SGTCid condition conc unit BUG1|YDL099W.score BUG1|YDL099W.strain.pval BUG1|YDL099W.strain.significant BUG1|YDL099W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_996 3970-0799 1.8 µM 15.7922600518465 2.35790979910465e-74 yes 1 1.75874005927778e-56 4 6615648 YGL040C HEM2
SGTC_638 3970-0837 4.09 µM 5.24399470630813 7.28312326713121e-10 yes 2 7.85683548994183e-08 16 4118451 YLR208W SEC13
SGTC_1174 0739-0097 51.1 µM 4.15655724358175 8.09613698781979e-07 yes 3 1.61539624431085e-05 23 728447
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 4.14626525839784 8.58911101837451e-07 yes 4 1.68971150683105e-05 20 688761
SGTC_3058 9093861 49.47 µM 3.81645024171151 5.31392162661464e-06 yes 5 6.76926810025893e-05 21 17217477
SGTC_1 0258-0098 57.368 µM 3.76393215806876 7.01258267719599e-06 yes 6 8.3631139415666e-05 10 6790032 YDR047W HEM12
SGTC_159 3970-0959 50 µM 3.68833405373357 1.03896865054899e-05 yes 7 0.000112863585538927 93 6615653
SGTC_1572 epiandrosterone 68.9 µM 3.65535281968757 1.23053882678079e-05 yes 8 0.000128414260115818 37 441302 A steroid.
SGTC_2425 5628681 7.85 µM 3.62119845392318 1.4640958366485e-05 yes 9 0.00014662073029197 36 5714958
SGTC_1376 2910-0861 41.3 µM 3.58691795844518 1.74050547922522e-05 yes 10 0.000167304771788595 30 1112859
SGTC_626 0214-0009 33 µM 3.35929052972434 5.28420972980822e-05 yes 11 0.000390714336658604 39 3437874
SGTC_519 k048-0011 62.8 µM 3.28489510374411 7.48931503176504e-05 yes 12 0.000510101729935252 45 6836379
SGTC_70 0141-0289 43.283 µM 3.27679964869238 7.77572246630854e-05 yes 13 0.000524954203988419 240 352408
SGTC_2925 9010536 32.5 µM 3.19567227214456 0.000112744419662469 yes 14 0.000697527364648861 83 2994177
SGTC_2640 pentamidine 10.38 µM 3.05981811042343 0.000206180172276228 yes 15 0.00110735725079085 64 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_629 3448-6466 76.7 µM 3.05682697693501 0.000208884196607445 yes 16 0.00111846678722722 58 573744
SGTC_2499 avocadenofuran 51.48 µM 3.05602935234107 0.000209610832954321 yes 17 0.00112144648887773 84 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_500 h-89 112 µM 2.89665467365106 0.000412877338074456 yes 18 0.00188582333288585 77 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_452 diindolylmethane 8 µM 2.89248219338575 0.000420091215684187 yes 19 0.00191105423548434 43 3071 Inhibits expression of several cancer promoting factors.
SGTC_2624 nerol 100 µM 2.8342591894868 0.000533740834253277 yes 20 0.00229660306413619 55 637566 A natural product oil.
SGTC_684 1140-0066 328 µM 2.80055454886502 0.000611912726363671 yes 21 0.00255074423207083 110 6813534
SGTC_402 epigallocatechin gallate 10 µM 2.78338967840626 0.000655667500072163 yes 22 0.00268970767537074 102 65064 An antioxidant.
SGTC_2432 5630864 12.22 µM 2.76815571970777 0.000696900108194337 yes 23 0.00281872563301556 102 5714970
SGTC_46 0329-0187a 2.197 µM 2.75703676524695 0.000728490221240462 yes 24 0.0029163896480365 157 46494817
SGTC_2346 9031566 143.75 µM 2.74149929260703 0.000774847463881016 yes 25 0.00305797462254935 75 4771086
SGTC_848 0368-0089 85.6 µM 2.72333512804447 0.000832478776831833 yes 26 0.00323132318891232 77 762535
SGTC_364 0083-0097 67.7 µM 2.71657577907224 0.000854913344860603 yes 27 0.00329805465991385 97 5207356
SGTC_1964 st076914 61 µM 2.66728173995151 0.00103610001052077 no 28 0.00382337694669737 78 24208661
SGTC_548 1436-0017 110 µM 2.63878887078903 0.00115626839183674 no 29 0.00416013902446201 128 9677137
SGTC_1755 st041960 45.185 µM 2.62515361228125 0.00121817773913208 no 30 0.00433049416648207 98 2257073
SGTC_292 k038-0015 474 µM 2.60342452805011 0.00132313034864251 no 31 0.00461487932230474 67 46368540
SGTC_755 1995-0008 37.3 µM 2.60097399176282 0.00133547118972015 no 32 0.00464797506283162 93 689533
SGTC_2125 5246583 200 µM 2.57287240074232 0.00148470540214243 no 33 0.00504291923150191 145 835267
SGTC_1361 1608-0041 5.61 µM 2.57229153293674 0.0014879446564999 no 34 0.00505138893718218 97 X1361
SGTC_1936 st074407 74.3 µM 2.57146148486781 0.00149258467509432 no 35 0.00506351395435268 152 809813
SGTC_404 fumagillin 50 µM 2.56702486507339 0.0015176102565777 no 36 0.0051287628337657 106 12015870 A methionine aminopeptidase binder.
SGTC_2634 4'-methoxyflavone 100 µM 2.55943036807115 0.00156133823530966 no 37 0.00524219285921614 117 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_523 1934-0222 13.7 µM 2.54920853461955 0.00162200776914167 no 38 0.00539838592362016 121 1361595
SGTC_453 enantio-paf c16 10 µM 2.54868929741126 0.00162514616636569 no 39 0.00540642932513577 338 13871343 A lipid and platelet activating factor
SGTC_1377 2944-0135 198 µM 2.54561559530224 0.00164383795989174 no 40 0.00545426199363347 142 1894137
SGTC_2760 etidronate 98.04 µM 2.54506514300616 0.00164720597252022 no 41 0.00546286767866737 118 3305 A chelator and antioxidant.
SGTC_2211 7117706 200 µM 2.51508976828219 0.00184038758428822 no 42 0.00595010395869172 84 822771
SGTC_2239 6685329 187.64 µM 2.47847221816638 0.00210422081028934 no 43 0.00659731931398519 124 805680
SGTC_43 0570-0105 72.5 µM 2.4678132198418 0.00218722292918263 no 44 0.0067970615989768 270 1114046 YDL195W SEC31
SGTC_2305 7443522 69.23 µM 2.46446582448784 0.00221389508281652 no 45 0.00686088242629825 106 5415886
SGTC_642 0335-0876 158 µM 2.42838520351264 0.00252067587097502 no 46 0.00758311276525968 141 6812350
SGTC_957 1187-1561 14.1 µM 2.40207420802668 0.00276808424211743 no 47 0.00815120047030519 147 1538454
SGTC_184 1494-0393 24.714 µM 2.38886183461514 0.00290041075273936 no 48 0.00845032843552262 190 3090647
SGTC_2302 7771753 200 µM 2.38692925307888 0.00292023718238473 no 49 0.00849488019314982 189 2203047
SGTC_581 0958-0271 211 µM 2.38016336028326 0.0029906149934511 no 50 0.00865248227741885 208 4591145
SGTC_3297 9117502 71.43 µM 2.37933541041991 0.00299933133700532 no 51 0.0086719432417973 101 7453720
SGTC_2801 7907800 81.82 µM 2.37933478895376 0.00299933788815412 no 52 0.0086719578637666 164 6620925
SGTC_2089 5281248 129.67 µM 2.33866158244434 0.00345675537821047 no 53 0.00967647745816819 149 2737878
SGTC_20 0481-0013 4.944 µM 2.33847873912682 0.00345894597224983 no 54 0.00968121366170051 149 182045
SGTC_248 streptozotocin 5.23457 mM 2.33084748182714 0.00355149345054535 no 55 0.00988070169298318 144 5300 DNA alkylating agent.
SGTC_1257 0669-0121 16 µM 2.32330788592471 0.00364510644263006 no 56 0.0100813092439966 163 4307855
SGTC_2935 9038016 29.96 µM 2.32200489085389 0.00366150720662055 no 57 0.0101163361399641 152 6463195
SGTC_1407 3909-7909 12.3 µM 2.28921407846404 0.00409665151772216 no 58 0.0110334585023293 138 4411780
SGTC_1447 4239-0816 81.9 µM 2.25474916452857 0.00460336178138998 no 59 0.0120745388858203 174 1341554
SGTC_314 1671-0008 2.74 µM 2.22883074861181 0.00502052300985538 no 60 0.0129125841113786 225 3913060
SGTC_1618 st003135 44.5 µM 2.22558274288756 0.00507510620707951 no 61 0.0130210715862324 133 1270615
SGTC_2398 5228213 48.84 µM 2.21501978125078 0.00525628966625149 no 62 0.0133793533995559 229 80771 YMR134W ERG29
SGTC_2791 5663188 71.43 µM 2.20961956745237 0.00535112254549501 no 63 0.013565788063832 167 54690634
SGTC_2586 curcumin 80 µM 2.20860052156641 0.00536918762538356 no 64 0.013601219523012 244 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_551 k048-0028 34.9 µM 2.18634232881464 0.0057775305245409 no 65 0.0143952847464489 180 6836383
SGTC_2071 5230951 39.92 µM 2.16632529475194 0.00616805188908573 no 66 0.0151431690619254 170 1799272
SGTC_2843 9000894 45.46 µM 2.15633077349307 0.00637165446868751 no 67 0.015528922984286 89 2242070
SGTC_544 k015-0020 52.4 µM 2.15393293291933 0.00642137787655191 no 68 0.0156227159197167 172 3008304
SGTC_1091 telmisartan 47.6 µM 2.15163543018571 0.00646934238827631 no 69 0.0157130396702602 167 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2230 bromochlorosalicylanilide 954.5 nM 2.14908316459205 0.00652299690547453 no 70 0.0158139040266638 87 77254
SGTC_3207 9114163 49.47 µM 2.14234281385974 0.00666659138258171 no 71 0.0160829529981777 231 849233
SGTC_3131 9127911 49.47 µM 2.14156364900989 0.0066833693360738 no 72 0.0161143057604975 185 45595681
SGTC_1563 conessine 56.1 µM 2.11133643955211 0.0073637422840616 no 73 0.017371702029986 215 441082 An anti-amoebic, histamine inhibitor.
SGTC_2965 9082772 38.63 µM 2.10302680637605 0.00756117084650861 no 74 0.0177317131474599 221 16459634
SGTC_2936 9038235 15.59 µM 2.0943923871164 0.00777124009136828 no 75 0.0181125201877893 198 4749415
SGTC_2441 5730946 39.09 µM 2.09385696899009 0.00778443392421853 no 76 0.0181363617509716 205 1774275
SGTC_2955 9076254 12.21 µM 2.09185930235833 0.00783383476763088 no 77 0.0182255518053268 162 16459619
SGTC_569 4130-2812 160 µM 2.08338951888877 0.00804636294962306 no 78 0.0186078664273575 123 743552
SGTC_802 4112-3352 742 µM 2.07898878506739 0.00815877650694054 no 79 0.0188091906377066 210 704594
SGTC_3080 9117754 49.47 µM 2.07358506609236 0.00829869636113958 no 80 0.0190589316652358 212 9550191
SGTC_1433 4060-0023 7.6 µM 2.05883599341623 0.0086913771191608 no 81 0.0197549761771151 194 3840627
SGTC_1424 4048-1941 275 µM 2.0504680867779 0.00892133317357816 no 82 0.0201593874621211 225 X1424
SGTC_1971 st069429 63.5 µM 2.04638005915862 0.0090356008665407 no 83 0.0203594962161664 168 1246522 YGL099W LSG1
SGTC_2397 5161689 200 µM 2.04387133136014 0.00910635722514131 no 84 0.0204831299947391 235 2259942
SGTC_2103 5378138 10 µM 2.01285826208767 0.0100219417380713 no 85 0.0220647712751962 215 244142
SGTC_3264 9137442 49.47 µM 2.00703128865694 0.0102026600488713 no 86 0.0223731657651055 167 17015726
SGTC_1273 0849-0096 14.1 µM 2.0037210942626 0.0103065835546465 no 87 0.022549972670609 213 5286025
SGTC_2237 6667747 47.222 µM 1.96007216079788 0.0117657142396883 no 88 0.0249936783012641 197 729940 YDL015C TSC13
SGTC_45 0kpi-0036 14.9 µM 1.95993424008299 0.0117705952309189 no 89 0.0250017384675434 216 2795021
SGTC_2084 5306078 60.6385 µM 1.95333830253545 0.0120060850649725 no 90 0.0253897608638324 235 679340
SGTC_1311 1190-0148 100 µM 1.95268331112608 0.012029691219388 no 91 0.0254285662102497 276 1961333
SGTC_103 0844-0104 51.839 µM 1.94932632682645 0.0121513110367927 no 92 0.025628233254955 404 5375804
SGTC_3181 9108277 49.47 µM 1.94512044652166 0.0123051883837291 no 93 0.0258802417917917 220 17097298
SGTC_1079 idarubicin 2.36 µM 1.94221706018453 0.0124123947745051 no 94 0.0260554143207968 206 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_163 TUB2.036 7.546 µM 1.93924061221953 0.0125231377247125 no 95 0.0262360232696873 421 15992207 YJR013W GPI14
SGTC_2340 7987427 183.45 µM 1.93801442388292 0.0125690079910404 no 96 0.0263107314082516 237 2239331
SGTC_2243 6634756 200 µM 1.92397103601 0.0131048132916657 no 97 0.0271791070411412 202 885676
SGTC_3018 9082602 49.47 µM 1.92273902727434 0.0131527471220352 no 98 0.0272564164435378 251 17332089
SGTC_1483 3453-0561 55.9 µM 1.92033713122757 0.0132466335747863 no 99 0.0274076645447537 266 4546991
SGTC_1961 st076550 68.7 µM 1.91719386499849 0.0133703732548233 no 100 0.0276066535933433 206 1579337
SGTC_998 3996-0085 177 µM 1.89943988645303 0.0140881911827625 no 101 0.02875333168396 270 715391
SGTC_1022 4477-0945 21.3 µM 1.88661547287882 0.014627139846166 no 102 0.0296060320514823 269 4648966
SGTC_1418 3966-3099 2.4 µM 1.88610396399423 0.0146489990930388 no 103 0.0296404731286568 269 740335
SGTC_1898 st060199 18.6 µM 1.88494566441528 0.0146986027420253 no 104 0.0297185870292521 225 688866
SGTC_891 0929-0073 133 µM 1.87920219821134 0.0149467041277814 no 105 0.0301084448049267 228 5603632
SGTC_2119 5528445 120.635 µM 1.85370632497481 0.01609197973821 no 106 0.0318905931693158 249 791935
SGTC_1421 4029-0249 71.4 µM 1.85215694649149 0.0161639387166886 no 107 0.0320016445560605 281 2894095
SGTC_550 4123-0385 25.7 µM 1.84847820096057 0.0163358987602844 no 108 0.0322665975307799 259 5731123
SGTC_2308 7584454 197.62 µM 1.84014849450596 0.016731062593053 no 109 0.0328732196398721 308 893577
SGTC_2648 atorvastatin 78.68 µM 1.83772058791181 0.0168477712707544 no 110 0.0330517942699468 223 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_23 0213-0011 39.996 µM 1.83614028749583 0.0169241092905889 no 111 0.0331684556139589 265 627608
SGTC_1125 tnp00248 1.32998 µM 1.83366506023885 0.0170442720137672 no 112 0.033351864067371 377 24207736
SGTC_1434 4073-0095 163 µM 1.82995703901506 0.0172256463134637 no 113 0.0336281815781666 252 24133745
SGTC_457 grayanotoxin iii 135 µM 1.82428840549016 0.0175061084322045 no 114 0.034054241178476 383 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_149 3970-0822 46.1 µM 1.81989168844357 0.0177263170412623 no 115 0.034387750455286 446 3114250 YBL034C STU1
SGTC_3055 9094636 49.47 µM 1.81918965887007 0.0177616959496717 no 116 0.0344412499876672 244 25236176
SGTC_1220 1838-0075 193 µM 1.81883798784331 0.0177794411109364 no 117 0.0344680754624988 286 5529645
SGTC_253 dyclonine 31.25 µM 1.8147214278471 0.0179882881019098 no 118 0.0347833651878298 324 3180 An oral anasthetic.
SGTC_1500 4488-1866 171 µM 1.81280055893459 0.0180864538165746 no 119 0.0349312938683873 289 2900003
SGTC_137 0438-0332 85.389 µM 1.80702120754434 0.0183845650268451 no 120 0.0353794862979695 451 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2708 st078559 56 µM 1.80529115874541 0.0184746145812559 no 121 0.0355145662127358 174 17250902
SGTC_1191 1487-1166 10.6 µM 1.79773651759198 0.0188722498293184 no 122 0.0361093857897445 344 3955771
SGTC_543 3844-1095 191 µM 1.7952422450587 0.0190051235237066 no 123 0.0363075562144713 331 4230703
SGTC_3014 9081533 49.47 µM 1.79108127837012 0.0192285551918397 no 124 0.0366401264978999 268 21367265
SGTC_2368 9071271 200 µM 1.77279963746018 0.0202368613849532 no 125 0.0381309567611252 313 27209959
SGTC_1658 st012944 20 µM 1.77243368280336 0.0202574944376201 no 126 0.0381612973385076 325 24207260
SGTC_2797 7859098 81.82 µM 1.77127174631371 0.0203231243485643 no 127 0.0382577617209113 319 972681
SGTC_3257 9139206 32.98 µM 1.76693194527212 0.0205698462556726 no 128 0.0386198131426641 198 4910041
SGTC_390 dec-rvkr-cmk 16.7 µM 1.76681223773969 0.0205766875487745 no 129 0.0386298392709328 311 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_81 0411-0046 9.971 µM 1.76344004058311 0.0207702022839459 no 130 0.0389131508028883 265 12925265
SGTC_992 3909-8734 162 µM 1.76277798899832 0.0208083747656892 no 131 0.0389689705826077 282 4288319
SGTC_196 k015-0023 18.111 µM 1.75926989079188 0.0210116368581955 no 132 0.0392658390689793 312 5211998
SGTC_1720 st037298 9.481 µM 1.7591717581211 0.0210173468189206 no 133 0.0392741698137438 301 597396
SGTC_2247 cerulenin 830 nM 1.75793131741192 0.0210896365422259 no 134 0.0393795981928703 305 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1272 0839-0021 27 µM 1.7575979381023 0.0211091008678662 no 135 0.0394079722186899 309 5027250
SGTC_2093 5331342 194.4 µM 1.75496054915511 0.0212636209931663 no 136 0.0396330280142448 305 33839
SGTC_658 3253-0951 102 µM 1.75216631975318 0.0214283726734292 no 137 0.0398726065848783 403 1184878
SGTC_401 neomycin 50 µM 1.74340016669933 0.0219522569399315 no 138 0.0406318696061464 265 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_180 1486-1293 102.781 µM 1.73857160595297 0.0222454129668068 no 139 0.0410550722939992 305 4140536
SGTC_1834 st055981 52.8 µM 1.72896686299152 0.022838371841329 no 140 0.0419075129644482 320 471719 YDL150W RPC53
SGTC_1506 4226-2149 212 µM 1.72838730631582 0.0228745734278653 no 141 0.0419594048651494 370 991114
SGTC_2207 7258803 200 µM 1.72821506367408 0.0228853417539537 no 142 0.0419748370177904 252 3666799
SGTC_1824 st053723 68.6 µM 1.72570930409553 0.0230424813148052 no 143 0.0421998616754205 326 675225
SGTC_587 k089-0003 57 µM 1.72297675551808 0.023214877893749 no 144 0.0424463642988324 181 9659696
SGTC_1675 st018485 24.5 µM 1.72059872561723 0.0233657902847963 no 145 0.042661832441557 326 3323024
SGTC_554 4483-2211 187 µM 1.7194024940494 0.0234420160197172 no 146 0.0427705542136161 320 747107
SGTC_621 3584-0052 32.1 µM 1.71611634390197 0.0236524921781282 no 147 0.0430703752119614 324 2273927
SGTC_1089 terbinafine 2.25 µM 1.71500775813571 0.0237238540481564 no 148 0.0431719022744417 296 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_646 4092-0839 27.3 µM 1.71121012850348 0.023969688771117 no 149 0.0435211648041937 314 877796
SGTC_2404 5161160 200 µM 1.70996830894237 0.0240505394048426 no 150 0.0436358667311519 360 2831543
SGTC_2284 7945075 39.21 µM 1.70677561628958 0.0242594571405227 no 151 0.0439318831233466 362 1245402
SGTC_2099 5377090 177.372 µM 1.70641672030412 0.0242830369422833 no 152 0.0439652598499448 339 2243829
SGTC_2522 biochanin a 4.94 µM 1.70512645439836 0.0243679676502733 no 153 0.0440854213713897 288 5280373 A possible chelator.
SGTC_756 0508-1999 28.3 µM 1.69485118797278 0.025053270235618 no 154 0.045051827098619 322 6753853
SGTC_1935 st074532 41.6 µM 1.69444960532731 0.0250803783142214 no 155 0.0450899400764606 398 2829742
SGTC_212 3807-4682 38.772 µM 1.69269596031457 0.025199043081511 no 156 0.0452566773041023 461 3125501 YBL034C STU1
SGTC_616 4092-0450 108 µM 1.69064647474831 0.0253383225278144 no 157 0.0454521713915773 355 787165
SGTC_3309 9129340 25.759 µM 1.68879026486489 0.0254650232892954 no 158 0.0456298150525553 336 17158987
SGTC_2948 9070189 9.45 µM 1.67821801644626 0.0261968193940086 no 159 0.0466522729247699 302 6473636 YDL196W YDL196W
SGTC_1648 st011736 69.8 µM 1.67803604286789 0.0262095676905728 no 160 0.0466700314875222 312 2855514
SGTC_73 0327-0325 16.231 µM 1.67768840562488 0.0262339361001226 no 161 0.0467039720280314 402 53298
SGTC_1775 st081588 35.1725 µM 1.67393973565077 0.0264979129812391 no 162 0.0470712219154253 367 1426443 YGL099W LSG1
SGTC_2788 5282734 71.43 µM 1.66982495032052 0.0267902227763913 no 163 0.0474770012061963 394 743706
SGTC_2208 7283366 200 µM 1.66895094276681 0.0268526567754131 no 164 0.0475635512237072 318 898663
SGTC_119 0121-0043 24.815 µM 1.66636316077423 0.0270382255280097 no 165 0.0478205518076079 542 1092378
SGTC_1633 st005664 67.9 µM 1.6649146417616 0.0271425646002842 no 166 0.0479648933177618 366 2063822
SGTC_1531 st059297 52.4 µM 1.6589941429702 0.0275725262873699 no 167 0.0485584862699759 347 7566702
SGTC_1708 st033234 31.827 µM 1.65792959675881 0.0276504354111507 no 168 0.0486658387425946 349 674664
SGTC_1825 st052143 62.6 µM 1.65512045117423 0.0278569048466096 no 169 0.0489500335988317 287 674173
SGTC_1217 1183-1422 255 µM 1.65415448424768 0.0279281985666077 no 170 0.0490480640891208 327 2849664
SGTC_3214 9129694 49.47 µM 1.64478026584521 0.0286279939885003 no 171 0.0500075666011812 336 17158655
SGTC_1491 4138-0063 26.5 µM 1.64242980303814 0.0288057272404603 no 172 0.0502504813686768 292 23883227
SGTC_2270 7924575 90.91 µM 1.64131532980392 0.0288903196197916 no 173 0.0503659877674375 350 1262135
SGTC_2828 7998861 71.43 µM 1.63742094218363 0.0291875401660242 no 174 0.0507712726827916 275 2988188
SGTC_3149 9097855 49.47 µM 1.63711196147086 0.029211230009755 no 175 0.0508035388624762 325 25236625 YMR079W SEC14
SGTC_1284 0929-0043 16 µM 1.61471995050732 0.03097105360456 no 176 0.0531856775611144 391 1239883
SGTC_3343 9148379 18.9835 µM 1.60880127407367 0.0314505998729736 no 177 0.0538299011095293 354 1955036
SGTC_1196 1588-0294 184 µM 1.60741340608563 0.0315639325405097 no 178 0.0539818555910825 333 6144269
SGTC_3017 9080681 49.47 µM 1.60362714895714 0.0318748341449427 no 179 0.0543981313711583 339 16451914
SGTC_1604 st002052 72.4 µM 1.60010699320856 0.0321661501944341 no 180 0.0547874249393418 377 6254834 YHR062C RPP1
SGTC_1215 3852-0577 11.2 µM 1.5990376405087 0.0322550801757539 no 181 0.0549061196254995 403 2884876
SGTC_143 4032-1194 15.74 µM 1.5988379321427 0.0322717108776274 no 182 0.0549283091116417 463 1806963
SGTC_2446 5162541 200 µM 1.59174871340167 0.0328666649587356 no 183 0.0557205890056714 353 1549321
SGTC_1041 0206-0046 107 µM 1.58179529643158 0.0337172243885359 no 184 0.0568481545699286 370 50494
SGTC_934 2950-0684 338 µM 1.58160421275968 0.0337337287986912 no 185 0.0568699758537837 403 1121253
SGTC_1978 st071761 42 µM 1.57829229689366 0.0340208454926471 no 186 0.0572492373834782 351 5147680
SGTC_2422 chlorphenesin carbamate 384.24 µM 1.5782840334923 0.0340215643690681 no 187 0.057250186143858 456 2724 A muscle relaxant with antifungal properties.
SGTC_408 cantharidin 100 µM 1.57691973352075 0.0341404233415785 no 188 0.057406997646758 417 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1292 0kpi-0043 232 µM 1.56892539293334 0.0348437763904401 no 189 0.0583326621309468 377 3333905
SGTC_3004 9076122 71.4286 µM 1.5598525135994 0.0356563873162014 no 190 0.0593973691937814 404 44782551
SGTC_3011 9081274 71.4286 µM 1.55472621010565 0.0361223498060176 no 191 0.0600056447890231 409 6625322
SGTC_1837 st055472 66.5 µM 1.5546097640536 0.0361329919766408 no 192 0.0600195184657749 387 676091
SGTC_759 3486-0358 89.3 µM 1.55375174776482 0.0362114864850737 no 193 0.0601218221496777 427 875103
SGTC_2644 guaiazulene 100 µM 1.55128713880008 0.036437734791074 no 194 0.0604164437881724 349 3515 A coloring agent.
SGTC_3091 9116372 49.47 µM 1.55083630389026 0.0364792458213085 no 195 0.0604704590409682 368 17169793
SGTC_577 r071-0003 38.6 µM 1.54852905634882 0.0366922939055644 no 196 0.0607474858058651 532 4568517 YMR134W ERG29
SGTC_2297 7971671 152.32 µM 1.53961624302083 0.0375248697940997 no 197 0.0618269618894286 381 909016
SGTC_3010 9080089 71.4286 µM 1.53794118084761 0.0376830521414433 no 198 0.0620314985495413 370 17027233
SGTC_1812 st052057 4.327 µM 1.53282206100636 0.0381698461439672 no 199 0.0626598517221953 410 3645418
SGTC_2752 diclazuril 33.15 µM 1.53140022190534 0.0383059598461987 no 200 0.0628352546478304 578 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_738 1315-0003 72.4 µM 1.52748110077473 0.0386831899800822 no 201 0.0633207116218667 418 6251474
SGTC_1295 1013-0063 9.78 µM 1.52100189299969 0.0393134717745437 no 202 0.0641296811384699 416 6826038
SGTC_27 0485-0001 32.618 µM 1.51960434540931 0.0394505116289909 no 203 0.0643052225616847 287 2054479
SGTC_1001 4048-4355 44.4 µM 1.51898900785582 0.0395109731125576 no 204 0.0643826314241606 398 21824233
SGTC_1663 st014140 55.4 µM 1.51853910941968 0.0395552266568647 no 205 0.0644392740158034 463 4207120
SGTC_1699 st031318 29.054 µM 1.51391347731525 0.0400125615461659 no 206 0.0650238927219201 410 5340658
SGTC_1352 1496-0991 99 µM 1.51370705455011 0.0400330702412071 no 207 0.0650500774680447 399 3000039
SGTC_2076 5212012 200 µM 1.51354601749533 0.040049075665881 no 208 0.0650705107147615 303 604802
SGTC_1205 4161-2785 76 µM 1.51340221725041 0.0400633723233584 no 209 0.0650887610721804 382 3498106
SGTC_1456 k015-0012 13 µM 1.51178475031031 0.0402244671212271 no 210 0.0652943150511606 460 2989616
SGTC_2407 paclitaxel 400 µM 1.50803329645692 0.0406001263358809 no 211 0.0657730027149794 454 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2639 lactacystin 53 µM 1.49769942860955 0.0416496722334609 no 212 0.0671056801887913 459 3870 A proteasome inhibitor.
SGTC_3291 9121177 71.43 µM 1.49657306332522 0.0417653865039744 no 213 0.0672521917333554 352 17015612
SGTC_2769 toremifene 3.73 µM 1.49637823655967 0.041785427922889 no 214 0.0672775588208339 399 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3341 9147222 25.867 µM 1.48506302670894 0.0429628255105735 no 215 0.0687635645645088 408 1939759
SGTC_366 0181-0206 4.31 µM 1.48247109093401 0.043236266851279 no 216 0.0691074951118383 462 274874
SGTC_695 3505-6186 243 µM 1.47986425856361 0.0435126956317384 no 217 0.0694547378526185 433 1819379
SGTC_1234 0326-0494 15.5 µM 1.47697475657188 0.0438207638147134 no 218 0.0698412020396954 418 1547813
SGTC_339 3091-4833 71.4 µM 1.47554781384049 0.0439735469519998 no 219 0.0700326617430735 411 3240077
SGTC_1161 k007-0610 110 µM 1.47548211000092 0.0439805922121161 no 220 0.0700414872551802 552 5843850
SGTC_1106 tegaserod maleate 11.7 µM 1.47464999952636 0.0440698961474457 no 221 0.070153332568065 459 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_188 3229-0966 278.469 µM 1.47317730305211 0.0442283075197855 no 222 0.0703516167338765 515 5722370
SGTC_938 3126-1755 342 µM 1.47086621818966 0.0444778255766093 no 223 0.0706636500689539 454 1777771
SGTC_2918 7977171 22.06 µM 1.4648228566553 0.0451356649050914 no 224 0.0714846270835987 413 2236483
SGTC_132 0417-1715 25.805 µM 1.45365354907808 0.0463720720048477 no 225 0.073021191295295 466 6769098
SGTC_2736 butenafine 14.65 µM 1.45281871068017 0.0464655675644719 no 226 0.0731370477592441 497 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2891 9063876 19.48 µM 1.45016385951347 0.0467638967674884 no 227 0.0735064152989388 345 6472478
SGTC_1162 k048-0130 20.1 µM 1.44549246625708 0.0472925564821294 no 228 0.074159803810788 441 6797406
SGTC_389 tpck 16.7 µM 1.4432245418185 0.04755093817653 no 229 0.0744786141262182 443 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_385 1494-0393 12.4 µM 1.44018051077122 0.0478995168158145 no 230 0.0749081678054915 461 3090647
SGTC_1413 3910-0535 34.4 µM 1.43333679869664 0.04869067522886 no 231 0.0758808052456341 462 2876951
SGTC_1806 st050005 60.3 µM 1.4273268786932 0.0493940271172926 no 232 0.0767428482627191 466 5194765
SGTC_669 0108-0021 26.2 µM 1.42650448813245 0.0494909007307599 no 233 0.0768613861613539 586 17201
SGTC_367 0335-0881 7.1 µM 1.42464721676056 0.0497102362465374 no 234 0.0771296020054728 502 23828853
SGTC_734 2023-0417 80 µM 1.42144013674555 0.0500908033839395 no 235 0.0775944225487255 483 3935732
SGTC_1014 4130-3005 69.3 µM 1.41846184887371 0.0504462978122715 no 236 0.0780279847647413 502 743608
SGTC_2533 agelasine 13.65 µM 1.41801398510117 0.0504999291798477 no 237 0.078093340891436 512 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1989 st071868 50.2 µM 1.41476839333057 0.0508899450721247 no 238 0.0785682069984366 483 16414057
SGTC_2439 5492030 7.2 µM 1.41331793661269 0.0510650169220618 no 239 0.0787811312086667 445 5722370
SGTC_831 k061-1017 217 µM 1.41251543130248 0.0511620860384655 no 240 0.0788991251392837 636 1240153
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.40999966942827 0.0514673384267585 no 241 0.0792698902585193 411 279621
SGTC_1379 2144-0755 36.5 µM 1.4083952038877 0.0516627730378052 no 242 0.0795070393089849 518 5392327
SGTC_2065 5221596 34.26 µM 1.40586616030453 0.0519720248168252 no 243 0.0798819357496514 476 788581
SGTC_1550 gossypolone 36.6 µM 1.40193810241917 0.0524552625723675 no 244 0.0804668655845858 488 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2320 7373003 200 µM 1.39230438766973 0.0536555273779259 no 245 0.0819151217097255 465 5415828
SGTC_2260 7964312 200 µM 1.39056788783899 0.0538741741567204 no 246 0.0821782498388149 439 231951
SGTC_2460 5552655 174.22 µM 1.3854770884227 0.0545192361247989 no 247 0.0829533167844319 482 5401989
SGTC_1688 st021091 57.6 µM 1.38461750105685 0.0546287559020271 no 248 0.0830847285914674 456 3656366
SGTC_2030 5175110 200 µM 1.37087798154495 0.0564030204241941 no 249 0.0852064981295616 487 2831986
SGTC_1346 1488-2224 62.4 µM 1.36761787616716 0.0568306131443174 no 250 0.0857158589809477 518 3722427
SGTC_285 1486-1325 46 µM 1.36062991304109 0.0577557474050787 no 251 0.0868153367744221 536 22310230
SGTC_3124 9127567 49.47 µM 1.3576471802473 0.0581542186122459 no 252 0.0872878322590524 471 17592030
SGTC_344 k064-0035 6.43 µM 1.3510758065157 0.0590397259911844 no 253 0.0883355752757539 493 5088750
SGTC_225 nsc-122657 1.016 µM 1.34960701539825 0.0592390878482328 no 254 0.0885710363359037 365 275685
SGTC_3084 9116877 49.47 µM 1.34754462528929 0.0595199106146596 no 255 0.0889024456058119 422 27241325
SGTC_2997 9067075 71.4286 µM 1.34694824986218 0.0596013095105344 no 256 0.0889984501357394 559 27209819
SGTC_1932 st074806 40.9 µM 1.34066966072094 0.0604635729126765 no 257 0.0900138645635466 563 17251235
SGTC_1194 1488-0194 225 µM 1.33519195985699 0.0612237926245752 no 258 0.0909067638286782 567 1391452
SGTC_977 1348-1378 135 µM 1.33511415708644 0.0612346439886065 no 259 0.090919493322688 543 X977
SGTC_2968 9090663 33.37 µM 1.33335809218714 0.0614799671168264 no 260 0.0912071590914315 517 25236811
SGTC_191 3914-0123 66.505 µM 1.33182085487987 0.0616953494377448 no 261 0.0914595316287904 373 3144412
SGTC_2395 5646831 180.19 µM 1.33161397552327 0.0617243802254659 no 262 0.0914935350667568 520 6808628
SGTC_1988 st071872 53.4 µM 1.32969124259107 0.0619947022429524 no 263 0.0918100107022767 490 16414116
SGTC_2671 danthron 100 µM 1.32937699395178 0.0620389709753036 no 264 0.0918618120155427 516 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1733 st037357 54.9 µM 1.32183872977632 0.0631083083638408 no 265 0.0931109292608201 559 1272339 YGL099W LSG1
SGTC_1706 st031321 9.9705 µM 1.31868270321189 0.0635602457295025 no 266 0.0936376058590022 517 6103185
SGTC_1309 pyrazolanthrone 13.4 µM 1.31300929483198 0.0643789959652038 no 267 0.0945899080791282 570 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_574 1315-0397 40 µM 1.31298399235624 0.0643826657272748 no 268 0.0945941711238143 620 6794277
SGTC_864 0469-0573 172 µM 1.31157426010013 0.064587384147834 no 269 0.0948319112927347 524 689425
SGTC_2090 5301565 104.445 µM 1.30935277505269 0.0649110093660366 no 270 0.0952074402145417 602 2056344
SGTC_2037 5169046 200 µM 1.3016122421658 0.0660484894766169 no 271 0.0965244863706568 512 5718022
SGTC_1724 st037281 8.293 µM 1.29986763656017 0.0663069813440984 no 272 0.0968231694735323 562 574124 YDL195W SEC31
SGTC_1697 st025554 27.742 µM 1.29924100078743 0.0664000186842595 no 273 0.0969306173899378 510 1269519
SGTC_885 0865-0106 16.8 µM 1.29325055886046 0.0672945354498828 no 274 0.0979622071925252 548 2793380
SGTC_1972 st070201 17.4 µM 1.29049698121272 0.0677088232037666 no 275 0.0984390796484939 565 2829099
SGTC_2151 5563267 85.4165 µM 1.29028367048403 0.0677409987776269 no 276 0.098476092226254 573 5310824
SGTC_1630 st005209 31.3 µM 1.28776334507706 0.0681220568327273 no 277 0.0989141777460578 619 3367314
SGTC_432 NS 1619 61.3 µM 1.28494984289222 0.0685493937199078 no 278 0.0994049059187504 508 4552 A K+/calcium channel activator.
SGTC_2616 abietic acid 100 µM 1.2847175348241 0.0685847707104037 no 279 0.0994455042528964 583 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_3007 9078383 71.4286 µM 1.28398101907135 0.0686970239739532 no 280 0.0995742984260576 556 6496995
SGTC_1047 2043-3044 82 µM 1.28340749295072 0.0687845338673266 no 281 0.0996746750635366 566 669592
SGTC_2341 7987486 176.74 µM 1.28072305220391 0.0691952748952544 no 282 0.100145479912986 595 1258686
SGTC_2453 5731132 22.18 µM 1.27789734879037 0.0696296690971709 no 283 0.100642811505897 598 1362040
SGTC_3354 9151612 71.43 µM 1.27778078427838 0.069647633499143 no 284 0.100663365802466 599 27261949
SGTC_978 1416-0512 87.4 µM 1.2766779814358 0.069817769162091 no 285 0.100857979062488 609 6814003
SGTC_674 0498-0004 451 µM 1.27474096032769 0.0701173785198841 no 286 0.101200471918287 555 4231473
SGTC_2804 7954240 19.48 µM 1.27465456893217 0.0701307641396547 no 287 0.101215766862855 600 828705
SGTC_511 blebbistatin 171 µM 1.27453218314894 0.0701497301514984 no 288 0.101237437225349 550 3476986 A myosin inhibitor.
SGTC_811 0416-0114 265 µM 1.27383125686201 0.0702584280618221 no 289 0.101361612575287 537 6612453
SGTC_2025 5147754 141 µM 1.27011084075746 0.0708375505967525 no 290 0.102022575299825 534 315777 YLR208W SEC13
SGTC_2396 5342950 42.78 µM 1.26783655354656 0.0711933696405425 no 291 0.102428162723344 612 1886677
SGTC_2309 7664088 163.95 µM 1.26750880646739 0.0712447595821061 no 292 0.102486708366126 629 704922
SGTC_398 bronopol 33.3 µM 1.26713222395176 0.0713038419554898 no 293 0.102554007543581 568 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1709 st033179 39.1045 µM 1.26683945985615 0.0713497999611365 no 294 0.102606349697957 588 573381
SGTC_3150 9097574 49.47 µM 1.26301438919495 0.0719523493080098 no 295 0.103292004289471 537 17217476
SGTC_790 1575-0012 79.1 µM 1.26063066599668 0.0723298171460734 no 296 0.103720972354114 589 378741 YLR208W SEC13
SGTC_257 daunorubicin 18.5 µM 1.260615393554 0.0723322404537641 no 297 0.103723724900185 537 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_963 1269-2853 151 µM 1.25947372982117 0.0725135666276886 no 298 0.103929636560262 550 3668223
SGTC_493 zm226600 134 µM 1.25913881649952 0.0725668256573961 no 299 0.103990098077366 583 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1070 indatraline 8.81 µM 1.25704150622791 0.0729010284471284 no 300 0.10436930314195 589 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2232 chlorophetanol 41.5365 µM 1.25659734971331 0.072971954968136 no 301 0.104449737461483 727 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2839 9003951 25.97 µM 1.25602269038418 0.0730637995995699 no 302 0.104553871763923 536 2990634
SGTC_1370 2001-0092 44.6 µM 1.25407737031005 0.0733753660659691 no 303 0.104906942376725 663 790957
SGTC_1182 1222-0449 220 µM 1.25109567854914 0.0738548910914472 no 304 0.105449786004634 549 658318
SGTC_2009 4012297 12.05 µM 1.24924144375779 0.0741543004681361 no 305 0.105788388964222 558 45595307
SGTC_1097 itavastatin 7.23 µM 1.24794954061547 0.074363455714835 no 306 0.106024768299715 594 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.24488385378634 0.0748615836444677 no 307 0.10658722339659 564 616764
SGTC_946 3434-1334 87.4 µM 1.23968531849019 0.0757120797357233 no 308 0.107545904772152 570 4047976
SGTC_3200 9114385 49.47 µM 1.23867774422209 0.0758777701722354 no 309 0.107732431970101 551 17018030 YLR208W SEC13
SGTC_1654 st012436 41.8 µM 1.23476519047307 0.076523788435747 no 310 0.108458952966349 542 4323132
SGTC_1553 gossypol 38.6 µM 1.23251357794593 0.076897453635486 no 311 0.108878648877984 461 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1100 amiodarone 5.07 µM 1.23248073710374 0.076902913965098 no 312 0.108884778970086 625 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_425 3825-7017 13.1 µM 1.22922811909289 0.0774451766352113 no 313 0.109493144483723 647 3397440
SGTC_2388 9080168 200 µM 1.22886500962701 0.0775058924412661 no 314 0.109561211182488 557 15943073
SGTC_3128 9127691 49.47 µM 1.22652275922096 0.0778984108038054 no 315 0.110001008027325 492 41316314
SGTC_774 k060-0086 136 µM 1.22456860358979 0.0782270443391148 no 316 0.110368901682155 683 5911235
SGTC_2470 5664817 21.68 µM 1.224303787939 0.0782716596004398 no 317 0.110418824261685 588 2859561
SGTC_1460 k062-0059 9.15 µM 1.22131750923884 0.0787761145024355 no 318 0.110982913249597 587 1373085
SGTC_2863 9028737 58.44 µM 1.21896243745051 0.0791756776650162 no 319 0.111429224817924 560 6460917
SGTC_19 0279-0214 38.434 µM 1.21895319886279 0.0791772481064548 no 320 0.111430978155951 708 3566274 YBR002C RER2
SGTC_1327 1436-0082 2.18 µM 1.2178200351903 0.0793700503152689 no 321 0.111646184482955 594 15992205
SGTC_2978 9011784 42.97 µM 1.21519372080849 0.0798182707539755 no 322 0.112146107379286 713 2994934
SGTC_897 1000-0139 31.4 µM 1.21140204380319 0.0804687515582816 no 323 0.112870678234539 609 6151020
SGTC_668 1682-0499 62.6 µM 1.21041057952222 0.0806395008431298 no 324 0.113060692159768 655 682214
SGTC_1149 3909-7961 23.3 µM 1.20817312708908 0.0810258387096487 no 325 0.113490338051148 604 735261
SGTC_335 4077-0256 27.6 µM 1.2071233365774 0.0812075853817667 no 326 0.113692324431773 695 3121989
SGTC_2050 5263056 171 µM 1.20497228740466 0.0815809498241231 no 327 0.114107000178416 701 763468 YGL055W OLE1
SGTC_3295 9122362 53.5725 µM 1.19917904460327 0.0825929374218026 no 328 0.115229166844473 587 4730473
SGTC_2266 7929956 200 µM 1.19479575076096 0.0833648871216812 no 329 0.116083420472221 644 2967153
SGTC_156 3474-0145 5.642 µM 1.19402857635355 0.0835005514513016 no 330 0.116233394995311 633 2265471
SGTC_798 1287-0182 476 µM 1.19044425878424 0.0841365882094563 no 331 0.116935913141942 689 1649755
SGTC_1828 st055811 49 µM 1.18970401842839 0.0842683957064489 no 332 0.117081372713206 572 5877589
SGTC_1569 carminic acid 40.6 µM 1.18909253841617 0.0843773929162671 no 333 0.117201627126464 654 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2387 9077560 195.08 µM 1.18451609779332 0.0851965110633405 no 334 0.118104413902333 638 5303272
SGTC_2974 9094440 9.66 µM 1.18451471434152 0.085196759579313 no 335 0.118104687555106 657 25236134
SGTC_582 0987-0078 156 µM 1.18308803071247 0.0854533306986359 no 336 0.118387130494402 768 1625765
SGTC_770 0389-1121 67.2 µM 1.18229223309714 0.0855966960944564 no 337 0.118544883160916 686 6753108
SGTC_2064 5220758 200 µM 1.17829209290803 0.0863200625662248 no 338 0.119340089494925 686 788518
SGTC_601 0986-0029 62.9 µM 1.17808185665823 0.0863582067619274 no 339 0.11938198720156 663 24747981
SGTC_114 0364-0001 490.298 µM 1.17496210803963 0.0869257202498756 no 340 0.120004937876202 646 4003655
SGTC_1204 4049-0315 18.3 µM 1.17485311576327 0.0869455972841296 no 341 0.120026742772369 630 588402
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.17447696683548 0.0870142220329674 no 342 0.120102016234106 698 16486 A toxic proline analog.
SGTC_920 mycophenolic acid 780.421 nM 1.17079044218609 0.0876889355135202 no 343 0.120841510287336 641 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2917 7979103 53.79 µM 1.16866340639192 0.0880800005018274 no 344 0.1212696354723 706 2980565
SGTC_252 miconazole 1.30953 nM 1.16734554595477 0.0883229465171691 no 345 0.121535426153058 631 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1160 4092-0570 10.5 µM 1.1665245970106 0.0884745397190319 no 346 0.121701204836506 676 4994975
SGTC_83 0170-0301 39.027 µM 1.16581146020271 0.0886063820193382 no 347 0.121845341343731 544 3089716
SGTC_994 3910-0338 138 µM 1.16565128179199 0.0886360153739807 no 348 0.121877732483243 671 3479481
SGTC_847 0342-0274 5.54 µM 1.1648586418745 0.088782764134669 no 349 0.122038108466728 667 18097
SGTC_696 1560-0013 611 µM 1.16424805392592 0.088895931235253 no 350 0.12216175062403 665 1650269
SGTC_258 haloperidol 50.781 µM 1.16392448658305 0.0889559451109292 no 351 0.122227307644663 633 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_737 1950-0117 57.9 µM 1.16311332236099 0.0891065289271289 no 352 0.122391763780446 648 5393513
SGTC_1616 st002734 56.1 µM 1.16082895006824 0.0895316171009164 no 353 0.122855733662178 686 4026101
SGTC_3224 9130643 49.47 µM 1.16022263673652 0.0896446959713492 no 354 0.122979086434135 627 17644395
SGTC_2874 9043904 71.43 µM 1.15996258338254 0.0896932290644342 no 355 0.123032020169406 544 4463428
SGTC_932 2857-0803 154 µM 1.15803286722465 0.0900539775204998 no 356 0.123425311980837 697 674898
SGTC_1743 st037606 46.3785 µM 1.15794441687204 0.0900705385665104 no 357 0.123443359965517 646 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_284 0988-0104 32.6 µM 1.15571132885423 0.0904894019761672 no 358 0.123899626361781 675 4666532
SGTC_3305 9127027 53.8275 µM 1.15475588321757 0.0906690573328068 no 359 0.124095203917293 653 41905295
SGTC_318 1488-0629 67.2 µM 1.15240802592978 0.0911116564468082 no 360 0.124576722237436 621 3662576
SGTC_2840 9008771 71.43 µM 1.14956080837476 0.0916505382369186 no 361 0.125162403963309 610 2992978
SGTC_2226 7298446 200 µM 1.14853726556048 0.0918448361578819 no 362 0.125373419100591 614 3283010
SGTC_1030 k029-0042 36.7 µM 1.14785396134936 0.0919747167080869 no 363 0.125514428289002 714 6080581
SGTC_2380 9035439 200 µM 1.14699480663607 0.092138215384832 no 364 0.125691883657534 713 6462575
SGTC_288 1315-0019 35.1 µM 1.14643679117121 0.0922445219220047 no 365 0.125807233496198 686 6811474
SGTC_373 0844-0104 25.9 µM 1.14278016896478 0.0929433860365239 no 366 0.126564937231793 714 5375804
SGTC_122 0236-0016 402.397 µM 1.14064305188343 0.093353646191765 no 367 0.127009246942278 737 6808838
SGTC_418 lividomycin a 100 µM 1.13996939231559 0.0934832448332364 no 368 0.127149526493131 724 72394 An antibiotic.
SGTC_2909 7941780 10.49 µM 1.13829428049166 0.093806078822863 no 369 0.127498810733773 690 1243215
SGTC_1188 1403-0014 4.57 µM 1.1367758639808 0.0940994243133582 no 370 0.127815997819759 734 9614867
SGTC_2314 7727897 200 µM 1.13376573198116 0.0946829566327735 no 371 0.128446414434428 639 900724
SGTC_1830 st055982 50.3 µM 1.13310716552088 0.0948109785618719 no 372 0.128584626307946 684 455313 An antimicrobial agent.
SGTC_2666 tannic acid 100 µM 1.13056161809028 0.0953070192944336 no 373 0.129119824967226 722 16134267 A thiamine antagonist.
SGTC_1449 4112-4002 201 µM 1.1303486706034 0.0953486019713512 no 374 0.129164666852664 646 2059539
SGTC_3090 9117696 49.47 µM 1.12844064709878 0.0957217816179097 no 375 0.12956693485211 665 7923821
SGTC_1317 1273-0028 910 nM 1.11804198160733 0.097774498388411 no 376 0.131774531867006 692 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_268 camptothecin 39.6153 µM 1.11626567541127 0.0981283478214172 no 377 0.13215421478479 785 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1281 0884-0031 11.8 µM 1.11435965450531 0.0985090795857402 no 378 0.13256246219413 723 1548255
SGTC_2605 digitonin 300 nM 1.11091819578302 0.0991992556657406 no 379 0.133301781276046 802 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_190 3970-0790 3.722 µM 1.10555683499833 0.100281498023709 no 380 0.134459190830741 669 2832352
SGTC_610 4215-0184 155 µM 1.10453870326368 0.100487987707899 no 381 0.13467976208349 739 5605015
SGTC_2551 apiole 73.87 µM 1.10449386557861 0.100497088470364 no 382 0.134689481565501 546 10659 A possible DNA adduct former.
SGTC_2748 diazoxide 86.69 µM 1.10416725085889 0.100563400024281 no 383 0.134760296486421 637 3019 A potassium channel activatior.
SGTC_3319 9138450 16.7555 µM 1.10347125958644 0.100704811401017 no 384 0.134911282939454 671 2029690
SGTC_1590 st077108 57.8 µM 1.09663902753609 0.102100688734442 no 385 0.136399609890081 702 5489485
SGTC_1401 3807-4679 7.6 µM 1.09615523105533 0.102200063126266 no 386 0.136505423850336 674 3291456
SGTC_2259 7964009 200 µM 1.09570266454283 0.102293086389476 no 387 0.136604458133076 659 313134
SGTC_1270 0831-1170 17.3 µM 1.08648856145352 0.104200417319238 no 388 0.13863144943646 783 6764716
SGTC_383 2324-0395 7.37 µM 1.08568753136626 0.104367441524309 no 389 0.138808629470623 716 3146421
SGTC_197 4544-0043 41.561 µM 1.08400553452914 0.104718788894767 no 390 0.139181172463294 734 896523
SGTC_2774 tamoxifen 10.92 µM 1.0837977399231 0.10476225387756 no 391 0.139227243763844 720 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1403 3909-7815 62.9 µM 1.08250877572111 0.105032162039219 no 392 0.13951325903912 673 6615483
SGTC_2519 cryptotanshinone 88.04 µM 1.08067363067872 0.105417307984804 no 393 0.139921158418469 713 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1646 st011709 75.6 µM 1.07914289171577 0.105739348162332 no 394 0.140262016578183 674 5757843
SGTC_2661 dactinomycin 12.96 µM 1.07404165425609 0.106817690718884 no 395 0.141402006392519 764 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1956 st077085 54 µM 1.0699419317416 0.107690058487135 no 396 0.142322723600421 761 24208685
SGTC_1146 3579-1023 7 µM 1.06978937700697 0.107722618918052 no 397 0.142357062494675 814 X1146
SGTC_2148 5546263 113.568 µM 1.06920369434722 0.10784768963516 no 398 0.142488947207803 729 792097
SGTC_927 2425-1185 123 µM 1.06840804766324 0.108017765021628 no 399 0.142668244216737 721 730375
SGTC_709 3807-1509 243 µM 1.06795020588172 0.108115719594625 no 400 0.14277148684309 735 1886677 YPL242C IQG1
SGTC_3238 9133470 49.47 µM 1.06564533846351 0.10860981391405 no 401 0.143291997930121 727 3534688
SGTC_166 k072-0058 166.424 µM 1.06476417629694 0.108799137109292 no 402 0.143491330087056 752 5846229
SGTC_2777 climbazole 1.536 µM 1.06411277105826 0.108939248065627 no 403 0.143638808051646 759 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_162 k030-0015 37.8 µM 1.05782665469513 0.110297999673323 no 404 0.145067239220821 783 1809920 YMR134W ERG29
SGTC_1682 st012968 530 nM 1.05743210460997 0.110383685696311 no 405 0.145157212938871 667 24207270
SGTC_2595 hexamethylquercetagetin 100 µM 1.05415175611689 0.111097940621608 no 406 0.145906721816146 696 386331
SGTC_1330 1469-0054 61.8 µM 1.05353461966069 0.11123268344954 no 407 0.14604801808683 788 7102664
SGTC_415 dibenzyl ketone 100 µM 1.04894376883505 0.112238702835803 no 408 0.147101999704357 771 7593
SGTC_965 1291-5240 308 µM 1.04572858378875 0.112947125729887 no 409 0.147843180932374 777 2834598
SGTC_2770 toltrazuril 17.5 µM 1.0453709875114 0.113026114059329 no 410 0.147925770132533 791 68591 Kills coccidiodes.
SGTC_2130 NSC 7 2.4545 µM 1.04395173565226 0.113339996899717 no 411 0.148253860127702 802 21448
SGTC_720 r052-1644 49.9 µM 1.04061359409302 0.114080712597445 no 412 0.149027459739143 677 1422863 YOR257W CDC31
SGTC_1264 0783-0040 158 µM 1.04001783089852 0.114213271062193 no 413 0.149165808305069 720 2855798
SGTC_89 0302-0250 142.109 µM 1.03975863980818 0.114270975811928 no 414 0.149226024617499 812 4203518 YLR208W SEC13
SGTC_576 1073-0113 22.7 µM 1.0397521424079 0.114272422620847 no 415 0.149227534328088 942 5439563
SGTC_468 gf-109203x 121 µM 1.03740429857673 0.11479608313836 no 416 0.149773737923784 630 2396 A protein kinase C inhibitor.
SGTC_1691 st019933 84.6 µM 1.03563637119027 0.115191524932345 no 417 0.150185908566733 764 6176082
SGTC_1941 st076221 61.8 µM 1.03552864247872 0.115215652455785 no 418 0.150211048612896 800 2828568
SGTC_1132 3456-3614 2.5 µM 1.03531341242344 0.115263867338645 no 419 0.15026128404495 867 3125502
SGTC_2815 7968870 71.43 µM 1.03527067322774 0.115273443290353 no 420 0.150271260851867 778 2977326 YHR190W ERG9
SGTC_35 0133-0054 64.071 µM 1.03395469856163 0.115568571467142 no 421 0.150578670933796 695 99677
SGTC_3334 9142812 21.919 µM 1.03077165619879 0.116284637649233 no 422 0.151323956433348 750 45283678
SGTC_420 mitomycin C 81.9 mM 1.0303257582688 0.11638519895075 no 423 0.151428555666213 767 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2457 5731572 11.68 µM 1.02909453947425 0.116663190358242 no 424 0.151717625940708 784 2865357
SGTC_2848 9016370 25.97 µM 1.0284364243308 0.116811976188543 no 425 0.151872291045554 831 7894410
SGTC_1784 st039334 36.3 µM 1.02830200979498 0.116842380989818 no 426 0.15190389298265 754 3496984
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.02784492159137 0.116945817107593 no 427 0.152011390775942 817 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2045 5106652 78.05 µM 1.02681451815008 0.117179228768013 no 428 0.15225390587866 789 673349
SGTC_363 0455-0021 3.06 µM 1.02402859404425 0.117811960777396 no 429 0.152910884653836 772 4597466
SGTC_1118 chelidonine 707.474 nM 1.02377500481755 0.117869675137382 no 430 0.15297077945801 841 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2231 micatex 6.853 µM 1.02139899064715 0.118411404027091 no 431 0.153532721680703 760 20737 An antifungal of unknown mechanism.
SGTC_556 4058-0063 51.5 µM 1.02093932433974 0.118516410342026 no 432 0.153641593263764 836 6615692
SGTC_2417 cerulenin 830 nM 1.02001232666707 0.118728374121318 no 433 0.153861307344486 767 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_3086 9117350 49.47 µM 1.01940571294963 0.118867225003813 no 434 0.154005197533665 737 2679265
SGTC_1672 st016598 6.51 µM 1.01822843645285 0.11913702496369 no 435 0.154284704257612 766 4665860 YNL267W PIK1
SGTC_491 tetrandrine 80.3 µM 1.0172760568872 0.119355600721484 no 436 0.154511061689982 751 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1397 3532-0190 20.1 µM 1.01622952511672 0.119596111023345 no 437 0.154760049826184 717 5322280
SGTC_2471 5466956 24.79 µM 1.01571457152291 0.119714581278798 no 438 0.154882663512745 769 724419
SGTC_61 0978-8327 98.565 µM 1.01514939119169 0.119844701935149 no 439 0.15501731034098 824 6150059 YHR072W ERG7
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.01417581789081 0.120069080083628 no 440 0.155249432663658 770 803109
SGTC_2497 7-hydroxyflavone 100 µM 1.0137177389954 0.120174755278962 no 441 0.15535872856139 725 5281894
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.01276175274687 0.120395504838127 no 442 0.155586986798075 838 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1239 0337-0584 35.4 µM 1.01217962215559 0.120530066130762 no 443 0.155726088846749 860 914301 YML130C ERO1
SGTC_2650 prasterone 100 µM 1.0112536363461 0.120744328774564 no 444 0.155947525178904 712 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_25 0118-0223 35.662 µM 1.01069947721427 0.120872683094101 no 445 0.156080143674873 789 5333628
SGTC_1715 st032160 10.2275 µM 1.0106195085728 0.120891213353272 no 446 0.156099287490844 762 5289825
SGTC_2575 plumbagin 510 nM 1.0084338512152 0.121398445996595 no 447 0.156623114410806 766 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1530 rhein 70.4 µM 1.00527112350608 0.122135076762493 no 448 0.157383157889309 840 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_384 k007-0144 5.16 µM 1.00463531954651 0.12228353991773 no 449 0.157536241807264 825 6824886
SGTC_2814 7977482 42.97 µM 1.00133626955643 0.123055917189313 no 450 0.158332131852108 860 6456762
SGTC_2552 juarezic acid 87.02 µM 1.00058221359413 0.123232936726475 no 451 0.158514416296989 955 1549512
SGTC_1260 0700-1617 7.75 µM 0.999401614938483 0.12351044820369 no 452 0.158800088918916 815 2853078
SGTC_1064 honokiol 6.76 µM 0.998784656078801 0.123655644539424 no 453 0.158949510283307 817 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2962 9082311 13.18 µM 0.998680193067919 0.123680240901025 no 454 0.15897481931421 737 16459453
SGTC_2361 9034121 116 µM 0.998584828970301 0.123702697866881 no 455 0.15899792618923 774 6496917
SGTC_2827 7993847 71.43 µM 0.997907228233503 0.123862345964725 no 456 0.159162173310487 722 2985692
SGTC_108 0509-0257 621.132 µM 0.996610570988426 0.124168250594159 no 457 0.159476786429981 828 536624
SGTC_515 4092-1064 102 µM 0.995930075774783 0.124329002883712 no 458 0.159642060475237 865 717353
SGTC_1043 0916-0009 19.3 µM 0.993522060505462 0.124899013025321 no 459 0.160227802602245 923 3101130
SGTC_2514 salinomycin 42.74 µM 0.992172899689975 0.125219174697688 no 460 0.160556594975211 890 23682228 A polyether potassium ionophore.
SGTC_547 1120-0019 610 nM 0.990832953463378 0.125537716457198 no 461 0.160883577654696 796 3676939
SGTC_2741 miltefosine 3.04 µM 0.990186153203862 0.125691680709018 no 462 0.161041569656109 718 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_3062 9077494 49.47 µM 0.989256378907186 0.125913234780028 no 463 0.161268860225151 783 16459633
SGTC_3251 9135047 49.47 µM 0.989127319384485 0.125944009629405 no 464 0.16130042636189 794 17682963
SGTC_2902 5787006 60.46 µM 0.987296453710649 0.126381153202603 no 465 0.161748664333028 780 591003
SGTC_2150 5556613 200 µM 0.985325616581571 0.126852897145981 no 466 0.162232076870261 850 743190
SGTC_911 3456-4043 236 µM 0.985261877171364 0.126868174389896 no 467 0.162247726740708 845 914281
SGTC_71 0417-1750 47.813 µM 0.984181506550445 0.127127315566411 no 468 0.162513138515966 859 6811472
SGTC_2669 eugenol 100 µM 0.982077872217851 0.127632956326497 no 469 0.163030742908764 767 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_11 0438-0307 1.3 µM 0.981908026346704 0.127673842299284 no 470 0.163072580605797 803 4011476
SGTC_1439 4092-1168 46 µM 0.979531059709875 0.128246990563184 no 471 0.163658824836209 834 2886240
SGTC_1493 4348-0038 111 µM 0.977200510326835 0.128810678745624 no 472 0.164234947708526 882 800424
SGTC_1521 st012942 49.4 µM 0.977115198860106 0.128831345522431 no 473 0.164256062031077 878 24207259
SGTC_1660 st012960 28.1 µM 0.976245137910709 0.129042249894761 no 474 0.164471499921316 796 24207266
SGTC_820 1582-0060 59.9 µM 0.975807809070679 0.129148349571231 no 475 0.164579857105855 830 3848840
SGTC_2234 tolnaftate 200 µM 0.975486659798403 0.129226301604363 no 476 0.164659457873872 802 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1942 st076330 65.2 µM 0.975103302177961 0.129319396062261 no 477 0.164754510396148 809 24208414
SGTC_712 r015-0009 80.6 µM 0.97410018276322 0.129563213200679 no 478 0.165003399398881 784 6813872 YLR060W FRS1
SGTC_1512 0259-0544 12.2 µM 0.970176234520284 0.130520022211497 no 479 0.165979327301988 867 18476
SGTC_295 k015-0027 31 µM 0.970039627419385 0.13055342004703 no 480 0.166013370004637 824 3887424
SGTC_2761 levamisole 97.89 µM 0.962818077640373 0.132327369509659 no 481 0.167819413503668 830 26879 An alkaline phosphatase inhibitor.
SGTC_800 3448-7362 155 µM 0.962608145129803 0.132379186041824 no 482 0.167872104221092 1034 15991913
SGTC_1402 3909-7673 35.9 µM 0.961656064847567 0.132614358492223 no 483 0.168111199404977 822 5328014
SGTC_761 k216-0224 480 µM 0.961406964311146 0.132675936052611 no 484 0.168173791977141 913 1340404
SGTC_884 0851-0618 334 µM 0.96115763435056 0.13273759004578 no 485 0.16823645721033 866 9642473
SGTC_2507 purpurin 79.67 µM 0.960990512143405 0.132778926855206 no 486 0.168278469202431 837 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2754 granisetron 64.02 µM 0.959043273547428 0.133261219659761 no 487 0.168768472823222 828 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2389 9091542 195.52 µM 0.957623482734519 0.13361363294869 no 488 0.169126326741278 856 3626624 YOL127W RPL25
SGTC_596 1155-0152 116 µM 0.957526231003369 0.133637795710526 no 489 0.169150856559477 878 280313
SGTC_349 k015-0014 24 µM 0.956406560429168 0.133916200844951 no 490 0.169433435772674 792 2196908
SGTC_2384 9036245 200 µM 0.954669986680763 0.134348786466934 no 491 0.16987230614964 874 6462766
SGTC_1884 5633444 25 µM 0.953894328454517 0.13454231488933 no 492 0.170068567313215 861 5724239
SGTC_3133 9127736 49.47 µM 0.953436602872309 0.134656608162295 no 493 0.170184451626576 845 27243420
SGTC_1250 0485-0349 40.2 µM 0.951645048154441 0.135104596928026 no 494 0.170638513521687 809 6842794 YDL195W SEC31
SGTC_818 4072-2707 53.5 µM 0.948361287460329 0.135928371483324 no 495 0.171472780118096 839 882871
SGTC_1404 3909-7820 48.3 µM 0.94780144817281 0.136069156941523 no 496 0.171615271579998 864 23741373
SGTC_1741 st038134 10.228 µM 0.947387075458185 0.13617342548384 no 497 0.171720787291841 909 1272587
SGTC_1924 st058459 75.1 µM 0.947111586556562 0.136242776967865 no 498 0.171790960610466 843 688683
SGTC_890 0929-0006 47.2 µM 0.946694188381946 0.136347898688158 no 499 0.171897316354229 840 1378169
SGTC_2670 beta-carotene 100 µM 0.946610422293443 0.136369001859383 no 500 0.171918665557617 813 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_973 1325-0077 65.9 µM 0.944977323651875 0.136780874490419 no 501 0.172335226564616 924 2835149
SGTC_2468 5987765 72.9 µM 0.939542940893783 0.138157561873807 no 502 0.173726028060235 917 26772094
SGTC_2421 5690543 90.72 µM 0.937599754869958 0.138652112809929 no 503 0.174225068705484 857 3397993
SGTC_32 0928-0142 34.1 µM 0.936973363341492 0.138811789426424 no 504 0.174386129844492 861 2244242
SGTC_446 go6976 132 µM 0.936625138510978 0.13890061131102 no 505 0.17447570816963 836 3501 A protein kinase C inhibitor.
SGTC_1156 4092-0367 4.88 µM 0.93536757579619 0.139221700660625 no 506 0.174799450408995 874 1357585
SGTC_1696 st025591 34.7925 µM 0.933969277960448 0.139579316068337 no 507 0.175159870354418 878 2787147
SGTC_1358 1509-0022 2.48 µM 0.933644071472149 0.139662577258068 no 508 0.175243761858218 897 3258434
SGTC_1342 1486-1464 234 µM 0.933354542959129 0.13973673238333 no 509 0.175318471172294 875 3253938
SGTC_1954 st077032 68.9 µM 0.933153146034359 0.139788330699933 no 510 0.175370451108833 766 698907
SGTC_2976 9009005 19.48 µM 0.932119988389083 0.140053231497384 no 511 0.175637259574629 891 2993148
SGTC_758 0868-0029 16 µM 0.927613833663654 0.141212592334792 no 512 0.176803959626418 906 762687
SGTC_2280 7785178 200 µM 0.926532250693942 0.141491831715617 no 513 0.177084722432635 861 2954328
SGTC_1467 k284-1082 293 µM 0.923674575393935 0.142231415846254 no 514 0.177827886617905 905 3334705
SGTC_328 k915-0120 63.5 µM 0.922809383151035 0.142455847949161 no 515 0.178053275058068 880 6624543
SGTC_1066 ketoconazole 628 nM 0.920591777918648 0.143032191257456 no 516 0.178631798243496 943 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_698 k064-0052 127 µM 0.920260080804181 0.143118532758064 no 517 0.178718432193149 900 5088751
SGTC_766 1391-0721 126 µM 0.916441049850587 0.144115171450688 no 518 0.179717806593475 912 1020919 YIL115C NUP159
SGTC_413 propylparaben 100 µM 0.916015192895146 0.144226595110555 no 519 0.17982946318176 875 7175 A pharmaceutical preservative.
SGTC_309 k408-0051 1.48 µM 0.911783411621033 0.145336978348887 no 520 0.180941372212853 936 3640463
SGTC_479 n-linoleoylglycine 10 µM 0.906670140125305 0.146686310719372 no 521 0.182290629153804 852 6433346 An anti-infammatory.
SGTC_701 4424-0219 185 µM 0.904838192878603 0.147171778950922 no 522 0.182775557376704 963 2911779
SGTC_1808 st050063 61.5 µM 0.901116653745805 0.148161304507151 no 523 0.183763149571085 897 4011993
SGTC_1339 1486-1321 22.7 µM 0.900926286505902 0.148212040941038 no 524 0.183813756913356 905 3469382
SGTC_2662 daunorubicin 22.37 µM 0.900623842156719 0.148292671925141 no 525 0.183894176752295 874 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1128 3448-9350 235 µM 0.899352641061151 0.148631892096995 no 526 0.184232428188674 806 619386
SGTC_1032 k061-1018 98.7 µM 0.894396481861509 0.149959394565481 no 527 0.185554897081453 984 4005393
SGTC_378 3970-0959 8.33 µM 0.893262157110184 0.150264330785446 no 528 0.185858399278634 908 6615653
SGTC_3328 9140624 29.0385 µM 0.892964558564902 0.150344401456255 no 529 0.185938076293286 943 4904392
SGTC_244 nsc-207895 1.295 µM 0.8929429967907 0.150350203885078 no 530 0.185943849919114 812 42640
SGTC_3205 9113483 49.47 µM 0.889850831442085 0.151183873099477 no 531 0.186772994082413 916 17018033
SGTC_1693 xanthone 101.9 µM 0.887002852689326 0.151954423405986 no 532 0.187538682315772 950 7020 An insecticide.
SGTC_2181 6316240 54.2555 µM 0.886839074379782 0.151998814519712 no 533 0.187582773542007 873 12779990
SGTC_2085 5307070 144.047 µM 0.885542674194941 0.152350499818826 no 534 0.187932007104816 873 2840351
SGTC_2906 7926292 26.41 µM 0.885362009654163 0.152399553042123 no 535 0.18798070766279 935 2966319
SGTC_3339 9145883 14.936 µM 0.885207718528501 0.152441453772405 no 536 0.188022305079435 879 2030670
SGTC_3244 9134489 49.47 µM 0.884646719597528 0.152593868280879 no 537 0.188173600200329 917 16584271
SGTC_1301 naphtanilide LB 4.81 µM 0.883150984512859 0.153000729745498 no 538 0.188577350217266 996 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_472 calcifediol 10 µM 0.882320172210314 0.153227033037308 no 539 0.188801845413595 856 5283731 A vitamin D metabolite.
SGTC_1412 3909-8563 178 µM 0.882308761198595 0.153230142803185 no 540 0.188804929948504 1027 23767530
SGTC_1104 tacrolimus 29.8 µM 0.882267151842084 0.153241482674091 no 541 0.188816177725466 946 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2944 9067346 25.62 µM 0.881691440883674 0.153398439265409 no 542 0.188971845401098 864 6473075
SGTC_1882 5615643 20 µM 0.881609709101932 0.153420730503209 no 543 0.18899395143349 891 2253075
SGTC_714 4296-0578 26.1 µM 0.881099700083325 0.153559877030731 no 544 0.18913192978722 946 1589775
SGTC_1980 st071811 45.7 µM 0.880640554106702 0.153685217982339 no 545 0.189256200650647 930 4974850
SGTC_1523 st012844 44.7 µM 0.878803818026305 0.154187300598527 no 546 0.189753827888695 918 4274103
SGTC_597 k018-0003 82.8 µM 0.877229596623552 0.154618485727503 no 547 0.190180971744589 1027 6786234
SGTC_2739 tacrine 100.86 µM 0.873550718277654 0.155629248541293 no 548 0.191181487156909 914 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_280 3448-3607 3.04 µM 0.873227458165218 0.15571827129213 no 549 0.191269555621337 964 626179
SGTC_226 1,3-diallylurea 8.28947 mM 0.871713898221046 0.156135537889797 no 550 0.191682238164121 911 74537 YKL182W FAS1
SGTC_1465 k213-0056 144 µM 0.87170125682103 0.156139026040571 no 551 0.191685687223534 892 24048857 YMR208W ERG12
SGTC_917 harmaline 728.087 nM 0.8711176879354 0.156300106527863 no 552 0.191844948600017 936 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1753 st043925 64 µM 0.869916560951445 0.156631993819717 no 553 0.192173002186546 979 670181
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.869832068972543 0.15665535752398 no 554 0.192196091673655 978 6708739 YPR165W RHO1
SGTC_1845 st056753 3.01 µM 0.869431846935785 0.156766058004798 no 555 0.192305485130531 958 5375839
SGTC_1392 3455-1037 33.9 µM 0.867275452654473 0.157363397380017 no 556 0.192895551593819 923 981132
SGTC_1937 st074714 47.2 µM 0.866036628721495 0.157707237819508 no 557 0.193235037649091 976 17250970
SGTC_677 0929-0063 136 µM 0.865411133650465 0.157881033789047 no 558 0.193406586143576 902 1539583
SGTC_1279 0874-0590 65.2 µM 0.86500884834898 0.157992876582865 no 559 0.193516966130872 945 3523074
SGTC_2886 9058944 51.95 µM 0.864998703216518 0.157995697790599 no 560 0.193519750272827 820 4949929
SGTC_466 geldanamycin 89.2 µM 0.864664503688506 0.158088652109362 no 561 0.193611478744509 866 5288382 HSP90 inhibitor.
SGTC_2133 5320837 200 µM 0.863603833945518 0.158383904701505 no 562 0.193902778651494 895 2841355
SGTC_3254 9136651 49.47 µM 0.863149035836307 0.158510614999761 no 563 0.194027765139424 995 16454030
SGTC_1734 st037168 69.4 µM 0.862917519687232 0.158575142733164 no 564 0.194091408682553 915 708907
SGTC_2693 st077581 40.7 µM 0.86288713808242 0.158583611913759 no 565 0.194099761497259 1011 25238761
SGTC_1656 st012921 11 µM 0.860143283886429 0.159349712162227 no 566 0.194855032031383 894 6732821
SGTC_1751 st044839 27.194 µM 0.859374153490586 0.159564892022871 no 567 0.195067062387528 969 5291326
SGTC_682 0kpi-0099 17 µM 0.858883145402639 0.15970236092786 no 568 0.195202494573982 958 1714895 YML126C ERG13
SGTC_1396 3511-0007 98.6 µM 0.858664247522908 0.159763671345817 no 569 0.195262890439679 870 X1396
SGTC_2898 9056270 58.44 µM 0.857010296732176 0.160227418900741 no 570 0.195719597037782 922 19154699
SGTC_1634 st006576 41 µM 0.856942399940454 0.160246475113196 no 571 0.195738359271776 960 3915356
SGTC_3034 9090421 49.47 µM 0.856613506184644 0.160338804849649 no 572 0.195829259453752 921 17173761
SGTC_82 0054-0107 293.755 µM 0.855610427934008 0.160620611812438 no 573 0.196106649994338 979 3104697
SGTC_1799 st045822 46.1415 µM 0.853901468699632 0.161101475123423 no 574 0.196579792866293 952 3674992
SGTC_1534 6-azauridine 81.6 µM 0.85279279010445 0.161413934614203 no 575 0.196887111443899 1051 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_3089 9117425 49.47 µM 0.851204731670858 0.161862185984628 no 576 0.197327817419819 901 9401657
SGTC_470 aa-861 153 µM 0.849426604440286 0.162365048426577 no 577 0.197821977263178 964 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2608 thymoquinone 42.66 µM 0.849217203623265 0.162424334782785 no 578 0.197880221073026 925 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2709 st078560 56 µM 0.842816542292516 0.164243310027452 no 579 0.199665527422493 992 17250903
SGTC_846 0335-0850 148 µM 0.842135717450741 0.164437564893395 no 580 0.199855995291208 978 6819598
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.840374983364577 0.164940632831321 no 581 0.200349085552085 1035 688788
SGTC_2019 4016004 108 µM 0.839867443126993 0.165085829486504 no 582 0.200491356828274 947 45595336
SGTC_2938 9059746 27.26 µM 0.839638591236236 0.165151326288424 no 583 0.200555527349242 927 6471769
SGTC_223 busulfan 5 mM 0.838922032094416 0.165356512375428 no 584 0.20075653169454 913 2478 A DNA alkylator.
SGTC_410 α-linolenic acid 100 µM 0.838768575051531 0.165400476101658 no 585 0.200799594146009 1001 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3050 9093513 49.47 µM 0.838713277316058 0.165416320137652 no 586 0.20081511291593 1023 25236664
SGTC_889 0919-1524 82.7 µM 0.836719881040033 0.165988128314841 no 587 0.201375020654881 942 3905452
SGTC_3278 9139605 49.47 µM 0.833464419104857 0.166924704504804 no 588 0.202291428346413 958 7958859
SGTC_1606 st000094 49.2 µM 0.832802423812561 0.167115572670233 no 589 0.202478083768945 1052 1242210
SGTC_2641 levomentholum 100 µM 0.832205548820742 0.167287785768327 no 590 0.202646466191318 964 16666
SGTC_3068 9116768 49.47 µM 0.831163413997367 0.167588741360966 no 591 0.202940659927675 966 41904888
SGTC_2029 5175081 200 µM 0.83081084637721 0.167690637413738 no 592 0.203040247172662 1055 1380876
SGTC_1280 0880-0253 10.1 µM 0.829164177921546 0.168167071535027 no 593 0.203505756067388 980 6836607
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.826326729771549 0.168990077653851 no 594 0.20430938728669 994 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2847 9005661 71.43 µM 0.826323487339747 0.16899101960351 no 595 0.204310306698159 914 2991449
SGTC_1735 st034310 56.75 µM 0.826064873455327 0.169066159650312 no 596 0.204383646188229 969 871153
SGTC_3314 9135860 59.4275 µM 0.825597477204087 0.169202015661489 no 597 0.204516233356179 1033 25252478
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.825536389240497 0.169219777008638 no 598 0.204533566074324 861 6708630 An antioxidant.
SGTC_220 paclitaxel 373.376 µM 0.825187178711386 0.169321333072573 no 599 0.204632665674181 927 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1744 st037937 38.9 µM 0.824506625203359 0.169519361415008 no 600 0.204825876451655 1004 1016152
SGTC_953 1188-0045 9.7 µM 0.82424986770847 0.169594111636409 no 601 0.204898798698301 1018 6144426
SGTC_874 0599-0792 117 µM 0.824040973420171 0.16965494296362 no 602 0.204958138599834 1070 765305
SGTC_1603 st002045 67.8 µM 0.823152186881265 0.169913919613733 no 603 0.205210727403799 1024 5887985
SGTC_2174 5790901 200 µM 0.822736779120489 0.170035048941596 no 604 0.205328847662538 971 786020
SGTC_1123 mangostin 811.285 nM 0.821384653409583 0.170429700320355 no 605 0.205713601122412 944 5281650 An antioxidant.
SGTC_2299 7976368 114.88 µM 0.82108039612001 0.170518586137173 no 606 0.205800237840873 992 2979718
SGTC_1875 nocodazole 6 µM 0.82055564033519 0.170671958185116 no 607 0.205949711971134 1024 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1548 st061468 90.8 µM 0.820366489011652 0.170727263691202 no 608 0.206003606589887 1033 390799
SGTC_57 miconazole 162.5 nM 0.819723790868971 0.170915266365634 no 609 0.206186792146172 972 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2267 7931562 200 µM 0.816610911203565 0.171827722414392 no 610 0.207075408807444 906 934880
SGTC_950 1165-0508 94.1 µM 0.815143129944122 0.172259039836369 no 611 0.207495193092646 960 6148369
SGTC_1600 coumarin 106 71.1 µM 0.815135110229735 0.172261398379489 no 612 0.207497488105359 1035 100336 A hepatotoxic, DNA x-linker.
SGTC_351 caspofungin 25 nM 0.815056225712814 0.1722845988742 no 613 0.207520063395795 1118 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_3292 9120825 59.784 µM 0.814524956145282 0.172440900936563 no 614 0.207672140728896 1047 24824900
SGTC_475 α-linolenic acid 10 µM 0.814038877010178 0.172583986962352 no 615 0.207811339843006 1116 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_522 1273-0010 11.6 µM 0.810792529979983 0.173541547234328 no 616 0.208742412515092 1020 5705015
SGTC_1086 cerivastatin 2.18 µM 0.809871539434546 0.173813822138726 no 617 0.209007005363157 1014 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_117 lucigenin 22.078 µM 0.809869753065573 0.173814350511645 no 618 0.209007518763824 1068 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_3306 9127676 59.7925 µM 0.808993934930304 0.174073523370326 no 619 0.209259317464632 1007 41905287
SGTC_3287 9117173 37.0625 µM 0.808831753929541 0.17412154305583 no 620 0.209305964271286 1014 2789709
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.802807271719122 0.175911277150111 no 621 0.211043069260706 928 88881 An O-methylated flavonoid and antioxidant.
SGTC_539 4859-0462 2.54 µM 0.802300282674201 0.176062421470166 no 622 0.211189639472647 1070 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1177 0983-0204 23.6 µM 0.801194201551189 0.176392453245819 no 623 0.211509613764937 1072 766818
SGTC_2991 9074669 71.4286 µM 0.797327529273976 0.177549261527896 no 624 0.212630418047194 1053 17333109
SGTC_1366 1683-0113 21.9 µM 0.794640762592482 0.178355885428872 no 625 0.2134112498371 1072 708623
SGTC_1331 1472-0049 76.2 µM 0.791649237486123 0.179256716300336 no 626 0.214282614393293 1035 24051409
SGTC_641 4092-0595 30 µM 0.790665887774885 0.179553453860728 no 627 0.214569493565196 1050 786260
SGTC_2534 helenine 20.12 µM 0.789450529239384 0.179920629179912 no 628 0.214924366523127 1035 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2328 6201408 200 µM 0.788915575445264 0.180082394898188 no 629 0.215080675847771 984 2890418
SGTC_2900 5328528 85.29 µM 0.787435782570691 0.180530347794252 no 630 0.215513403429756 1137 795359
SGTC_2458 5808907 16.39 µM 0.786925876878224 0.180684864764016 no 631 0.215662629204409 1129 2731747
SGTC_2145 5634607 200 µM 0.786500915098003 0.180813704472515 no 632 0.215787041587292 1017 308662
SGTC_1049 3226-0134 66 µM 0.786122058287353 0.180928614641651 no 633 0.215897991283673 1097 5702385
SGTC_3349 9149703 23.001 µM 0.78532491142378 0.181170544798492 no 634 0.216131546773257 1081 4910494
SGTC_614 0462-0418 107 µM 0.782685885558968 0.181972921107863 no 635 0.216905796340557 972 5188303
SGTC_1036 k216-0215 33.5 µM 0.781279971903513 0.182401284586545 no 636 0.217318923502355 1036 622330
SGTC_3180 9109287 49.47 µM 0.780908193192786 0.182514665928367 no 637 0.217428246446845 1022 18891271
SGTC_2775 cyproheptadine 69.59 µM 0.78012208995848 0.182754548714142 no 638 0.217659507607791 1114 2913 A selective serotonin reuptake inhibitor.
SGTC_795 0685-0265 78 µM 0.779630942011647 0.182904524481423 no 639 0.217804068840354 1141 302754
SGTC_2074 5212007 75.395 µM 0.775848031900101 0.184062237583321 no 640 0.21891935995547 1014 758611
SGTC_3168 9103419 49.47 µM 0.773539584342755 0.184770945836796 no 641 0.219601555715165 1029 16649256
SGTC_1326 1431-2094 10.8 µM 0.773155547026072 0.184889012121464 no 642 0.219715165309782 1074 616278
SGTC_2337 9009472 200 µM 0.770295512277575 0.185769759292982 no 643 0.220562308923443 1083 5742383
SGTC_2646 retinol 96.75 µM 0.767072292275601 0.186765462771419 no 644 0.221519267358882 1097 445354 A vitamin A analog and teratogen.
SGTC_1372 2752-0194 270 µM 0.765248443000723 0.187330339216777 no 645 0.222061809134348 1032 823334
SGTC_1228 0124-0032 52.5 µM 0.764258900954116 0.187637258356465 no 646 0.222356486068384 1115 X1228
SGTC_2046 4110841 106 µM 0.763783896970431 0.187784697219332 no 647 0.222498017284954 1104 44119630 YMR134W ERG29
SGTC_3056 9094900 49.47 µM 0.763664095708346 0.187821894228353 no 648 0.222533721134586 1057 25236784
SGTC_1719 st032227 49.2 µM 0.763474573214327 0.18788074822571 no 649 0.222590210371411 1131 3125804
SGTC_733 4069-0007 56.1 µM 0.762867358249696 0.188069388420891 no 650 0.222771252429607 1114 5717425 YNL287W SEC21
SGTC_2852 9023854 51.95 µM 0.762815726129737 0.188085434084097 no 651 0.222786650494052 1112 19798528
SGTC_2414 st077232 92.9 µM 0.761709771325928 0.188429333434509 no 652 0.223116621078712 1018 729801
SGTC_2980 9014342 25.29 µM 0.758849584738685 0.189320512275124 no 653 0.223971270089134 1051 2996599
SGTC_764 1951-2361 146 µM 0.757941713983877 0.189603928852011 no 654 0.22424293829754 1080 5438930
SGTC_721 1187-1332 279 µM 0.757248565526359 0.189820489636339 no 655 0.224450479619338 1004 25730
SGTC_654 1124-0271 80.9 µM 0.757081532633781 0.189872698555635 no 656 0.224500508615725 1090 5403748
SGTC_2020 4017018 200 µM 0.756357492667065 0.190099111401358 no 657 0.22471744319727 1119 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1889 st059080 5.18 µM 0.755311280042639 0.190426563043525 no 658 0.225031116038314 1133 176925 Isolated from Daphnopsis sellowiana.
SGTC_2880 9042983 58.44 µM 0.754867808707346 0.190565468567262 no 659 0.225164151340103 1125 6464714
SGTC_1353 1498-1206 8.11 µM 0.753709326208333 0.190928625586454 no 660 0.225511890291411 1141 6756808
SGTC_2598 perillyl alcohol 100 µM 0.752050157200525 0.191449474869362 no 661 0.226010448137355 1102 10819 An apoptosis inducer.
SGTC_3139 9095020 49.47 µM 0.751444121666103 0.19163993949653 no 662 0.226192708859518 941 25236292
SGTC_316 k060-0003 58.6 µM 0.748621566319462 0.19252853918503 no 663 0.227042664867616 1143 6152314
SGTC_1283 0922-0125 16.4 µM 0.747680974429681 0.192825215886591 no 664 0.227326304813024 1129 3360884
SGTC_2269 7935389 174.42 µM 0.747099886087969 0.193008639296106 no 665 0.227501634482863 1056 97605
SGTC_573 3702-0553 84.7 µM 0.746077722658247 0.193331548681507 no 666 0.227810232864518 1095 1222756
SGTC_2220 6782180 200 µM 0.74475954093872 0.193748458907671 no 667 0.228208548819497 1060 833803
SGTC_2565 isoliquiritigenin 100 µM 0.743505108570278 0.194145715263669 no 668 0.228587964896855 1053 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_458 nppb 133 µM 0.743135567674199 0.194262836815742 no 669 0.228699803894438 1116 4549 A chloride channel blocker.
SGTC_2571 chrysanthemic acid 100 µM 0.74260307594703 0.194431679328412 no 670 0.228861012853928 1074 2743 An insecticide.
SGTC_1970 st070122 35.8 µM 0.742523288584527 0.194456986003937 no 671 0.228885173534792 1146 102928
SGTC_172 1112-0046 2.638 µM 0.74184475981049 0.194672280396224 no 672 0.229090698966587 1025 2802135 YIL048W NEO1
SGTC_1552 6-methylflavone 10.6 µM 0.741843970087386 0.194672531056585 no 673 0.229090938232926 1110 689013
SGTC_290 2043-6722 48.1 µM 0.740523825699748 0.195091823131869 no 674 0.22949110486598 1130 773758 YLR208W SEC13
SGTC_2184 6075246 200 µM 0.739884929644393 0.195294940369059 no 675 0.229684909763902 1110 2267320
SGTC_2201 6605497 169.863 µM 0.739522856993981 0.195410107187339 no 676 0.229794782793515 1129 670741
SGTC_731 3966-0296 387 µM 0.737630171965603 0.196012797081128 no 677 0.230369607717786 1173 660956
SGTC_192 3455-0609 60.9 µM 0.73688049932853 0.196251827644488 no 678 0.230597511918529 1174 3769639
SGTC_2359 9039622 200 µM 0.736783376991428 0.196282807696214 no 679 0.230627046806426 1127 6463596
SGTC_3313 9133968 57.047 µM 0.734975751389508 0.196859944488781 no 680 0.231177131073198 1133 1494643
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.734428580124916 0.197034847132044 no 681 0.23134378671798 1131 6708514
SGTC_2844 9010103 25.97 µM 0.733690095167652 0.1972710520401 no 682 0.231568818272161 1118 2480525
SGTC_2482 5981709 142.65 µM 0.733086176289165 0.197464343156036 no 683 0.231752935426385 1098 877755
SGTC_265 mycophenolic acid 32.932 µM 0.730754919958896 0.198211561914848 no 684 0.232464431654399 1219 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2740 felodipine 17.08 µM 0.729054070550382 0.198757796832155 no 685 0.232984294065073 1092 3333 L-type calcium channel blocker
SGTC_1880 MG-132 525 µM 0.728572408049742 0.198912649511282 no 686 0.23313163081107 1094 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2825 7998094 58.44 µM 0.728415942645835 0.198962968191948 no 687 0.233179503468188 1101 2987815
SGTC_2659 sanguinarine 24.21 µM 0.727859713106476 0.199141911601258 no 688 0.233349733416838 1115 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_259 usnic acid 108.925 µM 0.727307591531148 0.199319629289885 no 689 0.233518774324439 1205 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_991 3996-0057 64.7 µM 0.726488298384123 0.199583520483169 no 690 0.233769739226041 1103 715343
SGTC_1300 1094-0077 113 µM 0.725816480691347 0.19980006721052 no 691 0.233975641122525 1102 5532636
SGTC_1773 st048542 73.5835 µM 0.723628088671835 0.200506430078661 no 692 0.234647046096284 1117 3237138
SGTC_851 0394-0702 453 µM 0.723503229810018 0.200546776835546 no 693 0.234685385256308 1175 762646
SGTC_1054 3429-0080 167 µM 0.723242067225256 0.200631184391344 no 694 0.234765589033798 1169 1162877
SGTC_1451 4152-0210 104 µM 0.722851592840522 0.200757425204014 no 695 0.23488553309478 1153 659563
SGTC_59 0330-0160 1.33 µM 0.722072919362484 0.20100931351858 no 696 0.235124823381019 1174 4293482
SGTC_2617 dihydrotanshinone i 20.83 µM 0.721677606113266 0.201137263502994 no 697 0.235246356644985 1193 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_175 3793-3120 23.7 µM 0.721246793205563 0.201276759171357 no 698 0.235378843246189 1162 5322297
SGTC_3337 9144342 33.5465 µM 0.720829330638778 0.201411987363695 no 699 0.235507263536091 1163 17682949
SGTC_1629 st005085 44.9 µM 0.72015560694496 0.201630340754719 no 700 0.235714596668699 1161 24207091
SGTC_2008 4012253 172 µM 0.719975737759479 0.201688660209335 no 701 0.235769967005816 1181 603940
SGTC_663 1486-0733 13.9 µM 0.719898031761225 0.201713858152479 no 702 0.23579388998238 1144 722445 YPR165W RHO1
SGTC_2643 anethole 100 µM 0.719643174716334 0.201796514596672 no 703 0.235872361002371 1158 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1617 st002906 78 µM 0.719564120776404 0.20182215786572 no 704 0.235896704801596 1155 5150859
SGTC_2531 methyl deoxycholate 70.07 µM 0.719500470580495 0.201842805934457 no 705 0.235916306192091 1141 16667744 Haematoxylin.
SGTC_1822 st052468 42 µM 0.718690206188146 0.202105765523721 no 706 0.236165909529006 1153 2873678
SGTC_1653 st012112 65 µM 0.717387595598638 0.202528938381876 no 707 0.236567485677954 1137 720429
SGTC_1475 4092-1048 11.7 µM 0.717042719050807 0.202641065394731 no 708 0.236673869040121 1179 2881759
SGTC_1197 1601-0112 267 µM 0.716889997039938 0.202690730557062 no 709 0.236720987291721 1173 7350313
SGTC_1945 st075991 56.6 µM 0.71678861302113 0.202723704633257 no 710 0.236752269441656 1099 1084980
SGTC_1761 st044296 37 µM 0.716579374782454 0.202791767283226 no 711 0.236816837316463 1188 1826700
SGTC_1338 1486-1223 76 µM 0.716145117929156 0.202933069310969 no 712 0.236950873557098 1167 3444526
SGTC_3242 9133940 49.47 µM 0.715979815129047 0.202986872329699 no 713 0.237001906312151 1211 17248444
SGTC_1667 st014849 34.6 µM 0.715498285278563 0.203143649976103 no 714 0.237150600013161 1202 5348460
SGTC_497 capsazepine 133 µM 0.714912720557485 0.203334396914009 no 715 0.237331488133574 1149 2733484 A calcium channel blocker.
SGTC_3326 9140064 16.379 µM 0.71398579753935 0.203636559267102 no 716 0.237617980844898 1172 1868434
SGTC_3261 9137475 49.47 µM 0.712129414240842 0.204242515590392 no 717 0.238192320659224 1034 17027690
SGTC_2480 5767542 37.17 µM 0.70955662060272 0.205084093833078 no 718 0.23898956406838 1178 2867358
SGTC_3289 9119912 71.43 µM 0.708836844692197 0.205319905849418 no 719 0.239212865234591 1192 17014829
SGTC_1333 1482-0047 286 µM 0.706385219207517 0.206124311797502 no 720 0.239974305101182 1175 3811116
SGTC_3226 9131256 49.47 µM 0.705929304401069 0.206274108373068 no 721 0.240116051337024 1099 17178073
SGTC_1252 0493-0875 34.8 µM 0.705881302559025 0.206289883738833 no 722 0.240130978009386 1192 3960963
SGTC_1105 epirubicin 18.1 µM 0.705801926910649 0.206315971387483 no 723 0.240155661803013 1148 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.705757343181875 0.206330625160253 no 724 0.240169526807281 1192 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_3082 9117008 49.47 µM 0.705625618177726 0.206373924116568 no 725 0.240210494250403 1192 41448529
SGTC_3081 9117243 49.47 µM 0.705154641222092 0.206528781665628 no 726 0.240357002686483 1182 45595589
SGTC_2779 methotrexate 400 µM 0.70277868816999 0.207311045542684 no 727 0.241096840311683 1249 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1722 st034304 3.6505 µM 0.702070765380367 0.207544461895625 no 728 0.241317516461504 1209 4036148 YLR033W RSC58
SGTC_3284 9108171 64.8615 µM 0.701159248554433 0.207845235912596 no 729 0.241601819212153 1134 8687505
SGTC_424 splitomicin 100 mM 0.698147165125155 0.208840964797439 no 730 0.242542582219922 1168 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2027 5150920 200 µM 0.697824515235088 0.208947792197699 no 731 0.242643472859291 1187 786715
SGTC_1995 st072814 61.1 µM 0.696687134432448 0.209324628649322 no 732 0.242999306013454 1158 5769371
SGTC_2838 9002687 71.43 µM 0.696209634873472 0.209482952703633 no 733 0.243148777331512 1187 6457060
SGTC_2933 9026794 32.47 µM 0.695919282028858 0.209579259141985 no 734 0.243239690557297 1184 17586027
SGTC_589 1227-0070 34.1 µM 0.695336364085789 0.209772684399977 no 735 0.243422265156521 1192 2841384
SGTC_2873 9040596 71.43 µM 0.693233414528956 0.210471362008623 no 736 0.244081540855565 1199 6463863
SGTC_1809 st050081 57.6 µM 0.69288011199677 0.210588876041821 no 737 0.24419239577864 1259 5036894
SGTC_1620 st003704 16.5 µM 0.691966545726942 0.210892921126948 no 738 0.244479169171989 1185 2834414
SGTC_1096 rimcazole 32.2 µM 0.691818874947537 0.210942091771256 no 739 0.244525540857064 1144 18528119 A dopamine reuptake inhibitor.
SGTC_1017 4239-0030 168 µM 0.691312619790195 0.211110712981261 no 740 0.244684551426661 1186 1149593
SGTC_985 1493-0307 8.71 µM 0.689219787678097 0.211808621968148 no 741 0.245342483148982 1188 3278274
SGTC_775 4577-0580 57.3 µM 0.68918578874027 0.211819970925528 no 742 0.245353179370061 1263 2006902
SGTC_2124 5246320 200 µM 0.689087667498698 0.211852726114062 no 743 0.245384050166084 1190 579342
SGTC_2808 7946468 45.46 µM 0.6883374415441 0.212103267193187 no 744 0.245620154404814 1197 2970879
SGTC_2153 5569715 200 µM 0.687489007597758 0.212386813882423 no 745 0.245887312709141 1206 2054701
SGTC_719 2810-4230 27.3 µM 0.685008631315058 0.213217025012799 no 746 0.246669237190411 1190 721079
SGTC_1746 st038117 42 µM 0.684646008475346 0.213338557513218 no 747 0.246783663441469 1212 2898218
SGTC_1739 st037196 92.5 µM 0.684492912972455 0.213389879363427 no 748 0.246831981516821 1224 612214
SGTC_1219 1469-0211 33.1 µM 0.684326602098021 0.213445639526874 no 749 0.246884476199523 1183 6822282
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.684201355077016 0.21348763754196 no 750 0.246924013353054 1238 1273210
SGTC_1198 1612-1005 86.7 µM 0.683143361687399 0.21384259755909 no 751 0.247258128892468 1268 6998509
SGTC_130 0136-0219 337.655 µM 0.681102131833693 0.214528406722027 no 752 0.247903434121257 1179 234244
SGTC_716 1683-5115 658 µM 0.679766221028799 0.214977935331809 no 753 0.248326249100356 1252 723597
SGTC_1820 st053765 18.6 µM 0.679512412502164 0.215063402674825 no 754 0.248406622784864 1199 3690829
SGTC_1920 st075728 45.7 µM 0.679114258834169 0.215197516462357 no 755 0.248532734253868 1232 3400306
SGTC_747 3448-8087 38.7 µM 0.677791449516225 0.215643438978076 no 756 0.248951966609794 1234 5168703
SGTC_2585 alliin 100 µM 0.676463785509236 0.216091536264731 no 757 0.249373115661493 1302 87310 A garlic compound which reacts with lipids.
SGTC_2737 bleomycin 30.5 nM 0.675965957079659 0.216259696288038 no 758 0.249531129668944 1247 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_291 SEC14.278 35.5 µM 0.674895478458487 0.216621546659385 no 759 0.249871086706851 1226 1068044
SGTC_34 0469-0683 81.75 µM 0.673955527581677 0.21693956374477 no 760 0.250169794012284 1223 3690923
SGTC_1952 st077036 64.1 µM 0.673947791383457 0.216942182280735 no 761 0.250172253286883 1238 2937007
SGTC_2215 7188065 200 µM 0.673861764152899 0.216971301870836 no 762 0.250199601509014 1240 940217
SGTC_567 1080-0542 68.4 µM 0.673351475590321 0.217144077264125 no 763 0.250361855815317 1177 5950415
SGTC_232 clozapine 119 µM 0.667457972707478 0.219145273566503 no 764 0.252239823100822 1205 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_488 nitrendipine 139 µM 0.667213036116037 0.219228673035598 no 765 0.252318032708026 1273 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_865 0488-0499 301 µM 0.664292791704957 0.220224403540816 no 766 0.253251466832296 1262 9634651
SGTC_2545 solidagenone 89.61 µM 0.661508425957565 0.221176213404494 no 767 0.254143156409801 1094 6708572 An anti ulcer agent
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.661330450204654 0.221237132700457 no 768 0.25420020885585 1232 688803
SGTC_301 4119-0100 24.5 µM 0.66059520254336 0.221488902224943 no 769 0.254435973237103 1251 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3119 9125183 49.47 µM 0.659899654683879 0.221727228109117 no 770 0.254659112917303 1118 22695334
SGTC_1524 corynanthine 62.1 µM 0.659553299610055 0.221845959510101 no 771 0.254770265783344 1295 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_261 5-fluorouridine 15.376 µM 0.659083656932044 0.222007012204397 no 772 0.254921024880492 1274 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1560 lithocholic acid 53.1 µM 0.658287542726998 0.222280172909027 no 773 0.255176690582956 1203 9903 A bile acid which acts as a detergent.
SGTC_2623 humulene 100 µM 0.65825538839125 0.222291209651371 no 774 0.255187019506874 1202 6187145 An anti-inflammatory.
SGTC_3020 9089140 49.47 µM 0.657997337541627 0.22237979505472 no 775 0.255269920991239 1258 17217859
SGTC_3028 9087778 49.47 µM 0.657790526375955 0.222450805094072 no 776 0.255336371363463 1211 17217395
SGTC_3203 9113543 49.47 µM 0.656815134573413 0.222785886862575 no 777 0.255649895760285 1296 17018012
SGTC_2998 9066762 71.4286 µM 0.656140665261197 0.223017759163723 no 778 0.255866810856869 1304 4945196
SGTC_3132 9126706 49.47 µM 0.656046682582361 0.223050079887168 no 779 0.255897044112842 1269 850858
SGTC_1787 fluconazole 80 µM 0.654982559355959 0.223416218806946 no 780 0.256239491560426 1180 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_3151 9099821 49.47 µM 0.6537495182009 0.223840905645117 no 781 0.256636597404461 1219 17174189
SGTC_3262 9137218 49.47 µM 0.653730544667595 0.223847444135007 no 782 0.256642710409508 1133 17650664
SGTC_3190 9110366 49.47 µM 0.651736864698961 0.224535093050919 no 783 0.257285468329167 1190 17123768
SGTC_187 1488-2104 32.728 µM 0.651704058883467 0.224546418263098 no 784 0.257296051842961 1298 2852859
SGTC_2256 7954252 200 µM 0.651258460848483 0.224700279555686 no 785 0.25743982903515 1215 2972920
SGTC_1122 capsaicin 818.572 nM 0.650263024442985 0.225044211355035 no 786 0.257761168443173 1312 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2350 9023895 38.85 µM 0.650130196715028 0.225090127019843 no 787 0.257804062644958 1290 2997209
SGTC_78 0336-0123 156.75 µM 0.649167656999957 0.225423014680332 no 788 0.258115007290623 1174 6765896
SGTC_3178 9107506 49.47 µM 0.64861188646898 0.225615350903864 no 789 0.258294635279968 1294 8897194
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.64798952604662 0.225830842150832 no 790 0.258495862342874 1241 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2329 6138490 200 µM 0.646189982620564 0.226454585478208 no 791 0.259078163096345 1295 720019
SGTC_1841 st054148 70 µM 0.645043636276046 0.226852429558392 no 792 0.259449454041682 1221 675442
SGTC_2409 alverine citrate 63.97 µM 0.644591210045588 0.227009554336553 no 793 0.259596066303964 1391 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1717 st033143 58.0435 µM 0.643530232906603 0.227378265602436 no 794 0.259940051948185 1314 674616
SGTC_2591 skatole 100 µM 0.643091610886677 0.227530794243177 no 795 0.260082328829962 1288 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1779 st039427 55 µM 0.641219593946404 0.228182426237489 no 796 0.260690010501567 1342 1124498
SGTC_1554 st069299 38.7 µM 0.640126269444668 0.228563487331349 no 797 0.261045255919848 1273 24207999
SGTC_2950 9072895 21.46 µM 0.639838909310658 0.228663701482088 no 798 0.261138666896267 1233 17332245
SGTC_1061 3448-9325 110 µM 0.638890109339848 0.228994761736665 no 799 0.261447211357671 1250 723482
SGTC_2254 7938975 95.19 µM 0.638480387326057 0.229137807185558 no 800 0.26158050852199 1353 2969277
SGTC_48 0382-0018 55 µM 0.638395933628997 0.229167298568962 no 801 0.26160798865327 1377 762596
SGTC_2034 5197015 53.07 µM 0.637403913263139 0.229513873188223 no 802 0.261930890024215 1335 780676
SGTC_881 0833-0569 170 µM 0.637391506325253 0.229518209564573 no 803 0.261934929760322 1261 5418700
SGTC_2805 7950783 58.44 µM 0.635929610335595 0.230029481348791 no 804 0.26241115101922 1295 1178958 YDL195W SEC31
SGTC_2301 7769476 200 µM 0.635795255192184 0.230076501596794 no 805 0.262454940234809 1314 977820
SGTC_2420 aureobasidin a 50 nM 0.634277332101846 0.230608102342282 no 806 0.262949923598812 1405 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1626 st003712 1.76 µM 0.633835529679965 0.230762957413779 no 807 0.263094081676035 1273 24207035
SGTC_1121 fusaric acid 630.51 nM 0.632635661016214 0.231183813338529 no 808 0.263485796918748 1298 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_956 1185-0240 191 µM 0.6318574023177 0.231457017679328 no 809 0.263740030282339 1315 1416193
SGTC_1304 1165-0502 251 µM 0.631592540944586 0.231550037156578 no 810 0.263826580934264 1301 767425
SGTC_2116 5511452 16.8835 µM 0.631373803215481 0.231626873690398 no 811 0.263898070349167 1308 870744
SGTC_3176 9106582 49.47 µM 0.631081711429512 0.231729499635762 no 812 0.263993549252181 1210 17018027
SGTC_2386 9075165 157.42 µM 0.63035961794728 0.23198331463617 no 813 0.26422966255407 1266 16452277
SGTC_1969 st069479 40.1 µM 0.630237531959185 0.232026243009134 no 814 0.264269593393226 1300 3895485
SGTC_2070 5230947 200 µM 0.630047157401571 0.23209319211199 no 815 0.264331865603674 1346 2835538
SGTC_984 1492-0255 2.91 µM 0.628907979389817 0.23249403194828 no 816 0.26470465091034 1280 1585198
SGTC_2711 st079103 59.1 µM 0.628730733483311 0.232556433630494 no 817 0.264762676995012 1292 54693780
SGTC_65 0798-0905 34.986 µM 0.628201028926061 0.232742978365112 no 818 0.264936128177313 1486 3602145
SGTC_2478 5763493 32.33 µM 0.627271697238193 0.233070459628044 no 819 0.265240576294841 1269 1365576 YLR208W SEC13
SGTC_1153 4055-0057 267 µM 0.625927515265121 0.233544579672674 no 820 0.265681242989973 1283 882706
SGTC_3116 9124943 49.47 µM 0.625526643031947 0.233686078854725 no 821 0.265812733808745 1220 41905195 YPL160W CDC60
SGTC_2367 9070478 135.38 µM 0.624718524691936 0.23397147148202 no 822 0.266077906382566 1304 572802
SGTC_3136 9095672 49.47 µM 0.623646640032477 0.234350312739957 no 823 0.266429836713162 1167 17217380
SGTC_2144 5628481 200 µM 0.623512572351761 0.234397720787829 no 824 0.266473871523101 1289 2818399
SGTC_1871 st057448 67.3 µM 0.623341236881565 0.234458314927123 no 825 0.266530152374611 1397 691747
SGTC_1886 st057356 49.9 µM 0.622504861664317 0.234754229990075 no 826 0.266804973992 1248 24207747
SGTC_1873 rapamycin 2 nM 0.622327421129583 0.234817036159285 no 827 0.266863296965752 1309 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_67 0335-0847 266 µM 0.622110277950938 0.234893907959924 no 828 0.266934678575 1441 4552207 YOR254C SEC63
SGTC_1232 0279-0259 161 µM 0.621191221094562 0.235219421225479 no 829 0.267236907453485 1325 1560000
SGTC_2128 5255449 168.493 µM 0.620701989180122 0.235392799829377 no 830 0.267397860189564 1290 736008
SGTC_862 0452-0056 10.2 µM 0.620630727590874 0.235418060065122 no 831 0.267421308666995 1259 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_299 1273-0059 1.44 µM 0.620035580136922 0.235629081563512 no 832 0.267617181187774 1287 2848077
SGTC_2560 caryophyllene 100 µM 0.617303719333819 0.236599055118203 no 833 0.268517207029506 1343 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2582 agaric acid 100 µM 0.616561414917973 0.236862996533992 no 834 0.268762025739973 1227 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2001 4023502 57.655 µM 0.616425508644148 0.236911338297965 no 835 0.268806860998797 1347 108941 YCR052W RSC6
SGTC_925 2064-1272 59.6 µM 0.615429824386857 0.237265667849419 no 836 0.269135450150884 1294 6815817
SGTC_3042 9091578 49.47 µM 0.614570844708866 0.237571582688182 no 837 0.269419086797556 1284 25236497
SGTC_1021 4476-0760 85.3 µM 0.614492137255369 0.237599624182118 no 838 0.269445083633823 1286 746768
SGTC_120 rhodamine 6G 52.259 µM 0.614335041081358 0.237655599043494 no 839 0.269496975789099 1320 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1474 0330-0125 5.35 µM 0.612933733805809 0.238155218132137 no 840 0.26996007841476 1323 X1474
SGTC_2744 captopril 92.04 µM 0.612727371337042 0.238228842751634 no 841 0.270028310506143 1338 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.612088548030126 0.238456836879132 no 842 0.270239586985144 1327 23665772 A membrane-active detergent.
SGTC_1186 1319-0216 26 µM 0.611242739464264 0.238758887137486 no 843 0.270519446311426 1377 4565136
SGTC_1899 st063254 59.6 µM 0.610170682669932 0.239142034449391 no 844 0.270874374120229 1262 3093813
SGTC_332 4112-0506 40.9 µM 0.609933974874703 0.239226677803585 no 845 0.270952772714136 1337 2790355
SGTC_98 0074-0023 107.663 µM 0.609142260035924 0.23950990271634 no 846 0.271215074151577 1283 3563821
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.607408431123662 0.240130794744228 no 847 0.271789947311957 1402 165506
SGTC_2474 5321570 43.32 µM 0.606426926060795 0.240482664708574 no 848 0.272115646454346 1386 2841384
SGTC_936 3005-4620 401 µM 0.605813111865873 0.240702859973846 no 849 0.272319430938745 1416 777207
SGTC_381 3461-2219 42.7 µM 0.60578220112324 0.240713951571507 no 850 0.272329695218142 1332 2883159
SGTC_2152 5568786 200 µM 0.60527959664137 0.240894338471195 no 851 0.272496617974363 1307 5399883
SGTC_2227 7312221 64.1025 µM 0.605237334770626 0.240909509788337 no 852 0.272510656113368 1339 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_534 k292-0788 63.4 µM 0.605177183862987 0.24093110387204 no 853 0.272530637078665 1384 4146317
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.603556900902604 0.241513178931089 no 854 0.273069137196965 1373 676296 Flavone; oxidizing agent.
SGTC_919 tnp00227 403.569 nM 0.60274509129818 0.24180510264915 no 855 0.27333913983316 1355 1269246 A methoxyflavone. YNL221C POP1
SGTC_1565 sinapyl alcohol 95.1 µM 0.602458170283228 0.241908324158809 no 856 0.273434599523772 1296 5280507 A phenol propionate derived from cinnamic acid.
SGTC_3021 9087658 49.47 µM 0.601816863029897 0.242139124586852 no 857 0.273648024492812 1314 25237042
SGTC_650 1328-0195 38 µM 0.601694556103924 0.242183155246939 no 858 0.273688737196412 1328 2780821
SGTC_88 0180-0332 8.668 µM 0.600648672206479 0.242559852068596 no 859 0.274037006285198 1367 3101745
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.598950605505628 0.243172121275255 no 860 0.274602911859595 1338 688798
SGTC_3201 9113999 49.47 µM 0.598661239409506 0.243276540813302 no 861 0.274699404800381 1398 16649224
SGTC_3100 9120536 49.47 µM 0.598651085026723 0.24328020552498 no 862 0.274702791216873 1259 16421196
SGTC_2092 5303694 80.6725 µM 0.597572716026633 0.2436695581492 no 863 0.275062536957699 1318 1963699
SGTC_1243 0416-0003 5.65 µM 0.59614606870791 0.244185175643936 no 864 0.275538825229165 1332 2141977
SGTC_922 1866-0035 480 µM 0.595410323688104 0.244451317646537 no 865 0.275784613196027 1383 3156169
SGTC_2060 5238662 140 µM 0.595250407158559 0.244509185130566 no 866 0.275838050246415 1327 790130
SGTC_828 2074-0507 139 µM 0.591524737309654 0.245859444398123 no 867 0.277084442707438 1428 X828
SGTC_2316 5844804 197.44 µM 0.590784704303623 0.246128123190652 no 868 0.277332342422079 1388 776813
SGTC_1452 4194-0072 190 µM 0.590434045759977 0.246255489390231 no 869 0.277449845518573 1445 1343545
SGTC_1878 temozolomide 1 mM 0.590173660051947 0.246350089547291 no 870 0.277537114594262 1359 5394 DNA alkylating agent.
SGTC_3048 9093155 49.47 µM 0.589002635216589 0.246775772678399 no 871 0.277929752924811 1319 25236002
SGTC_1285 0929-0069 65.5 µM 0.588812801619401 0.246844816796189 no 872 0.277993428636618 1368 1206237
SGTC_1042 0350-0096 82 µM 0.588423571853707 0.24698641535179 no 873 0.278124009882173 1337 3122515
SGTC_3263 9137018 49.47 µM 0.588052979360922 0.247121274202008 no 874 0.278248366375289 1287 43844957
SGTC_560 2332-1943 155 µM 0.58655951776669 0.247665144797547 no 875 0.27874978885227 1354 21177716
SGTC_2311 7694451 200 µM 0.584005206246178 0.248596822456764 no 876 0.279608404662133 1394 2163142
SGTC_1084 voriconazole 435 nM 0.58340556445814 0.248815810329125 no 877 0.279810156400886 1366 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1277 0873-0036 22 µM 0.582645093663274 0.24909368024624 no 878 0.28006612118991 1448 5965735
SGTC_1329 1447-1697 50.6 µM 0.581994238301694 0.249331628603187 no 879 0.280285280913868 1351 2840515
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.580274016166591 0.249961111580578 no 880 0.280864923485635 1285 641818 YHR062C RPP1
SGTC_1164 k060-0068 93.7 µM 0.579813612736365 0.250129730525233 no 881 0.281020158342378 1385 5963676
SGTC_1783 st039459 87.517 µM 0.579565533310482 0.250220612569226 no 882 0.281103820806962 1481 729761
SGTC_3299 9121982 43.1275 µM 0.579062913736952 0.250404797160732 no 883 0.281273361426926 1373 17594604 YPL160W CDC60
SGTC_504 lovastatin 124 µM 0.578992242349754 0.250430700402277 no 884 0.28129720383346 1331 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2021 4019055 173 µM 0.578708756861635 0.250534620843254 no 885 0.281392853140172 1379 44827708 YER133W GLC7
SGTC_854 0422-0053 192 µM 0.578318077722823 0.250677873890792 no 886 0.281524695792247 1357 3596728
SGTC_1178 0988-0033 191 µM 0.578277047804204 0.250692921134407 no 887 0.281538543904919 1387 5392207
SGTC_393 acivicin 6.25 µM 0.577634740616643 0.250928542141537 no 888 0.281755373468158 1338 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2986 9022445 71.43 µM 0.575381346183938 0.251756092975408 no 889 0.282516708534659 1383 6459286
SGTC_2802 7925815 54.55 µM 0.574723671108146 0.251997893127706 no 890 0.282739097904656 1355 1262923
SGTC_2717 st081029 62.2815 µM 0.574584420599919 0.252049105544179 no 891 0.282786195519457 1341 5292846
SGTC_1792 st045773 43.6 µM 0.57439931868548 0.252117189316785 no 892 0.282848806932218 1353 2919270
SGTC_2794 7785382 27.27 µM 0.574037278717372 0.252250382086742 no 893 0.282971287544542 1363 2205081
SGTC_2921 7974240 10.71 µM 0.572829261050893 0.252695074306722 no 894 0.283380152357785 1424 2979074 YDR527W RBA50
SGTC_3142 9086498 49.47 µM 0.57179163853547 0.253077370473374 no 895 0.283731571322543 1319 25236367
SGTC_886 0866-0150 153 µM 0.571741045188652 0.253096018595452 no 896 0.28374871146413 1445 271463
SGTC_2419 paclitaxel 166.5 µM 0.571296041270885 0.253260073023407 no 897 0.283899492369405 1302 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1933 st074711 15.9 µM 0.569103392352247 0.254069227190261 no 898 0.284642988169355 1345 17250958
SGTC_1906 st060206 94.7 µM 0.568757936695953 0.254196834390568 no 899 0.28476021194277 1368 5133468
SGTC_707 0865-0008 204 µM 0.568670693695853 0.254229066229408 no 900 0.284789819830708 1448 723043
SGTC_255 tunicamycin 200.472 nM 0.567210704340674 0.254768775674448 no 901 0.285285518148554 1388 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1477 0139-0234 16 µM 0.567135286419926 0.254796671452726 no 902 0.285311135343044 1385 620880
SGTC_2819 7996655 46.38 µM 0.566898537280921 0.254884251232237 no 903 0.28539155900786 1363 6456960
SGTC_1852 st056254 31.4 µM 0.56681777866603 0.254914129587076 no 904 0.285418995172578 1396 442583
SGTC_2721 ifenprodil 61.44 µM 0.564614003338742 0.255730169723232 no 905 0.286168169213563 1415 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2137 5261020 140 µM 0.564073701774343 0.255930446996568 no 906 0.286351987354213 1350 763655
SGTC_357 1325-0123 420 µM 0.562641735342227 0.256461639414116 no 907 0.286839433276152 1401 1098503
SGTC_1736 st036774 51 µM 0.562011066251792 0.256695770152576 no 908 0.28705423970015 1443 1272247
SGTC_1008 4106-0037 6 µM 0.561471171707642 0.256896289960918 no 909 0.287238188737437 1391 2905394
SGTC_648 0375-0473 33.3 µM 0.558403930425078 0.258037025261273 no 910 0.288284294759192 1408 1713139
SGTC_3322 9139058 2.11 µM 0.557914242568905 0.258219387575226 no 911 0.288451472713026 1455 4908926 YPR165W RHO1
SGTC_647 0140-0236 81 µM 0.557270218617106 0.258459327126631 no 912 0.288671410083184 1435 990837
SGTC_1293 1000-1278 195 µM 0.555900859672706 0.258969883302978 no 913 0.289139315262548 1456 678847
SGTC_2202 7226349 200 µM 0.55571345973582 0.259039794653749 no 914 0.289203376899636 1367 844334
SGTC_1596 piperlongumine 63 µM 0.5537723398984 0.259764521803273 no 915 0.289867330213772 1494 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2024 5144227 134 µM 0.553742556021346 0.259775649912881 no 916 0.289877523252604 1441 3475211
SGTC_177 1327-0068 8.361 µM 0.552707040022743 0.260162701251176 no 917 0.290232015943628 1390 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_943 3253-1379 105 µM 0.551419151547476 0.260644497842601 no 918 0.290673187538275 1469 668464
SGTC_3112 9123419 49.47 µM 0.55140739403565 0.260648898419549 no 919 0.290677216567697 1425 17015854
SGTC_1048 3161-0300 24.5 µM 0.550404136600178 0.261024536313009 no 920 0.291021106030598 1385 2165101
SGTC_778 3456-2434 196 µM 0.550391477739839 0.261029277798829 no 921 0.291025446358878 1544 5539063
SGTC_2702 st077768 96.8 µM 0.547601742581708 0.262075276366466 no 922 0.291982696316589 1371 6484119
SGTC_817 1391-0715 46 µM 0.546182913691639 0.262608082791391 no 923 0.292470104964382 1389 1353946
SGTC_2068 5226020 147 µM 0.544765052332026 0.263141079082615 no 924 0.292957558710127 1392 1810509
SGTC_1725 st036284 20.55 µM 0.544396439407574 0.263279736923035 no 925 0.293084347734118 1560 707914
SGTC_1230 0170-0365 3.77 µM 0.543671584612743 0.26355250788586 no 926 0.293333744807882 1476 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_338 4055-0136 114 µM 0.543584223718709 0.263585392501999 no 927 0.293363809262473 1377 2900563
SGTC_2622 2-methoxyxanthone 59.94 µM 0.543402539674477 0.263653789188955 no 928 0.293426338740601 1518 71034 A hepatoprotective.
SGTC_2746 daunorubicin 9.88 µM 0.542830519715732 0.263869190655964 no 929 0.293623248895548 1374 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2583 asiatic acid 100 µM 0.542750959955651 0.263899157011516 no 930 0.293650641114998 1414 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2385 9074692 200 µM 0.542503263225346 0.263992463627134 no 931 0.293735930031458 1394 17046906
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.541156092523893 0.264500233006416 no 932 0.294199999198947 1415 165521
SGTC_858 0438-0351 2.77 µM 0.540153753681779 0.264878352126225 no 933 0.294545501379504 1407 2799119
SGTC_489 paxilline 115 µM 0.537149814623662 0.266013191697036 no 934 0.295582066807009 1366 105008 A toxic potassium channel blocker.
SGTC_1768 st044301 37.178 µM 0.536116297810336 0.266404206288456 no 935 0.295939088506892 1396 3931349
SGTC_1678 st019265 80.2 µM 0.535202533696525 0.266750156396626 no 936 0.296254907231956 1550 5367020
SGTC_1427 4048-4900 550 nM 0.532984661980602 0.26759078353326 no 937 0.297022098899917 1491 24132586
SGTC_1621 st003705 32.4 µM 0.531170130089802 0.26827952696678 no 938 0.297650444914135 1523 24207032
SGTC_3025 9087895 49.47 µM 0.531165239201573 0.268281384609856 no 939 0.297652139377075 1468 17173641
SGTC_3170 9103054 49.47 µM 0.53061705367041 0.268489635857904 no 940 0.297842087793593 1371 16432970
SGTC_2383 9036125 200 µM 0.530077437231014 0.268694711121117 no 941 0.298029120957356 1446 79580
SGTC_3340 9146634 11.102 µM 0.529896916296206 0.268763333670428 no 942 0.298091702163733 1435 4907387
SGTC_590 k048-0076 22.4 µM 0.529274054933061 0.269000173416794 no 943 0.298307675514682 1495 6832814
SGTC_3040 9091894 49.47 µM 0.529202647387833 0.269027332451181 no 944 0.298332440193324 1409 25236966
SGTC_450 aminopyrene 156 nM 0.528099242672025 0.269447174541569 no 945 0.298715228225094 1477 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_218 alverine citrate 93.75 µM 0.527569073476774 0.269649019034801 no 946 0.298899231434716 1486 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2930 9013230 14.89 µM 0.526138437723126 0.270194064271137 no 947 0.299396011882096 1519 2995857
SGTC_2953 9074162 66.49 µM 0.524046272600743 0.270992130504345 no 948 0.300123178107041 1538 16451992
SGTC_1546 5-methoxyflavanone 78.7 µM 0.522963073499944 0.271405783440052 no 949 0.30049997523933 1508 147795
SGTC_945 3381-0768 11.3 µM 0.522391056572641 0.271624352580691 no 950 0.300699040832405 1445 1126236 YIL048W NEO1
SGTC_3260 9137109 49.47 µM 0.518615866444007 0.27306905662602 no 951 0.302014321204677 1486 17478346
SGTC_2338 7999974 200 µM 0.518308552676573 0.273186828046376 no 952 0.302121503298769 1518 315925
SGTC_2625 euphol 100 µM 0.517051691808122 0.273668754845377 no 953 0.302560037401969 1566 6708538 A triterpene alcohol.
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.516057975508138 0.274050079809213 no 954 0.302906958975655 1528 5024745
SGTC_2537 larixol 68.93 µM 0.514812551999467 0.274528364379107 no 955 0.303342006633103 1484 6708759
SGTC_2114 5491910 81.25 µM 0.51407399330349 0.274812190191154 no 956 0.303600129600322 1533 2849228
SGTC_3125 9127534 49.47 µM 0.513804125888454 0.274915935471858 no 957 0.303694471514612 1408 1639235
SGTC_2638 epoxomicin 18 µM 0.511145703896134 0.275938944389682 no 958 0.304624517442951 1542 9915668 A protesome inhibitor.
SGTC_2423 st077119 87.2 µM 0.509291922358527 0.276653417926721 no 959 0.30527380951434 1407 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2082 5219693 150 µM 0.508700168399724 0.276881678983172 no 960 0.305481202174884 1443 2834649
SGTC_3155 9099265 49.47 µM 0.508181138358332 0.277081963669311 no 961 0.305663158606952 1489 25236499
SGTC_3075 9116269 49.47 µM 0.505660379513124 0.278055687908104 no 962 0.306547543357722 1511 17015205 YNL244C SUI1
SGTC_536 3852-0578 10.6 µM 0.505435670810946 0.278142569852045 no 963 0.30662643513211 1569 2869208
SGTC_1866 st057638 64 µM 0.503995209906732 0.278699827586602 no 964 0.307132371536429 1480 688802
SGTC_1373 2887-0003 58.5 µM 0.502034229293319 0.279459326520085 no 965 0.307821721714626 1484 776948
SGTC_791 1348-1292 225 µM 0.500168815951957 0.280182743336276 no 966 0.308478106991272 1502 5437054
SGTC_3258 9138477 49.47 µM 0.499823225435499 0.280316864653375 no 967 0.308599777671002 1524 4970355
SGTC_651 3253-0966 34.4 µM 0.499140583750268 0.28058188455841 no 968 0.308840174369366 1454 781462
SGTC_3071 9117417 49.47 µM 0.499037601353198 0.280621875623418 no 969 0.308876447402513 1515 45595590 YGL055W OLE1
SGTC_816 0325-0417 81.3 µM 0.496052927595352 0.281782107966171 no 970 0.309928534590736 1465 68101
SGTC_2017 5132927 60.65 µM 0.494985047165247 0.282197786043002 no 971 0.310305337760104 1448 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_656 4090-1979 187 µM 0.493966735383477 0.282594443972733 no 972 0.310664836132514 1581 22330961
SGTC_1968 st069590 43.6 µM 0.49396456142267 0.282595291071498 no 973 0.31066560380752 1531 6384066
SGTC_749 1000-0129 128 µM 0.493882111171077 0.282627419279501 no 974 0.310694719475155 1615 708470
SGTC_237 nikkomycin 200 µM 0.493676965094031 0.28270736571715 no 975 0.310767167879599 1570 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_471 1-acyl-paf 4 µM 0.493289563895411 0.282858367503313 no 976 0.310904000638322 1412 16759367
SGTC_1927 st060202 13.8 µM 0.492960336281979 0.28298672474735 no 977 0.311020306644367 1515 688887
SGTC_1082 camptothecin 424.86 nM 0.491164670003217 0.283687299841365 no 978 0.311654992416553 1362 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1652 st011932 78 µM 0.488679382057656 0.284658297544226 no 979 0.312534351458527 1560 1551076
SGTC_2782 7736369 71.43 µM 0.484908678993849 0.286134527368491 no 980 0.313870562828723 1509 2950836 YOL077C BRX1
SGTC_139 0099-0334 718.624 µM 0.484135449652516 0.28643769532303 no 981 0.314144872135583 1518 97690
SGTC_3101 9120531 49.47 µM 0.483396089042355 0.286727726506933 no 982 0.314407262297043 1556 24824904
SGTC_2603 homopterocarpin 100 µM 0.482134892621719 0.287222780830247 no 983 0.314855062091878 1513 101795 A weak amylase inhibitor.
SGTC_3065 9113888 49.47 µM 0.480172534943575 0.287993863695467 no 984 0.315552357271776 1555 16648368
SGTC_2012 4023501 200 µM 0.478184792987845 0.288775915800767 no 985 0.316259342535166 1471 3477460
SGTC_2612 dictamnine 15.46 µM 0.477881826290271 0.288895201996462 no 986 0.316367158574118 1519 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2887 9044784 58.44 µM 0.477355461462786 0.289102501210709 no 987 0.3165545118919 1480 6465546
SGTC_1846 st056244 14.8 µM 0.476133782539213 0.289583906640356 no 988 0.316989535395103 1547 5393182
SGTC_1120 ficusin 1.78878 µM 0.475021265087649 0.290022623885766 no 989 0.317385908177061 1628 6199 A DNA cross-linker.
SGTC_705 1124-0212 310 µM 0.473616517151593 0.290577025848849 no 990 0.317886697429398 1602 9554485
SGTC_145 3737-0113 38.366 µM 0.4727101657932 0.290934992125466 no 991 0.318209986445564 1583 6849351
SGTC_3024 9090631 49.47 µM 0.472502467046244 0.291017052403153 no 992 0.318284090614981 1540 25236383
SGTC_2249 haloperidol 116.36 µM 0.472014883143734 0.291209735764276 no 993 0.318458082683393 1564 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2 0422-0095 29 µM 0.470691350695551 0.291733069239331 no 994 0.318930580945064 1447 6790840
SGTC_3144 9087057 49.47 µM 0.469462617063831 0.292219310598476 no 995 0.319369499812024 1631 17249618
SGTC_2182 6325192 200 µM 0.468343563803042 0.292662476410234 no 996 0.319769459865549 1492 736248
SGTC_1868 st057644 42.7 µM 0.467043282080484 0.293177803817154 no 997 0.32023445599066 1502 688665
SGTC_1076 itraconazole 331 nM 0.466367560267403 0.293445771788329 no 998 0.320476213681995 1528 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_189 3970-0742 2.116 µM 0.465980795514315 0.293599200390787 no 999 0.320614623490988 1565 2891807
SGTC_2743 auranofin 4.32 µM 0.465443139427377 0.29381254888545 no 1000 0.320807073562475 1558 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1508 1080-0625 72.9 µM 0.464651563008324 0.294126786530969 no 1001 0.321090500210117 1517 767111
SGTC_1998 st075797 76.8 µM 0.463553353422291 0.294563007518654 no 1002 0.321483890555891 1559 24208315
SGTC_2136 5328288 199.296 µM 0.462884346609001 0.294828890649758 no 1003 0.321723634114194 1505 262395
SGTC_845 0330-0138 4.51 µM 0.461939941379758 0.295204413473675 no 1004 0.322062195114706 1618 9039800
SGTC_3267 9137951 49.47 µM 0.461535804003294 0.295365177425704 no 1005 0.3222071199732 1564 16643986
SGTC_227 fluconazole 33.516 µM 0.45945781900631 0.296192425418945 no 1006 0.322952718002327 1496 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1913 st060213 96.1 µM 0.458833449216698 0.296441195182841 no 1007 0.323176886255855 1655 688959
SGTC_1597 7-benzyloxygramine 47.5 µM 0.458027674451151 0.296762384208359 no 1008 0.323466279483239 1510 260807
SGTC_877 0771-0151 33.1 µM 0.457213078475207 0.297087251295911 no 1009 0.323758949425092 1584 6166523
SGTC_2304 7443016 91.4 µM 0.457082663805084 0.297139276759095 no 1010 0.323805815240273 1518 939854
SGTC_2890 9046729 58.44 µM 0.456933802811122 0.29719866598258 no 1011 0.323859313340713 1467 903329
SGTC_109 0132-0036 33.701 µM 0.452837837381933 0.298834906443304 no 1012 0.325332757764445 1495 67274 A color developer.
SGTC_939 1165-0479 45.3 µM 0.452546194246694 0.298951566866689 no 1013 0.325437775300751 1547 1377347
SGTC_512 prima-1 270 µM 0.451019064635777 0.299562772757976 no 1014 0.325987904301966 1618 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1607 st000305 50.6 µM 0.45055968857347 0.299746740421004 no 1015 0.326153462885498 1597 5457690
SGTC_3060 1327-0027 12.5 µM 0.449646975032753 0.300112409193022 no 1016 0.326482505414459 1617 16000455 YPR107C YTH1
SGTC_208 k072-0098 12.366 µM 0.448080771141274 0.300740361459683 no 1017 0.32704745249493 1560 5948901
SGTC_245 methotrexate 289.6 µM 0.447666713942928 0.300906472189117 no 1018 0.327196873840978 1583 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1457 k015-0032 57.3 µM 0.447449339446118 0.300993694662088 no 1019 0.327275329140473 1542 4302660
SGTC_661 1304-0007 33.6 µM 0.447073956824846 0.301144345420448 no 1020 0.327410831059169 1526 3117130
SGTC_3250 9135583 49.47 µM 0.447043274955543 0.301156660350233 no 1021 0.327421907303532 1636 7699353
SGTC_2820 7989630 71.43 µM 0.446890462799807 0.301217998680762 no 1022 0.327477075200194 1589 2984098
SGTC_2508 celastrol 40.54 µM 0.446694137899174 0.301296811151783 no 1023 0.327547957498339 1497 122724 Celastrol is a natural product and antioxidant.
SGTC_1624 st003710 6.25 µM 0.446461488825109 0.301390217582653 no 1024 0.327631962537884 1642 24207033
SGTC_1759 st043059 70 µM 0.445326879572984 0.301845939287427 no 1025 0.328041772773033 1506 669426
SGTC_3194 9111903 49.47 µM 0.445164562103688 0.301911160255257 no 1026 0.328100417267196 1616 17087251
SGTC_3029 9088683 49.47 µM 0.440733116497256 0.303694204637061 no 1027 0.329703109442484 1574 25236615
SGTC_2813 7971799 71.43 µM 0.440494562405551 0.303790322875423 no 1028 0.329789474854463 1597 2234054
SGTC_3107 9121808 49.47 µM 0.43814141449285 0.304739179768149 no 1029 0.330641887198131 1583 662681
SGTC_3197 9113331 49.47 µM 0.437351441829881 0.305058014608107 no 1030 0.330928246928548 1678 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_876 0720-0963 56.8 µM 0.437280057847819 0.305086832648418 no 1031 0.330954128014697 1700 765861
SGTC_2288 7946289 167.31 µM 0.436956056331492 0.305217648734248 no 1032 0.33107160865553 1701 1246052
SGTC_2859 9028643 45.46 µM 0.436168193778851 0.305535853197566 no 1033 0.331357351382637 1615 17151580
SGTC_2773 thioridazine 9.09 µM 0.435573841022761 0.305775999559623 no 1034 0.331572976793133 1578 5452 An antipsychotic.
SGTC_1676 st018489 23.4 µM 0.435152231591292 0.305946400183371 no 1035 0.331725966453795 1583 3696235
SGTC_1310 1188-0297 994 nM 0.434767651302622 0.306101871488653 no 1036 0.331865543809227 1563 1588352
SGTC_1438 4092-1045 4 µM 0.434158876982049 0.306348047391871 no 1037 0.332086536563654 1545 1351342
SGTC_1609 st001574 46.4 µM 0.432985753811307 0.306822680978325 no 1038 0.332512559758137 1553 3960012
SGTC_637 1181-0519 7.26 µM 0.430050484605942 0.308011679181558 no 1039 0.333579458856978 1565 6252091 YGR060W ERG25
SGTC_688 0527-0193 473 µM 0.427930962172237 0.308871496120273 no 1040 0.334350692116124 1618 4007154
SGTC_2536 dehydroabietamide 32.04 µM 0.427581907037091 0.309013196393659 no 1041 0.334477770433552 1703 3983547
SGTC_3177 9107506 49.47 µM 0.425560906297893 0.309834187614618 no 1042 0.335213915962144 1666 8897194
SGTC_3157 9099274 49.47 µM 0.425538116151546 0.309843451077407 no 1043 0.335222220844174 1662 17217662
SGTC_1789 tunicamycin 25 nM 0.422716358234565 0.310991336535961 no 1044 0.33625110956049 1559 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_988 1497-1057 103 µM 0.421038296249992 0.311674842723115 no 1045 0.336863558733802 1680 3533044
SGTC_2555 cholic acid 100 µM 0.420888998806851 0.311735685867155 no 1046 0.336918069424854 1627 6708657 Influences liver metabolism.
SGTC_352 k048-0007 5.11 µM 0.41851172529606 0.312705186988393 no 1047 0.337786507777825 1579 6811911
SGTC_1249 0481-0015 10.2 µM 0.418107795357803 0.312870047056344 no 1048 0.337934152871197 1553 4227577
SGTC_1172 0370-0043 85 µM 0.417820450706632 0.312987346763061 no 1049 0.338039198711619 1644 376585
SGTC_2647 atorvastatin 60.16 µM 0.415200361663598 0.314057790533048 no 1050 0.338997617042016 1657 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_168 3970-0862 530.542 µM 0.414852658261506 0.314199963520701 no 1051 0.339124884111043 1614 3135186
SGTC_2570 licareol 100 µM 0.414732253872533 0.314249202287899 no 1052 0.339168959037556 1566 443158
SGTC_879 0831-1030 162 µM 0.41286485345826 0.315013289034199 no 1053 0.33985281636808 1585 1549252
SGTC_3106 9121286 49.47 µM 0.412307074407818 0.315241670065197 no 1054 0.340057182016623 1668 15943471
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.41187178255781 0.31541994813401 no 1055 0.340216702021596 1672 140250 A respiratory chain inhibitor.
SGTC_888 0916-0002 6.97 µM 0.40937096246711 0.316445015384613 no 1056 0.341133722943603 1693 2802138 YIL048W NEO1
SGTC_762 1165-0429 115 µM 0.40824101735871 0.316908634885262 no 1057 0.341548368712862 1705 5967793
SGTC_1216 1165-0504 9.65 µM 0.407981536025065 0.317015141408043 no 1058 0.341643615265958 1705 6304004
SGTC_79 0052-0007 94.094 µM 0.407631794666115 0.317158719986688 no 1059 0.341772009082366 1707 2801472
SGTC_3153 9100258 49.47 µM 0.40657077710666 0.317594465634968 no 1060 0.342161631997674 1564 25236848
SGTC_893 0958-0369 48.9 µM 0.406501223666876 0.31762303913406 no 1061 0.342187179028043 1749 6819948
SGTC_1173 0443-0020 122 µM 0.404652050649487 0.318383102518299 no 1062 0.342866646216027 1599 5331295
SGTC_3195 9113082 49.47 µM 0.404432103528062 0.318473558097691 no 1063 0.342947498309529 1728 17018038
SGTC_110 0850-0284 111.64 µM 0.40403530084149 0.318636774767877 no 1064 0.343093380322447 1550 3906265
SGTC_1088 bifonazole 369 nM 0.40288583012301 0.319109784596115 no 1065 0.343516107955162 1612 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1840 st055363 71 µM 0.402875788617999 0.319113917997782 no 1066 0.34351980166747 1557 676033
SGTC_1763 st044482 94.5 µM 0.402819601333865 0.319137046879423 no 1067 0.34354047012618 1675 88505
SGTC_2747 doxorubicin 7.63 µM 0.401963861074429 0.319489389980135 no 1068 0.343855311451702 1663 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2654 protoveratrine a 100 µM 0.400146953982435 0.320238024845422 no 1069 0.344524141216703 1635 5702278 A heart drug and vasodilator.
SGTC_3059 1327-0034 3 µM 0.398783400667046 0.320800341940523 no 1070 0.34502640452019 1587 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2698 st077697 67.5 µM 0.397985896356007 0.321129416287824 no 1071 0.345320290985621 1560 3154499
SGTC_1938 st074717 56.4 µM 0.397585181209791 0.32129481650704 no 1072 0.345467992820143 1573 17250979
SGTC_1000 4048-0884 8.67 µM 0.396747652053894 0.321640631650903 no 1073 0.345776778343593 1664 13040088
SGTC_2442 5158906 48.48 µM 0.394335919856496 0.322637296744181 no 1074 0.346666523546219 1721 1893835
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.394178724908638 0.322702303007912 no 1075 0.346724545925684 1732 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_3259 9138485 49.47 µM 0.393723892802506 0.322890424404031 no 1076 0.346892449692042 1735 17646153
SGTC_121 0557-0495 61.343 µM 0.393550782154418 0.322962035958844 no 1077 0.346956362339231 1652 3104427
SGTC_289 k017-0060 526 µM 0.392075750921639 0.323572485576994 no 1078 0.347501121996882 1629 5512909
SGTC_1170 0310-0127 64.8 µM 0.391362279910908 0.323867929983424 no 1079 0.347764734797375 1685 774975
SGTC_334 1502-1024 68.5 µM 0.391343820543777 0.323875575379355 no 1080 0.347771556129691 1657 3296216
SGTC_2842 9000675 19.48 µM 0.390787695593344 0.324105942884536 no 1081 0.34797708535559 1538 2989072
SGTC_90 0870-0863 4.608 µM 0.388545485352832 0.325035431835869 no 1082 0.348806200164291 1620 1738164
SGTC_1398 3558-0053 112 µM 0.387527030467812 0.325457983899627 no 1083 0.34918303888543 1627 4532369
SGTC_2618 avocadyne 43.43 µM 0.386711372862727 0.325796558235068 no 1084 0.349484947831965 1722 3015189
SGTC_1119 parthenolide 318.541 nM 0.38643876634959 0.325909747540887 no 1085 0.349585872132238 1733 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1997 st073024 93.8 µM 0.385738500102255 0.326200579533733 no 1086 0.349845173210039 1733 686268
SGTC_2112 5488546 200 µM 0.385622396665978 0.326248809406928 no 1087 0.349888171839751 1620 600757
SGTC_438 sphingosine 6.67 µM 0.385554255472017 0.326277116908972 no 1088 0.34991340866437 1480 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2053 5265679 138 µM 0.385427284431593 0.326329866423558 no 1089 0.34996043552455 1589 764595
SGTC_2780 5215298 71.43 µM 0.38419979228573 0.326840001190679 no 1090 0.350415186128198 1796 2834131
SGTC_2567 aureobasidin a 60 nM 0.382957258033736 0.327356717157727 no 1091 0.350875727869046 1708 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1287 0971-0001 34.6 µM 0.381297951309784 0.328047266682697 no 1092 0.351491086829854 1689 4665869
SGTC_2281 7943571 200 µM 0.380917703110804 0.328205596547176 no 1093 0.351632157936876 1795 1244024
SGTC_1982 st072467 71.9 µM 0.380841497462575 0.32823733119358 no 1094 0.351660432495601 1619 3163533
SGTC_449 xestospongin c 11.1929 µM 0.379205365805473 0.328918971236191 no 1095 0.352267683642158 1712 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_715 0868-0130 184 µM 0.3784127246421 0.329249403801376 no 1096 0.352562008439974 1814 2876258
SGTC_3347 9188721 44.724 µM 0.377647255170328 0.329568635809888 no 1097 0.352846327609481 1693 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1409 3909-8004 61.9 µM 0.376050047502025 0.330235136433815 no 1098 0.353439844752862 1676 2119279
SGTC_793 0488-0545 106 µM 0.374381881027103 0.330931823065637 no 1099 0.354060110642461 1621 292548
SGTC_1383 3049-0032 20.7 µM 0.373467014861107 0.331314153193517 no 1100 0.354400445319713 1775 712864
SGTC_2642 cholecalciferol 100 µM 0.373333845097773 0.331369820611733 no 1101 0.354449994823976 1725 9821465 A vitamin D precursor, similar to steriods.
SGTC_63 0099-0242 26.702 µM 0.372688920029705 0.33163946388697 no 1102 0.354689991924621 1723 3898502 YLR359W ADE13
SGTC_783 0848-0141 92.7 µM 0.371418192334303 0.332171010599392 no 1103 0.35516303880118 1645 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_3140 9094243 49.47 µM 0.369898678522501 0.332807068294025 no 1104 0.355728993053104 1707 19291112
SGTC_1847 st056231 15 µM 0.368685819035228 0.333315108315511 no 1105 0.356180960019775 1626 5393180
SGTC_1200 1643-0193 18.4 µM 0.368684800559327 0.333315535061239 no 1106 0.356181339635546 1730 5403974
SGTC_1448 4255-0083 152 µM 0.366529489539701 0.334219102133052 no 1107 0.356985005916543 1809 5399660
SGTC_506 n9-isopropylolomoucine 153 µM 0.366249083072501 0.334336727215868 no 1108 0.357089609847156 1843 6610355
SGTC_198 3454-2873 16.191 µM 0.365927835504711 0.334471504343602 no 1109 0.357209462506331 1697 710957
SGTC_2914 7968218 45.32 µM 0.364194452474341 0.335199100630577 no 1110 0.357856404622619 1774 2977111
SGTC_1443 4112-3303 14 µM 0.360965465731474 0.336556132418505 no 1111 0.359062631690281 1680 704433
SGTC_3117 9124945 49.47 µM 0.360544606642695 0.3367331623622 no 1112 0.359219952553405 1596 17592065
SGTC_2487 5918373 44.05 µM 0.360384922187427 0.336800341417806 no 1113 0.359279650269069 1778 2876279
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.36020743912833 0.33687501443459 no 1114 0.359346005988595 1723 7104
SGTC_2324 6149169 200 µM 0.35793423243814 0.337831995694012 no 1115 0.36019626591557 1760 2888231
SGTC_530 4358-1714 28 µM 0.357296853874071 0.338100509814986 no 1116 0.360434792503721 1745 1564641
SGTC_2663 amphotericin b 100 µM 0.356678181506126 0.338361222206019 no 1117 0.360666370619332 1699 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2429 5902844 64.44 µM 0.355702696138704 0.338772455233776 no 1118 0.361031612849474 1825 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1872 amphotericin b 148 nM 0.354512009444343 0.339274670701932 no 1119 0.361477602734713 1775 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_856 0433-0016 11.3 µM 0.353829289302115 0.339562761694711 no 1120 0.361733410962395 1691 3911780
SGTC_3076 9116187 49.47 µM 0.352548047340287 0.340103667082164 no 1121 0.362213645910028 1825 27241210
SGTC_3032 9089427 49.47 µM 0.350221261069218 0.341086814055062 no 1122 0.36308632595943 1680 17173707
SGTC_274 sirtinol 40.1 µM 0.349167946785113 0.341532230958207 no 1123 0.363481614191899 1637 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1362 1611-0397 101 µM 0.347916584065909 0.342061683891214 no 1124 0.363951415081563 1677 27816
SGTC_2517 totarol 10 µM 0.346059006022362 0.342848199886014 no 1125 0.364649185312446 1644 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2685 mycophenolic acid 18.85 µM 0.345134421557441 0.343239931912577 no 1126 0.364996658429357 1774 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3249 9135183 49.47 µM 0.343988356668751 0.343725735593806 no 1127 0.365427521208132 1756 4902779
SGTC_1702 st027038 51 µM 0.342979311135146 0.344153672116388 no 1128 0.365807012254792 1729 5521182
SGTC_3111 9122088 49.47 µM 0.341739683855318 0.344679671698227 no 1129 0.366273402364934 1805 16876704
SGTC_799 1310-0557 151 µM 0.341727909872369 0.344684669085343 no 1130 0.366277833087753 1730 5354492
SGTC_154 3389-1638 511.116 µM 0.341723047052502 0.344686733084125 no 1131 0.366279663043536 1594 5238686
SGTC_505 gw-5074 63.9 µM 0.341657159993122 0.34471469896191 no 1132 0.366304457682473 1790 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_892 0929-0076 29 µM 0.340325399492244 0.345280148777761 no 1133 0.36680574574244 1703 5751038
SGTC_2966 9084041 48.03 µM 0.340140652590468 0.345358617455694 no 1134 0.366875304303253 1543 17741380
SGTC_426 0988-0037 14.6 µM 0.339302600725724 0.345714651758544 no 1135 0.367190891821455 1891 5383008
SGTC_1486 3970-0793 4.53 µM 0.338710079583676 0.345966458249566 no 1136 0.367414073325451 1824 2844330
SGTC_74 000s-0487 160.283 µM 0.336237921397863 0.347017796992146 no 1137 0.368345729372369 1755 677548
SGTC_1340 1486-1359 257 µM 0.335676723023165 0.347256623186707 no 1138 0.368557330334327 1748 4309068
SGTC_391 gliotoxin 8.33 µM 0.335625137498231 0.347278579208898 no 1139 0.36857678276051 1772 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1659 st012954 42.1 µM 0.334908031354231 0.347583849638452 no 1140 0.368847231742765 1768 24207262
SGTC_970 1315-0089 19.5 µM 0.33459697250361 0.347716297428111 no 1141 0.368964564499064 1656 6811083 YLR033W RSC58
SGTC_228 caffeine 993.056 µM 0.334460011831617 0.347774620706628 no 1142 0.369016230535437 1795 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2850 9015429 58.44 µM 0.333790110795743 0.348059942979418 no 1143 0.369268973157218 1680 6457570
SGTC_281 1672-3440 14.9 µM 0.33278571407179 0.34848789383469 no 1144 0.369648021359094 1797 6833000
SGTC_796 1234-0020 70.7 µM 0.331905328810025 0.348863164882246 no 1145 0.369980373234848 1679 46495034
SGTC_1811 st050069 61.5 µM 0.331474697080004 0.349046778884368 no 1146 0.370142975251198 1833 3877702
SGTC_2118 5526350 200 µM 0.328357856589544 0.350376797773369 no 1147 0.371320551802636 1773 743594
SGTC_41 0478-0632 82.643 µM 0.327708351993228 0.350654186319368 no 1148 0.371566093923714 1902 3750424
SGTC_579 4491-1009 110 µM 0.327691754549037 0.350661275752076 no 1149 0.371572369193786 1916 1271041
SGTC_2767 sibutramine 71.45 µM 0.327492039644097 0.35074658605867 no 1150 0.371647881384836 1864 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1813 st051246 8.6015 µM 0.32733979212904 0.350811625229977 no 1151 0.37170544947707 1852 5291959
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.325293184755096 0.351686346626321 no 1152 0.37247959420818 1760 4000243
SGTC_1668 st014914 51.6 µM 0.324843975943475 0.351878444104813 no 1153 0.37264957994071 1752 2839556
SGTC_3316 9136639 10.545 µM 0.323405355789495 0.352493902926712 no 1154 0.373194136982529 1804 4903665
SGTC_3041 9091929 49.47 µM 0.323053363902325 0.352644548140545 no 1155 0.373327414157255 1784 25236887
SGTC_444 curcumin 90.4 µM 0.32102969899937 0.353511082414569 no 1156 0.374093942285619 1779 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2963 9082507 9 µM 0.320829960194456 0.353596651933622 no 1157 0.374169626834154 1786 16459611
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.320512622759161 0.353732616752882 no 1158 0.374289881546584 1816 5377381
SGTC_1815 st051655 58.2 µM 0.319753744137978 0.354057837751937 no 1159 0.374577507442407 1863 5984156
SGTC_2549 cedrol 20.94 µM 0.319159722826773 0.354312482695887 no 1160 0.374802698761388 1844 6708665 A sedative which affects the nervous system.
SGTC_3105 9121040 49.47 µM 0.318897590775832 0.354424874138907 no 1161 0.374902085651059 1843 41448907
SGTC_2273 7815444 169.05 µM 0.318205111598966 0.354721841692555 no 1162 0.375164677818712 1882 2824616
SGTC_983 1491-0821 12.2 µM 0.317496294358974 0.355025907237096 no 1163 0.375433525407625 1861 46495113
SGTC_2755 lomerizine 42.69 µM 0.316486902487791 0.355459071430237 no 1164 0.375816482484711 1701 3949 A calcium channel blocker.
SGTC_852 0418-0143 439 µM 0.316242406067204 0.355564021234441 no 1165 0.375909261346964 1856 5369229
SGTC_1867 st057372 64 µM 0.315593064267979 0.355842803594152 no 1166 0.376155701376637 1762 688837
SGTC_3216 9129716 49.47 µM 0.315532069415961 0.355868994519802 no 1167 0.376178852911227 1694 8056934
SGTC_3252 9135871 49.47 µM 0.315184965874417 0.356018052226951 no 1168 0.376310609881459 1819 17682838
SGTC_68 0986-0284 82.829 µM 0.315002137969285 0.356096573409651 no 1169 0.376380015289738 1624 423278 YIL048W NEO1
SGTC_2712 st079126 47.7 µM 0.314992901192727 0.356100540595272 no 1170 0.37638352187504 1739 3152970
SGTC_298 1391-0729 10 µM 0.313972703574972 0.356538810170798 no 1171 0.376770885302587 1750 3237558
SGTC_875 0709-0210 25.7 µM 0.313804154039357 0.35661123609754 no 1172 0.376834894589404 1901 6251364
SGTC_3215 9129942 49.47 µM 0.313767322266279 0.356627063440704 no 1173 0.376848882474344 1909 17682944
SGTC_2360 9040895 200 µM 0.312650969106557 0.357106899554022 no 1174 0.377272925098876 1723 4914414
SGTC_3114 9122766 49.47 µM 0.312598887337646 0.3571292911083 no 1175 0.377292711784265 1716 17176985
SGTC_1903 st060211 78.3 µM 0.31095924134339 0.357834476585665 no 1176 0.377915803617965 1876 688960
SGTC_2566 crystal violet carbinol 226 nM 0.310420909853562 0.358066110315327 no 1177 0.378120447604193 1644 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_7 0192-1582 4.227 µM 0.308746714336747 0.358786818222732 no 1178 0.378757102875193 1790 252616
SGTC_819 1013-0258 27.7 µM 0.308386664255419 0.358941878444229 no 1179 0.378894064105814 1760 5753198
SGTC_3126 9127922 49.47 µM 0.308247479674312 0.359001826314529 no 1180 0.378947013293538 1796 45595682
SGTC_1567 st069303 68.4 µM 0.307758946623083 0.359212268735315 no 1181 0.379132881080085 1765 5581319
SGTC_2049 5262831 67.185 µM 0.307249334064319 0.359431836974533 no 1182 0.379326798579359 1755 763417
SGTC_2682 pyrogallin 40.03 µM 0.307085388641648 0.359502483269353 no 1183 0.379389189462157 1821 822798 An ATP competetive kinase inhibitor.
SGTC_2831 7999036 19.48 µM 0.306694818733923 0.359670804456789 no 1184 0.379537836952675 1920 2988270
SGTC_2255 7941087 197.44 µM 0.306693791404738 0.359671247233592 no 1185 0.379538227968667 1888 935561
SGTC_1221 2958-7315 257 µM 0.306417978946729 0.359790128657866 no 1186 0.379643210539398 1797 4562705
SGTC_273 hydroxyurea 18.1 mM 0.306229492164259 0.359871378539869 no 1187 0.379714959418688 1801 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2546 rhodinyl acetate 100 µM 0.305976318867329 0.359980522419691 no 1188 0.379811338212127 1900 6708682
SGTC_2450 5739737 12.93 µM 0.304471525248556 0.360629479449491 no 1189 0.380384341581731 1770 2262825
SGTC_2472 5377652 49.4 µM 0.303795975973112 0.360920947437118 no 1190 0.380641666325528 1747 1610903
SGTC_628 1636-0253 16 µM 0.303241294378574 0.361160327068945 no 1191 0.380852990625404 1866 4456143
SGTC_2415 st077333 57.7 µM 0.302880982217134 0.361315853334132 no 1192 0.380990282510276 1987 2766255
SGTC_1406 3909-7906 11.9 µM 0.302593405427831 0.361440000326762 no 1193 0.381099870356605 1809 X1406
SGTC_2235 salicylic acid 500 µM 0.301344358062653 0.361979383632589 no 1194 0.381575959559081 1823 338 A COX inhibitor and kinase inhibitor.
SGTC_754 3474-0146 171 µM 0.300696962302139 0.362259060247809 no 1195 0.381822792689995 1669 24762078
SGTC_713 1488-1073 324 µM 0.300679889785016 0.362266436614539 no 1196 0.381829302593847 1900 3312542
SGTC_786 4544-0069 423 µM 0.299604915726199 0.362730993737953 no 1197 0.382239267065302 1840 748821 YLR208W SEC13
SGTC_1319 1306-0155 43.7 µM 0.299265571839123 0.362877685441666 no 1198 0.382368710597233 1806 3122360
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.298820994998917 0.363069897735327 no 1199 0.382538315380382 1771 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_859 0439-0102 54.6 µM 0.298147384237942 0.363361198301549 no 1200 0.382795338870502 1921 610143
SGTC_2325 6158266 200 µM 0.296923916130816 0.363890484756043 no 1201 0.38326229835363 1769 3623240
SGTC_3160 9100216 49.47 µM 0.296821744598633 0.36393469711013 no 1202 0.383301301714423 1871 17191039
SGTC_842 0271-0008 11.1 µM 0.29650901804596 0.364070033506901 no 1203 0.383420690522744 1855 1221709
SGTC_372 0155-0182 15.9 µM 0.295996096249154 0.364292043646441 no 1204 0.383616531317726 1845 771486
SGTC_1814 st052110 31.539 µM 0.295944629419865 0.364314322769991 no 1205 0.383636183723215 1894 674163
SGTC_2435 5706476 10.6 µM 0.295835939240226 0.364361374424462 no 1206 0.383677687622541 1934 5725375
SGTC_2283 7944793 200 µM 0.294482932691528 0.364947257809347 no 1207 0.384194451637288 1724 2970533
SGTC_3219 9131112 49.47 µM 0.294044363128214 0.365137236423848 no 1208 0.384362002062285 1832 17612988 YMR079W SEC14
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.292968300978185 0.365603502871884 no 1209 0.384773190641113 1823 97141
SGTC_1446 4239-0190 62 µM 0.292865577157432 0.365648024333436 no 1210 0.384812450607585 1762 1340085
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.292700197769087 0.365719705104334 no 1211 0.38487565935588 1839 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2690 usnic acid 100 µM 0.292652464927674 0.36574039493228 no 1212 0.38489390363229 1918 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2052 5265182 7.135 µM 0.291968727520921 0.366036804147353 no 1213 0.385155267258688 1891 1239884
SGTC_2041 5107442 45.335 µM 0.291757337801174 0.366128460580601 no 1214 0.385236083091182 1900 793005
SGTC_1522 st012842 45.6 µM 0.291385931010252 0.366289517288227 no 1215 0.385378086687853 1687 3491067 YOR116C RPO31
SGTC_3253 9135987 49.47 µM 0.288776605063711 0.367421687069401 no 1216 0.3863761680966 1833 4182430
SGTC_47 0149-0135 24.25 µM 0.287778265927813 0.367855165636537 no 1217 0.386758237594191 1672 5239155
SGTC_1802 st050112 57.9 µM 0.287033625999395 0.368178597733744 no 1218 0.387043286607127 1844 4662563
SGTC_2926 9010726 65.15 µM 0.287004198772381 0.368191381281687 no 1219 0.387054552635663 1740 2994293
SGTC_1203 3992-3522 103 µM 0.285495217623204 0.368847096505447 no 1220 0.38763238390148 1988 5322312
SGTC_403 arphamenine a 50 µM 0.284438441473949 0.369306537342164 no 1221 0.388037201487675 1834 5487158 An arginine aminopeptidase inhibitor.
SGTC_2213 7173844 200 µM 0.284098068019835 0.369454556876259 no 1222 0.388167613746087 1814 892728
SGTC_2055 5235184 200 µM 0.282733383098361 0.370048216880671 no 1223 0.38869061194113 1814 2836034
SGTC_2490 carminic acid 95.39 µM 0.28184713798282 0.370433913831886 no 1224 0.389030362299397 1828 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_706 4262-0057 46.9 µM 0.281436670335081 0.370612594946124 no 1225 0.389187747686619 1766 883298
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.278911956864894 0.371712243207599 no 1226 0.390156196138922 1820 521171
SGTC_3162 9099653 49.47 µM 0.278715354310468 0.371797918253301 no 1227 0.390231639118887 1899 25237511
SGTC_216 k038-0035 28.382 µM 0.276438352805949 0.372790646765714 no 1228 0.391105701318216 1915 4444231 YPR107C YTH1
SGTC_1248 0469-0687 58.6 µM 0.276339808433543 0.372833629335307 no 1229 0.391143541552383 1873 4017482
SGTC_2981 9013952 38.96 µM 0.273987209924188 0.373860242432692 no 1230 0.392047225352127 1700 2996344
SGTC_904 1141-0088 396 µM 0.273619621909085 0.374020729402544 no 1231 0.392188476584275 1762 1378119
SGTC_2866 9034245 58.44 µM 0.272469723987782 0.374522909610355 no 1232 0.392630433840677 1954 6462273
SGTC_379 3970-0972 5.9 µM 0.27223967713865 0.37462340061268 no 1233 0.392718867786933 1844 2898042 YBL034C STU1
SGTC_380 3970-0968 6 µM 0.272073753140175 0.374695886217637 no 1234 0.392782655250163 1812 2891601
SGTC_1679 SEC14.276 6.7 µM 0.272054765629721 0.374704181389203 no 1235 0.392789954951282 1969 1005053 YMR079W SEC14
SGTC_1510 1123-0200 71.5 µM 0.271743843243225 0.374840023900154 no 1236 0.392909493651138 1924 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2696 st077691 74.316 µM 0.271683988164256 0.374866176467469 no 1237 0.392932506979238 1837 757133
SGTC_1344 1488-0097 29.1 µM 0.270817315358208 0.375244917518688 no 1238 0.393265770822704 1862 747966
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.270675071888139 0.375307090243587 no 1239 0.393320475536584 1703 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1349 flufenamic acid 69 µM 0.269026314763095 0.376027975994695 no 1240 0.393954716333973 1810 3371 A non-steroidal anti-inflammatory.
SGTC_2742 clothiapine 36.27 µM 0.268600973461708 0.376214018219554 no 1241 0.39411838155085 1944 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2561 acetosyringone 100 µM 0.267959784898774 0.376494525347801 no 1242 0.394365137022657 1923 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_185 k048-0037 25.491 µM 0.267285968924073 0.376789376610302 no 1243 0.394624494540123 1962 6827589
SGTC_1579 chlormadinone acetate 49.4 µM 0.267059838496557 0.376888343843073 no 1244 0.394711544545701 1959 45114258 A steroidal progestin.
SGTC_2436 5633522 8.09 µM 0.266018599386909 0.377344152192461 no 1245 0.39511244236564 1967 5724242
SGTC_693 4161-2696 114 µM 0.265784494541755 0.377446656478113 no 1246 0.395202592705498 1916 805759
SGTC_2738 aclarubicin 5.55 µM 0.265398949677299 0.377615488547753 no 1247 0.395351072598105 1911 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2363 9053361 176 µM 0.264620245733829 0.377956558278815 no 1248 0.395651011060003 1939 6469797 YMR079W SEC14
SGTC_1489 4065-0444 182 µM 0.263294665679134 0.3785373766512 no 1249 0.396161735428925 1967 2877968
SGTC_1157 4092-0394 27.6 µM 0.262626644274689 0.378830182132045 no 1250 0.396419180791151 1925 3659885
SGTC_1199 1638-0010 4.46 µM 0.262585333001843 0.37884829187188 no 1251 0.396435103016074 1793 3111136
SGTC_2994 9053520 71.4286 µM 0.26155844902113 0.379298535298484 no 1252 0.396830940931217 1945 4647384
SGTC_282 k297-0036 65.7 µM 0.261422951199863 0.379357957372263 no 1253 0.396883179878538 1895 5061378
SGTC_346 4513-0042 7.16 µM 0.260866327446691 0.379602092571778 no 1254 0.397097796379103 1805 2827372
SGTC_572 0960-0087 17.7 µM 0.259716434568978 0.380106587556637 no 1255 0.397541257299327 1770 6796365
SGTC_710 3448-4187 58 µM 0.259623788522355 0.380147243250912 no 1256 0.397576992401679 1843 3946412
SGTC_508 roscovitine 141 µM 0.258941018496134 0.380446902781565 no 1257 0.397840374509159 1885 160355 A CDKinase inhibitor.
SGTC_1767 st044992 70.3 µM 0.258829085071818 0.38049603586243 no 1258 0.397883557858978 1801 9600693
SGTC_2381 9035592 200 µM 0.258282057722861 0.380736180768338 no 1259 0.398094616235813 1774 4749657
SGTC_2083 5306046 65.942 µM 0.257843770095658 0.380928622122531 no 1260 0.398263741323256 1825 539837
SGTC_1571 st070080 73.4 µM 0.256672101586751 0.381443217557392 no 1261 0.398715954943119 1921 4315245
SGTC_3094 9117742 49.47 µM 0.256492136200298 0.381522276740682 no 1262 0.398785425902081 1869 17149698
SGTC_2216 7189485 200 µM 0.255778237299757 0.381835942740348 no 1263 0.399061039585217 1938 731273
SGTC_779 1360-0071 233 µM 0.254059554948181 0.382591398684163 no 1264 0.39972477442462 2000 7566
SGTC_2975 9084847 53.72 µM 0.253929288890951 0.382648676080042 no 1265 0.399775093479804 1814 27211724
SGTC_54 0159-0055 9 µM 0.253721611267535 0.382739996299146 no 1266 0.399855318446794 1988 3319099
SGTC_2358 9037157 4 µM 0.25312608707133 0.383001896949505 no 1267 0.400085390296236 1882 2388925
SGTC_1265 0819-1001 68.8 µM 0.252988852738301 0.383062257687874 no 1268 0.400138413644469 1876 3106768
SGTC_2073 5212005 126 µM 0.252890314537792 0.383105600186591 no 1269 0.40017648706997 2011 691789
SGTC_744 1594-0068 283 µM 0.252244406153135 0.383389742291053 no 1270 0.400426078172532 1832 668392
SGTC_107 0358-0022 2.6945 µM 0.251144460262248 0.383873764727088 no 1271 0.400851211419982 1952 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2212 7123476 200 µM 0.249427191314775 0.384629797325912 no 1272 0.401515177020024 1933 1085715
SGTC_3265 9137266 49.47 µM 0.249327481096862 0.384673708548101 no 1273 0.401553737776851 2034 17224265
SGTC_2920 7982904 15.77 µM 0.247783963357797 0.385353644238074 no 1274 0.402150781731621 1843 6456808
SGTC_1004 4084-0029 199 µM 0.247688180562052 0.385395849199149 no 1275 0.402187838757624 1984 716894 YLR208W SEC13
SGTC_1113 artemisinin 1.17947 µM 0.247418208444392 0.385514814845189 no 1276 0.40229229192978 1990 2240 An anti-malaria and mitochondrial poison.
SGTC_96 0929-0093 37.281 µM 0.247224791309996 0.385600052471994 no 1277 0.402367129997175 1827 6991579
SGTC_1983 st071813 46.9 µM 0.247077737020586 0.385664862003179 no 1278 0.402424031481456 1871 11838595
SGTC_92 0063-0024 660.874 µM 0.247059141858202 0.385673057460779 no 1279 0.402431226878484 1993 3594437
SGTC_131 0141-0277 33.849 µM 0.246644617199664 0.385855764417863 no 1280 0.402591635749181 1959 1547771
SGTC_1410 3909-8106 77.9 µM 0.24588586813856 0.386190258183428 no 1281 0.402885291822622 1963 1039210
SGTC_2183 6420625 130.508 µM 0.245421183096821 0.386395155913039 no 1282 0.403065164360565 1887 2897619
SGTC_1796 st049173 110.4 µM 0.245404034636485 0.38640271794346 no 1283 0.403071802662418 1980 94134
SGTC_2263 7948595 193.29 µM 0.245366937217333 0.3864190770998 no 1284 0.403086163456366 1820 2971371
SGTC_1762 st045503 25.4615 µM 0.243147313021265 0.387398249600992 no 1285 0.403945640127137 1839 4645554
SGTC_2943 9068529 45.32 µM 0.240674694271471 0.388489872778289 no 1286 0.404903626784893 1948 3270634
SGTC_62 0180-0423 3.232 µM 0.240297498345352 0.388656476672282 no 1287 0.40504981711891 1932 30102 YGL099W LSG1
SGTC_2753 fluvastatin 17.09 µM 0.239755048501888 0.388896107570153 no 1288 0.405260078362774 1902 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_465 cgp-37157 41 µM 0.237847790686302 0.389738986712029 no 1289 0.405999575237293 2006 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2188 6126565 140.678 µM 0.237426616686138 0.389925187249454 no 1290 0.406162921423415 1968 874518
SGTC_155 k072-0202 43.6 µM 0.23720612454073 0.390022676648621 no 1291 0.406248442598537 1995 5857737
SGTC_262 fenpropimorph 62.5 µM 0.236099693150316 0.390511983590057 no 1292 0.406677656015483 1863 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1851 st056236 18.9 µM 0.235206426321742 0.390907147469695 no 1293 0.407024259208471 2000 5393171
SGTC_777 1315-0167 517 µM 0.235201945244117 0.390909130095686 no 1294 0.407025998128976 1830 4221767
SGTC_880 0833-0487 87.2 µM 0.235032893343368 0.390983928168795 no 1295 0.407091601503664 1839 76075
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.233803254911856 0.391528110588468 no 1296 0.407568861275431 2037 551469
SGTC_1499 4480-0877 67.3 µM 0.233706447253059 0.391570962315664 no 1297 0.407606441084457 1981 2861909
SGTC_591 4299-0174 154 µM 0.232390055785798 0.392153790897732 no 1298 0.408117535934713 1926 5509088
SGTC_1145 3546-0597 10.2 µM 0.231892459461886 0.392374163364258 no 1299 0.408310770695925 1897 875334
SGTC_2899 9053889 58.44 µM 0.229137914690401 0.393594702181473 no 1300 0.409380862810818 2041 6470052
SGTC_492 tmb-8 126 µM 0.228192940456112 0.39401366191271 no 1301 0.40974812468766 2014 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2348 9022543 33.42 µM 0.226968688131347 0.394556623552156 no 1302 0.410224045025893 1918 3162678 YDL140C RPO21
SGTC_753 1322-0200 289 µM 0.226937228235568 0.394570578868186 no 1303 0.410236276607081 1927 5403907
SGTC_3069 9117009 49.47 µM 0.226711868291613 0.394670550390246 no 1304 0.410323898917601 2029 41904981
SGTC_1074 carmofur 3.8 µM 0.224464538696552 0.395667862726917 no 1305 0.411197928473575 1942 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2705 st078069 42.8 µM 0.224205260853223 0.395782968274046 no 1306 0.411298795051348 1896 1530061
SGTC_1525 8-methoxypsoralen 92.5 µM 0.223423601977319 0.396130038134122 no 1307 0.411602918414234 2047 4114 Related to psoralen; DNA damaging agent.
SGTC_1063 disulfiram 1.84 µM 0.22310469749282 0.396271660826695 no 1308 0.411727011212498 1926 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1226 3909-7979 35.4 µM 0.222876079231723 0.396373196622738 no 1309 0.411815977075872 2000 6615510
SGTC_60 0986-0278 202 µM 0.22259684182899 0.396497223337375 no 1310 0.411924647321147 1736 3110598
SGTC_1262 0737-0114 49.6 µM 0.222182104365598 0.396681453392039 no 1311 0.412086062310575 2039 765919
SGTC_1561 5-methoxyflavone 52.9 µM 0.221635984517362 0.396924079843604 no 1312 0.412298633745643 2016 94525
SGTC_2140 5586273 200 µM 0.221181207777922 0.397126155449146 no 1313 0.412475670469656 1976 854421
SGTC_3083 9117465 49.47 µM 0.220766466674645 0.397310465692611 no 1314 0.412637137539446 1845 16420915
SGTC_2667 digitoxin 100 µM 0.220644712107273 0.397364577572133 no 1315 0.412684541854678 2042 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_193 1273-0060 1.558 µM 0.22046106454469 0.397446200544818 no 1316 0.412756046196832 2008 2847393 YHR072W ERG7
SGTC_427 1354-0053 47.3 µM 0.219635486935896 0.397813187592584 no 1317 0.413077525797499 2000 6813657
SGTC_2861 9024595 19.48 µM 0.219329744689478 0.397949119579746 no 1318 0.413196596513508 2046 16482810
SGTC_2983 9022671 12.99 µM 0.21864224112589 0.39825482660658 no 1319 0.413464372571965 2070 6405161
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.218433653616102 0.398347590000843 no 1320 0.413545623375616 1905 390807
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.218001617266062 0.398539744212155 no 1321 0.413713925667591 1993 688801
SGTC_872 0588-0139 234 µM 0.217955098787386 0.398560435424207 no 1322 0.413732048159414 1894 2047100
SGTC_1625 st003711 30.1 µM 0.216937576713724 0.399013095946777 no 1323 0.414128496435722 1986 24207034 YER133W GLC7
SGTC_2876 9059903 25.97 µM 0.213453671800531 0.400563990544975 no 1324 0.415486560457683 2029 6916095
SGTC_2989 9073649 71.4286 µM 0.212650588837889 0.400921714241123 no 1325 0.415799754787682 2080 21367202
SGTC_3218 9131285 49.47 µM 0.212404583525199 0.401031311002849 no 1326 0.415895705112616 2025 17156417
SGTC_1348 1493-0373 93.8 µM 0.209457860551268 0.402344695873115 no 1327 0.417045414067319 1973 3010129
SGTC_2104 5389443 200 µM 0.20875338603747 0.402658851395144 no 1328 0.417320381048098 2006 2244536
SGTC_1547 harmine 94.2 µM 0.208306679981035 0.402858089444975 no 1329 0.417494758089234 1965 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_3145 9085516 49.47 µM 0.206805192458749 0.40352796153335 no 1330 0.418081000410018 1838 25236195
SGTC_1208 2323-2347 50.3 µM 0.206485297903297 0.403670715610735 no 1331 0.418205923936422 2082 5412760
SGTC_718 1130-0073 349 µM 0.206029726884391 0.403874037938443 no 1332 0.418383845357201 1996 6740020
SGTC_3282 9108498 15.4605 µM 0.205157802991058 0.404263251840536 no 1333 0.41872441825059 1922 16459645
SGTC_2934 9036370 36.88 µM 0.205066673986112 0.404303935954717 no 1334 0.418760016700344 2016 6462800
SGTC_1908 st060353 56.5 µM 0.204808290267522 0.404419295772225 no 1335 0.418860954808625 2081 4227716
SGTC_2225 6654152 15.4 µM 0.204299356472957 0.404646542239796 no 1336 0.419059786413851 2021 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1917 st066507 28.5 µM 0.203287561268258 0.405098419239099 no 1337 0.419455138609207 1900 3156428
SGTC_1916 st067606 49.2 µM 0.203072133569187 0.405194647583094 no 1338 0.419539326053278 2010 19590279
SGTC_933 2914-0560 114 µM 0.202246054782246 0.405563697753017 no 1339 0.419862185228454 2101 463887
SGTC_2437 5741531 144.16 µM 0.201564401320477 0.405868289244934 no 1340 0.420128638795459 2065 2262990
SGTC_1060 3448-7350 82 µM 0.201012119901148 0.406115113661064 no 1341 0.420344548590878 2049 570178
SGTC_2171 5739187 198.077 µM 0.199728760296089 0.406688813916649 no 1342 0.420846359741118 1919 2262761
SGTC_2069 5228469 200 µM 0.199550746386215 0.406768407324598 no 1343 0.420915975791004 1945 2835210
SGTC_2199 6590217 200 µM 0.19916262384731 0.406941957648605 no 1344 0.421067767770641 2023 703109
SGTC_1180 1193-0155 285 µM 0.196453976266922 0.408153645690304 no 1345 0.422127426151288 1945 2921347
SGTC_2786 7743617 45.45 µM 0.195154544215638 0.408735247058559 no 1346 0.422635981628534 1878 583674
SGTC_174 3553-0389 74.3 µM 0.194687085891408 0.408944521855778 no 1347 0.422818961214531 2000 738071
SGTC_1944 st076371 56.9 µM 0.194364464688225 0.409088970168819 no 1348 0.422945256185882 1885 24208455
SGTC_975 1335-0046 28.5 µM 0.194317987831489 0.409109780431369 no 1349 0.422963450910478 1874 16486740
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.19418557650412 0.409169069719662 no 1350 0.423015288097229 2003 2333 A French combination drug.
SGTC_2465 5809242 33.21 µM 0.193454791615123 0.409496327680978 no 1351 0.423301404136557 1997 2731748
SGTC_2977 9011197 71.43 µM 0.192730216507349 0.409820867070347 no 1352 0.423585128868096 2034 2704722
SGTC_1885 st057546 99.9 µM 0.192277804955186 0.410023534927451 no 1353 0.423762301546413 2046 702008
SGTC_1296 1068-0102 11.9 µM 0.19193762980953 0.41017593981547 no 1354 0.423895530538651 2053 767053
SGTC_1587 estradiol valerate 56.1 µM 0.191695476777871 0.410284437214027 no 1355 0.423990374645 2072 13791 A steroid.
SGTC_17 0960-0276 49.807 µM 0.191446408060931 0.410396040370667 no 1356 0.424087932011697 2035 6821114
SGTC_1399 3562-5772 25 µM 0.190840307875646 0.410667653124694 no 1357 0.424325353942032 1983 23847490
SGTC_1931 st074438 57.1 µM 0.188870810444985 0.41155054267817 no 1358 0.425097035844883 2086 2787313
SGTC_1127 asiatic acid 681.4 nM 0.188854218250976 0.411557982563701 no 1359 0.42510353816651 1864 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2892 9047358 58.44 µM 0.188840762322357 0.411564016181439 no 1360 0.425108811430786 1958 6466771
SGTC_1615 st002656 86.5 µM 0.188194822865665 0.411853679014942 no 1361 0.425361965367716 2079 1584458
SGTC_2451 5856223 45.7 µM 0.187807782618729 0.412027265017196 no 1362 0.42551366734201 1931 2179896
SGTC_912 3474-0017 2.18 µM 0.187150284326597 0.412322189814985 no 1363 0.425771401696816 2037 3360550
SGTC_2107 5363541 170.161 µM 0.186245925216409 0.412727926375413 no 1364 0.426125955416167 2071 244052
SGTC_87 0100-0052 35.5 µM 0.184862750441066 0.413348661645197 no 1365 0.426668344104429 1995 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_123 0083-0120 66.675 µM 0.18482710682777 0.41336466050382 no 1366 0.42668232298449 1875 16001701
SGTC_3052 9092717 49.47 µM 0.184495537370929 0.413513494416793 no 1367 0.426812363865589 1961 25237534
SGTC_1496 4469-0713 57.4 µM 0.182983169473645 0.414192518933237 no 1368 0.427405612234064 2071 746691
SGTC_769 0302-0231 76 µM 0.182975597311231 0.414195919337818 no 1369 0.42740858293943 2059 571869 YER009W NTF2
SGTC_1509 1326-1131 80 µM 0.182734553607543 0.414304167353527 no 1370 0.427503151183686 2085 768313
SGTC_1240 0356-0016 42.1 µM 0.182241377584116 0.414525663341815 no 1371 0.427696651023379 1993 4305613
SGTC_2214 7179297 48.276 µM 0.181680560472448 0.414777571428203 no 1372 0.42791671128058 2032 769744
SGTC_602 3130-1533 38.1 µM 0.180881490090013 0.415136558751197 no 1373 0.428230298980665 2074 720941
SGTC_1614 st002383 48.6 µM 0.180062795678834 0.41550443578609 no 1374 0.428551634957477 2130 1947235
SGTC_2675 theaflavin digallate 100 µM 0.179685300534165 0.415674086680082 no 1375 0.428699817043906 2029 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1065 prochlorperazine maleate 2.48 µM 0.178593482008056 0.416164851528375 no 1376 0.42912845640514 2052 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1195 1502-0147 41.1 µM 0.177947674891259 0.416455198932904 no 1377 0.429382034572699 1988 817940
SGTC_150 3970-0969 77.2 µM 0.17538645450697 0.417607141421201 no 1378 0.430387991679745 1992 6615640
SGTC_2433 5607874 27.82 µM 0.175373846142874 0.417612813956315 no 1379 0.43039294492406 1997 2252428
SGTC_1109 tnp00067 928.257 nM 0.17534525259964 0.417625678327753 no 1380 0.430404178048046 1959 676295
SGTC_633 0437-0093 97.7 µM 0.174705125596508 0.417913697572369 no 1381 0.43065567003824 2021 2831118
SGTC_542 3381-0244 89.3 µM 0.1742317781719 0.41812670421066 no 1382 0.430841656050722 2099 1112843
SGTC_3003 9075612 71.4286 µM 0.174225007751446 0.418129751078477 no 1383 0.430844316371984 2003 6501993
SGTC_1707 st032323 6.317 µM 0.173566140608203 0.418426282151771 no 1384 0.431103221974055 2034 3132057 YMR211W DML1
SGTC_345 1362-0200 395 µM 0.173480087084652 0.418465015000793 no 1385 0.431137039385472 1935 1419823
SGTC_2236 dapsone 200 µM 0.173340768157166 0.418527724381878 no 1386 0.431191790166013 2111 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_3173 9105693 49.47 µM 0.17221871814765 0.419032850010685 no 1387 0.431632791390886 2054 17096658
SGTC_2262 9014885 67.46 µM 0.171194426466568 0.41949408327642 no 1388 0.432035444919116 2092 6457424
SGTC_2907 7721985 69.9 µM 0.1704328959954 0.41983706826202 no 1389 0.432334851656926 1950 3267881
SGTC_2729 fluphenazine 10.66 µM 0.1701829453443 0.419949656585608 no 1390 0.432433131855989 2069 3372 An atypical antipsychotic.
SGTC_1037 k284-1091 78.7 µM 0.169361172689199 0.420319863808626 no 1391 0.432756280994229 2083 3334711
SGTC_1703 st026983 48.3 µM 0.168250683874508 0.420820249132656 no 1392 0.433193034627182 2122 1104023
SGTC_3327 9140648 26.9345 µM 0.167198354861103 0.421294545792147 no 1393 0.433606989414937 2106 8029710
SGTC_3310 9130229 44.1445 µM 0.166066713699397 0.421804716794587 no 1394 0.434052224501786 2083 7761258
SGTC_833 3852-0053 558 µM 0.165143206784506 0.422221153194703 no 1395 0.43441563288267 2048 3123681
SGTC_1677 st019204 53.9 µM 0.164815063247563 0.422369143721089 no 1396 0.434544773714725 1930 3945625
SGTC_303 1348-1668 34.2 µM 0.163406778111272 0.423004395036329 no 1397 0.435099083226928 2037 5380509
SGTC_3285 9112818 20.8695 µM 0.163354694581078 0.423027892801151 no 1398 0.435119586071044 2079 17017947 YPR165W RHO1
SGTC_3235 9132602 49.47 µM 0.16190369189233 0.423682630254196 no 1399 0.435690847734859 2046 4912240
SGTC_1698 5-fluorocytosine 1.055 µM 0.160269794088165 0.424420147860192 no 1400 0.436334276047895 2128 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2867 9039098 71.43 µM 0.160213276965735 0.42444566361522 no 1401 0.436356535493406 2029 6463460
SGTC_809 3998-0021 90 µM 0.158465504773222 0.425234885181026 no 1402 0.437045000192789 2144 715485
SGTC_3185 9108267 49.47 µM 0.15711338306911 0.425845653156715 no 1403 0.437577745205003 1990 4910486
SGTC_1861 st057647 17.4 µM 0.155477687722265 0.426584752126399 no 1404 0.438222371326643 2114 688668
SGTC_2339 9000433 200 µM 0.153170996723246 0.427627482281876 no 1405 0.439131714505722 1968 2988954
SGTC_69 0096-0274 206.684 µM 0.15312215883378 0.427649564740889 no 1406 0.43915097085742 2086 6741392
SGTC_2483 5729050 27.16 µM 0.152849569543927 0.427772822422555 no 1407 0.439258453068555 2130 2865180
SGTC_821 1114-0266 29.2 µM 0.151311925711929 0.428468236063262 no 1408 0.43986483111964 2034 3123235
SGTC_1420 4'-methoxyflavone 42 µM 0.151252921486681 0.428494925709689 no 1409 0.439888102570784 2139 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_742 0kpi-0133 140 µM 0.150943343266275 0.428634963974261 no 1410 0.44001020459164 2128 2728852
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.15071786824146 0.428736963663593 no 1411 0.44009913871663 2143 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2245 6637752 200 µM 0.150575943133992 0.428801169743005 no 1412 0.440155119793867 2136 681890
SGTC_2781 5567276 71.43 µM 0.150221789470908 0.428961394979729 no 1413 0.440294817723722 2085 2853274
SGTC_1766 st045414 44.774 µM 0.149998349079413 0.429062489298377 no 1414 0.440382958883887 2112 253960
SGTC_3104 9120930 49.47 µM 0.149695416339158 0.429199556902577 no 1415 0.4405024623314 2048 17014836
SGTC_863 0466-0191 129 µM 0.149499827314556 0.429288059364414 no 1416 0.440579622809605 2147 765160 YPR165W RHO1
SGTC_370 0180-0345 38.7 µM 0.149096930098758 0.42947037831453 no 1417 0.440738574121211 2022 3989527
SGTC_3054 9094397 49.47 µM 0.148962385631995 0.429531265696756 no 1418 0.440791656833107 2054 2598354
SGTC_3233 9132340 49.47 µM 0.148502208230093 0.429739529193705 no 1419 0.440973221681541 2006 17682950
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.148196668435408 0.429877818814294 no 1420 0.441093780495442 2046 115019
SGTC_527 4476-4215 268 µM 0.147832414251774 0.430042694252048 no 1421 0.441237513758182 2017 4418754
SGTC_2602 kawain 100 µM 0.147820904760929 0.430047904088763 no 1422 0.441242055484073 2179 5369129
SGTC_1996 st072960 66.8 µM 0.147764454038185 0.43007345700692 no 1423 0.441264331447466 2163 1719405
SGTC_672 1441-0018 53.7 µM 0.147662426349088 0.430119641484344 no 1424 0.44130459296345 2031 251141
SGTC_2293 7624732 200 µM 0.147436417147376 0.430221951595037 no 1425 0.441393781432704 2097 894453
SGTC_2097 5376186 200 µM 0.146277398960773 0.430746690777636 no 1426 0.441851203475144 2129 742755
SGTC_3123 9126162 49.47 µM 0.145996400873987 0.430873929587722 no 1427 0.441962114835566 2071 25239884
SGTC_2257 7960413 200 µM 0.144594688605832 0.431508746169149 no 1428 0.442515445520256 2074 2974689 YIL048W NEO1
SGTC_1478 0453-0656 35.7 µM 0.144111911708562 0.431727430363567 no 1429 0.442706049363736 2123 5258496
SGTC_1896 st058441 89 µM 0.142191100400987 0.432597709817222 no 1430 0.44346453060807 2001 688759
SGTC_2032 5185112 25.99 µM 0.14160753024826 0.432862178230022 no 1431 0.443695009300385 2131 5718189
SGTC_2038 4100038 30.985 µM 0.141342288979941 0.432982392984988 no 1432 0.443799771576586 2078 3596803
SGTC_2645 abamectin 100 µM 0.140904451875185 0.433180846560271 no 1433 0.443972712575636 2122 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_31 0508-1974 57.237 µM 0.140668601397226 0.433287754880888 no 1434 0.444065875429425 2135 6810525
SGTC_2525 harmine 47.85 µM 0.140125457367375 0.433533974403721 no 1435 0.444280433478095 2093 5280953 A monoamine oxidase inhibitor
SGTC_2477 5967686 25.23 µM 0.139174000101997 0.433965353709276 no 1436 0.444656326722745 2058 776118
SGTC_1748 st037455 53.6035 µM 0.138186657643852 0.434413086089519 no 1437 0.445046449794577 2064 580690
SGTC_199 4063-0024 41.6 µM 0.137930097617555 0.434529442730664 no 1438 0.445147831642865 2145 306215
SGTC_2321 7390090 138.78 µM 0.137345682825847 0.434794511188095 no 1439 0.445378781437789 1993 649046
SGTC_1024 4507-0395 26 µM 0.136412015825276 0.435218048016278 no 1440 0.445747787608124 2044 4201836
SGTC_2715 st079500 56.4 µM 0.13551024104804 0.435627188236241 no 1441 0.446104233878962 2077 28246688
SGTC_1864 st057645 30.4 µM 0.134961423505206 0.435876223560522 no 1442 0.446321187397652 2193 688666
SGTC_2375 9072683 200 µM 0.134827960988642 0.435936788301968 no 1443 0.446373949007534 2190 16798029
SGTC_405 ebelactone b 50 µM 0.134808202404681 0.43594575479386 no 1444 0.446381760230467 2036 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1887 st057648 70.8 µM 0.134743182839516 0.435975261057922 no 1445 0.446407464765843 2167 688672
SGTC_153 4077-0274 519.67 µM 0.134346398751529 0.436155331745737 no 1446 0.446564332435852 2180 3121976
SGTC_3269 9137823 49.47 µM 0.134043992722013 0.436292580164464 no 1447 0.446683893575664 2006 17682936
SGTC_507 nimesulide 162 µM 0.133573235724171 0.43650625073251 no 1448 0.446870024648432 2160 4495 A COX2 inhibitor.
SGTC_2172 5754775 163.918 µM 0.132543548279891 0.436973677167531 no 1449 0.447277190149198 2051 2263357
SGTC_1726 st035556 14.5795 µM 0.131467411332907 0.437462283382457 no 1450 0.447702782388358 2157 5919439
SGTC_1256 0570-0116 285 µM 0.130960471821835 0.437692485878789 no 1451 0.447903288473468 2057 410638
SGTC_2793 7325131 81.82 µM 0.130738312316227 0.437793375715606 no 1452 0.447991161799514 2097 4176441
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.126177910021369 0.439865286588863 no 1453 0.44979554842358 2196 756377
SGTC_477 mead ethanolamide 10 µM 0.125108550673233 0.440351365331193 no 1454 0.450218807014077 2186 16061185
SGTC_2077 5212015 200 µM 0.124618775369113 0.440574023422598 no 1455 0.450412681837884 2194 780900
SGTC_689 0833-0039 98 µM 0.123315114989628 0.441166775421027 no 1456 0.450928786076915 2161 5374726
SGTC_371 0195-0006 7.36 µM 0.121859099038071 0.441828956652777 no 1457 0.451505304193778 2115 3928593
SGTC_1437 4092-1038 11.6 µM 0.120578345431561 0.442411564841763 no 1458 0.452012510759916 2145 3977136
SGTC_1087 pterostilbene 9.05 µM 0.120179020269099 0.442593241326269 no 1459 0.45217066835531 2178 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2491 paeonol 100 µM 0.119580729430781 0.442865461572277 no 1460 0.45240764292804 2079 11092 Increases levels of cortical cytochrome oxidase.
SGTC_675 1309-0189 238 µM 0.119235413505194 0.443022591399917 no 1461 0.452544425423862 2072 4246530
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.11865275553051 0.443287739780546 no 1462 0.452775233829853 2234 16623 A steroid.
SGTC_987 1497-1013 404 µM 0.118033810338173 0.443569429089235 no 1463 0.453020434174895 2186 1676435
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.117798545403662 0.443676508442865 no 1464 0.45311364106173 2197 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_613 3914-0030 117 µM 0.117650588027619 0.443743852417904 no 1465 0.453172259902612 2170 1145395
SGTC_2745 rifampicin 24.3 µM 0.117551523262016 0.443788943441066 no 1466 0.453211508680082 2211 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2995 9067767 71.4286 µM 0.117228381903063 0.443936031815352 no 1467 0.453339538234778 2103 11673567
SGTC_2402 5553605 200 µM 0.116575978009153 0.444233018333718 no 1468 0.453598037339034 2151 6758546
SGTC_2877 9040724 71.43 µM 0.116201635560556 0.444403440204535 no 1469 0.453746370272877 2214 6463895
SGTC_3318 9139014 38.6185 µM 0.115291469373126 0.444817842187349 no 1470 0.454107049864693 2063 16643984
SGTC_853 0419-0306 21 µM 0.114858776875909 0.445014869840199 no 1471 0.454278530033259 2045 762713
SGTC_2894 9048625 32.47 µM 0.114815835104324 0.445034424229232 no 1472 0.454295548732793 2205 4092861
SGTC_1832 st054113 55 µM 0.114717967324122 0.445078990767481 no 1473 0.454334336042809 2220 1251267
SGTC_746 1095-0025 46.6 µM 0.114315466366465 0.445262286924239 no 1474 0.454493861241783 2190 6749286
SGTC_322 k048-0136 19.3 µM 0.114242135634964 0.445295682494395 no 1475 0.45452292556518 2145 6823282
SGTC_2553 4-methylesculetin 85.09 µM 0.113752889280323 0.445518500245385 no 1476 0.454716842499907 2104 5319502
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.113661405952923 0.445560166462283 no 1477 0.45475310389032 2180 6728940
SGTC_2300 7976697 71.57 µM 0.113259295251617 0.445743315500495 no 1478 0.454912493608603 2088 2236109
SGTC_1930 st074634 34.3 µM 0.113142745938716 0.445796402288508 no 1479 0.454958693095913 2201 684253 YOR116C RPO31
SGTC_1384 3089-0840 101 µM 0.112981442721102 0.445869875536257 no 1480 0.455022633782405 2193 1069836
SGTC_2699 st077704 54.6 µM 0.112822599859226 0.445942229914151 no 1481 0.45508560032126 2119 645852
SGTC_169 k015-0017 16.025 µM 0.111640496316167 0.446480745289694 no 1482 0.45555423064865 2180 1840002
SGTC_1480 1070-0044 41.2 µM 0.109366950200627 0.447516751487534 no 1483 0.456455723195061 2210 3124987
SGTC_1843 st055809 45.5 µM 0.108733167782844 0.447805616683009 no 1484 0.456707066863221 2116 16413835
SGTC_428 3448-4153 16.5 µM 0.108620093372454 0.447857156624613 no 1485 0.456751911422069 2019 3834874
SGTC_160 3453-0671 289.699 µM 0.108586376952251 0.447872524925829 no 1486 0.456765283236626 2183 5322268
SGTC_127 0180-0333 59.125 µM 0.108221109413357 0.448039022747227 no 1487 0.456910150202404 2224 771601
SGTC_1058 3448-5425 97.3 µM 0.106682074499088 0.448740652470295 no 1488 0.45752060195851 2203 7279705
SGTC_2143 5623677 140.463 µM 0.106331544260386 0.448900477992953 no 1489 0.457659652376583 2210 5375313
SGTC_1026 k007-1105 30.6 µM 0.106310449973939 0.448910096273489 no 1490 0.457668020348982 2212 7066794
SGTC_1951 sophoraflavanone G 9.2 µM 0.106174661916896 0.448972011749279 no 1491 0.457721887076751 2052 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1504 k297-0033 30 µM 0.105842470395098 0.449123486831167 no 1492 0.457853669760371 2096 4388117
SGTC_3237 9133362 49.47 µM 0.10574767371396 0.449166714265314 no 1493 0.457891277112527 2223 43845137
SGTC_1107 amlodipine 47 µM 0.104461381735781 0.449753324837235 no 1494 0.458401606737519 2179 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.104191542545357 0.449876398372899 no 1495 0.458508672757032 2107 75037 A free radical scavenger.
SGTC_2252 omeprazole 400 µM 0.103699924373374 0.450100637589466 no 1496 0.458703743336891 2170 4594 A proton pump inhibitor.
SGTC_1661 st013063 9.66 µM 0.103613708656478 0.450139964355967 no 1497 0.458737954143959 2208 721395
SGTC_1179 1021-1431 9.29 µM 0.101156867724601 0.451260841466507 no 1498 0.459712967796928 2157 2840958
SGTC_867 0518-0118 155 µM 0.100930928604931 0.451363940641591 no 1499 0.459802645495073 2245 6848158
SGTC_1967 st070177 51.4 µM 0.100254307280297 0.451672711996617 no 1500 0.460071216084882 2194 5729214
SGTC_2286 7945697 125 µM 0.100175403484132 0.451708721092997 no 1501 0.460102536474102 2129 1245733
SGTC_2298 7976326 193.81 µM 0.0997561044529584 0.451900082033132 no 1502 0.460268978861374 2186 2235818
SGTC_2264 7948757 110.76 µM 0.0995862441110787 0.451977606584897 no 1503 0.460336407570266 2218 2971411
SGTC_580 1123-0028 41 µM 0.0989796770326629 0.452254459765669 no 1504 0.460577203117078 2219 1677248 YPR107C YTH1
SGTC_2919 7978188 46.38 µM 0.0988949121659125 0.452293150534063 no 1505 0.460610854303801 2225 2980291
SGTC_1780 st038448 24.544 µM 0.0978097997361611 0.452788488012949 no 1506 0.461041662817554 2180 728868 YDL195W SEC31
SGTC_1662 st014054 52 µM 0.0973744821789967 0.452987224615285 no 1507 0.461214504341344 2235 2838777
SGTC_782 0083-0095 30.5 µM 0.0973062537692349 0.453018374168927 no 1508 0.461241594890746 2266 3591729 An indicator and reagent.
SGTC_1801 st050089 28.441 µM 0.0952505549136356 0.453957034372516 no 1509 0.462057907737086 2234 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1055 3448-0672 86 µM 0.0938273080457662 0.454607059369939 no 1510 0.462623169344245 2165 748378
SGTC_1782 st039423 80.636 µM 0.093791168584444 0.454623566566923 no 1511 0.462637523604211 2053 2068169
SGTC_751 0833-0568 350 µM 0.09372843681705 0.45465222035222 no 1512 0.462662440197849 2160 6954252
SGTC_1836 st055642 81 µM 0.0935725647934829 0.454723418530585 no 1513 0.462724352045824 2169 8571
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.0931767538323786 0.454904220940341 no 1514 0.462881570894158 2259 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2841 9004761 38.96 µM 0.0928827767702216 0.455038512712057 no 1515 0.462998344368227 2079 2991039
SGTC_1503 4585-0012 61.3 µM 0.0920498804890139 0.455419016225433 no 1516 0.463329204442357 2200 2922052
SGTC_1312 1218-2183 165 µM 0.0917148885386015 0.455572066778143 no 1517 0.463462283953639 2243 6744073
SGTC_13 0199-0087 65 µM 0.0916018559955753 0.455623710383102 no 1518 0.463507188390497 2252 4589825
SGTC_435 c-PAF 6.7 µM 0.0915938665318994 0.455627360729305 no 1519 0.463510362382225 2249 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2400 5203494 178.7 µM 0.0911490371383665 0.455830606967536 no 1520 0.463687084388315 2250 6777674
SGTC_1395 3486-0190 4.35 µM 0.0911474293692519 0.455831341591572 no 1521 0.463687723136514 2237 6748079
SGTC_517 1365-0151 113 µM 0.0904540887182622 0.456148157779172 no 1522 0.463963188113791 2148 768657
SGTC_1984 st072354 53.1 µM 0.0901787405297007 0.456273983567895 no 1523 0.464072589041869 2148 5762938
SGTC_1643 st009866 20.2 µM 0.0891047772009835 0.456764794095507 no 1524 0.46449932042099 2241 3156273 YOR207C RET1
SGTC_603 3794-0023 45.9 µM 0.087717897943158 0.457398707397317 no 1525 0.465050446977955 2250 3802260
SGTC_1946 st076057 65.1 µM 0.0868096386995232 0.457813912413678 no 1526 0.465411412987861 2257 953009
SGTC_1416 3966-0321 25.3 µM 0.0844532719363693 0.45889132426809 no 1527 0.466348026823365 2208 582530 YLR208W SEC13
SGTC_2687 chenodiol 100 µM 0.0825549208543271 0.459759535677513 no 1528 0.467102723403174 2195 5702181 A cholesterol synthesis inhibitor.
SGTC_1488 4013-0813 75.9 µM 0.0824827349514246 0.459792553734754 no 1529 0.467131423530646 2143 2910057
SGTC_1158 4092-0494 91.8 µM 0.0821779790444705 0.459931953091471 no 1530 0.467252592191966 2206 1148199
SGTC_2851 9015922 71.43 µM 0.0818237353079225 0.460093995020723 no 1531 0.467393440655938 2234 2996893
SGTC_1686 st019653 115.5 µM 0.0817859828005508 0.460111264564581 no 1532 0.467408451416927 2260 97252
SGTC_3232 9132874 49.47 µM 0.0812318524580735 0.460364755130998 no 1533 0.467628784306373 2183 3784940
SGTC_417 st075190 100 µM 0.080874397360837 0.460528283868135 no 1534 0.46777092059965 2265 222757
SGTC_944 3370-0224 231 µM 0.0787145846069383 0.461516497139582 no 1535 0.468629822318663 2205 4580514
SGTC_14 0354-0009 295 µM 0.0780790534411792 0.461807327287625 no 1536 0.468882584625941 2256 1713507
SGTC_2592 piperlongumine 83.33 µM 0.0773929955086165 0.462121302284649 no 1537 0.469155456422855 2176 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_315 k915-0449 187 µM 0.0758399578577842 0.462832138185682 no 1538 0.469773212938028 2187 20970215 YNL149C PGA2
SGTC_1027 k015-0025 8.67 µM 0.0747921402106604 0.463311798654928 no 1539 0.470190047753182 2285 3598955
SGTC_2075 5212009 200 µM 0.0741669849637933 0.463598002011313 no 1540 0.470438757828484 2268 780898
SGTC_362 0310-0100 9.03 µM 0.0740327239172693 0.463659470745538 no 1541 0.470492173388259 2207 790235
SGTC_3096 9117468 49.47 µM 0.0726235431434556 0.464304688031651 no 1542 0.471052845733437 2275 41316311
SGTC_1642 st009582 77.7 µM 0.0726098720913013 0.464310948016991 no 1543 0.471058285333224 2258 6739311
SGTC_53 0973-0023 39.979 µM 0.0723438847660159 0.464432745574865 no 1544 0.471164120586771 2301 674768
SGTC_2810 7959871 45.46 µM 0.0723291620935335 0.464439487292624 no 1545 0.471169978736641 2228 2974535
SGTC_2915 7971052 15.16 µM 0.0723211192511471 0.464443170227016 no 1546 0.471173178985435 2275 5741558
SGTC_3188 9110789 49.47 µM 0.0721436450994211 0.464524438994545 no 1547 0.47124379646369 2257 849217
SGTC_2824 7998404 51.95 µM 0.0719156529828119 0.464628843064154 no 1548 0.471334516512821 2233 837851
SGTC_2185 6113692 200 µM 0.0717821463933926 0.464689980656658 no 1549 0.471387640638507 2210 874150
SGTC_2676 harmalol 100 µM 0.0714976641411358 0.464820258353764 no 1550 0.471500841773802 2273 5459187 A monoamine oxidase inhibitor
SGTC_1641 st009299 47.1 µM 0.0710717680149251 0.465015303106874 no 1551 0.471670318597691 2293 4046054
SGTC_111 0083-0039 52.457 µM 0.0697507738656906 0.465620323077264 no 1552 0.472196014228381 2297 759313
SGTC_462 ag-879 158 µM 0.0692073092451694 0.465869254939949 no 1553 0.47241230256186 2280 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2366 9070441 60.58 µM 0.068296766034007 0.4662863556107 no 1554 0.4727746992255 2263 6837235
SGTC_3175 9106517 49.47 µM 0.0665066906145631 0.467106459001421 no 1555 0.473487215582527 2222 41468073
SGTC_286 k060-0067 22.9 µM 0.0662981437983998 0.467202011584044 no 1556 0.473570230504834 2248 5985051
SGTC_1562 morin hydrate 59.1 µM 0.0661697918998454 0.467260821167628 no 1557 0.473621323310403 2227 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2405 ticlatone 3.52 µM 0.0644568590564875 0.468045738138062 no 1558 0.474303228563601 2321 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_552 k242-0005 476 µM 0.0644011540850699 0.468071265921529 no 1559 0.474325405554705 2225 4088318
SGTC_80 0159-0065 512.242 µM 0.0637560169622187 0.468366920899946 no 1560 0.474582250173194 2288 1548079
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.0628792881933301 0.468768738185982 no 1561 0.474931313914497 2259 4174840
SGTC_627 1391-0720 175 µM 0.0619437543466827 0.469197541754965 no 1562 0.475303811723828 2237 997839
SGTC_2117 5521686 200 µM 0.0619006997333911 0.469217276775831 no 1563 0.475320955130893 2251 803312
SGTC_1015 4130-4525 82 µM 0.0615530469410292 0.46937663378096 no 1564 0.475459384554229 2185 1363237
SGTC_495 decylubiquinone 155 µM 0.0610912342285545 0.469588326965576 no 1565 0.475643275092543 2154 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_161 4065-0411 162.148 µM 0.0609384714084773 0.469658354754322 no 1566 0.475704105305107 2240 1906281 YLR208W SEC13
SGTC_2158 5657123 3.6195 µM 0.0601531586911069 0.470018363615243 no 1567 0.476016826032614 2318 2858827
SGTC_2167 5876490 200 µM 0.0598412816449109 0.470161343412034 no 1568 0.47614102323659 2259 686534
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.0591265663396494 0.4704890185856 no 1569 0.476425649386915 2294 66535 A nucleotide analog.
SGTC_311 1315-0136 58 µM 0.0590611308053228 0.470519019784629 no 1570 0.476451708847548 2282 6759207
SGTC_456 gingerol 170 µM 0.058309846211006 0.470863484312069 no 1571 0.476750912359511 2251 442793 A herb.
SGTC_502 l-744,832 89.3 µM 0.0582179625247639 0.470905614549745 no 1572 0.476787506481363 2316 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_429 1112-0049 25.5 µM 0.0569771790943548 0.471474566616989 no 1573 0.477281687023629 2165 2836170
SGTC_1472 k841-0093 193 µM 0.0567221388137396 0.471591520703483 no 1574 0.477383269091081 2288 X1472
SGTC_2523 spermine 47.74 µM 0.0565408093609266 0.471674674629761 no 1575 0.477455493167703 2301 1103 A DNA binding polyamine.
SGTC_3097 9117246 49.47 µM 0.0562805168318486 0.471794041542612 no 1576 0.477559169773308 2295 16423892
SGTC_8 0354-0001 70 µM 0.0554128725059656 0.472191950665831 no 1577 0.477904770409151 2289 4993152
SGTC_2175 5807670 165.306 µM 0.0549948729315228 0.472383658784133 no 1578 0.478071274210519 2302 241186
SGTC_2716 st080858 38.6235 µM 0.0535302315858541 0.473055440847246 no 1579 0.478654721925366 2317 5296050
SGTC_2479 5617353 43.85 µM 0.0531929568882076 0.473210148411505 no 1580 0.478789083630717 2302 2731746
SGTC_3351 9150312 21.596 µM 0.0530097953668546 0.47329416611159 no 1581 0.478862051557191 2315 4904905
SGTC_1098 clofazimine 15.1 µM 0.0528957436501931 0.473346483174873 no 1582 0.478907487862814 2296 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_566 0958-0068 16.5 µM 0.0522109498701688 0.473660616969211 no 1583 0.47918030405018 2292 6815365
SGTC_1365 1672-3266 55.4 µM 0.051728444659361 0.473881965265394 no 1584 0.479372536007276 2310 6415873
SGTC_1794 st048918 76.9 µM 0.0508696111494679 0.474275973319047 no 1585 0.47971471046787 2314 672303
SGTC_866 0495-0101 262 µM 0.0498971329740991 0.47472214862611 no 1586 0.480102181007391 2254 635694
SGTC_940 3232-1287 54.8 µM 0.0494434788235171 0.474930297111491 no 1587 0.480282939711154 2329 1585493 YIL048W NEO1
SGTC_2033 5192550 145 µM 0.0492436898543314 0.475021967731934 no 1588 0.480362547005478 2285 182073
SGTC_2778 tioconazole 65.09 nM 0.0492258055843605 0.475030173765673 no 1589 0.480369673154579 2298 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2464 5717415 7.67 µM 0.0486834129411774 0.475279050686132 no 1590 0.480585797377992 2314 5285744
SGTC_1627 st003713 25.6 µM 0.0484916866433367 0.475367026630195 no 1591 0.480662194873412 2268 16195070 YER133W GLC7
SGTC_2100 5377183 190 µM 0.0483462266557739 0.475433773516427 no 1592 0.480720157029564 2295 2844202
SGTC_843 0310-0051 143 µM 0.0481119534466138 0.475541275367656 no 1593 0.480813509883016 2248 2065037
SGTC_2335 9018011 154.17 µM 0.0477063503162978 0.475727400246063 no 1594 0.480975136523426 2289 6458208
SGTC_1907 st060210 83.7 µM 0.0476517634874638 0.475752449686013 no 1595 0.480996888778723 2285 688793
SGTC_1016 4226-1401 38 µM 0.0473348588143485 0.47589787648438 no 1596 0.481123172946607 2325 2901613
SGTC_1529 apigenin 74 µM 0.0468126330577135 0.476137531633721 no 1597 0.481331280174387 2319 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1513 0337-0559 19 µM 0.0467996782277098 0.476143476857923 no 1598 0.48133644274559 2232 775073
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.0454818187233535 0.476748295810052 no 1599 0.481861633228841 2223 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_3095 9117207 49.47 µM 0.0454582810754468 0.476759098678374 no 1600 0.481871013689587 2327 17015229
SGTC_3118 9124250 49.47 µM 0.0453052611416057 0.476829329314695 no 1601 0.481931996980836 2232 1504786
SGTC_3212 9128307 49.47 µM 0.0450563882021375 0.476943554563192 no 1602 0.482031181633743 2155 27243542
SGTC_183 3914-0051 30.55 µM 0.0448618674139754 0.477032835116523 no 1603 0.482108705810122 2309 1596232
SGTC_3230 9131665 49.47 µM 0.044326447598709 0.477278586397494 no 1604 0.482322095126983 2310 15943720
SGTC_1356 1502-0781 85.8 µM 0.0432772711578353 0.477760170784336 no 1605 0.482740254616218 2303 567702
SGTC_2427 5545055 42.75 µM 0.0430073445194162 0.477884075582515 no 1606 0.482847839596219 2300 5372858
SGTC_3129 9127257 49.47 µM 0.0424799553376698 0.478126169925881 no 1607 0.483058045323882 2221 837894
SGTC_355 1311-2252 105 µM 0.0416635460239314 0.478500952841444 no 1608 0.483383457385824 2276 5338538
SGTC_331 k048-0133 24.5 µM 0.0404663288692594 0.479050584652228 no 1609 0.483860675356215 2323 6813582
SGTC_195 4234-0266 16.654 µM 0.0403176232759628 0.47911885687825 no 1610 0.483919951929718 2285 2303354
SGTC_1183 1254-0324 198 µM 0.0399696031028542 0.479278638813698 no 1611 0.484058680064592 2313 5799357
SGTC_186 3455-3465 67.277 µM 0.0395930724642925 0.47945151413463 no 1612 0.484208775241369 2342 755278
SGTC_214 4373-3496 70 µM 0.0394539379969268 0.479515395482291 no 1613 0.48426423852629 2276 3779166
SGTC_1007 4101-0031 70 µM 0.0389936899828359 0.479726714678217 no 1614 0.484447709726749 2335 1146276
SGTC_463 ikarugamyin 104 µM 0.0379924036551113 0.480186466893102 no 1615 0.484846869331116 2343 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_659 k018-0002 107 µM 0.0378177433454933 0.480266666914502 no 1616 0.484916498673739 2335 6797879 YHR007C ERG11
SGTC_231 b-estradiol 524 µM 0.0354683682244105 0.481345522592818 no 1617 0.485853134498869 2324 450 A steroid.
SGTC_1115 galangin 695.678 nM 0.0353086037032778 0.48141889305027 no 1618 0.485916831423438 2350 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_229 benomyl 22.8748 µM 0.0339964323210635 0.482021519855623 no 1619 0.486439997826787 2281 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2692 st077426 47.7 µM 0.0329006110155774 0.482524817431206 no 1620 0.486876922770485 2341 25238571
SGTC_1785 bathophenanthroline 24 µM 0.0327484510200652 0.482594704911449 no 1621 0.48693759313258 2305 72812 An iron chelator.
SGTC_1807 st050092 58.9 µM 0.0326277658477113 0.482650136304282 no 1622 0.486985713834768 2322 5008496
SGTC_1738 st035555 74 µM 0.0324010577842667 0.482754265525854 no 1623 0.487076109471214 2321 5331140
SGTC_3315 9136395 68.55 µM 0.0322168367172077 0.482838880922862 no 1624 0.487149564694913 2346 16876844
SGTC_2353 9059630 146.67 µM 0.0320643858951176 0.482908904372139 no 1625 0.48721035236795 2319 4779114
SGTC_1583 clindamycin 39.6 µM 0.0319838154033604 0.482945912084849 no 1626 0.487242478865879 2272 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1649 st011737 51.3 µM 0.0315753222094295 0.483133543810386 no 1627 0.487405361799216 2304 1761035
SGTC_2731 amoxapine 43.43 µM 0.030032560632288 0.483842208344886 no 1628 0.488020542623436 2353 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1368 1852-0141 284 µM 0.0295387308180419 0.484069059002741 no 1629 0.488217464841095 2314 2838987
SGTC_2658 polymyxin b sulfate 77.05 µM 0.0285064319699126 0.484543282812281 no 1630 0.488629119072555 2342 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1169 aniline yellow 25.8 µM 0.0280428394670606 0.484756257948592 no 1631 0.488813991807675 2338 6051 A DNA damaging agent.
SGTC_2879 9041815 71.43 µM 0.0275041397935577 0.48500374289755 no 1632 0.489028819010019 2353 4942971
SGTC_776 4476-4378 112 µM 0.0269152167306354 0.485274307666997 no 1633 0.489263678359227 2236 2892008
SGTC_474 dl-dihydrosphingosine 5 µM 0.0260486839306265 0.485672425011089 no 1634 0.489609253723538 2345 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2557 derrustone 83.84 µM 0.0257137791835233 0.485826296535555 no 1635 0.489742816646179 2238 629853 An antioxidant.
SGTC_3073 9114972 49.47 µM 0.0246520872046831 0.486314103291643 no 1636 0.490166236162012 2362 41905075
SGTC_1003 4049-0218 100 µM 0.0240208019155228 0.486604164432148 no 1637 0.490418007982125 2340 295161
SGTC_1819 st053448 58.6 µM 0.0210652106714841 0.487962282717027 no 1638 0.491596818297828 2337 2857616
SGTC_2611 pyromycin 23.93 µM 0.0209539922285417 0.488013391322879 no 1639 0.49164117824566 2355 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2857 9024691 58.44 µM 0.0206637551228537 0.488146765935241 no 1640 0.491756941032163 2342 16478292
SGTC_2829 7992743 58.44 µM 0.0197138417034454 0.488583295238259 no 1641 0.492135824421693 2386 16462845
SGTC_134 0269-0018 6.916 µM 0.0194023428975762 0.488726446400068 no 1642 0.492260070699595 2343 4378915
SGTC_2506 ethyl hematommate 54.16 µM 0.0191167645934446 0.488857686914932 no 1643 0.492373978831137 2308 3940691 An allergen.
SGTC_2101 5377231 179.231 µM 0.0189096665470243 0.488952861757022 no 1644 0.492456584065552 2350 2844213
SGTC_2003 4023581 200 µM 0.0185500729704309 0.489118119572341 no 1645 0.492600015985502 2348 16641307
SGTC_868 0527-0199 213 µM 0.0183532117561728 0.489208591542699 no 1646 0.492678538878903 2276 2849450
SGTC_1731 st035964 63 µM 0.0176673375180748 0.48952380468362 no 1647 0.492952118732011 2270 6739575
SGTC_806 3966-4455 5.86 µM 0.0174269004400478 0.489634305984963 no 1648 0.493048024482088 2334 714982
SGTC_3308 9128332 17.569 µM 0.0171077155503902 0.489780999835856 no 1649 0.493175341847414 2371 17332805 YDL196W YDL196W
SGTC_308 4092-1169 104 µM 0.0167650319419756 0.489938494976587 no 1650 0.493312033221208 2373 2268590 YDL196W YDL196W
SGTC_2834 9001755 58.44 µM 0.0151277208972724 0.490691013630616 no 1651 0.493965142706286 2327 2989575
SGTC_739 1486-1183 203 µM 0.0149424824429398 0.490776152548226 no 1652 0.494039033805399 2370 4346692
SGTC_955 1216-0110 33 µM 0.0148164299434666 0.490834088779448 no 1653 0.494089315910463 2371 3619719
SGTC_3013 9080133 71.4286 µM 0.0137093745491011 0.491342921587476 no 1654 0.494530922171124 2368 17050193
SGTC_333 3486-0131 40.1 µM 0.0136716864295616 0.491360244326247 no 1655 0.494545956146497 2375 6744690
SGTC_2198 6589944 200 µM 0.0117055309026254 0.492263977958886 no 1656 0.495330275449159 2357 5290268
SGTC_1728 st035614 33.7865 µM 0.0114160324161933 0.492397047967117 no 1657 0.495445760917434 2327 15945546
SGTC_1671 st016596 74.5 µM 0.0109733786276565 0.49260051851426 no 1658 0.495622343162703 2383 2829167
SGTC_2593 nobiletin 86.24 µM 0.0108938014813587 0.492637097206163 no 1659 0.49565408795341 2376 72344 An anti-infammatory.
SGTC_3294 9122953 26.2835 µM 0.0104325800581687 0.492849104966981 no 1660 0.495838078217638 2382 16459826
SGTC_1638 st008370 60.6 µM 0.00978850252312172 0.493145168813825 no 1661 0.496095014841027 2394 24207134
SGTC_1213 1315-0166 115 µM 0.00930512085723695 0.493367367898594 no 1662 0.496287847435505 2370 768401
SGTC_3277 9138724 49.47 µM 0.00889445275874041 0.493556143900977 no 1663 0.496451673519014 2357 15943418
SGTC_1495 4469-0029 237 µM 0.00786606201134731 0.494028881026031 no 1664 0.496861927644783 2391 793680
SGTC_329 k048-0121 21.3 µM 0.00726421648600592 0.49430554509385 no 1665 0.497102022396919 2377 6832902
SGTC_2206 7254556 146.969 µM 0.0059545953996294 0.494907577791103 no 1666 0.497624474170664 2394 4398905
SGTC_1432 4049-0298 68.4 µM 0.00583637980722404 0.494961922079637 no 1667 0.497671634549071 2396 741646
SGTC_1425 4048-4433 7.33 µM 0.00560008833730548 0.495070546708293 no 1668 0.497765899665538 2393 23734946
SGTC_1994 st072947 40.9 µM 0.00445422378507935 0.495597312662933 no 1669 0.498223027681652 2365 5286565 YDL195W SEC31
SGTC_722 3534-0461 190 µM 0.00110890409302237 0.497135231776668 no 1670 0.499557611363048 2403 658262
SGTC_2849 9019321 12.99 µM 0 0.497645030584646 no 1671 0.5 2406 16489627
SGTC_2408 sulbentine 18.36 µM -0.000652393109289556 0.497944958489333 no 1672 0.499739732823724 2418 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1750 st081859 2.357 µM -0.00126758013036119 0.498227782522454 no 1673 0.499494308827623 2408 5291695
SGTC_645 0845-0943 5.41 µM -0.00217991743604105 0.498647219036045 no 1674 0.499130339455756 2408 1885106
SGTC_2242 6630449 61.2675 µM -0.00261394881757749 0.498846760492012 no 1675 0.498957186485407 2434 691249 YDR170C SEC7
SGTC_2126 5251174 33.877 µM -0.00337196923316229 0.499195253230579 no 1676 0.498654781453908 2416 790722
SGTC_1336 1486-0901 104 µM -0.00342541998298916 0.499219826735103 no 1677 0.498633457813042 2428 5006114
SGTC_2911 7942208 15.64 µM -0.00468379370457917 0.499798353459831 no 1678 0.498131443490609 2424 1243384
SGTC_2334 9017922 200 µM -0.00556100989118489 0.499798353459831 no 1679 0.497781489467192 2420 3163164
SGTC_2390 9097792 176.6 µM -0.00584706801209235 0.499666840566005 no 1680 0.497667370645003 2419 4497149
SGTC_233 rapamycin 362 pM -0.00601919602355298 0.499587706129638 no 1681 0.497598702712311 2417 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2784 7567673 72.73 µM -0.00640524649389836 0.499410222667422 no 1682 0.497444693830038 2413 3471247
SGTC_3009 9080819 71.4286 µM -0.00822295303952394 0.498574549498013 no 1683 0.49671955333179 2428 17027216
SGTC_1025 k007-0731 70 µM -0.010617050162906 0.497473896418289 no 1684 0.495764489369388 2428 6256118
SGTC_533 1222-0222 6.71 µM -0.0115739781385872 0.497033966910549 no 1685 0.49538275385369 2490 3982874
SGTC_600 1495-0418 41.6 µM -0.0116756709229874 0.496987215782151 no 1686 0.49534218704352 2432 5377768
SGTC_1081 sertraline 6 µM -0.0122528973300075 0.49672184883035 no 1687 0.495111923508614 2427 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2485 5633444 17.78 µM -0.0125493215771257 0.496585574957865 no 1688 0.494993676436747 2444 5724239
SGTC_1602 st001878 87.6 µM -0.0133681361515296 0.496209146896044 no 1689 0.494667044118947 2457 595405 YLR310C CDC25
SGTC_1291 0993-0025 5.79 µM -0.0140126996453191 0.495912828457286 no 1690 0.494409924590091 2438 4353356
SGTC_12 0849-0099 9.267 µM -0.0143377567293143 0.495763394206297 no 1691 0.49428025860432 2432 6071388
SGTC_1417 3966-0327 90.4 µM -0.0144224675724886 0.495724451292701 no 1692 0.494246467361365 2432 651118
SGTC_3143 9086658 49.47 µM -0.0146019541909699 0.495641938592196 no 1693 0.494174870100324 2467 25236626
SGTC_1400 3771-8998 51.5 µM -0.0148560353452524 0.495525133980248 no 1694 0.494073517379993 2435 670767
SGTC_3283 9109332 35.8195 µM -0.0148605481714845 0.495523059375207 no 1695 0.494071717221525 2424 17027281
SGTC_2594 a-mangostin 100 µM -0.0150587640697574 0.49543193706341 no 1696 0.49399264936703 2460 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1343 1487-0095 224 µM -0.015103129524727 0.495411541744876 no 1697 0.493974952123855 2427 4560101 YGL055W OLE1
SGTC_440 fluspirilene 35.1 µM -0.0154442821947379 0.49525471027713 no 1698 0.493838867774594 2535 3396 An atypical antipsychotic.
SGTC_1476 4112-3294 3.34 µM -0.0159079273955843 0.495041568885965 no 1699 0.493653922828134 2459 704369
SGTC_2443 5493264 126.67 µM -0.0166133296438136 0.494717292590113 no 1700 0.493372545254163 2447 5340055
SGTC_2447 5741742 33.78 µM -0.0168576610366967 0.494604973253495 no 1701 0.49327508478052 2454 1776504
SGTC_147 4466-0538 29.23 µM -0.0175542937192408 0.494284733030757 no 1702 0.492997209690063 2492 6742687 YHR072W ERG7
SGTC_1275 0867-0008 21.1 µM -0.018332055048409 0.49392720254231 no 1703 0.492686977764383 2437 3422836
SGTC_38 0929-0051 58.268 µM -0.0186566459770789 0.493777992187363 no 1704 0.492557506863742 2456 1379719
SGTC_2372 9071633 200 µM -0.0186827335510153 0.493766000096255 no 1705 0.492547101241142 2440 21321366
SGTC_926 2268-1401 59.4 µM -0.0187230823416746 0.493747452335343 no 1706 0.492531007217667 2437 2931578
SGTC_2155 5570423 76 µM -0.0201634633715793 0.493085338973001 no 1707 0.491956486980931 2450 797402
SGTC_179 1273-0063 6.77 µM -0.0215740171126794 0.492436955048233 no 1708 0.491393880023679 2444 3108139
SGTC_631 k072-0230 41.5 µM -0.0216755267100078 0.492390295264295 no 1709 0.491353393021046 2465 5773147
SGTC_1647 st011722 22.4 µM -0.0226774639793171 0.491929751626589 no 1710 0.490953776175974 2469 2854783
SGTC_3008 9078912 71.4286 µM -0.0229595113386886 0.491800109578838 no 1711 0.490841284849613 2456 16648731
SGTC_942 3253-1115 227 µM -0.0232415460876108 0.491670474193537 no 1712 0.490728799281188 2474 46497897
SGTC_64 000l-0018 272.079 µM -0.0237053372841877 0.491457297592478 no 1713 0.4905438243331 2468 6811119
SGTC_194 1486-1323 56.904 µM -0.0240368480597875 0.491304923746224 no 1714 0.490411608344533 2463 5178754
SGTC_2277 7947813 106.88 µM -0.024136480164956 0.491259129623309 no 1715 0.49037187241373 2596 1246798
SGTC_1263 0774-1208 64.8 µM -0.0243233967677009 0.491173217046723 no 1716 0.490297325364217 2456 906585
SGTC_1612 st002233 45.4 µM -0.0249793951152961 0.490871703447398 no 1717 0.490035699398171 2449 1035021
SGTC_2002 4023503 131 µM -0.0250824687475293 0.490824328642563 no 1718 0.489994591848231 2439 4736863 YCR052W RSC6
SGTC_3049 9092223 49.47 µM -0.0254028876080145 0.490677058238478 no 1719 0.489866803937147 2493 8623917
SGTC_1575 cyproterone acetate 48 µM -0.027076604708613 0.489907808179388 no 1720 0.489199317328097 2467 9880 An androgen receptor antagonist and liver toxin.
SGTC_459 nigericin 15.3 µM -0.0279410006460158 0.489510541326187 no 1721 0.488854603705364 2478 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2164 5685496 200 µM -0.0284029058201522 0.489298259036121 no 1722 0.488670403314151 2459 759046
SGTC_2111 5486399 200 µM -0.0291841412621108 0.488939225934924 no 1723 0.488358864643311 2447 689674
SGTC_3312 9133330 71.43 µM -0.0296474366730767 0.488726313045535 no 1724 0.488174116464756 2474 17617324
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.0305010849202162 0.488334017348366 no 1725 0.487833714071898 2461 688664
SGTC_2940 9060638 45.86 µM -0.0311690444276655 0.488027063121185 no 1726 0.487567363441084 2487 4027022
SGTC_2156 5649887 115 µM -0.0317924928542088 0.487740569919157 no 1727 0.487318766723131 2501 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2518 prenyletin 46.28 µM -0.0318461320277062 0.487715921407808 no 1728 0.487297378619073 2479 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1829 berberine 14.4 µM -0.0323670543510818 0.487476547321866 no 1729 0.48708966776705 2522 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1835 st008666 49.2 µM -0.0328058568864319 0.487274912396184 no 1730 0.486914703804131 2474 690455
SGTC_2469 5655019 90.81 µM -0.0354381557501809 0.486065410196077 no 1731 0.485865179959682 2512 2788239
SGTC_794 k038-0031 316 µM -0.035730725655544 0.485930986384734 no 1732 0.485748535329031 2453 6624242
SGTC_1218 1348-1416 30.7 µM -0.0363570953781838 0.485643200711609 no 1733 0.485498812235846 2469 6787668
SGTC_1673 st016611 27.3 µM -0.0367448537247517 0.48546504881249 no 1734 0.48534422233631 2565 5226799
SGTC_1631 benzylvanillin 81.9 µM -0.0368518598383799 0.485415886376484 no 1735 0.485301561966732 2534 75506
SGTC_757 1066-0008 322 µM -0.0372017956854305 0.485255114883553 no 1736 0.485162053427538 2598 6842497
SGTC_952 1185-0122 232 µM -0.0386816173634986 0.484575265245684 no 1737 0.484572114829216 2463 678600
SGTC_254 nsc-64875 3.808 µM -0.0398838056102022 0.484022996992256 no 1738 0.484092881040484 2497 56993
SGTC_1950 st077106 7.18 µM -0.0399825174090515 0.483977651537191 no 1739 0.484053532116901 2528 13831864
SGTC_2695 st077686 51.995 µM -0.0405241928806658 0.48372882459448 no 1740 0.483837609875461 2497 2876092
SGTC_2971 9092186 9.93 µM -0.041249645277522 0.483395586843549 no 1741 0.483548438059387 2495 25236400
SGTC_801 0866-0028 10.1 µM -0.0412939563655913 0.483375232845907 no 1742 0.483530775542101 2483 6849771
SGTC_3273 9137859 49.47 µM -0.0431597145827429 0.482518249444855 no 1743 0.482787109125575 2475 2377234
SGTC_2467 5474540 200 µM -0.0434660584551007 0.482377546643477 no 1744 0.482665010185938 2484 5413519
SGTC_133 0724-0033 378.92 µM -0.0437623445023007 0.482241465458144 no 1745 0.48254692152252 2476 280309
SGTC_1223 0764-0573 147 µM -0.0441031077979551 0.482084958881483 no 1746 0.482411107766201 2497 1609797
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.0449055783388027 0.481716409252482 no 1747 0.482091285230237 2469 368090
SGTC_1255 0566-0045 221 µM -0.0463499304760015 0.481053103057992 no 1748 0.481515671639526 2552 2788469
SGTC_1318 1280-3875 124 µM -0.0464148421744202 0.481023294141283 no 1749 0.481489803458951 2530 373245
SGTC_1350 1495-0454 146 µM -0.0466742926431864 0.480904149692571 no 1750 0.481386409754152 2516 1069057
SGTC_1023 4482-3888 16 µM -0.0468867975006801 0.480806564806151 no 1751 0.481301725295137 2477 3303168
SGTC_1298 1079-1278 263 µM -0.0480378409462042 0.480278011407209 no 1752 0.480843042345551 2497 2840950
SGTC_3 0833-0587 95.581 µM -0.0495945210476615 0.47956324701014 no 1753 0.4802227564158 2428 5382644
SGTC_993 3909-8757 62.7 µM -0.0499297712095139 0.479409322247549 no 1754 0.480089176444897 2534 4288324 YLR208W SEC13
SGTC_2123 5259487 200 µM -0.05073273317492 0.47904066760123 no 1755 0.479769246461577 2520 2173474
SGTC_2244 6635614 200 µM -0.0509698680829782 0.478931798007075 no 1756 0.479674765556768 2504 836499
SGTC_2569 tetrandrine 100 µM -0.051128321522278 0.478859052268634 no 1757 0.479611634094652 2538 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_618 k072-0232 33.2 µM -0.0516512263885692 0.478618992431797 no 1758 0.479403300513936 2533 5872756 YGL099W LSG1
SGTC_1925 st057770 10.1 µM -0.0519840408956553 0.478466205009014 no 1759 0.479270704869793 2504 5989122
SGTC_3165 9101544 49.47 µM -0.0523553128987431 0.478295766376777 no 1760 0.479122790195951 2533 5002184
SGTC_685 1278-0033 54.9 µM -0.0523855341111148 0.478281892997275 no 1761 0.479110750198715 2491 3590572
SGTC_914 3820-6779 408 µM -0.0524137300451908 0.478268949367752 no 1762 0.479099517080574 2507 2893481
SGTC_748 act1.228 77.9 µM -0.0525198409726209 0.478220238275807 no 1763 0.47905724317033 2499 4421505 YNR035C ARC35
SGTC_1557 sumaresinolic acid 42.3 µM -0.0527013985336242 0.478136893542612 no 1764 0.478984912353731 2483 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_824 1304-0008 100 µM -0.0533244262141667 0.477850897456697 no 1765 0.478736709290352 2501 768245
SGTC_37 0566-0070 1.56 µM -0.0536104308204411 0.477719613043187 no 1766 0.478622772936039 2564 1626686
SGTC_2932 9016711 44.54 µM -0.0537329139686827 0.477663390462564 no 1767 0.478573979558518 2504 7117328
SGTC_399 oxolinic acid 75 µM -0.0545469621151917 0.477289734999497 no 1768 0.478249696949676 2514 4628 A DNA gyrase inhibitor.
SGTC_1062 mesoridazine 14.2 µM -0.0545873516983213 0.477271196332629 no 1769 0.478233607808428 2498 4078 A neuroleptic.
SGTC_3234 9132280 49.47 µM -0.0578539887973836 0.475771988572391 no 1770 0.476932466658108 2569 17612295
SGTC_3293 9120939 62.045 µM -0.0592318653240058 0.47513972021408 no 1771 0.476383714665783 2550 934087
SGTC_2544 sphondin 68.51 µM -0.0592788945453124 0.475118140937449 no 1772 0.476364985630566 2595 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2973 9094665 17.96 µM -0.0595728083763986 0.474983280741784 no 1773 0.476247937832701 2599 25237061 YIL048W NEO1
SGTC_557 1315-0110 16.2 µM -0.0599908307026399 0.474791479218538 no 1774 0.476081468788782 2517 6833801
SGTC_2272 7805186 180 µM -0.0603735287078669 0.474615890703601 no 1775 0.47592907060993 2510 2956062 YPR165W RHO1
SGTC_327 1273-0057 3.96 µM -0.0620255291565589 0.473857981116144 no 1776 0.475271250905717 2517 3108138
SGTC_535 2293-4129 48.2 µM -0.0625029780452755 0.473638953224095 no 1777 0.475081145220871 2505 396118 YIL048W NEO1
SGTC_2896 9052656 71.43 µM -0.0628774949810689 0.473467150554174 no 1778 0.47493202788987 2524 6469436
SGTC_490 phenamil 164 µM -0.0630411380800795 0.47339208387732 no 1779 0.47486687299984 2589 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2195 6536160 144.242 µM -0.0630772591352637 0.473375514484677 no 1780 0.474852491406094 2524 3834386
SGTC_2960 9079389 5.97 µM -0.0634107678610928 0.473222530075399 no 1781 0.4747197064977 2543 16457355
SGTC_2893 9048488 25.97 µM -0.0643820499086286 0.472777014058519 no 1782 0.474333011234431 2542 6467338
SGTC_736 0958-0254 92.6 µM -0.0663766437457693 0.471862223955285 no 1783 0.473538982388534 2585 6812352
SGTC_1757 st041620 31.8375 µM -0.0667501327609973 0.471690945256198 no 1784 0.473390311551842 2565 5289815
SGTC_3302 9125395 16.351 µM -0.0667651206857956 0.471684072037907 no 1785 0.473384345543766 2557 17599668
SGTC_1695 st026914 34.495 µM -0.0669785739721388 0.471586186752326 no 1786 0.473299380191556 2521 3289191
SGTC_583 1488-1091 88.9 µM -0.0670203630499912 0.471567023341699 no 1787 0.473282746138014 2502 4303273
SGTC_1507 4075-3230 155 µM -0.0673367422250565 0.471421942019667 no 1788 0.473156813593949 2501 659771
SGTC_9 0092-0002 10.449 µM -0.0674633953650931 0.471363864021856 no 1789 0.473106400938151 2526 759368
SGTC_1816 st051957 91.6 µM -0.0674811217528943 0.471355735467268 no 1790 0.473099345211489 2522 674121
SGTC_727 3032-0951 202 µM -0.0690339074064598 0.470643741823528 no 1791 0.472481314831141 2576 3652836
SGTC_1227 3909-8010 46.6 µM -0.0691242244288737 0.470602331925116 no 1792 0.472445369418937 2551 15982272
SGTC_2856 9022925 19.48 µM -0.0692658022822966 0.470537419834593 no 1793 0.472389023080599 2624 4944862
SGTC_2783 7738165 71.43 µM -0.0693080024881006 0.47051807159557 no 1794 0.472372227996555 2579 17201110
SGTC_1268 0828-0275 2.46 µM -0.0702953740407681 0.470065394693617 no 1795 0.471979282190769 2611 745337
SGTC_1539 benzyladenosine 56 µM -0.0704163562310957 0.47000993104591 no 1796 0.471931136586593 2529 92208 A nucleotide analog.
SGTC_1423 4048-0112 5.59 µM -0.0715477337530296 0.469491285289158 no 1797 0.4714809179141 2565 X1423
SGTC_201 4262-0159 12.803 µM -0.0720113714981513 0.469278759510101 no 1798 0.471296429100384 2572 1341029
SGTC_1101 ebselen 5.29 µM -0.0721831466179624 0.469200022149387 no 1799 0.471228078616913 2524 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_961 1252-1571 372 µM -0.072445064083321 0.469079968141977 no 1800 0.471123861515651 2565 6813498
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.0726967208685811 0.468964619927479 no 1801 0.471023729007245 2613 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2803 7707263 71.43 µM -0.0733457068146642 0.468667165841558 no 1802 0.47076551042035 2559 2199229
SGTC_2959 9079155 11 µM -0.0736528072896041 0.468526416505121 no 1803 0.470643325533144 2645 16189457
SGTC_3345 9148410 3.559 µM -0.073659593938078 0.468523306113821 no 1804 0.470640625386535 2562 4903596
SGTC_700 3453-2283 142 µM -0.0744941062790192 0.468140855165222 no 1805 0.47030861532327 2617 565664
SGTC_1046 2001-0062 216 µM -0.0747315943386419 0.46803202147029 no 1806 0.470214134652385 2550 739778
SGTC_1454 4239-0054 42.6 µM -0.0752547626706636 0.467792277467343 no 1807 0.470006006764186 2702 1340767
SGTC_359 0081-0058 15.9 µM -0.0758201351763205 0.467533206367079 no 1808 0.469781098339849 2689 3494159
SGTC_1138 3761-0006 1.03 µM -0.0770423059366538 0.466973217210494 no 1809 0.469294944844756 2519 12061087
SGTC_2532 xanthone 78.9 µM -0.0772460389051835 0.46687987467203 no 1810 0.469213908641225 2592 7020 An insecticide.
SGTC_1922 5578187 25 µM -0.0778089638661403 0.466621973789356 no 1811 0.468990007967661 2627 1350412
SGTC_2722 naftopidil 47.16 µM -0.0779608194360849 0.466552404415628 no 1812 0.468929609827704 2537 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.0796342073071118 0.465785845783118 no 1813 0.468264094052049 2543 3256 An antibiotic and ribosome inhibitor.
SGTC_538 2922-0838 53.3 µM -0.0800422201862895 0.465598959183371 no 1814 0.468101838409764 2539 777039
SGTC_3031 9088762 49.47 µM -0.080611905903802 0.465338032506449 no 1815 0.467875298740276 2536 205253
SGTC_3236 9132701 49.47 µM -0.081591827041514 0.464889245285082 no 1816 0.467485650350661 2564 24282524
SGTC_3001 9076041 71.4286 µM -0.0817873537789143 0.464799702689837 no 1817 0.467407906301898 2557 16004211
SGTC_3183 9108214 49.47 µM -0.0818521224717294 0.464770041886829 no 1818 0.467382153676403 2539 4974831
SGTC_157 1348-1695 65.819 µM -0.082029674815039 0.464688732850027 no 1819 0.467311557938899 2555 5380510
SGTC_2287 7945887 168.79 µM -0.0826738596275179 0.464393744660864 no 1820 0.467055435347201 2593 1245853
SGTC_2246 7293507 91.5585 µM -0.0828187186734918 0.464327412803448 no 1821 0.466997842454779 2708 887656
SGTC_537 1334-0398 209 µM -0.0831875688073545 0.464158518515404 no 1822 0.466851198566282 2547 5846986
SGTC_1732 st034308 51.822 µM -0.0832387335202503 0.464135091006291 no 1823 0.466830857346761 2523 830119
SGTC_1136 pergolide 1.05886 µM -0.0838617747802384 0.463849820313209 no 1824 0.466583165883283 2579 47811 A dopamine receptor agonist.
SGTC_2993 9054257 71.4286 µM -0.0845106423865378 0.46355274431961 no 1825 0.466325220855927 2562 6470217 YGL055W OLE1
SGTC_2969 9091408 28.7 µM -0.0846649369956575 0.463482105429273 no 1826 0.466263886033961 2602 4286311
SGTC_1315 1237-0019 3.69 µM -0.0851274343273839 0.463270372609727 no 1827 0.466080040013034 2567 825140
SGTC_958 1222-0007 33 µM -0.0853034962119412 0.463189773623287 no 1828 0.466010056045695 2658 7312461
SGTC_1184 1269-1718 139 µM -0.0854642667663391 0.463116176141343 no 1829 0.465946151245265 2641 5403821
SGTC_780 0109-0199 192 µM -0.0855160959702802 0.463092450057472 no 1830 0.46592554980572 2614 610414
SGTC_1740 st038286 13.222 µM -0.0857828221902593 0.462970351694505 no 1831 0.465819531021512 2660 716786
SGTC_2043 5101342 149 µM -0.0858863154543069 0.462922976870517 no 1832 0.465778394998552 2587 678451
SGTC_3127 9126946 49.47 µM -0.085912007093075 0.462911216410102 no 1833 0.465768183261674 2660 27243249
SGTC_760 0568-0725 82.9 µM -0.0860120321491119 0.462865429810546 no 1834 0.465728426201215 2615 3916171
SGTC_1031 k035-0009 16 µM -0.0866763515798743 0.462561349239767 no 1835 0.465464387181801 2688 5180959
SGTC_702 1488-0190 94 µM -0.0874638756080488 0.462200902279222 no 1836 0.465151399222532 2597 949357
SGTC_690 glyoxal 20.3 µM -0.0881407228700517 0.46189113647446 no 1837 0.464882415070525 2569 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2776 terbinafine 19.92 µM -0.0898425098640804 0.461112399459833 no 1838 0.464206183387228 2542 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2186 6124449 200 µM -0.0905655580880247 0.460781577852976 no 1839 0.463918900045821 2637 3834182 YLR033W RSC58
SGTC_3192 9110362 49.47 µM -0.0909993293563529 0.46058312428406 no 1840 0.463746561971394 2559 16649480
SGTC_2823 7987624 58.44 µM -0.0911610717557027 0.460509128448238 no 1841 0.463682303176082 2655 2239440
SGTC_788 1182-0090 188 µM -0.0914333123225209 0.460384583686346 no 1842 0.463574146596583 2786 5715185
SGTC_2168 5727979 200 µM -0.0922544608307019 0.460008947811663 no 1843 0.463247934501177 2554 695210
SGTC_1148 3909-7663 27.7 µM -0.0951541207805183 0.458682780893337 no 1844 0.462096205440863 2721 4084526
SGTC_3130 9127414 49.47 µM -0.095633260808357 0.458463688836044 no 1845 0.46190592397646 2556 1494646
SGTC_1919 st067113 52.3 µM -0.0965649941249646 0.458037679695158 no 1846 0.461535928587767 2683 1268243
SGTC_2333 9017922 200 µM -0.0965769257318121 0.458032224611362 no 1847 0.46153119070952 2689 3163164
SGTC_902 1120-0002 2.07 µM -0.09692532618324 0.457872940782879 no 1848 0.461392848054871 2595 3280475
SGTC_39 0986-0283 58.349 µM -0.0971106257100614 0.457788227177387 no 1849 0.461319271325314 2635 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_605 1315-0399 119 µM -0.097283403044264 0.457709240085157 no 1850 0.461250667965136 2670 24020461
SGTC_792 4534-1957 155 µM -0.0983235414240995 0.457233764586886 no 1851 0.460837692698794 2647 1717904
SGTC_412 gemfibrozil 100 µM -0.0983707070320432 0.457212205352349 no 1852 0.460818967121294 2564 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.0988660619025757 0.456985787990486 no 1853 0.460622307764309 2760 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1166 k206-0078 225 µM -0.0988884231421177 0.456975567418768 no 1854 0.460613430422248 2567 5404595
SGTC_1140 3229-1848 2.98 µM -0.0993731067840048 0.456754041806509 no 1855 0.46042101736594 2623 2849525
SGTC_2789 5281112 71.43 µM -0.0995168572464648 0.456688342955649 no 1856 0.460363952095365 2629 765948
SGTC_3288 9119690 36.221 µM -0.0996961219212036 0.456606414560778 no 1857 0.460292789731401 2615 17595618 YKL019W RAM2
SGTC_2493 resveratrol 26.09 µM -0.101180950313999 0.455927882458843 no 1858 0.459703409275617 2570 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1005 4092-0690 4.4 µM -0.101397249929358 0.455829049233945 no 1859 0.459617559731368 2639 1529343
SGTC_593 1203-0218 61.7 µM -0.10241879991825 0.455362312073057 no 1860 0.459212130980683 2663 3666956
SGTC_1987 st072290 61.9 µM -0.103065245417002 0.455066988624218 no 1861 0.458955594114881 2640 54697379
SGTC_283 0987-0079 11.7 µM -0.103107048326889 0.455047892152663 no 1862 0.458939005542599 2604 411556
SGTC_2129 girgensonine 121.053 µM -0.103125193063863 0.455039603277486 no 1863 0.45893180522206 2646 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1710 st031758 61.5 µM -0.103243529247625 0.454985545445565 no 1864 0.458884846566357 2737 5394341
SGTC_592 k241-0073 46.5 µM -0.103499674525097 0.45486853710611 no 1865 0.458783203899772 2604 4230158
SGTC_100 0086-0128 49.5915 µM -0.10508013900325 0.454146660671532 no 1866 0.458156109411764 2611 93297
SGTC_900 1112-0045 141 µM -0.105129728809784 0.454124012987827 no 1867 0.458136434914493 2631 56211 YIL048W NEO1
SGTC_3039 9090270 49.47 µM -0.105379060247019 0.454010145486433 no 1868 0.458037515521623 2608 17173750
SGTC_3087 9117406 49.47 µM -0.105398384653592 0.454001320355544 no 1869 0.458029848893025 2700 42546093
SGTC_94 0334-0113 514.748 µM -0.105492884464349 0.453958164211341 no 1870 0.457992357930394 2598 6795178
SGTC_1655 st012546 55.1 µM -0.106332197675585 0.453574890828005 no 1871 0.457659393171132 2681 720985 YLR208W SEC13
SGTC_639 0833-0042 114 µM -0.106493965786404 0.453501024185095 no 1872 0.457595221395071 2615 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2910 7948405 25.97 µM -0.107361104626023 0.453105098261047 no 1873 0.457251255060192 2649 2971328
SGTC_482 fipronil 114 µM -0.10777897921045 0.452914318005378 no 1874 0.457085508951322 2580 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_217 ketoconazole 989 nM -0.107840054012202 0.452886435270308 no 1875 0.457061284817736 2628 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_3016 9080866 49.47 µM -0.109051195654807 0.452333555858529 no 1876 0.456580942083061 2606 17066299
SGTC_2022 5136654 200 µM -0.112265759939565 0.450866576154609 no 1877 0.455306344873126 2730 1713771
SGTC_167 3672-0051 66.205 µM -0.11445836544392 0.449866355197792 no 1878 0.454437224500622 2606 3237971
SGTC_2223 6903751 107.57 µM -0.11547507125935 0.449402662850119 no 1879 0.454034289267046 2705 5598863
SGTC_1139 k015-0024 46.9 µM -0.116289708178008 0.449031178549035 no 1880 0.45371147097849 2590 2766652
SGTC_2756 carbadox 75.1 µM -0.116928897598256 0.448739731694532 no 1881 0.453458199125902 2646 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_151 3013-0144 2.285 µM -0.117182987812698 0.448623883581159 no 1882 0.453357523895409 2860 906558 YHR107C CDC12
SGTC_3270 9137563 49.47 µM -0.117619907604388 0.448424687678478 no 1883 0.453184415225996 2751 17015724
SGTC_1831 st055328 12 µM -0.118254815161389 0.448135250452567 no 1884 0.452932879193812 2636 1103068
SGTC_1501 4491-0275 38.4 µM -0.118814557342076 0.447880101987853 no 1885 0.452711137646118 2612 5104718
SGTC_2999 9069765 71.4286 µM -0.119677963975317 0.447486575831573 no 1886 0.452369128538687 2686 2097066
SGTC_323 4013-0906 34.3 µM -0.120662414391198 0.447037943050694 no 1887 0.451979215193795 2733 2910086
SGTC_2271 7849410 118.62 µM -0.120712073936201 0.447015314041979 no 1888 0.451959547657374 2585 972430
SGTC_1881 5652484 16 µM -0.120869353948477 0.446943645358323 no 1889 0.451897258087007 2664 2255129
SGTC_1790 st045711 43.5 µM -0.121131489941396 0.446824200201224 no 1890 0.451793443723391 2629 585119
SGTC_24 0417-1663 219 µM -0.121527818306702 0.446643617972583 no 1891 0.451636491085425 2681 4329390
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.122031913586397 0.446413949042159 no 1892 0.451436871878623 2680 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2837 9008476 45.46 µM -0.122242937494918 0.446317810575717 no 1893 0.451353311110662 2815 2992805
SGTC_2836 9010338 19.48 µM -0.122594124719786 0.446157823374688 no 1894 0.451214253571429 2643 2994051
SGTC_1892 st058411 7.36 µM -0.122853817536373 0.446039523092931 no 1895 0.451111428384161 2739 3934738
SGTC_1928 4'-methoxychalcone 40.3 µM -0.123458291560865 0.445764180043852 no 1896 0.450872100037661 2833 641818
SGTC_1073 triclabendazole 3.09 µM -0.123582758386112 0.445707487591394 no 1897 0.450822822319104 2673 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_3072 9116419 49.47 µM -0.123932969339694 0.445547978613614 no 1898 0.450684174207129 2693 17170162
SGTC_442 cape 100 µM -0.124358341051463 0.445354248366496 no 1899 0.450515778132772 2656 5281787
SGTC_1605 st000082 49.1 µM -0.124842669663858 0.445133682822864 no 1900 0.45032405305836 2756 1114022
SGTC_3174 9107204 49.47 µM -0.125159990953113 0.444989182409816 no 1901 0.450198445354609 2717 3938802
SGTC_1415 3966-0071 78.1 µM -0.125538649632158 0.444816760005156 no 1902 0.450048564533675 2637 2893185
SGTC_1591 genipin 88.4 µM -0.12591427829436 0.44464572763551 no 1903 0.449899890094415 2788 442424 A DNA cross-linking agent.
SGTC_1963 st076565 50.3 µM -0.126179166659194 0.444525124064574 no 1904 0.44979505107259 2632 4914280
SGTC_708 3448-5400 146 µM -0.126466513094224 0.444394301150685 no 1905 0.449681327430626 2631 3462195
SGTC_1756 st041558 35.5 µM -0.127805926761493 0.443784573848774 no 1906 0.449151279827628 2728 3955792
SGTC_75 0159-0059 199.013 µM -0.129401998915571 0.443058184430039 no 1907 0.448519783037346 2876 5377270
SGTC_2970 9090938 41.86 µM -0.129638371913791 0.442950624771025 no 1908 0.448426271503664 2700 17217104
SGTC_1610 st001799 48.1 µM -0.1299446530842 0.442811260206612 no 1909 0.448305107857173 2630 621897
SGTC_2502 avocadyne acetate 18.59 µM -0.130986134619571 0.442337416595308 no 1910 0.447893137934058 2608 3952079
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.132477691197553 0.441658945832326 no 1911 0.447303233667234 2678 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1854 st056233 32.9 µM -0.133649131944938 0.441126207421051 no 1912 0.44684001549699 2634 5393174
SGTC_411 enrofloxacin 100 µM -0.135001216274101 0.440511449847479 no 1913 0.446305456344006 2772 71188 A bacterial gyrase inhibitor.
SGTC_1057 3448-5381 134 µM -0.13704062758328 0.439584454225304 no 1914 0.44549934093278 2769 5497911
SGTC_2096 5468907 200 µM -0.137382564181019 0.439429062374168 no 1915 0.44536420606719 2782 759785
SGTC_1337 1486-1011 40.3 µM -0.138327378848006 0.438999743354868 no 1916 0.444990844155302 2658 X1337
SGTC_2524 avocatin b 10.57 µM -0.140002392818415 0.438238802124323 no 1917 0.444329049907171 2760 6710748
SGTC_2004 4023728 41.89 µM -0.140355903861085 0.438078234855254 no 1918 0.444189398259929 2718 360084 YDR527W RBA50
SGTC_1294 1000-1494 117 µM -0.142248730428199 0.437218673413753 no 1919 0.443441770896145 2671 712797 YDL207W GLE1
SGTC_1302 1159-0335 255 µM -0.143173775225019 0.436798703965986 no 1920 0.443076470380137 2647 649284
SGTC_1893 st059353 36.1 µM -0.143218350012744 0.436778468850088 no 1921 0.443058869000067 2704 3112488
SGTC_1895 st058434 18.3 µM -0.143524891446748 0.436639316160275 no 1922 0.442937827110223 2761 5393175
SGTC_3225 9130819 49.47 µM -0.143964877983497 0.436439600553836 no 1923 0.442764101988285 2676 4547121
SGTC_3064 1327-0027 10 µM -0.144840537608606 0.436042175529563 no 1924 0.442418387649322 2661 16000455 YPR107C YTH1
SGTC_2162 5663267 200 µM -0.144971088314931 0.435982929583445 no 1925 0.442366849395516 2692 6456493
SGTC_260 nsc-65238 3.989 µM -0.146688162263717 0.43520382883912 no 1926 0.441689081335308 2773 3246252
SGTC_2809 7964133 12.99 µM -0.146875610668178 0.435118791650209 no 1927 0.441615101494424 2710 1253665
SGTC_3027 9089541 49.47 µM -0.146965115247066 0.435078188373591 no 1928 0.441579777641546 2763 9943819
SGTC_1039 k821-0043 94 µM -0.148071454728776 0.434576360005428 no 1929 0.441143188455532 2743 15992768
SGTC_666 0272-0154 136 µM -0.14821554470922 0.434511009470437 no 1930 0.441086332203614 2714 6870312
SGTC_1374 2889-5571 141 µM -0.148821336230602 0.434236278526287 no 1931 0.440847307121856 2726 2853281
SGTC_959 1222-0044 107 µM -0.149738903697426 0.433820215405721 no 1932 0.440485306740267 2705 6083612
SGTC_1511 0906-3109 28.5 µM -0.149741276220586 0.433819139700217 no 1933 0.440484370792462 2656 2882180
SGTC_2461 5755302 26.15 µM -0.150528773507971 0.433462114397566 no 1934 0.440173725691906 2837 2788904
SGTC_611 3453-1652 23.7 µM -0.15107761339461 0.4332133205763 no 1935 0.43995724585599 2710 1560575
SGTC_2438 5259590 200 µM -0.151124482804923 0.433192075496387 no 1936 0.439938759906919 2801 1201127
SGTC_962 1254-0300 21.5 µM -0.151231572567551 0.433143534313836 no 1937 0.439896522702491 2663 7340576
SGTC_3271 9137798 49.47 µM -0.151703338460415 0.432929706337439 no 1938 0.439710461970678 2768 6498326
SGTC_1883 5-benzylidenerhodanine 20 µM -0.151782978666092 0.432893611335325 no 1939 0.439679053816851 2763 1273210
SGTC_2707 st078556 66.6 µM -0.151861271587256 0.432858127503172 no 1940 0.43964817736924 2757 17250899
SGTC_2102 5377816 72.7585 µM -0.152159500514965 0.432722969475639 no 1941 0.43953056793095 2832 1379702
SGTC_1050 3232-1156 69.3 µM -0.152973030418165 0.432354315940014 no 1942 0.439209771775437 2716 700529
SGTC_671 0560-0003 407 µM -0.153273566971953 0.432218141769457 no 1943 0.43909127242481 2760 3238678
SGTC_473 2-arachidonoylglycerol 10 µM -0.153829336620922 0.431966341809248 no 1944 0.438872150931921 2642 5282280 An endocannabinoid.
SGTC_1455 4262-0120 131 µM -0.155031766466236 0.431421657240447 no 1945 0.438398137020645 2868 1529587
SGTC_562 3772-2733 112 µM -0.155457099184187 0.431229018394756 no 1946 0.438230486300088 2769 2876874 YIL048W NEO1
SGTC_1378 2093-0007 380 nM -0.155993110962387 0.430986274832307 no 1947 0.438019225701455 2776 3618014
SGTC_2764 methyldopa 94.69 µM -0.15666186812561 0.430683451451923 no 1948 0.437755670374308 2811 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_205 1486-1330 71.903 µM -0.157209033870142 0.430435716813538 no 1949 0.437540054417014 2672 4118834
SGTC_916 4466-0038 42 nM -0.158112297510704 0.430026815317457 no 1950 0.437184155246283 2752 5722064 YGL116W CDC20
SGTC_2362 9071156 126 µM -0.158698330206351 0.429761562285792 no 1951 0.436953276904288 2852 653133
SGTC_2369 9071472 200 µM -0.158980982900848 0.429633637943614 no 1952 0.43684192835543 2824 17296037
SGTC_2289 7946404 165.07 µM -0.159299115548324 0.429489664748239 no 1953 0.436716608775853 2703 1246120 YPR165W RHO1
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.159335465446818 0.42947321493941 no 1954 0.436702290140238 2716 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2139 5578692 56.4705 µM -0.159984496114214 0.429179522781118 no 1955 0.436446643606234 2721 650991 YMR113W FOL3
SGTC_3002 9075603 71.4286 µM -0.160130414853519 0.429113498643383 no 1956 0.436389171359943 2692 20105405
SGTC_2979 9012552 45.46 µM -0.160384129440335 0.428998704630467 no 1957 0.436289245328291 2775 17100905
SGTC_1212 0520-0165 585 µM -0.160604866349502 0.428898836362788 no 1958 0.436202310932833 3092 5403258
SGTC_678 1218-2179 85.9 µM -0.161784990998553 0.428364988508636 no 1959 0.435737586387504 2675 6820081 YOR116C RPO31
SGTC_3209 9113616 49.47 µM -0.162316116580582 0.428124768247469 no 1960 0.435528461889544 2785 16649353
SGTC_347 4534-1311 26.2 µM -0.163460144566653 0.427607431856867 no 1961 0.435078075536307 2672 2862016
SGTC_40 0327-0103 19.753 µM -0.164094777803486 0.427320500465782 no 1962 0.434828266399302 2751 409036
SGTC_2481 5478948 45.16 µM -0.164314315540566 0.427221251655582 no 1963 0.434741856344944 2818 77792
SGTC_3240 9133527 49.47 µM -0.164403652521592 0.427180865434144 no 1964 0.434706694200849 2712 17617455
SGTC_986 1493-0483 84 µM -0.164910619738312 0.426951697203109 no 1965 0.434507166752947 2693 40079
SGTC_2344 7990960 76.95 µM -0.165406592937375 0.42672752253716 no 1966 0.434311982370012 2739 140813
SGTC_1805 st050013 60.3 µM -0.165447189192973 0.426709174503758 no 1967 0.434296006902353 2763 4037144
SGTC_3164 9100705 49.47 µM -0.166097044088171 0.426415485303896 no 1968 0.434040290161159 2858 17174235
SGTC_51 1013-0126 23.419 µM -0.166453275179734 0.426254510936507 no 1969 0.433900125567484 2788 1627850
SGTC_250 brefeldin a 552.239 µM -0.167000184467128 0.426007396470599 no 1970 0.433684951889726 2690 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_549 1661-1316 519 µM -0.167155885267208 0.425937050222054 no 1971 0.433623697216237 2766 2857282
SGTC_2331 7980721 200 µM -0.168902240039223 0.425148202078721 no 1972 0.432936768608864 2799 2981221
SGTC_1492 4158-0558 28.5 µM -0.170941019777467 0.424227641523679 no 1973 0.432135071105566 2818 3967268
SGTC_3006 9075424 71.4286 µM -0.171718024707561 0.423876912650922 no 1974 0.431829607318442 2727 7465181
SGTC_1297 1068-0111 14.1 µM -0.172392826691322 0.423572365626015 no 1975 0.431564355613786 2697 767057
SGTC_3093 9117344 49.47 µM -0.172947603228953 0.42332202184967 no 1976 0.43134630671357 2861 24824913
SGTC_730 1436-0052 41.2 µM -0.173200608708282 0.423207863003931 no 1977 0.431246872596282 2708 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_49 0717-0965 32.132 µM -0.173889381568265 0.422897113831218 no 1978 0.430976198888424 3000 5889349 YGL099W LSG1
SGTC_2818 7996756 12.99 µM -0.175070821012417 0.422364203287622 no 1979 0.430511992804743 2697 2241621
SGTC_44 0929-0055 61.211 µM -0.176158066909788 0.421873906037551 no 1980 0.430084881656084 2727 1379590
SGTC_2218 6965428 192.983 µM -0.177005628054766 0.421491779382632 no 1981 0.429751984418175 2708 675684
SGTC_312 4092-0653 6.84 µM -0.177339942131151 0.421341072727163 no 1982 0.429620689344108 2814 1148278
SGTC_1498 4478-3555 97.6 µM -0.178221302498306 0.420943816377212 no 1983 0.429274590280105 2741 3437919
SGTC_2418 pentamidine 31.67 µM -0.180600922276777 0.419871651307456 no 1984 0.42834041595744 2691 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_294 k038-0071 157 µM -0.181007159989679 0.419688675416817 no 1985 0.428180977994812 2769 24152826
SGTC_3000 9075062 71.4286 µM -0.181174553810138 0.419613283641452 no 1986 0.428115283590013 2768 17057871
SGTC_2664 lyso-paf C-16 73.48 µM -0.181224628435006 0.419590731321978 no 1987 0.428095631981151 2731 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_935 2996-0153 430 µM -0.181659616556541 0.4193948350113 no 1988 0.427924929944455 2790 23738523
SGTC_2466 5983409 37.09 µM -0.18248011809777 0.41902537767208 no 1989 0.427602977930224 2775 2879657
SGTC_2987 9018338 71.43 µM -0.183800113570469 0.418431156996301 no 1990 0.427085133519668 2693 5055682
SGTC_342 k048-0088 23.3 µM -0.184396630453992 0.41816268472457 no 1991 0.426851156502657 2692 6820570
SGTC_2013 4024628 200 µM -0.184844964677244 0.417960929594557 no 1992 0.426675319397502 2880 5230760
SGTC_910 3454-3003 490 µM -0.187755946614512 0.416651484443384 no 1993 0.42553398550922 2781 820824
SGTC_2703 st077852 53.4 µM -0.188048494220371 0.416519938813452 no 1994 0.425419318168204 2883 6281836
SGTC_1644 st010134 20.9 µM -0.188195712833351 0.416453744694511 no 1995 0.425361616554043 2771 3818134
SGTC_1201 1889-3372 45.9 µM -0.188691250799592 0.41623095265809 no 1996 0.42516740462959 2775 5392199
SGTC_2318 6029776 164 µM -0.188927195597325 0.416124882203386 no 1997 0.425074939197002 2894 818325
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.189047227775709 0.41607092333321 no 1998 0.425027900846215 2749 65057 A dermal irritant. YDR527W RBA50
SGTC_765 1319-0117 244 µM -0.189074933327716 0.416058468895283 no 1999 0.425017043713607 2739 3487746 YGL099W LSG1
SGTC_467 ro 31-8220 72.8 µM -0.190423010248326 0.415452571837626 no 2000 0.424488833989144 2820 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1286 0929-0070 131 µM -0.191256597202947 0.415078014244836 no 2001 0.424162281876804 2860 1420408
SGTC_1839 st053978 48 µM -0.191342856843885 0.415039259397317 no 2002 0.424128493208048 2748 3788398
SGTC_1192 1488-0095 21.4 µM -0.192239124031933 0.414636632258706 no 2003 0.423777450422559 2813 915875
SGTC_356 1634-0012 32.5 µM -0.193132163293688 0.414235544369363 no 2004 0.423427732077469 2776 735457
SGTC_3202 9113761 49.47 µM -0.193291342648608 0.414164062029376 no 2005 0.423365403024312 2945 4798415
SGTC_3246 9135460 32.98 µM -0.193966382603573 0.413860954872688 no 2006 0.423101102379327 2842 41446951
SGTC_1211 1056-0033 32.3 µM -0.196137723836956 0.412886325766217 no 2007 0.422251185155005 2782 6741922
SGTC_2430 5571206 200 µM -0.197944917208238 0.412075557197685 no 2008 0.421544080280532 2898 1731771
SGTC_3346 9158254 43.5805 µM -0.19958814521561 0.411338674604472 no 2009 0.420901349993977 2856 17639500
SGTC_1469 k284-2957 126 µM -0.200700085877667 0.410840217590854 no 2010 0.42046654628054 2791 23884841
SGTC_2233 sulbentine 40.3845 µM -0.200818654900721 0.410787074347566 no 2011 0.420420187784925 2772 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1068 loratadine 26.9 µM -0.201560681593613 0.410454531413606 no 2012 0.420130092911203 2809 3957 A H1 histamine antagonist.
SGTC_3213 9129884 49.47 µM -0.201824944321493 0.410336116296098 no 2013 0.420026790030939 2865 17190742
SGTC_5 0352-0601 109.883 µM -0.202119724789231 0.410204035941263 no 2014 0.419911563969148 2812 762456
SGTC_1422 4031-0024 15.5 µM -0.202309907119845 0.410118827593774 no 2015 0.419837227676287 2769 782427
SGTC_1555 citronellol 128 µM -0.202496511709482 0.410035226324125 no 2016 0.419764292589749 2812 8842 A terpine precursor.
SGTC_1419 3993-2473 62.6 µM -0.203920940015485 0.409397199025889 no 2017 0.419207640563611 2790 704026
SGTC_2057 5236571 38.335 µM -0.206131268621886 0.40840762825001 no 2018 0.418344187194277 2905 54684039 YBR257W POP4
SGTC_836 0330-0104 1.35 µM -0.206153680619294 0.408397597310319 no 2019 0.41833543407154 2770 46494820
SGTC_1947 st076332 61.6 µM -0.208055917466225 0.407546432373653 no 2020 0.417592653343479 2858 24208416
SGTC_632 0781-2353 4.65 µM -0.209386082834258 0.406951502494073 no 2021 0.417073428133995 2859 6811515 YHR007C ERG11
SGTC_2946 9065502 71.43 µM -0.210687733473989 0.406369533883942 no 2022 0.416565473516056 2777 16489101
SGTC_930 2810-3379 265 µM -0.211507640451003 0.406003059151684 no 2023 0.416245585426506 2990 1015764
SGTC_1133 3473-0247 50 µM -0.212518581409119 0.405551311143163 no 2024 0.415851241489786 2854 711311
SGTC_2413 inermin 26.06 µM -0.213986532306839 0.404895568212868 no 2025 0.415278779800573 3092 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1957 st077035 62.4 µM -0.215353420308736 0.404285210693683 no 2026 0.414745891573597 2835 705593
SGTC_564 3555-0129 330 µM -0.21575976540575 0.404103809955995 no 2027 0.414587506074501 2784 563260
SGTC_1078 idebenone 36.1 µM -0.215953776369034 0.40401720677556 no 2028 0.414511889230564 2862 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_451 chloral hydrate 100 µM -0.216194975683819 0.403909546081127 no 2029 0.41441788488407 2896 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_182 3448-4371 550.524 µM -0.216656680567914 0.403703481772541 no 2030 0.41423795499016 2764 3491403
SGTC_2173 5763948 167 µM -0.217490976389151 0.403331193572084 no 2031 0.413912869252135 2770 2867177
SGTC_937 3122-0005 46.7 µM -0.218960475940001 0.402675671329593 no 2032 0.413340418146066 2950 759535
SGTC_387 norethindrone acetate 66.7 µM -0.219242410093217 0.402549935846063 no 2033 0.413230610266773 2838 541197
SGTC_1052 3253-3998 198 µM -0.220742379400557 0.401881157341068 no 2034 0.412646515655202 2752 5450317
SGTC_740 k014-0057 261 µM -0.221099776920315 0.401721849857515 no 2035 0.412507371975893 2901 4012779
SGTC_72 0744-0168 198.391 µM -0.221139543424221 0.401704125221318 no 2036 0.412491890573433 2785 677577
SGTC_578 3460-0051 92 µM -0.221247640353218 0.401655945524542 no 2037 0.41244980830481 2801 2876744
SGTC_923 1900-2434 73.3 µM -0.221463501084433 0.401559739081957 no 2038 0.412365776466255 2766 5910570
SGTC_1431 4049-0260 9.09 µM -0.221993052412715 0.401323749925987 no 2039 0.412159645888838 2764 3854841
SGTC_1520 flindersine 88 µM -0.222348346259238 0.401165437010549 no 2040 0.412021359511121 3081 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1071 trifluoperazine 6.31 µM -0.222403756610861 0.401140748559062 no 2041 0.411999793848825 2960 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2630 antimycin a 100 µM -0.223351712327846 0.400718441792622 no 2042 0.411630891497643 2730 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2516 gossypol 71.55 µM -0.223824242313631 0.400507976720683 no 2043 0.411447032918027 2955 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2680 butyl paraben 22.24 µM -0.224883321980029 0.400036367153083 no 2044 0.411035022068275 2780 7184 An antifungal and steroid mimetic.
SGTC_857 0438-0306 1.35 µM -0.224912125396713 0.400023542986625 no 2045 0.411023818122824 2897 4686136
SGTC_976 1348-1067 47.6 µM -0.225035199614337 0.399968747776676 no 2046 0.410975945563764 2824 5310671 YGL099W LSG1
SGTC_3266 9136860 49.47 µM -0.227624829403072 0.398816248858001 no 2047 0.409968957771554 2815 4871271 YPR165W RHO1
SGTC_3159 9100096 49.47 µM -0.228091412141957 0.398608692508027 no 2048 0.409787588130942 2727 25236875
SGTC_2449 5812982 45.77 µM -0.228191703888696 0.39856408210757 no 2049 0.409748605328456 2844 776185
SGTC_1143 3454-2408 5.08 µM -0.229851008071585 0.397826205940184 no 2050 0.409103773472813 2790 X1143
SGTC_307 1501-1223 22.3 µM -0.230002060433344 0.397759052551948 no 2051 0.409045084320932 2882 2830329
SGTC_2412 st077135 33.4 µM -0.230670026250378 0.397462131155492 no 2052 0.408785580584033 3089 13258915
SGTC_2342 7990637 118.86 µM -0.230750865317242 0.397426200934776 no 2053 0.408754177435454 2928 2033102 YER133W GLC7
SGTC_2011 4012611 177 µM -0.230921751751425 0.397350250581213 no 2054 0.408687795963994 2809 2049887
SGTC_1335 1486-0900 202 µM -0.231751868029761 0.396981361416191 no 2055 0.408365371507562 2785 X1335
SGTC_266 formosanin C 406 nM -0.232389111304345 0.396698244149297 no 2056 0.408117902690083 2931 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2881 9058953 51.95 µM -0.233631346272584 0.39614649514181 no 2057 0.40763559515383 2781 17122249
SGTC_324 1315-0088 19.6 µM -0.233686962329818 0.396121797662588 no 2058 0.407614005048456 2888 6787421
SGTC_2241 6772625 37.8075 µM -0.233781345221659 0.396079885909813 no 2059 0.407577366333561 2781 2285411
SGTC_1229 0139-0193 12.2 µM -0.233979407629298 0.395991938042778 no 2060 0.407500482654267 2939 3090752
SGTC_2303 7774051 200 µM -0.236016731319593 0.39508759047587 no 2061 0.406709843585637 3007 2953184
SGTC_3063 1327-0034 4 µM -0.23622984763181 0.394993022830854 no 2062 0.406627159888957 2896 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_141 0443-0274 32.331 µM -0.237540652364703 0.394411506171857 no 2063 0.406118692736789 2950 1627241
SGTC_2941 9056145 11.23 µM -0.238107005249876 0.39416032586087 no 2064 0.405899050786165 2803 2119517
SGTC_29 0299-0004 12.984 µM -0.240155331538575 0.393252251161833 no 2065 0.405104920339512 2826 16871 A napthoquinone isolated from Swertia calycina.
SGTC_3033 9090887 49.47 µM -0.240240005495678 0.393214725521055 no 2066 0.405072100864528 2833 19325384
SGTC_2726 cimetidine 79.27 µM -0.240824323557568 0.392955795634822 no 2067 0.404845638435841 2823 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1674 st016616 23.6 µM -0.241426284076148 0.392689097337968 no 2068 0.404612371695779 2781 625830
SGTC_1381 2324-0066 62.1 µM -0.244243151319233 0.391441757123807 no 2069 0.40352125445117 2955 10885928
SGTC_215 1287-0124 461.5 µM -0.244487685061947 0.39133352729368 no 2070 0.403426569266597 2897 5560863
SGTC_2399 5884133 200 µM -0.244889178926434 0.391155845679367 no 2071 0.403271120298566 2866 722445
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.247115677014681 0.39017091935702 no 2072 0.402409350705434 2888 4213774
SGTC_595 3909-8003 73.7 µM -0.247424102716073 0.39003453783405 no 2073 0.402290011340581 2965 699517
SGTC_2563 tomatine 8.54 µM -0.248173745378142 0.38970311281261 no 2074 0.401999989586611 2923 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_899 1083-0020 478 µM -0.248339617689043 0.389629789719829 no 2075 0.40193582419097 3023 767123
SGTC_2428 5615643 7.78 µM -0.248409203430924 0.389599030831929 no 2076 0.401908906701782 2973 2253075
SGTC_3135 9127742 49.47 µM -0.249372018323664 0.38917351017467 no 2077 0.40153651385514 2905 3643468
SGTC_2219 9098279 200 µM -0.249822625606145 0.388974407741631 no 2078 0.401362260860233 2884 902349
SGTC_2463 5473429 200 µM -0.25116723191705 0.388380462135975 no 2079 0.400842408896943 2910 5399405
SGTC_1029 k015-0030 64.7 µM -0.251610543458993 0.388184697672354 no 2080 0.400671054132969 2964 2208316
SGTC_2627 acetyl isogambogic acid 100 µM -0.251936258481779 0.388040881424246 no 2081 0.400545166541727 2947 6857789 A caspase activator and apoptosis inducer.
SGTC_1231 0242-0792 125 µM -0.251963586815218 0.38802881556667 no 2082 0.40053460471653 2819 3707635
SGTC_3329 9141233 27.5565 µM -0.253032137144326 0.387557119871229 no 2083 0.40012168961219 3021 4909101 YNL103W MET4
SGTC_3156 9099931 49.47 µM -0.253139244424287 0.387509848088862 no 2084 0.400080306775112 2835 18111053
SGTC_1962 st076595 64.5 µM -0.253215668160918 0.387476119503288 no 2085 0.400050779766484 2842 279619
SGTC_1369 1866-0067 208 µM -0.253314887442185 0.387432331678551 no 2086 0.400012446343479 2975 3531355
SGTC_1776 st049249 45.9 µM -0.253349724371788 0.387416957653963 no 2087 0.399998987305384 2896 1822314
SGTC_1855 st056195 39.6 µM -0.25404390628306 0.387110642302772 no 2088 0.399730819088887 3039 4028379
SGTC_2063 5246145 200 µM -0.254160277072084 0.387059299294844 no 2089 0.399685868714935 2977 711240
SGTC_478 N-arachidonylglycine 10 µM -0.254763911934965 0.386793006201885 no 2090 0.399452724908704 2890 5283389
SGTC_2952 9073731 13.78 µM -0.255888126430854 0.386297201896376 no 2091 0.399018611602416 2891 16457353
SGTC_1363 1636-0063 10.4 µM -0.255905764396461 0.386289424626853 no 2092 0.399011801728817 2867 6072185
SGTC_839 0122-0028 230 µM -0.256237033709411 0.386143363508395 no 2093 0.398883907081054 2869 759448
SGTC_58 0957-0393 9 µM -0.256518805657083 0.386019139145599 no 2094 0.398775130649151 2922 6997992
SGTC_3189 9110682 49.47 µM -0.256613185928422 0.385977532473329 no 2095 0.398738697448212 2962 17122418
SGTC_1453 4237-0541 195 µM -0.25750937533318 0.385582521054438 no 2096 0.398392789406472 2994 739892
SGTC_896 0964-0007 44.5 µM -0.258004716132869 0.385364241670708 no 2097 0.398201633736939 2854 6756758
SGTC_1685 st024049 53.0905 µM -0.258011641942132 0.385361189965775 no 2098 0.398198961189103 2953 1941139
SGTC_203 k066-0004 30.888 µM -0.258529393846117 0.38513307413326 no 2099 0.39799918337813 2873 6795412
SGTC_2026 5148700 152 µM -0.258692683762268 0.385061138620381 no 2100 0.39793618248653 2843 79838
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.2595540705733 0.384681729994596 no 2101 0.397603884326897 3069 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_26 0302-0163 425.158 µM -0.260877630907334 0.384098966531375 no 2102 0.397093437812239 2871 3100915
SGTC_1271 0832-2808 169 µM -0.261178609771882 0.383966482080091 no 2103 0.396977386357474 3017 3663794
SGTC_305 1682-2595 20.8 µM -0.262306002654254 0.383470348506352 no 2104 0.396542767280494 2932 226033
SGTC_2345 9052315 157.45 µM -0.262604274957321 0.383339119261102 no 2105 0.396427802370496 2959 6469265
SGTC_844 0330-0132 15.3 µM -0.264232465151411 0.382623009566042 no 2106 0.395800398094135 2999 2828079
SGTC_763 3453-1109 128 µM -0.264311582221757 0.382588222540861 no 2107 0.395769918108061 3019 1560353
SGTC_948 3448-0295 75.3 µM -0.264752483572005 0.382394379757587 no 2108 0.395600071790151 2848 678569
SGTC_1578 josamycin 24.2 µM -0.265145688243303 0.382221531729396 no 2109 0.39544861615873 2884 5282165 A P450 substrate.
SGTC_2204 7233102 200 µM -0.265435992807119 0.382093932404122 no 2110 0.395336805997915 2886 2172480
SGTC_2179 6298986 200 µM -0.265567854860671 0.382035978504497 no 2111 0.395286022464451 3022 738374
SGTC_3030 9087619 49.47 µM -0.265647471575723 0.382000987919635 no 2112 0.395255360841371 2925 25236973
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.265775840787685 0.381944573231051 no 2113 0.395205925246716 3062 94937 An inhibitor of serotonin biosynthesis.
SGTC_3296 9122258 64.045 µM -0.266711421201775 0.381533487514563 no 2114 0.394845679763165 2964 4730474
SGTC_3085 9117376 49.47 µM -0.266725458791781 0.381527320538456 no 2115 0.394840275269134 2953 16480349
SGTC_594 1487-1584 10.8 µM -0.267108643672524 0.381358991866789 no 2116 0.394692756311323 2902 5013332
SGTC_2095 5432005 200 µM -0.269311934709235 0.380391548066618 no 2117 0.393844824393652 2887 783734
SGTC_3191 9110352 49.47 µM -0.269841973592478 0.380158924454498 no 2118 0.393640914956999 2870 17122424
SGTC_1112 tnp00069 1.16933 µM -0.271263983142908 0.379535046849344 no 2119 0.393094002767644 2986 145826
SGTC_2681 menadione 3.18 µM -0.271303554777084 0.379517690080369 no 2120 0.393078786325275 2968 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_680 0417-1641 114 µM -0.271353489161343 0.379495788385425 no 2121 0.393059585337736 2865 2835990
SGTC_1611 st001856 99.4 µM -0.273626140461382 0.378499392258332 no 2122 0.392185971608567 2912 647478
SGTC_640 3381-0960 37.1 µM -0.273631821400644 0.378496902578833 no 2123 0.392183788517836 2953 1745025
SGTC_2730 imipramine 71.33 µM -0.273949771929295 0.378357568362434 no 2124 0.392061610815298 2898 3696 A tricyclic antidepressant.
SGTC_1568 digitonin 820 nM -0.274396049087616 0.378162024750907 no 2125 0.391890139455068 3049 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2134 5324836 1.464 µM -0.275426830002144 0.37771049064126 no 2126 0.39149416676695 2924 699272
SGTC_2728 chlorpromazine 9.18 µM -0.275653640322518 0.37761115866588 no 2127 0.39140705305237 2865 2726 A thorazine and dopamine antagonist.
SGTC_3022 9087993 49.47 µM -0.276305651362891 0.377325654392405 no 2128 0.391156657829051 2956 17173644
SGTC_1771 st048882 4.1505 µM -0.27778622462663 0.376677586321208 no 2129 0.390588233164224 2882 4580403
SGTC_1848 st056003 16.4 µM -0.278803259227508 0.376232616894639 no 2130 0.390197906549102 2928 146492
SGTC_397 arbidol 50 µM -0.279279336414264 0.376024381740616 no 2131 0.390015231400113 3045 131410 A RNA synthesis inhibitor.
SGTC_2826 7992541 19.48 µM -0.280016386354435 0.375702068866954 no 2132 0.389732466549957 2852 2985066
SGTC_553 k007-0256 45.7 µM -0.28012085266902 0.375656392626487 no 2133 0.389692393384427 2944 6287000
SGTC_1163 k060-0048 49.9 µM -0.280132332601943 0.37565137331401 no 2134 0.389687989766052 2906 6809982
SGTC_1485 3909-9022 254 µM -0.280227664713138 0.37560969255469 no 2135 0.389651421612027 2922 714516
SGTC_279 1273-0055 2.93 µM -0.28122979921989 0.375171630871308 no 2136 0.38926707505852 2960 2847562
SGTC_1953 st076800 12.1 µM -0.281265489471268 0.375156032605497 no 2137 0.389253388846162 2932 297591
SGTC_1316 1272-0050 65.9 µM -0.281584679152202 0.375016541253743 no 2138 0.389130994648896 2900 7340392
SGTC_1798 st045719 60.953 µM -0.282261780097451 0.37472069069287 no 2139 0.388871394784097 2902 3980186
SGTC_2821 7996764 71.43 µM -0.283468035198105 0.374193815772095 no 2140 0.388409040699599 3136 2987135
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.285204753884324 0.373435654727819 no 2141 0.387743639239461 2886 364106
SGTC_1856 st057054 55.7 µM -0.285831600540598 0.373162126190206 no 2142 0.387503551825858 3148 1266018
SGTC_1414 3917-0015 5.4 µM -0.286154641549264 0.373021190131951 no 2143 0.387379841257996 3000 6618702
SGTC_1321 1326-2144 215 µM -0.286586219201379 0.372832928314686 no 2144 0.387214583751818 3034 3513030
SGTC_2870 9038528 12.99 µM -0.288601335702672 0.371954301401562 no 2145 0.386443236617803 3041 6463316
SGTC_1468 k284-1086 134 µM -0.288669401761971 0.371924634989037 no 2146 0.386417190076902 2949 15996457
SGTC_2061 5245884 80.95 µM -0.289002034719214 0.371779668731913 no 2147 0.386289910243123 2911 573863
SGTC_1322 1348-1070 12 µM -0.289193394370883 0.371696279661727 no 2148 0.386216693262368 3004 6758089
SGTC_1979 st071809 45.3 µM -0.289665827588411 0.371490432544071 no 2149 0.38603595080929 3041 4976333
SGTC_1684 st024538 14.6195 µM -0.289967395828042 0.37135905338856 no 2150 0.38592059043092 2914 6732859
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.290223187348986 0.371247628751417 no 2151 0.385822749151633 2895 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.291095117734083 0.37086789070332 no 2152 0.385489286905672 3049 6708760
SGTC_2371 9071574 200 µM -0.291911636920957 0.370512399006788 no 2153 0.385177092920191 3034 45596039
SGTC_2378 9074213 121.43 µM -0.29258493648632 0.370219344633298 no 2154 0.384919714547617 2921 657714
SGTC_960 1222-0186 7.7 µM -0.293609535043852 0.369773531554613 no 2155 0.384528144431424 3044 3126296
SGTC_829 1635-0120 117 µM -0.293868085793359 0.369661061162729 no 2156 0.384429352867314 3060 285054
SGTC_16 erodoxin 22.806 µM -0.295627447050781 0.368896030008768 no 2157 0.383757305163137 3038 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3217 9129673 49.47 µM -0.296316708799842 0.368596456514399 no 2158 0.383494113424924 3116 17248312
SGTC_725 1497-0963 19 µM -0.297338898533534 0.368152329744198 no 2159 0.383103893512772 3049 3549977
SGTC_2684 capsaicin 100 µM -0.298074914455587 0.36783265043277 no 2160 0.382822993579417 3021 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1888 azatryptophan 97.5 µM -0.299198194461272 0.367344944310327 no 2161 0.382394413422747 3036 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1926 methyl fluorone black 53.6 µM -0.301216415093919 0.366469210447701 no 2162 0.381624736668736 2942 72721 Reacts with homocysteine.
SGTC_598 3937-0236 20.2 µM -0.302089795453513 0.366090453745497 no 2163 0.381291805658035 3008 1379313
SGTC_3281 9140613 49.47 µM -0.302815066594077 0.365776026321881 no 2164 0.381015400353758 2972 16013766
SGTC_84 0443-0269 128.823 µM -0.304311645184848 0.365127498447525 no 2165 0.380445237020788 2993 6150058
SGTC_2294 7971431 200 µM -0.30450170638177 0.365045164817821 no 2166 0.380372846463791 3074 5741572
SGTC_1254 0550-0035 264 µM -0.30538842044435 0.364661126671112 no 2167 0.38003516999068 3083 15121435
SGTC_999 SEC7.066 22.7 µM -0.305579724258405 0.364578290289152 no 2168 0.379962330080628 2943 740511 YDR170C SEC7
SGTC_1165 k072-0275 30.3 µM -0.305924059278068 0.36442920586619 no 2169 0.379831233483979 3054 6153523 YGL055W OLE1
SGTC_1111 tnp00062 510.699 nM -0.305939882836109 0.364422355339092 no 2170 0.379825209407861 3090 676306
SGTC_1877 wortmannin 25 µM -0.308321816775993 0.363391634576514 no 2171 0.378918733375828 3088 312145 A covalent inhibitor of PI 3-kinase.
SGTC_392 N-ethylmaleimide 8.33 µM -0.308896967749263 0.363142900600082 no 2172 0.378699951738105 2994 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_3121 9125696 49.47 µM -0.309872430362773 0.362721176919612 no 2173 0.378328984475112 2967 1235365
SGTC_2798 7813637 45.45 µM -0.310055751003941 0.36264194011114 no 2174 0.378259280360169 3084 956368
SGTC_22 0964-0034 14.468 µM -0.310295686879336 0.362538241348548 no 2175 0.378168055387921 2983 138402
SGTC_36 0335-0881 14.2 µM -0.312580781102061 0.361551144420139 no 2176 0.377299590704183 2957 23828853
SGTC_3336 9143619 71.43 µM -0.313479880013036 0.361163010814641 no 2177 0.37695805217561 3077 45595730
SGTC_1689 st020265 53.493 µM -0.313742121534675 0.361049830204859 no 2178 0.376858453242602 3088 5758320 YPR016C TIF6
SGTC_1959 st077091 55.8 µM -0.313875260178513 0.360992373658393 no 2179 0.376807890522947 2906 821356 YKL052C ASK1
SGTC_2108 5365811 200 µM -0.315372781458552 0.360346328323372 no 2180 0.376239315207376 3063 780283
SGTC_1745 st081495 74 µM -0.315889528731237 0.360123490886801 no 2181 0.376043180076588 2970 13842402 YBL026W LSM2
SGTC_981 1488-1094 54.9 µM -0.316525983438425 0.359849097207875 no 2182 0.375801653132789 2912 3449522
SGTC_56 0957-0365 83.25 µM -0.316785786492601 0.359737109489225 no 2183 0.3757030749616 3087 6752360
SGTC_2587 piperic acid 92.2 µM -0.318389250498783 0.359046205558897 no 2184 0.375094845614558 3027 5370536
SGTC_3134 9127454 49.47 µM -0.318540437002247 0.358981085738535 no 2185 0.375037513224557 3068 24262820
SGTC_968 1309-0633 340 µM -0.318952387469139 0.358803669135946 no 2186 0.374881308897521 3069 3761976
SGTC_630 4356-0227 183 µM -0.319044727153075 0.358763904957078 no 2187 0.374846298138287 2986 779312
SGTC_2751 anetholtrithion 17.25 µM -0.319296459525364 0.358655509382911 no 2188 0.374750858590551 3097 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.322033071227363 0.357477864839144 no 2189 0.373713820364184 2973 4620898
SGTC_1772 st048439 82.2 µM -0.324665879402691 0.356346169303849 no 2190 0.372716980569784 3073 2927068 YDL195W SEC31
SGTC_1966 st070145 16.1 µM -0.326755588100239 0.355448820689738 no 2191 0.371926376325576 2925 3748532
SGTC_606 k015-0008 38.6 µM -0.326855253986056 0.355406042804326 no 2192 0.371888682962815 3128 1970475
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.327165421849968 0.355272926409189 no 2193 0.371771386191521 2975 229346 A bile salt which induces apoptosis.
SGTC_115 0527-0192 112.043 µM -0.328323394107786 0.354776109416139 no 2194 0.371333578865217 3080 4233931
SGTC_1176 0848-0131 83.3 µM -0.329942383020925 0.354081911638856 no 2195 0.370721748999951 3064 6769040
SGTC_128 0906-2981 13.371 µM -0.331675324047277 0.353339390001665 no 2196 0.370067217726831 3164 6740226
SGTC_906 1165-0455 526 µM -0.331801281313184 0.353285442196756 no 2197 0.370019658348264 2987 3252859
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.332048582280979 0.353179531164368 no 2198 0.369926287379282 2994 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_815 1582-0027 36.9 µM -0.333182449855086 0.352694077936313 no 2199 0.369498282507505 3081 3128206
SGTC_1266 0828-0227 32.9 µM -0.335603511463034 0.351658329803293 no 2200 0.368584937839331 3105 3913820
SGTC_1990 st072050 59.8 µM -0.337397021717203 0.350891761665819 no 2201 0.367908814747755 2978 17233948
SGTC_1718 roemerine 11.9335 µM -0.338317495665283 0.350498575196171 no 2202 0.36756197031104 3135 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2620 irigenin 100 µM -0.33866976356182 0.350348144001923 no 2203 0.36742926055616 3184 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1391 3442-0225 151 µM -0.341182590225096 0.349275757821274 no 2204 0.36648306440985 2992 5227075
SGTC_2657 nystatin 74.44 µM -0.342370951500632 0.348769025120961 no 2205 0.366035873188249 3067 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3061 glucosamine 200 µM -0.344220714556956 0.347980798892367 no 2206 0.365340152577261 3105 91431 and experimental redox chemotherapeutic
SGTC_1985 st071382 65.5 µM -0.345021481026991 0.347639777419121 no 2207 0.365039110830326 3033 6123237
SGTC_3241 9133421 49.47 µM -0.345524015159311 0.347425826725914 no 2208 0.364850229604093 3065 17018221
SGTC_894 0960-0238 55.9 µM -0.347062785659906 0.346771007523651 no 2209 0.364272075285235 3126 6741907 YDL195W SEC31
SGTC_1388 3346-4487 254 µM -0.347977821976147 0.346381833305727 no 2210 0.363928419679522 3092 3345614
SGTC_116 0155-0182 31.788 µM -0.348274884423317 0.346255524475971 no 2211 0.363816876936693 3037 771486
SGTC_1332 1480-0653 17.5 µM -0.349651110979329 0.345670586067302 no 2212 0.36330027405243 3166 5749438
SGTC_3199 9111318 49.47 µM -0.35001413572951 0.345516350760811 no 2213 0.363164044541457 3125 8548020
SGTC_306 1672-3436 11.6 µM -0.350751065319592 0.345203336501544 no 2214 0.362887555879277 3124 6797378
SGTC_2766 oltipraz 83.91 µM -0.351489558784025 0.344889764177401 no 2215 0.362610552151922 3163 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_711 k292-0785 179 µM -0.351507640361599 0.344882087878666 no 2216 0.362603770779928 2999 4146315
SGTC_2196 6573537 42.6665 µM -0.351610428550519 0.344838451702325 no 2217 0.362565221591718 3140 2903087
SGTC_136 0097-0015 404.482 µM -0.353199030256131 0.344164312995419 no 2218 0.361969617419468 3101 4861337
SGTC_717 1532-0246 73.2 µM -0.357640737933387 0.342282062947005 no 2219 0.360306093798235 3090 9561992
SGTC_1367 1812-0510 76.9 µM -0.35983815116299 0.341352314354805 no 2220 0.359484085541433 3092 1142582 YDR527W RBA50
SGTC_1842 st055362 61.2 µM -0.360144752658165 0.341222664403567 no 2221 0.359369443638371 3035 676032
SGTC_368 fentichlor 4.58 µM -0.360842729397125 0.340927586864298 no 2222 0.359108509154174 3083 7329 A pesticide.
SGTC_2317 5986382 200 µM -0.361639274045369 0.340590957495141 no 2223 0.358810805930526 3113 877883
SGTC_2816 7982706 58.44 µM -0.361732316608328 0.340551644861261 no 2224 0.358776037485828 3139 2981853
SGTC_2771 fluoxetine 41.05 µM -0.361988365446634 0.340443467251492 no 2225 0.358680362372852 3224 3386 A selective serotonin reuptake inhibitor.
SGTC_2763 lisinopril 49.32 µM -0.362342235487242 0.34029398294749 no 2226 0.358548150023313 3077 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1788 fluconazole 20 µM -0.362617922315401 0.340177542741339 no 2227 0.35844516010519 3143 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2180 6301957 200 µM -0.363883073371859 0.3396433839998 no 2228 0.357972662464787 3180 845462
SGTC_1742 st038235 28.8875 µM -0.364097388926942 0.339552929801201 no 2229 0.357892643272752 3155 564103 YBR002C RER2
SGTC_2607 solasodine 47.35 µM -0.364139691244234 0.339535076742455 no 2230 0.357876849556142 3058 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.364402296769825 0.339424256074989 no 2231 0.357778810317851 3110 1241132 A phosphatase inhibitor.
SGTC_1683 st010134 710 nM -0.364784734782934 0.339262890416089 no 2232 0.357636050470615 3019 3818134
SGTC_1251 0490-5699 265 µM -0.364888297276882 0.339219198391651 no 2233 0.357597395171863 3227 3883818
SGTC_1357 1503-1303 39.5 µM -0.36592279888757 0.338782870808351 no 2234 0.357211341705012 3069 292895
SGTC_909 3448-9333 149 µM -0.366068436173461 0.338721461899476 no 2235 0.3571570047668 3027 3344074
SGTC_2374 9071832 200 µM -0.367265114351874 0.338217037221124 no 2236 0.356710636658863 3067 17381698
SGTC_2268 7933382 153.85 µM -0.367923570451825 0.33793960804512 no 2237 0.35646511221668 3046 935025 YOR257W CDC31
SGTC_1360 1598-0022 39.8 µM -0.368927946111563 0.33751660113581 no 2238 0.356090716219167 3162 761525
SGTC_1299 1079-1439 3.74 µM -0.369590687290843 0.337237590738797 no 2239 0.355843745504546 3068 323161
SGTC_1727 st034309 9.9045 µM -0.369608299058694 0.337230177501277 no 2240 0.355837183298193 3280 870305
SGTC_2988 9073640 71.4286 µM -0.371613795476881 0.336386427404594 no 2241 0.355090208126468 3259 9102229
SGTC_2750 bromebric acid 70.15 µM -0.371998655922895 0.336224603398893 no 2242 0.354946925037364 3216 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.372156402676619 0.336158283675983 no 2243 0.354888202033155 3194 5282362
SGTC_2710 st078562 53.7235 µM -0.372619167227006 0.335963758122325 no 2244 0.354715952616688 3017 17250908
SGTC_235 0330-0087 5 mM -0.374887312142286 0.335010967427652 no 2245 0.353872137766487 3092 46494818 YHR062C RPP1
SGTC_2332 7982454 138.89 µM -0.374959319233509 0.334980736399892 no 2246 0.353845360792901 3159 2981748
SGTC_2719 novobiocin 32.65 µM -0.375331629992162 0.334824444730292 no 2247 0.353706922695362 3179 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2393 9031399 185.94 µM -0.376967257052078 0.334138166961506 no 2248 0.353098969011105 3207 1526623 YDL150W RPC53
SGTC_1445 4239-0156 97.7 µM -0.378386179292657 0.333543263144872 no 2249 0.35257186683091 3244 4008346
SGTC_625 k213-0058 121 µM -0.378547399751246 0.333475695558546 no 2250 0.352511994429962 3135 3655420
SGTC_2665 lovastatin 100 µM -0.378742135007117 0.333394089104862 no 2251 0.352439680519532 3103 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1269 0831-0796 3.05 µM -0.378815459431701 0.333363363552106 no 2252 0.352412453263125 3194 927758
SGTC_1466 k213-0079 57.5 µM -0.379457642038579 0.333094313899266 no 2253 0.352174026572161 3077 3657981
SGTC_2282 7944268 200 µM -0.379745282523111 0.332973831511888 no 2254 0.352067251530009 3274 2970414
SGTC_2806 7952793 58.44 µM -0.380989074589549 0.332453049763053 no 2255 0.351605677742896 3210 2972490
SGTC_928 2764-0428 58.7 µM -0.381258930103122 0.332340102597326 no 2256 0.351505562656074 3177 662578
SGTC_2391 6285546 200 µM -0.38205095442423 0.332008691286164 no 2257 0.351211784974313 3040 846083
SGTC_1860 st056228 74.6 µM -0.382927887407797 0.331641904409139 no 2258 0.350886616661195 3183 688679
SGTC_3274 9138298 49.47 µM -0.383263106880647 0.331501737783722 no 2259 0.350762345514778 3030 17015756
SGTC_521 r062-0005 13.8 µM -0.383686486943727 0.331324741946388 no 2260 0.350605414663531 3059 2832033
SGTC_1168 k815-0004 80.5 µM -0.38394461340108 0.331216849564543 no 2261 0.350509749531471 3031 642433
SGTC_1657 st012939 43.4 µM -0.384633349403448 0.330929038445015 no 2262 0.350254541128902 3206 24207257
SGTC_1154 4088-0362 150 µM -0.38488014754252 0.33082592998168 no 2263 0.350163107500295 3049 6618304
SGTC_2796 7949634 45.45 µM -0.384985202048506 0.330782043719788 no 2264 0.350124189603976 3038 2971588
SGTC_3338 9144300 39.5675 µM -0.385646878814525 0.330505683352762 no 2265 0.349879104774446 3127 4901274
SGTC_360 0957-0399 1.01 µM -0.386391904193307 0.330194621633966 no 2266 0.349603222496628 3211 6752301 YPR165W RHO1
SGTC_3186 9110464 49.47 µM -0.387688533222746 0.329653535183898 no 2267 0.349123271281699 3209 17018021
SGTC_1189 1431-2119 7.28 µM -0.388104086157363 0.329480199285725 no 2268 0.348969504093573 3133 3107275
SGTC_2678 equilin 100 µM -0.388539827793468 0.329298481598948 no 2269 0.348808293107606 3207 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1324 1418-0026 34.4 µM -0.388841397664605 0.329172741274839 no 2270 0.348696737520946 3176 1372513
SGTC_728 3030-5151 22.5 µM -0.389137078615885 0.329049475110405 no 2271 0.348587373041107 3074 3125388
SGTC_1694 st024011 44.9 µM -0.389587468350073 0.328861748262802 no 2272 0.34842081010152 3193 2787533
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.390144587550743 0.328629595253857 no 2273 0.348214816951114 3103 6857784
SGTC_546 peri-Naphthalide 147 µM -0.391043621605424 0.328255104923578 no 2274 0.347882496248177 3120 223824 A penicillin ester.
SGTC_686 1319-0111 510 µM -0.391268496917434 0.328161460648432 no 2275 0.34779939115303 3239 4562600
SGTC_104 0074-0074 590.992 µM -0.392746255402294 0.327546350175459 no 2276 0.3472534516443 3055 3943124
SGTC_230 MPP+ 141.667 µM -0.393243939222929 0.327339296692883 no 2277 0.347069659795289 3143 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_304 1310-0298 97 µM -0.393382751749751 0.327281555406166 no 2278 0.347018403519388 3151 1550234
SGTC_1306 1185-0270 9.02 µM -0.393484221876122 0.327239349901626 no 2279 0.346980937628383 3204 1548076
SGTC_2094 5332512 191.667 µM -0.393643733758253 0.327173006962999 no 2280 0.346922043960471 3234 755774
SGTC_2448 5185112 27.17 µM -0.393843869355771 0.327089775848404 no 2281 0.346848156768358 3216 5718189
SGTC_1137 ixabepilone 100 µM -0.394127612526005 0.326971789288368 no 2282 0.346743412841381 3071 154225 A novel microtubule stabilizer.
SGTC_2228 7354201 200 µM -0.39478763046718 0.326697406440512 no 2283 0.346499812225973 3120 753451
SGTC_1929 genistein trimethyl ether 50.5 µM -0.395189821592028 0.326530253367734 no 2284 0.346351401912688 3281 136420
SGTC_1129 3453-1384 223 µM -0.395581059735253 0.326367685832463 no 2285 0.346207055930109 3280 1084452
SGTC_1108 betulinic acid 729.144 nM -0.395619326380113 0.326351787020616 no 2286 0.346192938780598 3142 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_3286 9117135 37.221 µM -0.395806692829 0.326273945609925 no 2287 0.346123819522452 3113 3438150
SGTC_2275 7947463 200 µM -0.396027511539089 0.326182216167988 no 2288 0.346042366345623 3232 1225414
SGTC_540 1187-0821 17.3 µM -0.396340531220013 0.326052203897165 no 2289 0.345926915294438 3112 847520
SGTC_2000 st075254 36.4 µM -0.399898456761889 0.324575913843573 no 2290 0.344615654491617 3137 17234175
SGTC_2160 5660466 132.927 µM -0.401977793471518 0.323714407168549 no 2291 0.34385018461907 3201 2859134
SGTC_2927 9011802 47.9 µM -0.402259238756882 0.323597871730715 no 2292 0.343746624751712 3206 43912568
SGTC_2203 7227154 166.4 µM -0.403460195970547 0.323100797015761 no 2293 0.343304855524049 3158 896304
SGTC_374 0880-0231 82.3 µM -0.404530994826458 0.322657860891291 no 2294 0.34291114518869 3162 6833587
SGTC_1202 1988-0068 29.6 µM -0.404790984350891 0.322550354107494 no 2295 0.342815578191216 3114 2850480
SGTC_1723 st034307 2.5525 µM -0.405996250885008 0.322052165132034 no 2296 0.342372677560399 3172 867466
SGTC_2723 salbutamol 83.58 µM -0.406368354470863 0.321898423091686 no 2297 0.342235983990772 3207 9884233 β2-adrenoceptor agonist
SGTC_634 1611-4317 11.2 µM -0.40688783972302 0.32168383835395 no 2298 0.342045183816128 3250 2843522
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.40739413814433 0.321474757948465 no 2299 0.34185926579567 3079 15053
SGTC_1904 st060225 78 µM -0.409050967684239 0.320790951130759 no 2300 0.34125112910034 3205 66595
SGTC_2984 9022109 38.96 µM -0.411031532360981 0.319974329610331 no 2301 0.340524706680755 3243 6459207
SGTC_3317 9138495 8.753 µM -0.411155478009863 0.31992325358568 no 2302 0.340479266094081 3160 17020139
SGTC_3179 9107801 49.47 µM -0.411163288374101 0.319920035173492 no 2303 0.340476402759028 3124 4818259
SGTC_222 nsc-310342 10.666 µM -0.411351237521168 0.319842591167438 no 2304 0.340407502038929 3226 432556
SGTC_813 k007-0158 173 µM -0.411513912150235 0.319775567806471 no 2305 0.340347871064204 3175 6523916
SGTC_3166 9102297 49.47 µM -0.411965734478146 0.319589443953558 no 2306 0.340182269342047 3173 25237072
SGTC_1793 st048256 72.231 µM -0.413411565921763 0.318994153116594 no 2307 0.339652551091685 3131 672022
SGTC_980 1473-0395 201 µM -0.415048914645165 0.318320572400371 no 2308 0.339053047713857 3098 768876
SGTC_2086 5274770 176.623 µM -0.415444424438636 0.318157955522478 no 2309 0.338908295687947 3190 689278
SGTC_1470 k295-0292 231 µM -0.415705347087245 0.318050694362585 no 2310 0.338812814024857 3240 5045612
SGTC_2121 5257820 149.641 µM -0.415940641421223 0.31795398168054 no 2311 0.33872671963085 3268 791256
SGTC_1973 st070275 50.2 µM -0.416369376971382 0.317777791064422 no 2312 0.338569866599593 3201 17118334
SGTC_3303 9125618 40.5795 µM -0.416689627884559 0.317646209563349 no 2313 0.338452720971861 3190 22695467
SGTC_588 3970-1144 52.9 µM -0.416712678348424 0.317636739706958 no 2314 0.338444289870302 3214 1888707
SGTC_1044 1222-0021 1.78 µM -0.41721931348116 0.317428628181444 no 2315 0.33825899985974 3194 4306703
SGTC_568 1193-0097 7.48 µM -0.417453600947934 0.31733240895661 no 2316 0.338173327910593 3198 3646150
SGTC_907 3448-6986 75.5 µM -0.418268945310741 0.316997652466372 no 2317 0.337875246101141 3315 590582
SGTC_3320 9137005 35.139 µM -0.419313482560399 0.316569014895026 no 2318 0.337493522178431 3183 4908713
SGTC_1144 3486-0183 12.5 µM -0.419402389456743 0.316532542316452 no 2319 0.337461039056119 3161 6744069
SGTC_2292 7671323 168.05 µM -0.41958033177086 0.31645954979425 no 2320 0.337396029492956 3277 937504
SGTC_277 nystatin 15.5 µM -0.419607212942323 0.316448523670824 no 2321 0.33738620912987 3087 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1124 fisetin 1.16336 µM -0.41973711409813 0.316395243092219 no 2322 0.337338754555467 3182 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1833 st055984 71 µM -0.420325347174662 0.316154019675601 no 2323 0.33712389779073 3162 676288
SGTC_365 0121-0052 13.6 µM -0.42325403056697 0.314954187229222 no 2324 0.336054964881193 3261 3101739
SGTC_3221 9128209 49.47 µM -0.423502054115768 0.314852665543882 no 2325 0.335964500094487 3163 16460723
SGTC_586 0957-0265 8.15 µM -0.42398597167829 0.314654627348567 no 2326 0.335788022040011 3221 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_124 0136-0217 7.121 µM -0.427808786310647 0.313092058004625 no 2327 0.33439516975861 3338 3976905
SGTC_1444 4112-3581 28 µM -0.427945175927421 0.313036370714051 no 2328 0.334345517805373 3178 2877249
SGTC_135 0933-0004 26.348 µM -0.427964985278967 0.313028282996161 no 2329 0.334338306551687 3276 21230617 YGL099W LSG1
SGTC_102 gallobenzophenone 83.616 µM -0.428333810878364 0.312877716137416 no 2330 0.334204053104479 3324 70837
SGTC_2492 derrusnin 100 µM -0.428702425355216 0.312727266647472 no 2331 0.334069897695949 3106 1715307 Part of coumarin class of compounds.
SGTC_2476 5806916 10.51 µM -0.431018969632842 0.311782487129568 no 2332 0.333227288727236 3135 2870194
SGTC_2673 kobusone 100 µM -0.43124801853695 0.311689138936791 no 2333 0.333144021174029 3198 6710676 An epoxy ketone and protein crosslinker.
SGTC_1665 st014639 11.4 µM -0.431851487850926 0.311443254775088 no 2334 0.332924677661303 3242 981133 YIL048W NEO1
SGTC_2853 9015042 58.44 µM -0.432210793375861 0.311296895313974 no 2335 0.332794107713699 3054 6457456
SGTC_2031 5180455 200 µM -0.432235716186782 0.311286744365622 no 2336 0.33278505163256 3156 29949
SGTC_837 0091-0265 12.5 µM -0.432897078438612 0.311017426955519 no 2337 0.332544771290463 3164 759367
SGTC_1481 3346-2004 36 µM -0.433531827814122 0.310759041881758 no 2338 0.332314224391327 3257 2770522
SGTC_2221 6807166 181.081 µM -0.433845977625176 0.310631196589811 no 2339 0.332200145708713 3211 674925
SGTC_3208 9114115 49.47 µM -0.434035538768627 0.310554064519985 no 2340 0.332131317009067 3224 650895
SGTC_2258 7960471 200 µM -0.434066851286918 0.310541324317033 no 2341 0.332119948135755 3219 2974708
SGTC_520 3584-0023 682 µM -0.435290951076909 0.310043449975013 no 2342 0.331675626133399 3190 1340790
SGTC_484 loperamide 105 µM -0.435517771034895 0.309951234389128 no 2343 0.331593321323258 3180 3955 An opioid-receptor agonist.
SGTC_287 k060-0039 29.6 µM -0.435651622961954 0.309896821356676 no 2344 0.331544755084241 3294 5861974
SGTC_670 4204-0025 119 µM -0.436597007112398 0.309512625614956 no 2345 0.331201816772838 3254 719039
SGTC_1975 st070967 30.8 µM -0.4381917614507 0.308865003292853 no 2346 0.330623640125113 3327 261391
SGTC_2937 9044753 11.33 µM -0.438519839727774 0.308731845810844 no 2347 0.330504745715059 3145 6465530 YGL099W LSG1
SGTC_558 k064-0027 21.3 µM -0.438872006577091 0.308588939453155 no 2348 0.330377140725514 3255 5088526
SGTC_529 4076-0302 30.3 µM -0.439097234748577 0.30849755894407 no 2349 0.33029554134254 3178 5816522
SGTC_3044 9093193 49.47 µM -0.439276323607251 0.308424906733543 no 2350 0.330230663831143 3251 25236277
SGTC_665 3914-0008 307 µM -0.439803631678109 0.308211033606566 no 2351 0.330039668551487 3154 1069549
SGTC_2115 tiliquinol 12.7705 µM -0.439829998140572 0.308200341228994 no 2352 0.330030119566232 3224 71208 A bioactive hydroxyquinoline.
SGTC_2154 5570129 200 µM -0.44090504368924 0.307764517262428 no 2353 0.329640871064436 3267 673366
SGTC_571 k831-0106 44.2 µM -0.441669503780633 0.307454769668072 no 2354 0.329364190390374 3300 4783639
SGTC_966 1300-0360 30.2 µM -0.441862109728684 0.307376750308228 no 2355 0.329294495337812 3171 70588
SGTC_660 4031-1742 102 µM -0.442507190661331 0.307115509297565 no 2356 0.329061114035564 3219 6738706
SGTC_1977 st070720 65.3 µM -0.442827667362707 0.306985760945025 no 2357 0.328945194786944 3276 682188
SGTC_2597 laccaic acid a 100 µM -0.4428723261848 0.306967682270989 no 2358 0.328929042602859 3272 5491415 A textile dye.
SGTC_1092 toremifene 6.32 µM -0.446044547459961 0.305684714379457 no 2359 0.327782533756198 3205 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_400 oxethazaine 37.5 µM -0.44720740471618 0.305215006019836 no 2360 0.327362657748528 3254 4621 A local anesthetic.
SGTC_2656 pseudo-anisatin 100 µM -0.447313573964988 0.305172137453234 no 2361 0.327324333799514 3207 6708809 A neurotoxin.
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.448076101459592 0.30486432591201 no 2362 0.327049137494369 3293 688662
SGTC_1838 st055369 84.5 µM -0.448155514267029 0.304832277062405 no 2363 0.327020482801322 3240 676036
SGTC_2732 terfenadine 20 µM -0.448578434867074 0.304661623035407 no 2364 0.326867896637741 3237 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_176 1486-1328 72.834 µM -0.448905742797378 0.304529579150284 no 2365 0.326749826581795 3255 22310231
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.449049804314387 0.304471469343289 no 2366 0.326697864650742 3241 5355888
SGTC_1002 4049-0206 172 µM -0.449952948821001 0.30410728224175 no 2367 0.326372183686141 3186 4662749
SGTC_2652 actinonin 100 µM -0.450921852821572 0.30371679404745 no 2368 0.326022936463431 3170 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1564 D-Arginine 115 µM -0.451956564996292 0.303300031077803 no 2369 0.325650136745356 3226 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1515 3460-0031 42.1 µM -0.452069667409596 0.303254491014787 no 2370 0.325609397281179 3248 2876596
SGTC_2985 9022375 71.43 µM -0.453372620342498 0.30273008481566 no 2371 0.325140224244817 3359 4939335
SGTC_3330 9141424 71.43 µM -0.453543311775102 0.302661415855541 no 2372 0.325078781433733 3306 27261020
SGTC_2462 5162487 171.77 µM -0.453684258412659 0.302604718452306 no 2373 0.325028049270395 3298 2259986
SGTC_1765 st044815 90.4 µM -0.45429692085332 0.302358323282412 no 2374 0.324807565995071 3269 645695
SGTC_2749 bexarotene 57.39 µM -0.454627404447086 0.302225449684718 no 2375 0.32468865793953 3249 82146 An retinoic acid receptor inhibitor.
SGTC_3231 9132313 49.47 µM -0.455757109622532 0.301771440621416 no 2376 0.324282324785239 3259 4905967
SGTC_2486 5283202 22.39 µM -0.455964841777919 0.301687990026356 no 2377 0.324207630290871 3212 1377751
SGTC_1426 4048-4480 71.7 µM -0.456368137403965 0.301526006902509 no 2378 0.32406263701258 3308 14224343
SGTC_1222 0366-0074 1.18 µM -0.457603303269068 0.301030147897031 no 2379 0.323618734937726 3334 286520
SGTC_869 0564-0080 44.1 µM -0.458407948205213 0.30070731995383 no 2380 0.323329691212254 3242 6843321
SGTC_921 1561-0023 372 µM -0.459046107893567 0.30045139795147 no 2381 0.323100527933414 3186 24050882
SGTC_1921 5740136 50 µM -0.459940765238202 0.300092778116704 no 2382 0.322779369320869 3348 1774243
SGTC_1797 st048695 56.8 µM -0.461001523711826 0.299667828361503 no 2383 0.322398755957796 3302 592262 YIL048W NEO1
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.462038227835144 0.299252778608371 no 2384 0.322026953390111 3225 689007
SGTC_575 k072-0246 11.9 µM -0.462872236767136 0.298919068335526 no 2385 0.32172797445039 3274 6796779
SGTC_2279 7948423 32.93 µM -0.46370286477897 0.298586878983702 no 2386 0.321430322211245 3372 1247112
SGTC_3023 9089636 49.47 µM -0.465105573992932 0.298026281269137 no 2387 0.320927927262206 3364 17249241
SGTC_1150 3909-7983 10.9 µM -0.465254403335373 0.297966829251251 no 2388 0.320874641692786 3230 23965914
SGTC_2727 riluzole 51.77 µM -0.465433602510157 0.297895252741952 no 2389 0.320810487667267 3284 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_375 3970-0961 9.27 µM -0.465787545048275 0.297753902521393 no 2390 0.320683790536936 3245 2898222
SGTC_1559 coumarin 343 70.1 µM -0.467865271656648 0.29692476089375 no 2391 0.31994046991391 3357 108770 A hepatotoxic, DNA x-linker.
SGTC_1939 st074455 53.6 µM -0.468443232863124 0.296694306509502 no 2392 0.319733828704074 3399 1644229
SGTC_2629 bisabolol 100 µM -0.471002433168067 0.295674844964114 no 2393 0.318819498671749 3363 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2091 4-phenylthiadiazole 200 µM -0.474126964821547 0.294432370118306 no 2394 0.317704685474742 3203 270010
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.474477332630615 0.294293196233302 no 2395 0.317579779196199 3266 6312947
SGTC_319 1348-1596 45.5 µM -0.474532540597258 0.294271269172519 no 2396 0.317560099425002 3386 5380505
SGTC_164 4100-3994 89.624 µM -0.474828503187767 0.294153733974381 no 2397 0.31745460757192 3379 4615967
SGTC_1770 st043884 66.3 µM -0.475075417526389 0.294055693838941 no 2398 0.317366609645413 3273 670149
SGTC_246 cycloheximide 667 µM -0.476504706496801 0.293488475463659 no 2399 0.316857427559357 3195 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2312 7706453 155.7 µM -0.476548929480439 0.293470933501602 no 2400 0.316841678711536 3227 976098
SGTC_376 3970-0862 59.1 µM -0.476581009931228 0.293458208430548 no 2401 0.31683025431385 3329 3135186
SGTC_2157 5649910 96.377 µM -0.478600163092894 0.292657803469356 no 2402 0.316111551149673 3217 2858091
SGTC_860 0443-0016 25.1 µM -0.480345788666876 0.29196664497362 no 2403 0.315490767601674 3308 5337942
SGTC_2588 indole-3-carbinol 100 µM -0.480685665069446 0.291832163635197 no 2404 0.315369960410794 3357 3712 Induces cell cycle arrest.
SGTC_1090 efavirenz 20.7 µM -0.483030549916788 0.29090513348738 no 2405 0.314537022379603 3301 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2895 9054447 58.44 µM -0.484106144310162 0.290480367387615 no 2406 0.314155270461525 3253 2697450
SGTC_422 cantharidin 155 µM -0.484560929853186 0.290300854073426 no 2407 0.313993916907275 3211 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3255 9139072 49.47 µM -0.484862961486076 0.290181664622821 no 2408 0.313886778622052 3335 17646060
SGTC_635 k038-0028 24.7 µM -0.484974355247161 0.290137711567881 no 2409 0.313847268387731 3277 4035102
SGTC_692 k241-0027 77.8 µM -0.485364114860854 0.289983947212104 no 2410 0.313709041417963 3398 3600480
SGTC_2885 9057732 51.95 µM -0.486019755052579 0.289725376338899 no 2411 0.313476579765562 3383 6471414
SGTC_1905 st060207 84.5 µM -0.486881122936972 0.289385835277522 no 2412 0.313171288552719 3213 1948547
SGTC_1459 k035-0031 35.7 µM -0.487071881443153 0.28931066581734 no 2413 0.313103696076973 3207 3877128 YMR208W ERG12
SGTC_1359 1582-0056 520 nM -0.488508018393675 0.288745042788269 no 2414 0.312595023776785 3347 3661189
SGTC_2135 5326629 150.42 µM -0.489168277201532 0.288485174466704 no 2415 0.312361283171311 3253 5020077
SGTC_1910 st062352 60.4 µM -0.491696906496486 0.287490963283997 no 2416 0.311466812732087 3227 2245730
SGTC_1632 st005650 90 µM -0.493455087024213 0.286800634912097 no 2417 0.31084553353403 3314 2759605
SGTC_2860 9025725 38.96 µM -0.494336393012876 0.286454896622751 no 2418 0.310534313605899 3223 40546248
SGTC_2248 tofa 1.1 µM -0.495780340495781 0.285888860697108 no 2419 0.31002469839242 3197 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_513 4245-1575 41.7 µM -0.495866693381799 0.285855026715504 no 2420 0.309994233248343 3290 719745
SGTC_377 3970-0964 33.1 µM -0.496449860797446 0.285626585363401 no 2421 0.309788526984896 3328 16481235
SGTC_1497 4476-2978 41.3 µM -0.496898461405691 0.285450916353638 no 2422 0.309630328286568 3354 1528379
SGTC_2964 9083345 53.42 µM -0.497046906373092 0.285392797623302 no 2423 0.309577987033303 3281 17741579
SGTC_895 0964-0006 13.7 µM -0.497225283861399 0.285322967257051 no 2424 0.309515096770782 3393 6738897
SGTC_768 0384-0033 77.3 µM -0.497448759728664 0.285235493480395 no 2425 0.309436314117203 3261 3965305 YMR134W ERG29
SGTC_989 1501-0895 10.3 µM -0.497631568768906 0.285163947171477 no 2426 0.309371874380634 3393 2830112
SGTC_2205 7238770 200 µM -0.497709905853857 0.285133290861156 no 2427 0.309344262545154 3376 279867
SGTC_2724 maprotiline 69.64 µM -0.498468116881643 0.284836654974413 no 2428 0.309077068043227 3397 4011 A tricyclic antidepressant.
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.499416017651252 0.284466013758281 no 2429 0.30874316867034 3310 6708561
SGTC_2928 9011484 9.79 µM -0.499976828979056 0.284246837954397 no 2430 0.308545696486302 3363 2994751
SGTC_3276 9139060 49.47 µM -0.501347080553061 0.283711657271248 no 2431 0.30806343819513 3350 4870619
SGTC_559 1550-0661 158 µM -0.501839400577328 0.283519489200585 no 2432 0.307890247628301 3354 5830875
SGTC_752 1896-0090 130 µM -0.503237115809463 0.282974256941137 no 2433 0.307398786297349 3362 772567
SGTC_91 0417-1751 58.384 µM -0.503848945680745 0.28273574781594 no 2434 0.307183764819737 3388 6795624
SGTC_1382 3002-2117 298 µM -0.504009544769101 0.282673157616261 no 2435 0.307127334858282 3432 1497314
SGTC_3108 9121785 49.47 µM -0.50401667652699 0.282670378314365 no 2436 0.307124829066886 3367 17140271
SGTC_142 0335-0849 62.6745 µM -0.504966820917842 0.282300217077008 no 2437 0.306791069978687 3425 3889043 YPR107C YTH1
SGTC_2210 7115885 190.385 µM -0.50548351161554 0.282099020497861 no 2438 0.306609638209436 3345 2927039
SGTC_1375 2910-0797 186 µM -0.506564338288366 0.281678375805959 no 2439 0.306230267903194 3291 742508
SGTC_126 0417-1624 672.48 µM -0.507071092717204 0.281481257290202 no 2440 0.306052468514402 3447 41912 YDL195W SEC31
SGTC_204 PMA1.184 62.41 µM -0.507171855446514 0.281442070303194 no 2441 0.306017120440297 3313 2252213 YGL008C PMA1
SGTC_3092 9117248 49.47 µM -0.507215980333704 0.28142491080504 no 2442 0.306001641775822 3370 17141857
SGTC_561 1550-0330 72.9 µM -0.507265008663416 0.281405845024734 no 2443 0.305984443428462 3289 6812934
SGTC_1130 3454-2858 15.9 µM -0.509161600103645 0.280668791178925 no 2444 0.305319478334182 3308 715628 YIL048W NEO1
SGTC_1450 4112-4260 37.6 µM -0.510374784053468 0.280197813575339 no 2445 0.304894459636423 3408 1633175
SGTC_423 5-fluorouracil 457 µM -0.51105872538706 0.279932465390916 no 2446 0.304654968167716 3202 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2078 5212016 200 µM -0.514231615446355 0.278703078057669 no 2447 0.303545033134063 3348 1899708
SGTC_2274 7947094 46.08 µM -0.514437790344783 0.278623283314773 no 2448 0.303472971902046 3399 2971028
SGTC_2187 6125751 200 µM -0.515398450329181 0.278251631092011 no 2449 0.303137307574578 3356 874498
SGTC_2452 5863136 48.41 µM -0.515700168581257 0.278134954716986 no 2450 0.303031918438183 3313 2184096
SGTC_106 0092-0003 11.579 µM -0.516090620033935 0.277984000076743 no 2451 0.302895559443622 3323 1072148
SGTC_2916 7875993 68.79 µM -0.516313364347698 0.277897901553208 no 2452 0.302817781821572 3432 1299250
SGTC_2224 6650123 117.647 µM -0.517128243713342 0.27758303293231 no 2453 0.302533319349495 3344 2908370
SGTC_310 1273-0058 1.06 µM -0.517288911214201 0.277520971740012 no 2454 0.302477246814119 3404 2734232
SGTC_2931 9014674 55.67 µM -0.518272642200337 0.277141132944534 no 2455 0.302134028941546 3263 2996810
SGTC_703 3875-0075 71.8 µM -0.518938692836589 0.276884101577905 no 2456 0.301901747154923 3359 2850814
SGTC_2315 7733312 200 µM -0.518963839444803 0.276874399697537 no 2457 0.301892978974709 3281 726316
SGTC_1289 0976-0073 69.1 µM -0.519140838201753 0.276806116042561 no 2458 0.301831265857167 3405 3391136
SGTC_1018 4259-0013 28.1 µM -0.520071216178752 0.276447324875282 no 2459 0.30150696970144 3394 6801262
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.521552594428557 0.275876516912418 no 2460 0.300990938586936 3397 279621
SGTC_1902 st060212 70.5 µM -0.521963804505208 0.275718171266073 no 2461 0.300847766133518 3446 688944
SGTC_1666 st014829 29 µM -0.522502291138228 0.275510882509259 no 2462 0.300660325822487 3361 3858230
SGTC_3152 9099253 49.47 µM -0.523212327830892 0.275237673313833 no 2463 0.300413251740928 3378 25236131
SGTC_2080 5212524 12.4 µM -0.523442010945781 0.27514932399019 no 2464 0.300333347702128 3409 260183
SGTC_2377 9073351 62.6 µM -0.523857206150958 0.274989651504011 no 2465 0.3001889305807 3295 7337946 YHR072W ERG7
SGTC_1394 3474-0001 65.7 µM -0.524193766029398 0.274860253478655 no 2466 0.300071888189581 3323 5017666 YIL048W NEO1
SGTC_2576 guaiol 23.12 µM -0.52440925604022 0.274777419252404 no 2467 0.299996960014947 3335 227829
SGTC_2193 5925765 200 µM -0.525417185328998 0.274390135347053 no 2468 0.299646604713118 3411 877370
SGTC_3043 9092303 49.47 µM -0.526832737088544 0.273846683050754 no 2469 0.299154873457341 3345 25236084
SGTC_3077 9117319 49.47 µM -0.527286668377585 0.273672524546086 no 2470 0.298997265394491 3411 17154678
SGTC_278 4092-0821 23.9 µM -0.527672804513185 0.273524419955218 no 2471 0.298863225963697 3396 877900
SGTC_394 menadione 8.33 µM -0.528674519544942 0.273140391811763 no 2472 0.298515627987982 3407 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1371 2421-0008 32.7 µM -0.530164904516634 0.27256951689879 no 2473 0.297998800820227 3307 2827552
SGTC_1282 0886-0010 32.4 µM -0.530643137066989 0.272386460998247 no 2474 0.297833048542898 3466 2836211 YNL267W PIK1
SGTC_396 dithiazanine 1.25 µM -0.530885357760697 0.272293768054567 no 2475 0.297749112476904 3328 10578 An antihelmenthic.
SGTC_2326 6164455 177.58 µM -0.531813938231206 0.271938564428178 no 2476 0.297427434085795 3360 2888790
SGTC_496 calpeptin 138 µM -0.532869506363468 0.271535065181093 no 2477 0.297061957581338 3375 73364 A calpain inhibitor.
SGTC_487 nimodipine 119 µM -0.533188557492332 0.271413164080167 no 2478 0.296951530781357 3330 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1857 st056007 79.3 µM -0.53335573861694 0.271349299428718 no 2479 0.296893675214557 3426 619834
SGTC_908 3448-7491 47.7 µM -0.533979331820713 0.271111147454304 no 2480 0.296677916833603 3378 1203031
SGTC_898 1000-0849 28.3 µM -0.534022714535321 0.271094583354081 no 2481 0.296662909424772 3389 6751807
SGTC_2515 chrysin 20.77 µM -0.535410471138506 0.270564985790694 no 2482 0.296183025495847 3395 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_514 4466-0038 2.65 nM -0.536303249979273 0.270224555719611 no 2483 0.295874492421714 3347 5722064
SGTC_2580 diallyl disulphide 81.36 µM -0.539015821373075 0.269191527080584 no 2484 0.294937968862263 3336 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2858 9025781 8.96 µM -0.541167756018637 0.268373417375437 no 2485 0.294195979941345 3461 4894980 YPL153C RAD53
SGTC_439 amiodarone 34.4 µM -0.54127050742475 0.268334385258633 no 2486 0.294160572750516 3290 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1038 k292-0204 154 µM -0.541275465854412 0.268332501775066 no 2487 0.294158864170998 3383 4454212
SGTC_1915 st067105 30.6 µM -0.54154016214803 0.268231965257004 no 2488 0.294067661575039 3443 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_652 0437-0092 114 µM -0.542689624320106 0.267795598360683 no 2489 0.293671759623016 3415 3091274
SGTC_1341 1486-1360 280 µM -0.543233022989327 0.267589434118965 no 2490 0.293484686194315 3328 3976547
SGTC_52 0329-0193 875 nM -0.543750425833814 0.267393207025831 no 2491 0.293306613546811 3517 3739292
SGTC_1246 0422-0085 105 µM -0.546105181907455 0.26650107424503 no 2492 0.292496818998313 3475 264295
SGTC_464 bw-b 70c 158 µM -0.546770872517899 0.266249141143538 no 2493 0.292268078261445 3457 5353454
SGTC_2403 6032726 181.2 µM -0.546798013603849 0.266238872056364 no 2494 0.29225875396495 3378 2881040
SGTC_1034 k072-0165 12.7 µM -0.546841347262547 0.266222476771383 no 2495 0.292243867011002 3466 5835461
SGTC_3015 9080845 49.47 µM -0.547209537620218 0.266083192613608 no 2496 0.292117392205011 3459 5296973
SGTC_2473 5854593 8.94 µM -0.548259683091583 0.265686131854413 no 2497 0.291756803203186 3348 2872951
SGTC_870 0573-2213 57.6 µM -0.548459140699891 0.265610750752776 no 2498 0.291688338785026 3454 3916321
SGTC_3147 9097027 49.47 µM -0.549007251152133 0.265403659001628 no 2499 0.291500236813086 3369 25236841
SGTC_2475 5812728 15.03 µM -0.550464805954361 0.264853352209073 no 2500 0.291000304821593 3426 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_249 wiskostatin 11.211 µM -0.550607173385035 0.264799631813883 no 2501 0.290951495184055 3454 2775510 A n-wasp and actin depolymerizer.
SGTC_2189 6047310 154.431 µM -0.552357975801009 0.264139443825797 no 2502 0.290351558364986 3401 711535
SGTC_617 3770-0098 35 µM -0.552459279378584 0.264101270214581 no 2503 0.290316863019301 3386 5962639
SGTC_3141 9094609 49.47 µM -0.553108400762036 0.263856732473313 no 2504 0.290094592277071 3290 25236309 YDL196W YDL196W
SGTC_990 3985-0011 41.3 µM -0.553219191551236 0.26381500677775 no 2505 0.290056663503747 3368 5399565 YGL099W LSG1
SGTC_469 w7 172 µM -0.553436862559736 0.263733037973628 no 2506 0.289982151495253 3443 45115570 A P450 inhibitor.
SGTC_1934 st074720 32.6 µM -0.554023282756094 0.26351227320905 no 2507 0.289781455851275 3418 17250992
SGTC_1461 k072-0203 53.8 µM -0.554093016913216 0.263486027243081 no 2508 0.289757594465203 3379 5418714
SGTC_1777 st045864 34.765 µM -0.554583836049762 0.263301334543075 no 2509 0.289589673803364 3465 4691462
SGTC_1207 2099-0101 141 µM -0.555761379889834 0.26285850063022 no 2510 0.289186995023754 3436 5837381
SGTC_1681 tripelennamine 100 µM -0.555938856288317 0.26279179087534 no 2511 0.289126327142263 3456 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2855 9016525 58.44 µM -0.556486355508991 0.262586051667974 no 2512 0.288939209735227 3438 43811474
SGTC_1471 k673-0312 37 µM -0.556518346059427 0.26257403281131 no 2513 0.288928278168937 3431 24099884
SGTC_2683 piperine 63.03 µM -0.557104586747985 0.262353831923325 no 2514 0.288727986952648 3372 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1714 st033236 13.627 µM -0.558763804172081 0.261731117724111 no 2515 0.288161464086537 3527 2916566
SGTC_2908 7930301 100 µM -0.559015900943136 0.261636570707927 no 2516 0.288075434130875 3366 2223178
SGTC_1692 fluoroquinolonic acid 71 µM -0.559211442409668 0.261563246410073 no 2517 0.288008712454802 3472 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1442 4112-3290 3 µM -0.560310271632326 0.261151402810741 no 2518 0.287633911209605 3433 704353
SGTC_849 0386-0493 241 µM -0.561114189623906 0.260850303834317 no 2519 0.287359847770547 3375 726119
SGTC_982 1491-0518 27.5 µM -0.562321360448441 0.260398506419182 no 2520 0.286948543715157 3368 3091256
SGTC_209 4077-0173 175.592 µM -0.563155253730817 0.260086647919107 no 2521 0.286664584766351 3408 15993494
SGTC_2689 tacrolimus 100 µM -0.563424979393168 0.25998581743948 no 2522 0.286572765792408 3419 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1244 0416-0015 52.5 µM -0.563773367845766 0.259855610600833 no 2523 0.286454189384006 3393 96201
SGTC_3138 9097216 49.47 µM -0.564055472976759 0.259750201172653 no 2524 0.286358190023105 3476 25237486
SGTC_1288 0973-0013 65.5 µM -0.564842395728623 0.259456281796404 no 2525 0.286090483789009 3479 4315430
SGTC_3120 9124077 49.47 µM -0.565416879000478 0.259241818102787 no 2526 0.285895123266873 3474 18774327 YGL155W CDC43
SGTC_1958 st076513 41.9 µM -0.565547972849064 0.259192891537386 no 2527 0.285850551985001 3367 732122 YGL099W LSG1
SGTC_2035 5154463 94.595 µM -0.566327549346333 0.258902038284418 no 2528 0.285585567972263 3480 2769623
SGTC_2529 gangaleoidin 93.61 µM -0.566939335404947 0.258673904498959 no 2529 0.285377699118276 3422 4565183
SGTC_2686 alizarin 95.37 µM -0.568015541772953 0.258272842014844 no 2530 0.285012207397711 3386 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2176 5809774 33.9695 µM -0.568788189425222 0.257985103563223 no 2531 0.284749945336974 3441 2870539
SGTC_1258 0671-0043 57.1 µM -0.568994844287463 0.257908172292862 no 2532 0.284679819397831 3427 4298767
SGTC_317 4495-0002 170 µM -0.57070119444634 0.257273405621785 no 2533 0.284101104494906 3446 15991618
SGTC_3122 9126309 49.47 µM -0.570961826926562 0.257176521206252 no 2534 0.284012759596745 3491 17591206
SGTC_2127 5253358 187.912 µM -0.571536219954419 0.256963070169751 no 2535 0.28381810773985 3391 20612
SGTC_3344 9148862 3.898 µM -0.571915409005791 0.256822209692978 no 2536 0.283689642140868 3529 4905352
SGTC_271 rotenone 740 µM -0.573068327376299 0.256394172607516 no 2537 0.283299215660802 3511 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2313 7726885 200 µM -0.573532756963094 0.256221851721454 no 2538 0.28314201317978 3455 726423
SGTC_448 monastrol 171 µM -0.576690210690466 0.255051920019219 no 2539 0.282074373292289 3435 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_86 0417-1630 471.922 µM -0.577216077631742 0.25485734230272 no 2540 0.281896748714184 3499 3634867
SGTC_6 0844-0013 19.835 µM -0.577310918837057 0.254822258075399 no 2541 0.281864719486105 3553 1584900
SGTC_3148 9097893 49.47 µM -0.577707444104652 0.254675600457387 no 2542 0.281730826241453 3373 17174100
SGTC_2291 7917025 104.35 µM -0.57781022487908 0.25463759349051 no 2543 0.281696125635569 3401 2964612
SGTC_2445 5742597 35.57 µM -0.577916957725332 0.254598128244326 no 2544 0.281660092921507 3375 1774255
SGTC_2295 7971645 200 µM -0.578892812539263 0.254237447439438 no 2545 0.281330750121395 3418 2978226 YKL099C UTP11
SGTC_1386 3228-0095 33.8 µM -0.579347407304331 0.254069518467558 no 2546 0.281177391699866 3486 870181
SGTC_2015 5119600 184 µM -0.579447343791486 0.254032609366468 no 2547 0.28114368334711 3505 2828786
SGTC_655 k060-0012 42 µM -0.584974653669915 0.251995620805203 no 2548 0.279282379864502 3427 5994525
SGTC_1355 1499-0035 1.68 µM -0.585013076563326 0.251981490980593 no 2549 0.279269462066892 3485 1548538
SGTC_1430 4049-0248 69.1 µM -0.585906276618929 0.251653139041607 no 2550 0.278969249580862 3530 22774488
SGTC_1303 1160-0052 261 µM -0.58777680057847 0.250966243013225 no 2551 0.278341058908765 3507 3562476
SGTC_667 1498-1044 59 µM -0.588016986523233 0.250878113583175 no 2552 0.278260445622357 3460 6739982
SGTC_171 k064-0041 9.68 µM -0.58850877866834 0.250697715506586 no 2553 0.278095421607381 3416 53325
SGTC_3333 9141820 12.094 µM -0.588735198777946 0.250614683697901 no 2554 0.27801946093723 3421 1939433
SGTC_612 0302-0167 22.4 µM -0.588944644579861 0.250537889606609 no 2555 0.277949203916479 3498 235821
SGTC_3323 9138564 53.9225 µM -0.589257926924595 0.250423046732069 no 2556 0.277844131883274 3536 43912313 YNL103W MET4
SGTC_3184 9108758 49.47 µM -0.590156193565342 0.250093915377563 no 2557 0.277542969021338 3500 902885
SGTC_615 k087-0205 167 µM -0.590308177370951 0.250038250125692 no 2558 0.277492029023714 3442 9642773
SGTC_416 estradiol valerate 100 µM -0.590609495092013 0.249927909603454 no 2559 0.27739105069714 3505 13791 A steroid.
SGTC_2954 9074818 52.69 µM -0.591049718726744 0.24976674914121 no 2560 0.277243554188113 3505 16648742
SGTC_1821 st053465 65.6 µM -0.591266423467917 0.249687436470457 no 2561 0.277170961564011 3466 675086
SGTC_1187 1391-0724 117 µM -0.591429468065813 0.249627771917964 no 2562 0.277116350361292 3513 6997986
SGTC_807 1315-0151 48 µM -0.592275642584611 0.249318244431499 no 2563 0.276833011846226 3567 4011080
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.593874772132832 0.248733846425981 no 2564 0.276297936792306 3436 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_443 clozapine 122 µM -0.59429345938355 0.248580958769222 no 2565 0.276157926250744 3452 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2972 9093619 59.92 µM -0.594359189687399 0.248556961267153 no 2566 0.276135948960872 3402 25236256
SGTC_697 0508-1955 564 µM -0.594512807149688 0.248500881821694 no 2567 0.276084589462673 3519 6243113
SGTC_1670 st016595 4.04 µM -0.595629058782682 0.248093586622533 no 2568 0.275711529814791 3504 597879
SGTC_835 0312-0010 67.2 µM -0.597075032236399 0.247566513206177 no 2569 0.275228643345067 3471 1626196
SGTC_200 k038-0079 37.545 µM -0.59723739847442 0.247507366285021 no 2570 0.275174446743462 3436 3436683
SGTC_913 3487-1245 167 µM -0.597862838873248 0.24727960086286 no 2571 0.274965728667216 3450 4016153
SGTC_3355 9151058 44.0485 µM -0.601406540261882 0.245991216919473 no 2572 0.273784621799695 3535 17015728
SGTC_3220 9131269 49.47 µM -0.602241196095922 0.245688285902584 no 2573 0.273506798602736 3550 17722206
SGTC_1085 doxorubicin 7.67 µM -0.602650879857138 0.245539668100636 no 2574 0.273370482510579 3540 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2701 st077767 14.721 µM -0.605666105500456 0.244447345333685 no 2575 0.272368247865745 3513 5721188
SGTC_178 4092-0806 87.505 µM -0.606564548383383 0.244122374370076 no 2576 0.272069966659825 3536 2169044
SGTC_2875 9039966 71.43 µM -0.606591579687394 0.244112600633408 no 2577 0.272060994839456 3506 6463691
SGTC_662 k832-1615 104 µM -0.60671873162158 0.244066629007584 no 2578 0.272018794471893 3501 5878478
SGTC_726 3448-4391 34.2 µM -0.606759598871643 0.244051854495091 no 2579 0.272005231759795 3617 1356692
SGTC_1545 lovastatin 49.4 µM -0.608372529074846 0.243469126119006 no 2580 0.271470213464494 3524 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2882 9058044 58.44 µM -0.610396376943434 0.242739003739217 no 2581 0.270799633794409 3500 18076804
SGTC_657 3534-0529 86.7 µM -0.610408921395195 0.242734481907655 no 2582 0.270795479908554 3539 1049549
SGTC_954 1189-0853 2.85 µM -0.611049167966004 0.242503756205745 no 2583 0.270583515189318 3531 2828194
SGTC_681 1642-0006 26.6 µM -0.613148840458529 0.241747931343871 no 2584 0.269888964315426 3550 4446530
SGTC_2352 9027995 87.8 µM -0.614860563551052 0.241132704958071 no 2585 0.269323404365439 3490 2997347
SGTC_2912 7964298 10.93 µM -0.615255800752483 0.24099077011726 no 2586 0.269192900966275 3549 2975850
SGTC_941 3237-0776 460 µM -0.616029809448882 0.240712945148258 no 2587 0.268937422907903 3576 760008
SGTC_358 0075-0058 9.45 µM -0.617961747947018 0.240020250624521 no 2588 0.268300277017915 3593 1069125
SGTC_1690 st023502 41.2 µM -0.619015902174533 0.239642743543639 no 2589 0.267952941484041 3554 24207482
SGTC_207 4185-0010 4.486 µM -0.621908442578512 0.238608551780731 no 2590 0.267001036687446 3606 3761753
SGTC_2014 4013930 200 µM -0.622217806309276 0.238498087411578 no 2591 0.266899329506893 3545 64556
SGTC_1328 1441-0025 69.2 µM -0.622399121882753 0.238433358155812 no 2592 0.266839728851727 3516 4562601
SGTC_320 4092-0846 5.34 µM -0.623049438330961 0.238201275773686 no 2593 0.26662601717976 3506 1359356
SGTC_18 0111-0177 500 nM -0.623254027697272 0.238128288325047 no 2594 0.266558801449348 3621 721752
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.623552654274654 0.238021775015993 no 2595 0.266460706145973 3553 442882
SGTC_3169 9102970 49.47 µM -0.623755419367281 0.237949468207033 no 2596 0.266394110618732 3610 17027839
SGTC_1556 plumbagin 1.48 µM -0.628469366850406 0.236271855360855 no 2597 0.264848253998733 3521 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3311 9131146 2.8755 µM -0.628515766959858 0.23625537479375 no 2598 0.264833060587968 3519 4900406 YPR165W RHO1
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.631393502003277 0.235234488016313 no 2599 0.263891631847137 3561 61125 An anti-inflammatory.
SGTC_2132 5317594 122.667 µM -0.632037242430919 0.235006452639806 no 2600 0.263681270893334 3551 794577
SGTC_140 0062-0056 502.533 µM -0.632312209071789 0.234909087075002 no 2601 0.263591443605072 3547 3758964
SGTC_321 4534-3890 65.3 µM -0.632445966776742 0.234861731592335 no 2602 0.263547752706831 3564 699746
SGTC_85 0868-0259 160.055 µM -0.632733347091223 0.234760005518566 no 2603 0.263453894697257 3486 83173
SGTC_1981 st071826 47 µM -0.634173211378666 0.234250693355221 no 2604 0.262983894069722 3531 11838600
SGTC_3279 9140807 49.47 µM -0.635713659194229 0.233706480481012 no 2605 0.26248153594197 3595 45595718
SGTC_476 mead acid 10 µM -0.636111449622073 0.233566062130296 no 2606 0.262351891663835 3591 5312531 An omega 9 fatty acid.
SGTC_3193 9111931 49.47 µM -0.636114471502573 0.233564995598259 no 2607 0.262350906925244 3589 17087244
SGTC_518 1021-0119 62.6 µM -0.636656511448951 0.233373733592164 no 2608 0.262174303282834 3496 1097762
SGTC_2674 ligustilide 100 µM -0.636970795068909 0.233262876566584 no 2609 0.262071933510563 3556 5319022 A signalling regulator.
SGTC_3247 9135149 49.47 µM -0.638997512768429 0.232548696303076 no 2610 0.261412274967835 3553 8934436 YOR116C RPO31
SGTC_951 1171-0579 82.7 µM -0.639701888888424 0.232300771329005 no 2611 0.261183213609167 3583 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_972 1319-0219 195 µM -0.643131563828562 0.231095704454651 no 2612 0.260069367536131 3551 23903702
SGTC_1233 0325-0408 14.2 µM -0.643518806364225 0.230959860616749 no 2613 0.259943757893941 3596 12874
SGTC_1274 0865-0114 173 µM -0.643746274124866 0.230880086210583 no 2614 0.259869988896168 3565 870624
SGTC_1730 st033808 45.1 µM -0.644122073959637 0.230748324506072 no 2615 0.259748138686544 3577 1045166
SGTC_2355 9061122 103.12 µM -0.645832453049183 0.230149167918028 no 2616 0.259193934118431 3561 5302957
SGTC_1876 myriocin 605 nM -0.646153029810928 0.230036964786142 no 2617 0.259090127481611 3618 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_855 0428-0020 25 µM -0.647503885604104 0.229564496340832 no 2618 0.258652940277883 3566 6812414
SGTC_531 3788-1495 174 µM -0.647598847354766 0.22953130346769 no 2619 0.258622221495658 3572 2896655
SGTC_1308 1187-1617 41.4 µM -0.649384649010957 0.228907596449868 no 2620 0.258044891905674 3594 2882570
SGTC_2394 5221648 200 µM -0.6502864350456 0.228593001474772 no 2621 0.257753608815967 3638 788586
SGTC_2056 5235370 200 µM -0.650294399819398 0.228590223984609 no 2622 0.257751036899837 3572 5511916
SGTC_3227 9130768 49.47 µM -0.650862992591073 0.228391992277858 no 2623 0.25756746624641 3593 17720899
SGTC_2023 5144124 124 µM -0.652179065829617 0.227933532996285 no 2624 0.257142831507204 3575 2830192
SGTC_1863 st057641 20.1 µM -0.65245910497449 0.227836047106222 no 2625 0.257052523081241 3620 3921635
SGTC_2159 5658611 73.75 µM -0.653250003281186 0.227560850104086 no 2626 0.256797559347618 3618 793844
SGTC_1992 st073643 23.3 µM -0.654161180800773 0.227244033522029 no 2627 0.256503984187968 3599 3161292
SGTC_1516 st013856 110 µM -0.656739427151362 0.226348924925118 no 2628 0.255674239128735 3596 5281404 A mutagen and neurotoxin.
SGTC_2845 9003024 42.97 µM -0.656922571726133 0.22628541713186 no 2629 0.255615351922697 3656 2990173
SGTC_803 4488-1585 147 µM -0.657205309089323 0.226187393995484 no 2630 0.255524456160874 3578 747204
SGTC_3300 9124615 50.48 µM -0.657715889421337 0.226010440039322 no 2631 0.255360355138946 3642 24824903
SGTC_830 4076-0286 57.8 µM -0.657807450209655 0.225978715712154 no 2632 0.255330933236906 3653 6866659
SGTC_545 4218-0007 221 µM -0.658919745200039 0.225593524662953 no 2633 0.254973652860026 3582 2840508
SGTC_1267 0828-0272 9.49 µM -0.660327205224466 0.225106650043132 no 2634 0.254521937695856 3648 745334
SGTC_949 1165-0505 146 µM -0.661117080888029 0.224833673875152 no 2635 0.254268616021275 3623 6244267
SGTC_350 k064-0020 19.8 µM -0.661509394679931 0.224698162430772 no 2636 0.254142845891605 3618 2790705
SGTC_2889 9059656 51.95 µM -0.661767717539805 0.224608958891094 no 2637 0.254060049136323 3662 3949838
SGTC_3229 9132204 49.47 µM -0.662246980219795 0.224443514070566 no 2638 0.253906474998038 3612 17682924
SGTC_2734 clemastine 41.6 µM -0.664161241254706 0.223783388027952 no 2639 0.25329355864006 3594 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1965 Pectolinarigenin 58.4 µM -0.66447757735744 0.223674407017615 no 2640 0.253192347726729 3617 5320438 An anti-inflammatory.
SGTC_2146 5545642 200 µM -0.667687652252988 0.222570211774605 no 2641 0.252166496767926 3646 825326
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.667785488639161 0.222536607082963 no 2642 0.252135265431687 3607 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1051 3253-3903 78 µM -0.668193073474568 0.222396641604952 no 2643 0.252005178137452 3608 5509239
SGTC_2904 7225135 42.03 µM -0.668374439313959 0.222334376345905 no 2644 0.251947303683351 3694 4446116
SGTC_1278 0874-0585 172 µM -0.66893610784272 0.222141611312514 no 2645 0.25176811785913 3624 766306
SGTC_1389 3405-0187 19 µM -0.669268892990505 0.222027444232082 no 2646 0.251661983114128 3569 799890
SGTC_1974 st069448 26.9 µM -0.671033522983454 0.221422620725719 no 2647 0.251099587025209 3589 6323587 YNR016C ACC1
SGTC_406 estrone 100 µM -0.671267679092732 0.221342435027761 no 2648 0.251025010340012 3648 5870 A steroid.
SGTC_1334 1486-0610 236 µM -0.672596665347563 0.220887644420113 no 2649 0.250601961886174 3627 3742339
SGTC_2285 7945142 200 µM -0.673524107967628 0.220570582713433 no 2650 0.250306958382669 3638 2970608
SGTC_1747 st037496 66.6 µM -0.673763449092269 0.220488802312399 no 2651 0.250230857997259 3664 723305
SGTC_3335 9143315 29.6265 µM -0.674404471612349 0.220269857119841 no 2652 0.25002710031542 3619 4899691
SGTC_887 0885-0007 9.62 µM -0.674883189795112 0.220106429314919 no 2653 0.249874990703541 3651 5719458
SGTC_431 k089-0097 107 µM -0.674981311060009 0.220072940655165 no 2654 0.249843819372176 3609 5499420
SGTC_1637 st007924 17.4 µM -0.676610274631815 0.219517404716656 no 2655 0.249326629183852 3631 683336
SGTC_1849 st056239 19.2 µM -0.677063413016506 0.219363011343393 no 2656 0.249182860597256 3590 5393181
SGTC_2868 9035608 32.47 µM -0.677144684298195 0.219335327181858 no 2657 0.24915708007551 3636 6462614
SGTC_1909 st060837 51.5 µM -0.677719260669988 0.219139661391764 no 2658 0.248974855939624 3614 678937
SGTC_2251 lansoprazole 556 µM -0.677760223871869 0.219125715648378 no 2659 0.248961867365776 3560 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.681818657148519 0.217746571493013 no 2660 0.247676812695218 3717 6710655
SGTC_2812 7970281 58.44 µM -0.682017600840506 0.217679095083779 no 2661 0.247613910747506 3668 2233435
SGTC_2939 9044578 71.43 µM -0.682245621557203 0.217601771361676 no 2662 0.247541825732555 3638 2653634
SGTC_797 k781-0471 270 µM -0.68243664805545 0.217537004890582 no 2663 0.247481444465632 3642 23738129
SGTC_2459 5811157 9.22 µM -0.683138372209526 0.217299184748675 no 2664 0.247259705147837 3622 2870684 YBR192W RIM2
SGTC_1214 0358-0031 63.7 µM -0.683482209837602 0.217182710154093 no 2665 0.247151093949047 3694 4301366
SGTC_1622 st003707 19.4 µM -0.684447865501826 0.216855788368262 no 2666 0.24684619979662 3681 10140899
SGTC_1380 2291-0730 164 µM -0.685960087406904 0.216344399156397 no 2667 0.24636913874183 3651 2999191
SGTC_1986 st071812 45 µM -0.686836006899786 0.216048508352621 no 2668 0.246093038362193 3630 11838594
SGTC_3161 9100388 49.47 µM -0.688036496345343 0.215643356934252 no 2669 0.245714899397691 3688 25236368
SGTC_263 alizarin 107.927 µM -0.688177835606328 0.215595685557707 no 2670 0.245670399858359 3672 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_234 nsc-17383 10.7 µM -0.688249076401504 0.215571659541685 no 2671 0.245647971902582 3679 408974
SGTC_1151 3909-8316 15.3 µM -0.688280475491253 0.215561070666172 no 2672 0.245638087221735 3674 800431
SGTC_3074 9116018 49.47 µM -0.688868683486024 0.215362762037241 no 2673 0.245452954200314 3695 17027303
SGTC_1028 k015-0029 4.8 µM -0.689166611864466 0.215262358767472 no 2674 0.245359212613303 3656 4588309
SGTC_1126 isoteolin 1.0172 µM -0.689564371977201 0.215128354084981 no 2675 0.245234089499333 3637 133323
SGTC_608 k048-0125 159 µM -0.689820874988441 0.215041964361843 no 2676 0.245153419728981 3681 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2596 sinensetin 100 µM -0.689991398317191 0.214984543579968 no 2677 0.245099798323714 3662 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1737 st035557 69.7 µM -0.690292147287719 0.214883293268584 no 2678 0.2450052425779 3568 5716916
SGTC_93 0109-0045 59.227 µM -0.691272297159277 0.214553507777798 no 2679 0.244697218825947 3734 88733
SGTC_42 0133-0086 60.653 µM -0.691766587690206 0.214387308298969 no 2680 0.244541961275235 3611 162923 Model of phenazepam hydroxylation.
SGTC_1114 scopoletin 1.73284 µM -0.693877336232247 0.21367843651285 no 2681 0.243879568856674 3675 5280460 A coumarin with genotoxic properties.
SGTC_1850 st056238 17 µM -0.694105227636796 0.213601983432169 no 2682 0.24380811022276 3676 5393177
SGTC_2296 7971656 126.45 µM -0.69480181086921 0.213368392303858 no 2683 0.243589756594139 3706 666570
SGTC_1080 nisoldipine 24.4 µM -0.696316085360921 0.21286111191359 no 2684 0.243115450912312 3664 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2787 5284540 71.43 µM -0.697286434134102 0.212536416473109 no 2685 0.242811778048632 3681 736958
SGTC_2835 9006588 71.43 µM -0.698608686429852 0.212094434070044 no 2686 0.24239830684265 3675 2345538
SGTC_724 3910-0327 137 µM -0.699671542183556 0.211739548747522 no 2687 0.242066226257842 3674 2885483
SGTC_2982 9019404 25.97 µM -0.701075312530429 0.211271365727342 no 2688 0.241628008059223 3563 22333232
SGTC_1259 0671-0132 43 µM -0.701655284420346 0.211078111706405 no 2689 0.241447082720047 3625 X1259
SGTC_2568 diosmetin 100 µM -0.703216384358469 0.210558448384597 no 2690 0.240960455044073 3660 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_699 0375-0592 111 µM -0.703874490993024 0.21033960116701 no 2691 0.240755469318977 3708 762578
SGTC_1056 3448-1962 115 µM -0.705923419374844 0.209659104887993 no 2692 0.240117881319973 3695 715507
SGTC_750 4073-0104 132 µM -0.706469849092212 0.209477841918785 no 2693 0.239947998261025 3553 22330957
SGTC_822 1487-0950 154 µM -0.707229507047793 0.209225999613034 no 2694 0.239711932245054 3682 1958375
SGTC_2322 7413319 38.22 µM -0.707898572183793 0.209004338387558 no 2695 0.239504123234162 3732 1840400
SGTC_2924 9010168 62.78 µM -0.708423946109071 0.208830379033286 no 2696 0.239341013119258 3734 2993929
SGTC_3115 9123671 49.47 µM -0.708625116077513 0.208763791169314 no 2697 0.23927857299253 3768 3286988
SGTC_3331 9141060 1.957 µM -0.709232115436383 0.20856294840756 no 2698 0.239090223488129 3685 4906567 YPR165W RHO1
SGTC_486 niguldipine 82 µM -0.709537327124548 0.208462003617058 no 2699 0.23899554813356 3701 1236 A calcium channel blocker.
SGTC_1484 3473-2379 286 µM -0.713253636216103 0.207235195744729 no 2700 0.237844410830388 3803 671917
SGTC_1778 st046819 58.9 µM -0.713286551103079 0.207224349170956 no 2701 0.23783422895313 3738 671715
SGTC_3158 9100007 49.47 µM -0.713563360293865 0.207133144421553 no 2702 0.237748610373751 3704 19297233
SGTC_1235 benzylparaben 21.5 µM -0.714316315597458 0.206885176371848 no 2703 0.237515802793307 3678 7180
SGTC_2484 5809818 12.04 µM -0.716351762478296 0.206215730075249 no 2704 0.236887086154767 3702 2870548
SGTC_1752 st044819 83.042 µM -0.718120279096298 0.205635119432511 no 2705 0.236341563653108 3689 441209 YML126C ERG13
SGTC_2347 9049783 174.81 µM -0.719598464522101 0.205150570909166 no 2706 0.235886128849277 3694 6467988 YPL169C MEX67
SGTC_485 niflumic acid 177 µM -0.720268008497756 0.204931318140067 no 2707 0.23567999898638 3725 4488 A COX2 inhibitor.
SGTC_2949 9072542 2.23 µM -0.721202586381849 0.204625508885509 no 2708 0.235392440367473 3759 16457352
SGTC_3280 9140961 49.47 µM -0.721556766736956 0.204509686228887 no 2709 0.235283513860539 3720 4901226
SGTC_2406 ethylparaben 405.7 µM -0.722107926640553 0.204329525716898 no 2710 0.235114062578215 3711 8434 A possible steroid mimic.
SGTC_1729 st035615 45.989 µM -0.722666976961737 0.204146882586512 no 2711 0.234942254310164 3766 17385451
SGTC_4 0960-0234 25.671 µM -0.722934302636399 0.204059581000367 no 2712 0.234860123867025 3691 6821112
SGTC_2792 7535235 81.82 µM -0.723166191436168 0.203983870189276 no 2713 0.234788893546255 3708 1281891
SGTC_509 pifithrin 175 µM -0.724469228963162 0.203558744759363 no 2714 0.23438885585473 3737 4817 A p53 inhibitor.
SGTC_1948 st076329 66.6 µM -0.726177484197742 0.203002215311338 no 2715 0.233864986557038 3619 24208413
SGTC_3243 9134147 49.47 µM -0.726189571762676 0.202998280565187 no 2716 0.233861281986116 3758 24282180
SGTC_979 1426-2828 121 µM -0.726932422608131 0.202756555049551 no 2717 0.233633677072047 3806 747872
SGTC_2323 6148992 148.28 µM -0.727514399385472 0.202567298561402 no 2718 0.233455448816943 3702 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2862 9027634 71.43 µM -0.727541829803556 0.202558380907307 no 2719 0.233447050213504 3647 5012562
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.727988604908074 0.202413166952398 no 2720 0.233310280894574 3656 17037758
SGTC_3137 9097352 49.47 µM -0.728500205839154 0.202246959333506 no 2721 0.233153721353099 3796 44120435
SGTC_787 4152-0075 138 µM -0.729047385033342 0.202069283522775 no 2722 0.232986338757827 3750 9566539
SGTC_1238 0333-0287 48.8 µM -0.729128633123354 0.202042909236203 no 2723 0.232961490587589 3732 7226
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.729423904983618 0.201947077136997 no 2724 0.232871199747287 3735 5106787 A p450 inhibitor.
SGTC_2528 xanthyletin 44.79 µM -0.729613442080278 0.201885576175467 no 2725 0.232813251664537 3778 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2357 9067248 200 µM -0.730683460558053 0.201538587168799 no 2726 0.232486260137194 3733 9150235
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.730831209288534 0.201490702831149 no 2727 0.232441129046156 3746 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_113 0099-0221 2.5 µM -0.732026279266854 0.201103639590556 no 2728 0.232076264033419 3727 89219
SGTC_664 1222-0054 14.9 µM -0.733277561587437 0.200698848376993 no 2729 0.231694578835647 3713 6813991
SGTC_3298 9116858 71.43 µM -0.734467370661971 0.200314397844168 no 2730 0.231331969815986 3746 2506942
SGTC_2655 perillic acid 100 µM -0.736429254513231 0.199681442015541 no 2731 0.23073475329931 3743 5702197 An apoptosis inducer.
SGTC_1635 st007035 42.4 µM -0.738337220240448 0.199067037253707 no 2732 0.230154776983801 3731 3716403
SGTC_3324 9138759 60.749 µM -0.738506147893765 0.199012693968004 no 2733 0.230103466314409 3766 45595710
SGTC_1276 0871-0068 94.2 µM -0.738670847131736 0.198959719552371 no 2734 0.230053446161002 3725 3414906
SGTC_929 2805-0021 398 µM -0.741385376737571 0.19808783392626 no 2735 0.229229904215042 3805 3098024
SGTC_789 1309-1135 70.6 µM -0.741488350271736 0.198054805117095 no 2736 0.229198696380804 3741 3092424
SGTC_2349 9023730 187.07 µM -0.741975078859042 0.197898731710515 no 2737 0.229051217476145 3722 4126287
SGTC_1053 3366-3204 134 µM -0.743221096012928 0.197499525050891 no 2738 0.228673916601754 3758 3632071 YPR165W RHO1
SGTC_3167 9103034 49.47 µM -0.743377555197801 0.197449432122527 no 2739 0.22862656457137 3756 5127859
SGTC_2200 6600604 21.907 µM -0.744480901371592 0.197096396240744 no 2740 0.228292795646009 3713 2904777
SGTC_2488 5268135 45.7 µM -0.746011779673068 0.196607196770461 no 2741 0.227830149604617 3791 1270356 YLR208W SEC13
SGTC_2539 epi(13)torulosol 80 µM -0.748130488559717 0.195931368004806 no 2742 0.227190726794118 3762 6708597
SGTC_1072 oxiconazole 14.9 nM -0.749655496918348 0.195445792188119 no 2743 0.226731108551738 3758 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2846 9008642 19.48 µM -0.75009398972771 0.195306307707109 no 2744 0.226599049549236 3795 2992898
SGTC_1102 cgs 12066b 26.1 µM -0.751034803588673 0.195007239156219 no 2745 0.226315855229517 3759 6438352 A 5-HT1B full agonist.
SGTC_2790 5423970 71.43 µM -0.75178078686635 0.19477030191969 no 2746 0.226091449029336 3801 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_691 1548-0686 185 µM -0.752847973881774 0.194431649407492 no 2747 0.225770637283068 3767 46495133
SGTC_2072 5231554 129 µM -0.753869297263197 0.194107886784206 no 2748 0.225463854076927 3818 789545
SGTC_636 0kpi-0074 126 µM -0.754549130051512 0.193892559892898 no 2749 0.225259778059699 3780 616434
SGTC_1705 st027868 56.3335 µM -0.756277333235946 0.193345833113536 no 2750 0.224741467621584 3777 292948
SGTC_340 k038-0059 454 µM -0.757948112815048 0.192818167925575 no 2751 0.22424102287822 3762 23733424
SGTC_2653 dihydrofissinolide 100 µM -0.758415045019238 0.19267085894654 no 2752 0.224101276962817 3812 6857746
SGTC_2456 5770359 74.46 µM -0.758900860785884 0.192517665556527 no 2753 0.223955931997375 3749 3118787
SGTC_609 0986-0026 86.3 µM -0.759562104355595 0.192309273803767 no 2754 0.223758189138187 3744 2848610
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.759880308204577 0.192209040642466 no 2755 0.223663066639453 3808 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1623 st003709 20.3 µM -0.760655718796519 0.191964922724056 no 2756 0.223431365021318 3760 16192618
SGTC_2007 4011539 71.82 µM -0.761158804660399 0.191806640730166 no 2757 0.223281110240658 3771 45595301
SGTC_1405 3909-7894 12 µM -0.761238228407001 0.191781659559528 no 2758 0.223257394303524 3771 7104060
SGTC_1669 st015249 58.4 µM -0.76391120231832 0.190942090495612 no 2759 0.222460080605421 3848 722793
SGTC_2330 7979373 200 µM -0.765098515612814 0.190569884997952 no 2760 0.22210644185942 3746 1863007
SGTC_421 streptovitacin 30 mM -0.765276652584908 0.190514080092943 no 2761 0.222053411837349 3875 91467 include heat shock
SGTC_1473 k844-0725 134 µM -0.766236055341806 0.190213700905651 no 2762 0.221767929255845 3842 54682906
SGTC_2192 5915882 198.485 µM -0.767068622168386 0.189953268705971 no 2763 0.221520358346982 3747 2876149
SGTC_2636 apigenin dimethyl ether 100 µM -0.769194212965898 0.18928936521995 no 2764 0.220889012682145 3784 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1912 st060209 90.8 µM -0.769345362789647 0.189242209799587 no 2765 0.220844157235688 3808 688787
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.769495188745844 0.189195474535289 no 2766 0.220799699809585 3804 23847180
SGTC_1826 st055655 41.6 µM -0.771369260600807 0.188611495187821 no 2767 0.220244044971831 3827 676168
SGTC_2869 9037858 32.47 µM -0.771561551750643 0.188551638288837 no 2768 0.220187076803668 3735 27187042
SGTC_2278 7948257 134.34 µM -0.772168233277614 0.188362865639806 no 2769 0.220007396758826 3756 1247028
SGTC_3038 9091290 49.47 µM -0.773440152116627 0.187967478939053 no 2770 0.219630967470806 3796 25236843
SGTC_1991 st073000 8.92 µM -0.773798342767554 0.187856224885962 no 2771 0.219525026349143 3846 4301969 YIL048W NEO1
SGTC_2495 cafestol 54.53 µM -0.774078467158876 0.18776924656289 no 2772 0.219442195141243 3775 16667697 An anti-infammatory.
SGTC_905 2-aminofluorene 215 µM -0.775196986653294 0.187422195465484 no 2773 0.219111634260004 3801 1539 An established DNA mutagen. YPR165W RHO1
SGTC_409 arachidonic acid 100 µM -0.775289937179959 0.187393372890306 no 2774 0.219084177081814 3796 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1680 diphenhydramine 100 µM -0.775793317223302 0.187237329831128 no 2775 0.218935515197729 3819 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1870 st057514 26.5 µM -0.776297360093958 0.187081161832737 no 2776 0.21878671572126 3797 5393161
SGTC_206 4546-0025 72.014 µM -0.778332355941779 0.186451477136508 no 2777 0.218186552735209 3821 6620745 YIL048W NEO1
SGTC_3332 9141069 11.198 µM -0.778438340402538 0.186418718581648 no 2778 0.218155321707508 3742 17332883
SGTC_2327 6189656 200 µM -0.778700728030263 0.186337632980832 no 2779 0.218078013578538 3865 5349088
SGTC_2416 tofa 880 nM -0.779265658786112 0.186163126715123 no 2780 0.217911619786309 3840 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2261 9010538 184.68 µM -0.779372921159222 0.186130004973397 no 2781 0.217880035172195 3769 6457250
SGTC_2854 9024559 71.43 µM -0.779629364695332 0.186050832117573 no 2782 0.217804533186382 3828 3163529
SGTC_118 0083-0097 135.343 µM -0.780454479102416 0.185796232873578 no 2783 0.217561705809499 3852 5207356
SGTC_1827 berberine 7.24 µM -0.783147119307274 0.184966889785076 no 2784 0.21677036195289 3744 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3198 9112019 49.47 µM -0.783994223422197 0.18470645499363 no 2785 0.216521749923653 3849 45595555
SGTC_483 fpl-64176 144 µM -0.784251096540421 0.184627526656437 no 2786 0.216446394224921 3829 3423
SGTC_275 trichlorophene 5.69 µM -0.784306937019643 0.18461037155953 no 2787 0.216430015000648 3850 62616
SGTC_2704 st078022 71.1 µM -0.788711623137779 0.183260304819621 no 2788 0.215140286494744 3829 54697681
SGTC_2054 5233173 129 µM -0.789162492708932 0.183122458409743 no 2789 0.215008520349907 3844 6889
SGTC_931 2812-0076 566 µM -0.791989833328071 0.182259517879989 no 2790 0.214183302142318 3830 3450959
SGTC_1897 st060201 15 µM -0.792724053944557 0.182035840685886 no 2791 0.213969306372795 3867 611878
SGTC_1314 1222-0010 41.1 µM -0.793533739417685 0.181789372535095 no 2792 0.213733460006971 3831 3526027
SGTC_2310 7668677 200 µM -0.794147763563894 0.181602602915278 no 2793 0.213554707153474 3800 2197143
SGTC_2614 arthonioic acid 13.39 µM -0.795180258907533 0.181288816463185 no 2794 0.21325432670882 3768 6710684
SGTC_903 1134-0042 114 µM -0.795239764528246 0.181270742418104 no 2795 0.213237022448037 3821 701009
SGTC_2720 fluspirilene 36.88 µM -0.797074256187819 0.180714093582841 no 2796 0.212703953315547 3806 3396 An atypical antipsychotic.
SGTC_2373 9071805 200 µM -0.79801609972671 0.180428722179707 no 2797 0.212430573672208 3792 10149009
SGTC_55 0767-0285 6.563 µM -0.799156366358285 0.180083608646052 no 2798 0.212099874584024 3771 3116166
SGTC_3035 9091303 49.47 µM -0.80113634311747 0.179485333462333 no 2799 0.211526359235356 3867 25237002
SGTC_1147 3809-1045 12.3 µM -0.803834177218338 0.178672162099301 no 2800 0.210746374298604 3817 325925
SGTC_1364 1653-0028 37.6 µM -0.804068726961526 0.178601574741408 no 2801 0.210678642200705 3841 5718652
SGTC_1640 st009078 66.4 µM -0.804964196827511 0.178332246107214 no 2802 0.210420170385291 3805 690618
SGTC_1687 st020778 55.3625 µM -0.805803667336518 0.178079992823679 no 2803 0.210178031573509 3842 4259299
SGTC_2541 muurolladie-3-one 83.07 µM -0.806637219937394 0.177829740512777 no 2804 0.209937761748325 3879 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1411 3909-8223 150 µM -0.807607282123264 0.177538784218891 no 2805 0.209658346654495 3831 X1411
SGTC_77 0828-0286 12.516 µM -0.808058235995567 0.177403629408846 no 2806 0.209528529152142 3800 745345
SGTC_2434 5670830 169.91 µM -0.808132711565613 0.177381314682044 no 2807 0.209507094187037 3884 1549830
SGTC_528 3492-0019 172 µM -0.808663965394745 0.177222189277273 no 2808 0.209354230367924 3850 2869262
SGTC_971 1315-0384 26.7 µM -0.8088812273374 0.177157139221198 no 2809 0.209291733987343 3872 6769120
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.80944387133472 0.176988748981701 no 2810 0.209129937945157 3902 5393153
SGTC_2521 angolensin 13.4 µM -0.80956133396547 0.176953607083126 no 2811 0.209096169240307 3924 821428 A flavenoid.
SGTC_66 0109-0187 42.4 µM -0.810102721341434 0.176791694441088 no 2812 0.208940570181084 3818 759417
SGTC_2098 5376439 882.5 nM -0.810596363419026 0.176644142631698 no 2813 0.208798752969194 3869 2844116
SGTC_607 4491-0986 66.8 µM -0.81090089410978 0.176553155903907 no 2814 0.208711293395762 3847 698981 YDR232W HEM1
SGTC_2166 5933061 31.504 µM -0.812058545033731 0.176207547143779 no 2815 0.208379019390558 3948 2877375
SGTC_386 1509-0011 3.07 µM -0.81261165445199 0.176042571378319 no 2816 0.208220373732387 3889 3107280
SGTC_1242 0402-0103 60.1 µM -0.81388035706996 0.175664525415143 no 2817 0.207856747317528 3792 432868
SGTC_1390 3413-2614 145 µM -0.814857770113166 0.17537362851659 no 2818 0.20757686413886 3902 3421432
SGTC_2865 9030313 51.95 µM -0.815188030298761 0.175275405811595 no 2819 0.207482344173452 3800 42562754
SGTC_2871 9038510 12.99 µM -0.815360576291798 0.175224102772148 no 2820 0.207432971890208 3813 4945164
SGTC_1253 0550-0034 176 µM -0.81702990655625 0.174728253233408 no 2821 0.206955668714394 3874 5969915
SGTC_3196 9111891 49.47 µM -0.817160827811355 0.17468940274256 no 2822 0.206918262566114 3852 18891510
SGTC_1817 st052116 64.4 µM -0.817534048405847 0.174578680752191 no 2823 0.206811649860042 3834 4361398
SGTC_129 0088-0017 176.636 µM -0.818056353278313 0.17442380531484 no 2824 0.206662504942827 3722 182446
SGTC_1290 0986-0249 10.2 µM -0.818063696270015 0.174421628570822 no 2825 0.206660408594974 3780 53329
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.819096028453451 0.17411577752247 no 2826 0.206365813829968 3895 5282309
SGTC_2905 7799065 20.05 µM -0.822326027687142 0.173161023014491 no 2827 0.205445683605772 3754 1296806
SGTC_2888 9058547 12.99 µM -0.82514520803902 0.172330432870503 no 2828 0.204644578110709 3781 16476514
SGTC_1628 st004252 77.7 µM -0.825887913785984 0.17211203975315 no 2829 0.204433838648156 3890 692968
SGTC_2923 7992654 58.14 µM -0.82768667320724 0.171583845705382 no 2830 0.20392398419162 3890 2985126
SGTC_95 0471-0001 561.058 µM -0.828470092549775 0.171354123810943 no 2831 0.203702162766663 3842 4015405
SGTC_1636 st007707 68.9 µM -0.829050748149247 0.17118398520961 no 2832 0.203537845788785 3883 403051
SGTC_1033 k072-0102 21.3 µM -0.830200646009507 0.170847371153018 no 2833 0.203212675031546 3826 5965931
SGTC_3182 9108849 49.47 µM -0.830665104449081 0.170711528607322 no 2834 0.203081422371976 3910 17133045
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.832923921506317 0.170051866827588 no 2835 0.202443818707592 3896 1377
SGTC_3275 9138069 49.47 µM -0.835740063959523 0.169231735918409 no 2836 0.201650575607299 3985 17617007
SGTC_653 0203-0016 55.2 µM -0.839156563730591 0.168240181023038 no 2837 0.200690729151721 3922 295302
SGTC_325 2810-4341 181 µM -0.841535172441947 0.167552059733799 no 2838 0.200024094712058 3894 774970
SGTC_213 1246-0773 967 nM -0.842249245966701 0.167345835672302 no 2839 0.19982422691215 3883 6251622
SGTC_1307 1187-1599 12.2 µM -0.845075333792785 0.166531268543497 no 2840 0.199034389606661 3895 1538471
SGTC_1482 3346-2049 8.48 µM -0.846850836534541 0.166020824296085 no 2841 0.198539134223395 3901 3826804
SGTC_2733 amorolfine 100 µM -0.847385425740355 0.165867331986843 no 2842 0.19839016264902 3945 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2356 9061756 188.97 µM -0.848723384851606 0.16548357672659 no 2843 0.198017615356592 3928 20104043
SGTC_1387 3342-1166 1.8 µM -0.850137097811557 0.165078718183343 no 2844 0.197624434223795 3894 3418228
SGTC_1035 k081-0041 55.2 µM -0.850240029200929 0.165049265798416 no 2845 0.197595825439508 3877 731709
SGTC_2833 9001315 45.46 µM -0.851869882444053 0.164583359440604 no 2846 0.197143157232519 3893 2989378
SGTC_1721 st082152 9.2685 µM -0.852326454674988 0.164452997643616 no 2847 0.197016463485281 3841 5296051
SGTC_1345 1488-0192 31.4 µM -0.854979762586391 0.163696742736266 no 2848 0.196281175689634 3907 658348
SGTC_838 0109-0203 71.4 µM -0.858705558633355 0.162638620745781 no 2849 0.195251491468917 3918 759422
SGTC_2444 5485484 36.41 µM -0.859661145021373 0.162367953802051 no 2850 0.1949879294749 4001 6790631
SGTC_3057 9095946 49.47 µM -0.86114415864321 0.161948475630992 no 2851 0.194579325418956 3925 24540043
SGTC_687 k029-0044 34.9 µM -0.863059202860983 0.161407840718836 no 2852 0.194052458618968 3992 5829338
SGTC_3172 9105863 49.47 µM -0.863473605895931 0.161291005941979 no 2853 0.193938562586412 3928 2348785
SGTC_2005 4024620 188 µM -0.864279697634876 0.161063898412522 no 2854 0.193717130135434 3903 236743
SGTC_3268 9137683 49.47 µM -0.864586147432273 0.160977614308123 no 2855 0.193632989193257 3948 1953228
SGTC_2163 5671233 125 µM -0.865368967105513 0.160757340340344 no 2856 0.193418154096896 3913 701023
SGTC_2067 5224629 34.075 µM -0.866452243783917 0.160452846955713 no 2857 0.193121102290862 3930 2835000
SGTC_861 0443-0273 110 µM -0.866873748364605 0.160334470026924 no 2858 0.193005594297341 3950 6149169
SGTC_570 0987-0065 62.6 µM -0.867205385147297 0.160241372036967 no 2859 0.192914743097418 3731 3104428
SGTC_3353 9151644 39.2805 µM -0.867313713664401 0.16021096941507 no 2860 0.192885072388162 3987 4909158
SGTC_1976 st070609 63.5 µM -0.868046340035688 0.160005455299295 no 2861 0.192684482394286 3827 682556
SGTC_1494 4358-1428 177 µM -0.868134612728741 0.159980704954995 no 2862 0.192660322313014 3931 1564571
SGTC_3204 9114183 49.47 µM -0.869661822359288 0.159552894589621 no 2863 0.192242620853708 3934 17027248
SGTC_524 r073-0010 27.8 µM -0.872113848810426 0.158867587139018 no 2864 0.191573135907488 3855 2772106
SGTC_2735 sertaconazole 140 nM -0.873730177643553 0.15841690215078 no 2865 0.191132606270025 4044 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_270 tamoxifen 5.46 µM -0.874248728399814 0.158272491224917 no 2866 0.190991407220222 3959 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1261 0712-0010 12.7 µM -0.877410691200756 0.157393787709973 no 2867 0.190131804110181 3943 2840123
SGTC_1900 st060200 72.8 µM -0.879454059335234 0.156827648482984 no 2868 0.189577565953665 3918 688945
SGTC_1305 1181-0477 144 µM -0.880526811363855 0.156530966959952 no 2869 0.189286993635889 4001 6252086
SGTC_125 0133-0007 11.75 µM -0.881710682931683 0.156203983301336 no 2870 0.188966641227231 4025 26541
SGTC_1810 st050138 53 µM -0.882078916958598 0.156102369403462 no 2871 0.188867066247531 3900 3444541
SGTC_211 3455-0679 143.504 µM -0.889205303634788 0.154144428369704 no 2872 0.186946376499748 4010 748649
SGTC_1923 st058458 19.1 µM -0.892678741780027 0.153196031452512 no 2873 0.186014618875009 4003 3534982
SGTC_2958 9077254 16.72 µM -0.892896017411847 0.153136834711952 no 2874 0.185956430036739 4031 16457351
SGTC_679 0422-0091 41.4 µM -0.89400454966809 0.152835051137672 no 2875 0.185659728448729 3937 627384 YHR062C RPP1
SGTC_3110 9122132 49.47 µM -0.894549688181559 0.152686788984721 no 2876 0.185513928481162 4067 918317
SGTC_2540 epiandrosterone 100 µM -0.894617323024024 0.152668400888435 no 2877 0.185495844167503 4004 441302 A steroid.
SGTC_2138 5575593 77.673 µM -0.894645903978821 0.152660630936374 no 2878 0.185488202474433 3935 762213
SGTC_1874 staurosporine 7.6 µM -0.894771214076689 0.15262656752038 no 2879 0.185454700605978 4012 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1911 st060208 74.3 µM -0.895818339116744 0.152342121538568 no 2880 0.185174896784521 4013 688783
SGTC_2431 5490079 200 µM -0.896015222737931 0.15228867846969 no 2881 0.185122316521264 4022 5722345
SGTC_3356 9151811 4.48 µM -0.897724255892283 0.15182529298314 no 2882 0.184666287312796 3951 1859254 YPR165W RHO1
SGTC_1075 aripiprazole 15.2 µM -0.898069495945177 0.151731798813686 no 2883 0.184574250186117 3990 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2822 7994718 71.43 µM -0.904012012270067 0.150128508690304 no 2884 0.182994515935475 3951 1018011
SGTC_1901 st060216 58.6 µM -0.905297669436111 0.149783129955924 no 2885 0.182653855379796 3948 688792
SGTC_1862 st057513 3.81 µM -0.90642627184107 0.149480379575843 no 2886 0.182355136228455 3953 5393163
SGTC_2044 5102272 200 µM -0.906696206821519 0.149408029419338 no 2887 0.182283734938001 4002 592666
SGTC_619 1652-1634 108 µM -0.908672089862468 0.148879149141422 no 2888 0.18176162046106 3945 5400454
SGTC_326 k292-0812 17.5 µM -0.908842650980894 0.148833554147792 no 2889 0.181716594682359 3955 3579357
SGTC_2800 7887935 81.82 µM -0.909889826995023 0.148553823934149 no 2890 0.181440307652068 4006 2961002
SGTC_2240 6690706 185.951 µM -0.91137509871528 0.148157669271916 no 2891 0.181048884689507 3840 805876
SGTC_1351 1496-0003 46.5 µM -0.912616637699141 0.147827066392133 no 2892 0.180722100419236 4019 3891978
SGTC_3171 9103192 49.47 µM -0.912816185685595 0.147773975919511 no 2893 0.180669612103708 4008 13018434
SGTC_2651 TUB2.036 5 µM -0.914126048179218 0.147425799199663 no 2894 0.180325308389426 3990 15992207 YFL037W TUB2
SGTC_302 1094-0063 18.9 µM -0.915039893940913 0.147183214128689 no 2895 0.180085343585576 3948 5440289
SGTC_1116 jasmonic acid 1.58368 µM -0.915722432936346 0.147002205294617 no 2896 0.179906247977236 4055 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2382 9035899 200 µM -0.916412604388868 0.146819324195561 no 2897 0.179725263428256 3981 6462679
SGTC_369 0957-0393 4.5 µM -0.918135870234245 0.146363361097175 no 2898 0.179273868806048 4025 6997992
SGTC_732 3970-1727 52.7 µM -0.918447761581684 0.146280938727023 no 2899 0.179192247819389 4055 1275699
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.919854573232541 0.145909553246657 no 2900 0.178824380178451 4117 16725076
SGTC_2706 st078239 82.5 µM -0.920614358106167 0.145709240686934 no 2901 0.178625901623376 3965 15434492
SGTC_2426 5582046 32.21 µM -0.921917577449112 0.145366085689697 no 2902 0.178285784899495 4011 2251934
SGTC_395 anisomycin 6.25 µM -0.924878996621138 0.144588327301778 no 2903 0.177514426514353 4019 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_97 0535-0701 19.132 µM -0.925011280673168 0.144553651033989 no 2904 0.177480019817142 3909 2832013 YGL099W LSG1
SGTC_1241 0364-0022 50.8 µM -0.926116244331307 0.144264220358638 no 2905 0.17719278644028 4021 4563895
SGTC_1487 3970-0795 2.82 µM -0.928823165740689 0.143556829613793 no 2906 0.176490368450364 4053 3765103
SGTC_1247 0448-0043 5.84 µM -0.929435630539097 0.143397101583408 no 2907 0.176331684861213 4045 3089013 YGL099W LSG1
SGTC_202 3594-0513 34.79 µM -0.930343482079967 0.143160558875157 no 2908 0.1760966356192 4003 708429
SGTC_1167 k781-0610 148 µM -0.930852595935866 0.143028023558544 no 2909 0.175964909253054 4030 4525169
SGTC_3051 9093778 49.47 µM -0.935297771598872 0.14187435330954 no 2910 0.174817431703133 4042 17217378
SGTC_2401 5128683 200 µM -0.936209627566241 0.14163847754193 no 2911 0.174582633598319 4005 708373
SGTC_2697 mebhydrolin 72.4 µM -0.937812392976852 0.141224523873809 no 2912 0.174170415557364 4104 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_3321 9137793 26.8275 µM -0.940673497798539 0.140487613748195 no 2913 0.173436102165498 3982 4904192
SGTC_3113 9123498 49.47 µM -0.941344484320066 0.140315172107088 no 2914 0.173264176612167 4103 8897275
SGTC_1435 4092-0789 56.7 µM -0.944136569751036 0.139599158010964 no 2915 0.172549931897031 4006 2248285
SGTC_525 k781-2675 26.7 µM -0.945010031494211 0.13937567493588 no 2916 0.172326877330455 3991 3651118 YDL195W SEC31
SGTC_2807 7945238 51.95 µM -0.945543024272321 0.139239423559625 no 2917 0.172190858207881 4078 17148797
SGTC_3206 9114350 49.47 µM -0.947115934324104 0.138837861939037 no 2918 0.171789852992499 3942 17087243
SGTC_1059 3448-6867 171 µM -0.947624125601904 0.1387082901857 no 2919 0.171660419861262 3940 3934407
SGTC_3066 9117245 49.47 µM -0.948968735369178 0.138365857115515 no 2920 0.171318256764928 4098 17176980
SGTC_901 1112-0062 60.1 µM -0.949712036581302 0.138176807383279 no 2921 0.171129296029813 4030 1908457
SGTC_256 clotrimazole 625 nM -0.950786429836964 0.137903859758101 no 2922 0.170856401324106 3956 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1010 4112-3296 15.2 µM -0.951751485378687 0.137659002943837 no 2923 0.170611515811921 4113 704384
SGTC_2725 haloperidol 53.21 µM -0.95181313952778 0.137643369956427 no 2924 0.170595878541259 3976 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_224 benfluorex 43.875 µM -0.952216157179487 0.137541210900812 no 2925 0.17049368424337 4041 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_21 0849-0113 22.993 µM -0.952398082433058 0.137495112480993 no 2926 0.170447565799704 3987 1560156
SGTC_173 1273-0061 2.693 µM -0.952881029355964 0.137372788723244 no 2927 0.170325176473591 4025 2847414 YPL266W DIM1
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.95433186690751 0.137005758739974 no 2928 0.16995784114958 4080 688664
SGTC_2511 berberine 10.47 µM -0.956094243970375 0.136560818214603 no 2929 0.169512311300704 4013 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2147 5545932 89.7195 µM -0.956737622983028 0.1363986333028 no 2930 0.16934985163803 4059 797404
SGTC_3070 9117005 49.47 µM -0.957687093148787 0.13615952881288 no 2931 0.169110283513025 4104 8779016
SGTC_2106 5357045 167.29 µM -0.95807146044802 0.13606281544935 no 2932 0.169013362755134 4070 668842
SGTC_501 nsc-95397 161 µM -0.960369997656649 0.135485445785964 no 2933 0.168434516186332 4106 262093
SGTC_1354 1498-1681 81 µM -0.960883581056189 0.135356668557277 no 2934 0.168305353598466 4045 5754243
SGTC_1914 st062367 72.6 µM -0.961084412131239 0.135306334479292 no 2935 0.168254863336876 4035 978205
SGTC_1943 st076331 65.2 µM -0.961205279416476 0.135276047825815 no 2936 0.168224481198361 4065 24208415
SGTC_1142 3253-1408 9.78 µM -0.962222697427852 0.135021289706747 no 2937 0.16796887501817 4032 256655
SGTC_2105 5350118 200 µM -0.963218734624122 0.134772204207962 no 2938 0.167718882628075 4038 2133313
SGTC_1764 st044502 93.5 µM -0.964342333538839 0.134491597184197 no 2939 0.167437161652316 4098 8407
SGTC_2606 farnesol 9.78 µM -0.966222987687968 0.134022821603614 no 2940 0.166966306226063 4108 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1527 coumarin 137 µM -0.96785372515446 0.133617250566816 no 2941 0.16655871389222 4158 323 A hepatotoxic, DNA x-linker.
SGTC_1490 4089-0339 670 nM -0.967975372923165 0.133587030133225 no 2942 0.166528334578509 3982 742542
SGTC_2194 5927483 104.545 µM -0.967986952287715 0.133584153766348 no 2943 0.166525443029646 4063 760979
SGTC_2411 st077133 39.94 µM -0.96988542021936 0.133113141500667 no 2944 0.166051804100193 4140 1403142 YNL221C POP1
SGTC_1171 0368-0077 21.4 µM -0.972513293124692 0.132463051050347 no 2945 0.165397627482947 4009 3239779
SGTC_1094 duloxetine 25.4 µM -0.972926009650092 0.132361151213688 no 2946 0.165295038486033 4051 60834 A selective serotonin reuptake inhibitor.
SGTC_2922 7999257 32.47 µM -0.973161418777768 0.132303052830422 no 2947 0.16523654125613 4012 2988377
SGTC_1141 3253-0389 52.6 µM -0.973809767978073 0.132143132752273 no 2948 0.165075501091087 4050 5402031
SGTC_269 exalamide 29 µM -0.97431201542405 0.132019341389303 no 2949 0.164950820265764 3965 3316 A derivative of salicylamide.
SGTC_2903 5923464 63.88 µM -0.975305268321004 0.131774765062967 no 2950 0.164704428988099 4072 2876576
SGTC_144 4161-2749 112.381 µM -0.982083881691086 0.130113962259578 no 2951 0.163029262738478 3999 797501 YMR168C CEP3
SGTC_1245 0418-0076 17.2 µM -0.984271820027966 0.129581009383782 no 2952 0.162490940628915 4135 6790114
SGTC_2336 9001819 198.65 µM -0.985598147301861 0.129258670777244 no 2953 0.162165173773927 4146 2989602
SGTC_841 0251-0215 91.2 µM -0.987143460839174 0.128883813245133 no 2954 0.161786157217719 4099 3888614
SGTC_1320 1313-0481 95.3 µM -0.987414288111124 0.128818194509238 no 2955 0.161719791347373 4069 6813365 YLR208W SEC13
SGTC_1181 1222-0449 220 µM -0.989295933948631 0.12836293042743 no 2956 0.161259186427415 4144 658318
SGTC_76 0433-0009 400.328 µM -0.992534846363431 0.127581894577436 no 2957 0.160468344837865 4171 2841569
SGTC_1408 3909-7976 48.8 µM -0.992545347752568 0.127579367643228 no 2958 0.160465784853652 4117 24152374
SGTC_2543 pimpinellin 60.67 µM -0.995343159021281 0.126907373606958 no 2959 0.159784696816436 3910 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_170 4197-0004 226 µM -0.997299177777827 0.126439031954007 no 2960 0.159309656360828 4120 218692
SGTC_3307 9126885 69.2785 µM -0.99855694994824 0.126138512660443 no 2961 0.159004681737038 4068 24824909
SGTC_694 1315-0438 43.2 µM -0.999175988273781 0.125990788913323 no 2962 0.158854722794348 4060 6793154
SGTC_210 3551-0445 56.827 µM -1.00156230940088 0.12542245994288 no 2963 0.158277516096044 4138 2865180 YOR207C RET1
SGTC_2772 vinpocetine 57.06 µM -1.00200879165077 0.12531632425221 no 2964 0.158169673365429 4123 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2141 5621638 7.665 µM -1.00267640701913 0.12515773882339 no 2965 0.158008508421741 4117 2856238
SGTC_2512 diallyl trisulfide 49.23 µM -1.00295540570411 0.125091506983429 no 2966 0.157941189007765 4103 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1505 k297-0037 20.6 µM -1.00497457884273 0.124612902612743 no 2967 0.157454545428731 4103 4089396
SGTC_878 0828-0289 13.7 µM -1.00569031166019 0.124443560220973 no 2968 0.15728228253848 4040 745350 YLR208W SEC13
SGTC_1853 st056710 91.2 µM -1.00716900553551 0.124094211030625 no 2969 0.156926782413945 4164 269167
SGTC_3210 9128157 49.47 µM -1.00806915276707 0.123881882822112 no 2970 0.156710632610116 4142 17590849
SGTC_3290 9121031 71.43 µM -1.00893992272417 0.123676726272361 no 2971 0.156501723642711 4115 17014854
SGTC_2718 lomofungin 53.02 µM -1.01209384982058 0.122935641401012 no 2972 0.155746591362524 4089 5351222 A RNA synthesis inhibitor.
SGTC_1225 1216-0074 20.6 µM -1.01306453503755 0.122708185322433 no 2973 0.155514668369793 4127 4241466
SGTC_354 2783-3500 4.88 µM -1.01669834561759 0.121859313231564 no 2974 0.154648476504431 4112 6740761
SGTC_1013 4112-3890 241 µM -1.01694807875667 0.12180112648322 no 2975 0.154589064895222 4057 705171
SGTC_3154 9100113 49.47 µM -1.01882027978936 0.121365533356651 no 2976 0.154144148044949 4131 25237525
SGTC_2610 ononetin 44.17 µM -1.01904789208449 0.121312651019633 no 2977 0.15409011521344 4107 259632
SGTC_460 trequinsin 123 µM -1.01970268110447 0.121160610873967 no 2978 0.153934744873524 4156 5537 A vasodilator.
SGTC_1347 1493-0251 600 nM -1.021658609015 0.120707248298225 no 2979 0.153471253868486 4162 3986378
SGTC_348 k064-0012 10.7 µM -1.02230362115815 0.120558003751305 no 2980 0.153318609945086 4019 5066323
SGTC_1574 spiramycin 23.7 µM -1.02946484172343 0.118909747968665 no 2981 0.151630646420743 4088 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1093 fluphenazine 7.97 µM -1.0306182273352 0.118645775210853 no 2982 0.151359942523013 4130 6602611 An atypical antipsychotic.
SGTC_430 0958-0115 16.4 µM -1.03635114818962 0.117339838688877 no 2983 0.150019176098985 4086 6833180
SGTC_1325 1431-0015 227 µM -1.03874193111548 0.11679824686044 no 2984 0.149462387156731 4121 1103340
SGTC_2376 9072922 81.32 µM -1.03923879950077 0.116685912419171 no 2985 0.149346844919813 4156 17087968
SGTC_3088 9117578 49.47 µM -1.03969245111859 0.116583415556839 no 2986 0.149241404440538 4175 678341
SGTC_823 0417-1665 178 µM -1.04138473479574 0.11620162878808 no 2987 0.148848512199298 4119 3429856
SGTC_2694 st077685 81.9 µM -1.04159747029239 0.116153697559999 no 2988 0.148799171010595 4080 2838096
SGTC_3079 9117512 49.47 µM -1.04235413983797 0.115983326798275 no 2989 0.148623760095769 4181 7185044
SGTC_1012 4112-3522 18 µM -1.04554266565695 0.115267351417334 no 2990 0.147886116087721 4167 3112398
SGTC_2649 anisomycin 9.56 µM -1.05144613623223 0.11395004705874 no 2991 0.146526867867431 4161 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1664 st014217 9.02 µM -1.0517810370132 0.113875639908578 no 2992 0.146450010586218 4191 3982782
SGTC_3304 9125678 46.087 µM -1.0521104580862 0.113802484005838 no 2993 0.146374437264849 4081 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_152 4469-0003 551.229 µM -1.05295029022551 0.113616130563498 no 2994 0.146181887735988 4046 697280
SGTC_2177 5811945 192 µM -1.05614291099834 0.11290969395607 no 2995 0.14545146411736 4200 5343475
SGTC_1711 st032263 62.8 µM -1.05740713272292 0.112630825877926 no 2996 0.145162908824052 4155 3958979
SGTC_219 mitoxanthrone 164.414 µM -1.06047908930612 0.111955249721687 no 2997 0.144463349066488 4100 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2504 purpurogallin 52.29 µM -1.0615607887992 0.11171805652062 no 2998 0.144217561280412 4054 5281571 An antioxidant.
SGTC_2505 galangin 7.89 µM -1.06183679604591 0.111657591733177 no 2999 0.144154891057206 4035 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1159 4092-0538 61.2 µM -1.06538887322849 0.110881528449187 no 3000 0.143349994927226 4195 717301
SGTC_1518 st038567 90.8 µM -1.06821777217523 0.110266236228181 no 3001 0.142711144918726 4107 77966
SGTC_1960 st011366 51.8 µM -1.0691180524934 0.110070937726623 no 3002 0.142508239064814 4164 3972846
SGTC_2799 7812892 81.82 µM -1.07044974799778 0.109782507223788 no 3003 0.142208458455298 4193 20205235
SGTC_3342 9147791 14.508 µM -1.07193076845362 0.109462372214164 no 3004 0.141875564554842 4080 1838168
SGTC_2191 5911152 200 µM -1.07251386137606 0.109336515907801 no 3005 0.141744645702569 4170 2875902
SGTC_2217 6934799 96.0675 µM -1.07328387515604 0.1091704734356 no 3006 0.14157188388125 4144 675606
SGTC_772 k072-0172 35.3 µM -1.07683005429019 0.108408129213022 no 3007 0.140778097953644 4204 5861980
SGTC_741 4582-0002 126 µM -1.07692195196441 0.108388424444443 no 3008 0.140757567563692 4156 2912688
SGTC_585 0kpi-0023 191 µM -1.07871787031949 0.108003859473062 no 3009 0.140356758406572 4109 64601
SGTC_3045 9092950 49.47 µM -1.07890863426446 0.107963068455549 no 3010 0.140314229703095 4109 44120432
SGTC_3047 9092122 49.47 µM -1.0802818914605 0.107669752486427 no 3011 0.140008335522723 4151 17173831
SGTC_2883 9059145 45.46 µM -1.08128520341836 0.107455816913864 no 3012 0.139785133632319 4174 16476510
SGTC_735 3076-0345 636 µM -1.0824464722428 0.107208583023867 no 3013 0.139527094014303 4235 2888990
SGTC_1940 st075990 51.1 µM -1.08328835879474 0.107029602196532 no 3014 0.139340225390986 4270 1084979
SGTC_918 glabranin 770.725 nM -1.08374787312271 0.106932002741009 no 3015 0.139238301554067 4185 124049 Also referred to as licorice root.
SGTC_1428 4049-0204 61.7 µM -1.08375410498255 0.106930679554221 no 3016 0.139236919628062 4236 X1428
SGTC_1588 farnesol 29.9 µM -1.08474242818689 0.106720982150871 no 3017 0.139017875305318 4181 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1067 clotrimazole 1.36 µM -1.08690019685335 0.106264189376391 no 3018 0.13854045966152 4206 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_974 1326-0144 138 µM -1.08760919880001 0.106114404593487 no 3019 0.138383834044324 4210 5411856
SGTC_964 1287-0107 19.4 µM -1.08996363711245 0.105618096923913 no 3020 0.137864581144617 4197 51516812 YPR165W RHO1
SGTC_1019 4262-0212 3.4 µM -1.09026393482422 0.105554916069711 no 3021 0.137798448546466 4207 4677213
SGTC_3248 9135562 49.47 µM -1.09096142830767 0.105408273061343 no 3022 0.13764492765923 4170 17650701
SGTC_2051 5263410 176 µM -1.09459859466792 0.104645972381864 no 3023 0.13684626577536 4180 227584
SGTC_967 1306-0166 352 µM -1.09867031995183 0.103797340331346 no 3024 0.135955946502834 4213 4437607
SGTC_2513 baicalein 25.65 µM -1.10070079832293 0.103376016824509 no 3025 0.135513449348597 4207 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_805 3852-0218 479 µM -1.10210287907919 0.103085811089752 no 3026 0.135208473940002 4158 6615355
SGTC_1795 st049545 62.3 µM -1.10246818842382 0.103010295825998 no 3027 0.135129090539621 4159 5291882
SGTC_297 0986-0032 24 µM -1.10306905142579 0.102886175283175 no 3028 0.134998589771345 4135 2847425
SGTC_565 1418-0001 44.5 µM -1.10338868294912 0.102820193146968 no 3029 0.134929204588312 4265 2862145
SGTC_873 0591-4978 488 µM -1.10469484863245 0.102550878466113 no 3030 0.134645918149503 4272 3305145
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.10497139258398 0.102493924476579 no 3031 0.134585992589799 4209 5379071
SGTC_3102 9121669 49.47 µM -1.10701859378663 0.102073020285234 no 3032 0.134142944678725 4242 41905072
SGTC_1949 st076024 69.1 µM -1.10791959117119 0.101888174471728 no 3033 0.133948271930637 4122 2921930
SGTC_1190 1486-1332 13 µM -1.10928016259299 0.101609505802642 no 3034 0.133654670052242 4184 4150046
SGTC_382 3229-0966 23.2 µM -1.10959000160628 0.101546123047043 no 3035 0.13358787084468 4234 5722370
SGTC_1103 duloxetine 36.1 µM -1.10981298907425 0.101500525049935 no 3036 0.133539810455151 4278 60835 A selective serotonin reuptake inhibitor.
SGTC_2048 5246248 200 µM -1.11368867824711 0.100710378430988 no 3037 0.132706384023894 4236 677046
SGTC_447 ml7 120 µM -1.11431826194841 0.100582448318225 no 3038 0.132571337625059 4239 4216 Selective myosin light chain kinase inhibitor.
SGTC_2018 5133068 143 µM -1.11658894615822 0.100122034792907 no 3039 0.132085060038338 4159 785362
SGTC_1749 st037932 54.2 µM -1.11869860355884 0.0996956523551611 no 3040 0.131634370574017 4239 594497
SGTC_883 0850-0245 24.6 µM -1.12310495182685 0.0988093684566662 no 3041 0.130696461653253 4282 6823229 YPR165W RHO1
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.1244211108582 0.098545760534182 no 3042 0.130417210167196 4222 688669
SGTC_785 1270-0111 65.3 µM -1.1296308794888 0.0975073701513695 no 3043 0.129315896817898 4146 6741994
SGTC_3005 9076496 71.4286 µM -1.13074328783569 0.0972866928166356 no 3044 0.129081577993626 4184 21368410
SGTC_2564 betulinic acid 100 µM -1.13133760035228 0.097168944581101 no 3045 0.128956512127063 4287 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_683 panaxydol 45 µM -1.13150594658733 0.0971356099798815 no 3046 0.128921100980901 4209 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_105 0111-0055 734.78 µM -1.1359381197786 0.0962610026176955 no 3047 0.127991231548345 4238 5179370
SGTC_247 mechlorethamine 29.705 µM -1.13686275750404 0.0960792744752852 no 3048 0.127797831562211 4136 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1009 4106-0057 9.87 µM -1.13857314395394 0.0957437805038143 no 3049 0.127440617558257 4229 2928005
SGTC_882 0843-0131 351 µM -1.14209981046304 0.0950547434964019 no 3050 0.126706267117872 4235 5425421
SGTC_1758 st042942 75.2445 µM -1.14407903982336 0.0946696470793845 no 3051 0.126295429668531 4208 669317
SGTC_784 4579-0127 173 µM -1.14496192871923 0.0944982357527006 no 3052 0.126112464230032 4265 1948547
SGTC_293 4049-0273 38.5 µM -1.14800231696007 0.0939097005517471 no 3053 0.125483803673078 4105 1380311
SGTC_414 piperonyl butoxide 100 µM -1.14888291127181 0.0937397480925383 no 3054 0.125302132503579 4237 5794 A potent inhibitor of cytochrome P450.
SGTC_2161 5662504 8.5105 µM -1.14960553380741 0.0936004534880826 no 3055 0.125153188959208 4202 2859334
SGTC_181 1447-1644 8.07 µM -1.15183912167595 0.0931708676918547 no 3056 0.124693594230042 4223 534600
SGTC_2581 avocatin a 64 µM -1.15269172465595 0.0930072714276638 no 3057 0.124518469638283 4206 6710728 A skin care supplement.
SGTC_729 4092-0585 94.1 µM -1.15445457637577 0.0926696914749495 no 3058 0.124156925520534 4253 2169061
SGTC_2229 7354935 190 µM -1.16102794599582 0.0914189032417849 no 3059 0.122815267407995 4189 318112
SGTC_3019 9081971 49.47 µM -1.16308557369835 0.091029958783603 no 3060 0.122397392314063 4272 16451803
SGTC_2197 6588183 93.1375 µM -1.16337519355565 0.0909753118840577 no 3061 0.122338654821871 4209 884136
SGTC_2785 7756463 72.73 µM -1.16393916248065 0.0908689692918416 no 3062 0.122224333669936 4215 2201551
SGTC_2795 7780010 54.55 µM -1.16603390652102 0.0904747895210541 no 3063 0.121800368473591 4223 953673
SGTC_3325 9138760 55.175 µM -1.16938724179975 0.0898464186163621 no 3064 0.121123823869027 4194 43844959
SGTC_1006 4099-6547 255 µM -1.17082869252865 0.0895773088029234 no 3065 0.120833821089532 4272 3146833
SGTC_584 0986-0246 15.4 µM -1.17099638123997 0.0895460413335411 no 3066 0.120800115869091 4357 53315 YDR232W HEM1
SGTC_2190 6049624 200 µM -1.17284020821521 0.0892027739057229 no 3067 0.120429945319815 4140 2265554
SGTC_481 bay k-8644 50 µM -1.17328256720558 0.0891205652402919 no 3068 0.120341255358427 4236 2303 A calcium channel antagonist.
SGTC_1879 gemcitabine 100 µM -1.17368299910065 0.0890461970023627 no 3069 0.120261011177272 4233 60750 A nucleoside analog which inhibits DNA replication.
SGTC_3272 9137413 49.47 µM -1.17371168615415 0.0890408710144901 no 3070 0.120255263908967 4158 17614870
SGTC_673 1082-0474 110 µM -1.17450893417503 0.0888929501931535 no 3071 0.120095617761133 4272 3098046
SGTC_1040 k898-0338 155 µM -1.17486207373155 0.0888274874328636 no 3072 0.120024950544026 4259 20969351
SGTC_1519 esterone 74 µM -1.17721091243368 0.0883929878070213 no 3073 0.119555667095378 4223 698 A steroid.
SGTC_532 1548-0774 215 µM -1.17793642129349 0.0882591003015542 no 3074 0.11941097689768 4373 5932993
SGTC_3222 9128301 49.47 µM -1.17835362398767 0.0881821769901845 no 3075 0.119327829009859 4263 4911358
SGTC_2558 carylophyllene oxide 100 µM -1.17893485309614 0.0880750940195266 no 3076 0.119212059021277 4390 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2714 st079313 56.9 µM -1.18001958352437 0.0878755076385565 no 3077 0.118996213059454 4257 2939799
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.18064241158498 0.0877610621318458 no 3078 0.118872403900944 4259 688751
SGTC_2817 7995342 71.43 µM -1.18792269149141 0.0864315361755062 no 3079 0.11743193442566 4276 18879975
SGTC_2713 st079149 53.4 µM -1.19433455792644 0.0852731228626771 no 3080 0.116173562342734 4301 3103253
SGTC_2059 5238311 157 µM -1.19568217665414 0.0850311386327422 no 3081 0.115910304640523 4232 703021
SGTC_1844 rapamycin 4 nM -1.19814672823124 0.0845899250402137 no 3082 0.115429950018509 4162 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2913 7966556 36.57 µM -1.19824238034081 0.0845728357110675 no 3083 0.11541133545753 4170 2976516
SGTC_969 1313-0238 134 µM -1.19968500838223 0.0843154079077732 no 3084 0.115130848762013 4318 5212874
SGTC_313 3474-0040 5.03 µM -1.20315145184039 0.0836992477744509 no 3085 0.114458858926762 4297 1043375 YIL048W NEO1
SGTC_2306 7482397 179.52 µM -1.20368924685559 0.0836039586289844 no 3086 0.114354854997632 4298 891448
SGTC_146 3448-8650 53.125 µM -1.20773145559799 0.0828903475939875 no 3087 0.11357528725485 4264 2891488 YIL048W NEO1
SGTC_272 doxorubicin 8.13 µM -1.2087555947386 0.0827102758752347 no 3088 0.113378378006425 4303 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2010 4012422 159 µM -1.20965751611093 0.0825519373130772 no 3089 0.113205169071604 4240 952393
SGTC_1594 piperine 70.1 µM -1.21081963403284 0.0823482559829205 no 3090 0.112982269302893 4275 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1645 Cervolide 78 µM -1.21100101543327 0.0823164999159236 no 3091 0.112947507764426 4297 23173 A fragrance.
SGTC_3348 9149464 3.537 µM -1.21125414819175 0.0822721971126575 no 3092 0.112899007922121 4232 1951442
SGTC_1804 st050076 49.1 µM -1.21644374553784 0.0813678772161038 no 3093 0.111907964097809 4317 3895976
SGTC_2365 9042475 200 µM -1.2185096956436 0.0810099663558588 no 3094 0.111515171288846 4353 6464479
SGTC_276 colchicine 750 µM -1.21890480251862 0.080941652519142 no 3095 0.111440163340307 4364 2833 A microtubule depolymerizer.
SGTC_1502 4534-4282 27.7 µM -1.22025287431283 0.0807088986714309 no 3096 0.111184514245184 4256 3278949
SGTC_138 0850-0259 40.9225 µM -1.22255464634649 0.0803126507307169 no 3097 0.110748976023639 4242 6813004
SGTC_947 3447-0010 211 µM -1.22492363738627 0.0799063680616913 no 3098 0.110301996734131 4269 748350
SGTC_1135 dihydrocapsaicin 536.708 nM -1.22499957214604 0.0798933709833091 no 3099 0.110287690855471 4213 107982 A Capsaicinoid.
SGTC_1393 3470-5649 58.2 µM -1.2290427480943 0.0792036428861242 no 3100 0.109527889415917 4278 4108395
SGTC_337 1315-0038 354 µM -1.22931146735118 0.0791579621636767 no 3101 0.109477524719227 4281 1626437
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.23010471696219 0.0790232306749774 no 3102 0.109328946964159 4362 91467 include heat shock
SGTC_2884 9058502 51.95 µM -1.23014547293534 0.0790163130674414 no 3103 0.109321317176604 4336 6471554
SGTC_826 1683-5028 118 µM -1.23305055548493 0.0785244071501367 no 3104 0.108778451509283 4351 722377
SGTC_622 1348-1566 26.3 µM -1.23415145886897 0.0783386033580975 no 3105 0.108573235700609 4307 7340407
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.23680197572279 0.0778926329311907 no 3106 0.108080304209789 4302 688667
SGTC_3026 9090633 49.47 µM -1.23823044648224 0.0776530817755463 no 3107 0.10781531262296 4317 25236842
SGTC_3109 9122853 49.47 µM -1.23855520975302 0.0775986978614032 no 3108 0.107755132050112 4346 1234709
SGTC_1781 st038725 66.3 µM -1.2388842421382 0.0775436285496749 no 3109 0.107694185066167 4307 4270275 YIL048W NEO1
SGTC_2351 9026858 72.31 µM -1.23945051603229 0.0774489222229772 no 3110 0.107589351768187 4219 1409300
SGTC_300 r073-0011 5.04 µM -1.23956868826817 0.0774291696221178 no 3111 0.107567484025233 4316 2735780
SGTC_2379 9035213 200 µM -1.23989121050711 0.0773752791962781 no 3112 0.107507817664653 4315 646551
SGTC_3239 9133757 49.47 µM -1.24024911903639 0.0773155094092597 no 3113 0.107441632793007 4353 17036923
SGTC_773 4358-1457 44.6 µM -1.24211399114445 0.0770046479818818 no 3114 0.107097253559295 4326 1186886
SGTC_330 1488-0319 80.1 µM -1.24400266483577 0.0766907881483491 no 3115 0.106749291080112 4363 6846614
SGTC_1558 st069300 45.6 µM -1.24479757889887 0.0765589805723273 no 3116 0.10660308316838 4268 24208000
SGTC_1237 0330-0133 46.1 µM -1.24497396513488 0.0765297567055972 no 3117 0.106570660192998 4255 X1237 YHR072W ERG7
SGTC_2621 lithochol-11-enic acid 100 µM -1.24737536228019 0.0761327342877155 no 3118 0.106129948041668 4291 6708711
SGTC_3103 9120822 49.47 µM -1.24803463433254 0.0760240117687715 no 3119 0.106009186983084 4321 17141819
SGTC_3301 9125354 19.7965 µM -1.24812111766228 0.0760097583199017 no 3120 0.105993352913043 4310 41905162
SGTC_10 0279-0212 42.575 µM -1.24832934825141 0.075975447867477 no 3121 0.105955235377795 4307 39851 YBR002C RER2
SGTC_2238 6671620 73.2395 µM -1.25035552400883 0.0756422073682407 no 3122 0.10558485196001 4238 729941
SGTC_1619 st003326 88.7 µM -1.25075019569548 0.0755774263908835 no 3123 0.105512815348062 4311 2849032
SGTC_433 pimozide 108 µM -1.25307555096248 0.0751966030773315 no 3124 0.105089106397251 4246 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2897 9048598 12.99 µM -1.25380598044124 0.0750772831420145 no 3125 0.104956267473963 4291 6467404
SGTC_445 e6 berbamine 66 µM -1.25579906767426 0.0747524351808114 no 3126 0.104594414867785 4350 6610268 A calcium/calmodulin antagonist.
SGTC_3245 9134821 49.47 µM -1.2561183680221 0.0747004930926613 no 3127 0.104536528754979 4347 17014901
SGTC_3163 9099914 49.47 µM -1.2572001689974 0.0745247161642023 no 3128 0.104340581064664 4391 16268368
SGTC_1131 3454-3128 32.3 µM -1.25909057247026 0.0742183112552455 no 3129 0.103998809617807 4348 710982
SGTC_1045 1348-1485 165 µM -1.25990426350091 0.0740867212123877 no 3130 0.103851950266528 4318 6810614
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.26181285611141 0.073778763178707 no 3131 0.103508067501937 4368 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2526 patulin 37.61 µM -1.26344792377215 0.0735157183044821 no 3132 0.103214125273128 4365 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2016 5121758 140 µM -1.26383476424389 0.0734535895801201 no 3133 0.103144670267791 4277 2795203
SGTC_1236 0330-0013 258 µM -1.26536349808496 0.0732084592854794 no 3134 0.102870526913398 4352 4617066
SGTC_840 0245-0196 390 µM -1.26547212817894 0.073191064450704 no 3135 0.10285106676264 4427 3827528
SGTC_1955 wogonin 32.4 µM -1.26815222381599 0.0727629040123899 no 3136 0.102371797362404 4372 5281703 A flavanone.
SGTC_2036 5160441 105 µM -1.2695370163496 0.0725424283574836 no 3137 0.102124798484739 4315 134534 YIL048W NEO1
SGTC_2878 9043973 25.97 µM -1.27236321425037 0.0720940519295871 no 3138 0.101622048919865 4371 6465167
SGTC_221 trifluoperazine 10.304 µM -1.27316232644534 0.0719676588073926 no 3139 0.101480223012121 4324 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2957 9076800 11.52 µM -1.27337347275319 0.0719342908382222 no 3140 0.1014427729941 4318 16459615
SGTC_771 0250-0039 27.3 µM -1.27681009302747 0.0713928597523789 no 3141 0.100834650679905 4313 3005115
SGTC_2364 9055074 200 µM -1.27726201371995 0.0713218940752113 no 3142 0.100754879870814 4358 6470630
SGTC_2677 mitomycin C 100 µM -1.27802985179697 0.0712014436675066 no 3143 0.100619450427482 4416 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3187 9109394 49.47 µM -1.28110230590828 0.0707210315503536 no 3144 0.100078867015765 4362 17098090
SGTC_526 4469-0568 170 µM -1.28682100563324 0.0698334873573123 no 3145 0.0990783418353649 4317 2901964
SGTC_676 falcarinol 140 µM -1.28871044990008 0.0695421367122042 no 3146 0.0987493840909708 4387 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2635 hydroquinidine 100 µM -1.29309766141531 0.0688692430584727 no 3147 0.0979886419372093 4285 442912 An experimental heart treatment.
SGTC_1193 1488-0126 41.5 µM -1.29333555846726 0.06883289929685 no 3148 0.0979475137011828 4330 1384710
SGTC_2149 5554786 194.827 µM -1.30018984433156 0.0677921016008253 no 3149 0.0967679552442453 4396 745063 YPR165W RHO1
SGTC_2131 toluylene red 5.2905 µM -1.30628643204426 0.0668766094547498 no 3150 0.0957275846926287 4334 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_3036 9090181 49.47 µM -1.30939409261958 0.0664136437111965 no 3151 0.0952004457445881 4423 25236586
SGTC_165 k038-0023 64.381 µM -1.30946312264015 0.0664033881635025 no 3152 0.0951887607989182 4367 46368543
SGTC_643 k048-0106 28.4 µM -1.31104431900667 0.0661688109422455 no 3153 0.094921395423953 4391 6763920
SGTC_2113 5491891 107.031 µM -1.31140037783823 0.066116076747107 no 3154 0.0948612656322173 4364 789979
SGTC_455 paf C-16 10 µM -1.31234887722306 0.0659757578536878 no 3155 0.0947012238187211 4335 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1155 4088-0394 48.2 µM -1.31645045171251 0.0653716349703567 no 3156 0.0940114491765756 4364 2326248
SGTC_2961 9083290 32.55 µM -1.31693855623306 0.0653000284493595 no 3157 0.0939296105917069 4314 17741490
SGTC_3078 9116413 49.47 µM -1.31738185785464 0.0652350474007106 no 3158 0.0938553295049424 4316 17177322
SGTC_1209 2323-2347 50.3 µM -1.31936329238053 0.0649452133658351 no 3159 0.0935238437512171 4371 5412760
SGTC_1786 berberine 21.6 µM -1.32375076426461 0.064306994595572 no 3160 0.0927929164266812 4286 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2489 cantharidin 73.42 µM -1.32544397686866 0.0640620007781832 no 3161 0.0925119696028419 4342 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2122 5258151 111.688 µM -1.32830687680493 0.0636494144455906 no 3162 0.0920383744346576 4394 2173356
SGTC_871 0574-0004 149 µM -1.33160908554681 0.0631760881663634 no 3163 0.0914943389142791 4350 9551173
SGTC_2811 7967822 32.47 µM -1.33244347043588 0.0630569254035995 no 3164 0.0913572528026768 4423 2232244
SGTC_1651 st011928 86.1 µM -1.33254698701395 0.0630421538876783 no 3165 0.0913402560641489 4396 720198
SGTC_2222 6885208 172.143 µM -1.33490793761584 0.0627059842857657 no 3166 0.090953239772223 4392 609514
SGTC_1608 st001473 40.5 µM -1.33534606791934 0.0626437540206667 no 3167 0.0908815537501095 4331 7292267
SGTC_2040 5100729 123 µM -1.33642347357853 0.0624909283882512 no 3168 0.0907054490496293 4419 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_812 4251-0442 148 µM -1.34125594925289 0.0618090344318376 no 3169 0.0899186833200973 4419 5723007
SGTC_1077 5-fluorocytosine 377 nM -1.34376194708408 0.0614577160055247 no 3170 0.0895126891464848 4447 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2584 androsterone 48.74 µM -1.34742935106035 0.0609463927246695 no 3171 0.0889209964401291 4316 2754130 A steroid.
SGTC_814 3342-0569 96 µM -1.34853132703415 0.0607934026606135 no 3172 0.0887437756781879 4434 4346283
SGTC_2872 9044037 25.97 µM -1.35702333403826 0.0596244903431064 no 3173 0.0873868982158364 4456 6465195
SGTC_2307 7538926 6.34 µM -1.36122895427936 0.0590521511979126 no 3174 0.0867206733728214 4380 96582
SGTC_3098 9119039 49.47 µM -1.36126325878958 0.0590475005102822 no 3175 0.0867152547438586 4408 17161528
SGTC_2520 obtusaquinone 4.71 µM -1.37324242820254 0.0574409695119499 no 3176 0.0848384968660549 4454 5967872
SGTC_1313 1220-0047 237 µM -1.37559233819595 0.0571298943117637 no 3177 0.0844739400528422 4398 3528706
SGTC_1152 3909-8331 15.9 µM -1.37713398361489 0.0569265365391814 no 3178 0.0842354138048162 4388 16001939
SGTC_480 am 92016 50 µM -1.3805460197306 0.0564784833202357 no 3179 0.0837092952786295 4436 2129 K+ channel blocker.
SGTC_599 1935-0052 86.5 µM -1.38269604754776 0.0561975817513544 no 3180 0.0833790421685158 4409 9557311
SGTC_158 k038-0087 26.446 µM -1.38466286382403 0.0559415826502678 no 3181 0.0830777897216413 4340 X158
SGTC_781 4335-2806 94.4 µM -1.38496183934311 0.0559027489288612 no 3182 0.0830320681350945 4475 845254
SGTC_743 1275-0778 158 µM -1.3866389280131 0.0556853071441193 no 3183 0.0827759458881655 4406 2849257 YMR203W TOM40
SGTC_503 tyrphostin 8 294 µM -1.39120131554394 0.0550971508916771 no 3184 0.0820821942217636 4467 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_997 3996-0078 137 µM -1.39214509582739 0.0549760990930368 no 3185 0.0819392323827901 4474 735687
SGTC_236 1509-0011 5.31 µM -1.39231544408308 0.0549542721743635 no 3186 0.0819134483914112 4465 3107280
SGTC_1134 3477-0009 42.5 µM -1.39524857448511 0.0545795198715888 no 3187 0.0814704468771322 4481 3973534
SGTC_1803 st050068 52.4 µM -1.39583736608499 0.0545045368470728 no 3188 0.0813817376695044 4471 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2768 sulfasalazine 50.2 µM -1.39841975883596 0.0541766291460563 no 3189 0.0809935265584648 4415 5384001 An antioxidant and salicylic acid derivative.
SGTC_2354 9060492 162 µM -1.41029142175924 0.0526892257265537 no 3190 0.0792268252198064 4460 6471895
SGTC_2951 9072950 58.06 µM -1.41127065902684 0.052567997872417 no 3191 0.0790824112587999 4366 16488155
SGTC_1993 st073995 70.8 µM -1.41534549839751 0.0520659154429469 no 3192 0.0784836105113138 4453 3098394
SGTC_2109 5483026 200 µM -1.42223468269027 0.0512257350948233 no 3193 0.0774790667220215 4455 759335
SGTC_1859 st055998 20 µM -1.4251365968822 0.0508750726337614 no 3194 0.0770588597875556 4381 676301
SGTC_1441 4106-0040 13 µM -1.42636245986658 0.0507275167495687 no 3195 0.0768818719484443 4481 2904180
SGTC_723 4182-0001 115 µM -1.43147398569014 0.0501159174513112 no 3196 0.0761472087274315 4465 744821 YLR208W SEC13
SGTC_1224 0823-0416 294 µM -1.43352765218217 0.0498718556700004 no 3197 0.0758535511573628 4475 3598164
SGTC_1650 st011916 45.8 µM -1.43512809132365 0.0496823143621729 no 3198 0.0756252999767804 4405 242528
SGTC_1117 retinoic acid 1.10837 µM -1.43786486377055 0.0493595283873125 no 3199 0.0752362003971306 4495 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2028 5153890 36.43 µM -1.44218374846375 0.0488535499127743 no 3200 0.0746252719923542 4447 2830968 YPR165W RHO1
SGTC_2600 tangeritin 87.95 µM -1.44351034223123 0.0486989677727184 no 3201 0.074438380609649 4370 68077 A bioactive flavone.
SGTC_3146 9095609 49.47 µM -1.45187509454467 0.0477332450404248 no 3202 0.0732681693665331 4504 17173999
SGTC_2572 astragaloside iv 100 µM -1.45357597722961 0.0475387644701148 no 3203 0.073031950569627 4447 45006101 An anti-inflammatory agent.
SGTC_419 nsc-638432 893 µM -1.45856118709044 0.046972405383535 no 3204 0.0723429614022134 4442 368090
SGTC_995 3931-2021 34.6 µM -1.46137738615526 0.0466548624984841 no 3205 0.0719559515745518 4480 730143
SGTC_1175 0741-0056 27.6 µM -1.46180950669071 0.0466062911653045 no 3206 0.0718967091248392 4538 765927
SGTC_50 0929-0078 56.389 µM -1.46486236946017 0.0462642974051984 no 3207 0.0714792356877592 4320 1377751
SGTC_1581 himbacine 57.9 µM -1.46555189607652 0.0461873335526823 no 3208 0.0713852022144959 4480 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1185 1319-0113 81.3 µM -1.46611524030445 0.0461245303252044 no 3209 0.071308447231011 4535 4672763
SGTC_2688 kanamycin b 96.69 µM -1.47434735916664 0.0452145915083131 no 3210 0.0701940449985244 4465 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_3228 9131799 49.47 µM -1.48311509134172 0.0442613895306129 no 3211 0.0690219175456863 4508 17015818
SGTC_1514 1189-1591 158 µM -1.4831200582347 0.0442608541712329 no 3212 0.06902125784095 4490 767698 YMR146C TIF34
SGTC_1774 st048371 48.465 µM -1.48507470985792 0.0440505757806564 no 3213 0.0687620172911784 4484 4242727
SGTC_1700 st030840 7.9285 µM -1.48979149167994 0.04354646809895 no 3214 0.0681395344866066 4534 5499307
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.49503875409878 0.0429911470713915 no 3215 0.0674521641566043 4499 2374 Ca(2+)-ATPase inhibitor.
SGTC_1020 4335-0961 93.3 µM -1.49516482383699 0.042977875749436 no 3216 0.0674357156939104 4458 669075
SGTC_2455 5377712 9.75 µM -1.50301225903276 0.0421582730923476 no 3217 0.066417941386701 4489 2243908
SGTC_2440 5628896 157.78 µM -1.51707842383432 0.0407208574635226 no 3218 0.0646234425048906 4479 5522048
SGTC_2087 5276107 200 µM -1.51806959770069 0.040621088382769 no 3219 0.0644984272154467 4484 144405
SGTC_264 promethazine 12.5 mM -1.52276368409162 0.0401512848908347 no 3220 0.0639089193450452 4373 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_407 eburnamonine 100 µM -1.52899895663086 0.0395340692067571 no 3221 0.0631323512877217 4362 3195
SGTC_3037 9091026 49.47 µM -1.53111817650169 0.0393260579232506 no 3222 0.0628700941606148 4387 25236398 YIL048W NEO1
SGTC_361 000s-0510 1.45 µM -1.53238798308344 0.039201847762169 no 3223 0.0627133605402873 4405 660
SGTC_2942 9052777 62.25 µM -1.53394963208161 0.0390495281230697 no 3224 0.0625210222212256 4511 6469503
SGTC_1540 guanosine 70.6 µM -1.53761602223941 0.0386938100110504 no 3225 0.0620712637849202 4458 6802 Guanosine is a purine nucleoside
SGTC_1385 3091-4834 14.1 µM -1.54179286128305 0.0382917890090191 no 3226 0.0615619686868671 4500 4072814
SGTC_2006 4011487 200 µM -1.54218893512765 0.0382538443130704 no 3227 0.0615138440531813 4480 45595294
SGTC_3211 9128781 49.47 µM -1.5440331208403 0.0380775710314635 no 3228 0.0612901545483622 4441 17194361
SGTC_3099 9120367 49.47 µM -1.54419378919081 0.0380622452541682 no 3229 0.0612706965036773 4550 24824940
SGTC_2967 9089538 49.85 µM -1.54496221802663 0.037989016195439 no 3230 0.061177701213041 4505 728216
SGTC_1891 st059073 26.2 µM -1.54664313189543 0.0378292306214475 no 3231 0.0609746615043056 4583 688754
SGTC_343 4130-2827 29.8 µM -1.54700846445366 0.0377945752227989 no 3232 0.0609306022900906 4501 1118244
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.54752395085242 0.0377457203287078 no 3233 0.0608684768205673 4539 6708784 An antioxidant flavonoid
SGTC_2058 5236698 133 µM -1.54758626963933 0.0377398175995473 no 3234 0.0608609696323288 4480 766665
SGTC_2765 myclobutanil 7.74 µM -1.55135700380115 0.0373840597387088 no 3235 0.0604080765303889 4529 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2047 4141938 200 µM -1.55664777804118 0.0368895133596543 no 3236 0.0597770668051122 4544 3807862
SGTC_99 0109-0120 622.8 µM -1.55958349798762 0.0366174174247646 no 3237 0.0594291693358262 4533 759414
SGTC_2945 9067681 61.76 µM -1.5633312648979 0.036272445399869 no 3238 0.0589873490605243 4557 16456930
SGTC_2370 9071495 200 µM -1.57126689679763 0.0355507699043135 no 3239 0.0580603335028857 4542 21791103
SGTC_2992 9074591 71.4286 µM -1.57361501795386 0.0353395001037435 no 3240 0.0577882395824926 4471 17741321
SGTC_2496 diffractaic acid 79.83 µM -1.57745407923492 0.0349963033071752 no 3241 0.0573455401854173 4523 94870 An apoptosis inducer which activates caspases.
SGTC_745 0469-0705 296 µM -1.5782100557073 0.0349290454236849 no 3242 0.0572586804361742 4558 3486736
SGTC_1206 3978-0017 132 µM -1.58734824332426 0.0341243988381108 no 3243 0.0562168972360885 4566 3873677
SGTC_2170 morpholine 200 µM -1.59093357146716 0.0338128904679515 no 3244 0.0558122631558768 4576 121171 Reacts with secondary amines.
SGTC_1712 st032288 53.4 µM -1.5969112204718 0.0332987312892181 no 3245 0.055142749149941 4339 2883011
SGTC_541 4513-1321 94 µM -1.60148384164456 0.0329097849570229 no 3246 0.0546348980307298 4516 747515
SGTC_3053 9095903 49.47 µM -1.608274659808 0.0323390756164337 no 3247 0.0538875189716807 4644 17174018
SGTC_3256 9138902 49.47 µM -1.61162155830923 0.0320608166801166 no 3248 0.053522158255772 4653 17228773
SGTC_2110 5483698 200 µM -1.62566427781463 0.0309147783776949 no 3249 0.0520105465956856 4544 2848765 YHR062C RPP1
SGTC_2990 9074105 71.4286 µM -1.6257647125577 0.0309067055636399 no 3250 0.0519998588710615 4496 6502001
SGTC_101 0490-5701 117.494 µM -1.62869815128271 0.0306716881795995 no 3251 0.0516884671629567 4433 4661669
SGTC_832 4083-0019 164 µM -1.63065613731423 0.030515645848042 no 3252 0.0514814483603507 4609 1990758
SGTC_2142 5622915 118.518 µM -1.64868684470917 0.0291093650358707 no 3253 0.0496059033100726 4583 5322196
SGTC_1458 k015-0034 6.33 µM -1.65037119181069 0.0289807919484937 no 3254 0.0494335197542113 4593 3598957
SGTC_834 0312-0008 75.7 µM -1.65817016930978 0.0283916008104765 no 3255 0.0486415620078215 4602 6385573 YIL048W NEO1
SGTC_2120 5538279 151.968 µM -1.6598765300733 0.0282640278266827 no 3256 0.0484696469310547 4569 2058197
SGTC_1999 st074831 12.5 µM -1.66139119231409 0.0281511869100156 no 3257 0.0483174527862839 4555 17112523
SGTC_767 0929-0023 86 µM -1.66768455923315 0.0276863461643738 no 3258 0.0476891810922726 4598 1204563
SGTC_2319 6033012 152.6 µM -1.67281107389623 0.0273124351652047 no 3259 0.0471822470775642 4520 847246
SGTC_499 genistein 192 µM -1.67516675090791 0.0271420375284278 no 3260 0.04695075957496 4665 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_555 4296-0685 37 µM -1.68020282006452 0.0267807279479315 no 3261 0.0464589304288443 4568 2908540 YHR072W ERG7
SGTC_2691 st077356 60.2 µM -1.68210000576867 0.026645661141793 no 3262 0.0462747246376847 4555 2839272
SGTC_2088 5278280 127.392 µM -1.68720071993329 0.0262853435822792 no 3263 0.0457823815146342 4609 791502
SGTC_2276 7947513 42.08 µM -1.68725914708055 0.0262812399663056 no 3264 0.0457767663569252 4511 2105100
SGTC_2081 5214970 32.255 µM -1.6883553375703 0.0262043485328718 no 3265 0.0456715192302009 4526 2063512
SGTC_2178 5812956 200 µM -1.69074708079677 0.0260372343210595 no 3266 0.0454425590673372 4563 5403383
SGTC_827 3253-0474 693 µM -1.69889549720923 0.0254745715231306 no 3267 0.0446694377899028 4598 5402065
SGTC_563 tetrahydrosecaminediol 614 µM -1.71414753884367 0.0244487482686651 no 3268 0.0432508164295739 4636 334274 A psychoactive constituent of the cannabis plant.
SGTC_644 1498-1197 63.3 µM -1.71866669876228 0.0241515413377858 no 3269 0.0428375395326591 4638 6741615
SGTC_15 0266-0086 27.098 µM -1.72335975213509 0.02384611638298 no 3270 0.0424117442410214 4659 1712902 YIL048W NEO1
SGTC_2947 9072639 7.68 µM -1.72436031470921 0.0237814211732348 no 3271 0.0423214085586002 4546 16488146
SGTC_2343 7990716 14.84 µM -1.74077295454594 0.0227410872359704 no 3272 0.040861692228652 4613 6456862
SGTC_3012 9080433 71.4286 µM -1.74711160824457 0.0223497023573561 no 3273 0.040308990095533 4587 17688859
SGTC_296 1222-0039 74.9 µM -1.75042016288231 0.0221476801878008 no 3274 0.040022919661896 4625 5984176
SGTC_604 1000-0114 314 µM -1.75301669305533 0.0219902159164586 no 3275 0.0397995708772519 4613 1572745
SGTC_33 0986-0033 35.816 µM -1.7594802619425 0.0216023386601797 no 3276 0.0392479849453783 4607 2848082
SGTC_2757 clomiphene 4.22 µM -1.7620298988814 0.0214509336422981 no 3277 0.0390321230003004 4604 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2832 7992762 51.95 µM -1.76269046334933 0.0214118539927181 no 3278 0.0389763550395142 4532 2985177
SGTC_1701 st028638 40.4 µM -1.77311921311369 0.0208028116716054 no 3279 0.0381044774703566 4619 3490878
SGTC_825 1988-2224 89.6 µM -1.7806461572999 0.0203724049188029 no 3280 0.0374851371323053 4614 1180859
SGTC_3067 9117431 49.47 µM -1.78180696314029 0.020306704003664 no 3281 0.0373903581866575 4620 17150885
SGTC_336 4111-0029 111 µM -1.78295288334681 0.0202420218689862 no 3282 0.0372969867241869 4641 3131175
SGTC_1716 st033144 30.6155 µM -1.811921295935 0.0186639718190264 no 3283 0.0349991791693757 4592 674617
SGTC_1791 st048313 56.1 µM -1.81364595483495 0.0185734190804228 no 3284 0.0348661252992637 4654 1204976
SGTC_850 0388-0143 75.9 µM -1.81416641617911 0.018546165980096 no 3285 0.0348260544432937 4638 67273
SGTC_2424 5537928 59.2 µM -1.83429293171165 0.0175180820577482 no 3286 0.0333052614124918 4635 5382802
SGTC_2556 citropten 84.59 µM -1.84567934319125 0.0169582965787411 no 3287 0.0324693891473097 4616 2775 A potential DNA crosslinker.
SGTC_1613 st002381 52.1 µM -1.86246358658951 0.0161610615231435 no 3288 0.0312688867504315 4641 551167
SGTC_2290 7904846 200 µM -1.86732802502975 0.0159360946278358 no 3289 0.0309278970455104 4668 2962154
SGTC_1760 st045453 10.4495 µM -1.87693545557187 0.0154996566473702 no 3290 0.0302634703434329 4651 3323419 YIL048W NEO1
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.87774568392743 0.0154633239210607 no 3291 0.0302079819508183 4662 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_251 melphalan 456.522 µM -1.88088037306355 0.0153234441781882 no 3292 0.0299940968277333 4680 460612 A DNA alkylator.
SGTC_2079 5212404 121 µM -1.88649888337739 0.0150754468259402 no 3293 0.0296138793686062 4615 758462
SGTC_1865 st057639 52.2 µM -1.89165412951382 0.0148509398079082 no 3294 0.0292685393717117 4664 688818
SGTC_2265 7929201 200 µM -1.90634789969834 0.0142267470724451 no 3295 0.0283025417508376 4645 1265108
SGTC_1429 4049-0205 9.46 µM -1.91219168091886 0.0139848581619738 no 3296 0.027925806382472 4702 22774478
SGTC_810 3825-7150 143 µM -1.91450979892377 0.0138898921297529 no 3297 0.0277775241452075 4654 22330411 YGL099W LSG1
SGTC_1704 st028805 70.8 µM -1.91454288639301 0.0138885406748404 no 3298 0.0277754124088096 4687 2876101
SGTC_112 phenothiazine 287.218 µM -1.925230340764 0.0134579034576182 no 3299 0.0271002739532583 4636 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1464 k208-0027 110 µM -1.92652435472622 0.0134065535633962 no 3300 0.0270194669091336 4652 X1464
SGTC_2700 st077718 96.8 µM -1.95160203466706 0.0124442984786677 no 3301 0.0254927357490619 4643 904970
SGTC_510 ag-490 170 µM -1.95582886508744 0.012288144072173 no 3302 0.0252426586626833 4753 5328779
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.97522411832591 0.0115931901565599 no 3303 0.0241213600294625 4616 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_3223 9129970 49.47 µM -1.98696957668727 0.011189142714507 no 3304 0.0234628841827138 4674 17248386
SGTC_1323 1348-1351 11.2 µM -1.9871209288933 0.0111840170764609 no 3305 0.0234544987444432 4672 6989654
SGTC_1463 k081-0032 34.1 µM -1.98826819424862 0.0111452305532455 no 3306 0.0233910182152992 4197 977755
SGTC_924 2046-0044 21.3 µM -2.00726674974791 0.0105197306583621 no 3307 0.0223606337878004 4662 3623589
SGTC_2929 9013348 24.6 µM -2.01022125943018 0.0104252579934082 no 3308 0.0222038881546234 4655 2995952
SGTC_353 1988-1175 58.3 µM -2.01903961323372 0.0101476684200963 no 3309 0.0217415511982883 4537 2788357
SGTC_2956 9076196 2.52 µM -2.04535951308951 0.0093571457591969 no 3310 0.0204097136944481 4686 16423868
SGTC_1210 3013-0140 750 nM -2.05821066810139 0.00899112347536857 no 3311 0.0197849574930649 4722 905973
SGTC_1570 verbenone 133 µM -2.07216064434358 0.00860805867918332 no 3312 0.0191252311435491 4693 29025 A natural terpanoid with antifungal properties.
SGTC_2062 5245942 200 µM -2.0840424577303 0.0082931521975433 no 3313 0.0185781527090988 4724 1376160
SGTC_2864 9034755 47.6 µM -2.0940827130972 0.00803498592377999 no 3314 0.0181263063619211 4670 4930451
SGTC_2762 leflunomide 42.06 µM -2.09521119528526 0.00800641547497182 no 3315 0.0180761112561376 4667 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_704 1310-0270 142 µM -2.09597310283806 0.00798717635526645 no 3316 0.0180422885096964 4690 5718033
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -2.11952032386776 0.00741227921054779 no 3317 0.0170232590095259 4619 4330530
SGTC_441 propafenone 146 µM -2.12645601399479 0.00725004939995259 no 3318 0.0167326540100955 4711 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_148 3253-0744 288.01 µM -2.14076732519576 0.00692516392846837 no 3319 0.0161464030839374 4641 6893655
SGTC_1526 st051518 75 µM -2.14788188244142 0.00676849036555658 no 3320 0.0158615700016891 4690 673993
SGTC_1436 4092-1007 8.32 µM -2.15673452982599 0.00657791974847657 no 3321 0.015513177454334 4730 2881121
SGTC_2759 disulfiram 3.38 µM -2.16787702411123 0.00634480961530417 no 3322 0.0150840222066554 4636 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2679 rapamycin 1 nM -2.21081196227957 0.00551350754726644 no 3323 0.013524430560793 4586 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1011 4112-3381 17.4 µM -2.25815985064611 0.00471024269867882 no 3324 0.0119678476800136 4738 2877139
SGTC_2619 obliquin 87.91 µM -2.2640234831042 0.00461840643578015 no 3325 0.0117863352458266 4721 6708593 A bioactive alkalod. YER133W GLC7
SGTC_3352 9151559 45.5865 µM -2.27323776098175 0.00447731839963328 no 3326 0.0115059279456526 4742 17159339
SGTC_649 1123-0311 367 µM -2.27609479240309 0.00443436048478771 no 3327 0.0114201683526557 4654 693629 YIL048W NEO1
SGTC_2589 lobaric acid 100 µM -2.33395657587715 0.00364003613565375 no 3328 0.00979899791005012 4684 73157 A novel microtubule depolymerizer.
SGTC_341 1486-1430 230 µM -2.36814666787895 0.00323309139036541 no 3329 0.00893872362967898 4727 2054753 YPL210C SRP72
SGTC_2066 5222451 176 µM -2.37693746531586 0.00313530288182159 no 3330 0.00872852369447947 4714 2281147
SGTC_1440 4100-1550 40 µM -2.45358809410328 0.00238910798298405 no 3331 0.00707194453609207 4765 742806
SGTC_804 1595-0054 20.9 µM -2.47216364968519 0.00223438658026133 no 3332 0.00671490115338103 4762 761523 Stimulates phospholipase C.
SGTC_2830 7992007 71.43 µM -2.4748383532364 0.00221287197978627 no 3333 0.00666482458400587 4705 1952075
SGTC_1800 st050079 29.0735 µM -2.53857747738052 0.00175263374268769 no 3334 0.00556520775142557 4664 3645560
SGTC_2601 securinine 100 µM -2.55301198315645 0.00166133435589842 no 3335 0.00533979109439136 4742 442872 A GABA receptor antagonist.
SGTC_620 0109-0052 432 µM -2.579314895897 0.00150602660303012 no 3336 0.00494982491249242 4775 493037
SGTC_516 3992-2719 87.3 µM -2.58359299994568 0.00148205688616368 no 3337 0.00488885510670344 4720 5350887 YDR037W KRS1
SGTC_2996 9066192 71.4286 µM -2.59560438622265 0.00141660728433251 no 3338 0.00472123579487562 4742 6472854
SGTC_1818 st052136 56.3 µM -2.59594770715048 0.00141477594915979 no 3339 0.00471652102309502 4571 674169
SGTC_808 0711-0032 135 µM -2.64772917368066 0.00116206417927652 no 3340 0.00405172071038779 4763 4252555
SGTC_454 lyso-paf C-16 6.67 µM -2.66416567766178 0.00109094604925075 no 3341 0.00385897702681691 4762 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_623 k072-0108 16.9 µM -2.70546480950185 0.000929498395707498 yes 3342 0.00341044373759846 4779 5382803
SGTC_1573 oleylamine 1.06 µM -2.72211418257366 0.000870861026941227 yes 3343 0.00324328630078241 4765 5356789 An amine of the fatty acid oleic acid.
SGTC_3350 9150499 3.57 µM -2.72903563839502 0.000847500951285727 yes 3344 0.00317599194220219 4779 4910996 YPR165W RHO1
SGTC_1754 st042065 16.137 µM -2.7506686706381 0.000778154515769175 yes 3345 0.00297368822447786 4654 1126236 YIL048W NEO1
SGTC_1769 st044406 64.4 µM -2.83854742334376 0.00054684660938206 yes 3346 0.00226596922520672 4791 670903
SGTC_2628 lathosterol 100 µM -2.84294108034312 0.000537151179211151 yes 3347 0.00223496664635113 4774 6710616
SGTC_624 k048-0052 28 µM -2.92388704731767 0.000384677535110268 yes 3348 0.00172845080672055 4789 6835531
SGTC_3046 9092212 49.47 µM -3.04738604862604 0.000227523349038225 yes 3349 0.00115420515565142 4799 25236637
SGTC_2626 ethyl orsellinate 100 µM -3.05375727860057 0.000221327381243895 yes 3350 0.00112997423340571 4770 75653 A natural product.
SGTC_1713 st033146 12.748 µM -3.05516049924441 0.000219984093255147 yes 3351 0.00112470055593427 4775 674619
SGTC_1479 0549-0158 134 µM -3.14820475606087 0.000146113331282042 yes 3352 0.000821382896228578 4808 5440202
SGTC_2165 5727197 32.143 µM -3.3341698538815 6.24250739607716e-05 yes 3353 0.000427771982330518 4785 1361712
SGTC_2250 alverine citrate 130 µM -3.3780510055276 5.07515603770671e-05 yes 3354 0.000365007694080794 4736 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1462 k081-0014 26.5 µM -3.72021252977485 9.29114745356058e-06 yes 3355 9.95275998233821e-05 4513 3270634
SGTC_2253 7938677 135.83 µM -4.08755095063388 1.27182255473585e-06 yes 3356 2.1797547595487e-05 4808 2301972