SGTCid condition conc unit PRP9|YDL030W.score PRP9|YDL030W.strain.pval PRP9|YDL030W.strain.significant PRP9|YDL030W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2510 benzyl isothiocyanate 8.31 µM 5.57770568944839 4.51794485153182e-09 yes 1 1.21855764913983e-08 9 2346 DNA damaging agent; causes G2/M arrest.
SGTC_520 3584-0023 682 µM 5.4829571528082 8.00679051049405e-09 yes 2 2.09137175925893e-08 6 1340790
SGTC_2774 tamoxifen 10.92 µM 5.0050710722696 1.24638688980142e-07 yes 3 2.79207119107379e-07 4 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1122 capsaicin 818.572 nM 4.65761352030845 7.91516790383435e-07 yes 4 1.59948016846221e-06 1 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2779 methotrexate 400 µM 4.47604632886437 1.97978308663338e-06 yes 5 3.80189957729555e-06 14 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1053 3366-3204 134 µM 4.21892226411431 6.84651816228014e-06 yes 6 1.22736441524474e-05 6 3632071 YPR165W RHO1
SGTC_2012 4023501 200 µM 4.21002876975311 7.1381339560458e-06 yes 7 1.27669085636925e-05 10 3477460
SGTC_1027 k015-0025 8.67 µM 4.15384313360948 9.27300906979559e-06 yes 8 1.63468672414824e-05 3 3598955
SGTC_3058 9093861 49.47 µM 3.84875679265293 3.63064379758074e-05 yes 9 5.93594012261037e-05 6 17217477
SGTC_95 0471-0001 561.058 µM 3.78714542368897 4.72853767804736e-05 yes 10 7.6193960143362e-05 5 4015405
SGTC_661 1304-0007 33.6 µM 3.73333581713045 5.93716969090672e-05 yes 11 9.44801926792774e-05 5 3117130
SGTC_1045 1348-1485 165 µM 3.7224555023032 6.21460308211873e-05 yes 12 9.86473433638332e-05 5 6810614
SGTC_944 3370-0224 231 µM 3.71670674001846 6.3660787599512e-05 yes 13 0.000100918245429645 6 4580514
SGTC_2086 5274770 176.623 µM 3.67174167405852 7.67674872796852e-05 yes 14 0.000120451560958126 13 689278
SGTC_873 0591-4978 488 µM 3.64864449340624 8.44496265622894e-05 yes 15 0.00013181380739035 5 3305145
SGTC_1841 st054148 70 µM 3.62093094861704 9.46213427613854e-05 yes 16 0.000146772429762889 5 675442
SGTC_1743 st037606 46.3785 µM 3.58821841533218 0.000108108089705051 yes 17 0.000166472660853222 12 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2881 9058953 51.95 µM 3.58038842915156 0.000111593864844431 yes 18 0.000171541907637533 9 17122249
SGTC_572 0960-0087 17.7 µM 3.5671127401896 0.000117746147580094 yes 19 0.000180468109964938 14 6796365
SGTC_583 1488-1091 88.9 µM 3.46009033432143 0.00018031283014336 yes 20 0.000269997100873494 9 4303273
SGTC_21 0849-0113 22.993 µM 3.40436295907461 0.000224091671210117 yes 21 0.000331592839160653 10 1560156
SGTC_2305 7443522 69.23 µM 3.38354111223801 0.000242856921003098 yes 22 0.000357787466010935 12 5415886
SGTC_37 0566-0070 1.56 µM 3.37738935186669 0.000248675437878092 yes 23 0.000365886938022531 8 1626686
SGTC_6 0844-0013 19.835 µM 3.36045159884251 0.000265374233921157 yes 24 0.000389075819315828 19 1584900
SGTC_2002 4023503 131 µM 3.35867018891085 0.000267189964788534 yes 25 0.000391592393568947 19 4736863 YCR052W RSC6
SGTC_2168 5727979 200 µM 3.35628290591066 0.000269641396315615 yes 26 0.000394988571635294 9 695210
SGTC_936 3005-4620 401 µM 3.34354054610705 0.000283084399463088 yes 27 0.000413583027669571 6 777207
SGTC_719 2810-4230 27.3 µM 3.34004148916643 0.000286883615031969 yes 28 0.000418829373576489 3 721079
SGTC_3081 9117243 49.47 µM 3.28886134583578 0.000348165554169112 yes 29 0.000502967830364159 41 45595589
SGTC_2663 amphotericin b 100 µM 3.25827072572653 0.000390390395367085 yes 30 0.000560467067427519 14 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2860 9025725 38.96 µM 3.20609350919818 0.00047354259633242 yes 31 0.000672751284164651 8 40546248
SGTC_1942 st076330 65.2 µM 3.17198831614307 0.000536460274081668 yes 32 0.000756995490064682 8 24208414
SGTC_141 0443-0274 32.331 µM 3.17148528103492 0.000537443624903514 yes 33 0.000758307767814597 8 1627241
SGTC_2338 7999974 200 µM 3.1512731917923 0.000578362196160899 yes 34 0.000812801811407479 20 315925
SGTC_1030 k029-0042 36.7 µM 2.996914382845 0.000999453686130552 yes 35 0.00136363648668395 14 6080581
SGTC_2800 7887935 81.82 µM 2.93043757661034 0.00125579425214859 no 36 0.00169242496411365 22 2961002
SGTC_1952 st077036 64.1 µM 2.90339422426919 0.00137630307323545 no 37 0.00184570822107641 25 2937007
SGTC_88 0180-0332 8.668 µM 2.84245889286178 0.00168747271765087 no 38 0.0022383501878184 21 3101745
SGTC_573 3702-0553 84.7 µM 2.83314153793986 0.00174033374902355 no 39 0.0023046486040249 17 1222756
SGTC_571 k831-0106 44.2 µM 2.83205453554923 0.00174659791504311 no 40 0.00231249798820331 23 4783639
SGTC_864 0469-0573 172 µM 2.81960323972416 0.00181983008211977 no 41 0.00240415304219958 15 689425
SGTC_2664 lyso-paf C-16 73.48 µM 2.7961721609039 0.00196525636307773 no 42 0.00258559228450476 27 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1084 voriconazole 435 nM 2.76615688884027 0.00216694518691979 no 43 0.00283606194553467 23 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1046 2001-0062 216 µM 2.68129054732521 0.00284274849646471 no 44 0.00366694046049695 18 739778
SGTC_2153 5569715 200 µM 2.67401721507658 0.00290870524929753 no 45 0.00374743020141042 21 2054701
SGTC_2586 curcumin 80 µM 2.6694813963589 0.00295053272285511 no 46 0.0037984240715303 34 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1912 st060209 90.8 µM 2.65259664293854 0.0031110440397516 no 47 0.00399376291302302 30 688787
SGTC_2736 butenafine 14.65 µM 2.64518475153827 0.00318395411209613 no 48 0.00408231626444088 28 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2823 7987624 58.44 µM 2.63588752050784 0.00327758243315839 no 49 0.0041958771727717 41 2239440
SGTC_1783 st039459 87.517 µM 2.62924409383092 0.00334599456908231 no 50 0.00427874560391601 25 729761
SGTC_2762 leflunomide 42.06 µM 2.6223787558387 0.00341803798504123 no 51 0.00436591652271117 27 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_856 0433-0016 11.3 µM 2.62050382697591 0.0034379539031132 no 52 0.00438999723265142 18 3911780
SGTC_2786 7743617 45.45 µM 2.61907394137694 0.00345321247893301 no 53 0.00440844170616024 19 583674
SGTC_623 k072-0108 16.9 µM 2.60310158534477 0.00362783843660469 no 54 0.00461922876249692 41 5382803
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 2.60031723097177 0.00365907831595627 no 55 0.00465688086178034 31 551469
SGTC_574 1315-0397 40 µM 2.59602733923882 0.00370768256750509 no 56 0.00471542804847379 28 6794277
SGTC_2303 7774051 200 µM 2.58583435500064 0.00382549890769922 no 57 0.00485718015644525 29 2953184
SGTC_2897 9048598 12.99 µM 2.57400146986877 0.00396647074279205 no 58 0.00502649230701341 11 6467404
SGTC_1951 sophoraflavanone G 9.2 µM 2.57142187138091 0.00399781383216905 no 59 0.00506409326000356 24 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_3068 9116768 49.47 µM 2.5662607138067 0.00406119038453152 no 60 0.00514007636836427 19 41904888
SGTC_847 0342-0274 5.54 µM 2.5599314413662 0.00414013759160067 no 61 0.00523464072088536 22 18097
SGTC_3266 9136860 49.47 µM 2.55425217490415 0.00421214292099169 no 62 0.00532080769834176 42 4871271 YPR165W RHO1
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 2.53334641442197 0.00448694616255378 no 63 0.00564896191992343 28 5355888
SGTC_581 0958-0271 211 µM 2.52130479762718 0.00465239923860706 no 64 0.00584602633411074 26 4591145
SGTC_1675 st018485 24.5 µM 2.49902297421031 0.00497296575944389 no 65 0.00622681185691051 36 3323024
SGTC_303 1348-1668 34.2 µM 2.48726900258479 0.00514987510606367 no 66 0.00643640107367433 27 5380509
SGTC_326 k292-0812 17.5 µM 2.47541072286188 0.00533400889904279 no 67 0.00665415149231921 29 3579357
SGTC_2899 9053889 58.44 µM 2.47411250156029 0.00535451888423657 no 68 0.00667838144749876 16 6470052
SGTC_2865 9030313 51.95 µM 2.47375779043075 0.00536013498112492 no 69 0.00668501531308496 12 42562754
SGTC_1401 3807-4679 7.6 µM 2.46881707231649 0.00543890707473322 no 70 0.00677802483220887 27 3291456
SGTC_2020 4017018 200 µM 2.46720512144511 0.00546482882470813 no 71 0.00680861635925236 32 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1924 st058459 75.1 µM 2.43394452079472 0.00602476372646923 no 72 0.0074676420343764 21 688683
SGTC_3195 9113082 49.47 µM 2.40846341483973 0.00648754971048353 no 73 0.00800991591367545 13 17018038
SGTC_2415 st077333 57.7 µM 2.40817144944754 0.00649302974250622 no 74 0.00801632489495919 55 2766255
SGTC_2514 salinomycin 42.74 µM 2.38691223453192 0.00690322263708195 no 75 0.0084952734351403 35 23682228 A polyether potassium ionophore.
SGTC_1586 deoxycorticosterone acetate 53.7 µM 2.38417454363852 0.00695767530292951 no 76 0.00855874070930243 14 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_29 0299-0004 12.984 µM 2.36557258766131 0.00733781373240924 no 77 0.00900110695646848 15 16871 A napthoquinone isolated from Swertia calycina.
SGTC_909 3448-9333 149 µM 2.34339121346311 0.00781493610797391 no 78 0.00955466704878316 23 3344074
SGTC_1217 1183-1422 255 µM 2.31712805912222 0.00841497624259951 no 79 0.0102483784688292 29 2849664
SGTC_1587 estradiol valerate 56.1 µM 2.30253305583115 0.0087656147035104 no 80 0.0106525647449436 28 13791 A steroid.
SGTC_3179 9107801 49.47 µM 2.28156469044188 0.00929177193915986 no 81 0.0112575266799353 27 4818259
SGTC_881 0833-0569 170 µM 2.28095568043504 0.00930745816187293 no 82 0.0112755347899736 40 5418700
SGTC_578 3460-0051 92 µM 2.27779436581419 0.00938925674501536 no 83 0.0113694160887368 37 2876744
SGTC_2641 levomentholum 100 µM 2.27093729332859 0.00956884666070175 no 84 0.0115753871246746 17 16666
SGTC_922 1866-0035 480 µM 2.26660068235948 0.00968396825687816 no 85 0.0117073151875533 47 3156169
SGTC_3075 9116269 49.47 µM 2.26263976114591 0.00979017227139894 no 86 0.0118289524914692 40 17015205 YNL244C SUI1
SGTC_98 0074-0023 107.663 µM 2.25781675224923 0.00992086390594286 no 87 0.0119785431809472 28 3563821
SGTC_2682 pyrogallin 40.03 µM 2.25526151480737 0.00999071985969492 no 88 0.0120584593804949 38 822798 An ATP competetive kinase inhibitor.
SGTC_2955 9076254 12.21 µM 2.25017710807983 0.0101309971987733 no 89 0.0122188524261689 35 16459619
SGTC_3168 9103419 49.47 µM 2.24409006546699 0.0103011945389103 no 90 0.0124133035168045 15 16649256
SGTC_2316 5844804 197.44 µM 2.23578718695757 0.0105373648498705 no 91 0.0126828573233217 48 776813
SGTC_802 4112-3352 742 µM 2.2314951621817 0.0106612883294702 no 92 0.0128241738093245 31 704594
SGTC_1460 k062-0059 9.15 µM 2.21810804452921 0.011056002987221 no 93 0.0132737332252118 31 1373085
SGTC_2583 asiatic acid 100 µM 2.21758682586142 0.0110716247005866 no 94 0.0132915084842684 51 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_87 0100-0052 35.5 µM 2.20904145741166 0.0113304933561148 no 95 0.0135858787251623 64 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2401 5128683 200 µM 2.20136119893558 0.0115676268550439 no 96 0.0138552317807339 45 708373
SGTC_2184 6075246 200 µM 2.19425840784475 0.011790754489017 no 97 0.0141084188575868 35 2267320
SGTC_1071 trifluoperazine 6.31 µM 2.19391318289266 0.0118016939428183 no 98 0.0141208257416706 37 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_616 4092-0450 108 µM 2.19098360971546 0.0118948809707362 no 99 0.0142264892780897 31 787165
SGTC_1949 st076024 69.1 µM 2.18947351011206 0.0119431646790539 no 100 0.0142812209276904 40 2921930
SGTC_908 3448-7491 47.7 µM 2.18635541663835 0.0120434002893814 no 101 0.0143948063506798 42 1203031
SGTC_2478 5763493 32.33 µM 2.18246253551655 0.0121695657311889 no 102 0.0145377066774606 47 1365576 YLR208W SEC13
SGTC_1073 triclabendazole 3.09 µM 2.18042972588393 0.0122359017324765 no 103 0.0146128113424582 32 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1612 st002233 45.4 µM 2.17707298977833 0.0123461269569237 no 104 0.014737560985098 33 1035021
SGTC_192 3455-0609 60.9 µM 2.16577688180708 0.0127233987176986 no 105 0.0151641203767963 33 3769639
SGTC_3065 9113888 49.47 µM 2.15975795057125 0.0129284651099562 no 106 0.0153957062058549 42 16648368
SGTC_3009 9080819 71.4286 µM 2.15857640299952 0.0129690545824147 no 107 0.0154415225364515 47 17027216
SGTC_2834 9001755 58.44 µM 2.15844510236951 0.0129735719222918 no 108 0.0154466211401329 45 2989575
SGTC_454 lyso-paf C-16 6.67 µM 2.14439918918924 0.0134647388985227 no 109 0.0160004575896045 38 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_799 1310-0557 151 µM 2.1425750253715 0.0135296906598176 no 110 0.0160736191721507 52 5354492
SGTC_801 0866-0028 10.1 µM 2.14253394608424 0.0135311564504515 no 111 0.0160752700309548 47 6849771
SGTC_1473 k844-0725 134 µM 2.14195341282244 0.0135518856922779 no 112 0.0160986155397815 58 54682906
SGTC_1376 2910-0861 41.3 µM 2.14164702256152 0.0135628370899329 no 113 0.0161109483973343 40 1112859
SGTC_1339 1486-1321 22.7 µM 2.13943778315932 0.0136420289258252 no 114 0.0162001148501539 51 3469382
SGTC_1121 fusaric acid 630.51 nM 2.13088303438907 0.013952455545118 no 115 0.0165493897018259 38 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_3126 9127922 49.47 µM 2.12909290093918 0.0140181791934147 no 116 0.0166232874988233 89 45595682
SGTC_2400 5203494 178.7 µM 2.12093180492733 0.0143212009439684 no 117 0.016963770849367 65 6777674
SGTC_236 1509-0011 5.31 µM 2.11919681687643 0.0143863432627903 no 118 0.0170369185994343 85 3107280
SGTC_2468 5987765 72.9 µM 2.11695193404231 0.0144710087268081 no 119 0.0171319636768293 34 26772094
SGTC_2978 9011784 42.97 µM 2.11552240922443 0.0145251463118675 no 120 0.0171927235294739 36 2994934
SGTC_333 3486-0131 40.1 µM 2.11382572219164 0.0145896277582482 no 121 0.0172650775849846 34 6744690
SGTC_1916 st067606 49.2 µM 2.09714619855106 0.0152367440529432 no 122 0.0179903177150639 63 19590279
SGTC_2212 7123476 200 µM 2.08732120897353 0.0156293458892972 no 123 0.0184295544342661 16 1085715
SGTC_2071 5230951 39.92 µM 2.08547286054022 0.0157041670779232 no 124 0.0185131995830362 46 1799272
SGTC_1670 st016595 4.04 µM 2.08439763079882 0.0157478336107498 no 125 0.0185620065842161 37 597879
SGTC_2297 7971671 152.32 µM 2.08433554213423 0.015750358292827 no 126 0.0185648282653986 46 909016
SGTC_3309 9129340 25.759 µM 2.08080900402386 0.015894327254095 no 127 0.0187256958423575 38 17158987
SGTC_3084 9116877 49.47 µM 2.07923333908172 0.0159590167163905 no 128 0.0187979543751902 26 27241325
SGTC_2692 st077426 47.7 µM 2.0691400284679 0.016378777918929 no 129 0.019266474216919 62 25238571
SGTC_1736 st036774 51 µM 2.0678998785444 0.0164309997767403 no 130 0.0193247194256329 46 1272247
SGTC_2213 7173844 200 µM 2.05377436372975 0.0170359443252539 no 131 0.0199987676406567 39 892728
SGTC_2066 5222451 176 µM 2.0519125402223 0.0171170821970333 no 132 0.0200890814592613 83 2281147
SGTC_2976 9009005 19.48 µM 2.04270693295433 0.0175231307359722 no 133 0.0205407290548543 31 2993148
SGTC_1961 st076550 68.7 µM 2.03944749460405 0.0176688585864258 no 134 0.0207026931938154 55 1579337
SGTC_2575 plumbagin 510 nM 2.03505182789136 0.0178670235257571 no 135 0.0209228291655074 75 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2419 paclitaxel 166.5 µM 2.03011417446753 0.0180918798800579 no 136 0.0211724675232107 56 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_136 0097-0015 404.482 µM 2.02194274214537 0.0184692986683597 no 137 0.0215911337196556 53 4861337
SGTC_495 decylubiquinone 155 µM 2.0202972010927 0.0185461079191449 no 138 0.0216762844821278 43 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_96 0929-0093 37.281 µM 2.01878769684504 0.018616806367013 no 139 0.0217546451777722 58 6991579
SGTC_165 k038-0023 64.381 µM 2.01696014688305 0.0187027075658413 no 140 0.0218498362199164 66 46368543
SGTC_118 0083-0097 135.343 µM 2.00312706712666 0.0193639156586323 no 141 0.0225818256999189 89 5207356
SGTC_2408 sulbentine 18.36 µM 1.99413850737687 0.0198041225509844 no 142 0.0230684600146691 80 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2706 st078239 82.5 µM 1.99211915057558 0.0199041788635167 no 143 0.0231789931155847 51 15434492
SGTC_1596 piperlongumine 63 µM 1.98966732956713 0.0200262394487716 no 144 0.0233137969385897 45 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2183 6420625 130.508 µM 1.97813494646428 0.0206089144326056 no 145 0.0239567425609624 72 2897619
SGTC_2469 5655019 90.81 µM 1.97744799179124 0.0206440714781937 no 146 0.0239955068829932 42 2788239
SGTC_3160 9100216 49.47 µM 1.97261267666796 0.0208929737631495 no 147 0.0242698538102283 31 17191039
SGTC_1419 3993-2473 62.6 µM 1.96030276527334 0.0215381277234972 no 148 0.0249802065089203 46 704026
SGTC_1080 nisoldipine 24.4 µM 1.95595196944254 0.0217701411587542 no 149 0.0252354062063397 62 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_831 k061-1017 217 µM 1.95261167289244 0.021949697490074 no 150 0.0254328134711204 80 1240153
SGTC_2404 5161160 200 µM 1.95089805001706 0.0220422968698568 no 151 0.0255345873358729 74 2831543
SGTC_1941 st076221 61.8 µM 1.94932252711984 0.0221277244756253 no 152 0.0256284599958063 67 2828568
SGTC_1431 4049-0260 9.09 µM 1.94896918983625 0.022146921353552 no 153 0.0256495521212878 56 3854841
SGTC_1179 1021-1431 9.29 µM 1.94763997975541 0.0222192635111889 no 154 0.0257290282267011 58 2840958
SGTC_2386 9075165 157.42 µM 1.94565180618631 0.0223278418121411 no 155 0.0258482897196094 53 16452277
SGTC_1483 3453-0561 55.9 µM 1.94545763670552 0.0223384697623518 no 156 0.0258599618183883 56 4546991
SGTC_27 0485-0001 32.618 µM 1.94409498988792 0.022413174946049 no 157 0.0259419986657522 41 2054479
SGTC_1762 st045503 25.4615 µM 1.93169958442132 0.0231024620302183 no 158 0.0266982980547516 46 4645554
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.92061275109125 0.0237340212978558 no 159 0.0273902732098814 46 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1130 3454-2858 15.9 µM 1.91724744608681 0.023928573580266 no 160 0.0276032515027535 77 715628 YIL048W NEO1
SGTC_663 1486-0733 13.9 µM 1.89954801970251 0.0249739915843915 no 161 0.0287462296083041 60 722445 YPR165W RHO1
SGTC_825 1988-2224 89.6 µM 1.89221211954668 0.0254183761967054 no 162 0.0292313621175736 68 1180859
SGTC_476 mead acid 10 µM 1.89039911090008 0.025529217244672 no 163 0.0293523011234236 40 5312531 An omega 9 fatty acid.
SGTC_200 k038-0079 37.545 µM 1.88715764751343 0.0257283977485656 no 164 0.0295695624453036 67 3436683
SGTC_1763 st044482 94.5 µM 1.87885999093272 0.0262442034949183 no 165 0.0301318065342221 71 88505
SGTC_1492 4158-0558 28.5 µM 1.87818029774507 0.0262868355628643 no 166 0.030178252241771 41 3967268
SGTC_2268 7933382 153.85 µM 1.87775635384307 0.0263134556962478 no 167 0.030207251785873 66 935025 YOR257W CDC31
SGTC_2385 9074692 200 µM 1.87050202669624 0.0267724697312751 no 168 0.0307070679116839 59 17046906
SGTC_297 0986-0032 24 µM 1.86668202176869 0.0270168540402809 no 169 0.0309730029060342 63 2847425
SGTC_2810 7959871 45.46 µM 1.85620061219105 0.0276969799706408 no 170 0.0317124844410566 73 2974535
SGTC_3111 9122088 49.47 µM 1.84740423277842 0.0282787237766794 no 171 0.0323442880988868 46 16876704
SGTC_3132 9126706 49.47 µM 1.84716258626114 0.0282948473831169 no 172 0.0323617899991425 70 850858
SGTC_3073 9114972 49.47 µM 1.84270799810434 0.0285934482199678 no 173 0.0326858278162846 48 41905075
SGTC_1946 st076057 65.1 µM 1.8405545769707 0.0287387338594233 no 174 0.0328434296969787 44 953009
SGTC_1778 st046819 58.9 µM 1.84009076440752 0.0287701062762508 no 175 0.0328774564896495 76 671715
SGTC_123 0083-0120 66.675 µM 1.83650803178126 0.0290134040759672 no 176 0.0331412776610283 76 16001701
SGTC_426 0988-0037 14.6 µM 1.8322910310746 0.0293019621456296 no 177 0.0334540363151611 81 5383008
SGTC_1294 1000-1494 117 µM 1.82530232231573 0.0297854268034395 no 178 0.0339777099661978 64 712797 YDL207W GLE1
SGTC_1725 st036284 20.55 µM 1.8193811526361 0.0302002029400563 no 179 0.03442665005333 56 707914
SGTC_1477 0139-0234 16 µM 1.8191719922147 0.0302149416732281 no 180 0.034442597191237 61 620880
SGTC_2851 9015922 71.43 µM 1.81800657162443 0.0302971735938466 no 181 0.0345315641838791 75 2996893
SGTC_2748 diazoxide 86.69 µM 1.81547161549056 0.0304766803253162 no 182 0.0347257320797494 29 3019 A potassium channel activatior.
SGTC_2957 9076800 11.52 µM 1.81398530431126 0.0305823389506032 no 183 0.0348399941414398 53 16459615
SGTC_2334 9017922 200 µM 1.81025896305039 0.0308485707968354 no 184 0.0351278188403488 50 3163164
SGTC_1906 st060206 94.7 µM 1.80910648457099 0.0309312980602343 no 185 0.0352172309308895 70 5133468
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.80820879985023 0.0309958628395626 no 186 0.0352870047758764 73 688798
SGTC_2383 9036125 200 µM 1.80762153317377 0.0310381615279836 no 187 0.0353327122528945 56 79580
SGTC_2299 7976368 114.88 µM 1.80714030621531 0.0310728581546078 no 188 0.0353702027541173 61 2979718
SGTC_2891 9063876 19.48 µM 1.79699684202504 0.0318117039867158 no 189 0.0361680605522325 37 6472478
SGTC_606 k015-0008 38.6 µM 1.7949427877472 0.0319630737913734 no 190 0.0363314078974195 63 1970475
SGTC_2914 7968218 45.32 µM 1.79196161691805 0.0321838234642156 no 191 0.0365695573156967 49 2977111
SGTC_2902 5787006 60.46 µM 1.78817390990433 0.0324661092369724 no 192 0.0368739770917238 64 591003
SGTC_3213 9129884 49.47 µM 1.7859721281918 0.0326311377114745 no 193 0.0370518855436742 65 17190742
SGTC_638 3970-0837 4.09 µM 1.78313220774737 0.0328450171095508 no 194 0.0372823923289181 50 4118451 YLR208W SEC13
SGTC_315 k915-0449 187 µM 1.78054972397677 0.0330405104498705 no 195 0.037493019661152 56 20970215 YNL149C PGA2
SGTC_3178 9107506 49.47 µM 1.77876465309605 0.033176199476886 no 196 0.0376391772335452 92 8897194
SGTC_335 4077-0256 27.6 µM 1.77294570671864 0.0336217069583488 no 197 0.0381188519426404 81 3121989
SGTC_2791 5663188 71.43 µM 1.76640553938798 0.0341282971099984 no 198 0.0386639182164097 92 54690634
SGTC_3048 9093155 49.47 µM 1.75317699051234 0.035172146630756 no 199 0.0397858156571445 61 25236002
SGTC_1454 4239-0054 42.6 µM 1.74774793989062 0.0356080611212455 no 200 0.0402538417923856 78 1340767
SGTC_629 3448-6466 76.7 µM 1.74638333665574 0.0357183228397247 no 201 0.0403721817464115 68 573744
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.74500393087712 0.0358300648474707 no 202 0.0404920923611266 53 16486 A toxic proline analog.
SGTC_1184 1269-1718 139 µM 1.73550179896282 0.0366076123035112 no 203 0.0413259815659558 76 5403821
SGTC_453 enantio-paf c16 10 µM 1.72533959368802 0.0374543924864324 no 204 0.0422331452554438 105 13871343 A lipid and platelet activating factor
SGTC_893 0958-0369 48.9 µM 1.72493613153752 0.0374883389700488 no 205 0.0422694916073239 71 6819948
SGTC_2225 6654152 15.4 µM 1.72416111866314 0.0375536174617907 no 206 0.0423393805310168 94 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_153 4077-0274 519.67 µM 1.71950201944253 0.0379480070304301 no 207 0.0427615001266434 74 3121976
SGTC_17 0960-0276 49.807 µM 1.71120641828714 0.038658585755134 no 208 0.043521507139285 89 6821114
SGTC_1549 4'-methoxyflavonol 74.6 µM 1.70967354140129 0.0387910671292734 no 209 0.0436631290292336 62 97141
SGTC_3108 9121785 49.47 µM 1.70369209514951 0.0393115645445536 no 210 0.0442193128558123 80 17140271
SGTC_1100 amiodarone 5.07 µM 1.70322955295735 0.0393520499481998 no 211 0.0442625590776533 55 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_865 0488-0499 301 µM 1.68596332360936 0.0408877602773713 no 212 0.0459014319034221 66 9634651
SGTC_62 0180-0423 3.232 µM 1.68329307383658 0.0411295443464423 no 213 0.0461591852801911 92 30102 YGL099W LSG1
SGTC_665 3914-0008 307 µM 1.681385355075 0.0413029922365642 no 214 0.0463440441318086 58 1069549
SGTC_1802 st050112 57.9 µM 1.67952577737213 0.0414726333699355 no 215 0.0465248096974017 62 4662563
SGTC_3150 9097574 49.47 µM 1.67842511341227 0.0415733078242554 no 216 0.0466320692006291 67 17217476
SGTC_1829 berberine 14.4 µM 1.67662277299767 0.0417385900126282 no 217 0.046808135346276 102 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1198 1612-1005 86.7 µM 1.67633295956902 0.0417652167227693 no 218 0.0468364962004877 90 6998509
SGTC_281 1672-3440 14.9 µM 1.67351646110833 0.0420247006001408 no 219 0.0471128343741743 65 6833000
SGTC_89 0302-0250 142.109 µM 1.66508309491671 0.0428094779821814 no 220 0.0479480894589197 86 4203518 YLR208W SEC13
SGTC_2182 6325192 200 µM 1.65780921457103 0.0434958338265477 no 221 0.0486779904242082 67 736248
SGTC_3128 9127691 49.47 µM 1.65518659493362 0.0437454695467051 no 222 0.0489433267754694 64 41316314
SGTC_1199 1638-0010 4.46 µM 1.65386475055308 0.0438717275695804 no 223 0.0490774980686209 77 3111136
SGTC_1801 st050089 28.441 µM 1.64460359819144 0.0447645854117499 no 224 0.050025792179301 91 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1661 st013063 9.66 µM 1.64011027339098 0.0452030235992975 no 225 0.0504911203681879 90 721395
SGTC_1242 0402-0103 60.1 µM 1.63570771254276 0.0456359499945811 no 226 0.0509503872820507 74 432868
SGTC_819 1013-0258 27.7 µM 1.63140104626799 0.0460626656294769 no 227 0.0514028621398197 78 5753198
SGTC_3076 9116187 49.47 µM 1.63115966589636 0.0460866767562901 no 228 0.0514283167701701 64 27241210
SGTC_543 3844-1095 191 µM 1.62999790963597 0.0462023822396266 no 229 0.0515509693893307 89 4230703
SGTC_656 4090-1979 187 µM 1.62690577569468 0.0465114813242854 no 230 0.0518785555643724 79 22330961
SGTC_2973 9094665 17.96 µM 1.62689795186624 0.0465122655177603 no 231 0.0518793865279081 112 25237061 YIL048W NEO1
SGTC_3297 9117502 71.43 µM 1.61961015522721 0.0472473529234802 no 232 0.0526580233749278 46 7453720
SGTC_905 2-aminofluorene 215 µM 1.61908130285619 0.0473010562284601 no 233 0.0527148855587075 71 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2204 7233102 200 µM 1.61692893045823 0.047520127809977 no 234 0.0529468113496869 78 2172480
SGTC_3149 9097855 49.47 µM 1.61574216376623 0.0476412658331627 no 235 0.0530750353944597 68 25236625 YMR079W SEC14
SGTC_1770 st043884 66.3 µM 1.6152085411827 0.0476958153709724 no 236 0.0531327707651157 111 670149
SGTC_338 4055-0136 114 µM 1.61350192577198 0.0478706098942367 no 237 0.0533177526032327 65 2900563
SGTC_3174 9107204 49.47 µM 1.6132125093449 0.0479003032241157 no 238 0.0533491733151849 64 3938802
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.61216967128414 0.0480074178406099 no 239 0.053462511534878 70 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1984 st072354 53.1 µM 1.61108215461933 0.0481193257193677 no 240 0.0535809086777103 74 5762938
SGTC_70 0141-0289 43.283 µM 1.60392881011516 0.0488606320904917 no 241 0.0543648727517741 95 352408
SGTC_3355 9151058 44.0485 µM 1.60286159022793 0.048972007073597 no 242 0.0544826076847922 81 17015728
SGTC_1994 st072947 40.9 µM 1.5975707334388 0.0495271589776261 no 243 0.0550692720524049 77 5286565 YDL195W SEC31
SGTC_3006 9075424 71.4286 µM 1.59736372433669 0.0495489814363632 no 244 0.0550923268401628 84 7465181
SGTC_1520 flindersine 88 µM 1.59628954982151 0.0496623418765017 no 245 0.0552120810797831 91 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_16 erodoxin 22.806 µM 1.59338896032845 0.0499694827212754 no 246 0.0555364803757281 125 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_987 1497-1013 404 µM 1.59272771190425 0.0500397133255057 no 247 0.0556106439905629 86 1676435
SGTC_2849 9019321 12.99 µM 1.58352861701733 0.0510249270333871 no 248 0.0566505147106359 77 16489627
SGTC_2115 tiliquinol 12.7705 µM 1.58150189244044 0.051244049109144 no 249 0.056881663293255 88 71208 A bioactive hydroxyquinoline.
SGTC_2940 9060638 45.86 µM 1.57638943541007 0.051800116171858 no 250 0.057468040795237 76 4027022
SGTC_500 h-89 112 µM 1.57636108045788 0.0518032135773445 no 251 0.05747130619987 99 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.56869371088795 0.052646188720421 no 252 0.0583596623695368 91 66535 A nucleotide analog.
SGTC_3261 9137475 49.47 µM 1.5674740721353 0.0527812776362776 no 253 0.0585019610171537 32 17027690
SGTC_2104 5389443 200 µM 1.56114780875688 0.0534864017073224 no 254 0.0592444399952487 98 2244536
SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.55703445343481 0.053948865689644 no 255 0.059731152812951 74 140250 A respiratory chain inhibitor.
SGTC_1297 1068-0111 14.1 µM 1.55629347325986 0.0540325094972339 no 256 0.059819161367667 97 767057
SGTC_2727 riluzole 51.77 µM 1.55347819179883 0.0543512422192027 no 257 0.0601544676804634 97 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.55137312175042 0.0545905386695092 no 258 0.0604061463215561 98 676296 Flavone; oxidizing agent.
SGTC_2498 4'-Methoxychalcone 54.63 µM 1.55130000570863 0.0545988651734274 no 259 0.0604149027375901 73 641818 YHR062C RPP1
SGTC_2499 avocadenofuran 51.48 µM 1.55116558607934 0.0546141755912906 no 260 0.0604310034954518 86 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1703 st026983 48.3 µM 1.55021074395558 0.0547230299943827 no 261 0.0605454709610046 66 1104023
SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.54613940662444 0.0551890988020751 no 262 0.0610354517610303 131 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1482 3346-2049 8.48 µM 1.54452622126897 0.0553746342368164 no 263 0.0612304520127428 90 3826804
SGTC_1227 3909-8010 46.6 µM 1.54344818606542 0.0554988953641644 no 264 0.0613610349681663 73 15982272
SGTC_904 1141-0088 396 µM 1.54213599133845 0.0556504441288285 no 265 0.0615202752439137 84 1378119
SGTC_2516 gossypol 71.55 µM 1.54152442663372 0.0557211868127342 no 266 0.0615946013354108 97 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_19 0279-0214 38.434 µM 1.54128946252162 0.0557483851250535 no 267 0.0616231761743599 94 3566274 YBR002C RER2
SGTC_2928 9011484 9.79 µM 1.54081708855474 0.0558030965578045 no 268 0.0616806546105771 121 2994751
SGTC_1886 st057356 49.9 µM 1.53865813729457 0.0560536907202324 no 269 0.0619438886788391 83 24207747
SGTC_2350 9023895 38.85 µM 1.53656315498477 0.0562977075151179 no 270 0.062200160544195 96 2997209
SGTC_172 1112-0046 2.638 µM 1.535901835814 0.0563749094968463 no 271 0.0622812289192763 84 2802135 YIL048W NEO1
SGTC_1066 ketoconazole 628 nM 1.53481920544449 0.0565014751789406 no 272 0.0624141219408233 95 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2732 terfenadine 20 µM 1.52958403995734 0.0571166581079659 no 273 0.0630598612227193 87 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_790 1575-0012 79.1 µM 1.52311654382815 0.0578839182007105 no 274 0.0638647752659461 99 378741 YLR208W SEC13
SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.52143132247739 0.0580851662381251 no 275 0.0640758167790084 95 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_120 rhodamine 6G 52.259 µM 1.50538268800792 0.0600293392319593 no 276 0.0661128586637404 153 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1219 1469-0211 33.1 µM 1.50458995250428 0.0601266782115946 no 277 0.0662147655192617 96 6822282
SGTC_1386 3228-0095 33.8 µM 1.50193200298789 0.0604539464236639 no 278 0.0665573352738629 82 870181
SGTC_298 1391-0729 10 µM 1.50055566800832 0.0606239587828894 no 279 0.0667352624728653 89 3237558
SGTC_940 3232-1287 54.8 µM 1.50004934905701 0.060686596062681 no 280 0.0668008099342063 92 1585493 YIL048W NEO1
SGTC_3306 9127676 59.7925 µM 1.49832922797516 0.0608997723072892 no 281 0.0670238669294715 80 41905287
SGTC_318 1488-0629 67.2 µM 1.49487054748143 0.0613301816310995 no 282 0.0674741150941895 87 3662576
SGTC_932 2857-0803 154 µM 1.48656751848811 0.0623731372802067 no 283 0.0685645359709864 100 674898
SGTC_2151 5563267 85.4165 µM 1.48315985071422 0.062805161577891 no 284 0.0690159727631387 114 5310824
SGTC_1935 st074532 41.6 µM 1.48167918883663 0.0629936051230713 no 285 0.0692128385558419 107 2829742
SGTC_2986 9022445 71.43 µM 1.48088737987966 0.0630945590760132 no 286 0.0693182932646665 103 6459286
SGTC_527 4476-4215 268 µM 1.47983299297191 0.0632291867133624 no 287 0.0694589107210609 77 4418754
SGTC_1423 4048-0112 5.59 µM 1.47547335269873 0.0637882157188896 no 288 0.0700426636236053 100 X1423
SGTC_1413 3910-0535 34.4 µM 1.47179988107776 0.064262236629255 no 289 0.0705374628741854 109 2876951
SGTC_225 nsc-122657 1.016 µM 1.47090212078684 0.0643784979373396 no 290 0.070658794525732 86 275685
SGTC_2553 4-methylesculetin 85.09 µM 1.46985429238289 0.0645143999227655 no 291 0.0708006105479729 85 5319502
SGTC_1017 4239-0030 168 µM 1.46834020948456 0.0647111680719491 no 292 0.0710059169275768 99 1149593
SGTC_194 1486-1323 56.904 µM 1.46564269416311 0.0650628879503785 no 293 0.0713728267980002 121 5178754
SGTC_1546 5-methoxyflavanone 78.7 µM 1.46290991251221 0.0654207171506346 no 294 0.0717460156382745 83 147795
SGTC_2442 5158906 48.48 µM 1.4607247545671 0.0657079374463007 no 295 0.072045496383477 96 1893835
SGTC_2766 oltipraz 83.91 µM 1.45974325400783 0.0658372650179842 no 296 0.0721803247246052 111 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_739 1486-1183 203 µM 1.44937484297917 0.0672155376069362 no 297 0.0736164651204543 88 4346692
SGTC_2380 9035439 200 µM 1.44827563921076 0.0673629530164836 no 298 0.0737699889171424 94 6462575
SGTC_884 0851-0618 334 µM 1.44806498752856 0.0673912322557346 no 299 0.0737994381780916 106 9642473
SGTC_1125 tnp00248 1.32998 µM 1.44793940329429 0.0674080958579776 no 300 0.0738169992215945 122 24207736
SGTC_2141 5621638 7.665 µM 1.44591397310741 0.0676805237692643 no 301 0.0741006661118618 93 2856238
SGTC_1512 0259-0544 12.2 µM 1.44408192361457 0.0679276731758495 no 302 0.0743579660925373 115 18476
SGTC_1333 1482-0047 286 µM 1.44312093484434 0.0680575920326178 no 303 0.0744932034838936 97 3811116
SGTC_1163 k060-0048 49.9 µM 1.44260683509518 0.0681271733872509 no 304 0.0745656284223998 104 6809982
SGTC_2130 NSC 7 2.4545 µM 1.44236340849428 0.0681601393597973 no 305 0.0745999404265982 99 21448
SGTC_2294 7971431 200 µM 1.44180351604222 0.0682360093513229 no 306 0.0746789053574159 105 5741572
SGTC_2227 7312221 64.1025 µM 1.43868001121216 0.0686604663423039 no 307 0.075120602623016 104 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2909 7941780 10.49 µM 1.43523475666346 0.0691310048108697 no 308 0.0756101062159004 112 1243215
SGTC_2892 9047358 58.44 µM 1.43512536649204 0.0691459854622255 no 309 0.0756256881412 91 6466771
SGTC_2228 7354201 200 µM 1.43267648715914 0.0694820072442643 no 310 0.0759751559952433 125 753451
SGTC_698 k064-0052 127 µM 1.43092289348236 0.0697233973832147 no 311 0.0762261574953487 111 5088751
SGTC_2344 7990960 76.95 µM 1.4297519539532 0.0698849416299111 no 312 0.0763941115865875 137 140813
SGTC_160 3453-0671 289.699 µM 1.42949614903573 0.0699202710937858 no 313 0.0764308404941937 100 5322268
SGTC_1803 st050068 52.4 µM 1.42817743116222 0.0701026185787256 no 314 0.0766203974412416 110 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1738 st035555 74 µM 1.42791760061773 0.0701385900980983 no 315 0.0766577884879328 117 5331140
SGTC_1552 6-methylflavone 10.6 µM 1.42422542376507 0.0706512788715907 no 316 0.0771906137708649 95 689013
SGTC_1878 temozolomide 1 mM 1.42050375558054 0.0711709725469883 no 317 0.0777305380077922 99 5394 DNA alkylating agent.
SGTC_496 calpeptin 138 µM 1.41918699581916 0.0713555461639361 no 318 0.0779222530982948 95 73364 A calpain inhibitor.
SGTC_993 3909-8757 62.7 µM 1.417112678333 0.0716470535980852 no 319 0.0782249931808724 84 4288324 YLR208W SEC13
SGTC_1932 st074806 40.9 µM 1.4153088233742 0.0719012944132566 no 320 0.0784889845619918 135 17251235
SGTC_2894 9048625 32.47 µM 1.4126685586744 0.0722746679900499 no 321 0.0788766001919157 121 4092861
SGTC_2359 9039622 200 µM 1.41135718922233 0.0724606669750695 no 322 0.0790696597270108 99 6463596
SGTC_90 0870-0863 4.608 µM 1.4107983892631 0.0725400360835865 no 323 0.0791520347910687 117 1738164
SGTC_3056 9094900 49.47 µM 1.40564065212661 0.0732757618019461 no 324 0.079915429088319 101 25236784
SGTC_2900 5328528 85.29 µM 1.4052180775686 0.0733362920662257 no 325 0.0799782200740684 105 795359
SGTC_319 1348-1596 45.5 µM 1.40364739119311 0.0735616150509983 no 326 0.0802119377558148 120 5380505
SGTC_3124 9127567 49.47 µM 1.40356490813787 0.0735734622792851 no 327 0.0802242254616457 89 17592030
SGTC_2471 5466956 24.79 µM 1.40351315162558 0.0735808969294014 no 328 0.0802319364843732 132 724419
SGTC_2980 9014342 25.29 µM 1.39736501621076 0.0744681493763576 no 329 0.0811519168214539 142 2996599
SGTC_960 1222-0186 7.7 µM 1.39708584976988 0.0745086295734994 no 330 0.0811938782228288 109 3126296
SGTC_840 0245-0196 390 µM 1.39440787879855 0.0748977994019098 no 331 0.0815972351244676 112 3827528
SGTC_2332 7982454 138.89 µM 1.39270227414611 0.0751464694788392 no 332 0.081854920319887 123 2981748
SGTC_1572 epiandrosterone 68.9 µM 1.39110028178139 0.075380606183826 no 333 0.0820975097302035 102 441302 A steroid.
SGTC_215 1287-0124 461.5 µM 1.38892243382994 0.0756997973984163 no 334 0.0824281689685079 86 5560863
SGTC_2733 amorolfine 100 µM 1.38454365535361 0.0763446776026713 no 335 0.083096025257075 117 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_597 k018-0003 82.8 µM 1.38411472832971 0.0764080715159007 no 336 0.0831616639015514 112 6786234
SGTC_2693 st077581 40.7 µM 1.38266610634338 0.0766224688372529 no 337 0.0833836345263943 109 25238761
SGTC_3091 9116372 49.47 µM 1.38256257077358 0.0766378096936658 no 338 0.0833995161943595 98 17169793
SGTC_1634 st006576 41 µM 1.38002343375234 0.0770147649209797 no 339 0.0837897148873208 112 3915356
SGTC_1412 3909-8563 178 µM 1.37655627356403 0.0775317663265012 no 340 0.084324738887171 123 23767530
SGTC_401 neomycin 50 µM 1.37523167597483 0.0777299763551058 no 341 0.0845298154534011 99 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_680 0417-1641 114 µM 1.36901433563276 0.0786654691083771 no 342 0.0854973969093516 117 2835990
SGTC_1059 3448-6867 171 µM 1.36249507043933 0.0796555291756192 no 343 0.0865208494075045 132 3934407
SGTC_2402 5553605 200 µM 1.3616510128696 0.0797843997553707 no 344 0.0866540239622773 105 6758546
SGTC_223 busulfan 5 mM 1.35379652720978 0.0809911927721684 no 345 0.0879006509661487 98 2478 A DNA alkylator.
SGTC_519 k048-0011 62.8 µM 1.35158135572872 0.0813340184252067 no 346 0.0882546389780336 115 6836379
SGTC_3334 9142812 21.919 µM 1.34890949086236 0.0817489782098431 no 347 0.088683019692294 116 45283678
SGTC_1350 1495-0454 146 µM 1.34633032978847 0.0821510522682215 no 348 0.0890980043049107 115 1069057
SGTC_2267 7931562 200 µM 1.34223094294588 0.0827931822365183 no 349 0.0897605632371257 108 934880
SGTC_2805 7950783 58.44 µM 1.34116903018148 0.082960135017338 no 350 0.0899327895067078 122 1178958 YDL195W SEC31
SGTC_2017 5132927 60.65 µM 1.34093088673811 0.0829976104129346 no 351 0.0899714464795431 100 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1772 st048439 82.2 µM 1.33836945203206 0.0834014954290415 no 352 0.0903880159353775 124 2927068 YDL195W SEC31
SGTC_1889 st059080 5.18 µM 1.33539328961155 0.0838726277337239 no 353 0.0908738299325428 98 176925 Isolated from Daphnopsis sellowiana.
SGTC_1983 st071813 46.9 µM 1.33501946253549 0.0839319463049648 no 354 0.090934988304727 121 11838595
SGTC_748 act1.228 77.9 µM 1.33408743476912 0.0840799768830768 no 355 0.0910876016622438 108 4421505 YNR035C ARC35
SGTC_3255 9139072 49.47 µM 1.33219551215545 0.0843810666927488 no 356 0.091397975449197 109 17646060
SGTC_1104 tacrolimus 29.8 µM 1.33164434176771 0.0844689346407356 no 357 0.09148854337456 129 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1238 0333-0287 48.8 µM 1.33065496525195 0.0846268338802426 no 358 0.0916512838506831 118 7226
SGTC_2480 5767542 37.17 µM 1.3301397367227 0.0847091492312763 no 359 0.0917361176014481 120 2867358
SGTC_1069 diphenylcyclopropenone 8.49 µM 1.32964959513671 0.0847875122901782 no 360 0.0918168746998074 140 65057 A dermal irritant. YDR527W RBA50
SGTC_2724 maprotiline 69.64 µM 1.3279162642933 0.0850650705035047 no 361 0.0921028855377199 118 4011 A tricyclic antidepressant.
SGTC_2110 5483698 200 µM 1.32702348489257 0.0852082966759159 no 362 0.0922504570484549 110 2848765 YHR062C RPP1
SGTC_580 1123-0028 41 µM 1.32392993538139 0.0857059843225057 no 363 0.0927631575893569 135 1677248 YPR107C YTH1
SGTC_1025 k007-0731 70 µM 1.32069522052504 0.0862287066365657 no 364 0.0933015041814426 108 6256118
SGTC_2948 9070189 9.45 µM 1.31920401132019 0.086470484031103 no 365 0.0935504588081928 104 6473636 YDL196W YDL196W
SGTC_2874 9043904 71.43 µM 1.31873278946589 0.0865469909356897 no 366 0.0936292303403371 130 4463428
SGTC_704 1310-0270 142 µM 1.31420750359324 0.0872842878638522 no 367 0.0943881920284875 114 5718033
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.30922662101997 0.0881012245166855 no 368 0.0952287986198353 133 688664
SGTC_2659 sanguinarine 24.21 µM 1.30802594545539 0.088299002622533 no 369 0.0954322546234088 119 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1507 4075-3230 155 µM 1.30794354722165 0.0883125875770721 no 370 0.0954462288324628 103 659771
SGTC_1305 1181-0477 144 µM 1.30788848258496 0.0883216669237181 no 371 0.0954555682792828 131 6252086
SGTC_1967 st070177 51.4 µM 1.30183589271578 0.089323895524458 no 372 0.0964862455524964 124 5729214
SGTC_119 0121-0043 24.815 µM 1.3005549823947 0.0895370778186569 no 373 0.09670541233925 153 1092378
SGTC_1990 st072050 59.8 µM 1.30051623774123 0.0895435319934929 no 374 0.0967120473335029 116 17233948
SGTC_3273 9137859 49.47 µM 1.30043706438876 0.0895567219512605 no 375 0.0967256067532559 141 2377234
SGTC_429 1112-0049 25.5 µM 1.29710695672733 0.0901128135682192 no 376 0.0972971941116592 120 2836170
SGTC_2570 licareol 100 µM 1.29585778822239 0.09032207135929 no 377 0.0975122421963621 123 443158
SGTC_2157 5649910 96.377 µM 1.29221931946475 0.0909336353292984 no 378 0.0981406015051464 116 2858091
SGTC_560 2332-1943 155 µM 1.28794753084197 0.0916555636976618 no 379 0.0988821141760991 122 21177716
SGTC_3257 9139206 32.98 µM 1.28462275875382 0.0922203793863361 no 380 0.0994620708712516 121 4910041
SGTC_1405 3909-7894 12 µM 1.28261129622296 0.0925633372218065 no 381 0.0998141453016018 119 7104060
SGTC_2206 7254556 146.969 µM 1.28259616317481 0.0925659210037318 no 382 0.0998167975461339 107 4398905
SGTC_132 0417-1715 25.805 µM 1.28151808093955 0.0927501276094794 no 383 0.100005876618419 123 6769098
SGTC_2274 7947094 46.08 µM 1.28011447669641 0.0929903606030973 no 384 0.10025243899638 132 2971028
SGTC_131 0141-0277 33.849 µM 1.27380080740802 0.0940766621009203 no 385 0.101367009481618 151 1547771
SGTC_742 0kpi-0133 140 µM 1.27301818645204 0.0942119658953167 no 386 0.101505794221112 135 2728852
SGTC_143 4032-1194 15.74 µM 1.27017606612318 0.094704534414699 no 387 0.102010960528143 153 1806963
SGTC_2537 larixol 68.93 µM 1.26988792325389 0.0947545782929398 no 388 0.102062277794218 140 6708759
SGTC_2904 7225135 42.03 µM 1.26722431566904 0.0952181095040286 no 389 0.102537546837506 164 4446116
SGTC_1614 st002383 48.6 µM 1.26284758114523 0.0959833880538094 no 390 0.103321980613748 103 1947235
SGTC_337 1315-0038 354 µM 1.26148556625246 0.0962224586936765 no 391 0.103566978529627 101 1626437
SGTC_2828 7998861 71.43 µM 1.25661010810658 0.0970818217671896 no 392 0.104447426359749 93 2988188
SGTC_2425 5628681 7.85 µM 1.25575924683456 0.0972323727079655 no 393 0.104601635634977 127 5714958
SGTC_1478 0453-0656 35.7 µM 1.25550425935032 0.0972775234029038 no 394 0.104647881422593 144 5258496
SGTC_2034 5197015 53.07 µM 1.25086040302193 0.0981025051806677 no 395 0.105492706339611 135 780676
SGTC_2869 9037858 32.47 µM 1.24994189057116 0.0982662844886989 no 396 0.10566038768636 124 27187042
SGTC_1361 1608-0041 5.61 µM 1.24776311290524 0.0986555815817866 no 397 0.106058910436788 130 X1361
SGTC_2842 9000675 19.48 µM 1.24735943894866 0.0987278325462506 no 398 0.106132866000018 134 2989072
SGTC_1724 st037281 8.293 µM 1.24681126029859 0.0988260094516447 no 399 0.106233355352529 138 574124 YDL195W SEC31
SGTC_1629 st005085 44.9 µM 1.24576981062988 0.0990127262450156 no 400 0.106424457937159 151 24207091
SGTC_1251 0490-5699 265 µM 1.24524028274861 0.0991077618012013 no 401 0.106521719695354 134 3883818
SGTC_692 k241-0027 77.8 µM 1.2379272974577 0.100427068781021 no 402 0.107871509789433 131 3600480
SGTC_2046 4110841 106 µM 1.23761200017291 0.100484237123232 no 403 0.107929981354698 153 44119630 YMR134W ERG29
SGTC_1316 1272-0050 65.9 µM 1.23697152099408 0.100600439140041 no 404 0.108048827842115 141 7340392
SGTC_986 1493-0483 84 µM 1.23663825634896 0.100660942040779 no 405 0.108110705254448 133 40079
SGTC_985 1493-0307 8.71 µM 1.23633982199626 0.100715144158498 no 406 0.108166137356286 132 3278274
SGTC_254 nsc-64875 3.808 µM 1.23202814547549 0.101500614229707 no 407 0.108969285279837 117 56993
SGTC_1799 st045822 46.1415 µM 1.22789056280322 0.102258555140901 no 408 0.109744026316185 145 3674992
SGTC_1222 0366-0074 1.18 µM 1.22712618180095 0.102399027219507 no 409 0.109887584359439 150 286520
SGTC_2534 helenine 20.12 µM 1.22665410422816 0.102485852076973 no 410 0.109976312321366 141 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1526 st051518 75 µM 1.22408955371474 0.102958461430129 no 411 0.110459223165273 124 673993
SGTC_330 1488-0319 80.1 µM 1.22208820953795 0.103328378452888 no 412 0.110837135657046 152 6846614
SGTC_2061 5245884 80.95 µM 1.21899569853932 0.103901876400532 no 413 0.111422912552128 147 573863
SGTC_2038 4100038 30.985 µM 1.21722420645414 0.104231433065697 no 414 0.111759461317613 162 3596803
SGTC_2793 7325131 81.82 µM 1.21480692998724 0.104682348562227 no 415 0.112219868561557 134 4176441
SGTC_2003 4023581 200 µM 1.212827555926 0.105052629111563 no 416 0.112597878821304 119 16641307
SGTC_1486 3970-0793 4.53 µM 1.21149319577716 0.105302781590612 no 417 0.112853220427273 156 2844330
SGTC_482 fipronil 114 µM 1.20714199885302 0.1061214937282 no 418 0.113688731455273 109 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1737 st035557 69.7 µM 1.20107180161269 0.107271317389767 no 419 0.114861675121013 146 5716916
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.19922604580617 0.107622716902029 no 420 0.115220031131003 139 16623 A steroid.
SGTC_2129 girgensonine 121.053 µM 1.19779549452622 0.107895638735732 no 421 0.115498320823462 172 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_919 tnp00227 403.569 nM 1.19765559416569 0.107922355781827 no 422 0.115525561700734 138 1269246 A methoxyflavone. YNL221C POP1
SGTC_1458 k015-0034 6.33 µM 1.19656030280799 0.108131690392963 no 423 0.115738990536514 126 3598957
SGTC_3114 9122766 49.47 µM 1.19469162773876 0.108489510356462 no 424 0.116103767367442 122 17176985
SGTC_78 0336-0123 156.75 µM 1.19350083694594 0.10871797075783 no 425 0.116336642286908 130 6765896
SGTC_2234 tolnaftate 200 µM 1.19304597637159 0.108805329760301 no 426 0.116425683711021 132 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1182 1222-0449 220 µM 1.19118180178793 0.109163884204504 no 427 0.116791111034163 131 658318
SGTC_393 acivicin 6.25 µM 1.18871560152697 0.109639535497923 no 428 0.117275799577118 148 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1444 4112-3581 28 µM 1.18817380227022 0.109744230336293 no 429 0.117382471355141 146 2877249
SGTC_3180 9109287 49.47 µM 1.18337429951377 0.11067479920724 no 430 0.118330419125112 155 18891271
SGTC_1828 st055811 49 µM 1.18084283408165 0.111167893243796 no 431 0.118832582179892 128 5877589
SGTC_1379 2144-0755 36.5 µM 1.18045668014819 0.111243248689915 no 432 0.118909315084936 156 5392327
SGTC_1682 st012968 530 nM 1.18034034545813 0.111265957819867 no 433 0.118932438886051 121 24207270
SGTC_2375 9072683 200 µM 1.1784938114358 0.111626855250656 no 434 0.119299899029406 155 16798029
SGTC_2617 dihydrotanshinone i 20.83 µM 1.17751725812727 0.11181805677965 no 435 0.119494556665364 158 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_244 nsc-207895 1.295 µM 1.17589801408843 0.112135608127302 no 436 0.119817816278105 96 42640
SGTC_1409 3909-8004 61.9 µM 1.17486203732645 0.112339112268032 no 437 0.120024957827588 138 2119279
SGTC_955 1216-0110 33 µM 1.17295316834237 0.112714775542215 no 438 0.120407293208876 136 3619719
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.17254054295502 0.11279609752922 no 439 0.120490052311083 149 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1170 0310-0127 64.8 µM 1.17059807953272 0.113179489349714 no 440 0.120880184821491 169 774975
SGTC_2797 7859098 81.82 µM 1.16890606023129 0.113514206927776 no 441 0.121220740797553 153 972681
SGTC_2265 7929201 200 µM 1.16838204352532 0.113618011639473 no 442 0.121326347366621 191 1265108
SGTC_677 0929-0063 136 µM 1.16812867380779 0.113668226995564 no 443 0.121377432878511 145 1539583
SGTC_1511 0906-3109 28.5 µM 1.16670147205277 0.113951379738405 no 444 0.121665474074881 158 2882180
SGTC_2876 9059903 25.97 µM 1.16284977463316 0.114718052802649 no 445 0.122445229083829 138 6916095
SGTC_1298 1079-1278 263 µM 1.16127326738062 0.115032909784696 no 446 0.12276539363728 145 2840950
SGTC_1283 0922-0125 16.4 µM 1.15765578285806 0.115757708473204 no 447 0.123502267584114 137 3360884
SGTC_1907 st060210 83.7 µM 1.15697478886693 0.115894514300668 no 448 0.123641330382829 163 688793
SGTC_2321 7390090 138.78 µM 1.15420496100731 0.116452131811958 no 449 0.124208074578092 130 649046
SGTC_982 1491-0518 27.5 µM 1.15392799376227 0.116507994921221 no 450 0.124264845599042 131 3091256
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.15381329568484 0.116531134597625 no 451 0.124288361010122 151 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3225 9130819 49.47 µM 1.15373240428357 0.116547455931741 no 452 0.124304947244588 155 4547121
SGTC_162 k030-0015 37.8 µM 1.15322607581364 0.116649653885762 no 453 0.124408801642743 162 1809920 YMR134W ERG29
SGTC_815 1582-0027 36.9 µM 1.15294922006348 0.116705561651724 no 454 0.124465613923844 161 3128206
SGTC_1966 st070145 16.1 µM 1.15239457676656 0.116817622498289 no 455 0.124579484262078 166 3748532
SGTC_1693 xanthone 101.9 µM 1.14800458125925 0.117707274422807 no 456 0.125483336300812 179 7020 An insecticide.
SGTC_2566 crystal violet carbinol 226 nM 1.14720064276532 0.117870714212678 no 457 0.125649352997199 189 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_627 1391-0720 175 µM 1.14554718446475 0.118207364996474 no 458 0.125991280673158 179 997839
SGTC_3033 9090887 49.47 µM 1.14528189076349 0.118261443097442 no 459 0.126046202550038 158 19325384
SGTC_3277 9138724 49.47 µM 1.14346437176484 0.118632400955921 no 460 0.126422919549182 118 15943418
SGTC_1809 st050081 57.6 µM 1.14084103090314 0.119169276623508 no 461 0.126968041253301 157 5036894
SGTC_1769 st044406 64.4 µM 1.13869722469835 0.11960928560483 no 462 0.127414730350341 193 670903
SGTC_518 1021-0119 62.6 µM 1.13748847123103 0.1198578827798 no 463 0.127667070691065 170 1097762
SGTC_752 1896-0090 130 µM 1.13639971875329 0.120082111693822 no 464 0.127894656727178 164 772567
SGTC_783 0848-0141 92.7 µM 1.13527955687943 0.120313117759859 no 465 0.128129102455322 171 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1761 st044296 37 µM 1.13490114756408 0.120391226146404 no 466 0.128208369532091 161 1826700
SGTC_92 0063-0024 660.874 µM 1.13264443353575 0.120857781632014 no 467 0.128681800552383 147 3594437
SGTC_3267 9137951 49.47 µM 1.13158640367688 0.121076957434779 no 468 0.128904179445633 161 16643986
SGTC_3137 9097352 49.47 µM 1.1255862547099 0.122325205404414 no 469 0.130170344415144 170 44120435
SGTC_3008 9078912 71.4286 µM 1.12451306431805 0.122549416700507 no 470 0.130397715695371 167 16648731
SGTC_1491 4138-0063 26.5 µM 1.12160318839371 0.123158799250413 no 471 0.131015597696756 147 23883227
SGTC_762 1165-0429 115 µM 1.12106926857911 0.123270842251974 no 472 0.131129189309145 170 5967793
SGTC_121 0557-0495 61.343 µM 1.12001953787528 0.123491336310229 no 473 0.131352718169863 186 3104427
SGTC_2839 9003951 25.97 µM 1.11909226089407 0.123686338847426 no 474 0.131550390563739 141 2990634
SGTC_2935 9038016 29.96 µM 1.11709832939593 0.124106384443386 no 475 0.131976142368973 155 6463195
SGTC_822 1487-0950 154 µM 1.11680755349215 0.124167723163704 no 476 0.132038309250796 156 1958375
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.11674524009815 0.124180870835348 no 477 0.13205163426587 159 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1800 st050079 29.0735 µM 1.11561116940848 0.124420321642056 no 478 0.132294304486895 182 3645560
SGTC_2336 9001819 198.65 µM 1.11231156774088 0.125118844185822 no 479 0.133002105956438 207 2989602
SGTC_3250 9135583 49.47 µM 1.11088069462229 0.125422608431579 no 480 0.133309853141085 152 7699353
SGTC_651 3253-0966 34.4 µM 1.10865283723312 0.125896590802057 no 481 0.133789987494584 162 781462
SGTC_3284 9108171 64.8615 µM 1.10854850371041 0.125918818605562 no 482 0.133812501925116 155 8687505
SGTC_3209 9113616 49.47 µM 1.1081392558322 0.126006033507837 no 483 0.133900839841726 171 16649353
SGTC_2539 epi(13)torulosol 80 µM 1.10235795475047 0.127242589308288 no 484 0.135153041456172 159 6708597
SGTC_2777 climbazole 1.536 µM 1.10160350211899 0.127404578901361 no 485 0.135317042567446 166 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1590 st077108 57.8 µM 1.10139990732223 0.127448317592448 no 486 0.13536132288116 146 5489485
SGTC_2429 5902844 64.44 µM 1.09902620709203 0.127959035180157 no 487 0.135878317479178 172 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1200 1643-0193 18.4 µM 1.09871361156151 0.128026398021895 no 488 0.135946501759805 178 5403974
SGTC_953 1188-0045 9.7 µM 1.09845099056417 0.12808301063034 no 489 0.136003803549063 161 6144426
SGTC_2685 mycophenolic acid 18.85 µM 1.09457745974392 0.128920038899115 no 490 0.1368508974886 148 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2497 7-hydroxyflavone 100 µM 1.09322714152627 0.129212717923601 no 491 0.137147041517619 178 5281894
SGTC_348 k064-0012 10.7 µM 1.09126810357263 0.129638154163012 no 492 0.137577464263168 167 5066323
SGTC_1563 conessine 56.1 µM 1.08956400371874 0.130009014792401 no 493 0.137952623365926 124 441082 An anti-amoebic, histamine inhibitor.
SGTC_695 3505-6186 243 µM 1.0883918606435 0.130264532375209 no 494 0.138211076415123 177 1819379
SGTC_301 4119-0100 24.5 µM 1.08733488543284 0.130495242040718 no 495 0.138444418289268 166 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_126 0417-1624 672.48 µM 1.08662225261058 0.130650950287507 no 496 0.138601893267591 213 41912 YDL195W SEC31
SGTC_266 formosanin C 406 nM 1.08476574859066 0.131057194174996 no 497 0.139012709585662 183 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1874 staurosporine 7.6 µM 1.08412570944997 0.131197450883903 no 498 0.139154532547482 171 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_617 3770-0098 35 µM 1.08174274551901 0.131720559497052 no 499 0.139683426835431 160 5962639
SGTC_1665 st014639 11.4 µM 1.07974187643625 0.132160900729358 no 500 0.140128570214304 176 981133 YIL048W NEO1
SGTC_1292 0kpi-0043 232 µM 1.07962539371639 0.132186566887612 no 501 0.140154514361058 165 3333905
SGTC_1530 rhein 70.4 µM 1.07840345942802 0.132456018732061 no 502 0.140426871924666 165 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2023 5144124 124 µM 1.0765531246109 0.132864760854016 no 503 0.140839977685135 156 2830192
SGTC_449 xestospongin c 11.1929 µM 1.07559482042113 0.133076792920463 no 504 0.141054252447786 152 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_3097 9117246 49.47 µM 1.0714515412749 0.133996204425341 no 505 0.141983224248165 153 16423892
SGTC_1630 st005209 31.3 µM 1.06919125812336 0.134499606826587 no 506 0.142491748507082 174 3367314
SGTC_2963 9082507 9 µM 1.06879654151452 0.134587649722146 no 507 0.14258067904127 169 16459611
SGTC_998 3996-0085 177 µM 1.06807678804232 0.134748295020671 no 508 0.142742937708022 162 715391
SGTC_114 0364-0001 490.298 µM 1.06569354995279 0.135281160461631 no 509 0.143281097163224 185 4003655
SGTC_3286 9117135 37.221 µM 1.06533484958342 0.135361486757628 no 510 0.143362213844432 180 3438150
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.065183829712 0.135395315476468 no 511 0.143396374828069 164 688761
SGTC_1188 1403-0014 4.57 µM 1.06231015436038 0.136040128080322 no 512 0.144047453042679 163 9614867
SGTC_2919 7978188 46.38 µM 1.06076602969981 0.136387474962491 no 513 0.144398121911676 161 2980291
SGTC_678 1218-2179 85.9 µM 1.05809193234406 0.136990440386822 no 514 0.145006766066091 181 6820081 YOR116C RPO31
SGTC_958 1222-0007 33 µM 1.05729199597284 0.137171166439057 no 515 0.145189172529611 191 7312461
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.05446994163829 0.137810040996501 no 516 0.145833907659368 181 91467 include heat shock
SGTC_999 SEC7.066 22.7 µM 1.05309526572492 0.138121983047372 no 517 0.146148666219933 191 740511 YDR170C SEC7
SGTC_1042 0350-0096 82 µM 1.05169651682241 0.13843988160992 no 518 0.146469404798577 173 3122515
SGTC_1666 st014829 29 µM 1.05152902656926 0.138477981108119 no 519 0.146507842620298 160 3858230
SGTC_1035 k081-0041 55.2 µM 1.05098431205212 0.138601938316283 no 520 0.146632897541619 182 731709
SGTC_25 0118-0223 35.662 µM 1.05056455674337 0.138697510911337 no 521 0.146729313328725 174 5333628
SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.04943723100668 0.13895440983792 no 522 0.146988465140496 147 77254
SGTC_275 trichlorophene 5.69 µM 1.04801062560145 0.139279973790271 no 523 0.147316855688463 171 62616
SGTC_2177 5811945 192 µM 1.04788091228368 0.139309601235127 no 524 0.147346738787378 182 5343475
SGTC_1021 4476-0760 85.3 µM 1.04688493341875 0.139537232759322 no 525 0.147576325780959 144 746768
SGTC_2200 6600604 21.907 µM 1.04683721640965 0.139548144854724 no 526 0.147587331227948 202 2904777
SGTC_1712 st032288 53.4 µM 1.04553831745734 0.139845404611025 no 527 0.14788712034263 197 2883011
SGTC_2597 laccaic acid a 100 µM 1.04166268437674 0.140734919969256 no 528 0.148784047654334 159 5491415 A textile dye.
SGTC_1525 8-methoxypsoralen 92.5 µM 1.0362821836885 0.141976177304568 no 529 0.150035257722869 176 4114 Related to psoralen; DNA damaging agent.
SGTC_1706 st031321 9.9705 µM 1.03607538040651 0.142024033346887 no 530 0.150083488446881 175 6103185
SGTC_2364 9055074 200 µM 1.03566516323028 0.142118993408276 no 531 0.150179190004545 152 6470630
SGTC_880 0833-0487 87.2 µM 1.03375580296883 0.142561551456237 no 532 0.150625169112998 188 76075
SGTC_1439 4092-1168 46 µM 1.03359900097375 0.142597936924355 no 533 0.150661833313388 181 2886240
SGTC_339 3091-4833 71.4 µM 1.03031152745459 0.143362232111511 no 534 0.151431894737939 197 3240077
SGTC_1382 3002-2117 298 µM 1.02779629581721 0.143948855482824 no 535 0.152022829535935 179 1497314
SGTC_1342 1486-1464 234 µM 1.02752834776311 0.144011443860978 no 536 0.15208587207217 179 3253938
SGTC_2930 9013230 14.89 µM 1.02531458027868 0.144529246679151 no 537 0.152607389166989 180 2995857
SGTC_272 doxorubicin 8.13 µM 1.02395663854573 0.144847490822454 no 538 0.152927878119196 188 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2060 5238662 140 µM 1.02236777765789 0.145220451263603 no 539 0.153303432632307 171 790130
SGTC_94 0334-0113 514.748 µM 1.01969781375504 0.145848637966334 no 540 0.153935899430494 192 6795178
SGTC_222 nsc-310342 10.666 µM 1.01927493264272 0.145948300336938 no 541 0.154036230590592 166 432556
SGTC_818 4072-2707 53.5 µM 1.01872732441384 0.146077425712892 no 542 0.154166218304526 167 882871
SGTC_479 n-linoleoylglycine 10 µM 1.01812851467005 0.146218712165181 no 543 0.154308442930144 189 6433346 An anti-infammatory.
SGTC_427 1354-0053 47.3 µM 1.01806288911041 0.146234201797649 no 544 0.154324035075527 166 6813657
SGTC_544 k015-0020 52.4 µM 1.01590581699254 0.146743949999491 no 545 0.154837119276643 190 3008304
SGTC_681 1642-0006 26.6 µM 1.01544124395989 0.14685389135539 no 546 0.154947770583953 212 4446530
SGTC_1514 1189-1591 158 µM 1.01409143009905 0.147173638651755 no 547 0.15526956345815 198 767698 YMR146C TIF34
SGTC_1281 0884-0031 11.8 µM 1.01319488085848 0.147386273244583 no 548 0.155483542582666 188 1548255
SGTC_2451 5856223 45.7 µM 1.01058639439235 0.148006098331752 no 549 0.156107215198387 209 2179896
SGTC_2147 5545932 89.7195 µM 1.00978109739635 0.148197803879288 no 550 0.156300089177104 200 797404
SGTC_3235 9132602 49.47 µM 1.00518052297848 0.14929618155553 no 551 0.157404966001631 198 4912240
SGTC_1852 st056254 31.4 µM 1.00302309705797 0.149813129933961 no 552 0.157924858643602 177 442583
SGTC_1155 4088-0394 48.2 µM 1.00214008405264 0.150025055701413 no 553 0.158137970350374 179 2326248
SGTC_51 1013-0126 23.419 µM 1.00075726794294 0.15035733713787 no 554 0.158472086638271 154 1627850
SGTC_1145 3546-0597 10.2 µM 0.996561652204039 0.151368514537546 no 555 0.159488663753427 184 875334
SGTC_2946 9065502 71.43 µM 0.99632574393485 0.151425504320233 no 556 0.159545949651394 139 16489101
SGTC_3313 9133968 57.047 µM 0.996197217165118 0.15145655931011 no 557 0.159577165633336 183 1494643
SGTC_3282 9108498 15.4605 µM 0.994459008133152 0.151876966027018 no 558 0.159999726293083 188 16459645
SGTC_450 aminopyrene 156 nM 0.992174979405597 0.152430563397951 no 559 0.160556087806685 197 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_3349 9149703 23.001 µM 0.991007555286763 0.152714037379091 no 560 0.160840945529653 156 4910494
SGTC_2808 7946468 45.46 µM 0.990317424021997 0.152881779439721 no 561 0.161009496331756 200 2970879
SGTC_3121 9125696 49.47 µM 0.990183195849593 0.1529144188839 no 562 0.161042292272818 187 1235365
SGTC_848 0368-0089 85.6 µM 0.987944651812925 0.153459432978474 no 563 0.161589877814186 183 762535
SGTC_1043 0916-0009 19.3 µM 0.984681244756641 0.154256270860697 no 564 0.162390334063431 200 3101130
SGTC_467 ro 31-8220 72.8 µM 0.979995699496627 0.155405133824185 no 565 0.163544120734976 191 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2362 9071156 126 µM 0.9786345280489 0.155739939189172 no 566 0.163880296248144 176 653133
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.978132030769884 0.155863657834192 no 567 0.164004513836252 223 16725076
SGTC_624 k048-0052 28 µM 0.975038580072581 0.156626715742721 no 568 0.164770561579877 169 6835531
SGTC_1611 st001856 99.4 µM 0.966683288587026 0.158699976640264 no 569 0.166851191869849 208 647478
SGTC_1398 3558-0053 112 µM 0.965433308972358 0.159011683643039 no 570 0.167163912321588 174 4532369
SGTC_1039 k821-0043 94 µM 0.963510920546017 0.159491851353901 no 571 0.167645593235239 176 15992768
SGTC_1710 st031758 61.5 µM 0.961955985068982 0.159880931533558 no 572 0.16803585704227 189 5394341
SGTC_340 k038-0059 454 µM 0.961525300673012 0.159988808256847 no 573 0.168144055216916 206 23733424
SGTC_420 mitomycin C 81.9 mM 0.960433929169996 0.160262385283324 no 574 0.168418434391 190 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_229 benomyl 22.8748 µM 0.959403535942186 0.16052095717236 no 575 0.168677747244082 176 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_368 fentichlor 4.58 µM 0.957476467955211 0.1610052760648 no 576 0.169163409183804 194 7329 A pesticide.
SGTC_1257 0669-0121 16 µM 0.957142634371102 0.161089273352542 no 577 0.169247633468431 196 4307855
SGTC_1569 carminic acid 40.6 µM 0.954933273450744 0.161645900777893 no 578 0.169805720957775 188 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2898 9056270 58.44 µM 0.954910110909021 0.161651742992343 no 579 0.169811578090224 141 19154699
SGTC_1224 0823-0416 294 µM 0.954731726049146 0.161696741051408 no 580 0.169856690768595 186 3598164
SGTC_195 4234-0266 16.654 µM 0.953782984323002 0.161936200854125 no 581 0.170096752119958 217 2303354
SGTC_693 4161-2696 114 µM 0.947657493865404 0.163487815471395 no 582 0.171651923354004 221 805759
SGTC_2006 4011487 200 µM 0.945697563379617 0.163986307002242 no 583 0.172151432827438 194 45595294
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.944011144863543 0.16441602158978 no 584 0.172581976565402 206 1377
SGTC_906 1165-0455 526 µM 0.943723057678009 0.164489501725772 no 585 0.17265559401436 195 3252859
SGTC_667 1498-1044 59 µM 0.943408627274314 0.16456972530916 no 586 0.172735966023982 216 6739982
SGTC_2861 9024595 19.48 µM 0.942071796316402 0.164911086564576 no 587 0.173077941504561 159 16482810
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.939334040679803 0.165611605545645 no 588 0.173779633246415 177 688664
SGTC_1191 1487-1166 10.6 µM 0.93833241592507 0.165868374839012 no 589 0.174036802967892 193 3955771
SGTC_2245 6637752 200 µM 0.937001321661401 0.166210002541178 no 590 0.174378939035705 195 681890
SGTC_386 1509-0011 3.07 µM 0.932852172628822 0.167277803010257 no 591 0.17544814964303 190 3107280
SGTC_409 arachidonic acid 100 µM 0.931486906560083 0.167630124491447 no 592 0.17580087722697 202 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2449 5812982 45.77 µM 0.930263196065962 0.167946321927879 no 593 0.176117414242856 183 776185
SGTC_3207 9114163 49.47 µM 0.928930195537893 0.168291195650685 no 594 0.176462631574207 221 849233
SGTC_355 1311-2252 105 µM 0.925761486444038 0.16911283066525 no 595 0.177284973117732 194 5338538
SGTC_2463 5473429 200 µM 0.925704228252376 0.169127701165995 no 596 0.177299854955432 193 5399405
SGTC_2444 5485484 36.41 µM 0.925652835278089 0.169141049128643 no 597 0.177313213050468 226 6790631
SGTC_3025 9087895 49.47 µM 0.924379184534208 0.169472062240802 no 598 0.177644464185867 204 17173641
SGTC_1311 1190-0148 100 µM 0.92380195072831 0.169622218152188 no 599 0.177794719684626 212 1961333
SGTC_1768 st044301 37.178 µM 0.922935803203768 0.169847689287938 no 600 0.178020330546807 247 3931349
SGTC_3017 9080681 49.47 µM 0.918966359961478 0.170883451660113 no 601 0.17905658400367 204 16451914
SGTC_2565 isoliquiritigenin 100 µM 0.918957717503187 0.170885711170787 no 602 0.179058844315811 206 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_3346 9158254 43.5805 µM 0.917465805704787 0.171276047610657 no 603 0.179449301646666 223 17639500
SGTC_706 4262-0057 46.9 µM 0.91369887145028 0.172264144091025 no 604 0.18043754859711 206 883298
SGTC_771 0250-0039 27.3 µM 0.913332317144113 0.172360487971121 no 605 0.180533895262101 227 3005115
SGTC_2994 9053520 71.4286 µM 0.912801491261132 0.172500069350077 no 606 0.180673476941113 170 4647384
SGTC_460 trequinsin 123 µM 0.911394149738999 0.172870480495728 no 607 0.18104386749287 216 5537 A vasodilator.
SGTC_3314 9135860 59.4275 µM 0.91057734933573 0.173085693982273 no 608 0.181259054769851 198 25252478
SGTC_672 1441-0018 53.7 µM 0.910323907672758 0.173152506374745 no 609 0.181325856899638 193 251141
SGTC_3327 9140648 26.9345 µM 0.909082554618012 0.173479989572766 no 610 0.181653275248726 234 8029710
SGTC_1186 1319-0216 26 µM 0.904622969112305 0.174659728742108 no 611 0.182832581307299 208 4565136
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.902068659432529 0.175337734932141 no 612 0.183510198061474 205 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2624 nerol 100 µM 0.900078874304273 0.175867050564147 no 613 0.184039138802712 221 637566 A natural product oil.
SGTC_322 k048-0136 19.3 µM 0.899342219274465 0.176063269364494 no 614 0.184235202900944 210 6823282
SGTC_18 0111-0177 500 nM 0.897732513557282 0.176492520046612 no 615 0.184664085578866 215 721752
SGTC_1849 st056239 19.2 µM 0.896402203675856 0.176847765043502 no 616 0.185018995394622 218 5393181
SGTC_2055 5235184 200 µM 0.890549758050878 0.178415960274956 no 617 0.186585381534224 214 2836034
SGTC_3226 9131256 49.47 µM 0.890538461658129 0.178418995652414 no 618 0.186588412891636 191 17178073
SGTC_595 3909-8003 73.7 µM 0.888951847077519 0.178845647297799 no 619 0.187014479655107 222 699517
SGTC_2735 sertaconazole 140 nM 0.888346139437793 0.179008695511403 no 620 0.187177293969171 234 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_555 4296-0685 37 µM 0.887381295023304 0.179268611521642 no 621 0.187436825273408 231 2908540 YHR072W ERG7
SGTC_395 anisomycin 6.25 µM 0.886328300199992 0.179552544759791 no 622 0.187720321648524 219 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_858 0438-0351 2.77 µM 0.886213228180546 0.179583590307279 no 623 0.187751318378719 222 2799119
SGTC_158 k038-0087 26.446 µM 0.882060393762397 0.18070625022437 no 624 0.188872074373683 211 X158
SGTC_531 3788-1495 174 µM 0.879737360577046 0.181336164289013 no 625 0.189500802554763 202 2896655
SGTC_1154 4088-0362 150 µM 0.879024541698944 0.181529727716294 no 626 0.189693984679149 216 6618304
SGTC_2616 abietic acid 100 µM 0.878237679716933 0.181743547392249 no 627 0.189907373938666 222 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1434 4073-0095 163 µM 0.876193475912018 0.182299769621752 no 628 0.190462431319281 220 24133745
SGTC_2358 9037157 4 µM 0.874338114730565 0.182805528133791 no 629 0.19096707418883 230 2388925
SGTC_892 0929-0076 29 µM 0.872789943419149 0.18322821849318 no 630 0.191388791031972 210 5751038
SGTC_938 3126-1755 342 µM 0.864307595291287 0.185554920370353 no 631 0.193709469442823 201 1777771
SGTC_800 3448-7362 155 µM 0.864033870923227 0.185630306878538 no 632 0.193784642101402 246 15991913
SGTC_106 0092-0003 11.579 µM 0.862611113417045 0.18602245496676 no 633 0.194175658991356 205 1072148
SGTC_1717 st033143 58.0435 µM 0.860023026740368 0.18673711303809 no 634 0.194888174724831 204 674616
SGTC_709 3807-1509 243 µM 0.859979232049466 0.186749220834605 no 635 0.194900245329048 250 1886677 YPL242C IQG1
SGTC_3205 9113483 49.47 µM 0.859871867691596 0.186778905616197 no 636 0.194929838799809 215 17018033
SGTC_306 1672-3436 11.6 µM 0.857718823801317 0.187374809303611 no 637 0.195523871623132 227 6797378
SGTC_2044 5102272 200 µM 0.857545010512801 0.187422967283948 no 638 0.195571875265101 226 592666
SGTC_1664 st014217 9.02 µM 0.855982403291696 0.187856258143685 no 639 0.196003756406945 217 3982782
SGTC_2770 toltrazuril 17.5 µM 0.854952556544125 0.18814215927895 no 640 0.196288706607964 198 68591 Kills coccidiodes.
SGTC_855 0428-0020 25 µM 0.853198017576762 0.18862986406758 no 641 0.196774751280677 222 6812414
SGTC_366 0181-0206 4.31 µM 0.851808623264198 0.189016622951656 no 642 0.197160159727958 207 274874
SGTC_2162 5663267 200 µM 0.851615048711348 0.189070546092916 no 643 0.1972138922082 214 6456493
SGTC_1378 2093-0007 380 nM 0.849756307892966 0.189588808832087 no 644 0.197730292861187 239 3618014
SGTC_787 4152-0075 138 µM 0.849558395397981 0.189644043149561 no 645 0.197785325566317 217 9566539
SGTC_233 rapamycin 362 pM 0.848132662674538 0.190042235551774 no 646 0.198182046553081 238 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_851 0394-0702 453 µM 0.848124992182974 0.190044379229523 no 647 0.19818418222415 239 762646
SGTC_2640 pentamidine 10.38 µM 0.84652024783831 0.190493185023229 no 648 0.198631291648297 230 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_746 1095-0025 46.6 µM 0.8454069970664 0.19080491468287 no 649 0.198941819583086 235 6749286
SGTC_2111 5486399 200 µM 0.845223916073901 0.190856210513143 no 650 0.198992915827145 216 689674
SGTC_734 2023-0417 80 µM 0.845139786242665 0.190879784937125 no 651 0.199016398351535 239 3935732
SGTC_2446 5162541 200 µM 0.845041315029057 0.190907380297803 no 652 0.199043885998572 228 1549321
SGTC_226 1,3-diallylurea 8.28947 mM 0.844130967697801 0.191162609953191 no 653 0.199298112292458 225 74537 YKL182W FAS1
SGTC_3299 9121982 43.1275 µM 0.844042290464622 0.191187483135237 no 654 0.199322887006357 213 17594604 YPL160W CDC60
SGTC_3215 9129942 49.47 µM 0.843278608796394 0.191401771222942 no 655 0.199536321725414 240 17682944
SGTC_1051 3253-3903 78 µM 0.842953456828564 0.191493053100067 no 656 0.199627237344131 247 5509239
SGTC_1620 st003704 16.5 µM 0.841890449488924 0.191791663662928 no 657 0.199924638334024 221 2834414
SGTC_688 0527-0193 473 µM 0.840862340846333 0.192080741850896 no 658 0.200212528908627 267 4007154
SGTC_1324 1418-0026 34.4 µM 0.840751356428642 0.192111963802284 no 659 0.200243621612783 213 1372513
SGTC_2272 7805186 180 µM 0.839506366320799 0.192462415094428 no 660 0.200592609096853 248 2956062 YPR165W RHO1
SGTC_1302 1159-0335 255 µM 0.838317351405261 0.192797474605396 no 661 0.200926246684552 201 649284
SGTC_3027 9089541 49.47 µM 0.835991786233321 0.193453838612509 no 662 0.201579761946212 225 9943819
SGTC_3196 9111891 49.47 µM 0.834180864640831 0.193965893251235 no 663 0.202089536206976 243 18891510
SGTC_3302 9125395 16.351 µM 0.833763643479737 0.194083983306691 no 664 0.202207093174708 214 17599668
SGTC_1359 1582-0056 520 nM 0.832641042886316 0.194401940984671 no 665 0.202523602153286 227 3661189
SGTC_1278 0874-0585 172 µM 0.83207081546559 0.194563569658317 no 666 0.202684486945287 231 766306
SGTC_2630 antimycin a 100 µM 0.831718942803468 0.194663347341656 no 667 0.202783802904477 240 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1850 st056238 17 µM 0.830474845225767 0.195016375580087 no 668 0.203135182157156 243 5393177
SGTC_2844 9010103 25.97 µM 0.829837089710583 0.195197497488444 no 669 0.20331544878149 238 2480525
SGTC_61 0978-8327 98.565 µM 0.829541509993679 0.195281476480948 no 670 0.203399029083342 222 6150059 YHR072W ERG7
SGTC_1195 1502-0147 41.1 µM 0.829068128149532 0.195416017665832 no 671 0.20353292872369 212 817940
SGTC_1839 st053978 48 µM 0.827122754722416 0.195969508592123 no 672 0.204083744064413 221 3788398
SGTC_1806 st050005 60.3 µM 0.825658685704685 0.196386687015627 no 673 0.204498867314341 216 5194765
SGTC_1332 1480-0653 17.5 µM 0.825536430424606 0.196421547320203 no 674 0.204533554388707 216 5749438
SGTC_59 0330-0160 1.33 µM 0.825224642663892 0.196510468566096 no 675 0.204622032717768 221 4293482
SGTC_3083 9117465 49.47 µM 0.824938707561876 0.196592038124241 no 676 0.204703194660315 242 16420915
SGTC_1862 st057513 3.81 µM 0.822911364658472 0.197170972389716 no 677 0.20527919973986 234 5393163
SGTC_1006 4099-6547 255 µM 0.822478039911118 0.197294847608565 no 678 0.20540243997953 243 3146833
SGTC_2608 thymoquinone 42.66 µM 0.820793940028663 0.197776730701393 no 679 0.205881825483679 236 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1915 st067105 30.6 µM 0.820029433742348 0.19799571864587 no 680 0.206099664000323 239 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2885 9057732 51.95 µM 0.819009797227862 0.198288014810305 no 681 0.206390411949237 256 6471414
SGTC_2281 7943571 200 µM 0.818426240109415 0.198455418509926 no 682 0.206556921755037 239 1244024
SGTC_347 4534-1311 26.2 µM 0.816089550486985 0.199126593174411 no 683 0.207224459992346 237 2862016
SGTC_3014 9081533 49.47 µM 0.814730109231293 0.199517698155629 no 684 0.207613407307795 257 21367265
SGTC_147 4466-0538 29.23 µM 0.813130495586159 0.199978491244255 no 685 0.208071621878549 251 6742687 YHR072W ERG7
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.812534792800844 0.200150255897284 no 686 0.208242415317737 202 6857784
SGTC_3152 9099253 49.47 µM 0.808455941855136 0.20132873016934 no 687 0.209414079570689 246 25236131
SGTC_177 1327-0068 8.361 µM 0.808391579466301 0.20134735922295 no 688 0.20943259892597 244 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1288 0973-0013 65.5 µM 0.807920765356069 0.201483663107551 no 689 0.209568098244334 214 4315430
SGTC_414 piperonyl butoxide 100 µM 0.805560855358006 0.202167705829035 no 690 0.21024805199294 224 5794 A potent inhibitor of cytochrome P450.
SGTC_1548 st061468 90.8 µM 0.804639669480229 0.202435097058073 no 691 0.2105138216747 234 390799
SGTC_2588 indole-3-carbinol 100 µM 0.803977028623166 0.202627571518253 no 692 0.210705120866155 230 3712 Induces cell cycle arrest.
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.803067329562855 0.20289198599581 no 693 0.210967909845521 242 5282362
SGTC_2333 9017922 200 µM 0.802214173007965 0.203140152930688 no 694 0.211214539647099 239 3163164
SGTC_1038 k292-0204 154 µM 0.801617163775113 0.203313919225177 no 695 0.211387223014373 238 4454212
SGTC_63 0099-0242 26.702 µM 0.801596023844861 0.203320073866741 no 696 0.211393339199655 254 3898502 YLR359W ADE13
SGTC_2133 5320837 200 µM 0.801585612886114 0.203323104935547 no 697 0.211396351326806 213 2841355
SGTC_2868 9035608 32.47 µM 0.801470901027273 0.203356504176907 no 698 0.211429541740899 231 6462614
SGTC_599 1935-0052 86.5 µM 0.80046114061235 0.20365064491313 no 699 0.211721834686308 217 9557311
SGTC_547 1120-0019 610 nM 0.799237317654777 0.204007481400685 no 700 0.212076408612147 223 3676939
SGTC_991 3996-0057 64.7 µM 0.796953964984377 0.204674245592243 no 701 0.212738883845089 229 715343
SGTC_2623 humulene 100 µM 0.796574219529246 0.204785261054348 no 702 0.212849177470191 224 6187145 An anti-inflammatory.
SGTC_2240 6690706 185.951 µM 0.793372831451666 0.205722583251803 no 703 0.213780317454911 223 805876
SGTC_1212 0520-0165 585 µM 0.792604822540002 0.205947823738992 no 704 0.214004049062848 251 5403258
SGTC_1153 4055-0057 267 µM 0.792578236676297 0.205955623419292 no 705 0.214011796332166 263 882706
SGTC_965 1291-5240 308 µM 0.792075831068437 0.206103050595056 no 706 0.214158230824304 245 2834598
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.791582001066587 0.206248022286698 no 707 0.214302222613575 221 5379071
SGTC_551 k048-0028 34.9 µM 0.790872665048303 0.206456364946499 no 708 0.214509150521069 245 6836383
SGTC_3238 9133470 49.47 µM 0.787887252025971 0.207334591396912 no 709 0.215381329234549 210 3534688
SGTC_1113 artemisinin 1.17947 µM 0.787685473255306 0.207394028748638 no 710 0.215440352381731 259 2240 An anti-malaria and mitochondrial poison.
SGTC_1976 st070609 63.5 µM 0.787249106732704 0.207522602334964 no 711 0.215568027849433 232 682556
SGTC_1887 st057648 70.8 µM 0.786823090212854 0.207648171769921 no 712 0.215692717353326 258 688672
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.786519851590999 0.207737579455346 no 713 0.215781496828709 241 2724278 An inhibitor of dopamine biosynthesis.
SGTC_782 0083-0095 30.5 µM 0.786309450854481 0.207799627931366 no 714 0.215843108507645 240 3591729 An indicator and reagent.
SGTC_260 nsc-65238 3.989 µM 0.786104338146712 0.207860127470641 no 715 0.215903181505143 223 3246252
SGTC_2487 5918373 44.05 µM 0.783729842693289 0.208561259693292 no 716 0.216599323886567 256 2876279
SGTC_1603 st002045 67.8 µM 0.783573056836179 0.208607603861728 no 717 0.216645335212214 247 5887985
SGTC_538 2922-0838 53.3 µM 0.783420925002607 0.208652578154914 no 718 0.216689986143746 226 777039
SGTC_2974 9094440 9.66 µM 0.781691699437132 0.209164185671139 no 719 0.217197890505128 231 25236134
SGTC_1933 st074711 15.9 µM 0.779922307782024 0.209688440412368 no 720 0.217718303489065 256 17250958
SGTC_2761 levamisole 97.89 µM 0.778221327434772 0.210193153202549 no 721 0.218219272883166 232 26879 An alkaline phosphatase inhibitor.
SGTC_3159 9100096 49.47 µM 0.775056203341357 0.211134201713393 no 722 0.219153224800972 233 25236875
SGTC_134 0269-0018 6.916 µM 0.773943254286118 0.211465687393483 no 723 0.219482174585642 243 4378915
SGTC_261 5-fluorouridine 15.376 µM 0.773270886841003 0.211666095881921 no 724 0.219681040836761 226 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3300 9124615 50.48 µM 0.771928339178111 0.212066593360605 no 725 0.220078435811365 224 24824903
SGTC_1131 3454-3128 32.3 µM 0.77096329972017 0.212354749322249 no 726 0.220364342677377 238 710982
SGTC_440 fluspirilene 35.1 µM 0.768245291137009 0.213167561788536 no 727 0.221170735267248 250 3396 An atypical antipsychotic.
SGTC_398 bronopol 33.3 µM 0.767739151351491 0.213319121562948 no 728 0.221321085630214 252 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1479 0549-0158 134 µM 0.767074756687536 0.213518164909281 no 729 0.221518534781437 231 5440202
SGTC_1441 4106-0040 13 µM 0.76607066054914 0.213819183358869 no 730 0.221817129632605 239 2904180
SGTC_671 0560-0003 407 µM 0.76450320733446 0.214289584564456 no 731 0.22228371304253 225 3238678
SGTC_60 0986-0278 202 µM 0.763366534801343 0.214631082383698 no 732 0.222622416051431 253 3110598
SGTC_2871 9038510 12.99 µM 0.763152559922523 0.214695403587216 no 733 0.222686208671905 272 4945164
SGTC_1722 st034304 3.6505 µM 0.762258071201819 0.21496440964237 no 734 0.222952996594909 246 4036148 YLR033W RSC58
SGTC_2680 butyl paraben 22.24 µM 0.756964137043943 0.216560495183938 no 735 0.224535674239979 286 7184 An antifungal and steroid mimetic.
SGTC_1635 st007035 42.4 µM 0.755627536411289 0.216964552659979 no 736 0.224936270692195 245 3716403
SGTC_2406 ethylparaben 405.7 µM 0.7549507613739 0.217169309384283 no 737 0.225139263293926 236 8434 A possible steroid mimic.
SGTC_1068 loratadine 26.9 µM 0.753211698468611 0.217695970527602 no 738 0.225661355310199 259 3957 A H1 histamine antagonist.
SGTC_1445 4239-0156 97.7 µM 0.753078727733433 0.217736269943474 no 739 0.225701303233093 262 4008346
SGTC_2485 5633444 17.78 µM 0.752646704422233 0.217867232870886 no 740 0.225831122064859 248 5724239
SGTC_2790 5423970 71.43 µM 0.752619430714192 0.217875502107867 no 741 0.225839318967551 245 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1985 st071382 65.5 µM 0.75261093580727 0.21787807775349 no 742 0.225841872080701 263 6123237
SGTC_1888 azatryptophan 97.5 µM 0.752384873937521 0.217946625893157 no 743 0.22590982014406 213 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2857 9024691 58.44 µM 0.75182018318533 0.21811790988647 no 744 0.226079601351714 250 16478292
SGTC_1871 st057448 67.3 µM 0.751797008462078 0.218124940982381 no 745 0.226086570657044 269 691747
SGTC_1420 4'-methoxyflavone 42 µM 0.751754658630386 0.218137790048409 no 746 0.226099306782272 250 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.751261369104701 0.218287487701289 no 747 0.226247686639683 257 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1616 st002734 56.1 µM 0.750160548215112 0.218621765095322 no 748 0.226579008210487 245 4026101
SGTC_1456 k015-0012 13 µM 0.749756792986292 0.218744444010875 no 749 0.226700597791708 258 2989616
SGTC_1930 st074634 34.3 µM 0.746114167206295 0.219853026405442 no 750 0.227799225948974 258 684253 YOR116C RPO31
SGTC_2223 6903751 107.57 µM 0.744173154319972 0.220445061117721 no 751 0.22838586344858 248 5598863
SGTC_3183 9108214 49.47 µM 0.743962135741404 0.220509479608255 no 752 0.228449691279431 232 4974831
SGTC_872 0588-0139 234 µM 0.743396792850258 0.220682117259793 no 753 0.228620742718081 239 2047100
SGTC_1092 toremifene 6.32 µM 0.742922510340904 0.220827007679287 no 754 0.228764298184224 265 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3077 9117319 49.47 µM 0.74238138864192 0.220992383569898 no 755 0.228928146272531 283 17154678
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.740386331990484 0.221602718528108 no 756 0.229532804934409 257 2374 Ca(2+)-ATPase inhibitor.
SGTC_77 0828-0286 12.516 µM 0.740105423381338 0.221688732409593 no 757 0.229618014088263 241 745345
SGTC_2437 5741531 144.16 µM 0.739962947735547 0.221732365572864 no 758 0.229661238578874 266 2262990
SGTC_764 1951-2361 146 µM 0.73988049840842 0.221757617918465 no 759 0.229686254270087 255 5438930
SGTC_2098 5376439 882.5 nM 0.739642382847544 0.221830556499203 no 760 0.229758508731658 244 2844116
SGTC_2848 9016370 25.97 µM 0.738633655909153 0.222139697530963 no 761 0.230064740828074 237 7894410
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.737318032137585 0.222543261406781 no 762 0.230464484468983 249 4213774
SGTC_2367 9070478 135.38 µM 0.733712112697046 0.223651507487423 no 763 0.231562107313988 250 572802
SGTC_846 0335-0850 148 µM 0.733392780832814 0.223749802223979 no 764 0.231659450502229 256 6819598
SGTC_2814 7977482 42.97 µM 0.732499255219291 0.224024972149351 no 765 0.231931948568936 260 6456762
SGTC_744 1594-0068 283 µM 0.732402762361677 0.224054699563013 no 766 0.231961386623718 268 668392
SGTC_1480 1070-0044 41.2 µM 0.731623498176303 0.224294856524297 no 767 0.232199200887798 253 3124987
SGTC_2063 5246145 200 µM 0.73134126564223 0.224381872186833 no 768 0.232285365498769 255 711240
SGTC_1018 4259-0013 28.1 µM 0.730097043664479 0.224765709038796 no 769 0.232665434147641 257 6801262
SGTC_862 0452-0056 10.2 µM 0.729135630616186 0.225062555446454 no 770 0.232959350607442 253 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2322 7413319 38.22 µM 0.728209353970764 0.225348763117616 no 771 0.233242720360482 251 1840400
SGTC_844 0330-0132 15.3 µM 0.727401033967222 0.22559869199554 no 772 0.233490160644923 256 2828079
SGTC_170 4197-0004 226 µM 0.726482922396882 0.22588275809397 no 773 0.233771386485586 277 218692
SGTC_2906 7926292 26.41 µM 0.725730129291866 0.226115825066288 no 774 0.234002113796575 278 2966319
SGTC_2089 5281248 129.67 µM 0.725405503766706 0.226216372014054 no 775 0.234101648804851 252 2737878
SGTC_768 0384-0033 77.3 µM 0.724278470386913 0.226565646463649 no 776 0.234447395917813 247 3965305 YMR134W ERG29
SGTC_2704 st078022 71.1 µM 0.722975620005375 0.226969786764684 no 777 0.234847431351429 264 54697681
SGTC_91 0417-1751 58.384 µM 0.722810151612469 0.227021143645781 no 778 0.234898264801367 263 6795624
SGTC_191 3914-0123 66.505 µM 0.722802411586969 0.227023546099236 no 779 0.234900642759016 263 3144412
SGTC_1262 0737-0114 49.6 µM 0.721886631643786 0.227307899395579 no 780 0.235182090488662 264 765919
SGTC_2068 5226020 147 µM 0.720436089743895 0.227758708807829 no 781 0.235628268080303 279 1810509
SGTC_2944 9067346 25.62 µM 0.72015175229354 0.227847136111259 no 782 0.235715783196688 272 6473075
SGTC_20 0481-0013 4.944 µM 0.718275990894905 0.228430970916615 no 783 0.236293565427701 265 182045
SGTC_775 4577-0580 57.3 µM 0.717143614493576 0.228783832025808 no 784 0.236642743306576 266 2006902
SGTC_3276 9139060 49.47 µM 0.716171111707742 0.229087118813335 no 785 0.236942849232781 291 4870619
SGTC_82 0054-0107 293.755 µM 0.714168050325853 0.229712507873687 no 786 0.237561635298671 257 3104697
SGTC_3288 9119690 36.221 µM 0.713662094851143 0.229870626710285 no 787 0.23771807533262 284 17595618 YKL019W RAM2
SGTC_1296 1068-0102 11.9 µM 0.713370317706116 0.229961839231437 no 788 0.237808317705775 254 767053
SGTC_3131 9127911 49.47 µM 0.712653889714783 0.230185887864314 no 789 0.238029978014227 257 45595681
SGTC_2152 5568786 200 µM 0.712215668196304 0.230322993110222 no 790 0.238165618017068 275 5399883
SGTC_3344 9148862 3.898 µM 0.712173460418064 0.230336200960393 no 791 0.238178684565906 281 4905352
SGTC_3143 9086658 49.47 µM 0.711492250797001 0.230549426743955 no 792 0.238389625576233 272 25236626
SGTC_2725 haloperidol 53.21 µM 0.711389094941759 0.230581725227047 no 793 0.238421577377386 265 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3164 9100705 49.47 µM 0.708234693087228 0.231570600187952 no 794 0.239399762529422 239 17174235
SGTC_997 3996-0078 137 µM 0.706950946558941 0.231973718276873 no 795 0.239798481043755 255 735687
SGTC_354 2783-3500 4.88 µM 0.705651694627749 0.232382102878435 no 796 0.240202383980733 263 6740761
SGTC_1403 3909-7815 62.9 µM 0.70479664125981 0.232651083759801 no 797 0.240468399532826 267 6615483
SGTC_2256 7954252 200 µM 0.703985383841314 0.232906447317902 no 798 0.240720937983293 270 2972920
SGTC_996 3970-0799 1.8 µM 0.703547598202667 0.233044315950705 no 799 0.240857277361718 279 6615648 YGL040C HEM2
SGTC_1632 st005650 90 µM 0.70217811029411 0.233475891256433 no 800 0.241284047474582 263 2759605
SGTC_2065 5221596 34.26 µM 0.702116750390659 0.233495238358229 no 801 0.241303178522167 260 788581
SGTC_1096 rimcazole 32.2 µM 0.701324097310496 0.233745245986244 no 802 0.241550389300195 270 18528119 A dopamine reuptake inhibitor.
SGTC_2642 cholecalciferol 100 µM 0.700766576105007 0.233921180429848 no 803 0.241724350053406 263 9821465 A vitamin D precursor, similar to steriods.
SGTC_7 0192-1582 4.227 µM 0.699085203549206 0.234452207567426 no 804 0.242249392451403 297 252616
SGTC_1864 st057645 30.4 µM 0.698535083040061 0.234626096582886 no 805 0.242421312754255 276 688666
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.696185078464441 0.235369718137433 no 806 0.243156465549054 281 6708784 An antioxidant flavonoid
SGTC_1402 3909-7673 35.9 µM 0.695858878355195 0.235473041692475 no 807 0.243258606036382 260 5328014
SGTC_3182 9108849 49.47 µM 0.695672941488823 0.235531948204623 no 808 0.243316837367971 256 17133045
SGTC_2244 6635614 200 µM 0.695144836206929 0.235699301154518 no 809 0.243482269388907 272 836499
SGTC_1159 4092-0538 61.2 µM 0.694264695791153 0.235978357289424 no 810 0.24375811340649 287 717301
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.693971738479337 0.236071282312061 no 811 0.243849966300595 272 2724 A muscle relaxant with antifungal properties.
SGTC_1334 1486-0610 236 µM 0.693403339390607 0.236251633983002 no 812 0.244028233590379 251 3742339
SGTC_3337 9144342 33.5465 µM 0.689279221734851 0.237562476519288 no 813 0.245323785525394 254 17682949
SGTC_2329 6138490 200 µM 0.688760542210045 0.237727619875137 no 814 0.245486985040041 277 720019
SGTC_224 benfluorex 43.875 µM 0.687126073738575 0.238248433052723 no 815 0.246001642394068 289 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1091 telmisartan 47.6 µM 0.6869123219442 0.238316589914486 no 816 0.246068990803034 281 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_760 0568-0725 82.9 µM 0.686137590114978 0.238563710252333 no 817 0.246313174338876 280 3916171
SGTC_2809 7964133 12.99 µM 0.685632779759025 0.238724807741558 no 818 0.246472352652582 285 1253665
SGTC_2343 7990716 14.84 µM 0.685426173224981 0.238790758165332 no 819 0.246537516336395 287 6456862
SGTC_2567 aureobasidin a 60 nM 0.685230614140853 0.238853191336957 no 820 0.246599204157142 289 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1618 st003135 44.5 µM 0.683503648443753 0.239404920741243 no 821 0.24714432278173 298 1270615
SGTC_312 4092-0653 6.84 µM 0.683128760010835 0.239524781631096 no 822 0.247262741809337 274 1148278
SGTC_392 N-ethylmaleimide 8.33 µM 0.682293088839768 0.239792083772588 no 823 0.247526821138631 265 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2938 9059746 27.26 µM 0.68223854779711 0.239809535210868 no 824 0.247544061817428 275 6471769
SGTC_654 1124-0271 80.9 µM 0.680247140918712 0.240447197779584 no 825 0.248173993966531 272 5403748
SGTC_2314 7727897 200 µM 0.678095273417992 0.241137277747845 no 826 0.248855643706132 258 900724
SGTC_1579 chlormadinone acetate 49.4 µM 0.677888949404405 0.241203500081997 no 827 0.248921053541095 284 45114258 A steroidal progestin.
SGTC_712 r015-0009 80.6 µM 0.675911464302347 0.2418387003451 no 828 0.249548429263462 279 6813872 YLR060W FRS1
SGTC_2289 7946404 165.07 µM 0.675758295686231 0.241887938433373 no 829 0.249597058477122 270 1246120 YPR165W RHO1
SGTC_1162 k048-0130 20.1 µM 0.67513847228372 0.242087244432498 no 830 0.24979389642708 279 6797406
SGTC_655 k060-0012 42 µM 0.673700811613023 0.242549870966628 no 831 0.250250772889067 289 5994525
SGTC_1692 fluoroquinolonic acid 71 µM 0.673674828983693 0.242558236350224 no 832 0.250259034024496 284 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_3004 9076122 71.4286 µM 0.673125151728652 0.242735247395768 no 833 0.250433836912243 288 44782551
SGTC_2917 7979103 53.79 µM 0.672754470915451 0.242854656177188 no 834 0.250551753656625 271 2980565
SGTC_2474 5321570 43.32 µM 0.672655514176128 0.24288653885228 no 835 0.250583237617613 284 2841384
SGTC_2155 5570423 76 µM 0.671913123054964 0.243125800584643 no 836 0.250819502739767 290 797402
SGTC_2090 5301565 104.445 µM 0.671556274907372 0.243240852827614 no 837 0.250933111207723 274 2056344
SGTC_2690 usnic acid 100 µM 0.670409973373069 0.243610633611638 no 838 0.251298239304416 297 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_285 1486-1325 46 µM 0.669335628466792 0.243957477598298 no 839 0.251640702098324 286 22310230
SGTC_1347 1493-0251 600 nM 0.668272833462184 0.244300854762662 no 840 0.25197972559095 268 3986378
SGTC_1448 4255-0083 152 µM 0.667384951654772 0.244587919040325 no 841 0.252263137788988 307 5399660
SGTC_3104 9120930 49.47 µM 0.667341057092895 0.244602115461109 no 842 0.252277153307966 284 17014836
SGTC_3328 9140624 29.0385 µM 0.663411529216295 0.245874803360616 no 843 0.25353351197222 277 4904392
SGTC_2746 daunorubicin 9.88 µM 0.661628132714379 0.246453576734842 no 844 0.254104786627475 256 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_186 3455-3465 67.277 µM 0.656313781792422 0.24818258633289 no 845 0.255811125938758 289 755278
SGTC_1041 0206-0046 107 µM 0.655715721367227 0.248377567829716 no 846 0.256003525753525 294 50494
SGTC_2304 7443016 91.4 µM 0.652465638231054 0.249438595912299 no 847 0.257050416400878 294 939854
SGTC_720 r052-1644 49.9 µM 0.651983783047519 0.249596108026565 no 848 0.257205817039034 285 1422863 YOR257W CDC31
SGTC_2185 6113692 200 µM 0.651748419976422 0.249673064318382 no 849 0.257281740524548 294 874150
SGTC_2710 st078562 53.7235 µM 0.651564252547072 0.249733290039275 no 850 0.257341157428349 297 17250908
SGTC_33 0986-0033 35.816 µM 0.651321013046016 0.249812845102222 no 851 0.257419643350455 257 2848082
SGTC_2284 7945075 39.21 µM 0.650470861052141 0.250091005499947 no 852 0.257694058976052 299 1245402
SGTC_1385 3091-4834 14.1 µM 0.650178039118652 0.250186851650508 no 853 0.257788612418981 281 4072814
SGTC_1709 st033179 39.1045 µM 0.645862065575745 0.251601808064577 no 854 0.259184344322665 283 573381
SGTC_328 k915-0120 63.5 µM 0.644882817932597 0.251923433715862 no 855 0.259501563585278 269 6624543
SGTC_416 estradiol valerate 100 µM 0.644716729842514 0.251978005466693 no 856 0.259555386344021 299 13791 A steroid.
SGTC_2964 9083345 53.42 µM 0.642871014949416 0.252584873697322 no 857 0.260153899236434 289 17741579
SGTC_2796 7949634 45.45 µM 0.642538505579237 0.252694284061119 no 858 0.26026179814968 300 2971588
SGTC_1196 1588-0294 184 µM 0.642171307817967 0.252815137441342 no 859 0.260380980194477 309 6144269
SGTC_1404 3909-7820 48.3 µM 0.642123128647102 0.252830996592323 no 860 0.260396619881595 281 23741373
SGTC_1891 st059073 26.2 µM 0.641555291289232 0.253017951226041 no 861 0.260580984922298 295 688754
SGTC_1929 genistein trimethyl ether 50.5 µM 0.641416050019652 0.253063806090121 no 862 0.260626203938659 280 136420
SGTC_1807 st050092 58.9 µM 0.641086009010275 0.253172512487717 no 863 0.260733401868823 295 5008496
SGTC_3116 9124943 49.47 µM 0.640739751918235 0.253286586407948 no 864 0.260845891195526 261 41905195 YPL160W CDC60
SGTC_2754 granisetron 64.02 µM 0.640731348560652 0.25328935521832 no 865 0.260848621523619 302 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1567 st069303 68.4 µM 0.640437707993675 0.253386116424581 no 866 0.260944037273111 301 5581319
SGTC_346 4513-0042 7.16 µM 0.639528374309765 0.253685885633005 no 867 0.261239630541407 281 2827372
SGTC_1987 st072290 61.9 µM 0.638284626336886 0.254096198596466 no 868 0.261644208857235 302 54697379
SGTC_2995 9067767 71.4286 µM 0.633031247507241 0.255833123419676 no 869 0.263356618850883 278 11673567
SGTC_1973 st070275 50.2 µM 0.633019206865693 0.255837111523479 no 870 0.263360550223852 270 17118334
SGTC_2220 6782180 200 µM 0.632604001836458 0.255974655669607 no 871 0.263496136565316 275 833803
SGTC_2216 7189485 200 µM 0.632080959010992 0.256147977925361 no 872 0.263666988328512 274 731273
SGTC_2728 chlorpromazine 9.18 µM 0.631295601189655 0.256408339169706 no 873 0.263923631285625 330 2726 A thorazine and dopamine antagonist.
SGTC_2107 5363541 170.161 µM 0.628390129943264 0.257372756307999 no 874 0.264874200627326 280 244052
SGTC_666 0272-0154 136 µM 0.627640006619492 0.257622051587095 no 875 0.265119897269806 295 6870312
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.625913363969556 0.258196358499846 no 876 0.265685884220114 311 7104
SGTC_67 0335-0847 266 µM 0.623445502368202 0.259018356543867 no 877 0.266495902180835 320 4552207 YOR254C SEC63
SGTC_1268 0828-0275 2.46 µM 0.623021016054911 0.25915988120191 no 878 0.266635355703905 305 745337
SGTC_2792 7535235 81.82 µM 0.62246005003012 0.25934696979263 no 879 0.266819702531298 286 1281891
SGTC_941 3237-0776 460 µM 0.621066972047273 0.259811878882111 no 880 0.267277779598757 298 760008
SGTC_1550 gossypolone 36.6 µM 0.620194207311885 0.260103363823057 no 881 0.267564967385948 289 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2684 capsaicin 100 µM 0.619706552559653 0.26026630356844 no 882 0.267725500446233 313 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1547 harmine 94.2 µM 0.619218478378278 0.260429436105234 no 883 0.2678862201636 291 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1785 bathophenanthroline 24 µM 0.617293269760104 0.261073425563072 no 884 0.268520652615314 280 72812 An iron chelator.
SGTC_2441 5730946 39.09 µM 0.616554751814412 0.261320679632554 no 885 0.268764223799433 284 1774275
SGTC_2214 7179297 48.276 µM 0.615767419677549 0.261584408991972 no 886 0.269024016601301 298 769744
SGTC_1077 5-fluorocytosine 377 nM 0.614936543140872 0.261862872321351 no 887 0.26929831419633 323 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_652 0437-0092 114 µM 0.614706793080892 0.261939898509977 no 888 0.269374186419095 284 3091274
SGTC_660 4031-1742 102 µM 0.612948066139214 0.262529915308952 no 889 0.269955339864411 290 6738706
SGTC_323 4013-0906 34.3 µM 0.612764975977546 0.262591377372647 no 890 0.270015876191127 272 2910086
SGTC_2243 6634756 200 µM 0.61136041907397 0.263063121925731 no 891 0.270480500064334 259 885676
SGTC_3347 9188721 44.724 µM 0.611280111679822 0.263090107626597 no 892 0.270507077615848 304 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2695 st077686 51.995 µM 0.608289053523241 0.264096199662116 no 893 0.271497889920404 287 2876092
SGTC_637 1181-0519 7.26 µM 0.607991666114751 0.264196337877467 no 894 0.27159650062389 298 6252091 YGR060W ERG25
SGTC_3109 9122853 49.47 µM 0.606880366247936 0.264570713050007 no 895 0.271965154366944 337 1234709
SGTC_540 1187-0821 17.3 µM 0.606678382180854 0.264638786501921 no 896 0.272032185667294 308 847520
SGTC_596 1155-0152 116 µM 0.6063972035096 0.264733565256807 no 897 0.272125512505896 305 280313
SGTC_302 1094-0063 18.9 µM 0.606221462132794 0.264792812329574 no 898 0.272183851424421 295 5440289
SGTC_3326 9140064 16.379 µM 0.606123369636481 0.264825884839326 no 899 0.272216416807033 321 1868434
SGTC_2287 7945887 168.79 µM 0.605756819787159 0.264949488036601 no 900 0.272338123536094 301 1245853
SGTC_2139 5578692 56.4705 µM 0.605550749607009 0.265018989227405 no 901 0.272406557551572 297 650991 YMR113W FOL3
SGTC_2363 9053361 176 µM 0.604845344322933 0.265256971031555 no 902 0.272640880813745 322 6469797 YMR079W SEC14
SGTC_946 3434-1334 87.4 µM 0.604578262389313 0.265347104477396 no 903 0.272729626849621 294 4047976
SGTC_451 chloral hydrate 100 µM 0.604426154551317 0.265398443999822 no 904 0.272780175676394 320 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2393 9031399 185.94 µM 0.604043616041669 0.26552758088754 no 905 0.27290732229422 316 1526623 YDL150W RPC53
SGTC_1253 0550-0034 176 µM 0.599226181462685 0.267156568221587 no 906 0.274511032968384 291 5969915
SGTC_845 0330-0138 4.51 µM 0.597291082578497 0.2678123278638 no 907 0.275156528558363 318 9039800
SGTC_201 4262-0159 12.803 µM 0.597042647286731 0.267896575457722 no 908 0.275239453820766 305 1341029
SGTC_1867 st057372 64 µM 0.595966624535913 0.268261622611995 no 909 0.275598761630469 292 688837
SGTC_2997 9067075 71.4286 µM 0.595849316696869 0.268301435121192 no 910 0.275637947252483 314 27209819
SGTC_1246 0422-0085 105 µM 0.595835072092825 0.268306269727068 no 911 0.275642705720056 326 264295
SGTC_1090 efavirenz 20.7 µM 0.595714392493066 0.268347230033487 no 912 0.275683020848669 308 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2224 6650123 117.647 µM 0.594488335175553 0.268763548861028 no 913 0.276092770954853 306 2908370
SGTC_273 hydroxyurea 18.1 mM 0.592715369009858 0.269366148777521 no 914 0.276685827070951 316 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_736 0958-0254 92.6 µM 0.592366713264713 0.269484730371216 no 915 0.276802525613761 316 6812352
SGTC_446 go6976 132 µM 0.588787059494567 0.270703720665693 no 916 0.278002063842347 312 3501 A protein kinase C inhibitor.
SGTC_2529 gangaleoidin 93.61 µM 0.588520238714301 0.27079469209101 no 917 0.278091576684579 321 4565183
SGTC_2511 berberine 10.47 µM 0.586900422547793 0.27134728894256 no 918 0.278635292995301 313 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1844 rapamycin 4 nM 0.586845769534701 0.271365943497496 no 919 0.278653647146985 297 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1691 st019933 84.6 µM 0.586492149190582 0.27148665914918 no 920 0.278772417888472 336 6176082
SGTC_877 0771-0151 33.1 µM 0.585708629371239 0.271754225175924 no 921 0.279035667052185 304 6166523
SGTC_2427 5545055 42.75 µM 0.584330239111006 0.272225253222021 no 922 0.279499075649586 310 5372858
SGTC_988 1497-1057 103 µM 0.583832819526859 0.272395332649129 no 923 0.279666397590611 326 3533044
SGTC_1054 3429-0080 167 µM 0.582779461349635 0.272755674666613 no 924 0.280020886483305 317 1162877
SGTC_2076 5212012 200 µM 0.582476761658434 0.272859268565432 no 925 0.280122794937459 305 604802
SGTC_157 1348-1695 65.819 µM 0.582458599885892 0.272865484748366 no 926 0.280128909945858 313 5380510
SGTC_1901 st060216 58.6 µM 0.580677491402098 0.273475441123759 no 927 0.280728917278751 308 688792
SGTC_3057 9095946 49.47 µM 0.580466580064788 0.273547714249551 no 928 0.280800008749201 316 24540043
SGTC_2192 5915882 198.485 µM 0.580354440037107 0.273586145194931 no 929 0.280837811112579 306 2876149
SGTC_431 k089-0097 107 µM 0.579505900400995 0.273877030518121 no 930 0.281123933241096 304 5499420
SGTC_867 0518-0118 155 µM 0.579227025806075 0.273972664053889 no 931 0.281217998700407 320 6848158
SGTC_2863 9028737 58.44 µM 0.578900877307803 0.274084530006695 no 932 0.281328029104415 320 6460917
SGTC_2855 9016525 58.44 µM 0.578359564852597 0.274270245025885 no 933 0.281510693699171 321 43811474
SGTC_2443 5493264 126.67 µM 0.57717529347073 0.274676764777067 no 934 0.281910522646354 327 5340055
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.576138362868323 0.275032951313052 no 935 0.282260831488893 326 364106
SGTC_1898 st060199 18.6 µM 0.575874567007405 0.275123601703946 no 936 0.282349983712915 297 688866
SGTC_1265 0819-1001 68.8 µM 0.575773042396684 0.275158493380655 no 937 0.282384298493381 342 3106768
SGTC_150 3970-0969 77.2 µM 0.575313689106088 0.275316389782084 no 938 0.282539582538386 325 6615640
SGTC_410 α-linolenic acid 100 µM 0.571397610869357 0.276664295749687 no 939 0.283865074113056 305 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2235 salicylic acid 500 µM 0.570200146567135 0.277077105139643 no 940 0.284270978351196 303 338 A COX inhibitor and kinase inhibitor.
SGTC_2222 6885208 172.143 µM 0.569917300655422 0.277174656379726 no 941 0.284366895065745 307 609514
SGTC_341 1486-1430 230 µM 0.569256205259194 0.27740272828528 no 942 0.284591141381234 317 2054753 YPL210C SRP72
SGTC_1812 st052057 4.327 µM 0.56653955488216 0.278340910001913 no 943 0.285513525894062 299 3645418
SGTC_383 2324-0395 7.37 µM 0.566148524595435 0.278476077587014 no 944 0.285646409512185 310 3146421
SGTC_642 0335-0876 158 µM 0.563348536911696 0.27944488363703 no 945 0.286598786631717 322 6812350
SGTC_2413 inermin 26.06 µM 0.563346652830093 0.279445536086926 no 946 0.286599427982774 345 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1272 0839-0021 27 µM 0.558371308542711 0.281171053497812 no 947 0.288295430350484 336 5027250
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.556814165257819 0.281712147374786 no 948 0.288827202315849 310 165521
SGTC_2300 7976697 71.57 µM 0.55676895024032 0.281727866700856 no 949 0.288842650358786 303 2236109
SGTC_2646 retinol 96.75 µM 0.554403443654834 0.282550841242204 no 950 0.289651384934224 328 445354 A vitamin A analog and teratogen.
SGTC_1007 4101-0031 70 µM 0.55393777241344 0.282712987235181 no 951 0.28981071673476 348 1146276
SGTC_1934 st074720 32.6 µM 0.553135644571924 0.282992391679164 no 952 0.290085265254721 312 17250992
SGTC_3024 9090631 49.47 µM 0.54988386236189 0.284126437900987 no 953 0.291199516749653 301 25236383
SGTC_1516 st013856 110 µM 0.548848631729523 0.284487926065464 no 954 0.291554666422048 319 5281404 A mutagen and neurotoxin.
SGTC_523 1934-0222 13.7 µM 0.548351102096743 0.28466173463416 no 955 0.291725422427832 365 1361595
SGTC_3293 9120939 62.045 µM 0.547467135708764 0.284970667225096 no 956 0.292028921417631 331 934087
SGTC_1108 betulinic acid 729.144 nM 0.545431719399127 0.28568262109785 no 957 0.292728314902308 294 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1956 st077085 54 µM 0.544820883573732 0.285896446010893 no 958 0.292938357076164 340 24208685
SGTC_2639 lactacystin 53 µM 0.544802494588952 0.285902884309787 no 959 0.292944681401803 309 3870 A proteasome inhibitor.
SGTC_735 3076-0345 636 µM 0.544380057663563 0.28605080569746 no 960 0.293089983030422 313 2888990
SGTC_556 4058-0063 51.5 µM 0.544060763625351 0.28616263448445 no 961 0.293199829753142 332 6615692
SGTC_2709 st078560 56 µM 0.543704212504744 0.286287536640615 no 962 0.293322516582779 344 17250903
SGTC_1777 st045864 34.765 µM 0.543445082273973 0.286378327869953 no 963 0.293411696468969 341 4691462
SGTC_278 4092-0821 23.9 µM 0.543136066300299 0.286486615385976 no 964 0.293518060994031 314 877900
SGTC_3345 9148410 3.559 µM 0.542880997903889 0.286576012852841 no 965 0.293605869999408 326 4903596
SGTC_411 enrofloxacin 100 µM 0.542751892873649 0.286621267181519 no 966 0.293650319906892 331 71188 A bacterial gyrase inhibitor.
SGTC_2673 kobusone 100 µM 0.542601448184479 0.286674005834554 no 967 0.29370212083077 341 6710676 An epoxy ketone and protein crosslinker.
SGTC_980 1473-0395 201 µM 0.542208773282496 0.286811680393724 no 968 0.293837346074249 331 768876
SGTC_1793 st048256 72.231 µM 0.541990450422512 0.286888239463746 no 969 0.293912542255399 329 672022
SGTC_516 3992-2719 87.3 µM 0.541293469140758 0.287132714007505 no 970 0.294152660623252 310 5350887 YDR037W KRS1
SGTC_2001 4023502 57.655 µM 0.540573222904076 0.287385452592882 no 971 0.2944008892387 317 108941 YCR052W RSC6
SGTC_1169 aniline yellow 25.8 µM 0.540306786945596 0.287478973174745 no 972 0.294492739317913 331 6051 A DNA damaging agent.
SGTC_2926 9010726 65.15 µM 0.540245095977559 0.287500629117563 no 973 0.294514008303913 316 2994293
SGTC_708 3448-5400 146 µM 0.538897735373634 0.287973797683803 no 974 0.294978709963029 335 3462195
SGTC_1269 0831-0796 3.05 µM 0.537545068086249 0.288449199353229 no 975 0.295445581418862 328 927758
SGTC_470 aa-861 153 µM 0.536248437012734 0.288905253759982 no 976 0.295893430835942 302 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_493 zm226600 134 µM 0.534809592639184 0.289411724623959 no 977 0.296390764568301 336 5240098 A potassium channel opener. YCR052W RSC6
SGTC_777 1315-0167 517 µM 0.534372141630249 0.289565789305089 no 978 0.29654204457724 319 4221767
SGTC_2251 lansoprazole 556 µM 0.533743331499465 0.289787315670402 no 979 0.296759562657413 335 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_755 1995-0008 37.3 µM 0.533445067371894 0.289892420284067 no 980 0.296862763756947 307 689533
SGTC_2280 7785178 200 µM 0.531946269450012 0.29042084871627 no 981 0.297381604894302 316 2954328
SGTC_820 1582-0060 59.9 µM 0.530666778683787 0.29087231290826 no 982 0.297824855603721 318 3848840
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.530312928348441 0.290997225738514 no 983 0.297947492234647 349 5024745
SGTC_3015 9080845 49.47 µM 0.530146067804462 0.291056137931817 no 984 0.298005330362128 329 5296973
SGTC_1746 st038117 42 µM 0.528391468033499 0.291675958268431 no 985 0.298613829027589 316 2898218
SGTC_1759 st043059 70 µM 0.526903268162367 0.29220215335543 no 986 0.299130382109724 345 669426
SGTC_911 3456-4043 236 µM 0.526159018769329 0.292465469305071 no 987 0.299388862572517 338 914281
SGTC_1644 st010134 20.9 µM 0.526148760311598 0.292469099525013 no 988 0.29939242607897 329 3818134
SGTC_1147 3809-1045 12.3 µM 0.524067362216124 0.293206088786766 no 989 0.300115844082248 317 325925
SGTC_645 0845-0943 5.41 µM 0.523302959137113 0.293476967507624 no 990 0.300381721034367 327 1885106
SGTC_408 cantharidin 100 µM 0.522162594757359 0.293881289563002 no 991 0.300778563651245 318 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1453 4237-0541 195 µM 0.5214975513256 0.294117203008106 no 992 0.301010105467795 308 739892
SGTC_3296 9122258 64.045 µM 0.520973147693118 0.294303288441666 no 993 0.301192738708457 328 4730474
SGTC_1093 fluphenazine 7.97 µM 0.520892997918356 0.294331734501895 no 994 0.301220656743639 343 6602611 An atypical antipsychotic.
SGTC_1437 4092-1038 11.6 µM 0.518470163822715 0.295192224317144 no 995 0.302065135907631 338 3977136
SGTC_942 3253-1115 227 µM 0.517035785501251 0.295702200972949 no 996 0.302565589134474 369 46497897
SGTC_2644 guaiazulene 100 µM 0.516637857000148 0.295843751567148 no 997 0.30270449182999 322 3515 A coloring agent.
SGTC_1151 3909-8316 15.3 µM 0.516243663166315 0.295984004348771 no 998 0.302842119044399 341 800431
SGTC_714 4296-0578 26.1 µM 0.515816576333385 0.29613599478648 no 999 0.302991261998179 345 1589775
SGTC_3187 9109394 49.47 µM 0.513860616178993 0.296832533396772 no 1000 0.303674722207882 318 17098090
SGTC_1306 1185-0270 9.02 µM 0.512872445824988 0.297184716443922 no 1001 0.304020274486682 348 1548076
SGTC_2264 7948757 110.76 µM 0.511556664265372 0.297653956094336 no 1002 0.304480660661774 320 2971411
SGTC_1202 1988-0068 29.6 µM 0.51052067326917 0.298023653370759 no 1003 0.304843367501937 318 2850480
SGTC_751 0833-0568 350 µM 0.508971055596075 0.298577030502419 no 1004 0.305386256288802 351 6954252
SGTC_1502 4534-4282 27.7 µM 0.50722787208274 0.299200089011771 no 1005 0.305997470302755 362 3278949
SGTC_130 0136-0219 337.655 µM 0.506714362811056 0.299383742839355 no 1006 0.30617762568023 372 234244
SGTC_750 4073-0104 132 µM 0.506285543047803 0.299537147078606 no 1007 0.306328105209728 321 22330957
SGTC_187 1488-2104 32.728 µM 0.50413782287797 0.300305999226965 no 1008 0.307082264852751 333 2852859
SGTC_22 0964-0034 14.468 µM 0.503434994939783 0.300557794825047 no 1009 0.307329236412368 348 138402
SGTC_3214 9129694 49.47 µM 0.501479703121615 0.301258799947299 no 1010 0.30801677941908 374 17158655
SGTC_2458 5808907 16.39 µM 0.50146778707537 0.301263074307719 no 1011 0.308020971551033 371 2731747
SGTC_424 splitomicin 100 mM 0.500944090948971 0.301450954359488 no 1012 0.308205235524194 346 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_776 4476-4378 112 µM 0.499643738759585 0.301917693673518 no 1013 0.308662977125232 355 2892008
SGTC_155 k072-0202 43.6 µM 0.49899733333166 0.302149830663857 no 1014 0.308890631336208 358 5857737
SGTC_469 w7 172 µM 0.496247460626057 0.303138258534817 no 1015 0.309859914803943 340 45115570 A P450 inhibitor.
SGTC_2595 hexamethylquercetagetin 100 µM 0.495148659439251 0.303533621059992 no 1016 0.310247593998629 375 386331
SGTC_2372 9071633 200 µM 0.494910102730715 0.303619487188475 no 1017 0.310331789498546 326 21321366
SGTC_2470 5664817 21.68 µM 0.494842998276504 0.303643642727407 no 1018 0.310355474937992 338 2859561
SGTC_647 0140-0236 81 µM 0.494215122074871 0.303869700396199 no 1019 0.310577130570942 343 990837
SGTC_1711 st032263 62.8 µM 0.49391870274048 0.303976447932031 no 1020 0.310681797743344 361 3958979
SGTC_3269 9137823 49.47 µM 0.492911628870031 0.304339243616526 no 1021 0.311037515080558 328 17682936
SGTC_984 1492-0255 2.91 µM 0.492418017602111 0.304517136140209 no 1022 0.311211932335497 353 1585198
SGTC_2306 7482397 179.52 µM 0.490658307236847 0.305151694123935 no 1023 0.311834069752307 374 891448
SGTC_309 k408-0051 1.48 µM 0.489459589549662 0.305584291902732 no 1024 0.312258178628296 359 3640463
SGTC_1442 4112-3290 3 µM 0.488012257915496 0.306106972264992 no 1025 0.31277057930289 342 704353
SGTC_2591 skatole 100 µM 0.487520913675584 0.306284503132319 no 1026 0.31294461289171 368 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2933 9026794 32.47 µM 0.486744809358606 0.306565015231008 no 1027 0.313219593113828 366 17586027
SGTC_886 0866-0150 153 µM 0.486020839754824 0.30682678616829 no 1028 0.31347619523841 358 271463
SGTC_1838 st055369 84.5 µM 0.485800877598097 0.306906339002779 no 1029 0.313554176011748 311 676036
SGTC_694 1315-0438 43.2 µM 0.484435866413166 0.307400220338505 no 1030 0.314038284674665 351 6793154
SGTC_1969 st069479 40.1 µM 0.480238535145637 0.308921063444765 no 1031 0.315528894368444 354 3895485
SGTC_2203 7227154 166.4 µM 0.479886062217396 0.309048926699858 no 1032 0.315654206211807 341 896304
SGTC_1640 st009078 66.4 µM 0.479717472328273 0.309110092633311 no 1033 0.315714151103722 358 690618
SGTC_1740 st038286 13.222 µM 0.478816808199382 0.309436951332294 no 1034 0.316034479067281 318 716786
SGTC_3041 9091929 49.47 µM 0.478573802947227 0.309525165858583 no 1035 0.316120929388174 352 25236887
SGTC_989 1501-0895 10.3 µM 0.47708029031402 0.310067574058073 no 1036 0.316652474541262 352 2830112
SGTC_3184 9108758 49.47 µM 0.477028905260656 0.310086243250809 no 1037 0.316670769366787 348 902885
SGTC_2124 5246320 200 µM 0.476924638126632 0.310124127040086 no 1038 0.316707893388603 351 579342
SGTC_794 k038-0031 316 µM 0.472478057608973 0.311741592148192 no 1039 0.318292800057409 346 6624242
SGTC_533 1222-0222 6.71 µM 0.470768036646926 0.312364590965633 no 1040 0.318903196181823 371 3982874
SGTC_579 4491-1009 110 µM 0.468459376026127 0.313206538947662 no 1041 0.319728057765274 372 1271041
SGTC_3245 9134821 49.47 µM 0.467827787148269 0.31343704377607 no 1042 0.319953873858244 365 17014901
SGTC_969 1313-0238 134 µM 0.467129049271 0.31369214024056 no 1043 0.320203775920543 363 5212874
SGTC_2239 6685329 187.64 µM 0.465003065536953 0.314468845761039 no 1044 0.320964630647708 312 805680
SGTC_1223 0764-0573 147 µM 0.463403284542938 0.315053850920001 no 1045 0.321537662388594 340 1609797
SGTC_1284 0929-0043 16 µM 0.463376997188152 0.315063467515119 no 1046 0.321547081909918 354 1239883
SGTC_245 methotrexate 289.6 µM 0.463332681298829 0.315079679698821 no 1047 0.321562961837594 339 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_3119 9125183 49.47 µM 0.462194612270259 0.315496144076104 no 1048 0.321970883274245 330 22695334
SGTC_2734 clemastine 41.6 µM 0.459244011064053 0.316576976511252 no 1049 0.323029474495131 393 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_129 0088-0017 176.636 µM 0.458805703432728 0.316737666632269 no 1050 0.323186849349841 358 182446
SGTC_1287 0971-0001 34.6 µM 0.456355756356019 0.317636490054292 no 1051 0.324067087863365 339 4665869
SGTC_689 0833-0039 98 µM 0.454200546298856 0.318428071848198 no 1052 0.324842244939689 396 5374726
SGTC_668 1682-0499 62.6 µM 0.453295806885367 0.318760618817651 no 1053 0.325167875893687 353 682214
SGTC_2241 6772625 37.8075 µM 0.452998546392296 0.318869912074179 no 1054 0.325274894115519 344 2285411
SGTC_3101 9120531 49.47 µM 0.451279964143624 0.319502088832984 no 1055 0.32589389170081 386 24824904
SGTC_615 k087-0205 167 µM 0.449457999448178 0.320172867900877 no 1056 0.326550649922652 359 9642773
SGTC_1843 st055809 45.5 µM 0.448468670892907 0.320537348113001 no 1057 0.326907495767759 341 16413835
SGTC_2085 5307070 144.047 µM 0.448263903292498 0.320612808529034 no 1058 0.326981374203432 383 2840351
SGTC_1325 1431-0015 227 µM 0.448251975669469 0.320617204293771 no 1059 0.326985677798991 337 1103340
SGTC_444 curcumin 90.4 µM 0.447609822101747 0.32085389846116 no 1060 0.327217406636703 357 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_280 3448-3607 3.04 µM 0.446670342372627 0.321200316578205 no 1061 0.327556549197796 357 626179
SGTC_715 0868-0130 184 µM 0.44468649575513 0.321932339325481 no 1062 0.32827316487648 354 2876258
SGTC_1683 st010134 710 nM 0.443351708390527 0.322425254038185 no 1063 0.328755679972023 349 3818134
SGTC_2059 5238311 157 µM 0.442014579773453 0.322919346532631 no 1064 0.329239327790756 344 703021
SGTC_3078 9116413 49.47 µM 0.441949842235392 0.322943276132287 no 1065 0.329262751027406 350 17177322
SGTC_3275 9138069 49.47 µM 0.439589553264195 0.323816233785407 no 1066 0.330117204159308 371 17617007
SGTC_1617 st002906 78 µM 0.438176409874848 0.324339352344655 no 1067 0.330629203900757 379 5150859
SGTC_3304 9125678 46.087 µM 0.437466665228537 0.3246022171212 no 1068 0.330886473060937 353 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_365 0121-0052 13.6 µM 0.436398064462757 0.324998154568554 no 1069 0.331273971514786 327 3101739
SGTC_2440 5628896 157.78 µM 0.43628365070917 0.325040558824403 no 1070 0.331315471210281 367 5522048
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.436051015530968 0.3251267855314 no 1071 0.331399858092149 373 165506
SGTC_853 0419-0306 21 µM 0.433685885181097 0.326003956926548 no 1072 0.332258278880749 359 762713
SGTC_2323 6148992 148.28 µM 0.433661301174522 0.32601307962724 no 1073 0.332267206244747 345 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_3049 9092223 49.47 µM 0.433595842825112 0.326037370599152 no 1074 0.332290977061726 364 8623917
SGTC_3298 9116858 71.43 µM 0.433156572740706 0.326200398651932 no 1075 0.332450512876629 387 2506942
SGTC_2014 4013930 200 µM 0.432166237457118 0.326568067550553 no 1076 0.332810298025261 383 64556
SGTC_525 k781-2675 26.7 µM 0.431944591940007 0.326650378090795 no 1077 0.332890842125248 365 3651118 YDL195W SEC31
SGTC_387 norethindrone acetate 66.7 µM 0.431068739010812 0.326975718392486 no 1078 0.333209195060748 380 541197
SGTC_2054 5233173 129 µM 0.431029797682429 0.326990186415531 no 1079 0.333223352154785 328 6889
SGTC_3136 9095672 49.47 µM 0.430983201727575 0.327007498733439 no 1080 0.333240292395466 339 17217380
SGTC_1098 clofazimine 15.1 µM 0.430853674400501 0.327055625430341 no 1081 0.333287384624317 366 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1674 st016616 23.6 µM 0.430643595399897 0.327133687725628 no 1082 0.33336376859951 352 625830
SGTC_484 loperamide 105 µM 0.43049897820972 0.327187429761399 no 1083 0.333416354910215 353 3955 An opioid-receptor agonist.
SGTC_3219 9131112 49.47 µM 0.429534976294368 0.327545759624234 no 1084 0.333766972946901 340 17612988 YMR079W SEC14
SGTC_2266 7929956 200 µM 0.428806800695133 0.32781653569213 no 1085 0.334031914659638 359 2967153
SGTC_2365 9042475 200 µM 0.42852767471425 0.32792035422663 no 1086 0.334133494682262 347 6464479
SGTC_304 1310-0298 97 µM 0.428464432660698 0.327943878418783 no 1087 0.334156511531351 385 1550234
SGTC_1720 st037298 9.481 µM 0.427621154578778 0.328257618379642 no 1088 0.334463480880104 389 597396
SGTC_1233 0325-0408 14.2 µM 0.427606583394201 0.328263040625972 no 1089 0.334468786043519 386 12874
SGTC_1357 1503-1303 39.5 µM 0.427364130000623 0.32835326797659 no 1090 0.334557064765127 340 292895
SGTC_308 4092-1169 104 µM 0.426533691497 0.328662385764271 no 1091 0.334859501657666 382 2268590 YDL196W YDL196W
SGTC_2772 vinpocetine 57.06 µM 0.426076548504097 0.328832600180413 no 1092 0.335026034021633 405 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2247 cerulenin 830 nM 0.424750176549309 0.329326667595528 no 1093 0.335509400820097 336 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1735 st034310 56.75 µM 0.424195760188582 0.329533273539647 no 1094 0.335711526314514 408 871153
SGTC_2236 dapsone 200 µM 0.424184191184004 0.329537585339827 no 1095 0.335715744573168 346 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1705 st027868 56.3335 µM 0.423346413650157 0.329849887566722 no 1096 0.336021267712897 393 292948
SGTC_1602 st001878 87.6 µM 0.422436298711759 0.330189289802462 no 1097 0.336353293881319 390 595405 YLR310C CDC25
SGTC_1979 st071809 45.3 µM 0.422182680435771 0.330283894650607 no 1098 0.336445841110343 393 4976333
SGTC_3173 9105693 49.47 µM 0.421267401663093 0.330625402708111 no 1099 0.336779915643565 371 17096658
SGTC_2841 9004761 38.96 µM 0.420966314454579 0.330737774964968 no 1100 0.33688983991769 328 2991039
SGTC_711 k292-0785 179 µM 0.419310913847524 0.331355878566912 no 1101 0.337494460704218 349 4146315
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.419303099293945 0.331358797504098 no 1102 0.337497315899162 382 23665772 A membrane-active detergent.
SGTC_2622 2-methoxyxanthone 59.94 µM 0.419081631382346 0.331441525736325 no 1103 0.337578237278342 358 71034 A hepatoprotective.
SGTC_1820 st053765 18.6 µM 0.418768070007524 0.331558669087201 no 1104 0.337692821207706 357 3690829
SGTC_1406 3909-7906 11.9 µM 0.418119937430532 0.331800857066138 no 1105 0.337929714318427 380 X1406
SGTC_188 3229-0966 278.469 µM 0.418079808347724 0.331815854430163 no 1106 0.337944383650241 372 5722370
SGTC_508 roscovitine 141 µM 0.416917536155266 0.332250345021262 no 1107 0.338369363180826 380 160355 A CDKinase inhibitor.
SGTC_1034 k072-0165 12.7 µM 0.416871267004766 0.332267646425576 no 1108 0.338386285551224 387 5835461
SGTC_363 0455-0021 3.06 µM 0.416220850134629 0.332510894354583 no 1109 0.338624202019578 377 4597466
SGTC_1669 st015249 58.4 µM 0.414257971355137 0.333245414304302 no 1110 0.339342595103233 375 722793
SGTC_765 1319-0117 244 µM 0.414094201266186 0.333306726930182 no 1111 0.339402559685851 357 3487746 YGL099W LSG1
SGTC_1513 0337-0559 19 µM 0.412226686139024 0.334006206244636 no 1112 0.340086639492606 354 775073
SGTC_1643 st009866 20.2 µM 0.410552880822204 0.334633621891884 no 1113 0.34070021021776 358 3156273 YOR207C RET1
SGTC_159 3970-0959 50 µM 0.409992812238299 0.334843663415359 no 1114 0.340905610115393 377 6615653
SGTC_1048 3161-0300 24.5 µM 0.409713047265938 0.334948602533201 no 1115 0.341008228963266 362 2165101
SGTC_1971 st069429 63.5 µM 0.40925509885616 0.335120405608929 no 1116 0.341176231552576 365 1246522 YGL099W LSG1
SGTC_576 1073-0113 22.7 µM 0.407049725511963 0.335948251969336 no 1117 0.341985733511279 391 5439563
SGTC_1753 st043925 64 µM 0.406996922789187 0.335968082674559 no 1118 0.342005124146532 365 670181
SGTC_2775 cyproheptadine 69.59 µM 0.405542678079319 0.336514421276554 no 1119 0.342539327064476 389 2913 A selective serotonin reuptake inhibitor.
SGTC_628 1636-0253 16 µM 0.404759276763111 0.336808876961158 no 1120 0.342827232733831 378 4456143
SGTC_3310 9130229 44.1445 µM 0.403594315879947 0.337246933763121 no 1121 0.343255533111709 391 7761258
SGTC_3155 9099265 49.47 µM 0.401088199840896 0.338190048761722 no 1122 0.344177594167551 402 25236499
SGTC_2366 9070441 60.58 µM 0.399684235087204 0.338718840836042 no 1123 0.344694552520648 360 6837235
SGTC_552 k242-0005 476 µM 0.399406240213802 0.338823583133869 no 1124 0.344796948345429 400 4088318
SGTC_36 0335-0881 14.2 µM 0.399313952975435 0.338858357672893 no 1125 0.344830943673058 363 23828853
SGTC_1508 1080-0625 72.9 µM 0.399313921625686 0.338858369485953 no 1126 0.344830955221401 369 767111
SGTC_2780 5215298 71.43 µM 0.399308495823602 0.338860414012555 no 1127 0.344832953932424 386 2834131
SGTC_65 0798-0905 34.986 µM 0.398342968999783 0.339224315069726 no 1128 0.345188695429579 406 3602145
SGTC_2826 7992541 19.48 µM 0.398051985211449 0.339334014484189 no 1129 0.345295933187268 419 2985066
SGTC_2934 9036370 36.88 µM 0.397658373769855 0.339482425672218 no 1130 0.345441012608236 389 6462800
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.397521267994222 0.339534127250621 no 1131 0.345491553125979 338 3256 An antibiotic and ribosome inhibitor.
SGTC_2028 5153890 36.43 µM 0.396893565572575 0.339770867762533 no 1132 0.345722974641515 383 2830968 YPR165W RHO1
SGTC_38 0929-0051 58.268 µM 0.396126560149094 0.340060232778675 no 1133 0.346005832697691 402 1379719
SGTC_1019 4262-0212 3.4 µM 0.395474120085625 0.340306450372318 no 1134 0.346246508732543 374 4677213
SGTC_1995 st072814 61.1 µM 0.395143454108005 0.340431262987367 no 1135 0.346368510517958 361 5769371
SGTC_2564 betulinic acid 100 µM 0.394556214347915 0.340652964583606 no 1136 0.346585216485235 370 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1266 0828-0227 32.9 µM 0.394538775905156 0.34065954898988 no 1137 0.346591652469131 359 3913820
SGTC_2991 9074669 71.4286 µM 0.393378354199691 0.341097809986276 no 1138 0.347020027263915 403 17333109
SGTC_2618 avocadyne 43.43 µM 0.3926595278336 0.341369399562715 no 1139 0.347285483326996 388 3015189
SGTC_935 2996-0153 430 µM 0.39126949911246 0.34189481823506 no 1140 0.34779902079742 380 23738523
SGTC_1775 st081588 35.1725 µM 0.391122295176861 0.341950477990047 no 1141 0.347853420750611 370 1426443 YGL099W LSG1
SGTC_175 3793-3120 23.7 µM 0.390063484773477 0.342350929358102 no 1142 0.348244801676331 400 5322297
SGTC_957 1187-1561 14.1 µM 0.389399459640299 0.34260215998032 no 1143 0.348490335850761 391 1538454
SGTC_1354 1498-1681 81 µM 0.388320815803853 0.343010407944906 no 1144 0.348889317389245 369 5754243
SGTC_1228 0124-0032 52.5 µM 0.387046134933343 0.343493088853494 no 1145 0.349361026874787 382 X1228
SGTC_3030 9087619 49.47 µM 0.385828697714011 0.343954331843195 no 1146 0.349811770069509 376 25236973
SGTC_174 3553-0389 74.3 µM 0.385179137522154 0.344200521825071 no 1147 0.350052349503659 357 738071
SGTC_2705 st078069 42.8 µM 0.385057993312871 0.344246444034382 no 1148 0.350097224688228 373 1530061
SGTC_1766 st045414 44.774 µM 0.384245125780346 0.344554637602428 no 1149 0.350398387551332 382 253960
SGTC_2701 st077767 14.721 µM 0.383129165216659 0.344977915061507 no 1150 0.350811997888011 378 5721188
SGTC_2947 9072639 7.68 µM 0.381775219234849 0.345491719556524 no 1151 0.351314050600595 358 16488146
SGTC_3125 9127534 49.47 µM 0.381579107649067 0.345566164931961 no 1152 0.351386791699688 367 1639235
SGTC_463 ikarugamyin 104 µM 0.381558747974206 0.345573893953997 no 1153 0.351394343758871 404 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1642 st009582 77.7 µM 0.380914714307261 0.345818417829294 no 1154 0.351633266856292 395 6739311
SGTC_3089 9117425 49.47 µM 0.379328965226638 0.346420762078437 no 1155 0.352221796473103 397 9401657
SGTC_2847 9005661 71.43 µM 0.378416511136052 0.346767532539386 no 1156 0.352560602222907 390 2991449
SGTC_2965 9082772 38.63 µM 0.378194007361448 0.346852112702526 no 1157 0.352643238443998 337 16459634
SGTC_2317 5986382 200 µM 0.377836904437091 0.346987873874311 no 1158 0.352775878307665 402 877883
SGTC_2276 7947513 42.08 µM 0.377402965839282 0.347152872392326 no 1159 0.352937081574687 378 2105100
SGTC_231 b-estradiol 524 µM 0.375178894560889 0.347998995776616 no 1160 0.353763712705207 360 450 A steroid.
SGTC_758 0868-0029 16 µM 0.375133077984969 0.348016434163357 no 1161 0.353780748835583 368 762687
SGTC_1075 aripiprazole 15.2 µM 0.37491201357928 0.348100578677525 no 1162 0.353862952065743 360 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.374575813781121 0.348228561912215 no 1163 0.353987981674954 404 279621
SGTC_1713 st033146 12.748 µM 0.373446269860802 0.348658678830609 no 1164 0.354408163910473 396 674619
SGTC_381 3461-2219 42.7 µM 0.371314052165237 0.349471132072699 no 1165 0.355201816404238 403 2883159
SGTC_3258 9138477 49.47 µM 0.370795964140389 0.349668646987279 no 1166 0.355394753789501 395 4970355
SGTC_1496 4469-0713 57.4 µM 0.369687499618395 0.350091372572716 no 1167 0.355807673420406 408 746691
SGTC_761 k216-0224 480 µM 0.368666419613186 0.350480937529527 no 1168 0.356188190776536 424 1340404
SGTC_1668 st014914 51.6 µM 0.368032649570537 0.350722814190327 no 1169 0.356424444645404 387 2839556
SGTC_3233 9132340 49.47 µM 0.366928620232475 0.351144308561637 no 1170 0.356836131177432 419 17682950
SGTC_684 1140-0066 328 µM 0.366803226557474 0.351192192731318 no 1171 0.35688290035335 368 6813534
SGTC_2739 tacrine 100.86 µM 0.366584091164814 0.351275879787382 no 1172 0.356964638361968 395 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2582 agaric acid 100 µM 0.365847333835705 0.351557297750199 no 1173 0.357239498682319 376 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_610 4215-0184 155 µM 0.365414175965941 0.351722788332691 no 1174 0.357401130463489 394 5605015
SGTC_490 phenamil 164 µM 0.365307317742466 0.351763618485371 no 1175 0.357441008279131 385 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2132 5317594 122.667 µM 0.364181003712952 0.352194083034916 no 1176 0.357861425637736 414 794577
SGTC_505 gw-5074 63.9 µM 0.362778125894604 0.352730512048362 no 1177 0.358385316659483 400 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1407 3909-7909 12.3 µM 0.361981713611471 0.353035172671636 no 1178 0.358682847782921 387 4411780
SGTC_2927 9011802 47.9 µM 0.361694491739128 0.353145070043905 no 1179 0.358790171863673 374 43912568
SGTC_1481 3346-2004 36 µM 0.361198363717619 0.353334928327927 no 1180 0.358975582625712 412 2770522
SGTC_497 capsazepine 133 µM 0.361017598288919 0.353404112722591 no 1181 0.359043145740532 362 2733484 A calcium channel blocker.
SGTC_721 1187-1332 279 µM 0.35990600913118 0.353829657905751 no 1182 0.359458711559206 388 25730
SGTC_2821 7996764 71.43 µM 0.359485481457948 0.353990694473326 no 1183 0.359615968531473 333 2987135
SGTC_2467 5474540 200 µM 0.358224408065842 0.354473765537215 no 1184 0.360087691324033 364 5413519
SGTC_385 1494-0393 12.4 µM 0.358067235196168 0.354533989139918 no 1185 0.360146499067124 397 3090647
SGTC_2858 9025781 8.96 µM 0.357658941410797 0.354690451214495 no 1186 0.360299281582684 388 4894980 YPL153C RAD53
SGTC_3118 9124250 49.47 µM 0.356401312165333 0.355172540706693 no 1187 0.360770023421092 410 1504786
SGTC_2384 9036245 200 µM 0.355391645480436 0.355559746093976 no 1188 0.361148103422928 387 6462766
SGTC_588 3970-1144 52.9 µM 0.355127631324962 0.35566101966487 no 1189 0.361246988612893 384 1888707
SGTC_885 0865-0106 16.8 µM 0.355094004657266 0.355673919298562 no 1190 0.361259583979967 377 2793380
SGTC_510 ag-490 170 µM 0.354214262066324 0.356011458859737 no 1191 0.361589158014378 379 5328779
SGTC_2482 5981709 142.65 µM 0.353844469395709 0.35615337459353 no 1192 0.361727722464996 398 877755
SGTC_2062 5245942 200 µM 0.35111667961388 0.357200835967543 no 1193 0.362750407540142 398 1376160
SGTC_2843 9000894 45.46 µM 0.350481774028948 0.357444792217259 no 1194 0.362988583018492 349 2242070
SGTC_2412 st077135 33.4 µM 0.350171423846073 0.357564062442395 no 1195 0.363105025610888 408 13258915
SGTC_3190 9110366 49.47 µM 0.348585286894362 0.358173845436563 no 1196 0.3637003375324 411 17123768
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.348096496067704 0.358361831830774 no 1197 0.363883857854835 367 115019
SGTC_2522 biochanin a 4.94 µM 0.346766158139936 0.358873646606757 no 1198 0.364383501636775 407 5280373 A possible chelator.
SGTC_1037 k284-1091 78.7 µM 0.345196458725286 0.359477875778515 no 1199 0.364973340430094 375 3334711
SGTC_549 1661-1316 519 µM 0.344813409520827 0.359625377488698 no 1200 0.365117325658129 406 2857282
SGTC_887 0885-0007 9.62 µM 0.344668059238289 0.359681353358567 no 1201 0.3651719666818 415 5719458
SGTC_793 0488-0545 106 µM 0.343408523095648 0.360166539470485 no 1202 0.365645574232681 397 292548
SGTC_925 2064-1272 59.6 µM 0.34280878056672 0.360397645621469 no 1203 0.365871159931253 398 6815817
SGTC_2883 9059145 45.46 µM 0.342068049775798 0.360683150915084 no 1204 0.366149840626991 423 16476510
SGTC_1913 st060213 96.1 µM 0.341811394979522 0.360782093379413 no 1205 0.366246416799977 421 688959
SGTC_3264 9137442 49.47 µM 0.341498195182218 0.360902847015537 no 1206 0.366364281667839 377 17015726
SGTC_3251 9135047 49.47 µM 0.340767267479087 0.36118470884124 no 1207 0.366639396953517 403 17682963
SGTC_2292 7671323 168.05 µM 0.340343285060008 0.361348240357695 no 1208 0.366799011927412 425 937504
SGTC_1119 parthenolide 318.541 nM 0.34002663614916 0.361470389490142 no 1209 0.366918234509381 414 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1880 MG-132 525 µM 0.340026004246791 0.361470633264224 no 1210 0.366918472441976 428 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1998 st075797 76.8 µM 0.339733601976586 0.36158344168291 no 1211 0.367028577261326 419 24208315
SGTC_1680 diphenhydramine 100 µM 0.33922765276728 0.361778664652523 no 1212 0.367219119557401 420 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_3144 9087057 49.47 µM 0.338279121425597 0.362144757012468 no 1213 0.367576427979845 432 17249618
SGTC_1161 k007-0610 110 µM 0.337490935446235 0.362449058926049 no 1214 0.367873422109779 398 5843850
SGTC_1667 st014849 34.6 µM 0.337183153987959 0.362567910438332 no 1215 0.367989417830779 389 5348460
SGTC_173 1273-0061 2.693 µM 0.336778181851396 0.362724312845654 no 1216 0.368142060812461 403 2847414 YPL266W DIM1
SGTC_918 glabranin 770.725 nM 0.336410308252213 0.362866407454864 no 1217 0.368280738579283 402 124049 Also referred to as licorice root.
SGTC_1229 0139-0193 12.2 µM 0.335002025006823 0.363410544356577 no 1218 0.368811779330934 400 3090752
SGTC_1689 st020265 53.493 µM 0.334906137962322 0.363447603531647 no 1219 0.368847945901495 411 5758320 YPR016C TIF6
SGTC_193 1273-0060 1.558 µM 0.334460898756487 0.363619699802468 no 1220 0.369015895950808 393 2847393 YHR072W ERG7
SGTC_3107 9121808 49.47 µM 0.33273750212576 0.364286095570634 no 1221 0.36966621920365 360 662681
SGTC_2629 bisabolol 100 µM 0.33138578454658 0.364809059401158 no 1222 0.370176550581505 432 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1250 0485-0349 40.2 µM 0.330380089043957 0.365198314626262 no 1223 0.370556392170176 394 6842794 YDL195W SEC31
SGTC_2382 9035899 200 µM 0.330019616057383 0.365337869818847 no 1224 0.370692570123583 435 6462679
SGTC_2033 5192550 145 µM 0.329838835122047 0.365407864908175 no 1225 0.370760870878187 375 182073
SGTC_2552 juarezic acid 87.02 µM 0.329264554639552 0.365630245592848 no 1226 0.37097786650864 375 1549512
SGTC_2114 5491910 81.25 µM 0.327497937629326 0.366314621918346 no 1227 0.37164565128626 434 2849228
SGTC_1539 benzyladenosine 56 µM 0.326606544851376 0.366660103498568 no 1228 0.371982746361029 359 92208 A nucleotide analog.
SGTC_2013 4024628 200 µM 0.326047800577997 0.366876713938479 no 1229 0.372194094905514 403 5230760
SGTC_1957 st077035 62.4 µM 0.325789446788552 0.366976885235768 no 1230 0.372291831877608 416 705593
SGTC_3208 9114115 49.47 µM 0.324175742874641 0.367602770020401 no 1231 0.372902492836453 425 650895
SGTC_828 2074-0507 139 µM 0.323453736599525 0.367882918522818 no 1232 0.373175819400245 387 X828
SGTC_1787 fluconazole 80 µM 0.323417222497009 0.367897088372358 no 1233 0.373189644071503 394 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1177 0983-0204 23.6 µM 0.323026164309538 0.368048855683609 no 1234 0.373337713562231 399 766818
SGTC_336 4111-0029 111 µM 0.322795920881893 0.368138221397195 no 1235 0.373424901223736 415 3131175
SGTC_1300 1094-0077 113 µM 0.322121109878968 0.36840018078528 no 1236 0.373680473271883 394 5532636
SGTC_1282 0886-0010 32.4 µM 0.319095673344524 0.369575395682588 no 1237 0.374826982238566 428 2836211 YNL267W PIK1
SGTC_2508 celastrol 40.54 µM 0.318871787328385 0.369662411622468 no 1238 0.374911869430442 359 122724 Celastrol is a natural product and antioxidant.
SGTC_1719 st032227 49.2 µM 0.31857092831963 0.369779354535227 no 1239 0.375025950753815 390 3125804
SGTC_2270 7924575 90.91 µM 0.318401288387261 0.369845298333112 no 1240 0.375090280549608 406 1262135
SGTC_590 k048-0076 22.4 µM 0.316971059484367 0.370401420397885 no 1241 0.375632781002375 414 6832814
SGTC_1144 3486-0183 12.5 µM 0.316154925476045 0.37071888280694 no 1242 0.375942459280192 441 6744069
SGTC_122 0236-0016 402.397 µM 0.315290226409248 0.371055332257961 no 1243 0.376270652530617 412 6808838
SGTC_1965 Pectolinarigenin 58.4 µM 0.31439255871274 0.371404713913465 no 1244 0.376611453567244 392 5320438 An anti-inflammatory.
SGTC_2040 5100729 123 µM 0.314012020362642 0.371552855423012 no 1245 0.376755954632986 397 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1485 3909-9022 254 µM 0.31318903960384 0.371873302397422 no 1246 0.377068522498802 403 714516
SGTC_1831 st055328 12 µM 0.312811001335703 0.372020530286947 no 1247 0.377212128347369 414 1103068
SGTC_1187 1391-0724 117 µM 0.312497627090892 0.372142588808085 no 1248 0.377331183070973 400 6997986
SGTC_2941 9056145 11.23 µM 0.310464845381105 0.372934663914011 no 1249 0.378103744453719 443 2119517
SGTC_2760 etidronate 98.04 µM 0.30896813513121 0.37351820208069 no 1250 0.378672883083531 410 3305 A chelator and antioxidant.
SGTC_2221 6807166 181.081 µM 0.308751001070589 0.373602882550519 no 1251 0.37875547231499 409 674925
SGTC_1884 5633444 25 µM 0.307381953243614 0.374136940161666 no 1252 0.3792763314752 401 5724239
SGTC_3021 9087658 49.47 µM 0.306866470664236 0.374338089603112 no 1253 0.379472505534978 430 25237042
SGTC_1193 1488-0126 41.5 µM 0.306358933594348 0.374536172005484 no 1254 0.379665686141202 395 1384710
SGTC_809 3998-0021 90 µM 0.306329312992324 0.374547733405968 no 1255 0.379676961370696 440 715485
SGTC_287 k060-0039 29.6 µM 0.305766280897215 0.374767515383293 no 1256 0.379891301782732 397 5861974
SGTC_83 0170-0301 39.027 µM 0.305557894087989 0.374848870381092 no 1257 0.379970641814993 409 3089716
SGTC_2738 aclarubicin 5.55 µM 0.304760363476035 0.375160280764931 no 1258 0.380274335814726 411 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_93 0109-0045 59.227 µM 0.304520848780519 0.375253819550268 no 1259 0.380365555734271 415 88733
SGTC_2136 5328288 199.296 µM 0.303649806326464 0.375594053612618 no 1260 0.380697351034203 400 262395
SGTC_2600 tangeritin 87.95 µM 0.302902375544838 0.375886081420976 no 1261 0.380982130464868 405 68077 A bioactive flavone.
SGTC_1591 genipin 88.4 µM 0.302244668664587 0.37614311212388 no 1262 0.381232777431997 402 442424 A DNA cross-linking agent.
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.30143014607081 0.376461502285352 no 1263 0.381543254703345 417 756377
SGTC_3090 9117696 49.47 µM 0.301362084349428 0.376488110859582 no 1264 0.381569201719494 429 7923821
SGTC_3340 9146634 11.102 µM 0.301028012674109 0.376618723924682 no 1265 0.381696566824002 428 4907387
SGTC_3055 9094636 49.47 µM 0.299949877179271 0.377040342272633 no 1266 0.382107694187866 418 25236176
SGTC_151 3013-0144 2.285 µM 0.298385559971249 0.377652348693151 no 1267 0.38270445443164 441 906558 YHR107C CDC12
SGTC_2605 digitonin 300 nM 0.298216051365258 0.377718683873242 no 1268 0.382769135818653 404 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_443 clozapine 122 µM 0.297894877842887 0.377844381206483 no 1269 0.382891698732197 450 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3211 9128781 49.47 µM 0.297427571672674 0.378027293414747 no 1270 0.383070048214612 422 17194361
SGTC_1846 st056244 14.8 µM 0.294937929401859 0.379002245078109 no 1271 0.384020648280154 423 5393182
SGTC_2164 5685496 200 µM 0.294340442024888 0.379236337840663 no 1272 0.384248886175472 382 759046
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.294039591973096 0.379354226255438 no 1273 0.38436382494574 415 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1583 clindamycin 39.6 µM 0.293188364114874 0.37968784154729 no 1274 0.384689088796477 428 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_703 3875-0075 71.8 µM 0.292819370564688 0.379832486242953 no 1275 0.38483011066767 432 2850814
SGTC_584 0986-0246 15.4 µM 0.292576436515319 0.379927725059628 no 1276 0.38492296346715 446 53315 YDR232W HEM1
SGTC_2176 5809774 33.9695 µM 0.292173071347217 0.380085874682277 no 1277 0.385077149863776 438 2870539
SGTC_2708 st078559 56 µM 0.291959683228189 0.380169547059543 no 1278 0.38515872485569 420 17250902
SGTC_56 0957-0365 83.25 µM 0.291562469598502 0.380325314847898 no 1279 0.385310587042511 416 6752360
SGTC_3333 9141820 12.094 µM 0.290758451821601 0.38064067073874 no 1280 0.385618031859658 440 1939433
SGTC_3120 9124077 49.47 µM 0.289549862020299 0.381114859085861 no 1281 0.386080314370314 440 18774327 YGL155W CDC43
SGTC_1679 SEC14.276 6.7 µM 0.288854026547001 0.381387950111149 no 1282 0.386346543095777 444 1005053 YMR079W SEC14
SGTC_1687 st020778 55.3625 µM 0.288794221868631 0.381411424108827 no 1283 0.386369427043016 425 4259299
SGTC_1594 piperine 70.1 µM 0.288361958440419 0.381581105252034 no 1284 0.386534842129828 414 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_488 nitrendipine 139 µM 0.287532371299713 0.381906815994943 no 1285 0.38685235959074 407 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2488 5268135 45.7 µM 0.287042661133317 0.382099124222507 no 1286 0.3870398275821 422 1270356 YLR208W SEC13
SGTC_3123 9126162 49.47 µM 0.286507911959826 0.382309152407142 no 1287 0.3872445672431 375 25239884
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.286233593981818 0.382416907030051 no 1288 0.387349607670304 440 1241132 A phosphatase inhibitor.
SGTC_3113 9123498 49.47 µM 0.285716015078118 0.382620241571589 no 1289 0.387547818774705 439 8897275
SGTC_473 2-arachidonoylglycerol 10 µM 0.28494460113896 0.382923357051977 no 1290 0.387843292485349 409 5282280 An endocannabinoid.
SGTC_1399 3562-5772 25 µM 0.282991390240393 0.383691162108953 no 1291 0.388591718475479 397 23847490
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.282836576893873 0.383752038646123 no 1292 0.388651057162017 450 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2925 9010536 32.5 µM 0.282405609669193 0.383921521003616 no 1293 0.388816257046342 393 2994177
SGTC_1622 st003707 19.4 µM 0.282368503249988 0.38393611452873 no 1294 0.388830481751048 424 10140899
SGTC_1291 0993-0025 5.79 µM 0.281372470094558 0.384327904278325 no 1295 0.389212365594918 426 4353356
SGTC_2291 7917025 104.35 µM 0.281207639060008 0.384392751993622 no 1296 0.389275572928654 408 2964612
SGTC_1244 0416-0015 52.5 µM 0.281065312220124 0.384448748726934 no 1297 0.389330152993815 427 96201
SGTC_1495 4469-0029 237 µM 0.281011510930732 0.384469916806346 no 1298 0.389350785495942 413 793680
SGTC_1197 1601-0112 267 µM 0.279275615901534 0.385153088027162 no 1299 0.390016658900597 429 7350313
SGTC_221 trifluoperazine 10.304 µM 0.27857706991352 0.385428105464462 no 1300 0.390284705946746 446 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2750 bromebric acid 70.15 µM 0.277494659101005 0.385854364191717 no 1301 0.390700153141164 407 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2159 5658611 73.75 µM 0.276169781817698 0.386376295016764 no 1302 0.391208832806822 435 793844
SGTC_1377 2944-0135 198 µM 0.274415404661886 0.387067742161815 no 1303 0.391882703011874 391 1894137
SGTC_2628 lathosterol 100 µM 0.274403581220933 0.387072403316054 no 1304 0.391887245592472 399 6710616
SGTC_625 k213-0058 121 µM 0.270645767751014 0.388554667518402 no 1305 0.393331745731693 420 3655420
SGTC_2083 5306046 65.942 µM 0.270278556613574 0.388699600894189 no 1306 0.393472980504349 396 539837
SGTC_47 0149-0135 24.25 µM 0.270203054795277 0.388729402383588 no 1307 0.393502021345634 408 5239155
SGTC_2818 7996756 12.99 µM 0.269966698013644 0.388822699523689 no 1308 0.393592936890247 444 2241621
SGTC_3127 9126946 49.47 µM 0.269313569042283 0.389080542525528 no 1309 0.393844195610237 440 27243249
SGTC_1107 amlodipine 47 µM 0.268898592039448 0.389244393010576 no 1310 0.39400386023541 416 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_832 4083-0019 164 µM 0.268555998356811 0.389379678340447 no 1311 0.394135688418165 400 1990758
SGTC_868 0527-0199 213 µM 0.268065372726003 0.389573442709629 no 1312 0.394324499607926 423 2849450
SGTC_1903 st060211 78.3 µM 0.265464943802457 0.390600895811662 no 1313 0.395325656058371 413 688960
SGTC_1319 1306-0155 43.7 µM 0.26415462784444 0.39111890362565 no 1314 0.395830385671014 418 3122360
SGTC_3062 9077494 49.47 µM 0.262460033497032 0.391789114799328 no 1315 0.396483397111073 400 16459633
SGTC_3139 9095020 49.47 µM 0.262126522529187 0.391921056109961 no 1316 0.396611949733369 448 25236292
SGTC_690 glyoxal 20.3 µM 0.261659623925889 0.392105788196225 no 1317 0.396791935824781 418 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2557 derrustone 83.84 µM 0.26131488753144 0.392242201459784 no 1318 0.396924843367725 445 629853 An antioxidant.
SGTC_2523 spermine 47.74 µM 0.261024352100793 0.392357177518112 no 1319 0.397036863903718 423 1103 A DNA binding polyamine.
SGTC_3002 9075603 71.4286 µM 0.260269431451169 0.392655972598507 no 1320 0.397327975209303 436 20105405
SGTC_860 0443-0016 25.1 µM 0.259936697837016 0.392787687556746 no 1321 0.397456301590636 411 5337942
SGTC_2464 5717415 7.67 µM 0.259685905193007 0.392886973717305 no 1322 0.397553032886263 400 5285744
SGTC_1365 1672-3266 55.4 µM 0.259157454075728 0.393096204743785 no 1323 0.397756878305898 457 6415873
SGTC_2507 purpurin 79.67 µM 0.258950860483084 0.393178010283531 no 1324 0.397836577580154 410 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2434 5670830 169.91 µM 0.258282453236273 0.393442713986243 no 1325 0.39809446362495 436 1549830
SGTC_1264 0783-0040 158 µM 0.257670713732649 0.393685019215152 no 1326 0.398330525047841 436 2855798
SGTC_68 0986-0284 82.829 µM 0.257614110159004 0.393707441530062 no 1327 0.398352369430071 382 423278 YIL048W NEO1
SGTC_1009 4106-0057 9.87 µM 0.257143516725094 0.393893870857432 no 1328 0.398533992601677 450 2928005
SGTC_1500 4488-1866 171 µM 0.255368764911357 0.394597171355639 no 1329 0.399219146586394 461 2900003
SGTC_2540 epiandrosterone 100 µM 0.25476678757431 0.394835801735408 no 1330 0.399451614327144 422 441302 A steroid.
SGTC_2007 4011539 71.82 µM 0.253720361145209 0.395250710444771 no 1331 0.39985580137644 424 45595301
SGTC_198 3454-2873 16.191 µM 0.253395882661642 0.395379390507541 no 1332 0.399981154510859 438 710957
SGTC_74 000s-0487 160.283 µM 0.252732397590658 0.3956425476147 no 1333 0.400237505376043 357 677548
SGTC_2029 5175081 200 µM 0.251308823215211 0.3962073382556 no 1334 0.400787677040836 405 1380876
SGTC_2260 7964312 200 µM 0.250693165264268 0.396451662716043 no 1335 0.401025672653022 412 231951
SGTC_870 0573-2213 57.6 µM 0.250435553192015 0.396553908393264 no 1336 0.40112526895873 410 3916321
SGTC_57 miconazole 162.5 nM 0.24889199106535 0.397166693660114 no 1337 0.401722165301309 443 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2670 beta-carotene 100 µM 0.247399289019069 0.397759529328514 no 1338 0.4022996121844 420 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1836 st055642 81 µM 0.244437189126712 0.398936643379861 no 1339 0.403446121184182 456 8571
SGTC_1375 2910-0797 186 µM 0.243475203943622 0.399319126725736 no 1340 0.403818645817732 461 742508
SGTC_1882 5615643 20 µM 0.242950044678447 0.399527969791146 no 1341 0.404022048331951 431 2253075
SGTC_2989 9073649 71.4286 µM 0.242605280130149 0.399665089902882 no 1342 0.40415559522578 458 21367202
SGTC_14 0354-0009 295 µM 0.242107543735526 0.399863071961144 no 1343 0.404348416506004 474 1713507
SGTC_1459 k035-0031 35.7 µM 0.241328828261773 0.400172869259128 no 1344 0.404650134665803 411 3877128 YMR208W ERG12
SGTC_2968 9090663 33.37 µM 0.240756536055932 0.4004005850099 no 1345 0.404871909005477 462 25236811
SGTC_1856 st057054 55.7 µM 0.240324847993903 0.400572376612467 no 1346 0.40503921673291 448 1266018
SGTC_1892 st058411 7.36 µM 0.239953102548193 0.400720329280112 no 1347 0.405183306636027 450 3934738
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.238324556361961 0.401368649421317 no 1348 0.405814688377549 456 6710655
SGTC_344 k064-0035 6.43 µM 0.237808173343951 0.401574277006481 no 1349 0.406014939548298 444 5088750
SGTC_2481 5478948 45.16 µM 0.236978996750741 0.401904518336795 no 1350 0.406336542184577 411 77792
SGTC_3032 9089427 49.47 µM 0.236473253033009 0.402105978449124 no 1351 0.406532729890047 459 17173707
SGTC_396 dithiazanine 1.25 µM 0.235640488388252 0.402437762125747 no 1352 0.40685582640269 421 10578 An antihelmenthic.
SGTC_23 0213-0011 39.996 µM 0.234765707361739 0.402786361344426 no 1353 0.407195292739768 428 627608
SGTC_248 streptozotocin 5.23457 mM 0.234301144894428 0.402971520388516 no 1354 0.407375598580902 444 5300 DNA alkylating agent.
SGTC_1348 1493-0373 93.8 µM 0.234296268594984 0.402973464033672 no 1355 0.407377491272887 452 3010129
SGTC_2202 7226349 200 µM 0.233809546580378 0.403167478712302 no 1356 0.407566418939203 417 844334
SGTC_3029 9088683 49.47 µM 0.233349050370344 0.403351061341363 no 1357 0.407745186503698 417 25236615
SGTC_2572 astragaloside iv 100 µM 0.232762634392147 0.403584874305743 no 1358 0.407972864728761 415 45006101 An anti-inflammatory agent.
SGTC_1395 3486-0190 4.35 µM 0.232582484330926 0.403656709797164 no 1359 0.408042814916332 450 6748079
SGTC_2877 9040724 71.43 µM 0.23227596795351 0.403778941784508 no 1360 0.408161838419368 427 6463895
SGTC_792 4534-1957 155 µM 0.231494556744436 0.404090593871701 no 1361 0.408465306848559 422 1717904
SGTC_1164 k060-0068 93.7 µM 0.230470441100184 0.404499136503713 no 1362 0.408863114937771 424 5963676
SGTC_1421 4029-0249 71.4 µM 0.229973564954535 0.404697389060858 no 1363 0.409056155660034 447 2894095
SGTC_1260 0700-1617 7.75 µM 0.229544052620049 0.404868783315374 no 1364 0.409223042731292 441 2853078
SGTC_137 0438-0332 85.389 µM 0.228130034250998 0.405433167428755 no 1365 0.409772575842409 458 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1877 wortmannin 25 µM 0.225978878956171 0.406292145478528 no 1366 0.410608923800269 463 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2319 6033012 152.6 µM 0.225743472164555 0.406386173253435 no 1367 0.410700472390773 422 847246
SGTC_1859 st055998 20 µM 0.22525681739761 0.4065805733066 no 1368 0.41088974555293 437 676301
SGTC_2417 cerulenin 830 nM 0.224495641697325 0.406884680177665 no 1369 0.411185828901168 474 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1754 st042065 16.137 µM 0.222321404405489 0.407753645730842 no 1370 0.41203184535397 441 1126236 YIL048W NEO1
SGTC_360 0957-0399 1.01 µM 0.221230363165945 0.408189867577774 no 1371 0.412456534267697 437 6752301 YPR165W RHO1
SGTC_2829 7992743 58.44 µM 0.22120913488801 0.40819835623215 no 1372 0.412464798414831 446 16462845
SGTC_2058 5236698 133 µM 0.22043172971523 0.408509250653078 no 1373 0.412767468166774 416 766665
SGTC_1745 st081495 74 µM 0.219736215654131 0.4087874445711 no 1374 0.413038298946967 449 13842402 YBL026W LSM2
SGTC_622 1348-1566 26.3 µM 0.217824971351915 0.409552146401133 no 1375 0.413782743686096 450 7340407
SGTC_3092 9117248 49.47 µM 0.217169232110516 0.409814591587742 no 1376 0.414038230849461 465 17141857
SGTC_923 1900-2434 73.3 µM 0.216844780133733 0.409944461295525 no 1377 0.414164656320909 484 5910570
SGTC_1784 st039334 36.3 µM 0.216722233766193 0.409993515997957 no 1378 0.414212409869999 449 3496984
SGTC_2253 7938677 135.83 µM 0.216267882642795 0.410175402784034 no 1379 0.414389471294271 434 2301972
SGTC_3343 9148379 18.9835 µM 0.215953226445854 0.41030137793557 no 1380 0.414512103561683 451 1955036
SGTC_2259 7964009 200 µM 0.215743283724591 0.410385435349948 no 1381 0.414593930046629 418 313134
SGTC_1356 1502-0781 85.8 µM 0.215679429482752 0.410411002294551 no 1382 0.414618818370849 424 567702
SGTC_3170 9103054 49.47 µM 0.214446987215371 0.410904540975113 no 1383 0.415099251657656 454 16432970
SGTC_1848 st056003 16.4 µM 0.212824988452995 0.411554294723208 no 1384 0.415731736127176 462 146492
SGTC_1326 1431-2094 10.8 µM 0.212166748929509 0.411818047096869 no 1385 0.415988473350635 470 616278
SGTC_2166 5933061 31.504 µM 0.211940779464201 0.411908600811864 no 1386 0.416076617888797 441 2877375
SGTC_3223 9129970 49.47 µM 0.211547240534705 0.412066316555026 no 1387 0.416230136789657 431 17248386
SGTC_2681 menadione 3.18 µM 0.211514610123995 0.412079394246148 no 1388 0.416242866434309 456 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_189 3970-0742 2.116 µM 0.21107449820886 0.41225579284659 no 1389 0.416414569704198 472 2891807
SGTC_2840 9008771 71.43 µM 0.210456199849974 0.412503639219246 no 1390 0.416655816765189 448 2992978
SGTC_2671 danthron 100 µM 0.210224999489975 0.412596325403639 no 1391 0.416746034369216 437 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1185 1319-0113 81.3 µM 0.207334926547756 0.413755339782131 no 1392 0.417874149640594 451 4672763
SGTC_1094 duloxetine 25.4 µM 0.206718302987646 0.414002723772882 no 1393 0.418114931208787 447 60834 A selective serotonin reuptake inhibitor.
SGTC_1568 digitonin 820 nM 0.205862148695252 0.414346261972873 no 1394 0.41844929654525 455 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2351 9026858 72.31 µM 0.205690256482219 0.414415242894639 no 1395 0.418516435012009 448 1409300
SGTC_2502 avocadyne acetate 18.59 µM 0.205553894017141 0.414469967487196 no 1396 0.418569697791805 411 3952079
SGTC_1248 0469-0687 58.6 µM 0.204514818596148 0.41488702070083 no 1397 0.418975606573413 441 4017482
SGTC_1741 st038134 10.228 µM 0.203370348937682 0.415346486970577 no 1398 0.419422786822018 456 1272587
SGTC_3052 9092717 49.47 µM 0.203316936271592 0.415367933201409 no 1399 0.41944365937536 445 25237534
SGTC_2799 7812892 81.82 µM 0.202761884890926 0.415590812106974 no 1400 0.41966057525796 458 20205235
SGTC_1885 st057546 99.9 µM 0.202445201059537 0.415717987544441 no 1401 0.419784347270386 423 702008
SGTC_1476 4112-3294 3.34 µM 0.201919703072785 0.415929039061018 no 1402 0.419989749251582 466 704369
SGTC_3242 9133940 49.47 µM 0.200359845302153 0.416555654743625 no 1403 0.420599580751003 446 17248444
SGTC_2759 disulfiram 3.38 µM 0.200045807876692 0.416681833468645 no 1404 0.420722377807451 431 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.19992439061996 0.416730620639517 no 1405 0.420769857280081 475 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_983 1491-0821 12.2 µM 0.199455268647208 0.416919132527073 no 1406 0.420953315369969 435 46495113
SGTC_1352 1496-0991 99 µM 0.198847465460964 0.417163400452564 no 1407 0.421191032619741 486 3000039
SGTC_1353 1498-1206 8.11 µM 0.198794067509219 0.417184861900585 no 1408 0.421211918409387 460 6756808
SGTC_1860 st056228 74.6 µM 0.197294587003856 0.417787626420658 no 1409 0.42179850752208 482 688679
SGTC_607 4491-0986 66.8 µM 0.194644949887165 0.418853204932813 no 1410 0.422835455543456 446 698981 YDR232W HEM1
SGTC_962 1254-0300 21.5 µM 0.193730407758057 0.419221136017327 no 1411 0.423193490469578 447 7340576
SGTC_3325 9138760 55.175 µM 0.19330598992102 0.419391908339542 no 1412 0.423359667762425 426 43844959
SGTC_2958 9077254 16.72 µM 0.19163511837028 0.420064361502593 no 1413 0.424014015915274 433 16457351
SGTC_1633 st005664 67.9 µM 0.187270981190903 0.421821833263034 no 1414 0.425724087059519 441 2063822
SGTC_1810 st050138 53 µM 0.186865807581215 0.421985079389071 no 1415 0.425882924264435 485 3444541
SGTC_2099 5377090 177.372 µM 0.186805973913736 0.422009187758261 no 1416 0.425906381433037 449 2243829
SGTC_2134 5324836 1.464 µM 0.186657783015944 0.42206889855825 no 1417 0.425964479265796 485 699272
SGTC_1943 st076331 65.2 µM 0.186338176509744 0.422197684225068 no 1418 0.426089785584028 483 24208415
SGTC_759 3486-0358 89.3 µM 0.185285588108319 0.422621884206381 no 1419 0.426502520669784 474 875103
SGTC_3319 9138450 16.7555 µM 0.183557667450018 0.423318441869247 no 1420 0.427180237611857 474 2029690
SGTC_2403 6032726 181.2 µM 0.183114995820432 0.423496929880547 no 1421 0.4273538948753 452 2881040
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.182905528273372 0.423581393999559 no 1422 0.427436072569715 459 688803
SGTC_1307 1187-1599 12.2 µM 0.182627065391206 0.423693684715098 no 1423 0.4275453231862 467 1538471
SGTC_145 3737-0113 38.366 µM 0.18231061035383 0.423821303365602 no 1424 0.427669486183138 456 6849351
SGTC_924 2046-0044 21.3 µM 0.180946730336598 0.42437141439757 no 1425 0.428204694353946 457 3623589
SGTC_730 1436-0052 41.2 µM 0.180871675753815 0.424401691402316 no 1426 0.428234150807321 438 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1832 st054113 55 µM 0.179542383342658 0.424938001471266 no 1427 0.428755920436348 475 1251267
SGTC_2160 5660466 132.927 µM 0.177079717024077 0.425931943727812 no 1428 0.429722886807261 477 2859134
SGTC_448 monastrol 171 µM 0.176712349969412 0.426080255085684 no 1429 0.429867169837053 473 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1945 st075991 56.6 µM 0.175556985522219 0.426546760368918 no 1430 0.430320998990938 409 1084980
SGTC_1776 st049249 45.9 µM 0.174376280979304 0.427023603489957 no 1431 0.430784876885194 466 1822314
SGTC_2302 7771753 200 µM 0.174288712965466 0.427058973245692 no 1432 0.43081928461866 463 2203047
SGTC_2520 obtusaquinone 4.71 µM 0.173835202306924 0.427242160937221 no 1433 0.430997489061781 491 5967872
SGTC_124 0136-0217 7.121 µM 0.173755858682924 0.427274212018909 no 1434 0.431028668134207 447 3976905
SGTC_897 1000-0139 31.4 µM 0.172443752801432 0.427804310360739 no 1435 0.431544338788301 479 6151020
SGTC_781 4335-2806 94.4 µM 0.170156752421287 0.428728582738665 no 1436 0.43244343111383 484 845254
SGTC_1574 spiramycin 23.7 µM 0.170023771555049 0.428782337938684 no 1437 0.432495720916397 472 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2423 st077119 87.2 µM 0.169318285553138 0.429067540444864 no 1438 0.432773146920962 455 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_357 1325-0123 420 µM 0.168713170409931 0.429312196151807 no 1439 0.43301112939991 475 1098503
SGTC_1050 3232-1156 69.3 µM 0.168318935770256 0.429471604818695 no 1440 0.433166188896872 483 700529
SGTC_2783 7738165 71.43 µM 0.166297294675397 0.430289234991065 no 1441 0.433961497470532 484 17201110
SGTC_171 k064-0041 9.68 µM 0.165466691718391 0.430625249940731 no 1442 0.434288332292697 444 53325
SGTC_1964 st076914 61 µM 0.165261422154138 0.430708298140086 no 1443 0.434369110958402 490 24208661
SGTC_1329 1447-1697 50.6 µM 0.165225167864345 0.430722966261391 no 1444 0.434383378205633 457 2840515
SGTC_1503 4585-0012 61.3 µM 0.163991256693042 0.431222251171899 no 1445 0.434869013389148 460 2922052
SGTC_1443 4112-3303 14 µM 0.163739102345941 0.431324295457303 no 1446 0.434968266866396 480 704433
SGTC_2703 st077852 53.4 µM 0.161628124334175 0.432178765850478 no 1447 0.435799354245587 461 6281836
SGTC_178 4092-0806 87.505 µM 0.161444881878339 0.432252952777925 no 1448 0.4358715098252 467 2169044
SGTC_1455 4262-0120 131 µM 0.161299503871821 0.432311811730587 no 1449 0.435928756998432 447 1529587
SGTC_1609 st001574 46.4 µM 0.160950977453213 0.432452925159633 no 1450 0.43606600572803 501 3960012
SGTC_798 1287-0182 476 µM 0.158007218915553 0.433645153440958 no 1451 0.437225555152608 491 1649755
SGTC_1936 st074407 74.3 µM 0.157131303772375 0.434000017970119 no 1452 0.437570683585596 474 809813
SGTC_3240 9133527 49.47 µM 0.155882379526793 0.434506093754796 no 1453 0.438062867306807 480 17617455
SGTC_2430 5571206 200 µM 0.155561196738956 0.434636257409012 no 1454 0.438189456509404 495 1731771
SGTC_2117 5521686 200 µM 0.15174408457816 0.436183732192149 no 1455 0.439694392648661 457 803312
SGTC_613 3914-0030 117 µM 0.151316956421947 0.436356953143467 no 1456 0.439862847001472 486 1145395
SGTC_1055 3448-0672 86 µM 0.150803504194106 0.436565198799041 no 1457 0.440065360967472 470 748378
SGTC_1452 4194-0072 190 µM 0.150697181024328 0.436608323487593 no 1458 0.440107298528123 472 1343545
SGTC_1826 st055655 41.6 µM 0.149229682747263 0.43720361768354 no 1459 0.440686199390792 491 676168
SGTC_343 4130-2827 29.8 µM 0.145216207362211 0.438832415964965 no 1460 0.442270084973959 443 1118244
SGTC_2603 homopterocarpin 100 µM 0.144095411712471 0.439287457442641 no 1461 0.442712563917262 464 101795 A weak amylase inhibitor.
SGTC_2658 polymyxin b sulfate 77.05 µM 0.141962364493258 0.440153692829256 no 1462 0.443554866663206 468 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_550 4123-0385 25.7 µM 0.140917870915906 0.440577968840037 no 1463 0.443967412038633 472 5731123
SGTC_2756 carbadox 75.1 µM 0.140652297644282 0.440685856292756 no 1464 0.444072315658493 478 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_834 0312-0008 75.7 µM 0.140200981148427 0.440869210843881 no 1465 0.444250598359081 474 6385573 YIL048W NEO1
SGTC_209 4077-0173 175.592 µM 0.139799846738702 0.441032188761325 no 1466 0.444409067195726 485 15993494
SGTC_1180 1193-0155 285 µM 0.139617806091338 0.441106153814239 no 1467 0.444480985598868 471 2921347
SGTC_1427 4048-4900 550 nM 0.139444643839591 0.441176513387016 no 1468 0.444549398129932 486 24132586
SGTC_486 niguldipine 82 µM 0.138298161840025 0.44164240058724 no 1469 0.44500238909547 470 1236 A calcium channel blocker.
SGTC_125 0133-0007 11.75 µM 0.1376516214432 0.441905165958214 no 1470 0.445257877901337 493 26541
SGTC_2123 5259487 200 µM 0.137519782747769 0.441958750661198 no 1471 0.445309978462751 491 2173474
SGTC_1058 3448-5425 97.3 µM 0.137391123138441 0.442011044276025 no 1472 0.445360823610487 499 7279705
SGTC_423 5-fluorouracil 457 µM 0.136706174468171 0.442289458209075 no 1473 0.445631524418925 483 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_528 3492-0019 172 µM 0.136533415104177 0.442359684933082 no 1474 0.445699805221228 469 2869262
SGTC_1814 st052110 31.539 µM 0.135937023622704 0.442602132123406 no 1475 0.445935533253365 483 674163
SGTC_3252 9135871 49.47 µM 0.134162063383137 0.443323822132032 no 1476 0.446637211843054 486 17682838
SGTC_2776 terbinafine 19.92 µM 0.133910142694863 0.443426267125295 no 1477 0.446736814907798 481 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_441 propafenone 146 µM 0.133534601123843 0.443578990277787 no 1478 0.446885300777199 496 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1063 disulfiram 1.84 µM 0.132909521375532 0.443833212798173 no 1479 0.447132468372717 478 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2789 5281112 71.43 µM 0.132254458561076 0.444099654359065 no 1480 0.447391513838062 472 765948
SGTC_1000 4048-0884 8.67 µM 0.13106634447578 0.444582974653666 no 1481 0.447861412333882 481 13040088
SGTC_2612 dictamnine 15.46 µM 0.129861800358131 0.445073062748605 no 1482 0.448337883599853 497 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2785 7756463 72.73 µM 0.129355615371039 0.445279037329127 no 1483 0.448538133169594 510 2201551
SGTC_921 1561-0023 372 µM 0.128418975667356 0.445660209577915 no 1484 0.448908707538549 499 24050882
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.128219931135669 0.445741218662138 no 1485 0.448987463746138 479 521171
SGTC_332 4112-0506 40.9 µM 0.126220244554278 0.446555195741025 no 1486 0.449778793343562 508 2790355
SGTC_2560 caryophyllene 100 µM 0.12536028273171 0.446905314663023 no 1487 0.450119164901081 496 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1875 nocodazole 6 µM 0.123903565084837 0.447498486923867 no 1488 0.450695815086482 493 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_351 caspofungin 25 nM 0.123552799273937 0.447641335594511 no 1489 0.450834683375874 471 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1732 st034308 51.822 µM 0.123550682763702 0.447642197559677 no 1490 0.450835521321193 438 830119
SGTC_2576 guaiol 23.12 µM 0.123002023413874 0.447865651652326 no 1491 0.451052747841537 462 227829
SGTC_374 0880-0231 82.3 µM 0.122110336442039 0.448228846869474 no 1492 0.451405817922934 494 6833587
SGTC_26 0302-0163 425.158 µM 0.121503987729467 0.448475845066525 no 1493 0.451645928177816 495 3100915
SGTC_2075 5212009 200 µM 0.118770415776265 0.449589621468824 no 1494 0.45272862376769 511 780898
SGTC_850 0388-0143 75.9 µM 0.117903860295134 0.449942777299674 no 1495 0.453071917256199 489 67273
SGTC_2309 7664088 163.95 µM 0.117815248512794 0.449978892365077 no 1496 0.453107023565324 494 704922
SGTC_1804 st050076 49.1 µM 0.115455690221498 0.450940717312665 no 1497 0.454041969811964 494 3895976
SGTC_3042 9091578 49.47 µM 0.115395890307537 0.450965097273585 no 1498 0.454065668131318 481 25236497
SGTC_950 1165-0508 94.1 µM 0.114762846296147 0.451223195731804 no 1499 0.454316549393409 480 6148369
SGTC_1112 tnp00069 1.16933 µM 0.11476138604957 0.451223791113012 no 1500 0.454317128123892 511 145826
SGTC_1234 0326-0494 15.5 µM 0.113827215225908 0.451604699733387 no 1501 0.454687382085737 503 1547813
SGTC_3265 9137266 49.47 µM 0.113138201415172 0.451885674032807 no 1502 0.454960494531643 487 17224265
SGTC_2903 5923464 63.88 µM 0.112899838393696 0.451982882177365 no 1503 0.455054982227829 497 2876576
SGTC_117 lucigenin 22.078 µM 0.111853328244911 0.452409699267313 no 1504 0.455469851479002 494 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2545 solidagenone 89.61 µM 0.111706578106305 0.452469555428845 no 1505 0.455528031702244 486 6708572 An anti ulcer agent
SGTC_894 0960-0238 55.9 µM 0.110873140339867 0.452809516854617 no 1506 0.455858472579958 512 6741907 YDL195W SEC31
SGTC_1143 3454-2408 5.08 µM 0.110117278511815 0.453117864774918 no 1507 0.456158182609783 495 X1143
SGTC_2026 5148700 152 µM 0.108352744458406 0.453837802350099 no 1508 0.456857942412272 484 79838
SGTC_621 3584-0052 32.1 µM 0.108101500716924 0.45394032328411 no 1509 0.456957588865995 510 2273927
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.107540316506561 0.454169327641555 no 1510 0.457180171404413 486 279621
SGTC_1225 1216-0074 20.6 µM 0.107031276145779 0.454377066661028 no 1511 0.4573820837444 493 4241466
SGTC_2674 ligustilide 100 µM 0.105962304232904 0.454813353915545 no 1512 0.457806130309706 502 5319022 A signalling regulator.
SGTC_501 nsc-95397 161 µM 0.104942802633208 0.455229501289513 no 1513 0.458210597435737 500 262093
SGTC_2377 9073351 62.6 µM 0.102976896488998 0.456032097088719 no 1514 0.458990653693519 497 7337946 YHR072W ERG7
SGTC_2675 theaflavin digallate 100 µM 0.102720170869287 0.456136920548166 no 1515 0.459092532143989 505 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1397 3532-0190 20.1 µM 0.102431542938551 0.456254773663319 no 1516 0.459207073847777 487 5322280
SGTC_391 gliotoxin 8.33 µM 0.1011948583804 0.456759782539996 no 1517 0.459697889092908 489 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_228 caffeine 993.056 µM 0.101073232760018 0.456809453006906 no 1518 0.45974616318687 485 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_3016 9080866 49.47 µM 0.101057551841267 0.45681585695805 no 1519 0.459752387100856 510 17066299
SGTC_2414 st077232 92.9 µM 0.100901758025052 0.456879482409631 no 1520 0.459814223765189 493 729801
SGTC_598 3937-0236 20.2 µM 0.100481368611467 0.457051172952607 no 1521 0.459981086832687 511 1379313
SGTC_164 4100-3994 89.624 µM 0.0991539110921479 0.457593370151954 no 1522 0.460508034038912 524 4615967
SGTC_2101 5377231 179.231 µM 0.0976275574806579 0.458216903537816 no 1523 0.461114020662054 499 2844213
SGTC_361 000s-0510 1.45 µM 0.0973767130952951 0.458319386296584 no 1524 0.461213618544047 485 660
SGTC_952 1185-0122 232 µM 0.0970942344857957 0.458434796570165 no 1525 0.461325779721808 508 678600
SGTC_521 r062-0005 13.8 µM 0.0910144144290701 0.460919618641363 no 1526 0.463740568768149 506 2832033
SGTC_1380 2291-0730 164 µM 0.0903982214075854 0.461171543516241 no 1527 0.463985385009559 482 2999191
SGTC_2019 4016004 108 µM 0.0900411668793873 0.461317529128192 no 1528 0.46412725061588 490 45595336
SGTC_2945 9067681 61.76 µM 0.0896564926349475 0.461474813192874 no 1529 0.464280095245441 510 16456930
SGTC_1158 4092-0494 91.8 µM 0.0893912072039324 0.461583285549845 no 1530 0.464385505565916 508 1148199
SGTC_1221 2958-7315 257 µM 0.0888204888068586 0.46181665583584 no 1531 0.464612287166017 491 4562705
SGTC_502 l-744,832 89.3 µM 0.0883572073010659 0.462006104183167 no 1532 0.464796385923509 520 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_3153 9100258 49.47 µM 0.0882842623970361 0.462035934115423 no 1533 0.464825373449736 510 25236848
SGTC_961 1252-1571 372 µM 0.0875259329693438 0.462346056340047 no 1534 0.465126736499196 511 6813498
SGTC_2580 diallyl disulphide 81.36 µM 0.0851467130711246 0.463319196711983 no 1535 0.466072376730398 515 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1424 4048-1941 275 µM 0.0848573555206728 0.463437563835638 no 1536 0.466187397407446 519 X1424
SGTC_197 4544-0043 41.561 µM 0.082687127382632 0.464325438748802 no 1537 0.467050160339714 495 896523
SGTC_1128 3448-9350 235 µM 0.0821572576583331 0.464542244051873 no 1538 0.467260830969881 492 619386
SGTC_3140 9094243 49.47 µM 0.0820487692803396 0.464586635236554 no 1539 0.467303965941125 515 19291112
SGTC_1615 st002656 86.5 µM 0.0810723304068142 0.464986193457614 no 1540 0.467692215185786 505 1584458
SGTC_2908 7930301 100 µM 0.0797082688795647 0.465544425667132 no 1541 0.46823464138344 490 2223178
SGTC_1137 ixabepilone 100 µM 0.0797028049008222 0.465546661897578 no 1542 0.468236814282422 513 154225 A novel microtubule stabilizer.
SGTC_1909 st060837 51.5 µM 0.0790054883295672 0.465832060006932 no 1543 0.468514128827904 508 678937
SGTC_190 3970-0790 3.722 µM 0.0783818480745144 0.466087318723856 no 1544 0.468762156120714 511 2832352
SGTC_2370 9071495 200 µM 0.077567450001963 0.466420676449314 no 1545 0.469086067738985 515 21791103
SGTC_1252 0493-0875 34.8 µM 0.077292062680644 0.466533406138259 no 1546 0.469195602541284 506 3960963
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.0769995353206934 0.466653155035611 no 1547 0.46931195731603 490 688788
SGTC_2088 5278280 127.392 µM 0.0768530151135864 0.466713135631469 no 1548 0.469370237724579 489 791502
SGTC_377 3970-0964 33.1 µM 0.0758169558325146 0.46713728601664 no 1549 0.469782363074156 512 16481235
SGTC_1028 k015-0029 4.8 µM 0.0753849200226911 0.467314167407753 no 1550 0.469954228572765 524 4588309
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.0746967152008754 0.467595941224521 no 1551 0.470228010631764 522 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3241 9133421 49.47 µM 0.0746143248060245 0.467629675668362 no 1552 0.470260788174426 518 17018221
SGTC_213 1246-0773 967 nM 0.0742919721686067 0.467761664000884 no 1553 0.470389032331021 510 6251622
SGTC_3054 9094397 49.47 µM 0.0734500845229253 0.468106394306435 no 1554 0.470723981752885 500 2598354
SGTC_2215 7188065 200 µM 0.0718196630156692 0.468774075764928 no 1555 0.471372712202108 514 940217
SGTC_541 4513-1321 94 µM 0.0717924511028318 0.46878522019174 no 1556 0.471383540233396 508 747515
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.0714121945285488 0.468940953862977 no 1557 0.471534852279481 508 17037758
SGTC_2126 5251174 33.877 µM 0.0713134707684725 0.46898138685082 no 1558 0.471574137201719 496 790722
SGTC_472 calcifediol 10 µM 0.0709168199666474 0.469143841106839 no 1559 0.471731978340988 513 5283731 A vitamin D metabolite.
SGTC_2301 7769476 200 µM 0.0703428994752736 0.469378907897133 no 1560 0.471960369103941 496 977820
SGTC_1606 st000094 49.2 µM 0.067062620229447 0.470722649540905 no 1561 0.473265925804996 513 1242210
SGTC_2328 6201408 200 µM 0.0667890239697957 0.470834741460121 no 1562 0.473374830750879 514 2890418
SGTC_565 1418-0001 44.5 µM 0.0662944002137079 0.471037393825147 no 1563 0.473571720700596 500 2862145
SGTC_1465 k213-0056 144 µM 0.0659820033763634 0.471165389842671 no 1564 0.473696076726222 511 24048857 YMR208W ERG12
SGTC_2146 5545642 200 µM 0.0659480249420654 0.471179311752031 no 1565 0.473709602699901 507 825326
SGTC_3135 9127742 49.47 µM 0.0659226214527681 0.471189720290993 no 1566 0.473719715220019 530 3643468
SGTC_2975 9084847 53.72 µM 0.0655949465113198 0.471323979884425 no 1567 0.473850156274944 512 27211724
SGTC_3194 9111903 49.47 µM 0.0638164284319473 0.472052755827908 no 1568 0.474558198462887 523 17087251
SGTC_2339 9000433 200 µM 0.0629708568490632 0.472399275143926 no 1569 0.474894855557288 519 2988954
SGTC_1384 3089-0840 101 µM 0.0626810539116073 0.472518042606751 no 1570 0.475010242255307 511 1069836
SGTC_1700 st030840 7.9285 µM 0.0624030396539931 0.47263198111213 no 1571 0.475120937192981 499 5499307
SGTC_3028 9087778 49.47 µM 0.0619469838290886 0.472818891188754 no 1572 0.475302525816281 524 17217395
SGTC_2932 9016711 44.54 µM 0.0611942422051782 0.473127408148137 no 1573 0.475602257597777 508 7117328
SGTC_902 1120-0002 2.07 µM 0.061144917546816 0.473147624804523 no 1574 0.475621898509695 512 3280475
SGTC_406 estrone 100 µM 0.0606498284313797 0.473350550388036 no 1575 0.475819044592133 526 5870 A steroid.
SGTC_2428 5615643 7.78 µM 0.0597786690024164 0.473707635258388 no 1576 0.476165957429346 528 2253075
SGTC_3145 9085516 49.47 µM 0.0591688877186078 0.473957594827729 no 1577 0.476408795107243 525 25236195
SGTC_2696 st077691 74.316 µM 0.0591194552499521 0.473977858475808 no 1578 0.476428481347325 524 757133
SGTC_3110 9122132 49.47 µM 0.0582993149686236 0.474314064985468 no 1579 0.476755106582329 519 918317
SGTC_2813 7971799 71.43 µM 0.0576062629493111 0.474598187482663 no 1580 0.477031130423845 515 2234054
SGTC_2969 9091408 28.7 µM 0.0568262912055413 0.474917958895607 no 1581 0.477341785210045 483 4286311
SGTC_968 1309-0633 340 µM 0.0566627639662049 0.474985003554955 no 1582 0.477406918193089 523 3761976
SGTC_1690 st023502 41.2 µM 0.0566227335171769 0.475001415777714 no 1583 0.477422862433423 527 24207482
SGTC_1146 3579-1023 7 µM 0.0565853457760667 0.475016744545792 no 1584 0.477437754108408 518 X1146
SGTC_2634 4'-methoxyflavone 100 µM 0.0564567694011415 0.475069460433976 no 1585 0.477488966792437 512 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2041 5107442 45.335 µM 0.0553256592132727 0.475533230572507 no 1586 0.477939510186339 518 793005
SGTC_1866 st057638 64 µM 0.0549673619743997 0.475680144123055 no 1587 0.478082232918299 512 688802
SGTC_2555 cholic acid 100 µM 0.0545748557572207 0.475841088264357 no 1588 0.478238585547557 505 6708657 Influences liver metabolism.
SGTC_1295 1013-0063 9.78 µM 0.0544764580000372 0.475881436123288 no 1589 0.478277782263006 516 6826038
SGTC_2987 9018338 71.43 µM 0.0522939226528803 0.476776444434962 no 1590 0.479147247856805 522 5055682
SGTC_679 0422-0091 41.4 µM 0.0517082627908603 0.477016630404697 no 1591 0.47938057664722 528 627384 YHR062C RPP1
SGTC_3162 9099653 49.47 µM 0.0513751809594691 0.477153234895681 no 1592 0.479513280687467 533 25237511
SGTC_601 0986-0029 62.9 µM 0.0491720401199504 0.478056860286734 no 1593 0.480391096527857 538 24747981
SGTC_2983 9022671 12.99 µM 0.0490257616013966 0.478116860942687 no 1594 0.480449382915655 529 6405161
SGTC_2722 naftopidil 47.16 µM 0.0489605157205191 0.47814362371756 no 1595 0.48047538103542 524 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2882 9058044 58.44 µM 0.0488228637697885 0.478200086580864 no 1596 0.480530230623157 511 18076804
SGTC_2835 9006588 71.43 µM 0.048629908487095 0.478279234817016 no 1597 0.480607117314807 512 2345538
SGTC_1504 k297-0033 30 µM 0.0436002067068652 0.480342658824863 no 1598 0.48261154346381 528 4388117
SGTC_577 r071-0003 38.6 µM 0.0417495510423155 0.481102021730314 no 1599 0.483349176175633 527 4568517 YMR134W ERG29
SGTC_674 0498-0004 451 µM 0.0412791687411838 0.481295040511639 no 1600 0.483536669924838 519 4231473
SGTC_2647 atorvastatin 60.16 µM 0.0404099420293649 0.481651734400972 no 1601 0.483883152065751 527 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1940 st075990 51.1 µM 0.0388989160730719 0.482271830358184 no 1602 0.484485490382427 529 1084979
SGTC_568 1193-0097 7.48 µM 0.0383879474965248 0.482481531802235 no 1603 0.484689185202313 519 3646150
SGTC_2420 aureobasidin a 50 nM 0.0383468614193767 0.482498393734789 no 1604 0.484705564115831 486 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2982 9019404 25.97 µM 0.0370489800153026 0.483031066742347 no 1605 0.485222976060268 503 22333232
SGTC_1206 3978-0017 132 µM 0.0365996540383361 0.48321548501233 no 1606 0.485402109692154 522 3873677
SGTC_929 2805-0021 398 µM 0.0351161407255398 0.48382439332013 no 1607 0.485993565456111 522 3098024
SGTC_1178 0988-0033 191 µM 0.0347937559709543 0.483956721239988 no 1608 0.486122099815973 528 5392207
SGTC_592 k241-0073 46.5 µM 0.0333411055974938 0.484553006262999 no 1609 0.486701287220646 535 4230158
SGTC_772 k072-0172 35.3 µM 0.0332472761224889 0.484591522658828 no 1610 0.486738699024061 529 5861980
SGTC_176 1486-1328 72.834 µM 0.0329972913461856 0.484694140501995 no 1611 0.486838373829626 525 22310231
SGTC_1400 3771-8998 51.5 µM 0.0318246232833202 0.485175529904257 no 1612 0.487305955019452 524 670767
SGTC_931 2812-0076 566 µM 0.0317320059504189 0.485213550972836 no 1613 0.487342885337474 529 3450959
SGTC_1564 D-Arginine 115 µM 0.0297149454639098 0.486041623061778 no 1614 0.488147196214419 530 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1373 2887-0003 58.5 µM 0.0296509409436803 0.486067900103316 no 1615 0.488172719077389 537 776948
SGTC_1484 3473-2379 286 µM 0.0288763314460452 0.486385920622958 no 1616 0.48848161125924 538 671917
SGTC_1428 4049-0204 61.7 µM 0.0288438040875078 0.486399275113598 no 1617 0.488494582394853 534 X1428
SGTC_3231 9132313 49.47 µM 0.0280823455455772 0.486711905223639 no 1618 0.488798237367227 531 4905967
SGTC_3007 9078383 71.4286 µM 0.0278722120930861 0.486798180630352 no 1619 0.48888203568373 522 6496995
SGTC_732 3970-1727 52.7 µM 0.0275659425592242 0.486923928152133 no 1620 0.489004172618706 539 1275699
SGTC_2138 5575593 77.673 µM 0.027402979712052 0.486990837636918 no 1621 0.489069160837962 539 762213
SGTC_1070 indatraline 8.81 µM 0.0266520831975129 0.487299146346686 no 1622 0.48936861580476 536 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2073 5212005 126 µM 0.0264328156360665 0.487389176302921 no 1623 0.489456060097817 542 691789
SGTC_265 mycophenolic acid 32.932 µM 0.0261143042010567 0.487519956346802 no 1624 0.489583083925659 534 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2519 cryptotanshinone 88.04 µM 0.0260550720235903 0.487544277087561 no 1625 0.489606706107845 538 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_247 mechlorethamine 29.705 µM 0.0259645888389435 0.487581429585852 no 1626 0.489642791467712 539 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_435 c-PAF 6.7 µM 0.0251074253414618 0.487933387191731 no 1627 0.489984638742246 537 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1328 1441-0025 69.2 µM 0.0250597576433591 0.487952960175836 no 1628 0.490003649420855 523 4562601
SGTC_2729 fluphenazine 10.66 µM 0.0250259817008644 0.487966829039852 no 1629 0.490017119847755 537 3372 An atypical antipsychotic.
SGTC_2368 9071271 200 µM 0.0241884010186317 0.488310755737486 no 1630 0.490351165035576 540 27209959
SGTC_1417 3966-0327 90.4 µM 0.0241732884031326 0.488316961347961 no 1631 0.490357192334488 533 651118
SGTC_3336 9143619 71.43 µM 0.0224874110456791 0.489009241337178 no 1632 0.4910295769962 542 45595730
SGTC_149 3970-0822 46.1 µM 0.0216394914488433 0.489357439316613 no 1633 0.491367765639192 531 3114250 YBL034C STU1
SGTC_331 k048-0133 24.5 µM 0.0203530953750369 0.489885712956797 no 1634 0.491880850279312 542 6813582
SGTC_1204 4049-0315 18.3 µM 0.0202647514146707 0.489921993102264 no 1635 0.491916087152793 527 588402
SGTC_2854 9024559 71.43 µM 0.0201712961312594 0.489960372401543 no 1636 0.491953362797326 533 3163529
SGTC_2000 st075254 36.4 µM 0.0200944554068778 0.489991928666309 no 1637 0.491984011599021 536 17234175
SGTC_2918 7977171 22.06 µM 0.0200795430905212 0.489998052730928 no 1638 0.491989959552431 540 2236483
SGTC_216 k038-0035 28.382 µM 0.0183097702470522 0.490724864495497 no 1639 0.492695866621931 536 4444231 YPR107C YTH1
SGTC_2512 diallyl trisulfide 49.23 µM 0.0181542331192721 0.49078874211819 no 1640 0.492757906646221 540 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_614 0462-0418 107 µM 0.0175221074383329 0.491048352551802 no 1641 0.493010048183727 528 5188303
SGTC_2669 eugenol 100 µM 0.0174287974775133 0.491086674747573 no 1642 0.493047267788559 540 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1968 st069590 43.6 µM 0.0168198036134535 0.491336789193475 no 1643 0.493290185566266 541 6384066
SGTC_1651 st011928 86.1 µM 0.0152218119659687 0.491993102053047 no 1644 0.493927610122418 539 720198
SGTC_1241 0364-0022 50.8 µM 0.0146228615423178 0.492239103302926 no 1645 0.49416653016433 536 4563895
SGTC_812 4251-0442 148 µM 0.0135482285369199 0.492680484503349 no 1646 0.49459520415835 545 5723007
SGTC_55 0767-0285 6.563 µM 0.0129623113542647 0.492921140543231 no 1647 0.494828930757944 540 3116166
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.0126341910653674 0.493055911794831 no 1648 0.49495982109361 543 688801
SGTC_2466 5983409 37.09 µM 0.0125551293887313 0.493088385495938 no 1649 0.494991359637664 531 2879657
SGTC_39 0986-0283 58.349 µM 0.0118064663700044 0.493395892713884 no 1650 0.4952900108061 540 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2261 9010538 184.68 µM 0.0114812794670273 0.493529461810595 no 1651 0.49541973281602 539 6457250
SGTC_2180 6301957 200 µM 0.0110822657185848 0.493693355950516 no 1652 0.495578906139694 542 845462
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.0107623392510986 0.49382476591018 no 1653 0.495706530720828 542 6728940
SGTC_3322 9139058 2.11 µM 0.0103208813147436 0.494006096080026 no 1654 0.495882637169994 534 4908926 YPR165W RHO1
SGTC_1461 k072-0203 53.8 µM 0.00906034921132123 0.494523870107299 no 1655 0.496385493076905 536 5418714
SGTC_1521 st012942 49.4 µM 0.00868802453712123 0.494676807362644 no 1656 0.496534023282042 543 24207259
SGTC_2189 6047310 154.431 µM 0.0066892353049611 0.495497849135377 no 1657 0.497331401114775 544 711535
SGTC_2648 atorvastatin 78.68 µM 0.00609735988788459 0.495740977356185 no 1658 0.497567520414281 542 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1175 0741-0056 27.6 µM 0.00499472052684695 0.496193919300193 no 1659 0.498007403088019 544 765927
SGTC_890 0929-0006 47.2 µM 0.00386282927855758 0.496658882425871 no 1660 0.498458957911242 544 1378169
SGTC_3074 9116018 49.47 µM 0.0031525543169089 0.496950654568663 no 1661 0.498742314874995 547 17027303
SGTC_3243 9134147 49.47 µM 0.00271703253458234 0.497129562330576 no 1662 0.498916062178382 546 24282180
SGTC_481 bay k-8644 50 µM 0.00253784184291303 0.497203172149419 no 1663 0.498987548674696 542 2303 A calcium channel antagonist.
SGTC_2889 9059656 51.95 µM 0.00142532334386809 0.497660186120317 no 1664 0.499431378447418 547 3949838
SGTC_1088 bifonazole 369 nM 0.00139094419962129 0.497674308858132 no 1665 0.499445093728024 547 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2598 perillyl alcohol 100 µM 0.000822131686821237 0.497907973896813 no 1666 0.499672016947017 547 10819 An apoptosis inducer.
SGTC_3034 9090421 49.47 µM 0.000323636504561493 0.498112753557291 no 1667 0.499870887717103 544 17173761
SGTC_279 1273-0055 2.93 µM -0.000121075284179085 0.498295439654122 no 1668 0.499951697950147 549 2847562
SGTC_464 bw-b 70c 158 µM -0.000217781736074309 0.498335166385711 no 1669 0.499913117658268 548 5353454
SGTC_1330 1469-0054 61.8 µM -0.00026637443960728 0.498355128134463 no 1670 0.499893731974879 549 7102664
SGTC_3080 9117754 49.47 µM -0.000686299338686657 0.498527632292496 no 1671 0.499726206198279 549 9550191
SGTC_316 k060-0003 58.6 µM -0.000828410315533517 0.498586011210535 no 1672 0.499669512137413 551 6152314
SGTC_609 0986-0026 86.3 µM -0.00155646672545652 0.498885095842053 no 1673 0.499379059865891 551 2848610
SGTC_1734 st037168 69.4 µM -0.00253233856491464 0.499285983684444 no 1674 0.498989744157916 552 708907
SGTC_3053 9095903 49.47 µM -0.00264299631917654 0.499331441907893 no 1675 0.49894559824891 550 17174018
SGTC_1450 4112-4260 37.6 µM -0.00287609302232784 0.499427198099148 no 1676 0.498852606472882 551 1633175
SGTC_166 k072-0058 166.424 µM -0.00427044796540931 0.5 no 1677 0.498296342928533 549 5846229
SGTC_2308 7584454 197.62 µM -0.00636438879908644 0.499139808139609 no 1678 0.497460993359742 551 893577
SGTC_1014 4130-3005 69.3 µM -0.00697779321033588 0.498887821903364 no 1679 0.497216285854171 559 743608
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.00752651681257118 0.498662406885272 no 1680 0.49699738256828 554 803109
SGTC_3095 9117207 49.47 µM -0.00810608270211265 0.498424322356585 no 1681 0.496766176296728 551 17015229
SGTC_1408 3909-7976 48.8 µM -0.0083307734249144 0.498332019995435 no 1682 0.496676540694737 551 24152374
SGTC_2211 7117706 200 µM -0.00881046852794449 0.498134962807016 no 1683 0.49648517706676 550 822771
SGTC_474 dl-dihydrosphingosine 5 µM -0.00951666405206248 0.497844860824002 no 1684 0.496203457648184 554 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2445 5742597 35.57 µM -0.0102329283940701 0.497550623780207 no 1685 0.49591772345586 554 1774255
SGTC_1181 1222-0449 220 µM -0.0106383319930704 0.497384087022868 no 1686 0.495755999626994 556 658318
SGTC_2118 5526350 200 µM -0.011482950743411 0.497037125474015 no 1687 0.495419066117158 559 743594
SGTC_2819 7996655 46.38 µM -0.0121649491329932 0.496756968484204 no 1688 0.495147007148035 556 6456960
SGTC_1040 k898-0338 155 µM -0.0130057543991119 0.496411577696522 no 1689 0.494811600951401 552 20969351
SGTC_3227 9130768 49.47 µM -0.0134045391769254 0.49624776353324 no 1690 0.494652522714115 554 17720899
SGTC_1647 st011722 22.4 µM -0.0134953402350307 0.496210464054129 no 1691 0.494616301609307 560 2854783
SGTC_2886 9058944 51.95 µM -0.0150493792105788 0.495572097557452 no 1692 0.493996392959932 552 4949929
SGTC_2533 agelasine 13.65 µM -0.0154115994206836 0.495423306689656 no 1693 0.493851904763372 554 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1135 dihydrocapsaicin 536.708 nM -0.0154927558212565 0.495389969786927 no 1694 0.493819531908927 562 107982 A Capsaicinoid.
SGTC_1338 1486-1223 76 µM -0.0155022335964397 0.495386076569669 no 1695 0.493815751277711 558 3444526
SGTC_891 0929-0073 133 µM -0.016058814023443 0.495157448958259 no 1696 0.493593735461259 553 5603632
SGTC_1996 st072960 66.8 µM -0.0166753179093128 0.49490420833231 no 1697 0.493347818939417 558 1719405
SGTC_1299 1079-1439 3.74 µM -0.0168976570272679 0.494812878834863 no 1698 0.493259130961263 558 323161
SGTC_1896 st058441 89 µM -0.0196610805750322 0.493677780777565 no 1699 0.492156868987785 558 688759
SGTC_1742 st038235 28.8875 µM -0.0202609511050887 0.4934313856626 no 1700 0.491917602945753 553 564103 YBR002C RER2
SGTC_2315 7733312 200 µM -0.0205139989873349 0.493327447710425 no 1701 0.49181667242485 558 726316
SGTC_2967 9089538 49.85 µM -0.0214455229159893 0.492944833608911 no 1702 0.491445129934215 555 728216
SGTC_2025 5147754 141 µM -0.0214592459688016 0.492939197050393 no 1703 0.49143965648783 554 315777 YLR208W SEC13
SGTC_211 3455-0679 143.504 µM -0.0223297671007245 0.492581645186945 no 1704 0.491092452042853 559 748649
SGTC_975 1335-0046 28.5 µM -0.0226038419463721 0.492469074789635 no 1705 0.490983139590883 566 16486740
SGTC_3315 9136395 68.55 µM -0.0234174085749752 0.492134923216082 no 1706 0.490658659389457 560 16876844
SGTC_1701 st028638 40.4 µM -0.0238755933217294 0.491946738026995 no 1707 0.490475921220146 560 3490878
SGTC_2103 5378138 10 µM -0.0239831941348093 0.491902544585093 no 1708 0.490433006994866 561 244142
SGTC_2043 5101342 149 µM -0.0241748652323152 0.491823822326976 no 1709 0.490356563454439 558 678451
SGTC_3199 9111318 49.47 µM -0.0249963825592151 0.491486416212285 no 1710 0.490028924503989 562 8548020
SGTC_1727 st034309 9.9045 µM -0.0253991428640957 0.491321000378231 no 1711 0.48986829739195 593 870305
SGTC_2741 miltefosine 3.04 µM -0.0257452678517225 0.49117884616652 no 1712 0.489730258642521 560 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2931 9014674 55.67 µM -0.025880734761303 0.491123209944951 no 1713 0.48967623316662 565 2996810
SGTC_1605 st000082 49.1 µM -0.028517420888122 0.490040359415479 no 1714 0.488624736910023 583 1114022
SGTC_430 0958-0115 16.4 µM -0.0289198352323302 0.489875099667427 no 1715 0.488464263004804 571 6833180
SGTC_483 fpl-64176 144 µM -0.0302301707862812 0.489336995545879 no 1716 0.487941743357115 563 3423
SGTC_823 0417-1665 178 µM -0.0309433408754567 0.489044132272977 no 1717 0.487657362718668 567 3429856
SGTC_2009 4012297 12.05 µM -0.0321500397826096 0.488548614943682 no 1718 0.487176199019182 573 45595307
SGTC_2887 9044784 58.44 µM -0.032602624724442 0.488362770546397 no 1719 0.4869957383586 567 6465546
SGTC_210 3551-0445 56.827 µM -0.0332106202858495 0.488113114062305 no 1720 0.486753314515949 560 2865180 YOR207C RET1
SGTC_2683 piperine 63.03 µM -0.0358987089943657 0.487009382279507 no 1721 0.485681562639361 572 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2263 7948595 193.29 µM -0.0360540949138589 0.486945583633852 no 1722 0.485619612730263 590 2971371
SGTC_545 4218-0007 221 µM -0.036477298615433 0.486771825553908 no 1723 0.485450889870447 567 2840508
SGTC_2718 lomofungin 53.02 µM -0.0383123031474143 0.486018442752086 no 1724 0.484719340747919 568 5351222 A RNA synthesis inhibitor.
SGTC_1613 st002381 52.1 µM -0.0385802260369037 0.48590844795345 no 1725 0.484612533945293 562 551167
SGTC_2210 7115885 190.385 µM -0.0390768242179703 0.485704574160766 no 1726 0.484414569223977 566 2927039
SGTC_246 cycloheximide 667 µM -0.0394399331777074 0.485555505495797 no 1727 0.484269821295552 561 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2649 anisomycin 9.56 µM -0.0396616660713263 0.485464477539615 no 1728 0.484181431828863 581 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1980 st071811 45.7 µM -0.0398229427036173 0.485398269154673 no 1729 0.484117142552397 563 4974850
SGTC_1780 st038448 24.544 µM -0.0399166196831277 0.485359812425726 no 1730 0.484079800535806 591 728868 YDL195W SEC31
SGTC_1819 st053448 58.6 µM -0.0400971223088912 0.485285711994729 no 1731 0.484007848011606 563 2857616
SGTC_1194 1488-0194 225 µM -0.0404485042215729 0.485141463191708 no 1732 0.483867780544535 568 1391452
SGTC_2158 5657123 3.6195 µM -0.0408012673987739 0.484996649309804 no 1733 0.483727164481862 588 2858827
SGTC_259 usnic acid 108.925 µM -0.0417252541552373 0.484617350131744 no 1734 0.483358860792142 593 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3307 9126885 69.2785 µM -0.0422245426504515 0.484412396562335 no 1735 0.483159848899335 578 24824909
SGTC_291 SEC14.278 35.5 µM -0.0439368743696745 0.483709530950004 no 1736 0.482477361086471 570 1068044
SGTC_2165 5727197 32.143 µM -0.0448162691488034 0.4833485828398 no 1737 0.482126878608238 580 1361712
SGTC_716 1683-5115 658 µM -0.0451070633705625 0.483229229166289 no 1738 0.482010985699649 577 723597
SGTC_866 0495-0101 262 µM -0.0458000584429233 0.48294480212487 no 1739 0.481734806115233 588 635694
SGTC_1436 4092-1007 8.32 µM -0.0465472324729771 0.48263814805799 no 1740 0.481437044394806 565 2881121
SGTC_2981 9013952 38.96 µM -0.0468013933580875 0.482533838053233 no 1741 0.481335759256496 571 2996344
SGTC_3115 9123671 49.47 µM -0.04710640154635 0.482408661418536 no 1742 0.481214212653658 565 3286988
SGTC_2399 5884133 200 µM -0.0481260911987603 0.481990189184775 no 1743 0.480807876261868 572 722445
SGTC_1573 oleylamine 1.06 µM -0.0489678273399587 0.481644762536192 no 1744 0.480472467615829 572 5356789 An amine of the fatty acid oleic acid.
SGTC_1757 st041620 31.8375 µM -0.049146250605067 0.481571544023977 no 1745 0.480401372631503 570 5289815
SGTC_2156 5649887 115 µM -0.0507734252685941 0.480903838862507 no 1746 0.479753033559591 576 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_3202 9113761 49.47 µM -0.0509165305540131 0.480845118668604 no 1747 0.479696016558901 567 4798415
SGTC_2518 prenyletin 46.28 µM -0.0512215219252078 0.480719973369364 no 1748 0.479574501168436 561 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2196 6573537 42.6665 µM -0.0512583509526607 0.480704861661442 no 1749 0.479559827787598 578 2903087
SGTC_2812 7970281 58.44 µM -0.0512728807038261 0.480698899813136 no 1750 0.479554038867648 589 2233435
SGTC_2737 bleomycin 30.5 nM -0.0526624991629788 0.480128731634809 no 1751 0.479000409437225 568 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2625 euphol 100 µM -0.0536949980200897 0.479705117874418 no 1752 0.478589084028163 571 6708538 A triterpene alcohol.
SGTC_662 k832-1615 104 µM -0.054400273353069 0.479415770569249 no 1753 0.478308130537362 569 5878478
SGTC_2667 digitoxin 100 µM -0.0557112047714022 0.478877974833904 no 1754 0.477785936625212 564 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1853 st056710 91.2 µM -0.0563812793380779 0.478603098626428 no 1755 0.477519035076961 588 269167
SGTC_3200 9114385 49.47 µM -0.0574840207731924 0.478150757183093 no 1756 0.477079817317599 581 17018030 YLR208W SEC13
SGTC_2348 9022543 33.42 µM -0.0590432726497645 0.477511204606901 no 1757 0.47645882080975 585 3162678 YDL140C RPO21
SGTC_766 1391-0721 126 µM -0.06170583750496 0.476419245002727 no 1758 0.475398545586991 608 1020919 YIL115C NUP159
SGTC_2984 9022109 38.96 µM -0.0621799493642681 0.476224822628757 no 1759 0.475209764838571 590 6459207
SGTC_1190 1486-1332 13 µM -0.0634987045424193 0.475684061358642 no 1760 0.474684695394698 574 4150046
SGTC_1254 0550-0035 264 µM -0.0636472294683038 0.475623160857291 no 1761 0.474625562137124 579 15121435
SGTC_2484 5809818 12.04 µM -0.064313009190165 0.475350174513459 no 1762 0.474360497532199 578 2870548
SGTC_3204 9114183 49.47 µM -0.0643392402670594 0.47533941935171 no 1763 0.474350054474836 586 17027248
SGTC_182 3448-4371 550.524 µM -0.0652623615069588 0.474960936354891 no 1764 0.473982554797892 572 3491403
SGTC_1902 st060212 70.5 µM -0.0657768066692563 0.474750021788434 no 1765 0.473777760917258 576 688944
SGTC_487 nimodipine 119 µM -0.0662086828133484 0.474572964704754 no 1766 0.473605842029716 578 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1958 st076513 41.9 µM -0.0680031665149409 0.473837330987638 no 1767 0.472891556803697 593 732122 YGL099W LSG1
SGTC_257 daunorubicin 18.5 µM -0.0680115293904546 0.473833902903034 no 1768 0.472888228205359 580 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2342 7990637 118.86 µM -0.0682972248514638 0.473716792650299 no 1769 0.472774516610217 601 2033102 YER133W GLC7
SGTC_2807 7945238 51.95 µM -0.0683091100167779 0.473711920816952 no 1770 0.472769786162675 592 17148797
SGTC_2815 7968870 71.43 µM -0.0690033907943037 0.473427335893316 no 1771 0.472493460235741 593 2977326 YHR190W ERG9
SGTC_948 3448-0295 75.3 µM -0.0695891223012235 0.473187255736609 no 1772 0.472260347548647 584 678569
SGTC_258 haloperidol 50.781 µM -0.0706187686585381 0.472765247023207 no 1773 0.471850586237964 569 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2070 5230947 200 µM -0.0709407057394741 0.472633304811918 no 1774 0.47172247323597 603 2835538
SGTC_1524 corynanthine 62.1 µM -0.0721731897305994 0.472128213296356 no 1775 0.471232040506706 627 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_237 nikkomycin 200 µM -0.0730073073707342 0.471786404019747 no 1776 0.470900151294984 594 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_10 0279-0212 42.575 µM -0.0730808541858149 0.471756266597874 no 1777 0.470870888529916 594 39851 YBR002C RER2
SGTC_300 r073-0011 5.04 µM -0.0737544366678031 0.471480258935185 no 1778 0.470602891250587 578 2735780
SGTC_2788 5282734 71.43 µM -0.0739168816347974 0.471413697408702 no 1779 0.470538261496574 586 743706
SGTC_3324 9138759 60.749 µM -0.0740353845092473 0.471365141577433 no 1780 0.470491114870496 590 45595710
SGTC_3285 9112818 20.8695 µM -0.0741686327710724 0.471310544421888 no 1781 0.470438102254085 574 17017947 YPR165W RHO1
SGTC_1774 st048371 48.465 µM -0.0746642218857566 0.471107486430772 no 1782 0.470240937491026 579 4242727
SGTC_2717 st081029 62.2815 µM -0.0748603498487123 0.4710271288879 no 1783 0.470162912116835 594 5292846
SGTC_1937 st074714 47.2 µM -0.074961898740164 0.470985522742562 no 1784 0.470122513481733 605 17250970
SGTC_2730 imipramine 71.33 µM -0.0757930905203838 0.470644982610014 no 1785 0.469791856640055 590 3696 A tricyclic antidepressant.
SGTC_3087 9117406 49.47 µM -0.0767513412778291 0.470252412936973 no 1786 0.469410680263726 580 42546093
SGTC_3253 9135987 49.47 µM -0.077711207169681 0.469859210569816 no 1787 0.469028889517988 594 4182430
SGTC_3100 9120536 49.47 µM -0.0777209854966419 0.469855205096958 no 1788 0.469025000292739 607 16421196
SGTC_2208 7283366 200 µM -0.0778719502121113 0.469793366166299 no 1789 0.468964956062712 580 898663
SGTC_49 0717-0965 32.132 µM -0.0779431384540342 0.469764205931108 no 1790 0.46893664212061 642 5889349 YGL099W LSG1
SGTC_2461 5755302 26.15 µM -0.0795360347170301 0.469111764057467 no 1791 0.468303135413089 606 2788904
SGTC_2950 9072895 21.46 µM -0.0805116365419766 0.468712203558446 no 1792 0.467915170829059 596 17332245
SGTC_3237 9133362 49.47 µM -0.0805290963633181 0.468705053124837 no 1793 0.467908227911942 595 43845137
SGTC_542 3381-0244 89.3 µM -0.0805395492352908 0.468700772297374 no 1794 0.467904071320603 582 1112843
SGTC_1097 itavastatin 7.23 µM -0.0805797422801995 0.46868431183191 no 1795 0.467888088562751 584 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_373 0844-0104 25.9 µM -0.0805934165817719 0.4686787117367 no 1796 0.467882650990727 598 5375804
SGTC_1358 1509-0022 2.48 µM -0.0813149004534519 0.46838324817732 no 1797 0.467595762191526 582 3258434
SGTC_289 k017-0060 526 µM -0.0828559620168942 0.467752208003466 no 1798 0.466983035400873 590 5512909
SGTC_3158 9100007 49.47 µM -0.0836299399995734 0.467435306810701 no 1799 0.466675330818488 588 19297233
SGTC_58 0957-0393 9 µM -0.0840894966107771 0.467247153538477 no 1800 0.466492637778412 581 6997992
SGTC_2154 5570129 200 µM -0.0844663633511589 0.467092860901304 no 1801 0.466342822699344 589 673366
SGTC_311 1315-0136 58 µM -0.0852313688455942 0.466779675992794 no 1802 0.466038726288027 596 6759207
SGTC_3212 9128307 49.47 µM -0.0852899074172583 0.466755711784466 no 1803 0.466015457505417 623 27243542
SGTC_2121 5257820 149.641 µM -0.0856250480389043 0.466618516026456 no 1804 0.465882243062604 575 791256
SGTC_2638 epoxomicin 18 µM -0.0858441959431355 0.466528806088465 no 1805 0.465795136422553 597 9915668 A protesome inhibitor.
SGTC_3019 9081971 49.47 µM -0.0866738863583187 0.46618918116059 no 1806 0.465465366975602 592 16451803
SGTC_3236 9132701 49.47 µM -0.0878794034873858 0.465695759513529 no 1807 0.464986263447948 594 24282524
SGTC_1349 flufenamic acid 69 µM -0.0908363860736578 0.46448568283782 no 1808 0.463811298823171 599 3371 A non-steroidal anti-inflammatory.
SGTC_879 0831-1030 162 µM -0.0922990446126251 0.463887244388395 no 1809 0.463230223709978 589 1549252
SGTC_101 0490-5701 117.494 µM -0.0924154913183253 0.463839604372066 no 1810 0.463183965903414 592 4661669
SGTC_626 0214-0009 33 µM -0.0924279608753011 0.463834502928302 no 1811 0.463179012470714 608 3437874
SGTC_3271 9137798 49.47 µM -0.0936812166478294 0.463321811589079 no 1812 0.462681195796166 586 6498326
SGTC_669 0108-0021 26.2 µM -0.0938643046479417 0.463246917645976 no 1813 0.462608474686275 655 17201
SGTC_252 miconazole 1.30953 nM -0.0945963163289978 0.46294749412638 no 1814 0.462317737929891 599 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2448 5185112 27.17 µM -0.0983183004197999 0.461425374587662 no 1815 0.460839773475219 590 5718189
SGTC_1953 st076800 12.1 µM -0.0985020690451891 0.46135023616105 no 1816 0.460766814545313 594 297591
SGTC_806 3966-4455 5.86 µM -0.0988432184700077 0.461210752294378 no 1817 0.460631376555755 631 714982
SGTC_973 1325-0077 65.9 µM -0.0992225395155007 0.461055667012742 no 1818 0.46048078960887 601 2835149
SGTC_1672 st016598 6.51 µM -0.0993777976069591 0.460992191501233 no 1819 0.460419155215885 638 4665860 YNL267W PIK1
SGTC_2676 harmalol 100 µM -0.100698907684009 0.460452110985689 no 1820 0.459894739254721 593 5459187 A monoamine oxidase inhibitor
SGTC_1654 st012436 41.8 µM -0.100721257259549 0.460442974922615 no 1821 0.459885868165955 601 4323132
SGTC_2027 5150920 200 µM -0.100900940334749 0.460369524805541 no 1822 0.459814548320051 593 786715
SGTC_830 4076-0286 57.8 µM -0.101211105961155 0.460242739744741 no 1823 0.459691440354822 590 6866659
SGTC_358 0075-0058 9.45 µM -0.101854683502413 0.459979680247957 no 1824 0.459436010072606 654 1069125
SGTC_284 0988-0104 32.6 µM -0.101950679931076 0.459940443627372 no 1825 0.459397911364351 590 4666532
SGTC_3142 9086498 49.47 µM -0.102299336753071 0.459797940407742 no 1826 0.459259540870812 626 25236367
SGTC_1944 st076371 56.9 µM -0.102349859394234 0.45977729119234 no 1827 0.459239490495333 588 24208455
SGTC_1023 4482-3888 16 µM -0.102873411367791 0.459563315556914 no 1828 0.459031720185907 597 3303168
SGTC_964 1287-0107 19.4 µM -0.104511590897531 0.45889386769955 no 1829 0.45838168522321 613 51516812 YPR165W RHO1
SGTC_821 1114-0266 29.2 µM -0.104540372962865 0.458882106843156 no 1830 0.458370265395836 611 3123235
SGTC_2045 5106652 78.05 µM -0.104776533514417 0.458785608862365 no 1831 0.458276565540486 587 673349
SGTC_1290 0986-0249 10.2 µM -0.105323545618687 0.458562102615651 no 1832 0.458059540090067 600 53329
SGTC_397 arbidol 50 µM -0.105930183227612 0.458314249026248 no 1833 0.457818873019791 574 131410 A RNA synthesis inhibitor.
SGTC_1588 farnesol 29.9 µM -0.10600537084976 0.458283530788313 no 1834 0.457789045438863 584 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3011 9081274 71.4286 µM -0.106214142347871 0.458198237569743 no 1835 0.457706225224354 589 6625322
SGTC_869 0564-0080 44.1 µM -0.107329580505728 0.457742560034838 no 1836 0.457263759114445 591 6843321
SGTC_2258 7960471 200 µM -0.108839113895373 0.457125975713561 no 1837 0.456665049840182 618 2974708
SGTC_3270 9137563 49.47 µM -0.10893709856631 0.457085956425187 no 1838 0.456626190665559 588 17015724
SGTC_876 0720-0963 56.8 µM -0.109629103419904 0.45680333746797 no 1839 0.456351764288248 636 765861
SGTC_1685 st024049 53.0905 µM -0.110440106250246 0.456472146835647 no 1840 0.456030173730499 608 1941139
SGTC_2092 5303694 80.6725 µM -0.111151300891132 0.45618173992235 no 1841 0.455748184254561 618 1963699
SGTC_567 1080-0542 68.4 µM -0.111542495737785 0.456022010655406 no 1842 0.455593084550906 589 5950415
SGTC_2607 solasodine 47.35 µM -0.111722015966927 0.455948712899161 no 1843 0.455521911198532 603 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_966 1300-0360 30.2 µM -0.111854891612683 0.455894460999865 no 1844 0.455469231674941 602 70588
SGTC_2831 7999036 19.48 µM -0.111978286237294 0.455844080850357 no 1845 0.455420311672801 617 2988270
SGTC_1335 1486-0900 202 µM -0.112065900766579 0.45580830960085 no 1846 0.455385577158697 581 X1335
SGTC_1308 1187-1617 41.4 µM -0.113053190583682 0.455405243862637 no 1847 0.454994192745206 595 2882570
SGTC_3222 9128301 49.47 µM -0.115245608986584 0.45451034340738 no 1848 0.454125224369092 590 4911358
SGTC_2742 clothiapine 36.27 µM -0.118343391890478 0.45324628620345 no 1849 0.452897788593428 600 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_81 0411-0046 9.971 µM -0.118372574487393 0.453234380411482 no 1850 0.452886227682083 597 12925265
SGTC_2438 5259590 200 µM -0.118592400980078 0.453144697884156 no 1851 0.452799143001924 604 1201127
SGTC_1422 4031-0024 15.5 µM -0.119145010995843 0.452919260359256 no 1852 0.452580235536822 612 782427
SGTC_418 lividomycin a 100 µM -0.119468853781536 0.452787155584263 no 1853 0.45245195718081 595 72394 An antibiotic.
SGTC_859 0439-0102 54.6 µM -0.120359603126413 0.452423820336241 no 1854 0.452099145373103 601 610143
SGTC_1085 doxorubicin 7.67 µM -0.121309746204769 0.452036302394318 no 1855 0.451722850338394 596 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2207 7258803 200 µM -0.122193022168589 0.451676097324976 no 1856 0.451373076273706 608 3666799
SGTC_417 st075190 100 µM -0.124748779547013 0.450634069737824 no 1857 0.450361219253256 599 222757
SGTC_857 0438-0306 1.35 µM -0.125849324914685 0.450185462243115 no 1858 0.449925598246142 591 4686136
SGTC_235 0330-0087 5 mM -0.127107369303219 0.449672732529329 no 1859 0.449427709456855 604 46494818 YHR062C RPP1
SGTC_3292 9120825 59.784 µM -0.127939976877298 0.449333440375321 no 1860 0.449098237010978 603 24824900
SGTC_274 sirtinol 40.1 µM -0.128746306636631 0.449004891879441 no 1861 0.448779196448866 601 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1136 pergolide 1.05886 µM -0.12905129299321 0.44888063072093 no 1862 0.448658531093524 603 47811 A dopamine receptor agonist.
SGTC_1078 idebenone 36.1 µM -0.129778970100269 0.448584172159957 no 1863 0.448370650806833 597 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2751 anetholtrithion 17.25 µM -0.131041688076906 0.4480698040356 no 1864 0.447871164704007 626 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_3067 9117431 49.47 µM -0.13130334813286 0.447963227711835 no 1865 0.447767671648473 621 17150885
SGTC_1425 4048-4433 7.33 µM -0.132128043790086 0.447627346902001 no 1866 0.44744150731505 617 23734946
SGTC_3177 9107506 49.47 µM -0.132706997305521 0.447391574002907 no 1867 0.447212554383504 594 8897194
SGTC_250 brefeldin a 552.239 µM -0.132728410454142 0.44738285407306 no 1868 0.447204086677559 592 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2698 st077697 67.5 µM -0.134271565726594 0.446754512739889 no 1869 0.446593918436921 600 3154499
SGTC_2431 5490079 200 µM -0.135143116946989 0.446399693825266 no 1870 0.446249360229666 638 5722345
SGTC_2460 5552655 174.22 µM -0.135266806256105 0.446349341900288 no 1871 0.446200464301467 601 5401989
SGTC_2691 st077356 60.2 µM -0.13603823928734 0.446035323495813 no 1872 0.445895525683526 621 2839272
SGTC_1865 st057639 52.2 µM -0.137031277559749 0.445631148636182 no 1873 0.445503036192719 604 688818
SGTC_1 0258-0098 57.368 µM -0.137465286650527 0.445454521033393 no 1874 0.445331514732029 586 6790032 YDR047W HEM12
SGTC_445 e6 berbamine 66 µM -0.138192044750666 0.445158778352785 no 1875 0.445044321072597 615 6610268 A calcium/calmodulin antagonist.
SGTC_3290 9121031 71.43 µM -0.138559596289306 0.445009220694709 no 1876 0.444899086369274 604 17014854
SGTC_2254 7938975 95.19 µM -0.138620383111687 0.444984487135427 no 1877 0.444875067712298 654 2969277
SGTC_3318 9139014 38.6185 µM -0.139062687752282 0.44480452418884 no 1878 0.444700306271305 604 16643984
SGTC_3260 9137109 49.47 µM -0.139630714751707 0.444573424578907 no 1879 0.444475885742214 600 17478346
SGTC_3181 9108277 49.47 µM -0.140133976184319 0.444368690329821 no 1880 0.444277068165775 622 17097298
SGTC_1370 2001-0092 44.6 µM -0.140565157551993 0.444193291129226 no 1881 0.444106737563636 598 790957
SGTC_785 1270-0111 65.3 µM -0.14166671419891 0.443745241336197 no 1882 0.44367163396716 605 6741994
SGTC_2643 anethole 100 µM -0.143875328343124 0.442847121482855 no 1883 0.442799459047984 632 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2506 ethyl hematommate 54.16 µM -0.143884923913736 0.442843220138152 no 1884 0.44279567038827 618 3940691 An allergen.
SGTC_369 0957-0393 4.5 µM -0.143925207009881 0.442826841991414 no 1885 0.442779765300187 657 6997992
SGTC_636 0kpi-0074 126 µM -0.145935598672879 0.442009589334782 no 1886 0.441986114369742 616 616434
SGTC_3064 1327-0027 10 µM -0.147500170642534 0.44137373926304 no 1887 0.441368622524763 608 16000455 YPR107C YTH1
SGTC_1192 1488-0095 21.4 µM -0.14760256266895 0.441332131867679 no 1888 0.441328216269508 631 915875
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.148074787734401 0.441140249774551 no 1889 0.44114187327607 662 61125 An anti-inflammatory.
SGTC_1157 4092-0394 27.6 µM -0.149576744357369 0.44053004264109 no 1890 0.440549278527777 618 3659885
SGTC_2411 st077133 39.94 µM -0.150095212876529 0.440319434654201 no 1891 0.440344748386197 605 1403142 YNL221C POP1
SGTC_1978 st071761 42 µM -0.151109483446229 0.439907474939948 no 1892 0.439944675848925 607 5147680
SGTC_2837 9008476 45.46 µM -0.151198636094492 0.439871267489562 no 1893 0.439909513082838 665 2992805
SGTC_696 1560-0013 611 µM -0.152102883399603 0.439504055163511 no 1894 0.439552895023374 625 1650269
SGTC_1488 4013-0813 75.9 µM -0.152627734545729 0.439290938418333 no 1895 0.439345926120753 615 2910057
SGTC_2838 9002687 71.43 µM -0.15270646945263 0.439258969485013 no 1896 0.439314879361052 639 6457060
SGTC_1416 3966-0321 25.3 µM -0.153042190435797 0.439122660293862 no 1897 0.439182502006655 632 582530 YLR208W SEC13
SGTC_2357 9067248 200 µM -0.15308574807823 0.439104975580041 no 1898 0.439165327392855 643 9150235
SGTC_1817 st052116 64.4 µM -0.153508062883711 0.438933519061231 no 1899 0.438998816203683 620 4361398
SGTC_2082 5219693 150 µM -0.155930891486179 0.437950091923843 no 1900 0.438043747622812 628 2834649
SGTC_48 0382-0018 55 µM -0.156200189268604 0.437840807389063 no 1901 0.437937613776079 617 762596
SGTC_813 k007-0158 173 µM -0.157091418137945 0.437479169001156 no 1902 0.437586400471923 599 6523916
SGTC_1415 3966-0071 78.1 µM -0.157236671043746 0.437420233945727 no 1903 0.437529164212788 635 2893185
SGTC_1997 st073024 93.8 µM -0.157438640323395 0.437338289041342 no 1904 0.43744958129246 606 686268
SGTC_3308 9128332 17.569 µM -0.157552608541582 0.43729204995386 no 1905 0.437404674967519 603 17332805 YDL196W YDL196W
SGTC_1922 5578187 25 µM -0.158983111827386 0.436711740438226 no 1906 0.436841089702475 601 1350412
SGTC_1704 st028805 70.8 µM -0.159604610914874 0.436459660457437 no 1907 0.436596273281709 615 2876101
SGTC_3005 9076496 71.4286 µM -0.159791839011149 0.436383725809195 no 1908 0.436522526500948 622 21368410
SGTC_1600 coumarin 106 71.1 µM -0.161010716526862 0.435889439514643 no 1909 0.436042480100588 657 100336 A hepatotoxic, DNA x-linker.
SGTC_1031 k035-0009 16 µM -0.161136288476376 0.435838522523532 no 1910 0.435993029805436 665 5180959
SGTC_2418 pentamidine 31.67 µM -0.161224831001562 0.43580262088536 no 1911 0.435958162317152 639 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1438 4092-1045 4 µM -0.162124159327056 0.435437997202752 no 1912 0.435604040739992 616 1351342
SGTC_271 rotenone 740 µM -0.162793201012694 0.435166776521219 no 1913 0.435340630831618 618 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1977 st070720 65.3 µM -0.163162568850164 0.435017052727115 no 1914 0.435195218472427 637 682188
SGTC_2846 9008642 19.48 µM -0.163982112972786 0.434684882616984 no 1915 0.434872612486157 680 2992898
SGTC_604 1000-0114 314 µM -0.166069360239298 0.433839107433585 no 1916 0.434051183144173 639 1572745
SGTC_2992 9074591 71.4286 µM -0.166855030091459 0.433520823744442 no 1917 0.433742058900444 606 17741321
SGTC_2018 5133068 143 µM -0.167578624636992 0.433227725587783 no 1918 0.433457394220082 627 785362
SGTC_1628 st004252 77.7 µM -0.168505282195648 0.432852428669898 no 1919 0.433092894248985 605 692968
SGTC_2409 alverine citrate 63.97 µM -0.168565366364973 0.432828096628972 no 1920 0.433069262152936 618 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1372 2752-0194 270 µM -0.16959954991273 0.432409327531903 no 1921 0.43266253826942 623 823334
SGTC_956 1185-0240 191 µM -0.169649478794784 0.432389111884428 no 1922 0.432642904031739 632 1416193
SGTC_3249 9135183 49.47 µM -0.169824361162205 0.432318305360402 no 1923 0.432574133886431 650 4902779
SGTC_593 1203-0218 61.7 µM -0.169984633535486 0.432253416052242 no 1924 0.432511110718888 637 3666956
SGTC_2757 clomiphene 4.22 µM -0.171162322125068 0.43177666266319 no 1925 0.432048066419243 620 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1556 plumbagin 1.48 µM -0.171237481638474 0.431746239858875 no 1926 0.432018518318658 623 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1001 4048-4355 44.4 µM -0.17170747079885 0.431556008481748 no 1927 0.431833756101773 657 21824233
SGTC_2636 apigenin dimethyl ether 100 µM -0.171753888526357 0.431537221444649 no 1928 0.43181550916536 662 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1986 st071812 45 µM -0.172042358271235 0.431420470133002 no 1929 0.43170211417756 626 11838594
SGTC_3348 9149464 3.537 µM -0.173164911860004 0.430966200209126 no 1930 0.431260901611968 623 1951442
SGTC_1578 josamycin 24.2 µM -0.173321710893376 0.430902754738153 no 1931 0.431199279560398 649 5282165 A P450 substrate.
SGTC_2581 avocatin a 64 µM -0.173983490122767 0.430634999187165 no 1932 0.430939218657308 668 6710728 A skin care supplement.
SGTC_2269 7935389 174.42 µM -0.174252581028487 0.430526134250463 no 1933 0.43083348194261 602 97605
SGTC_1988 st071872 53.4 µM -0.174978936957382 0.430232301977151 no 1934 0.43054809205596 617 16414116
SGTC_2960 9079389 5.97 µM -0.175003722220987 0.430222276291861 no 1935 0.430538354406586 647 16457355
SGTC_320 4092-0846 5.34 µM -0.175367886481734 0.430074976359568 no 1936 0.430395286203666 618 1359356
SGTC_2286 7945697 125 µM -0.175396698208077 0.430063322788327 no 1937 0.430383967410442 636 1245733
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.176453352719017 0.429635976524187 no 1938 0.429968896369441 636 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3201 9113999 49.47 µM -0.177264405853347 0.42930801552777 no 1939 0.429650354005275 657 16649224
SGTC_1905 st060207 84.5 µM -0.177473651719173 0.429223411861576 no 1940 0.429568179793218 613 1948547
SGTC_1534 6-azauridine 81.6 µM -0.178955729983358 0.428624261505961 no 1941 0.42898623141041 623 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1381 2324-0066 62.1 µM -0.179572974602294 0.428374780378999 no 1942 0.428743911448916 656 10885928
SGTC_653 0203-0016 55.2 µM -0.179738565048655 0.42830785603995 no 1943 0.428678907961754 645 295302
SGTC_1270 0831-1170 17.3 µM -0.179796532810317 0.428284428520085 no 1944 0.428656152838832 621 6764716
SGTC_24 0417-1663 219 µM -0.180073872723006 0.428172345815692 no 1945 0.428547286922391 654 4329390
SGTC_774 k060-0086 136 µM -0.180371851060314 0.428051928863616 no 1946 0.428430325739042 674 5911235
SGTC_1279 0874-0590 65.2 µM -0.18041663658133 0.428033831026406 no 1947 0.428412747260904 625 3523074
SGTC_2666 tannic acid 100 µM -0.181145508316399 0.427739315132028 no 1948 0.428126682472678 628 16134267 A thiamine antagonist.
SGTC_2893 9048488 25.97 µM -0.182541766422785 0.427175240353051 no 1949 0.427578790032728 609 6467338
SGTC_3039 9090270 49.47 µM -0.184254936827532 0.426483339555978 no 1950 0.426906731901435 607 17173750
SGTC_54 0159-0055 9 µM -0.185131800499776 0.426129286639294 no 1951 0.426562829758708 697 3319099
SGTC_2242 6630449 61.2675 µM -0.18589014293976 0.425823137262406 no 1952 0.426265456136701 648 691249 YDR170C SEC7
SGTC_717 1532-0246 73.2 µM -0.186727871054823 0.425484991183494 no 1953 0.42593700124309 642 9561992
SGTC_447 ml7 120 µM -0.187841104929213 0.425035722987383 no 1954 0.425500606094862 632 4216 Selective myosin light chain kinase inhibitor.
SGTC_1834 st055981 52.8 µM -0.188072109647099 0.42494250850634 no 1955 0.425410062109783 664 471719 YDL150W RPC53
SGTC_2465 5809242 33.21 µM -0.188162342540116 0.424906099080801 no 1956 0.42537469573693 626 2731748
SGTC_903 1134-0042 114 µM -0.188823875767015 0.424639186684499 no 1957 0.42511542914753 623 701009
SGTC_370 0180-0345 38.7 µM -0.189309637460808 0.424443215774495 no 1958 0.424925071149443 631 3989527
SGTC_3354 9151612 71.43 µM -0.189535475507406 0.424352112255992 no 1959 0.424836576760635 645 27261949
SGTC_367 0335-0881 7.1 µM -0.189720083638043 0.42427764396983 no 1960 0.424764241082298 658 23828853
SGTC_2820 7989630 71.43 µM -0.190490472460497 0.423966909317812 no 1961 0.424462404188048 599 2984098
SGTC_2689 tacrolimus 100 µM -0.190590253277424 0.423926666396133 no 1962 0.424423313487497 626 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1714 st033236 13.627 µM -0.191820825192757 0.423430425832948 no 1963 0.423941278866626 658 2916566
SGTC_1134 3477-0009 42.5 µM -0.192078060042222 0.423326708598286 no 1964 0.423840530231998 603 3973534
SGTC_1744 st037937 38.9 µM -0.19276142053195 0.423051203090844 no 1965 0.423572909367666 659 1016152
SGTC_2611 pyromycin 23.93 µM -0.193419731592264 0.422785832161274 no 1966 0.423315131813519 625 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2765 myclobutanil 7.74 µM -0.194762405170333 0.422244697457164 no 1967 0.422789477480173 660 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1440 4100-1550 40 µM -0.196808499236832 0.421420347297871 no 1968 0.421988699885718 657 742806
SGTC_3220 9131269 49.47 µM -0.197041453181264 0.421326514324395 no 1969 0.421897549337812 629 17722206
SGTC_2459 5811157 9.22 µM -0.197926953027241 0.42096987912748 no 1970 0.421551107927805 619 2870684 YBR192W RIM2
SGTC_53 0973-0023 39.979 µM -0.198649705686844 0.420678838431663 no 1971 0.421268384431311 664 674768
SGTC_2144 5628481 200 µM -0.198807571565736 0.420615274182902 no 1972 0.4212066364839 617 2818399
SGTC_2 0422-0095 29 µM -0.199798836793226 0.42021619141637 no 1973 0.420818955545111 622 6790840
SGTC_2120 5538279 151.968 µM -0.200074210234712 0.420105340777812 no 1974 0.420711271406174 625 2058197
SGTC_34 0469-0683 81.75 µM -0.200196439907262 0.420056139670778 no 1975 0.420663475679812 633 3690923
SGTC_1497 4476-2978 41.3 µM -0.200696962408435 0.419854677401695 no 1976 0.42046776751944 618 1528379
SGTC_2956 9076196 2.52 µM -0.201073966539409 0.419702945624585 no 1977 0.420320368972603 661 16423868
SGTC_888 0916-0002 6.97 µM -0.203136875839139 0.418872904337442 no 1978 0.419514024898018 634 2802138 YIL048W NEO1
SGTC_1510 1123-0200 71.5 µM -0.203794192493859 0.418608499173612 no 1979 0.419257165663104 691 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2389 9091542 195.52 µM -0.205240721242479 0.418026763644488 no 1980 0.418692027811231 639 3626624 YOL127W RPL25
SGTC_1636 st007707 68.9 µM -0.207134681725415 0.417265360362253 no 1981 0.41795233864764 670 403051
SGTC_2288 7946289 167.31 µM -0.207780653927517 0.41700573969404 no 1982 0.417700119440186 673 1246052
SGTC_1565 sinapyl alcohol 95.1 µM -0.210145701309993 0.416055520504004 no 1983 0.416776978634835 642 5280507 A phenol propionate derived from cinnamic acid.
SGTC_769 0302-0231 76 µM -0.211624292991734 0.415461706725889 no 1984 0.416200077743628 649 571869 YER009W NTF2
SGTC_1318 1280-3875 124 µM -0.212127819918948 0.415259530434174 no 1985 0.416003658196941 664 373245
SGTC_907 3448-6986 75.5 µM -0.21218390455297 0.415237012701807 no 1986 0.415981781581388 662 590582
SGTC_570 0987-0065 62.6 µM -0.21236852347687 0.415162890987919 no 1987 0.415909770162671 622 3104428
SGTC_524 r073-0010 27.8 µM -0.213637178542508 0.414653626909914 no 1988 0.415415002190104 665 2772106
SGTC_2439 5492030 7.2 µM -0.214079831918034 0.414475970501842 no 1989 0.415242401505575 650 5722370
SGTC_1948 st076329 66.6 µM -0.214914853921958 0.414140886837319 no 1990 0.414916851863405 630 24208413
SGTC_2896 9052656 71.43 µM -0.217434570987653 0.413130136305361 no 1991 0.413934845920525 658 6469436
SGTC_1351 1496-0003 46.5 µM -0.217559039991063 0.413080222105317 no 1992 0.413886350675506 630 3891978
SGTC_314 1671-0008 2.74 µM -0.218026800648292 0.412892654646515 no 1993 0.413704114898092 668 3913060
SGTC_1383 3049-0032 20.7 µM -0.218066522201823 0.412876727606586 no 1994 0.413688640556921 670 712864
SGTC_413 propylparaben 100 µM -0.218852619869615 0.412561557765804 no 1995 0.413382427784761 650 7175 A pharmaceutical preservative.
SGTC_99 0109-0120 622.8 µM -0.218860133542876 0.412558545583265 no 1996 0.413379501197835 687 759414
SGTC_2905 7799065 20.05 µM -0.220230588627192 0.412009225393637 no 1997 0.412845787551923 685 1296806
SGTC_3320 9137005 35.139 µM -0.220317949303738 0.41197421440325 no 1998 0.412811771029982 650 4908713
SGTC_1005 4092-0690 4.4 µM -0.220545526012388 0.411883013203842 no 1999 0.412723160229508 661 1529343
SGTC_1842 st055362 61.2 µM -0.221601759150248 0.411459790930176 no 2000 0.412311956469023 627 676032
SGTC_2016 5121758 140 µM -0.222073874974019 0.411270652024117 no 2001 0.412128187421216 666 2795203
SGTC_3197 9113331 49.47 µM -0.223258334582884 0.410796225013661 no 2002 0.411667226514933 659 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_874 0599-0792 117 µM -0.223905258134669 0.410537159355387 no 2003 0.411415512100217 685 765305
SGTC_1414 3917-0015 5.4 µM -0.224705703783949 0.410216668588908 no 2004 0.411104113550772 651 6618702
SGTC_1310 1188-0297 994 nM -0.225032919039284 0.410085671989276 no 2005 0.410976832634041 648 1588352
SGTC_499 genistein 192 µM -0.225243368207018 0.410001426556191 no 2006 0.410894976600665 652 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1016 4226-1401 38 µM -0.225434832378349 0.409924784663212 no 2007 0.410820508317417 631 2901613
SGTC_1908 st060353 56.5 µM -0.227990727548566 0.408902006731893 no 2008 0.409826724527588 680 4227716
SGTC_2052 5265182 7.135 µM -0.228136718443693 0.40884360504409 no 2009 0.40976997773181 652 1239884
SGTC_3311 9131146 2.8755 µM -0.228721238378609 0.408609796016389 no 2010 0.409542793236857 651 4900406 YPR165W RHO1
SGTC_1101 ebselen 5.29 µM -0.229202954725495 0.408417133051824 no 2011 0.409355588084735 666 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2916 7875993 68.79 µM -0.229238805050125 0.408402795560782 no 2012 0.409341656716807 682 1299250
SGTC_1698 5-fluorocytosine 1.055 µM -0.230153769857574 0.408036918532735 no 2013 0.408986141929475 633 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1494 4358-1428 177 µM -0.231187288583452 0.407623730489156 no 2014 0.408584652391386 679 1564571
SGTC_485 niflumic acid 177 µM -0.231452129066975 0.407517867047732 no 2015 0.408481785611082 657 4488 A COX2 inhibitor.
SGTC_1505 k297-0037 20.6 µM -0.23270133949941 0.407018617214798 no 2016 0.407996664498395 641 4089396
SGTC_9 0092-0002 10.449 µM -0.233500895685315 0.406699151963313 no 2017 0.407686237059718 647 759368
SGTC_1474 0330-0125 5.35 µM -0.233716110167125 0.406613172918521 no 2018 0.407602689995255 642 X1474
SGTC_2391 6285546 200 µM -0.234244082577113 0.406402264909091 no 2019 0.407397746944039 637 846083
SGTC_2318 6029776 164 µM -0.23594225412211 0.405724084359341 no 2020 0.406738739820659 682 818325
SGTC_1165 k072-0275 30.3 µM -0.236325670599524 0.405571002505026 no 2021 0.406589984376418 639 6153523 YGL055W OLE1
SGTC_2866 9034245 58.44 µM -0.236622418365463 0.405452533685074 no 2022 0.406474863349666 658 6462273
SGTC_2010 4012422 159 µM -0.238840226458336 0.404567406503957 no 2023 0.405614738266535 662 952393
SGTC_2910 7948405 25.97 µM -0.239020862617813 0.404495336053584 no 2024 0.405544702756301 642 2971328
SGTC_2767 sibutramine 71.45 µM -0.240523290068903 0.403896021373746 no 2025 0.404962305122734 690 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2650 prasterone 100 µM -0.241491093042624 0.403510086445855 no 2026 0.404587259483248 652 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_824 1304-0008 100 µM -0.243015055820122 0.402902559859629 no 2027 0.403996867076855 651 768245
SGTC_2271 7849410 118.62 µM -0.243189920731197 0.402832865057799 no 2028 0.403929137308384 671 972430
SGTC_3003 9075612 71.4286 µM -0.2443542613759 0.402368879990905 no 2029 0.403478231154632 691 6501993
SGTC_466 geldanamycin 89.2 µM -0.244515859566658 0.402304494613849 no 2030 0.403415660263842 653 5288382 HSP90 inhibitor.
SGTC_403 arphamenine a 50 µM -0.245069354499013 0.402083986374914 no 2031 0.403201365527295 670 5487158 An arginine aminopeptidase inhibitor.
SGTC_2021 4019055 173 µM -0.245164231523853 0.402046191204847 no 2032 0.403164635231133 672 44827708 YER133W GLC7
SGTC_1540 guanosine 70.6 µM -0.245689263426517 0.401837056293791 no 2033 0.402961392021376 642 6802 Guanosine is a purine nucleoside
SGTC_2549 cedrol 20.94 µM -0.24610587600179 0.401671127833742 no 2034 0.402800137278818 645 6708665 A sedative which affects the nervous system.
SGTC_1337 1486-1011 40.3 µM -0.246459610292051 0.401530256450746 no 2035 0.402663233284889 647 X1337
SGTC_2137 5261020 140 µM -0.246821387911947 0.401386195122695 no 2036 0.402523228666976 656 763655
SGTC_218 alverine citrate 93.75 µM -0.247187163755547 0.401240555312071 no 2037 0.402381689482334 679 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2584 androsterone 48.74 µM -0.248490835110333 0.400721588344806 no 2038 0.401877330138561 669 2754130 A steroid.
SGTC_937 3122-0005 46.7 µM -0.24909717293453 0.400480276326724 no 2039 0.401642808110301 638 759535
SGTC_2145 5634607 200 µM -0.24998875769146 0.400125509948793 no 2040 0.401298021365457 680 308662
SGTC_2532 xanthone 78.9 µM -0.250014671799492 0.400115199816561 no 2041 0.401288001210401 678 7020 An insecticide.
SGTC_1627 st003713 25.6 µM -0.250589498191863 0.399886518515613 no 2042 0.401065750970034 645 16195070 YER133W GLC7
SGTC_1109 tnp00067 928.257 nM -0.250643719594241 0.399864949563374 no 2043 0.401044788518132 648 676295
SGTC_3254 9136651 49.47 µM -0.25371575006163 0.39864341498274 no 2044 0.399857582666616 668 16454030
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.254249817732953 0.398431154027671 no 2045 0.39965128288022 659 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1008 4106-0037 6 µM -0.254432472160407 0.398358566367977 no 2046 0.399580733510142 701 2905394
SGTC_169 k015-0017 16.025 µM -0.255345497521266 0.397995778913115 no 2047 0.39922813117424 715 1840002
SGTC_1715 st032160 10.2275 µM -0.256870240134074 0.397390124454416 no 2048 0.398639472419285 686 5289825
SGTC_2390 9097792 176.6 µM -0.25754312063286 0.39712292310402 no 2049 0.398379766071823 657 4497149
SGTC_142 0335-0849 62.6745 µM -0.25887533704536 0.396594041503697 no 2050 0.39786571392946 640 3889043 YPR107C YTH1
SGTC_2005 4024620 188 µM -0.258908812770787 0.396580754295217 no 2051 0.397852799187124 676 236743
SGTC_163 TUB2.036 7.546 µM -0.25975031676927 0.39624678342926 no 2052 0.397528188592706 638 15992207 YJR013W GPI14
SGTC_1805 st050013 60.3 µM -0.260451556376656 0.395968537959005 no 2053 0.397257739242496 673 4037144
SGTC_3070 9117005 49.47 µM -0.260489737534848 0.395953389544325 no 2054 0.397243015208261 663 8779016
SGTC_1274 0865-0114 173 µM -0.260576962986105 0.395918783344338 no 2055 0.397209378471901 645 870624
SGTC_2773 thioridazine 9.09 µM -0.261401889575228 0.395591539030003 no 2056 0.396891300006289 648 5452 An antipsychotic.
SGTC_1779 st039427 55 µM -0.261938692199372 0.395378631585377 no 2057 0.39668435434371 696 1124498
SGTC_2561 acetosyringone 100 µM -0.262119093222433 0.395307087673537 no 2058 0.396614813505934 660 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1076 itraconazole 331 nM -0.263529005536506 0.394748062677751 no 2059 0.396071435108335 642 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_810 3825-7150 143 µM -0.263591404131166 0.394723326864491 no 2060 0.396047391427052 654 22330411 YGL099W LSG1
SGTC_3224 9130643 49.47 µM -0.264500242959006 0.39436309659331 no 2061 0.395697238810174 698 17644395
SGTC_3230 9131665 49.47 µM -0.26748721785682 0.39317980748377 no 2062 0.394547027211352 674 15943720
SGTC_1360 1598-0022 39.8 µM -0.269640252694435 0.392327494384408 no 2063 0.39371851487576 688 761525
SGTC_2170 morpholine 200 µM -0.269974706993398 0.392195141551487 no 2064 0.393589856110412 670 121171 Reacts with secondary amines.
SGTC_1447 4239-0816 81.9 µM -0.270189459687401 0.392110164533826 no 2065 0.393507250598807 670 1341554
SGTC_2806 7952793 58.44 µM -0.270258053137074 0.392083023388915 no 2066 0.393480866854575 655 2972490
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.270592040132633 0.39195087848707 no 2067 0.393352409283152 679 4174840
SGTC_2199 6590217 200 µM -0.270761862757837 0.391883691445495 no 2068 0.393287096813935 661 703109
SGTC_2769 toremifene 3.73 µM -0.271748841530663 0.391493276235405 no 2069 0.392907571905863 657 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_133 0724-0033 378.92 µM -0.271749311137148 0.391493090501041 no 2070 0.392907391351346 659 280309
SGTC_3295 9122362 53.5725 µM -0.272011353164766 0.391389453949085 no 2071 0.392806644907006 691 4730473
SGTC_428 3448-4153 16.5 µM -0.272190327531999 0.391318674748174 no 2072 0.392737839342049 650 3834874
SGTC_3046 9092212 49.47 µM -0.272950914463624 0.391017924719275 no 2073 0.392445473913798 642 25236637
SGTC_3012 9080433 71.4286 µM -0.273185303836722 0.390925255986744 no 2074 0.39235538815532 673 17688859
SGTC_2716 st080858 38.6235 µM -0.273590481144226 0.390765078744833 no 2075 0.392199674970186 662 5296050
SGTC_3088 9117578 49.47 µM -0.275010073475397 0.390204022956233 no 2076 0.391654249545053 654 678341
SGTC_2872 9044037 25.97 µM -0.276166371691341 0.389747195986687 no 2077 0.391210142347448 655 6465195
SGTC_930 2810-3379 265 µM -0.27739811751229 0.389260728898527 no 2078 0.39073721347037 714 1015764
SGTC_1726 st035556 14.5795 µM -0.278773067055954 0.388717909735161 no 2079 0.39020949237815 686 5919439
SGTC_943 3253-1379 105 µM -0.278835099584867 0.388693424898231 no 2080 0.390185688357161 701 668464
SGTC_2602 kawain 100 µM -0.281556319690621 0.387619769549698 no 2081 0.38914186872057 675 5369129
SGTC_1981 st071826 47 µM -0.282135126955502 0.387391512059871 no 2082 0.388919949710818 653 11838600
SGTC_795 0685-0265 78 µM -0.282372452666608 0.387297931926295 no 2083 0.388828967739472 663 302754
SGTC_2325 6158266 200 µM -0.282431463378261 0.387274664371205 no 2084 0.388806346143713 657 3623240
SGTC_2340 7987427 183.45 µM -0.283246376005694 0.386953390856032 no 2085 0.388493990189627 678 2239331
SGTC_2988 9073640 71.4286 µM -0.283461081873161 0.386868757473076 no 2086 0.388411705436538 696 9102229
SGTC_546 peri-Naphthalide 147 µM -0.283462381749066 0.386868245100592 no 2087 0.388411207282037 653 223824 A penicillin ester.
SGTC_1393 3470-5649 58.2 µM -0.283474603425933 0.38686342768811 no 2088 0.38840652354904 687 4108395
SGTC_2936 9038235 15.59 µM -0.284595832319448 0.386421547675768 no 2089 0.387976902299605 654 4749415
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.285995007144325 0.385870334832289 no 2090 0.387440972819935 659 88881 An O-methylated flavonoid and antioxidant.
SGTC_3038 9091290 49.47 µM -0.289820647083949 0.384364381303974 no 2091 0.385976725688622 701 25236843
SGTC_1410 3909-8106 77.9 µM -0.289911858603348 0.384328497312625 no 2092 0.38594183460048 680 1039210
SGTC_288 1315-0019 35.1 µM -0.292515811721378 0.383304482005503 no 2093 0.38494613614254 675 6811474
SGTC_3013 9080133 71.4286 µM -0.292942400972207 0.383136801505679 no 2094 0.384783089240266 671 17050193
SGTC_2396 5342950 42.78 µM -0.29352249841718 0.38290881629139 no 2095 0.384561402586075 666 1886677
SGTC_3218 9131285 49.47 µM -0.293657929633828 0.382855596045179 no 2096 0.384509652414664 711 17156417
SGTC_951 1171-0579 82.7 µM -0.294903728636837 0.382366139736535 no 2097 0.384033711757295 684 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1003 4049-0218 100 µM -0.294953231177316 0.382346694784482 no 2098 0.384014803588243 668 295161
SGTC_1904 st060225 78 µM -0.297968945910209 0.381162661770114 no 2099 0.382863432602606 650 66595
SGTC_1235 benzylparaben 21.5 µM -0.298487633620572 0.380959125802912 no 2100 0.38266550657002 693 7180
SGTC_350 k064-0020 19.8 µM -0.30090271299502 0.38001186960249 no 2101 0.381744340734841 686 2790705
SGTC_2093 5331342 194.4 µM -0.302522357180981 0.37937700613505 no 2102 0.381126946418434 680 33839
SGTC_2585 alliin 100 µM -0.30299537389112 0.379191655671642 no 2103 0.380946693546544 716 87310 A garlic compound which reacts with lipids.
SGTC_2953 9074162 66.49 µM -0.304348652281938 0.378661530281302 no 2104 0.380431141419906 662 16451992
SGTC_582 0987-0078 156 µM -0.304747773348259 0.378505224458482 no 2105 0.380279130638438 687 1625765
SGTC_1391 3442-0225 151 µM -0.305082929149283 0.378373984389648 no 2106 0.380151496193616 658 5227075
SGTC_2845 9003024 42.97 µM -0.306471310512544 0.377830472594867 no 2107 0.379622910238843 668 2990173
SGTC_3331 9141060 1.957 µM -0.306602409281474 0.377779163633072 no 2108 0.379573009787717 683 4906567 YPR165W RHO1
SGTC_2347 9049783 174.81 µM -0.309689494963435 0.376571576262759 no 2109 0.378398546056581 732 6467988 YPL169C MEX67
SGTC_1172 0370-0043 85 µM -0.309736697485283 0.376553121206059 no 2110 0.378380596818167 685 376585
SGTC_3283 9109332 35.8195 µM -0.312064656938789 0.37564329564111 no 2111 0.377495692929186 676 17027281
SGTC_3156 9099931 49.47 µM -0.312228773398422 0.375579180787369 no 2112 0.377433333182915 660 18111053
SGTC_2293 7624732 200 µM -0.313060306106488 0.375254381397463 no 2113 0.377117422738155 679 894453
SGTC_425 3825-7017 13.1 µM -0.313828036899388 0.374954581741085 no 2114 0.376825824498886 708 3397440
SGTC_2337 9009472 200 µM -0.314976328885441 0.374506313588603 no 2115 0.376389813295537 697 5742383
SGTC_2455 5377712 9.75 µM -0.315467301807094 0.374314700178478 no 2116 0.376203436941495 656 2243908
SGTC_2217 6934799 96.0675 µM -0.315981122780356 0.374114203035114 no 2117 0.376008418237573 695 675606
SGTC_1914 st062367 72.6 µM -0.317545063622779 0.373504150273675 no 2118 0.375415025753235 699 978205
SGTC_1798 st045719 60.953 µM -0.318569016557342 0.373104904334027 no 2119 0.375026675701007 664 3980186
SGTC_2352 9027995 87.8 µM -0.31857793602042 0.373101427174964 no 2120 0.375023293412042 675 2997347
SGTC_3234 9132280 49.47 µM -0.318869722509672 0.372987682976057 no 2121 0.374912652342126 677 17612295
SGTC_2977 9011197 71.43 µM -0.319416311328318 0.372774641542192 no 2122 0.374705421750995 708 2704722
SGTC_1371 2421-0008 32.7 µM -0.321272183673358 0.37205157732236 no 2123 0.374002067097107 696 2827552
SGTC_1160 4092-0570 10.5 µM -0.323642353898858 0.371128794095751 no 2124 0.373104409259417 671 4994975
SGTC_1320 1313-0481 95.3 µM -0.323778962461291 0.371075630523224 no 2125 0.373052692246431 709 6813365 YLR208W SEC13
SGTC_1309 pyrazolanthrone 13.4 µM -0.324225028828762 0.370902053259869 no 2126 0.372883837212449 682 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1065 prochlorperazine maleate 2.48 µM -0.325265273379806 0.370497366266925 no 2127 0.372490155467242 700 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_334 1502-1024 68.5 µM -0.325279339040888 0.370491895274628 no 2128 0.372484833213375 714 3296216
SGTC_1148 3909-7663 27.7 µM -0.326558574297486 0.369994432414337 no 2129 0.372000890012978 721 4084526
SGTC_1303 1160-0052 261 µM -0.327450294809747 0.369647792983263 no 2130 0.371663665727839 690 3562476
SGTC_3060 1327-0027 12.5 µM -0.329232820094016 0.368955187807864 no 2131 0.37098985881095 679 16000455 YPR107C YTH1
SGTC_2707 st078556 66.6 µM -0.3328604585544 0.367546974360387 no 2132 0.369619809250698 681 17250899
SGTC_3216 9129716 49.47 µM -0.333254300754515 0.367394195434022 no 2133 0.369471166144289 673 8056934
SGTC_3294 9122953 26.2835 µM -0.335272071057732 0.366611793412139 no 2134 0.368709929900852 691 16459826
SGTC_2873 9040596 71.43 µM -0.336142986923935 0.366274261738161 no 2135 0.368381521800318 752 6463863
SGTC_972 1319-0219 195 µM -0.337574815289786 0.365719568034047 no 2136 0.367841811823384 704 23903702
SGTC_1873 rapamycin 2 nM -0.338850706367654 0.365225521213645 no 2137 0.36736110019313 686 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2452 5863136 48.41 µM -0.341638202184805 0.364146934054063 no 2138 0.366311591994278 701 2184096
SGTC_1435 4092-0789 56.7 µM -0.343389330397082 0.363469905846184 no 2139 0.365652792608553 697 2248285
SGTC_1273 0849-0096 14.1 µM -0.343580615284461 0.363395976300558 no 2140 0.365580852469159 716 5286025
SGTC_2556 citropten 84.59 µM -0.343745150903209 0.363332389128889 no 2141 0.365518976217389 672 2775 A potential DNA crosslinker.
SGTC_1718 roemerine 11.9335 µM -0.343832486156161 0.363298638686001 no 2142 0.36548613381994 706 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1631 benzylvanillin 81.9 µM -0.344917258243654 0.36287952034254 no 2143 0.365078287847916 700 75506
SGTC_3018 9082602 49.47 µM -0.346455173354997 0.362285604736998 no 2144 0.364500333516313 692 17332089
SGTC_75 0159-0059 199.013 µM -0.348011326035318 0.361684983340207 no 2145 0.363915838802609 729 5377270
SGTC_2283 7944793 200 µM -0.34845488697826 0.36151384638968 no 2146 0.363749294140009 673 2970533
SGTC_1468 k284-1086 134 µM -0.348802149598975 0.361379883081424 no 2147 0.363618924752154 699 15996457
SGTC_2378 9074213 121.43 µM -0.350359692485064 0.360779239882987 no 2148 0.363034386189974 684 657714
SGTC_400 oxethazaine 37.5 µM -0.350650531250541 0.360667120235023 no 2149 0.362925271057056 711 4621 A local anesthetic.
SGTC_2186 6124449 200 µM -0.351180044221266 0.360463021367309 no 2150 0.362726640153232 696 3834182 YLR033W RSC58
SGTC_2907 7721985 69.9 µM -0.351636761748855 0.36028701316741 no 2151 0.362555345939778 688 3267881
SGTC_2959 9079155 11 µM -0.352784251132534 0.35984492844087 no 2152 0.36212509570167 729 16189457
SGTC_2614 arthonioic acid 13.39 µM -0.353099335066551 0.359723571164642 no 2153 0.362006985680951 712 6710684
SGTC_648 0375-0473 33.3 µM -0.353106941791323 0.359720641544224 no 2154 0.362004134443059 712 1713139
SGTC_676 falcarinol 140 µM -0.353173067067799 0.359695174694277 no 2155 0.361979348947972 737 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1863 st057641 20.1 µM -0.353322491890642 0.359637628956719 no 2156 0.361923342721125 701 3921635
SGTC_3133 9127736 49.47 µM -0.35347528201873 0.35957879048044 no 2157 0.361866078194685 702 27243420
SGTC_3185 9108267 49.47 µM -0.354687465891306 0.359112104486082 no 2158 0.361411871000531 715 4910486
SGTC_43 0570-0105 72.5 µM -0.354754849876088 0.359086168078347 no 2159 0.361386627838917 718 1114046 YDL195W SEC31
SGTC_2331 7980721 200 µM -0.35519324643778 0.358917443075165 no 2160 0.361222411932405 687 2981221
SGTC_2361 9034121 116 µM -0.355619361433457 0.3587534712343 no 2161 0.361062820996235 712 6496917
SGTC_2080 5212524 12.4 µM -0.356126861895319 0.358558215695021 no 2162 0.360872780679573 708 260183
SGTC_1315 1237-0019 3.69 µM -0.356915792231933 0.358254756346467 no 2163 0.360577423400357 697 825140
SGTC_1011 4112-3381 17.4 µM -0.357023230290652 0.358213437586311 no 2164 0.360537207504616 725 2877139
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.357072965728043 0.358194310786814 no 2165 0.360518591205388 702 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_327 1273-0057 3.96 µM -0.357302849908006 0.358105908656444 no 2166 0.360432548350839 711 3108138
SGTC_2867 9039098 71.43 µM -0.360172928226548 0.357002859655823 no 2167 0.359358909097082 691 6463460
SGTC_152 4469-0003 551.229 µM -0.36222059368336 0.356216615604882 no 2168 0.358593595725143 716 697280
SGTC_838 0109-0203 71.4 µM -0.363536560848659 0.355711644669406 no 2169 0.35810205335856 691 759422
SGTC_1057 3448-5381 134 µM -0.363888330794769 0.355576704197581 no 2170 0.357970699421375 698 5497911
SGTC_1133 3473-0247 50 µM -0.364005652928841 0.355531702943897 no 2171 0.357926894060952 715 711311
SGTC_2654 protoveratrine a 100 µM -0.364204054280655 0.355455606715365 no 2172 0.357852819860357 716 5702278 A heart drug and vasodilator.
SGTC_167 3672-0051 66.205 µM -0.364475197297225 0.355351619963258 no 2173 0.357751595828179 703 3237971
SGTC_1032 k061-1018 98.7 µM -0.365707753095805 0.354879055172381 no 2174 0.357291580092509 734 4005393
SGTC_415 dibenzyl ketone 100 µM -0.366367706928768 0.354626119017544 no 2175 0.357045356626081 723 7593
SGTC_1289 0976-0073 69.1 µM -0.367071824707414 0.354356327099044 no 2176 0.356782721583684 729 3391136
SGTC_321 4534-3890 65.3 µM -0.368239747174184 0.353908983533547 no 2177 0.356347237691279 708 699746
SGTC_2939 9044578 71.43 µM -0.368987091488915 0.353622837670808 no 2178 0.35606867321947 696 2653634
SGTC_1464 k208-0027 110 µM -0.369707432205455 0.35334710930114 no 2179 0.355800246737658 724 X1464
SGTC_1082 camptothecin 424.86 nM -0.370005794184168 0.353232926344351 no 2180 0.355689086588193 694 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1064 honokiol 6.76 µM -0.371234309500658 0.352762913530451 no 2181 0.355231510373354 716 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_916 4466-0038 42 nM -0.371495918721704 0.352662854481133 no 2182 0.35513409760364 722 5722064 YGL116W CDC20
SGTC_457 grayanotoxin iii 135 µM -0.371866103722806 0.352521285300763 no 2183 0.354996271749949 716 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2150 5556613 200 µM -0.372069045399104 0.352443683349544 no 2184 0.354920721336899 707 743190
SGTC_725 1497-0963 19 µM -0.373541148328617 0.35188095659185 no 2185 0.35437286297453 715 3549977
SGTC_1211 1056-0033 32.3 µM -0.374146563165592 0.351649624468681 no 2186 0.354147638911263 727 6741922
SGTC_2596 sinensetin 100 µM -0.374790064874337 0.351403799369683 no 2187 0.353908301845521 693 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1789 tunicamycin 25 nM -0.375392105903483 0.351173868992172 no 2188 0.353684437472619 731 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_262 fenpropimorph 62.5 µM -0.375579894412745 0.351102160298599 no 2189 0.353614620092596 723 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2479 5617353 43.85 µM -0.377591541678446 0.350334328147092 no 2190 0.352867024544102 734 2731746
SGTC_1489 4065-0444 182 µM -0.37937918764607 0.349652508573981 no 2191 0.352203151655363 710 2877968
SGTC_2051 5263410 176 µM -0.380878601142747 0.349080996329805 no 2192 0.351646665825801 710 227584
SGTC_2781 5567276 71.43 µM -0.381134158990831 0.348983622707147 no 2193 0.351551850853832 734 2853274
SGTC_899 1083-0020 478 µM -0.381607779826592 0.348803188190419 no 2194 0.351376156365017 747 767123
SGTC_3329 9141233 27.5565 µM -0.382579859064767 0.348432963966982 no 2195 0.351015653136758 742 4909101 YNL103W MET4
SGTC_976 1348-1067 47.6 µM -0.390539193337327 0.345407044735322 no 2196 0.348068939729 704 5310671 YGL099W LSG1
SGTC_778 3456-2434 196 µM -0.39114572135675 0.345176861190646 no 2197 0.347844763278671 711 5539063
SGTC_2109 5483026 200 µM -0.391295611628854 0.345119985131289 no 2198 0.347789371113095 739 759335
SGTC_2491 paeonol 100 µM -0.391985173362541 0.344858375116664 no 2199 0.347534584450246 723 11092 Increases levels of cortical cytochrome oxidase.
SGTC_296 1222-0039 74.9 µM -0.392750537000212 0.344568093758121 no 2200 0.347251870320885 721 5984176
SGTC_1493 4348-0038 111 µM -0.392910567033766 0.344507410332952 no 2201 0.347192768303915 723 800424
SGTC_718 1130-0073 349 µM -0.393144277597805 0.344418794423792 no 2202 0.347106461396758 731 6740020
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.393903185166794 0.344131098755328 no 2203 0.346826259340356 740 689007
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.394853964902298 0.343770793205611 no 2204 0.346475332901034 706 5106787 A p450 inhibitor.
SGTC_2744 captopril 92.04 µM -0.396514547677832 0.343141842535673 no 2205 0.345862738996686 717 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_3000 9075062 71.4286 µM -0.39777276110782 0.342665579526994 no 2206 0.345398848766589 702 17057871
SGTC_796 1234-0020 70.7 µM -0.397987793311115 0.342584209835049 no 2207 0.345319591832339 687 46495034
SGTC_753 1322-0200 289 µM -0.398161933029572 0.342518319498385 no 2208 0.345255412089806 729 5403907
SGTC_2112 5488546 200 µM -0.401778941217142 0.341150815546533 no 2209 0.343923360836011 750 600757
SGTC_2248 tofa 1.1 µM -0.402713555737959 0.34079779829438 no 2210 0.343579480209512 712 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_15 0266-0086 27.098 µM -0.402720674897217 0.340795109820739 no 2211 0.343576861293317 740 1712902 YIL048W NEO1
SGTC_605 1315-0399 119 µM -0.40548060745568 0.339753461475671 no 2212 0.342562135135102 718 24020461
SGTC_1249 0481-0015 10.2 µM -0.405920050542454 0.339587720348251 no 2213 0.342400672574169 726 4227577
SGTC_3001 9076041 71.4286 µM -0.406577515019692 0.339339807813204 no 2214 0.342159157195566 711 16004211
SGTC_2568 diosmetin 100 µM -0.408544464027866 0.33859853863719 no 2215 0.341436996815935 769 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_882 0843-0131 351 µM -0.408589145564056 0.33858170709265 no 2216 0.341420598831854 707 5425421
SGTC_553 k007-0256 45.7 µM -0.408976265465517 0.338435892441152 no 2217 0.341278539574002 734 6287000
SGTC_2880 9042983 58.44 µM -0.409001408785361 0.338426422661347 no 2218 0.341269313646002 748 6464714
SGTC_232 clozapine 119 µM -0.409035767157008 0.338413482363016 no 2219 0.341256706559595 708 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1132 3456-3614 2.5 µM -0.410108018572543 0.338009739249798 no 2220 0.340863355418096 736 3125502
SGTC_156 3474-0145 5.642 µM -0.410440009754946 0.337884769785724 no 2221 0.340741600824722 741 2265471
SGTC_1255 0566-0045 221 µM -0.41151977187611 0.337478444974941 no 2222 0.340345723162885 720 2788469
SGTC_1087 pterostilbene 9.05 µM -0.411832241050041 0.337360895156158 no 2223 0.340231194088312 727 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2285 7945142 200 µM -0.412218506883189 0.337215605229036 no 2224 0.340089636753706 757 2970608
SGTC_2920 7982904 15.77 µM -0.412983359937436 0.336927985243133 no 2225 0.339809402629723 734 6456808
SGTC_1152 3909-8331 15.9 µM -0.415054484172388 0.336149626060802 no 2226 0.339051009166077 719 16001939
SGTC_608 k048-0125 159 µM -0.415112917217049 0.336127676223059 no 2227 0.339029621898105 748 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1469 k284-2957 126 µM -0.415549297977643 0.335963771460788 no 2228 0.338869917169813 722 23884841
SGTC_144 4161-2749 112.381 µM -0.416462403247835 0.335620909749683 no 2229 0.33853583660378 712 797501 YMR168C CEP3
SGTC_837 0091-0265 12.5 µM -0.418030511102626 0.335032420590967 no 2230 0.33796240477392 723 759367
SGTC_2653 dihydrofissinolide 100 µM -0.418851580327779 0.334724446040196 no 2231 0.337662302775008 716 6857746
SGTC_422 cantharidin 155 µM -0.41911686174197 0.334624965479397 no 2232 0.337565364079027 713 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2798 7813637 45.45 µM -0.419301772694136 0.33455563071614 no 2233 0.337497800598421 759 956368
SGTC_1686 st019653 115.5 µM -0.419520417935821 0.334473654122636 no 2234 0.337417917911329 758 97252
SGTC_743 1275-0778 158 µM -0.422929884905279 0.333196366832232 no 2235 0.336173208971367 719 2849257 YMR203W TOM40
SGTC_2911 7942208 15.64 µM -0.423123187646762 0.333124007646071 no 2236 0.336102692712252 717 1243384
SGTC_219 mitoxanthrone 164.414 µM -0.424124745703187 0.33274919305794 no 2237 0.335737419747461 741 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1660 st012960 28.1 µM -0.424731061187894 0.332522371865703 no 2238 0.335516368981791 755 24207266
SGTC_256 clotrimazole 625 nM -0.425170949806245 0.332357848940141 no 2239 0.335356029819438 706 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2952 9073731 13.78 µM -0.425213504887079 0.332341934609468 no 2240 0.335340520105891 742 16457353
SGTC_1604 st002052 72.4 µM -0.425235721226734 0.332333626481317 no 2241 0.335332423203889 701 6254834 YHR062C RPP1
SGTC_1931 st074438 57.1 µM -0.425819860416117 0.332115208581404 no 2242 0.335119557004342 768 2787313
SGTC_2551 apiole 73.87 µM -0.426258258486551 0.331951322798673 no 2243 0.334959835108103 707 10659 A possible DNA adduct former.
SGTC_3338 9144300 39.5675 µM -0.427680988221591 0.331419687156824 no 2244 0.33444169663866 728 4901274
SGTC_503 tyrphostin 8 294 µM -0.427867680112386 0.33134995061961 no 2245 0.334373729411171 769 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1010 4112-3296 15.2 µM -0.428292415351926 0.331191317605996 no 2246 0.334219120124088 732 704384
SGTC_3175 9106517 49.47 µM -0.428981228420413 0.330934119408786 no 2247 0.333968442784157 748 41468073
SGTC_920 mycophenolic acid 780.421 nM -0.43026918020346 0.330453420922792 no 2248 0.333499921761571 724 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1499 4480-0877 67.3 µM -0.431203625798834 0.330104835482757 no 2249 0.333160158896015 726 2861909
SGTC_1280 0880-0253 10.1 µM -0.431494171735062 0.329996480305348 no 2250 0.333054544760681 753 6836607
SGTC_313 3474-0040 5.03 µM -0.432539036996334 0.329606929848777 no 2251 0.332674843238522 742 1043375 YIL048W NEO1
SGTC_1707 st032323 6.317 µM -0.433312033044551 0.329318857561368 no 2252 0.332394048727748 736 3132057 YMR211W DML1
SGTC_2250 alverine citrate 130 µM -0.433543915990308 0.32923246153112 no 2253 0.332309834468166 726 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_741 4582-0002 126 µM -0.436655119901665 0.328074158151508 no 2254 0.331180740960006 705 2912688
SGTC_1208 2323-2347 50.3 µM -0.437344513057815 0.327817719718217 no 2255 0.330930758999383 742 5412760
SGTC_1426 4048-4480 71.7 µM -0.438281902377731 0.32746916264127 no 2256 0.330590971667687 732 14224343
SGTC_1304 1165-0502 251 µM -0.438507377353373 0.327385344870273 no 2257 0.330509261723121 713 767425
SGTC_1174 0739-0097 51.1 µM -0.438665143811453 0.327326702148538 no 2258 0.330452093492344 732 728447
SGTC_1081 sertraline 6 µM -0.439296882954384 0.327091923695157 no 2259 0.33022321623889 743 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_995 3931-2021 34.6 µM -0.440813950698457 0.326528402762763 no 2260 0.329673846528769 745 730143
SGTC_1653 st012112 65 µM -0.440982071396002 0.326465977979494 no 2261 0.329612988235714 749 720429
SGTC_3 0833-0587 95.581 µM -0.444273828427904 0.325244698818979 no 2262 0.328422310313779 726 5382644
SGTC_1072 oxiconazole 14.9 nM -0.444386945333543 0.325202764409556 no 2263 0.328381425096291 721 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_3040 9091894 49.47 µM -0.446011104488709 0.32460090457785 no 2264 0.327794612324815 717 25236966
SGTC_2369 9071472 200 µM -0.446330454205257 0.324482617903971 no 2265 0.327679280423077 718 17296037
SGTC_3172 9105863 49.47 µM -0.447685982124737 0.323980729512584 no 2266 0.327189919893122 735 2348785
SGTC_2255 7941087 197.44 µM -0.448151695831832 0.323808371339969 no 2267 0.327021860592119 737 935561
SGTC_2587 piperic acid 92.2 µM -0.448842962043205 0.323552607040409 no 2268 0.326772472190089 736 5370536
SGTC_1607 st000305 50.6 µM -0.45056741305376 0.322914934087846 no 2269 0.326150678708676 764 5457690
SGTC_1899 st063254 59.6 µM -0.453092216504076 0.321982243029234 no 2270 0.325241169919307 738 3093813
SGTC_1575 cyproterone acetate 48 µM -0.45396120527215 0.321661487542784 no 2271 0.324928374800684 772 9880 An androgen receptor antagonist and liver toxin.
SGTC_1231 0242-0792 125 µM -0.4540960866305 0.321611712920427 no 2272 0.324879834906247 760 3707635
SGTC_644 1498-1197 63.3 µM -0.454332084365206 0.321524631508557 no 2273 0.324794913308321 743 6741615
SGTC_1581 himbacine 57.9 µM -0.455452402321738 0.321111376345945 no 2274 0.324391901540304 765 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1974 st069448 26.9 µM -0.455832805255078 0.320971106271392 no 2275 0.324255105998889 739 6323587 YNR016C ACC1
SGTC_2218 6965428 192.983 µM -0.455913147156647 0.320941484202822 no 2276 0.324226217525264 734 675684
SGTC_268 camptothecin 39.6153 µM -0.456066551631185 0.320884927120722 no 2277 0.324171060939601 760 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3166 9102297 49.47 µM -0.456620390619743 0.320680772646895 no 2278 0.323971960228032 749 25237072
SGTC_514 4466-0038 2.65 nM -0.456863381094947 0.320591219334893 no 2279 0.323884622971555 743 5722064
SGTC_2526 patulin 37.61 µM -0.457161451191596 0.320481380877514 no 2280 0.323777501871349 743 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2830 7992007 71.43 µM -0.457984976328303 0.320177994639744 no 2281 0.323481617454376 748 1952075
SGTC_1815 st051655 58.2 µM -0.45826276923443 0.320075682972964 no 2282 0.323381834375665 750 5984156
SGTC_282 k297-0036 65.7 µM -0.459505190543253 0.319618264305701 no 2283 0.322935712764535 744 5061378
SGTC_1917 st066507 28.5 µM -0.460814830082997 0.319136395004422 no 2284 0.322465730475661 730 3156428
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.46082706202694 0.319131895816491 no 2285 0.322461342208695 738 442882
SGTC_3129 9127257 49.47 µM -0.461624097094755 0.318838785594539 no 2286 0.32217545550085 773 837894
SGTC_673 1082-0474 110 µM -0.461934469682596 0.318724676485254 no 2287 0.322064157100875 766 3098046
SGTC_1168 k815-0004 80.5 µM -0.462599946536715 0.318480070513091 no 2288 0.321825573488715 726 642433
SGTC_353 1988-1175 58.3 µM -0.462744231472265 0.318427046857247 no 2289 0.321773854820756 758 2788357
SGTC_2811 7967822 32.47 µM -0.464049864271216 0.317947405580754 no 2290 0.321306010260439 723 2232244
SGTC_2571 chrysanthemic acid 100 µM -0.464932359668754 0.317623382182896 no 2291 0.320989948064018 793 2743 An insecticide.
SGTC_3082 9117008 49.47 µM -0.465539803359239 0.317400429889018 no 2292 0.320772469861036 735 41448529
SGTC_2140 5586273 200 µM -0.465604409452506 0.317376721172168 no 2293 0.320749343075266 745 854421
SGTC_371 0195-0006 7.36 µM -0.46728723208707 0.316759434222253 no 2294 0.320147195037626 733 3928593
SGTC_249 wiskostatin 11.211 µM -0.468171180748617 0.316435391478185 no 2295 0.319831089821096 744 2775510 A n-wasp and actin depolymerizer.
SGTC_2801 7907800 81.82 µM -0.470364071973972 0.315632118028983 no 2296 0.319047464182653 775 6620925
SGTC_687 k029-0044 34.9 µM -0.470929461524319 0.315425152311415 no 2297 0.318845554147006 757 5829338
SGTC_2142 5622915 118.518 µM -0.47115374227763 0.315343068443368 no 2298 0.318765474638308 723 5322196
SGTC_3280 9140961 49.47 µM -0.471596751974896 0.315180959379999 no 2299 0.318607322762847 758 4901226
SGTC_3071 9117417 49.47 µM -0.472007462753747 0.315030701137361 no 2300 0.318460730924822 740 45595590 YGL055W OLE1
SGTC_1216 1165-0504 9.65 µM -0.472227671629749 0.314950150480566 no 2301 0.318382145165894 751 6304004
SGTC_2970 9090938 41.86 µM -0.472272060271162 0.314933914534028 no 2302 0.318366305217769 715 17217104
SGTC_1756 st041558 35.5 µM -0.47267187987766 0.314787689419811 no 2303 0.318223645807645 779 3955792
SGTC_1089 terbinafine 2.25 µM -0.47348921095829 0.314488859147096 no 2304 0.317932098262918 747 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_871 0574-0004 149 µM -0.481133443431566 0.311699900135114 no 2305 0.315210830193573 758 9551173
SGTC_1796 st049173 110.4 µM -0.481978720142405 0.311392163504894 no 2306 0.3149105315806 781 94134
SGTC_2195 6536160 144.242 µM -0.482153310811803 0.311328617362285 no 2307 0.314848520577027 733 3834386
SGTC_2008 4012253 172 µM -0.485687776702356 0.310043381173644 no 2308 0.313594275677291 730 603940
SGTC_2257 7960413 200 µM -0.485981616471399 0.309936636486672 no 2309 0.313490100028691 745 2974689 YIL048W NEO1
SGTC_3043 9092303 49.47 µM -0.486107487991649 0.309890915391452 no 2310 0.313445479076932 745 25236084
SGTC_2191 5911152 200 µM -0.486274962247425 0.309830087234372 no 2311 0.313386114354304 747 2875902
SGTC_2232 chlorophetanol 41.5365 µM -0.487156810374483 0.309509877971766 no 2312 0.313073604777428 754 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2091 4-phenylthiadiazole 200 µM -0.487526028390782 0.309375853554959 no 2313 0.312942801050416 750 270010
SGTC_839 0122-0028 230 µM -0.487532781366342 0.309373402492404 no 2314 0.312940408877224 782 759448
SGTC_863 0466-0191 129 µM -0.48782398994198 0.309267713388146 no 2315 0.312837258682698 772 765160 YPR165W RHO1
SGTC_2486 5283202 22.39 µM -0.487993350398461 0.309206254202973 no 2316 0.312777275552889 750 1377751
SGTC_526 4469-0568 170 µM -0.490301083585393 0.308369333893463 no 2317 0.31196043017957 737 2901964
SGTC_2201 6605497 169.863 µM -0.490423272919792 0.308325048524697 no 2318 0.311917205755977 761 670741
SGTC_86 0417-1630 471.922 µM -0.491790303536555 0.307829782681577 no 2319 0.311433795974647 763 3634867
SGTC_1301 naphtanilide LB 4.81 µM -0.494512465755337 0.306844604636682 no 2320 0.310472152411131 767 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1900 st060200 72.8 µM -0.495562023901396 0.306465130713009 no 2321 0.310101725914065 737 688945
SGTC_2895 9054447 58.44 µM -0.496977948889158 0.305953523425519 no 2322 0.309602300756458 749 2697450
SGTC_310 1273-0058 1.06 µM -0.497211510986276 0.305869168226222 no 2323 0.309519952452398 745 2734232
SGTC_214 4373-3496 70 µM -0.49733846612859 0.305823320387171 no 2324 0.309475195174186 772 3779166
SGTC_2188 6126565 140.678 µM -0.497564085966135 0.305741848865714 no 2325 0.309395661219988 750 874518
SGTC_113 0099-0221 2.5 µM -0.497707418390702 0.305690096394985 no 2326 0.309345139296275 758 89219
SGTC_1928 4'-methoxychalcone 40.3 µM -0.498925056582378 0.30525060520517 no 2327 0.308916090680042 773 641818
SGTC_682 0kpi-0099 17 µM -0.498948324342299 0.305242209730388 no 2328 0.308907894556823 771 1714895 YML126C ERG13
SGTC_1314 1222-0010 41.1 µM -0.502643476181538 0.30391022737057 no 2329 0.307607478287458 769 3526027
SGTC_1336 1486-0901 104 µM -0.502677172771653 0.303898092776995 no 2330 0.307595630698131 743 5006114
SGTC_1029 k015-0030 64.7 µM -0.503408467523682 0.30363479699 no 2331 0.307338559776436 739 2208316
SGTC_146 3448-8650 53.125 µM -0.503411013459301 0.30363388052777 no 2332 0.307337664972816 786 2891488 YIL048W NEO1
SGTC_3217 9129673 49.47 µM -0.503415940502794 0.303632106939975 no 2333 0.307335933299781 771 17248312
SGTC_3246 9135460 32.98 µM -0.503923101900629 0.303449568802798 no 2334 0.307157707861283 763 41446951
SGTC_2721 ifenprodil 61.44 µM -0.50402766810491 0.303411939306108 no 2335 0.307120967119241 741 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_640 3381-0960 37.1 µM -0.504245669001855 0.303333495577854 no 2336 0.307044375799407 762 1745025
SGTC_1123 mangostin 811.285 nM -0.505677009022859 0.302818678734286 no 2337 0.306541705348427 736 5281650 An antioxidant.
SGTC_979 1426-2828 121 µM -0.505811878359314 0.302770189817378 no 2338 0.306494359498138 768 747872
SGTC_455 paf C-16 10 µM -0.505870122369818 0.302749250706595 no 2339 0.306473913949852 762 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_402 epigallocatechin gallate 10 µM -0.50689705858325 0.30238016686993 no 2340 0.30611352482064 769 65064 An antioxidant.
SGTC_854 0422-0053 192 µM -0.507043571256688 0.302327526246677 no 2341 0.306062123495717 739 3596728
SGTC_139 0099-0334 718.624 µM -0.508080483270148 0.301955091095544 no 2342 0.305698450832847 760 97690
SGTC_3352 9151559 45.5865 µM -0.508163463927197 0.301925295244519 no 2343 0.305669355579967 736 17159339
SGTC_1696 st025591 34.7925 µM -0.508754052732689 0.301713270785763 no 2344 0.305462314688677 771 2787147
SGTC_5 0352-0601 109.883 µM -0.508858261498462 0.301675866245293 no 2345 0.305425788998116 766 762456
SGTC_1215 3852-0577 11.2 µM -0.509537688406101 0.301432044891487 no 2346 0.305187693981461 741 2884876
SGTC_1263 0774-1208 64.8 µM -0.510187027895506 0.301199103733941 no 2347 0.304960219669454 802 906585
SGTC_1837 st055472 66.5 µM -0.510569649016693 0.301061881917381 no 2348 0.304826216467085 755 676091
SGTC_3036 9090181 49.47 µM -0.511747174438006 0.300639755478583 no 2349 0.304413982785011 759 25236586
SGTC_2923 7992654 58.14 µM -0.511834997290957 0.300608282919943 no 2350 0.3043832472905 736 2985126
SGTC_805 3852-0218 479 µM -0.511955381081867 0.300565144106771 no 2351 0.304341118640963 757 6615355
SGTC_1509 1326-1131 80 µM -0.513791957480756 0.299907364840279 no 2352 0.303698725729854 746 768313
SGTC_1897 st060201 15 µM -0.515595994218754 0.299261874922775 no 2353 0.303068304327827 759 611878
SGTC_1203 3992-3522 103 µM -0.515687892221143 0.299229010411627 no 2354 0.303036206208128 798 5322312
SGTC_747 3448-8087 38.7 µM -0.51614859027359 0.29906428052581 no 2355 0.302875316596295 789 5168703
SGTC_384 k007-0144 5.16 µM -0.516856422897772 0.29881126401991 no 2356 0.302628194707687 753 6824886
SGTC_2870 9038528 12.99 µM -0.517885754895352 0.298443500465598 no 2357 0.302268990756101 780 6463316
SGTC_1621 st003705 32.4 µM -0.518073499278316 0.298376444671512 no 2358 0.302203494604205 749 24207032
SGTC_2782 7736369 71.43 µM -0.518515144465711 0.298218731345714 no 2359 0.302049448216631 763 2950836 YOL077C BRX1
SGTC_1519 esterone 74 µM -0.518676912900538 0.298160972668729 no 2360 0.301993032011429 762 698 A steroid.
SGTC_3351 9150312 21.596 µM -0.5189149417246 0.298075994836209 no 2361 0.30191002885521 768 4904905
SGTC_749 1000-0129 128 µM -0.518965793708099 0.298057841779325 no 2362 0.301892297562245 784 708470
SGTC_1322 1348-1070 12 µM -0.520565874136775 0.29748690521999 no 2363 0.301334613668738 769 6758089
SGTC_1240 0356-0016 42.1 µM -0.522822922434074 0.296682401250558 no 2364 0.300548743212277 746 4305613
SGTC_1472 k841-0093 193 µM -0.523477941096798 0.29644911257544 no 2365 0.300320848896404 780 X1472
SGTC_2890 9046729 58.44 µM -0.523882810911855 0.29630495791261 no 2366 0.300180025518687 763 903329
SGTC_974 1326-0144 138 µM -0.524053013322305 0.296244366621082 no 2367 0.300120833976812 770 5411856
SGTC_1086 cerivastatin 2.18 µM -0.527457269762277 0.29503366211247 no 2368 0.298938041172073 755 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_3301 9125354 19.7965 µM -0.527579991284181 0.294990059493219 no 2369 0.298895441725901 749 41905162
SGTC_833 3852-0053 558 µM -0.52805374548947 0.294821763785725 no 2370 0.298731016687994 786 3123681
SGTC_3022 9087993 49.47 µM -0.528538823866551 0.294649491172858 no 2371 0.298562704005027 770 17173644
SGTC_1624 st003710 6.25 µM -0.529046776003817 0.294469144869604 no 2372 0.298386500823166 796 24207033
SGTC_2723 salbutamol 83.58 µM -0.530015766797756 0.29412525007854 no 2373 0.298050499577863 780 9884233 β2-adrenoceptor agonist
SGTC_1792 st045773 43.6 µM -0.530546992907183 0.293936796754891 no 2374 0.297866368103659 742 2919270
SGTC_2731 amoxapine 43.43 µM -0.530822133270871 0.293839212219254 no 2375 0.297771020443462 799 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2064 5220758 200 µM -0.532069140366353 0.29339712193497 no 2376 0.297339054900431 761 788518
SGTC_2353 9059630 146.67 µM -0.532306781591806 0.293312908086573 no 2377 0.297256768032426 756 4779114
SGTC_2715 st079500 56.4 µM -0.532594482418089 0.293210969415548 no 2378 0.297157161199178 773 28246688
SGTC_594 1487-1584 10.8 µM -0.532739158760106 0.29315971364282 no 2379 0.297107077598697 795 5013332
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.534842440069879 0.292415035192897 no 2380 0.296379406645307 747 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1767 st044992 70.3 µM -0.535452069506335 0.292199357006912 no 2381 0.296168646348218 789 9600693
SGTC_3045 9092950 49.47 µM -0.536759696741697 0.291736986985691 no 2382 0.295716807240445 769 44120432
SGTC_1721 st082152 9.2685 µM -0.53686097440635 0.291701189974215 no 2383 0.29568182485373 762 5296051
SGTC_1972 st070201 17.4 µM -0.536969462935233 0.291662846523966 no 2384 0.29564435386749 764 2829099
SGTC_2078 5212016 200 µM -0.537168182085494 0.291592618668182 no 2385 0.295575723677294 785 1899708
SGTC_1114 scopoletin 1.73284 µM -0.537398652031099 0.291511179875903 no 2386 0.295496137120332 774 5280460 A coumarin with genotoxic properties.
SGTC_2856 9022925 19.48 µM -0.538372917011156 0.291167031146712 no 2387 0.295159810019703 762 4944862
SGTC_635 k038-0028 24.7 µM -0.538628288113489 0.291076855414808 no 2388 0.295071682239778 788 4035102
SGTC_1220 1838-0075 193 µM -0.538891995095314 0.290983749839531 no 2389 0.294980690494693 748 5529645
SGTC_2053 5265679 138 µM -0.539848760836592 0.290646066696943 no 2390 0.294650668331145 778 764595
SGTC_1052 3253-3998 198 µM -0.540988824194386 0.290243929587293 no 2391 0.294257642904091 761 5450317
SGTC_3148 9097893 49.47 µM -0.541515030612164 0.290058407568067 no 2392 0.294076320225413 746 17174100
SGTC_1120 ficusin 1.78878 µM -0.541641980724205 0.290013657712942 no 2393 0.294032582893345 789 6199 A DNA cross-linker.
SGTC_2175 5807670 165.306 µM -0.543736922864774 0.28927565942252 no 2394 0.293311260177924 766 241186
SGTC_394 menadione 8.33 µM -0.544693904042914 0.288938831658899 no 2395 0.29298202907143 788 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_325 2810-4341 181 µM -0.545075546746481 0.288804556728261 no 2396 0.292850780027056 758 774970
SGTC_591 4299-0174 154 µM -0.546401165191696 0.288338387277266 no 2397 0.292395104670119 779 5509088
SGTC_1671 st016596 74.5 µM -0.548992937977733 0.287427985999199 no 2398 0.291505148126063 777 2829167
SGTC_31 0508-1974 57.237 µM -0.549859063261719 0.287124049135684 no 2399 0.291208022049861 757 6810525
SGTC_1527 coumarin 137 µM -0.552224372003253 0.28629480154294 no 2400 0.290397319144553 826 323 A hepatotoxic, DNA x-linker.
SGTC_432 NS 1619 61.3 µM -0.552693594482511 0.286130433285046 no 2401 0.290236620149088 760 4552 A K+/calcium channel activator.
SGTC_1286 0929-0070 131 µM -0.555630456402313 0.285102672652085 no 2402 0.289231753264451 785 1420408
SGTC_2116 5511452 16.8835 µM -0.556920017138001 0.284651945002943 no 2403 0.288791038764313 798 870744
SGTC_2037 5169046 200 µM -0.55834553720151 0.284154093042384 no 2404 0.2883042276295 775 5718022
SGTC_3151 9099821 49.47 µM -0.559146303107846 0.283874614453625 no 2405 0.288030938149591 799 17174189
SGTC_2296 7971656 126.45 µM -0.560187152437445 0.283511540144538 no 2406 0.287675894643395 771 666570
SGTC_697 0508-1955 564 µM -0.560530434105219 0.283391843723525 no 2407 0.28755884340501 794 6243113
SGTC_107 0358-0022 2.6945 µM -0.560955871638748 0.283243534590819 no 2408 0.28741381013711 811 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2817 7995342 71.43 µM -0.563569462463732 0.282333244759545 no 2409 0.286523587158984 803 18879975
SGTC_659 k018-0002 107 µM -0.563606848616275 0.282320233721038 no 2410 0.286510862445513 783 6797879 YHR007C ERG11
SGTC_1723 st034307 2.5525 µM -0.565686595605986 0.281596899968465 no 2411 0.285803424504794 795 867466
SGTC_8 0354-0001 70 µM -0.566293236622863 0.281386079380881 no 2412 0.285597228669403 775 4993152
SGTC_2493 resveratrol 26.09 µM -0.567542669740219 0.280952115092002 no 2413 0.285172772536919 763 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2056 5235370 200 µM -0.567841569642804 0.280848346470066 no 2414 0.28507127515175 777 5511916
SGTC_1893 st059353 36.1 µM -0.568256732155817 0.280704245884926 no 2415 0.284930327073357 829 3112488
SGTC_1126 isoteolin 1.0172 µM -0.568991879332864 0.280449168177782 no 2416 0.284680825462612 762 133323
SGTC_1638 st008370 60.6 µM -0.570256352143107 0.280010690359201 no 2417 0.284251920154018 781 24207134
SGTC_2803 7707263 71.43 µM -0.570319112485683 0.279988935784904 no 2418 0.284230640087204 777 2199229
SGTC_649 1123-0311 367 µM -0.570965866050505 0.279764799786727 no 2419 0.28401139058458 801 693629 YIL048W NEO1
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.571571419208385 0.27955502095745 no 2420 0.283806181399001 814 368090
SGTC_1004 4084-0029 199 µM -0.571617240059586 0.279539150571814 no 2421 0.283790656568936 770 716894 YLR208W SEC13
SGTC_324 1315-0088 19.6 µM -0.572836038232726 0.279117171590351 no 2422 0.283377857767732 794 6787421
SGTC_2878 9043973 25.97 µM -0.573879654815832 0.278756091245567 no 2423 0.283024620750099 787 6465167
SGTC_509 pifithrin 175 µM -0.579007964146914 0.276985061460414 no 2424 0.281291899686231 803 4817 A p53 inhibitor.
SGTC_3321 9137793 26.8275 µM -0.58104552599847 0.276282934372241 no 2425 0.280604885431842 782 4904192
SGTC_1247 0448-0043 5.84 µM -0.581644999027816 0.276076527268752 no 2426 0.280402912985342 803 3089013 YGL099W LSG1
SGTC_206 4546-0025 72.014 µM -0.581798357475187 0.27602373593479 no 2427 0.280351255279118 822 6620745 YIL048W NEO1
SGTC_2004 4023728 41.89 µM -0.582136638998008 0.275907305149154 no 2428 0.280237323842339 810 360084 YDR527W RBA50
SGTC_2699 st077704 54.6 µM -0.58329924247541 0.275507340705192 no 2429 0.279845936201879 791 645852
SGTC_803 4488-1585 147 µM -0.584125290702959 0.27522333302138 no 2430 0.279568010282355 782 747204
SGTC_376 3970-0862 59.1 µM -0.585365096182064 0.274797340117843 no 2431 0.279151126397839 811 3135186
SGTC_2178 5812956 200 µM -0.585733845085249 0.274670702005052 no 2432 0.27902719312419 796 5403383
SGTC_1189 1431-2119 7.28 µM -0.586020257957964 0.274572360122893 no 2433 0.278930950736077 808 3107275
SGTC_586 0957-0265 8.15 µM -0.58619812270655 0.274511297749521 no 2434 0.278871191551456 784 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_700 3453-2283 142 µM -0.587007245740487 0.274233604019266 no 2435 0.278599420203206 788 565664
SGTC_1570 verbenone 133 µM -0.58710552261244 0.274199884518977 no 2436 0.278566419377364 797 29025 A natural terpanoid with antifungal properties.
SGTC_2601 securinine 100 µM -0.589073262403202 0.273525170163889 no 2437 0.277906064328502 815 442872 A GABA receptor antagonist.
SGTC_1788 fluconazole 20 µM -0.590291513147199 0.273107858867471 no 2438 0.277497614103087 817 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_356 1634-0012 32.5 µM -0.590912130635092 0.272895387984752 no 2439 0.277289648825526 810 735457
SGTC_2569 tetrandrine 100 µM -0.591230800506525 0.272786321939617 no 2440 0.277182894047892 770 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1102 cgs 12066b 26.1 µM -0.591760735018836 0.27260499761614 no 2441 0.277005409903992 774 6438352 A 5-HT1B full agonist.
SGTC_3316 9136639 10.545 µM -0.592016147540337 0.272517626108778 no 2442 0.276919887748496 795 4903665
SGTC_1641 st009299 47.1 µM -0.592212573286953 0.272450442255001 no 2443 0.27685412548058 784 4046054
SGTC_548 1436-0017 110 µM -0.592507734972346 0.272349503038334 no 2444 0.276755321343158 799 9677137
SGTC_2525 harmine 47.85 µM -0.592957160016775 0.272195844618333 no 2445 0.276604911377407 776 5280953 A monoamine oxidase inhibitor
SGTC_2122 5258151 111.688 µM -0.594207675986991 0.27176852008837 no 2446 0.276186609694178 793 2173356
SGTC_1760 st045453 10.4495 µM -0.596726866765422 0.270908680852548 no 2447 0.275344876014112 811 3323419 YIL048W NEO1
SGTC_1553 gossypol 38.6 µM -0.596849131024209 0.270866984714247 no 2448 0.27530405617294 799 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_317 4495-0002 170 µM -0.597251223373081 0.270729880573633 no 2449 0.275169832341376 795 15991618
SGTC_404 fumagillin 50 µM -0.597526890494476 0.270635904520277 no 2450 0.275077829572047 803 12015870 A methionine aminopeptidase binder.
SGTC_587 k089-0003 57 µM -0.597821598018918 0.270535455537389 no 2451 0.274979488905956 801 9659696
SGTC_3096 9117468 49.47 µM -0.598275574012863 0.270380757472615 no 2452 0.274828035999897 803 41316311
SGTC_1429 4049-0205 9.46 µM -0.599245427832773 0.270050415706125 no 2453 0.274504616664916 791 22774478
SGTC_889 0919-1524 82.7 µM -0.600003562351832 0.269792328318235 no 2454 0.274251930688068 794 3905452
SGTC_1830 st055982 50.3 µM -0.600060996075757 0.269772781518737 no 2455 0.27423279272889 831 455313 An antimicrobial agent.
SGTC_1786 berberine 21.6 µM -0.600076881813373 0.269767375145691 no 2456 0.274227499429248 802 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_32 0928-0142 34.1 µM -0.601440504757932 0.269303497387926 no 2457 0.273773313668008 806 2244242
SGTC_2067 5224629 34.075 µM -0.601512885897216 0.269278885929737 no 2458 0.273749215878431 800 2835000
SGTC_1938 st074717 56.4 µM -0.602320027068493 0.26900451351839 no 2459 0.273480566171685 777 17250979
SGTC_1362 1611-0397 101 µM -0.602729071201321 0.268865520280504 no 2460 0.273344469344004 806 27816
SGTC_71 0417-1750 47.813 µM -0.603041574669965 0.268759355876423 no 2461 0.273240516052649 759 6811472
SGTC_842 0271-0008 11.1 µM -0.605385756885429 0.26796365688194 no 2462 0.272461356276422 791 1221709
SGTC_2277 7947813 106.88 µM -0.606012237385173 0.267751208123688 no 2463 0.272253313551472 806 1246798
SGTC_3274 9138298 49.47 µM -0.606392251597864 0.267622381078268 no 2464 0.272127156252079 803 17015756
SGTC_1963 st076565 50.3 µM -0.606569455624948 0.267562318558131 no 2465 0.272068337911717 819 4914280
SGTC_963 1269-2853 151 µM -0.607340815188613 0.267300948853303 no 2466 0.271812378519454 772 3668223
SGTC_2148 5546263 113.568 µM -0.607964141308959 0.267089833383013 no 2467 0.271605628477071 785 792097
SGTC_2421 5690543 90.72 µM -0.608201269093204 0.267009542248168 no 2468 0.271526996508073 817 3397993
SGTC_511 blebbistatin 171 µM -0.610897680390668 0.266097399372199 no 2469 0.270633660289896 797 3476986 A myosin inhibitor.
SGTC_2924 9010168 62.78 µM -0.611062209278411 0.266041793610467 no 2470 0.270579198498322 794 2993929
SGTC_399 oxolinic acid 75 µM -0.612739879504561 0.265475128260061 no 2471 0.27002417453545 780 4628 A DNA gyrase inhibitor.
SGTC_1522 st012842 45.6 µM -0.613664835270105 0.265162968775749 no 2472 0.269718415051009 803 3491067 YOR116C RPO31
SGTC_264 promethazine 12.5 mM -0.617131835702323 0.263994566350053 no 2473 0.268573885830484 829 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2942 9052777 62.25 µM -0.617388371508262 0.263908216429678 no 2474 0.268489295099606 836 6469503
SGTC_1116 jasmonic acid 1.58368 µM -0.617824398332424 0.263761482894273 no 2475 0.268345549308022 825 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_3146 9095609 49.47 µM -0.617923977304598 0.26372797800703 no 2476 0.268312726349348 810 17173999
SGTC_2492 derrusnin 100 µM -0.617991015105569 0.263705423323395 no 2477 0.268290630663322 818 1715307 Part of coumarin class of compounds.
SGTC_797 k781-0471 270 µM -0.618645873465708 0.263485149790629 no 2478 0.268074837240407 789 23738129
SGTC_3312 9133330 71.43 µM -0.618912079159192 0.263395633513414 no 2479 0.267987140296825 828 17617324
SGTC_1876 myriocin 605 nM -0.61976631217853 0.263108487747332 no 2480 0.267705825323995 828 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1561 5-methoxyflavone 52.9 µM -0.62003705071194 0.263017513860061 no 2481 0.267616697108965 797 94525
SGTC_861 0443-0273 110 µM -0.620327658714792 0.262919881303416 no 2482 0.267521044432447 809 6149169
SGTC_2824 7998404 51.95 µM -0.620580611923983 0.262834914322859 no 2483 0.267437799743878 825 837851
SGTC_3188 9110789 49.47 µM -0.62200251213981 0.262357559508058 no 2484 0.266970108076346 813 849217
SGTC_2859 9028643 45.46 µM -0.622626162648335 0.262148330142432 no 2485 0.266765107248259 789 17151580
SGTC_3037 9091026 49.47 µM -0.622748024978152 0.262107456370486 no 2486 0.266725059044544 811 25236398 YIL048W NEO1
SGTC_954 1189-0853 2.85 µM -0.623031028825137 0.262012546819052 no 2487 0.266632065853627 819 2828194
SGTC_2050 5263056 171 µM -0.623854000339314 0.261736651217522 no 2488 0.266361736037983 796 763468 YGL055W OLE1
SGTC_3259 9138485 49.47 µM -0.624068469383668 0.261664776419956 no 2489 0.266291309998985 789 17646153
SGTC_770 0389-1121 67.2 µM -0.62440930660563 0.261550572822768 no 2490 0.266179407339958 798 6753108
SGTC_1910 st062352 60.4 µM -0.624723202660993 0.261445418982192 no 2491 0.266076370987927 796 2245730
SGTC_967 1306-0166 352 µM -0.625001899967109 0.2613520747696 no 2492 0.265984905554024 814 4437607
SGTC_2996 9066192 71.4286 µM -0.628036638538638 0.260336757631391 no 2493 0.264989969370226 800 6472854
SGTC_3239 9133757 49.47 µM -0.629281740216471 0.259920778922543 no 2494 0.264582311726336 832 17036923
SGTC_1879 gemcitabine 100 µM -0.630411829811614 0.259543521867099 no 2495 0.264212586482819 818 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1374 2889-5571 141 µM -0.630560895218023 0.259493780578055 no 2496 0.264163837217917 808 2853281
SGTC_1317 1273-0028 910 nM -0.630631010938831 0.259470385528732 no 2497 0.26414090866766 808 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_745 0469-0705 296 µM -0.631971654554793 0.259023271470084 no 2498 0.263702699729919 823 3486736
SGTC_1074 carmofur 3.8 µM -0.632454283540946 0.258862408909365 no 2499 0.263545036223508 823 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_933 2914-0560 114 µM -0.632464138567073 0.258859124720381 no 2500 0.263541817320143 786 463887
SGTC_1816 st051957 91.6 µM -0.633308808326863 0.258577718522548 no 2501 0.263266001165062 818 674121
SGTC_1226 3909-7979 35.4 µM -0.633893161175251 0.258383131026148 no 2502 0.263075274496748 813 6615510
SGTC_208 k072-0098 12.366 µM -0.635248224026253 0.257932191872589 no 2503 0.262633268010878 822 5948901
SGTC_2135 5326629 150.42 µM -0.635432399848315 0.257870933194108 no 2504 0.262573221246436 813 5020077
SGTC_3203 9113543 49.47 µM -0.636754050168058 0.25743156094659 no 2505 0.262142530371641 802 17018012
SGTC_2543 pimpinellin 60.67 µM -0.636787803042951 0.257420345164557 no 2506 0.262131535945213 804 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_204 PMA1.184 62.41 µM -0.636817437434101 0.257410498127587 no 2507 0.262121883239815 817 2252213 YGL008C PMA1
SGTC_2496 diffractaic acid 79.83 µM -0.639434055503023 0.256541809735829 no 2508 0.261270300203466 818 94870 An apoptosis inducer which activates caspases.
SGTC_1331 1472-0049 76.2 µM -0.640519846768678 0.256181787807205 no 2509 0.260917345240164 826 24051409
SGTC_412 gemfibrozil 100 µM -0.641221764883245 0.255949189142841 no 2510 0.260689305363542 798 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1245 0418-0076 17.2 µM -0.641898461310689 0.255725052703394 no 2511 0.260469556683469 828 6790114
SGTC_148 3253-0744 288.01 µM -0.642913470206598 0.255389052120933 no 2512 0.2601401242138 807 6893655
SGTC_286 k060-0067 22.9 µM -0.642993079189682 0.255362708748714 no 2513 0.26011429531563 799 5985051
SGTC_994 3910-0338 138 µM -0.643261007019822 0.2552740593072 no 2514 0.260027376639708 819 3479481
SGTC_2453 5731132 22.18 µM -0.646109827013223 0.25433246444756 no 2515 0.259104115817201 828 1362040
SGTC_458 nppb 133 µM -0.647771129312219 0.253784210729361 no 2516 0.258566495543481 813 4549 A chloride channel blocker.
SGTC_2879 9041815 71.43 µM -0.647947575894079 0.253726017284656 no 2517 0.258509428956774 800 4942971
SGTC_1822 st052468 42 µM -0.648057934348796 0.253689623776467 no 2518 0.258473739995669 810 2873678
SGTC_639 0833-0042 114 µM -0.650049871388764 0.253033203446794 no 2519 0.257830003986827 836 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_35 0133-0054 64.071 µM -0.651132834897769 0.252676700418324 no 2520 0.257480371195428 823 99677
SGTC_2125 5246583 200 µM -0.654811926177557 0.251467551297267 no 2521 0.256294425554876 823 835267
SGTC_2694 st077685 81.9 µM -0.655023547465619 0.251398094172722 no 2522 0.256226296679007 787 2838096
SGTC_1699 st031318 29.054 µM -0.65538261529601 0.251280266193573 no 2523 0.256110720804313 812 5340658
SGTC_2884 9058502 51.95 µM -0.656463726030648 0.250925676480372 no 2524 0.255762899767399 814 6471554
SGTC_3198 9112019 49.47 µM -0.657885015587396 0.250459915949415 no 2525 0.255306009969576 856 45595555
SGTC_135 0933-0004 26.348 µM -0.658822880954383 0.250152825962022 no 2526 0.255004756231844 813 21230617 YGL099W LSG1
SGTC_1015 4130-4525 82 µM -0.659268955297701 0.250006835704092 no 2527 0.254861537031208 823 1363237
SGTC_2661 dactinomycin 12.96 µM -0.659290825375896 0.249999679274407 no 2528 0.254854516380621 816 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_3169 9102970 49.47 µM -0.659495123807789 0.249932833033008 no 2529 0.254788938153014 824 17027839
SGTC_1449 4112-4002 201 µM -0.66139602123904 0.249311316334455 no 2530 0.254179188425232 820 2059539
SGTC_102 gallobenzophenone 83.616 µM -0.662213391510636 0.249044322104249 no 2531 0.253917236520428 813 70837
SGTC_1728 st035614 33.7865 µM -0.662214147221066 0.249044075321634 no 2532 0.253916994394924 816 15945546
SGTC_294 k038-0071 157 µM -0.662830888804048 0.248842717360169 no 2533 0.253719434160473 824 24152826
SGTC_914 3820-6779 408 µM -0.663001180804729 0.248787134549192 no 2534 0.253664898912404 806 2893481
SGTC_2394 5221648 200 µM -0.663289179059572 0.248693147805864 no 2535 0.253572682776914 825 788586
SGTC_2726 cimetidine 79.27 µM -0.663710228771366 0.248555774444906 no 2536 0.253437895684391 832 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2747 doxorubicin 7.63 µM -0.663775519864582 0.248534475933151 no 2537 0.253416997969991 770 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1658 st012944 20 µM -0.665176054230813 0.248077843905594 no 2538 0.252968947215036 815 24207260
SGTC_561 1550-0330 72.9 µM -0.670922611972769 0.246208924050772 no 2539 0.251134915308067 820 6812934
SGTC_1975 st070967 30.8 µM -0.671607373548298 0.245986727500066 no 2540 0.250916841445708 828 261391
SGTC_1758 st042942 75.2445 µM -0.671880633692986 0.245898088051055 no 2541 0.25082984513481 823 669317
SGTC_1471 k673-0312 37 µM -0.672289430654294 0.245765515515293 no 2542 0.250699728541073 814 24099884
SGTC_491 tetrandrine 80.3 µM -0.6723290104888 0.245752681843617 no 2543 0.250687132514894 832 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1623 st003709 20.3 µM -0.673042732227161 0.245521320941838 no 2544 0.250460052719196 816 16192618
SGTC_253 dyclonine 31.25 µM -0.673999846060013 0.245211245531065 no 2545 0.250155705775003 819 3180 An oral anasthetic.
SGTC_40 0327-0103 19.753 µM -0.674955974818562 0.244901699609684 no 2546 0.24985186803502 818 409036
SGTC_1610 st001799 48.1 µM -0.675408007694301 0.244755427569085 no 2547 0.249708289665867 830 621897
SGTC_643 k048-0106 28.4 µM -0.676072301532351 0.244540555976698 no 2548 0.249497370774747 834 6763920
SGTC_1047 2043-3044 82 µM -0.677081355825414 0.244214363126027 no 2549 0.24917716873559 862 669592
SGTC_2407 paclitaxel 400 µM -0.678323466329583 0.243813153479373 no 2550 0.248783311544535 857 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_849 0386-0493 241 µM -0.679422399900616 0.243458487716702 no 2551 0.248435130454648 837 726119
SGTC_1748 st037455 53.6035 µM -0.67953030830672 0.243423676790614 no 2552 0.248400955256375 834 580690
SGTC_1708 st033234 31.827 µM -0.67955038903481 0.24341719910515 no 2553 0.248394595853549 806 674664
SGTC_419 nsc-638432 893 µM -0.680591588663008 0.243081454284432 no 2554 0.248064975356546 814 368090
SGTC_2711 st079103 59.1 µM -0.68083943392302 0.243001571117948 no 2555 0.24798654749339 830 54693780
SGTC_786 4544-0069 423 µM -0.681518143858814 0.24278288838325 no 2556 0.24777184506223 829 748821 YLR208W SEC13
SGTC_3026 9090633 49.47 µM -0.681796623187113 0.242693192188647 no 2557 0.247683779910397 830 25236842
SGTC_3210 9128157 49.47 µM -0.683140944104557 0.242260448503133 no 2558 0.247258892644645 833 17590849
SGTC_1960 st011366 51.8 µM -0.683267592544798 0.242219701298164 no 2559 0.247218884122255 843 3972846
SGTC_2662 daunorubicin 22.37 µM -0.683521601186301 0.242137989088338 no 2560 0.247138652665571 800 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2381 9035592 200 µM -0.684283077896753 0.241893118719187 no 2561 0.246898215248162 827 4749657
SGTC_12 0849-0099 9.267 µM -0.684532685716436 0.241812880824481 no 2562 0.246819428457159 832 6071388
SGTC_2999 9069765 71.4286 µM -0.685325462955733 0.241558133750052 no 2563 0.246569283692778 807 2097066
SGTC_3278 9139605 49.47 µM -0.686749911912797 0.24110077484219 no 2564 0.246120169182672 840 7958859
SGTC_2472 5377652 49.4 µM -0.686822885716524 0.241077357259296 no 2565 0.24609717309244 846 1610903
SGTC_255 tunicamycin 200.472 nM -0.686997001208829 0.241021487903503 no 2566 0.246042309078005 822 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_949 1165-0505 146 µM -0.687047717387057 0.241005215660282 no 2567 0.246026329579414 835 6244267
SGTC_2620 irigenin 100 µM -0.687262959201963 0.240936162153386 no 2568 0.245958518041723 835 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_664 1222-0054 14.9 µM -0.68773281853578 0.240785460088444 no 2569 0.245810524572118 825 6813991
SGTC_1731 st035964 63 µM -0.687903665569672 0.240730675554018 no 2570 0.245756724052975 852 6739575
SGTC_2606 farnesol 9.78 µM -0.688603705604967 0.240506268607405 no 2571 0.245536344254443 848 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_757 1066-0008 322 µM -0.689197929655505 0.240315871774373 no 2572 0.245349359753923 819 6842497
SGTC_631 k072-0230 41.5 µM -0.689214653880443 0.2403105143115 no 2573 0.245344098249099 835 5773147
SGTC_2528 xanthyletin 44.79 µM -0.690128179581413 0.240017973018332 no 2574 0.245056791738496 851 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2072 5231554 129 µM -0.690917301998894 0.239765426187102 no 2575 0.244808756186802 829 789545
SGTC_2249 haloperidol 116.36 µM -0.691036052441128 0.239727434438304 no 2576 0.244771442460765 838 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_234 nsc-17383 10.7 µM -0.691716870440116 0.239509684212075 no 2577 0.244557575152921 814 408974
SGTC_2921 7974240 10.71 µM -0.692846748950351 0.239148546637606 no 2578 0.244202865427567 829 2979074 YDR527W RBA50
SGTC_276 colchicine 750 µM -0.694555612538621 0.238602916752135 no 2579 0.243666918789698 843 2833 A microtubule depolymerizer.
SGTC_517 1365-0151 113 µM -0.694640780142269 0.238575741083486 no 2580 0.243640224510983 834 768657
SGTC_2778 tioconazole 65.09 nM -0.69486104182704 0.238505466834206 no 2581 0.24357119470602 838 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2376 9072922 81.32 µM -0.695219633483525 0.238391082804861 no 2582 0.243458835018348 837 17087968
SGTC_1921 5740136 50 µM -0.695923610168789 0.238166614814544 no 2583 0.243238335225884 836 1774243
SGTC_566 0958-0068 16.5 µM -0.695937775194217 0.23816209938398 no 2584 0.243233899560518 833 6815365
SGTC_1366 1683-0113 21.9 µM -0.697290516910672 0.237731097783127 no 2585 0.242810500768211 838 708623
SGTC_618 k072-0232 33.2 µM -0.698236362043129 0.237429993233396 no 2586 0.242514694900503 835 5872756 YGL099W LSG1
SGTC_1049 3226-0134 66 µM -0.698589202284379 0.237317722144025 no 2587 0.242404396807479 827 5702385
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.699320991035705 0.237084965475129 no 2588 0.242175725822635 845 390807
SGTC_2330 7979373 200 µM -0.699368103922144 0.237069984796028 no 2589 0.242161007890408 830 1863007
SGTC_2326 6164455 177.58 µM -0.699587878320623 0.237000109096063 no 2590 0.242092357398716 836 2888790
SGTC_1367 1812-0510 76.9 µM -0.701035556476769 0.236540113150605 no 2591 0.241640412868328 821 1142582 YDR527W RBA50
SGTC_1396 3511-0007 98.6 µM -0.701875656460945 0.236273399019824 no 2592 0.241378355778149 821 X1396
SGTC_1597 7-benzyloxygramine 47.5 µM -0.701895621295969 0.236267062618495 no 2593 0.241372129914205 841 260807
SGTC_405 ebelactone b 50 µM -0.702632761367062 0.236033176028068 no 2594 0.241142320142308 836 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1625 st003711 30.1 µM -0.70348783942806 0.235762028886648 no 2595 0.240875891267271 847 24207034 YER133W GLC7
SGTC_2505 galangin 7.89 µM -0.704768613731671 0.235356214020293 no 2596 0.240477121888659 853 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1795 st049545 62.3 µM -0.70740748612849 0.234521301088491 no 2597 0.239656643035851 810 5291882
SGTC_2187 6125751 200 µM -0.709086086751291 0.233991062327774 no 2598 0.239135528208371 840 874498
SGTC_1895 st058434 18.3 µM -0.709216897392208 0.233949769586422 no 2599 0.23909494459655 862 5393175
SGTC_754 3474-0146 171 µM -0.709297059258624 0.233924467040609 no 2600 0.239070076476678 830 24762078
SGTC_2954 9074818 52.69 µM -0.710106724017987 0.233668986899946 no 2601 0.238818978464317 845 16648742
SGTC_2477 5967686 25.23 µM -0.711527936095201 0.233220914543554 no 2602 0.238378572851839 841 776118
SGTC_1363 1636-0063 10.4 µM -0.711770544307098 0.233144473968669 no 2603 0.238303437814645 833 6072185
SGTC_740 k014-0057 261 µM -0.712557457497305 0.232896630473232 no 2604 0.238059822449384 840 4012779
SGTC_2688 kanamycin b 96.69 µM -0.714089000546832 0.232414680793558 no 2605 0.237586073547 825 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2679 rapamycin 1 nM -0.714750372113593 0.232206730405038 no 2606 0.23738165296992 823 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_181 1447-1644 8.07 µM -0.714889111975427 0.232163120552942 no 2607 0.237338782702578 858 534600
SGTC_585 0kpi-0023 191 µM -0.715071654422205 0.232105749257709 no 2608 0.237282384024325 817 64601
SGTC_364 0083-0097 67.7 µM -0.715378126403891 0.232009445878308 no 2609 0.237187712384602 851 5207356
SGTC_263 alizarin 107.927 µM -0.715537094605156 0.231959501707371 no 2610 0.237138614013445 868 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2594 a-mangostin 100 µM -0.71710663479032 0.231466709591248 no 2611 0.23665415109647 855 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2238 6671620 73.2395 µM -0.717752929863783 0.231263960643327 no 2612 0.236454820470794 832 729941
SGTC_773 4358-1457 44.6 µM -0.718449531637393 0.231045540983411 no 2613 0.236240077748256 864 1186886
SGTC_826 1683-5028 118 µM -0.718648204531335 0.230983268156608 no 2614 0.236178852175891 846 722377
SGTC_3165 9101544 49.47 µM -0.719396813339319 0.230748705405016 no 2615 0.235948229870063 835 5002184
SGTC_1925 st057770 10.1 µM -0.719634560850069 0.230674239458052 no 2616 0.23587501348138 837 5989122
SGTC_345 1362-0200 395 µM -0.719891860113956 0.230593664749855 no 2617 0.235795790075476 843 1419823
SGTC_183 3914-0051 30.55 µM -0.720315117791257 0.230461153454732 no 2618 0.23566549937577 826 1596232
SGTC_2541 muurolladie-3-one 83.07 µM -0.720454158678513 0.230417632552491 no 2619 0.235622707319007 853 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_900 1112-0045 141 µM -0.721163013244703 0.23019582687886 no 2620 0.235404612628596 828 56211 YIL048W NEO1
SGTC_1323 1348-1351 11.2 µM -0.721655532565734 0.230041784400921 no 2621 0.235253143855913 827 6989654
SGTC_2795 7780010 54.55 µM -0.722855256130669 0.229666795153503 no 2622 0.234884407665414 846 953673
SGTC_1341 1486-1360 280 µM -0.723735583238273 0.229391855365198 no 2623 0.234614041591252 862 3976547
SGTC_1451 4152-0210 104 µM -0.724341629421087 0.229202685027238 no 2624 0.234428012754088 850 659563
SGTC_600 1495-0418 41.6 µM -0.725122207814412 0.228959165420667 no 2625 0.234188530707353 857 5377768
SGTC_817 1391-0715 46 µM -0.725345527123041 0.228889522480538 no 2626 0.234120041100491 859 1353946
SGTC_1457 k015-0032 57.3 µM -0.727660078996939 0.228168421581742 no 2627 0.233410846775089 853 4302660
SGTC_701 4424-0219 185 µM -0.728541702820013 0.227894087108331 no 2628 0.233141025051346 838 2911779
SGTC_2712 st079126 47.7 µM -0.729686280010836 0.227538206580448 no 2629 0.232790984707097 844 3152970
SGTC_80 0159-0065 512.242 µM -0.73148074119775 0.22698088971367 no 2630 0.232242781873539 834 1548079
SGTC_2875 9039966 71.43 µM -0.733048159535631 0.226494717446458 no 2631 0.231764528347643 862 6463691
SGTC_1061 3448-9325 110 µM -0.735598099061568 0.225705050462907 no 2632 0.230987659894234 848 723482
SGTC_1673 st016611 27.3 µM -0.736183927426208 0.225523851011643 no 2633 0.230809386102898 858 5226799
SGTC_2447 5741742 33.78 µM -0.738144523217529 0.224918028803068 no 2634 0.230213315257978 849 1776504
SGTC_804 1595-0054 20.9 µM -0.741413523878303 0.223909965001052 no 2635 0.229221373521442 861 761523 Stimulates phospholipase C.
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.741683803698176 0.223826733711719 no 2636 0.229139467537903 868 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2108 5365811 200 µM -0.7418002106957 0.223790892190165 no 2637 0.229104196452652 840 780283
SGTC_468 gf-109203x 121 µM -0.741800920426634 0.223790673675193 no 2638 0.229103981414952 834 2396 A protein kinase C inhibitor.
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.742401464691519 0.223605819033007 no 2639 0.228922066200799 862 94937 An inhibitor of serotonin biosynthesis.
SGTC_3176 9106582 49.47 µM -0.743029038043189 0.223412737336336 no 2640 0.228732050055008 811 17018027
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.743584813708369 0.223241824429826 no 2641 0.228563846715632 875 5393153
SGTC_3332 9141069 11.198 µM -0.744032240682557 0.223104285154547 no 2642 0.228428485180252 855 17332883
SGTC_3023 9089636 49.47 µM -0.747105789556711 0.222160779816726 no 2643 0.227499852867888 876 17249241
SGTC_1313 1220-0047 237 µM -0.749845985218849 0.22132152937851 no 2644 0.226673734671177 848 3528706
SGTC_439 amiodarone 34.4 µM -0.750163360851938 0.221224442803255 no 2645 0.226578161323141 857 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_619 1652-1634 108 µM -0.751465322690001 0.220826422115588 no 2646 0.226186331406242 860 5400454
SGTC_1312 1218-2183 165 µM -0.752023583065844 0.220655882903723 no 2647 0.226018438371804 849 6744073
SGTC_69 0096-0274 206.684 µM -0.752586863351106 0.220483886682972 no 2648 0.225849107057868 876 6741392
SGTC_104 0074-0074 590.992 µM -0.752758175106628 0.220431592309015 no 2649 0.225797622159248 843 3943124
SGTC_2194 5927483 104.545 µM -0.753029326550058 0.220348835551333 no 2650 0.225716145673345 820 760979
SGTC_1124 fisetin 1.16336 µM -0.753392175268254 0.220238120202196 no 2651 0.225607141710287 859 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_3256 9138902 49.47 µM -0.753870775603629 0.220092134576247 no 2652 0.225463410186894 880 17228773
SGTC_433 pimozide 108 µM -0.75473803581337 0.219827738992387 no 2653 0.225203089848501 853 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2311 7694451 200 µM -0.755080297323975 0.219723446299351 no 2654 0.225100402118505 858 2163142
SGTC_2324 6149169 200 µM -0.756929127776704 0.219160568772695 no 2655 0.224546161803927 849 2888231
SGTC_2536 dehydroabietamide 32.04 µM -0.75708785298435 0.219112283460645 no 2656 0.224498615455467 863 3983547
SGTC_3138 9097216 49.47 µM -0.760105770807081 0.218195376366454 no 2657 0.223595681732628 860 25237486
SGTC_1344 1488-0097 29.1 µM -0.76018200125922 0.218172244613916 no 2658 0.223572901045524 868 747966
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.760643416186656 0.218032260712575 no 2659 0.223435040116413 879 6708760
SGTC_2850 9015429 58.44 µM -0.760724658058672 0.218007618943551 no 2660 0.22341077178797 878 6457570
SGTC_1835 st008666 49.2 µM -0.760989341158801 0.217927348083093 no 2661 0.223331716849024 856 690455
SGTC_1872 amphotericin b 148 nM -0.762521317364258 0.21746307817082 no 2662 0.222874462566335 849 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1992 st073643 23.3 µM -0.76463307400968 0.216824041020117 no 2663 0.222245034399245 866 3161292
SGTC_3287 9117173 37.0625 µM -0.765963050687375 0.216422135579407 no 2664 0.221849143938133 822 2789709
SGTC_1044 1222-0021 1.78 µM -0.766530563594494 0.21625077026645 no 2665 0.221680336631081 841 4306703
SGTC_1678 st019265 80.2 µM -0.769154512205836 0.215459468848777 no 2666 0.220900795203584 853 5367020
SGTC_1321 1326-2144 215 µM -0.76947182466116 0.215363891235151 no 2667 0.220806632230107 875 3513030
SGTC_2450 5739737 12.93 µM -0.770306001060125 0.215112746518472 no 2668 0.220559198726044 857 2262825
SGTC_895 0964-0006 13.7 µM -0.770358742345334 0.215096873465402 no 2669 0.220543559941231 875 6738897
SGTC_1258 0671-0043 57.1 µM -0.770760867768183 0.214975871884134 no 2670 0.220424343068476 881 4298767
SGTC_3134 9127454 49.47 µM -0.775572681114583 0.213531042295996 no 2671 0.219000667926423 876 24262820
SGTC_2990 9074105 71.4286 µM -0.778176225235126 0.212751648481062 no 2672 0.21823256532801 876 6502001
SGTC_1659 st012954 42.1 µM -0.779420621106743 0.212379715024611 no 2673 0.217865990233424 865 24207262
SGTC_2233 sulbentine 40.3845 µM -0.781332248913816 0.211809095523159 no 2674 0.217303553794521 854 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_3342 9147791 14.508 µM -0.781760620093401 0.211681350181387 no 2675 0.217177634131196 858 1838168
SGTC_1002 4049-0206 172 µM -0.783444481880688 0.211179639929296 no 2676 0.21668307181487 860 4662749
SGTC_602 3130-1533 38.1 µM -0.784115221113646 0.210979985948449 no 2677 0.21648625243225 868 720941
SGTC_2531 methyl deoxycholate 70.07 µM -0.784365560478068 0.210905497651126 no 2678 0.216412820240032 878 16667744 Haematoxylin.
SGTC_934 2950-0684 338 µM -0.785102037889539 0.210686448762361 no 2679 0.216196872495348 867 1121253
SGTC_977 1348-1378 135 µM -0.785578020166281 0.210544949412906 no 2680 0.216057372774192 854 X977
SGTC_829 1635-0120 117 µM -0.785653554013963 0.210522499944134 no 2681 0.216035240293287 859 285054
SGTC_2397 5161689 200 µM -0.788053765821258 0.209809863150491 no 2682 0.215332628658163 873 2259942
SGTC_1209 2323-2347 50.3 µM -0.788116683852371 0.20979120151686 no 2683 0.215314228576705 846 5412760
SGTC_442 cape 100 µM -0.791450205573008 0.208803867445729 no 2684 0.214340661285175 848 5281787
SGTC_971 1315-0384 26.7 µM -0.791532450500442 0.208779542517236 no 2685 0.214316673759763 886 6769120
SGTC_3044 9093193 49.47 µM -0.792100260560152 0.208611651415126 no 2686 0.214151109093332 855 25236277
SGTC_1927 st060202 13.8 µM -0.794042418276025 0.208037992732313 no 2687 0.213585368763086 857 688887
SGTC_1346 1488-2224 62.4 µM -0.794761158361285 0.207825933451281 no 2688 0.213376224523432 856 3722427
SGTC_3330 9141424 71.43 µM -0.794832454830272 0.207804904884295 no 2689 0.213355484666851 862 27261020
SGTC_532 1548-0774 215 µM -0.794904720574335 0.207783591716542 no 2690 0.213334464051386 890 5932993
SGTC_2627 acetyl isogambogic acid 100 µM -0.795328246044202 0.207658708294296 no 2691 0.213211293498139 882 6857789 A caspase activator and apoptosis inducer.
SGTC_611 3453-1652 23.7 µM -0.796080652836559 0.207436958228627 no 2692 0.212992579310609 877 1560575
SGTC_779 1360-0071 233 µM -0.796847357968079 0.207211138196801 no 2693 0.212769843517357 842 7566
SGTC_513 4245-1575 41.7 µM -0.798135352766179 0.206832108556383 no 2694 0.212395973915454 854 719745
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.798714672094125 0.206661761023509 no 2695 0.212227938619324 900 4620898
SGTC_2435 5706476 10.6 µM -0.800305431143642 0.206194429429566 no 2696 0.211766928571548 842 5725375
SGTC_1657 st012939 43.4 µM -0.80178715844916 0.205759693131878 no 2697 0.211338044078644 851 24207257
SGTC_3122 9126309 49.47 µM -0.803311277466158 0.205313087147934 no 2698 0.210897420636913 897 17591206
SGTC_2962 9082311 13.18 µM -0.806931904552317 0.204254461905417 no 2699 0.209852858149358 888 16459453
SGTC_76 0433-0009 400.328 µM -0.809191599919454 0.20359540623155 no 2700 0.209202472960819 903 2841569
SGTC_1845 st056753 3.01 µM -0.809335166042794 0.203553577075326 no 2701 0.209161191910118 859 5375839
SGTC_612 0302-0167 22.4 µM -0.809707234730698 0.203445195698122 no 2702 0.209054229479188 892 235821
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.810813348711115 0.203123194694504 no 2703 0.208736433750957 856 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_116 0155-0182 31.788 µM -0.812742752962741 0.202562254314007 no 2704 0.208182781840761 812 771486
SGTC_3291 9121177 71.43 µM -0.813329162002961 0.202391949851659 no 2705 0.208014680789398 883 17015612
SGTC_1475 4092-1048 11.7 µM -0.813459172082537 0.202354204023555 no 2706 0.207977422725059 897 2881759
SGTC_2822 7994718 71.43 µM -0.813750194222125 0.20226972682286 no 2707 0.207894036383914 912 1018011
SGTC_3279 9140807 49.47 µM -0.81390729165192 0.2022241337307 no 2708 0.207849031588905 894 45595718
SGTC_2504 purpurogallin 52.29 µM -0.814209112581902 0.202136555984224 no 2709 0.207762582992011 866 5281571 An antioxidant.
SGTC_1156 4092-0367 4.88 µM -0.816857738675952 0.201368992320356 no 2710 0.207004865727418 869 1357585
SGTC_1024 4507-0395 26 µM -0.816903633296393 0.201355707617523 no 2711 0.206991750652212 873 4201836
SGTC_2764 methyldopa 94.69 µM -0.817570600637873 0.201162705879197 no 2712 0.206801210243864 871 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2290 7904846 200 µM -0.818560615924395 0.200876427710802 no 2713 0.206518572458495 871 2962154
SGTC_2113 5491891 107.031 µM -0.819063645136782 0.200731062777768 no 2714 0.20637505121601 867 789979
SGTC_1730 st033808 45.1 µM -0.820058103243162 0.200443871030507 no 2715 0.206091492443503 880 1045166
SGTC_1236 0330-0013 258 µM -0.821182661492325 0.200119404893018 no 2716 0.205771115543982 892 4617066
SGTC_945 3381-0768 11.3 µM -0.82265744774125 0.19969436711999 no 2717 0.205351409953016 886 1126236 YIL048W NEO1
SGTC_3020 9089140 49.47 µM -0.823598898471305 0.199423322476678 no 2718 0.205083751035099 893 17217859
SGTC_1345 1488-0192 31.4 µM -0.824594231387354 0.199137006080058 no 2719 0.204800998763312 871 658348
SGTC_349 k015-0014 24 µM -0.826212415135061 0.198672049980917 no 2720 0.204341803392082 889 2196908
SGTC_1825 st052143 62.6 µM -0.826583362057379 0.198565557339851 no 2721 0.204236625438074 892 674173
SGTC_1106 tegaserod maleate 11.7 µM -0.826966772519778 0.198455522818778 no 2722 0.204127947471125 879 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1662 st014054 52 µM -0.829123874586782 0.197837144614435 no 2723 0.20351715769106 890 2838777
SGTC_2794 7785382 27.27 µM -0.829510406503849 0.197726460311846 no 2724 0.203407825327544 866 2205081
SGTC_3106 9121286 49.47 µM -0.830078588105757 0.197563828154544 no 2725 0.203247176128791 862 15943471
SGTC_2084 5306078 60.6385 µM -0.83053053594441 0.197434523663606 no 2726 0.203119445267607 908 679340
SGTC_1205 4161-2785 76 µM -0.830676822795471 0.197392681244345 no 2727 0.203078111505193 884 3498106
SGTC_2360 9040895 200 µM -0.831727153754291 0.197092412655471 no 2728 0.202781485034659 883 4914414
SGTC_1827 berberine 7.24 µM -0.833343763553649 0.19663079677455 no 2729 0.202325440573452 861 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_478 N-arachidonylglycine 10 µM -0.8341569689269 0.196398837328871 no 2730 0.20209626800104 846 5283389
SGTC_299 1273-0059 1.44 µM -0.834516268425507 0.1962964032598 no 2731 0.201995061907572 868 2848077
SGTC_362 0310-0100 9.03 µM -0.834851104571941 0.19620097270318 no 2732 0.201900773869284 878 790235
SGTC_2143 5623677 140.463 µM -0.83708040318422 0.195566325021097 no 2733 0.201273687472569 853 5375313
SGTC_2015 5119600 184 µM -0.837202275834923 0.195531665690105 no 2734 0.201239439228056 883 2828786
SGTC_3272 9137413 49.47 µM -0.837686534528695 0.195393984349413 no 2735 0.20110338899841 894 17614870
SGTC_378 3970-0959 8.33 µM -0.839769616371944 0.194802407619097 no 2736 0.200518786134 888 6615653
SGTC_1571 st070080 73.4 µM -0.841151645705929 0.194410525389039 no 2737 0.200131492698449 877 4315245
SGTC_1954 st077032 68.9 µM -0.844159557890819 0.193559275405331 no 2738 0.199290125137572 894 698907
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.845283235619033 0.193241854706842 no 2739 0.198976359414261 879 6708514
SGTC_1818 st052136 56.3 µM -0.845718108532199 0.193119095494297 no 2740 0.198855009332483 867 674169
SGTC_564 3555-0129 330 µM -0.846840561056506 0.192802461214516 no 2741 0.198541998305542 864 563260
SGTC_2864 9034755 47.6 µM -0.846908624244728 0.192783271374403 no 2742 0.198523027529516 875 4930451
SGTC_3262 9137218 49.47 µM -0.847410964203084 0.192641676963757 no 2743 0.198383047648715 836 17650664
SGTC_675 1309-0189 238 µM -0.850278352968704 0.191834664398429 no 2744 0.197585174358469 876 4246530
SGTC_1267 0828-0272 9.49 µM -0.850414418173987 0.191796421019167 no 2745 0.197547361424965 891 745334
SGTC_898 1000-0849 28.3 µM -0.850722918488612 0.191709729188505 no 2746 0.197461644456954 895 6751807
SGTC_227 fluconazole 33.516 µM -0.851154632883212 0.191588453200084 no 2747 0.197341730158191 907 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_471 1-acyl-paf 4 µM -0.851255493190216 0.191560126581078 no 2748 0.197313721241926 868 16759367
SGTC_2395 5646831 180.19 µM -0.85221593298755 0.19129051560123 no 2749 0.197047127510204 896 6808628
SGTC_1150 3909-7983 10.9 µM -0.852637716040703 0.191172187815614 no 2750 0.196930120153693 888 23965914
SGTC_738 1315-0003 72.4 µM -0.852958935093569 0.191082102546892 no 2751 0.196841038601081 902 6251474
SGTC_2619 obliquin 87.91 µM -0.853148087711679 0.191029067236996 no 2752 0.196788593574294 880 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2665 lovastatin 100 µM -0.854461545922975 0.190661044018004 no 2753 0.196424653614449 886 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1261 0712-0010 12.7 µM -0.854625811897086 0.190615048299607 no 2754 0.196379166643854 893 2840123
SGTC_1847 st056231 15 µM -0.855245225367307 0.190441669106473 no 2755 0.196207701996669 874 5393180
SGTC_2341 7987486 176.74 µM -0.855959385859071 0.19024188963941 no 2756 0.196010122400075 861 1258686
SGTC_554 4483-2211 187 µM -0.856094053845462 0.190204232010534 no 2757 0.195972878693363 900 747107
SGTC_1695 st026914 34.495 µM -0.859569590347305 0.189233941824959 no 2758 0.195013171960241 894 3289191
SGTC_2081 5214970 32.255 µM -0.859967719477214 0.189122988165284 no 2759 0.194903418476413 897 2063512
SGTC_836 0330-0104 1.35 µM -0.860395892965498 0.189003706237969 no 2760 0.194785424502475 863 46494820
SGTC_283 0987-0079 11.7 µM -0.861085032901178 0.18881182079544 no 2761 0.19459560592901 882 411556
SGTC_3069 9117009 49.47 µM -0.862267506426097 0.188482850453295 no 2762 0.19427016460345 863 41904981
SGTC_990 3985-0011 41.3 µM -0.862420964712984 0.188440183480133 no 2763 0.194227953999848 894 5399565 YGL099W LSG1
SGTC_2349 9023730 187.07 µM -0.862445240252547 0.188433434544846 no 2764 0.194221277223559 902 4126287
SGTC_97 0535-0701 19.132 µM -0.86259223930899 0.188392569961482 no 2765 0.1941808493961 875 2832013 YGL099W LSG1
SGTC_2036 5160441 105 µM -0.86274316300898 0.188350620045607 no 2766 0.194139347542294 881 134534 YIL048W NEO1
SGTC_1555 citronellol 128 µM -0.863106261356076 0.188249718849818 no 2767 0.194039522840849 878 8842 A terpine precursor.
SGTC_843 0310-0051 143 µM -0.863869852970934 0.188037633648369 no 2768 0.193829694712558 886 2065037
SGTC_1256 0570-0116 285 µM -0.864946875029397 0.187738744958708 no 2769 0.19353397393116 900 410638
SGTC_2174 5790901 200 µM -0.865738625643813 0.187519210351695 no 2770 0.193316756490204 907 786020
SGTC_670 4204-0025 119 µM -0.866634583981124 0.187270972715773 no 2771 0.193071129089946 887 719039
SGTC_3117 9124945 49.47 µM -0.866805984451561 0.187223507010735 no 2772 0.193024161293175 879 17592065
SGTC_2229 7354935 190 µM -0.866980080195151 0.187175302523766 no 2773 0.192976462070571 895 318112
SGTC_293 4049-0273 38.5 µM -0.867586022419016 0.187007586111828 no 2774 0.19281050051662 866 1380311
SGTC_1684 st024538 14.6195 µM -0.868521769141124 0.186748767098663 no 2775 0.192554380149348 893 6732859
SGTC_632 0781-2353 4.65 µM -0.868646921441534 0.186714167931802 no 2776 0.192520140870714 913 6811515 YHR007C ERG11
SGTC_630 4356-0227 183 µM -0.871336874750349 0.18597147235729 no 2777 0.191785120982788 894 779312
SGTC_685 1278-0033 54.9 µM -0.872358619937817 0.185689849390063 no 2778 0.191506383721746 904 3590572
SGTC_2517 totarol 10 µM -0.872399270579462 0.185678650355349 no 2779 0.191495299157022 879 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2011 4012611 177 µM -0.872952941156506 0.185526158792288 no 2780 0.191344364115677 908 2049887
SGTC_185 k048-0037 25.491 µM -0.875585281801872 0.184802225063351 no 2781 0.190627764787242 873 6827589
SGTC_1207 2099-0101 141 µM -0.876221773074178 0.184627444238138 no 2782 0.19045474107085 891 5837381
SGTC_2804 7954240 19.48 µM -0.878273326981703 0.184064786409002 no 2783 0.189897703559478 887 828705
SGTC_2048 5246248 200 µM -0.878983707530047 0.183870206984107 no 2784 0.18970505487618 872 677046
SGTC_1765 st044815 90.4 µM -0.880607306973738 0.183425970164639 no 2785 0.189265201156215 910 645695
SGTC_2771 fluoxetine 41.05 µM -0.880972261162927 0.183326206378504 no 2786 0.189166416925849 881 3386 A selective serotonin reuptake inhibitor.
SGTC_1103 duloxetine 36.1 µM -0.882131651872163 0.183009500147217 no 2787 0.188852808729723 915 60835 A selective serotonin reuptake inhibitor.
SGTC_2313 7726885 200 µM -0.882955285419248 0.182784718919225 no 2788 0.188630215576514 907 726423
SGTC_3051 9093778 49.47 µM -0.883740750964945 0.182570514903094 no 2789 0.188418088355381 925 17217378
SGTC_2100 5377183 190 µM -0.884124583268792 0.182465897185212 no 2790 0.188314481993721 869 2844202
SGTC_1652 st011932 78 µM -0.884406280329142 0.182389141383512 no 2791 0.188238466967926 898 1551076
SGTC_212 3807-4682 38.772 µM -0.885587097796835 0.182067616042408 no 2792 0.187920033318514 896 3125501 YBL034C STU1
SGTC_72 0744-0168 198.391 µM -0.888100780668584 0.181384345134128 no 2793 0.187243271385874 928 677577
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.889380130753008 0.181037208660584 no 2794 0.186899409825679 893 1273210
SGTC_3192 9110362 49.47 µM -0.891219154336954 0.180538941197573 no 2795 0.186405805241556 930 16649480
SGTC_1650 st011916 45.8 µM -0.891610728577484 0.180432958733915 no 2796 0.186300808817287 917 242528
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.89378816696454 0.179844331134266 no 2797 0.185717620768673 886 4330530
SGTC_2095 5432005 200 µM -0.894706627978821 0.179596405382761 no 2798 0.185471967340366 917 783734
SGTC_2979 9012552 45.46 µM -0.894919297426207 0.179539028869012 no 2799 0.185415115111963 916 17100905
SGTC_2087 5276107 200 µM -0.895310000064618 0.179433650455072 no 2800 0.18531069804869 891 144405
SGTC_128 0906-2981 13.371 µM -0.897276157029913 0.178903938541609 no 2801 0.184785787989945 897 6740226
SGTC_2832 7992762 51.95 µM -0.897532259573078 0.178835013228155 no 2802 0.184717483723338 896 2985177
SGTC_421 streptovitacin 30 mM -0.902340012900432 0.17754419779598 no 2803 0.183438138183297 932 91467 include heat shock
SGTC_603 3794-0023 45.9 µM -0.902638782936576 0.177464176702731 no 2804 0.183358818042634 923 3802260
SGTC_2094 5332512 191.667 µM -0.903950210349616 0.177113199802486 no 2805 0.183010901569572 906 755774
SGTC_2205 7238770 200 µM -0.904487659667134 0.176969489175563 no 2806 0.182868437477007 894 279867
SGTC_1127 asiatic acid 681.4 nM -0.908081342910102 0.176010454902131 no 2807 0.181917623438301 926 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2677 mitomycin C 100 µM -0.908414038320321 0.175921836313265 no 2808 0.181829755769452 930 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_438 sphingosine 6.67 µM -0.908767693680939 0.175827665703545 no 2809 0.181736381514312 907 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1982 st072467 71.9 µM -0.909384826711867 0.175663413298295 no 2810 0.181573514134222 919 3163533
SGTC_3094 9117742 49.47 µM -0.909668177378531 0.175588030971059 no 2811 0.18149876575924 911 17149698
SGTC_2678 equilin 100 µM -0.910747817399742 0.175300992522268 no 2812 0.181214131484387 857 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1067 clotrimazole 1.36 µM -0.912753076797368 0.174768654332298 no 2813 0.180686210983228 891 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_557 1315-0110 16.2 µM -0.913561549368424 0.174554318891539 no 2814 0.180473639127507 903 6833801
SGTC_1418 3966-3099 2.4 µM -0.913866515969685 0.17447351209342 no 2815 0.180393494963264 883 740335
SGTC_2971 9092186 9.93 µM -0.914304898310415 0.174357395848605 no 2816 0.1802783287314 895 25236400
SGTC_912 3474-0017 2.18 µM -0.916843015316354 0.173686079044811 no 2817 0.179612454149706 915 3360550
SGTC_1275 0867-0008 21.1 µM -0.91845267459106 0.173261187056652 no 2818 0.179190962287278 907 3422836
SGTC_3232 9132874 49.47 µM -0.919273939144789 0.173044658043613 no 2819 0.178976152727926 893 3784940
SGTC_2655 perillic acid 100 µM -0.919728916392579 0.172924776079832 no 2820 0.178857218879797 916 5702197 An apoptosis inducer.
SGTC_1764 st044502 93.5 µM -0.920406401744838 0.172746363546345 no 2821 0.178680212257237 902 8407
SGTC_1939 st074455 53.6 µM -0.92120582332565 0.172535990657509 no 2822 0.178471489269253 901 1644229
SGTC_168 3970-0862 530.542 µM -0.922886325597009 0.172094288716858 no 2823 0.178033223736342 900 3135186
SGTC_1649 st011737 51.3 µM -0.923044624622109 0.172052718749257 no 2824 0.177991975240782 853 1761035
SGTC_1608 st001473 40.5 µM -0.923060749288095 0.172048484706145 no 2825 0.17798777392195 921 7292267
SGTC_1950 st077106 7.18 µM -0.924151200364592 0.171762306493309 no 2826 0.17770379949663 899 13831864
SGTC_1989 st071868 50.2 µM -0.924646293443949 0.171632474575157 no 2827 0.177574962150294 894 16414057
SGTC_179 1273-0063 6.77 µM -0.925530904364215 0.171400652653212 no 2828 0.177344907954649 933 3108139
SGTC_702 1488-0190 94 µM -0.927113051342475 0.170986533150396 no 2829 0.176933920249615 884 949357
SGTC_2379 9035213 200 µM -0.92715281253987 0.170976134096405 no 2830 0.176923599408843 885 646551
SGTC_2621 lithochol-11-enic acid 100 µM -0.927507319448265 0.170883435043918 no 2831 0.17683159663069 931 6708711
SGTC_1056 3448-1962 115 µM -0.931213795999589 0.169916164900776 no 2832 0.175871491438779 916 715507
SGTC_3221 9128209 49.47 µM -0.932123654784921 0.169679258915629 no 2833 0.175636312289324 923 16460723
SGTC_562 3772-2733 112 µM -0.934931885044673 0.168949398153097 no 2834 0.174911701883543 912 2876874 YIL048W NEO1
SGTC_2913 7966556 36.57 µM -0.937717715655313 0.168227354753996 no 2835 0.174194748578268 864 2976516
SGTC_2388 9080168 200 µM -0.940014951039549 0.167633443214693 no 2836 0.173604945853104 911 15943073
SGTC_1955 wogonin 32.4 µM -0.942278014641974 0.167049688363942 no 2837 0.173025160565085 897 5281703 A flavanone.
SGTC_1138 3761-0006 1.03 µM -0.94376549795323 0.166666708454253 no 2838 0.172644747620794 919 12061087
SGTC_3186 9110464 49.47 µM -0.944253475586029 0.166541193175119 no 2839 0.172520067168749 903 17018021
SGTC_1470 k295-0292 231 µM -0.944590424237072 0.166454560470859 no 2840 0.172434008814451 936 5045612
SGTC_2022 5136654 200 µM -0.946077463177364 0.16607257621699 no 2841 0.172054538846564 931 1713771
SGTC_1791 st048313 56.1 µM -0.947341309933756 0.165748370218922 no 2842 0.171732443548358 867 1204976
SGTC_100 0086-0128 49.5915 µM -0.948080190488657 0.165559019894784 no 2843 0.171544316051337 912 93297
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.948212505505406 0.16552512676595 no 2844 0.171510641032284 896 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3171 9103192 49.47 µM -0.949580176026509 0.165175054347119 no 2845 0.171162807660532 919 13018434
SGTC_2951 9072950 58.06 µM -0.949767219262624 0.165127215563158 no 2846 0.171115272902098 907 16488155
SGTC_1173 0443-0020 122 µM -0.950710675182392 0.16488605095218 no 2847 0.170875633793226 932 5331295
SGTC_84 0443-0269 128.823 µM -0.951647988975894 0.164646682383282 no 2848 0.170637767548136 883 6150058
SGTC_2592 piperlongumine 83.33 µM -0.953925439486292 0.164066012143709 no 2849 0.170060692638253 944 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_875 0709-0210 25.7 µM -0.954307171360779 0.163968814017735 no 2850 0.16996408952519 927 6251364
SGTC_180 1486-1293 102.781 µM -0.95464380463146 0.163883130089887 no 2851 0.16987892850173 910 4140536
SGTC_3335 9143315 29.6265 µM -0.954734107250895 0.163860150130249 no 2852 0.169856088523455 891 4899691
SGTC_539 4859-0462 2.54 µM -0.956067807697052 0.16352099727806 no 2853 0.169518988863429 906 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_970 1315-0089 19.5 µM -0.957814342547876 0.163077552723476 no 2854 0.16907819278374 903 6811083 YLR033W RSC58
SGTC_2610 ononetin 44.17 µM -0.958798571836213 0.162828001943701 no 2855 0.168830114410576 945 259632
SGTC_713 1488-1073 324 µM -0.961468720710827 0.162152238630381 no 2856 0.168158272781084 931 3312542
SGTC_2252 omeprazole 400 µM -0.962287168303371 0.161945471489735 no 2857 0.167952686410439 904 4594 A proton pump inhibitor.
SGTC_375 3970-0961 9.27 µM -0.965896182575182 0.161035763704239 no 2858 0.167048066372159 898 2898222
SGTC_3141 9094609 49.47 µM -0.968506660972612 0.160379834902261 no 2859 0.166395696995004 929 25236309 YDL196W YDL196W
SGTC_724 3910-0327 137 µM -0.969453944568774 0.160142245489296 no 2860 0.166159374218589 930 2885483
SGTC_2922 7999257 32.47 µM -0.969714709657634 0.160076883073356 no 2861 0.166094358143896 936 2988377
SGTC_2074 5212007 75.395 µM -0.973804697971167 0.159053984397495 no 2862 0.165076760010045 886 758611
SGTC_1012 4112-3522 18 µM -0.97458186909589 0.158860100553364 no 2863 0.164883855412679 910 3112398
SGTC_2755 lomerizine 42.69 µM -0.976082615850674 0.158486142088868 no 2864 0.164511762692744 907 3949 A calcium channel blocker.
SGTC_1729 st035615 45.989 µM -0.977895608625539 0.158035148370963 no 2865 0.164062978638681 904 17385451
SGTC_1239 0337-0584 35.4 µM -0.979474960590296 0.157642961628465 no 2866 0.16367267737486 934 914301 YML130C ERO1
SGTC_2749 bexarotene 57.39 µM -0.980589324192903 0.157366626479525 no 2867 0.163397650525856 929 82146 An retinoic acid receptor inhibitor.
SGTC_307 1501-1223 22.3 µM -0.980887564880107 0.157292724066251 no 2868 0.163324095163351 916 2830329
SGTC_3103 9120822 49.47 µM -0.983470262352041 0.156653700214648 no 2869 0.162688022115862 923 17141819
SGTC_2167 5876490 200 µM -0.983476605447896 0.156652132880974 no 2870 0.162686461908988 913 686534
SGTC_2483 5729050 27.16 µM -0.985399324259712 0.15617751857305 no 2871 0.162213980726883 917 2865180
SGTC_2346 9031566 143.75 µM -0.985759249233511 0.15608877813262 no 2872 0.162125633588824 927 4771086
SGTC_2096 5468907 200 µM -0.985962410327188 0.15603870290921 no 2873 0.162075779530283 918 759785
SGTC_883 0850-0245 24.6 µM -0.986310273461719 0.155952986058737 no 2874 0.161990439969158 895 6823229 YPR165W RHO1
SGTC_3035 9091303 49.47 µM -0.986336397649917 0.155946550058574 no 2875 0.161984032231676 938 25237002
SGTC_154 3389-1638 511.116 µM -0.987789832663554 0.155588755127434 no 2876 0.161627794007311 963 5238686
SGTC_1813 st051246 8.6015 µM -0.988922169428315 0.155310381131723 no 2877 0.161350611438282 899 5291959
SGTC_2825 7998094 58.44 µM -0.995022402164014 0.153816356744469 no 2878 0.159862684465239 928 2987815
SGTC_2852 9023854 51.95 µM -0.995584406663907 0.153679194876491 no 2879 0.159726057150308 918 19798528
SGTC_1531 st059297 52.4 µM -0.996211745796612 0.153526183223452 no 2880 0.159573636786752 922 7566702
SGTC_2929 9013348 24.6 µM -0.996263992485482 0.153513444505861 no 2881 0.159560947056323 930 2995952
SGTC_2298 7976326 193.81 µM -0.997181512789996 0.153289850027711 no 2882 0.159338206414445 919 2235818
SGTC_199 4063-0024 41.6 µM -0.997739230086867 0.153154042991697 no 2883 0.15920291243072 925 306215
SGTC_477 mead ethanolamide 10 µM -0.99779108611878 0.153141419833676 no 2884 0.159190336747159 923 16061185
SGTC_2387 9077560 195.08 µM -0.999992106310229 0.152606267861624 no 2885 0.158657163980829 937 5303272
SGTC_878 0828-0289 13.7 µM -1.00076391014383 0.15241890706861 no 2886 0.158470480642541 921 745350 YLR208W SEC13
SGTC_3031 9088762 49.47 µM -1.00653521262715 0.151022723513739 no 2887 0.157079090924776 956 205253
SGTC_2784 7567673 72.73 µM -1.00855315524378 0.150536560830129 no 2888 0.156594491513839 914 3471247
SGTC_1677 st019204 53.9 µM -1.01072894418434 0.150013539018159 no 2889 0.156073089921727 935 3945625
SGTC_1808 st050063 61.5 µM -1.01302073470676 0.149463944199522 no 2890 0.155525128544349 929 4011993
SGTC_1656 st012921 11 µM -1.01312453164848 0.149439084483947 no 2891 0.155500341034434 906 6732821
SGTC_492 tmb-8 126 µM -1.01566633584942 0.148831175179069 no 2892 0.154894152015549 918 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_3163 9099914 49.47 µM -1.01577956150658 0.148804134124424 no 2893 0.154867185452149 955 16268368
SGTC_2475 5812728 15.03 µM -1.01793419197458 0.148290181445894 no 2894 0.154354615583519 931 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2077 5212015 200 µM -1.01895207723824 0.148047794672291 no 2895 0.154112859150947 920 780900
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.019225419059 0.147982749576198 no 2896 0.154047980823437 901 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1022 4477-0945 21.3 µM -1.02101542974083 0.147557267043001 no 2897 0.153623564232611 916 4648966
SGTC_1663 st014140 55.4 µM -1.02310952048696 0.147060546339112 no 2898 0.153128033016906 937 4207120
SGTC_79 0052-0007 94.094 µM -1.02452512416683 0.146725399402039 no 2899 0.152793655092316 900 2801472
SGTC_1368 1852-0141 284 µM -1.02471901639148 0.146679534973701 no 2900 0.152747893793262 942 2838987
SGTC_534 k292-0788 63.4 µM -1.02629743391361 0.146306524580926 no 2901 0.152375703238139 948 4146317
SGTC_1626 st003712 1.76 µM -1.0263863472204 0.146285531625543 no 2902 0.152354755421092 955 24207035
SGTC_1558 st069300 45.6 µM -1.02822096419388 0.145852819209849 no 2903 0.151922949565472 913 24208000
SGTC_41 0478-0632 82.643 µM -1.0303557026684 0.145350404051665 no 2904 0.15142152977007 916 3750424
SGTC_103 0844-0104 51.839 µM -1.03300805549444 0.144727790967731 no 2905 0.150800064443304 943 5375804
SGTC_251 melphalan 456.522 µM -1.03364761500761 0.144577929998247 no 2906 0.150650465509413 937 460612 A DNA alkylator.
SGTC_3105 9121040 49.47 µM -1.03434906483977 0.144413687194684 no 2907 0.150486503530242 883 41448907
SGTC_1751 st044839 27.194 µM -1.03690088470414 0.143817245733937 no 2908 0.149891025795926 919 5291326
SGTC_50 0929-0078 56.389 µM -1.03904787965536 0.143316713855773 no 2909 0.149391234542074 899 1377751
SGTC_1432 4049-0298 68.4 µM -1.03987554534776 0.143124073550298 no 2910 0.149198862644909 949 741646
SGTC_1619 st003326 88.7 µM -1.04035390379987 0.143012814777632 no 2911 0.149087754667414 872 2849032
SGTC_2262 9014885 67.46 µM -1.04213554193453 0.142598947572695 no 2912 0.148674421192726 936 6457424
SGTC_1970 st070122 35.8 µM -1.04333324847122 0.142321180945764 no 2913 0.148396988667803 945 102928
SGTC_763 3453-1109 128 µM -1.04430333698444 0.142096470942776 no 2914 0.148172534737865 940 1560353
SGTC_207 4185-0010 4.486 µM -1.04443629661412 0.142065691075111 no 2915 0.148141788954588 923 3761753
SGTC_3350 9150499 3.57 µM -1.04522502661986 0.141883194575049 no 2916 0.147959489629827 956 4910996 YPR165W RHO1
SGTC_981 1488-1094 54.9 µM -1.04611123983341 0.14167833185168 no 2917 0.147754838214976 932 3449522
SGTC_2836 9010338 19.48 µM -1.04689496634004 0.14149732764156 no 2918 0.147574011858779 945 2994051
SGTC_2985 9022375 71.43 µM -1.04863368430445 0.141096324655869 no 2919 0.147173373265622 960 4939335
SGTC_2720 fluspirilene 36.88 µM -1.04926361339761 0.140951233579366 no 2920 0.14702840395096 951 3396 An atypical antipsychotic.
SGTC_1991 st073000 8.92 µM -1.04936728515095 0.140927364647175 no 2921 0.147004554535675 943 4301969 YIL048W NEO1
SGTC_1293 1000-1278 195 µM -1.04966233005594 0.140859449801464 no 2922 0.146936694426612 941 678847
SGTC_2355 9061122 103.12 µM -1.05145617064603 0.140447012932902 no 2923 0.146524564649447 972 5302957
SGTC_1387 3342-1166 1.8 µM -1.05345741960478 0.139987857565517 no 2924 0.146065699866575 921 3418228
SGTC_1790 st045711 43.5 µM -1.05399452051341 0.139864801949944 no 2925 0.14594271291724 877 585119
SGTC_3086 9117350 49.47 µM -1.05467934388013 0.139708008189913 no 2926 0.145786000994655 909 2679265
SGTC_658 3253-0951 102 µM -1.0547626964349 0.139688932363663 no 2927 0.145766934692123 954 1184878
SGTC_2049 5262831 67.185 µM -1.05750802952347 0.139061632934338 no 2928 0.145139896004865 940 763417
SGTC_959 1222-0044 107 µM -1.05873262743056 0.138782435800863 no 2929 0.144860782091677 920 6083612
SGTC_1824 st053723 68.6 µM -1.0592088341153 0.138673968192784 no 2930 0.144752341342286 946 675225
SGTC_13 0199-0087 65 µM -1.05938552287689 0.138633737739474 no 2931 0.144712120071229 943 4589825
SGTC_2035 5154463 94.595 µM -1.05950843122485 0.138605757295728 no 2932 0.144684145764914 948 2769623
SGTC_1501 4491-0275 38.4 µM -1.05952129239601 0.138602829634993 no 2933 0.144681218734551 934 5104718
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.06279326312223 0.137859381038751 no 2934 0.14393785766389 933 6312947
SGTC_1201 1889-3372 45.9 µM -1.0628684025852 0.137842340064012 no 2935 0.14392081699678 941 5392199
SGTC_2197 6588183 93.1375 µM -1.06361784297773 0.137672452171504 no 2936 0.143750927996289 927 884136
SGTC_507 nimesulide 162 µM -1.0662144268808 0.137084947639864 no 2937 0.143163360989332 950 4495 A COX2 inhibitor.
SGTC_1755 st041960 45.185 µM -1.0679818586111 0.136686028702516 no 2938 0.142764347575983 956 2257073
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.06801845101335 0.136677777993753 no 2939 0.142756094467365 963 75037 A free radical scavenger.
SGTC_1171 0368-0077 21.4 µM -1.06983331246677 0.136268997497928 no 2940 0.142347172386885 945 3239779
SGTC_536 3852-0578 10.6 µM -1.07140307264975 0.135916099133155 no 2941 0.141994115935998 956 2869208
SGTC_109 0132-0036 33.701 µM -1.07186293422639 0.135812836096487 no 2942 0.141890800339744 885 67274 A color developer.
SGTC_2476 5806916 10.51 µM -1.07337802712772 0.135472998476462 no 2943 0.141550769550374 922 2870194
SGTC_4 0960-0234 25.671 µM -1.07764314694236 0.134519456715151 no 2944 0.140596519612774 922 6821112
SGTC_1467 k284-1082 293 µM -1.08164247053515 0.133629533259873 no 2945 0.13970571260343 945 3334705
SGTC_1388 3346-4487 254 µM -1.08361776641595 0.133191490176738 no 2946 0.139267155079233 980 3345614
SGTC_456 gingerol 170 µM -1.08503487252054 0.132877841062465 no 2947 0.13895310520307 951 442793 A herb.
SGTC_2039 Aminomethylbenzodioxan 200 µM -1.08929794289094 0.131937360414302 no 2948 0.138011259815122 951 15053
SGTC_852 0418-0143 439 µM -1.09046974543758 0.131679654185039 no 2949 0.137753136725931 920 5369229
SGTC_269 exalamide 29 µM -1.0927455603061 0.131180143279204 no 2950 0.137252764974281 949 3316 A derivative of salicylamide.
SGTC_161 4065-0411 162.148 µM -1.09705766085656 0.130237287737836 no 2951 0.136308093440789 955 1906281 YLR208W SEC13
SGTC_522 1273-0010 11.6 µM -1.10030856671831 0.129529573148857 no 2952 0.135598850423162 906 5705015
SGTC_2069 5228469 200 µM -1.10081162011254 0.129420298095913 no 2953 0.135489326661693 964 2835210
SGTC_140 0062-0056 502.533 µM -1.10134444799607 0.129304625002981 no 2954 0.135373386582083 958 3758964
SGTC_1118 chelidonine 707.474 nM -1.10168886072508 0.129229893620538 no 2955 0.13529848067679 953 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2656 pseudo-anisatin 100 µM -1.10358675466468 0.128818621759957 no 2956 0.134886219724072 996 6708809 A neurotoxin.
SGTC_901 1112-0062 60.1 µM -1.10470256205358 0.128577251589364 no 2957 0.134644246445164 932 1908457
SGTC_3047 9092122 49.47 µM -1.10523629722539 0.128461905655923 no 2958 0.13452860637404 958 17173831
SGTC_2912 7964298 10.93 µM -1.10548580435506 0.128408009115575 no 2959 0.134474571079714 945 2975850
SGTC_1920 st075728 45.7 µM -1.10763669959334 0.127944040804375 no 2960 0.134009373586395 926 3400306
SGTC_64 000l-0018 272.079 µM -1.10813020288822 0.127837751995324 no 2961 0.133902794411654 942 6811119
SGTC_3303 9125618 40.5795 µM -1.11079439269306 0.127265009080971 no 2962 0.133328430310863 933 22695467
SGTC_2127 5253358 187.912 µM -1.11269890149599 0.126856676780162 no 2963 0.132918883746598 954 20612
SGTC_559 1550-0661 158 µM -1.12100187467818 0.125087154936769 no 2964 0.131143532217282 956 5830875
SGTC_2312 7706453 155.7 µM -1.12332876559597 0.124594357564479 no 2965 0.130648945594655 957 976098
SGTC_3244 9134489 49.47 µM -1.12567178667145 0.124099516999024 no 2966 0.130152235013231 974 16584271
SGTC_1277 0873-0036 22 µM -1.12760219554286 0.123692853595305 no 2967 0.129743979529651 957 5965735
SGTC_1771 st048882 4.1505 µM -1.12819274481893 0.123568634012439 no 2968 0.129619263648511 967 4580403
SGTC_1394 3474-0001 65.7 µM -1.13096142893558 0.122987417887919 no 2969 0.129035663077253 943 5017666 YIL048W NEO1
SGTC_270 tamoxifen 5.46 µM -1.13273911945392 0.122615248013537 no 2970 0.128661912256216 998 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_3010 9080089 71.4286 µM -1.13470666029574 0.122204253841492 no 2971 0.128249122889211 957 17027233
SGTC_1962 st076595 64.5 µM -1.13656129534142 0.121817730654918 no 2972 0.12786086396118 955 279619
SGTC_3112 9123419 49.47 µM -1.13723176472436 0.121678210202467 no 2973 0.127720705639762 978 17015854
SGTC_3079 9117512 49.47 µM -1.13789953493738 0.121539363083814 no 2974 0.127581217749368 1014 7185044
SGTC_1559 coumarin 343 70.1 µM -1.13815718215791 0.121485821186003 no 2975 0.12752742716274 955 108770 A hepatotoxic, DNA x-linker.
SGTC_683 panaxydol 45 µM -1.13926718478461 0.12125534015573 no 2976 0.127295865448004 950 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2827 7993847 71.43 µM -1.14040104662026 0.121020222672994 no 2977 0.127059628524173 945 2985692
SGTC_2745 rifampicin 24.3 µM -1.14215231823886 0.120657709763733 no 2978 0.12669535584173 925 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_686 1319-0111 510 µM -1.14236947251743 0.120612812198375 no 2979 0.126650237468471 973 4562600
SGTC_3289 9119912 71.43 µM -1.14267585135092 0.120549487086294 no 2980 0.126586599848423 978 17014829
SGTC_2405 ticlatone 3.52 µM -1.14527468612909 0.120013278158722 no 2981 0.126047694307266 972 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2030 5175110 200 µM -1.15367805806745 0.118290952299313 no 2982 0.124316091437833 989 2831986
SGTC_1883 5-benzylidenerhodanine 20 µM -1.15497966184532 0.118025751045755 no 2983 0.124049377580011 951 1273210
SGTC_2457 5731572 11.68 µM -1.15529737686017 0.117961080644705 no 2984 0.123984334893491 961 2865357
SGTC_1218 1348-1416 30.7 µM -1.15704976121182 0.117604835945398 no 2985 0.123626015239864 949 6787668
SGTC_2645 abamectin 100 µM -1.15754233879523 0.117504836415429 no 2986 0.123525425891144 910 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1237 0330-0133 46.1 µM -1.15765695470797 0.117481576560057 no 2987 0.123502028380238 975 X1237 YHR072W ERG7
SGTC_3353 9151644 39.2805 µM -1.15774191113699 0.11746433782707 no 2988 0.123484687512656 958 4909158
SGTC_707 0865-0008 204 µM -1.15830486296524 0.11735015304238 no 2989 0.123369823784784 981 723043
SGTC_2105 5350118 200 µM -1.15834959490418 0.117341083335072 no 2990 0.123360699967793 967 2133313
SGTC_2961 9083290 32.55 µM -1.15957910065005 0.117091986941623 no 2991 0.123110107034307 961 17741490
SGTC_992 3909-8734 162 µM -1.16169271773761 0.116664646745979 no 2992 0.12268015240372 984 4288319
SGTC_512 prima-1 270 µM -1.16603924491485 0.115789325385354 no 2993 0.121799289332275 967 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2687 chenodiol 100 µM -1.16657293184299 0.115682171684099 no 2994 0.121691439920868 949 5702181 A cholesterol synthesis inhibitor.
SGTC_3157 9099274 49.47 µM -1.16684480329895 0.115627612401329 no 2995 0.121636524947884 951 17217662
SGTC_3063 1327-0034 4 µM -1.16792140501145 0.115411739021152 no 2996 0.121419234565825 947 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_465 cgp-37157 41 µM -1.17034285169929 0.114927252746386 no 2997 0.120931511851954 948 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_359 0081-0058 15.9 µM -1.17039285850414 0.114917262587177 no 2998 0.120921454135946 957 3494159
SGTC_2161 5662504 8.5105 µM -1.17044330171615 0.114907185870099 no 2999 0.120911309243064 922 2859334
SGTC_230 MPP+ 141.667 µM -1.17599717589191 0.113801565461562 no 3000 0.119798002293366 983 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_791 1348-1292 225 µM -1.17771894867132 0.113460353436003 no 3001 0.119454335078776 992 5437054
SGTC_2589 lobaric acid 100 µM -1.17868458134917 0.11326930897571 no 3002 0.119261898758822 984 73157 A novel microtubule depolymerizer.
SGTC_3248 9135562 49.47 µM -1.18090736271524 0.112830417771074 no 3003 0.118819763063503 963 17650701
SGTC_2079 5212404 121 µM -1.18138758943573 0.112735756052493 no 3004 0.118724392963018 976 758462
SGTC_589 1227-0070 34.1 µM -1.18450727295001 0.112122188394254 no 3005 0.118106159502353 965 2841384
SGTC_1919 st067113 52.3 µM -1.19419498174358 0.11023207191607 no 3006 0.11620085282108 980 1268243
SGTC_1232 0279-0259 161 µM -1.19535772240063 0.110006761110443 no 3007 0.115973648124548 964 1560000
SGTC_1811 st050069 61.5 µM -1.19702853410841 0.109683577362909 no 3008 0.11564771658538 965 3877702
SGTC_807 1315-0151 48 µM -1.19871847760147 0.109357386931848 no 3009 0.115318715377597 984 4011080
SGTC_1857 st056007 79.3 µM -1.19895741987337 0.109311322929037 no 3010 0.115272251404658 961 619834
SGTC_1183 1254-0324 198 µM -1.20006277670338 0.109098410337551 no 3011 0.115057480320494 960 5799357
SGTC_138 0850-0259 40.9225 µM -1.20133581695753 0.108853568222742 no 3012 0.114810481066721 959 6813004
SGTC_1545 lovastatin 49.4 µM -1.20280985003627 0.108570563271299 no 3013 0.114524956100526 962 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2149 5554786 194.827 µM -1.20412132779706 0.108319213171592 no 3014 0.114271343824317 987 745063 YPR165W RHO1
SGTC_2310 7668677 200 µM -1.20724666367046 0.107721918395926 no 3015 0.113668582238463 979 2197143
SGTC_1340 1486-1359 257 µM -1.20782148252837 0.10761232141458 no 3016 0.113557968182897 953 4309068
SGTC_1560 lithocholic acid 53.1 µM -1.20872106109565 0.107440965900865 no 3017 0.113385013753789 941 9903 A bile acid which acts as a detergent.
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.20893523957912 0.107400197282976 no 3018 0.113343863157341 994 6708561
SGTC_1702 st027038 51 µM -1.21069833447563 0.10706501793442 no 3019 0.113005520484992 981 5521182
SGTC_1855 st056195 39.6 µM -1.21193384628379 0.106830586636496 no 3020 0.112768852383524 934 4028379
SGTC_535 2293-4129 48.2 µM -1.21223632670969 0.106773249186171 no 3021 0.112710964800402 999 396118 YIL048W NEO1
SGTC_115 0527-0192 112.043 µM -1.21233913211386 0.106753766702245 no 3022 0.112691295115384 990 4233931
SGTC_910 3454-3003 490 µM -1.21654138113106 0.105959599658166 no 3023 0.111889378694575 980 820824
SGTC_2237 6667747 47.222 µM -1.21816326263106 0.105654231147403 no 3024 0.111580968605354 1001 729940 YDL015C TSC13
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.21891420191374 0.105513059704001 no 3025 0.111438379378513 1000 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_784 4579-0127 173 µM -1.21901373748467 0.105494357942367 no 3026 0.111419489240939 976 1948547
SGTC_3228 9131799 49.47 µM -1.21971731881718 0.105362230245448 no 3027 0.111286026971451 991 17015818
SGTC_2816 7982706 58.44 µM -1.22317911553425 0.104713872232969 no 3028 0.11063102591111 972 2981853
SGTC_1466 k213-0079 57.5 µM -1.22459204645286 0.104450077200053 no 3029 0.110364483054854 1005 3657981
SGTC_3099 9120367 49.47 µM -1.22647991278509 0.104098363402879 no 3030 0.110009064945861 989 24824940
SGTC_2246 7293507 91.5585 µM -1.2273678496333 0.103933235970514 no 3031 0.109842182273994 980 887656
SGTC_2558 carylophyllene oxide 100 µM -1.23212173165919 0.103052398637353 no 3032 0.108951807333055 986 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1430 4049-0248 69.1 µM -1.23222020812379 0.103034209630305 no 3033 0.108933418264294 986 22774488
SGTC_2635 hydroquinidine 100 µM -1.23312930213363 0.102866406357411 no 3034 0.108763763348193 972 442912 An experimental heart treatment.
SGTC_2231 micatex 6.853 µM -1.23720506043633 0.10211653131433 no 3035 0.108005481655633 998 20737 An antifungal of unknown mechanism.
SGTC_691 1548-0686 185 µM -1.237321229292 0.102095216530036 no 3036 0.107983924750108 968 46495133
SGTC_947 3447-0010 211 µM -1.23801493847639 0.101968001412731 no 3037 0.1078552609033 982 748350
SGTC_2173 5763948 167 µM -1.24124605110694 0.101376987091141 no 3038 0.107257433766653 985 2867177
SGTC_1062 mesoridazine 14.2 µM -1.24623745253402 0.100468903386925 no 3039 0.106338616504521 958 4078 A neuroleptic.
SGTC_2993 9054257 71.4286 µM -1.24665104072148 0.100393926566474 no 3040 0.106262738973753 970 6470217 YGL055W OLE1
SGTC_3085 9117376 49.47 µM -1.24682756239655 0.100361938489331 no 3041 0.106230365942798 962 16480349
SGTC_569 4130-2812 160 µM -1.24721147480169 0.100292394132255 no 3042 0.106159983274404 981 743552
SGTC_3206 9114350 49.47 µM -1.24724788768707 0.100285799895119 no 3043 0.106153309448904 967 17087243
SGTC_2057 5236571 38.335 µM -1.24823226715751 0.100107652356426 no 3044 0.105973005270932 971 54684039 YBR257W POP4
SGTC_1285 0929-0069 65.5 µM -1.2504618170298 0.0997050152885264 no 3045 0.105565447553606 988 1206237
SGTC_1840 st055363 71 µM -1.25627659293954 0.0986604873486987 no 3046 0.104507852685432 1005 676033
SGTC_506 n9-isopropylolomoucine 153 µM -1.25744964800931 0.0984507419026024 no 3047 0.104295430476957 977 6610355
SGTC_1411 3909-8223 150 µM -1.25786603204405 0.0983763698715686 no 3048 0.104220105043117 991 X1411
SGTC_2490 carminic acid 95.39 µM -1.26161709769395 0.0977082310131585 no 3049 0.103543300407438 969 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_390 dec-rvkr-cmk 16.7 µM -1.26279744149414 0.0974986781968257 no 3050 0.103330992219309 983 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_3339 9145883 14.936 µM -1.27011997899506 0.0962060299690463 no 3051 0.102020947983172 947 2030670
SGTC_184 1494-0393 24.714 µM -1.27064075666292 0.0961145791800606 no 3052 0.101928240282151 989 3090647
SGTC_1433 4060-0023 7.6 µM -1.2724674082936 0.0957943165726528 no 3053 0.101603548451184 985 3840627
SGTC_1142 3253-1408 9.78 µM -1.27349509358506 0.0956144803051674 no 3054 0.101421206254384 996 256655
SGTC_352 k048-0007 5.11 µM -1.27453832070792 0.0954321785665629 no 3055 0.101236350391748 982 6811911
SGTC_2416 tofa 880 nM -1.27615127147073 0.0951508226105072 no 3056 0.100951025097508 988 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1498 4478-3555 97.6 µM -1.27643622141901 0.0951011807672991 no 3057 0.100900679451036 990 3437919
SGTC_1115 galangin 695.678 nM -1.27659689735002 0.0950731974231668 no 3058 0.100872298911297 1002 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1271 0832-2808 169 µM -1.28666070428114 0.0933325476396252 no 3059 0.0991062876082008 982 3663794
SGTC_2356 9061756 188.97 µM -1.29349079733369 0.0921646900425686 no 3060 0.0979206824405979 981 20104043
SGTC_2119 5528445 120.635 µM -1.29435739601995 0.0920172896698986 no 3061 0.0977709997440457 1008 791935
SGTC_841 0251-0215 91.2 µM -1.29490224642509 0.0919247051038527 no 3062 0.0976769767322023 997 3888614
SGTC_2226 7298446 200 µM -1.29601865819788 0.0917352126091023 no 3063 0.0974845284108485 1000 3283010
SGTC_3093 9117344 49.47 µM -1.29696371545103 0.0915750310146342 no 3064 0.0973218358476704 978 24824913
SGTC_277 nystatin 15.5 µM -1.29847241751466 0.0913197446730156 no 3065 0.0970625242440584 1015 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1947 st076332 61.6 µM -1.30197147852053 0.0907297026648546 no 3066 0.0964630678770708 993 24208416
SGTC_2489 cantharidin 73.42 µM -1.30317469522384 0.0905274609591629 no 3067 0.096257563564183 980 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.30492665627031 0.0902335827144094 no 3068 0.0959589117148602 995 688662
SGTC_529 4076-0302 30.3 µM -1.30505271352139 0.0902124649210746 no 3069 0.0959374493998749 999 5816522
SGTC_1562 morin hydrate 59.1 µM -1.30658615059047 0.0899558691241203 no 3070 0.0956766513672044 993 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_462 ag-879 158 µM -1.30904319260778 0.0895458544131687 no 3071 0.0952598601112181 1003 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_379 3970-0972 5.9 µM -1.3105211127391 0.0892998993118667 no 3072 0.0950098033467693 1001 2898042 YBL034C STU1
SGTC_452 diindolylmethane 8 µM -1.31541120607758 0.0884896739179554 no 3073 0.0941858706976327 994 3071 Inhibits expression of several cancer promoting factors.
SGTC_650 1328-0195 38 µM -1.31701933021914 0.088224428779208 no 3074 0.0939160726037332 1002 2780821
SGTC_1230 0170-0365 3.77 µM -1.3184070730007 0.0879960102450206 no 3075 0.0936837071664613 950 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_504 lovastatin 124 µM -1.32119213150158 0.0875389285325354 no 3076 0.0932186546353453 1008 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_205 1486-1330 71.903 µM -1.32314181885484 0.0872200032143653 no 3077 0.0928941099807276 1008 4118834
SGTC_3268 9137683 49.47 µM -1.32423143372036 0.0870421448837188 no 3078 0.0927130971457749 1045 1953228
SGTC_811 0416-0114 265 µM -1.32442428592269 0.0870106937665615 no 3079 0.0926810866631133 970 6612453
SGTC_1993 st073995 70.8 µM -1.32630842251226 0.0867038676072798 no 3080 0.0923687790802996 989 3098394
SGTC_329 k048-0121 21.3 µM -1.32759399796447 0.0864949799408389 no 3081 0.0921561342135804 1007 6832902
SGTC_2787 5284540 71.43 µM -1.33105781434046 0.0859340320018064 no 3082 0.0915849941773445 1005 736958
SGTC_111 0083-0039 52.457 µM -1.33351890912667 0.0855371272710939 no 3083 0.0911807871915019 976 759313
SGTC_2719 novobiocin 32.65 µM -1.34220007182026 0.0841480613697603 no 3084 0.0897655666063671 1011 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_220 paclitaxel 373.376 µM -1.34300262620036 0.0840205053563081 no 3085 0.0896355617361162 996 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2354 9060492 162 µM -1.34628252886121 0.0835007144990075 no 3086 0.0891057090470698 1010 6471895
SGTC_2702 st077768 96.8 µM -1.3464018429099 0.0834818515604149 no 3087 0.0890864784634609 974 6484119
SGTC_2998 9066762 71.4286 µM -1.34716617941721 0.0833610898432772 no 3088 0.0889633588873006 1000 4945196
SGTC_1733 st037357 54.9 µM -1.35344484024471 0.0823740550588536 no 3089 0.0879567802948708 997 1272339 YGL099W LSG1
SGTC_2172 5754775 163.918 µM -1.3536519282885 0.0823416504141608 no 3090 0.0879237257560375 979 2263357
SGTC_2652 actinonin 100 µM -1.35403919369239 0.0822810778060382 no 3091 0.0878619369122686 1001 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1327 1436-0082 2.18 µM -1.3578248972576 0.0816907180684291 no 3092 0.08725962638241 1010 15992205
SGTC_1797 st048695 56.8 µM -1.35810957676629 0.0816464532845349 no 3093 0.0872144584227741 983 592262 YIL048W NEO1
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.35948235461294 0.0814332540357522 no 3094 0.0869968951132783 959 4000243
SGTC_2714 st079313 56.9 µM -1.36270363902824 0.080934621473558 no 3095 0.086487965252914 1010 2939799
SGTC_1141 3253-0389 52.6 µM -1.36459118470529 0.0806435153256862 no 3096 0.0861907884840725 1006 5402031
SGTC_2371 9071574 200 µM -1.36469540312277 0.0806274653389848 no 3097 0.0861744025273208 1020 45596039
SGTC_1369 1866-0067 208 µM -1.36524724475122 0.0805425200793167 no 3098 0.086087676917865 982 3531355
SGTC_1129 3453-1384 223 µM -1.37397853532337 0.0792074895561725 no 3099 0.0847241731245121 1011 1084452
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.37912368720987 0.0784286703764076 no 3100 0.0839283108555468 1009 616764
SGTC_1210 3013-0140 750 nM -1.38589407506447 0.0774127040800959 no 3101 0.0828896251392656 1011 905973
SGTC_737 1950-0117 57.9 µM -1.3864129048228 0.077335262617883 no 3102 0.0828104290801438 1005 5393513
SGTC_1259 0671-0132 43 µM -1.39428659612925 0.0761672328196783 no 3103 0.081615538459568 998 X1259
SGTC_2047 4141938 200 µM -1.40042738261438 0.0752656302414638 no 3104 0.0806926874602168 1015 3807862
SGTC_1036 k216-0215 33.5 µM -1.40293044454387 0.0749004685258992 no 3105 0.0803187906452705 920 622330
SGTC_1999 st074831 12.5 µM -1.40323968341295 0.074855448858999 no 3106 0.0802726888616448 1003 17112523
SGTC_489 paxilline 115 µM -1.40886316640513 0.0740403666088172 no 3107 0.0794378164190803 1016 105008 A toxic potassium channel blocker.
SGTC_1529 apigenin 74 µM -1.4090763815043 0.0740095966051058 no 3108 0.0794062919176038 998 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2374 9071832 200 µM -1.41373597575034 0.0733395873981416 no 3109 0.07871971908282 1004 17381698
SGTC_2279 7948423 32.93 µM -1.41713807757449 0.0728533323640916 no 3110 0.0782212808549654 994 1247112
SGTC_978 1416-0512 87.4 µM -1.41988058903125 0.0724631510260674 no 3111 0.0778212239540447 1030 6814003
SGTC_1139 k015-0024 46.9 µM -1.42261208702644 0.0720761298548497 no 3112 0.0774243190716367 1014 2766652
SGTC_1688 st021091 57.6 µM -1.42327931732686 0.0719818324103969 no 3113 0.0773276001057478 1045 3656366
SGTC_3147 9097027 49.47 µM -1.42355008377749 0.0719435928790113 no 3114 0.0772883771018587 1019 25236841
SGTC_896 0964-0007 44.5 µM -1.42869276120962 0.0712202619892266 no 3115 0.0765462796478342 989 6756758
SGTC_1515 3460-0031 42.1 µM -1.42985565471575 0.0710574746883688 no 3116 0.0763792258798016 997 2876596
SGTC_1105 epirubicin 18.1 µM -1.43230074206278 0.0707161320722499 no 3117 0.0760288854112555 1004 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2713 st079149 53.4 µM -1.43282043673833 0.0706437435388321 no 3118 0.0759545796838069 1014 3103253
SGTC_2179 6298986 200 µM -1.43467654400728 0.0703856702726051 no 3119 0.0756896456253649 961 738374
SGTC_1487 3970-0795 2.82 µM -1.43848861319384 0.0698579138509326 no 3120 0.0751477330043433 997 3765103
SGTC_3247 9135149 49.47 µM -1.44338909201884 0.0691839543049271 no 3121 0.074455447565813 1005 8934436 YOR116C RPO31
SGTC_2436 5633522 8.09 µM -1.44469294490322 0.069005482816818 no 3122 0.0742720762345417 1026 5724242
SGTC_2102 5377816 72.7585 µM -1.44641110382282 0.0687708432353385 no 3123 0.0740309646400034 1004 1379702
SGTC_1276 0871-0068 94.2 µM -1.44876659125454 0.068450167580818 no 3124 0.0737013883213508 1016 3414906
SGTC_2833 9001315 45.46 µM -1.44878443760904 0.0684477423920358 no 3125 0.0736988955739422 1009 2989378
SGTC_756 0508-1999 28.3 µM -1.45216627681046 0.067989370611691 no 3126 0.0732276885235714 1012 6753853
SGTC_1392 3455-1037 33.9 µM -1.45846204668873 0.0671423645265806 no 3127 0.0723566145546611 991 981132
SGTC_1716 st033144 30.6155 µM -1.45904264417981 0.0670646661776015 no 3128 0.0722766854531747 1020 674617
SGTC_1854 st056233 32.9 µM -1.4704443192936 0.065552890330852 no 3129 0.0707207277815529 1029 5393174
SGTC_939 1165-0479 45.3 µM -1.47470205444523 0.064995172212799 no 3130 0.0701463317565859 999 1377347
SGTC_2753 fluvastatin 17.09 µM -1.47604343798534 0.0648202302652362 no 3131 0.0699661157734679 1022 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_705 1124-0212 310 µM -1.4811002927202 0.0641640056810979 no 3132 0.069289924946071 1003 9554485
SGTC_407 eburnamonine 100 µM -1.48268938869791 0.0639588596956843 no 3133 0.0690784776028597 1004 3195
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.48359349032443 0.0638423716105232 no 3134 0.0689583987041898 1017 5377381
SGTC_342 k048-0088 23.3 µM -1.48587347364867 0.0635493421749266 no 3135 0.0686562955952613 1020 6820570
SGTC_389 tpck 16.7 µM -1.48895776543084 0.0631546078018804 no 3136 0.0682492453312822 1036 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2651 TUB2.036 5 µM -1.49475853984647 0.0624173873583836 no 3137 0.0674887351350011 990 15992207 YFL037W TUB2
SGTC_710 3448-4187 58 µM -1.496256981186 0.0622280452658068 no 3138 0.0672933504045516 1010 3946412
SGTC_2593 nobiletin 86.24 µM -1.49762173265557 0.0620559862542197 no 3139 0.0671157785286856 1004 72344 An anti-infammatory.
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.50133665165243 0.061589513561197 no 3140 0.0666342548468931 1005 688667
SGTC_2888 9058547 12.99 µM -1.50250081730661 0.0614438971772669 no 3141 0.0664839085126018 1010 16476514
SGTC_1697 st025554 27.742 µM -1.50536268208849 0.0610870719772853 no 3142 0.0661154289472492 1017 1269519
SGTC_475 α-linolenic acid 10 µM -1.51715069315472 0.0596343597202061 no 3143 0.0646143209263297 1005 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2462 5162487 171.77 µM -1.5180053309631 0.059530098819814 no 3144 0.0645065273833686 1037 2259986
SGTC_3281 9140613 49.47 µM -1.5196167502343 0.0593339036283567 no 3145 0.0643036627909159 994 16013766
SGTC_203 k066-0004 30.888 µM -1.52087628315752 0.0591809049540605 no 3146 0.0641454433314782 1056 6795412
SGTC_2424 5537928 59.2 µM -1.52468108937005 0.0587206040226075 no 3147 0.0636693303710252 1007 5382802
SGTC_1117 retinoic acid 1.10837 µM -1.52653766182499 0.0584970205727759 no 3148 0.0634380092280093 1042 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_641 4092-0595 30 µM -1.52845930399607 0.0582663054824313 no 3149 0.0631992701429738 1035 786260
SGTC_1694 st024011 44.9 µM -1.53360520572626 0.0576520005498504 no 3150 0.0625634034345952 1033 2787533
SGTC_3323 9138564 53.9225 µM -1.53620503230966 0.057343582352414 no 3151 0.0622440510938937 1015 43912313 YNL103W MET4
SGTC_767 0929-0023 86 µM -1.53665389501399 0.0572904652988693 no 3152 0.062189043525121 1025 1204563
SGTC_1149 3909-7961 23.3 µM -1.54177948340239 0.0566866604406265 no 3153 0.0615635946686577 1023 735261
SGTC_290 2043-6722 48.1 µM -1.55322083670785 0.0553569334687926 no 3154 0.0601851925043093 1027 773758 YLR208W SEC13
SGTC_835 0312-0010 67.2 µM -1.55946919492288 0.05464121091517 no 3155 0.0594426850583406 1028 1626196
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.56169161844314 0.054388413097755 no 3156 0.0591803271288438 1014 23847180
SGTC_927 2425-1185 123 µM -1.56338776648631 0.0541961016520803 no 3157 0.0589807079198931 1030 730375
SGTC_1926 methyl fluorone black 53.6 µM -1.56407119300348 0.0541187661270182 no 3158 0.0589004250964886 968 72721 Reacts with homocysteine.
SGTC_1026 k007-1105 30.6 µM -1.56499413768421 0.0540144657306767 no 3159 0.0587921419431693 1017 7066794
SGTC_789 1309-1135 70.6 µM -1.56922957374944 0.0535378654761088 no 3160 0.0582972277801029 1023 3092424
SGTC_2106 5357045 167.29 µM -1.56973891932795 0.0534807755508801 no 3161 0.0582379314270063 1032 668842
SGTC_2937 9044753 11.33 µM -1.57728720293009 0.052640369277568 no 3162 0.0573647278047994 1003 6465530 YGL099W LSG1
SGTC_1390 3413-2614 145 µM -1.5826922793474 0.0520450469669967 no 3163 0.0567458094499725 1047 3421432
SGTC_459 nigericin 15.3 µM -1.59027275579533 0.0512191482771367 no 3164 0.0558866684592311 1041 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2546 rhodinyl acetate 100 µM -1.59213553542258 0.0510178014862485 no 3165 0.0556771270355523 1010 6708682
SGTC_52 0329-0193 875 nM -1.59269883581185 0.0509570388817261 no 3166 0.0556138844258885 1026 3739292
SGTC_808 0711-0032 135 µM -1.59947333235262 0.0502307848922104 no 3167 0.0548577347324877 1028 4252555
SGTC_1881 5652484 16 µM -1.60419432661623 0.0497295706899498 no 3168 0.0543356124501631 1039 2255129
SGTC_112 phenothiazine 287.218 µM -1.60448424334521 0.0496989215844709 no 3169 0.0543036774388285 1037 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2513 baicalein 25.65 µM -1.60609472143829 0.049528941088017 no 3170 0.0541265497563944 1050 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1959 st077091 55.8 µM -1.6153343069246 0.0485626831832475 no 3171 0.0531191590399419 1019 821356 YKL052C ASK1
SGTC_1648 st011736 69.8 µM -1.61708260404223 0.0483815567184252 no 3172 0.0529302256906056 1044 2855514
SGTC_2097 5376186 200 µM -1.61863294634092 0.0482213910834436 no 3173 0.0527631309832128 1036 742755
SGTC_2915 7971052 15.16 µM -1.62018845838247 0.0480611179746335 no 3174 0.0525958999687766 1004 5741558
SGTC_2853 9015042 58.44 µM -1.62809240277045 0.0472533060735888 no 3175 0.0517526471097449 1020 6457456
SGTC_2373 9071805 200 µM -1.63496027691792 0.0465602535393827 no 3176 0.0510286875519166 1046 10149009
SGTC_2966 9084041 48.03 µM -1.63515315182444 0.0465409085017512 no 3177 0.0510084730944242 1038 17741380
SGTC_2626 ethyl orsellinate 100 µM -1.6414531645904 0.0459125662589337 no 3178 0.0503516908190763 1035 75653 A natural product.
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.64149241462953 0.0459086730638003 no 3179 0.0503476201904199 994 688669
SGTC_85 0868-0259 160.055 µM -1.65021850422223 0.045049699446108 no 3180 0.0494491267436393 1017 83173
SGTC_2949 9072542 2.23 µM -1.65270964710436 0.0448068655778733 no 3181 0.0491949850425412 1038 16457352
SGTC_3229 9132204 49.47 µM -1.65360134669527 0.0447202002579225 no 3182 0.0491042694486932 1060 17682924
SGTC_633 0437-0093 97.7 µM -1.65940546515594 0.0441593853222444 no 3183 0.048517057883955 1036 2831118
SGTC_733 4069-0007 56.1 µM -1.66118078364386 0.0439889844697792 no 3184 0.0483385718809443 1041 5717425 YNL287W SEC21
SGTC_1833 st055984 71 µM -1.66332357021173 0.0437840195145782 no 3185 0.0481238415320591 1045 676288
SGTC_530 4358-1714 28 µM -1.66497459132587 0.0436266197241249 no 3186 0.047958912574855 1029 1564641
SGTC_3061 glucosamine 200 µM -1.66656615345456 0.0434753210082345 no 3187 0.0478003518771029 1024 91431 and experimental redox chemotherapeutic
SGTC_1140 3229-1848 2.98 µM -1.66712013143185 0.04342275766195 no 3188 0.0477452599389434 1033 2849525
SGTC_2495 cafestol 54.53 µM -1.66867066871959 0.0432759100378208 no 3189 0.0475913325640474 1032 16667697 An anti-infammatory.
SGTC_1646 st011709 75.6 µM -1.66901726900466 0.0432431392682426 no 3190 0.0475569787317262 1048 5757843
SGTC_1490 4089-0339 670 nM -1.68085804633472 0.0421355884684536 no 3191 0.0463952453141093 1045 742542
SGTC_2163 5671233 125 µM -1.68137422414104 0.0420878338492671 no 3192 0.0463451244661229 1023 701023
SGTC_2024 5144227 134 µM -1.69528771719379 0.0408170358385697 no 3193 0.0450104268629185 1037 3475211
SGTC_480 am 92016 50 µM -1.69889516107809 0.0404926801386316 no 3194 0.0446694694621297 1056 2129 K+ channel blocker.
SGTC_3263 9137018 49.47 µM -1.70079248695932 0.0403229276388551 no 3195 0.0444909802826826 1031 43844957
SGTC_1870 st057514 26.5 µM -1.70789890418999 0.0396922505521396 no 3196 0.0438275512825305 1043 5393161
SGTC_1868 st057644 42.7 µM -1.71303471231548 0.0392414717589505 no 3197 0.0433530768573986 1053 688665
SGTC_3130 9127414 49.47 µM -1.71654019157367 0.0389361888382717 no 3198 0.0430316091859084 1050 1494646
SGTC_1523 st012844 44.7 µM -1.72135331584053 0.0385201801393278 no 3199 0.0425933650817393 1040 4274103
SGTC_1176 0848-0131 83.3 µM -1.72158069830308 0.0385006169390253 no 3200 0.0425727510787928 1055 6769040
SGTC_3167 9103034 49.47 µM -1.72285029261817 0.0383915342180715 no 3201 0.0424578006267275 1062 5127859
SGTC_917 harmaline 728.087 nM -1.7250690857931 0.0382015019272193 no 3202 0.0422575114755237 1021 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1355 1499-0035 1.68 µM -1.73141640862254 0.0376621073146918 no 3203 0.0416887610566604 1053 1548538
SGTC_2743 auranofin 4.32 µM -1.73387540777996 0.03745481990584 no 3204 0.0414700960848972 1041 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2686 alizarin 95.37 µM -1.73444457854972 0.0374069732831706 no 3205 0.0414196156130878 1038 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_814 3342-0569 96 µM -1.74491489499091 0.0365356706716365 no 3206 0.0404998421011343 1047 4346283
SGTC_2740 felodipine 17.08 µM -1.74623681481006 0.0364268553895381 no 3207 0.0403849050668292 1055 3333 L-type calcium channel blocker
SGTC_1213 1315-0166 115 µM -1.75708150508486 0.0355441406226684 no 3208 0.0394519588448184 1040 768401
SGTC_217 ketoconazole 989 nM -1.76843614805518 0.0346387887448985 no 3209 0.0384940089656566 1010 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_620 0109-0052 432 µM -1.77625604528964 0.0340263575271629 no 3210 0.0378453622145198 1048 493037
SGTC_2752 diclazuril 33.15 µM -1.77684746471466 0.0339804037866836 no 3211 0.0377966700131163 1038 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1655 st012546 55.1 µM -1.7825811361699 0.0335375338530229 no 3212 0.0373272563985445 1063 720985 YLR208W SEC13
SGTC_196 k015-0023 18.111 µM -1.78636822095518 0.0332476324243993 no 3213 0.037019828787262 1044 5211998
SGTC_563 tetrahydrosecaminediol 614 µM -1.79129604347486 0.0328735008819159 no 3214 0.0366229003586111 1054 334274 A psychoactive constituent of the cannabis plant.
SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.80000901890093 0.0322204868173795 no 3215 0.0359296070750495 1038 6708630 An antioxidant.
SGTC_2282 7944268 200 µM -1.8030551079104 0.0319947317902664 no 3216 0.0356897802256854 1048 2970414
SGTC_1343 1487-0095 224 µM -1.81079167792934 0.0314272173181649 no 3217 0.0350865525121163 1049 4560101 YGL055W OLE1
SGTC_1506 4226-2149 212 µM -1.8178053650971 0.0309199467546117 no 3218 0.034546943173929 1057 991114
SGTC_1243 0416-0003 5.65 µM -1.81917227171804 0.0308218774344122 no 3219 0.0344425758768543 1045 2141977
SGTC_2278 7948257 134.34 µM -1.81951126781528 0.0307975958974271 no 3220 0.0344167326684619 1046 1247028
SGTC_42 0133-0086 60.653 µM -1.84313075029345 0.0291443657181028 no 3221 0.0326549613074148 1045 162923 Model of phenazepam hydroxylation.
SGTC_1554 st069299 38.7 µM -1.84786458603325 0.0288220538909881 no 3222 0.032310967387316 1046 24207999
SGTC_2563 tomatine 8.54 µM -1.85982854339774 0.028020654315768 no 3223 0.0314548938224142 1054 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_3161 9100388 49.47 µM -1.86350661116669 0.0277780424575891 no 3224 0.031195511634501 1074 25236368
SGTC_2128 5255449 168.493 µM -1.87830370492177 0.0268196165037637 no 3225 0.0301698150103137 1042 736008
SGTC_3102 9121669 49.47 µM -1.88664167029196 0.0262918272505468 no 3226 0.0296042690134878 1077 41905072
SGTC_2032 5185112 25.99 µM -1.88984444175792 0.0260914147529803 no 3227 0.0293893839189946 1050 5718189
SGTC_2190 6049624 200 µM -1.89483298400456 0.0257818038950323 no 3228 0.0290572659440694 1052 2265554
SGTC_2456 5770359 74.46 µM -1.89701817432017 0.0256471530254226 no 3229 0.028912769732912 1050 3118787
SGTC_1446 4239-0190 62 µM -1.89953098300543 0.0254930426364546 no 3230 0.0287473484634567 1065 1340085
SGTC_2295 7971645 200 µM -1.9045564477461 0.0251871569883975 no 3231 0.028418876236855 1060 2978226 YKL099C UTP11
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.91230404651045 0.0247216124874379 no 3232 0.0279186035576322 1042 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1821 st053465 65.6 µM -1.92226963334979 0.0241334258946119 no 3233 0.0272859194561872 1071 675086
SGTC_202 3594-0513 34.79 µM -1.9343543501482 0.0234359792894336 no 3234 0.0265347875342881 1072 708429
SGTC_2426 5582046 32.21 µM -1.93570597681839 0.0233590378418784 no 3235 0.0264518610158323 1057 2251934
SGTC_2697 mebhydrolin 72.4 µM -1.94040896027458 0.0230929748366756 no 3236 0.0261650042563549 1065 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1773 st048542 73.5835 µM -1.94065355191007 0.0230792075909766 no 3237 0.026150156916398 1063 3237138
SGTC_1389 3405-0187 19 µM -1.9408053812871 0.0230706651000089 no 3238 0.0261409440280694 1045 799890
SGTC_3154 9100113 49.47 µM -1.94359612196093 0.0229141211989249 no 3239 0.0259720869271325 1054 25237525
SGTC_2335 9018011 154.17 µM -1.94911592312558 0.0226071276657025 no 3240 0.0256407912566208 1046 6458208
SGTC_515 4092-1064 102 µM -1.9682305282744 0.0215706970177967 no 3241 0.0245207595955572 1074 717353
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.97111189259045 0.0214180015300469 no 3242 0.0243555393663962 1044 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_699 0375-0592 111 µM -1.98146908445885 0.0208766553840207 no 3243 0.0237693465166254 1059 762578
SGTC_2862 9027634 71.43 µM -1.98565336387283 0.0206612614129586 no 3244 0.0235359133463212 1045 5012562
SGTC_305 1682-2595 20.8 µM -1.99178517768792 0.0203490163418639 no 3245 0.0231973166191485 1054 226033
SGTC_1861 st057647 17.4 µM -2.01531541073291 0.0191876713454385 no 3246 0.0219358056093401 1072 688668
SGTC_66 0109-0187 42.4 µM -2.01557506055279 0.0191751772489842 no 3247 0.0219222149111373 1051 759417
SGTC_105 0111-0055 734.78 µM -2.01813398083064 0.019052414008941 no 3248 0.0217886547653003 1061 5179370
SGTC_1020 4335-0961 93.3 µM -2.02054244036149 0.0189374802482129 no 3249 0.0216635762791364 1064 669075
SGTC_2131 toluylene red 5.2905 µM -2.02533753067851 0.018710409619605 no 3250 0.0214163586200139 1046 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_657 3534-0529 86.7 µM -2.02669943962934 0.0186463407634303 no 3251 0.0213465799140888 1081 1049549
SGTC_436 n,n-dimethylsphingosine 3.3 µM -2.03078764954628 0.0184551379518046 no 3252 0.0211382702104977 1059 5282309
SGTC_2275 7947463 200 µM -2.03820740697326 0.0181123848221365 no 3253 0.0207645975349175 1042 1225414
SGTC_2802 7925815 54.55 µM -2.040325865063 0.0180155248385226 no 3254 0.0206589401503722 1056 1262923
SGTC_2327 6189656 200 µM -2.04368919167871 0.0178626543126457 no 3255 0.0204921308217715 1055 5349088
SGTC_2181 6316240 54.2555 µM -2.04436879845549 0.0178318994437386 no 3256 0.0204585636478405 1067 12779990
SGTC_3072 9116419 49.47 µM -2.0489952271495 0.017623733432242 no 3257 0.0202312908180728 1058 17170162
SGTC_1013 4112-3890 241 µM -2.05183298780192 0.0174970775092322 no 3258 0.0200929481024129 1062 705171
SGTC_2524 avocatin b 10.57 µM -2.06797341511242 0.016791377905862 no 3259 0.0193212615193458 1074 6710748
SGTC_3193 9111931 49.47 µM -2.0685483504965 0.0167666959859228 no 3260 0.0192942444833122 1066 17087244
SGTC_1364 1653-0028 37.6 µM -2.07778109233893 0.0163745661262338 no 3261 0.0188647630376498 1064 5718652
SGTC_2700 st077718 96.8 µM -2.0843476556098 0.0161004756137118 no 3262 0.0185642777277677 1072 904970
SGTC_3191 9110352 49.47 µM -2.08542489535066 0.0160558887531395 no 3263 0.01851537449565 1055 17122424
SGTC_295 k015-0027 31 µM -2.08639492956836 0.0160158297109516 no 3264 0.018471431955993 1075 3887424
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -2.10632922668601 0.0152113823175848 no 3265 0.0175878821251228 1066 229346 A bile salt which induces apoptosis.
SGTC_1099 5-nonyloxytryptamine 2.85 µM -2.10849913583605 0.0151259474585174 no 3266 0.017493918714712 1058 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_292 k038-0015 474 µM -2.10994124887299 0.0150693961293888 no 3267 0.0174317083538322 1072 46368540
SGTC_731 3966-0296 387 µM -2.11361982272913 0.0149259659635467 no 3268 0.0172738757000122 1074 660956
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -2.12644088947782 0.0144352006061859 no 3269 0.0167332830799486 1075 2333 A French combination drug.
SGTC_928 2764-0428 58.7 µM -2.12861550981836 0.0143533534469031 no 3270 0.0166430421210578 1071 662578
SGTC_127 0180-0333 59.125 µM -2.12906147466198 0.0143366179380718 no 3271 0.0166245873126286 1024 771601
SGTC_2031 5180455 200 µM -2.13004503500124 0.0142997677294412 no 3272 0.016583947749062 1077 29949
SGTC_1167 k781-0610 148 µM -2.13106713189068 0.0142615601672026 no 3273 0.0165418060141161 1063 4525169
SGTC_646 4092-0839 27.3 µM -2.14232373423584 0.0138465547246873 no 3274 0.0160837201170487 1073 877796
SGTC_2657 nystatin 74.44 µM -2.14449712552998 0.0137676376265575 no 3275 0.0159965377520934 1064 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3059 1327-0034 3 µM -2.14612093090584 0.0137089298100392 no 3276 0.0159316658803623 1068 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_11 0438-0307 1.3 µM -2.16538285745144 0.0130288370744809 no 3277 0.015179188871618 1075 4011476
SGTC_1111 tnp00062 510.699 nM -2.16634287888846 0.0129957178161908 no 3278 0.0151424976974181 1071 676306
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -2.16659660226654 0.0129869769208213 no 3279 0.0151328133538228 1074 688751
SGTC_2943 9068529 45.32 µM -2.1689065507587 0.0129076315765099 no 3280 0.0150448896579499 1063 3270634
SGTC_2972 9093619 59.92 µM -2.1822029704651 0.0124590113189809 no 3281 0.014547278089146 1054 25236256
SGTC_2398 5228213 48.84 µM -2.19682446626237 0.0119813313073754 no 3282 0.0140164925064809 1072 80771 YMR134W ERG29
SGTC_1749 st037932 54.2 µM -2.1993493831289 0.011900471619377 no 3283 0.0139265444064786 1073 594497
SGTC_2544 sphondin 68.51 µM -2.20074482334895 0.0118559865042082 no 3284 0.0138770468470177 1063 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2763 lisinopril 49.32 µM -2.2041143404713 0.0117491642965857 no 3285 0.0137581519383199 1061 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2320 7373003 200 µM -2.21138155301477 0.0115216152366366 no 3286 0.0135047130881659 1052 5415828
SGTC_3356 9151811 4.48 µM -2.22014452141474 0.011252329883018 no 3287 0.0132044794269576 1078 1859254 YPR165W RHO1
SGTC_1851 st056236 18.9 µM -2.22669199109597 0.0110547135519913 no 3288 0.0129839330309341 1067 5393171
SGTC_2432 5630864 12.22 µM -2.2323231073957 0.0108871761813285 no 3289 0.0127968078638892 1072 5714970
SGTC_575 k072-0246 11.9 µM -2.2353986204767 0.0107966096579268 no 3290 0.0126955953016864 1079 6796779
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -2.2483594707162 0.0104221116621504 no 3291 0.0122766386781056 1061 6708739 YPR165W RHO1
SGTC_73 0327-0325 16.231 µM -2.25065359397732 0.0103570168382475 no 3292 0.0122037430573077 1007 53298
SGTC_2473 5854593 8.94 µM -2.26223701382573 0.0100337269737443 no 3293 0.0118413817982521 1076 2872951
SGTC_382 3229-0966 23.2 µM -2.2696077097083 0.00983262904295269 no 3294 0.0116156977166244 1074 5722370
SGTC_1782 st039423 80.636 µM -2.28505997772912 0.00942243212503966 no 3295 0.0111546555689536 1082 2068169
SGTC_816 0325-0417 81.3 µM -2.28769559617983 0.00935398151744256 no 3296 0.0110776271726029 1067 68101
SGTC_2273 7815444 169.05 µM -2.30336446758625 0.00895595135620669 no 3297 0.0106291726005375 1067 2824616
SGTC_3341 9147222 25.867 µM -2.30418372509265 0.00893555450469066 no 3298 0.010606166199255 1068 1939759
SGTC_3317 9138495 8.753 µM -2.30883582379508 0.00882050230855108 no 3299 0.0104763466474514 1081 17020139
SGTC_634 1611-4317 11.2 µM -2.3094622590276 0.00880510940321924 no 3300 0.0104589718231538 1082 2843522
SGTC_1033 k072-0102 21.3 µM -2.32433136387888 0.0084465907109889 no 3301 0.0100538705364814 1069 5965931
SGTC_727 3032-0951 202 µM -2.33764477906071 0.0081365202080867 no 3302 0.00970284148757185 1085 3652836
SGTC_3189 9110682 49.47 µM -2.34741204900807 0.00791544435558444 no 3303 0.00945216783789921 1074 17122418
SGTC_3098 9119039 49.47 µM -2.35008881664372 0.00785578725601813 no 3304 0.00938446597091607 1075 17161528
SGTC_1637 st007924 17.4 µM -2.35532092889126 0.00774032036254617 no 3305 0.00925335725421023 1063 683336
SGTC_1911 st060208 74.3 µM -2.35582391633908 0.0077292990819903 no 3306 0.00924083802234971 1076 688783
SGTC_3305 9127027 53.8275 µM -2.42584005397592 0.00632363142956197 no 3307 0.00763649989041288 1078 41905295
SGTC_558 k064-0027 21.3 µM -2.44407095899175 0.00599695911075613 no 3308 0.00726128493512346 1081 5088526
SGTC_380 3970-0968 6 µM -2.45022421628952 0.00589012784390212 no 3309 0.00713836409876004 1084 2891601
SGTC_780 0109-0199 192 µM -2.45047255007431 0.00588585199654319 no 3310 0.00713344201668091 1081 610414
SGTC_1781 st038725 66.3 µM -2.45076468186198 0.00588082555316901 no 3311 0.00712765567237078 1083 4270275 YIL048W NEO1
SGTC_913 3487-1245 167 µM -2.45520551790198 0.00580488364287662 no 3312 0.00704020319113194 1068 4016153
SGTC_827 3253-0474 693 µM -2.46471512536149 0.00564518175091948 no 3313 0.00685611112598396 1084 5402065
SGTC_1794 st048918 76.9 µM -2.46905041204963 0.0055736796677465 no 3314 0.00677360659833373 1065 672303
SGTC_2307 7538926 6.34 µM -2.51160366931343 0.00491342469204149 no 3315 0.00600919899368989 1068 96582
SGTC_110 0850-0284 111.64 µM -2.52268792034823 0.00475330768740277 no 3316 0.00582308527820125 1078 3906265
SGTC_2521 angolensin 13.4 µM -2.53635278203345 0.00456232727741877 no 3317 0.00560069144335588 1082 821428 A flavenoid.
SGTC_1060 3448-7350 82 µM -2.54701885512663 0.00441804955320124 no 3318 0.005432378131726 1083 570178
SGTC_788 1182-0090 188 µM -2.54958054398728 0.0043840110134391 no 3319 0.00539262974237818 1087 5715185
SGTC_1079 idarubicin 2.36 µM -2.56574413434254 0.00417458887033329 no 3320 0.0051477370919078 1087 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_728 3030-5151 22.5 µM -2.5777461227391 0.0040249238656724 no 3321 0.00497235161575288 1091 3125388
SGTC_537 1334-0398 209 µM -2.61127844700611 0.00363190917897646 no 3322 0.00451022074621254 1087 5846986
SGTC_723 4182-0001 115 µM -2.61148851551149 0.00362955962888754 no 3323 0.00450745078497058 1079 744821 YLR208W SEC13
SGTC_2345 9052315 157.45 µM -2.65394974903621 0.00318172729515882 no 3324 0.0039777836688167 1077 6469265
SGTC_2193 5925765 200 µM -2.6682591892001 0.00304240864342629 no 3325 0.00381227069178333 1083 877370
SGTC_1214 0358-0031 63.7 µM -2.6718733943584 0.00300810086273943 no 3326 0.00377145506413344 1084 4301366
SGTC_726 3448-4391 34.2 µM -2.67357793725683 0.00299204179849642 no 3327 0.00375234178708074 1082 1356692
SGTC_1518 st038567 90.8 µM -2.67520090760096 0.00297682309122943 no 3328 0.00373422396596847 1086 77966
SGTC_1557 sumaresinolic acid 42.3 µM -2.73953948312742 0.00242693924305621 no 3329 0.00307626621991911 1086 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2768 sulfasalazine 50.2 µM -2.79415514335555 0.00203417040183283 no 3330 0.00260177539180162 1085 5384001 An antioxidant and salicylic acid derivative.
SGTC_3066 9117245 49.47 µM -2.81711809057051 0.00188699907576369 no 3331 0.00242283527196971 1083 17176980
SGTC_2515 chrysin 20.77 µM -2.81982167989963 0.00187032390952277 no 3332 0.00240251715631486 1085 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1676 st018489 23.4 µM -2.8724619311005 0.00157122751300294 no 3333 0.00203643573405892 1082 3696235
SGTC_2171 5739187 198.077 µM -2.89926494321686 0.00143631989019032 no 3334 0.00187019341613223 1088 2262761
SGTC_2198 6589944 200 µM -2.91645804093087 0.00135543965276445 no 3335 0.00177015169089328 1087 5290268
SGTC_1463 k081-0032 34.1 µM -2.93282298895445 0.00128234270367306 no 3336 0.00167947669022382 1056 977755
SGTC_1462 k081-0014 26.5 µM -3.03839833699761 0.000891092058294315 yes 3337 0.00118919669731121 1048 3270634
SGTC_1923 st058458 19.1 µM -3.06177374498223 0.000820870576658186 yes 3338 0.00110014849083457 1090 3534982
SGTC_926 2268-1401 59.4 µM -3.08861025287258 0.000746549833337412 yes 3339 0.00100547530824291 1085 2931578
SGTC_2433 5607874 27.82 µM -3.11189891790923 0.000687132554249473 yes 3340 0.000929440681117048 1083 2252428
SGTC_108 0509-0257 621.132 µM -3.18859463617875 0.000520919258413514 yes 3341 0.000714831021895522 1092 536624
SGTC_1752 st044819 83.042 µM -3.25486594492972 0.000408133543790765 yes 3342 0.000567229504134078 1089 441209 YML126C ERG13
SGTC_2219 9098279 200 µM -3.29902977653075 0.000346042560752543 yes 3343 0.000485098097285482 1092 902349
SGTC_3050 9093513 49.47 µM -3.50479039791296 0.000156333653951268 yes 3344 0.000228483448347517 1089 25236664
SGTC_1645 Cervolide 78 µM -3.55345844138091 0.000128747926737766 yes 3345 0.000190100632167867 1094 23173 A fragrance.
SGTC_1166 k206-0078 225 µM -3.57046266149727 0.000120237217385571 yes 3346 0.000178175625240401 1094 5404595
SGTC_1739 st037196 92.5 µM -3.59344431824683 0.000109571199872388 yes 3347 0.000163167705655166 1091 612214
SGTC_1750 st081859 2.357 µM -3.72705622457002 6.31805258792498e-05 yes 3348 9.68646269355937e-05 1087 5291695
SGTC_1681 tripelennamine 100 µM -3.82965306189598 4.08953614237821e-05 yes 3349 6.41620234601001e-05 1089 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_372 0155-0182 15.9 µM -4.28012481334573 5.33935321488545e-06 yes 3350 9.33942646900858e-06 1015 771486
SGTC_1747 st037496 66.6 µM -4.42981706773867 2.59329442499117e-06 yes 3351 4.71565278634374e-06 1094 723305
SGTC_729 4092-0585 94.1 µM -4.64207806072408 8.95568466323464e-07 yes 3352 1.72461246789295e-06 1095 2169061
SGTC_722 3534-0461 190 µM -5.56418999319456 5.16598387408988e-09 yes 3353 1.3168643881929e-08 1095 658262