SGTCid condition conc unit PMT1|YDL095W.score PMT1|YDL095W.strain.pval PMT1|YDL095W.strain.significant PMT1|YDL095W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_143 4032-1194 15.74 µM 11.6883186811758 4.06229287494656e-25 yes 1 7.31266158475362e-32 3 1806963 SGTC_117 lucigenin 22.078 µM 9.15758910295655 3.90198622531864e-16 yes 2 2.65348279294011e-20 10 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_800 3448-7362 155 µM 6.35490074958877 1.14428615377825e-08 yes 3 1.04280618404005e-10 37 15991913 SGTC_1028 k015-0029 4.8 µM 4.90965707727894 7.95585368127756e-06 yes 4 4.56178976348312e-07 8 4588309 SGTC_572 0960-0087 17.7 µM 4.55179498132406 3.16084083922621e-05 yes 5 2.65950775180405e-06 17 6796365 SGTC_1163 k060-0048 49.9 µM 4.36623936736332 6.22647928128008e-05 yes 6 6.32019772144199e-06 14 6809982 SGTC_663 1486-0733 13.9 µM 4.29337962064961 8.0693835110027e-05 yes 7 8.79868718987549e-06 44 722445 YPR165W RHO1 SGTC_1614 st002383 48.6 µM 4.0973769558326 0.000158973785888834 yes 8 2.08929074490306e-05 14 1947235 SGTC_306 1672-3436 11.6 µM 3.87959772993003 0.000326723557146175 yes 9 5.23146784849471e-05 15 6797378 SGTC_2399 5884133 200 µM 3.83862287183631 0.000372701342379921 yes 10 6.1863147735501e-05 78 722445 SGTC_98 0074-0023 107.663 µM 3.80828265242254 0.000410542530640063 yes 11 6.99676335585339e-05 43 3563821 SGTC_531 3788-1495 174 µM 3.79404280624473 0.000429505385557666 yes 12 7.41070525014863e-05 20 2896655 SGTC_830 4076-0286 57.8 µM 3.73595825466865 0.000515579590370123 yes 13 9.35008459595565e-05 71 6866659 SGTC_3211 9128781 49.47 µM 3.71280206355109 0.000554144859108216 yes 14 0.000102488597233344 73 17194361 SGTC_2007 4011539 71.82 µM 3.70096050641606 0.000574881203117841 yes 15 0.000107392453504253 72 45595301 SGTC_906 1165-0455 526 µM 3.63253533258261 0.000709422387405037 yes 16 0.000140325066485632 18 3252859 SGTC_2784 7567673 72.73 µM 3.58856170184267 0.00081062038316994 yes 17 0.000166253652339642 42 3471247 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 3.55183526042914 0.0009051474422991 yes 18 0.000191277146336805 19 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 3.53536238141218 0.000950751256150768 yes 19 0.000203608146639755 40 1377 SGTC_625 k213-0058 121 µM 3.52717565806546 0.00097419197520712 yes 20 0.000210009004802944 141 3655420 SGTC_2604 4'-hydroxychalcone 11.32 µM 3.51212587189775 0.00101867269720666 no 21 0.000222268702141241 56 5282362 SGTC_2364 9055074 200 µM 3.47499940230548 0.0011364864259419 no 22 0.00025542724464499 31 6470630 SGTC_301 4119-0100 24.5 µM 3.43950052274968 0.00126068274270211 no 23 0.000291394329561321 103 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_421 streptovitacin 30 mM 3.42635557157639 0.00130973708702208 no 24 0.00030586949780479 45 91467 include heat shock SGTC_2289 7946404 165.07 µM 3.40580192431678 0.00138994546746471 no 25 0.000329850116363828 116 1246120 YPR165W RHO1 SGTC_814 3342-0569 96 µM 3.37000804447662 0.00154040947722716 no 26 0.000375829946484132 40 4346283 SGTC_2359 9039622 200 µM 3.34356664433008 0.00166093956521597 no 27 0.000413544127109315 38 6463596 SGTC_453 enantio-paf c16 10 µM 3.3247386087094 0.00175193423817274 no 28 0.000442507334493184 206 13871343 A lipid and platelet activating factor SGTC_2368 9071271 200 µM 3.32253632599396 0.00176286890233225 no 29 0.000446015278767978 64 27209959 SGTC_573 3702-0553 84.7 µM 3.31844401176044 0.00178335290545398 no 30 0.00045260233731635 28 1222756 SGTC_931 2812-0076 566 µM 3.23132950347664 0.00227406325349294 no 31 0.000616079041656427 55 3450959 SGTC_129 0088-0017 176.636 µM 3.22097258400584 0.00233989171793955 no 32 0.000638781843800022 99 182446 SGTC_2404 5161160 200 µM 3.16929427898535 0.00269485876737892 no 33 0.000764047955305396 48 2831543 SGTC_2786 7743617 45.45 µM 3.12222158564838 0.00305976034545345 no 34 0.000897458933101458 60 583674 SGTC_922 1866-0035 480 µM 3.10943997378471 0.00316624073206763 no 35 0.000937211835876936 115 3156169 SGTC_3078 9116413 49.47 µM 3.06270561403035 0.00358454406583002 no 36 0.00109672863587381 75 17177322 SGTC_2940 9060638 45.86 µM 3.00389031710171 0.00418113319269436 no 37 0.00133275699996302 78 4027022 SGTC_783 0848-0141 92.7 µM 2.99318170497823 0.00429885013989215 no 38 0.00138042661113001 44 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1477 0139-0234 16 µM 2.92762336426474 0.00508630305587809 no 39 0.00170781764169687 43 620880 SGTC_2997 9067075 71.4286 µM 2.89512908217744 0.00552228703465982 no 40 0.0018950132302142 112 27209819 SGTC_1549 4'-methoxyflavonol 74.6 µM 2.87899598033845 0.00575084073240105 no 41 0.00199471709480377 46 97141 SGTC_1550 gossypolone 36.6 µM 2.87521619809029 0.00580558685546827 no 42 0.00201875465837162 68 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1179 1021-1431 9.29 µM 2.86962837326794 0.00588736771112052 no 43 0.0020547723905376 103 2840958 SGTC_1495 4469-0029 237 µM 2.84520231360337 0.00625697439122687 no 44 0.00221916116656062 197 793680 SGTC_1056 3448-1962 115 µM 2.84426305587699 0.00627158833894205 no 45 0.00222571401357719 69 715507 SGTC_95 0471-0001 561.058 µM 2.84388891306816 0.00627741805333921 no 46 0.00222832914661665 80 4015405 SGTC_2367 9070478 135.38 µM 2.83322236777765 0.00644564990605149 no 47 0.00230406588627473 94 572802 SGTC_708 3448-5400 146 µM 2.82972844578389 0.00650161658631598 no 48 0.00232937637062672 112 3462195 SGTC_3077 9117319 49.47 µM 2.82657276952581 0.00655253413699148 no 49 0.00235245263418709 53 17154678 SGTC_2485 5633444 17.78 µM 2.82104219963394 0.00664262219309398 no 50 0.00239339527749521 107 5724239 SGTC_2930 9013230 14.89 µM 2.81666878627912 0.00671463467030294 no 51 0.00242622692550407 112 2995857 SGTC_1264 0783-0040 158 µM 2.81421255670823 0.0067553806796508 no 52 0.00244484425572159 84 2855798 SGTC_1249 0481-0015 10.2 µM 2.76667580819854 0.00758815342581291 no 53 0.00283155202142256 77 4227577 SGTC_2904 7225135 42.03 µM 2.75087063503798 0.00788440199135839 no 54 0.00297185553219207 41 4446116 SGTC_1940 st075990 51.1 µM 2.74516760610475 0.00799376949191956 no 55 0.00302400002152952 98 1084979 SGTC_2304 7443016 91.4 µM 2.73919389197818 0.00810975606977971 no 56 0.00307950194487815 70 939854 SGTC_1910 st062352 60.4 µM 2.73094809581569 0.00827228645601762 no 57 0.00315762083894997 115 2245730 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 2.7272143296338 0.00834681782653507 no 58 0.00319357683226738 111 91467 include heat shock SGTC_257 daunorubicin 18.5 µM 2.707592758052 0.00874826260202771 no 59 0.00338865643601045 62 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2528 xanthyletin 44.79 µM 2.68361635753698 0.00926170682708234 no 60 0.00364153133613199 84 65188 An natural product with antifungal activity of unknown mechanism. SGTC_390 dec-rvkr-cmk 16.7 µM 2.67578499330292 0.00943503214823723 no 61 0.00372772282293745 119 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_755 1995-0008 37.3 µM 2.648680058327 0.0100570124051951 no 62 0.00404033953615609 83 689533 SGTC_302 1094-0063 18.9 µM 2.63012775573791 0.0105030935206135 no 63 0.0042676393078677 62 5440289 SGTC_2149 5554786 194.827 µM 2.63002494522179 0.0105056128300318 no 64 0.00426893015450289 129 745063 YPR165W RHO1 SGTC_2122 5258151 111.688 µM 2.60581142927094 0.0111138113625731 no 65 0.00458284535955811 101 2173356 SGTC_1986 st071812 45 µM 2.59472596286599 0.0114023272665699 no 66 0.00473331818668052 59 11838594 SGTC_461 N-acetylfarnesylcysteine 136 µM 2.59250826892949 0.0114608208462144 no 67 0.00476394454239318 31 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1874 staurosporine 7.6 µM 2.5613848822657 0.0123096381929458 no 68 0.0052127893009849 134 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1336 1486-0901 104 µM 2.55837376625851 0.0123945781208258 no 69 0.0052581496585747 100 5006114 SGTC_1822 st052468 42 µM 2.55174906609386 0.0125832416650973 no 70 0.00535918420956732 75 2873678 SGTC_2234 tolnaftate 200 µM 2.53370206917454 0.0131098589339698 no 71 0.00564323229873918 27 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2300 7976697 71.57 µM 2.5165471261834 0.0136279968291994 no 72 0.00592555250349515 121 2236109 SGTC_693 4161-2696 114 µM 2.51534179637669 0.0136650573339152 no 73 0.00594585171473907 60 805759 SGTC_1527 coumarin 137 µM 2.51088628399307 0.0138028076469666 no 74 0.00602142418906451 112 323 A hepatotoxic, DNA x-linker. SGTC_272 doxorubicin 8.13 µM 2.50705944933914 0.0139220756926383 no 75 0.00608701171695522 140 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1539 benzyladenosine 56 µM 2.50629442729717 0.0139460248299747 no 76 0.00610019898214446 84 92208 A nucleotide analog. SGTC_1728 st035614 33.7865 µM 2.50569486389226 0.0139648190762962 no 77 0.00611055179955108 182 15945546 SGTC_1037 k284-1091 78.7 µM 2.50439072652325 0.0140057747012776 no 78 0.00613312445457486 93 3334711 SGTC_2294 7971431 200 µM 2.4883913283371 0.0145167126099271 no 79 0.00641612238229821 100 5741572 SGTC_121 0557-0495 61.343 µM 2.48317565922289 0.0146867051672756 no 80 0.00651084285987105 209 3104427 SGTC_3051 9093778 49.47 µM 2.47755217782789 0.0148719053218365 no 81 0.0066143532388642 54 17217378 SGTC_1016 4226-1401 38 µM 2.47026370617659 0.0151149243787652 no 82 0.00675067414362894 123 2901613 SGTC_2618 avocadyne 43.43 µM 2.46390797596215 0.0153296205991362 no 83 0.00687156955892036 110 3015189 SGTC_1777 st045864 34.765 µM 2.46328006423554 0.0153509728785664 no 84 0.00688361653157035 93 4691462 SGTC_2153 5569715 200 µM 2.46274650422257 0.0153691367727045 no 85 0.00689386794776458 85 2054701 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 2.44437537394215 0.0160058973979968 no 86 0.00725516017384111 129 5106787 A p450 inhibitor. SGTC_2301 7769476 200 µM 2.44032953557866 0.0161491292374674 no 87 0.00733693473146461 98 977820 SGTC_2240 6690706 185.951 µM 2.41985537550201 0.016890916815645 no 88 0.00776334048088979 95 805876 SGTC_78 0336-0123 156.75 µM 2.418064281246 0.016957173257829 no 89 0.00780166005419071 105 6765896 SGTC_1588 farnesol 29.9 µM 2.39514060349906 0.0178249813749939 no 90 0.00830699645104494 120 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1992 st073643 23.3 µM 2.39069024511987 0.0179977761697962 no 91 0.00840836705623775 93 3161292 SGTC_724 3910-0327 137 µM 2.38922132757288 0.0180551226873864 no 92 0.008442063712307 127 2885483 SGTC_647 0140-0236 81 µM 2.37846779750707 0.01847970348279 no 93 0.00869237766426083 130 990837 SGTC_2690 usnic acid 100 µM 2.3754590823587 0.0186000077780617 no 94 0.00876356778313228 159 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 2.37331073460594 0.0186863175058087 no 95 0.0088147127889902 40 279621 SGTC_680 0417-1641 114 µM 2.37280747572624 0.0187065851053666 no 96 0.00882673146130213 124 2835990 SGTC_991 3996-0057 64.7 µM 2.35337208458638 0.0195037396177228 no 97 0.00930200377351909 129 715343 SGTC_1578 josamycin 24.2 µM 2.35178412704657 0.0195701271122542 no 98 0.00934180723874775 118 5282165 A P450 substrate. SGTC_47 0149-0135 24.25 µM 2.35101078751596 0.019602527422771 no 99 0.00936124552750534 136 5239155 SGTC_55 0767-0285 6.563 µM 2.34585553292697 0.0198196811744985 no 100 0.00949173193897775 168 3116166 SGTC_1613 st002381 52.1 µM 2.33522780365458 0.0202737993359619 no 101 0.00976576170196819 132 551167 SGTC_226 1,3-diallylurea 8.28947 mM 2.33234383882532 0.0203985408357902 no 102 0.00984130501552503 114 74537 YKL182W FAS1 SGTC_1465 k213-0056 144 µM 2.31969337437584 0.0209534291285956 no 103 0.0101787352596247 138 24048857 YMR208W ERG12 SGTC_1437 4092-1038 11.6 µM 2.31953861036257 0.0209602958809936 no 104 0.0101829250627953 130 3977136 SGTC_3023 9089636 49.47 µM 2.31598236295308 0.0211186091439804 no 105 0.0102796158478077 92 17249241 SGTC_2105 5350118 200 µM 2.3152309593724 0.021152188474954 no 106 0.0103001479036259 135 2133313 SGTC_591 4299-0174 154 µM 2.30693681725737 0.0215258542236052 no 107 0.01052917133434 107 5509088 SGTC_585 0kpi-0023 191 µM 2.30626899240669 0.0215561821170513 no 108 0.0105478033059034 132 64601 SGTC_640 3381-0960 37.1 µM 2.30343429852158 0.0216853161751565 no 109 0.0106272099139945 124 1745025 SGTC_805 3852-0218 479 µM 2.29784507899273 0.0219418476152596 no 110 0.0107853040262901 207 6615355 SGTC_641 4092-0595 30 µM 2.29677780130419 0.0219911232762722 no 111 0.0108157242673874 145 786260 SGTC_962 1254-0300 21.5 µM 2.29316522789529 0.0221586077837761 no 112 0.0109192471124554 130 7340576 SGTC_3325 9138760 55.175 µM 2.29023057181477 0.0222954542281208 no 113 0.0110039770427169 153 43844959 SGTC_642 0335-0876 158 µM 2.28552896435776 0.0225161815732992 no 114 0.011140915032167 169 6812350 SGTC_1931 st074438 57.1 µM 2.27621845956028 0.0229587237205951 no 115 0.0114164688044082 133 2787313 SGTC_787 4152-0075 138 µM 2.27320506592013 0.0231035149979502 no 116 0.0115069125826026 139 9566539 SGTC_1046 2001-0062 216 µM 2.27098247243422 0.0232108009730262 no 117 0.0115740195118072 145 739778 SGTC_2009 4012297 12.05 µM 2.26559705297673 0.0234724989574907 no 118 0.0117380328463012 188 45595307 SGTC_447 ml7 120 µM 2.2625105867414 0.0236235979937698 no 119 0.0118329377481623 159 4216 Selective myosin light chain kinase inhibitor. SGTC_616 4092-0450 108 µM 2.26231808166311 0.0236330491874852 no 120 0.0118388790287512 161 787165 SGTC_1154 4088-0362 150 µM 2.24829936904552 0.0243299079520159 no 121 0.0122785534653499 203 6618304 SGTC_1816 st051957 91.6 µM 2.2464816162229 0.0244215180610774 no 122 0.0123365878872554 128 674121 SGTC_1785 bathophenanthroline 24 µM 2.24151422900884 0.0246733397011127 no 123 0.0124963924437803 216 72812 An iron chelator. SGTC_339 3091-4833 71.4 µM 2.23872226318701 0.0248158322740932 no 124 0.0125869965120745 133 3240077 SGTC_868 0527-0199 213 µM 2.23522423861805 0.0249953331991681 no 125 0.0127013154821983 162 2849450 SGTC_137 0438-0332 85.389 µM 2.22620555782294 0.0254631534048484 no 126 0.0130002079329606 313 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 2.22494358939001 0.0255291958377156 no 127 0.0130425126530995 150 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1121 fusaric acid 630.51 nM 2.21166347365581 0.0262329197206409 no 128 0.0134949630501627 179 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_3141 9094609 49.47 µM 2.21133651847751 0.0262504478767937 no 129 0.013506271140854 189 25236309 YDL196W YDL196W SGTC_521 r062-0005 13.8 µM 2.20631283152954 0.0265210024163513 no 130 0.0136810517836838 155 2832033 SGTC_2326 6164455 177.58 µM 2.19422615780973 0.0271814975397607 no 131 0.0141095774791585 156 2888790 SGTC_2394 5221648 200 µM 2.1888481436304 0.0274797690628013 no 132 0.0143039395922556 199 788586 SGTC_677 0929-0063 136 µM 2.18618951281015 0.0276282251427272 no 133 0.014400871602722 111 1539583 SGTC_1288 0973-0013 65.5 µM 2.18406620498228 0.0277472687531935 no 134 0.0144786917798648 167 4315430 SGTC_1763 st044482 94.5 µM 2.17999624438972 0.0279766466938765 no 135 0.0146288699704059 182 88505 SGTC_119 0121-0043 24.815 µM 2.16502780981269 0.0288338755314975 no 136 0.0151927778138641 359 1092378 SGTC_688 0527-0193 473 µM 2.16370684516647 0.028910563410525 no 137 0.0152434276660223 133 4007154 SGTC_2903 5923464 63.88 µM 2.15540903221783 0.0293961747363697 no 138 0.0155649200939654 125 2876576 SGTC_1013 4112-3890 241 µM 2.15032340617072 0.0296971335726036 no 139 0.015764821109626 192 705171 SGTC_1733 st037357 54.9 µM 2.14290410240808 0.0301407776227416 no 140 0.0160603997524123 218 1272339 YGL099W LSG1 SGTC_681 1642-0006 26.6 µM 2.1422896185245 0.0301777663288481 no 141 0.0160850918577807 108 4446530 SGTC_2314 7727897 200 µM 2.14067233372384 0.0302752982645351 no 142 0.0161502355477611 164 900724 SGTC_518 1021-0119 62.6 µM 2.13049212434392 0.0308952403312915 no 143 0.0165655026660435 226 1097762 SGTC_2227 7312221 64.1025 µM 2.10550027308494 0.032461823796793 no 144 0.0176238917867888 94 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_555 4296-0685 37 µM 2.10115644376323 0.0327406855120631 no 145 0.0178136177320074 179 2908540 YHR072W ERG7 SGTC_2607 solasodine 47.35 µM 2.09988164295403 0.0328228980480826 no 146 0.0178696269782957 235 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2013 4024628 200 µM 2.09094346808509 0.0334041168881283 no 147 0.0182665659554267 221 5230760 SGTC_662 k832-1615 104 µM 2.07610759741713 0.0343875326195546 no 148 0.0189420003324604 198 5878478 SGTC_1380 2291-0730 164 µM 2.07560247470778 0.0344214297480563 no 149 0.0189653661887809 194 2999191 SGTC_285 1486-1325 46 µM 2.0750440647581 0.0344589347562146 no 150 0.0189912255207987 200 22310230 SGTC_1963 st076565 50.3 µM 2.07295519481261 0.0345995292985039 no 151 0.0190882247796379 161 4914280 SGTC_1405 3909-7894 12 µM 2.06202200538495 0.0353431107443926 no 152 0.0196028204897332 181 7104060 SGTC_3002 9075603 71.4286 µM 2.05526396259787 0.0358092538568516 no 153 0.0199267580426806 216 20105405 SGTC_1564 D-Arginine 115 µM 2.05224436202944 0.0360191561853893 no 154 0.0200729600751546 218 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1302 1159-0335 255 µM 2.04936266497744 0.0362204110897874 no 155 0.0202133325893063 173 649284 SGTC_303 1348-1668 34.2 µM 2.04741617456407 0.0363568723247153 no 156 0.0203086198004404 157 5380509 SGTC_139 0099-0334 718.624 µM 2.04706028299097 0.036381868010204 no 157 0.0203260829935564 253 97690 SGTC_353 1988-1175 58.3 µM 2.04677608418301 0.0364018385253582 no 158 0.0203400374438334 188 2788357 SGTC_448 monastrol 171 µM 2.03989617473094 0.0368880301545468 no 159 0.0206803339211735 182 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_79 0052-0007 94.094 µM 2.03643985206622 0.0371342789868795 no 160 0.0208531035532392 212 2801472 SGTC_1160 4092-0570 10.5 µM 2.01865551297092 0.0384226634572338 no 161 0.0217615184269705 249 4994975 SGTC_1198 1612-1005 86.7 µM 2.01628252148354 0.0385972974637118 no 162 0.0218852207722408 189 6998509 SGTC_777 1315-0167 517 µM 2.01408453282578 0.0387596290680948 no 163 0.0220003295682739 206 4221767 SGTC_1147 3809-1045 12.3 µM 2.01164065149012 0.0389407734890988 no 164 0.0221289154581217 229 325925 SGTC_2990 9074105 71.4286 µM 2.00484899820169 0.0394478041541799 no 165 0.0224895962512046 179 6502001 SGTC_1802 st050112 57.9 µM 2.00140795726822 0.0397067374630814 no 166 0.0226742219277812 203 4662563 SGTC_1905 st060207 84.5 µM 1.99755068612399 0.0399986325222348 no 167 0.0228826970677502 182 1948547 SGTC_1774 st048371 48.465 µM 1.98785624299299 0.0407399531528496 no 168 0.0234137956610723 255 4242727 SGTC_2589 lobaric acid 100 µM 1.98591237982126 0.0408899313458096 no 169 0.0235215269320951 237 73157 A novel microtubule depolymerizer. SGTC_254 nsc-64875 3.808 µM 1.9835124191132 0.0410757171443222 no 170 0.023655110620706 193 56993 SGTC_2425 5628681 7.85 µM 1.97913014453729 0.0414167236999133 no 171 0.0239006776581895 246 5714958 SGTC_917 harmaline 728.087 nM 1.97159170442632 0.0420086923100235 no 172 0.0243281174775856 244 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2028 5153890 36.43 µM 1.95794107309551 0.043098049686262 no 173 0.025118463809328 232 2830968 YPR165W RHO1 SGTC_158 k038-0087 26.446 µM 1.95635453687179 0.0432261265535115 no 174 0.02521170190981 391 X158 SGTC_2945 9067681 61.76 µM 1.95365249642823 0.0434449625275184 no 175 0.0253711638758951 189 16456930 SGTC_1431 4049-0260 9.09 µM 1.9492573946038 0.0438028278167781 no 176 0.0256323469260063 210 3854841 SGTC_527 4476-4215 268 µM 1.94833217661274 0.0438784646214177 no 177 0.0256876147217884 258 4418754 SGTC_2272 7805186 180 µM 1.94746986162209 0.043949053903386 no 178 0.0257392147895414 193 2956062 YPR165W RHO1 SGTC_288 1315-0019 35.1 µM 1.94714380324167 0.0439757689599475 no 179 0.0257587483879007 246 6811474 SGTC_1316 1272-0050 65.9 µM 1.94548950146884 0.0441115132967039 no 180 0.0258580460312737 193 7340392 SGTC_331 k048-0133 24.5 µM 1.94345714007464 0.0442787416916147 no 181 0.0259804745503807 188 6813582 SGTC_1241 0364-0022 50.8 µM 1.93541436030818 0.0449455424701541 no 182 0.0264697342538516 261 4563895 SGTC_660 4031-1742 102 µM 1.93445787358117 0.0450253766758254 no 183 0.0265284283764209 283 6738706 SGTC_2178 5812956 200 µM 1.93153750592043 0.045269834759718 no 184 0.0267083078802356 220 5403383 SGTC_2755 lomerizine 42.69 µM 1.92185670156065 0.0460878402608209 no 185 0.0273118956499986 256 3949 A calcium channel blocker. SGTC_1838 st055369 84.5 µM 1.9173757933774 0.0464704652939588 no 186 0.0275951036099454 218 676036 SGTC_2654 protoveratrine a 100 µM 1.91363557597333 0.0467917914147854 no 187 0.0278333680207448 215 5702278 A heart drug and vasodilator. SGTC_1025 k007-0731 70 µM 1.9098556866034 0.0471183341423869 no 188 0.0280758984996809 234 6256118 SGTC_1014 4130-3005 69.3 µM 1.90722032294058 0.0473470808928435 no 189 0.0282460314237085 278 743608 SGTC_2596 sinensetin 100 µM 1.90364304763886 0.0476590074595865 no 190 0.0284783441951617 247 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_433 pimozide 108 µM 1.90281631765645 0.0477313292012744 no 191 0.0285322586202082 177 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_845 0330-0138 4.51 µM 1.90255163822008 0.0477545017302149 no 192 0.0285495373755884 240 9039800 SGTC_2051 5263410 176 µM 1.89216266466949 0.0486711881708841 no 193 0.0292346555673695 252 227584 SGTC_1850 st056238 17 µM 1.88793518035074 0.0490482099641058 no 194 0.0295173264576177 269 5393177 SGTC_3255 9139072 49.47 µM 1.88366604490194 0.0494313102813726 no 195 0.0298050810616017 239 17646060 SGTC_719 2810-4230 27.3 µM 1.8828902999214 0.0495011792485223 no 196 0.0298576180270789 180 721079 SGTC_752 1896-0090 130 µM 1.87488870994033 0.0502264663993811 no 197 0.0304040177927463 253 772567 SGTC_1605 st000082 49.1 µM 1.87427694705816 0.0502822651024303 no 198 0.0304461316094907 237 1114022 SGTC_2565 isoliquiritigenin 100 µM 1.86550316113935 0.0510879669851595 no 199 0.031055454758231 230 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_3288 9119690 36.221 µM 1.86511206251942 0.0511241196217463 no 200 0.0310828490590451 233 17595618 YKL019W RAM2 SGTC_2529 gangaleoidin 93.61 µM 1.8565082606745 0.0519246059112324 no 201 0.0316905733396199 224 4565183 SGTC_1148 3909-7663 27.7 µM 1.85621658803834 0.0519519162954105 no 202 0.031711346313611 256 4084526 SGTC_399 oxolinic acid 75 µM 1.8481132827183 0.0527152319853738 no 203 0.0322929783246448 228 4628 A DNA gyrase inhibitor. SGTC_2202 7226349 200 µM 1.84701024075744 0.0528198210250202 no 204 0.0323728280486664 203 844334 SGTC_2413 inermin 26.06 µM 1.83698254940715 0.053778201427866 no 205 0.0331062357914071 316 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2286 7945697 125 µM 1.83439400243543 0.0540278206654794 no 206 0.0332977646294755 312 1245733 SGTC_703 3875-0075 71.8 µM 1.83030195699813 0.0544242954564863 no 207 0.0336023994602596 219 2850814 SGTC_1331 1472-0049 76.2 µM 1.83004664853741 0.05444910814749 no 208 0.0336214818317052 291 24051409 SGTC_94 0334-0113 514.748 µM 1.82765537355201 0.0546819438507905 no 209 0.0338006448278546 290 6795178 SGTC_870 0573-2213 57.6 µM 1.82308010253508 0.0551296261088654 no 210 0.0341456298582212 235 3916321 SGTC_1485 3909-9022 254 µM 1.81926831873672 0.0555048092241211 no 211 0.0344352521591959 263 714516 SGTC_678 1218-2179 85.9 µM 1.81533873351822 0.0558936943731474 no 212 0.0347359350084128 189 6820081 YOR116C RPO31 SGTC_2780 5215298 71.43 µM 1.8122553137576 0.0562003425639399 no 213 0.0349733778967377 319 2834131 SGTC_270 tamoxifen 5.46 µM 1.80597876497047 0.0568286467985097 no 214 0.0354608282855995 308 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2774 tamoxifen 10.92 µM 1.80493656023063 0.0569335086115465 no 215 0.0355423049435512 266 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1670 st016595 4.04 µM 1.80308331739333 0.0571203496051299 no 216 0.0356875653630862 274 597879 SGTC_173 1273-0061 2.693 µM 1.80201169412371 0.0572286089945777 no 217 0.0357717828574683 408 2847414 YPL266W DIM1 SGTC_1502 4534-4282 27.7 µM 1.79864840339004 0.0575694301494627 no 218 0.0360371577565085 234 3278949 SGTC_554 4483-2211 187 µM 1.79412712018646 0.0580301103542042 no 219 0.0363964406187777 286 747107 SGTC_3036 9090181 49.47 µM 1.79179903650264 0.0582684495612238 no 220 0.036582581613308 219 25236586 SGTC_3350 9150499 3.57 µM 1.79099459774136 0.0583509830722701 no 221 0.0366470809597761 354 4910996 YPR165W RHO1 SGTC_233 rapamycin 362 pM 1.78844072719462 0.0586136127090101 no 222 0.0368524652393022 272 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.78123397686902 0.0593597311536243 no 223 0.0374371176033035 233 364106 SGTC_904 1141-0088 396 µM 1.78120076241027 0.059363187020739 no 224 0.0374398295835701 279 1378119 SGTC_124 0136-0217 7.121 µM 1.78027467858656 0.0594596068560685 no 225 0.0375155095047073 344 3976905 SGTC_576 1073-0113 22.7 µM 1.77983840507238 0.0595050722815843 no 226 0.0375512052038989 442 5439563 SGTC_849 0386-0493 241 µM 1.77501546822119 0.0600095030856541 no 227 0.0379476665817678 274 726119 SGTC_2145 5634607 200 µM 1.7686288259089 0.060682627650809 no 228 0.0384779184898211 233 308662 SGTC_2775 cyproheptadine 69.59 µM 1.75810747825128 0.0618043931907414 no 229 0.0393646117976293 277 2913 A selective serotonin reuptake inhibitor. SGTC_1182 1222-0449 220 µM 1.75756223356627 0.0618629643535029 no 230 0.0394110120296467 275 658318 SGTC_1168 k815-0004 80.5 µM 1.75399357175088 0.0622473867714899 no 231 0.0397158043150476 275 642433 SGTC_3316 9136639 10.545 µM 1.74665329266503 0.0630439497506564 no 232 0.0403487484630307 281 4903665 SGTC_3302 9125395 16.351 µM 1.74530201950569 0.0631914507102236 no 233 0.0404661553000749 291 17599668 SGTC_2597 laccaic acid a 100 µM 1.74513478520062 0.0632097241809144 no 234 0.0404807049027646 353 5491415 A textile dye. SGTC_867 0518-0118 155 µM 1.74493301629263 0.0632317766784202 no 235 0.0404982647139483 301 6848158 SGTC_122 0236-0016 402.397 µM 1.73964653022154 0.0638117047339583 no 236 0.0409605517810534 379 6808838 SGTC_2313 7726885 200 µM 1.73747600546138 0.0640510061454262 no 237 0.041151592857541 313 726423 SGTC_2280 7785178 200 µM 1.71660805619046 0.0663874471937187 no 238 0.0430254047599794 270 2954328 SGTC_667 1498-1044 59 µM 1.70755945547618 0.0674208422795267 no 239 0.0438590584441141 324 6739982 SGTC_860 0443-0016 25.1 µM 1.70383593111896 0.067849680558406 no 240 0.0442058715953984 318 5337942 SGTC_525 k781-2675 26.7 µM 1.69911728602876 0.0683961495608132 no 241 0.0446485435028041 368 3651118 YDL195W SEC31 SGTC_1314 1222-0010 41.1 µM 1.69668496917717 0.0686791608199026 no 242 0.0448781179419178 304 3526027 SGTC_2993 9054257 71.4286 µM 1.6939815275253 0.0689947774657619 no 243 0.0451343966490953 374 6470217 YGL055W OLE1 SGTC_3156 9099931 49.47 µM 1.69236374714898 0.0691841811948708 no 244 0.0452883200729605 310 18111053 SGTC_993 3909-8757 62.7 µM 1.69207215332065 0.0692183624912065 no 245 0.045316108579821 274 4288324 YLR208W SEC13 SGTC_1097 itavastatin 7.23 µM 1.68821175530238 0.0696721144441545 no 246 0.045685293728983 351 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2961 9083290 32.55 µM 1.68706900526843 0.0698068718238745 no 247 0.0457950420208187 287 17741490 SGTC_1350 1495-0454 146 µM 1.67392627053367 0.071371167497678 no 248 0.0470725452278952 393 1069057 SGTC_949 1165-0505 146 µM 1.67251049125293 0.0715412713550877 no 249 0.0472118504166595 373 6244267 SGTC_3115 9123671 49.47 µM 1.67173428150528 0.0716346637869825 no 250 0.0472883654818001 285 3286988 SGTC_2095 5432005 200 µM 1.67134597170263 0.0716814197462451 no 251 0.0473266804932057 298 783734 SGTC_1784 st039334 36.3 µM 1.6641565339456 0.0725513273557841 no 252 0.0480405758785011 344 3496984 SGTC_157 1348-1695 65.819 µM 1.65786800909749 0.0733188360694174 no 253 0.0486720552534517 438 5380510 SGTC_260 nsc-65238 3.989 µM 1.65510565999806 0.0736579351704011 no 254 0.0489515334901513 303 3246252 SGTC_812 4251-0442 148 µM 1.64955532242241 0.0743429039026515 no 255 0.0495169596380405 314 5723007 SGTC_2762 leflunomide 42.06 µM 1.64373520845539 0.0750663788294287 no 256 0.0501154549486475 388 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_802 4112-3352 742 µM 1.63194350792419 0.0765485999827531 no 257 0.0513456937179717 394 704594 SGTC_2838 9002687 71.43 µM 1.62961818910886 0.0768435036838227 no 258 0.0515911088483138 334 6457060 SGTC_1915 st067105 30.6 µM 1.62901420371172 0.0769202440002944 no 259 0.0516550060698321 386 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1155 4088-0394 48.2 µM 1.62836597430382 0.077002670608198 no 260 0.0517236539635954 365 2326248 SGTC_2228 7354201 200 µM 1.62591547618872 0.0773148741191851 no 261 0.0519838186928155 298 753451 SGTC_3092 9117248 49.47 µM 1.62107510484832 0.0779343814464686 no 262 0.0525007661837606 292 17141857 SGTC_847 0342-0274 5.54 µM 1.62008816102922 0.0780611590327902 no 263 0.0526066701002933 353 18097 SGTC_597 k018-0003 82.8 µM 1.61901393203491 0.0781993265698325 no 264 0.0527221327637182 353 6786234 SGTC_656 4090-1979 187 µM 1.61730139133443 0.0784199773251886 no 265 0.0529066195592689 393 22330961 SGTC_872 0588-0139 234 µM 1.61400561644531 0.0788459463439165 no 266 0.0532631040247419 393 2047100 SGTC_1443 4112-3303 14 µM 1.61020825658966 0.0793389145447749 no 267 0.0536761997595417 376 704433 SGTC_2931 9014674 55.67 µM 1.61018173126776 0.0793423662134713 no 268 0.0536790942159608 368 2996810 SGTC_2210 7115885 190.385 µM 1.60032530752753 0.0806328404836206 no 269 0.0547632177066408 356 2927039 SGTC_1709 st033179 39.1045 µM 1.59956746957871 0.0807327145911213 no 270 0.0548472849383287 396 573381 SGTC_3191 9110352 49.47 µM 1.59929143054784 0.0807691164817906 no 271 0.0548779313769573 315 17122424 SGTC_2124 5246320 200 µM 1.59801622943106 0.0809374410207965 no 272 0.0550196826214326 368 579342 SGTC_1446 4239-0190 62 µM 1.59622002233136 0.0811749865309123 no 273 0.0552198394245814 422 1340085 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.59578007421998 0.0812332490876776 no 274 0.0552689517580216 417 6708784 An antioxidant flavonoid SGTC_3020 9089140 49.47 µM 1.59367731014789 0.0815121550628047 no 275 0.0555041643926673 381 17217859 SGTC_1864 st057645 30.4 µM 1.59214493554873 0.0817158602790738 no 276 0.0556760712033105 313 688666 SGTC_1109 tnp00067 928.257 nM 1.58936992858752 0.0820857304001323 no 277 0.0559884497955189 341 676295 SGTC_2512 diallyl trisulfide 49.23 µM 1.58146233119886 0.0831466208788328 no 278 0.056886182644812 306 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_944 3370-0224 231 µM 1.57979717859875 0.0833713276438768 no 279 0.0570766609831908 379 4580514 SGTC_1439 4092-1168 46 µM 1.57929861781316 0.0834386954693451 no 280 0.0571337893748402 355 2886240 SGTC_3296 9122258 64.045 µM 1.57724695280949 0.0837163565341577 no 281 0.0573693565635763 393 4730474 SGTC_1006 4099-6547 255 µM 1.57650700570097 0.0838166670376507 no 282 0.0574545027573226 378 3146833 SGTC_2112 5488546 200 µM 1.57456878664038 0.0840798485035787 no 283 0.0576780061710998 391 600757 SGTC_1667 st014849 34.6 µM 1.57414852352188 0.0841369957737955 no 284 0.0577265583890725 368 5348460 SGTC_1504 k297-0033 30 µM 1.57375715364901 0.0841902403630699 no 285 0.0577718015168565 307 4388117 SGTC_560 2332-1943 155 µM 1.57279698436449 0.0843209753835047 no 286 0.0578829170792624 363 21177716 SGTC_1442 4112-3290 3 µM 1.5697901505793 0.0847313663343149 no 287 0.0582319698750462 402 704353 SGTC_782 0083-0095 30.5 µM 1.56706409886632 0.0851047273663114 no 288 0.0585498548738633 434 3591729 An indicator and reagent. SGTC_855 0428-0020 25 µM 1.56592143079063 0.0852615938009469 no 289 0.0586835060147474 337 6812414 SGTC_709 3807-1509 243 µM 1.56502975031054 0.0853841548500665 no 290 0.0587879668756874 322 1886677 YPL242C IQG1 SGTC_2694 st077685 81.9 µM 1.56177825353002 0.0858321895742518 no 291 0.0591701182444936 388 2838096 SGTC_419 nsc-638432 893 µM 1.5565229285355 0.0865600554614518 no 292 0.0597918973892478 395 368090 SGTC_43 0570-0105 72.5 µM 1.55581581552492 0.086658342199542 no 293 0.0598759481102052 523 1114046 YDL195W SEC31 SGTC_1384 3089-0840 101 µM 1.5534784997091 0.0869838161196564 no 294 0.06015443092737 349 1069836 SGTC_2911 7942208 15.64 µM 1.55241421948831 0.0871323205629418 no 295 0.060281571625961 342 1243384 SGTC_428 3448-4153 16.5 µM 1.55221225993503 0.0871605223694986 no 296 0.0603057217790255 362 3834874 SGTC_3046 9092212 49.47 µM 1.55198377247589 0.0871924367732249 no 297 0.0603330532458496 361 25236637 SGTC_995 3931-2021 34.6 µM 1.55023898740417 0.0874364305969481 no 298 0.0605420826742139 383 730143 SGTC_3120 9124077 49.47 µM 1.54934387030347 0.0875618029685001 no 299 0.0606495395192675 368 18774327 YGL155W CDC43 SGTC_1942 st076330 65.2 µM 1.54893007704873 0.0876198052213272 no 300 0.0606992648889668 379 24208414 SGTC_86 0417-1630 471.922 µM 1.54809244480067 0.087737305604207 no 301 0.0608000204206553 548 3634867 SGTC_300 r073-0011 5.04 µM 1.54390761190205 0.0883261017451089 no 302 0.0613053579044497 451 2735780 SGTC_329 k048-0121 21.3 µM 1.54321749045593 0.0884234823949533 no 303 0.0613890074847842 371 6832902 SGTC_2752 diclazuril 33.15 µM 1.53926727668668 0.0889824233106503 no 304 0.0618695296197299 571 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_3245 9134821 49.47 µM 1.53867997788083 0.0890657480437938 no 305 0.0619412213428266 422 17014901 SGTC_1628 st004252 77.7 µM 1.53637092347111 0.0893939149295384 no 306 0.0622237169179947 415 692968 SGTC_2869 9037858 32.47 µM 1.53523025735566 0.0895563599319588 no 307 0.062363639249855 337 27187042 SGTC_832 4083-0019 164 µM 1.53437686064979 0.0896780376867497 no 308 0.062468483407667 604 1990758 SGTC_2168 5727979 200 µM 1.52876358088674 0.0904814467101068 no 309 0.063161531932847 374 695210 SGTC_1423 4048-0112 5.59 µM 1.52829091277341 0.0905493411957799 no 310 0.0632201625587346 402 X1423 SGTC_409 arachidonic acid 100 µM 1.52813922295477 0.0905711380761455 no 311 0.0632389874235078 400 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_3074 9116018 49.47 µM 1.52808349699501 0.0905791465270176 no 312 0.0632459041693502 360 17027303 SGTC_2623 humulene 100 µM 1.51952764442191 0.0918149642720736 no 313 0.0643148675230674 351 6187145 An anti-inflammatory. SGTC_2152 5568786 200 µM 1.51678264367282 0.0922140899012131 no 314 0.0646607852566538 411 5399883 SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.51517463851193 0.0924484910633153 no 315 0.0648640919504447 407 140250 A respiratory chain inhibitor. SGTC_2511 berberine 10.47 µM 1.51316218427588 0.0927424701039608 no 316 0.0651192336218681 377 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1478 0453-0656 35.7 µM 1.51297473734944 0.0927698874815045 no 317 0.0651430379907773 417 5258496 SGTC_363 0455-0021 3.06 µM 1.50999535835387 0.0932064786374383 no 318 0.0655223042859004 456 4597466 SGTC_929 2805-0021 398 µM 1.50998680423972 0.0932077343191809 no 319 0.0655233956597208 397 3098024 SGTC_3276 9139060 49.47 µM 1.50960631815573 0.0932635995534556 no 320 0.0655719541108441 320 4870619 SGTC_2534 helenine 20.12 µM 1.50794308031619 0.0935080965074441 no 321 0.0657845477518214 365 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_362 0310-0100 9.03 µM 1.50778037081457 0.0935320402976498 no 322 0.0658053737972746 443 790235 SGTC_90 0870-0863 4.608 µM 1.50553169032628 0.093863412484752 no 323 0.0660937178546167 458 1738164 SGTC_1660 st012960 28.1 µM 1.50537737285479 0.0938861848956728 no 324 0.0661135415266014 440 24207266 SGTC_1482 3346-2049 8.48 µM 1.50394756134946 0.0940973741061101 no 325 0.0662974346806858 409 3826804 SGTC_460 trequinsin 123 µM 1.49748326518704 0.0950565533644384 no 326 0.067133778409529 411 5537 A vasodilator. SGTC_2498 4'-Methoxychalcone 54.63 µM 1.49739562856983 0.0950696062758755 no 327 0.0671451725352377 412 641818 YHR062C RPP1 SGTC_791 1348-1292 225 µM 1.4951690066373 0.0954016903359031 no 328 0.067435170012315 514 5437054 SGTC_200 k038-0079 37.545 µM 1.49156429645769 0.0959411148794957 no 329 0.0679067019364176 407 3436683 SGTC_2962 9082311 13.18 µM 1.48783120434915 0.0965021119119144 no 330 0.0683977070948475 397 16459453 SGTC_3070 9117005 49.47 µM 1.48675113130424 0.0966648704400735 no 331 0.0685402763622685 331 8779016 SGTC_2553 4-methylesculetin 85.09 µM 1.48090188522375 0.0975498095883574 no 332 0.0693163603014905 439 5319502 SGTC_3258 9138477 49.47 µM 1.4739192423483 0.0986139837200448 no 333 0.0702516680726499 405 4970355 SGTC_355 1311-2252 105 µM 1.4683065459327 0.0994755156476306 no 334 0.0710104868233644 456 5338538 SGTC_1839 st053978 48 µM 1.46460169162434 0.100047205820441 no 335 0.071514810106641 430 3788398 SGTC_1131 3454-3128 32.3 µM 1.45571017964559 0.101429020863434 no 336 0.0727363773122633 505 710982 SGTC_674 0498-0004 451 µM 1.45510260253971 0.101523948341909 no 337 0.0728204293994982 443 4231473 SGTC_2652 actinonin 100 µM 1.45442420310879 0.101630017494973 no 338 0.0729143668795084 394 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_771 0250-0039 27.3 µM 1.4531167305134 0.101834671116639 no 339 0.073095673293913 456 3005115 SGTC_2537 larixol 68.93 µM 1.45272459290704 0.101896109333907 no 340 0.0731501179697657 475 6708759 SGTC_2270 7924575 90.91 µM 1.45210818719798 0.101992739314796 no 341 0.0732357629114166 471 1262135 SGTC_1226 3909-7979 35.4 µM 1.44854343987628 0.102552870067436 no 342 0.0737325631551222 502 6615510 SGTC_1145 3546-0597 10.2 µM 1.44667860602119 0.102846781860111 no 343 0.0739934795503026 472 875334 SGTC_2173 5763948 167 µM 1.4462503910712 0.102914358067921 no 344 0.0740534922974122 469 2867177 SGTC_3066 9117245 49.47 µM 1.44532466881897 0.103060555681506 no 345 0.0741833559353387 454 17176980 SGTC_1193 1488-0126 41.5 µM 1.44164697850894 0.103642856601515 no 346 0.0747009941737921 461 1384710 SGTC_1959 st077091 55.8 µM 1.4400523385502 0.103896081840311 no 347 0.0749262960038359 484 821356 YKL052C ASK1 SGTC_1195 1502-0147 41.1 µM 1.43742150491165 0.104314832600926 no 348 0.0752991309649256 485 817940 SGTC_2635 hydroquinidine 100 µM 1.43699219117841 0.104383282552282 no 349 0.0753601061925697 449 442912 An experimental heart treatment. SGTC_698 k064-0052 127 µM 1.43671946067437 0.104426783714477 no 350 0.0753988615220292 379 5088751 SGTC_3355 9151058 44.0485 µM 1.43439247629889 0.104798477507146 no 351 0.0757301467385394 444 17015728 SGTC_2197 6588183 93.1375 µM 1.43419418715509 0.104830194861672 no 352 0.0757584277067058 393 884136 SGTC_82 0054-0107 293.755 µM 1.43050815391378 0.105421060593923 no 353 0.0762856136293558 415 3104697 SGTC_252 miconazole 1.30953 nM 1.42876317563245 0.105701616669828 no 354 0.0765361564685284 439 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_742 0kpi-0133 140 µM 1.42837026032621 0.105764863637157 no 355 0.0765926572304012 475 2728852 SGTC_1452 4194-0072 190 µM 1.42829455471578 0.105777052994526 no 356 0.0766035472529286 505 1343545 SGTC_2510 benzyl isothiocyanate 8.31 µM 1.42588319928294 0.106165836691683 no 357 0.0769510298818906 424 2346 DNA damaging agent; causes G2/M arrest. SGTC_1204 4049-0315 18.3 µM 1.42538292729656 0.10624662485339 no 358 0.077023270219698 471 588402 SGTC_2732 terfenadine 20 µM 1.42525259789094 0.106267678839585 no 359 0.0770420985231466 384 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2091 4-phenylthiadiazole 200 µM 1.42255747038635 0.106703737249238 no 360 0.0774322401419751 478 270010 SGTC_1949 st076024 69.1 µM 1.4210872813585 0.106942150263094 no 361 0.0776456935087934 484 2921930 SGTC_1657 st012939 43.4 µM 1.42068547360409 0.107007376180214 no 362 0.0777041087114934 418 24207257 SGTC_2319 6033012 152.6 µM 1.41936179690686 0.107222453112126 no 363 0.0778967821059955 396 847246 SGTC_1990 st072050 59.8 µM 1.41841822010434 0.107375959881159 no 364 0.0780343496243943 465 17233948 SGTC_3035 9091303 49.47 µM 1.41812607836345 0.107423519364575 no 365 0.0780769793853879 411 25237002 SGTC_114 0364-0001 490.298 µM 1.41666277081399 0.10766196836503 no 366 0.0782907733302487 478 4003655 SGTC_3220 9131269 49.47 µM 1.41541052426503 0.107866327145636 no 367 0.0784740828511722 424 17722206 SGTC_2758 dehydroepiandrosterone 69.35 µM 1.41489968292382 0.107949773428315 no 368 0.0785489554921047 508 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1690 st023502 41.2 µM 1.4141895843922 0.108065845716651 no 369 0.0786531226571417 447 24207482 SGTC_510 ag-490 170 µM 1.41104038730553 0.108581694528146 no 370 0.0791163528629274 485 5328779 SGTC_963 1269-2853 151 µM 1.40643044111895 0.109340009283006 no 371 0.0797981731181298 468 3668223 SGTC_2673 kobusone 100 µM 1.40217576535459 0.110043252790692 no 372 0.0804313833166024 435 6710676 An epoxy ketone and protein crosslinker. SGTC_2810 7959871 45.46 µM 1.40180081338653 0.110105382794834 no 373 0.0804873677581866 553 2974535 SGTC_463 ikarugamyin 104 µM 1.39990037968651 0.110420674018737 no 374 0.0807715761710077 364 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.39862494244194 0.110632637961922 no 375 0.0809627413508278 523 23665772 A membrane-active detergent. SGTC_1591 genipin 88.4 µM 1.39809038360642 0.110721562557139 no 376 0.081042963624389 426 442424 A DNA cross-linking agent. SGTC_528 3492-0019 172 µM 1.39448060572748 0.111323394999509 no 377 0.0815862610478292 714 2869262 SGTC_1412 3909-8563 178 µM 1.39309418558407 0.111555164199532 no 378 0.0817956555740382 528 23767530 SGTC_32 0928-0142 34.1 µM 1.39294956923198 0.111579359726527 no 379 0.0818175206548425 428 2244242 SGTC_833 3852-0053 558 µM 1.39144620876546 0.111831106951892 no 380 0.082045080274033 540 3123681 SGTC_70 0141-0289 43.283 µM 1.38992847654742 0.112085672624184 no 381 0.0822752986805428 713 352408 SGTC_1376 2910-0861 41.3 µM 1.38945432785356 0.112165285331668 no 382 0.0823473199404175 518 1112859 SGTC_170 4197-0004 226 µM 1.38731862079634 0.112524385739963 no 383 0.0826723137670673 432 218692 SGTC_2655 perillic acid 100 µM 1.38430688848203 0.1130321765604 no 384 0.0831322528402553 429 5702197 An apoptosis inducer. SGTC_1659 st012954 42.1 µM 1.38010647795962 0.113743111351592 no 385 0.0837769315198489 470 24207262 SGTC_1957 st077035 62.4 µM 1.37785050410305 0.114126256073015 no 386 0.0841247246476851 483 705593 SGTC_3241 9133421 49.47 µM 1.37667845875673 0.11432567359158 no 387 0.0843058407822626 398 17018221 SGTC_1868 st057644 42.7 µM 1.36923252846797 0.115598356465928 no 388 0.0854633005293815 530 688665 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.365342750774 0.116267198073111 no 389 0.0860726741371799 415 4620898 SGTC_96 0929-0093 37.281 µM 1.36055433578478 0.117094323884443 no 390 0.0868272853419379 476 6991579 SGTC_345 1362-0200 395 µM 1.35613970323247 0.117860570329845 no 391 0.0875273612174905 476 1419823 SGTC_508 roscovitine 141 µM 1.35379908607802 0.118268266679189 no 392 0.0879002426680416 494 160355 A CDKinase inhibitor. SGTC_126 0417-1624 672.48 µM 1.35305485560531 0.118398107861374 no 393 0.0880190531892412 633 41912 YDL195W SEC31 SGTC_2713 st079149 53.4 µM 1.35092919529887 0.118769513163907 no 394 0.0883590574569957 542 3103253 SGTC_2824 7998404 51.95 µM 1.35055765485712 0.118834514852202 no 395 0.0884185865582851 480 837851 SGTC_2134 5324836 1.464 µM 1.3493472579476 0.11904645028943 no 396 0.0886127265118147 435 699272 SGTC_1516 st013856 110 µM 1.34749214053261 0.11937179130809 no 397 0.088910891507777 477 5281404 A mutagen and neurotoxin. SGTC_1335 1486-0900 202 µM 1.34484834573583 0.119836529949622 no 398 0.0893371070255645 553 X1335 SGTC_509 pifithrin 175 µM 1.34392219186052 0.119999634940259 no 399 0.0894867745025252 488 4817 A p53 inhibitor. SGTC_789 1309-1135 70.6 µM 1.34254080931259 0.120243200906061 no 400 0.0897103538160864 539 3092424 SGTC_854 0422-0053 192 µM 1.34244730012088 0.120259701064778 no 401 0.0897255034453725 498 3596728 SGTC_2773 thioridazine 9.09 µM 1.3417889527578 0.12037591485948 no 402 0.0898322175829654 528 5452 An antipsychotic. SGTC_1191 1487-1166 10.6 µM 1.34119170064301 0.120481412319124 no 403 0.0899291101353761 601 3955771 SGTC_3312 9133330 71.43 µM 1.33999168017892 0.120693578419693 no 404 0.0901240249009672 538 17617324 SGTC_3254 9136651 49.47 µM 1.33941966261528 0.120794804822972 no 405 0.0902170459248821 543 16454030 SGTC_2712 st079126 47.7 µM 1.33933515343288 0.120809764954026 no 406 0.0902307947825568 482 3152970 SGTC_3121 9125696 49.47 µM 1.33866383995951 0.120928649695597 no 407 0.090340066527976 461 1235365 SGTC_15 0266-0086 27.098 µM 1.33856096475494 0.12094687541925 no 408 0.0903568205195502 625 1712902 YIL048W NEO1 SGTC_898 1000-0849 28.3 µM 1.33329958535726 0.121881577770956 no 409 0.0912167548584746 527 6751807 SGTC_22 0964-0034 14.468 µM 1.33150275938212 0.122201949514723 no 410 0.0915118188252133 554 138402 SGTC_1513 0337-0559 19 µM 1.32950185631426 0.122559403160873 no 411 0.0918412268868859 470 775073 SGTC_2087 5276107 200 µM 1.32938409830499 0.122580463010555 no 412 0.0918606406820074 510 144405 SGTC_323 4013-0906 34.3 µM 1.32796182870015 0.122835022321303 no 413 0.0920953586828725 507 2910086 SGTC_748 act1.228 77.9 µM 1.3276811066663 0.12288531002074 no 414 0.0921417388307705 585 4421505 YNR035C ARC35 SGTC_544 k015-0020 52.4 µM 1.32753079708113 0.122912241960319 no 415 0.0921665796876914 505 3008304 SGTC_1473 k844-0725 134 µM 1.32513214358969 0.12334258427248 no 416 0.0925636633035686 590 54682906 SGTC_1756 st041558 35.5 µM 1.32481688359324 0.123399223447859 no 417 0.0926159467820952 579 3955792 SGTC_1378 2093-0007 380 nM 1.32210604040538 0.123887001775738 no 418 0.0930664213314032 534 3618014 SGTC_947 3447-0010 211 µM 1.32141805015244 0.124011010425607 no 419 0.0931810053911559 507 748350 SGTC_1174 0739-0097 51.1 µM 1.32048346917681 0.124179605586828 no 420 0.0933368258303659 555 728447 SGTC_1486 3970-0793 4.53 µM 1.3202137839802 0.124228285656237 no 421 0.0933818255635948 528 2844330 SGTC_760 0568-0725 82.9 µM 1.32016540453157 0.124237019897949 no 422 0.093389899864522 537 3916171 SGTC_3140 9094243 49.47 µM 1.31560886784138 0.125061565772825 no 423 0.0941526778159548 542 19291112 SGTC_8 0354-0001 70 µM 1.31000535398272 0.126080801919496 no 424 0.0950970121895795 647 4993152 SGTC_3113 9123498 49.47 µM 1.3071604275539 0.126600482680451 no 425 0.0955791160661746 520 8897275 SGTC_2495 cafestol 54.53 µM 1.30673803067414 0.126677768645572 no 426 0.095650848906998 503 16667697 An anti-infammatory. SGTC_2826 7992541 19.48 µM 1.30592066493391 0.126827415362111 no 427 0.095789769147784 514 2985066 SGTC_1819 st053448 58.6 µM 1.30091842245798 0.127745928068653 no 428 0.096643189763899 529 2857616 SGTC_2062 5245942 200 µM 1.29986713924576 0.127939551372408 no 429 0.0968232547122963 576 1376160 SGTC_499 genistein 192 µM 1.29615907672995 0.128624122713299 no 430 0.0974603426087988 487 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_297 0986-0032 24 µM 1.29598252134726 0.128656781112172 no 431 0.0974907533635231 497 2847425 SGTC_2154 5570129 200 µM 1.29187336757027 0.129418499075503 no 432 0.0982005010750783 594 673366 SGTC_2321 7390090 138.78 µM 1.28932265636211 0.129892895899781 no 433 0.0986429688060471 492 649046 SGTC_1680 diphenhydramine 100 µM 1.28527233614959 0.13064867034359 no 434 0.0993485668382348 544 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1327 1436-0082 2.18 µM 1.28186354211951 0.131287090195195 no 435 0.0999452595761149 551 15992205 SGTC_1852 st056254 31.4 µM 1.28127401546396 0.13139771849783 no 436 0.100048718239452 545 442583 SGTC_3301 9125354 19.7965 µM 1.28073167596271 0.131499548666216 no 437 0.100143964858775 495 41905162 SGTC_1664 st014217 9.02 µM 1.28012311259257 0.131613877933966 no 438 0.100250920627139 587 3982782 SGTC_615 k087-0205 167 µM 1.27733935336884 0.132137730286093 no 439 0.100741232871114 534 9642773 SGTC_3079 9117512 49.47 µM 1.27579301462802 0.132429343104811 no 440 0.101014348766826 559 7185044 SGTC_2832 7992762 51.95 µM 1.27501454174763 0.132576317372892 no 441 0.101152047504553 488 2985177 SGTC_1964 st076914 61 µM 1.27174726925786 0.133194397847776 no 442 0.101731464891158 539 24208661 SGTC_2624 nerol 100 µM 1.27131842240228 0.133275671167209 no 443 0.101807695529335 539 637566 A natural product oil. SGTC_1146 3579-1023 7 µM 1.26706005861327 0.134084550730238 no 444 0.10256690790084 627 X1146 SGTC_469 w7 172 µM 1.26672899194341 0.13414757810612 no 445 0.102626104871843 509 45115570 A P450 inhibitor. SGTC_2614 arthonioic acid 13.39 µM 1.26024639440833 0.135385815243202 no 446 0.103790245573726 513 6710684 SGTC_2687 chenodiol 100 µM 1.2567366836449 0.136059461621961 no 447 0.104424500013831 550 5702181 A cholesterol synthesis inhibitor. SGTC_1436 4092-1007 8.32 µM 1.25386317870732 0.136612701544341 no 448 0.104945870295423 546 2881121 SGTC_2267 7931562 200 µM 1.25368427580608 0.136647196765334 no 449 0.104978392738118 517 934880 SGTC_2677 mitomycin C 100 µM 1.25168572519815 0.137032952847987 no 450 0.105342201811763 526 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_149 3970-0822 46.1 µM 1.2514343747268 0.137081520616984 no 451 0.105388021251724 734 3114250 YBL034C STU1 SGTC_900 1112-0045 141 µM 1.2508156483535 0.137201125536407 no 452 0.105500872177536 454 56211 YIL048W NEO1 SGTC_2868 9035608 32.47 µM 1.24994740301133 0.137369084701737 no 453 0.105659380774538 587 6462614 SGTC_1049 3226-0134 66 µM 1.24933744939524 0.137487162124817 no 454 0.105770838045112 617 5702385 SGTC_2731 amoxapine 43.43 µM 1.24879433730469 0.137592358381719 no 455 0.105870152824689 453 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_484 loperamide 105 µM 1.24834964922547 0.137678531630564 no 456 0.105951519724252 479 3955 An opioid-receptor agonist. SGTC_879 0831-1030 162 µM 1.24666577032788 0.138005173471036 no 457 0.106260037378629 651 1549252 SGTC_1526 st051518 75 µM 1.24497589441654 0.138333509609144 no 458 0.106570305595551 542 673993 SGTC_2224 6650123 117.647 µM 1.24456280186244 0.138413852765998 no 459 0.106646250472625 528 2908370 SGTC_1240 0356-0016 42.1 µM 1.24396308327881 0.138530549763343 no 460 0.106756575064714 592 4305613 SGTC_1250 0485-0349 40.2 µM 1.24196396345153 0.138920035120186 no 461 0.107124929153613 565 6842794 YDL195W SEC31 SGTC_99 0109-0120 622.8 µM 1.23911671194574 0.139476046735617 no 462 0.107651139435408 538 759414 SGTC_2305 7443522 69.23 µM 1.23828368311904 0.139639006524154 no 463 0.107805445897727 616 5415886 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.23722548298144 0.139846201671757 no 464 0.108001691715983 616 442882 SGTC_2733 amorolfine 100 µM 1.23521678600464 0.140240078269619 no 465 0.108374916818458 474 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_36 0335-0881 14.2 µM 1.23360503465953 0.140556663884401 no 466 0.108675058019621 651 23828853 SGTC_2728 chlorpromazine 9.18 µM 1.23163157062418 0.140944958511183 no 467 0.109043371079314 497 2726 A thorazine and dopamine antagonist. SGTC_599 1935-0052 86.5 µM 1.22602571282074 0.142051921432669 no 468 0.11009449953483 630 9557311 SGTC_1365 1672-3266 55.4 µM 1.22364173987296 0.142524452344424 no 469 0.110543703224798 636 6415873 SGTC_2181 6316240 54.2555 µM 1.21722110102876 0.143802379144857 no 470 0.111760051925284 555 12779990 SGTC_2044 5102272 200 µM 1.21631739889147 0.143982865486971 no 471 0.111932018064303 557 592666 SGTC_2378 9074213 121.43 µM 1.21575815715993 0.144094633092398 no 472 0.112038531309941 623 657714 SGTC_3263 9137018 49.47 µM 1.21565860607021 0.144114535069975 no 473 0.112057499417311 577 43844957 SGTC_2481 5478948 45.16 µM 1.21137593127158 0.144972470700871 no 474 0.112875679771035 591 77792 SGTC_25 0118-0223 35.662 µM 1.21137564166922 0.144972528832077 no 475 0.112875735241719 590 5333628 SGTC_1352 1496-0991 99 µM 1.21086341849785 0.145075370751057 no 476 0.112973877361057 611 3000039 SGTC_553 k007-0256 45.7 µM 1.20923619216721 0.145402403813861 no 477 0.11328605845822 620 6287000 SGTC_1342 1486-1464 234 µM 1.2086718351189 0.14551594163017 no 478 0.113394473157817 636 3253938 SGTC_2216 7189485 200 µM 1.20206892017629 0.146848750686161 no 479 0.114668413368181 627 731273 SGTC_1873 rapamycin 2 nM 1.20061551487094 0.147143219048351 no 480 0.114950189955243 649 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_516 3992-2719 87.3 µM 1.19915319816752 0.147439892170323 no 481 0.115234190884935 567 5350887 YDR037W KRS1 SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.19805592928984 0.147662767836959 no 482 0.115447622093274 675 165506 SGTC_2502 avocadyne acetate 18.59 µM 1.19785732719682 0.147703131710932 no 483 0.115486282450595 690 3952079 SGTC_1051 3253-3903 78 µM 1.19475197201683 0.14833522490175 no 484 0.116091975058813 648 5509239 SGTC_1554 st069299 38.7 µM 1.19417251595046 0.148453372859504 no 485 0.116205245845398 624 24207999 SGTC_2427 5545055 42.75 µM 1.19324128030038 0.148643378575324 no 486 0.116387445987198 682 5372858 SGTC_1080 nisoldipine 24.4 µM 1.19025003522664 0.149254800027764 no 487 0.116974066285588 648 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1466 k213-0079 57.5 µM 1.18995252943353 0.149315702989186 no 488 0.117032525226009 634 3657981 SGTC_3324 9138759 60.749 µM 1.18971652563734 0.149364027562944 no 489 0.117078913942788 617 45595710 SGTC_1617 st002906 78 µM 1.1884584125046 0.149621817307909 no 490 0.117326427499077 642 5150859 SGTC_1020 4335-0961 93.3 µM 1.1882552780858 0.149663467752166 no 491 0.117366425656679 577 669075 SGTC_620 0109-0052 432 µM 1.18428399609672 0.150479288701079 no 492 0.118150330899405 649 493037 SGTC_2813 7971799 71.43 µM 1.18332742976006 0.150676238139155 no 493 0.118339702957084 594 2234054 SGTC_1337 1486-1011 40.3 µM 1.18119498197723 0.151115909862042 no 494 0.118762637133407 620 X1337 SGTC_1161 k007-0610 110 µM 1.17582166011296 0.152227572479262 no 495 0.119833074498317 731 5843850 SGTC_1985 st071382 65.5 µM 1.17562550296271 0.152268257017794 no 496 0.119872279903408 643 6123237 SGTC_998 3996-0085 177 µM 1.17557520676233 0.152278690008687 no 497 0.119882333926929 704 715391 SGTC_3145 9085516 49.47 µM 1.17275736957504 0.152863954851103 no 498 0.12044655901869 607 25236195 SGTC_3243 9134147 49.47 µM 1.17161805035109 0.153101014388253 no 499 0.120675218899845 669 24282180 SGTC_2338 7999974 200 µM 1.1706147130794 0.153309981669012 no 500 0.120876840300975 704 315925 SGTC_1933 st074711 15.9 µM 1.16708473221286 0.154046679930333 no 501 0.121588076477321 686 17250958 SGTC_3351 9150312 21.596 µM 1.16704293982024 0.154055415904267 no 502 0.121596514574212 659 4904905 SGTC_2343 7990716 14.84 µM 1.1668608820212 0.154093475749419 no 503 0.121633277772559 665 6456862 SGTC_1962 st076595 64.5 µM 1.16606040737172 0.154260891681327 no 504 0.12179501146717 651 279619 SGTC_1268 0828-0275 2.46 µM 1.16353484372621 0.154789890967969 no 505 0.122306284802561 672 745337 SGTC_2516 gossypol 71.55 µM 1.16317539726059 0.154865277180909 no 506 0.122379173176968 690 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_371 0195-0006 7.36 µM 1.16282345787916 0.154939112436963 no 507 0.122450568801276 570 3928593 SGTC_162 k030-0015 37.8 µM 1.16275951448567 0.154952529960893 no 508 0.122463543713475 670 1809920 YMR134W ERG29 SGTC_920 mycophenolic acid 780.421 nM 1.16167776116718 0.155179635325597 no 509 0.122683191182951 651 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1244 0416-0015 52.5 µM 1.16111120021504 0.155298667852639 no 510 0.122798340255333 631 96201 SGTC_2889 9059656 51.95 µM 1.1513228869533 0.157364671306842 no 511 0.124799712435282 707 3949838 SGTC_1743 st037606 46.3785 µM 1.14953675175599 0.157743608281145 no 512 0.125167360664492 658 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_488 nitrendipine 139 µM 1.14840299118786 0.157984451629795 no 513 0.12540111972383 694 4507 Dihydropyridine L-type calcium channel blocker. SGTC_3031 9088762 49.47 µM 1.1469644648441 0.158290383303575 no 514 0.125698153845668 673 205253 SGTC_3022 9087993 49.47 µM 1.14316771952094 0.159099703524548 no 515 0.126484481022064 639 17173644 SGTC_1289 0976-0073 69.1 µM 1.14312051239225 0.159109783302662 no 516 0.126494279402835 707 3391136 SGTC_1075 aripiprazole 15.2 µM 1.14283132033817 0.159171541407247 no 517 0.126554316070875 714 60795 An atypical antipschotic. YIL048W NEO1 SGTC_675 1309-0189 238 µM 1.13890097793995 0.160012438127072 no 518 0.127372228847665 671 4246530 SGTC_3098 9119039 49.47 µM 1.13737302537109 0.160340126344624 no 519 0.127691189422783 666 17161528 SGTC_2656 pseudo-anisatin 100 µM 1.13725818475534 0.160364773033792 no 520 0.127715184850281 649 6708809 A neurotoxin. SGTC_191 3914-0123 66.505 µM 1.13602421872049 0.160629758696889 no 521 0.127973214256038 524 3144412 SGTC_3080 9117754 49.47 µM 1.13601935613174 0.160630803469532 no 522 0.127974231767269 732 9550191 SGTC_723 4182-0001 115 µM 1.13290157886931 0.161301600779541 no 523 0.128627793450672 640 744821 YLR208W SEC13 SGTC_1707 st032323 6.317 µM 1.13266060396554 0.161353523072973 no 524 0.128678403884707 694 3132057 YMR211W DML1 SGTC_3331 9141060 1.957 µM 1.13227619624592 0.161436373057975 no 525 0.12875916720366 629 4906567 YPR165W RHO1 SGTC_3175 9106517 49.47 µM 1.13133366137135 0.161639631514978 no 526 0.128957340761122 650 41468073 SGTC_479 n-linoleoylglycine 10 µM 1.12955136734182 0.162024440513974 no 527 0.129332656618805 642 6433346 An anti-infammatory. SGTC_3005 9076496 71.4286 µM 1.12844288218237 0.162264070457279 no 528 0.129566463122971 644 21368410 SGTC_957 1187-1561 14.1 µM 1.12823421319834 0.162309205862545 no 529 0.129610509218718 689 1538454 SGTC_2964 9083345 53.42 µM 1.12664227495659 0.162653813406785 no 530 0.129946878823995 623 17741579 SGTC_1362 1611-0397 101 µM 1.12650946973357 0.162682583303291 no 531 0.129974967273302 683 27816 SGTC_2855 9016525 58.44 µM 1.12605809030546 0.162780391395138 no 532 0.130070465930089 678 43811474 SGTC_77 0828-0286 12.516 µM 1.12472919870943 0.163068567027886 no 533 0.130351902346026 682 745345 SGTC_380 3970-0968 6 µM 1.12114744578936 0.163846935249389 no 534 0.13111255283257 659 2891601 SGTC_2842 9000675 19.48 µM 1.12063307513872 0.163958913322788 no 535 0.131222040081833 632 2989072 SGTC_2449 5812982 45.77 µM 1.11848183819728 0.164427773823441 no 536 0.131680629521834 644 776185 SGTC_3088 9117578 49.47 µM 1.11735082502341 0.164674625553773 no 537 0.131922176055833 675 678341 SGTC_1104 tacrolimus 29.8 µM 1.11639936953206 0.164882473393598 no 538 0.132125611635506 730 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2969 9091408 28.7 µM 1.11638977950118 0.164884569224422 no 539 0.132127663229713 662 4286311 SGTC_1574 spiramycin 23.7 µM 1.11611377293654 0.164944895826106 no 540 0.132186718695712 685 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2674 ligustilide 100 µM 1.11374154141346 0.165463982397329 no 541 0.132695041173752 651 5319022 A signalling regulator. SGTC_215 1287-0124 461.5 µM 1.10675869034424 0.166998080961666 no 542 0.134199136455254 663 5560863 SGTC_2135 5326629 150.42 µM 1.10563639358583 0.167245497020815 no 543 0.134441965461898 634 5020077 SGTC_248 streptozotocin 5.23457 mM 1.1026551576563 0.167903872519662 no 544 0.135088473632284 734 5300 DNA alkylating agent. SGTC_885 0865-0106 16.8 µM 1.10146175826729 0.168167889549414 no 545 0.135347869722734 694 2793380 SGTC_1476 4112-3294 3.34 µM 1.09699450118699 0.16915855538702 no 546 0.136321897936472 693 704369 SGTC_1233 0325-0408 14.2 µM 1.09514247318952 0.169570360535741 no 547 0.13672711179107 710 12874 SGTC_174 3553-0389 74.3 µM 1.09339742934923 0.169958965373801 no 548 0.137109670866312 648 738071 SGTC_1625 st003711 30.1 µM 1.09325164816335 0.169991455290469 no 549 0.137141662965248 709 24207034 YER133W GLC7 SGTC_2026 5148700 152 µM 1.09136898844452 0.170411396980558 no 550 0.137555276224014 699 79838 SGTC_3122 9126309 49.47 µM 1.09111417508673 0.17046828606167 no 551 0.137611323117239 697 17591206 SGTC_2679 rapamycin 1 nM 1.09007074909698 0.17070136594822 no 552 0.137840990090018 801 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1546 5-methoxyflavanone 78.7 µM 1.09001261978028 0.170714356836841 no 553 0.13785379253487 758 147795 SGTC_557 1315-0110 16.2 µM 1.088208095832 0.171117951181784 no 554 0.138251625766604 718 6833801 SGTC_404 fumagillin 50 µM 1.08553729502928 0.171716413356718 no 555 0.138841877448356 738 12015870 A methionine aminopeptidase binder. SGTC_583 1488-1091 88.9 µM 1.08540873886873 0.171745253383736 no 556 0.138870331810843 841 4303273 SGTC_3337 9144342 33.5465 µM 1.08452588457606 0.17194339468821 no 557 0.13906584827897 737 17682949 SGTC_482 fipronil 114 µM 1.0844296415339 0.171965003585688 no 558 0.139087173535842 673 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1880 MG-132 525 µM 1.08274452110277 0.172343634912444 no 559 0.139460918375889 670 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2611 pyromycin 23.93 µM 1.08153535684042 0.172615650663618 no 560 0.139729520921436 691 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_3028 9087778 49.47 µM 1.08120651888759 0.172689673956122 no 561 0.139802629447807 712 17217395 SGTC_1952 st077036 64.1 µM 1.07951934844788 0.173069783816818 no 562 0.140178136616127 715 2937007 SGTC_3208 9114115 49.47 µM 1.07763676133001 0.173494548559724 no 563 0.140597945016258 632 650895 SGTC_1052 3253-3998 198 µM 1.07757460593761 0.173508583874292 no 564 0.14061181992442 760 5450317 SGTC_181 1447-1644 8.07 µM 1.07535740149034 0.174009723602399 no 565 0.141107372965737 734 534600 SGTC_2120 5538279 151.968 µM 1.07500043341048 0.174090492604554 no 566 0.141187267143494 727 2058197 SGTC_1441 4106-0040 13 µM 1.0726108279672 0.174631787709923 no 567 0.141722882230459 734 2904180 SGTC_282 k297-0036 65.7 µM 1.07080326915228 0.175041946330248 no 568 0.142128948341301 694 5061378 SGTC_367 0335-0881 7.1 µM 1.0700494284855 0.175213183035042 no 569 0.142298530278367 753 23828853 SGTC_3154 9100113 49.47 µM 1.06830178169957 0.175610573646837 no 570 0.142692202530601 714 25237525 SGTC_2391 6285546 200 µM 1.06740053861659 0.17581572683874 no 571 0.142895502675846 756 846083 SGTC_1065 prochlorperazine maleate 2.48 µM 1.06686462510132 0.175937790696761 no 572 0.143016485464235 756 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1281 0884-0031 11.8 µM 1.06683472805985 0.175944601861049 no 573 0.143023236776385 760 1548255 SGTC_706 4262-0057 46.9 µM 1.06507607023198 0.176345554255402 no 574 0.143420753588241 702 883298 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.06422059833835 0.176540800184714 no 575 0.143614388922929 789 676296 Flavone; oxidizing agent. SGTC_1474 0330-0125 5.35 µM 1.06170758306276 0.177115140639609 no 576 0.144184227879209 746 X1474 SGTC_2071 5230951 39.92 µM 1.06123667342472 0.177222896486349 no 577 0.144291178383719 783 1799272 SGTC_1608 st001473 40.5 µM 1.05571465642762 0.178489559437714 no 578 0.145549299517845 722 7292267 SGTC_1782 st039423 80.636 µM 1.05482820731811 0.178693426697394 no 579 0.145751950721136 692 2068169 SGTC_1638 st008370 60.6 µM 1.05467041882803 0.178729730561077 no 580 0.145788042636028 729 24207134 SGTC_3280 9140961 49.47 µM 1.05170488785277 0.179412901394689 no 581 0.146467483884294 712 4901226 SGTC_2779 methotrexate 400 µM 1.04937321296516 0.179951201758241 no 582 0.147003190935959 787 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2436 5633522 8.09 µM 1.04774414574244 0.18032789634069 no 583 0.147378251193474 766 5724242 SGTC_92 0063-0024 660.874 µM 1.04771533287573 0.180334563284791 no 584 0.147384890547752 830 3594437 SGTC_3161 9100388 49.47 µM 1.04735605943551 0.180417707741565 no 585 0.147467694825233 785 25236368 SGTC_2146 5545642 200 µM 1.04669850121159 0.180569944700603 no 586 0.147619327611684 759 825326 SGTC_1092 toremifene 6.32 µM 1.04571728319773 0.180797264677949 no 587 0.147845790405326 811 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2388 9080168 200 µM 1.04425075409757 0.181137351530078 no 588 0.148184695261225 701 15943073 SGTC_2016 5121758 140 µM 1.04229367408649 0.181591820482388 no 589 0.148637772164588 803 2795203 SGTC_2206 7254556 146.969 µM 1.04220411929195 0.181612633765717 no 590 0.148658526823615 715 4398905 SGTC_101 0490-5701 117.494 µM 1.04212144115464 0.181631850181632 no 591 0.148677689511371 718 4661669 SGTC_2070 5230947 200 µM 1.03485846744348 0.183324905511636 no 592 0.150367506603752 805 2835538 SGTC_932 2857-0803 154 µM 1.03411300876111 0.183499232795812 no 593 0.150541667716688 817 674898 SGTC_2189 6047310 154.431 µM 1.03347645389212 0.183648174421695 no 594 0.15069049200146 742 711535 SGTC_1108 betulinic acid 729.144 nM 1.03292293468181 0.183777748508228 no 595 0.150819982450009 777 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1349 flufenamic acid 69 µM 1.03259667857223 0.183854148927125 no 596 0.150896341590529 742 3371 A non-steroidal anti-inflammatory. SGTC_2440 5628896 157.78 µM 1.03123187761832 0.184173963071906 no 597 0.151216047585846 762 5522048 SGTC_2800 7887935 81.82 µM 1.02958986643404 0.18455919454298 no 598 0.151601287114237 732 2961002 SGTC_1076 itraconazole 331 nM 1.0226303195129 0.18619752730991 no 599 0.153241334256649 807 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1902 st060212 70.5 µM 1.02174247599952 0.186407179074595 no 600 0.153451400821543 783 688944 SGTC_1518 st038567 90.8 µM 1.02165746266156 0.186427261447588 no 601 0.153471525245798 770 77966 SGTC_1781 st038725 66.3 µM 1.02142334078517 0.186482574082623 no 602 0.153526955796017 842 4270275 YIL048W NEO1 SGTC_2895 9054447 58.44 µM 1.01944636802707 0.186950050426153 no 603 0.153995551271738 759 2697450 SGTC_1290 0986-0249 10.2 µM 1.01902257895495 0.187050354176178 no 604 0.15409612367224 715 53329 SGTC_2287 7945887 168.79 µM 1.01773635432561 0.187354985718649 no 605 0.154401632801982 833 1245853 SGTC_582 0987-0078 156 µM 1.01772751375524 0.187357080594475 no 606 0.154403734033727 892 1625765 SGTC_2467 5474540 200 µM 1.01601773789147 0.187762504017093 no 607 0.154810469929245 785 5413519 SGTC_308 4092-1169 104 µM 1.0132170163249 0.188427783081874 no 608 0.155478257176561 828 2268590 YDL196W YDL196W SGTC_2468 5987765 72.9 µM 1.01173734950465 0.18877984705139 no 609 0.155831826179689 817 26772094 SGTC_2699 st077704 54.6 µM 1.01139378866532 0.188861650026939 no 610 0.155913996422636 783 645852 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.00937823359675 0.189342000196182 no 611 0.156396636613361 756 4330530 SGTC_400 oxethazaine 37.5 µM 1.00856134810318 0.18953689556671 no 612 0.156592526045472 764 4621 A local anesthetic. SGTC_2622 2-methoxyxanthone 59.94 µM 1.00826471915376 0.189607696866637 no 613 0.156663697731618 845 71034 A hepatoprotective. SGTC_281 1672-3440 14.9 µM 1.00550308251135 0.190267642633906 no 614 0.157327332961308 849 6833000 SGTC_2979 9012552 45.46 µM 1.00473967782117 0.190450321402035 no 615 0.157511108526133 744 17100905 SGTC_1687 st020778 55.3625 µM 1.00231834338827 0.191030446324862 no 616 0.158094932963502 901 4259299 SGTC_1107 amlodipine 47 µM 1.00182290091566 0.191149282282987 no 617 0.158214567306403 779 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2214 7179297 48.276 µM 1.00105008711384 0.191334738508637 no 618 0.158401297000184 806 769744 SGTC_68 0986-0284 82.829 µM 1.00060303455728 0.191442070411529 no 619 0.158509381219128 661 423278 YIL048W NEO1 SGTC_1669 st015249 58.4 µM 0.996233695610842 0.192493037102193 no 620 0.159568305512463 840 722793 SGTC_1283 0922-0125 16.4 µM 0.996171416499985 0.192508042684002 no 621 0.159583432460187 855 3360884 SGTC_2922 7999257 32.47 µM 0.995544690503523 0.192659086379912 no 622 0.159735709923477 733 2988377 SGTC_3333 9141820 12.094 µM 0.993959791962658 0.193041376863089 no 623 0.160121221463271 746 1939433 SGTC_2155 5570423 76 µM 0.993882928305886 0.193059928774285 no 624 0.160139933271726 746 797402 SGTC_1512 0259-0544 12.2 µM 0.992896549990253 0.193298098925487 no 625 0.160380185626129 848 18476 SGTC_2344 7990960 76.95 µM 0.991197821000535 0.193708692804574 no 626 0.160794497186913 766 140813 SGTC_197 4544-0043 41.561 µM 0.99044366526732 0.19389114748217 no 627 0.160978655812768 830 896523 SGTC_2892 9047358 58.44 µM 0.988920399607639 0.194259994033949 no 628 0.161351044427281 740 6466771 SGTC_332 4112-0506 40.9 µM 0.985358236925174 0.195124209576948 no 629 0.162224068011764 817 2790355 SGTC_3273 9137859 49.47 µM 0.984643149942409 0.195297977903012 no 630 0.162399693263357 823 2377234 SGTC_313 3474-0040 5.03 µM 0.984264350309665 0.195390065456241 no 631 0.162492776514409 824 1043375 YIL048W NEO1 SGTC_2342 7990637 118.86 µM 0.983858048612306 0.195488868173444 no 632 0.162592656490398 824 2033102 YER133W GLC7 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.982658952686064 0.195780636083384 no 633 0.162887659625071 859 6708561 SGTC_2147 5545932 89.7195 µM 0.981913537559531 0.195962146055032 no 634 0.163071222933364 802 797404 SGTC_3275 9138069 49.47 µM 0.981714181289214 0.196010706975888 no 635 0.163120338487358 816 17617007 SGTC_2386 9075165 157.42 µM 0.979595612563582 0.196527217101238 no 636 0.163642885761432 815 16452277 SGTC_810 3825-7150 143 µM 0.978130372400653 0.196884926737329 no 637 0.164004923887092 884 22330411 YGL099W LSG1 SGTC_2893 9048488 25.97 µM 0.977680942565005 0.196994725163151 no 638 0.164116075091526 794 6467338 SGTC_1393 3470-5649 58.2 µM 0.976029145446985 0.197398587515904 no 639 0.164525010701048 710 4108395 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.975957033153609 0.197416230281909 no 640 0.164542878582091 857 688664 SGTC_156 3474-0145 5.642 µM 0.975637838785149 0.197494334819375 no 641 0.164621983209303 823 2265471 SGTC_3256 9138902 49.47 µM 0.975618635205363 0.197499034391257 no 642 0.164626743139231 856 17228773 SGTC_3131 9127911 49.47 µM 0.974956173323918 0.197661195936177 no 643 0.164791000048855 787 45595681 SGTC_3082 9117008 49.47 µM 0.97311902049085 0.198111326501064 no 644 0.165247075891989 836 41448529 SGTC_1396 3511-0007 98.6 µM 0.972971970602222 0.198147382707915 no 645 0.165283616515192 738 X1396 SGTC_1299 1079-1439 3.74 µM 0.971041196864767 0.198621170268784 no 646 0.165763882055833 791 323161 SGTC_1276 0871-0068 94.2 µM 0.970225860299546 0.198821448601314 no 647 0.165966961597515 822 3414906 SGTC_1993 st073995 70.8 µM 0.964845265901309 0.20014618160538 no 648 0.167311159806063 855 3098394 SGTC_2942 9052777 62.25 µM 0.964140847100113 0.200320005410959 no 649 0.167487658081368 900 6469503 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.96312568710009 0.200570667822165 no 650 0.167742226196094 833 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1274 0865-0114 173 µM 0.962618222578992 0.200696041088471 no 651 0.16786957465048 834 870624 SGTC_3134 9127454 49.47 µM 0.962431634493816 0.200742151029484 no 652 0.167916414661866 865 24262820 SGTC_984 1492-0255 2.91 µM 0.962140576820524 0.200814090353851 no 653 0.167989496919927 794 1585198 SGTC_3000 9075062 71.4286 µM 0.960343439342045 0.201258622768934 no 654 0.168441197147201 800 17057871 SGTC_2478 5763493 32.33 µM 0.959574896115001 0.201448906365922 no 655 0.168634604281855 862 1365576 YLR208W SEC13 SGTC_2403 6032726 181.2 µM 0.957683992038201 0.201917533982651 no 656 0.169111065623691 805 2881040 SGTC_52 0329-0193 875 nM 0.957054221782262 0.202073756321054 no 657 0.169269943962046 819 3739292 SGTC_1718 roemerine 11.9335 µM 0.95579944253745 0.202385235453371 no 658 0.169586785020139 850 235224 An aporphine alkaloid with mutagenic activity. SGTC_982 1491-0518 27.5 µM 0.95565276406343 0.202421664801725 no 659 0.169623847243557 793 3091256 SGTC_837 0091-0265 12.5 µM 0.955110685066064 0.202556330603838 no 660 0.169760863021728 866 759367 SGTC_2900 5328528 85.29 µM 0.954369432468579 0.202740562704208 no 661 0.169948336733062 904 795359 SGTC_2987 9018338 71.43 µM 0.953559625938385 0.202941947707927 no 662 0.170153300387987 860 5055682 SGTC_88 0180-0332 8.668 µM 0.952518364852705 0.203201066991473 no 663 0.170417078334947 870 3101745 SGTC_165 k038-0023 64.381 µM 0.952039332395837 0.203320341185175 no 664 0.170538517363947 858 46368543 SGTC_601 0986-0029 62.9 µM 0.951485665951109 0.20345825051642 no 665 0.170678945793146 878 24747981 SGTC_2653 dihydrofissinolide 100 µM 0.951325782683176 0.203498085226587 no 666 0.170719511336245 850 6857746 SGTC_1308 1187-1617 41.4 µM 0.947734410819532 0.204394096234641 no 667 0.171632339137141 880 2882570 SGTC_231 b-estradiol 524 µM 0.943837564526978 0.205368971804027 no 668 0.172626330676456 791 450 A steroid. SGTC_3138 9097216 49.47 µM 0.943698182434016 0.205403892157105 no 669 0.172661951542797 939 25237486 SGTC_2072 5231554 129 µM 0.943389886384838 0.205481144209033 no 670 0.172740757162778 945 789545 SGTC_1558 st069300 45.6 µM 0.942530855877949 0.205696488910821 no 671 0.172960460631651 802 24208000 SGTC_952 1185-0122 232 µM 0.942507032663996 0.205702462903635 no 672 0.172966556132712 844 678600 SGTC_412 gemfibrozil 100 µM 0.940165596462144 0.206290111925386 no 673 0.173566312905161 822 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_379 3970-0972 5.9 µM 0.937749900116902 0.206897440225676 no 674 0.17418647660657 851 2898042 YBL034C STU1 SGTC_627 1391-0720 175 µM 0.937699521917942 0.206910117023062 no 675 0.174199424798656 839 997839 SGTC_2600 tangeritin 87.95 µM 0.937102475647785 0.207060388334197 no 676 0.174352924061328 807 68077 A bioactive flavone. SGTC_2117 5521686 200 µM 0.933927716804707 0.207860531162755 no 677 0.175170590208499 834 803312 SGTC_3341 9147222 25.867 µM 0.933207539951106 0.208042292988542 no 678 0.175356411240598 816 1939759 SGTC_2183 6420625 130.508 µM 0.932531972777104 0.208212881254466 no 679 0.175530835581128 918 2897619 SGTC_881 0833-0569 170 µM 0.931193191682363 0.208551182197252 no 680 0.17587681952503 837 5418700 SGTC_1778 st046819 58.9 µM 0.930923886909691 0.208619272826132 no 681 0.175946468653473 931 671715 SGTC_607 4491-0986 66.8 µM 0.929740862533905 0.20891854219235 no 682 0.176252635977806 911 698981 YDR232W HEM1 SGTC_1563 conessine 56.1 µM 0.929625224570164 0.208947808660006 no 683 0.17628258122122 992 441082 An anti-amoebic, histamine inhibitor. SGTC_2150 5556613 200 µM 0.928936123363607 0.209122261299685 no 684 0.176461095452994 908 743190 SGTC_244 nsc-207895 1.295 µM 0.926668367943991 0.209696970716797 no 685 0.177049372939736 772 42640 SGTC_1681 tripelennamine 100 µM 0.92643281524579 0.209756719220188 no 686 0.177110548521985 840 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1776 st049249 45.9 µM 0.925799592581048 0.209917387269663 no 687 0.177275069481274 904 1822314 SGTC_3053 9095903 49.47 µM 0.923289393511058 0.210555013191961 no 688 0.177928206873419 922 17174018 SGTC_1672 st016598 6.51 µM 0.92244313662069 0.210770230274016 no 689 0.178148738994298 850 4665860 YNL267W PIK1 SGTC_1674 st016616 23.6 µM 0.921508003203259 0.211008200125299 no 690 0.178392632382723 846 625830 SGTC_64 000l-0018 272.079 µM 0.920455631504191 0.211276192682333 no 691 0.178667354296345 932 6811119 SGTC_1480 1070-0044 41.2 µM 0.919362315262121 0.211554823083819 no 692 0.178953046774129 904 3124987 SGTC_3286 9117135 37.221 µM 0.916927813263721 0.212176025454635 no 693 0.179590234136641 839 3438150 SGTC_1843 st055809 45.5 µM 0.916663383535964 0.212243563100042 no 694 0.179659529633116 833 16413835 SGTC_2092 5303694 80.6725 µM 0.915019157251972 0.212663794649148 no 695 0.18009078656443 888 1963699 SGTC_2222 6885208 172.143 µM 0.913849270447172 0.212963090061734 no 696 0.180398026430987 881 609514 SGTC_2264 7948757 110.76 µM 0.913708104752466 0.212999221487372 no 697 0.180435122093965 855 2971411 SGTC_410 α-linolenic acid 100 µM 0.913189049804889 0.213132104594342 no 698 0.180571561016816 913 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2348 9022543 33.42 µM 0.912817143022287 0.213227346070984 no 699 0.180669360312681 907 3162678 YDL140C RPO21 SGTC_2232 chlorophetanol 41.5365 µM 0.912747150679422 0.213245273159962 no 700 0.180687769717977 1018 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_905 2-aminofluorene 215 µM 0.912657652278624 0.213268197602086 no 701 0.180711311325461 944 1539 An established DNA mutagen. YPR165W RHO1 SGTC_3019 9081971 49.47 µM 0.911887076856085 0.213465635002901 no 702 0.180914082589744 958 16451803 SGTC_3057 9095946 49.47 µM 0.911653088323586 0.213525608795546 no 703 0.180975683166438 911 24540043 SGTC_3196 9111891 49.47 µM 0.909224025124991 0.214148783793959 no 704 0.181615942427009 900 18891510 SGTC_2811 7967822 32.47 µM 0.907582587973994 0.214570492240963 no 705 0.182049398565939 892 2232244 SGTC_3008 9078912 71.4286 µM 0.906580461499292 0.214828189872801 no 706 0.182314348931602 873 16648731 SGTC_1775 st081588 35.1725 µM 0.905380941269031 0.215136883751916 no 707 0.18263180450687 932 1426443 YGL099W LSG1 SGTC_1074 carmofur 3.8 µM 0.90492778011644 0.215253570754693 no 708 0.1827518243471 967 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1954 st077032 68.9 µM 0.903379317592874 0.215652570120292 no 709 0.183162306489536 807 698907 SGTC_2992 9074591 71.4286 µM 0.902106963111943 0.215980744176302 no 710 0.183500025172713 873 17741321 SGTC_2291 7917025 104.35 µM 0.90201042507521 0.21600565570659 no 711 0.183525664915919 858 2964612 SGTC_1510 1123-0200 71.5 µM 0.89947342966933 0.21666092090206 no 712 0.184200271144165 968 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1666 st014829 29 µM 0.897393339356562 0.217199031590484 no 713 0.184754532729046 933 3858230 SGTC_2776 terbinafine 19.92 µM 0.895652210672715 0.217650047290049 no 714 0.185219270702929 904 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2377 9073351 62.6 µM 0.894466317264614 0.217957545983553 no 715 0.185536221837548 874 7337946 YHR072W ERG7 SGTC_2943 9068529 45.32 µM 0.892361509070228 0.218503932990796 no 716 0.186099597604482 1011 3270634 SGTC_795 0685-0265 78 µM 0.891580723033554 0.218706817565803 no 717 0.18630885318481 940 302754 SGTC_825 1988-2224 89.6 µM 0.891026635110034 0.218850861162613 no 718 0.186457440641803 904 1180859 SGTC_1965 Pectolinarigenin 58.4 µM 0.890299649321898 0.219039934956645 no 719 0.186652504693426 936 5320438 An anti-inflammatory. SGTC_3097 9117246 49.47 µM 0.888179721725467 0.219591819829126 no 720 0.187222042424066 934 16423892 SGTC_1455 4262-0120 131 µM 0.887943954246157 0.2196532469431 no 721 0.187285449826638 955 1529587 SGTC_1999 st074831 12.5 µM 0.887495949619729 0.219769997737314 no 722 0.187405972954587 926 17112523 SGTC_2760 etidronate 98.04 µM 0.886862728288305 0.219935077075977 no 723 0.187576405210072 897 3305 A chelator and antioxidant. SGTC_764 1951-2361 146 µM 0.885780558274993 0.220217360946259 no 724 0.187867894132899 874 5438930 SGTC_1448 4255-0083 152 µM 0.883930913035278 0.220700321312211 no 725 0.188366754253373 988 5399660 SGTC_747 3448-8087 38.7 µM 0.882506782557098 0.221072588646727 no 726 0.188751406779556 925 5168703 SGTC_1178 0988-0033 191 µM 0.880797285146133 0.221519925002505 no 727 0.18921377471901 925 5392207 SGTC_2371 9071574 200 µM 0.880087902275709 0.221705706063636 no 728 0.189405846138073 910 45596039 SGTC_2029 5175081 200 µM 0.878634476968768 0.222086623132038 no 729 0.189799747972162 985 1380876 SGTC_2939 9044578 71.43 µM 0.877690384936939 0.222334252971646 no 730 0.190055881905166 905 2653634 SGTC_1937 st074714 47.2 µM 0.877533914853204 0.222375309373922 no 731 0.190098353043924 962 17250970 SGTC_3173 9105693 49.47 µM 0.877471736345881 0.22239162567934 no 732 0.190115231959786 965 17096658 SGTC_948 3448-0295 75.3 µM 0.876839753529264 0.22255750346832 no 733 0.190286841634926 961 678569 SGTC_2203 7227154 166.4 µM 0.876076602950061 0.22275790311403 no 734 0.190494195609594 974 896304 SGTC_2259 7964009 200 µM 0.874763171611466 0.22310304449951 no 735 0.190851389875012 878 313134 SGTC_2844 9010103 25.97 µM 0.874351071013597 0.223211398358853 no 736 0.19096354734603 888 2480525 SGTC_2213 7173844 200 µM 0.874109804404198 0.22327484863454 no 737 0.191029229326776 974 892728 SGTC_714 4296-0578 26.1 µM 0.87220240082975 0.223776834544113 no 738 0.191548985005285 953 1589775 SGTC_2455 5377712 9.75 µM 0.871435815802619 0.223978763150186 no 739 0.191758118505141 842 2243908 SGTC_1704 st028805 70.8 µM 0.871313806373558 0.224010911590145 no 740 0.191791417018931 927 2876101 SGTC_1385 3091-4834 14.1 µM 0.870784487768441 0.224150412863463 no 741 0.191935918344983 892 4072814 SGTC_1045 1348-1485 165 µM 0.86986101548261 0.224393910943999 no 742 0.192188181145029 1063 6810614 SGTC_2734 clemastine 41.6 µM 0.869847103002421 0.224397580487782 no 743 0.192191983135422 871 26987 Clemastine is a selective histamine H1 antagonist. SGTC_901 1112-0062 60.1 µM 0.866477094871933 0.225287453703779 no 744 0.193114290994319 921 1908457 SGTC_3123 9126162 49.47 µM 0.865627442466308 0.225512125151448 no 745 0.193347250705338 959 25239884 SGTC_1387 3342-1166 1.8 µM 0.863881088199634 0.225974307185888 no 746 0.193826608405301 884 3418228 SGTC_1126 isoteolin 1.0172 µM 0.863123026797393 0.226175098769123 no 747 0.194034914362504 935 133323 SGTC_2251 lansoprazole 556 µM 0.862114322421201 0.22644243569388 no 748 0.19431230533319 794 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_3148 9097893 49.47 µM 0.861131318461639 0.226703132824297 no 749 0.194582860943957 931 17174100 SGTC_1857 st056007 79.3 µM 0.86060411512206 0.226843019300794 no 750 0.194728059356382 944 619834 SGTC_1063 disulfiram 1.84 µM 0.860587645465606 0.22684739009185 no 751 0.1947325963678 958 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1124 fisetin 1.16336 µM 0.860477411738732 0.226876645634172 no 752 0.194762964878874 909 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_3174 9107204 49.47 µM 0.860327047919988 0.226916554956143 no 753 0.19480439355428 934 3938802 SGTC_3317 9138495 8.753 µM 0.859638992502646 0.227099228020478 no 754 0.19499403695062 954 17020139 SGTC_2132 5317594 122.667 µM 0.859148734697789 0.227229438007445 no 755 0.195129231377694 907 794577 SGTC_2049 5262831 67.185 µM 0.858838358757188 0.227311894029118 no 756 0.195214850682695 952 763417 SGTC_209 4077-0173 175.592 µM 0.857943213874523 0.227549797091291 no 757 0.195461910299784 862 15993494 SGTC_2349 9023730 187.07 µM 0.856880230767578 0.227832488615181 no 758 0.195755539723839 957 4126287 SGTC_2082 5219693 150 µM 0.854317015108082 0.228514966690163 no 759 0.196464680992926 997 2834649 SGTC_2841 9004761 38.96 µM 0.853960426157697 0.228610002459286 no 760 0.196563458380441 928 2991039 SGTC_1419 3993-2473 62.6 µM 0.852697559840493 0.228946751829831 no 761 0.196913522219405 988 704026 SGTC_3172 9105863 49.47 µM 0.8516453682861 0.229227536203607 no 762 0.19720547550678 951 2348785 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.851048492208147 0.229386902386893 no 763 0.19737120802987 1043 66535 A nucleotide analog. SGTC_2926 9010726 65.15 µM 0.850990594920942 0.229402364292306 no 764 0.197387288650596 959 2994293 SGTC_2572 astragaloside iv 100 µM 0.850662064482574 0.22949011187439 no 765 0.19747855099242 945 45006101 An anti-inflammatory agent. SGTC_1960 st011366 51.8 µM 0.850047741101378 0.229654242686341 no 766 0.197649272087338 1025 3972846 SGTC_2507 purpurin 79.67 µM 0.848526388595741 0.230060990379584 no 767 0.198072441332248 1001 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1242 0402-0103 60.1 µM 0.84803828937659 0.230191573590652 no 768 0.19820832358251 922 432868 SGTC_3272 9137413 49.47 µM 0.847152757232852 0.230428589490906 no 769 0.198454991046198 985 17614870 SGTC_3221 9128209 49.47 µM 0.84714451621314 0.230430795870355 no 770 0.198457287474832 944 16460723 SGTC_2857 9024691 58.44 µM 0.846725555761529 0.23054298028463 no 771 0.198574055411169 957 16478292 SGTC_2136 5328288 199.296 µM 0.841650434313271 0.231904359774673 no 772 0.199991825005108 880 262395 SGTC_3279 9140807 49.47 µM 0.841417723995851 0.231966890485813 no 773 0.200056979811177 1000 45595718 SGTC_1696 st025591 34.7925 µM 0.840962353945505 0.232089278410389 no 774 0.200184512346277 990 2787147 SGTC_1922 5578187 25 µM 0.840843428696327 0.232121247376248 no 775 0.200217827013857 969 1350412 SGTC_2706 st078239 82.5 µM 0.840730729709119 0.2321515448874 no 776 0.200249400585958 1012 15434492 SGTC_414 piperonyl butoxide 100 µM 0.839996376245592 0.232349019203223 no 777 0.200455209159116 962 5794 A potent inhibitor of cytochrome P450. SGTC_3126 9127922 49.47 µM 0.839751093663153 0.232414998729664 no 778 0.200523979906031 969 45595682 SGTC_1227 3909-8010 46.6 µM 0.838663319653267 0.232707728886026 no 779 0.200829133665413 947 15982272 SGTC_919 tnp00227 403.569 nM 0.838569055174297 0.232733105983273 no 780 0.200855590839389 997 1269246 A methoxyflavone. YNL221C POP1 SGTC_1683 st010134 710 nM 0.83837807173394 0.232784525667301 no 781 0.200909200497079 976 3818134 SGTC_148 3253-0744 288.01 µM 0.837993843249022 0.232887993064414 no 782 0.201017080659489 1014 6893655 SGTC_2864 9034755 47.6 µM 0.837482054114433 0.233025850443236 no 783 0.201160830090562 1041 4930451 SGTC_1804 st050076 49.1 µM 0.837413644893425 0.233044280832203 no 784 0.201180049287922 970 3895976 SGTC_1836 st055642 81 µM 0.836900175053905 0.233182642534913 no 785 0.201324340982874 1024 8571 SGTC_1925 st057770 10.1 µM 0.834526593894036 0.233822829751371 no 786 0.201992153918001 914 5989122 SGTC_2907 7721985 69.9 µM 0.833343139843516 0.234142386982925 no 787 0.202325616403262 1015 3267881 SGTC_2497 7-hydroxyflavone 100 µM 0.832599033813628 0.234343434864294 no 788 0.202535452048371 932 5281894 SGTC_2043 5101342 149 µM 0.831611707172097 0.234610345251435 no 789 0.202814075910825 954 678451 SGTC_476 mead acid 10 µM 0.830667007599786 0.234865889307706 no 790 0.203080884659236 977 5312531 An omega 9 fatty acid. SGTC_1573 oleylamine 1.06 µM 0.830595513437787 0.234885234951829 no 791 0.2031010850736 988 5356789 An amine of the fatty acid oleic acid. SGTC_2448 5185112 27.17 µM 0.829151828483486 0.235276070829136 no 792 0.203509249624792 918 5718189 SGTC_2258 7960471 200 µM 0.829109358801394 0.235287573699121 no 793 0.203521264231737 898 2974708 SGTC_2984 9022109 38.96 µM 0.825831634959483 0.236176277907328 no 794 0.204449802991019 985 6459207 SGTC_1820 st053765 18.6 µM 0.823636751146635 0.236772418811966 no 795 0.20507299367731 1011 3690829 SGTC_1947 st076332 61.6 µM 0.822424240364859 0.237102097028953 no 796 0.20541774396926 1020 24208416 SGTC_2513 baicalein 25.65 µM 0.819188720520524 0.237983058891473 no 797 0.206339374643529 1017 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_840 0245-0196 390 µM 0.81883083555709 0.238080613299483 no 798 0.206441467684138 1050 3827528 SGTC_1833 st055984 71 µM 0.817986010502274 0.238310987636747 no 799 0.206682587712797 988 676288 SGTC_2098 5376439 882.5 nM 0.813600412918488 0.23950885078031 no 800 0.207936950635309 1065 2844116 SGTC_1187 1391-0724 117 µM 0.812690401646776 0.23975781852138 no 801 0.208197792858149 1027 6997986 SGTC_1887 st057648 70.8 µM 0.811157193196311 0.240177604427194 no 802 0.208637702414551 1018 688672 SGTC_1629 st005085 44.9 µM 0.8101378474079 0.240456918482145 no 803 0.208930477025609 1014 24207091 SGTC_1786 berberine 21.6 µM 0.809081687830693 0.240746506500915 no 804 0.209234080360666 969 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2878 9043973 25.97 µM 0.808391356631975 0.24093589068676 no 805 0.209432663045028 1011 6465167 SGTC_958 1222-0007 33 µM 0.80628602042031 0.24151396481358 no 806 0.210038974603813 1066 7312461 SGTC_1943 st076331 65.2 µM 0.805084416143847 0.241844233455483 no 807 0.210385484005024 1118 24208415 SGTC_520 3584-0023 682 µM 0.803298775170007 0.242335480662289 no 808 0.210901032863277 949 1340790 SGTC_928 2764-0428 58.7 µM 0.800275752319415 0.243168374779119 no 809 0.211775524277354 1046 662578 SGTC_2006 4011487 200 µM 0.799763753017001 0.243309592386256 no 810 0.211923843805887 1059 45595294 SGTC_3213 9129884 49.47 µM 0.799319467414497 0.243432169379964 no 811 0.212052596784627 1002 17190742 SGTC_1534 6-azauridine 81.6 µM 0.797986721016898 0.243800069970651 no 812 0.212439098037751 1109 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1755 st041960 45.185 µM 0.796585241785234 0.244187267541298 no 813 0.212845975685618 1030 2257073 SGTC_624 k048-0052 28 µM 0.792852393782938 0.245220186143011 no 814 0.213931913257083 1001 6835531 SGTC_761 k216-0224 480 µM 0.792369813482316 0.245353892500746 no 815 0.214072537672438 1099 1340404 SGTC_1432 4049-0298 68.4 µM 0.792310781771714 0.245370250841139 no 816 0.214089743268107 1052 741646 SGTC_1036 k216-0215 33.5 µM 0.790867700703124 0.245770326827863 no 817 0.214510599131893 1024 622330 SGTC_1745 st081495 74 µM 0.790831444261244 0.245780382976047 no 818 0.214521179042913 1065 13842402 YBL026W LSM2 SGTC_733 4069-0007 56.1 µM 0.790544671218512 0.245859930616077 no 819 0.214604872330169 1081 5717425 YNL287W SEC21 SGTC_2580 diallyl disulphide 81.36 µM 0.788522301028974 0.246421305659208 no 820 0.215195629648065 999 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_579 4491-1009 110 µM 0.787857582000723 0.246605970065861 no 821 0.215390007548628 1227 1271041 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.78725098030825 0.246774553663591 no 822 0.215567479570537 1094 5393153 SGTC_3171 9103192 49.47 µM 0.786859440046876 0.246883401260783 no 823 0.215682076597513 1123 13018434 SGTC_818 4072-2707 53.5 µM 0.786817982148892 0.246894927997665 no 824 0.21569421267096 1053 882871 SGTC_3203 9113543 49.47 µM 0.785545600729882 0.247248834298008 no 825 0.216066872528344 1032 17018012 SGTC_2438 5259590 200 µM 0.785146519168787 0.247359892621385 no 826 0.216183833822055 1090 1201127 SGTC_348 k064-0012 10.7 µM 0.784977827008383 0.247406845098228 no 827 0.216233284495485 1016 5066323 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.782008355041961 0.248234124382227 no 828 0.217104831710302 1141 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1125 tnp00248 1.32998 µM 0.781913852772822 0.248260476415049 no 829 0.217132601638866 1180 24207736 SGTC_3169 9102970 49.47 µM 0.779469613070824 0.248942572498665 no 830 0.21785156541236 1101 17027839 SGTC_220 paclitaxel 373.376 µM 0.778729588078607 0.249149282377275 no 831 0.218069511411756 999 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2865 9030313 51.95 µM 0.777922440814583 0.249374845450913 no 832 0.218307368945954 988 42562754 SGTC_1356 1502-0781 85.8 µM 0.777205543821 0.249575278426182 no 833 0.218518755981408 1016 567702 SGTC_664 1222-0054 14.9 µM 0.776828384531401 0.24968076050003 no 834 0.218630013933746 1092 6813991 SGTC_2822 7994718 71.43 µM 0.77677136521388 0.249696709445269 no 835 0.21864683685906 991 1018011 SGTC_614 0462-0418 107 µM 0.774168813544625 0.250425248030279 no 836 0.219415484052849 983 5188303 SGTC_343 4130-2827 29.8 µM 0.77407992310221 0.250450151228279 no 837 0.219441764673894 1078 1118244 SGTC_3037 9091026 49.47 µM 0.773439214792803 0.250629688373056 no 838 0.219631244739157 1139 25236398 YIL048W NEO1 SGTC_2317 5986382 200 µM 0.772600575484141 0.250864792060188 no 839 0.219879401906233 1102 877883 SGTC_1640 st009078 66.4 µM 0.771793379206781 0.251091191236645 no 840 0.220118406847664 1026 690618 SGTC_441 propafenone 146 µM 0.771633930839941 0.251135925456344 no 841 0.220165635966867 1083 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_392 N-ethylmaleimide 8.33 µM 0.770912290361485 0.251338438832933 no 842 0.220379460858151 1041 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2171 5739187 198.077 µM 0.770526631235019 0.251446701423968 no 843 0.220493781952689 1056 2262761 SGTC_2867 9039098 71.43 µM 0.770061103470079 0.251577417636362 no 844 0.220631823800257 1076 6463460 SGTC_1153 4055-0057 267 µM 0.770052731314189 0.25157976879466 no 845 0.220634306828953 1094 882706 SGTC_2133 5320837 200 µM 0.769792591558947 0.25165282980477 no 846 0.220711467510439 1038 2841355 SGTC_3029 9088683 49.47 µM 0.769655149452057 0.251691435346089 no 847 0.220752240785171 1117 25236615 SGTC_2715 st079500 56.4 µM 0.769484422505204 0.251739394482891 no 848 0.220802894274372 1027 28246688 SGTC_758 0868-0029 16 µM 0.768887771985049 0.251907038278283 no 849 0.220979968568129 1113 762687 SGTC_966 1300-0360 30.2 µM 0.76851055618339 0.252013056829804 no 850 0.221091960821638 1052 70588 SGTC_2726 cimetidine 79.27 µM 0.768475945231576 0.252022785605008 no 851 0.221102238153574 1104 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1699 st031318 29.054 µM 0.766371351127604 0.252614737101158 no 852 0.221727687137334 1118 5340658 SGTC_3285 9112818 20.8695 µM 0.766366547854839 0.252616088937307 no 853 0.221729115742122 1145 17017947 YPR165W RHO1 SGTC_2353 9059630 146.67 µM 0.766091920851414 0.252693386473077 no 854 0.221810804931448 1100 4779114 SGTC_2001 4023502 57.655 µM 0.765738865334087 0.252792777086343 no 855 0.221915848330325 1069 108941 YCR052W RSC6 SGTC_429 1112-0049 25.5 µM 0.765349058561443 0.252902537651418 no 856 0.222031859194909 1007 2836170 SGTC_188 3229-0966 278.469 µM 0.76450276491461 0.253140920670609 no 857 0.222283844816536 1198 5722370 SGTC_1953 st076800 12.1 µM 0.764044365561876 0.253270091399229 no 858 0.222420402235138 1009 297591 SGTC_2975 9084847 53.72 µM 0.763714547391006 0.253363051125255 no 859 0.222518684840623 1060 27211724 SGTC_989 1501-0895 10.3 µM 0.76330802045202 0.253477655999783 no 860 0.222639859978668 1099 2830112 SGTC_1386 3228-0095 33.8 µM 0.762568454786613 0.253686218364694 no 861 0.222860401758647 1070 870181 SGTC_455 paf C-16 10 µM 0.760084300296276 0.254387425411511 no 862 0.223602098212357 1076 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_3075 9116269 49.47 µM 0.759971866692655 0.254419186271658 no 863 0.223635700796738 1097 17015205 YNL244C SUI1 SGTC_3304 9125678 46.087 µM 0.759591457830295 0.254526661658902 no 864 0.223749413373132 1052 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1627 st003713 25.6 µM 0.758669488285125 0.254787240659396 no 865 0.224025146676378 1142 16195070 YER133W GLC7 SGTC_146 3448-8650 53.125 µM 0.757343457741127 0.255162265364414 no 866 0.224422060716742 1135 2891488 YIL048W NEO1 SGTC_1904 st060225 78 µM 0.755152209004519 0.255782621028905 no 867 0.225078830038294 1110 66595 SGTC_3052 9092717 49.47 µM 0.755089851611254 0.25580028629546 no 868 0.225097535954031 1103 25237534 SGTC_2821 7996764 71.43 µM 0.753461284423985 0.256261869566036 no 869 0.225586383895961 1182 2987135 SGTC_2036 5160441 105 µM 0.753207002019044 0.256333979760357 no 870 0.225662766179607 1124 134534 YIL048W NEO1 SGTC_123 0083-0120 66.675 µM 0.752411652099358 0.256559595815284 no 871 0.225901770751806 1078 16001701 SGTC_1300 1094-0077 113 µM 0.752257597164631 0.256603308366994 no 872 0.22594808117369 1052 5532636 SGTC_2587 piperic acid 92.2 µM 0.751593534989656 0.256791778084234 no 873 0.226147766191167 1068 5370536 SGTC_895 0964-0006 13.7 µM 0.749935283127828 0.257262726538852 no 874 0.226646841522532 1100 6738897 SGTC_2727 riluzole 51.77 µM 0.748870259333428 0.257565433058537 no 875 0.226967703678219 1113 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_3006 9075424 71.4286 µM 0.748477250064972 0.257677182873277 no 876 0.227086171154831 1100 7465181 SGTC_311 1315-0136 58 µM 0.747334237001296 0.258002334752425 no 877 0.227430915472897 1108 6759207 SGTC_1072 oxiconazole 14.9 nM 0.747035525711651 0.258087343941793 no 878 0.22752105838851 1104 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_76 0433-0009 400.328 µM 0.746453438697993 0.258253039746017 no 879 0.227696774158129 1004 2841569 SGTC_1018 4259-0013 28.1 µM 0.746130191649481 0.258345078454199 no 880 0.22779438637077 1092 6801262 SGTC_3110 9122132 49.47 µM 0.746051239586437 0.258367561198274 no 881 0.227818231421043 1153 918317 SGTC_2816 7982706 58.44 µM 0.745414053188204 0.258549046358929 no 882 0.228010725443486 1099 2981853 SGTC_2393 9031399 185.94 µM 0.745326262421235 0.258574056337228 no 883 0.228037254204504 1134 1526623 YDL150W RPC53 SGTC_2334 9017922 200 µM 0.745234499936335 0.258600199124087 no 884 0.228064985001381 1127 3163164 SGTC_2966 9084041 48.03 µM 0.745143735516119 0.258626058912357 no 885 0.228092416046815 1079 17741380 SGTC_1848 st056003 16.4 µM 0.745048029481407 0.258653328071461 no 886 0.228121342568646 1191 146492 SGTC_3112 9123419 49.47 µM 0.744646221629216 0.258767829906902 no 887 0.228242808866247 1175 17015854 SGTC_1557 sumaresinolic acid 42.3 µM 0.742082892031239 0.259498910354868 no 888 0.229018557256882 1086 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2830 7992007 71.43 µM 0.739219961176338 0.260316698456504 no 889 0.229886720876091 1054 1952075 SGTC_2244 6635614 200 µM 0.73757697441488 0.260786611901534 no 890 0.230385775884759 990 836499 SGTC_3094 9117742 49.47 µM 0.736287251656461 0.261155793228823 no 891 0.230777951416186 1145 17149698 SGTC_2339 9000433 200 µM 0.735771785036149 0.26130341991693 no 892 0.230934797393105 1103 2988954 SGTC_2417 cerulenin 830 nM 0.734101980516832 0.261781936562782 no 893 0.231443293290191 1134 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2680 butyl paraben 22.24 µM 0.733688469705403 0.261900505951487 no 894 0.231569313718475 1161 7184 An antifungal and steroid mimetic. SGTC_1675 st018485 24.5 µM 0.73261810954286 0.262207547061106 no 895 0.231895691334702 1127 3323024 SGTC_1572 epiandrosterone 68.9 µM 0.732510146957377 0.262238527201626 no 896 0.231928625846604 1114 441302 A steroid. SGTC_1594 piperine 70.1 µM 0.732278066838475 0.262305129533767 no 897 0.23199943183323 1129 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1807 st050092 58.9 µM 0.731480230097515 0.262534158721712 no 898 0.232242937910879 1128 5008496 SGTC_2818 7996756 12.99 µM 0.72977128816006 0.263025076443942 no 899 0.232764998743187 1142 2241621 SGTC_1464 k208-0027 110 µM 0.728662279973436 0.263343905557306 no 900 0.233104135776251 1132 X1464 SGTC_2875 9039966 71.43 µM 0.727787285432658 0.263595597211019 no 901 0.233371904445138 1178 6463691 SGTC_172 1112-0046 2.638 µM 0.726880381178111 0.263856597147362 no 902 0.23364961824316 1063 2802135 YIL048W NEO1 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.725235812762866 0.264330226909486 no 903 0.234153687917193 1141 616764 SGTC_1184 1269-1718 139 µM 0.724938967247552 0.264415763436879 no 904 0.234244736883811 1165 5403821 SGTC_3163 9099914 49.47 µM 0.724457830037752 0.26455443383836 no 905 0.234392353733968 1146 16268368 SGTC_684 1140-0066 328 µM 0.723521379790258 0.264824437805174 no 906 0.234679811908528 1173 6813534 SGTC_2812 7970281 58.44 µM 0.723494147082011 0.264832291828092 no 907 0.234688174333762 1163 2233435 SGTC_2798 7813637 45.45 µM 0.723347057792147 0.264874715019513 no 908 0.234733344308878 1127 956368 SGTC_3250 9135583 49.47 µM 0.720860336148177 0.265592452619122 no 909 0.235497724258665 1144 7699353 SGTC_1305 1181-0477 144 µM 0.720520070124876 0.265690739601032 no 910 0.235602423514806 1139 6252086 SGTC_1497 4476-2978 41.3 µM 0.71829488055215 0.266333947394548 no 911 0.236287743048243 1207 1528379 SGTC_1203 3992-3522 103 µM 0.718050537656834 0.266404624531676 no 912 0.236363063220666 1241 5322312 SGTC_46 0329-0187a 2.197 µM 0.717681431704974 0.266511407861538 no 913 0.236476867419008 1178 46494817 SGTC_2636 apigenin dimethyl ether 100 µM 0.717404754024068 0.266591465640905 no 914 0.236562193540803 1164 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2508 celastrol 40.54 µM 0.717168105213614 0.266659950555879 no 915 0.236635188383038 1122 122724 Celastrol is a natural product and antioxidant. SGTC_2409 alverine citrate 63.97 µM 0.716768241998298 0.266775689064457 no 916 0.236758555217331 1171 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1737 st035557 69.7 µM 0.715689727084083 0.267087986613322 no 917 0.237091477726747 1039 5716916 SGTC_3062 9077494 49.47 µM 0.71516361477732 0.267240395998765 no 918 0.237253974557956 1126 16459633 SGTC_3240 9133527 49.47 µM 0.712205777406898 0.26809806761044 no 919 0.238168679940744 1144 17617455 SGTC_2666 tannic acid 100 µM 0.711919632802705 0.268181113193918 no 920 0.238257271989394 1196 16134267 A thiamine antagonist. SGTC_843 0310-0051 143 µM 0.71184536066289 0.26820267075095 no 921 0.238280270030308 1200 2065037 SGTC_195 4234-0266 16.654 µM 0.708914270357561 0.269054118012026 no 922 0.239188839452486 1169 2303354 SGTC_960 1222-0186 7.7 µM 0.707974238119449 0.26932747333803 no 923 0.239480627883494 1169 3126296 SGTC_3239 9133757 49.47 µM 0.707829752284309 0.269369501233656 no 924 0.23952549388598 1169 17036923 SGTC_2675 theaflavin digallate 100 µM 0.707802311527187 0.269377483545262 no 925 0.239534015357961 1155 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1225 1216-0074 20.6 µM 0.706956789543978 0.269623497695464 no 926 0.239796665452121 1168 4241466 SGTC_2328 6201408 200 µM 0.706839943825829 0.269657504124421 no 927 0.239832974364544 1135 2890418 SGTC_2137 5261020 140 µM 0.705738701024315 0.269978112053876 no 928 0.24017532442377 1184 763655 SGTC_792 4534-1957 155 µM 0.704943750363099 0.270209666782619 no 929 0.240422621013049 1149 1717904 SGTC_2482 5981709 142.65 µM 0.704547799903042 0.270325037022192 no 930 0.240545846667338 1154 877755 SGTC_160 3453-0671 289.699 µM 0.704262337666985 0.270408228980727 no 931 0.240634708077064 1176 5322268 SGTC_983 1491-0821 12.2 µM 0.702711841313593 0.270860311872315 no 932 0.241117673353826 1155 46495113 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.697376105152161 0.272418945489207 no 933 0.242783725664193 1192 5379071 SGTC_1842 st055362 61.2 µM 0.694885144847533 0.273148107541335 no 934 0.243563641483296 1196 676032 SGTC_1648 st011736 69.8 µM 0.694658815969021 0.273214407169317 no 935 0.243634571702769 1213 2855514 SGTC_751 0833-0568 350 µM 0.694190219275274 0.273351700832925 no 936 0.243781462763294 1224 6954252 SGTC_2517 totarol 10 µM 0.693874684725963 0.273444168220974 no 937 0.243880400341188 1162 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_471 1-acyl-paf 4 µM 0.693469590381851 0.273562903801468 no 938 0.24400745164024 1157 16759367 SGTC_3135 9127742 49.47 µM 0.691331914297921 0.27418989173578 no 939 0.244678490160535 1176 3643468 SGTC_2484 5809818 12.04 µM 0.691310247929579 0.274196250189572 no 940 0.244685296539534 1198 2870548 SGTC_2059 5238311 157 µM 0.69077293647752 0.274353958887013 no 941 0.244854122798225 1213 703021 SGTC_981 1488-1094 54.9 µM 0.689797934416376 0.274640250423534 no 942 0.245160633919618 1185 3449522 SGTC_3003 9075612 71.4286 µM 0.689472112672903 0.274735954860429 no 943 0.245263108386534 1200 6501993 SGTC_2735 sertaconazole 140 nM 0.689180929224481 0.27482149881637 no 944 0.245354708216388 1249 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1364 1653-0028 37.6 µM 0.685190900142068 0.275995011535955 no 945 0.246611732685539 1180 5718652 SGTC_2268 7933382 153.85 µM 0.685150049922263 0.276007038762786 no 946 0.24662462001194 1254 935025 YOR257W CDC31 SGTC_1360 1598-0022 39.8 µM 0.685069875679991 0.276030644617764 no 947 0.246649914232435 1227 761525 SGTC_2924 9010168 62.78 µM 0.683880527859032 0.276380942953252 no 948 0.247025305428153 1235 2993929 SGTC_834 0312-0008 75.7 µM 0.683502910392051 0.27649220812512 no 949 0.247144555886259 1231 6385573 YIL048W NEO1 SGTC_2470 5664817 21.68 µM 0.683403601457077 0.276521473198588 no 950 0.247175922461296 1245 2859561 SGTC_225 nsc-122657 1.016 µM 0.682768385538114 0.276708699123737 no 951 0.247376604787575 1155 275685 SGTC_1761 st044296 37 µM 0.682745328372005 0.276715496247488 no 952 0.247383890823426 1232 1826700 SGTC_261 5-fluorouridine 15.376 µM 0.682687627202707 0.276732506588349 no 953 0.247402124823927 1235 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_44 0929-0055 61.211 µM 0.682648119336594 0.276744153827505 no 954 0.247414610019002 1181 1379590 SGTC_1555 citronellol 128 µM 0.680485347587403 0.277382122648608 no 955 0.248098598209164 1196 8842 A terpine precursor. SGTC_2877 9040724 71.43 µM 0.680289130649617 0.277440037771789 no 956 0.248160702739649 1209 6463895 SGTC_1722 st034304 3.6505 µM 0.679093247021255 0.27779314089137 no 957 0.248539390497541 1241 4036148 YLR033W RSC58 SGTC_1409 3909-8004 61.9 µM 0.678734742488277 0.277899037629085 no 958 0.248652974271592 1234 2119279 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.675645462267633 0.278812379185344 no 959 0.249632884965235 1284 5024745 SGTC_635 k038-0028 24.7 µM 0.673478250899452 0.27945398302528 no 960 0.250321540397273 1254 4035102 SGTC_1440 4100-1550 40 µM 0.673383990892154 0.279481905004212 no 961 0.250351515398092 1244 742806 SGTC_2442 5158906 48.48 µM 0.672154613366443 0.279846198872644 no 962 0.250742635785582 1248 1893835 SGTC_1206 3978-0017 132 µM 0.671743906256231 0.279967952485004 no 963 0.250873372291486 1281 3873677 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.671333406184849 0.280089670379275 no 964 0.251004078939278 1222 15053 SGTC_1569 carminic acid 40.6 µM 0.671283077408536 0.280104595193048 no 965 0.251020106521008 1241 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1044 1222-0021 1.78 µM 0.669240958644043 0.280710502882502 no 966 0.251670891271153 1211 4306703 SGTC_2558 carylophyllene oxide 100 µM 0.66922770360805 0.280714437793274 no 967 0.251675118310064 1312 6708694 An oxygenated terpenoid and antifungal agent. SGTC_927 2425-1185 123 µM 0.668770061576403 0.28085031048343 no 968 0.251821083621087 1224 730375 SGTC_3056 9094900 49.47 µM 0.66842160877272 0.280953786501446 no 969 0.251932252898634 1180 25236784 SGTC_2293 7624732 200 µM 0.668143830977559 0.281036288172198 no 970 0.252020892795925 1215 894453 SGTC_909 3448-9333 149 µM 0.663976528535759 0.28227540498952 no 971 0.253352666828767 1209 3344074 SGTC_2306 7482397 179.52 µM 0.663219535697521 0.282500773093519 no 972 0.25359498074789 1273 891448 SGTC_1414 3917-0015 5.4 µM 0.663045261016413 0.282552669525295 no 973 0.253650783425762 1227 6618702 SGTC_757 1066-0008 322 µM 0.662633637720219 0.282675263070948 no 974 0.253782610628717 1273 6842497 SGTC_2031 5180455 200 µM 0.660830511012317 0.283212588357801 no 975 0.254360506800192 1219 29949 SGTC_3267 9137951 49.47 µM 0.660186416215297 0.283404644995333 no 976 0.254567104135219 1247 16643986 SGTC_2333 9017922 200 µM 0.659652879402192 0.283563782642607 no 977 0.254738305863831 1281 3163164 SGTC_1983 st071813 46.9 µM 0.658908884260768 0.283785765002002 no 978 0.254977140238253 1258 11838595 SGTC_2472 5377652 49.4 µM 0.658270385486777 0.283976337220266 no 979 0.255182201968902 1245 1610903 SGTC_2383 9036125 200 µM 0.656031954932223 0.284644923006217 no 980 0.255901782014558 1205 79580 SGTC_2100 5377183 190 µM 0.654678360986188 0.285049585601309 no 981 0.25633743008872 1282 2844202 SGTC_1829 berberine 14.4 µM 0.65445409899286 0.285116656143026 no 982 0.25640964510257 1306 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.654331199427551 0.285153415184641 no 983 0.256449224712163 1265 688761 SGTC_21 0849-0113 22.993 µM 0.654260348381596 0.285174607632986 no 984 0.256472043625303 1234 1560156 SGTC_2465 5809242 33.21 µM 0.651999214697974 0.285851335369044 no 985 0.257200839499825 1266 2731748 SGTC_3189 9110682 49.47 µM 0.651849937714891 0.285896038874261 no 986 0.257248991475392 1299 17122418 SGTC_3 0833-0587 95.581 µM 0.651559524325035 0.285983017573891 no 987 0.257342682961965 1197 5382644 SGTC_2471 5466956 24.79 µM 0.647835945931202 0.287099340772922 no 988 0.258545531708879 1246 724419 SGTC_2851 9015922 71.43 µM 0.647001047045108 0.287349925093711 no 989 0.258815632912812 1277 2996893 SGTC_1911 st060208 74.3 µM 0.646981221078201 0.287355876863967 no 990 0.258822048658557 1299 688783 SGTC_224 benfluorex 43.875 µM 0.646675680512733 0.287447607746967 no 991 0.258920932960138 1274 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_3274 9138298 49.47 µM 0.644850308282479 0.28799591823406 no 992 0.259512098258165 1244 17015756 SGTC_524 r073-0010 27.8 µM 0.644798768999953 0.288011406914322 no 993 0.259528799889649 1228 2772106 SGTC_2719 novobiocin 32.65 µM 0.644306021429527 0.288159508169494 no 994 0.259688505882656 1301 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.64413782537261 0.28821006975745 no 995 0.259743032055783 1233 6708514 SGTC_721 1187-1332 279 µM 0.643949505940887 0.28826668561902 no 996 0.2598040888797 1222 25730 SGTC_237 nikkomycin 200 µM 0.643402190253734 0.288431258943586 no 997 0.259981581302813 1321 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_3147 9097027 49.47 µM 0.642600035263927 0.288672540337177 no 998 0.26024183009822 1310 25236841 SGTC_2956 9076196 2.52 µM 0.6421575510348 0.288805676495653 no 999 0.260385445804879 1318 16423868 SGTC_1706 st031321 9.9705 µM 0.642029943272095 0.288844076922274 no 1000 0.260426870635796 1295 6103185 SGTC_1035 k081-0041 55.2 µM 0.641807509884922 0.28891101854004 no 1001 0.260499086468624 1297 731709 SGTC_2271 7849410 118.62 µM 0.641595401200407 0.288974859724571 no 1002 0.260567959858711 1278 972430 SGTC_1127 asiatic acid 681.4 nM 0.641132807643258 0.289114115705035 no 1003 0.260718200205929 1267 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1159 4092-0538 61.2 µM 0.640423369042912 0.289327741506785 no 1004 0.260948697040327 1312 717301 SGTC_1575 cyproterone acetate 48 µM 0.639812724681004 0.289511677814931 no 1005 0.261147179480043 1232 9880 An androgen receptor antagonist and liver toxin. SGTC_707 0865-0008 204 µM 0.639507052300599 0.289603772074784 no 1006 0.261246563660846 1301 723043 SGTC_2079 5212404 121 µM 0.637863131572206 0.290099295145324 no 1007 0.261781389645955 1305 758462 SGTC_2037 5169046 200 µM 0.636882284882165 0.290395138550689 no 1008 0.2621007613454 1305 5718022 SGTC_880 0833-0487 87.2 µM 0.636706674826134 0.290448121037402 no 1009 0.262157962484213 1261 76075 SGTC_638 3970-0837 4.09 µM 0.635576089305746 0.290789332988242 no 1010 0.262526379113745 1276 4118451 YLR208W SEC13 SGTC_3247 9135149 49.47 µM 0.634974087396831 0.290971094257576 no 1011 0.262722657669892 1255 8934436 YOR116C RPO31 SGTC_3212 9128307 49.47 µM 0.634196644604337 0.291205904567913 no 1012 0.262976248540045 1235 27243542 SGTC_2972 9093619 59.92 µM 0.633583870731403 0.291391042402431 no 1013 0.263176214871574 1267 25236256 SGTC_142 0335-0849 62.6745 µM 0.633402106442687 0.291445969543816 no 1014 0.263235544897272 1328 3889043 YPR107C YTH1 SGTC_2099 5377090 177.372 µM 0.629689355945579 0.292568976756932 no 1015 0.264448923973003 1292 2243829 SGTC_1711 st032263 62.8 µM 0.629581677314596 0.292601576630048 no 1016 0.264484157291273 1312 3958979 SGTC_2111 5486399 200 µM 0.62913872005014 0.292735700379204 no 1017 0.264629121609205 1300 689674 SGTC_445 e6 berbamine 66 µM 0.623781828897646 0.294359977831327 no 1018 0.266385437375793 1333 6610268 A calcium/calmodulin antagonist. SGTC_827 3253-0474 693 µM 0.622287087893401 0.294813943774734 no 1019 0.26687655500568 1317 5402065 SGTC_2200 6600604 21.907 µM 0.62199190899653 0.294903630340415 no 1020 0.266973594134729 1269 2904777 SGTC_1462 k081-0014 26.5 µM 0.618930996662237 0.295834392142038 no 1021 0.267980908796588 1124 3270634 SGTC_2040 5100729 123 µM 0.618668276534912 0.295914342881483 no 1022 0.268067456373151 1332 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1581 himbacine 57.9 µM 0.618411166307478 0.29599259602659 no 1023 0.268152169508041 1303 5281825 An alkaloid muscarinic receptor antagonist. SGTC_908 3448-7491 47.7 µM 0.617138129922264 0.296380192697978 no 1024 0.268571810199044 1316 1203031 SGTC_3320 9137005 35.139 µM 0.616126552582837 0.296688349706492 no 1025 0.268905499336049 1307 4908713 SGTC_1889 st059080 5.18 µM 0.61490073494373 0.297061967276474 no 1026 0.269310138722201 1321 176925 Isolated from Daphnopsis sellowiana. SGTC_2418 pentamidine 31.67 µM 0.614766206337409 0.297102983416696 no 1027 0.269354564870905 1281 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1981 st071826 47 µM 0.612998021565507 0.297642322021458 no 1028 0.269938823946724 1285 11838600 SGTC_3352 9151559 45.5865 µM 0.611105464777335 0.298220091610543 no 1029 0.270564881119425 1278 17159339 SGTC_1319 1306-0155 43.7 µM 0.610839412716305 0.298301354299864 no 1030 0.27065294916953 1348 3122360 SGTC_347 4534-1311 26.2 µM 0.61061282620172 0.29837057061816 no 1031 0.270727964695406 1319 2862016 SGTC_1129 3453-1384 223 µM 0.61057757343003 0.29838134008501 no 1032 0.270739636690296 1398 1084452 SGTC_1 0258-0098 57.368 µM 0.610126377399218 0.298519192830166 no 1033 0.270889047346633 1252 6790032 YDR047W HEM12 SGTC_2560 caryophyllene 100 µM 0.610083553068811 0.29853227834133 no 1034 0.270903230485296 1349 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2157 5649910 96.377 µM 0.609087764837858 0.298836627467332 no 1035 0.271233133500678 1299 2858091 SGTC_2757 clomiphene 4.22 µM 0.608958469670817 0.298876155115628 no 1036 0.271275983464249 1388 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1982 st072467 71.9 µM 0.608779276795752 0.298930941236776 no 1037 0.271335375702795 1317 3163533 SGTC_811 0416-0114 265 µM 0.608504225820682 0.299015043722065 no 1038 0.271426552050534 1334 6612453 SGTC_222 nsc-310342 10.666 µM 0.606976458680005 0.299482385368787 no 1039 0.27193326760365 1306 432556 SGTC_1740 st038286 13.222 µM 0.606756857538453 0.299549588233711 no 1040 0.272006141522079 1361 716786 SGTC_598 3937-0236 20.2 µM 0.605438458546046 0.299953191440524 no 1041 0.272443851977167 1354 1379313 SGTC_256 clotrimazole 625 nM 0.60420764964495 0.300330202536395 no 1042 0.27285279786298 1329 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_132 0417-1715 25.805 µM 0.604144177774501 0.300349650514568 no 1043 0.272873895140866 1380 6769098 SGTC_1621 st003705 32.4 µM 0.604031398489251 0.300384207841596 no 1044 0.272911383599633 1356 24207032 SGTC_2645 abamectin 100 µM 0.603420525243373 0.300571420115888 no 1045 0.273114485621281 1301 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2571 chrysanthemic acid 100 µM 0.603400645425565 0.300577513502006 no 1046 0.273121096485148 1278 2743 An insecticide. SGTC_1055 3448-0672 86 µM 0.603357637497304 0.300590696103054 no 1047 0.273135398676249 1330 748378 SGTC_374 0880-0231 82.3 µM 0.601712474008233 0.301095160219728 no 1048 0.273682772618093 1315 6833587 SGTC_2475 5812728 15.03 µM 0.599223254882482 0.301859165474152 no 1049 0.274512008630359 1332 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1471 k673-0312 37 µM 0.597915633381206 0.302260856789636 no 1050 0.274948113983315 1342 24099884 SGTC_2446 5162541 200 µM 0.596957126106022 0.302555455145823 no 1051 0.275268002797867 1310 1549321 SGTC_1347 1493-0251 600 nM 0.596731816063062 0.302624723134166 no 1052 0.275343223555595 1366 3986378 SGTC_53 0973-0023 39.979 µM 0.596538766506472 0.302684078801455 no 1053 0.275407682052396 1327 674768 SGTC_1509 1326-1131 80 µM 0.59576683706887 0.302921470933446 no 1054 0.275665500465779 1317 768313 SGTC_3167 9103034 49.47 µM 0.594972471182668 0.30316584993489 no 1055 0.275930936293047 1355 5127859 SGTC_177 1327-0068 8.361 µM 0.59488476677964 0.303192836752111 no 1056 0.275960250243852 1335 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_3182 9108849 49.47 µM 0.594452203597426 0.303325953004728 no 1057 0.276104850713824 1356 17133045 SGTC_2431 5490079 200 µM 0.593149336158061 0.303727052925499 no 1058 0.276540607640759 1353 5722345 SGTC_2788 5282734 71.43 µM 0.592699234054334 0.303865676056055 no 1059 0.276691227068843 1449 743706 SGTC_1054 3429-0080 167 µM 0.59073532817519 0.304470852674081 no 1060 0.277348886527089 1391 1162877 SGTC_2695 st077686 51.995 µM 0.590623261442743 0.304505402153529 no 1061 0.27738643771342 1313 2876092 SGTC_1298 1079-1278 263 µM 0.589570545244914 0.304830033157787 no 1062 0.277739301891098 1378 2840950 SGTC_258 haloperidol 50.781 µM 0.588999439645216 0.305006211985849 no 1063 0.277930824753518 1300 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2627 acetyl isogambogic acid 100 µM 0.588419066450932 0.305185296063758 no 1064 0.278125521558123 1292 6857789 A caspase activator and apoptosis inducer. SGTC_3049 9092223 49.47 µM 0.587543825439899 0.305455454868146 no 1065 0.27841926291603 1340 8623917 SGTC_318 1488-0629 67.2 µM 0.58656021025732 0.305759191773295 no 1066 0.278749556250015 1349 3662576 SGTC_2729 fluphenazine 10.66 µM 0.585804593199416 0.305992614463143 no 1067 0.279003418363117 1278 3372 An atypical antipsychotic. SGTC_1267 0828-0272 9.49 µM 0.585000509509849 0.306241095860687 no 1068 0.279273687085136 1439 745334 SGTC_831 k061-1017 217 µM 0.581339835439514 0.307373458599228 no 1069 0.280505718884531 1409 1240153 SGTC_296 1222-0039 74.9 µM 0.578622815858795 0.308215108612341 no 1070 0.281421853129668 1325 5984176 SGTC_377 3970-0964 33.1 µM 0.578075264051001 0.308384845847198 no 1071 0.281606653236222 1403 16481235 SGTC_1665 st014639 11.4 µM 0.576666847870795 0.308821633181683 no 1072 0.282082265913187 1433 981133 YIL048W NEO1 SGTC_1645 Cervolide 78 µM 0.57583306780278 0.309080338100164 no 1073 0.282364009981775 1325 23173 A fragrance. SGTC_2552 juarezic acid 87.02 µM 0.575371431032487 0.309223615303717 no 1074 0.282520060666484 1392 1549512 SGTC_2929 9013348 24.6 µM 0.574735620219669 0.309420998030014 no 1075 0.282735056625316 1382 2995952 SGTC_2684 capsaicin 100 µM 0.572980888705744 0.309966026555189 no 1076 0.283328817026703 1361 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_403 arphamenine a 50 µM 0.571266614316455 0.310498892489318 no 1077 0.28390946447107 1356 5487158 An arginine aminopeptidase inhibitor. SGTC_2459 5811157 9.22 µM 0.570520385352946 0.310730975061778 no 1078 0.284162399899305 1345 2870684 YBR192W RIM2 SGTC_2058 5236698 133 µM 0.567651804070972 0.311623825203134 no 1079 0.285135711816109 1383 766665 SGTC_1624 st003710 6.25 µM 0.567152451922671 0.311779362733871 no 1080 0.285305304642832 1455 24207033 SGTC_701 4424-0219 185 µM 0.564264026414232 0.312679703772491 no 1081 0.286287229858534 1443 2911779 SGTC_2836 9010338 19.48 µM 0.563601559483993 0.312886356958017 no 1082 0.286512662633001 1260 2994051 SGTC_2952 9073731 13.78 µM 0.561661974314982 0.313491738657847 no 1083 0.287173173453353 1367 16457353 SGTC_6 0844-0013 19.835 µM 0.560287600602311 0.313921011488583 no 1084 0.287641641774333 1480 1584900 SGTC_1548 st061468 90.8 µM 0.559136785257877 0.314280651800416 no 1085 0.288034185731895 1394 390799 SGTC_1172 0370-0043 85 µM 0.558968471440456 0.314333266199054 no 1086 0.288091618886511 1443 376585 SGTC_481 bay k-8644 50 µM 0.557700921944709 0.314729619514136 no 1087 0.28852431401491 1348 2303 A calcium channel antagonist. SGTC_736 0958-0254 92.6 µM 0.557662316216955 0.314741694591756 no 1088 0.288537497405195 1446 6812352 SGTC_2242 6630449 61.2675 µM 0.556014639168834 0.315257238593507 no 1089 0.289100423623707 1419 691249 YDR170C SEC7 SGTC_1003 4049-0218 100 µM 0.555519738145455 0.315412159218756 no 1090 0.289269606572316 1464 295161 SGTC_541 4513-1321 94 µM 0.555488001798073 0.315422094867946 no 1091 0.289280457296482 1336 747515 SGTC_3166 9102297 49.47 µM 0.555239276162701 0.315499967639241 no 1092 0.289365503740055 1344 25237072 SGTC_493 zm226600 134 µM 0.554753404190594 0.315652111490268 no 1093 0.289531671212261 1430 5240098 A potassium channel opener. YCR052W RSC6 SGTC_3143 9086658 49.47 µM 0.552693898553517 0.316297362895207 no 1094 0.290236516024565 1449 25236626 SGTC_3015 9080845 49.47 µM 0.551981967389043 0.316520544086537 no 1095 0.290480354027803 1496 5296973 SGTC_483 fpl-64176 144 µM 0.550999153940716 0.316828753156284 no 1096 0.290817127273949 1425 3423 SGTC_2423 st077119 87.2 µM 0.550786658635674 0.3168954081463 no 1097 0.290889965424399 1351 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1721 st082152 9.2685 µM 0.549953181508178 0.317156908503541 no 1098 0.291175743109138 1351 5296051 SGTC_613 3914-0030 117 µM 0.549607973004367 0.317265243144679 no 1099 0.291294144529078 1310 1145395 SGTC_3268 9137683 49.47 µM 0.547673671236273 0.317872562538617 no 1100 0.291957996825085 1431 1953228 SGTC_2332 7982454 138.89 µM 0.547487459397548 0.317931054004962 no 1101 0.292021941878329 1420 2981748 SGTC_1818 st052136 56.3 µM 0.547022500644844 0.318077123191024 no 1102 0.292181636943112 1339 674169 SGTC_893 0958-0369 48.9 µM 0.546855981730692 0.318129442849434 no 1103 0.292238839528742 1499 6819948 SGTC_1229 0139-0193 12.2 µM 0.545976614890023 0.318405796993023 no 1104 0.292541006034176 1472 3090752 SGTC_1921 5740136 50 µM 0.545297421051564 0.318619312979841 no 1105 0.292774488770218 1529 1774243 SGTC_2387 9077560 195.08 µM 0.545006621463281 0.318710749134557 no 1106 0.292874481794966 1369 5303272 SGTC_307 1501-1223 22.3 µM 0.544171646424836 0.318973351786469 no 1107 0.293161680582154 1407 2830329 SGTC_1484 3473-2379 286 µM 0.543951281274164 0.319042672583526 no 1108 0.293237499358678 1496 671917 SGTC_1181 1222-0449 220 µM 0.5438848723376 0.319063564244077 no 1109 0.293260349782468 1463 658318 SGTC_980 1473-0395 201 µM 0.542521859138951 0.319492482943787 no 1110 0.293729526539979 1374 768876 SGTC_2569 tetrandrine 100 µM 0.541470562700198 0.319823474394092 no 1111 0.294091641189495 1377 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1287 0971-0001 34.6 µM 0.54021526119774 0.320218883035752 no 1112 0.294524294594162 1442 4665869 SGTC_2591 skatole 100 µM 0.539810236014867 0.32034650591457 no 1113 0.294663953606115 1427 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_912 3474-0017 2.18 µM 0.539597880047638 0.320413427481007 no 1114 0.294737189465814 1514 3360550 SGTC_2060 5238662 140 µM 0.539517277006762 0.320438830141196 no 1115 0.294764989483396 1410 790130 SGTC_999 SEC7.066 22.7 µM 0.53473744862499 0.321946730008922 no 1116 0.296415711090605 1491 740511 YDR170C SEC7 SGTC_1194 1488-0194 225 µM 0.534446220177416 0.32203869945122 no 1117 0.296516424127289 1437 1391452 SGTC_1375 2910-0797 186 µM 0.53338412325483 0.322374200157226 no 1118 0.296883852791838 1464 742508 SGTC_2777 climbazole 1.536 µM 0.53194027218386 0.322830523435942 no 1119 0.297383681808781 1451 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_3222 9128301 49.47 µM 0.52985571798189 0.323489809039015 no 1120 0.298105985225621 1431 4911358 SGTC_2639 lactacystin 53 µM 0.529382293511589 0.323639617166984 no 1121 0.298270139338745 1492 3870 A proteasome inhibitor. SGTC_37 0566-0070 1.56 µM 0.529347696666935 0.323650565944632 no 1122 0.298282136982786 1501 1626686 SGTC_3109 9122853 49.47 µM 0.528028916973103 0.324068030618512 no 1123 0.298739632856432 1523 1234709 SGTC_1879 gemcitabine 100 µM 0.527626259133588 0.324195537603088 no 1124 0.298879381813396 1447 60750 A nucleoside analog which inhibits DNA replication. SGTC_1975 st070967 30.8 µM 0.52606324978111 0.32469068067627 no 1125 0.299422130836948 1499 261391 SGTC_3353 9151644 39.2805 µM 0.526008670441529 0.324707976378118 no 1126 0.299441091376736 1429 4909158 SGTC_794 k038-0031 316 µM 0.526005306614968 0.324709042356868 no 1127 0.299442259967998 1431 6624242 SGTC_1438 4092-1045 4 µM 0.525156541439503 0.324978057391031 no 1128 0.299737186520189 1428 1351342 SGTC_102 gallobenzophenone 83.616 µM 0.52463559675089 0.325143215357749 no 1129 0.299918268053325 1519 70837 SGTC_2236 dapsone 200 µM 0.523637861276942 0.325459628836296 no 1130 0.300265221276168 1438 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1449 4112-4002 201 µM 0.522615385999722 0.325784018651924 no 1131 0.300620965646424 1365 2059539 SGTC_1757 st041620 31.8375 µM 0.522198085902096 0.325916448927541 no 1132 0.30076620929746 1417 5289815 SGTC_2033 5192550 145 µM 0.521303927212373 0.326200284317805 no 1133 0.301077532824344 1419 182073 SGTC_1428 4049-0204 61.7 µM 0.520926536161331 0.32632011088573 no 1134 0.301208974449862 1523 X1428 SGTC_1196 1588-0294 184 µM 0.520167363337804 0.326561212432028 no 1135 0.301473465215005 1415 6144269 SGTC_1824 st053723 68.6 µM 0.519804592603643 0.326676448399214 no 1136 0.301599889021001 1414 675225 SGTC_1741 st038134 10.228 µM 0.519620525066539 0.326734924712749 no 1137 0.301664044765411 1576 1272587 SGTC_629 3448-6466 76.7 µM 0.517794892083238 0.327315139307027 no 1138 0.302300691272662 1450 573744 SGTC_1223 0764-0573 147 µM 0.517461575076604 0.327421117750778 no 1139 0.302416992775128 1434 1609797 SGTC_848 0368-0089 85.6 µM 0.517391342761219 0.327443449953494 no 1140 0.302441500905997 1431 762535 SGTC_1424 4048-1941 275 µM 0.514065517601155 0.328501688879458 no 1141 0.30360309238955 1553 X1424 SGTC_3278 9139605 49.47 µM 0.512287594850071 0.329067968709088 no 1142 0.304224872959389 1507 7958859 SGTC_335 4077-0256 27.6 µM 0.51220366234382 0.329094711463531 no 1143 0.304254240107941 1483 3121989 SGTC_473 2-arachidonoylglycerol 10 µM 0.512069627901312 0.329137419617583 no 1144 0.304301140043206 1441 5282280 An endocannabinoid. SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.512006292933687 0.329157601173163 no 1145 0.304323302674997 1562 16725076 SGTC_2688 kanamycin b 96.69 µM 0.511374946337599 0.329358805662486 no 1146 0.304544267339988 1472 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_3229 9132204 49.47 µM 0.511026830602714 0.329469768162932 no 1147 0.304666134705435 1505 17682924 SGTC_2281 7943571 200 µM 0.510799950540649 0.329542094664255 no 1148 0.304745571902527 1522 1244024 SGTC_985 1493-0307 8.71 µM 0.510684342458788 0.329578951514837 no 1149 0.304786053138699 1503 3278274 SGTC_2261 9010538 184.68 µM 0.509529423906303 0.329947240302328 no 1150 0.305190589657065 1393 6457250 SGTC_1293 1000-1278 195 µM 0.508948233912289 0.330132636765 no 1151 0.305394254777684 1524 678847 SGTC_1719 st032227 49.2 µM 0.508186984083765 0.330375534445225 no 1152 0.305661109002866 1437 3125804 SGTC_1780 st038448 24.544 µM 0.507805315971035 0.33049734305796 no 1153 0.305794940675268 1566 728868 YDL195W SEC31 SGTC_2737 bleomycin 30.5 nM 0.507345924435632 0.330643980761255 no 1154 0.305956060416016 1478 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_472 calcifediol 10 µM 0.507268724234589 0.330668625605013 no 1155 0.305983140083452 1483 5283731 A vitamin D metabolite. SGTC_2022 5136654 200 µM 0.50686235388942 0.330798364487737 no 1156 0.306125700894841 1488 1713771 SGTC_816 0325-0417 81.3 µM 0.506514576888752 0.330909412845672 no 1157 0.306247729603541 1449 68101 SGTC_1481 3346-2004 36 µM 0.505872301744733 0.331114536247122 no 1158 0.306473148929832 1467 2770522 SGTC_1870 st057514 26.5 µM 0.504513330843361 0.331548717813042 no 1159 0.306950348371781 1472 5393161 SGTC_486 niguldipine 82 µM 0.503879883728292 0.331751177086741 no 1160 0.307172893712787 1487 1236 A calcium channel blocker. SGTC_315 k915-0449 187 µM 0.503451040959372 0.331888269623755 no 1161 0.307323596915528 1530 20970215 YNL149C PGA2 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.502471238440631 0.332201577527352 no 1162 0.307668039537736 1533 6710655 SGTC_1286 0929-0070 131 µM 0.500540356449833 0.332819351923243 no 1163 0.308347323662306 1537 1420408 SGTC_3311 9131146 2.8755 µM 0.500192906632593 0.332930564720141 no 1164 0.308469626265013 1468 4900406 YPR165W RHO1 SGTC_2881 9058953 51.95 µM 0.494564152588198 0.334734275307471 no 1165 0.310453905780088 1421 17122249 SGTC_1085 doxorubicin 7.67 µM 0.493988155172026 0.334919067401933 no 1166 0.310657272362069 1577 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2951 9072950 58.06 µM 0.49390381757642 0.334946128033906 no 1167 0.31068705417454 1472 16488155 SGTC_2297 7971671 152.32 µM 0.493835358122078 0.33496809462223 no 1168 0.310711229911961 1579 909016 SGTC_2556 citropten 84.59 µM 0.487779697469001 0.336913400938812 no 1169 0.312852946758171 1458 2775 A potential DNA crosslinker. SGTC_2809 7964133 12.99 µM 0.487706526158031 0.336936933145648 no 1170 0.312878864252893 1524 1253665 SGTC_1100 amiodarone 5.07 µM 0.486895966073685 0.337197655417046 no 1171 0.313166028879897 1541 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_590 k048-0076 22.4 µM 0.481195927877342 0.33903331491343 no 1172 0.315188627371583 1576 6832814 SGTC_689 0833-0039 98 µM 0.480447103535229 0.339274754248323 no 1173 0.315454753727076 1569 5374726 SGTC_2592 piperlongumine 83.33 µM 0.480325694874778 0.339313905599089 no 1174 0.315497910446777 1434 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_13 0199-0087 65 µM 0.479933949273402 0.3394402458893 no 1175 0.315637180070306 1534 4589825 SGTC_543 3844-1095 191 µM 0.479335048653208 0.339633429791131 no 1176 0.315850146065037 1583 4230703 SGTC_768 0384-0033 77.3 µM 0.47912079911302 0.339702549259638 no 1177 0.315926346957531 1475 3965305 YMR134W ERG29 SGTC_1262 0737-0114 49.6 µM 0.478485566103802 0.339907514717187 no 1178 0.316152322570274 1540 765919 SGTC_2064 5220758 200 µM 0.474099168164193 0.341324127077314 no 1179 0.317714595883964 1555 788518 SGTC_2450 5739737 12.93 µM 0.471075742457071 0.342301864584827 no 1180 0.31879332353759 1516 2262825 SGTC_1951 sophoraflavanone G 9.2 µM 0.470812929356868 0.342386905079048 no 1181 0.318887165330925 1502 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1623 st003709 20.3 µM 0.470219206867148 0.342579049932308 no 1182 0.319099206572473 1496 16192618 SGTC_3356 9151811 4.48 µM 0.470030238058043 0.342640213962302 no 1183 0.319166707059196 1494 1859254 YPR165W RHO1 SGTC_1460 k062-0059 9.15 µM 0.469422494227058 0.342836951967187 no 1184 0.319383836458905 1480 1373085 SGTC_2023 5144124 124 µM 0.46783039822231 0.343352545106261 no 1185 0.319952940166484 1511 2830192 SGTC_2302 7771753 200 µM 0.46780278463482 0.343361490218493 no 1186 0.319962814543651 1471 2203047 SGTC_2568 diosmetin 100 µM 0.467695591262877 0.343396215141528 no 1187 0.320001147163728 1532 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_756 0508-1999 28.3 µM 0.466870506541551 0.34366354272024 no 1188 0.320296263840996 1451 6753853 SGTC_2486 5283202 22.39 µM 0.465822845325077 0.344003097797549 no 1189 0.320671155609065 1484 1377751 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.464983186126985 0.344275328676957 no 1190 0.320971748718158 1554 688664 SGTC_1433 4060-0023 7.6 µM 0.464804737568393 0.34433319494406 no 1191 0.321035647394101 1565 3840627 SGTC_3104 9120930 49.47 µM 0.464362474987875 0.344476625002813 no 1192 0.321194035165565 1530 17014836 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.463562352400632 0.344736169366166 no 1193 0.321480666211698 1493 2374 Ca(2+)-ATPase inhibitor. SGTC_970 1315-0089 19.5 µM 0.462960548715884 0.344931431066947 no 1194 0.3216963227747 1458 6811083 YLR033W RSC58 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.462930663307094 0.344941128787312 no 1195 0.321707033788195 1567 368090 SGTC_577 r071-0003 38.6 µM 0.459498547777968 0.346055515505259 no 1196 0.322938097334544 1521 4568517 YMR134W ERG29 SGTC_1416 3966-0321 25.3 µM 0.455722549681095 0.347283100559103 no 1197 0.324294752230074 1546 582530 YLR208W SEC13 SGTC_1318 1280-3875 124 µM 0.452128798935325 0.348452926733346 no 1198 0.32558809894788 1566 373245 SGTC_3321 9137793 26.8275 µM 0.452039078515723 0.348482150741615 no 1199 0.32562041518849 1538 4904192 SGTC_216 k038-0035 28.382 µM 0.44696621690243 0.350135956990393 no 1200 0.327449726155507 1558 4444231 YPR107C YTH1 SGTC_722 3534-0461 190 µM 0.44689878258867 0.350157960523025 no 1201 0.327474071511968 1540 658262 SGTC_271 rotenone 740 µM 0.446424053751784 0.350312876775463 no 1202 0.32764548042726 1591 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_3192 9110362 49.47 µM 0.446091044327366 0.350421561196847 no 1203 0.327765740822745 1599 16649480 SGTC_1177 0983-0204 23.6 µM 0.444659011693832 0.350889073751291 no 1204 0.328283097263017 1667 766818 SGTC_1844 rapamycin 4 nM 0.443286116256645 0.351337491983298 no 1205 0.328779398379087 1564 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_954 1189-0853 2.85 µM 0.441375001671273 0.35196204913813 no 1206 0.329470768344353 1550 2828194 SGTC_1144 3486-0183 12.5 µM 0.439613256140135 0.352538146162086 no 1207 0.330108619016252 1574 6744069 SGTC_3146 9095609 49.47 µM 0.436951766265034 0.353409104230944 no 1208 0.331073164314656 1636 17173999 SGTC_696 1560-0013 611 µM 0.434363519931981 0.354256830659738 no 1209 0.332012242071133 1623 1650269 SGTC_322 k048-0136 19.3 µM 0.432531178529813 0.354857413308658 no 1210 0.33267769834645 1581 6823282 SGTC_1896 st058441 89 µM 0.43222488546929 0.354957841578662 no 1211 0.332788987125952 1528 688759 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.432058086691989 0.355012536291687 no 1212 0.332849598131933 1550 688803 SGTC_1731 st035964 63 µM 0.431923220253851 0.3550567623085 no 1213 0.332898608822317 1556 6739575 SGTC_2783 7738165 71.43 µM 0.431365175838136 0.355239779526976 no 1214 0.333101433440676 1483 17201110 SGTC_1189 1431-2119 7.28 µM 0.430720626285461 0.35545120868125 no 1215 0.333335759641751 1590 3107275 SGTC_1369 1866-0067 208 µM 0.428588872988478 0.356150796266087 no 1216 0.334111222257404 1689 3531355 SGTC_2722 naftopidil 47.16 µM 0.428343652272153 0.356231302627978 no 1217 0.334200471102778 1626 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1444 4112-3581 28 µM 0.426823602839603 0.356730480203836 no 1218 0.334753906840412 1604 2877249 SGTC_2018 5133068 143 µM 0.426024878412221 0.356992876239808 no 1219 0.335044858931428 1562 785362 SGTC_1881 5652484 16 µM 0.425967755634835 0.357011644743372 no 1220 0.335065670894648 1690 2255129 SGTC_212 3807-4682 38.772 µM 0.42381262526293 0.357719996024038 no 1221 0.335851234924662 1690 3125501 YBL034C STU1 SGTC_2521 angolensin 13.4 µM 0.422895805518063 0.358021486430249 no 1222 0.336185641627257 1627 821428 A flavenoid. SGTC_402 epigallocatechin gallate 10 µM 0.417180756057958 0.359902834694819 no 1223 0.338273099963751 1574 65064 An antioxidant. SGTC_373 0844-0104 25.9 µM 0.41579375592153 0.360359938297782 no 1224 0.338780464170406 1721 5375804 SGTC_1358 1509-0022 2.48 µM 0.41551293036698 0.360452512271237 no 1225 0.33888322572366 1602 3258434 SGTC_2414 st077232 92.9 µM 0.41255669130098 0.36142753007073 no 1226 0.339965718629563 1525 729801 SGTC_2908 7930301 100 µM 0.408287007093376 0.36283733286784 no 1227 0.34153148853667 1526 2223178 SGTC_2947 9072639 7.68 µM 0.408211592349917 0.362862250769453 no 1228 0.341559169100876 1539 16488146 SGTC_1720 st037298 9.481 µM 0.407949693344204 0.362948789732731 no 1229 0.341655304298946 1597 597396 SGTC_1070 indatraline 8.81 µM 0.406316870798642 0.363488478941874 no 1230 0.342254895468415 1584 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_3326 9140064 16.379 µM 0.406280312003215 0.363500565655963 no 1231 0.342268324836974 1548 1868434 SGTC_856 0433-0016 11.3 µM 0.405691379642214 0.363695291474124 no 1232 0.342484688483594 1615 3911780 SGTC_1273 0849-0096 14.1 µM 0.405594661108778 0.363727274058503 no 1233 0.342520226157824 1600 5286025 SGTC_115 0527-0192 112.043 µM 0.405063861322017 0.36390281418439 no 1234 0.342715284841011 1619 4233931 SGTC_2188 6126565 140.678 µM 0.404827942381781 0.363980843810466 no 1235 0.342801993967691 1669 874518 SGTC_871 0574-0004 149 µM 0.40375817634232 0.364334737101597 no 1236 0.343195277275363 1621 9551173 SGTC_2068 5226020 147 µM 0.402807602298609 0.364649297128396 no 1237 0.343544884024708 1587 1810509 SGTC_3298 9116858 71.43 µM 0.402483657875408 0.364756516310758 no 1238 0.343664056483695 1703 2506942 SGTC_1133 3473-0247 50 µM 0.402369456010875 0.364794317386474 no 1239 0.343706072694841 1550 711311 SGTC_275 trichlorophene 5.69 µM 0.400734562238813 0.365335614858595 no 1240 0.344307780813721 1654 62616 SGTC_1093 fluphenazine 7.97 µM 0.397790529556752 0.366311031656785 no 1241 0.345392299384545 1652 6602611 An atypical antipsychotic. SGTC_1098 clofazimine 15.1 µM 0.396101933923615 0.366870887598217 no 1242 0.346014915839708 1687 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2253 7938677 135.83 µM 0.395933463829527 0.366926759624201 no 1243 0.346077056759624 1748 2301972 SGTC_2887 9044784 58.44 µM 0.395365289977541 0.367115211616116 no 1244 0.346286660687064 1598 6465546 SGTC_145 3737-0113 38.366 µM 0.394988476836687 0.367240210720371 no 1245 0.346425696075554 1761 6849351 SGTC_2658 polymyxin b sulfate 77.05 µM 0.392620734153197 0.368025976493721 no 1246 0.347299811613887 1627 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1856 st057054 55.7 µM 0.392607998095307 0.368030204614734 no 1247 0.347304515672266 1753 1266018 SGTC_423 5-fluorouracil 457 µM 0.392606948415024 0.36803055308868 no 1248 0.347304903372349 1533 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1768 st044301 37.178 µM 0.392129060606551 0.36818921405271 no 1249 0.347481428128479 1581 3931349 SGTC_713 1488-1073 324 µM 0.391432807226529 0.368420413633282 no 1250 0.347738673130348 1693 3312542 SGTC_2116 5511452 16.8835 µM 0.389355600131088 0.369110458880581 no 1251 0.348506555859531 1666 870744 SGTC_204 PMA1.184 62.41 µM 0.388529672259913 0.369384948335874 no 1252 0.34881205003175 1649 2252213 YGL008C PMA1 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.387572689005196 0.369703076111115 no 1253 0.34916614157222 1590 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2689 tacrolimus 100 µM 0.386562306208018 0.370039052187593 no 1254 0.349540133925682 1635 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_3054 9094397 49.47 µM 0.385795465217482 0.370294111110333 no 1255 0.34982407702013 1582 2598354 SGTC_883 0850-0245 24.6 µM 0.385790404584786 0.37029579451656 no 1256 0.349825951132017 1744 6823229 YPR165W RHO1 SGTC_1328 1441-0025 69.2 µM 0.385689515124064 0.370329355650118 no 1257 0.349863314444649 1548 4562601 SGTC_1329 1447-1697 50.6 µM 0.38526298880752 0.370471251610225 no 1258 0.350021289881577 1660 2840515 SGTC_2862 9027634 71.43 µM 0.385216854074812 0.370486600681572 no 1259 0.350038378670937 1582 5012562 SGTC_2603 homopterocarpin 100 µM 0.382522867464219 0.371383249490136 no 1260 0.351036785223669 1641 101795 A weak amylase inhibitor. SGTC_291 SEC14.278 35.5 µM 0.38088859501145 0.371927530700557 no 1261 0.35164295780935 1743 1068044 SGTC_391 gliotoxin 8.33 µM 0.380658084240723 0.372004321075482 no 1262 0.351728487612138 1707 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2850 9015429 58.44 µM 0.379705285482675 0.372321782241017 no 1263 0.352082098135955 1601 6457570 SGTC_3025 9087895 49.47 µM 0.378532048227714 0.372712810088551 no 1264 0.352517695363999 1750 17173641 SGTC_1453 4237-0541 195 µM 0.37846982784958 0.372733551164579 no 1265 0.352540801831469 1792 739892 SGTC_1024 4507-0395 26 µM 0.378214932406268 0.372818524055675 no 1266 0.352635466744124 1682 4201836 SGTC_131 0141-0277 33.849 µM 0.377250778593054 0.373139993896346 no 1267 0.352993623665305 1756 1547771 SGTC_1325 1431-0015 227 µM 0.376521463767704 0.373383222010019 no 1268 0.353264630860642 1584 1103340 SGTC_2925 9010536 32.5 µM 0.372439405033642 0.374745526681488 no 1269 0.35478285986191 1745 2994177 SGTC_273 hydroxyurea 18.1 mM 0.371838175773462 0.374946307405079 no 1270 0.355006669115023 1698 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1840 st055363 71 µM 0.370830242605266 0.375282983064679 no 1271 0.355381987250612 1598 676033 SGTC_3151 9099821 49.47 µM 0.365939099834064 0.376918095939849 no 1272 0.357205259715224 1637 17174189 SGTC_1633 st005664 67.9 µM 0.364956209175736 0.377246944670523 no 1273 0.357572047456524 1632 2063822 SGTC_1217 1183-1422 255 µM 0.363575845880736 0.377708927317802 no 1274 0.358087383154627 1769 2849664 SGTC_213 1246-0773 967 nM 0.363150326322907 0.377851376340383 no 1275 0.358246296015217 1709 6251622 SGTC_375 3970-0961 9.27 µM 0.362830962124525 0.377958299185609 no 1276 0.358365580646713 1706 2898222 SGTC_2957 9076800 11.52 µM 0.361126942418074 0.378528961291142 no 1277 0.359002276613763 1631 16459615 SGTC_1094 duloxetine 25.4 µM 0.360494750404705 0.378740744629036 no 1278 0.359238590839759 1691 60834 A selective serotonin reuptake inhibitor. SGTC_3038 9091290 49.47 µM 0.3596698571149 0.379017137345685 no 1279 0.359547018041828 1753 25236843 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.358019050358473 0.379570450276638 no 1280 0.360164528551192 1677 6857784 SGTC_2555 cholic acid 100 µM 0.357978822023425 0.37958393698471 no 1281 0.360179581161926 1732 6708657 Influences liver metabolism. SGTC_2561 acetosyringone 100 µM 0.356903570658266 0.379944473490265 no 1282 0.360581998241293 1677 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1295 1013-0063 9.78 µM 0.356628570881766 0.380036698895328 no 1283 0.360684942816061 1819 6826038 SGTC_1934 st074720 32.6 µM 0.355526960604004 0.380406209198972 no 1284 0.361097425411593 1615 17250992 SGTC_397 arbidol 50 µM 0.354493618521814 0.380752919704531 no 1285 0.361484492813682 1778 131410 A RNA synthesis inhibitor. SGTC_338 4055-0136 114 µM 0.351367193201047 0.381802490980446 no 1286 0.362656445659512 1661 2900563 SGTC_2165 5727197 32.143 µM 0.351043517046685 0.381911202000518 no 1287 0.3627778506948 1746 1361712 SGTC_2795 7780010 54.55 µM 0.347683748226629 0.38304017440294 no 1288 0.364038851566193 1720 953673 SGTC_2714 st079313 56.9 µM 0.346101508306998 0.383572194402825 no 1289 0.364633214968082 1699 2939799 SGTC_2698 st077697 67.5 µM 0.345850810102022 0.383656510556821 no 1290 0.364727418865841 1636 3154499 SGTC_1258 0671-0043 57.1 µM 0.34536712886229 0.383819200369177 no 1291 0.364909192977679 1670 4298767 SGTC_3102 9121669 49.47 µM 0.345337169323627 0.383829278158523 no 1292 0.364920453186562 1757 41905072 SGTC_3198 9112019 49.47 µM 0.344177525966726 0.3842194192956 no 1293 0.36535639134242 1731 45595555 SGTC_134 0269-0018 6.916 µM 0.342203754243704 0.384883728896912 no 1294 0.366098780062379 1674 4378915 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.34036874877026 0.385501637453486 no 1295 0.366789425055352 1675 16623 A steroid. SGTC_1425 4048-4433 7.33 µM 0.337556059027514 0.386449329332447 no 1296 0.367848880080555 1814 23734946 SGTC_294 k038-0071 157 µM 0.337492987390747 0.386470588125049 no 1297 0.367872648819717 1728 24152826 SGTC_549 1661-1316 519 µM 0.3371760151806 0.38657743126653 no 1298 0.367992108425235 1838 2857282 SGTC_2621 lithochol-11-enic acid 100 µM 0.33485582220896 0.38735976970379 no 1299 0.368866924406961 1871 6708711 SGTC_2416 tofa 880 nM 0.334444911898705 0.387498371030955 no 1300 0.369021926867916 1605 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1156 4092-0367 4.88 µM 0.333899429143969 0.387682386213066 no 1301 0.369227725284023 1746 1357585 SGTC_2872 9044037 25.97 µM 0.331871862903525 0.388366593835638 no 1302 0.369993008777028 1814 6465195 SGTC_1202 1988-0068 29.6 µM 0.330813215876738 0.388723974945581 no 1303 0.370392788805901 1647 2850480 SGTC_1684 st024538 14.6195 µM 0.330347731036875 0.388881144490671 no 1304 0.370568615578332 1709 6732859 SGTC_2882 9058044 58.44 µM 0.330187090791022 0.388935388405395 no 1305 0.370629300214277 1630 18076804 SGTC_3348 9149464 3.537 µM 0.327475328105213 0.389851404110172 no 1306 0.371654200240445 1727 1951442 SGTC_341 1486-1430 230 µM 0.327185030880153 0.389949500974601 no 1307 0.371763971007177 1680 2054753 YPL210C SRP72 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.32619338945101 0.390284648002195 no 1308 0.372139021284393 1692 4174840 SGTC_534 k292-0788 63.4 µM 0.324618012438349 0.390817248913513 no 1309 0.372735096485205 1910 4146317 SGTC_1865 st057639 52.2 µM 0.324237227031179 0.390946015011134 no 1310 0.372879220018489 1757 688818 SGTC_2110 5483698 200 µM 0.32392157757389 0.391052763851172 no 1311 0.372998703725497 1750 2848765 YHR062C RPP1 SGTC_1845 st056753 3.01 µM 0.323506244378384 0.391193237034749 no 1312 0.373155939620102 1673 5375839 SGTC_741 4582-0002 126 µM 0.321915589106007 0.391731356491018 no 1313 0.373758321463606 1712 2912688 SGTC_1368 1852-0141 284 µM 0.320247684779813 0.392295831889465 no 1314 0.374390288905556 1746 2838987 SGTC_2671 danthron 100 µM 0.319932366705961 0.392402571737148 no 1315 0.374509800637093 1751 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2778 tioconazole 65.09 nM 0.31754039935055 0.393212551269134 no 1316 0.375416795040144 1705 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2362 9071156 126 µM 0.317422520072934 0.39325248010477 no 1317 0.375461510766392 1816 653133 SGTC_3223 9129970 49.47 µM 0.316652948095283 0.393513182107232 no 1318 0.375753477383072 1763 17248386 SGTC_2792 7535235 81.82 µM 0.31659546389415 0.393532657507478 no 1319 0.375775289075369 1675 1281891 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.31650595457189 0.393562983411375 no 1320 0.375809253106948 1855 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_190 3970-0790 3.722 µM 0.315181477796417 0.394011793662774 no 1321 0.376311933993534 1840 2832352 SGTC_2937 9044753 11.33 µM 0.314764159346567 0.394153234776513 no 1322 0.376470363085053 1713 6465530 YGL099W LSG1 SGTC_2163 5671233 125 µM 0.311874740211617 0.395132923245152 no 1323 0.377567860054711 1869 701023 SGTC_1853 st056710 91.2 µM 0.311503671572423 0.395258786226415 no 1324 0.377708876065818 1909 269167 SGTC_2170 morpholine 200 µM 0.310987937582105 0.39543373647608 no 1325 0.377904895849495 1838 121171 Reacts with secondary amines. SGTC_1860 st056228 74.6 µM 0.310339690817009 0.395653668361781 no 1326 0.378151325579643 1727 688679 SGTC_1353 1498-1206 8.11 µM 0.309356217852945 0.39598739649361 no 1327 0.37852528552769 1753 6756808 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.305645259045796 0.39724734451501 no 1328 0.379937378352687 1713 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1651 st011928 86.1 µM 0.304885557458721 0.397505411818714 no 1329 0.380226657944986 1797 720198 SGTC_3309 9129340 25.759 µM 0.303938743519133 0.397827103163361 no 1330 0.380587280066249 1805 17158987 SGTC_1232 0279-0259 161 µM 0.3036577250818 0.397922595915416 no 1331 0.380694334246168 1732 1560000 SGTC_2817 7995342 71.43 µM 0.303596558018591 0.397943381878986 no 1332 0.380717637094705 1682 18879975 SGTC_171 k064-0041 9.68 µM 0.302630428431649 0.39827173313992 no 1333 0.381085761342027 1715 53325 SGTC_2725 haloperidol 53.21 µM 0.30125040319331 0.39874087693293 no 1334 0.381611778827201 1778 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_596 1155-0152 116 µM 0.300070148632182 0.399142224207736 no 1335 0.382061824258994 1748 280313 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.299440720806288 0.399356305679943 no 1336 0.382301897965178 1842 5357218 A potent inhibitor of glutathione S-transferases. SGTC_661 1304-0007 33.6 µM 0.294978559117589 0.400874843836177 no 1337 0.38400512934351 1762 3117130 SGTC_2683 piperine 63.03 µM 0.293672718834076 0.401319524729273 no 1338 0.38450400137801 1805 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2938 9059746 27.26 µM 0.292146298128173 0.401839482426172 no 1339 0.385087384574186 1816 6471769 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.291278466700907 0.402135176798936 no 1340 0.385419177437537 1768 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3165 9101544 49.47 µM 0.291011403183499 0.402226184067952 no 1341 0.385521299143788 1872 5002184 SGTC_2643 anethole 100 µM 0.289425409322858 0.402766752443204 no 1342 0.386127926408107 1810 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_692 k241-0027 77.8 µM 0.289060521182783 0.402891146855927 no 1343 0.38626753204331 1890 3600480 SGTC_2835 9006588 71.43 µM 0.287864791302798 0.403298853253139 no 1344 0.386725119540127 1758 2345538 SGTC_786 4544-0069 423 µM 0.287243087494132 0.403510876328626 no 1345 0.386963098342836 1856 748821 YLR208W SEC13 SGTC_480 am 92016 50 µM 0.28613567931155 0.403888612059042 no 1346 0.387387102649321 1769 2129 K+ channel blocker. SGTC_2630 antimycin a 100 µM 0.285107236508449 0.404239493081177 no 1347 0.387780993055343 1758 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_965 1291-5240 308 µM 0.283704534687534 0.404718186827607 no 1348 0.388318409644737 1897 2834598 SGTC_1867 st057372 64 µM 0.282078265043931 0.405273355073914 no 1349 0.388941749386599 1835 688837 SGTC_2106 5357045 167.29 µM 0.281972640297334 0.405309419356308 no 1350 0.388982244648412 1866 668842 SGTC_619 1652-1634 108 µM 0.281414128335231 0.405500129817365 no 1351 0.389196391480286 1800 5400454 SGTC_1978 st071761 42 µM 0.280927041785895 0.405666469550811 no 1352 0.3893831795833 1761 5147680 SGTC_1236 0330-0013 258 µM 0.279842518625218 0.406036894641818 no 1353 0.389799164622138 1797 4617066 SGTC_93 0109-0045 59.227 µM 0.278386580919185 0.406534310731091 no 1354 0.390357809708238 1938 88733 SGTC_504 lovastatin 124 µM 0.277669336622604 0.406779410281966 no 1355 0.39063310055879 1756 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2005 4024620 188 µM 0.276109998983529 0.407312399172915 no 1356 0.391231790507295 1812 236743 SGTC_2299 7976368 114.88 µM 0.274741697159757 0.407780232567873 no 1357 0.391757346849566 1918 2979718 SGTC_2917 7979103 53.79 µM 0.271936299904633 0.408739831051357 no 1358 0.392835499655791 1914 2980565 SGTC_1457 k015-0032 57.3 µM 0.271892287351974 0.408754890114514 no 1359 0.392852420862263 1801 4302660 SGTC_1488 4013-0813 75.9 µM 0.271134359659326 0.409014239087842 no 1360 0.393143847904636 1810 2910057 SGTC_1863 st057641 20.1 µM 0.270694750473632 0.409164683560425 no 1361 0.393312907320982 1990 3921635 SGTC_3206 9114350 49.47 µM 0.269329489110926 0.409631992916455 no 1362 0.39383807063376 1910 17087243 SGTC_2241 6772625 37.8075 µM 0.268361004088689 0.409963569326757 no 1363 0.394210726567782 1862 2285411 SGTC_889 0919-1524 82.7 µM 0.267186753688754 0.410365679167025 no 1364 0.394662687278945 1820 3905452 SGTC_246 cycloheximide 667 µM 0.266210865048398 0.410699933818544 no 1365 0.395038407879819 1816 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2260 7964312 200 µM 0.26609358270538 0.410740108929218 no 1366 0.395083568577084 1954 231951 SGTC_2540 epiandrosterone 100 µM 0.266028702044227 0.410762334226421 no 1367 0.395108552106916 1891 441302 A steroid. SGTC_2256 7954252 200 µM 0.265868788685564 0.410817114822423 no 1368 0.395170131621417 1826 2972920 SGTC_1112 tnp00069 1.16933 µM 0.264618997328652 0.411245308474598 no 1369 0.395651491966016 1939 145826 SGTC_337 1315-0038 354 µM 0.263313415781851 0.411692729459816 no 1370 0.39615451007522 1841 1626437 SGTC_1507 4075-3230 155 µM 0.263002662686093 0.411799241057308 no 1371 0.396274263409407 1965 659771 SGTC_401 neomycin 50 µM 0.262253170359593 0.412056158626454 no 1372 0.396563131691545 1866 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2710 st078562 53.7235 µM 0.262183839766226 0.412079926283349 no 1373 0.396589855863323 1843 17250908 SGTC_1766 st045414 44.774 µM 0.262087504050036 0.41211295227167 no 1374 0.396626990236666 1841 253960 SGTC_1901 st060216 58.6 µM 0.261016001360946 0.412480328716145 no 1375 0.397040083789347 1787 688792 SGTC_1221 2958-7315 257 µM 0.260920916376701 0.412512933354816 no 1376 0.397076747236227 1882 4562705 SGTC_1914 st062367 72.6 µM 0.258889073154998 0.413209796275244 no 1377 0.397860414603823 1816 978205 SGTC_1324 1418-0026 34.4 µM 0.258868847532301 0.413216734452045 no 1378 0.397868217559225 1881 1372513 SGTC_569 4130-2812 160 µM 0.258109185521658 0.413477347734381 no 1379 0.398161321346785 1993 743552 SGTC_1754 st042065 16.137 µM 0.25689617864474 0.413893566667233 no 1380 0.398629460305505 1882 1126236 YIL048W NEO1 SGTC_1165 k072-0275 30.3 µM 0.256632303048856 0.413984123103342 no 1381 0.398731317857769 1955 6153523 YGL055W OLE1 SGTC_1265 0819-1001 68.8 µM 0.255792752728915 0.41427226914175 no 1382 0.399055435137483 1868 3106768 SGTC_1797 st048695 56.8 µM 0.254758115672306 0.414627435287102 no 1383 0.399454963447255 1960 592262 YIL048W NEO1 SGTC_2575 plumbagin 510 nM 0.254702240692492 0.414646617820005 no 1384 0.399476542745197 1771 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1391 3442-0225 151 µM 0.25457080579436 0.41469174175749 no 1385 0.399527305009224 1859 5227075 SGTC_3030 9087619 49.47 µM 0.252369475512879 0.415447664448495 no 1386 0.400377745850437 1822 25236973 SGTC_342 k048-0088 23.3 µM 0.249082707254205 0.416576901417345 no 1387 0.401648402798084 1815 6820570 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.248653979795029 0.41672425055357 no 1388 0.401814224836766 1831 2333 A French combination drug. SGTC_1062 mesoridazine 14.2 µM 0.246902655031714 0.417326283836717 no 1389 0.402491780756495 1879 4078 A neuroleptic. SGTC_2612 dictamnine 15.46 µM 0.245281505248182 0.417883741156118 no 1390 0.40311923555074 1876 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_636 0kpi-0074 126 µM 0.244719236591116 0.418077124496155 no 1391 0.403336916104131 1861 616434 SGTC_2012 4023501 200 µM 0.24451041509762 0.418148950366261 no 1392 0.40341776832442 1828 3477460 SGTC_853 0419-0306 21 µM 0.242455953458815 0.418855744521265 no 1393 0.404213441395854 1838 762713 SGTC_533 1222-0222 6.71 µM 0.240946051581024 0.419375361554216 no 1394 0.404798464672832 1984 3982874 SGTC_81 0411-0046 9.971 µM 0.240898562430546 0.419391706737501 no 1395 0.404816868174631 1914 12925265 SGTC_20 0481-0013 4.944 µM 0.240553229653936 0.419510570226477 no 1396 0.404950701542881 1825 182045 SGTC_2322 7413319 38.22 µM 0.240305183484844 0.419595952213153 no 1397 0.405046838446719 1881 1840400 SGTC_1792 st045773 43.6 µM 0.240181210173448 0.41963862749272 no 1398 0.405094889755894 1856 2919270 SGTC_1682 st012968 530 nM 0.239661048118092 0.419817692949236 no 1399 0.405296517024906 1795 24207270 SGTC_925 2064-1272 59.6 µM 0.239539671545616 0.419859479147415 no 1400 0.405343569110021 1817 6815817 SGTC_2703 st077852 53.4 µM 0.239438465390506 0.419894321985825 no 1401 0.405382803102875 1895 6281836 SGTC_2187 6125751 200 µM 0.239277366321293 0.419949785805279 no 1402 0.405445257389324 1910 874498 SGTC_924 2046-0044 21.3 µM 0.239037766595845 0.420032279079094 no 1403 0.405538148970019 1888 3623589 SGTC_2441 5730946 39.09 µM 0.238100072346559 0.420355157389755 no 1404 0.405901739313256 1952 1774275 SGTC_1817 st052116 64.4 µM 0.237711997971524 0.420488799581864 no 1405 0.406052238672939 1976 4361398 SGTC_155 k072-0202 43.6 µM 0.236447350511451 0.420924373075663 no 1406 0.406542778607915 1997 5857737 SGTC_643 k048-0106 28.4 µM 0.235702020660465 0.421181127092345 no 1407 0.406831950903726 1953 6763920 SGTC_1171 0368-0077 21.4 µM 0.235445970224437 0.42126934004672 no 1408 0.406931304816441 1866 3239779 SGTC_772 k072-0172 35.3 µM 0.234566863960813 0.42157223449388 no 1409 0.407272465374156 1773 5861980 SGTC_3310 9130229 44.1445 µM 0.231945699697581 0.422475626631227 no 1410 0.408290094508803 1974 7761258 SGTC_1735 st034310 56.75 µM 0.231721777733235 0.422552820989397 no 1411 0.408377057761038 1949 871153 SGTC_2172 5754775 163.918 µM 0.231525645077554 0.422620437767134 no 1412 0.408453232350727 1837 2263357 SGTC_2730 imipramine 71.33 µM 0.231400529284419 0.422663572656628 no 1413 0.408501827005434 2007 3696 A tricyclic antidepressant. SGTC_298 1391-0729 10 µM 0.230722161047421 0.422897462851863 no 1414 0.408765327972736 1877 3237558 SGTC_27 0485-0001 32.618 µM 0.230493127320578 0.422976436050348 no 1415 0.408854301670334 2000 2054479 SGTC_2266 7929956 200 µM 0.230343175108115 0.423028142801404 no 1416 0.40891255678322 1857 2967153 SGTC_785 1270-0111 65.3 µM 0.230179109046796 0.423084717830377 no 1417 0.40897629730714 1914 6741994 SGTC_1644 st010134 20.9 µM 0.230010717060189 0.423142786220996 no 1418 0.409041720978892 2013 3818134 SGTC_108 0509-0257 621.132 µM 0.229724058453225 0.42324164158157 no 1419 0.409153099437666 1986 536624 SGTC_2144 5628481 200 µM 0.229334223027619 0.423376085631774 no 1420 0.409304578030268 1887 2818399 SGTC_71 0417-1750 47.813 µM 0.229181658508025 0.423428703577347 no 1421 0.409363863808516 2039 6811472 SGTC_187 1488-2104 32.728 µM 0.227660109485391 0.423953544877438 no 1422 0.409955243054631 1989 2852859 SGTC_2366 9070441 60.58 µM 0.227260122999035 0.424091538170244 no 1423 0.410110739546442 1851 6837235 SGTC_2274 7947094 46.08 µM 0.226902025810099 0.424215087766273 no 1424 0.410249963384211 2034 2971028 SGTC_1944 st076371 56.9 µM 0.225957168189291 0.424541115371803 no 1425 0.410617366811281 1833 24208455 SGTC_1662 st014054 52 µM 0.225715045023548 0.424624669438913 no 1426 0.410711527901099 2012 2838777 SGTC_3158 9100007 49.47 µM 0.225330542725645 0.424757363952334 no 1427 0.410861070450085 1846 19297233 SGTC_1077 5-fluorocytosine 377 nM 0.224721717164441 0.424967491474607 no 1428 0.41109788441256 1921 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1197 1601-0112 267 µM 0.223707877819359 0.425317451054158 no 1429 0.411492307840806 1847 7350313 SGTC_711 k292-0785 179 µM 0.223534430398229 0.425377327968142 no 1430 0.411559794690566 1923 4146315 SGTC_2078 5212016 200 µM 0.223511149783716 0.425385364951759 no 1431 0.411568853169946 2056 1899708 SGTC_1136 pergolide 1.05886 µM 0.222618619347011 0.42569350957057 no 1432 0.411916171966318 1879 47811 A dopamine receptor agonist. SGTC_2986 9022445 71.43 µM 0.219288824088191 0.426843514781706 no 1433 0.41321253356723 2028 6459286 SGTC_325 2810-4341 181 µM 0.219243028225705 0.42685933557298 no 1434 0.413230369523623 2031 774970 SGTC_3283 9109332 35.8195 µM 0.217924586673899 0.427314859141462 no 1435 0.413743935052211 1936 17027281 SGTC_59 0330-0160 1.33 µM 0.216666904401623 0.427749480626074 no 1436 0.414233970888193 1967 4293482 SGTC_1401 3807-4679 7.6 µM 0.215853069696653 0.428030766977585 no 1437 0.414551139816792 1912 3291456 SGTC_3197 9113331 49.47 µM 0.21523895647628 0.428243047651011 no 1438 0.414790509875939 2015 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.214731557908325 0.428418455913389 no 1439 0.414988308398737 1868 688669 SGTC_1467 k284-1082 293 µM 0.213841099817742 0.428726322456651 no 1440 0.415335486586911 2054 3334705 SGTC_896 0964-0007 44.5 µM 0.213705443509331 0.428773228013934 no 1441 0.415388383051428 2054 6756758 SGTC_1753 st043925 64 µM 0.213087070516046 0.428987054099804 no 1442 0.415629524647068 2042 670181 SGTC_1826 st055655 41.6 µM 0.212993275880312 0.429019489000267 no 1443 0.415666103711796 1922 676168 SGTC_500 h-89 112 µM 0.212868523254617 0.429062630152464 no 1444 0.41571475724662 2042 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_268 camptothecin 39.6153 µM 0.211549185206312 0.429518926938496 no 1445 0.416229378144961 1978 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2883 9059145 45.46 µM 0.209589113518632 0.430196996978924 no 1446 0.416994188542984 1908 16476510 SGTC_2315 7733312 200 µM 0.20941460619632 0.430257376306227 no 1447 0.417062295723841 1908 726316 SGTC_3010 9080089 71.4286 µM 0.209405650509392 0.430260475007327 no 1448 0.417065791040264 2018 17027233 SGTC_3170 9103054 49.47 µM 0.208624251169333 0.430530858610114 no 1449 0.417370788715892 1924 16432970 SGTC_2138 5575593 77.673 µM 0.208455241503023 0.430589344446156 no 1450 0.417436763523295 1906 762213 SGTC_765 1319-0117 244 µM 0.206026357763103 0.431430027803046 no 1451 0.418385161216162 1930 3487746 YGL099W LSG1 SGTC_1032 k061-1018 98.7 µM 0.205397601667115 0.431647703154753 no 1452 0.418630746962498 2082 4005393 SGTC_2799 7812892 81.82 µM 0.204404599993282 0.431991522572898 no 1453 0.419018667898842 2028 20205235 SGTC_284 0988-0104 32.6 µM 0.204009104080936 0.432128474440551 no 1454 0.419173192249458 2031 4666532 SGTC_54 0159-0055 9 µM 0.20321409790243 0.432403792921166 no 1455 0.419483847098539 2074 3319099 SGTC_2950 9072895 21.46 µM 0.201896932104943 0.432860012610348 no 1456 0.41999865025814 1886 17332245 SGTC_349 k015-0014 24 µM 0.198586844958779 0.434006903617464 no 1457 0.421292972430121 1889 2196908 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.198281503140462 0.434112727703644 no 1458 0.421412411368779 1991 5355888 SGTC_2854 9024559 71.43 µM 0.198220584207393 0.434133841297126 no 1459 0.421436241570182 1897 3163529 SGTC_914 3820-6779 408 µM 0.196662571232668 0.434673889044123 no 1460 0.422045800930189 1959 2893481 SGTC_1801 st050089 28.441 µM 0.196313695581946 0.434794835143841 no 1461 0.422182321217106 1975 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2008 4012253 172 µM 0.196072660282126 0.434878399368083 no 1462 0.422276647416186 1929 603940 SGTC_2720 fluspirilene 36.88 µM 0.195504973123558 0.435075221600579 no 1463 0.4224988224059 2033 3396 An atypical antipsychotic. SGTC_2793 7325131 81.82 µM 0.195280763297196 0.435152961594001 no 1464 0.422586577912753 1963 4176441 SGTC_776 4476-4378 112 µM 0.194284030645296 0.435498587762534 no 1465 0.422976744547843 1911 2892008 SGTC_2458 5808907 16.39 µM 0.193685335275281 0.435706214566862 no 1466 0.423211137579378 2068 2731747 SGTC_159 3970-0959 50 µM 0.192955781858079 0.43595924672935 no 1467 0.423496799100098 2038 6615653 SGTC_1703 st026983 48.3 µM 0.190588256192756 0.436780559440755 no 1468 0.42442409586946 2084 1104023 SGTC_1635 st007035 42.4 µM 0.189761411023393 0.43706746274069 no 1469 0.424748047968869 2035 3716403 SGTC_1713 st033146 12.748 µM 0.189413926878663 0.437188044593792 no 1470 0.424884204985949 2061 674619 SGTC_31 0508-1974 57.237 µM 0.189150000208898 0.437279634735287 no 1471 0.424987627112771 2034 6810525 SGTC_550 4123-0385 25.7 µM 0.188157217665913 0.437624188880199 no 1472 0.425376704392031 1962 5731123 SGTC_3349 9149703 23.001 µM 0.185193862792406 0.438652928265305 no 1473 0.426538491308084 2058 4910494 SGTC_3033 9090887 49.47 µM 0.184141593356243 0.43901832752435 no 1474 0.426951188781999 1941 19325384 SGTC_1170 0310-0127 64.8 µM 0.180111395912294 0.440418286660502 no 1475 0.428532558134905 2006 774975 SGTC_1637 st007924 17.4 µM 0.179046277448871 0.44078839927292 no 1476 0.428950682305386 1998 683336 SGTC_3185 9108267 49.47 µM 0.1788347944044 0.440861892608711 no 1477 0.429033711844263 1942 4910486 SGTC_1090 efavirenz 20.7 µM 0.178614963367783 0.440938289148339 no 1478 0.429120022184615 2023 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_34 0469-0683 81.75 µM 0.176725061208036 0.441595165705157 no 1479 0.42986217735471 2040 3690923 SGTC_3328 9140624 29.0385 µM 0.17324992853871 0.442803441625868 no 1480 0.431227489832429 2100 4904392 SGTC_3249 9135183 49.47 µM 0.172346303266873 0.443117712558811 no 1481 0.431582642089793 2043 4902779 SGTC_2194 5927483 104.545 µM 0.172293058955385 0.44313623146326 no 1482 0.431603570454519 2073 760979 SGTC_1812 st052057 4.327 µM 0.171911536922809 0.443268932276242 no 1483 0.431753538233163 2032 3645418 SGTC_1503 4585-0012 61.3 µM 0.170893015350583 0.443623225095549 no 1484 0.432153944408619 2067 2922052 SGTC_387 norethindrone acetate 66.7 µM 0.170506667694726 0.443757627967296 no 1485 0.432305845541822 1978 541197 SGTC_2897 9048598 12.99 µM 0.17034617472368 0.443813462268434 no 1486 0.43236894984925 2007 6467404 SGTC_1039 k821-0043 94 µM 0.169664691986022 0.444050557412116 no 1487 0.432636921567282 2092 15992768 SGTC_877 0771-0151 33.1 µM 0.168540657404019 0.444441664798134 no 1488 0.433078980566361 2024 6166523 SGTC_2419 paclitaxel 166.5 µM 0.166865631895034 0.445024589530769 no 1489 0.433737887864565 1969 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1661 st013063 9.66 µM 0.166716813386131 0.445076385550132 no 1490 0.433796437760483 2025 721395 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.166360001830081 0.445200577000138 no 1491 0.433936824596867 2023 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_580 1123-0028 41 µM 0.166342992394134 0.445206497420693 no 1492 0.433943517135723 2098 1677248 YPR107C YTH1 SGTC_2581 avocatin a 64 µM 0.166216716189688 0.445250450361707 no 1493 0.433993202409045 2004 6710728 A skin care supplement. SGTC_2846 9008642 19.48 µM 0.163273614521976 0.446275044867065 no 1494 0.435151503836336 1982 2992898 SGTC_2429 5902844 64.44 µM 0.161220027364603 0.446990181848679 no 1495 0.435960053946339 2119 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1899 st063254 59.6 µM 0.160918208959364 0.44709530105811 no 1496 0.436078910265553 1953 3093813 SGTC_3099 9120367 49.47 µM 0.160095271869382 0.447381937617335 no 1497 0.436403012819528 2043 24824940 SGTC_2749 bexarotene 57.39 µM 0.158886278606312 0.447803090899952 no 1498 0.436879235724337 1982 82146 An retinoic acid receptor inhibitor. SGTC_495 decylubiquinone 155 µM 0.158793625298819 0.447835369150189 no 1499 0.43691573568023 1971 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1694 st024011 44.9 µM 0.15860989854231 0.447899376286241 no 1500 0.436988114808604 2117 2787533 SGTC_1005 4092-0690 4.4 µM 0.157262087168668 0.448368971183533 no 1501 0.437519149236563 1994 1529343 SGTC_74 000s-0487 160.283 µM 0.157145830130746 0.448409480036741 no 1502 0.437564959516002 2163 677548 SGTC_2912 7964298 10.93 µM 0.155333328652913 0.449041101269057 no 1503 0.438279271009249 2017 2975850 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.152616506330898 0.44998810200643 no 1504 0.439350353662425 2005 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2085 5307070 144.047 µM 0.152055430449903 0.450183711476444 no 1505 0.439571608353656 2000 2840351 SGTC_3128 9127691 49.47 µM 0.150607737503567 0.450688480547235 no 1506 0.440142578687826 2065 41316314 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.149411647088094 0.451105583233873 no 1507 0.440614410921141 2053 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2422 chlorphenesin carbamate 384.24 µM 0.149240887454581 0.451165135239233 no 1508 0.440681778859601 2018 2724 A muscle relaxant with antifungal properties. SGTC_3225 9130819 49.47 µM 0.148569865949799 0.451399162984951 no 1509 0.440946526276627 2118 4547121 SGTC_309 k408-0051 1.48 µM 0.147918447442112 0.451626370083334 no 1510 0.441203564702084 2055 3640463 SGTC_750 4073-0104 132 µM 0.147484021930719 0.451777901394357 no 1511 0.441374995234631 2138 22330957 SGTC_5 0352-0601 109.883 µM 0.14680285686096 0.452015511697128 no 1512 0.441643814834445 2057 762456 SGTC_1803 st050068 52.4 µM 0.145333313033168 0.452528190006436 no 1513 0.442223856968832 2147 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_440 fluspirilene 35.1 µM 0.143353007135406 0.453219182428221 no 1514 0.443005697220907 2094 3396 An atypical antipsychotic. SGTC_3293 9120939 62.045 µM 0.143311803811117 0.453233561105017 no 1515 0.443021966983301 2096 934087 SGTC_3204 9114183 49.47 µM 0.14294464753107 0.453361689915954 no 1516 0.443166948491614 1993 17027248 SGTC_87 0100-0052 35.5 µM 0.141540886033847 0.453851613950916 no 1517 0.44372133137894 2118 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2661 dactinomycin 12.96 µM 0.141250765423294 0.453952877155821 no 1518 0.443835921524255 2151 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_359 0081-0058 15.9 µM 0.140339559639655 0.454270942309216 no 1519 0.444195854758341 2125 3494159 SGTC_45 0kpi-0036 14.9 µM 0.140156927935738 0.45433469519865 no 1520 0.444268001221153 2066 2795021 SGTC_2195 6536160 144.242 µM 0.140077842778082 0.454362302530166 no 1521 0.444299243436699 2043 3834386 SGTC_2376 9072922 81.32 µM 0.139964634093916 0.454401822208812 no 1522 0.444343966591443 2093 17087968 SGTC_2681 menadione 3.18 µM 0.139358630510578 0.454613377840648 no 1523 0.444583380685827 2083 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1747 st037496 66.6 µM 0.13852896241228 0.454903035541671 no 1524 0.444911190789539 2089 723305 SGTC_2198 6589944 200 µM 0.138088487462332 0.455056826021036 no 1525 0.4450852421418 2116 5290268 SGTC_1012 4112-3522 18 µM 0.136888023192768 0.455475998572746 no 1526 0.445559652911884 2159 3112398 SGTC_1958 st076513 41.9 µM 0.13642268782705 0.455638495577085 no 1527 0.445743569527167 2068 732122 YGL099W LSG1 SGTC_1515 3460-0031 42.1 µM 0.13494614511785 0.456154159309277 no 1528 0.446327227339859 2105 2876596 SGTC_2097 5376186 200 µM 0.13235784398293 0.457058268205353 no 1529 0.447350628440487 2153 742755 SGTC_637 1181-0519 7.26 µM 0.131274365558086 0.457436799905511 no 1530 0.447779134802161 2152 6252091 YGR060W ERG25 SGTC_3332 9141069 11.198 µM 0.131227466208688 0.457453185868952 no 1531 0.447797684469737 2052 17332883 SGTC_950 1165-0508 94.1 µM 0.12977901771841 0.457959288577616 no 1532 0.44837063196925 2055 6148369 SGTC_1501 4491-0275 38.4 µM 0.127801515546565 0.458650357961859 no 1533 0.449153025334032 2204 5104718 SGTC_1254 0550-0035 264 µM 0.125640590116258 0.459405670353272 no 1534 0.450008215629199 2132 15121435 SGTC_1026 k007-1105 30.6 µM 0.125283303554499 0.459530567598487 no 1535 0.450149634933291 2138 7066794 SGTC_2996 9066192 71.4286 µM 0.12432640779068 0.459865090848256 no 1536 0.450528419557246 2055 6472854 SGTC_186 3455-3465 67.277 µM 0.121609506914483 0.460815052155227 no 1537 0.451604141974125 2168 755278 SGTC_214 4373-3496 70 µM 0.121302187060649 0.46092252037478 no 1538 0.45172584389407 2137 3779166 SGTC_587 k089-0003 57 µM 0.120632132263133 0.461156845078883 no 1539 0.451991208411396 2208 9659696 SGTC_2054 5233173 129 µM 0.119911925231227 0.461408723545468 no 1540 0.452276458836789 2109 6889 SGTC_127 0180-0333 59.125 µM 0.119329682922937 0.461612362842155 no 1541 0.452507083967795 2206 771601 SGTC_2369 9071472 200 µM 0.117214224161004 0.462352329047399 no 1542 0.453345147684726 2129 17296037 SGTC_109 0132-0036 33.701 µM 0.116758899218183 0.462511614264721 no 1543 0.453525557290731 2212 67274 A color developer. SGTC_2113 5491891 107.031 µM 0.115468554923138 0.462963044845761 no 1544 0.454036871635245 2106 789979 SGTC_420 mitomycin C 81.9 mM 0.11305193175102 0.46380863513839 no 1545 0.454994691747722 2093 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2247 cerulenin 830 nM 0.112425432191665 0.464027877767883 no 1546 0.455243045590938 2177 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1653 st012112 65 µM 0.111013172634626 0.464522135956117 no 1547 0.455802950523978 2201 720429 SGTC_2853 9015042 58.44 µM 0.110828018301821 0.464586939767011 no 1548 0.45587636341042 2162 6457456 SGTC_365 0121-0052 13.6 µM 0.109353615022034 0.465103012659621 no 1549 0.45646101144402 2166 3101739 SGTC_1616 st002734 56.1 µM 0.1093144751587 0.465116713258165 no 1550 0.456476532941082 2120 4026101 SGTC_201 4262-0159 12.803 µM 0.108910577691435 0.465258096773416 no 1551 0.456636708385199 2220 1341029 SGTC_1297 1068-0111 14.1 µM 0.107820002549304 0.465639872318708 no 1552 0.457069237823358 2138 767057 SGTC_48 0382-0018 55 µM 0.107677622078597 0.465689717518066 no 1553 0.457125710640415 2212 762596 SGTC_1058 3448-5425 97.3 µM 0.106493413897962 0.466104311258346 no 1554 0.457595440321765 2204 7279705 SGTC_2539 epi(13)torulosol 80 µM 0.105855925939707 0.466327512375606 no 1555 0.457848331762244 2110 6708597 SGTC_3116 9124943 49.47 µM 0.10573142799231 0.466371103583911 no 1556 0.457897722086716 2036 41905195 YPL160W CDC60 SGTC_972 1319-0219 195 µM 0.105647940816519 0.466400335672341 no 1557 0.457930843147203 2107 23903702 SGTC_1888 azatryptophan 97.5 µM 0.105628058377137 0.466407297309889 no 1558 0.457938730958327 2097 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_14 0354-0009 295 µM 0.102211472735217 0.467603731482202 no 1559 0.459294410762351 2188 1713507 SGTC_2894 9048625 32.47 µM 0.100815372529821 0.468092708518761 no 1560 0.459848511750964 2229 4092861 SGTC_725 1497-0963 19 µM 0.100724877442396 0.468124405634881 no 1561 0.459884431229431 2227 3549977 SGTC_176 1486-1328 72.834 µM 0.100377277373427 0.468246159090604 no 1562 0.460022404337077 2148 22310231 SGTC_1021 4476-0760 85.3 µM 0.0992665443571513 0.468635234054777 no 1563 0.46046332046019 2061 746768 SGTC_97 0535-0701 19.132 µM 0.0992169110495682 0.468652620642576 no 1564 0.460483024016418 2228 2832013 YGL099W LSG1 SGTC_1771 st048882 4.1505 µM 0.0988902771354053 0.468767042256777 no 1565 0.460612694393601 2121 4580403 SGTC_2499 avocadenofuran 51.48 µM 0.0987782796695831 0.468806276164924 no 1566 0.460657157225567 2222 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2705 st078069 42.8 µM 0.0982929457973195 0.468976297298447 no 1567 0.460849839748216 2154 1530061 SGTC_2254 7938975 95.19 µM 0.0974828342456402 0.469260106448726 no 1568 0.461171482793786 2221 2969277 SGTC_691 1548-0686 185 µM 0.0958044668427762 0.469848144180254 no 1569 0.461837934826978 2148 46495133 SGTC_2676 harmalol 100 µM 0.0949726015724177 0.470139623395223 no 1570 0.462168294653901 2218 5459187 A monoamine oxidase inhibitor SGTC_986 1493-0483 84 µM 0.094281123021687 0.470381924364386 no 1571 0.462442922380109 2233 40079 SGTC_1105 epirubicin 18.1 µM 0.0897171154408033 0.471981468943951 no 1572 0.464256007318413 2146 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1392 3455-1037 33.9 µM 0.0886703279527222 0.472348400490643 no 1573 0.464671957243052 2211 981132 SGTC_89 0302-0250 142.109 µM 0.0871715502213022 0.472873809443723 no 1574 0.465267576443451 2272 4203518 YLR208W SEC13 SGTC_3294 9122953 26.2835 µM 0.0870182516943764 0.472927552188758 no 1575 0.465328502191746 2251 16459826 SGTC_3232 9132874 49.47 µM 0.086593030954943 0.473076626841926 no 1576 0.465497502792661 2146 3784940 SGTC_545 4218-0007 221 µM 0.0865702076092405 0.473084628398413 no 1577 0.465506573926125 2181 2840508 SGTC_669 0108-0021 26.2 µM 0.0847038562586486 0.47373898241591 no 1578 0.466248415068614 2295 17201 SGTC_1180 1193-0155 285 µM 0.083137002535372 0.474288385553454 no 1579 0.466871301952637 2171 2921347 SGTC_682 0kpi-0099 17 µM 0.0830702572630001 0.474311790275045 no 1580 0.466897837674733 2154 1714895 YML126C ERG13 SGTC_679 0422-0091 41.4 µM 0.0816100957212178 0.474823828724442 no 1581 0.467478386426432 2230 627384 YHR062C RPP1 SGTC_2397 5161689 200 µM 0.0809798185948387 0.475044862458292 no 1582 0.467729001106676 2221 2259942 SGTC_705 1124-0212 310 µM 0.0809254093681588 0.475063943750675 no 1583 0.467750636240331 2270 9554485 SGTC_2316 5844804 197.44 µM 0.0806482974189667 0.475161127678545 no 1584 0.467860827742289 2257 776813 SGTC_60 0986-0278 202 µM 0.0800746793593042 0.47536230180956 no 1585 0.468088930505288 2047 3110598 SGTC_136 0097-0015 404.482 µM 0.0794569234290542 0.475578962598135 no 1586 0.468334596680749 2264 4861337 SGTC_1738 st035555 74 µM 0.0790097265821723 0.475735809019986 no 1587 0.468512443278732 2212 5331140 SGTC_2330 7979373 200 µM 0.0776399068542987 0.476216272469929 no 1588 0.469057248547229 2194 1863007 SGTC_2958 9077254 16.72 µM 0.0775345461208725 0.476253229125237 no 1589 0.469099155074463 2180 16457351 SGTC_2128 5255449 168.493 µM 0.0747246277904649 0.477238919098139 no 1590 0.470216906153753 2249 736008 SGTC_2400 5203494 178.7 µM 0.0744060064544395 0.477350697035335 no 1591 0.470343664797151 2270 6777674 SGTC_175 3793-3120 23.7 µM 0.0744046836931437 0.477351161086852 no 1592 0.470344191043849 2214 5322297 SGTC_821 1114-0266 29.2 µM 0.0742700467632042 0.477398394615806 no 1593 0.470397755204064 2205 3123235 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.0733928084739192 0.477706156407441 no 1594 0.470746770085001 2219 803109 SGTC_454 lyso-paf C-16 6.67 µM 0.0725208532958753 0.478012077899861 no 1595 0.47109370531552 2184 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_470 aa-861 153 µM 0.0716302484054032 0.478324555932389 no 1596 0.471448083576141 2179 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_841 0251-0215 91.2 µM 0.0663933724264648 0.48016223181946 no 1597 0.473532323299887 2225 3888614 SGTC_1334 1486-0610 236 µM 0.0662515183856848 0.48021201596455 no 1598 0.473588790547382 2235 3742339 SGTC_168 3970-0862 530.542 µM 0.066187086110255 0.480234628786841 no 1599 0.473614439010374 2225 3135186 SGTC_451 chloral hydrate 100 µM 0.0660976622065507 0.48026601264873 no 1600 0.473650036036028 2199 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_850 0388-0143 75.9 µM 0.0660387536262529 0.480286687039459 no 1601 0.473673485924018 2183 67273 SGTC_1612 st002233 45.4 µM 0.0656793144300305 0.480412835962233 no 1602 0.473816570770137 2291 1035021 SGTC_1724 st037281 8.293 µM 0.0652229899465898 0.480572990608235 no 1603 0.473998228384298 2249 574124 YDL195W SEC31 SGTC_1676 st018489 23.4 µM 0.0651799246094106 0.480588105264935 no 1604 0.474015372487596 2134 3696235 SGTC_2913 7966556 36.57 µM 0.0651472654504802 0.480599567680165 no 1605 0.474028373973544 2284 2976516 SGTC_2806 7952793 58.44 µM 0.0649236149883996 0.480678062920335 no 1606 0.474117409107594 2246 2972490 SGTC_646 4092-0839 27.3 µM 0.0641554457311196 0.480947675161232 no 1607 0.474423226712785 2258 877796 SGTC_754 3474-0146 171 µM 0.0614990626002892 0.481880079587772 no 1608 0.475480880465792 2264 24762078 SGTC_2038 4100038 30.985 µM 0.0609841359737368 0.48206083316571 no 1609 0.475685921598598 2246 3596803 SGTC_3295 9122362 53.5725 µM 0.0604717338005956 0.482240704250881 no 1610 0.475889963898738 2219 4730473 SGTC_3067 9117431 49.47 µM 0.059586804039921 0.482551354041091 no 1611 0.476242364271946 2241 17150885 SGTC_2217 6934799 96.0675 µM 0.0591693884168165 0.482697889218948 no 1612 0.476408595706912 2293 675606 SGTC_1134 3477-0009 42.5 µM 0.0589206960704337 0.482785194627544 no 1613 0.476507636803551 2306 3973534 SGTC_1278 0874-0585 172 µM 0.0570190949163162 0.483452793684345 no 1614 0.477264992171085 2257 766306 SGTC_1354 1498-1681 81 µM 0.0563338346723326 0.483693380887272 no 1615 0.47753793272515 2228 5754243 SGTC_372 0155-0182 15.9 µM 0.0560011188410606 0.483810195838807 no 1616 0.477670457927744 2229 771486 SGTC_2088 5278280 127.392 µM 0.0556729011747494 0.483925432867568 no 1617 0.477801193870079 2253 791502 SGTC_1519 esterone 74 µM 0.0543707307262089 0.484382637279847 no 1618 0.47831989892325 2246 698 A steroid. SGTC_2370 9071495 200 µM 0.053981687953161 0.484519237903602 no 1619 0.478474876931357 2171 21791103 SGTC_1928 4'-methoxychalcone 40.3 µM 0.053168404092018 0.484804803826862 no 1620 0.478798864937763 2326 641818 SGTC_2856 9022925 19.48 µM 0.0528473012035952 0.48491755387523 no 1621 0.478926786610228 2249 4944862 SGTC_2389 9091542 195.52 µM 0.0515434117708943 0.485375405704378 no 1622 0.47944625510663 2193 3626624 YOL127W RPL25 SGTC_1447 4239-0816 81.9 µM 0.0513575341154923 0.485440676952125 no 1623 0.479520311478144 2209 1341554 SGTC_523 1934-0222 13.7 µM 0.0507844747283311 0.485641910156225 no 1624 0.479748631142407 2307 1361595 SGTC_1693 xanthone 101.9 µM 0.0496592727540308 0.486037042096254 no 1625 0.480196956012964 2247 7020 An insecticide. SGTC_1995 st072814 61.1 µM 0.049186903982022 0.486202925747265 no 1626 0.480385173871488 2194 5769371 SGTC_1292 0kpi-0043 232 µM 0.0483254993065239 0.48650543483518 no 1627 0.4807284163915 2269 3333905 SGTC_1641 st009299 47.1 µM 0.0467101908663387 0.487072721513949 no 1628 0.481372104038063 2329 4046054 SGTC_2408 sulbentine 18.36 µM 0.0445218963083966 0.487841279002555 no 1629 0.482244199275105 2196 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_626 0214-0009 33 µM 0.0439007077333187 0.488059456855953 no 1630 0.482491775578377 2299 3437874 SGTC_1897 st060201 15 µM 0.0436999468087877 0.488129970168514 no 1631 0.48257179080911 2205 611878 SGTC_1663 st014140 55.4 µM 0.0395300070440853 0.489594659823939 no 1632 0.484233915022887 2344 4207120 SGTC_3244 9134489 49.47 µM 0.037454637680862 0.490323686008404 no 1633 0.485061254316563 2254 16584271 SGTC_2190 6049624 200 µM 0.0370050189712418 0.49048163034058 no 1634 0.48524050196132 2318 2265554 SGTC_806 3966-4455 5.86 µM 0.0355930296435664 0.490977650674672 no 1635 0.485803433170207 2200 714982 SGTC_3281 9140613 49.47 µM 0.0354928044152187 0.491012859519284 no 1636 0.485843392003392 2196 16013766 SGTC_918 glabranin 770.725 nM 0.0353160266255997 0.491074961236761 no 1637 0.485913871951626 2306 124049 Also referred to as licorice root. SGTC_442 cape 100 µM 0.0348533089703179 0.491237514131838 no 1638 0.486098356007773 2337 5281787 SGTC_389 tpck 16.7 µM 0.0341518001505316 0.491483957224023 no 1639 0.486378051002638 2310 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2593 nobiletin 86.24 µM 0.0333075879573784 0.491780536931975 no 1640 0.486714651401823 2315 72344 An anti-infammatory. SGTC_141 0443-0274 32.331 µM 0.0327814272072479 0.491965384476414 no 1641 0.48692444459691 2341 1627241 SGTC_988 1497-1057 103 µM 0.0302207782686324 0.492864999744476 no 1642 0.487945488718291 2346 3533044 SGTC_3012 9080433 71.4286 µM 0.0290392197065134 0.493280121141472 no 1643 0.488416655485362 2353 17688859 SGTC_2457 5731572 11.68 µM 0.028556481087752 0.493449725628783 no 1644 0.48860916048859 2360 2865357 SGTC_1235 benzylparaben 21.5 µM 0.0276637352922426 0.493763384370934 no 1645 0.488965173835472 2320 7180 SGTC_1893 st059353 36.1 µM 0.0276434730984012 0.493770503368156 no 1646 0.488973254191086 2235 3112488 SGTC_759 3486-0358 89.3 µM 0.0274334936833455 0.493844278460959 no 1647 0.489056992099514 2367 875103 SGTC_1810 st050138 53 µM 0.0272660882957658 0.49390309555834 no 1648 0.489123752213187 2361 3444541 SGTC_17 0960-0276 49.807 µM 0.0268292132798192 0.494056590166237 no 1649 0.489297976386196 2355 6821114 SGTC_2151 5563267 85.4165 µM 0.024582328332363 0.494846039248627 no 1650 0.490194057494371 2329 5310824 SGTC_2991 9074669 71.4286 µM 0.0245143825035744 0.494869912528702 no 1651 0.490221155792004 2358 17333109 SGTC_2385 9074692 200 µM 0.0243352671845726 0.494932846136553 no 1652 0.490292591154377 2347 17046906 SGTC_3085 9117376 49.47 µM 0.0230266627648048 0.495392638550299 no 1653 0.49081450238719 2266 16480349 SGTC_2567 aureobasidin a 60 nM 0.0230052428064653 0.495400164738506 no 1654 0.49082304545114 2302 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_726 3448-4391 34.2 µM 0.0229906899056284 0.495405278095355 no 1655 0.490828849683436 2337 1356692 SGTC_3179 9107801 49.47 µM 0.0229024617250388 0.495436278265787 no 1656 0.490864038369545 2370 4818259 SGTC_820 1582-0060 59.9 µM 0.0216830781943237 0.495864727983564 no 1657 0.49135038112254 2347 3848840 SGTC_1545 lovastatin 49.4 µM 0.0213952086560536 0.495965876219837 no 1658 0.491465197815386 2353 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1788 fluconazole 20 µM 0.019036782085925 0.496794561782457 no 1659 0.492405881429493 2278 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1135 dihydrocapsaicin 536.708 nM 0.0185298838613632 0.496972673661342 no 1660 0.492608068890578 2367 107982 A Capsaicinoid. SGTC_3130 9127414 49.47 µM 0.0182507849738778 0.497070742576492 no 1661 0.492719394409866 2380 1494646 SGTC_2874 9043904 71.43 µM 0.0179672391578094 0.497170374221071 no 1662 0.49283249427765 2292 4463428 SGTC_417 st075190 100 µM 0.016378574795388 0.497728598359111 no 1663 0.493466186147035 2380 222757 SGTC_1514 1189-1591 158 µM 0.015827491717139 0.497922238767022 no 1664 0.493686007981588 2375 767698 YMR146C TIF34 SGTC_1565 sinapyl alcohol 95.1 µM 0.0157571420438814 0.497946958378106 no 1665 0.493714069941151 2362 5280507 A phenol propionate derived from cinnamic acid. SGTC_1734 st037168 69.4 µM 0.015053938126289 0.498194052016582 no 1666 0.493994574421711 2299 708907 SGTC_1791 st048313 56.1 µM 0.0150067825949644 0.498210621676803 no 1667 0.494013384632066 2379 1204976 SGTC_2426 5582046 32.21 µM 0.0149813221249331 0.498219568058835 no 1668 0.494023540748319 2374 2251934 SGTC_413 propylparaben 100 µM 0.0149612564794175 0.498226618790668 no 1669 0.494031544885626 2363 7175 A pharmaceutical preservative. SGTC_1917 st066507 28.5 µM 0.011773212332317 0.499346849683361 no 1670 0.495303276325739 2342 3156428 SGTC_2180 6301957 200 µM 0.0117534654744277 0.499353788458188 no 1671 0.495311153637221 2376 845462 SGTC_1883 5-benzylidenerhodanine 20 µM 0.0117424315941602 0.499357665612353 no 1672 0.495315555214826 2385 1273210 SGTC_1186 1319-0216 26 µM 0.0109295896525724 0.499643287262704 no 1673 0.495639811388721 2392 4565136 SGTC_2233 sulbentine 40.3845 µM 0.0108369594228164 0.499675836285344 no 1674 0.495676763315338 2370 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_3235 9132602 49.47 µM 0.010287534225614 0.499868896981195 no 1675 0.49589594002753 2364 4912240 SGTC_824 1304-0008 100 µM 0.00954133064947043 0.499868896981195 no 1676 0.496193617546324 2378 768245 SGTC_1892 st058411 7.36 µM 0.00918903878518454 0.499745106306302 no 1677 0.496334155502109 2391 3934738 SGTC_2000 st075254 36.4 µM 0.00906174299537675 0.499700376264475 no 1678 0.496384937060341 2387 17234175 SGTC_921 1561-0023 372 µM 0.00736796970180012 0.499105207509859 no 1679 0.49706063196016 2396 24050882 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.00719712063291323 0.499045173573798 no 1680 0.497128789069828 2313 61125 An anti-inflammatory. SGTC_3200 9114385 49.47 µM 0.00685035316821828 0.498923324480116 no 1681 0.497267125859951 2380 17018030 YLR208W SEC13 SGTC_2086 5274770 176.623 µM 0.00531942310320188 0.498385379055709 no 1682 0.497877867224864 2391 689278 SGTC_395 anisomycin 6.25 µM 0.00509346205061174 0.49830598002077 no 1683 0.497968011420495 2388 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1033 k072-0102 21.3 µM 0.00476114783564831 0.498189210338946 no 1684 0.498100584001282 2397 5965931 SGTC_278 4092-0821 23.9 µM 0.00439338703617063 0.498059985498795 no 1685 0.498247297795505 2381 877900 SGTC_1312 1218-2183 165 µM 0.00428097158668907 0.49802048467706 no 1686 0.498292144649438 2399 6744073 SGTC_1607 st000305 50.6 µM 0.0034460114752865 0.497727094938638 no 1687 0.498625243044632 2400 5457690 SGTC_3181 9108277 49.47 µM 0.00337577672312573 0.49770241578292 no 1688 0.498653262493825 2393 17097298 SGTC_245 methotrexate 289.6 µM 0.00331721015767678 0.497681836612748 no 1689 0.498676627042166 2364 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_3091 9116372 49.47 µM 0.00307712907889118 0.497597476781727 no 1690 0.498772405045471 2366 17169793 SGTC_1932 st074806 40.9 µM 0.00236770058997681 0.497348198023117 no 1691 0.499055425009876 2384 17251235 SGTC_2424 5537928 59.2 µM 0.00213397184234283 0.497266070711502 no 1692 0.49914866905304 2400 5382802 SGTC_1029 k015-0030 64.7 µM 0.00143664633619799 0.497021046059643 no 1693 0.499426861231662 2393 2208316 SGTC_67 0335-0847 266 µM 0.00126595744366892 0.496961069952089 no 1694 0.499494956185433 2401 4552207 YOR254C SEC63 SGTC_1472 k841-0093 193 µM -0.00176395084154297 0.49589644333048 no 1695 0.499296285793696 2414 X1472 SGTC_1632 st005650 90 µM -0.00217536681893968 0.495751885131679 no 1696 0.499132154885015 2413 2759605 SGTC_1084 voriconazole 435 nM -0.00332392254958568 0.495348323001292 no 1697 0.498673949199994 2413 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2131 toluylene red 5.2905 µM -0.00387570626876534 0.495154447256146 no 1698 0.498453820773859 2414 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_459 nigericin 15.3 µM -0.00428616572278839 0.495010228205225 no 1699 0.498290072507949 2420 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2974 9094440 9.66 µM -0.00492276063063317 0.494786555488708 no 1700 0.498036110580157 2440 25236134 SGTC_940 3232-1287 54.8 µM -0.00512723195207324 0.494714713197609 no 1701 0.497954539354915 2415 1585493 YIL048W NEO1 SGTC_1600 coumarin 106 71.1 µM -0.00531111726687251 0.494650104076386 no 1702 0.497881180727343 2444 100336 A hepatotoxic, DNA x-linker. SGTC_1118 chelidonine 707.474 nM -0.00622059124735827 0.494330557465202 no 1703 0.497518359147172 2418 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_586 0957-0265 8.15 µM -0.00662779924686641 0.494187484790338 no 1704 0.497355910012568 2414 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_517 1365-0151 113 µM -0.00690517518131372 0.494090029084506 no 1705 0.497245255558312 2437 768657 SGTC_69 0096-0274 206.684 µM -0.0072285383602421 0.493976416260531 no 1706 0.497116255536075 2490 6741392 SGTC_2130 NSC 7 2.4545 µM -0.00838718686098927 0.493569332156992 no 1707 0.496654035776158 2425 21448 SGTC_558 k064-0027 21.3 µM -0.00857183738347843 0.49350445692671 no 1708 0.496580373524028 2424 5088526 SGTC_552 k242-0005 476 µM -0.00871440304255492 0.493454367936152 no 1709 0.496523500179296 2436 4088318 SGTC_344 k064-0035 6.43 µM -0.00939963125259677 0.493213621445979 no 1710 0.496250144891771 2423 5088750 SGTC_2405 ticlatone 3.52 µM -0.00999241715914307 0.493005355411263 no 1711 0.496013668650054 2416 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2980 9014342 25.29 µM -0.0100967382811462 0.492968704016248 no 1712 0.495972052643213 2466 2996599 SGTC_1789 tunicamycin 25 nM -0.0113750177096089 0.492519607891412 no 1713 0.495462122355642 2444 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1266 0828-0227 32.9 µM -0.0115041093552855 0.492474254821607 no 1714 0.495410625609806 2440 3913820 SGTC_1389 3405-0187 19 µM -0.0119300622231624 0.492324607797184 no 1715 0.495240706667131 2443 799890 SGTC_1413 3910-0535 34.4 µM -0.0131789018515204 0.49188586806087 no 1716 0.494742531031837 2441 2876951 SGTC_1038 k292-0204 154 µM -0.0136029663253654 0.49173688881945 no 1717 0.494573368952379 2415 4454212 SGTC_289 k017-0060 526 µM -0.0142833111685137 0.491497877442592 no 1718 0.494301977016515 2443 5512909 SGTC_668 1682-0499 62.6 µM -0.0157172925719717 0.490994116738511 no 1719 0.493729965611863 2453 682214 SGTC_236 1509-0011 5.31 µM -0.0173137820253557 0.490433283546545 no 1720 0.493093145392725 2434 3107280 SGTC_464 bw-b 70c 158 µM -0.0175288709088725 0.490357726068965 no 1721 0.493007350363707 2471 5353454 SGTC_2340 7987427 183.45 µM -0.0176799276541695 0.490304662321515 no 1722 0.49294709677879 2455 2239331 SGTC_828 2074-0507 139 µM -0.0180407550005074 0.49017791031208 no 1723 0.49280317045268 2466 X828 SGTC_1252 0493-0875 34.8 µM -0.0184615160273162 0.490030105956764 no 1724 0.492635339045359 2445 3960963 SGTC_2411 st077133 39.94 µM -0.0188370506741903 0.489898189817664 no 1725 0.492485548448378 2513 1403142 YNL221C POP1 SGTC_1257 0669-0121 16 µM -0.0189486371634514 0.48985899242473 no 1726 0.492441039824067 2468 4307855 SGTC_210 3551-0445 56.827 µM -0.0190515951054217 0.489822826099927 no 1727 0.492399972961258 2442 2865180 YOR207C RET1 SGTC_1587 estradiol valerate 56.1 µM -0.0195272428835806 0.489655745062835 no 1728 0.492210252252843 2453 13791 A steroid. SGTC_2437 5741531 144.16 µM -0.0203991622317838 0.489349470244364 no 1729 0.491862476077189 2446 2262990 SGTC_1071 trifluoperazine 6.31 µM -0.0213394682461386 0.48901918062185 no 1730 0.49148742994586 2475 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_3335 9143315 29.6265 µM -0.0230803603606573 0.488407699103243 no 1731 0.490793085837674 2458 4899691 SGTC_62 0180-0423 3.232 µM -0.0238117375535353 0.488150813781989 no 1732 0.490501388745489 2470 30102 YGL099W LSG1 SGTC_1341 1486-1360 280 µM -0.0242449989972194 0.487998639479228 no 1733 0.490328592328772 2453 3976547 SGTC_1511 0906-3109 28.5 µM -0.0243250186544557 0.487970534386582 no 1734 0.490296678516404 2440 2882180 SGTC_1247 0448-0043 5.84 µM -0.0257253466731685 0.487478710673141 no 1735 0.489738203411552 2482 3089013 YGL099W LSG1 SGTC_704 1310-0270 142 µM -0.0268067560220504 0.487098910682341 no 1736 0.489306932314671 2487 5718033 SGTC_532 1548-0774 215 µM -0.0285176487856114 0.486498054896919 no 1737 0.488624646029041 2494 5932993 SGTC_578 3460-0051 92 µM -0.0287883578031514 0.486402986206596 no 1738 0.488516693080078 2456 2876744 SGTC_1373 2887-0003 58.5 µM -0.0292346968644684 0.486246240735354 no 1739 0.488338704478084 2497 776948 SGTC_1708 st033234 31.827 µM -0.0294007042949315 0.486187942742234 no 1740 0.488272505551303 2518 674664 SGTC_1956 st077085 54 µM -0.0301387363093538 0.485928766456492 no 1741 0.487978203822464 2483 24208685 SGTC_1157 4092-0394 27.6 µM -0.0320753583455818 0.485248707283933 no 1742 0.487205977243976 2548 3659885 SGTC_556 4058-0063 51.5 µM -0.0328139574190501 0.484989353942263 no 1743 0.486911473898125 2476 6615692 SGTC_1559 coumarin 343 70.1 µM -0.0341426026483427 0.484522826523489 no 1744 0.486381718136516 2498 108770 A hepatotoxic, DNA x-linker. SGTC_602 3130-1533 38.1 µM -0.0342106380695261 0.484498937799583 no 1745 0.486354591777428 2507 720941 SGTC_2833 9001315 45.46 µM -0.0343665945547194 0.484444178277873 no 1746 0.48629241070582 2507 2989378 SGTC_2723 salbutamol 83.58 µM -0.0347783578455776 0.484299601150876 no 1747 0.486128239063641 2466 9884233 β2-adrenoceptor agonist SGTC_767 0929-0023 86 µM -0.0357911229309751 0.48394401084599 no 1748 0.485724455704206 2474 1204563 SGTC_1212 0520-0165 585 µM -0.0364546600846624 0.483711044299358 no 1749 0.485459915334657 2517 5403258 SGTC_899 1083-0020 478 µM -0.0379220864551161 0.483195853742967 no 1750 0.484874901634148 2529 767123 SGTC_196 k015-0023 18.111 µM -0.0386635158026929 0.482935560055241 no 1751 0.484579330909078 2469 5211998 SGTC_2245 6637752 200 µM -0.0391972551579887 0.482748184613383 no 1752 0.484366561011525 2483 681890 SGTC_1989 st071868 50.2 µM -0.0393535501616713 0.482693316144163 no 1753 0.484304256399157 2476 16414057 SGTC_2166 5933061 31.504 µM -0.0396050198916507 0.482605036600853 no 1754 0.484204012642997 2590 2877375 SGTC_536 3852-0578 10.6 µM -0.0397705057595188 0.482546942531626 no 1755 0.48413804530722 2471 2869208 SGTC_393 acivicin 6.25 µM -0.0400982425981772 0.482431891103632 no 1756 0.484007401439992 2500 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1936 st074407 74.3 µM -0.0402974353514362 0.482361965559915 no 1757 0.483927999206516 2474 809813 SGTC_1908 st060353 56.5 µM -0.0405503385438841 0.482273186037697 no 1758 0.483827187831589 2498 4227716 SGTC_2284 7945075 39.21 µM -0.0409091867976559 0.482147216909217 no 1759 0.483684146787262 2520 1245402 SGTC_1047 2043-3044 82 µM -0.0413278063679999 0.482000268071333 no 1760 0.483517282863091 2480 669592 SGTC_1749 st037932 54.2 µM -0.0430079916698554 0.481410494179718 no 1761 0.482847581659206 2548 594497 SGTC_3194 9111903 49.47 µM -0.0432285353126342 0.481333082566978 no 1762 0.482759679227023 2554 17087251 SGTC_290 2043-6722 48.1 µM -0.0433791873547371 0.481280203562188 no 1763 0.482699634083318 2515 773758 YLR208W SEC13 SGTC_151 3013-0144 2.285 µM -0.0436790717033429 0.481174944862378 no 1764 0.482580110826975 2611 906558 YHR107C CDC12 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.0438345467264173 0.481120374011721 no 1765 0.482518144617252 2473 5711223 A potent inhibitor of glutathione S-transferases. SGTC_737 1950-0117 57.9 µM -0.0439909928526556 0.481065462666474 no 1766 0.482455791790401 2469 5393513 SGTC_1520 flindersine 88 µM -0.0451647758455664 0.480653485708777 no 1767 0.481987985194108 2574 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1884 5633444 25 µM -0.0452991986165981 0.4806063070169 no 1768 0.481934413097826 2540 5724239 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.045570746650573 0.48051100196224 no 1769 0.481826192865414 2565 5282309 SGTC_1002 4049-0206 172 µM -0.0457529602260393 0.480447051194455 no 1770 0.481753575909025 2503 4662749 SGTC_3227 9130768 49.47 µM -0.0468245327076223 0.480070975934323 no 1771 0.48132653810103 2497 17720899 SGTC_2118 5526350 200 µM -0.0518647644613716 0.478302317627749 no 1772 0.479318225178469 2594 743594 SGTC_2452 5863136 48.41 µM -0.0539562029914089 0.477568538264033 no 1773 0.478485029164407 2495 2184096 SGTC_150 3970-0969 77.2 µM -0.0540117351409667 0.477549055883673 no 1774 0.478462907300057 2634 6615640 SGTC_955 1216-0110 33 µM -0.0544750619135578 0.477386508744732 no 1775 0.478278338395126 2493 3619719 SGTC_2141 5621638 7.665 µM -0.0548178900852421 0.477266238083897 no 1776 0.478141773802644 2584 2856238 SGTC_2279 7948423 32.93 µM -0.0550650529078259 0.477179529935913 no 1777 0.478043318811425 2490 1247112 SGTC_2896 9052656 71.43 µM -0.0551087016479575 0.477164217464296 no 1778 0.478025931884397 2501 6469436 SGTC_2766 oltipraz 83.91 µM -0.0551567849839762 0.477147349325325 no 1779 0.478006778540248 2533 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_3065 9113888 49.47 µM -0.0560555868511252 0.476832047765025 no 1780 0.47764876241536 2577 16648368 SGTC_1382 3002-2117 298 µM -0.0579950071154377 0.476151744782893 no 1781 0.476876302789689 2501 1497314 SGTC_1770 st043884 66.3 µM -0.0594108466727153 0.47565514537068 no 1782 0.476312436962821 2515 670149 SGTC_2119 5528445 120.635 µM -0.059645977944847 0.47557267776592 no 1783 0.476218799213062 2584 791935 SGTC_2265 7929201 200 µM -0.061670369300068 0.474862706525478 no 1784 0.475412668456212 2498 1265108 SGTC_2531 methyl deoxycholate 70.07 µM -0.061767233301886 0.474828737480403 no 1785 0.475374098840345 2527 16667744 Haematoxylin. SGTC_1057 3448-5381 134 µM -0.0629778114761495 0.474404217729648 no 1786 0.474892086558548 2587 5497911 SGTC_2434 5670830 169.91 µM -0.0630148126929453 0.474391242775571 no 1787 0.474877354470171 2583 1549830 SGTC_1596 piperlongumine 63 µM -0.0630525283660796 0.474378017316116 no 1788 0.474862337955313 2523 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.065375416760403 0.47356352324063 no 1789 0.473937548390985 2588 7104 SGTC_2161 5662504 8.5105 µM -0.0654539046064658 0.473536004291795 no 1790 0.473906303192584 2555 2859334 SGTC_2365 9042475 200 µM -0.0672339339853854 0.47291193498205 no 1791 0.473197735409575 2570 6464479 SGTC_2243 6634756 200 µM -0.0676519816697695 0.472765379159372 no 1792 0.473031337380011 2698 885676 SGTC_3228 9131799 49.47 µM -0.067985487824252 0.472648463874764 no 1793 0.472898593296404 2566 17015818 SGTC_324 1315-0088 19.6 µM -0.0682164975463794 0.472567481540452 no 1794 0.472806647209924 2508 6787421 SGTC_659 k018-0002 107 µM -0.0693832665445572 0.472158478587713 no 1795 0.472342274090328 2548 6797879 YHR007C ERG11 SGTC_2606 farnesol 9.78 µM -0.0700356669813593 0.471929796811896 no 1796 0.472082635588866 2566 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1234 0326-0494 15.5 µM -0.0717901834238156 0.471314843437704 no 1797 0.471384442578096 2627 1547813 SGTC_1821 st053465 65.6 µM -0.0721590525852526 0.471185564423166 no 1798 0.471237665744645 2582 675086 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.0724461875979394 0.471084933195699 no 1799 0.47112341447283 2618 6708760 SGTC_1809 st050081 57.6 µM -0.0732248867143545 0.47081203448635 no 1800 0.470813581404924 2639 5036894 SGTC_2988 9073640 71.4286 µM -0.0745721914525972 0.470339897751212 no 1801 0.470277550252201 2628 9102229 SGTC_2083 5306046 65.942 µM -0.0750444113933236 0.470174427292834 no 1802 0.470089688154699 2558 539837 SGTC_887 0885-0007 9.62 µM -0.0754043871768415 0.470048291736291 no 1803 0.469946484343673 2678 5719458 SGTC_648 0375-0473 33.3 µM -0.0757663580560006 0.46992146012845 no 1804 0.469802490772871 2550 1713139 SGTC_1966 st070145 16.1 µM -0.0778127741763461 0.469204470582662 no 1805 0.468988492468588 2528 3748532 SGTC_930 2810-3379 265 µM -0.0780067105867974 0.469136527483774 no 1806 0.46891135749235 2587 1015764 SGTC_778 3456-2434 196 µM -0.0781676492511626 0.469080145398334 no 1807 0.46884734770573 2711 5539063 SGTC_1950 st077106 7.18 µM -0.0785909457272527 0.468931853741402 no 1808 0.468678994763069 2614 13831864 SGTC_3103 9120822 49.47 µM -0.0787731818656045 0.4688680130549 no 1809 0.468606517757904 2601 17141819 SGTC_2357 9067248 200 µM -0.0802483398720212 0.468351267555691 no 1810 0.468019872220937 2609 9150235 SGTC_2027 5150920 200 µM -0.0806550765012137 0.46820879770293 no 1811 0.467858132061321 2613 786715 SGTC_1330 1469-0054 61.8 µM -0.0809943002338068 0.468089979073054 no 1812 0.467723242684071 2604 7102664 SGTC_1291 0993-0025 5.79 µM -0.0816458552731625 0.467861769305398 no 1813 0.467464167878221 2619 4353356 SGTC_2123 5259487 200 µM -0.0827925192030017 0.467460171357116 no 1814 0.467008258758892 2596 2173474 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.0837444942634391 0.467126784747833 no 1815 0.466629790032396 2664 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2464 5717415 7.67 µM -0.0839778536743287 0.467045064580681 no 1816 0.466537019883434 2561 5285744 SGTC_1955 wogonin 32.4 µM -0.084433085556721 0.466885650860555 no 1817 0.46635605136254 2785 5281703 A flavanone. SGTC_382 3229-0966 23.2 µM -0.085223181263814 0.466608986694941 no 1818 0.466041980819134 2638 5722370 SGTC_1185 1319-0113 81.3 µM -0.0860670850415078 0.466313498627823 no 1819 0.465706544418156 2634 4672763 SGTC_1725 st036284 20.55 µM -0.0880020759745445 0.465636043011328 no 1820 0.464937513078425 2698 707914 SGTC_1767 st044992 70.3 µM -0.0887464044135427 0.465375474153943 no 1821 0.464641726306856 2597 9600693 SGTC_1321 1326-2144 215 µM -0.0890810287913517 0.465258336218748 no 1822 0.464508757139077 2657 3513030 SGTC_978 1416-0512 87.4 µM -0.0893167069293708 0.465175837010948 no 1823 0.464415108462453 2601 6814003 SGTC_796 1234-0020 70.7 µM -0.0893574165531781 0.465161586745584 no 1824 0.464398932352928 2554 46495034 SGTC_3114 9122766 49.47 µM -0.0893899079626337 0.465150213270263 no 1825 0.464386021821463 2631 17176985 SGTC_1961 st076550 68.7 µM -0.0906675622283086 0.464702998664725 no 1826 0.463878373014587 2659 1579337 SGTC_836 0330-0104 1.35 µM -0.0908254254660669 0.464647745214581 no 1827 0.463815653472376 2575 46494820 SGTC_1968 st069590 43.6 µM -0.091061036055886 0.464565280810922 no 1828 0.463722046344982 2622 6384066 SGTC_2069 5228469 200 µM -0.0913839671170468 0.46445225645729 no 1829 0.463593750413827 2656 2835210 SGTC_857 0438-0306 1.35 µM -0.0918333668239927 0.464294973447276 no 1830 0.463415216586488 2629 4686136 SGTC_228 caffeine 993.056 µM -0.0921714078197812 0.464176667955009 no 1831 0.463280927287576 2615 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_997 3996-0078 137 µM -0.093576047763006 0.46368511481525 no 1832 0.462722968612075 2617 735687 SGTC_125 0133-0007 11.75 µM -0.093671970718289 0.463651548632131 no 1833 0.462684868239575 2659 26541 SGTC_2815 7968870 71.43 µM -0.0942008585529555 0.463466480318223 no 1834 0.462474801390949 2580 2977326 YHR190W ERG9 SGTC_1764 st044502 93.5 µM -0.0945258858356268 0.463352750763149 no 1835 0.462345710289884 2640 8407 SGTC_2885 9057732 51.95 µM -0.0952360636301412 0.463104264505223 no 1836 0.462063662760745 2678 6471414 SGTC_3089 9117425 49.47 µM -0.0957631003392719 0.462919867336113 no 1837 0.461854362144627 2631 9401657 SGTC_2702 st077768 96.8 µM -0.0987003129120184 0.461892356001832 no 1838 0.460688110206006 2653 6484119 SGTC_1913 st060213 96.1 µM -0.100622109930851 0.461220199929663 no 1839 0.459925222298322 2648 688959 SGTC_376 3970-0862 59.1 µM -0.102484580675033 0.460568899124574 no 1840 0.459186025621194 2662 3135186 SGTC_2283 7944793 200 µM -0.103603739791495 0.460177583076476 no 1841 0.458741909856778 2636 2970533 SGTC_851 0394-0702 453 µM -0.103763741369433 0.460121641372032 no 1842 0.458678420645901 2590 762646 SGTC_2761 levamisole 97.89 µM -0.10424423064515 0.459953651596291 no 1843 0.458487767087275 2618 26879 An alkaline phosphatase inhibitor. SGTC_2347 9049783 174.81 µM -0.105331752305131 0.459573456195976 no 1844 0.458056284206291 2680 6467988 YPL169C MEX67 SGTC_1017 4239-0030 168 µM -0.107197741404916 0.458921196453029 no 1845 0.457316053602021 2624 1149593 SGTC_35 0133-0054 64.071 µM -0.110162627088787 0.457885043618136 no 1846 0.456140200545014 2632 99677 SGTC_1710 st031758 61.5 µM -0.110775832196797 0.457670779364717 no 1847 0.45589705524599 2752 5394341 SGTC_1053 3366-3204 134 µM -0.111242292684588 0.457507798402517 no 1848 0.455712107511424 2635 3632071 YPR165W RHO1 SGTC_866 0495-0101 262 µM -0.112656356518698 0.457013769283082 no 1849 0.455151501675581 2632 635694 SGTC_1524 corynanthine 62.1 µM -0.112801942295541 0.456962909982024 no 1850 0.455093789222213 2806 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1552 6-methylflavone 10.6 µM -0.112880025479035 0.456935632496896 no 1851 0.455062836231151 2611 689013 SGTC_1363 1636-0063 10.4 µM -0.113857213730526 0.456594279932116 no 1852 0.454675491713984 2610 6072185 SGTC_2769 toremifene 3.73 µM -0.114100077049691 0.456509447587471 no 1853 0.454579230573565 2733 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_781 4335-2806 94.4 µM -0.114776012290516 0.456273353334164 no 1854 0.454311331400764 2779 845254 SGTC_1366 1683-0113 21.9 µM -0.115439576834622 0.456041594998768 no 1855 0.454048355426925 2610 708623 SGTC_2307 7538926 6.34 µM -0.116082208175659 0.455817162104331 no 1856 0.453793694649375 2675 96582 SGTC_2381 9035592 200 µM -0.116360030476416 0.455720139664147 no 1857 0.453683605609394 2645 4749657 SGTC_3041 9091929 49.47 µM -0.118499969266229 0.454972908877923 no 1858 0.452835759723535 2720 25236887 SGTC_3058 9093861 49.47 µM -0.118682884070136 0.454909045444202 no 1859 0.452763298614256 2727 17217477 SGTC_72 0744-0168 198.391 µM -0.119013635935783 0.454793568686934 no 1860 0.452632276325555 2648 677577 SGTC_166 k072-0058 166.424 µM -0.119149270766763 0.454746215045297 no 1861 0.452578548153784 2598 5846229 SGTC_1128 3448-9350 235 µM -0.119966335118071 0.454460970292049 no 1862 0.452254907999911 2724 619386 SGTC_1967 st070177 51.4 µM -0.121575771089655 0.453899170070291 no 1863 0.451617501496349 2742 5729214 SGTC_1408 3909-7976 48.8 µM -0.122151460983937 0.453698238336562 no 1864 0.451389533507236 2644 24152374 SGTC_2401 5128683 200 µM -0.122952468236901 0.453418684325593 no 1865 0.451072368568396 2661 708373 SGTC_1359 1582-0056 520 nM -0.124110476037418 0.453014576857956 no 1866 0.450613901807487 2730 3661189 SGTC_407 eburnamonine 100 µM -0.126174863596608 0.452294292962291 no 1867 0.449796754135166 2619 3195 SGTC_3216 9129716 49.47 µM -0.12823466620046 0.451575765247575 no 1868 0.448981633435043 2675 8056934 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.128317334863407 0.451546930961021 no 1869 0.448948923635732 2742 521171 SGTC_2337 9009472 200 µM -0.129630811685894 0.45108883327069 no 1870 0.448429262361471 2702 5742383 SGTC_1150 3909-7983 10.9 µM -0.131073226605675 0.450585841258378 no 1871 0.447858690243782 2664 23965914 SGTC_1505 k297-0037 20.6 µM -0.131289583024079 0.450510401310127 no 1872 0.447773116002575 2663 4089396 SGTC_2273 7815444 169.05 µM -0.131763942602617 0.450345006136468 no 1873 0.447585503730328 2687 2824616 SGTC_2282 7944268 200 µM -0.13213440159168 0.450215844024923 no 1874 0.447438992963863 2752 2970414 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.132365578044041 0.450135246036767 no 1875 0.447347569906383 2634 3256 An antibiotic and ribosome inhibitor. SGTC_3207 9114163 49.47 µM -0.133035938721399 0.449901541304409 no 1876 0.4470824790571 2815 849233 SGTC_2453 5731132 22.18 µM -0.133137272134234 0.449866215416557 no 1877 0.447042409308869 2744 1362040 SGTC_2873 9040596 71.43 µM -0.13323194424217 0.449833212088233 no 1878 0.447004974094483 2753 6463863 SGTC_1000 4048-0884 8.67 µM -0.133564024579614 0.449717449412172 no 1879 0.446873666729693 2765 13040088 SGTC_3050 9093513 49.47 µM -0.133635045910313 0.449692692044645 no 1880 0.446845585052317 2665 25236664 SGTC_2934 9036370 36.88 µM -0.134477141295403 0.449399160469668 no 1881 0.446512642749071 2744 6462800 SGTC_1677 st019204 53.9 µM -0.134492281627917 0.449393883213957 no 1882 0.446506657005272 2765 3945625 SGTC_3307 9126885 69.2785 µM -0.134819356163167 0.449279881566599 no 1883 0.446377350777604 2648 24824909 SGTC_2750 bromebric acid 70.15 µM -0.135008118164162 0.44921409058088 no 1884 0.446302727866857 2750 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_333 3486-0131 40.1 µM -0.135515641429247 0.449037205679212 no 1885 0.446102099129838 2790 6744690 SGTC_967 1306-0166 352 µM -0.135923954485628 0.448894905435468 no 1886 0.445940699138296 2703 4437607 SGTC_458 nppb 133 µM -0.136460075183036 0.448708073229966 no 1887 0.445728792320353 2730 4549 A chloride channel blocker. SGTC_1522 st012842 45.6 µM -0.137080677247877 0.448491814397424 no 1888 0.445483512799336 2626 3491067 YOR116C RPO31 SGTC_40 0327-0103 19.753 µM -0.137347050079759 0.448398997164094 no 1889 0.445378241102951 2702 409036 SGTC_1406 3909-7906 11.9 µM -0.138407964226124 0.44802935122024 no 1890 0.444959001527775 2690 X1406 SGTC_592 k241-0073 46.5 µM -0.142651928895808 0.446551114561408 no 1891 0.443282541751167 2710 4230158 SGTC_1120 ficusin 1.78878 µM -0.144669055534817 0.445848778073747 no 1892 0.442486086095303 2815 6199 A DNA cross-linker. SGTC_2225 6654152 15.4 µM -0.147427887897014 0.444888465076914 no 1893 0.441397147330804 2661 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1831 st055328 12 µM -0.147699585940547 0.444793907986803 no 1894 0.441289929212206 2745 1103068 SGTC_2380 9035439 200 µM -0.14796399873198 0.444701889345993 no 1895 0.441185590147835 2798 6462575 SGTC_75 0159-0059 199.013 µM -0.148352493218795 0.444566694279617 no 1896 0.44103229501954 2950 5377270 SGTC_2090 5301565 104.445 µM -0.148987625525233 0.444345683792847 no 1897 0.440781698691203 2703 2056344 SGTC_515 4092-1064 102 µM -0.14927162385727 0.444246864923577 no 1898 0.440669652634641 2823 717353 SGTC_2721 ifenprodil 61.44 µM -0.149520039940918 0.444160429945767 no 1899 0.440571648761089 2804 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2363 9053361 176 µM -0.150609028154351 0.443781554020993 no 1900 0.440142069599323 2808 6469797 YMR079W SEC14 SGTC_1081 sertraline 6 µM -0.150918463465137 0.443673906025904 no 1901 0.440020017784327 2773 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2211 7117706 200 µM -0.15174309680862 0.443387048527879 no 1902 0.43969478220084 2692 822771 SGTC_738 1315-0003 72.4 µM -0.152467936649609 0.443134929756136 no 1903 0.439408938796735 2805 6251474 SGTC_3251 9135047 49.47 µM -0.15314660269714 0.442898892336051 no 1904 0.439141332838371 2786 17682963 SGTC_658 3253-0951 102 µM -0.153889739599891 0.442640455448102 no 1905 0.438848337173172 2726 1184878 SGTC_1970 st070122 35.8 µM -0.154382989941605 0.442468933789108 no 1906 0.43865388246266 2831 102928 SGTC_1571 st070080 73.4 µM -0.154553528487171 0.442409633642347 no 1907 0.438586654277008 2814 4315245 SGTC_943 3253-1379 105 µM -0.155091741331387 0.442222493213905 no 1908 0.438374496435296 2807 668464 SGTC_1152 3909-8331 15.9 µM -0.15558753290854 0.442050114369175 no 1909 0.438179076279368 2684 16001939 SGTC_439 amiodarone 34.4 µM -0.157248660972242 0.441472646719842 no 1910 0.437524439693375 2753 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2101 5377231 179.231 µM -0.160725800033717 0.440264272684595 no 1911 0.436154684061652 2811 2844213 SGTC_2724 maprotiline 69.64 µM -0.163477980602498 0.43930822967599 no 1912 0.435071054426512 2706 4011 A tricyclic antidepressant. SGTC_1294 1000-1494 117 µM -0.163761158009694 0.43920988046921 no 1913 0.434959585110133 2721 712797 YDL207W GLE1 SGTC_2804 7954240 19.48 µM -0.16541390773946 0.438635945659244 no 1914 0.434309103835918 2848 828705 SGTC_961 1252-1571 372 µM -0.166804963556102 0.438152986764009 no 1915 0.433761756527426 2833 6813498 SGTC_408 cantharidin 100 µM -0.1672463785298 0.437999751677717 no 1916 0.433588096749135 2751 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_425 3825-7017 13.1 µM -0.168405653959237 0.437597359110224 no 1917 0.433132080206915 2962 3397440 SGTC_1765 st044815 90.4 µM -0.168426321476484 0.437590185855435 no 1918 0.433123951167634 2787 645695 SGTC_1111 tnp00062 510.699 nM -0.169316579457368 0.437281215784908 no 1919 0.432773817867953 2836 676306 SGTC_2849 9019321 12.99 µM -0.169844754700117 0.437097927048311 no 1920 0.432566114534116 2815 16489627 SGTC_1603 st002045 67.8 µM -0.170253384029764 0.43695613270375 no 1921 0.432405435053402 2754 5887985 SGTC_715 0868-0130 184 µM -0.171731637577853 0.43644324661257 no 1922 0.431824256056295 2826 2876258 SGTC_3149 9097855 49.47 µM -0.171738959420209 0.436440706534716 no 1923 0.4318213778222 2849 25236625 YMR079W SEC14 SGTC_593 1203-0218 61.7 µM -0.172120867780414 0.436308219341323 no 1924 0.431671253735261 2839 3666956 SGTC_873 0591-4978 488 µM -0.172336436322098 0.436233439971396 no 1925 0.431586520405455 2926 3305145 SGTC_2055 5235184 200 µM -0.172773465103717 0.436081844435429 no 1926 0.4314147475651 2859 2836034 SGTC_1697 st025554 27.742 µM -0.174020063319268 0.43564947898535 no 1927 0.430924847276377 2692 1269519 SGTC_823 0417-1665 178 µM -0.174699084698616 0.435414002077876 no 1928 0.430658043509885 2806 3429856 SGTC_2290 7904846 200 µM -0.174778965814612 0.435386301717333 no 1929 0.430626658384011 2804 2962154 SGTC_2080 5212524 12.4 µM -0.175582860081423 0.435107553116574 no 1930 0.430310834409355 2714 260183 SGTC_2325 6158266 200 µM -0.175808754268226 0.435029230592954 no 1931 0.430222095926787 2801 3623240 SGTC_496 calpeptin 138 µM -0.177970383517801 0.434279875146237 no 1932 0.42937311746509 2795 73364 A calpain inhibitor. SGTC_144 4161-2749 112.381 µM -0.178706695184137 0.434024677392489 no 1933 0.429084005910289 2715 797501 YMR168C CEP3 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.180692900213463 0.433336417371518 no 1934 0.428304315932982 2873 23847180 SGTC_3132 9126706 49.47 µM -0.180706319947393 0.433331767848707 no 1935 0.428299048929523 2935 850858 SGTC_762 1165-0429 115 µM -0.181660654819171 0.433001144025887 no 1936 0.427924522516014 2872 5967793 SGTC_1019 4262-0212 3.4 µM -0.182082375291729 0.432855056321343 no 1937 0.427759040000484 2786 4677213 SGTC_1800 st050079 29.0735 µM -0.182150963692907 0.432831297559131 no 1938 0.427732127209702 2809 3645560 SGTC_3159 9100096 49.47 µM -0.184210878821159 0.432117864298291 no 1939 0.4269240127294 2663 25236875 SGTC_263 alizarin 107.927 µM -0.185477997235527 0.431679118903448 no 1940 0.426427068251468 2710 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_118 0083-0097 135.343 µM -0.188709370090574 0.430560624347936 no 1941 0.425160303635876 2767 5207356 SGTC_2373 9071805 200 µM -0.190698849102316 0.429872270362161 no 1942 0.424380770214087 2782 10149009 SGTC_3318 9139014 38.6185 µM -0.191623322619207 0.429552477594749 no 1943 0.42401863612443 2733 16643984 SGTC_1269 0831-0796 3.05 µM -0.193678231554314 0.428841811819959 no 1944 0.423213918894488 2856 927758 SGTC_1429 4049-0205 9.46 µM -0.193735380908545 0.428822050682306 no 1945 0.423191543354578 2744 22774478 SGTC_892 0929-0076 29 µM -0.194382543470323 0.428598286889264 no 1946 0.422938178762389 2768 5751038 SGTC_328 k915-0120 63.5 µM -0.19624522128981 0.427954373252101 no 1947 0.422209117335239 2887 6624543 SGTC_3011 9081274 71.4286 µM -0.199310603596669 0.426895112104542 no 1948 0.421009892552155 2787 6625322 SGTC_2061 5245884 80.95 µM -0.199731844164721 0.426749590924451 no 1949 0.420845153751815 2745 573863 SGTC_1417 3966-0327 90.4 µM -0.199956330299249 0.42667204432795 no 1950 0.420757367352892 2796 651118 SGTC_1402 3909-7673 35.9 µM -0.201471416997588 0.426148746325911 no 1951 0.420164988556875 2729 5328014 SGTC_2981 9013952 38.96 µM -0.204602714547525 0.425067635912956 no 1952 0.41894126718429 2826 2996344 SGTC_1345 1488-0192 31.4 µM -0.204757870749678 0.425014081331375 no 1953 0.418880651915593 2859 658348 SGTC_1492 4158-0558 28.5 µM -0.204818701973604 0.424993084863848 no 1954 0.418856887351819 2876 3967268 SGTC_617 3770-0098 35 µM -0.205504920932743 0.424756244705628 no 1955 0.418588826899674 2782 5962639 SGTC_3045 9092950 49.47 µM -0.205675726054256 0.424697297605991 no 1956 0.418522110483552 2832 44120432 SGTC_317 4495-0002 170 µM -0.207659462516731 0.424012807680151 no 1957 0.417747435930063 2812 15991618 SGTC_1344 1488-0097 29.1 µM -0.207761898678735 0.423977468201646 no 1958 0.417707441931866 2874 747966 SGTC_2506 ethyl hematommate 54.16 µM -0.20812375761676 0.423852635287246 no 1959 0.4175661687023 2833 3940691 An allergen. SGTC_1597 7-benzyloxygramine 47.5 µM -0.208831433217452 0.423608525764473 no 1960 0.417289916067501 2763 260807 SGTC_2487 5918373 44.05 µM -0.209096808864687 0.423516993178486 no 1961 0.417186332902046 2766 2876279 SGTC_1091 telmisartan 47.6 µM -0.209168350379632 0.42349231799611 no 1962 0.417158409331392 2879 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1166 k206-0078 225 µM -0.210876344031469 0.422903308019273 no 1963 0.416491881887395 2769 5404595 SGTC_2496 diffractaic acid 79.83 µM -0.210930234115723 0.422884726556906 no 1964 0.416470855717163 3048 94870 An apoptosis inducer which activates caspases. SGTC_1859 st055998 20 µM -0.213211023111818 0.422098461477736 no 1965 0.415581185370558 2883 676301 SGTC_2250 alverine citrate 130 µM -0.214631186806116 0.421609039634072 no 1966 0.415027438489659 2726 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1311 1190-0148 100 µM -0.215126136684999 0.421438496665101 no 1967 0.414834488402426 2908 1961333 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.216195060194306 0.421070232137866 no 1968 0.414417851948048 2864 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_670 4204-0025 119 µM -0.217252644207639 0.420705942232748 no 1969 0.414005730055488 2901 719039 SGTC_3106 9121286 49.47 µM -0.218221378692602 0.420372316543834 no 1970 0.413628314333223 2996 15943471 SGTC_221 trifluoperazine 10.304 µM -0.219620104531505 0.419890705677206 no 1971 0.413083516253682 2807 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_734 2023-0417 80 µM -0.221484968754558 0.419248780195832 no 1972 0.412357419594737 2926 3935732 SGTC_194 1486-1323 56.904 µM -0.221603116837016 0.41920811836157 no 1973 0.41231142796772 2832 5178754 SGTC_2646 retinol 96.75 µM -0.222092320913524 0.419039763114995 no 1974 0.41212100780966 2867 445354 A vitamin A analog and teratogen. SGTC_2395 5646831 180.19 µM -0.223237560372792 0.418645697129177 no 1975 0.411675310249476 2961 6808628 SGTC_1979 st071809 45.3 µM -0.22324565247209 0.418642913004864 no 1976 0.411672161418549 2947 4976333 SGTC_1841 st054148 70 µM -0.224029989080737 0.418373077716033 no 1977 0.411366984160728 2880 675442 SGTC_2759 disulfiram 3.38 µM -0.224060109696548 0.418362716086945 no 1978 0.411355265608779 2785 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_697 0508-1955 564 µM -0.224936079128333 0.41806140342016 no 1979 0.411014500661873 2929 6243113 SGTC_3209 9113616 49.47 µM -0.225641000084222 0.417818962273832 no 1980 0.410740324819421 2989 16649353 SGTC_3072 9116419 49.47 µM -0.226085233655989 0.417666194518 no 1981 0.410567564556175 2889 17170162 SGTC_775 4577-0580 57.3 µM -0.226587980036634 0.417493319744905 no 1982 0.410372069878181 3002 2006902 SGTC_720 r052-1644 49.9 µM -0.226769489836153 0.417430909555934 no 1983 0.410301494630392 2922 1422863 YOR257W CDC31 SGTC_2936 9038235 15.59 µM -0.227515383605706 0.417174463872675 no 1984 0.410011504238353 2790 4749415 SGTC_106 0092-0003 11.579 µM -0.231857344460803 0.415682357461628 no 1985 0.408324407971603 2899 1072148 SGTC_2685 mycophenolic acid 18.85 µM -0.231882340584526 0.41567377108883 no 1986 0.408314700455741 2866 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2789 5281112 71.43 µM -0.232113925613473 0.415594221653547 no 1987 0.408224764573261 2870 765948 SGTC_3292 9120825 59.784 µM -0.232128957777495 0.41558905822616 no 1988 0.408218927010008 2924 24824900 SGTC_538 2922-0838 53.3 µM -0.232240858629918 0.415550621641881 no 1989 0.408175472276664 2988 777039 SGTC_116 0155-0182 31.788 µM -0.232478877909626 0.415468867596629 no 1990 0.408083045420463 2831 771486 SGTC_1679 SEC14.276 6.7 µM -0.233111469764659 0.41525160491261 no 1991 0.40783742432407 2969 1005053 YMR079W SEC14 SGTC_2905 7799065 20.05 µM -0.236118580891723 0.414219172739422 no 1992 0.406670328028777 2997 1296806 SGTC_1282 0886-0010 32.4 µM -0.236616010599481 0.414048446999058 no 1993 0.40647734910813 2973 2836211 YNL267W PIK1 SGTC_695 3505-6186 243 µM -0.23770534813038 0.41367462590872 no 1994 0.406054817672938 2949 1819379 SGTC_1042 0350-0096 82 µM -0.238564449445087 0.413379868681104 no 1995 0.40572166722527 2796 3122515 SGTC_2162 5663267 200 µM -0.239313497475809 0.413122910505925 no 1996 0.405431249988586 2963 6456493 SGTC_416 estradiol valerate 100 µM -0.239965837842985 0.412899157851686 no 1997 0.405178370176153 2879 13791 A steroid. SGTC_2662 daunorubicin 22.37 µM -0.240321595948432 0.4127771447898 no 1998 0.405040477181921 2813 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.240409648465483 0.412746947039148 no 1999 0.405006349560408 3017 6728940 SGTC_346 4513-0042 7.16 µM -0.241534726312067 0.412361145314327 no 2000 0.40457035266235 2832 2827372 SGTC_2034 5197015 53.07 µM -0.24291882922888 0.411886637192002 no 2001 0.404034139388452 2986 780676 SGTC_1445 4239-0156 97.7 µM -0.243132796144631 0.411813294992445 no 2002 0.403951262843029 3016 4008346 SGTC_2678 equilin 100 µM -0.243678052239113 0.411626409558436 no 2003 0.403740086414702 2928 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2017 5132927 60.65 µM -0.244007988454322 0.411513334314192 no 2004 0.403612316500413 2846 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.244266291514934 0.411424814205622 no 2005 0.403512294162347 2933 6708739 YPR165W RHO1 SGTC_430 0958-0115 16.4 µM -0.24451333300118 0.411340157641405 no 2006 0.403416638532089 2870 6833180 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.24452192140977 0.411337214626297 no 2007 0.403413313163614 2812 16486 A toxic proline analog. SGTC_457 grayanotoxin iii 135 µM -0.246260920103938 0.410741409857464 no 2008 0.402740129875721 2875 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1583 clindamycin 39.6 µM -0.246967338570384 0.410499439944642 no 2009 0.402466750639893 2830 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1372 2752-0194 270 µM -0.248048530729007 0.410129164582346 no 2010 0.402048428881174 2815 823334 SGTC_2 0422-0095 29 µM -0.248846565574291 0.409855913339197 no 2011 0.401739734845026 2855 6790840 SGTC_2492 derrusnin 100 µM -0.250682577425631 0.409227419828558 no 2012 0.401029765927709 2785 1715307 Part of coumarin class of compounds. SGTC_2781 5567276 71.43 µM -0.251849248665499 0.408828172425179 no 2013 0.400578794487137 3015 2853274 SGTC_808 0711-0032 135 µM -0.25187889492844 0.408818028386766 no 2014 0.400567336583225 2858 4252555 SGTC_2944 9067346 25.62 µM -0.252799188668466 0.408503162612789 no 2015 0.400211697345641 3019 6473075 SGTC_1367 1812-0510 76.9 µM -0.254280791940621 0.407996376694395 no 2016 0.399639319014805 2897 1142582 YDR527W RBA50 SGTC_3344 9148862 3.898 µM -0.254894860348663 0.407786378193879 no 2017 0.399402153017345 3016 4905352 SGTC_2902 5787006 60.46 µM -0.255001108482763 0.407750046249789 no 2018 0.39936112154152 2853 591003 SGTC_1164 k060-0068 93.7 µM -0.256321509803989 0.407298596402535 no 2019 0.398851294748244 2867 5963676 SGTC_366 0181-0206 4.31 µM -0.256762753294974 0.407147761118141 no 2020 0.398680962422961 3023 274874 SGTC_2626 ethyl orsellinate 100 µM -0.257754629688614 0.406808747017804 no 2021 0.398298140890583 2847 75653 A natural product. SGTC_2765 myclobutanil 7.74 µM -0.257859799596694 0.406772805013876 no 2022 0.398257555571555 2984 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2664 lyso-paf C-16 73.48 µM -0.258503345873409 0.406552889039002 no 2023 0.398009233512978 2868 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1114 scopoletin 1.73284 µM -0.258857001854894 0.406432048423736 no 2024 0.397872787587926 2992 5280460 A coumarin with genotoxic properties. SGTC_835 0312-0010 67.2 µM -0.259184445743517 0.406320172155557 no 2025 0.397746465827904 2842 1626196 SGTC_2948 9070189 9.45 µM -0.260733856351823 0.405790895917944 no 2026 0.397148877633677 3020 6473636 YDL196W YDL196W SGTC_2923 7992654 58.14 µM -0.260833782846494 0.405756767083528 no 2027 0.397110345511775 2901 2985126 SGTC_2352 9027995 87.8 µM -0.262165482605732 0.405302007637422 no 2028 0.396596931896085 2927 2997347 SGTC_977 1348-1378 135 µM -0.262207053013072 0.405287813897562 no 2029 0.396580908030671 2856 X977 SGTC_864 0469-0573 172 µM -0.262735539138003 0.405107379222116 no 2030 0.396377211270823 2864 689425 SGTC_2823 7987624 58.44 µM -0.265887203609775 0.404031764296113 no 2031 0.395163040259964 3099 2239440 SGTC_743 1275-0778 158 µM -0.266776516071119 0.403728386372669 no 2032 0.394820618307664 2984 2849257 YMR203W TOM40 SGTC_497 capsazepine 133 µM -0.268725521012503 0.403063710261829 no 2033 0.394070455506834 2885 2733484 A calcium channel blocker. SGTC_875 0709-0210 25.7 µM -0.270805332590129 0.402354733537939 no 2034 0.39327037913505 2968 6251364 SGTC_2880 9042983 58.44 µM -0.271484650084259 0.402123233793117 no 2035 0.393009152006074 3029 6464714 SGTC_3187 9109394 49.47 µM -0.273271481999149 0.401514476245426 no 2036 0.392322267689348 2934 17098090 SGTC_1251 0490-5699 265 µM -0.274318611475572 0.401157839604316 no 2037 0.391919891506953 3055 3883818 SGTC_649 1123-0311 367 µM -0.277355151799451 0.400124105981802 no 2038 0.390753707442518 2992 693629 YIL048W NEO1 SGTC_2546 rhodinyl acetate 100 µM -0.277979160538923 0.399911760218841 no 2039 0.390514178009992 3056 6708682 SGTC_1214 0358-0031 63.7 µM -0.279162074130757 0.399509304355552 no 2040 0.390060223752589 3152 4301366 SGTC_1609 st001574 46.4 µM -0.281019528455459 0.398877568968606 no 2041 0.389347710798995 2893 3960012 SGTC_1277 0873-0036 22 µM -0.281114221337654 0.398845370226231 no 2042 0.389311396883742 2967 5965735 SGTC_2536 dehydroabietamide 32.04 µM -0.282821092594264 0.39826509523725 no 2043 0.388656992310073 3058 3983547 SGTC_1238 0333-0287 48.8 µM -0.282944401202466 0.398223183430083 no 2044 0.388609728713779 2913 7226 SGTC_655 k060-0012 42 µM -0.284149693037836 0.397813574346572 no 2045 0.388147833086399 2907 5994525 SGTC_2963 9082507 9 µM -0.285193621203081 0.397458894448174 no 2046 0.387747903535948 3075 16459611 SGTC_292 k038-0015 474 µM -0.285459069813262 0.397368720439416 no 2047 0.387646228971738 3030 46368540 SGTC_1701 st028638 40.4 µM -0.286192912556672 0.397119459530036 no 2048 0.387365185894547 3025 3490878 SGTC_2174 5790901 200 µM -0.286210160834335 0.39711360139378 no 2049 0.387358580952922 2992 786020 SGTC_2320 7373003 200 µM -0.289146946422457 0.396116502732745 no 2050 0.386234464549456 2980 5415828 SGTC_1383 3049-0032 20.7 µM -0.290244118945333 0.395744164193129 no 2051 0.385814743053769 3066 712864 SGTC_1568 digitonin 820 nM -0.290765569548889 0.395567237057149 no 2052 0.385615309827641 3080 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_3257 9139206 32.98 µM -0.294574897716418 0.394275394740687 no 2053 0.384159320207475 3042 4910041 SGTC_1837 st055472 66.5 µM -0.29472571453824 0.3942242726548 no 2054 0.384101708945766 3098 676091 SGTC_2323 6148992 148.28 µM -0.295497233595366 0.393962780856038 no 2055 0.383807032657482 2959 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_3014 9081533 49.47 µM -0.295895775222941 0.39382772142111 no 2056 0.383654838782282 3079 21367265 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.297387816538557 0.39332220580636 no 2057 0.383085222083425 2979 17037758 SGTC_189 3970-0742 2.116 µM -0.297623112514389 0.393242502025656 no 2058 0.382995416162539 2953 2891807 SGTC_91 0417-1751 58.384 µM -0.300878049685761 0.392140390289165 no 2059 0.381753744504534 2920 6795624 SGTC_530 4358-1714 28 µM -0.301360996167036 0.391976939549661 no 2060 0.381569616569129 3026 1564641 SGTC_2104 5389443 200 µM -0.301651624119684 0.391878587206903 no 2061 0.381458824812598 3107 2244536 SGTC_1207 2099-0101 141 µM -0.302938217062779 0.391443270213451 no 2062 0.380968472975343 3050 5837381 SGTC_169 k015-0017 16.025 µM -0.304925820417995 0.390771034645697 no 2063 0.380211324910022 3173 1840002 SGTC_3017 9080681 49.47 µM -0.305857963315309 0.39045588300675 no 2064 0.379856396731001 3008 16451914 SGTC_1529 apigenin 74 µM -0.310438968564336 0.388908123501785 no 2065 0.37811358212216 3188 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_411 enrofloxacin 100 µM -0.311246195459589 0.388635571960452 no 2066 0.377806733458269 3118 71188 A bacterial gyrase inhibitor. SGTC_2526 patulin 37.61 µM -0.314464108865275 0.387549623877193 no 2067 0.376584285901251 3110 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1900 st060200 72.8 µM -0.314546248193381 0.387521915818983 no 2068 0.376553098268143 2930 688945 SGTC_235 0330-0087 5 mM -0.315010037135003 0.387365476656262 no 2069 0.376377016513761 2988 46494818 YHR062C RPP1 SGTC_608 k048-0125 159 µM -0.31622695692947 0.386955088346465 no 2070 0.375915124059998 3083 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2736 butenafine 14.65 µM -0.316538847685684 0.386849928096922 no 2071 0.375796771806249 2979 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_609 0986-0026 86.3 µM -0.317597577957474 0.386493017862621 no 2072 0.375395105800709 2969 2848610 SGTC_3108 9121785 49.47 µM -0.318126371580058 0.386314791339023 no 2073 0.375194540162233 2885 17140271 SGTC_2549 cedrol 20.94 µM -0.318898518460249 0.386054587237885 no 2074 0.374901733906549 3129 6708665 A sedative which affects the nervous system. SGTC_744 1594-0068 283 µM -0.319061403452745 0.385999703519702 no 2075 0.374839975398862 2990 668392 SGTC_1806 st050005 60.3 µM -0.32042007649813 0.385541990793375 no 2076 0.374324954166427 2975 5194765 SGTC_3284 9108171 64.8615 µM -0.320993795165008 0.385348763016976 no 2077 0.374107546522675 3058 8687505 SGTC_2360 9040895 200 µM -0.321433091024636 0.385200827919649 no 2078 0.373941104747838 3018 4914414 SGTC_2126 5251174 33.877 µM -0.321863294020315 0.385055971079613 no 2079 0.373778130881251 3143 790722 SGTC_2480 5767542 37.17 µM -0.324329762826098 0.384225778249649 no 2080 0.372844194492288 3002 2867358 SGTC_2610 ononetin 44.17 µM -0.325217266036246 0.383927181744883 no 2081 0.372508320973132 3030 259632 SGTC_788 1182-0090 188 µM -0.32877360327741 0.382731360716793 no 2082 0.37116340822537 3172 5715185 SGTC_1130 3454-2858 15.9 µM -0.329352120637265 0.382536939167281 no 2083 0.370944776471494 3057 715628 YIL048W NEO1 SGTC_1912 st060209 90.8 µM -0.329457134084675 0.382501650612567 no 2084 0.370905094531403 3050 688787 SGTC_1322 1348-1070 12 µM -0.329594283986908 0.382455564443058 no 2085 0.370853271100855 3114 6758089 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.330905699242038 0.382014976713104 no 2086 0.370357858449226 3049 75037 A free radical scavenger. SGTC_819 1013-0258 27.7 µM -0.330934300592646 0.382005369401759 no 2087 0.370347056124273 3000 5753198 SGTC_3027 9089541 49.47 µM -0.33334850738607 0.381194689877356 no 2088 0.369435613763247 3083 9943819 SGTC_2514 salinomycin 42.74 µM -0.334199092958067 0.380909191111898 no 2089 0.369114664200401 3169 23682228 A polyether potassium ionophore. SGTC_559 1550-0661 158 µM -0.337504374714056 0.37980039107353 no 2090 0.367868357434681 3070 5830875 SGTC_1301 naphtanilide LB 4.81 µM -0.337696481954957 0.379735976463036 no 2091 0.367795963088618 3118 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_63 0099-0242 26.702 µM -0.339365908416448 0.379176349305176 no 2092 0.3671670487322 3143 3898502 YLR359W ADE13 SGTC_1296 1068-0102 11.9 µM -0.341645474178025 0.378412599486529 no 2093 0.36630885535037 3098 767053 SGTC_340 k038-0059 454 µM -0.342645195826777 0.37807780052198 no 2094 0.365932698352457 3034 23733424 SGTC_1280 0880-0253 10.1 µM -0.343840518704162 0.377677616406196 no 2095 0.365483113232031 3013 6836607 SGTC_3026 9090633 49.47 µM -0.344039074915001 0.377611154147026 no 2096 0.365408450100873 2997 25236842 SGTC_1458 k015-0034 6.33 µM -0.344055407853293 0.377605687221808 no 2097 0.365402308649847 3058 3598957 SGTC_2215 7188065 200 µM -0.344215610589255 0.377552065813956 no 2098 0.365342071639429 3126 940217 SGTC_1304 1165-0502 251 µM -0.346194956532027 0.376889754559819 no 2099 0.36459810237979 3024 767425 SGTC_2657 nystatin 74.44 µM -0.346702144680269 0.376720101945598 no 2100 0.364407549413521 3070 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_192 3455-0609 60.9 µM -0.347290624561169 0.376523287373555 no 2101 0.364186496754851 3146 3769639 SGTC_2665 lovastatin 100 µM -0.351581658661456 0.37508914265409 no 2102 0.362576011172212 3058 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2177 5811945 192 µM -0.353460836995062 0.374461627720909 no 2103 0.361871491942472 3167 5343475 SGTC_3068 9116768 49.47 µM -0.355055132824459 0.373929504264846 no 2104 0.361274144188836 3138 41904888 SGTC_2047 4141938 200 µM -0.35557560296041 0.373755840421393 no 2105 0.361079208546981 3057 3807862 SGTC_179 1273-0063 6.77 µM -0.359239333677153 0.372534100425048 no 2106 0.359708026906326 3023 3108139 SGTC_1530 rhein 70.4 µM -0.359469698706295 0.37245732356281 no 2107 0.359621870978847 3021 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2718 lomofungin 53.02 µM -0.360597818242515 0.372081413175671 no 2108 0.359200060266152 3183 5351222 A RNA synthesis inhibitor. SGTC_1151 3909-8316 15.3 µM -0.362249399562909 0.371531295516343 no 2109 0.358582833590869 3150 800431 SGTC_975 1335-0046 28.5 µM -0.362788671712541 0.371351728572235 no 2110 0.358381377430767 3048 16486740 SGTC_1604 st002052 72.4 µM -0.363787262602738 0.371019291534586 no 2111 0.358008437436793 3169 6254834 YHR062C RPP1 SGTC_676 falcarinol 140 µM -0.365390852711959 0.370485647982209 no 2112 0.357409834203816 3244 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_3340 9146634 11.102 µM -0.366836803207258 0.370004677370682 no 2113 0.356870376765632 3141 4907387 SGTC_2140 5586273 200 µM -0.367608114005311 0.369748197147609 no 2114 0.356582731880682 3106 854421 SGTC_1377 2944-0135 198 µM -0.371155383827967 0.368569388303763 no 2115 0.35526090098281 3108 1894137 SGTC_2682 pyrogallin 40.03 µM -0.373580345308097 0.367764249094378 no 2116 0.354358279524288 3091 822798 An ATP competetive kinase inhibitor. SGTC_364 0083-0097 67.7 µM -0.374141548790802 0.367578000127138 no 2117 0.354149504129988 3184 5207356 SGTC_2451 5856223 45.7 µM -0.374199730110909 0.367558693027852 no 2118 0.354127862387426 3084 2179896 SGTC_1339 1486-1321 22.7 µM -0.374532353524474 0.36744832050217 no 2119 0.354004145293794 3079 3469382 SGTC_229 benomyl 22.8748 µM -0.376719638265511 0.366722799429928 no 2120 0.353190983530598 3150 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_671 0560-0003 407 µM -0.377416526099814 0.366491741983991 no 2121 0.352932043691938 3084 3238678 SGTC_2583 asiatic acid 100 µM -0.377989434277553 0.366301826987429 no 2122 0.352719221478166 3237 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1011 4112-3381 17.4 µM -0.379053931485712 0.365949040679686 no 2123 0.35232390764816 3234 2877139 SGTC_2973 9094665 17.96 µM -0.3790921432582 0.365936378974937 no 2124 0.352309720210072 3262 25237061 YIL048W NEO1 SGTC_1732 st034308 51.822 µM -0.37967030452441 0.365744819525256 no 2125 0.352095082994091 2966 830119 SGTC_891 0929-0073 133 µM -0.379765717855968 0.365713209891869 no 2126 0.352059666172447 3190 5603632 SGTC_1434 4073-0095 163 µM -0.37995215940912 0.365651446006772 no 2127 0.351990463958126 3157 24133745 SGTC_83 0170-0301 39.027 µM -0.380163858953581 0.365581318940959 no 2128 0.351911892583205 3107 3089716 SGTC_1827 berberine 7.24 µM -0.381031944504124 0.365293806079879 no 2129 0.351589772524594 3070 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_207 4185-0010 4.486 µM -0.382352075285219 0.364856719435301 no 2130 0.351100116527988 3161 3761753 SGTC_2011 4012611 177 µM -0.382764144416438 0.364720321976601 no 2131 0.350947324571197 3050 2049887 SGTC_2341 7987486 176.74 µM -0.38405828611857 0.364292064377619 no 2132 0.350467623902069 3233 1258686 SGTC_1027 k015-0025 8.67 µM -0.384416186145335 0.364173657912749 no 2133 0.350335002823592 3037 3598955 SGTC_1333 1482-0047 286 µM -0.386489355789202 0.363488032664998 no 2134 0.349567142121633 3213 3811116 SGTC_2351 9026858 72.31 µM -0.386776238287746 0.363393191115232 no 2135 0.349460934940742 3024 1409300 SGTC_3233 9132340 49.47 µM -0.38752273993335 0.363146441620419 no 2136 0.349184626741951 3085 17682950 SGTC_1399 3562-5772 25 µM -0.388258263567558 0.362903376350813 no 2137 0.34891246008174 3038 23847490 SGTC_1361 1608-0041 5.61 µM -0.388886349826389 0.362695859145775 no 2138 0.348680110107205 3083 X1361 SGTC_561 1550-0330 72.9 µM -0.389825426900898 0.362385667039268 no 2139 0.348332820168587 3100 6812934 SGTC_1469 k284-2957 126 µM -0.390800391606069 0.362063716245843 no 2140 0.347972392743107 3138 23884841 SGTC_1646 st011709 75.6 µM -0.391494305420752 0.361834632906022 no 2141 0.347715948544376 3197 5757843 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.393025807782442 0.36132920984517 no 2142 0.347150210090121 3170 229346 A bile salt which induces apoptosis. SGTC_770 0389-1121 67.2 µM -0.393118070511451 0.361298769218842 no 2143 0.347116139009492 3271 6753108 SGTC_964 1287-0107 19.4 µM -0.393714634329723 0.361101963637882 no 2144 0.34689586782043 3253 51516812 YPR165W RHO1 SGTC_1224 0823-0416 294 µM -0.395680024247819 0.360453844524614 no 2145 0.346170546848877 3233 3598164 SGTC_1579 chlormadinone acetate 49.4 µM -0.398691366781659 0.359461583501957 no 2146 0.345060314947067 3220 45114258 A steroidal progestin. SGTC_809 3998-0021 90 µM -0.40005801408749 0.359011574443997 no 2147 0.344556893781439 3245 715485 SGTC_269 exalamide 29 µM -0.401549676831078 0.358520623590432 no 2148 0.344007735757466 3110 3316 A derivative of salicylamide. SGTC_280 3448-3607 3.04 µM -0.402563916262065 0.358186940474734 no 2149 0.343634529633362 3219 626179 SGTC_103 0844-0104 51.839 µM -0.40428620339022 0.357620559002925 no 2150 0.343001134857662 3219 5375804 SGTC_1929 genistein trimethyl ether 50.5 µM -0.405104775718529 0.357351477793536 no 2151 0.342700248096974 3296 136420 SGTC_1404 3909-7820 48.3 µM -0.405327964644127 0.357278123396487 no 2152 0.342618226718653 3221 23741373 SGTC_2982 9019404 25.97 µM -0.405624197200941 0.357180770257321 no 2153 0.342509373446494 3102 22333232 SGTC_180 1486-1293 102.781 µM -0.406270124387327 0.356968526578327 no 2154 0.3422720671525 3288 4140536 SGTC_1980 st071811 45.7 µM -0.407147316056967 0.356680363130252 no 2155 0.34194989663319 3264 4974850 SGTC_3214 9129694 49.47 µM -0.407353090576666 0.356612776632743 no 2156 0.341874337459556 3263 17158655 SGTC_1158 4092-0494 91.8 µM -0.410865432520015 0.355459846193943 no 2157 0.340585605342351 3259 1148199 SGTC_2102 5377816 72.7585 µM -0.412486650841407 0.354928124416347 no 2158 0.33999138155784 3294 1379702 SGTC_1243 0416-0003 5.65 µM -0.412812605286027 0.354821253033213 no 2159 0.339871957671204 3133 2141977 SGTC_3282 9108498 15.4605 µM -0.413503108600388 0.354594893971941 no 2160 0.339619022677022 3203 16459645 SGTC_594 1487-1584 10.8 µM -0.414253899259558 0.354348829923589 no 2161 0.339344086055808 3136 5013332 SGTC_227 fluconazole 33.516 µM -0.41581224110562 0.35383829326346 no 2162 0.338773700369805 3180 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_951 1171-0579 82.7 µM -0.415983217345035 0.353782294805841 no 2163 0.33871114196475 3154 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2142 5622915 118.518 µM -0.417636960486093 0.35324082119729 no 2164 0.338106284632693 3182 5322196 SGTC_514 4466-0038 2.65 nM -0.418533344506964 0.352947448447444 no 2165 0.337778606193998 3135 5722064 SGTC_3076 9116187 49.47 µM -0.419375573631787 0.352671879398678 no 2166 0.337470836388127 3229 27241210 SGTC_1323 1348-1351 11.2 µM -0.419885085410385 0.352505209689792 no 2167 0.337284701871219 3148 6989654 SGTC_1647 st011722 22.4 µM -0.420033657691222 0.352456614576021 no 2168 0.337230433036896 3259 2854783 SGTC_1275 0867-0008 21.1 µM -0.420774729778196 0.352214260235436 no 2169 0.336959793041129 3093 3422836 SGTC_2686 alizarin 95.37 µM -0.421041175843058 0.352127138487026 no 2170 0.336862507385724 3171 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_299 1273-0059 1.44 µM -0.421728227406577 0.35190252420955 no 2171 0.336611699246141 3239 2848077 SGTC_2067 5224629 34.075 µM -0.42294394928013 0.351505201086364 no 2172 0.336168078135193 3288 2835000 SGTC_438 sphingosine 6.67 µM -0.423698273015185 0.351258753950548 no 2173 0.33589293740898 3094 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1871 st057448 67.3 µM -0.425834872050879 0.350561039627528 no 2174 0.335114087311043 3349 691747 SGTC_600 1495-0418 41.6 µM -0.426689643042753 0.350282051961609 no 2175 0.334802697582815 3160 5377768 SGTC_3330 9141424 71.43 µM -0.428350666945192 0.34974014346587 no 2176 0.334197917960348 3264 27261020 SGTC_184 1494-0393 24.714 µM -0.428417546743877 0.34971833035484 no 2177 0.334173575991984 3105 3090647 SGTC_1285 0929-0069 65.5 µM -0.430915186806092 0.348904070925628 no 2178 0.333265020241472 3194 1206237 SGTC_26 0302-0163 425.158 µM -0.432349517737584 0.348436776572892 no 2179 0.332743701353836 3209 3100915 SGTC_153 4077-0274 519.67 µM -0.432582518386594 0.348360888384998 no 2180 0.332659045921925 3433 3121976 SGTC_3339 9145883 14.936 µM -0.433076836796657 0.348199909242619 no 2181 0.332479474942566 3258 2030670 SGTC_507 nimesulide 162 µM -0.433563627650058 0.348041408239215 no 2182 0.33230267606198 3346 4495 A COX2 inhibitor. SGTC_566 0958-0068 16.5 µM -0.43465638839634 0.347685697781842 no 2183 0.331905929281461 3294 6815365 SGTC_232 clozapine 119 µM -0.43507394715901 0.347549811351401 no 2184 0.331754376662105 3212 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2231 micatex 6.853 µM -0.435164652308634 0.347520295702209 no 2185 0.331721458939426 3234 20737 An antifungal of unknown mechanism. SGTC_2229 7354935 190 µM -0.435395242171383 0.347445265431443 no 2186 0.331637781634298 3236 318112 SGTC_2489 cantharidin 73.42 µM -0.437369999900107 0.346802955738182 no 2187 0.33092151861844 3236 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2030 5175110 200 µM -0.437777386504152 0.346670503865566 no 2188 0.330773832571761 3289 2831986 SGTC_3269 9137823 49.47 µM -0.439550101848072 0.346094366848901 no 2189 0.330131493596314 3145 17682936 SGTC_570 0987-0065 62.6 µM -0.439824496901243 0.3460052195446 no 2190 0.330032111908295 3176 3104428 SGTC_2649 anisomycin 9.56 µM -0.440232196870564 0.345872779007616 no 2191 0.329884471370206 3241 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3007 9078383 71.4286 µM -0.440303176107738 0.345849723468034 no 2192 0.329858770340722 3182 6496995 SGTC_2053 5265679 138 µM -0.441995106290843 0.345300318554629 no 2193 0.329246373585862 3153 764595 SGTC_266 formosanin C 406 nM -0.443224299578587 0.344901378200797 no 2194 0.328801752195798 3255 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1137 ixabepilone 100 µM -0.443313853479488 0.344872319800093 no 2195 0.3287693683919 3233 154225 A novel microtubule stabilizer. SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.443360020163071 0.344857340017317 no 2196 0.328752674447375 3321 688798 SGTC_2296 7971656 126.45 µM -0.444640172868456 0.344442063618149 no 2197 0.328289905442515 3249 666570 SGTC_2156 5649887 115 µM -0.447700803177115 0.343449967999961 no 2198 0.327184570969183 3284 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_293 4049-0273 38.5 µM -0.44821111491451 0.343284656366797 no 2199 0.32700042090779 3209 1380311 SGTC_2276 7947513 42.08 µM -0.44859128297211 0.343161523280714 no 2200 0.326863261603385 3234 2105100 SGTC_1562 morin hydrate 59.1 µM -0.448884727402931 0.343066490599051 no 2201 0.326757406961101 3339 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_3059 1327-0034 3 µM -0.449920280475646 0.342731203608894 no 2202 0.326383961841385 3181 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_712 r015-0009 80.6 µM -0.449962744678671 0.34271745737064 no 2203 0.326368651948341 3285 6813872 YLR060W FRS1 SGTC_1498 4478-3555 97.6 µM -0.451144372608862 0.3423350319713 no 2204 0.325942749411061 3263 3437919 SGTC_3299 9121982 43.1275 µM -0.451686552045506 0.3421596135526 no 2205 0.325747403769995 3205 17594604 YPL160W CDC60 SGTC_51 1013-0126 23.419 µM -0.45234174447333 0.341947676006723 no 2206 0.325511403716222 3437 1627850 SGTC_2269 7935389 174.42 µM -0.452623768882081 0.341856463841807 no 2207 0.325409840160765 3252 97605 SGTC_987 1497-1013 404 µM -0.453377911891923 0.341612604716813 no 2208 0.325138319404845 3302 1676435 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.453752712500565 0.341491434049317 no 2209 0.325003411158561 3230 6312947 SGTC_2697 mebhydrolin 72.4 µM -0.45411724563054 0.341373598462795 no 2210 0.324872220664685 3356 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_838 0109-0203 71.4 µM -0.455613718642992 0.340890024665824 no 2211 0.324333888173447 3221 759422 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.455690842650719 0.340865109707087 no 2212 0.324306153965851 3327 5377381 SGTC_633 0437-0093 97.7 µM -0.460926653494979 0.339175305741413 no 2213 0.322425614225451 3230 2831118 SGTC_2837 9008476 45.46 µM -0.461592811243653 0.338960541105396 no 2214 0.322186675370004 3348 2992805 SGTC_2771 fluoxetine 41.05 µM -0.46209703261706 0.338798018422684 no 2215 0.322005869033009 3348 3386 A selective serotonin reuptake inhibitor. SGTC_3044 9093193 49.47 µM -0.463279050049733 0.338417143422127 no 2216 0.321582180219421 3290 25236277 SGTC_804 1595-0054 20.9 µM -0.464388170567668 0.338059907852158 no 2217 0.321184831901312 3212 761523 Stimulates phospholipase C. SGTC_2159 5658611 73.75 µM -0.465591396294747 0.337672526874409 no 2218 0.320754001287548 3338 793844 SGTC_140 0062-0056 502.533 µM -0.465699002889701 0.337637891080781 no 2219 0.320715483094449 3182 3758964 SGTC_3032 9089427 49.47 µM -0.467118404610313 0.337181150999248 no 2220 0.320207583591105 3294 17173707 SGTC_2109 5483026 200 µM -0.46715099696218 0.337170666132381 no 2221 0.320195925135638 3253 759335 SGTC_2066 5222451 176 µM -0.469178266056712 0.336518748312636 no 2222 0.319471109617524 3231 2281147 SGTC_1139 k015-0024 46.9 µM -0.473347026979736 0.335179726498767 no 2223 0.317982808152435 3331 2766652 SGTC_2089 5281248 129.67 µM -0.473423923233948 0.335155046727339 no 2224 0.317955382693833 3283 2737878 SGTC_2445 5742597 35.57 µM -0.473671459189961 0.335075605157045 no 2225 0.317867104457317 3195 1774255 SGTC_2533 agelasine 13.65 µM -0.475188027084331 0.334589055073917 no 2226 0.317326480094808 3432 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_923 1900-2434 73.3 µM -0.477236267876322 0.333932372820128 no 2227 0.316596943974597 3270 5910570 SGTC_2794 7785382 27.27 µM -0.477843451607318 0.333737802462186 no 2228 0.316380815995433 3341 2205081 SGTC_2308 7584454 197.62 µM -0.479089802182512 0.33333855294198 no 2229 0.315937372103994 3424 893577 SGTC_2642 cholecalciferol 100 µM -0.479580770484878 0.333181330480926 no 2230 0.315762761239049 3319 9821465 A vitamin D precursor, similar to steriods. SGTC_1854 st056233 32.9 µM -0.480016260495635 0.333041898326247 no 2231 0.315607915403656 3323 5393174 SGTC_2644 guaiazulene 100 µM -0.480141182475485 0.33300190593659 no 2232 0.315563503254657 3321 3515 A coloring agent. SGTC_2235 salicylic acid 500 µM -0.48138794907736 0.332602871540594 no 2233 0.315120399968881 3324 338 A COX inhibitor and kinase inhibitor. SGTC_1686 st019653 115.5 µM -0.482347522136952 0.332295884075735 no 2234 0.314779546854123 3354 97252 SGTC_2127 5253358 187.912 µM -0.48267674960531 0.332190583238506 no 2235 0.314662637207222 3193 20612 SGTC_685 1278-0033 54.9 µM -0.48312437655365 0.332047434503317 no 2236 0.314503713355993 3371 3590572 SGTC_2563 tomatine 8.54 µM -0.483687922816189 0.331867250234617 no 2237 0.31430368280046 3431 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1847 st056231 15 µM -0.484473817933423 0.33161603865124 no 2238 0.314024820629893 3241 5393180 SGTC_2372 9071633 200 µM -0.485353104353728 0.331335064258436 no 2239 0.313712945899427 3371 21321366 SGTC_1231 0242-0792 125 µM -0.487186379163881 0.33074954998389 no 2240 0.313063128506603 3233 3707635 SGTC_2959 9079155 11 µM -0.48726117613418 0.330725669984324 no 2241 0.313036628490464 3381 16189457 SGTC_1199 1638-0010 4.46 µM -0.48789884276243 0.330522113799478 no 2242 0.312810747122351 3233 3111136 SGTC_167 3672-0051 66.205 µM -0.489633064732741 0.329968768475806 no 2243 0.312196787323172 3247 3237971 SGTC_100 0086-0128 49.5915 µM -0.490179306292439 0.32979455388255 no 2244 0.312003511420232 3296 93297 SGTC_29 0299-0004 12.984 µM -0.492273486664815 0.329126992493371 no 2245 0.311263010284611 3282 16871 A napthoquinone isolated from Swertia calycina. SGTC_2303 7774051 200 µM -0.49298371948007 0.32890071528466 no 2246 0.31101204545564 3405 2953184 SGTC_2239 6685329 187.64 µM -0.493223162263077 0.328824443940964 no 2247 0.310927456775789 3357 805680 SGTC_3055 9094636 49.47 µM -0.493474368054222 0.328744433308145 no 2248 0.310838723279744 3431 25236176 SGTC_1695 st026914 34.495 µM -0.495167421969071 0.328205389801517 no 2249 0.310240972428573 3266 3289191 SGTC_3253 9135987 49.47 µM -0.495500023081236 0.328099536473568 no 2250 0.310123602864312 3354 4182430 SGTC_24 0417-1663 219 µM -0.496043597464766 0.327926568701824 no 2251 0.309931825877291 3355 4329390 SGTC_903 1134-0042 114 µM -0.496351747118236 0.327828530506974 no 2252 0.309823131403725 3290 701009 SGTC_369 0957-0393 4.5 µM -0.496724504705267 0.327709953075397 no 2253 0.309691669814101 3304 6997992 SGTC_574 1315-0397 40 µM -0.497398508328915 0.327495590769076 no 2254 0.309454028638812 3310 6794277 SGTC_1736 st036774 51 µM -0.498409965607657 0.327174010304866 no 2255 0.309097557050569 3454 1272247 SGTC_206 4546-0025 72.014 µM -0.498520619121927 0.327138837152915 no 2256 0.30905856992536 3373 6620745 YIL048W NEO1 SGTC_1634 st006576 41 µM -0.499683535523498 0.326769276762988 no 2257 0.308648963708736 3413 3915356 SGTC_942 3253-1115 227 µM -0.500236185658598 0.326593710939261 no 2258 0.308454390855369 3423 46497897 SGTC_334 1502-1024 68.5 µM -0.502419156650694 0.325900600689412 no 2259 0.30768635327127 3379 3296216 SGTC_2782 7736369 71.43 µM -0.502577239654115 0.325850431425048 no 2260 0.307630767376403 3292 2950836 YOL077C BRX1 SGTC_2275 7947463 200 µM -0.50290164964976 0.325747486457546 no 2261 0.307516710627332 3377 1225414 SGTC_370 0180-0345 38.7 µM -0.504183258551674 0.325340923710477 no 2262 0.307066301907697 3239 3989527 SGTC_1547 harmine 94.2 µM -0.504911389948873 0.325110032272847 no 2263 0.306810536928784 3370 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2285 7945142 200 µM -0.50755075882832 0.324273648192489 no 2264 0.30588421539107 3368 2970608 SGTC_422 cantharidin 155 µM -0.507875858163779 0.324170689341004 no 2265 0.30577020314721 3283 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1078 idebenone 36.1 µM -0.509249572760332 0.323735782899105 no 2266 0.305288649749038 3355 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2160 5660466 132.927 µM -0.51203100703007 0.32285594146873 no 2267 0.304314654453415 3374 2859134 SGTC_66 0109-0187 42.4 µM -0.512427374417242 0.322730640478068 no 2268 0.304175968282602 3415 759417 SGTC_3184 9108758 49.47 µM -0.513476555379689 0.32239906703369 no 2269 0.303809003208772 3345 902885 SGTC_2709 st078560 56 µM -0.513959237258004 0.322246572136399 no 2270 0.303640245126968 3446 17250903 SGTC_2691 st077356 60.2 µM -0.515135852947611 0.321874966362751 no 2271 0.303229045267106 3438 2839272 SGTC_2628 lathosterol 100 µM -0.515253159668432 0.321837927611524 no 2272 0.303188062944133 3431 6710616 SGTC_491 tetrandrine 80.3 µM -0.516149967257136 0.321554825601028 no 2273 0.302874835769565 3372 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2888 9058547 12.99 µM -0.516791235828242 0.321352455034598 no 2274 0.302650949349504 3307 16476514 SGTC_223 busulfan 5 mM -0.518104266065955 0.3209382564183 no 2275 0.302192761968059 3389 2478 A DNA alkylator. SGTC_801 0866-0028 10.1 µM -0.520075366951108 0.320316886069393 no 2276 0.301505523243484 3333 6849771 SGTC_3083 9117465 49.47 µM -0.521846933821299 0.319758846361486 no 2277 0.300888454284402 3376 16420915 SGTC_2444 5485484 36.41 µM -0.523216721076288 0.319327645786393 no 2278 0.300411723292729 3417 6790631 SGTC_2787 5284540 71.43 µM -0.524016844647322 0.319075884786687 no 2279 0.300133411968253 3327 736958 SGTC_2477 5967686 25.23 µM -0.524521293048434 0.318917201635287 no 2280 0.299958006897685 3281 776118 SGTC_686 1319-0111 510 µM -0.525881483819458 0.318489495059249 no 2281 0.299485277369241 3468 4562600 SGTC_2876 9059903 25.97 µM -0.526118754526613 0.318414910979817 no 2282 0.299402849374931 3407 6916095 SGTC_1491 4138-0063 26.5 µM -0.528638865692441 0.317623189591862 no 2283 0.298527996819525 3381 23883227 SGTC_104 0074-0074 590.992 µM -0.529879591452815 0.317233707471185 no 2284 0.298097708483393 3316 3943124 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.529893352817015 0.317229388709699 no 2285 0.298092937575598 3318 390807 SGTC_1394 3474-0001 65.7 µM -0.530745580243834 0.316961980677423 no 2286 0.297797547875794 3331 5017666 YIL048W NEO1 SGTC_2350 9023895 38.85 µM -0.531809022775916 0.31662843258275 no 2287 0.297429136477459 3426 2997209 SGTC_61 0978-8327 98.565 µM -0.533462876693838 0.316109998532089 no 2288 0.296856601168316 3439 6150059 YHR072W ERG7 SGTC_519 k048-0011 62.8 µM -0.533537519929977 0.316086608611293 no 2289 0.296830772884896 3385 6836379 SGTC_1489 4065-0444 182 µM -0.533848203320098 0.31598926195368 no 2290 0.296723280308965 3413 2877968 SGTC_2754 granisetron 64.02 µM -0.536186810119275 0.315256914379416 no 2291 0.295914724193113 3455 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1390 3413-2614 145 µM -0.537518963716389 0.314840067231508 no 2292 0.295454594652131 3393 3421432 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.539253503454363 0.314297661957664 no 2293 0.294855973526819 3472 688801 SGTC_208 k072-0098 12.366 µM -0.539393505700004 0.314253899531893 no 2294 0.294807680604808 3417 5948901 SGTC_589 1227-0070 34.1 µM -0.542487282654976 0.313287502399273 no 2295 0.293741432982705 3456 2841384 SGTC_2920 7982904 15.77 µM -0.542688823892134 0.313224591716842 no 2296 0.293672035223479 3385 6456808 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.543148511541053 0.313081121502795 no 2297 0.293513776947668 3367 689007 SGTC_1216 1165-0504 9.65 µM -0.543496874147489 0.31297241509104 no 2298 0.293393871247878 3459 6304004 SGTC_731 3966-0296 387 µM -0.54406636345848 0.312794741195371 no 2299 0.293197903078207 3413 660956 SGTC_1248 0469-0687 58.6 µM -0.544412916417718 0.312686642069964 no 2300 0.293078679717097 3409 4017482 SGTC_3188 9110789 49.47 µM -0.544676301402582 0.312604496031178 no 2301 0.292988083375562 3485 849217 SGTC_316 k060-0003 58.6 µM -0.551522192031027 0.310472634984935 no 2302 0.290637879047363 3466 6152314 SGTC_665 3914-0008 307 µM -0.551724867221232 0.310409616880661 no 2303 0.290568434965187 3373 1069549 SGTC_1141 3253-0389 52.6 µM -0.55211255140195 0.310289089154748 no 2304 0.290435621533713 3439 5402031 SGTC_842 0271-0008 11.1 µM -0.552206716841505 0.310259816992355 no 2305 0.290403366485448 3490 1221709 SGTC_2768 sulfasalazine 50.2 µM -0.553390039147277 0.309892073266636 no 2306 0.289998179084848 3506 5384001 An antioxidant and salicylic acid derivative. SGTC_2179 6298986 200 µM -0.553538451894932 0.309845964115989 no 2307 0.289947379033859 3446 738374 SGTC_203 k066-0004 30.888 µM -0.555901607446454 0.309112177928416 no 2308 0.289139059653573 3497 6795412 SGTC_3090 9117696 49.47 µM -0.558987319459646 0.308155175530686 no 2309 0.288085187171978 3366 7923821 SGTC_1015 4130-4525 82 µM -0.559312538542078 0.30805438789666 no 2310 0.287974219801634 3351 1363237 SGTC_2312 7706453 155.7 µM -0.559421303785612 0.308020684027877 no 2311 0.287937112727802 3400 976098 SGTC_3168 9103419 49.47 µM -0.560820047915697 0.307587389499309 no 2312 0.287460109199286 3420 16649256 SGTC_2345 9052315 157.45 µM -0.562224690491523 0.307152537755491 no 2313 0.286981470572579 3450 6469265 SGTC_773 4358-1457 44.6 µM -0.563032815753047 0.306902479691811 no 2314 0.286706269235554 3483 1186886 SGTC_49 0717-0965 32.132 µM -0.563925761803597 0.306626279989567 no 2315 0.286402328371904 3587 5889349 YGL099W LSG1 SGTC_1149 3909-7961 23.3 µM -0.568336990605973 0.305263443259642 no 2316 0.284903083085719 3430 735261 SGTC_595 3909-8003 73.7 µM -0.570867019225642 0.304483012838964 no 2317 0.284044894426037 3500 699517 SGTC_1886 st057356 49.9 µM -0.573725654359155 0.303602288168783 no 2318 0.283076732595965 3362 24207747 SGTC_604 1000-0114 314 µM -0.575187261873868 0.303152417431764 no 2319 0.282582328375571 3509 1572745 SGTC_3180 9109287 49.47 µM -0.577232926091829 0.302523280016988 no 2320 0.281891058620759 3492 18891271 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.577656887393632 0.302392965345261 no 2321 0.281747895836631 3437 115019 SGTC_2081 5214970 32.255 µM -0.577819752328769 0.302342911596484 no 2322 0.281692909104538 3462 2063512 SGTC_2967 9089538 49.85 µM -0.578231316799862 0.302216440870126 no 2323 0.281553979080246 3522 728216 SGTC_1001 4048-4355 44.4 µM -0.578569809451734 0.302112442371876 no 2324 0.281439740366179 3469 21824233 SGTC_2356 9061756 188.97 µM -0.57868677300584 0.302076510219594 no 2325 0.281400271249905 3439 20104043 SGTC_3237 9133362 49.47 µM -0.578703960615854 0.302071230208139 no 2326 0.281394471550559 3461 43845137 SGTC_1450 4112-4260 37.6 µM -0.57921806120897 0.301913318336154 no 2327 0.281221022745151 3509 1633175 SGTC_1218 1348-1416 30.7 µM -0.580720911249261 0.301451913604979 no 2328 0.280714282916679 3477 6787668 SGTC_386 1509-0011 3.07 µM -0.580830783368995 0.301418193140298 no 2329 0.280677252919613 3508 3107280 SGTC_2977 9011197 71.43 µM -0.58126606649144 0.301284618623078 no 2330 0.280530573483175 3538 2704722 SGTC_2557 derrustone 83.84 µM -0.58160293146756 0.301181263799803 no 2331 0.280417083950323 3505 629853 An antioxidant. SGTC_974 1326-0144 138 µM -0.581645117211537 0.30116832175689 no 2332 0.280402873174219 3449 5411856 SGTC_729 4092-0585 94.1 µM -0.58281829162943 0.300808507375798 no 2333 0.280007814979865 3419 2169061 SGTC_1102 cgs 12066b 26.1 µM -0.583183878419115 0.300696420996233 no 2334 0.279884761379444 3448 6438352 A 5-HT1B full agonist. SGTC_3234 9132280 49.47 µM -0.584484429978784 0.300297833778357 no 2335 0.279447218815239 3506 17612295 SGTC_1255 0566-0045 221 µM -0.584649294549004 0.300247323882095 no 2336 0.279391777415181 3523 2788469 SGTC_1692 fluoroquinolonic acid 71 µM -0.584933758753674 0.300160181032311 no 2337 0.279296129076498 3499 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2985 9022375 71.43 µM -0.586748396223264 0.299604553844335 no 2338 0.278686349538868 3565 4939335 SGTC_2617 dihydrotanshinone i 20.83 µM -0.588320096182019 0.299123689119806 no 2339 0.278158729583517 3462 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_672 1441-0018 53.7 µM -0.589992480276461 0.298612404947693 no 2340 0.277597845469643 3446 251141 SGTC_287 k060-0039 29.6 µM -0.593023468886533 0.297686780199889 no 2341 0.276582723049501 3531 5861974 SGTC_1930 st074634 34.3 µM -0.595520753459076 0.296925126915119 no 2342 0.275747715407241 3479 684253 YOR116C RPO31 SGTC_1348 1493-0373 93.8 µM -0.595608324536285 0.296898434574168 no 2343 0.275718457095918 3470 3010129 SGTC_65 0798-0905 34.986 µM -0.595703457235369 0.296869438636805 no 2344 0.275686674105766 3667 3602145 SGTC_876 0720-0963 56.8 µM -0.597550410818378 0.296306754077348 no 2345 0.27506998046211 3542 765861 SGTC_2208 7283366 200 µM -0.598995703500477 0.295866779101492 no 2346 0.274587874844532 3526 898663 SGTC_1772 st048439 82.2 µM -0.599467834441588 0.295723118379318 no 2347 0.27443047671237 3490 2927068 YDL195W SEC31 SGTC_2115 tiliquinol 12.7705 µM -0.599917611493423 0.295586289353389 no 2348 0.274280572306006 3460 71208 A bioactive hydroxyquinoline. SGTC_3144 9087057 49.47 µM -0.600478940487353 0.295415565369777 no 2349 0.274093545931187 3485 17249618 SGTC_1175 0741-0056 27.6 µM -0.604532761122826 0.294183975295029 no 2350 0.272744747447977 3580 765927 SGTC_1553 gossypol 38.6 µM -0.60629084643001 0.293650590427648 no 2351 0.272160817945072 3471 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3117 9124945 49.47 µM -0.606682224822223 0.293531911227093 no 2352 0.272030910355162 3437 17592065 SGTC_2218 6965428 192.983 µM -0.607646690092681 0.293239547503845 no 2353 0.271710913577158 3513 675684 SGTC_2743 auranofin 4.32 µM -0.608193936512911 0.293073717702854 no 2354 0.271529427834047 3472 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_673 1082-0474 110 µM -0.608804134325776 0.292888863312288 no 2355 0.271327136459372 3531 3098046 SGTC_1678 st019265 80.2 µM -0.6093947456501 0.292709994043057 no 2356 0.271131409908371 3582 5367020 SGTC_1984 st072354 53.1 µM -0.609623764753608 0.292640648240954 no 2357 0.271055532717717 3462 5762938 SGTC_3048 9093155 49.47 µM -0.610045895186291 0.292512849327373 no 2358 0.270915702836346 3522 25236002 SGTC_1490 4089-0339 670 nM -0.610180743119368 0.292472029926104 no 2359 0.270871042308877 3513 742542 SGTC_2525 harmine 47.85 µM -0.610641913749375 0.292332450404575 no 2360 0.270718334160778 3465 5280953 A monoamine oxidase inhibitor SGTC_1211 1056-0033 32.3 µM -0.612544233934077 0.291757015208306 no 2361 0.270088870642429 3557 6741922 SGTC_1454 4239-0054 42.6 µM -0.615264819976033 0.290934980204741 no 2362 0.269189923278481 3637 1340767 SGTC_1685 st024049 53.0905 µM -0.615458286425855 0.290876564854778 no 2363 0.269126054499077 3529 1941139 SGTC_2523 spermine 47.74 µM -0.615715648668927 0.290798865277447 no 2364 0.2690411036871 3516 1103 A DNA binding polyamine. SGTC_3347 9188721 44.724 µM -0.615796836467749 0.290774356090099 no 2365 0.269014307795787 3527 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_3202 9113761 49.47 µM -0.615993845602809 0.290714886467452 no 2366 0.268949290844251 3535 4798415 SGTC_799 1310-0557 151 µM -0.618070203540099 0.2900884585421 no 2367 0.268264531302901 3576 5354492 SGTC_111 0083-0039 52.457 µM -0.61854410666579 0.289945572806619 no 2368 0.268108366400345 3469 759313 SGTC_1815 st051655 58.2 µM -0.61882093216965 0.289862122886176 no 2369 0.268017165497866 3524 5984156 SGTC_2125 5246583 200 µM -0.619461240119259 0.289669143214688 no 2370 0.267806274195542 3603 835267 SGTC_2594 a-mangostin 100 µM -0.620594401994207 0.289327772278597 no 2371 0.267433261927946 3563 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1783 st039459 87.517 µM -0.624420222438522 0.288176622723519 no 2372 0.266175823879787 3601 729761 SGTC_350 k064-0020 19.8 µM -0.624956282681193 0.288015500521395 no 2373 0.265999875562374 3567 2790705 SGTC_1752 st044819 83.042 µM -0.626862116476755 0.287443013724831 no 2374 0.265374810907961 3490 441209 YML126C ERG13 SGTC_330 1488-0319 80.1 µM -0.627294498349554 0.28731320697402 no 2375 0.265233104548869 3531 6846614 SGTC_178 4092-0806 87.505 µM -0.630495198559764 0.286353178129945 no 2376 0.264185321609924 3560 2169044 SGTC_902 1120-0002 2.07 µM -0.631797697134533 0.285962938696411 no 2377 0.263759539309256 3577 3280475 SGTC_262 fenpropimorph 62.5 µM -0.632357668144679 0.285795244447257 no 2378 0.26357659434327 3533 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2490 carminic acid 95.39 µM -0.633286465324736 0.285517201168244 no 2379 0.263273295089162 3543 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2212 7123476 200 µM -0.636007007815546 0.28470352562489 no 2380 0.262385927223013 3533 1085715 SGTC_3314 9135860 59.4275 µM -0.637136875592498 0.284365923858569 no 2381 0.262017845344276 3592 25252478 SGTC_3009 9080819 71.4286 µM -0.637198104697806 0.284347634215437 no 2382 0.261997906039167 3555 17027216 SGTC_632 0781-2353 4.65 µM -0.637561138269685 0.284239204617001 no 2383 0.261879699859258 3590 6811515 YHR007C ERG11 SGTC_878 0828-0289 13.7 µM -0.638071117003877 0.284086919347495 no 2384 0.261713693552324 3595 745350 YLR208W SEC13 SGTC_2020 4017018 200 µM -0.640927072486955 0.28323482158479 no 2385 0.260785032838069 3583 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2191 5911152 200 µM -0.640959288731718 0.283225216600458 no 2386 0.260774566876798 3545 2875902 SGTC_2248 tofa 1.1 µM -0.641390847460347 0.283096566304998 no 2387 0.260634388976417 3535 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2808 7946468 45.46 µM -0.641819825070505 0.282968713255928 no 2388 0.260495087917102 3568 2970879 SGTC_396 dithiazanine 1.25 µM -0.643316895308154 0.282522741795008 no 2389 0.260009247764608 3540 10578 An antihelmenthic. SGTC_1795 st049545 62.3 µM -0.64377877165441 0.282385218856265 no 2390 0.259859450657221 3554 5291882 SGTC_2801 7907800 81.82 µM -0.64538558732174 0.281907043106631 no 2391 0.259338670513362 3589 6620925 SGTC_2019 4016004 108 µM -0.645810942122061 0.281780526186107 no 2392 0.259200900386673 3552 45595336 SGTC_2989 9073649 71.4286 µM -0.646662861679483 0.281527214783516 no 2393 0.258925082038926 3591 21367202 SGTC_2396 5342950 42.78 µM -0.646908984075875 0.281454052733328 no 2394 0.258845425477689 3576 1886677 SGTC_474 dl-dihydrosphingosine 5 µM -0.647880380116042 0.28116538629332 no 2395 0.258531160735006 3633 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2311 7694451 200 µM -0.649182433603843 0.280778683932327 no 2396 0.258110232297859 3530 2163142 SGTC_154 3389-1638 511.116 µM -0.649409803439933 0.280711182791262 no 2397 0.258036764538164 3513 5238686 SGTC_1655 st012546 55.1 µM -0.652351749397948 0.2798384918007 no 2398 0.257087141695303 3572 720985 YLR208W SEC13 SGTC_2433 5607874 27.82 µM -0.653004029475286 0.279645179566531 no 2399 0.256876840392198 3602 2252428 SGTC_1619 st003326 88.7 µM -0.654558126853596 0.279184862635173 no 2400 0.256376145583066 3581 2849032 SGTC_3338 9144300 39.5675 µM -0.655939559421666 0.278775997727273 no 2401 0.255931506799279 3569 4901274 SGTC_1326 1431-2094 10.8 µM -0.656438566988368 0.278628377309264 no 2402 0.255770991272665 3588 616278 SGTC_1876 myriocin 605 nM -0.658519792037692 0.278013103415596 no 2403 0.255102091726308 3637 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_941 3237-0776 460 µM -0.658890776611966 0.27790349866556 no 2404 0.254982954544113 3621 760008 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.659631334197442 0.277684769295874 no 2405 0.254745220572864 3656 804 An inhibitor of viral and cellular DNA polymerases. SGTC_956 1185-0240 191 µM -0.659755427363142 0.277648125653948 no 2406 0.254705395511052 3611 1416193 SGTC_2544 sphondin 68.51 µM -0.660152136126214 0.277530996825521 no 2407 0.254578102146047 3631 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_3242 9133940 49.47 µM -0.664462632772213 0.27625987546601 no 2408 0.253197128729211 3659 17248444 SGTC_1991 st073000 8.92 µM -0.66511831026805 0.276066773490214 no 2409 0.252987412082724 3680 4301969 YIL048W NEO1 SGTC_107 0358-0022 2.6945 µM -0.666060617407478 0.275789373029721 no 2410 0.252686177878059 3590 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1916 st067606 49.2 µM -0.666120814941379 0.275771656474623 no 2411 0.252666940514013 3625 19590279 SGTC_1338 1486-1223 76 µM -0.668845988457304 0.274970205167474 no 2412 0.251796863586569 3634 3444526 SGTC_1973 st070275 50.2 µM -0.669825494800551 0.274682420965299 no 2413 0.251484519634655 3573 17118334 SGTC_2847 9005661 71.43 µM -0.67327234279008 0.27367090113102 no 2414 0.250387022333309 3542 2991449 SGTC_1483 3453-0561 55.9 µM -0.673601548493327 0.273574388171933 no 2415 0.2502823342182 3639 4546991 SGTC_1994 st072947 40.9 µM -0.674199039974717 0.273399265135288 no 2416 0.250092389954153 3651 5286565 YDL195W SEC31 SGTC_3231 9132313 49.47 µM -0.675814243070238 0.27292613176902 no 2417 0.249579295264652 3639 4905967 SGTC_1381 2324-0066 62.1 µM -0.676829297495596 0.272629004849568 no 2418 0.249257133631438 3636 10885928 SGTC_2205 7238770 200 µM -0.677549868747063 0.272418176585768 no 2419 0.249028570401025 3654 279867 SGTC_1494 4358-1428 177 µM -0.678866339988389 0.27203320621908 no 2420 0.248611277470993 3669 1564571 SGTC_699 0375-0592 111 µM -0.679027680742894 0.271986044609535 no 2421 0.248560161573173 3675 762578 SGTC_1213 1315-0166 115 µM -0.679220970062685 0.271929549450812 no 2422 0.248498931119549 3614 768401 SGTC_2831 7999036 19.48 µM -0.680074137188864 0.27168025307436 no 2423 0.248228759737023 3645 2988270 SGTC_2871 9038510 12.99 µM -0.680742401990443 0.271485064853057 no 2424 0.248017250588141 3662 4945164 SGTC_2585 alliin 100 µM -0.681437626035587 0.271282076481363 no 2425 0.247797310801208 3718 87310 A garlic compound which reacts with lipids. SGTC_3218 9131285 49.47 µM -0.681501553908989 0.271263414908657 no 2426 0.247777091926989 3663 17156417 SGTC_584 0986-0246 15.4 µM -0.681892173021669 0.271149400819955 no 2427 0.247653567477826 3731 53315 YDR232W HEM1 SGTC_732 3970-1727 52.7 µM -0.682251066242038 0.271044667966586 no 2428 0.247540104621682 3646 1275699 SGTC_2601 securinine 100 µM -0.682949353137365 0.270840950492368 no 2429 0.247319423234143 3624 442872 A GABA receptor antagonist. SGTC_1898 st060199 18.6 µM -0.68321801625551 0.270762591363553 no 2430 0.247234544969361 3666 688866 SGTC_2374 9071832 200 µM -0.683953739481835 0.270548065968049 no 2431 0.247002188981659 3616 17381698 SGTC_2968 9090663 33.37 µM -0.684385368262752 0.270422249292637 no 2432 0.246865926452173 3638 25236811 SGTC_969 1313-0238 134 µM -0.685276497515221 0.27016258408435 no 2433 0.246584729807595 3671 5212874 SGTC_2756 carbadox 75.1 µM -0.686984521078178 0.269665233748026 no 2434 0.246046241364828 3672 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1939 st074455 53.6 µM -0.687071203088501 0.269640005506532 no 2435 0.246018929964926 3672 1644229 SGTC_1671 st016596 74.5 µM -0.687501244852158 0.269514862104222 no 2436 0.245883458284944 3694 2829167 SGTC_219 mitoxanthrone 164.414 µM -0.687534093923583 0.269505304125792 no 2437 0.24587311182247 3638 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2522 biochanin a 4.94 µM -0.687866548281764 0.269408580614842 no 2438 0.245768411920604 3613 5280373 A possible chelator. SGTC_653 0203-0016 55.2 µM -0.690149708313642 0.268744793757433 no 2439 0.245050023072565 3682 295302 SGTC_1101 ebselen 5.29 µM -0.690383933244925 0.268676743653832 no 2440 0.24497638889978 3727 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_432 NS 1619 61.3 µM -0.692209047274164 0.268146784304635 no 2441 0.244403028940052 3668 4552 A K+/calcium channel activator. SGTC_449 xestospongin c 11.1929 µM -0.692407831220112 0.268089095088412 no 2442 0.244340624619376 3635 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2858 9025781 8.96 µM -0.69347282133817 0.26778013005635 no 2443 0.244006438161735 3680 4894980 YPL153C RAD53 SGTC_2390 9097792 176.6 µM -0.69405380589451 0.267611655880364 no 2444 0.243824233263707 3657 4497149 SGTC_710 3448-4187 58 µM -0.694182990566897 0.267574202110615 no 2445 0.243783729121702 3696 3946412 SGTC_2785 7756463 72.73 µM -0.696555663639727 0.266886776974497 no 2446 0.243040455255103 3658 2201551 SGTC_1814 st052110 31.539 µM -0.697696055598682 0.266556693510472 no 2447 0.242683647722225 3651 674163 SGTC_1525 8-methoxypsoralen 92.5 µM -0.698094697701131 0.266441356316333 no 2448 0.242558986914219 3702 4114 Related to psoralen; DNA damaging agent. SGTC_505 gw-5074 63.9 µM -0.698260295388131 0.266393452160487 no 2449 0.242507212461735 3697 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2995 9067767 71.4286 µM -0.699811811037635 0.265944840961405 no 2450 0.242022418837086 3671 11673567 SGTC_251 melphalan 456.522 µM -0.70136014358485 0.265497532031906 no 2451 0.241539144288859 3731 460612 A DNA alkylator. SGTC_994 3910-0338 138 µM -0.701626866711704 0.265420515026176 no 2452 0.241455946061759 3754 3479481 SGTC_2640 pentamidine 10.38 µM -0.702643322200228 0.265127114789312 no 2453 0.241139028576006 3705 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2845 9003024 42.97 µM -0.702745116513305 0.26509774090174 no 2454 0.241107302906319 3708 2990173 SGTC_863 0466-0191 129 µM -0.703421083752818 0.264902724938451 no 2455 0.240896685521154 3690 765160 YPR165W RHO1 SGTC_1034 k072-0165 12.7 µM -0.70378168334241 0.264798722099661 no 2456 0.240784371109726 3675 5835461 SGTC_1862 st057513 3.81 µM -0.704681420439334 0.264539313704939 no 2457 0.240504258131185 3667 5393163 SGTC_2827 7993847 71.43 µM -0.707058160385846 0.263854684553417 no 2458 0.239765167668693 3669 2985692 SGTC_1087 pterostilbene 9.05 µM -0.707755015062486 0.263654124257086 no 2459 0.239548703223793 3705 5281727 Similar to reservatol, lowers cholesterol. SGTC_265 mycophenolic acid 32.932 µM -0.708871036313913 0.263333086589428 no 2460 0.239202255147645 3769 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_581 0958-0271 211 µM -0.709097726123674 0.263267900789701 no 2461 0.239131916975163 3704 4591145 SGTC_894 0960-0238 55.9 µM -0.709877745011725 0.263043665402228 no 2462 0.238889976151585 3653 6741907 YDL195W SEC31 SGTC_3264 9137442 49.47 µM -0.710256988541971 0.262934677908441 no 2463 0.238772393419357 3715 17015726 SGTC_18 0111-0177 500 nM -0.710285526688875 0.262926477513128 no 2464 0.238763546577728 3777 721752 SGTC_1418 3966-3099 2.4 µM -0.712695472354015 0.262234455159765 no 2465 0.238017109396408 3695 740335 SGTC_2767 sibutramine 71.45 µM -0.713954613530537 0.261873260881268 no 2466 0.237627622474739 3735 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2432 5630864 12.22 µM -0.714833308982123 0.261621351607358 no 2467 0.237356025175622 3676 5714970 SGTC_1050 3232-1156 69.3 µM -0.716203391740692 0.261228816990427 no 2468 0.236932884538826 3685 700529 SGTC_1463 k081-0032 34.1 µM -0.716756814661032 0.261070344788931 no 2469 0.236762081328798 3546 977755 SGTC_1567 st069303 68.4 µM -0.717420381342355 0.260880398184904 no 2470 0.236557373696498 3750 5581319 SGTC_1048 3161-0300 24.5 µM -0.717911392761241 0.260739891465189 no 2471 0.236405961380801 3711 2165101 SGTC_2916 7875993 68.79 µM -0.719102863613087 0.260399104815215 no 2472 0.236038771528 3676 1299250 SGTC_2863 9028737 58.44 µM -0.72056108746271 0.259982333426848 no 2473 0.235589801191274 3698 6460917 SGTC_3248 9135562 49.47 µM -0.720894641289204 0.259887049590292 no 2474 0.235487170051994 3730 17650701 SGTC_2185 6113692 200 µM -0.721012204977742 0.25985347034139 no 2475 0.235451002774833 3692 874150 SGTC_618 k072-0232 33.2 µM -0.723077153264481 0.259264032520932 no 2476 0.234816242387581 3705 5872756 YGL099W LSG1 SGTC_1729 st035615 45.989 µM -0.725386380857581 0.25860568474801 no 2477 0.234107512904027 3775 17385451 SGTC_427 1354-0053 47.3 µM -0.727889328259062 0.257893087370644 no 2478 0.233340668180187 3787 6813657 SGTC_694 1315-0438 43.2 µM -0.729039901534434 0.257565857514815 no 2479 0.232988627516487 3686 6793154 SGTC_1245 0418-0076 17.2 µM -0.729230420596839 0.25751169358198 no 2480 0.232930362917979 3739 6790114 SGTC_475 α-linolenic acid 10 µM -0.729784178512338 0.25735429565342 no 2481 0.232761058459026 3781 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3306 9127676 59.7925 µM -0.730311321235185 0.257204509182302 no 2482 0.232599954810734 3725 41905287 SGTC_971 1315-0384 26.7 µM -0.733014876375121 0.256437012720481 no 2483 0.231774678060776 3753 6769120 SGTC_2825 7998094 58.44 µM -0.733848451620226 0.25620061482974 no 2484 0.2315205535302 3724 2987815 SGTC_305 1682-2595 20.8 µM -0.736989394019754 0.255310880582833 no 2485 0.230564399573038 3758 226033 SGTC_2978 9011784 42.97 µM -0.73716477206504 0.255261248925842 no 2486 0.230511076770443 3777 2994934 SGTC_2598 perillyl alcohol 100 µM -0.7384828778594 0.254888388947248 no 2487 0.230110534054973 3748 10819 An apoptosis inducer. SGTC_644 1498-1197 63.3 µM -0.739122248018384 0.254707629444892 no 2488 0.229916384180283 3792 6741615 SGTC_2182 6325192 200 µM -0.739671029268007 0.254552534330687 no 2489 0.229749815507059 3675 736248 SGTC_3081 9117243 49.47 µM -0.741828131193172 0.253943379617017 no 2490 0.22909573705112 3754 45595589 SGTC_2327 6189656 200 µM -0.743792342428282 0.253389362418893 no 2491 0.228501056776563 3799 5349088 SGTC_3043 9092303 49.47 µM -0.744573918845457 0.253169091061972 no 2492 0.228264669817985 3751 25236084 SGTC_730 1436-0052 41.2 µM -0.745003353140186 0.253048106654355 no 2493 0.228134846406206 3762 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2114 5491910 81.25 µM -0.745019059679661 0.253043682231916 no 2494 0.228130098908072 3810 2849228 SGTC_1748 st037455 53.6035 µM -0.745056304094325 0.25303319090319 no 2495 0.228118841539654 3743 580690 SGTC_3124 9127567 49.47 µM -0.745874573329618 0.252802751509804 no 2496 0.227871593135725 3693 17592030 SGTC_2588 indole-3-carbinol 100 µM -0.746456889169483 0.252638828169867 no 2497 0.227695732332385 3761 3712 Induces cell cycle arrest. SGTC_1787 fluconazole 80 µM -0.74655449351363 0.252611357786609 no 2498 0.227666263060332 3639 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_907 3448-6986 75.5 µM -0.746589703830219 0.25260144835885 no 2499 0.227655632683495 3771 590582 SGTC_666 0272-0154 136 µM -0.747480355819142 0.252350855521345 no 2500 0.227386828129448 3797 6870312 SGTC_774 k060-0086 136 µM -0.748115753498356 0.252172160874752 no 2501 0.227195170315406 3763 5911235 SGTC_2379 9035213 200 µM -0.748375665848587 0.252099084243349 no 2502 0.227116798050233 3735 646551 SGTC_2318 6029776 164 µM -0.74986879709249 0.251679493848462 no 2503 0.226666864427418 3745 818325 SGTC_2010 4012422 159 µM -0.750348206060998 0.251544851607133 no 2504 0.226522508190781 3758 952393 SGTC_888 0916-0002 6.97 µM -0.750375486876482 0.251537190921463 no 2505 0.226514295145795 3835 2802138 YIL048W NEO1 SGTC_3217 9129673 49.47 µM -0.750509725177605 0.251499497457204 no 2506 0.226473884389231 3743 17248312 SGTC_1878 temozolomide 1 mM -0.753900769010001 0.25054829965764 no 2507 0.22545440440181 3687 5394 DNA alkylating agent. SGTC_979 1426-2828 121 µM -0.75409024120742 0.25049520842915 no 2508 0.225397518408158 3870 747872 SGTC_42 0133-0086 60.653 µM -0.755347402972694 0.250143095332578 no 2509 0.225020281618296 3682 162923 Model of phenazepam hydroxylation. SGTC_1760 st045453 10.4495 µM -0.755687135018227 0.250047986306953 no 2510 0.224918399596135 3807 3323419 YIL048W NEO1 SGTC_3153 9100258 49.47 µM -0.756032295613117 0.249951377194431 no 2511 0.224814916392977 3708 25236848 SGTC_2003 4023581 200 µM -0.758147927433527 0.249359653129452 no 2512 0.224181215257192 3811 16641307 SGTC_2693 st077581 40.7 µM -0.758491019942752 0.24926376331909 no 2513 0.224078543469865 3824 25238761 SGTC_2196 6573537 42.6665 µM -0.758556033360864 0.249245595140068 no 2514 0.224059090958562 3781 2903087 SGTC_276 colchicine 750 µM -0.759081046309309 0.249098904630364 no 2515 0.223902038229993 3809 2833 A microtubule depolymerizer. SGTC_2586 curcumin 80 µM -0.76015388226836 0.248799293264804 no 2516 0.22358130396327 3788 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_612 0302-0167 22.4 µM -0.76062672016288 0.248667304560397 no 2517 0.223440027688358 3786 235821 SGTC_1427 4048-4900 550 nM -0.76239654219345 0.248173604899742 no 2518 0.222911684683833 3778 24132586 SGTC_2960 9079389 5.97 µM -0.762671029879531 0.248097082201878 no 2519 0.222829805976073 3747 16457355 SGTC_542 3381-0244 89.3 µM -0.763143012195295 0.247965530651234 no 2520 0.222689055391564 3778 1112843 SGTC_385 1494-0393 12.4 µM -0.765683020515758 0.247258215732466 no 2521 0.221932466249567 3782 3090647 SGTC_1610 st001799 48.1 µM -0.765792386962095 0.247227784752847 no 2522 0.221899922397058 3708 621897 SGTC_1779 st039427 55 µM -0.765981707146159 0.247175111551136 no 2523 0.221843593388112 3788 1124498 SGTC_749 1000-0129 128 µM -0.766111180813001 0.24713909247421 no 2524 0.221805075398109 3815 708470 SGTC_3308 9128332 17.569 µM -0.769512019273388 0.2461939984043 no 2525 0.220794706055634 3767 17332805 YDL196W YDL196W SGTC_2103 5378138 10 µM -0.771110401895969 0.245750477790286 no 2526 0.220320747786029 3816 244142 SGTC_869 0564-0080 44.1 µM -0.771130301933477 0.245744958615369 no 2527 0.220314850632483 3805 6843321 SGTC_1500 4488-1866 171 µM -0.777301605437693 0.244036593621927 no 2528 0.218490424043023 3892 2900003 SGTC_1920 st075728 45.7 µM -0.777564156911571 0.243964055407485 no 2529 0.218412999201651 3774 3400306 SGTC_746 1095-0025 46.6 µM -0.777909804222646 0.243868577059444 no 2530 0.218311094000322 3803 6749286 SGTC_512 prima-1 270 µM -0.778614950554165 0.243673856645046 no 2531 0.218103284740621 3813 322968 A re-activator of the apoptotic function of mutant p53. SGTC_312 4092-0653 6.84 µM -0.780071013944042 0.243272042384914 no 2532 0.217674538403651 3787 1148278 SGTC_2634 4'-methoxyflavone 100 µM -0.782133391783437 0.242703523435142 no 2533 0.217068092239826 3826 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_368 fentichlor 4.58 µM -0.782591785714991 0.242577259470487 no 2534 0.216933433357885 3828 7329 A pesticide. SGTC_2797 7859098 81.82 µM -0.784035028654322 0.242179952643557 no 2535 0.216509778381916 3833 972681 SGTC_485 niflumic acid 177 µM -0.7854038138037 0.24180346929817 no 2536 0.216108422698622 3864 4488 A COX2 inhibitor. SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.786020650974132 0.241633912558611 no 2537 0.215927694418513 3807 1273210 SGTC_2696 st077691 74.316 µM -0.78672092055332 0.241441500108297 no 2538 0.215722627301283 3814 757133 SGTC_1228 0124-0032 52.5 µM -0.787186694521938 0.241313565910913 no 2539 0.215586292479324 3885 X1228 SGTC_2402 5553605 200 µM -0.788143241874108 0.241050946463526 no 2540 0.215306462082342 3851 6758546 SGTC_990 3985-0011 41.3 µM -0.788324202727163 0.241001281267129 no 2541 0.215253547127867 3825 5399565 YGL099W LSG1 SGTC_1631 benzylvanillin 81.9 µM -0.788788597399792 0.240873852359862 no 2542 0.215117787532068 3883 75506 SGTC_3004 9076122 71.4286 µM -0.789019726019941 0.240810444823362 no 2543 0.215050238689452 3827 44782551 SGTC_249 wiskostatin 11.211 µM -0.789241560974346 0.240749595441897 no 2544 0.21498541756554 3804 2775510 A n-wasp and actin depolymerizer. SGTC_2192 5915882 198.485 µM -0.791740044794601 0.240064838893651 no 2545 0.214256133829119 3786 2876149 SGTC_2407 paclitaxel 400 µM -0.792455196218145 0.239869033819077 no 2546 0.214047653135563 4002 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2807 7945238 51.95 µM -0.794680508739481 0.239260311441559 no 2547 0.213399686591219 3872 17148797 SGTC_1023 4482-3888 16 µM -0.795268308841614 0.239099662881574 no 2548 0.213228722039705 3807 3303168 SGTC_2564 betulinic acid 100 µM -0.796436861449158 0.238780467087233 no 2549 0.212889080097448 3821 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2866 9034245 58.44 µM -0.798003187925871 0.238352983327624 no 2550 0.212434320065011 3798 6462273 SGTC_3001 9076041 71.4286 µM -0.799148450852227 0.238040682215868 no 2551 0.212102169193827 3821 16004211 SGTC_1008 4106-0037 6 µM -0.799264396003725 0.238009077704163 no 2552 0.212068559542744 3777 2905394 SGTC_1773 st048542 73.5835 µM -0.79929814785691 0.237999878003215 no 2553 0.212058776294933 3777 3237138 SGTC_992 3909-8734 162 µM -0.802579766221356 0.237106342788228 no 2554 0.211108833579747 3860 4288319 SGTC_336 4111-0029 111 µM -0.803546268098336 0.236843530710019 no 2555 0.210829532709462 3824 3131175 SGTC_1403 3909-7815 62.9 µM -0.803935758189879 0.236737665503699 no 2556 0.210717038687454 3784 6615483 SGTC_326 k292-0812 17.5 µM -0.804970613335904 0.236456513573188 no 2557 0.210418318971959 3791 3579357 SGTC_1082 camptothecin 424.86 nM -0.805933006369369 0.236195213335048 no 2558 0.210140739280006 3774 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1388 3346-4487 254 µM -0.80699933706696 0.235905878710712 no 2559 0.209833432544675 3901 3345614 SGTC_1746 st038117 42 µM -0.807593706223989 0.235744689393973 no 2560 0.209662255524364 3913 2898218 SGTC_2595 hexamethylquercetagetin 100 µM -0.807640776872884 0.235731926714779 no 2561 0.209648702790293 3818 386331 SGTC_2238 6671620 73.2395 µM -0.807720180694806 0.235710398121408 no 2562 0.209625841751681 3800 729941 SGTC_1846 st056244 14.8 µM -0.808793502135579 0.235419497117967 no 2563 0.209316967216606 3875 5393182 SGTC_2460 5552655 174.22 µM -0.809030552552349 0.23535527635485 no 2564 0.209248786281662 3856 5401989 SGTC_1622 st003707 19.4 µM -0.810154948723916 0.235050791139424 no 2565 0.208925563222066 3895 10140899 SGTC_3291 9121177 71.43 µM -0.810371131132639 0.234992274138517 no 2566 0.208863452358809 3857 17015612 SGTC_1796 st049173 110.4 µM -0.811088550488542 0.234798138279093 no 2567 0.208657410248387 3792 94134 SGTC_3199 9111318 49.47 µM -0.812376087997902 0.234449949152927 no 2568 0.208287931387102 3811 8548020 SGTC_976 1348-1067 47.6 µM -0.812975310213374 0.234287998792535 no 2569 0.208116106978955 3888 5310671 YGL099W LSG1 SGTC_452 diindolylmethane 8 µM -0.813622486942268 0.234113157455695 no 2570 0.207930625817725 3854 3071 Inhibits expression of several cancer promoting factors. SGTC_551 k048-0028 34.9 µM -0.814842117052125 0.233783858526322 no 2571 0.20758134465273 3828 6836383 SGTC_1061 3448-9325 110 µM -0.815114215774933 0.233710427179983 no 2572 0.207503467570736 3765 723482 SGTC_193 1273-0060 1.558 µM -0.815429670022785 0.233625311474305 no 2573 0.207413203368376 3708 2847393 YHR072W ERG7 SGTC_2910 7948405 25.97 µM -0.815455664389194 0.233618298454096 no 2574 0.207405766365466 3739 2971328 SGTC_1079 idarubicin 2.36 µM -0.815458844111795 0.233617440604737 no 2575 0.207404856655855 3796 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2035 5154463 94.595 µM -0.817251083751699 0.2331341948187 no 2576 0.206892477432854 3869 2769623 SGTC_2843 9000894 45.46 µM -0.817574246911295 0.233047118668628 no 2577 0.20680016885549 3782 2242070 SGTC_255 tunicamycin 200.472 nM -0.820183325600972 0.232344765628766 no 2578 0.206055803051818 3813 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_405 ebelactone b 50 µM -0.820829196507702 0.232171081894905 no 2579 0.205871782794084 3831 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_50 0929-0078 56.389 µM -0.820985462812962 0.2321290705554 no 2580 0.205827274360883 3747 1377751 SGTC_253 dyclonine 31.25 µM -0.821758911214109 0.231921195505984 no 2581 0.205607061575896 3941 3180 An oral anasthetic. SGTC_1220 1838-0075 193 µM -0.821844914323458 0.231898087376811 no 2582 0.205582583796916 3782 5529645 SGTC_621 3584-0052 32.1 µM -0.824328037077359 0.231231451725336 no 2583 0.204876596013982 3845 2273927 SGTC_2663 amphotericin b 100 µM -0.825576091261294 0.230896794940324 no 2584 0.204522301170887 3844 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1119 parthenolide 318.541 nM -0.826767691112363 0.230577528506512 no 2585 0.204184372937062 4007 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_120 rhodamine 6G 52.259 µM -0.829277152141732 0.229905973833944 no 2586 0.203473798223247 3907 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1205 4161-2785 76 µM -0.832431466813765 0.229063405652068 no 2587 0.202582723375311 3983 3498106 SGTC_1723 st034307 2.5525 µM -0.832511555316213 0.229042035297988 no 2588 0.202560129262841 3938 867466 SGTC_953 1188-0045 9.7 µM -0.83297584171881 0.22891816983133 no 2589 0.202429177106318 3928 6144426 SGTC_2329 6138490 200 µM -0.833730935542211 0.228716801100918 no 2590 0.202216310749651 4006 720019 SGTC_456 gingerol 170 µM -0.837571986983675 0.227694009076075 no 2591 0.201135565616887 3896 442793 A herb. SGTC_1067 clotrimazole 1.36 µM -0.839030730443794 0.227306251680874 no 2592 0.20072603258794 3897 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_489 paxilline 115 µM -0.839545698707659 0.227169453774606 no 2593 0.200581578115951 3848 105008 A toxic potassium channel blocker. SGTC_3024 9090631 49.47 µM -0.843243407386854 0.226188545981345 no 2594 0.199546163175124 3840 25236383 SGTC_295 k015-0027 31 µM -0.844065892443694 0.225970687501924 no 2595 0.199316292886115 3906 3887424 SGTC_529 4076-0302 30.3 µM -0.844462132745212 0.225865774384666 no 2596 0.199205607540391 3851 5816522 SGTC_1649 st011737 51.3 µM -0.845710668130274 0.225535378066177 no 2597 0.198857085180853 3881 1761035 SGTC_1656 st012921 11 µM -0.845850270794537 0.225498452425692 no 2598 0.198818138660175 3830 6732821 SGTC_1410 3909-8106 77.9 µM -0.84586995235016 0.225493246825737 no 2599 0.198812648245766 3930 1039210 SGTC_502 l-744,832 89.3 µM -0.846960943066615 0.225204795697321 no 2600 0.198508445813849 3892 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2056 5235370 200 µM -0.846985809386196 0.225198223634906 no 2601 0.198501515578473 3873 5511916 SGTC_2375 9072683 200 µM -0.847604967680328 0.225034617766997 no 2602 0.198329003424787 3914 16798029 SGTC_3178 9107506 49.47 µM -0.848076087838509 0.224910174508657 no 2603 0.198197798835091 3942 8897194 SGTC_1475 4092-1048 11.7 µM -0.848395926034704 0.224825713610574 no 2604 0.198108755377786 3925 2881759 SGTC_890 0929-0006 47.2 µM -0.848795781911919 0.224720147435717 no 2605 0.197997468853154 3870 1378169 SGTC_2504 purpurogallin 52.29 µM -0.849913364682691 0.224425242913169 no 2606 0.197686627318249 3826 5281571 An antioxidant. SGTC_1103 duloxetine 36.1 µM -0.852892006727151 0.223640321189994 no 2607 0.196859597389141 4007 60835 A selective serotonin reuptake inhibitor. SGTC_1630 st005209 31.3 µM -0.854687888246106 0.223167831861788 no 2608 0.196361978714352 3847 3367314 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.855056523732666 0.223070915669861 no 2609 0.196259928342254 3969 688788 SGTC_378 3970-0959 8.33 µM -0.857260718157848 0.222491921790897 no 2610 0.195650406367682 3937 6615653 SGTC_1459 k035-0031 35.7 µM -0.858396299298021 0.222193964156741 no 2611 0.195336835184446 3747 3877128 YMR208W ERG12 SGTC_2094 5332512 191.667 µM -0.858471102780513 0.22217434496229 no 2612 0.195316190214605 3962 755774 SGTC_1977 st070720 65.3 µM -0.858546940272668 0.222154455580692 no 2613 0.195295261222359 3944 682188 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.859599842316821 0.22187842315979 no 2614 0.195004830987753 3999 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1411 3909-8223 150 µM -0.863770663480942 0.220786913112927 no 2615 0.193856943276176 3924 X1411 SGTC_3260 9137109 49.47 µM -0.864430667389221 0.220614471343961 no 2616 0.19367567606656 3824 17478346 SGTC_320 4092-0846 5.34 µM -0.865023550679654 0.220459632245959 no 2617 0.193512931394419 3901 1359356 SGTC_622 1348-1566 26.3 µM -0.865044382101124 0.220454192985113 no 2618 0.193507214749505 3972 7340407 SGTC_105 0111-0055 734.78 µM -0.865243930297197 0.220402093155712 no 2619 0.193452459127286 3940 5179370 SGTC_2075 5212009 200 µM -0.865655871857468 0.220294562091142 no 2620 0.193339453095642 3803 780898 SGTC_2620 irigenin 100 µM -0.865909025816361 0.220228495034072 no 2621 0.193270026523468 3980 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_657 3534-0529 86.7 µM -0.867000670493588 0.219943732355719 no 2622 0.192970821160986 3974 1049549 SGTC_926 2268-1401 59.4 µM -0.867576682651865 0.219793561000629 no 2623 0.192813057924214 3899 2931578 SGTC_651 3253-0966 34.4 µM -0.868716279347704 0.219496631755165 no 2624 0.192501167475434 3958 781462 SGTC_1284 0929-0043 16 µM -0.869110846352818 0.219393878513675 no 2625 0.192393252349259 3896 1239883 SGTC_2223 6903751 107.57 µM -0.869641538173409 0.219255719209173 no 2626 0.192248165074054 3883 5598863 SGTC_968 1309-0633 340 µM -0.870185159917226 0.219114245617629 no 2627 0.192099612262629 3969 3761976 SGTC_462 ag-879 158 µM -0.870620545683637 0.21900097751131 no 2628 0.19198068722494 3965 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2541 muurolladie-3-one 83.07 µM -0.870894097806649 0.218929828585815 no 2629 0.191905989884312 3966 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1470 k295-0292 231 µM -0.872182848333325 0.218594812842833 no 2630 0.191554317421464 4009 5045612 SGTC_202 3594-0513 34.79 µM -0.872326671337257 0.218557443805349 no 2631 0.191515095700963 3920 708429 SGTC_1762 st045503 25.4615 µM -0.872949177359496 0.218395742621106 no 2632 0.191345389910739 4025 4645554 SGTC_1106 tegaserod maleate 11.7 µM -0.87295853421688 0.218393312624344 no 2633 0.191342839774629 3937 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2479 5617353 43.85 µM -0.873197887040645 0.218331157456073 no 2634 0.191277613172182 3973 2731746 SGTC_548 1436-0017 110 µM -0.873908275213768 0.218146743791703 no 2635 0.191084103883976 4009 9677137 SGTC_1279 0874-0590 65.2 µM -0.874406024934136 0.218017583644753 no 2636 0.19094858872831 3992 3523074 SGTC_575 k072-0246 11.9 µM -0.876375629304448 0.21750692727095 no 2637 0.1904129312878 3965 6796779 SGTC_3137 9097352 49.47 µM -0.876519966758569 0.217469532286629 no 2638 0.190373713316837 3956 44120435 SGTC_2647 atorvastatin 60.16 µM -0.876628990372404 0.217441288881615 no 2639 0.190344093768567 3918 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1658 st012944 20 µM -0.877262291125841 0.217277269337508 no 2640 0.190172094526925 3838 24207260 SGTC_2207 7258803 200 µM -0.878531057749264 0.216948884567359 no 2641 0.189827795442594 3907 3666799 SGTC_2949 9072542 2.23 µM -0.879796838606728 0.216621558615785 no 2642 0.189484688797632 4014 16457352 SGTC_1397 3532-0190 20.1 µM -0.879976446339914 0.216575135917282 no 2643 0.189436034680752 3861 5322280 SGTC_3129 9127257 49.47 µM -0.880570382285983 0.216421663978162 no 2644 0.189275197540762 3938 837894 SGTC_562 3772-2733 112 µM -0.880935457365682 0.216327360501452 no 2645 0.189176377379737 3954 2876874 YIL048W NEO1 SGTC_3093 9117344 49.47 µM -0.884795868345931 0.2153316244871 no 2646 0.188133369125529 3984 24824913 SGTC_2805 7950783 58.44 µM -0.886395415859605 0.214919825334979 no 2647 0.18770224429101 3981 1178958 YDL195W SEC31 SGTC_163 TUB2.036 7.546 µM -0.887958632974496 0.214517821637504 no 2648 0.187281501735875 3945 15992207 YJR013W GPI14 SGTC_1374 2889-5571 141 µM -0.888017369125839 0.214502725320258 no 2649 0.187265704175441 3990 2853281 SGTC_2129 girgensonine 121.053 µM -0.888326966530822 0.214423163058989 no 2650 0.187182449080628 3980 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1357 1503-1303 39.5 µM -0.890892265761819 0.213764577051986 no 2651 0.186493484966897 3924 292895 SGTC_3073 9114972 49.47 µM -0.891067826290394 0.213719548733946 no 2652 0.186446392049266 3929 41905075 SGTC_2608 thymoquinone 42.66 µM -0.893350149504198 0.213134674237148 no 2653 0.185834844848849 3955 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_3136 9095672 49.47 µM -0.893955977924356 0.212979579904656 no 2654 0.18567272264826 3692 17217380 SGTC_2412 st077135 33.4 µM -0.894159373282696 0.212927524704736 no 2655 0.185618312887375 4057 13258915 SGTC_1407 3909-7909 12.3 µM -0.894612464995746 0.212811591135316 no 2656 0.185497143078494 3936 4411780 SGTC_2802 7925815 54.55 µM -0.894721148383786 0.212783787558941 no 2657 0.185468085303835 3936 1262923 SGTC_839 0122-0028 230 µM -0.895428685044956 0.21260283612498 no 2658 0.185278986177513 3946 759448 SGTC_2906 7926292 26.41 µM -0.896378996756565 0.212359936807912 no 2659 0.185025190465104 3971 2966319 SGTC_19 0279-0214 38.434 µM -0.896572431156829 0.212310514918951 no 2660 0.184973557230227 4012 3566274 YBR002C RER2 SGTC_1209 2323-2347 50.3 µM -0.897492299667284 0.212075583375928 no 2661 0.184728140264711 3955 5412760 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.899185437767888 0.211643558822148 no 2662 0.184276947785081 3963 688751 SGTC_1702 st027038 51 µM -0.900732348287321 0.211249296704817 no 2663 0.183865322492775 3997 5521182 SGTC_2447 5741742 33.78 µM -0.900767510514146 0.211240339889189 no 2664 0.183855972658168 4025 1776504 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.901571358363781 0.211035637755519 no 2665 0.183642305750438 4014 94937 An inhibitor of serotonin biosynthesis. SGTC_859 0439-0102 54.6 µM -0.902244876644255 0.210864213978503 no 2666 0.183463400296673 3951 610143 SGTC_946 3434-1334 87.4 µM -0.903563038720712 0.210528951946902 no 2667 0.183113573783818 3959 4047976 SGTC_501 nsc-95397 161 µM -0.903607118402195 0.210517746105868 no 2668 0.183101882689195 4029 262093 SGTC_2084 5306078 60.6385 µM -0.905480501982782 0.21004182225869 no 2669 0.182605442424142 3921 679340 SGTC_687 k029-0044 34.9 µM -0.906941328773127 0.209671145482639 no 2670 0.182218912152095 4064 5829338 SGTC_2336 9001819 198.65 µM -0.909070021764687 0.209131690578412 no 2671 0.181656582789949 4019 2989602 SGTC_1117 retinoic acid 1.10837 µM -0.909771176579269 0.208954182499958 no 2672 0.181471599173579 4014 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_3071 9117417 49.47 µM -0.910627827325619 0.208737428743516 no 2673 0.181245751626795 3920 45595590 YGL055W OLE1 SGTC_1398 3558-0053 112 µM -0.912178651233043 0.208345369318026 no 2674 0.180837340169742 3883 4532369 SGTC_2919 7978188 46.38 µM -0.913181991910467 0.208091949172197 no 2675 0.180573416702624 3976 2980291 SGTC_2692 st077426 47.7 µM -0.914253657964618 0.207821472692836 no 2676 0.180291787561358 4008 25238571 SGTC_1219 1469-0211 33.1 µM -0.915217768323487 0.20757831957458 no 2677 0.180038659250873 4002 6822282 SGTC_3021 9087658 49.47 µM -0.915522329992511 0.207501542660241 no 2678 0.179958742626578 3945 25237042 SGTC_2515 chrysin 20.77 µM -0.919843330553667 0.206414071547621 no 2679 0.17882731814464 4020 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2983 9022671 12.99 µM -0.920463884500424 0.206258173811414 no 2680 0.178665198813626 4011 6405161 SGTC_1750 st081859 2.357 µM -0.920842116709274 0.206163187233233 no 2681 0.17856643129338 3960 5291695 SGTC_844 0330-0132 15.3 µM -0.923100631418232 0.205596539718238 no 2682 0.177977382809759 4033 2828079 SGTC_2310 7668677 200 µM -0.924009126331154 0.205368864910555 no 2683 0.177740782101983 4014 2197143 SGTC_161 4065-0411 162.148 µM -0.926789181455022 0.20467309564888 no 2684 0.177018001545022 4027 1906281 YLR208W SEC13 SGTC_1673 st016611 27.3 µM -0.927740659587551 0.204435290023158 no 2685 0.17677105594996 4046 5226799 SGTC_2406 ethylparaben 405.7 µM -0.929096720084434 0.204096650351245 no 2686 0.176419482058696 4052 8434 A possible steroid mimic. SGTC_700 3453-2283 142 µM -0.931412688570976 0.203519072703327 no 2687 0.175820064911944 4073 565664 SGTC_874 0599-0792 117 µM -0.93443458687815 0.202766911498476 no 2688 0.175039881799262 4028 765305 SGTC_1173 0443-0020 122 µM -0.934767175308061 0.202684230639163 no 2689 0.174954149654321 4006 5331295 SGTC_3142 9086498 49.47 µM -0.935567785998153 0.202485282966545 no 2690 0.174747883539613 3938 25236367 SGTC_1875 nocodazole 6 µM -0.936133948493484 0.202344664974638 no 2691 0.174602112936647 4012 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2870 9038528 12.99 µM -0.936956342910965 0.20214051062757 no 2692 0.17439050754819 4074 6463316 SGTC_2355 9061122 103.12 µM -0.937521074374943 0.202000390922185 no 2693 0.17424529426215 4035 5302957 SGTC_3155 9099265 49.47 µM -0.93929345456733 0.201561010232981 no 2694 0.17379004913365 4054 25236499 SGTC_2641 levomentholum 100 µM -0.943724303177489 0.200465091654457 no 2695 0.172655275697853 4003 16666 SGTC_2998 9066762 71.4286 µM -0.943774473822909 0.200452703058604 no 2696 0.172642453727726 4063 4945196 SGTC_2148 5546263 113.568 µM -0.948211588069785 0.199358869696553 no 2697 0.17151087451098 4012 792097 SGTC_1009 4106-0057 9.87 µM -0.948247083683213 0.199350133865416 no 2698 0.171501841360892 4015 2928005 SGTC_3277 9138724 49.47 µM -0.948467695965915 0.199295844109246 no 2699 0.17144570535735 3968 15943418 SGTC_1183 1254-0324 198 µM -0.948643411312925 0.199252609263863 no 2700 0.171401002027743 4103 5799357 SGTC_2965 9082772 38.63 µM -0.949026186819552 0.199158446724001 no 2701 0.17130364680291 4042 16459634 SGTC_230 MPP+ 141.667 µM -0.953018491147935 0.198177940942958 no 2702 0.170290350939852 4023 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_630 4356-0227 183 µM -0.95387378362488 0.197968261670443 no 2703 0.170073767649952 4006 779312 SGTC_3157 9099274 49.47 µM -0.956024041106296 0.197441707389575 no 2704 0.169530044278064 4054 17217662 SGTC_2701 st077767 14.721 µM -0.956416189478028 0.197345769626247 no 2705 0.16943100433052 4008 5721188 SGTC_769 0302-0231 76 µM -0.957519991639017 0.197075879599274 no 2706 0.169152430393228 3978 571869 YER009W NTF2 SGTC_381 3461-2219 42.7 µM -0.957999358255983 0.196958739548335 no 2707 0.169031541080866 4049 2883159 SGTC_2772 vinpocetine 57.06 µM -0.960005889993585 0.196468872602656 no 2708 0.168526125287473 4064 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1064 honokiol 6.76 µM -0.961179942251533 0.196182586703182 no 2709 0.168230849852315 4054 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1190 1486-1332 13 µM -0.961748629634456 0.196044006539391 no 2710 0.168087944070105 4046 4150046 SGTC_3345 9148410 3.559 µM -0.968006323975699 0.194523029569699 no 2711 0.166520605687924 4026 4903596 SGTC_1451 4152-0210 104 µM -0.969441923620081 0.194175112359306 no 2712 0.16616237177573 4081 659563 SGTC_2288 7946289 167.31 µM -0.969937689508173 0.194055051721166 no 2713 0.166038776030443 4123 1246052 SGTC_3313 9133968 57.047 µM -0.971611968938601 0.193649922448898 no 2714 0.1656218129272 4050 1494643 SGTC_2358 9037157 4 µM -0.972342458157266 0.193473326000339 no 2715 0.165440104003589 4050 2388925 SGTC_2648 atorvastatin 78.68 µM -0.97235608167911 0.19347003343471 no 2716 0.165436716383075 4073 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1192 1488-0095 21.4 µM -0.973366024952301 0.193226043109382 no 2717 0.165185709190828 4112 915875 SGTC_3084 9116877 49.47 µM -0.973977949164346 0.193078300884366 no 2718 0.165033744023069 3976 27241325 SGTC_250 brefeldin a 552.239 µM -0.974151292469717 0.193036461630647 no 2719 0.164990712429666 3922 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2819 7996655 46.38 µM -0.97607967454406 0.192571388389856 no 2720 0.164512491422861 4024 6456960 SGTC_1208 2323-2347 50.3 µM -0.976275842295146 0.192524116479686 no 2721 0.16446389401833 4081 5412760 SGTC_2108 5365811 200 µM -0.976708914583922 0.192419781151381 no 2722 0.164356640276442 4085 780283 SGTC_319 1348-1596 45.5 µM -0.980327904751202 0.191549250002647 no 2723 0.163462142326444 4169 5380505 SGTC_1751 st044839 27.194 µM -0.980729834056828 0.191452716868518 no 2724 0.1633629937744 4064 5291326 SGTC_1895 st058434 18.3 µM -0.980811855530637 0.1914330210722 no 2725 0.163342765389108 4091 5393175 SGTC_1972 st070201 17.4 µM -0.981392658802667 0.191293588451881 no 2726 0.163199572478852 4062 2829099 SGTC_2928 9011484 9.79 µM -0.982057043463988 0.191134166918339 no 2727 0.163035873226788 4092 2994751 SGTC_2277 7947813 106.88 µM -0.982407745572828 0.191050047522428 no 2728 0.162949505990129 4142 1246798 SGTC_2891 9063876 19.48 µM -0.984138638230246 0.190635208317375 no 2729 0.162523675686312 4058 6472478 SGTC_1355 1499-0035 1.68 µM -0.984487068697847 0.190551767662133 no 2730 0.162438043239651 4061 1548538 SGTC_2420 aureobasidin a 50 nM -0.984854398248482 0.190463825417792 no 2731 0.162347797838133 4200 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1022 4477-0945 21.3 µM -0.986680200127096 0.190027080708392 no 2732 0.161899719789091 4029 4648966 SGTC_1626 st003712 1.76 µM -0.987841408301405 0.189749632011048 no 2733 0.161615162161849 4114 24207035 SGTC_3315 9136395 68.55 µM -0.987987479076062 0.189714748815364 no 2734 0.161579390169345 4077 16876844 SGTC_1998 st075797 76.8 µM -0.9888117189227 0.189517985836295 no 2735 0.161377634754521 4044 24208315 SGTC_3329 9141233 27.5565 µM -0.990271602124764 0.189169790035999 no 2736 0.161020691496187 4054 4909101 YNL103W MET4 SGTC_2670 beta-carotene 100 µM -0.990299247011666 0.189163200274587 no 2737 0.161013937261667 4003 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1379 2144-0755 36.5 µM -0.991374513808071 0.188906996681197 no 2738 0.160751370154267 4146 5392327 SGTC_2002 4023503 131 µM -0.992076765727272 0.188739786732431 no 2739 0.16058003976505 4082 4736863 YCR052W RSC6 SGTC_2184 6075246 200 µM -0.992433715780206 0.188654829989425 no 2740 0.160492999389346 4085 2267320 SGTC_2605 digitonin 300 nM -0.994260437328958 0.188220425926358 no 2741 0.160048045617418 4128 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2839 9003951 25.97 µM -0.994541592365827 0.188153620619961 no 2742 0.159979633427262 4141 2990634 SGTC_2899 9053889 58.44 µM -0.997222156152391 0.187517426349538 no 2743 0.159328344392101 4053 6470052 SGTC_1987 st072290 61.9 µM -0.999406529084862 0.186999980281114 no 2744 0.158798899130751 4107 54697379 SGTC_468 gf-109203x 121 µM -0.999689449700478 0.18693302519256 no 2745 0.15873040968044 4060 2396 A protein kinase C inhibitor. SGTC_513 4245-1575 41.7 µM -1.00005199938693 0.186847247029091 no 2746 0.158642671929263 3993 719745 SGTC_1769 st044406 64.4 µM -1.0016281778368 0.186474611183088 no 2747 0.158261603288225 4061 670903 SGTC_1620 st003704 16.5 µM -1.00186970770721 0.186417550042211 no 2748 0.158203262344123 4034 2834414 SGTC_33 0986-0033 35.816 µM -1.00229391700505 0.186317357290134 no 2749 0.158100829802858 4037 2848082 SGTC_1430 4049-0248 69.1 µM -1.00253390753541 0.186260689408972 no 2750 0.15804289929761 4100 22774488 SGTC_274 sirtinol 40.1 µM -1.00319791536688 0.186103955896246 no 2751 0.157882689307566 4159 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1271 0832-2808 169 µM -1.00352543749953 0.186026677142927 no 2752 0.157803704954266 4123 3663794 SGTC_415 dibenzyl ketone 100 µM -1.00393447042715 0.185930193882289 no 2753 0.157705100127143 4078 7593 SGTC_1643 st009866 20.2 µM -1.00607680964096 0.185425362929186 no 2754 0.157189311573333 4040 3156273 YOR207C RET1 SGTC_3322 9139058 2.11 µM -1.00946914770991 0.184627718650121 no 2755 0.156374845360975 4182 4908926 YPR165W RHO1 SGTC_1066 ketoconazole 628 nM -1.01145738734452 0.184161214839162 no 2756 0.155898783225108 4162 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_766 1391-0721 126 µM -1.01467158970763 0.18340861477798 no 2757 0.155131200578543 4140 1020919 YIL115C NUP159 SGTC_1068 loratadine 26.9 µM -1.01467483296385 0.183407856344654 no 2758 0.155130427319804 4140 3957 A H1 histamine antagonist. SGTC_3290 9121031 71.43 µM -1.01730245292614 0.182794031742644 no 2759 0.154504785038019 4126 17014854 SGTC_2999 9069765 71.4286 µM -1.01935831587628 0.182314667594429 no 2760 0.154016443978953 4085 2097066 SGTC_2717 st081029 62.2815 µM -1.0198970178329 0.18218918882952 no 2761 0.153888652017623 4080 5292846 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.02011750793525 0.1821378460846 no 2762 0.153836367156584 4153 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1798 st045719 60.953 µM -1.02053899799925 0.18203972419074 no 2763 0.153736451859349 3995 3980186 SGTC_2814 7977482 42.97 µM -1.02237645844788 0.181612353928939 no 2764 0.153301379120036 4175 6456762 SGTC_959 1222-0044 107 µM -1.02289238072721 0.181492469864016 no 2765 0.153179366190133 4119 6083612 SGTC_2488 5268135 45.7 µM -1.02405947445739 0.181221456918136 no 2766 0.152903592124259 4170 1270356 YLR208W SEC13 SGTC_2398 5228213 48.84 µM -1.02410211571134 0.18121155991724 no 2767 0.152893522605493 4136 80771 YMR134W ERG29 SGTC_2616 abietic acid 100 µM -1.02479735629238 0.181050242893744 no 2768 0.152729407050647 4154 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_3118 9124250 49.47 µM -1.02734287346848 0.180460373378246 no 2769 0.152129520436051 4049 1504786 SGTC_2041 5107442 45.335 µM -1.02739023951024 0.180449408742147 no 2770 0.152118372816304 4167 793005 SGTC_3087 9117406 49.47 µM -1.02926752736467 0.180015177052614 no 2771 0.151676989051243 4141 42546093 SGTC_603 3794-0023 45.9 µM -1.02968571437341 0.179918536484332 no 2772 0.151578781890511 4167 3802260 SGTC_1615 st002656 86.5 µM -1.02979144784417 0.17989410726002 no 2773 0.151553958107278 4121 1584458 SGTC_511 blebbistatin 171 µM -1.03047048019507 0.179737269662442 no 2774 0.151394601367121 4183 3476986 A myosin inhibitor. SGTC_605 1315-0399 119 µM -1.03140165645495 0.179522333556168 no 2775 0.15117625220052 4194 24020461 SGTC_2751 anetholtrithion 17.25 µM -1.03181450693772 0.17942709023395 no 2776 0.151079511002584 4130 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2659 sanguinarine 24.21 µM -1.03228361304127 0.179318907477408 no 2777 0.15096963771039 4072 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1560 lithocholic acid 53.1 µM -1.03272601863199 0.179216919839972 no 2778 0.150866066908263 4022 9903 A bile acid which acts as a detergent. SGTC_2046 4110841 106 µM -1.03470988420449 0.17876002859721 no 2779 0.150402209309339 4127 44119630 YMR134W ERG29 SGTC_38 0929-0051 58.268 µM -1.03814040121782 0.177971700514804 no 2780 0.149602347298375 4132 1379719 SGTC_1237 0330-0133 46.1 µM -1.03893016246869 0.17779052537376 no 2781 0.149418608644473 4077 X1237 YHR072W ERG7 SGTC_1371 2421-0008 32.7 µM -1.03961119809711 0.177634385886555 no 2782 0.149260286108769 4107 2827552 SGTC_973 1325-0077 65.9 µM -1.04010041988274 0.177522276544078 no 2783 0.14914662431111 4135 2835149 SGTC_1239 0337-0584 35.4 µM -1.04092563265185 0.177333273226146 no 2784 0.148955032132117 4206 914301 YML130C ERO1 SGTC_539 4859-0462 2.54 µM -1.0411953171207 0.177271533368412 no 2785 0.148892454327738 4174 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_39 0986-0283 58.349 µM -1.04236378623097 0.177004188280735 no 2786 0.148621524764522 4223 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2032 5185112 25.99 µM -1.04239986831391 0.176995936776964 no 2787 0.148613163765212 4013 5718189 SGTC_1132 3456-3614 2.5 µM -1.04293163018463 0.176874357930648 no 2788 0.148489979501516 4205 3125502 SGTC_2976 9009005 19.48 µM -1.04572194502958 0.176237262513872 no 2789 0.147844713915934 4182 2993148 SGTC_3303 9125618 40.5795 µM -1.04669203402816 0.176016108707992 no 2790 0.147620819461236 4154 22695467 SGTC_897 1000-0139 31.4 µM -1.04863586361377 0.175573497684559 no 2791 0.147172871563128 4094 6151020 SGTC_645 0845-0943 5.41 µM -1.0495236612621 0.175371580535739 no 2792 0.146968585529045 4144 1885106 SGTC_128 0906-2981 13.371 µM -1.04985632822657 0.175295958024352 no 2793 0.146892086441932 4133 6740226 SGTC_2739 tacrine 100.86 µM -1.05105824712494 0.175022907790557 no 2794 0.146615919413822 4197 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1830 st055982 50.3 µM -1.05188784782341 0.174834597771259 no 2795 0.146425503979081 4103 455313 An antimicrobial agent. SGTC_852 0418-0143 439 µM -1.0536856246601 0.174426964131437 no 2796 0.146013436295995 4157 5369229 SGTC_1215 3852-0577 11.2 µM -1.05386794826721 0.174385657242049 no 2797 0.14597168953454 4196 2884876 SGTC_1059 3448-6867 171 µM -1.05673014192655 0.173738018764761 no 2798 0.145317382252149 4082 3934407 SGTC_3013 9080133 71.4286 µM -1.05854491124471 0.17332817827138 no 2799 0.144903543439974 4240 17050193 SGTC_3327 9140648 26.9345 µM -1.06008327411345 0.172981242790983 no 2800 0.144553358167952 4177 8029710 SGTC_728 3030-5151 22.5 µM -1.06083951037371 0.172810856797859 no 2801 0.144381421512199 4213 3125388 SGTC_3201 9113999 49.47 µM -1.06142522803479 0.172678963521381 no 2802 0.144248348441309 4181 16649224 SGTC_1971 st069429 63.5 µM -1.06287361617441 0.172353087726917 no 2803 0.14391963467206 4129 1246522 YGL099W LSG1 SGTC_1726 st035556 14.5795 µM -1.06860492767009 0.171067439178306 no 2804 0.142623863598372 4252 5919439 SGTC_2439 5492030 7.2 µM -1.06884799448969 0.171013050329313 no 2805 0.142569084444041 4154 5722370 SGTC_2971 9092186 9.93 µM -1.06917524970809 0.170939840882972 no 2806 0.142495354508759 4174 25236400 SGTC_1030 k029-0042 36.7 µM -1.07134699091534 0.170454514245144 no 2807 0.142006719119075 4149 6080581 SGTC_2532 xanthone 78.9 µM -1.07156691468878 0.170405416359498 no 2808 0.141957300242495 4164 7020 An insecticide. SGTC_1744 st037937 38.9 µM -1.07288434714157 0.170111489817603 no 2809 0.141661504964781 4244 1016152 SGTC_3259 9138485 49.47 µM -1.07370356820236 0.169928880954708 no 2810 0.141477780809957 4167 17646153 SGTC_2456 5770359 74.46 µM -1.07495515732192 0.169650137641519 no 2811 0.141197402722252 4192 3118787 SGTC_1479 0549-0158 134 µM -1.07710198584951 0.169172697634246 no 2812 0.140717353002041 4215 5440202 SGTC_1421 4029-0249 71.4 µM -1.07777506762228 0.169023186659775 no 2813 0.140567074326484 4244 2894095 SGTC_727 3032-0951 202 µM -1.07859176238766 0.168841889072363 no 2814 0.140384877575234 4204 3652836 SGTC_3300 9124615 50.48 µM -1.08374085784903 0.167701722998715 no 2815 0.139239857214652 4239 24824903 SGTC_2255 7941087 197.44 µM -1.08403845493251 0.167635977885036 no 2816 0.13917387444932 4272 935561 SGTC_3105 9121040 49.47 µM -1.08606683280976 0.167188311127623 no 2817 0.138724712480708 4057 41448907 SGTC_2941 9056145 11.23 µM -1.08725067654919 0.166927391110017 no 2818 0.13846302010309 4109 2119517 SGTC_2226 7298446 200 µM -1.08859261693824 0.166631944249775 no 2819 0.13816678700946 4169 3283010 SGTC_1849 st056239 19.2 µM -1.0889204804658 0.166559811859407 no 2820 0.138094476931978 4188 5393181 SGTC_563 tetrahydrosecaminediol 614 µM -1.09031261578477 0.166253756354242 no 2821 0.13778772989657 4238 334274 A psychoactive constituent of the cannabis plant. SGTC_450 aminopyrene 156 nM -1.090364173525 0.166242428566155 no 2822 0.137776378453161 4114 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2193 5925765 200 µM -1.09190072205341 0.165905061211342 no 2823 0.13743837015666 4178 877370 SGTC_2382 9035899 200 µM -1.09352705541085 0.165548462923544 no 2824 0.137081228338433 4177 6462679 SGTC_351 caspofungin 25 nM -1.09356191093483 0.165540825750765 no 2825 0.137073581033185 4195 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_753 1322-0200 289 µM -1.09672288319248 0.164849174498692 no 2826 0.13638127503583 4265 5403907 SGTC_2551 apiole 73.87 µM -1.10090884854746 0.163936129631003 no 2827 0.135468165276915 4094 10659 A possible DNA adduct former. SGTC_3236 9132701 49.47 µM -1.10180219527927 0.163741698074727 no 2828 0.135273837896621 4192 24282524 SGTC_1691 st019933 84.6 µM -1.10337445551614 0.163399868769641 no 2829 0.134932292540113 4191 6176082 SGTC_2543 pimpinellin 60.67 µM -1.10502572504058 0.163041361266861 no 2830 0.134574221195985 4014 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1086 cerivastatin 2.18 µM -1.10507630947444 0.163030386946343 no 2831 0.134563262464996 4169 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1096 rimcazole 32.2 µM -1.10825137647394 0.162342515437546 no 2832 0.133876634133377 4117 18528119 A dopamine reuptake inhibitor. SGTC_1420 4'-methoxyflavone 42 µM -1.11072749821603 0.161807382014463 no 2833 0.133342831098987 4193 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_571 k831-0106 44.2 µM -1.11082335775788 0.161786688219767 no 2834 0.13332219515404 4065 4783639 SGTC_384 k007-0144 5.16 µM -1.11164661141821 0.161609038348265 no 2835 0.13314506155488 4140 6824886 SGTC_2890 9046729 58.44 µM -1.11208657429546 0.161514150935055 no 2836 0.133050464327947 4164 903329 SGTC_2093 5331342 194.4 µM -1.11272915687172 0.161375629528898 no 2837 0.132912384611602 4268 33839 SGTC_113 0099-0221 2.5 µM -1.11459277264658 0.160974328556723 no 2838 0.132512484428399 4169 89219 SGTC_2143 5623677 140.463 µM -1.11725639230247 0.160401890813073 no 2839 0.131942357537266 4176 5375313 SGTC_3246 9135460 32.98 µM -1.11850512478688 0.160133984597016 no 2840 0.131675659494828 4182 41446951 SGTC_3238 9133470 49.47 µM -1.11869338026427 0.160093621182397 no 2841 0.131635485122587 4204 3534688 SGTC_1759 st043059 70 µM -1.11873621409701 0.160084438209993 no 2842 0.13162634541545 4200 669426 SGTC_2443 5493264 126.67 µM -1.1195163869077 0.159917240376856 no 2843 0.131459951979154 4252 5340055 SGTC_1395 3486-0190 4.35 µM -1.12091884631822 0.159616968406727 no 2844 0.131161203972907 4210 6748079 SGTC_506 n9-isopropylolomoucine 153 µM -1.1230785147012 0.159155297135201 no 2845 0.130702075090563 4235 6610355 SGTC_361 000s-0510 1.45 µM -1.1257506255684 0.158585293114115 no 2846 0.130135544256145 4150 660 SGTC_2994 9053520 71.4286 µM -1.12691466425398 0.158337404156933 no 2847 0.129889281339701 4264 4647384 SGTC_477 mead ethanolamide 10 µM -1.13004770658107 0.157671467804772 no 2848 0.129228061423581 4144 16061185 SGTC_1716 st033144 30.6155 µM -1.13349486618604 0.156940894003764 no 2849 0.128503247944478 4250 674617 SGTC_1060 3448-7350 82 µM -1.13496606769405 0.156629774035966 no 2850 0.128194768005109 4176 570178 SGTC_2065 5221596 34.26 µM -1.13550328119319 0.156516268941059 no 2851 0.128082253946385 4207 788581 SGTC_1259 0671-0132 43 µM -1.13708813513087 0.156181728893998 no 2852 0.127750721706896 4160 X1259 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.13784374094297 0.156022397263687 no 2853 0.127592868280515 4215 688667 SGTC_717 1532-0246 73.2 µM -1.13924554168576 0.15572708886927 no 2854 0.127300377696466 4211 9561992 SGTC_1253 0550-0034 176 µM -1.13983521366288 0.15560297665264 no 2855 0.127177480064766 4259 5969915 SGTC_152 4469-0003 551.229 µM -1.14218750487089 0.155108523578245 no 2856 0.126688044318327 4198 697280 SGTC_2954 9074818 52.69 µM -1.14244063987356 0.155055376334339 no 2857 0.126635453386748 4257 16648742 SGTC_2158 5657123 3.6195 µM -1.14359996229846 0.154812123152586 no 2858 0.12639478866313 4202 2858827 SGTC_1813 st051246 8.6015 µM -1.15051489959153 0.153366445128561 no 2859 0.12496593052893 4185 5291959 SGTC_702 1488-0190 94 µM -1.15244330361357 0.152964881458791 no 2860 0.124569477541636 4267 949357 SGTC_2953 9074162 66.49 µM -1.15256715515523 0.15293911491934 no 2861 0.124544045473093 4236 16451992 SGTC_205 1486-1330 71.903 µM -1.15264477849194 0.152922967336175 no 2862 0.124528107901385 4282 4118834 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.15368354588272 0.152706986686832 no 2863 0.124314966078941 4260 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1790 st045711 43.5 µM -1.15422395109934 0.152594705616131 no 2864 0.124204182772033 4252 585119 SGTC_3133 9127736 49.47 µM -1.15566877185891 0.152294781367158 no 2865 0.123908333088947 4259 27243420 SGTC_1415 3966-0071 78.1 µM -1.15894739294326 0.151615638737509 no 2866 0.12323881456581 4183 2893185 SGTC_1636 st007707 68.9 µM -1.15920025493073 0.151563343954146 no 2867 0.12318728378891 4289 403051 SGTC_435 c-PAF 6.7 µM -1.16175672349355 0.151035310175635 no 2868 0.122667148724693 4225 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_467 ro 31-8220 72.8 µM -1.16467522179108 0.150433998073862 no 2869 0.122075241223967 4201 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_398 bronopol 33.3 µM -1.16682231970112 0.149992640935422 no 2870 0.121641065720806 4181 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_3305 9127027 53.8275 µM -1.16872398717921 0.149602456166787 no 2871 0.121257427163246 4192 41905295 SGTC_2820 7989630 71.43 µM -1.16975193225767 0.149391824311077 no 2872 0.121050406254066 4293 2984098 SGTC_1828 st055811 49 µM -1.17154736561 0.149024404769275 no 2873 0.120689415296412 4260 5877589 SGTC_1919 st067113 52.3 µM -1.17353409588657 0.148618542135798 no 2874 0.120290846096112 4284 1268243 SGTC_858 0438-0351 2.77 µM -1.1752377795339 0.148271091262118 no 2875 0.119949799748607 4232 2799119 SGTC_2076 5212012 200 µM -1.17680737082919 0.147951468626236 no 2876 0.119636199995739 4219 604802 SGTC_913 3487-1245 167 µM -1.17787981591706 0.147733347429264 no 2877 0.119422261415362 4215 4016153 SGTC_3160 9100216 49.47 µM -1.17862237853698 0.14758244621534 no 2878 0.119274288262849 4229 17191039 SGTC_2263 7948595 193.29 µM -1.17980928873847 0.147341460583427 no 2879 0.119038037159017 4274 2971371 SGTC_3139 9095020 49.47 µM -1.18134977973132 0.14702907874752 no 2880 0.118731899778077 4086 25236292 SGTC_1230 0170-0365 3.77 µM -1.18321891439724 0.146650651064598 no 2881 0.118361199358022 4323 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_185 k048-0037 25.491 µM -1.18335310166677 0.146623508486386 no 2882 0.118334617872596 4326 6827589 SGTC_2473 5854593 8.94 µM -1.18597551032088 0.146093740467045 no 2883 0.117815985480658 4169 2872951 SGTC_2219 9098279 200 µM -1.18822892677315 0.145639543110708 no 2884 0.117371615066155 4213 902349 SGTC_1521 st012942 49.4 µM -1.18905660496274 0.145472955410317 no 2885 0.117208696564637 4232 24207259 SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.19062621626962 0.145157390098203 no 2886 0.116900177539667 4269 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_797 k781-0471 270 µM -1.19289607362676 0.144701857902958 no 2887 0.116455038574826 4252 23738129 SGTC_2520 obtusaquinone 4.71 µM -1.19302670813615 0.144675670512303 no 2888 0.116429456639623 4321 5967872 SGTC_478 N-arachidonylglycine 10 µM -1.19379546852397 0.144521627139548 no 2889 0.116278992347259 4261 5283389 SGTC_1116 jasmonic acid  1.58368 µM -1.19693737928017 0.143893203543521 no 2890 0.115665481702773 4335 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1222 0366-0074 1.18 µM -1.19782201296055 0.143716598200644 no 2891 0.115493157767279 4301 286520 SGTC_2505 galangin 7.89 µM -1.19862906874407 0.143555607890165 no 2892 0.115336104968669 4173 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1456 k015-0012 13 µM -1.20183714498595 0.142916869504557 no 2893 0.114713315434595 4300 2989616 SGTC_2463 5473429 200 µM -1.20272614326841 0.142740207448367 no 2894 0.114541156823557 4278 5399405 SGTC_2201 6605497 169.863 µM -1.20309008446238 0.142667927531582 no 2895 0.11447073101438 4222 670741 SGTC_3034 9090421 49.47 µM -1.20362835350205 0.142561070905105 no 2896 0.114366627755944 4192 17173761 SGTC_2237 6667747 47.222 µM -1.20402087243421 0.142483182576422 no 2897 0.114290755628383 4300 729940 YDL015C TSC13 SGTC_547 1120-0019 610 nM -1.20407498372671 0.142472447420603 no 2898 0.11428029897296 4234 3676939 SGTC_1698 5-fluorocytosine 1.055 µM -1.20797161149225 0.141700832206377 no 2899 0.113529091076442 4300 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1461 k072-0203 53.8 µM -1.20882593004207 0.141532038002278 no 2900 0.113364863714737 4199 5418714 SGTC_1346 1488-2224 62.4 µM -1.21026874809112 0.141247278926494 no 2901 0.113087892776956 4300 3722427 SGTC_1945 st075991 56.6 µM -1.21650585370986 0.140020774879125 no 2902 0.11189614125404 4283 1084980 SGTC_211 3455-0679 143.504 µM -1.21752389538613 0.139821269783613 no 2903 0.11170247525502 4325 748649 SGTC_358 0075-0058 9.45 µM -1.21795206179475 0.139737419986355 no 2904 0.111621095176826 4210 1069125 SGTC_286 k060-0067 22.9 µM -1.21848904290817 0.139632308835642 no 2905 0.111519093042393 4331 5985051 SGTC_3101 9120531 49.47 µM -1.2301249894167 0.137367836205534 no 2906 0.109325151778869 4305 24824904 SGTC_2249 haloperidol 116.36 µM -1.23061633438962 0.137272770511888 no 2907 0.109233196536495 4274 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1926 methyl fluorone black 53.6 µM -1.23061912000902 0.137272231676853 no 2908 0.109232675366121 3961 72721 Reacts with homocysteine. SGTC_10 0279-0212 42.575 µM -1.23099714635322 0.13719912172033 no 2909 0.109161965788913 4292 39851 YBR002C RER2 SGTC_9 0092-0002 10.449 µM -1.23134676582932 0.137131529305108 no 2910 0.109096598979481 4313 759368 SGTC_164 4100-3994 89.624 µM -1.23242418756815 0.136923372968344 no 2911 0.108895335123175 4316 4615967 SGTC_2063 5246145 200 µM -1.23451272761947 0.136520485289509 no 2912 0.108505953497937 4358 711240 SGTC_247 mechlorethamine 29.705 µM -1.23503671194393 0.136419533983099 no 2913 0.10840842067789 4246 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_3086 9117350 49.47 µM -1.23554781776529 0.136321113070218 no 2914 0.108313345812472 4252 2679265 SGTC_3042 9091578 49.47 µM -1.23618045635337 0.136199356540839 no 2915 0.108195746792583 4311 25236497 SGTC_1496 4469-0713 57.4 µM -1.23757592754102 0.135931049757782 no 2916 0.107936672442858 4298 746691 SGTC_183 3914-0051 30.55 µM -1.23807588567456 0.135835011085654 no 2917 0.107843962164248 4337 1596232 SGTC_1909 st060837 51.5 µM -1.23821008118074 0.135809240922637 no 2918 0.107819087241399 4281 678937 SGTC_3119 9125183 49.47 µM -1.23879266592524 0.135697403390253 no 2919 0.10771114532113 4150 22695334 SGTC_652 0437-0092 114 µM -1.23920652545608 0.135617994007079 no 2920 0.107634512298376 4254 3091274 SGTC_1715 st032160 10.2275 µM -1.24196535055273 0.13508945735703 no 2921 0.107124673251565 4247 5289825 SGTC_2704 st078022 71.1 µM -1.2445450107668 0.134596524667362 no 2922 0.106649522148459 4349 54697681 SGTC_2744 captopril 92.04 µM -1.24972352006308 0.133610722985602 no 2923 0.105700281201015 4386 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2050 5263056 171 µM -1.25029154106418 0.133502895174115 no 2924 0.105596533660502 4313 763468 YGL055W OLE1 SGTC_1700 st030840 7.9285 µM -1.25071559516436 0.13342243572509 no 2925 0.105519129314731 4362 5499307 SGTC_2638 epoxomicin 18 µM -1.25164575420674 0.133246065455242 no 2926 0.105349487281235 4297 9915668 A protesome inhibitor. SGTC_1969 st069479 40.1 µM -1.25200517548535 0.133177957489238 no 2927 0.105283989049153 4338 3895485 SGTC_2257 7960413 200 µM -1.25712055381211 0.132211223462129 no 2928 0.104354992762471 4359 2974689 YIL048W NEO1 SGTC_444 curcumin 90.4 µM -1.25746268514268 0.132146738536503 no 2929 0.104293071412413 4260 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2524 avocatin b 10.57 µM -1.25837822539348 0.13197428414798 no 2930 0.104127501443178 4325 6710748 SGTC_3164 9100705 49.47 µM -1.26214898987115 0.131265646175204 no 2931 0.103447589921819 4332 17174235 SGTC_310 1273-0058 1.06 µM -1.26463240184835 0.130800377459339 no 2932 0.103001566134374 4120 2734232 SGTC_3319 9138450 16.7555 µM -1.26818451814513 0.130136869562318 no 2933 0.102366032232973 4271 2029690 SGTC_490 phenamil 164 µM -1.26853193144694 0.130072100706506 no 2934 0.102304027524868 4326 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2629 bisabolol 100 µM -1.26981610235304 0.129832884194342 no 2935 0.10207507177657 4373 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2570 licareol 100 µM -1.27141326737272 0.12953578812694 no 2936 0.101790832568001 4323 443158 SGTC_2519 cryptotanshinone 88.04 µM -1.27230697258003 0.12936975153967 no 2937 0.101632036088367 4318 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_3125 9127534 49.47 µM -1.27276259996306 0.129285159814082 no 2938 0.101551148174737 4237 1639235 SGTC_2164 5685496 200 µM -1.27635388228754 0.128619744703408 no 2939 0.100915225447098 4267 759046 SGTC_2021 4019055 173 µM -1.27741088935862 0.128424349354823 no 2940 0.10072861115864 4153 44827708 YER133W GLC7 SGTC_182 3448-4371 550.524 µM -1.28132853053757 0.127701942918739 no 2941 0.100039147865939 4234 3491403 SGTC_2074 5212007 75.395 µM -1.28163757360749 0.127645076337083 no 2942 0.0999849065602911 4262 758611 SGTC_2045 5106652 78.05 µM -1.28375098815901 0.127256661719903 no 2943 0.099614548796687 4320 673349 SGTC_3215 9129942 49.47 µM -1.28480211932321 0.127063785694994 no 2944 0.0994307207988655 4346 17682944 SGTC_2884 9058502 51.95 µM -1.28559355732434 0.126918696067614 no 2945 0.0992924731978991 4373 6471554 SGTC_1435 4092-0789 56.7 µM -1.28944262167266 0.126214714427125 no 2946 0.0986221259699954 4346 2248285 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.28978133660157 0.126152895085257 no 2947 0.0985632948611195 4369 551469 SGTC_745 0469-0705 296 µM -1.28996153918321 0.126120014659472 no 2948 0.0985320060996002 4399 3486736 SGTC_1188 1403-0014 4.57 µM -1.29047459435476 0.126026433445496 no 2949 0.0984429636221631 4363 9614867 SGTC_1113 artemisinin 1.17947 µM -1.29109330795685 0.12591364455343 no 2950 0.0983356621509907 4399 2240 An anti-malaria and mitochondrial poison. SGTC_3346 9158254 43.5805 µM -1.29132416478237 0.125871578361727 no 2951 0.0982956473590906 4361 17639500 SGTC_2886 9058944 51.95 µM -1.29145965172117 0.125846894812741 no 2952 0.0982721687400242 4267 4949929 SGTC_1996 st072960 66.8 µM -1.2917530264426 0.125793458210125 no 2953 0.0982213437224018 4381 1719405 SGTC_503 tyrphostin 8 294 µM -1.29247609242347 0.125661823272158 no 2954 0.0980961600620376 4387 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2252 omeprazole 400 µM -1.29305552214401 0.125556406856635 no 2955 0.0979959283987763 4373 4594 A proton pump inhibitor. SGTC_2840 9008771 71.43 µM -1.29311060110008 0.125546389482051 no 2956 0.0979864045668098 4297 2992978 SGTC_1974 st069448 26.9 µM -1.29396477135589 0.125391110369769 no 2957 0.0978387947896177 4346 6323587 YNR016C ACC1 SGTC_3270 9137563 49.47 µM -1.29410633942509 0.125365387749205 no 2958 0.0978143460634792 4355 17015724 SGTC_2955 9076254 12.21 µM -1.29625209147047 0.124975960095407 no 2959 0.0974443240978186 4270 16459619 SGTC_314 1671-0008 2.74 µM -1.29676148098358 0.12488363640067 no 2960 0.0973566339523766 4248 3913060 SGTC_3107 9121808 49.47 µM -1.29732166417335 0.124782161693876 no 2961 0.0972602666545361 4312 662681 SGTC_264 promethazine 12.5 mM -1.30219742250444 0.123901372624737 no 2962 0.0964244530385633 4240 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1808 st050063 61.5 µM -1.30311566646315 0.123735983113762 no 2963 0.0962676379140881 4343 4011993 SGTC_1313 1220-0047 237 µM -1.30524106635424 0.123353759816442 no 2964 0.0959053873129303 4354 3528706 SGTC_1043 0916-0009 19.3 µM -1.30564562063915 0.123281100226237 no 2965 0.0958365492907647 4390 3101130 SGTC_1263 0774-1208 64.8 µM -1.32238118999081 0.12030157131929 no 2966 0.0930206246203718 4403 906585 SGTC_2667 digitoxin 100 µM -1.32291014816305 0.120208232153338 no 2967 0.092932630055319 4324 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2096 5468907 200 µM -1.3260311659465 0.119658540750933 no 2968 0.0924146871822841 4371 759785 SGTC_73 0327-0325 16.231 µM -1.3277814794214 0.119351042639488 no 2969 0.0921251535254666 4211 53298 SGTC_3193 9111931 49.47 µM -1.32999176508312 0.118963533075524 no 2970 0.091760492275573 4376 17087244 SGTC_3100 9120536 49.47 µM -1.33324431687287 0.118394909405632 no 2971 0.0912258201886134 4275 16421196 SGTC_610 4215-0184 155 µM -1.33830518969264 0.117513973139738 no 2972 0.0903984853889447 4398 5605015 SGTC_198 3454-2873 16.191 µM -1.33852545196185 0.117475738180942 no 2973 0.0903626045775174 4405 710957 SGTC_1689 st020265 53.493 µM -1.34020137633725 0.117185105738074 no 2974 0.0900899421392952 4395 5758320 YPR016C TIF6 SGTC_1866 st057638 64 µM -1.34376322410201 0.116569116156918 no 2975 0.0895124826062107 4387 688802 SGTC_304 1310-0298 97 µM -1.34557298327703 0.116257015865303 no 2976 0.0892201347196457 4159 1550234 SGTC_2121 5257820 149.641 µM -1.34585075329347 0.116209165838988 no 2977 0.0891753268069955 4431 791256 SGTC_1400 3771-8998 51.5 µM -1.34858661301739 0.11573861985341 no 2978 0.0887348914709949 4333 670767 SGTC_3354 9151612 71.43 µM -1.34871816479257 0.115716028148806 no 2979 0.0887137543594598 4398 27261949 SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.35033169389052 0.115439187675396 no 2980 0.0884548051774976 4409 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1825 st052143 62.6 µM -1.35034464334694 0.115436967784122 no 2981 0.0884527292486436 4445 674173 SGTC_12 0849-0099 9.267 µM -1.35393562185842 0.114822545928755 no 2982 0.0878784587984458 4333 6071388 SGTC_2246 7293507 91.5585 µM -1.35394422773761 0.114821076249639 no 2983 0.087877085891427 4465 887656 SGTC_1256 0570-0116 285 µM -1.35496920458562 0.114646130329131 no 2984 0.087713684400079 4399 410638 SGTC_321 4534-3890 65.3 µM -1.35825553485327 0.114086489602696 no 2985 0.0871913071202129 4399 699746 SGTC_2921 7974240 10.71 µM -1.35940550778705 0.113891117047547 no 2986 0.0870090633831369 4483 2979074 YDR527W RBA50 SGTC_2139 5578692 56.4705 µM -1.35964083549353 0.113851165879244 no 2987 0.0869718045562543 4386 650991 YMR113W FOL3 SGTC_465 cgp-37157 41 µM -1.36084883663608 0.11364624287577 no 2988 0.0867807324577707 4451 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1835 st008666 49.2 µM -1.36201330949781 0.113448952961619 no 2989 0.0865968424093514 4352 690455 SGTC_2828 7998861 71.43 µM -1.36746522394108 0.112528515342451 no 2990 0.0857397652044852 4399 2988188 SGTC_466 geldanamycin 89.2 µM -1.37387435622387 0.111453308654388 no 2991 0.0847403460092229 4431 5288382 HSP90 inhibitor. SGTC_996 3970-0799 1.8 µM -1.37610366457718 0.111081045225938 no 2992 0.0843947705854157 4400 6615648 YGL040C HEM2 SGTC_535 2293-4129 48.2 µM -1.38097773833222 0.110270246465069 no 2993 0.0836429027996675 4427 396118 YIL048W NEO1 SGTC_2669 eugenol 100 µM -1.38129406477277 0.110217772833463 no 2994 0.0835942811936014 4440 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2700 st077718 96.8 µM -1.38232985122535 0.110046077327188 no 2995 0.0834352221242578 4395 904970 SGTC_2927 9011802 47.9 µM -1.38647898561285 0.109360226671417 no 2996 0.0828003463570684 4396 43912568 SGTC_2909 7941780 10.49 µM -1.38822871491879 0.109071919288245 no 2997 0.0825337055116929 4388 1243215 SGTC_1167 k781-0610 148 µM -1.39489013162604 0.107979299805429 no 2998 0.081524486713244 4458 4525169 SGTC_1506 4226-2149 212 µM -1.3953132061371 0.107910173374277 no 2999 0.0814607057060458 4432 991114 SGTC_2852 9023854 51.95 µM -1.39730563284885 0.107585057871014 no 3000 0.081160841341474 4450 19798528 SGTC_779 1360-0071 233 µM -1.39748625295332 0.107555620000096 no 3001 0.0811336988700402 4459 7566 SGTC_383 2324-0395 7.37 µM -1.39795619229328 0.107479055428104 no 3002 0.0810631113901608 4419 3146421 SGTC_2025 5147754 141 µM -1.40352839855708 0.106574200125354 no 3003 0.0802296648388865 4401 315777 YLR208W SEC13 SGTC_690 glyoxal 20.3 µM -1.40379324134895 0.106531330340904 no 3004 0.0801902135770451 4236 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2935 9038016 29.96 µM -1.40461348951644 0.106398636743619 no 3005 0.0800681215737314 4388 6463195 SGTC_2335 9018011 154.17 µM -1.40594704602031 0.106183158791081 no 3006 0.0798699248802795 4413 6458208 SGTC_3219 9131112 49.47 µM -1.40815790990523 0.105826619086384 no 3007 0.0795421582229084 4300 17612988 YMR079W SEC14 SGTC_2753 fluvastatin 17.09 µM -1.40817969659866 0.105823109919514 no 3008 0.0795389333576529 4432 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2421 5690543 90.72 µM -1.4108704302582 0.1053903618391 no 3009 0.0791414112761302 4442 3397993 SGTC_1941 st076221 61.8 µM -1.41492878595599 0.10474008417184 no 3010 0.0785446884849183 4316 2828568 SGTC_2415 st077333 57.7 µM -1.41975920772917 0.103969890496414 no 3011 0.0778388972366722 4460 2766255 SGTC_526 4469-0568 170 µM -1.42242363551064 0.103546818494186 no 3012 0.0774516528625361 4400 2901964 SGTC_634 1611-4317 11.2 µM -1.42705293158608 0.102814727844786 no 3013 0.0767823190566952 4481 2843522 SGTC_916 4466-0038 42 nM -1.42865471667911 0.102562294692368 no 3014 0.0765517495704529 4511 5722064 YGL116W CDC20 SGTC_23 0213-0011 39.996 µM -1.42910709743632 0.102491083455807 no 3015 0.0764867269406023 4448 627608 SGTC_356 1634-0012 32.5 µM -1.43089522461422 0.102209958397172 no 3016 0.0762301229439403 4441 735457 SGTC_1611 st001856 99.4 µM -1.43723202369528 0.101218218586033 no 3017 0.0753260382548889 4436 647478 SGTC_2483 5729050 27.16 µM -1.4377365457034 0.101139560856058 no 3018 0.0752544098002482 4449 2865180 SGTC_2650 prasterone 100 µM -1.43825221135441 0.101059211815149 no 3019 0.0751812529218407 4462 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1040 k898-0338 155 µM -1.44081233977334 0.100660991276187 no 3020 0.0748188531758409 4445 20969351 SGTC_11 0438-0307 1.3 µM -1.44180966384756 0.100506170595429 no 3021 0.0746780379499946 4449 4011476 SGTC_3127 9126946 49.47 µM -1.44362896285423 0.100224197392921 no 3022 0.0744216866800707 4412 27243249 SGTC_846 0335-0850 148 µM -1.44524573490966 0.0999740988357611 no 3023 0.0741944371103211 4446 6819598 SGTC_1668 st014914 51.6 µM -1.44646394601816 0.0997859549909765 no 3024 0.0740235587121859 4469 2839556 SGTC_1306 1185-0270 9.02 µM -1.44944971356869 0.0993259190337362 no 3025 0.0736060169734657 4484 1548076 SGTC_1142 3253-1408 9.78 µM -1.45215890159767 0.0989098409070662 no 3026 0.0732287136317319 4479 256655 SGTC_2057 5236571 38.335 µM -1.45221842555396 0.098900713533639 no 3027 0.0732204404897024 4410 54684039 YBR257W POP4 SGTC_1712 st032288 53.4 µM -1.45224188643949 0.0988971162226011 no 3028 0.073217179894217 4276 2883011 SGTC_793 0488-0545 106 µM -1.45425378657282 0.0985889829991942 no 3029 0.0729379789056381 4482 292548 SGTC_2324 6149169 200 µM -1.45483405528858 0.0985002424716191 no 3030 0.0728576038581992 4400 2888231 SGTC_1007 4101-0031 70 µM -1.45723079591717 0.0981343283967715 no 3031 0.0725263412150503 4452 1146276 SGTC_1976 st070609 63.5 µM -1.45751228568136 0.0980914183568526 no 3032 0.0724875112729826 4417 682556 SGTC_1805 st050013 60.3 µM -1.45766432872173 0.0980682467748171 no 3033 0.0724665444092853 4412 4037144 SGTC_1606 st000094 49.2 µM -1.45983671201973 0.097737610295646 no 3034 0.0721674781098327 4490 1242210 SGTC_2898 9056270 58.44 µM -1.46246260579324 0.0973390414514984 no 3035 0.0718072421602619 4486 19154699 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.46487713482732 0.0969736078920457 no 3036 0.0714772210807333 4546 4213774 SGTC_277 nystatin 15.5 µM -1.46682366088773 0.0966797395589015 no 3037 0.071212015710195 4496 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_826 1683-5028 118 µM -1.46694772737297 0.0966610313567154 no 3038 0.0711951378580096 4516 722377 SGTC_1351 1496-0003 46.5 µM -1.46737441743273 0.0965967103149828 no 3039 0.0711371149113907 4493 3891978 SGTC_1122 capsaicin 818.572 nM -1.4675593686444 0.0965688397667784 no 3040 0.071111975821598 4519 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_606 k015-0008 38.6 µM -1.47710789202063 0.0951379738195125 no 3041 0.0698233591881841 4534 1970475 SGTC_522 1273-0010 11.6 µM -1.47737977997808 0.0950974607131482 no 3042 0.0697869315835879 4497 5705015 SGTC_3162 9099653 49.47 µM -1.477709221726 0.0950483887379896 no 3043 0.0697428125122716 4463 25237511 SGTC_623 k072-0108 16.9 µM -1.49035535649945 0.0931787581042272 no 3044 0.0680654121726922 4456 5382803 SGTC_1946 st076057 65.1 µM -1.49605624478197 0.0923448703853608 no 3045 0.0673194994265011 4478 953009 SGTC_611 3453-1652 23.7 µM -1.49830421764057 0.0920175746498831 no 3046 0.067027114392513 4500 1560575 SGTC_650 1328-0195 38 µM -1.4985641045437 0.0919797916324405 no 3047 0.0669933753549648 4497 2780821 SGTC_1523 st012844 44.7 µM -1.49997787518729 0.0917744552867586 no 3048 0.0668100668689544 4532 4274103 SGTC_718 1130-0073 349 µM -1.50254836508135 0.0914019871000749 no 3049 0.0664777735352717 4506 6740020 SGTC_1794 st048918 76.9 µM -1.50308595492196 0.0913242313323953 no 3050 0.0664084400720031 4469 672303 SGTC_1927 st060202 13.8 µM -1.50324306913149 0.0913015159546049 no 3051 0.0663881874820745 4428 688887 SGTC_3152 9099253 49.47 µM -1.50339490892913 0.0912795671253557 no 3052 0.0663686193274898 4361 25236131 SGTC_1031 k035-0009 16 µM -1.50780977092817 0.0906430969618131 no 3053 0.0658016103437845 4538 5180959 SGTC_537 1334-0398 209 µM -1.50836053549333 0.0905639274638536 no 3054 0.0657311388348456 4521 5846986 SGTC_1201 1889-3372 45.9 µM -1.50917131229773 0.090447475998368 no 3055 0.0656275046752733 4406 5392199 SGTC_1340 1486-1359 257 µM -1.51012272954727 0.0903109662414699 no 3056 0.0655060553420038 4446 4309068 SGTC_654 1124-0271 80.9 µM -1.51097277081941 0.0901891314314336 no 3057 0.0653976942433218 4492 5403748 SGTC_217 ketoconazole 989 nM -1.51146598045087 0.090118496621191 no 3058 0.0653348849039348 4307 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2262 9014885 67.46 µM -1.51167110929368 0.0900891312842485 no 3059 0.0653087759055829 4534 6457424 SGTC_2474 5321570 43.32 µM -1.51211828923898 0.0900251396259289 no 3060 0.0652518864640291 4501 2841384 SGTC_133 0724-0033 378.92 µM -1.51242744831855 0.0899809185683233 no 3061 0.0652125782768573 4392 280309 SGTC_1317 1273-0028 910 nM -1.51341801689431 0.0898393397404785 no 3062 0.0650867556717091 4517 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_3271 9137798 49.47 µM -1.51461271471022 0.0896688057215655 no 3063 0.0649352551848737 4503 6498326 SGTC_7 0192-1582 4.227 µM -1.51516620847038 0.0895898803311405 no 3064 0.0648651591014245 4562 252616 SGTC_446 go6976 132 µM -1.5155253937658 0.089538689983526 no 3065 0.0648197022559925 4511 3501 A protein kinase C inhibitor. SGTC_739 1486-1183 203 µM -1.51558988003461 0.0895295018371018 no 3066 0.0648115437888104 4494 4346692 SGTC_1531 st059297 52.4 µM -1.51635078334351 0.0894211395917388 no 3067 0.0647153384583172 4538 7566702 SGTC_1468 k284-1086 134 µM -1.52265622902867 0.0885269158132472 no 3068 0.063922367089624 4514 15996457 SGTC_135 0933-0004 26.348 µM -1.52702410969369 0.087911390142594 no 3069 0.0633775081439355 4439 21230617 YGL099W LSG1 SGTC_3287 9117173 37.0625 µM -1.53079378884153 0.0873827343606674 no 3070 0.0629101825858365 4533 2789709 SGTC_546 peri-Naphthalide 147 µM -1.53099280603205 0.0873548904946511 no 3071 0.0628855853141321 4457 223824 A penicillin ester. SGTC_3226 9131256 49.47 µM -1.53375183874955 0.0869695650422134 no 3072 0.062545357695631 4524 17178073 SGTC_2518 prenyletin 46.28 µM -1.53516343341347 0.0867729139108723 no 3073 0.0623718439585647 4540 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2493 resveratrol 26.09 µM -1.53587871517103 0.0866733939874615 no 3074 0.0622840646732437 4472 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1688 st021091 57.6 µM -1.53656770971311 0.0865776121905336 no 3075 0.0621996024844811 4546 3656366 SGTC_1123 mangostin 811.285 nM -1.53827664523015 0.0863403830257743 no 3076 0.0619904938063549 4515 5281650 An antioxidant. SGTC_2747 doxorubicin 7.63 µM -1.53900130258505 0.0862399352169667 no 3077 0.0619019891221128 4575 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1041 0206-0046 107 µM -1.54176393076832 0.08585779738768 no 3078 0.0615654850176922 4523 50494 SGTC_3016 9080866 49.47 µM -1.54340114521001 0.0856319301772441 no 3079 0.0613667380009802 4491 17066299 SGTC_3342 9147791 14.508 µM -1.54752269538714 0.0850652984951649 no 3080 0.0608686280667366 4481 1838168 SGTC_803 4488-1585 147 µM -1.54787564091289 0.0850169063952011 no 3081 0.0608261202133886 4517 747204 SGTC_2462 5162487 171.77 µM -1.54925409763756 0.0848281048696112 no 3082 0.0606603247571549 4481 2259986 SGTC_112 phenothiazine 287.218 µM -1.54987050167662 0.0847437803435747 no 3083 0.0605863005262104 4483 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_3095 9117207 49.47 µM -1.55213134982822 0.0844350327067019 no 3084 0.0603153990656747 4524 17015229 SGTC_1115 galangin 695.678 nM -1.55368095915415 0.0842239017873554 no 3085 0.0601302685667403 4585 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_4 0960-0234 25.671 µM -1.55576311636224 0.0839408366137029 no 3086 0.0598822158800385 4508 6821112 SGTC_1508 1080-0625 72.9 µM -1.55630784577812 0.0838668997531829 no 3087 0.0598174533327749 4462 767111 SGTC_3063 1327-0034 4 µM -1.55700549082346 0.0837722788945317 no 3088 0.0597345908875469 4409 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1742 st038235 28.8875 µM -1.56050601682996 0.0832987165633721 no 3089 0.0593201746097888 4556 564103 YBR002C RER2 SGTC_2879 9041815 71.43 µM -1.56130266053567 0.0831912257223313 no 3090 0.0592261780802223 4567 4942971 SGTC_3323 9138564 53.9225 µM -1.56259303079418 0.0830173378754596 no 3091 0.059074174282027 4547 43912313 YNL103W MET4 SGTC_2491 paeonol 100 µM -1.56351604655195 0.0828931218361308 no 3092 0.0589656321860282 4504 11092 Increases levels of cortical cytochrome oxidase. SGTC_631 k072-0230 41.5 µM -1.56507566928801 0.0826835514020169 no 3093 0.0587825838804287 4519 5773147 SGTC_1073 triclabendazole 3.09 µM -1.56581799941691 0.0825839428043997 no 3094 0.0586956155819985 4567 50248 An antihelmetic and likely tubulin inhibitor. SGTC_492 tmb-8 126 µM -1.56701104608433 0.0824240446711912 no 3095 0.0585560548496994 4558 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1210 3013-0140 750 nM -1.57013876391001 0.082005958833303 no 3096 0.0581914160279588 4547 905973 SGTC_2770 toltrazuril 17.5 µM -1.57224946360181 0.0817247233417333 no 3097 0.0579463540752313 4461 68591 Kills coccidiodes. SGTC_110 0850-0284 111.64 µM -1.5735794947235 0.0815478800941278 no 3098 0.0577923484365165 4445 3906265 SGTC_3111 9122088 49.47 µM -1.57419784382792 0.0814657616515555 no 3099 0.0577208588418084 4471 16876704 SGTC_2742 clothiapine 36.27 µM -1.57467356145994 0.0814026275138355 no 3100 0.0576659067329421 4575 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_3224 9130643 49.47 µM -1.58124462983617 0.0805343298018336 no 3101 0.0569110572219228 4536 17644395 SGTC_84 0443-0269 128.823 µM -1.5840038301703 0.0801718231902241 no 3102 0.05659642374371 4489 6150058 SGTC_1176 0848-0131 83.3 µM -1.58551122537431 0.0799743017114273 no 3103 0.0564251142528403 4584 6769040 SGTC_2204 7233102 200 µM -1.58672113515136 0.079816027602465 no 3104 0.0562879086760002 4531 2172480 SGTC_2738 aclarubicin 5.55 µM -1.59033611907985 0.0793445455547215 no 3105 0.0558795306068054 4586 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_3195 9113082 49.47 µM -1.59108396308279 0.0792472721729577 no 3106 0.0557953405613665 4525 17018038 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.59242471250017 0.0790731046126727 no 3107 0.0556446535898109 4509 1241132 A phosphatase inhibitor. SGTC_735 3076-0345 636 µM -1.59693158708855 0.0784897721773699 no 3108 0.055140478923435 4561 2888990 SGTC_1069 diphenylcyclopropenone 8.49 µM -1.59861698683601 0.0782724681103958 no 3109 0.054952866479237 4576 65057 A dermal irritant. YDR527W RBA50 SGTC_1422 4031-0024 15.5 µM -1.60469343797909 0.077492798336427 no 3110 0.0542806433814317 4495 782427 SGTC_352 k048-0007 5.11 µM -1.60611988413527 0.0773106285955267 no 3111 0.0541237858811959 4471 6811911 SGTC_3176 9106582 49.47 µM -1.60786319538198 0.0770884343434682 no 3112 0.0539325720452245 4567 17018027 SGTC_628 1636-0253 16 µM -1.60835112734279 0.0770263318356573 no 3113 0.0538791494849994 4542 4456143 SGTC_443 clozapine 122 µM -1.61351697338403 0.0763711689612675 no 3114 0.0533161193491309 4550 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3265 9137266 49.47 µM -1.61359164856383 0.076361729404315 no 3115 0.0533080147598289 4530 17224265 SGTC_2860 9025725 38.96 µM -1.61424291967553 0.0762794410095642 no 3116 0.0532373728914745 4591 40546248 SGTC_2346 9031566 143.75 µM -1.61913199216409 0.0756638578743782 no 3117 0.0527094333363492 4536 4771086 SGTC_910 3454-3003 490 µM -1.62666583741164 0.0747226907003255 no 3118 0.0519040440594473 4467 820824 SGTC_406 estrone 100 µM -1.62980522692542 0.0743331490448759 no 3119 0.0515713343693001 4557 5870 A steroid. SGTC_2625 euphol 100 µM -1.63029533635359 0.0742724754910937 no 3120 0.0515195463822564 4544 6708538 A triterpene alcohol. SGTC_3150 9097574 49.47 µM -1.63099046720625 0.0741864859888973 no 3121 0.0514461654980397 4583 17217476 SGTC_3190 9110366 49.47 µM -1.63759101777497 0.073373765661755 no 3122 0.0507535190254035 4568 17123768 SGTC_1370 2001-0092 44.6 µM -1.64855308181816 0.0720390864731078 no 3123 0.0496196137329692 4539 790957 SGTC_279 1273-0055 2.93 µM -1.64864480333845 0.072027998028139 no 3124 0.0496102121388326 4614 2847562 SGTC_3040 9091894 49.47 µM -1.6525763852905 0.0715539283324973 no 3125 0.0492085537024778 4476 25236966 SGTC_2932 9016711 44.54 µM -1.65329021416261 0.0714681123203626 no 3126 0.0491359068172377 4548 7117328 SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.65580848189931 0.0711659986534035 no 3127 0.0488803047803692 4600 77254 SGTC_1261 0712-0010 12.7 µM -1.65639442715674 0.0710958443061986 no 3128 0.0488209844642832 4556 2840123 SGTC_2748 diazoxide 86.69 µM -1.65828090787654 0.0708703395047247 no 3129 0.0486303903762666 4648 3019 A potassium channel activatior. SGTC_2741 miltefosine 3.04 µM -1.65836365356416 0.0708604609030754 no 3130 0.0486220440875622 4609 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2861 9024595 19.48 µM -1.66347079962781 0.0702527890420473 no 3131 0.0481091156240102 4536 16482810 SGTC_234 nsc-17383 10.7 µM -1.67208062272019 0.0692374361928986 no 3132 0.047254212541874 4582 408974 SGTC_1162 k048-0130 20.1 µM -1.67554520256187 0.0688320643380475 no 3133 0.0469136549736188 4576 6797406 SGTC_1618 st003135 44.5 µM -1.67746091165271 0.0686087044817535 no 3134 0.0467261934515105 4560 1270615 SGTC_3289 9119912 71.43 µM -1.68243332262634 0.0680315606883277 no 3135 0.0462424221426585 4571 17014829 SGTC_1834 st055981 52.8 µM -1.68490287782809 0.0677463179954587 no 3136 0.0460036556322993 4568 471719 YDL150W RPC53 SGTC_1303 1160-0052 261 µM -1.68526162255327 0.0677049586228366 no 3137 0.0459690532876106 4539 3562476 SGTC_16 erodoxin 22.806 µM -1.68821544638571 0.0673651559352833 no 3138 0.0456849395847863 4633 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1602 st001878 87.6 µM -1.69167108938064 0.0669692997467985 no 3139 0.0453543518481619 4557 595405 YLR310C CDC25 SGTC_2740 felodipine 17.08 µM -1.69339663820971 0.0667723067291391 no 3140 0.0451899971807821 4649 3333 L-type calcium channel blocker SGTC_3039 9090270 49.47 µM -1.69524960634667 0.0665612667758815 no 3141 0.0450140400581697 4587 17173750 SGTC_2461 5755302 26.15 µM -1.69772641356939 0.0662799827231589 no 3142 0.0447797050471729 4578 2788904 SGTC_862 0452-0056 10.2 µM -1.70349502110407 0.0656284274802691 no 3143 0.0442377344852566 4551 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1570 verbenone 133 µM -1.70544676155558 0.0654091093270716 no 3144 0.0440555667195262 4596 29025 A natural terpanoid with antifungal properties. SGTC_2545 solidagenone 89.61 µM -1.70645387835058 0.0652961616283788 no 3145 0.0439618032649946 4546 6708572 An anti ulcer agent SGTC_283 0987-0079 11.7 µM -1.70816016747182 0.0651051474709125 no 3146 0.0438033136214574 4587 411556 SGTC_1650 st011916 45.8 µM -1.71392377811387 0.0644631330015966 no 3147 0.0432713627046286 4570 242528 SGTC_1705 st027868 56.3335 µM -1.71674674515629 0.0641504796963383 no 3148 0.0430127275665096 4525 292948 SGTC_639 0833-0042 114 µM -1.72007708810101 0.0637831498358688 no 3149 0.0427092149511851 4609 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1855 st056195 39.6 µM -1.72083299571312 0.0637000030726605 no 3150 0.0426405665460333 4533 4028379 SGTC_2014 4013930 200 µM -1.72463890780583 0.0632826486900694 no 3151 0.0422962835351229 4572 64556 SGTC_763 3453-1109 128 µM -1.7310411065208 0.0625853933219615 no 3152 0.0417222165593944 4631 1560353 SGTC_2004 4023728 41.89 µM -1.7365648614182 0.0619886334096727 no 3153 0.0412320031789511 4554 360084 YDR527W RBA50 SGTC_3061 glucosamine 200 µM -1.73990274110745 0.0616301829664526 no 3154 0.0409380486499578 4543 91431 and experimental redox chemotherapeutic SGTC_2764 methyldopa 94.69 µM -1.74842687787117 0.0607221308406543 no 3155 0.0401950685614103 4563 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_3177 9107506 49.47 µM -1.75245941271105 0.0602962184289691 no 3156 0.0398474215212739 4594 8897194 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.76561629766908 0.0589228459675244 no 3157 0.0387301219509676 4656 165521 SGTC_1885 st057546 99.9 µM -1.7661015583192 0.058872665624418 no 3158 0.0386894060468664 4634 702008 SGTC_1343 1487-0095 224 µM -1.76691527637955 0.0587885950817025 no 3159 0.0386212091220049 4600 4560101 YGL055W OLE1 SGTC_2711 st079103 59.1 µM -1.76779173437843 0.05869814789115 no 3160 0.0385478636249874 4559 54693780 SGTC_2469 5655019 90.81 µM -1.76944087963965 0.0585282584143666 no 3161 0.0384101643285403 4665 2788239 SGTC_3018 9082602 49.47 µM -1.77004954810209 0.0584656530387307 no 3162 0.0383594435245514 4502 17332089 SGTC_886 0866-0150 153 µM -1.77950331601368 0.057500010150681 no 3163 0.0375786408640984 4642 271463 SGTC_3252 9135871 49.47 µM -1.78612087219561 0.0568315653905819 no 3164 0.0370398446681946 4639 17682838 SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.80179645445025 0.0552725792193191 no 3165 0.035788717891439 4605 6708630 An antioxidant. SGTC_884 0851-0618 334 µM -1.80185157643866 0.0552671573701261 no 3166 0.0357843802737576 4644 9642473 SGTC_1272 0839-0021 27 µM -1.80928744735349 0.0545396005593206 no 3167 0.035203179053237 4685 5027250 SGTC_3069 9117009 49.47 µM -1.81029932903729 0.0544411820159519 no 3168 0.0351246905279304 4645 41904981 SGTC_2384 9036245 200 µM -1.81160233646484 0.0543146547158464 no 3169 0.0350238318361223 4609 6462766 SGTC_3186 9110464 49.47 µM -1.81463253681908 0.0540213095987049 no 3170 0.0347901994355942 4624 17018021 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.83050973729804 0.0525047302189303 no 3171 0.0335868760385808 4591 4000243 SGTC_1426 4048-4480 71.7 µM -1.83166068283883 0.0523961198134512 no 3172 0.0335009949055329 4653 14224343 SGTC_1309 pyrazolanthrone 13.4 µM -1.84562258189524 0.0510927462250936 no 3173 0.032473512647711 4642 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_218 alverine citrate 93.75 µM -1.84866265159645 0.0508123986239238 no 3174 0.0322532699313366 4683 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2015 5119600 184 µM -1.85401007976981 0.0503222455079184 no 3175 0.0318688589675189 4617 2828786 SGTC_2295 7971645 200 µM -1.85892265687609 0.0498752793858085 no 3176 0.0315190510521875 4670 2978226 YKL099C UTP11 SGTC_327 1273-0057 3.96 µM -1.85913610242622 0.0498559312581482 no 3177 0.0315039245529842 4579 3108138 SGTC_2435 5706476 10.6 µM -1.86074642502355 0.0497101537784673 no 3178 0.0313899972229622 4634 5725375 SGTC_2933 9026794 32.47 µM -1.86417934649229 0.0494005174287405 no 3179 0.0311482613740844 4584 17586027 SGTC_1872 amphotericin b 148 nM -1.86563957675067 0.0492692778757599 no 3180 0.0310459042975346 4667 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1499 4480-0877 67.3 µM -1.86885373822741 0.0489813829462478 no 3181 0.0308215830233774 4665 2861909 SGTC_2651 TUB2.036 5 µM -1.86991525113549 0.0488865981887916 no 3182 0.0307477937900766 4521 15992207 YFL037W TUB2 SGTC_1010 4112-3296 15.2 µM -1.8711522342625 0.0487763302897966 no 3183 0.0306619916355791 4658 704384 SGTC_2278 7948257 134.34 µM -1.87868106451005 0.0481094712171415 no 3184 0.0301440274243998 4647 1247028 SGTC_790 1575-0012 79.1 µM -1.87942167534226 0.0480442683633935 no 3185 0.030093469495092 4667 378741 YLR208W SEC13 SGTC_1730 st033808 45.1 µM -1.88048032919781 0.0479511880489763 no 3186 0.0300213223920801 4584 1045166 SGTC_2428 5615643 7.78 µM -1.88320134158512 0.0477126099412865 no 3187 0.0298365436580177 4654 2253075 SGTC_426 0988-0037 14.6 µM -1.88459069705202 0.047591158503741 no 3188 0.0297425596357705 4636 5383008 SGTC_829 1635-0120 117 µM -1.88768996260534 0.0473211264113363 no 3189 0.0295337923299141 4634 285054 SGTC_2331 7980721 200 µM -1.89023080721086 0.0471006654273725 no 3190 0.0293635490765642 4613 2981221 SGTC_487 nimodipine 119 µM -1.89538402261524 0.0466560662091332 no 3191 0.0290207719295833 4678 4497 L-type voltage-gated calcium channels inhibitor SGTC_354 2783-3500 4.88 µM -1.89559903816454 0.0466375889455264 no 3192 0.0290065422805389 4643 6740761 SGTC_1260 0700-1617 7.75 µM -1.89680755809853 0.0465338445572601 no 3193 0.028926670720445 4610 2853078 SGTC_3334 9142812 21.919 µM -1.89970427697598 0.0462859320842216 no 3194 0.0287359693752379 4643 45283678 SGTC_1246 0422-0085 105 µM -1.90043419001214 0.0462236308587944 no 3195 0.0286880818337108 4621 264295 SGTC_1799 st045822 46.1415 µM -1.90459999415605 0.0458693493496875 no 3196 0.0284160436804367 4649 3674992 SGTC_861 0443-0273 110 µM -1.9061698771023 0.0457364058062792 no 3197 0.0283140845348601 4653 6149169 SGTC_1169 aniline yellow 25.8 µM -1.90818372276991 0.0455663195008635 no 3198 0.0281837373322027 4617 6051 A DNA damaging agent. SGTC_1561 5-methoxyflavone 52.9 µM -1.9089388674381 0.0455026723982168 no 3199 0.0281349891569811 4643 94525 SGTC_3047 9092122 49.47 µM -1.91878987601151 0.0446789153510642 no 3200 0.0275054658109921 4639 17173831 SGTC_3205 9113483 49.47 µM -1.91941674422187 0.0446269047588986 no 3201 0.0274658067644896 4622 17018033 SGTC_1089 terbinafine 2.25 µM -1.92378604385661 0.0442657417773214 no 3202 0.0271907037409981 4679 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1988 st071872 53.4 µM -1.92644936030017 0.0440467522061811 no 3203 0.0270241445759996 4688 16414116 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.92792525151215 0.0439257746378108 no 3204 0.0269322121731896 4655 2724278 An inhibitor of dopamine biosynthesis. SGTC_2550 chrysin dimethyl ether 71.87 µM -1.93246708608911 0.0435551647321986 no 3205 0.0266509403664039 4575 88881 An O-methylated flavonoid and antioxidant. SGTC_2619 obliquin 87.91 µM -1.9390774225091 0.0430202805885667 no 3206 0.0262459557081611 4644 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1727 st034309 9.9045 µM -1.94692073804777 0.0423925258701666 no 3207 0.0257721189872655 4658 870305 SGTC_3261 9137475 49.47 µM -1.94931040267593 0.0422027440002073 no 3208 0.0256291835120364 4708 17027690 SGTC_1307 1187-1599 12.2 µM -1.95218016438713 0.0419757430598502 no 3209 0.0254584091565256 4694 1538471 SGTC_3336 9143619 71.43 µM -1.95505209713197 0.041749560964936 no 3210 0.0252884607408245 4669 45595730 SGTC_2790 5423970 71.43 µM -1.95637141983605 0.0416459876974571 no 3211 0.0252107082014371 4649 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1906 st060206 94.7 µM -1.96441486409868 0.041019032598251 no 3212 0.0247410002334831 4680 5133468 SGTC_1654 st012436 41.8 µM -1.96588340322401 0.0409053963021286 no 3213 0.0246560403183549 4695 4323132 SGTC_360 0957-0399 1.01 µM -1.96866018084712 0.0406912258646186 no 3214 0.0244960633842461 4674 6752301 YPR165W RHO1 SGTC_2716 st080858 38.6235 µM -1.9727777186735 0.0403753198420238 no 3215 0.0242604463941833 4654 5296050 SGTC_2918 7977171 22.06 µM -1.97683438733073 0.0400660343255846 no 3216 0.0240301766621616 4665 2236483 SGTC_1487 3970-0795 2.82 µM -1.9813098389241 0.0397270565561801 no 3217 0.0237782688421821 4704 3765103 SGTC_2914 7968218 45.32 µM -1.98257350390546 0.0396317678631422 no 3218 0.0237075447161138 4661 2977111 SGTC_2292 7671323 168.05 µM -1.98432108095067 0.039500295346354 no 3219 0.0236100287791004 4670 937504 SGTC_2466 5983409 37.09 µM -1.98453950209304 0.0394838882068481 no 3220 0.0235978644876866 4682 2879657 SGTC_2763 lisinopril 49.32 µM -1.98786215062285 0.0392349837407195 no 3221 0.0234134688868883 4608 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3266 9136860 49.47 µM -1.99523795691899 0.0386870138905356 no 3222 0.0230084665303067 4440 4871271 YPR165W RHO1 SGTC_568 1193-0097 7.48 µM -2.00449128929573 0.0380083922024206 no 3223 0.0225087295428162 4498 3646150 SGTC_2167 5876490 200 µM -2.01157020754237 0.0374958206265472 no 3224 0.0221326312826215 4680 686534 SGTC_2052 5265182 7.135 µM -2.01215711944116 0.0374535780345139 no 3225 0.02210168853854 4658 1239884 SGTC_80 0159-0065 512.242 µM -2.01446324787365 0.037287972220789 no 3226 0.0219804598693905 4669 1548079 SGTC_1315 1237-0019 3.69 µM -2.02241149683756 0.036721777502172 no 3227 0.0215669291624181 4684 825140 SGTC_2221 6807166 181.081 µM -2.02730777769519 0.0363765037874256 no 3228 0.0213154733003569 4700 674925 SGTC_1882 5615643 20 µM -2.02877402739763 0.0362736259624735 no 3229 0.0212406559367764 4695 2253075 SGTC_1540 guanosine 70.6 µM -2.03006898994194 0.036182964498501 no 3230 0.0211747635501808 4665 6802 Guanosine is a purine nucleoside SGTC_2077 5212015 200 µM -2.0323094106998 0.0360265488874888 no 3231 0.0210611711842955 4652 780900 SGTC_2048 5246248 200 µM -2.03287686702474 0.0359870197827125 no 3232 0.0210324823539436 4706 677046 SGTC_199 4063-0024 41.6 µM -2.04083711967794 0.0354362424701287 no 3233 0.0206335098136153 4732 306215 SGTC_424 splitomicin 100 mM -2.04727678167657 0.0349957508190478 no 3234 0.0203154581345 4670 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3230 9131665 49.47 µM -2.05510408462442 0.0344664016976869 no 3235 0.0199344762462837 4719 15943720 SGTC_798 1287-0182 476 µM -2.0608620120614 0.0340812156873469 no 3236 0.0196581031664765 4726 1649755 SGTC_1793 st048256 72.231 µM -2.06751705757182 0.0336404325277003 no 3237 0.0193427292926933 4713 672022 SGTC_1907 st060210 83.7 µM -2.0693539623002 0.033519598557865 no 3238 0.0192564416481133 4686 688793 SGTC_1270 0831-1170 17.3 µM -2.07344675406158 0.0332516540336913 no 3239 0.0190653607975137 4713 6764716 SGTC_394 menadione 8.33 µM -2.08078537173045 0.0327756319473227 no 3240 0.0187267778488058 4689 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1938 st074717 56.4 µM -2.08315416380047 0.0326231841349038 no 3241 0.0186185868017508 4611 17250979 SGTC_2309 7664088 163.95 µM -2.0898843527876 0.0321932391945084 no 3242 0.0183140947476476 4677 704922 SGTC_2476 5806916 10.51 µM -2.0928167526554 0.0320073770052556 no 3243 0.0181827578785072 4660 2870194 SGTC_740 k014-0057 261 µM -2.09341591143246 0.0319695101834777 no 3244 0.0181560216328293 4695 4012779 SGTC_1310 1188-0297 994 nM -2.09889610415419 0.0316248759540047 no 3245 0.0179130301830231 4625 1588352 SGTC_1200 1643-0193 18.4 µM -2.1043919614429 0.0312823458753746 no 3246 0.0176721350240336 4725 5403974 SGTC_1493 4348-0038 111 µM -2.10703083619635 0.0311189711869259 no 3247 0.0175574533668803 4713 800424 SGTC_780 0109-0199 192 µM -2.10705681543677 0.0311173663085137 no 3248 0.0175563275122725 4713 610414 SGTC_815 1582-0027 36.9 µM -2.11121109721641 0.0308616133309966 no 3249 0.0173770857074602 4710 3128206 SGTC_784 4579-0127 173 µM -2.1135261016439 0.0307198496501468 no 3250 0.0172778816843512 4716 1948547 SGTC_2073 5212005 126 µM -2.1150776121874 0.0306251420630652 no 3251 0.0172116664923307 4674 691789 SGTC_3183 9108214 49.47 µM -2.11540008458878 0.0306054880267197 no 3252 0.0171979312996974 4735 4974831 SGTC_3262 9137218 49.47 µM -2.11762371543139 0.0304702464394305 no 3253 0.0171034740332051 4725 17650664 SGTC_1903 st060211 78.3 µM -2.11776205162922 0.0304618491933144 no 3254 0.0170976123497956 4706 688960 SGTC_41 0478-0632 82.643 µM -2.12236766074489 0.0301833733140025 no 3255 0.0169034378436713 4677 3750424 SGTC_1739 st037196 92.5 µM -2.12797100194228 0.0298474189026994 no 3256 0.0166697439611177 4704 612214 SGTC_357 1325-0123 420 µM -2.12998604759198 0.0297273654794631 no 3257 0.0165863826410147 4701 1098503 SGTC_683 panaxydol 45 µM -2.13845433773332 0.0292272091213332 no 3258 0.0162399431867143 4716 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2220 6782180 200 µM -2.14470493642282 0.028862535106287 no 3259 0.0159882229843552 4714 833803 SGTC_1832 st054113 55 µM -2.1543861510059 0.0283051826284979 no 3260 0.0156049508657234 4734 1251267 SGTC_2915 7971052 15.16 µM -2.16513115625448 0.0276971048106615 no 3261 0.015188821298255 4686 5741558 SGTC_2803 7707263 71.43 µM -2.16819064039912 0.0275259681376842 no 3262 0.0150720923244931 4683 2199229 SGTC_1143 3454-2408 5.08 µM -2.16922375603086 0.0274683787913566 no 3263 0.0150328502077661 4732 X1143 SGTC_1138 3761-0006 1.03 µM -2.17223332320718 0.0273011876986664 no 3264 0.0149190341947723 4728 12061087 SGTC_2746 daunorubicin 9.88 µM -2.1751190168146 0.0271416761429758 no 3265 0.0148105993718891 4742 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1590 st077108 57.8 µM -2.17663029523015 0.0270584484370851 no 3266 0.0147540814512534 4729 5489485 SGTC_1811 st050069 61.5 µM -2.17665255476646 0.0270572241741966 no 3267 0.0147532503901562 4724 3877702 SGTC_1717 st033143 58.0435 µM -2.18856111332275 0.0264088548770777 no 3268 0.0143143774077446 4702 674616 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -2.19109966374738 0.0262723340553512 no 3269 0.0142222905333166 4729 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1088 bifonazole 369 nM -2.19859142827353 0.025872869802357 no 3270 0.0139534935081147 4726 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1997 st073024 93.8 µM -2.20008241727657 0.0257939790011535 no 3271 0.0139005240592177 4750 686268 SGTC_807 1315-0151 48 µM -2.20497598495411 0.0255364652209796 no 3272 0.0137278898822864 4713 4011080 SGTC_2602 kawain 100 µM -2.2053520838282 0.0255167632026358 no 3273 0.0137146988219607 4693 5369129 SGTC_85 0868-0259 160.055 µM -2.21024305062297 0.0252617059259715 no 3274 0.0135441493264171 4705 83173 SGTC_2834 9001755 58.44 µM -2.21761413385663 0.0248813518547446 no 3275 0.0132905766822869 4597 2989575 SGTC_57 miconazole 162.5 nM -2.22053013285164 0.0247322153581274 no 3276 0.0131914012783751 4603 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1320 1313-0481 95.3 µM -2.22542152900577 0.0244837328816958 no 3277 0.013026476797481 4696 6813365 YLR208W SEC13 SGTC_716 1683-5115 658 µM -2.22639992405831 0.0244342828217889 no 3278 0.012993702785917 4716 723597 SGTC_2946 9065502 71.43 µM -2.22803229595092 0.0243519660921204 no 3279 0.0129391807204264 4679 16489101 SGTC_540 1187-0821 17.3 µM -2.2389093879652 0.0238093840252789 no 3280 0.0125809062630014 4690 847520 SGTC_945 3381-0768 11.3 µM -2.24565129358629 0.0234782067196913 no 3281 0.0123631761180655 4713 1126236 YIL048W NEO1 SGTC_2582 agaric acid 100 µM -2.26642907797863 0.0224818378466637 no 3282 0.0117125624596294 4445 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_3096 9117468 49.47 µM -2.26774504353749 0.0224199517587754 no 3283 0.0116723753681962 4736 41316311 SGTC_1877 wortmannin 25 µM -2.27082599034362 0.0222756254157767 no 3284 0.0115787569665783 4736 312145 A covalent inhibitor of PI 3-kinase. SGTC_882 0843-0131 351 µM -2.2981946070391 0.0210276219820663 no 3285 0.0107753577554126 4749 5425421 SGTC_2796 7949634 45.45 µM -2.31995024496693 0.0200782553443006 no 3286 0.0101717845254822 4719 2971588 SGTC_1642 st009582 77.7 µM -2.32741600300671 0.0197609584681723 no 3287 0.00997156742014893 4741 6739311 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -2.33189224141673 0.019572765765524 no 3288 0.00985318037144838 4702 279621 SGTC_2584 androsterone 48.74 µM -2.33248753390522 0.0195478531604154 no 3289 0.00983752898414974 4655 2754130 A steroid. SGTC_2745 rifampicin 24.3 µM -2.33320105631867 0.0195180281988582 no 3290 0.0098187977171765 4793 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_418 lividomycin a 100 µM -2.3346165094236 0.0194589771798965 no 3291 0.00978173165781158 4748 72394 An antibiotic. SGTC_58 0957-0393 9 µM -2.34700279938159 0.0189486807502886 no 3292 0.0094625562966632 4289 6997992 SGTC_939 1165-0479 45.3 µM -2.34707152047907 0.018945881604958 no 3293 0.00946081117198761 4721 1377347 SGTC_1652 st011932 78 µM -2.34830016640575 0.0188958957674267 no 3294 0.00942965802365584 4726 1551076 SGTC_1758 st042942 75.2445 µM -2.34966899069779 0.018840339119935 no 3295 0.00939505624753445 4725 669317 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -2.35420074695173 0.0186573987899262 no 3296 0.00928129165128761 4745 688662 SGTC_130 0136-0219 337.655 µM -2.37401079280016 0.0178753464254447 no 3297 0.00879801807207392 4700 234244 SGTC_911 3456-4043 236 µM -2.37699281324162 0.0177600792650101 no 3298 0.00872721409805834 4722 914281 SGTC_1923 st058458 19.1 µM -2.38363287538498 0.0175056903155768 no 3299 0.00857134726297709 4727 3534982 SGTC_3343 9148379 18.9835 µM -2.38629516485134 0.0174045719101158 no 3300 0.00850954265676343 4764 1955036 SGTC_1714 st033236 13.627 µM -2.39014228980116 0.0172593327907955 no 3301 0.00842092320275882 4735 2916566 SGTC_2107 5363541 170.161 µM -2.4058981251282 0.0166752633320825 no 3302 0.00806638141473438 4725 244052 SGTC_822 1487-0950 154 µM -2.43143881052838 0.0157644015540682 no 3303 0.00751949415826846 4737 1958375 SGTC_1891 st059073 26.2 µM -2.4609378999236 0.0147657938266921 no 3304 0.0069287174677661 4774 688754 SGTC_3064 1327-0027 10 µM -2.465256609483 0.014624261507098 no 3305 0.00684575790571549 4748 16000455 YPR107C YTH1 SGTC_2791 5663188 71.43 µM -2.46836777574085 0.014523027440876 no 3306 0.00678653933079272 4735 54690634 SGTC_1140 3229-1848 2.98 µM -2.50160212013869 0.0134787182476408 no 3307 0.00618163905883572 4754 2849525 SGTC_3060 1327-0027 12.5 µM -2.54164546945169 0.0123071225910934 no 3308 0.00551660116550407 4719 16000455 YPR107C YTH1 SGTC_1004 4084-0029 199 µM -2.56074418370142 0.0117801192790396 no 3309 0.00522241171219296 4765 716894 YLR208W SEC13 SGTC_56 0957-0365 83.25 µM -2.56719764918373 0.011606526507107 no 3310 0.00512620777744017 4731 6752360 SGTC_2175 5807670 165.306 µM -2.58318465399314 0.0111860256931105 no 3311 0.00489464565699381 4757 241186 SGTC_2199 6590217 200 µM -2.58820604269219 0.0110567126240169 no 3312 0.00482386264482599 4781 703109 SGTC_431 k089-0097 107 µM -2.6136327197318 0.0104216848773855 no 3313 0.00447926409549638 4536 5499420 SGTC_2298 7976326 193.81 µM -2.62100141596221 0.0102436977942234 no 3314 0.00438359489114769 4759 2235818 SGTC_865 0488-0499 301 µM -2.62594672081278 0.0101257383753066 no 3315 0.00432041707319229 4747 9634651 SGTC_1948 st076329 66.6 µM -2.62695061214677 0.010101937984222 no 3316 0.00430769187067829 4741 24208413 SGTC_2354 9060492 162 µM -2.62777218474115 0.0100824963652292 no 3317 0.00429730265851862 4764 6471895 SGTC_817 1391-0715 46 µM -2.63554886220663 0.00990008113331412 no 3318 0.00420006653261865 4774 1353946 SGTC_2186 6124449 200 µM -2.63843801073927 0.009833049085763 no 3319 0.00416444631248822 4782 3834182 YLR033W RSC58 SGTC_147 4466-0538 29.23 µM -2.658929095205 0.00936890261935869 no 3320 0.0039194729232104 4753 6742687 YHR072W ERG7 SGTC_1851 st056236 18.9 µM -2.70054268266441 0.00848494116259155 no 3321 0.00346132268379046 4763 5393171 SGTC_1332 1480-0653 17.5 µM -2.77752055949575 0.00704106690814296 no 3322 0.0027387687328966 4785 5749438 SGTC_2361 9034121 116 µM -2.78678267971683 0.00688286016841714 no 3323 0.00266170829594598 4785 6496917 SGTC_813 k007-0158 173 µM -2.83264896928002 0.00614479197966862 no 3324 0.00230820251130533 4781 6523916 SGTC_2848 9016370 25.97 µM -2.86625732741896 0.00564938112410097 no 3325 0.0020767823511848 4751 7894410 SGTC_565 1418-0001 44.5 µM -2.88569845523483 0.00537928921218783 no 3326 0.001952730746358 4789 2862145 SGTC_3297 9117502 71.43 µM -2.93831818479634 0.00470495370659254 no 3327 0.00164999075957949 4783 7453720 SGTC_588 3970-1144 52.9 µM -2.94189155852011 0.00466202032754193 no 3328 0.00163107070109353 4767 1888707 SGTC_2176 5809774 33.9695 µM -2.97422089624616 0.004289198646747 no 3329 0.00146866768477015 4782 2870539 SGTC_1935 st074532 41.6 µM -2.98460135900452 0.00417527523257039 no 3330 0.00141974054562063 4771 2829742 SGTC_2829 7992743 58.44 µM -3.00468633334393 0.00396250475597093 no 3331 0.00132927430259745 4765 16462845 SGTC_2970 9090938 41.86 µM -3.05936786506757 0.00343158728935775 no 3332 0.001109023040951 4795 17217104 SGTC_259 usnic acid 108.925 µM -3.07003092277937 0.00333583417353329 no 3333 0.00107018304519249 4795 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2859 9028643 45.46 µM -3.10171960855759 0.00306528639662587 no 3334 0.000962000512646291 4750 17151580 SGTC_1924 st058459 75.1 µM -3.1530366233772 0.00266884788077315 no 3335 0.000807907667850749 4788 688683 SGTC_2024 5144227 134 µM -3.20548843940659 0.00231206947000612 no 3336 0.000674167314661327 4779 3475211 SGTC_2576 guaiol 23.12 µM -3.22330487388729 0.00220108452843194 no 3337 0.000633603007157581 4776 227829 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -3.24772473659881 0.00205680720123888 no 3338 0.000581658768358839 4785 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -3.27379865128504 0.0019122776583866 no 3339 0.000530560963007357 4779 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_564 3555-0129 330 µM -3.28383998090527 0.00185912458237343 no 3340 0.000512015240062311 4804 563260 SGTC_2430 5571206 200 µM -3.30373615854824 0.00175775355983152 no 3341 0.00047702787847197 4773 1731771 SGTC_2707 st078556 66.6 µM -3.31428395310743 0.00170607701890404 no 3342 0.000459390756484711 4798 17250899 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -3.3955900105518 0.00135187381374289 no 3343 0.000342404264925968 4801 756377 SGTC_138 0850-0259 40.9225 µM -3.4334141011004 0.00121120050218536 no 3344 0.000298015514399838 4773 6813004 SGTC_1556 plumbagin 1.48 µM -3.43528688281412 0.00120459659211201 no 3345 0.000295963418737066 4789 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2708 st078559 56 µM -3.80782850969663 0.000385987397388433 yes 3346 7.0096217859831e-05 4808 17250902 SGTC_1861 st057647 17.4 µM -3.85077125701564 0.000336342863284773 yes 3347 5.88732177024574e-05 4805 688668 SGTC_567 1080-0542 68.4 µM -4.05757666155243 0.000170076357377807 yes 3348 2.47922717403769e-05 4805 5950415 SGTC_3210 9128157 49.47 µM -4.45992904428313 4.1249869849867e-05 yes 3349 4.09933958499723e-06 4795 17590849 SGTC_2566 crystal violet carbinol 226 nM -5.74316193108393 2.01763565158141e-07 yes 3350 4.64623924123392e-09 4802 68050 Cationic dye that binds acidic phospholipids including cardiolipin.