µM 0.783918052630629 0.228061259104098 no 796 0.216544098126985 1040 1262923 SGTC_2982 9019404 25.97 µM 0.783639150694357 0.228142661000728 no 797 0.216625938219696 992 22333232 SGTC_1231 0242-0792 125 µM 0.783600300080005 0.228154001456996 no 798 0.216637339839346 1058 3707635 SGTC_636 0kpi-0074 126 µM 0.782349852617641 0.228519175076772 no 799 0.21700449817695 1027 616434 SGTC_2565 isoliquiritigenin 100 µM 0.780954032066572 0.228927190156592 no 800 0.217414765635814 956 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2223 6903751 107.57 µM 0.78063969196973 0.229019131901786 no 801 0.217507219994769 1010 5598863 SGTC_1871 st057448 67.3 µM 0.780153871229609 0.229161270987181 no 802 0.217650155226537 1100 691747 SGTC_2257 7960413 200 µM 0.780127897996635 0.229168871503221 no 803 0.217657798439606 1087 2974689 YIL048W NEO1 SGTC_456 gingerol 170 µM 0.779704973856135 0.22929265117882 no 804 0.217782275253708 1147 442793 A herb. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.777875149999088 0.229828628099262 no 805 0.218321309669383 1141 368090 SGTC_2797 7859098 81.82 µM 0.776957080632109 0.230097805445307 no 806 0.218592046297307 1087 972681 SGTC_153 4077-0274 519.67 µM 0.776951419263496 0.230099465901969 no 807 0.218593716421818 1043 3121976 SGTC_1295 1013-0063 9.78 µM 0.776202545709566 0.230319166592992 no 808 0.218814701615436 1091 6826038 SGTC_2406 ethylparaben 405.7 µM 0.775207413733224 0.230611294739225 no 809 0.219108554047767 968 8434 A possible steroid mimic. SGTC_1728 st035614 33.7865 µM 0.774590605533254 0.230792467105251 no 810 0.219290805135537 1062 15945546 SGTC_3216 9129716 49.47 µM 0.771314657420665 0.231756028097359 no 811 0.220260223248294 1041 8056934 SGTC_1645 Cervolide 78 µM 0.769820139982639 0.232196356806245 no 812 0.220703295574286 1029 23173 A fragrance. SGTC_1326 1431-2094 10.8 µM 0.769280143397559 0.232355570080889 no 813 0.220863511199759 1079 616278 SGTC_2595 hexamethylquercetagetin 100 µM 0.765987808094844 0.233327599112392 no 814 0.22184177829018 1023 386331 SGTC_2974 9094440 9.66 µM 0.763650867712447 0.234018924321559 no 815 0.222537663616992 1093 25236134 SGTC_1305 1181-0477 144 µM 0.763093161413779 0.234184075276381 no 816 0.222703919077211 1078 6252086 SGTC_3101 9120531 49.47 µM 0.760528269441873 0.234944434926418 no 817 0.223469438975953 1102 24824904 SGTC_3348 9149464 3.537 µM 0.759752344867941 0.235174725467018 no 818 0.22370131668809 1115 1951442 SGTC_1884 5633444 25 µM 0.759080744210368 0.235374153791765 no 819 0.223902128582083 1083 5724239 SGTC_1137 ixabepilone 100 µM 0.758602355958101 0.235516265603705 no 820 0.224045231468891 1090 154225 A novel microtubule stabilizer. SGTC_359 0081-0058 15.9 µM 0.757958098528289 0.235707725923623 no 821 0.224238033783993 1074 3494159 SGTC_497 capsazepine 133 µM 0.755334937398099 0.23648816205637 no 822 0.2250240204087 1105 2733484 A calcium channel blocker. SGTC_1672 st016598 6.51 µM 0.754862780021354 0.236628787974728 no 823 0.225165660132172 1038 4665860 YNL267W PIK1 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.754430882564136 0.236757463278605 no 824 0.225295266735727 1084 390807 SGTC_2776 terbinafine 19.92 µM 0.753898123186041 0.236916241394215 no 825 0.225455198825626 1130 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_76 0433-0009 400.328 µM 0.753065898777879 0.237164386079755 no 826 0.225705157601981 984 2841569 SGTC_3065 9113888 49.47 µM 0.752011950677536 0.237478847017776 no 827 0.226021936015139 1102 16648368 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.751725315758936 0.237564408337251 no 828 0.22610813148219 1128 688788 SGTC_2059 5238311 157 µM 0.748874426220343 0.238416327040008 no 829 0.2269664478117 1116 703021 SGTC_3069 9117009 49.47 µM 0.747960816720433 0.238689690446243 no 830 0.227241896185638 1001 41904981 SGTC_3204 9114183 49.47 µM 0.746068792583452 0.239256352719209 no 831 0.227812929954978 1114 17027248 SGTC_2628 lathosterol 100 µM 0.745255399058627 0.239500190254646 no 832 0.228058669080233 1172 6710616 SGTC_416 estradiol valerate 100 µM 0.744437058862013 0.239745647555947 no 833 0.228306053044394 1133 13791 A steroid. SGTC_473 2-arachidonoylglycerol 10 µM 0.744251652211606 0.23980127847706 no 834 0.228362122361426 1051 5282280 An endocannabinoid. SGTC_3173 9105693 49.47 µM 0.743620691223202 0.239990649902862 no 835 0.228552990913329 1172 17096658 SGTC_776 4476-4378 112 µM 0.741764990471388 0.24054807691865 no 836 0.229114867788194 1064 2892008 SGTC_1208 2323-2347 50.3 µM 0.741458839306816 0.24064010822155 no 837 0.229207639923696 1125 5412760 SGTC_1026 k007-1105 30.6 µM 0.740925960163941 0.240800341334468 no 838 0.22936916703887 1113 7066794 SGTC_2765 myclobutanil 7.74 µM 0.738748007178491 0.241455840007 no 839 0.230030014281858 1130 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2519 cryptotanshinone 88.04 µM 0.738293626473172 0.241592717093623 no 840 0.23016801934433 1118 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_331 k048-0133 24.5 µM 0.734172362086929 0.242836123592749 no 841 0.231421847803468 1128 6813582 SGTC_1933 st074711 15.9 µM 0.733725458167193 0.242971164604475 no 842 0.231558039658237 1167 17250958 SGTC_82 0054-0107 293.755 µM 0.732411153513805 0.243368543505227 no 843 0.231958826567232 1137 3104697 SGTC_708 3448-5400 146 µM 0.731621834378623 0.243607362164403 no 844 0.232199708787317 1150 3462195 SGTC_529 4076-0302 30.3 µM 0.729980385489286 0.24410440862945 no 845 0.232701087075924 1086 5816522 SGTC_1436 4092-1007 8.32 µM 0.729136991405097 0.244360008993968 no 846 0.232958934450905 1121 2881121 SGTC_2502 avocadyne acetate 18.59 µM 0.724987913877443 0.245619532559899 no 847 0.234229722540119 1170 3952079 SGTC_855 0428-0020 25 µM 0.723421843823536 0.246095844795522 no 848 0.234710377500578 1123 6812414 SGTC_1175 0741-0056 27.6 µM 0.722408707634104 0.246404248745973 no 849 0.235021617443493 1215 765927 SGTC_597 k018-0003 82.8 µM 0.72219005628903 0.246470834522498 no 850 0.235088818011288 1240 6786234 SGTC_717 1532-0246 73.2 µM 0.722053633553181 0.246512384148831 no 851 0.235130751715649 1142 9561992 SGTC_1597 7-benzyloxygramine 47.5 µM 0.721140910021065 0.24679046454783 no 852 0.235411411487941 1169 260807 SGTC_2593 nobiletin 86.24 µM 0.720122535169792 0.247100931955403 no 853 0.235724776836869 1119 72344 An anti-infammatory. SGTC_2510 benzyl isothiocyanate 8.31 µM 0.715509310273504 0.248509958219425 no 854 0.237147194983717 1145 2346 DNA damaging agent; causes G2/M arrest. SGTC_2489 cantharidin 73.42 µM 0.715071416855785 0.248643926974829 no 855 0.237282457418536 1178 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_370 0180-0345 38.7 µM 0.714461953935963 0.248830449572727 no 856 0.237470787064244 1100 3989527 SGTC_3214 9129694 49.47 µM 0.712981264289829 0.249283916206599 no 857 0.237928675419995 1136 17158655 SGTC_574 1315-0397 40 µM 0.712713998907375 0.249365813997194 no 858 0.238011376089612 1223 6794277 SGTC_2687 chenodiol 100 µM 0.709857773812981 0.250241935834489 no 859 0.238896169008527 1158 5702181 A cholesterol synthesis inhibitor. SGTC_2012 4023501 200 µM 0.709048681425283 0.250490414132001 no 860 0.239147133791541 1149 3477460 SGTC_905 2-aminofluorene 215 µM 0.708647666682061 0.250613617187459 no 861 0.239271574179455 1228 1539 An established DNA mutagen. YPR165W RHO1 SGTC_13 0199-0087 65 µM 0.70710215272232 0.251088742819 no 862 0.239751499143745 1196 4589825 SGTC_392 N-ethylmaleimide 8.33 µM 0.707006153129125 0.251118270956508 no 863 0.239781326997089 1141 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2403 6032726 181.2 µM 0.704540931451516 0.251877167611024 no 864 0.240547984534694 1185 2881040 SGTC_1943 st076331 65.2 µM 0.70403500081014 0.252033063458777 no 865 0.240705488444058 1244 24208415 SGTC_931 2812-0076 566 µM 0.703168428472551 0.252300204516576 no 866 0.240975395956214 1222 3450959 SGTC_3203 9113543 49.47 µM 0.702853133171558 0.252397438645216 no 867 0.241073640434535 1189 17018012 SGTC_844 0330-0132 15.3 µM 0.702589672696575 0.252478702542105 no 868 0.241155750132798 1195 2828079 SGTC_1089 terbinafine 2.25 µM 0.7024813310972 0.252512124308529 no 869 0.241189520124663 1171 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_253 dyclonine 31.25 µM 0.701943564171398 0.25267805187506 no 870 0.241357179692696 1236 3180 An oral anasthetic. SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.701338950843685 0.252864673397585 no 871 0.241545755551121 1204 229346 A bile salt which induces apoptosis. SGTC_1085 doxorubicin 7.67 µM 0.701199783227897 0.252907639505574 no 872 0.241589172555896 1213 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.698983497733847 0.25359240501885 no 873 0.242281171951721 1219 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_7 0192-1582 4.227 µM 0.697633292034596 0.254010054847032 no 874 0.242703277902337 1228 252616 SGTC_3105 9121040 49.47 µM 0.697573667352127 0.254028506456119 no 875 0.24272192714958 1051 41448907 SGTC_2030 5175110 200 µM 0.697449003282659 0.254067087594883 no 876 0.242760921747061 1223 2831986 SGTC_3025 9087895 49.47 µM 0.696441528843448 0.254378994377512 no 877 0.243076181532966 1213 17173641 SGTC_736 0958-0254 92.6 µM 0.694749203107678 0.254903377511173 no 878 0.243606243535431 1228 6812352 SGTC_2248 tofa 1.1 µM 0.691599643329023 0.255880802456658 no 879 0.244594392866184 1142 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2094 5332512 191.667 µM 0.690863099704795 0.256109661063743 no 880 0.244825788631998 1230 755774 SGTC_3162 9099653 49.47 µM 0.690787114556409 0.256133277218728 no 881 0.24484966716149 1181 25237511 SGTC_1407 3909-7909 12.3 µM 0.690736188077765 0.256149105784371 no 882 0.244865671640716 1218 4411780 SGTC_2269 7935389 174.42 µM 0.690499014113852 0.256222829040647 no 883 0.244940214855909 1149 97605 SGTC_2828 7998861 71.43 µM 0.690416297126027 0.256248543426147 no 884 0.244966215480892 1132 2988188 SGTC_2357 9067248 200 µM 0.689713768669095 0.256466993993123 no 885 0.245187102752837 1197 9150235 SGTC_2366 9070441 60.58 µM 0.688788898905334 0.256754729256782 no 886 0.245478061262692 1219 6837235 SGTC_2233 sulbentine 40.3845 µM 0.687807470656898 0.257060244046678 no 887 0.245787015497078 1200 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2625 euphol 100 µM 0.687275535846189 0.257225912258254 no 888 0.245954556103252 1195 6708538 A triterpene alcohol. SGTC_197 4544-0043 41.561 µM 0.68353280029193 0.258393134219541 no 889 0.247135115623975 1215 896523 SGTC_232 clozapine 119 µM 0.682423029453408 0.258739757769891 no 890 0.247485748887689 1174 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_146 3448-8650 53.125 µM 0.682142870263266 0.258827300148723 no 891 0.247574307483373 1224 2891488 YIL048W NEO1 SGTC_3302 9125395 16.351 µM 0.68185175308995 0.258918282843883 no 892 0.247666347840189 1191 17599668 SGTC_214 4373-3496 70 µM 0.681793074936224 0.25893662349931 no 893 0.247684901889445 1290 3779166 SGTC_3060 1327-0027 12.5 µM 0.681457345687237 0.259041573165763 no 894 0.247791073847889 1148 16000455 YPR107C YTH1 SGTC_1093 fluphenazine 7.97 µM 0.678623911622047 0.259928186011221 no 895 0.248688094032596 1272 6602611 An atypical antipsychotic. SGTC_2429 5902844 64.44 µM 0.678004321196289 0.260122271051169 no 896 0.24888447669087 1240 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.677314887440665 0.260338322106501 no 897 0.249103093573418 1223 688667 SGTC_2368 9071271 200 µM 0.677019512593438 0.260430913372689 no 898 0.249196787088242 1214 27209959 SGTC_2177 5811945 192 µM 0.676554608916706 0.260576681253587 no 899 0.249344293454575 1255 5343475 SGTC_2532 xanthone 78.9 µM 0.675671785066677 0.26085360117295 no 900 0.249624526794208 1141 7020 An insecticide. SGTC_2899 9053889 58.44 µM 0.675491869523163 0.26091005477441 no 901 0.249681657607101 1195 6470052 SGTC_375 3970-0961 9.27 µM 0.675029071508226 0.261055299634366 no 902 0.249828647498215 1192 2898222 SGTC_2278 7948257 134.34 µM 0.674633740994842 0.261179403356218 no 903 0.249954245319521 1200 1247028 SGTC_2148 5546263 113.568 µM 0.674287570891838 0.261288099339864 no 904 0.250064252226802 1219 792097 SGTC_1698 5-fluorocytosine 1.055 µM 0.670442449916606 0.262497012210666 no 905 0.251287890780368 1256 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2976 9009005 19.48 µM 0.669916309810355 0.26266265401387 no 906 0.25145557101473 1261 2993148 SGTC_2962 9082311 13.18 µM 0.667861686706213 0.263310011534925 no 907 0.252110942894175 1224 16459453 SGTC_2963 9082507 9 µM 0.66757395987118 0.263400731662135 no 908 0.252202792218898 1251 16459611 SGTC_593 1203-0218 61.7 µM 0.666211103658169 0.263830656235272 no 909 0.252638088337743 1268 3666956 SGTC_502 l-744,832 89.3 µM 0.666017291329048 0.263891825027343 no 910 0.252700024097755 1206 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_561 1550-0330 72.9 µM 0.665708846562002 0.263989187681662 no 911 0.252798608932258 1207 6812934 SGTC_1210 3013-0140 750 nM 0.664967408539424 0.264223302424318 no 912 0.253035669487602 1264 905973 SGTC_1813 st051246 8.6015 µM 0.664882762971338 0.264250036634818 no 913 0.25306274071741 1197 5291959 SGTC_2260 7964312 200 µM 0.663843155458648 0.264578495565857 no 914 0.253395350806436 1282 231951 SGTC_3242 9133940 49.47 µM 0.662502320770665 0.265002432231564 no 915 0.253824673993475 1289 17248444 SGTC_491 tetrandrine 80.3 µM 0.662121848959997 0.265122790242848 no 916 0.253946567151131 1252 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1101 ebselen 5.29 µM 0.659543174749389 0.265939256146976 no 917 0.254773515453107 1308 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2340 7987427 183.45 µM 0.65947202732429 0.265961801058138 no 918 0.254796351503912 1232 2239331 SGTC_281 1672-3440 14.9 µM 0.657718967278437 0.266517609388888 no 919 0.255359366079689 1254 6833000 SGTC_2544 sphondin 68.51 µM 0.656054303960053 0.267045934738354 no 920 0.255894592324988 1287 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1971 st069429 63.5 µM 0.655807861311664 0.267124194810699 no 921 0.255973878832988 1252 1246522 YGL099W LSG1 SGTC_772 k072-0172 35.3 µM 0.655097778875541 0.267349752577922 no 922 0.256202401024912 1185 5861980 SGTC_3277 9138724 49.47 µM 0.654733762476176 0.267465419671619 no 923 0.25631959178675 1204 15943418 SGTC_2226 7298446 200 µM 0.653773437581878 0.267770686299022 no 924 0.256628891025043 1254 3283010 SGTC_1773 st048542 73.5835 µM 0.652118290826527 0.268297233537336 no 925 0.257162432713076 1200 3237138 SGTC_430 0958-0115 16.4 µM 0.650966877909557 0.268663836274307 no 926 0.257533934121768 1266 6833180 SGTC_2792 7535235 81.82 µM 0.650331264077644 0.268866319549171 no 927 0.257739133184704 1229 1281891 SGTC_2262 9014885 67.46 µM 0.649892601147806 0.269006106163317 no 928 0.257880798877277 1211 6457424 SGTC_108 0509-0257 621.132 µM 0.649870197895062 0.269013246279527 no 929 0.257888035066448 1251 536624 SGTC_2192 5915882 198.485 µM 0.64933555205798 0.2691836708882 no 930 0.258060755458011 1215 2876149 SGTC_1705 st027868 56.3335 µM 0.647948690180653 0.269626001647863 no 931 0.258509068593467 1279 292948 SGTC_780 0109-0199 192 µM 0.647917550236964 0.269635937712899 no 932 0.258519139433884 1299 610414 SGTC_2288 7946289 167.31 µM 0.645691334747115 0.270346748644673 no 933 0.259239636747032 1320 1246052 SGTC_1414 3917-0015 5.4 µM 0.645478592807885 0.270414724266577 no 934 0.259308543306157 1252 6618702 SGTC_2788 5282734 71.43 µM 0.644490741861903 0.27073047575271 no 935 0.259628629608571 1335 743706 SGTC_2179 6298986 200 µM 0.641035397282084 0.271836369958347 no 936 0.260749842657903 1259 738374 SGTC_208 k072-0098 12.366 µM 0.640924334411851 0.271871953239372 no 937 0.260785922355429 1275 5948901 SGTC_16 erodoxin 22.806 µM 0.640792694582039 0.271914132145249 no 938 0.260828689975669 1299 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_487 nimodipine 119 µM 0.640368207700724 0.272050164761555 no 939 0.260966623368308 1184 4497 L-type voltage-gated calcium channels inhibitor SGTC_2851 9015922 71.43 µM 0.639758331188994 0.272245667232297 no 940 0.261164863178435 1292 2996893 SGTC_1435 4092-0789 56.7 µM 0.63900243201188 0.272488075689967 no 941 0.261410674884467 1321 2248285 SGTC_893 0958-0369 48.9 µM 0.63868908314762 0.272588594599397 no 942 0.261512607979349 1304 6819948 SGTC_824 1304-0008 100 µM 0.63804460968346 0.272795392525187 no 943 0.261722320782367 1285 768245 SGTC_783 0848-0141 92.7 µM 0.637951730499024 0.272825201909398 no 944 0.261752550945059 1273 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1899 st063254 59.6 µM 0.637817360407388 0.272868330574899 no 945 0.261796288669558 1234 3093813 SGTC_1494 4358-1428 177 µM 0.637767462080531 0.272884347263653 no 946 0.261812531625902 1339 1564571 SGTC_42 0133-0086 60.653 µM 0.636937347970387 0.273150871056736 no 947 0.262082827064847 1242 162923 Model of phenazepam hydroxylation. SGTC_477 mead ethanolamide 10 µM 0.636527622604016 0.27328246864387 no 948 0.262216291418835 1175 16061185 SGTC_2299 7976368 114.88 µM 0.635647354253772 0.273565303685534 no 949 0.262503148640232 1295 2979718 SGTC_691 1548-0686 185 µM 0.635613415071823 0.27357621143021 no 950 0.262514211777673 1246 46495133 SGTC_1853 st056710 91.2 µM 0.635496136488463 0.273613905357998 no 951 0.262552442853526 1403 269167 SGTC_2786 7743617 45.45 µM 0.634978565438159 0.273780285991599 no 952 0.262721197358425 1211 583674 SGTC_1572 epiandrosterone 68.9 µM 0.633589151984342 0.27422718016501 no 953 0.263174491109936 1239 441302 A steroid. SGTC_3099 9120367 49.47 µM 0.63351239249677 0.274251879762156 no 954 0.263199545402471 1302 24824940 SGTC_1239 0337-0584 35.4 µM 0.632844288844756 0.274466907921956 no 955 0.263417665840726 1352 914301 YML130C ERO1 SGTC_3128 9127691 49.47 µM 0.631262499019198 0.274976336042685 no 956 0.263934451365983 1296 41316314 SGTC_1286 0929-0070 131 µM 0.630607770777318 0.275187332766631 no 957 0.264148508323336 1357 1420408 SGTC_1394 3474-0001 65.7 µM 0.629902620520852 0.275414667920367 no 958 0.26437914913173 1236 5017666 YIL048W NEO1 SGTC_154 3389-1638 511.116 µM 0.629227797133451 0.27563231240849 no 959 0.264599966569701 1206 5238686 SGTC_3075 9116269 49.47 µM 0.628239552240458 0.27595119432656 no 960 0.264923511812994 1324 17015205 YNL244C SUI1 SGTC_3284 9108171 64.8615 µM 0.627928338910337 0.276051652589971 no 961 0.265025442737074 1282 8687505 SGTC_1112 tnp00069 1.16933 µM 0.627342711594598 0.276240739127729 no 962 0.265217305797218 1371 145826 SGTC_1172 0370-0043 85 µM 0.626695653699663 0.27644973416468 no 963 0.265429376707483 1345 376585 SGTC_479 n-linoleoylglycine 10 µM 0.624729135977132 0.277085380737168 no 964 0.266074423571969 1297 6433346 An anti-infammatory. SGTC_2354 9060492 162 µM 0.6233203888703 0.277541175846261 no 965 0.266537001009707 1318 6471895 SGTC_2171 5739187 198.077 µM 0.623197704484482 0.277580887279131 no 966 0.266577305006315 1256 2262761 SGTC_734 2023-0417 80 µM 0.619009954125916 0.278938073031113 no 967 0.267954900683923 1314 3935732 SGTC_2627 acetyl isogambogic acid 100 µM 0.618943199940888 0.278959733152278 no 968 0.267976889027105 1259 6857789 A caspase activator and apoptosis inducer. SGTC_2430 5571206 200 µM 0.618624434915024 0.279063175986368 no 969 0.26808190043524 1343 1731771 SGTC_3076 9116187 49.47 µM 0.618507591845643 0.279101097546928 no 970 0.268120397471463 1303 27241210 SGTC_629 3448-6466 76.7 µM 0.617707916874353 0.279360700266556 no 971 0.268383946182246 1300 573744 SGTC_798 1287-0182 476 µM 0.616803633374176 0.279654403862568 no 972 0.268682127579628 1343 1649755 SGTC_2839 9003951 25.97 µM 0.61367729963026 0.280670963647926 no 973 0.269714295934249 1324 2990634 SGTC_1281 0884-0031 11.8 µM 0.611614829068203 0.281342574470044 no 974 0.270396312263789 1323 1548255 SGTC_631 k072-0230 41.5 µM 0.611595917275517 0.281348736382625 no 975 0.270402569988032 1355 5773147 SGTC_2652 actinonin 100 µM 0.611580376750588 0.281353799904616 no 976 0.270407712247457 1299 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1096 rimcazole 32.2 µM 0.609788984111101 0.281937778489335 no 977 0.271000799841047 1266 18528119 A dopamine reuptake inhibitor. SGTC_424 splitomicin 100 mM 0.609635505444867 0.281987838357824 no 978 0.271051643150042 1284 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3338 9144300 39.5675 µM 0.608325708411821 0.282415226644814 no 979 0.271485736758962 1329 4901274 SGTC_2789 5281112 71.43 µM 0.608147616087479 0.282473362428738 no 980 0.271544786941815 1307 765948 SGTC_2859 9028643 45.46 µM 0.607259395897249 0.282763395558079 no 981 0.271839390135492 1280 17151580 SGTC_206 4546-0025 72.014 µM 0.606451566760938 0.283027302530556 no 982 0.272107467398349 1336 6620745 YIL048W NEO1 SGTC_1985 st071382 65.5 µM 0.605797130029759 0.283241184905266 no 983 0.272324737873338 1340 6123237 SGTC_3028 9087778 49.47 µM 0.603726715490654 0.283918345909852 no 984 0.273012674683862 1273 17217395 SGTC_1440 4100-1550 40 µM 0.603428085905041 0.284016081221238 no 985 0.27311197140854 1338 742806 SGTC_796 1234-0020 70.7 µM 0.603425981811462 0.284016769904823 no 986 0.273112671099971 1285 46495034 SGTC_2337 9009472 200 µM 0.601958432213992 0.284497302982853 no 987 0.273600903640504 1410 5742383 SGTC_1459 k035-0031 35.7 µM 0.600773822098664 0.284885473659523 no 988 0.273995321065531 1228 3877128 YMR208W ERG12 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.599416341011445 0.28533060075799 no 989 0.274447641332359 1324 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_640 3381-0960 37.1 µM 0.596710503565184 0.286218849885043 no 990 0.275350339351235 1409 1745025 SGTC_1314 1222-0010 41.1 µM 0.59611672478669 0.286413946057826 no 991 0.275548625995274 1350 3526027 SGTC_2499 avocadenofuran 51.48 µM 0.594859431932104 0.286827259307915 no 992 0.275968718341466 1286 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_687 k029-0044 34.9 µM 0.594670907134673 0.286889257932035 no 993 0.27603173620359 1385 5829338 SGTC_1614 st002383 48.6 µM 0.593517460860875 0.287268720679375 no 994 0.276417450519431 1358 1947235 SGTC_144 4161-2749 112.381 µM 0.593132108851548 0.28739554735892 no 995 0.276546371741879 1275 797501 YMR168C CEP3 SGTC_1220 1838-0075 193 µM 0.592190175452956 0.287705667010122 no 996 0.2768616237668 1288 5529645 SGTC_1634 st006576 41 µM 0.591078397384737 0.288071909205707 no 997 0.277233946762233 1378 3915356 SGTC_2484 5809818 12.04 µM 0.589634430915424 0.288547909178034 no 998 0.277717881549612 1355 2870548 SGTC_2160 5660466 132.927 µM 0.588519858264464 0.288915578529183 no 999 0.278091704327653 1315 2859134 SGTC_867 0518-0118 155 µM 0.58845359797524 0.288937443064978 no 1000 0.278113935465545 1376 6848158 SGTC_2276 7947513 42.08 µM 0.587733002750383 0.289175274963282 no 1001 0.278355759942062 1213 2105100 SGTC_3285 9112818 20.8695 µM 0.584869450901766 0.290121296484105 no 1002 0.279317750578021 1376 17017947 YPR165W RHO1 SGTC_2558 carylophyllene oxide 100 µM 0.583081845227347 0.290712595808172 no 1003 0.279919102300235 1409 6708694 An oxygenated terpenoid and antifungal agent. SGTC_404 fumagillin 50 µM 0.582832060359569 0.290795263823415 no 1004 0.280003180059753 1373 12015870 A methionine aminopeptidase binder. SGTC_476 mead acid 10 µM 0.581549923475601 0.291219768717745 no 1005 0.280434940825358 1393 5312531 An omega 9 fatty acid. SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.581510258234476 0.291232906162598 no 1006 0.280448303269675 1432 1273210 SGTC_1711 st032263 62.8 µM 0.581047401161687 0.291386228571049 no 1007 0.280604253548397 1378 3958979 SGTC_417 st075190 100 µM 0.580737852908482 0.291488788112173 no 1008 0.28070857294656 1435 222757 SGTC_2614 arthonioic acid 13.39 µM 0.579720533096227 0.291825965093468 no 1009 0.281051547169624 1307 6710684 SGTC_2729 fluphenazine 10.66 µM 0.579573268962563 0.29187478886278 no 1010 0.281101211848971 1292 3372 An atypical antipsychotic. SGTC_1623 st003709 20.3 µM 0.57941230079369 0.291928160402963 no 1011 0.281155503049383 1339 16192618 SGTC_2050 5263056 171 µM 0.578990081745278 0.292068175392163 no 1012 0.281297932771981 1367 763468 YGL055W OLE1 SGTC_50 0929-0078 56.389 µM 0.578067301420958 0.292374293744269 no 1013 0.281609341075465 1390 1377751 SGTC_1055 3448-0672 86 µM 0.577699658143104 0.292496295360597 no 1014 0.281733455003632 1363 748378 SGTC_2880 9042983 58.44 µM 0.577450760464259 0.29257890493967 no 1015 0.281817496172769 1374 6464714 SGTC_1811 st050069 61.5 µM 0.576871738660045 0.292771125231202 no 1016 0.282013051636032 1368 3877702 SGTC_969 1313-0238 134 µM 0.57478860361089 0.293463156790319 no 1017 0.282717137578495 1400 5212874 SGTC_3087 9117406 49.47 µM 0.573672330605142 0.29383430176537 no 1018 0.283094777766668 1349 42546093 SGTC_2956 9076196 2.52 µM 0.572752000142541 0.294140461833479 no 1019 0.283406311664581 1405 16423868 SGTC_663 1486-0733 13.9 µM 0.572740104753374 0.294144419956394 no 1020 0.283410339355773 1370 722445 YPR165W RHO1 SGTC_756 0508-1999 28.3 µM 0.571800418125027 0.294457173060108 no 1021 0.283728597001546 1328 6753853 SGTC_881 0833-0569 170 µM 0.571392403011798 0.294593019292678 no 1022 0.283866838818685 1330 5418700 SGTC_1021 4476-0760 85.3 µM 0.570798945877653 0.29479065895204 no 1023 0.2840679687871 1345 746768 SGTC_373 0844-0104 25.9 µM 0.570105293025988 0.295021744350545 no 1024 0.284303142692772 1397 5375804 SGTC_2761 levamisole 97.89 µM 0.569291622228424 0.295292919157983 no 1025 0.284579125657125 1462 26879 An alkaline phosphatase inhibitor. SGTC_2464 5717415 7.67 µM 0.567966618624258 0.295734752892256 no 1026 0.285028817402401 1311 5285744 SGTC_1997 st073024 93.8 µM 0.566153947030401 0.296339695219084 no 1027 0.285644566607747 1358 686268 SGTC_2734 clemastine 41.6 µM 0.565907346841369 0.296422036847991 no 1028 0.285728383492485 1382 26987 Clemastine is a selective histamine H1 antagonist. SGTC_992 3909-8734 162 µM 0.565202679140094 0.296657388391352 no 1029 0.285967957304704 1376 4288319 SGTC_1830 st055982 50.3 µM 0.56452743655029 0.296882992519861 no 1030 0.286197616673446 1384 455313 An antimicrobial agent. SGTC_179 1273-0063 6.77 µM 0.561182000630669 0.298001886565074 no 1031 0.287336735991622 1361 3108139 SGTC_2874 9043904 71.43 µM 0.560666949375093 0.298174318044615 no 1032 0.28751230106225 1372 4463428 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.559787689067753 0.298468786244542 no 1033 0.287812130902404 1442 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3108 9121785 49.47 µM 0.557905788901498 0.299099487245157 no 1034 0.288454359170705 1425 17140271 SGTC_1152 3909-8331 15.9 µM 0.55532408957611 0.29996570217208 no 1035 0.289336502276382 1372 16001939 SGTC_22 0964-0034 14.468 µM 0.552869926643125 0.300790176808923 no 1036 0.290176240801382 1362 138402 SGTC_2074 5212007 75.395 µM 0.551102649648947 0.301384524948912 no 1037 0.290781654585399 1384 758611 SGTC_339 3091-4833 71.4 µM 0.550557634823943 0.301567924013612 no 1038 0.290968478685221 1409 3240077 SGTC_2355 9061122 103.12 µM 0.550404924215039 0.301619320578324 no 1039 0.291020835983034 1441 5302957 SGTC_3231 9132313 49.47 µM 0.549828704189144 0.301813289725519 no 1040 0.291218434401125 1441 4905967 SGTC_960 1222-0186 7.7 µM 0.547801475418961 0.302496147523352 no 1041 0.291914112705608 1471 3126296 SGTC_836 0330-0104 1.35 µM 0.547375614167682 0.30263968389035 no 1042 0.292060352608885 1422 46494820 SGTC_2742 clothiapine 36.27 µM 0.546210345242919 0.30303259323059 no 1043 0.292460677850948 1440 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2014 4013930 200 µM 0.545694504961418 0.303206598861578 no 1044 0.292637974908907 1384 64556 SGTC_2377 9073351 62.6 µM 0.545428103725574 0.303296480050046 no 1045 0.292729557983006 1382 7337946 YHR072W ERG7 SGTC_2275 7947463 200 µM 0.544755195659334 0.303523565708997 no 1046 0.292960948704722 1385 1225414 SGTC_3114 9122766 49.47 µM 0.544734308987912 0.30353061552949 no 1047 0.292968132294798 1362 17176985 SGTC_1068 loratadine 26.9 µM 0.54448398793535 0.303615111392008 no 1048 0.293054232018887 1404 3957 A H1 histamine antagonist. SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.542589216930219 0.304255031552598 no 1049 0.293706332466555 1516 165506 SGTC_1186 1319-0216 26 µM 0.541237136372362 0.304712036046974 no 1050 0.294172071892771 1512 4565136 SGTC_2155 5570423 76 µM 0.54049908514083 0.304961626754838 no 1051 0.294426445870067 1428 797402 SGTC_71 0417-1750 47.813 µM 0.540402339393667 0.304994350509556 no 1052 0.294459797423611 1557 6811472 SGTC_1737 st035557 69.7 µM 0.539818290966758 0.305191935023467 no 1053 0.29466117583516 1387 5716916 SGTC_923 1900-2434 73.3 µM 0.538838378759794 0.305523568431104 no 1054 0.294999189693264 1379 5910570 SGTC_2456 5770359 74.46 µM 0.538756425003399 0.30555131142166 no 1055 0.295027467160825 1495 3118787 SGTC_821 1114-0266 29.2 µM 0.535979902226234 0.306491878906322 no 1056 0.295986220265478 1412 3123235 SGTC_1829 berberine 14.4 µM 0.535408000343995 0.306685773576153 no 1057 0.296183879575947 1508 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2571 chrysanthemic acid 100 µM 0.534709693475543 0.306922597312381 no 1058 0.296425308739932 1369 2743 An insecticide. SGTC_358 0075-0058 9.45 µM 0.533846863434513 0.307215328732542 no 1059 0.296723743854387 1539 1069125 SGTC_2937 9044753 11.33 µM 0.533134592259774 0.307457072815194 no 1060 0.296970207370684 1391 6465530 YGL099W LSG1 SGTC_2122 5258151 111.688 µM 0.532709511543743 0.307601384629846 no 1061 0.297117340464266 1394 2173356 SGTC_1320 1313-0481 95.3 µM 0.53059305352485 0.308320349650439 no 1062 0.297850405200202 1460 6813365 YLR208W SEC13 SGTC_1832 st054113 55 µM 0.529439599324703 0.308712490350865 no 1063 0.298250267063417 1441 1251267 SGTC_2525 harmine 47.85 µM 0.529376482937914 0.308733954377829 no 1064 0.298272154339366 1502 5280953 A monoamine oxidase inhibitor SGTC_3011 9081274 71.4286 µM 0.528059579290186 0.309181943528887 no 1065 0.298728992217344 1426 6625322 SGTC_1642 st009582 77.7 µM 0.527812101966538 0.309266162985139 no 1066 0.298814878342714 1498 6739311 SGTC_2078 5212016 200 µM 0.52595310368916 0.309899122217122 no 1067 0.299460395497097 1435 1899708 SGTC_3137 9097352 49.47 µM 0.525145903106179 0.310174136834889 no 1068 0.299740883933214 1523 44120435 SGTC_699 0375-0592 111 µM 0.524749413150826 0.310309260545706 no 1069 0.299878700992402 1476 762578 SGTC_1232 0279-0259 161 µM 0.524745493881752 0.310310596359809 no 1070 0.299880063445328 1442 1560000 SGTC_1986 st071812 45 µM 0.523244732666053 0.310822288295751 no 1071 0.300401977900175 1459 11838594 SGTC_1031 k035-0009 16 µM 0.523132736586573 0.310860488601468 no 1072 0.300440942833901 1550 5180959 SGTC_2537 larixol 68.93 µM 0.521243552601571 0.311505169943999 no 1073 0.301098558975925 1469 6708759 SGTC_1347 1493-0251 600 nM 0.521129150697915 0.311544228021135 no 1074 0.301138402567514 1508 3986378 SGTC_3253 9135987 49.47 µM 0.519281266756098 0.312175409601121 no 1075 0.301782307491477 1450 4182430 SGTC_2803 7707263 71.43 µM 0.519046386520087 0.312255677183534 no 1076 0.301864197065047 1449 2199229 SGTC_1135 dihydrocapsaicin 536.708 nM 0.518266704270881 0.312522188376079 no 1077 0.302136100125155 1393 107982 A Capsaicinoid. SGTC_2515 chrysin 20.77 µM 0.517804035078359 0.312680384460387 no 1078 0.302297501366978 1515 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2541 muurolladie-3-one 83.07 µM 0.517710561003499 0.312712349355033 no 1079 0.302330114311485 1472 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1215 3852-0577 11.2 µM 0.514886850971526 0.313678623408944 no 1080 0.303316044904529 1566 2884876 SGTC_2453 5731132 22.18 µM 0.513774677967288 0.314059560845463 no 1081 0.303704766892142 1576 1362040 SGTC_2523 spermine 47.74 µM 0.513133771189354 0.314279171943868 no 1082 0.303928874840465 1506 1103 A DNA binding polyamine. SGTC_539 4859-0462 2.54 µM 0.512275481912314 0.314573373635377 no 1083 0.304229111077788 1542 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2680 butyl paraben 22.24 µM 0.510387928651305 0.315220797311328 no 1084 0.304889856086328 1484 7184 An antifungal and steroid mimetic. SGTC_2819 7996655 46.38 µM 0.510191388321946 0.315288242584707 no 1085 0.304958692394896 1487 6456960 SGTC_2421 5690543 90.72 µM 0.509806567823842 0.315420316379901 no 1086 0.305093491959736 1497 3397993 SGTC_1438 4092-1045 4 µM 0.509110947076398 0.315659119412979 no 1087 0.305337229489303 1444 1351342 SGTC_1376 2910-0861 41.3 µM 0.507424161368246 0.316238503825375 no 1088 0.305928618174269 1506 1112859 SGTC_2662 daunorubicin 22.37 µM 0.506683191364973 0.316493158195679 no 1089 0.306188563124185 1431 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3202 9113761 49.47 µM 0.505415378766192 0.316929078051861 no 1090 0.306633559798563 1635 4798415 SGTC_2865 9030313 51.95 µM 0.504184861251787 0.31735241767793 no 1091 0.307065738836691 1426 42562754 SGTC_1513 0337-0559 19 µM 0.503492602860878 0.317590683078033 no 1092 0.307308989877818 1414 775073 SGTC_1056 3448-1962 115 µM 0.503384325425872 0.317627957454314 no 1093 0.3073470449013 1513 715507 SGTC_1064 honokiol 6.76 µM 0.502841009376146 0.31781502125506 no 1094 0.307538029248693 1460 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1492 4158-0558 28.5 µM 0.50147368484404 0.318285997019766 no 1095 0.30801889667978 1568 3967268 SGTC_941 3237-0776 460 µM 0.498349949411376 0.319363071331336 no 1096 0.309118703766948 1567 760008 SGTC_2102 5377816 72.7585 µM 0.497872895529765 0.319527695635867 no 1097 0.30928681626876 1561 1379702 SGTC_3319 9138450 16.7555 µM 0.497296734243649 0.319726567878187 no 1098 0.309489907189563 1466 2029690 SGTC_1164 k060-0068 93.7 µM 0.496181392876816 0.320111694918227 no 1099 0.309883218868903 1513 5963676 SGTC_503 tyrphostin 8 294 µM 0.495880843818151 0.320215507601416 no 1100 0.309989241124042 1540 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2201 6605497 169.863 µM 0.495294307137291 0.320418143829451 no 1101 0.310196194419416 1532 670741 SGTC_1756 st041558 35.5 µM 0.49427577656141 0.32077015217766 no 1102 0.310555715053112 1675 3955792 SGTC_2335 9018011 154.17 µM 0.49420763741654 0.320793707102369 no 1103 0.310579773253159 1593 6458208 SGTC_1949 st076024 69.1 µM 0.493276863926745 0.321115537079157 no 1104 0.310908486797095 1443 2921930 SGTC_3219 9131112 49.47 µM 0.491880040152703 0.321598763633667 no 1105 0.311402074640977 1461 17612988 YMR079W SEC14 SGTC_1304 1165-0502 251 µM 0.490272352966751 0.322155311513664 no 1106 0.311970593999404 1521 767425 SGTC_1968 st069590 43.6 µM 0.489234959902516 0.322514647318481 no 1107 0.312337680782716 1538 6384066 SGTC_846 0335-0850 148 µM 0.487874148227705 0.32298626143938 no 1108 0.312819493387801 1492 6819598 SGTC_658 3253-0951 102 µM 0.487873840440256 0.322986368140974 no 1109 0.312819602400065 1522 1184878 SGTC_1013 4112-3890 241 µM 0.484979245205998 0.323990489404054 no 1110 0.313845534017959 1468 705171 SGTC_229 benomyl 22.8748 µM 0.484708344520722 0.324084529273898 no 1111 0.313941623224083 1475 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2452 5863136 48.41 µM 0.482702815110679 0.324781073213429 no 1112 0.314653382062708 1465 2184096 SGTC_1179 1021-1431 9.29 µM 0.482446352135552 0.324870190084895 no 1113 0.314744450078901 1522 2840958 SGTC_533 1222-0222 6.71 µM 0.482238179398272 0.324942534224474 no 1114 0.31481837889144 1599 3982874 SGTC_1146 3579-1023 7 µM 0.482089574850257 0.324994181279802 no 1115 0.314871157670673 1606 X1146 SGTC_860 0443-0016 25.1 µM 0.481627924075083 0.325154648041886 no 1116 0.315035142880556 1511 5337942 SGTC_1006 4099-6547 255 µM 0.481106582978467 0.325335901759072 no 1117 0.315220374819759 1539 3146833 SGTC_307 1501-1223 22.3 µM 0.480193567923559 0.325653427591731 no 1118 0.315544880020361 1505 2830329 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.479122111075758 0.326026217252704 no 1119 0.315925880315539 1496 2724 A muscle relaxant with antifungal properties. SGTC_2271 7849410 118.62 µM 0.477514885894233 0.326585741729151 no 1120 0.316497761684024 1536 972430 SGTC_1421 4029-0249 71.4 µM 0.475770422341049 0.327193484855363 no 1121 0.317118971956063 1619 2894095 SGTC_961 1252-1571 372 µM 0.475441835224141 0.327308010694548 no 1122 0.317236040881458 1630 6813498 SGTC_2529 gangaleoidin 93.61 µM 0.473463093978033 0.327998025103866 no 1123 0.317941412623154 1547 4565183 SGTC_287 k060-0039 29.6 µM 0.473300850424807 0.328054627763267 no 1124 0.31799927774641 1590 5861974 SGTC_173 1273-0061 2.693 µM 0.473120970631802 0.32811738787554 no 1125 0.318063438133323 1447 2847414 YPL266W DIM1 SGTC_2605 digitonin 300 nM 0.473039913331421 0.328145670377458 no 1126 0.318092351824642 1566 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2991 9074669 71.4286 µM 0.47113605918578 0.328810245939981 no 1127 0.318771788084204 1619 17333109 SGTC_1808 st050063 61.5 µM 0.470127487061074 0.329162526349313 no 1128 0.3191319685402 1576 4011993 SGTC_2128 5255449 168.493 µM 0.470044420673812 0.329191547067035 no 1129 0.319161640758556 1476 736008 SGTC_540 1187-0821 17.3 µM 0.469105983591343 0.329519478192959 no 1130 0.319496941148426 1495 847520 SGTC_1071 trifluoperazine 6.31 µM 0.467781957212854 0.329982374159321 no 1131 0.319970262331817 1608 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.467775533438506 0.329984620625538 no 1132 0.319972559457961 1558 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_328 k915-0120 63.5 µM 0.467226770005865 0.330176552002541 no 1133 0.320168821405947 1600 6624543 SGTC_2743 auranofin 4.32 µM 0.466960793052183 0.330269594189863 no 1134 0.320263964577763 1555 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1194 1488-0194 225 µM 0.465319546411243 0.330843955561382 no 1135 0.320851319590655 1539 1391452 SGTC_2512 diallyl trisulfide 49.23 µM 0.46486128985612 0.331004395640275 no 1136 0.32101539663543 1505 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1090 efavirenz 20.7 µM 0.464196390904772 0.331237238416563 no 1137 0.321253523364449 1571 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_3207 9114163 49.47 µM 0.464137457026091 0.331257879782212 no 1138 0.321274633475346 1710 849233 SGTC_664 1222-0054 14.9 µM 0.464002966043221 0.331304986654642 no 1139 0.321322810297659 1519 6813991 SGTC_2444 5485484 36.41 µM 0.463823433009017 0.331367874136369 no 1140 0.321387126588952 1614 6790631 SGTC_2142 5622915 118.518 µM 0.462732304454414 0.331750180819026 no 1141 0.321778129907309 1510 5322196 SGTC_1554 st069299 38.7 µM 0.462154894776911 0.331952563018005 no 1142 0.321985123210713 1532 24207999 SGTC_2867 9039098 71.43 µM 0.461447139689518 0.332200698198309 no 1143 0.322238918875192 1503 6463460 SGTC_600 1495-0418 41.6 µM 0.460975972694965 0.332365927654207 no 1144 0.322407921795398 1540 5377768 SGTC_110 0850-0284 111.64 µM 0.458831181954878 0.333118477017308 no 1145 0.323177700390737 1442 3906265 SGTC_1550 gossypolone 36.6 µM 0.456670986983541 0.333877111146062 no 1146 0.323953773746663 1532 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1467 k284-1082 293 µM 0.456342187157837 0.333992641292982 no 1147 0.324071965869997 1636 3334705 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.454762550474226 0.334547896257471 no 1148 0.324640037520793 1509 5355888 SGTC_3210 9128157 49.47 µM 0.453746339947122 0.334905293885121 no 1149 0.32500570474654 1502 17590849 SGTC_858 0438-0351 2.77 µM 0.452463258242965 0.335356762786525 no 1150 0.325467642189704 1517 2799119 SGTC_385 1494-0393 12.4 µM 0.452336919311498 0.335401229649246 no 1151 0.325513141482092 1577 3090647 SGTC_127 0180-0333 59.125 µM 0.446717975888394 0.337381224176391 no 1152 0.327539350558723 1547 771601 SGTC_916 4466-0038 42 nM 0.446493679453956 0.337460355401787 no 1153 0.3276203386099 1623 5722064 YGL116W CDC20 SGTC_3261 9137475 49.47 µM 0.444436223341788 0.33818655583465 no 1154 0.328363614589722 1549 17027690 SGTC_547 1120-0019 610 nM 0.440804224633911 0.339469976498117 no 1155 0.329677367421201 1584 3676939 SGTC_335 4077-0256 27.6 µM 0.439201370369349 0.340036962609584 no 1156 0.33025781609724 1645 3121989 SGTC_255 tunicamycin 200.472 nM 0.438884477755515 0.340149101604747 no 1157 0.330372622249975 1650 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2220 6782180 200 µM 0.43872393226045 0.340205919340857 no 1158 0.330430791930249 1591 833803 SGTC_2308 7584454 197.62 µM 0.438664295156674 0.340227026090808 no 1159 0.330452401000184 1663 893577 SGTC_1342 1486-1464 234 µM 0.43829642459606 0.340357233820514 no 1160 0.330585708713263 1560 3253938 SGTC_2443 5493264 126.67 µM 0.437818208107085 0.340526526928838 no 1161 0.330759035350122 1676 5340055 SGTC_2352 9027995 87.8 µM 0.437603496348361 0.340602547354461 no 1162 0.330836868119421 1617 2997347 SGTC_2067 5224629 34.075 µM 0.437491557422656 0.340642182799962 no 1163 0.330877448753658 1536 2835000 SGTC_3151 9099821 49.47 µM 0.436310064192387 0.341060634322655 no 1164 0.331305890434187 1519 17174189 SGTC_1570 verbenone 133 µM 0.435489003028674 0.341351546204817 no 1165 0.331603759748595 1692 29025 A natural terpanoid with antifungal properties. SGTC_3048 9093155 49.47 µM 0.434481049244631 0.341708805327078 no 1166 0.331969576688618 1579 25236002 SGTC_522 1273-0010 11.6 µM 0.434366630265747 0.34174936895761 no 1167 0.332011112932581 1621 5705015 SGTC_2047 4141938 200 µM 0.434310740744278 0.341769183484278 no 1168 0.332031402631829 1591 3807862 SGTC_616 4092-0450 108 µM 0.432694570422071 0.34234235314851 no 1169 0.33261833742757 1610 787165 SGTC_2158 5657123 3.6195 µM 0.429806516990255 0.343367496186797 no 1170 0.333668195924596 1594 2858827 SGTC_939 1165-0479 45.3 µM 0.429510368735595 0.343472682258055 no 1171 0.333775924886883 1595 1377347 SGTC_1885 st057546 99.9 µM 0.428736860358506 0.343747474482171 no 1172 0.3340573663299 1646 702008 SGTC_1118 chelidonine 707.474 nM 0.426864153303237 0.344413103560928 no 1173 0.334739138129242 1715 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_216 k038-0035 28.382 µM 0.424804981017942 0.345145565803963 no 1174 0.335489423148974 1620 4444231 YPR107C YTH1 SGTC_398 bronopol 33.3 µM 0.424643085702403 0.345203177769779 no 1175 0.335548439594313 1621 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_3116 9124943 49.47 µM 0.42390881844804 0.345464518673362 no 1176 0.335816156332832 1503 41905195 YPL160W CDC60 SGTC_333 3486-0131 40.1 µM 0.423037636476887 0.34577468592654 no 1177 0.336133900810614 1709 6744690 SGTC_1178 0988-0033 191 µM 0.420972385818192 0.346510391266449 no 1178 0.336887623178911 1639 5392207 SGTC_357 1325-0123 420 µM 0.420505135848841 0.346676920437261 no 1179 0.337058239156785 1683 1098503 SGTC_622 1348-1566 26.3 µM 0.420261841555788 0.346763642923627 no 1180 0.337147091161661 1682 7340407 SGTC_1870 st057514 26.5 µM 0.418480446859515 0.347398867162119 no 1181 0.337797939828937 1582 5393161 SGTC_2916 7875993 68.79 µM 0.417427490706003 0.347774540626963 no 1182 0.338182875233685 1744 1299250 SGTC_773 4358-1457 44.6 µM 0.416568546020308 0.348081105468665 no 1183 0.338497010065307 1747 1186886 SGTC_1280 0880-0253 10.1 µM 0.416149106871578 0.348230843056224 no 1184 0.338650448986957 1581 6836607 SGTC_90 0870-0863 4.608 µM 0.411744505089822 0.349804687790287 no 1185 0.340263350391481 1584 1738164 SGTC_106 0092-0003 11.579 µM 0.410100237554207 0.350392878574012 no 1186 0.340866209231082 1725 1072148 SGTC_32 0928-0142 34.1 µM 0.409631195557386 0.350560731110603 no 1187 0.341038254703477 1645 2244242 SGTC_1470 k295-0292 231 µM 0.40936152749355 0.350657248409206 no 1188 0.341137184417507 1687 5045612 SGTC_425 3825-7017 13.1 µM 0.407609750794284 0.3512844638931 no 1189 0.341780102238326 1673 3397440 SGTC_1373 2887-0003 58.5 µM 0.407163270477666 0.3514443889633 no 1190 0.341944038038851 1598 776948 SGTC_3224 9130643 49.47 µM 0.407150706718794 0.351448889564727 no 1191 0.34194865155113 1682 17644395 SGTC_3351 9150312 21.596 µM 0.405641516828961 0.351989664319762 no 1192 0.34250300960066 1600 4904905 SGTC_1248 0469-0687 58.6 µM 0.404550145177206 0.352380912615646 no 1193 0.342904105556229 1695 4017482 SGTC_2139 5578692 56.4705 µM 0.403778392435862 0.352657674348183 no 1194 0.343187843558011 1725 650991 YMR113W FOL3 SGTC_225 nsc-122657 1.016 µM 0.403008472790601 0.352933856437622 no 1195 0.343470995731313 1655 275685 SGTC_3243 9134147 49.47 µM 0.402228914939608 0.35321357486988 no 1196 0.343757782060395 1664 24282180 SGTC_1606 st000094 49.2 µM 0.401565819252689 0.353451567163745 no 1197 0.344001794695832 1770 1242210 SGTC_101 0490-5701 117.494 µM 0.401142752873461 0.353603440266282 no 1198 0.344157512889171 1717 4661669 SGTC_1303 1160-0052 261 µM 0.400838932634767 0.353712520562707 no 1199 0.34426935641929 1640 3562476 SGTC_2161 5662504 8.5105 µM 0.400329803322115 0.353895339710544 no 1200 0.344456809687183 1602 2859334 SGTC_163 TUB2.036 7.546 µM 0.399997372614598 0.354014727762891 no 1201 0.344579225977775 1637 15992207 YJR013W GPI14 SGTC_390 dec-rvkr-cmk 16.7 µM 0.399741397022896 0.354106667763047 no 1202 0.344673499069095 1658 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2238 6671620 73.2395 µM 0.398848251055826 0.354427529936299 no 1203 0.345002510760095 1540 729941 SGTC_3070 9117005 49.47 µM 0.397981147326267 0.354739135326251 no 1204 0.345322041319149 1685 8779016 SGTC_340 k038-0059 454 µM 0.396097376297121 0.355416428571804 no 1205 0.346016596885308 1667 23733424 SGTC_1270 0831-1170 17.3 µM 0.389987608028789 0.357616276174612 no 1206 0.348272855129906 1626 6764716 SGTC_1426 4048-4480 71.7 µM 0.389083551283093 0.357942189799332 no 1207 0.348607170438115 1714 14224343 SGTC_1713 st033146 12.748 µM 0.388296540050722 0.358225992702154 no 1208 0.348898298716663 1752 674619 SGTC_3141 9094609 49.47 µM 0.388229959787335 0.358250005704459 no 1209 0.348922931925348 1585 25236309 YDL196W YDL196W SGTC_3064 1327-0027 10 µM 0.387732772274567 0.358429340301092 no 1210 0.349106900312164 1605 16000455 YPR107C YTH1 SGTC_1664 st014217 9.02 µM 0.386472736883048 0.358883972463955 no 1211 0.349573294991631 1698 3982782 SGTC_3018 9082602 49.47 µM 0.386115347603604 0.35901295817965 no 1212 0.349705621911324 1657 17332089 SGTC_217 ketoconazole 989 nM 0.383577579401588 0.359929328168528 no 1213 0.350645780103919 1633 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1824 st053723 68.6 µM 0.383146145534821 0.360085196128222 no 1214 0.350805703117863 1598 675225 SGTC_1247 0448-0043 5.84 µM 0.382172557352885 0.360437018461479 no 1215 0.351166687879727 1647 3089013 YGL099W LSG1 SGTC_252 miconazole 1.30953 nM 0.381265062992499 0.360765063132978 no 1216 0.351503287503534 1694 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2491 paeonol 100 µM 0.3795135594294 0.361398493178558 no 1217 0.352153268561175 1635 11092 Increases levels of cortical cytochrome oxidase. SGTC_1671 st016596 74.5 µM 0.378113747739799 0.361905007498194 no 1218 0.352673047967999 1644 2829167 SGTC_1060 3448-7350 82 µM 0.375812579002726 0.362738198557054 no 1219 0.353528117751423 1769 570178 SGTC_79 0052-0007 94.094 µM 0.374181528277173 0.36332915207186 no 1220 0.35413463288443 1758 2801472 SGTC_1182 1222-0449 220 µM 0.373448014937885 0.363595020849071 no 1221 0.354407514617466 1674 658318 SGTC_3042 9091578 49.47 µM 0.373282253150312 0.363655111867352 no 1222 0.354469191701182 1683 25236497 SGTC_2103 5378138 10 µM 0.370913885990293 0.364514044506794 no 1223 0.355350836112918 1718 244142 SGTC_493 zm226600 134 µM 0.370753695799569 0.364572165100077 no 1224 0.355410496270294 1694 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1156 4092-0367 4.88 µM 0.36820673583559 0.365496676732936 no 1225 0.356359544078147 1696 1357585 SGTC_2347 9049783 174.81 µM 0.367917320653136 0.36560178006292 no 1226 0.356467442355844 1736 6467988 YPL169C MEX67 SGTC_2258 7960471 200 µM 0.36674737379184 0.366026757960441 no 1227 0.356903732940477 1655 2974708 SGTC_3122 9126309 49.47 µM 0.366692679995621 0.36604662926097 no 1228 0.356924133655818 1717 17591206 SGTC_2909 7941780 10.49 µM 0.363887668534176 0.367066224122321 no 1229 0.35797094669941 1821 1243215 SGTC_2506 ethyl hematommate 54.16 µM 0.360743004611937 0.36821039485276 no 1230 0.359145786655525 1607 3940691 An allergen. SGTC_3172 9105863 49.47 µM 0.360733430030049 0.368213880309487 no 1231 0.359149365740962 1722 2348785 SGTC_102 gallobenzophenone 83.616 µM 0.357838253003837 0.36926831447594 no 1232 0.360232180882962 1783 70837 SGTC_1896 st058441 89 µM 0.357728503481421 0.369308305070507 no 1233 0.360273250051956 1642 688759 SGTC_3001 9076041 71.4286 µM 0.356912225725587 0.369605785182853 no 1234 0.360578758430892 1669 16004211 SGTC_2442 5158906 48.48 µM 0.356125195290208 0.369892680478448 no 1235 0.360873404705902 1783 1893835 SGTC_397 arbidol 50 µM 0.355118113777313 0.37025989635715 no 1236 0.361250553536251 1777 131410 A RNA synthesis inhibitor. SGTC_2315 7733312 200 µM 0.353703093960748 0.370776060087325 no 1237 0.361780701831836 1658 726316 SGTC_2213 7173844 200 µM 0.353639974968544 0.370799089739187 no 1238 0.361804356048643 1679 892728 SGTC_2051 5263410 176 µM 0.353427179160061 0.370876734018127 no 1239 0.361884106430544 1743 227584 SGTC_3062 9077494 49.47 µM 0.352475045017514 0.371224210144815 no 1240 0.362241015171264 1756 16459633 SGTC_2594 a-mangostin 100 µM 0.352074545975621 0.371370401459205 no 1241 0.3623911785765 1824 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1692 fluoroquinolonic acid 71 µM 0.350297870493938 0.372019152174834 no 1242 0.36305758162478 1733 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_692 k241-0027 77.8 µM 0.34937429528369 0.372356538159971 no 1243 0.363404164174825 1789 3600480 SGTC_1670 st016595 4.04 µM 0.349256693428446 0.372399505660474 no 1244 0.363448303698971 1731 597879 SGTC_1485 3909-9022 254 µM 0.347243595503877 0.373135265344793 no 1245 0.364204160776484 1718 714516 SGTC_2807 7945238 51.95 µM 0.347036737337808 0.373210895438904 no 1246 0.364281859722151 1730 17148797 SGTC_1139 k015-0024 46.9 µM 0.345485975782353 0.373778029877417 no 1247 0.364864525842794 1812 2766652 SGTC_141 0443-0274 32.331 µM 0.344459897688718 0.374153430870173 no 1248 0.36525022489277 1842 1627241 SGTC_1266 0828-0227 32.9 µM 0.343801480221115 0.374394382421735 no 1249 0.365497793480244 1777 3913820 SGTC_256 clotrimazole 625 nM 0.343563775373716 0.37448138389807 no 1250 0.365587185584365 1706 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_582 0987-0078 156 µM 0.343313688681756 0.374572924106757 no 1251 0.365681241928534 1731 1625765 SGTC_1351 1496-0003 46.5 µM 0.342778557662537 0.374768823945516 no 1252 0.365882529129273 1784 3891978 SGTC_3192 9110362 49.47 µM 0.342513071920605 0.374866024505244 no 1253 0.365982404141204 1744 16649480 SGTC_904 1141-0088 396 µM 0.340220907353345 0.375705569739937 no 1254 0.36684508726047 1649 1378119 SGTC_2878 9043973 25.97 µM 0.339764673972702 0.375872743558426 no 1255 0.367016876502513 1805 6465167 SGTC_812 4251-0442 148 µM 0.338278831738927 0.376417349779605 no 1256 0.367576537121325 1828 5723007 SGTC_2183 6420625 130.508 µM 0.338253442185732 0.376426657962213 no 1257 0.367586102854721 1678 2897619 SGTC_468 gf-109203x 121 µM 0.336733270468428 0.376984105990057 no 1258 0.368158990191851 1824 2396 A protein kinase C inhibitor. SGTC_1806 st050005 60.3 µM 0.335359763980295 0.377487992407688 no 1259 0.368676857990911 1693 5194765 SGTC_560 2332-1943 155 µM 0.33487996543976 0.377664061146311 no 1260 0.368857817826714 1721 21177716 SGTC_1769 st044406 64.4 µM 0.334237768736831 0.377899763927367 no 1261 0.369100072921432 1726 670903 SGTC_2846 9008642 19.48 µM 0.334048853923808 0.37796910920222 no 1262 0.36917134693379 1696 2992898 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.332737006387156 0.37845075960646 no 1263 0.369666406324227 1959 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1512 0259-0544 12.2 µM 0.332456381802038 0.378553816668811 no 1264 0.369772335314177 1782 18476 SGTC_2738 aclarubicin 5.55 µM 0.331962729284651 0.378735127439047 no 1265 0.369958701173427 1790 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_3019 9081971 49.47 µM 0.331924893775172 0.378749024925692 no 1266 0.369972986261279 1842 16451803 SGTC_2751 anetholtrithion 17.25 µM 0.331221858982918 0.379007287474999 no 1267 0.370238455076823 1844 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_3022 9087993 49.47 µM 0.331188814634936 0.379019427774163 no 1268 0.370250934280047 1772 17173644 SGTC_289 k017-0060 526 µM 0.330487123292821 0.379277253203536 no 1269 0.370515960348167 1726 5512909 SGTC_1 0258-0098 57.368 µM 0.329324204619727 0.379704667558046 no 1270 0.370955325463211 1729 6790032 YDR047W HEM12 SGTC_2026 5148700 152 µM 0.329321605578136 0.379705622963965 no 1271 0.370956307602083 1716 79838 SGTC_2801 7907800 81.82 µM 0.328141984748032 0.380139326498151 no 1272 0.371402155319928 1705 6620925 SGTC_1385 3091-4834 14.1 µM 0.327229773772133 0.380474816587688 no 1273 0.371747051593205 1806 4072814 SGTC_2004 4023728 41.89 µM 0.325558095565093 0.381089854369336 no 1274 0.372379360579909 1863 360084 YDR527W RBA50 SGTC_458 nppb 133 µM 0.325500779910149 0.381110947074183 no 1275 0.372401046225667 1904 4549 A chloride channel blocker. SGTC_1969 st069479 40.1 µM 0.324104863193528 0.381624766592329 no 1276 0.372929322598779 1825 3895485 SGTC_2414 st077232 92.9 µM 0.323806727590153 0.381734533658455 no 1277 0.373042181255769 1640 729801 SGTC_1413 3910-0535 34.4 µM 0.323634409295117 0.381797981856678 no 1278 0.373107416982944 1808 2876951 SGTC_3346 9158254 43.5805 µM 0.323142087376125 0.38197927399853 no 1279 0.37329381873238 1730 17639500 SGTC_2665 lovastatin 100 µM 0.322125913201931 0.382353550789023 no 1280 0.373678653906679 1758 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1483 3453-0561 55.9 µM 0.322039549528935 0.382385365289844 no 1281 0.373711366494732 1799 4546991 SGTC_2081 5214970 32.255 µM 0.321623488403603 0.38253864429118 no 1282 0.373868973697999 1845 2063512 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.320309763658678 0.383022747755127 no 1283 0.374366761214924 1742 3256 An antibiotic and ribosome inhibitor. SGTC_412 gemfibrozil 100 µM 0.320287639741751 0.383030901916327 no 1284 0.374375146052924 1802 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1847 st056231 15 µM 0.319728298100959 0.383237074390615 no 1285 0.374587153066215 1708 5393180 SGTC_3152 9099253 49.47 µM 0.31955832691834 0.38329973206409 no 1286 0.37465158468263 1816 25236131 SGTC_2255 7941087 197.44 µM 0.318540264778934 0.383675091325233 no 1287 0.375037578532878 1868 935561 SGTC_1618 st003135 44.5 µM 0.31840864758037 0.38372362653162 no 1288 0.375087489770241 1848 1270615 SGTC_1400 3771-8998 51.5 µM 0.318311105080317 0.38375959751669 no 1289 0.375124480714836 1805 670767 SGTC_2243 6634756 200 µM 0.315755796178957 0.384702280952791 no 1290 0.376093936156709 1868 885676 SGTC_1423 4048-0112 5.59 µM 0.315725941603514 0.384713298697765 no 1291 0.376105267282433 1857 X1423 SGTC_2873 9040596 71.43 µM 0.314494209394586 0.385167946984991 no 1292 0.376572856882191 1703 6463863 SGTC_3226 9131256 49.47 µM 0.313335479134775 0.385595793460257 no 1293 0.377012898906705 1762 17178073 SGTC_1037 k284-1091 78.7 µM 0.310712290480122 0.386564886333873 no 1294 0.378009676487067 1718 3334711 SGTC_2656 pseudo-anisatin 100 µM 0.310596406569412 0.386607714063438 no 1295 0.37805372965755 1782 6708809 A neurotoxin. SGTC_987 1497-1013 404 µM 0.309436652301375 0.387036405575064 no 1296 0.37849469651332 1793 1676435 SGTC_2091 4-phenylthiadiazole 200 µM 0.307951747886098 0.387585486727309 no 1297 0.379059524372914 1762 270010 SGTC_693 4161-2696 114 µM 0.307509240315082 0.387749158698644 no 1298 0.37922789539428 1849 805759 SGTC_1703 st026983 48.3 µM 0.307484091562237 0.387758461163553 no 1299 0.379237465006399 1867 1104023 SGTC_1180 1193-0155 285 µM 0.307458415013178 0.387767958925515 no 1300 0.379247235532061 1744 2921347 SGTC_2273 7815444 169.05 µM 0.306035392900173 0.388294439998618 no 1301 0.379788849058633 1907 2824616 SGTC_2231 micatex 6.853 µM 0.305390068512606 0.38853326092233 no 1302 0.380034542462048 1804 20737 An antifungal of unknown mechanism. SGTC_1237 0330-0133 46.1 µM 0.304711247919183 0.388784523563829 no 1303 0.380293041085353 1762 X1237 YHR072W ERG7 SGTC_2190 6049624 200 µM 0.300784893285847 0.390238757375713 no 1304 0.381789264346875 1839 2265554 SGTC_2575 plumbagin 510 nM 0.29969554417939 0.390642501170664 no 1305 0.382204698852559 1700 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_670 4204-0025 119 µM 0.298873106825968 0.390947398025866 no 1306 0.382518433702135 1853 719039 SGTC_178 4092-0806 87.505 µM 0.298769291260264 0.390985889665353 no 1307 0.382558041670921 1785 2169044 SGTC_1357 1503-1303 39.5 µM 0.29871920879286 0.391004459095799 no 1308 0.38257714969581 1776 292895 SGTC_2415 st077333 57.7 µM 0.298164629958502 0.391210100812588 no 1309 0.382788757934441 1994 2766255 SGTC_2245 6637752 200 µM 0.295812951734427 0.392082456877341 no 1310 0.383686465689837 1912 681890 SGTC_219 mitoxanthrone 164.414 µM 0.295725437319337 0.392114930888852 no 1311 0.383719884712611 1866 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1275 0867-0008 21.1 µM 0.294444600060127 0.392590297589457 no 1312 0.384209095312852 1810 3422836 SGTC_1723 st034307 2.5525 µM 0.294095781488794 0.392719785030879 no 1313 0.384342357154059 1755 867466 SGTC_3260 9137109 49.47 µM 0.293765845629462 0.392842273813657 no 1314 0.384468417669254 1899 17478346 SGTC_964 1287-0107 19.4 µM 0.293719104425061 0.392859627357729 no 1315 0.384486277341836 1898 51516812 YPR165W RHO1 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.29369889254887 0.392867131459764 no 1316 0.384494000314428 1794 4620898 SGTC_2330 7979373 200 µM 0.293695346233689 0.392868448111108 no 1317 0.384495355368765 1664 1863007 SGTC_2418 pentamidine 31.67 µM 0.292464331211009 0.393325564808018 no 1318 0.384965813911952 1809 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1900 st060200 72.8 µM 0.292312140978827 0.393382088317104 no 1319 0.385023988422253 1760 688945 SGTC_400 oxethazaine 37.5 µM 0.289521050912679 0.394419097568803 no 1320 0.386091336522364 1788 4621 A local anesthetic. SGTC_3336 9143619 71.43 µM 0.287855832434412 0.395038154514499 no 1321 0.386728548557055 1910 45595730 SGTC_2841 9004761 38.96 µM 0.287696765528571 0.395097302673491 no 1322 0.386789433065891 1655 2991039 SGTC_1764 st044502 93.5 µM 0.287592007292256 0.395136257771056 no 1323 0.386829531889758 1798 8407 SGTC_659 k018-0002 107 µM 0.286513636641372 0.395537318449271 no 1324 0.38724237526544 1938 6797879 YHR007C ERG11 SGTC_2922 7999257 32.47 µM 0.282802940745111 0.396918219595675 no 1325 0.388663949965722 1791 2988377 SGTC_977 1348-1378 135 µM 0.281774369487575 0.397301222585395 no 1326 0.389058262556949 1817 X977 SGTC_1716 st033144 30.6155 µM 0.2781140005331 0.398665013522462 no 1327 0.3904624243392 1934 674617 SGTC_1501 4491-0275 38.4 µM 0.278108733219155 0.398666976929872 no 1328 0.390464445979164 1930 5104718 SGTC_2826 7992541 19.48 µM 0.275894679385608 0.399492498795455 no 1329 0.391314480306359 1870 2985066 SGTC_2100 5377183 190 µM 0.274423165594708 0.400041409544265 no 1330 0.391879721259923 1902 2844202 SGTC_396 dithiazanine 1.25 µM 0.273818637607044 0.400266970628743 no 1331 0.39211200003946 1780 10578 An antihelmenthic. SGTC_1238 0333-0287 48.8 µM 0.272361346657109 0.400810850704067 no 1332 0.39267209525127 1808 7226 SGTC_1395 3486-0190 4.35 µM 0.272288396602472 0.400838081683658 no 1333 0.39270013872874 1955 6748079 SGTC_681 1642-0006 26.6 µM 0.26969891023975 0.40180500282989 no 1334 0.393695949496473 1860 4446530 SGTC_3092 9117248 49.47 µM 0.269490108151273 0.40188299636959 no 1335 0.393776276650711 1916 17141857 SGTC_1473 k844-0725 134 µM 0.266962670536169 0.402827375507534 no 1336 0.394748951438725 1871 54682906 SGTC_537 1334-0398 209 µM 0.266510404482379 0.402996425078095 no 1337 0.394923073732461 1974 5846986 SGTC_109 0132-0036 33.701 µM 0.266057623348679 0.403165685341789 no 1338 0.395097415356516 1947 67274 A color developer. SGTC_2994 9053520 71.4286 µM 0.265142591663489 0.403507801116042 no 1339 0.395449808846005 1938 4647384 SGTC_1122 capsaicin 818.572 nM 0.261784828380488 0.404763846164299 no 1340 0.396743668238579 1906 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.261591007412726 0.40483637925022 no 1341 0.396818388856861 1810 75037 A free radical scavenger. SGTC_751 0833-0568 350 µM 0.258837008593171 0.405867352798499 no 1342 0.397880500963301 1866 6954252 SGTC_1039 k821-0043 94 µM 0.258156642649609 0.406122152167643 no 1343 0.39814300906629 1949 15992768 SGTC_2252 omeprazole 400 µM 0.257404198204093 0.406403991487743 no 1344 0.398433381176622 1926 4594 A proton pump inhibitor. SGTC_126 0417-1624 672.48 µM 0.256979826845116 0.406562967525888 no 1345 0.398597173042723 1996 41912 YDL195W SEC31 SGTC_2900 5328528 85.29 µM 0.256363506720157 0.406793877944087 no 1346 0.398835081934248 1812 795359 SGTC_213 1246-0773 967 nM 0.256032643914202 0.406917852333913 no 1347 0.398962815495476 1902 6251622 SGTC_632 0781-2353 4.65 µM 0.2556754982519 0.407051685386098 no 1348 0.399100708013281 1900 6811515 YHR007C ERG11 SGTC_1294 1000-1494 117 µM 0.254330402957151 0.407555829703041 no 1349 0.399620156831547 1811 712797 YDL207W GLE1 SGTC_1061 3448-9325 110 µM 0.25335166155148 0.407922760182137 no 1350 0.399998238891154 1981 723482 SGTC_2473 5854593 8.94 µM 0.252046938231304 0.408412026948215 no 1351 0.400502391599234 1843 2872951 SGTC_1530 rhein 70.4 µM 0.251832183113876 0.408492573087263 no 1352 0.400585390144785 1927 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2387 9077560 195.08 µM 0.249914235974565 0.409212090144162 no 1353 0.401326836886758 1833 5303272 SGTC_2701 st077767 14.721 µM 0.248129141159995 0.409882042695864 no 1354 0.40201724455853 1845 5721188 SGTC_368 fentichlor 4.58 µM 0.2470846908643 0.410274150842132 no 1355 0.402421340700519 1829 7329 A pesticide. SGTC_725 1497-0963 19 µM 0.246917213230488 0.410337033750926 no 1356 0.402486147241764 2003 3549977 SGTC_185 k048-0037 25.491 µM 0.245624951153313 0.410822317426633 no 1357 0.402986286306066 1993 6827589 SGTC_3131 9127911 49.47 µM 0.245235750143996 0.41096850101787 no 1358 0.403136948375181 1898 45595681 SGTC_3334 9142812 21.919 µM 0.244952229255037 0.4110749990255 no 1359 0.403246710084226 1939 45283678 SGTC_546 peri-Naphthalide 147 µM 0.243995485738754 0.411434425740155 no 1360 0.40361715806974 1935 223824 A penicillin ester. SGTC_1092 toremifene 6.32 µM 0.243647014391746 0.411565356962108 no 1361 0.403752106548908 1964 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2025 5147754 141 µM 0.240931301076293 0.41258606892747 no 1362 0.404804180923113 1986 315777 YLR208W SEC13 SGTC_1054 3429-0080 167 µM 0.238617524525504 0.413456178215451 no 1363 0.405701087504549 1954 1162877 SGTC_1117 retinoic acid 1.10837 µM 0.238170918055288 0.413624176293601 no 1364 0.405874266096183 2003 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_3191 9110352 49.47 µM 0.235977369218178 0.414449543333423 no 1365 0.406725115532747 1897 17122424 SGTC_1882 5615643 20 µM 0.235711200296781 0.414549720546055 no 1366 0.406828389088711 1986 2253075 SGTC_935 2996-0153 430 µM 0.235303671804992 0.414703111611434 no 1367 0.40698652271835 2035 23738523 SGTC_2921 7974240 10.71 µM 0.234864825699835 0.41486830496637 no 1368 0.407156825505064 1929 2979074 YDR527W RBA50 SGTC_652 0437-0092 114 µM 0.23372796441409 0.415296319761708 no 1369 0.407598088254446 1855 3091274 SGTC_1205 4161-2785 76 µM 0.232088988117524 0.415913551733977 no 1370 0.408234448800032 1789 3498106 SGTC_1157 4092-0394 27.6 µM 0.231917630802934 0.415978096225095 no 1371 0.408300995212312 1973 3659885 SGTC_900 1112-0045 141 µM 0.230895347730964 0.416363202634653 no 1372 0.408698052532973 1998 56211 YIL048W NEO1 SGTC_2239 6685329 187.64 µM 0.230287705143051 0.416592147029079 no 1373 0.408934106885656 1854 805680 SGTC_1097 itavastatin 7.23 µM 0.230007608710639 0.416697689829659 no 1374 0.409042928659 1911 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1200 1643-0193 18.4 µM 0.229753699180459 0.41679337036443 no 1375 0.409141582476575 2004 5403974 SGTC_2744 captopril 92.04 µM 0.229314869212314 0.416958745945139 no 1376 0.409312098707313 2011 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_399 oxolinic acid 75 µM 0.227151917385281 0.417774080874397 no 1377 0.410152807381117 1896 4628 A DNA gyrase inhibitor. SGTC_1288 0973-0013 65.5 µM 0.227076743863195 0.417802424267396 no 1378 0.410182033712892 1932 4315430 SGTC_2778 tioconazole 65.09 nM 0.226643995092546 0.417965595980487 no 1379 0.410350289606879 1909 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.224790571319076 0.418664605074714 no 1380 0.411071100689057 2043 5024745 SGTC_835 0312-0010 67.2 µM 0.224578875966599 0.418744461259087 no 1381 0.411153449834304 1890 1626196 SGTC_666 0272-0154 136 µM 0.224518261370177 0.418767327046641 no 1382 0.411177029534152 1924 6870312 SGTC_1984 st072354 53.1 µM 0.223667984773503 0.41908810779009 no 1383 0.41150782963853 1933 5762938 SGTC_2284 7945075 39.21 µM 0.220126670459987 0.42042470275168 no 1384 0.412886252085954 2033 1245402 SGTC_1014 4130-3005 69.3 µM 0.218490862070934 0.421042415313635 no 1385 0.413523338676898 1868 743608 SGTC_1213 1315-0166 115 µM 0.217837006628852 0.421289378119085 no 1386 0.413778054878159 1794 768401 SGTC_3176 9106582 49.47 µM 0.217835216910133 0.421290054142783 no 1387 0.413778752131577 2032 17018027 SGTC_2493 resveratrol 26.09 µM 0.217602340499733 0.421378019649096 no 1388 0.413869480367216 1904 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_361 000s-0510 1.45 µM 0.21683842523354 0.421666604497594 no 1389 0.414167132650662 1906 660 SGTC_2099 5377090 177.372 µM 0.215205984911291 0.422283433550763 no 1390 0.414803362482472 1898 2243829 SGTC_1649 st011737 51.3 µM 0.214461049359845 0.422564976131659 no 1391 0.415093769204804 1910 1761035 SGTC_743 1275-0778 158 µM 0.214013015601038 0.422734326058643 no 1392 0.415268453669894 2027 2849257 YMR203W TOM40 SGTC_2777 climbazole 1.536 µM 0.213699253811194 0.422852931733817 no 1393 0.41539079663702 1998 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_752 1896-0090 130 µM 0.212288504686597 0.423386297884761 no 1394 0.415940981495267 1917 772567 SGTC_1746 st038117 42 µM 0.212017554621354 0.423488752893104 no 1395 0.416046669515887 1890 2898218 SGTC_1842 st055362 61.2 µM 0.209435012925511 0.424465554360299 no 1396 0.417054331202868 1969 676032 SGTC_25 0118-0223 35.662 µM 0.209388870476202 0.424483011176865 no 1397 0.417072340139634 2018 5333628 SGTC_573 3702-0553 84.7 µM 0.208121601105985 0.424962507945548 no 1398 0.41756701059347 1928 1222756 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.208046049121048 0.424991098067753 no 1399 0.417596505954241 1915 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3266 9136860 49.47 µM 0.204399871121454 0.426371338420563 no 1400 0.419020515444321 1938 4871271 YPR165W RHO1 SGTC_543 3844-1095 191 µM 0.204339618822977 0.426394154216767 no 1401 0.419044055858372 2004 4230703 SGTC_202 3594-0513 34.79 µM 0.204106444270158 0.426482452971108 no 1402 0.419135159271395 2043 708429 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.202978917261685 0.426909477850621 no 1403 0.41957575539219 2023 5282309 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.202937302469189 0.426925240137013 no 1404 0.419592018856888 1904 4330530 SGTC_1242 0402-0103 60.1 µM 0.202417334665215 0.427122196315164 no 1405 0.419795238890709 1957 432868 SGTC_325 2810-4341 181 µM 0.202300156966162 0.427166584019253 no 1406 0.419841038635239 2056 774970 SGTC_2688 kanamycin b 96.69 µM 0.202242746101362 0.427188331979338 no 1407 0.419863478480036 1953 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1998 st075797 76.8 µM 0.202158777149282 0.427220140876545 no 1408 0.41989629939636 2057 24208315 SGTC_2300 7976697 71.57 µM 0.202132590952054 0.427230060759592 no 1409 0.419906534900522 1900 2236109 SGTC_711 k292-0785 179 µM 0.20199667317104 0.427281550016851 no 1410 0.41995966250013 1975 4146315 SGTC_1739 st037196 92.5 µM 0.201119315381882 0.427613946166381 no 1411 0.420302639538729 2077 612214 SGTC_2298 7976326 193.81 µM 0.200769566436922 0.427746466540299 no 1412 0.420439380415541 2019 2235818 SGTC_705 1124-0212 310 µM 0.200490326431832 0.427852276829095 no 1413 0.42054856140089 2060 9554485 SGTC_205 1486-1330 71.903 µM 0.200238395504871 0.427947743549318 no 1414 0.420647069963678 1960 4118834 SGTC_1159 4092-0538 61.2 µM 0.199895922491513 0.428077527056098 no 1415 0.42078098973371 1946 717301 SGTC_1615 st002656 86.5 µM 0.198939277163796 0.428440098363191 no 1416 0.421155122399146 2043 1584458 SGTC_1790 st045711 43.5 µM 0.198237420863747 0.428706142338775 no 1417 0.421429655396643 2076 585119 SGTC_129 0088-0017 176.636 µM 0.198204964333455 0.42871844601844 no 1418 0.421442351781687 2064 182446 SGTC_2069 5228469 200 µM 0.197966012554784 0.428809030418522 no 1419 0.421535827742799 1947 2835210 SGTC_2866 9034245 58.44 µM 0.19767458117634 0.428919514422996 no 1420 0.421649839274451 2094 6462273 SGTC_294 k038-0071 157 µM 0.19747842671344 0.428993881310892 no 1421 0.421726581006328 1941 24152826 SGTC_3016 9080866 49.47 µM 0.19677849170906 0.429259264079218 no 1422 0.422000441577437 1975 17066299 SGTC_3020 9089140 49.47 µM 0.196032383609722 0.429542188743883 no 1423 0.422292409631243 1937 17217859 SGTC_2057 5236571 38.335 µM 0.19581573299072 0.429624349583025 no 1424 0.422377197659103 2047 54684039 YBR257W POP4 SGTC_2384 9036245 200 µM 0.195698248224701 0.42966890483616 no 1425 0.422423177807228 2033 6462766 SGTC_18 0111-0177 500 nM 0.195446737536333 0.429764291468038 no 1426 0.42252161538818 1972 721752 SGTC_204 PMA1.184 62.41 µM 0.194263591627307 0.430213060133875 no 1427 0.422984746103905 2015 2252213 YGL008C PMA1 SGTC_2582 agaric acid 100 µM 0.193088491930091 0.430658866109475 no 1428 0.423444832586987 1937 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2000 st075254 36.4 µM 0.192310765595643 0.430953966351383 no 1429 0.423749393032888 1950 17234175 SGTC_2750 bromebric acid 70.15 µM 0.187051569312345 0.432950517896943 no 1430 0.425810099976365 1977 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1191 1487-1166 10.6 µM 0.184683693581759 0.433849998099007 no 1431 0.426738568396978 2048 3955771 SGTC_2390 9097792 176.6 µM 0.183523828731544 0.434290718954863 no 1432 0.42719351182813 1903 4497149 SGTC_371 0195-0006 7.36 µM 0.183434165262065 0.43432479233343 no 1433 0.42722868531656 1956 3928593 SGTC_311 1315-0136 58 µM 0.183222023836107 0.43440541099914 no 1434 0.427311907174229 2064 6759207 SGTC_3326 9140064 16.379 µM 0.182732647068183 0.434591395928731 no 1435 0.427503899189467 1949 1868434 SGTC_2322 7413319 38.22 µM 0.181397779253902 0.435098778525038 no 1436 0.428027680931389 1982 1840400 SGTC_2783 7738165 71.43 µM 0.181205460329029 0.435171887681687 no 1437 0.428103154415268 1892 17201110 SGTC_694 1315-0438 43.2 µM 0.181152519739243 0.43519201319303 no 1438 0.428123930839445 2019 6793154 SGTC_2843 9000894 45.46 µM 0.180280181443224 0.435523659140905 no 1439 0.428466306836333 2044 2242070 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.180184405367301 0.435560074097823 no 1440 0.428503900388509 2096 688662 SGTC_2198 6589944 200 µM 0.179772852801535 0.43571655643469 no 1441 0.428665448347827 2040 5290268 SGTC_2266 7929956 200 µM 0.177357339810685 0.436635195580261 no 1442 0.429613856971226 2102 2967153 SGTC_2818 7996756 12.99 µM 0.176091672110981 0.437116676051574 no 1443 0.430110961694341 2005 2241621 SGTC_2586 curcumin 80 µM 0.175842385749631 0.437211519619837 no 1444 0.430208884703385 2059 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_192 3455-0609 60.9 µM 0.175421519934652 0.43737165054739 no 1445 0.430374216149245 2020 3769639 SGTC_634 1611-4317 11.2 µM 0.174299845647194 0.437798474957833 no 1446 0.430814910271443 2132 2843522 SGTC_826 1683-5028 118 µM 0.17404752353618 0.437894499662497 no 1447 0.430914056886783 1994 722377 SGTC_349 k015-0014 24 µM 0.173164022146074 0.438230757246908 no 1448 0.431261251274496 1941 2196908 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.172810004802365 0.43836550755774 no 1449 0.431400386334179 2017 5106787 A p450 inhibitor. SGTC_1646 st011709 75.6 µM 0.172574051255062 0.438455322985329 no 1450 0.431493124968082 2107 5757843 SGTC_2332 7982454 138.89 µM 0.172469585298342 0.438495088835909 no 1451 0.431534185231327 2088 2981748 SGTC_2194 5927483 104.545 µM 0.172087729203023 0.438640450870659 no 1452 0.431684279764513 2075 760979 SGTC_1767 st044992 70.3 µM 0.172018525945518 0.438666795519795 no 1453 0.431711482247694 1984 9600693 SGTC_2710 st078562 53.7235 µM 0.170759604495977 0.439146095481887 no 1454 0.432206396706829 2077 17250908 SGTC_2116 5511452 16.8835 µM 0.168952471715138 0.439834267750558 no 1455 0.43291701296802 2043 870744 SGTC_118 0083-0097 135.343 µM 0.164248693398765 0.441626355930344 no 1456 0.434767684893845 1996 5207356 SGTC_3068 9116768 49.47 µM 0.164097609751733 0.441683937164421 no 1457 0.434827151724631 2019 41904888 SGTC_94 0334-0113 514.748 µM 0.16408678208135 0.441688063870306 no 1458 0.43483141357435 1977 6795178 SGTC_3184 9108758 49.47 µM 0.162834063365556 0.442165550063632 no 1459 0.435324543751085 2062 902885 SGTC_2895 9054447 58.44 µM 0.161166683439505 0.442801218755062 no 1460 0.435981060404464 2003 2697450 SGTC_1697 st025554 27.742 µM 0.160641877383353 0.443001325346781 no 1461 0.436187734914281 2072 1269519 SGTC_2463 5473429 200 µM 0.159895882036727 0.443285795600445 no 1462 0.436481546221679 2015 5399405 SGTC_2620 irigenin 100 µM 0.158606883512363 0.443777397958381 no 1463 0.4369893025968 2075 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1702 st027038 51 µM 0.15841126976525 0.443852009332411 no 1464 0.437066366958461 2034 5521182 SGTC_3112 9123419 49.47 µM 0.157357916312262 0.444253815593603 no 1465 0.437481389056884 2170 17015854 SGTC_2323 6148992 148.28 µM 0.156635261381556 0.444529508630047 no 1466 0.437766155491065 2006 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1001 4048-4355 44.4 µM 0.153841917445645 0.445595421232641 no 1467 0.438867190947627 2049 21824233 SGTC_485 niflumic acid 177 µM 0.152761284203744 0.446007886212325 no 1468 0.439293265020978 2099 4488 A COX2 inhibitor. SGTC_2944 9067346 25.62 µM 0.152561990178301 0.446083960789688 no 1469 0.439371850734924 2055 6473075 SGTC_825 1988-2224 89.6 µM 0.15194261721166 0.446320400687876 no 1470 0.439616097413251 2039 1180859 SGTC_459 nigericin 15.3 µM 0.150204911055041 0.446983855560392 no 1471 0.440301475696693 2062 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_162 k030-0015 37.8 µM 0.149629456785147 0.447203596357963 no 1472 0.440528483328174 2117 1809920 YMR134W ERG29 SGTC_2540 epiandrosterone 100 µM 0.147701777696263 0.447939810332923 no 1473 0.441289064313913 2193 441302 A steroid. SGTC_1223 0764-0573 147 µM 0.14761857954618 0.447971589200909 no 1474 0.441321895695554 2095 1609797 SGTC_3183 9108214 49.47 µM 0.147582410712495 0.447985404571262 no 1475 0.441336168648069 2136 4974831 SGTC_2858 9025781 8.96 µM 0.147489183161322 0.448021014889193 no 1476 0.441372958474534 2144 4894980 YPL153C RAD53 SGTC_2061 5245884 80.95 µM 0.144850914358176 0.449028932399183 no 1477 0.442414291124501 2075 573863 SGTC_2120 5538279 151.968 µM 0.144083982357374 0.449321991164959 no 1478 0.442717076481688 2065 2058197 SGTC_1222 0366-0074 1.18 µM 0.143638955944162 0.44949205659517 no 1479 0.442892788612137 2161 286520 SGTC_2854 9024559 71.43 µM 0.14181724252984 0.450188314982912 no 1480 0.443612182078976 2022 3163529 SGTC_1016 4226-1401 38 µM 0.138456236388506 0.451473291535767 no 1481 0.444939927363001 2157 2901613 SGTC_2580 diallyl disulphide 81.36 µM 0.136549641111892 0.452202446132177 no 1482 0.445693392042549 2053 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_3 0833-0587 95.581 µM 0.13627412566603 0.452307827116248 no 1483 0.445802288887179 2083 5382644 SGTC_452 diindolylmethane 8 µM 0.136063189399602 0.452388509696595 no 1484 0.445885663723939 2109 3071 Inhibits expression of several cancer promoting factors. SGTC_731 3966-0296 387 µM 0.13413407204439 0.453126482929031 no 1485 0.446648278743886 2130 660956 SGTC_3287 9117173 37.0625 µM 0.134124579919013 0.453130114491769 no 1486 0.446652031643141 2194 2789709 SGTC_381 3461-2219 42.7 µM 0.133897758277162 0.453216894643845 no 1487 0.446741711479846 2142 2883159 SGTC_1750 st081859 2.357 µM 0.13301614954414 0.453554212297918 no 1488 0.447090304252346 2085 5291695 SGTC_2745 rifampicin 24.3 µM 0.131507178868094 0.454131646336135 no 1489 0.44768705398997 2192 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2755 lomerizine 42.69 µM 0.131078601976656 0.454295666517851 no 1490 0.44785656412402 2069 3949 A calcium channel blocker. SGTC_2029 5175081 200 µM 0.130483857713433 0.454523293335103 no 1491 0.448091812315483 2167 1380876 SGTC_3083 9117465 49.47 µM 0.129714249805166 0.454817867974046 no 1492 0.448396254054557 2008 16420915 SGTC_968 1309-0633 340 µM 0.128300932859147 0.455358892878863 no 1493 0.4489554134466 2183 3761976 SGTC_3252 9135871 49.47 µM 0.126761234685275 0.455948391368502 no 1494 0.449564689202373 2153 17682838 SGTC_2882 9058044 58.44 µM 0.126704473605024 0.455970125132875 no 1495 0.449587152477127 2006 18076804 SGTC_1856 st057054 55.7 µM 0.126448322415226 0.456068206820983 no 1496 0.449688526667621 2189 1266018 SGTC_1151 3909-8316 15.3 µM 0.122602741332537 0.457541019262906 no 1497 0.451210841777151 2094 800431 SGTC_1004 4084-0029 199 µM 0.121827666230574 0.45783793521382 no 1498 0.45151775133199 2191 716894 YLR208W SEC13 SGTC_1323 1348-1351 11.2 µM 0.12062148267457 0.458300047035521 no 1499 0.451995426184601 2054 6989654 SGTC_1805 st050013 60.3 µM 0.119626012325358 0.458681473111964 no 1500 0.452389706417301 2153 4037144 SGTC_49 0717-0965 32.132 µM 0.118704518138537 0.45903458827635 no 1501 0.452754728451855 2142 5889349 YGL099W LSG1 SGTC_1500 4488-1866 171 µM 0.117694108734192 0.459421812759564 no 1502 0.453155017443173 2194 2900003 SGTC_2110 5483698 200 µM 0.117260463034832 0.459588012898396 no 1503 0.45332682737916 2088 2848765 YHR062C RPP1 SGTC_1184 1269-1718 139 µM 0.11704629607115 0.459670097673352 no 1504 0.453411683313013 2182 5403821 SGTC_2886 9058944 51.95 µM 0.116460343425083 0.459894687263339 no 1505 0.453643856772244 2205 4949929 SGTC_2566 crystal violet carbinol 226 nM 0.115775048313648 0.460157370023723 no 1506 0.453915413036557 1946 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_3057 9095946 49.47 µM 0.11514223022025 0.46039995308957 no 1507 0.454166193801318 2213 24540043 SGTC_2293 7624732 200 µM 0.114900691979271 0.460492547707567 no 1508 0.454261918304226 2176 894453 SGTC_2997 9067075 71.4286 µM 0.114445550668211 0.460667033705777 no 1509 0.454442303481866 2129 27209819 SGTC_2686 alizarin 95.37 µM 0.113271665869499 0.461117096860327 no 1510 0.45490759000155 2094 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_506 n9-isopropylolomoucine 153 µM 0.111842843951108 0.461664969128705 no 1511 0.455474008026405 2228 6610355 SGTC_3355 9151058 44.0485 µM 0.110042378940982 0.462355448947445 no 1512 0.456187882722555 2232 17015728 SGTC_919 tnp00227 403.569 nM 0.105555371594775 0.464076709205043 no 1513 0.457967567581544 2130 1269246 A methoxyflavone. YNL221C POP1 SGTC_3288 9119690 36.221 µM 0.105134995972232 0.464238004394895 no 1514 0.45813434520127 2106 17595618 YKL019W RAM2 SGTC_2147 5545932 89.7195 µM 0.104343550194326 0.464541692539729 no 1515 0.458448359227617 2119 797404 SGTC_2676 harmalol 100 µM 0.104294100123206 0.4645606678693 no 1516 0.458467979900599 2197 5459187 A monoamine oxidase inhibitor SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.104065725541195 0.464648302417358 no 1517 0.458558595096299 2241 4000243 SGTC_876 0720-0963 56.8 µM 0.102872606528709 0.465106167693161 no 1518 0.459032039575738 2233 765861 SGTC_2471 5466956 24.79 µM 0.10189366735561 0.465481874937808 no 1519 0.459420538259908 2132 724419 SGTC_2143 5623677 140.463 µM 0.100973399761725 0.465835092671859 no 1520 0.459785788074012 2214 5375313 SGTC_2830 7992007 71.43 µM 0.0998353493078807 0.46627193716513 no 1521 0.460237521772425 2150 1952075 SGTC_1516 st013856 110 µM 0.0996059727436001 0.466359989068309 no 1522 0.46032857592366 2154 5281404 A mutagen and neurotoxin. SGTC_2769 toremifene 3.73 µM 0.0984169160457909 0.466816464372206 no 1523 0.460800621412803 2193 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2610 ononetin 44.17 µM 0.0974133360151572 0.467201769731432 no 1524 0.461199077244558 2142 259632 SGTC_3149 9097855 49.47 µM 0.0958188375466609 0.467814009987362 no 1525 0.461832227999779 2233 25236625 YMR079W SEC14 SGTC_754 3474-0146 171 µM 0.0949483463475372 0.468148285087632 no 1526 0.462177927558249 2068 24762078 SGTC_395 anisomycin 6.25 µM 0.0948354383173757 0.468191644262162 no 1527 0.462222769003349 2119 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2199 6590217 200 µM 0.0945967600044799 0.468283303241278 no 1528 0.46231756171916 2198 703109 SGTC_2350 9023895 38.85 µM 0.0937636603908647 0.46860324935045 no 1529 0.46264844963703 2177 2997209 SGTC_3010 9080089 71.4286 µM 0.0936146156143855 0.46866049110412 no 1530 0.46270764951098 2232 17027233 SGTC_433 pimozide 108 µM 0.0930281404157319 0.468885737540266 no 1531 0.462940602668567 2201 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2716 st080858 38.6235 µM 0.0926208924290342 0.469042154378705 no 1532 0.463102372667758 2240 5296050 SGTC_2382 9035899 200 µM 0.091743781848698 0.469379053429239 no 1533 0.463450805583406 2216 6462679 SGTC_1996 st072960 66.8 µM 0.0913265648901621 0.469539314589633 no 1534 0.463616555228256 2263 1719405 SGTC_2912 7964298 10.93 µM 0.0910485768271914 0.469646097960379 no 1535 0.463726996295533 2153 2975850 SGTC_1506 4226-2149 212 µM 0.0902589555589898 0.469949426538209 no 1536 0.464040717846315 2139 991114 SGTC_863 0466-0191 129 µM 0.0900362379205131 0.470034985429584 no 1537 0.464129209031456 2254 765160 YPR165W RHO1 SGTC_3163 9099914 49.47 µM 0.0899344533138949 0.470074087320204 no 1538 0.464169651145378 2241 16268368 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.0887998934692378 0.470509962803821 no 1539 0.464620471178573 2191 5377381 SGTC_994 3910-0338 138 µM 0.0885234436246411 0.470616174747625 no 1540 0.464730326081257 2214 3479481 SGTC_2404 5161160 200 µM 0.0881476391288157 0.470760562068124 no 1541 0.464879666580302 2190 2831543 SGTC_1306 1185-0270 9.02 µM 0.0879703419155136 0.470828682518526 no 1542 0.464950124226641 2224 1548076 SGTC_3248 9135562 49.47 µM 0.0874338309418695 0.471034823883768 no 1543 0.465163339567064 2214 17650701 SGTC_1271 0832-2808 169 µM 0.0863607684279382 0.471447145431158 no 1544 0.465589816316506 2243 3663794 SGTC_1909 st060837 51.5 µM 0.0851219164189071 0.471923209208429 no 1545 0.466082233378816 2170 678937 SGTC_1456 k015-0012 13 µM 0.0836483579900628 0.472489517720117 no 1546 0.466668008758964 2271 2989616 SGTC_2856 9022925 19.48 µM 0.0836423866926446 0.472491812684706 no 1547 0.466670382642934 2184 4944862 SGTC_12 0849-0099 9.267 µM 0.083291847680436 0.472626537871669 no 1548 0.466809741189906 2277 6071388 SGTC_531 3788-1495 174 µM 0.0828271814932044 0.472805131203542 no 1549 0.466994477838029 2170 2896655 SGTC_3063 1327-0034 4 µM 0.0827896467094257 0.472819557846569 no 1550 0.467009400797342 2244 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1344 1488-0097 29.1 µM 0.0812851217837851 0.473397857124409 no 1551 0.467607602965244 2201 747966 SGTC_121 0557-0495 61.343 µM 0.080984602666079 0.473513375420046 no 1552 0.467727098786445 2245 3104427 SGTC_1076 itraconazole 331 nM 0.0809280490883649 0.473535114628798 no 1553 0.467749586587127 2266 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_3279 9140807 49.47 µM 0.0803124977551226 0.473771737791842 no 1554 0.467994359276132 2238 45595718 SGTC_3097 9117246 49.47 µM 0.0802765890684382 0.473785541682607 no 1555 0.468008638664078 2263 16423892 SGTC_364 0083-0097 67.7 µM 0.0798243175694126 0.47395940498744 no 1556 0.468188491705676 2174 5207356 SGTC_847 0342-0274 5.54 µM 0.0796944427093696 0.474009332713772 no 1557 0.468240139735935 2247 18097 SGTC_2603 homopterocarpin 100 µM 0.078990404079946 0.474279993010431 no 1558 0.468520127824714 2191 101795 A weak amylase inhibitor. SGTC_2145 5634607 200 µM 0.0787924110805993 0.474356111494975 no 1559 0.468598870181107 2209 308662 SGTC_729 4092-0585 94.1 µM 0.0778280061017758 0.474726890693296 no 1560 0.468982434181856 2198 2169061 SGTC_1042 0350-0096 82 µM 0.0755552190473745 0.47560078198354 no 1561 0.469886482298863 2159 3122515 SGTC_887 0885-0007 9.62 µM 0.0744790519971994 0.476014611631424 no 1562 0.470314604475065 2253 5719458 SGTC_2023 5144124 124 µM 0.073592016536667 0.476355732024219 no 1563 0.470667511897655 2236 2830192 SGTC_2446 5162541 200 µM 0.0722139768049589 0.47688570842642 no 1564 0.471215811166365 2261 1549321 SGTC_1610 st001799 48.1 µM 0.0714528717752772 0.477178437243754 no 1565 0.471518665755371 2179 621897 SGTC_2507 purpurin 79.67 µM 0.0709946769371322 0.477354669636416 no 1566 0.471700995995586 2267 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_3181 9108277 49.47 µM 0.0701093829207011 0.477695186822247 no 1567 0.472053299295343 2255 17097298 SGTC_1878 temozolomide 1 mM 0.0697258349410275 0.477842718789207 no 1568 0.472205939255645 2290 5394 DNA alkylating agent. SGTC_3133 9127736 49.47 µM 0.0695572597105991 0.477907562317341 no 1569 0.472273028156252 2294 27243420 SGTC_1965 Pectolinarigenin 58.4 µM 0.069517119120417 0.477923002735404 no 1570 0.472289003264922 2252 5320438 An anti-inflammatory. SGTC_2583 asiatic acid 100 µM 0.0691457338196467 0.478065860806136 no 1571 0.472436808896129 2250 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_3159 9100096 49.47 µM 0.0690273262420953 0.478111408377443 no 1572 0.472483934087745 2275 25236875 SGTC_1591 genipin 88.4 µM 0.0688785312599846 0.478168645407264 no 1573 0.472543153749568 2266 442424 A DNA cross-linking agent. SGTC_324 1315-0088 19.6 µM 0.0687200070163276 0.478229625491693 no 1574 0.472606246276758 2277 6787421 SGTC_1573 oleylamine 1.06 µM 0.0685199465455956 0.478306584191571 no 1575 0.472685871171267 2243 5356789 An amine of the fatty acid oleic acid. SGTC_723 4182-0001 115 µM 0.0677771841241065 0.478592315007067 no 1576 0.472981503209898 2186 744821 YLR208W SEC13 SGTC_3143 9086658 49.47 µM 0.0666050632243251 0.479043236637906 no 1577 0.473448057414562 2158 25236626 SGTC_2981 9013952 38.96 µM 0.0662384688911627 0.479184273113763 no 1578 0.473593985132016 2098 2996344 SGTC_3041 9091929 49.47 µM 0.0659767833952272 0.479284950570067 no 1579 0.473698154669539 2250 25236887 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.065074516997816 0.479632086841415 no 1580 0.474057334953033 2253 2724278 An inhibitor of dopamine biosynthesis. SGTC_2108 5365811 200 µM 0.0646270089138691 0.479804266005098 no 1581 0.474235489826918 2248 780283 SGTC_2462 5162487 171.77 µM 0.0642829659140634 0.479936639442492 no 1582 0.474372458315384 2293 2259986 SGTC_1945 st075991 56.6 µM 0.0634583853906312 0.480253912712494 no 1583 0.474700748034191 2135 1084980 SGTC_1768 st044301 37.178 µM 0.0624292585549001 0.480649906650085 no 1584 0.475110497719605 2297 3931349 SGTC_2513 baicalein 25.65 µM 0.0619895315083869 0.480819113451822 no 1585 0.475285584307572 2237 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_831 k061-1017 217 µM 0.0619095684144341 0.480849883592488 no 1586 0.475317423811981 2263 1240153 SGTC_342 k048-0088 23.3 µM 0.0614573078446505 0.48102391753694 no 1587 0.475497506753429 2291 6820570 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.0606118241454675 0.481349276961567 no 1588 0.475834178266611 2183 2374 Ca(2+)-ATPase inhibitor. SGTC_3007 9078383 71.4286 µM 0.060567897149102 0.481366181309815 no 1589 0.475851670465146 2242 6496995 SGTC_635 k038-0028 24.7 µM 0.060370719187082 0.481442061368188 no 1590 0.47593018940581 2232 4035102 SGTC_3174 9107204 49.47 µM 0.0600686075960769 0.481558324371992 no 1591 0.47605049615385 2270 3938802 SGTC_1840 st055363 71 µM 0.0595882845158716 0.481743172554445 no 1592 0.476241774695122 2160 676033 SGTC_1944 st076371 56.9 µM 0.0589030056375159 0.482006902987833 no 1593 0.476514682028985 2239 24208455 SGTC_274 sirtinol 40.1 µM 0.0582596158169428 0.48225451953404 no 1594 0.476770917378963 2150 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_583 1488-1091 88.9 µM 0.0576485965917223 0.482489684194571 no 1595 0.477014269763719 2314 4303273 SGTC_1316 1272-0050 65.9 µM 0.0568026789006769 0.482815264916361 no 1596 0.477351189965799 2317 7340392 SGTC_1682 st012968 530 nM 0.0564648107894454 0.482945308375957 no 1597 0.477485763851921 2171 24207270 SGTC_1446 4239-0190 62 µM 0.0562182506906255 0.483040209061641 no 1598 0.477583971103005 2213 1340085 SGTC_1451 4152-0210 104 µM 0.055523021750381 0.483307807002127 no 1599 0.477860894766309 2311 659563 SGTC_2971 9092186 9.93 µM 0.0554837570487721 0.483322920455295 no 1600 0.477876535006477 2153 25236400 SGTC_2616 abietic acid 100 µM 0.0547799721520658 0.483593819721009 no 1601 0.478156878173708 2326 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2936 9038235 15.59 µM 0.0544966764740317 0.483702867387539 no 1602 0.478269728223123 2311 4749415 SGTC_3267 9137951 49.47 µM 0.0540257759455217 0.483884131595806 no 1603 0.478457313996128 2196 16643986 SGTC_297 0986-0032 24 µM 0.053754090932807 0.483988713095236 no 1604 0.478565543364361 2286 2847425 SGTC_1403 3909-7815 62.9 µM 0.0529980414166114 0.484279749984982 no 1605 0.478866734122647 2269 6615483 SGTC_1361 1608-0041 5.61 µM 0.051782216711574 0.484747792173139 no 1606 0.479351112773659 2290 X1361 SGTC_1261 0712-0010 12.7 µM 0.0517090453358285 0.484775960801078 no 1607 0.479380264874032 2280 2840123 SGTC_1324 1418-0026 34.4 µM 0.0514230264216152 0.48488606961802 no 1608 0.479494218306477 2228 1372513 SGTC_2369 9071472 200 µM 0.0512068236302071 0.484969302059236 no 1609 0.479580357254784 2280 17296037 SGTC_2836 9010338 19.48 µM 0.0511084601854569 0.485007169639427 no 1610 0.479619547275971 2268 2994051 SGTC_1938 st074717 56.4 µM 0.0500728976417283 0.485405844659003 no 1611 0.480032148592889 2324 17250979 SGTC_382 3229-0966 23.2 µM 0.0493271297919011 0.485692962414347 no 1612 0.48032929969077 2301 5722370 SGTC_1302 1159-0335 255 µM 0.0487829693123102 0.485902466796077 no 1613 0.480546127267007 2289 649284 SGTC_1979 st071809 45.3 µM 0.0487682187184146 0.485908145899555 no 1614 0.480552004906788 2290 4976333 SGTC_3088 9117578 49.47 µM 0.0486633288679971 0.485948529461962 no 1615 0.480593800278505 2314 678341 SGTC_2380 9035439 200 µM 0.0476583573324003 0.486335460041517 no 1616 0.480994261200503 2287 6462575 SGTC_159 3970-0959 50 µM 0.0471361064384213 0.486536540332865 no 1617 0.481202375265517 2306 6615653 SGTC_2336 9001819 198.65 µM 0.046669353515459 0.486716255348088 no 1618 0.481388378036149 2291 2989602 SGTC_1401 3807-4679 7.6 µM 0.0464523991198524 0.486799790748276 no 1619 0.481474836549132 2319 3291456 SGTC_2317 5986382 200 µM 0.0455489656261937 0.487147651967287 no 1620 0.481834873223361 2296 877883 SGTC_1493 4348-0038 111 µM 0.0454029002093084 0.487203894435872 no 1621 0.481893084670282 2317 800424 SGTC_3161 9100388 49.47 µM 0.0439053354846713 0.487780546008085 no 1622 0.4824899311511 2295 25236368 SGTC_2027 5150920 200 µM 0.0425294289068447 0.488310374498717 no 1623 0.483038326046331 2297 786715 SGTC_755 1995-0008 37.3 µM 0.041921375169796 0.488544527979327 no 1624 0.483280688226712 2325 689533 SGTC_1691 st019933 84.6 µM 0.039858989837861 0.489338754320404 no 1625 0.484102773235214 2342 6176082 SGTC_1221 2958-7315 257 µM 0.0394400662337949 0.489500087423907 no 1626 0.484269768255122 2305 4562705 SGTC_1922 5578187 25 µM 0.0391401033695885 0.489615608206581 no 1627 0.484389343793105 2336 1350412 SGTC_2433 5607874 27.82 µM 0.0389291460517709 0.489696851967229 no 1628 0.484473439493585 2336 2252428 SGTC_2127 5253358 187.912 µM 0.0383885252451668 0.489905057484179 no 1629 0.48468895488372 2328 20612 SGTC_3236 9132701 49.47 µM 0.0381745825591001 0.489987452500087 no 1630 0.484774243149699 2303 24282524 SGTC_2480 5767542 37.17 µM 0.0379868308111928 0.490059761041581 no 1631 0.484849090970451 2320 2867358 SGTC_292 k038-0015 474 µM 0.0375915191448169 0.490212007879985 no 1632 0.485006684943088 2317 46368540 SGTC_2508 celastrol 40.54 µM 0.0363516904423888 0.490689513687241 no 1633 0.485500967068828 2342 122724 Celastrol is a natural product and antioxidant. SGTC_3220 9131269 49.47 µM 0.0362843408342314 0.490715453004797 no 1634 0.485527817961105 2363 17722206 SGTC_2847 9005661 71.43 µM 0.0359441801514843 0.490846464549888 no 1635 0.485663433972187 2347 2991449 SGTC_2929 9013348 24.6 µM 0.0350515934433741 0.491190245458436 no 1636 0.486019300252978 2325 2995952 SGTC_160 3453-0671 289.699 µM 0.0346318545802955 0.491351910694522 no 1637 0.486186650223236 2333 5322268 SGTC_3312 9133330 71.43 µM 0.0338646061141489 0.491647425235904 no 1638 0.48649255860955 2319 17617324 SGTC_2576 guaiol 23.12 µM 0.0337458937129829 0.491693149091588 no 1639 0.486539890952247 2344 227829 SGTC_2834 9001755 58.44 µM 0.0309732789692414 0.492761092873982 no 1640 0.487645424869352 2249 2989575 SGTC_1873 rapamycin 2 nM 0.0303608483761678 0.492996993511491 no 1641 0.487889634460172 2344 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_38 0929-0051 58.268 µM 0.0303163373929881 0.493014138684356 no 1642 0.487907383603 2343 1379719 SGTC_1619 st003326 88.7 µM 0.0301820184018456 0.493065877056192 no 1643 0.487960944617475 2362 2849032 SGTC_2942 9052777 62.25 µM 0.0293689080373632 0.493379081736587 no 1644 0.488285184947504 2340 6469503 SGTC_1613 st002381 52.1 µM 0.0290905251359591 0.493486313918128 no 1645 0.488396196223822 2361 551167 SGTC_1310 1188-0297 994 nM 0.0290573552403298 0.493499090884783 no 1646 0.488409423505972 2329 1588352 SGTC_1800 st050079 29.0735 µM 0.0282956662683058 0.493792493513989 no 1647 0.488713168517228 2337 3645560 SGTC_2910 7948405 25.97 µM 0.0263499852584761 0.494541984805878 no 1648 0.489489093131674 2336 2971328 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.0257830205774351 0.494760387705048 no 1649 0.489715202481937 2296 689007 SGTC_645 0845-0943 5.41 µM 0.0249897550458378 0.495065967547871 no 1650 0.490031567673628 2336 1885106 SGTC_1709 st033179 39.1045 µM 0.0243519857968651 0.495311649594217 no 1651 0.490285923369062 2371 573381 SGTC_3079 9117512 49.47 µM 0.0236469679475577 0.495583239272714 no 1652 0.49056710380367 2374 7185044 SGTC_2186 6124449 200 µM 0.0234893511094714 0.495643957319733 no 1653 0.490629966363236 2353 3834182 YLR033W RSC58 SGTC_757 1066-0008 322 µM 0.0234429557905309 0.495661830005361 no 1654 0.490648470322173 2351 6842497 SGTC_1881 5652484 16 µM 0.0231656052722232 0.49576867283141 no 1655 0.490759087128571 2355 2255129 SGTC_1352 1496-0991 99 µM 0.0228114211331119 0.495905114460222 no 1656 0.490900348824633 2351 3000039 SGTC_1826 st055655 41.6 µM 0.0226820497076147 0.495954952069163 no 1657 0.490951947205515 2285 676168 SGTC_2205 7238770 200 µM 0.0222316675792216 0.496128452758073 no 1658 0.491131578376697 2359 279867 SGTC_1874 staurosporine 7.6 µM 0.02167412151305 0.496343237217158 no 1659 0.491353953481858 2366 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2913 7966556 36.57 µM 0.0215300723322637 0.496398729713152 no 1660 0.491411407383468 2367 2976516 SGTC_2621 lithochol-11-enic acid 100 µM 0.0207820481315397 0.496686894405654 no 1661 0.491709759081515 2370 6708711 SGTC_2611 pyromycin 23.93 µM 0.0205226099840512 0.496786839329443 no 1662 0.491813237857237 2357 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2015 5119600 184 µM 0.020117743383109 0.496942808934903 no 1663 0.491974722918366 2359 2828786 SGTC_1081 sertraline 6 µM 0.0199709621912169 0.496999354601479 no 1664 0.492033268379463 2372 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1481 3346-2004 36 µM 0.0199442903351768 0.497009629615696 no 1665 0.492043906791647 2369 2770522 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.0186731497706682 0.497499323524646 no 1666 0.492550923949465 2377 66535 A nucleotide analog. SGTC_526 4469-0568 170 µM 0.0181845606851641 0.497687548518266 no 1667 0.492745809694855 2369 2901964 SGTC_1409 3909-8004 61.9 µM 0.0175910476070403 0.49791619531988 no 1668 0.492982549273985 2351 2119279 SGTC_2486 5283202 22.39 µM 0.0175786401262692 0.497920975223457 no 1669 0.492987498377401 2348 1377751 SGTC_315 k915-0449 187 µM 0.0174194361993831 0.497982307556684 no 1670 0.493051001831333 2343 20970215 YNL149C PGA2 SGTC_59 0330-0160 1.33 µM 0.0171252518588041 0.498095640388134 no 1671 0.49316834689729 2317 4293482 SGTC_3311 9131146 2.8755 µM 0.0161883594591936 0.498456573796169 no 1672 0.493542061027081 2327 4900406 YPR165W RHO1 SGTC_1188 1403-0014 4.57 µM 0.0161491181501239 0.498471691356285 no 1673 0.493557713998209 2369 9614867 SGTC_886 0866-0150 153 µM 0.0157759531596518 0.498615451809058 no 1674 0.493706566324426 2378 271463 SGTC_2699 st077704 54.6 µM 0.0151637582533736 0.498851298046666 no 1675 0.493950767530145 2372 645852 SGTC_3314 9135860 59.4275 µM 0.0140586122746793 0.499277053155738 no 1676 0.494391609905118 2374 25252478 SGTC_938 3126-1755 342 µM 0.0121820405509218 0.5 no 1677 0.495140189164002 2380 1777771 SGTC_2008 4012253 172 µM 0.0118633135577851 0.499877210770348 no 1678 0.495267333647564 2376 603940 SGTC_2933 9026794 32.47 µM 0.0116255014915035 0.499785593935757 no 1679 0.495362200392607 2377 17586027 SGTC_3343 9148379 18.9835 µM 0.0116014081075743 0.49977631198689 no 1680 0.495371811613968 2389 1955036 SGTC_51 1013-0126 23.419 µM 0.0113146618786259 0.499665843337688 no 1681 0.49548619929902 2393 1627850 SGTC_651 3253-0966 34.4 µM 0.0105626338618017 0.499376125567574 no 1682 0.4957861971154 2384 781462 SGTC_2759 disulfiram 3.38 µM 0.00843206208753964 0.498555327984308 no 1683 0.496636133783988 2382 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_883 0850-0245 24.6 µM 0.00831714383982384 0.498511056152139 no 1684 0.496681977924122 2371 6823229 YPR165W RHO1 SGTC_3327 9140648 26.9345 µM 0.00756371916753988 0.498220802548058 no 1685 0.496982541398404 2381 8029710 SGTC_910 3454-3003 490 µM 0.00740040238774456 0.498157885582242 no 1686 0.497047693543217 2393 820824 SGTC_2468 5987765 72.9 µM 0.00673040672339509 0.497899773627795 no 1687 0.497314976464955 2362 26772094 SGTC_763 3453-1109 128 µM 0.00626548739512963 0.497720666655884 no 1688 0.497500448524642 2393 1560353 SGTC_797 k781-0471 270 µM 0.00564367841364023 0.497481119749187 no 1689 0.497748510015891 2367 23738129 SGTC_1080 nisoldipine 24.4 µM 0.00560457670745207 0.497466056160961 no 1690 0.497764109093016 2399 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_301 4119-0100 24.5 µM 0.00504496630511421 0.497250471584156 no 1691 0.497987358175214 2392 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1472 k841-0093 193 µM 0.00353024841995812 0.496666945155396 no 1692 0.498591637570281 2395 X1472 SGTC_1049 3226-0134 66 µM 0.00297101932941067 0.496451510764856 no 1693 0.49881473651732 2396 5702385 SGTC_2875 9039966 71.43 µM 0.00252624015375092 0.496280167176357 no 1694 0.49899217706419 2391 6463691 SGTC_592 k241-0073 46.5 µM 0.00242447058924762 0.496240962283376 no 1695 0.499032777121925 2402 4230158 SGTC_2217 6934799 96.0675 µM 0.00236573792760629 0.496218336599101 no 1696 0.499056207996685 2397 675606 SGTC_435 c-PAF 6.7 µM 0.00234250233987375 0.496209385517023 no 1697 0.499065477629355 2401 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_877 0771-0151 33.1 µM 0.00212125358612737 0.496124153607209 no 1698 0.499153742891694 2387 6166523 SGTC_136 0097-0015 404.482 µM 0.00209725195242229 0.496114907441043 no 1699 0.499163318136877 2395 4861337 SGTC_1666 st014829 29 µM 0.000675166718786446 0.495567080447515 no 1700 0.49973064747002 2402 3858230 SGTC_167 3672-0051 66.205 µM 0.000501442405634559 0.495500157537024 no 1701 0.49979995343159 2404 3237971 SGTC_1170 0310-0127 64.8 µM 2.74935186936445e-05 0.495317581330377 no 1702 0.499989031672957 2402 774975 SGTC_95 0471-0001 561.058 µM 0 0.495306990213067 no 1703 0.5 2406 4015405 SGTC_2196 6573537 42.6665 µM 0 0.495306990213067 no 1704 0.5 2406 2903087 SGTC_1100 amiodarone 5.07 µM -0.000902157247407075 0.494959460975944 no 1705 0.49964009137926 2409 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_718 1130-0073 349 µM -0.00119701082911481 0.494845878223172 no 1706 0.499522461884207 2408 6740020 SGTC_3356 9151811 4.48 µM -0.0015479949527906 0.494710673550134 no 1707 0.499382439610126 2410 1859254 YPR165W RHO1 SGTC_2130 NSC 7 2.4545 µM -0.00187638137831233 0.494584174420112 no 1708 0.499251432573294 2412 21448 SGTC_2816 7982706 58.44 µM -0.00200854746093056 0.494533262314944 no 1709 0.499198706034414 2416 2981853 SGTC_421 streptovitacin 30 mM -0.00294670657464989 0.494171873750975 no 1710 0.498824435860688 2439 91467 include heat shock SGTC_753 1322-0200 289 µM -0.00492057566582755 0.493411534999503 no 1711 0.498036982244442 2426 5403907 SGTC_2596 sinensetin 100 µM -0.00512964682214361 0.493331001680103 no 1712 0.497953575973811 2420 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_671 0560-0003 407 µM -0.00639560884145052 0.492843364423544 no 1713 0.497448538618331 2424 3238678 SGTC_1524 corynanthine 62.1 µM -0.00648253257527661 0.49280988256214 no 1714 0.497413861784635 2486 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1392 3455-1037 33.9 µM -0.00685413907414368 0.492666745275659 no 1715 0.497265615537465 2421 981132 SGTC_3299 9121982 43.1275 µM -0.00733800224017648 0.492480369811543 no 1716 0.497072586924453 2422 17594604 YPL160W CDC60 SGTC_1337 1486-1011 40.3 µM -0.00866030719191859 0.491971050013835 no 1717 0.496545080486957 2421 X1337 SGTC_1660 st012960 28.1 µM -0.00948679293921978 0.491652714343502 no 1718 0.496215373960128 2429 24207266 SGTC_1098 clofazimine 15.1 µM -0.00960805429878476 0.491606008818707 no 1719 0.496166999881627 2451 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_523 1934-0222 13.7 µM -0.00981330077795569 0.491526955501844 no 1720 0.496085122243835 2433 1361595 SGTC_580 1123-0028 41 µM -0.0104694737528948 0.49127422430314 no 1721 0.495823360566715 2425 1677248 YPR107C YTH1 SGTC_128 0906-2981 13.371 µM -0.0106067912624453 0.491221335611443 no 1722 0.495768581848093 2424 6740226 SGTC_791 1348-1292 225 µM -0.0106373887020873 0.491209550838514 no 1723 0.495756375924357 2466 5437054 SGTC_40 0327-0103 19.753 µM -0.0111898531101032 0.490996767449523 no 1724 0.495535987641683 2433 409036 SGTC_2364 9055074 200 µM -0.0127342531280601 0.490401950752436 no 1725 0.494919905317298 2441 6470630 SGTC_2113 5491891 107.031 µM -0.0135063212608042 0.490104601114903 no 1726 0.494611921213075 2431 789979 SGTC_1192 1488-0095 21.4 µM -0.0135578030146712 0.490084773938241 no 1727 0.494591384845153 2456 915875 SGTC_2281 7943571 200 µM -0.0136554685190085 0.490047160073239 no 1728 0.49455242555279 2429 1244024 SGTC_624 k048-0052 28 µM -0.0150746589840883 0.489500598143993 no 1729 0.493986308933358 2442 6835531 SGTC_2019 4016004 108 µM -0.0151712979768804 0.489463381015938 no 1730 0.493947759961627 2458 45595336 SGTC_2165 5727197 32.143 µM -0.0154866139094522 0.489341948752623 no 1731 0.493821981883299 2504 1361712 SGTC_2641 levomentholum 100 µM -0.0160849909927992 0.489111508687214 no 1732 0.493583293710081 2423 16666 SGTC_2998 9066762 71.4286 µM -0.0166692304595387 0.488886516643638 no 1733 0.493350247143011 2452 4945196 SGTC_3280 9140961 49.47 µM -0.0168655996204841 0.48881089519137 no 1734 0.493271918193986 2436 4901226 SGTC_2210 7115885 190.385 µM -0.0176511801511292 0.488508373426222 no 1735 0.492958563583835 2433 2927039 SGTC_1766 st045414 44.774 µM -0.0179757452942137 0.488383387498325 no 1736 0.492829101368152 2439 253960 SGTC_873 0591-4978 488 µM -0.0180431905224903 0.488357415337472 no 1737 0.492802198978113 2436 3305145 SGTC_1255 0566-0045 221 µM -0.0181667492549139 0.488309834823448 no 1738 0.492752914253848 2468 2788469 SGTC_2277 7947813 106.88 µM -0.0183781320596755 0.488228435034106 no 1739 0.492668598792722 2534 1246798 SGTC_2166 5933061 31.504 µM -0.0189243784887263 0.488018087449135 no 1740 0.492450715900047 2468 2877375 SGTC_646 4092-0839 27.3 µM -0.0196752044090686 0.487728966215475 no 1741 0.492151235482953 2455 877796 SGTC_513 4245-1575 41.7 µM -0.0202703284728822 0.487499805814249 no 1742 0.491913862685395 2486 719745 SGTC_218 alverine citrate 93.75 µM -0.0203013375755672 0.487487865461118 no 1743 0.491901494388389 2458 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_740 k014-0057 261 µM -0.0205235965051109 0.487402282852291 no 1744 0.491812844375151 2472 4012779 SGTC_1857 st056007 79.3 µM -0.0206569965797424 0.487350916346727 no 1745 0.491759636725373 2448 619834 SGTC_967 1306-0166 352 µM -0.0214212055082503 0.487056657146925 no 1746 0.491454828948245 2444 4437607 SGTC_2779 methotrexate 400 µM -0.0214327824877357 0.487052199476393 no 1747 0.491450211461751 2441 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1012 4112-3522 18 µM -0.0222832859220693 0.486724720927318 no 1748 0.491110990737434 2449 3112398 SGTC_1860 st056228 74.6 µM -0.0222979317111494 0.486719081778288 no 1749 0.491105149364326 2507 688679 SGTC_2806 7952793 58.44 µM -0.0223163680619315 0.486711983132134 no 1750 0.491097796154242 2474 2972490 SGTC_2549 cedrol 20.94 µM -0.0232547976743511 0.486350660200323 no 1751 0.490723514091411 2455 6708665 A sedative which affects the nervous system. SGTC_1227 3909-8010 46.6 µM -0.0236398528946485 0.486202405869184 no 1752 0.490569941505839 2463 15982272 SGTC_2234 tolnaftate 200 µM -0.0240997933464202 0.486025321655266 no 1753 0.490386504080651 2441 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1086 cerivastatin 2.18 µM -0.0242703397651212 0.485959659335042 no 1754 0.490318485798991 2453 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1353 1498-1206 8.11 µM -0.024285542032972 0.485953806306638 no 1755 0.490312422758685 2445 6756808 SGTC_1771 st048882 4.1505 µM -0.024437101413468 0.485895454562735 no 1756 0.49025197725295 2445 4580403 SGTC_1338 1486-1223 76 µM -0.0248115841166461 0.485751276603861 no 1757 0.490102625557428 2493 3444526 SGTC_978 1416-0512 87.4 µM -0.0255021014792079 0.485485428411147 no 1758 0.489827236147808 2478 6814003 SGTC_589 1227-0070 34.1 µM -0.0263013522562309 0.485177726072445 no 1759 0.489508488170549 2476 2841384 SGTC_2892 9047358 58.44 µM -0.0281372543969708 0.484470958624316 no 1760 0.48877634055755 2474 6466771 SGTC_2063 5246145 200 µM -0.0288851481065875 0.484183055760222 no 1761 0.488478095387173 2489 711240 SGTC_114 0364-0001 490.298 µM -0.0289393311707185 0.484162198222691 no 1762 0.488456488504686 2480 4003655 SGTC_677 0929-0063 136 µM -0.0291274236337842 0.484089793174603 no 1763 0.48838148208816 2463 1539583 SGTC_1761 st044296 37 µM -0.0299890274393688 0.483758130779373 no 1764 0.488037902035572 2458 1826700 SGTC_488 nitrendipine 139 µM -0.0303227631891596 0.483629666853459 no 1765 0.487904821259242 2442 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2251 lansoprazole 556 µM -0.0310368290045151 0.483354809312687 no 1766 0.487620084256428 2472 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2889 9059656 51.95 µM -0.0313468574381854 0.483235475915178 no 1767 0.487496460959709 2498 3949838 SGTC_1673 st016611 27.3 µM -0.0321722812213154 0.482917768457282 no 1768 0.487167330556595 2536 5226799 SGTC_67 0335-0847 266 µM -0.0330801322698133 0.482568347094031 no 1769 0.486805343115018 2534 4552207 YOR254C SEC63 SGTC_1461 k072-0203 53.8 µM -0.0337882499103183 0.482295810089279 no 1770 0.486523002905042 2444 5418714 SGTC_1381 2324-0066 62.1 µM -0.0344075385894197 0.48205746793669 no 1771 0.486276086053811 2509 10885928 SGTC_1497 4476-2978 41.3 µM -0.0358553590824738 0.481500278571295 no 1772 0.485698845625487 2528 1528379 SGTC_4 0960-0234 25.671 µM -0.036074575511637 0.481415916910536 no 1773 0.485611447465628 2461 6821112 SGTC_2436 5633522 8.09 µM -0.0364918983355617 0.481255319724853 no 1774 0.485445069300051 2485 5724242 SGTC_1079 idarubicin 2.36 µM -0.0385145303360964 0.480476999431976 no 1775 0.484638723273385 2470 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_270 tamoxifen 5.46 µM -0.0400324432389005 0.479892946637504 no 1776 0.484033630526096 2476 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2949 9072542 2.23 µM -0.0401636668612904 0.479842457262666 no 1777 0.483981321944164 2514 16457352 SGTC_77 0828-0286 12.516 µM -0.0404380197191165 0.479736898775698 no 1778 0.483871959836511 2473 745345 SGTC_1134 3477-0009 42.5 µM -0.041580288867181 0.479297420979997 no 1779 0.483416643427851 2513 3973534 SGTC_3003 9075612 71.4286 µM -0.0418895633409045 0.479178434711139 no 1780 0.483293368171959 2533 6501993 SGTC_3054 9094397 49.47 µM -0.0432236690756372 0.478665189491277 no 1781 0.482761618761855 2498 2598354 SGTC_2958 9077254 16.72 µM -0.043437551543601 0.47858290981045 no 1782 0.482676372067201 2533 16457351 SGTC_293 4049-0273 38.5 µM -0.0438326055604558 0.478430936603575 no 1783 0.482518918286813 2480 1380311 SGTC_1783 st039459 87.517 µM -0.0438667081990243 0.478417817816878 no 1784 0.48250532637591 2564 729761 SGTC_1393 3470-5649 58.2 µM -0.0449742839223674 0.47799176241486 no 1785 0.482063903332229 2545 4108395 SGTC_2247 cerulenin 830 nM -0.0450414499938007 0.477965926188481 no 1786 0.482037135072606 2612 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_151 3013-0144 2.285 µM -0.0456045147061142 0.477749340317997 no 1787 0.481812735351518 2626 906558 YHR107C CDC12 SGTC_251 melphalan 456.522 µM -0.0462578958734016 0.477498021978832 no 1788 0.481552348793797 2516 460612 A DNA alkylator. SGTC_2488 5268135 45.7 µM -0.0464419361627913 0.477427233823918 no 1789 0.481479006165017 2522 1270356 YLR208W SEC13 SGTC_2753 fluvastatin 17.09 µM -0.0468975058425655 0.477252009298405 no 1790 0.481297457979031 2547 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2612 dictamnine 15.46 µM -0.0470533005436877 0.47719208741416 no 1791 0.481235373424194 2536 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_3051 9093778 49.47 µM -0.0493070521080703 0.476325306027215 no 1792 0.480337299792998 2497 17217378 SGTC_2995 9067767 71.4286 µM -0.0494394479508051 0.47627439070287 no 1793 0.480284545832457 2537 11673567 SGTC_1782 st039423 80.636 µM -0.0495423719626879 0.476234809595835 no 1794 0.480243535347752 2514 2068169 SGTC_1939 st074455 53.6 µM -0.050243346043874 0.475965244839805 no 1795 0.479964235002251 2497 1644229 SGTC_1036 k216-0215 33.5 µM -0.0507901240081821 0.475754984968552 no 1796 0.479746380310534 2496 622330 SGTC_914 3820-6779 408 µM -0.0515149765508096 0.475476258105888 no 1797 0.479457584067529 2505 2893481 SGTC_2218 6965428 192.983 µM -0.0528399027184654 0.474966816611645 no 1798 0.478929734060584 2511 675684 SGTC_2948 9070189 9.45 µM -0.0528685298993598 0.474955809749765 no 1799 0.478918329408724 2524 6473636 YDL196W YDL196W SGTC_1812 st052057 4.327 µM -0.0531551694674015 0.474845600786558 no 1800 0.478804137333463 2491 3645418 SGTC_39 0986-0283 58.349 µM -0.0535874985299102 0.474679379864219 no 1801 0.478631908464392 2529 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2024 5144227 134 µM -0.0541886594020783 0.474448254192336 no 1802 0.478392427948056 2544 3475211 SGTC_2339 9000433 200 µM -0.0543414467136955 0.474389514095253 no 1803 0.478331564308063 2550 2988954 SGTC_948 3448-0295 75.3 µM -0.0556271023619437 0.473895257417078 no 1804 0.477819436682726 2522 678569 SGTC_956 1185-0240 191 µM -0.0558992580803818 0.473790635165113 no 1805 0.477711030936797 2538 1416193 SGTC_2763 lisinopril 49.32 µM -0.0563991936633033 0.473598454367033 no 1806 0.477511899649054 2491 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_986 1493-0483 84 µM -0.0596433578111413 0.47235151287723 no 1807 0.476219842637542 2496 40079 SGTC_2852 9023854 51.95 µM -0.0599698361983155 0.472226040981114 no 1808 0.476089829331565 2579 19798528 SGTC_590 k048-0076 22.4 µM -0.0625145415201981 0.47124815742306 no 1809 0.47507654106562 2549 6832814 SGTC_1510 1123-0200 71.5 µM -0.0626947444152964 0.47117891525975 no 1810 0.47500479125567 2597 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_613 3914-0030 117 µM -0.0627302975198633 0.471165254239821 no 1811 0.474990635482785 2480 1145395 SGTC_2924 9010168 62.78 µM -0.063842739382061 0.470737823826847 no 1812 0.474547723273291 2598 2993929 SGTC_1020 4335-0961 93.3 µM -0.0662367710743695 0.469818086720814 no 1813 0.473594660978679 2513 669075 SGTC_2570 licareol 100 µM -0.0662395187170936 0.46981703122528 no 1814 0.473593567229866 2610 443158 SGTC_319 1348-1596 45.5 µM -0.0686418471262275 0.468894268729969 no 1815 0.472637354106053 2642 5380505 SGTC_2036 5160441 105 µM -0.0686971216778512 0.4688730390742 no 1816 0.472615354680702 2550 134534 YIL048W NEO1 SGTC_1643 st009866 20.2 µM -0.0691002189931617 0.468718221552226 no 1817 0.472454923357743 2534 3156273 YOR207C RET1 SGTC_1633 st005664 67.9 µM -0.0706157365962748 0.468136199462011 no 1818 0.471851792843495 2521 2063822 SGTC_2653 dihydrofissinolide 100 µM -0.0730782722518023 0.467190628646059 no 1819 0.470871915825694 2572 6857746 SGTC_3257 9139206 32.98 µM -0.073443882408753 0.467050256365242 no 1820 0.470726449373732 2555 4910041 SGTC_2822 7994718 71.43 µM -0.0754182764462762 0.466292279224547 no 1821 0.469940959059991 2533 1018011 SGTC_31 0508-1974 57.237 µM -0.0771486613694364 0.465628078503573 no 1822 0.469252641073636 2549 6810525 SGTC_2804 7954240 19.48 µM -0.0782466133923829 0.46520668392704 no 1823 0.468815941763134 2612 828705 SGTC_330 1488-0319 80.1 µM -0.0792165980582795 0.464834435734074 no 1824 0.468430171369249 2608 6846614 SGTC_895 0964-0006 13.7 µM -0.0792534150037109 0.464820307206198 no 1825 0.468415529567277 2526 6738897 SGTC_1245 0418-0076 17.2 µM -0.0793792158931035 0.464772031364045 no 1826 0.46836549989168 2648 6790114 SGTC_372 0155-0182 15.9 µM -0.0800354775303687 0.46452020068487 no 1827 0.468104519737938 2549 771486 SGTC_2006 4011487 200 µM -0.0800378163054003 0.464519303239961 no 1828 0.468103589685364 2610 45595294 SGTC_1114 scopoletin 1.73284 µM -0.0801432606334315 0.464478841872204 no 1829 0.468061658185282 2540 5280460 A coumarin with genotoxic properties. SGTC_605 1315-0399 119 µM -0.0803708109024443 0.464391526952072 no 1830 0.4679711706558 2636 24020461 SGTC_380 3970-0968 6 µM -0.0807677087273685 0.464239234592194 no 1831 0.467813344422737 2560 2891601 SGTC_3228 9131799 49.47 µM -0.0810703253414103 0.464123122084839 no 1832 0.467693012466752 2592 17015818 SGTC_1167 k781-0610 148 µM -0.0819431291976272 0.463788248685145 no 1833 0.467345968799348 2595 4525169 SGTC_1637 st007924 17.4 µM -0.0833821228387631 0.46323619829822 no 1834 0.466773851457079 2553 683336 SGTC_189 3970-0742 2.116 µM -0.0842985771018871 0.462884649885561 no 1835 0.466409521842629 2561 2891807 SGTC_3074 9116018 49.47 µM -0.0847340830137319 0.462717601596875 no 1836 0.466236399535043 2548 17027303 SGTC_852 0418-0143 439 µM -0.0875932681295634 0.46162106014457 no 1837 0.465099976434173 2572 5369229 SGTC_1680 diphenhydramine 100 µM -0.0879231364581407 0.461494569178172 no 1838 0.464968883789854 2629 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1935 st074532 41.6 µM -0.088016576616105 0.461458739419705 no 1839 0.464931750520041 2701 2829742 SGTC_3170 9103054 49.47 µM -0.0882146103319408 0.461382804150479 no 1840 0.464853052611148 2623 16432970 SGTC_1181 1222-0449 220 µM -0.0887973171475113 0.461159375632032 no 1841 0.464621494938001 2668 658318 SGTC_1504 k297-0033 30 µM -0.088924872556424 0.461110468422345 no 1842 0.464570808206566 2537 4388117 SGTC_1561 5-methoxyflavone 52.9 µM -0.0892526489185762 0.460984795327947 no 1843 0.464440562253214 2552 94525 SGTC_2402 5553605 200 µM -0.0898530461553422 0.460754606479271 no 1844 0.46420199694709 2656 6758546 SGTC_389 tpck 16.7 µM -0.0905380207333705 0.460492007227622 no 1845 0.463929840913293 2610 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_3198 9112019 49.47 µM -0.0914572736678354 0.460139619592108 no 1846 0.463564627287547 2574 45595555 SGTC_2283 7944793 200 µM -0.0916869761353985 0.460051570022391 no 1847 0.463473372670425 2612 2970533 SGTC_3304 9125678 46.087 µM -0.0921907540752389 0.459858468684596 no 1848 0.463273241970192 2599 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_3100 9120536 49.47 µM -0.0926680380661004 0.459675531382128 no 1849 0.463083644823016 2542 16421196 SGTC_2134 5324836 1.464 µM -0.0938701710281832 0.459214805967017 no 1850 0.462606144626953 2617 699272 SGTC_1907 st060210 83.7 µM -0.0955844389997226 0.458557896312321 no 1851 0.461925312242734 2601 688793 SGTC_1416 3966-0321 25.3 µM -0.0956242369521714 0.458542647023766 no 1852 0.461909507551067 2607 582530 YLR208W SEC13 SGTC_1548 st061468 90.8 µM -0.095626909877926 0.458541622847229 no 1853 0.461908446072296 2598 390799 SGTC_1508 1080-0625 72.9 µM -0.0965963976515692 0.458170165479639 no 1854 0.461523458687645 2547 767111 SGTC_2003 4023581 200 µM -0.0991641449108323 0.457186515429268 no 1855 0.460503971358306 2671 16641307 SGTC_739 1486-1183 203 µM -0.0994466584345887 0.457078306335651 no 1856 0.460391819132972 2576 4346692 SGTC_3255 9139072 49.47 µM -0.0997505229990465 0.456961922861022 no 1857 0.460271194488311 2646 17646060 SGTC_909 3448-9333 149 µM -0.0998809672864353 0.456911962394245 no 1858 0.46021941334296 2582 3344074 SGTC_2770 toltrazuril 17.5 µM -0.10008210156145 0.456834928832004 no 1859 0.460139572432824 2578 68591 Kills coccidiodes. SGTC_527 4476-4215 268 µM -0.100305325847643 0.45674943678967 no 1860 0.460050964702075 2595 4418754 SGTC_1755 st041960 45.185 µM -0.101344710318919 0.456351392274563 no 1861 0.459638412584892 2680 2257073 SGTC_2096 5468907 200 µM -0.10164673673706 0.456235735898203 no 1862 0.459518540494256 2687 759785 SGTC_2588 indole-3-carbinol 100 µM -0.101704644647554 0.45621356137691 no 1863 0.459495557685473 2678 3712 Induces cell cycle arrest. SGTC_1331 1472-0049 76.2 µM -0.102332100742068 0.455973300051455 no 1864 0.459246538168195 2585 24051409 SGTC_286 k060-0067 22.9 µM -0.10299678080383 0.455718802732226 no 1865 0.458982762956488 2612 5985051 SGTC_1841 st054148 70 µM -0.103365800666652 0.455577517680539 no 1866 0.458836326916914 2645 675442 SGTC_2496 diffractaic acid 79.83 µM -0.105050338889475 0.454932637379982 no 1867 0.4581679325009 2660 94870 An apoptosis inducer which activates caspases. SGTC_1974 st069448 26.9 µM -0.105475789194782 0.454769783852528 no 1868 0.457999140118544 2654 6323587 YNR016C ACC1 SGTC_2070 5230947 200 µM -0.105488548777103 0.454764899867092 no 1869 0.457994078021836 2593 2835538 SGTC_850 0388-0143 75.9 µM -0.107063286608973 0.454162190182825 no 1870 0.457369386376364 2609 67273 SGTC_2185 6113692 200 µM -0.107570523190093 0.453968074621639 no 1871 0.457168190182405 2691 874150 SGTC_1406 3909-7906 11.9 µM -0.107705863584725 0.453916282743814 no 1872 0.457114509053519 2627 X1406 SGTC_1030 k029-0042 36.7 µM -0.108559714682751 0.453589550272192 no 1873 0.456775857434304 2653 6080581 SGTC_1560 lithocholic acid 53.1 µM -0.108974358222746 0.453430895155249 no 1874 0.456611414182481 2597 9903 A bile acid which acts as a detergent. SGTC_1587 estradiol valerate 56.1 µM -0.109153732193297 0.453362263568869 no 1875 0.456540278659651 2609 13791 A steroid. SGTC_3036 9090181 49.47 µM -0.110056067657158 0.453017035569029 no 1876 0.45618245468366 2590 25236586 SGTC_1759 st043059 70 µM -0.110326322946789 0.452913644455285 no 1877 0.456075290997423 2621 669426 SGTC_808 0711-0032 135 µM -0.110750601072733 0.452751335524939 no 1878 0.455907059451304 2575 4252555 SGTC_2409 alverine citrate 63.97 µM -0.110876119053668 0.452703319738865 no 1879 0.455857291526889 2898 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1217 1183-1422 255 µM -0.111624243019651 0.452417145946165 no 1880 0.455560674499533 2712 2849664 SGTC_3067 9117431 49.47 µM -0.112878513981064 0.451937415379833 no 1881 0.455063435402175 2657 17150885 SGTC_2312 7706453 155.7 µM -0.113215512108706 0.451808533069879 no 1882 0.454929848926911 2639 976098 SGTC_3119 9125183 49.47 µM -0.113406999261988 0.451735302561045 no 1883 0.45485394545196 2585 22695334 SGTC_3125 9127534 49.47 µM -0.113546579763586 0.451681923768535 no 1884 0.454798618261247 2588 1639235 SGTC_828 2074-0507 139 µM -0.114277978427899 0.451402234409216 no 1885 0.454508719396287 2715 X828 SGTC_744 1594-0068 283 µM -0.114796223043233 0.451204070483586 no 1886 0.454303321420349 2621 668392 SGTC_1669 st015249 58.4 µM -0.115051798915349 0.451106349064107 no 1887 0.45420203250098 2652 722793 SGTC_2728 chlorpromazine 9.18 µM -0.11638809657906 0.450595453660839 no 1888 0.453672484416675 2594 2726 A thorazine and dopamine antagonist. SGTC_2037 5169046 200 µM -0.116725388564003 0.450466512567686 no 1889 0.453538835317232 2714 5718022 SGTC_499 genistein 192 µM -0.117091180600318 0.450326682290467 no 1890 0.453393899261106 2645 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_937 3122-0005 46.7 µM -0.118475408560895 0.449797593379642 no 1891 0.452845489487352 2695 759535 SGTC_1807 st050092 58.9 µM -0.118793823527598 0.449675899261236 no 1892 0.452719351072395 2628 5008496 SGTC_929 2805-0021 398 µM -0.118901078778417 0.449634908744324 no 1893 0.452676863542302 2718 3098024 SGTC_1301 naphtanilide LB 4.81 µM -0.118937504309866 0.449620987857076 no 1894 0.452662434247375 2692 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_254 nsc-64875 3.808 µM -0.119002278726155 0.449596232919248 no 1895 0.452636775224876 2767 56993 SGTC_1075 aripiprazole 15.2 µM -0.121056543157626 0.44881125380045 no 1896 0.451823124746769 2607 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1744 st037937 38.9 µM -0.122874345596401 0.448116798924846 no 1897 0.451103300453112 2747 1016152 SGTC_2897 9048598 12.99 µM -0.123928623086565 0.44771410610674 no 1898 0.45068589484688 2645 6467404 SGTC_542 3381-0244 89.3 µM -0.125705935127351 0.447035364532002 no 1899 0.449982351793757 2795 1112843 SGTC_20 0481-0013 4.944 µM -0.126673087173765 0.446666081763782 no 1900 0.44959957376938 2627 182045 SGTC_1729 st035615 45.989 µM -0.127141789479905 0.44648713615182 no 1901 0.449414088302365 2787 17385451 SGTC_2520 obtusaquinone 4.71 µM -0.129074726994897 0.445749276461479 no 1902 0.448649259818922 2769 5967872 SGTC_1693 xanthone 101.9 µM -0.129203143989463 0.445700262505228 no 1903 0.448598454260176 2674 7020 An insecticide. SGTC_2106 5357045 167.29 µM -0.129852044395709 0.445452604128799 no 1904 0.448341742988099 2744 668842 SGTC_686 1319-0111 510 µM -0.130342287104313 0.445265512925858 no 1905 0.448147812572384 2737 4562600 SGTC_3135 9127742 49.47 µM -0.130429757107098 0.445232133050775 no 1906 0.448113212453488 2729 3643468 SGTC_2965 9082772 38.63 µM -0.130697024437268 0.445130142204925 no 1907 0.448007493154545 2707 16459634 SGTC_1579 chlormadinone acetate 49.4 µM -0.131125939479674 0.444966473198509 no 1908 0.447837840792501 2772 45114258 A steroidal progestin. SGTC_402 epigallocatechin gallate 10 µM -0.131709242796781 0.444743906476171 no 1909 0.447607137258936 2645 65064 An antioxidant. SGTC_414 piperonyl butoxide 100 µM -0.131766274384578 0.444722146289749 no 1910 0.447584581524455 2643 5794 A potent inhibitor of cytochrome P450. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.133101369951259 0.444212793365235 no 1911 0.447056605861897 2644 6708561 SGTC_2696 st077691 74.316 µM -0.133893821768004 0.443910508222537 no 1912 0.446743267905205 2780 757133 SGTC_1429 4049-0205 9.46 µM -0.13413843837907 0.44381720444143 no 1913 0.446646552428832 2623 22774478 SGTC_1073 triclabendazole 3.09 µM -0.134461256582187 0.443694077101009 no 1914 0.446518922797536 2695 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2534 helenine 20.12 µM -0.1352701968614 0.443385559959185 no 1915 0.446199123964377 2658 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_3194 9111903 49.47 µM -0.13678529976363 0.4428078159297 no 1916 0.445600251754254 2800 17087251 SGTC_2757 clomiphene 4.22 µM -0.136898537682394 0.442764640541751 no 1917 0.445555497357472 2774 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_848 0368-0089 85.6 µM -0.137622695181591 0.442488549644292 no 1918 0.445269309020206 2669 762535 SGTC_1311 1190-0148 100 µM -0.139728067923111 0.441686018388172 no 1919 0.444437424478063 2770 1961333 SGTC_1484 3473-2379 286 µM -0.140449211620204 0.441411185888632 no 1920 0.444152538947634 2656 671917 SGTC_80 0159-0065 512.242 µM -0.140689208277028 0.441319727869166 no 1921 0.44405773542128 2626 1548079 SGTC_799 1310-0557 151 µM -0.141509126446402 0.441007296768288 no 1922 0.44373387536622 2795 5354492 SGTC_2648 atorvastatin 78.68 µM -0.141928087453556 0.440847665181528 no 1923 0.443568404154602 2710 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1150 3909-7983 10.9 µM -0.144397676776312 0.439906903922322 no 1924 0.442593225624352 2687 23965914 SGTC_2876 9059903 25.97 µM -0.145179813966104 0.43960902835056 no 1925 0.44228445159551 2655 6916095 SGTC_190 3970-0790 3.722 µM -0.145771386699337 0.439383751614769 no 1926 0.442050932344937 2630 2832352 SGTC_638 3970-0837 4.09 µM -0.146258110475581 0.439198417112286 no 1927 0.441858816591792 2701 4118451 YLR208W SEC13 SGTC_2164 5685496 200 µM -0.14655379053572 0.439085834671403 no 1928 0.441742114775388 2673 759046 SGTC_2090 5301565 104.445 µM -0.146576057530131 0.439077356542635 no 1929 0.441733326431027 2696 2056344 SGTC_1505 k297-0037 20.6 µM -0.147697219871551 0.438650511671868 no 1930 0.441290862897337 2692 4089396 SGTC_3274 9138298 49.47 µM -0.147764362753448 0.438624951536125 no 1931 0.441264367469396 2649 17015756 SGTC_2487 5918373 44.05 µM -0.147962492584231 0.43854952842331 no 1932 0.441186184472305 2649 2876279 SGTC_334 1502-1024 68.5 µM -0.148482010161162 0.43835177157063 no 1933 0.44098119119557 2764 3296216 SGTC_384 k007-0144 5.16 µM -0.150529972680511 0.437572355229788 no 1934 0.440173252680753 2738 6824886 SGTC_3005 9076496 71.4286 µM -0.150838216301305 0.437455064350666 no 1935 0.440051669449191 2727 21368410 SGTC_2423 st077119 87.2 µM -0.151504620780593 0.437201507205135 no 1936 0.439788833028983 2606 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_3124 9127567 49.47 µM -0.151576309066202 0.43717423239691 no 1937 0.439760560049387 2829 17592030 SGTC_2254 7938975 95.19 µM -0.151837848470214 0.437074728615227 no 1938 0.439657414725862 2863 2969277 SGTC_2923 7992654 58.14 µM -0.152035034453782 0.436999710998267 no 1939 0.439579651667786 2723 2985126 SGTC_2697 mebhydrolin 72.4 µM -0.152568539189249 0.436796755328977 no 1940 0.439369268287858 2784 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1778 st046819 58.9 µM -0.15311661528817 0.436588273749884 no 1941 0.43915315663796 2685 671715 SGTC_3313 9133968 57.047 µM -0.153705923832154 0.436364127494385 no 1942 0.438920806875284 2653 1494643 SGTC_1405 3909-7894 12 µM -0.156113666428079 0.435448544400353 no 1943 0.437971713094787 2783 7104060 SGTC_1688 st021091 57.6 µM -0.156647498636078 0.435245592741854 no 1944 0.437761333060083 2671 3656366 SGTC_211 3455-0679 143.504 µM -0.158018688123282 0.434724373941653 no 1945 0.437221036367052 2742 748649 SGTC_2043 5101342 149 µM -0.158470277456215 0.434552739847435 no 1946 0.437043119925298 2709 678451 SGTC_2112 5488546 200 µM -0.158887971628519 0.43439399915653 no 1947 0.436878568778121 2683 600757 SGTC_3165 9101544 49.47 µM -0.159627643439826 0.434112919896832 no 1948 0.436587200942309 2793 5002184 SGTC_1914 st062367 72.6 µM -0.159719516141233 0.434078010099678 no 1949 0.436551013303942 2717 978205 SGTC_2379 9035213 200 µM -0.159968942294727 0.433983235721393 no 1950 0.436452769786448 2712 646551 SGTC_3027 9089541 49.47 µM -0.160608977077991 0.433740059278339 no 1951 0.436200692004454 2784 9943819 SGTC_2049 5262831 67.185 µM -0.161062238832568 0.433567861017709 no 1952 0.436022190470397 2739 763417 SGTC_1772 st048439 82.2 µM -0.161536582230596 0.43338766715205 no 1953 0.435835400611538 2750 2927068 YDL195W SEC31 SGTC_1279 0874-0590 65.2 µM -0.161995052775264 0.433213516234221 no 1954 0.435654874863642 2751 3523074 SGTC_598 3937-0236 20.2 µM -0.162278409241277 0.433105889217945 no 1955 0.43554330812039 2756 1379313 SGTC_113 0099-0221 2.5 µM -0.162760918194964 0.432922629723768 no 1956 0.43535334031466 2712 89219 SGTC_2626 ethyl orsellinate 100 µM -0.16373283131621 0.432553535727421 no 1957 0.434970735333386 2700 75653 A natural product. SGTC_2052 5265182 7.135 µM -0.165238882752559 0.431981713567875 no 1958 0.434377980939091 2831 1239884 SGTC_3232 9132874 49.47 µM -0.165445066923744 0.431903439999778 no 1959 0.434296842056606 2710 3784940 SGTC_492 tmb-8 126 µM -0.165818421171603 0.43176171056494 no 1960 0.434149924407604 2732 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1797 st048695 56.8 µM -0.167072528147631 0.431285701980312 no 1961 0.433656490768243 2830 592262 YIL048W NEO1 SGTC_1296 1068-0102 11.9 µM -0.167242657273185 0.431221135475513 no 1962 0.433589560698039 2814 767053 SGTC_1404 3909-7820 48.3 µM -0.167642747120137 0.431069302741806 no 1963 0.433432169868787 2745 23741373 SGTC_907 3448-6986 75.5 µM -0.168057630174048 0.430911866795068 no 1964 0.433268970708107 2824 590582 SGTC_1349 flufenamic acid 69 µM -0.16853605411737 0.430730332575443 no 1965 0.433080791114096 2695 3371 A non-steroidal anti-inflammatory. SGTC_1929 genistein trimethyl ether 50.5 µM -0.168642440334984 0.430689967145891 no 1966 0.433038948038147 2729 136420 SGTC_2651 TUB2.036 5 µM -0.169964327436331 0.430188472662034 no 1967 0.432519095497827 2788 15992207 YFL037W TUB2 SGTC_644 1498-1197 63.3 µM -0.169994790255663 0.430176917071957 no 1968 0.432507116896403 2806 6741615 SGTC_2035 5154463 94.595 µM -0.172957340147684 0.429053407685415 no 1969 0.431342479909901 2815 2769623 SGTC_1704 st028805 70.8 µM -0.175455084602284 0.428106615861203 no 1970 0.430361030275009 2774 2876101 SGTC_3215 9129942 49.47 µM -0.178056674078342 0.427120900614841 no 1971 0.42933923365673 2792 17682944 SGTC_92 0063-0024 660.874 µM -0.178897381686326 0.426802462177657 no 1972 0.42900913936663 2659 3594437 SGTC_1545 lovastatin 49.4 µM -0.179885987521192 0.4264280647328 no 1973 0.428621038045627 2765 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2062 5245942 200 µM -0.181323623798234 0.425883732197843 no 1974 0.42805678212691 2693 1376160 SGTC_1913 st060213 96.1 µM -0.182360881230346 0.425491082818931 no 1975 0.427649761629873 2865 688959 SGTC_171 k064-0041 9.68 µM -0.183478932536284 0.425067932011014 no 1976 0.427211123786804 2755 53325 SGTC_2432 5630864 12.22 µM -0.183901501038484 0.424908024230784 no 1977 0.427045363617447 2876 5714970 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.185020219528443 0.424484740069351 no 1978 0.426606588238997 2810 279621 SGTC_1260 0700-1617 7.75 µM -0.18541515111782 0.424335332464279 no 1979 0.426451712792408 2838 2853078 SGTC_1389 3405-0187 19 µM -0.185574974565453 0.4242748723258 no 1980 0.426389040025714 2784 799890 SGTC_2881 9058953 51.95 µM -0.185632602177895 0.424253072623484 no 1981 0.426366442533886 2711 17122249 SGTC_940 3232-1287 54.8 µM -0.186381592467778 0.423969761402329 no 1982 0.426072763296208 2723 1585493 YIL048W NEO1 SGTC_1201 1889-3372 45.9 µM -0.188983159602942 0.422986005183821 no 1983 0.425053007824099 2779 5392199 SGTC_575 k072-0246 11.9 µM -0.189117397971182 0.422935257278008 no 1984 0.425000402962084 2728 6796779 SGTC_3035 9091303 49.47 µM -0.189722622208561 0.422706472246391 no 1985 0.42476324640259 2738 25237002 SGTC_2977 9011197 71.43 µM -0.189833154401992 0.422664692014739 no 1986 0.424719937402631 2972 2704722 SGTC_2153 5569715 200 µM -0.190131675838317 0.422551857792582 no 1987 0.424602974531003 2753 2054701 SGTC_2720 fluspirilene 36.88 µM -0.190561307596197 0.422389478047215 no 1988 0.424434653335734 2839 3396 An atypical antipsychotic. SGTC_2472 5377652 49.4 µM -0.191098681529459 0.422186395609213 no 1989 0.424224140295194 2785 1610903 SGTC_697 0508-1955 564 µM -0.191142615220347 0.422169793259678 no 1990 0.424206930488335 2842 6243113 SGTC_1412 3909-8563 178 µM -0.191388157021582 0.422077006634697 no 1991 0.42411074894876 2830 23767530 SGTC_2360 9040895 200 µM -0.192259797114369 0.421747661661339 no 1992 0.423769354067013 2805 4914414 SGTC_2060 5238662 140 µM -0.192740154192423 0.421566184448796 no 1993 0.423581237261245 2848 790130 SGTC_1904 st060225 78 µM -0.192897861215152 0.421506606921377 no 1994 0.423519480040358 2745 66595 SGTC_2294 7971431 200 µM -0.193444462476162 0.421300129387366 no 1995 0.423305448479151 2877 5741572 SGTC_3218 9131285 49.47 µM -0.193579284938851 0.42124920379652 no 1996 0.423252659794326 2857 17156417 SGTC_1087 pterostilbene 9.05 µM -0.193691327037064 0.4212068838833 no 1997 0.423208791631878 2874 5281727 Similar to reservatol, lowers cholesterol. SGTC_2888 9058547 12.99 µM -0.195652725863985 0.420466183189647 no 1998 0.422440994230153 2770 16476514 SGTC_1732 st034308 51.822 µM -0.195955254372457 0.420351961621522 no 1999 0.422322594389363 2693 830119 SGTC_1125 tnp00248 1.32998 µM -0.196175688206694 0.420268739644553 no 2000 0.422236328159658 2929 24207736 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.197351790512061 0.419824777578837 no 2001 0.421776126609581 2901 551469 SGTC_175 3793-3120 23.7 µM -0.198492970299032 0.419394095781894 no 2002 0.421329692112081 2778 5322297 SGTC_483 fpl-64176 144 µM -0.198698338988914 0.419316599776395 no 2003 0.4212493617065 2762 3423 SGTC_2992 9074591 71.4286 µM -0.199081935866444 0.419171857635842 no 2004 0.421099325743216 2811 17741321 SGTC_684 1140-0066 328 µM -0.200716332030113 0.418555275747911 no 2005 0.420460194242692 2826 6813534 SGTC_2202 7226349 200 µM -0.201297978904722 0.418335895538104 no 2006 0.420232791410951 2743 844334 SGTC_2902 5787006 60.46 µM -0.201307252172341 0.418332398137991 no 2007 0.420229166115072 2771 591003 SGTC_1262 0737-0114 49.6 µM -0.201408901876235 0.418294061515496 no 2008 0.420189427572759 2849 765919 SGTC_568 1193-0097 7.48 µM -0.203498432944667 0.417506178930911 no 2009 0.41937273519347 2828 3646150 SGTC_250 brefeldin a 552.239 µM -0.204157765934898 0.417257638136671 no 2010 0.419115107059108 2751 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_653 0203-0016 55.2 µM -0.204246074772999 0.417224351928739 no 2011 0.419080603846158 2822 295302 SGTC_2101 5377231 179.231 µM -0.204966523684225 0.416952815650074 no 2012 0.418799139978533 2894 2844213 SGTC_889 0919-1524 82.7 µM -0.205650087347506 0.416695217993687 no 2013 0.418532124803297 2831 3905452 SGTC_1707 st032323 6.317 µM -0.206165282448465 0.416501092845801 no 2014 0.418330902932399 2775 3132057 YMR211W DML1 SGTC_1720 st037298 9.481 µM -0.206289169657169 0.41645441526892 no 2015 0.418282518980992 2862 597396 SGTC_2505 galangin 7.89 µM -0.206656323523248 0.416316087870479 no 2016 0.418139134890408 2737 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1977 st070720 65.3 µM -0.206737920530098 0.416285347120811 no 2017 0.418107270401258 2882 682188 SGTC_942 3253-1115 227 µM -0.206866376970538 0.416236953647099 no 2018 0.418057107899846 2937 46497897 SGTC_2669 eugenol 100 µM -0.210015201778918 0.415051093749116 no 2019 0.41682790415628 2824 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1898 st060199 18.6 µM -0.210146495130508 0.415001664877779 no 2020 0.416776668862335 2776 688866 SGTC_2119 5528445 120.635 µM -0.211146072092898 0.414625391736504 no 2021 0.416386645106183 2912 791935 SGTC_2775 cyproheptadine 69.59 µM -0.211641275826588 0.414439010004594 no 2022 0.416193452611149 2831 2913 A selective serotonin reuptake inhibitor. SGTC_1489 4065-0444 182 µM -0.214909566372858 0.413209395946362 no 2023 0.414918913134169 2860 2877968 SGTC_2372 9071633 200 µM -0.215266709879734 0.41307508082511 no 2024 0.414779691425448 2878 21321366 SGTC_2647 atorvastatin 60.16 µM -0.216548704092657 0.412593030235115 no 2025 0.41428003263023 2862 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1300 1094-0077 113 µM -0.217195995055326 0.412349688376812 no 2026 0.414027802837977 2804 5532636 SGTC_1695 st026914 34.495 µM -0.219826955326796 0.411360955752342 no 2027 0.413002962880311 2763 3289191 SGTC_840 0245-0196 390 µM -0.220798142996654 0.41099611873166 no 2028 0.412624804787101 2927 3827528 SGTC_351 caspofungin 25 nM -0.220891076716642 0.41096121121759 no 2029 0.412588622783889 2817 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2663 amphotericin b 100 µM -0.222056430998828 0.410523543917563 no 2030 0.412134977070772 2814 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1452 4194-0072 190 µM -0.222328457078223 0.410421396222135 no 2031 0.412029100428466 2969 1343545 SGTC_313 3474-0040 5.03 µM -0.224025920272738 0.409784124447111 no 2032 0.411368567153613 2796 1043375 YIL048W NEO1 SGTC_2831 7999036 19.48 µM -0.225891759091899 0.409083915001744 no 2033 0.410642803737021 3094 2988270 SGTC_607 4491-0986 66.8 µM -0.226864055864389 0.408719147591663 no 2034 0.41026472630159 2939 698981 YDR232W HEM1 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.227520933111511 0.408472757875601 no 2035 0.41000934687223 2971 23847180 SGTC_2943 9068529 45.32 µM -0.229310158351386 0.407801816679986 no 2036 0.409313929300446 2786 3270634 SGTC_1844 rapamycin 4 nM -0.229637188475314 0.407679212883167 no 2037 0.409186853384918 2780 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_282 k297-0036 65.7 µM -0.229939291553482 0.407565962284852 no 2038 0.409069471989495 2951 5061378 SGTC_2370 9071495 200 µM -0.232691627079693 0.406534540078675 no 2039 0.408000435697779 2897 21791103 SGTC_220 paclitaxel 373.376 µM -0.233125401925306 0.406372044342171 no 2040 0.407832015188764 2924 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3328 9140624 29.0385 µM -0.233281787499066 0.40631346493262 no 2041 0.407771299987949 2990 4904392 SGTC_1518 st038567 90.8 µM -0.233894968881664 0.406083797726478 no 2042 0.407533259572457 2784 77966 SGTC_194 1486-1323 56.904 µM -0.234495575839696 0.405858871599839 no 2043 0.407300133712222 2857 5178754 SGTC_1009 4106-0057 9.87 µM -0.235389023757311 0.405524334623589 no 2044 0.406953402270944 2832 2928005 SGTC_2394 5221648 200 µM -0.236944022626917 0.40494225538398 no 2045 0.406350108562998 2951 788586 SGTC_698 k064-0052 127 µM -0.237320847387756 0.40480123101631 no 2046 0.406203945068666 2797 5088751 SGTC_1525 8-methoxypsoralen 92.5 µM -0.2375359872704 0.404720721771187 no 2047 0.406120502068016 3086 4114 Related to psoralen; DNA damaging agent. SGTC_3084 9116877 49.47 µM -0.23754803634198 0.404716212909363 no 2048 0.406115828905818 2852 27241325 SGTC_2341 7987486 176.74 µM -0.239481295801778 0.403992935560625 no 2049 0.405366199174051 2979 1258686 SGTC_2163 5671233 125 µM -0.239807432279152 0.403870952592352 no 2050 0.405239772474754 3030 701023 SGTC_1209 2323-2347 50.3 µM -0.240134110812732 0.40374877625339 no 2051 0.405113145559656 2821 5412760 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.241100155694609 0.403387534692948 no 2052 0.404738746054666 2812 803109 SGTC_1365 1672-3266 55.4 µM -0.241436896175332 0.403261633753843 no 2053 0.404608259687082 2949 6415873 SGTC_322 k048-0136 19.3 µM -0.242829729788794 0.402740986077877 no 2054 0.404068651853309 2927 6823282 SGTC_221 trifluoperazine 10.304 µM -0.243260413608696 0.402580029324468 no 2055 0.403901834381673 2844 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_3307 9126885 69.2785 µM -0.243894572841615 0.402343059049543 no 2056 0.403656236263924 2841 24824909 SGTC_1684 st024538 14.6195 µM -0.24414882576303 0.402248060831601 no 2057 0.403557779481519 2838 6732859 SGTC_2884 9058502 51.95 µM -0.246733917069894 0.401282504591212 no 2058 0.402557077934687 2947 6471554 SGTC_1600 coumarin 106 71.1 µM -0.248525814388949 0.400613567072564 no 2059 0.40186379973702 2997 100336 A hepatotoxic, DNA x-linker. SGTC_2188 6126565 140.678 µM -0.249770495306323 0.400149083596422 no 2060 0.40138241900989 2958 874518 SGTC_1360 1598-0022 39.8 µM -0.250657271551826 0.399818247203464 no 2061 0.40103954926142 2968 761525 SGTC_2961 9083290 32.55 µM -0.251050438048174 0.399671588565652 no 2062 0.400887556817355 2915 17741490 SGTC_2263 7948595 193.29 µM -0.251119075765897 0.399645986832124 no 2063 0.400861024012308 2845 2971371 SGTC_784 4579-0127 173 µM -0.251139251659542 0.39963846134558 no 2064 0.400853224844426 3048 1948547 SGTC_193 1273-0060 1.558 µM -0.251359451835676 0.399556330433609 no 2065 0.400768107113261 2837 2847393 YHR072W ERG7 SGTC_449 xestospongin c 11.1929 µM -0.251567394359103 0.399478775497372 no 2066 0.400687731866685 2970 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_3102 9121669 49.47 µM -0.251628444624327 0.399456006740147 no 2067 0.400664135134044 2864 41905072 SGTC_269 exalamide 29 µM -0.25412611988925 0.39852479028499 no 2068 0.399699062422019 2873 3316 A derivative of salicylamide. SGTC_2709 st078560 56 µM -0.254474324504806 0.398395013763193 no 2069 0.399564568710521 3012 17250903 SGTC_2780 5215298 71.43 µM -0.255515611009818 0.398006991401592 no 2070 0.399162443922076 3000 2834131 SGTC_988 1497-1057 103 µM -0.256618565932127 0.397596099071643 no 2071 0.39873662065563 2871 3533044 SGTC_1822 st052468 42 µM -0.257653930392179 0.397210490088208 no 2072 0.398337002020937 2902 2873678 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.258486734116817 0.396900395279704 no 2073 0.398015642891406 2920 4213774 SGTC_742 0kpi-0133 140 µM -0.259884087027059 0.396380236871286 no 2074 0.397476593177739 3042 2728852 SGTC_3254 9136651 49.47 µM -0.261444454197294 0.39579961506297 no 2075 0.396874889629437 2883 16454030 SGTC_1358 1509-0022 2.48 µM -0.261818458110429 0.395660480298293 no 2076 0.39673070390635 2935 3258434 SGTC_591 4299-0174 154 µM -0.262475106651887 0.395416229893874 no 2077 0.39647758739215 2916 5509088 SGTC_1612 st002233 45.4 µM -0.265809651677878 0.394176531020402 no 2078 0.395192904792523 2880 1035021 SGTC_1973 st070275 50.2 µM -0.26588526364458 0.394148432792791 no 2079 0.39516378731513 2848 17118334 SGTC_807 1315-0151 48 µM -0.268493582445727 0.393179491448455 no 2080 0.394159707027367 3116 4011080 SGTC_2175 5807670 165.306 µM -0.268752107733136 0.393083490095775 no 2081 0.394060225113192 3011 241186 SGTC_391 gliotoxin 8.33 µM -0.269434823048954 0.392830000349507 no 2082 0.39379754584889 3048 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1677 st019204 53.9 µM -0.269705097798225 0.392729660855989 no 2083 0.393693569182359 2984 3945625 SGTC_471 1-acyl-paf 4 µM -0.270522588295256 0.392426210945305 no 2084 0.393379120787884 2881 16759367 SGTC_2434 5670830 169.91 µM -0.270540044110673 0.392419732113755 no 2085 0.393372407151595 2977 1549830 SGTC_3339 9145883 14.936 µM -0.272580943646157 0.391662445888433 no 2086 0.392587681087818 3026 2030670 SGTC_2693 st077581 40.7 µM -0.272679141658772 0.391626019337119 no 2087 0.392549934923111 3003 25238761 SGTC_1250 0485-0349 40.2 µM -0.273566525556031 0.39129688742079 no 2088 0.392208880832528 2910 6842794 YDL195W SEC31 SGTC_2795 7780010 54.55 µM -0.274358458280466 0.391003224181893 no 2089 0.391904582017304 3032 953673 SGTC_2955 9076254 12.21 µM -0.274674324450852 0.390886112513855 no 2090 0.391783229405987 3011 16459619 SGTC_3213 9129884 49.47 µM -0.276125585498769 0.390348165117244 no 2091 0.391225804964174 3002 17190742 SGTC_1449 4112-4002 201 µM -0.277808488786756 0.389724616377544 no 2092 0.390579687244042 2925 2059539 SGTC_551 k048-0028 34.9 µM -0.278026659569307 0.389643800557213 no 2093 0.390495946927701 3056 6836383 SGTC_801 0866-0028 10.1 µM -0.278176746215706 0.389588207544451 no 2094 0.390438342239468 2862 6849771 SGTC_912 3474-0017 2.18 µM -0.279310770840191 0.389168230979648 no 2095 0.390003170579143 3078 3360550 SGTC_309 k408-0051 1.48 µM -0.283346778054073 0.387674582689772 no 2096 0.388455511075636 2936 3640463 SGTC_2931 9014674 55.67 µM -0.286414740391311 0.386540298797325 no 2097 0.387280243094805 2913 2996810 SGTC_1204 4049-0315 18.3 µM -0.286882804015688 0.38636733172477 no 2098 0.387101028859528 3161 588402 SGTC_2820 7989630 71.43 µM -0.286909467682213 0.386357479178866 no 2099 0.387090820483069 2976 2984098 SGTC_614 0462-0418 107 µM -0.288350780281866 0.38582500600112 no 2100 0.386539119971131 2952 5188303 SGTC_66 0109-0187 42.4 µM -0.292213327485534 0.384399103835457 no 2101 0.385061761132121 2828 759417 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.292927779329205 0.384135526708059 no 2102 0.384788677449096 3151 6728940 SGTC_1722 st034304 3.6505 µM -0.295360469846368 0.383238455696989 no 2103 0.383859263717647 2936 4036148 YLR033W RSC58 SGTC_1694 st024011 44.9 µM -0.29654491416341 0.382801910066496 no 2104 0.383406985992038 2998 2787533 SGTC_981 1488-1094 54.9 µM -0.297168918570799 0.382571983229995 no 2105 0.38316877498405 2877 3449522 SGTC_975 1335-0046 28.5 µM -0.297275222697283 0.382532817483668 no 2106 0.383128198240214 2953 16486740 SGTC_3089 9117425 49.47 µM -0.29776620868985 0.382351938569579 no 2107 0.382940803412624 2988 9401657 SGTC_1420 4'-methoxyflavone 42 µM -0.298925700316859 0.381924884569309 no 2108 0.382498368573698 3017 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1653 st012112 65 µM -0.299296968254096 0.381788172685659 no 2109 0.382356733808062 3102 720429 SGTC_2907 7721985 69.9 µM -0.300332748950202 0.381406845449321 no 2110 0.381961677752159 3004 3267881 SGTC_2671 danthron 100 µM -0.302089192250295 0.380760466335626 no 2111 0.381292035567726 2983 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2968 9090663 33.37 µM -0.302653233376432 0.38055296711939 no 2112 0.38107707073477 3007 25236811 SGTC_1911 st060208 74.3 µM -0.302763584834687 0.380512375087427 no 2113 0.381035018369943 3047 688783 SGTC_2208 7283366 200 µM -0.302869904253262 0.380473267458115 no 2114 0.380994503850212 3029 898663 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.302958198675538 0.380440790918352 no 2115 0.380960859002075 2913 15053 SGTC_298 1391-0729 10 µM -0.306296968384277 0.379213341753461 no 2116 0.379689273623485 2942 3237558 SGTC_1661 st013063 9.66 µM -0.306581613436576 0.379108752336526 no 2117 0.379580925228158 2954 721395 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.306745973651234 0.37904836417287 no 2118 0.379518366824767 3047 616764 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.307315326763939 0.378839198978338 no 2119 0.379301685359994 2990 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3259 9138485 49.47 µM -0.308297539241415 0.378478443659842 no 2120 0.378927969159396 3269 17646153 SGTC_930 2810-3379 265 µM -0.309095676386154 0.378185375050986 no 2121 0.378624374004 3157 1015764 SGTC_2733 amorolfine 100 µM -0.310363786902701 0.37771988072137 no 2122 0.378142164612341 2996 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2224 6650123 117.647 µM -0.310927059034735 0.377513173320934 no 2123 0.377928036597271 2961 2908370 SGTC_2551 apiole 73.87 µM -0.311426370942231 0.377329967121797 no 2124 0.377738254425702 2912 10659 A possible DNA adduct former. SGTC_3241 9133421 49.47 µM -0.311737499757571 0.377215822519504 no 2125 0.377620013198554 3004 17018221 SGTC_2089 5281248 129.67 µM -0.312426657177943 0.376963027831164 no 2126 0.377358147031995 2966 2737878 SGTC_2289 7946404 165.07 µM -0.312695559102304 0.376864404317926 no 2127 0.377255984912269 2928 1246120 YPR165W RHO1 SGTC_2395 5646831 180.19 µM -0.315441654809749 0.375857696617674 no 2128 0.376213171985948 3136 6808628 SGTC_782 0083-0095 30.5 µM -0.317143053901593 0.375234393691831 no 2129 0.375567528728426 2919 3591729 An indicator and reagent. SGTC_2227 7312221 64.1025 µM -0.318292071799343 0.37481363821284 no 2130 0.375131698820848 2979 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_266 formosanin C 406 nM -0.319618171241519 0.374328222963405 no 2131 0.374628898870362 3077 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2256 7954252 200 µM -0.320771713608562 0.373906133706703 no 2132 0.374191698404211 3037 2972920 SGTC_1687 st020778 55.3625 µM -0.321049084571382 0.373804664246474 no 2133 0.374086597009514 2997 4259299 SGTC_2935 9038016 29.96 µM -0.321575455459182 0.373612128235572 no 2134 0.373887170310931 3141 6463195 SGTC_2731 amoxapine 43.43 µM -0.321646315618993 0.373586211404995 no 2135 0.373860326023478 3026 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2730 imipramine 71.33 µM -0.322640356611399 0.373222705051858 no 2136 0.373483813348842 2994 3696 A tricyclic antidepressant. SGTC_3221 9128209 49.47 µM -0.323035278522226 0.373078319138783 no 2137 0.37333426236197 3005 16460723 SGTC_1496 4469-0713 57.4 µM -0.32307557045251 0.373063589159518 no 2138 0.373319005486211 3087 746691 SGTC_1972 st070201 17.4 µM -0.323227482719177 0.373008054532979 no 2139 0.373261484424429 3107 2829099 SGTC_1319 1306-0155 43.7 µM -0.323413654809746 0.372939999127764 no 2140 0.37319099484887 2964 3122360 SGTC_3053 9095903 49.47 µM -0.325595897161235 0.372142574273083 no 2141 0.372365058390885 3050 17174018 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.325705213134752 0.372102642923639 no 2142 0.372323699812717 3083 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2984 9022109 38.96 µM -0.327344426709549 0.37150402999757 no 2143 0.371703696999171 3098 6459207 SGTC_862 0452-0056 10.2 µM -0.328245143391465 0.371175235719795 no 2144 0.371363158738389 3062 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_971 1315-0384 26.7 µM -0.329062824784937 0.370876833732621 no 2145 0.371054101193951 3000 6769120 SGTC_1445 4239-0156 97.7 µM -0.329072654472601 0.370873246990308 no 2146 0.371050386390247 3161 4008346 SGTC_2001 4023502 57.655 µM -0.330427788338774 0.370378881424312 no 2147 0.370538373747808 3095 108941 YCR052W RSC6 SGTC_1327 1436-0082 2.18 µM -0.331563088702902 0.369964877890549 no 2148 0.370109597609023 3015 15992205 SGTC_552 k242-0005 476 µM -0.331760656941011 0.369892847179365 no 2149 0.370034997221604 3116 4088318 SGTC_683 panaxydol 45 µM -0.333343135961749 0.369316061591537 no 2150 0.369437640840256 2999 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1380 2291-0730 164 µM -0.334347278490256 0.368950221818734 no 2151 0.369058759007664 3082 2999191 SGTC_1879 gemcitabine 100 µM -0.33456785281429 0.368869875748889 no 2152 0.368975549198297 3010 60750 A nucleoside analog which inhibits DNA replication. SGTC_443 clozapine 122 µM -0.336583648216808 0.368135871050217 no 2153 0.368215392258587 3060 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2636 apigenin dimethyl ether 100 µM -0.336629364730199 0.368119230021674 no 2154 0.368198158518892 3144 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2645 abamectin 100 µM -0.336645446285077 0.368113376317963 no 2155 0.368192096323254 3115 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_295 k015-0027 31 µM -0.338382159217499 0.367481391378212 no 2156 0.367537608449169 3072 3887424 SGTC_1287 0971-0001 34.6 µM -0.339828955892204 0.366955179966107 no 2157 0.366992670299313 3032 4665869 SGTC_2707 st078556 66.6 µM -0.34153244561171 0.366335927607639 no 2158 0.366351391765837 3065 17250899 SGTC_1043 0916-0009 19.3 µM -0.343019758052101 0.365795544376038 no 2159 0.365791798079956 3186 3101130 SGTC_2970 9090938 41.86 µM -0.344575346774056 0.365230639193562 no 2160 0.365206821184413 3216 17217104 SGTC_660 4031-1742 102 µM -0.344858483087281 0.365127850897704 no 2161 0.365100381866066 3015 6738706 SGTC_2306 7482397 179.52 µM -0.34523129529711 0.364992521922848 no 2162 0.364960246576802 3182 891448 SGTC_261 5-fluorouridine 15.376 µM -0.345877467595303 0.364758004435131 no 2163 0.364717401494197 3227 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.345939303145468 0.364735564901884 no 2164 0.36469416524312 3001 6708630 An antioxidant. SGTC_2478 5763493 32.33 µM -0.346388939891987 0.364572409941317 no 2165 0.364525217967665 3006 1365576 YLR208W SEC13 SGTC_1789 tunicamycin 25 nM -0.346699713403878 0.364459657156893 no 2166 0.364408462775581 3130 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2034 5197015 53.07 µM -0.346941213360864 0.364372045840605 no 2167 0.364317741804623 3170 780676 SGTC_68 0986-0284 82.829 µM -0.347107381174109 0.364311767622144 no 2168 0.364255324239056 3178 423278 YIL048W NEO1 SGTC_247 mechlorethamine 29.705 µM -0.347180513690219 0.364285239493786 no 2169 0.364227854634867 3008 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1051 3253-3903 78 µM -0.347656875353643 0.36411245972166 no 2170 0.364048943550568 2963 5509239 SGTC_2272 7805186 180 µM -0.348848578797611 0.363680341415746 no 2171 0.363601495491482 3154 2956062 YPR165W RHO1 SGTC_3134 9127454 49.47 µM -0.34950451341292 0.363442569799697 no 2172 0.363355291498253 3138 24262820 SGTC_2861 9024595 19.48 µM -0.351853555644055 0.362591490816771 no 2173 0.362474045921023 3054 16482810 SGTC_3148 9097893 49.47 µM -0.35196675685743 0.362550494109485 no 2174 0.362431596725057 3016 17174100 SGTC_545 4218-0007 221 µM -0.352412494473317 0.362389082059466 no 2175 0.362264466522103 3149 2840508 SGTC_2536 dehydroabietamide 32.04 µM -0.353018933282426 0.362169515618909 no 2176 0.36203712324766 3163 3983547 SGTC_950 1165-0508 94.1 µM -0.353321036813005 0.362060153326361 no 2177 0.361923888087529 3097 6148369 SGTC_1264 0783-0040 158 µM -0.353866802714776 0.361862613150293 no 2178 0.36171935346625 2972 2855798 SGTC_2327 6189656 200 µM -0.354183015269329 0.361748176729283 no 2179 0.36160086575253 3127 5349088 SGTC_2798 7813637 45.45 µM -0.355910294561672 0.361123297722631 no 2180 0.360953873007791 3150 956368 SGTC_517 1365-0151 113 µM -0.356468436140883 0.360921457567962 no 2181 0.360744892981408 3199 768657 SGTC_2556 citropten 84.59 µM -0.356968229959675 0.360740750515162 no 2182 0.360557794872825 3053 2775 A potential DNA crosslinker. SGTC_3021 9087658 49.47 µM -0.357408348342332 0.360581645644683 no 2183 0.360393063934675 3148 25237042 SGTC_2168 5727979 200 µM -0.358090693760194 0.360335022278156 no 2184 0.360137721609281 3037 695210 SGTC_3002 9075603 71.4286 µM -0.358320950008149 0.360251812767699 no 2185 0.360051570867804 3069 20105405 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.358633078412411 0.360139027041571 no 2186 0.359934798877374 3223 688751 SGTC_170 4197-0004 226 µM -0.359446908147149 0.359845011818125 no 2187 0.359630394271335 3162 218692 SGTC_610 4215-0184 155 µM -0.362455310632941 0.358758876292323 no 2188 0.35850590664417 3099 5605015 SGTC_157 1348-1695 65.819 µM -0.36417430114978 0.358138774014711 no 2189 0.357863928009035 3073 5380510 SGTC_2082 5219693 150 µM -0.364174514942679 0.358138696915081 no 2190 0.35786384819034 3020 2834649 SGTC_2219 9098279 200 µM -0.364590145204173 0.357988820093644 no 2191 0.357708686103841 3146 902349 SGTC_3200 9114385 49.47 µM -0.365413545033582 0.357691965672373 no 2192 0.357401365912996 3179 17018030 YLR208W SEC13 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.365957014693553 0.357496079597219 no 2193 0.357198575605784 3074 688669 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.367566295831221 0.356916256926409 no 2194 0.356598325040143 3095 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3082 9117008 49.47 µM -0.368368588502028 0.3566273148572 no 2195 0.356299208013028 3079 41448529 SGTC_131 0141-0277 33.849 µM -0.369178855007661 0.35633558453233 no 2196 0.355997207828896 3218 1547771 SGTC_73 0327-0325 16.231 µM -0.37067651884327 0.355796583371522 no 2197 0.355439240801784 3159 53298 SGTC_934 2950-0684 338 µM -0.37191242684732 0.355352003677832 no 2198 0.354979026237877 3243 1121253 SGTC_285 1486-1325 46 µM -0.373148456190076 0.354907577126905 no 2199 0.35451897801107 3175 22310230 SGTC_1291 0993-0025 5.79 µM -0.374997541132223 0.35424308899391 no 2200 0.353831147670206 3171 4353356 SGTC_1793 st048256 72.231 µM -0.375128646294449 0.354195991789452 no 2201 0.353782396701395 3049 672022 SGTC_1825 st052143 62.6 µM -0.377563774998286 0.3533216210713 no 2202 0.352877339715566 3233 674173 SGTC_442 cape 100 µM -0.37804851005591 0.353147661613745 no 2203 0.352697278804858 3204 5281787 SGTC_1993 st073995 70.8 µM -0.379848186930438 0.352502070654274 no 2204 0.352029055210629 3073 3098394 SGTC_3154 9100113 49.47 µM -0.382221633330602 0.351651303147209 no 2205 0.351148488385213 3083 25237525 SGTC_3052 9092717 49.47 µM -0.382740714355251 0.351465336116838 no 2206 0.350956011605636 3224 25237534 SGTC_3155 9099265 49.47 µM -0.383140409707942 0.351322164663427 no 2207 0.350807829440449 3182 25236499 SGTC_2634 4'-methoxyflavone 100 µM -0.384914218743623 0.350687038487865 no 2208 0.350150485503983 3140 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1889 st059080 5.18 µM -0.385768469090662 0.350381316168028 no 2209 0.349834074579581 3248 176925 Isolated from Daphnopsis sellowiana. SGTC_2104 5389443 200 µM -0.386347573122822 0.350174119344906 no 2210 0.349619636034525 3257 2244536 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.386821021352322 0.350004758088955 no 2211 0.349444356801376 3060 91467 include heat shock SGTC_906 1165-0455 526 µM -0.386900436844852 0.34997635260799 no 2212 0.349414958869605 3083 3252859 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.387970224630912 0.349593790805982 no 2213 0.349019034211629 3052 2333 A French combination drug. SGTC_1774 st048371 48.465 µM -0.389257886872629 0.349133518468638 no 2214 0.348542692916651 3058 4242727 SGTC_601 0986-0029 62.9 µM -0.390234028060786 0.348784746500177 no 2215 0.34818175076044 3114 24747981 SGTC_1801 st050089 28.441 µM -0.392815954103723 0.347862849455942 no 2216 0.347227710139674 3102 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1786 berberine 21.6 µM -0.393153784672686 0.347742290759473 no 2217 0.347102950699621 3119 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_625 k213-0058 121 µM -0.394268412479256 0.347344632339519 no 2218 0.346691440819072 3164 3655420 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.39476597937741 0.347167172876557 no 2219 0.346507802243016 3123 688664 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.395193910280147 0.347014576201531 no 2220 0.34634989328967 3126 65057 A dermal irritant. YDR527W RBA50 SGTC_1730 st033808 45.1 µM -0.39568444263179 0.346839686874562 no 2221 0.346168916892481 3085 1045166 SGTC_2941 9056145 11.23 µM -0.396084289762828 0.34669715365246 no 2222 0.346021423770046 3152 2119517 SGTC_1964 st076914 61 µM -0.397151012571414 0.346317005931141 no 2223 0.345628052026142 3132 24208661 SGTC_3325 9138760 55.175 µM -0.39952179955651 0.345472683894657 no 2224 0.344754382171338 3108 43844959 SGTC_2649 anisomycin 9.56 µM -0.400647265105824 0.345072134019532 no 2225 0.344339920849829 3171 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_130 0136-0219 337.655 µM -0.401196770896026 0.3448766295417 no 2226 0.344137628983985 3071 234244 SGTC_2154 5570129 200 µM -0.402526319432645 0.344403770991819 no 2227 0.343648361289715 3187 673366 SGTC_2735 sertaconazole 140 nM -0.402669930343324 0.344352709807021 no 2228 0.34359552879274 3171 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_501 nsc-95397 161 µM -0.404202628190721 0.343807932475339 no 2229 0.34303186062139 3263 262093 SGTC_2553 4-methylesculetin 85.09 µM -0.404459381662224 0.343716704492343 no 2230 0.342937470534736 3174 5319502 SGTC_789 1309-1135 70.6 µM -0.406082495801453 0.343140200867959 no 2231 0.342340993345802 3126 3092424 SGTC_441 propafenone 146 µM -0.406212365593152 0.3430940889887 no 2232 0.342293284542109 3083 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_83 0170-0301 39.027 µM -0.406402790152995 0.343026480613205 no 2233 0.342223334965633 3174 3089716 SGTC_2600 tangeritin 87.95 µM -0.407239813753021 0.342729363195366 no 2234 0.341915931248674 3086 68077 A bioactive flavone. SGTC_1624 st003710 6.25 µM -0.408334988678027 0.34234075696064 no 2235 0.341513877605201 3225 24207033 SGTC_1136 pergolide 1.05886 µM -0.408393725942829 0.342319919643121 no 2236 0.341492319430034 3069 47811 A dopamine receptor agonist. SGTC_974 1326-0144 138 µM -0.408870468817193 0.34215081065829 no 2237 0.341317360954781 3147 5411856 SGTC_1676 st018489 23.4 µM -0.409103110182647 0.342068300211638 no 2238 0.341231996957736 3121 3696235 SGTC_928 2764-0428 58.7 µM -0.410863002366051 0.341444367313983 no 2239 0.340586496362159 3219 662578 SGTC_1254 0550-0035 264 µM -0.412668197327472 0.340804823177547 no 2240 0.339924864186101 3249 15121435 SGTC_89 0302-0250 142.109 µM -0.413434074645465 0.340533626353925 no 2241 0.339644306930565 3194 4203518 YLR208W SEC13 SGTC_1448 4255-0083 152 µM -0.413821071957133 0.340396622114551 no 2242 0.339502575302906 3279 5399660 SGTC_1367 1812-0510 76.9 µM -0.413954882958622 0.340349255432924 no 2243 0.339453574425464 3180 1142582 YDR527W RBA50 SGTC_3000 9075062 71.4286 µM -0.415025472738585 0.339970376698153 no 2244 0.33906162792765 3127 17057871 SGTC_832 4083-0019 164 µM -0.416432424425294 0.339472706149277 no 2245 0.338546803030175 3252 1990758 SGTC_379 3970-0972 5.9 µM -0.4190610503334 0.33854365213789 no 2246 0.337585757696712 3195 2898042 YBL034C STU1 SGTC_951 1171-0579 82.7 µM -0.419169398117006 0.33850537903707 no 2247 0.337546167602029 3160 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2346 9031566 143.75 µM -0.419244287007212 0.338478926032455 no 2248 0.337518804380566 3183 4771086 SGTC_356 1634-0012 32.5 µM -0.420063775053566 0.338189510351429 no 2249 0.33721943251373 3260 735457 SGTC_933 2914-0560 114 µM -0.420351650189318 0.338087865191504 no 2250 0.337114291647647 3286 463887 SGTC_1289 0976-0073 69.1 µM -0.42145873438451 0.337697077438123 no 2251 0.336710069005241 3243 3391136 SGTC_2412 st077135 33.4 µM -0.421718106938128 0.33760554724102 no 2252 0.336615393195616 3357 13258915 SGTC_3029 9088683 49.47 µM -0.422272517740036 0.337409932965296 no 2253 0.336413057664181 3266 25236615 SGTC_427 1354-0053 47.3 µM -0.422333424991886 0.33738844557097 no 2254 0.336390832085632 3323 6813657 SGTC_2754 granisetron 64.02 µM -0.424387474146378 0.336664110990377 no 2255 0.335641627112339 3287 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_3109 9122853 49.47 µM -0.426192702479224 0.336028019748654 no 2256 0.334983717280064 3194 1234709 SGTC_1486 3970-0793 4.53 µM -0.426210221972091 0.336021848867086 no 2257 0.334977334831809 3235 2844330 SGTC_2979 9012552 45.46 µM -0.42685816822527 0.335793654162831 no 2258 0.334741317912846 3252 17100905 SGTC_1629 st005085 44.9 µM -0.426996585359192 0.335744914048224 no 2259 0.334690907396592 3125 24207091 SGTC_1003 4049-0218 100 µM -0.427684706945018 0.335502650351397 no 2260 0.334440342743689 3301 295161 SGTC_785 1270-0111 65.3 µM -0.428718196142217 0.335138923205 no 2261 0.334064158469098 3128 6741994 SGTC_1775 st081588 35.1725 µM -0.431057160738211 0.334316316881701 no 2262 0.333213404309229 3250 1426443 YGL099W LSG1 SGTC_1527 coumarin 137 µM -0.432099228837593 0.333950080641462 no 2263 0.33283464757548 3311 323 A hepatotoxic, DNA x-linker. SGTC_3258 9138477 49.47 µM -0.435971643226478 0.332590503003552 no 2264 0.331428651832781 3205 4970355 SGTC_1745 st081495 74 µM -0.436487499748688 0.332409554986421 no 2265 0.331241533351234 3242 13842402 YBL026W LSM2 SGTC_839 0122-0028 230 µM -0.436917423247679 0.332258779699512 no 2266 0.331085617846505 3169 759448 SGTC_555 4296-0685 37 µM -0.437389268880468 0.332093333456542 no 2267 0.330914532622521 3231 2908540 YHR072W ERG7 SGTC_1644 st010134 20.9 µM -0.43785666023061 0.331929481309749 no 2268 0.330745097271275 3288 3818134 SGTC_1052 3253-3998 198 µM -0.438704115872772 0.331632473010499 no 2269 0.33043797219119 3126 5450317 SGTC_3050 9093513 49.47 µM -0.438737791052504 0.331620673034385 no 2270 0.330425770378904 3204 25236664 SGTC_732 3970-1727 52.7 µM -0.439123979197865 0.331485362441461 no 2271 0.330285852457535 3266 1275699 SGTC_3276 9139060 49.47 µM -0.440616107661208 0.330962764993037 no 2272 0.329745469838232 3220 4870619 SGTC_521 r062-0005 13.8 µM -0.442844176885781 0.330183027406635 no 2273 0.32893922359233 3199 2832033 SGTC_815 1582-0027 36.9 µM -0.443471528823675 0.32996361144107 no 2274 0.328712354151847 3273 3128206 SGTC_278 4092-0821 23.9 µM -0.444218145011651 0.329702559095672 no 2275 0.328442437402144 3256 877900 SGTC_612 0302-0167 22.4 µM -0.444457581442375 0.329618858349603 no 2276 0.328355895271641 3231 235821 SGTC_637 1181-0519 7.26 µM -0.444671867665774 0.329543956697659 no 2277 0.328278451264867 3251 6252091 YGR060W ERG25 SGTC_2635 hydroquinidine 100 µM -0.44571109269045 0.329180802798889 no 2278 0.32790297537935 3173 442912 An experimental heart treatment. SGTC_3320 9137005 35.139 µM -0.445736150959594 0.329172048254044 no 2279 0.327893923878607 3224 4908713 SGTC_793 0488-0545 106 µM -0.446229741280015 0.328999622938932 no 2280 0.327715650728225 3171 292548 SGTC_1817 st052116 64.4 µM -0.447829559756741 0.328441010464898 no 2281 0.327138104159871 3312 4361398 SGTC_2987 9018338 71.43 µM -0.448623760310372 0.328163839824005 no 2282 0.326851545319322 3340 5055682 SGTC_2845 9003024 42.97 µM -0.448775438685998 0.328110915845153 no 2283 0.326796829212147 3386 2990173 SGTC_2492 derrusnin 100 µM -0.449310344566118 0.327924302762895 no 2284 0.326603898232907 3202 1715307 Part of coumarin class of compounds. SGTC_2602 kawain 100 µM -0.45125918577257 0.327244772449226 no 2285 0.325901378579232 3271 5369129 SGTC_2973 9094665 17.96 µM -0.455527653639236 0.32575842613822 no 2286 0.324364838761835 3372 25237061 YIL048W NEO1 SGTC_3201 9113999 49.47 µM -0.457057105210606 0.325226519239361 no 2287 0.323815000304085 3330 16649224 SGTC_1046 2001-0062 216 µM -0.457335710837596 0.325129665114467 no 2288 0.323714882809212 3206 739778 SGTC_3251 9135047 49.47 µM -0.458508184879479 0.324722197188273 no 2289 0.323293691760856 3275 17682963 SGTC_1868 st057644 42.7 µM -0.458684671283323 0.324660881309213 no 2290 0.323230311658754 3180 688665 SGTC_3297 9117502 71.43 µM -0.459979445742995 0.324211189019906 no 2291 0.322765487008499 3298 7453720 SGTC_265 mycophenolic acid 32.932 µM -0.460157553891954 0.324149349745004 no 2292 0.322701567737423 3439 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_3301 9125354 19.7965 µM -0.460620225354503 0.32398873255957 no 2293 0.322535549156891 3263 41905162 SGTC_3045 9092950 49.47 µM -0.460786837231932 0.323930900984563 no 2294 0.322475773134673 3357 44120432 SGTC_920 mycophenolic acid 780.421 nM -0.460971362080984 0.323866856712989 no 2295 0.322409575758253 3207 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1792 st045773 43.6 µM -0.462600459502707 0.323301661396938 no 2296 0.32182538961089 3182 2919270 SGTC_1129 3453-1384 223 µM -0.465316156151658 0.322360390271295 no 2297 0.320852533331997 3378 1084452 SGTC_1321 1326-2144 215 µM -0.465675647580057 0.322235874277792 no 2298 0.320723843053061 3299 3513030 SGTC_1814 st052110 31.539 µM -0.467322188143354 0.321665821908257 no 2299 0.320134692065844 3340 674163 SGTC_2349 9023730 187.07 µM -0.469920773918265 0.32076701391257 no 2300 0.319205810872269 3363 4126287 SGTC_304 1310-0298 97 µM -0.470578826925417 0.320539570571719 no 2301 0.318970765280841 3295 1550234 SGTC_1008 4106-0037 6 µM -0.471162418566984 0.320337919730956 no 2302 0.318762376936631 3201 2905394 SGTC_1636 st007707 68.9 µM -0.47150627980815 0.320219128757923 no 2303 0.318639618114367 3411 403051 SGTC_1936 st074407 74.3 µM -0.471949346862956 0.320066093115533 no 2304 0.318481472057062 3216 809813 SGTC_3130 9127414 49.47 µM -0.472023235364878 0.320040574957277 no 2305 0.318455101894546 3309 1494646 SGTC_1727 st034309 9.9045 µM -0.47308486910191 0.319674022810733 no 2306 0.318076315658069 3410 870305 SGTC_467 ro 31-8220 72.8 µM -0.477609979889782 0.31811360801856 no 2307 0.31646391319513 3237 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2225 6654152 15.4 µM -0.477703062196014 0.318081543756836 no 2308 0.316430782251271 3289 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1418 3966-3099 2.4 µM -0.478127832362912 0.317935239576585 no 2309 0.316279611785495 3336 740335 SGTC_1596 piperlongumine 63 µM -0.478397324390753 0.31784243279189 no 2310 0.316183718810464 3371 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2718 lomofungin 53.02 µM -0.479920846684057 0.317317982470661 no 2311 0.315641838629357 3375 5351222 A RNA synthesis inhibitor. SGTC_563 tetrahydrosecaminediol 614 µM -0.480566015080432 0.317096003087112 no 2312 0.315412487088503 3372 334274 A psychoactive constituent of the cannabis plant. SGTC_820 1582-0060 59.9 µM -0.483058993863237 0.316238877133434 no 2313 0.314526924447099 3250 3848840 SGTC_3147 9097027 49.47 µM -0.484104236243542 0.31587979932067 no 2314 0.314155947500144 3230 25236841 SGTC_1169 aniline yellow 25.8 µM -0.484444399179745 0.315762978732981 no 2315 0.314035257487107 3260 6051 A DNA damaging agent. SGTC_611 3453-1652 23.7 µM -0.484795728338803 0.315642342699009 no 2316 0.31391062656845 3373 1560575 SGTC_156 3474-0145 5.642 µM -0.486418178272876 0.315085496363812 no 2317 0.313335352299095 3357 2265471 SGTC_1638 st008370 60.6 µM -0.487830975662597 0.314600947551742 no 2318 0.312834784421627 3340 24207134 SGTC_1753 st043925 64 µM -0.489138714302974 0.314152715232704 no 2319 0.312371747226236 3339 670181 SGTC_1662 st014054 52 µM -0.490746607665562 0.313601979296138 no 2320 0.311802838727722 3313 2838777 SGTC_1211 1056-0033 32.3 µM -0.491414440331549 0.313373355092945 no 2321 0.311566676481147 3371 6741922 SGTC_1865 st057639 52.2 µM -0.492851410292861 0.312881669488243 no 2322 0.31105879100799 3302 688818 SGTC_1234 0326-0494 15.5 µM -0.495620427198208 0.311935138318273 no 2323 0.310081118962453 3416 1547813 SGTC_2307 7538926 6.34 µM -0.495822685527876 0.311866049035744 no 2324 0.31000975897768 3285 96582 SGTC_2584 androsterone 48.74 µM -0.496309163476381 0.311699900482773 no 2325 0.309838151058952 3373 2754130 A steroid. SGTC_771 0250-0039 27.3 µM -0.49890063191901 0.310815473488808 no 2326 0.308924694427586 3258 3005115 SGTC_1902 st060212 70.5 µM -0.500095000842764 0.310408221616154 no 2327 0.308504093017636 3403 688944 SGTC_1285 0929-0069 65.5 µM -0.500727198756971 0.310192750906848 no 2328 0.308281563819532 3300 1206237 SGTC_587 k089-0003 57 µM -0.500753274070268 0.310183865110133 no 2329 0.308272387005486 3358 9659696 SGTC_1029 k015-0030 64.7 µM -0.501449851031091 0.309946530621173 no 2330 0.308027281599316 3364 2208316 SGTC_2814 7977482 42.97 µM -0.502481717315566 0.309595103430877 no 2331 0.307664354865851 3389 6456762 SGTC_567 1080-0542 68.4 µM -0.502847876042527 0.309470440972326 no 2332 0.307535615179114 3367 5950415 SGTC_2320 7373003 200 µM -0.503882157706751 0.309118427722855 no 2333 0.30717209468188 3349 5415828 SGTC_1564 D-Arginine 115 µM -0.505102444573537 0.308703333689722 no 2334 0.306743442242316 3303 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_880 0833-0487 87.2 µM -0.505133918099341 0.308692630852383 no 2335 0.30673238997029 3319 76075 SGTC_14 0354-0009 295 µM -0.506207798953717 0.308327546042409 no 2336 0.306355390321812 3309 1713507 SGTC_3206 9114350 49.47 µM -0.507766085971651 0.30779811581664 no 2337 0.305808698119168 3343 17087243 SGTC_1685 st024049 53.0905 µM -0.508381406534031 0.30758916985416 no 2338 0.305592944876214 3349 1941139 SGTC_3268 9137683 49.47 µM -0.509220418395947 0.307304365036575 no 2339 0.30529886626834 3265 1953228 SGTC_2064 5220758 200 µM -0.509585477904669 0.307180480870098 no 2340 0.305170949966421 3434 788518 SGTC_516 3992-2719 87.3 µM -0.509913078620366 0.307069327202295 no 2341 0.305056179425728 3204 5350887 YDR037W KRS1 SGTC_3107 9121808 49.47 µM -0.510316251069441 0.306932556668995 no 2342 0.304914959651424 3363 662681 SGTC_2076 5212012 200 µM -0.510502164824066 0.306869497114859 no 2343 0.304849849168302 3317 604802 SGTC_868 0527-0199 213 µM -0.512848549802001 0.306074125156763 no 2344 0.304028632832715 3282 2849450 SGTC_2714 st079313 56.9 µM -0.513332256900294 0.305910272716683 no 2345 0.303859461816536 3325 2939799 SGTC_1325 1431-0015 227 µM -0.514562772630349 0.305493619131544 no 2346 0.303429292431583 3270 1103340 SGTC_913 3487-1245 167 µM -0.515963638506862 0.305019591335897 no 2347 0.302939902719707 3261 4016153 SGTC_3061 glucosamine 200 µM -0.516046905481642 0.304991425578309 no 2348 0.302910824694087 3381 91431 and experimental redox chemotherapeutic SGTC_1992 st073643 23.3 µM -0.516657366715943 0.304784967198938 no 2349 0.302697681015761 3345 3161292 SGTC_268 camptothecin 39.6153 µM -0.51910893396402 0.303956472045742 no 2350 0.301842389301559 3401 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1032 k061-1018 98.7 µM -0.524241496897019 0.30222520832149 no 2351 0.300055290928067 3463 4005393 SGTC_1442 4112-3290 3 µM -0.524279348256022 0.302212457139246 no 2352 0.300042129323375 3346 704353 SGTC_1432 4049-0298 68.4 µM -0.5245743424443 0.302113089202321 no 2353 0.29993956343951 3399 741646 SGTC_296 1222-0039 74.9 µM -0.525845789700713 0.301684973844611 no 2354 0.299497678418897 3344 5984176 SGTC_2983 9022671 12.99 µM -0.527015324456695 0.301291415010693 no 2355 0.299091473335277 3446 6405161 SGTC_2736 butenafine 14.65 µM -0.528396198062709 0.300827036665371 no 2356 0.298612187884798 3318 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2326 6164455 177.58 µM -0.528650347626315 0.300741603098744 no 2357 0.298524013546938 3357 2888790 SGTC_2424 5537928 59.2 µM -0.529485618509931 0.300460900028749 no 2358 0.298234309155201 3342 5382802 SGTC_1375 2910-0797 186 µM -0.529678454390048 0.30039611197453 no 2359 0.298167444375671 3328 742508 SGTC_100 0086-0128 49.5915 µM -0.529964474565776 0.300300027943102 no 2360 0.298068281032148 3364 93297 SGTC_1627 st003713 25.6 µM -0.531143854854441 0.29990398028039 no 2361 0.297659548100168 3383 16195070 YER133W GLC7 SGTC_3295 9122362 53.5725 µM -0.531273691219147 0.299860394384093 no 2362 0.297614566882811 3400 4730473 SGTC_2338 7999974 200 µM -0.531334802643575 0.299839880352115 no 2363 0.297593396181903 3417 315925 SGTC_386 1509-0011 3.07 µM -0.532559869440478 0.299428781049759 no 2364 0.2971691439829 3404 3107280 SGTC_878 0828-0289 13.7 µM -0.533015533424769 0.299275937767093 no 2365 0.297011413818224 3391 745350 YLR208W SEC13 SGTC_657 3534-0529 86.7 µM -0.533754975926932 0.299027982064226 no 2366 0.296755533951852 3418 1049549 SGTC_1681 tripelennamine 100 µM -0.534198372551026 0.298879343557787 no 2367 0.296602147494762 3427 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1185 1319-0113 81.3 µM -0.534484151770529 0.298783560449235 no 2368 0.296503305681629 3412 4672763 SGTC_2617 dihydrotanshinone i 20.83 µM -0.535960402221623 0.298288995720199 no 2369 0.295992958811425 3338 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.536576119134109 0.298082832071677 no 2370 0.295780221753755 3399 521171 SGTC_3096 9117468 49.47 µM -0.53706653296053 0.297918670762018 no 2371 0.295610828582506 3373 41316311 SGTC_84 0443-0269 128.823 µM -0.538686654199384 0.297376643996499 no 2372 0.295051541985127 3404 6150058 SGTC_1160 4092-0570 10.5 µM -0.539250002082904 0.297188276283224 no 2373 0.294857181350316 3388 4994975 SGTC_1920 st075728 45.7 µM -0.539537989579769 0.297092002423453 no 2374 0.294757845594147 3473 3400306 SGTC_3263 9137018 49.47 µM -0.540440451790291 0.296790402843948 no 2375 0.294446658574477 3375 43844957 SGTC_1876 myriocin 605 nM -0.540961043412969 0.296616486791136 no 2376 0.294267217171228 3475 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1107 amlodipine 47 µM -0.541613965312406 0.296398428664838 no 2377 0.294042234610243 3384 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1088 bifonazole 369 nM -0.541873126310724 0.296311896329444 no 2378 0.293952955465972 3394 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.542366217182989 0.296147288179176 no 2379 0.293783123744597 3316 688803 SGTC_2497 7-hydroxyflavone 100 µM -0.543548783966835 0.295752683883119 no 2380 0.293376005936809 3453 5281894 SGTC_2844 9010103 25.97 µM -0.544550439028105 0.295418636134227 no 2381 0.293031374543858 3458 2480525 SGTC_1019 4262-0212 3.4 µM -0.544640378201019 0.295388650292168 no 2382 0.293000439087769 3443 4677213 SGTC_1198 1612-1005 86.7 µM -0.545756338608188 0.295016704115929 no 2383 0.292616719720814 3518 6998509 SGTC_804 1595-0054 20.9 µM -0.545817078826872 0.294996465780182 no 2384 0.292595841094716 3337 761523 Stimulates phospholipase C. SGTC_2313 7726885 200 µM -0.546152782229449 0.294884622631195 no 2385 0.292480460090654 3417 726423 SGTC_787 4152-0075 138 µM -0.547154365971582 0.294551050577189 no 2386 0.292136342256189 3380 9566539 SGTC_284 0988-0104 32.6 µM -0.548735107554175 0.294024947679517 no 2387 0.29159362469002 3421 4666532 SGTC_1963 st076565 50.3 µM -0.549539259619692 0.293757476354767 no 2388 0.291317714886826 3408 4914280 SGTC_407 eburnamonine 100 µM -0.550088610517628 0.293574819930713 no 2389 0.291129299096365 3370 3195 SGTC_1834 st055981 52.8 µM -0.553275673076471 0.292516176601659 no 2390 0.290037328179329 3498 471719 YDL150W RPC53 SGTC_2270 7924575 90.91 µM -0.553424515382304 0.292466779197387 no 2391 0.289986377876763 3464 1262135 SGTC_3136 9095672 49.47 µM -0.554253324448917 0.292191787097669 no 2392 0.289702744498317 3357 17217380 SGTC_3246 9135460 32.98 µM -0.5553643086503 0.291823360414365 no 2393 0.289322750070453 3399 41446951 SGTC_3180 9109287 49.47 µM -0.555647690425857 0.291729419467454 no 2394 0.289225861358008 3458 18891271 SGTC_1950 st077106 7.18 µM -0.556697147095069 0.291381647789978 no 2395 0.288867183230079 3386 13831864 SGTC_584 0986-0246 15.4 µM -0.557898018877202 0.290983937261179 no 2396 0.288457012214257 3504 53315 YDR232W HEM1 SGTC_237 nikkomycin 200 µM -0.558217259694146 0.290878252233573 no 2397 0.288348018193038 3499 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_843 0310-0051 143 µM -0.558343857752033 0.290836346774346 no 2398 0.288304800929072 3415 2065037 SGTC_2228 7354201 200 µM -0.559192895927031 0.29055537802387 no 2399 0.288015040479223 3439 753451 SGTC_2747 doxorubicin 7.63 µM -0.560280789014467 0.290195551738633 no 2400 0.287643964467903 3375 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2927 9011802 47.9 µM -0.560319929267369 0.29018260978851 no 2401 0.287630618095151 3460 43912568 SGTC_475 α-linolenic acid 10 µM -0.560771351351497 0.290033364024864 no 2402 0.287476709553539 3567 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1733 st037357 54.9 µM -0.561370974155635 0.289835176917421 no 2403 0.287272333472842 3384 1272339 YGL099W LSG1 SGTC_3032 9089427 49.47 µM -0.564271293620743 0.288877462330378 no 2404 0.286284757347024 3453 17173707 SGTC_2356 9061756 188.97 µM -0.565008936857859 0.288634122914061 no 2405 0.286033842780028 3418 20104043 SGTC_2007 4011539 71.82 µM -0.567361720631773 0.287858614352796 no 2406 0.285234225760417 3458 45595301 SGTC_1366 1683-0113 21.9 µM -0.567484144085915 0.287818288916625 no 2407 0.285192648098711 3433 708623 SGTC_639 0833-0042 114 µM -0.568271801292215 0.287558903931749 no 2408 0.284925211712052 3402 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_300 r073-0011 5.04 µM -0.570081404411098 0.286963398850796 no 2409 0.284311243471811 3527 2735780 SGTC_363 0455-0021 3.06 µM -0.570158180471063 0.286938146271489 no 2410 0.28428520862116 3477 4597466 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.570193568291101 0.286926507141824 no 2411 0.284273208954188 3496 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1145 3546-0597 10.2 µM -0.571023209561829 0.286653700468435 no 2412 0.283991955036179 3401 875334 SGTC_959 1222-0044 107 µM -0.57323867002864 0.285925805416135 no 2413 0.28324155235577 3478 6083612 SGTC_1928 4'-methoxychalcone 40.3 µM -0.573891401844344 0.285711516449042 no 2414 0.283020645890276 3547 641818 SGTC_2123 5259487 200 µM -0.574604481456643 0.285477502927054 no 2415 0.28277941025978 3467 2173474 SGTC_1781 st038725 66.3 µM -0.575266259673737 0.285260406816846 no 2416 0.282555618361451 3401 4270275 YIL048W NEO1 SGTC_1455 4262-0120 131 µM -0.575551341857614 0.285166909954095 no 2417 0.282459239073455 3561 1529587 SGTC_1748 st037455 53.6035 µM -0.577250285829307 0.284610019571578 no 2418 0.281885195915661 3510 580690 SGTC_2655 perillic acid 100 µM -0.577327031639583 0.284584875617618 no 2419 0.281859278137088 3412 5702197 An apoptosis inducer. SGTC_701 4424-0219 185 µM -0.577750286851762 0.284446225093864 no 2420 0.281716361522422 3534 2911779 SGTC_2425 5628681 7.85 µM -0.578413354025856 0.284229081540462 no 2421 0.281492540111212 3465 5714958 SGTC_2088 5278280 127.392 µM -0.578891989702822 0.284072385525223 no 2422 0.281331027743459 3514 791502 SGTC_423 5-fluorouracil 457 µM -0.579441600779689 0.283892504528024 no 2423 0.281145620399237 3419 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1478 0453-0656 35.7 µM -0.580997683229169 0.283383513628712 no 2424 0.280621007490043 3514 5258496 SGTC_2475 5812728 15.03 µM -0.58232215777924 0.282950626105236 no 2425 0.280174851617641 3493 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_998 3996-0085 177 µM -0.58269175132977 0.282829885876203 no 2426 0.280050413545861 3443 715391 SGTC_3182 9108849 49.47 µM -0.582956693828102 0.282743348682673 no 2427 0.279961226817558 3519 17133045 SGTC_3290 9121031 71.43 µM -0.585474052234935 0.281921748477288 no 2428 0.27911450443845 3426 17014854 SGTC_2447 5741742 33.78 µM -0.58600611197216 0.28174824538994 no 2429 0.278935703786638 3490 1776504 SGTC_2727 riluzole 51.77 µM -0.588148785962892 0.281050047310105 no 2430 0.278216214790626 3500 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2677 mitomycin C 100 µM -0.588275720601724 0.281008711440134 no 2431 0.278173619787963 3491 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2144 5628481 200 µM -0.589012383805209 0.280768877374175 no 2432 0.277926483156723 3464 2818399 SGTC_1547 harmine 94.2 µM -0.589768041185692 0.2805229623034 no 2433 0.277673085729956 3532 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1104 tacrolimus 29.8 µM -0.590931973484965 0.280144385583193 no 2434 0.277283000860709 3527 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1002 4049-0206 172 µM -0.591156256011359 0.280071464659032 no 2435 0.277207864738723 3497 4662749 SGTC_2723 salbutamol 83.58 µM -0.592764621308944 0.279548806949953 no 2436 0.276669343780559 3501 9884233 β2-adrenoceptor agonist SGTC_2817 7995342 71.43 µM -0.594315358344058 0.279045325066248 no 2437 0.276150604117063 3392 18879975 SGTC_406 estrone 100 µM -0.595386374042785 0.278697853223691 no 2438 0.275792615787188 3543 5870 A steroid. SGTC_3323 9138564 53.9225 µM -0.598198072543682 0.277786651733116 no 2439 0.274853888691297 3543 43912313 YNL103W MET4 SGTC_78 0336-0123 156.75 µM -0.598382688612522 0.277726873191864 no 2440 0.274792307028694 3361 6765896 SGTC_1465 k213-0056 144 µM -0.599817377630469 0.277262536228379 no 2441 0.274313975350428 3438 24048857 YMR208W ERG12 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.599982359134259 0.277209164333409 no 2442 0.274258996151664 3518 676296 Flavone; oxidizing agent. SGTC_570 0987-0065 62.6 µM -0.601443268927197 0.276736776081599 no 2443 0.273772393376278 3417 3104428 SGTC_489 paxilline 115 µM -0.602103998935695 0.276523257244256 no 2444 0.273552456407621 3508 105008 A toxic potassium channel blocker. SGTC_464 bw-b 70c 158 µM -0.602975868264706 0.276241631142674 no 2445 0.273262371454622 3548 5353454 SGTC_2097 5376186 200 µM -0.603249918502432 0.276153138129164 no 2446 0.273171222017786 3509 742755 SGTC_733 4069-0007 56.1 µM -0.604693861117279 0.275687107446493 no 2447 0.272691213922939 3556 5717425 YNL287W SEC21 SGTC_685 1278-0033 54.9 µM -0.605084466594021 0.275561106484328 no 2448 0.272561437382439 3568 3590572 SGTC_2378 9074213 121.43 µM -0.605947362902891 0.275282855039819 no 2449 0.272274853516945 3530 657714 SGTC_1246 0422-0085 105 µM -0.606636341153902 0.275060784934134 no 2450 0.272046138616007 3549 264295 SGTC_1983 st071813 46.9 µM -0.60687252131896 0.27498468012451 no 2451 0.271967757665433 3495 11838595 SGTC_2146 5545642 200 µM -0.607184220739518 0.274884256476318 no 2452 0.271864331387291 3541 825326 SGTC_2181 6316240 54.2555 µM -0.607851856559546 0.274669217700086 no 2453 0.271642866242619 3513 12779990 SGTC_24 0417-1663 219 µM -0.610626424771736 0.273776447003686 no 2454 0.270723462352331 3534 4329390 SGTC_2197 6588183 93.1375 µM -0.611862879977798 0.273379056548935 no 2455 0.270314241384305 3516 884136 SGTC_2705 st078069 42.8 µM -0.613173822001303 0.272958038600008 no 2456 0.269880706043788 3485 1530061 SGTC_1236 0330-0013 258 µM -0.616349043688538 0.271939628794205 no 2457 0.268832088314623 3487 4617066 SGTC_271 rotenone 740 µM -0.616414908985292 0.271918523409109 no 2458 0.268810357966936 3579 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.616553587212382 0.271874089054986 no 2459 0.268764607985371 3533 756377 SGTC_1382 3002-2117 298 µM -0.616920720878114 0.271756471974167 no 2460 0.268643509384344 3600 1497314 SGTC_37 0566-0070 1.56 µM -0.617450826780164 0.271586688851835 no 2461 0.26846870297634 3542 1626686 SGTC_2726 cimetidine 79.27 µM -0.618130508877134 0.27136907654635 no 2462 0.268244656394548 3522 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.618556064143256 0.271232871707158 no 2463 0.268104426654658 3673 16725076 SGTC_1886 st057356 49.9 µM -0.620044965964312 0.270756596486834 no 2464 0.267614091601087 3484 24207747 SGTC_2055 5235184 200 µM -0.623283565105933 0.269722065783937 no 2465 0.266549097945704 3560 2836034 SGTC_1141 3253-0389 52.6 µM -0.623725779943008 0.26958095945857 no 2466 0.266403844772178 3538 5402031 SGTC_2132 5317594 122.667 µM -0.624326199828603 0.269389430710103 no 2467 0.266206690513877 3540 794577 SGTC_276 colchicine 750 µM -0.624579993361572 0.269308493287048 no 2468 0.26612337692194 3600 2833 A microtubule depolymerizer. SGTC_2297 7971671 152.32 µM -0.624601735349836 0.269301560105792 no 2469 0.266116240225921 3585 909016 SGTC_745 0469-0705 296 µM -0.625371953432084 0.269056007328269 no 2470 0.265863482639655 3652 3486736 SGTC_469 w7 172 µM -0.62547411139354 0.269023446850514 no 2471 0.265829967249569 3568 45115570 A P450 inhibitor. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.626566613657018 0.268675360843108 no 2472 0.265471679408669 3636 688664 SGTC_3178 9107506 49.47 µM -0.627693134312043 0.268316673248384 no 2473 0.265102491928788 3590 8897194 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.630907953251127 0.267294391410223 no 2474 0.264050355639943 3600 165521 SGTC_3197 9113331 49.47 µM -0.631555555730527 0.267088698057272 no 2475 0.263838668010356 3614 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_182 3448-4371 550.524 µM -0.632370375015748 0.266830006410177 no 2476 0.263572443704615 3590 3491403 SGTC_3059 1327-0034 3 µM -0.63361957099323 0.266433653332432 no 2477 0.263164562684206 3526 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2396 5342950 42.78 µM -0.634057881930707 0.266294653790235 no 2478 0.263021524122261 3551 1886677 SGTC_2212 7123476 200 µM -0.634156985726693 0.26626323054492 no 2479 0.262989188059779 3528 1085715 SGTC_3144 9087057 49.47 µM -0.636214432583792 0.26561129169296 no 2480 0.262318333727865 3537 17249618 SGTC_712 r015-0009 80.6 µM -0.637287141895477 0.265271705915814 no 2481 0.261968912395563 3561 6813872 YLR060W FRS1 SGTC_1961 st076550 68.7 µM -0.637440543019347 0.265223162000678 no 2482 0.261918963452364 3558 1579337 SGTC_1502 4534-4282 27.7 µM -0.641600410239591 0.263908490398016 no 2483 0.260566333275464 3558 3278949 SGTC_33 0986-0033 35.816 µM -0.643332234052199 0.263362151152638 no 2484 0.260004272342876 3542 2848082 SGTC_3160 9100216 49.47 µM -0.643567555678057 0.263287958723017 no 2485 0.259927947324381 3545 17191039 SGTC_2978 9011784 42.97 µM -0.644776311500697 0.262907029323284 no 2486 0.259536077558381 3635 2994934 SGTC_678 1218-2179 85.9 µM -0.646303836694189 0.262426045765756 no 2487 0.259041301822713 3567 6820081 YOR116C RPO31 SGTC_2833 9001315 45.46 µM -0.646581101254069 0.26233878968655 no 2488 0.258951546289912 3537 2989378 SGTC_2782 7736369 71.43 µM -0.647126764841798 0.262167110946415 no 2489 0.258774952150776 3621 2950836 YOL077C BRX1 SGTC_1583 clindamycin 39.6 µM -0.648235059855493 0.261818592274624 no 2490 0.258416464488467 3523 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_675 1309-0189 238 µM -0.64833849889003 0.261786076571064 no 2491 0.258383019364898 3547 4246530 SGTC_3352 9151559 45.5865 µM -0.649098694500571 0.261547175274531 no 2492 0.258137292816334 3544 17159339 SGTC_1892 st058411 7.36 µM -0.64936469440309 0.261463607806737 no 2493 0.258051339311305 3568 3934738 SGTC_1241 0364-0022 50.8 µM -0.650931812126578 0.260971555041061 no 2494 0.257545252408957 3579 4563895 SGTC_350 k064-0020 19.8 µM -0.65444051787974 0.259871600250773 no 2495 0.256414018722009 3610 2790705 SGTC_849 0386-0493 241 µM -0.655337854900079 0.259590675889022 no 2496 0.256125126687488 3553 726119 SGTC_3120 9124077 49.47 µM -0.655578416957682 0.259515391109585 no 2497 0.256047708102068 3646 18774327 YGL155W CDC43 SGTC_790 1575-0012 79.1 µM -0.655649776761628 0.259493060965455 no 2498 0.256024745169565 3634 378741 YLR208W SEC13 SGTC_57 miconazole 162.5 nM -0.656474142545126 0.259235169682533 no 2499 0.255759549707542 3547 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_963 1269-2853 151 µM -0.656559816528959 0.259208375378059 no 2500 0.25573199692855 3583 3668223 SGTC_2056 5235370 200 µM -0.657440113293673 0.258933147909388 no 2501 0.255448983016747 3586 5511916 SGTC_2031 5180455 200 µM -0.657443054595083 0.258932228555992 no 2502 0.25544803766775 3582 29949 SGTC_2762 leflunomide 42.06 µM -0.65777560736102 0.258828294465682 no 2503 0.255341165332872 3599 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_811 0416-0114 265 µM -0.657875433549165 0.258797099587742 no 2504 0.255309088796329 3621 6612453 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.659993944254635 0.25813554116666 no 2505 0.254628857744712 3612 7104 SGTC_1724 st037281 8.293 µM -0.66023298191144 0.258060950715093 no 2506 0.254552164956904 3626 574124 YDL195W SEC31 SGTC_1683 st010134 710 nM -0.660615963322043 0.257941466672674 no 2507 0.254429314517827 3631 3818134 SGTC_1999 st074831 12.5 µM -0.660794435723593 0.257885795958138 no 2508 0.254372075845372 3596 17112523 SGTC_2246 7293507 91.5585 µM -0.662009022491194 0.257507096793877 no 2509 0.253982719687553 3626 887656 SGTC_3103 9120822 49.47 µM -0.663150759717779 0.257151375154503 no 2510 0.253617002016667 3688 17141819 SGTC_2141 5621638 7.665 µM -0.663178323636326 0.257142790451886 no 2511 0.253608176249938 3626 2856238 SGTC_1133 3473-0247 50 µM -0.664265961563305 0.256804167760732 no 2512 0.253260051294646 3584 711311 SGTC_1274 0865-0114 173 µM -0.664808064788552 0.256635477302026 no 2513 0.253086631853602 3617 870624 SGTC_770 0389-1121 67.2 µM -0.665580495681284 0.256395213725475 no 2514 0.252839638288707 3684 6753108 SGTC_1991 st073000 8.92 µM -0.665673003559411 0.256366447137698 no 2515 0.252810066353061 3681 4301969 YIL048W NEO1 SGTC_602 3130-1533 38.1 µM -0.665688003531299 0.25636178285012 no 2516 0.252805271492982 3635 720941 SGTC_1153 4055-0057 267 µM -0.666515251420506 0.256104616057493 no 2517 0.252540909286495 3614 882706 SGTC_962 1254-0300 21.5 µM -0.666572185136268 0.256086922006512 no 2518 0.252522720433888 3584 7340576 SGTC_2524 avocatin b 10.57 µM -0.667400770553441 0.255829483635028 no 2519 0.252258086920559 3566 6710748 SGTC_2173 5763948 167 µM -0.668271347883401 0.255559144128584 no 2520 0.251980199647871 3630 2867177 SGTC_1017 4239-0030 168 µM -0.67136481361468 0.254599741864088 no 2521 0.250994077278702 3608 1149593 SGTC_3211 9128781 49.47 µM -0.672498569293834 0.254248593790538 no 2522 0.250633175316349 3612 17194361 SGTC_989 1501-0895 10.3 µM -0.672931661382331 0.254114523084966 no 2523 0.250495384180512 3625 2830112 SGTC_1608 st001473 40.5 µM -0.674490759476595 0.253632186095901 no 2524 0.249999679274407 3594 7292267 SGTC_199 4063-0024 41.6 µM -0.676445571171462 0.253028107611091 no 2525 0.249378896074153 3655 306215 SGTC_314 1671-0008 2.74 µM -0.67741355827223 0.252729259431772 no 2526 0.249071799156827 3581 3913060 SGTC_2156 5649887 115 µM -0.677742813372001 0.252627650366353 no 2527 0.248967387826775 3686 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2681 menadione 3.18 µM -0.678280509181686 0.252461762176475 no 2528 0.24879692716547 3655 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1861 st057647 17.4 µM -0.679965983820401 0.251942137161155 no 2529 0.24826299985933 3672 688668 SGTC_1715 st032160 10.2275 µM -0.680225787888854 0.251862090854731 no 2530 0.248180753097225 3579 5289825 SGTC_2712 st079126 47.7 µM -0.680311983936264 0.25183553659544 no 2531 0.248153469030075 3618 3152970 SGTC_411 enrofloxacin 100 µM -0.680818082981851 0.251679653404361 no 2532 0.247993303239303 3701 71188 A bacterial gyrase inhibitor. SGTC_767 0929-0023 86 µM -0.681832479942403 0.251367363250864 no 2533 0.247672441933176 3710 1204563 SGTC_1165 k072-0275 30.3 µM -0.685555804595552 0.250222866215709 no 2534 0.246496629534047 3667 6153523 YGL055W OLE1 SGTC_1521 st012942 49.4 µM -0.686282936193874 0.249999679274407 no 2535 0.24626735359767 3689 24207259 SGTC_1214 0358-0031 63.7 µM -0.686630461850068 0.24989304651124 no 2536 0.246157813731526 3698 4301366 SGTC_1082 camptothecin 424.86 nM -0.689185510817699 0.249109811844606 no 2537 0.245353266806804 3606 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_312 4092-0653 6.84 µM -0.690197649197799 0.248799908496036 no 2538 0.245034950747499 3661 1148278 SGTC_1957 st077035 62.4 µM -0.69124129378232 0.248480573435838 no 2539 0.244706958811368 3719 705593 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.691486686456561 0.248405519750401 no 2540 0.244629872242482 3687 23665772 A membrane-active detergent. SGTC_716 1683-5115 658 µM -0.692372867875319 0.248134580585926 no 2541 0.244351600053235 3683 723597 SGTC_1855 st056195 39.6 µM -0.696021705774261 0.24702065556196 no 2542 0.243207618262187 3623 4028379 SGTC_1417 3966-0327 90.4 µM -0.696311654704561 0.246932254224795 no 2543 0.24311683796718 3710 651118 SGTC_2290 7904846 200 µM -0.696689385235301 0.246817114915846 no 2544 0.242998601564089 3719 2962154 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.696709330754932 0.246811035948514 no 2545 0.242992359124865 3699 5282362 SGTC_2658 polymyxin b sulfate 77.05 µM -0.696877762210828 0.246759704843432 no 2546 0.242939647831914 3657 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2022 5136654 200 µM -0.698075382345569 0.246394883468156 no 2547 0.242565026289098 3665 1713771 SGTC_1128 3448-9350 235 µM -0.69834252094823 0.246313546636667 no 2548 0.242481506697856 3690 619386 SGTC_648 0375-0473 33.3 µM -0.699421436325871 0.245985191170821 no 2549 0.242144347583793 3688 1713139 SGTC_3015 9080845 49.47 µM -0.700346220261792 0.245703930871038 no 2550 0.241855556685909 3720 5296973 SGTC_1193 1488-0126 41.5 µM -0.70120313160078 0.245443467303773 no 2551 0.241588127893 3699 1384710 SGTC_2344 7990960 76.95 µM -0.704625854028762 0.244404590867247 no 2552 0.240521552345014 3668 140813 SGTC_1556 plumbagin 1.48 µM -0.705131293228681 0.24425137926961 no 2553 0.240364266894008 3607 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_719 2810-4230 27.3 µM -0.709998448844356 0.242778672868704 no 2554 0.238852549042012 3677 721079 SGTC_317 4495-0002 170 µM -0.710823748285814 0.242529430769169 no 2555 0.238596731166356 3694 15991618 SGTC_3278 9139605 49.47 µM -0.712021039734717 0.242168092827298 no 2556 0.238225873743171 3708 7958859 SGTC_2903 5923464 63.88 µM -0.71225891838475 0.242096336737095 no 2557 0.238152229169675 3734 2876576 SGTC_2241 6772625 37.8075 µM -0.712268732003126 0.242093376706942 no 2558 0.238149191250984 3640 2285411 SGTC_2150 5556613 200 µM -0.712599650801537 0.241993574897119 no 2559 0.238046763953992 3700 743190 SGTC_3024 9090631 49.47 µM -0.713233734725592 0.241802403869642 no 2560 0.237850567265032 3639 25236383 SGTC_667 1498-1044 59 µM -0.713377565579924 0.241759051469818 no 2561 0.237806075817626 3709 6739982 SGTC_1154 4088-0362 150 µM -0.71388422805513 0.241606370736478 no 2562 0.237649385401692 3717 6618304 SGTC_2624 nerol 100 µM -0.714037815232582 0.241560098190446 no 2563 0.237601898228657 3645 637566 A natural product oil. SGTC_1072 oxiconazole 14.9 nM -0.714647652807266 0.241376414613054 no 2564 0.237413395715521 3711 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1578 josamycin 24.2 µM -0.714900427452185 0.241300300933558 no 2565 0.237335286436325 3663 5282165 A P450 substrate. SGTC_2643 anethole 100 µM -0.715011709975435 0.241266796477242 no 2566 0.237300903768381 3697 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.715450603120239 0.241134681096159 no 2567 0.237165326783001 3680 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_3039 9090270 49.47 µM -0.716442670794785 0.240836194389408 no 2568 0.236859027406398 3675 17173750 SGTC_721 1187-1332 279 µM -0.717168228784691 0.240618020674491 no 2569 0.236635150264036 3629 25730 SGTC_2939 9044578 71.43 µM -0.717336113391563 0.240567553469623 no 2570 0.236583364618001 3699 2653634 SGTC_3104 9120930 49.47 µM -0.717351019262875 0.24056307294632 no 2571 0.236578767057882 3719 17014836 SGTC_1148 3909-7663 27.7 µM -0.718506068921328 0.240216017299392 no 2572 0.236222653608184 3748 4084526 SGTC_1982 st072467 71.9 µM -0.721270801605089 0.239386412500075 no 2573 0.235371458931679 3694 3163533 SGTC_91 0417-1751 58.384 µM -0.721397025181629 0.239348574369432 no 2574 0.235332638181167 3802 6795624 SGTC_2250 alverine citrate 130 µM -0.72172333280494 0.23925077204353 no 2575 0.235232296870128 3648 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1864 st057645 30.4 µM -0.723805211531053 0.238627296743414 no 2576 0.234592664696317 3739 688666 SGTC_3085 9117376 49.47 µM -0.724132474700665 0.238529369808456 no 2577 0.234492204592772 3791 16480349 SGTC_168 3970-0862 530.542 µM -0.724793508947766 0.23833163568914 no 2578 0.234289359257298 3717 3135186 SGTC_2682 pyrogallin 40.03 µM -0.726762929960966 0.237743058450795 no 2579 0.233685597755729 3750 822798 An ATP competetive kinase inhibitor. SGTC_1277 0873-0036 22 µM -0.727350583372943 0.237567588101139 no 2580 0.233505609242222 3769 5965735 SGTC_3300 9124615 50.48 µM -0.729453947194888 0.236940117110496 no 2581 0.232862014264054 3735 24824903 SGTC_3293 9120939 62.045 µM -0.730213991405161 0.236713606624649 no 2582 0.232629695770519 3713 934087 SGTC_6 0844-0013 19.835 µM -0.730248345592035 0.236703371108677 no 2583 0.232619197961328 3821 1584900 SGTC_1568 digitonin 820 nM -0.730657071161779 0.236581613740423 no 2584 0.232494321512869 3721 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_135 0933-0004 26.348 µM -0.730672666688687 0.2365769685911 no 2585 0.232489557406267 3718 21230617 YGL099W LSG1 SGTC_2812 7970281 58.44 µM -0.7312246590199 0.236412589235466 no 2586 0.232320970287674 3744 2233435 SGTC_2287 7945887 168.79 µM -0.731793026281623 0.236243399260116 no 2587 0.232147453099041 3762 1245853 SGTC_1780 st038448 24.544 µM -0.733964137704252 0.235597723148973 no 2588 0.23148529764073 3779 728868 YDL195W SEC31 SGTC_562 3772-2733 112 µM -0.734524446675902 0.235431248638685 no 2589 0.231314583154969 3751 2876874 YIL048W NEO1 SGTC_420 mitomycin C 81.9 mM -0.735603177613426 0.235110927630665 no 2590 0.230986114106763 3714 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2126 5251174 33.877 µM -0.735724148783392 0.235075021172082 no 2591 0.230949295136585 3741 790722 SGTC_2622 2-methoxyxanthone 59.94 µM -0.736465997404478 0.234854893174949 no 2592 0.230723576628021 3751 71034 A hepatoprotective. SGTC_1249 0481-0015 10.2 µM -0.736678541192493 0.234791846273102 no 2593 0.230658929728875 3694 4227577 SGTC_496 calpeptin 138 µM -0.738223540195888 0.234333834244959 no 2594 0.230189310156252 3707 73364 A calpain inhibitor. SGTC_1976 st070609 63.5 µM -0.739297045784128 0.234015886924933 no 2595 0.229863321402634 3672 682556 SGTC_2479 5617353 43.85 µM -0.740100550036633 0.233778064150855 no 2596 0.229619492496141 3757 2731746 SGTC_1084 voriconazole 435 nM -0.740121535436188 0.233771854646398 no 2597 0.229613126273985 3736 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2449 5812982 45.77 µM -0.740908398409089 0.233539090702453 no 2598 0.229374491469869 3698 776185 SGTC_2032 5185112 25.99 µM -0.741129457524313 0.233473721776004 no 2599 0.229307475087966 3670 5718189 SGTC_535 2293-4129 48.2 µM -0.741230886022594 0.233443731964934 no 2600 0.229276729652506 3742 396118 YIL048W NEO1 SGTC_633 0437-0093 97.7 µM -0.741298559512389 0.233423723834558 no 2601 0.229256217463568 3710 2831118 SGTC_2813 7971799 71.43 µM -0.741585558899051 0.233338881075148 no 2602 0.229169237883403 3796 2234054 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.741833652627508 0.233265553397708 no 2603 0.229094064177964 3716 97141 SGTC_2689 tacrolimus 100 µM -0.741966705045569 0.233226233106786 no 2604 0.229053754293936 3754 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_54 0159-0055 9 µM -0.744009853696241 0.232622894189091 no 2605 0.228435256917268 3762 3319099 SGTC_894 0960-0238 55.9 µM -0.744616685023328 0.232443865014544 no 2606 0.228251739200619 3716 6741907 YDL195W SEC31 SGTC_1183 1254-0324 198 µM -0.745272423418935 0.232250493303883 no 2607 0.228053524223126 3803 5799357 SGTC_1103 duloxetine 36.1 µM -0.74557644668628 0.232160869792057 no 2608 0.227961657679907 3839 60835 A selective serotonin reuptake inhibitor. SGTC_833 3852-0053 558 µM -0.746639579205395 0.231847618625961 no 2609 0.227640575244525 3796 3123681 SGTC_3324 9138759 60.749 µM -0.747394669462059 0.231625274936719 no 2610 0.227412681052397 3783 45595710 SGTC_1378 2093-0007 380 nM -0.74748452708128 0.231598823399313 no 2611 0.227385569636254 3799 3618014 SGTC_1668 st014914 51.6 µM -0.747887576099607 0.231480197901961 no 2612 0.227263985994424 3757 2839556 SGTC_1655 st012546 55.1 µM -0.747889987194367 0.231479488369838 no 2613 0.227263258774579 3706 720985 YLR208W SEC13 SGTC_2474 5321570 43.32 µM -0.752735605644399 0.23005598185655 no 2614 0.225804404656023 3794 2841384 SGTC_103 0844-0104 51.839 µM -0.754584235233793 0.229514200042054 no 2615 0.225249242830632 3761 5375804 SGTC_2985 9022375 71.43 µM -0.755306294428443 0.229302778931052 no 2616 0.225032611406403 3747 4939335 SGTC_1925 st057770 10.1 µM -0.755917302908118 0.229123959125864 no 2617 0.224849389558469 3754 5989122 SGTC_440 fluspirilene 35.1 µM -0.758473781882662 0.228376620232962 no 2618 0.22408370139001 3887 3396 An atypical antipsychotic. SGTC_2093 5331342 194.4 µM -0.759003738917176 0.228221868781657 no 2619 0.223925160087209 3793 33839 SGTC_958 1222-0007 33 µM -0.759455007474693 0.228090141442819 no 2620 0.223790209394014 3832 7312461 SGTC_2952 9073731 13.78 µM -0.759743633716425 0.22800591255744 no 2621 0.223703920709514 3821 16457353 SGTC_1558 st069300 45.6 µM -0.761310647311225 0.227548921389491 no 2622 0.223235771262609 3710 24208000 SGTC_1474 0330-0125 5.35 µM -0.762331674374073 0.227251435058896 no 2623 0.222931037028844 3777 X1474 SGTC_365 0121-0052 13.6 µM -0.762993334566193 0.227058770915002 no 2624 0.22273368550364 3804 3101739 SGTC_2180 6301957 200 µM -0.763698322143421 0.226853591953066 no 2625 0.222523520445522 3725 845462 SGTC_817 1391-0715 46 µM -0.763864945136268 0.226805113429928 no 2626 0.222473864704838 3774 1353946 SGTC_3037 9091026 49.47 µM -0.764704468744988 0.226560945167945 no 2627 0.22222377229312 3778 25236398 YIL048W NEO1 SGTC_682 0kpi-0099 17 µM -0.764717350880238 0.226557199665404 no 2628 0.222219935980821 3801 1714895 YML126C ERG13 SGTC_1078 idebenone 36.1 µM -0.765401095759606 0.226358449861702 no 2629 0.222016370339267 3838 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2292 7671323 168.05 µM -0.765755032792694 0.226255606738661 no 2630 0.221911037461168 3802 937504 SGTC_853 0419-0306 21 µM -0.767628867444194 0.225711568556922 no 2631 0.221353853554332 3786 762713 SGTC_1253 0550-0034 176 µM -0.767922518962178 0.2256263786197 no 2632 0.221266608972561 3786 5969915 SGTC_1699 st031318 29.054 µM -0.768623515273451 0.225423089266352 no 2633 0.221058420795334 3851 5340658 SGTC_596 1155-0152 116 µM -0.76878036898664 0.225377615796102 no 2634 0.221011852323767 3782 280313 SGTC_1740 st038286 13.222 µM -0.770595446365119 0.224851784532565 no 2635 0.220473380564552 3814 716786 SGTC_74 000s-0487 160.283 µM -0.771166119450365 0.22468660331708 no 2636 0.220304236739967 3717 677548 SGTC_882 0843-0131 351 µM -0.771261274948109 0.22465906727265 no 2637 0.220276040502241 3779 5425421 SGTC_2664 lyso-paf C-16 73.48 µM -0.771973061447581 0.224453151615937 no 2638 0.220065191354688 3767 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2405 ticlatone 3.52 µM -0.773756369235438 0.223937721746864 no 2639 0.219537439233576 3694 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2906 7926292 26.41 µM -0.773836821927393 0.223914484352796 no 2640 0.219513647213938 3759 2966319 SGTC_1901 st060216 58.6 µM -0.774247363680367 0.223795927676304 no 2641 0.219392262067431 3789 688792 SGTC_3222 9128301 49.47 µM -0.776055675873753 0.223274146310621 no 2642 0.218858056526782 3827 4911358 SGTC_955 1216-0110 33 µM -0.777226459090527 0.222936691018475 no 2643 0.218512587155052 3754 3619719 SGTC_1628 st004252 77.7 µM -0.779090103231801 0.222400131921774 no 2644 0.217963319793611 3803 692968 SGTC_2850 9015429 58.44 µM -0.780051996628308 0.222123483033621 no 2645 0.217680135026815 3855 6457570 SGTC_2659 sanguinarine 24.21 µM -0.781182169256515 0.221798686689718 no 2646 0.21734767966554 3746 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_3121 9125696 49.47 µM -0.781810360131445 0.221618270488349 no 2647 0.217163015784049 3863 1235365 SGTC_2020 4017018 200 µM -0.781859285425684 0.221604222681969 no 2648 0.217148637440576 3890 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_450 aminopyrene 156 nM -0.783214538540712 0.221215294335977 no 2649 0.216750569400973 3736 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_3225 9130819 49.47 µM -0.784969968129138 0.220712104913081 no 2650 0.21623558841881 3771 4547121 SGTC_279 1273-0055 2.93 µM -0.785061655937477 0.220685840863141 no 2651 0.216208709938636 3827 2847562 SGTC_1499 4480-0877 67.3 µM -0.785074013338121 0.220682301212216 no 2652 0.216205087487738 3739 2861909 SGTC_9 0092-0002 10.449 µM -0.787760244502658 0.21991363000764 no 2653 0.2154184796391 3789 759368 SGTC_2152 5568786 200 µM -0.788063625526855 0.219826913500213 no 2654 0.215329745173479 3787 5399883 SGTC_508 roscovitine 141 µM -0.789052483877682 0.219544400786881 no 2655 0.215040665989008 3861 160355 A CDKinase inhibitor. SGTC_2420 aureobasidin a 50 nM -0.792086194546689 0.218678984731387 no 2656 0.214155209626972 3913 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_369 0957-0393 4.5 µM -0.793529692847496 0.218267893408029 no 2657 0.213734638321239 3835 6997992 SGTC_1269 0831-0796 3.05 µM -0.79413383637186 0.218095972705735 no 2658 0.213558760629748 3834 927758 SGTC_1273 0849-0096 14.1 µM -0.794578439562973 0.217969502157333 no 2659 0.213429382053545 3842 5286025 SGTC_668 1682-0499 62.6 µM -0.797295324259066 0.217197584202013 no 2660 0.212639767622254 3845 682214 SGTC_3115 9123671 49.47 µM -0.798633390501604 0.216817995569817 no 2661 0.212251510180234 3911 3286988 SGTC_1498 4478-3555 97.6 µM -0.800498987258066 0.216289395440584 no 2662 0.211710875043878 3792 3437919 SGTC_244 nsc-207895 1.295 µM -0.801443439908809 0.216022077941578 no 2663 0.211437487718186 3685 42640 SGTC_655 k060-0012 42 µM -0.802980801988348 0.215587353172104 no 2664 0.21099291547016 3829 5994525 SGTC_765 1319-0117 244 µM -0.803604435268675 0.215411151142199 no 2665 0.210812730407377 3791 3487746 YGL099W LSG1 SGTC_1243 0416-0003 5.65 µM -0.803949275838805 0.215313755391805 no 2666 0.210713135100583 3848 2141977 SGTC_495 decylubiquinone 155 µM -0.804729757775962 0.215093412772704 no 2667 0.210487821767323 3863 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1000 4048-0884 8.67 µM -0.805714122320412 0.214815697573461 no 2668 0.210203852344378 3851 13040088 SGTC_830 4076-0286 57.8 µM -0.806668236562359 0.214546715698935 no 2669 0.209928824385991 3897 6866659 SGTC_2319 6033012 152.6 µM -0.8089966808109 0.213891108173896 no 2670 0.209258527741937 3816 847246 SGTC_484 loperamide 105 µM -0.80953791128993 0.213738884065921 no 2671 0.209102902643995 3817 3955 An opioid-receptor agonist. SGTC_2516 gossypol 71.55 µM -0.809995373051033 0.213610269600526 no 2672 0.208971417515314 3895 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_588 3970-1144 52.9 µM -0.812372506393128 0.212942669600624 no 2673 0.208288958648504 3774 1888707 SGTC_1094 duloxetine 25.4 µM -0.813237340549141 0.212700089826322 no 2674 0.208040997197197 3847 60834 A selective serotonin reuptake inhibitor. SGTC_1511 0906-3109 28.5 µM -0.814913109325052 0.212230508212604 no 2675 0.207561024365792 3888 2882180 SGTC_367 0335-0881 7.1 µM -0.81892683787566 0.211108253763569 no 2676 0.206414078381157 3845 23828853 SGTC_2441 5730946 39.09 µM -0.819074425980681 0.211067053948019 no 2677 0.206371975938112 3938 1774275 SGTC_2674 ligustilide 100 µM -0.819368766751695 0.210984901606488 no 2678 0.206288024573804 3908 5319022 A signalling regulator. SGTC_323 4013-0906 34.3 µM -0.820168013339292 0.210761921490055 no 2679 0.206060166974396 3885 2910086 SGTC_2413 inermin 26.06 µM -0.820300314927325 0.210725024288461 no 2680 0.206022463452885 3965 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1880 MG-132 525 µM -0.821374249801234 0.210425657986662 no 2681 0.205716563173809 3787 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2316 5844804 197.44 µM -0.824162610470847 0.209649550958724 no 2682 0.204923584327434 3929 776813 SGTC_413 propylparaben 100 µM -0.824653683843235 0.209513041078511 no 2683 0.204784116964245 3826 7175 A pharmaceutical preservative. SGTC_2793 7325131 81.82 µM -0.825389816496763 0.209308506939099 no 2684 0.20457515727609 3859 4176441 SGTC_1951 sophoraflavanone G 9.2 µM -0.825692948443352 0.209224316030941 no 2685 0.204489146692257 3861 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_3337 9144342 33.5465 µM -0.827066956046436 0.208842953548529 no 2686 0.204099556056705 3883 17682949 SGTC_2703 st077852 53.4 µM -0.831537835589927 0.207604877075311 no 2687 0.202834931695999 3906 6281836 SGTC_2386 9075165 157.42 µM -0.83156505134096 0.207597353791398 no 2688 0.202827247863446 3840 16452277 SGTC_2644 guaiazulene 100 µM -0.833275606913105 0.207124826122827 no 2689 0.202344655118455 3883 3515 A coloring agent. SGTC_260 nsc-65238 3.989 µM -0.83617888117319 0.206324277134606 no 2690 0.201527138681777 3852 3246252 SGTC_1480 1070-0044 41.2 µM -0.837138302092223 0.206060130012914 no 2691 0.201257416479487 3884 3124987 SGTC_394 menadione 8.33 µM -0.837918098849783 0.205845584703606 no 2692 0.201038351579161 3867 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3329 9141233 27.5565 µM -0.838826749510533 0.205595755110638 no 2693 0.200783268828613 3872 4909101 YNL103W MET4 SGTC_608 k048-0125 159 µM -0.840496028710483 0.205137263323156 no 2694 0.200315163653504 3920 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_996 3970-0799 1.8 µM -0.842605236241525 0.20455880857499 no 2695 0.199724630807931 3925 6615648 YGL040C HEM2 SGTC_234 nsc-17383 10.7 µM -0.843494800011282 0.20431513507156 no 2696 0.199475886377155 3882 408974 SGTC_3332 9141069 11.198 µM -0.844650673928602 0.203998770940129 no 2697 0.199152953647774 3833 17332883 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.845722227092354 0.203705746370156 no 2698 0.198853860272972 3850 6708514 SGTC_81 0411-0046 9.971 µM -0.846897438906037 0.203384664239345 no 2699 0.198526145065589 3810 12925265 SGTC_690 glyoxal 20.3 µM -0.847044449652842 0.203344520378978 no 2700 0.198485173132727 3742 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1224 0823-0416 294 µM -0.847787290937872 0.203141746865149 no 2701 0.198278221100113 3982 3598164 SGTC_21 0849-0113 22.993 µM -0.848686369800429 0.202896486685153 no 2702 0.198027916306354 3850 1560156 SGTC_1850 st056238 17 µM -0.850897987483425 0.202293931516453 no 2703 0.197413011452458 3912 5393177 SGTC_2167 5876490 200 µM -0.851607720923901 0.202100791746533 no 2704 0.197215926431576 4065 686534 SGTC_2799 7812892 81.82 µM -0.852062158721035 0.201977183548928 no 2705 0.197089796683175 3928 20205235 SGTC_842 0271-0008 11.1 µM -0.854161897433189 0.201406637303022 no 2706 0.196507645869753 3960 1221709 SGTC_2109 5483026 200 µM -0.854361086310661 0.201352563412139 no 2707 0.196452475080904 3907 759335 SGTC_2904 7225135 42.03 µM -0.854668112612091 0.201269231895207 no 2708 0.196367454166187 3992 4446116 SGTC_1990 st072050 59.8 µM -0.854996886155869 0.201180020780846 no 2709 0.196276435795523 3912 17233948 SGTC_246 cycloheximide 667 µM -0.856462462849718 0.200782632139691 no 2710 0.19587101363471 3773 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_321 4534-3890 65.3 µM -0.856525012865673 0.200765682297859 no 2711 0.195853721751768 3929 699746 SGTC_947 3447-0010 211 µM -0.858616461596713 0.200199434800925 no 2712 0.195276076510117 3893 748350 SGTC_872 0588-0139 234 µM -0.860089035984888 0.199801320314088 no 2713 0.194869982249252 3886 2047100 SGTC_1333 1482-0047 286 µM -0.860661813035979 0.199646597207713 no 2714 0.194712165415877 3898 3811116 SGTC_383 2324-0395 7.37 µM -0.860760991689747 0.199619813602987 no 2715 0.194684846694962 3935 3146421 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.864145862424272 0.198707011979823 no 2716 0.193753883834431 3928 364106 SGTC_231 b-estradiol 524 µM -0.864494347287058 0.198613178814465 no 2717 0.193658192127515 3873 450 A steroid. SGTC_3256 9138902 49.47 µM -0.864986357515457 0.198480745464267 no 2718 0.193523138352655 3970 17228773 SGTC_1034 k072-0165 12.7 µM -0.865631572143582 0.198307155172968 no 2719 0.193346118006082 3969 5835461 SGTC_2552 juarezic acid 87.02 µM -0.866352211777882 0.198113380693346 no 2720 0.193148520990569 3930 1549512 SGTC_1838 st055369 84.5 µM -0.866730930460762 0.198011591983358 no 2721 0.193044727009209 3920 676036 SGTC_1447 4239-0816 81.9 µM -0.867302942735425 0.197857911396431 no 2722 0.192888022373919 3927 1341554 SGTC_3123 9126162 49.47 µM -0.867959703042774 0.197681550735085 no 2723 0.19270819658749 3996 25239884 SGTC_1940 st075990 51.1 µM -0.869498981388174 0.197268578852015 no 2724 0.192287132484276 4038 1084979 SGTC_320 4092-0846 5.34 µM -0.869824341314628 0.197181355132313 no 2725 0.19219820352873 3906 1359356 SGTC_2111 5486399 200 µM -0.872144293130868 0.196560090321726 no 2726 0.191564832579768 3886 689674 SGTC_1487 3970-0795 2.82 µM -0.872647352479799 0.196425531624607 no 2727 0.191427661023014 3975 3765103 SGTC_3208 9114115 49.47 µM -0.872819356661515 0.196379536625741 no 2728 0.191380773645586 3975 650895 SGTC_1267 0828-0272 9.49 µM -0.873521329887321 0.19619189227055 no 2729 0.191189492655135 4017 745334 SGTC_2187 6125751 200 µM -0.874121301370368 0.19603160018982 no 2730 0.191026099099368 3935 874498 SGTC_2174 5790901 200 µM -0.876051674497934 0.195516409024909 no 2731 0.190500971203918 3957 786020 SGTC_1434 4073-0095 163 µM -0.876971770545629 0.195271137138949 no 2732 0.19025098565221 3893 24133745 SGTC_2722 naftopidil 47.16 µM -0.878612708448184 0.194834173262863 no 2733 0.189805651420678 3852 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2694 st077685 81.9 µM -0.881054606450741 0.194185024466702 no 2734 0.189144132448235 3917 2838096 SGTC_3349 9149703 23.001 µM -0.881250477972102 0.194133011545399 no 2735 0.189091131727822 3938 4910494 SGTC_3168 9103419 49.47 µM -0.883593542122147 0.193511478113749 no 2736 0.18845783319181 3919 16649256 SGTC_3110 9122132 49.47 µM -0.88383073211915 0.193448627583336 no 2737 0.188393796937875 4055 918317 SGTC_1359 1582-0056 520 nM -0.884226848056038 0.193343692676529 no 2738 0.188286883987779 4024 3661189 SGTC_2930 9013230 14.89 µM -0.884330521004064 0.193316234455266 no 2739 0.188258908511358 3985 2995857 SGTC_990 3985-0011 41.3 µM -0.885683179659431 0.192958195167064 no 2740 0.187894137351814 3952 5399565 YGL099W LSG1 SGTC_1312 1218-2183 165 µM -0.887927556389379 0.19236501850185 no 2741 0.187289860366748 3955 6744073 SGTC_3077 9117319 49.47 µM -0.891684856624897 0.191374483593157 no 2742 0.186280936303862 3917 17154678 SGTC_52 0329-0193 875 nM -0.891838249872549 0.191334111141213 no 2743 0.186239818261886 4072 3739292 SGTC_512 prima-1 270 µM -0.892641307216854 0.191122835066486 no 2744 0.186024645408557 3973 322968 A re-activator of the apoptotic function of mutant p53. SGTC_119 0121-0043 24.815 µM -0.893349931555043 0.190936522195517 no 2745 0.185834903188742 3980 1092378 SGTC_1386 3228-0095 33.8 µM -0.893909243196162 0.190789545606183 no 2746 0.185685225931179 3990 870181 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.895028916417768 0.190495525190952 no 2747 0.185385815250703 4022 61125 An anti-inflammatory. SGTC_3309 9129340 25.759 µM -0.895192715329607 0.190452535780279 no 2748 0.185342039093705 3993 17158987 SGTC_1350 1495-0454 146 µM -0.895719651171888 0.190314280638995 no 2749 0.185201256138985 4002 1069057 SGTC_2401 5128683 200 µM -0.89652230812217 0.190103801499587 no 2750 0.184986935658105 3961 708373 SGTC_2857 9024691 58.44 µM -0.89776391417011 0.189778499527638 no 2751 0.184655713410218 4050 16478292 SGTC_2073 5212005 126 µM -0.898939815050011 0.189470728206256 no 2752 0.184342359499025 3766 691789 SGTC_1258 0671-0043 57.1 µM -0.899548919151105 0.189311426773724 no 2753 0.184180175670023 3999 4298767 SGTC_3166 9102297 49.47 µM -0.899811012677274 0.189242905784284 no 2754 0.184110416362298 3992 25237072 SGTC_1736 st036774 51 µM -0.90137483042229 0.188834383135818 no 2755 0.183694529596601 4052 1272247 SGTC_999 SEC7.066 22.7 µM -0.902498883165339 0.188541078098445 no 2756 0.183395957222146 3958 740511 YDR170C SEC7 SGTC_2504 purpurogallin 52.29 µM -0.904722728470464 0.187961626573877 no 2757 0.182806148502294 3889 5281571 An antioxidant. SGTC_1906 st060206 94.7 µM -0.906812737173977 0.187418051279053 no 2758 0.182252916553674 3997 5133468 SGTC_528 3492-0019 172 µM -0.907654205963102 0.187199474360714 no 2759 0.182030472839638 3958 2869262 SGTC_777 1315-0167 517 µM -0.908520545341757 0.186974601918126 no 2760 0.181801631975764 4013 4221767 SGTC_1228 0124-0032 52.5 µM -0.908537331756479 0.186970246382983 no 2761 0.18179719967432 4050 X1228 SGTC_3078 9116413 49.47 µM -0.912464566486235 0.185952980998019 no 2762 0.18076210704996 3894 17177322 SGTC_1070 indatraline 8.81 µM -0.912524732517431 0.185937423024968 no 2763 0.18074627801117 3981 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_3145 9085516 49.47 µM -0.913494452426196 0.185686780321728 no 2764 0.180491274968213 4045 25236195 SGTC_1721 st082152 9.2685 µM -0.915416689691122 0.185190561181846 no 2765 0.179986459993887 3932 5296051 SGTC_2883 9059145 45.46 µM -0.915447087920053 0.1851827206012 no 2766 0.179978483985828 3967 16476510 SGTC_2871 9038510 12.99 µM -0.916080189327671 0.185019472337939 no 2767 0.179812418773907 3922 4945164 SGTC_97 0535-0701 19.132 µM -0.916667196604476 0.18486818957933 no 2768 0.179658530274821 3905 2832013 YGL099W LSG1 SGTC_1144 3486-0183 12.5 µM -0.916834667955515 0.18482504317764 no 2769 0.179614641542124 3979 6744069 SGTC_1651 st011928 86.1 µM -0.918421724702115 0.184416473328936 no 2770 0.179199060694741 4015 720198 SGTC_514 4466-0038 2.65 nM -0.919382415178639 0.18416942761561 no 2771 0.178947791908912 3851 5722064 SGTC_2445 5742597 35.57 µM -0.920654449452081 0.1838426356014 no 2772 0.178615432418149 3960 1774255 SGTC_2863 9028737 58.44 µM -0.921865572110612 0.183531827950151 no 2773 0.17829934953134 3973 6460917 SGTC_148 3253-0744 288.01 µM -0.922293535010184 0.183422079159347 no 2774 0.178187742659611 3909 6893655 SGTC_203 k066-0004 30.888 µM -0.922864022932577 0.183275844224874 no 2775 0.178039035699029 4058 6795412 SGTC_405 ebelactone b 50 µM -0.923555415956778 0.183098714790112 no 2776 0.177858917767977 3965 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2673 kobusone 100 µM -0.923893237285055 0.183012206483851 no 2777 0.177770952215259 4054 6710676 An epoxy ketone and protein crosslinker. SGTC_2361 9034121 116 µM -0.923896117875874 0.183011468940178 no 2778 0.177770202254055 3988 6496917 SGTC_918 glabranin 770.725 nM -0.924266551288589 0.1829166389835 no 2779 0.177673776626209 4016 124049 Also referred to as licorice root. SGTC_1647 st011722 22.4 µM -0.924708112122821 0.182803640669083 no 2780 0.17755887930703 3972 2854783 SGTC_283 0987-0079 11.7 µM -0.925351111608307 0.182639170827375 no 2781 0.177391650078533 4013 411556 SGTC_1439 4092-1168 46 µM -0.926166208124904 0.182430813941598 no 2782 0.177179805381262 4011 2886240 SGTC_1229 0139-0193 12.2 µM -0.926227223526503 0.182415223017466 no 2783 0.177163953826209 4064 3090752 SGTC_2684 capsaicin 100 µM -0.927436656784876 0.1821063551022 no 2784 0.176849932819847 4031 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1187 1391-0724 117 µM -0.927634881397245 0.182055763234897 no 2785 0.17679849874134 4059 6997986 SGTC_2511 berberine 10.47 µM -0.931108450323553 0.181170648375094 no 2786 0.175898733933054 3988 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_936 3005-4620 401 µM -0.93216049691227 0.180903104619084 no 2787 0.175626793582542 4041 777207 SGTC_1905 st060207 84.5 µM -0.932625484835662 0.180784933466271 no 2788 0.175506685196163 3959 1948547 SGTC_2170 morpholine 200 µM -0.934088035358496 0.1804135592086 no 2789 0.175129241594281 4041 121171 Reacts with secondary amines. SGTC_619 1652-1634 108 µM -0.936244767586551 0.179866790691164 no 2790 0.174573589237543 3983 5400454 SGTC_2267 7931562 200 µM -0.937374029482557 0.179580919071668 no 2791 0.174283097525878 3930 934880 SGTC_429 1112-0049 25.5 µM -0.939483088247542 0.179047777914733 no 2792 0.173741385572614 3983 2836170 SGTC_2172 5754775 163.918 µM -0.940372807541655 0.178823168041696 no 2793 0.173513182659619 3986 2263357 SGTC_2563 tomatine 8.54 µM -0.943305407645901 0.178084088839105 no 2794 0.172762355340959 3900 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1067 clotrimazole 1.36 µM -0.944072759773605 0.1778910176875 no 2795 0.172566234164749 4040 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1622 st003707 19.4 µM -0.947412889622871 0.177052156481489 no 2796 0.171714212772552 4053 10140899 SGTC_1804 st050076 49.1 µM -0.947690872977783 0.17698245482679 no 2797 0.171643424353113 4063 3895976 SGTC_2706 st078239 82.5 µM -0.948761175337354 0.176714248724207 no 2798 0.171371046128488 3998 15434492 SGTC_1419 3993-2473 62.6 µM -0.950214509215896 0.176350470707519 no 2799 0.171001633852433 4093 704026 SGTC_2917 7979103 53.79 µM -0.951725323513195 0.175972807678365 no 2800 0.170618151492963 4105 2980565 SGTC_3286 9117135 37.221 µM -0.953941476447737 0.175419756252065 no 2801 0.170056633530866 4005 3438150 SGTC_621 3584-0052 32.1 µM -0.953959839602751 0.175415178247762 no 2802 0.170051985718035 4034 2273927 SGTC_1978 st071761 42 µM -0.955118876272035 0.175126379267876 no 2803 0.169758792086138 4062 5147680 SGTC_2887 9044784 58.44 µM -0.95567567948388 0.174987747048784 no 2804 0.169618056709759 4006 6465546 SGTC_2546 rhodinyl acetate 100 µM -0.956110309099575 0.174879581873849 no 2805 0.16950825347731 3974 6708682 SGTC_715 0868-0130 184 µM -0.957445916826526 0.174547458164568 no 2806 0.169171115938131 4087 2876258 SGTC_706 4262-0057 46.9 µM -0.957467639074515 0.174542059836031 no 2807 0.169165636312877 4025 883298 SGTC_3014 9081533 49.47 µM -0.957754808524375 0.174470703568485 no 2808 0.169093206043474 4086 21367265 SGTC_1024 4507-0395 26 µM -0.958032634642734 0.174401686582332 no 2809 0.169023151318632 4120 4201836 SGTC_899 1083-0020 478 µM -0.958796032729425 0.174212134135087 no 2810 0.168830754100122 4105 767123 SGTC_1819 st053448 58.6 µM -0.959059868635123 0.174146653892401 no 2811 0.168764292961193 3956 2857616 SGTC_2481 5478948 45.16 µM -0.959132217711295 0.174128700635046 no 2812 0.168746070926834 4093 77792 SGTC_2221 6807166 181.081 µM -0.960505091342843 0.173788248177112 no 2813 0.168400534904528 3979 674925 SGTC_1477 0139-0234 16 µM -0.960700054672123 0.173739934495824 no 2814 0.168351501867257 4061 620880 SGTC_41 0478-0632 82.643 µM -0.961330919391896 0.17358365905696 no 2815 0.168192903100762 3952 3750424 SGTC_2772 vinpocetine 57.06 µM -0.961792234734878 0.173469440389053 no 2816 0.168076989744504 4068 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_3023 9089636 49.47 µM -0.961899111924279 0.173442985121122 no 2817 0.168050142362014 4106 17249241 SGTC_822 1487-0950 154 µM -0.963360641537478 0.173081470986016 no 2818 0.167683285347092 4066 1958375 SGTC_885 0865-0106 16.8 µM -0.964709889072486 0.172748156597369 no 2819 0.167345070343139 3974 2793380 SGTC_2373 9071805 200 µM -0.964931645352441 0.172693413712816 no 2820 0.167289524934995 4042 10149009 SGTC_1038 k292-0204 154 µM -0.966981126620425 0.172188001078142 no 2821 0.166776734329525 4017 4454212 SGTC_710 3448-4187 58 µM -0.967006098620179 0.172181848680921 no 2822 0.166770492468802 4031 3946412 SGTC_714 4296-0578 26.1 µM -0.967402727672486 0.17208414926587 no 2823 0.166671373508816 4082 1589775 SGTC_1611 st001856 99.4 µM -0.967894942685873 0.171962953909527 no 2824 0.166548420164102 4027 647478 SGTC_786 4544-0069 423 µM -0.971812383427886 0.171000327837003 no 2825 0.165571947054325 4066 748821 YLR208W SEC13 SGTC_482 fipronil 114 µM -0.972095541805399 0.170930881649719 no 2826 0.165501509920526 4129 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_3038 9091290 49.47 µM -0.978249841125697 0.16942596457624 no 2827 0.163975385574688 4092 25236843 SGTC_1065 prochlorperazine maleate 2.48 µM -0.979940920235392 0.169013937035191 no 2828 0.163557641196417 4108 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1948 st076329 66.6 µM -0.981079409012139 0.168736909656074 no 2829 0.163276791847485 3920 24208413 SGTC_3209 9113616 49.47 µM -0.982150456919421 0.168476559143891 no 2830 0.163012865433986 4128 16649353 SGTC_2237 6667747 47.222 µM -0.983822091817397 0.168070734283756 no 2831 0.162601497569161 4068 729940 YDL015C TSC13 SGTC_1334 1486-0610 236 µM -0.985600207439909 0.16763975000645 no 2832 0.162164668102618 4158 3742339 SGTC_2533 agelasine 13.65 µM -0.986075165945629 0.167524748898666 no 2833 0.162048114539323 4134 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2375 9072683 200 µM -0.986319146806631 0.167465693882377 no 2834 0.161988263497756 4119 16798029 SGTC_1719 st032227 49.2 µM -0.98836170048871 0.16697182463985 no 2835 0.161487768794767 4082 3125804 SGTC_2838 9002687 71.43 µM -0.9889669982643 0.166825650245288 no 2836 0.16133964425622 4052 6457060 SGTC_2018 5133068 143 µM -0.989779522813173 0.166629562131856 no 2837 0.161140947888409 4045 785362 SGTC_504 lovastatin 124 µM -0.99177794020135 0.16614791333169 no 2838 0.160652930490476 4097 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_838 0109-0203 71.4 µM -0.996032884245191 0.165125406750795 no 2839 0.159617083868429 4083 759422 SGTC_1015 4130-4525 82 µM -1.00056932165553 0.164039750816112 no 2840 0.158517533972622 4088 1363237 SGTC_898 1000-0849 28.3 µM -1.00064339406177 0.164022062386301 no 2841 0.158499621486783 4086 6751807 SGTC_1045 1348-1485 165 µM -1.00069063958665 0.164010780840092 no 2842 0.158488197078255 4076 6810614 SGTC_65 0798-0905 34.986 µM -1.00142263771279 0.163836054626709 no 2843 0.158311262115323 4209 3602145 SGTC_856 0433-0016 11.3 µM -1.00176507575018 0.163754356972396 no 2844 0.158228534202137 4141 3911780 SGTC_2408 sulbentine 18.36 µM -1.00187562480289 0.163727988218231 no 2845 0.158201833261409 4055 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1921 5740136 50 µM -1.00243774695969 0.163593950463007 no 2846 0.158066109501567 4045 1774243 SGTC_2679 rapamycin 1 nM -1.00347709146295 0.1633463069853 no 2847 0.157815362321001 4025 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_594 1487-1584 10.8 µM -1.00369777517481 0.163293756279028 no 2848 0.157762154887874 4056 5013332 SGTC_1142 3253-1408 9.78 µM -1.00582687868865 0.162787323923065 no 2849 0.157249427607619 4101 256655 SGTC_2431 5490079 200 µM -1.00683760431362 0.162547268859652 no 2850 0.157006410226108 4147 5722345 SGTC_1113 artemisinin 1.17947 µM -1.00695074441571 0.162520411562445 no 2851 0.156979222369648 4146 2240 An anti-malaria and mitochondrial poison. SGTC_3292 9120825 59.784 µM -1.00715305551745 0.162472393973147 no 2852 0.156930614214295 4103 24824900 SGTC_1594 piperine 70.1 µM -1.00821613373427 0.162220229087575 no 2853 0.156675357106454 4072 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1115 galangin 695.678 nM -1.01099722055683 0.161561754084054 no 2854 0.156008880043137 4154 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_800 3448-7362 155 µM -1.0110234537755 0.161555551179883 no 2855 0.156002602259388 4173 15991913 SGTC_233 rapamycin 362 pM -1.01231399762888 0.161250590853278 no 2856 0.155693972100445 4088 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2960 9079389 5.97 µM -1.01423531686197 0.160797272103711 no 2857 0.155235240158474 4103 16457355 SGTC_1503 4585-0012 61.3 µM -1.01462425075252 0.160705607863277 no 2858 0.155142487445094 4158 2922052 SGTC_794 k038-0031 316 µM -1.0146792167757 0.160692656180979 no 2859 0.155129382133274 4089 6624242 SGTC_1363 1636-0063 10.4 µM -1.0153733325894 0.160529159846756 no 2860 0.154963949986186 4111 6072185 SGTC_1131 3454-3128 32.3 µM -1.01960755899621 0.159534158198364 no 2861 0.153957309299659 4152 710982 SGTC_2877 9040724 71.43 µM -1.0199154932579 0.159461954468474 no 2862 0.153884270485109 4109 6463895 SGTC_465 cgp-37157 41 µM -1.02186313746422 0.159005770888102 no 2863 0.153422840745761 4048 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_124 0136-0217 7.121 µM -1.02197892136649 0.158978678559251 no 2864 0.153395438479673 4158 3976905 SGTC_1176 0848-0131 83.3 µM -1.02215137008076 0.1589383328127 no 2865 0.153354631515006 4151 6769040 SGTC_1675 st018485 24.5 µM -1.02575381801234 0.158097045759751 no 2866 0.152503819751243 4160 3323024 SGTC_3017 9080681 49.47 µM -1.02585155292993 0.158074262324721 no 2867 0.152480780835308 4130 16451914 SGTC_3229 9132204 49.47 µM -1.02726543697984 0.157744906455498 no 2868 0.152147746317692 4165 17682924 SGTC_111 0083-0039 52.457 µM -1.02785020215684 0.157608820748549 no 2869 0.152010148606564 3994 759313 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.02884652854758 0.15737713483446 no 2870 0.151775899245307 4157 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1747 st037496 66.6 µM -1.02959524940829 0.157203174558395 no 2871 0.151600023125856 4099 723305 SGTC_2216 7189485 200 µM -1.03003070873273 0.157102056677896 no 2872 0.151497795140091 4121 731273 SGTC_890 0929-0006 47.2 µM -1.0301082248529 0.157084061168715 no 2873 0.151479602341563 4093 1378169 SGTC_1391 3442-0225 151 µM -1.03036206365287 0.157025141515848 no 2874 0.151420037311349 4093 5227075 SGTC_1433 4060-0023 7.6 µM -1.03147721741286 0.156766470447161 no 2875 0.151158543297107 4140 3840627 SGTC_2388 9080168 200 µM -1.0318774474605 0.156673701507515 no 2876 0.15106476608277 4100 15943073 SGTC_1557 sumaresinolic acid 42.3 µM -1.03242015249383 0.156547966158645 no 2877 0.1509376676496 4095 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.03414964370548 0.156147716350625 no 2878 0.150533105576199 4089 688761 SGTC_696 1560-0013 611 µM -1.03449342162066 0.156068237494122 no 2879 0.150452775282676 4189 1650269 SGTC_3275 9138069 49.47 µM -1.03645420891722 0.155615428039542 no 2880 0.149995145821104 4212 17617007 SGTC_150 3970-0969 77.2 µM -1.03852124552015 0.155139021340642 no 2881 0.149513724720521 4214 6615640 SGTC_1010 4112-3296 15.2 µM -1.04129264087234 0.154501787891088 no 2882 0.148869875559152 4208 704384 SGTC_865 0488-0499 301 µM -1.0423746432494 0.154253470808967 no 2883 0.148619008925367 4105 9634651 SGTC_5 0352-0601 109.883 µM -1.04293532780019 0.15412489885967 no 2884 0.148489123176673 4062 762456 SGTC_695 3505-6186 243 µM -1.04427065800504 0.15381897655623 no 2885 0.148180092127466 4152 1819379 SGTC_209 4077-0173 175.592 µM -1.04431465195662 0.15380890444638 no 2886 0.148169918080602 4116 15993494 SGTC_549 1661-1316 519 µM -1.04526027146125 0.153592516959257 no 2887 0.147951346989075 4172 2857282 SGTC_332 4112-0506 40.9 µM -1.04534571210933 0.153572975386174 no 2888 0.14793160882045 4085 2790355 SGTC_2286 7945697 125 µM -1.04558402903255 0.153518477389642 no 2889 0.147876563080929 4172 1245733 SGTC_2928 9011484 9.79 µM -1.04581614354526 0.153465410065986 no 2890 0.147822963139738 4162 2994751 SGTC_1848 st056003 16.4 µM -1.0463366598976 0.153346450871975 no 2891 0.147702812672265 4160 146492 SGTC_2176 5809774 33.9695 µM -1.04654232725895 0.153299464342496 no 2892 0.147655356633964 4085 2870539 SGTC_2849 9019321 12.99 µM -1.0473894117689 0.153106040947644 no 2893 0.147460006566081 4162 16489627 SGTC_1852 st056254 31.4 µM -1.04807862633688 0.152948784994666 no 2894 0.147301191435765 4070 442583 SGTC_174 3553-0389 74.3 µM -1.04818577643747 0.152924346509984 no 2895 0.147276511229126 4226 738071 SGTC_626 0214-0009 33 µM -1.04994517459719 0.152523438360635 no 2896 0.146871660119626 4203 3437874 SGTC_1482 3346-2049 8.48 µM -1.05101254494975 0.152280560453673 no 2897 0.146626414106382 4146 3826804 SGTC_2203 7227154 166.4 µM -1.05146806054818 0.152176987035543 no 2898 0.146521835569171 4138 896304 SGTC_3250 9135583 49.47 µM -1.05321570273249 0.15178004882645 no 2899 0.14612107162032 4191 7699353 SGTC_2848 9016370 25.97 µM -1.053600723919 0.15169269235965 no 2900 0.146032878814044 4142 7894410 SGTC_2911 7942208 15.64 µM -1.05522889170123 0.151323651048597 no 2901 0.145660326753736 4174 1243384 SGTC_768 0384-0033 77.3 µM -1.0559317349002 0.151164528934203 no 2902 0.145499702085274 4122 3965305 YMR134W ERG29 SGTC_2117 5521686 200 µM -1.05867616672377 0.150544262064791 no 2903 0.144873642827147 4095 803312 SGTC_901 1112-0062 60.1 µM -1.0598241909642 0.150285301612432 no 2904 0.144612294607025 4179 1908457 SGTC_58 0957-0393 9 µM -1.06131759938565 0.149948877168847 no 2905 0.144272795103628 3923 6997992 SGTC_1981 st071826 47 µM -1.06135920585589 0.149939511554968 no 2906 0.144263344321018 4176 11838600 SGTC_3273 9137859 49.47 µM -1.06648197169594 0.148789357766052 no 2907 0.143102912033014 4226 2377234 SGTC_2853 9015042 58.44 µM -1.0665556673634 0.148772854890693 no 2908 0.14308626429617 4077 6457456 SGTC_1490 4089-0339 670 nM -1.07060062391089 0.147868932716413 no 2909 0.142174521412982 4131 742542 SGTC_1226 3909-7979 35.4 µM -1.07265895064705 0.147410375124248 no 2910 0.141712082272466 4153 6615510 SGTC_774 k060-0086 136 µM -1.07712989867969 0.146417615517391 no 2911 0.140711118750462 4189 5911235 SGTC_2222 6885208 172.143 µM -1.07780235178502 0.146268688704454 no 2912 0.140560984901668 4131 609514 SGTC_2334 9017922 200 µM -1.07800390178864 0.146224071658317 no 2913 0.140516007445094 4230 3163164 SGTC_191 3914-0123 66.505 µM -1.08216195888453 0.145305643497649 no 2914 0.139590284292657 4180 3144412 SGTC_152 4469-0003 551.229 µM -1.08236606966184 0.145260659830082 no 2915 0.13954494941596 4107 697280 SGTC_2945 9067681 61.76 µM -1.08358830394856 0.144991489505291 no 2916 0.139273689481389 4250 16456930 SGTC_1307 1187-1599 12.2 µM -1.08420523179452 0.14485575225328 no 2917 0.13913690624706 4160 1538471 SGTC_63 0099-0242 26.702 µM -1.08435869246551 0.144822000934079 no 2918 0.139102895651866 4202 3898502 YLR359W ADE13 SGTC_2259 7964009 200 µM -1.08933126207359 0.14373122607029 no 2919 0.138003915756746 4220 313134 SGTC_2204 7233102 200 µM -1.09234910644564 0.143071946576158 no 2920 0.137339841844779 4091 2172480 SGTC_2331 7980721 200 µM -1.09302429219241 0.142924725354805 no 2921 0.13719156706204 4145 2981221 SGTC_769 0302-0231 76 µM -1.09374076105011 0.14276861453182 no 2922 0.137034345886078 4106 571869 YER009W NTF2 SGTC_2608 thymoquinone 42.66 µM -1.09870657081172 0.141689786826862 no 2923 0.135948037779112 4185 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_104 0074-0074 590.992 µM -1.10204560442775 0.140967490717675 no 2924 0.135220922883907 3961 3943124 SGTC_3179 9107801 49.47 µM -1.10445175759219 0.140448545227596 no 2925 0.134698609767984 4189 4818259 SGTC_1514 1189-1591 158 µM -1.1063289070439 0.140044594013969 no 2926 0.134292092152715 4221 767698 YMR146C TIF34 SGTC_1102 cgs 12066b 26.1 µM -1.10707369125541 0.139884539909075 no 2927 0.134131034544389 4201 6438352 A 5-HT1B full agonist. SGTC_571 k831-0106 44.2 µM -1.1091672163173 0.139435307533335 no 2928 0.133679026220637 4063 4783639 SGTC_2860 9025725 38.96 µM -1.10961794311164 0.139338718295606 no 2929 0.133581847972754 4238 40546248 SGTC_87 0100-0052 35.5 µM -1.11202916891488 0.138822773952185 no 2930 0.133062804539343 4239 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1430 4049-0248 69.1 µM -1.11574704648254 0.138029790006241 no 2931 0.132265213100189 4218 22774488 SGTC_341 1486-1430 230 µM -1.11702178033542 0.137758615354636 no 2932 0.131992506335145 4164 2054753 YPL210C SRP72 SGTC_2870 9038528 12.99 µM -1.12096208193098 0.13692269305696 no 2933 0.131152001500114 4255 6463316 SGTC_896 0964-0007 44.5 µM -1.12136559850389 0.136837284412739 no 2934 0.131066136624227 4177 6756758 SGTC_1166 k206-0078 225 µM -1.12479472861985 0.136112941649045 no 2935 0.130338014370225 4227 5404595 SGTC_778 3456-2434 196 µM -1.12561237623754 0.135940616322546 no 2936 0.130164813604774 4176 5539063 SGTC_1155 4088-0394 48.2 µM -1.12637838941137 0.135779308918252 no 2937 0.130002695025213 4182 2326248 SGTC_2990 9074105 71.4286 µM -1.12784065093135 0.135471749306244 no 2938 0.129693611033376 4132 6502001 SGTC_2138 5575593 77.673 µM -1.12895094460135 0.135238538707438 no 2939 0.129459264069329 4217 762213 SGTC_2713 st079149 53.4 µM -1.12951063218344 0.135121084049747 no 2940 0.129341243476753 4224 3103253 SGTC_1816 st051957 91.6 µM -1.13043830037195 0.134926559978228 no 2941 0.129145791551439 4210 674121 SGTC_2450 5739737 12.93 µM -1.13078373854821 0.13485417366009 no 2942 0.129073062965104 4244 2262825 SGTC_1758 st042942 75.2445 µM -1.13174422675299 0.13465304410106 no 2943 0.128870990962957 4193 669317 SGTC_1859 st055998 20 µM -1.13342314380984 0.134301967711054 no 2944 0.128518299774631 4189 676301 SGTC_1843 st055809 45.5 µM -1.13530052558389 0.133910135663019 no 2945 0.128124711043434 4285 16413835 SGTC_1546 5-methoxyflavanone 78.7 µM -1.13727255684797 0.133499395962047 no 2946 0.12771218169493 4232 147795 SGTC_2824 7998404 51.95 µM -1.1372940325897 0.133494927714438 no 2947 0.127707694270889 4194 837851 SGTC_1206 3978-0017 132 µM -1.13731003956518 0.133491597366457 no 2948 0.127704349634111 4311 3873677 SGTC_1863 st057641 20.1 µM -1.13996510348458 0.132939985948488 no 2949 0.127150419923399 4246 3921635 SGTC_3072 9116419 49.47 µM -1.1447311607252 0.131953739610197 no 2950 0.126160269577882 4279 17170162 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.14503930627605 0.131890148798703 no 2951 0.126096437707071 4119 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_851 0394-0702 453 µM -1.14524436735246 0.131847842849896 no 2952 0.12605397210341 4231 762646 SGTC_2498 4'-Methoxychalcone 54.63 µM -1.14893464979733 0.131088104209257 no 2953 0.125291464291861 4226 641818 YHR062C RPP1 SGTC_1322 1348-1070 12 µM -1.1491391335366 0.131046094635877 no 2954 0.125249307026621 4230 6758089 SGTC_2459 5811157 9.22 µM -1.14943484310943 0.130985359885948 no 2955 0.125188359761932 4208 2870684 YBR192W RIM2 SGTC_1714 st033236 13.627 µM -1.15028001695879 0.130811879841941 no 2956 0.125014279273968 4285 2916566 SGTC_1617 st002906 78 µM -1.15103481352505 0.130657084897982 no 2957 0.124858956790338 4224 5150859 SGTC_2118 5526350 200 µM -1.15143138080865 0.130575806982531 no 2958 0.12477740499309 4277 743594 SGTC_1956 st077085 54 µM -1.15217025750613 0.130424464767976 no 2959 0.124625558519651 4278 24208685 SGTC_553 k007-0256 45.7 µM -1.15360996226885 0.130129922364733 no 2960 0.124330056096158 4304 6287000 SGTC_2947 9072639 7.68 µM -1.15468866645431 0.129909537242219 no 2961 0.124108971164364 4232 16488146 SGTC_2397 5161689 200 µM -1.15559709368999 0.129724141166051 no 2962 0.123922998679225 4317 2259942 SGTC_2964 9083345 53.42 µM -1.15584502606046 0.129673573813789 no 2963 0.123872276062884 4234 17741579 SGTC_1654 st012436 41.8 µM -1.15813236013326 0.129207701717241 no 2964 0.123405013010382 4250 4323132 SGTC_2426 5582046 32.21 µM -1.16188708147891 0.128445477868841 no 2965 0.122640667637167 4267 2251934 SGTC_1335 1486-0900 202 µM -1.16438717343702 0.127939683352256 no 2966 0.12213357162261 4245 X1335 SGTC_223 busulfan 5 mM -1.1668968891157 0.127433335392192 no 2967 0.121626006187549 4257 2478 A DNA alkylator. SGTC_1427 4048-4900 550 nM -1.17246401744324 0.126315118032711 no 2968 0.120505405218139 4263 24132586 SGTC_1050 3232-1156 69.3 µM -1.17315964477519 0.126175875897603 no 2969 0.120365895850143 4246 700529 SGTC_1877 wortmannin 25 µM -1.175618742107 0.12568450177332 no 2970 0.119873631338753 4269 312145 A covalent inhibitor of PI 3-kinase. SGTC_98 0074-0023 107.663 µM -1.1870483863639 0.123418172182084 no 2971 0.117604267650822 4280 3563821 SGTC_56 0957-0365 83.25 µM -1.18728504729502 0.123371550303419 no 2972 0.117557602040049 4243 6752360 SGTC_2717 st081029 62.2815 µM -1.18789410445026 0.123251623620392 no 2973 0.117437566353432 4246 5292846 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.18910666790214 0.12301310651882 no 2974 0.117198847417173 4371 688801 SGTC_897 1000-0139 31.4 µM -1.18957890616899 0.122920302572855 no 2975 0.11710597032784 4233 6151020 SGTC_2440 5628896 157.78 µM -1.19015919662492 0.1228063315217 no 2976 0.116991913586322 4251 5522048 SGTC_1620 st003704 16.5 µM -1.19278833951745 0.122290887362213 no 2977 0.116476138963119 4269 2834414 SGTC_1958 st076513 41.9 µM -1.19309599269361 0.122230671271654 no 2978 0.116415890379741 4224 732122 YGL099W LSG1 SGTC_548 1436-0017 110 µM -1.19451287003301 0.121953618546737 no 2979 0.116138704683661 4339 9677137 SGTC_689 0833-0039 98 µM -1.19606450381784 0.121650722209551 no 2980 0.115835694111423 4232 5374726 SGTC_463 ikarugamyin 104 µM -1.19828180653525 0.12121879800342 no 2981 0.115403663468762 4428 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1293 1000-1278 195 µM -1.19924904608272 0.121030720782236 no 2982 0.115215560711018 4313 678847 SGTC_1111 tnp00062 510.699 nM -1.19935360325658 0.121010402213683 no 2983 0.11519524014102 4331 676306 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.20226346585475 0.120445891942857 no 2984 0.1146307334727 4296 16486 A toxic proline analog. SGTC_2768 sulfasalazine 50.2 µM -1.20251192704654 0.120397776819316 no 2985 0.114582623954307 4281 5384001 An antioxidant and salicylic acid derivative. SGTC_554 4483-2211 187 µM -1.20434618441781 0.120042987220237 no 2986 0.114227901466312 4346 747107 SGTC_1763 st044482 94.5 µM -1.20549589734626 0.119820981055847 no 2987 0.114005960440506 4274 88505 SGTC_3187 9109394 49.47 µM -1.2074652959337 0.11944136896876 no 2988 0.113626501151797 4303 17098090 SGTC_2005 4024620 188 µM -1.21021529339455 0.118912713203607 no 2989 0.113098145600081 4258 236743 SGTC_3066 9117245 49.47 µM -1.21531552090602 0.117936631330594 no 2990 0.112122887222548 4346 17176980 SGTC_187 1488-2104 32.728 µM -1.21593977724045 0.117817551589562 no 2991 0.112003931985828 4300 2852859 SGTC_707 0865-0008 204 µM -1.21757882121115 0.11750530150307 no 2992 0.111692033324816 4330 723043 SGTC_1177 0983-0204 23.6 µM -1.22177335095452 0.116708881970203 no 2993 0.110896674424219 4331 766818 SGTC_36 0335-0881 14.2 µM -1.22212273835529 0.11664271652611 no 2994 0.110830607760089 4200 23828853 SGTC_2083 5306046 65.942 µM -1.22237875878073 0.116594249397361 no 2995 0.110782214030561 4300 539837 SGTC_1995 st072814 61.1 µM -1.22256254541988 0.116559465626162 no 2996 0.11074748347946 4258 5769371 SGTC_2908 7930301 100 µM -1.22303645312951 0.116469807005912 no 2997 0.110657964133218 4267 2223178 SGTC_1967 st070177 51.4 µM -1.22467321278717 0.116160524648077 no 2998 0.110349185400792 4339 5729214 SGTC_1163 k060-0048 49.9 µM -1.22856803623757 0.115426903169438 no 2999 0.109616902923448 4290 6809982 SGTC_2811 7967822 32.47 µM -1.22916170188457 0.115315371269042 no 3000 0.109505592454095 4352 2232244 SGTC_472 calcifediol 10 µM -1.22925805150896 0.115297277302756 no 3001 0.109487534856729 4361 5283731 A vitamin D metabolite. SGTC_460 trequinsin 123 µM -1.23137955871724 0.114899380427918 no 3002 0.109090469281325 4387 5537 A vasodilator. SGTC_2760 etidronate 98.04 µM -1.23399734757101 0.114409751468868 no 3003 0.108601946309619 4262 3305 A chelator and antioxidant. SGTC_1954 st077032 68.9 µM -1.23426270621087 0.114360202062682 no 3004 0.108552513949361 4266 698907 SGTC_1313 1220-0047 237 µM -1.23597552133781 0.114040742203106 no 3005 0.108233831392626 4301 3528706 SGTC_2075 5212009 200 µM -1.23657607142999 0.113928883325184 no 3006 0.108122253982876 4237 780898 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.23776363001188 0.113707918033984 no 3007 0.107901858904852 4318 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2557 derrustone 83.84 µM -1.23951301348906 0.113382972478918 no 3008 0.107577786230254 4291 629853 An antioxidant. SGTC_536 3852-0578 10.6 µM -1.24033880376756 0.113229813403692 no 3009 0.107425052788108 4361 2869208 SGTC_3156 9099931 49.47 µM -1.24358274118479 0.112629590162571 no 3010 0.106826585691141 4353 18111053 SGTC_2905 7799065 20.05 µM -1.24537290786906 0.112299331655453 no 3011 0.106497353573614 4213 1296806 SGTC_2719 novobiocin 32.65 µM -1.24582004440958 0.112216949888288 no 3012 0.106415234510082 4362 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_3315 9136395 68.55 µM -1.24600545677778 0.112182801633473 no 3013 0.106381195931744 4309 16876844 SGTC_2732 terfenadine 20 µM -1.24648450657851 0.11209460719947 no 3014 0.106293286881944 4390 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_564 3555-0129 330 µM -1.24679607855571 0.112037272518593 no 3015 0.106236139370928 4215 563260 SGTC_2261 9010538 184.68 µM -1.25071165630686 0.1113185246803 no 3016 0.1055198481018 4337 6457250 SGTC_1630 st005209 31.3 µM -1.25302581268889 0.110895290543274 no 3017 0.105098156428316 4315 3367314 SGTC_965 1291-5240 308 µM -1.25309861951882 0.110881993692502 no 3018 0.105084909194305 4334 2834598 SGTC_2438 5259590 200 µM -1.25428225365358 0.11066598452828 no 3019 0.104869715956562 4343 1201127 SGTC_2526 patulin 37.61 µM -1.25834002480232 0.109927744772815 no 3020 0.104134405979364 4362 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_3118 9124250 49.47 µM -1.26202251018458 0.10926084640727 no 3021 0.103470343284889 4292 1504786 SGTC_841 0251-0215 91.2 µM -1.26444775891981 0.108823224248862 no 3022 0.103034680079754 4365 3888614 SGTC_2095 5432005 200 µM -1.26547584305888 0.108638093248609 no 3023 0.102850401321025 4338 783734 SGTC_1835 st008666 49.2 µM -1.26653869066177 0.10844694051414 no 3024 0.102660143272993 4280 690455 SGTC_327 1273-0057 3.96 µM -1.26911284767934 0.107984982430968 no 3025 0.102200409332607 4235 3108138 SGTC_1025 k007-0731 70 µM -1.27148457607324 0.107560607926294 no 3026 0.101778155576803 4306 6256118 SGTC_2724 maprotiline 69.64 µM -1.27602912170279 0.106750810528042 no 3027 0.100972612421068 4289 4011 A tricyclic antidepressant. SGTC_854 0422-0053 192 µM -1.27750301006117 0.106489124034662 no 3028 0.100712359206403 4363 3596728 SGTC_3322 9139058 2.11 µM -1.2778527640275 0.106427093832553 no 3029 0.100650672957705 4386 4908926 YPR165W RHO1 SGTC_2539 epi(13)torulosol 80 µM -1.27859072174391 0.106296299818369 no 3030 0.100520609483124 4334 6708597 SGTC_3227 9130768 49.47 µM -1.27891663430752 0.106238572758304 no 3031 0.10046320714016 4402 17720899 SGTC_2333 9017922 200 µM -1.27925886415425 0.106177979886113 no 3032 0.100402956613561 4378 3163164 SGTC_3044 9093193 49.47 µM -1.28037588963074 0.105980380734592 no 3033 0.100206484629255 4371 25236277 SGTC_949 1165-0505 146 µM -1.28047608621541 0.10596266919261 no 3034 0.100188874923477 4323 6244267 SGTC_1384 3089-0840 101 µM -1.2818526430478 0.105719554631865 no 3035 0.0999471715936832 4344 1069836 SGTC_703 3875-0075 71.8 µM -1.28206477739941 0.105682125340473 no 3036 0.099909961792152 4396 2850814 SGTC_861 0443-0273 110 µM -1.28301674597864 0.105514276596866 no 3037 0.0997431046320489 4344 6149169 SGTC_99 0109-0120 622.8 µM -1.28435860569159 0.105278010749104 no 3038 0.0995082548070969 4348 759414 SGTC_2469 5655019 90.81 µM -1.28704514116442 0.104806134021988 no 3039 0.0990392773395417 4408 2788239 SGTC_2560 caryophyllene 100 µM -1.28760032043482 0.104708810762454 no 3040 0.0989425638743397 4392 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_3140 9094243 49.47 µM -1.28861144305897 0.104531728545514 no 3041 0.0987666016011455 4320 19291112 SGTC_2800 7887935 81.82 µM -1.29017540061597 0.104258253479346 no 3042 0.0984948825534897 4365 2961002 SGTC_2756 carbadox 75.1 µM -1.29923013869742 0.102685121913642 no 3043 0.0969324806611883 4305 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1831 st055328 12 µM -1.30049583218087 0.102466607389112 no 3044 0.0967155419055593 4350 1103068 SGTC_2367 9070478 135.38 µM -1.3046547261965 0.101750979819141 no 3045 0.0960052221374959 4307 572802 SGTC_2282 7944268 200 µM -1.30635314920588 0.101459778206113 no 3046 0.0957162452404915 4370 2970414 SGTC_3193 9111931 49.47 µM -1.30900109522344 0.101006988651553 no 3047 0.0952669898713322 4363 17087244 SGTC_2191 5911152 200 µM -1.31167912483302 0.100550554892919 no 3048 0.0948142115440949 4388 2875902 SGTC_2458 5808907 16.39 µM -1.31400651169008 0.100155107064477 no 3049 0.09442200645322 4506 2731747 SGTC_48 0382-0018 55 µM -1.31535662218228 0.0999262298876848 no 3050 0.0941950383654582 4415 762596 SGTC_1437 4092-1038 11.6 µM -1.317186955876 0.0996165532684115 no 3051 0.0938879825828881 4443 3977136 SGTC_2295 7971645 200 µM -1.32452865262532 0.0983814492154159 no 3052 0.0926637668139798 4433 2978226 YKL099C UTP11 SGTC_3046 9092212 49.47 µM -1.32852638436804 0.0977136392248071 no 3053 0.0920021366342519 4461 25236637 SGTC_1298 1079-1278 263 µM -1.32928351694366 0.0975875375338767 no 3054 0.0918772251110651 4368 2840950 SGTC_133 0724-0033 378.92 µM -1.34053162846001 0.0957281814855105 no 3055 0.0900362843491749 4227 280309 SGTC_586 0957-0265 8.15 µM -1.3408750866223 0.0956718194648257 no 3056 0.0899805060979613 4268 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1196 1588-0294 184 µM -1.34582820209444 0.0948617187398853 no 3057 0.0891789639837123 4427 6144269 SGTC_60 0986-0278 202 µM -1.34861534088765 0.0944080996696708 no 3058 0.0887302752938245 4350 3110598 SGTC_29 0299-0004 12.984 µM -1.36115570045804 0.0923868804694612 no 3059 0.0867322451554844 4314 16871 A napthoquinone isolated from Swertia calycina. SGTC_991 3996-0057 64.7 µM -1.36749535279531 0.0913773419560334 no 3060 0.0857350464559569 4439 715343 SGTC_1641 st009299 47.1 µM -1.3682606936875 0.0912560229423921 no 3061 0.0856152447782153 4335 4046054 SGTC_377 3970-0964 33.1 µM -1.36990425076058 0.0909958960260232 no 3062 0.0853583963143099 4411 16481235 SGTC_1119 parthenolide 318.541 nM -1.3739808549832 0.0903530637899452 no 3063 0.0847238130441652 4466 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_628 1636-0253 16 µM -1.37445930866091 0.0902778389912042 no 3064 0.0846495673000639 4405 4456143 SGTC_857 0438-0306 1.35 µM -1.38170020935532 0.0891450623692984 no 3065 0.0835318850473902 4477 4686136 SGTC_2805 7950783 58.44 µM -1.3836420568858 0.0888430833760428 no 3066 0.0832340418951907 4416 1178958 YDL195W SEC31 SGTC_3138 9097216 49.47 µM -1.38693678427385 0.0883324599699806 no 3067 0.0827305199977994 4360 25237486 SGTC_1190 1486-1332 13 µM -1.39052392320485 0.0877790084148097 no 3068 0.0821849199601462 4426 4150046 SGTC_827 3253-0474 693 µM -1.39163491376968 0.0876081219199083 no 3069 0.0820164903636191 4438 5402065 SGTC_1268 0828-0275 2.46 µM -1.39549315592172 0.0870165960219628 no 3070 0.0814335886125091 4467 745337 SGTC_2365 9042475 200 µM -1.39569389959552 0.0869859008775827 no 3071 0.0814033460689386 4475 6464479 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.39966752766524 0.086379968182563 no 3072 0.0808064510601151 4436 688798 SGTC_200 k038-0079 37.545 µM -1.40331655180587 0.0858263189176249 no 3073 0.0802612323129367 4434 3436683 SGTC_401 neomycin 50 µM -1.40534640068658 0.0855194914214268 no 3074 0.0799591484071942 4445 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1297 1068-0111 14.1 µM -1.40612117719275 0.0854025947654864 no 3075 0.0798440724558133 4442 767057 SGTC_2189 6047310 154.431 µM -1.40874394212971 0.0850077657952075 no 3076 0.0794554482197322 4424 711535 SGTC_3126 9127922 49.47 µM -1.41250576847272 0.0844438541352156 no 3077 0.0789005466993554 4436 45595682 SGTC_2 0422-0095 29 µM -1.41616910793245 0.0838974079382078 no 3078 0.0783629991270539 4345 6790840 SGTC_2855 9016525 58.44 µM -1.42170606595115 0.0830765276748153 no 3079 0.0775557992164268 4393 43811474 SGTC_2821 7996764 71.43 µM -1.42459676414566 0.0826503751228177 no 3080 0.0771368979754371 4456 2987135 SGTC_758 0868-0029 16 µM -1.42963693058063 0.0819112819302908 no 3081 0.0764106251772055 4420 762687 SGTC_2893 9048488 25.97 µM -1.43023998404963 0.0818231844662604 no 3082 0.0763240766425213 4487 6467338 SGTC_1105 epirubicin 18.1 µM -1.43224846984717 0.0815302884714595 no 3083 0.0760363623329798 4493 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_158 k038-0087 26.446 µM -1.43277902653536 0.0814530499516087 no 3084 0.0759604984690374 4369 X158 SGTC_1443 4112-3303 14 µM -1.43330337362192 0.0813767696600233 no 3085 0.0758855791504534 4498 704433 SGTC_1821 st053465 65.6 µM -1.43384354362598 0.0812982438620036 no 3086 0.0758084578925376 4471 675086 SGTC_661 1304-0007 33.6 µM -1.43808591481952 0.0806835065833406 no 3087 0.075204839289192 4473 3117130 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.44121342979862 0.0802325692154315 no 3088 0.0747621977188501 4381 5711223 A potent inhibitor of glutathione S-transferases. SGTC_336 4111-0029 111 µM -1.44860137580785 0.0791749136972995 no 3089 0.0737244683846822 4485 3131175 SGTC_403 arphamenine a 50 µM -1.45126618103297 0.0787960229654814 no 3090 0.073352877283364 4472 5487158 An arginine aminopeptidase inhibitor. SGTC_3212 9128307 49.47 µM -1.45641515266489 0.0780678194005804 no 3091 0.0726389446225492 4375 27243542 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.46324382199003 0.0771099512275793 no 3092 0.0717003368314778 4462 6312947 SGTC_1989 st071868 50.2 µM -1.46424017882646 0.076970940530647 no 3093 0.0715641678459449 4450 16414057 SGTC_2567 aureobasidin a 60 nM -1.46428177957707 0.0769651405813487 no 3094 0.0715584867192788 4554 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_305 1682-2595 20.8 µM -1.46524432921455 0.0768310352896374 no 3095 0.0714271345876653 4487 226033 SGTC_35 0133-0054 64.071 µM -1.46728122684716 0.0765478344591916 no 3096 0.0711497842235225 4446 99677 SGTC_1233 0325-0408 14.2 µM -1.46995968173302 0.0761766439162963 no 3097 0.0707863369750435 4515 12874 SGTC_1798 st045719 60.953 µM -1.47245142040986 0.0758325607926351 no 3098 0.0704495081408685 4431 3980186 SGTC_2419 paclitaxel 166.5 µM -1.47394729128031 0.0756265659683744 no 3099 0.0702478916680761 4424 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_747 3448-8087 38.7 µM -1.47454296416722 0.0755446552607141 no 3100 0.0701677293299809 4520 5168703 SGTC_993 3909-8757 62.7 µM -1.47684625466328 0.0752285667953881 no 3101 0.0698584272306714 4433 4288324 YLR208W SEC13 SGTC_2140 5586273 200 µM -1.4821459123891 0.07450510674595 no 3102 0.0691507373012517 4458 854421 SGTC_486 niguldipine 82 µM -1.48351242898608 0.0743194266560091 no 3103 0.0689691583529031 4563 1236 A calcium channel blocker. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.48771783827573 0.0737502191685982 no 3104 0.0684126606208444 4511 6708784 An antioxidant flavonoid SGTC_378 3970-0959 8.33 µM -1.48813179334105 0.0736943704662028 no 3105 0.0683580701807934 4503 6615653 SGTC_3169 9102970 49.47 µM -1.4896178957007 0.0734941394775259 no 3106 0.0681623669206761 4559 17027839 SGTC_2131 toluylene red 5.2905 µM -1.48985951780528 0.073461623719475 no 3107 0.0681305888733135 4440 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1912 st060209 90.8 µM -1.49270752615557 0.0730791879666823 no 3108 0.0677568812209822 4470 688787 SGTC_275 trichlorophene 5.69 µM -1.49667042351788 0.0725495802622469 no 3109 0.0672395178864249 4529 62616 SGTC_177 1327-0068 8.361 µM -1.49780638792487 0.0723983116715108 no 3110 0.0670917803379146 4478 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2077 5212015 200 µM -1.50219980411623 0.0718155444539416 no 3111 0.0665227577065638 4409 780900 SGTC_647 0140-0236 81 µM -1.50379151671621 0.071605300957553 no 3112 0.066317528087654 4514 990837 SGTC_107 0358-0022 2.6945 µM -1.50536346557699 0.0713981317742606 no 3113 0.0661153282862063 4523 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1975 st070967 30.8 µM -1.50674368121757 0.0712166109266703 no 3114 0.0659381851806783 4484 261391 SGTC_2105 5350118 200 µM -1.50980870961647 0.0708147770176331 no 3115 0.0655461210053844 4473 2133313 SGTC_1388 3346-4487 254 µM -1.51623340019278 0.0699781370544157 no 3116 0.0647301726385117 4568 3345614 SGTC_1109 tnp00067 928.257 nM -1.5182982897746 0.0697108629673754 no 3117 0.0644696093169575 4502 676295 SGTC_1173 0443-0020 122 µM -1.51886786218116 0.0696372774037849 no 3118 0.0643978799589121 4496 5331295 SGTC_2200 6600604 21.907 µM -1.52134737872938 0.0693176344042438 no 3119 0.0640863432759543 4537 2904777 SGTC_215 1287-0124 461.5 µM -1.52387507509341 0.0689929449571742 no 3120 0.0637699604412637 4530 5560863 SGTC_1491 4138-0063 26.5 µM -1.52434133999827 0.0689331802320564 no 3121 0.0637117326646323 4513 23883227 SGTC_419 nsc-638432 893 µM -1.52646695832172 0.0686612290730369 no 3122 0.0634468065903147 4477 368090 SGTC_1777 st045864 34.765 µM -1.52740355654739 0.0685416638239324 no 3123 0.0633303463095109 4523 4691462 SGTC_814 3342-0569 96 µM -1.53134359139104 0.0680404409029323 no 3124 0.062842248695614 4551 4346283 SGTC_1336 1486-0901 104 µM -1.53328098743314 0.0677950194152169 no 3125 0.0626033185322881 4517 5006114 SGTC_1862 st057513 3.81 µM -1.53625603123505 0.0674194847449961 no 3126 0.0622377993283845 4493 5393163 SGTC_2137 5261020 140 µM -1.53875687120749 0.0671050535146374 no 3127 0.0619318312670284 4505 763655 SGTC_1282 0886-0010 32.4 µM -1.53986514832595 0.0669660727131043 no 3128 0.0617966138083598 4530 2836211 YNL267W PIK1 SGTC_245 methotrexate 289.6 µM -1.5420607534357 0.0666913957637436 no 3129 0.0615294154497168 4466 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_700 3453-2283 142 µM -1.54436245075095 0.0664043833035121 no 3130 0.0612502756193892 4549 565664 SGTC_530 4358-1714 28 µM -1.55095022560759 0.065588198951309 no 3131 0.0604568063310519 4507 1564641 SGTC_1686 st019653 115.5 µM -1.55317164591897 0.0653147394496791 no 3132 0.0601910666378868 4514 97252 SGTC_2926 9010726 65.15 µM -1.55565508057278 0.0650100736925548 no 3133 0.059895066712909 4509 2994293 SGTC_650 1328-0195 38 µM -1.56067125342189 0.0643980589659484 no 3134 0.0593006686243945 4535 2780821 SGTC_3223 9129970 49.47 µM -1.57102921925372 0.0631484765030278 no 3135 0.0580879309495875 4542 17248386 SGTC_1833 st055984 71 µM -1.57199800071824 0.063032575288209 no 3136 0.0579755074405504 4568 676288 SGTC_2587 piperic acid 92.2 µM -1.57264422968757 0.0629553551589271 no 3137 0.0579006100889748 4468 5370536 SGTC_355 1311-2252 105 µM -1.57274942474634 0.0629427920158594 no 3138 0.057888425278394 4508 5338538 SGTC_2521 angolensin 13.4 µM -1.57938409050304 0.0621543719284802 no 3139 0.0571239921533987 4562 821428 A flavenoid. SGTC_2279 7948423 32.93 µM -1.58117170497878 0.0619432665755935 no 3140 0.056919391537453 4472 1247112 SGTC_1891 st059073 26.2 µM -1.58350870092287 0.0616681273685353 no 3141 0.0566527825418591 4602 688754 SGTC_2054 5233173 129 µM -1.58515194345167 0.0614752371679037 no 3142 0.0564659080785295 4534 6889 SGTC_2885 9057732 51.95 µM -1.59021233355502 0.0608841880752814 no 3143 0.0558934756740038 4540 6471414 SGTC_438 sphingosine 6.67 µM -1.59420542897053 0.0604209418953569 no 3144 0.0554450154780153 4483 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2966 9084041 48.03 µM -1.59434490102946 0.060404811480826 no 3145 0.0554294030212851 4488 17741380 SGTC_1621 st003705 32.4 µM -1.59549771268932 0.0602716139294157 no 3146 0.0553004905413803 4558 24207032 SGTC_2232 chlorophetanol 41.5365 µM -1.59560316164831 0.0602594416871629 no 3147 0.0552887106035166 4625 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1603 st002045 67.8 µM -1.59837754467027 0.059939878374446 no 3148 0.0549794895090785 4531 5887985 SGTC_713 1488-1073 324 µM -1.60361177706169 0.0593405965484727 no 3149 0.0543998265778024 4593 3312542 SGTC_1143 3454-2408 5.08 µM -1.60575105366817 0.0590970213301639 no 3150 0.0541643094686289 4548 X1143 SGTC_387 norethindrone acetate 66.7 µM -1.60975371152116 0.0586433910112266 no 3151 0.0537258170397984 4558 541197 SGTC_2353 9059630 146.67 µM -1.61176123381572 0.0584169055451871 no 3152 0.0535069534915936 4589 4779114 SGTC_2381 9035592 200 µM -1.62384603478095 0.0570679996228321 no 3153 0.0522043361854087 4564 4749657 SGTC_2136 5328288 199.296 µM -1.62644473913203 0.0567811606746865 no 3154 0.0519275400014153 4532 262395 SGTC_2253 7938677 135.83 µM -1.62827635324755 0.0565796744933075 no 3155 0.0517331505922442 4596 2301972 SGTC_795 0685-0265 78 µM -1.63519917032417 0.055823216315163 no 3156 0.0510036510190469 4558 302754 SGTC_2766 oltipraz 83.91 µM -1.63599552353303 0.0557367127604067 no 3157 0.0509202621373436 4531 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_348 k064-0012 10.7 µM -1.64350681134946 0.0549259970664452 no 3158 0.0501390586199846 4526 5066323 SGTC_1328 1441-0025 69.2 µM -1.64391826327272 0.0548818584829915 no 3159 0.0500965435667685 4588 4562601 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.64542046674638 0.0547209472904955 no 3160 0.049941565863199 4536 1241132 A phosphatase inhibitor. SGTC_1946 st076057 65.1 µM -1.6469218335017 0.0545604986234901 no 3161 0.0497870567558135 4560 953009 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.64859195236934 0.054382453047035 no 3162 0.0496156292692839 4498 17037758 SGTC_2835 9006588 71.43 µM -1.65294274604992 0.0539207879183407 no 3163 0.049171258193565 4529 2345538 SGTC_1741 st038134 10.228 µM -1.65510396012204 0.053692616636001 no 3164 0.0489517058675239 4579 1272587 SGTC_2195 6536160 144.242 µM -1.6608836210137 0.0530861821570418 no 3165 0.0483684112028257 4574 3834386 SGTC_1706 st031321 9.9705 µM -1.67356823685359 0.0517742831278417 no 3166 0.0471077426766772 4604 6103185 SGTC_3013 9080133 71.4286 µM -1.6753998712872 0.0515869949804223 no 3167 0.0469279009306145 4617 17050193 SGTC_195 4234-0266 16.654 µM -1.67541615509119 0.0515853323491331 no 3168 0.0469263045539845 4598 2303354 SGTC_1387 3342-1166 1.8 µM -1.67685517532702 0.0514385717037042 no 3169 0.0467854026392618 4574 3418228 SGTC_2683 piperine 63.03 µM -1.68090444273305 0.0510273824813762 no 3170 0.0463907384462612 4609 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2561 acetosyringone 100 µM -1.6873264788426 0.0503806160958413 no 3171 0.0457702961051536 4541 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2514 salinomycin 42.74 µM -1.69070541524127 0.0500429539061781 no 3172 0.0454465397710837 4598 23682228 A polyether potassium ionophore. SGTC_2774 tamoxifen 10.92 µM -1.69297644568879 0.0498170221691129 no 3173 0.0452299753740445 4573 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_726 3448-4391 34.2 µM -1.69577595746971 0.0495396354090328 no 3174 0.0449641586567637 4644 1356692 SGTC_2343 7990716 14.84 µM -1.69717395410368 0.0494015785615514 no 3175 0.0448318888936685 4595 6456862 SGTC_1383 3049-0032 20.7 µM -1.69757426427616 0.0493621032079772 no 3176 0.0447940717807117 4618 712864 SGTC_566 0958-0068 16.5 µM -1.70233309527915 0.0488947523871122 no 3177 0.0443464720732737 4498 6815365 SGTC_2058 5236698 133 µM -1.70259850745198 0.0488687914888098 no 3178 0.0443216147960223 4558 766665 SGTC_1701 st028638 40.4 µM -1.7057659821153 0.0485598190127508 no 3179 0.0440258295667064 4596 3490878 SGTC_869 0564-0080 44.1 µM -1.70590896888676 0.048545908245684 no 3180 0.0440125148114147 4585 6843321 SGTC_927 2425-1185 123 µM -1.71429889242981 0.047735240121627 no 3181 0.0432369232286029 4549 730375 SGTC_3009 9080819 71.4286 µM -1.71760518463198 0.0474187657829939 no 3182 0.0429343270075276 4605 17027216 SGTC_480 am 92016 50 µM -1.72103896707061 0.047091870130373 no 3183 0.0426218765527513 4605 2129 K+ channel blocker. SGTC_524 r073-0010 27.8 µM -1.72375048865463 0.0468350123622055 no 3184 0.0423764480935016 4548 2772106 SGTC_520 3584-0023 682 µM -1.72420029077421 0.0467925122562858 no 3185 0.042335845836224 4577 1340790 SGTC_17 0960-0276 49.807 µM -1.72712893789452 0.0465165513939421 no 3186 0.0420722547847291 4597 6821114 SGTC_1011 4112-3381 17.4 µM -1.73173415019152 0.0460852544309912 no 3187 0.0416604536531863 4624 2877139 SGTC_2305 7443522 69.23 µM -1.74111387058381 0.0452167405584555 no 3188 0.0408318102458329 4509 5415886 SGTC_1562 morin hydrate 59.1 µM -1.74309428904191 0.0450350584312224 no 3189 0.0406585730151596 4597 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_428 3448-4153 16.5 µM -1.76535511909977 0.0430330250399232 no 3190 0.0387520506431919 4588 3834874 SGTC_1377 2944-0135 198 µM -1.76879197624175 0.0427304378022912 no 3191 0.0384642981358304 4610 1894137 SGTC_138 0850-0259 40.9225 µM -1.77227120619527 0.0424258741757991 no 3192 0.0381747742628717 4562 6813004 SGTC_1955 wogonin 32.4 µM -1.7800119814078 0.0417545624305245 no 3193 0.0375369999470175 4593 5281703 A flavanone. SGTC_871 0574-0004 149 µM -1.78372999585036 0.0414351931655734 no 3194 0.0372337747777837 4575 9551173 SGTC_23 0213-0011 39.996 µM -1.78829242262578 0.0410459988130156 no 3195 0.0368644208660184 4614 627608 SGTC_3158 9100007 49.47 µM -1.7917107993617 0.0407563438429742 no 3196 0.0365896518686676 4628 19297233 SGTC_2362 9071156 126 µM -1.79222340880443 0.0407130514160144 no 3197 0.0365485931717534 4609 653133 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.79835262640208 0.0401982936067298 no 3198 0.036060572483317 4642 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1710 st031758 61.5 µM -1.80640068417541 0.0395304253342982 no 3199 0.0354278873982997 4661 5394341 SGTC_44 0929-0055 61.211 µM -1.81170385503375 0.0390952951016063 no 3200 0.0350159838282545 4482 1379590 SGTC_2465 5809242 33.21 µM -1.81924582915184 0.0384831925933227 no 3201 0.0344369669063267 4682 2731748 SGTC_1652 st011932 78 µM -1.82125876714175 0.0383211508903821 no 3202 0.0342837655266103 4585 1551076 SGTC_972 1319-0219 195 µM -1.82267431402836 0.0382075327137886 no 3203 0.0341763664214 4623 23903702 SGTC_2618 avocadyne 43.43 µM -1.82630927914486 0.0379170320582985 no 3204 0.0339018441521282 4585 3015189 SGTC_1588 farnesol 29.9 µM -1.82648871799653 0.0379027383970619 no 3205 0.0338883395664235 4655 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_741 4582-0002 126 µM -1.82770257190899 0.0378061611883298 no 3206 0.0337971009720823 4646 2912688 SGTC_1509 1326-1131 80 µM -1.83058651026562 0.0375775131973508 no 3207 0.0335811417663427 4620 768313 SGTC_760 0568-0725 82.9 µM -1.83851246477076 0.0369549284337991 no 3208 0.0329934634122223 4638 3916171 SGTC_161 4065-0411 162.148 µM -1.84619727586904 0.0363593624055384 no 3209 0.0324317831838466 4627 1906281 YLR208W SEC13 SGTC_2589 lobaric acid 100 µM -1.85250798496784 0.0358761829806077 no 3210 0.0319764560058594 4571 73157 A novel microtubule depolymerizer. SGTC_1235 benzylparaben 21.5 µM -1.8534891125832 0.0358015376011151 no 3211 0.0319061426129379 4683 7180 SGTC_2767 sibutramine 71.45 µM -1.85376140072202 0.0357808441638164 no 3212 0.031886651492148 4625 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1040 k898-0338 155 µM -1.85582703765032 0.0356241782663021 no 3213 0.0317391077039934 4620 20969351 SGTC_1479 0549-0158 134 µM -1.85623887345137 0.0355930103700076 no 3214 0.0317097587458852 4688 5440202 SGTC_510 ag-490 170 µM -1.87108407257546 0.0344843608414736 no 3215 0.030666714438812 4737 5328779 SGTC_1827 berberine 7.24 µM -1.87467789738102 0.0342202806223799 no 3216 0.030418524696365 4580 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2351 9026858 72.31 µM -1.87563038834964 0.0341505693661004 no 3217 0.0303530253176485 4567 1409300 SGTC_1779 st039427 55 µM -1.87777104987624 0.0339943238474324 no 3218 0.0302062461291222 4639 1124498 SGTC_3345 9148410 3.559 µM -1.88017321544765 0.0338196918130221 no 3219 0.030042237364622 4590 4903596 SGTC_2244 6635614 200 µM -1.88735331864295 0.0333021096683285 no 3220 0.0295564097042637 4627 836499 SGTC_1121 fusaric acid 630.51 nM -1.89010430163213 0.033105539772774 no 3221 0.0293720059639487 4633 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_735 3076-0345 636 µM -1.89067701903749 0.0330647370399242 no 3222 0.0293337359949904 4646 2888990 SGTC_344 k064-0035 6.43 µM -1.89594282909586 0.0326915177662004 no 3223 0.028983802371734 4596 5088750 SGTC_2455 5377712 9.75 µM -1.89627063294982 0.0326683996784016 no 3224 0.028962133721333 4649 2243908 SGTC_280 3448-3607 3.04 µM -1.91490388967161 0.0313763009713154 no 3225 0.0277523808431449 4636 626179 SGTC_3080 9117754 49.47 µM -1.91711589852065 0.0312257572382054 no 3226 0.0276116046400503 4655 9550191 SGTC_1424 4048-1941 275 µM -1.91879288755018 0.0311120241779462 no 3227 0.0275052751708271 4716 X1424 SGTC_2028 5153890 36.43 µM -1.93030683359882 0.0303403717296757 no 3228 0.0267844154193222 4649 2830968 YPR165W RHO1 SGTC_953 1188-0045 9.7 µM -1.93415495402803 0.0300860376316983 no 3229 0.0265470394748978 4631 6144426 SGTC_1751 st044839 27.194 µM -1.93996083175072 0.0297056566580766 no 3230 0.026192225096166 4694 5291326 SGTC_2661 dactinomycin 12.96 µM -1.94679881376656 0.0292627822002693 no 3231 0.0257794296225869 4678 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_3008 9078912 71.4286 µM -1.95447536495219 0.0287721443490692 no 3232 0.0253225127447303 4668 16648731 SGTC_2796 7949634 45.45 µM -1.96045426813146 0.0283947647355372 no 3233 0.024971359105692 4636 2971588 SGTC_2321 7390090 138.78 µM -1.96192569247716 0.0283025247927994 no 3234 0.0248855680455049 4667 649046 SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.9802571873249 0.0271741304710401 no 3235 0.0238373184281621 4680 140250 A respiratory chain inhibitor. SGTC_461 N-acetylfarnesylcysteine 136 µM -1.98077475270774 0.0271428246395732 no 3236 0.0238082696737067 4718 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1354 1498-1681 81 µM -1.98782662800047 0.0267192698103472 no 3237 0.0234154338403327 4704 5754243 SGTC_447 ml7 120 µM -2.00653105582483 0.0256224958379498 no 3238 0.0223998093876009 4725 4216 Selective myosin light chain kinase inhibitor. SGTC_1126 isoteolin 1.0172 µM -2.00760612248287 0.0255606195880176 no 3239 0.0223425817247381 4638 133323 SGTC_599 1935-0052 86.5 µM -2.01844174064627 0.0249439245190302 no 3240 0.0217726379649394 4690 9557311 SGTC_879 0831-1030 162 µM -2.02908429526607 0.0243504103787888 no 3241 0.02122485260603 4698 1549252 SGTC_1116 jasmonic acid  1.58368 µM -2.0382004251404 0.0238514930617972 no 3242 0.0207649465065422 4728 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1202 1988-0068 29.6 µM -2.04286533167788 0.023599528584817 no 3243 0.0205328855224092 4678 2850480 SGTC_2528 xanthyletin 44.79 µM -2.05651469766945 0.0228751135233856 no 3244 0.0198664655303161 4699 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2597 laccaic acid a 100 µM -2.05996738406452 0.022694866488536 no 3245 0.0197008294896029 4638 5491415 A textile dye. SGTC_1953 st076800 12.1 µM -2.06548452487218 0.022409330200518 no 3246 0.0194385891398569 4659 297591 SGTC_2033 5192550 145 µM -2.08267851084007 0.021538829599958 no 3247 0.0186402687443895 4696 182073 SGTC_915 methyl methanesulfonate (MMS) 110 mM -2.09095594842166 0.0211300556246961 no 3248 0.0182660065157331 4707 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_3331 9141060 1.957 µM -2.09954372324787 0.0207129120997335 no 3249 0.0178844988722337 4681 4906567 YPR165W RHO1 SGTC_1571 st070080 73.4 µM -2.10063166298849 0.0206605674823243 no 3250 0.0178366561736772 4694 4315245 SGTC_1058 3448-5425 97.3 µM -2.10365216739835 0.0205158273579205 no 3251 0.0177043998917167 4676 7279705 SGTC_224 benfluorex 43.875 µM -2.11166645323267 0.0201359471774276 no 3252 0.0173575341643998 4721 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2572 astragaloside iv 100 µM -2.11281851105139 0.0200818326712865 no 3253 0.0173081523347142 4656 45006101 An anti-inflammatory agent. SGTC_2864 9034755 47.6 µM -2.11469441435435 0.0199939816258851 no 3254 0.0172280003719454 4678 4930451 SGTC_176 1486-1328 72.834 µM -2.11673097301891 0.0198989762071751 no 3255 0.0171413432937809 4707 22310231 SGTC_2457 5731572 11.68 µM -2.12339734167248 0.019590665124147 no 3256 0.01686028489205 4727 2865357 SGTC_3282 9108498 15.4605 µM -2.12473611975904 0.0195292399449084 no 3257 0.0168043188792606 4694 16459645 SGTC_165 k038-0023 64.381 µM -2.12701929915588 0.0194248615526022 no 3258 0.0167092398496601 4677 46368543 SGTC_2080 5212524 12.4 µM -2.12874183327299 0.0193464277640239 no 3259 0.0166378128560016 4677 260183 SGTC_3347 9188721 44.724 µM -2.12895331825543 0.019336816590299 no 3260 0.01662906140545 4690 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1195 1502-0147 41.1 µM -2.12958965569458 0.0193079219841398 no 3261 0.0166027529080742 4720 817940 SGTC_2348 9022543 33.42 µM -2.13229695441226 0.0191853996176758 no 3262 0.0164912211365065 4715 3162678 YDL140C RPO21 SGTC_3247 9135149 49.47 µM -2.13379685981138 0.0191178043847285 no 3263 0.0164297065353735 4721 8934436 YOR116C RPO31 SGTC_1526 st051518 75 µM -2.13597903332236 0.0190198234821643 no 3264 0.0163405614172134 4686 673993 SGTC_2773 thioridazine 9.09 µM -2.14038895892871 0.0188231182237303 no 3265 0.0161616730330078 4707 5452 An antipsychotic. SGTC_2162 5663267 200 µM -2.14831099909519 0.0184741011686134 no 3266 0.0158445288494754 4718 6456493 SGTC_509 pifithrin 175 µM -2.15298529413342 0.0182707649633386 no 3267 0.0156599171535468 4764 4817 A p53 inhibitor. SGTC_1930 st074634 34.3 µM -2.15628881156762 0.0181282116376925 no 3268 0.0155305601854503 4656 684253 YOR116C RPO31 SGTC_3026 9090633 49.47 µM -2.15793984666938 0.0180573222173642 no 3269 0.0154662544727434 4723 25236842 SGTC_422 cantharidin 155 µM -2.1663822804112 0.0176985178151502 no 3270 0.0151409934352601 4659 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1123 mangostin 811.285 nM -2.16884227970897 0.0175951191299773 no 3271 0.0150473300596215 4713 5281650 An antioxidant. SGTC_1162 k048-0130 20.1 µM -2.17162478624975 0.0174787866754204 no 3272 0.0149419879433676 4719 6797406 SGTC_870 0573-2213 57.6 µM -2.17200344775213 0.017463006279838 no 3273 0.0149277014312725 4724 3916321 SGTC_2957 9076800 11.52 µM -2.18047423378672 0.0171131602174663 no 3274 0.014611163374789 4686 16459615 SGTC_1374 2889-5571 141 µM -2.18185476706185 0.0170567152046517 no 3275 0.0145601265406026 4715 2853281 SGTC_2274 7947094 46.08 µM -2.18411440539153 0.0169646701657105 no 3276 0.0144769212059346 4701 2971028 SGTC_1033 k072-0102 21.3 µM -2.18552426713518 0.0169074556833613 no 3277 0.0144252143213028 4687 5965931 SGTC_709 3807-1509 243 µM -2.18662994153974 0.0168627011313556 no 3278 0.014384774868827 4756 1886677 YPL242C IQG1 SGTC_985 1493-0307 8.71 µM -2.18678610301615 0.0168563883315049 no 3279 0.0143790712203124 4744 3278274 SGTC_738 1315-0003 72.4 µM -2.19351675334752 0.0165862171868225 no 3280 0.0141350844402118 4721 6251474 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -2.20330145271649 0.0162000695253878 no 3281 0.0137867543306795 4737 5357218 A potent inhibitor of glutathione S-transferases. SGTC_27 0485-0001 32.618 µM -2.20366365496354 0.0161859244916288 no 3282 0.0137740034982935 4752 2054479 SGTC_2303 7774051 200 µM -2.22821748858386 0.015251382714742 no 3283 0.0129330077031186 4715 2953184 SGTC_1883 5-benzylidenerhodanine 20 µM -2.23157686923 0.01512719778512 no 3284 0.0128214709094021 4729 1273210 SGTC_1053 3366-3204 134 µM -2.23706079956806 0.0149263422275247 no 3285 0.0126411832865744 4727 3632071 YPR165W RHO1 SGTC_2483 5729050 27.16 µM -2.24125980412904 0.0147741025321904 no 3286 0.0125046255158599 4703 2865180 SGTC_180 1486-1293 102.781 µM -2.24304957823439 0.0147096192933692 no 3287 0.0124468088039394 4679 4140536 SGTC_186 3455-3465 67.277 µM -2.24422253713155 0.0146674905616926 no 3288 0.0124090433364862 4762 755278 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -2.24544241243879 0.0146237869112127 no 3289 0.0123698726284833 4703 5379071 SGTC_248 streptozotocin 5.23457 mM -2.24789314128572 0.0145363248840219 no 3290 0.0122915023168304 4746 5300 DNA alkylating agent. SGTC_142 0335-0849 62.6745 µM -2.25120332373097 0.0144189055121554 no 3291 0.0121863312448106 4683 3889043 YPR107C YTH1 SGTC_759 3486-0358 89.3 µM -2.26305960626523 0.0140050136190277 no 3292 0.0118160075766719 4715 875103 SGTC_1534 6-azauridine 81.6 µM -2.26538727110482 0.0139249708585283 no 3293 0.0117444623824172 4752 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2359 9039622 200 µM -2.28836806411296 0.0131556594024518 no 3294 0.0110580479066654 4720 6463596 SGTC_2280 7785178 200 µM -2.28920537140148 0.0131283370276281 no 3295 0.0110337113306411 4726 2954328 SGTC_354 2783-3500 4.88 µM -2.29621045327117 0.0129016676570928 no 3296 0.0108319255727358 4726 6740761 SGTC_3316 9136639 10.545 µM -2.29663528645087 0.0128880304882351 no 3297 0.0108197919653332 4751 4903665 SGTC_982 1491-0518 27.5 µM -2.30871594278568 0.0125054241862257 no 3298 0.0104796745361958 4732 3091256 SGTC_366 0181-0206 4.31 µM -2.3189854852151 0.0121879502379536 no 3299 0.0101979116794804 4704 274874 SGTC_1454 4239-0054 42.6 µM -2.33746304324893 0.0116342994165153 no 3300 0.00970756020191739 4764 1340767 SGTC_1212 0520-0165 585 µM -2.34199503652081 0.0115018875725968 no 3301 0.00959048500425548 4730 5403258 SGTC_2872 9044037 25.97 µM -2.35358828257225 0.0111691070961176 no 3302 0.00929659608588284 4771 6465195 SGTC_3094 9117742 49.47 µM -2.35399854223872 0.0111574856945269 no 3303 0.00928634196075042 4719 17149698 SGTC_866 0495-0101 262 µM -2.35690808081782 0.0110753686479722 no 3304 0.00921390383907 4743 635694 SGTC_2568 diosmetin 100 µM -2.39829928413669 0.00996286125354518 no 3305 0.00823570047462093 4746 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2607 solasodine 47.35 µM -2.42722796391487 0.00924443528745983 no 3306 0.0076073461720488 4705 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_921 1561-0023 372 µM -2.42887972141243 0.00920481907475706 no 3307 0.00757277796314338 4743 24050882 SGTC_2569 tetrandrine 100 µM -2.43885540570643 0.0089687036106457 no 3308 0.00736693119166256 4740 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1569 carminic acid 40.6 µM -2.45252458096319 0.0086537903221223 no 3309 0.00709288434324264 4771 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -2.45839742210536 0.00852149653357059 no 3310 0.00697793194255417 4767 5393153 SGTC_2087 5276107 200 µM -2.47006486705641 0.00826392680375216 no 3311 0.00675442769239556 4756 144405 SGTC_2098 5376439 882.5 nM -2.49395946115207 0.00775768615421478 no 3312 0.00631634856239097 4775 2844116 SGTC_2785 7756463 72.73 µM -2.49738535652397 0.00768738705678099 no 3313 0.0062556456439596 4739 2201551 SGTC_201 4262-0159 12.803 µM -2.54013172230129 0.006856252045994 no 3314 0.00554053631267948 4779 1341029 SGTC_2302 7771753 200 µM -2.55117363531326 0.00665489789641618 no 3315 0.00536804116411218 4724 2203047 SGTC_273 hydroxyurea 18.1 mM -2.55331993834868 0.00661637157546945 no 3316 0.00533507166656205 4783 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_123 0083-0120 66.675 µM -2.56430961191225 0.00642217957537381 no 3317 0.00516906396205351 4753 16001701 SGTC_181 1447-1644 8.07 µM -2.62472836517046 0.0054420087142904 no 3318 0.00433590592641557 4741 534600 SGTC_137 0438-0332 85.389 µM -2.63518305976114 0.0052866061125593 no 3319 0.0042045958808327 4720 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2989 9073649 71.4286 µM -2.63753394509336 0.00525221001647538 no 3320 0.00417556334769076 4746 21367202 SGTC_132 0417-1715 25.805 µM -2.66885207890337 0.00481261636426581 no 3321 0.00380554808929731 4757 6769098 SGTC_620 0109-0052 432 µM -2.6696429996784 0.00480195253643593 no 3322 0.00379659661523696 4779 493037 SGTC_2601 securinine 100 µM -2.67315643213884 0.0047548358470412 no 3323 0.00375706008148798 4754 442872 A GABA receptor antagonist. SGTC_454 lyso-paf C-16 6.67 µM -2.67335094076664 0.00475223948534613 no 3324 0.0037548821068902 4764 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1057 3448-5381 134 µM -2.71047660498188 0.00427922875041383 no 3325 0.00335932940555466 4767 5497911 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -2.71066613568688 0.00427692604766141 no 3326 0.00335741000304924 4785 4174840 SGTC_2079 5212404 121 µM -2.74743696889584 0.00385059038927103 no 3327 0.00300315262433266 4755 758462 SGTC_656 4090-1979 187 µM -2.8210285781355 0.00310990029198742 no 3328 0.0023934969082024 4794 22330961 SGTC_585 0kpi-0023 191 µM -2.84320614252385 0.00291333503737757 no 3329 0.00223310866212574 4764 64601 SGTC_445 e6 berbamine 66 µM -2.88819592357271 0.00254860798996878 no 3330 0.00193729224976932 4790 6610268 A calcium/calmodulin antagonist. SGTC_1934 st074720 32.6 µM -2.89161950421028 0.00252261990029343 no 3331 0.00191630901001575 4756 17250992 SGTC_1919 st067113 52.3 µM -2.90524735589202 0.002421530351647 no 3332 0.0018348148422139 4762 1268243 SGTC_2988 9073640 71.4286 µM -2.92990096652883 0.00224792114630743 no 3333 0.00169535023563257 4771 9102229 SGTC_3335 9143315 29.6265 µM -2.97541833752249 0.00195673555513952 no 3334 0.00146294619998921 4782 4899691 SGTC_1574 spiramycin 23.7 µM -2.9892809028323 0.00187511863121762 no 3335 0.00139817458991636 4777 6419898 An antibiotic and protein synthesis inhibitor. SGTC_448 monastrol 171 µM -2.98968309596963 0.00187279756659384 no 3336 0.00139633509207461 4719 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2304 7443016 91.4 µM -3.00611792663299 0.00178015652841687 no 3337 0.00132303177938009 4771 939854 SGTC_2314 7727897 200 µM -3.02607627638979 0.00167326831666989 no 3338 0.00123874897589799 4767 900724 SGTC_2940 9060638 45.86 µM -3.09330235489565 0.00135481988870525 no 3339 0.000989711765840275 4773 4027022 SGTC_2467 5474540 200 µM -3.10880577906594 0.00128972314226782 no 3340 0.000939225780134355 4782 5413519 SGTC_1765 st044815 90.4 µM -3.1967610823232 0.00097153438506998 yes 3341 0.000694899945117116 4799 645695 SGTC_226 1,3-diallylurea 8.28947 mM -3.21146763288277 0.000925978094667478 yes 3342 0.000660294229757755 4801 74537 YKL182W FAS1 SGTC_210 3551-0445 56.827 µM -3.2944745068671 0.000703628721027381 yes 3343 0.000493029442575401 4757 2865180 YOR207C RET1 SGTC_2868 9035608 32.47 µM -3.30929192938918 0.00066954665720856 yes 3344 0.000467661288141107 4798 6462614 SGTC_980 1473-0395 201 µM -3.34225142523859 0.000599127036617785 yes 3345 0.000415508750037727 4793 768876 SGTC_2242 6630449 61.2675 µM -3.44998429759309 0.000413896356254772 yes 3346 0.000280309580773179 4798 691249 YDR170C SEC7 SGTC_259 usnic acid 108.925 µM -3.54166890361723 0.000299719591519069 yes 3347 0.00019880210534073 4805 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3342 9147791 14.508 µM -3.5905954626306 0.000251536115429606 yes 3348 0.000164961682218525 4804 1838168 SGTC_1908 st060353 56.5 µM -3.61497717631305 0.000230318469277491 yes 3349 0.000150187041598369 4800 4227716 SGTC_64 000l-0018 272.079 µM -3.65416637623169 0.00019968169965787 yes 3350 0.00012900946103606 4781 6811119 SGTC_2787 5284540 71.43 µM -4.03267668693942 4.69139116871881e-05 yes 3351 2.75725623679225e-05 4799 736958 SGTC_1147 3809-1045 12.3 µM -4.05788760798923 4.24079801185125e-05 yes 3352 2.47592936821636e-05 4804 325925 SGTC_2791 5663188 71.43 µM -5.68037994767775 1.92967709133812e-08 yes 3353 6.71979285027226e-09 4810 54690634