SGTCid condition conc unit QRI7|YDL104C.score QRI7|YDL104C.strain.pval QRI7|YDL104C.strain.significant QRI7|YDL104C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_3029 9088683 49.47 µM 5.23000257578639 4.02407077928284e-08 yes 1 8.47538389647262e-08 9 25236615
SGTC_773 4358-1457 44.6 µM 4.58210875920455 1.32774182487646e-06 yes 2 2.30155184874802e-06 27 1186886
SGTC_2794 7785382 27.27 µM 4.26933101715165 6.14860709218365e-06 yes 3 9.80300603911992e-06 26 2205081
SGTC_1630 st005209 31.3 µM 4.16904563519286 9.83925566697628e-06 yes 4 1.52938872991082e-05 20 3367314
SGTC_1627 st003713 25.6 µM 4.1666079439125 9.9510688185908e-06 yes 5 1.545827659972e-05 64 16195070 YER133W GLC7
SGTC_2411 st077133 39.94 µM 4.11014031989292 1.29065008547012e-05 yes 6 1.97709378966036e-05 27 1403142 YNL221C POP1
SGTC_3137 9097352 49.47 µM 4.02806768031532 1.87254007363729e-05 yes 7 2.81185781603016e-05 39 44120435
SGTC_1129 3453-1384 223 µM 3.97890338627034 2.33246807832899e-05 yes 8 3.46169329468062e-05 39 1084452
SGTC_1137 ixabepilone 100 µM 3.83873000099015 4.30412513242224e-05 yes 9 6.18361667193698e-05 28 154225 A novel microtubule stabilizer.
SGTC_1838 st055369 84.5 µM 3.7107339487591 7.40024015198164e-05 yes 10 0.000103329605004129 25 676036
SGTC_1406 3909-7906 11.9 µM 3.70390627451995 7.61372808143454e-05 yes 11 0.000106152362912925 13 X1406
SGTC_1830 st055982 50.3 µM 3.56022696435142 0.000137010452744963 yes 12 0.000185267199705326 32 455313 An antimicrobial agent.
SGTC_2519 cryptotanshinone 88.04 µM 3.43471505884621 0.000225017940161602 yes 13 0.000296588594139157 26 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2687 chenodiol 100 µM 3.42419540992158 0.000234402377217126 yes 14 0.000308311323017871 40 5702181 A cholesterol synthesis inhibitor.
SGTC_966 1300-0360 30.2 µM 3.35644938196056 0.000304142251802879 yes 15 0.000394750856899384 47 70588
SGTC_2405 ticlatone 3.52 µM 3.35534582059892 0.000305423697322052 yes 16 0.000396329136609682 97 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_236 1509-0011 5.31 µM 3.33849195273668 0.00032562913889311 yes 17 0.000421172350834402 434 3107280
SGTC_1288 0973-0013 65.5 µM 3.32627901621741 0.000341040085093723 yes 18 0.000440068890065329 38 4315430
SGTC_1352 1496-0991 99 µM 3.29711582206908 0.000380623686944097 yes 19 0.000488416049066657 48 3000039
SGTC_2365 9042475 200 µM 3.28233117828153 0.000402282485488605 yes 20 0.000514763062023372 74 6464479
SGTC_619 1652-1634 108 µM 3.26269489469306 0.000432818861525758 yes 21 0.000551791307003365 45 5400454
SGTC_1674 st016616 23.6 µM 3.24326482062423 0.000465138122037725 yes 22 0.000590841607154619 58 625830
SGTC_706 4262-0057 46.9 µM 3.20847316547389 0.000528656129232773 yes 23 0.0006672088056321 72 883298
SGTC_23 0213-0011 39.996 µM 3.13170551571857 0.000698185025540804 yes 24 0.000868970506704429 51 627608
SGTC_1840 st055363 71 µM 3.08214269725572 0.000832911086095577 yes 25 0.00102758145784478 47 676033
SGTC_3326 9140064 16.379 µM 3.05077413554645 0.000930134989672042 yes 26 0.00114126103809749 53 1868434
SGTC_335 4077-0256 27.6 µM 3.02481464007196 0.00101836357369741 no 27 0.00124392774146077 46 3121989
SGTC_3217 9129673 49.47 µM 3.02414639641285 0.00102073291044972 no 28 0.00124667876566966 92 17248312
SGTC_2415 st077333 57.7 µM 3.00400162252451 0.00109457711355691 no 29 0.0013322695200748 113 2766255
SGTC_310 1273-0058 1.06 µM 3.00333028347482 0.00109712029394573 no 30 0.00133521223128971 348 2734232
SGTC_2764 methyldopa 94.69 µM 2.98210146230641 0.00118038749959222 no 31 0.00143138552803894 72 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_487 nimodipine 119 µM 2.95116244813137 0.00131213304453503 no 32 0.00158290183370588 27 4497 L-type voltage-gated calcium channels inhibitor
SGTC_15 0266-0086 27.098 µM 2.94739160626617 0.00132907767682801 no 33 0.00160233540594271 128 1712902 YIL048W NEO1
SGTC_3007 9078383 71.4286 µM 2.90337096329769 0.00154222994535932 no 34 0.00184584533037619 64 6496995
SGTC_347 4534-1311 26.2 µM 2.86682161208927 0.00174240395920201 no 35 0.00207308322673861 60 2862016
SGTC_2322 7413319 38.22 µM 2.86358779578904 0.00176120715144508 no 36 0.00209436357109057 251 1840400
SGTC_2514 salinomycin 42.74 µM 2.83695608321926 0.00192322092110518 no 37 0.00227729381546203 120 23682228 A polyether potassium ionophore.
SGTC_3344 9148862 3.898 µM 2.78559446434141 0.00227444678533464 no 38 0.00267148347341506 70 4905352
SGTC_2517 totarol 10 µM 2.78222604266354 0.00229939524526339 no 39 0.00269937118305342 78 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_895 0964-0006 13.7 µM 2.72887250559675 0.00272903202093705 no 40 0.00317756344269812 68 6738897
SGTC_2079 5212404 121 µM 2.67803990035239 0.00320445211058185 no 41 0.00370271980136579 62 758462
SGTC_2814 7977482 42.97 µM 2.65726388536253 0.00341933312915235 no 42 0.00393888761557371 150 6456762
SGTC_1554 st069299 38.7 µM 2.65041784006791 0.00349292537388723 no 43 0.00401961388489354 91 24207999
SGTC_181 1447-1644 8.07 µM 2.63492194902654 0.00366477915643543 no 44 0.00420783161297374 109 534600
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 2.63015192312816 0.00371918642317951 no 45 0.0042673359227019 92 4330530
SGTC_1996 st072960 66.8 µM 2.61279781929653 0.00392329308449086 no 46 0.00449022053200107 83 1719405
SGTC_1434 4073-0095 163 µM 2.61089788370665 0.00394623737724374 no 47 0.00451524272140205 69 24133745
SGTC_1006 4099-6547 255 µM 2.58409344173199 0.00428299220340282 no 48 0.0048817669174605 120 3146833
SGTC_1678 st019265 80.2 µM 2.57334884327678 0.00442504065259162 no 49 0.00503598160648074 118 5367020
SGTC_3319 9138450 16.7555 µM 2.56205487892941 0.00457887486710589 no 50 0.00520274374917694 96 2029690
SGTC_1829 berberine 14.4 µM 2.56055204900266 0.00459970063536725 no 51 0.00522530038964846 89 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2681 menadione 3.18 µM 2.5576756491664 0.00463979681003451 no 52 0.00526871631284628 103 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_835 0312-0010 67.2 µM 2.54981766146258 0.00475092931134427 no 53 0.00538896362041655 80 1626196
SGTC_2083 5306046 65.942 µM 2.54403049336874 0.00483428661941088 no 54 0.00547907589095765 141 539837
SGTC_929 2805-0021 398 µM 2.54260022596979 0.00485508780959769 no 55 0.00550155198194829 104 3098024
SGTC_511 blebbistatin 171 µM 2.54242877923393 0.00485758660384905 no 56 0.00550425169128951 104 3476986 A myosin inhibitor.
SGTC_3136 9095672 49.47 µM 2.51998572001352 0.00519475342305966 no 57 0.0058679797684304 110 17217380
SGTC_2453 5731132 22.18 µM 2.50252215799909 0.00547135646012722 no 58 0.00616559531469801 126 1362040
SGTC_3320 9137005 35.139 µM 2.4865962473841 0.00573493524531474 no 59 0.00644858388613871 108 4908713
SGTC_1889 st059080 5.18 µM 2.48630346119179 0.00573988467553288 no 60 0.00645389227126645 120 176925 Isolated from Daphnopsis sellowiana.
SGTC_1329 1447-1697 50.6 µM 2.46678843318124 0.00607844672691146 no 61 0.0068165440621998 114 2840515
SGTC_3327 9140648 26.9345 µM 2.44264494161809 0.00652171757959176 no 62 0.00729003682890204 85 8029710
SGTC_2009 4012297 12.05 µM 2.43122238467726 0.00674122385245198 no 63 0.00752398762829944 162 45595307
SGTC_1187 1391-0724 117 µM 2.42486746547265 0.00686615096792426 no 64 0.0076569881558922 119 6997986
SGTC_1377 2944-0135 198 µM 2.42188356507381 0.00692551168702314 no 65 0.00772014842264737 161 1894137
SGTC_1111 tnp00062 510.699 nM 2.40755960733307 0.00721682085955434 no 66 0.00802977016812184 109 676306
SGTC_1621 st003705 32.4 µM 2.37492592653778 0.00792117737925544 no 67 0.00877623611763371 157 24207032
SGTC_291 SEC14.278 35.5 µM 2.36790442900974 0.00808040167100195 no 68 0.00894457814539749 107 1068044
SGTC_2771 fluoxetine 41.05 µM 2.36106109846377 0.008238285705009 no 69 0.00911136403118582 126 3386 A selective serotonin reuptake inhibitor.
SGTC_2358 9037157 4 µM 2.35181839292065 0.00845582456784494 no 70 0.00934094676586919 152 2388925
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 2.33036640264608 0.00898025387326902 no 71 0.00989339695715508 103 61125 An anti-inflammatory.
SGTC_3103 9120822 49.47 µM 2.33029849137229 0.00898195833047607 no 72 0.00989519022374429 124 17141819
SGTC_2697 mebhydrolin 72.4 µM 2.31594761121046 0.00934855924476846 no 73 0.0102805646492549 221 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2786 7743617 45.45 µM 2.31580932144962 0.00935215468790902 no 74 0.0102843410302222 139 583674
SGTC_2888 9058547 12.99 µM 2.30538618132243 0.00962665489516557 no 75 0.0105724773638692 107 16476514
SGTC_2690 usnic acid 100 µM 2.30258749383543 0.00970154894220411 no 76 0.010651031736549 171 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_496 calpeptin 138 µM 2.28565522756261 0.0101656119107596 no 77 0.0111372182435159 138 73364 A calpain inhibitor.
SGTC_979 1426-2828 121 µM 2.28537847690253 0.0101733549558354 no 78 0.0111453224625628 167 747872
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 2.27853080929295 0.010366587273213 no 79 0.0113474855163273 162 5393153
SGTC_2441 5730946 39.09 µM 2.27248144343272 0.0105399465656508 no 80 0.0115287237729697 160 1774275
SGTC_678 1218-2179 85.9 µM 2.26658330754588 0.0107113984841648 no 81 0.0117078463770224 75 6820081 YOR116C RPO31
SGTC_2490 carminic acid 95.39 µM 2.26622038800781 0.0107220269972358 no 82 0.0117189464754229 89 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_415 dibenzyl ketone 100 µM 2.26401528268539 0.0107868036425374 no 83 0.0117865874174978 131 7593
SGTC_1416 3966-0321 25.3 µM 2.26379946865952 0.0107931616092705 no 84 0.0117932256133492 156 582530 YLR208W SEC13
SGTC_2313 7726885 200 µM 2.25646953176659 0.0110110502515152 no 85 0.0120206206761469 175 726423
SGTC_2306 7482397 179.52 µM 2.24233835828025 0.0114419296786141 no 86 0.0124697562162063 153 891448
SGTC_1998 st075797 76.8 µM 2.23247501772262 0.0117512890461308 no 87 0.0127917922838497 178 24208315
SGTC_212 3807-4682 38.772 µM 2.23144239667025 0.0117840927061016 no 88 0.0128259195742206 265 3125501 YBL034C STU1
SGTC_3156 9099931 49.47 µM 2.22550491121437 0.0119742572628791 no 89 0.0130236809000026 148 18111053
SGTC_1545 lovastatin 49.4 µM 2.21684690420072 0.0122563220010284 no 90 0.0133167775401513 203 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2766 oltipraz 83.91 µM 2.21244674738237 0.0124018661865651 no 91 0.0134679059384088 170 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2913 7966556 36.57 µM 2.20299771372166 0.0127194789497868 no 92 0.0137974548920173 130 2976516
SGTC_2388 9080168 200 µM 2.19416834954688 0.0130225993437674 no 93 0.0141116545162329 123 15943073
SGTC_3084 9116877 49.47 µM 2.19325594817425 0.0130542760797713 no 94 0.0141444717926851 100 27241325
SGTC_180 1486-1293 102.781 µM 2.18778576780122 0.0132455898253055 no 95 0.0143426055327887 196 4140536
SGTC_2621 lithochol-11-enic acid 100 µM 2.17966508586818 0.0135340673571474 no 96 0.0146411482006742 218 6708711
SGTC_1248 0469-0687 58.6 µM 2.161094616537 0.0142142110323812 no 97 0.0153440156763124 191 4017482
SGTC_2713 st079149 53.4 µM 2.15719532634109 0.0143607046153148 no 98 0.0154952242395544 198 3103253
SGTC_3219 9131112 49.47 µM 2.14311239122761 0.0149006679518543 no 99 0.0160520373565511 185 17612988 YMR079W SEC14
SGTC_772 k072-0172 35.3 µM 2.1360774747795 0.0151768750075649 no 100 0.0163365497169998 168 5861980
SGTC_1289 0976-0073 69.1 µM 2.13217709646344 0.0153318998762221 no 101 0.0164961452850956 164 3391136
SGTC_2635 hydroquinidine 100 µM 2.12745960866821 0.0155212169193349 no 102 0.016690956961213 169 442912 An experimental heart treatment.
SGTC_2353 9059630 146.67 µM 2.12271851078364 0.0157134994680545 no 103 0.0168887234555117 135 4779114
SGTC_2144 5628481 200 µM 2.12229049483644 0.0157309584535262 no 104 0.0169066755944011 178 2818399
SGTC_571 k831-0106 44.2 µM 2.11914255188915 0.0158598765934424 no 105 0.0170392107731983 171 4783639
SGTC_2798 7813637 45.45 µM 2.11332072469565 0.0161006866709385 no 106 0.0172866630266189 199 956368
SGTC_667 1498-1044 59 µM 2.11265965454686 0.0161282277985401 no 107 0.0173149544222932 193 6739982
SGTC_506 n9-isopropylolomoucine 153 µM 2.10017546097043 0.0166559666874615 no 108 0.0178567045800562 178 6610355
SGTC_623 k072-0108 16.9 µM 2.09194991942052 0.0170116989172688 no 109 0.0182214979371239 197 5382803
SGTC_1607 st000305 50.6 µM 2.09160830408127 0.0170266122568215 no 110 0.0182367845416245 180 5457690
SGTC_1114 scopoletin 1.73284 µM 2.08106888540952 0.0174922365820272 no 111 0.0187138006614987 172 5280460 A coumarin with genotoxic properties.
SGTC_392 N-ethylmaleimide 8.33 µM 2.07786836009516 0.0176357680993848 no 112 0.0188607427047037 179 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 2.07288143001382 0.017861416004085 no 113 0.0190916578257255 88 1241132 A phosphatase inhibitor.
SGTC_2992 9074591 71.4286 µM 2.06775100598656 0.0180961219678403 no 114 0.0193317214623294 153 17741321
SGTC_1117 retinoic acid 1.10837 µM 2.06294786503308 0.018318233165385 no 115 0.0195587908875629 200 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_222 nsc-310342 10.666 µM 2.06117793630996 0.0184006633759935 no 116 0.0196430338255372 102 432556
SGTC_2080 5212524 12.4 µM 2.05582635669889 0.0186518248251189 no 117 0.0198996282791862 160 260183
SGTC_930 2810-3379 265 µM 2.05268590157118 0.01880056760472 no 118 0.020051525130617 222 1015764
SGTC_2749 bexarotene 57.39 µM 2.04729836495454 0.0190580909973506 no 119 0.0203143991746955 247 82146 An retinoic acid receptor inhibitor.
SGTC_2370 9071495 200 µM 2.04656137926737 0.0190935509499336 no 120 0.0203505850573164 224 21791103
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 2.03734544956429 0.0195417315896408 no 121 0.0208077181434259 188 688798
SGTC_2360 9040895 200 µM 2.03633235183695 0.0195915403667335 no 122 0.0208584966527632 196 4914414
SGTC_1158 4092-0494 91.8 µM 2.03456339313918 0.0196787693962462 no 123 0.0209474119501573 196 1148199
SGTC_1547 harmine 94.2 µM 2.03179489360045 0.0198159484982698 no 124 0.0210872121868299 281 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1925 st057770 10.1 µM 2.02258457172859 0.0202781754173107 no 125 0.0215579980878658 205 5989122
SGTC_3225 9130819 49.47 µM 2.02230217727916 0.02029249081598 no 126 0.0215725719218211 211 4547121
SGTC_1363 1636-0063 10.4 µM 2.01952124879099 0.0204339223493757 no 127 0.0217165355267548 232 6072185
SGTC_1109 tnp00067 928.257 nM 2.0155432062971 0.0206376878192165 no 128 0.0219238818570319 186 676295
SGTC_2700 st077718 96.8 µM 2.01473762747324 0.0206791604978549 no 129 0.0219660737104131 153 904970
SGTC_1757 st041620 31.8375 µM 1.99560985985544 0.021684825569799 no 130 0.0229882027292797 225 5289815
SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.994361445143 0.0217518747754813 no 131 0.0230562843696578 122 77254
SGTC_3198 9112019 49.47 µM 1.99152227523203 0.0219050116841083 no 132 0.0232117494028589 199 45595555
SGTC_248 streptozotocin 5.23457 mM 1.98966991519351 0.0220054127693757 no 133 0.0233136544311905 240 5300 DNA alkylating agent.
SGTC_1005 4092-0690 4.4 µM 1.98699975401789 0.0221508235218987 no 134 0.0234612120524217 223 1529343
SGTC_702 1488-0190 94 µM 1.98502964770843 0.0222586300677976 no 135 0.0235705865259698 184 949357
SGTC_2094 5332512 191.667 µM 1.96922025104489 0.0231398721986609 no 136 0.0244639021813713 258 755774
SGTC_2375 9072683 200 µM 1.96218472600943 0.0235413884604863 no 137 0.0248704907700385 257 16798029
SGTC_1003 4049-0218 100 µM 1.94557727463062 0.0245124673238155 no 138 0.0258527695092918 275 295161
SGTC_1831 st055328 12 µM 1.943680797801 0.0246254680715508 no 139 0.02596697781031 249 1103068
SGTC_1445 4239-0156 97.7 µM 1.9394982966962 0.0248762262070569 no 140 0.026220345866129 275 4008346
SGTC_276 colchicine 750 µM 1.93320259796556 0.0252577144133678 no 141 0.0266056224276739 251 2833 A microtubule depolymerizer.
SGTC_1854 st056233 32.9 µM 1.92690893005323 0.0256439669584915 no 142 0.0269954902060935 229 5393174
SGTC_1878 temozolomide 1 mM 1.91880930650628 0.0261483192500774 no 143 0.0275042358170321 190 5394 DNA alkylating agent.
SGTC_107 0358-0022 2.6945 µM 1.91100270464143 0.0266422492519425 no 144 0.0280021166619893 155 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_961 1252-1571 372 µM 1.90562965108831 0.0269867152601163 no 145 0.028349136165647 263 6813498
SGTC_1591 genipin 88.4 µM 1.90433215206327 0.0270704527518732 no 146 0.028433469684268 212 442424 A DNA cross-linking agent.
SGTC_640 3381-0960 37.1 µM 1.89706569306182 0.0275434297605095 no 147 0.0289096341922713 249 1745025
SGTC_457 grayanotoxin iii 135 µM 1.8883808452354 0.0281177478817541 no 148 0.0294874204783086 368 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.88116585730506 0.028602416670461 no 149 0.0299746803062416 206 616764
SGTC_1435 4092-0789 56.7 µM 1.88094510069971 0.0286173549316815 no 150 0.0299896936197659 232 2248285
SGTC_538 2922-0838 53.3 µM 1.87860396491303 0.0287761756682885 no 151 0.0301492946863436 318 777039
SGTC_2275 7947463 200 µM 1.8767872145034 0.0288999269327912 no 152 0.0302736317515149 225 1225414
SGTC_2678 equilin 100 µM 1.87633599998388 0.0289307307138712 no 153 0.0303045783359262 265 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_896 0964-0007 44.5 µM 1.87577505721422 0.0289690635338816 no 154 0.0303430871908198 217 6756758
SGTC_2055 5235184 200 µM 1.87219678724127 0.0292145843353345 no 155 0.0305896917067438 267 2836034
SGTC_155 k072-0202 43.6 µM 1.86439742477479 0.029755725607959 no 156 0.031132957133205 224 5857737
SGTC_1508 1080-0625 72.9 µM 1.86311178758272 0.0298457201477488 no 157 0.0312232700745227 229 767111
SGTC_2824 7998404 51.95 µM 1.85634310334249 0.0303232588519429 no 158 0.0317023344911872 245 837851
SGTC_3229 9132204 49.47 µM 1.85558780844983 0.0303769363294107 no 159 0.0317561663733801 175 17682924
SGTC_3163 9099914 49.47 µM 1.85054095823571 0.0307376311439082 no 160 0.0321178102108361 152 16268368
SGTC_905 2-aminofluorene 215 µM 1.84793347494013 0.0309253710638673 no 161 0.0323059835944754 290 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2792 7535235 81.82 µM 1.84608352310936 0.0310591430964034 no 162 0.032440039443011 259 1281891
SGTC_446 go6976 132 µM 1.84505844063313 0.0311334738447698 no 163 0.0325145189341328 216 3501 A protein kinase C inhibitor.
SGTC_257 daunorubicin 18.5 µM 1.84286417026889 0.0312930794280876 no 164 0.0326744223788372 211 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1602 st001878 87.6 µM 1.83531190390742 0.0318475922921969 no 165 0.0332297441433826 253 595405 YLR310C CDC25
SGTC_3083 9117465 49.47 µM 1.83420326001701 0.0319296717752181 no 166 0.0333119138517449 291 16420915
SGTC_2986 9022445 71.43 µM 1.83395342207788 0.0319481928617021 no 167 0.0333304542540015 277 6459286
SGTC_871 0574-0004 149 µM 1.83383258572555 0.0319571539336097 no 168 0.0333394245337566 310 9551173
SGTC_873 0591-4978 488 µM 1.82700049012836 0.0324672001832444 no 169 0.0338498478508199 281 3305145
SGTC_342 k048-0088 23.3 µM 1.81888867056427 0.0330814846720498 no 170 0.0344642083248609 276 6820570
SGTC_2968 9090663 33.37 µM 1.81706504109829 0.0332208931578754 no 171 0.0346035774330691 304 25236811
SGTC_1130 3454-2858 15.9 µM 1.81137201109975 0.0336592167491946 no 172 0.0350416427520117 341 715628 YIL048W NEO1
SGTC_1526 st051518 75 µM 1.8041844219309 0.0342193972763984 no 173 0.0356012003119897 269 673993
SGTC_2956 9076196 2.52 µM 1.7997267967667 0.0345706463507996 no 174 0.0359518938556009 294 16423868
SGTC_587 k089-0003 57 µM 1.79586767248574 0.0348771219937932 no 175 0.0362577824514952 159 9659696
SGTC_3312 9133330 71.43 µM 1.78743471297486 0.0355545979821899 no 176 0.0369336276647674 265 17617324
SGTC_990 3985-0011 41.3 µM 1.76882632865746 0.037087736266763 no 177 0.038461430778254 255 5399565 YGL099W LSG1
SGTC_1138 3761-0006 1.03 µM 1.76498152498325 0.0374111493532577 no 178 0.0387834353846725 240 12061087
SGTC_322 k048-0136 19.3 µM 1.7636528102634 0.0375234509171552 no 179 0.0388952253125535 271 6823282
SGTC_143 4032-1194 15.74 µM 1.76125526601338 0.0377267852500595 no 180 0.0390976038954946 404 1806963
SGTC_3037 9091026 49.47 µM 1.76068979239434 0.0377748735859122 no 181 0.0391454606857178 458 25236398 YIL048W NEO1
SGTC_2585 alliin 100 µM 1.76045638288991 0.0377947375012214 no 182 0.0391652283426478 327 87310 A garlic compound which reacts with lipids.
SGTC_2426 5582046 32.21 µM 1.75665822800568 0.038119172678449 no 183 0.0394880407903523 326 2251934
SGTC_2243 6634756 200 µM 1.75406125110399 0.0383423090810171 no 184 0.0397100061787129 254 885676
SGTC_1929 genistein trimethyl ether 50.5 µM 1.74196682910815 0.0393955488270765 no 185 0.0407571243654698 310 136420
SGTC_1791 st048313 56.1 µM 1.74044379938026 0.0395298345449129 no 186 0.04089056017864 258 1204976
SGTC_3053 9095903 49.47 µM 1.73966800140393 0.0395983797366181 no 187 0.040958665571199 256 17174018
SGTC_3160 9100216 49.47 µM 1.73076773950384 0.0403916937703471 no 188 0.041746598962526 267 17191039
SGTC_1718 roemerine 11.9335 µM 1.72691840973317 0.0407387737964787 no 189 0.042091158822025 377 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1368 1852-0141 284 µM 1.72609450594753 0.0408133757408104 no 190 0.0421652060426633 320 2838987
SGTC_3310 9130229 44.1445 µM 1.72314251673647 0.0410815797379381 no 191 0.0424313779078177 303 7761258
SGTC_1094 duloxetine 25.4 µM 1.71960322515482 0.0414050254766369 no 192 0.0427522947654012 319 60834 A selective serotonin reuptake inhibitor.
SGTC_3167 9103034 49.47 µM 1.7183046042068 0.0415242190412567 no 193 0.0428705350063438 217 5127859
SGTC_2330 7979373 200 µM 1.71773171808197 0.0415768895371465 no 194 0.0429227805842769 354 1863007
SGTC_1520 flindersine 88 µM 1.71644531560464 0.04169535714362 no 195 0.0430402842978557 331 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_197 4544-0043 41.561 µM 1.7074736791605 0.0425291965282493 no 196 0.0438670229744928 375 896523
SGTC_1796 st049173 110.4 µM 1.70161948309032 0.043080529588696 no 197 0.0444133614074081 240 94134
SGTC_1690 st023502 41.2 µM 1.7005532741795 0.0431815612245463 no 198 0.0445134522985507 288 24207482
SGTC_2829 7992743 58.44 µM 1.69861192267589 0.04336601085523 no 199 0.0446961642578268 352 16462845
SGTC_1186 1319-0216 26 µM 1.69852496302661 0.0433742878353823 no 200 0.0447043626519749 339 4565136
SGTC_207 4185-0010 4.486 µM 1.69819227009997 0.0434059659381191 no 201 0.0447357395033157 408 3761753
SGTC_2777 climbazole 1.536 µM 1.69787312217916 0.0434363718731758 no 202 0.044765855565389 368 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_854 0422-0053 192 µM 1.69489262872416 0.043721160988749 no 203 0.045047895560203 312 3596728
SGTC_3161 9100388 49.47 µM 1.69299116971763 0.0439036331113071 no 204 0.045228574011297 277 25236368
SGTC_1745 st081495 74 µM 1.68921534686318 0.0442677979429407 no 205 0.0455890845064666 414 13842402 YBL026W LSM2
SGTC_2265 7929201 200 µM 1.68760691810937 0.0444236628822337 no 206 0.0457433551741883 333 1265108
SGTC_3202 9113761 49.47 µM 1.67644253868864 0.0455177717227858 no 207 0.0468257712766121 426 4798415
SGTC_2622 2-methoxyxanthone 59.94 µM 1.67142725353665 0.0460162725687886 no 208 0.0473186582554042 326 71034 A hepatoprotective.
SGTC_1649 st011737 51.3 µM 1.6603669620989 0.047131127942121 no 209 0.0484203261228056 329 1761035
SGTC_1986 st071812 45 µM 1.66028129709252 0.047139846563862 no 210 0.0484289382192209 278 11838594
SGTC_3237 9133362 49.47 µM 1.65532827878006 0.0476461462083638 no 211 0.048928962833749 336 43845137
SGTC_1790 st045711 43.5 µM 1.65328599967045 0.0478561729110968 no 212 0.0491363354776667 334 585119
SGTC_2941 9056145 11.23 µM 1.65328380451715 0.0478563990574045 no 213 0.0491365587501998 267 2119517
SGTC_2291 7917025 104.35 µM 1.65094097376183 0.0480982473572045 no 214 0.0493753141010094 380 2964612
SGTC_2943 9068529 45.32 µM 1.64652599965622 0.0485566586608093 no 215 0.0498277558644072 387 3270634
SGTC_2979 9012552 45.46 µM 1.63112726438834 0.0501829218340906 no 216 0.0514317344158985 276 17100905
SGTC_2247 cerulenin 830 nM 1.6205345377398 0.0513266156946071 no 217 0.0525587507074323 369 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1325 1431-0015 227 µM 1.61951786896626 0.0514374669753606 no 218 0.0526679424824629 320 1103340
SGTC_3162 9099653 49.47 µM 1.61637534665048 0.0517813124221949 no 219 0.0530065926300012 288 25237511
SGTC_182 3448-4371 550.524 µM 1.61051864792015 0.052427008048129 no 220 0.0536423388883101 385 3491403
SGTC_1175 0741-0056 27.6 µM 1.61030567526281 0.0524506079891023 no 221 0.053665570445843 411 765927
SGTC_977 1348-1378 135 µM 1.60845276018198 0.0526562893804782 no 222 0.0538680272109974 350 X977
SGTC_1259 0671-0132 43 µM 1.60269563361333 0.0532994407200974 no 223 0.0545009340038333 386 X1259
SGTC_602 3130-1533 38.1 µM 1.60186120907028 0.0533931720300289 no 224 0.0545931520426112 409 720941
SGTC_1143 3454-2408 5.08 µM 1.59962846894556 0.0536446192781203 no 225 0.0548405144844996 280 X1143
SGTC_1015 4130-4525 82 µM 1.59819821324994 0.053806184413562 no 226 0.0549994356363152 369 1363237
SGTC_2395 5646831 180.19 µM 1.5946333309295 0.0542105594295105 no 227 0.0553971272840984 378 6808628
SGTC_208 k072-0098 12.366 µM 1.59133745701782 0.0545865559519668 no 228 0.0557668256941829 458 5948901
SGTC_2261 9010538 184.68 µM 1.58699875857221 0.0550846596376934 no 229 0.0562564628951377 308 6457250
SGTC_1886 st057356 49.9 µM 1.58463855365296 0.0553571268147551 no 230 0.0565242400539882 360 24207747
SGTC_768 0384-0033 77.3 µM 1.58310818759179 0.0555343635939996 no 231 0.0566984038875432 463 3965305 YMR134W ERG29
SGTC_2271 7849410 118.62 µM 1.58205611696832 0.0556564670046514 no 232 0.0568183801518111 348 972430
SGTC_1204 4049-0315 18.3 µM 1.57935258153075 0.0559712114923121 no 233 0.057127603683872 388 588402
SGTC_1206 3978-0017 132 µM 1.57772654242756 0.0561611894034714 no 234 0.0573142229246082 356 3873677
SGTC_1241 0364-0022 50.8 µM 1.57663708315243 0.0562887603385572 no 235 0.0574395274627353 405 4563895
SGTC_2516 gossypol 71.55 µM 1.57593148925662 0.0563715041238338 no 236 0.0575207965143976 396 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3069 9117009 49.47 µM 1.57243424325921 0.0567830362499089 no 237 0.0579249389792927 258 41904981
SGTC_3341 9147222 25.867 µM 1.56793292271618 0.057316199721041 no 238 0.0584483937080694 356 1939759
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.56614821377534 0.057528678792605 no 239 0.0586569615170465 341 364106
SGTC_3342 9147791 14.508 µM 1.56035732783969 0.0582223834045148 no 240 0.0593377314701429 370 1838168
SGTC_1885 st057546 99.9 µM 1.55654017521873 0.0586832316109552 no 241 0.0597898485240463 414 702008
SGTC_1304 1165-0502 251 µM 1.54741781872192 0.0597961797827543 no 242 0.0608812636185341 462 767425
SGTC_490 phenamil 164 µM 1.54727339749511 0.0598139315456495 no 243 0.0608986668597952 273 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1732 st034308 51.822 µM 1.54362856354477 0.0602633103139631 no 244 0.0613391706090402 400 830119
SGTC_695 3505-6186 243 µM 1.54328910549259 0.0603052969308328 no 245 0.0613803228863897 396 1819379
SGTC_3209 9113616 49.47 µM 1.54144611901136 0.0605336504940428 no 246 0.0616041234599559 429 16649353
SGTC_1914 st062367 72.6 µM 1.53850492202911 0.0608994774444686 no 247 0.0619626029950329 381 978205
SGTC_2625 euphol 100 µM 1.53612113365114 0.0611972400635697 no 248 0.0622543369790544 452 6708538 A triterpene alcohol.
SGTC_491 tetrandrine 80.3 µM 1.53393833293259 0.0614708937295357 no 249 0.0625224122115847 323 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1100 amiodarone 5.07 µM 1.5249111389602 0.0626127774480017 no 250 0.0636406315865278 435 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_743 1275-0778 158 µM 1.52425950259036 0.062695840996095 no 251 0.0637219496342768 429 2849257 YMR203W TOM40
SGTC_1739 st037196 92.5 µM 1.52138262761943 0.0630635807832535 no 252 0.0640819229220073 415 612214
SGTC_2105 5350118 200 µM 1.51963698588896 0.0632875370234148 no 253 0.0643011184422555 398 2133313
SGTC_2974 9094440 9.66 µM 1.51911201444284 0.063355008942653 no 254 0.0643671515282068 457 25236134
SGTC_1976 st070609 63.5 µM 1.51726559897625 0.0635927642631034 no 255 0.0645998199781661 416 682556
SGTC_408 cantharidin 100 µM 1.51687946634373 0.0636425726380469 no 256 0.0646485593840296 437 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3013 9080133 71.4286 µM 1.51396689706446 0.0640192519866275 no 257 0.0650171177546566 460 17050193
SGTC_38 0929-0051 58.268 µM 1.51163582826644 0.0643219735542387 no 258 0.0653132659325575 454 1379719
SGTC_2116 5511452 16.8835 µM 1.50888912148711 0.0646800977598827 no 259 0.065663560154751 432 870744
SGTC_1417 3966-0327 90.4 µM 1.50878201371306 0.0646940941125152 no 260 0.0656772493197512 452 651118
SGTC_3052 9092717 49.47 µM 1.50525895509862 0.0651557836172994 no 261 0.0661287566327361 425 25237534
SGTC_2809 7964133 12.99 µM 1.50386415316209 0.0653392744299962 no 262 0.0663081743202439 455 1253665
SGTC_2035 5154463 94.595 µM 1.50372891540891 0.0653570867000821 no 263 0.066325590398611 450 2769623
SGTC_1651 st011928 86.1 µM 1.50323746113286 0.0654218482434352 no 264 0.0663889102910699 402 720198
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.50219053734103 0.065559972895878 no 265 0.0665239539686235 411 688669
SGTC_1010 4112-3296 15.2 µM 1.50036731863653 0.0658010567774052 no 266 0.0667596401470495 449 704384
SGTC_1042 0350-0096 82 µM 1.50017810611655 0.0658261156201899 no 267 0.0667841364741143 400 3122515
SGTC_3308 9128332 17.569 µM 1.49890173808857 0.0659953479537685 no 268 0.0669495627128478 530 17332805 YDL196W YDL196W
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.49496814528697 0.0665190198124015 no 269 0.0674613779234306 526 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1676 st018489 23.4 µM 1.494633606996 0.0665637042685819 no 270 0.0675050451557425 453 3696235
SGTC_3043 9092303 49.47 µM 1.49432362338844 0.0666051296787259 no 271 0.0675455267627642 388 25236084
SGTC_2644 guaiazulene 100 µM 1.49430905240789 0.0666070773979176 no 272 0.0675474300884656 379 3515 A coloring agent.
SGTC_1280 0880-0253 10.1 µM 1.49194903004202 0.066923126414574 no 273 0.0678562539108721 453 6836607
SGTC_2734 clemastine 41.6 µM 1.49134635795083 0.0670040205934053 no 274 0.0679352918766862 246 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2967 9089538 49.85 µM 1.48969818688293 0.0672256340125388 no 275 0.0681518057859073 461 728216
SGTC_1942 st076330 65.2 µM 1.4888985613138 0.0673333557943385 no 276 0.0682570412395367 411 24208414
SGTC_3189 9110682 49.47 µM 1.48762138226104 0.0675056880219297 no 277 0.0684253856153516 423 17122418
SGTC_627 1391-0720 175 µM 1.48663011121019 0.0676396769093491 no 278 0.0685562652436053 417 997839
SGTC_1984 st072354 53.1 µM 1.4836432737379 0.0680446464785273 no 279 0.0689517913613578 402 5762938
SGTC_1702 st027038 51 µM 1.4824672590458 0.0682046087688431 no 280 0.0691080045543457 451 5521182
SGTC_2570 licareol 100 µM 1.48034999572105 0.0684933317750342 no 281 0.0693899336423907 430 443158
SGTC_796 1234-0020 70.7 µM 1.47551133977703 0.0691566993828177 no 282 0.0700375609293175 452 46495034
SGTC_946 3434-1334 87.4 µM 1.47432400814769 0.0693202335706087 no 283 0.0701971870289843 434 4047976
SGTC_1606 st000094 49.2 µM 1.47284423918075 0.0695244626752324 no 284 0.0703965202177581 446 1242210
SGTC_713 1488-1073 324 µM 1.4719074251173 0.0696539956153413 no 285 0.0705229391231304 393 3312542
SGTC_2153 5569715 200 µM 1.47084162622017 0.0698015890819536 no 286 0.0706669760869211 406 2054701
SGTC_214 4373-3496 70 µM 1.46964644217923 0.0699673861856294 no 287 0.0708287675494326 607 3779166
SGTC_2012 4023501 200 µM 1.45448816982989 0.0720965348504213 no 288 0.0729055054948615 423 3477460
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.45118471740425 0.0725670660605101 no 289 0.0733642156297025 506 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_34 0469-0683 81.75 µM 1.45055096218373 0.0726576040550461 no 290 0.0734524693219455 425 3690923
SGTC_128 0906-2981 13.371 µM 1.44958615389181 0.0727956022061161 no 291 0.0735869797218066 398 6740226
SGTC_3241 9133421 49.47 µM 1.4448227873627 0.0734798572728004 no 292 0.0742538343429105 352 17018221
SGTC_1301 naphtanilide LB 4.81 µM 1.44425574490689 0.0735616391473515 no 293 0.0743335247180242 481 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2885 9057732 51.95 µM 1.44372466884683 0.0736382968556996 no 294 0.0744082196967767 443 6471414
SGTC_2159 5658611 73.75 µM 1.44330454406406 0.0736989826541283 no 295 0.0744673501476083 418 793844
SGTC_105 0111-0055 734.78 µM 1.44317211456442 0.0737181196313653 no 296 0.0744859963678145 367 5179370
SGTC_149 3970-0822 46.1 µM 1.44121126497861 0.0740019206357491 no 297 0.0747625034198357 611 3114250 YBL034C STU1
SGTC_1833 st055984 71 µM 1.4361595865136 0.0747369138610902 no 298 0.075478467904688 429 676288
SGTC_25 0118-0223 35.662 µM 1.43078371043502 0.0755251803256941 no 299 0.0762461065316392 453 5333628
SGTC_1910 st062352 60.4 µM 1.4240002786582 0.0765288583960932 no 300 0.0772231957020393 467 2245730
SGTC_3355 9151058 44.0485 µM 1.42339836747073 0.076618405081937 no 301 0.077310352738325 450 17015728
SGTC_2231 micatex 6.853 µM 1.42083869055794 0.0770000999501851 no 302 0.0776818299475136 410 20737 An antifungal of unknown mechanism.
SGTC_883 0850-0245 24.6 µM 1.41748896681274 0.0775017863482278 no 303 0.0781700089328574 496 6823229 YPR165W RHO1
SGTC_1555 citronellol 128 µM 1.41609855395605 0.0777107552641119 no 304 0.0783733257157207 423 8842 A terpine precursor.
SGTC_3157 9099274 49.47 µM 1.41490070922326 0.077891125319174 no 305 0.0785488050158921 433 17217662
SGTC_2015 5119600 184 µM 1.41382987185073 0.0780526395530918 no 306 0.0787059302472884 473 2828786
SGTC_1074 carmofur 3.8 µM 1.41069993874878 0.0785261835743035 no 307 0.0791665545280443 521 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2704 st078022 71.1 µM 1.41046651634051 0.0785615863516689 no 308 0.0792009883291209 457 54697681
SGTC_3067 9117431 49.47 µM 1.40956866553715 0.078697874619383 no 309 0.0793335423951695 417 17150885
SGTC_431 k089-0097 107 µM 1.4030606384109 0.079691114599442 no 310 0.0802993787148496 552 5499420
SGTC_459 nigericin 15.3 µM 1.39992897139403 0.0801724288699565 no 311 0.080767294695709 512 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1983 st071813 46.9 µM 1.39923591490462 0.0802792429124995 no 312 0.0808711249596704 486 11838595
SGTC_549 1661-1316 519 µM 1.39844363072564 0.0804014816578604 no 313 0.0809899444289251 484 2857282
SGTC_2730 imipramine 71.33 µM 1.39664184587682 0.0806799962256732 no 314 0.0812606500004436 582 3696 A tricyclic antidepressant.
SGTC_2847 9005661 71.43 µM 1.39605068548989 0.080771534612082 no 315 0.0813496162782298 325 2991449
SGTC_700 3453-2283 142 µM 1.39556969595763 0.080846071406645 no 316 0.0814220566626037 543 565664
SGTC_1575 cyproterone acetate 48 µM 1.39529426561 0.080888776990837 no 317 0.0814635602986187 486 9880 An androgen receptor antagonist and liver toxin.
SGTC_550 4123-0385 25.7 µM 1.39457030909375 0.0810011079424661 no 318 0.0815727268569982 471 5731123
SGTC_266 formosanin C 406 nM 1.38887997069163 0.0818881386503437 no 319 0.0824346260314259 510 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_477 mead ethanolamide 10 µM 1.38876816701775 0.0819056400518847 no 320 0.0824516290304483 297 16061185
SGTC_232 clozapine 119 µM 1.38549394992533 0.0824194267485001 no 321 0.0829507405998051 482 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_885 0865-0106 16.8 µM 1.38228121361728 0.082925920965294 no 322 0.0834426859956638 491 2793380
SGTC_1501 4491-0275 38.4 µM 1.38182908289112 0.082997387806518 no 323 0.0835120934736248 465 5104718
SGTC_729 4092-0585 94.1 µM 1.37924285482242 0.0834070751457493 no 324 0.0839099445230922 461 2169061
SGTC_88 0180-0332 8.668 µM 1.37921663128114 0.0834112370171298 no 325 0.0839139858846489 486 3101745
SGTC_3055 9094636 49.47 µM 1.37686205464902 0.0837855624083578 no 326 0.0842774504009118 454 25236176
SGTC_891 0929-0073 133 µM 1.37536537601231 0.0840241561600987 no 327 0.0845090988139809 476 5603632
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.37393382304962 0.0842528448505392 no 328 0.084731114026394 479 6708760
SGTC_1933 st074711 15.9 µM 1.37216193824328 0.0845365476456901 no 329 0.085006515644753 544 17250958
SGTC_106 0092-0003 11.579 µM 1.36894723580388 0.0850530936958453 no 330 0.0855078844585714 405 1072148
SGTC_945 3381-0768 11.3 µM 1.3673453721038 0.0853113663658107 no 331 0.0857585381944609 521 1126236 YIL048W NEO1
SGTC_1794 st048918 76.9 µM 1.36649221887493 0.0854491620606828 no 332 0.085892260748733 404 672303
SGTC_2784 7567673 72.73 µM 1.36597186042071 0.0855332887372279 no 333 0.0859738978958475 538 3471247
SGTC_1405 3909-7894 12 µM 1.36129810470406 0.0862916799665869 no 334 0.0867097508554916 501 7104060
SGTC_1323 1348-1351 11.2 µM 1.36007830640478 0.0864904367148714 no 335 0.0869025725923419 465 6989654
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.35969354727734 0.0865532012059596 no 336 0.0869634604699282 484 756377
SGTC_328 k915-0120 63.5 µM 1.35957810507971 0.0865720395507821 no 337 0.0869817353351134 480 6624543
SGTC_647 0140-0236 81 µM 1.35412550962419 0.0874653120444675 no 338 0.0878481694754899 571 990837
SGTC_2959 9079155 11 µM 1.35279260876208 0.0876847174868917 no 339 0.0880609473462604 436 16189457
SGTC_1503 4585-0012 61.3 µM 1.35249549091746 0.0877336812235733 no 340 0.0881084301372486 468 2922052
SGTC_658 3253-0951 102 µM 1.34814114239524 0.0884536005954301 no 341 0.0888064954182278 626 1184878
SGTC_2136 5328288 199.296 µM 1.3407376373195 0.0896877367287974 no 342 0.0900028250405074 429 262395
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.33927946326977 0.089932310610259 no 343 0.0902398559046187 461 279621
SGTC_17 0960-0276 49.807 µM 1.33724287558126 0.0902747286345865 no 344 0.0905716853470475 563 6821114
SGTC_2650 prasterone 100 µM 1.33666874798723 0.0903714332918728 no 345 0.0906653937361877 427 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1991 st073000 8.92 µM 1.33318597241398 0.0909597128116457 no 346 0.0912353907756682 585 4301969 YIL048W NEO1
SGTC_548 1436-0017 110 µM 1.33253904973611 0.091069297389096 no 347 0.0913415592297656 619 9677137
SGTC_968 1309-0633 340 µM 1.32867287867354 0.0917262440469093 no 348 0.0919779582375915 531 3761976
SGTC_737 1950-0117 57.9 µM 1.32296729271147 0.0927021515367489 no 349 0.0929231274877459 513 5393513
SGTC_848 0368-0089 85.6 µM 1.32275687828415 0.0927382879654572 no 350 0.0929581208526379 541 762535
SGTC_3191 9110352 49.47 µM 1.32071625042123 0.0930892845451043 no 351 0.0932979967825728 485 17122424
SGTC_270 tamoxifen 5.46 µM 1.32065210382222 0.0931003339254167 no 352 0.0933086955569692 572 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_984 1492-0255 2.91 µM 1.31927217081249 0.0933382649194795 no 353 0.0935390690183047 488 1585198
SGTC_1162 k048-0130 20.1 µM 1.31765012057698 0.0936185162895199 no 354 0.0938103995785119 533 6797406
SGTC_2374 9071832 200 µM 1.31678773638991 0.0937677683439095 no 355 0.0939548923527203 496 17381698
SGTC_1974 st069448 26.9 µM 1.31550048972626 0.0939908776364854 no 356 0.0941708764327202 502 6323587 YNR016C ACC1
SGTC_1605 st000082 49.1 µM 1.31539995187661 0.0940083196244555 no 357 0.0941877608492123 513 1114022
SGTC_1324 1418-0026 34.4 µM 1.31511234803724 0.094058228277555 no 358 0.0942360736269318 553 1372513
SGTC_2991 9074669 71.4286 µM 1.31465824780751 0.094137069287104 no 359 0.0943123923078721 608 17333109
SGTC_2036 5160441 105 µM 1.3142187443348 0.0942134224219972 no 360 0.0943863011751717 617 134534 YIL048W NEO1
SGTC_867 0518-0118 155 µM 1.31264061329769 0.0944879611591927 no 361 0.0946520387655134 539 6848158
SGTC_2355 9061122 103.12 µM 1.31140453830438 0.0947034058804733 no 362 0.0948605631952533 522 5302957
SGTC_2945 9067681 61.76 µM 1.3090569448342 0.0951135818416631 no 363 0.0952575310712355 500 16456930
SGTC_402 epigallocatechin gallate 10 µM 1.30344741481074 0.0960989851616823 no 364 0.0962110289824668 579 65064 An antioxidant.
SGTC_1354 1498-1681 81 µM 1.30310633556907 0.0961591423370291 no 365 0.0962692304746939 587 5754243
SGTC_2568 diosmetin 100 µM 1.30221849622717 0.0963158630551877 no 366 0.0964208520241829 558 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1476 4112-3294 3.34 µM 1.30210537649784 0.0963358443377442 no 367 0.0964401827419009 520 704369
SGTC_1673 st016611 27.3 µM 1.30197698222953 0.0963585273807348 no 368 0.096462127133565 559 5226799
SGTC_3292 9120825 59.784 µM 1.29727181861796 0.0971924845428626 no 369 0.0972688386571461 543 24824900
SGTC_1962 st076595 64.5 µM 1.29380934240552 0.0978095585103133 no 370 0.0978656424404767 549 279619
SGTC_897 1000-0139 31.4 µM 1.28983618899003 0.098521176924824 no 371 0.0985537700139501 540 6151020
SGTC_2942 9052777 62.25 µM 1.28585212053734 0.0992385490563004 no 372 0.0992473381048147 614 6469503
SGTC_1688 st021091 57.6 µM 1.28249932919362 0.0998452068120122 no 373 0.0998337700579676 539 3656366
SGTC_1944 st076371 56.9 µM 1.27912852913134 0.100457849335229 no 374 0.100425899351234 541 24208455
SGTC_2135 5326629 150.42 µM 1.27702239165052 0.100842029268549 no 375 0.100797171041644 526 5020077
SGTC_2675 theaflavin digallate 100 µM 1.27552617282803 0.10111560423338 no 376 0.101061533186314 588 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_211 3455-0679 143.504 µM 1.27495962686753 0.101219334948016 no 377 0.101161766184351 582 748649
SGTC_3066 9117245 49.47 µM 1.26977422108608 0.102172352023661 no 378 0.102082532931571 579 17176980
SGTC_2435 5706476 10.6 µM 1.26920302094912 0.10227772974334 no 379 0.102184331948428 616 5725375
SGTC_159 3970-0959 50 µM 1.26903751429806 0.102308277963489 no 380 0.102213842259268 784 6615653
SGTC_3350 9150499 3.57 µM 1.26546137061361 0.102969962543526 no 381 0.102852993768979 628 4910996 YPR165W RHO1
SGTC_2849 9019321 12.99 µM 1.26240301985456 0.103538302898466 no 382 0.103401901568385 527 16489627
SGTC_235 0330-0087 5 mM 1.2609255107157 0.103813685953573 no 383 0.103667842998259 594 46494818 YHR062C RPP1
SGTC_59 0330-0160 1.33 µM 1.25867050761501 0.10423500451323 no 384 0.104074684104233 729 4293482
SGTC_1380 2291-0730 164 µM 1.25850712060215 0.10426557937571 no 385 0.104104206828015 526 2999191
SGTC_2026 5148700 152 µM 1.25062725508494 0.105747875978677 no 386 0.105535251009487 591 79838
SGTC_497 capsazepine 133 µM 1.24892892863394 0.106069337206694 no 387 0.105845534851968 558 2733484 A calcium channel blocker.
SGTC_2869 9037858 32.47 µM 1.24859539553727 0.106132551600481 no 388 0.105906548654005 529 27187042
SGTC_3210 9128157 49.47 µM 1.24548706933266 0.106722980475527 no 389 0.106476382850397 555 17590849
SGTC_2069 5228469 200 µM 1.24521202141979 0.10677533996284 no 390 0.106526912436822 552 2835210
SGTC_3291 9121177 71.43 µM 1.24312395255182 0.107173439739743 no 391 0.106911080264221 482 17015612
SGTC_2486 5283202 22.39 µM 1.23847023924101 0.108064539634156 no 392 0.10777087525539 561 1377751
SGTC_1410 3909-8106 77.9 µM 1.23271793748813 0.10917335479828 no 393 0.108840508574055 578 1039210
SGTC_1888 azatryptophan 97.5 µM 1.22728345265645 0.110228395721415 no 394 0.109858036386354 545 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1553 gossypol 38.6 µM 1.22608822347985 0.110461413083029 no 395 0.110082738514398 468 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2618 avocadyne 43.43 µM 1.22425763622573 0.11081898174068 no 396 0.110427526357718 579 3015189
SGTC_2473 5854593 8.94 µM 1.22331051263311 0.111004308610016 no 397 0.110606219018146 567 2872951
SGTC_2086 5274770 176.623 µM 1.21592550694043 0.112456974238171 no 398 0.112006650256316 586 689278
SGTC_1656 st012921 11 µM 1.21358296229722 0.11292058862564 no 399 0.112453508189904 560 6732821
SGTC_2741 miltefosine 3.04 µM 1.21198666824366 0.11323729272504 no 400 0.112758741983038 493 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_858 0438-0351 2.77 µM 1.20960841301934 0.113710312125209 no 401 0.113214594182604 662 2799119
SGTC_686 1319-0111 510 µM 1.20488847797995 0.114653243963774 no 402 0.11412317859948 664 4562600
SGTC_958 1222-0007 33 µM 1.20481030785732 0.11466890721339 no 403 0.114138269892377 671 7312461
SGTC_1448 4255-0083 152 µM 1.19971715516246 0.115692725482847 no 404 0.115124604066276 636 5399660
SGTC_1297 1068-0111 14.1 µM 1.19931041855836 0.115774766175031 no 405 0.115203632730026 591 767057
SGTC_560 2332-1943 155 µM 1.1991905514379 0.115798951819309 no 406 0.115226930191474 612 21177716
SGTC_3264 9137442 49.47 µM 1.19789982881445 0.116059608872805 no 407 0.115478008210711 588 17015726
SGTC_2276 7947513 42.08 µM 1.1974930117536 0.116141850452707 no 408 0.115557224877399 574 2105100
SGTC_2778 tioconazole 65.09 nM 1.19746174277291 0.116148173458343 no 409 0.115563315266712 639 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1180 1193-0155 285 µM 1.19553821708514 0.116537605926218 no 410 0.115938406959113 585 2921347
SGTC_2082 5219693 150 µM 1.19295275854811 0.117062509366824 no 411 0.116443937572837 639 2834649
SGTC_974 1326-0144 138 µM 1.19265017723389 0.117124049178506 no 412 0.116503202865232 647 5411856
SGTC_96 0929-0093 37.281 µM 1.19093382502136 0.117473559324685 no 413 0.116839782219058 583 6991579
SGTC_390 dec-rvkr-cmk 16.7 µM 1.18686242484006 0.118305592527164 no 414 0.117640945378337 654 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_515 4092-1064 102 µM 1.18666984131577 0.118345051922586 no 415 0.117678937715743 708 717353
SGTC_53 0973-0023 39.979 µM 1.18209275415521 0.119285613536812 no 416 0.118584449573763 612 674768
SGTC_1928 4'-methoxychalcone 40.3 µM 1.18192468735522 0.119320250301317 no 417 0.118617792667904 641 641818
SGTC_333 3486-0131 40.1 µM 1.18152452936246 0.119402747136525 no 418 0.118697207439838 650 6744690
SGTC_3133 9127736 49.47 µM 1.17587282342852 0.120572206530942 no 419 0.119822850109966 657 27243420
SGTC_2657 nystatin 74.44 µM 1.1739262669857 0.120976851968994 no 420 0.120212280144362 665 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_280 3448-3607 3.04 µM 1.17119693942301 0.121545825641329 no 421 0.120759812616793 652 626179
SGTC_2522 biochanin a 4.94 µM 1.16962717248382 0.121873920350307 no 422 0.12107551872874 610 5280373 A possible chelator.
SGTC_2896 9052656 71.43 µM 1.16508692194561 0.122826371789498 no 423 0.121991905041549 738 6469436
SGTC_3301 9125354 19.7965 µM 1.16236342354169 0.123400204327262 no 424 0.122543937004349 577 41905162
SGTC_1511 0906-3109 28.5 µM 1.15891022626935 0.124130478834457 no 425 0.12324639004017 751 2882180
SGTC_1818 st052136 56.3 µM 1.15855491938422 0.124205789546454 no 426 0.123318826717358 640 674169
SGTC_861 0443-0273 110 µM 1.15803184490057 0.124316718368531 no 427 0.123425520571925 668 6149169
SGTC_63 0099-0242 26.702 µM 1.15539655068797 0.124876641148507 no 428 0.123964036894479 719 3898502 YLR359W ADE13
SGTC_2337 9009472 200 µM 1.15447379235427 0.125073116117275 no 429 0.124152988556656 702 5742383
SGTC_1012 4112-3522 18 µM 1.15353282119361 0.125273691217411 no 430 0.124345877028268 656 3112398
SGTC_104 0074-0074 590.992 µM 1.15314644029693 0.125356116224103 no 431 0.124425141418685 516 3943124
SGTC_473 2-arachidonoylglycerol 10 µM 1.15018725728654 0.125988641586855 no 432 0.125033376722396 649 5282280 An endocannabinoid.
SGTC_846 0335-0850 148 µM 1.1488799018072 0.126268796404212 no 433 0.125302753058863 633 6819598
SGTC_426 0988-0037 14.6 µM 1.1483057156246 0.126391976580702 no 434 0.125421190210592 722 5383008
SGTC_139 0099-0334 718.624 µM 1.1463104260311 0.126820677008597 no 435 0.12583336524215 768 97690
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.14411212897292 0.12729416577543 no 436 0.126288569105352 719 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2820 7989630 71.43 µM 1.14201459465019 0.127747096509091 no 437 0.126723976616713 547 2984098
SGTC_1197 1601-0112 267 µM 1.13962325749403 0.12826483453438 no 438 0.127221645814893 695 7350313
SGTC_3278 9139605 49.47 µM 1.1300913016414 0.130343026961536 no 439 0.129218877295612 664 7958859
SGTC_2311 7694451 200 µM 1.12927924361113 0.130521145490902 no 440 0.129390027039789 675 2163142
SGTC_1122 capsaicin 818.572 nM 1.12230139682156 0.132058619054377 no 441 0.130867156237905 697 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2880 9042983 58.44 µM 1.11999153417629 0.132570306224194 no 442 0.131358684857116 677 6464714
SGTC_109 0132-0036 33.701 µM 1.11993002912023 0.132583949638416 no 443 0.131371790262561 558 67274 A color developer.
SGTC_3057 9095946 49.47 µM 1.1180071962024 0.133010971666478 no 444 0.1317819599653 692 24540043
SGTC_2462 5162487 171.77 µM 1.11728444333256 0.133171724906721 no 445 0.131936362450698 712 2259986
SGTC_2214 7179297 48.276 µM 1.11328325495621 0.134064079743252 no 446 0.132793397904536 697 769744
SGTC_928 2764-0428 58.7 µM 1.1126170548015 0.134213055359354 no 447 0.132936466271344 739 662578
SGTC_327 1273-0057 3.96 µM 1.11255311499028 0.134227359551927 no 448 0.132950203105816 658 3108138
SGTC_1146 3579-1023 7 µM 1.11168104029946 0.134422558881349 no 449 0.133137657268898 775 X1146
SGTC_500 h-89 112 µM 1.11022262678446 0.134749435684281 no 450 0.133451552411586 747 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_569 4130-2812 160 µM 1.10959354061973 0.134890602117853 no 451 0.133587107989815 566 743552
SGTC_685 1278-0033 54.9 µM 1.10622405968673 0.135648437646095 no 452 0.134314775775237 718 3590572
SGTC_1055 3448-0672 86 µM 1.10538901103706 0.135836699927844 no 453 0.13449553165904 693 748378
SGTC_1808 st050063 61.5 µM 1.10469019525884 0.135994385877598 no 454 0.134646926666716 698 4011993
SGTC_1281 0884-0031 11.8 µM 1.10241929258877 0.136507674184387 no 455 0.135139713976496 734 1548255
SGTC_334 1502-1024 68.5 µM 1.1014678160938 0.13672312820178 no 456 0.135346552138147 716 3296216
SGTC_1741 st038134 10.228 µM 1.10092449655881 0.136846262665047 no 457 0.135464759760656 741 1272587
SGTC_3022 9087993 49.47 µM 1.10072933751982 0.136890510758901 no 458 0.13550723691248 680 17173644
SGTC_2001 4023502 57.655 µM 1.0985060103067 0.137395292423741 no 459 0.135991797314825 708 108941 YCR052W RSC6
SGTC_1464 k208-0027 110 µM 1.09839546417422 0.13742042381668 no 460 0.13601592107799 725 X1464
SGTC_299 1273-0059 1.44 µM 1.09737571265162 0.1376524006269 no 461 0.136238592972823 673 2848077
SGTC_2911 7942208 15.64 µM 1.09662538625414 0.137823258201349 no 462 0.136402592685739 669 1243384
SGTC_648 0375-0473 33.3 µM 1.08886091317493 0.139599810055732 no 463 0.138107612538583 748 1713139
SGTC_2028 5153890 36.43 µM 1.08765833612471 0.13987635246734 no 464 0.138372983591825 705 2830968 YPR165W RHO1
SGTC_1506 4226-2149 212 µM 1.08526221469386 0.140428469559559 no 465 0.138902768019483 772 991114
SGTC_1237 0330-0133 46.1 µM 1.08190980741694 0.141203415472225 no 466 0.139646303275345 687 X1237 YHR072W ERG7
SGTC_196 k015-0023 18.111 µM 1.08173879976169 0.141243023349778 no 467 0.139684303720647 743 5211998
SGTC_1856 st057054 55.7 µM 1.07756801432534 0.142211370616239 no 468 0.140613291420279 762 1266018
SGTC_1813 st051246 8.6015 µM 1.07689232974548 0.142368668758076 no 469 0.140764185090401 692 5291959
SGTC_346 4513-0042 7.16 µM 1.07665111643659 0.142424851276553 no 470 0.140818079375073 747 2827372
SGTC_2226 7298446 200 µM 1.07322140988788 0.143225308572589 no 471 0.141585893393457 684 3283010
SGTC_1635 st007035 42.4 µM 1.07101485803148 0.143741897756411 no 472 0.14208137447902 875 3716403
SGTC_292 k038-0015 474 µM 1.07038841235834 0.143888787587907 no 473 0.142222256460499 701 46368540
SGTC_3306 9127676 59.7925 µM 1.06960780823281 0.14407196635695 no 474 0.142397939530348 693 41905287
SGTC_982 1491-0518 27.5 µM 1.06916519628237 0.144175900758734 no 475 0.14249761914111 669 3091256
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.06864141113587 0.144298961591346 no 476 0.142615640534337 739 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_486 niguldipine 82 µM 1.06836017884051 0.144365064987887 no 477 0.142679036200022 681 1236 A calcium channel blocker.
SGTC_130 0136-0219 337.655 µM 1.06738628106466 0.144594136471341 no 478 0.142898720430638 747 234244
SGTC_2480 5767542 37.17 µM 1.06710341611761 0.144660715286009 no 479 0.142962569706979 757 2867358
SGTC_3104 9120930 49.47 µM 1.06687387418022 0.144714758471086 no 480 0.143014396892532 671 17014836
SGTC_1835 st008666 49.2 µM 1.06660752308072 0.144777485020136 no 481 0.143074550954424 628 690455
SGTC_1220 1838-0075 193 µM 1.06189897023715 0.145889387490674 no 482 0.144140776315701 752 5529645
SGTC_600 1495-0418 41.6 µM 1.06148705828688 0.145986930797243 no 483 0.144234305643463 721 5377768
SGTC_2588 indole-3-carbinol 100 µM 1.05690727541664 0.147074403684868 no 484 0.145276953864409 790 3712 Induces cell cycle arrest.
SGTC_2951 9072950 58.06 µM 1.05650494633036 0.147170195898826 no 485 0.145368791110072 806 16488155
SGTC_1798 st045719 60.953 µM 1.05510487153684 0.147503871532616 no 486 0.145688682141629 708 3980186
SGTC_789 1309-1135 70.6 µM 1.05400529757944 0.147766284779295 no 487 0.14594024586522 741 3092424
SGTC_816 0325-0417 81.3 µM 1.05273085162097 0.148070822126823 no 488 0.146232182316124 730 68101
SGTC_884 0851-0618 334 µM 1.05001256742185 0.14872177673671 no 489 0.14685616736912 774 9642473
SGTC_362 0310-0100 9.03 µM 1.04397191015277 0.150175187782581 no 490 0.148249192958232 715 790235
SGTC_2142 5622915 118.518 µM 1.04194485524487 0.150665021365264 no 491 0.148718623159801 725 5322196
SGTC_788 1182-0090 188 µM 1.04132474994394 0.150815080802608 no 492 0.148862426869273 877 5715185
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.04084728866543 0.150930689553518 no 493 0.148973214428017 808 23847180
SGTC_1311 1190-0148 100 µM 1.03616189871117 0.152068302290433 no 494 0.150063309364234 887 1961333
SGTC_2995 9067767 71.4286 µM 1.03451464939562 0.152469603925268 no 495 0.150447815942858 684 11673567
SGTC_429 1112-0049 25.5 µM 1.03419064816738 0.152548619495315 no 496 0.15052352259811 724 2836170
SGTC_2148 5546263 113.568 µM 1.03414245126881 0.152560375800876 no 497 0.150534786531822 753 792097
SGTC_244 nsc-207895 1.295 µM 1.03193054945168 0.153100555163412 no 498 0.15105232675607 651 42640
SGTC_441 propafenone 146 µM 1.03177004343912 0.153139802395041 no 499 0.151089927933069 717 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_592 k241-0073 46.5 µM 1.03068216187885 0.153405988983015 no 500 0.151344946255173 818 4230158
SGTC_1519 esterone 74 µM 1.0303250775754 0.153493428365755 no 501 0.151428715380773 768 698 A steroid.
SGTC_3134 9127454 49.47 µM 1.02909409817799 0.153795111793964 no 502 0.151717729615641 796 24262820
SGTC_1792 st045773 43.6 µM 1.02713785427466 0.154275347035332 no 503 0.152177778053382 753 2919270
SGTC_1080 nisoldipine 24.4 µM 1.02702353403165 0.154303441968276 no 504 0.152204691276996 791 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_3108 9121785 49.47 µM 1.02571537878016 0.154625170360616 no 505 0.152512881610753 763 17140271
SGTC_2228 7354201 200 µM 1.02346435270139 0.155179825928181 no 506 0.153044173042874 791 753451
SGTC_2007 4011539 71.82 µM 1.02285040234233 0.155331331728836 no 507 0.153189291453531 767 45595301
SGTC_2484 5809818 12.04 µM 1.02228316916153 0.15547139576543 no 508 0.153323448422492 743 2870548
SGTC_95 0471-0001 561.058 µM 1.02224225134652 0.155481502616944 no 509 0.153333128950883 745 4015405
SGTC_3110 9122132 49.47 µM 1.0166632650552 0.156863591715604 no 510 0.154656823392107 811 918317
SGTC_2052 5265182 7.135 µM 1.01637477197303 0.156935279601852 no 511 0.154725477235532 796 1239884
SGTC_760 0568-0725 82.9 µM 1.01593930829888 0.15704352914788 no 512 0.154829144385226 842 3916171
SGTC_641 4092-0595 30 µM 1.01478424386219 0.157330898184902 no 513 0.155104343010617 801 786260
SGTC_1494 4358-1428 177 µM 1.01348734115599 0.157653966937984 no 514 0.155413719804889 830 1564571
SGTC_1795 st049545 62.3 µM 1.01305478546707 0.157761816846378 no 515 0.155516996672989 787 5291882
SGTC_2915 7971052 15.16 µM 1.01136529452769 0.158183524917171 no 516 0.155920812714079 623 5741558
SGTC_811 0416-0114 265 µM 1.01071898945061 0.15834504237803 no 517 0.156075472845448 771 6612453
SGTC_2649 anisomycin 9.56 µM 1.00989870772668 0.158550193926921 no 518 0.156271910937722 782 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2603 homopterocarpin 100 µM 1.00694861137589 0.159289449866699 no 519 0.156979734915939 785 101795 A weak amylase inhibitor.
SGTC_3262 9137218 49.47 µM 1.00509220224887 0.159755797205609 no 520 0.157426227264164 653 17650664
SGTC_1228 0124-0032 52.5 µM 1.00466478042773 0.159863295948936 no 521 0.157529146284926 837 X1228
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.00216647202425 0.160492579440743 no 522 0.158131598982676 1011 16725076
SGTC_3165 9101544 49.47 µM 1.00200959480317 0.160532148203841 no 523 0.158169479416524 804 5002184
SGTC_2642 cholecalciferol 100 µM 1.00182462190282 0.160578811658789 no 524 0.158214151637358 804 9821465 A vitamin D precursor, similar to steriods.
SGTC_108 0509-0257 621.132 µM 1.00175871612139 0.160595439972509 no 525 0.158230070334841 820 536624
SGTC_1333 1482-0047 286 µM 0.996588821106428 0.161903331132159 no 526 0.159482067159855 846 3811116
SGTC_2259 7964009 200 µM 0.995973152860126 0.162059545322921 no 527 0.159631594884 758 313134
SGTC_2877 9040724 71.43 µM 0.995549279311984 0.162167152269854 no 528 0.159734594621763 824 6463895
SGTC_341 1486-1430 230 µM 0.995089692065122 0.162283878257521 no 529 0.159846321781411 775 2054753 YPL210C SRP72
SGTC_2816 7982706 58.44 µM 0.994987432775536 0.162309857513128 no 530 0.159871188299385 761 2981853
SGTC_1312 1218-2183 165 µM 0.992949836677906 0.162828078823129 no 531 0.160367200562176 841 6744073
SGTC_2155 5570423 76 µM 0.992598529907035 0.162917535215187 no 532 0.160452820742778 750 797402
SGTC_2075 5212009 200 µM 0.989296215838491 0.16375999464457 no 533 0.161259117488244 721 780898
SGTC_1552 6-methylflavone 10.6 µM 0.985789050899574 0.164657804636628 no 534 0.162118319880576 785 689013
SGTC_1133 3473-0247 50 µM 0.980868980034077 0.165922673641746 no 535 0.163328678131671 781 711311
SGTC_2895 9054447 58.44 µM 0.979626069067427 0.166243196492153 no 536 0.16363536594047 793 2697450
SGTC_391 gliotoxin 8.33 µM 0.978714028139072 0.166478648540777 no 537 0.163860649379847 867 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2674 ligustilide 100 µM 0.978148157545298 0.166624841590398 no 538 0.164000526340493 783 5319022 A signalling regulator.
SGTC_1277 0873-0036 22 µM 0.97660028845844 0.167025157760251 no 539 0.164383538125053 845 5965735
SGTC_607 4491-0986 66.8 µM 0.975208452457528 0.167385649150981 no 540 0.164728435121466 863 698981 YDR232W HEM1
SGTC_782 0083-0095 30.5 µM 0.974836463928228 0.167482080591779 no 541 0.16482069322185 868 3591729 An indicator and reagent.
SGTC_725 1497-0963 19 µM 0.969783260517256 0.168795578503265 no 542 0.166077269214233 870 3549977
SGTC_923 1900-2434 73.3 µM 0.969196657738862 0.16894848399796 no 543 0.166223539176141 809 5910570
SGTC_2447 5741742 33.78 µM 0.96912668345582 0.168966729625197 no 544 0.166240992883538 845 1776504
SGTC_3196 9111891 49.47 µM 0.966996212253806 0.16952285075958 no 545 0.166772963591358 828 18891510
SGTC_1185 1319-0113 81.3 µM 0.964193370561341 0.170256268805429 no 546 0.167474493732792 801 4672763
SGTC_265 mycophenolic acid 32.932 µM 0.962571525003664 0.170681583320602 no 547 0.167881296554904 886 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1907 st060210 83.7 µM 0.961988359022191 0.170834679486381 no 548 0.168027725745435 910 688793
SGTC_296 1222-0039 74.9 µM 0.959764484930357 0.171419310205057 no 549 0.168586880201175 790 5984176
SGTC_3174 9107204 49.47 µM 0.958455246196758 0.171764091198615 no 550 0.168916624242731 824 3938802
SGTC_1053 3366-3204 134 µM 0.956720569054168 0.172221590806757 no 551 0.16935415663655 829 3632071 YPR165W RHO1
SGTC_2328 6201408 200 µM 0.954829789338775 0.172721145363818 no 552 0.169831890080417 806 2890418
SGTC_1217 1183-1422 255 µM 0.95475676607927 0.172740457024349 no 553 0.169850357801078 899 2849664
SGTC_2013 4024628 200 µM 0.951261501936515 0.173666420495361 no 554 0.170735822370491 780 5230760
SGTC_204 PMA1.184 62.41 µM 0.950965835741179 0.173744892824714 no 555 0.170810859568229 897 2252213 YGL008C PMA1
SGTC_3153 9100258 49.47 µM 0.949485157290015 0.174138216759426 no 556 0.171186958748334 781 25236848
SGTC_1308 1187-1617 41.4 µM 0.948971119739745 0.174274896722757 no 557 0.171317650401235 875 2882570
SGTC_814 3342-0569 96 µM 0.948874384258028 0.174300625813292 no 558 0.171342252076307 866 4346283
SGTC_1462 k081-0014 26.5 µM 0.948548443900999 0.174387335129713 no 559 0.171425161539164 689 3270634
SGTC_403 arphamenine a 50 µM 0.946971302435519 0.174807286191412 no 560 0.171826701218419 852 5487158 An arginine aminopeptidase inhibitor.
SGTC_1484 3473-2379 286 µM 0.94627337429499 0.174993330708832 no 561 0.172004585046478 1014 671917
SGTC_2756 carbadox 75.1 µM 0.945736330082559 0.175136574398118 no 562 0.172141543729799 834 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2320 7373003 200 µM 0.94444768726377 0.17548059226697 no 563 0.172470461201055 840 5415828
SGTC_921 1561-0023 372 µM 0.944179777069558 0.175552167688025 no 564 0.172538893784833 867 24050882
SGTC_2115 tiliquinol 12.7705 µM 0.944013912495447 0.175596489669867 no 565 0.172581269425191 847 71208 A bioactive hydroxyquinoline.
SGTC_1603 st002045 67.8 µM 0.94275053201808 0.175934320215709 no 566 0.172904259881816 887 5887985
SGTC_1705 st027868 56.3335 µM 0.941685355570566 0.176219470167796 no 567 0.173176877426442 880 292948
SGTC_1046 2001-0062 216 µM 0.941143141650132 0.176364734240026 no 568 0.173315754847668 836 739778
SGTC_1852 st056254 31.4 µM 0.939699999516194 0.176751734272529 no 569 0.173685732699671 844 442583
SGTC_1780 st038448 24.544 µM 0.937170236463027 0.177431422123781 no 570 0.174335498585326 867 728868 YDL195W SEC31
SGTC_2606 farnesol 9.78 µM 0.935323373590768 0.177928671325089 no 571 0.174810836591651 863 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2938 9059746 27.26 µM 0.934843459817758 0.178058026983157 no 572 0.174934489364128 824 6471769
SGTC_1065 prochlorperazine maleate 2.48 µM 0.934127247360416 0.178251184678466 no 573 0.175119129159881 894 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2703 st077852 53.4 µM 0.932033397049543 0.178816639056365 no 574 0.175659633087351 836 6281836
SGTC_1820 st053765 18.6 µM 0.931188613406861 0.179045096278914 no 575 0.175878003438697 842 3690829
SGTC_3172 9105863 49.47 µM 0.930374732590513 0.179265369969611 no 576 0.176088548171881 834 2348785
SGTC_2132 5317594 122.667 µM 0.930146729347818 0.179327108710519 no 577 0.176147559463201 820 794577
SGTC_599 1935-0052 86.5 µM 0.925455667549921 0.180600321117407 no 578 0.177364466909272 909 9557311
SGTC_3247 9135149 49.47 µM 0.924795711540711 0.180779895159601 no 579 0.177536090881147 840 8934436 YOR116C RPO31
SGTC_416 estradiol valerate 100 µM 0.924233078036713 0.18093307610489 no 580 0.177682488520704 872 13791 A steroid.
SGTC_2274 7947094 46.08 µM 0.919137485832398 0.182324089107134 no 581 0.179011832160989 961 2971028
SGTC_1880 MG-132 525 µM 0.918650871296602 0.182457275528337 no 582 0.179139107213406 848 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2056 5235370 200 µM 0.917909873064745 0.182660203482683 no 583 0.179333026162071 833 5511916
SGTC_1316 1272-0050 65.9 µM 0.913911470024415 0.183757626605627 no 584 0.180381683082337 882 7340392
SGTC_1262 0737-0114 49.6 µM 0.91309005852813 0.183983583146032 no 585 0.180597589235325 957 765919
SGTC_360 0957-0399 1.01 µM 0.911002072163159 0.184558731596626 no 586 0.181147140928419 914 6752301 YPR165W RHO1
SGTC_1945 st075991 56.6 µM 0.910093470408986 0.184809360208079 no 587 0.181386608910877 803 1084980
SGTC_894 0960-0238 55.9 µM 0.909804414857738 0.184889137595954 no 588 0.181462832944557 929 6741907 YDL195W SEC31
SGTC_3244 9134489 49.47 µM 0.909548167352983 0.184959878076787 no 589 0.181530422251004 887 16584271
SGTC_1959 st077091 55.8 µM 0.909496926558635 0.18497402578688 no 590 0.181543939706021 929 821356 YKL052C ASK1
SGTC_628 1636-0253 16 µM 0.906365635700981 0.185839858648451 no 591 0.182371177674338 903 4456143
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.905311960170273 0.186131774647297 no 592 0.182650070990863 906 641818 YHR062C RPP1
SGTC_2421 5690543 90.72 µM 0.905169354808771 0.186171304636245 no 593 0.182687837104961 894 3397993
SGTC_3272 9137413 49.47 µM 0.905163693627361 0.186172874014475 no 594 0.182689336453713 898 17614870
SGTC_3256 9138902 49.47 µM 0.900702302008141 0.187412197933747 no 595 0.183873312202659 956 17228773
SGTC_99 0109-0120 622.8 µM 0.899924167434745 0.187628875990187 no 596 0.184080303962397 880 759414
SGTC_1597 7-benzyloxygramine 47.5 µM 0.899040887784248 0.18787502004331 no 597 0.184315441099786 998 260807
SGTC_2940 9060638 45.86 µM 0.896445401052476 0.188599458901819 no 598 0.185007464229078 877 4027022
SGTC_1345 1488-0192 31.4 µM 0.895073896374941 0.188982960733936 no 599 0.185373793471347 947 658348
SGTC_1257 0669-0121 16 µM 0.892769687823991 0.189628346958012 no 600 0.185990261136262 1006 4307855
SGTC_2302 7771753 200 µM 0.892309222372562 0.189757481175966 no 601 0.186113606216102 926 2203047
SGTC_445 e6 berbamine 66 µM 0.892109953833893 0.189813381363967 no 602 0.186167000080877 992 6610268 A calcium/calmodulin antagonist.
SGTC_650 1328-0195 38 µM 0.890196463456363 0.190350682258064 no 603 0.186680201650315 936 2780821
SGTC_1871 st057448 67.3 µM 0.887640903640008 0.191069729089713 no 604 0.187366971879923 955 691747
SGTC_2119 5528445 120.635 µM 0.887607693144675 0.191079084333737 no 605 0.18737590699448 930 791935
SGTC_3064 1327-0027 10 µM 0.885873401126441 0.191568016702093 no 606 0.187842875395446 798 16000455 YPR107C YTH1
SGTC_932 2857-0803 154 µM 0.884881241305727 0.191848071145924 no 607 0.188110343189056 981 674898
SGTC_1874 staurosporine 7.6 µM 0.884363586667718 0.191994287660894 no 608 0.188249986494706 958 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.883897148485808 0.192126095993229 no 609 0.188375868337103 890 688803
SGTC_2596 sinensetin 100 µM 0.88382533496069 0.192146394319664 no 610 0.188395253906618 859 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1229 0139-0193 12.2 µM 0.881824524266681 0.192712457359386 no 611 0.188935853686267 987 3090752
SGTC_1902 st060212 70.5 µM 0.881611065776358 0.192772908457977 no 612 0.188993584480136 986 688944
SGTC_2084 5306078 60.6385 µM 0.880968977914926 0.192954816527264 no 613 0.189167305479746 898 679340
SGTC_3169 9102970 49.47 µM 0.880474807219783 0.193094889973425 no 614 0.189301073476611 964 17027839
SGTC_427 1354-0053 47.3 µM 0.880445028483058 0.193103332785088 no 615 0.189309136198795 908 6813657
SGTC_385 1494-0393 12.4 µM 0.877732186251258 0.193873417947152 no 616 0.190044536637646 941 3090647
SGTC_230 MPP+ 141.667 µM 0.874745361211436 0.194723439126372 no 617 0.190856236325174 884 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2399 5884133 200 µM 0.874557375520644 0.194777013744821 no 618 0.190907394372371 915 722445
SGTC_2296 7971656 126.45 µM 0.874546790118429 0.194780030777686 no 619 0.190910275312563 915 666570
SGTC_3097 9117246 49.47 µM 0.874489001432585 0.194796502109264 no 620 0.190926003645028 955 16423892
SGTC_2174 5790901 200 µM 0.874138343245839 0.194896467301472 no 621 0.191021459242252 893 786020
SGTC_2563 tomatine 8.54 µM 0.871973851484471 0.195514208204006 no 622 0.191611321357389 957 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2970 9090938 41.86 µM 0.871315851026234 0.195702235424655 no 623 0.191790858968177 994 17217104
SGTC_1282 0886-0010 32.4 µM 0.871315255224745 0.195702405727907 no 624 0.191791021581253 1034 2836211 YNL267W PIK1
SGTC_2149 5554786 194.827 µM 0.869481784881058 0.196226908927874 no 625 0.192291833417241 967 745063 YPR165W RHO1
SGTC_2765 myclobutanil 7.74 µM 0.868815324542412 0.196417775110674 no 626 0.192474074873058 933 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2180 6301957 200 µM 0.866871620994347 0.196975070574364 no 627 0.193006177170279 977 845462
SGTC_3015 9080845 49.47 µM 0.864403009875058 0.197684244814493 no 628 0.193683270007483 1025 5296973
SGTC_2185 6113692 200 µM 0.863526521872583 0.197936410063903 no 629 0.193924021901215 879 874150
SGTC_1821 st053465 65.6 µM 0.863236686378014 0.198019838348395 no 630 0.194003673417312 913 675086
SGTC_206 4546-0025 72.014 µM 0.862920070271754 0.198110999618293 no 631 0.194090707460306 991 6620745 YIL048W NEO1
SGTC_2434 5670830 169.91 µM 0.862159660417735 0.198330043095489 no 632 0.194299832326715 921 1549830
SGTC_2727 riluzole 51.77 µM 0.861050361371738 0.198649849517248 no 633 0.194605153259162 926 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1230 0170-0365 3.77 µM 0.860627785861301 0.198771758078818 no 634 0.194721538724968 1077 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2492 derrusnin 100 µM 0.858255183412845 0.199457065946185 no 635 0.195375785285273 892 1715307 Part of coumarin class of compounds.
SGTC_41 0478-0632 82.643 µM 0.855825452815728 0.200160346901502 no 636 0.196047167109588 1023 3750424
SGTC_1905 st060207 84.5 µM 0.855164193755012 0.200352004787871 no 637 0.19623012782338 951 1948547
SGTC_751 0833-0568 350 µM 0.854972707879254 0.200407525215972 no 638 0.196283128489865 953 6954252
SGTC_352 k048-0007 5.11 µM 0.854187270039453 0.200635355902689 no 639 0.196500617713131 1003 6811911
SGTC_42 0133-0086 60.653 µM 0.85389144018559 0.200721207089307 no 640 0.196582571402735 931 162923 Model of phenazepam hydroxylation.
SGTC_3033 9090887 49.47 µM 0.852943733466188 0.200996384380978 no 641 0.196845253817622 995 19325384
SGTC_2903 5923464 63.88 µM 0.852649573266973 0.201081843101689 no 642 0.196926831433902 978 2876576
SGTC_433 pimozide 108 µM 0.851703682225125 0.201356788783324 no 643 0.19718928819237 881 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1432 4049-0298 68.4 µM 0.851493132378419 0.201418020741933 no 644 0.19724773832571 973 741646
SGTC_3186 9110464 49.47 µM 0.846177662484202 0.202967556269954 no 645 0.198726820567849 957 17018021
SGTC_601 0986-0029 62.9 µM 0.846030098643928 0.203010674557659 no 646 0.198767976845704 983 24747981
SGTC_2889 9059656 51.95 µM 0.845883368441224 0.203053554678955 no 647 0.198808905712909 1010 3949838
SGTC_1763 st044482 94.5 µM 0.8446959386873 0.20340076554183 no 648 0.199140313807581 988 88505
SGTC_674 0498-0004 451 µM 0.844648300062543 0.203414702719241 no 649 0.199153616545184 925 4231473
SGTC_1361 1608-0041 5.61 µM 0.840342270805362 0.204676828454879 no 650 0.200358253552761 981 X1361
SGTC_632 0781-2353 4.65 µM 0.838953485402275 0.205084882115792 no 651 0.200747706087903 1003 6811515 YHR007C ERG11
SGTC_3107 9121808 49.47 µM 0.83613626407966 0.205914123292306 no 652 0.201539124656019 972 662681
SGTC_479 n-linoleoylglycine 10 µM 0.835665209625075 0.206052970678288 no 653 0.201671636250251 949 6433346 An anti-infammatory.
SGTC_1036 k216-0215 33.5 µM 0.835457394734289 0.206114243565493 no 654 0.2017301129194 971 622330
SGTC_2805 7950783 58.44 µM 0.834562852294956 0.206378116976656 no 655 0.201981942565177 1006 1178958 YDL195W SEC31
SGTC_2602 kawain 100 µM 0.834485159907809 0.206401044232526 no 656 0.202003823234843 1037 5369129
SGTC_2495 cafestol 54.53 µM 0.832266350446947 0.207056458347445 no 657 0.202629309819071 932 16667697 An anti-infammatory.
SGTC_1375 2910-0797 186 µM 0.826309766951803 0.208822052353636 no 658 0.204314197225767 987 742508
SGTC_2572 astragaloside iv 100 µM 0.826209632516125 0.208851808871195 no 659 0.204342592495167 977 45006101 An anti-inflammatory agent.
SGTC_1458 k015-0034 6.33 µM 0.825438918066593 0.209080922354209 no 660 0.20456122374792 960 3598957
SGTC_3102 9121669 49.47 µM 0.823446173938382 0.209673999307855 no 661 0.205127157250502 1008 41905072
SGTC_1565 sinapyl alcohol 95.1 µM 0.823181069674101 0.209752973657731 no 662 0.205202516148324 1006 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1827 berberine 7.24 µM 0.822426634432855 0.209977814998528 no 663 0.205417062930681 929 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3061 glucosamine 200 µM 0.821391832027286 0.210286443299344 no 664 0.20571155728528 995 91431 and experimental redox chemotherapeutic
SGTC_850 0388-0143 75.9 µM 0.819766141750001 0.210771840624549 no 665 0.206174718080901 974 67273
SGTC_830 4076-0286 57.8 µM 0.819267679925983 0.210920802503534 no 666 0.206316854100636 1098 6866659
SGTC_1948 st076329 66.6 µM 0.818057522588066 0.21128270642628 no 667 0.206662171116197 960 24208413
SGTC_2206 7254556 146.969 µM 0.81798942671619 0.21130308166058 no 668 0.206681612361522 1026 4398905
SGTC_1350 1495-0454 146 µM 0.816993048497857 0.211601343531406 no 669 0.206966200331285 1054 1069057
SGTC_588 3970-1144 52.9 µM 0.816768795585952 0.211668506713184 no 670 0.20703028394735 998 1888707
SGTC_1407 3909-7909 12.3 µM 0.815656834571414 0.212001720510958 no 671 0.207348216793603 1039 4411780
SGTC_1681 tripelennamine 100 µM 0.81200527090777 0.213098115406393 no 672 0.208394303509759 978 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_476 mead acid 10 µM 0.811525475715105 0.213242421056553 no 673 0.208531984491678 1016 5312531 An omega 9 fatty acid.
SGTC_2327 6189656 200 µM 0.810305455451263 0.213609617148665 no 674 0.208882320334978 1024 5349088
SGTC_1310 1188-0297 994 nM 0.810155362942182 0.213654816737078 no 675 0.20892544420358 1004 1588352
SGTC_3317 9138495 8.753 µM 0.806192727320703 0.214850158081896 no 676 0.210065865738012 1067 17020139
SGTC_1009 4106-0057 9.87 µM 0.801500738220399 0.216270522116449 no 677 0.211420908435763 1080 2928005
SGTC_2342 7990637 118.86 µM 0.800955652780247 0.216435882699669 no 678 0.211578659887638 1043 2033102 YER133W GLC7
SGTC_3204 9114183 49.47 µM 0.800705416872536 0.21651182035369 no 679 0.211651102942052 988 17027248
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.798762084611035 0.21710207673978 no 680 0.21221418975492 1106 368090
SGTC_2626 ethyl orsellinate 100 µM 0.797923272327141 0.217357139673924 no 681 0.212457508643948 1032 75653 A natural product.
SGTC_336 4111-0029 111 µM 0.797392007503001 0.217518774176297 no 682 0.212611699819372 977 3131175
SGTC_2072 5231554 129 µM 0.79720504215207 0.217575673891894 no 683 0.212665979085132 1134 789545
SGTC_1174 0739-0097 51.1 µM 0.79710313509287 0.217606691183885 no 684 0.21269556786881 1029 728447
SGTC_510 ag-490 170 µM 0.796906348493345 0.21766659403377 no 685 0.212752711793356 1145 5328779
SGTC_339 3091-4833 71.4 µM 0.796640123277445 0.217747649495831 no 686 0.212830033930784 1040 3240077
SGTC_940 3232-1287 54.8 µM 0.794824848791109 0.218300795547091 no 687 0.213357697177105 1050 1585493 YIL048W NEO1
SGTC_2193 5925765 200 µM 0.794399363376926 0.218430565448336 no 688 0.213481487344356 1045 877370
SGTC_2597 laccaic acid a 100 µM 0.794286110601702 0.218465114191607 no 689 0.213514444010259 1017 5491415 A textile dye.
SGTC_3090 9117696 49.47 µM 0.79357421078615 0.218682357467917 no 690 0.213721675422417 1034 7923821
SGTC_169 k015-0017 16.025 µM 0.791278790053887 0.219383674061465 no 691 0.214390661291278 1026 1840002
SGTC_657 3534-0529 86.7 µM 0.790734593254331 0.219550131043985 no 692 0.214549442405614 1069 1049549
SGTC_31 0508-1974 57.237 µM 0.790214970704599 0.21970913902391 no 693 0.214701117235795 1028 6810525
SGTC_492 tmb-8 126 µM 0.790210307260434 0.219710566368354 no 694 0.214702478750354 937 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1399 3562-5772 25 µM 0.788876595527558 0.220118995124761 no 695 0.215092068054859 976 23847490
SGTC_1787 fluconazole 80 µM 0.787655209835359 0.220493407475944 no 696 0.21544920566963 1015 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.786442708294803 0.220865457137299 no 697 0.215804085527931 1089 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2594 a-mangostin 100 µM 0.78637989778768 0.220884739994797 no 698 0.215822478386505 1062 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_3082 9117008 49.47 µM 0.78604985226212 0.220986079975271 no 699 0.215919140849914 1037 41448529
SGTC_1724 st037281 8.293 µM 0.785792993418399 0.221064966506447 no 700 0.215994386034704 1061 574124 YDL195W SEC31
SGTC_954 1189-0853 2.85 µM 0.785438478230208 0.221173871736009 no 701 0.216098263980482 1098 2828194
SGTC_1119 parthenolide 318.541 nM 0.785397894923086 0.221186340675418 no 702 0.216110157306813 1106 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_3109 9122853 49.47 µM 0.785143763078503 0.22126443006379 no 703 0.216184641693878 1105 1234709
SGTC_2336 9001819 198.65 µM 0.783108021088867 0.22189053973005 no 704 0.216781840662395 1080 2989602
SGTC_1070 indatraline 8.81 µM 0.782967090017756 0.221933921688424 no 705 0.216823219040369 1046 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1648 st011736 69.8 µM 0.781715880832708 0.222319286155071 no 706 0.217190783260608 1060 2855514
SGTC_1654 st012436 41.8 µM 0.780752331068902 0.222616313356964 no 707 0.217474087741387 1034 4323132
SGTC_3315 9136395 68.55 µM 0.779962391337082 0.222859991595534 no 708 0.217706506166737 1116 16876844
SGTC_372 0155-0182 15.9 µM 0.779146981349048 0.223111686143417 no 709 0.217946568771135 1093 771486
SGTC_2062 5245942 200 µM 0.779086140847435 0.223130472412829 no 710 0.217964486772511 1164 1376160
SGTC_3009 9080819 71.4286 µM 0.778971554663456 0.223165856665768 no 711 0.217998235601906 1084 17027216
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.778598973767204 0.22328093185252 no 712 0.218107991896696 1071 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_325 2810-4341 181 µM 0.777509315348412 0.223617677066417 no 713 0.218429170341084 1091 774970
SGTC_1521 st012942 49.4 µM 0.777339325103988 0.223670236440833 no 714 0.218479299769499 1095 24207259
SGTC_1799 st045822 46.1415 µM 0.776536455798359 0.223918570941972 no 715 0.218716152168102 1070 3674992
SGTC_3220 9131269 49.47 µM 0.776131315927639 0.224043943703542 no 716 0.21883572751375 1092 17722206
SGTC_1424 4048-1941 275 µM 0.776038983371098 0.224072522099672 no 717 0.218862984345373 1140 X1424
SGTC_2676 harmalol 100 µM 0.774994855842606 0.224395840263944 no 718 0.219171349644743 1084 5459187 A monoamine oxidase inhibitor
SGTC_396 dithiazanine 1.25 µM 0.77459161545923 0.224520776063697 no 719 0.219290506656982 1036 10578 An antihelmenthic.
SGTC_1214 0358-0031 63.7 µM 0.77425786927269 0.22462421035026 no 720 0.219389156378318 1046 4301366
SGTC_1493 4348-0038 111 µM 0.773914820379621 0.224730555887733 no 721 0.21949058239293 1135 800424
SGTC_489 paxilline 115 µM 0.773121066029858 0.224976730049945 no 722 0.21972536745878 1066 105008 A toxic potassium channel blocker.
SGTC_1758 st042942 75.2445 µM 0.772630929783725 0.225128816696891 no 723 0.219870417125733 1080 669317
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.770730522549733 0.22571905330441 no 724 0.220433338132289 1122 551469
SGTC_2436 5633522 8.09 µM 0.770363505148254 0.225833143913349 no 725 0.220542147711705 1095 5724242
SGTC_2718 lomofungin 53.02 µM 0.769659869582053 0.22605196643352 no 726 0.220750840450209 1078 5351222 A RNA synthesis inhibitor.
SGTC_728 3030-5151 22.5 µM 0.768999844657588 0.2262573354398 no 727 0.220946701375692 1056 3125388
SGTC_2838 9002687 71.43 µM 0.768946384286241 0.226273974430062 no 728 0.220962569975445 1022 6457060
SGTC_51 1013-0126 23.419 µM 0.768469141289035 0.226422542026273 no 729 0.221104258539754 1055 1627850
SGTC_1691 st019933 84.6 µM 0.768440240900412 0.226431540597948 no 730 0.221112840438627 1082 6176082
SGTC_1068 loratadine 26.9 µM 0.767966249848589 0.226579153671839 no 731 0.221253618102428 1050 3957 A H1 histamine antagonist.
SGTC_2233 sulbentine 40.3845 µM 0.766971434803035 0.226889141389224 no 732 0.221549249699269 1106 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_3031 9088762 49.47 µM 0.765540119360377 0.22733556350179 no 733 0.221974993033966 1094 205253
SGTC_2319 6033012 152.6 µM 0.765446362621086 0.227364823150311 no 734 0.222002897173932 1027 847246
SGTC_799 1310-0557 151 µM 0.764793588899109 0.227568599889011 no 735 0.222197232998948 1074 5354492
SGTC_2256 7954252 200 µM 0.764384865261602 0.227696243713594 no 736 0.222318962617707 993 2972920
SGTC_2242 6630449 61.2675 µM 0.76404970583307 0.227800943605314 no 737 0.222418811090004 1003 691249 YDR170C SEC7
SGTC_2210 7115885 190.385 µM 0.7606207489042 0.228873664935289 no 738 0.223441811486669 1108 2927039
SGTC_722 3534-0461 190 µM 0.75936458799199 0.229267353083771 no 739 0.22381724540201 1114 658262
SGTC_937 3122-0005 46.7 µM 0.758251537146634 0.229616506741808 no 740 0.224150206826327 1107 759535
SGTC_1496 4469-0713 57.4 µM 0.757511512832465 0.22984881021849 no 741 0.224371735558353 1082 746691
SGTC_2857 9024691 58.44 µM 0.75698982518501 0.230012653953809 no 742 0.224527979139383 1103 16478292
SGTC_2773 thioridazine 9.09 µM 0.756598814466002 0.230135499504181 no 743 0.224645125912157 1148 5452 An antipsychotic.
SGTC_2154 5570129 200 µM 0.756340161234459 0.230216781889811 no 744 0.224722637443192 1136 673366
SGTC_2485 5633444 17.78 µM 0.749789127699283 0.232280805206988 no 745 0.226690858941331 1090 5724239
SGTC_1273 0849-0096 14.1 µM 0.748800334343942 0.23259323455838 no 746 0.22698877909763 1099 5286025
SGTC_617 3770-0098 35 µM 0.748242480444853 0.232769602865115 no 747 0.227156955999199 1075 5962639
SGTC_65 0798-0905 34.986 µM 0.747863291819232 0.232889527662407 no 748 0.227271310545579 1165 3602145
SGTC_3036 9090181 49.47 µM 0.746253835262291 0.233398927269727 no 749 0.227757046430321 1109 25236586
SGTC_2471 5466956 24.79 µM 0.745764767535589 0.233553841583676 no 750 0.227904763315501 1093 724419
SGTC_2232 chlorophetanol 41.5365 µM 0.745446507014555 0.233654682596967 no 751 0.228000918931366 1196 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2294 7971431 200 µM 0.743691141818067 0.234211304501904 no 752 0.228531674846753 1043 5741572
SGTC_1168 k815-0004 80.5 µM 0.742854047821374 0.234477003204052 no 753 0.228785024545973 1124 642433
SGTC_502 l-744,832 89.3 µM 0.741121830060374 0.235027348810728 no 754 0.229309787250542 1113 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2428 5615643 7.78 µM 0.740898881851918 0.235098233832018 no 755 0.229377376760134 1099 2253075
SGTC_1357 1503-1303 39.5 µM 0.73854724652248 0.235846640671564 no 756 0.230090983842888 1170 292895
SGTC_503 tyrphostin 8 294 µM 0.738509847610036 0.235858553458256 no 757 0.230102342621425 1108 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2558 carylophyllene oxide 100 µM 0.736602322805933 0.236466602726617 no 758 0.230682110999006 1220 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_3290 9121031 71.43 µM 0.73379123246954 0.237364246125811 no 759 0.231537992447428 1108 17014854
SGTC_3334 9142812 21.919 µM 0.733756853451722 0.237375235676476 no 760 0.231548470635027 1107 45283678
SGTC_2835 9006588 71.43 µM 0.733609987890943 0.237422185670147 no 761 0.2315932359402 1103 2345538
SGTC_2912 7964298 10.93 µM 0.733353167279426 0.237504298353733 no 762 0.231671527647237 1170 2975850
SGTC_29 0299-0004 12.984 µM 0.731922503616752 0.237962006424885 no 763 0.232107934974337 1047 16871 A napthoquinone isolated from Swertia calycina.
SGTC_733 4069-0007 56.1 µM 0.730623916157091 0.23837787806405 no 764 0.232504449852285 1155 5717425 YNL287W SEC21
SGTC_172 1112-0046 2.638 µM 0.729240948808177 0.238821209589304 no 765 0.232927143413133 1053 2802135 YIL048W NEO1
SGTC_1734 st037168 69.4 µM 0.729222425221639 0.238827150670009 no 766 0.232932807903384 1070 708907
SGTC_1245 0418-0076 17.2 µM 0.729177750581222 0.238841479526053 no 767 0.232946469668925 1116 6790114
SGTC_1211 1056-0033 32.3 µM 0.728004835840949 0.239217846067592 no 768 0.23330531302688 1140 6741922
SGTC_1398 3558-0053 112 µM 0.726432600930454 0.239722854957185 no 769 0.233786805828907 1077 4532369
SGTC_478 N-arachidonylglycine 10 µM 0.726129669071312 0.239820224826814 no 770 0.233879641152948 1074 5283389
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.724914994912651 0.240210868070221 no 771 0.234252090574751 1166 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_383 2324-0395 7.37 µM 0.724577236070402 0.240319554022968 no 772 0.234355714180121 1152 3146421
SGTC_507 nimesulide 162 µM 0.724210454908033 0.240437609279747 no 773 0.234468270489566 1150 4495 A COX2 inhibitor.
SGTC_1044 1222-0021 1.78 µM 0.72420924710342 0.240437998086026 no 774 0.234468641185127 1093 4306703
SGTC_3238 9133470 49.47 µM 0.724138510764291 0.240460769529266 no 775 0.234490351923512 1150 3534688
SGTC_1573 oleylamine 1.06 µM 0.72347040726253 0.240675903341726 no 776 0.234695464322122 1168 5356789 An amine of the fatty acid oleic acid.
SGTC_756 0508-1999 28.3 µM 0.723333715591275 0.240719931883706 no 777 0.234737441832592 1152 6753853
SGTC_2648 atorvastatin 78.68 µM 0.722805909959391 0.240889979808559 no 778 0.234899567957103 1155 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1393 3470-5649 58.2 µM 0.722770206956397 0.240901484927844 no 779 0.234910537087287 1063 4108395
SGTC_399 oxolinic acid 75 µM 0.720824463262815 0.241528943187581 no 780 0.235508761071557 1123 4628 A DNA gyrase inhibitor.
SGTC_997 3996-0078 137 µM 0.720012304980592 0.241791108135836 no 781 0.235758709692246 1199 735687
SGTC_925 2064-1272 59.6 µM 0.718898513522354 0.242150891331373 no 782 0.236101726209413 1109 6815817
SGTC_134 0269-0018 6.916 µM 0.71830112660787 0.242343982139205 no 783 0.236285817837121 1074 4378915
SGTC_684 1140-0066 328 µM 0.717478971525495 0.242609860164562 no 784 0.23653930354286 1183 6813534
SGTC_2097 5376186 200 µM 0.71725929420316 0.242680928690195 no 785 0.236607059472781 1118 742755
SGTC_533 1222-0222 6.71 µM 0.716369573387213 0.242968880395399 no 786 0.236881588694073 1207 3982874
SGTC_2629 bisabolol 100 µM 0.716178084169372 0.243030878657062 no 787 0.236940696847248 1157 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1510 1123-0200 71.5 µM 0.716151623321776 0.243039446530559 no 788 0.236948865317153 1196 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_554 4483-2211 187 µM 0.715886915035066 0.243125166574722 no 789 0.237030589347135 1129 747107
SGTC_2612 dictamnine 15.46 µM 0.715556298841137 0.243232252423357 no 790 0.237132683037317 1114 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2961 9083290 32.55 µM 0.714684362063068 0.243514793054746 no 791 0.237402051401619 1121 17741490
SGTC_3354 9151612 71.43 µM 0.714023995052272 0.243728894966545 no 792 0.237606171036841 1173 27261949
SGTC_606 k015-0008 38.6 µM 0.713888238679033 0.243772922018693 no 793 0.237648145302331 1212 1970475
SGTC_1013 4112-3890 241 µM 0.713550752546036 0.243882390503518 no 794 0.237752509650794 1097 705171
SGTC_1449 4112-4002 201 µM 0.713285548791035 0.243968431768223 no 795 0.237834539004387 1149 2059539
SGTC_1562 morin hydrate 59.1 µM 0.713056862240696 0.244042638736977 no 796 0.237905285794895 1166 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1653 st012112 65 µM 0.712407635050191 0.244253374129396 no 797 0.238106194489043 1147 720429
SGTC_2698 st077697 67.5 µM 0.712197012530694 0.244321762050611 no 798 0.238171393329854 1126 3154499
SGTC_1760 st045453 10.4495 µM 0.712182877789553 0.244326351889306 no 799 0.238175769132153 1189 3323419 YIL048W NEO1
SGTC_237 nikkomycin 200 µM 0.711222891637531 0.244638187703677 no 800 0.238473062615161 1195 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2552 juarezic acid 87.02 µM 0.709796657205077 0.245101872127063 no 801 0.238915121165948 1255 1549512
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.709496111375591 0.245199643129815 no 802 0.239008331884656 1145 15053
SGTC_2818 7996756 12.99 µM 0.707718970544006 0.245778195775514 no 803 0.239559897140059 1179 2241621
SGTC_813 k007-0158 173 µM 0.707478508011461 0.245856535206004 no 804 0.239634582027769 1199 6523916
SGTC_2709 st078560 56 µM 0.706971785497843 0.246021662394658 no 805 0.239792005791408 1190 17250903
SGTC_742 0kpi-0133 140 µM 0.706710306205228 0.246106894705533 no 806 0.239873261772078 1186 2728852
SGTC_2661 dactinomycin 12.96 µM 0.706467054731495 0.246186199658381 no 807 0.239948866851075 1185 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2791 5663188 71.43 µM 0.70571492527768 0.246431495903899 no 808 0.240182718671111 1151 54690634
SGTC_2719 novobiocin 32.65 µM 0.704587351720486 0.246799483092895 no 809 0.240533536009494 1175 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2449 5812982 45.77 µM 0.702598752245499 0.247449185043418 no 810 0.241152920161226 1133 776185
SGTC_3059 1327-0034 3 µM 0.701854241872357 0.247692661448536 no 811 0.241385033832384 1156 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1786 berberine 21.6 µM 0.701037825518218 0.247959800186356 no 812 0.241639704865564 1172 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1384 3089-0840 101 µM 0.699434671824403 0.248484813477941 no 813 0.24214021309303 1174 1069836
SGTC_1196 1588-0294 184 µM 0.699133158334466 0.248583621608406 no 814 0.242234409046685 1172 6144269
SGTC_288 1315-0019 35.1 µM 0.696878325054875 0.249323209705346 no 815 0.242939471698006 1221 6811474
SGTC_1713 st033146 12.748 µM 0.696682878583113 0.249387371437739 no 816 0.243000637999131 1191 674619
SGTC_2754 granisetron 64.02 µM 0.695928757933448 0.249635018583614 no 817 0.243236723239152 1188 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_3154 9100113 49.47 µM 0.695836272364433 0.249665399089151 no 818 0.243265685332553 1192 25237525
SGTC_752 1896-0090 130 µM 0.694693593199031 0.250040918749832 no 819 0.243623671985888 1198 772567
SGTC_1469 k284-2957 126 µM 0.69461854489594 0.250065592422797 no 820 0.243647193603272 1224 23884841
SGTC_2102 5377816 72.7585 µM 0.69400717532582 0.250266640854831 no 821 0.243838854552634 1221 1379702
SGTC_638 3970-0837 4.09 µM 0.693637758345379 0.250388164883889 no 822 0.243954704140157 1197 4118451 YLR208W SEC13
SGTC_1548 st061468 90.8 µM 0.693555073674859 0.25041536925498 no 823 0.243980638213958 1206 390799
SGTC_2923 7992654 58.14 µM 0.693538626510251 0.250420780780619 no 824 0.243985797049832 1210 2985126
SGTC_951 1171-0579 82.7 µM 0.693081897008414 0.250571080885718 no 825 0.244129078835248 1209 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2182 6325192 200 µM 0.692333241817141 0.250817550951595 no 826 0.244364039492699 1147 736248
SGTC_2216 7189485 200 µM 0.691177105022833 0.251198422921706 no 827 0.244727124942035 1202 731273
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.689645778156725 0.251703366130492 no 828 0.245208485845413 1223 676296 Flavone; oxidizing agent.
SGTC_345 1362-0200 395 µM 0.687276377449431 0.252485712816233 no 829 0.245954290979676 1185 1419823
SGTC_454 lyso-paf C-16 6.67 µM 0.685418447992651 0.253100073184151 no 830 0.246539953053031 1156 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2785 7756463 72.73 µM 0.685342029799314 0.253125359166452 no 831 0.246564057810618 1203 2201551
SGTC_645 0845-0943 5.41 µM 0.682668304083397 0.254010902978423 no 832 0.247408231234513 1198 1885106
SGTC_1704 st028805 70.8 µM 0.679137575477829 0.255182773716542 no 833 0.248525347983754 1217 2876101
SGTC_78 0336-0123 156.75 µM 0.678658948305035 0.255341850364801 no 834 0.248676991425331 1104 6765896
SGTC_1625 st003711 30.1 µM 0.67759351259139 0.255696144870261 no 835 0.249014730275531 1269 24207034 YER133W GLC7
SGTC_1208 2323-2347 50.3 µM 0.677499285403306 0.255727491044175 no 836 0.249044611659178 1225 5412760
SGTC_170 4197-0004 226 µM 0.676548793837279 0.25604379935144 no 837 0.24934613877846 1222 218692
SGTC_983 1491-0821 12.2 µM 0.676507075434569 0.256057687238811 no 838 0.249359377669478 1194 46495113
SGTC_1604 st002052 72.4 µM 0.676130681346204 0.256183005069509 no 839 0.249478839218348 1258 6254834 YHR062C RPP1
SGTC_1077 5-fluorocytosine 377 nM 0.67612883257093 0.256183620685475 no 840 0.249479426065518 1210 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1326 1431-2094 10.8 µM 0.675229473276533 0.256483186018466 no 841 0.249764991988005 1206 616278
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.674458884919698 0.256740004457582 no 842 0.250009808363839 1311 6728940
SGTC_1041 0206-0046 107 µM 0.673945126563041 0.256911302027072 no 843 0.250173100414625 1228 50494
SGTC_508 roscovitine 141 µM 0.673392938961235 0.257095478980694 no 844 0.25034866980015 1264 160355 A CDKinase inhibitor.
SGTC_2123 5259487 200 µM 0.673066571434771 0.257204368060229 no 845 0.25045246984895 1209 2173474
SGTC_2260 7964312 200 µM 0.671955603492485 0.257575210429056 no 846 0.250805980208881 1270 231951
SGTC_43 0570-0105 72.5 µM 0.669538222147867 0.258383093511262 no 847 0.251576103612612 1270 1114046 YDL195W SEC31
SGTC_366 0181-0206 4.31 µM 0.669506590686331 0.258393673365475 no 848 0.251586188959668 1256 274874
SGTC_2623 humulene 100 µM 0.66943203275742 0.258418611830796 no 849 0.251609961788422 1182 6187145 An anti-inflammatory.
SGTC_2341 7987486 176.74 µM 0.668090908778466 0.258867409750841 no 850 0.252037782326717 1239 1258686
SGTC_1525 8-methoxypsoralen 92.5 µM 0.667257517087091 0.259146501574769 no 851 0.252303828738203 1281 4114 Related to psoralen; DNA damaging agent.
SGTC_2976 9009005 19.48 µM 0.666942688749552 0.259251973876089 no 852 0.252404370956409 1266 2993148
SGTC_1967 st070177 51.4 µM 0.665606985506332 0.259699701464534 no 853 0.252831170116817 1288 5729214
SGTC_2696 st077691 74.316 µM 0.665399801454321 0.25976918527293 no 854 0.252897405951162 1234 757133
SGTC_3267 9137951 49.47 µM 0.663158963637635 0.260521312904857 no 855 0.25361437516419 1239 16643986
SGTC_3106 9121286 49.47 µM 0.661283442488762 0.261151684433752 no 856 0.254215278912689 1271 15943471
SGTC_2465 5809242 33.21 µM 0.660670754427923 0.261357781527402 no 857 0.254411741502205 1248 2731748
SGTC_2867 9039098 71.43 µM 0.660283581139667 0.261488062625708 no 858 0.254535932263965 1234 6463460
SGTC_68 0986-0284 82.829 µM 0.659294105410826 0.26182116570352 no 859 0.254853463444823 1224 423278 YIL048W NEO1
SGTC_2524 avocatin b 10.57 µM 0.658295337509827 0.262157617543481 no 860 0.255174186701028 1193 6710748
SGTC_1052 3253-3998 198 µM 0.657776950619998 0.262332332218589 no 861 0.255340733697725 1246 5450317
SGTC_1616 st002734 56.1 µM 0.65773639042005 0.26234600495238 no 862 0.255353767248177 1231 4026101
SGTC_3324 9138759 60.749 µM 0.657116508551847 0.262555010855498 no 863 0.255553002364065 1261 45595710
SGTC_670 4204-0025 119 µM 0.656256414996492 0.262845150154985 no 864 0.255829577925909 1266 719039
SGTC_2545 solidagenone 89.61 µM 0.653676342757279 0.263716480266949 no 865 0.25666017391886 1113 6708572 An anti ulcer agent
SGTC_1322 1348-1070 12 µM 0.653210412079947 0.263873989131633 no 866 0.256810319325153 1246 6758089
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.652426890480547 0.26413896838329 no 867 0.25706291093284 1335 94937 An inhibitor of serotonin biosynthesis.
SGTC_2287 7945887 168.79 µM 0.651681264694999 0.264391257456793 no 868 0.25730340562994 1285 1245853
SGTC_1614 st002383 48.6 µM 0.651087208193343 0.264592349479168 no 869 0.257495096722233 1265 1947235
SGTC_1518 st038567 90.8 µM 0.648879379121547 0.265340395420538 no 870 0.258208172146885 1270 77966
SGTC_2081 5214970 32.255 µM 0.64882285328324 0.265359561314604 no 871 0.258226442056625 1234 2063512
SGTC_1619 st003326 88.7 µM 0.644989031570718 0.266661111193778 no 872 0.259467146854266 1253 2849032
SGTC_694 1315-0438 43.2 µM 0.644899911064025 0.266691405187546 no 873 0.259496024686288 1244 6793154
SGTC_2458 5808907 16.39 µM 0.6429828416148 0.267343479613489 no 874 0.260117616792326 1323 2731747
SGTC_274 sirtinol 40.1 µM 0.640118127409032 0.268319383869757 no 875 0.261047902381387 1268 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_367 0335-0881 7.1 µM 0.639942004889089 0.268379440844168 no 876 0.261105152064778 1258 23828853
SGTC_153 4077-0274 519.67 µM 0.639500367351789 0.268530066949837 no 877 0.261248737375492 1389 3121976
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.638685871786069 0.26880797244467 no 878 0.261513652748159 1268 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2822 7994718 71.43 µM 0.634470603266583 0.270248524393196 no 879 0.262886872814498 1279 1018011
SGTC_1059 3448-6867 171 µM 0.634041124680754 0.270395513460364 no 880 0.263026991959095 1265 3934407
SGTC_913 3487-1245 167 µM 0.633242825259488 0.270668837598123 no 881 0.263287541785834 1247 4016153
SGTC_724 3910-0327 137 µM 0.632966439346882 0.270763499574365 no 882 0.263377779625749 1278 2885483
SGTC_94 0334-0113 514.748 µM 0.631572447035728 0.271241192695481 no 883 0.263833147756061 1248 6795178
SGTC_539 4859-0462 2.54 µM 0.630295802900282 0.271679041202311 no 884 0.264250534249685 1291 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2339 9000433 200 µM 0.628755027284611 0.272207946597002 no 885 0.264754723401113 1263 2988954
SGTC_1156 4092-0367 4.88 µM 0.628155261998479 0.272413967614331 no 886 0.264951117217811 1298 1357585
SGTC_164 4100-3994 89.624 µM 0.627704129181073 0.272568983990221 no 887 0.265098889935466 1333 4615967
SGTC_470 aa-861 153 µM 0.626926924813625 0.272836146377531 no 888 0.265353568546987 1264 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2357 9067248 200 µM 0.62612409941278 0.273112252256379 no 889 0.265616773126471 1310 9150235
SGTC_2825 7998094 58.44 µM 0.625841680993886 0.273209413868342 no 890 0.265709394867791 1294 2987815
SGTC_1215 3852-0577 11.2 µM 0.625647161695666 0.273276345129595 no 891 0.265773198798811 1389 2884876
SGTC_807 1315-0151 48 µM 0.623613506401926 0.273976582284671 no 892 0.266440719180879 1328 4011080
SGTC_61 0978-8327 98.565 µM 0.62090639816456 0.274910079553512 no 893 0.267330605593788 1326 6150059 YHR072W ERG7
SGTC_942 3253-1115 227 µM 0.62039260831598 0.275087427489211 no 894 0.267499668840201 1375 46497897
SGTC_217 ketoconazole 989 nM 0.62031812991592 0.275113140322369 no 895 0.267524180532145 1257 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2419 paclitaxel 166.5 µM 0.619931677026549 0.275246577853927 no 896 0.267651384772343 1247 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2184 6075246 200 µM 0.619811299483681 0.27528814927746 no 897 0.267691014285796 1334 2267320
SGTC_1482 3346-2049 8.48 µM 0.618381830775483 0.275782040992041 no 898 0.268161835887497 1322 3826804
SGTC_101 0490-5701 117.494 µM 0.617817233518766 0.275977233292336 no 899 0.268347911032918 1224 4661669
SGTC_260 nsc-65238 3.989 µM 0.617518988228852 0.276080369895013 no 900 0.268446230376152 1279 3246252
SGTC_1348 1493-0373 93.8 µM 0.617378009803652 0.276129128418577 no 901 0.268492711533294 1329 3010129
SGTC_2051 5263410 176 µM 0.617083422281351 0.276231027528474 no 902 0.268589851290216 1355 227584
SGTC_2394 5221648 200 µM 0.615296460629929 0.276849540536561 no 903 0.269179477278345 1413 788586
SGTC_1098 clofazimine 15.1 µM 0.613773038563274 0.277377370820197 no 904 0.269682657988525 1363 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_898 1000-0849 28.3 µM 0.612576121013715 0.277792419746708 no 905 0.270078325689164 1304 6751807
SGTC_102 gallobenzophenone 83.616 µM 0.612054464771085 0.27797340662704 no 906 0.270250861580869 1396 70837
SGTC_745 0469-0705 296 µM 0.611115894244489 0.278299185348569 no 907 0.270561429068535 1409 3486736
SGTC_2932 9016711 44.54 µM 0.61089488463203 0.278375925060026 no 908 0.270634585779693 1327 7117328
SGTC_1725 st036284 20.55 µM 0.610645617289013 0.278462488890217 no 909 0.270717107975949 1362 707914
SGTC_701 4424-0219 185 µM 0.609562566660511 0.278838755399355 no 910 0.271075807453806 1354 2911779
SGTC_2853 9015042 58.44 µM 0.609203804450793 0.278963448797151 no 911 0.271194679459346 1250 6457456
SGTC_2181 6316240 54.2555 µM 0.609118063894875 0.278993253279097 no 912 0.271223092519091 1304 12779990
SGTC_2106 5357045 167.29 µM 0.608915552498674 0.279063654903757 no 913 0.271290207473852 1372 668842
SGTC_87 0100-0052 35.5 µM 0.608574426409457 0.279182264454252 no 914 0.271403279883257 1381 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_840 0245-0196 390 µM 0.608548607401851 0.279191242721353 no 915 0.271411839015885 1386 3827528
SGTC_2586 curcumin 80 µM 0.607802359962755 0.279450802437817 no 916 0.271659281947404 1365 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2975 9084847 53.72 µM 0.607405949682888 0.279588729471678 no 917 0.271790770499743 1362 27211724
SGTC_1404 3909-7820 48.3 µM 0.605409779539394 0.280283778885299 no 918 0.27245337733668 1318 23741373
SGTC_1859 st055998 20 µM 0.605214105800054 0.280351955825303 no 919 0.272518372240812 1378 676301
SGTC_382 3229-0966 23.2 µM 0.604045047651124 0.280759448061251 no 920 0.272906846406819 1386 5722370
SGTC_1460 k062-0059 9.15 µM 0.602405716968182 0.281331342624905 no 921 0.273452052721454 1300 1373085
SGTC_2647 atorvastatin 60.16 µM 0.600595395512005 0.281963541394506 no 922 0.27405475276254 1360 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1169 aniline yellow 25.8 µM 0.600315438569158 0.282061368759309 no 923 0.274148015806148 1341 6051 A DNA damaging agent.
SGTC_467 ro 31-8220 72.8 µM 0.595595472159968 0.283713156347259 no 924 0.275722751098831 1320 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2340 7987427 183.45 µM 0.595273350550533 0.283826053870573 no 925 0.275830383264251 1365 2239331
SGTC_2010 4012422 159 µM 0.59422024345852 0.284195297978693 no 926 0.27618240741011 1369 952393
SGTC_2108 5365811 200 µM 0.594025902075376 0.284263463733204 no 927 0.276247394372587 1404 780283
SGTC_1569 carminic acid 40.6 µM 0.591117485199002 0.285284531227041 no 928 0.277220852503867 1364 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.590061568053596 0.285655667393388 no 929 0.277574686704088 1321 803109
SGTC_2844 9010103 25.97 µM 0.58971113059494 0.285778890704671 no 930 0.277692165841844 1360 2480525
SGTC_2581 avocatin a 64 µM 0.588250246921492 0.286292849193838 no 931 0.278182167644628 1360 6710728 A skin care supplement.
SGTC_1179 1021-1431 9.29 µM 0.587787328071981 0.286455801777623 no 932 0.278337525341725 1366 2840958
SGTC_57 miconazole 162.5 nM 0.584463458328668 0.287627131530938 no 933 0.279454271639227 1291 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2100 5377183 190 µM 0.584293635366801 0.287687037779654 no 934 0.279511386755596 1395 2844202
SGTC_2539 epi(13)torulosol 80 µM 0.583995987723895 0.287792049308023 no 935 0.279611505734169 1325 6708597
SGTC_1652 st011932 78 µM 0.582466468242471 0.288331956571194 no 936 0.280126260688431 1382 1551076
SGTC_1030 k029-0042 36.7 µM 0.582051393164427 0.288478556862254 no 937 0.280266032076518 1413 6080581
SGTC_822 1487-0950 154 µM 0.581219273261107 0.28877255889405 no 938 0.28054633984209 1379 1958375
SGTC_1989 st071868 50.2 µM 0.579812090284267 0.289270061172493 no 939 0.281020671738406 1388 16414057
SGTC_3260 9137109 49.47 µM 0.579537980683836 0.289367018065525 no 940 0.28111311341472 1301 17478346
SGTC_763 3453-1109 128 µM 0.579186363433204 0.289491412989088 no 941 0.281231715542594 1374 1560353
SGTC_39 0986-0283 58.349 µM 0.578792913981428 0.289630637048832 no 942 0.281364456503042 1438 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1707 st032323 6.317 µM 0.578569703228068 0.289709635263389 no 943 0.281439776212356 1334 3132057 YMR211W DML1
SGTC_1667 st014849 34.6 µM 0.576618931719488 0.290400477622309 no 944 0.282098453676264 1396 5348460
SGTC_3330 9141424 71.43 µM 0.575831256266557 0.290679641863964 no 945 0.282364622268474 1412 27261020
SGTC_471 1-acyl-paf 4 µM 0.575619044834524 0.290754874303329 no 946 0.282436352682321 1310 16759367
SGTC_1318 1280-3875 124 µM 0.5755064247173 0.290794803683059 no 947 0.282474423406645 1368 373245
SGTC_269 exalamide 29 µM 0.574644596770917 0.29110044899178 no 948 0.282765842139421 1425 3316 A derivative of salicylamide.
SGTC_2947 9072639 7.68 µM 0.574511601545815 0.291147628804238 no 949 0.282810826041598 1346 16488146
SGTC_2282 7944268 200 µM 0.573806723523076 0.291397742585487 no 950 0.283049299221654 1440 2970414
SGTC_546 peri-Naphthalide 147 µM 0.573324690818005 0.291568841255144 no 951 0.283212435287874 1364 223824 A penicillin ester.
SGTC_1733 st037357 54.9 µM 0.572967176286674 0.291695772147636 no 952 0.283333459344512 1319 1272339 YGL099W LSG1
SGTC_283 0987-0079 11.7 µM 0.572156633084868 0.291983640331016 no 953 0.28360793224241 1400 411556
SGTC_279 1273-0055 2.93 µM 0.571158160525379 0.292338434223608 no 954 0.283946218353494 1418 2847562
SGTC_1148 3909-7663 27.7 µM 0.570204942828945 0.292677334347718 no 955 0.28426935201001 1435 4084526
SGTC_3070 9117005 49.47 µM 0.56888282206783 0.293147693449888 no 956 0.28471783182016 1441 8779016
SGTC_406 estrone 100 µM 0.568777050022917 0.293185338164687 no 957 0.28475372559857 1473 5870 A steroid.
SGTC_2367 9070478 135.38 µM 0.568241813039461 0.293375865613382 no 958 0.284935391552088 1404 572802
SGTC_656 4090-1979 187 µM 0.564939600644177 0.294552615677669 no 959 0.286057423533257 1436 22330961
SGTC_3343 9148379 18.9835 µM 0.563187615590729 0.295177822091635 no 960 0.286653567529856 1478 1955036
SGTC_2929 9013348 24.6 µM 0.563057607040663 0.295224240766982 no 961 0.286697828716573 1402 2995952
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.561658621465518 0.295723951609936 no 962 0.287174315864296 1369 2374 Ca(2+)-ATPase inhibitor.
SGTC_643 k048-0106 28.4 µM 0.560968401438799 0.295970637946074 no 963 0.287409539205331 1431 6763920
SGTC_1696 st025591 34.7925 µM 0.560362333231424 0.296187326082612 no 964 0.287616159165035 1406 2787147
SGTC_2205 7238770 200 µM 0.559895896408546 0.296354141221046 no 965 0.287775223975339 1414 279867
SGTC_792 4534-1957 155 µM 0.559761818481914 0.296402100438664 no 966 0.287820955069522 1409 1717904
SGTC_398 bronopol 33.3 µM 0.559576621484291 0.296468350624216 no 967 0.287884127422872 1400 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1879 gemcitabine 100 µM 0.559097290239281 0.296639852424442 no 968 0.288047661998221 1396 60750 A nucleoside analog which inhibits DNA replication.
SGTC_173 1273-0061 2.693 µM 0.557469154619287 0.297222728447207 no 969 0.288603464023001 1341 2847414 YPL266W DIM1
SGTC_2464 5717415 7.67 µM 0.55604262732618 0.297733858090884 no 970 0.289090857204039 1330 5285744
SGTC_1557 sumaresinolic acid 42.3 µM 0.555757982340331 0.2978358953409 no 971 0.289188156488003 1350 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1047 2043-3044 82 µM 0.555464754979564 0.297941025804713 no 972 0.289288405554184 1361 669592
SGTC_2810 7959871 45.46 µM 0.555172288576956 0.298045900290963 no 973 0.28938841072884 1457 2974535
SGTC_659 k018-0002 107 µM 0.554338370664728 0.298345024271878 no 974 0.289673647519519 1406 6797879 YHR007C ERG11
SGTC_3293 9120939 62.045 µM 0.551568129205708 0.299339681570929 no 975 0.290622138576938 1446 934087
SGTC_216 k038-0035 28.382 µM 0.551271922487834 0.299446123768333 no 976 0.290723641441825 1373 4444231 YPR107C YTH1
SGTC_2470 5664817 21.68 µM 0.549927527967073 0.299929448907791 no 977 0.291184541122017 1440 2859561
SGTC_2872 9044037 25.97 µM 0.54831251828078 0.300510529636805 no 978 0.291738666638056 1441 6465195
SGTC_156 3474-0145 5.642 µM 0.548131948426859 0.300575530286599 no 979 0.291800652440285 1387 2265471
SGTC_2373 9071805 200 µM 0.546482933376451 0.301169428090208 no 980 0.292367008023312 1474 10149009
SGTC_3008 9078912 71.4286 µM 0.544682087188716 0.301818611580531 no 981 0.292986093388777 1396 16648731
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.544655531240292 0.301828189386115 no 982 0.292995227201211 1398 229346 A bile salt which induces apoptosis.
SGTC_1233 0325-0408 14.2 µM 0.543692536558698 0.302175600272048 no 983 0.293326534599137 1478 12874
SGTC_812 4251-0442 148 µM 0.542925741665865 0.30245235822474 no 984 0.293590465779836 1407 5723007
SGTC_2058 5236698 133 µM 0.542467617476324 0.302617762414012 no 985 0.293748204803934 1428 766665
SGTC_987 1497-1013 404 µM 0.54240149299154 0.302641639782848 no 986 0.29377097569339 1412 1676435
SGTC_2683 piperine 63.03 µM 0.542095875717929 0.302752008301844 no 987 0.293876229877469 1399 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2723 salbutamol 83.58 µM 0.541209282351836 0.303072288486513 no 988 0.29418167011124 1444 9884233 β2-adrenoceptor agonist
SGTC_1881 5652484 16 µM 0.540445685606145 0.303348257803143 no 989 0.294444854292471 1466 2255129
SGTC_374 0880-0231 82.3 µM 0.539058859823352 0.303849753505493 no 990 0.294923120720136 1393 6833587
SGTC_2973 9094665 17.96 µM 0.537709455384881 0.304338071791574 no 991 0.295388825204734 1547 25237061 YIL048W NEO1
SGTC_430 0958-0115 16.4 µM 0.53753113252913 0.304402628843447 no 992 0.295450393027682 1440 6833180
SGTC_1499 4480-0877 67.3 µM 0.536654459938927 0.304720093468719 no 993 0.295753159170458 1402 2861909
SGTC_3094 9117742 49.47 µM 0.535338395774475 0.305196948690432 no 994 0.296207940267555 1371 17149698
SGTC_1183 1254-0324 198 µM 0.534804738278493 0.305390405448408 no 995 0.296392443116961 1489 5799357
SGTC_863 0466-0191 129 µM 0.533738221670604 0.30577719238682 no 996 0.296761330549227 1436 765160 YPR165W RHO1
SGTC_3147 9097027 49.47 µM 0.53347209007737 0.30587374248491 no 997 0.29685341306921 1539 25236841
SGTC_1957 st077035 62.4 µM 0.533236038395144 0.305959391159222 no 998 0.296935098769521 1490 705593
SGTC_407 eburnamonine 100 µM 0.529628082564776 0.307269815347626 no 999 0.298184909869806 1398 3195
SGTC_344 k064-0035 6.43 µM 0.528789646332654 0.307574692321712 no 1000 0.298475690450065 1401 5088750
SGTC_245 methotrexate 289.6 µM 0.527932851558504 0.307886382301088 no 1001 0.298772971224266 1461 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2022 5136654 200 µM 0.527688963240707 0.307975130829721 no 1002 0.298857617380059 1459 1713771
SGTC_1103 duloxetine 36.1 µM 0.525091859047915 0.308920886956758 no 1003 0.299759667570895 1560 60835 A selective serotonin reuptake inhibitor.
SGTC_2511 berberine 10.47 µM 0.524819314056906 0.309020210016176 no 1004 0.29985440185713 1440 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1413 3910-0535 34.4 µM 0.524483707823131 0.309142533549933 no 1005 0.299971074303962 1510 2876951
SGTC_1078 idebenone 36.1 µM 0.522955883118235 0.309699670474894 no 1006 0.30050247716929 1447 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_103 0844-0104 51.839 µM 0.522189017307682 0.309979480938115 no 1007 0.300769366024346 1483 5375804
SGTC_75 0159-0059 199.013 µM 0.521962034491003 0.310062322505522 no 1008 0.300848382339733 1548 5377270
SGTC_1258 0671-0043 57.1 µM 0.521456320260476 0.310246926914234 no 1009 0.30102446313859 1422 4298767
SGTC_563 tetrahydrosecaminediol 614 µM 0.521415831031267 0.310261709049591 no 1010 0.301038562784292 1538 334274 A psychoactive constituent of the cannabis plant.
SGTC_704 1310-0270 142 µM 0.521161341688347 0.310354627095601 no 1011 0.301127190934557 1397 5718033
SGTC_2866 9034245 58.44 µM 0.51990340133989 0.310814098539891 no 1012 0.30156545230221 1516 6462273
SGTC_1546 5-methoxyflavanone 78.7 µM 0.519559127821074 0.310939898306619 no 1013 0.301685445808105 1513 147795
SGTC_2881 9058953 51.95 µM 0.519489554917103 0.310965323379444 no 1014 0.3017096974392 1395 17122249
SGTC_3299 9121982 43.1275 µM 0.519019880791914 0.311136987062714 no 1015 0.301873438753823 1455 17594604 YPL160W CDC60
SGTC_2801 7907800 81.82 µM 0.518712432690021 0.311249380153529 no 1016 0.301980645236365 1461 6620925
SGTC_904 1141-0088 396 µM 0.518136039488191 0.311460138302293 no 1017 0.302181678358708 1370 1378119
SGTC_1291 0993-0025 5.79 µM 0.517098829192779 0.311839549830648 no 1018 0.302543585444424 1550 4353356
SGTC_1372 2752-0194 270 µM 0.515648113293275 0.312370556782835 no 1019 0.303050099999045 1400 823334
SGTC_1058 3448-5425 97.3 µM 0.513757379645343 0.313063209009102 no 1020 0.303710814683859 1397 7279705
SGTC_1160 4092-0570 10.5 µM 0.512153546627676 0.313651275651809 no 1021 0.304271775700215 1435 4994975
SGTC_1921 5740136 50 µM 0.512055435982519 0.313687264615234 no 1022 0.304306106120005 1577 1774243
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.511503318760347 0.313889825405281 no 1023 0.304499332561782 1374 4000243
SGTC_2954 9074818 52.69 µM 0.510776118600807 0.314156706231775 no 1024 0.304753916680492 1512 16648742
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.509464195022903 0.314638425042239 no 1025 0.305213444666738 1543 5024745
SGTC_583 1488-1091 88.9 µM 0.505653123919288 0.316039581808294 no 1026 0.306550090545266 1526 4303273
SGTC_2377 9073351 62.6 µM 0.503476075142469 0.316841172389319 no 1027 0.307314798550566 1439 7337946 YHR072W ERG7
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.499828401893444 0.318186175478781 no 1028 0.308597955060942 1487 97141
SGTC_2018 5133068 143 µM 0.498608612774718 0.318636483731618 no 1029 0.30902756820145 1467 785362
SGTC_1842 st055362 61.2 µM 0.498558321186268 0.318655055580371 no 1030 0.309045286653149 1534 676032
SGTC_2301 7769476 200 µM 0.498037074419027 0.318847570179728 no 1031 0.309228955562608 1555 977820
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.497463555615476 0.319059447154357 no 1032 0.30943109838555 1522 279621
SGTC_1841 st054148 70 µM 0.497436861056245 0.319069310455522 no 1033 0.309440508573082 1428 675442
SGTC_2878 9043973 25.97 µM 0.497035227655547 0.31921772436376 no 1034 0.309582104774368 1550 6465167
SGTC_1975 st070967 30.8 µM 0.496810557909975 0.319300758273739 no 1035 0.309661324617418 1564 261391
SGTC_2046 4110841 106 µM 0.49615002239833 0.319544932841707 no 1036 0.30989428443947 1494 44119630 YMR134W ERG29
SGTC_126 0417-1624 672.48 µM 0.49484836356881 0.320026335013359 no 1037 0.310353581155398 1536 41912 YDL195W SEC31
SGTC_129 0088-0017 176.636 µM 0.494680964656489 0.32008826741862 no 1038 0.310412670173607 1525 182446
SGTC_2254 7938975 95.19 µM 0.493780246227635 0.320421591326532 no 1039 0.310730692692608 1580 2969277
SGTC_791 1348-1292 225 µM 0.492277539759414 0.32097801210123 no 1040 0.311261577851371 1517 5437054
SGTC_621 3584-0052 32.1 µM 0.491946926616768 0.321100485265127 no 1041 0.311378431604169 1541 2273927
SGTC_326 k292-0812 17.5 µM 0.490811675572795 0.321521178608196 no 1042 0.311779825691792 1527 3579357
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.490811041668981 0.321521413579833 no 1043 0.31178004988558 1472 689007
SGTC_3130 9127414 49.47 µM 0.490602357628658 0.321598771200292 no 1044 0.311853859298674 1486 1494646
SGTC_3123 9126162 49.47 µM 0.487732462975248 0.322663403335588 no 1045 0.312869677249712 1523 25239884
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.487456404288219 0.322765888474916 no 1046 0.3129674651427 1484 521171
SGTC_2092 5303694 80.6725 µM 0.485802395179523 0.323380211237471 no 1047 0.313553637971682 1466 1963699
SGTC_3193 9111931 49.47 µM 0.484698608227522 0.323790441762261 no 1048 0.313945076948559 1537 17087244
SGTC_3286 9117135 37.221 µM 0.484154615530215 0.323992699459385 no 1049 0.314138071644993 1443 3438150
SGTC_798 1287-0182 476 µM 0.483062213739132 0.324399013803225 no 1050 0.314525781362371 1620 1649755
SGTC_2724 maprotiline 69.64 µM 0.480983626335818 0.325172713136585 no 1051 0.31526406795775 1556 4011 A tricyclic antidepressant.
SGTC_3243 9134147 49.47 µM 0.480506665726533 0.325350355670291 no 1052 0.315433582279806 1557 24282180
SGTC_3081 9117243 49.47 µM 0.480389447756032 0.325394019225468 no 1053 0.315475248115123 1604 45595589
SGTC_2751 anetholtrithion 17.25 µM 0.48015798162333 0.325480247124536 no 1054 0.31555753104003 1605 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_405 ebelactone b 50 µM 0.479587566178551 0.325692783417428 no 1055 0.315760344666805 1494 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1471 k673-0312 37 µM 0.478781302532473 0.325993293197151 no 1056 0.316047109756615 1506 24099884
SGTC_70 0141-0289 43.283 µM 0.475831060200079 0.327093867087315 no 1057 0.317097369916629 1613 352408
SGTC_2025 5147754 141 µM 0.47563866737552 0.327165690701036 no 1058 0.317165911380796 1568 315777 YLR208W SEC13
SGTC_2705 st078069 42.8 µM 0.475207445578371 0.32732669660426 no 1059 0.317319560335856 1487 1530061
SGTC_3240 9133527 49.47 µM 0.474078373929078 0.32774841184427 no 1060 0.317722009788109 1498 17617455
SGTC_112 phenothiazine 287.218 µM 0.472680749570193 0.328270737581039 no 1061 0.318220481323201 1633 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1299 1079-1439 3.74 µM 0.472526748857761 0.328328311903173 no 1062 0.318275426809897 1464 323161
SGTC_1806 st050005 60.3 µM 0.47169916938916 0.328637778501184 no 1063 0.318570765044859 1472 5194765
SGTC_2658 polymyxin b sulfate 77.05 µM 0.470701987084004 0.329010822861766 no 1064 0.318926782602574 1508 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_3098 9119039 49.47 µM 0.47066627501411 0.329024185854 no 1065 0.318939535754042 1515 17161528
SGTC_285 1486-1325 46 µM 0.470547852294907 0.329068499659395 no 1066 0.318981827272275 1570 22310230
SGTC_2565 isoliquiritigenin 100 µM 0.470307695465277 0.329158373768335 no 1067 0.319067600119151 1441 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2034 5197015 53.07 µM 0.469686589116589 0.329390856746124 no 1068 0.319289475331787 1609 780676
SGTC_2166 5933061 31.504 µM 0.469008200120418 0.329644856261169 no 1069 0.319531887348655 1682 2877375
SGTC_1385 3091-4834 14.1 µM 0.468631202996845 0.329786043900903 no 1070 0.319666634903469 1575 4072814
SGTC_537 1334-0398 209 µM 0.46728262098124 0.330291294261026 no 1071 0.32014884433864 1624 5846986
SGTC_2133 5320837 200 µM 0.466967181467531 0.330409519343778 no 1072 0.320261679225828 1577 2841355
SGTC_2610 ononetin 44.17 µM 0.46687061500369 0.330445715335209 no 1073 0.320296225038733 1500 259632
SGTC_3205 9113483 49.47 µM 0.466218448769795 0.330690208211429 no 1074 0.320529572604861 1655 17018033
SGTC_2110 5483698 200 µM 0.465709032944479 0.330881235158507 no 1075 0.320711892896234 1532 2848765 YHR062C RPP1
SGTC_582 0987-0078 156 µM 0.465261370818661 0.331049141312853 no 1076 0.320872147205784 1515 1625765
SGTC_2386 9075165 157.42 µM 0.46477573337775 0.331231329427981 no 1077 0.321046033685581 1494 16452277
SGTC_2977 9011197 71.43 µM 0.464086966047742 0.331489790749429 no 1078 0.321292719799264 1592 2704722
SGTC_1067 clotrimazole 1.36 µM 0.463670796719646 0.331645998033685 no 1079 0.32144181154639 1531 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1643 st009866 20.2 µM 0.463376899965427 0.33175632849984 no 1080 0.321547116747852 1583 3156273 YOR207C RET1
SGTC_532 1548-0774 215 µM 0.463009776116953 0.331894169323496 no 1081 0.321678679860568 1642 5932993
SGTC_1590 st077108 57.8 µM 0.462569853747119 0.332059373152508 no 1082 0.321836360628528 1573 5489485
SGTC_2445 5742597 35.57 µM 0.461382658635683 0.332505362810381 no 1083 0.322262045419307 1493 1774255
SGTC_3120 9124077 49.47 µM 0.461202106134042 0.332573211167808 no 1084 0.322326805393999 1551 18774327 YGL155W CDC43
SGTC_989 1501-0895 10.3 µM 0.459908730403615 0.333059398588844 no 1085 0.322790866709931 1597 2830112
SGTC_3233 9132340 49.47 µM 0.459587330425133 0.33318025828081 no 1086 0.322906227407916 1482 17682950
SGTC_1207 2099-0101 141 µM 0.459109953317635 0.333359803804196 no 1087 0.323077604720522 1626 5837381
SGTC_2138 5575593 77.673 µM 0.45883382306733 0.333463676136833 no 1088 0.323176752012578 1502 762213
SGTC_565 1418-0001 44.5 µM 0.458754799679059 0.333493404834529 no 1089 0.323205128452459 1594 2862145
SGTC_3001 9076041 71.4286 µM 0.458224735001462 0.333692842855088 no 1090 0.323395495503566 1526 16004211
SGTC_2640 pentamidine 10.38 µM 0.456649085008882 0.334285962013873 no 1091 0.323961646194692 1618 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1149 3909-7961 23.3 µM 0.454921936077772 0.334936585259086 no 1092 0.324582700461221 1506 735261
SGTC_1084 voriconazole 435 nM 0.454517003686164 0.335089196560713 no 1093 0.324728378166296 1578 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_833 3852-0053 558 µM 0.453593972420234 0.33543717119644 no 1094 0.325060546328609 1609 3123681
SGTC_1949 st076024 69.1 µM 0.452636796056843 0.335798167386491 no 1095 0.325405149085037 1498 2921930
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.452390222007201 0.335891186613008 no 1096 0.325493944905271 1574 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_22 0964-0034 14.468 µM 0.450400115927034 0.336642315003466 no 1097 0.326210980697678 1518 138402
SGTC_1337 1486-1011 40.3 µM 0.450362642231147 0.33665646501571 no 1098 0.326224488656002 1530 X1337
SGTC_1145 3546-0597 10.2 µM 0.449350959015412 0.337038562448294 no 1099 0.326589251221038 1547 875334
SGTC_3155 9099265 49.47 µM 0.448572947980108 0.337332519876197 no 1100 0.326869876074718 1588 25236499
SGTC_49 0717-0965 32.132 µM 0.448438974089274 0.33738314952181 no 1101 0.326918209705319 1625 5889349 YGL099W LSG1
SGTC_2057 5236571 38.335 µM 0.447700721213837 0.337662193106017 no 1102 0.327184600549666 1649 54684039 YBR257W POP4
SGTC_3023 9089636 49.47 µM 0.446719670813233 0.338033147013149 no 1103 0.32753873859299 1629 17249241
SGTC_719 2810-4230 27.3 µM 0.446490618960928 0.338119778563536 no 1104 0.327621443736469 1587 721079
SGTC_1999 st074831 12.5 µM 0.445865962173315 0.338356078606783 no 1105 0.327847035335225 1528 17112523
SGTC_3255 9139072 49.47 µM 0.445663115838098 0.338432826601164 no 1106 0.327920305769582 1556 17646060
SGTC_1715 st032160 10.2275 µM 0.444250294756578 0.338967561023609 no 1107 0.328430816632745 1628 5289825
SGTC_1026 k007-1105 30.6 µM 0.443332727288436 0.339315022341476 no 1108 0.328762543551965 1549 7066794
SGTC_2448 5185112 27.17 µM 0.443261921198745 0.339341840633739 no 1109 0.328788147593651 1541 5718189
SGTC_1846 st056244 14.8 µM 0.442077435532445 0.339790593285776 no 1110 0.329216586057822 1604 5393182
SGTC_881 0833-0569 170 µM 0.441944639338098 0.339840918446475 no 1111 0.329264633560815 1502 5418700
SGTC_1265 0819-1001 68.8 µM 0.441523518963367 0.340000527366715 no 1112 0.329417019394033 1531 3106768
SGTC_3063 1327-0034 4 µM 0.440962164454658 0.340213331049613 no 1113 0.329620194147313 1544 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1699 st031318 29.054 µM 0.439951609970287 0.340596550058244 no 1114 0.329986077564862 1616 5340658
SGTC_1374 2889-5571 141 µM 0.439111800539074 0.340915144978052 no 1115 0.330290264485089 1552 2853281
SGTC_1320 1313-0481 95.3 µM 0.438343438770021 0.341206734528244 no 1116 0.330568670674558 1659 6813365 YLR208W SEC13
SGTC_1658 st012944 20 µM 0.437414464123957 0.341559402530985 no 1117 0.330905398140399 1615 24207260
SGTC_1261 0712-0010 12.7 µM 0.437261694907902 0.34161741178805 no 1118 0.330960785841035 1681 2840123
SGTC_939 1165-0479 45.3 µM 0.436183000967491 0.342027117941819 no 1119 0.331351980191631 1578 1377347
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.436046479274151 0.342078984458824 no 1120 0.331401503674598 1704 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_449 xestospongin c 11.1929 µM 0.435444947180825 0.342307550464887 no 1121 0.331619745596452 1639 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1136 pergolide 1.05886 µM 0.435354788232434 0.342341813419465 no 1122 0.331652461102284 1582 47811 A dopamine receptor agonist.
SGTC_1433 4060-0023 7.6 µM 0.435249600113905 0.34238178952467 no 1123 0.331690631787507 1605 3840627
SGTC_780 0109-0199 192 µM 0.434407811867723 0.342701769615674 no 1124 0.331996162997754 1707 610414
SGTC_1194 1488-0194 225 µM 0.432997369304431 0.343238159232333 no 1125 0.332508340495249 1581 1391452
SGTC_2371 9071574 200 µM 0.432444133269518 0.343448640568613 no 1126 0.332709323945746 1573 45596039
SGTC_2957 9076800 11.52 µM 0.431009894776392 0.343994529550499 no 1127 0.333230587934802 1532 16459615
SGTC_2404 5161160 200 µM 0.42956896225512 0.344543293995566 no 1128 0.333754609410349 1631 2831543
SGTC_908 3448-7491 47.7 µM 0.428554944899072 0.3449296684699 no 1129 0.334123569932493 1548 1203031
SGTC_337 1315-0038 354 µM 0.424962396950578 0.346299848577508 no 1130 0.335432043485476 1582 1626437
SGTC_1011 4112-3381 17.4 µM 0.423364585777647 0.346909894089854 no 1131 0.336014639498205 1631 2877139
SGTC_1753 st043925 64 µM 0.423361827072551 0.346910947709339 no 1132 0.336015645722159 1658 670181
SGTC_1049 3226-0134 66 µM 0.423139672014766 0.346995798248846 no 1133 0.336096679531202 1590 5702385
SGTC_512 prima-1 270 µM 0.42310446778948 0.347009244955902 no 1134 0.336109521407743 1653 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_3060 1327-0027 12.5 µM 0.422849207150351 0.347106750805059 no 1135 0.33620264167923 1673 16000455 YPR107C YTH1
SGTC_2491 paeonol 100 µM 0.422397372010603 0.347279370067168 no 1136 0.336367497885302 1563 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2455 5377712 9.75 µM 0.422103317774584 0.347391727677781 no 1137 0.336474803182179 1522 2243908
SGTC_226 1,3-diallylurea 8.28947 mM 0.420940577061159 0.347836140153848 no 1138 0.336899237058712 1612 74537 YKL182W FAS1
SGTC_542 3381-0244 89.3 µM 0.419947697077158 0.348215795535312 no 1139 0.33726183136346 1701 1112843
SGTC_829 1635-0120 117 µM 0.416374966379297 0.349583185332581 no 1140 0.338567821897839 1703 285054
SGTC_3258 9138477 49.47 µM 0.416036151453402 0.349712961543008 no 1141 0.338691774833966 1641 4970355
SGTC_329 k048-0121 21.3 µM 0.415812493592465 0.349798638791224 no 1142 0.338773607984248 1585 6832902
SGTC_305 1682-2595 20.8 µM 0.415284857954418 0.350000791966644 no 1143 0.338966692321158 1631 226033
SGTC_1378 2093-0007 380 nM 0.414819504615463 0.350179118199061 no 1144 0.339137020031362 1620 3618014
SGTC_1797 st048695 56.8 µM 0.414225098225973 0.35040694639564 no 1145 0.339354631306218 1692 592262 YIL048W NEO1
SGTC_2922 7999257 32.47 µM 0.413286397301674 0.350766847791527 no 1146 0.339698397394776 1562 2988377
SGTC_215 1287-0124 461.5 µM 0.411969259825567 0.351272068957517 no 1147 0.340180977354395 1704 5560863
SGTC_2270 7924575 90.91 µM 0.409726569199405 0.35213291390077 no 1148 0.34100326879644 1760 1262135
SGTC_2314 7727897 200 µM 0.409646829175355 0.352163535673027 no 1149 0.341032519730721 1555 900724
SGTC_3201 9113999 49.47 µM 0.409137765943554 0.352359048774096 no 1150 0.341219281280349 1692 16649224
SGTC_2905 7799065 20.05 µM 0.408979542047546 0.352419824902344 no 1151 0.341277337280699 1699 1296806
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.407727157924078 0.352901016929833 no 1152 0.34173699838841 1649 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.406745332285366 0.353278419404539 no 1153 0.342097520931963 1686 1377
SGTC_247 mechlorethamine 29.705 µM 0.406549052585393 0.353353884384901 no 1154 0.34216961135298 1646 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1034 k072-0165 12.7 µM 0.405355745607779 0.353812807159148 no 1155 0.342608017802385 1750 5835461
SGTC_2763 lisinopril 49.32 µM 0.404814469154099 0.354021041707705 no 1156 0.342806946138086 1638 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1747 st037496 66.6 µM 0.404151320035901 0.354276221427153 no 1157 0.343050724174557 1615 723305
SGTC_842 0271-0008 11.1 µM 0.402652531300795 0.354853196139257 no 1158 0.343601929500752 1681 1221709
SGTC_2236 dapsone 200 µM 0.402609614488421 0.354869722335364 no 1159 0.343617717801745 1656 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1057 3448-5381 134 µM 0.402545620279612 0.354894365419353 no 1160 0.343641260593465 1720 5497911
SGTC_1142 3253-1408 9.78 µM 0.402510877834018 0.354907744399935 no 1161 0.343654042225289 1672 256655
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.402417245893221 0.354943802047766 no 1162 0.343688489999256 1604 6708630 An antioxidant.
SGTC_417 st075190 100 µM 0.398872898658398 0.356309682534104 no 1163 0.344993429651976 1733 222757
SGTC_2750 bromebric acid 70.15 µM 0.397637934863901 0.356786033377674 no 1164 0.345448546710468 1663 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2930 9013230 14.89 µM 0.395484821558346 0.357617067255845 no 1165 0.346242560607355 1736 2995857
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.394207080533352 0.358110554671483 no 1166 0.346714079287766 1617 5106787 A p450 inhibitor.
SGTC_290 2043-6722 48.1 µM 0.393146950879068 0.358520176573008 no 1167 0.34710547422735 1651 773758 YLR208W SEC13
SGTC_2002 4023503 131 µM 0.392491049782003 0.358773690778679 no 1168 0.347347711589076 1807 4736863 YCR052W RSC6
SGTC_875 0709-0210 25.7 µM 0.391114304037492 0.359306022990458 no 1169 0.347856374005912 1700 6251364
SGTC_2071 5230951 39.92 µM 0.390446731934376 0.359564244703074 no 1170 0.348103118693496 1660 1799272
SGTC_24 0417-1663 219 µM 0.389568723559858 0.35990396232024 no 1171 0.348427741709229 1633 4329390
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.388851249400344 0.360181648495072 no 1172 0.348693093424697 1622 2724 A muscle relaxant with antifungal properties.
SGTC_422 cantharidin 155 µM 0.388567412703781 0.360291523039811 no 1173 0.34879808845857 1567 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_195 4234-0266 16.654 µM 0.388514502929946 0.36031200594301 no 1174 0.348817661780463 1636 2303354
SGTC_1452 4194-0072 190 µM 0.388317114462573 0.36038842426328 no 1175 0.34889068677313 1783 1343545
SGTC_1600 coumarin 106 71.1 µM 0.38811366467036 0.360467195043244 no 1176 0.34896596004557 1677 100336 A hepatotoxic, DNA x-linker.
SGTC_1335 1486-0900 202 µM 0.385783717136319 0.361369715213899 no 1177 0.349828427710701 1632 X1335
SGTC_699 0375-0592 111 µM 0.385666204213184 0.361415255093084 no 1178 0.349871947593318 1725 762578
SGTC_2673 kobusone 100 µM 0.385055488020603 0.361651958044403 no 1179 0.350098152740261 1715 6710676 An epoxy ketone and protein crosslinker.
SGTC_1530 rhein 70.4 µM 0.384229379104013 0.361972227702836 no 1180 0.35040422253607 1651 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_3028 9087778 49.47 µM 0.384098594547582 0.362022939723955 no 1181 0.350452686564638 1579 17217395
SGTC_916 4466-0038 42 nM 0.384008457915447 0.362057891826395 no 1182 0.350486089359166 1732 5722064 YGL116W CDC20
SGTC_2147 5545932 89.7195 µM 0.383649305165695 0.362197171194387 no 1183 0.350619195510714 1661 797404
SGTC_264 promethazine 12.5 mM 0.382912450645634 0.362482980339511 no 1184 0.350892339696755 1638 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_254 nsc-64875 3.808 µM 0.38227465222343 0.36273042977238 no 1185 0.351128827070915 1769 56993
SGTC_1644 st010134 20.9 µM 0.381522606448 0.363022277908436 no 1186 0.351407749959551 1736 3818134
SGTC_1102 cgs 12066b 26.1 µM 0.380735893206155 0.363327664679465 no 1187 0.351699616167569 1680 6438352 A 5-HT1B full agonist.
SGTC_3005 9076496 71.4286 µM 0.37963636642827 0.363754625129373 no 1188 0.35210768090882 1701 21368410
SGTC_3125 9127534 49.47 µM 0.378830761332945 0.364067559453523 no 1189 0.352406771366571 1640 1639235
SGTC_2497 7-hydroxyflavone 100 µM 0.378795432814944 0.364081284762474 no 1190 0.35241988958913 1727 5281894
SGTC_1450 4112-4260 37.6 µM 0.376665425637333 0.364909124934152 no 1191 0.353211129952679 1768 1633175
SGTC_2732 terfenadine 20 µM 0.376231481914844 0.365077857178008 no 1192 0.353372406341662 1676 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2457 5731572 11.68 µM 0.37553381392612 0.365349189245351 no 1193 0.3536317517758 1780 2865357
SGTC_1300 1094-0077 113 µM 0.372862838727031 0.366388587877798 no 1194 0.354625265568927 1639 5532636
SGTC_420 mitomycin C 81.9 mM 0.371283165209886 0.367003773230854 no 1195 0.355213317750287 1642 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1766 st045414 44.774 µM 0.37026234352962 0.367401502123701 no 1196 0.355593514302827 1663 253960
SGTC_2887 9044784 58.44 µM 0.369139350427227 0.367839203042964 no 1197 0.356011929768493 1655 6465546
SGTC_301 4119-0100 24.5 µM 0.368879384999725 0.367940552383798 no 1198 0.356108814909026 1680 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_11 0438-0307 1.3 µM 0.368026428850529 0.36827314784335 no 1199 0.356426763849936 1773 4011476
SGTC_703 3875-0075 71.8 µM 0.366447407489696 0.368889120278334 no 1200 0.357015625014543 1726 2850814
SGTC_2891 9063876 19.48 µM 0.366438060966688 0.368892767339071 no 1201 0.357019111609947 1802 6472478
SGTC_2856 9022925 19.48 µM 0.363820847262342 0.369914480802446 no 1202 0.357995897052565 1696 4944862
SGTC_1411 3909-8223 150 µM 0.363191496943359 0.370160305240864 no 1203 0.358230919523713 1782 X1411
SGTC_2379 9035213 200 µM 0.362663777798316 0.370366473404319 no 1204 0.358428030606464 1833 646551
SGTC_2211 7117706 200 µM 0.361759214290151 0.37071995290525 no 1205 0.35876598649145 1759 822771
SGTC_1293 1000-1278 195 µM 0.361393300562537 0.370862973338258 no 1206 0.358902727728024 1734 678847
SGTC_2280 7785178 200 µM 0.360079106495249 0.371376784045843 no 1207 0.359393988445685 1700 2954328
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.359932476039745 0.371434126419023 no 1208 0.359448815013719 1668 75037 A free radical scavenger.
SGTC_1247 0448-0043 5.84 µM 0.356971831940495 0.372592546314749 no 1209 0.360556446590289 1691 3089013 YGL099W LSG1
SGTC_2808 7946468 45.46 µM 0.356188872707938 0.372899090350071 no 1210 0.360849562257456 1729 2970879
SGTC_3345 9148410 3.559 µM 0.356088723360574 0.372938306612499 no 1211 0.360887060969623 1782 4903596
SGTC_1061 3448-9325 110 µM 0.355262869220324 0.373261742934086 no 1212 0.361196334772566 1743 723482
SGTC_378 3970-0959 8.33 µM 0.354627291905178 0.373510720352345 no 1213 0.361434413686662 1729 6615653
SGTC_2047 4141938 200 µM 0.354347435611132 0.373620366406418 no 1214 0.361539261201424 1702 3807862
SGTC_1578 josamycin 24.2 µM 0.352449101877303 0.374364392073412 no 1215 0.362250741669506 1632 5282165 A P450 substrate.
SGTC_2931 9014674 55.67 µM 0.352424670014414 0.374373970861327 no 1216 0.362259901647021 1631 2996810
SGTC_1803 st050068 52.4 µM 0.351627890266897 0.374686399832522 no 1217 0.362558672971988 1718 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_3073 9114972 49.47 µM 0.350360972117752 0.37518334628413 no 1218 0.363033906080744 1823 41905075
SGTC_499 genistein 192 µM 0.350356070850143 0.375185269200818 no 1219 0.363035745003217 1759 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2021 4019055 173 µM 0.348013765833062 0.376104581004553 no 1220 0.363914922656808 1726 44827708 YER133W GLC7
SGTC_1487 3970-0795 2.82 µM 0.346530730360515 0.376687009320232 no 1221 0.364471946831373 1743 3765103
SGTC_3187 9109394 49.47 µM 0.346249682710946 0.376797416055048 no 1222 0.364577539886439 1648 17098090
SGTC_1457 k015-0032 57.3 µM 0.345918903115748 0.376927372391459 no 1223 0.364701831008431 1685 4302660
SGTC_2481 5478948 45.16 µM 0.345772664066204 0.376984831080131 no 1224 0.364756785170532 1697 77792
SGTC_1386 3228-0095 33.8 µM 0.345709539683692 0.377009634081564 no 1225 0.364780507104818 1790 870181
SGTC_1816 st051957 91.6 µM 0.344927506457959 0.377316954731846 no 1226 0.36507443551384 1724 674121
SGTC_1689 st020265 53.493 µM 0.344075400860934 0.37765190063821 no 1227 0.365394791000066 1809 5758320 YPR016C TIF6
SGTC_1152 3909-8331 15.9 µM 0.343806403294707 0.377757657399582 no 1228 0.365495942169422 1704 16001939
SGTC_1563 conessine 56.1 µM 0.343102114107153 0.378034593044499 no 1229 0.365760820365861 1807 441082 An anti-amoebic, histamine inhibitor.
SGTC_1868 st057644 42.7 µM 0.342602451614523 0.378231104838334 no 1230 0.365948778729715 1679 688665
SGTC_3329 9141233 27.5565 µM 0.342093589140102 0.378431267263529 no 1231 0.366140230929122 1798 4909101 YNL103W MET4
SGTC_2126 5251174 33.877 µM 0.341251759127042 0.378762474973244 no 1232 0.366457030543191 1897 790722
SGTC_20 0481-0013 4.944 µM 0.33952389798989 0.37944255952504 no 1233 0.367107548567257 1677 182045
SGTC_1927 st060202 13.8 µM 0.339405159704464 0.379489308532562 no 1234 0.367152266078357 1847 688887
SGTC_2446 5162541 200 µM 0.339287610757591 0.379535591015537 no 1235 0.367196537453003 1676 1549321
SGTC_660 4031-1742 102 µM 0.33703215411469 0.380423964312925 no 1236 0.368046330596995 1713 6738706
SGTC_872 0588-0139 234 µM 0.335886399971201 0.380875492930401 no 1237 0.368478266556564 1711 2047100
SGTC_709 3807-1509 243 µM 0.335421690624928 0.381058675866295 no 1238 0.368653503984967 1735 1886677 YPL242C IQG1
SGTC_1762 st045503 25.4615 µM 0.333790889192557 0.381701729203155 no 1239 0.369268679448108 1702 4645554
SGTC_3257 9139206 32.98 µM 0.333362975504247 0.381870517171272 no 1240 0.369430153778895 1802 4910041
SGTC_140 0062-0056 502.533 µM 0.331888447466149 0.382452307691919 no 1241 0.369986747015447 1645 3758964
SGTC_110 0850-0284 111.64 µM 0.331762761868845 0.382501910558886 no 1242 0.370034202441869 1726 3906265
SGTC_2493 resveratrol 26.09 µM 0.32941943565302 0.383427075971655 no 1243 0.370919339662456 1693 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2819 7996655 46.38 µM 0.329062635001644 0.383568002423222 no 1244 0.371054172916356 1815 6456960
SGTC_210 3551-0445 56.827 µM 0.328996568143222 0.383594098707366 no 1245 0.371079141002695 1772 2865180 YOR207C RET1
SGTC_1390 3413-2614 145 µM 0.328599319353786 0.383751022356844 no 1246 0.371229281300413 1729 3421432
SGTC_2733 amorolfine 100 µM 0.328445762306203 0.383811686512994 no 1247 0.371287323485745 1837 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2350 9023895 38.85 µM 0.327174302493356 0.384314097943669 no 1248 0.371768027956934 1799 2997209
SGTC_3276 9139060 49.47 µM 0.327127155588194 0.384332731567351 no 1249 0.37178585677313 1765 4870619
SGTC_1507 4075-3230 155 µM 0.325636508946771 0.384922009624629 no 1250 0.372349693166187 1840 659771
SGTC_263 alizarin 107.927 µM 0.3235597998453 0.385743411197083 no 1251 0.373135663526437 1767 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_655 k060-0012 42 µM 0.321975929493427 0.386370224851625 no 1252 0.373735464894025 1735 5994525
SGTC_1224 0823-0416 294 µM 0.318833677071523 0.387614641825099 no 1253 0.374926319675727 1818 3598164
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.316569612482932 0.388511989626488 no 1254 0.375785098213436 1841 17037758
SGTC_3140 9094243 49.47 µM 0.31506426537215 0.389108954335403 no 1255 0.3763564299418 1925 19291112
SGTC_2124 5246320 200 µM 0.314940324704738 0.389158116283596 no 1256 0.376403481839822 1782 579342
SGTC_1666 st014829 29 µM 0.314824626299433 0.389204010481254 no 1257 0.376447406365286 1733 3858230
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.314800743652938 0.389213484226084 no 1258 0.376456473534042 1730 16486 A toxic proline analog.
SGTC_1093 fluphenazine 7.97 µM 0.314385963891132 0.389378029155366 no 1259 0.376613957658507 1786 6602611 An atypical antipsychotic.
SGTC_2165 5727197 32.143 µM 0.313351879160649 0.38978834136353 no 1260 0.377006669679701 1808 1361712
SGTC_1631 benzylvanillin 81.9 µM 0.312454165240392 0.390144642938932 no 1261 0.377347695682554 1775 75506
SGTC_567 1080-0542 68.4 µM 0.312238644893823 0.39023019645695 no 1262 0.377429582387703 1868 5950415
SGTC_3122 9126309 49.47 µM 0.311451100343204 0.390542867372233 no 1263 0.377728855858218 1903 17591206
SGTC_2366 9070441 60.58 µM 0.311436826766254 0.390548534921147 no 1264 0.377734280613873 1695 6837235
SGTC_281 1672-3440 14.9 µM 0.310534373616373 0.390906915350082 no 1265 0.378077312083709 1839 6833000
SGTC_3088 9117578 49.47 µM 0.310339001365844 0.390984513409051 no 1266 0.378151587699555 1798 678341
SGTC_2515 chrysin 20.77 µM 0.309678787957444 0.391246769436995 no 1267 0.378402617540881 1844 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2423 st077119 87.2 µM 0.308668920407419 0.391648013927378 no 1268 0.378786694003802 1761 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2253 7938677 135.83 µM 0.307482240217178 0.392119657620425 no 1269 0.379238169483784 1889 2301972
SGTC_1811 st050069 61.5 µM 0.307033664527035 0.392297984471267 no 1270 0.379408874184052 1892 3877702
SGTC_639 0833-0042 114 µM 0.306538310113043 0.392494934023512 no 1271 0.379597407763392 1717 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_3183 9108214 49.47 µM 0.306026445815883 0.392698476720751 no 1272 0.379792255137396 1849 4974831
SGTC_839 0122-0028 230 µM 0.304736527761367 0.393211542336267 no 1273 0.380283413422813 1795 759448
SGTC_761 k216-0224 480 µM 0.302798561710151 0.393982717909175 no 1274 0.381021689792371 1953 1340404
SGTC_2533 agelasine 13.65 µM 0.302410914853972 0.394137024382284 no 1275 0.381169417594851 1943 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_3333 9141820 12.094 µM 0.301854232508387 0.394358646082761 no 1276 0.381381593185809 1747 1939433
SGTC_711 k292-0785 179 µM 0.301650695898921 0.394439684911078 no 1277 0.381459178648889 1742 4146315
SGTC_2796 7949634 45.45 µM 0.300943800695331 0.394721173231402 no 1278 0.381728674732981 1726 2971588
SGTC_2197 6588183 93.1375 µM 0.299251425855636 0.39539530632211 no 1279 0.382374106901766 1821 884136
SGTC_1016 4226-1401 38 µM 0.298856576180072 0.395552634118145 no 1280 0.382524740432375 1763 2901613
SGTC_1660 st012960 28.1 µM 0.297814173685331 0.395968060966934 no 1281 0.38292249806107 1791 24207266
SGTC_1788 fluconazole 20 µM 0.297355702420099 0.396150812170569 no 1282 0.383097479635536 1745 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2721 ifenprodil 61.44 µM 0.296173162313304 0.396622289680745 no 1283 0.383548921627557 1872 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2234 tolnaftate 200 µM 0.29531628872701 0.396964018796039 no 1284 0.383876137256078 1841 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2101 5377231 179.231 µM 0.294824058685341 0.397160360493805 no 1285 0.384064143359152 1877 2844213
SGTC_2646 retinol 96.75 µM 0.294460816337062 0.397305268041964 no 1286 0.38420290041668 1800 445354 A vitamin A analog and teratogen.
SGTC_2839 9003951 25.97 µM 0.294346314246882 0.397350949072746 no 1287 0.384246642813657 1896 2990634
SGTC_1650 st011916 45.8 µM 0.294309301617175 0.397365715698904 no 1288 0.384260782793506 1906 242528
SGTC_2860 9025725 38.96 µM 0.29429285147423 0.397372278725112 no 1289 0.384267067311023 1711 40546248
SGTC_936 3005-4620 401 µM 0.294288481493921 0.397374022197843 no 1290 0.384268736798154 1917 777207
SGTC_2861 9024595 19.48 µM 0.293975522433054 0.397498887492353 no 1291 0.384388303815862 1887 16482810
SGTC_1121 fusaric acid 630.51 nM 0.293907636905817 0.397525974039488 no 1292 0.384414241152615 1733 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1463 k081-0032 34.1 µM 0.293328781555598 0.397756959272109 no 1293 0.384635428097211 1718 977755
SGTC_132 0417-1715 25.805 µM 0.293173186172628 0.397819053845796 no 1294 0.384694889198267 1937 6769098
SGTC_1303 1160-0052 261 µM 0.292679813568684 0.398015964726251 no 1295 0.384883450501078 1857 3562476
SGTC_781 4335-2806 94.4 µM 0.289855639899424 0.399143624600469 no 1296 0.385963339798713 1916 845254
SGTC_1500 4488-1866 171 µM 0.289146654739803 0.399426846789404 no 1297 0.38623457614989 1890 2900003
SGTC_917 harmaline 728.087 nM 0.288513050576463 0.399680000918396 no 1298 0.386477021062718 1844 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_596 1155-0152 116 µM 0.287615199019221 0.400038806295777 no 1299 0.386820654574556 1771 280313
SGTC_1356 1502-0781 85.8 µM 0.287517965581922 0.400077668435663 no 1300 0.386857873927046 1801 567702
SGTC_3087 9117406 49.47 µM 0.287391491619617 0.400128218873022 no 1301 0.386906287626057 1800 42546093
SGTC_3283 9109332 35.8195 µM 0.28696008206676 0.400300661744144 no 1302 0.387071442616821 1775 17027281
SGTC_963 1269-2853 151 µM 0.28661067381246 0.400440341334599 no 1303 0.387205220328878 1731 3668223
SGTC_3321 9137793 26.8275 µM 0.286218605736382 0.400597089793509 no 1304 0.387355347129751 1805 4904192
SGTC_581 0958-0271 211 µM 0.285414413638515 0.400918655129329 no 1305 0.387663333051026 1756 4591145
SGTC_1497 4476-2978 41.3 µM 0.284538236429456 0.401269080951853 no 1306 0.387998967980018 1845 1528379
SGTC_1170 0310-0127 64.8 µM 0.283812218649734 0.401559510917771 no 1307 0.388277145138411 1840 774975
SGTC_855 0428-0020 25 µM 0.283320866897207 0.40175609795453 no 1308 0.388465441429192 1812 6812414
SGTC_1613 st002381 52.1 µM 0.282703876859017 0.402002987359883 no 1309 0.388701922065642 1923 551167
SGTC_1147 3809-1045 12.3 µM 0.282469879397812 0.402096631997124 no 1310 0.388791619669745 1791 325925
SGTC_1992 st073643 23.3 µM 0.282035479335999 0.402270491670288 no 1311 0.38895815276883 1786 3161292
SGTC_2162 5663267 200 µM 0.281253082950397 0.402583678454118 no 1312 0.389258146384054 1897 6456493
SGTC_1512 0259-0544 12.2 µM 0.280637853616555 0.402829993581796 no 1313 0.389494089648928 1853 18476
SGTC_862 0452-0056 10.2 µM 0.280636477572218 0.402830544542449 no 1314 0.389494617413922 1897 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_453 enantio-paf c16 10 µM 0.280159473004402 0.403021546191282 no 1315 0.389677578962328 1845 13871343 A lipid and platelet activating factor
SGTC_2266 7929956 200 µM 0.279257895566714 0.403382618019356 no 1316 0.390023457926459 1781 2967153
SGTC_3199 9111318 49.47 µM 0.27822518554029 0.403796308212017 no 1317 0.390419751277382 1879 8548020
SGTC_1847 st056231 15 µM 0.27796537916811 0.403900400226813 no 1318 0.390519467622083 1772 5393180
SGTC_586 0957-0265 8.15 µM 0.276405030828617 0.40452570027454 no 1319 0.391118496570031 1920 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_804 1595-0054 20.9 µM 0.275949179703145 0.404708425937059 no 1320 0.39129354992956 1813 761523 Stimulates phospholipase C.
SGTC_1075 aripiprazole 15.2 µM 0.273143446427326 0.405833546376405 no 1321 0.392371475306766 1805 60795 An atypical antipschotic. YIL048W NEO1
SGTC_3304 9125678 46.087 µM 0.27212477597525 0.406242234072726 no 1322 0.392763039835081 1784 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1153 4055-0057 267 µM 0.270720363734398 0.406805847733411 no 1323 0.393303056740437 1777 882706
SGTC_2925 9010536 32.5 µM 0.270144800977399 0.407036886351121 no 1324 0.393524428361638 1881 2994177
SGTC_2707 st078556 66.6 µM 0.269910911066724 0.407130782150649 no 1325 0.39361439640024 1970 17250899
SGTC_2125 5246583 200 µM 0.269241270790652 0.407399640727673 no 1326 0.393872011467101 1989 835267
SGTC_1861 st057647 17.4 µM 0.269145055841043 0.407438274331071 no 1327 0.393909029817032 1951 688668
SGTC_2412 st077135 33.4 µM 0.267647215234578 0.408039824607241 no 1328 0.39448544193731 1890 13258915
SGTC_3100 9120536 49.47 µM 0.267048844365742 0.408280198025203 no 1329 0.394715776923761 1950 16421196
SGTC_1382 3002-2117 298 µM 0.266245929196453 0.408602793786773 no 1330 0.395024906365208 1954 1497314
SGTC_598 3937-0236 20.2 µM 0.264629290007373 0.409252515789563 no 1331 0.39564752706323 1893 1379313
SGTC_2815 7968870 71.43 µM 0.264212456260747 0.40942008041835 no 1332 0.395808106654295 1798 2977326 YHR190W ERG9
SGTC_1330 1469-0054 61.8 µM 0.263657668040219 0.409643127573035 no 1333 0.396021858780011 1974 7102664
SGTC_2437 5741531 144.16 µM 0.26350024761357 0.409706422239239 no 1334 0.39608251636173 1953 2262990
SGTC_985 1493-0307 8.71 µM 0.263438979112542 0.409731057348956 no 1335 0.396106125154307 1960 3278274
SGTC_1789 tunicamycin 25 nM 0.26331248900955 0.409781918175921 no 1336 0.396154867206169 1970 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1414 3917-0015 5.4 µM 0.26326267311742 0.409801949230689 no 1337 0.396174063847704 1919 6618702
SGTC_365 0121-0052 13.6 µM 0.263255182451282 0.409804961260618 no 1338 0.396176950410834 1890 3101739
SGTC_1872 amphotericin b 148 nM 0.261995768002554 0.41031145291314 no 1339 0.396662352454639 1928 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_3203 9113543 49.47 µM 0.261793326785427 0.410392881544895 no 1340 0.39674039207467 1873 17018012
SGTC_1007 4101-0031 70 µM 0.261572083832865 0.410481877281687 no 1341 0.396825684357231 1962 1146276
SGTC_2134 5324836 1.464 µM 0.261568506096715 0.410483316476215 no 1342 0.396827063665607 1858 699272
SGTC_2245 6637752 200 µM 0.260994676901155 0.410714162903813 no 1343 0.397048306125187 1973 681890
SGTC_2467 5474540 200 µM 0.26042306187653 0.410944149342998 no 1344 0.397268727846778 1812 5413519
SGTC_1210 3013-0140 750 nM 0.259474392158049 0.411325909382848 no 1345 0.397634618844429 1971 905973
SGTC_1340 1486-1359 257 µM 0.25921273566874 0.411431218977485 no 1346 0.397735552604021 1863 4309068
SGTC_953 1188-0045 9.7 µM 0.259178643982444 0.411444940420683 no 1347 0.397748703946129 1884 6144426
SGTC_1268 0828-0275 2.46 µM 0.257082462453527 0.412288832619442 no 1348 0.39855755780264 1907 745337
SGTC_690 glyoxal 20.3 µM 0.254835821074946 0.413193748118515 no 1349 0.399424953601909 1875 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1873 rapamycin 2 nM 0.254808169667243 0.413204888599995 no 1350 0.399435632514171 1820 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1127 asiatic acid 681.4 nM 0.254526729018967 0.413318282256276 no 1351 0.399544328546598 1768 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2033 5192550 145 µM 0.254266234615179 0.413423243023773 no 1352 0.39964494180654 1812 182073
SGTC_2417 cerulenin 830 nM 0.251274584631951 0.41462910751134 no 1353 0.400800911723789 1853 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1875 nocodazole 6 µM 0.250015925400128 0.415136684999613 no 1354 0.401287516484858 1999 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1239 0337-0584 35.4 µM 0.249164345009471 0.41548018086527 no 1355 0.401616829175523 1994 914301 YML130C ERO1
SGTC_2949 9072542 2.23 µM 0.248938630146919 0.415571236689417 no 1356 0.401704126575139 1813 16457352
SGTC_1782 st039423 80.636 µM 0.248638040326286 0.415692504922301 no 1357 0.401820390202085 1805 2068169
SGTC_675 1309-0189 238 µM 0.248546510937871 0.415729432608939 no 1358 0.401855794120804 1846 4246530
SGTC_3235 9132602 49.47 µM 0.248282990246923 0.415835754632048 no 1359 0.401957729432022 1895 4912240
SGTC_1919 st067113 52.3 µM 0.247549844272795 0.416131587564356 no 1360 0.402241360687699 1852 1268243
SGTC_468 gf-109203x 121 µM 0.247204626539733 0.41627090340455 no 1361 0.402374932471824 1977 2396 A protein kinase C inhibitor.
SGTC_2770 toltrazuril 17.5 µM 0.244748489416153 0.417262403168857 no 1362 0.403325590225107 1986 68591 Kills coccidiodes.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.244604742241478 0.417320447764162 no 1363 0.403381245906713 1883 4213774
SGTC_349 k015-0014 24 µM 0.244456784989139 0.417380194255567 no 1364 0.403438533679713 1812 2196908
SGTC_463 ikarugamyin 104 µM 0.24378276712069 0.417652392952965 no 1365 0.40369953379214 1904 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_150 3970-0969 77.2 µM 0.243032508122489 0.417955427647501 no 1366 0.403990107212877 1901 6615640
SGTC_2769 toremifene 3.73 µM 0.242372872187038 0.418221899325738 no 1367 0.404245626328073 1895 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1309 pyrazolanthrone 13.4 µM 0.241277447758275 0.418664498402189 no 1368 0.404670044357948 1988 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1777 st045864 34.765 µM 0.240986307618723 0.418782149017046 no 1369 0.404782864388906 1882 4691462
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.239642913703707 0.4193251125154 no 1370 0.405303546811937 1862 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_3019 9081971 49.47 µM 0.238891319050846 0.419628953853041 no 1371 0.40559492854975 1995 16451803
SGTC_2487 5918373 44.05 µM 0.237042475463759 0.420376575074215 no 1372 0.406311919231896 2033 2876279
SGTC_2225 6654152 15.4 µM 0.235568802625145 0.420972693558125 no 1373 0.406883642053972 1962 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1892 st058411 7.36 µM 0.235500067718101 0.421000502093418 no 1374 0.406910313149381 1988 3934738
SGTC_2993 9054257 71.4286 µM 0.234097816323947 0.421567906052795 no 1375 0.407454520579972 1895 6470217 YGL055W OLE1
SGTC_1008 4106-0037 6 µM 0.232732608453775 0.422120477309726 no 1376 0.407984523250119 1894 2905394
SGTC_3216 9129716 49.47 µM 0.232106991991266 0.422373748418778 no 1377 0.40822745717037 1862 8056934
SGTC_3295 9122362 53.5725 µM 0.231355289071967 0.422678106119257 no 1378 0.408519398534854 1848 4730473
SGTC_2843 9000894 45.46 µM 0.23100485927904 0.422820007755222 no 1379 0.408655513482159 1911 2242070
SGTC_2409 alverine citrate 63.97 µM 0.230167602836658 0.423159083539427 no 1380 0.408980767620376 1965 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_387 norethindrone acetate 66.7 µM 0.229454632311364 0.423447870355127 no 1381 0.409257789073812 1859 541197
SGTC_561 1550-0330 72.9 µM 0.228830564497994 0.423700681124287 no 1382 0.409500304985627 1864 6812934
SGTC_1286 0929-0070 131 µM 0.228068603401962 0.424009395237058 no 1383 0.409796453876324 1966 1420408
SGTC_998 3996-0085 177 µM 0.226983141191434 0.424449258691687 no 1384 0.410218425717488 1986 715391
SGTC_1884 5633444 25 µM 0.224850215324706 0.425313861050489 no 1385 0.411047899976006 1928 5724239
SGTC_3263 9137018 49.47 µM 0.224620034862122 0.425407188505745 no 1386 0.411137438784672 1810 43844957
SGTC_677 0929-0063 136 µM 0.222770137091135 0.426157387223496 no 1387 0.411857205564921 1940 1539583
SGTC_1079 idarubicin 2.36 µM 0.222319128253926 0.426340327827812 no 1388 0.412032731241234 2030 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_92 0063-0024 660.874 µM 0.221954390829254 0.42648828615714 no 1389 0.412174694289718 2036 3594437
SGTC_2996 9066192 71.4286 µM 0.220985011631064 0.426881571955662 no 1390 0.412552051739168 1830 6472854
SGTC_1839 st053978 48 µM 0.220608823742937 0.427034214343365 no 1391 0.41269851498903 2032 3788398
SGTC_547 1120-0019 610 nM 0.220163428883576 0.427214952347979 no 1392 0.412871938674553 1891 3676939
SGTC_1091 telmisartan 47.6 µM 0.219783158525926 0.427369275394743 no 1393 0.413020018250315 1991 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1495 4469-0029 237 µM 0.218506575398454 0.427887425320243 no 1394 0.413517217833723 1893 793680
SGTC_324 1315-0088 19.6 µM 0.217327605137428 0.428366065844156 no 1395 0.413976522687404 1972 6787421
SGTC_1488 4013-0813 75.9 µM 0.216516137908631 0.428695568089005 no 1396 0.414292723626314 1903 2910057
SGTC_2779 methotrexate 400 µM 0.216153575947588 0.428842805123165 no 1397 0.414434019553178 2027 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_994 3910-0338 138 µM 0.215732745977826 0.429013717312442 no 1398 0.414598037296865 1995 3479481
SGTC_3340 9146634 11.102 µM 0.215599353945991 0.429067894760844 no 1399 0.414650029717131 1904 4907387
SGTC_918 glabranin 770.725 nM 0.215340672203784 0.429172962690764 no 1400 0.414750860763955 1949 124049 Also referred to as licorice root.
SGTC_2299 7976368 114.88 µM 0.213626024264756 0.429869522248614 no 1401 0.415419351709327 2009 2979718
SGTC_3287 9117173 37.0625 µM 0.212901613691381 0.430163872951329 no 1402 0.415701851847482 2052 2789709
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.212265355815724 0.430422436475496 no 1403 0.415950010812234 1888 6708784 An antioxidant flavonoid
SGTC_1451 4152-0210 104 µM 0.210938021322762 0.430961936769954 no 1404 0.416467817420265 2035 659563
SGTC_2990 9074105 71.4286 µM 0.210735327263001 0.431044333928796 no 1405 0.416546903206183 1988 6502001
SGTC_1993 st073995 70.8 µM 0.209952672803815 0.431362518917414 no 1406 0.41685230566323 1946 3098394
SGTC_2224 6650123 117.647 µM 0.209089198170035 0.431713612695402 no 1407 0.417189303478345 1945 2908370
SGTC_3303 9125618 40.5795 µM 0.208538862955399 0.431937410342422 no 1408 0.417404120666498 1986 22695467
SGTC_443 clozapine 122 µM 0.207915746592661 0.432190831315579 no 1409 0.417647376919185 2068 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3105 9121040 49.47 µM 0.205340102129127 0.433238638953833 no 1410 0.418653207282498 2075 41448907
SGTC_2858 9025781 8.96 µM 0.201330524721466 0.434870721942933 no 1411 0.420220067962888 2044 4894980 YPL153C RAD53
SGTC_412 gemfibrozil 100 µM 0.201292525169857 0.43488619486883 no 1412 0.420234923499946 2040 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1226 3909-7979 35.4 µM 0.201266414503544 0.434896826852218 no 1413 0.420245131264445 2036 6615510
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.200761496000136 0.435102433501294 no 1414 0.420442535816811 1982 4620898
SGTC_202 3594-0513 34.79 µM 0.200247376839748 0.435311804758757 no 1415 0.420643558048999 2052 708429
SGTC_2564 betulinic acid 100 µM 0.198873396701916 0.43587143693744 no 1416 0.421180890092647 2119 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_3339 9145883 14.936 µM 0.198149213496992 0.436166453819923 no 1417 0.421464160652421 2040 2030670
SGTC_3171 9103192 49.47 µM 0.197901930216725 0.436267199927893 no 1418 0.421560896976034 2088 13018434
SGTC_1072 oxiconazole 14.9 nM 0.196677195486221 0.436766232047335 no 1419 0.422040078444351 1999 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1351 1496-0003 46.5 µM 0.19639292444119 0.436882075943747 no 1420 0.422151316952214 2043 3891978
SGTC_2329 6138490 200 µM 0.195420029953756 0.437278583140567 no 1421 0.422532068627151 1924 720019
SGTC_1437 4092-1038 11.6 µM 0.194834248777678 0.437517351110057 no 1422 0.422761354700602 1964 3977136
SGTC_1195 1502-0147 41.1 µM 0.194615285561837 0.4376066076957 no 1423 0.42284706785856 1938 817940
SGTC_3271 9137798 49.47 µM 0.193872735678678 0.437909318987296 no 1424 0.42313776620751 2058 6498326
SGTC_1695 st026914 34.495 µM 0.192972715669552 0.438276273973008 no 1425 0.423490168096478 1933 3289191
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.19266359189181 0.438402321778269 no 1426 0.423611219322874 1932 6857784
SGTC_1969 st069479 40.1 µM 0.192293429042368 0.438553266995672 no 1427 0.423756182609581 2058 3895485
SGTC_2806 7952793 58.44 µM 0.191932647404472 0.438700395339023 no 1428 0.423897481953428 1983 2972490
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.190915064644275 0.439115415653051 no 1429 0.424296068689012 2063 140250 A respiratory chain inhibitor.
SGTC_8 0354-0001 70 µM 0.190473456385197 0.439295546083373 no 1430 0.424469070576692 1974 4993152
SGTC_2111 5486399 200 µM 0.190412978803717 0.439320215652148 no 1431 0.424492764056564 1977 689674
SGTC_2982 9019404 25.97 µM 0.190179491216006 0.439415460396444 no 1432 0.424584240734534 1766 22333232
SGTC_37 0566-0070 1.56 µM 0.189211267361148 0.439810457659147 no 1433 0.424963618547391 2052 1626686
SGTC_2043 5101342 149 µM 0.187676981706088 0.440436508438426 no 1434 0.425564937777585 1984 678451
SGTC_1276 0871-0068 94.2 µM 0.187224813865068 0.440621039740133 no 1435 0.425742185085925 2042 3414906
SGTC_131 0141-0277 33.849 µM 0.187185540865021 0.440637067800155 no 1436 0.42575758059485 2062 1547771
SGTC_338 4055-0136 114 µM 0.186204246214068 0.441037584362194 no 1437 0.426142297098408 1930 2900563
SGTC_1474 0330-0125 5.35 µM 0.185730027990202 0.441231158728063 no 1438 0.42632823954025 2063 X1474
SGTC_1911 st060208 74.3 µM 0.185083306753885 0.441495170894763 no 1439 0.42658184734038 2044 688783
SGTC_837 0091-0265 12.5 µM 0.182172991946592 0.44268357397567 no 1440 0.427723483811106 1954 759367
SGTC_1837 st055472 66.5 µM 0.180009051757805 0.443567536138258 no 1441 0.428572731002078 2030 676091
SGTC_3086 9117350 49.47 µM 0.17859839133704 0.444143937607082 no 1442 0.429126528853761 2073 2679265
SGTC_2229 7354935 190 µM 0.178407892117714 0.444221785430107 no 1443 0.429201325861154 2081 318112
SGTC_2019 4016004 108 µM 0.178397493973477 0.44422603471102 no 1444 0.429205408628616 1931 45595336
SGTC_1567 st069303 68.4 µM 0.178325608334093 0.44425541150092 no 1445 0.429233634290485 1967 5581319
SGTC_1961 st076550 68.7 µM 0.176184175363736 0.445130669380673 no 1446 0.430074626275501 2009 1579337
SGTC_1343 1487-0095 224 µM 0.176157523356703 0.445141564425307 no 1447 0.430085095163818 2103 4560101 YGL055W OLE1
SGTC_2183 6420625 130.508 µM 0.176093320367324 0.445167810064825 no 1448 0.430110314251554 2054 2897619
SGTC_797 k781-0471 270 µM 0.174655681337275 0.445755567485815 no 1449 0.430675096784776 2040 23738129
SGTC_2207 7258803 200 µM 0.173101873777245 0.44639095272727 no 1450 0.431285676062776 2075 3666799
SGTC_2000 st075254 36.4 µM 0.172565054767761 0.44661050161523 no 1451 0.431496661001314 1991 17234175
SGTC_903 1134-0042 114 µM 0.172275687332838 0.446728854251804 no 1452 0.431610398636802 1968 701009
SGTC_330 1488-0319 80.1 µM 0.170802778702282 0.447331354107906 no 1453 0.432189422047577 1998 6846614
SGTC_1701 st028638 40.4 µM 0.170645287004751 0.447395784008779 no 1454 0.432251343139336 2079 3490878
SGTC_2113 5491891 107.031 µM 0.169932990774299 0.447687201923505 no 1455 0.432531417776723 1960 789979
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.169494788484923 0.4478664953031 no 1456 0.432703735621892 2092 165506
SGTC_1342 1486-1464 234 µM 0.16887288468169 0.448120969655405 no 1457 0.432948313869653 1976 3253938
SGTC_2219 9098279 200 µM 0.167488565418855 0.448687490273893 no 1458 0.433492821960716 2102 902349
SGTC_755 1995-0008 37.3 µM 0.166560565523842 0.449067324820088 no 1459 0.433857912161625 2107 689533
SGTC_1024 4507-0395 26 µM 0.166060828050644 0.449271888984399 no 1460 0.434054540382034 2001 4201836
SGTC_2076 5212012 200 µM 0.164398065305067 0.44995262647193 no 1461 0.434708893258373 2093 604802
SGTC_3346 9158254 43.5805 µM 0.163210607746036 0.450438863597203 no 1462 0.435176307211728 2027 17639500
SGTC_273 hydroxyurea 18.1 mM 0.162166352953216 0.450866523921751 no 1463 0.435587427747068 2009 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2859 9028643 45.46 µM 0.16195178070627 0.450954406143671 no 1464 0.435671912948802 2081 17151580
SGTC_1950 st077106 7.18 µM 0.161881763252158 0.450983083669357 no 1465 0.435699482101767 1965 13831864
SGTC_944 3370-0224 231 µM 0.160751169684464 0.451446183897484 no 1466 0.4361446929422 1995 4580514
SGTC_2711 st079103 59.1 µM 0.160081528841592 0.451720505382154 no 1467 0.436408425686785 2098 54693780
SGTC_1963 st076565 50.3 µM 0.159732052378117 0.451863679204067 no 1468 0.436546075460406 2031 4914280
SGTC_541 4513-1321 94 µM 0.159417527292851 0.45199253946838 no 1469 0.436669965357107 1945 747515
SGTC_1373 2887-0003 58.5 µM 0.15810448872947 0.452530543075731 no 1470 0.437187231803652 2024 776948
SGTC_1284 0929-0043 16 µM 0.157495376460596 0.452780150016059 no 1471 0.437427225736356 2020 1239883
SGTC_256 clotrimazole 625 nM 0.156281994052919 0.453277435164683 no 1472 0.437905374303541 2126 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_562 3772-2733 112 µM 0.155928604258372 0.453422280067445 no 1473 0.438044649068886 2118 2876874 YIL048W NEO1
SGTC_2364 9055074 200 µM 0.155868450499874 0.453446936081048 no 1474 0.438068357084845 1992 6470630
SGTC_1953 st076800 12.1 µM 0.15523909591939 0.453704908677843 no 1475 0.438316413892074 1907 297591
SGTC_1637 st007924 17.4 µM 0.154688018252236 0.4539308115938 no 1476 0.438533638169944 2080 683336
SGTC_100 0086-0128 49.5915 µM 0.154450949596707 0.454027997585782 no 1477 0.438627091800816 1926 93297
SGTC_720 r052-1644 49.9 µM 0.154292850609925 0.454092811593447 no 1478 0.438689417101852 2042 1422863 YOR257W CDC31
SGTC_2904 7225135 42.03 µM 0.153271208525094 0.454511671747837 no 1479 0.439092202321808 2143 4446116
SGTC_1936 st074407 74.3 µM 0.15323305070932 0.454527316945891 no 1480 0.439107247370784 1956 809813
SGTC_2221 6807166 181.081 µM 0.153156391354072 0.454558748486366 no 1481 0.439137473259659 2108 674925
SGTC_866 0495-0101 262 µM 0.153028253639221 0.454611287598544 no 1482 0.439187997257054 1921 635694
SGTC_775 4577-0580 57.3 µM 0.15296415013047 0.454637571660444 no 1483 0.439213273290417 2084 2006902
SGTC_229 benomyl 22.8748 µM 0.152645776602041 0.454768115810006 no 1484 0.43933881174158 2043 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2854 9024559 71.43 µM 0.151761207883204 0.455130845154484 no 1485 0.439687639644697 2002 3163529
SGTC_3192 9110362 49.47 µM 0.151604861907961 0.455194960831462 no 1486 0.439749299244735 2100 16649480
SGTC_3131 9127911 49.47 µM 0.151464141222138 0.455252669755908 no 1487 0.439804797805458 2061 45595681
SGTC_340 k038-0059 454 µM 0.151431232133656 0.45526616576232 no 1488 0.439817776928297 2058 23733424
SGTC_2003 4023581 200 µM 0.150850253431796 0.455504433424644 no 1489 0.440046921652977 2013 16641307
SGTC_1236 0330-0013 258 µM 0.149152819321596 0.456200666776824 no 1490 0.440716524092135 2010 4617066
SGTC_162 k030-0015 37.8 µM 0.14907413373289 0.456232944374995 no 1491 0.440747568046219 2119 1809920 YMR134W ERG29
SGTC_629 3448-6466 76.7 µM 0.148561192321154 0.4564433650283 no 1492 0.440949948576631 2086 573744
SGTC_1483 3453-0561 55.9 µM 0.148478016695898 0.456477486782117 no 1493 0.44098276689247 2103 4546991
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.148147495839716 0.45661308197419 no 1494 0.441113183354977 2088 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1784 st039334 36.3 µM 0.147848018164166 0.456735946157454 no 1495 0.441231356357144 2161 3496984
SGTC_1710 st031758 61.5 µM 0.147390786677372 0.456923538642096 no 1496 0.441411788634486 2140 5394341
SGTC_146 3448-8650 53.125 µM 0.145745022836299 0.457598840177352 no 1497 0.442061338869672 2032 2891488 YIL048W NEO1
SGTC_1124 fisetin 1.16336 µM 0.145720224538781 0.457609016532525 no 1498 0.442071127460148 1980 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_3014 9081533 49.47 µM 0.145498195844893 0.457700130591298 no 1499 0.442158770050323 2149 21367265
SGTC_716 1683-5115 658 µM 0.144076873998767 0.458283451821547 no 1500 0.442719883024029 2168 723597
SGTC_652 0437-0092 114 µM 0.143432205665861 0.458548058274531 no 1501 0.442974424740501 2098 3091274
SGTC_2652 actinonin 100 µM 0.143225703310021 0.458632821804722 no 1502 0.443055965392321 2143 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_3239 9133757 49.47 µM 0.141041242974994 0.459529597058426 no 1503 0.44391868039875 2096 17036923
SGTC_1272 0839-0021 27 µM 0.140560302666443 0.459727062828865 no 1504 0.444108655343228 2089 5027250
SGTC_754 3474-0146 171 µM 0.140538995795274 0.459735811291733 no 1505 0.444117072010808 1950 24762078
SGTC_209 4077-0173 175.592 µM 0.139892422544983 0.460001299319753 no 1506 0.444372494174925 2091 15993494
SGTC_1642 st009582 77.7 µM 0.139735791035574 0.460065616129211 no 1507 0.444434373334643 2170 6739311
SGTC_421 streptovitacin 30 mM 0.139252612553013 0.460264027857268 no 1508 0.444625267326134 2021 91467 include heat shock
SGTC_2378 9074213 121.43 µM 0.137136693584803 0.461133021716489 no 1509 0.445461374581034 2172 657714
SGTC_1908 st060353 56.5 µM 0.136820081399706 0.461263068303657 no 1510 0.445586505126673 2180 4227716
SGTC_428 3448-4153 16.5 µM 0.136631084092904 0.461340699807742 no 1511 0.44566120267625 1930 3834874
SGTC_1744 st037937 38.9 µM 0.136592648684488 0.461356487507057 no 1512 0.445676393768116 2107 1016152
SGTC_787 4152-0075 138 µM 0.136060223768217 0.461575192217342 no 1513 0.44588683593883 2019 9566539
SGTC_2536 dehydroabietamide 32.04 µM 0.135861875939624 0.461656670725793 no 1514 0.445965237274295 2149 3983547
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.135633672767395 0.461750415381747 no 1515 0.446055442203579 2037 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_882 0843-0131 351 µM 0.135394671605152 0.461848598073096 no 1516 0.446149918392522 2177 5425421
SGTC_3113 9123498 49.47 µM 0.133914885646532 0.462456551956079 no 1517 0.446734939633684 2199 8897275
SGTC_1481 3346-2004 36 µM 0.133721306431246 0.462536088378592 no 1518 0.446811478191214 2181 2770522
SGTC_2068 5226020 147 µM 0.129153869697106 0.464413151340447 no 1519 0.448617948527037 2082 1810509
SGTC_3049 9092223 49.47 µM 0.128752342212338 0.464578204133936 no 1520 0.448776808476754 2092 8623917
SGTC_1255 0566-0045 221 µM 0.128627864468329 0.464629373475172 no 1521 0.448826058401113 2087 2788469
SGTC_1108 betulinic acid 729.144 nM 0.127651266734547 0.465030845894282 no 1522 0.449212478989958 2067 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_741 4582-0002 126 µM 0.127540829775648 0.465076247994812 no 1523 0.449256179769524 2063 2912688
SGTC_808 0711-0032 135 µM 0.127519835882523 0.465084878914545 no 1524 0.449264487289001 2187 4252555
SGTC_2014 4013930 200 µM 0.127407896829856 0.465130899097278 no 1525 0.449308783205668 2205 64556
SGTC_536 3852-0578 10.6 µM 0.126678914186216 0.465430608516073 no 1526 0.449597267704661 2162 2869208
SGTC_767 0929-0023 86 µM 0.126413776037843 0.465539620647921 no 1527 0.449702198965798 2183 1204563
SGTC_626 0214-0009 33 µM 0.126400484709441 0.465545085474911 no 1528 0.449707459243962 2147 3437874
SGTC_2614 arthonioic acid 13.39 µM 0.126322814903016 0.465577020114402 no 1529 0.449738198619495 2187 6710684
SGTC_1182 1222-0449 220 µM 0.125390290261316 0.46596045325755 no 1530 0.450107287348007 2122 658318
SGTC_1022 4477-0945 21.3 µM 0.125220278995933 0.46603036147936 no 1531 0.450174581642796 2040 4648966
SGTC_744 1594-0068 283 µM 0.124153033371092 0.466469234159918 no 1532 0.45059705418893 2102 668392
SGTC_3188 9110789 49.47 µM 0.122939360183781 0.46696837029422 no 1533 0.45107755855129 2174 849217
SGTC_880 0833-0487 87.2 µM 0.120244957406199 0.468076656924832 no 1534 0.452144552625032 2166 76075
SGTC_2963 9082507 9 µM 0.120045871415843 0.468158556736258 no 1535 0.452223405269326 2136 16459611
SGTC_3099 9120367 49.47 µM 0.119818256010243 0.468252194603291 no 1536 0.452313559961953 2193 24824940
SGTC_2150 5556613 200 µM 0.11953152413957 0.468370154675479 no 1537 0.4524271332064 2116 743190
SGTC_1750 st081859 2.357 µM 0.119348626304233 0.46844539939084 no 1538 0.452499580275927 2124 5291695
SGTC_2664 lyso-paf C-16 73.48 µM 0.118790823151755 0.468674888222714 no 1539 0.452720539633263 2192 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1173 0443-0020 122 µM 0.118729680882264 0.468700043731063 no 1540 0.452744760460757 2091 5331295
SGTC_964 1287-0107 19.4 µM 0.118265579743894 0.468890990989375 no 1541 0.452928614671908 2167 51516812 YPR165W RHO1
SGTC_3222 9128301 49.47 µM 0.118246068070104 0.4688990189238 no 1542 0.452936344465726 2134 4911358
SGTC_1988 st071872 53.4 µM 0.118228389167316 0.46890629278902 no 1543 0.452943348199768 2206 16414116
SGTC_456 gingerol 170 µM 0.117574893718327 0.469175176342603 no 1544 0.453202249425131 2142 442793 A herb.
SGTC_198 3454-2873 16.191 µM 0.11643496078233 0.469644240301975 no 1545 0.453653914557864 2106 710957
SGTC_2351 9026858 72.31 µM 0.115774628751519 0.469915975561695 no 1546 0.453915579299608 2146 1409300
SGTC_734 2023-0417 80 µM 0.115622654013697 0.469978517140282 no 1547 0.453975804006796 2158 3935732
SGTC_2387 9077560 195.08 µM 0.114957782991452 0.470252137638924 no 1548 0.454239292211149 2051 5303272
SGTC_1640 st009078 66.4 µM 0.114843751645838 0.470299067424108 no 1549 0.454284484828711 2194 690618
SGTC_2285 7945142 200 µM 0.114058287073603 0.470622337815199 no 1550 0.454595794230286 2117 2970608
SGTC_115 0527-0192 112.043 µM 0.11392494083651 0.470677220500332 no 1551 0.454648647176316 2069 4233931
SGTC_2385 9074692 200 µM 0.113240089515306 0.470959100570319 no 1552 0.454920106611714 2055 17046906
SGTC_171 k064-0041 9.68 µM 0.112993792739684 0.47106047818546 no 1553 0.455017738186855 2084 53325
SGTC_2580 diallyl disulphide 81.36 µM 0.112869676770362 0.471111565967957 no 1554 0.455066938551887 2111 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1155 4088-0394 48.2 µM 0.112831650565525 0.471127218154421 no 1555 0.455082012520958 2048 2326248
SGTC_2255 7941087 197.44 µM 0.112345677453871 0.471327256281105 no 1556 0.455274662825139 2215 935561
SGTC_1218 1348-1416 30.7 µM 0.11043597570984 0.472113404672411 no 1557 0.456031811559252 2171 6787668
SGTC_1209 2323-2347 50.3 µM 0.109518425056282 0.472491162682199 no 1558 0.456395654293854 2237 5412760
SGTC_1675 st018485 24.5 µM 0.106856566145404 0.473587195781069 no 1559 0.457451385512739 2085 3323024
SGTC_483 fpl-64176 144 µM 0.10630114607597 0.473815918135792 no 1560 0.457671711153475 2207 3423
SGTC_122 0236-0016 402.397 µM 0.105978862755169 0.47394863858431 no 1561 0.457799561402457 2214 6808838
SGTC_3126 9127922 49.47 µM 0.104666362217253 0.474489173027935 no 1562 0.458320277186989 2152 45595682
SGTC_970 1315-0089 19.5 µM 0.101363739500551 0.475849516181593 no 1563 0.459630859932561 2224 6811083 YLR033W RSC58
SGTC_1556 plumbagin 1.48 µM 0.100933131919784 0.476026903598598 no 1564 0.459801770965521 2226 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2834 9001755 58.44 µM 0.100794563759298 0.476083987321711 no 1565 0.459856771177872 2076 2989575
SGTC_62 0180-0423 3.232 µM 0.100376122568719 0.476256368863898 no 1566 0.460022862722447 2184 30102 YGL099W LSG1
SGTC_1729 st035615 45.989 µM 0.10002647791113 0.47640041231185 no 1567 0.460161652262612 2077 17385451
SGTC_730 1436-0052 41.2 µM 0.0989158818616295 0.476857966005398 no 1568 0.460602529423459 2255 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_801 0866-0028 10.1 µM 0.0976888228470074 0.477363536649602 no 1569 0.461089695589695 2210 6849771
SGTC_1611 st001856 99.4 µM 0.0975019698154022 0.477440526715657 no 1570 0.461163884999521 2065 647478
SGTC_1522 st012842 45.6 µM 0.0960834141551888 0.47802504913822 no 1571 0.461727161970871 2190 3491067 YOR116C RPO31
SGTC_1029 k015-0030 64.7 µM 0.0956020305452376 0.47822341628775 no 1572 0.461918326223835 2152 2208316
SGTC_233 rapamycin 362 pM 0.0955838574334471 0.478230905116471 no 1573 0.461925543196662 2237 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1266 0828-0227 32.9 µM 0.09440426645669 0.478717010714939 no 1574 0.462394013400664 2169 3913820
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.0942257345270625 0.478790585917881 no 1575 0.462464921259299 2155 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1926 methyl fluorone black 53.6 µM 0.0933367256809239 0.479156968103064 no 1576 0.462818028271153 2229 72721 Reacts with homocysteine.
SGTC_2739 tacrine 100.86 µM 0.0931985314853909 0.479213922884396 no 1577 0.462872920508962 2176 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2093 5331342 194.4 µM 0.0931646040004629 0.479227905681947 no 1578 0.462886396983186 2235 33839
SGTC_2222 6885208 172.143 µM 0.0927998059962427 0.479378254324973 no 1579 0.463031302569775 2217 609514
SGTC_824 1304-0008 100 µM 0.0924284587482778 0.479531305201102 no 1580 0.463178814694738 2163 768245
SGTC_3351 9150312 21.596 µM 0.0919263460988178 0.479738255870419 no 1581 0.463378279461984 2251 4904905
SGTC_1731 st035964 63 µM 0.0915584975254954 0.479889871749191 no 1582 0.463524413532738 2038 6739575
SGTC_174 3553-0389 74.3 µM 0.0910111602736773 0.480115472724852 no 1583 0.46374186162265 2200 738071
SGTC_603 3794-0023 45.9 µM 0.0909163765513471 0.480154541243227 no 1584 0.463779518739088 2245 3802260
SGTC_2787 5284540 71.43 µM 0.0902793020409356 0.480417139332149 no 1585 0.464032633778174 2145 736958
SGTC_2571 chrysanthemic acid 100 µM 0.0894516517964997 0.480758304210265 no 1586 0.464361487879554 2091 2743 An insecticide.
SGTC_2099 5377090 177.372 µM 0.0894089217421384 0.480775918307923 no 1587 0.464378466672652 2149 2243829
SGTC_157 1348-1695 65.819 µM 0.089196437362802 0.480863508751057 no 1588 0.46446289833329 2258 5380510
SGTC_1682 st012968 530 nM 0.0884166774832343 0.481184949738166 no 1589 0.464772753246159 2070 24207270
SGTC_1800 st050079 29.0735 µM 0.0883878346292286 0.481196839884937 no 1590 0.464784215005903 2225 3645560
SGTC_2348 9022543 33.42 µM 0.0881686919116232 0.481287179586139 no 1591 0.464871300309123 2177 3162678 YDL140C RPO21
SGTC_1930 st074634 34.3 µM 0.0878291771309106 0.481427143531503 no 1592 0.465006223685991 2256 684253 YOR116C RPO31
SGTC_962 1254-0300 21.5 µM 0.0871591663116469 0.481703360173586 no 1593 0.465272498175881 2195 7340576
SGTC_3261 9137475 49.47 µM 0.0870504021852376 0.481748199776862 no 1594 0.465315724488755 2253 17027690
SGTC_1131 3454-3128 32.3 µM 0.0868893640708406 0.481814590520766 no 1595 0.465379726893564 2168 710982
SGTC_2283 7944793 200 µM 0.0865273938873546 0.481963820818447 no 1596 0.465523590278315 2201 2970533
SGTC_116 0155-0182 31.788 µM 0.0860685547535725 0.48215299113526 no 1597 0.465705960255527 2095 771486
SGTC_2521 angolensin 13.4 µM 0.0858198203825743 0.48225554108838 no 1598 0.465804825109531 2171 821428 A flavenoid.
SGTC_2682 pyrogallin 40.03 µM 0.0855757589681672 0.48235616558337 no 1599 0.46590183464726 2264 822798 An ATP competetive kinase inhibitor.
SGTC_2431 5490079 200 µM 0.0853000836455417 0.482469825581707 no 1600 0.466011412518612 2193 5722345
SGTC_604 1000-0114 314 µM 0.0850563367339799 0.48257032279181 no 1601 0.466108301348719 2265 1572745
SGTC_355 1311-2252 105 µM 0.0840150296302321 0.482999667635482 no 1602 0.466522241050184 2151 5338538
SGTC_1810 st050138 53 µM 0.0834128096417736 0.483247980019646 no 1603 0.466761651693279 2272 3444541
SGTC_3018 9082602 49.47 µM 0.0828293788120533 0.483488551298495 no 1604 0.466993604236464 2168 17332089
SGTC_3166 9102297 49.47 µM 0.0816867280556958 0.483959728090988 no 1605 0.467447916281675 2175 25237072
SGTC_2936 9038235 15.59 µM 0.0814332535570195 0.484064252413644 no 1606 0.467548702202258 2258 4749415
SGTC_2897 9048598 12.99 µM 0.0812608380746013 0.484135351361831 no 1607 0.467617258820945 2223 6467404
SGTC_2402 5553605 200 µM 0.0809171460569593 0.484277081093438 no 1608 0.467753922048761 2221 6758546
SGTC_1924 st058459 75.1 µM 0.0806425009566513 0.484390339084413 no 1609 0.467863132688666 2285 688683
SGTC_308 4092-1169 104 µM 0.0793361989693132 0.484929048242284 no 1610 0.468382607208541 2214 2268590 YDL196W YDL196W
SGTC_294 k038-0071 157 µM 0.0792400423913771 0.484968703593951 no 1611 0.468420847742305 2188 24152826
SGTC_1685 st024049 53.0905 µM 0.0786366551913809 0.485217546230529 no 1612 0.468660815586929 2193 1941139
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.0780762849115196 0.485448653436831 no 1613 0.468883685748069 2279 688801
SGTC_1394 3474-0001 65.7 µM 0.077797783600921 0.485563514420267 no 1614 0.46899445476872 2202 5017666 YIL048W NEO1
SGTC_481 bay k-8644 50 µM 0.0777124577560145 0.485598705196626 no 1615 0.469028392110448 2137 2303 A calcium channel antagonist.
SGTC_111 0083-0039 52.457 µM 0.0773491893311913 0.485748528555844 no 1616 0.469172880328803 2281 759313
SGTC_1391 3442-0225 151 µM 0.0771841014687603 0.485816616664829 no 1617 0.469238544552065 2223 5227075
SGTC_98 0074-0023 107.663 µM 0.076919898707853 0.48592558414444 no 1618 0.469343633782259 2098 3563821
SGTC_72 0744-0168 198.391 µM 0.07512689410686 0.486665116230292 no 1619 0.470056874941445 2138 677577
SGTC_747 3448-8087 38.7 µM 0.0746275953391414 0.486871062322759 no 1620 0.470255508716932 2210 5168703
SGTC_1819 st053448 58.6 µM 0.0736950377910882 0.487255724284919 no 1621 0.470626523661506 2209 2857616
SGTC_1314 1222-0010 41.1 µM 0.0720591608897707 0.487930520309689 no 1622 0.471277413292842 2214 3526027
SGTC_707 0865-0008 204 µM 0.0720259734121134 0.487944210443505 no 1623 0.471290618867022 2224 723043
SGTC_572 0960-0087 17.7 µM 0.0719995926277154 0.487955092765105 no 1624 0.471301116023698 2250 6796365
SGTC_2525 harmine 47.85 µM 0.0712374965526367 0.488269468400436 no 1625 0.471604369637686 2232 5280953 A monoamine oxidase inhibitor
SGTC_505 gw-5074 63.9 µM 0.0707639420508239 0.488464820154523 no 1626 0.471792814963593 2250 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_448 monastrol 171 µM 0.0698704393908157 0.488833417354166 no 1627 0.47214839077937 2243 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_535 2293-4129 48.2 µM 0.0693106115388856 0.489064368360838 no 1628 0.472371189632918 2281 396118 YIL048W NEO1
SGTC_2309 7664088 163.95 µM 0.0680941453315184 0.489566221050554 no 1629 0.472855345444803 2301 704922
SGTC_663 1486-0733 13.9 µM 0.0679952867868691 0.48960700584352 no 1630 0.47289469310104 2221 722445 YPR165W RHO1
SGTC_32 0928-0142 34.1 µM 0.067922532097616 0.489637021375448 no 1631 0.472923651075459 2290 2244242
SGTC_1897 st060201 15 µM 0.0676546305366647 0.489747546822709 no 1632 0.473030283050591 2115 611878
SGTC_1420 4'-methoxyflavone 42 µM 0.0670846643783174 0.489982694625509 no 1633 0.473257151222062 2288 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_3307 9126885 69.2785 µM 0.0658674753719971 0.49048487515224 no 1634 0.473741667611091 2261 24824909
SGTC_2326 6164455 177.58 µM 0.0656428439548678 0.490577553904907 no 1635 0.473831089054008 2237 2888790
SGTC_556 4058-0063 51.5 µM 0.0655392515428382 0.490620294382726 no 1636 0.473872327643567 2216 6615692
SGTC_33 0986-0033 35.816 µM 0.0639863462606229 0.491261009481769 no 1637 0.474490549316842 2297 2848082
SGTC_2325 6158266 200 µM 0.0636039109717558 0.491418802451727 no 1638 0.474642808772537 2226 3623240
SGTC_178 4092-0806 87.505 µM 0.0622139859792154 0.491992297247467 no 1639 0.475196212432645 2298 2169044
SGTC_3337 9144342 33.5465 µM 0.0616396283601531 0.492229286955035 no 1640 0.475424909029475 2280 17682949
SGTC_1620 st003704 16.5 µM 0.0612970238490103 0.492370652705982 no 1641 0.47556133048581 2276 2834414
SGTC_2639 lactacystin 53 µM 0.0604817803083711 0.492707042976261 no 1642 0.475885963244782 2264 3870 A proteasome inhibitor.
SGTC_1891 st059073 26.2 µM 0.0596273918669645 0.493059590992551 no 1643 0.476226200811628 2316 688754
SGTC_1275 0867-0008 21.1 µM 0.059190461276968 0.493239884650699 no 1644 0.476400203560657 2245 3422836
SGTC_1347 1493-0251 600 nM 0.0589343167067969 0.493345579981276 no 1645 0.476502212382019 2296 3986378
SGTC_2969 9091408 28.7 µM 0.0585416353907085 0.493507616651345 no 1646 0.476658599548321 2098 4286311
SGTC_2746 daunorubicin 9.88 µM 0.0585299111327001 0.493512454585233 no 1647 0.476663268844167 2298 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_996 3970-0799 1.8 µM 0.0580360819608298 0.493716230631411 no 1648 0.476859943850866 2258 6615648 YGL040C HEM2
SGTC_1446 4239-0190 62 µM 0.0575930818691775 0.493899033718134 no 1649 0.477036380198138 2197 1340085
SGTC_286 k060-0067 22.9 µM 0.0575822276570732 0.493903512702917 no 1650 0.477040703228006 2280 5985051
SGTC_853 0419-0306 21 µM 0.0564610338048797 0.49436617677898 no 1651 0.477487268250786 2202 762713
SGTC_1742 st038235 28.8875 µM 0.0564201539428584 0.494383046126185 no 1652 0.477503551000816 2242 564103 YBR002C RER2
SGTC_1612 st002233 45.4 µM 0.0562860590368573 0.494438381352183 no 1653 0.477556962252675 2306 1035021
SGTC_2227 7312221 64.1025 µM 0.0562257487418573 0.494463268863501 no 1654 0.477580984537217 2279 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1039 k821-0043 94 µM 0.0550460326142603 0.494950092092773 no 1655 0.478050895319383 2287 15992768
SGTC_1990 st072050 59.8 µM 0.054571271397771 0.495146009852089 no 1656 0.478240013372319 2306 17233948
SGTC_3112 9123419 49.47 µM 0.0542865750253044 0.495263494898198 no 1657 0.47835342267954 2322 17015854
SGTC_732 3970-1727 52.7 µM 0.0541215934330202 0.495331577689424 no 1658 0.478419144193542 2296 1275699
SGTC_723 4182-0001 115 µM 0.0536579810038721 0.495522896895553 no 1659 0.478603830422316 2232 744821 YLR208W SEC13
SGTC_914 3820-6779 408 µM 0.0535822795282368 0.495554136765739 no 1660 0.478633987557785 2315 2893481
SGTC_758 0868-0029 16 µM 0.0535515610544463 0.495566813423822 no 1661 0.478646224886182 2316 762687
SGTC_544 k015-0020 52.4 µM 0.0530556431201139 0.495771465545822 no 1662 0.478843786652765 2243 3008304
SGTC_1250 0485-0349 40.2 µM 0.0524542581376744 0.49601964259721 no 1663 0.479083370921711 2271 6842794 YDL195W SEC31
SGTC_1355 1499-0035 1.68 µM 0.0515865367161152 0.496377732951631 no 1664 0.479429073600187 2321 1548538
SGTC_1938 st074717 56.4 µM 0.0507172287244602 0.496736480976537 no 1665 0.47977542388995 2322 17250979
SGTC_2918 7977171 22.06 µM 0.0499751556157494 0.497042723516018 no 1666 0.480071093261479 2335 2236483
SGTC_971 1315-0384 26.7 µM 0.049802741851305 0.497113876369407 no 1667 0.480139790857566 2261 6769120
SGTC_2349 9023730 187.07 µM 0.0496071981349079 0.497194574755437 no 1668 0.480217705207135 2293 4126287
SGTC_2179 6298986 200 µM 0.0476511634695985 0.498001810968964 no 1669 0.480997127879605 2330 738374
SGTC_2722 naftopidil 47.16 µM 0.0475730728921149 0.498034038371855 no 1670 0.481028246221361 2307 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3234 9132280 49.47 µM 0.0462245248142697 0.498590576018433 no 1671 0.481565647694439 2234 17612295
SGTC_3051 9093778 49.47 µM 0.0455458508754893 0.498870661759223 no 1672 0.481836114540844 2334 17217378
SGTC_2432 5630864 12.22 µM 0.0453800084450991 0.498939104288606 no 1673 0.48190220775952 2281 5714970
SGTC_783 0848-0141 92.7 µM 0.0442738589442007 0.499395608609287 no 1674 0.482343054388327 2325 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_736 0958-0254 92.6 µM 0.0438173119603464 0.499584024337454 no 1675 0.482525013694202 2283 6812352
SGTC_188 3229-0966 278.469 µM 0.0434773297066245 0.499724334173558 no 1676 0.482660517853936 2336 5722370
SGTC_488 nitrendipine 139 µM 0.0430446646860219 0.499902894005587 no 1677 0.482832964778631 2341 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_815 1582-0027 36.9 µM 0.0429271500267675 0.499951392032746 no 1678 0.482879803051147 2292 3128206
SGTC_2688 kanamycin b 96.69 µM 0.0426915879241847 0.499951392032746 no 1679 0.482973692660857 2286 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_520 3584-0023 682 µM 0.0423447062591244 0.499808234779371 no 1680 0.483111953392774 2164 1340790
SGTC_2346 9031566 143.75 µM 0.0423277225511076 0.499801225643205 no 1681 0.483118722842632 2309 4771086
SGTC_3075 9116269 49.47 µM 0.0422947286800784 0.499787609150773 no 1682 0.483131873715901 2282 17015205 YNL244C SUI1
SGTC_622 1348-1566 26.3 µM 0.0421642220349276 0.499733749369986 no 1683 0.483183891931018 2295 7340407
SGTC_2307 7538926 6.34 µM 0.0406839822801574 0.499122858534752 no 1684 0.483773915655832 2266 96582
SGTC_3144 9087057 49.47 µM 0.0404742960587212 0.499036321746767 no 1685 0.483857499509322 2348 17249618
SGTC_681 1642-0006 26.6 µM 0.0401452089571175 0.498900508716002 no 1686 0.483988679648451 2340 4446530
SGTC_1366 1683-0113 21.9 µM 0.0400944504528194 0.498879560879793 no 1687 0.484008913071483 2331 708623
SGTC_1513 0337-0559 19 µM 0.0393818400085649 0.498585469689068 no 1688 0.484292979125358 2270 775073
SGTC_1647 st011722 22.4 µM 0.0392115312041197 0.498515184103628 no 1689 0.484360870068253 2320 2854783
SGTC_1882 5615643 20 µM 0.036512654158497 0.497401378739399 no 1690 0.485436794439334 2345 2253075
SGTC_186 3455-3465 67.277 µM 0.0361153733265326 0.497237425561549 no 1691 0.48559518209142 2351 755278
SGTC_414 piperonyl butoxide 100 µM 0.0358772498744188 0.497139155004793 no 1692 0.485690118078357 2338 5794 A potent inhibitor of cytochrome P450.
SGTC_530 4358-1714 28 µM 0.0351523465523742 0.496839997605542 no 1693 0.485979130333207 2273 1564641
SGTC_2257 7960413 200 µM 0.0325978837345549 0.495785822042131 no 1694 0.486997628735126 2284 2974689 YIL048W NEO1
SGTC_726 3448-4391 34.2 µM 0.0325190088337568 0.495753272383263 no 1695 0.48702907859424 2314 1356692
SGTC_2875 9039966 71.43 µM 0.0314802497851425 0.495324605750397 no 1696 0.48744327136319 2312 6463691
SGTC_2272 7805186 180 µM 0.0313991432971218 0.495291135605613 no 1697 0.487475612182802 2354 2956062 YPR165W RHO1
SGTC_738 1315-0003 72.4 µM 0.0300949077739979 0.494752922566784 no 1698 0.487995680950428 2337 6251474
SGTC_1717 st033143 58.0435 µM 0.0297596142518922 0.494614559993056 no 1699 0.488129383823822 2359 674616
SGTC_2151 5563267 85.4165 µM 0.0296838599649939 0.494583299239326 no 1700 0.488159592066129 2311 5310824
SGTC_2008 4012253 172 µM 0.0290619027883275 0.49432664375047 no 1701 0.488407610062657 2337 603940
SGTC_941 3237-0776 460 µM 0.0283881542775908 0.49404861881614 no 1702 0.488676285956097 2342 760008
SGTC_3042 9091578 49.47 µM 0.0276744205903445 0.493754096999943 no 1703 0.488960912649728 2343 25236497
SGTC_50 0929-0078 56.389 µM 0.0265738472089119 0.493299952724798 no 1704 0.489399816397589 2293 1377751
SGTC_370 0180-0345 38.7 µM 0.025737441853135 0.492954821401923 no 1705 0.489733379730029 2317 3989527
SGTC_2246 7293507 91.5585 µM 0.0253280618572772 0.492785898206851 no 1706 0.48989664549109 2352 887656
SGTC_1472 k841-0093 193 µM 0.0252667533085812 0.49276060046211 no 1707 0.489921096238324 2346 X1472
SGTC_2305 7443522 69.23 µM 0.0249946286028616 0.492648314005212 no 1708 0.490029624012785 2345 5415886
SGTC_2591 skatole 100 µM 0.0249274136167644 0.492620579263891 no 1709 0.490056430560365 2330 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_613 3914-0030 117 µM 0.0247685940774989 0.492555046120895 no 1710 0.490119770832567 2348 1145395
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.0244185900660406 0.492410625919324 no 1711 0.49025936000906 2369 688664
SGTC_76 0433-0009 400.328 µM 0.0239432233214229 0.492214479589653 no 1712 0.490448948464572 2233 2841569
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.0237733198822951 0.492144374306833 no 1713 0.490516710841447 2337 5377381
SGTC_125 0133-0007 11.75 µM 0.0223176787580561 0.491543760184133 no 1714 0.491097273392338 2361 26541
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.0215608213052387 0.491231479660281 no 1715 0.491399143164964 2368 23665772 A membrane-active detergent.
SGTC_381 3461-2219 42.7 µM 0.0211058992411948 0.491043780705921 no 1716 0.491580589515107 2366 2883159
SGTC_2048 5246248 200 µM 0.020304537471828 0.49071314701726 no 1717 0.491900218077558 2379 677046
SGTC_1622 st003707 19.4 µM 0.0200660315400173 0.490614743125528 no 1718 0.491995348795383 2317 10140899
SGTC_2262 9014885 67.46 µM 0.0181232006217619 0.489813182677202 no 1719 0.492770284785091 2341 6457424
SGTC_1004 4084-0029 199 µM 0.01768692854982 0.489633193946034 no 1720 0.492944304262163 2369 716894 YLR208W SEC13
SGTC_949 1165-0505 146 µM 0.0164126163799018 0.489107474990502 no 1721 0.4934526073449 2360 6244267
SGTC_1626 st003712 1.76 µM 0.0164059530154862 0.489104726060766 no 1722 0.493455265284827 2356 24207035
SGTC_3150 9097574 49.47 µM 0.01579555904777 0.488852914020427 no 1723 0.493698745681185 2373 17217476
SGTC_2924 9010168 62.78 µM 0.0154675145946704 0.488717584330375 no 1724 0.493829600494959 2362 2993929
SGTC_2795 7780010 54.55 µM 0.0151362985196293 0.488580947554417 no 1725 0.493961721121819 2369 953673
SGTC_2760 etidronate 98.04 µM 0.0133157151904648 0.487829925526117 no 1726 0.494687955195451 2388 3305 A chelator and antioxidant.
SGTC_2582 agaric acid 100 µM 0.0122804706582516 0.487402888374262 no 1727 0.495100924169742 2377 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_522 1273-0010 11.6 µM 0.0113802225355898 0.487031548805976 no 1728 0.495460046064888 2359 5705015
SGTC_168 3970-0862 530.542 µM 0.011372162918267 0.487028224378567 no 1729 0.495463261178949 2361 3135186
SGTC_2499 avocadenofuran 51.48 µM 0.0102752158991265 0.486575764661722 no 1730 0.495900854069059 2389 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_3164 9100705 49.47 µM 0.00954446441059337 0.486274359830278 no 1731 0.49619236741344 2391 17174235
SGTC_1893 st059353 36.1 µM 0.0093163724245233 0.486180282896718 no 1732 0.496283358904153 2367 3112488
SGTC_1756 st041558 35.5 µM 0.00892156641635079 0.48601744629762 no 1733 0.496440857163779 2395 3955792
SGTC_2537 larixol 68.93 µM 0.00876659363302908 0.485953528855903 no 1734 0.496502679941429 2384 6708759
SGTC_2167 5876490 200 µM 0.00647073453972672 0.485006660971317 no 1735 0.497418568421126 2383 686534
SGTC_2310 7668677 200 µM 0.00609466539975983 0.484851568867229 no 1736 0.497568595339545 2393 2197143
SGTC_828 2074-0507 139 µM 0.00571318919008941 0.484694249211845 no 1737 0.497720779675308 2394 X828
SGTC_676 falcarinol 140 µM 0.00527122218877614 0.484511986314399 no 1738 0.497897096337982 2399 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_135 0933-0004 26.348 µM 0.00506775357875115 0.484428078921889 no 1739 0.497978267484516 2387 21230617 YGL099W LSG1
SGTC_662 k832-1615 104 µM 0.00448340696022053 0.484187107017687 no 1740 0.498211385395463 2393 5878478
SGTC_2917 7979103 53.79 µM 0.0044723435577087 0.484182544765256 no 1741 0.49821579901024 2386 2980565
SGTC_1755 st041960 45.185 µM 0.00390881268692991 0.48395016240066 no 1742 0.498440613323946 2388 2257073
SGTC_1723 st034307 2.5525 µM 0.00225336922269997 0.483267541531382 no 1743 0.499101036504484 2399 867466
SGTC_1419 3993-2473 62.6 µM 0.00132889099478694 0.482886354841721 no 1744 0.499469849352171 2401 704026
SGTC_52 0329-0193 875 nM -0.000340381636166852 0.482198109689077 no 1745 0.499864207376483 2406 3739292
SGTC_2323 6148992 148.28 µM -0.000860950800066221 0.481983488515977 no 1746 0.49965653036694 2413 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1550 gossypolone 36.6 µM -0.000959650962055522 0.481942796826033 no 1747 0.49961715471557 2409 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3047 9092122 49.47 µM -0.0011548481382095 0.481862322305028 no 1748 0.499539282352633 2405 17173831
SGTC_2873 9040596 71.43 µM -0.00176274037705866 0.481611709511162 no 1749 0.499296768698407 2419 6463863
SGTC_2985 9022375 71.43 µM -0.00266542348112148 0.48123957814904 no 1750 0.498936651137297 2433 4939335
SGTC_1085 doxorubicin 7.67 µM -0.00326009902254054 0.480994431902505 no 1751 0.498699410965444 2412 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_147 4466-0538 29.23 µM -0.00340577229741498 0.480934381329614 no 1752 0.498641296059807 2421 6742687 YHR072W ERG7
SGTC_2452 5863136 48.41 µM -0.00382801991371647 0.480760321575164 no 1753 0.498472844735956 2412 2184096
SGTC_151 3013-0144 2.285 µM -0.00401923320111289 0.480681500457168 no 1754 0.498396562258336 2412 906558 YHR107C CDC12
SGTC_2192 5915882 198.485 µM -0.00530721872946725 0.480150592439983 no 1755 0.497882735996826 2410 2876149
SGTC_2088 5278280 127.392 µM -0.00542224745639156 0.480103179263371 no 1756 0.497836846834579 2419 791502
SGTC_1772 st048439 82.2 µM -0.00626133051344151 0.479757329928574 no 1757 0.497502106847973 2422 2927068 YDL195W SEC31
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.00649704458666083 0.479660177133475 no 1758 0.497408072451637 2419 6710655
SGTC_689 0833-0039 98 µM -0.00682527633652428 0.479524893920383 no 1759 0.497277129834498 2417 5374726
SGTC_27 0485-0001 32.618 µM -0.0077912187908289 0.479126787130476 no 1760 0.496891784854889 2419 2054479
SGTC_1776 st049249 45.9 µM -0.0085926772779894 0.478796487108011 no 1761 0.496572059915164 2420 1822314
SGTC_2989 9073649 71.4286 µM -0.00913143812620759 0.47857445917413 no 1762 0.496357133876273 2428 21367202
SGTC_2049 5262831 67.185 µM -0.00953802203844973 0.478406906879703 no 1763 0.49619493743109 2425 763417
SGTC_1970 st070122 35.8 µM -0.00961372616634193 0.478375709803392 no 1764 0.496164737238351 2440 102928
SGTC_934 2950-0684 338 µM -0.00966260954317521 0.478355565418253 no 1765 0.4961452364983 2415 1121253
SGTC_331 k048-0133 24.5 µM -0.010310792129986 0.478088460647661 no 1766 0.495886661958211 2423 6813582
SGTC_978 1416-0512 87.4 µM -0.0110141871920799 0.477798614915119 no 1767 0.495606063884767 2427 6814003
SGTC_323 4013-0906 34.3 µM -0.011223591544839 0.477712328600887 no 1768 0.495522528798772 2432 2910086
SGTC_769 0302-0231 76 µM -0.0135585909986041 0.476750249833315 no 1769 0.494591070513938 2431 571869 YER009W NTF2
SGTC_2693 st077581 40.7 µM -0.013902982094189 0.476608363332949 no 1770 0.494453691296565 2424 25238761
SGTC_2303 7774051 200 µM -0.0147466476923362 0.476260792119379 no 1771 0.494117151959686 2458 2953184
SGTC_1365 1672-3266 55.4 µM -0.0153966698854682 0.475993009929373 no 1772 0.493857860079593 2430 6415873
SGTC_1167 k781-0610 148 µM -0.0163646819119952 0.47559424924544 no 1773 0.493471727862893 2444 4525169
SGTC_2601 securinine 100 µM -0.0164017288678291 0.475578988689373 no 1774 0.49345695024921 2442 442872 A GABA receptor antagonist.
SGTC_687 k029-0044 34.9 µM -0.0166697679643863 0.475468577834271 no 1775 0.493350032739392 2437 5829338
SGTC_906 1165-0455 526 µM -0.0170475565968428 0.475312962072879 no 1776 0.49319933829804 2430 3252859
SGTC_3250 9135583 49.47 µM -0.0177732557298615 0.475014048303255 no 1777 0.492909870112826 2452 7699353
SGTC_1941 st076221 61.8 µM -0.0178143206180684 0.474997134191018 no 1778 0.492893490185984 2430 2828568
SGTC_2318 6029776 164 µM -0.0184982668148972 0.474715431982139 no 1779 0.49262068010563 2449 818325
SGTC_2680 butyl paraben 22.24 µM -0.0205287050060764 0.473879214710665 no 1780 0.491810806807409 2442 7184 An antifungal and steroid mimetic.
SGTC_1383 3049-0032 20.7 µM -0.0214648656927369 0.473493704090694 no 1781 0.491437415058631 2445 712864
SGTC_1805 st050013 60.3 µM -0.0216847540829046 0.473403157720697 no 1782 0.491349712696891 2455 4037144
SGTC_2846 9008642 19.48 µM -0.0233353423149588 0.472723517223825 no 1783 0.490691390146199 2483 2992898
SGTC_6 0844-0013 19.835 µM -0.0234091643425293 0.472693122361648 no 1784 0.490661947460995 2449 1584900
SGTC_356 1634-0012 32.5 µM -0.0236022062570794 0.472613641655583 no 1785 0.490584956151961 2448 735457
SGTC_2050 5263056 171 µM -0.0240677053964556 0.472421987250494 no 1786 0.490399301608588 2456 763468 YGL055W OLE1
SGTC_2731 amoxapine 43.43 µM -0.0245148895648617 0.472237879462262 no 1787 0.490220953564593 2456 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_509 pifithrin 175 µM -0.0245498084484412 0.472223503445721 no 1788 0.490207027136894 2445 4817 A p53 inhibitor.
SGTC_1040 k898-0338 155 µM -0.0261746501574906 0.471554600531239 no 1789 0.489559017598669 2450 20969351
SGTC_3173 9105693 49.47 µM -0.027032528401537 0.471201467752522 no 1790 0.489216894796465 2477 17096658
SGTC_1184 1269-1718 139 µM -0.0272191866184372 0.471124635672271 no 1791 0.489142456333268 2470 5403821
SGTC_2361 9034121 116 µM -0.0273469830483525 0.471072032845233 no 1792 0.489091491905767 2475 6496917
SGTC_2544 sphondin 68.51 µM -0.0292438518124534 0.470291314537815 no 1793 0.488335053743162 2453 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2636 apigenin dimethyl ether 100 µM -0.0293760281967917 0.470236917249688 no 1794 0.488282345639923 2501 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.0295509716780741 0.47016491998561 no 1795 0.488212583575369 2458 6312947
SGTC_2641 levomentholum 100 µM -0.0298991816845652 0.470021618506762 no 1796 0.488073729240044 2447 16666
SGTC_823 0417-1665 178 µM -0.0311036407570054 0.469525968478202 no 1797 0.487593443085794 2496 3429856
SGTC_384 k007-0144 5.16 µM -0.0313334081667682 0.469431421644195 no 1798 0.487501823808366 2499 6824886
SGTC_3352 9151559 45.5865 µM -0.0317151469642332 0.469274344021279 no 1799 0.487349607716365 2486 17159339
SGTC_2526 patulin 37.61 µM -0.0323079630273556 0.469030421955747 no 1800 0.487113229471856 2503 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2742 clothiapine 36.27 µM -0.0330968829444029 0.468705828390378 no 1801 0.486798664219892 2463 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2235 salicylic acid 500 µM -0.0333335622164221 0.46860845301074 no 1802 0.486704294922481 2453 338 A COX inhibitor and kinase inhibitor.
SGTC_3221 9128209 49.47 µM -0.0334076254840646 0.468577982038346 no 1803 0.486674764400722 2490 16460723
SGTC_1104 tacrolimus 29.8 µM -0.0334938081793328 0.468542525145213 no 1804 0.486640401710205 2467 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1834 st055981 52.8 µM -0.0340568354005954 0.468310893194991 no 1805 0.486415914430556 2514 471719 YDL150W RPC53
SGTC_646 4092-0839 27.3 µM -0.0353690438150573 0.467771086477138 no 1806 0.485892734358718 2490 877796
SGTC_1564 D-Arginine 115 µM -0.0362799174551196 0.467396412713467 no 1807 0.485529581472936 2487 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_901 1112-0062 60.1 µM -0.0363019941180936 0.467387332177266 no 1808 0.48552077995652 2459 1908457
SGTC_2999 9069765 71.4286 µM -0.0375626065615589 0.466868847468625 no 1809 0.48501821125433 2496 2097066
SGTC_988 1497-1057 103 µM -0.0376887167113854 0.46681698196175 no 1810 0.484967936183176 2459 3533044
SGTC_1870 st057514 26.5 µM -0.0379989777083958 0.466689382865144 no 1811 0.484844248555761 2467 5393161
SGTC_2653 dihydrofissinolide 100 µM -0.0380415572668444 0.466671871703744 no 1812 0.484827274042726 2501 6857746
SGTC_2983 9022671 12.99 µM -0.0392989675575555 0.466154781558169 no 1813 0.484326014875867 2517 6405161
SGTC_363 0455-0021 3.06 µM -0.0396291077107439 0.466019026061705 no 1814 0.484194410531789 2490 4597466
SGTC_3006 9075424 71.4286 µM -0.0397783664411754 0.465957651325293 no 1815 0.484134911828526 2487 7465181
SGTC_595 3909-8003 73.7 µM -0.0401685882458856 0.46579719713391 no 1816 0.483979360178885 2506 699517
SGTC_2456 5770359 74.46 µM -0.0402087873293628 0.465780668102817 no 1817 0.483963336010643 2485 3118787
SGTC_2546 rhodinyl acetate 100 µM -0.0412898192558117 0.465336192380108 no 1818 0.48353242460367 2485 6708682
SGTC_1775 st081588 35.1725 µM -0.0422661853646669 0.464934788071811 no 1819 0.483143250677756 2482 1426443 YGL099W LSG1
SGTC_1686 st019653 115.5 µM -0.0426271241314071 0.464786407688408 no 1820 0.482999386603523 2473 97252
SGTC_1754 st042065 16.137 µM -0.0427560136883967 0.464733422928142 no 1821 0.482948013946244 2521 1126236 YIL048W NEO1
SGTC_818 4072-2707 53.5 µM -0.043273010534705 0.464520898784617 no 1822 0.482741952768084 2490 882871
SGTC_148 3253-0744 288.01 µM -0.0432946997457189 0.464511983127052 no 1823 0.48273330812641 2474 6893655
SGTC_3181 9108277 49.47 µM -0.0436461066745241 0.46436753481501 no 1824 0.482593249440905 2477 17097298
SGTC_21 0849-0113 22.993 µM -0.0444810633849647 0.464024338804044 no 1825 0.482260473132487 2473 1560156
SGTC_1931 st074438 57.1 µM -0.0466943759161755 0.463114721198871 no 1826 0.48137840641353 2472 2787313
SGTC_2281 7943571 200 µM -0.0485914707461375 0.462335214658184 no 1827 0.480622433647902 2504 1244024
SGTC_570 0987-0065 62.6 µM -0.0497187610789044 0.461872085154402 no 1828 0.480173252884547 2494 3104428
SGTC_1748 st037455 53.6035 µM -0.0502306463679588 0.461661802162435 no 1829 0.479969295050727 2549 580690
SGTC_1610 st001799 48.1 µM -0.0506727202969061 0.461480206369729 no 1830 0.479793157381524 2499 621897
SGTC_2793 7325131 81.82 µM -0.0513648683520962 0.461195900896215 no 1831 0.479517389397795 2547 4176441
SGTC_495 decylubiquinone 155 µM -0.0524981822410475 0.460730425834552 no 1832 0.479065871850409 2550 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_3277 9138724 49.47 µM -0.053097022070091 0.460484491823313 no 1833 0.478827302075789 2526 15943418
SGTC_1087 pterostilbene 9.05 µM -0.0532220955579441 0.460433128032405 no 1834 0.47877747542665 2532 5281727 Similar to reservatol, lowers cholesterol.
SGTC_805 3852-0218 479 µM -0.0535365352883399 0.460304000334293 no 1835 0.478652210712846 2511 6615355
SGTC_484 loperamide 105 µM -0.0537956633455313 0.460197590052372 no 1836 0.478548982333623 2494 3955 An opioid-receptor agonist.
SGTC_2830 7992007 71.43 µM -0.0539639069560761 0.46012850276458 no 1837 0.478481960198363 2494 1952075
SGTC_1645 Cervolide 78 µM -0.0548888891987684 0.459748691089267 no 1838 0.478113491835141 2553 23173 A fragrance.
SGTC_1773 st048542 73.5835 µM -0.0574053234416098 0.458715592073943 no 1839 0.477111161252053 2506 3237138
SGTC_2393 9031399 185.94 µM -0.0576999376850404 0.458594658992258 no 1840 0.476993821667638 2555 1526623 YDL150W RPC53
SGTC_1387 3342-1166 1.8 µM -0.0579360554992177 0.458497740256342 no 1841 0.4768997816043 2578 3418228
SGTC_1923 st058458 19.1 µM -0.0591997951122623 0.457979058045285 no 1842 0.476396486417381 2529 3534982
SGTC_2549 cedrol 20.94 µM -0.0593242846381312 0.457927967118394 no 1843 0.476346909415509 2529 6708665 A sedative which affects the nervous system.
SGTC_553 k007-0256 45.7 µM -0.0593348566594609 0.45792362835672 no 1844 0.476342699205701 2547 6287000
SGTC_268 camptothecin 39.6153 µM -0.0596015905299632 0.457814162332788 no 1845 0.476236475781573 2500 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1128 3448-9350 235 µM -0.0599301457630675 0.457679329581644 no 1846 0.476105635095807 2619 619386
SGTC_2397 5161689 200 µM -0.0605709001993651 0.457416390305121 no 1847 0.475850474617014 2563 2259942
SGTC_246 cycloheximide 667 µM -0.0606455985332428 0.457385738390962 no 1848 0.475820728976786 2508 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2020 4017018 200 µM -0.0611845445694775 0.457164593356036 no 1849 0.47560611915879 2573 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_993 3909-8757 62.7 µM -0.062287033905168 0.456712251714483 no 1850 0.475167126936106 2563 4288324 YLR208W SEC13
SGTC_2290 7904846 200 µM -0.0624301035158052 0.456653555615203 no 1851 0.475110161285235 2560 2962154
SGTC_1679 SEC14.276 6.7 µM -0.0631169656142518 0.456371775030156 no 1852 0.474836682314103 2564 1005053 YMR079W SEC14
SGTC_13 0199-0087 65 µM -0.0636907635237937 0.456136395085969 no 1853 0.474608229727929 2520 4589825
SGTC_1485 3909-9022 254 µM -0.0664474604410616 0.455005775438003 no 1854 0.473510792849064 2516 714516
SGTC_886 0866-0150 153 µM -0.0674536045179795 0.454593210177228 no 1855 0.47311029804375 2547 271463
SGTC_3071 9117417 49.47 µM -0.0675719622909551 0.454544681267948 no 1856 0.473063187610467 2576 45595590 YGL055W OLE1
SGTC_1338 1486-1223 76 µM -0.0676701483581933 0.454504423651625 no 1857 0.473024106490439 2595 3444526
SGTC_1814 st052110 31.539 µM -0.0687567056817506 0.45405895173736 no 1858 0.472591640174916 2542 674163
SGTC_1561 5-methoxyflavone 52.9 µM -0.0695015548214199 0.453753608312047 no 1859 0.472295197539799 2517 94525
SGTC_2315 7733312 200 µM -0.0696785878992904 0.453681039393165 no 1860 0.472224742366193 2560 726316
SGTC_1736 st036774 51 µM -0.0703320203102025 0.453413199559647 no 1861 0.47196469853997 2549 1272247
SGTC_3215 9129942 49.47 µM -0.070769984229436 0.453233691417896 no 1862 0.471790410511327 2554 17682944
SGTC_1516 st013856 110 µM -0.0713286598805853 0.453004721068221 no 1863 0.471568093014726 2672 5281404 A mutagen and neurotoxin.
SGTC_1418 3966-3099 2.4 µM -0.0721048525836576 0.452686628420152 no 1864 0.471259232238399 2543 740335
SGTC_1634 st006576 41 µM -0.0724934230809178 0.452527399177169 no 1865 0.471104619660375 2553 3915356
SGTC_3143 9086658 49.47 µM -0.0740725025462139 0.451880399459614 no 1866 0.470476347463881 2613 25236626
SGTC_1608 st001473 40.5 µM -0.0747910940221494 0.451586011589146 no 1867 0.470190463956307 2552 7292267
SGTC_2799 7812892 81.82 µM -0.0750867549859468 0.451464894854181 no 1868 0.470072843032019 2583 20205235
SGTC_952 1185-0122 232 µM -0.0766439834026403 0.450827055159387 no 1869 0.469453384071111 2525 678600
SGTC_1157 4092-0394 27.6 µM -0.0770491229545497 0.450661131022011 no 1870 0.469292233307945 2689 3659885
SGTC_3305 9127027 53.8275 µM -0.0771078182411492 0.450637093192757 no 1871 0.469268886731635 2595 41905295
SGTC_2248 tofa 1.1 µM -0.0777387333530632 0.450378722231519 no 1872 0.469017941279704 2545 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2910 7948405 25.97 µM -0.0786020491689291 0.450025213143058 no 1873 0.468674578791445 2581 2971328
SGTC_2030 5175110 200 µM -0.0790653144256638 0.449835532405061 no 1874 0.468490336096647 2639 2831986
SGTC_1479 0549-0158 134 µM -0.07930825458201 0.449736066825409 no 1875 0.46839372038893 2573 5440202
SGTC_844 0330-0132 15.3 µM -0.0794681993925504 0.449670583272494 no 1876 0.468330112402068 2546 2828079
SGTC_926 2268-1401 59.4 µM -0.0795133256247027 0.449652108234978 no 1877 0.468312166428112 2542 2931578
SGTC_1952 st077036 64.1 µM -0.0796063925834798 0.449614006228255 no 1878 0.468275155404572 2541 2937007
SGTC_3180 9109287 49.47 µM -0.0798500862000538 0.449514239232091 no 1879 0.46817824422013 2632 18891271
SGTC_608 k048-0125 159 µM -0.0807491554358291 0.449146192259347 no 1880 0.467820722017845 2565 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_3309 9129340 25.759 µM -0.0823072116024165 0.448508483258093 no 1881 0.467201209925633 2612 17158987
SGTC_2692 st077426 47.7 µM -0.082757290115456 0.448324291792498 no 1882 0.467022265065728 2576 25238571
SGTC_228 caffeine 993.056 µM -0.0832926898120836 0.448105197743031 no 1883 0.466809406391352 2575 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1693 xanthone 101.9 µM -0.0846089134473799 0.447566645578063 no 1884 0.466286156287576 2607 7020 An insecticide.
SGTC_2403 6032726 181.2 µM -0.085110317846436 0.447361513997569 no 1885 0.466086843808768 2597 2881040
SGTC_1972 st070201 17.4 µM -0.085481940094335 0.447209487199215 no 1886 0.465939126315261 2596 2829099
SGTC_3034 9090421 49.47 µM -0.0857617354365937 0.447095030950372 no 1887 0.465827912531433 2542 17173761
SGTC_2879 9041815 71.43 µM -0.0869571535661585 0.446606069426291 no 1888 0.465352784772877 2562 4942971
SGTC_899 1083-0020 478 µM -0.0878831113013499 0.446227380953027 no 1889 0.464984789945206 2734 767123
SGTC_81 0411-0046 9.971 µM -0.0880246935330144 0.446169482452203 no 1890 0.464928524858553 2550 12925265
SGTC_3146 9095609 49.47 µM -0.0889748746516518 0.445780946062754 no 1891 0.464550939015672 2629 17173999
SGTC_119 0121-0043 24.815 µM -0.0890633628414794 0.445744765203576 no 1892 0.464515776931088 2560 1092378
SGTC_692 k241-0027 77.8 µM -0.089770833515886 0.445455512399725 no 1893 0.464234663033574 2645 3600480
SGTC_960 1222-0186 7.7 µM -0.090007742468071 0.445358657511161 no 1894 0.464140531102365 2658 3126296
SGTC_2725 haloperidol 53.21 µM -0.0902652469426019 0.445253386306329 no 1895 0.464038218150976 2564 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_361 000s-0510 1.45 µM -0.0903591161204535 0.445215012315604 no 1896 0.464000922176076 2621 660
SGTC_1851 st056236 18.9 µM -0.0904342069742931 0.445184315327465 no 1897 0.463971087407227 2567 5393171
SGTC_3101 9120531 49.47 µM -0.0905511321177399 0.445136517221344 no 1898 0.463924631625246 2592 24824904
SGTC_612 0302-0167 22.4 µM -0.0912210536444975 0.444862673812126 no 1899 0.463658473153829 2630 235821
SGTC_1427 4048-4900 550 nM -0.0913309408198966 0.444817757807739 no 1900 0.46361481675028 2656 24132586
SGTC_48 0382-0018 55 µM -0.0914315961215835 0.444776615921643 no 1901 0.463574828405808 2588 762596
SGTC_566 0958-0068 16.5 µM -0.0923225612593936 0.444412468482803 no 1902 0.463220881812683 2630 6815365
SGTC_1253 0550-0034 176 µM -0.0928186817859073 0.444209718778395 no 1903 0.463023804581012 2648 5969915
SGTC_1527 coumarin 137 µM -0.0936156607004351 0.443884047783835 no 1904 0.462707234404911 2804 323 A hepatotoxic, DNA x-linker.
SGTC_1203 3992-3522 103 µM -0.0937116511914797 0.443844825561137 no 1905 0.462669107348919 2721 5322312
SGTC_2541 muurolladie-3-one 83.07 µM -0.0944126716263512 0.443558401601909 no 1906 0.462390675133232 2739 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1853 st056710 91.2 µM -0.0950727752763023 0.44328872243296 no 1907 0.462128511142953 2750 269167
SGTC_3259 9138485 49.47 µM -0.0958970724180881 0.442952000442092 no 1908 0.461801159868779 2600 17646153
SGTC_475 α-linolenic acid 10 µM -0.0972449476966709 0.442401487805627 no 1909 0.461265937032977 2772 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2027 5150920 200 µM -0.0979808896209543 0.442100953947249 no 1910 0.460973734107288 2652 786715
SGTC_458 nppb 133 µM -0.0986723782068338 0.441818603693259 no 1911 0.460699200405597 2626 4549 A chloride channel blocker.
SGTC_2175 5807670 165.306 µM -0.099643154248436 0.441422264035826 no 1912 0.460313816077509 2593 241186
SGTC_2567 aureobasidin a 60 nM -0.100098053366715 0.44123656209719 no 1913 0.460133240380151 2824 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_605 1315-0399 119 µM -0.100223654239353 0.441185290749134 no 1914 0.460083383596441 2677 24020461
SGTC_1442 4112-3290 3 µM -0.100503109421049 0.441071218296757 no 1915 0.45997245718878 2583 704353
SGTC_1260 0700-1617 7.75 µM -0.10053800567779 0.441056974131878 no 1916 0.459958605753712 2650 2853078
SGTC_152 4469-0003 551.229 µM -0.101118800441724 0.440819913026115 no 1917 0.459728076972788 2588 697280
SGTC_2551 apiole 73.87 µM -0.101901553210397 0.440500452943635 no 1918 0.459417408549351 2570 10659 A possible DNA adduct former.
SGTC_1898 st060199 18.6 µM -0.102268903652751 0.440350541800646 no 1919 0.459271618576989 2589 688866
SGTC_649 1123-0311 367 µM -0.103100755181516 0.440011105179666 no 1920 0.458941502835398 2652 693629 YIL048W NEO1
SGTC_2362 9071156 126 µM -0.103497170228324 0.439849363703668 no 1921 0.458784197632962 2703 653133
SGTC_1855 st056195 39.6 µM -0.104253531114379 0.439540788440243 no 1922 0.45848407684392 2644 4028379
SGTC_888 0916-0002 6.97 µM -0.104713687472073 0.43935307475878 no 1923 0.458301500321601 2763 2802138 YIL048W NEO1
SGTC_2752 diclazuril 33.15 µM -0.105278217016454 0.439122802277858 no 1924 0.458077523606021 2671 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2420 aureobasidin a 50 nM -0.106098200327134 0.438788366520091 no 1925 0.457752219509132 2880 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_462 ag-879 158 µM -0.106261085464757 0.43872193790608 no 1926 0.457687603016464 2619 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2984 9022109 38.96 µM -0.106888971706318 0.438465886433694 no 1927 0.457438531184101 2558 6459207
SGTC_2273 7815444 169.05 µM -0.107775480099795 0.438104412944333 no 1928 0.457086896810415 2593 2824616
SGTC_2343 7990716 14.84 µM -0.107911060792922 0.438049134508886 no 1929 0.457033121558226 2616 6456862
SGTC_163 TUB2.036 7.546 µM -0.107919961060952 0.438045505768322 no 1930 0.45702959148018 2599 15992207 YJR013W GPI14
SGTC_1251 0490-5699 265 µM -0.107930150832324 0.438041351288968 no 1931 0.457025549955696 2613 3883818
SGTC_2695 st077686 51.995 µM -0.108069327144052 0.437984608293981 no 1932 0.456970349508577 2635 2876092
SGTC_54 0159-0055 9 µM -0.108523658694368 0.437799383549263 no 1933 0.456790157208992 2606 3319099
SGTC_1828 st055811 49 µM -0.110644818146665 0.436934796904462 no 1934 0.455949002956648 2618 5877589
SGTC_1444 4112-3581 28 µM -0.110779014636689 0.436880108370336 no 1935 0.455895793402407 2600 2877249
SGTC_1703 st026983 48.3 µM -0.11141513456439 0.436620889505875 no 1936 0.455643579566902 2623 1104023
SGTC_354 2783-3500 4.88 µM -0.112762179427302 0.436072058699855 no 1937 0.455109551744072 2629 6740761
SGTC_316 k060-0003 58.6 µM -0.113749578278077 0.435669837730405 no 1938 0.454718154880497 2746 6152314
SGTC_2418 pentamidine 31.67 µM -0.114554690916919 0.435341921021246 no 1939 0.454399047303826 2582 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1123 mangostin 811.285 nM -0.115611924425382 0.434911384811473 no 1940 0.453980055979226 2701 5281650 An antioxidant.
SGTC_810 3825-7150 143 µM -0.116091259366598 0.434716211085487 no 1941 0.453790107995332 2620 22330411 YGL099W LSG1
SGTC_2812 7970281 58.44 µM -0.116690507970124 0.434472233764212 no 1942 0.453552656214193 2717 2233435
SGTC_1090 efavirenz 20.7 µM -0.117329290569284 0.434212188101607 no 1943 0.453299557403686 2654 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_959 1222-0044 107 µM -0.117689780472622 0.434065446762433 no 1944 0.453156732252245 2634 6083612
SGTC_1692 fluoroquinolonic acid 71 µM -0.11830652672264 0.433814414567577 no 1945 0.452912393071705 2722 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2608 thymoquinone 42.66 µM -0.118449025870817 0.43375641740118 no 1946 0.452855941064963 2585 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3245 9134821 49.47 µM -0.119392551946949 0.433372438244263 no 1947 0.452482180887391 2609 17014901
SGTC_2807 7945238 51.95 µM -0.120003620344688 0.43312379022101 no 1948 0.452240140032837 2721 17148797
SGTC_3058 9093861 49.47 µM -0.120724296475635 0.432830576068776 no 1949 0.451954706969814 2737 17217477
SGTC_1943 st076331 65.2 µM -0.122459890275983 0.43212458477525 no 1950 0.451267404888466 2615 24208415
SGTC_2213 7173844 200 µM -0.122635839034233 0.432053025772873 no 1951 0.451197736597223 2638 892728
SGTC_3294 9122953 26.2835 µM -0.122728099464982 0.432015504009593 no 1952 0.451161205956487 2626 16459826
SGTC_1422 4031-0024 15.5 µM -0.122736022735891 0.432012281691473 no 1953 0.451158068746075 2605 782427
SGTC_2297 7971671 152.32 µM -0.124566824256 0.431267834012662 no 1954 0.450433247091371 2731 909016
SGTC_1073 triclabendazole 3.09 µM -0.125425077413757 0.430918931628999 no 1955 0.450093517984905 2678 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2496 diffractaic acid 79.83 µM -0.125908585141284 0.43072239679807 no 1956 0.449902143401293 2824 94870 An apoptosis inducer which activates caspases.
SGTC_1164 k060-0068 93.7 µM -0.126085395072524 0.430650531887082 no 1957 0.44983216412358 2625 5963676
SGTC_1287 0971-0001 34.6 µM -0.126619109536995 0.430433616028694 no 1958 0.449620935727378 2626 4665869
SGTC_2761 levamisole 97.89 µM -0.127255617971677 0.430174949395168 no 1959 0.449369043186218 2687 26879 An alkaline phosphatase inhibitor.
SGTC_2619 obliquin 87.91 µM -0.128834197346009 0.42953357004695 no 1960 0.448744422722724 2652 6708593 A bioactive alkalod. YER133W GLC7
SGTC_573 3702-0553 84.7 µM -0.129134203891696 0.429411697880103 no 1961 0.448625728895811 2654 1222756
SGTC_2740 felodipine 17.08 µM -0.129295458870098 0.429346193776417 no 1962 0.448561932285538 2709 3333 L-type calcium channel blocker
SGTC_1883 5-benzylidenerhodanine 20 µM -0.12959365747898 0.429225066316494 no 1963 0.448443960763863 2723 1273210
SGTC_3032 9089427 49.47 µM -0.129908754878714 0.429097081855148 no 1964 0.448319308799171 2730 17173707
SGTC_3236 9132701 49.47 µM -0.13047998564296 0.428865081621009 no 1965 0.448093343953972 2666 24282524
SGTC_3142 9086498 49.47 µM -0.130535388018229 0.428842581750948 no 1966 0.448071429031281 2707 25236367
SGTC_2359 9039622 200 µM -0.131346087184079 0.428513369177879 no 1967 0.447750767629094 2657 6463596
SGTC_1151 3909-8316 15.3 µM -0.131635631344085 0.428395801750839 no 1968 0.447636250505301 2748 800431
SGTC_534 k292-0788 63.4 µM -0.131788294616291 0.428333816430564 no 1969 0.447575872667971 2621 4146317
SGTC_631 k072-0230 41.5 µM -0.132261903800838 0.428141529851342 no 1970 0.44738856948175 2743 5773147
SGTC_2592 piperlongumine 83.33 µM -0.133062160547789 0.427816662292388 no 1971 0.447072110243858 2731 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2813 7971799 71.43 µM -0.133787762394618 0.427522143488039 no 1972 0.446785202194441 2753 2234054
SGTC_1161 k007-0610 110 µM -0.13405299625348 0.427414496226387 no 1973 0.446680333813079 2715 5843850
SGTC_1867 st057372 64 µM -0.134580555022956 0.42720039839404 no 1974 0.44647175828351 2639 688837
SGTC_980 1473-0395 201 µM -0.135578385315082 0.426795510144234 no 1975 0.446077296836887 2647 768876
SGTC_2506 ethyl hematommate 54.16 µM -0.13558905862512 0.426791179665757 no 1976 0.446073077760535 2712 3940691 An allergen.
SGTC_1227 3909-8010 46.6 µM -0.135931345695654 0.426652308330067 no 1977 0.445937777586934 2667 15982272
SGTC_2717 st081029 62.2815 µM -0.136858538343952 0.426276177171413 no 1978 0.445571305995712 2689 5292846
SGTC_1290 0986-0249 10.2 µM -0.137117986922271 0.426170939520625 no 1979 0.44546876762282 2687 53329
SGTC_666 0272-0154 136 µM -0.137484036804531 0.42602247114298 no 1980 0.445324104855388 2690 6870312
SGTC_3045 9092950 49.47 µM -0.138082828887228 0.425779626068084 no 1981 0.445087478166842 2670 44120432
SGTC_517 1365-0151 113 µM -0.138654614576576 0.425547759929946 no 1982 0.444861541945259 2806 768657
SGTC_1221 2958-7315 257 µM -0.138962653509856 0.425422857014778 no 1983 0.444739830416532 2736 4562705
SGTC_442 cape 100 µM -0.139014315467199 0.425401909976147 no 1984 0.444719418390405 2705 5281787
SGTC_1850 st056238 17 µM -0.139567815872822 0.425177498982902 no 1985 0.444500735445915 2625 5393177
SGTC_2566 crystal violet carbinol 226 nM -0.139599067879808 0.425164828903448 no 1986 0.444488388567196 2831 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2780 5215298 71.43 µM -0.139969923044181 0.425014484003006 no 1987 0.444341877172863 2718 2834131
SGTC_3218 9131285 49.47 µM -0.140704499370288 0.4247167185458 no 1988 0.444051695239042 2712 17156417
SGTC_2488 5268135 45.7 µM -0.141585256189676 0.424359754481235 no 1989 0.44370380672839 2775 1270356 YLR208W SEC13
SGTC_465 cgp-37157 41 µM -0.14160695462812 0.424350961050366 no 1990 0.443695236648668 2713 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2335 9018011 154.17 µM -0.141944521433039 0.424214164797434 no 1991 0.443561913654269 2769 6458208
SGTC_1408 3909-7976 48.8 µM -0.142036721373627 0.4241768030942 no 1992 0.443525500128804 2691 24152374
SGTC_1181 1222-0449 220 µM -0.142200380519092 0.424110486026842 no 1993 0.443460865616901 2813 658318
SGTC_444 curcumin 90.4 µM -0.142706556697914 0.423905389681791 no 1994 0.443260969113591 2769 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1112 tnp00069 1.16933 µM -0.142714388828614 0.423902216360796 no 1995 0.443257876201967 2780 145826
SGTC_1793 st048256 72.231 µM -0.14389898487659 0.423422314048386 no 1996 0.442790118648308 2643 672022
SGTC_590 k048-0076 22.4 µM -0.143949099686272 0.423402014088236 no 1997 0.442770331731173 2762 6832814
SGTC_1939 st074455 53.6 µM -0.14478596910222 0.423063054246037 no 1998 0.44243993026155 2883 1644229
SGTC_688 0527-0193 473 µM -0.145125461240476 0.42292556490285 no 1999 0.442305907965799 2721 4007154
SGTC_2163 5671233 125 µM -0.145545571650058 0.42275543933802 no 2000 0.442140068904121 2729 701023
SGTC_351 caspofungin 25 nM -0.14751029478118 0.421960007758134 no 2001 0.44136462727895 2703 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1486 3970-0793 4.53 µM -0.148824588610307 0.42142808437253 no 2002 0.440846023899635 2770 2844330
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.149650176562899 0.421094024162698 no 2003 0.440520309363033 2641 2346 DNA damaging agent; causes G2/M arrest.
SGTC_83 0170-0301 39.027 µM -0.151679407780027 0.420273171907141 no 2004 0.439719899721245 2663 3089716
SGTC_1587 estradiol valerate 56.1 µM -0.152114234123376 0.420097323578039 no 2005 0.439548418823382 2700 13791 A steroid.
SGTC_2666 tannic acid 100 µM -0.153221867248008 0.419649457276261 no 2006 0.439111656856911 2734 16134267 A thiamine antagonist.
SGTC_1043 0916-0009 19.3 µM -0.154466811032838 0.419146194279292 no 2007 0.438620839037751 2676 3101130
SGTC_2098 5376439 882.5 nM -0.154727694761322 0.419040749924736 no 2008 0.438517997829409 2772 2844116
SGTC_2767 sibutramine 71.45 µM -0.157542562494995 0.417903404086472 no 2009 0.437408633328432 2801 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2240 6690706 185.951 µM -0.159853751796874 0.416970081858829 no 2010 0.436498140322456 2662 805876
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.160812394433887 0.416583092362002 no 2011 0.436120581474005 2794 5379071
SGTC_213 1246-0773 967 nM -0.161527894563502 0.416294308467631 no 2012 0.435838821565948 2726 6251622
SGTC_986 1493-0483 84 µM -0.162048035363845 0.416084402145569 no 2013 0.43563401348957 2684 40079
SGTC_1916 st067606 49.2 µM -0.16221892548343 0.416015443507859 no 2014 0.435566728403572 2809 19590279
SGTC_183 3914-0051 30.55 µM -0.16238797286708 0.415947231006234 no 2015 0.435500170698749 2788 1596232
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.162555885681734 0.415879478822488 no 2016 0.43543406150762 2826 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2616 abietic acid 100 µM -0.16318305438997 0.415626440752541 no 2017 0.435187154002007 2752 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_759 3486-0358 89.3 µM -0.164330594987042 0.415163543588507 no 2018 0.434735448878823 2713 875103
SGTC_2886 9058944 51.95 µM -0.166016079376901 0.414483863243307 no 2019 0.434072148127524 2680 4949929
SGTC_255 tunicamycin 200.472 nM -0.16710210801937 0.414046052020021 no 2020 0.433644853688821 2794 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1720 st037298 9.481 µM -0.167339077741403 0.413950536483052 no 2021 0.433551629010172 2795 597396
SGTC_790 1575-0012 79.1 µM -0.167888477877484 0.413729109009679 no 2022 0.433335507394087 2853 378741 YLR208W SEC13
SGTC_2883 9059145 45.46 µM -0.168134791302086 0.413629844984238 no 2023 0.433238619719033 2673 16476510
SGTC_2215 7188065 200 µM -0.169742455301493 0.412982094101103 no 2024 0.432606342013409 2832 940217
SGTC_3281 9140613 49.47 µM -0.170390448262055 0.412721075313764 no 2025 0.432351541743305 2745 16013766
SGTC_841 0251-0215 91.2 µM -0.170663083434856 0.412611266353645 no 2026 0.432244346024326 2751 3888614
SGTC_3227 9130768 49.47 µM -0.171945990844094 0.412094643132411 no 2027 0.431739994762881 2727 17720899
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.172182717482552 0.411999330596341 no 2028 0.431646942207539 2731 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2440 5628896 157.78 µM -0.172710476856814 0.411786859117921 no 2029 0.431439504105786 2734 5522048
SGTC_2712 st079126 47.7 µM -0.174949972008158 0.410885545657439 no 2030 0.430559471876265 2697 3152970
SGTC_1244 0416-0015 52.5 µM -0.17564293496225 0.410606748908968 no 2031 0.430287234725413 2741 96201
SGTC_2768 sulfasalazine 50.2 µM -0.175778409228044 0.41055224941457 no 2032 0.430234016227138 2760 5384001 An antioxidant and salicylic acid derivative.
SGTC_981 1488-1094 54.9 µM -0.176375764098984 0.410311962109634 no 2033 0.429999371811647 2691 3449522
SGTC_3279 9140807 49.47 µM -0.177308966437094 0.409936646836266 no 2034 0.429632854092827 2697 45595718
SGTC_2096 5468907 200 µM -0.179897270658356 0.408896115493735 no 2035 0.428616608972692 2877 759785
SGTC_1812 st052057 4.327 µM -0.180080499567303 0.408822479370289 no 2036 0.428544685713519 2697 3645418
SGTC_1677 st019204 53.9 µM -0.180112979780802 0.408809426541947 no 2037 0.428531936429209 2841 3945625
SGTC_1188 1403-0014 4.57 µM -0.180997575118626 0.40845397301253 no 2038 0.428184739677805 2751 9614867
SGTC_1887 st057648 70.8 µM -0.181671836501086 0.40818308772183 no 2039 0.427920134676138 2872 688672
SGTC_2317 5986382 200 µM -0.182427159589476 0.407879687905383 no 2040 0.427623756570434 2792 877883
SGTC_849 0386-0493 241 µM -0.1827418259723 0.407753308317839 no 2041 0.427500297968886 2739 726119
SGTC_3297 9117502 71.43 µM -0.182853637631194 0.407708403666347 no 2042 0.427456430641167 2716 7453720
SGTC_2170 morpholine 200 µM -0.183438437516466 0.407473562102999 no 2043 0.427227009369056 2840 121171 Reacts with secondary amines.
SGTC_278 4092-0821 23.9 µM -0.188151155923552 0.405582268361504 no 2044 0.425379080247915 2819 877900
SGTC_1490 4089-0339 670 nM -0.18871855167463 0.405354710491968 no 2045 0.425156705360271 2745 742542
SGTC_3228 9131799 49.47 µM -0.188833631689312 0.405308560780172 no 2046 0.425111605870817 2787 17015818
SGTC_2220 6782180 200 µM -0.190155887633695 0.404778400594486 no 2047 0.424593488464247 2751 833803
SGTC_3335 9143315 29.6265 µM -0.190205300348637 0.40475859188539 no 2048 0.424574128932091 2791 4899691
SGTC_2528 xanthyletin 44.79 µM -0.190445356611128 0.404662360925143 no 2049 0.424480079273838 2769 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_3176 9106582 49.47 µM -0.191858720655449 0.40409590509828 no 2050 0.42392643641238 2748 17018027
SGTC_531 3788-1495 174 µM -0.192016273265445 0.404032772727718 no 2051 0.423864729195049 2714 2896655
SGTC_1680 diphenhydramine 100 µM -0.192402088608913 0.403878184531519 no 2052 0.423713628246572 2807 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_543 3844-1095 191 µM -0.193956501174792 0.403255516010809 no 2053 0.423104971038813 2848 4230703
SGTC_418 lividomycin a 100 µM -0.194614580258031 0.402991975659837 no 2054 0.422847343955661 2760 72394 An antibiotic.
SGTC_166 k072-0058 166.424 µM -0.195544488172343 0.402619651403615 no 2055 0.422483356653019 2768 5846229
SGTC_2651 TUB2.036 5 µM -0.19587064377582 0.402489083414019 no 2056 0.42235570752462 2837 15992207 YFL037W TUB2
SGTC_1166 k206-0078 225 µM -0.196632708836525 0.402184052729251 no 2057 0.422057486168406 2740 5404595
SGTC_1101 ebselen 5.29 µM -0.197179874833725 0.401965076106156 no 2058 0.421843389499758 2890 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1712 st032288 53.4 µM -0.198048103272818 0.401617673004922 no 2059 0.421503714033425 2805 2883011
SGTC_16 erodoxin 22.806 µM -0.198370567999768 0.401488665401985 no 2060 0.421377571592909 2780 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2837 9008476 45.46 µM -0.198678867218325 0.40136533499545 no 2061 0.421256977990913 2962 2992805
SGTC_817 1391-0715 46 µM -0.199530259607753 0.401024799508231 no 2062 0.420923987731458 2821 1353946
SGTC_1594 piperine 70.1 µM -0.200151579105562 0.400776334814252 no 2063 0.420681017557794 2755 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2085 5307070 144.047 µM -0.203155188750207 0.399575763743044 no 2064 0.419506868307767 2743 2840351
SGTC_177 1327-0068 8.361 µM -0.203594236529307 0.399400351432453 no 2065 0.419335298699118 2755 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_3132 9126706 49.47 µM -0.204427320888353 0.399067565939491 no 2066 0.419009790988934 2978 850858
SGTC_1134 3477-0009 42.5 µM -0.205799884998896 0.398519438892334 no 2067 0.418473615517478 3033 3973534
SGTC_2893 9048488 25.97 µM -0.205940406466978 0.398463333577901 no 2068 0.418418731044632 2785 6467338
SGTC_386 1509-0011 3.07 µM -0.208039490578373 0.397625493037909 no 2069 0.417599066419528 2764 3107280
SGTC_3318 9139014 38.6185 µM -0.209076800150371 0.39721162933327 no 2070 0.41719414263457 2765 16643984
SGTC_2429 5902844 64.44 µM -0.210324782009428 0.396713865399763 no 2071 0.41670709730075 2942 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_624 k048-0052 28 µM -0.210655760764141 0.396581881030412 no 2072 0.416577948843582 2829 6835531
SGTC_806 3966-4455 5.86 µM -0.212271052515533 0.395937921561708 no 2073 0.415947788785777 2776 714982
SGTC_2158 5657123 3.6195 µM -0.212490483081172 0.395850464250445 no 2074 0.415862200834047 2751 2858827
SGTC_409 arachidonic acid 100 µM -0.212575713358528 0.395816495870913 no 2075 0.415828958205446 2785 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_348 k064-0012 10.7 µM -0.212579198096709 0.395815107051377 no 2076 0.415827599055053 2750 5066323
SGTC_3118 9124250 49.47 µM -0.214935166701461 0.394876454828747 no 2077 0.414908933256402 2854 1504786
SGTC_2061 5245884 80.95 µM -0.215267012910306 0.394744291337392 no 2078 0.414779573302589 2775 573863
SGTC_1633 st005664 67.9 µM -0.217032817814871 0.39404123304887 no 2079 0.41409138475509 2768 2063822
SGTC_2073 5212005 126 µM -0.217057125462688 0.394031557319877 no 2080 0.414081913151442 2744 691789
SGTC_889 0919-1524 82.7 µM -0.217322456912898 0.393925945629185 no 2081 0.413978528598333 2856 3905452
SGTC_3016 9080866 49.47 µM -0.217986721373891 0.393661578131437 no 2082 0.413719728732552 2827 17066299
SGTC_423 5-fluorouracil 457 µM -0.218914722630656 0.393292329343939 no 2083 0.413358238811353 2742 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_669 0108-0021 26.2 µM -0.219237595298203 0.393163881808562 no 2084 0.413232485479016 2788 17201
SGTC_1904 st060225 78 µM -0.221504316265414 0.392262446674204 no 2085 0.412349888086629 2799 66595
SGTC_14 0354-0009 295 µM -0.222189414647928 0.391990108568545 no 2086 0.412083217034486 2769 1713507
SGTC_2772 vinpocetine 57.06 µM -0.222357967801794 0.391923113965432 no 2087 0.412017614795778 2975 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2909 7941780 10.49 µM -0.222364466795151 0.391920530883129 no 2088 0.41201508538468 2862 1243215
SGTC_2876 9059903 25.97 µM -0.222880128050024 0.391715591957159 no 2089 0.411814401455308 2764 6916095
SGTC_809 3998-0021 90 µM -0.222916725662851 0.391701048132293 no 2090 0.4118001593516 2964 715485
SGTC_1915 st067105 30.6 µM -0.223532907501372 0.391456201331349 no 2091 0.411560387247787 2764 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1235 benzylparaben 21.5 µM -0.224154465583781 0.391209261782027 no 2092 0.411318556566956 2899 7180
SGTC_3000 9075062 71.4286 µM -0.225056341750545 0.390851032319374 no 2093 0.410967721975081 2844 17057871
SGTC_2826 7992541 19.48 µM -0.225501171959379 0.390674377746856 no 2094 0.410794706878183 2741 2985066
SGTC_902 1120-0002 2.07 µM -0.226092478056806 0.390439588418716 no 2095 0.410564747387821 2785 3280475
SGTC_615 k087-0205 167 µM -0.226502342068258 0.390276867557048 no 2096 0.410405368927651 2827 9642773
SGTC_1583 clindamycin 39.6 µM -0.22699884133669 0.390079777219436 no 2097 0.410212321566827 2796 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2398 5228213 48.84 µM -0.228223135046258 0.389593902443581 no 2098 0.409736388408976 2991 80771 YMR134W ERG29
SGTC_1505 k297-0037 20.6 µM -0.228247194993008 0.389584355708165 no 2099 0.40972703665124 2816 4089396
SGTC_224 benfluorex 43.875 µM -0.229299425358439 0.389166906945883 no 2100 0.409318100040844 2913 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_774 k060-0086 136 µM -0.230343963227973 0.388752636497671 no 2101 0.40891225060034 2801 5911235
SGTC_1082 camptothecin 424.86 nM -0.230410190011507 0.388726374787522 no 2102 0.408886521835149 2702 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2006 4011487 200 µM -0.232394363539922 0.387939802733893 no 2103 0.408115863174507 2960 45595294
SGTC_1000 4048-0884 8.67 µM -0.232522556682983 0.387888999791701 no 2104 0.408066084779479 2945 13040088
SGTC_642 0335-0876 158 µM -0.233486690981165 0.387506974915599 no 2105 0.407691751526588 2805 6812350
SGTC_2425 5628681 7.85 µM -0.233535303102301 0.387487715915802 no 2106 0.407672879690063 2901 5714958
SGTC_275 trichlorophene 5.69 µM -0.233902287623231 0.387342334061023 no 2107 0.407530418602355 2906 62616
SGTC_514 4466-0038 2.65 nM -0.234303129526251 0.387183557570207 no 2108 0.407374828264442 2862 5722064
SGTC_2333 9017922 200 µM -0.236359506059412 0.386369308669167 no 2109 0.406576857760494 2964 3163164
SGTC_1657 st012939 43.4 µM -0.238197049359669 0.385642132601364 no 2110 0.405864132769546 2979 24207257
SGTC_555 4296-0685 37 µM -0.238815817926539 0.3853973559052 no 2111 0.405624202074068 2852 2908540 YHR072W ERG7
SGTC_825 1988-2224 89.6 µM -0.239485864624894 0.385132345731744 no 2112 0.405364428003029 2823 1180859
SGTC_404 fumagillin 50 µM -0.240761203275622 0.384628084836405 no 2113 0.404870100243558 2881 12015870 A methionine aminopeptidase binder.
SGTC_320 4092-0846 5.34 µM -0.241599559326458 0.384296710357384 no 2114 0.404545231789723 2924 1359356
SGTC_1698 5-fluorocytosine 1.055 µM -0.241945457940843 0.384160012674569 no 2115 0.404411212974896 2955 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_634 1611-4317 11.2 µM -0.242815243726848 0.383816340678691 no 2116 0.404074263066936 2825 2843522
SGTC_2372 9071633 200 µM -0.243938863001796 0.383372508616532 no 2117 0.403639084923684 2953 21321366
SGTC_3117 9124945 49.47 µM -0.245151546951449 0.382893667508559 no 2118 0.403169545834184 2799 17592065
SGTC_1737 st035557 69.7 µM -0.246262033155834 0.382455337175735 no 2119 0.402739699094615 2767 5716916
SGTC_1985 st071382 65.5 µM -0.246583546910692 0.382328457573946 no 2120 0.402615269544505 2863 6123237
SGTC_1014 4130-3005 69.3 µM -0.24660878714163 0.382318497506884 no 2121 0.402605501699986 2827 743608
SGTC_380 3970-0968 6 µM -0.247853930446869 0.381827247330438 no 2122 0.402123712997841 2860 2891601
SGTC_3311 9131146 2.8755 µM -0.248539856361353 0.381556708105437 no 2123 0.401858368167952 2880 4900406 YPR165W RHO1
SGTC_856 0433-0016 11.3 µM -0.248767688930173 0.381466860397104 no 2124 0.401770243003491 2914 3911780
SGTC_1815 st051655 58.2 µM -0.249348420627976 0.381237872819969 no 2125 0.401545639789357 2934 5984156
SGTC_389 tpck 16.7 µM -0.249461654974319 0.381193228369875 no 2126 0.401501849172715 2920 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1768 st044301 37.178 µM -0.250688450706902 0.380709646030111 no 2127 0.401027495306803 2900 3931349
SGTC_935 2996-0153 430 µM -0.251345623018966 0.380450676289293 no 2128 0.400773452463133 3026 23738523
SGTC_2605 digitonin 300 nM -0.252039035824349 0.380177483458416 no 2129 0.400505445641432 2945 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1025 k007-0731 70 µM -0.253021697287736 0.379790433977137 no 2130 0.40012572329982 2855 6256118
SGTC_2708 st078559 56 µM -0.253219706661885 0.379712456851796 no 2131 0.400049219470646 2927 17250902
SGTC_187 1488-2104 32.728 µM -0.254243018136839 0.379309549472674 no 2132 0.399653909253889 2918 2852859
SGTC_1456 k015-0012 13 µM -0.254569935532992 0.379180860221229 no 2133 0.399527641123772 2997 2989616
SGTC_2817 7995342 71.43 µM -0.256495329729918 0.378423211343962 no 2134 0.398784193095037 2818 18879975
SGTC_625 k213-0058 121 µM -0.257779474678253 0.377918155619621 no 2135 0.398288553050398 2916 3655420
SGTC_1086 cerivastatin 2.18 µM -0.25825784461006 0.377730065441144 no 2136 0.398103959018318 2853 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_284 0988-0104 32.6 µM -0.26021557221254 0.376960609420406 no 2137 0.397348746511624 2951 4666532
SGTC_2264 7948757 110.76 µM -0.260822779028277 0.376722054805219 no 2138 0.397114588586146 2814 2971411
SGTC_3115 9123671 49.47 µM -0.261178467479309 0.376582336590465 no 2139 0.396977441220501 2834 3286988
SGTC_1154 4088-0362 150 µM -0.262777975872969 0.375954232694671 no 2140 0.396360855917113 2845 6618304
SGTC_3177 9107506 49.47 µM -0.263903657531287 0.375512390559412 no 2141 0.395927078614652 2987 8897194
SGTC_3050 9093513 49.47 µM -0.264593498620714 0.375241701153755 no 2142 0.395661314518496 2873 25236664
SGTC_1050 3232-1156 69.3 µM -0.265515332370027 0.374880075154497 no 2143 0.395306250039376 2903 700529
SGTC_995 3931-2021 34.6 µM -0.265520569374344 0.374878021044882 no 2144 0.395304233140312 2975 730143
SGTC_1369 1866-0067 208 µM -0.26622037696474 0.374603567541298 no 2145 0.395034745286503 3018 3531355
SGTC_199 4063-0024 41.6 µM -0.266513285849415 0.374488712141749 no 2146 0.394921964340556 2993 306215
SGTC_847 0342-0274 5.54 µM -0.267136168342569 0.37424450455818 no 2147 0.394682160413039 3001 18097
SGTC_2902 5787006 60.46 µM -0.268105940069911 0.373864395877829 no 2148 0.394308886826314 2887 591003
SGTC_2569 tetrandrine 100 µM -0.268247438604032 0.373808944800356 no 2149 0.39425443091241 2935 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2095 5432005 200 µM -0.268846435498754 0.373574236164894 no 2150 0.394023929004834 2886 783734
SGTC_249 wiskostatin 11.211 µM -0.269612865190802 0.37327398969216 no 2151 0.393729050887342 2892 2775510 A n-wasp and actin depolymerizer.
SGTC_3141 9094609 49.47 µM -0.271542651241905 0.37251834302319 no 2152 0.392986850268241 2838 25236309 YDL196W YDL196W
SGTC_3338 9144300 39.5675 µM -0.272392317880814 0.372185794237762 no 2153 0.392660189454522 2956 4901274
SGTC_3040 9091894 49.47 µM -0.272669705317659 0.372077248922872 no 2154 0.392553562098107 2884 25236966
SGTC_947 3447-0010 211 µM -0.273011357911698 0.371943569786111 no 2155 0.392422242386263 2861 748350
SGTC_698 k064-0052 127 µM -0.276397045417403 0.370619681392281 no 2156 0.391121562892585 2882 5088751
SGTC_585 0kpi-0023 191 µM -0.276513265658655 0.370574263457933 no 2157 0.391076936084248 3024 64601
SGTC_2745 rifampicin 24.3 µM -0.276602471181096 0.370539403881678 no 2158 0.39104268349064 2953 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_584 0986-0246 15.4 µM -0.277781448745304 0.370078785072353 no 2159 0.390590066355041 2892 53315 YDR232W HEM1
SGTC_3027 9089541 49.47 µM -0.28070524827441 0.368937280833621 no 2160 0.389468241500746 3000 9943819
SGTC_1367 1812-0510 76.9 µM -0.280763599515373 0.368914511176855 no 2161 0.389445862206119 2951 1142582 YDR527W RBA50
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.280896879645705 0.36886250470573 no 2162 0.389394747011142 2857 88881 An O-methylated flavonoid and antioxidant.
SGTC_1524 corynanthine 62.1 µM -0.280924088721581 0.368851887904224 no 2163 0.389384312103327 3077 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2699 st077704 54.6 µM -0.281310153692529 0.36870125869264 no 2164 0.389236261561103 2959 645852
SGTC_1672 st016598 6.51 µM -0.282590487838008 0.368201861025621 no 2165 0.38874538642693 2943 4665860 YNL267W PIK1
SGTC_452 diindolylmethane 8 µM -0.282641121955254 0.368182115627059 no 2166 0.388725977148466 3014 3071 Inhibits expression of several cancer promoting factors.
SGTC_297 0986-0032 24 µM -0.282948694355632 0.368062181459227 no 2167 0.388608083198526 2876 2847425
SGTC_3035 9091303 49.47 µM -0.283629366173576 0.367796807382354 no 2168 0.388347214974842 2912 25237002
SGTC_2130 NSC 7 2.4545 µM -0.284660065347877 0.367395087997488 no 2169 0.387952294277984 3030 21448
SGTC_1659 st012954 42.1 µM -0.285742780082122 0.36697325157558 no 2170 0.387537568176802 3042 24207262
SGTC_2198 6589944 200 µM -0.286380027982902 0.366725048486939 no 2171 0.387293534890103 2938 5290268
SGTC_319 1348-1596 45.5 µM -0.287222607058558 0.366396956054943 no 2172 0.386970938666998 3102 5380505
SGTC_3248 9135562 49.47 µM -0.287599422428966 0.366250259242752 no 2173 0.38682669352178 2965 17650701
SGTC_2655 perillic acid 100 µM -0.288313799757403 0.365972200906113 no 2174 0.386553272383857 2930 5702197 An apoptosis inducer.
SGTC_1558 st069300 45.6 µM -0.288848145135417 0.365764262722183 no 2175 0.386348793569619 3027 24208000
SGTC_779 1360-0071 233 µM -0.289042889601052 0.365688488560333 no 2176 0.386274278232177 3105 7566
SGTC_3092 9117248 49.47 µM -0.290069763690457 0.365289023379721 no 2177 0.385881433442984 2939 17141857
SGTC_1492 4158-0558 28.5 µM -0.290166694591647 0.365251323745875 no 2178 0.385844357232437 3020 3967268
SGTC_318 1488-0629 67.2 µM -0.291513084135943 0.364727803119975 no 2179 0.385329469256679 2989 3662576
SGTC_777 1315-0167 517 µM -0.291519782480821 0.364725199212274 no 2180 0.385326908171635 3012 4221767
SGTC_2884 9058502 51.95 µM -0.293480689650676 0.363963186947638 no 2181 0.384577378719 3033 6471554
SGTC_2468 5987765 72.9 µM -0.296858721139569 0.362651739686341 no 2182 0.383287186008289 2976 26772094
SGTC_2848 9016370 25.97 µM -0.298877391747684 0.361868802041182 no 2183 0.382516798934717 3035 7894410
SGTC_771 0250-0039 27.3 µM -0.300314973044887 0.361311590824477 no 2184 0.381968456606846 2944 3005115
SGTC_2757 clomiphene 4.22 µM -0.300495388798507 0.361241681833413 no 2185 0.381899656605874 3163 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2157 5649910 96.377 µM -0.300870254069825 0.361096440750376 no 2186 0.381756716876737 2937 2858091
SGTC_2892 9047358 58.44 µM -0.301055686728087 0.361024602498564 no 2187 0.381686015581097 2983 6466771
SGTC_2716 st080858 38.6235 µM -0.301449044394012 0.360872228490733 no 2188 0.38153605023274 3086 5296050
SGTC_1981 st071826 47 µM -0.301870124058603 0.360709140348667 no 2189 0.381375535737657 3023 11838600
SGTC_1060 3448-7350 82 µM -0.302659440886476 0.360403498725979 no 2190 0.381074705160308 3066 570178
SGTC_282 k297-0036 65.7 µM -0.306059985227058 0.359087751706167 no 2191 0.379779487017357 3083 5061378
SGTC_1317 1273-0028 910 nM -0.309237043470536 0.357859984602582 no 2192 0.378570608638838 2963 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2074 5212007 75.395 µM -0.309276734190558 0.357844655476636 no 2193 0.378555513708279 3045 758611
SGTC_2277 7947813 106.88 µM -0.310307420572621 0.35744666993237 no 2194 0.378163594345744 3161 1246798
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.310678573203254 0.357303392318183 no 2195 0.378022493917713 3032 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1423 4048-0112 5.59 µM -0.311553133053846 0.356965861867048 no 2196 0.377690078437519 3038 X1423
SGTC_3044 9093193 49.47 µM -0.312399539006631 0.35663930379678 no 2197 0.377368450335022 3059 25236277
SGTC_2638 epoxomicin 18 µM -0.313470347074836 0.356226318051935 no 2198 0.376961672925383 3054 9915668 A protesome inhibitor.
SGTC_2120 5538279 151.968 µM -0.314032789076269 0.356009464763045 no 2199 0.376748067725272 2985 2058197
SGTC_3212 9128307 49.47 µM -0.316491356544223 0.355062095130289 no 2200 0.375814792374026 2901 27243542
SGTC_298 1391-0729 10 µM -0.316514130805216 0.355053323609505 no 2201 0.375806150620921 2956 3237558
SGTC_1027 k015-0025 8.67 µM -0.316856735008525 0.354921378659588 no 2202 0.37567615607627 2939 3598955
SGTC_912 3474-0017 2.18 µM -0.317689877582787 0.354600588452013 no 2203 0.375360095133949 3125 3360550
SGTC_2380 9035439 200 µM -0.31784851921191 0.354539517329672 no 2204 0.375299922324043 3108 6462575
SGTC_1979 st071809 45.3 µM -0.318271934190999 0.354376536634923 no 2205 0.3751393357752 3090 4976333
SGTC_1240 0356-0016 42.1 µM -0.319812138182925 0.353783907137319 no 2206 0.374555372779957 2989 4305613
SGTC_746 1095-0025 46.6 µM -0.319909097710248 0.353746611526111 no 2207 0.374518620520473 3153 6749286
SGTC_2054 5233173 129 µM -0.320277228934186 0.353605022145227 no 2208 0.374379091710015 3125 6889
SGTC_1751 st044839 27.194 µM -0.321058302676101 0.353304675304867 no 2209 0.374083104246267 2980 5291326
SGTC_1774 st048371 48.465 µM -0.322513685481931 0.352745279697122 no 2210 0.373531785837566 2958 4242727
SGTC_2656 pseudo-anisatin 100 µM -0.324096070433728 0.352137430229782 no 2211 0.372932650925007 3004 6708809 A neurotoxin.
SGTC_900 1112-0045 141 µM -0.324605977063492 0.351941637603976 no 2212 0.37273965148375 3016 56211 YIL048W NEO1
SGTC_3207 9114163 49.47 µM -0.324878004540249 0.351837201250917 no 2213 0.372636702263186 3239 849233
SGTC_1401 3807-4679 7.6 µM -0.325693289109717 0.351524265486641 no 2214 0.372328211073833 2989 3291456
SGTC_376 3970-0862 59.1 µM -0.325821659432925 0.351475001466096 no 2215 0.37227964516905 3093 3135186
SGTC_578 3460-0051 92 µM -0.326585122886361 0.351182062576103 no 2216 0.371990848643801 3105 2876744
SGTC_2593 nobiletin 86.24 µM -0.32669552922979 0.351139707268946 no 2217 0.371949091017278 3046 72344 An anti-infammatory.
SGTC_1165 k072-0275 30.3 µM -0.327161427814488 0.350960994452121 no 2218 0.371772896547894 3106 6153523 YGL055W OLE1
SGTC_708 3448-5400 146 µM -0.327739561929099 0.350739275336378 no 2219 0.371554293959812 3083 3462195
SGTC_2946 9065502 71.43 µM -0.327914030839154 0.350672375076276 no 2220 0.371488332355405 3019 16489101
SGTC_97 0535-0701 19.132 µM -0.328503708077698 0.350446297093772 no 2221 0.371265420537741 3015 2832013 YGL099W LSG1
SGTC_3085 9117376 49.47 µM -0.328722634466241 0.350362375780988 no 2222 0.371182672218333 3058 16480349
SGTC_3074 9116018 49.47 µM -0.329289785834243 0.350145002954583 no 2223 0.370968331874645 2954 17027303
SGTC_2152 5568786 200 µM -0.331306838141269 0.34937232290692 no 2224 0.370206363311579 3012 5399883
SGTC_1740 st038286 13.222 µM -0.331407416920006 0.349333810106653 no 2225 0.37016838162992 3203 716786
SGTC_2836 9010338 19.48 µM -0.33802859581215 0.346801911738087 no 2226 0.367670819252012 2994 2994051
SGTC_2269 7935389 174.42 µM -0.33968697396941 0.346168822625474 no 2227 0.367046136167576 2970 97605
SGTC_1431 4049-0260 9.09 µM -0.341190150669441 0.345595353112111 no 2228 0.366480218771663 2985 3854841
SGTC_1514 1189-1591 158 µM -0.341375818266286 0.345524544533006 no 2229 0.366410338568751 3184 767698 YMR146C TIF34
SGTC_3328 9140624 29.0385 µM -0.342417498812629 0.345127376153322 no 2230 0.366018360707338 3158 4904392
SGTC_221 trifluoperazine 10.304 µM -0.343484190774571 0.344720848221296 no 2231 0.365617116074541 3039 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2171 5739187 198.077 µM -0.344698530456045 0.344258268309202 no 2232 0.365160511516595 2934 2262761
SGTC_1428 4049-0204 61.7 µM -0.345179558926169 0.344075093904029 no 2233 0.364979692532346 3114 X1428
SGTC_1349 flufenamic acid 69 µM -0.349956794663327 0.342257926602194 no 2234 0.363185561332479 3000 3371 A non-steroidal anti-inflammatory.
SGTC_2899 9053889 58.44 µM -0.350177349853986 0.342174119453854 no 2235 0.363102802069376 3132 6470052
SGTC_3178 9107506 49.47 µM -0.357359500361107 0.339449295633649 no 2236 0.360411345859983 3178 8897194
SGTC_2289 7946404 165.07 µM -0.358051277417616 0.339187283341759 no 2237 0.360152470008773 2995 1246120 YPR165W RHO1
SGTC_1946 st076057 65.1 µM -0.358053161031133 0.339186570024503 no 2238 0.360151765213008 3000 953009
SGTC_1305 1181-0477 144 µM -0.359621813263576 0.338592727734816 no 2239 0.35956498443679 3167 6252086
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.360835920417401 0.338133380288287 no 2240 0.359111054333848 3072 688788
SGTC_1618 st003135 44.5 µM -0.361551686307784 0.337862688963278 no 2241 0.358843537067541 3123 1270615
SGTC_2966 9084041 48.03 µM -0.364179283257949 0.336869693063531 no 2242 0.357862067961159 2958 17741380
SGTC_2178 5812956 200 µM -0.364463386346017 0.336762395517609 no 2243 0.357756004924285 2994 5403383
SGTC_1092 toremifene 6.32 µM -0.365604714438018 0.336331482766389 no 2244 0.357330028353299 3024 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2710 st078562 53.7235 µM -0.366002085883437 0.336181504079845 no 2245 0.357181759549045 3009 17250908
SGTC_1331 1472-0049 76.2 µM -0.367661222307989 0.335555583215448 no 2246 0.356562929203944 3004 24051409
SGTC_665 3914-0008 307 µM -0.368648345599554 0.335183400287623 no 2247 0.35619492755966 3038 1069549
SGTC_306 1672-3436 11.6 µM -0.36992711250937 0.334701497168121 no 2248 0.355718399677719 3158 6797378
SGTC_3077 9117319 49.47 µM -0.370747243000806 0.334392574292181 no 2249 0.355412899581523 3070 17154678
SGTC_369 0957-0393 4.5 µM -0.371273107576149 0.334194553085561 no 2250 0.355217062930218 3093 6997992
SGTC_2433 5607874 27.82 µM -0.371989860559906 0.33392472465415 no 2251 0.354950199311649 3047 2252428
SGTC_3325 9138760 55.175 µM -0.372691894948492 0.333660520386345 no 2252 0.354688884730344 3072 43844959
SGTC_2004 4023728 41.89 µM -0.373288689353787 0.333435987071245 no 2253 0.354466796830369 3224 360084 YDR527W RBA50
SGTC_564 3555-0129 330 µM -0.373614536851073 0.333313417902507 no 2254 0.354345558548411 3103 563260
SGTC_1302 1159-0335 255 µM -0.37475784442261 0.332883497877797 no 2255 0.353920284199981 3058 649284
SGTC_1056 3448-1962 115 µM -0.380233533136879 0.330827517522915 no 2256 0.351886034692758 3148 715507
SGTC_2450 5739737 12.93 µM -0.381987499376998 0.330170022147426 no 2257 0.351235318448931 3166 2262825
SGTC_480 am 92016 50 µM -0.38225941297205 0.330068138934348 no 2258 0.351134478293179 3148 2129 K+ channel blocker.
SGTC_1115 galangin 695.678 nM -0.382869612432304 0.329839549382975 no 2259 0.350908221741897 3240 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2258 7960471 200 µM -0.382893534517306 0.329830589117318 no 2260 0.350899352720986 3143 2974708
SGTC_1876 myriocin 605 nM -0.383079915530041 0.329760781515684 no 2261 0.350830255460535 3251 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1836 st055642 81 µM -0.383543647338358 0.329587120001872 no 2262 0.350658357012498 3097 8571
SGTC_2981 9013952 38.96 µM -0.384600336762033 0.329191540887668 no 2263 0.350266772291057 3116 2996344
SGTC_2334 9017922 200 µM -0.385345917231713 0.328912542589808 no 2264 0.3499905730863 3195 3163164
SGTC_302 1094-0063 18.9 µM -0.385948598299734 0.32868708728983 no 2265 0.349767368741057 3064 5440289
SGTC_3129 9127257 49.47 µM -0.38657912099501 0.328451283516236 no 2266 0.349533908749864 3075 837894
SGTC_1721 st082152 9.2685 µM -0.387798819672586 0.32799533282029 no 2267 0.349082459534662 3062 5296051
SGTC_1270 0831-1170 17.3 µM -0.389003747064389 0.327545155521684 no 2268 0.348636687260617 3113 6764716
SGTC_482 fipronil 114 µM -0.389368977515345 0.327408749911373 no 2269 0.348501608640979 3152 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_3298 9116858 71.43 µM -0.390615568024058 0.326943349148753 no 2270 0.348040708255499 3222 2506942
SGTC_870 0573-2213 57.6 µM -0.392103304658269 0.326388271315569 no 2271 0.347490942938346 3146 3916321
SGTC_1032 k061-1018 98.7 µM -0.395686729524442 0.325052866824189 no 2272 0.346168073251371 3287 4005393
SGTC_1947 st076332 61.6 µM -0.39575391224246 0.325027851792632 no 2273 0.346143289698993 3221 24208416
SGTC_3148 9097893 49.47 µM -0.396019150219093 0.324929099927193 no 2274 0.346045450447645 3070 17174100
SGTC_1200 1643-0193 18.4 µM -0.396260129117998 0.324839390724424 no 2275 0.345956568635754 3214 5403974
SGTC_749 1000-0129 128 µM -0.397864384849151 0.324242433619653 no 2276 0.345365077103492 3270 708470
SGTC_357 1325-0123 420 µM -0.398759625931122 0.323909503028477 no 2277 0.345035164342391 3215 1098503
SGTC_1478 0453-0656 35.7 µM -0.399277581576718 0.323716945147394 no 2278 0.344844341943514 3189 5258496
SGTC_2324 6149169 200 µM -0.399455200012804 0.323650923656304 no 2279 0.344778913810092 3150 2888231
SGTC_2762 leflunomide 42.06 µM -0.3998715115902 0.323496200710744 no 2280 0.344625578050245 3094 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_272 doxorubicin 8.13 µM -0.400924446241998 0.323105011881553 no 2281 0.344237875427947 3165 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1232 0279-0259 161 µM -0.401109539707996 0.323036265707392 no 2282 0.344169738790018 3145 1560000
SGTC_3152 9099253 49.47 µM -0.40138824862397 0.32293276091463 no 2283 0.344067149960592 3145 25236131
SGTC_2168 5727979 200 µM -0.402505202545509 0.322518092739415 no 2284 0.343656130162308 3133 695210
SGTC_1096 rimcazole 32.2 µM -0.403468277799663 0.322160729027834 no 2285 0.343301883366924 3099 18528119 A dopamine reuptake inhibitor.
SGTC_12 0849-0099 9.267 µM -0.403938664683084 0.321986244540191 no 2286 0.343128911541045 3190 6071388
SGTC_121 0557-0495 61.343 µM -0.404242603007469 0.321873523053768 no 2287 0.343017164065402 3146 3104427
SGTC_1315 1237-0019 3.69 µM -0.405592474690281 0.32137309483078 no 2288 0.342521029538357 3242 825140
SGTC_635 k038-0028 24.7 µM -0.406049832227648 0.321203615416431 no 2289 0.342352992991307 3144 4035102
SGTC_890 0929-0006 47.2 µM -0.408325184889523 0.320361009642405 no 2290 0.341517475912823 3116 1378169
SGTC_938 3126-1755 342 µM -0.41045830475309 0.319571915429698 no 2291 0.340734891791178 3290 1777771
SGTC_2624 nerol 100 µM -0.411563687978471 0.319163327437154 no 2292 0.340329625739545 3113 637566 A natural product oil.
SGTC_1328 1441-0025 69.2 µM -0.411867979878437 0.319050889113797 no 2293 0.340218095703342 3103 4562601
SGTC_175 3793-3120 23.7 µM -0.41193885999814 0.319024700725121 no 2294 0.340192118502879 3106 5322297
SGTC_466 geldanamycin 89.2 µM -0.414558747137674 0.318057354208729 no 2295 0.339232476345606 3149 5288382 HSP90 inhibitor.
SGTC_91 0417-1751 58.384 µM -0.418036169535606 0.316775293727742 no 2296 0.337960336255679 3229 6795624
SGTC_2146 5545642 200 µM -0.419926297712694 0.316079359609342 no 2297 0.337269647959334 3227 825326
SGTC_1298 1079-1278 263 µM -0.419982404456292 0.316058711375185 no 2298 0.337249153867318 3200 2840950
SGTC_3249 9135183 49.47 µM -0.421627268674247 0.315453628612735 no 2299 0.336648549674663 3281 4902779
SGTC_2066 5222451 176 µM -0.421659036556637 0.315441947284165 no 2300 0.336636954073868 3138 2281147
SGTC_1438 4092-1045 4 µM -0.422000167192748 0.31531652218842 no 2301 0.336512447706599 3157 1351342
SGTC_439 amiodarone 34.4 µM -0.423056436163462 0.314928293852984 no 2302 0.336127042800921 3140 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1920 st075728 45.7 µM -0.424512491948834 0.314393460269062 no 2303 0.335596048493611 3305 3400306
SGTC_1843 st055809 45.5 µM -0.425143131640671 0.314161936557585 no 2304 0.335366168637783 3262 16413835
SGTC_557 1315-0110 16.2 µM -0.42532677449906 0.314094530380388 no 2305 0.335299238994498 3122 6833801
SGTC_2962 9082311 13.18 µM -0.425918038655282 0.313877548791981 no 2306 0.335083785061055 3105 16459453
SGTC_1683 st010134 710 nM -0.426054741635009 0.313827390811141 no 2307 0.335033978844587 3111 3818134
SGTC_3020 9089140 49.47 µM -0.426489083557732 0.313668048327042 no 2308 0.334875750429697 3264 17217859
SGTC_3076 9116187 49.47 µM -0.428785692861297 0.312826093564346 no 2309 0.33403959583517 3235 27241210
SGTC_1045 1348-1485 165 µM -0.429546630990025 0.312547342680934 no 2310 0.333762733138943 3161 6810614
SGTC_1581 himbacine 57.9 µM -0.429717815144675 0.312484648361317 no 2311 0.333700461290856 3152 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2987 9018338 71.43 µM -0.430321803175382 0.312263487730223 no 2312 0.33348078450359 3294 5055682
SGTC_1397 3532-0190 20.1 µM -0.430371348272043 0.312245348939034 no 2313 0.333462766964497 3071 5322280
SGTC_2482 5981709 142.65 µM -0.432600607497721 0.311429673659554 no 2314 0.332652474015914 3185 877755
SGTC_2238 6671620 73.2395 µM -0.433567344368374 0.311076236486851 no 2315 0.332301326320528 3110 729941
SGTC_219 mitoxanthrone 164.414 µM -0.435248843120426 0.31046189875063 no 2316 0.331690906491784 3191 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1863 st057641 20.1 µM -0.435272175084721 0.310453378099947 no 2317 0.331682439630343 3241 3921635
SGTC_1198 1612-1005 86.7 µM -0.43684709805815 0.309878463900352 no 2318 0.331111119886817 3343 6998509
SGTC_975 1335-0046 28.5 µM -0.437093080540159 0.309788711698894 no 2319 0.331021922623632 3185 16486740
SGTC_1216 1165-0504 9.65 µM -0.437464356210327 0.309653264951868 no 2320 0.330887310167289 3292 6304004
SGTC_1191 1487-1166 10.6 µM -0.438012319077741 0.309453407376698 no 2321 0.330688676640103 3263 3955771
SGTC_124 0136-0217 7.121 µM -0.438063321990049 0.309434808035695 no 2322 0.330670190788971 3355 3976905
SGTC_1628 st004252 77.7 µM -0.438183866672274 0.309390850689265 no 2323 0.330626501375618 3284 692968
SGTC_2790 5423970 71.43 µM -0.438528285004366 0.309265271494942 no 2324 0.330501685402384 3312 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2338 7999974 200 µM -0.439417587647713 0.308941123774334 no 2325 0.330179492503972 3182 315925
SGTC_1716 st033144 30.6155 µM -0.439428408113863 0.308937180667451 no 2326 0.330175573041437 3337 674617
SGTC_2469 5655019 90.81 µM -0.442278600399049 0.307899304504945 no 2327 0.329143807194842 3300 2788239
SGTC_71 0417-1750 47.813 µM -0.44259242306359 0.307785121990361 no 2328 0.329030283119017 3321 6811472
SGTC_35 0133-0054 64.071 µM -0.442893646121768 0.307675541273842 no 2329 0.328921331729635 3204 99677
SGTC_2300 7976697 71.57 µM -0.444047911560798 0.307255794615665 no 2330 0.32850397234117 3125 2236109
SGTC_133 0724-0033 378.92 µM -0.444654247038743 0.307035402822489 no 2331 0.328284819160478 3095 280309
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.445711787733254 0.30665117306791 no 2332 0.327902724315935 3165 442882
SGTC_2774 tamoxifen 10.92 µM -0.445869763077561 0.306593795081037 no 2333 0.327845662468039 3275 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_3095 9117207 49.47 µM -0.446457407174317 0.306380399373732 no 2334 0.327633436420214 3253 17015229
SGTC_114 0364-0001 490.298 µM -0.448264792527103 0.305724481382673 no 2335 0.326981053360369 3261 4003655
SGTC_293 4049-0273 38.5 µM -0.448292058139131 0.305714591186412 no 2336 0.326971215768337 3210 1380311
SGTC_1559 coumarin 343 70.1 µM -0.449969290145526 0.305106472881785 no 2337 0.326366292094972 3336 108770 A hepatotoxic, DNA x-linker.
SGTC_44 0929-0055 61.211 µM -0.450395961942315 0.304951859122319 no 2338 0.326212478052825 3148 1379590
SGTC_2505 galangin 7.89 µM -0.450992076510954 0.304735902411458 no 2339 0.325997629841843 3111 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1193 1488-0126 41.5 µM -0.451217238008862 0.304654349986602 no 2340 0.325916493443191 3207 1384710
SGTC_332 4112-0506 40.9 µM -0.451256518127698 0.304640123908529 no 2341 0.325902339792141 3199 2790355
SGTC_2620 irigenin 100 µM -0.451336032100772 0.304611327242482 no 2342 0.325873689602259 3354 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1038 k292-0204 154 µM -0.454706461822498 0.303391812499435 no 2343 0.324660215729329 3130 4454212
SGTC_859 0439-0102 54.6 µM -0.458844398911526 0.30189758341599 no 2344 0.323172954419927 3330 610143
SGTC_878 0828-0289 13.7 µM -0.460584427053658 0.301270239957111 no 2345 0.32254839325796 3229 745350 YLR208W SEC13
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.462062898326396 0.300737659093248 no 2346 0.3220181077566 3203 16623 A steroid.
SGTC_2089 5281248 129.67 µM -0.462467990001701 0.30059180952487 no 2347 0.321872876086644 3254 2737878
SGTC_1201 1889-3372 45.9 µM -0.462519296153576 0.300573339490853 no 2348 0.321854483973369 3190 5392199
SGTC_3159 9100096 49.47 µM -0.463795606702121 0.300114037217876 no 2349 0.321397095623024 3193 25236875
SGTC_3039 9090270 49.47 µM -0.464133396419248 0.299992530930671 no 2350 0.321276088005676 3354 17173750
SGTC_303 1348-1668 34.2 µM -0.469021970357332 0.298236560829117 no 2351 0.319526965996065 3264 5380509
SGTC_84 0443-0269 128.823 µM -0.470532685956036 0.297694861778956 no 2352 0.318987243696272 3328 6150058
SGTC_922 1866-0035 480 µM -0.47071425755083 0.29762978567305 no 2353 0.318922400740773 3207 3156169
SGTC_2459 5811157 9.22 µM -0.47109767856103 0.297492387130479 no 2354 0.318785491411657 3309 2870684 YBR192W RIM2
SGTC_2855 9016525 58.44 µM -0.472114393668349 0.297128188569536 no 2355 0.318422569557605 3253 43811474
SGTC_524 r073-0010 27.8 µM -0.472171036617003 0.29710790443696 no 2356 0.318402355675475 3180 2772106
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.472340073967936 0.29704737505271 no 2357 0.31834203538658 3392 688751
SGTC_931 2812-0076 566 µM -0.474263022538897 0.29635919742323 no 2358 0.317656178373327 3221 3450959
SGTC_1076 itraconazole 331 nM -0.474535664056778 0.296261684692731 no 2359 0.317558986032828 3302 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2841 9004761 38.96 µM -0.474860453385357 0.296145540031307 no 2360 0.317443220243528 3236 2991039
SGTC_1430 4049-0248 69.1 µM -0.474942351917548 0.296116256415302 no 2361 0.317414031683163 3327 22774488
SGTC_593 1203-0218 61.7 µM -0.475153612640134 0.296040724226199 no 2362 0.317338743800927 3365 3666956
SGTC_3280 9140961 49.47 µM -0.475833552588111 0.29579768489022 no 2363 0.31709648202486 3207 4901226
SGTC_2331 7980721 200 µM -0.478064311982302 0.295000961412886 no 2364 0.316302215954272 3255 2981221
SGTC_864 0469-0573 172 µM -0.47959260462796 0.29445569769574 no 2365 0.315758552981802 3258 689425
SGTC_184 1494-0393 24.714 µM -0.479660781749106 0.294431384329148 no 2366 0.315734309455485 3188 3090647
SGTC_1502 4534-4282 27.7 µM -0.480793718740894 0.294027491375919 no 2367 0.315331557463762 3272 3278949
SGTC_3213 9129884 49.47 µM -0.481132968280586 0.293906598490907 no 2368 0.315210999033231 3297 17190742
SGTC_1113 artemisinin 1.17947 µM -0.48176454243395 0.293681595857193 no 2369 0.314986610210893 3337 2240 An anti-malaria and mitochondrial poison.
SGTC_2534 helenine 20.12 µM -0.48182973885225 0.293658373725567 no 2370 0.314963450787455 3261 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2865 9030313 51.95 µM -0.482641980553644 0.293369134888038 no 2371 0.314674982923053 3190 42562754
SGTC_3353 9151644 39.2805 µM -0.483028215640688 0.29323164310432 no 2372 0.314537851080985 3356 4909158
SGTC_1453 4237-0541 195 µM -0.486384085169377 0.29203828158299 no 2373 0.313347436073043 3351 739892
SGTC_1334 1486-0610 236 µM -0.489020423105431 0.291102377231563 no 2374 0.312413618977877 3341 3742339
SGTC_493 zm226600 134 µM -0.489169919548952 0.291049347741209 no 2375 0.312360701852047 3408 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2032 5185112 25.99 µM -0.489856563950805 0.290805838706551 no 2376 0.312117700649268 3270 5718189
SGTC_2667 digitoxin 100 µM -0.490685503339539 0.290511993671998 no 2377 0.311824450604386 3335 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3184 9108758 49.47 µM -0.491130226030807 0.290354404271337 no 2378 0.311667172262019 3291 902885
SGTC_56 0957-0365 83.25 µM -0.491132879744991 0.290353464036441 no 2379 0.311666233866163 3348 6752360
SGTC_435 c-PAF 6.7 µM -0.493921993667376 0.28936604494072 no 2380 0.310680635616203 3336 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1743 st037606 46.3785 µM -0.495792750704257 0.288704633417025 no 2381 0.310020320012759 3270 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2782 7736369 71.43 µM -0.496105608491339 0.288594091172045 no 2382 0.309909951221913 3285 2950836 YOL077C BRX1
SGTC_485 niflumic acid 177 µM -0.496602167753643 0.288418682515574 no 2383 0.309734812088797 3377 4488 A COX2 inhibitor.
SGTC_1381 2324-0066 62.1 µM -0.498238721692178 0.287840928859012 no 2384 0.309157896543888 3330 10885928
SGTC_1968 st069590 43.6 µM -0.49840128968607 0.287783567238242 no 2385 0.309100613973821 3343 6384066
SGTC_2736 butenafine 14.65 µM -0.49850370934956 0.28774743154535 no 2386 0.309064527693746 3273 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1403 3909-7815 62.9 µM -0.498992692925403 0.287574937977539 no 2387 0.308892265882671 3265 6615483
SGTC_1534 6-azauridine 81.6 µM -0.499304948830409 0.287464812342964 no 2388 0.308782284648694 3282 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1436 4092-1007 8.32 µM -0.499341015257251 0.287452093810329 no 2389 0.308769582614228 3280 2881121
SGTC_2669 eugenol 100 µM -0.501153329694968 0.286813338772177 no 2390 0.308131608474169 3326 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1779 st039427 55 µM -0.501346375949124 0.286745338772651 no 2391 0.308063686094538 3441 1124498
SGTC_909 3448-9333 149 µM -0.5038948264488 0.28584837147745 no 2392 0.307167643154076 3272 3344074
SGTC_2944 9067346 25.62 µM -0.504364477167451 0.285683216215225 no 2393 0.307002637890533 3383 6473075
SGTC_2735 sertaconazole 140 nM -0.504689249922765 0.285569034645291 no 2394 0.30688855634449 3364 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_3185 9108267 49.47 µM -0.50495104368685 0.285477010648238 no 2395 0.306796610771122 3366 4910486
SGTC_1020 4335-0961 93.3 µM -0.505148958596841 0.285407450292384 no 2396 0.306727108397518 3204 669075
SGTC_2127 5253358 187.912 µM -0.508329581719581 0.28429067814974 no 2397 0.305611113895208 3247 20612
SGTC_967 1306-0166 352 µM -0.508882218526605 0.284096850944525 no 2398 0.305417392214433 3393 4437607
SGTC_3206 9114350 49.47 µM -0.510762956633349 0.283437690621428 no 2399 0.304758525400321 3346 17087243
SGTC_2627 acetyl isogambogic acid 100 µM -0.511673586595035 0.283118797036261 no 2400 0.304439737495575 3358 6857789 A caspase activator and apoptosis inducer.
SGTC_661 1304-0007 33.6 µM -0.511949947377958 0.283022052294191 no 2401 0.304343020125132 3317 3117130
SGTC_1668 st014914 51.6 µM -0.513353288219809 0.282531034253997 no 2402 0.303852107306041 3400 2839556
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.514285790843171 0.282204985505446 no 2403 0.303526097276845 3360 91467 include heat shock
SGTC_731 3966-0296 387 µM -0.515836254368218 0.281663268484661 no 2404 0.302984389511162 3345 660956
SGTC_2077 5212015 200 µM -0.51782344404293 0.280969697543325 no 2405 0.302290729810403 3319 780900
SGTC_1249 0481-0015 10.2 µM -0.519972112338154 0.280220697095625 no 2406 0.301541506258785 3286 4227577
SGTC_3285 9112818 20.8695 µM -0.52006586206385 0.280188039081469 no 2407 0.301508835503893 3384 17017947 YPR165W RHO1
SGTC_82 0054-0107 293.755 µM -0.520285850463975 0.280111412666261 no 2408 0.30143217820512 3358 3104697
SGTC_718 1130-0073 349 µM -0.521724586610924 0.279610522285228 no 2409 0.300931051729013 3485 6740020
SGTC_1498 4478-3555 97.6 µM -0.523473003648358 0.279002403546621 no 2410 0.30032256644299 3396 3437919
SGTC_1728 st035614 33.7865 µM -0.524030225823063 0.278808730788843 no 2411 0.300128758512771 3342 15945546
SGTC_227 fluconazole 33.516 µM -0.52420809956347 0.278746921296747 no 2412 0.300066904004131 3363 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1860 st056228 74.6 µM -0.524421558625651 0.278672755038343 no 2413 0.299992682530268 3382 688679
SGTC_1935 st074532 41.6 µM -0.525034976682555 0.27845967669462 no 2414 0.299779438270822 3400 2829742
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.52521228798729 0.278398100213735 no 2415 0.299717811829371 3359 6708739 YPR165W RHO1
SGTC_2862 9027634 71.43 µM -0.526626418071769 0.277907240265804 no 2416 0.299226521299514 3274 5012562
SGTC_93 0109-0045 59.227 µM -0.527180650348749 0.277714975499144 no 2417 0.299034072207483 3444 88733
SGTC_714 4296-0578 26.1 µM -0.52782609427962 0.277491151061209 no 2418 0.298810022060931 3339 1589775
SGTC_2589 lobaric acid 100 µM -0.528359358590659 0.277306294355978 no 2419 0.298624969908797 3321 73157 A novel microtubule depolymerizer.
SGTC_3 0833-0587 95.581 µM -0.528953747134356 0.277100319862723 no 2420 0.29841876800584 3365 5382644
SGTC_2356 9061756 188.97 µM -0.529108944515312 0.277046551374041 no 2421 0.298364938480436 3358 20104043
SGTC_90 0870-0863 4.608 µM -0.530021177250303 0.276730609512134 no 2422 0.29804862396697 3354 1738164
SGTC_2520 obtusaquinone 4.71 µM -0.530676412570045 0.276503784889853 no 2423 0.297821517035638 3490 5967872
SGTC_2476 5806916 10.51 µM -0.532199007333732 0.275977056334143 no 2424 0.297294085209469 3318 2870194
SGTC_1135 dihydrocapsaicin 536.708 nM -0.533259494532003 0.275610481291219 no 2425 0.296926981311634 3367 107982 A Capsaicinoid.
SGTC_2121 5257820 149.641 µM -0.53393185042779 0.275378194369478 no 2426 0.296694342499191 3453 791256
SGTC_1252 0493-0875 34.8 µM -0.535255412492466 0.274921209036174 no 2427 0.296236626842597 3333 3960963
SGTC_1037 k284-1091 78.7 µM -0.536122972399919 0.274621870134796 no 2428 0.295936782177964 3428 3334711
SGTC_1313 1220-0047 237 µM -0.539224700180495 0.27355298079768 no 2429 0.294865909492974 3385 3528706
SGTC_3302 9125395 16.351 µM -0.539385741871564 0.273497540345428 no 2430 0.294810358594644 3328 17599668
SGTC_1176 0848-0131 83.3 µM -0.539579180728404 0.273430954150106 no 2431 0.294743638759988 3408 6769040
SGTC_1694 st024011 44.9 µM -0.540482041802442 0.273120274369493 no 2432 0.294432321162645 3458 2787533
SGTC_3197 9113331 49.47 µM -0.540595244509312 0.273081333001297 no 2433 0.29439329818934 3497 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1358 1509-0022 2.48 µM -0.542587904713059 0.272396315182422 no 2434 0.2937067843091 3416 3258434
SGTC_2103 5378138 10 µM -0.542924479633086 0.272280694963399 no 2435 0.293590900262761 3480 244142
SGTC_2400 5203494 178.7 µM -0.544378105175143 0.271781625758732 no 2436 0.293090654686974 3423 6777674
SGTC_1412 3909-8563 178 µM -0.547656451345748 0.270657754019692 no 2437 0.29196390985336 3491 23767530
SGTC_2595 hexamethylquercetagetin 100 µM -0.54814680678999 0.27048985174955 no 2438 0.291795551647587 3361 386331
SGTC_1560 lithocholic acid 53.1 µM -0.548149090760625 0.270489069818522 no 2439 0.291794767576966 3403 9903 A bile acid which acts as a detergent.
SGTC_2208 7283366 200 µM -0.54836701355304 0.270414467840475 no 2440 0.291719960771997 3442 898663
SGTC_2118 5526350 200 µM -0.550933999754426 0.269536480651506 no 2441 0.290839459615911 3411 743594
SGTC_3268 9137683 49.47 µM -0.551144548078434 0.269464530176473 no 2442 0.290767294662421 3370 1953228
SGTC_2483 5729050 27.16 µM -0.551172085928128 0.269455120405703 no 2443 0.290757856746993 3498 2865180
SGTC_3048 9093155 49.47 µM -0.552561435042358 0.268980589284623 no 2444 0.290281877809871 3444 25236002
SGTC_2882 9058044 58.44 µM -0.553097911854003 0.268797468373904 no 2445 0.290098183232262 3409 18076804
SGTC_2634 4'-methoxyflavone 100 µM -0.554935352781077 0.268170751451921 no 2446 0.289469439824368 3386 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_852 0418-0143 439 µM -0.55583444565683 0.267864355758174 no 2447 0.289162017765025 3470 5369229
SGTC_45 0kpi-0036 14.9 µM -0.556381384283954 0.267678054592911 no 2448 0.288975081066549 3458 2795021
SGTC_2408 sulbentine 18.36 µM -0.557988937677468 0.267130859453864 no 2449 0.288425969075576 3313 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_540 1187-0821 17.3 µM -0.55802120238659 0.267119882652163 no 2450 0.28841495305451 3365 847520
SGTC_2249 haloperidol 116.36 µM -0.558435477866844 0.266978961905479 no 2451 0.288273526124815 3448 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2584 androsterone 48.74 µM -0.559843102168324 0.26650042241261 no 2452 0.287793230544355 3491 2754130 A steroid.
SGTC_1159 4092-0538 61.2 µM -0.560685365454357 0.266214292076744 no 2453 0.287506022715144 3469 717301
SGTC_2659 sanguinarine 24.21 µM -0.561029269689752 0.266097507026474 no 2454 0.287388791963213 3385 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2466 5983409 37.09 µM -0.562388791976502 0.265636086496705 no 2455 0.286925576849934 3391 2879657
SGTC_2958 9077254 16.72 µM -0.564818890674837 0.26481232544294 no 2456 0.286098478339267 3520 16457351
SGTC_113 0099-0221 2.5 µM -0.565653802076503 0.264529605088195 no 2457 0.285814572964037 3527 89219
SGTC_2691 st077356 60.2 µM -0.566445926327428 0.264261515501222 no 2458 0.285545340957252 3515 2839272
SGTC_636 0kpi-0074 126 µM -0.567218977237207 0.264000014630909 no 2459 0.285282708161651 3438 616434
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.567989758572153 0.263739412848569 no 2460 0.285020961050803 3454 688662
SGTC_1064 honokiol 6.76 µM -0.568956653154002 0.263412690641554 no 2461 0.284692778496557 3434 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2845 9003024 42.97 µM -0.569544054075394 0.263214303632352 no 2462 0.284493491483584 3550 2990173
SGTC_1617 st002906 78 µM -0.571603383789514 0.262519395177754 no 2463 0.283795351249794 3497 5150859
SGTC_1395 3486-0190 4.35 µM -0.571754671258234 0.262468381182849 no 2464 0.283744095141138 3527 6748079
SGTC_2424 5537928 59.2 µM -0.572340608952637 0.262270851435293 no 2465 0.283545621625991 3427 5382802
SGTC_2598 perillyl alcohol 100 µM -0.572682376347094 0.262155670897977 no 2466 0.283429886158827 3492 10819 An apoptosis inducer.
SGTC_1409 3909-8004 61.9 µM -0.576326899513742 0.260929028076408 no 2467 0.282197122106848 3450 2119279
SGTC_2560 caryophyllene 100 µM -0.578253208329375 0.260281881760991 no 2468 0.281546590177901 3445 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_3121 9125696 49.47 µM -0.579496054579687 0.25986478506685 no 2469 0.281127254015161 3515 1235365
SGTC_411 enrofloxacin 100 µM -0.579542824302401 0.259849095976983 no 2470 0.28111147980845 3558 71188 A bacterial gyrase inhibitor.
SGTC_2161 5662504 8.5105 µM -0.580436210354151 0.259549499914869 no 2471 0.280810246124894 3439 2859334
SGTC_2414 st077232 92.9 µM -0.58080128970634 0.259427122299217 no 2472 0.280687192882109 3334 729801
SGTC_973 1325-0077 65.9 µM -0.581740438852085 0.25911244875594 no 2473 0.280370764215289 3481 2835149
SGTC_3242 9133940 49.47 µM -0.583113709379595 0.258652672981314 no 2474 0.279908377685074 3539 17248444
SGTC_1913 st060213 96.1 µM -0.583755432992378 0.258437966565217 no 2475 0.279692433233201 3535 688959
SGTC_1106 tegaserod maleate 11.7 µM -0.584753612355963 0.258104181594473 no 2476 0.279356699713551 3452 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2114 5491910 81.25 µM -0.587396088878888 0.257221634303169 no 2477 0.278468859982362 3532 2849228
SGTC_2332 7982454 138.89 µM -0.587493944425758 0.257188982176934 no 2478 0.278436008133593 3494 2981748
SGTC_1379 2144-0755 36.5 µM -0.588523839677293 0.256845460758633 no 2479 0.278090368542535 3560 5392327
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.593180173223289 0.255295326908381 no 2480 0.276530289984407 3466 115019
SGTC_2677 mitomycin C 100 µM -0.593574469221522 0.25516428731486 no 2481 0.276398380622869 3500 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_311 1315-0136 58 µM -0.595096658140236 0.254658736098463 no 2482 0.275889431183043 3557 6759207
SGTC_1466 k213-0079 57.5 µM -0.596294215725695 0.254261370830005 no 2483 0.275489347266026 3488 3657981
SGTC_3017 9080681 49.47 µM -0.596496548220289 0.254194266379094 no 2484 0.27542177956341 3489 16451914
SGTC_705 1124-0212 310 µM -0.596861096127023 0.254073385926681 no 2485 0.275300061595635 3525 9554485
SGTC_1048 3161-0300 24.5 µM -0.597554205840033 0.253843640850847 no 2486 0.275068714012753 3528 2165101
SGTC_526 4469-0568 170 µM -0.598481897260277 0.253536309720446 no 2487 0.274759217196611 3530 2901964
SGTC_575 k072-0246 11.9 µM -0.598969929743278 0.25337470992382 no 2488 0.274596468533311 3524 6796779
SGTC_373 0844-0104 25.9 µM -0.602797724364046 0.252109111083021 no 2489 0.273321630407719 3533 5375804
SGTC_2645 abamectin 100 µM -0.602880732611428 0.252081702727975 no 2490 0.27329401720914 3521 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1118 chelidonine 707.474 nM -0.603756580618509 0.251792603754866 no 2491 0.273002745274608 3545 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1523 st012844 44.7 µM -0.605138972384234 0.251336661791904 no 2492 0.272543330568853 3518 4274103
SGTC_1895 st058434 18.3 µM -0.606086239492479 0.251024485313642 no 2493 0.272228744018044 3562 5393175
SGTC_2413 inermin 26.06 µM -0.607894730078899 0.250429058665424 no 2494 0.271628647501846 3608 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1242 0402-0103 60.1 µM -0.608260849729684 0.250308608764753 no 2495 0.271507241252007 3501 432868
SGTC_609 0986-0026 86.3 µM -0.609164506614099 0.250011445712861 no 2496 0.271207701954656 3521 2848610
SGTC_2948 9070189 9.45 µM -0.609236092276945 0.249987913129808 no 2497 0.27118398017074 3487 6473636 YDL196W YDL196W
SGTC_2684 capsaicin 100 µM -0.610480473816728 0.24957903149426 no 2498 0.270771787126393 3545 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3168 9103419 49.47 µM -0.611121358182988 0.249368586986312 no 2499 0.270559620567498 3500 16649256
SGTC_2507 purpurin 79.67 µM -0.612003112465223 0.249079203269381 no 2500 0.270267849147263 3439 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2654 protoveratrine a 100 µM -0.612053784306159 0.249062578663198 no 2501 0.270251086678139 3509 5702278 A heart drug and vasodilator.
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.61252033640106 0.248909538259377 no 2502 0.270096773613702 3504 6708561
SGTC_1219 1469-0211 33.1 µM -0.613320555495915 0.248647163574608 no 2503 0.26983220218349 3524 6822282
SGTC_2011 4012611 177 µM -0.614341155456139 0.248312744595749 no 2504 0.26949495598942 3526 2049887
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.614368840449274 0.248303676423126 no 2505 0.269485810727362 3523 688761
SGTC_869 0564-0080 44.1 µM -0.615182180738178 0.248037346991651 no 2506 0.269217207159562 3501 6843321
SGTC_1243 0416-0003 5.65 µM -0.61565193005506 0.247883596372142 no 2507 0.269062134842605 3491 2141977
SGTC_2934 9036370 36.88 µM -0.616615256398648 0.247568455431987 no 2508 0.268744264561954 3516 6462800
SGTC_225 nsc-122657 1.016 µM -0.617767896454449 0.247191664167391 no 2509 0.268364174206305 3504 275685
SGTC_3135 9127742 49.47 µM -0.618109116264022 0.247080180275246 no 2510 0.268251706701084 3494 3643468
SGTC_2295 7971645 200 µM -0.618492839659675 0.246954841679884 no 2511 0.268125258166704 3511 2978226 YKL099C UTP11
SGTC_594 1487-1584 10.8 µM -0.618725951340968 0.246878715191577 no 2512 0.268048455425607 3485 5013332
SGTC_2131 toluylene red 5.2905 µM -0.618892401428058 0.246824365840299 no 2513 0.267993622296615 3515 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1283 0922-0125 16.4 µM -0.621331241675198 0.246028769674708 no 2514 0.267190850989401 3525 3360884
SGTC_765 1319-0117 244 µM -0.62234045124497 0.245699949180491 no 2515 0.266859013874735 3553 3487746 YGL099W LSG1
SGTC_1279 0874-0590 65.2 µM -0.623060585742419 0.245465459428287 no 2516 0.266622354591737 3523 3523074
SGTC_3273 9137859 49.47 µM -0.62336441582235 0.245366562544818 no 2517 0.266522538126563 3600 2377234
SGTC_419 nsc-638432 893 µM -0.625210548049877 0.244766105990185 no 2518 0.265916439943142 3519 368090
SGTC_3119 9125183 49.47 µM -0.625512032083038 0.244668123167732 no 2519 0.265817526995191 3417 22695334
SGTC_3266 9136860 49.47 µM -0.62555969636383 0.244652634129383 no 2520 0.265801890678603 3493 4871271 YPR165W RHO1
SGTC_469 w7 172 µM -0.627178520521302 0.24412689285018 no 2521 0.265271110687292 3573 45115570 A P450 inhibitor.
SGTC_1205 4161-2785 76 µM -0.627209225683125 0.244116926706314 no 2522 0.265261048282636 3517 3498106
SGTC_611 3453-1652 23.7 µM -0.62772333912942 0.243950090664085 no 2523 0.265092596686358 3574 1560575
SGTC_2173 5763948 167 µM -0.630270651427353 0.243124365236581 no 2524 0.264258760657576 3567 2867177
SGTC_1341 1486-1360 280 µM -0.631492441124575 0.242728852257907 no 2525 0.263859295041401 3553 3976547
SGTC_3179 9107801 49.47 µM -0.632004524874313 0.242563186149278 no 2526 0.263691960245285 3553 4818259
SGTC_1771 st048882 4.1505 µM -0.63569149287152 0.241372211074751 no 2527 0.262488761155054 3471 4580403
SGTC_651 3253-0966 34.4 µM -0.635900418734421 0.241304818482002 no 2528 0.262420664868451 3558 781462
SGTC_58 0957-0393 9 µM -0.63805198634025 0.240611388919327 no 2529 0.261719919917154 3554 6997992
SGTC_1571 st070080 73.4 µM -0.640984999771189 0.239667856853187 no 2530 0.260766214390348 3623 4315245
SGTC_3021 9087658 49.47 µM -0.641485932128918 0.239506912178646 no 2531 0.260603509010995 3587 25237042
SGTC_3223 9129970 49.47 µM -0.641607997979489 0.239467702556608 no 2532 0.260563869321744 3620 17248386
SGTC_3208 9114115 49.47 µM -0.641701072369203 0.239437807839025 no 2533 0.260533646411379 3530 650895
SGTC_2064 5220758 200 µM -0.643228617163297 0.238947464512792 no 2534 0.260037883462399 3637 788518
SGTC_47 0149-0135 24.25 µM -0.645005290362267 0.238377842128958 no 2535 0.259461878676231 3503 5239155
SGTC_1415 3966-0071 78.1 µM -0.645735287540735 0.238144012143113 no 2536 0.259225401731492 3587 2893185
SGTC_2199 6590217 200 µM -0.648688116015271 0.237199456770726 no 2537 0.258269993652441 3542 703109
SGTC_1321 1326-2144 215 µM -0.649468858262776 0.236950056176684 no 2538 0.25801768451352 3566 3513030
SGTC_2665 lovastatin 100 µM -0.649766343226261 0.236855065408174 no 2539 0.257921581215706 3597 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1801 st050089 28.441 µM -0.649777276738349 0.236851574596331 no 2540 0.257918049469797 3611 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_10 0279-0212 42.575 µM -0.650056845515004 0.236762324507372 no 2541 0.257827751614941 3609 39851 YBR002C RER2
SGTC_1278 0874-0585 172 µM -0.650060620297071 0.236761119565048 no 2542 0.257826532511214 3583 766306
SGTC_1292 0kpi-0043 232 µM -0.650175017486459 0.236724604615652 no 2543 0.257789588210673 3566 3333905
SGTC_2407 paclitaxel 400 µM -0.653897153779185 0.235538210815841 no 2544 0.256589033892239 3626 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1901 st060216 58.6 µM -0.654456570335532 0.235360186370929 no 2545 0.256408849243241 3611 688792
SGTC_693 4161-2696 114 µM -0.654861274863791 0.235231442613021 no 2546 0.256278537506944 3604 805759
SGTC_2788 5282734 71.43 µM -0.657423180539612 0.234417357407071 no 2547 0.255454425324215 3634 743706
SGTC_2128 5255449 168.493 µM -0.657732124578969 0.234319291096089 no 2548 0.255355138047006 3609 736008
SGTC_712 r015-0009 80.6 µM -0.65922549316152 0.233845580081046 no 2549 0.254875489383845 3583 6813872 YLR060W FRS1
SGTC_3002 9075603 71.4286 µM -0.659589631193611 0.233730152492235 no 2550 0.254758604996731 3593 20105405
SGTC_991 3996-0057 64.7 µM -0.660149482775305 0.233552747570773 no 2551 0.254578953425566 3601 715343
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.660478819888561 0.23344842261955 no 2552 0.25447330297999 3571 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_3190 9110366 49.47 µM -0.660778991256713 0.233353359097354 no 2553 0.254377028841813 3547 17123768
SGTC_559 1550-0661 158 µM -0.661947822945336 0.232983397754844 no 2554 0.254002330744154 3626 5830875
SGTC_2726 cimetidine 79.27 µM -0.662292983929663 0.232874208927097 no 2555 0.253891736208762 3608 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_193 1273-0060 1.558 µM -0.663104505333981 0.232617602858324 no 2556 0.253631812697265 3522 2847393 YHR072W ERG7
SGTC_2186 6124449 200 µM -0.663111901460178 0.23261526489892 no 2557 0.253629444422842 3581 3834182 YLR033W RSC58
SGTC_2890 9046729 58.44 µM -0.663303083190376 0.232554835752007 no 2558 0.253568231163639 3545 903329
SGTC_1572 epiandrosterone 68.9 µM -0.663689137546604 0.232432837443584 no 2559 0.25344464654435 3581 441302 A steroid.
SGTC_1971 st069429 63.5 µM -0.663917831101834 0.232360584032115 no 2560 0.253371451563331 3607 1246522 YGL099W LSG1
SGTC_123 0083-0120 66.675 µM -0.665372667589512 0.231901235859572 no 2561 0.252906081205275 3566 16001701
SGTC_2907 7721985 69.9 µM -0.665594827319323 0.23183113597434 no 2562 0.252835056783725 3585 3267881
SGTC_739 1486-1183 203 µM -0.667215645757961 0.231320063165417 no 2563 0.252317199367565 3614 4346692
SGTC_831 k061-1017 217 µM -0.671541307588124 0.229959186546827 no 2564 0.250937876894637 3663 1240153
SGTC_176 1486-1328 72.834 µM -0.671896282424861 0.229847708843713 no 2565 0.250824863618622 3626 22310231
SGTC_1144 3486-0183 12.5 µM -0.672152999113925 0.229767107374336 no 2566 0.250743149564673 3643 6744069
SGTC_2104 5389443 200 µM -0.672819721170198 0.229557850260634 no 2567 0.250530994858169 3672 2244536
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.673185879265237 0.229442973467516 no 2568 0.250414521766564 3645 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1468 k284-1086 134 µM -0.673530751446054 0.229334804290734 no 2569 0.250304845871107 3652 15996457
SGTC_1865 st057639 52.2 µM -0.674138405809549 0.229144283048296 no 2570 0.250111662242922 3635 688818
SGTC_2060 5238662 140 µM -0.674338752325232 0.229081486758695 no 2571 0.250047986029262 3607 790130
SGTC_1088 bifonazole 369 nM -0.674490759476595 0.229033848323085 no 2572 0.249999679274407 3581 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_757 1066-0008 322 µM -0.675488312273412 0.228721357202727 no 2573 0.249682787254717 3640 6842497
SGTC_1700 st030840 7.9285 µM -0.675613294525203 0.228682222428754 no 2574 0.249643099259122 3646 5499307
SGTC_2038 4100038 30.985 µM -0.676863387360465 0.228290996992814 no 2575 0.249246317906334 3634 3596803
SGTC_1489 4065-0444 182 µM -0.677327639948916 0.228145801699559 no 2576 0.249099048873355 3621 2877968
SGTC_425 3825-7017 13.1 µM -0.677369205581757 0.228132804554398 no 2577 0.24908586578641 3683 3397440
SGTC_2298 7976326 193.81 µM -0.67742669352435 0.228114829353152 no 2578 0.24906763334126 3533 2235818
SGTC_1296 1068-0102 11.9 µM -0.67815597390262 0.227886868744099 no 2579 0.248836401887428 3613 767053
SGTC_1997 st073024 93.8 µM -0.678461197107551 0.227791499236796 no 2580 0.248739659318257 3640 686268
SGTC_2960 9079389 5.97 µM -0.684398866802106 0.225940699960645 no 2581 0.246861665695936 3626 16457355
SGTC_2952 9073731 13.78 µM -0.685161745737941 0.225703524963775 no 2582 0.246620930208058 3659 16457353
SGTC_887 0885-0007 9.62 µM -0.686586044990035 0.225261095099458 no 2583 0.24617181244104 3675 5719458
SGTC_1264 0783-0040 158 µM -0.690656006529868 0.223999554389686 no 2584 0.244890871145163 3607 2855798
SGTC_1632 st005650 90 µM -0.690696986562637 0.223986872508326 no 2585 0.244877991741789 3661 2759605
SGTC_368 fentichlor 4.58 µM -0.690740620287442 0.223973369850871 no 2586 0.244864278723933 3630 7329 A pesticide.
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.69348170230565 0.223126056974567 no 2587 0.244003652413198 3629 390807
SGTC_2427 5545055 42.75 µM -0.694002449107793 0.222965292246144 no 2588 0.243840336512489 3674 5372858
SGTC_965 1291-5240 308 µM -0.695074251686194 0.222634613545537 no 2589 0.24350438499893 3648 2834598
SGTC_1765 st044815 90.4 µM -0.695639473836328 0.222460340607354 no 2590 0.243327319499646 3667 645695
SGTC_46 0329-0187a 2.197 µM -0.696482195725014 0.222200651684468 no 2591 0.243063451729874 3683 46494817
SGTC_2244 6635614 200 µM -0.69653640614138 0.222183952400468 no 2592 0.243046483004982 3589 836499
SGTC_2 0422-0095 29 µM -0.696730413232898 0.222124195224609 no 2593 0.242985760940967 3566 6790840
SGTC_1809 st050081 57.6 µM -0.696793496918246 0.222104766453293 no 2594 0.242966018216551 3722 5036894
SGTC_1994 st072947 40.9 µM -0.697277966073628 0.221955589995953 no 2595 0.242814427259284 3683 5286565 YDL195W SEC31
SGTC_261 5-fluorouridine 15.376 µM -0.697586491484483 0.221860619495736 no 2596 0.242717915986599 3700 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.69862439704762 0.22154130112586 no 2597 0.24239339639207 3682 688664
SGTC_410 α-linolenic acid 100 µM -0.698718857022634 0.221512252950296 no 2598 0.242363873479908 3724 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1807 st050092 58.9 µM -0.699469109144301 0.221281613989522 no 2599 0.242129455779515 3655 5008496
SGTC_1150 3909-7983 10.9 µM -0.699755646729337 0.221193564218285 no 2600 0.242039959018059 3678 23965914
SGTC_644 1498-1197 63.3 µM -0.699969375822674 0.221127900728996 no 2601 0.241973214845394 3699 6741615
SGTC_1028 k015-0029 4.8 µM -0.700697183418529 0.220904381778373 no 2602 0.241746007088815 3676 4588309
SGTC_321 4534-3890 65.3 µM -0.701277915854259 0.220726124292077 no 2603 0.241564796502667 3699 699746
SGTC_2383 9036125 200 µM -0.702171337089762 0.220452047010581 no 2604 0.24128615921212 3636 79580
SGTC_877 0771-0151 33.1 µM -0.702585680502677 0.220325003978813 no 2605 0.241156994450905 3700 6166523
SGTC_2070 5230947 200 µM -0.704405273329996 0.219767590496432 no 2606 0.240590211465948 3748 2835538
SGTC_3347 9188721 44.724 µM -0.705601871592692 0.219401466646367 no 2607 0.240217880017777 3707 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1212 0520-0165 585 µM -0.709275881177974 0.218279520350241 no 2608 0.239076646284187 3798 5403258
SGTC_120 rhodamine 6G 52.259 µM -0.709770368078592 0.218128769794463 no 2609 0.23892327363279 3735 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2998 9066762 71.4286 µM -0.710734872575337 0.217834901191912 no 2610 0.238624272742831 3723 4945196
SGTC_400 oxethazaine 37.5 µM -0.711023181475593 0.217747102578345 no 2611 0.23853493541144 3693 4621 A local anesthetic.
SGTC_2268 7933382 153.85 µM -0.711690589797017 0.217543935290169 no 2612 0.23832819805402 3720 935025 YOR257W CDC31
SGTC_1822 st052468 42 µM -0.712058753600397 0.217431908547767 no 2613 0.238214197119384 3704 2873678
SGTC_201 4262-0159 12.803 µM -0.712200486536427 0.217388790214318 no 2614 0.238170317861489 3680 1341029
SGTC_1271 0832-2808 169 µM -0.712595949540313 0.217268507620597 no 2615 0.238047909449484 3708 3663794
SGTC_528 3492-0019 172 µM -0.713254713464088 0.217068225743488 no 2616 0.237844077591167 3721 2869262
SGTC_138 0850-0259 40.9225 µM -0.71400127249352 0.216841380810409 no 2617 0.237613196299859 3723 6813004
SGTC_1570 verbenone 133 µM -0.71440376995434 0.21671913724174 no 2618 0.237488770739149 3699 29025 A natural terpanoid with antifungal properties.
SGTC_1327 1436-0082 2.18 µM -0.717304137951349 0.215839437907698 no 2619 0.236593227273968 3706 15992205
SGTC_2129 girgensonine 121.053 µM -0.717433532680016 0.215800239977869 no 2620 0.236553317546594 3762 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_843 0310-0051 143 µM -0.718397683273207 0.215508296909197 no 2621 0.236256057439393 3718 2065037
SGTC_395 anisomycin 6.25 µM -0.718722008035748 0.215410143465489 no 2622 0.236156110173475 3691 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1864 st057645 30.4 µM -0.718723969038448 0.215409550067746 no 2623 0.236155505921491 3725 688666
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.719743396383769 0.21510120063087 no 2624 0.235841500822945 3677 6708514
SGTC_1105 epirubicin 18.1 µM -0.722658199033752 0.214220966110694 no 2625 0.234944951421287 3707 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_141 0443-0274 32.331 µM -0.722681652123502 0.214213892075649 no 2626 0.234937745249861 3787 1627241
SGTC_3012 9080433 71.4286 µM -0.723395821653731 0.213998545875089 no 2627 0.23471836877426 3707 17688859
SGTC_992 3909-8734 162 µM -0.724413477700518 0.21369190607215 no 2628 0.234405963986421 3724 4288319
SGTC_2478 5763493 32.33 µM -0.72868845139531 0.2124065713929 no 2629 0.233096129341039 3684 1365576 YLR208W SEC13
SGTC_778 3456-2434 196 µM -0.729113768332321 0.212278941041338 no 2630 0.23296603658885 3756 5539063
SGTC_55 0767-0285 6.563 µM -0.729515066084064 0.21215855954472 no 2631 0.232843327628087 3687 3116166
SGTC_618 k072-0232 33.2 µM -0.729581463676198 0.212138645411246 no 2632 0.232823028013011 3722 5872756 YGL099W LSG1
SGTC_2444 5485484 36.41 µM -0.729692706828085 0.212105283533707 no 2633 0.232789020050403 3805 6790631
SGTC_683 panaxydol 45 µM -0.731461529941339 0.211575224912684 no 2634 0.232248647051557 3700 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_80 0159-0065 512.242 µM -0.732488242586782 0.211267908639765 no 2635 0.231935308199257 3665 1548079
SGTC_874 0599-0792 117 µM -0.733848607426498 0.210861126450635 no 2636 0.231520506045478 3736 765305
SGTC_2679 rapamycin 1 nM -0.733949148231101 0.210831080541946 no 2637 0.231489865585834 3711 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_472 calcifediol 10 µM -0.735209084314952 0.210454770482312 no 2638 0.231106083668032 3750 5283731 A vitamin D metabolite.
SGTC_2005 4024620 188 µM -0.7352294978108 0.210448676750733 no 2639 0.231099868554408 3732 236743
SGTC_1662 st014054 52 µM -0.735289445961072 0.21043078193655 no 2640 0.231081617219048 3742 2838777
SGTC_501 nsc-95397 161 µM -0.736166309772875 0.210169135927848 no 2641 0.230814746220919 3741 262093
SGTC_2906 7926292 26.41 µM -0.737409013616483 0.209798654980832 no 2642 0.23043682785394 3703 2966319
SGTC_2504 purpurogallin 52.29 µM -0.737664723262899 0.209722469226595 no 2643 0.230359106988756 3678 5281571 An antioxidant.
SGTC_2091 4-phenylthiadiazole 200 µM -0.738191200956059 0.209565662474894 no 2644 0.230199134543155 3738 270010
SGTC_2087 5276107 200 µM -0.739343352362381 0.209222744999685 no 2645 0.229849265417149 3712 144405
SGTC_827 3253-0474 693 µM -0.741887345420806 0.208466741416094 no 2646 0.229077796799907 3734 5402065
SGTC_2850 9015429 58.44 µM -0.743724388875343 0.207921826506587 no 2647 0.228521615752694 3797 6457570
SGTC_2823 7987624 58.44 µM -0.743960536538424 0.207851840018424 no 2648 0.22845017503651 3745 2239440
SGTC_697 0508-1955 564 µM -0.744065121181099 0.20782084897679 no 2649 0.228418539513246 3695 6243113
SGTC_2368 9071271 200 µM -0.746396427590283 0.207130733364892 no 2650 0.227713988321508 3756 27209959
SGTC_2401 5128683 200 µM -0.748094073754751 0.206629048562918 no 2651 0.227201708171753 3729 708373
SGTC_653 0203-0016 55.2 µM -0.748885854001795 0.206395309636403 no 2652 0.226963003589526 3782 295302
SGTC_1339 1486-1321 22.7 µM -0.749134482901658 0.206321945025468 no 2653 0.226888076554609 3785 3469382
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.749216513639237 0.206297743052102 no 2654 0.226863358757161 3774 5282362
SGTC_3080 9117754 49.47 µM -0.749713180337062 0.206151244720784 no 2655 0.226713733803099 3779 9550191
SGTC_766 1391-0721 126 µM -0.750982175422117 0.205777218271891 no 2656 0.226331691549789 3737 1020919 YIL115C NUP159
SGTC_3284 9108171 64.8615 µM -0.751321526560196 0.205677265440036 no 2657 0.226229588531183 3743 8687505
SGTC_1906 st060206 94.7 µM -0.75303718892566 0.205172373772172 no 2658 0.225713783408773 3734 5133468
SGTC_2972 9093619 59.92 µM -0.753134349869727 0.205143802930616 no 2659 0.225684592386684 3779 25236256
SGTC_2312 7706453 155.7 µM -0.753980465122782 0.204895096900071 no 2660 0.225430475929711 3796 976098
SGTC_1909 st060837 51.5 µM -0.755041972929421 0.204583332338958 no 2661 0.22511189915648 3788 678937
SGTC_3128 9127691 49.47 µM -0.756997931567945 0.204009607575226 no 2662 0.22452555083466 3777 41316314
SGTC_1461 k072-0203 53.8 µM -0.757399514514343 0.203891933374852 no 2663 0.224405273449994 3699 5418714
SGTC_3068 9116768 49.47 µM -0.757585563050102 0.203837430051144 no 2664 0.224349562786283 3716 41904888
SGTC_1623 st003709 20.3 µM -0.758308249325174 0.2036257999275 no 2665 0.224133234973679 3758 16192618
SGTC_2783 7738165 71.43 µM -0.758911066868889 0.203449372211602 no 2666 0.223952879145327 3764 17201110
SGTC_1222 0366-0074 1.18 µM -0.761004206976611 0.202837477494053 no 2667 0.223327277232996 3817 286520
SGTC_1231 0242-0792 125 µM -0.761695884146037 0.202635519094874 no 2668 0.223120766199681 3777 3707635
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.761831001717737 0.202596081014305 no 2669 0.223080437434285 3773 1273210
SGTC_577 r071-0003 38.6 µM -0.762157144081158 0.202500905572973 no 2670 0.22298311028615 3818 4568517 YMR134W ERG29
SGTC_262 fenpropimorph 62.5 µM -0.763116187350162 0.202221190782792 no 2671 0.222697053512164 3719 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2811 7967822 32.47 µM -0.764980229752588 0.20167818538928 no 2672 0.222141658653902 3833 2232244
SGTC_447 ml7 120 µM -0.765855718069506 0.201423452726037 no 2673 0.22188107839135 3804 4216 Selective myosin light chain kinase inhibitor.
SGTC_1624 st003710 6.25 µM -0.766727356103573 0.201170031995345 no 2674 0.221621817635907 3779 24207033
SGTC_1177 0983-0204 23.6 µM -0.76712002568858 0.201055929425197 no 2675 0.221505078247838 3817 766818
SGTC_2460 5552655 174.22 µM -0.767286697063183 0.201007509522249 no 2676 0.221455538019934 3760 5401989
SGTC_2685 mycophenolic acid 18.85 µM -0.768110510864551 0.200768285129683 no 2677 0.221210766447778 3771 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_933 2914-0560 114 µM -0.76849628926484 0.200656319068239 no 2678 0.221096197189139 3797 463887
SGTC_1708 st033234 31.827 µM -0.772393091738666 0.199527437120537 no 2679 0.2199408221073 3877 674664
SGTC_1396 3511-0007 98.6 µM -0.772543428406408 0.199483962144999 no 2680 0.219896317839478 3777 X1396
SGTC_1955 wogonin 32.4 µM -0.772706373969791 0.19943684731717 no 2681 0.219848086788469 3857 5281703 A flavanone.
SGTC_3111 9122088 49.47 µM -0.772719840415234 0.19943295386706 no 2682 0.219844101061339 3683 16876704
SGTC_3175 9106517 49.47 µM -0.773080562644415 0.19932867804491 no 2683 0.219737351844279 3819 41468073
SGTC_1899 st063254 59.6 µM -0.773413154181122 0.199232563201706 no 2684 0.219638953770003 3725 3093813
SGTC_568 1193-0097 7.48 µM -0.775040581397409 0.198762659444562 no 2685 0.219157840152569 3668 3646150
SGTC_2140 5586273 200 µM -0.775132051246611 0.198736268265431 no 2686 0.21913081706843 3759 854421
SGTC_832 4083-0019 164 µM -0.775238414124828 0.19870558275799 no 2687 0.219099396522082 3870 1990758
SGTC_1738 st035555 74 µM -0.775789296296707 0.198546699920689 no 2688 0.218936702457292 3825 5331140
SGTC_460 trequinsin 123 µM -0.776187309304237 0.198431954585305 no 2689 0.218819199062136 3832 5537 A vasodilator.
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.776798889069746 0.198255716922561 no 2690 0.218638716153723 3786 2333 A French combination drug.
SGTC_179 1273-0063 6.77 µM -0.78025095438711 0.197262715375646 no 2691 0.217621587676224 3806 3108139
SGTC_464 bw-b 70c 158 µM -0.780690049913908 0.197136623691823 no 2692 0.217492407085741 3866 5353454
SGTC_3062 9077494 49.47 µM -0.78276476611172 0.196541503324151 no 2693 0.216882630780009 3793 16459633
SGTC_2223 6903751 107.57 µM -0.78832059806673 0.194953213904022 no 2694 0.21525460109676 3770 5598863
SGTC_2997 9067075 71.4286 µM -0.789446181162924 0.194632387914443 no 2695 0.214925636731129 3848 27209819
SGTC_1202 1988-0068 29.6 µM -0.790086994408869 0.194449879919184 no 2696 0.214738482340369 3784 2850480
SGTC_3313 9133968 57.047 µM -0.790819100277473 0.194241498702887 no 2697 0.214524781182367 3800 1494643
SGTC_160 3453-0671 289.699 µM -0.791151898013105 0.194146818587498 no 2698 0.214427678661154 3856 5322268
SGTC_1832 st054113 55 µM -0.791986112537207 0.193909610242261 no 2699 0.214184386920186 3767 1251267
SGTC_3114 9122766 49.47 µM -0.792813185868676 0.193674606941212 no 2700 0.213943336477601 3831 17176985
SGTC_1371 2421-0008 32.7 µM -0.793106975299972 0.193591171896998 no 2701 0.213857749605215 3810 2827552
SGTC_3331 9141060 1.957 µM -0.793169378971964 0.193573452322375 no 2702 0.21383957270621 3800 4906567 YPR165W RHO1
SGTC_1504 k297-0033 30 µM -0.796020011871744 0.192765067727131 no 2703 0.2130102019438 3735 4388117
SGTC_77 0828-0286 12.516 µM -0.796113654572029 0.192738547498947 no 2704 0.212982989163028 3781 745345
SGTC_2753 fluvastatin 17.09 µM -0.796293122779287 0.192687727154013 no 2705 0.212930840965265 3868 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1903 st060211 78.3 µM -0.796455902026733 0.1926416397352 no 2706 0.212883548534474 3881 688960
SGTC_3096 9117468 49.47 µM -0.796950736525453 0.19250157943519 no 2707 0.212739821381065 3771 41316311
SGTC_3214 9129694 49.47 µM -0.797274536550059 0.192409963247199 no 2708 0.212645802718097 3791 17158655
SGTC_1826 st055655 41.6 µM -0.800806032813997 0.191412491301423 no 2709 0.21162197297878 3874 676168
SGTC_2112 5488546 200 µM -0.801862315747856 0.19111476066177 no 2710 0.211316303440268 3812 600757
SGTC_2512 diallyl trisulfide 49.23 µM -0.802264896956891 0.191001361335458 no 2711 0.211199871687505 3853 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1360 1598-0022 39.8 µM -0.802768345906794 0.190859607609252 no 2712 0.211054320574689 3909 761525
SGTC_1017 4239-0030 168 µM -0.804239983032173 0.190445615974906 no 2713 0.21062919579952 3890 1149593
SGTC_2950 9072895 21.46 µM -0.805277572160851 0.190154059693728 no 2714 0.210329760531261 3779 17332245
SGTC_315 k915-0449 187 µM -0.809215981655673 0.189049888796177 no 2715 0.209195461890207 3869 20970215 YNL149C PGA2
SGTC_800 3448-7362 155 µM -0.809547759494225 0.188957052395686 no 2716 0.209100071528508 3923 15991913
SGTC_1238 0333-0287 48.8 µM -0.810270084018852 0.188755032348586 no 2717 0.208892482615037 3851 7226
SGTC_2842 9000675 19.48 µM -0.810327560890156 0.188738962911151 no 2718 0.208875969548075 3872 2989072
SGTC_1641 st009299 47.1 µM -0.81047262642354 0.188698409103489 no 2719 0.208834295736768 3764 4046054
SGTC_223 busulfan 5 mM -0.810609732044605 0.188660085467364 no 2720 0.20879491311881 3857 2478 A DNA alkylator.
SGTC_2840 9008771 71.43 µM -0.812240533820338 0.188204613291166 no 2721 0.208326812572408 3812 2992978
SGTC_1192 1488-0095 21.4 µM -0.812577972587878 0.188110453664226 no 2722 0.208230032497809 3896 915875
SGTC_614 0462-0418 107 µM -0.813675494307434 0.187804400006118 no 2723 0.207915438207236 3686 5188303
SGTC_2921 7974240 10.71 µM -0.814060512080718 0.187697107293464 no 2724 0.207805143008189 3926 2979074 YDR527W RBA50
SGTC_820 1582-0060 59.9 µM -0.814152210406941 0.187671559350289 no 2725 0.207778879485424 3865 3848840
SGTC_1922 5578187 25 µM -0.814366940025952 0.187611742235435 no 2726 0.207717385966314 3817 1350412
SGTC_2164 5685496 200 µM -0.8145661292606 0.187556264730201 no 2727 0.207660352461496 3789 759046
SGTC_2443 5493264 126.67 µM -0.816588172612464 0.18699366603605 no 2728 0.207081908192661 3886 5340055
SGTC_2978 9011784 42.97 µM -0.818199789804073 0.18654600986489 no 2729 0.206621557584278 3880 2994934
SGTC_3079 9117512 49.47 µM -0.819215629654399 0.186264183043177 no 2730 0.206331699544907 3873 7185044
SGTC_1940 st075990 51.1 µM -0.819971076709335 0.186054768750539 no 2731 0.206116297873023 3940 1084979
SGTC_1388 3346-4487 254 µM -0.820011474005348 0.186043574499097 no 2732 0.206104783092497 3928 3345614
SGTC_3226 9131256 49.47 µM -0.820477620401795 0.185914433686186 no 2733 0.205971941066808 3740 17178073
SGTC_2864 9034755 47.6 µM -0.821181963138704 0.185719408637223 no 2734 0.205771314407126 3827 4930451
SGTC_513 4245-1575 41.7 µM -0.821278188411665 0.185692774734841 no 2735 0.205743914377795 3800 719745
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.823896809760756 0.184968884362671 no 2736 0.204999096645948 3936 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2706 st078239 82.5 µM -0.823942552429567 0.184956254884569 no 2737 0.204986100261744 3836 15434492
SGTC_2720 fluspirilene 36.88 µM -0.824395004298756 0.184831362506584 no 2738 0.204857576247584 3851 3396 An atypical antipsychotic.
SGTC_865 0488-0499 301 µM -0.825924377535348 0.184409590722058 no 2739 0.204423495548629 3819 9634651
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.827865713480084 0.183875070682951 no 2740 0.203873277112841 3856 66535 A nucleotide analog.
SGTC_2935 9038016 29.96 µM -0.828497330974483 0.183701371779867 no 2741 0.203694452926271 3891 6463195
SGTC_218 alverine citrate 93.75 µM -0.829720807396376 0.183365198761429 no 2742 0.203348327181004 3906 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2939 9044578 71.43 µM -0.830308025637269 0.183203985885826 no 2743 0.203182325811637 3837 2653634
SGTC_142 0335-0849 62.6745 µM -0.832561090136649 0.182586257950854 no 2744 0.202546155535224 3897 3889043 YPR107C YTH1
SGTC_253 dyclonine 31.25 µM -0.833976352833697 0.182198898049802 no 2745 0.202147154702205 3966 3180 An oral anasthetic.
SGTC_259 usnic acid 108.925 µM -0.836038436094612 0.181635422390538 no 2746 0.201566640201082 3933 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1223 0764-0573 147 µM -0.837086336720743 0.181349496082549 no 2747 0.201272019969072 3877 1609797
SGTC_117 lucigenin 22.078 µM -0.840191903928748 0.180503778878477 no 2748 0.200400398518034 3932 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1225 1216-0074 20.6 µM -0.842332471933826 0.179922295759849 no 2749 0.199800939943349 3891 4241466
SGTC_1973 st070275 50.2 µM -0.842334275008175 0.179921806452955 no 2750 0.199800435453777 3788 17118334
SGTC_3158 9100007 49.47 µM -0.843121311432181 0.179708305293544 no 2751 0.199580300469737 3915 19297233
SGTC_40 0327-0103 19.753 µM -0.843615022462982 0.179574456460558 no 2752 0.199442283462351 3779 409036
SGTC_167 3672-0051 66.205 µM -0.844560139782015 0.179318402757974 no 2753 0.199178236070742 3838 3237971
SGTC_735 3076-0345 636 µM -0.844666367439496 0.179289637637136 no 2754 0.199148571299279 3955 2888990
SGTC_2040 5100729 123 µM -0.846534039126813 0.178784369582549 no 2755 0.198627446567987 3903 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2016 5121758 140 µM -0.846693809032576 0.178741188105419 no 2756 0.198582905190449 3850 2795203
SGTC_200 k038-0079 37.545 µM -0.847139251855751 0.178620831654729 no 2757 0.198458754440162 3856 3436683
SGTC_2776 terbinafine 19.92 µM -0.849544034708696 0.177971953000222 no 2758 0.197789319143619 3923 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_576 1073-0113 22.7 µM -0.849704379746505 0.177928740282616 no 2759 0.197744731409591 4052 5439563
SGTC_1917 st066507 28.5 µM -0.850355457189659 0.177753343998045 no 2760 0.197563746324297 3888 3156428
SGTC_1178 0988-0033 191 µM -0.850388138153201 0.177744542822121 no 2761 0.197554664381597 3963 5392207
SGTC_1646 st011709 75.6 µM -0.851250773848612 0.177512329358395 no 2762 0.197315031749885 3841 5757843
SGTC_834 0312-0008 75.7 µM -0.851348677798325 0.177485986635355 no 2763 0.197287846005072 3893 6385573 YIL048W NEO1
SGTC_397 arbidol 50 µM -0.851841340273595 0.177353464869865 no 2764 0.197151079006231 3961 131410 A RNA synthesis inhibitor.
SGTC_2670 beta-carotene 100 µM -0.853053233384555 0.177027742492643 no 2765 0.196814892114029 3823 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_821 1114-0266 29.2 µM -0.854243205138761 0.176708279971891 no 2766 0.1964851243506 3945 3123235
SGTC_295 k015-0027 31 µM -0.855272664354033 0.176432203260497 no 2767 0.196200108498244 3928 3887424
SGTC_2928 9011484 9.79 µM -0.855447713603682 0.17638528633256 no 2768 0.196151669351642 3945 2994751
SGTC_860 0443-0016 25.1 µM -0.856018937312924 0.176232241120925 no 2769 0.195993652352153 3935 5337942
SGTC_2744 captopril 92.04 µM -0.856092689921133 0.176212487068213 no 2770 0.195973255878028 3872 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2630 antimycin a 100 µM -0.857947118552824 0.175716253694156 no 2771 0.195460832197975 3888 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1509 1326-1131 80 µM -0.859554007277749 0.175286977123025 no 2772 0.195017468557025 3805 768313
SGTC_3116 9124943 49.47 µM -0.866022740391851 0.17356560463356 no 2773 0.193238845658749 3908 41905195 YPL160W CDC60
SGTC_307 1501-1223 22.3 µM -0.866083281747756 0.173549545158214 no 2774 0.193222246296797 3930 2830329
SGTC_1274 0865-0114 173 µM -0.86708038062438 0.17328518622264 no 2775 0.192948984756238 3941 870624
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.867335016806592 0.173217716135494 no 2776 0.192879237878245 4006 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_851 0394-0702 453 µM -0.870286921398664 0.172436781343229 no 2777 0.192071812214801 3888 762646
SGTC_1332 1480-0653 17.5 µM -0.871200423340926 0.172195567502634 no 2778 0.191822364411302 3919 5749438
SGTC_2023 5144124 124 µM -0.872876807514769 0.171753471999987 no 2779 0.191365114432554 3928 2830192
SGTC_185 k048-0037 25.491 µM -0.873109937755587 0.171692048437258 no 2780 0.191301578855169 3974 6827589
SGTC_1089 terbinafine 2.25 µM -0.874562310072481 0.1713097033753 no 2781 0.190906051385874 3942 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1213 1315-0166 115 µM -0.877759616853889 0.170469914468198 no 2782 0.190037091941833 4037 768401
SGTC_1336 1486-0901 104 µM -0.879024156445373 0.170138505475974 no 2783 0.189694089120044 3958 5006114
SGTC_1033 k072-0102 21.3 µM -0.88071538979413 0.169695914919609 no 2784 0.189235942453734 3921 5965931
SGTC_2926 9010726 65.15 µM -0.883199214969062 0.169047245486068 no 2785 0.18856432284072 3989 2994293
SGTC_3348 9149464 3.537 µM -0.884147169757287 0.168800100457492 no 2786 0.188308386405811 3923 1951442
SGTC_231 b-estradiol 524 µM -0.884856674515663 0.168615274670652 no 2787 0.188116968918456 3904 450 A steroid.
SGTC_1783 st039459 87.517 µM -0.886996051897684 0.168058755315972 no 2788 0.187540513048851 4055 729761
SGTC_717 1532-0246 73.2 µM -0.88733305101256 0.167971199130324 no 2789 0.187449808156193 3955 9561992
SGTC_2781 5567276 71.43 µM -0.888056639921617 0.167783301757344 no 2790 0.187255142438596 4006 2853274
SGTC_1467 k284-1082 293 µM -0.888254788054136 0.167731871412756 no 2791 0.187201856841287 3902 3334705
SGTC_3274 9138298 49.47 µM -0.88870884396389 0.167614057206389 no 2792 0.187079788405566 3911 17015756
SGTC_1697 st025554 27.742 µM -0.889369767459283 0.167442662205081 no 2793 0.186902193683525 3928 1269519
SGTC_7 0192-1582 4.227 µM -0.890117469149265 0.167248899504022 no 2794 0.186701406873802 3994 252616
SGTC_2852 9023854 51.95 µM -0.893399575320207 0.166400070517437 no 2795 0.18582161500701 4049 19798528
SGTC_161 4065-0411 162.148 µM -0.895600786414245 0.165832347250855 no 2796 0.185233007773644 3994 1906281 YLR208W SEC13
SGTC_3232 9132874 49.47 µM -0.896193092130087 0.165679797320133 no 2797 0.185074822223105 3928 3784940
SGTC_1596 piperlongumine 63 µM -0.896826036733004 0.165516881059526 no 2798 0.18490587613358 4001 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2937 9044753 11.33 µM -0.90073513311281 0.164512999523593 no 2799 0.183864581981159 3932 6465530 YGL099W LSG1
SGTC_1018 4259-0013 28.1 µM -0.903108597603741 0.163905407757939 no 2800 0.183234130704792 4048 6801262
SGTC_3316 9136639 10.545 µM -0.904910955103771 0.163444989726883 no 2801 0.182756281403572 3998 4903665
SGTC_1862 st057513 3.81 µM -0.905231216680241 0.163363265853729 no 2802 0.182671453654481 3949 5393163
SGTC_1002 4049-0206 172 µM -0.906127798702957 0.163134618588099 no 2803 0.182434106571147 3985 4662749
SGTC_2874 9043904 71.43 µM -0.90718308424922 0.162865765181666 no 2804 0.182154993748309 3938 4463428
SGTC_2202 7226349 200 µM -0.90776970748128 0.162716436788798 no 2805 0.181999953070479 3925 844334
SGTC_597 k018-0003 82.8 µM -0.913778491651602 0.16119199534585 no 2806 0.180416625155809 4056 6786234
SGTC_1107 amlodipine 47 µM -0.913984585807263 0.16113987462461 no 2807 0.180362472616639 3750 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_455 paf C-16 10 µM -0.915497225889119 0.160757668122788 no 2808 0.179965329071284 3959 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_85 0868-0259 160.055 µM -0.915958278420043 0.160641289430015 no 2809 0.179844389042387 3929 83173
SGTC_2955 9076254 12.21 µM -0.916092206483963 0.1606074936787 no 2810 0.179809267553447 3926 16459619
SGTC_1671 st016596 74.5 µM -0.917271887835017 0.160310010483072 no 2811 0.179500092352598 4036 2829167
SGTC_1958 st076513 41.9 µM -0.918344797455339 0.160039765078946 no 2812 0.179219190623242 3964 732122 YGL099W LSG1
SGTC_2532 xanthone 78.9 µM -0.918570430291704 0.159982970417966 no 2813 0.179160152208313 4000 7020 An insecticide.
SGTC_591 4299-0174 154 µM -0.922816439243594 0.158916654040677 no 2814 0.178051436170017 3981 5509088
SGTC_2575 plumbagin 510 nM -0.922882433889391 0.158900117397814 no 2815 0.178034237887246 3915 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_740 k014-0057 261 µM -0.923376939861589 0.158776242191298 no 2816 0.177905402375997 3998 4012779
SGTC_1817 st052116 64.4 µM -0.924571420193019 0.158477282545676 no 2817 0.177594442522284 4018 4361398
SGTC_2475 5812728 15.03 µM -0.927332568638075 0.157787624607554 no 2818 0.176876944745581 3965 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_521 r062-0005 13.8 µM -0.927405405816333 0.157769458635542 no 2819 0.176858042488017 3903 2832033
SGTC_920 mycophenolic acid 780.421 nM -0.927562573246976 0.157730264939167 no 2820 0.176817259710788 4020 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2137 5261020 140 µM -0.928356927272443 0.157532270417919 no 2821 0.176611226772241 3967 763655
SGTC_234 nsc-17383 10.7 µM -0.930986403246701 0.156878033227837 no 2822 0.175930298767198 3997 408974
SGTC_673 1082-0474 110 µM -0.931306790078667 0.156798440470999 no 2823 0.175847445300207 4013 3098046
SGTC_2288 7946289 167.31 µM -0.932555614747853 0.156488452343952 no 2824 0.175524729616769 4072 1246052
SGTC_1447 4239-0816 81.9 µM -0.942683732058272 0.153989328027368 no 2825 0.172921348389121 4035 1341554
SGTC_2802 7925815 54.55 µM -0.945666699230122 0.153258339682544 no 2826 0.172159306301687 3991 1262923
SGTC_2396 5342950 42.78 µM -0.946538405190198 0.153045159399397 no 2827 0.171937021686949 4021 1886677
SGTC_1023 4482-3888 16 µM -0.946958964118831 0.152942379825472 no 2828 0.171829844915693 4058 3303168
SGTC_9 0092-0002 10.449 µM -0.947381690440655 0.15283911669455 no 2829 0.171722158803385 3991 759368
SGTC_2531 methyl deoxycholate 70.07 µM -0.948794900142741 0.152494235070597 no 2830 0.17136246809049 3987 16667744 Haematoxylin.
SGTC_377 3970-0964 33.1 µM -0.950652528642575 0.152041683025312 no 2831 0.170890396882319 3989 16481235
SGTC_1978 st071761 42 µM -0.950951498930898 0.151968931849751 no 2832 0.170814498647306 4055 5147680
SGTC_1951 sophoraflavanone G 9.2 µM -0.951727761150677 0.151780144842299 no 2833 0.170617533204965 4002 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_271 rotenone 740 µM -0.951794022216637 0.151764037370153 no 2834 0.170600727144664 4070 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1767 st044992 70.3 µM -0.95181030700646 0.151760078857383 no 2835 0.170596596930262 4087 9600693
SGTC_1459 k035-0031 35.7 µM -0.954191516825417 0.15118199199065 no 2836 0.169993353966316 3839 3877128 YMR208W ERG12
SGTC_250 brefeldin a 552.239 µM -0.954412571188998 0.151128400979598 no 2837 0.169937422678653 3899 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1319 1306-0155 43.7 µM -0.955778865187489 0.150797445883474 no 2838 0.169591984122397 4088 3122360
SGTC_3288 9119690 36.221 µM -0.957669545988729 0.150340265862595 no 2839 0.169114708997249 4037 17595618 YKL019W RAM2
SGTC_1726 st035556 14.5795 µM -0.957735561837032 0.150324319467305 no 2840 0.169098059846403 4151 5919439
SGTC_118 0083-0097 135.343 µM -0.958265511087505 0.150196348922743 no 2841 0.168964445157754 4064 5207356
SGTC_764 1951-2361 146 µM -0.959521449137692 0.149893358828394 no 2842 0.16864805974497 4025 5438930
SGTC_2543 pimpinellin 60.67 µM -0.960257351521002 0.149716014812704 no 2843 0.168462854412811 3873 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2279 7948423 32.93 µM -0.961084277959353 0.149516902134226 no 2844 0.168254897065323 3964 1247112
SGTC_2920 7982904 15.77 µM -0.962011220676747 0.149293917070528 no 2845 0.168021983784936 4058 6456808
SGTC_654 1124-0271 80.9 µM -0.964223342952372 0.148762667237612 no 2846 0.167466981826645 4043 5403748
SGTC_375 3970-0961 9.27 µM -0.965106857446984 0.148550841285927 no 2847 0.167245646296903 4002 2898222
SGTC_950 1165-0508 94.1 µM -0.966488066014984 0.148220095556086 no 2848 0.166900007855482 4072 6148369
SGTC_1866 st057638 64 µM -0.967335065097498 0.148017516107469 no 2849 0.166688279928222 4024 688802
SGTC_2728 chlorpromazine 9.18 µM -0.969103328097848 0.147595192586308 no 2850 0.166246818681276 4073 2726 A thorazine and dopamine antagonist.
SGTC_1529 apigenin 74 µM -0.970548967021737 0.147250523320356 no 2851 0.165886464729409 4091 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1661 st013063 9.66 µM -0.971544649193993 0.147013446754801 no 2852 0.165638565181546 4098 721395
SGTC_2438 5259590 200 µM -0.972566981545212 0.146770291130107 no 2853 0.165384279815415 4071 1201127
SGTC_2381 9035592 200 µM -0.974973641413179 0.14619894724253 no 2854 0.164786667487401 4057 4749657
SGTC_1770 st043884 66.3 µM -0.975768857605161 0.146010490755786 no 2855 0.164589510373058 4064 670149
SGTC_66 0109-0187 42.4 µM -0.978492881728734 0.145366168025389 no 2856 0.163915305110936 3968 759417
SGTC_2748 diazoxide 86.69 µM -0.979056324315972 0.145233134115358 no 2857 0.163776075138108 4094 3019 A potassium channel activatior.
SGTC_2662 daunorubicin 22.37 µM -0.980206553263109 0.144961809002011 no 2858 0.163492085181735 3956 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_317 4495-0002 170 µM -0.98027986349953 0.144944527578083 no 2859 0.163473995832172 4098 15991618
SGTC_1781 st038725 66.3 µM -0.981129361763 0.144744376485086 no 2860 0.163264476378231 4050 4270275 YIL048W NEO1
SGTC_3275 9138069 49.47 µM -0.984709150347905 0.143902984713695 no 2861 0.162383478392223 4154 17617007
SGTC_2556 citropten 84.59 µM -0.985491096828444 0.143719636315957 no 2862 0.162191451267185 4103 2775 A potential DNA crosslinker.
SGTC_432 NS 1619 61.3 µM -0.986546825089942 0.143472342597028 no 2863 0.16193242463773 4104 4552 A K+/calcium channel activator.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.988548879988256 0.143004170707876 no 2864 0.161441953976422 4045 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2218 6965428 192.983 µM -0.988609290501244 0.142990060032764 no 2865 0.16142716946202 3966 675684
SGTC_2800 7887935 81.82 µM -0.989746232436904 0.142724668843373 no 2866 0.161149085645042 4103 2961002
SGTC_1477 0139-0234 16 µM -0.991160627211921 0.142394978187124 no 2867 0.160803576378117 4099 620880
SGTC_2063 5246145 200 µM -0.992870727154951 0.141997048167398 no 2868 0.160386478461205 4110 711240
SGTC_1802 st050112 57.9 µM -0.994604565053147 0.141594363733474 no 2869 0.159964313188332 4074 4662563
SGTC_2067 5224629 34.075 µM -0.996747163837169 0.141097814164258 no 2870 0.159443625191495 4098 2835000
SGTC_3054 9094397 49.47 µM -0.997220585500106 0.140988257660161 no 2871 0.159328725499993 4096 2598354
SGTC_2576 guaiol 23.12 µM -0.9973796063875 0.14095147091424 no 2872 0.159290143212923 4015 227829
SGTC_2821 7996764 71.43 µM -1.00227372061149 0.139822484933845 no 2873 0.158105705577984 4149 2987135
SGTC_721 1187-1332 279 µM -1.00589310745825 0.138991520388501 no 2874 0.157233496092053 4036 25730
SGTC_1440 4100-1550 40 µM -1.00620980725291 0.138918970496446 no 2875 0.157157327743383 4091 742806
SGTC_2715 st079500 56.4 µM -1.00634208337834 0.1388886761902 no 2876 0.15712552166471 4056 28246688
SGTC_358 0075-0058 9.45 µM -1.01082874467454 0.137863790026105 no 2877 0.156049201410878 3926 1069125
SGTC_1263 0774-1208 64.8 µM -1.01088218090372 0.137851614783312 no 2878 0.156036411763455 4159 906585
SGTC_691 1548-0686 185 µM -1.01618142308625 0.136647845020345 no 2879 0.154771500505691 4101 46495133
SGTC_2611 pyromycin 23.93 µM -1.01664748962725 0.136542318813123 no 2880 0.154660577012923 4082 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_3093 9117344 49.47 µM -1.0178342562165 0.136273864288246 no 2881 0.154378364689346 4139 24824913
SGTC_1141 3253-0389 52.6 µM -1.02123559977579 0.135506459459031 no 2882 0.15357141481872 4114 5402031
SGTC_1475 4092-1048 11.7 µM -1.02129805827063 0.135492395431816 no 2883 0.15355662305157 4120 2881759
SGTC_3211 9128781 49.47 µM -1.02213939875898 0.135303044936059 no 2884 0.153357464086096 4129 17194361
SGTC_838 0109-0203 71.4 µM -1.02321240737993 0.135061818946924 no 2885 0.153103713904836 4110 759422
SGTC_2109 5483026 200 µM -1.02453845499692 0.134764114259534 no 2886 0.152790508537396 4122 759335
SGTC_353 1988-1175 58.3 µM -1.02651798205218 0.13432053830339 no 2887 0.152323745998692 3955 2788357
SGTC_545 4218-0007 221 µM -1.02798023184718 0.133993519312962 no 2888 0.151979563308694 4122 2840508
SGTC_3246 9135460 32.98 µM -1.02813730415972 0.133958424072687 no 2889 0.151942622556379 4085 41446951
SGTC_203 k066-0004 30.888 µM -1.03202701061835 0.133091347417377 no 2890 0.151029732134936 4209 6795412
SGTC_1063 disulfiram 1.84 µM -1.03438295475095 0.132568052893215 no 2891 0.15047858486778 4126 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_786 4544-0069 423 µM -1.03609509164331 0.132188649233564 no 2892 0.150078890940672 4128 748821 YLR208W SEC13
SGTC_2775 cyproheptadine 69.59 µM -1.03720162473522 0.13194384391799 no 2893 0.149820950520882 4132 2913 A selective serotonin reuptake inhibitor.
SGTC_2176 5809774 33.9695 µM -1.03992591726773 0.131342464701591 no 2894 0.149187160190741 4078 2870539
SGTC_2078 5212016 200 µM -1.04136728038551 0.131025054952614 no 2895 0.148852561004495 3985 1899708
SGTC_1714 st033236 13.627 µM -1.04305049673862 0.130655056804931 no 2896 0.14846245304062 4186 2916566
SGTC_610 4215-0184 155 µM -1.04550830358225 0.130116089679983 no 2897 0.147894052435355 4150 5605015
SGTC_2557 derrustone 83.84 µM -1.04591421148614 0.130027227266632 no 2898 0.147800321175825 4137 629853 An antioxidant.
SGTC_682 0kpi-0099 17 µM -1.04782625811394 0.129609202075708 no 2899 0.147359331123815 4169 1714895 YML126C ERG13
SGTC_1429 4049-0205 9.46 µM -1.0494798335654 0.129248437104149 no 2900 0.146978666004908 4160 22774478
SGTC_552 k242-0005 476 µM -1.04994347422413 0.129147408444828 no 2901 0.146872051027875 4218 4088318
SGTC_2195 6536160 144.242 µM -1.05058011976345 0.129008770737921 no 2902 0.146725737818306 4091 3834386
SGTC_1568 digitonin 820 nM -1.05178908264589 0.128745787757713 no 2903 0.146448164505278 4152 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1727 st034309 9.9045 µM -1.05244037298771 0.128604268289097 no 2904 0.146298776900166 4216 870305
SGTC_2553 4-methylesculetin 85.09 µM -1.05249980672088 0.128591359256592 no 2905 0.146285149577658 4174 5319502
SGTC_304 1310-0298 97 µM -1.05298290144115 0.128486464235456 no 2906 0.146174414348256 3952 1550234
SGTC_19 0279-0214 38.434 µM -1.05321628503603 0.128435810617057 no 2907 0.146120938211083 4227 3566274 YBR002C RER2
SGTC_3230 9131665 49.47 µM -1.05652286587264 0.127719638985144 no 2908 0.145364699892932 4111 15943720
SGTC_190 3970-0790 3.722 µM -1.05779786049651 0.127444231086716 no 2909 0.145073804217558 4061 2832352
SGTC_1473 k844-0725 134 µM -1.05900028315985 0.127184877905643 no 2910 0.144799825381404 4198 54682906
SGTC_3195 9113082 49.47 µM -1.05933648528495 0.127112427469684 no 2911 0.14472328218991 4138 17018038
SGTC_2389 9091542 195.52 µM -1.06034673478185 0.126894894897072 no 2912 0.144493442524522 4137 3626624 YOL127W RPL25
SGTC_826 1683-5028 118 µM -1.06138170107408 0.126672309041769 no 2913 0.144258234774742 4211 722377
SGTC_3151 9099821 49.47 µM -1.06172349459896 0.126598860703771 no 2914 0.144180615069012 4132 17174189
SGTC_589 1227-0070 34.1 µM -1.0630014402405 0.126324504551205 no 2915 0.14389064909953 4228 2841384
SGTC_2832 7992762 51.95 µM -1.06422795969371 0.126061578751917 no 2916 0.143612721934144 4102 2985177
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.06675097956541 0.1255219257464 no 2917 0.143042149902114 4142 688667
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.0681036893148 0.125233257197123 no 2918 0.142736870935964 4158 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2190 6049624 200 µM -1.07320516570662 0.124148772803704 no 2919 0.141589536740785 4044 2265554
SGTC_1171 0368-0077 21.4 µM -1.07412171046707 0.123954629820052 no 2920 0.141384067614099 4117 3239779
SGTC_2292 7671323 168.05 µM -1.07465248057262 0.123842299020527 no 2921 0.141265173103506 4239 937504
SGTC_1054 3429-0080 167 µM -1.07550951292241 0.123661069388172 no 2922 0.141073337732338 4217 1162877
SGTC_364 0083-0097 67.7 µM -1.07622640759891 0.123509616228812 no 2923 0.140913006084119 4232 5207356
SGTC_1389 3405-0187 19 µM -1.08291347675664 0.122103143904739 no 2924 0.139423414719801 4129 799890
SGTC_1163 k060-0048 49.9 µM -1.08742927220235 0.121159734336971 no 2925 0.138423570196211 4172 6809982
SGTC_1455 4262-0120 131 µM -1.08775561547657 0.121091756090622 no 2926 0.138351504177788 4245 1529587
SGTC_2369 9071472 200 µM -1.08806508270278 0.121027317962983 no 2927 0.138283188505856 4237 17296037
SGTC_1900 st060200 72.8 µM -1.09037737235775 0.120546610082489 no 2928 0.137773472574954 4168 688945
SGTC_2203 7227154 166.4 µM -1.09047777871654 0.12052576684578 no 2929 0.137751368303729 4192 896304
SGTC_2743 auranofin 4.32 µM -1.0905664823865 0.120507355067824 no 2930 0.137731842370882 4160 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1719 st032227 49.2 µM -1.09130947290636 0.120353214008668 no 2931 0.137568365434093 4189 3125804
SGTC_1439 4092-1168 46 µM -1.09141151153177 0.120332055892895 no 2932 0.137545924672323 4182 2886240
SGTC_3252 9135871 49.47 µM -1.09220153278711 0.120168330510144 no 2933 0.137372264461007 4205 17682838
SGTC_1071 trifluoperazine 6.31 µM -1.0960325213962 0.11937661604597 no 2934 0.136532271321813 4262 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_696 1560-0013 611 µM -1.09811196964796 0.118948420445605 no 2935 0.136077799632719 4249 1650269
SGTC_1140 3229-1848 2.98 µM -1.09918392298845 0.118728110245784 no 2936 0.135843924901169 4212 2849525
SGTC_2607 solasodine 47.35 µM -1.10465518619277 0.117608134883409 no 2937 0.134654514284263 4174 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1877 wortmannin 25 µM -1.10526512942729 0.117483743519893 no 2938 0.134522361476222 4206 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1234 0326-0494 15.5 µM -1.10642991626961 0.117246456633464 no 2939 0.134270241394497 4280 1547813
SGTC_1615 st002656 86.5 µM -1.10881202009749 0.1167622390897 no 2940 0.13375564198449 4199 1584458
SGTC_1172 0370-0043 85 µM -1.10885678276808 0.116753153635485 no 2941 0.133745985022082 4228 376585
SGTC_1746 st038117 42 µM -1.11003348767171 0.116514498241054 no 2942 0.133492298184657 4254 2898218
SGTC_2797 7859098 81.82 µM -1.11248871101221 0.116017652603552 no 2943 0.132964040649824 4199 972681
SGTC_2304 7443016 91.4 µM -1.11292453726886 0.115929615041986 no 2944 0.132870420360808 4140 939854
SGTC_1370 2001-0092 44.6 µM -1.114688561333 0.11557376406531 no 2945 0.132491952233423 4252 790957
SGTC_1804 st050076 49.1 µM -1.1153805764067 0.11543437820524 no 2946 0.13234368472005 4234 3895976
SGTC_630 4356-0227 183 µM -1.11883023527757 0.114741329016207 no 2947 0.13160628509821 4167 779312
SGTC_2738 aclarubicin 5.55 µM -1.12318906446459 0.1138698647662 no 2948 0.130678602990623 4182 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2919 7978188 46.38 µM -1.12536215541794 0.113437163184561 no 2949 0.130217800492478 4219 2980291
SGTC_2663 amphotericin b 100 µM -1.12631762958624 0.113247282653248 no 2950 0.130015549093343 4232 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2451 5856223 45.7 µM -1.12717619235034 0.1130768547481 no 2951 0.129833997121115 4196 2179896
SGTC_2177 5811945 192 µM -1.13041418167502 0.112435748783933 no 2952 0.129150870565039 4272 5343475
SGTC_1307 1187-1599 12.2 µM -1.13145394638319 0.112230432365642 no 2953 0.128932038354299 4199 1538471
SGTC_795 0685-0265 78 µM -1.13211493647732 0.112100049808005 no 2954 0.128793058037889 4234 302754
SGTC_1579 chlormadinone acetate 49.4 µM -1.13449432368098 0.111631604059421 no 2955 0.128293626714633 4265 45114258 A steroidal progestin.
SGTC_136 0097-0015 404.482 µM -1.13720190883739 0.111100249364129 no 2956 0.127726944593131 4223 4861337
SGTC_36 0335-0881 14.2 µM -1.13896635807456 0.11075495817839 no 2957 0.127358593098256 4120 23828853
SGTC_1759 st043059 70 µM -1.13911006269155 0.110726870025719 no 2958 0.127328625481215 4228 669426
SGTC_1425 4048-4433 7.33 µM -1.13954401572408 0.110642081610305 no 2959 0.127238160328267 4282 23734946
SGTC_668 1682-0499 62.6 µM -1.14115161826333 0.110328383840462 no 2960 0.126903416961336 4207 682214
SGTC_633 0437-0093 97.7 µM -1.1426388060303 0.110038751465656 no 2961 0.12659429330849 4174 2831118
SGTC_289 k017-0060 526 µM -1.14276441035945 0.110014314812042 no 2962 0.126568209501355 4206 5512909
SGTC_1825 st052143 62.6 µM -1.14479827879047 0.109619162216403 no 2963 0.126146364256894 4283 674173
SGTC_394 menadione 8.33 µM -1.14668155733232 0.109254176782932 no 2964 0.12575662771575 4225 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1987 st072290 61.9 µM -1.14936912444956 0.108734830924421 no 2965 0.125201902925796 4254 54697379
SGTC_3314 9135860 59.4275 µM -1.14957437658401 0.108695241064962 no 2966 0.125159608387377 4217 25252478
SGTC_948 3448-0295 75.3 µM -1.15041469712217 0.108533264751282 no 2967 0.124986554822356 4215 678569
SGTC_258 haloperidol 50.781 µM -1.15066728500917 0.108484611032505 no 2968 0.124934570174727 4239 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2600 tangeritin 87.95 µM -1.15168069705071 0.108289564415209 no 2969 0.124726153592239 4178 68077 A bioactive flavone.
SGTC_1912 st060209 90.8 µM -1.15290766281348 0.108053754039426 no 2970 0.12447414325942 4239 688787
SGTC_2833 9001315 45.46 µM -1.1534298164637 0.107953513629877 no 2971 0.124367004555517 4207 2989378
SGTC_1752 st044819 83.042 µM -1.15438587332657 0.107770148271684 no 2972 0.124171002094877 4226 441209 YML126C ERG13
SGTC_314 1671-0008 2.74 µM -1.15520114421754 0.107613962047584 no 2973 0.124004033140758 4128 3913060
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.15564470669903 0.10752905472127 no 2974 0.123913256764738 4271 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1982 st072467 71.9 µM -1.15853199708778 0.10697754546247 no 2975 0.12332350092694 4220 3163533
SGTC_664 1222-0054 14.9 µM -1.16056092377366 0.106591217226558 no 2976 0.122910252167396 4227 6813991
SGTC_205 1486-1330 71.903 µM -1.16064682378897 0.106574883241825 no 2977 0.1228927776303 4299 4118834
SGTC_1454 4239-0054 42.6 µM -1.16074114974392 0.10655694913663 no 2978 0.122873591021235 4353 1340767
SGTC_579 4491-1009 110 µM -1.16181013851224 0.106353855538493 no 2979 0.122656297444623 4360 1271041
SGTC_2747 doxorubicin 7.63 µM -1.16321540697593 0.106087298757075 no 2980 0.122371058519396 4229 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1139 k015-0024 46.9 µM -1.16364893127041 0.106005163687718 no 2981 0.12228315655955 4276 2766652
SGTC_637 1181-0519 7.26 µM -1.1643083067282 0.105880327196508 no 2982 0.122149545709409 4245 6252091 YGR060W ERG25
SGTC_784 4579-0127 173 µM -1.16471250354418 0.105803855040692 no 2983 0.122067693020498 4277 1948547
SGTC_2472 5377652 49.4 µM -1.16655783915739 0.105455233330691 no 2984 0.121694488983765 4326 1610903
SGTC_715 0868-0130 184 µM -1.1676638702305 0.105246680030248 no 2985 0.121471187927651 4312 2876258
SGTC_450 aminopyrene 156 nM -1.17038420325051 0.104735003843267 no 2986 0.120923194898564 4213 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_819 1013-0258 27.7 µM -1.17058104188897 0.104698049846421 no 2987 0.120883610661641 4260 5753198
SGTC_679 0422-0091 41.4 µM -1.17328184515496 0.10419196115315 no 2988 0.120341400087154 4274 627384 YHR062C RPP1
SGTC_67 0335-0847 266 µM -1.17527743069821 0.103819160200394 no 2989 0.119941870434329 4359 4552207 YOR254C SEC63
SGTC_1857 st056007 79.3 µM -1.17572044980552 0.103736529957198 no 2990 0.119853302002752 4235 619834
SGTC_2017 5132927 60.65 µM -1.17918121631638 0.103092682593812 no 2991 0.119163011998072 4256 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_672 1441-0018 53.7 µM -1.18335601824587 0.102319863210594 no 2992 0.118334040167151 4273 251141
SGTC_2868 9035608 32.47 µM -1.18367563031342 0.102260872247982 no 2993 0.118270744644984 4251 6462614
SGTC_1844 rapamycin 4 nM -1.18369533312745 0.102257236499185 no 2994 0.118266843510996 4154 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2345 9052315 157.45 µM -1.18372089739633 0.102252519279678 no 2995 0.118261781951457 4295 6469265
SGTC_1019 4262-0212 3.4 µM -1.18560128001188 0.101905977550065 no 2996 0.117889898265689 4287 4677213
SGTC_2376 9072922 81.32 µM -1.18665269778769 0.101712581395819 no 2997 0.117682320163763 4282 17087968
SGTC_401 neomycin 50 µM -1.18814648112421 0.101438276911174 no 2998 0.117387852279573 4248 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1051 3253-3903 78 µM -1.19035498216688 0.101033716157978 no 2999 0.116953449484561 4268 5509239
SGTC_1730 st033808 45.1 µM -1.19202077315674 0.100729349889573 no 3000 0.116626550046781 4211 1045166
SGTC_1684 st024538 14.6195 µM -1.19381612062564 0.10040206094726 no 3001 0.116274952154436 4230 6732859
SGTC_413 propylparaben 100 µM -1.19494655046032 0.100196383938235 no 3002 0.116053956878329 4248 7175 A pharmaceutical preservative.
SGTC_1246 0422-0085 105 µM -1.19779322403357 0.0996798063462065 no 3003 0.115498762888898 4313 264295
SGTC_3041 9091929 49.47 µM -1.1988095687245 0.0994958454288777 no 3004 0.115301000510555 4294 25236887
SGTC_1778 st046819 58.9 µM -1.19965589494273 0.099342847721839 no 3005 0.115136504421802 4316 671715
SGTC_2406 ethylparaben 405.7 µM -1.20233174936284 0.0988602420970123 no 3006 0.114617510310912 4286 8434 A possible steroid mimic.
SGTC_2037 5169046 200 µM -1.20712141176641 0.0980006864957354 no 3007 0.11369269501287 4340 5718022
SGTC_145 3737-0113 38.366 µM -1.20801608569483 0.097840736663181 no 3008 0.113520537528152 4250 6849351
SGTC_440 fluspirilene 35.1 µM -1.20828609726068 0.0977925015976241 no 3009 0.11346861713042 4358 3396 An atypical antipsychotic.
SGTC_574 1315-0397 40 µM -1.20861867372872 0.0977331138532039 no 3010 0.113404689434235 4277 6794277
SGTC_1097 itavastatin 7.23 µM -1.20916731306037 0.0976352018398707 no 3011 0.113299286380513 4309 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_3349 9149703 23.001 µM -1.21100668916377 0.0973074654324248 no 3012 0.112946420523595 4307 4910494
SGTC_710 3448-4187 58 µM -1.21140690458844 0.0972362628761429 no 3013 0.112869747227959 4268 3946412
SGTC_2617 dihydrotanshinone i 20.83 µM -1.21294714600285 0.09696259431694 no 3014 0.112575014367417 4254 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1706 st031321 9.9705 µM -1.21491269583188 0.0966141791376053 no 3015 0.112199695524325 4316 6103185
SGTC_2031 5180455 200 µM -1.21567549755626 0.0964792121951598 no 3016 0.112054280812466 4277 29949
SGTC_2252 omeprazole 400 µM -1.21636064805103 0.0963581026771768 no 3017 0.111923783841698 4285 4594 A proton pump inhibitor.
SGTC_2059 5238311 157 µM -1.21709292920446 0.0962287857413283 no 3018 0.111784430328067 4251 703021
SGTC_519 k048-0011 62.8 µM -1.21745181782938 0.0961654545303879 no 3019 0.111716178954655 4324 6836379
SGTC_3282 9108498 15.4605 µM -1.21907809131895 0.0958788584831445 no 3020 0.111407277211162 4273 16459645
SGTC_3026 9090633 49.47 µM -1.22789637390905 0.0943357567000078 no 3021 0.109742935450959 4310 25236842
SGTC_2090 5301565 104.445 µM -1.22800149340995 0.0943174730738774 no 3022 0.109723203681849 4300 2056344
SGTC_3046 9092212 49.47 µM -1.22931041063613 0.0940900295527284 no 3023 0.109477722741425 4389 25236637
SGTC_876 0720-0963 56.8 µM -1.23057956296047 0.0938698824241083 no 3024 0.109240076387346 4340 765861
SGTC_1269 0831-0796 3.05 µM -1.23380122578801 0.0933127606887424 no 3025 0.108638491279394 4347 927758
SGTC_1669 st015249 58.4 µM -1.2343354650954 0.0932206113810894 no 3026 0.108538962881228 4402 722793
SGTC_1665 st014639 11.4 µM -1.23459402615583 0.0931760371276157 no 3027 0.108490816704064 4379 981133 YIL048W NEO1
SGTC_287 k060-0039 29.6 µM -1.23514403856359 0.0930812709386855 no 3028 0.108388451019231 4358 5861974
SGTC_776 4476-4378 112 µM -1.23562053103082 0.0929992297149456 no 3029 0.108299824715853 4372 2892008
SGTC_2523 spermine 47.74 µM -1.23715991372109 0.0927345481356797 no 3030 0.108013860154274 4342 1103 A DNA binding polyamine.
SGTC_727 3032-0951 202 µM -1.24334246096421 0.0916771313358639 no 3031 0.106870831810786 4364 3652836
SGTC_1977 st070720 65.3 µM -1.24508359436282 0.091380959239282 no 3032 0.106550511948698 4358 682188
SGTC_1021 4476-0760 85.3 µM -1.24614030681846 0.0912015554289552 no 3033 0.106356444681439 4337 746768
SGTC_2555 cholic acid 100 µM -1.24699018102205 0.0910574572712107 no 3034 0.10620054895359 4271 6708657 Influences liver metabolism.
SGTC_2474 5321570 43.32 µM -1.24756954167865 0.0909593221591649 no 3035 0.106094369233853 4308 2841384
SGTC_393 acivicin 6.25 µM -1.24939474932591 0.0906506719714938 no 3036 0.105760363971168 4176 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2898 9056270 58.44 µM -1.25035764437171 0.090488155979206 no 3037 0.10558446485028 4335 19154699
SGTC_2988 9073640 71.4286 µM -1.25113115899905 0.0903577600914821 no 3038 0.105443314549994 4376 9102229
SGTC_857 0438-0306 1.35 µM -1.2546716929268 0.0897626923009271 no 3039 0.104798982889311 4393 4686136
SGTC_1960 st011366 51.8 µM -1.25597216219966 0.0895448517941026 no 3040 0.104563031597311 4352 3972846
SGTC_1539 benzyladenosine 56 µM -1.25611114748686 0.089521593760108 no 3041 0.104537837512733 4323 92208 A nucleotide analog.
SGTC_3024 9090631 49.47 µM -1.25748688179773 0.0892916183224144 no 3042 0.104288693138979 4296 25236383
SGTC_580 1123-0028 41 µM -1.25810080081999 0.0891891341398831 no 3043 0.10417765187984 4379 1677248 YPR107C YTH1
SGTC_3004 9076122 71.4286 µM -1.26006146637279 0.0888624178318089 no 3044 0.103823594789459 4340 44782551
SGTC_1426 4048-4480 71.7 µM -1.26127790099413 0.0886601651610122 no 3045 0.103604370163167 4349 14224343
SGTC_1346 1488-2224 62.4 µM -1.26452554427921 0.0881218698178151 no 3046 0.103020729076104 4349 3722427
SGTC_1655 st012546 55.1 µM -1.27246729143368 0.0868157986326917 no 3047 0.101603569199205 4335 720985 YLR208W SEC13
SGTC_1956 st077085 54 µM -1.27363167499485 0.0866255304333855 no 3048 0.101396990571751 4379 24208685
SGTC_793 0488-0545 106 µM -1.27452213646408 0.0864802334185177 no 3049 0.101239216301907 4380 292548
SGTC_969 1313-0238 134 µM -1.27663663511448 0.0861359398279655 no 3050 0.100865280841207 4369 5212874
SGTC_26 0302-0163 425.158 µM -1.28507564264752 0.0847720656164075 no 3051 0.0993829261156282 4416 3100915
SGTC_424 splitomicin 100 mM -1.28620556091064 0.0845906894859285 no 3052 0.0991856654167155 4378 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1125 tnp00248 1.32998 µM -1.28775387218099 0.0843426252248728 no 3053 0.0989158270197836 4396 24207736
SGTC_3025 9087895 49.47 µM -1.28939922786837 0.0840796116042335 no 3054 0.0986296648601664 4329 17173641
SGTC_1966 st070145 16.1 µM -1.28992635768599 0.0839954791474871 no 3055 0.0985381141281959 4344 3748532
SGTC_2540 epiandrosterone 100 µM -1.29291845696628 0.0835191230512979 no 3056 0.0980196316057014 4398 441302 A steroid.
SGTC_1120 ficusin 1.78878 µM -1.29490376762814 0.0832041746283419 no 3057 0.0976767143161186 4380 6199 A DNA cross-linker.
SGTC_927 2425-1185 123 µM -1.29529793422244 0.0831417506773423 no 3058 0.097608735779849 4297 730375
SGTC_1132 3456-3614 2.5 µM -1.29985227885052 0.0824230339282292 no 3059 0.0968258017817673 4379 3125502
SGTC_309 k408-0051 1.48 µM -1.30202591516946 0.0820816679599752 no 3060 0.0964537633712074 4276 3640463
SGTC_1848 st056003 16.4 µM -1.30418347227486 0.0817438816131926 no 3061 0.0960855168635336 4372 146492
SGTC_3269 9137823 49.47 µM -1.30587560978176 0.0814796951819295 no 3062 0.0957974310772228 4299 17682936
SGTC_2363 9053361 176 µM -1.30640195156697 0.0813976510505374 no 3063 0.0957079512682969 4418 6469797 YMR079W SEC14
SGTC_893 0958-0369 48.9 µM -1.30676174525489 0.081341603661133 no 3064 0.0956468205688842 4275 6819948
SGTC_3091 9116372 49.47 µM -1.30769331868348 0.0811966217158719 no 3065 0.0954886752108698 4428 17169793
SGTC_802 4112-3352 742 µM -1.31199286175177 0.0805300041422423 no 3066 0.0947612715317775 4415 704594
SGTC_1711 st032263 62.8 µM -1.31238525258567 0.080469372842421 no 3067 0.0946950901104546 4363 3958979
SGTC_2278 7948257 134.34 µM -1.31454244429309 0.0801366645111195 no 3068 0.0943318622013061 4381 1247028
SGTC_1785 bathophenanthroline 24 µM -1.31508279444376 0.08005348822575 no 3069 0.0942410391865275 4293 72812 An iron chelator.
SGTC_1540 guanosine 70.6 µM -1.31865701523443 0.0795049501317018 no 3070 0.0936419016660738 4296 6802 Guanosine is a purine nucleoside
SGTC_2191 5911152 200 µM -1.32059859012343 0.0792081699857207 no 3071 0.0933176216026735 4399 2875902
SGTC_2714 st079313 56.9 µM -1.32123185055035 0.0791115543540827 no 3072 0.0932120346590124 4371 2939799
SGTC_1353 1498-1206 8.11 µM -1.32227311468068 0.0789528842355295 no 3073 0.0930386110078105 4416 6756808
SGTC_1609 st001574 46.4 µM -1.32418672685872 0.0786619125525743 no 3074 0.0927205189606283 4377 3960012
SGTC_2250 alverine citrate 130 µM -1.3279721914505 0.0780887138543273 no 3075 0.0920936469076804 4263 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1636 st007707 68.9 µM -1.33040958992214 0.0777213210683434 no 3076 0.0916916783004924 4399 403051
SGTC_1531 st059297 52.4 µM -1.33868241706631 0.0764841266946529 no 3077 0.0903370413540094 4421 7566702
SGTC_527 4476-4215 268 µM -1.33891625378924 0.0764493756062961 no 3078 0.0902989688346625 4398 4418754
SGTC_910 3454-3003 490 µM -1.34216994895522 0.0759670810452927 no 3079 0.0897704489027772 4302 820824
SGTC_1359 1582-0056 520 nM -1.34248303365596 0.0759207950285569 no 3080 0.0897197139524452 4451 3661189
SGTC_3149 9097855 49.47 µM -1.34926155880525 0.0749239249353351 no 3081 0.0886264841351077 4404 25236625 YMR079W SEC14
SGTC_2354 9060492 162 µM -1.35292914082347 0.0743887383597904 no 3082 0.0880391343780895 4429 6471895
SGTC_680 0417-1641 114 µM -1.35468601113903 0.0741334058623052 no 3083 0.0877588083329043 4421 2835990
SGTC_2044 5102272 200 µM -1.35900048921486 0.0735092078018826 no 3084 0.0870732168415087 4397 592666
SGTC_5 0352-0601 109.883 µM -1.3602005173814 0.0733363098459533 no 3085 0.0868832394522771 4313 762456
SGTC_220 paclitaxel 373.376 µM -1.3620976329034 0.0730636115949101 no 3086 0.0865835376291196 4378 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_955 1216-0110 33 µM -1.36282662516253 0.0729590302424593 no 3087 0.0864685789131079 4377 3619719
SGTC_2933 9026794 32.47 µM -1.36490750740624 0.0726611368420278 no 3088 0.0861410611889662 4344 17586027
SGTC_127 0180-0333 59.125 µM -1.36718993157952 0.0723354633893681 no 3089 0.0857828902005006 4320 771601
SGTC_3254 9136651 49.47 µM -1.37054962776363 0.0718581131806204 no 3090 0.0852576973820612 4369 16454030
SGTC_3200 9114385 49.47 µM -1.37365290028088 0.0714193457161452 no 3091 0.0847747327786997 4406 17018030 YLR208W SEC13
SGTC_770 0389-1121 67.2 µM -1.37483815553018 0.0712523077917047 no 3092 0.0845908130208313 4471 6753108
SGTC_2321 7390090 138.78 µM -1.3758904779715 0.0711042555766504 no 3093 0.0844277718329083 4428 649046
SGTC_919 tnp00227 403.569 nM -1.37785188836483 0.070828933590908 no 3094 0.0841245109105816 4370 1269246 A methoxyflavone. YNL221C POP1
SGTC_438 sphingosine 6.67 µM -1.37903961093019 0.0706626122861292 no 3095 0.083941270663182 4345 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2122 5258151 111.688 µM -1.38017418138125 0.0705040145285693 no 3096 0.0837665107124174 4433 2173356
SGTC_2863 9028737 58.44 µM -1.3821976782505 0.0702218361554753 no 3097 0.0834555064080776 4418 6460917
SGTC_3270 9137563 49.47 µM -1.38271343005295 0.0701500532182783 no 3098 0.0833763761410583 4409 17015724
SGTC_2831 7999036 19.48 µM -1.38381291424444 0.0699972141578827 no 3099 0.0832078738337244 4408 2988270
SGTC_2308 7584454 197.62 µM -1.38494514839768 0.0698400904341078 no 3100 0.083034620141204 4441 893577
SGTC_924 2046-0044 21.3 µM -1.38602762077736 0.0696901262524876 no 3101 0.0828692347929422 4410 3623589
SGTC_2172 5754775 163.918 µM -1.38674039607185 0.0695915148129642 no 3102 0.0827604689444459 4416 2263357
SGTC_1761 st044296 37 µM -1.39252453370448 0.0687952567121037 no 3103 0.0818818088475477 4437 1826700
SGTC_1515 3460-0031 42.1 µM -1.39426726931462 0.0685567298570855 no 3104 0.0816184554455193 4410 2876596
SGTC_3030 9087619 49.47 µM -1.39534465148484 0.0684095888058007 no 3105 0.0814559666351472 4444 25236973
SGTC_3296 9122258 64.045 µM -1.39783115617549 0.0680709301838458 no 3106 0.0810818879775683 4405 4730474
SGTC_137 0438-0332 85.389 µM -1.40056862611949 0.0676995888356111 no 3107 0.0806715541701613 4378 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1764 st044502 93.5 µM -1.40625490241304 0.0669332415226711 no 3108 0.0798242232069532 4464 8407
SGTC_2194 5927483 104.545 µM -1.40671088118933 0.0668720804484515 no 3109 0.0797565689229905 4476 760979
SGTC_748 act1.228 77.9 µM -1.40704372267141 0.0668274632578322 no 3110 0.0797072121032891 4419 4421505 YNR035C ARC35
SGTC_1824 st053723 68.6 µM -1.41127120287218 0.0662627742827883 no 3111 0.0790823311101079 4462 675225
SGTC_2284 7945075 39.21 µM -1.41217393224968 0.0661426716890569 no 3112 0.078949377002587 4403 1245402
SGTC_3253 9135987 49.47 µM -1.41256935360697 0.0660901164471731 no 3113 0.0788911926438689 4442 4182430
SGTC_191 3914-0123 66.505 µM -1.41374876668646 0.0659335534216695 no 3114 0.078717840599841 4479 3144412
SGTC_2201 6605497 169.863 µM -1.4141904968235 0.0658749893019368 no 3115 0.078652988741841 4381 670741
SGTC_4 0960-0234 25.671 µM -1.41817001107012 0.0653492055037573 no 3116 0.078070567530535 4443 6821112
SGTC_794 k038-0031 316 µM -1.41999120052473 0.0651096736199481 no 3117 0.077805121422511 4434 6624242
SGTC_313 3474-0040 5.03 µM -1.42482348661044 0.0644774095580107 no 3118 0.0771041156783857 4463 1043375 YIL048W NEO1
SGTC_1491 4138-0063 26.5 µM -1.43024836713714 0.0637733041848594 no 3119 0.0763228740513344 4461 23883227
SGTC_1687 st020778 55.3625 µM -1.43205633863009 0.0635399776962177 no 3120 0.0760638492397771 4466 4259299
SGTC_2953 9074162 66.49 µM -1.43271274116775 0.0634554306969844 no 3121 0.0759699734075011 4438 16451992
SGTC_1392 3455-1037 33.9 µM -1.4336404275313 0.0633360907196683 no 3122 0.075837450217501 4443 981132
SGTC_1254 0550-0035 264 µM -1.43431824971196 0.0632490044431153 no 3123 0.0757407323557591 4461 15121435
SGTC_2851 9015922 71.43 µM -1.43443353367284 0.0632342020950366 no 3124 0.0757242919400149 4467 2996893
SGTC_2187 6125751 200 µM -1.43982491972694 0.062544961441885 no 3125 0.0749584695058564 4482 874498
SGTC_2212 7123476 200 µM -1.44081223367519 0.0624193789928906 no 3126 0.0748188681669311 4481 1085715
SGTC_1769 st044406 64.4 µM -1.45240289844134 0.0609597536603035 no 3127 0.0731948054324208 4447 670903
SGTC_2196 6573537 42.6665 µM -1.45600919688165 0.0605110927364076 no 3128 0.0726950386178356 4495 2903087
SGTC_144 4161-2749 112.381 µM -1.45740449489847 0.0603381979604491 no 3129 0.0725023785279371 4456 797501 YMR168C CEP3
SGTC_2479 5617353 43.85 µM -1.46016378274831 0.0599974263865555 no 3130 0.0721225331982166 4481 2731746
SGTC_165 k038-0023 64.381 µM -1.4612741825343 0.0598607182422656 no 3131 0.0719701060220086 4454 46368543
SGTC_1709 st033179 39.1045 µM -1.46730512508778 0.0591224688276231 no 3132 0.0711465350791988 4478 573381
SGTC_1066 ketoconazole 628 nM -1.46850557240269 0.0589763774963574 no 3133 0.0709834718542962 4538 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_300 r073-0011 5.04 µM -1.46990537814791 0.0588063825964643 no 3134 0.0707936913906423 4488 2735780
SGTC_2188 6126565 140.678 µM -1.47170115485831 0.0585888636491548 no 3135 0.0705507978085119 4391 874518
SGTC_1189 1431-2119 7.28 µM -1.47599782093048 0.0580709805677221 no 3136 0.069972238605098 4464 3107275
SGTC_2416 tofa 880 nM -1.47785108459416 0.0578487175412524 no 3137 0.069723820751319 4426 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1896 st058441 89 µM -1.48105682515781 0.0574658306649509 no 3138 0.0692957157989664 4500 688759
SGTC_845 0330-0138 4.51 µM -1.48405051695447 0.0571100732831951 no 3139 0.0688977596424478 4442 9039800
SGTC_551 k048-0028 34.9 µM -1.48485325392413 0.0570149748580263 no 3140 0.0687913506701201 4453 6836383
SGTC_2189 6047310 154.431 µM -1.489215356913 0.0565003841543999 no 3141 0.0682153340749541 4475 711535
SGTC_1980 st071811 45.7 µM -1.4900075233334 0.0564073273780332 no 3142 0.0681111288914401 4545 4974850
SGTC_3231 9132313 49.47 µM -1.49155892753113 0.0562254319778879 no 3143 0.0679074061394538 4444 4905967
SGTC_2463 5473429 200 µM -1.49317173994622 0.0560368273321267 no 3144 0.0676961187523774 4493 5399405
SGTC_2643 anethole 100 µM -1.49457919870942 0.0558726450841898 no 3145 0.0675121491257681 4491 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_3170 9103054 49.47 µM -1.50276910642983 0.0549247965235378 no 3146 0.066449297539507 4464 16432970
SGTC_671 0560-0003 407 µM -1.50383462864888 0.0548024194320061 no 3147 0.0663119762198807 4451 3238678
SGTC_2430 5571206 200 µM -1.50417915388465 0.0547628962501543 no 3148 0.0662676218848596 4471 1731771
SGTC_3078 9116413 49.47 µM -1.50630214827252 0.0545198479765852 no 3149 0.065994813458509 4451 17177322
SGTC_2316 5844804 197.44 µM -1.50633296155948 0.0545163266482946 no 3150 0.065990860314672 4512 776813
SGTC_73 0327-0325 16.231 µM -1.50669740631327 0.0544746917126213 no 3151 0.0659441183460422 4308 53298
SGTC_2293 7624732 200 µM -1.50747262163106 0.0543862131281899 no 3152 0.0658447782080133 4394 894453
SGTC_529 4076-0302 30.3 µM -1.50771375087038 0.0543587152256092 no 3153 0.0658139023089265 4460 5816522
SGTC_2583 asiatic acid 100 µM -1.50880902464929 0.0542339507824743 no 3154 0.065673796913897 4496 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1480 1070-0044 41.2 µM -1.51475915112566 0.053560116534394 no 3155 0.0649167043268957 4538 3124987
SGTC_892 0929-0076 29 µM -1.5166466678805 0.0533477521138242 no 3156 0.0646779580554472 4485 5751038
SGTC_518 1021-0119 62.6 µM -1.51703795260757 0.0533038123088571 no 3157 0.0646285510771535 4478 1097762
SGTC_976 1348-1067 47.6 µM -1.51715547771865 0.0532906202837051 no 3158 0.0646137170708538 4521 5310671 YGL099W LSG1
SGTC_2737 bleomycin 30.5 nM -1.51963231871532 0.0530131999471633 no 3159 0.0643017052666853 4599 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_194 1486-1323 56.904 µM -1.52159245655099 0.0527944661644878 no 3160 0.0640556144271356 4584 5178754
SGTC_1035 k081-0041 55.2 µM -1.52160528386837 0.0527930371127483 no 3161 0.0640540064017246 4520 731709
SGTC_972 1319-0219 195 µM -1.5216564564194 0.0527873364425878 no 3162 0.0640475917513846 4495 23903702
SGTC_2117 5521686 200 µM -1.52593267144484 0.0523126851452411 no 3163 0.0635133165337925 4498 803312
SGTC_1470 k295-0292 231 µM -1.52697236004114 0.0521977954717041 no 3164 0.0633839422787402 4570 5045612
SGTC_277 nystatin 15.5 µM -1.52960603490682 0.0519076607335404 no 3165 0.0630571373794883 4532 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2508 celastrol 40.54 µM -1.5327364790298 0.0515644686513881 no 3166 0.0626703986016378 4433 122724 Celastrol is a natural product and antioxidant.
SGTC_3356 9151811 4.48 µM -1.53489677147306 0.051328688678088 no 3167 0.0624045933532335 4539 1859254 YPR165W RHO1
SGTC_1932 st074806 40.9 µM -1.53556945789475 0.0512554452787795 no 3168 0.0623220048558306 4537 17251235
SGTC_2045 5106652 78.05 µM -1.53888548418199 0.0508956043730329 no 3169 0.0619161277632773 4513 673349
SGTC_2518 prenyletin 46.28 µM -1.54203332470926 0.050555877814209 no 3170 0.061532747866515 4542 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_525 k781-2675 26.7 µM -1.54666210641016 0.0500596064996984 no 3171 0.0609723725592124 4461 3651118 YDL195W SEC31
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.54755537918904 0.0499642835521679 no 3172 0.0608646907379077 4545 4174840
SGTC_2204 7233102 200 µM -1.54898870151992 0.04981163335744 no 3173 0.0606922180715922 4507 2172480
SGTC_2513 baicalein 25.65 µM -1.55212669879405 0.0494787324908614 no 3174 0.060315955391473 4503 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2143 5623677 140.463 µM -1.55311816775167 0.0493739204450925 no 3175 0.0601974532593042 4483 5375313
SGTC_1199 1638-0010 4.46 µM -1.55557712890617 0.0491147389507775 no 3176 0.0599043403876223 4520 3111136
SGTC_1954 st077032 68.9 µM -1.55883332764558 0.0487731999383199 no 3177 0.0595179169341202 4461 698907
SGTC_2237 6667747 47.222 µM -1.5599263308733 0.048658982513999 no 3178 0.059388645639724 4518 729940 YDL015C TSC13
SGTC_3089 9117425 49.47 µM -1.56092371949946 0.0485549433672652 no 3179 0.0592708750136142 4506 9401657
SGTC_3065 9113888 49.47 µM -1.56285867903551 0.0483536120298069 no 3180 0.0590429193104228 4540 16648368
SGTC_18 0111-0177 500 nM -1.56338547240993 0.0482989153029833 no 3181 0.0589809775519283 4599 721752
SGTC_1402 3909-7673 35.9 µM -1.56627113692466 0.0480001755687636 no 3182 0.0586425775461852 4553 5328014
SGTC_3322 9139058 2.11 µM -1.56785673552781 0.0478366564037609 no 3183 0.0584572853140765 4559 4908926 YPR165W RHO1
SGTC_2729 fluphenazine 10.66 µM -1.57430153362925 0.047176604419789 no 3184 0.0577088776965126 4500 3372 An atypical antipsychotic.
SGTC_1267 0828-0272 9.49 µM -1.57469031830926 0.0471370212116834 no 3185 0.0576639718304181 4578 745334
SGTC_558 k064-0027 21.3 µM -1.57636623164104 0.0469666966523985 no 3186 0.0574707129699864 4537 5088526
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.57914750261137 0.0466851231183751 no 3187 0.0571511140397416 4533 3256 An antibiotic and ribosome inhibitor.
SGTC_343 4130-2827 29.8 µM -1.58642846702525 0.0459544151287118 no 3188 0.0563210735387356 4519 1118244
SGTC_1574 spiramycin 23.7 µM -1.58809886532406 0.0457880787949922 no 3189 0.0561319924337884 4504 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2759 disulfiram 3.38 µM -1.59272917448006 0.0453295266214529 no 3190 0.0556104798662842 4450 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_620 0109-0052 432 µM -1.59300212730988 0.0453026110701779 no 3191 0.0555798569086735 4584 493037
SGTC_89 0302-0250 142.109 µM -1.59462146872082 0.0451431940351274 no 3192 0.0553984543903221 4611 4203518 YLR208W SEC13
SGTC_523 1934-0222 13.7 µM -1.59536206829477 0.0450704358533076 no 3193 0.055315646593252 4511 1361595
SGTC_2251 lansoprazole 556 µM -1.6004333032486 0.0445747584396303 no 3194 0.0547512459996682 4525 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2024 5144227 134 µM -1.60535698398422 0.0440977141506704 no 3195 0.05420763262927 4520 3475211
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.61817113541539 0.0428754581326105 no 3196 0.0528128607883068 4582 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2439 5492030 7.2 µM -1.62344266783732 0.0423806562091218 no 3197 0.0522474049349678 4569 5722370
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.6238210094058 0.0423453223182183 no 3198 0.0522070074022897 4605 165521
SGTC_1964 st076914 61 µM -1.62939546876065 0.0418274721989401 no 3199 0.0516146637080647 4587 24208661
SGTC_504 lovastatin 124 µM -1.63166695930103 0.0416179336453953 no 3200 0.0513748320328225 4550 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2442 5158906 48.48 µM -1.63408766961255 0.0413955668108333 no 3201 0.0511202217674689 4555 1893835
SGTC_154 3389-1638 511.116 µM -1.63419946358812 0.0413853207047369 no 3202 0.0511084875805151 4559 5238686
SGTC_3336 9143619 71.43 µM -1.64007524016825 0.0408496823177033 no 3203 0.050494761906384 4565 45595730
SGTC_1663 st014140 55.4 µM -1.64276408863296 0.0406064485237425 no 3204 0.0502158764851879 4632 4207120
SGTC_1749 st037932 54.2 µM -1.65582468951577 0.0394416552955028 no 3205 0.0488786631687276 4548 594497
SGTC_3265 9137266 49.47 µM -1.66123309649194 0.038967339719208 no 3206 0.0483333204572474 4552 17224265
SGTC_2529 gangaleoidin 93.61 µM -1.66600282094268 0.0385529003080188 no 3207 0.0478564262869048 4552 4565183
SGTC_2587 piperic acid 92.2 µM -1.66883155897408 0.0383088139862212 no 3208 0.0475753832023069 4516 5370536
SGTC_1285 0929-0069 65.5 µM -1.66992773361374 0.0382145665723877 no 3209 0.0474668312206244 4613 1206237
SGTC_1031 k035-0009 16 µM -1.67958938328722 0.0373920251046356 no 3210 0.0465186173694121 4609 5180959
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.68097228508211 0.0372754840989674 no 3211 0.0463841489876445 4579 7104
SGTC_2804 7954240 19.48 µM -1.68375618849149 0.0370417767403676 no 3212 0.0461143986998066 4585 828705
SGTC_1845 st056753 3.01 µM -1.68910524396537 0.0365960877473179 no 3213 0.0455996315499188 4554 5375839
SGTC_2686 alizarin 95.37 µM -1.68986921954199 0.036532792011316 no 3214 0.0455264887437081 4545 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2200 6600604 21.907 µM -1.69061353752139 0.0364712110887286 no 3215 0.0454553187077896 4612 2904777
SGTC_189 3970-0742 2.116 µM -1.70307704341748 0.0354526071564693 no 3216 0.0442768257047554 4573 2891807
SGTC_1116 jasmonic acid 1.58368 µM -1.71408555219532 0.0345724272990731 no 3217 0.0432565074109887 4632 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_803 4488-1585 147 µM -1.71611155871048 0.0344124111408394 no 3218 0.0430708130369408 4592 747204
SGTC_1937 st074714 47.2 µM -1.71914039503463 0.03417432581097 no 3219 0.0427944054647336 4540 17250970
SGTC_74 000s-0487 160.283 µM -1.71990429724834 0.034114492668985 no 3220 0.0427249196412309 4476 677548
SGTC_1400 3771-8998 51.5 µM -1.71999945532482 0.0341070453867052 no 3221 0.0427162702952336 4562 670767
SGTC_2139 5578692 56.4705 µM -1.73318087180154 0.0330882817679815 no 3222 0.0415317628767838 4586 650991 YMR113W FOL3
SGTC_3038 9091290 49.47 µM -1.74219198250228 0.0324063640840345 no 3223 0.0407374282178434 4594 25236843
SGTC_79 0052-0007 94.094 µM -1.76176927020864 0.0309647646978635 no 3224 0.0390541443645479 4601 2801472
SGTC_2267 7931562 200 µM -1.77048937883729 0.0303399505029327 no 3225 0.0383228260908549 4577 934880
SGTC_359 0081-0058 15.9 µM -1.78182768844776 0.0295431954965263 no 3226 0.0373886677607515 4601 3494159
SGTC_2145 5634607 200 µM -1.78215898453773 0.0295201786443872 no 3227 0.0373616546087591 4624 308662
SGTC_2671 danthron 100 µM -1.78372110335936 0.0294118506523793 no 3228 0.0372344976160797 4606 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1934 st074720 32.6 µM -1.7893762209035 0.0290224428230804 no 3229 0.036777123129654 4570 17250992
SGTC_2489 cantharidin 73.42 µM -1.79253393265255 0.0288068752002376 no 3230 0.0365237393500897 4576 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3124 9127567 49.47 µM -1.79263812843118 0.0287997848112957 no 3231 0.0365154027893858 4586 17592030
SGTC_1364 1653-0028 37.6 µM -1.79680873424454 0.028517169519603 no 3232 0.0361829946457431 4639 5718652
SGTC_956 1185-0240 191 µM -1.79920972760793 0.0283555185670772 no 3233 0.0359927556340291 4613 1416193
SGTC_1588 farnesol 29.9 µM -1.80813300928253 0.0277614123756741 no 3234 0.0352929008946855 4649 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1062 mesoridazine 14.2 µM -1.80844026936643 0.0277411413414164 no 3235 0.0352690026321626 4690 4078 A neuroleptic.
SGTC_1 0258-0098 57.368 µM -1.81069828654043 0.0275925500327206 no 3236 0.035093784123727 4550 6790032 YDR047W HEM12
SGTC_379 3970-0972 5.9 µM -1.81109622366794 0.0275664322266572 no 3237 0.035062978998818 4636 2898042 YBL034C STU1
SGTC_451 chloral hydrate 100 µM -1.81191981227021 0.0275124430989209 no 3238 0.034999293810196 4611 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_616 4092-0450 108 µM -1.81300827557859 0.0274412257707019 no 3239 0.0349152724717234 4637 787165
SGTC_350 k064-0020 19.8 µM -1.82728807186335 0.026521061972256 no 3240 0.0338282338675568 4638 2790705
SGTC_3300 9124615 50.48 µM -1.83617928835694 0.0259612584998699 no 3241 0.0331655724052495 4630 24824903
SGTC_1306 1185-0270 9.02 µM -1.85029661005425 0.0250927383226164 no 3242 0.0321354054931504 4649 1548076
SGTC_1190 1486-1332 13 µM -1.85115455876675 0.0250407504843955 no 3243 0.0320736604765864 4656 4150046
SGTC_1722 st034304 3.6505 µM -1.85291048997901 0.024934630419789 no 3244 0.031947594657562 4585 4036148 YLR033W RSC58
SGTC_1421 4029-0249 71.4 µM -1.88118500214768 0.0232771270451179 no 3245 0.0299733785890198 4712 2894095
SGTC_2263 7948595 193.29 µM -1.88339049050121 0.0231518308051073 no 3246 0.029823734065092 4667 2971371
SGTC_2803 7707263 71.43 µM -1.88364956768902 0.0231371496818951 no 3247 0.0298061961754357 4615 2199229
SGTC_3251 9135047 49.47 µM -1.89809881238759 0.0223306749106365 no 3248 0.0288415332972523 4689 17682963
SGTC_2502 avocadyne acetate 18.59 µM -1.90359250185397 0.0220303336838936 no 3249 0.0284816380570677 4628 3952079
SGTC_1295 1013-0063 9.78 µM -1.91378519687872 0.0214821261748151 no 3250 0.0278238038629771 4672 6826038
SGTC_907 3448-6986 75.5 µM -1.91547651713098 0.0213922844020103 no 3251 0.0277158805572702 4666 590582
SGTC_3194 9111903 49.47 µM -1.92806466252014 0.0207335406492588 no 3252 0.0269235418535798 4636 17087251
SGTC_2870 9038528 12.99 µM -1.94290104115445 0.0199792775184773 no 3253 0.0260140580614959 4671 6463316
SGTC_1344 1488-0097 29.1 µM -1.94867323499651 0.0196921825178369 no 3254 0.0256672300393262 4693 747966
SGTC_2217 6934799 96.0675 µM -1.95099572246107 0.0195776597278931 no 3255 0.0255287773155788 4652 675606
SGTC_2286 7945697 125 µM -1.96709581856605 0.0187992058584014 no 3256 0.0245860826202286 4632 1245733
SGTC_3056 9094900 49.47 µM -1.97168250519498 0.0185823155351534 no 3257 0.0243229310103314 4652 25236784
SGTC_2390 9097792 176.6 µM -1.97641625407905 0.0183607086794942 no 3258 0.0240538260640479 4700 4497149
SGTC_2702 st077768 96.8 µM -1.9798492569563 0.0182014071251461 no 3259 0.0238602348233263 4653 6484119
SGTC_69 0096-0274 206.684 µM -1.98663497950213 0.0178899923924519 no 3260 0.023481430981655 4690 6741392
SGTC_1670 st016595 4.04 µM -1.99822693680194 0.0173685171927398 no 3261 0.0228460312287191 4704 597879
SGTC_3332 9141069 11.198 µM -2.01849895540457 0.0164877445550375 no 3262 0.0217696614233931 4640 17332883
SGTC_911 3456-4043 236 µM -2.01853106712098 0.0164863802843927 no 3263 0.0217679909935203 4661 914281
SGTC_60 0986-0278 202 µM -2.03358539010909 0.0158573461950508 no 3264 0.0209967080538237 4650 3110598
SGTC_3323 9138564 53.9225 µM -2.04105814284581 0.0155528217829682 no 3265 0.0206225241030973 4705 43912313 YNL103W MET4
SGTC_868 0527-0199 213 µM -2.0433544613497 0.0154602577320644 no 3266 0.0205086809851489 4679 2849450
SGTC_2141 5621638 7.665 µM -2.04903222543859 0.0152334163789915 no 3267 0.0202294819441447 4698 2856238
SGTC_2994 9053520 71.4286 µM -2.04930411738037 0.0152226257026288 no 3268 0.0202161931505418 4684 4647384
SGTC_2828 7998861 71.43 µM -2.04936703755413 0.0152201295021084 no 3269 0.0202131189645365 4702 2988188
SGTC_753 1322-0200 289 µM -2.05251479883762 0.0150956979521405 no 3270 0.0200598291655158 4727 5403907
SGTC_2827 7993847 71.43 µM -2.05484587621328 0.0150041143658071 no 3271 0.0199469467661057 4704 2985692
SGTC_1664 st014217 9.02 µM -2.06252046546187 0.0147059611047187 no 3272 0.0195791055865684 4736 3982782
SGTC_762 1165-0429 115 µM -2.06834365366437 0.0144831476976345 no 3273 0.0193038597975223 4706 5967793
SGTC_3182 9108849 49.47 µM -2.07129421016475 0.0143713636687263 no 3274 0.0191656550133645 4692 17133045
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -2.07674417943531 0.0141668401592987 no 3275 0.0189125883383106 4597 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2041 5107442 45.335 µM -2.0771875074623 0.0141503140270396 no 3276 0.0188921282127007 4718 793005
SGTC_943 3253-1379 105 µM -2.0778016342002 0.0141274484010265 no 3277 0.0188638166302909 4670 668464
SGTC_3127 9126946 49.47 µM -2.07990948429334 0.0140492093596417 no 3278 0.0187669179734572 4662 27243249
SGTC_1001 4048-4355 44.4 µM -2.08286827902207 0.0139400151907115 no 3279 0.0186316158645326 4689 21824233
SGTC_1995 st072814 61.1 µM -2.08535729859764 0.0138487254744503 no 3280 0.0185184399426639 4706 5769371
SGTC_3139 9095020 49.47 µM -2.09097346640106 0.013644633615022 no 3281 0.0182652212848527 4629 25236292
SGTC_516 3992-2719 87.3 µM -2.09160162043073 0.0136219686525137 no 3282 0.0182370837306043 4619 5350887 YDR037W KRS1
SGTC_86 0417-1630 471.922 µM -2.10899749997821 0.0130070738926424 no 3283 0.0174723987135929 4723 3634867
SGTC_2894 9048625 32.47 µM -2.14672725391777 0.0117553835215266 no 3284 0.0159075008588178 4722 4092861
SGTC_1629 st005085 44.9 µM -2.16499183732714 0.0111879546497643 no 3285 0.015194155192364 4687 24207091
SGTC_3289 9119912 71.43 µM -2.16698583412138 0.0111274728089585 no 3286 0.0151179671441402 4710 17014829
SGTC_2344 7990960 76.95 µM -2.18267121065977 0.0106615404723076 no 3287 0.0145300157521716 4687 140813
SGTC_1735 st034310 56.75 µM -2.18602609134842 0.0105641195004616 no 3288 0.0144068482534275 4703 871153
SGTC_436 n,n-dimethylsphingosine 3.3 µM -2.22671828702978 0.00944282949934873 no 3289 0.0129830537335364 4719 5282309
SGTC_2241 6772625 37.8075 µM -2.23306844208042 0.00927758109694914 no 3290 0.0127722156543717 4586 2285411
SGTC_1849 st056239 19.2 µM -2.23951605948046 0.00911239102978259 no 3291 0.0125611787906306 4720 5393181
SGTC_2561 acetosyringone 100 µM -2.24365622861579 0.00900768140054419 no 3292 0.0124272642231373 4701 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2980 9014342 25.29 µM -2.29215546729406 0.00785737867851403 no 3293 0.0109483368213722 4719 2996599
SGTC_2927 9011802 47.9 µM -2.30363113542996 0.00760489131716806 no 3294 0.0106216792631927 4700 43912568
SGTC_2053 5265679 138 µM -2.31437092163957 0.00737509475903092 no 3295 0.0103236922604796 4685 764595
SGTC_1126 isoteolin 1.0172 µM -2.33622693574336 0.00692626839007442 no 3296 0.00973970858354302 4708 133323
SGTC_879 0831-1030 162 µM -2.35707083728091 0.00652087240716634 no 3297 0.00920986637492164 4747 1549252
SGTC_371 0195-0006 7.36 µM -2.35788451669535 0.00650548172187951 no 3298 0.00918970482054095 4636 3928593
SGTC_836 0330-0104 1.35 µM -2.36790773293041 0.00631851239662638 no 3299 0.0089444982724683 4767 46494820
SGTC_2477 5967686 25.23 µM -2.37569854856868 0.00617648729766733 no 3300 0.0087578830371457 4727 776118
SGTC_2689 tacrolimus 100 µM -2.37704856735434 0.00615216625598306 no 3301 0.00872589506496305 4730 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2755 lomerizine 42.69 µM -2.3934870189982 0.00586275704254997 no 3302 0.00834453593663156 4713 3949 A calcium channel blocker.
SGTC_1362 1611-0397 101 µM -2.40141034571207 0.00572762526509038 no 3303 0.00816600529828697 4746 27816
SGTC_2156 5649887 115 µM -2.41523115694669 0.00549851783600316 no 3304 0.00786261319349478 4764 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1069 diphenylcyclopropenone 8.49 µM -2.42656320694289 0.0053167805434799 no 3305 0.00762129746214136 4767 65057 A dermal irritant. YDR527W RBA50
SGTC_785 1270-0111 65.3 µM -2.43074334196957 0.00525110266066888 no 3306 0.00753394200602077 4714 6741994
SGTC_2461 5755302 26.15 µM -2.44134002832231 0.00508783134690067 no 3307 0.00731643487637741 4746 2788904
SGTC_2391 6285546 200 µM -2.44514015935371 0.00503039025109865 no 3308 0.00723979295481467 4753 846083
SGTC_2964 9083345 53.42 µM -2.45071227308766 0.00494720881419568 no 3309 0.00712869344420848 4727 17741579
SGTC_251 melphalan 456.522 µM -2.45840068152128 0.00483444736772131 no 3310 0.00697786860351888 4770 460612 A DNA alkylator.
SGTC_2916 7875993 68.79 µM -2.46850233792612 0.00468977720402327 no 3311 0.0067839882883111 4710 1299250
SGTC_2965 9082772 38.63 µM -2.47941470409047 0.00453784738562599 no 3312 0.00657991005308882 4744 16459634
SGTC_2160 5660466 132.927 µM -2.48293312564273 0.00448980681625297 no 3313 0.00651527739192116 4754 2859134
SGTC_957 1187-1561 14.1 µM -2.49767401197214 0.00429343538866003 no 3314 0.00625055467601157 4717 1538454
SGTC_474 dl-dihydrosphingosine 5 µM -2.50753793259943 0.00416635687767746 no 3315 0.00607877658505179 4752 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1294 1000-1494 117 µM -2.52735783120599 0.00392114060075861 no 3316 0.0057462171485176 4776 712797 YDL207W GLE1
SGTC_999 SEC7.066 22.7 µM -2.53356412032427 0.00384705821246354 no 3317 0.00564545405081488 4759 740511 YDR170C SEC7
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -2.54017588864537 0.00376951803205963 no 3318 0.00553983665644459 4710 5355888
SGTC_3072 9116419 49.47 µM -2.54298906756394 0.00373695332277484 no 3319 0.00549543339462024 4753 17170162
SGTC_1081 sertraline 6 µM -2.55499838374174 0.00360075558120991 no 3320 0.00530941455241245 4759 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2239 6685329 187.64 µM -2.5868754054676 0.00326058842038661 no 3321 0.00484253028607171 4747 805680
SGTC_2382 9035899 200 µM -2.62162278468297 0.00292295911296417 no 3322 0.00437561162470342 4770 6462679
SGTC_3224 9130643 49.47 µM -2.62478875821372 0.00289382043423807 no 3323 0.00433513698720726 4762 17644395
SGTC_1441 4106-0040 13 µM -2.63603821141266 0.00279239049500588 no 3324 0.00419401425843718 4796 2904180
SGTC_2701 st077767 14.721 µM -2.64186218073665 0.00274114933579903 no 3325 0.00412257995818839 4760 5721188
SGTC_1638 st008370 60.6 µM -2.70967012271198 0.00220400687795579 no 3326 0.00336750779084077 4746 24207134
SGTC_3011 9081274 71.4286 µM -2.72610997916814 0.00208906074860058 no 3327 0.00320428204901216 4785 6625322
SGTC_1443 4112-3303 14 µM -2.74553676971405 0.00196025693431617 no 3328 0.0030205998627939 4791 704433
SGTC_2107 5363541 170.161 µM -2.74579119125643 0.00195861899479609 no 3329 0.0030182585339631 4765 244052
SGTC_1465 k213-0056 144 µM -2.79737782083407 0.00165106742383295 no 3330 0.00257596242090983 4741 24048857 YMR208W ERG12
SGTC_2871 9038510 12.99 µM -2.8004200244021 0.00163438403769092 no 3331 0.00255180760196798 4759 4945164
SGTC_2628 lathosterol 100 µM -2.8160430122698 0.00155110242176183 no 3332 0.00243095784983707 4771 6710616
SGTC_252 miconazole 1.30953 nM -2.85221292319451 0.00137293625166732 no 3333 0.00217080042177818 4752 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1965 Pectolinarigenin 58.4 µM -2.86560660169252 0.0013118521175368 no 3334 0.00208105556769014 4785 5320438 An anti-inflammatory.
SGTC_3003 9075612 71.4286 µM -2.93086148418945 0.0010482784278105 no 3335 0.00169011732806204 4790 6501993
SGTC_2347 9049783 174.81 µM -2.96851022288171 0.000919260203337685 yes 3336 0.00149623574001273 4782 6467988 YPL169C MEX67
SGTC_2029 5175081 200 µM -3.01334619765166 0.000784710932572701 yes 3337 0.00129191987219152 4774 1380876
SGTC_2971 9092186 9.93 µM -3.02765392406844 0.00074575097099609 yes 3338 0.00123230080601538 4764 25236400
SGTC_312 4092-0653 6.84 µM -3.03749886591851 0.000719986849873853 yes 3339 0.00119275151149291 4743 1148278
SGTC_2384 9036245 200 µM -3.04286530147595 0.000706290913630574 yes 3340 0.00117168600363835 4792 6462766
SGTC_2789 5281112 71.43 µM -3.04992251916412 0.000688645432194634 yes 3341 0.00114450204945542 4780 765948
SGTC_2900 5328528 85.29 µM -3.06727739395235 0.000646967370549914 yes 3342 0.00108009145162841 4770 795359
SGTC_192 3455-0609 60.9 µM -3.0768594982141 0.000624965802194273 yes 3343 0.00104596939572738 4807 3769639
SGTC_2065 5221596 34.26 µM -3.16542776224781 0.000451934889388382 yes 3344 0.000774275540374801 4788 788581
SGTC_2914 7968218 45.32 µM -3.26776868484829 0.000307710148634254 yes 3345 0.000541994604083813 4799 2977111
SGTC_3010 9080089 71.4286 µM -3.30008637150418 0.000271941412266491 yes 3346 0.000483275382714826 4800 17027233
SGTC_1376 2910-0861 41.3 µM -3.39621067393949 0.000187131894397613 yes 3347 0.000341628743016901 4792 1112859
SGTC_750 4073-0104 132 µM -3.58737479360753 8.65490868170212e-05 yes 3348 0.000167012018592996 4713 22330957
SGTC_64 000l-0018 272.079 µM -3.69931327537656 5.41615816899478e-05 yes 3349 0.000108091811436329 4783 6811119
SGTC_1256 0570-0116 285 µM -3.80095082802275 3.4999105116092e-05 yes 3350 7.20709535342432e-05 4801 410638
SGTC_2694 st077685 81.9 µM -3.83925899254434 2.96070609455001e-05 yes 3351 6.17031000868762e-05 4789 2838096
SGTC_158 k038-0087 26.446 µM -3.87732399846207 2.50351760451932e-05 yes 3352 5.28058375380867e-05 4790 X158
SGTC_2908 7930301 100 µM -3.90692736438191 2.19510225152296e-05 yes 3353 4.67386193306136e-05 4797 2223178
SGTC_3145 9085516 49.47 µM -4.05030462585753 1.1466128504083e-05 yes 3354 2.55755005909381e-05 4803 25236195
SGTC_3138 9097216 49.47 µM -4.08066007632303 9.96625788152615e-06 yes 3355 2.24539946860494e-05 4799 25237486
SGTC_2352 9027995 87.8 µM -6.83571652794543 5.56750097163728e-13 yes 3356 4.07980754646495e-12 4795 2997347