SGTCid condition conc unit MPS1|YDL028C.score MPS1|YDL028C.strain.pval MPS1|YDL028C.strain.significant MPS1|YDL028C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1608 st001473 40.5 µM 3.99914880880675 7.09598831540997e-05 yes 1 3.17853510762465e-05 5 7292267 SGTC_149 3970-0822 46.1 µM 3.52011912654185 0.000409298014412756 yes 2 0.000215676507639957 18 3114250 YBL034C STU1 SGTC_1317 1273-0028 910 nM 3.45171927835254 0.000517236584328344 yes 3 0.000278513466837674 18 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2485 5633444 17.78 µM 3.39053049485172 0.000635541918935512 yes 4 0.000348787466508433 12 5724239 SGTC_6 0844-0013 19.835 µM 3.10467248923835 0.00159453247358382 no 5 0.00095244910808663 25 1584900 SGTC_860 0443-0016 25.1 µM 3.10239907850532 0.00160579196353014 no 6 0.00095979493696926 16 5337942 SGTC_2005 4024620 188 µM 3.09336002503506 0.00165127987704695 no 7 0.00098951943685964 10 236743 SGTC_1549 4'-methoxyflavonol 74.6 µM 3.01734652250473 0.00208280188929142 no 8 0.00127499065635664 5 97141 SGTC_1864 st057645 30.4 µM 2.96239646962156 0.00245590753607669 no 9 0.00152627223001121 11 688666 SGTC_2587 piperic acid 92.2 µM 2.93173946474667 0.00268940504331088 no 10 0.00168534695303492 19 5370536 SGTC_1017 4239-0030 168 µM 2.92054965419569 0.00277950513890402 no 11 0.00174707255574134 8 1149593 SGTC_1863 st057641 20.1 µM 2.90801173780206 0.0028836888250357 no 12 0.00181867342404904 17 3921635 SGTC_470 aa-861 153 µM 2.86476945092662 0.00327057141087108 no 13 0.0020865647413727 30 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_749 1000-0129 128 µM 2.83521036286389 0.00356126530906188 no 14 0.00228977598136393 12 708470 SGTC_3204 9114183 49.47 µM 2.81040974200769 0.00382283486556363 no 15 0.00247392323093273 22 17027248 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 2.78520606199638 0.00410617090290799 no 16 0.00267468579477029 14 66535 A nucleotide analog. SGTC_2580 diallyl disulphide 81.36 µM 2.77880214130797 0.00418109352552579 no 17 0.00272798733678126 26 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_433 pimozide 108 µM 2.77666800166609 0.00420633219126626 no 18 0.00274596222246749 6 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 2.74640833947002 0.00457914167870974 no 19 0.00301258598356925 19 442882 SGTC_2026 5148700 152 µM 2.74470836641687 0.00460093521077752 no 20 0.00302823463273834 17 79838 SGTC_329 k048-0121 21.3 µM 2.73265720361112 0.00475810265376997 no 21 0.00314128410561465 25 6832902 SGTC_158 k038-0087 26.446 µM 2.72211647473686 0.00489947820255516 no 22 0.00324326380434828 57 X158 SGTC_2145 5634607 200 µM 2.6566007917014 0.00586517180570668 no 23 0.00394664257915858 9 308662 SGTC_1937 st074714 47.2 µM 2.63486655236999 0.0062209389843485 no 24 0.00420851838481707 11 17250970 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 2.61080847059267 0.00663691312842523 no 25 0.00451642335550866 21 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_260 nsc-65238 3.989 µM 2.61009608104909 0.00664959686572655 no 26 0.00452583978442844 23 3246252 SGTC_521 r062-0005 13.8 µM 2.60494761672502 0.00674190141815094 no 27 0.0045944153672017 14 2832033 SGTC_1316 1272-0050 65.9 µM 2.59462049184357 0.00693047129881372 no 28 0.00473477075484428 10 7340392 SGTC_1159 4092-0538 61.2 µM 2.5892891473817 0.00702963058712338 no 29 0.00480871505247465 26 717301 SGTC_1092 toremifene 6.32 µM 2.53754385801319 0.00805900899337946 no 30 0.00558166897622551 23 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3302 9125395 16.351 µM 2.53076865541676 0.00820315471352454 no 31 0.00569064440351409 25 17599668 SGTC_2569 tetrandrine 100 µM 2.49689485483884 0.00895832095215963 no 32 0.00626430496121091 28 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1994 st072947 40.9 µM 2.47526560600784 0.00947177493593539 no 33 0.00665685608484866 31 5286565 YDL195W SEC31 SGTC_121 0557-0495 61.343 µM 2.45805774051585 0.00989847114684728 no 34 0.00698453563363675 40 3104427 SGTC_2039 Aminomethylbenzodioxan 200 µM 2.45162479633516 0.0100622438242824 no 35 0.00711064315676285 23 15053 SGTC_2694 st077685 81.9 µM 2.45144658731295 0.0100668142097943 no 36 0.00711416507217458 26 2838096 SGTC_909 3448-9333 149 µM 2.42651982963725 0.0107242067851543 no 37 0.00762220860642936 18 3344074 SGTC_917 harmaline 728.087 nM 2.40022333091374 0.0114579374251866 no 38 0.00819253587384298 30 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_425 3825-7017 13.1 µM 2.36886411444766 0.0123896027047745 no 39 0.00892140381595944 43 3397440 SGTC_1709 st033179 39.1045 µM 2.34259305804673 0.0132199240062013 no 40 0.00957512883066468 21 573381 SGTC_1326 1431-2094 10.8 µM 2.32755879735109 0.0137163943329992 no 41 0.00996777172292557 38 616278 SGTC_3196 9111891 49.47 µM 2.31570608668942 0.014119062871479 no 42 0.0102871609268197 29 18891510 SGTC_2600 tangeritin 87.95 µM 2.2853096363735 0.0151985620909567 no 43 0.0111473391482102 36 68077 A bioactive flavone. SGTC_1473 k844-0725 134 µM 2.26062133318527 0.0161268099824677 no 44 0.011891357781598 51 54682906 SGTC_363 0455-0021 3.06 µM 2.23900464730423 0.0169790488039748 no 45 0.0125778068886729 60 4597466 SGTC_62 0180-0423 3.232 µM 2.23221126357453 0.0172547079761334 no 46 0.0128005016667741 56 30102 YGL099W LSG1 SGTC_2630 antimycin a 100 µM 2.20808186284795 0.0182649369349103 no 47 0.0136192835443977 51 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_663 1486-0733 13.9 µM 2.18672748420139 0.0192006008231792 no 48 0.0143812119881047 38 722445 YPR165W RHO1 SGTC_1104 tacrolimus 29.8 µM 2.1756024305029 0.0197039929930893 no 49 0.0147925007255294 55 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1865 st057639 52.2 µM 2.13171250507861 0.0218006171719054 no 50 0.0165152440841986 37 688818 SGTC_1763 st044482 94.5 µM 2.12990394211709 0.0218909082857294 no 51 0.0165897723135757 53 88505 SGTC_2087 5276107 200 µM 2.12843982604519 0.02196423426782 no 52 0.0166503170357758 37 144405 SGTC_327 1273-0057 3.96 µM 2.12833044055058 0.0219697208366601 no 53 0.0166548479698765 47 3108138 SGTC_2091 4-phenylthiadiazole 200 µM 2.1216198531039 0.0223085311245688 no 54 0.016934836923154 36 270010 SGTC_1193 1488-0126 41.5 µM 2.11934110833203 0.0224245804830278 no 55 0.0170308249554805 38 1384710 SGTC_1712 st032288 53.4 µM 2.11822620861828 0.0224815440810208 no 56 0.0170779572907303 82 2883011 SGTC_1919 st067113 52.3 µM 2.11603739577462 0.0225937321240102 no 57 0.0171708135987559 55 1268243 SGTC_2962 9082311 13.18 µM 2.11033134163815 0.0228884180633677 no 58 0.0174149128962701 61 16459453 SGTC_2364 9055074 200 µM 2.09660454251155 0.0236106188524875 no 59 0.0180142984197382 34 6470630 SGTC_2367 9070478 135.38 µM 2.09106340483674 0.0239075337128356 no 60 0.0182611903117675 53 572802 SGTC_150 3970-0969 77.2 µM 2.08875018700994 0.0240324097988213 no 61 0.018365108282258 83 6615640 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 2.08160125087072 0.0244218049917176 no 62 0.0186894535337935 33 16486 A toxic proline analog. SGTC_1447 4239-0816 81.9 µM 2.07246383666811 0.024927209041889 no 63 0.0191111027032705 59 1341554 SGTC_369 0957-0393 4.5 µM 2.06748473400712 0.0252062828910708 no 64 0.0193442506121341 51 6997992 SGTC_1163 k060-0048 49.9 µM 2.06554550310765 0.0253156810563626 no 65 0.0194357073766375 38 6809982 SGTC_1516 st013856 110 µM 2.06388799330431 0.0254095014741336 no 66 0.0195141687034825 44 5281404 A mutagen and neurotoxin. SGTC_2007 4011539 71.82 µM 2.06279339105553 0.0254716190359658 no 67 0.0195661311126507 34 45595301 SGTC_55 0767-0285 6.563 µM 2.04844100374545 0.0262979356443758 no 68 0.020258403630821 48 3116166 SGTC_1097 itavastatin 7.23 µM 2.04644652443104 0.0264145188330445 no 69 0.0203562293297045 64 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_515 4092-1064 102 µM 2.04108431657404 0.0267300990376024 no 70 0.0206212234952203 69 717353 SGTC_1376 2910-0861 41.3 µM 2.03753027037617 0.0269409943969501 no 71 0.0207984658475278 44 1112859 SGTC_15 0266-0086 27.098 µM 2.0366555585174 0.0269931118278427 no 72 0.020842285496525 64 1712902 YIL048W NEO1 SGTC_2058 5236698 133 µM 2.01465366829164 0.0283319706659059 no 73 0.0219704749795446 39 766665 SGTC_63 0099-0242 26.702 µM 2.00628231464759 0.0288556926129383 no 74 0.0224130679092411 75 3898502 YLR359W ADE13 SGTC_2343 7990716 14.84 µM 1.99596044260905 0.0295124952004928 no 75 0.0229691143625578 54 6456862 SGTC_514 4466-0038 2.65 nM 1.99016938627198 0.0298863953657231 no 76 0.0232861397125486 97 5722064 SGTC_2868 9035608 32.47 µM 1.98721999056559 0.0300783284533606 no 77 0.0234490117488299 42 6462614 SGTC_3113 9123498 49.47 µM 1.9820517793789 0.0304171158850076 no 78 0.0237367228478952 56 8897275 SGTC_2422 chlorphenesin carbamate 384.24 µM 1.97786403764302 0.0306939447693951 no 79 0.0239720234473512 46 2724 A muscle relaxant with antifungal properties. SGTC_1335 1486-0900 202 µM 1.9505890233174 0.0325484125919232 no 80 0.0255529770038672 42 X1335 SGTC_760 0568-0725 82.9 µM 1.94682645362345 0.0328113433252457 no 81 0.0257777721720962 44 3916171 SGTC_1754 st042065 16.137 µM 1.94476541943929 0.0329561103885235 no 82 0.0259016089279917 85 1126236 YIL048W NEO1 SGTC_1046 2001-0062 216 µM 1.94413766230898 0.0330003084976449 no 83 0.0259394263150346 59 739778 SGTC_1082 camptothecin 424.86 nM 1.94325022134247 0.0330628733313926 no 84 0.0259929663928094 80 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3184 9108758 49.47 µM 1.92427839643164 0.0344239373655729 no 85 0.0271598485013772 36 902885 SGTC_1342 1486-1464 234 µM 1.92299984515949 0.0345172943853453 no 86 0.0272400346520024 59 3253938 SGTC_1990 st072050 59.8 µM 1.92066728964985 0.0346881483278069 no 87 0.0273868329728552 46 17233948 SGTC_2294 7971431 200 µM 1.91522232193947 0.0350896826574011 no 88 0.0277320784671951 54 5741572 SGTC_649 1123-0311 367 µM 1.89842109733096 0.0363527749385388 no 89 0.0288203163105261 69 693629 YIL048W NEO1 SGTC_1206 3978-0017 132 µM 1.89591052451809 0.0365446735236093 no 90 0.028985938513805 70 3873677 SGTC_661 1304-0007 33.6 µM 1.89442501364816 0.0366586100527202 no 91 0.0290843094386168 53 3117130 SGTC_1883 5-benzylidenerhodanine 20 µM 1.89227333577526 0.0368241557101297 no 92 0.0292272858468816 62 1273210 SGTC_411 enrofloxacin 100 µM 1.88712981809746 0.0372223655140304 no 93 0.0295714334944649 42 71188 A bacterial gyrase inhibitor. SGTC_2593 nobiletin 86.24 µM 1.86884993965178 0.0386661510385567 no 94 0.0308218473377791 64 72344 An anti-infammatory. SGTC_3316 9136639 10.545 µM 1.86070965011354 0.0393236116118763 no 95 0.0313925951734791 57 4903665 SGTC_1486 3970-0793 4.53 µM 1.85889370315578 0.0394715129109882 no 96 0.0315211034122073 63 2844330 SGTC_233 rapamycin 362 pM 1.85565649982063 0.0397362917721069 no 97 0.0317512674362848 48 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2782 7736369 71.43 µM 1.84719184548543 0.0404354665269792 no 98 0.0323596704052341 72 2950836 YOL077C BRX1 SGTC_582 0987-0078 156 µM 1.84238320099444 0.0408370856230523 no 99 0.032709558646228 69 1625765 SGTC_560 2332-1943 155 µM 1.84227539023515 0.0408461269615516 no 100 0.0327174388228111 65 21177716 SGTC_1127 asiatic acid 681.4 nM 1.84055428042372 0.0409906845007929 no 101 0.0328434514433481 60 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2922 7999257 32.47 µM 1.82898914664056 0.0419728445412935 no 102 0.0337006170815516 61 2988377 SGTC_1591 genipin 88.4 µM 1.82410106453679 0.0423936488483132 no 103 0.0340683973190291 73 442424 A DNA cross-linking agent. SGTC_451 chloral hydrate 100 µM 1.81490590443378 0.043194484633951 no 104 0.0347691855113929 93 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2776 terbinafine 19.92 µM 1.80170328089267 0.0443656628858641 no 105 0.0357960508139307 64 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_579 4491-1009 110 µM 1.79488107215651 0.0449808004254337 no 106 0.0363363251189103 74 1271041 SGTC_1550 gossypolone 36.6 µM 1.79206884460231 0.0452363603504499 no 107 0.0365609693950644 66 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.79076949202107 0.0453548323433318 no 108 0.0366651464297853 61 91467 include heat shock SGTC_1539 benzyladenosine 56 µM 1.78992131364608 0.0454323018420085 no 109 0.0367332809618705 68 92208 A nucleotide analog. SGTC_1238 0333-0287 48.8 µM 1.78729887782486 0.0456724988690533 no 110 0.0369445976557902 46 7226 SGTC_1160 4092-0570 10.5 µM 1.78382683570736 0.0459920833124924 no 111 0.0372259037597932 71 4994975 SGTC_820 1582-0060 59.9 µM 1.76957234073162 0.0473230129251757 no 112 0.0383992049500167 70 3848840 SGTC_1202 1988-0068 29.6 µM 1.76616013595632 0.0476461430379843 no 113 0.0386844934367763 65 2850480 SGTC_1777 st045864 34.765 µM 1.76189870713395 0.0480521721428561 no 114 0.0390432065537658 80 4691462 SGTC_2419 paclitaxel 166.5 µM 1.74937815908195 0.0492611681721105 no 115 0.0401128368300564 82 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2383 9036125 200 µM 1.74629857662225 0.0495622270539439 no 116 0.0403795415425042 61 79580 SGTC_573 3702-0553 84.7 µM 1.7456520293168 0.0496256194086099 no 117 0.0404357177318683 75 1222756 SGTC_191 3914-0123 66.505 µM 1.74109499426049 0.0500742623918483 no 118 0.0408334643301067 76 3144412 SGTC_2280 7785178 200 µM 1.73699212829404 0.0504809531692802 no 119 0.0411942801584303 61 2954328 SGTC_1485 3909-9022 254 µM 1.7324460102402 0.0509346494672003 no 120 0.0415970909875896 54 714516 SGTC_2904 7225135 42.03 µM 1.73036086666095 0.0511438268966243 no 121 0.0417829105094686 82 4446116 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.73010210247644 0.0511698332130301 no 122 0.0418060173370398 60 279621 SGTC_476 mead acid 10 µM 1.7298233730398 0.0511978578475597 no 123 0.0418309185741752 54 5312531 An omega 9 fatty acid. SGTC_320 4092-0846 5.34 µM 1.72685534966201 0.0514970334177743 no 124 0.0420968225373917 93 1359356 SGTC_3198 9112019 49.47 µM 1.72447177661403 0.0517383017994754 no 125 0.0423113548760497 72 45595555 SGTC_2883 9059145 45.46 µM 1.72348406723277 0.0518385419678142 no 126 0.0424005119879152 80 16476510 SGTC_1675 st018485 24.5 µM 1.72145336382287 0.0520451178520395 no 127 0.0425842939536458 82 3323024 SGTC_2051 5263410 176 µM 1.71913788169094 0.0522814606124176 no 128 0.042794634233347 69 227584 SGTC_438 sphingosine 6.67 µM 1.71765232345797 0.0524335407661162 no 129 0.0429300252047258 50 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_68 0986-0284 82.829 µM 1.71655402288094 0.0525462020649971 no 130 0.0430303446196976 66 423278 YIL048W NEO1 SGTC_1612 st002233 45.4 µM 1.71068577449561 0.0531514135996053 no 131 0.0435695675762633 65 1035021 SGTC_655 k060-0012 42 µM 1.7016573626693 0.0540933203453003 no 132 0.0444098087817239 88 5994525 SGTC_2643 anethole 100 µM 1.69864256614348 0.0544107708473068 no 133 0.0446932755371849 83 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2092 5303694 80.6725 µM 1.69563303064774 0.0547291353745381 no 134 0.0449776991861898 82 1963699 SGTC_13 0199-0087 65 µM 1.69443742792396 0.0548560205349135 no 135 0.0450910962016985 76 4589825 SGTC_2391 6285546 200 µM 1.69388223318559 0.0549150204210459 no 136 0.0451438318495779 67 846083 SGTC_1512 0259-0544 12.2 µM 1.69383809380168 0.054919713212184 no 137 0.0451480265955508 87 18476 SGTC_2377 9073351 62.6 µM 1.69040717157746 0.0552854511843905 no 138 0.0454750419916629 87 7337946 YHR072W ERG7 SGTC_870 0573-2213 57.6 µM 1.68956151857525 0.0553758930494064 no 139 0.0455559365931697 70 3916321 SGTC_1674 st016616 23.6 µM 1.68916696590005 0.0554181300717645 no 140 0.045593718803387 70 625830 SGTC_257 daunorubicin 18.5 µM 1.68676585482361 0.0556757186550462 no 141 0.0458241917454399 79 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_504 lovastatin 124 µM 1.67794038133177 0.0566306333490094 no 142 0.0466793691461989 88 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2070 5230947 200 µM 1.67360565774836 0.0571043514353087 no 143 0.047104062929442 71 2835538 SGTC_613 3914-0030 117 µM 1.67269427655362 0.0572043470265348 no 144 0.0471937482735651 38 1145395 SGTC_1477 0139-0234 16 µM 1.67194189527957 0.0572870011498342 no 145 0.0472678901738007 79 620880 SGTC_157 1348-1695 65.819 µM 1.67155758611855 0.0573292563323927 no 146 0.047305797151965 110 5380510 SGTC_2478 5763493 32.33 µM 1.67096255102966 0.0573947294229062 no 147 0.047364537494761 78 1365576 YLR208W SEC13 SGTC_3348 9149464 3.537 µM 1.67095017748504 0.0573960915368417 no 148 0.0473657595995093 55 1951442 SGTC_524 r073-0010 27.8 µM 1.67056698929464 0.0574382865411411 no 149 0.047403618669575 89 2772106 SGTC_743 1275-0778 158 µM 1.66982231093669 0.0575203570505752 no 150 0.0474772623853956 97 2849257 YMR203W TOM40 SGTC_3109 9122853 49.47 µM 1.66803249414503 0.0577179888523751 no 151 0.0476546382323118 74 1234709 SGTC_2869 9037858 32.47 µM 1.66582965907748 0.0579619587065693 no 152 0.0478736734867705 62 27187042 SGTC_752 1896-0090 130 µM 1.66554075436126 0.0579940157068281 no 153 0.0479024599370812 81 772567 SGTC_126 0417-1624 672.48 µM 1.66364190709221 0.0582050595623425 no 154 0.0480920059607909 110 41912 YDL195W SEC31 SGTC_557 1315-0110 16.2 µM 1.65168143130089 0.0595482845360481 no 155 0.0492997549766715 71 6833801 SGTC_3241 9133421 49.47 µM 1.64959153326015 0.0597854650977113 no 156 0.0495132539324662 57 17018221 SGTC_983 1491-0821 12.2 µM 1.649133183425 0.0598375816115837 no 157 0.0495601763765103 76 46495113 SGTC_1978 st071761 42 µM 1.64051638682354 0.0608239894153898 no 158 0.050448922062145 94 5147680 SGTC_627 1391-0720 175 µM 1.63891763614643 0.0610083970313642 no 159 0.050615207112112 88 997839 SGTC_2072 5231554 129 µM 1.6345791738516 0.0615110186520334 no 160 0.0510686482052445 79 789545 SGTC_1672 st016598 6.51 µM 1.63356671902896 0.0616287782013602 no 161 0.0511749303732159 106 4665860 YNL267W PIK1 SGTC_2224 6650123 117.647 µM 1.63121535657211 0.0619029464614329 no 162 0.051422443052013 69 2908370 SGTC_2787 5284540 71.43 µM 1.62776131372259 0.0623074120372131 no 163 0.051787753245127 87 736958 SGTC_1619 st003326 88.7 µM 1.62749444094743 0.0623387481943519 no 164 0.0518160641557704 63 2849032 SGTC_304 1310-0298 97 µM 1.61955358884248 0.0632767969176284 no 165 0.0526641030645544 97 1550234 SGTC_17 0960-0276 49.807 µM 1.61371259186735 0.0639737783111255 no 166 0.0532948907054953 100 6821114 SGTC_2951 9072950 58.06 µM 1.61223046765711 0.0641515800298454 no 167 0.0534558988016517 83 16488155 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.60660018911866 0.0648305146035048 no 168 0.0540710505062061 126 16725076 SGTC_2925 9010536 32.5 µM 1.60485967372042 0.0650415219809665 no 169 0.0542623449657574 65 2994177 SGTC_3140 9094243 49.47 µM 1.60468797806086 0.0650623659600092 no 170 0.0542812444652706 88 19291112 SGTC_1964 st076914 61 µM 1.60189881330233 0.0654016992383167 no 171 0.0545889934850234 105 24208661 SGTC_303 1348-1668 34.2 µM 1.60183220255298 0.0654098199367493 no 172 0.0545963599716565 80 5380509 SGTC_2090 5301565 104.445 µM 1.59665148885619 0.0660438140072176 no 173 0.0551717073952075 98 2056344 SGTC_923 1900-2434 73.3 µM 1.59534164312198 0.0662048590588851 no 174 0.0553179290577861 107 5910570 SGTC_2990 9074105 71.4286 µM 1.59309558239609 0.0664817191513404 no 175 0.0555693751120283 71 6502001 SGTC_450 aminopyrene 156 nM 1.58710547720637 0.0672244709543905 no 176 0.0562443788011809 92 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1199 1638-0010 4.46 µM 1.5858791284656 0.0673773220668871 no 177 0.056383365630919 87 3111136 SGTC_391 gliotoxin 8.33 µM 1.58070421241279 0.0680252794533754 no 178 0.0569728423859965 92 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_3006 9075424 71.4286 µM 1.56869110387312 0.0695479947584289 no 179 0.0583599662470292 85 7465181 SGTC_993 3909-8757 62.7 µM 1.56630893782784 0.0698530396519033 no 180 0.0586381547937632 73 4288324 YLR208W SEC13 SGTC_1664 st014217 9.02 µM 1.56003049222518 0.0706619502471145 no 181 0.0593763378016354 89 3982782 SGTC_929 2805-0021 398 µM 1.55688972393304 0.0710692966588714 no 182 0.0597483348158057 85 3098024 SGTC_270 tamoxifen 5.46 µM 1.55604379573796 0.0711793181959698 no 183 0.0598488392253083 97 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1302 1159-0335 255 µM 1.55566490376491 0.0712286393228546 no 184 0.0598938981571464 81 649284 SGTC_2040 5100729 123 µM 1.55346794155371 0.0715151395894996 no 185 0.0601556911904928 95 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1225 1216-0074 20.6 µM 1.5481803341463 0.0722083077608396 no 186 0.0607894424149263 81 4241466 SGTC_3211 9128781 49.47 µM 1.54666728317926 0.072407602651945 no 187 0.0609717480837471 93 17194361 SGTC_2956 9076196 2.52 µM 1.54506397262392 0.0726192458908238 no 188 0.0611653951417612 89 16423868 SGTC_2979 9012552 45.46 µM 1.54309850365075 0.0728793414735148 no 189 0.0614034388758891 92 17100905 SGTC_1519 esterone 74 µM 1.54299417546114 0.0728931673980618 no 190 0.0614160945677599 94 698 A steroid. SGTC_1956 st077085 54 µM 1.53748082263721 0.0736266759842469 no 191 0.0620878038580905 108 24208685 SGTC_3301 9125354 19.7965 µM 1.53452359369094 0.0740224304817101 no 192 0.0624504467250492 81 41905162 SGTC_612 0302-0167 22.4 µM 1.53201140693175 0.0743599017036107 no 193 0.0627598099525003 101 235821 SGTC_866 0495-0101 262 µM 1.53115871166289 0.0744747140223153 no 194 0.0628650861498935 103 635694 SGTC_2446 5162541 200 µM 1.5250756369468 0.0752977077712845 no 195 0.0636201165648573 85 1549321 SGTC_2714 st079313 56.9 µM 1.52450607046021 0.0753751193529194 no 196 0.0636911707980014 79 2939799 SGTC_1930 st074634 34.3 µM 1.51892168310842 0.0761373271224614 no 197 0.0643911052041009 103 684253 YOR116C RPO31 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.51714737811631 0.0763807244721106 no 198 0.064614739316893 74 521171 SGTC_2992 9074591 71.4286 µM 1.51549952430286 0.076607305203448 no 199 0.0648229753499314 84 17741321 SGTC_3120 9124077 49.47 µM 1.51500458686517 0.0766754590842938 no 200 0.0648856212633294 76 18774327 YGL155W CDC43 SGTC_229 benomyl 22.8748 µM 1.51455853152222 0.0767369212977142 no 201 0.0649421202624401 93 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_77 0828-0286 12.516 µM 1.51212283968365 0.0770731976099119 no 202 0.0652513077621797 91 745345 SGTC_480 am 92016 50 µM 1.51103012578598 0.0772244232061287 no 203 0.0653903877882091 119 2129 K+ channel blocker. SGTC_475 α-linolenic acid 10 µM 1.51045929096338 0.0773035131988284 no 204 0.0654631347096114 110 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_574 1315-0397 40 µM 1.50855187931356 0.0775682341900181 no 205 0.0657066696804608 116 6794277 SGTC_3163 9099914 49.47 µM 1.50777429241565 0.0776763492256929 no 206 0.0658061519025496 89 16268368 SGTC_92 0063-0024 660.874 µM 1.49923498251159 0.0788711849426309 no 207 0.0669063413569779 80 3594437 SGTC_1514 1189-1591 158 µM 1.49306559853469 0.0797430431651815 no 208 0.0677100082371576 101 767698 YMR146C TIF34 SGTC_1870 st057514 26.5 µM 1.49303786892021 0.0797469783092047 no 209 0.0677136372500618 95 5393161 SGTC_3172 9105863 49.47 µM 1.49154153747392 0.07995954245629 no 210 0.0679096871054521 73 2348785 SGTC_1197 1601-0112 267 µM 1.48532589410374 0.080847105082473 no 211 0.0687287578650859 102 7350313 SGTC_2689 tacrolimus 100 µM 1.4839800387814 0.0810402624080874 no 212 0.0689071081233012 97 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_601 0986-0029 62.9 µM 1.48105552500648 0.0814611894212223 no 213 0.0692958890139869 101 24747981 SGTC_1372 2752-0194 270 µM 1.47868567670524 0.0818034908510069 no 214 0.0696121710934057 82 823334 SGTC_652 0437-0092 114 µM 1.47404808378271 0.0824764807427271 no 215 0.0702343226264377 93 3091274 SGTC_2168 5727979 200 µM 1.46584238607989 0.0836774599124061 no 216 0.0713456153808193 104 695210 SGTC_3079 9117512 49.47 µM 1.46560983090166 0.083711686940523 no 217 0.0713773057390999 109 7185044 SGTC_2945 9067681 61.76 µM 1.46526782490301 0.0837620418374042 no 218 0.071423930617505 128 16456930 SGTC_2009 4012297 12.05 µM 1.46520703972837 0.0837709938600689 no 219 0.0714322197641135 103 45595307 SGTC_227 fluconazole 33.516 µM 1.46435124302934 0.0838971060110512 no 220 0.0715490013475667 159 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1071 trifluoperazine 6.31 µM 1.45932986497944 0.0846399417384176 no 221 0.072237169658208 102 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2939 9044578 71.43 µM 1.45911748039609 0.0846714691629333 no 222 0.0722663879022199 98 2653634 SGTC_2166 5933061 31.504 µM 1.4565814818338 0.085048606133577 no 223 0.0726159712331327 84 2877375 SGTC_312 4092-0653 6.84 µM 1.4538398984972 0.0854577310351866 no 224 0.0729953494468979 127 1148278 SGTC_315 k915-0449 187 µM 1.44877449681089 0.0862175128022639 no 225 0.0737002840791923 89 20970215 YNL149C PGA2 SGTC_1357 1503-1303 39.5 µM 1.44667978451473 0.0865331804067122 no 226 0.0739933144400653 102 292895 SGTC_1734 st037168 69.4 µM 1.44432308750758 0.0868893603573729 no 227 0.0743240571833671 108 708907 SGTC_3256 9138902 49.47 µM 1.4390539287141 0.0876896761852456 no 228 0.0750676219289418 94 17228773 SGTC_3053 9095903 49.47 µM 1.43866922738896 0.0877483219617354 no 229 0.0751221310151595 113 17174018 SGTC_1677 st019204 53.9 µM 1.43593477377853 0.0881660189794903 no 230 0.0755104511916617 92 3945625 SGTC_3121 9125696 49.47 µM 1.43120458940628 0.0888920673034113 no 231 0.0761857943163115 78 1235365 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.43018125945308 0.089049724916488 no 232 0.0763325013513558 109 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2153 5569715 200 µM 1.42677275993796 0.0895763507529752 no 233 0.0768227026574164 113 2054701 SGTC_2427 5545055 42.75 µM 1.42349007432741 0.0900857237742367 no 234 0.0772970687172288 109 5372858 SGTC_2726 cimetidine 79.27 µM 1.42165079166571 0.0903720635841306 no 235 0.0775638260047547 95 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2301 7769476 200 µM 1.42137261098317 0.0904154295706308 no 236 0.0776042322578004 111 977820 SGTC_2417 cerulenin 830 nM 1.41970062322636 0.0906764037297516 no 237 0.0778474283097581 110 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_924 2046-0044 21.3 µM 1.4175164771605 0.0910181603612437 no 238 0.0781659901997755 114 3623589 SGTC_748 act1.228 77.9 µM 1.41649307278951 0.0911786223195772 no 239 0.0783155954577835 102 4421505 YNR035C ARC35 SGTC_2240 6690706 185.951 µM 1.4159443489327 0.0912647443581638 no 240 0.0783958994296694 91 805876 SGTC_3192 9110362 49.47 µM 1.41217507112819 0.0918579620150566 no 241 0.0789492093754076 95 16649480 SGTC_2931 9014674 55.67 µM 1.40907933263614 0.0923473086973414 no 242 0.0794058556502238 105 2996810 SGTC_819 1013-0258 27.7 µM 1.40140802509602 0.0935682293411917 no 243 0.0805460469256084 105 5753198 SGTC_1121 fusaric acid 630.51 nM 1.39775423012605 0.09415391952285 no 244 0.0810934415399883 100 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_200 k038-0079 37.545 µM 1.39711312745857 0.0942569642761408 no 245 0.0811897774023098 126 3436683 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.39519229144585 0.094566199150116 no 246 0.0814789304753001 116 676296 Flavone; oxidizing agent. SGTC_1960 st011366 51.8 µM 1.39457494976982 0.094665743458953 no 247 0.0815720267309435 125 3972846 SGTC_2762 leflunomide 42.06 µM 1.39373919049761 0.0948006299100869 no 248 0.0816981885228351 133 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1460 k062-0059 9.15 µM 1.39056461555394 0.095314277683189 no 249 0.0821787462814957 105 1373085 SGTC_178 4092-0806 87.505 µM 1.38045011808441 0.0969644689937613 no 250 0.0837240490266767 134 2169044 SGTC_3051 9093778 49.47 µM 1.37941771282823 0.0971340795172835 no 251 0.0838830005483336 137 17217378 SGTC_2323 6148992 148.28 µM 1.37846854136445 0.0972902078501999 no 252 0.084029337066356 110 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_3268 9137683 49.47 µM 1.37784260864899 0.0973932676389752 no 253 0.0841259437539957 130 1953228 SGTC_298 1391-0729 10 µM 1.37548813624177 0.0977816485911617 no 254 0.0844900806373709 102 3237558 SGTC_714 4296-0578 26.1 µM 1.36841199414638 0.0989557221949653 no 255 0.0855915759966496 102 1589775 SGTC_2507 purpurin 79.67 µM 1.36839959304104 0.0989577887999268 no 256 0.0855935157869379 118 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_880 0833-0487 87.2 µM 1.36815059399947 0.0989992903840453 no 257 0.0856324713719219 115 76075 SGTC_1377 2944-0135 198 µM 1.3614474070875 0.100121324588157 no 258 0.0866861716017695 102 1894137 SGTC_2715 st079500 56.4 µM 1.36122689626183 0.100158392583464 no 259 0.0867209984586279 115 28246688 SGTC_2943 9068529 45.32 µM 1.35939148615875 0.100467314871957 no 260 0.0870112837675627 143 3270634 SGTC_572 0960-0087 17.7 µM 1.3580604758138 0.100691774910805 no 261 0.0872222476560523 163 6796365 SGTC_2016 5121758 140 µM 1.3552964695904 0.101159061671266 no 262 0.0876615596845661 145 2795203 SGTC_460 trequinsin 123 µM 1.35511302374491 0.101190131114303 no 263 0.0876907749400014 121 5537 A vasodilator. SGTC_1572 epiandrosterone 68.9 µM 1.35435067276333 0.101319321755051 no 264 0.0878122634088978 108 441302 A steroid. SGTC_2400 5203494 178.7 µM 1.3543398336469 0.101321159455317 no 265 0.0878139916382994 143 6777674 SGTC_1437 4092-1038 11.6 µM 1.35321700602828 0.101511659001305 no 266 0.0879931569569866 127 3977136 SGTC_1026 k007-1105 30.6 µM 1.35233743721296 0.10166106923352 no 267 0.0881336966825011 143 7066794 SGTC_1325 1431-0015 227 µM 1.35230644519913 0.101666336690921 no 268 0.0881386517148863 105 1103340 SGTC_1575 cyproterone acetate 48 µM 1.35097896569801 0.101892144034978 no 269 0.0883510853931139 126 9880 An androgen receptor antagonist and liver toxin. SGTC_578 3460-0051 92 µM 1.34737980329375 0.102506205945053 no 270 0.0889289709413656 138 2876744 SGTC_1951 sophoraflavanone G 9.2 µM 1.34578923140077 0.102778432889887 no 271 0.0891852496436279 111 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_757 1066-0008 322 µM 1.3447557218181 0.102955599784704 no 272 0.0893520667658397 119 6842497 SGTC_3189 9110682 49.47 µM 1.34075974820074 0.103642687109247 no 273 0.0899992344100951 116 17122418 SGTC_1728 st035614 33.7865 µM 1.33874757255691 0.103989927294905 no 274 0.0903264317553562 141 15945546 SGTC_1120 ficusin 1.78878 µM 1.33668762731652 0.104346284162719 no 275 0.0906623111318206 111 6199 A DNA cross-linker. SGTC_2222 6885208 172.143 µM 1.33646814559025 0.10438430515238 no 276 0.0906981527673958 98 609514 SGTC_2842 9000675 19.48 µM 1.33362904140082 0.104877030470636 no 277 0.0911627301841382 118 2989072 SGTC_1981 st071826 47 µM 1.33131176820681 0.105280438640614 no 278 0.091543223791468 123 11838600 SGTC_2059 5238311 157 µM 1.32939336562406 0.10561525692883 no 279 0.0918591127451001 126 703021 SGTC_74 000s-0487 160.283 µM 1.32658622292885 0.106106573348868 no 280 0.0923227978558418 101 677548 SGTC_1839 st053978 48 µM 1.32170843292205 0.106964225616076 no 281 0.0931326297349309 108 3788398 SGTC_1669 st015249 58.4 µM 1.31928731046847 0.107391779132711 no 282 0.0935365392455584 100 722793 SGTC_409 arachidonic acid 100 µM 1.31726528133244 0.10774979845202 no 283 0.0938748592496694 118 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_14 0354-0009 295 µM 1.31596235986538 0.10798094801861 no 284 0.0940933382380347 125 1713507 SGTC_698 k064-0052 127 µM 1.31536658253489 0.108086762966124 no 285 0.09419336541992 131 5088751 SGTC_3008 9078912 71.4286 µM 1.31528819777607 0.108100690298237 no 286 0.094206531553582 122 16648731 SGTC_833 3852-0053 558 µM 1.31500177538313 0.108151592552127 no 287 0.0942546529024045 135 3123681 SGTC_624 k048-0052 28 µM 1.31318397732062 0.108475049238456 no 288 0.0945604808603376 109 6835531 SGTC_2265 7929201 200 µM 1.31132344173438 0.108806830706554 no 289 0.0948742559162383 135 1265108 SGTC_2170 morpholine 200 µM 1.30751301198454 0.109488604650853 no 290 0.0955192693277819 112 121171 Reacts with secondary amines. SGTC_2725 haloperidol 53.21 µM 1.30624289708883 0.109716537875161 no 291 0.0957349845591943 141 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_151 3013-0144 2.285 µM 1.30445741333606 0.11003753425887 no 292 0.0960388353356288 151 906558 YHR107C CDC12 SGTC_2774 tamoxifen 10.92 µM 1.29940868034642 0.110948846350401 no 293 0.0969018571545313 119 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_949 1165-0505 146 µM 1.29740567634188 0.11131188862718 no 294 0.0972458202310795 109 6244267 SGTC_2942 9052777 62.25 µM 1.29452459178692 0.111835572102537 no 295 0.0977421402763922 149 6469503 SGTC_368 fentichlor 4.58 µM 1.29389543512316 0.111950165475781 no 296 0.0978507707521582 127 7329 A pesticide. SGTC_3122 9126309 49.47 µM 1.28717333876913 0.113179758202085 no 297 0.0990169388935445 144 17591206 SGTC_2388 9080168 200 µM 1.28543729866849 0.113498870992597 no 298 0.0993197571636402 129 15943073 SGTC_1228 0124-0032 52.5 µM 1.28258408980417 0.114024730624397 no 299 0.0998189135831448 109 X1228 SGTC_1452 4194-0072 190 µM 1.28248351895854 0.114043297914194 no 300 0.0998365413866142 132 1343545 SGTC_2359 9039622 200 µM 1.27810587841396 0.114853581841786 no 301 0.100606048262823 122 6463596 SGTC_528 3492-0019 172 µM 1.27342806546422 0.115723943646396 no 302 0.101433091782258 146 2869262 SGTC_2234 tolnaftate 200 µM 1.26760251598975 0.116814391490219 no 303 0.102469966498928 121 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_43 0570-0105 72.5 µM 1.26684690640779 0.116956361167752 no 304 0.102605018117301 128 1114046 YDL195W SEC31 SGTC_805 3852-0218 479 µM 1.26641010388442 0.117038486703271 no 305 0.102683147701801 125 6615355 SGTC_1545 lovastatin 49.4 µM 1.26561964368728 0.117187209141584 no 306 0.102824644905643 152 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1609 st001574 46.4 µM 1.26438250471732 0.117420241340135 no 307 0.103046384646715 143 3960012 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.26306111869531 0.117669504842514 no 308 0.103283607873476 113 6857784 SGTC_1648 st011736 69.8 µM 1.26304629653804 0.117672302985843 no 309 0.103286271083862 125 2855514 SGTC_555 4296-0685 37 µM 1.26288257412967 0.11770321381732 no 310 0.103315691658489 141 2908540 YHR072W ERG7 SGTC_855 0428-0020 25 µM 1.26241938640509 0.117790694901373 no 311 0.103398958478255 123 6812414 SGTC_1690 st023502 41.2 µM 1.26134270126351 0.117994223431773 no 312 0.103592701354109 141 24207482 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.25923950691694 0.118392512920195 no 313 0.103971917871179 142 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1965 Pectolinarigenin 58.4 µM 1.25902449504289 0.118433283973345 no 314 0.104010742236617 124 5320438 An anti-inflammatory. SGTC_2464 5717415 7.67 µM 1.25566895734776 0.119070855153258 no 315 0.104618009288366 127 5285744 SGTC_1442 4112-3290 3 µM 1.25309118305153 0.119562289999886 no 316 0.10508626220731 122 704353 SGTC_719 2810-4230 27.3 µM 1.25254292657742 0.11966699555344 no 317 0.105186048356041 116 721079 SGTC_336 4111-0029 111 µM 1.24869320548109 0.120404033475009 no 318 0.105888653473711 123 3131175 SGTC_94 0334-0113 514.748 µM 1.24831521793653 0.120476572059521 no 319 0.105957821681427 127 6795178 SGTC_1822 st052468 42 µM 1.24504053208405 0.121106296763732 no 320 0.106558425836039 128 2873678 SGTC_1949 st076024 69.1 µM 1.24417030978113 0.121274029922097 no 321 0.106718444243752 147 2921930 SGTC_3245 9134821 49.47 µM 1.24196239104035 0.121700333583186 no 322 0.107125219243462 152 17014901 SGTC_3077 9117319 49.47 µM 1.24143735385101 0.121801862246149 no 323 0.1072221136006 144 17154678 SGTC_1439 4092-1168 46 µM 1.24065236578747 0.12195376968102 no 324 0.107367099112661 132 2886240 SGTC_995 3931-2021 34.6 µM 1.24025569327967 0.122030582588894 no 325 0.107440417350842 130 730143 SGTC_2135 5326629 150.42 µM 1.24018361594533 0.122044543516847 no 326 0.107453743506591 119 5020077 SGTC_3304 9125678 46.087 µM 1.23971732096668 0.122134889032456 no 327 0.107539984129044 148 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1819 st053448 58.6 µM 1.23958172021129 0.122161170741345 no 328 0.107565072663482 153 2857616 SGTC_999 SEC7.066 22.7 µM 1.23756330590662 0.122552842904979 no 329 0.107939013691856 152 740511 YDR170C SEC7 SGTC_526 4469-0568 170 µM 1.23728061717803 0.122607768756167 no 330 0.107991460595907 131 2901964 SGTC_3285 9112818 20.8695 µM 1.23684914276417 0.122691636658861 no 331 0.108071546905677 171 17017947 YPR165W RHO1 SGTC_488 nitrendipine 139 µM 1.23287054115795 0.123466874469624 no 332 0.108812033907014 121 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1226 3909-7979 35.4 µM 1.23198836002887 0.123639232810412 no 333 0.108976716131538 155 6615510 SGTC_1546 5-methoxyflavanone 78.7 µM 1.23125840918347 0.123781976107866 no 334 0.10911311597453 121 147795 SGTC_1502 4534-4282 27.7 µM 1.2306255672052 0.123905822914392 no 335 0.109231469146575 134 3278949 SGTC_129 0088-0017 176.636 µM 1.22445681762933 0.125117587535825 no 336 0.110389973399969 124 182446 SGTC_3349 9149703 23.001 µM 1.22411240129047 0.125185486409117 no 337 0.110454914212572 122 4910494 SGTC_2896 9052656 71.43 µM 1.22400091172485 0.125207471179595 no 338 0.110475941797053 184 6469436 SGTC_2244 6635614 200 µM 1.22352513241029 0.125301321013076 no 339 0.110565708815166 109 836499 SGTC_1181 1222-0449 220 µM 1.2232720875436 0.125351255371248 no 340 0.110613473005397 137 658318 SGTC_954 1189-0853 2.85 µM 1.22323287544212 0.125358994495393 no 341 0.110620875918315 135 2828194 SGTC_2023 5144124 124 µM 1.217657178575 0.126462843112551 no 342 0.11167713804129 131 2830192 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.21752534408845 0.126489024738176 no 343 0.111702199833742 127 4620898 SGTC_346 4513-0042 7.16 µM 1.2160998520763 0.126772361012014 no 344 0.111973443448049 147 2827372 SGTC_908 3448-7491 47.7 µM 1.2149867802567 0.126993906477491 no 345 0.112185566723118 132 1203031 SGTC_678 1218-2179 85.9 µM 1.21390184991208 0.127210109871591 no 346 0.11239260321319 149 6820081 YOR116C RPO31 SGTC_840 0245-0196 390 µM 1.21382900858029 0.127224634758066 no 347 0.112406513246007 132 3827528 SGTC_201 4262-0159 12.803 µM 1.21327967192655 0.127334212099401 no 348 0.112511456091213 126 1341029 SGTC_2203 7227154 166.4 µM 1.21136533574264 0.127716581686953 no 349 0.112877709260316 118 896304 SGTC_509 pifithrin 175 µM 1.20948548640689 0.128092838826523 no 350 0.113238191831544 144 4817 A p53 inhibitor. SGTC_927 2425-1185 123 µM 1.20536542822804 0.128920171137903 no 351 0.114031130784665 155 730375 SGTC_783 0848-0141 92.7 µM 1.20254851446254 0.129487953015806 no 352 0.114575540750241 160 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2528 xanthyletin 44.79 µM 1.20008013207442 0.12998690660071 no 353 0.115054110438431 147 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1476 4112-3294 3.34 µM 1.19985829738653 0.130031812882866 no 354 0.115097189232751 145 704369 SGTC_1838 st055369 84.5 µM 1.19694138359163 0.130623286476734 no 355 0.115664701263877 128 676036 SGTC_2197 6588183 93.1375 µM 1.19465050198698 0.131089119449745 no 356 0.116111804533009 134 884136 SGTC_852 0418-0143 439 µM 1.1945478770125 0.131110014263885 no 357 0.116131862153868 142 5369229 SGTC_2855 9016525 58.44 µM 1.19183423512607 0.1316633563683 no 358 0.116663124537259 153 43811474 SGTC_1242 0402-0103 60.1 µM 1.19064852117678 0.131905641999795 no 359 0.116895797492464 137 432868 SGTC_1957 st077035 62.4 µM 1.18969910802775 0.132099864138377 no 360 0.117082338050315 143 705593 SGTC_2705 st078069 42.8 µM 1.18921310805018 0.132199361777065 no 361 0.117177908831017 140 1530061 SGTC_2781 5567276 71.43 µM 1.18779138658268 0.132490724077218 no 362 0.117457804360066 151 2853274 SGTC_681 1642-0006 26.6 µM 1.18731846282839 0.13258774130732 no 363 0.117551014107324 160 4446530 SGTC_2987 9018338 71.43 µM 1.18669413696837 0.132715892630071 no 364 0.117674144258929 169 5055682 SGTC_2673 kobusone 100 µM 1.18320792532625 0.133433052759516 no 365 0.118363376397031 155 6710676 An epoxy ketone and protein crosslinker. SGTC_2512 diallyl trisulfide 49.23 µM 1.17923085271561 0.134254439204405 no 366 0.119153131899872 166 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2484 5809818 12.04 µM 1.17844676785655 0.134416785513652 no 367 0.119309271153347 139 2870548 SGTC_2117 5521686 200 µM 1.17520421745589 0.135089592932802 no 368 0.11995651167544 144 803312 SGTC_1164 k060-0068 93.7 µM 1.17503242698923 0.135125302603099 no 369 0.119990871412642 143 5963676 SGTC_651 3253-0966 34.4 µM 1.1747675649285 0.135180371523141 no 370 0.12004385995099 148 781462 SGTC_2656 pseudo-anisatin 100 µM 1.17235420109999 0.135682856077317 no 371 0.120527439494799 153 6708809 A neurotoxin. SGTC_1770 st043884 66.3 µM 1.16956950533247 0.136264243412364 no 372 0.121087127593855 176 670149 SGTC_3239 9133757 49.47 µM 1.16856427667886 0.136474532651338 no 373 0.121289614069031 140 17036923 SGTC_2540 epiandrosterone 100 µM 1.16720788779626 0.136758634674557 no 374 0.121563213131232 150 441302 A steroid. SGTC_2020 4017018 200 µM 1.16708047971673 0.13678534165286 no 375 0.121588935059136 140 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1262 0737-0114 49.6 µM 1.1667336334141 0.136858064812434 no 376 0.121658977907845 161 765919 SGTC_815 1582-0027 36.9 µM 1.16576552411956 0.137061187800799 no 377 0.121854629880146 158 3128206 SGTC_1816 st051957 91.6 µM 1.16472737051056 0.137279235842231 no 378 0.122064683090172 132 674121 SGTC_3320 9137005 35.139 µM 1.16019279640337 0.138234429281305 no 379 0.122985159608536 167 4908713 SGTC_1818 st052136 56.3 µM 1.1601877373899 0.138235497470422 no 380 0.122986189251635 159 674169 SGTC_2865 9030313 51.95 µM 1.15923889605477 0.138435940781407 no 381 0.123179410439582 121 42562754 SGTC_2495 cafestol 54.53 µM 1.15872701418208 0.13854415835254 no 382 0.123283737899591 176 16667697 An anti-infammatory. SGTC_626 0214-0009 33 µM 1.15715189993282 0.138877516676983 no 383 0.123605152762583 156 3437874 SGTC_1594 piperine 70.1 µM 1.15699247174974 0.138911288587663 no 384 0.123637718052788 143 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_843 0310-0051 143 µM 1.14976555745625 0.140448050314443 no 385 0.125120222368372 157 2065037 SGTC_98 0074-0023 107.663 µM 1.14958412387871 0.140486779075488 no 386 0.125157600094553 124 3563821 SGTC_3275 9138069 49.47 µM 1.14923597586685 0.140561114956021 no 387 0.125229345043043 168 17617007 SGTC_95 0471-0001 561.058 µM 1.14846146792514 0.140726582126147 no 388 0.125389055526167 160 4015405 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.14575859277173 0.141305064126228 no 389 0.125947526256296 168 688801 SGTC_3072 9116419 49.47 µM 1.14356564463706 0.141775592009005 no 390 0.126401908115326 146 17170162 SGTC_1375 2910-0797 186 µM 1.14328499366623 0.141835886126591 no 391 0.126460141717099 136 742508 SGTC_373 0844-0104 25.9 µM 1.14073460811031 0.142384598286949 no 392 0.126990190042132 167 5375804 SGTC_472 calcifediol 10 µM 1.13996598782032 0.142550247181619 no 393 0.12715023570214 126 5283731 A vitamin D metabolite. SGTC_3046 9092212 49.47 µM 1.13819025966921 0.142933440710997 no 394 0.127520522510707 156 25236637 SGTC_3210 9128157 49.47 µM 1.13793137704661 0.14298936441273 no 395 0.127574569023233 152 17590849 SGTC_3099 9120367 49.47 µM 1.13585348776053 0.143438764627308 no 396 0.128008943585745 164 24824940 SGTC_914 3820-6779 408 µM 1.13545233312912 0.143525634954873 no 397 0.128092921569783 126 2893481 SGTC_2242 6630449 61.2675 µM 1.13524011318227 0.143571605699481 no 398 0.128137363311925 140 691249 YDR170C SEC7 SGTC_272 doxorubicin 8.13 µM 1.13485981973075 0.143654009116767 no 399 0.128217028718884 166 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1389 3405-0187 19 µM 1.1343233566898 0.143770306210137 no 400 0.12832946763482 145 799890 SGTC_2903 5923464 63.88 µM 1.132627203242 0.144138424536698 no 401 0.128685419917459 156 2876576 SGTC_2368 9071271 200 µM 1.13051805716937 0.144597060920796 no 402 0.12912899702573 151 27209959 SGTC_2561 acetosyringone 100 µM 1.13019401189464 0.144667611989682 no 403 0.129197241217519 170 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_982 1491-0518 27.5 µM 1.12537092561306 0.145720434182506 no 404 0.130215943059163 135 3091256 SGTC_463 ikarugamyin 104 µM 1.12510066342309 0.145779581203286 no 405 0.130273190116034 122 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2113 5491891 107.031 µM 1.12380386564577 0.146063610528876 no 406 0.130548120603858 158 789979 SGTC_1848 st056003 16.4 µM 1.12260401023232 0.146326738094056 no 407 0.130802855728677 153 146492 SGTC_2236 dapsone 200 µM 1.12239923534918 0.14637167687752 no 408 0.130846364726595 132 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1080 nisoldipine 24.4 µM 1.12207260528886 0.146443376512402 no 409 0.13091578527804 168 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_554 4483-2211 187 µM 1.12129870628268 0.146613351718146 no 410 0.131080368030821 146 747107 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.12024469568913 0.146845062072054 no 411 0.131304751085222 154 364106 SGTC_1023 4482-3888 16 µM 1.1189696401526 0.147125694403923 no 412 0.131576545619847 174 3303168 SGTC_1481 3346-2004 36 µM 1.1187513207529 0.147173781268329 no 413 0.131623122123788 172 2770522 SGTC_2857 9024691 58.44 µM 1.11647303930486 0.147676222454948 no 414 0.132109852201913 158 16478292 SGTC_3070 9117005 49.47 µM 1.11584146936667 0.147815708974749 no 415 0.132244999684758 118 8779016 SGTC_577 r071-0003 38.6 µM 1.11244846378747 0.148566587007649 no 416 0.132972688487749 174 4568517 YMR134W ERG29 SGTC_963 1269-2853 151 µM 1.10848946226493 0.149445939465812 no 417 0.133825243802006 145 3668223 SGTC_1025 k007-0731 70 µM 1.10650196301417 0.149888699470158 no 418 0.134254657419112 145 6256118 SGTC_3050 9093513 49.47 µM 1.10603094887984 0.149993756524399 no 419 0.134356561994078 181 25236664 SGTC_3321 9137793 26.8275 µM 1.10535304829665 0.150145044601448 no 420 0.134503319956832 173 4904192 SGTC_2895 9054447 58.44 µM 1.10292083739805 0.150688681626463 no 421 0.135030772177347 162 2697450 SGTC_1030 k029-0042 36.7 µM 1.09820008758447 0.151747579326467 no 422 0.13605856400365 152 6080581 SGTC_2111 5486399 200 µM 1.09704715108507 0.152006940656913 no 423 0.136310390443073 161 689674 SGTC_3115 9123671 49.47 µM 1.09327373348517 0.152857855707454 no 424 0.137136815950361 173 3286988 SGTC_1747 st037496 66.6 µM 1.09299726332226 0.152920324368307 no 425 0.137197500659874 189 723305 SGTC_3273 9137859 49.47 µM 1.0916983444678 0.153214042704238 no 426 0.137482856557571 194 2377234 SGTC_1829 berberine 14.4 µM 1.09082090262776 0.153412665877629 no 427 0.137675848485516 181 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2110 5483698 200 µM 1.09050129765693 0.153485055999505 no 428 0.137746191003025 153 2848765 YHR062C RPP1 SGTC_695 3505-6186 243 µM 1.08775113658362 0.154108898798176 no 429 0.138352493073569 178 1819379 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.08686599568685 0.154310039264394 no 430 0.138548018093707 158 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1006 4099-6547 255 µM 1.08583854896724 0.154543735084181 no 431 0.138775214060648 171 3146833 SGTC_2681 menadione 3.18 µM 1.08426090675971 0.154903029648714 no 432 0.139124566674487 181 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_792 4534-1957 155 µM 1.08389782627162 0.154985796170771 no 433 0.139205051766209 149 1717904 SGTC_1124 fisetin 1.16336 µM 1.08271551333973 0.155255514328394 no 434 0.139467358016978 162 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1740 st038286 13.222 µM 1.08119859395923 0.155602018914832 no 435 0.139804391669366 159 716786 SGTC_2680 butyl paraben 22.24 µM 1.07959262991128 0.155969419133415 no 436 0.140161812417421 188 7184 An antifungal and steroid mimetic. SGTC_3325 9138760 55.175 µM 1.07810823356002 0.156309516113859 no 437 0.140492728834113 143 43844959 SGTC_1125 tnp00248 1.32998 µM 1.07701605068829 0.156560062931342 no 438 0.140736547553779 184 24207736 SGTC_60 0986-0278 202 µM 1.07656885406103 0.156662726116505 no 439 0.140836462456936 161 3110598 SGTC_2031 5180455 200 µM 1.07625080937063 0.156735766776237 no 440 0.14090755086691 167 29949 SGTC_1189 1431-2119 7.28 µM 1.06947069169588 0.158298187933479 no 441 0.142428814183535 176 3107275 SGTC_1386 3228-0095 33.8 µM 1.0690952575839 0.158385001154293 no 442 0.142513374189837 157 870181 SGTC_2467 5474540 200 µM 1.06723627625718 0.158815321411689 no 443 0.1429325776458 167 5413519 SGTC_1290 0986-0249 10.2 µM 1.0668792953317 0.158898043610965 no 444 0.143013172730092 164 53329 SGTC_123 0083-0120 66.675 µM 1.06628668559522 0.159035429757435 no 445 0.143147033187691 196 16001701 SGTC_2304 7443016 91.4 µM 1.06497325054241 0.159340203896572 no 446 0.143444017413048 153 939854 SGTC_707 0865-0008 204 µM 1.06471871438771 0.159399311581151 no 447 0.143501619331382 181 723043 SGTC_3175 9106517 49.47 µM 1.06442792553718 0.159466855332673 no 448 0.143567444396505 169 41468073 SGTC_721 1187-1332 279 µM 1.06078627381176 0.160314315965414 no 449 0.144393520779364 167 25730 SGTC_1431 4049-0260 9.09 µM 1.06053283960693 0.160373402811461 no 450 0.144451129062502 185 3854841 SGTC_1899 st063254 59.6 µM 1.06008734996791 0.160477300856703 no 451 0.144552431118676 155 3093813 SGTC_825 1988-2224 89.6 µM 1.05791604418837 0.1609843267919 no 452 0.145046859940365 180 1180859 SGTC_419 nsc-638432 893 µM 1.05669227126854 0.161270552648233 no 453 0.145326026713392 169 368090 SGTC_1876 myriocin 605 nM 1.05568491185148 0.161506410915761 no 454 0.145556096354122 181 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1840 st055363 71 µM 1.05393196998275 0.161917372177327 no 455 0.145957032341083 169 676033 SGTC_706 4262-0057 46.9 µM 1.05389904604499 0.161925097406977 no 456 0.145964569855709 168 883298 SGTC_1130 3454-2858 15.9 µM 1.05236479700961 0.162285357889486 no 457 0.146316106644471 205 715628 YIL048W NEO1 SGTC_2853 9015042 58.44 µM 1.05160307937958 0.162464412216138 no 458 0.146490847192131 144 6457456 SGTC_2728 chlorpromazine 9.18 µM 1.04973185219033 0.162904820741055 no 459 0.146920707446347 185 2726 A thorazine and dopamine antagonist. SGTC_401 neomycin 50 µM 1.04652010312152 0.163662539819822 no 460 0.147660484177207 163 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2677 mitomycin C 100 µM 1.04379029326796 0.164308355246799 no 461 0.148291211753708 184 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_980 1473-0395 201 µM 1.04331210761968 0.16442165372787 no 462 0.148401882656338 194 768876 SGTC_794 k038-0031 316 µM 1.04220797320672 0.164683454232406 no 463 0.148657633624547 162 6624242 SGTC_3337 9144342 33.5465 µM 1.0411443717981 0.164935899231958 no 464 0.148904274376012 175 17682949 SGTC_2731 amoxapine 43.43 µM 1.03876722751426 0.1655010180702 no 465 0.14945650326752 196 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2964 9083345 53.42 µM 1.0380240734945 0.165677944853582 no 466 0.149629423779876 187 17741579 SGTC_2152 5568786 200 µM 1.03740210920166 0.165826113305012 no 467 0.149774247882711 180 5399883 SGTC_3019 9081971 49.47 µM 1.03736478167453 0.165835008439452 no 468 0.149782942553698 165 16451803 SGTC_3112 9123419 49.47 µM 1.03584630384049 0.166197122551821 no 469 0.150136925817783 202 17015854 SGTC_1801 st050089 28.441 µM 1.035813953242 0.166204842809078 no 470 0.150144473359881 181 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_3078 9116413 49.47 µM 1.03533802307694 0.166318447179507 no 471 0.15025553926726 192 17177322 SGTC_3191 9110352 49.47 µM 1.03517964655865 0.166356262718632 no 472 0.150292511097012 165 17122424 SGTC_1724 st037281 8.293 µM 1.03418855785189 0.166593030899697 no 473 0.150524011107008 178 574124 YDL195W SEC31 SGTC_1761 st044296 37 µM 1.03380387169665 0.166684989857632 no 474 0.15061393064083 181 1826700 SGTC_1109 tnp00067 928.257 nM 1.03191800312398 0.167136279234142 no 475 0.151055265715609 155 676295 SGTC_3005 9076496 71.4286 µM 1.03117698992965 0.167313819469756 no 476 0.151228914500329 177 21368410 SGTC_136 0097-0015 404.482 µM 1.03068412130591 0.167431973734107 no 477 0.151344486674271 185 4861337 SGTC_69 0096-0274 206.684 µM 1.0303824564788 0.167504317667674 no 478 0.151415252669666 235 6741392 SGTC_3185 9108267 49.47 µM 1.03031576692221 0.16752031358183 no 479 0.151430899997995 177 4910486 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.02716604218834 0.168276915766021 no 480 0.152171142552221 156 115019 SGTC_1443 4112-3303 14 µM 1.02545853137503 0.168687997982871 no 481 0.152573441290439 188 704433 SGTC_947 3447-0010 211 µM 1.02485758972722 0.168832827747013 no 482 0.152715194102559 191 748350 SGTC_1301 naphtanilide LB 4.81 µM 1.02428782014031 0.168970218661106 no 483 0.152849674561155 192 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1667 st014849 34.6 µM 1.02289014675512 0.169307549533604 no 484 0.153179894374122 184 5348460 SGTC_1578 josamycin 24.2 µM 1.02212119185865 0.169493322328798 no 485 0.153361772142955 172 5282165 A P450 substrate. SGTC_1149 3909-7961 23.3 µM 1.02171524403345 0.169591448513485 no 486 0.153457847003698 162 735261 SGTC_2591 skatole 100 µM 1.02119627212989 0.169716948077862 no 487 0.153580729094028 176 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_3092 9117248 49.47 µM 1.0207317884657 0.169829321608468 no 488 0.153690764708425 198 17141857 SGTC_2440 5628896 157.78 µM 1.01977592415781 0.170060725994121 no 489 0.153917371986872 172 5522048 SGTC_2674 ligustilide 100 µM 1.01924767891324 0.170188695098836 no 490 0.154042698190196 173 5319022 A signalling regulator. SGTC_1534 6-azauridine 81.6 µM 1.01774122208179 0.170553977884177 no 491 0.154400475839022 196 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2775 cyproheptadine 69.59 µM 1.01547357898155 0.17110477746472 no 492 0.154940067386514 175 2913 A selective serotonin reuptake inhibitor. SGTC_2952 9073731 13.78 µM 1.01292529651347 0.171725098960875 no 493 0.155547922220802 182 16457353 SGTC_3155 9099265 49.47 µM 1.00976141983667 0.172497269178721 no 494 0.156304804047148 179 25236499 SGTC_217 ketoconazole 989 nM 1.0093559973037 0.17259637570337 no 495 0.156401966746708 181 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_461 N-acetylfarnesylcysteine 136 µM 1.0088316060903 0.172724618250497 no 496 0.156527700212166 191 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_709 3807-1509 243 µM 1.00759092918095 0.173028273905783 no 497 0.156825442674366 204 1886677 YPL242C IQG1 SGTC_2984 9022109 38.96 µM 1.0062319738157 0.173361268222696 no 498 0.157151997450433 208 6459207 SGTC_2134 5324836 1.464 µM 1.00609853393959 0.173393987909638 no 499 0.157184086929385 177 699272 SGTC_172 1112-0046 2.638 µM 1.0050762689459 0.173644779444419 no 500 0.157430063055471 161 2802135 YIL048W NEO1 SGTC_2818 7996756 12.99 µM 1.00439878835045 0.17381111236409 no 501 0.157593216906533 207 2241621 SGTC_3222 9128301 49.47 µM 1.00337875149576 0.174061739710426 no 502 0.15783907614569 188 4911358 SGTC_2424 5537928 59.2 µM 1.00024316922251 0.174833603146152 no 503 0.158596421252524 191 5382802 SGTC_244 nsc-207895 1.295 µM 0.997207084034977 0.175583040885924 no 504 0.159332001561557 142 42640 SGTC_741 4582-0002 126 µM 0.996751212861572 0.175695745233608 no 505 0.15944264226117 194 2912688 SGTC_177 1327-0068 8.361 µM 0.996116279920333 0.175852795110793 no 506 0.159596825344668 192 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2189 6047310 154.431 µM 0.995174784741508 0.17608583639371 no 507 0.159825631618745 166 711535 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.99415031337512 0.176339638155743 no 508 0.160074846796631 188 688664 SGTC_2614 arthonioic acid 13.39 µM 0.991154883240251 0.177083050704176 no 509 0.16080497854038 169 6710684 SGTC_1464 k208-0027 110 µM 0.990472399087708 0.177252707699262 no 510 0.160971636728595 194 X1464 SGTC_1934 st074720 32.6 µM 0.990381219183711 0.177275381649688 no 511 0.1609939108016 175 17250992 SGTC_2757 clomiphene 4.22 µM 0.98728707161462 0.178045897059167 no 512 0.16175096337419 211 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1286 0929-0070 131 µM 0.985751562788944 0.178429057557904 no 513 0.162127519975029 191 1420408 SGTC_990 3985-0011 41.3 µM 0.984490891410565 0.178744024994896 no 514 0.162437103908786 191 5399565 YGL099W LSG1 SGTC_890 0929-0006 47.2 µM 0.984242246015093 0.178806188119366 no 515 0.162498209322279 171 1378169 SGTC_903 1134-0042 114 µM 0.983216952129425 0.179062662644704 no 516 0.16275033661039 192 701009 SGTC_3356 9151811 4.48 µM 0.982314688317699 0.179288552884053 no 517 0.162972420255001 214 1859254 YPR165W RHO1 SGTC_2872 9044037 25.97 µM 0.97967314246739 0.179950918492983 no 518 0.163623743789116 179 6465195 SGTC_668 1682-0499 62.6 µM 0.97902949805196 0.180112544382843 no 519 0.163782702324666 186 682214 SGTC_2923 7992654 58.14 µM 0.978987336306358 0.180123134820431 no 520 0.163793118355377 181 2985126 SGTC_1780 st038448 24.544 µM 0.978717742322919 0.180190862278817 no 521 0.163859731530455 184 728868 YDL195W SEC31 SGTC_1857 st056007 79.3 µM 0.978324081145307 0.180289786630719 no 522 0.163957031673875 171 619834 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.975257199552348 0.181061639526928 no 523 0.164716347673735 189 688761 SGTC_301 4119-0100 24.5 µM 0.975050747265105 0.181113672368981 no 524 0.164767544019717 194 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1605 st000082 49.1 µM 0.972536407632355 0.181748121124151 no 525 0.165391880818259 194 1114022 SGTC_256 clotrimazole 625 nM 0.971071518802719 0.182118399915549 no 526 0.165756332734141 170 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_3158 9100007 49.47 µM 0.97025001434331 0.182326257183511 no 527 0.165960943131278 168 19297233 SGTC_2195 6536160 144.242 µM 0.969931041781193 0.182407003639205 no 528 0.166040432933313 167 3834386 SGTC_1224 0823-0416 294 µM 0.969020937798318 0.182637515114883 no 529 0.166267371302039 179 3598164 SGTC_1847 st056231 15 µM 0.968009606546917 0.182893878742475 no 530 0.166519785999696 188 5393180 SGTC_2408 sulbentine 18.36 µM 0.967497880959602 0.18302368222986 no 531 0.166647600031496 183 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1234 0326-0494 15.5 µM 0.966439311702048 0.183292379579913 no 532 0.166912200454136 212 1547813 SGTC_47 0149-0135 24.25 µM 0.966054287407098 0.183390171531975 no 533 0.167008508461315 205 5239155 SGTC_531 3788-1495 174 µM 0.965249787549688 0.183594610647999 no 534 0.167209857583053 182 2896655 SGTC_2165 5727197 32.143 µM 0.965076710502006 0.183638611460901 no 535 0.167253195514902 199 1361712 SGTC_2560 caryophyllene 100 µM 0.964784667945438 0.183712871383545 no 536 0.167326338438341 202 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2349 9023730 187.07 µM 0.964510666185664 0.183782560941431 no 537 0.167394981731733 177 4126287 SGTC_1806 st050005 60.3 µM 0.964431265625208 0.183802758742617 no 538 0.167414876658674 191 5194765 SGTC_1182 1222-0449 220 µM 0.964042314067846 0.183901719659352 no 539 0.16751235595183 192 658318 SGTC_1264 0783-0040 158 µM 0.963630942774426 0.18400642092668 no 540 0.167615493873738 185 2855798 SGTC_344 k064-0035 6.43 µM 0.961670032295205 0.184506017273412 no 541 0.168107690187713 192 5088750 SGTC_2178 5812956 200 µM 0.961627562201707 0.184516847033832 no 542 0.168118360628849 206 5403383 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.96008243254761 0.184911119776834 no 543 0.168506864603489 189 5355888 SGTC_1021 4476-0760 85.3 µM 0.958049292841255 0.185430715695065 no 544 0.169018951494204 167 746768 SGTC_2710 st078562 53.7235 µM 0.957871367286198 0.185476230026888 no 545 0.169063813116972 196 17250908 SGTC_1633 st005664 67.9 µM 0.957537232607538 0.185561722244373 no 546 0.169148081508675 182 2063822 SGTC_2961 9083290 32.55 µM 0.957410528371149 0.185594147380685 no 547 0.16918004322667 191 17741490 SGTC_2266 7929956 200 µM 0.957226825789708 0.185641165321952 no 548 0.169226389921779 197 2967153 SGTC_644 1498-1197 63.3 µM 0.953737750510208 0.186535582940433 no 549 0.170108203118389 198 6741615 SGTC_1299 1079-1439 3.74 µM 0.952420181518405 0.186874032171398 no 550 0.1704419641782 199 323161 SGTC_1711 st032263 62.8 µM 0.952269869428026 0.186912667575631 no 551 0.17048006724141 203 3958979 SGTC_2521 angolensin 13.4 µM 0.951630504342949 0.187077061727357 no 552 0.17064220275925 187 821428 A flavenoid. SGTC_1718 roemerine 11.9335 µM 0.951352642366247 0.187148533731548 no 553 0.170712696072876 201 235224 An aporphine alkaloid with mutagenic activity. SGTC_782 0083-0095 30.5 µM 0.950339667121769 0.187409235462845 no 554 0.170969844723253 181 3591729 An indicator and reagent. SGTC_2394 5221648 200 µM 0.948438935765114 0.187899017643923 no 555 0.171453022882199 211 788586 SGTC_2162 5663267 200 µM 0.945800177121807 0.188580284265219 no 556 0.172125257615146 200 6456493 SGTC_1784 st039334 36.3 µM 0.944479111898904 0.188921924183602 no 557 0.172462435507786 214 3496984 SGTC_308 4092-1169 104 µM 0.94147325536328 0.189700686743114 no 558 0.173231194277492 207 2268590 YDL196W YDL196W SGTC_377 3970-0964 33.1 µM 0.939761335886346 0.190145095010165 no 559 0.17366999769883 195 16481235 SGTC_3288 9119690 36.221 µM 0.939593971518506 0.190188576512986 no 560 0.173712934860881 208 17595618 YKL019W RAM2 SGTC_1909 st060837 51.5 µM 0.939131005330571 0.190308887612745 no 561 0.173831743550194 201 678937 SGTC_2801 7907800 81.82 µM 0.938742462201374 0.190409894452342 no 562 0.173931493300179 217 6620925 SGTC_3332 9141069 11.198 µM 0.937779528079572 0.190660363568957 no 563 0.174178861920674 195 17332883 SGTC_1289 0976-0073 69.1 µM 0.934348149917102 0.191554543584884 no 564 0.175062167232039 201 3391136 SGTC_1093 fluphenazine 7.97 µM 0.931748975698956 0.192233567254346 no 565 0.175733134721716 213 6602611 An atypical antipsychotic. SGTC_343 4130-2827 29.8 µM 0.930633563690641 0.192525415028251 no 566 0.176021573252783 175 1118244 SGTC_3135 9127742 49.47 µM 0.930376879929417 0.192592614702797 no 567 0.176087992461905 210 3643468 SGTC_888 0916-0002 6.97 µM 0.929441075305262 0.192837729248394 no 568 0.176330274580951 176 2802138 YIL048W NEO1 SGTC_347 4534-1311 26.2 µM 0.929153700394746 0.192913039355327 no 569 0.176404718964757 189 2862016 SGTC_1616 st002734 56.1 µM 0.929055348126056 0.19293881789467 no 570 0.176430201656596 208 4026101 SGTC_2733 amorolfine 100 µM 0.928580360412327 0.193063343765467 no 571 0.176553301911041 226 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_830 4076-0286 57.8 µM 0.928046551806701 0.193203349053595 no 572 0.17669171130095 201 6866659 SGTC_1696 st025591 34.7925 µM 0.92688814346948 0.193507385071489 no 573 0.176992306900193 182 2787147 SGTC_2334 9017922 200 µM 0.925790843359402 0.193795651609907 no 574 0.177277343338972 189 3163164 SGTC_2575 plumbagin 510 nM 0.925094914533566 0.193978611377066 no 575 0.177458269065464 199 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1249 0481-0015 10.2 µM 0.924356299603332 0.194172908417744 no 576 0.177650419668577 215 4227577 SGTC_2900 5328528 85.29 µM 0.923497546748407 0.194398957420042 no 577 0.177873989129 214 795359 SGTC_2727 riluzole 51.77 µM 0.919597963677771 0.195427456368993 no 578 0.178891445624509 220 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_689 0833-0039 98 µM 0.919557298443156 0.195438199040348 no 579 0.178902075021866 226 5374726 SGTC_931 2812-0076 566 µM 0.916539963099597 0.196236298990299 no 580 0.179691878495726 194 3450959 SGTC_508 roscovitine 141 µM 0.915685152156066 0.196462759376839 no 581 0.179916027421599 224 160355 A CDKinase inhibitor. SGTC_2216 7189485 200 µM 0.915588852724494 0.196488281380571 no 582 0.1799412901045 188 731273 SGTC_1731 st035964 63 µM 0.915162208718371 0.19660137796851 no 583 0.180053240428885 206 6739575 SGTC_1016 4226-1401 38 µM 0.914380549944777 0.19680868565327 no 584 0.180258459165636 215 2901613 SGTC_254 nsc-64875 3.808 µM 0.912239546133317 0.197377189583731 no 585 0.180821315198972 178 56993 SGTC_771 0250-0039 27.3 µM 0.911890645967726 0.197469927585339 no 586 0.180913143075648 228 3005115 SGTC_1480 1070-0044 41.2 µM 0.9116572733444 0.197531972957083 no 587 0.180974581288919 198 3124987 SGTC_3318 9139014 38.6185 µM 0.909221920852731 0.198180148424081 no 588 0.18161649769076 233 16643984 SGTC_776 4476-4378 112 µM 0.908197265601635 0.198453246439745 no 589 0.181887004262117 210 2892008 SGTC_2132 5317594 122.667 µM 0.906492952366013 0.198907994080556 no 590 0.182337496742964 231 794577 SGTC_2202 7226349 200 µM 0.90537934009958 0.199205468895203 no 591 0.182632228490317 179 844334 SGTC_2404 5161160 200 µM 0.90427263912489 0.199501362837812 no 592 0.18292542562453 232 2831543 SGTC_2095 5432005 200 µM 0.903758401496368 0.199638942343991 no 593 0.183061761962389 222 783734 SGTC_597 k018-0003 82.8 µM 0.903738397158177 0.19964429547244 no 594 0.183067066857721 228 6786234 SGTC_1564 D-Arginine 115 µM 0.903492873069343 0.199710004355527 no 595 0.183132184526504 225 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1768 st044301 37.178 µM 0.89983319639819 0.200690974351816 no 596 0.184104512656325 255 3931349 SGTC_690 glyoxal 20.3 µM 0.899503846095943 0.200779397776113 no 597 0.184192174057115 217 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2082 5219693 150 µM 0.898291718402947 0.201105029145284 no 598 0.184515023263822 202 2834649 SGTC_445 e6 berbamine 66 µM 0.896663586427332 0.201542915854328 no 599 0.184949228356563 236 6610268 A calcium/calmodulin antagonist. SGTC_300 r073-0011 5.04 µM 0.896418481304108 0.201608886407825 no 600 0.185014650170318 199 2735780 SGTC_510 ag-490 170 µM 0.896364141857862 0.201623513734427 no 601 0.18502915603732 197 5328779 SGTC_926 2268-1401 59.4 µM 0.895154159889227 0.201949386559202 no 602 0.185352342668891 232 2931578 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.89444974455226 0.202139245091209 no 603 0.185540653573592 205 6708784 An antioxidant flavonoid SGTC_750 4073-0104 132 µM 0.89387738738454 0.202293589074263 no 604 0.185693748848332 184 22330957 SGTC_209 4077-0173 175.592 µM 0.8934366261571 0.20241249443031 no 605 0.185811697967353 197 15993494 SGTC_693 4161-2696 114 µM 0.891572137496708 0.202915944742843 no 606 0.186311154972843 241 805759 SGTC_1355 1499-0035 1.68 µM 0.890012925475375 0.203337537787476 no 607 0.186729472859087 211 1548538 SGTC_101 0490-5701 117.494 µM 0.889148830833478 0.203571403991578 no 608 0.186961549274207 190 4661669 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.88910763524062 0.203582557535378 no 609 0.186972617940284 215 1377 SGTC_1265 0819-1001 68.8 µM 0.889074993303273 0.203591395469573 no 610 0.186981388649466 220 3106768 SGTC_711 k292-0785 179 µM 0.888990849006166 0.203614178927364 no 611 0.187003998933467 216 4146315 SGTC_3279 9140807 49.47 µM 0.888496509951064 0.203748060090801 no 612 0.187136866172758 219 45595718 SGTC_2291 7917025 104.35 µM 0.888344837507038 0.203789147847939 no 613 0.187177644022759 200 2964612 SGTC_2465 5809242 33.21 µM 0.888083359320058 0.203859993353913 no 614 0.187247956564702 239 2731748 SGTC_2120 5538279 151.968 µM 0.888074225646726 0.203862468317832 no 615 0.18725041294157 181 2058197 SGTC_1180 1193-0155 285 µM 0.887379686746622 0.204050720922418 no 616 0.187437258065692 209 2921347 SGTC_2734 clemastine 41.6 µM 0.887050954757133 0.204139858800691 no 617 0.187525733837559 239 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2651 TUB2.036 5 µM 0.886748148409377 0.204221987285608 no 618 0.18760725474689 219 15992207 YFL037W TUB2 SGTC_428 3448-4153 16.5 µM 0.886419845806509 0.204311053205999 no 619 0.187695664441103 197 3834874 SGTC_471 1-acyl-paf 4 µM 0.886415470598608 0.204312240321713 no 620 0.187696842829068 193 16759367 SGTC_2267 7931562 200 µM 0.884157065672736 0.204925556464415 no 621 0.188305715757986 188 934880 SGTC_1661 st013063 9.66 µM 0.883339442996294 0.205147868260602 no 622 0.188526449442323 226 721395 SGTC_2319 6033012 152.6 µM 0.883299435425071 0.205158750005198 no 623 0.188537254383736 214 847246 SGTC_1719 st032227 49.2 µM 0.882678141409945 0.205327781106794 no 624 0.188705097764498 215 3125804 SGTC_2418 pentamidine 31.67 µM 0.882194041991004 0.205459543959514 no 625 0.188835941667599 222 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2712 st079126 47.7 µM 0.882159048780437 0.205469070405724 no 626 0.188845401908018 214 3152970 SGTC_2099 5377090 177.372 µM 0.881163239845206 0.205740276349594 no 627 0.189114736293944 216 2243829 SGTC_1743 st037606 46.3785 µM 0.880250724615452 0.205988983899411 no 628 0.189361750003705 177 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2558 carylophyllene oxide 100 µM 0.879852548714211 0.206097563261804 no 629 0.189469596608796 223 6708694 An oxygenated terpenoid and antifungal agent. SGTC_3267 9137951 49.47 µM 0.878522441973335 0.206460518610412 no 630 0.189830132170862 217 16643986 SGTC_703 3875-0075 71.8 µM 0.878489927902049 0.206469395687107 no 631 0.189838950636285 244 2850814 SGTC_620 0109-0052 432 µM 0.877104408657653 0.206847883855241 no 632 0.190214965159488 235 493037 SGTC_3036 9090181 49.47 µM 0.875558310525047 0.207270722514766 no 633 0.190635098786438 225 25236586 SGTC_583 1488-1091 88.9 µM 0.87467870241768 0.207511512370436 no 634 0.190874375752503 245 4303273 SGTC_2824 7998404 51.95 µM 0.872633596726077 0.208071992036437 no 635 0.191431411068452 212 837851 SGTC_2470 5664817 21.68 µM 0.872497424157391 0.208109343059186 no 636 0.191468536385994 215 2859561 SGTC_2655 perillic acid 100 µM 0.872290207979438 0.208166188355337 no 637 0.191525039094065 223 5702197 An apoptosis inducer. SGTC_677 0929-0063 136 µM 0.872277847301552 0.208169579530705 no 638 0.191528409866914 236 1539583 SGTC_1425 4048-4433 7.33 µM 0.8718040368088 0.208299594910106 no 639 0.19165764599736 253 23734946 SGTC_235 0330-0087 5 mM 0.87148985962132 0.208385832718543 no 640 0.191743370130204 210 46494818 YHR062C RPP1 SGTC_2274 7947094 46.08 µM 0.869787871607117 0.208853373593838 no 641 0.192208170354152 220 2971028 SGTC_2529 gangaleoidin 93.61 µM 0.869686922556587 0.20888112398306 no 642 0.192235760421689 219 4565183 SGTC_1628 st004252 77.7 µM 0.868781043759432 0.209130242727988 no 643 0.192483451698424 206 692968 SGTC_430 0958-0115 16.4 µM 0.866410510075454 0.209782972209183 no 644 0.193132541180939 215 6833180 SGTC_2793 7325131 81.82 µM 0.865605961242879 0.210004777700975 no 645 0.193353142699774 213 4176441 SGTC_1352 1496-0991 99 µM 0.864947853039598 0.210186313499213 no 646 0.193533705521446 231 3000039 SGTC_901 1112-0062 60.1 µM 0.862053998866123 0.210985661447458 no 647 0.19432890179578 223 1908457 SGTC_3041 9091929 49.47 µM 0.859870154574979 0.211590066805331 no 648 0.194930311018385 210 25236887 SGTC_1336 1486-0901 104 µM 0.854304127347725 0.213135108493668 no 649 0.196468250459774 211 5006114 SGTC_2783 7738165 71.43 µM 0.850642080732789 0.214155214268067 no 650 0.197484103093477 230 17201110 SGTC_2618 avocadyne 43.43 µM 0.849308545217371 0.214527390600294 no 651 0.197854813583043 221 3015189 SGTC_1889 st059080 5.18 µM 0.849062126591881 0.214596204695415 no 652 0.197923361664491 206 176925 Isolated from Daphnopsis sellowiana. SGTC_3227 9130768 49.47 µM 0.84843434652782 0.214771574563763 no 653 0.198098060677299 217 17720899 SGTC_656 4090-1979 187 µM 0.848289765093016 0.214811975067868 no 654 0.198138308072616 222 22330961 SGTC_371 0195-0006 7.36 µM 0.848090533833293 0.214867653648803 no 655 0.1981937765265 213 3928593 SGTC_1495 4469-0029 237 µM 0.845482842459485 0.215597190158784 no 656 0.198920654138545 220 793680 SGTC_114 0364-0001 490.298 µM 0.845385930079485 0.215624330345578 no 657 0.198947698785392 230 4003655 SGTC_2100 5377183 190 µM 0.844680644901533 0.215821904208402 no 658 0.199144584427081 216 2844202 SGTC_3286 9117135 37.221 µM 0.844345393725424 0.215915856004041 no 659 0.199238213446866 224 3438150 SGTC_943 3253-1379 105 µM 0.844344741399478 0.21591603883692 no 660 0.199238395654434 228 668464 SGTC_197 4544-0043 41.561 µM 0.842390378955721 0.216464207050625 no 661 0.199784738282886 229 896523 SGTC_680 0417-1641 114 µM 0.842382389576292 0.216466449598627 no 662 0.199786973564328 213 2835990 SGTC_120 rhodamine 6G 52.259 µM 0.842089506147671 0.216548668661033 no 663 0.199868927345584 261 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_3056 9094900 49.47 µM 0.837622299770282 0.217804953004087 no 664 0.201121432281326 235 25236784 SGTC_1643 st009866 20.2 µM 0.836621981300639 0.218086841258383 no 665 0.201402542945126 212 3156273 YOR207C RET1 SGTC_258 haloperidol 50.781 µM 0.836126591430087 0.218226519208581 no 666 0.201541845129274 253 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_877 0771-0151 33.1 µM 0.836106538915642 0.218232174212718 no 667 0.201547485053138 214 6166523 SGTC_2317 5986382 200 µM 0.834843042463093 0.21858866274575 no 668 0.201903043805687 246 877883 SGTC_2833 9001315 45.46 µM 0.833936469386224 0.218844653767885 no 669 0.202158392480974 215 2989378 SGTC_2779 methotrexate 400 µM 0.833002516149916 0.219108556476748 no 670 0.202421655110901 231 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_137 0438-0332 85.389 µM 0.83260240897693 0.219221668814051 no 671 0.202534499968934 248 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_3023 9089636 49.47 µM 0.832522892777688 0.219244152446538 no 672 0.202556930924457 233 17249241 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.829325817638719 0.220149240000945 no 673 0.203460032780696 232 688803 SGTC_483 fpl-64176 144 µM 0.828731303252765 0.220317782189315 no 674 0.203628234202308 215 3423 SGTC_1842 st055362 61.2 µM 0.828187766645246 0.220471937115299 no 675 0.203782085405431 202 676032 SGTC_2247 cerulenin 830 nM 0.827211163715616 0.2207490712319 no 676 0.204058692592746 224 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_868 0527-0199 213 µM 0.826766579030212 0.220875298676765 no 677 0.204184688159603 212 2849450 SGTC_3317 9138495 8.753 µM 0.825393747899957 0.221265336569194 no 678 0.204574041642954 241 17020139 SGTC_1440 4100-1550 40 µM 0.825282638272574 0.221296921378459 no 679 0.204605573149323 249 742806 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.82383299767775 0.221709242699078 no 680 0.205017227721332 236 5282362 SGTC_3138 9097216 49.47 µM 0.822178961468661 0.222180235956312 no 681 0.205487525363739 247 25237486 SGTC_1992 st073643 23.3 µM 0.822027515019949 0.222223389439437 no 682 0.20553061862734 228 3161292 SGTC_2971 9092186 9.93 µM 0.821029302956876 0.222507941799304 no 683 0.205814788650379 215 25236400 SGTC_2706 st078239 82.5 µM 0.81974787511689 0.222873532600898 no 684 0.206179925772876 243 15434492 SGTC_2163 5671233 125 µM 0.819020772988847 0.223081126608265 no 685 0.206387280932641 234 701023 SGTC_67 0335-0847 266 µM 0.817353946932885 0.223557435286928 no 686 0.206863092867954 243 4552207 YOR254C SEC63 SGTC_3145 9085516 49.47 µM 0.816818963356462 0.223710433588112 no 687 0.207015946738938 225 25236195 SGTC_3333 9141820 12.094 µM 0.816804787716548 0.22371448844505 no 688 0.207019997868066 223 1939433 SGTC_1775 st081588 35.1725 µM 0.816713769650535 0.223740524613419 no 689 0.207046010223169 234 1426443 YGL099W LSG1 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.815543498113127 0.224075440007219 no 690 0.207380638253714 215 688664 SGTC_3280 9140961 49.47 µM 0.815332952502929 0.224135725435937 no 691 0.207440875689846 242 4901226 SGTC_21 0849-0113 22.993 µM 0.81458421736666 0.224350185036383 no 692 0.207655173784027 241 1560156 SGTC_944 3370-0224 231 µM 0.814235748885125 0.224450036289465 no 693 0.207754954749713 207 4580514 SGTC_981 1488-1094 54.9 µM 0.813464521638012 0.22467111581822 no 694 0.207975889743075 232 3449522 SGTC_2972 9093619 59.92 µM 0.812291355695302 0.225007651568293 no 695 0.208312234764651 214 25236256 SGTC_696 1560-0013 611 µM 0.811825092676162 0.225141483613509 no 696 0.208446000774395 246 1650269 SGTC_1364 1653-0028 37.6 µM 0.811337110484613 0.225281598023225 no 697 0.208586052025319 223 5718652 SGTC_879 0831-1030 162 µM 0.81044279319574 0.22553851163886 no 698 0.208842865699777 246 1549252 SGTC_1629 st005085 44.9 µM 0.810350090155239 0.2255651522433 no 699 0.208869497114984 257 24207091 SGTC_1045 1348-1485 165 µM 0.809801604721175 0.225722810082036 no 700 0.209027105084888 238 6810614 SGTC_1135 dihydrocapsaicin 536.708 nM 0.809264378794063 0.225877291876789 no 701 0.209181545499682 243 107982 A Capsaicinoid. SGTC_2342 7990637 118.86 µM 0.808110813902984 0.226209206720588 no 702 0.209513396463912 246 2033102 YER133W GLC7 SGTC_3147 9097027 49.47 µM 0.807595743691073 0.226357496649061 no 703 0.209661668879558 260 25236841 SGTC_3098 9119039 49.47 µM 0.807397186018252 0.226414676530516 no 704 0.209718843825644 227 17161528 SGTC_3171 9103192 49.47 µM 0.80677129610846 0.226594971291256 no 705 0.209899129643352 251 13018434 SGTC_1287 0971-0001 34.6 µM 0.806259569857338 0.226742440098481 no 706 0.210046598602538 225 4665869 SGTC_1037 k284-1091 78.7 µM 0.80591024550728 0.226843139167 no 707 0.210147301632294 225 3334711 SGTC_2194 5927483 104.545 µM 0.804007134854373 0.227392188173767 no 708 0.210696427223752 207 760979 SGTC_2773 thioridazine 9.09 µM 0.802168905903974 0.227923228802354 no 709 0.211227630142452 241 5452 An antipsychotic. SGTC_2018 5133068 143 µM 0.801903089545124 0.22800007741815 no 710 0.21130450941366 257 785362 SGTC_1659 st012954 42.1 µM 0.800974909553459 0.228268532383278 no 711 0.211573085671915 236 24207262 SGTC_1147 3809-1045 12.3 µM 0.800365001469544 0.228445031122638 no 712 0.211749676179556 226 325925 SGTC_2468 5987765 72.9 µM 0.799929769779257 0.228571027860556 no 713 0.211875744256625 221 26772094 SGTC_1789 tunicamycin 25 nM 0.797622473086256 0.229239626760762 no 714 0.212544802820603 249 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_966 1300-0360 30.2 µM 0.796233128221661 0.229642753770986 no 715 0.212948272795103 248 70588 SGTC_2729 fluphenazine 10.66 µM 0.793440029092746 0.230454389127772 no 716 0.213760748336569 256 3372 An atypical antipsychotic. SGTC_904 1141-0088 396 µM 0.79342018158652 0.230460162266157 no 717 0.213766528165984 247 1378119 SGTC_2227 7312221 64.1025 µM 0.788284813525633 0.231956624928568 no 718 0.215265064323303 263 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_117 lucigenin 22.078 µM 0.787314554640996 0.232239967981679 no 719 0.215548875801353 234 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_615 k087-0205 167 µM 0.787016203835091 0.232327133561119 no 720 0.21563619032322 250 9642773 SGTC_1366 1683-0113 21.9 µM 0.786900583735367 0.232360917792683 no 721 0.215670032894794 243 708623 SGTC_720 r052-1644 49.9 µM 0.786556639687309 0.232461434512874 no 722 0.215770725212089 240 1422863 YOR257W CDC31 SGTC_226 1,3-diallylurea 8.28947 mM 0.786513717087099 0.232473980223976 no 723 0.215783293052113 245 74537 YKL182W FAS1 SGTC_390 dec-rvkr-cmk 16.7 µM 0.786235747622487 0.23255523615428 no 724 0.215864693446973 221 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2511 berberine 10.47 µM 0.785404002723958 0.23279846580412 no 725 0.216108367333112 258 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1802 st050112 57.9 µM 0.78511357118243 0.2328834308541 no 726 0.216193491729652 242 4662563 SGTC_2232 chlorophetanol 41.5365 µM 0.784716456324594 0.232999633727925 no 727 0.216309916024036 244 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2105 5350118 200 µM 0.781926807823163 0.233816841503217 no 728 0.217128794616071 241 2133313 SGTC_1914 st062367 72.6 µM 0.781654936094121 0.233896569258912 no 729 0.217208696014313 243 978205 SGTC_412 gemfibrozil 100 µM 0.781541837482202 0.233929740433237 no 730 0.217241939989639 224 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1853 st056710 91.2 µM 0.781451904745213 0.233956119049415 no 731 0.217268376732327 241 269167 SGTC_768 0384-0033 77.3 µM 0.781006719451554 0.234086722816963 no 732 0.217399271333777 231 3965305 YMR134W ERG29 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.778347003546596 0.234867842841 no 733 0.218182236290986 252 5106787 A p450 inhibitor. SGTC_1769 st044406 64.4 µM 0.776536577890061 0.235400361565064 no 734 0.218716116138914 268 670903 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.775320654281862 0.235758387157432 no 735 0.219075103819505 258 2346 DNA damaging agent; causes G2/M arrest. SGTC_2913 7966556 36.57 µM 0.775265242412191 0.235774710190834 no 736 0.219091471614979 236 2976516 SGTC_1985 st071382 65.5 µM 0.774796846222866 0.235912713584004 no 737 0.219229856579509 258 6123237 SGTC_532 1548-0774 215 µM 0.774670830613319 0.235949849114577 no 738 0.219267095743053 265 5932993 SGTC_765 1319-0117 244 µM 0.773854409667232 0.236190518174577 no 739 0.219508446244662 232 3487746 YGL099W LSG1 SGTC_2691 st077356 60.2 µM 0.773250040221429 0.236368764581824 no 740 0.219687208298705 250 2839272 SGTC_306 1672-3436 11.6 µM 0.772948611708989 0.236457692427283 no 741 0.219776396883931 251 6797378 SGTC_1958 st076513 41.9 µM 0.772172312508813 0.236686802020943 no 742 0.220006188903244 256 732122 YGL099W LSG1 SGTC_2624 nerol 100 µM 0.771252224601412 0.236958506108648 no 743 0.220278722189165 264 637566 A natural product oil. SGTC_248 streptozotocin 5.23457 mM 0.770570654513676 0.237159885820511 no 744 0.220480730395967 264 5300 DNA alkylating agent. SGTC_1310 1188-0297 994 nM 0.770233586655384 0.237259512117141 no 745 0.220580671996544 233 1588352 SGTC_3355 9151058 44.0485 µM 0.769796126366415 0.237388845419415 no 746 0.220710418939085 244 17015728 SGTC_1931 st074438 57.1 µM 0.769733288390271 0.237407426382858 no 747 0.220729059729652 281 2787313 SGTC_2732 terfenadine 20 µM 0.769392176312022 0.237508305927949 no 748 0.22083026584302 267 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_834 0312-0008 75.7 µM 0.768731555910007 0.237703742872935 no 749 0.221026343890022 237 6385573 YIL048W NEO1 SGTC_1638 st008370 60.6 µM 0.767993006230783 0.237922338707273 no 750 0.2212456699608 245 24207134 SGTC_3066 9117245 49.47 µM 0.767142124414585 0.238174319171839 no 751 0.221498509413573 240 17176980 SGTC_2537 larixol 68.93 µM 0.766728003927794 0.238297009851395 no 752 0.221621625010927 248 6708759 SGTC_174 3553-0389 74.3 µM 0.76567945863761 0.238607815082987 no 753 0.221933526193022 239 738071 SGTC_2136 5328288 199.296 µM 0.764804921707772 0.238867211108232 no 754 0.222193858305612 242 262395 SGTC_1632 st005650 90 µM 0.76472623962631 0.238890556526625 no 755 0.222217288925705 242 2759605 SGTC_2735 sertaconazole 140 nM 0.764650481689355 0.238913035513858 no 756 0.2222398501014 273 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1465 k213-0056 144 µM 0.764581732062022 0.238933435988044 no 757 0.222260325290948 262 24048857 YMR208W ERG12 SGTC_1569 carminic acid 40.6 µM 0.764241607225593 0.23903437720825 no 758 0.2223616379714 241 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1158 4092-0494 91.8 µM 0.763847150780895 0.239151471988926 no 759 0.222479167344409 242 1148199 SGTC_1113 artemisinin 1.17947 µM 0.762868400005931 0.239442150455766 no 760 0.222770941756573 271 2240 An anti-malaria and mitochondrial poison. SGTC_1385 3091-4834 14.1 µM 0.76225803033349 0.239623521322965 no 761 0.222953008788351 225 4072814 SGTC_755 1995-0008 37.3 µM 0.762013876623054 0.239696092397229 no 762 0.22302586106969 227 689533 SGTC_2300 7976697 71.57 µM 0.761661118558015 0.239800965687423 no 763 0.22313114341372 230 2236109 SGTC_2142 5622915 118.518 µM 0.759741937169866 0.240371967495198 no 764 0.223704427859578 247 5322196 SGTC_3350 9150499 3.57 µM 0.75823237217357 0.240821618634179 no 765 0.22415594235729 263 4910996 YPR165W RHO1 SGTC_299 1273-0059 1.44 µM 0.758079759271979 0.240867102595899 no 766 0.224201618029383 243 2848077 SGTC_1195 1502-0147 41.1 µM 0.758031815168079 0.240881392573888 no 767 0.224215968360392 236 817940 SGTC_1662 st014054 52 µM 0.757451127392513 0.241054506060757 no 768 0.224389817622341 254 2838777 SGTC_580 1123-0028 41 µM 0.757004806882075 0.241187608210874 no 769 0.224523491314004 268 1677248 YPR107C YTH1 SGTC_906 1165-0455 526 µM 0.756506257076923 0.241336333455207 no 770 0.224672861170595 254 3252859 SGTC_581 0958-0271 211 µM 0.755773449737483 0.241555031824937 no 771 0.224892518897305 245 4591145 SGTC_1963 st076565 50.3 µM 0.755122378897967 0.241749427072723 no 772 0.225087778337406 270 4914280 SGTC_1474 0330-0125 5.35 µM 0.754700828979972 0.241875337757415 no 773 0.225214254505837 252 X1474 SGTC_3272 9137413 49.47 µM 0.752393299973797 0.242565192323542 no 774 0.225907287298833 267 17614870 SGTC_2607 solasodine 47.35 µM 0.752200636470489 0.242622838801847 no 775 0.225965205475245 269 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_3161 9100388 49.47 µM 0.751375713189908 0.242869746374361 no 776 0.226213287419838 265 25236368 SGTC_2429 5902844 64.44 µM 0.749632303262243 0.243392012955061 no 777 0.226738094894964 259 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2792 7535235 81.82 µM 0.748906082914404 0.243609742887936 no 778 0.226956906864297 246 1281891 SGTC_2697 mebhydrolin 72.4 µM 0.748851802584707 0.243626021032506 no 779 0.226973266442363 258 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2822 7994718 71.43 µM 0.747998162355974 0.24388209669656 no 780 0.227230632984669 292 1018011 SGTC_1105 epirubicin 18.1 µM 0.747459014047023 0.244043905635489 no 781 0.227393267123252 261 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1349 flufenamic acid 69 µM 0.746430983973599 0.244352597948384 no 782 0.227703554140569 260 3371 A non-steroidal anti-inflammatory. SGTC_1133 3473-0247 50 µM 0.744190908623563 0.24502596606111 no 783 0.228380493673833 247 711311 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.743740822892511 0.245161382459392 no 784 0.228516643635339 247 5379071 SGTC_2104 5389443 200 µM 0.743672398962923 0.245181972554551 no 785 0.228537345718197 248 2244536 SGTC_2877 9040724 71.43 µM 0.741813947045237 0.245741572439469 no 786 0.229100034567364 244 6463895 SGTC_1703 st026983 48.3 µM 0.740833755477553 0.246036994662102 no 787 0.229397122734065 264 1104023 SGTC_309 k408-0051 1.48 µM 0.740545424896159 0.246123931539742 no 788 0.229484554494176 259 3640463 SGTC_2830 7992007 71.43 µM 0.739371545844326 0.246478047297291 no 789 0.229840707750523 259 1952075 SGTC_2287 7945887 168.79 µM 0.736067032771375 0.247476360465082 no 790 0.230844952249542 250 1245853 SGTC_2936 9038235 15.59 µM 0.735487176017429 0.247651761225916 no 791 0.231021423607223 255 4749415 SGTC_1186 1319-0216 26 µM 0.735046059069728 0.247785239063558 no 792 0.231155721846283 267 4565136 SGTC_3102 9121669 49.47 µM 0.734584090099113 0.24792506769239 no 793 0.231296415181104 277 41905072 SGTC_2436 5633522 8.09 µM 0.733292038120133 0.248316369089357 no 794 0.231690165030902 264 5724242 SGTC_1438 4092-1045 4 µM 0.732965649792832 0.248415268733011 no 795 0.231789690180731 277 1351342 SGTC_1812 st052057 4.327 µM 0.732905925111373 0.248433368311859 no 796 0.231807904524306 253 3645418 SGTC_399 oxolinic acid 75 µM 0.732403925280454 0.248585527255286 no 797 0.231961031827906 254 4628 A DNA gyrase inhibitor. SGTC_1293 1000-1278 195 µM 0.731047638335139 0.248996873517542 no 798 0.232375027772872 280 678847 SGTC_1219 1469-0211 33.1 µM 0.730587330803555 0.249136561785558 no 799 0.232515626394781 273 6822282 SGTC_2482 5981709 142.65 µM 0.728206512211762 0.24985972714789 no 800 0.233243590015478 270 877755 SGTC_3243 9134147 49.47 µM 0.727285851886979 0.250139672986474 no 801 0.233525431655882 268 24282180 SGTC_2749 bexarotene 57.39 µM 0.724452312884424 0.251002312121078 no 802 0.234394046740425 266 82146 An retinoic acid receptor inhibitor. SGTC_2112 5488546 200 µM 0.724098014517868 0.251110284893745 no 803 0.23450278172738 275 600757 SGTC_444 curcumin 90.4 µM 0.721185230601699 0.251998889134158 no 804 0.23539777877152 252 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1898 st060199 18.6 µM 0.720697305391736 0.252147902772636 no 805 0.235547885331525 263 688866 SGTC_165 k038-0023 64.381 µM 0.719901205749224 0.252391133433327 no 806 0.235792912795556 262 46368543 SGTC_837 0091-0265 12.5 µM 0.718880093458416 0.252703292685999 no 807 0.236107401382446 273 759367 SGTC_1212 0520-0165 585 µM 0.718879685251761 0.252703417517506 no 808 0.236107527150689 286 5403258 SGTC_2264 7948757 110.76 µM 0.716506843201788 0.253429592110978 no 809 0.236839221766334 255 2971411 SGTC_2062 5245942 200 µM 0.714956912847503 0.253904517724527 no 810 0.237317833950724 266 1376160 SGTC_3154 9100113 49.47 µM 0.713807542584926 0.254257006152452 no 811 0.237673097508331 268 25237525 SGTC_2029 5175081 200 µM 0.713470575629673 0.254360395662852 no 812 0.23777730728814 258 1380876 SGTC_1683 st010134 710 nM 0.711330714247687 0.255017470191379 no 813 0.238439661426114 275 3818134 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.710725617130521 0.25520343469796 no 814 0.23862714100042 244 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2553 4-methylesculetin 85.09 µM 0.710637961889882 0.255230379663256 no 815 0.238654306249898 258 5319502 SGTC_212 3807-4682 38.772 µM 0.710577035325445 0.255249109187675 no 816 0.23867318900799 267 3125501 YBL034C STU1 SGTC_2434 5670830 169.91 µM 0.70994288232075 0.255444097747599 no 817 0.23886977837298 281 1549830 SGTC_2598 perillyl alcohol 100 µM 0.709605771182165 0.255547783928531 no 818 0.23897431989486 260 10819 An apoptosis inducer. SGTC_2225 6654152 15.4 µM 0.709420285600056 0.255604843603505 no 819 0.239031851488522 264 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_3220 9131269 49.47 µM 0.709352197572589 0.255625790732359 no 820 0.239052972079417 276 17722206 SGTC_1168 k815-0004 80.5 µM 0.708918020676029 0.255759385363353 no 821 0.239187675733176 278 642433 SGTC_1311 1190-0148 100 µM 0.708821012253009 0.255789239478632 no 822 0.239217778325173 275 1961333 SGTC_1429 4049-0205 9.46 µM 0.707792289579711 0.256105938369575 no 823 0.239537127621829 253 22774478 SGTC_348 k064-0012 10.7 µM 0.706526225535774 0.256495984861826 no 824 0.239930474755855 270 5066323 SGTC_8 0354-0001 70 µM 0.706029318056269 0.256649155651933 no 825 0.24008495267485 255 4993152 SGTC_1588 farnesol 29.9 µM 0.704926156616885 0.256989373246811 no 826 0.240428095717719 267 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2566 crystal violet carbinol 226 nM 0.7042105360433 0.25721019771912 no 827 0.240650835296317 294 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_3156 9099931 49.47 µM 0.703988645643901 0.257278688154213 no 828 0.240719922319287 278 18111053 SGTC_225 nsc-122657 1.016 µM 0.69798309477463 0.259136002736684 no 829 0.242593883171734 272 275685 SGTC_2897 9048598 12.99 µM 0.69687489935422 0.259479486259924 no 830 0.242940543722575 278 6467404 SGTC_1184 1269-1718 139 µM 0.696432498117481 0.259616673508331 no 831 0.243079008436539 266 5403821 SGTC_3088 9117578 49.47 µM 0.69633824316483 0.259645906514171 no 832 0.243108514286498 280 678341 SGTC_1720 st037298 9.481 µM 0.695370509771734 0.259946145558219 no 833 0.243411568411228 284 597396 SGTC_1764 st044502 93.5 µM 0.695061165345105 0.260042157343478 no 834 0.243508485343159 259 8407 SGTC_1737 st035557 69.7 µM 0.694450918399435 0.260231614384071 no 835 0.243699735479217 277 5716916 SGTC_621 3584-0052 32.1 µM 0.692153983029349 0.260945357292389 no 836 0.244420316798527 285 2273927 SGTC_2250 alverine citrate 130 µM 0.692030503698593 0.260983755388919 no 837 0.244459086513874 264 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_3167 9103034 49.47 µM 0.690817993224845 0.261360961386291 no 838 0.244839963308849 265 5127859 SGTC_1328 1441-0025 69.2 µM 0.690615649584017 0.261423936742828 no 839 0.244903555078021 270 4562601 SGTC_3298 9116858 71.43 µM 0.689249162282931 0.261849432125231 no 840 0.245333241965999 293 2506942 SGTC_3206 9114350 49.47 µM 0.688518407939225 0.262077119319645 no 841 0.245563191155329 260 17087243 SGTC_538 2922-0838 53.3 µM 0.687085039688508 0.262524020299137 no 842 0.24601457053826 265 777039 SGTC_2713 st079149 53.4 µM 0.686894313876162 0.262583514906343 no 843 0.246074665194146 273 3103253 SGTC_2086 5274770 176.623 µM 0.686857647806203 0.262594953233511 no 844 0.246086218989249 273 689278 SGTC_2653 dihydrofissinolide 100 µM 0.686334042498692 0.262758324675032 no 845 0.246251243284008 270 6857746 SGTC_2585 alliin 100 µM 0.684443664146956 0.26334857886139 no 846 0.246847525887632 284 87310 A garlic compound which reacts with lipids. SGTC_2414 st077232 92.9 µM 0.683979107945477 0.263493736055591 no 847 0.246994179202051 263 729801 SGTC_623 k072-0108 16.9 µM 0.683794620471391 0.26355139311808 no 848 0.247052432016882 275 5382803 SGTC_1144 3486-0183 12.5 µM 0.680454901188936 0.264596252960881 no 849 0.248108234240935 299 6744069 SGTC_3052 9092717 49.47 µM 0.680348054732589 0.26462971554541 no 850 0.248142051834861 287 25237534 SGTC_1892 st058411 7.36 µM 0.680244029751201 0.264662296557487 no 851 0.248174978775595 284 3934738 SGTC_789 1309-1135 70.6 µM 0.679933434516732 0.26475958828142 no 852 0.248273305090419 266 3092424 SGTC_2807 7945238 51.95 µM 0.679733075511917 0.26482235894669 no 853 0.248336744522174 277 17148797 SGTC_2472 5377652 49.4 µM 0.679647713880187 0.264849104272402 no 854 0.248363775098262 295 1610903 SGTC_1459 k035-0031 35.7 µM 0.677969357478574 0.265375242088383 no 855 0.248895561097103 266 3877128 YMR208W ERG12 SGTC_2268 7933382 153.85 µM 0.677895232655034 0.265398491257136 no 856 0.248919061459568 272 935025 YOR257W CDC31 SGTC_2459 5811157 9.22 µM 0.677879699062206 0.26540336348231 no 857 0.248923986343546 280 2870684 YBR192W RIM2 SGTC_2412 st077135 33.4 µM 0.676675131999492 0.265781322949443 no 858 0.249306048986742 301 13258915 SGTC_984 1492-0255 2.91 µM 0.67661040582032 0.265801639936359 no 859 0.249326587554897 275 1585198 SGTC_3011 9081274 71.4286 µM 0.676015708661917 0.265988347058176 no 860 0.249515335798298 279 6625322 SGTC_3296 9122258 64.045 µM 0.675077615649072 0.266282999430058 no 861 0.249813227172929 270 4730474 SGTC_1409 3909-8004 61.9 µM 0.674726336581883 0.266393377693204 no 862 0.249924824388115 265 2119279 SGTC_688 0527-0193 473 µM 0.674287712171781 0.266531233941102 no 863 0.250064207325227 304 4007154 SGTC_3217 9129673 49.47 µM 0.674213913464507 0.266554431847432 no 864 0.250087662604588 282 17248312 SGTC_3022 9087993 49.47 µM 0.67414063686633 0.266577466644053 no 865 0.25011095309789 278 17173644 SGTC_2405 ticlatone 3.52 µM 0.672900428461133 0.266967483828971 no 866 0.250505319799424 261 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_3208 9114115 49.47 µM 0.672048023282835 0.267235712782535 no 867 0.250776562130832 281 650895 SGTC_1285 0929-0069 65.5 µM 0.671276104043291 0.267478732272819 no 868 0.251022327284938 273 1206237 SGTC_876 0720-0963 56.8 µM 0.670843043580532 0.267615119325846 no 869 0.251160261703144 294 765861 SGTC_190 3970-0790 3.722 µM 0.668907267788428 0.268225196303127 no 870 0.251777316893783 278 2832352 SGTC_1953 st076800 12.1 µM 0.668017807525158 0.268505752074307 no 871 0.252061112760184 274 297591 SGTC_2622 2-methoxyxanthone 59.94 µM 0.667480658002149 0.268675252531601 no 872 0.252232580207722 268 71034 A hepatoprotective. SGTC_2802 7925815 54.55 µM 0.665963428760307 0.269154312699675 no 873 0.252717238143542 279 1262923 SGTC_1384 3089-0840 101 µM 0.665304967139517 0.269362353074557 no 874 0.252927727113121 268 1069836 SGTC_1458 k015-0034 6.33 µM 0.66527440684132 0.269372010531597 no 875 0.252937498496054 287 3598957 SGTC_3193 9111931 49.47 µM 0.665190974477558 0.269398377142166 no 876 0.252964176262178 320 17087244 SGTC_998 3996-0085 177 µM 0.664923130483482 0.26948303095562 no 877 0.253049830244841 292 715391 SGTC_1995 st072814 61.1 µM 0.664886952275163 0.269494466332543 no 878 0.253061400864153 278 5769371 SGTC_3134 9127454 49.47 µM 0.664195683944744 0.26971301236113 no 879 0.253282537759169 296 24262820 SGTC_2069 5228469 200 µM 0.661997158105105 0.270408670793238 no 880 0.253986521502492 295 2835210 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.659972617175327 0.271050068981838 no 881 0.254635700908013 297 23665772 A membrane-active detergent. SGTC_715 0868-0130 184 µM 0.659826113033047 0.271096512630161 no 882 0.254682711906432 292 2876258 SGTC_2682 pyrogallin 40.03 µM 0.65806234916228 0.271655959182937 no 883 0.255249034014076 272 822798 An ATP competetive kinase inhibitor. SGTC_184 1494-0393 24.714 µM 0.657717487859815 0.271765412545204 no 884 0.255359841485748 293 3090647 SGTC_1518 st038567 90.8 µM 0.657613305244085 0.271798482727324 no 885 0.255393321372378 308 77966 SGTC_1019 4262-0212 3.4 µM 0.656680860692289 0.272094553214999 no 886 0.255693071730834 289 4677213 SGTC_529 4076-0302 30.3 µM 0.656482227080825 0.272157644217434 no 887 0.255756949652208 288 5816522 SGTC_1622 st003707 19.4 µM 0.656258334503146 0.272228766815679 no 888 0.255828960506791 268 10140899 SGTC_2011 4012611 177 µM 0.655864338126775 0.272353947681689 no 889 0.255955707755631 281 2049887 SGTC_3263 9137018 49.47 µM 0.655636365400874 0.272426392428781 no 890 0.256029060740862 284 43844957 SGTC_370 0180-0345 38.7 µM 0.654709385042159 0.272721065057006 no 891 0.256327440810541 268 3989527 SGTC_1107 amlodipine 47 µM 0.65405083582965 0.272930503648258 no 892 0.256539527275403 253 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1947 st076332 61.6 µM 0.653091401881758 0.273235775368109 no 893 0.256848677497392 296 24208416 SGTC_2305 7443522 69.23 µM 0.651252895165131 0.273821221792559 no 894 0.257441625129064 281 5415886 SGTC_1463 k081-0032 34.1 µM 0.651122834382673 0.273862661287342 no 895 0.257483598716393 276 977755 SGTC_685 1278-0033 54.9 µM 0.650950670850584 0.273917520175886 no 896 0.257539165290344 296 3590572 SGTC_3159 9100096 49.47 µM 0.65055367671175 0.27404404070606 no 897 0.257667320715214 277 25236875 SGTC_40 0327-0103 19.753 µM 0.648411537386473 0.274727230291489 no 898 0.25835940505133 282 409036 SGTC_1563 conessine 56.1 µM 0.648335938305451 0.274751356337067 no 899 0.258383847256106 290 441082 An anti-amoebic, histamine inhibitor. SGTC_2160 5660466 132.927 µM 0.647841244262432 0.274909254550003 no 900 0.258543818092545 291 2859134 SGTC_406 estrone 100 µM 0.647593599043459 0.274988315628831 no 901 0.258623919200764 287 5870 A steroid. SGTC_2049 5262831 67.185 µM 0.646570002046762 0.275315219176598 no 902 0.258955138994143 289 763417 SGTC_387 norethindrone acetate 66.7 µM 0.646447293520821 0.275354421118677 no 903 0.258994860255146 295 541197 SGTC_2907 7721985 69.9 µM 0.644983809442671 0.275822174976417 no 904 0.25946883894133 273 3267881 SGTC_1165 k072-0275 30.3 µM 0.643722689383793 0.276225562864864 no 905 0.259877637050565 292 6153523 YGL055W OLE1 SGTC_1670 st016595 4.04 µM 0.642768603843785 0.276530933465843 no 906 0.260187129066651 309 597879 SGTC_2701 st077767 14.721 µM 0.641452970886537 0.276952294480383 no 907 0.26061421338385 289 5721188 SGTC_3074 9116018 49.47 µM 0.640093665810176 0.277387972378866 no 908 0.261055853385161 335 17027303 SGTC_1269 0831-0796 3.05 µM 0.639499040413908 0.277578664135948 no 909 0.261249168851001 288 927758 SGTC_213 1246-0773 967 nM 0.639146999894982 0.277691590981183 no 910 0.261363653504251 287 6251622 SGTC_950 1165-0508 94.1 µM 0.637961301495879 0.27807210189756 no 911 0.261749435710114 293 6148369 SGTC_2217 6934799 96.0675 µM 0.637415194283555 0.278247442566444 no 912 0.261927216917937 284 675606 SGTC_1152 3909-8331 15.9 µM 0.63675734768729 0.278458731367307 no 913 0.262141456250274 305 16001939 SGTC_400 oxethazaine 37.5 µM 0.636203362382383 0.278636722354011 no 914 0.262321940948349 291 4621 A local anesthetic. SGTC_1404 3909-7820 48.3 µM 0.635587788343926 0.278834566261231 no 915 0.26252256546694 283 23741373 SGTC_1387 3342-1166 1.8 µM 0.634755007318249 0.279102328685673 no 916 0.262794105839587 287 3418228 SGTC_1078 idebenone 36.1 µM 0.63157684217937 0.280125345246985 no 917 0.263831711387042 309 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_616 4092-0450 108 µM 0.631349790940644 0.280198500044223 no 918 0.263905918812497 317 787165 SGTC_1314 1222-0010 41.1 µM 0.631300327188189 0.280214438250799 no 919 0.263922086520655 298 3526027 SGTC_985 1493-0307 8.71 µM 0.629745695378854 0.280715595300959 no 920 0.26443049020705 302 3278274 SGTC_2425 5628681 7.85 µM 0.628773371000596 0.281029257705258 no 921 0.264748717897484 304 5714958 SGTC_1033 k072-0102 21.3 µM 0.628058056846978 0.281260119169262 no 922 0.264982954123967 288 5965931 SGTC_1778 st046819 58.9 µM 0.627770815390188 0.281352849627976 no 923 0.265077043615794 305 671715 SGTC_2969 9091408 28.7 µM 0.62642059349912 0.281788940768656 no 924 0.265519552760891 298 4286311 SGTC_1391 3442-0225 151 µM 0.626140865015604 0.28187932746478 no 925 0.265611275206351 293 5227075 SGTC_3126 9127922 49.47 µM 0.624615011029746 0.282372611696098 no 926 0.266111882599806 323 45595682 SGTC_3353 9151644 39.2805 µM 0.624454333695119 0.282424580269547 no 927 0.266164625960927 294 4909158 SGTC_1334 1486-0610 236 µM 0.624158682080986 0.282520216182692 no 928 0.266261689318733 290 3742339 SGTC_2001 4023502 57.655 µM 0.622675349340278 0.283000272168396 no 929 0.266748942423301 295 108941 YCR052W RSC6 SGTC_1218 1348-1416 30.7 µM 0.622416557742529 0.283084065868463 no 930 0.266833997824999 290 6787668 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.620911627892016 0.283571580398062 no 931 0.267328885022068 288 688667 SGTC_2698 st077697 67.5 µM 0.620690820328394 0.283643143735836 no 932 0.267401535208412 290 3154499 SGTC_2071 5230951 39.92 µM 0.620293424785162 0.283771960714539 no 933 0.267532311522924 309 1799272 SGTC_2480 5767542 37.17 µM 0.619923966334193 0.283891746921265 no 934 0.267653923122176 298 2867358 SGTC_1282 0886-0010 32.4 µM 0.619061110964306 0.284171597019703 no 935 0.26793805060825 296 2836211 YNL267W PIK1 SGTC_2444 5485484 36.41 µM 0.617324148218989 0.284735346300077 no 936 0.268510470983819 324 6790631 SGTC_2385 9074692 200 µM 0.617106857354591 0.284805907851954 no 937 0.268582122966246 283 17046906 SGTC_2210 7115885 190.385 µM 0.616686879388337 0.284942312273277 no 938 0.26872063855005 310 2927039 SGTC_1330 1469-0054 61.8 µM 0.615188238586776 0.285429308830824 no 939 0.269215207074389 307 7102664 SGTC_3015 9080845 49.47 µM 0.614802870872427 0.285554601502475 no 940 0.269342456568193 290 5296973 SGTC_2813 7971799 71.43 µM 0.614428465601584 0.2856763550758 no 941 0.269466115110475 299 2234054 SGTC_764 1951-2361 146 µM 0.614365248122212 0.28569691532706 no 942 0.269486997382135 304 5438930 SGTC_1727 st034309 9.9045 µM 0.614228328403604 0.285741448206427 no 943 0.269532228077293 331 870305 SGTC_897 1000-0139 31.4 µM 0.613176564185889 0.286083642580927 no 944 0.269879799554028 296 6151020 SGTC_2357 9067248 200 µM 0.61114298365917 0.286745825211679 no 945 0.270552462841917 316 9150235 SGTC_1484 3473-2379 286 µM 0.609336587973668 0.287334639701735 no 946 0.271150680035697 299 671917 SGTC_1943 st076331 65.2 µM 0.60920157828964 0.287378670554575 no 947 0.271195417155063 307 24208415 SGTC_679 0422-0091 41.4 µM 0.608602612795406 0.28757405029347 no 948 0.271393936106191 307 627384 YHR062C RPP1 SGTC_638 3970-0837 4.09 µM 0.607414749636274 0.287961711338037 no 949 0.271787851227875 294 4118451 YLR208W SEC13 SGTC_1028 k015-0029 4.8 µM 0.607037188162741 0.288084980781707 no 950 0.271913116438364 300 4588309 SGTC_1513 0337-0559 19 µM 0.60579870912655 0.288489504543515 no 951 0.272324213515568 294 775073 SGTC_90 0870-0863 4.608 µM 0.605546925641736 0.288571777183034 no 952 0.272407827536056 327 1738164 SGTC_1826 st055655 41.6 µM 0.605385520233286 0.288624523743436 no 953 0.272461434879188 303 676168 SGTC_885 0865-0106 16.8 µM 0.604479682414678 0.288920631693993 no 954 0.272762386643636 303 2793380 SGTC_89 0302-0250 142.109 µM 0.604169240065902 0.289022144603218 no 955 0.272865564643317 310 4203518 YLR208W SEC13 SGTC_2516 gossypol 71.55 µM 0.603310009958382 0.289303195482465 no 956 0.273151237541697 311 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2481 5478948 45.16 µM 0.603107031754922 0.289369607625491 no 957 0.273218744441168 291 77792 SGTC_1511 0906-3109 28.5 µM 0.60220515579239 0.289664777695049 no 958 0.273518792080048 292 2882180 SGTC_103 0844-0104 51.839 µM 0.60124313940186 0.289979786480348 no 959 0.27383902767393 302 5375804 SGTC_2098 5376439 882.5 nM 0.601003414842842 0.290058308411293 no 960 0.273918855924711 306 2844116 SGTC_2683 piperine 63.03 µM 0.600187684385979 0.290325576067625 no 961 0.274190580216715 313 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2344 7990960 76.95 µM 0.598427835721927 0.290902569063063 no 962 0.274777248518487 307 140813 SGTC_1515 3460-0031 42.1 µM 0.597205859045992 0.291303527596001 no 963 0.275184973950886 301 2876596 SGTC_162 k030-0015 37.8 µM 0.59674586366666 0.291454529408615 no 964 0.27533853340513 328 1809920 YMR134W ERG29 SGTC_795 0685-0265 78 µM 0.596027166358594 0.291690527875281 no 965 0.275578539254205 297 302754 SGTC_1786 berberine 21.6 µM 0.59540267938272 0.291895662808021 no 966 0.275787167469919 310 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_806 3966-4455 5.86 µM 0.594833891323911 0.292082559901682 no 967 0.275977255343147 299 714982 SGTC_2159 5658611 73.75 µM 0.594629888802397 0.292149606309309 no 968 0.276045448267384 325 793844 SGTC_3169 9102970 49.47 µM 0.593613710143125 0.292483684940827 no 969 0.276385254496598 312 17027839 SGTC_3258 9138477 49.47 µM 0.592103129324747 0.292980630998996 no 970 0.276890765778238 321 4970355 SGTC_1685 st024049 53.0905 µM 0.59080343366637 0.293408514017803 no 971 0.27732606703516 322 1941139 SGTC_2911 7942208 15.64 µM 0.590689701666772 0.293445970394562 no 972 0.277364174702822 273 1243384 SGTC_2841 9004761 38.96 µM 0.59065800541203 0.293456409600322 no 973 0.277374795479993 266 2991039 SGTC_1292 0kpi-0043 232 µM 0.590246998707945 0.293591790807353 no 974 0.277512533559843 310 3333905 SGTC_3326 9140064 16.379 µM 0.586821064595923 0.294721380222534 no 975 0.278661944013467 325 1868434 SGTC_1123 mangostin 811.285 nM 0.585747065514291 0.295075908382627 no 976 0.279022750350821 279 5281650 An antioxidant. SGTC_287 k060-0039 29.6 µM 0.582729293710818 0.296073127654316 no 977 0.280037774939248 305 5861974 SGTC_134 0269-0018 6.916 µM 0.582714229956875 0.296078109332151 no 978 0.280042846104368 319 4378915 SGTC_1056 3448-1962 115 µM 0.582518235220834 0.296142929525707 no 979 0.280108831169493 312 715507 SGTC_1244 0416-0015 52.5 µM 0.581027572352038 0.296636140684935 no 980 0.28061093539976 315 96201 SGTC_2322 7413319 38.22 µM 0.580231831390888 0.296899579041835 no 981 0.280879145259054 302 1840400 SGTC_591 4299-0174 154 µM 0.58002419098993 0.296968338173375 no 982 0.280949152239162 318 5509088 SGTC_2826 7992541 19.48 µM 0.579920298043321 0.297002744562789 no 983 0.280984183420973 355 2985066 SGTC_3067 9117431 49.47 µM 0.577668236047375 0.297749011159854 no 984 0.281744064117456 330 17150885 SGTC_2930 9013230 14.89 µM 0.57743351286198 0.29782684066579 no 985 0.281823320333401 304 2995857 SGTC_2832 7992762 51.95 µM 0.575740227089297 0.298388574980936 no 986 0.282395390322376 286 2985177 SGTC_1787 fluconazole 80 µM 0.575476778557872 0.298476015302052 no 987 0.282484445567853 300 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_962 1254-0300 21.5 µM 0.575426530957207 0.298492694138942 no 988 0.282501432629268 303 7340576 SGTC_1800 st050079 29.0735 µM 0.574408874947249 0.298830578968683 no 989 0.282845574328051 321 3645560 SGTC_1562 morin hydrate 59.1 µM 0.573942855619255 0.298985365928979 no 990 0.2830032357143 313 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2251 lansoprazole 556 µM 0.573793723643361 0.299034907369114 no 991 0.283053698225969 319 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2173 5763948 167 µM 0.573262500082508 0.299211409394144 no 992 0.283233486007268 305 2867177 SGTC_2755 lomerizine 42.69 µM 0.571172908484633 0.299906146231405 no 993 0.28394122028693 309 3949 A calcium channel blocker. SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.570877818605978 0.300004315026904 no 994 0.284041233915738 330 6710655 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.569232546848982 0.300551920837648 no 995 0.284599167977413 311 75037 A free radical scavenger. SGTC_3028 9087778 49.47 µM 0.568386112485386 0.300833820458386 no 996 0.284886409119652 304 17217395 SGTC_1673 st016611 27.3 µM 0.567729183567687 0.301052688655952 no 997 0.28510943605027 340 5226799 SGTC_2448 5185112 27.17 µM 0.567064400659542 0.301274246591646 no 998 0.285335214098199 296 5718189 SGTC_2838 9002687 71.43 µM 0.566393402660019 0.301497950319587 no 999 0.285563189283288 318 6457060 SGTC_2881 9058953 51.95 µM 0.566040711986827 0.301615563668958 no 1000 0.285683052589445 267 17122249 SGTC_1051 3253-3903 78 µM 0.565533522748566 0.301784734517886 no 1001 0.285855464788064 309 5509239 SGTC_311 1315-0136 58 µM 0.565030645640591 0.301952509169972 no 1002 0.286026459967279 321 6759207 SGTC_1074 carmofur 3.8 µM 0.563199310842373 0.302563850355631 no 1003 0.286649586060463 311 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1070 indatraline 8.81 µM 0.560930028353844 0.303322157056506 no 1004 0.287422619223788 339 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_97 0535-0701 19.132 µM 0.55852091026411 0.304128119634299 no 1005 0.288244364958369 316 2832013 YGL099W LSG1 SGTC_1156 4092-0367 4.88 µM 0.558430606630672 0.304158348967264 no 1006 0.288275188895792 324 1357585 SGTC_1986 st071812 45 µM 0.557441206485351 0.304489640411157 no 1007 0.288613009178619 319 11838594 SGTC_2360 9040895 200 µM 0.557037159090673 0.304624978087674 no 1008 0.288751020523813 299 4914414 SGTC_1699 st031318 29.054 µM 0.549576779776363 0.307128659855245 no 1009 0.29130484445263 326 5340658 SGTC_1054 3429-0080 167 µM 0.54843357798592 0.307513114823627 no 1010 0.291697112844371 330 1162877 SGTC_1836 st055642 81 µM 0.546573786243472 0.308139008499952 no 1011 0.292335791230081 340 8571 SGTC_562 3772-2733 112 µM 0.545843720103476 0.308384857422202 no 1012 0.292586683735707 323 2876874 YIL048W NEO1 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.545575007976315 0.308475367565319 no 1013 0.292679053782483 354 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1617 st002906 78 µM 0.543766968480926 0.309084670866183 no 1014 0.293300920950565 332 5150859 SGTC_36 0335-0881 14.2 µM 0.54338106295314 0.309214787863882 no 1015 0.293433730706802 315 23828853 SGTC_1047 2043-3044 82 µM 0.542931406578134 0.309366430127778 no 1016 0.293588515511139 363 669592 SGTC_1062 mesoridazine 14.2 µM 0.542473585766191 0.309520859131678 no 1017 0.293746149580186 315 4078 A neuroleptic. SGTC_1478 0453-0656 35.7 µM 0.541138505983487 0.309971391176892 no 1018 0.29420605959484 335 5258496 SGTC_160 3453-0671 289.699 µM 0.54062464537829 0.310144873173075 no 1019 0.294383163580933 328 5322268 SGTC_2534 helenine 20.12 µM 0.540457799209972 0.310201210393124 no 1020 0.294440678323049 331 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1745 st081495 74 µM 0.540189804560224 0.310291710698834 no 1021 0.294533071540886 320 13842402 YBL026W LSM2 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.539865096512095 0.310401378197217 no 1022 0.294645035061023 304 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2438 5259590 200 µM 0.539017347807805 0.310687777858428 no 1023 0.294937442240759 347 1201127 SGTC_44 0929-0055 61.211 µM 0.537337526098678 0.31125562025198 no 1024 0.295517244346138 310 1379590 SGTC_1276 0871-0068 94.2 µM 0.536208445756116 0.31163754419699 no 1025 0.295907248556154 334 3414906 SGTC_1756 st041558 35.5 µM 0.535587431009784 0.311847695764379 no 1026 0.296121858675366 339 3955792 SGTC_2450 5739737 12.93 µM 0.532441121410771 0.312913348320484 no 1027 0.297210255443461 328 2262825 SGTC_1423 4048-0112 5.59 µM 0.531895427796202 0.313098333828207 no 1028 0.297399212087933 329 X1423 SGTC_208 k072-0098 12.366 µM 0.530779796046792 0.313476669925169 no 1029 0.297785691158547 323 5948901 SGTC_1879 gemcitabine 100 µM 0.53057242855308 0.313547014607378 no 1030 0.297857553002994 358 60750 A nucleoside analog which inhibits DNA replication. SGTC_1393 3470-5649 58.2 µM 0.530568861726423 0.313548224631122 no 1031 0.297858789132549 312 4108395 SGTC_2800 7887935 81.82 µM 0.527503155208889 0.314588987295616 no 1032 0.298922112961628 331 2961002 SGTC_838 0109-0203 71.4 µM 0.526212228785085 0.315027679806537 no 1033 0.299370379183161 303 759422 SGTC_1704 st028805 70.8 µM 0.525133364184565 0.315394508136245 no 1034 0.299745241932991 328 2876101 SGTC_139 0099-0334 718.624 µM 0.524603582891405 0.315574707496146 no 1035 0.299929397756852 329 97690 SGTC_1344 1488-0097 29.1 µM 0.524525935989888 0.315601121933713 no 1036 0.299956392685454 340 747966 SGTC_773 4358-1457 44.6 µM 0.524386893219453 0.315648424778806 no 1037 0.300004735412501 355 1186886 SGTC_1151 3909-8316 15.3 µM 0.52417859033945 0.315719295811126 no 1038 0.300077165257864 338 800431 SGTC_965 1291-5240 308 µM 0.522649212677168 0.316239844412898 no 1039 0.300609193468183 339 2834598 SGTC_891 0929-0073 133 µM 0.522561216535407 0.316269806429162 no 1040 0.300639817845351 361 5603632 SGTC_900 1112-0045 141 µM 0.52255940208951 0.316270424246869 no 1041 0.300640449322804 318 56211 YIL048W NEO1 SGTC_1114 scopoletin 1.73284 µM 0.521996041573115 0.316462272948815 no 1042 0.300836543339229 330 5280460 A coumarin with genotoxic properties. SGTC_1911 st060208 74.3 µM 0.521910361355767 0.316491455109784 no 1043 0.30086637188531 356 688783 SGTC_1057 3448-5381 134 µM 0.521826638521152 0.316519971701762 no 1044 0.300895520280456 309 5497911 SGTC_333 3486-0131 40.1 µM 0.520531291294506 0.316961315069731 no 1045 0.301346662091065 332 6744690 SGTC_3035 9091303 49.47 µM 0.520448163976131 0.316989646642112 no 1046 0.301375623959323 331 25237002 SGTC_841 0251-0215 91.2 µM 0.520321792866209 0.317032718681258 no 1047 0.301419654526368 349 3888614 SGTC_2805 7950783 58.44 µM 0.519617152589863 0.317272932097024 no 1048 0.301665220281166 337 1178958 YDL195W SEC31 SGTC_1063 disulfiram 1.84 µM 0.519295161928839 0.317382725056737 no 1049 0.301777463336412 335 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_421 streptovitacin 30 mM 0.517210024743959 0.318094107552061 no 1050 0.302504777402572 336 91467 include heat shock SGTC_2133 5320837 200 µM 0.517147805489739 0.318115345114737 no 1051 0.302526492091849 340 2841355 SGTC_1722 st034304 3.6505 µM 0.517007509616279 0.318163235096421 no 1052 0.302575458297944 338 4036148 YLR033W RSC58 SGTC_542 3381-0244 89.3 µM 0.516195337460454 0.318440529693521 no 1053 0.302858993210377 349 1112843 SGTC_596 1155-0152 116 µM 0.514572985516438 0.318994743135425 no 1054 0.303425723302253 336 280313 SGTC_2998 9066762 71.4286 µM 0.514213011841843 0.319117769071721 no 1055 0.303551535749856 361 4945196 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.512650280149982 0.319652084907363 no 1056 0.304097987501557 338 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1166 k206-0078 225 µM 0.510977278197551 0.320224518552616 no 1057 0.304683483633416 319 5404595 SGTC_2310 7668677 200 µM 0.509968072803565 0.320570034966654 no 1058 0.305036914826188 362 2197143 SGTC_1275 0867-0008 21.1 µM 0.509651538507892 0.320678437228817 no 1059 0.305147804972634 337 3422836 SGTC_1785 bathophenanthroline 24 µM 0.508841002699589 0.320956087964555 no 1060 0.305431838159122 325 72812 An iron chelator. SGTC_1491 4138-0063 26.5 µM 0.507763446927715 0.321325362009469 no 1061 0.305809623606944 347 23883227 SGTC_1448 4255-0083 152 µM 0.507275961823218 0.321492479274407 no 1062 0.3059806012951 364 5399660 SGTC_1274 0865-0114 173 µM 0.507275839364242 0.321492521259737 no 1063 0.305980644250963 315 870624 SGTC_2281 7943571 200 µM 0.507205501795578 0.321516637027068 no 1064 0.306005317533478 348 1244024 SGTC_1774 st048371 48.465 µM 0.506861852629332 0.321634470556716 no 1065 0.306125876762535 329 4242727 SGTC_1444 4112-3581 28 µM 0.506105812919655 0.321893771438909 no 1066 0.30639118502738 336 2877249 SGTC_29 0299-0004 12.984 µM 0.504748897572605 0.322359373694733 no 1067 0.306867606199993 324 16871 A napthoquinone isolated from Swertia calycina. SGTC_1548 st061468 90.8 µM 0.504227465409883 0.322538368406682 no 1068 0.307050771034169 346 390799 SGTC_814 3342-0569 96 µM 0.503887374087092 0.322655135481326 no 1069 0.307170261752799 344 4346283 SGTC_1952 st077036 64.1 µM 0.502827923921943 0.323018999548406 no 1070 0.307542629640446 334 2937007 SGTC_1547 harmine 94.2 µM 0.502737911253236 0.323049921865972 no 1071 0.307574275792378 340 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_144 4161-2749 112.381 µM 0.500707004864385 0.323747929871614 no 1072 0.308288670838412 331 797501 YMR168C CEP3 SGTC_1187 1391-0724 117 µM 0.498481061916136 0.324513683220207 no 1073 0.309072507073381 338 6997986 SGTC_3143 9086658 49.47 µM 0.498156117287926 0.32462553058728 no 1074 0.309187004866437 343 25236626 SGTC_3037 9091026 49.47 µM 0.498031436763804 0.324668450370288 no 1075 0.309230942333484 335 25236398 YIL048W NEO1 SGTC_3351 9150312 21.596 µM 0.498018558778948 0.32467288359561 no 1076 0.309235480696015 326 4904905 SGTC_781 4335-2806 94.4 µM 0.496814300167219 0.325087557351586 no 1077 0.309660005003586 361 845254 SGTC_2157 5649910 96.377 µM 0.495775558884947 0.325445411099052 no 1078 0.310026385374301 336 2858091 SGTC_2460 5552655 174.22 µM 0.495311543246599 0.325605319819516 no 1079 0.310190111981829 320 5401989 SGTC_3276 9139060 49.47 µM 0.495197862020533 0.325644501454805 no 1080 0.310230229821908 374 4870619 SGTC_1205 4161-2785 76 µM 0.494611865384973 0.325846502966042 no 1081 0.310437062488443 315 3498106 SGTC_2171 5739187 198.077 µM 0.49453550860364 0.325872828019149 no 1082 0.310464017702427 313 2262761 SGTC_1170 0310-0127 64.8 µM 0.494490499872248 0.32588834580652 no 1083 0.310479907010153 369 774975 SGTC_3087 9117406 49.47 µM 0.494474134349855 0.325893988268644 no 1084 0.310485684572847 301 42546093 SGTC_187 1488-2104 32.728 µM 0.493799029199394 0.326126783998603 no 1085 0.310724059421479 340 2852859 SGTC_1526 st051518 75 µM 0.490966981397726 0.327104093405424 no 1086 0.311724900531498 341 673993 SGTC_2161 5662504 8.5105 µM 0.490928285979086 0.327117455013687 no 1087 0.311738585087377 309 2859334 SGTC_5 0352-0601 109.883 µM 0.490783137168947 0.327167577173065 no 1088 0.311789918984383 336 762456 SGTC_423 5-fluorouracil 457 µM 0.489157396367861 0.327729183751063 no 1089 0.312365134523055 331 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3085 9117376 49.47 µM 0.488292583488209 0.328028089349671 no 1090 0.312671306985092 341 16480349 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.484935292877481 0.329189513577053 no 1091 0.313861123170058 318 6708561 SGTC_1013 4112-3890 241 µM 0.484872396859375 0.329211287667534 no 1092 0.31388343190836 328 705171 SGTC_648 0375-0473 33.3 µM 0.482831448976756 0.32991816129735 no 1093 0.314607709417945 357 1713139 SGTC_2293 7624732 200 µM 0.482647030605299 0.3299820637938 no 1094 0.31467318974933 338 894453 SGTC_2695 st077686 51.995 µM 0.482558064469345 0.330012893072517 no 1095 0.314704780508911 318 2876092 SGTC_1253 0550-0034 176 µM 0.480243936506004 0.330815208804254 no 1096 0.315526974231543 328 5969915 SGTC_1597 7-benzyloxygramine 47.5 µM 0.477577703856739 0.331740564654816 no 1097 0.316475401602494 343 260807 SGTC_397 arbidol 50 µM 0.477549984187385 0.331750190586671 no 1098 0.316485268348368 337 131410 A RNA synthesis inhibitor. SGTC_402 epigallocatechin gallate 10 µM 0.476485191776655 0.332120034417534 no 1099 0.316864377317147 350 65064 An antioxidant. SGTC_2924 9010168 62.78 µM 0.476456216973728 0.332130100781807 no 1100 0.316874696203971 347 2993929 SGTC_1353 1498-1206 8.11 µM 0.475903856445909 0.332322023858047 no 1101 0.317071437314845 333 6756808 SGTC_127 0180-0333 59.125 µM 0.474408525868604 0.33284181167865 no 1102 0.317604307199218 317 771601 SGTC_24 0417-1663 219 µM 0.474323128829839 0.33287150602379 no 1103 0.317634750361788 361 4329390 SGTC_2088 5278280 127.392 µM 0.474070384120518 0.332959396812655 no 1104 0.317724858466054 341 791502 SGTC_2218 6965428 192.983 µM 0.47159738979484 0.333819852590834 no 1105 0.318607095088662 338 675684 SGTC_3000 9075062 71.4286 µM 0.470727212399545 0.33412283111584 no 1106 0.31891777450931 336 17057871 SGTC_2552 juarezic acid 87.02 µM 0.470044812329588 0.334360504955312 no 1107 0.319161500852128 331 1549512 SGTC_1749 st037932 54.2 µM 0.469890868785809 0.334414131298958 no 1108 0.319216494215765 378 594497 SGTC_1827 berberine 7.24 µM 0.469398447257731 0.33458568937759 no 1109 0.319392429024338 344 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1091 telmisartan 47.6 µM 0.469011649382575 0.334720472740084 no 1110 0.319530654611961 360 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_78 0336-0123 156.75 µM 0.46864222400274 0.334849222378293 no 1111 0.319662695401306 334 6765896 SGTC_380 3970-0968 6 µM 0.465265970522364 0.336026789325586 no 1112 0.320870500431797 349 2891601 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.464858484277566 0.336169021236816 no 1113 0.321016401270022 323 6708739 YPR165W RHO1 SGTC_772 k072-0172 35.3 µM 0.464857322793227 0.336169426683145 no 1114 0.321016817180109 319 5861980 SGTC_1715 st032160 10.2275 µM 0.464490460694989 0.336297498978664 no 1115 0.321148196219123 354 5289825 SGTC_1241 0364-0022 50.8 µM 0.464291176692174 0.336367077389155 no 1116 0.321219572313911 364 4563895 SGTC_2790 5423970 71.43 µM 0.464026996027957 0.336459322587266 no 1117 0.321314202151954 355 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1407 3909-7909 12.3 µM 0.463159163854944 0.336762416864908 no 1118 0.321625142322864 343 4411780 SGTC_1996 st072960 66.8 µM 0.461263848369181 0.33742473281205 no 1119 0.322304659286267 353 1719405 SGTC_119 0121-0043 24.815 µM 0.460106052283768 0.337829571533224 no 1120 0.322720050043806 354 1092378 SGTC_2198 6589944 200 µM 0.460087192978534 0.337836167493539 no 1121 0.322726818164493 333 5290268 SGTC_2806 7952793 58.44 µM 0.459133223881837 0.338169878984861 no 1122 0.323069249768888 342 2972490 SGTC_1928 4'-methoxychalcone 40.3 µM 0.458747571347467 0.338304821653314 no 1123 0.32320772411913 390 641818 SGTC_1492 4158-0558 28.5 µM 0.45775341198676 0.338652781104962 no 1124 0.323564804957499 333 3967268 SGTC_1902 st060212 70.5 µM 0.457431919088431 0.338765334301108 no 1125 0.32368031314257 348 688944 SGTC_2314 7727897 200 µM 0.455458575006194 0.339456508162856 no 1126 0.324389681610799 327 900724 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.45528619241915 0.339516911743361 no 1127 0.324451679219303 344 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2996 9066192 71.4286 µM 0.452889484720049 0.340357154694784 no 1128 0.325314161562261 332 6472854 SGTC_1621 st003705 32.4 µM 0.451467440163144 0.34085607335798 no 1129 0.325826343373795 352 24207032 SGTC_1065 prochlorperazine maleate 2.48 µM 0.450490609015614 0.341198952082231 no 1130 0.326178362040434 368 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_3080 9117754 49.47 µM 0.449715542416761 0.341471102517957 no 1131 0.326457781479051 368 9550191 SGTC_2348 9022543 33.42 µM 0.447763360607487 0.342156940492768 no 1132 0.327161994357732 379 3162678 YDL140C RPO21 SGTC_1530 rhein 70.4 µM 0.447726043442445 0.342170055792677 no 1133 0.327175461828665 357 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_547 1120-0019 610 nM 0.447476503155665 0.342257762837962 no 1134 0.32726552473514 347 3676939 SGTC_3026 9090633 49.47 µM 0.446358635433768 0.342650769210949 no 1135 0.32766910367171 342 25236842 SGTC_122 0236-0016 402.397 µM 0.445342102007295 0.343008297634473 no 1136 0.328036273200634 370 6808838 SGTC_1657 st012939 43.4 µM 0.44485251773829 0.343180541168653 no 1137 0.328213169247029 349 24207257 SGTC_3057 9095946 49.47 µM 0.443207580462718 0.343759494755423 no 1138 0.328807798178345 357 24540043 SGTC_59 0330-0160 1.33 µM 0.44284836634932 0.343885972892095 no 1139 0.328937708346411 359 4293482 SGTC_1782 st039423 80.636 µM 0.442761211184991 0.343916662580168 no 1140 0.328969231220826 354 2068169 SGTC_1108 betulinic acid 729.144 nM 0.44214984035477 0.344131971665476 no 1141 0.329190390178095 334 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1358 1509-0022 2.48 µM 0.43948016127664 0.345072755386074 no 1142 0.330156826918032 356 3258434 SGTC_34 0469-0683 81.75 µM 0.438447462110601 0.345436931644416 no 1143 0.330530973638072 353 3690923 SGTC_3274 9138298 49.47 µM 0.43816598025742 0.345536219665857 no 1144 0.330632983863136 354 17015756 SGTC_91 0417-1751 58.384 µM 0.437161610627652 0.34589058084941 no 1145 0.330997074203091 354 6795624 SGTC_163 TUB2.036 7.546 µM 0.43469499645983 0.346761422885592 no 1146 0.331891915361181 355 15992207 YJR013W GPI14 SGTC_364 0083-0097 67.7 µM 0.433714699788585 0.347107743432242 no 1147 0.332247815349911 340 5207356 SGTC_2893 9048488 25.97 µM 0.432876651145002 0.347403911689878 no 1148 0.332552191726916 359 6467338 SGTC_153 4077-0274 519.67 µM 0.43281755586243 0.347424799613797 no 1149 0.332573659100166 371 3121976 SGTC_2768 sulfasalazine 50.2 µM 0.432747432496622 0.347449586144786 no 1150 0.332599133325826 368 5384001 An antioxidant and salicylic acid derivative. SGTC_957 1187-1561 14.1 µM 0.432688870098266 0.34747028671638 no 1151 0.332620408307048 360 1538454 SGTC_3091 9116372 49.47 µM 0.431891364834193 0.347752233248085 no 1152 0.332910185552233 340 17169793 SGTC_87 0100-0052 35.5 µM 0.429585159577094 0.348568032432141 no 1153 0.333748717153094 367 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1944 st076371 56.9 µM 0.427334595244332 0.349364824948375 no 1154 0.334567819170546 350 24208455 SGTC_835 0312-0010 67.2 µM 0.426773674792105 0.349563517455486 no 1155 0.33477209127247 357 1626196 SGTC_2858 9025781 8.96 µM 0.425888481621837 0.349877159569542 no 1156 0.335094554220124 358 4894980 YPL153C RAD53 SGTC_645 0845-0943 5.41 µM 0.425123515594561 0.350148285283456 no 1157 0.335373318121922 360 1885106 SGTC_168 3970-0862 530.542 µM 0.424887994256197 0.35023177613164 no 1158 0.335459163524762 386 3135186 SGTC_1436 4092-1007 8.32 µM 0.423781434984737 0.350624141343879 no 1159 0.335862609333068 338 2881121 SGTC_2875 9039966 71.43 µM 0.422038570360203 0.351242451653352 no 1160 0.336498432383545 394 6463691 SGTC_1915 st067105 30.6 µM 0.421640602745764 0.35138369261238 no 1161 0.336643682583767 369 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_793 0488-0545 106 µM 0.421108943331431 0.351572413570967 no 1162 0.336837765640152 371 292548 SGTC_3032 9089427 49.47 µM 0.420609094711624 0.351749876154881 no 1163 0.337020275754665 363 17173707 SGTC_2144 5628481 200 µM 0.419784762858492 0.352042611441828 no 1164 0.337321348494826 347 2818399 SGTC_2243 6634756 200 µM 0.419740787109404 0.352058230498796 no 1165 0.337337412794494 322 885676 SGTC_375 3970-0961 9.27 µM 0.41888282851241 0.352363005272334 no 1166 0.337650883555221 350 2898222 SGTC_1881 5652484 16 µM 0.418469326940307 0.352509928344551 no 1167 0.337802004118159 377 2255129 SGTC_2721 ifenprodil 61.44 µM 0.415954043601356 0.353404118170677 no 1168 0.338721816015492 363 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_518 1021-0119 62.6 µM 0.415073914192536 0.35371719798727 no 1169 0.339043897463892 365 1097762 SGTC_221 trifluoperazine 10.304 µM 0.414955593559847 0.353759294578496 no 1170 0.339087205621254 383 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1852 st056254 31.4 µM 0.413763021528606 0.354183692424539 no 1171 0.339523833905212 387 442583 SGTC_181 1447-1644 8.07 µM 0.412068185934802 0.354787141249366 no 1172 0.340144723164695 375 534600 SGTC_2963 9082507 9 µM 0.411216617675525 0.355090481137797 no 1173 0.340456852103761 369 16459611 SGTC_273 hydroxyurea 18.1 mM 0.410834775362409 0.3552265282675 no 1174 0.340596845903023 384 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2514 salinomycin 42.74 µM 0.410609112301724 0.35530693875103 no 1175 0.340679590458093 383 23682228 A polyether potassium ionophore. SGTC_1412 3909-8563 178 µM 0.408702975399338 0.355986408940493 no 1176 0.341378824991062 392 23767530 SGTC_1613 st002381 52.1 µM 0.408532650729053 0.356047145949447 no 1177 0.341441332309698 354 551167 SGTC_3082 9117008 49.47 µM 0.407156922148382 0.356537858354624 no 1178 0.341946369192954 362 41448529 SGTC_2038 4100038 30.985 µM 0.401340000122544 0.358615329706043 no 1179 0.344084908733734 367 3596803 SGTC_2937 9044753 11.33 µM 0.400697203268749 0.358845158153636 no 1180 0.344321535064206 368 6465530 YGL099W LSG1 SGTC_252 miconazole 1.30953 nM 0.399540740348864 0.359258773705645 no 1181 0.344747405535906 376 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2612 dictamnine 15.46 µM 0.398544506384457 0.359615214773055 no 1182 0.345114429101866 374 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1950 st077106 7.18 µM 0.398497726902948 0.359631954939307 no 1183 0.345131666763224 346 13831864 SGTC_16 erodoxin 22.806 µM 0.398153831426395 0.359755027148554 no 1184 0.34525839786253 380 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_3247 9135149 49.47 µM 0.39520738162221 0.360810088093887 no 1185 0.34634492272072 401 8934436 YOR116C RPO31 SGTC_827 3253-0474 693 µM 0.395180574212378 0.360819692135337 no 1186 0.346354813972048 363 5402065 SGTC_2804 7954240 19.48 µM 0.392795025906754 0.361674691120193 no 1187 0.347235439381512 359 828705 SGTC_2109 5483026 200 µM 0.389791974179707 0.362751990287962 no 1188 0.348345189488294 393 759335 SGTC_1467 k284-1082 293 µM 0.38972605845503 0.362775648777673 no 1189 0.348369562646384 383 3334705 SGTC_724 3910-0327 137 µM 0.387944204703388 0.363415390414902 no 1190 0.349028662146489 398 2885483 SGTC_740 k014-0057 261 µM 0.386849110052295 0.363808753115043 no 1191 0.34943395885688 410 4012779 SGTC_1240 0356-0016 42.1 µM 0.383015926026772 0.365186777740746 no 1192 0.350853977811213 377 4305613 SGTC_3182 9108849 49.47 µM 0.382207053753679 0.365477789518785 no 1193 0.351153895087094 354 17133045 SGTC_1076 itraconazole 331 nM 0.382083276072619 0.365522328434043 no 1194 0.35119979811418 361 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_3309 9129340 25.759 µM 0.380760164981169 0.365998536592887 no 1195 0.351690610166963 359 17158987 SGTC_2037 5169046 200 µM 0.380202995477641 0.366199132353701 no 1196 0.351897367923159 356 5718022 SGTC_2592 piperlongumine 83.33 µM 0.379251461206966 0.366541794397152 no 1197 0.352250570143176 382 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2635 hydroquinidine 100 µM 0.378522534705363 0.366804363975078 no 1198 0.352521228317487 356 442912 An experimental heart treatment. SGTC_2371 9071574 200 µM 0.378058133936533 0.366971680178479 no 1199 0.352693704227727 397 45596039 SGTC_2789 5281112 71.43 µM 0.378011103400088 0.366988625941775 no 1200 0.352711172801507 365 765948 SGTC_141 0443-0274 32.331 µM 0.377648918710821 0.367119134856431 no 1201 0.352845709629623 356 1627241 SGTC_1394 3474-0001 65.7 µM 0.375579883624965 0.367864980879254 no 1202 0.353614624103214 376 5017666 YIL048W NEO1 SGTC_2206 7254556 146.969 µM 0.375385545687504 0.367935061495735 no 1203 0.353686876566494 366 4398905 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.374980276466388 0.368081220630936 no 1204 0.353837567650842 378 6708514 SGTC_459 nigericin 15.3 µM 0.373667314678624 0.368554867447078 no 1205 0.354325922857684 401 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2572 astragaloside iv 100 µM 0.372646284752152 0.368923338897818 no 1206 0.354705859899475 357 45006101 An anti-inflammatory agent. SGTC_2665 lovastatin 100 µM 0.371774762478375 0.369237951055424 no 1207 0.355030277807808 384 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2258 7960471 200 µM 0.371164925408874 0.369458149182453 no 1208 0.355257347810824 401 2974708 SGTC_479 n-linoleoylglycine 10 µM 0.370398992375712 0.369734770637257 no 1209 0.355542612235795 388 6433346 An anti-infammatory. SGTC_2929 9013348 24.6 µM 0.369068715172693 0.370215368659582 no 1210 0.356038253528376 377 2995952 SGTC_1268 0828-0275 2.46 µM 0.368456994746756 0.370436437014483 no 1211 0.356266253108981 383 745337 SGTC_2231 micatex 6.853 µM 0.36774564497244 0.370693564023943 no 1212 0.356531451028562 398 20737 An antifungal of unknown mechanism. SGTC_86 0417-1630 471.922 µM 0.367405614396761 0.370816493092599 no 1213 0.356658242158057 379 3634867 SGTC_1052 3253-3998 198 µM 0.367003411039422 0.370961916111129 no 1214 0.356808236820331 365 5450317 SGTC_733 4069-0007 56.1 µM 0.366244940233966 0.371236203426388 no 1215 0.357091155388478 382 5717425 YNL287W SEC21 SGTC_723 4182-0001 115 µM 0.365496884196726 0.371506788504709 no 1216 0.357370266115927 397 744821 YLR208W SEC13 SGTC_3016 9080866 49.47 µM 0.365101825787894 0.371649713741776 no 1217 0.357517699033499 402 17066299 SGTC_2816 7982706 58.44 µM 0.364783148540244 0.371765018502501 no 1218 0.357636642556213 369 2981853 SGTC_3170 9103054 49.47 µM 0.364684170333984 0.371800833436857 no 1219 0.357673588129314 399 16432970 SGTC_2586 curcumin 80 µM 0.361843372800402 0.372829238338953 no 1220 0.358734539182108 372 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_646 4092-0839 27.3 µM 0.361735180438531 0.372868423328342 no 1221 0.358774967339092 408 877796 SGTC_291 SEC14.278 35.5 µM 0.361129075976072 0.373087965884891 no 1222 0.359001479178199 385 1068044 SGTC_2146 5545642 200 µM 0.3607680286576 0.373218763679546 no 1223 0.359136432446693 390 825326 SGTC_215 1287-0124 461.5 µM 0.359810483050524 0.373565727589924 no 1224 0.359494431596279 400 5560863 SGTC_1998 st075797 76.8 µM 0.356960102578593 0.374599160557112 no 1225 0.360560837095831 409 24208315 SGTC_2617 dihydrotanshinone i 20.83 µM 0.356071776206442 0.374921416442927 no 1226 0.360893406589658 363 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2279 7948423 32.93 µM 0.355722511789853 0.375048142136981 no 1227 0.36102419219078 350 1247112 SGTC_3097 9117246 49.47 µM 0.355599827108907 0.375092659754695 no 1228 0.361070136570426 360 16423892 SGTC_849 0386-0493 241 µM 0.354625176785199 0.37544638246573 no 1229 0.361435206072468 395 726119 SGTC_1188 1403-0014 4.57 µM 0.352664825080034 0.376158155486845 no 1230 0.362169866295612 382 9614867 SGTC_1321 1326-2144 215 µM 0.3515178522092 0.376574798970488 no 1231 0.362599940915378 414 3513030 SGTC_2675 theaflavin digallate 100 µM 0.34979255456747 0.377201792498737 no 1232 0.36324719354585 378 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2442 5158906 48.48 µM 0.349065808031614 0.377465997811246 no 1233 0.363519952606536 396 1893835 SGTC_2249 haloperidol 116.36 µM 0.348405595638142 0.377706064669547 no 1234 0.363767800381609 391 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3116 9124943 49.47 µM 0.347880742108625 0.377896945964999 no 1235 0.363964874295535 357 41905195 YPL160W CDC60 SGTC_125 0133-0007 11.75 µM 0.347304430659022 0.378106576071637 no 1236 0.364181311266366 428 26541 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.34687518530125 0.378262735025121 no 1237 0.36434254490386 365 641818 YHR062C RPP1 SGTC_2663 amphotericin b 100 µM 0.346867235124617 0.378265627477632 no 1238 0.36434553138493 400 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1296 1068-0102 11.9 µM 0.345799365137641 0.378654204460143 no 1239 0.364746751151968 404 767053 SGTC_3223 9129970 49.47 µM 0.343588681472565 0.379459018530454 no 1240 0.365577818968522 393 17248386 SGTC_2047 4141938 200 µM 0.342167186835681 0.379976799385156 no 1241 0.366112538790169 422 3807862 SGTC_1676 st018489 23.4 µM 0.341773727417159 0.380120155444144 no 1242 0.366260591372593 383 3696235 SGTC_349 k015-0014 24 µM 0.339916892641506 0.38079691101832 no 1243 0.36695955741495 383 2196908 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.338439991839843 0.381335453717291 no 1244 0.367515820577805 417 65057 A dermal irritant. YDR527W RBA50 SGTC_1856 st057054 55.7 µM 0.337515567573663 0.381672656314046 no 1245 0.367864139350597 413 1266018 SGTC_481 bay k-8644 50 µM 0.336562492416905 0.382020403942924 no 1246 0.368223367443588 397 2303 A calcium channel antagonist. SGTC_2228 7354201 200 µM 0.336175060786935 0.382161792987789 no 1247 0.368369429106134 419 753451 SGTC_362 0310-0100 9.03 µM 0.335543146737885 0.38239243699853 no 1248 0.368607701413875 370 790235 SGTC_2154 5570129 200 µM 0.334719086417449 0.382693275676649 no 1249 0.368918501141048 421 673366 SGTC_629 3448-6466 76.7 µM 0.333558122734846 0.383117227338103 no 1250 0.369356511610718 414 573744 SGTC_289 k017-0060 526 µM 0.333513327218497 0.3831335882244 no 1251 0.369373415546472 424 5512909 SGTC_32 0928-0142 34.1 µM 0.331351260844012 0.383923497669545 no 1252 0.370189587758395 421 2244242 SGTC_637 1181-0519 7.26 µM 0.330985565227554 0.384057152104723 no 1253 0.370327694453768 423 6252091 YGR060W ERG25 SGTC_2846 9008642 19.48 µM 0.330862508599532 0.384102129943239 no 1254 0.370374171136815 428 2992898 SGTC_293 4049-0273 38.5 µM 0.329906918582799 0.384451456152165 no 1255 0.370735147821791 397 1380311 SGTC_132 0417-1715 25.805 µM 0.327347841521439 0.385387415810079 no 1256 0.371702405755127 427 6769098 SGTC_3255 9139072 49.47 µM 0.327203796455807 0.385440118917356 no 1257 0.371756874820984 383 17646060 SGTC_2676 harmalol 100 µM 0.326170147508982 0.385818371670067 no 1258 0.372147813112679 393 5459187 A monoamine oxidase inhibitor SGTC_418 lividomycin a 100 µM 0.325952292623143 0.38589810719796 no 1259 0.372230225246836 392 72394 An antibiotic. SGTC_1859 st055998 20 µM 0.32514496497609 0.386193633497127 no 1260 0.37253567951727 397 676301 SGTC_3294 9122953 26.2835 µM 0.325000731662144 0.386246437776898 no 1261 0.372590258971283 419 16459826 SGTC_2487 5918373 44.05 µM 0.321406650071194 0.387562920632902 no 1262 0.373951122113721 449 2876279 SGTC_93 0109-0045 59.227 µM 0.320592913200268 0.387861166000442 no 1263 0.374259454405707 398 88733 SGTC_1211 1056-0033 32.3 µM 0.319950983269715 0.388096488538842 no 1264 0.374502744259451 401 6741922 SGTC_278 4092-0821 23.9 µM 0.31863374452037 0.388579498443956 no 1265 0.375002130868339 401 877900 SGTC_777 1315-0167 517 µM 0.318564956907854 0.388604726477265 no 1266 0.375028215136276 391 4221767 SGTC_1905 st060207 84.5 µM 0.318306894842166 0.388699375588759 no 1267 0.375126077385093 400 1948547 SGTC_2256 7954252 200 µM 0.317572704592697 0.388968689781341 no 1268 0.375404540825903 416 2972920 SGTC_2320 7373003 200 µM 0.316174484941971 0.389481729381904 no 1269 0.375935036595826 382 5415828 SGTC_3331 9141060 1.957 µM 0.315336892282919 0.389789154125491 no 1270 0.376252938388904 388 4906567 YPR165W RHO1 SGTC_2718 lomofungin 53.02 µM 0.315074449343803 0.389885493730153 no 1271 0.376352563857466 406 5351222 A RNA synthesis inhibitor. SGTC_2688 kanamycin b 96.69 µM 0.314093909053879 0.390245497931317 no 1272 0.376724857745435 401 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2370 9071495 200 µM 0.313895985401878 0.390318176793495 no 1273 0.37680001979265 421 21791103 SGTC_2339 9000433 200 µM 0.312452606543432 0.390848310728075 no 1274 0.377348287887861 377 2988954 SGTC_989 1501-0895 10.3 µM 0.311801351228574 0.391087574672795 no 1275 0.377595748537847 431 2830112 SGTC_2437 5741531 144.16 µM 0.311386685776505 0.391239939626376 no 1276 0.377753337178803 431 2262990 SGTC_977 1348-1378 135 µM 0.310163088037611 0.391689636419658 no 1277 0.378218469375723 426 X977 SGTC_1695 st026914 34.495 µM 0.310081339571861 0.391719685791483 no 1278 0.378249551119028 398 3289191 SGTC_1645 Cervolide 78 µM 0.310016884390571 0.391743378896023 no 1279 0.378274058304503 413 23173 A fragrance. SGTC_1297 1068-0111 14.1 µM 0.309785800748366 0.39182832631945 no 1280 0.378361925082076 404 767057 SGTC_3030 9087619 49.47 µM 0.309696190566025 0.391861268827864 no 1281 0.378395999969712 415 25236973 SGTC_285 1486-1325 46 µM 0.309374642341079 0.391979482814362 no 1282 0.378518278674911 403 22310230 SGTC_2940 9060638 45.86 µM 0.308013685346231 0.392479935334874 no 1283 0.379035959434234 388 4027022 SGTC_2513 baicalein 25.65 µM 0.307310185833941 0.392738696687909 no 1284 0.379303641699051 404 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_997 3996-0078 137 µM 0.306897450514873 0.392890531164839 no 1285 0.379460714845277 400 735687 SGTC_2423 st077119 87.2 µM 0.305896468567529 0.393258833770981 no 1286 0.379841737420182 374 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1637 st007924 17.4 µM 0.305041308462206 0.393573558197104 no 1287 0.380167345525511 399 683336 SGTC_691 1548-0686 185 µM 0.304274263363231 0.393855912844303 no 1288 0.380459475511328 425 46495133 SGTC_1895 st058434 18.3 µM 0.303933164136283 0.393981491783341 no 1289 0.3805894054473 422 5393175 SGTC_3229 9132204 49.47 µM 0.303475626493505 0.394149955946907 no 1290 0.380763709715456 410 17682924 SGTC_1324 1418-0026 34.4 µM 0.302879824942876 0.394369358202771 no 1291 0.380990723497515 400 1372513 SGTC_1845 st056753 3.01 µM 0.301423912423451 0.394905634811117 no 1292 0.38154563112049 383 5375839 SGTC_146 3448-8650 53.125 µM 0.301308749679008 0.394948062827827 no 1293 0.38158953474724 447 2891488 YIL048W NEO1 SGTC_1049 3226-0134 66 µM 0.300333954077955 0.395307244830612 no 1294 0.381961218177106 395 5702385 SGTC_261 5-fluorouridine 15.376 µM 0.297808932932455 0.39623804992914 no 1295 0.382924498128255 388 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1111 tnp00062 510.699 nM 0.295811225451483 0.396974889647281 no 1296 0.383687124895033 389 676306 SGTC_358 0075-0058 9.45 µM 0.29558886562734 0.397056928238189 no 1297 0.383772038905737 442 1069125 SGTC_1417 3966-0327 90.4 µM 0.295274100702446 0.397173067035601 no 1298 0.383892249802403 422 651118 SGTC_839 0122-0028 230 µM 0.294866231976606 0.397323571899216 no 1299 0.384048034300723 413 759448 SGTC_1912 st060209 90.8 µM 0.294849831113159 0.397329624190158 no 1300 0.384054298963873 449 688787 SGTC_553 k007-0256 45.7 µM 0.293923533903966 0.397671488972429 no 1301 0.384408167266743 405 6287000 SGTC_2397 5161689 200 µM 0.29390207091435 0.397679411164328 no 1302 0.384416367799625 402 2259942 SGTC_1161 k007-0610 110 µM 0.293180731228849 0.397945688966993 no 1303 0.384692005776663 414 5843850 SGTC_2626 ethyl orsellinate 100 µM 0.292034953646549 0.398368742921012 no 1304 0.385129949553489 404 75653 A natural product. SGTC_1833 st055984 71 µM 0.291661549151383 0.398506640410802 no 1305 0.385272705432273 405 676288 SGTC_3310 9130229 44.1445 µM 0.291594168747508 0.398531525201646 no 1306 0.385298467219906 430 7761258 SGTC_1959 st077091 55.8 µM 0.291434618059879 0.39859045177527 no 1307 0.385359470815559 409 821356 YKL052C ASK1 SGTC_231 b-estradiol 524 µM 0.289031763093734 0.399478172834963 no 1308 0.386278535469725 404 450 A steroid. SGTC_614 0462-0418 107 µM 0.288396486926597 0.399712959085561 no 1309 0.386521628288728 422 5188303 SGTC_1663 st014140 55.4 µM 0.286786932566787 0.400307982588469 no 1310 0.387137734578227 414 4207120 SGTC_1665 st014639 11.4 µM 0.286503252857889 0.400412877943157 no 1311 0.387246351213523 432 981133 YIL048W NEO1 SGTC_2821 7996764 71.43 µM 0.286314656968683 0.400482618428358 no 1312 0.387318566590035 370 2987135 SGTC_729 4092-0585 94.1 µM 0.285358465846929 0.40083625515131 no 1313 0.387684762320489 389 2169061 SGTC_593 1203-0218 61.7 µM 0.284607527807507 0.401114038286353 no 1314 0.387972421661188 432 3666956 SGTC_3103 9120822 49.47 µM 0.284267656306049 0.401239778246337 no 1315 0.388102635328999 449 17141819 SGTC_2054 5233173 129 µM 0.284004519176457 0.401337136336214 no 1316 0.388203458692299 390 6889 SGTC_2259 7964009 200 µM 0.283959375683775 0.401353839589986 no 1317 0.388220756585889 386 313134 SGTC_3228 9131799 49.47 µM 0.282642362590298 0.401841218369489 no 1318 0.388725501586615 420 17015818 SGTC_1036 k216-0215 33.5 µM 0.281881991140931 0.402122673843631 no 1319 0.389016999410178 412 622330 SGTC_489 paxilline 115 µM 0.281858510341315 0.402131366193267 no 1320 0.389026002061248 416 105008 A toxic potassium channel blocker. SGTC_2299 7976368 114.88 µM 0.281068506497437 0.402423845644322 no 1321 0.389328928015634 401 2979718 SGTC_1640 st009078 66.4 µM 0.279672467215322 0.40294082825415 no 1322 0.389864401840559 433 690618 SGTC_214 4373-3496 70 µM 0.27957651934508 0.402976366005439 no 1323 0.389901211914771 444 3779166 SGTC_455 paf C-16 10 µM 0.27912174133495 0.403144820327671 no 1324 0.390075699378961 421 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2403 6032726 181.2 µM 0.27846025989723 0.403389871747421 no 1325 0.390329533544253 397 2881040 SGTC_2332 7982454 138.89 µM 0.278321154499579 0.403441409355239 no 1326 0.390382919231203 443 2981748 SGTC_467 ro 31-8220 72.8 µM 0.276909110948407 0.40396465668801 no 1327 0.390924948266328 414 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1369 1866-0067 208 µM 0.275249866107411 0.404579726614367 no 1328 0.391562139156715 418 3531355 SGTC_1849 st056239 19.2 µM 0.274715914285664 0.404777708888483 no 1329 0.391767251793157 442 5393181 SGTC_237 nikkomycin 200 µM 0.274363983136336 0.404908213637294 no 1330 0.391902459332749 431 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_3031 9088762 49.47 µM 0.274321851228213 0.404923837896992 no 1331 0.391918646759508 411 205253 SGTC_594 1487-1584 10.8 µM 0.272513933741085 0.405594431196155 no 1332 0.392613439489655 415 5013332 SGTC_1574 spiramycin 23.7 µM 0.271595497001106 0.405935204323723 no 1333 0.392966531112928 424 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1198 1612-1005 86.7 µM 0.270935531535966 0.406180119325881 no 1334 0.393220308249926 424 6998509 SGTC_3290 9121031 71.43 µM 0.270101863940155 0.406489548140636 no 1335 0.393540944086547 419 17014854 SGTC_1929 genistein trimethyl ether 50.5 µM 0.269489506756631 0.406716871337094 no 1336 0.393776508016613 452 136420 SGTC_1003 4049-0218 100 µM 0.267399581587792 0.407492943171595 no 1337 0.394580760779286 430 295161 SGTC_2993 9054257 71.4286 µM 0.26679005951581 0.407719351361692 no 1338 0.394815404150546 443 6470217 YGL055W OLE1 SGTC_3104 9120930 49.47 µM 0.266523547608544 0.407818357431348 no 1339 0.394918013336596 435 17014836 SGTC_2471 5466956 24.79 µM 0.26565077385517 0.408142623890725 no 1340 0.395254089096706 426 724419 SGTC_1233 0325-0408 14.2 µM 0.265588154059341 0.408165891791507 no 1341 0.395278204868849 444 12874 SGTC_1862 st057513 3.81 µM 0.265183832323006 0.408316135110875 no 1342 0.395433924559453 419 5393163 SGTC_275 trichlorophene 5.69 µM 0.264905904135354 0.408419419230581 no 1343 0.395540974968406 432 62616 SGTC_2449 5812982 45.77 µM 0.264714195734452 0.408490665922686 no 1344 0.395614820445039 431 776185 SGTC_599 1935-0052 86.5 µM 0.26456274506116 0.408546953333452 no 1345 0.395673161420758 418 9557311 SGTC_1405 3909-7894 12 µM 0.264491918915984 0.408573276876996 no 1346 0.395700445471965 429 7104060 SGTC_802 4112-3352 742 µM 0.26435298332366 0.40862491546276 no 1347 0.395753968517076 392 704594 SGTC_3013 9080133 71.4286 µM 0.26420087065648 0.408681453428528 no 1348 0.395812570105155 406 17050193 SGTC_71 0417-1750 47.813 µM 0.264154105555161 0.408698835687706 no 1349 0.395830586890104 454 6811472 SGTC_109 0132-0036 33.701 µM 0.26395211034136 0.408773917950476 no 1350 0.395908410390434 453 67274 A color developer. SGTC_1936 st074407 74.3 µM 0.263820118247239 0.408822981640055 no 1351 0.395959265751869 408 809813 SGTC_82 0054-0107 293.755 µM 0.26251255465136 0.40930910216986 no 1352 0.396463153728221 410 3104697 SGTC_414 piperonyl butoxide 100 µM 0.262392325085376 0.409353807629551 no 1353 0.396509494574894 438 5794 A potent inhibitor of cytochrome P450. SGTC_2239 6685329 187.64 µM 0.261059883867402 0.409849333590974 no 1354 0.397023163612307 378 805680 SGTC_2628 lathosterol 100 µM 0.260864398591855 0.409922045388554 no 1355 0.397098540138695 403 6710616 SGTC_2286 7945697 125 µM 0.257244954937654 0.411268873968791 no 1356 0.398494841173601 423 1245733 SGTC_453 enantio-paf c16 10 µM 0.256881158617067 0.411404304094087 no 1357 0.398635257940423 453 13871343 A lipid and platelet activating factor SGTC_2817 7995342 71.43 µM 0.256793280580577 0.411437019954527 no 1358 0.398669178750478 416 18879975 SGTC_1319 1306-0155 43.7 µM 0.25605925462481 0.411710312391325 no 1359 0.398952541710613 422 3122360 SGTC_1653 st012112 65 µM 0.255994811829426 0.411734307770855 no 1360 0.39897742171596 436 720429 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.255817207451299 0.411800440757719 no 1361 0.39904599314794 424 2374 Ca(2+)-ATPase inhibitor. SGTC_2892 9047358 58.44 µM 0.255589437387024 0.411885257168367 no 1362 0.399133937653796 432 6466771 SGTC_2358 9037157 4 µM 0.254882144424158 0.412148663263874 no 1363 0.39940706379592 433 2388925 SGTC_3295 9122362 53.5725 µM 0.254692278977192 0.412219378637076 no 1364 0.399480390059785 426 4730473 SGTC_1339 1486-1321 22.7 µM 0.253564483102399 0.412639484806223 no 1365 0.399916019186175 423 3469382 SGTC_2502 avocadyne acetate 18.59 µM 0.249079613378697 0.414311093451625 no 1366 0.40164959937543 390 3952079 SGTC_1635 st007035 42.4 µM 0.248275648775605 0.414610913632639 no 1367 0.401960569362099 413 3716403 SGTC_2850 9015429 58.44 µM 0.247988573572161 0.414717983817101 no 1368 0.402071623843643 445 6457570 SGTC_499 genistein 192 µM 0.246843493260113 0.415145126373033 no 1369 0.402514674505238 450 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_429 1112-0049 25.5 µM 0.245536766418192 0.415632689516776 no 1370 0.403020421890236 387 2836170 SGTC_2867 9039098 71.43 µM 0.245014510282277 0.415827588995631 no 1371 0.403222598078445 437 6463460 SGTC_2283 7944793 200 µM 0.244942091079344 0.415854616575016 no 1372 0.403250635098473 467 2970533 SGTC_823 0417-1665 178 µM 0.244076426818514 0.416177722016385 no 1373 0.403585814592836 451 3429856 SGTC_842 0271-0008 11.1 µM 0.243739267147094 0.416303580748412 no 1374 0.403716379772618 438 1221709 SGTC_3329 9141233 27.5565 µM 0.243367613905834 0.416442325569713 no 1375 0.403860315029659 453 4909101 YNL103W MET4 SGTC_1596 piperlongumine 63 µM 0.243164566963174 0.416518131034428 no 1376 0.403938957309537 406 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2862 9027634 71.43 µM 0.241970318029026 0.416964054201862 no 1377 0.404401581337037 433 5012562 SGTC_2570 licareol 100 µM 0.24165231378721 0.417082812524461 no 1378 0.404524791289191 426 443158 SGTC_338 4055-0136 114 µM 0.241467302033886 0.417151908435438 no 1379 0.404596477990217 417 2900563 SGTC_1866 st057638 64 µM 0.241044895743745 0.417309673121203 no 1380 0.404760160204606 447 688802 SGTC_2849 9019321 12.99 µM 0.23922570766513 0.417989274198054 no 1381 0.405465284734368 425 16489627 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.238913192831578 0.418106046275755 no 1382 0.405586447679948 416 2333 A French combination drug. SGTC_2684 capsaicin 100 µM 0.238434812098726 0.418284808610132 no 1383 0.405771934855611 450 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_505 gw-5074 63.9 µM 0.23835802244136 0.418313505106616 no 1384 0.405801711221922 452 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_867 0518-0118 155 µM 0.23633727696621 0.419068818816402 no 1385 0.406585481623434 460 6848158 SGTC_3025 9087895 49.47 µM 0.234126585458775 0.419895472195936 no 1386 0.40744335361001 430 17173641 SGTC_725 1497-0963 19 µM 0.234122346603898 0.419897057589935 no 1387 0.407444998950735 457 3549977 SGTC_513 4245-1575 41.7 µM 0.232175708725027 0.420625265729623 no 1388 0.408200771962215 433 719745 SGTC_3249 9135183 49.47 µM 0.230154265093589 0.421381745147821 no 1389 0.408985949522944 430 4902779 SGTC_1817 st052116 64.4 µM 0.229100472801769 0.421776218291776 no 1390 0.409395412996553 418 4361398 SGTC_334 1502-1024 68.5 µM 0.22898771062699 0.4218184339704 no 1391 0.409439233938123 448 3296216 SGTC_3341 9147222 25.867 µM 0.225836138122168 0.422998675161858 no 1392 0.410664434456202 448 1939759 SGTC_330 1488-0319 80.1 µM 0.225827642381146 0.42300185769484 no 1393 0.410667738431658 441 6846614 SGTC_1896 st058441 89 µM 0.225256223928071 0.423215924481605 no 1394 0.410889976381913 402 688759 SGTC_223 busulfan 5 mM 0.225007039307389 0.423309282001024 no 1395 0.410986899048496 448 2478 A DNA alkylator. SGTC_116 0155-0182 31.788 µM 0.224888704431564 0.423353617908573 no 1396 0.411032928398177 423 771486 SGTC_2719 novobiocin 32.65 µM 0.223842476619474 0.42374564475789 no 1397 0.411439938448528 446 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_738 1315-0003 72.4 µM 0.221955074687497 0.4244530544641 no 1398 0.41217442810775 463 6251474 SGTC_2864 9034755 47.6 µM 0.219519981074648 0.425366101672191 no 1399 0.413122508388625 413 4930451 SGTC_497 capsazepine 133 µM 0.219158394827938 0.425501714011976 no 1400 0.413263331872003 422 2733484 A calcium channel blocker. SGTC_1708 st033234 31.827 µM 0.219082450385939 0.425530197973211 no 1401 0.413292910634878 416 674664 SGTC_2750 bromebric acid 70.15 µM 0.219026038843494 0.425551356115294 no 1402 0.413314882062757 432 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_3242 9133940 49.47 µM 0.218379312545906 0.425793937501037 no 1403 0.413566791385388 440 17248444 SGTC_392 N-ethylmaleimide 8.33 µM 0.218194236188279 0.425863363199341 no 1404 0.413638887877596 426 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1373 2887-0003 58.5 µM 0.217792451429725 0.426014088290389 no 1405 0.413795413141894 431 776948 SGTC_2836 9010338 19.48 µM 0.214133446772855 0.427387218042098 no 1406 0.415221496956131 440 2994051 SGTC_2386 9075165 157.42 µM 0.213821149532987 0.427504456113054 no 1407 0.415343265705256 444 16452277 SGTC_396 dithiazanine 1.25 µM 0.213688120134773 0.427554398012741 no 1408 0.415395138065331 438 10578 An antihelmenthic. SGTC_556 4058-0063 51.5 µM 0.213672749459895 0.42756016854668 no 1409 0.415401131671533 457 6615692 SGTC_1904 st060225 78 µM 0.213015762598224 0.427806832238861 no 1410 0.415657334027356 439 66595 SGTC_1007 4101-0031 70 µM 0.212652022806941 0.427943409364329 no 1411 0.415799195506354 454 1146276 SGTC_592 k241-0073 46.5 µM 0.212389867380356 0.42804184891653 no 1412 0.415901445061792 455 4230158 SGTC_1765 st044815 90.4 µM 0.212321643862731 0.428067467631366 no 1413 0.415928055493856 450 645695 SGTC_2172 5754775 163.918 µM 0.211015507705783 0.428557995113309 no 1414 0.416437585204985 457 2263357 SGTC_1365 1672-3266 55.4 µM 0.210315818417365 0.428820813191904 no 1415 0.41671059503429 466 6415873 SGTC_2081 5214970 32.255 µM 0.209395692712226 0.429166479875768 no 1416 0.417069677478141 436 2063512 SGTC_1555 citronellol 128 µM 0.20933686010664 0.429188583567036 no 1417 0.417092639475618 475 8842 A terpine precursor. SGTC_1148 3909-7663 27.7 µM 0.206309511437934 0.430326271073073 no 1418 0.418274574649182 446 4084526 SGTC_1446 4239-0190 62 µM 0.205177915357346 0.430751677645473 no 1419 0.418716561686237 467 1340085 SGTC_355 1311-2252 105 µM 0.204484317723151 0.431012465030326 no 1420 0.418987522867757 445 5338538 SGTC_1810 st050138 53 µM 0.20398626450606 0.431199747778666 no 1421 0.419182116289029 480 3444541 SGTC_2957 9076800 11.52 µM 0.203390656132527 0.431423734461395 no 1422 0.419414851254268 433 16459615 SGTC_1850 st056238 17 µM 0.203167972656727 0.431507483298762 no 1423 0.419501872439474 475 5393177 SGTC_2067 5224629 34.075 µM 0.202977536385468 0.43157910675526 no 1424 0.419576295049811 429 2835000 SGTC_1723 st034307 2.5525 µM 0.20258134609136 0.431728121910299 no 1425 0.419731135672335 443 867466 SGTC_2508 celastrol 40.54 µM 0.202390628433263 0.431799858130926 no 1426 0.419805677117553 420 122724 Celastrol is a natural product and antioxidant. SGTC_1489 4065-0444 182 µM 0.201849344256248 0.432003468096949 no 1427 0.420017252135963 486 2877968 SGTC_786 4544-0069 423 µM 0.201766459490477 0.432034647704593 no 1428 0.420049651847864 436 748821 YLR208W SEC13 SGTC_1603 st002045 67.8 µM 0.201195316342506 0.432249511946765 no 1429 0.420272926816449 453 5887985 SGTC_666 0272-0154 136 µM 0.200852215559107 0.432378596214563 no 1430 0.420407066331847 454 6870312 SGTC_1469 k284-2957 126 µM 0.19776057550871 0.433542083023986 no 1431 0.421616196552784 464 23884841 SGTC_2908 7930301 100 µM 0.197485249706406 0.433645725352845 no 1432 0.421723911589171 422 2223178 SGTC_1623 st003709 20.3 µM 0.195434934185324 0.434417679357062 no 1433 0.422526235164931 463 16192618 SGTC_2889 9059656 51.95 µM 0.195174799018068 0.434515639484762 no 1434 0.422628053565366 433 3949838 SGTC_873 0591-4978 488 µM 0.193791869963297 0.435036481903929 no 1435 0.423169426583488 483 3305145 SGTC_3130 9127414 49.47 µM 0.193006722168927 0.435332236587531 no 1436 0.423476851772953 467 1494646 SGTC_1283 0922-0125 16.4 µM 0.19281955148289 0.435402746630566 no 1437 0.423550145475098 450 3360884 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.192481449364883 0.43553012004301 no 1438 0.423682548743457 461 165506 SGTC_2539 epi(13)torulosol 80 µM 0.190680176544651 0.436208827051597 no 1439 0.424388085273548 445 6708597 SGTC_2416 tofa 880 nM 0.190457900351287 0.436292592230301 no 1440 0.424475164983754 403 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_754 3474-0146 171 µM 0.190150092208197 0.436408594993634 no 1441 0.424595759080533 457 24762078 SGTC_170 4197-0004 226 µM 0.188578792820743 0.437000851059488 no 1442 0.425211477724833 445 218692 SGTC_2455 5377712 9.75 µM 0.188395499082653 0.437069947579956 no 1443 0.425283313869395 424 2243908 SGTC_2036 5160441 105 µM 0.188366135264847 0.437081017081667 no 1444 0.425294822313434 452 134534 YIL048W NEO1 SGTC_2980 9014342 25.29 µM 0.188217630977982 0.43713700062639 no 1445 0.425353025981322 472 2996599 SGTC_2043 5101342 149 µM 0.186954430950044 0.437613255945645 no 1446 0.425848180874038 450 678451 SGTC_2441 5730946 39.09 µM 0.18658634274597 0.437752050661547 no 1447 0.425992487800792 433 1774275 SGTC_295 k015-0027 31 µM 0.186397410339641 0.437823294223988 no 1448 0.426066561547047 447 3887424 SGTC_960 1222-0186 7.7 µM 0.185815210673243 0.438042845607384 no 1449 0.426294837937146 461 3126296 SGTC_2556 citropten 84.59 µM 0.18507125970068 0.438323422237495 no 1450 0.426586571807374 404 2775 A potential DNA crosslinker. SGTC_3148 9097893 49.47 µM 0.182607547826972 0.439252816925881 no 1451 0.427552980809922 434 17174100 SGTC_1684 st024538 14.6195 µM 0.180899967138075 0.439897170440783 no 1452 0.428223047323223 449 6732859 SGTC_3335 9143315 29.6265 µM 0.180604196962847 0.440008795186641 no 1453 0.428339130679703 434 4899691 SGTC_1873 rapamycin 2 nM 0.180319309030146 0.44011631744323 no 1454 0.428450948855947 452 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_374 0880-0231 82.3 µM 0.179134262683727 0.44056362433026 no 1455 0.428916139689019 470 6833587 SGTC_2330 7979373 200 µM 0.178953228214482 0.440631964186243 no 1456 0.428987213617749 439 1863007 SGTC_3146 9095609 49.47 µM 0.17883577206765 0.440676304401888 no 1457 0.429033328000454 453 17173999 SGTC_3233 9132340 49.47 µM 0.178643496236051 0.440748890985074 no 1458 0.429108819382215 484 17682950 SGTC_2382 9035899 200 µM 0.177580459647851 0.441150236744022 no 1459 0.429526235780398 488 6462679 SGTC_246 cycloheximide 667 µM 0.176389950525381 0.44159978104842 no 1460 0.429993799602277 465 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_785 1270-0111 65.3 µM 0.175353081514258 0.441991371129589 no 1461 0.430401102412125 453 6741994 SGTC_2306 7482397 179.52 µM 0.174627338720911 0.442265493196824 no 1462 0.430686232730045 481 891448 SGTC_2352 9027995 87.8 µM 0.172992189817555 0.442883210367739 no 1463 0.431328783345929 465 2997347 SGTC_345 1362-0200 395 µM 0.172035388144136 0.443244729911047 no 1464 0.43170485400856 440 1419823 SGTC_3224 9130643 49.47 µM 0.170814186822436 0.443706219259402 no 1465 0.432184936775785 433 17644395 SGTC_543 3844-1095 191 µM 0.168565311695383 0.444556263644388 no 1466 0.43306928365528 469 4230703 SGTC_173 1273-0061 2.693 µM 0.168315172345066 0.444650828770552 no 1467 0.433167669168568 466 2847414 YPL266W DIM1 SGTC_1329 1447-1697 50.6 µM 0.167081593124805 0.445117229099198 no 1468 0.433652924490435 455 2840515 SGTC_788 1182-0090 188 µM 0.16649208660392 0.445340140751698 no 1469 0.433884855118359 417 5715185 SGTC_1223 0764-0573 147 µM 0.166396783589942 0.445376179555939 no 1470 0.433922352497007 457 1609797 SGTC_2878 9043973 25.97 µM 0.166039083436839 0.445511447778636 no 1471 0.434063096454481 453 6465167 SGTC_1821 st053465 65.6 µM 0.165474594693756 0.445724928265203 no 1472 0.434285222330668 445 675086 SGTC_905 2-aminofluorene 215 µM 0.164832792454052 0.445967666576305 no 1473 0.434537796209977 484 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2458 5808907 16.39 µM 0.164603192307398 0.446054509388915 no 1474 0.434628159198027 484 2731747 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.16379401361963 0.446360589697941 no 1475 0.434946652236382 473 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2880 9042983 58.44 µM 0.163513332226125 0.446466767848709 no 1476 0.435057138410982 462 6464714 SGTC_1067 clotrimazole 1.36 µM 0.163027429185544 0.446650587770875 no 1477 0.435248419104274 469 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2760 etidronate 98.04 µM 0.162804649326604 0.446734870511408 no 1478 0.435336123739492 475 3305 A chelator and antioxidant. SGTC_1308 1187-1617 41.4 µM 0.162608022741591 0.44680926086642 no 1479 0.435413534919273 488 2882570 SGTC_1172 0370-0043 85 µM 0.162311757050507 0.446921351532054 no 1480 0.435530178330319 457 376585 SGTC_2759 disulfiram 3.38 µM 0.162255269827022 0.446942723676554 no 1481 0.435552418675208 453 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.162179145313893 0.446971525904076 no 1482 0.435582391004098 435 16623 A steroid. SGTC_3293 9120939 62.045 µM 0.161036722401247 0.447403802897772 no 1483 0.436032238892418 479 934087 SGTC_202 3594-0513 34.79 µM 0.160916586481413 0.447449264304259 no 1484 0.436079549214222 457 708429 SGTC_23 0213-0011 39.996 µM 0.160613039903785 0.447564134392698 no 1485 0.436199091942646 457 627608 SGTC_192 3455-0609 60.9 µM 0.160547551821175 0.44758891739991 no 1486 0.436224883227335 456 3769639 SGTC_2623 humulene 100 µM 0.15932257019024 0.448052531391319 no 1487 0.436707369717975 449 6187145 An anti-inflammatory. SGTC_3002 9075603 71.4286 µM 0.159097113177364 0.448137866973656 no 1488 0.43679618130166 491 20105405 SGTC_1993 st073995 70.8 µM 0.15851550614737 0.448358016572225 no 1489 0.43702530149888 470 3098394 SGTC_987 1497-1013 404 µM 0.156549565729092 0.449102280692154 no 1490 0.437799926508729 493 1676435 SGTC_948 3448-0295 75.3 µM 0.156483118098704 0.449127439526049 no 1491 0.437826112560882 445 678569 SGTC_756 0508-1999 28.3 µM 0.1564484762273 0.449140555937781 no 1492 0.437839764530431 445 6753853 SGTC_796 1234-0020 70.7 µM 0.154390090592936 0.449920019381833 no 1493 0.438651083271843 451 46495034 SGTC_1771 st048882 4.1505 µM 0.154113025630447 0.450024952352989 no 1494 0.43876030900557 437 4580403 SGTC_96 0929-0093 37.281 µM 0.152559428743319 0.450613411508769 no 1495 0.439372860776731 454 6991579 SGTC_804 1595-0054 20.9 µM 0.152482075519369 0.450642713600203 no 1496 0.439403363392194 465 761523 Stimulates phospholipase C. SGTC_2180 6301957 200 µM 0.152336026464701 0.450698039018613 no 1497 0.439460955743132 470 845462 SGTC_2658 polymyxin b sulfate 77.05 µM 0.152248408221148 0.450731230490822 no 1498 0.439495507356396 462 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_684 1140-0066 328 µM 0.152070287893785 0.450798706951203 no 1499 0.439565749224869 464 6813534 SGTC_118 0083-0097 135.343 µM 0.151431619992627 0.451040662093538 no 1500 0.439817623958955 491 5207356 SGTC_769 0302-0231 76 µM 0.151394820307917 0.451054603967729 no 1501 0.439832137582491 486 571869 YER009W NTF2 SGTC_2333 9017922 200 µM 0.151359355247057 0.451068040265439 no 1502 0.439846124913138 480 3163164 SGTC_3165 9101544 49.47 µM 0.151192096386839 0.451131408735118 no 1503 0.439912092397968 488 5002184 SGTC_2564 betulinic acid 100 µM 0.151137737890615 0.451152003516048 no 1504 0.439933531940015 444 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_664 1222-0054 14.9 µM 0.150249243956813 0.451488645444306 no 1505 0.440283987879391 463 6813991 SGTC_2885 9057732 51.95 µM 0.15003679554173 0.451569145312442 no 1506 0.440367792589135 468 6471414 SGTC_1697 st025554 27.742 µM 0.149662971296701 0.451710797718912 no 1507 0.44051526184529 474 1269519 SGTC_1843 st055809 45.5 µM 0.149494475179695 0.451774647596585 no 1508 0.440581734275173 454 16413835 SGTC_1266 0828-0227 32.9 µM 0.149084015494919 0.451930192307451 no 1509 0.440743669358476 460 3913820 SGTC_1671 st016596 74.5 µM 0.148404243549186 0.452187809783054 no 1510 0.441011875644375 480 2829167 SGTC_382 3229-0966 23.2 µM 0.146927020535654 0.452747711600515 no 1511 0.441594812033262 489 5722370 SGTC_1841 st054148 70 µM 0.146849455415019 0.45277711318816 no 1512 0.441625424007246 475 675442 SGTC_318 1488-0629 67.2 µM 0.146486719000167 0.452914614332565 no 1513 0.441768586763425 471 3662576 SGTC_1347 1493-0251 600 nM 0.145419660935687 0.453319132739113 no 1514 0.442189771238927 482 3986378 SGTC_2245 6637752 200 µM 0.144528715778014 0.453656924415482 no 1515 0.44254149129042 468 681890 SGTC_970 1315-0089 19.5 µM 0.137775067632156 0.45621856606705 no 1516 0.445209094782493 482 6811083 YLR033W RSC58 SGTC_3221 9128209 49.47 µM 0.137581033260852 0.456292190229856 no 1517 0.445285773113903 490 16460723 SGTC_605 1315-0399 119 µM 0.137180269742083 0.456444260193466 no 1518 0.445444152964128 466 24020461 SGTC_1954 st077032 68.9 µM 0.13668051517657 0.45663390130602 no 1519 0.445641665805006 495 698907 SGTC_1005 4092-0690 4.4 µM 0.136296968286022 0.456779451968765 no 1520 0.44579326023875 482 1529343 SGTC_474 dl-dihydrosphingosine 5 µM 0.135817586909516 0.456961378624808 no 1521 0.4459827437748 449 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1029 k015-0030 64.7 µM 0.135311309119885 0.457153522342691 no 1522 0.446182871963862 462 2208316 SGTC_413 propylparaben 100 µM 0.135063599691653 0.457247537250073 no 1523 0.446280794825174 466 7175 A pharmaceutical preservative. SGTC_198 3454-2873 16.191 µM 0.134562499167735 0.457437730778576 no 1524 0.446478896598409 500 710957 SGTC_2799 7812892 81.82 µM 0.133179636818485 0.457962648897948 no 1525 0.447025657420736 499 20205235 SGTC_2395 5646831 180.19 µM 0.133136044791528 0.457979197110514 no 1526 0.447042894627425 484 6808628 SGTC_316 k060-0003 58.6 µM 0.131741087011145 0.458508783121439 no 1527 0.447594542995592 476 6152314 SGTC_2526 patulin 37.61 µM 0.131339089913701 0.458661412233883 no 1528 0.447753535161668 461 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2786 7743617 45.45 µM 0.130738969668037 0.45888927551224 no 1529 0.447990901785761 472 583674 SGTC_1922 5578187 25 µM 0.129413534262411 0.459392585838784 no 1530 0.448515219471775 497 1350412 SGTC_2947 9072639 7.68 µM 0.128531383282749 0.459727602980883 no 1531 0.448864231961054 461 16488146 SGTC_956 1185-0240 191 µM 0.128523780589662 0.459730490403231 no 1532 0.448867240048074 471 1416193 SGTC_340 k038-0059 454 µM 0.128140566924381 0.459876033644768 no 1533 0.449018866447053 480 23733424 SGTC_2138 5575593 77.673 µM 0.126691597563974 0.460426395698013 no 1534 0.449592248210379 494 762213 SGTC_2499 avocadenofuran 51.48 µM 0.126108861624409 0.460647757736129 no 1535 0.449822876457359 464 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1018 4259-0013 28.1 µM 0.125252186544548 0.460973202282996 no 1536 0.450161951805863 477 6801262 SGTC_952 1185-0122 232 µM 0.125091193891063 0.46103436512949 no 1537 0.450225677396779 499 678600 SGTC_2079 5212404 121 µM 0.125012823909171 0.461064139065033 no 1538 0.450256698987412 474 758462 SGTC_3259 9138485 49.47 µM 0.123570332491391 0.461612202071713 no 1539 0.450827741826805 442 17646153 SGTC_3225 9130819 49.47 µM 0.123305515995971 0.461712824919815 no 1540 0.450932586517545 492 4547121 SGTC_575 k072-0246 11.9 µM 0.122970887504727 0.461839977874521 no 1541 0.451065075685252 498 6796779 SGTC_787 4152-0075 138 µM 0.122964517620674 0.461842398356555 no 1542 0.451067597760834 498 9566539 SGTC_282 k297-0036 65.7 µM 0.122905140604536 0.461864961001748 no 1543 0.45109110743959 487 5061378 SGTC_2191 5911152 200 µM 0.122871289703485 0.461877824045082 no 1544 0.451104510409641 475 2875902 SGTC_389 tpck 16.7 µM 0.122783224463347 0.461911288245069 no 1545 0.45113937933717 449 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_210 3551-0445 56.827 µM 0.122215974126769 0.462126846016341 no 1546 0.451363987883897 486 2865180 YOR207C RET1 SGTC_3174 9107204 49.47 µM 0.122178457687985 0.462141102830796 no 1547 0.451378843449624 461 3938802 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.122164191329731 0.462146524275584 no 1548 0.451384492586378 488 5024745 SGTC_1428 4049-0204 61.7 µM 0.121831342118469 0.462273014304598 no 1549 0.451516295707574 489 X1428 SGTC_1267 0828-0272 9.49 µM 0.11864413465771 0.463484414667379 no 1550 0.452778648937698 484 745334 SGTC_159 3970-0959 50 µM 0.117387491485041 0.463962135898676 no 1551 0.453276497944549 477 6615653 SGTC_448 monastrol 171 µM 0.116734202209854 0.464210508719326 no 1552 0.453535343055002 493 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1257 0669-0121 16 µM 0.114774483231297 0.464955653881716 no 1553 0.454311937402422 489 4307855 SGTC_921 1561-0023 372 µM 0.113683099262743 0.465370684936668 no 1554 0.454744505244861 504 24050882 SGTC_1024 4507-0395 26 µM 0.112832872312243 0.465694035026048 no 1555 0.455081528207297 449 4201836 SGTC_1732 st034308 51.822 µM 0.112606202994297 0.46578024354138 no 1556 0.455171383527529 441 830119 SGTC_1868 st057644 42.7 µM 0.112354411035712 0.465876008763696 no 1557 0.455271200550521 472 688665 SGTC_1126 isoteolin 1.0172 µM 0.111284133610181 0.466283094405293 no 1558 0.455695518398087 466 133323 SGTC_2313 7726885 200 µM 0.111156780499847 0.466331536186813 no 1559 0.455746011669888 490 726423 SGTC_1153 4055-0057 267 µM 0.111139519517989 0.466338101849795 no 1560 0.455752855401098 489 882706 SGTC_500 h-89 112 µM 0.109155164464061 0.467092963471859 no 1561 0.456539710660155 487 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_3058 9093861 49.47 µM 0.108901586890007 0.467189434623463 no 1562 0.456640273988222 503 17217477 SGTC_3123 9126162 49.47 µM 0.107413739690874 0.467755510440642 no 1563 0.457230377436113 508 25239884 SGTC_1419 3993-2473 62.6 µM 0.106386264359498 0.468146468381851 no 1564 0.457637945340684 502 704026 SGTC_1354 1498-1681 81 µM 0.106187344298588 0.468222161719232 no 1565 0.457716855979881 483 5754243 SGTC_639 0833-0042 114 µM 0.105729316905786 0.46839645530149 no 1566 0.45789855959407 510 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.102849292986847 0.469492530891137 no 1567 0.459041291260458 493 5377381 SGTC_2975 9084847 53.72 µM 0.10265210659731 0.469567584371315 no 1568 0.459119543076179 473 27211724 SGTC_1171 0368-0077 21.4 µM 0.101008040361196 0.470193394007946 no 1569 0.459772038768794 488 3239779 SGTC_675 1309-0189 238 µM 0.100891812957887 0.470237638478423 no 1570 0.459818171129338 483 4246530 SGTC_636 0kpi-0074 126 µM 0.100560474838231 0.47036377150239 no 1571 0.459949687054445 499 616434 SGTC_1887 st057648 70.8 µM 0.100331178968778 0.470451061061784 no 1572 0.460040702566901 508 688672 SGTC_1367 1812-0510 76.9 µM 0.10021256463651 0.470496216348074 no 1573 0.460087785546424 493 1142582 YDR527W RBA50 SGTC_907 3448-6986 75.5 µM 0.0994782423119722 0.470775773911919 no 1574 0.460379281160237 480 590582 SGTC_2271 7849410 118.62 µM 0.0983328212880487 0.471211866044438 no 1575 0.460834008422414 503 972430 SGTC_3240 9133527 49.47 µM 0.0953283679902111 0.472355903714334 no 1576 0.462027005427585 502 17617455 SGTC_2223 6903751 107.57 µM 0.0946920253134591 0.472598240280746 no 1577 0.462279726196616 517 5598863 SGTC_2137 5261020 140 µM 0.0943716238218882 0.47272026171181 no 1578 0.462406978047445 490 763655 SGTC_1190 1486-1332 13 µM 0.0941054422598774 0.472821636018495 no 1579 0.462512698635617 516 4150046 SGTC_1500 4488-1866 171 µM 0.0935563256684084 0.473030770685072 no 1580 0.462730802224116 516 2900003 SGTC_1507 4075-3230 155 µM 0.0910423383271088 0.473988333359111 no 1581 0.463729474803149 502 659771 SGTC_2044 5102272 200 µM 0.0903172638227282 0.474264538052014 no 1582 0.464017550835394 489 592666 SGTC_1044 1222-0021 1.78 µM 0.0902797679068741 0.474278821815418 no 1583 0.464032448680404 477 4306703 SGTC_73 0327-0325 16.231 µM 0.090273797525578 0.474281096186543 no 1584 0.464034820831815 508 53298 SGTC_1776 st049249 45.9 µM 0.0899655904585109 0.474398506450018 no 1585 0.46415727937332 511 1822314 SGTC_2982 9019404 25.97 µM 0.0883281264920394 0.475022328917329 no 1586 0.464807942304213 440 22333232 SGTC_2976 9009005 19.48 µM 0.0882197632684297 0.475063614087555 no 1587 0.464851004870474 517 2993148 SGTC_2649 anisomycin 9.56 µM 0.088119927970606 0.475101650450895 no 1588 0.464890678880418 505 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_878 0828-0289 13.7 µM 0.0878491310902129 0.475204822803002 no 1589 0.4649982938592 502 745350 YLR208W SEC13 SGTC_2517 totarol 10 µM 0.0869233664100846 0.475557547356858 no 1590 0.465366213052393 488 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2387 9077560 195.08 µM 0.0861359313577859 0.475857582182914 no 1591 0.465679180331384 482 5303272 SGTC_2193 5925765 200 µM 0.0856884099114949 0.476028106509342 no 1592 0.465857057895081 491 877370 SGTC_1666 st014829 29 µM 0.0856177271699514 0.476055039982637 no 1593 0.465885152980849 493 3858230 SGTC_955 1216-0110 33 µM 0.0854902616124595 0.476103610675486 no 1594 0.465935818618068 504 3619719 SGTC_3033 9090887 49.47 µM 0.0840005469151463 0.476671291918695 no 1595 0.466527998465752 489 19325384 SGTC_1962 st076595 64.5 µM 0.0838456645586014 0.47673031522442 no 1596 0.466589570375791 498 279619 SGTC_1132 3456-3614 2.5 µM 0.0829173942470384 0.477084075547424 no 1597 0.466958611529615 481 3125502 SGTC_53 0973-0023 39.979 µM 0.0803668273274847 0.478056179152678 no 1598 0.467972754748066 507 674768 SGTC_1227 3909-8010 46.6 µM 0.0788011961435893 0.478652956913292 no 1599 0.468595376311505 516 15982272 SGTC_1741 st038134 10.228 µM 0.0778538989576903 0.479014065212877 no 1600 0.468972135674611 511 1272587 SGTC_313 3474-0040 5.03 µM 0.0776166619931453 0.479104502305137 no 1601 0.469066494005872 509 1043375 YIL048W NEO1 SGTC_2181 6316240 54.2555 µM 0.0773279904752632 0.479214548211565 no 1602 0.469181312194404 498 12779990 SGTC_3281 9140613 49.47 µM 0.0768687053101903 0.47938963785829 no 1603 0.469363996703721 505 16013766 SGTC_2068 5226020 147 µM 0.076780323533031 0.479423331400709 no 1604 0.469399152034724 502 1810509 SGTC_2131 toluylene red 5.2905 µM 0.0744980051333064 0.480293463617108 no 1605 0.470307064215489 498 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.0740771110120027 0.480453939571331 no 1606 0.470474513989145 495 6312947 SGTC_3319 9138450 16.7555 µM 0.0716551718437008 0.481377422588235 no 1607 0.471438166047259 522 2029690 SGTC_1910 st062352 60.4 µM 0.0714759943037459 0.481445746838725 no 1608 0.471509464726746 512 2245730 SGTC_2848 9016370 25.97 µM 0.0694841198433656 0.48220532767102 no 1609 0.472302136314903 527 7894410 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.0689900196719196 0.482393757794509 no 1610 0.472498781859793 521 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1072 oxiconazole 14.9 nM 0.0689718859617206 0.48240067334432 no 1611 0.472505998972197 523 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1230 0170-0365 3.77 µM 0.0684716643814072 0.482591442080806 no 1612 0.472705087835857 521 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1392 3455-1037 33.9 µM 0.068363862032594 0.482632555020692 no 1613 0.472747994210931 512 981132 SGTC_3106 9121286 49.47 µM 0.0669546653556242 0.483170001863254 no 1614 0.473308896986441 511 15943471 SGTC_1504 k297-0033 30 µM 0.0649347224725003 0.483940431398037 no 1615 0.474112987193334 500 4388117 SGTC_2122 5258151 111.688 µM 0.0643513908250609 0.484162932108015 no 1616 0.474345217127972 496 2173356 SGTC_778 3456-2434 196 µM 0.0632687445780676 0.484575899848285 no 1617 0.474776252047965 516 5539063 SGTC_2083 5306046 65.942 µM 0.0626830817430323 0.484799303711241 no 1618 0.475009434855327 521 539837 SGTC_1600 coumarin 106 71.1 µM 0.062092894254507 0.485024438351455 no 1619 0.475244427822176 530 100336 A hepatotoxic, DNA x-linker. SGTC_1835 st008666 49.2 µM 0.0609914435977823 0.485444613643289 no 1620 0.475683011695141 505 690455 SGTC_2325 6158266 200 µM 0.0605441248366112 0.485615258965774 no 1621 0.475861136872977 514 3623240 SGTC_3009 9080819 71.4286 µM 0.0604289563290786 0.485659194432199 no 1622 0.475906998488047 512 17027216 SGTC_3020 9089140 49.47 µM 0.0587563639958169 0.486297288600688 no 1623 0.476573082432476 516 17217859 SGTC_2835 9006588 71.43 µM 0.0581630631153589 0.486523641469508 no 1624 0.476809371127256 498 2345538 SGTC_1408 3909-7976 48.8 µM 0.0568671129116351 0.487018080219366 no 1625 0.477325525997971 526 24152374 SGTC_1455 4262-0120 131 µM 0.0566461152672708 0.487102398588211 no 1626 0.477413549412266 504 1529587 SGTC_2927 9011802 47.9 µM 0.0557781982638584 0.487433544972934 no 1627 0.4777592515823 513 43912568 SGTC_1917 st066507 28.5 µM 0.0556239554983129 0.487492395907538 no 1628 0.477820690158925 515 3156428 SGTC_3250 9135583 49.47 µM 0.0554400346890149 0.487562570780103 no 1629 0.477893950897941 498 7699353 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.0551541385888855 0.487671655026411 no 1630 0.478007832694486 520 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2720 fluspirilene 36.88 µM 0.0550934074098612 0.487694827251998 no 1631 0.478032024147157 508 3396 An atypical antipsychotic. SGTC_332 4112-0506 40.9 µM 0.0534366966935442 0.488326967647514 no 1632 0.478691983617279 528 2790355 SGTC_1651 st011928 86.1 µM 0.0530006234499588 0.488493362235673 no 1633 0.478865705486074 513 720198 SGTC_253 dyclonine 31.25 µM 0.0515864710148003 0.489032980887646 no 1634 0.479429099776367 518 3180 An oral anasthetic. SGTC_2085 5307070 144.047 µM 0.0508022327706225 0.489332242764098 no 1635 0.479741555841423 514 2840351 SGTC_54 0159-0055 9 µM 0.049865948185474 0.489689532708827 no 1636 0.480114606470139 520 3319099 SGTC_2351 9026858 72.31 µM 0.0497017959601023 0.489752174715538 no 1637 0.480180012630524 515 1409300 SGTC_2006 4011487 200 µM 0.0494513665283412 0.489847741388254 no 1638 0.480279796816817 520 45595294 SGTC_1820 st053765 18.6 µM 0.0480162831171259 0.490395396345182 no 1639 0.480851632762007 510 3690829 SGTC_2912 7964298 10.93 µM 0.0480070105591505 0.490398934988572 no 1640 0.480855327716322 536 2975850 SGTC_2646 retinol 96.75 µM 0.0458547887062728 0.491220297317649 no 1641 0.481712994814729 530 445354 A vitamin A analog and teratogen. SGTC_274 sirtinol 40.1 µM 0.0455949825796352 0.491319450912633 no 1642 0.481816534168229 532 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2664 lyso-paf C-16 73.48 µM 0.0451611001419076 0.491485040977675 no 1643 0.481989450092975 512 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1259 0671-0132 43 µM 0.0447576153512342 0.491639031179946 no 1644 0.482150254631596 509 X1259 SGTC_3203 9113543 49.47 µM 0.0422968614950125 0.492578205433464 no 1645 0.483131023606582 510 17018012 SGTC_1396 3511-0007 98.6 µM 0.0418474366217853 0.492749738063458 no 1646 0.483310159577471 527 X1396 SGTC_124 0136-0217 7.121 µM 0.0410614044630795 0.493049747278307 no 1647 0.483623471706997 523 3976905 SGTC_2874 9043904 71.43 µM 0.0401862663514564 0.493383770669604 no 1648 0.483972313325037 502 4463428 SGTC_354 2783-3500 4.88 µM 0.0396346104646608 0.493594329513801 no 1649 0.484192216973963 531 6740761 SGTC_2887 9044784 58.44 µM 0.0395782278803623 0.493615850008857 no 1650 0.484214692735291 534 6465546 SGTC_2106 5357045 167.29 µM 0.039112138917571 0.493793750776295 no 1651 0.484400491459375 522 668842 SGTC_2297 7971671 152.32 µM 0.0381936422357598 0.494144333918122 no 1652 0.484766644980014 527 909016 SGTC_922 1866-0035 480 µM 0.0364423229645372 0.49481281136412 no 1653 0.485464833865292 527 3156169 SGTC_2321 7390090 138.78 µM 0.0340325376626025 0.495732648299066 no 1654 0.486425602209667 528 649046 SGTC_1755 st041960 45.185 µM 0.0335802538104973 0.495905291829316 no 1655 0.486605934281757 538 2257073 SGTC_2056 5235370 200 µM 0.0334128292702303 0.495969200483781 no 1656 0.486672689548746 520 5511916 SGTC_2654 protoveratrine a 100 µM 0.0333670295350193 0.495986683001434 no 1657 0.486690950817084 538 5702278 A heart drug and vasodilator. SGTC_501 nsc-95397 161 µM 0.032965387963097 0.496139996569515 no 1658 0.486851094517562 531 262093 SGTC_2722 naftopidil 47.16 µM 0.032874138624804 0.496174828108041 no 1659 0.486887478016715 529 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1363 1636-0063 10.4 µM 0.0321221630860206 0.496461871987279 no 1660 0.487187314470982 530 6072185 SGTC_847 0342-0274 5.54 µM 0.0319110294763502 0.496542466181797 no 1661 0.48727150143503 528 18097 SGTC_1733 st037357 54.9 µM 0.0318260032649026 0.496574922537227 no 1662 0.487305404765186 535 1272339 YGL099W LSG1 SGTC_2381 9035592 200 µM 0.0309496250771281 0.496909456447362 no 1663 0.487654856885109 518 4749657 SGTC_1692 fluoroquinolonic acid 71 µM 0.0303055826317308 0.497155303806778 no 1664 0.487911672161463 534 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.0300810699033365 0.497241006276308 no 1665 0.488001198963847 536 140250 A respiratory chain inhibitor. SGTC_2661 dactinomycin 12.96 µM 0.0291505632284214 0.497596206693539 no 1666 0.488372254643763 534 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1472 k841-0093 193 µM 0.0289401230873882 0.49767653785412 no 1667 0.488456172707913 527 X1472 SGTC_1757 st041620 31.8375 µM 0.027987546818944 0.498040165224423 no 1668 0.488836041728151 523 5289815 SGTC_2702 st077768 96.8 µM 0.0279417574638251 0.498057644459117 no 1669 0.488854301896578 531 6484119 SGTC_1925 st057770 10.1 µM 0.0279107083424341 0.498069496885858 no 1670 0.488866683874734 512 5989122 SGTC_920 mycophenolic acid 780.421 nM 0.0277942524285564 0.498113951788113 no 1671 0.488913125045446 536 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1173 0443-0020 122 µM 0.0262657087438384 0.498697447177724 no 1672 0.489522702963855 531 5331295 SGTC_1522 st012842 45.6 µM 0.0261864344956857 0.49872770885189 no 1673 0.489554317938814 541 3491067 YOR116C RPO31 SGTC_550 4123-0385 25.7 µM 0.0259460008290532 0.49881949059615 no 1674 0.489650204513345 533 5731123 SGTC_682 0kpi-0099 17 µM 0.0251094626716153 0.499138826244308 no 1675 0.48998382622127 530 1714895 YML126C ERG13 SGTC_2292 7671323 168.05 µM 0.0247135683595785 0.499289953048272 no 1676 0.490141716200313 535 937504 SGTC_818 4072-2707 53.5 µM 0.0231397317017561 0.499890742732672 no 1677 0.490769406423596 534 882871 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.0229827017348486 0.499950686717642 no 1678 0.490832035660675 535 6708760 SGTC_1146 3579-1023 7 µM 0.0227243384324977 0.499950686717642 no 1679 0.490935080792507 538 X1146 SGTC_821 1114-0266 29.2 µM 0.021662901431952 0.4995454981364 no 1680 0.491358428595886 536 3123235 SGTC_1015 4130-4525 82 µM 0.021472269406476 0.499472727091073 no 1681 0.491434462084778 524 1363237 SGTC_1888 azatryptophan 97.5 µM 0.0201735078951529 0.498976944077915 no 1682 0.491952480610705 511 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1068 loratadine 26.9 µM 0.020147575177608 0.498967044659781 no 1683 0.49196282416591 533 3957 A H1 histamine antagonist. SGTC_482 fipronil 114 µM 0.019782511127403 0.498827687114684 no 1684 0.492108434626512 542 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2233 sulbentine 40.3845 µM 0.0176234844541669 0.498003515626944 no 1685 0.492969610849938 539 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_288 1315-0019 35.1 µM 0.0162623337468483 0.497483923792769 no 1686 0.493512553440446 545 6811474 SGTC_1726 st035556 14.5795 µM 0.0149757686153264 0.496992807407008 no 1687 0.494025756029585 520 5919439 SGTC_2703 st077852 53.4 µM 0.0148443251781649 0.496942632168912 no 1688 0.494078188545665 535 6281836 SGTC_2028 5153890 36.43 µM 0.0136083228868434 0.496470821743414 no 1689 0.494571232191309 537 2830968 YPR165W RHO1 SGTC_2326 6164455 177.58 µM 0.0132235497232002 0.496323945977714 no 1690 0.49472472066009 536 2888790 SGTC_2873 9040596 71.43 µM 0.0131159440296521 0.496282870777703 no 1691 0.494767645398195 544 6463863 SGTC_2601 securinine 100 µM 0.0126423173919376 0.496102078691388 no 1692 0.494956579417256 544 442872 A GABA receptor antagonist. SGTC_3131 9127911 49.47 µM 0.0121569691042888 0.495916813064386 no 1693 0.495150190483485 535 45595681 SGTC_1752 st044819 83.042 µM 0.0118205245490608 0.495788387017793 no 1694 0.495284402795425 543 441209 YML126C ERG13 SGTC_491 tetrandrine 80.3 µM 0.0117743362865254 0.495770756283394 no 1695 0.495302827963961 534 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1131 3454-3128 32.3 µM 0.0116909882611912 0.495738941145736 no 1696 0.495336076726731 542 710982 SGTC_469 w7 172 µM 0.0109056245462357 0.49543915790126 no 1697 0.495649371513121 546 45115570 A P450 inhibitor. SGTC_1614 st002383 48.6 µM 0.0109036419902105 0.495438401137785 no 1698 0.495650162391519 542 1947235 SGTC_2736 butenafine 14.65 µM 0.00970075472541584 0.494979248945531 no 1699 0.496130019485511 546 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1999 st074831 12.5 µM 0.00771429639841445 0.494221015934938 no 1700 0.496922471527297 541 17112523 SGTC_520 3584-0023 682 µM 0.00764495088625323 0.494194547048984 no 1701 0.496950135568271 539 1340790 SGTC_2603 homopterocarpin 100 µM 0.0063456150514817 0.493698600961253 no 1702 0.497468482850186 544 101795 A weak amylase inhibitor. SGTC_2926 9010726 65.15 µM 0.00467478099601895 0.493060871398657 no 1703 0.498135039001752 542 2994293 SGTC_2795 7780010 54.55 µM 0.00413453555034922 0.492854672415362 no 1704 0.498350563658494 545 953673 SGTC_2966 9084041 48.03 µM 0.00321113111946962 0.492502235107749 no 1705 0.4987189462301 544 17741380 SGTC_930 2810-3379 265 µM 0.00135123611710811 0.491792383932312 no 1706 0.499460934946121 545 1015764 SGTC_2253 7938677 135.83 µM 0.0010237590923039 0.491667401035793 no 1707 0.499591579284478 546 2301972 SGTC_2008 4012253 172 µM 0.000203103200907486 0.491354198102891 no 1708 0.49991897354643 547 603940 SGTC_576 1073-0113 22.7 µM 0.000153564858434593 0.491335291986573 no 1709 0.499938736485427 546 5439563 SGTC_2270 7924575 90.91 µM 9.32374024062707e-05 0.491312268273192 no 1710 0.499962803658119 547 1262135 SGTC_3197 9113331 49.47 µM -0.000379348454829543 0.491131908926741 no 1711 0.499848661865993 550 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_809 3998-0021 90 µM -0.000426027344863594 0.491114094327007 no 1712 0.499830039684668 548 715485 SGTC_951 1171-0579 82.7 µM -0.000692085671055982 0.491012555778497 no 1713 0.499723897786197 547 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2778 tioconazole 65.09 nM -0.00230484111887262 0.490397076195447 no 1714 0.499080502242181 550 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1248 0469-0687 58.6 µM -0.00314357834318378 0.490076995918058 no 1715 0.498745895752677 550 4017482 SGTC_145 3737-0113 38.366 µM -0.00347923028437945 0.489948905651642 no 1716 0.498611990736627 550 6849351 SGTC_912 3474-0017 2.18 µM -0.00443334137786115 0.489584806970519 no 1717 0.498231358474552 551 3360550 SGTC_2366 9070441 60.58 µM -0.00516426251073492 0.489305885746531 no 1718 0.497939766494983 554 6837235 SGTC_1243 0416-0003 5.65 µM -0.00556032712617151 0.489154748733484 no 1719 0.497781761846812 554 2141977 SGTC_7 0192-1582 4.227 µM -0.00584537388711623 0.489045976747406 no 1720 0.497668046491534 552 252616 SGTC_1451 4152-0210 104 µM -0.00603733846852194 0.488972724772928 no 1721 0.497591465055453 552 659563 SGTC_195 4234-0266 16.654 µM -0.00618958793101298 0.488914627998469 no 1722 0.497530727442783 556 2303354 SGTC_512 prima-1 270 µM -0.00682289150406741 0.488672968633389 no 1723 0.497278081222844 552 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.0081255020672027 0.488175924697994 no 1724 0.49675842934607 565 61125 An anti-inflammatory. SGTC_1027 k015-0025 8.67 µM -0.0107119082740304 0.487189071317523 no 1725 0.495726648610133 551 3598955 SGTC_3062 9077494 49.47 µM -0.0111941541389111 0.487005077020994 no 1726 0.495534271886904 550 16459633 SGTC_1753 st043925 64 µM -0.0113660210958687 0.486939504206974 no 1727 0.495465711253234 553 670181 SGTC_2338 7999974 200 µM -0.0118409047309224 0.486758322551085 no 1728 0.495276272848176 556 315925 SGTC_1470 k295-0292 231 µM -0.0118992493228922 0.486736062612367 no 1729 0.49525299836334 556 5045612 SGTC_1020 4335-0961 93.3 µM -0.0130102095207792 0.486312211139787 no 1730 0.494809823765367 567 669075 SGTC_2214 7179297 48.276 µM -0.0134228791025151 0.486154774119819 no 1731 0.494645206800575 552 769744 SGTC_2451 5856223 45.7 µM -0.014432045362531 0.485769777591059 no 1732 0.494242646773605 553 2179896 SGTC_832 4083-0019 164 µM -0.014839282196008 0.485614420636189 no 1733 0.494080200182893 556 1990758 SGTC_667 1498-1044 59 µM -0.0165655442292276 0.484955892717166 no 1734 0.493391606253363 557 6739982 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.0169801762965192 0.484797726485584 no 1735 0.493226215258359 556 165521 SGTC_1383 3049-0032 20.7 µM -0.0194392535993629 0.483859732802957 no 1736 0.492245348236732 571 712864 SGTC_1573 oleylamine 1.06 µM -0.0198065646821342 0.483719632720775 no 1737 0.492098840526318 561 5356789 An amine of the fatty acid oleic acid. SGTC_1011 4112-3381 17.4 µM -0.0210979232540223 0.483227097788608 no 1738 0.491583770765249 581 2877139 SGTC_3044 9093193 49.47 µM -0.0211953405366097 0.483189943053201 no 1739 0.491544915581001 556 25236277 SGTC_3110 9122132 49.47 µM -0.0223475319679384 0.482750510959807 no 1740 0.491085366654295 554 918317 SGTC_2730 imipramine 71.33 µM -0.0226791858021756 0.482624025996576 no 1741 0.490953089444655 568 3696 A tricyclic antidepressant. SGTC_1236 0330-0013 258 µM -0.0236090564810257 0.482269404580657 no 1742 0.490582224069299 566 4617066 SGTC_566 0958-0068 16.5 µM -0.024072450227095 0.482092687004257 no 1743 0.490397409243301 565 6815365 SGTC_1192 1488-0095 21.4 µM -0.0251773350297675 0.48167134779089 no 1744 0.489956757625544 568 915875 SGTC_2902 5787006 60.46 µM -0.0251841301934491 0.481668756571007 no 1745 0.489954047606756 556 591003 SGTC_568 1193-0097 7.48 µM -0.0254819328618999 0.481555195360091 no 1746 0.489835279648058 565 3646150 SGTC_3128 9127691 49.47 µM -0.0270404945256174 0.480960893041372 no 1747 0.489213717934071 562 41316314 SGTC_1927 st060202 13.8 µM -0.027340117561421 0.480846647211422 no 1748 0.489094229815062 563 688887 SGTC_1807 st050092 58.9 µM -0.0275923672387346 0.480750465993835 no 1749 0.488993634705186 568 5008496 SGTC_2155 5570423 76 µM -0.0276537423334054 0.480727064225015 no 1750 0.488969158924659 567 797402 SGTC_2284 7945075 39.21 µM -0.0280984143087851 0.48055751680915 no 1751 0.488791829386859 565 1245402 SGTC_2882 9058044 58.44 µM -0.0287939256008959 0.480292334815483 no 1752 0.48851447277058 570 18076804 SGTC_2777 climbazole 1.536 µM -0.0289112238809463 0.48024761261391 no 1753 0.488467697001067 560 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_537 1334-0398 209 µM -0.0292458872471163 0.480120017205116 no 1754 0.488334242069387 577 5846986 SGTC_704 1310-0270 142 µM -0.0296833747962159 0.479953221614077 no 1755 0.488159785535215 566 5718033 SGTC_193 1273-0060 1.558 µM -0.033254946456731 0.478591665549077 no 1756 0.486735640694595 575 2847393 YHR072W ERG7 SGTC_1529 apigenin 74 µM -0.0358726262794877 0.477593910272755 no 1757 0.485691961439267 564 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1942 st076330 65.2 µM -0.0360753569285205 0.477516643203716 no 1758 0.485611135928179 585 24208414 SGTC_1258 0671-0043 57.1 µM -0.0364538158902905 0.477372402774757 no 1759 0.485460251895781 570 4298767 SGTC_2949 9072542 2.23 µM -0.0364983705633462 0.477355422039377 no 1760 0.485442488973674 576 16457352 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.0365347037882135 0.477341574703537 no 1761 0.48542800377501 564 390807 SGTC_1983 st071813 46.9 µM -0.0366642177046713 0.477292214521146 no 1762 0.485376369791845 583 11838595 SGTC_189 3970-0742 2.116 µM -0.0369659204023595 0.477177231317399 no 1763 0.485256089368701 565 2891807 SGTC_708 3448-5400 146 µM -0.036972798238066 0.477174610098171 no 1764 0.485253347383662 561 3462195 SGTC_647 0140-0236 81 µM -0.0389726504482938 0.476412486664007 no 1765 0.484456096911266 573 990837 SGTC_1707 st032323 6.317 µM -0.0399296790099743 0.476047803117283 no 1766 0.484074594768453 563 3132057 YMR211W DML1 SGTC_1288 0973-0013 65.5 µM -0.0403507891102898 0.475887342013596 no 1767 0.483906731434385 572 4315430 SGTC_3173 9105693 49.47 µM -0.0410824602667159 0.475608553072766 no 1768 0.48361507873873 576 17096658 SGTC_1527 coumarin 137 µM -0.0412078044905528 0.475560794309422 no 1769 0.483565115937734 566 323 A hepatotoxic, DNA x-linker. SGTC_899 1083-0020 478 µM -0.0419794580109135 0.475266785985702 no 1770 0.483257536905874 578 767123 SGTC_302 1094-0063 18.9 µM -0.0421615249069304 0.475197418489989 no 1771 0.483184966973431 563 5440289 SGTC_171 k064-0041 9.68 µM -0.0425486443430964 0.475049928468403 no 1772 0.483030667129182 561 53325 SGTC_3160 9100216 49.47 µM -0.0429703995475352 0.474889246333545 no 1773 0.482862564894769 567 17191039 SGTC_2336 9001819 198.65 µM -0.0439844599595878 0.474502921946354 no 1774 0.482458395517438 561 2989602 SGTC_2013 4024628 200 µM -0.0448639324502589 0.474167890625502 no 1775 0.482107882808474 578 5230760 SGTC_2413 inermin 26.06 µM -0.0454801456041683 0.473933157704337 no 1776 0.481862300016835 611 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1053 3366-3204 134 µM -0.0474696878582476 0.4731753472942 no 1777 0.481069444337766 578 3632071 YPR165W RHO1 SGTC_2950 9072895 21.46 µM -0.050606962668875 0.471980567439363 no 1778 0.479819357264648 575 17332245 SGTC_3055 9094636 49.47 µM -0.0506566032390532 0.471961664636933 no 1779 0.479799578910309 572 25236176 SGTC_1906 st060206 94.7 µM -0.0513044263453117 0.471714983667292 no 1780 0.479541470519058 569 5133468 SGTC_946 3434-1334 87.4 µM -0.0513408136375154 0.471701128272957 no 1781 0.479526973195365 571 4047976 SGTC_1803 st050068 52.4 µM -0.0525248203820251 0.471250306135805 no 1782 0.479055259411469 573 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1213 1315-0166 115 µM -0.0529193405352535 0.471100096886438 no 1783 0.478898087234047 586 768401 SGTC_452 diindolylmethane 8 µM -0.0534334094272016 0.470904376929511 no 1784 0.47869329317588 576 3071 Inhibits expression of several cancer promoting factors. SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.0536163237865982 0.470834738169132 no 1785 0.478620425359039 585 688751 SGTC_1395 3486-0190 4.35 µM -0.0540428056182143 0.470672372393655 no 1786 0.478450530050461 583 6748079 SGTC_1884 5633444 25 µM -0.0541194909104637 0.470643178074436 no 1787 0.478419981751169 566 5724239 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.0545058479638029 0.470496093196394 no 1788 0.478266074758214 579 5393153 SGTC_2345 9052315 157.45 µM -0.054966889499212 0.470320581447084 no 1789 0.478082421124092 580 6469265 SGTC_3300 9124615 50.48 µM -0.0550346759135153 0.470294776638901 no 1790 0.478055419129976 583 24824903 SGTC_628 1636-0253 16 µM -0.0584088923476764 0.469010445965856 no 1791 0.47671146589882 581 4456143 SGTC_1002 4049-0206 172 µM -0.058911156595526 0.468819295971417 no 1792 0.476511435904196 569 4662749 SGTC_3054 9094397 49.47 µM -0.0602502346791804 0.468309709498743 no 1793 0.475978168432378 598 2598354 SGTC_1129 3453-1384 223 µM -0.0614607698671278 0.467849084714278 no 1794 0.47549612821227 623 1084452 SGTC_2340 7987427 183.45 µM -0.0617972931859741 0.467721040723099 no 1795 0.475362129547135 569 2239331 SGTC_1402 3909-7673 35.9 µM -0.0619970410325981 0.467645040104913 no 1796 0.47528259419214 575 5328014 SGTC_1713 st033146 12.748 µM -0.0621433237427374 0.467589382799042 no 1797 0.475224348144858 584 674619 SGTC_48 0382-0018 55 µM -0.0623577046492556 0.467507816794552 no 1798 0.475138988088141 568 762596 SGTC_2147 5545932 89.7195 µM -0.0623734139772483 0.467501839883425 no 1799 0.475132733149021 584 797404 SGTC_3141 9094609 49.47 µM -0.0626719125584357 0.467388271843089 no 1800 0.475013881971537 594 25236309 YDL196W YDL196W SGTC_2167 5876490 200 µM -0.0639458211422454 0.466903625114308 no 1801 0.474506683458483 576 686534 SGTC_1496 4469-0713 57.4 µM -0.0640521226384704 0.466863185902073 no 1802 0.474464362057443 592 746691 SGTC_669 0108-0021 26.2 µM -0.0647589513519522 0.466594302861268 no 1803 0.474182962443234 617 17201 SGTC_2905 7799065 20.05 µM -0.0652045899972305 0.466424786345364 no 1804 0.47400555330962 590 1296806 SGTC_2200 6600604 21.907 µM -0.0652880447650363 0.46639304165649 no 1805 0.47397233046575 600 2904777 SGTC_1679 SEC14.276 6.7 µM -0.0682878339166788 0.465252119470206 no 1806 0.472778254324877 604 1005053 YMR079W SEC14 SGTC_2696 st077691 74.316 µM -0.0689725974403007 0.464991720231179 no 1807 0.472505715807642 586 757133 SGTC_1239 0337-0584 35.4 µM -0.0701800887776854 0.464532576663607 no 1808 0.472025161048828 588 914301 YML130C ERO1 SGTC_3094 9117742 49.47 µM -0.0702592099067339 0.464502492824718 no 1809 0.47199367400909 581 17149698 SGTC_2017 5132927 60.65 µM -0.0712987193972029 0.464107264140064 no 1810 0.471580007205236 586 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1194 1488-0194 225 µM -0.0723831040122904 0.463695011371046 no 1811 0.471148515283157 588 1391452 SGTC_2991 9074669 71.4286 µM -0.0724775931596189 0.463659091074015 no 1812 0.471110918316484 587 17333109 SGTC_2260 7964312 200 µM -0.0729193090274898 0.463491175563287 no 1813 0.470935164232336 599 231951 SGTC_12 0849-0099 9.267 µM -0.0736547118103812 0.463211631260335 no 1814 0.470642567797383 570 6071388 SGTC_516 3992-2719 87.3 µM -0.0741464819099408 0.463024707732337 no 1815 0.470446914903899 580 5350887 YDR037W KRS1 SGTC_2704 st078022 71.1 µM -0.0766458961513993 0.462074798724036 no 1816 0.469452623232796 595 54697681 SGTC_1647 st011722 22.4 µM -0.0773160072800051 0.46182015775468 no 1817 0.46918607852811 594 2854783 SGTC_46 0329-0187a 2.197 µM -0.0777845121912505 0.461642136058279 no 1818 0.468999733299555 586 46494817 SGTC_2124 5246320 200 µM -0.0783060249857138 0.461443981556954 no 1819 0.46879231246811 605 579342 SGTC_1401 3807-4679 7.6 µM -0.0785961059162633 0.461333766267936 no 1820 0.46867694249367 571 3291456 SGTC_2452 5863136 48.41 µM -0.0787865912173223 0.461261393623346 no 1821 0.468601184775221 582 2184096 SGTC_2780 5215298 71.43 µM -0.0792076153708144 0.461101435014467 no 1822 0.468433743718018 614 2834131 SGTC_640 3381-0960 37.1 µM -0.0792716516874263 0.461077106414404 no 1823 0.468408277001211 599 1745025 SGTC_701 4424-0219 185 µM -0.0796723506649199 0.460924876654119 no 1824 0.46824892525064 601 2911779 SGTC_2803 7707263 71.43 µM -0.0800467770750418 0.460782633293478 no 1825 0.468100026288722 587 2199229 SGTC_2565 isoliquiritigenin 100 µM -0.0811953114075101 0.460346340261934 no 1826 0.467643314080692 582 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2652 actinonin 100 µM -0.0826095857324407 0.459809166378245 no 1827 0.467080989509259 580 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1945 st075991 56.6 µM -0.0827448736694398 0.459757784740061 no 1828 0.467027201580061 588 1084980 SGTC_76 0433-0009 400.328 µM -0.0840792365375474 0.459251036967318 no 1829 0.466496716511219 648 2841569 SGTC_2948 9070189 9.45 µM -0.0849169864249537 0.45893292048614 no 1830 0.466163693675102 584 6473636 YDL196W YDL196W SGTC_2060 5238662 140 µM -0.0852182138778967 0.458818542623437 no 1831 0.466043955336333 600 790130 SGTC_3306 9127676 59.7925 µM -0.0852781109434144 0.45879579975602 no 1832 0.466020146534046 589 41905287 SGTC_541 4513-1321 94 µM -0.0856851866926223 0.458641236999499 no 1833 0.465858339061418 574 747515 SGTC_3043 9092303 49.47 µM -0.0858992451023559 0.458559963581927 no 1834 0.465773255807652 592 25236084 SGTC_2541 muurolladie-3-one 83.07 µM -0.0875669078228922 0.457926847157251 no 1835 0.465110452421055 615 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_297 0986-0032 24 µM -0.0876544614788122 0.457893610962519 no 1836 0.465075657359534 585 2847425 SGTC_1 0258-0098 57.368 µM -0.0878277899644988 0.457827814700885 no 1837 0.465006774955016 562 6790032 YDR047W HEM12 SGTC_972 1319-0219 195 µM -0.0883349248216689 0.457635310704795 no 1838 0.46480524072316 578 23903702 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.0887890207738149 0.45746294824966 no 1839 0.46462479169042 583 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1038 k292-0204 154 µM -0.0891533391963897 0.457324668682154 no 1840 0.464480023786351 573 4454212 SGTC_884 0851-0618 334 µM -0.0896071564078484 0.457152426460529 no 1841 0.464299698648478 603 9642473 SGTC_1940 st075990 51.1 µM -0.0899153567070707 0.457035456409152 no 1842 0.464177238848212 606 1084979 SGTC_486 niguldipine 82 µM -0.0926489254194622 0.455998159858983 no 1843 0.463091237004102 584 1236 A calcium channel blocker. SGTC_325 2810-4341 181 µM -0.0928947547406687 0.455904890564702 no 1844 0.462993586420279 584 774970 SGTC_2968 9090663 33.37 µM -0.0929109323409192 0.455898752759754 no 1845 0.462987160283264 638 25236811 SGTC_902 1120-0002 2.07 µM -0.0931102651745432 0.455823126458424 no 1846 0.46290798121789 589 3280475 SGTC_3132 9126706 49.47 µM -0.0940527769494593 0.455465561935194 no 1847 0.46253361627975 590 850858 SGTC_2080 5212524 12.4 µM -0.0963942214406299 0.454577435349371 no 1848 0.461603740688033 588 260183 SGTC_1773 st048542 73.5835 µM -0.0985769075661336 0.45374973130416 no 1849 0.460737102896362 595 3237138 SGTC_1427 4048-4900 550 nM -0.10037898451484 0.453066510600786 no 1850 0.460021726708616 588 24132586 SGTC_1860 st056228 74.6 µM -0.102370674757556 0.452311563566256 no 1851 0.459231229756836 589 688679 SGTC_1185 1319-0113 81.3 µM -0.102627262761918 0.452214316766382 no 1852 0.45912940226271 591 4672763 SGTC_152 4469-0003 551.229 µM -0.102683213538932 0.452193111814132 no 1853 0.459107198433965 603 697280 SGTC_1581 himbacine 57.9 µM -0.103589497326127 0.451849655648713 no 1854 0.458747561370122 629 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2856 9022925 19.48 µM -0.103910543876883 0.451727996630495 no 1855 0.458620169801612 603 4944862 SGTC_1921 5740136 50 µM -0.105592755768439 0.451090605040223 no 1856 0.457952736338442 622 1774243 SGTC_1984 st072354 53.1 µM -0.106522237473821 0.450738477567503 no 1857 0.457584006415592 598 5762938 SGTC_1341 1486-1360 280 µM -0.106709254049193 0.450667632356333 no 1858 0.457509820430067 597 3976547 SGTC_1312 1218-2183 165 µM -0.107041780509926 0.450541669290968 no 1859 0.457377917046459 584 6744073 SGTC_156 3474-0145 5.642 µM -0.108229513869517 0.450091789362174 no 1860 0.456906816887858 589 2265471 SGTC_435 c-PAF 6.7 µM -0.108952425492812 0.449818002165985 no 1861 0.456620112285821 589 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_753 1322-0200 289 µM -0.11004502913851 0.449404247455769 no 1862 0.456186831828971 607 5403907 SGTC_3339 9145883 14.936 µM -0.112464516879013 0.448488215500144 no 1863 0.455227551320709 601 2030670 SGTC_3187 9109394 49.47 µM -0.112655734866953 0.448415830915266 no 1864 0.455151748109977 592 17098090 SGTC_294 k038-0071 157 µM -0.113666012041742 0.448033424253389 no 1865 0.454751278158631 599 24152826 SGTC_911 3456-4043 236 µM -0.113824113374815 0.447973584638093 no 1866 0.454688611554758 590 914281 SGTC_2798 7813637 45.45 µM -0.114198346034322 0.447831946413739 no 1867 0.454540281503184 593 956368 SGTC_1081 sertraline 6 µM -0.115108369745628 0.447487551716173 no 1868 0.454179612953357 589 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2636 apigenin dimethyl ether 100 µM -0.116416728225813 0.446992478314589 no 1869 0.453661139164545 633 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_255 tunicamycin 200.472 nM -0.11661195113398 0.446918614438329 no 1870 0.453583783354023 601 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_986 1493-0483 84 µM -0.119060409071362 0.445992381404 no 1871 0.452613748279772 598 40079 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.120126343828056 0.44558923814463 no 1872 0.452191532068724 606 803109 SGTC_1362 1611-0397 101 µM -0.120199877537479 0.445561429300585 no 1873 0.452162407391987 591 27816 SGTC_2378 9074213 121.43 µM -0.121611714157912 0.445027555601 no 1874 0.451603267898766 582 657714 SGTC_1471 k673-0312 37 µM -0.122074388383534 0.444852621020707 no 1875 0.451420052631843 597 24099884 SGTC_2192 5915882 198.485 µM -0.122689018411575 0.444620249402783 no 1876 0.451176680101283 604 2876149 SGTC_2453 5731132 22.18 µM -0.12270860872867 0.444612843253767 no 1877 0.451168923305102 622 1362040 SGTC_1554 st069299 38.7 µM -0.123316062671544 0.44438320398025 no 1878 0.450928410870237 599 24207999 SGTC_525 k781-2675 26.7 µM -0.123545449533099 0.444296492410284 no 1879 0.450837593204902 589 3651118 YDL195W SEC31 SGTC_1371 2421-0008 32.7 µM -0.123931945058042 0.444150397513186 no 1880 0.450684579710286 618 2827552 SGTC_1103 duloxetine 36.1 µM -0.123938378648682 0.444147965686927 no 1881 0.450682032715098 608 60835 A selective serotonin reuptake inhibitor. SGTC_440 fluspirilene 35.1 µM -0.125174550460391 0.443680745510051 no 1882 0.450192682273507 627 3396 An atypical antipsychotic. SGTC_812 4251-0442 148 µM -0.125671535259615 0.44349292849464 no 1883 0.44999596738236 632 5723007 SGTC_3194 9111903 49.47 µM -0.126270987971047 0.443266404415661 no 1884 0.449758710329634 618 17087251 SGTC_446 go6976 132 µM -0.126508892979589 0.443176508859684 no 1885 0.449664555012733 599 3501 A protein kinase C inhibitor. SGTC_1154 4088-0362 150 µM -0.127492517132839 0.442804864550451 no 1886 0.449275297658608 595 6618304 SGTC_416 estradiol valerate 100 µM -0.127505013566576 0.442800143325635 no 1887 0.449270352659416 612 13791 A steroid. SGTC_2409 alverine citrate 63.97 µM -0.127767768647141 0.442700874821006 no 1888 0.449166378927918 606 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_26 0302-0163 425.158 µM -0.127918236785217 0.442644029786692 no 1889 0.449106839371594 620 3100915 SGTC_700 3453-2283 142 µM -0.127952569370938 0.442631059518363 no 1890 0.449093254284454 602 565664 SGTC_2127 5253358 187.912 µM -0.128967863977882 0.442247526297235 no 1891 0.448691538629072 618 20612 SGTC_464 bw-b 70c 158 µM -0.129642520858454 0.441992700794867 no 1892 0.448424630165032 638 5353454 SGTC_892 0929-0076 29 µM -0.129968141977228 0.441869718612767 no 1893 0.448295815940879 588 5751038 SGTC_736 0958-0254 92.6 µM -0.130744912620089 0.4415763667123 no 1894 0.447988551067963 618 6812352 SGTC_395 anisomycin 6.25 µM -0.131526754678673 0.441281131921669 no 1895 0.447679311620604 633 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_549 1661-1316 519 µM -0.132522875683449 0.440905029608374 no 1896 0.447285365208088 628 2857282 SGTC_49 0717-0965 32.132 µM -0.133147243586112 0.440669316109116 no 1897 0.447038466378346 672 5889349 YGL099W LSG1 SGTC_2944 9067346 25.62 µM -0.133566513848903 0.440511043562036 no 1898 0.446872682473606 626 6473075 SGTC_2666 tannic acid 100 µM -0.133570719043277 0.440509456169086 no 1899 0.446871019742166 605 16134267 A thiamine antagonist. SGTC_1278 0874-0585 172 µM -0.134719360452146 0.440075898472354 no 1900 0.446416882655102 606 766306 SGTC_1652 st011932 78 µM -0.135682066431057 0.439712577907281 no 1901 0.446036312757509 609 1551076 SGTC_2854 9024559 71.43 µM -0.136992319542047 0.439218176366399 no 1902 0.445518432996596 636 3163529 SGTC_1607 st000305 50.6 µM -0.137604569626038 0.438987186748933 no 1903 0.445276471924757 632 5457690 SGTC_1567 st069303 68.4 µM -0.138367454669494 0.43869939467878 no 1904 0.444975008490536 616 5581319 SGTC_1102 cgs 12066b 26.1 µM -0.138811455662486 0.438531913887571 no 1905 0.44479957065984 594 6438352 A 5-HT1B full agonist. SGTC_2839 9003951 25.97 µM -0.138914860932149 0.43849291015667 no 1906 0.444758713752284 601 2990634 SGTC_2594 a-mangostin 100 µM -0.140466515860991 0.437907708919033 no 1907 0.444145703316088 620 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.140580148550876 0.437864858067009 no 1908 0.444100815819175 609 4330530 SGTC_2115 tiliquinol 12.7705 µM -0.14133927455881 0.437578610602418 no 1909 0.443800962204318 633 71208 A bioactive hydroxyquinoline. SGTC_2034 5197015 53.07 µM -0.143996861775244 0.436576759134786 no 1910 0.442751473875679 640 780676 SGTC_484 loperamide 105 µM -0.144628663982972 0.436338643303323 no 1911 0.442502032293939 598 3955 An opioid-receptor agonist. SGTC_1626 st003712 1.76 µM -0.144904366536126 0.436234742783049 no 1912 0.442393189414384 647 24207035 SGTC_872 0588-0139 234 µM -0.14756368220299 0.435232787193678 no 1913 0.441343559326245 598 2047100 SGTC_978 1416-0512 87.4 µM -0.148456009069182 0.434896676272425 no 1914 0.440991450432664 619 6814003 SGTC_263 alizarin 107.927 µM -0.149118623707544 0.434647121003394 no 1915 0.440730015298958 610 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_975 1335-0046 28.5 µM -0.149595166281107 0.434467660662585 no 1916 0.440542011008902 635 16486740 SGTC_331 k048-0133 24.5 µM -0.150551802334943 0.434107443547891 no 1917 0.440164642033175 606 6813582 SGTC_1420 4'-methoxyflavone 42 µM -0.151361616197846 0.433802554431409 no 1918 0.439845233197603 613 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1177 0983-0204 23.6 µM -0.151972230833404 0.433572688429135 no 1919 0.439604418903412 609 766818 SGTC_3186 9110464 49.47 µM -0.152092251141805 0.433527509399454 no 1920 0.439557087900655 623 17018021 SGTC_2012 4023501 200 µM -0.152283388907512 0.433455561545978 no 1921 0.439481712923385 629 3477460 SGTC_2906 7926292 26.41 µM -0.152498490269307 0.433374595981102 no 1922 0.439396890551032 652 2966319 SGTC_1510 1123-0200 71.5 µM -0.153051588066632 0.433166419185156 no 1923 0.439178796546645 660 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_745 0469-0705 296 µM -0.154174100398233 0.432743981312271 no 1924 0.43873623144855 638 3486736 SGTC_1482 3346-2049 8.48 µM -0.154617869363425 0.432576997798604 no 1925 0.438561290850419 626 3826804 SGTC_609 0986-0026 86.3 µM -0.154810487755778 0.432504522172147 no 1926 0.438485361431021 623 2848610 SGTC_88 0180-0332 8.668 µM -0.155007202946476 0.432430507406263 no 1927 0.438407819406584 605 3101745 SGTC_432 NS 1619 61.3 µM -0.155322918379717 0.432311723347964 no 1928 0.438283374307819 614 4552 A K+/calcium channel activator. SGTC_2066 5222451 176 µM -0.157725451374635 0.431408000962008 no 1929 0.437336572112526 638 2281147 SGTC_642 0335-0876 158 µM -0.157864583735626 0.431355676718256 no 1930 0.43728175307413 604 6812350 SGTC_1250 0485-0349 40.2 µM -0.157966554170371 0.431317328921775 no 1931 0.437241576836435 646 6842794 YDL195W SEC31 SGTC_1112 tnp00069 1.16933 µM -0.159175485133641 0.430862738353756 no 1932 0.436765308813129 633 145826 SGTC_341 1486-1430 230 µM -0.160245729481059 0.430460374093776 no 1933 0.436343753944058 626 2054753 YPL210C SRP72 SGTC_2337 9009472 200 µM -0.160700413396033 0.430289454995052 no 1934 0.436164681911709 620 5742383 SGTC_352 k048-0007 5.11 µM -0.161343528232042 0.43004772560576 no 1935 0.435911420876927 660 6811911 SGTC_730 1436-0052 41.2 µM -0.161897520397054 0.429839516022205 no 1936 0.435693277748129 610 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2582 agaric acid 100 µM -0.161979423592132 0.429808735598139 no 1937 0.435661028735256 620 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_379 3970-0972 5.9 µM -0.163427709958283 0.429264518944617 no 1938 0.435090843389217 618 2898042 YBL034C STU1 SGTC_659 k018-0002 107 µM -0.163530262703964 0.429225988202203 no 1939 0.435050473829237 633 6797879 YHR007C ERG11 SGTC_361 000s-0510 1.45 µM -0.165915526424174 0.428329996632606 no 1940 0.434111714264441 629 660 SGTC_64 000l-0018 272.079 µM -0.166139772202735 0.42824578070629 no 1941 0.43402347769023 619 6811119 SGTC_2811 7967822 32.47 µM -0.167123299369937 0.427876453865408 no 1942 0.433636516790484 615 2232244 SGTC_665 3914-0008 307 µM -0.167669851954662 0.427671243773881 no 1943 0.43342150751439 648 1069549 SGTC_2974 9094440 9.66 µM -0.168162444812038 0.427486310306351 no 1944 0.43322774242881 627 25236134 SGTC_317 4495-0002 170 µM -0.168282253286061 0.427441333180802 no 1945 0.433180617294078 634 15991618 SGTC_767 0929-0023 86 µM -0.16851579502243 0.427353662327369 no 1946 0.433088759363327 613 1204563 SGTC_1525 8-methoxypsoralen 92.5 µM -0.168599726212696 0.427322155691382 no 1947 0.433055747964962 672 4114 Related to psoralen; DNA damaging agent. SGTC_1441 4106-0040 13 µM -0.169181562671877 0.427103754893403 no 1948 0.432826915798233 606 2904180 SGTC_276 colchicine 750 µM -0.169352337469863 0.427039656321338 no 1949 0.432759755549679 623 2833 A microtubule depolymerizer. SGTC_2365 9042475 200 µM -0.170209620966092 0.426717912878575 no 1950 0.432422642844481 620 6464479 SGTC_1203 3992-3522 103 µM -0.172025454010222 0.426036581515217 no 1951 0.431708758942752 686 5322312 SGTC_2737 bleomycin 30.5 nM -0.173787502271477 0.425375642103054 no 1952 0.431016233337571 613 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1150 3909-7983 10.9 µM -0.175290873307009 0.424811897471276 no 1953 0.430425541394827 620 23965914 SGTC_770 0389-1121 67.2 µM -0.175484523286363 0.424739292394776 no 1954 0.430349465356664 618 6753108 SGTC_1991 st073000 8.92 µM -0.176692986614728 0.424286261703993 no 1955 0.429874775034561 644 4301969 YIL048W NEO1 SGTC_633 0437-0093 97.7 µM -0.177484175933669 0.423989713508946 no 1956 0.429564046845734 625 2831118 SGTC_1680 diphenhydramine 100 µM -0.179249809580928 0.423328086141459 no 1957 0.42887077731219 615 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2844 9010103 25.97 µM -0.180587041573424 0.422827135392626 no 1958 0.428345863987036 685 2480525 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.181711436918611 0.422406013540958 no 1959 0.427904595020219 681 688798 SGTC_2188 6126565 140.678 µM -0.182066052537876 0.42227321707438 no 1960 0.42776544478975 653 874518 SGTC_2084 5306078 60.6385 µM -0.183762475578909 0.421638063016207 no 1961 0.427099897458451 654 679340 SGTC_710 3448-4187 58 µM -0.187140224610324 0.420374015821556 no 1962 0.425775345276084 624 3946412 SGTC_2621 lithochol-11-enic acid 100 µM -0.187490901274412 0.420242829712055 no 1963 0.425637878464761 664 6708711 SGTC_3038 9091290 49.47 µM -0.187766321705542 0.420139802734544 no 1964 0.42552991876723 629 25236843 SGTC_1050 3232-1156 69.3 µM -0.188031027586692 0.420040788923199 no 1965 0.42542616423574 624 700529 SGTC_1781 st038725 66.3 µM -0.188865064358899 0.419728848772681 no 1966 0.42509928767858 615 4270275 YIL048W NEO1 SGTC_1337 1486-1011 40.3 µM -0.188945908083645 0.419698614889719 no 1967 0.425067606055723 622 X1337 SGTC_3007 9078383 71.4286 µM -0.18960473283712 0.419452245728156 no 1968 0.424809439111299 642 6496995 SGTC_1040 k898-0338 155 µM -0.190091355133858 0.419270292372411 no 1969 0.424618772088951 624 20969351 SGTC_1196 1588-0294 184 µM -0.191285205415766 0.41882397200444 no 1970 0.42415107572354 659 6144269 SGTC_3212 9128307 49.47 µM -0.192789633381421 0.418261691140235 no 1971 0.423561861275106 675 27243542 SGTC_1416 3966-0321 25.3 µM -0.192867636368418 0.418232542020651 no 1972 0.423531315782105 646 582530 YLR208W SEC13 SGTC_228 caffeine 993.056 µM -0.194924988094366 0.4174638880203 no 1973 0.422725835863534 636 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2373 9071805 200 µM -0.195152593393321 0.417378870965942 no 1974 0.422636745214164 683 10149009 SGTC_1867 st057372 64 µM -0.1952428599956 0.4173451548914 no 1975 0.422601413607746 641 688837 SGTC_3307 9126885 69.2785 µM -0.196010935339807 0.417058290609622 no 1976 0.422300803430141 650 24824909 SGTC_1090 efavirenz 20.7 µM -0.197052820238717 0.416669233278346 no 1977 0.42189310172656 629 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2555 cholic acid 100 µM -0.197644292119454 0.416448404028311 no 1978 0.421661689102167 635 6708657 Influences liver metabolism. SGTC_2055 5235184 200 µM -0.199294250502563 0.415832522659042 no 1979 0.421016288200797 661 2836034 SGTC_2772 vinpocetine 57.06 µM -0.199549743645906 0.415737172956796 no 1980 0.420916367940509 624 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1231 0242-0792 125 µM -0.201156119272427 0.415137789565921 no 1981 0.420288250929943 659 3707635 SGTC_3237 9133362 49.47 µM -0.201304323650364 0.415082500321622 no 1982 0.420230310992187 676 43845137 SGTC_3152 9099253 49.47 µM -0.20494205495579 0.413725935205 no 1983 0.418808698702561 641 25236131 SGTC_2531 methyl deoxycholate 70.07 µM -0.205698984422585 0.413443793534354 no 1984 0.418513025954903 660 16667744 Haematoxylin. SGTC_1390 3413-2614 145 µM -0.206789220728841 0.413037491979186 no 1985 0.418087237409429 672 3421432 SGTC_3289 9119912 71.43 µM -0.208558652868524 0.412378270934896 no 1986 0.417396395467797 700 17014829 SGTC_1738 st035555 74 µM -0.209373050163198 0.41207494136112 no 1987 0.41707851468973 681 5331140 SGTC_1721 st082152 9.2685 µM -0.210008478514715 0.411838306842168 no 1988 0.416830527849002 637 5296051 SGTC_2372 9071633 200 µM -0.210497224916804 0.411656318718794 no 1989 0.416639808670546 611 21321366 SGTC_2393 9031399 185.94 µM -0.210839183568811 0.411528999332282 no 1990 0.416506380838842 671 1526623 YDL150W RPC53 SGTC_2204 7233102 200 µM -0.211090012359795 0.411435615694782 no 1991 0.416408516812173 655 2172480 SGTC_2723 salbutamol 83.58 µM -0.211680160428642 0.411215923181414 no 1992 0.416178283523116 660 9884233 β2-adrenoceptor agonist SGTC_726 3448-4391 34.2 µM -0.211983848268287 0.411102881136204 no 1993 0.416059817594777 674 1356692 SGTC_2053 5265679 138 µM -0.21476118484927 0.410069413774077 no 1994 0.414976758373994 619 764595 SGTC_1933 st074711 15.9 µM -0.214988788301941 0.409984748437854 no 1995 0.414888029912913 629 17250958 SGTC_1221 2958-7315 257 µM -0.215328920856144 0.409858231654756 no 1996 0.414755441432034 654 4562705 SGTC_442 cape 100 µM -0.215823774502973 0.409674181085147 no 1997 0.414562557825485 653 5281787 SGTC_22 0964-0034 14.468 µM -0.217750599177291 0.40895772851483 no 1998 0.413811718517825 644 138402 SGTC_3244 9134489 49.47 µM -0.218438769802354 0.40870191911722 no 1999 0.413543630430373 680 16584271 SGTC_2033 5192550 145 µM -0.21856781259056 0.408653955168751 no 2000 0.413493364191173 624 182073 SGTC_674 0498-0004 451 µM -0.219729502627113 0.408222227967529 no 2001 0.413040913178464 648 4231473 SGTC_353 1988-1175 58.3 µM -0.220625064507963 0.407889479885059 no 2002 0.412692191633599 657 2788357 SGTC_2097 5376186 200 µM -0.220701909925388 0.40786093088411 no 2003 0.412662272113385 641 742755 SGTC_2276 7947513 42.08 µM -0.220890551921333 0.407790850178476 no 2004 0.412588827101028 675 2105100 SGTC_3101 9120531 49.47 µM -0.221312837510072 0.407633981322926 no 2005 0.412424427457264 707 24824904 SGTC_2788 5282734 71.43 µM -0.221618662093415 0.407520384150976 no 2006 0.412305376739209 683 743706 SGTC_441 propafenone 146 µM -0.221797837071697 0.407453834019551 no 2007 0.412235631647238 632 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_869 0564-0080 44.1 µM -0.222829548678171 0.407070682187683 no 2008 0.411834084806268 646 6843321 SGTC_3346 9158254 43.5805 µM -0.223241834661544 0.406917594351664 no 2009 0.411673647019967 644 17639500 SGTC_2114 5491910 81.25 µM -0.223511018868449 0.406817649977471 no 2010 0.411568904109166 665 2849228 SGTC_1457 k015-0032 57.3 µM -0.223619737887956 0.406777285828787 no 2011 0.411526601977516 635 4302660 SGTC_2765 myclobutanil 7.74 µM -0.22387262146229 0.406683401486477 no 2012 0.411428209978482 677 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2433 5607874 27.82 µM -0.226189640996011 0.405823446278221 no 2013 0.41052696356921 632 2252428 SGTC_378 3970-0959 8.33 µM -0.226229546999917 0.405808639245889 no 2014 0.410511445534722 681 6615653 SGTC_2356 9061756 188.97 µM -0.227524657031882 0.405328164873325 no 2015 0.41000789920257 632 20104043 SGTC_1783 st039459 87.517 µM -0.228718488608617 0.404885390232892 no 2016 0.409543861914833 697 729761 SGTC_747 3448-8087 38.7 µM -0.22895113045963 0.404799120935152 no 2017 0.409453449740469 683 5168703 SGTC_407 eburnamonine 100 µM -0.229127001495016 0.40473390671755 no 2018 0.409385103743715 653 3195 SGTC_2769 toremifene 3.73 µM -0.231677440799851 0.403788484175867 no 2019 0.408394277169604 644 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_530 4358-1714 28 µM -0.231699859366591 0.403780176318588 no 2020 0.408385570310313 630 1564641 SGTC_1766 st045414 44.774 µM -0.23371103658504 0.403035052683672 no 2021 0.407604659530391 643 253960 SGTC_692 k241-0027 77.8 µM -0.234879421775136 0.402602337607601 no 2022 0.407151160931098 651 3600480 SGTC_230 MPP+ 141.667 µM -0.236694612113473 0.401930313051556 no 2023 0.406446857559242 673 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1411 3909-8223 150 µM -0.239484425363589 0.400898026718806 no 2024 0.40536498595349 664 X1411 SGTC_3291 9121177 71.43 µM -0.23958438736048 0.40086105158536 no 2025 0.405326234696909 669 17015612 SGTC_3166 9102297 49.47 µM -0.239949988922437 0.400725826093706 no 2026 0.405184513543137 660 25237072 SGTC_2457 5731572 11.68 µM -0.24022131238703 0.400625479044811 no 2027 0.405079346222735 678 2865357 SGTC_527 4476-4215 268 µM -0.24076736160645 0.400423546520438 no 2028 0.404867713610719 633 4418754 SGTC_1772 st048439 82.2 µM -0.241083260750104 0.400306737127209 no 2029 0.404745293096351 637 2927068 YDL195W SEC31 SGTC_188 3229-0966 278.469 µM -0.241351385098797 0.400207600319857 no 2030 0.404641394080488 652 5722370 SGTC_18 0111-0177 500 nM -0.241472719810566 0.400162739905306 no 2031 0.404594378712989 676 721752 SGTC_845 0330-0138 4.51 µM -0.241952212587898 0.399985472576736 no 2032 0.404408595990744 664 9039800 SGTC_2606 farnesol 9.78 µM -0.24221667427619 0.39988771054055 no 2033 0.404306137738523 641 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2466 5983409 37.09 µM -0.244852681266268 0.398913616866311 no 2034 0.403285250701804 667 2879657 SGTC_1279 0874-0590 65.2 µM -0.246024538363608 0.39848077774309 no 2035 0.402831618659674 650 3523074 SGTC_3308 9128332 17.569 µM -0.249308865512357 0.397268340047331 no 2036 0.401560937055242 655 17332805 YDL196W YDL196W SGTC_2640 pentamidine 10.38 µM -0.249604586676849 0.397159220538152 no 2037 0.401446575595389 671 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3338 9144300 39.5675 µM -0.251035532427727 0.396631323161236 no 2038 0.400893318839787 668 4901274 SGTC_52 0329-0193 875 nM -0.251060743901552 0.396622023965094 no 2039 0.400883572926136 662 3739292 SGTC_2921 7974240 10.71 µM -0.251257131274153 0.396549588932032 no 2040 0.400807658240002 687 2979074 YDR527W RBA50 SGTC_2657 nystatin 74.44 µM -0.252052790649028 0.3962561564528 no 2041 0.400500129820031 660 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_410 α-linolenic acid 100 µM -0.252880432706583 0.395950991382194 no 2042 0.400180305287888 681 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3118 9124250 49.47 µM -0.255666989541862 0.394924012343084 no 2043 0.399103993345974 669 1504786 SGTC_2094 5332512 191.667 µM -0.256176875715078 0.394736173737379 no 2044 0.398907131744766 689 755774 SGTC_925 2064-1272 59.6 µM -0.259029840342117 0.393685613559659 no 2045 0.397806108380171 680 6815817 SGTC_2988 9073640 71.4286 µM -0.259093296172374 0.39366225569382 no 2046 0.397781628560385 686 9102229 SGTC_1294 1000-1494 117 µM -0.260055726328619 0.393308035526771 no 2047 0.397410394235778 645 712797 YDL207W GLE1 SGTC_1646 st011709 75.6 µM -0.260356048312074 0.393197520785407 no 2048 0.397294571244469 646 5757843 SGTC_1975 st070967 30.8 µM -0.261103225388493 0.392922606305823 no 2049 0.39700645221818 670 261391 SGTC_2123 5259487 200 µM -0.262373726288905 0.392455264025659 no 2050 0.396516663357954 658 2173474 SGTC_322 k048-0136 19.3 µM -0.263083321356957 0.392194313324898 no 2051 0.396243179448186 647 6823282 SGTC_2815 7968870 71.43 µM -0.264168946405709 0.391795172976322 no 2052 0.395824869260231 686 2977326 YHR190W ERG9 SGTC_3001 9076041 71.4286 µM -0.264581951959062 0.391643357441732 no 2053 0.395665762518223 666 16004211 SGTC_439 amiodarone 34.4 µM -0.265129358674433 0.391442163199114 no 2054 0.395454905711831 666 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.267127606384255 0.390707972707513 no 2055 0.394685456416569 682 688669 SGTC_1418 3966-3099 2.4 µM -0.267677887984174 0.3905058580873 no 2056 0.394473635859457 666 740335 SGTC_1642 st009582 77.7 µM -0.267859286949468 0.3904392379847 no 2057 0.394403816572365 690 6739311 SGTC_2374 9071832 200 µM -0.268562708628479 0.390180931643233 no 2058 0.394133106225674 682 17381698 SGTC_2015 5119600 184 µM -0.269890746733775 0.389693389601429 no 2059 0.393622153073869 695 2828786 SGTC_853 0419-0306 21 µM -0.270160733300576 0.389594294818406 no 2060 0.393518300044656 661 762713 SGTC_571 k831-0106 44.2 µM -0.270282342268091 0.389549662296531 no 2061 0.393471524414726 691 4783639 SGTC_1844 rapamycin 4 nM -0.272242094009947 0.388830601963694 no 2062 0.392717938671444 684 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_751 0833-0568 350 µM -0.274020003224946 0.388178591440214 no 2063 0.392034624723196 676 6954252 SGTC_366 0181-0206 4.31 µM -0.274210984030593 0.388108571983651 no 2064 0.391961243745508 681 274874 SGTC_2190 6049624 200 µM -0.275076578941045 0.387791263810483 no 2065 0.391628702512032 657 2265554 SGTC_268 camptothecin 39.6153 µM -0.276506393334685 0.387267289279318 no 2066 0.391079574912438 676 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1323 1348-1351 11.2 µM -0.277160684999239 0.387027583799659 no 2067 0.390828363147503 673 6989654 SGTC_2954 9074818 52.69 µM -0.277518123665285 0.386896651204442 no 2068 0.390691145727773 705 16648742 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.278414098239182 0.386568505265976 no 2069 0.390347249175595 686 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3207 9114163 49.47 µM -0.280953912652994 0.385638753166124 no 2070 0.389372874468205 735 849233 SGTC_1237 0330-0133 46.1 µM -0.281175797691241 0.385557558630306 no 2071 0.389287783394307 706 X1237 YHR072W ERG7 SGTC_3027 9089541 49.47 µM -0.281808493936646 0.385326063232179 no 2072 0.38904517878905 675 9943819 SGTC_1779 st039427 55 µM -0.281852869519095 0.385309828310982 no 2073 0.389028164788388 712 1124498 SGTC_861 0443-0273 110 µM -0.282139344353964 0.385205025592597 no 2074 0.38891833286178 674 6149169 SGTC_2958 9077254 16.72 µM -0.282263197522173 0.385159718278948 no 2075 0.388870851396789 673 16457351 SGTC_2589 lobaric acid 100 µM -0.283494257117503 0.384709463864912 no 2076 0.388398991667052 673 73157 A novel microtubule depolymerizer. SGTC_2981 9013952 38.96 µM -0.284360997611437 0.384392550711198 no 2077 0.388066872578104 657 2996344 SGTC_2756 carbadox 75.1 µM -0.286748320143682 0.383520055213005 no 2078 0.387152518166984 658 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_602 3130-1533 38.1 µM -0.28678474807493 0.383506746447248 no 2079 0.387138570953102 683 720941 SGTC_1656 st012921 11 µM -0.287180117084066 0.383362309166083 no 2080 0.386987204834044 676 6732821 SGTC_140 0062-0056 502.533 µM -0.287832256863247 0.383124103117069 no 2081 0.386737572175625 674 3758964 SGTC_45 0kpi-0036 14.9 µM -0.288170990567955 0.38300039183178 no 2082 0.386607926745753 681 2795021 SGTC_641 4092-0595 30 µM -0.288654149170007 0.382823954780409 no 2083 0.386423026675002 664 786260 SGTC_424 splitomicin 100 mM -0.288848257833599 0.382753078150122 no 2084 0.386348750446549 707 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1204 4049-0315 18.3 µM -0.289256566288466 0.382604001655142 no 2085 0.386192523659051 670 588402 SGTC_836 0330-0104 1.35 µM -0.289496930503522 0.382516251000314 no 2086 0.386100564243071 660 46494820 SGTC_1565 sinapyl alcohol 95.1 µM -0.290809022619231 0.382037347112345 no 2087 0.385598692194749 687 5280507 A phenol propionate derived from cinnamic acid. SGTC_932 2857-0803 154 µM -0.291364360274153 0.381834707291355 no 2088 0.385386334511085 693 674898 SGTC_495 decylubiquinone 155 µM -0.291397039864075 0.38182278368708 no 2089 0.385373839107891 703 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2119 5528445 120.635 µM -0.292195067111788 0.381531647136034 no 2090 0.385068741510772 682 791935 SGTC_142 0335-0849 62.6745 µM -0.292361355403424 0.38147099022067 no 2091 0.385005175991851 652 3889043 YPR107C YTH1 SGTC_1788 fluconazole 20 µM -0.29322167021753 0.381157220041142 no 2092 0.384676360628113 709 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.293759680546629 0.38096103900043 no 2093 0.384470773314686 728 6728940 SGTC_422 cantharidin 155 µM -0.298763837137221 0.379137786427047 no 2094 0.382560122575267 657 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2473 5854593 8.94 µM -0.298870685954887 0.379098885453804 no 2095 0.382519357304803 670 2872951 SGTC_705 1124-0212 310 µM -0.301844950210175 0.378016523190514 no 2096 0.381385131371387 679 9554485 SGTC_1100 amiodarone 5.07 µM -0.302261606208872 0.377864974431661 no 2097 0.38122632204032 658 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_988 1497-1057 103 µM -0.304841759154467 0.376926924265773 no 2098 0.380243337532089 706 3533044 SGTC_133 0724-0033 378.92 µM -0.304911449585978 0.376901597393865 no 2099 0.380216797622509 669 280309 SGTC_1183 1254-0324 198 µM -0.304985649174203 0.376874632388029 no 2100 0.380188541129892 678 5799357 SGTC_2965 9082772 38.63 µM -0.305288092450466 0.376764727147279 no 2101 0.380073372091086 662 16459634 SGTC_507 nimesulide 162 µM -0.305618344113744 0.376644727988201 no 2102 0.379947625888776 688 4495 A COX2 inhibitor. SGTC_1191 1487-1166 10.6 µM -0.307155447649938 0.376086368096844 no 2103 0.379362527501542 713 3955771 SGTC_3149 9097855 49.47 µM -0.307313509961422 0.376028965921859 no 2104 0.379302376729047 663 25236625 YMR079W SEC14 SGTC_1200 1643-0193 18.4 µM -0.307773295202234 0.375862005137691 no 2105 0.37912742160636 701 5403974 SGTC_1982 st072467 71.9 µM -0.308288268047298 0.375675031792112 no 2106 0.378931496172605 706 3163533 SGTC_2837 9008476 45.46 µM -0.308292866251552 0.375673362434281 no 2107 0.378929746889976 729 2992805 SGTC_1217 1183-1422 255 µM -0.308904859535339 0.375451201743912 no 2108 0.378696950052315 672 2849664 SGTC_2089 5281248 129.67 µM -0.310176119338268 0.374989851690652 no 2109 0.378213514792352 671 2737878 SGTC_969 1313-0238 134 µM -0.311788164554264 0.374405085165426 no 2110 0.377600759662036 680 5212874 SGTC_3322 9139058 2.11 µM -0.312154347464889 0.374272293169803 no 2111 0.377461612597255 668 4908926 YPR165W RHO1 SGTC_676 falcarinol 140 µM -0.313095258259435 0.373931151188823 no 2112 0.377104145745185 717 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2307 7538926 6.34 µM -0.313525549965633 0.373775175055742 no 2113 0.376940706207742 675 96582 SGTC_166 k072-0058 166.424 µM -0.314117839997084 0.373560510077155 no 2114 0.37671577022099 698 5846229 SGTC_848 0368-0089 85.6 µM -0.314269274770847 0.373505631533049 no 2115 0.376658266039529 707 762535 SGTC_1494 4358-1428 177 µM -0.314296669822854 0.37349570409667 no 2116 0.376647863634972 710 1564571 SGTC_128 0906-2981 13.371 µM -0.314530694939201 0.373410901348594 no 2117 0.376559003650095 711 6740226 SGTC_222 nsc-310342 10.666 µM -0.31645116541965 0.372715220037105 no 2118 0.375830043153682 705 432556 SGTC_473 2-arachidonoylglycerol 10 µM -0.316641701234938 0.372646221934307 no 2119 0.375757744838418 658 5282280 An endocannabinoid. SGTC_2571 chrysanthemic acid 100 µM -0.31776064166311 0.372241106279244 no 2120 0.37533325392569 739 2743 An insecticide. SGTC_1966 st070145 16.1 µM -0.31955297736002 0.371592480606328 no 2121 0.374653612616669 676 3748532 SGTC_1627 st003713 25.6 µM -0.320024671175588 0.37142184053427 no 2122 0.374474814184929 675 16195070 YER133W GLC7 SGTC_653 0203-0016 55.2 µM -0.320697565153099 0.371178457981308 no 2123 0.374219796318546 708 295302 SGTC_2399 5884133 200 µM -0.322356030938274 0.370578818905813 no 2124 0.373591495004209 711 722445 SGTC_1967 st070177 51.4 µM -0.322566297167397 0.370502816935613 no 2125 0.373511860668776 723 5729214 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.323992212414855 0.36998754493714 no 2126 0.372971965052279 673 2724278 An inhibitor of dopamine biosynthesis. SGTC_3257 9139206 32.98 µM -0.324805793832675 0.369693651760703 no 2127 0.372664029630783 707 4910041 SGTC_898 1000-0849 28.3 µM -0.328895414647922 0.368217498084553 no 2128 0.371117370135064 700 6751807 SGTC_2662 daunorubicin 22.37 µM -0.329337686067836 0.368057975736527 no 2129 0.370950231039471 669 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_938 3126-1755 342 µM -0.330779484704768 0.367538093211668 no 2130 0.370405529112913 706 1777771 SGTC_2871 9038510 12.99 µM -0.333924017528705 0.36640508312367 no 2131 0.369218447830414 754 4945164 SGTC_1229 0139-0193 12.2 µM -0.334658710317442 0.366140532462105 no 2132 0.368941275754458 688 3090752 SGTC_1475 4092-1048 11.7 µM -0.334804541021676 0.36608802881248 no 2133 0.368886267391676 708 2881759 SGTC_523 1934-0222 13.7 µM -0.334951073049497 0.366035275189654 no 2134 0.368830997189839 718 1361595 SGTC_3238 9133470 49.47 µM -0.335230701105235 0.365934612123873 no 2135 0.368725532219789 693 3534688 SGTC_1162 k048-0130 20.1 µM -0.336107501666608 0.365619033299739 no 2136 0.368394900832253 715 6797406 SGTC_563 tetrahydrosecaminediol 614 µM -0.336724901637452 0.365396872707296 no 2137 0.368162144857245 703 334274 A psychoactive constituent of the cannabis plant. SGTC_826 1683-5028 118 µM -0.337644501425213 0.365066054525465 no 2138 0.367815551144891 714 722377 SGTC_1406 3909-7906 11.9 µM -0.338823986192771 0.364641891938411 no 2139 0.367371165303118 691 X1406 SGTC_570 0987-0065 62.6 µM -0.340367668687467 0.36408700804513 no 2140 0.366789831695723 667 3104428 SGTC_1098 clofazimine 15.1 µM -0.341886903467091 0.363541190052824 no 2141 0.366218002966688 682 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_551 k048-0028 34.9 µM -0.342612775621758 0.363280502440331 no 2142 0.365944894815509 730 6836383 SGTC_1374 2889-5571 141 µM -0.343411639899177 0.362993673834692 no 2143 0.365644402007049 686 2853281 SGTC_1980 st071811 45.7 µM -0.346846863029478 0.361761149891203 no 2144 0.364353184192933 729 4974850 SGTC_3151 9099821 49.47 µM -0.347242894710273 0.361619149520505 no 2145 0.364204423995368 737 17174189 SGTC_2241 6772625 37.8075 µM -0.347291658541373 0.36160166617065 no 2146 0.364186108397156 667 2285411 SGTC_3282 9108498 15.4605 µM -0.347561951497085 0.361504762980967 no 2147 0.364084592524852 712 16459645 SGTC_654 1124-0271 80.9 µM -0.34790690461523 0.361381106151573 no 2148 0.363955049849717 706 5403748 SGTC_3303 9125618 40.5795 µM -0.349061988956359 0.360967143580636 no 2149 0.363521386146633 711 22695467 SGTC_42 0133-0086 60.653 µM -0.351095293035788 0.36023883778102 no 2150 0.362758429536339 730 162923 Model of phenazepam hydroxylation. SGTC_535 2293-4129 48.2 µM -0.351984363335588 0.359920542295378 no 2151 0.362424994643539 740 396118 YIL048W NEO1 SGTC_1155 4088-0394 48.2 µM -0.352061014959754 0.359893104840856 no 2152 0.36239625227545 694 2326248 SGTC_3352 9151559 45.5865 µM -0.354908117549017 0.358874496765578 no 2153 0.361329213466409 677 17159339 SGTC_2596 sinensetin 100 µM -0.355066488229595 0.358817865851862 no 2154 0.361269890777913 683 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_115 0527-0192 112.043 µM -0.355783718787544 0.358561434130304 no 2155 0.361001271435333 725 4233931 SGTC_2022 5136654 200 µM -0.358010406648355 0.357765732221514 no 2156 0.360167762830412 733 1713771 SGTC_1808 st050063 61.5 µM -0.358035781906179 0.3577566679834 no 2157 0.360158268016015 737 4011993 SGTC_732 3970-1727 52.7 µM -0.359977861339989 0.357063180547114 no 2158 0.359431844694762 724 1275699 SGTC_314 1671-0008 2.74 µM -0.3601546252598 0.357000084202955 no 2159 0.359365752366879 732 3913060 SGTC_262 fenpropimorph 62.5 µM -0.361111661111323 0.35665853570086 no 2160 0.359007988150922 717 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_286 k060-0067 22.9 µM -0.362279783117197 0.356241810158871 no 2161 0.358571482144895 693 5985051 SGTC_106 0092-0003 11.579 µM -0.36292638381963 0.356011210218942 no 2162 0.358329938566602 709 1072148 SGTC_1368 1852-0141 284 µM -0.363195764413225 0.355915155415211 no 2163 0.358229325713078 726 2838987 SGTC_1767 st044992 70.3 µM -0.363620150753213 0.355763847752254 no 2164 0.358070838643817 718 9600693 SGTC_1247 0448-0043 5.84 µM -0.365807222146268 0.354984445724818 no 2165 0.357254465183769 732 3089013 YGL099W LSG1 SGTC_1167 k781-0610 148 µM -0.365885497387004 0.354956562163766 no 2166 0.357225259275412 706 4525169 SGTC_51 1013-0126 23.419 µM -0.366368049369749 0.3547846824707 no 2167 0.357045228879549 741 1627850 SGTC_2679 rapamycin 1 nM -0.36718893228275 0.354492360952088 no 2168 0.356739047185847 720 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_3047 9092122 49.47 µM -0.367548380315557 0.354364386233342 no 2169 0.356605005450409 738 17173831 SGTC_1531 st059297 52.4 µM -0.37262121781331 0.352560057216257 no 2170 0.354715189417088 694 7566702 SGTC_673 1082-0474 110 µM -0.372646289992122 0.35255114762738 no 2171 0.35470585794925 730 3098046 SGTC_1348 1493-0373 93.8 µM -0.372797076143724 0.352497566331189 no 2172 0.354649739570943 729 3010129 SGTC_2699 st077704 54.6 µM -0.372876453125114 0.352469361192917 no 2173 0.354620198951121 706 645852 SGTC_3323 9138564 53.9225 µM -0.373066082910997 0.352401983049262 no 2174 0.354549630628329 688 43912313 YNL103W MET4 SGTC_3181 9108277 49.47 µM -0.373723971902708 0.352168261709561 no 2175 0.354304844290511 733 17097298 SGTC_2690 usnic acid 100 µM -0.3747976805365 0.351786936414866 no 2176 0.353905469703903 748 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3129 9127257 49.47 µM -0.374931809538728 0.351739311255414 no 2177 0.353855590621844 744 837894 SGTC_70 0141-0289 43.283 µM -0.375449202872059 0.351555622304456 no 2178 0.353663209024844 678 352408 SGTC_1134 3477-0009 42.5 µM -0.376201319465063 0.351288661917448 no 2179 0.35338361727892 729 3973534 SGTC_1571 st070080 73.4 µM -0.376372261802192 0.351227996933203 no 2180 0.353320082218813 709 4315245 SGTC_2659 sanguinarine 24.21 µM -0.376973910935101 0.351014510440738 no 2181 0.35309649656335 733 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_3061 glucosamine 200 µM -0.377206278724618 0.350932070674063 no 2182 0.35301015730406 706 91431 and experimental redox chemotherapeutic SGTC_919 tnp00227 403.569 nM -0.377337504200679 0.350885517417535 no 2183 0.352961402123432 725 1269246 A methoxyflavone. YNL221C POP1 SGTC_1501 4491-0275 38.4 µM -0.378128499687744 0.350604953059499 no 2184 0.352667568824391 721 5104718 SGTC_245 methotrexate 289.6 µM -0.378419462400964 0.350501769713177 no 2185 0.352559506192159 707 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1932 st074806 40.9 µM -0.379352198547557 0.350171070318738 no 2186 0.352213171176742 711 17251235 SGTC_2619 obliquin 87.91 µM -0.380112790182418 0.349901488408832 no 2187 0.351930845959274 706 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2490 carminic acid 95.39 µM -0.381136140797829 0.349538894335824 no 2188 0.351551115616169 719 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1682 st012968 530 nM -0.386171159598789 0.347756888275843 no 2189 0.349684955763841 696 24207270 SGTC_2475 5812728 15.03 µM -0.387124075825156 0.347420006585086 no 2190 0.349332177313986 714 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1907 st060210 83.7 µM -0.387491191794228 0.347290253284765 no 2191 0.349196302272525 718 688793 SGTC_216 k038-0035 28.382 µM -0.388324457913771 0.346995810516486 no 2192 0.348887969921087 700 4444231 YPR107C YTH1 SGTC_3254 9136651 49.47 µM -0.388782829767279 0.346833879683852 no 2193 0.348718401712875 741 16454030 SGTC_2627 acetyl isogambogic acid 100 µM -0.389111178980277 0.346717899656476 no 2194 0.348596952121283 728 6857789 A caspase activator and apoptosis inducer. SGTC_2346 9031566 143.75 µM -0.391402817551265 0.345908843945239 no 2195 0.347749755003005 720 4771086 SGTC_2041 5107442 45.335 µM -0.392627677951701 0.345476698927685 no 2196 0.347297246934327 718 793005 SGTC_66 0109-0187 42.4 µM -0.394931811164481 0.344664319828211 no 2197 0.346446606196717 694 759417 SGTC_630 4356-0227 183 µM -0.394939046960627 0.34466176979506 no 2198 0.346443936099547 738 779312 SGTC_466 geldanamycin 89.2 µM -0.394985477894345 0.344645406812677 no 2199 0.346426802699383 709 5288382 HSP90 inhibitor. SGTC_147 4466-0538 29.23 µM -0.396119978295868 0.344245681627836 no 2200 0.346008260341099 738 6742687 YHR072W ERG7 SGTC_3199 9111318 49.47 µM -0.399288587370103 0.343130189492873 no 2201 0.344840287677021 714 8548020 SGTC_1116 jasmonic acid  1.58368 µM -0.40305171267893 0.341807175349838 no 2202 0.343455091133324 739 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_3340 9146634 11.102 µM -0.403313909202744 0.341715066200099 no 2203 0.343358655324994 733 4907387 SGTC_1878 temozolomide 1 mM -0.404841767463438 0.341178520036379 no 2204 0.34279691249921 731 5394 DNA alkylating agent. SGTC_356 1634-0012 32.5 µM -0.407458523188218 0.340260325954945 no 2205 0.341835625688462 760 735457 SGTC_2546 rhodinyl acetate 100 µM -0.416141761743861 0.337220267566046 no 2206 0.338653136214888 720 6708682 SGTC_1540 guanosine 70.6 µM -0.416162386890137 0.337213059108788 no 2207 0.338645590489594 728 6802 Guanosine is a purine nucleoside SGTC_2050 5263056 171 µM -0.4165343401611 0.337083072265345 no 2208 0.338509522223984 725 763468 YGL055W OLE1 SGTC_758 0868-0029 16 µM -0.417338595961085 0.336802074780856 no 2209 0.33821538076251 694 762687 SGTC_1880 MG-132 525 µM -0.417475564580263 0.336754228633577 no 2210 0.338165296893855 730 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2141 5621638 7.665 µM -0.418059322353012 0.336550338855017 no 2211 0.337951872474826 744 2856238 SGTC_143 4032-1194 15.74 µM -0.41897523696349 0.33623053310465 no 2212 0.337617115030896 724 1806963 SGTC_918 glabranin 770.725 nM -0.419751819645472 0.335959470054167 no 2213 0.337333382591609 728 124049 Also referred to as licorice root. SGTC_2597 laccaic acid a 100 µM -0.420226756096824 0.33579373742705 no 2214 0.337159905254926 738 5491415 A textile dye. SGTC_342 k048-0088 23.3 µM -0.420273778120284 0.335777330476898 no 2215 0.337142731670752 689 6820570 SGTC_99 0109-0120 622.8 µM -0.420453903927181 0.335714483778127 no 2216 0.337076948494852 751 759414 SGTC_324 1315-0088 19.6 µM -0.42083524450493 0.335581447509046 no 2217 0.336937696749373 745 6787421 SGTC_3347 9188721 44.724 µM -0.422343095704369 0.335055613423887 no 2218 0.336387303212302 749 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2375 9072683 200 µM -0.422469891718989 0.335011410468684 no 2219 0.336341036282148 757 16798029 SGTC_2061 5245884 80.95 µM -0.423375161855876 0.334695886419396 no 2220 0.336010781937192 739 573863 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.423648095229615 0.334600780743988 no 2221 0.335911237103988 732 616764 SGTC_2361 9034121 116 µM -0.424541802735441 0.33428943596786 no 2222 0.335585362804188 747 6496917 SGTC_2581 avocatin a 64 µM -0.424758860318522 0.334213835865334 no 2223 0.335506235326678 768 6710728 A skin care supplement. SGTC_587 k089-0003 57 µM -0.424760854882339 0.334213141199616 no 2224 0.335505508250203 714 9659696 SGTC_1831 st055328 12 µM -0.428117862286746 0.333044770698409 no 2225 0.334282656363288 742 1103068 SGTC_731 3966-0296 387 µM -0.431069025249706 0.332018986430827 no 2226 0.333209090999668 717 660956 SGTC_1380 2291-0730 164 µM -0.434511738261873 0.33082393547207 no 2227 0.331958436348618 733 2999191 SGTC_218 alverine citrate 93.75 µM -0.434939975147612 0.330675404024522 no 2228 0.331802998698214 740 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_517 1365-0151 113 µM -0.435074923024079 0.330628603669609 no 2229 0.331754022504894 740 768657 SGTC_928 2764-0428 58.7 µM -0.43590834150412 0.33033963017506 no 2230 0.331451616392975 749 662578 SGTC_2030 5175110 200 µM -0.436171362497637 0.330248453168523 no 2231 0.331356201951948 773 2831986 SGTC_2019 4016004 108 µM -0.438435908123244 0.329463859141502 no 2232 0.33053516060469 732 45595336 SGTC_224 benfluorex 43.875 µM -0.438989423515241 0.329272197380561 no 2233 0.330334599970657 744 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_712 r015-0009 80.6 µM -0.439182075350278 0.329205499747342 no 2234 0.330264805979873 714 6813872 YLR060W FRS1 SGTC_991 3996-0057 64.7 µM -0.439232673725352 0.329187983079296 no 2235 0.330246476157517 717 715343 SGTC_3195 9113082 49.47 µM -0.439467894268982 0.32910655692627 no 2236 0.330161270256986 734 17018038 SGTC_889 0919-1524 82.7 µM -0.439767427100372 0.329002879563058 no 2237 0.330052780728985 736 3905452 SGTC_3117 9124945 49.47 µM -0.439803228715243 0.328990488422308 no 2238 0.330039814491016 724 17592065 SGTC_2671 danthron 100 µM -0.440816279520448 0.32863994376206 no 2239 0.329673003483784 733 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2888 9058547 12.99 µM -0.442098606980609 0.328196437833419 no 2240 0.329208926195219 718 16476514 SGTC_155 k072-0202 43.6 µM -0.442602884334903 0.328022094685456 no 2241 0.329026499068062 761 5857737 SGTC_232 clozapine 119 µM -0.4458160503682 0.32691209225161 no 2242 0.32786506343998 731 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1277 0873-0036 22 µM -0.445839057347078 0.326904149893629 no 2243 0.327856753287462 745 5965735 SGTC_958 1222-0007 33 µM -0.447043949102079 0.326488312650517 no 2244 0.327421663933032 756 7312461 SGTC_1382 3002-2117 298 µM -0.447281960824339 0.326406194533621 no 2245 0.327335745015132 762 1497314 SGTC_828 2074-0507 139 µM -0.448096779344341 0.326125131921895 no 2246 0.327041676150829 733 X828 SGTC_2496 diffractaic acid 79.83 µM -0.448196142112217 0.326090864588559 no 2247 0.327005823363414 724 94870 An apoptosis inducer which activates caspases. SGTC_1260 0700-1617 7.75 µM -0.448987624820976 0.325817957642431 no 2248 0.326720291925047 711 2853078 SGTC_1300 1094-0077 113 µM -0.452024076330728 0.324771841596279 no 2249 0.325625818927105 723 5532636 SGTC_2641 levomentholum 100 µM -0.452524969072961 0.324599406828168 no 2250 0.325445418797269 745 16666 SGTC_1453 4237-0541 195 µM -0.453026762412564 0.324426699716087 no 2251 0.325264735307184 752 739892 SGTC_337 1315-0038 354 µM -0.454243911786688 0.324007938458423 no 2252 0.324826640328438 751 1626437 SGTC_37 0566-0070 1.56 µM -0.454423294991485 0.323946240326498 no 2253 0.324762094448963 743 1626686 SGTC_403 arphamenine a 50 µM -0.455816225333385 0.323467312231418 no 2254 0.324261067759841 762 5487158 An arginine aminopeptidase inhibitor. SGTC_722 3534-0461 190 µM -0.457270610668172 0.322967566129795 no 2255 0.323738275544771 722 658262 SGTC_3188 9110789 49.47 µM -0.458273039994101 0.322623304010502 no 2256 0.323378145367169 745 849217 SGTC_1710 st031758 61.5 µM -0.459632166712395 0.322156784865581 no 2257 0.322890133212057 751 5394341 SGTC_384 k007-0144 5.16 µM -0.461297814292517 0.321585434616857 no 2258 0.322292476436191 727 6824886 SGTC_2312 7706453 155.7 µM -0.462520392235898 0.321166334365327 no 2259 0.321854091057019 740 976098 SGTC_2328 6201408 200 µM -0.465184754655071 0.320253779015957 no 2260 0.320899577644119 779 2890418 SGTC_1706 st031321 9.9705 µM -0.466407577560477 0.31983532026764 no 2261 0.320461894293296 736 6103185 SGTC_487 nimodipine 119 µM -0.466457308661109 0.319818306775553 no 2262 0.32044409938511 737 4497 L-type voltage-gated calcium channels inhibitor SGTC_1689 st020265 53.493 µM -0.467076383393733 0.319606547041606 no 2263 0.320222615062954 760 5758320 YPR016C TIF6 SGTC_1360 1598-0022 39.8 µM -0.467197795815072 0.319565023793529 no 2264 0.320179185250555 776 761525 SGTC_468 gf-109203x 121 µM -0.468940820739565 0.318969155949013 no 2265 0.319555968561103 735 2396 A protein kinase C inhibitor. SGTC_1414 3917-0015 5.4 µM -0.470908835567087 0.318296935366197 no 2266 0.318852919075838 755 6618702 SGTC_1678 st019265 80.2 µM -0.471560126998576 0.318074603413012 no 2267 0.318620396413122 766 5367020 SGTC_1557 sumaresinolic acid 42.3 µM -0.473382742437668 0.317452764065859 no 2268 0.317970069919989 745 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_686 1319-0111 510 µM -0.473752388272168 0.317326711155469 no 2269 0.317838245130822 800 4562600 SGTC_1660 st012960 28.1 µM -0.473910190849378 0.317272905356849 no 2270 0.317781975883289 772 24207266 SGTC_1327 1436-0082 2.18 µM -0.474643527226905 0.317022911019132 no 2271 0.317520538008764 748 15992205 SGTC_1295 1013-0063 9.78 µM -0.475014839254141 0.316896362600781 no 2272 0.317388198211241 750 6826038 SGTC_3114 9122766 49.47 µM -0.477141867016929 0.316171854429645 no 2273 0.316630551732837 726 17176985 SGTC_3264 9137442 49.47 µM -0.47841042458058 0.315740093899369 no 2274 0.316179057703089 755 17015726 SGTC_1493 4348-0038 111 µM -0.478569812073221 0.315685863252341 no 2275 0.316122349245278 767 800424 SGTC_2809 7964133 12.99 µM -0.482561585232432 0.314328982862423 no 2276 0.3147035303043 775 1253665 SGTC_1333 1482-0047 286 µM -0.482837377648478 0.314235328030628 no 2277 0.314605604456552 769 3811116 SGTC_130 0136-0219 337.655 µM -0.48305251644123 0.314162278532103 no 2278 0.314529223995206 796 234244 SGTC_2785 7756463 72.73 µM -0.483194758747152 0.314113984735301 no 2279 0.314478728242664 761 2201551 SGTC_503 tyrphostin 8 294 µM -0.483991909082935 0.313843396913518 no 2280 0.314195805609764 783 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.485270988879088 0.313409430253168 no 2281 0.313742065865529 768 7104 SGTC_737 1950-0117 57.9 µM -0.485643633190242 0.313283047896383 no 2282 0.313609927256871 753 5393513 SGTC_2021 4019055 173 µM -0.486164891153714 0.313106299990956 no 2283 0.3134251307914 770 44827708 YER133W GLC7 SGTC_600 1495-0418 41.6 µM -0.487220457317862 0.312748510647274 no 2284 0.313051054747667 753 5377768 SGTC_3248 9135562 49.47 µM -0.488876313343855 0.312187605482472 no 2285 0.31246463304676 746 17650701 SGTC_2213 7173844 200 µM -0.489423726028792 0.312002270368342 no 2286 0.312270871055668 754 892728 SGTC_2639 lactacystin 53 µM -0.489603868941273 0.311941290575137 no 2287 0.312207119085963 742 3870 A proteasome inhibitor. SGTC_1650 st011916 45.8 µM -0.490007540239166 0.311804663381724 no 2288 0.312064281592425 777 242528 SGTC_544 k015-0020 52.4 µM -0.49074970884426 0.311553535465463 no 2289 0.311801741894813 762 3008304 SGTC_1556 plumbagin 1.48 µM -0.491671196499873 0.311241853241898 no 2290 0.311475901730833 762 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1359 1582-0056 520 nM -0.492265062239754 0.311041056899889 no 2291 0.311265987630253 780 3661189 SGTC_1700 st030840 7.9285 µM -0.492408537502226 0.310992553848846 no 2292 0.311215282538365 752 5499307 SGTC_351 caspofungin 25 nM -0.492989384987831 0.310796226898002 no 2293 0.311010043869136 750 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2362 9071156 126 µM -0.493028425010445 0.310783033267604 no 2294 0.310996251438772 768 653133 SGTC_2477 5967686 25.23 µM -0.494781126488831 0.310190956199985 no 2295 0.310377314132775 750 776118 SGTC_1487 3970-0795 2.82 µM -0.494985209565781 0.310122047178248 no 2296 0.310305280441684 749 3765103 SGTC_618 k072-0232 33.2 µM -0.497119600577045 0.30940176605715 no 2297 0.309552356682127 773 5872756 YGL099W LSG1 SGTC_1759 st043059 70 µM -0.498094181450276 0.309073122783726 no 2298 0.309208830739571 778 669426 SGTC_271 rotenone 740 µM -0.498641205427227 0.30888872501279 no 2299 0.309016085577331 790 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1668 st014914 51.6 µM -0.499776533111447 0.308506168113809 no 2300 0.308616218063946 762 2839556 SGTC_1094 duloxetine 25.4 µM -0.499833724284953 0.308486902627137 no 2301 0.308596081073177 744 60834 A selective serotonin reuptake inhibitor. SGTC_61 0978-8327 98.565 µM -0.499939570799818 0.308451248435388 no 2302 0.308558814073494 780 6150059 YHR072W ERG7 SGTC_2506 ethyl hematommate 54.16 µM -0.500653126456455 0.308210935756274 no 2303 0.308307633104428 756 3940691 An allergen. SGTC_3312 9133330 71.43 µM -0.502449605078108 0.307606278230069 no 2304 0.307675646507592 780 17617324 SGTC_2139 5578692 56.4705 µM -0.502752040718931 0.307504535974466 no 2305 0.307569308138888 768 650991 YMR113W FOL3 SGTC_2519 cryptotanshinone 88.04 µM -0.502837188834843 0.307475894001073 no 2306 0.307539372415349 771 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_846 0335-0850 148 µM -0.503504020629675 0.307251626899249 no 2307 0.307304977126982 769 6819598 SGTC_3089 9117425 49.47 µM -0.504980696996386 0.306755251591633 no 2308 0.30678619688686 790 9401657 SGTC_2557 derrustone 83.84 µM -0.505936487371288 0.306434157508118 no 2309 0.30645061840298 800 629853 An antioxidant. SGTC_1048 3161-0300 24.5 µM -0.507047357675144 0.306061151599393 no 2310 0.30606079514981 736 2165101 SGTC_2917 7979103 53.79 µM -0.507790486238882 0.305811737486973 no 2311 0.305800141234724 776 2980565 SGTC_1318 1280-3875 124 µM -0.509409435202138 0.305268686143131 no 2312 0.305232632094485 776 373245 SGTC_2709 st078560 56 µM -0.509868534670129 0.30511476624579 no 2313 0.305071783678597 788 17250903 SGTC_2610 ononetin 44.17 µM -0.513424590939152 0.303923714689215 no 2314 0.303827173817252 763 259632 SGTC_1281 0884-0031 11.8 µM -0.513866164631169 0.303775960548623 no 2315 0.303672782470339 757 1548255 SGTC_1087 pterostilbene 9.05 µM -0.51534003888344 0.303283022456412 no 2316 0.303157712383344 775 5281727 Similar to reservatol, lowers cholesterol. SGTC_417 st075190 100 µM -0.518089388817177 0.302364457794005 no 2317 0.302197951701958 772 222757 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.521798111031107 0.301127345652368 no 2318 0.300905452515919 778 688788 SGTC_1462 k081-0014 26.5 µM -0.523858555015174 0.300441033902806 no 2319 0.300188461457171 765 3270634 SGTC_2327 6189656 200 µM -0.523994656016315 0.30039572501058 no 2320 0.30014112838801 787 5349088 SGTC_850 0388-0143 75.9 µM -0.524017407147471 0.30038815131494 no 2321 0.300133216351795 773 67273 SGTC_1746 st038117 42 µM -0.527610478190733 0.299193127067353 no 2322 0.298884859451247 762 2898218 SGTC_1232 0279-0259 161 µM -0.527723894551509 0.299155440917862 no 2323 0.298845493124789 768 1560000 SGTC_536 3852-0578 10.6 µM -0.529236000754073 0.29865320210238 no 2324 0.298320872876292 758 2869208 SGTC_107 0358-0022 2.6945 µM -0.530030903782077 0.298389332720174 no 2325 0.298045252138901 799 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2584 androsterone 48.74 µM -0.532018006248908 0.297730175374311 no 2326 0.297356762222311 761 2754130 A steroid. SGTC_365 0121-0052 13.6 µM -0.532032421498478 0.297725396006699 no 2327 0.29735177029187 744 3101739 SGTC_3283 9109332 35.8195 µM -0.534404940067786 0.296939266293343 no 2328 0.296530700942296 759 17027281 SGTC_1304 1165-0502 251 µM -0.53446098869199 0.296920706171484 no 2329 0.296511316481149 753 767425 SGTC_2248 tofa 1.1 µM -0.535434991565271 0.29659825652044 no 2330 0.296174549575593 783 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_558 k064-0027 21.3 µM -0.535641853887824 0.296529794131317 no 2331 0.296103048375938 752 5088526 SGTC_913 3487-1245 167 µM -0.536469701743056 0.296255885165461 no 2332 0.295816985127212 738 4016153 SGTC_1209 2323-2347 50.3 µM -0.539772309982209 0.295164312063395 no 2333 0.294677032658704 766 5412760 SGTC_3010 9080089 71.4286 µM -0.541218061347921 0.294687047970673 no 2334 0.29417864494088 771 17027233 SGTC_881 0833-0569 170 µM -0.541604009075457 0.294559701083239 no 2335 0.294045664713974 740 5418700 SGTC_2567 aureobasidin a 60 nM -0.542345405808161 0.294315141901418 no 2336 0.293790290738151 771 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1042 0350-0096 82 µM -0.542977645853387 0.294106663554556 no 2337 0.293572596863833 759 3122515 SGTC_1987 st072290 61.9 µM -0.543410711958817 0.29396390132674 no 2338 0.293423525985244 778 54697379 SGTC_3071 9117417 49.47 µM -0.544778010852426 0.293513375401029 no 2339 0.292953101928159 768 45595590 YGL055W OLE1 SGTC_2761 levamisole 97.89 µM -0.545507468805275 0.293273149385407 no 2340 0.292702272566025 794 26879 An alkaline phosphatase inhibitor. SGTC_2543 pimpinellin 60.67 µM -0.546397691089711 0.292980103792966 no 2341 0.292396298446036 765 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1215 3852-0577 11.2 µM -0.547825632611504 0.292510334406676 no 2342 0.291905818196145 755 2884876 SGTC_799 1310-0557 151 µM -0.551791196288018 0.291207568400737 no 2343 0.290545709838427 799 5354492 SGTC_801 0866-0028 10.1 µM -0.55298676213349 0.290815333529034 no 2344 0.290136237440626 780 6849771 SGTC_971 1315-0384 26.7 µM -0.553008519848664 0.290808197662686 no 2345 0.290128788091324 796 6769120 SGTC_2479 5617353 43.85 µM -0.55550947211678 0.289988507717561 no 2346 0.28927311652826 801 2731746 SGTC_2116 5511452 16.8835 µM -0.555960677237633 0.289840740149474 no 2347 0.289118868362119 797 870744 SGTC_2810 7959871 45.46 µM -0.558856152307264 0.288893327236111 no 2348 0.288129948170659 775 2974535 SGTC_940 3232-1287 54.8 µM -0.559337660339248 0.288735917011886 no 2349 0.28796564888174 797 1585493 YIL048W NEO1 SGTC_857 0438-0306 1.35 µM -0.560046272027407 0.28850433760427 no 2350 0.287723938173412 766 4686136 SGTC_3108 9121785 49.47 µM -0.561707697583722 0.287961715218027 no 2351 0.28715759445309 770 17140271 SGTC_176 1486-1328 72.834 µM -0.562385502842939 0.287740482159283 no 2352 0.286926697093342 763 22310231 SGTC_506 n9-isopropylolomoucine 153 µM -0.563398531428118 0.287409983262301 no 2353 0.286581768490166 791 6610355 SGTC_1694 st024011 44.9 µM -0.564065600217162 0.287192451268242 no 2354 0.286354744043618 796 2787533 SGTC_1973 st070275 50.2 µM -0.564094216436109 0.287183121225863 no 2355 0.286345006956117 776 17118334 SGTC_175 3793-3120 23.7 µM -0.564924395617011 0.286912511785273 no 2356 0.286062594778368 821 5322297 SGTC_1305 1181-0477 144 µM -0.565564251928249 0.286704023436787 no 2357 0.285845017406529 779 6252086 SGTC_1488 4013-0813 75.9 µM -0.565615719472479 0.286687256569574 no 2358 0.285827519751902 772 2910057 SGTC_1216 1165-0504 9.65 µM -0.565926867106894 0.286585902182785 no 2359 0.285721748327294 790 6304004 SGTC_1208 2323-2347 50.3 µM -0.566679208639024 0.286340901913335 no 2360 0.285466074563571 780 5412760 SGTC_858 0438-0351 2.77 µM -0.567153849381897 0.286186386166673 no 2361 0.285304829962712 784 2799119 SGTC_2290 7904846 200 µM -0.568628871645685 0.285706456628158 no 2362 0.284804013611489 767 2962154 SGTC_2611 pyromycin 23.93 µM -0.568827334711947 0.285641911728101 no 2363 0.284736661203427 780 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2285 7945142 200 µM -0.569925656594314 0.285284836888593 no 2364 0.284364061236884 808 2970608 SGTC_603 3794-0023 45.9 µM -0.571515984389836 0.284768183469663 no 2365 0.283824964136975 802 3802260 SGTC_759 3486-0358 89.3 µM -0.571930477135623 0.284633599658973 no 2366 0.283684537778979 817 875103 SGTC_762 1165-0429 115 µM -0.572429943472768 0.284471465685968 no 2367 0.283515367366288 801 5967793 SGTC_2739 tacrine 100.86 µM -0.574742143335285 0.283721467712795 no 2368 0.282732850470291 782 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2002 4023503 131 µM -0.574855236298444 0.283684808556312 no 2369 0.282694603097877 822 4736863 YCR052W RSC6 SGTC_2093 5331342 194.4 µM -0.576619045059566 0.283113362622161 no 2370 0.282098415385467 787 33839 SGTC_1974 st069448 26.9 µM -0.577049135109611 0.282974104113369 no 2371 0.281953131845164 783 6323587 YNR016C ACC1 SGTC_2302 7771753 200 µM -0.577795652468668 0.282732467969703 no 2372 0.281701045413493 773 2203047 SGTC_1935 st074532 41.6 µM -0.57846004299222 0.282517498428665 no 2373 0.281476783266905 795 2829742 SGTC_1468 k284-1086 134 µM -0.579397171515068 0.282214415717813 no 2374 0.281160606099335 787 15996457 SGTC_2544 sphondin 68.51 µM -0.580683812567136 0.281798550028937 no 2375 0.280726786750425 779 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2752 diclazuril 33.15 µM -0.580918115312896 0.281722850939541 no 2376 0.280647821281881 787 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1725 st036284 20.55 µM -0.581002915578818 0.281695455883795 no 2377 0.280619244270835 757 707914 SGTC_3003 9075612 71.4286 µM -0.585411622520874 0.280272977940665 no 2378 0.279135487828141 810 6501993 SGTC_1920 st075728 45.7 µM -0.588571001272581 0.279255742861448 no 2379 0.27807454581535 796 3400306 SGTC_1634 st006576 41 µM -0.588743866287045 0.279200136783214 no 2380 0.278016553314556 797 3915356 SGTC_19 0279-0214 38.434 µM -0.589101247248022 0.279085193899367 no 2381 0.277896678389888 787 3566274 YBR002C RER2 SGTC_1837 st055472 66.5 µM -0.590432700227536 0.278657167128811 no 2382 0.277450296443453 776 676091 SGTC_1886 st057356 49.9 µM -0.591264098996356 0.278390056717094 no 2383 0.277171740175483 766 24207747 SGTC_2315 7733312 200 µM -0.592888818539003 0.277868429988812 no 2384 0.276627780771206 783 726316 SGTC_194 1486-1323 56.904 µM -0.593178111663474 0.277775600623336 no 2385 0.276530979747976 803 5178754 SGTC_2185 6113692 200 µM -0.593573177866468 0.277648854897195 no 2386 0.276398812587581 802 874150 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.593790319840177 0.277579203120006 no 2387 0.27632618216685 803 4213774 SGTC_3216 9129716 49.47 µM -0.594648600556666 0.277303979383718 no 2388 0.276039193052808 773 8056934 SGTC_1004 4084-0029 199 µM -0.595309918259244 0.277092006585081 no 2389 0.27581816366722 780 716894 YLR208W SEC13 SGTC_824 1304-0008 100 µM -0.59746681169997 0.276401207024232 no 2390 0.275097879331686 785 768245 SGTC_2700 st077718 96.8 µM -0.599980304492985 0.27559726469064 no 2391 0.274259680816356 788 904970 SGTC_1381 2324-0066 62.1 µM -0.600839927137775 0.275322577922886 no 2392 0.273973303908929 815 10885928 SGTC_976 1348-1067 47.6 µM -0.603887415317473 0.274349860011714 no 2393 0.27295924811454 798 5310671 YGL099W LSG1 SGTC_936 3005-4620 401 µM -0.604042439081 0.274300423859903 no 2394 0.27290771353304 807 777207 SGTC_367 0335-0881 7.1 µM -0.604585526195521 0.274127271326039 no 2395 0.272727213041108 816 23828853 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.604698615902297 0.274091221714339 no 2396 0.272689633987193 828 229346 A bile salt which induces apoptosis. SGTC_1961 st076550 68.7 µM -0.60574971149655 0.273756276013627 no 2397 0.27234048399193 802 1579337 SGTC_810 3825-7150 143 µM -0.606336983487842 0.273569222114775 no 2398 0.27214550237949 775 22330411 YGL099W LSG1 SGTC_617 3770-0098 35 µM -0.607227577012411 0.273285677040163 no 2399 0.271849946712905 803 5962639 SGTC_1604 st002052 72.4 µM -0.607557736731716 0.273180598561773 no 2400 0.27174041927642 770 6254834 YHR062C RPP1 SGTC_672 1441-0018 53.7 µM -0.607759467522494 0.27311640444656 no 2401 0.271673507761949 779 251141 SGTC_2933 9026794 32.47 µM -0.609116274151064 0.272684840190479 no 2402 0.271223685627603 792 17586027 SGTC_465 cgp-37157 41 µM -0.610886380129594 0.272122325575319 no 2403 0.270637401064711 767 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_3068 9116768 49.47 µM -0.6134633360664 0.271304438034091 no 2404 0.269785009182084 813 41904888 SGTC_2463 5473429 200 µM -0.616722345153805 0.270271834494132 no 2405 0.268708939974863 790 5399405 SGTC_2063 5246145 200 µM -0.617136839210027 0.270140644760995 no 2406 0.268572235833799 812 711240 SGTC_1426 4048-4480 71.7 µM -0.617834681034464 0.269919845822855 no 2407 0.268342159857344 798 14224343 SGTC_2486 5283202 22.39 µM -0.617938936424645 0.269886866908135 no 2408 0.268307795738057 791 1377751 SGTC_2316 5844804 197.44 µM -0.618684315585468 0.269651141275425 no 2409 0.268062172244701 795 776813 SGTC_234 nsc-17383 10.7 µM -0.619054297218259 0.269534173161183 no 2410 0.267940294893947 793 408974 SGTC_2497 7-hydroxyflavone 100 µM -0.619946871542784 0.269252094300238 no 2411 0.267646382792995 812 5281894 SGTC_2489 cantharidin 73.42 µM -0.622628948241616 0.268405373722532 no 2412 0.2667641917714 801 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_203 k066-0004 30.888 µM -0.623504974981685 0.268129106067861 no 2413 0.266476367005399 808 6795412 SGTC_942 3253-1115 227 µM -0.624879302015679 0.267695980811168 no 2414 0.266025138910032 839 46497897 SGTC_1338 1486-1223 76 µM -0.625315093793629 0.267558712768015 no 2415 0.265882137746856 795 3444526 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.629272231939203 0.266313898424112 no 2416 0.264585423613711 793 279621 SGTC_2504 purpurogallin 52.29 µM -0.629282407632492 0.26631070119372 no 2417 0.26458209329383 789 5281571 An antioxidant. SGTC_408 cantharidin 100 µM -0.630311861282466 0.265987344494596 no 2418 0.264245282029004 799 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3278 9139605 49.47 µM -0.631634962822057 0.265572043768816 no 2419 0.263812717458926 822 7958859 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.633052314204359 0.265127524666395 no 2420 0.263349740465259 819 688662 SGTC_632 0781-2353 4.65 µM -0.633105357555518 0.26511089619909 no 2421 0.263332421942887 819 6811515 YHR007C ERG11 SGTC_2396 5342950 42.78 µM -0.6331713645643 0.265090204517207 no 2422 0.263310871630667 816 1886677 SGTC_2515 chrysin 20.77 µM -0.633176948088973 0.265088454248038 no 2423 0.263309048733748 795 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_236 1509-0011 5.31 µM -0.633918691644001 0.264855991869975 no 2424 0.263066943228486 835 3107280 SGTC_3236 9132701 49.47 µM -0.634530210864501 0.26466441974847 no 2425 0.262867428608546 809 24282524 SGTC_589 1227-0070 34.1 µM -0.634598085537169 0.26464316082984 no 2426 0.262845288549521 799 2841384 SGTC_1256 0570-0116 285 µM -0.634752471213738 0.264594809171599 no 2427 0.262794932992714 812 410638 SGTC_887 0885-0007 9.62 µM -0.635163337518595 0.264466152894199 no 2428 0.26266094588802 806 5719458 SGTC_1433 4060-0023 7.6 µM -0.635772944086001 0.264275322927494 no 2429 0.262462212263816 808 3840627 SGTC_2118 5526350 200 µM -0.637064811681292 0.263871151256304 no 2430 0.26204131400876 814 743594 SGTC_635 k038-0028 24.7 µM -0.638318581704043 0.263479200278239 no 2431 0.261633159260536 825 4035102 SGTC_457 grayanotoxin iii 135 µM -0.638930332246936 0.263288064022179 no 2432 0.261434127293777 818 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_585 0kpi-0023 191 µM -0.640451206958069 0.262813186697857 no 2433 0.260939650517618 796 64601 SGTC_1122 capsaicin 818.572 nM -0.640996992165382 0.262642877804583 no 2434 0.260762318589101 813 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2235 salicylic acid 500 µM -0.641330828686743 0.262538734027387 no 2435 0.260653881812371 811 338 A COX inhibitor and kinase inhibitor. SGTC_797 k781-0471 270 µM -0.641397080269079 0.26251806867061 no 2436 0.260632364734174 803 23738129 SGTC_492 tmb-8 126 µM -0.641473397049574 0.262494264784453 no 2437 0.260607579830973 795 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2272 7805186 180 µM -0.644961031958908 0.261407620541346 no 2438 0.259476219425549 843 2956062 YPR165W RHO1 SGTC_607 4491-0986 66.8 µM -0.645061661991691 0.261376301513459 no 2439 0.259443613553465 805 698981 YDR232W HEM1 SGTC_1968 st069590 43.6 µM -0.645319536645764 0.261296052129584 no 2440 0.259360067364482 822 6384066 SGTC_2128 5255449 168.493 µM -0.645612084459815 0.261205027947956 no 2441 0.259265304602256 796 736008 SGTC_2978 9011784 42.97 µM -0.646318087551107 0.260985427211663 no 2442 0.259036688171442 798 2994934 SGTC_1137 ixabepilone 100 µM -0.646858435067532 0.260817417440309 no 2443 0.2588617844339 812 154225 A novel microtubule stabilizer. SGTC_2989 9073649 71.4286 µM -0.647458450870718 0.260630920279705 no 2444 0.258667638439123 837 21367202 SGTC_9 0092-0002 10.449 µM -0.650176579498611 0.259786931043243 no 2445 0.257789083781575 820 759368 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.652874361870424 0.258950656052169 no 2446 0.256918639331353 806 1609 A potent and irreversible inhibitor of serine proteases. SGTC_280 3448-3607 3.04 µM -0.65320500793577 0.258848256250085 no 2447 0.256812061070023 802 626179 SGTC_974 1326-0144 138 µM -0.65422990733319 0.258530982066061 no 2448 0.25648184806288 829 5411856 SGTC_996 3970-0799 1.8 µM -0.65483397030547 0.258344078982441 no 2449 0.256287328277952 818 6615648 YGL040C HEM2 SGTC_1830 st055982 50.3 µM -0.656884919958269 0.257710017616242 no 2450 0.255627457667409 852 455313 An antimicrobial agent. SGTC_1587 estradiol valerate 56.1 µM -0.656996825310531 0.257675444772796 no 2451 0.255591478889706 836 13791 A steroid. SGTC_660 4031-1742 102 µM -0.65731191997123 0.25757811010227 no 2452 0.255490186768282 811 6738706 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.657630509647935 0.257479715216781 no 2453 0.255387792446457 814 94937 An inhibitor of serotonin biosynthesis. SGTC_854 0422-0053 192 µM -0.659174494102736 0.257003139819336 no 2454 0.254891861773006 825 3596728 SGTC_2257 7960413 200 µM -0.659612272217211 0.256868096177083 no 2455 0.25475133839879 814 2974689 YIL048W NEO1 SGTC_3334 9142812 21.919 µM -0.660300567552104 0.256655848907964 no 2456 0.254530482989843 811 45283678 SGTC_2443 5493264 126.67 µM -0.660877549957302 0.256477997213553 no 2457 0.254345422215859 830 5340055 SGTC_584 0986-0246 15.4 µM -0.661845678708934 0.256179721098428 no 2458 0.254035064070361 851 53315 YDR232W HEM1 SGTC_1714 st033236 13.627 µM -0.662350612871619 0.256024224954221 no 2459 0.253873273530735 827 2916566 SGTC_586 0957-0265 8.15 µM -0.663324779021205 0.25572436645601 no 2460 0.253561285004288 815 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2140 5586273 200 µM -0.663350747231934 0.255716375679846 no 2461 0.253552971126855 819 854421 SGTC_167 3672-0051 66.205 µM -0.664099648188984 0.255485984645358 no 2462 0.25331326765491 808 3237971 SGTC_186 3455-3465 67.277 µM -0.665489346328593 0.255058747018314 no 2463 0.252868777726305 825 755278 SGTC_292 k038-0015 474 µM -0.666457554783485 0.254761309839589 no 2464 0.252559342576917 831 46368540 SGTC_1901 st060216 58.6 µM -0.666939175948382 0.254613421718894 no 2465 0.252405492908533 815 688792 SGTC_1128 3448-9350 235 µM -0.668289551136871 0.254199011139809 no 2466 0.251974390915147 799 619386 SGTC_973 1325-0077 65.9 µM -0.668527547328957 0.2541260102366 no 2467 0.251898451857538 821 2835149 SGTC_1687 st020778 55.3625 µM -0.668946595264386 0.253997501810171 no 2468 0.251764772758412 808 4259299 SGTC_2261 9010538 184.68 µM -0.669183303876299 0.253924926020334 no 2469 0.25168927768425 854 6457250 SGTC_290 2043-6722 48.1 µM -0.671349220592291 0.253261353164141 no 2470 0.25099904283272 819 773758 YLR208W SEC13 SGTC_2179 6298986 200 µM -0.672813966393755 0.252813115689929 no 2471 0.250532825653373 814 738374 SGTC_502 l-744,832 89.3 µM -0.676284504602663 0.251752740555152 no 2472 0.249430014467693 847 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2532 xanthone 78.9 µM -0.676894736833678 0.251566535573089 no 2473 0.249236371848272 809 7020 An insecticide. SGTC_2174 5790901 200 µM -0.676993556133596 0.251536388906181 no 2474 0.249205021426933 836 786020 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.678996625565559 0.250925726994358 no 2475 0.248570000023888 829 551469 SGTC_1524 corynanthine 62.1 µM -0.680433813611449 0.250488065357535 no 2476 0.24811490840076 848 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_81 0411-0046 9.971 µM -0.680771441518637 0.250385307470109 no 2477 0.248008061612951 830 12925265 SGTC_250 brefeldin a 552.239 µM -0.680797969871308 0.250377234447367 no 2478 0.24799966740757 825 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2212 7123476 200 µM -0.683179798764752 0.249652966626126 no 2479 0.247246618003442 810 1085715 SGTC_2411 st077133 39.94 µM -0.684690581422045 0.249194144449409 no 2480 0.246769596840971 843 1403142 YNL221C POP1 SGTC_323 4013-0906 34.3 µM -0.685521947736154 0.248941851306158 no 2481 0.246507307915912 801 2910086 SGTC_2402 5553605 200 µM -0.686044547958503 0.24878332842864 no 2482 0.246342508527264 840 6758546 SGTC_1331 1472-0049 76.2 µM -0.686884163015463 0.248528756475342 no 2483 0.246077863788835 844 24051409 SGTC_1854 st056233 32.9 µM -0.688461911487336 0.248050757587933 no 2484 0.245580973924324 846 5393174 SGTC_1809 st050081 57.6 µM -0.688792035180094 0.247950804519038 no 2485 0.245477074295987 835 5036894 SGTC_1252 0493-0875 34.8 µM -0.688969263398839 0.247897153184319 no 2486 0.245421305111633 814 3960963 SGTC_1625 st003711 30.1 µM -0.689419350316791 0.247760928673334 no 2487 0.245279704885084 840 24207034 YER133W GLC7 SGTC_1955 wogonin 32.4 µM -0.689520816714931 0.247730224103667 no 2488 0.245247788974195 815 5281703 A flavanone. SGTC_2108 5365811 200 µM -0.690296950748022 0.247495426767533 no 2489 0.245003732524916 820 780283 SGTC_2870 9038528 12.99 µM -0.69045131406188 0.247448742706173 no 2490 0.244955208343978 832 6463316 SGTC_2492 derrusnin 100 µM -0.690459843412098 0.247446163313956 no 2491 0.244952527289454 848 1715307 Part of coumarin class of compounds. SGTC_1350 1495-0454 146 µM -0.695020130948988 0.246069129852507 no 2492 0.243521342895379 818 1069057 SGTC_1641 st009299 47.1 µM -0.697499150081785 0.245322288599785 no 2493 0.242745235550757 825 4046054 SGTC_3179 9107801 49.47 µM -0.69773212668625 0.245252163632175 no 2494 0.242672366375423 803 4818259 SGTC_1399 3562-5772 25 µM -0.698804564094979 0.244929503557235 no 2495 0.242337087922242 838 23847490 SGTC_744 1594-0068 283 µM -0.699407864609037 0.244748091318898 no 2496 0.242148587141812 844 668392 SGTC_811 0416-0114 265 µM -0.699912260989314 0.244596475055648 no 2497 0.241991049915572 833 6612453 SGTC_2985 9022375 71.43 µM -0.701640079663204 0.244077494530088 no 2498 0.241451824986048 844 4939335 SGTC_2645 abamectin 100 µM -0.7020956983004 0.243940740532668 no 2499 0.241309742420907 819 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.702794547302643 0.243731061268569 no 2500 0.241091897904588 848 689007 SGTC_1157 4092-0394 27.6 µM -0.709865906913331 0.241614888404656 no 2501 0.238893647009761 841 3659885 SGTC_281 1672-3440 14.9 µM -0.710550149998576 0.241410652691239 no 2502 0.238681521743755 829 6833000 SGTC_3324 9138759 60.749 µM -0.712763953916881 0.240750510357932 no 2503 0.237995917175023 853 45595710 SGTC_728 3030-5151 22.5 µM -0.713217948547114 0.240615253516755 no 2504 0.237855450708958 838 3125388 SGTC_631 k072-0230 41.5 µM -0.71403446773804 0.240372095294319 no 2505 0.237602933175255 852 5773147 SGTC_2273 7815444 169.05 µM -0.715089678512574 0.240058053441674 no 2506 0.237276815664727 868 2824616 SGTC_2003 4023581 200 µM -0.715980640261572 0.239793068098487 no 2507 0.237001651559868 853 16641307 SGTC_105 0111-0055 734.78 µM -0.717208943616352 0.23942801412435 no 2508 0.236622590803954 834 5179370 SGTC_1222 0366-0074 1.18 µM -0.718440189039309 0.239062390562576 no 2509 0.236242957097579 848 286520 SGTC_2568 diosmetin 100 µM -0.719136430599847 0.238855773839795 no 2510 0.236028431340727 853 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_734 2023-0417 80 µM -0.721359942305043 0.238196578759742 no 2511 0.235344042855766 853 3935732 SGTC_1832 st054113 55 µM -0.722051403145194 0.237991787662647 no 2512 0.235131437334147 831 1251267 SGTC_207 4185-0010 4.486 µM -0.722319963300127 0.237912273790301 no 2513 0.235048890954377 836 3761753 SGTC_1570 verbenone 133 µM -0.724661436048553 0.237219640391439 no 2514 0.234329879454602 846 29025 A natural terpanoid with antifungal properties. SGTC_540 1187-0821 17.3 µM -0.725075516676649 0.237097266150984 no 2515 0.234202851774266 841 847520 SGTC_831 k061-1017 217 µM -0.725513097662196 0.236967984499325 no 2516 0.234068656320756 859 1240153 SGTC_862 0452-0056 10.2 µM -0.725839868365113 0.236871466604943 no 2517 0.233968471469084 848 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1977 st070720 65.3 µM -0.725981598371893 0.236829610693773 no 2518 0.233925025757158 824 682188 SGTC_859 0439-0102 54.6 µM -0.726150925139971 0.236779610199201 no 2519 0.2338731264342 844 610143 SGTC_2859 9028643 45.46 µM -0.727385925958386 0.236415102495395 no 2520 0.233494786845026 813 17151580 SGTC_1618 st003135 44.5 µM -0.731000397215233 0.235350076482085 no 2521 0.232389455157447 866 1270615 SGTC_2863 9028737 58.44 µM -0.731986053719704 0.235060107024103 no 2522 0.232088540047059 847 6460917 SGTC_405 ebelactone b 50 µM -0.732103090293992 0.235025689245874 no 2523 0.23205282388427 848 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1483 3453-0561 55.9 µM -0.733444222599537 0.234631491733052 no 2524 0.231643767765404 865 4546991 SGTC_2199 6590217 200 µM -0.734378507593755 0.234357094622073 no 2525 0.231359040992523 808 703109 SGTC_2309 7664088 163.95 µM -0.734717394909402 0.234257608193977 no 2526 0.231255812101241 848 704922 SGTC_447 ml7 120 µM -0.737793364467855 0.233355672294815 no 2527 0.230320013083945 860 4216 Selective myosin light chain kinase inhibitor. SGTC_790 1575-0012 79.1 µM -0.737925237545934 0.233317047587765 no 2528 0.230279940868089 855 378741 YLR208W SEC13 SGTC_2616 abietic acid 100 µM -0.738178578237219 0.233242855816927 no 2529 0.230202969281767 858 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2583 asiatic acid 100 µM -0.738315745836826 0.233202691236002 no 2530 0.230161300151919 870 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1118 chelidonine 707.474 nM -0.739366313339621 0.232895197796241 no 2531 0.229842295977578 845 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1136 pergolide 1.05886 µM -0.740281482999374 0.232627517980814 no 2532 0.229564607133919 851 47811 A dopamine receptor agonist. SGTC_2177 5811945 192 µM -0.742688020719946 0.231924441762621 no 2533 0.228835292013462 850 5343475 SGTC_2065 5221596 34.26 µM -0.743317252552165 0.231740805405012 no 2534 0.228644814383079 848 788581 SGTC_138 0850-0259 40.9225 µM -0.744790930589542 0.231311041281781 no 2535 0.228199059236808 840 6813004 SGTC_896 0964-0007 44.5 µM -0.745099457066008 0.231221122979347 no 2536 0.228105798661799 837 6756758 SGTC_871 0574-0004 149 µM -0.745658014249315 0.231058384258259 no 2537 0.227937013996644 862 9551173 SGTC_2401 5128683 200 µM -0.747519384416007 0.23051652553242 no 2538 0.227375053136167 867 708373 SGTC_1795 st049545 62.3 µM -0.74886094000556 0.230126429518276 no 2539 0.226970512463576 823 5291882 SGTC_420 mitomycin C 81.9 mM -0.749069051060757 0.230065948328968 no 2540 0.226907793801748 838 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2057 5236571 38.335 µM -0.749342188579385 0.229986582662021 no 2541 0.226825492877764 854 54684039 YBR257W POP4 SGTC_625 k213-0058 121 µM -0.749503382893851 0.229939751562895 no 2542 0.226776930225195 854 3655420 SGTC_2201 6605497 169.863 µM -0.749769520778901 0.229862443336688 no 2543 0.22669676429614 854 670741 SGTC_259 usnic acid 108.925 µM -0.750583980032136 0.2296259481307 no 2544 0.226451532645571 878 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3209 9113616 49.47 µM -0.752896245034093 0.2289552771642 no 2545 0.225756132370615 851 16649353 SGTC_1814 st052110 31.539 µM -0.753301813914472 0.228837755580275 no 2546 0.225634284523187 850 674163 SGTC_3213 9129884 49.47 µM -0.75341039367888 0.22880629819836 no 2547 0.225601669473923 858 17190742 SGTC_2426 5582046 32.21 µM -0.754043700152497 0.228622867050089 no 2548 0.225411490861785 851 2251934 SGTC_1762 st045503 25.4615 µM -0.75415368855341 0.22859101838337 no 2549 0.225378471174758 853 4645554 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.754365414145013 0.228529717318121 no 2550 0.225314916612342 844 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2121 5257820 149.641 µM -0.754896527072738 0.228375984447387 no 2551 0.22515553487646 831 791256 SGTC_279 1273-0055 2.93 µM -0.756445766156295 0.227927882843431 no 2552 0.22469098860983 877 2847562 SGTC_2428 5615643 7.78 µM -0.756531049359492 0.22790322991921 no 2553 0.224665431855685 850 2253075 SGTC_1503 4585-0012 61.3 µM -0.758151741082199 0.227435019743365 no 2554 0.22418007386097 853 2922052 SGTC_1085 doxorubicin 7.67 µM -0.759852505169396 0.226944260213538 no 2555 0.223671377043111 854 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_569 4130-2812 160 µM -0.761438078288091 0.226487277735257 no 2556 0.223197725456167 860 743552 SGTC_3049 9092223 49.47 µM -0.763371082822136 0.225930864546896 no 2557 0.222621060256909 853 8623917 SGTC_2282 7944268 200 µM -0.76633513478748 0.22507916861169 no 2558 0.221738458847 865 2970414 SGTC_3059 1327-0034 3 µM -0.767856393547011 0.224642754840532 no 2559 0.221286253278591 853 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2711 st079103 59.1 µM -0.768803313456382 0.224371348079077 no 2560 0.221005040785646 868 54693780 SGTC_2125 5246583 200 µM -0.770608632039259 0.223854422600397 no 2561 0.22046947157598 857 835267 SGTC_657 3534-0529 86.7 µM -0.771058278358291 0.223725778590973 no 2562 0.220336194442381 879 1049549 SGTC_662 k832-1615 104 µM -0.771451163060616 0.223613408519607 no 2563 0.220219779519258 847 5878478 SGTC_2812 7970281 58.44 µM -0.772709078073513 0.223253844641013 no 2564 0.219847286438858 880 2233435 SGTC_3299 9121982 43.1275 µM -0.773667092941615 0.222980225458572 no 2565 0.219563842362717 855 17594604 YPL160W CDC60 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.774413548048688 0.222767162438533 no 2566 0.219343137195486 880 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2289 7946404 165.07 µM -0.774963721772032 0.222610198925039 no 2567 0.219180548396112 850 1246120 YPR165W RHO1 SGTC_2831 7999036 19.48 µM -0.77889603386062 0.221490155227958 no 2568 0.218020480233245 871 2988270 SGTC_895 0964-0006 13.7 µM -0.77889818816887 0.221489542498813 no 2569 0.218019845664221 876 6738897 SGTC_3345 9148410 3.559 µM -0.77951268840731 0.221314805677811 no 2570 0.217838883093169 846 4903596 SGTC_3330 9141424 71.43 µM -0.77957383199932 0.221297423445046 no 2571 0.21782088181644 859 27261020 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.779707009303713 0.221259565779487 no 2572 0.217781676073882 849 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2766 oltipraz 83.91 µM -0.783047883660075 0.220311084450452 no 2573 0.216799496886292 844 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_964 1287-0107 19.4 µM -0.78310923772329 0.220293687726767 no 2574 0.216781483469642 863 51516812 YPR165W RHO1 SGTC_3029 9088683 49.47 µM -0.784150578626812 0.219998539413816 no 2575 0.216475880117942 844 25236615 SGTC_1001 4048-4355 44.4 µM -0.784562191752414 0.219881938079631 no 2576 0.216355152382826 867 21824233 SGTC_394 menadione 8.33 µM -0.785672978095988 0.219567452754451 no 2577 0.216029548976056 876 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1261 0712-0010 12.7 µM -0.785704681938034 0.21955848057066 no 2578 0.216020259837024 867 2840123 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.786532890769061 0.219324172177046 no 2579 0.215777678899732 883 23847180 SGTC_565 1418-0001 44.5 µM -0.787200979391768 0.219135268117326 no 2580 0.215582112002463 879 2862145 SGTC_2860 9025725 38.96 µM -0.787378616747662 0.219085056370493 no 2581 0.215530130236689 878 40546248 SGTC_800 3448-7362 155 µM -0.787660242071274 0.219005464493154 no 2582 0.215447733520213 873 15991913 SGTC_864 0469-0573 172 µM -0.788010632103764 0.218906461815991 no 2583 0.215345243437543 898 689425 SGTC_3253 9135987 49.47 µM -0.788119282071949 0.218875768005994 no 2584 0.215313468759259 858 4182430 SGTC_775 4577-0580 57.3 µM -0.788436744767996 0.218786098415452 no 2585 0.215220642397452 867 2006902 SGTC_1742 st038235 28.8875 µM -0.788605995857592 0.218738300885234 no 2586 0.21517116272933 867 564103 YBR002C RER2 SGTC_2196 6573537 42.6665 µM -0.79045792290927 0.218215698266377 no 2587 0.214630193131502 882 2903087 SGTC_874 0599-0792 117 µM -0.791244425730751 0.217993969771969 no 2588 0.21440068579942 861 765305 SGTC_3251 9135047 49.47 µM -0.792686898608017 0.217587649943078 no 2589 0.213980132667717 853 17682963 SGTC_1989 st071868 50.2 µM -0.792881515204487 0.217532863273397 no 2590 0.213923428964673 860 16414057 SGTC_2588 indole-3-carbinol 100 µM -0.794422186581411 0.217099428775494 no 2591 0.213474846128975 869 3712 Induces cell cycle arrest. SGTC_205 1486-1330 71.903 µM -0.794521809207647 0.21707141929545 no 2592 0.213445858826201 872 4118834 SGTC_2183 6420625 130.508 µM -0.796491187820609 0.216518145850884 no 2593 0.212873297723149 874 2897619 SGTC_211 3455-0679 143.504 µM -0.79674722416072 0.216446275476337 no 2594 0.212798925704767 853 748649 SGTC_1064 honokiol 6.76 µM -0.798773245125583 0.215878050737351 no 2595 0.212210953461599 875 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1379 2144-0755 36.5 µM -0.800764835260799 0.215320326039914 no 2596 0.21163390006155 887 5392327 SGTC_2101 5377231 179.231 µM -0.800910057603625 0.215279690721912 no 2597 0.211591858565764 880 2844213 SGTC_2420 aureobasidin a 50 nM -0.803278369916241 0.214617630926478 no 2598 0.210906928529878 853 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_360 0957-0399 1.01 µM -0.804120344037867 0.214382543194823 no 2599 0.210663738195086 889 6752301 YPR165W RHO1 SGTC_2784 7567673 72.73 µM -0.80533162436313 0.214044604246208 no 2600 0.210314168592926 864 3471247 SGTC_671 0560-0003 407 µM -0.8054684554078 0.214006448818227 no 2601 0.210274701242108 854 3238678 SGTC_2823 7987624 58.44 µM -0.805512197112739 0.213994252249811 no 2602 0.210262085364764 872 2239440 SGTC_1280 0880-0253 10.1 µM -0.805680162530383 0.21394742194819 no 2603 0.210213645313607 875 6836607 SGTC_552 k242-0005 476 µM -0.808895189202979 0.213052193636769 no 2604 0.209287718169088 890 4088318 SGTC_38 0929-0051 58.268 µM -0.809343709683158 0.212927476469734 no 2605 0.209158735420139 887 1379719 SGTC_2130 NSC 7 2.4545 µM -0.810480671721715 0.212611519796515 no 2606 0.208831984661014 863 21448 SGTC_404 fumagillin 50 µM -0.81146344601359 0.212338631966447 no 2607 0.208549788313863 870 12015870 A methionine aminopeptidase binder. SGTC_953 1188-0045 9.7 µM -0.816480978691898 0.21094860278369 no 2608 0.207112549121099 877 6144426 SGTC_1897 st060201 15 µM -0.816538894224795 0.210932589396947 no 2609 0.207095993878115 888 611878 SGTC_1378 2093-0007 380 nM -0.817665412517844 0.210621253895463 no 2610 0.206774132650253 892 3618014 SGTC_148 3253-0744 288.01 µM -0.817831808701997 0.210575289900586 no 2611 0.206726616166953 876 6893655 SGTC_511 blebbistatin 171 µM -0.818144683496476 0.210488879728409 no 2612 0.206637288418467 889 3476986 A myosin inhibitor. SGTC_1744 st037937 38.9 µM -0.821178971304009 0.209651946348735 no 2613 0.20577216636312 884 1016152 SGTC_650 1328-0195 38 µM -0.821601489624248 0.20953556052784 no 2614 0.205651870610427 878 2780821 SGTC_1207 2099-0101 141 µM -0.822722002606272 0.209227090980832 no 2615 0.2053330500747 872 5837381 SGTC_1255 0566-0045 221 µM -0.824981376401215 0.208605914420699 no 2616 0.204691082004667 872 2788469 SGTC_1520 flindersine 88 µM -0.826066635182669 0.208307927841355 no 2617 0.204383146532558 885 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_761 k216-0224 480 µM -0.826461248554303 0.20819963855945 no 2618 0.204271245830029 907 1340404 SGTC_220 paclitaxel 373.376 µM -0.828755866386326 0.207570611030899 no 2619 0.203621283100467 856 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_296 1222-0039 74.9 µM -0.828833799998212 0.20754926669388 no 2620 0.203599229665655 880 5984176 SGTC_3144 9087057 49.47 µM -0.829058944862597 0.207487611653465 no 2621 0.203535526805708 868 17249618 SGTC_1421 4029-0249 71.4 µM -0.830020953290724 0.20722429138244 no 2622 0.203263468499907 881 2894095 SGTC_2955 9076254 12.21 µM -0.833323042790849 0.20632195046995 no 2623 0.202331282002213 864 16459619 SGTC_2549 cedrol 20.94 µM -0.836928966523212 0.20533924739866 no 2624 0.201316248564614 870 6708665 A sedative which affects the nervous system. SGTC_2353 9059630 146.67 µM -0.837974512457583 0.205054831140378 no 2625 0.201022509100367 887 4779114 SGTC_718 1130-0073 349 µM -0.838722832582502 0.204851412037147 no 2626 0.200812431272192 896 6740020 SGTC_2445 5742597 35.57 µM -0.839278244123397 0.204700509724243 no 2627 0.200656594384987 894 1774255 SGTC_2928 9011484 9.79 µM -0.842214143450421 0.203903940989027 no 2628 0.199834049230409 873 2994751 SGTC_180 1486-1293 102.781 µM -0.842245462993473 0.20389545333541 no 2629 0.199825285442446 879 4140536 SGTC_2834 9001755 58.44 µM -0.843492122666235 0.203557777296304 no 2630 0.199476634750356 898 2989575 SGTC_519 k048-0011 62.8 µM -0.843797548244541 0.203475099198331 no 2631 0.199391272898261 874 6836379 SGTC_1793 st048256 72.231 µM -0.844240771912142 0.203355155064755 no 2632 0.199267437676047 862 672022 SGTC_1834 st055981 52.8 µM -0.844501743682044 0.203284551243602 no 2633 0.199194544699139 862 471719 YDL150W RPC53 SGTC_1631 benzylvanillin 81.9 µM -0.845392462483171 0.203043684606901 no 2634 0.198945875764429 859 75506 SGTC_3201 9113999 49.47 µM -0.845428780090762 0.203033867279496 no 2635 0.198935740665016 893 16649224 SGTC_1320 1313-0481 95.3 µM -0.845790514041493 0.202936099311003 no 2636 0.198834809108736 880 6813365 YLR208W SEC13 SGTC_2347 9049783 174.81 µM -0.846635667316436 0.202707784370378 no 2637 0.198599113503945 908 6467988 YPL169C MEX67 SGTC_3150 9097574 49.47 µM -0.84725564698922 0.202540396863209 no 2638 0.198426321310098 869 17217476 SGTC_1175 0741-0056 27.6 µM -0.847436390323067 0.20249161376512 no 2639 0.198375964099994 894 765927 SGTC_1246 0422-0085 105 µM -0.847781506492537 0.202398485523768 no 2640 0.198279832115652 887 264295 SGTC_1117 retinoic acid 1.10837 µM -0.850102063138427 0.201772957814024 no 2641 0.19763417234348 888 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_3328 9140624 29.0385 µM -0.85074902364747 0.201598770157324 no 2642 0.197454392157587 885 4904392 SGTC_1143 3454-2408 5.08 µM -0.852118831968665 0.201230260364602 no 2643 0.197074070380551 849 X1143 SGTC_2796 7949634 45.45 µM -0.853495844530435 0.20086021983703 no 2644 0.196692195549153 895 2971588 SGTC_2995 9067767 71.4286 µM -0.854251940606338 0.200657210140613 no 2645 0.196482704795984 891 11673567 SGTC_1620 st003704 16.5 µM -0.854272730208687 0.20065162993074 no 2646 0.196476946553104 876 2834414 SGTC_1422 4031-0024 15.5 µM -0.857203734419483 0.199865841627334 no 2647 0.195666149494179 912 782427 SGTC_2 0422-0095 29 µM -0.857230938824725 0.199858556934988 no 2648 0.195658633527838 862 6790840 SGTC_2398 5228213 48.84 µM -0.857602550247931 0.199759064228909 no 2649 0.195555983185811 890 80771 YMR134W ERG29 SGTC_3266 9136860 49.47 µM -0.857963653854565 0.199662413362681 no 2650 0.195456266755946 872 4871271 YPR165W RHO1 SGTC_350 k064-0020 19.8 µM -0.858494327992688 0.199520427315844 no 2651 0.195309780571441 871 2790705 SGTC_2524 avocatin b 10.57 µM -0.858902477174496 0.199411265143072 no 2652 0.195197161312354 857 6710748 SGTC_1913 st060213 96.1 µM -0.862728773958641 0.198389646612402 no 2653 0.194143304091827 901 688959 SGTC_1798 st045719 60.953 µM -0.862938439472596 0.198333757490245 no 2654 0.194085657333201 866 3980186 SGTC_3284 9108171 64.8615 µM -0.863928222379138 0.198070046065624 no 2655 0.193813661014861 855 8687505 SGTC_2520 obtusaquinone 4.71 µM -0.863991273871513 0.198053254206049 no 2656 0.193796342087416 887 5967872 SGTC_813 k007-0158 173 µM -0.864011795968208 0.198047788951213 no 2657 0.193790705299788 882 6523916 SGTC_2920 7982904 15.77 µM -0.865328970371993 0.197697201792752 no 2658 0.193429127175097 880 6456808 SGTC_829 1635-0120 117 µM -0.866054614417488 0.197504220289542 no 2659 0.193230106259896 877 285054 SGTC_746 1095-0025 46.6 µM -0.866738354720169 0.197322487142301 no 2660 0.193042692611248 887 6749286 SGTC_2462 5162487 171.77 µM -0.867090319269948 0.197228976998307 no 2661 0.19294626219324 886 2259986 SGTC_3153 9100258 49.47 µM -0.867734091509794 0.197058008598076 no 2662 0.192769959124747 903 25236848 SGTC_3235 9132602 49.47 µM -0.867908877315634 0.197011605727786 no 2663 0.19272210938592 887 4912240 SGTC_683 panaxydol 45 µM -0.868102496754478 0.196960210547304 no 2664 0.192669112184589 873 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1361 1608-0041 5.61 µM -0.868678510140214 0.196807359061168 no 2665 0.19251149939447 884 X1361 SGTC_3124 9127567 49.47 µM -0.86916708118535 0.196677767680297 no 2666 0.192377874985252 896 17592030 SGTC_941 3237-0776 460 µM -0.870147350010175 0.196417911504288 no 2667 0.192109942114783 892 760008 SGTC_2474 5321570 43.32 µM -0.87017270094062 0.196411194072525 no 2668 0.192103016078635 902 2841384 SGTC_595 3909-8003 73.7 µM -0.871338174048843 0.196102520029257 no 2669 0.191784766369912 901 699517 SGTC_277 nystatin 15.5 µM -0.87339460418974 0.195558595232296 no 2670 0.191224015523153 912 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2014 4013930 200 µM -0.873977401310574 0.195404612431029 no 2671 0.191065280390339 898 64556 SGTC_3218 9131285 49.47 µM -0.874523621792347 0.195260360548746 no 2672 0.190916580934739 894 17156417 SGTC_1450 4112-4260 37.6 µM -0.875973608496386 0.194877746181647 no 2673 0.190522190628908 888 1633175 SGTC_266 formosanin C 406 nM -0.878507725155349 0.194210153379206 no 2674 0.189834123634584 871 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_3164 9100705 49.47 µM -0.879036973908526 0.194070903048564 no 2675 0.189690614369643 858 17174235 SGTC_4 0960-0234 25.671 µM -0.87985899731571 0.19385474159481 no 2676 0.189467849693295 869 6821112 SGTC_1466 k213-0079 57.5 µM -0.880837649417704 0.193597584088539 no 2677 0.189202849357964 914 3657981 SGTC_2771 fluoxetine 41.05 µM -0.882947269571397 0.19304395350409 no 2678 0.188632381139897 883 3386 A selective serotonin reuptake inhibitor. SGTC_3219 9131112 49.47 µM -0.883525575583533 0.192892356832965 no 2679 0.188476185185647 876 17612988 YMR079W SEC14 SGTC_104 0074-0074 590.992 µM -0.883863825166749 0.192803722073527 no 2680 0.18838486358596 892 3943124 SGTC_2269 7935389 174.42 µM -0.884950335010506 0.19251918191992 no 2681 0.18809170920312 887 97605 SGTC_727 3032-0951 202 µM -0.885550339000688 0.192362160217871 no 2682 0.187929941125564 905 3652836 SGTC_3327 9140648 26.9345 µM -0.887515525631618 0.191848417287643 no 2683 0.187400705574072 909 8029710 SGTC_2716 st080858 38.6235 µM -0.890131736082883 0.191165787331847 no 2684 0.18669757694931 879 5296050 SGTC_2187 6125751 200 µM -0.893548426051021 0.190276539347557 no 2685 0.185781775559343 903 874498 SGTC_2431 5490079 200 µM -0.896840174885678 0.189422216971348 no 2686 0.184902103460977 921 5722345 SGTC_1509 1326-1131 80 µM -0.89873201218147 0.188932289914245 no 2687 0.184397710699601 864 768313 SGTC_3200 9114385 49.47 µM -0.899315129838557 0.188781438105508 no 2688 0.18424241535504 889 17018030 YLR208W SEC13 SGTC_2724 maprotiline 69.64 µM -0.899436979389128 0.188749925158012 no 2689 0.184209974781323 894 4011 A tricyclic antidepressant. SGTC_2456 5770359 74.46 µM -0.901155322248048 0.188305869586004 no 2690 0.183752870973742 909 3118787 SGTC_381 3461-2219 42.7 µM -0.904125376635331 0.187539866924752 no 2691 0.182964461854222 934 2883159 SGTC_2150 5556613 200 µM -0.904718330174095 0.187387169988559 no 2692 0.182807313849561 925 743190 SGTC_2211 7117706 200 µM -0.906261969711836 0.186990013727728 no 2693 0.182398604818892 893 822771 SGTC_1824 st053723 68.6 µM -0.906349783486315 0.186967436172293 no 2694 0.182375371563629 899 675225 SGTC_1871 st057448 67.3 µM -0.908488078428326 0.186418185777567 no 2695 0.181810204763304 897 691747 SGTC_2126 5251174 33.877 µM -0.90989914541323 0.186056281843942 no 2696 0.181437850260688 918 790722 SGTC_2363 9053361 176 µM -0.911804365422074 0.185568331403315 no 2697 0.180935855967258 909 6469797 YMR079W SEC14 SGTC_1039 k821-0043 94 µM -0.91280408657275 0.18531260841027 no 2698 0.180672794334399 895 15992768 SGTC_1702 st027038 51 µM -0.913172680737168 0.185218379351063 no 2699 0.18057586484654 907 5521182 SGTC_2075 5212009 200 µM -0.915359559414716 0.184659928099787 no 2700 0.1800014506633 892 780898 SGTC_2221 6807166 181.081 µM -0.915512029765561 0.184621031659466 no 2701 0.179961445030025 887 674925 SGTC_1505 k297-0037 20.6 µM -0.916016025396363 0.184492494486652 no 2702 0.179829244863512 888 4089396 SGTC_3075 9116269 49.47 µM -0.917044858354168 0.184230277591854 no 2703 0.179559567087949 892 17015205 YNL244C SUI1 SGTC_856 0433-0016 11.3 µM -0.918733777910162 0.183800328730277 no 2704 0.17911741879271 907 3911780 SGTC_2350 9023895 38.85 µM -0.92000166932047 0.18347797223147 no 2705 0.178785943444136 887 2997209 SGTC_2845 9003024 42.97 µM -0.921155400592551 0.183184946947399 no 2706 0.178484649727333 892 2990173 SGTC_1139 k015-0024 46.9 µM -0.92209703008357 0.182946007842481 no 2707 0.178238982988715 918 2766652 SGTC_65 0798-0905 34.986 µM -0.922907567164218 0.18274048935643 no 2708 0.178027688401501 936 3602145 SGTC_3083 9117465 49.47 µM -0.924702312791492 0.182285929703048 no 2709 0.177560388030976 907 16420915 SGTC_522 1273-0010 11.6 µM -0.926607472010015 0.181804179174613 no 2710 0.177065186992438 875 5705015 SGTC_1174 0739-0097 51.1 µM -0.927779437511509 0.181508224642518 no 2711 0.176760996190765 923 728447 SGTC_1022 4477-0945 21.3 µM -0.927850853638913 0.18149019979787 no 2712 0.176742470384145 885 4648966 SGTC_1179 1021-1431 9.29 µM -0.928560800312578 0.181311076018581 no 2713 0.176558372371175 935 2840958 SGTC_3178 9107506 49.47 µM -0.929911082363041 0.180970697434952 no 2714 0.176208562243485 903 8897194 SGTC_2129 girgensonine 121.053 µM -0.930066903315479 0.18093144393533 no 2715 0.176168222817195 911 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_206 4546-0025 72.014 µM -0.931590002363104 0.180548034791719 no 2716 0.175774225919691 911 6620745 YIL048W NEO1 SGTC_3252 9135871 49.47 µM -0.931912669922115 0.180466875269498 no 2717 0.175690829635513 919 17682838 SGTC_1032 k061-1018 98.7 µM -0.932115506476963 0.18041586816719 no 2718 0.175638417568964 933 4005393 SGTC_3260 9137109 49.47 µM -0.933555871181466 0.180053921317564 no 2719 0.175266518732642 888 17478346 SGTC_1735 st034310 56.75 µM -0.937570728881405 0.179047443000633 no 2720 0.174232529933466 867 871153 SGTC_2318 6029776 164 µM -0.93759720566676 0.179040817347975 no 2721 0.174225723978606 924 818325 SGTC_670 4204-0025 119 µM -0.937690105913979 0.179017570852851 no 2722 0.174201844965485 919 719039 SGTC_75 0159-0059 199.013 µM -0.939007089523825 0.178688225423563 no 2723 0.17386355220721 906 5377270 SGTC_2536 dehydroabietamide 32.04 µM -0.940228176529682 0.17838320247189 no 2724 0.173550265884695 919 3983547 SGTC_1760 st045453 10.4495 µM -0.940652015832403 0.178277405744453 no 2725 0.173441608240644 912 3323419 YIL048W NEO1 SGTC_545 4218-0007 221 µM -0.941530845231806 0.178058162606794 no 2726 0.173216444985664 933 2840508 SGTC_1145 3546-0597 10.2 µM -0.942937210152393 0.177707668085917 no 2727 0.172856510309459 905 875334 SGTC_539 4859-0462 2.54 µM -0.943075405003542 0.17767325064398 no 2728 0.17282116747487 900 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1272 0839-0021 27 µM -0.945221064202143 0.177139413701172 no 2729 0.172273013839396 935 5027250 SGTC_1748 st037455 53.6035 µM -0.952572929328314 0.175317973864766 no 2730 0.170403249264882 915 580690 SGTC_264 promethazine 12.5 mM -0.95354444806123 0.175078169520138 no 2731 0.17015714345074 917 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1066 ketoconazole 628 nM -0.953734147073424 0.17503136955171 no 2732 0.170109115354334 907 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_449 xestospongin c 11.1929 µM -0.955071150923039 0.174701747221684 no 2733 0.169770858439997 911 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_994 3910-0338 138 µM -0.957887496366946 0.174008701268126 no 2734 0.169059746063135 907 3479481 SGTC_961 1252-1571 372 µM -0.959335442678807 0.173653072101934 no 2735 0.168694892900031 931 6813498 SGTC_3297 9117502 71.43 µM -0.959856714892516 0.1735251560533 no 2736 0.168563666833169 913 7453720 SGTC_1655 st012546 55.1 µM -0.964731542307938 0.172331816075912 no 2737 0.167339646127404 931 720985 YLR208W SEC13 SGTC_179 1273-0063 6.77 µM -0.965747696437011 0.172083726224831 no 2738 0.16708522318217 942 3108139 SGTC_251 melphalan 456.522 µM -0.96733320829763 0.171697085617925 no 2739 0.166688743890654 927 460612 A DNA alkylator. SGTC_108 0509-0257 621.132 µM -0.967829590937056 0.171576152622915 no 2740 0.166564741398495 910 536624 SGTC_2164 5685496 200 µM -0.968611202414011 0.171385840080914 no 2741 0.166369605958512 952 759046 SGTC_3305 9127027 53.8275 µM -0.968904303671819 0.171314508419291 no 2742 0.166296469001006 918 41905295 SGTC_3287 9117173 37.0625 µM -0.97047838372033 0.170931751388765 no 2743 0.16590404727465 885 2789709 SGTC_937 3122-0005 46.7 µM -0.9716489130754 0.170647477687593 no 2744 0.16561261998934 897 759535 SGTC_3119 9125183 49.47 µM -0.972009665734282 0.170559926669095 no 2745 0.165522869996223 883 22695334 SGTC_2205 7238770 200 µM -0.972103834545408 0.170537077586224 no 2746 0.165499447350069 919 279867 SGTC_717 1532-0246 73.2 µM -0.973496213369031 0.17019946010092 no 2747 0.165153370636351 920 9561992 SGTC_687 k029-0044 34.9 µM -0.973728985278425 0.170143060471089 no 2748 0.16509556075236 917 5829338 SGTC_11 0438-0307 1.3 µM -0.975993803221536 0.169594930123415 no 2749 0.164533767590051 941 4011476 SGTC_561 1550-0330 72.9 µM -0.977108901268587 0.169325471191426 no 2750 0.164257620735143 927 6812934 SGTC_992 3909-8734 162 µM -0.977198058953066 0.169303938468524 no 2751 0.164235554391344 932 4288319 SGTC_3045 9092950 49.47 µM -0.978037676220161 0.169101246365855 no 2752 0.164027845140036 925 44120432 SGTC_1245 0418-0076 17.2 µM -0.979105651806395 0.168843651523427 no 2753 0.163763889680798 962 6790114 SGTC_1141 3253-0389 52.6 µM -0.979582091841595 0.168728815942791 no 2754 0.163646224148503 927 5402031 SGTC_3315 9136395 68.55 µM -0.980463800491475 0.168516431544247 no 2755 0.163428614979619 938 16876844 SGTC_199 4063-0024 41.6 µM -0.980811796919046 0.168432654115427 no 2756 0.163342779843496 918 306215 SGTC_20 0481-0013 4.944 µM -0.981904318945903 0.168169812011351 no 2757 0.163073493918131 919 182045 SGTC_1523 st012844 44.7 µM -0.983225229833597 0.167852376066025 no 2758 0.162748300043963 936 4274103 SGTC_2899 9053889 58.44 µM -0.984580287347321 0.167527135253843 no 2759 0.162415138222216 909 6470052 SGTC_1846 st056244 14.8 µM -0.985312695900479 0.167351511738351 no 2760 0.162235249192097 930 5393182 SGTC_1271 0832-2808 169 µM -0.985372434738648 0.16733719225737 no 2761 0.162220582283421 920 3663794 SGTC_1479 0549-0158 134 µM -0.987608181979721 0.166801848415142 no 2762 0.16167228880718 936 5440202 SGTC_2175 5807670 165.306 µM -0.989148530340931 0.166433659614322 no 2763 0.161295238184744 877 241186 SGTC_643 k048-0106 28.4 µM -0.991119786923359 0.165963237048637 no 2764 0.160813546083874 932 6763920 SGTC_894 0960-0238 55.9 µM -0.995082238784162 0.165020236021985 no 2765 0.159848134119476 950 6741907 YDL195W SEC31 SGTC_1602 st001878 87.6 µM -0.995457734657756 0.1649310542325 no 2766 0.159756845349785 930 595405 YLR310C CDC25 SGTC_807 1315-0151 48 µM -0.997055806048511 0.164551854957344 no 2767 0.159368711408265 946 4011080 SGTC_1861 st057647 17.4 µM -1.00066431185069 0.163697688682536 no 2768 0.158494563303715 926 688668 SGTC_2764 methyldopa 94.69 µM -1.0015527086092 0.163487839397927 no 2769 0.158279835588302 933 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.00336625474412 0.163060002045155 no 2770 0.15784208979584 908 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2505 galangin 7.89 µM -1.00478648745993 0.162725460645963 no 2771 0.157499835912872 931 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2078 5212016 200 µM -1.00498819978656 0.162677982745468 no 2772 0.157451265976958 918 1899708 SGTC_2491 paeonol 100 µM -1.00798780729634 0.161973015657459 no 2773 0.156730157809635 948 11092 Increases levels of cortical cytochrome oxidase. SGTC_1291 0993-0025 5.79 µM -1.01000748149498 0.161499475011084 no 2774 0.156245852827692 937 4353356 SGTC_2953 9074162 66.49 µM -1.0137312388941 0.160628757254784 no 2775 0.155355506810459 878 16451992 SGTC_2847 9005661 71.43 µM -1.01522795488106 0.160279649019726 no 2776 0.154998588944412 910 2991449 SGTC_2430 5571206 200 µM -1.01672897710822 0.159930034781629 no 2777 0.154641188449352 928 1731771 SGTC_3265 9137266 49.47 µM -1.01764726759243 0.159716395015194 no 2778 0.154422807851541 898 17224265 SGTC_3231 9132313 49.47 µM -1.01801599906721 0.159630662412816 no 2779 0.154335176439501 930 4905967 SGTC_102 gallobenzophenone 83.616 µM -1.02186863740306 0.158736699069 no 2780 0.153421539016616 906 70837 SGTC_3093 9117344 49.47 µM -1.02302975687117 0.158467918646966 no 2781 0.1531468883007 915 24824913 SGTC_1900 st060200 72.8 µM -1.02359966008094 0.158336104529839 no 2782 0.153012202924727 934 688945 SGTC_533 1222-0222 6.71 µM -1.02426689873671 0.158181868932348 no 2783 0.152854614051431 951 3982874 SGTC_27 0485-0001 32.618 µM -1.02568759370478 0.157853796678927 no 2784 0.152519432027788 897 2054479 SGTC_2277 7947813 106.88 µM -1.02634360992821 0.157702457844888 no 2785 0.152364824012579 949 1246798 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.02679961835814 0.157597315728097 no 2786 0.152257414567221 866 4000243 SGTC_713 1488-1073 324 µM -1.03180226389637 0.156446877854281 no 2787 0.1510823792607 952 3312542 SGTC_1214 0358-0031 63.7 µM -1.03271864944566 0.156236741242762 no 2788 0.150867791708181 967 4301366 SGTC_1061 3448-9325 110 µM -1.03383342044748 0.155981363608645 no 2789 0.150607022417838 923 723482 SGTC_3034 9090421 49.47 µM -1.03517987948126 0.155673276709398 no 2790 0.150292456718497 915 17173761 SGTC_2035 5154463 94.595 µM -1.03549135283591 0.155602064852269 no 2791 0.150219751341461 941 2769623 SGTC_1403 3909-7815 62.9 µM -1.03786044675603 0.155061124508833 no 2792 0.149667515130862 919 6615483 SGTC_307 1501-1223 22.3 µM -1.03952713279599 0.154681311425241 no 2793 0.149279822976494 938 2830329 SGTC_496 calpeptin 138 µM -1.0402071283558 0.15452652721998 no 2794 0.149121840216646 929 73364 A calpain inhibitor. SGTC_1825 st052143 62.6 µM -1.04223997357954 0.15406441088739 no 2795 0.148650217225654 953 674173 SGTC_1636 st007707 68.9 µM -1.04264088093436 0.153973382710106 no 2796 0.148557323991815 950 403051 SGTC_3073 9114972 49.47 µM -1.04510108244809 0.153415560100099 no 2797 0.147988126922217 916 41905075 SGTC_2207 7258803 200 µM -1.04515599056055 0.153403125603508 no 2798 0.147975439948906 937 3666799 SGTC_546 peri-Naphthalide 147 µM -1.04642757507662 0.153115349203635 no 2799 0.14768183348902 917 223824 A penicillin ester. SGTC_3215 9129942 49.47 µM -1.04730628691929 0.152916694284412 no 2800 0.147479168704942 961 17682944 SGTC_1388 3346-4487 254 µM -1.04775253559901 0.152815874002942 no 2801 0.147376317954929 972 3345614 SGTC_2642 cholecalciferol 100 µM -1.04779755159393 0.152805706056394 no 2802 0.14736594540315 918 9821465 A vitamin D precursor, similar to steriods. SGTC_694 1315-0438 43.2 µM -1.04797027686298 0.152766696058407 no 2803 0.147326150716184 933 6793154 SGTC_1041 0206-0046 107 µM -1.04815012369311 0.152726084675867 no 2804 0.147284722925833 958 50494 SGTC_766 1391-0721 126 µM -1.04872029243265 0.152597381676178 no 2805 0.14715343594419 970 1020919 YIL115C NUP159 SGTC_716 1683-5115 658 µM -1.04941595043332 0.15244044973095 no 2806 0.146993360109727 936 723597 SGTC_1313 1220-0047 237 µM -1.04946043319456 0.152430418608182 no 2807 0.146983128285002 936 3528706 SGTC_886 0866-0150 153 µM -1.05325319396401 0.1515767398694 no 2808 0.146112482321161 939 271463 SGTC_2938 9059746 27.26 µM -1.05355002713234 0.151510062698497 no 2809 0.146044489355828 960 6471769 SGTC_1445 4239-0156 97.7 µM -1.05459378959084 0.151275758830254 no 2810 0.145805572671453 967 4008346 SGTC_458 nppb 133 µM -1.05588589128947 0.150986041769237 no 2811 0.145510175347905 961 4549 A chloride channel blocker. SGTC_2052 5265182 7.135 µM -1.05622640532367 0.15090975270118 no 2812 0.145432394866785 937 1239884 SGTC_1736 st036774 51 µM -1.05624034436953 0.150906630331646 no 2813 0.145429211494976 943 1272247 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.05681804538525 0.150777262161564 no 2814 0.145297318498695 958 4174840 SGTC_979 1426-2828 121 µM -1.05780918068724 0.150555483146528 no 2815 0.145071223221886 958 747872 SGTC_1309 pyrazolanthrone 13.4 µM -1.06181045986992 0.149662356650355 no 2816 0.144160870158462 948 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_183 3914-0051 30.55 µM -1.06294393361361 0.149409997548795 no 2817 0.143903688899174 938 1596232 SGTC_204 PMA1.184 62.41 µM -1.06443830232367 0.149077722344672 no 2818 0.143565095081538 946 2252213 YGL008C PMA1 SGTC_1893 st059353 36.1 µM -1.06653441643176 0.14861248045568 no 2819 0.143091064714374 985 3112488 SGTC_875 0709-0210 25.7 µM -1.06767501985041 0.148359726675374 no 2820 0.142833565170039 958 6251364 SGTC_742 0kpi-0133 140 µM -1.06787003962953 0.148316539766177 no 2821 0.142789569405702 956 2728852 SGTC_3081 9117243 49.47 µM -1.06805290880946 0.148276051233996 no 2822 0.142748323096074 951 45595589 SGTC_3095 9117207 49.47 µM -1.06903231790827 0.148059328977584 no 2823 0.142527553580005 944 17015229 SGTC_1813 st051246 8.6015 µM -1.06946275687849 0.147964149144668 no 2824 0.142430601012052 920 5291959 SGTC_1658 st012944 20 µM -1.07178520777469 0.147451309268415 no 2825 0.141908259311905 948 24207260 SGTC_1568 digitonin 820 nM -1.07308246038939 0.147165371053772 no 2826 0.14161705991452 964 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2808 7946468 45.46 µM -1.07354909086369 0.147062608124585 no 2827 0.141512412602837 959 2970879 SGTC_3111 9122088 49.47 µM -1.0739840768558 0.146966857391105 no 2828 0.141414909133703 917 16876704 SGTC_1254 0550-0035 264 µM -1.07476923843831 0.146794130571151 no 2829 0.141239027997621 953 15121435 SGTC_622 1348-1566 26.3 µM -1.07572582501656 0.14658387626287 no 2830 0.141024947062298 936 7340407 SGTC_2851 9015922 71.43 µM -1.07622380933459 0.14647450112529 no 2831 0.140913586955963 920 2996893 SGTC_1583 clindamycin 39.6 µM -1.07625866728506 0.146466847126841 no 2832 0.140905794195863 961 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2879 9041815 71.43 µM -1.07793803671259 0.146098414547514 no 2833 0.140530704676098 936 4942971 SGTC_2644 guaiazulene 100 µM -1.07897149381078 0.145871996733857 no 2834 0.140300217782338 932 3515 A coloring agent. SGTC_3069 9117009 49.47 µM -1.07977187534536 0.145696805048282 no 2835 0.140121889098371 941 41904981 SGTC_310 1273-0058 1.06 µM -1.07977598919315 0.145695904953352 no 2836 0.140120972912128 890 2734232 SGTC_2308 7584454 197.62 µM -1.08013375522105 0.145617641346944 no 2837 0.140041311171834 952 893577 SGTC_816 0325-0417 81.3 µM -1.08126400808069 0.145370577044492 no 2838 0.139789846352697 932 68101 SGTC_2229 7354935 190 µM -1.08285826664406 0.145022564421514 no 2839 0.139435669139906 953 318112 SGTC_2254 7938975 95.19 µM -1.0845233448928 0.144659691676711 no 2840 0.1390664109861 969 2969277 SGTC_2296 7971656 126.45 µM -1.0848846883046 0.144581024454682 no 2841 0.138986365195669 941 666570 SGTC_945 3381-0768 11.3 µM -1.0868241417399 0.144159283158494 no 2842 0.138557268166947 955 1126236 YIL048W NEO1 SGTC_2767 sibutramine 71.45 µM -1.0881653677802 0.143868114223591 no 2843 0.138261055255927 950 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_3076 9116187 49.47 µM -1.08845696191204 0.143804864119589 no 2844 0.138196713182485 947 27241210 SGTC_25 0118-0223 35.662 µM -1.08915462550466 0.143653609054189 no 2845 0.1380428522021 953 5333628 SGTC_3139 9095020 49.47 µM -1.08982854637683 0.143507603447443 no 2846 0.137894338352662 885 25236292 SGTC_2916 7875993 68.79 µM -1.09031286085876 0.143402738133081 no 2847 0.137787675937236 928 1299250 SGTC_2389 9091542 195.52 µM -1.09083644230067 0.143289428826149 no 2848 0.137672428951917 939 3626624 YOL127W RPL25 SGTC_3018 9082602 49.47 µM -1.09405649145295 0.142593901125429 no 2849 0.1369651014318 927 17332089 SGTC_2263 7948595 193.29 µM -1.09595463710699 0.14218497466024 no 2850 0.136549313387801 933 2971371 SGTC_2550 chrysin dimethyl ether 71.87 µM -1.09609010869656 0.142155819749324 no 2851 0.136519671428746 914 88881 An O-methylated flavonoid and antioxidant. SGTC_2685 mycophenolic acid 18.85 µM -1.09661704093062 0.142042456866278 no 2852 0.136404417491865 940 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_485 niflumic acid 177 µM -1.10427623681296 0.140401585534578 no 2853 0.13473666387379 971 4488 A COX2 inhibitor. SGTC_2959 9079155 11 µM -1.10438009483996 0.140379424271302 no 2854 0.134714145851943 943 16189457 SGTC_1101 ebselen 5.29 µM -1.10487877154632 0.140273049539468 no 2855 0.134606061022192 961 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2876 9059903 25.97 µM -1.10527527644197 0.14018850856681 no 2856 0.134520163735477 946 6916095 SGTC_2551 apiole 73.87 µM -1.10706855818137 0.139806585480419 no 2857 0.134132144103721 934 10659 A possible DNA adduct former. SGTC_2149 5554786 194.827 µM -1.10904980511125 0.139385453710011 no 2858 0.13370434845852 969 745063 YPR165W RHO1 SGTC_3063 1327-0034 4 µM -1.10960476569166 0.139267646751552 no 2859 0.133584688380304 936 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2827 7993847 71.43 µM -1.1098214930192 0.139221658304335 no 2860 0.133537977839103 932 2985692 SGTC_3311 9131146 2.8755 µM -1.11056677785427 0.139063591494948 no 2861 0.133377434739921 952 4900406 YPR165W RHO1 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.11415219045437 0.138304872320494 no 2862 0.132606950947014 960 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_269 exalamide 29 µM -1.11416943668661 0.13830122962948 no 2863 0.13260325225959 955 3316 A derivative of salicylamide. SGTC_1077 5-fluorocytosine 377 nM -1.1158889831665 0.137938361136359 no 2864 0.132234829055755 960 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2341 7987486 176.74 µM -1.11624804011396 0.137862672932014 no 2865 0.132157988081972 938 1258686 SGTC_2751 anetholtrithion 17.25 µM -1.11668850050064 0.137769863813342 no 2866 0.132063768194143 966 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2208 7283366 200 µM -1.11783248904229 0.137529013932067 no 2867 0.131819271416466 938 898663 SGTC_2797 7859098 81.82 µM -1.11815103837523 0.137461999270713 no 2868 0.131751245685478 932 972681 SGTC_1875 nocodazole 6 µM -1.12233652251697 0.136583550866852 no 2869 0.130859691469034 959 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2840 9008771 71.43 µM -1.12276825859124 0.136493157113351 no 2870 0.130767964723843 931 2992978 SGTC_1717 st033143 58.0435 µM -1.12468042162631 0.136093294349386 no 2871 0.130362240502951 968 674616 SGTC_1729 st035615 45.989 µM -1.12482886741286 0.136062285621134 no 2872 0.130330779625769 942 17385451 SGTC_357 1325-0123 420 µM -1.12681926780476 0.135646979531531 no 2873 0.129909451176189 986 1098503 SGTC_3004 9076122 71.4286 µM -1.12720816452714 0.135565935981858 no 2874 0.129827239665621 977 44782551 SGTC_1055 3448-0672 86 µM -1.12758367365873 0.135487713806543 no 2875 0.129747892440316 958 748378 SGTC_2717 st081029 62.2815 µM -1.128411396798 0.135315400330927 no 2876 0.129573108430775 942 5292846 SGTC_359 0081-0058 15.9 µM -1.12977725613338 0.135031387495392 no 2877 0.129285047060578 949 3494159 SGTC_2997 9067075 71.4286 µM -1.13073483908935 0.134832514420215 no 2878 0.129083356535968 941 27209819 SGTC_2647 atorvastatin 60.16 µM -1.13108712293522 0.134759401872015 no 2879 0.129009211814734 933 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2303 7774051 200 µM -1.13460489628926 0.134030819618071 no 2880 0.128270450362556 954 2953184 SGTC_3090 9117696 49.47 µM -1.13465919782775 0.134019594228802 no 2881 0.128259069660879 929 7923821 SGTC_1307 1187-1599 12.2 µM -1.13773450398076 0.13338491108963 no 2882 0.127615680558777 958 1538471 SGTC_2176 5809774 33.9695 µM -1.14056032629886 0.132803542119563 no 2883 0.127026467506784 917 2870539 SGTC_3342 9147791 14.508 µM -1.1441689878151 0.132063656553176 no 2884 0.126276780842044 953 1838168 SGTC_1235 benzylparaben 21.5 µM -1.14755546603232 0.131371915261248 no 2885 0.125576061610485 986 7180 SGTC_608 k048-0125 159 µM -1.14812415807182 0.131255996775446 no 2886 0.125458656268298 962 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1804 st050076 49.1 µM -1.14895865124388 0.131086027023751 no 2887 0.1252865155352 981 3895976 SGTC_3232 9132874 49.47 µM -1.14996402608775 0.130881454077343 no 2888 0.125079344123653 954 3784940 SGTC_1397 3532-0190 20.1 µM -1.15194913814678 0.130478173078815 no 2889 0.124670987186631 941 5322280 SGTC_3343 9148379 18.9835 µM -1.15216525454648 0.130434320364251 no 2890 0.124626586242846 928 1955036 SGTC_1790 st045711 43.5 µM -1.15234266858389 0.130398328461843 no 2891 0.124590144931195 900 585119 SGTC_590 k048-0076 22.4 µM -1.15388181390298 0.13008637108152 no 2892 0.124274313024054 977 6832814 SGTC_182 3448-4371 550.524 µM -1.15680186403905 0.129495949258611 no 2893 0.123676660053734 940 3491403 SGTC_658 3253-0951 102 µM -1.15803791570743 0.129246584965684 no 2894 0.123424281911372 975 1184878 SGTC_196 k015-0023 18.111 µM -1.15879449249385 0.129094115507616 no 2895 0.123269981495548 949 5211998 SGTC_2074 5212007 75.395 µM -1.1609102204924 0.128668404680163 no 2896 0.122839206015518 941 758611 SGTC_328 k915-0120 63.5 µM -1.16130399421614 0.128589280146471 no 2897 0.12275914788112 958 6624543 SGTC_2523 spermine 47.74 µM -1.16141921813462 0.128566133544569 no 2898 0.122735728628884 944 1103 A DNA binding polyamine. SGTC_3277 9138724 49.47 µM -1.16285550986578 0.128277848671716 no 2899 0.122444065416341 970 15943418 SGTC_2563 tomatine 8.54 µM -1.16295762549809 0.128257369666871 no 2900 0.122423347653395 976 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1558 st069300 45.6 µM -1.16656136024683 0.127536104182043 no 2901 0.121693777639481 954 24208000 SGTC_339 3091-4833 71.4 µM -1.16845752843359 0.127157732177822 no 2902 0.121311130692403 965 3240077 SGTC_3039 9090270 49.47 µM -1.16960722962177 0.126928695103561 no 2903 0.121079533299994 949 17173750 SGTC_35 0133-0054 64.071 µM -1.17115831829517 0.126620151130201 no 2904 0.120767573005529 969 99677 SGTC_2184 6075246 200 µM -1.17332287091175 0.126190450077342 no 2905 0.120333177027678 953 2267320 SGTC_1730 st033808 45.1 µM -1.17384036300494 0.126087869690679 no 2906 0.120229486702839 962 1045166 SGTC_426 0988-0037 14.6 µM -1.1740089675536 0.126054460445011 no 2907 0.120195716868408 973 5383008 SGTC_2064 5220758 200 µM -1.17745730155602 0.125372521502179 no 2908 0.11950651518312 960 788518 SGTC_456 gingerol 170 µM -1.18069929058207 0.124733741734521 no 2909 0.118861101719098 971 442793 A herb. SGTC_1400 3771-8998 51.5 µM -1.18315527711614 0.124251347264403 no 2910 0.118373806898612 974 670767 SGTC_1561 5-methoxyflavone 52.9 µM -1.18347432546814 0.124188777039947 no 2911 0.11831060798104 940 94525 SGTC_2048 5246248 200 µM -1.1838693494038 0.124111337395247 no 2912 0.118232392443335 951 677046 SGTC_1972 st070201 17.4 µM -1.1856176282316 0.123769014231425 no 2913 0.117886668706727 975 2829099 SGTC_2977 9011197 71.43 µM -1.18833377990439 0.123238488130532 no 2914 0.117350967121117 939 2704722 SGTC_2182 6325192 200 µM -1.18887805698196 0.123132370399587 no 2915 0.117243828029904 942 736248 SGTC_1948 st076329 66.6 µM -1.18914093415739 0.123081140165098 no 2916 0.117192106373114 971 24208413 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.18935828345854 0.123038793814049 no 2917 0.117149354633226 965 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1916 st067606 49.2 µM -1.19015591907099 0.122883477301036 no 2918 0.116992557572093 930 19590279 SGTC_2650 prasterone 100 µM -1.19130653475689 0.122659670389163 no 2919 0.116766634733322 958 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_3292 9120825 59.784 µM -1.19189490118775 0.122545337456257 no 2920 0.116651228857145 957 24824900 SGTC_2220 6782180 200 µM -1.19227897769992 0.122470743033936 no 2921 0.116575937329263 958 833803 SGTC_2406 ethylparaben 405.7 µM -1.19352310889127 0.122229329641163 no 2922 0.116332283673934 995 8434 A possible steroid mimic. SGTC_1611 st001856 99.4 µM -1.19433407354564 0.122072148607075 no 2923 0.116173657042887 987 647478 SGTC_2432 5630864 12.22 µM -1.19442726676029 0.122054095010675 no 2924 0.11615543806505 971 5714970 SGTC_1398 3558-0053 112 µM -1.19487279222604 0.121967812737083 no 2925 0.116068367269359 968 4532369 SGTC_1552 6-methylflavone 10.6 µM -1.19607300181565 0.121735588449477 no 2926 0.115834036128395 975 689013 SGTC_1273 0849-0096 14.1 µM -1.19744488377482 0.121470528608185 no 2927 0.115566599058454 987 5286025 SGTC_2708 st078559 56 µM -1.19890235584723 0.121189376747336 no 2928 0.115282957804178 938 17250902 SGTC_817 1391-0715 46 µM -1.19928439513097 0.121115755699558 no 2929 0.115208690377847 972 1353946 SGTC_2102 5377816 72.7585 µM -1.19968622737087 0.121038354395107 no 2930 0.11513061196211 968 1379702 SGTC_493 zm226600 134 µM -1.20019424400435 0.120940549570901 no 2931 0.115031955140764 971 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2829 7992743 58.44 µM -1.20025080817011 0.120929663116574 no 2932 0.115020974101506 976 16462845 SGTC_169 k015-0017 16.025 µM -1.20112285773062 0.120761913944666 no 2933 0.114851773787479 990 1840002 SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.20152574362388 0.120684469361313 no 2934 0.114773663262497 937 6708630 An antioxidant. SGTC_2545 solidagenone 89.61 µM -1.20555573699957 0.119911729138634 no 2935 0.113994417387796 926 6708572 An anti ulcer agent SGTC_1284 0929-0043 16 µM -1.20598661629347 0.119829316082668 no 2936 0.113911325473569 979 1239883 SGTC_57 miconazole 162.5 nM -1.20636189896629 0.119757569379569 no 2937 0.113838990131446 936 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_83 0170-0301 39.027 µM -1.20783722674896 0.119475809214506 no 2938 0.113554939557224 997 3089716 SGTC_2390 9097792 176.6 µM -1.20995931021375 0.119071351431949 no 2939 0.113147253384844 964 4497149 SGTC_3127 9126946 49.47 µM -1.2110132358474 0.118870838501436 no 2940 0.112945166010522 954 27243249 SGTC_3 0833-0587 95.581 µM -1.21315916306211 0.118463305978114 no 2941 0.112534486929285 974 5382644 SGTC_1084 voriconazole 435 nM -1.213754639032 0.118350394517382 no 2942 0.112420716381251 975 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_598 3937-0236 20.2 µM -1.21397505756693 0.118308619050516 no 2943 0.112378624465249 978 1379313 SGTC_2608 thymoquinone 42.66 µM -1.21611898702004 0.117902828352627 no 2944 0.111969799321944 981 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2686 alizarin 95.37 µM -1.21615902059177 0.117895260404409 no 2945 0.111962175461785 945 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_31 0508-1974 57.237 µM -1.21855316557752 0.117443295849447 no 2946 0.111506917093747 946 6810525 SGTC_1115 galangin 695.678 nM -1.22504995345379 0.116223023901991 no 2947 0.110278199904072 989 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2238 6671620 73.2395 µM -1.22507059402726 0.116219161437704 no 2948 0.110274311752563 964 729941 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.22581096485025 0.116080676298068 no 2949 0.110134909995999 963 3256 An antibiotic and ribosome inhibitor. SGTC_1410 3909-8106 77.9 µM -1.2283228956869 0.115611696759803 no 2950 0.109662889707818 981 1039210 SGTC_2469 5655019 90.81 µM -1.22838190076302 0.11560069666781 no 2951 0.109651819471038 984 2788239 SGTC_3234 9132280 49.47 µM -1.23081917315922 0.115146974750146 no 2952 0.109195251458514 969 17612295 SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.23158297761003 0.115005046053073 no 2953 0.109052451431754 986 1273210 SGTC_702 1488-0190 94 µM -1.23256175587031 0.114823353253286 no 2954 0.108869656405539 966 949357 SGTC_559 1550-0661 158 µM -1.23294727292757 0.114751844944882 no 2955 0.108797718374906 982 5830875 SGTC_305 1682-2595 20.8 µM -1.23645385985929 0.114102874037916 no 2956 0.108144953202949 969 226033 SGTC_2376 9072922 81.32 µM -1.23753872028891 0.113902627336769 no 2957 0.107943574303913 992 17087968 SGTC_131 0141-0277 33.849 µM -1.23812898656047 0.113793779517551 no 2958 0.107834118714266 997 1547771 SGTC_2884 9058502 51.95 µM -1.23935777911572 0.113567422359261 no 2959 0.107606514954799 982 6471554 SGTC_2843 9000894 45.46 µM -1.24104443621395 0.113257244522316 no 2960 0.107294666939878 942 2242070 SGTC_1969 st069479 40.1 µM -1.24322845703207 0.112856499624682 no 2961 0.106891829555578 975 3895485 SGTC_1908 st060353 56.5 µM -1.25004131877302 0.111612917863685 no 2962 0.105642227025643 989 4227716 SGTC_2076 5212012 200 µM -1.25352951700896 0.110980010135437 no 2963 0.105006531951546 981 604802 SGTC_79 0052-0007 94.094 µM -1.25444256114899 0.110814770366161 no 2964 0.104840595445889 945 2801472 SGTC_1941 st076221 61.8 µM -1.25462450143097 0.11078186447708 no 2965 0.104807552345251 935 2828568 SGTC_1073 triclabendazole 3.09 µM -1.25630988381215 0.11047737743107 no 2966 0.104501819902733 985 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2754 granisetron 64.02 µM -1.25641381187856 0.110458621083478 no 2967 0.104482988272572 1004 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1075 aripiprazole 15.2 µM -1.25710415422912 0.110334089960386 no 2968 0.104357961544087 1005 60795 An atypical antipschotic. YIL048W NEO1 SGTC_319 1348-1596 45.5 µM -1.25724171308672 0.1103092876989 no 2969 0.104333061453152 987 5380505 SGTC_265 mycophenolic acid 32.932 µM -1.26054168000635 0.109715492094969 no 2970 0.103737011007774 1011 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2186 6124449 200 µM -1.26121463065863 0.109594683650316 no 2971 0.103615764391962 975 3834182 YLR033W RSC58 SGTC_2000 st075254 36.4 µM -1.2622475497056 0.109409439360763 no 2972 0.103429861784595 968 17234175 SGTC_1010 4112-3296 15.2 µM -1.26542198653295 0.108841541980584 no 2973 0.102860048876575 971 704384 SGTC_1792 st045773 43.6 µM -1.26744557337424 0.108480636170753 no 2974 0.102498006527965 938 2919270 SGTC_100 0086-0128 49.5915 µM -1.26755138086824 0.108461789165419 no 2975 0.102479101902589 990 93297 SGTC_2369 9071472 200 µM -1.26863321813913 0.108269221610268 no 2976 0.102285955491512 982 17296037 SGTC_1169 aniline yellow 25.8 µM -1.26875783254975 0.10824705599926 no 2977 0.102263724406086 979 6051 A DNA damaging agent. SGTC_1415 3966-0071 78.1 µM -1.26982674418462 0.10805705901735 no 2978 0.10207317599564 984 2893185 SGTC_844 0330-0132 15.3 µM -1.27137422271849 0.107782423286481 no 2979 0.101797774265984 979 2828079 SGTC_3014 9081533 49.47 µM -1.27268773731871 0.107549704656474 no 2980 0.101564435383368 1000 21367265 SGTC_779 1360-0071 233 µM -1.27462146146126 0.107207761227991 no 2981 0.101221628737139 979 7566 SGTC_2744 captopril 92.04 µM -1.27541055390698 0.107068450241941 no 2982 0.101081982540747 995 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1043 0916-0009 19.3 µM -1.27827321376457 0.106564155631554 no 2983 0.100576554550589 995 3101130 SGTC_2934 9036370 36.88 µM -1.2827121536458 0.105785573334615 no 2984 0.0997964701678115 958 6462800 SGTC_2380 9035439 200 µM -1.28470639855545 0.105437128114106 no 2985 0.0994474507400268 980 6462575 SGTC_2648 atorvastatin 78.68 µM -1.28565576107067 0.105271542357608 no 2986 0.0992816134694104 983 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_697 0508-1955 564 µM -1.28602378941897 0.105207402281597 no 2987 0.0992173796743312 994 6243113 SGTC_72 0744-0168 198.391 µM -1.28682430270974 0.105067986276767 no 2988 0.0990777671075047 1010 677577 SGTC_2960 9079389 5.97 µM -1.28690990991356 0.105053084992947 no 2989 0.0990628453940848 990 16457355 SGTC_2046 4110841 106 µM -1.28755545914974 0.104940766224889 no 2990 0.098950376243215 973 44119630 YMR134W ERG29 SGTC_1356 1502-0781 85.8 µM -1.28944457447493 0.104612579557558 no 2991 0.0986217867157721 978 567702 SGTC_1797 st048695 56.8 µM -1.29020499412522 0.10448068568485 no 2992 0.0984897463142339 975 592262 YIL048W NEO1 SGTC_1877 wortmannin 25 µM -1.29509177327559 0.103635953974656 no 2993 0.0976442862639121 991 312145 A covalent inhibitor of PI 3-kinase. SGTC_1688 st021091 57.6 µM -1.29840827386981 0.103065491418944 no 2994 0.097073538746633 1028 3656366 SGTC_1649 st011737 51.3 µM -1.29913922507379 0.102940069734917 no 2995 0.0969480769176199 930 1761035 SGTC_3177 9107506 49.47 µM -1.29983253036752 0.102821210094918 no 2996 0.096829186744873 985 8897194 SGTC_2255 7941087 197.44 µM -1.3010931530753 0.102605345638418 no 2997 0.0966132855651743 1016 935561 SGTC_2742 clothiapine 36.27 µM -1.30209727622415 0.102433639084361 no 2998 0.0964415670845211 993 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_699 0375-0592 111 µM -1.30234043136648 0.102392090634731 no 2999 0.096400018054244 967 762578 SGTC_219 mitoxanthrone 164.414 µM -1.30358322165601 0.102179923726936 no 3000 0.0961878622108121 1011 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2890 9046729 58.44 µM -1.30486592018613 0.1019612793257 no 3001 0.0959692538081497 987 903329 SGTC_3214 9129694 49.47 µM -1.30552519554059 0.101849034064317 no 3002 0.0958570367470268 1012 17158655 SGTC_1210 3013-0140 750 nM -1.30773755894629 0.10147302437093 no 3003 0.0954811697045276 994 905973 SGTC_2379 9035213 200 µM -1.30799906054019 0.101428646889724 no 3004 0.0954368139661124 982 646551 SGTC_1750 st081859 2.357 µM -1.30855327468943 0.101334642081086 no 3005 0.0953428586439096 969 5291695 SGTC_2107 5363541 170.161 µM -1.31039681916719 0.101022400133649 no 3006 0.0950308145629582 987 244052 SGTC_2738 aclarubicin 5.55 µM -1.3143676822329 0.100352236607927 no 3007 0.0943612503299084 1003 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2278 7948257 134.34 µM -1.318655196687 0.0996322809512518 no 3008 0.0936422057877435 988 1247028 SGTC_2629 bisabolol 100 µM -1.3190157623411 0.0995719075715231 no 3009 0.093581921468783 1009 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1828 st055811 49 µM -1.32064164117993 0.0993000012846581 no 3010 0.0933104406684188 991 5877589 SGTC_398 bronopol 33.3 µM -1.32085596593562 0.0992641988991075 no 3011 0.0932746972846773 986 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_135 0933-0004 26.348 µM -1.32120383212924 0.0992061088615843 no 3012 0.0932167044549089 970 21230617 YGL099W LSG1 SGTC_939 1165-0479 45.3 µM -1.32334324482665 0.0988493956758172 no 3013 0.0928606283149982 973 1377347 SGTC_2745 rifampicin 24.3 µM -1.3236848238552 0.0987925297745789 no 3014 0.0928038703590716 977 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2525 harmine 47.85 µM -1.32422257091147 0.0987030544360659 no 3015 0.09271456843146 972 5280953 A monoamine oxidase inhibitor SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.32607413223973 0.0983954282012474 no 3016 0.0924075717244119 983 17037758 SGTC_1796 st049173 110.4 µM -1.32656688234175 0.0983136790251289 no 3017 0.092325998540166 993 94134 SGTC_1178 0988-0033 191 µM -1.32659321494885 0.0983093117428398 no 3018 0.0923216407628438 985 5392207 SGTC_3042 9091578 49.47 µM -1.33104347322975 0.0975732727846089 no 3019 0.0915873534275193 974 25236497 SGTC_10 0279-0212 42.575 µM -1.33188170867825 0.0974350884609024 no 3020 0.0914495312618332 1016 39851 YBR002C RER2 SGTC_2740 felodipine 17.08 µM -1.33244345069204 0.0973425648456164 no 3021 0.0913572560447092 999 3333 L-type calcium channel blocker SGTC_780 0109-0199 192 µM -1.3345742280695 0.0969921939080118 no 3022 0.091007868810841 979 610414 SGTC_534 k292-0788 63.4 µM -1.3353251696135 0.0968689349329028 no 3023 0.0908849721376295 998 4146317 SGTC_2219 9098279 200 µM -1.33671047220583 0.0966418542669816 no 3024 0.0906585811374594 988 902349 SGTC_1691 st019933 84.6 µM -1.34096853906776 0.0959463145746724 no 3025 0.0899653336899589 1017 6176082 SGTC_798 1287-0182 476 µM -1.3481066208793 0.0947886050729375 no 3026 0.0888120461248927 1025 1649755 SGTC_1855 st056195 39.6 µM -1.34865557458489 0.0946999996244623 no 3027 0.0887238105877177 966 4028379 SGTC_1014 4130-3005 69.3 µM -1.34917459061949 0.0946162825071285 no 3028 0.0886404471093797 1016 743608 SGTC_1997 st073024 93.8 µM -1.35181715046755 0.0941908843214446 no 3029 0.0882169081413545 1008 686268 SGTC_2384 9036245 200 µM -1.3522998217389 0.0941133367248882 no 3030 0.0881397107068839 965 6462766 SGTC_2355 9061122 103.12 µM -1.35413518041238 0.0938188918805133 no 3031 0.0878466270798996 1027 5302957 SGTC_2215 7188065 200 µM -1.35532630533353 0.0936281650373063 no 3032 0.0876568087844566 1006 940217 SGTC_1560 lithocholic acid 53.1 µM -1.35629094857111 0.0934739131273727 no 3033 0.0875033071348127 972 9903 A bile acid which acts as a detergent. SGTC_1644 st010134 20.9 µM -1.3599542358761 0.0928898425161355 no 3034 0.086922203191335 1004 3818134 SGTC_1799 st045822 46.1415 µM -1.36232724910782 0.092512934595115 no 3035 0.0865473158945858 963 3674992 SGTC_3344 9148862 3.898 µM -1.37581012033138 0.0903928936107337 no 3036 0.0844402136932011 1019 4905352 SGTC_1701 st028638 40.4 µM -1.37658571368269 0.0902720461299996 no 3037 0.0843201851605247 1008 3490878 SGTC_3107 9121808 49.47 µM -1.37674505910372 0.0902472329172835 no 3038 0.0842955411970791 945 662681 SGTC_2096 5468907 200 µM -1.37701311428051 0.0902055028893208 no 3039 0.0842540966506673 1012 759785 SGTC_1791 st048313 56.1 µM -1.37846342185964 0.089979971880987 no 3040 0.0840301268746366 975 1204976 SGTC_959 1222-0044 107 µM -1.37980638441277 0.0897715075164565 no 3041 0.0838231331851574 987 6083612 SGTC_2678 equilin 100 µM -1.38001916714046 0.0897385108172779 no 3042 0.0837903717056033 963 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1346 1488-2224 62.4 µM -1.38106517719425 0.0895764347669974 no 3043 0.0836294607051761 982 3722427 SGTC_2866 9034245 58.44 µM -1.38155762950401 0.0895002061977036 no 3044 0.0835537856561756 1000 6462273 SGTC_1096 rimcazole 32.2 µM -1.39214673090994 0.0878727308972493 no 3045 0.0819389848668659 1008 18528119 A dopamine reuptake inhibitor. SGTC_1988 st071872 53.4 µM -1.39276781216636 0.0877779645825153 no 3046 0.0818450074247078 1012 16414116 SGTC_2522 biochanin a 4.94 µM -1.39410524380926 0.0875741543981649 no 3047 0.0816429129615355 1006 5280373 A possible chelator. SGTC_3021 9087658 49.47 µM -1.39510045112864 0.0874227248149962 no 3048 0.0814927750876229 995 25237042 SGTC_1939 st074455 53.6 µM -1.39672420311964 0.0871760763187186 no 3049 0.0812482615312525 1014 1644229 SGTC_1370 2001-0092 44.6 µM -1.39945796295328 0.0867619917039057 no 3050 0.0808378478642576 1008 790957 SGTC_1926 methyl fluorone black 53.6 µM -1.40064999296308 0.0865818949063909 no 3051 0.0806593817090861 950 72721 Reacts with homocysteine. SGTC_1815 st051655 58.2 µM -1.40144100653738 0.0864625396575553 no 3052 0.0805411185415833 1000 5984156 SGTC_1559 coumarin 343 70.1 µM -1.40523368751259 0.0858919742878055 no 3053 0.079975899905777 1004 108770 A hepatotoxic, DNA x-linker. SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.40582182398726 0.0858037488442362 no 3054 0.0798885199108462 991 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2032 5185112 25.99 µM -1.40990815891153 0.0851926361021268 no 3055 0.079283401612261 988 5718189 SGTC_1970 st070122 35.8 µM -1.41109226624068 0.0850161633576185 no 3056 0.0791087050462032 1017 102928 SGTC_1971 st069429 63.5 µM -1.41611923784012 0.0842700214965478 no 3057 0.0783702982250521 998 1246522 YGL099W LSG1 SGTC_1891 st059073 26.2 µM -1.41980674727334 0.0837258255024628 no 3058 0.0778319750515509 1017 688754 SGTC_2825 7998094 58.44 µM -1.41999534787464 0.0836980632971887 no 3059 0.0778045177113637 1010 2987815 SGTC_2828 7998861 71.43 µM -1.42259649588914 0.0833158767176147 no 3060 0.0774265801969442 983 2988188 SGTC_1058 3448-5425 97.3 µM -1.42462791981716 0.0830183131939265 no 3061 0.0771323924811558 1015 7279705 SGTC_606 k015-0008 38.6 µM -1.42504993082816 0.0829565973065302 no 3062 0.0770713841824672 1036 1970475 SGTC_2288 7946289 167.31 µM -1.42537773998999 0.0829086815408237 no 3063 0.0770240195476902 1021 1246052 SGTC_2741 miltefosine 3.04 µM -1.43467916922719 0.0815577558741666 no 3064 0.0756892714101255 996 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1698 5-fluorocytosine 1.055 µM -1.43554980375249 0.0814321607269587 no 3065 0.0755652434542471 999 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1521 st012942 49.4 µM -1.43831444918262 0.0810343082235309 no 3066 0.0751724269829836 1002 24207259 SGTC_2518 prenyletin 46.28 µM -1.44276034224844 0.0803975911017578 no 3067 0.0745439971369688 1000 3873459 A coumarin with calcium channel inhibitory activity. SGTC_112 phenothiazine 287.218 µM -1.44353262815694 0.080287374826373 no 3068 0.0744352440088261 1014 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2894 9048625 32.47 µM -1.44362187016305 0.0802746460754506 no 3069 0.0744226847810133 1013 4092861 SGTC_3084 9116877 49.47 µM -1.44381516373201 0.0802470814884198 no 3070 0.0743954876903602 1006 27241325 SGTC_1490 4089-0339 670 nM -1.44593673948618 0.0799450046303067 no 3071 0.0740974729990915 1015 742542 SGTC_2158 5657123 3.6195 µM -1.44606422148493 0.0799268807516641 no 3072 0.0740795948733288 1029 2858827 SGTC_1461 k072-0203 53.8 µM -1.44632783036473 0.0798894138226915 no 3073 0.0740426367124423 997 5418714 SGTC_2024 5144227 134 µM -1.44699154354458 0.0797951385890415 no 3074 0.0739496460150592 1007 3475211 SGTC_2073 5212005 126 µM -1.44792623948707 0.079662515112611 no 3075 0.0738188401645674 1002 691789 SGTC_1979 st071809 45.3 µM -1.4485107869604 0.0795796588007763 no 3076 0.0737371256985011 1019 4976333 SGTC_784 4579-0127 173 µM -1.45026070091313 0.079332008136484 no 3077 0.0734929168035887 1021 1948547 SGTC_3180 9109287 49.47 µM -1.4510554832398 0.0792197220920338 no 3078 0.0733822055691472 998 18891271 SGTC_1903 st060211 78.3 µM -1.453655899237 0.0788531788062725 no 3079 0.0730208653454013 1001 688960 SGTC_41 0478-0632 82.643 µM -1.45554292923836 0.0785879968209804 no 3080 0.0727595072843384 993 3750424 SGTC_3176 9106582 49.47 µM -1.45653746962199 0.0784485075751434 no 3081 0.0726220496595558 1003 17018027 SGTC_588 3970-1144 52.9 µM -1.45979642877129 0.0779927374975015 no 3082 0.0721730151769997 1008 1888707 SGTC_1351 1496-0003 46.5 µM -1.46047262426371 0.0778984227748286 no 3083 0.0720801129799824 1028 3891978 SGTC_774 k060-0086 136 µM -1.46147465537403 0.0777588201854494 no 3084 0.0719426129884508 1026 5911235 SGTC_1322 1348-1070 12 µM -1.46404261988084 0.0774019193659794 no 3085 0.0715911518284301 1011 6758089 SGTC_1263 0774-1208 64.8 µM -1.47298922051671 0.0761682175610203 no 3086 0.0703769712079122 1022 906585 SGTC_2852 9023854 51.95 µM -1.47365367676195 0.0760771921260802 no 3087 0.070287430579352 1029 19798528 SGTC_1681 tripelennamine 100 µM -1.47371106598308 0.0760693341275182 no 3088 0.0702797010490209 997 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1340 1486-1359 257 µM -1.47434995770735 0.075981895831106 no 3089 0.0701936953547721 1001 4309068 SGTC_2687 chenodiol 100 µM -1.47467589978996 0.0759373171038851 no 3090 0.0701498492015848 996 5702181 A cholesterol synthesis inhibitor. SGTC_3096 9117468 49.47 µM -1.47635193060807 0.0757084027234123 no 3091 0.0699247199662974 1001 41316311 SGTC_2488 5268135 45.7 µM -1.48255520171698 0.0748657238715314 no 3092 0.0690963134664719 1009 1270356 YLR208W SEC13 SGTC_2576 guaiol 23.12 µM -1.48519795807706 0.0745089017222856 no 3093 0.068745696385125 988 227829 SGTC_478 N-arachidonylglycine 10 µM -1.48976971251638 0.0738946957996497 no 3094 0.0681423986951391 1037 5283389 SGTC_2010 4012422 159 µM -1.49077825456746 0.0737597226049988 no 3095 0.068009861370823 1006 952393 SGTC_2415 st077333 57.7 µM -1.49775475891401 0.0728312120010796 no 3096 0.0670984894853514 1007 2766255 SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.5049373510301 0.0718846491765015 no 3097 0.0661700921633336 1015 77254 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.50597009889754 0.0717493270982544 no 3098 0.0660374248719653 996 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_803 4488-1585 147 µM -1.50759342675184 0.0715370157533605 no 3099 0.0658293080599854 1005 747204 SGTC_2025 5147754 141 µM -1.51437727271488 0.0706549855704736 no 3100 0.064965090074623 971 315777 YLR208W SEC13 SGTC_808 0711-0032 135 µM -1.51864523054243 0.0701043672546195 no 3101 0.0644259097891109 1015 4252555 SGTC_2077 5212015 200 µM -1.52046443847053 0.0698706731663103 no 3102 0.0641971449252271 1013 780900 SGTC_33 0986-0033 35.816 µM -1.52547492450152 0.069230129197129 no 3103 0.0635703416579105 989 2848082 SGTC_3105 9121040 49.47 µM -1.52861251067367 0.0688313275713883 no 3104 0.063180266355464 991 41448907 SGTC_2226 7298446 200 µM -1.52898349832923 0.0687842906659003 no 3105 0.0631342674043746 1040 3283010 SGTC_50 0929-0078 56.389 µM -1.53027026126305 0.0686213361861917 no 3106 0.0629749230910465 984 1377751 SGTC_2354 9060492 162 µM -1.53054724778646 0.068586297842026 no 3107 0.0629406639011735 1029 6471895 SGTC_3064 1327-0027 10 µM -1.53055696256605 0.0685850691887536 no 3108 0.0629394625883387 1007 16000455 YPR107C YTH1 SGTC_2941 9056145 11.23 µM -1.5305963748809 0.0685800847856142 no 3109 0.062934589112902 1013 2119517 SGTC_3246 9135460 32.98 µM -1.53117095029594 0.0685074510112492 no 3110 0.062863574160612 1025 41446951 SGTC_2045 5106652 78.05 µM -1.533850173433 0.0681695457723764 no 3111 0.0625332581790262 1003 673349 SGTC_3100 9120536 49.47 µM -1.53615227941686 0.0678802316266281 no 3112 0.0622505183870091 1014 16421196 SGTC_2946 9065502 71.43 µM -1.53672915078802 0.0678078828628319 no 3113 0.0621798247361514 974 16489101 SGTC_1654 st012436 41.8 µM -1.5393163331329 0.0674841417297194 no 3114 0.0618635442181449 1046 4323132 SGTC_2753 fluvastatin 17.09 µM -1.5431866067591 0.0670020755686835 no 3115 0.061392752979166 1033 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.54684447420989 0.0665489182219918 no 3116 0.0609503764821159 1042 368090 SGTC_1885 st057546 99.9 µM -1.55206320299762 0.0659065040430418 no 3117 0.0603235507383317 1001 702008 SGTC_2763 lisinopril 49.32 µM -1.55469680751529 0.0655841428375818 no 3118 0.0600091476508774 1007 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3024 9090631 49.47 µM -1.55477109623191 0.0655750674341688 no 3119 0.0600002976132185 1010 25236383 SGTC_1434 4073-0095 163 µM -1.55623920850137 0.0653959167399508 no 3120 0.0598256105542161 1024 24133745 SGTC_1497 4476-2978 41.3 µM -1.56059867550355 0.0648661770114528 no 3121 0.0593092357428641 1012 1528379 SGTC_2891 9063876 19.48 µM -1.56066797119197 0.0648577835397738 no 3122 0.0593010560388141 1022 6472478 SGTC_851 0394-0702 453 µM -1.56084053349847 0.0648368855166005 no 3123 0.0592806905260635 1037 762646 SGTC_3354 9151612 71.43 µM -1.56165849208463 0.0647378983982766 no 3124 0.0591842310297009 1013 27261949 SGTC_415 dibenzyl ketone 100 µM -1.56278807357234 0.0646013925129772 no 3125 0.0590512251641775 1027 7593 SGTC_548 1436-0017 110 µM -1.56505716147884 0.064327857095919 no 3126 0.0587847534695074 1032 9677137 SGTC_477 mead ethanolamide 10 µM -1.56960923502422 0.0637818257410161 no 3127 0.0582530243533157 1043 16061185 SGTC_1794 st048918 76.9 µM -1.56981580978341 0.063757132420627 no 3128 0.0582289842082322 971 672303 SGTC_1454 4239-0054 42.6 µM -1.57089713991331 0.0636279948274428 no 3129 0.0581032715297857 1023 1340767 SGTC_3048 9093155 49.47 µM -1.57478055540516 0.0631658961978995 no 3130 0.0576535530892012 1019 25236002 SGTC_247 mechlorethamine 29.705 µM -1.57641283909453 0.0629724479548613 no 3131 0.0574653456969885 1020 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_865 0488-0499 301 µM -1.57671842002047 0.0629362837195646 no 3132 0.0574301650362553 1016 9634651 SGTC_3065 9113888 49.47 µM -1.57882474701808 0.0626874486045465 no 3133 0.0571881303355073 1028 16648368 SGTC_2820 7989630 71.43 µM -1.57950272837155 0.0626075172671099 no 3134 0.0571103955983218 1013 2984098 SGTC_164 4100-3994 89.624 µM -1.5806074854888 0.0624774409681493 no 3135 0.0569839066095833 1043 4615967 SGTC_2914 7968218 45.32 µM -1.58398325396546 0.0620812766587013 no 3136 0.0565987649797197 1012 2977111 SGTC_2994 9053520 71.4286 µM -1.58691224607944 0.0617391343489482 no 3137 0.0562662604848992 1029 4647384 SGTC_1031 k035-0009 16 µM -1.58923191945556 0.0614692139854496 no 3138 0.0560040213000465 1037 5180959 SGTC_2324 6149169 200 µM -1.58959048257048 0.0614275734648554 no 3139 0.0559635718847132 1029 2888231 SGTC_967 1306-0166 352 µM -1.59103554831653 0.0612599789217684 no 3140 0.0558007879195224 1045 4437607 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.59427593531501 0.0608854671391206 no 3141 0.0554371225869503 1025 756377 SGTC_2605 digitonin 300 nM -1.60016422026546 0.0602095059599599 no 3142 0.0547810786435904 1030 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2667 digitoxin 100 µM -1.60318227344781 0.0598653252474275 no 3143 0.0544472089670176 1009 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.60555937332906 0.0595953257404816 no 3144 0.0541853789628102 1012 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2748 diazoxide 86.69 µM -1.60690466147133 0.0594429465049761 no 3145 0.0540376418484042 1022 3019 A potassium channel activatior. SGTC_1693 xanthone 101.9 µM -1.60994860469285 0.0590992899806204 no 3146 0.0537045384229488 1048 7020 An insecticide. SGTC_2103 5378138 10 µM -1.61240126176143 0.058823524070934 no 3147 0.0534373252426991 1032 244142 SGTC_3040 9091894 49.47 µM -1.61381884125382 0.058664598794283 no 3148 0.053283363261728 1024 25236966 SGTC_2910 7948405 25.97 µM -1.61662090833692 0.0583514499262852 no 3149 0.0529800679251558 1003 2971328 SGTC_763 3453-1109 128 µM -1.61805364177283 0.058191840886559 no 3150 0.0528255189454774 1038 1560353 SGTC_882 0843-0131 351 µM -1.62306955384525 0.0576357604988728 no 3151 0.0522872685999659 1029 5425421 SGTC_2909 7941780 10.49 µM -1.62383362018599 0.0575514216055064 no 3152 0.0522056613098429 1020 1243215 SGTC_1176 0848-0131 83.3 µM -1.62404601671243 0.0575279941800382 no 3153 0.0521829939468058 1044 6769040 SGTC_3136 9095672 49.47 µM -1.62414252085568 0.0575173522115187 no 3154 0.0521726974233143 1018 17217380 SGTC_2861 9024595 19.48 µM -1.62532498875706 0.0573870815768575 no 3155 0.0520466648173959 1034 16482810 SGTC_3060 1327-0027 12.5 µM -1.63165134376557 0.0566940561137625 no 3156 0.0513764777429095 1003 16000455 YPR107C YTH1 SGTC_1615 st002656 86.5 µM -1.63326369798379 0.0565184880199177 no 3157 0.0512067741225844 1050 1584458 SGTC_2743 auranofin 4.32 µM -1.63531135690235 0.0562961377895676 no 3158 0.0509918970033812 1032 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_3270 9137563 49.47 µM -1.63600839517929 0.0562206056437534 no 3159 0.0509189151948695 1015 17015724 SGTC_1435 4092-0789 56.7 µM -1.63679978492313 0.0561349463077627 no 3160 0.0508361553559139 1031 2248285 SGTC_1413 3910-0535 34.4 µM -1.63831427336098 0.0559713063604718 no 3161 0.0506780758494713 1042 2876951 SGTC_3271 9137798 49.47 µM -1.64084716154363 0.0556984698132455 no 3162 0.0504145727953908 990 6498326 SGTC_2311 7694451 200 µM -1.64249986389369 0.0555210113305564 no 3163 0.0502432271707046 1038 2163142 SGTC_3262 9137218 49.47 µM -1.64673131582677 0.0550686943536497 no 3164 0.0498066422178455 1023 17650664 SGTC_2669 eugenol 100 µM -1.64712515192115 0.0550267441503879 no 3165 0.0497661621381902 1033 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_161 4065-0411 162.148 µM -1.6472927315627 0.0550089017447162 no 3166 0.0497489455813098 1041 1906281 YLR208W SEC13 SGTC_2246 7293507 91.5585 µM -1.64855452001437 0.0548747043671669 no 3167 0.0496194663047178 1038 887656 SGTC_2670 beta-carotene 100 µM -1.65555950753215 0.0541343892935511 no 3168 0.0489055280426263 1017 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2634 4'-methoxyflavone 100 µM -1.66057522432209 0.0536091811262837 no 3169 0.0483993941598571 1036 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_3230 9131665 49.47 µM -1.66608456825513 0.0530369446950975 no 3170 0.0478482858520126 1019 15943720 SGTC_2983 9022671 12.99 µM -1.67165688272439 0.0524631056904895 no 3171 0.0472960005314175 1031 6405161 SGTC_1106 tegaserod maleate 11.7 µM -1.67623642267095 0.0519952021336317 no 3172 0.0468459462651432 1023 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.6777739174251 0.0518388578010318 no 3173 0.0466956214987582 1051 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1590 st077108 57.8 µM -1.67791287659388 0.0518247457895998 no 3174 0.0466820542002471 1040 5489485 SGTC_1345 1488-0192 31.4 µM -1.67804505573309 0.0518113251582522 no 3175 0.0466691518061837 1042 658348 SGTC_39 0986-0283 58.349 µM -1.67852890512973 0.0517622217200402 no 3176 0.0466219462507987 1025 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_567 1080-0542 68.4 µM -1.68250719003425 0.0513598867043409 no 3177 0.0462352659356976 1027 5950415 SGTC_1630 st005209 31.3 µM -1.6825468777956 0.0513558855383354 no 3178 0.0462314213889358 1010 3367314 SGTC_883 0850-0245 24.6 µM -1.68322429096855 0.0512876295987384 no 3179 0.0461658400660502 1030 6823229 YPR165W RHO1 SGTC_1142 3253-1408 9.78 µM -1.68391573780381 0.0512180340788067 no 3180 0.0460989771983217 1059 256655 SGTC_2329 6138490 200 µM -1.684032046058 0.0512063348042246 no 3181 0.046087737843263 1045 720019 SGTC_935 2996-0153 430 µM -1.68404878654601 0.0512046510784522 no 3182 0.0460861203208212 1045 23738523 SGTC_1716 st033144 30.6155 µM -1.686614683917 0.0509470984884789 no 3183 0.0458387333011972 1042 674617 SGTC_3133 9127736 49.47 µM -1.68749921016675 0.0508585533391268 no 3184 0.0457537008343595 1022 27243420 SGTC_2298 7976326 193.81 µM -1.68867147390056 0.0507413931810723 no 3185 0.0456412026046756 1058 2235818 SGTC_2746 daunorubicin 9.88 µM -1.69906904421082 0.0497116068194993 no 3186 0.0446530875992778 1044 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3269 9137823 49.47 µM -1.69979082194331 0.0496407446688032 no 3187 0.0445851392599396 1021 17682936 SGTC_2770 toltrazuril 17.5 µM -1.70646450328261 0.0489893525950433 no 3188 0.0439608149330883 1018 68591 Kills coccidiodes. SGTC_3336 9143619 71.43 µM -1.7120907516362 0.0484455175590594 no 3189 0.0434399727265122 1062 45595730 SGTC_3137 9097352 49.47 µM -1.71573996143461 0.0480953724963315 no 3190 0.043104823613348 1020 44120435 SGTC_1298 1079-1278 263 µM -1.71583024922577 0.0480867350402203 no 3191 0.0430965579957605 1044 2840950 SGTC_185 k048-0037 25.491 µM -1.71627898609449 0.0480438246719737 no 3192 0.0430554962702351 1047 6827589 SGTC_2151 5563267 85.4165 µM -1.71647326435393 0.0480252563628572 no 3193 0.0430377286195497 1060 5310824 SGTC_3168 9103419 49.47 µM -1.72210569457264 0.0474894246915597 no 3194 0.0425251868658389 1053 16649256 SGTC_2262 9014885 67.46 µM -1.72394075876697 0.0473158870562326 no 3195 0.0423592691518855 1067 6457424 SGTC_283 0987-0079 11.7 µM -1.72455836921228 0.0472575955473092 no 3196 0.0423035456981926 1045 411556 SGTC_2447 5741742 33.78 µM -1.7248156646158 0.0472333283993046 no 3197 0.0422803489135992 1041 1776504 SGTC_3202 9113761 49.47 µM -1.72817703253657 0.0469172133617155 no 3198 0.0419782450528928 1040 4798415 SGTC_3261 9137475 49.47 µM -1.7287009073873 0.0468680994794583 no 3199 0.0419313194385506 1032 17027690 SGTC_619 1652-1634 108 µM -1.72928274117393 0.046813600220954 no 3200 0.0418792519909368 1052 5400454 SGTC_1119 parthenolide 318.541 nM -1.72963040056365 0.0467810599004441 no 3201 0.0418481654581245 1055 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1686 st019653 115.5 µM -1.7318480486753 0.0465739186584267 no 3202 0.0416503102980948 1067 97252 SGTC_2461 5755302 26.15 µM -1.73342110360252 0.0464274328966118 no 3203 0.0415104246615144 1056 2788904 SGTC_2295 7971645 200 µM -1.74247944629327 0.0455910860142933 no 3204 0.0407122924584094 1055 2978226 YKL099C UTP11 SGTC_739 1486-1183 203 µM -1.74453914131217 0.0454026170419791 no 3205 0.0405325612046882 1048 4346692 SGTC_1874 staurosporine 7.6 µM -1.74464016672815 0.0453933890244951 no 3206 0.0405237622136012 1035 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2027 5150920 200 µM -1.75017921344827 0.0448897374237127 no 3207 0.0400436972324646 1012 786715 SGTC_2638 epoxomicin 18 µM -1.75109468303247 0.0448069309371543 no 3208 0.0399648009730899 1045 9915668 A protesome inhibitor. SGTC_3226 9131256 49.47 µM -1.7547388848727 0.0444785223900089 no 3209 0.0396519907675399 1030 17178073 SGTC_2421 5690543 90.72 µM -1.75484068004297 0.0444693767199079 no 3210 0.0396432815623249 1046 3397993 SGTC_1805 st050013 60.3 µM -1.75537460969642 0.0444214312363098 no 3211 0.0395976260585616 1041 4037144 SGTC_1251 0490-5699 265 µM -1.7560122935698 0.0443642234855617 no 3212 0.0395431547334585 1055 3883818 SGTC_604 1000-0114 314 µM -1.75609723656371 0.0443566075820084 no 3213 0.0395359034558874 1068 1572745 SGTC_1506 4226-2149 212 µM -1.75814331426583 0.0441734764438365 no 3214 0.0393615637160781 1048 991114 SGTC_2439 5492030 7.2 µM -1.75816332129859 0.0441716887578528 no 3215 0.0393598620738994 1018 5722370 SGTC_113 0099-0221 2.5 µM -1.76310835897144 0.043731620966674 no 3216 0.0389411078425035 1047 89219 SGTC_1424 4048-1941 275 µM -1.76377388430848 0.0436726656769442 no 3217 0.0388850280288251 1049 X1424 SGTC_1739 st037196 92.5 µM -1.7643761658301 0.0436193681108063 no 3218 0.0388343341012584 1036 612214 SGTC_249 wiskostatin 11.211 µM -1.76507941946133 0.0435572016828252 no 3219 0.0387752095042922 1030 2775510 A n-wasp and actin depolymerizer. SGTC_863 0466-0191 129 µM -1.76668554805732 0.0434154907764401 no 3220 0.03864045250048 1057 765160 YPR165W RHO1 SGTC_3086 9117350 49.47 µM -1.76668657016383 0.0434154007132457 no 3221 0.0386403668656029 1037 2679265 SGTC_3190 9110366 49.47 µM -1.77243888821506 0.0429109177780551 no 3222 0.0381608656301123 1049 17123768 SGTC_1882 5615643 20 µM -1.77441167607357 0.0427389975068769 no 3223 0.0379975399611017 1017 2253075 SGTC_1976 st070609 63.5 µM -1.77940825639582 0.0423060563908626 no 3224 0.0375864269187726 1048 682556 SGTC_1000 4048-0884 8.67 µM -1.78355068962686 0.0419498211593734 no 3225 0.0372483521448298 1056 13040088 SGTC_2620 irigenin 100 µM -1.78371542506851 0.0419357048304897 no 3226 0.0372349591897177 1041 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2533 agelasine 13.65 µM -1.78804324497002 0.0415662256721455 no 3227 0.0368845155537982 1033 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_431 k089-0097 107 µM -1.79885629649687 0.0406546009542452 no 3228 0.0360207076738714 996 5499420 SGTC_2435 5706476 10.6 µM -1.80943826195085 0.0397782356219286 no 3229 0.0351914717161182 1037 5725375 SGTC_968 1309-0633 340 µM -1.81150116618136 0.0396091942064219 no 3230 0.0350316543554406 1044 3761976 SGTC_2707 st078556 66.6 µM -1.82061579415747 0.0388692903306583 no 3231 0.0343326401310463 1032 17250899 SGTC_2791 5663188 71.43 µM -1.82245674997191 0.0387212208725617 no 3232 0.0341928552357316 1038 54690634 SGTC_376 3970-0862 59.1 µM -1.82306750811442 0.0386721987698842 no 3233 0.0341465834842644 1038 3135186 SGTC_1498 4478-3555 97.6 µM -1.82405049792194 0.0385934059288206 no 3234 0.034072219139271 1060 3437919 SGTC_284 0988-0104 32.6 µM -1.82723567815424 0.0383389918938699 no 3235 0.0338321708124556 1043 4666532 SGTC_1851 st056236 18.9 µM -1.82903157524439 0.0381961497411057 no 3236 0.0336974391047443 1038 5393171 SGTC_1606 st000094 49.2 µM -1.83742348900171 0.0375344149925699 no 3237 0.0330737009385143 1045 1242210 SGTC_372 0155-0182 15.9 µM -1.84442607409432 0.0369894258787758 no 3238 0.032560535143008 924 771486 SGTC_1610 st001799 48.1 µM -1.84779534516258 0.0367295204685967 no 3239 0.0323159772824385 1055 621897 SGTC_3017 9080681 49.47 µM -1.84952435749286 0.0365967255668257 no 3240 0.0321910669971308 1058 16451914 SGTC_2275 7947463 200 µM -1.84994955333756 0.0365641291081068 no 3241 0.0321604103976473 1028 1225414 SGTC_462 ag-879 158 µM -1.8682864547869 0.0351808269334464 no 3242 0.030861076814443 1059 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_3313 9133968 57.047 µM -1.87605411103499 0.0346079393813093 no 3243 0.0303239250139638 1042 1494643 SGTC_934 2950-0684 338 µM -1.88385474997534 0.0340403530669095 no 3244 0.0297923127021715 1046 1121253 SGTC_326 k292-0812 17.5 µM -1.88711361795362 0.0338055106677455 no 3245 0.0295725227205159 1046 3579357 SGTC_1060 3448-7350 82 µM -1.8922807676995 0.0334358860202411 no 3246 0.0292267910015102 1046 570178 SGTC_2595 hexamethylquercetagetin 100 µM -1.89595165642582 0.0331753210640429 no 3247 0.0289832186867896 1055 386331 SGTC_1059 3448-6867 171 µM -1.89836794071058 0.0330047243514128 no 3248 0.0288238148768035 1059 3934407 SGTC_58 0957-0393 9 µM -1.89870569582636 0.0329809355455143 no 3249 0.0288015911259027 1052 6997992 SGTC_1430 4049-0248 69.1 µM -1.90107832812046 0.0328142240301494 no 3250 0.0286458768846368 1058 22774488 SGTC_2747 doxorubicin 7.63 µM -1.90459091996472 0.0325686900580656 no 3251 0.0284166339085444 1041 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2919 7978188 46.38 µM -1.90746156680456 0.0323691557592225 no 3252 0.0282304216843269 1056 2980291 SGTC_564 3555-0129 330 µM -1.91332496696998 0.0319647334742551 no 3253 0.0278532317019676 1044 563260 SGTC_2932 9016711 44.54 µM -1.91353908677818 0.0319500441042842 no 3254 0.0278395373138713 1065 7117328 SGTC_2819 7996655 46.38 µM -1.91563420554179 0.0318066055541363 no 3255 0.0277058362473125 1050 6456960 SGTC_110 0850-0284 111.64 µM -1.92371750775453 0.0312581737418612 no 3256 0.0271950011473381 1045 3906265 SGTC_1923 st058458 19.1 µM -1.92735438338459 0.0310139843274608 no 3257 0.0269677402082118 1057 3534982 SGTC_2148 5546263 113.568 µM -1.92794309598128 0.0309746054445547 no 3258 0.02693110225092 1062 792097 SGTC_2915 7971052 15.16 µM -1.94248418159476 0.0300150126571772 no 3259 0.0260392565389322 1038 5741558 SGTC_2252 omeprazole 400 µM -1.94780168386407 0.0296703139830962 no 3260 0.0257193486184945 1078 4594 A proton pump inhibitor. SGTC_1811 st050069 61.5 µM -1.94803862556922 0.0296550313781537 no 3261 0.0257051707931326 1069 3877702 SGTC_2625 euphol 100 µM -1.95922531048893 0.0289408968633626 no 3262 0.0250432031191953 1049 6708538 A triterpene alcohol. SGTC_1270 0831-1170 17.3 µM -1.96198356380989 0.0287670294421323 no 3263 0.0248821989287117 1055 6764716 SGTC_1553 gossypol 38.6 µM -1.96764625052834 0.0284128010831454 no 3264 0.0245543771107873 1062 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3142 9086498 49.47 µM -1.97128419556546 0.0281871505780255 no 3265 0.0243456890358195 1019 25236367 SGTC_791 1348-1292 225 µM -1.97182283213699 0.0281538677528889 no 3266 0.0243149174738169 1077 5437054 SGTC_3125 9127534 49.47 µM -1.97740060081421 0.0278111323137693 no 3267 0.0239981830616317 1052 1639235 SGTC_1009 4106-0057 9.87 µM -1.98117856404714 0.0275809692374499 no 3268 0.0237856261243819 1054 2928005 SGTC_1303 1160-0052 261 µM -1.98937505698328 0.0270870742645963 no 3269 0.0233299103359677 1062 3562476 SGTC_1432 4049-0298 68.4 µM -1.99442097424755 0.0267867095077026 no 3270 0.0230530341302304 1076 741646 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.9986626769185 0.02653637306235 no 3271 0.0228224319376973 1058 1241132 A phosphatase inhibitor. SGTC_2237 6667747 47.222 µM -2.0064231094503 0.0260834277738468 no 3272 0.0224055623843822 1074 729940 YDL015C TSC13 SGTC_1201 1889-3372 45.9 µM -2.00745518907905 0.0260236794359567 no 3273 0.022350608721919 1049 5392199 SGTC_916 4466-0038 42 nM -2.03215442434592 0.0246276086065878 no 3274 0.021069012567596 1064 5722064 YGL116W CDC20 SGTC_1140 3229-1848 2.98 µM -2.05225863542508 0.0235381606113015 no 3275 0.0200722668561324 1059 2849525 SGTC_611 3453-1652 23.7 µM -2.05544254368496 0.0233693994242542 no 3276 0.0199181399332157 1078 1560575 SGTC_2999 9069765 71.4286 µM -2.06479040992641 0.0228797939486514 no 3277 0.0194714178265485 1050 2097066 SGTC_427 1354-0053 47.3 µM -2.07805246318855 0.0222000270233982 no 3278 0.0188522636613942 1069 6813657 SGTC_735 3076-0345 636 µM -2.08126353676974 0.0220380256795806 no 3279 0.0187048953745899 1069 2888990 SGTC_454 lyso-paf C-16 6.67 µM -2.08498361511746 0.0218515935037415 no 3280 0.0185353939240897 1073 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2407 paclitaxel 400 µM -2.08858255871347 0.021672501347585 no 3281 0.0183726582770189 1062 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2918 7977171 22.06 µM -2.09285565093393 0.0214614737996112 no 3282 0.0181810211037954 1060 2236483 SGTC_610 4215-0184 155 µM -2.09899041343366 0.0211615460391021 no 3283 0.0179088729086752 1037 5605015 SGTC_3012 9080433 71.4286 µM -2.10813793546334 0.0207209146468251 no 3284 0.0175095299492079 1061 17688859 SGTC_822 1487-0950 154 µM -2.1248648152696 0.0199352720435932 no 3285 0.0167989472987535 1057 1958375 SGTC_2493 resveratrol 26.09 µM -2.13652821172174 0.0194025362483589 no 3286 0.0163181919919304 1068 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1449 4112-4002 201 µM -2.15307241604868 0.0186676447687565 no 3287 0.0156564938593428 1072 2059539 SGTC_1079 idarubicin 2.36 µM -2.15826535022861 0.0184419169656421 no 3288 0.01545360353343 1076 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1089 terbinafine 2.25 µM -2.16097371183948 0.0183251144016561 no 3289 0.0153486850724242 1070 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2143 5623677 140.463 µM -2.168147066053 0.0180187927085211 no 3290 0.0150737493961204 1059 5375313 SGTC_2156 5649887 115 µM -2.169506800288 0.0179612232618004 no 3291 0.0150221143224801 1078 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1872 amphotericin b 148 nM -2.17009256389056 0.0179364711429308 no 3292 0.0149999172038459 1070 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1306 1185-0270 9.02 µM -2.17025112650672 0.0179297759010348 no 3293 0.0149939134307449 1070 1548076 SGTC_2693 st077581 40.7 µM -2.17094610208557 0.0179004559766681 no 3294 0.0149676234192518 1033 25238761 SGTC_2692 st077426 47.7 µM -2.17279829610814 0.0178225144699088 no 3295 0.0148977508078489 1070 25238571 SGTC_910 3454-3003 490 µM -2.17761847926634 0.0176210338670262 no 3296 0.0147172263046662 1058 820824 SGTC_443 clozapine 122 µM -2.17765298377955 0.0176195986369533 no 3297 0.014715940862303 1085 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_111 0083-0039 52.457 µM -2.18055838127095 0.0174991047490232 no 3298 0.0146080481328816 1075 759313 SGTC_490 phenamil 164 µM -2.19747252950771 0.0168115152980804 no 3299 0.0139933581440044 1001 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_3157 9099274 49.47 µM -2.19934300633013 0.0167369156509477 no 3300 0.0139267709463847 1064 17217662 SGTC_383 2324-0395 7.37 µM -2.20729251405657 0.0164230190805049 no 3301 0.0136468149808957 1018 3146421 SGTC_2335 9018011 154.17 µM -2.21007859901936 0.0163142062616908 no 3302 0.0135498539235216 1066 6458208 SGTC_1456 k015-0012 13 µM -2.21051723734049 0.0162971312667658 no 3303 0.0135346427804203 1069 2989616 SGTC_2898 9056270 58.44 µM -2.21114550765505 0.0162727010789679 no 3304 0.0135128812366896 1061 19154699 SGTC_2986 9022445 71.43 µM -2.21522923882891 0.0161146692139404 no 3305 0.0133721669704268 1054 6459286 SGTC_933 2914-0560 114 µM -2.26906612520776 0.0141511848003764 no 3306 0.0116321524898091 1073 463887 SGTC_1624 st003710 6.25 µM -2.30005684717507 0.0131172206822941 no 3307 0.0107224998148714 1074 24207033 SGTC_1035 k081-0041 55.2 µM -2.30594677227621 0.0129282749135094 no 3308 0.0105568033515575 1083 731709 SGTC_3162 9099653 49.47 µM -2.30794172247749 0.0128648137282337 no 3309 0.010501189034425 1080 25237511 SGTC_2970 9090938 41.86 µM -2.30943977466905 0.012817336610248 no 3310 0.0104595950151416 1067 17217104 SGTC_85 0868-0259 160.055 µM -2.31009528135709 0.0127966096372572 no 3311 0.0104414398149103 1066 83173 SGTC_2886 9058944 51.95 µM -2.31701391121825 0.0125796062715357 no 3312 0.0102514869912416 1085 4949929 SGTC_2483 5729050 27.16 µM -2.32066614595277 0.012466343603294 no 3313 0.0101524346038606 1069 2865180 SGTC_893 0958-0369 48.9 µM -2.32798413459841 0.0122420540299765 no 3314 0.00995647306581879 1069 6819948 SGTC_1332 1480-0653 17.5 µM -2.34339398655292 0.011781165031575 no 3315 0.00955459602360322 1074 5749438 SGTC_2331 7980721 200 µM -2.34432463908246 0.0117538190424005 no 3316 0.00953078593517043 1065 2981221 SGTC_1034 k072-0165 12.7 µM -2.34506941716918 0.0117319744256035 no 3317 0.00951176869780341 1081 5835461 SGTC_3183 9108214 49.47 µM -2.44093892047242 0.00919849712716441 no 3318 0.00732456609558876 1092 4974831 SGTC_1758 st042942 75.2445 µM -2.47123926252906 0.00850427220930758 no 3319 0.00673228495078403 1085 669317 SGTC_1508 1080-0625 72.9 µM -2.4852930211766 0.00819819432732227 no 3320 0.00647224184625331 1055 767111 SGTC_1220 1838-0075 193 µM -2.49194145633527 0.0080568003283399 no 3321 0.00635234881461299 1078 5529645 SGTC_385 1494-0393 12.4 µM -2.49994453180993 0.00788944350017569 no 3322 0.00621063765629416 1080 3090647 SGTC_1579 chlormadinone acetate 49.4 µM -2.50050743454731 0.00787778825469241 no 3323 0.0062007765002451 1082 45114258 A steroidal progestin. SGTC_2476 5806916 10.51 µM -2.5178367089522 0.00752630768417344 no 3324 0.0059039024425032 1075 2870194 SGTC_2004 4023728 41.89 µM -2.52090682373205 0.00746549950527077 no 3325 0.00585264213366956 1073 360084 YDR527W RBA50 SGTC_1938 st074717 56.4 µM -2.53435120086854 0.00720428252014504 no 3326 0.00563278804774495 1070 17250979 SGTC_80 0159-0065 512.242 µM -2.53678372337733 0.00715789087875664 no 3327 0.00559380231721928 1088 1548079 SGTC_154 3389-1638 511.116 µM -2.54746756366479 0.00695724101183221 no 3328 0.00542539699980185 1084 5238686 SGTC_1924 st058459 75.1 µM -2.55881601293488 0.00674956352684065 no 3329 0.00525146559965863 1081 688683 SGTC_2973 9094665 17.96 µM -2.5833560973004 0.00631911133419314 no 3330 0.00489221376099638 1075 25237061 YIL048W NEO1 SGTC_1705 st027868 56.3335 µM -2.5917154373178 0.00617813230788216 no 3331 0.00477493635341202 1080 292948 SGTC_1751 st044839 27.194 µM -2.62015872791347 0.00571908242565815 no 3332 0.00439444243329649 1083 5291326 SGTC_2935 9038016 29.96 µM -2.62414511358138 0.00565722561542164 no 3333 0.00434333830608661 1070 6463195 SGTC_2814 7977482 42.97 µM -2.63642710055989 0.00547036376107398 no 3334 0.00418921003924352 1077 6456762 SGTC_3314 9135860 59.4275 µM -2.64520061071868 0.00534025994146524 no 3335 0.00408212492612969 1076 25252478 SGTC_1008 4106-0037 6 µM -2.66955584269551 0.00499339731343373 no 3336 0.00379758211324637 1088 2905394 SGTC_1946 st076057 65.1 µM -2.68214247089429 0.00482212737122096 no 3337 0.00365761492162656 1086 953009 SGTC_393 acivicin 6.25 µM -2.72023438253754 0.00433526146915922 no 3338 0.00326178292717298 1056 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1343 1487-0095 224 µM -2.74588368491779 0.00403267191026657 no 3339 0.0030174077610496 1086 4560101 YGL055W OLE1 SGTC_56 0957-0365 83.25 µM -2.75870123540223 0.0038886646895819 no 3340 0.00290157815190954 1091 6752360 SGTC_1138 3761-0006 1.03 µM -2.80540641677425 0.00340210747033874 no 3341 0.00251265858688311 1091 12061087 SGTC_84 0443-0269 128.823 µM -2.88892399279871 0.00266655511337798 no 3342 0.00193281249436663 1087 6150058 SGTC_1499 4480-0877 67.3 µM -2.89447039561499 0.00262321606881597 no 3343 0.00189899360758415 1087 2861909 SGTC_634 1611-4317 11.2 µM -2.91649405489078 0.00245733563379379 no 3344 0.00176994734642993 1095 2843522 SGTC_1088 bifonazole 369 nM -2.91924097068255 0.00243732574784246 no 3345 0.00175442435180024 1090 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1315 1237-0019 3.69 µM -2.93087604249425 0.00235419455524309 no 3346 0.00169003812757097 1093 825140 SGTC_335 4077-0256 27.6 µM -3.1014490621913 0.00139693473573628 no 3347 0.000962880007374902 1082 3121989 SGTC_2794 7785382 27.27 µM -3.10232012589317 0.00139312814913145 no 3348 0.000960050980385203 1079 2205081 SGTC_1012 4112-3522 18 µM -3.11278705823737 0.00134812226017837 no 3349 0.000926648418971174 1092 3112398 SGTC_386 1509-0011 3.07 µM -3.11900009031418 0.00132203977652673 no 3350 0.000907329528389859 1090 3107280 SGTC_3205 9113483 49.47 µM -3.15577885220761 0.00117686235082421 no 3351 0.000800350877876068 1086 17018033 SGTC_2602 kawain 100 µM -3.21413486618717 0.000976204963204417 yes 3352 0.00065419101712206 1086 5369129 SGTC_1086 cerivastatin 2.18 µM -3.30490960767214 0.000725679995622963 yes 3353 0.000475035179796948 1087 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_321 4534-3890 65.3 µM -3.47288824113942 0.000411455864772744 yes 3354 0.000257444855516995 1095 699746 SGTC_2967 9089538 49.85 µM -3.4874006101274 0.000391327133060685 yes 3355 0.000243870085048175 1094 728216 SGTC_436 n,n-dimethylsphingosine 3.3 µM -3.67242546864866 0.000203192536439691 yes 3356 0.000120129617582751 1091 5282309