SGTCid condition conc unit YDL119C|YDL119C.score YDL119C|YDL119C.strain.pval YDL119C|YDL119C.strain.significant YDL119C|YDL119C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_227 fluconazole 33.516 µM 14.4449334285068 1.64119826048736e-42 yes 1 1.3490892959242e-47 6 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2648 atorvastatin 78.68 µM 10.8545481499824 6.97177656024022e-25 yes 2 9.48714442795494e-28 3 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1495 4469-0029 237 µM 10.7454970621225 2.00307179476478e-24 yes 3 3.11129181747032e-27 13 793680 SGTC_1226 3909-7979 35.4 µM 10.6139377744205 7.05694812747861e-24 yes 4 1.28348698831235e-26 4 6615510 SGTC_171 k064-0041 9.68 µM 10.0546575998071 1.25896230734596e-21 yes 5 4.38127543112545e-24 3 53325 SGTC_1290 0986-0249 10.2 µM 9.52864246974261 1.28456808360135e-19 yes 6 7.96766709909266e-22 1 53329 SGTC_2619 obliquin 87.91 µM 9.47701256631314 1.99638704125968e-19 yes 7 1.30833544064099e-21 26 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1712 st032288 53.4 µM 9.11682995977069 4.05412170509097e-18 yes 8 3.86769101931067e-20 31 2883011 SGTC_1788 fluconazole 20 µM 8.52883287988475 4.33196522083116e-16 yes 9 7.39157840438609e-18 16 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2647 atorvastatin 60.16 µM 8.39669807260493 1.18721656964822e-15 yes 10 2.29604405013457e-17 5 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_137 0438-0332 85.389 µM 8.32334876884905 2.06406250756702e-15 yes 11 4.2756179156283e-17 33 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2021 4019055 173 µM 8.27483615234548 2.96799587978454e-15 yes 12 6.43161892369281e-17 21 44827708 YER133W GLC7 SGTC_690 glyoxal 20.3 µM 7.98316769033532 2.5236319246494e-14 yes 13 7.13124675481479e-16 29 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_350 k064-0020 19.8 µM 7.652726754942 2.60749706482286e-13 yes 14 9.83808609801946e-15 5 2790705 SGTC_607 4491-0986 66.8 µM 7.43090549416374 1.1854049505202e-12 yes 15 5.39283775224995e-14 3 698981 YDR232W HEM1 SGTC_142 0335-0849 62.6745 µM 7.10340295790558 1.02525986280485e-11 yes 16 6.08609140167592e-13 51 3889043 YPR107C YTH1 SGTC_254 nsc-64875 3.808 µM 7.04977424397098 1.44678621403645e-11 yes 17 8.96041516708427e-13 11 56993 SGTC_916 4466-0038 42 nM 7.00912050829604 1.87527306705314e-11 yes 18 1.19910415471331e-12 19 5722064 YGL116W CDC20 SGTC_1097 itavastatin 7.23 µM 6.9608485940071 2.54698679555969e-11 yes 19 1.69114563569038e-12 4 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1067 clotrimazole 1.36 µM 6.94016211841068 2.90226726575695e-11 yes 20 1.95825114648823e-12 6 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_528 3492-0019 172 µM 6.78797446568723 7.4987977690763e-11 yes 21 5.68593854344236e-12 101 2869262 SGTC_1310 1188-0297 994 nM 6.66844866561183 1.55830185051869e-10 yes 22 1.29260721227022e-11 6 1588352 SGTC_794 k038-0031 316 µM 6.66563640272965 1.58511534380331e-10 yes 23 1.31760464645431e-11 44 6624242 SGTC_73 0327-0325 16.231 µM 6.61158603833757 2.19727957220001e-10 yes 24 1.90112011414611e-11 11 53298 SGTC_1475 4092-1048 11.7 µM 6.58817889158131 2.52908174955246e-10 yes 25 2.2262698998751e-11 8 2881759 SGTC_584 0986-0246 15.4 µM 6.49474922139751 4.41265994883459e-10 yes 26 4.15859192603474e-11 1 53315 YDR232W HEM1 SGTC_490 phenamil 164 µM 6.30181059720795 1.35993370579936e-09 yes 27 1.47094267626059e-10 2 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_252 miconazole 1.30953 nM 5.98892447682409 7.87975397460516e-09 yes 28 1.05616607721101e-09 15 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2739 tacrine 100.86 µM 5.9316754070644 1.0768261884972e-08 yes 29 1.49929491580714e-09 2 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_284 0988-0104 32.6 µM 5.81994178550721 1.9648356251816e-08 yes 30 2.94340635378493e-09 1 4666532 SGTC_754 3474-0146 171 µM 5.78735854149025 2.33674024754429e-08 yes 31 3.57509277926354e-09 6 24762078 SGTC_258 haloperidol 50.781 µM 5.72167517628451 3.30495711118123e-08 yes 32 5.27394125872575e-09 9 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_86 0417-1630 471.922 µM 5.67849070284725 4.14258669596689e-08 yes 33 6.79442089220552e-09 93 3634867 SGTC_294 k038-0071 157 µM 5.58469438651458 6.72908022248451e-08 yes 34 1.17055766049967e-08 21 24152826 SGTC_547 1120-0019 610 nM 5.54740483780937 8.14333128971832e-08 yes 35 1.44970436501136e-08 10 3676939 SGTC_1353 1498-1206 8.11 µM 5.51505161925859 9.59977017831835e-08 yes 36 1.74338802040155e-08 22 6756808 SGTC_915 methyl methanesulfonate (MMS) 110 mM 5.47064275368138 1.20146421348018e-07 yes 37 2.24203178069116e-08 15 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1191 1487-1166 10.6 µM 5.42352622875705 1.52159165152067e-07 yes 38 2.9217318112936e-08 14 3955771 SGTC_514 4466-0038 2.65 nM 5.3163087975051 2.58618286169826e-07 yes 39 5.29466914946747e-08 97 5722064 SGTC_3347 9188721 44.724 µM 5.31248047223383 2.63515001747241e-07 yes 40 5.40715091462762e-08 9 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1873 rapamycin 2 nM 5.10120140285483 7.27643726269718e-07 yes 41 1.68752085702526e-07 47 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_383 2324-0395 7.37 µM 5.08153766421496 7.98231487264953e-07 yes 42 1.87195878869024e-07 21 3146421 SGTC_902 1120-0002 2.07 µM 5.06228381838318 8.73698415325852e-07 yes 43 2.07131844661876e-07 26 3280475 SGTC_1371 2421-0008 32.7 µM 5.03893917240846 9.74417779890135e-07 yes 44 2.3405960924987e-07 13 2827552 SGTC_2721 ifenprodil 61.44 µM 4.74762978932428 3.6561927032455e-06 yes 45 1.02907158197799e-06 9 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2765 myclobutanil 7.74 µM 4.68983822961398 4.71219150873546e-06 yes 46 1.36710563675553e-06 30 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_526 4469-0568 170 µM 4.6255439017076 6.22823743669474e-06 yes 47 1.86808327565048e-06 24 2901964 SGTC_183 3914-0051 30.55 µM 4.61712777584406 6.45817254499275e-06 yes 48 1.94543858741211e-06 8 1596232 SGTC_2584 androsterone 48.74 µM 4.52928171150107 9.39479047416865e-06 yes 49 2.95922721691168e-06 95 2754130 A steroid. SGTC_3311 9131146 2.8755 µM 4.40062996811453 1.60746673343286e-05 yes 50 5.39685270408622e-06 104 4900406 YPR165W RHO1 SGTC_1437 4092-1038 11.6 µM 4.381481527917 1.73915534575589e-05 yes 51 5.89375194404208e-06 12 3977136 SGTC_1098 clofazimine 15.1 µM 4.33722691792666 2.08379347289673e-05 yes 52 7.21458186829236e-06 16 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_46 0329-0187a 2.197 µM 4.23893433945821 3.09506576604808e-05 yes 53 1.12291663719065e-05 61 46494817 SGTC_1466 k213-0079 57.5 µM 4.21647726392809 3.38397324784011e-05 yes 54 1.24074146672891e-05 10 3657981 SGTC_1877 wortmannin 25 µM 4.17079237565901 4.05228650539761e-05 yes 55 1.51771164671692e-05 87 312145 A covalent inhibitor of PI 3-kinase. SGTC_1311 1190-0148 100 µM 4.15609067489232 4.29265735992893e-05 yes 56 1.61869690490008e-05 26 1961333 SGTC_635 k038-0028 24.7 µM 4.12696632770666 4.8091628323874e-05 yes 57 1.83790095723334e-05 42 4035102 SGTC_864 0469-0573 172 µM 4.06580326437938 6.09091287363069e-05 yes 58 2.39336519566612e-05 16 689425 SGTC_1374 2889-5571 141 µM 4.044726731769 6.60275500836098e-05 yes 59 2.61920951445464e-05 33 2853281 SGTC_1660 st012960 28.1 µM 4.03570818386333 6.83392475301339e-05 yes 60 2.72189221359241e-05 34 24207266 SGTC_3218 9131285 49.47 µM 3.97354542735104 8.64716897514654e-05 yes 61 3.54053226993648e-05 43 17156417 SGTC_625 k213-0058 121 µM 3.94793181543517 9.51865185457706e-05 yes 62 3.94146236676564e-05 104 3655420 SGTC_978 1416-0512 87.4 µM 3.92100525530041 0.000105234064980811 yes 63 4.40901697742899e-05 31 6814003 SGTC_2148 5546263 113.568 µM 3.9070473160799 0.0001108264200216 yes 64 4.67154314243528e-05 19 792097 SGTC_2688 kanamycin b 96.69 µM 3.8791867074233 0.000122833191316106 yes 65 5.24031448855205e-05 382 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2812 7970281 58.44 µM 3.86300235801508 0.000130357559023447 yes 66 5.60009631442205e-05 32 2233435 SGTC_2738 aclarubicin 5.55 µM 3.86181638638232 0.000130925597087596 yes 67 5.62735704019734e-05 8 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2376 9072922 81.32 µM 3.78917405836832 0.000170494960459375 yes 68 7.55744926686497e-05 34 17087968 SGTC_1263 0774-1208 64.8 µM 3.77975291778088 0.000176378179779393 yes 69 7.8492031019328e-05 54 906585 SGTC_2863 9028737 58.44 µM 3.722269162951 0.000216591813512931 yes 70 9.87201928574995e-05 8 6460917 SGTC_2130 NSC 7 2.4545 µM 3.68464022536923 0.000247389078529582 yes 71 0.000114512955883573 36 21448 SGTC_2201 6605497 169.863 µM 3.6532418231025 0.000276162986688495 yes 72 0.000129475072202424 14 670741 SGTC_2309 7664088 163.95 µM 3.62422645609153 0.000305496227963959 yes 73 0.000144913791368041 51 704922 SGTC_1165 k072-0275 30.3 µM 3.62192479305093 0.000307943084756317 yes 74 0.00014620957139944 50 6153523 YGL055W OLE1 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 3.61383152587706 0.000316692438117235 yes 75 0.000150852572998836 69 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1752 st044819 83.042 µM 3.61006764698806 0.000320839728845903 yes 76 0.000153058579778281 32 441209 YML126C ERG13 SGTC_2555 cholic acid 100 µM 3.58370447571178 0.000351335055198526 yes 77 0.000169377672419531 26 6708657 Influences liver metabolism. SGTC_1113 artemisinin 1.17947 µM 3.56646658422714 0.000372708602857439 yes 78 0.000180913461352302 22 2240 An anti-malaria and mitochondrial poison. SGTC_492 tmb-8 126 µM 3.56403961752995 0.000375813017204554 yes 79 0.000182595399836925 7 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1005 4092-0690 4.4 µM 3.54041379509669 0.000407313516539889 yes 80 0.000199750061165298 39 1529343 SGTC_262 fenpropimorph 62.5 µM 3.50907775097452 0.000452879391533034 yes 81 0.000224831716117631 39 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_36 0335-0881 14.2 µM 3.50207830740524 0.000463682775908546 yes 82 0.000230821957967423 145 23828853 SGTC_1084 voriconazole 435 nM 3.47529407994485 0.000507266351965633 yes 83 0.000255146800000222 41 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1435 4092-0789 56.7 µM 3.42438554188313 0.000600728048336622 yes 84 0.000308095673929488 26 2248285 SGTC_43 0570-0105 72.5 µM 3.4018536672738 0.000646970634159732 yes 85 0.000334652325345643 146 1114046 YDL195W SEC31 SGTC_1427 4048-4900 550 nM 3.401387447898 0.000647961261595075 yes 86 0.000335223652456625 45 24132586 SGTC_1304 1165-0502 251 µM 3.37423361648486 0.000708132707265601 yes 87 0.000370107595957416 90 767425 SGTC_1991 st073000 8.92 µM 3.36131927409689 0.00073852172440652 yes 88 0.000387855510633579 108 4301969 YIL048W NEO1 SGTC_1455 4262-0120 131 µM 3.28296957840671 0.000950144233224749 yes 89 0.000513598750294458 48 1529587 SGTC_2753 fluvastatin 17.09 µM 3.27524153477783 0.000973785536516585 yes 90 0.00052785834697098 62 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_712 r015-0009 80.6 µM 3.26550770308623 0.00100433116883872 no 91 0.000546340167357388 46 6813872 YLR060W FRS1 SGTC_1691 st019933 84.6 µM 3.25923300907433 0.00102448523469311 no 92 0.0005585693744635 34 6176082 SGTC_1359 1582-0056 520 nM 3.25040164543255 0.00105348021970976 no 93 0.000576210616198342 40 3661189 SGTC_1658 st012944 20 µM 3.23904875445295 0.00109185926303107 no 94 0.000599645355958785 99 24207260 SGTC_2155 5570423 76 µM 3.21757037251568 0.00116799421097841 no 95 0.000646406540120796 29 797402 SGTC_574 1315-0397 40 µM 3.20132947091999 0.00122875843764578 no 96 0.000683975095535553 80 6794277 SGTC_174 3553-0389 74.3 µM 3.18143589948638 0.00130712566493538 no 97 0.000732734744702525 45 738071 SGTC_418 lividomycin a 100 µM 3.16680952545055 0.00136762976089284 no 98 0.000770606154920157 38 72394 An antibiotic. SGTC_2389 9091542 195.52 µM 3.15836182978011 0.00140372985486397 no 99 0.000793292498317387 73 3626624 YOL127W RPL25 SGTC_2910 7948405 25.97 µM 3.15627994021084 0.0014127591735491 no 100 0.000798977075260764 49 2971328 SGTC_1239 0337-0584 35.4 µM 3.12561963249654 0.00155202207895284 no 101 0.000887154421859281 98 914301 YML130C ERO1 SGTC_14 0354-0009 295 µM 3.07954329758032 0.00178494711534832 no 102 0.00103659116774341 63 1713507 SGTC_2766 oltipraz 83.91 µM 3.07646824906526 0.00180157031726747 no 103 0.00104734305171764 62 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1160 4092-0570 10.5 µM 3.06394936155885 0.00187070874150581 no 104 0.00109217940281716 81 4994975 SGTC_1114 scopoletin 1.73284 µM 3.05811152542307 0.00190376680713747 no 105 0.00111368332072073 42 5280460 A coumarin with genotoxic properties. SGTC_831 k061-1017 217 µM 3.01758564486523 0.00214827695561361 no 106 0.00127398515518793 124 1240153 SGTC_553 k007-0256 45.7 µM 3.0152811581907 0.00216300114000284 no 107 0.00128370569599721 76 6287000 SGTC_2531 methyl deoxycholate 70.07 µM 3.0019247731366 0.00225015634085967 no 108 0.00134139231511647 69 16667744 Haematoxylin. SGTC_800 3448-7362 155 µM 3.00057146824274 0.00225916233449612 no 109 0.00134736754090627 273 15991913 SGTC_3308 9128332 17.569 µM 2.98983862463256 0.00233175194744656 no 110 0.0013956243484397 143 17332805 YDL196W YDL196W SGTC_2540 epiandrosterone 100 µM 2.97760039785243 0.00241709500244128 no 111 0.0014525723954636 128 441302 A steroid. SGTC_1066 ketoconazole 628 nM 2.96940893980543 0.00247578651018129 no 112 0.00149186614933725 62 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2725 haloperidol 53.21 µM 2.96206264258967 0.00252951549141933 no 113 0.00152792802710672 88 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_256 clotrimazole 625 nM 2.96154806604796 0.00253331819042841 no 114 0.00153048355902055 82 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2545 solidagenone 89.61 µM 2.95924394424233 0.0025504090095003 no 115 0.00154197434871153 11 6708572 An anti ulcer agent SGTC_1171 0368-0077 21.4 µM 2.95337173620414 0.00259443835394771 no 116 0.00157161600154668 54 3239779 SGTC_2384 9036245 200 µM 2.94747242623768 0.00263936135524777 no 117 0.00160191661866112 80 6462766 SGTC_2867 9039098 71.43 µM 2.90451859189316 0.0029882101783629 no 118 0.00183909178748165 97 6463460 SGTC_2131 toluylene red 5.2905 µM 2.90446405325178 0.00298867834828798 no 119 0.00183941222627694 79 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_3179 9107801 49.47 µM 2.89409398794534 0.00307890725845398 no 120 0.00190127161151672 51 4818259 SGTC_513 4245-1575 41.7 µM 2.8926356840188 0.00309179066098028 no 121 0.00191012067319375 207 719745 SGTC_2767 sibutramine 71.45 µM 2.87551941644811 0.00324667405771126 no 122 0.00201681668130488 69 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1820 st053765 18.6 µM 2.86908713835497 0.00330666012822008 no 123 0.00205829185203487 76 3690829 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 2.84699876003668 0.00352031282796606 no 124 0.00220667671396795 54 17037758 SGTC_288 1315-0019 35.1 µM 2.8401243481153 0.003589291394246 no 125 0.00225479756821867 85 6811474 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 2.83090298421491 0.00368372414509517 no 126 0.00232083988954782 75 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_134 0269-0018 6.916 µM 2.81242363466033 0.00387970034875127 no 127 0.00245848486806524 214 4378915 SGTC_907 3448-6986 75.5 µM 2.80807969819164 0.00392710346459902 no 128 0.00249189455587145 95 590582 SGTC_2663 amphotericin b 100 µM 2.78980219037487 0.00413229048234344 no 129 0.00263701265489922 52 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_216 k038-0035 28.382 µM 2.78343312781188 0.00420601335903187 no 130 0.00268934745196916 99 4444231 YPR107C YTH1 SGTC_2186 6124449 200 µM 2.77830238411851 0.00426625568148224 no 131 0.0027321870135302 79 3834182 YLR033W RSC58 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 2.77354190615401 0.00432283929980504 no 132 0.00277248491019646 87 6708514 SGTC_1055 3448-0672 86 µM 2.75978010904325 0.00449020490854263 no 133 0.00289201392193817 102 748378 SGTC_2792 7535235 81.82 µM 2.742161210773 0.00471291397863362 no 134 0.00305181887040216 94 1281891 SGTC_568 1193-0097 7.48 µM 2.73260717137445 0.00483775559042918 no 135 0.00314176126231136 248 3646150 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 2.72724975762193 0.00490904289235111 no 136 0.00319323393819612 92 279621 SGTC_1159 4092-0538 61.2 µM 2.71053231027154 0.00513754552145919 no 137 0.00335876516840084 93 717301 SGTC_1447 4239-0816 81.9 µM 2.69578128776169 0.00534698183381367 no 138 0.003511187930477 99 1341554 SGTC_3157 9099274 49.47 µM 2.68923295089497 0.00544236439329961 no 139 0.00358082114836344 63 17217662 SGTC_163 TUB2.036 7.546 µM 2.68705279606595 0.00547445425281208 no 140 0.00360427788713966 236 15992207 YJR013W GPI14 SGTC_2519 cryptotanshinone 88.04 µM 2.65647544599539 0.00594257288762337 no 141 0.00394811004889547 65 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2124 5246320 200 µM 2.65549166344822 0.00595820619778919 no 142 0.0039596445457708 99 579342 SGTC_1800 st050079 29.0735 µM 2.64664468866643 0.00610044022734346 no 143 0.00406473597603301 287 3645560 SGTC_637 1181-0519 7.26 µM 2.62390171959409 0.0064799808128383 no 144 0.00434644324335932 207 6252091 YGR060W ERG25 SGTC_602 3130-1533 38.1 µM 2.62167061454514 0.00651831623076635 no 145 0.0043749976515436 103 720941 SGTC_178 4092-0806 87.505 µM 2.6209230642869 0.00653120562106414 no 146 0.00438460246698736 214 2169044 SGTC_2974 9094440 9.66 µM 2.6010742708248 0.00688178878955752 no 147 0.0046466165981892 139 25236134 SGTC_2861 9024595 19.48 µM 2.58861532357637 0.00711024404890689 no 148 0.00481813371782686 25 16482810 SGTC_346 4513-0042 7.16 µM 2.58589320137206 0.00716104031934188 no 149 0.00485635100636146 119 2827372 SGTC_2938 9059746 27.26 µM 2.56736530319062 0.00751536462376724 no 150 0.00512372966599184 131 6471769 SGTC_408 cantharidin 100 µM 2.55934373244089 0.00767349825160572 no 151 0.00524349960720279 108 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_67 0335-0847 266 µM 2.54462256036478 0.00797133816511133 no 152 0.00546979569552112 260 4552207 YOR254C SEC63 SGTC_1669 st015249 58.4 µM 2.54324586187368 0.00799970464456339 no 153 0.0054913959431232 69 722793 SGTC_268 camptothecin 39.6153 µM 2.5422123871073 0.0080210573772339 no 154 0.00550766081972039 219 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_778 3456-2434 196 µM 2.54182247353344 0.0080291264317031 no 155 0.00551380841074918 183 5539063 SGTC_646 4092-0839 27.3 µM 2.54005740691985 0.00806574287967188 no 156 0.00554171374870872 99 877796 SGTC_158 k038-0087 26.446 µM 2.5369909752753 0.00812970533408646 no 157 0.00559049182224665 260 X158 SGTC_2594 a-mangostin 100 µM 2.51182678592136 0.00867165818697263 no 158 0.00600540127961754 122 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_366 0181-0206 4.31 µM 2.50399382339787 0.00884669938314484 no 159 0.00614000889779682 159 274874 SGTC_1721 st082152 9.2685 µM 2.47406699714898 0.00954430025552371 no 160 0.00667923215297343 116 5296051 SGTC_2651 TUB2.036 5 µM 2.42406511688694 0.0108174109604869 no 161 0.00767392660881291 340 15992207 YFL037W TUB2 SGTC_747 3448-8087 38.7 µM 2.40595484069065 0.0113137043984811 no 162 0.00806512925607429 149 5168703 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 2.3986270880921 0.0115200687674875 no 163 0.00822833234130092 157 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_865 0488-0499 301 µM 2.38599267588103 0.0118835621381624 no 164 0.0085165451404281 113 9634651 SGTC_217 ketoconazole 989 nM 2.38389683732076 0.0119448120109417 no 165 0.00856520189302277 132 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2369 9071472 200 µM 2.37906403558332 0.0120870928762673 no 166 0.00867833025566726 144 17296037 SGTC_2950 9072895 21.46 µM 2.35861904537096 0.0127053817002182 no 167 0.00917153767316331 197 17332245 SGTC_165 k038-0023 64.381 µM 2.35664161144209 0.0127666090859363 no 168 0.00922051743134406 228 46368543 SGTC_1024 4507-0395 26 µM 2.35361194273177 0.0128609119966537 no 169 0.009296004449279 149 4201836 SGTC_2076 5212012 200 µM 2.35327937464707 0.0128713002743194 no 170 0.00930432353915263 59 604802 SGTC_2965 9082772 38.63 µM 2.35068604817861 0.0129525560581909 no 171 0.00936941856124274 161 16459634 SGTC_1985 st071382 65.5 µM 2.34075787262166 0.013267744749489 no 172 0.00962232161034203 134 6123237 SGTC_1019 4262-0212 3.4 µM 2.33269214245902 0.0135286632956188 no 173 0.00983215444700319 219 4677213 SGTC_562 3772-2733 112 µM 2.33254449795007 0.013533480441629 no 174 0.0098360324284585 216 2876874 YIL048W NEO1 SGTC_2520 obtusaquinone 4.71 µM 2.32019121314609 0.0139418061752394 no 175 0.0101652678635481 123 5967872 SGTC_2149 5554786 194.827 µM 2.31909279868362 0.0139786221101023 no 176 0.0101950025777152 188 745063 YPR165W RHO1 SGTC_228 caffeine 993.056 µM 2.31554641936965 0.0140980599857484 no 177 0.0102915236279843 93 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3356 9151811 4.48 µM 2.31486826423539 0.0141209993404145 no 178 0.0103100713152569 136 1859254 YPR165W RHO1 SGTC_3062 9077494 49.47 µM 2.30280922594686 0.0145343130086444 no 179 0.0106447896060188 153 16459633 SGTC_2948 9070189 9.45 µM 2.30145889367924 0.0145812364020648 no 180 0.0106828531565065 158 6473636 YDL196W YDL196W SGTC_340 k038-0059 454 µM 2.29694345462152 0.0147390937697448 no 181 0.0108109978180393 166 23733424 SGTC_1400 3771-8998 51.5 µM 2.28782406721841 0.0150623894859074 no 182 0.0110738843409772 80 670767 SGTC_2246 7293507 91.5585 µM 2.28617029931877 0.0151216661836929 no 183 0.0111221487989386 166 887656 SGTC_1477 0139-0234 16 µM 2.28525318112595 0.015154625156666 no 184 0.0111489932434133 124 620880 SGTC_61 0978-8327 98.565 µM 2.28475011610935 0.015172730275641 no 185 0.011163742086776 160 6150059 YHR072W ERG7 SGTC_2735 sertaconazole 140 nM 2.27791547723795 0.0154205535225052 no 186 0.0113658069797385 82 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2993 9054257 71.4286 µM 2.27666858668038 0.0154661384961067 no 187 0.0114030118776093 216 6470217 YGL055W OLE1 SGTC_1803 st050068 52.4 µM 2.27503915429077 0.0155258831045195 no 188 0.0114517905665373 401 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1661 st013063 9.66 µM 2.26952056592549 0.0157297008617836 no 189 0.0116183440107305 181 721395 SGTC_218 alverine citrate 93.75 µM 2.26773865008691 0.0157960005910307 no 190 0.0116725703223305 129 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2833 9001315 45.46 µM 2.26277191032342 0.0159820644348315 no 191 0.0118248766629755 206 2989378 SGTC_628 1636-0253 16 µM 2.25367986958269 0.0163275400556522 no 192 0.0121081573316034 192 4456143 SGTC_156 3474-0145 5.642 µM 2.25068318238215 0.0164427995284002 no 193 0.0122028053431139 199 2265471 SGTC_2027 5150920 200 µM 2.24995603864415 0.0164708719373089 no 194 0.012225868042183 131 786715 SGTC_141 0443-0274 32.331 µM 2.2491652155679 0.016501449343786 no 195 0.0122509933178176 267 1627241 SGTC_2790 5423970 71.43 µM 2.24115660299791 0.0168138520105079 no 196 0.0125079663956291 221 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_953 1188-0045 9.7 µM 2.23717222701634 0.0169711512033892 no 197 0.0126375428995081 181 6144426 SGTC_1861 st057647 17.4 µM 2.23358964894865 0.0171136603420799 no 198 0.0127550428116919 167 688668 SGTC_2096 5468907 200 µM 2.22503742542797 0.0174579941074666 no 199 0.0130393629157401 142 759785 SGTC_726 3448-4391 34.2 µM 2.21515665594031 0.017863167231832 no 200 0.0133746568908972 177 1356692 SGTC_2208 7283366 200 µM 2.20872834232136 0.0181310524376087 no 201 0.0135967709155669 138 898663 SGTC_1731 st035964 63 µM 2.20587223708303 0.0182511683083281 no 202 0.0136964733076389 179 6739575 SGTC_2752 diclazuril 33.15 µM 2.20349416339032 0.0183516968526058 no 203 0.0137799689493925 331 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1276 0871-0068 94.2 µM 2.20035404686183 0.0184851616377299 no 204 0.0138908927356014 143 3414906 SGTC_2046 4110841 106 µM 2.19505444545172 0.0187122860058956 no 205 0.0140798462185835 155 44119630 YMR134W ERG29 SGTC_1247 0448-0043 5.84 µM 2.18447450488662 0.0191728187453204 no 206 0.0144636993564874 239 3089013 YGL099W LSG1 SGTC_28 pentachloropyridine N-oxide 1.606 µM 2.18325577190381 0.0192264825317352 no 207 0.0145084898217636 223 140250 A respiratory chain inhibitor. SGTC_1346 1488-2224 62.4 µM 2.17496555508035 0.0195949194609414 no 208 0.0148163488451586 146 3722427 SGTC_1188 1403-0014 4.57 µM 2.16503951312145 0.0200439269368693 no 209 0.0151923297198918 252 9614867 SGTC_2101 5377231 179.231 µM 2.16441618625181 0.0200724122168638 no 210 0.0152162113427817 139 2844213 SGTC_2129 girgensonine 121.053 µM 2.16018233638248 0.0202668040964503 no 211 0.0153792785054743 207 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1500 4488-1866 171 µM 2.15770833621481 0.0203811317652139 no 212 0.0154752577090546 172 2900003 SGTC_1124 fisetin 1.16336 µM 2.15649541242039 0.0204373823854587 no 213 0.0155225008049922 191 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2954 9074818 52.69 µM 2.15413573122367 0.0205471920795244 no 214 0.0156147645720543 183 16648742 SGTC_1720 st037298 9.481 µM 2.15379884175987 0.0205629102084922 no 215 0.0156279752947375 198 597396 SGTC_841 0251-0215 91.2 µM 2.14895491677932 0.0207900399750561 no 216 0.0158189869394471 238 3888614 SGTC_579 4491-1009 110 µM 2.13780163397738 0.0213211005038951 no 217 0.0162664231739316 242 1271041 SGTC_1694 st024011 44.9 µM 2.13713463275656 0.021353219846708 no 218 0.0162935214035654 192 2787533 SGTC_791 1348-1292 225 µM 2.13605081932124 0.0214054979668058 no 219 0.0163376359007312 254 5437054 SGTC_3288 9119690 36.221 µM 2.13579489313197 0.02141785843638 no 220 0.0163480677893933 165 17595618 YKL019W RAM2 SGTC_577 r071-0003 38.6 µM 2.12860720229087 0.0217674748944698 no 221 0.0166433860673863 297 4568517 YMR134W ERG29 SGTC_1783 st039459 87.517 µM 2.12548143714482 0.0219210125728744 no 222 0.0167732306882474 207 729761 SGTC_432 NS 1619 61.3 µM 2.10866279813546 0.0227629277867526 no 223 0.0174868490731627 205 4552 A K+/calcium channel activator. SGTC_720 r052-1644 49.9 µM 2.10650252652189 0.0228730171033802 no 224 0.0175803619396755 162 1422863 YOR257W CDC31 SGTC_1893 st059353 36.1 µM 2.10586400741916 0.0229056423514056 no 225 0.0176080834634019 193 3112488 SGTC_1216 1165-0504 9.65 µM 2.09779903453592 0.0233211093269176 no 226 0.0179614509260694 185 6304004 SGTC_2747 doxorubicin 7.63 µM 2.0825622298475 0.0241233512809072 no 227 0.0186455725111457 82 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_352 k048-0007 5.11 µM 2.08169129358635 0.0241698994666225 no 228 0.0186853381996079 257 6811911 SGTC_2038 4100038 30.985 µM 2.07189641733342 0.02469861303328 no 229 0.0191375510822273 228 3596803 SGTC_3350 9150499 3.57 µM 2.06106423121018 0.0252945835959874 no 230 0.0196484563401595 262 4910996 YPR165W RHO1 SGTC_2337 9009472 200 µM 2.05462624704793 0.0256544666307537 no 231 0.0199575592585941 255 5742383 SGTC_3324 9138759 60.749 µM 2.04653088408765 0.0261130712489677 no 232 0.0203520835422623 192 45595710 SGTC_2612 dictamnine 15.46 µM 2.04148925071836 0.0264021308368222 no 233 0.0206011106219927 234 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_837 0091-0265 12.5 µM 2.0406996169352 0.0264476454257459 no 234 0.020640346735181 214 759367 SGTC_689 0833-0039 98 µM 2.03471161480533 0.0267949328383215 no 235 0.0209399494128287 200 5374726 SGTC_842 0271-0008 11.1 µM 2.014505405184 0.0279950581260759 no 236 0.0219782489774614 212 1221709 SGTC_745 0469-0705 296 µM 2.01326281514671 0.0280702987064299 no 237 0.0220434940338228 245 3486736 SGTC_2825 7998094 58.44 µM 2.01086312109822 0.0282160801905046 no 238 0.022169958331027 217 2987815 SGTC_718 1130-0073 349 µM 2.01030992669889 0.0282497760070526 no 239 0.0221991984556271 221 6740020 SGTC_960 1222-0186 7.7 µM 2.006074189813 0.0285088920790292 no 240 0.0224241665644468 225 3126296 SGTC_642 0335-0876 158 µM 1.9995976851378 0.02890890500208 no 241 0.0227718620570193 246 6812350 SGTC_882 0843-0131 351 µM 1.99736287215239 0.029048013434165 no 242 0.0228928890019129 220 5425421 SGTC_946 3434-1334 87.4 µM 1.99657748411464 0.0290970326852211 no 243 0.0229355504009973 216 4047976 SGTC_1501 4491-0275 38.4 µM 1.99391288527219 0.029263853508096 no 244 0.0230807877759134 184 5104718 SGTC_1001 4048-4355 44.4 µM 1.99133293772128 0.029426130770114 no 245 0.0232221483099054 217 21824233 SGTC_2430 5571206 200 µM 1.9859889382102 0.0297646425294728 no 246 0.0235172760982553 261 1731771 SGTC_912 3474-0017 2.18 µM 1.98487584004665 0.0298355559594428 no 247 0.0235791434915959 226 3360550 SGTC_1253 0550-0034 176 µM 1.9749967566708 0.0304710963212348 no 248 0.02413425803638 222 5969915 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.96894327123209 0.0308660411772447 no 249 0.0244798029048579 201 756377 SGTC_2464 5717415 7.67 µM 1.96281306865067 0.0312702998450928 no 250 0.0248339493585997 229 5285744 SGTC_2748 diazoxide 86.69 µM 1.96032559179806 0.0314355817033703 no 251 0.0249788733265384 165 3019 A potassium channel activatior. SGTC_924 2046-0044 21.3 µM 1.95130290604374 0.0320411714671238 no 252 0.0255105117940632 217 3623589 SGTC_1320 1313-0481 95.3 µM 1.94387172672162 0.0325471468023518 no 253 0.0259554607480849 216 6813365 YLR208W SEC13 SGTC_2932 9016711 44.54 µM 1.9431073174502 0.0325995658138136 no 254 0.0260015965431572 284 7117328 SGTC_725 1497-0963 19 µM 1.9415952048317 0.0327034633384531 no 255 0.0260930619247306 205 3549977 SGTC_580 1123-0028 41 µM 1.9372795301815 0.0330014966788783 no 256 0.0263555915410696 318 1677248 YPR107C YTH1 SGTC_2543 pimpinellin 60.67 µM 1.93648508758913 0.033056602759111 no 257 0.0264041586109603 228 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2067 5224629 34.075 µM 1.93595811212754 0.0330931979366075 no 258 0.026436415719595 253 2835000 SGTC_945 3381-0768 11.3 µM 1.93429433210075 0.0332089562520961 no 259 0.0265384748599658 262 1126236 YIL048W NEO1 SGTC_3000 9075062 71.4286 µM 1.93396861215678 0.0332316573725443 no 260 0.0265584935661923 223 17057871 SGTC_1296 1068-0102 11.9 µM 1.93258385648035 0.033328310938172 no 261 0.0266437413553828 223 767053 SGTC_1646 st011709 75.6 µM 1.92216136673978 0.0340632346106881 no 262 0.0272927281619332 192 5757843 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.92057116206686 0.0341765281090214 no 263 0.0273928968455897 208 2724278 An inhibitor of dopamine biosynthesis. SGTC_1324 1418-0026 34.4 µM 1.91998959259544 0.0342180390785355 no 264 0.0274296070062897 256 1372513 SGTC_2326 6164455 177.58 µM 1.91864643669987 0.0343140685850066 no 265 0.0275145472605033 233 2888790 SGTC_54 0159-0055 9 µM 1.91137064235294 0.0348381113029072 no 266 0.02797848333461 239 3319099 SGTC_653 0203-0016 55.2 µM 1.90680187606119 0.0351705245720066 no 267 0.0282731241630266 237 295302 SGTC_1339 1486-1321 22.7 µM 1.90337846590224 0.0354213060565039 no 268 0.0284955894168338 255 3469382 SGTC_221 trifluoperazine 10.304 µM 1.90333992842447 0.0354241374391235 no 269 0.0284981019828964 468 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1830 st055982 50.3 µM 1.89826932361192 0.0357983011434507 no 270 0.0288303064137103 260 455313 An antimicrobial agent. SGTC_940 3232-1287 54.8 µM 1.89767035350228 0.0358427126716893 no 271 0.0288697601379983 247 1585493 YIL048W NEO1 SGTC_281 1672-3440 14.9 µM 1.89754784049457 0.0358518021393066 no 272 0.0288778355067635 226 6833000 SGTC_2692 st077426 47.7 µM 1.8934544328154 0.036156586990199 no 273 0.0291487312601674 263 25238571 SGTC_2095 5432005 200 µM 1.88809314632464 0.0365589806094941 no 274 0.0295067234003208 219 783734 SGTC_3199 9111318 49.47 µM 1.88631299753404 0.0366933979294604 no 275 0.0296263944011368 252 8548020 SGTC_2525 harmine 47.85 µM 1.88604696211575 0.0367135206837687 no 276 0.0296443132553694 186 5280953 A monoamine oxidase inhibitor SGTC_2322 7413319 38.22 µM 1.88516079025865 0.0367806152904001 no 277 0.0297040663787085 464 1840400 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.88412604768846 0.0368590854772747 no 278 0.0297739638255436 326 551469 SGTC_2215 7188065 200 µM 1.87882582832018 0.0372631791798906 no 279 0.0301341395645045 174 940217 SGTC_2269 7935389 174.42 µM 1.87364134213673 0.0376619439097095 no 280 0.0304899378922398 258 97605 SGTC_279 1273-0055 2.93 µM 1.87216214044369 0.0377763533078215 no 281 0.0305920875584692 280 2847562 SGTC_1198 1612-1005 86.7 µM 1.86689966678239 0.0381856830390976 no 282 0.0309578002097142 244 6998509 SGTC_2452 5863136 48.41 µM 1.86251710496464 0.0385293248497935 no 283 0.0312651183471529 263 2184096 SGTC_249 wiskostatin 11.211 µM 1.85779647527437 0.0389022900581726 no 284 0.0315989609349389 221 2775510 A n-wasp and actin depolymerizer. SGTC_18 0111-0177 500 nM 1.85569792039385 0.0390690330819658 no 285 0.0317483137020628 381 721752 SGTC_200 k038-0079 37.545 µM 1.83765691602448 0.0405266271567217 no 286 0.0330564881269281 264 3436683 SGTC_505 gw-5074 63.9 µM 1.834995081307 0.0407453761103146 no 287 0.0332532091282207 285 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1034 k072-0165 12.7 µM 1.83213081516094 0.0409818300032184 no 288 0.0334659666631132 305 5835461 SGTC_2700 st077718 96.8 µM 1.81955188195032 0.0420334682298724 no 289 0.034413637538022 226 904970 SGTC_744 1594-0068 283 µM 1.80107466173705 0.0436177224143521 no 290 0.0358455564235172 336 668392 SGTC_1836 st055642 81 µM 1.79522270596083 0.0441294051970054 no 291 0.0363091121066401 311 8571 SGTC_2558 carylophyllene oxide 100 µM 1.78359501736973 0.0451604634557431 no 292 0.0372447479221093 293 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2605 digitonin 300 nM 1.78034696529405 0.0454519148209124 no 293 0.0375095977161617 343 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_208 k072-0098 12.366 µM 1.77868290053418 0.0456018181716345 no 294 0.0376458820723638 374 5948901 SGTC_780 0109-0199 192 µM 1.77846453345212 0.0456215187236 no 295 0.0376637959687672 331 610414 SGTC_44 0929-0055 61.211 µM 1.77798536631104 0.0456647720086684 no 296 0.0377031291699241 274 1379590 SGTC_1680 diphenhydramine 100 µM 1.76234819752564 0.0470944849589824 no 297 0.0390052426262863 317 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1088 bifonazole 369 nM 1.75390845315132 0.0478809183946211 no 298 0.0397230974607585 271 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1377 2944-0135 198 µM 1.75215730500878 0.0480454038461652 no 299 0.0398733814141741 334 1894137 SGTC_275 trichlorophene 5.69 µM 1.74871497170635 0.0483700604825518 no 300 0.0401701503833903 527 62616 SGTC_1997 st073024 93.8 µM 1.74322229428685 0.0488917223100501 no 301 0.0406473963035552 280 686268 SGTC_1941 st076221 61.8 µM 1.73936629562505 0.0492606206409095 no 302 0.0409851764142185 390 2828568 SGTC_1460 k062-0059 9.15 µM 1.73897925943275 0.0492977702989232 no 303 0.0410192056051541 276 1373085 SGTC_90 0870-0863 4.608 µM 1.73834750070771 0.0493584576969471 no 304 0.0410748006392765 337 1738164 SGTC_2744 captopril 92.04 µM 1.73550727964518 0.0496320294607431 no 305 0.0413254966098646 218 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_451 chloral hydrate 100 µM 1.73151725070642 0.050018393697842 no 306 0.0416797754095047 395 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1327 1436-0082 2.18 µM 1.72943197429434 0.0502212682434489 no 307 0.0418659057778182 299 15992205 SGTC_2111 5486399 200 µM 1.72912876727403 0.0502508215063622 no 308 0.0418930257918806 368 689674 SGTC_846 0335-0850 148 µM 1.72842746335188 0.0503192299560632 no 309 0.0419558076387917 271 6819598 SGTC_1215 3852-0577 11.2 µM 1.72080105815104 0.0510679463991979 no 310 0.0426434651773291 339 2884876 SGTC_1196 1588-0294 184 µM 1.71174144767373 0.0519688591234634 no 311 0.0434721633626241 296 6144269 SGTC_3180 9109287 49.47 µM 1.71162503064929 0.0519805176041721 no 312 0.0434828962272542 288 18891271 SGTC_367 0335-0881 7.1 µM 1.71108804779632 0.0520343201813199 no 313 0.0435324301157122 367 23828853 SGTC_2485 5633444 17.78 µM 1.70698767746915 0.052446613646574 no 314 0.0439121713949623 351 5724239 SGTC_3100 9120536 49.47 µM 1.70490522891623 0.0526569952190428 no 315 0.0441060505069275 211 16421196 SGTC_1700 st030840 7.9285 µM 1.70484712286575 0.0526628750340591 no 316 0.0441114701495528 326 5499307 SGTC_634 1611-4317 11.2 µM 1.70301269760433 0.0528487705440507 no 317 0.044282846097034 350 2843522 SGTC_2066 5222451 176 µM 1.70264216291615 0.0528863826056192 no 318 0.0443175273026296 394 2281147 SGTC_2518 prenyletin 46.28 µM 1.69905634433281 0.0532514681416982 no 319 0.0446542839152778 213 3873459 A coumarin with calcium channel inhibitory activity. SGTC_641 4092-0595 30 µM 1.69691074121358 0.0534708735165877 no 320 0.0448567684958976 331 786260 SGTC_989 1501-0895 10.3 µM 1.69685957270066 0.0534761146449741 no 321 0.04486160637397 283 2830112 SGTC_3009 9080819 71.4286 µM 1.69218090249195 0.0539570678157476 no 322 0.0453057433240268 305 17027216 SGTC_8 0354-0001 70 µM 1.68945822920594 0.0542385227509098 no 323 0.045565825109533 437 4993152 SGTC_869 0564-0080 44.1 µM 1.68867543734999 0.0543196581022452 no 324 0.0456408226232232 369 6843321 SGTC_730 1436-0052 41.2 µM 1.6864832264568 0.0545473889517148 no 325 0.0458513815792261 277 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1009 4106-0057 9.87 µM 1.68502931435539 0.0546988399521777 no 326 0.0459914579431806 340 2928005 SGTC_862 0452-0056 10.2 µM 1.68376742111818 0.054830558066572 no 327 0.0461133128562032 300 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2362 9071156 126 µM 1.68267356339214 0.0549449391501519 no 328 0.0462191510940675 328 653133 SGTC_263 alizarin 107.927 µM 1.68086901425851 0.0551340469176473 no 329 0.0463941798767754 428 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_49 0717-0965 32.132 µM 1.680206521016 0.0552036018068957 no 330 0.0464585705156689 340 5889349 YGL099W LSG1 SGTC_936 3005-4620 401 µM 1.67455833446033 0.0557994205181822 no 331 0.0470104599809196 367 777207 SGTC_1101 ebselen 5.29 µM 1.67378566536072 0.0558813212894375 no 332 0.0470863652765402 339 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_797 k781-0471 270 µM 1.67192909134723 0.0560785006753321 no 333 0.0472691527189684 343 23738129 SGTC_1023 4482-3888 16 µM 1.67125202762896 0.0561505453239169 no 334 0.0473359538083703 319 3303168 SGTC_1687 st020778 55.3625 µM 1.66535094348381 0.0567815589828307 no 335 0.04792138022396 521 4259299 SGTC_768 0384-0033 77.3 µM 1.66478663215242 0.0568421932572642 no 336 0.0479776659270561 419 3965305 YMR134W ERG29 SGTC_830 4076-0286 57.8 µM 1.66474946778132 0.0568461882935609 no 337 0.0479813746428629 537 6866659 SGTC_2595 hexamethylquercetagetin 100 µM 1.66145116794459 0.057201625176551 no 338 0.0483114342768914 322 386331 SGTC_1306 1185-0270 9.02 µM 1.65965495241569 0.0573959262973956 no 339 0.0484919432911165 365 1548076 SGTC_1534 6-azauridine 81.6 µM 1.65842346847227 0.0575294387685153 no 340 0.0486160114652445 398 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_3039 9090270 49.47 µM 1.65416389141624 0.0579931293339022 no 341 0.0490471086534397 287 17173750 SGTC_3136 9095672 49.47 µM 1.65267326884218 0.0581560881060834 no 342 0.0491986887648474 290 17217380 SGTC_2360 9040895 200 µM 1.65233347657486 0.0581932853950756 no 343 0.0492332942510116 334 4914414 SGTC_2999 9069765 71.4286 µM 1.64801570421694 0.0586675843768703 no 344 0.0496747243168536 350 2097066 SGTC_552 k242-0005 476 µM 1.64561578624379 0.0589325197877317 no 345 0.0499214434720361 302 4088318 SGTC_2204 7233102 200 µM 1.6425097858615 0.0592767946689418 no 346 0.0502421999039008 278 2172480 SGTC_2339 9000433 200 µM 1.64104810372332 0.0594393550021812 no 347 0.0503937150761617 324 2988954 SGTC_1746 st038117 42 µM 1.63965051723552 0.0595951135798863 no 348 0.0505389264983966 372 2898218 SGTC_1142 3253-1408 9.78 µM 1.63769451833763 0.0598136431318614 no 349 0.0507427173462556 336 256655 SGTC_2289 7946404 165.07 µM 1.63075019683029 0.0605945553961719 no 350 0.0514715200253604 466 1246120 YPR165W RHO1 SGTC_2638 epoxomicin 18 µM 1.6267639021584 0.0610464176205633 no 351 0.0518936255000265 374 9915668 A protesome inhibitor. SGTC_2439 5492030 7.2 µM 1.62319865912601 0.0614527793363657 no 352 0.052273472202491 329 5722370 SGTC_3033 9090887 49.47 µM 1.62295689527963 0.0614804115740389 no 353 0.0522993098373279 397 19325384 SGTC_3342 9147791 14.508 µM 1.62031839164347 0.0617826088293415 no 354 0.0525819500759021 349 1838168 SGTC_3155 9099265 49.47 µM 1.60996350923629 0.0629798075407285 no 355 0.0537029114058964 331 25236499 SGTC_15 0266-0086 27.098 µM 1.60607735461615 0.0634337480033214 no 356 0.0541284573964365 461 1712902 YIL048W NEO1 SGTC_2291 7917025 104.35 µM 1.60326825685992 0.063763460550078 no 357 0.0544377207545327 405 2964612 SGTC_2973 9094665 17.96 µM 1.60070494331633 0.064065486479823 no 358 0.0547211428856555 419 25237061 YIL048W NEO1 SGTC_2940 9060638 45.86 µM 1.59830813111493 0.0643488992846529 no 359 0.0549872093497374 388 4027022 SGTC_2506 ethyl hematommate 54.16 µM 1.59783396073392 0.0644050831717301 no 360 0.0550399672040476 314 3940691 An allergen. SGTC_1989 st071868 50.2 µM 1.58979180541236 0.0653638047752855 no 361 0.0559408708092462 392 16414057 SGTC_285 1486-1325 46 µM 1.58566771313463 0.065859721456222 no 362 0.0564073534794404 394 22310230 SGTC_2075 5212009 200 µM 1.57974752684409 0.0665767073323301 no 363 0.0570823483925894 320 780898 SGTC_3058 9093861 49.47 µM 1.57885670148589 0.066685114992755 no 364 0.0571844646899559 387 17217477 SGTC_3071 9117417 49.47 µM 1.573997443349 0.067278861708262 no 365 0.0577440202518281 287 45595590 YGL055W OLE1 SGTC_3216 9129716 49.47 µM 1.56945845118788 0.0678371595543799 no 366 0.0582705767497511 367 8056934 SGTC_2477 5967686 25.23 µM 1.56869144374135 0.0679318541701595 no 367 0.0583599266314166 391 776118 SGTC_1186 1319-0216 26 µM 1.56126884008597 0.068853528482625 no 368 0.0592301662024878 420 4565136 SGTC_417 st075190 100 µM 1.55714963343769 0.0693691589448709 no 369 0.0597174816352555 396 222757 SGTC_3314 9135860 59.4275 µM 1.55617060281307 0.0694921475531927 no 370 0.059833764892285 394 25252478 SGTC_2420 aureobasidin a 50 nM 1.55003925459498 0.070266207131277 no 371 0.0605660472406574 450 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1434 4073-0095 163 µM 1.54901574308909 0.0703960649429229 no 372 0.0606889678187024 392 24133745 SGTC_1638 st008370 60.6 µM 1.54658992593858 0.0707045768501099 no 373 0.0609810802356234 426 24207134 SGTC_2363 9053361 176 µM 1.54509993125895 0.0708945866463932 no 374 0.0611610468129128 415 6469797 YMR079W SEC14 SGTC_2488 5268135 45.7 µM 1.53828917780058 0.0717681177685658 no 375 0.0619889623254207 495 1270356 YLR208W SEC13 SGTC_1597 7-benzyloxygramine 47.5 µM 1.53767301844785 0.0718475503519484 no 376 0.0620642920027858 570 260807 SGTC_1044 1222-0021 1.78 µM 1.53464010608065 0.0722395232857876 no 377 0.0624361277102919 419 4306703 SGTC_1281 0884-0031 11.8 µM 1.53244175340262 0.0725246608756989 no 378 0.0627067303372382 441 1548255 SGTC_2662 daunorubicin 22.37 µM 1.52820256260938 0.0730769387001647 no 379 0.0632311263756213 352 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3246 9135460 32.98 µM 1.52656748045527 0.0732908136919389 no 380 0.0634342992963114 319 41446951 SGTC_1778 st046819 58.9 µM 1.52448331647236 0.0735641240739028 no 381 0.0636940106724748 463 671715 SGTC_2906 7926292 26.41 µM 1.52437085028612 0.0735788946494319 no 382 0.0637080487731635 420 2966319 SGTC_2685 mycophenolic acid 18.85 µM 1.52338201410556 0.0737088595765533 no 383 0.0638315795718153 345 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1086 cerivastatin 2.18 µM 1.5174753750487 0.074488839728114 no 384 0.0645733530618564 368 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2125 5246583 200 µM 1.51635084085594 0.0746380474668672 no 385 0.0647153311908875 491 835267 SGTC_2054 5233173 129 µM 1.51154742835128 0.0752779526690295 no 386 0.0653245171670101 482 6889 SGTC_676 falcarinol 140 µM 1.50990192847908 0.0754981234182309 no 387 0.0655342252694054 450 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_3151 9099821 49.47 µM 1.50848887987485 0.0756875831204387 no 388 0.0657147253039385 367 17174189 SGTC_2121 5257820 149.641 µM 1.50594507829411 0.0760295652876754 no 389 0.0660406365930612 443 791256 SGTC_3186 9110464 49.47 µM 1.50458911597631 0.0762123374103219 no 390 0.0662148731199016 403 17018021 SGTC_1478 0453-0656 35.7 µM 1.49806092894621 0.0770969646097854 no 391 0.0670587105254987 426 5258496 SGTC_3209 9113616 49.47 µM 1.49792539425807 0.0771154130952147 no 392 0.0670763175390551 459 16649353 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.49772621302301 0.0771425310027034 no 393 0.0671021992231069 406 6710655 SGTC_406 estrone 100 µM 1.49635068428157 0.0773300028219014 no 394 0.0672811468152555 423 5870 A steroid. SGTC_548 1436-0017 110 µM 1.49308022006422 0.0777771261681227 no 395 0.0677080947579141 519 9677137 SGTC_1071 trifluoperazine 6.31 µM 1.48769159702398 0.0785181110518827 no 396 0.0684161223266332 457 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1552 6-methylflavone 10.6 µM 1.48499059152603 0.0788915315536739 no 397 0.0687731582132331 360 689013 SGTC_287 k060-0039 29.6 µM 1.48467971513958 0.0789345971508184 no 398 0.0688143438312151 399 5861974 SGTC_2292 7671323 168.05 µM 1.48408657838177 0.0790168135760373 no 399 0.0688929767018834 448 937504 SGTC_1606 st000094 49.2 µM 1.47352695985305 0.0804913900436686 no 400 0.0703044999008725 445 1242210 SGTC_1863 st057641 20.1 µM 1.4709515235653 0.0808541652816874 no 401 0.0706521136085857 469 3921635 SGTC_2754 granisetron 64.02 µM 1.46871189309544 0.0811706412966087 no 402 0.0709554751336626 464 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2346 9031566 143.75 µM 1.46644562014129 0.0814918326237472 no 403 0.0712634628502518 414 4771086 SGTC_2377 9073351 62.6 µM 1.4662502398484 0.0815195680372062 no 404 0.0712900631164202 430 7337946 YHR072W ERG7 SGTC_3166 9102297 49.47 µM 1.46468257520155 0.081742365259458 no 405 0.0715037705599433 462 25237072 SGTC_1100 amiodarone 5.07 µM 1.45539226060814 0.0830721383212861 no 406 0.0727803488935516 484 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_416 estradiol valerate 100 µM 1.45364566179638 0.0833239451840723 no 407 0.0730222852118547 424 13791 A steroid. SGTC_1199 1638-0010 4.46 µM 1.45346698786581 0.0833497368911397 no 408 0.0730470695270493 484 3111136 SGTC_1403 3909-7815 62.9 µM 1.45149786533994 0.0836343787378377 no 409 0.0733206381099158 393 6615483 SGTC_1031 k035-0009 16 µM 1.44446107844768 0.0846575343015233 no 410 0.0743046602446697 495 5180959 SGTC_1670 st016595 4.04 µM 1.44363631052612 0.0847780683453304 no 411 0.0744206527083922 463 597879 SGTC_859 0439-0102 54.6 µM 1.44304837120755 0.0848640700816502 no 412 0.0745034227904914 483 610143 SGTC_3334 9142812 21.919 µM 1.43993397368752 0.0853207246098646 no 413 0.0749430400582188 457 45283678 SGTC_467 ro 31-8220 72.8 µM 1.43848649774391 0.085533589100167 no 414 0.0751480329079297 494 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1163 k060-0048 49.9 µM 1.43671572773657 0.0857945374724501 no 415 0.0753993920822989 493 6809982 SGTC_1977 st070720 65.3 µM 1.43405478981352 0.0861877847434677 no 416 0.075778314052815 414 682188 SGTC_871 0574-0004 149 µM 1.43287773133393 0.0863621660691029 no 417 0.0759463911118381 502 9551173 SGTC_949 1165-0505 146 µM 1.43092507098895 0.0866520345608143 no 418 0.0762258454259861 496 6244267 SGTC_1871 st057448 67.3 µM 1.42973188498233 0.0868295181914588 no 419 0.0763969926382074 486 691747 SGTC_2423 st077119 87.2 µM 1.42877449691689 0.0869721237257404 no 420 0.0765345289510977 451 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1470 k295-0292 231 µM 1.42867867724318 0.0869864059502031 no 421 0.0765483045614539 481 5045612 SGTC_708 3448-5400 146 µM 1.42224394594702 0.0879495369316011 no 422 0.0774777226083432 500 3462195 SGTC_2196 6573537 42.6665 µM 1.41992418631857 0.088298694683259 no 423 0.0778148768731693 421 2903087 SGTC_624 k048-0052 28 µM 1.41864653285244 0.088491440858944 no 424 0.0780010461806078 443 6835531 SGTC_1750 st081859 2.357 µM 1.41814290346527 0.0885675042147968 no 425 0.078074523761947 669 5291695 SGTC_1465 k213-0056 144 µM 1.41810666816177 0.088572978725312 no 426 0.0780798123769164 451 24048857 YMR208W ERG12 SGTC_1287 0971-0001 34.6 µM 1.41753325985091 0.0886596440914701 no 427 0.078163538648218 523 4665869 SGTC_1561 5-methoxyflavone 52.9 µM 1.41720231484083 0.0887096921077156 no 428 0.0782118926012857 381 94525 SGTC_1233 0325-0408 14.2 µM 1.41591623690653 0.0889043823351279 no 429 0.0784000152148779 471 12874 SGTC_1774 st048371 48.465 µM 1.41545064339353 0.088974943610279 no 430 0.0784682049906519 489 4242727 SGTC_2918 7977171 22.06 µM 1.41260574770581 0.0894069968942886 no 431 0.0788858390594879 443 2236483 SGTC_64 000l-0018 272.079 µM 1.41253312909446 0.089418045846649 no 432 0.0788965215553538 607 6811119 SGTC_1476 4112-3294 3.34 µM 1.4100666744917 0.0897939212719148 no 433 0.0792599981938802 457 704369 SGTC_1450 4112-4260 37.6 µM 1.40986229725904 0.0898251199604172 no 434 0.0792901736538041 481 1633175 SGTC_1635 st007035 42.4 µM 1.40799582208718 0.0901104148709501 no 435 0.0795661535597369 684 3716403 SGTC_372 0155-0182 15.9 µM 1.40630246720763 0.0903698298892066 no 436 0.0798171639169861 504 771486 SGTC_1773 st048542 73.5835 µM 1.39737426538653 0.0917467697355425 no 437 0.0811505268614792 501 3237138 SGTC_2475 5812728 15.03 µM 1.39445691194014 0.0922000467668261 no 438 0.0815898361822781 509 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2347 9049783 174.81 µM 1.39077094503823 0.0927751129700259 no 439 0.0821474481825154 529 6467988 YPL169C MEX67 SGTC_1801 st050089 28.441 µM 1.38951135692373 0.0929722344530534 no 440 0.0823386549456173 612 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_803 4488-1585 147 µM 1.38697573199471 0.0933699902609912 no 441 0.0827245814899856 455 747204 SGTC_2167 5876490 200 µM 1.38668398082144 0.0934158369045796 no 442 0.0827690737053127 499 686534 SGTC_2397 5161689 200 µM 1.38497232212719 0.0936851470208981 no 443 0.0830304653723426 516 2259942 SGTC_2020 4017018 200 µM 1.38246948837922 0.0940799708572287 no 444 0.0834137963555238 489 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_939 1165-0479 45.3 µM 1.37439336910114 0.0953623555170883 no 445 0.0846597968046157 512 1377347 SGTC_1935 st074532 41.6 µM 1.37280703758678 0.0956157496766046 no 446 0.0849061711740909 578 2829742 SGTC_2341 7987486 176.74 µM 1.37222779209134 0.0957083993810572 no 447 0.084996268081394 533 1258686 SGTC_1168 k815-0004 80.5 µM 1.36939540480033 0.0961623879716748 no 448 0.0854378549427726 506 642433 SGTC_3004 9076122 71.4286 µM 1.36542261108123 0.0968018310811864 no 449 0.0860601306010557 513 44782551 SGTC_1416 3966-0321 25.3 µM 1.36288759598783 0.0972114843589328 no 450 0.0864589692689794 518 582530 YLR208W SEC13 SGTC_543 3844-1095 191 µM 1.36213483798744 0.097333373130718 no 451 0.0865776677938698 541 4230703 SGTC_2807 7945238 51.95 µM 1.36072268053788 0.0975623361849136 no 452 0.0868006721542311 524 17148797 SGTC_3160 9100216 49.47 µM 1.35968633504513 0.0977306173198942 no 453 0.086964602105106 505 17191039 SGTC_2305 7443522 69.23 µM 1.35916967962939 0.0978145909498629 no 454 0.0870464134044356 520 5415886 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.35608537408509 0.0983169933644354 no 455 0.0875360029382523 560 4174840 SGTC_1456 k015-0012 13 µM 1.35289072827318 0.0988393589340546 no 456 0.088045270930317 592 2989616 SGTC_373 0844-0104 25.9 µM 1.34748599968657 0.0997277205711425 no 457 0.0889118797381798 550 5375804 SGTC_322 k048-0136 19.3 µM 1.34269901864312 0.100519403731872 no 458 0.0896847263060871 476 6823282 SGTC_1248 0469-0687 58.6 µM 1.34174867754924 0.100677117573335 no 459 0.0898387490122401 526 4017482 SGTC_3261 9137475 49.47 µM 1.33888293168877 0.101153794954949 no 460 0.090304393500289 304 17027690 SGTC_3068 9116768 49.47 µM 1.3377066230005 0.101349933108394 no 461 0.090496045579527 481 41904888 SGTC_232 clozapine 119 µM 1.33417456802088 0.101940533970848 no 462 0.0910733261265877 522 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2803 7707263 71.43 µM 1.33052862603966 0.102552801083622 no 463 0.091672080557637 500 2199229 SGTC_146 3448-8650 53.125 µM 1.32620365882406 0.103282558900286 no 464 0.0923861238525469 693 2891488 YIL048W NEO1 SGTC_3111 9122088 49.47 µM 1.32471217892003 0.10353509063357 no 465 0.0926333160891586 408 16876704 SGTC_1222 0366-0074 1.18 µM 1.32438938751767 0.10358980338723 no 466 0.0926868786527109 549 286520 SGTC_3283 9109332 35.8195 µM 1.31961329445155 0.104401798512705 no 467 0.0934820809511645 437 17027281 SGTC_2202 7226349 200 µM 1.31863415600879 0.104568832352397 no 468 0.0936457245426141 460 844334 SGTC_1235 benzylparaben 21.5 µM 1.31617728718137 0.104988808291669 no 469 0.0940572725665748 524 7180 SGTC_861 0443-0273 110 µM 1.31348775904925 0.105449953295599 no 470 0.0945093215056075 552 6149169 SGTC_1591 genipin 88.4 µM 1.31219948275701 0.105671358641157 no 471 0.0947264181730922 489 442424 A DNA cross-linking agent. SGTC_998 3996-0085 177 µM 1.31066391348149 0.105935703010826 no 472 0.0949856678090529 597 715391 SGTC_1026 k007-1105 30.6 µM 1.30476984923876 0.106954788405359 no 473 0.0959856143682179 632 7066794 SGTC_863 0466-0191 129 µM 1.30340190960217 0.107192313360727 no 474 0.0962187924597352 598 765160 YPR165W RHO1 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.29799835568095 0.108134288856369 no 475 0.0971439500034802 638 91467 include heat shock SGTC_2737 bleomycin 30.5 nM 1.29787638730385 0.108155619569411 no 476 0.0971649076289442 618 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1137 ixabepilone 100 µM 1.29692772861942 0.108321631274591 no 477 0.0973280273666364 613 154225 A novel microtubule stabilizer. SGTC_2070 5230947 200 µM 1.29379139168077 0.108871783572606 no 478 0.0978687434641126 567 2835538 SGTC_1931 st074438 57.1 µM 1.29368847598879 0.10888987023662 no 479 0.0978865237460592 511 2787313 SGTC_399 oxolinic acid 75 µM 1.29152609709865 0.109270391797462 no 480 0.0982606558789652 522 4628 A DNA gyrase inhibitor. SGTC_1433 4060-0023 7.6 µM 1.2854941194306 0.110336907531469 no 481 0.0993098351864852 573 3840627 SGTC_1414 3917-0015 5.4 µM 1.28542819183499 0.110348605302447 no 482 0.0993213474559805 507 6618702 SGTC_825 1988-2224 89.6 µM 1.28533806100368 0.110364598979701 no 483 0.0993370876705062 592 1180859 SGTC_2036 5160441 105 µM 1.28453356878438 0.110507429413496 no 484 0.0994776628955511 635 134534 YIL048W NEO1 SGTC_1980 st071811 45.7 µM 1.2818341069922 0.110987663018488 no 485 0.0999504234240718 543 4974850 SGTC_3277 9138724 49.47 µM 1.27702644716955 0.111846642726972 no 486 0.100796455170819 447 15943418 SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.27683215068545 0.111881457162236 no 487 0.10083075610233 587 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1282 0886-0010 32.4 µM 1.27440239976757 0.112317479361915 no 488 0.101260421144228 639 2836211 YNL267W PIK1 SGTC_2298 7976326 193.81 µM 1.27304239238182 0.112562063968208 no 489 0.101501499631318 482 2235818 SGTC_1390 3413-2614 145 µM 1.26940331057471 0.113218389002335 no 490 0.102148628022543 596 3421432 SGTC_320 4092-0846 5.34 µM 1.26619210242412 0.113799808754967 no 491 0.102722157154258 570 1359356 SGTC_1967 st070177 51.4 µM 1.26566392553818 0.113895643623658 no 492 0.102816714439546 529 5729214 SGTC_589 1227-0070 34.1 µM 1.26402196381297 0.114193936029934 no 493 0.103111071839961 575 2841384 SGTC_3303 9125618 40.5795 µM 1.26385401710789 0.114224477959771 no 494 0.103141214412516 663 22695467 SGTC_2394 5221648 200 µM 1.26373774348977 0.114245626293629 no 495 0.103162086602374 641 788586 SGTC_2641 levomentholum 100 µM 1.26236528735164 0.114495465103883 no 496 0.103408686990203 503 16666 SGTC_3056 9094900 49.47 µM 1.26127025713842 0.114695080676184 no 497 0.103605746681641 551 25236784 SGTC_2153 5569715 200 µM 1.25489017117906 0.115863046386744 no 498 0.104759316256465 554 2054701 SGTC_75 0159-0059 199.013 µM 1.25281799864157 0.116244197837921 no 499 0.10513597493182 566 5377270 SGTC_1309 pyrazolanthrone 13.4 µM 1.25277941856354 0.116251302610596 no 500 0.105142996911575 627 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1556 plumbagin 1.48 µM 1.2505503837062 0.116662317218748 no 501 0.105549281163741 505 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2866 9034245 58.44 µM 1.24513102018863 0.117665895693601 no 502 0.106541796629607 519 6462273 SGTC_2844 9010103 25.97 µM 1.24405309239392 0.117866236906361 no 503 0.106740011682801 589 2480525 SGTC_1446 4239-0190 62 µM 1.23826908875016 0.118945360751833 no 504 0.10780815071139 643 1340085 SGTC_2490 carminic acid 95.39 µM 1.23792223913072 0.119010293643392 no 505 0.107872447670993 505 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_604 1000-0114 314 µM 1.23507896051826 0.11954352070603 no 506 0.108400559408079 631 1572745 SGTC_1875 nocodazole 6 µM 1.23456122528233 0.119640797618311 no 507 0.108496923643006 591 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1343 1487-0095 224 µM 1.23171776509545 0.120176048692947 no 508 0.109027265652886 568 4560101 YGL055W OLE1 SGTC_2435 5706476 10.6 µM 1.23111214148829 0.120290268505666 no 509 0.109140462551036 639 5725375 SGTC_717 1532-0246 73.2 µM 1.23046050755585 0.120413251195063 no 510 0.109262353518831 612 9561992 SGTC_2710 st078562 53.7235 µM 1.22872349399335 0.120741509856835 no 511 0.109587747227735 582 17250908 SGTC_3126 9127922 49.47 µM 1.22848110415889 0.120787366421097 no 512 0.109633209235349 598 45595682 SGTC_2936 9038235 15.59 µM 1.2228641516933 0.121853445377867 no 513 0.110690505211077 585 4749415 SGTC_311 1315-0136 58 µM 1.22234696229312 0.121951937515372 no 514 0.110788223472066 611 6759207 SGTC_2848 9016370 25.97 µM 1.22089163976551 0.122229385165118 no 515 0.11106352514129 673 7894410 SGTC_1504 k297-0033 30 µM 1.21461368068973 0.12343131438957 no 516 0.112256734275472 490 4388117 SGTC_2115 tiliquinol 12.7705 µM 1.21209510863673 0.123915819969999 no 517 0.11273798795067 584 71208 A bioactive hydroxyquinoline. SGTC_2914 7968218 45.32 µM 1.21073601062616 0.124177826148361 no 518 0.112998298204842 573 2977111 SGTC_704 1310-0270 142 µM 1.21006953654119 0.12430645018235 no 519 0.113126105713684 635 5718033 SGTC_2508 celastrol 40.54 µM 1.20416888540311 0.125449292592514 no 520 0.11426215470149 553 122724 Celastrol is a natural product and antioxidant. SGTC_307 1501-1223 22.3 µM 1.20042149262652 0.126178886662772 no 521 0.114987842929288 618 2830329 SGTC_2616 abietic acid 100 µM 1.19611987303952 0.127020025150642 no 522 0.115824891724952 660 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_659 k018-0002 107 µM 1.19536233886078 0.127168556545236 no 523 0.115972746676731 642 6797879 YHR007C ERG11 SGTC_2995 9067767 71.4286 µM 1.19467362359064 0.127303699305144 no 524 0.116107285851958 558 11673567 SGTC_3279 9140807 49.47 µM 1.1941783795197 0.127400940016015 no 525 0.116204099255226 618 45595718 SGTC_2693 st077581 40.7 µM 1.18828932795635 0.128561210040219 no 526 0.11735972039754 726 25238761 SGTC_1212 0520-0165 585 µM 1.18809229106517 0.128600156932807 no 527 0.11739852557757 622 5403258 SGTC_2473 5854593 8.94 µM 1.18744826280151 0.128727514573678 no 528 0.117525426287781 607 2872951 SGTC_2583 asiatic acid 100 µM 1.18653576935176 0.128908111429124 no 529 0.117705392183541 598 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1182 1222-0449 220 µM 1.18557052721586 0.129099339261558 no 530 0.117895973590271 611 658318 SGTC_783 0848-0141 92.7 µM 1.1847532784415 0.129261401248911 no 531 0.11805750516876 607 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_306 1672-3436 11.6 µM 1.18379791167328 0.129451031002689 no 532 0.118246534549537 648 6797378 SGTC_1503 4585-0012 61.3 µM 1.18320495417788 0.129568823416261 no 533 0.118363965014515 607 2922052 SGTC_3309 9129340 25.759 µM 1.18090318238559 0.130026779288065 no 534 0.118820593489003 682 17158987 SGTC_2659 sanguinarine 24.21 µM 1.17944072372134 0.130318328494562 no 535 0.119111363582256 628 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2295 7971645 200 µM 1.17894796678723 0.13041666409005 no 536 0.119209447933655 637 2978226 YKL099C UTP11 SGTC_1526 st051518 75 µM 1.17710346349109 0.130785212554514 no 537 0.119577106439114 594 673993 SGTC_3233 9132340 49.47 µM 1.17576398724719 0.131053302839195 no 538 0.119844600481381 621 17682950 SGTC_1590 st077108 57.8 µM 1.17407341056167 0.13139220598175 no 539 0.120182811332655 621 5489485 SGTC_104 0074-0074 590.992 µM 1.17352323326812 0.131502628210663 no 540 0.120293022783336 498 3943124 SGTC_955 1216-0110 33 µM 1.17082082820208 0.132045938973557 no 541 0.120835401971764 681 3619719 SGTC_1148 3909-7663 27.7 µM 1.17073234523674 0.132063754352744 no 542 0.120853189767874 661 4084526 SGTC_3336 9143619 71.43 µM 1.16797569908887 0.132619614632924 no 543 0.121408283632298 700 45595730 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.1677617958861 0.132662814146067 no 544 0.121451431213095 662 94937 An inhibitor of serotonin biosynthesis. SGTC_755 1995-0008 37.3 µM 1.16569170606039 0.133081386659877 no 545 0.1218695573521 677 689533 SGTC_643 k048-0106 28.4 µM 1.16426991096095 0.13336939989874 no 546 0.122157323125244 656 6763920 SGTC_623 k072-0108 16.9 µM 1.15917911641763 0.134404157660581 no 547 0.123191591030709 655 5382803 SGTC_1866 st057638 64 µM 1.15792793130461 0.134659315882954 no 548 0.123446723992194 651 688802 SGTC_1936 st074407 74.3 µM 1.1577456437108 0.134696518107881 no 549 0.123483925678077 686 809813 SGTC_2140 5586273 200 µM 1.15697922028948 0.134853011054452 no 550 0.123640425107165 610 854421 SGTC_1784 st039334 36.3 µM 1.1515502432739 0.135965103122657 no 551 0.124752968857773 657 3496984 SGTC_2925 9010536 32.5 µM 1.15053367418737 0.136174036898943 no 552 0.124962066489694 725 2994177 SGTC_3190 9110366 49.47 µM 1.14957190139648 0.13637191066395 no 553 0.1251601183685 557 17123768 SGTC_3168 9103419 49.47 µM 1.14918260354497 0.136452060146674 no 554 0.125240346335541 558 16649256 SGTC_3287 9117173 37.0625 µM 1.14773895970309 0.136749561918799 no 555 0.125538171331811 606 2789709 SGTC_2566 crystal violet carbinol 226 nM 1.14675449080885 0.136952692421558 no 556 0.12574155135357 574 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2187 6125751 200 µM 1.14202632435876 0.137931151772781 no 557 0.126721538853461 681 874498 SGTC_2218 6965428 192.983 µM 1.14099258182671 0.138145710904212 no 558 0.126936505006222 670 675684 SGTC_2671 danthron 100 µM 1.13957006056471 0.138441335152413 no 559 0.127232732245243 664 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1284 0929-0043 16 µM 1.13913056700524 0.13853275654257 no 560 0.127324349989106 687 1239883 SGTC_2602 kawain 100 µM 1.13909682087355 0.138539777954861 no 561 0.12733138667466 735 5369129 SGTC_1974 st069448 26.9 µM 1.13614850676308 0.139154157137773 no 562 0.127947208519465 650 6323587 YNR016C ACC1 SGTC_1615 st002656 86.5 µM 1.13213632974562 0.139993202150062 no 563 0.128788561608786 685 1584458 SGTC_3265 9137266 49.47 µM 1.12822445247618 0.140814575580179 no 564 0.129612569777381 627 17224265 SGTC_1797 st048695 56.8 µM 1.12654355952871 0.141168513537767 no 565 0.129967756843587 699 592262 YIL048W NEO1 SGTC_2388 9080168 200 µM 1.12498241569825 0.141497776296728 no 566 0.130298242876533 629 15943073 SGTC_2237 6667747 47.222 µM 1.12478056998962 0.141540385782918 no 567 0.130341014969981 650 729940 YDL015C TSC13 SGTC_396 dithiazanine 1.25 µM 1.12467069524412 0.141563583917839 no 568 0.130364302048397 642 10578 An antihelmenthic. SGTC_1568 digitonin 820 nM 1.12445693705444 0.14160872260942 no 569 0.130409614642091 724 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_3081 9117243 49.47 µM 1.12296613310026 0.141923802448091 no 570 0.130725939116363 660 45595589 SGTC_324 1315-0088 19.6 µM 1.12205884589939 0.142115788806351 no 571 0.130918710198192 593 6787421 SGTC_1762 st045503 25.4615 µM 1.12180169450317 0.14217023524072 no 572 0.130973382800043 687 4645554 SGTC_1961 st076550 68.7 µM 1.12128316128626 0.142280066740915 no 573 0.131083675401778 622 1579337 SGTC_1872 amphotericin b 148 nM 1.11920008703958 0.142721865091472 no 574 0.131527394166686 702 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_787 4152-0075 138 µM 1.1187694717406 0.142813309664538 no 575 0.131619249338223 667 9566539 SGTC_212 3807-4682 38.772 µM 1.11633160344089 0.143331757005124 no 576 0.132140109298399 845 3125501 YBL034C STU1 SGTC_1841 st054148 70 µM 1.11618995090701 0.14336192044956 no 577 0.13217041753529 637 675442 SGTC_3048 9093155 49.47 µM 1.11469771401061 0.143679937296389 no 578 0.132489990482226 612 25236002 SGTC_1596 piperlongumine 63 µM 1.11227278576295 0.144197738588836 no 579 0.133010440595207 761 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_96 0929-0093 37.281 µM 1.10838750904298 0.14502999165386 no 580 0.133847248536367 665 6991579 SGTC_758 0868-0029 16 µM 1.10751903744974 0.145216465520809 no 581 0.13403479303127 701 762687 SGTC_53 0973-0023 39.979 µM 1.10599263818646 0.145544597117308 no 582 0.134364852901981 681 674768 SGTC_2147 5545932 89.7195 µM 1.10522470565532 0.145709868729314 no 583 0.134531117101038 674 797404 SGTC_2210 7115885 190.385 µM 1.10098775825639 0.146623996680051 no 584 0.135450992555554 726 2927039 SGTC_538 2922-0838 53.3 µM 1.09856481844209 0.147148475759497 no 585 0.135978965191769 776 777039 SGTC_1792 st045773 43.6 µM 1.09714059622322 0.147457354741425 no 586 0.136289968121666 686 2919270 SGTC_1690 st023502 41.2 µM 1.09440796730757 0.148051210738499 no 587 0.136888045588368 690 24207482 SGTC_305 1682-2595 20.8 µM 1.0940845404749 0.148121603773199 no 588 0.136958951013579 734 226033 SGTC_3076 9116187 49.47 µM 1.09208727686406 0.14855679930908 no 589 0.137397370606029 652 27241210 SGTC_445 e6 berbamine 66 µM 1.09190535544728 0.148596481677378 no 590 0.137437351764612 823 6610268 A calcium/calmodulin antagonist. SGTC_1811 st050069 61.5 µM 1.08921039104754 0.149185162109675 no 591 0.138030558853324 695 3877702 SGTC_888 0916-0002 6.97 µM 1.08895582039096 0.149240850203488 no 592 0.138086684276628 750 2802138 YIL048W NEO1 SGTC_1050 3232-1156 69.3 µM 1.08598044730626 0.149892751122313 no 593 0.13874382144714 700 700529 SGTC_1888 azatryptophan 97.5 µM 1.08520986128469 0.150061894805099 no 594 0.138914358798801 652 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1719 st032227 49.2 µM 1.08158947081055 0.150858273572096 no 595 0.139717492585194 699 3125804 SGTC_532 1548-0774 215 µM 1.07867541092651 0.15150132049089 no 596 0.140366225447643 747 5932993 SGTC_1735 st034310 56.75 µM 1.07856578893427 0.151525546340537 no 597 0.14039066953305 713 871153 SGTC_430 0958-0115 16.4 µM 1.07521044795876 0.152268303845071 no 598 0.141140259396458 700 6833180 SGTC_2533 agelasine 13.65 µM 1.07325480854982 0.152702328482294 no 599 0.141578402730658 756 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_999 SEC7.066 22.7 µM 1.07273173174862 0.152818556443711 no 600 0.141695749394213 780 740511 YDR170C SEC7 SGTC_3322 9139058 2.11 µM 1.06957516411601 0.153521192552515 no 601 0.142405289624645 754 4908926 YPR165W RHO1 SGTC_1049 3226-0134 66 µM 1.06808040190169 0.153854664410578 no 602 0.142742122700711 781 5702385 SGTC_2912 7964298 10.93 µM 1.06743201087662 0.153999465257412 no 603 0.142888399945692 782 2975850 SGTC_443 clozapine 122 µM 1.06695249490168 0.154106610347407 no 604 0.142996644063386 651 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_377 3970-0964 33.1 µM 1.06338893023952 0.154904413095773 no 605 0.143802805363759 829 16481235 SGTC_1885 st057546 99.9 µM 1.06333655058977 0.154916160039752 no 606 0.143814677681622 764 702008 SGTC_2893 9048488 25.97 µM 1.06307214974437 0.154975464986094 no 607 0.143874616600649 708 6467338 SGTC_706 4262-0057 46.9 µM 1.0626289101244 0.155074916989892 no 608 0.143975135561014 705 883298 SGTC_1081 sertraline 6 µM 1.05895671619001 0.155900486928888 no 609 0.144809746275283 766 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_351 caspofungin 25 nM 1.05598983786927 0.156569602444799 no 610 0.145486428823206 872 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_3304 9125678 46.087 µM 1.05558267354277 0.156661576912669 no 611 0.145579460124845 740 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_3252 9135871 49.47 µM 1.05493047151895 0.156808977111506 no 612 0.145728562420483 741 17682838 SGTC_1057 3448-5381 134 µM 1.05380710448206 0.157063076344322 no 613 0.145985620086087 761 5497911 SGTC_2617 dihydrotanshinone i 20.83 µM 1.05172404303204 0.157534969289566 no 614 0.146463088377018 770 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_975 1335-0046 28.5 µM 1.04899764090023 0.158154009714932 no 615 0.147089602093646 743 16486740 SGTC_835 0312-0010 67.2 µM 1.04897531472398 0.158159085543421 no 616 0.147094739944985 713 1626196 SGTC_2730 imipramine 71.33 µM 1.04896634720041 0.158161124328883 no 617 0.147096803646297 876 3696 A tricyclic antidepressant. SGTC_3207 9114163 49.47 µM 1.04863305582241 0.158236911062844 no 618 0.14717351794975 807 849233 SGTC_1794 st048918 76.9 µM 1.04753869374037 0.158485924327478 no 619 0.14742559791769 679 672303 SGTC_1108 betulinic acid 729.144 nM 1.04455638952704 0.159165827492214 no 620 0.148114022159681 762 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1070 indatraline 8.81 µM 1.04087225909773 0.160008366373448 no 621 0.148967419057863 752 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_910 3454-3003 490 µM 1.04070777151224 0.160046051604719 no 622 0.149005597638351 771 820824 SGTC_1321 1326-2144 215 µM 1.03812116412563 0.160639424194059 no 623 0.149606824705025 754 3513030 SGTC_1002 4049-0206 172 µM 1.03731682502213 0.16082423359077 no 624 0.149794113552457 797 4662749 SGTC_1000 4048-0884 8.67 µM 1.03592960052087 0.161143295982105 no 625 0.150117493486515 740 13040088 SGTC_2894 9048625 32.47 µM 1.03426628623456 0.161526403289313 no 626 0.15050584661386 759 4092861 SGTC_2471 5466956 24.79 µM 1.03114612016411 0.162246664326157 no 627 0.15123615139089 750 724419 SGTC_1559 coumarin 343 70.1 µM 1.02950297047262 0.162626809236938 no 628 0.151621692321173 731 108770 A hepatotoxic, DNA x-linker. SGTC_734 2023-0417 80 µM 1.02932212566951 0.162668683295203 no 629 0.151664164769538 762 3935732 SGTC_2421 5690543 90.72 µM 1.02878154627783 0.162793894605172 no 630 0.151791170110307 775 3397993 SGTC_1982 st072467 71.9 µM 1.02839470648011 0.162883534558315 no 631 0.151882098779873 812 3163533 SGTC_1754 st042065 16.137 µM 1.02747882971817 0.163095892839909 no 632 0.152097524526171 870 1126236 YIL048W NEO1 SGTC_1525 8-methoxypsoralen 92.5 µM 1.0274217731795 0.163109128113419 no 633 0.152110951653505 849 4114 Related to psoralen; DNA damaging agent. SGTC_2409 alverine citrate 63.97 µM 1.0267241608929 0.16327100806725 no 634 0.15227518454872 752 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_70 0141-0289 43.283 µM 1.02505488064846 0.163658785786879 no 635 0.15266864660604 945 352408 SGTC_813 k007-0158 173 µM 1.02408239617315 0.163884971626005 no 636 0.152898179221115 849 6523916 SGTC_2472 5377652 49.4 µM 1.02394136839273 0.163917789484384 no 637 0.152931484576104 795 1610903 SGTC_2094 5332512 191.667 µM 1.01993251655712 0.164852452292963 no 638 0.153880233404024 816 755774 SGTC_1523 st012844 44.7 µM 1.01988744195149 0.164862981011821 no 639 0.153890923014689 781 4274103 SGTC_3027 9089541 49.47 µM 1.01934461948699 0.164989810003711 no 640 0.15401969397897 763 9943819 SGTC_1562 morin hydrate 59.1 µM 1.01835797847813 0.165220497720205 no 641 0.15425393222373 766 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_893 0958-0369 48.9 µM 1.0172198327605 0.165486868103813 no 642 0.154524431654561 806 6819948 SGTC_1702 st027038 51 µM 1.01606562743913 0.165757280596938 no 643 0.154799067933731 785 5521182 SGTC_3266 9136860 49.47 µM 1.0144211970654 0.16614303840142 no 644 0.155190906997177 780 4871271 YPR165W RHO1 SGTC_35 0133-0054 64.071 µM 1.0136188218437 0.166331473515906 no 645 0.155382336485515 720 99677 SGTC_664 1222-0054 14.9 µM 1.00480362641079 0.168410774425551 no 646 0.157495708674061 795 6813991 SGTC_3170 9103054 49.47 µM 1.00444363931464 0.168496040806298 no 647 0.157582412267675 743 16432970 SGTC_3332 9141069 11.198 µM 1.00192671903608 0.169092972682598 no 648 0.15818949345753 735 17332883 SGTC_3139 9095020 49.47 µM 1.00164875143555 0.169158980757458 no 649 0.158256633236243 636 25236292 SGTC_2917 7979103 53.79 µM 0.998139077537482 0.169993834705349 no 650 0.159105961663975 853 2980565 SGTC_1915 st067105 30.6 µM 0.997339180595411 0.170184476918414 no 651 0.159299950901103 785 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.995343558441927 0.170660697441852 no 652 0.15978459971828 758 15053 SGTC_386 1509-0011 3.07 µM 0.995130101733858 0.170711685627183 no 653 0.159836496009754 880 3107280 SGTC_2785 7756463 72.73 µM 0.995001149905163 0.17074249294254 no 654 0.159867852541063 798 2201551 SGTC_1760 st045453 10.4495 µM 0.99479242359036 0.170792366370962 no 655 0.159918615937582 848 3323419 YIL048W NEO1 SGTC_2989 9073649 71.4286 µM 0.992603760884479 0.171315890570722 no 656 0.160451545634496 879 21367202 SGTC_3150 9097574 49.47 µM 0.990876647553013 0.171729736390279 no 657 0.160872908277507 801 17217476 SGTC_3007 9078383 71.4286 µM 0.990016073923731 0.171936182675845 no 658 0.161083131230226 813 6496995 SGTC_2262 9014885 67.46 µM 0.989057702994495 0.172166276340077 no 659 0.161317455220957 746 6457424 SGTC_196 k015-0023 18.111 µM 0.98899659809029 0.172180953574826 no 660 0.16133240305251 831 5211998 SGTC_2837 9008476 45.46 µM 0.988990869976292 0.172182329493439 no 661 0.161333804342866 814 2992805 SGTC_2335 9018011 154.17 µM 0.988751759952299 0.172239771050755 no 662 0.161392305821248 850 6458208 SGTC_1138 3761-0006 1.03 µM 0.987232391996197 0.172605055464616 no 663 0.161764362796719 821 12061087 SGTC_1440 4100-1550 40 µM 0.980550986500639 0.174217246472403 no 664 0.16340710734512 827 742806 SGTC_2006 4011487 200 µM 0.97804172187315 0.174825183865745 no 665 0.164026844716337 863 45595294 SGTC_2041 5107442 45.335 µM 0.977682364272012 0.174912358082547 no 666 0.164115723403566 832 793005 SGTC_925 2064-1272 59.6 µM 0.976700474213219 0.175150689014267 no 667 0.16435873016693 773 6815817 SGTC_7 0192-1582 4.227 µM 0.975902904180811 0.175344432089075 no 668 0.164556291407898 927 252616 SGTC_3177 9107506 49.47 µM 0.975773377615109 0.175375909074515 no 669 0.164588390168819 799 8897194 SGTC_1358 1509-0022 2.48 µM 0.973563461685841 0.175913505163083 no 670 0.165136667887899 849 3258434 SGTC_3238 9133470 49.47 µM 0.971965485536191 0.176302886913416 no 671 0.165533859693524 829 3534688 SGTC_817 1391-0715 46 µM 0.970295430427606 0.176710414635823 no 672 0.16594962718155 793 1353946 SGTC_3119 9125183 49.47 µM 0.96960930883846 0.176878014851982 no 673 0.166120635554792 681 22695334 SGTC_1851 st056236 18.9 µM 0.965596021013204 0.177860359691564 no 674 0.167123183572842 879 5393171 SGTC_2898 9056270 58.44 µM 0.964055279523811 0.178238404106242 no 675 0.167509105951777 786 19154699 SGTC_442 cape 100 µM 0.959810551004623 0.179282529976171 no 676 0.168575285569667 821 5281787 SGTC_3327 9140648 26.9345 µM 0.959777323708866 0.179290718428644 no 677 0.168583648684666 839 8029710 SGTC_426 0988-0037 14.6 µM 0.957505059838638 0.179851247408637 no 678 0.16915619686819 895 5383008 SGTC_2150 5556613 200 µM 0.956307574577676 0.180147089127896 no 679 0.169458432101626 878 743190 SGTC_2017 5132927 60.65 µM 0.955476051516495 0.180352698572868 no 680 0.169668505275673 838 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2854 9024559 71.43 µM 0.955334032513398 0.180387830112354 no 681 0.169704401170647 815 3163529 SGTC_793 0488-0545 106 µM 0.953832953097058 0.180759417767281 no 682 0.170084103034236 845 292548 SGTC_1378 2093-0007 380 nM 0.952870033854339 0.180998037967853 no 683 0.170327962348079 823 3618014 SGTC_106 0092-0003 11.579 µM 0.950542516737244 0.181575632703529 no 684 0.170918330537253 796 1072148 SGTC_2930 9013230 14.89 µM 0.948828776016305 0.182001649707318 no 685 0.171353851904023 889 2995857 SGTC_2959 9079155 11 µM 0.94805894279825 0.182193225004963 no 686 0.171549724118284 794 16189457 SGTC_3263 9137018 49.47 µM 0.947853692793131 0.182244323356249 no 687 0.171601970970777 800 43844957 SGTC_2012 4023501 200 µM 0.946910065260863 0.182479360919365 no 688 0.171842304286574 783 3477460 SGTC_2199 6590217 200 µM 0.946828794755086 0.182499612527316 no 689 0.17186301319106 794 703109 SGTC_1824 st053723 68.6 µM 0.944428877755424 0.183098274957965 no 690 0.172475265168546 878 675225 SGTC_2400 5203494 178.7 µM 0.941593309354004 0.183807188073431 no 691 0.173200448257027 795 6777674 SGTC_2212 7123476 200 µM 0.94126709816544 0.183888852803527 no 692 0.173283999575981 800 1085715 SGTC_222 nsc-310342 10.666 µM 0.940838437571447 0.183996199388686 no 693 0.173393829910278 787 432556 SGTC_1316 1272-0050 65.9 µM 0.939559914381974 0.184316603010858 no 694 0.173721673012232 847 7340392 SGTC_710 3448-4187 58 µM 0.939338746340824 0.184372063910702 no 695 0.173778425626641 929 3946412 SGTC_2207 7258803 200 µM 0.937579882771262 0.184813492436135 no 696 0.17423017687337 824 3666799 SGTC_867 0518-0118 155 µM 0.935659491761302 0.185296209597291 no 697 0.174724266694078 874 6848158 SGTC_2385 9074692 200 µM 0.935519509996954 0.185331426559117 no 698 0.174760316798816 872 17046906 SGTC_3127 9126946 49.47 µM 0.935224277123401 0.185405715606596 no 699 0.174836364867536 767 27243249 SGTC_608 k048-0125 159 µM 0.935107298601475 0.185435155866001 no 700 0.174866502790744 886 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1932 st074806 40.9 µM 0.934680894780565 0.18554249448235 no 701 0.174976387840096 916 17251235 SGTC_1207 2099-0101 141 µM 0.932476099953322 0.186098122329241 no 702 0.175545266278247 937 5837381 SGTC_887 0885-0007 9.62 µM 0.928216531476022 0.187174488682382 no 703 0.176647630416689 895 5719458 SGTC_847 0342-0274 5.54 µM 0.92714310667894 0.187446342599691 no 704 0.176926118730597 915 18097 SGTC_2233 sulbentine 40.3845 µM 0.926771934534169 0.187540401841234 no 705 0.177022479802396 919 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_3262 9137218 49.47 µM 0.926471086077887 0.187616661657162 no 706 0.177100608264738 735 17650664 SGTC_491 tetrandrine 80.3 µM 0.925943264689493 0.18775050142251 no 707 0.177237732802299 856 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1610 st001799 48.1 µM 0.925498991294515 0.187863201605433 no 708 0.17735320407636 810 621897 SGTC_1021 4476-0760 85.3 µM 0.924254863206744 0.188179025589076 no 709 0.177676818586731 838 746768 SGTC_1838 st055369 84.5 µM 0.923655923836283 0.188331184107689 no 710 0.17783274357623 876 676036 SGTC_385 1494-0393 12.4 µM 0.923559196582653 0.188355764455415 no 711 0.17785793317605 899 3090647 SGTC_742 0kpi-0133 140 µM 0.922069402021572 0.188734601256234 no 712 0.178246187985141 912 2728852 SGTC_2312 7706453 155.7 µM 0.920938422027595 0.189022509192431 no 713 0.178541288644406 849 976098 SGTC_381 3461-2219 42.7 µM 0.919480140537924 0.189394135689976 no 714 0.178922244251716 907 2883159 SGTC_2172 5754775 163.918 µM 0.918172510920648 0.189727752386771 no 715 0.179264278841603 811 2263357 SGTC_2654 protoveratrine a 100 µM 0.911761942249346 0.191368509953148 no 716 0.180947024295608 907 5702278 A heart drug and vasodilator. SGTC_2820 7989630 71.43 µM 0.910673105471016 0.191648054492903 no 717 0.181233819388885 787 2984098 SGTC_1204 4049-0315 18.3 µM 0.909168444044877 0.192034767910959 no 718 0.181630609212222 869 588402 SGTC_3024 9090631 49.47 µM 0.90889586648684 0.192104874192639 no 719 0.181702547952463 870 25236383 SGTC_2976 9009005 19.48 µM 0.907362243901696 0.192499610016711 no 720 0.182107634271441 913 2993148 SGTC_2192 5915882 198.485 µM 0.907034151458606 0.192584121368012 no 721 0.182194368846025 880 2876149 SGTC_34 0469-0683 81.75 µM 0.906673259269152 0.192677107594933 no 722 0.182289804182572 912 3690923 SGTC_248 streptozotocin 5.23457 mM 0.90662084556363 0.192690614609408 no 723 0.18230366720642 944 5300 DNA alkylating agent. SGTC_1648 st011736 69.8 µM 0.903669127240655 0.193452206106258 no 724 0.183085437097341 890 2855514 SGTC_1210 3013-0140 750 nM 0.903555836984757 0.193481473387221 no 725 0.183115483918473 968 905973 SGTC_2135 5326629 150.42 µM 0.902436161107109 0.193770874473558 no 726 0.183412609563763 855 5020077 SGTC_3029 9088683 49.47 µM 0.899673535226175 0.194486054576678 no 727 0.184147005569017 914 25236615 SGTC_697 0508-1955 564 µM 0.895432217901696 0.195587155584076 no 728 0.185278042272332 950 6243113 SGTC_3012 9080433 71.4286 µM 0.894195506252896 0.195908933375389 no 729 0.185608648085914 974 17688859 SGTC_2628 lathosterol 100 µM 0.893260961043977 0.196152303964597 no 730 0.185858719462896 929 6710616 SGTC_2142 5622915 118.518 µM 0.892945655870114 0.196234455844596 no 731 0.185943137887766 876 5322196 SGTC_669 0108-0021 26.2 µM 0.891377240223588 0.196643412035994 no 732 0.186363411798729 1015 17201 SGTC_2367 9070478 135.38 µM 0.891270170505356 0.196671348718577 no 733 0.186392123727911 897 572802 SGTC_2176 5809774 33.9695 µM 0.890968244235372 0.1967501404139 no 734 0.186473103354026 956 2870539 SGTC_108 0509-0257 621.132 µM 0.890169147442414 0.196958767637261 no 735 0.186687534189567 934 536624 SGTC_2884 9058502 51.95 µM 0.889613367295507 0.197103948973565 no 736 0.186836763039907 901 6471554 SGTC_1637 st007924 17.4 µM 0.887373987894231 0.197689577312487 no 737 0.187438791649663 880 683336 SGTC_3208 9114115 49.47 µM 0.885695191536464 0.198129294419284 no 738 0.187890900067793 826 650895 SGTC_1667 st014849 34.6 µM 0.884258772495603 0.19850599546882 no 739 0.188278269110369 940 5348460 SGTC_486 niguldipine 82 µM 0.882843329779676 0.198877617803652 no 740 0.188660462926914 901 1236 A calcium channel blocker. SGTC_2138 5575593 77.673 µM 0.88055149371049 0.19948022433268 no 741 0.189280311249656 935 762213 SGTC_1769 st044406 64.4 µM 0.880174000009566 0.199579586390866 no 742 0.18938252805138 924 670903 SGTC_1699 st031318 29.054 µM 0.878450483699098 0.200033620288759 no 743 0.189849649029949 975 5340658 SGTC_187 1488-2104 32.728 µM 0.87724336846709 0.200351985704289 no 744 0.190177232379899 980 2852859 SGTC_2048 5246248 200 µM 0.87599723959751 0.200680959721548 no 745 0.190515767213805 949 677046 SGTC_2469 5655019 90.81 µM 0.874232876054271 0.201147300232796 no 746 0.190995722794695 1005 2788239 SGTC_2361 9034121 116 µM 0.872146507743838 0.201699587898547 no 747 0.191564228578919 920 6496917 SGTC_573 3702-0553 84.7 µM 0.872124463703373 0.201705428075076 no 748 0.19157024079616 907 1222756 SGTC_2358 9037157 4 µM 0.868017655835941 0.202795219977328 no 749 0.192692333607989 947 2388925 SGTC_2928 9011484 9.79 µM 0.867209481888251 0.203010092366365 no 750 0.192913620967189 884 2994751 SGTC_598 3937-0236 20.2 µM 0.866841067633977 0.203108089211841 no 751 0.193014548528813 1006 1379313 SGTC_973 1325-0077 65.9 µM 0.866512177904779 0.203195596533429 no 752 0.193104675530584 1020 2835149 SGTC_2708 st078559 56 µM 0.863547558826504 0.203985404614057 no 753 0.193918241379397 868 17250902 SGTC_1162 k048-0130 20.1 µM 0.862505256235716 0.204263519840452 no 754 0.194204770948706 929 6797406 SGTC_1417 3966-0327 90.4 µM 0.86056531580888 0.204781750519332 no 755 0.194738747777162 995 651118 SGTC_1125 tnp00248 1.32998 µM 0.860229494915694 0.204871540178992 no 756 0.194831274507541 1092 24207736 SGTC_2123 5259487 200 µM 0.858365889774589 0.20537024436592 no 757 0.195345228270224 983 2173474 SGTC_27 0485-0001 32.618 µM 0.857429843648316 0.205621003833196 no 758 0.195603685916872 913 2054479 SGTC_1494 4358-1428 177 µM 0.857226227911566 0.205675574961299 no 759 0.195659935034821 1003 1564571 SGTC_257 daunorubicin 18.5 µM 0.854954781149026 0.206284928847292 no 760 0.196288090807379 978 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1717 st033143 58.0435 µM 0.853762626530861 0.206605172130375 no 761 0.19661826309629 978 674616 SGTC_3178 9107506 49.47 µM 0.851422438287258 0.20723466229249 no 762 0.197267365857815 949 8897194 SGTC_2415 st077333 57.7 µM 0.851384058480781 0.207244995569386 no 763 0.197278022135467 1043 2766255 SGTC_1611 st001856 99.4 µM 0.851138103533017 0.207311223057472 no 764 0.197346320589547 926 647478 SGTC_833 3852-0053 558 µM 0.850658338279971 0.207440443891866 no 765 0.197479586239087 1015 3123681 SGTC_1578 josamycin 24.2 µM 0.849553126323859 0.207738304776927 no 766 0.197786790842331 894 5282165 A P450 substrate. SGTC_143 4032-1194 15.74 µM 0.847417154460302 0.208314676733798 no 767 0.198381323069974 1029 1806963 SGTC_2829 7992743 58.44 µM 0.843026010629611 0.20950254461137 no 768 0.199606948443061 1004 16462845 SGTC_756 0508-1999 28.3 µM 0.842713972989205 0.209587106673788 no 769 0.199694215267866 932 6753853 SGTC_493 zm226600 134 µM 0.840220021631774 0.210263687488032 no 770 0.200392517257827 983 5240098 A potassium channel opener. YCR052W RSC6 SGTC_927 2425-1185 123 µM 0.837808922340109 0.210919009261168 no 771 0.201069013446083 975 730375 SGTC_3042 9091578 49.47 µM 0.837605465131696 0.210974362400268 no 772 0.201126161223536 968 25236497 SGTC_1249 0481-0015 10.2 µM 0.837530397552857 0.210994787647052 no 773 0.20114724892931 969 4227577 SGTC_3240 9133527 49.47 µM 0.83637943227058 0.211308100585128 no 774 0.20147073981214 954 17617455 SGTC_1945 st075991 56.6 µM 0.836220117420998 0.211351490344946 no 775 0.20151554147428 902 1084980 SGTC_197 4544-0043 41.561 µM 0.833430718337109 0.212112034719796 no 776 0.202300928088608 1046 896523 SGTC_1237 0330-0133 46.1 µM 0.83249583089992 0.212367294306704 no 777 0.202564565226821 954 X1237 YHR072W ERG7 SGTC_192 3455-0609 60.9 µM 0.830837000411067 0.212820659246871 no 778 0.203032858628548 989 3769639 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.830802180238649 0.212830181787759 no 779 0.203042695402009 1020 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_3214 9129694 49.47 µM 0.830664493498244 0.212867838477729 no 780 0.203081594989094 962 17158655 SGTC_1164 k060-0068 93.7 µM 0.830443761938809 0.212928215657122 no 781 0.20314396588075 1058 5963676 SGTC_246 cycloheximide 667 µM 0.830114224264703 0.213018373402507 no 782 0.203237102789414 901 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1441 4106-0040 13 µM 0.829430622417498 0.213205470071376 no 783 0.203430389759627 1018 2904180 SGTC_175 3793-3120 23.7 µM 0.829003998140913 0.213322282469002 no 784 0.20355107242522 972 5322297 SGTC_1362 1611-0397 101 µM 0.828769704634443 0.213386449367411 no 785 0.203617367087835 1012 27816 SGTC_1252 0493-0875 34.8 µM 0.827095147176468 0.213845394586099 no 786 0.20409156728256 955 3960963 SGTC_31 0508-1974 57.237 µM 0.826485392514525 0.214012652422394 no 787 0.204264400500175 983 6810525 SGTC_1025 k007-0731 70 µM 0.82557756043931 0.214261814964279 no 788 0.204521884318875 996 6256118 SGTC_2859 9028643 45.46 µM 0.825462245182991 0.214293476330707 no 789 0.204554604421515 971 17151580 SGTC_2971 9092186 9.93 µM 0.822919318651538 0.214992362693501 no 790 0.205276937985648 921 25236400 SGTC_829 1635-0120 117 µM 0.822600225371525 0.215080154210284 no 791 0.205367685230968 1056 285054 SGTC_1903 st060211 78.3 µM 0.822570429245553 0.215088353023158 no 792 0.205376160196112 1050 688960 SGTC_1318 1280-3875 124 µM 0.819628613529045 0.215898726927191 no 793 0.206213928351221 1002 373245 SGTC_19 0279-0214 38.434 µM 0.819346025594931 0.215976663676655 no 794 0.2062945100455 1116 3566274 YBR002C RER2 SGTC_313 3474-0040 5.03 µM 0.818659509667541 0.21616607021718 no 795 0.206490352027433 999 1043375 YIL048W NEO1 SGTC_1176 0848-0131 83.3 µM 0.818178019087221 0.216298968590913 no 796 0.206627772242482 1081 6769040 SGTC_2580 diallyl disulphide 81.36 µM 0.81800355127846 0.216347135905161 no 797 0.206677579736131 949 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_675 1309-0189 238 µM 0.812001159424176 0.218008062059445 no 798 0.208395483104325 1001 4246530 SGTC_1911 st060208 74.3 µM 0.80889663552729 0.218869993479072 no 799 0.209287302168852 1040 688783 SGTC_2185 6113692 200 µM 0.807815163076793 0.219170710321316 no 800 0.209598497438425 972 874150 SGTC_2259 7964009 200 µM 0.807181114617905 0.219347125765315 no 801 0.209781072288063 964 313134 SGTC_1366 1683-0113 21.9 µM 0.805820087652343 0.219726088642921 no 802 0.210173296892224 1051 708623 SGTC_3075 9116269 49.47 µM 0.805166506644056 0.21990820454701 no 803 0.210361800702567 1023 17015205 YNL244C SUI1 SGTC_644 1498-1197 63.3 µM 0.804197928058108 0.220178251625294 no 804 0.210641337611982 1056 6741615 SGTC_1246 0422-0085 105 µM 0.803525485267611 0.220365845588464 no 805 0.210835536275992 1050 264295 SGTC_1082 camptothecin 424.86 nM 0.803410306279447 0.220397986703921 no 806 0.210868810015218 1032 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2 0422-0095 29 µM 0.803371888930651 0.220408707802361 no 807 0.210879908981631 956 6790840 SGTC_1763 st044482 94.5 µM 0.801257070243032 0.220999349519309 no 808 0.211491419098436 1033 88505 SGTC_2840 9008771 71.43 µM 0.800586974932986 0.221186687363998 no 809 0.211685396831222 1011 2992978 SGTC_2412 st077135 33.4 µM 0.800209992161371 0.221292119962255 no 810 0.21179457073804 1016 13258915 SGTC_1130 3454-2858 15.9 µM 0.800097079542102 0.221323704374538 no 811 0.211827276552192 963 715628 YIL048W NEO1 SGTC_1383 3049-0032 20.7 µM 0.799409287121642 0.221516152354685 no 812 0.212026563544964 1067 712864 SGTC_1728 st035614 33.7865 µM 0.79900939432786 0.2216280884482 no 813 0.212142482371497 1041 15945546 SGTC_2679 rapamycin 1 nM 0.796352721186316 0.22237255199155 no 814 0.212913525064224 1087 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_435 c-PAF 6.7 µM 0.796131401421025 0.222434635399823 no 815 0.212977832117178 1028 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2915 7971052 15.16 µM 0.795282006519557 0.222672994756829 no 816 0.213224738955266 922 5741558 SGTC_1112 tnp00069 1.16933 µM 0.794425644677632 0.222913456514565 no 817 0.213473839884559 1080 145826 SGTC_3052 9092717 49.47 µM 0.789034200180352 0.224430737898957 no 818 0.215046008931745 1031 25237534 SGTC_1934 st074720 32.6 µM 0.786228337863676 0.225222687793782 no 819 0.21586686355933 1122 17250992 SGTC_2491 paeonol 100 µM 0.786203847362257 0.225229607157436 no 820 0.215874036236285 1037 11092 Increases levels of cortical cytochrome oxidase. SGTC_529 4076-0302 30.3 µM 0.7858733124769 0.225323005797147 no 821 0.21597085543878 1005 5816522 SGTC_1744 st037937 38.9 µM 0.782902300146717 0.226163503236958 no 822 0.216842243345487 1068 1016152 SGTC_2195 6536160 144.242 µM 0.779018758014937 0.227264821450185 no 823 0.217984332532505 1001 3834386 SGTC_2669 eugenol 100 µM 0.777933868423793 0.22757302014643 no 824 0.218304000310853 1039 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2213 7173844 200 µM 0.777738918835915 0.22762842694574 no 825 0.218361471728509 1095 892728 SGTC_277 nystatin 15.5 µM 0.777332114322623 0.227744069681903 no 826 0.218481426345923 1099 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.777259526087366 0.227764707890041 no 827 0.218502834458242 1019 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_473 2-arachidonoylglycerol 10 µM 0.77708302926743 0.227814893664996 no 828 0.218554892887519 993 5282280 An endocannabinoid. SGTC_113 0099-0221 2.5 µM 0.775723828140625 0.228201582485101 no 829 0.218956033770024 1043 89219 SGTC_834 0312-0008 75.7 µM 0.773374210744046 0.228870911378318 no 830 0.219650473979432 1085 6385573 YIL048W NEO1 SGTC_3198 9112019 49.47 µM 0.772813780598733 0.229030722129278 no 831 0.219816298297654 1081 45595555 SGTC_721 1187-1332 279 µM 0.772088189550538 0.229237722683957 no 832 0.220031098382448 968 25730 SGTC_2496 diffractaic acid 79.83 µM 0.770588350811845 0.229665937184987 no 833 0.220475484109134 1077 94870 An apoptosis inducer which activates caspases. SGTC_2252 omeprazole 400 µM 0.76973416240055 0.229910014085856 no 834 0.220728800449641 1011 4594 A proton pump inhibitor. SGTC_3250 9135583 49.47 µM 0.76859597654581 0.230235466304716 no 835 0.22106659737793 1068 7699353 SGTC_3330 9141424 71.43 µM 0.767160209098038 0.230646376118683 no 836 0.221493133834125 1108 27261020 SGTC_3297 9117502 71.43 µM 0.76652599658646 0.230828015113362 no 837 0.221681694799387 1102 7453720 SGTC_3026 9090633 49.47 µM 0.762082067817266 0.232102998571144 no 838 0.223005512342782 1112 25236842 SGTC_1730 st033808 45.1 µM 0.761799129115488 0.232184307502088 no 839 0.223089950128567 1121 1045166 SGTC_2098 5376439 882.5 nM 0.760599439227552 0.232529241975723 no 840 0.223448177407429 1142 2844116 SGTC_2699 st077704 54.6 µM 0.75824521527843 0.233206955185898 no 841 0.224152098772335 1078 645852 SGTC_2623 humulene 100 µM 0.757262720160866 0.233490111131143 no 842 0.22444624037297 1010 6187145 An anti-inflammatory. SGTC_3116 9124943 49.47 µM 0.756354068052685 0.233752155102227 no 843 0.224718469551878 1052 41905195 YPL160W CDC60 SGTC_1627 st003713 25.6 µM 0.754513539828276 0.234283439713117 no 844 0.225270459136697 1148 16195070 YER133W GLC7 SGTC_1122 capsaicin 818.572 nM 0.753793624607816 0.23449143126324 no 845 0.22548657639014 1107 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2276 7947513 42.08 µM 0.746614103551261 0.236571254620335 no 846 0.227648266306737 1053 2105100 SGTC_1036 k216-0215 33.5 µM 0.746207938948825 0.236689218344492 no 847 0.227770906555086 1120 622330 SGTC_111 0083-0039 52.457 µM 0.744622047100066 0.237150123799975 no 848 0.22825011797273 1044 759313 SGTC_488 nitrendipine 139 µM 0.742862548252342 0.237662060902363 no 849 0.228782451065877 1131 4507 Dihydropyridine L-type calcium channel blocker. SGTC_465 cgp-37157 41 µM 0.742337067419116 0.237815070310117 no 850 0.228941569364263 1027 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1093 fluphenazine 7.97 µM 0.741625601411938 0.238022320909483 no 851 0.22915710385512 1191 6602611 An atypical antipsychotic. SGTC_1757 st041620 31.8375 µM 0.738870570773711 0.238825796638544 no 852 0.229992797048225 1154 5289815 SGTC_3267 9137951 49.47 µM 0.738824059868564 0.238839373777389 no 853 0.230006919990595 1119 16643986 SGTC_2544 sphondin 68.51 µM 0.738818019261775 0.238841137140142 no 854 0.23000875424425 1143 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1330 1469-0054 61.8 µM 0.736631886013176 0.239479776504819 no 855 0.230673119409176 1163 7102664 SGTC_760 0568-0725 82.9 µM 0.736217097763272 0.239601054560537 no 856 0.230799294316308 1156 3916171 SGTC_811 0416-0114 265 µM 0.735534315991852 0.23980076301977 no 857 0.231007074398593 1147 6612453 SGTC_2646 retinol 96.75 µM 0.734773623778022 0.240023366595778 no 858 0.231238686640532 1145 445354 A vitamin A analog and teratogen. SGTC_2481 5478948 45.16 µM 0.732600907890732 0.240659794798248 no 859 0.231900938607915 1130 77792 SGTC_2865 9030313 51.95 µM 0.731537598818357 0.240971591905385 no 860 0.23222542377985 1091 42562754 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.72936982368425 0.241607934658862 no 861 0.232887735750755 1134 4330530 SGTC_2122 5258151 111.688 µM 0.727860728121271 0.242051462427455 no 862 0.233349422716258 1135 2173356 SGTC_3251 9135047 49.47 µM 0.727813322076093 0.242065402357476 no 863 0.233363934164258 1122 17682963 SGTC_3084 9116877 49.47 µM 0.726902318752269 0.242333370940274 no 864 0.233642898319253 1068 27241325 SGTC_1185 1319-0113 81.3 µM 0.725987617745043 0.2426025888296 no 865 0.233923180686143 1137 4672763 SGTC_3253 9135987 49.47 µM 0.723193146732427 0.243426069204775 no 866 0.23478061434208 1134 4182430 SGTC_188 3229-0966 278.469 µM 0.72270582446852 0.243569828804446 no 867 0.234930318208639 1255 5722370 SGTC_3271 9137798 49.47 µM 0.722568882471754 0.243610234813334 no 868 0.234972395851408 1098 6498326 SGTC_1798 st045719 60.953 µM 0.722093082312418 0.243750652205277 no 869 0.235118625507234 1116 3980186 SGTC_405 ebelactone b 50 µM 0.721498710546808 0.243926123624588 no 870 0.235301366862392 1128 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2532 xanthone 78.9 µM 0.721218903888715 0.244008752199656 no 871 0.235387421383237 1051 7020 An insecticide. SGTC_1223 0764-0573 147 µM 0.720975384715025 0.244080677151043 no 872 0.235462329825752 1201 1609797 SGTC_194 1486-1323 56.904 µM 0.71881223053126 0.244720080238065 no 873 0.23612831041945 1158 5178754 SGTC_1388 3346-4487 254 µM 0.716875620457343 0.245293283753009 no 874 0.236725423063675 1208 3345614 SGTC_335 4077-0256 27.6 µM 0.713395731022642 0.246325082597858 no 875 0.237800456994414 1197 3121989 SGTC_1939 st074455 53.6 µM 0.713337928204245 0.246342240948059 no 876 0.237818336460093 1175 1644229 SGTC_2569 tetrandrine 100 µM 0.713014445427419 0.24643827630365 no 877 0.237918409187963 1109 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1675 st018485 24.5 µM 0.710814264942531 0.247091996403203 no 878 0.238599669864155 1166 3323024 SGTC_2798 7813637 45.45 µM 0.709374799934181 0.24752019331174 no 879 0.239045960818379 1149 956368 SGTC_1759 st043059 70 µM 0.705006543046405 0.248822039815509 no 880 0.240403082158056 1188 669426 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.704815799762386 0.248878968884445 no 881 0.24046243737672 1167 803109 SGTC_2541 muurolladie-3-one 83.07 µM 0.703070638133102 0.249400149992046 no 882 0.241005864619465 1204 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_578 3460-0051 92 µM 0.701957673477255 0.249732832308213 no 883 0.241352780026381 1243 2876744 SGTC_2248 tofa 1.1 µM 0.701168858315741 0.249968763958638 no 884 0.241598820972493 1129 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_193 1273-0060 1.558 µM 0.699526463800623 0.250460377266776 no 885 0.242111540267659 1077 2847393 YHR072W ERG7 SGTC_1609 st001574 46.4 µM 0.69823568004306 0.250847103207811 no 886 0.242514908120494 1187 3960012 SGTC_2636 apigenin dimethyl ether 100 µM 0.69708002661327 0.251193611370567 no 887 0.242876356559646 1198 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_319 1348-1596 45.5 µM 0.696148829949635 0.251473003048605 no 888 0.243167814617466 1231 5380505 SGTC_2946 9065502 71.43 µM 0.695377632956373 0.251704513468665 no 889 0.243409336978577 1023 16489101 SGTC_2119 5528445 120.635 µM 0.694778980866235 0.251884304130508 no 890 0.243596911299342 1187 791935 SGTC_1678 st019265 80.2 µM 0.694766720601485 0.251887986912417 no 891 0.243600753596226 1208 5367020 SGTC_2828 7998861 71.43 µM 0.694766491441083 0.251888055748704 no 892 0.243600825414097 1124 2988188 SGTC_2327 6189656 200 µM 0.692191534421521 0.252662160005747 no 893 0.244408527168245 1222 5349088 SGTC_781 4335-2806 94.4 µM 0.690665213695054 0.253121605576878 no 894 0.244887977440901 1274 845254 SGTC_2740 felodipine 17.08 µM 0.686487142999042 0.254381512291332 no 895 0.246202984576107 1166 3333 L-type calcium channel blocker SGTC_3086 9117350 49.47 µM 0.686235791411748 0.254457412611716 no 896 0.246282215615911 1144 2679265 SGTC_611 3453-1652 23.7 µM 0.685445969216985 0.254695991429339 no 897 0.246531272282362 1214 1560575 SGTC_3351 9150312 21.596 µM 0.684961905032358 0.254842268871416 no 898 0.246683980153098 1194 4904905 SGTC_1256 0570-0116 285 µM 0.684861957961144 0.254872476957841 no 899 0.246715516793198 1207 410638 SGTC_312 4092-0653 6.84 µM 0.684318522381293 0.25503675817425 no 900 0.246887026648966 1218 1148278 SGTC_527 4476-4215 268 µM 0.683780439119676 0.255199475941379 no 901 0.247056910151661 1183 4418754 SGTC_332 4112-0506 40.9 µM 0.678809775507117 0.256705180563578 no 902 0.248629199527497 1234 2790355 SGTC_2239 6685329 187.64 µM 0.678770788971173 0.256717008550385 no 903 0.248641552536748 1229 805680 SGTC_236 1509-0011 5.31 µM 0.67862421041851 0.256761481036004 no 904 0.248687999347295 1303 3107280 SGTC_3202 9113761 49.47 µM 0.677630135947259 0.257063192773464 no 905 0.249003116769313 1253 4798415 SGTC_2151 5563267 85.4165 µM 0.677039800814146 0.257242452731823 no 906 0.249190351023131 1228 5310824 SGTC_1291 0993-0025 5.79 µM 0.674490759476595 0.258017234835166 no 907 0.249999679274407 1241 4353356 SGTC_3014 9081533 49.47 µM 0.674262228629387 0.258086755947776 no 908 0.250072306571028 1239 21367265 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.674202427386342 0.25810494962021 no 909 0.250091313304281 1229 688798 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.672506691206956 0.25862112975649 no 910 0.250630590906185 1245 6708739 YPR165W RHO1 SGTC_429 1112-0049 25.5 µM 0.6695849785667 0.25951174787888 no 911 0.251561196228831 1206 2836170 SGTC_1038 k292-0204 154 µM 0.669471962244282 0.259546230143637 no 912 0.251597230106223 1200 4454212 SGTC_2761 levamisole 97.89 µM 0.669343862630094 0.259585317312541 no 913 0.251638076403975 1267 26879 An alkaline phosphatase inhibitor. SGTC_2255 7941087 197.44 µM 0.668615814036099 0.259807525248258 no 914 0.251870291072337 1261 935561 SGTC_1924 st058459 75.1 µM 0.668318566207639 0.259898276556644 no 915 0.251965132233331 1206 688683 SGTC_1867 st057372 64 µM 0.667445212271836 0.260165010626752 no 916 0.25224389726278 1248 688837 SGTC_3278 9139605 49.47 µM 0.667212202793732 0.260236198700739 no 917 0.252318298814263 1264 7958859 SGTC_3154 9100113 49.47 µM 0.666063090483568 0.260587417412191 no 918 0.252685387540372 1229 25237525 SGTC_1480 1070-0044 41.2 µM 0.662924420857464 0.261547973363658 no 919 0.253689480178529 1247 3124987 SGTC_447 ml7 120 µM 0.662352797857704 0.26172310786352 no 920 0.253872573537049 1274 4216 Selective myosin light chain kinase inhibitor. SGTC_716 1683-5115 658 µM 0.65895469928626 0.262765461704972 no 921 0.254962429495616 1277 723597 SGTC_1072 oxiconazole 14.9 nM 0.658394676255489 0.262937450227503 no 922 0.255142277701866 1276 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2429 5902844 64.44 µM 0.65753686686276 0.263201003383524 no 923 0.255417886894329 1270 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_410 α-linolenic acid 100 µM 0.655656717161947 0.263779131790675 no 924 0.25602251186952 1285 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2143 5623677 140.463 µM 0.65426676695002 0.264206944391748 no 925 0.256469976360936 1219 5375313 SGTC_1657 st012939 43.4 µM 0.653710254341399 0.26437833235151 no 926 0.256649247750566 1291 24207257 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.652454085306345 0.264765399891387 no 927 0.257054141703755 1269 5106787 A p450 inhibitor. SGTC_1445 4239-0156 97.7 µM 0.652246292031362 0.26482945568609 no 928 0.257121150560216 1322 4008346 SGTC_2449 5812982 45.77 µM 0.650452178584218 0.265382848989267 no 929 0.257700091086328 1239 776185 SGTC_2770 toltrazuril 17.5 µM 0.649391971417771 0.265710144953704 no 930 0.258042526030628 1248 68591 Kills coccidiodes. SGTC_413 propylparaben 100 µM 0.649387538102121 0.265711513989664 no 931 0.258043958436843 1240 7175 A pharmaceutical preservative. SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.648887950602643 0.265865812680087 no 932 0.258205401787642 1313 165506 SGTC_656 4090-1979 187 µM 0.648485155831976 0.265990249779403 no 933 0.258335604364227 1283 22330961 SGTC_2876 9059903 25.97 µM 0.648401529679978 0.266016088459851 no 934 0.258362640609313 1258 6916095 SGTC_877 0771-0151 33.1 µM 0.647716035487908 0.266227939320827 no 935 0.258584315397337 1292 6166523 SGTC_2709 st078560 56 µM 0.647678609110879 0.266239508339831 no 936 0.25859642115622 1291 17250903 SGTC_2050 5263056 171 µM 0.647454512760873 0.266308784993625 no 937 0.258668912440187 1272 763468 YGL055W OLE1 SGTC_169 k015-0017 16.025 µM 0.647332026423853 0.266346654006518 no 938 0.258708539092612 1327 1840002 SGTC_3176 9106582 49.47 µM 0.647151137935065 0.266402584153928 no 939 0.258767065694881 1184 17018027 SGTC_2062 5245942 200 µM 0.642490275338531 0.267845754162317 no 940 0.260277450722808 1335 1376160 SGTC_2060 5238662 140 µM 0.641933974069151 0.26801826766685 no 941 0.260458026995438 1250 790130 SGTC_2774 tamoxifen 10.92 µM 0.640042557580292 0.268605229283348 no 942 0.261072466017856 1310 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1630 st005209 31.3 µM 0.639305561287739 0.268834115472569 no 943 0.261312085665321 1280 3367314 SGTC_2696 st077691 74.316 µM 0.635875674503668 0.269900609641358 no 944 0.262428729411277 1298 757133 SGTC_95 0471-0001 561.058 µM 0.634268543012094 0.270401061183288 no 945 0.26295279104424 1216 4015405 SGTC_107 0358-0022 2.6945 µM 0.634119876357495 0.270447378552423 no 946 0.263001296044977 1301 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1971 st069429 63.5 µM 0.633891953718096 0.270518395966759 no 947 0.263075668525343 1278 1246522 YGL099W LSG1 SGTC_1531 st059297 52.4 µM 0.633755728786216 0.270560846143087 no 948 0.263120124642257 1305 7566702 SGTC_2667 digitoxin 100 µM 0.633181501815335 0.270739822322419 no 949 0.2633075620479 1262 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2474 5321570 43.32 µM 0.632054941907473 0.271091122357376 no 950 0.26367548828181 1330 2841384 SGTC_2134 5324836 1.464 µM 0.630754927275732 0.271496793861394 no 951 0.264100389250663 1298 699272 SGTC_658 3253-0951 102 µM 0.630403089662079 0.271606637282277 no 952 0.26421544493986 1305 1184878 SGTC_2786 7743617 45.45 µM 0.629463811133181 0.271899987634829 no 953 0.264522726796678 1219 583674 SGTC_304 1310-0298 97 µM 0.629084922208722 0.27201836475692 no 954 0.264646730500629 1242 1550234 SGTC_1514 1189-1591 158 µM 0.628545590849351 0.272186913465628 no 955 0.264823295185364 1373 767698 YMR146C TIF34 SGTC_2968 9090663 33.37 µM 0.627996081043156 0.272358696453426 no 956 0.26500325362924 1294 25236811 SGTC_3011 9081274 71.4286 µM 0.627442802064669 0.272531712122206 no 957 0.265184509188786 1293 6625322 SGTC_2588 indole-3-carbinol 100 µM 0.626711938486196 0.272760343826998 no 958 0.265424038371594 1301 3712 Induces cell cycle arrest. SGTC_48 0382-0018 55 µM 0.626289438731421 0.272892555303547 no 959 0.265562556162593 1402 762596 SGTC_1404 3909-7820 48.3 µM 0.625159028101457 0.273246447229008 no 960 0.265933344826525 1283 23741373 SGTC_358 0075-0058 9.45 µM 0.623372958758892 0.273806065889758 no 961 0.266519731812186 1341 1069125 SGTC_2313 7726885 200 µM 0.621260477003048 0.27446868821269 no 962 0.267214126856791 1306 726423 SGTC_3093 9117344 49.47 µM 0.620679095362969 0.274651189000943 no 963 0.267405393239313 1317 24824913 SGTC_154 3389-1638 511.116 µM 0.620300953519276 0.274769923151462 no 964 0.267529833641128 1215 5238686 SGTC_2375 9072683 200 µM 0.619918977504149 0.274889886894279 no 965 0.267655565444963 1368 16798029 SGTC_1995 st072814 61.1 µM 0.619870550867245 0.274905097652389 no 966 0.267671507757158 1251 5769371 SGTC_2026 5148700 152 µM 0.618379168325505 0.275373742391006 no 967 0.268162713202638 1292 79838 SGTC_878 0828-0289 13.7 µM 0.615917959337066 0.276147999321938 no 968 0.268974333894297 1328 745350 YLR208W SEC13 SGTC_3114 9122766 49.47 µM 0.615529284789288 0.276270367738194 no 969 0.269102617826655 1252 17176985 SGTC_3144 9087057 49.47 µM 0.615029502557053 0.27642775585242 no 970 0.269267618501227 1276 17249618 SGTC_464 bw-b 70c 158 µM 0.614841100615788 0.276487097555641 no 971 0.269329831652916 1344 5353454 SGTC_1301 naphtanilide LB 4.81 µM 0.613104739528453 0.277034299936716 no 972 0.269903543285856 1384 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2071 5230951 39.92 µM 0.609952496365181 0.278029060582217 no 973 0.270946637912179 1339 1799272 SGTC_3133 9127736 49.47 µM 0.609857588109161 0.278059038004362 no 974 0.270978074740596 1342 27243420 SGTC_2711 st079103 59.1 µM 0.60905676472404 0.278312046318916 no 975 0.271243407001363 1326 54693780 SGTC_1986 st071812 45 µM 0.608388939193835 0.278523121703085 no 976 0.271464772827959 1323 11838594 SGTC_265 mycophenolic acid 32.932 µM 0.607550328797897 0.278788286372339 no 977 0.271742876549126 1410 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_489 paxilline 115 µM 0.604498500144887 0.279754296120199 no 978 0.272756133042637 1283 105008 A toxic potassium channel blocker. SGTC_3054 9094397 49.47 µM 0.602748724048136 0.280308892571068 no 979 0.273337931309529 1309 2598354 SGTC_771 0250-0039 27.3 µM 0.602220395680805 0.280476452331948 no 980 0.273513720524517 1348 3005115 SGTC_523 1934-0222 13.7 µM 0.601810731893655 0.280606410890103 no 981 0.273650065312702 1333 1361595 SGTC_3315 9136395 68.55 µM 0.60151082175308 0.280701570522484 no 982 0.273749903077606 1361 16876844 SGTC_922 1866-0035 480 µM 0.601081173061993 0.280837922586518 no 983 0.273892961186114 1368 3156169 SGTC_685 1278-0033 54.9 µM 0.59881416663105 0.281557902942212 no 984 0.274648407118433 1419 3590572 SGTC_588 3970-1144 52.9 µM 0.598244725544344 0.28173889198748 no 985 0.274838326189438 1293 1888707 SGTC_3237 9133362 49.47 µM 0.597115326739051 0.28209802175173 no 986 0.275215192859741 1361 43845137 SGTC_1364 1653-0028 37.6 µM 0.596742279157154 0.282216692995304 no 987 0.275339730181244 1336 5718652 SGTC_1516 st013856 110 µM 0.596489791838213 0.282297026097402 no 988 0.27542403568441 1324 5281404 A mutagen and neurotoxin. SGTC_1676 st018489 23.4 µM 0.596426297843291 0.282317229514778 no 989 0.27544523832437 1364 3696235 SGTC_88 0180-0332 8.668 µM 0.593161011147989 0.283357161311362 no 990 0.27653670132809 1375 3101745 SGTC_816 0325-0417 81.3 µM 0.592326910054392 0.283623100883394 no 991 0.276815849676972 1328 68101 SGTC_2751 anetholtrithion 17.25 µM 0.589555506132738 0.284507575582447 no 992 0.277744344499419 1364 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1412 3909-8563 178 µM 0.589200355394904 0.28462101468659 no 993 0.277863439393394 1419 23767530 SGTC_2408 sulbentine 18.36 µM 0.589151643927719 0.284636575356145 no 994 0.277879776054921 1435 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1102 cgs 12066b 26.1 µM 0.58906947887036 0.284662823552137 no 995 0.277907333313179 1338 6438352 A 5-HT1B full agonist. SGTC_966 1300-0360 30.2 µM 0.586933566251623 0.285345560742399 no 996 0.278624162613633 1361 70588 SGTC_3254 9136651 49.47 µM 0.586541614671683 0.285470931372866 no 997 0.278755802396439 1328 16454030 SGTC_3107 9121808 49.47 µM 0.58505867820308 0.285945504373454 no 998 0.279254131147673 1320 662681 SGTC_626 0214-0009 33 µM 0.58468027020521 0.28606666346838 no 999 0.279381361378311 1435 3437874 SGTC_896 0964-0007 44.5 µM 0.584555305538302 0.28610668015202 no 1000 0.279423383808171 1345 6756758 SGTC_875 0709-0210 25.7 µM 0.584164591807226 0.286231813213413 no 1001 0.279554790671109 1384 6251364 SGTC_2093 5331342 194.4 µM 0.582762286053431 0.286681140621773 no 1002 0.280026668326972 1380 33839 SGTC_2955 9076254 12.21 µM 0.580398228102375 0.287439389372845 no 1003 0.28082304987858 1318 16459619 SGTC_2514 salinomycin 42.74 µM 0.579676586690582 0.287671037701369 no 1004 0.281066367606445 1435 23682228 A polyether potassium ionophore. SGTC_3230 9131665 49.47 µM 0.579315573257334 0.28778695682973 no 1005 0.281188129662329 1325 15943720 SGTC_987 1497-1013 404 µM 0.5786608193222 0.287997250456533 no 1006 0.281409029037685 1360 1676435 SGTC_1307 1187-1599 12.2 µM 0.578308406340256 0.288110468348812 no 1007 0.281527959975692 1354 1538471 SGTC_2043 5101342 149 µM 0.57694634561024 0.288548247874682 no 1008 0.281987850650196 1345 678451 SGTC_1987 st072290 61.9 µM 0.575851512476561 0.288900364918042 no 1009 0.28235777584613 1404 54697379 SGTC_814 3342-0569 96 µM 0.575047613164343 0.289159041355317 no 1010 0.282629548090018 1410 4346283 SGTC_2349 9023730 187.07 µM 0.573728248831417 0.289583818535025 no 1011 0.283075854620572 1458 4126287 SGTC_2386 9075165 157.42 µM 0.573674453167457 0.28960114458292 no 1012 0.283094059464617 1344 16452277 SGTC_1928 4'-methoxychalcone 40.3 µM 0.571781796389721 0.290211024836543 no 1013 0.283734905630648 1517 641818 SGTC_1043 0916-0009 19.3 µM 0.571479258398189 0.290308568916603 no 1014 0.283837408172387 1441 3101130 SGTC_938 3126-1755 342 µM 0.571199221763265 0.29039887180731 no 1015 0.283932302851396 1388 1777771 SGTC_2104 5389443 200 µM 0.569775574112162 0.290858156052936 no 1016 0.284414962188961 1474 2244536 SGTC_184 1494-0393 24.714 µM 0.568398256474913 0.29130281661219 no 1017 0.284882287026886 1350 3090647 SGTC_102 gallobenzophenone 83.616 µM 0.567410936609557 0.291621763319547 no 1018 0.285217510599177 1454 70837 SGTC_1948 st076329 66.6 µM 0.565066021523157 0.292379923338751 no 1019 0.286014429384632 1311 24208413 SGTC_590 k048-0076 22.4 µM 0.564933407306853 0.292422827651908 no 1020 0.28605952988818 1450 6832814 SGTC_2720 fluspirilene 36.88 µM 0.564863998319678 0.292445284517691 no 1021 0.286083136398896 1387 3396 An atypical antipsychotic. SGTC_1874 staurosporine 7.6 µM 0.564852408702205 0.292449034347735 no 1022 0.286087078203831 1445 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1828 st055811 49 µM 0.564759150985617 0.292479208770348 no 1023 0.286118797508917 1366 5877589 SGTC_2978 9011784 42.97 µM 0.562129295227553 0.29333071881022 no 1024 0.287013965009862 1485 2994934 SGTC_3041 9091929 49.47 µM 0.562023980823821 0.293364842033832 no 1025 0.287049840222109 1429 25236887 SGTC_544 k015-0020 52.4 µM 0.559733979931642 0.294107286234796 no 1026 0.287830450630007 1404 3008304 SGTC_1743 st037606 46.3785 µM 0.559674240495987 0.294126666052806 no 1027 0.287850827888255 1434 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1438 4092-1045 4 µM 0.559478459268385 0.294190182749751 no 1028 0.287917614088107 1381 1351342 SGTC_1262 0737-0114 49.6 µM 0.559019450533704 0.294339122371366 no 1029 0.288074222892423 1412 765919 SGTC_1806 st050005 60.3 µM 0.558596459560411 0.294476405733699 no 1030 0.288218578410933 1358 5194765 SGTC_1683 st010134 710 nM 0.557739374954504 0.294754666440819 no 1031 0.288511183058125 1368 3818134 SGTC_2860 9025725 38.96 µM 0.557167443812802 0.294940416769773 no 1032 0.288706515494328 1346 40546248 SGTC_278 4092-0821 23.9 µM 0.556316820265353 0.295216779826846 no 1033 0.288997145270682 1417 877900 SGTC_2493 resveratrol 26.09 µM 0.552857835475298 0.296341811574475 no 1034 0.290180380849812 1362 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2847 9005661 71.43 µM 0.551013271849221 0.296942556790174 no 1035 0.290812288305142 1340 2991449 SGTC_683 panaxydol 45 µM 0.550382167754537 0.297148225271069 no 1036 0.291028638481684 1395 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_3200 9114385 49.47 µM 0.547257157828857 0.298167582948339 no 1037 0.292101036340468 1368 17018030 YLR208W SEC13 SGTC_2639 lactacystin 53 µM 0.546930205638839 0.298274324580889 no 1038 0.292213341484594 1466 3870 A proteasome inhibitor. SGTC_2728 chlorpromazine 9.18 µM 0.54578159744938 0.298649453999015 no 1039 0.292608037252778 1419 2726 A thorazine and dopamine antagonist. SGTC_2040 5100729 123 µM 0.544417253869995 0.299095319993592 no 1040 0.293077187661571 1446 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1724 st037281 8.293 µM 0.543039462102512 0.299545887255187 no 1041 0.293551316205886 1411 574124 YDL195W SEC31 SGTC_1103 duloxetine 36.1 µM 0.542385298402722 0.299759920368634 no 1042 0.293776552650639 1533 60835 A selective serotonin reuptake inhibitor. SGTC_1419 3993-2473 62.6 µM 0.54231660080816 0.299782401268202 no 1043 0.293800210699167 1455 704026 SGTC_2144 5628481 200 µM 0.541409350060328 0.300079365538243 no 1044 0.294112731981672 1416 2818399 SGTC_3313 9133968 57.047 µM 0.540585167809604 0.300349254846638 no 1045 0.294396771708962 1389 1494643 SGTC_3338 9144300 39.5675 µM 0.539313690311977 0.300765831853667 no 1046 0.294835211989984 1439 4901274 SGTC_2694 st077685 81.9 µM 0.534864052075206 0.302225724869916 no 1047 0.296371933795461 1369 2838096 SGTC_2431 5490079 200 µM 0.533430366678274 0.302696782808887 no 1048 0.296867850705974 1424 5722345 SGTC_1845 st056753 3.01 µM 0.531427207421675 0.303355499790364 no 1049 0.297561385896543 1369 5375839 SGTC_250 brefeldin a 552.239 µM 0.52989419304888 0.30386004706967 no 1050 0.298092646277934 1388 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_297 0986-0032 24 µM 0.528794765240276 0.304222122203755 no 1051 0.298473914755005 1401 2847425 SGTC_2365 9042475 200 µM 0.527669650794415 0.304592855568234 no 1052 0.298864320603457 1422 6464479 SGTC_501 nsc-95397 161 µM 0.526986306105796 0.304818120643313 no 1053 0.299101549018876 1503 262093 SGTC_2275 7947463 200 µM 0.526694482392803 0.304914343099806 no 1054 0.299202883927784 1415 1225414 SGTC_33 0986-0033 35.816 µM 0.52441972655875 0.305664855932255 no 1055 0.299993319519674 1440 2848082 SGTC_253 dyclonine 31.25 µM 0.52323021928029 0.306057637034341 no 1056 0.300407027172397 1499 3180 An oral anasthetic. SGTC_357 1325-0123 420 µM 0.520624003616528 0.306919001588955 no 1057 0.301314362249975 1479 1098503 SGTC_502 l-744,832 89.3 µM 0.519391916890139 0.307326582858852 no 1058 0.30174373345205 1501 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_979 1426-2828 121 µM 0.518950560894898 0.307472643866405 no 1059 0.30189760895737 1523 747872 SGTC_1197 1601-0112 267 µM 0.517592843955483 0.307922153931166 no 1060 0.302371187833084 1424 7350313 SGTC_2502 avocadyne acetate 18.59 µM 0.515427586543351 0.308639619290182 no 1061 0.303127129681217 1408 3952079 SGTC_1045 1348-1485 165 µM 0.515305146660825 0.308680212024794 no 1062 0.303169901539735 1442 6810614 SGTC_1319 1306-0155 43.7 µM 0.514532540407914 0.30893640959675 no 1063 0.303439857891106 1487 3122360 SGTC_2308 7584454 197.62 µM 0.513597830955314 0.309246485160094 no 1064 0.303766598191695 1562 893577 SGTC_536 3852-0578 10.6 µM 0.51185703549136 0.309824329577601 no 1065 0.304375534765551 1559 2869208 SGTC_1946 st076057 65.1 µM 0.510100821888904 0.310407768468305 no 1066 0.304990414716684 1397 953009 SGTC_186 3455-3465 67.277 µM 0.508776570691269 0.310848019160703 no 1067 0.305454421868203 1449 755278 SGTC_1616 st002734 56.1 µM 0.508725795678831 0.310864904839954 no 1068 0.305472219260314 1481 4026101 SGTC_2329 6138490 200 µM 0.507963367389359 0.311118504983817 no 1069 0.305739516901767 1495 720019 SGTC_2716 st080858 38.6235 µM 0.507848960680534 0.311156566873075 no 1070 0.305779635372757 1458 5296050 SGTC_1328 1441-0025 69.2 µM 0.507813589445155 0.311168334913768 no 1071 0.305792039311897 1377 4562601 SGTC_1144 3486-0183 12.5 µM 0.507564508634481 0.311251209780688 no 1072 0.305879392956888 1465 6744069 SGTC_2183 6420625 130.508 µM 0.506461712942593 0.311618249980056 no 1073 0.306266280496126 1454 2897619 SGTC_2479 5617353 43.85 µM 0.505177861113991 0.312045786443415 no 1074 0.306716959195116 1534 2731746 SGTC_1652 st011932 78 µM 0.504971044479344 0.312114682310797 no 1075 0.306789586717178 1534 1551076 SGTC_2920 7982904 15.77 µM 0.504489576382742 0.312275097002682 no 1076 0.306958692607244 1434 6456808 SGTC_2991 9074669 71.4286 µM 0.50356068341364 0.312584684478522 no 1077 0.307285063452021 1567 17333109 SGTC_1749 st037932 54.2 µM 0.502473406120448 0.312947227359634 no 1078 0.307667277317974 1462 594497 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.500591120115636 0.313575286459881 no 1079 0.308329456593336 1436 390807 SGTC_1910 st062352 60.4 µM 0.498328240927419 0.31433105328119 no 1080 0.309126352910516 1381 2245730 SGTC_1127 asiatic acid 681.4 nM 0.49589098395825 0.315145930996038 no 1081 0.309985663811394 1462 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_3142 9086498 49.47 µM 0.495806071874505 0.315174336936205 no 1082 0.310015620271498 1450 25236367 SGTC_365 0121-0052 13.6 µM 0.49385416389429 0.315827616656116 no 1083 0.310704588769554 1527 3101739 SGTC_1976 st070609 63.5 µM 0.493651853639251 0.315895360385368 no 1084 0.310776036624615 1459 682556 SGTC_2598 perillyl alcohol 100 µM 0.490503960477118 0.316950230087194 no 1085 0.311888663987756 1544 10819 An apoptosis inducer. SGTC_1550 gossypolone 36.6 µM 0.490312042503014 0.31701459071456 no 1086 0.311956553361534 1485 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_343 4130-2827 29.8 µM 0.490164520151217 0.317064066817461 no 1087 0.31200874249916 1477 1118244 SGTC_2523 spermine 47.74 µM 0.490163498584843 0.317064409442187 no 1088 0.312009103912929 1558 1103 A DNA binding polyamine. SGTC_785 1270-0111 65.3 µM 0.488743743640471 0.317540734712657 no 1089 0.312511565172025 1461 6741994 SGTC_1236 0330-0013 258 µM 0.488234466608157 0.317711669950169 no 1090 0.31269188692865 1486 4617066 SGTC_852 0418-0143 439 µM 0.488153850444957 0.317738731759359 no 1091 0.312720435127992 1517 5369229 SGTC_179 1273-0063 6.77 µM 0.487309563735194 0.318022206423455 no 1092 0.313019485633997 1459 3108139 SGTC_1625 st003711 30.1 µM 0.482105193682674 0.3197719567608 no 1093 0.314865610267535 1583 24207034 YER133W GLC7 SGTC_2890 9046729 58.44 µM 0.480229663326449 0.320403512002118 no 1094 0.315532048234253 1433 903329 SGTC_1326 1431-2094 10.8 µM 0.478511080286332 0.320982674777731 no 1095 0.316143244917816 1480 616278 SGTC_2359 9039622 200 µM 0.477589994662375 0.321293260275417 no 1096 0.316471026763255 1566 6463596 SGTC_904 1141-0088 396 µM 0.47548750046956 0.322002678983778 no 1097 0.317219770186148 1428 1378119 SGTC_384 k007-0144 5.16 µM 0.475326539527684 0.322057016833275 no 1098 0.317277122735043 1536 6824886 SGTC_1116 jasmonic acid  1.58368 µM 0.474887528198719 0.322205239398074 no 1099 0.317433570679724 1562 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2629 bisabolol 100 µM 0.473043300299265 0.322828211268745 no 1100 0.31809114364794 1595 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_3331 9141060 1.957 µM 0.471994106660221 0.323182846302372 no 1101 0.318465497565617 1472 4906567 YPR165W RHO1 SGTC_1430 4049-0248 69.1 µM 0.471626481684308 0.323307144250121 no 1102 0.318596710612848 1615 22774488 SGTC_615 k087-0205 167 µM 0.469834624114283 0.323913272691257 no 1103 0.319236587532814 1464 9642773 SGTC_1356 1502-0781 85.8 µM 0.469294573851542 0.32409604622501 no 1104 0.319429546626261 1519 567702 SGTC_895 0964-0006 13.7 µM 0.469046460908064 0.324180031294332 no 1105 0.319518213383123 1507 6738897 SGTC_155 k072-0202 43.6 µM 0.46821832398278 0.324460416517185 no 1106 0.319814234796526 1484 5857737 SGTC_2235 salicylic acid 500 µM 0.466899480931047 0.324907147277649 no 1107 0.320285898340965 1547 338 A COX inhibitor and kinase inhibitor. SGTC_2568 diosmetin 100 µM 0.463866271413939 0.325935539228653 no 1108 0.321371779582205 1536 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_223 busulfan 5 mM 0.46060072654254 0.327044185032389 no 1109 0.322542545125011 1577 2478 A DNA alkylator. SGTC_951 1171-0579 82.7 µM 0.459810849472608 0.327312576558533 no 1110 0.322825997491134 1460 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_566 0958-0068 16.5 µM 0.459738075861823 0.327337308724468 no 1111 0.322852117942602 1566 6815365 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.458991078765273 0.32759122004939 no 1112 0.323120286261596 1577 77254 SGTC_166 k072-0058 166.424 µM 0.456162851828776 0.328553282754432 no 1113 0.324136438170693 1571 5846229 SGTC_746 1095-0025 46.6 µM 0.455869741967982 0.328653053523102 no 1114 0.324241824563018 1639 6749286 SGTC_2827 7993847 71.43 µM 0.454780557663125 0.329023904622198 no 1115 0.324633559442252 1575 2985692 SGTC_282 k297-0036 65.7 µM 0.452375468752054 0.329843397624101 no 1116 0.325499258136106 1582 5061378 SGTC_3293 9120939 62.045 µM 0.451718241827441 0.330067478853834 no 1117 0.325735987514829 1601 934087 SGTC_3132 9126706 49.47 µM 0.451441478476108 0.330161859446767 no 1118 0.325835697127964 1577 850858 SGTC_415 dibenzyl ketone 100 µM 0.44766516087225 0.331450719984969 no 1119 0.327197434351718 1654 7593 SGTC_2197 6588183 93.1375 µM 0.446366919514093 0.331894273342025 no 1120 0.327666112164804 1551 884136 SGTC_2270 7924575 90.91 µM 0.445092169907455 0.332330029952687 no 1121 0.328126573574074 1684 1262135 SGTC_1499 4480-0877 67.3 µM 0.444735912440418 0.332451852510492 no 1122 0.328255306626856 1562 2861909 SGTC_2302 7771753 200 µM 0.444486692092536 0.332537084153241 no 1123 0.328345374118466 1505 2203047 SGTC_1777 st045864 34.765 µM 0.441116173930022 0.333690626974276 no 1124 0.329564447469349 1561 4691462 SGTC_1373 2887-0003 58.5 µM 0.44092729757249 0.333755315621528 no 1125 0.329632815408435 1550 776948 SGTC_854 0422-0053 192 µM 0.440901531021442 0.33376414084302 no 1126 0.329642142617982 1534 3596728 SGTC_1898 st060199 18.6 µM 0.440815869302307 0.333793481233846 no 1127 0.3296731519847 1539 688866 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.439659946093185 0.334189501147743 no 1128 0.330091708252973 1712 5024745 SGTC_80 0159-0065 512.242 µM 0.438759273873897 0.334498199958898 no 1129 0.330417986420974 1574 1548079 SGTC_1564 D-Arginine 115 µM 0.436526070673153 0.33526409647895 no 1130 0.331227544074055 1476 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1540 guanosine 70.6 µM 0.436500774941414 0.3352727758018 no 1131 0.331236718548931 1602 6802 Guanosine is a purine nucleoside SGTC_45 0kpi-0036 14.9 µM 0.436369044538116 0.335317975785034 no 1132 0.331284497308764 1608 2795021 SGTC_2240 6690706 185.951 µM 0.436257921226617 0.335356106815577 no 1133 0.331324803989803 1499 805876 SGTC_3105 9121040 49.47 µM 0.436125797401604 0.335401446203185 no 1134 0.331372730526273 1515 41448907 SGTC_522 1273-0010 11.6 µM 0.433193941817824 0.336408152577535 no 1135 0.332436939848301 1623 5705015 SGTC_164 4100-3994 89.624 µM 0.432529739412854 0.336636382011976 no 1136 0.332678221201957 1701 4615967 SGTC_1351 1496-0003 46.5 µM 0.432305690337355 0.336713382054361 no 1137 0.332759625985725 1632 3891978 SGTC_1157 4092-0394 27.6 µM 0.430733996684799 0.337253725997283 no 1138 0.33333089816759 1654 3659885 SGTC_1814 st052110 31.539 µM 0.430572011412507 0.337309435197673 no 1139 0.3333897978607 1679 674163 SGTC_1010 4112-3296 15.2 µM 0.427951120115134 0.33821129460379 no 1140 0.334343353919664 1742 704384 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.427277590114017 0.338443209299295 no 1141 0.334588576667649 1592 165521 SGTC_1912 st060209 90.8 µM 0.42689639058459 0.338574493830448 no 1142 0.334727397309082 1528 688787 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.425427961109577 0.339080401912389 no 1143 0.335262363214944 1691 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1999 st074831 12.5 µM 0.42535841298503 0.339104370065029 no 1144 0.33528770870323 1565 17112523 SGTC_1426 4048-4480 71.7 µM 0.425175162354678 0.339167526274748 no 1145 0.335354494492732 1660 14224343 SGTC_2853 9015042 58.44 µM 0.424515380742583 0.339394953391795 no 1146 0.335594995334365 1497 6457456 SGTC_1548 st061468 90.8 µM 0.424019236378976 0.339566013198913 no 1147 0.335775892192424 1635 390799 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.422795849838239 0.339987951506582 no 1148 0.336222107945819 1579 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1689 st020265 53.493 µM 0.422511048836139 0.340086206368436 no 1149 0.336326018886539 1689 5758320 YPR016C TIF6 SGTC_397 arbidol 50 µM 0.42226889601839 0.340169756372563 no 1150 0.336414379279476 1680 131410 A RNA synthesis inhibitor. SGTC_3221 9128209 49.47 µM 0.422116817040769 0.340222232205667 no 1151 0.33646987678296 1611 16460723 SGTC_779 1360-0071 233 µM 0.421324295631887 0.34049574689898 no 1152 0.336759145725156 1749 7566 SGTC_2331 7980721 200 µM 0.420933519984601 0.340630642142267 no 1153 0.336901813729949 1693 2981221 SGTC_2010 4012422 159 µM 0.419405504329307 0.341158306725144 no 1154 0.337459901024782 1638 952393 SGTC_2608 thymoquinone 42.66 µM 0.419309909478885 0.34119132851791 no 1155 0.337494827668772 1544 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1018 4259-0013 28.1 µM 0.417620957204179 0.341774951858848 no 1156 0.338112135841736 1622 6801262 SGTC_2704 st078022 71.1 µM 0.414557521612901 0.342834497523026 no 1157 0.339232925001702 1735 54697681 SGTC_1033 k072-0102 21.3 µM 0.414129343423708 0.34298268958999 no 1158 0.339389692006825 1719 5965931 SGTC_1642 st009582 77.7 µM 0.412795556663604 0.34344446666851 no 1159 0.339878203583808 1720 6739311 SGTC_1132 3456-3614 2.5 µM 0.411777494960741 0.343797092342081 no 1160 0.340251259063756 1816 3125502 SGTC_1453 4237-0541 195 µM 0.410092200498794 0.344381125844882 no 1161 0.340869156959324 1739 739892 SGTC_394 menadione 8.33 µM 0.409752672594713 0.344498833150039 no 1162 0.340993693527881 1634 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.408796392790217 0.344830436497494 no 1163 0.34134454366281 1686 688761 SGTC_969 1313-0238 134 µM 0.408005948769789 0.345104624001918 no 1164 0.341634653768496 1612 5212874 SGTC_1686 st019653 115.5 µM 0.406171762177409 0.345741175813604 no 1165 0.342308200291563 1717 97252 SGTC_3344 9148862 3.898 µM 0.405760406295475 0.34588399624535 no 1166 0.342459326599375 1692 4905352 SGTC_2004 4023728 41.89 µM 0.404818278043689 0.346211180442231 no 1167 0.34280554615379 1741 360084 YDR527W RBA50 SGTC_1064 honokiol 6.76 µM 0.403909060101455 0.346527044359389 no 1168 0.343139796842159 1624 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2035 5154463 94.595 µM 0.402350610590316 0.347068700653305 no 1169 0.343713006332649 1693 2769623 SGTC_696 1560-0013 611 µM 0.400829576313342 0.347597654341627 no 1170 0.344272800922266 1683 1650269 SGTC_630 4356-0227 183 µM 0.39857286022226 0.348382994888692 no 1171 0.345103981219139 1636 779312 SGTC_2223 6903751 107.57 µM 0.393383091451809 0.350191505339781 no 1172 0.347018278088447 1693 5598863 SGTC_2175 5807670 165.306 µM 0.392566582549673 0.350476350002599 no 1173 0.347319812651684 1687 241186 SGTC_1831 st055328 12 µM 0.390886507405079 0.351062720018766 no 1174 0.347940563831201 1737 1103068 SGTC_687 k029-0044 34.9 µM 0.389699228424781 0.351477311254161 no 1175 0.348379483562689 1771 5829338 SGTC_2462 5162487 171.77 µM 0.38787430205175 0.352114909929997 no 1176 0.34905452811779 1711 2259986 SGTC_69 0096-0274 206.684 µM 0.38778392725628 0.352146496192581 no 1177 0.349087970404647 1719 6741392 SGTC_3281 9140613 49.47 µM 0.385053540453341 0.353101254628038 no 1178 0.350098874191138 1553 16013766 SGTC_424 splitomicin 100 mM 0.384786634637104 0.353194635692402 no 1179 0.350197751084541 1578 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2450 5739737 12.93 µM 0.383730745642842 0.353564141151068 no 1180 0.35058901112201 1647 2262825 SGTC_2059 5238311 157 µM 0.38129572218046 0.354416796652236 no 1181 0.351491913771538 1617 703021 SGTC_2681 menadione 3.18 µM 0.380283057938538 0.354771609585102 no 1182 0.351867655175193 1664 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2401 5128683 200 µM 0.379971417320765 0.354880826254099 no 1183 0.351983316205728 1568 708373 SGTC_1813 st051246 8.6015 µM 0.379326964986722 0.355106716979946 no 1184 0.352222539059352 1767 5291959 SGTC_389 tpck 16.7 µM 0.379248419532669 0.355134251886276 no 1185 0.35225169939389 1661 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1469 k284-2957 126 µM 0.378946320424069 0.355240162844608 no 1186 0.352363863069433 1694 23884841 SGTC_2350 9023895 38.85 µM 0.376761903056525 0.35600631582263 no 1187 0.353175277432697 1736 2997209 SGTC_614 0462-0418 107 µM 0.376574952576008 0.356071913086621 no 1188 0.353244752343031 1606 5188303 SGTC_1285 0929-0069 65.5 µM 0.371893345026261 0.357715982142395 no 1189 0.354986130121995 1679 1206237 SGTC_1891 st059073 26.2 µM 0.371706537290814 0.357781639610656 no 1190 0.355055678583865 1802 688754 SGTC_411 enrofloxacin 100 µM 0.370085419946495 0.35835159157853 no 1191 0.355659422644871 1821 71188 A bacterial gyrase inhibitor. SGTC_478 N-arachidonylglycine 10 µM 0.369738803430818 0.358473495925987 no 1192 0.355788558243438 1728 5283389 SGTC_1149 3909-7961 23.3 µM 0.3686991826248 0.358839214984906 no 1193 0.356175979032102 1622 735261 SGTC_1350 1495-0454 146 µM 0.368291084635901 0.358982811585414 no 1194 0.356328099756259 1753 1069057 SGTC_1711 st032263 62.8 µM 0.367817763259811 0.359149383165209 no 1195 0.356504561486857 1705 3958979 SGTC_857 0438-0306 1.35 µM 0.366624321594916 0.359569498788724 no 1196 0.356949631826237 1683 4686136 SGTC_273 hydroxyurea 18.1 mM 0.364801304564893 0.360211565299466 no 1197 0.357629865605695 1708 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1996 st072960 66.8 µM 0.364340352369793 0.360373975196837 no 1198 0.357801935344704 1796 1719405 SGTC_2340 7987427 183.45 µM 0.364143361774257 0.360443389695577 no 1199 0.357875479162521 1722 2239331 SGTC_1942 st076330 65.2 µM 0.362846507521819 0.360900483024411 no 1200 0.358359774018306 1719 24208414 SGTC_1275 0867-0008 21.1 µM 0.361720701500056 0.361297449343802 no 1201 0.358780377792993 1707 3422836 SGTC_905 2-aminofluorene 215 µM 0.360983326173787 0.361557533540477 no 1202 0.35905595582684 1660 1539 An established DNA mutagen. YPR165W RHO1 SGTC_109 0132-0036 33.701 µM 0.360298020975666 0.361799309127195 no 1203 0.359312139557717 1717 67274 A color developer. SGTC_121 0557-0495 61.343 µM 0.360006423501618 0.361902201417591 no 1204 0.359421164969407 1703 3104427 SGTC_32 0928-0142 34.1 µM 0.359987028487575 0.361909045443567 no 1205 0.359428416979397 1760 2244242 SGTC_518 1021-0119 62.6 µM 0.359971698686469 0.361914454986597 no 1206 0.359434148997191 1623 1097762 SGTC_1886 st057356 49.9 µM 0.358879720394726 0.362299860552903 no 1207 0.359842535599297 1633 24207747 SGTC_3016 9080866 49.47 µM 0.358834138214797 0.362315951480551 no 1208 0.359859586263651 1638 17066299 SGTC_1884 5633444 25 µM 0.358811507773987 0.362323940324121 no 1209 0.359868051606326 1722 5724239 SGTC_1333 1482-0047 286 µM 0.358384803172682 0.362474583886931 no 1210 0.360027681363362 1788 3811116 SGTC_2749 bexarotene 57.39 µM 0.357578177166258 0.362759412859373 no 1211 0.36032950600547 1615 82146 An retinoic acid receptor inhibitor. SGTC_2845 9003024 42.97 µM 0.357468638014965 0.362798098261602 no 1212 0.360370500263313 1780 2990173 SGTC_2670 beta-carotene 100 µM 0.357149354783567 0.362910865935313 no 1213 0.360489998926575 1724 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_51 1013-0126 23.419 µM 0.356877197039268 0.363006998740308 no 1214 0.360591870615021 1823 1627850 SGTC_2194 5927483 104.545 µM 0.353744631722278 0.364114117929666 no 1215 0.361765135597371 1733 760979 SGTC_3255 9139072 49.47 µM 0.352604864628332 0.364517219418321 no 1216 0.362192345058827 1701 17646060 SGTC_937 3122-0005 46.7 µM 0.352016958669145 0.364725202767577 no 1217 0.362412772145319 1819 759535 SGTC_2288 7946289 167.31 µM 0.351513667789901 0.364903283498259 no 1218 0.362601510243749 1825 1246052 SGTC_2116 5511452 16.8835 µM 0.351000650891474 0.365084835609251 no 1219 0.362793930044265 1722 870744 SGTC_3124 9127567 49.47 µM 0.35046147238671 0.36527567867954 no 1220 0.362996199755536 1808 17592030 SGTC_3175 9106517 49.47 µM 0.348546133714153 0.365953885283977 no 1221 0.363715036747387 1684 41468073 SGTC_1938 st074717 56.4 µM 0.348421550221999 0.365998013873223 no 1222 0.363761810260473 1665 17250979 SGTC_3118 9124250 49.47 µM 0.347647384224827 0.366272270119416 no 1223 0.364052507923057 1695 1504786 SGTC_2816 7982706 58.44 µM 0.347616802405992 0.366283105446104 no 1224 0.364063992937656 1688 2981853 SGTC_1650 st011916 45.8 µM 0.34538192426051 0.367075224585121 no 1225 0.36490363221158 1812 242528 SGTC_855 0428-0020 25 µM 0.344824745262594 0.367272796653569 no 1226 0.36511306436745 1715 6812414 SGTC_2407 paclitaxel 400 µM 0.344532231384388 0.367376534255304 no 1227 0.365223030446493 1797 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_594 1487-1584 10.8 µM 0.344512485937898 0.367383537161698 no 1228 0.365230453841838 1648 5013332 SGTC_801 0866-0028 10.1 µM 0.344197664973196 0.36749519730367 no 1229 0.365348819113455 1718 6849771 SGTC_2791 5663188 71.43 µM 0.343892973015386 0.367603275576329 no 1230 0.365463388331468 1809 54690634 SGTC_2495 cafestol 54.53 µM 0.341471409432783 0.368462608456454 no 1231 0.366374362396424 1762 16667697 An anti-infammatory. SGTC_1061 3448-9325 110 µM 0.341190287640001 0.368562412019469 no 1232 0.36648016721806 1778 723482 SGTC_449 xestospongin c 11.1929 µM 0.341155781969318 0.368574662797479 no 1233 0.366493154695574 1768 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_959 1222-0044 107 µM 0.340597564040733 0.368772869177868 no 1234 0.366703281765241 1871 6083612 SGTC_613 3914-0030 117 µM 0.339764951343833 0.369068569735082 no 1235 0.367016772053626 1728 1145395 SGTC_1666 st014829 29 µM 0.339238214255416 0.369255679283768 no 1236 0.36721514172851 1694 3858230 SGTC_1832 st054113 55 µM 0.33848956429383 0.369521670861874 no 1237 0.367497144983016 1822 1251267 SGTC_3082 9117008 49.47 µM 0.338478619278724 0.369525560034429 no 1238 0.367501268307855 1719 41448529 SGTC_1451 4152-0210 104 µM 0.338307569793103 0.369586342038063 no 1239 0.367565709910396 1829 659563 SGTC_2263 7948595 193.29 µM 0.337039278637086 0.370037127687296 no 1240 0.368043645256264 1694 2971371 SGTC_2374 9071832 200 µM 0.335750064928224 0.370495532845183 no 1241 0.368529674357542 1729 17381698 SGTC_631 k072-0230 41.5 µM 0.334603059404712 0.370903527756906 no 1242 0.368962268376213 1768 5773147 SGTC_1166 k206-0078 225 µM 0.334374627031211 0.370984799507514 no 1243 0.36904844166716 1687 5404595 SGTC_292 k038-0015 474 µM 0.333353023268216 0.37134833643189 no 1244 0.36943390955497 1768 46368540 SGTC_2097 5376186 200 µM 0.331577495227659 0.371980429726033 no 1245 0.370104157640636 1828 742755 SGTC_3258 9138477 49.47 µM 0.330854671503794 0.372237856098809 no 1246 0.370377131157 1758 4970355 SGTC_1015 4130-4525 82 µM 0.33016893053192 0.37248212861279 no 1247 0.370636160769318 1679 1363237 SGTC_2607 solasodine 47.35 µM 0.329764825344771 0.372626101736287 no 1248 0.370788833650151 1692 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2460 5552655 174.22 µM 0.328486375252676 0.373081700413098 no 1249 0.371271972136298 1690 5401989 SGTC_1381 2324-0066 62.1 µM 0.326417442763451 0.373819377610951 no 1250 0.372054271103716 1747 10885928 SGTC_422 cantharidin 155 µM 0.325824920205297 0.374030726636454 no 1251 0.372278411558656 1645 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2814 7977482 42.97 µM 0.324715765401124 0.3744264568555 no 1252 0.372698100822552 1844 6456762 SGTC_2743 auranofin 4.32 µM 0.324034640681422 0.374669537803968 no 1253 0.372955904213727 1795 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1751 st044839 27.194 µM 0.323638838855526 0.374810815121672 no 1254 0.373105740008098 1795 5291326 SGTC_2443 5493264 126.67 µM 0.322282025773985 0.375295242764144 no 1255 0.373619524337155 1847 5340055 SGTC_1200 1643-0193 18.4 µM 0.321381684340205 0.375616803400148 no 1256 0.373960580657962 1849 5403974 SGTC_652 0437-0092 114 µM 0.320978466132047 0.375760842468888 no 1257 0.3741133548581 1708 3091274 SGTC_1959 st077091 55.8 µM 0.319975459499617 0.376119215197409 no 1258 0.374493466911974 1732 821356 YKL052C ASK1 SGTC_81 0411-0046 9.971 µM 0.317571900627732 0.376978437377839 no 1259 0.375404845789091 1736 12925265 SGTC_1510 1123-0200 71.5 µM 0.316647284049308 0.377309131111955 no 1260 0.375755626519913 1856 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2268 7933382 153.85 µM 0.314165236976968 0.378197292034526 no 1261 0.376697771917107 1762 935025 YOR257W CDC31 SGTC_83 0170-0301 39.027 µM 0.313459226451007 0.378450044485208 no 1262 0.376965896715122 1814 3089716 SGTC_2497 7-hydroxyflavone 100 µM 0.313184320790719 0.378548475052327 no 1263 0.377070314935233 1851 5281894 SGTC_1454 4239-0054 42.6 µM 0.312971386651439 0.378624721998145 no 1264 0.377151200510627 1856 1340767 SGTC_2055 5235184 200 µM 0.312515149453014 0.378788106223888 no 1265 0.3773245258026 1764 2836034 SGTC_2466 5983409 37.09 µM 0.312112060114469 0.378932475565337 no 1266 0.377477680696534 1746 2879657 SGTC_1134 3477-0009 42.5 µM 0.311369562200475 0.379198450727066 no 1267 0.377759845226563 1921 3973534 SGTC_131 0141-0277 33.849 µM 0.310374422333721 0.379555016139163 no 1268 0.378138121204131 1856 1547771 SGTC_941 3237-0776 460 µM 0.310227640069741 0.379607617904794 no 1269 0.37819392647876 1868 760008 SGTC_116 0155-0182 31.788 µM 0.310207444538065 0.37961485547011 no 1270 0.378201604834138 1740 771486 SGTC_3049 9092223 49.47 µM 0.30993644188134 0.379711980014768 no 1271 0.378304644887815 1795 8623917 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.309918549559659 0.379718392704637 no 1272 0.378311448172959 1743 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1331 1472-0049 76.2 µM 0.309099932473908 0.380011824163381 no 1273 0.378622755275263 1715 24051409 SGTC_3095 9117207 49.47 µM 0.308855852808338 0.380099327350051 no 1274 0.378715590158463 1896 17015229 SGTC_65 0798-0905 34.986 µM 0.307699025828514 0.38051413620323 no 1275 0.379155680532112 1922 3602145 SGTC_2864 9034755 47.6 µM 0.307343495852096 0.380641647876379 no 1276 0.3792909658977 1912 4930451 SGTC_843 0310-0051 143 µM 0.306441789803577 0.380965105020241 no 1277 0.379634147056459 1792 2065037 SGTC_2073 5212005 126 µM 0.306056267783049 0.381103423664088 no 1278 0.379780902204836 1909 691789 SGTC_1786 berberine 21.6 µM 0.305170013567897 0.381421453951564 no 1279 0.380118334733497 1717 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2620 irigenin 100 µM 0.302774871677679 0.382281345220734 no 1280 0.381030717296737 1858 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_114 0364-0001 490.298 µM 0.300996725318272 0.382920101956854 no 1281 0.38170849581067 1713 4003655 SGTC_1508 1080-0625 72.9 µM 0.296697717866017 0.384465730942436 no 1282 0.383348649754435 1802 767111 SGTC_3301 9125354 19.7965 µM 0.296579030736037 0.384508428907152 no 1283 0.38339396099667 1739 41905162 SGTC_345 1362-0200 395 µM 0.296539536714933 0.384522637281714 no 1284 0.383409039001654 1725 1419823 SGTC_2083 5306046 65.942 µM 0.295433112833553 0.384920747475537 no 1285 0.383831520575189 1761 539837 SGTC_2902 5787006 60.46 µM 0.293176676442718 0.385733027489267 no 1286 0.384693555354506 1749 591003 SGTC_1850 st056238 17 µM 0.292719705630531 0.385897590631511 no 1287 0.384868203204024 1783 5393177 SGTC_1960 st011366 51.8 µM 0.292564114357038 0.385953626444723 no 1288 0.384927673344708 1777 3972846 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.29173707434684 0.386251522778391 no 1289 0.3852438302195 1793 2346 DNA damaging agent; causes G2/M arrest. SGTC_741 4582-0002 126 µM 0.291716689832165 0.386258866042442 no 1290 0.385251623677844 1758 2912688 SGTC_1402 3909-7673 35.9 µM 0.291450353999693 0.386354813906277 no 1291 0.385353454112998 1760 5328014 SGTC_1837 st055472 66.5 µM 0.290301280455411 0.386768848890658 no 1292 0.385792879673187 1847 676091 SGTC_2236 dapsone 200 µM 0.287762445974164 0.387684099945016 no 1293 0.386764292855975 1905 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_963 1269-2853 151 µM 0.286256964730353 0.388227121927939 no 1294 0.387340658342135 1734 3668223 SGTC_2592 piperlongumine 83.33 µM 0.286247135504699 0.388230668015668 no 1295 0.387344422226522 1730 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1490 4089-0339 670 nM 0.285050254769922 0.388662535995903 no 1296 0.387802820265435 1920 742542 SGTC_341 1486-1430 230 µM 0.284791497034717 0.388755921124193 no 1297 0.387901943488155 1752 2054753 YPL210C SRP72 SGTC_1422 4031-0024 15.5 µM 0.284010188197378 0.389037932848966 no 1298 0.388201286476387 1906 782427 SGTC_2703 st077852 53.4 µM 0.283614017281962 0.389180952228813 no 1299 0.388353096899897 1819 6281836 SGTC_1192 1488-0095 21.4 µM 0.282047414557054 0.389746649361758 no 1300 0.388953576968774 1825 915875 SGTC_1704 st028805 70.8 µM 0.281495418282537 0.389946029848822 no 1301 0.389165220877527 1781 2876101 SGTC_199 4063-0024 41.6 µM 0.28051596732261 0.390299877779206 no 1302 0.389540838438233 1896 306215 SGTC_3120 9124077 49.47 µM 0.279363520516591 0.390716340596261 no 1303 0.389982931719847 1920 18774327 YGL155W CDC43 SGTC_1855 st056195 39.6 µM 0.276343880429128 0.391808149658579 no 1304 0.391141977918922 1943 4028379 SGTC_2983 9022671 12.99 µM 0.276162623402852 0.391873713839995 no 1305 0.391211581748923 1978 6405161 SGTC_2003 4023581 200 µM 0.275045104308152 0.392278009929466 no 1306 0.391640792941057 1805 16641307 SGTC_1854 st056233 32.9 µM 0.274738388532727 0.392388993931073 no 1307 0.391758617912784 1963 5393174 SGTC_272 doxorubicin 8.13 µM 0.272586282096932 0.393167971607996 no 1308 0.392585629023958 1860 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_576 1073-0113 22.7 µM 0.272306497374924 0.393269274145351 no 1309 0.392693180373494 1949 5439563 SGTC_2839 9003951 25.97 µM 0.271871502507486 0.393426788460015 no 1310 0.39286041194031 1967 2990634 SGTC_1401 3807-4679 7.6 µM 0.271349071378356 0.393615987036796 no 1311 0.393061284072456 1810 3291456 SGTC_1846 st056244 14.8 µM 0.267885732469567 0.394870869394025 no 1312 0.39439363814621 1878 5393182 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.267785580491366 0.394907174070609 no 1313 0.394432185301758 1798 2724 A muscle relaxant with antifungal properties. SGTC_3340 9146634 11.102 µM 0.267251335308591 0.395100851142147 no 1314 0.394637826577402 1816 4907387 SGTC_1481 3346-2004 36 µM 0.266914881395086 0.395222837299191 no 1315 0.394767349250851 1864 2770522 SGTC_2682 pyrogallin 40.03 µM 0.264662152133671 0.396039860367074 no 1316 0.395634868124226 1890 822798 An ATP competetive kinase inhibitor. SGTC_1277 0873-0036 22 µM 0.264486577692477 0.396103557194732 no 1317 0.395702503069246 1898 5965735 SGTC_724 3910-0327 137 µM 0.262346059735123 0.396880340429208 no 1318 0.396527327312803 1797 2885483 SGTC_1485 3909-9022 254 µM 0.262114370398512 0.396964443933341 no 1319 0.396616634014303 1927 714516 SGTC_1613 st002381 52.1 µM 0.261922614042321 0.397034055342938 no 1320 0.396690552297968 1976 551167 SGTC_1179 1021-1431 9.29 µM 0.261180187049056 0.397303602177168 no 1321 0.396976778214835 1867 2840958 SGTC_3162 9099653 49.47 µM 0.260366300466425 0.397599149614137 no 1322 0.397290617530588 1931 25237511 SGTC_103 0844-0104 51.839 µM 0.258435568079534 0.398300493228388 no 1323 0.398035384654799 1942 5375804 SGTC_2005 4024620 188 µM 0.258346488768552 0.398332859470995 no 1324 0.398069755394497 1842 236743 SGTC_2432 5630864 12.22 µM 0.258115080331352 0.398416943111237 no 1325 0.398159046704549 1828 5714970 SGTC_1614 st002383 48.6 µM 0.257092818398811 0.398788444488449 no 1326 0.39855356067818 1937 1947235 SGTC_933 2914-0560 114 µM 0.256280873636028 0.399083579634143 no 1327 0.398866982414626 2005 463887 SGTC_439 amiodarone 34.4 µM 0.255031163838346 0.399537951412004 no 1328 0.399349514804358 1914 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1121 fusaric acid 630.51 nM 0.253976573103475 0.399921487355784 no 1329 0.399756828384326 1803 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2324 6149169 200 µM 0.25349547970941 0.400096484585971 no 1330 0.399942676896267 1945 2888231 SGTC_876 0720-0963 56.8 µM 0.25314707665845 0.400223228367313 no 1331 0.400077280693637 1998 765861 SGTC_3269 9137823 49.47 µM 0.252445381993494 0.400478526200357 no 1332 0.400348412979099 1820 17682936 SGTC_1484 3473-2379 286 µM 0.250557987489712 0.401165428381319 no 1333 0.401077933404367 1975 671917 SGTC_2447 5741742 33.78 µM 0.249987874136934 0.401372976786614 no 1334 0.401298363008819 1907 1776504 SGTC_2886 9058944 51.95 µM 0.249766516553923 0.401453568990056 no 1335 0.401383957555585 1875 4949929 SGTC_3128 9127691 49.47 µM 0.249731312525153 0.40146638651253 no 1336 0.401397570685151 1870 41316314 SGTC_1558 st069300 45.6 µM 0.249009877224836 0.401729079016658 no 1337 0.401676570550725 1986 24208000 SGTC_2980 9014342 25.29 µM 0.246939347782755 0.402483256433432 no 1338 0.402477581981506 1875 2996599 SGTC_475 α-linolenic acid 10 µM 0.246681797541641 0.402577092948255 no 1339 0.402577247378655 1962 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1030 k029-0042 36.7 µM 0.245501114522295 0.403007337794661 no 1340 0.403034222655133 1877 6080581 SGTC_203 k066-0004 30.888 µM 0.244255744813421 0.403461281973007 no 1341 0.403516378023502 2018 6795412 SGTC_360 0957-0399 1.01 µM 0.242580129812038 0.404072258132637 no 1342 0.404165337809988 1958 6752301 YPR165W RHO1 SGTC_2778 tioconazole 65.09 nM 0.241627410317631 0.404419750826019 no 1343 0.404534440476447 1856 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1756 st041558 35.5 µM 0.241574963183329 0.404438882464347 no 1344 0.404554762020294 2035 3955792 SGTC_2870 9038528 12.99 µM 0.241152120860965 0.404593135010127 no 1345 0.404718608948809 1888 6463316 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.2399625144183 0.405027181976685 no 1346 0.405179658401856 1957 5282309 SGTC_1737 st035557 69.7 µM 0.237408216857392 0.40595955255177 no 1347 0.406170057900928 1801 5716916 SGTC_167 3672-0051 66.205 µM 0.237131424775446 0.406060619433984 no 1348 0.406277417033922 1860 3237971 SGTC_535 2293-4129 48.2 µM 0.236505512060353 0.406289186065195 no 1349 0.406520215292404 2000 396118 YIL048W NEO1 SGTC_1250 0485-0349 40.2 µM 0.235604225832775 0.406618367847099 no 1350 0.406869897012319 1860 6842794 YDL195W SEC31 SGTC_3125 9127534 49.47 µM 0.235079441883555 0.406810068024739 no 1351 0.407073537315771 2017 1639235 SGTC_2396 5342950 42.78 µM 0.23487762939159 0.406883794768617 no 1352 0.407151856534107 1871 1886677 SGTC_1498 4478-3555 97.6 µM 0.234020005525355 0.407197141267683 no 1353 0.40748472384103 2016 3437919 SGTC_3069 9117009 49.47 µM 0.233446644714145 0.407406660889777 no 1354 0.407707298151776 2012 41904981 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.232910200906287 0.407602714154788 no 1355 0.40791556854132 1994 688662 SGTC_977 1348-1378 135 µM 0.232669035612399 0.407690859995032 no 1356 0.408009207687687 1928 X977 SGTC_3137 9097352 49.47 µM 0.231182205178958 0.408234399115087 no 1357 0.408586626899845 1967 44120435 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.231132336772221 0.408252632525775 no 1358 0.408605997031911 1880 688803 SGTC_2395 5646831 180.19 µM 0.230019115469311 0.408659711834804 no 1359 0.409038457968072 1936 6808628 SGTC_2707 st078556 66.6 µM 0.229593162876046 0.408815498952727 no 1360 0.409203960101493 2039 17250899 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.22881124149764 0.409101514920968 no 1361 0.409507814554661 2013 1241132 A phosphatase inhibitor. SGTC_1839 st053978 48 µM 0.228694497361623 0.40914422245916 no 1362 0.409553185965844 2023 3788398 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.228539680622431 0.409200859445089 no 1363 0.40961335577207 1980 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2537 larixol 68.93 µM 0.22759012051267 0.409548280763968 no 1364 0.409982450551818 1915 6708759 SGTC_684 1140-0066 328 µM 0.226826789701705 0.409827616762492 no 1365 0.410279215708031 1888 6813534 SGTC_1342 1486-1464 234 µM 0.225975126051157 0.410139331614488 no 1366 0.410610383249133 1876 3253938 SGTC_593 1203-0218 61.7 µM 0.225844813835543 0.410187031810941 no 1367 0.410661060496426 2020 3666956 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.225790188232659 0.410207027660846 no 1368 0.410682304345219 1876 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1105 epirubicin 18.1 µM 0.22557645906051 0.410285266046496 no 1369 0.410765425949429 1858 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_530 4358-1714 28 µM 0.225331626539889 0.410374894611656 no 1370 0.410860648909431 1954 1564641 SGTC_2957 9076800 11.52 µM 0.22513218095264 0.410447911337379 no 1371 0.410938223366653 1850 16459615 SGTC_2862 9027634 71.43 µM 0.225048498588414 0.410478548248059 no 1372 0.41097077270005 1805 5012562 SGTC_974 1326-0144 138 µM 0.224299524195865 0.410752779211609 no 1373 0.411262123206823 1865 5411856 SGTC_805 3852-0218 479 µM 0.224159979838345 0.410803877084072 no 1374 0.411316411277013 1851 6615355 SGTC_763 3453-1109 128 µM 0.224078690883001 0.4108336438917 no 1375 0.411348036559676 2015 1560353 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.223871272955736 0.410909599581197 no 1376 0.411428734640954 1850 2374 Ca(2+)-ATPase inhibitor. SGTC_1818 st052136 56.3 µM 0.22206820787039 0.411570015889158 no 1377 0.412130393202691 1921 674169 SGTC_1054 3429-0080 167 µM 0.221817659601244 0.411661805142087 no 1378 0.412227915761589 1987 1162877 SGTC_2034 5197015 53.07 µM 0.21951007658698 0.412507423105954 no 1379 0.413126365644421 2018 780676 SGTC_802 4112-3352 742 µM 0.217117523722601 0.413384607395826 no 1380 0.414058378866102 2006 704594 SGTC_738 1315-0003 72.4 µM 0.216841172299538 0.413485954368319 no 1381 0.414166062194208 2016 6251474 SGTC_3096 9117468 49.47 µM 0.216458341458194 0.413626360296953 no 1382 0.414315247042037 2013 41316311 SGTC_3064 1327-0027 10 µM 0.216289905177708 0.413688138998139 no 1383 0.414380888672538 1935 16000455 YPR107C YTH1 SGTC_2258 7960471 200 µM 0.215933522365474 0.413818859369686 no 1384 0.414519783192202 1876 2974708 SGTC_3015 9080845 49.47 µM 0.215502266225107 0.41397705587035 no 1385 0.414687872689778 2023 5296973 SGTC_1685 st024049 53.0905 µM 0.214832668538918 0.414222710199064 no 1386 0.414948890852304 1968 1941139 SGTC_2856 9022925 19.48 µM 0.211864518009142 0.415312034097723 no 1387 0.416106366359769 1945 4944862 SGTC_63 0099-0242 26.702 µM 0.211584197092453 0.415414946858344 no 1388 0.416215719552032 2046 3898502 YLR359W ADE13 SGTC_425 3825-7017 13.1 µM 0.21016873017297 0.415934688355746 no 1389 0.416767992104918 1973 3397440 SGTC_2467 5474540 200 µM 0.209704152405996 0.416105307519227 no 1390 0.416949292222911 1985 5413519 SGTC_3226 9131256 49.47 µM 0.205320826112282 0.417715886293874 no 1391 0.418660736889427 1974 17178073 SGTC_57 miconazole 162.5 nM 0.204927222282718 0.417860577314695 no 1392 0.418814493118886 1891 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1461 k072-0203 53.8 µM 0.202936313574939 0.418592616727322 no 1393 0.419592405328027 2050 5418714 SGTC_1825 st052143 62.6 µM 0.202574608889715 0.418725642667029 no 1394 0.419733768839063 2030 674173 SGTC_151 3013-0144 2.285 µM 0.202229876973174 0.418852435097271 no 1395 0.419868508595724 2052 906558 YHR107C CDC12 SGTC_1051 3253-3903 78 µM 0.201595420421743 0.419085810298765 no 1396 0.420116512849862 1985 5509239 SGTC_1640 st009078 66.4 µM 0.199416875195879 0.419887371302268 no 1397 0.42096833053962 2036 690618 SGTC_3059 1327-0034 3 µM 0.198387026675968 0.42026640358735 no 1398 0.421371133469124 1923 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_582 0987-0078 156 µM 0.197561588940516 0.420570256580664 no 1399 0.421694044991218 2050 1625765 SGTC_1004 4084-0029 199 µM 0.195780513001104 0.421226051864466 no 1400 0.422390981635991 2071 716894 YLR208W SEC13 SGTC_2674 ligustilide 100 µM 0.195251720304209 0.421420796429974 no 1401 0.422597945593002 1983 5319022 A signalling regulator. SGTC_52 0329-0193 875 nM 0.194716320206762 0.421617993964027 no 1402 0.422807517389421 2032 3739292 SGTC_2320 7373003 200 µM 0.193363280124526 0.422116430591585 no 1403 0.423337235460581 1897 5415828 SGTC_1620 st003704 16.5 µM 0.193241700248292 0.422161224642031 no 1404 0.423384841041673 2068 2834414 SGTC_3236 9132701 49.47 µM 0.192837462950689 0.422310166278114 no 1405 0.423543131453598 1937 24282524 SGTC_2843 9000894 45.46 µM 0.191884404648129 0.422661365500316 no 1406 0.423916376866088 2015 2242070 SGTC_1563 conessine 56.1 µM 0.1918683596336 0.422667278568705 no 1407 0.423922661146697 2069 441082 An anti-amoebic, histamine inhibitor. SGTC_331 k048-0133 24.5 µM 0.189827206384677 0.423419646335595 no 1408 0.424722267946493 1945 6813582 SGTC_2560 caryophyllene 100 µM 0.189346306490816 0.423596946482151 no 1409 0.424910702173183 2051 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2572 astragaloside iv 100 µM 0.187992899031367 0.424096009218609 no 1410 0.425441108845782 1949 45006101 An anti-inflammatory agent. SGTC_1120 ficusin 1.78878 µM 0.187523329507041 0.424269189295419 no 1411 0.425625166909684 2023 6199 A DNA cross-linker. SGTC_22 0964-0034 14.468 µM 0.185259887975273 0.425104164746571 no 1412 0.426512599071013 1981 138402 SGTC_1664 st014217 9.02 µM 0.185116865946481 0.425156936387636 no 1413 0.426568686559407 2118 3982782 SGTC_789 1309-1135 70.6 µM 0.184223881591461 0.425486456129241 no 1414 0.426918912651164 2076 3092424 SGTC_670 4204-0025 119 µM 0.18416766108457 0.425507203776491 no 1415 0.42694096411545 2040 719039 SGTC_3316 9136639 10.545 µM 0.183592212290181 0.425719579571905 no 1416 0.427166686483974 2028 4903665 SGTC_993 3909-8757 62.7 µM 0.183206625733801 0.425861896652599 no 1417 0.427317947886903 1977 4288324 YLR208W SEC13 SGTC_3295 9122362 53.5725 µM 0.181512667435057 0.42648723801406 no 1418 0.427982595562239 1931 4730473 SGTC_1880 MG-132 525 µM 0.18106766749951 0.426651544838139 no 1419 0.428157231339756 2074 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1723 st034307 2.5525 µM 0.17963056443571 0.427182251573564 no 1420 0.428721304007511 1963 867466 SGTC_3307 9126885 69.2785 µM 0.179108355432704 0.427375130455471 no 1421 0.428926310705325 1917 24824909 SGTC_1264 0783-0040 158 µM 0.178362849482083 0.427650514558993 no 1422 0.429219011629999 1939 2855798 SGTC_2024 5144227 134 µM 0.177275961092523 0.42805206580626 no 1423 0.429645815997725 2045 3475211 SGTC_1681 tripelennamine 100 µM 0.177223403708108 0.42807148504012 no 1424 0.42966645656348 2116 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1958 st076513 41.9 µM 0.176191600065445 0.428452757579828 no 1425 0.430071709867008 1978 732122 YGL099W LSG1 SGTC_2611 pyromycin 23.93 µM 0.175588720718746 0.428675564760696 no 1426 0.430308532118531 1949 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_739 1486-1183 203 µM 0.174746533301523 0.428986851491481 no 1427 0.430639400998748 2114 4346692 SGTC_16 erodoxin 22.806 µM 0.174224518043362 0.42917981935862 no 1428 0.430844508794547 2054 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_700 3453-2283 142 µM 0.170399539298342 0.430594272343961 no 1429 0.432347967215287 2070 565664 SGTC_1315 1237-0019 3.69 µM 0.168187265915746 0.431412764902879 no 1430 0.433217979286339 2107 825140 SGTC_722 3534-0461 190 µM 0.167793243004762 0.431558575733308 no 1431 0.433372969217573 1968 658262 SGTC_224 benfluorex 43.875 µM 0.167772382891609 0.431566295418707 no 1432 0.433381174882861 2104 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1442 4112-3290 3 µM 0.16748546637441 0.431672477035639 no 1433 0.433494041080777 2101 704353 SGTC_3131 9127911 49.47 µM 0.167400997546966 0.43170373806851 no 1434 0.433527270161198 2035 45595681 SGTC_919 tnp00227 403.569 nM 0.166961146124957 0.431866529404671 no 1435 0.433700310319454 1993 1269246 A methoxyflavone. YNL221C POP1 SGTC_605 1315-0399 119 µM 0.166452850174081 0.432054666832452 no 1436 0.433900292787537 2054 24020461 SGTC_2306 7482397 179.52 µM 0.165375746151988 0.432453390132964 no 1437 0.434324121290877 2096 891448 SGTC_3195 9113082 49.47 µM 0.164675180506864 0.432712763081646 no 1438 0.434599826667161 2161 17018038 SGTC_215 1287-0124 461.5 µM 0.163989483668983 0.432966659177252 no 1439 0.434869711275955 2136 5560863 SGTC_2193 5925765 200 µM 0.163346331612734 0.433204827176503 no 1440 0.435122878195872 2085 877370 SGTC_3354 9151612 71.43 µM 0.163113682173816 0.433290986424357 no 1441 0.435214463627312 2105 27261949 SGTC_3070 9117005 49.47 µM 0.162744422480407 0.433427744336894 no 1442 0.435359834569234 2134 8779016 SGTC_1776 st049249 45.9 µM 0.162633082203441 0.433468981552819 no 1443 0.435403668961532 1958 1822314 SGTC_606 k015-0008 38.6 µM 0.161952300656922 0.433721139070184 no 1444 0.435671708221033 2102 1970475 SGTC_1790 st045711 43.5 µM 0.161723951823455 0.433805724194407 no 1445 0.435761621002551 2134 585119 SGTC_2283 7944793 200 µM 0.160515722931004 0.43425332749441 no 1446 0.43623741855206 1992 2970533 SGTC_2880 9042983 58.44 µM 0.160422194031798 0.434287979951898 no 1447 0.436274253858306 2014 6464714 SGTC_1432 4049-0298 68.4 µM 0.159581753254755 0.434599385885348 no 1448 0.43660527677613 2158 741646 SGTC_2764 methyldopa 94.69 µM 0.159003067889698 0.434813827993993 no 1449 0.436833228378492 2104 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1812 st052057 4.327 µM 0.158050004239749 0.435167044376842 no 1450 0.437208698083561 2064 3645418 SGTC_1382 3002-2117 298 µM 0.157974552443481 0.435195009896789 no 1451 0.437238425553106 2127 1497314 SGTC_740 k014-0057 261 µM 0.157786392169553 0.43526475119756 no 1452 0.437312560902182 2115 4012779 SGTC_3072 9116419 49.47 µM 0.155739359749955 0.436023610118106 no 1453 0.438119235546432 2012 17170162 SGTC_47 0149-0135 24.25 µM 0.154615205966406 0.436440447497347 no 1454 0.438562340766998 2076 5239155 SGTC_1299 1079-1439 3.74 µM 0.153898071271174 0.436706398690936 no 1455 0.4388450524451 2011 323161 SGTC_2634 4'-methoxyflavone 100 µM 0.153618001945038 0.436810270875662 no 1456 0.438955470963903 1996 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_3181 9108277 49.47 µM 0.152658760632166 0.437166067515915 no 1457 0.439333691865377 2038 17097298 SGTC_1052 3253-3998 198 µM 0.150408236510571 0.438001018851145 no 1458 0.440221271699295 2120 5450317 SGTC_450 aminopyrene 156 nM 0.149623660843107 0.438292163917555 no 1459 0.44053076983543 2126 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_504 lovastatin 124 µM 0.147622903535902 0.439034767828856 no 1460 0.441320189366949 1971 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1962 st076595 64.5 µM 0.145385563945894 0.43986543604781 no 1461 0.442203230933217 2072 279619 SGTC_2513 baicalein 25.65 µM 0.143457040564986 0.440581661167472 no 1462 0.442964618458768 2011 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2378 9074213 121.43 µM 0.141159544185289 0.441435171021136 no 1463 0.443871952527224 2162 657714 SGTC_1972 st070201 17.4 µM 0.140650131558267 0.441624452568678 no 1464 0.444073171296351 2176 2829099 SGTC_1507 4075-3230 155 µM 0.14050271417966 0.441679230672143 no 1465 0.444131404079143 2171 659771 SGTC_2919 7978188 46.38 µM 0.140099048087346 0.441829232689197 no 1466 0.44429086634612 2168 2980291 SGTC_2908 7930301 100 µM 0.138952428053459 0.442255361267402 no 1467 0.444743870588284 2144 2223178 SGTC_2128 5255449 168.493 µM 0.137530773863229 0.442783795968478 no 1468 0.44530563491214 2108 736008 SGTC_2701 st077767 14.721 µM 0.136635996613311 0.443116440606452 no 1469 0.445659261072637 2059 5721188 SGTC_561 1550-0330 72.9 µM 0.134756258326375 0.443815387153016 no 1470 0.446402295545007 2036 6812934 SGTC_1274 0865-0114 173 µM 0.134313668341951 0.443979981706698 no 1471 0.446577272701138 2079 870624 SGTC_2241 6772625 37.8075 µM 0.13132219280951 0.445092731926874 no 1472 0.447760218247661 2212 2285411 SGTC_1793 st048256 72.231 µM 0.13000621319489 0.445582379320325 no 1473 0.448280755497116 2193 672022 SGTC_2499 avocadenofuran 51.48 µM 0.128655234551619 0.446085135444899 no 1474 0.448815229292951 2153 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_913 3487-1245 167 µM 0.127941658627917 0.446350722178031 no 1475 0.449097571558248 2074 4016153 SGTC_3090 9117696 49.47 µM 0.12619863525744 0.446999561233338 no 1476 0.449787345818322 2168 7923821 SGTC_330 1488-0319 80.1 µM 0.126135358234834 0.447023118733869 no 1477 0.449812389578012 2079 6846614 SGTC_409 arachidonic acid 100 µM 0.125293310103207 0.447336623896309 no 1478 0.450145674107105 2168 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_994 3910-0338 138 µM 0.124613481397162 0.447589756734202 no 1479 0.450414777491896 2139 3479481 SGTC_2857 9024691 58.44 µM 0.124566185934547 0.447607367899064 no 1480 0.450433499776726 2081 16478292 SGTC_2257 7960413 200 µM 0.124142159433048 0.447765265047042 no 1481 0.4506013589605 2110 2974689 YIL048W NEO1 SGTC_839 0122-0028 230 µM 0.123633442749124 0.447954709677882 no 1482 0.45080275606655 2112 759448 SGTC_1380 2291-0730 164 µM 0.123278030710069 0.448087071146449 no 1483 0.450943468537039 2060 2999191 SGTC_1521 st012942 49.4 µM 0.123242185028278 0.448100421007147 no 1484 0.450957660673592 2198 24207259 SGTC_363 0455-0021 3.06 µM 0.12288197062991 0.448234577443325 no 1485 0.451100281383637 2133 4597466 SGTC_516 3992-2719 87.3 µM 0.12219089717443 0.448491973922353 no 1486 0.451373917718462 2150 5350887 YDR037W KRS1 SGTC_2127 5253358 187.912 µM 0.122121463955624 0.44851783614522 no 1487 0.451401411663789 2095 20612 SGTC_3103 9120822 49.47 µM 0.121985193397167 0.448568594323658 no 1488 0.451455372324106 2178 17141819 SGTC_314 1671-0008 2.74 µM 0.121886513276688 0.448605351308054 no 1489 0.451494448415349 2123 3913060 SGTC_2899 9053889 58.44 µM 0.121812423353045 0.448632949073134 no 1490 0.451523787405696 2221 6470052 SGTC_2023 5144124 124 µM 0.117116423597921 0.450382664177545 no 1491 0.453383897575783 2112 2830192 SGTC_1361 1608-0041 5.61 µM 0.115937746235889 0.45082198855674 no 1492 0.453850940112284 2124 X1361 SGTC_458 nppb 133 µM 0.114282799672818 0.451438932701129 no 1493 0.454506808516725 2205 4549 A chloride channel blocker. SGTC_2242 6630449 61.2675 µM 0.113002250275416 0.451916386675044 no 1494 0.455014385590634 2125 691249 YDR170C SEC7 SGTC_1462 k081-0014 26.5 µM 0.11265243157629 0.452046829010626 no 1495 0.455153057596558 2165 3270634 SGTC_3148 9097893 49.47 µM 0.111532517693358 0.452464463452734 no 1496 0.455597040530601 2097 17174100 SGTC_2945 9067681 61.76 µM 0.11070390260784 0.452773501628456 no 1497 0.455925575585987 2209 16456930 SGTC_751 0833-0568 350 µM 0.109607138403985 0.453182591981487 no 1498 0.456360474572302 2126 6954252 SGTC_2733 amorolfine 100 µM 0.109594043352268 0.45318747670465 no 1499 0.456365667459015 2228 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_616 4092-0450 108 µM 0.109338103791444 0.453282948837064 no 1500 0.456467162646107 2133 787165 SGTC_2014 4013930 200 µM 0.10769967964431 0.45389418752176 no 1501 0.45711696182156 2239 64556 SGTC_2644 guaiazulene 100 µM 0.105890068782286 0.454569416856369 no 1502 0.457834786864891 2201 3515 A coloring agent. SGTC_672 1441-0018 53.7 µM 0.105793399477883 0.4546054912789 no 1503 0.457873136927138 2142 251141 SGTC_3032 9089427 49.47 µM 0.105659615564882 0.45465541650734 no 1504 0.457926211519527 2128 17173707 SGTC_1617 st002906 78 µM 0.105642229713126 0.454661904579332 no 1505 0.457933108868742 2185 5150859 SGTC_1781 st038725 66.3 µM 0.10563360761138 0.454665122189585 no 1506 0.45793652945056 2031 4270275 YIL048W NEO1 SGTC_3019 9081971 49.47 µM 0.105120514713197 0.454856604397902 no 1507 0.458140090551531 2205 16451803 SGTC_1588 farnesol 29.9 µM 0.104764719316912 0.454989390585346 no 1508 0.458281252926206 2174 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2587 piperic acid 92.2 µM 0.104217814922782 0.455193510249774 no 1509 0.458498248346124 2127 5370536 SGTC_2773 thioridazine 9.09 µM 0.103956400845789 0.455291081308611 no 1510 0.458601974060459 2242 5452 An antipsychotic. SGTC_2937 9044753 11.33 µM 0.101667234261295 0.456145612021871 no 1511 0.459510405309064 2210 6465530 YGL099W LSG1 SGTC_1257 0669-0121 16 µM 0.100811240021441 0.456465201326859 no 1512 0.45985015202674 2203 4307855 SGTC_705 1124-0212 310 µM 0.0968841174975737 0.45793176806996 no 1513 0.461409210933246 2241 9554485 SGTC_663 1486-0733 13.9 µM 0.0966919811359178 0.458003535418212 no 1514 0.461485504058974 2145 722445 YPR165W RHO1 SGTC_423 5-fluorouracil 457 µM 0.0956122811438283 0.458406853586746 no 1515 0.461914255474047 2152 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_177 1327-0068 8.361 µM 0.0950937460998067 0.4586005657928 no 1516 0.462120182727901 2247 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2177 5811945 192 µM 0.0942932846248032 0.45889961821192 no 1517 0.462438092120906 2188 5343475 SGTC_2077 5212015 200 µM 0.0930633615008015 0.459359162780717 no 1518 0.462926612181243 2259 780900 SGTC_1695 st026914 34.495 µM 0.0921184619762144 0.459712248957485 no 1519 0.463301960141627 2168 3289191 SGTC_2160 5660466 132.927 µM 0.0918332492009735 0.45981883235306 no 1520 0.463415263313833 2253 2859134 SGTC_2832 7992762 51.95 µM 0.0901697817505627 0.460440523821874 no 1521 0.464076148576195 2054 2985177 SGTC_1707 st032323 6.317 µM 0.0898467814617391 0.460561250713737 no 1522 0.464204486130339 2172 3132057 YMR211W DML1 SGTC_668 1682-0499 62.6 µM 0.0895496598714985 0.460672308209132 no 1523 0.464322544602383 2140 682214 SGTC_2391 6285546 200 µM 0.0894307737304299 0.460716746085599 no 1524 0.464369783773931 2220 846083 SGTC_2953 9074162 66.49 µM 0.0889656610146029 0.460890603030109 no 1525 0.464554600205876 2257 16451992 SGTC_3193 9111931 49.47 µM 0.0885864202412375 0.461032366980949 no 1526 0.464705300364385 2191 17087244 SGTC_2808 7946468 45.46 µM 0.0879573837867684 0.461267517937942 no 1527 0.464955273810667 2193 2970879 SGTC_1684 st024538 14.6195 µM 0.0878596579472156 0.461304051735596 no 1528 0.464994110426746 2163 6732859 SGTC_371 0195-0006 7.36 µM 0.0873517968950207 0.461493915605759 no 1529 0.465195941679376 2190 3928593 SGTC_1386 3228-0095 33.8 µM 0.0865811560411627 0.461782036461823 no 1530 0.465502222472156 2226 870181 SGTC_2015 5119600 184 µM 0.0863475593733919 0.461869375628663 no 1531 0.465595066355431 2220 2828786 SGTC_235 0330-0087 5 mM 0.0851358051688453 0.462322466312734 no 1532 0.466076712609824 2231 46494818 YHR062C RPP1 SGTC_2885 9057732 51.95 µM 0.0835803261280205 0.462904151777355 no 1533 0.466695054835297 2185 6471414 SGTC_2487 5918373 44.05 µM 0.0815466096888429 0.463664797922606 no 1534 0.467503629552202 2291 2876279 SGTC_1529 apigenin 74 µM 0.0814047883409495 0.463717846618029 no 1535 0.467560020603065 2254 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2226 7298446 200 µM 0.0806532505823244 0.463998972288098 no 1536 0.467858858132143 2269 3283010 SGTC_133 0724-0033 378.92 µM 0.0800215996589466 0.46423526612714 no 1537 0.468110038506621 2276 280309 SGTC_3284 9108171 64.8615 µM 0.0788042260733279 0.464690708048706 no 1538 0.468594171291746 2181 8687505 SGTC_2074 5212007 75.395 µM 0.0784108645484566 0.464837881772047 no 1539 0.4687506157405 2273 758611 SGTC_3146 9095609 49.47 µM 0.0781758235937259 0.464925823153905 no 1540 0.468844096563631 2213 17173999 SGTC_3130 9127414 49.47 µM 0.0760148117946756 0.465734452892741 no 1541 0.469703657092636 2290 1494646 SGTC_1505 k297-0037 20.6 µM 0.0752257245745557 0.466029757150072 no 1542 0.470017558544287 2154 4089396 SGTC_1155 4088-0394 48.2 µM 0.0734297551032236 0.466701941720232 no 1543 0.470732070176363 2220 2326248 SGTC_503 tyrphostin 8 294 µM 0.072003205024345 0.467235930020412 no 1544 0.471299678616685 2281 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_748 act1.228 77.9 µM 0.0715021970277632 0.467423482103886 no 1545 0.471499038030157 2227 4421505 YNR035C ARC35 SGTC_1243 0416-0003 5.65 µM 0.0712552866455252 0.46751591554034 no 1546 0.471597290407538 2197 2141977 SGTC_172 1112-0046 2.638 µM 0.0712360444692919 0.467523119120196 no 1547 0.471604947467116 2204 2802135 YIL048W NEO1 SGTC_2967 9089538 49.85 µM 0.0700117785797488 0.467981462074482 no 1548 0.47209214234634 2287 728216 SGTC_961 1252-1571 372 µM 0.0698865209254268 0.468028358673398 no 1549 0.472141990819877 2278 6813498 SGTC_1367 1812-0510 76.9 µM 0.0696018079015652 0.468134957181636 no 1550 0.472255298967609 2243 1142582 YDR527W RBA50 SGTC_1973 st070275 50.2 µM 0.0695311584522059 0.468161409174 no 1551 0.472283415901769 2279 17118334 SGTC_2157 5649910 96.377 µM 0.0692321989160627 0.46827334472723 no 1552 0.472402396779401 2245 2858091 SGTC_2064 5220758 200 µM 0.0686381099901009 0.468495789197782 no 1553 0.472638841499643 2205 788518 SGTC_2018 5133068 143 µM 0.0665092569257439 0.469292975053956 no 1554 0.473486194034305 2287 785362 SGTC_321 4534-3890 65.3 µM 0.0657564932185734 0.469574890074358 no 1555 0.47378584730484 2295 699746 SGTC_3325 9138760 55.175 µM 0.0648064233435293 0.469930719324841 no 1556 0.474164063557688 2256 43844959 SGTC_2434 5670830 169.91 µM 0.0643308588465744 0.470108841322057 no 1557 0.474353391265202 2221 1549830 SGTC_1742 st038235 28.8875 µM 0.0642306757795796 0.470146365509407 no 1558 0.474393276038926 2214 564103 YBR002C RER2 SGTC_2789 5281112 71.43 µM 0.0633949953278297 0.470459385088491 no 1559 0.47472598619344 2238 765948 SGTC_1195 1502-0147 41.1 µM 0.0629668381275476 0.470619766375866 no 1560 0.474896455619883 2281 817940 SGTC_2301 7769476 200 µM 0.0629467144671908 0.470627304515701 no 1561 0.474904467904523 2231 977820 SGTC_2113 5491891 107.031 µM 0.0627214933841706 0.470711670998992 no 1562 0.474994140921826 2241 789979 SGTC_2838 9002687 71.43 µM 0.0624662598471232 0.470807281558548 no 1563 0.47509576509431 2239 6457060 SGTC_347 4534-1311 26.2 µM 0.0621349956065611 0.470931375750994 no 1564 0.475227664182246 2298 2862016 SGTC_375 3970-0961 9.27 µM 0.0618575729840407 0.471035302621714 no 1565 0.475338127306765 2238 2898222 SGTC_2881 9058953 51.95 µM 0.0611990531065389 0.471282002394051 no 1566 0.475600341916319 2284 17122249 SGTC_25 0118-0223 35.662 µM 0.0603580185759028 0.471597093219484 no 1567 0.475935246993634 2281 5333628 SGTC_485 niflumic acid 177 µM 0.0603517002227209 0.471599460437289 no 1568 0.475937763065026 2279 4488 A COX2 inhibitor. SGTC_3140 9094243 49.47 µM 0.0601059812776924 0.471691521636949 no 1569 0.476035613103845 2325 19291112 SGTC_2318 6029776 164 µM 0.0589780374810687 0.472114137033695 no 1570 0.476484800603141 2271 818325 SGTC_1671 st016596 74.5 µM 0.0588239336174399 0.472171878764653 no 1571 0.476546172597734 2286 2829167 SGTC_1618 st003135 44.5 µM 0.0588013692267883 0.472180333546465 no 1572 0.476555158932208 2298 1270615 SGTC_680 0417-1641 114 µM 0.0580449960101344 0.472463750623104 no 1573 0.476856393644546 2261 2835990 SGTC_2809 7964133 12.99 µM 0.0574385013097531 0.472691017499546 no 1574 0.477097947001162 2247 1253665 SGTC_3028 9087778 49.47 µM 0.0569924804655895 0.472858156977171 no 1575 0.477275592562915 2289 17217395 SGTC_2476 5806916 10.51 µM 0.0567093282947145 0.472964266396677 no 1576 0.477388371535699 2266 2870194 SGTC_2795 7780010 54.55 µM 0.0560314052486357 0.473218321394427 no 1577 0.477658394340788 2254 953673 SGTC_2220 6782180 200 µM 0.0552874155425111 0.473497147732864 no 1578 0.477954743887216 2303 833803 SGTC_3213 9129884 49.47 µM 0.0550751717425466 0.473576693103766 no 1579 0.478039288097071 2249 17190742 SGTC_2586 curcumin 80 µM 0.0549454346909255 0.473625316865958 no 1580 0.478090967438782 2282 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_702 1488-0190 94 µM 0.0547085708294841 0.473714091378424 no 1581 0.47818532052826 2306 949357 SGTC_1214 0358-0031 63.7 µM 0.0542535387408137 0.473884637101367 no 1582 0.478366582856001 2289 4301366 SGTC_897 1000-0139 31.4 µM 0.053000773429553 0.474354197338135 no 1583 0.478865645736851 2305 6151020 SGTC_1398 3558-0053 112 µM 0.0522780966650933 0.474625086564482 no 1584 0.479153552888137 2260 4532369 SGTC_2529 gangaleoidin 93.61 µM 0.0516785868916849 0.474849816602153 no 1585 0.479392399810563 2293 4565183 SGTC_2891 9063876 19.48 µM 0.0506505232860176 0.475235211347301 no 1586 0.479802001350915 2337 6472478 SGTC_765 1319-0117 244 µM 0.0481499243344012 0.476172717933586 no 1587 0.480798379226351 2328 3487746 YGL099W LSG1 SGTC_1265 0819-1001 68.8 µM 0.048122506204033 0.476182998082558 no 1588 0.480809304812657 2326 3106768 SGTC_3282 9108498 15.4605 µM 0.0475507957326792 0.476397358707242 no 1589 0.481037123475681 2262 16459645 SGTC_1174 0739-0097 51.1 µM 0.0454037599492918 0.477202441936043 no 1590 0.481892742036997 2272 728447 SGTC_2883 9059145 45.46 µM 0.0436203940218581 0.477871229206041 no 1591 0.482603497545069 2315 16476510 SGTC_1181 1222-0449 220 µM 0.042842798658251 0.478162858010808 no 1592 0.482913423448239 2303 658318 SGTC_356 1634-0012 32.5 µM 0.042640457081943 0.478238745973267 no 1593 0.48299407235772 2342 735457 SGTC_3212 9128307 49.47 µM 0.0421828781783311 0.478410363290701 no 1594 0.483176455822528 2176 27243542 SGTC_1953 st076800 12.1 µM 0.0420619120259415 0.478455732937638 no 1595 0.483224671541723 2140 297591 SGTC_853 0419-0306 21 µM 0.041853451882661 0.478533918794758 no 1596 0.483307761936186 2283 762713 SGTC_563 tetrahydrosecaminediol 614 µM 0.041029542089273 0.478842945602998 no 1597 0.483636172252055 2325 334274 A psychoactive constituent of the cannabis plant. SGTC_1238 0333-0287 48.8 µM 0.0386558181749226 0.479733337225088 no 1598 0.484582399524267 2331 7226 SGTC_1060 3448-7350 82 µM 0.037996424918488 0.479980695936828 no 1599 0.484845266236646 2328 570178 SGTC_1736 st036774 51 µM 0.0359158173492659 0.480761245986901 no 1600 0.485674741791827 2344 1272247 SGTC_481 bay k-8644 50 µM 0.0358433701265267 0.480788426261276 no 1601 0.485703625454462 2316 2303 A calcium channel antagonist. SGTC_76 0433-0009 400.328 µM 0.0338096850207373 0.48155144689408 no 1602 0.486514456416233 2197 2841569 SGTC_190 3970-0790 3.722 µM 0.0334825457265974 0.481674193042241 no 1603 0.486644892260094 2362 2832352 SGTC_2088 5278280 127.392 µM 0.0311275159279009 0.482557875872103 no 1604 0.487583922880421 2323 791502 SGTC_1821 st053465 65.6 µM 0.0281877716748219 0.483661082098844 no 1605 0.488756195070078 2324 675086 SGTC_3156 9099931 49.47 µM 0.0277857963106203 0.483811942453565 no 1606 0.488916497246016 2328 18111053 SGTC_1397 3532-0190 20.1 µM 0.0259550181484012 0.48449905793523 no 1607 0.48964660833449 2349 5322280 SGTC_1053 3366-3204 134 µM 0.0233579958039224 0.485473833561979 no 1608 0.490682355174321 2344 3632071 YPR165W RHO1 SGTC_2801 7907800 81.82 µM 0.0229199605578419 0.485638255987816 no 1609 0.490857059177294 2352 6620925 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.0221766839036871 0.485917260456797 no 1610 0.49115350828293 2358 2333 A French combination drug. SGTC_2068 5226020 147 µM 0.0220938395608914 0.485948358246546 no 1611 0.491186550298167 2362 1810509 SGTC_790 1575-0012 79.1 µM 0.0216344605963867 0.486120799695234 no 1612 0.491369772189196 2363 378741 YLR208W SEC13 SGTC_2944 9067346 25.62 µM 0.021137766089219 0.486307251552975 no 1613 0.491567879317615 2351 6473075 SGTC_1785 bathophenanthroline 24 µM 0.0209934586138757 0.486361423032829 no 1614 0.491625436898564 2342 72812 An iron chelator. SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.0208507735317115 0.486414985731114 no 1615 0.49168234755332 2384 16623 A steroid. SGTC_1889 st059080 5.18 µM 0.0207538672623884 0.486451363614037 no 1616 0.491720999197479 2361 176925 Isolated from Daphnopsis sellowiana. SGTC_1217 1183-1422 255 µM 0.020061862481747 0.486711140250726 no 1617 0.491997011674257 2356 2849664 SGTC_982 1491-0518 27.5 µM 0.0159318628586228 0.488261643884394 no 1618 0.493644375169898 2363 3091256 SGTC_2571 chrysanthemic acid 100 µM 0.0146904751544233 0.488727727168914 no 1619 0.494139559132821 2344 2743 An insecticide. SGTC_506 n9-isopropylolomoucine 153 µM 0.0134999701002286 0.489174720856477 no 1620 0.494614454728574 2382 6610355 SGTC_2821 7996764 71.43 µM 0.0126786202605933 0.489483117422355 no 1621 0.494942097828705 2371 2987135 SGTC_1344 1488-0097 29.1 µM 0.0124263459142695 0.489577841475436 no 1622 0.495042732802869 2368 747966 SGTC_1944 st076371 56.9 µM 0.0114237972265615 0.489954284538268 no 1623 0.495442663408266 2374 24208455 SGTC_1896 st058441 89 µM 0.0100913331041772 0.490454620043143 no 1624 0.495974208886987 2369 688759 SGTC_657 3534-0529 86.7 µM 0.00992925313459031 0.490515481531489 no 1625 0.496038866199985 2378 1049549 SGTC_308 4092-1169 104 µM 0.00924563615798047 0.490772184058556 no 1626 0.496311577376275 2387 2268590 YDL196W YDL196W SGTC_2445 5742597 35.57 µM 0.00856637993598574 0.491027252880319 no 1627 0.496582550650641 2380 1774255 SGTC_2381 9035592 200 µM 0.00801506881477072 0.491234279491472 no 1628 0.496802484404939 2365 4749657 SGTC_185 k048-0037 25.491 µM 0.00774263227467919 0.491336584875868 no 1629 0.496911167485798 2397 6827589 SGTC_3305 9127027 53.8275 µM 0.00683892907700175 0.491675947593395 no 1630 0.497271683306195 2384 41905295 SGTC_2625 euphol 100 µM 0.0064513536893609 0.491821493518725 no 1631 0.497426300100386 2395 6708538 A triterpene alcohol. SGTC_283 0987-0079 11.7 µM 0.00635264335999847 0.49185856231724 no 1632 0.497465679017272 2383 411556 SGTC_3320 9137005 35.139 µM 0.00501797975205709 0.492359776780552 no 1633 0.497998124115956 2392 4908713 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.00461165042803027 0.492512370571473 no 1634 0.498160224183013 2398 6708630 An antioxidant. SGTC_2921 7974240 10.71 µM 0.00452734982797473 0.492544029138665 no 1635 0.498193854905516 2392 2979074 YDR527W RBA50 SGTC_1288 0973-0013 65.5 µM 0.00376231451804597 0.492831335524094 no 1636 0.498499057207561 2393 4315430 SGTC_402 epigallocatechin gallate 10 µM 0.00334211530601322 0.492989141488035 no 1637 0.498666691380572 2390 65064 An antioxidant. SGTC_2307 7538926 6.34 µM 0.00324564058337819 0.493025372760297 no 1638 0.498705179017618 2395 96582 SGTC_2975 9084847 53.72 µM 0.00287617243452869 0.493164127781429 no 1639 0.498852574792129 2381 27211724 SGTC_3106 9121286 49.47 µM 0.00276947306841985 0.493204199246283 no 1640 0.498895141510948 2390 15943471 SGTC_2909 7941780 10.49 µM 0.00274627012696769 0.493212913232663 no 1641 0.498904398110121 2400 1243215 SGTC_460 trequinsin 123 µM 0.00272511934653488 0.493220856522029 no 1642 0.498912836019124 2401 5537 A vasodilator. SGTC_1279 0874-0590 65.2 µM 0.0026667853150839 0.493242764195251 no 1643 0.498936107846081 2396 3523074 SGTC_1229 0139-0193 12.2 µM 0.0023945783739807 0.493344993309577 no 1644 0.499044702355831 2400 3090752 SGTC_640 3381-0960 37.1 µM 0.000732952287426256 0.49396903718902 no 1645 0.49970759436921 2404 1745025 SGTC_3050 9093513 49.47 µM -0.000411326773225276 0.494398793776809 no 1646 0.499835904363727 2407 25236664 SGTC_2772 vinpocetine 57.06 µM -0.00220979438924317 0.495074256735385 no 1647 0.499118420304624 2410 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.0027852296916622 0.495290380038588 no 1648 0.498888855551985 2413 6708760 SGTC_1317 1273-0028 910 nM -0.00288286929787372 0.495327051883481 no 1649 0.498849903141271 2414 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1487 3970-0795 2.82 µM -0.00371626538182989 0.495640063446352 no 1650 0.498517428026538 2417 3765103 SGTC_4 0960-0234 25.671 µM -0.00415791720062595 0.495805942607265 no 1651 0.498341235809792 2358 6821112 SGTC_1211 1056-0033 32.3 µM -0.00444477473512778 0.495913683269603 no 1652 0.498226797269872 2416 6741922 SGTC_2665 lovastatin 100 µM -0.00446077299649323 0.495919692056567 no 1653 0.498220414950272 2413 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_3215 9129942 49.47 µM -0.00511000120672771 0.496163536445005 no 1654 0.497961413337705 2418 17682944 SGTC_3333 9141820 12.094 µM -0.00523332168106842 0.496209854692041 no 1655 0.497912216244402 2421 1939433 SGTC_546 peri-Naphthalide 147 µM -0.00641011855877641 0.496651853270957 no 1656 0.497442750197267 2426 223824 A penicillin ester. SGTC_1513 0337-0559 19 µM -0.00734875880570258 0.497004404472875 no 1657 0.497068295791374 2428 775073 SGTC_300 r073-0011 5.04 µM -0.00746692845424849 0.497048788903151 no 1658 0.497021154215828 2424 2735780 SGTC_2941 9056145 11.23 µM -0.00801558958038082 0.497254866075388 no 1659 0.496802276656193 2416 2119517 SGTC_1085 doxorubicin 7.67 µM -0.00825356832037829 0.497344251144229 no 1660 0.496707340016291 2421 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2873 9040596 71.43 µM -0.00840744955261883 0.497402049170621 no 1661 0.496645952416757 2459 6463863 SGTC_1391 3442-0225 151 µM -0.0086401215349846 0.497489441226544 no 1662 0.496553133097687 2425 5227075 SGTC_1039 k821-0043 94 µM -0.00958868787229452 0.497845725817795 no 1663 0.496174725612085 2405 15992768 SGTC_1954 st077032 68.9 µM -0.0105469037615158 0.498205636555601 no 1664 0.495792472167939 2449 698907 SGTC_214 4373-3496 70 µM -0.0111048994277611 0.498415223243669 no 1665 0.495569877151747 2434 3779166 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.0115244517456606 0.498572810029024 no 1666 0.49540251070815 2445 7104 SGTC_2221 6807166 181.081 µM -0.0118846575690098 0.498708106034494 no 1667 0.495258819219306 2433 674925 SGTC_2398 5228213 48.84 µM -0.0119005646652356 0.498714080862532 no 1668 0.495252473654819 2423 80771 YMR134W ERG29 SGTC_928 2764-0428 58.7 µM -0.0121875524801433 0.498821875747677 no 1669 0.49513799038562 2481 662578 SGTC_3109 9122853 49.47 µM -0.0125993818230638 0.498976562242953 no 1670 0.494973706866877 2461 1234709 SGTC_2570 licareol 100 µM -0.0127359059590652 0.499027841868696 no 1671 0.494919245986595 2449 443158 SGTC_229 benomyl 22.8748 µM -0.012948771136632 0.499107795870172 no 1672 0.49483433206993 2441 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2191 5911152 200 µM -0.0129552849907423 0.499110242530686 no 1673 0.494831733636076 2427 2875902 SGTC_2757 clomiphene 4.22 µM -0.012964074085553 0.49911354379154 no 1674 0.494828227588988 2431 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1862 st057513 3.81 µM -0.0134100302870099 0.499281048914534 no 1675 0.494650332275017 2430 5393163 SGTC_786 4544-0069 423 µM -0.0142351187957012 0.49959095982253 no 1676 0.494321201037157 2486 748821 YLR208W SEC13 SGTC_290 2043-6722 48.1 µM -0.0150208829786112 0.499886100380723 no 1677 0.494007760026831 2443 773758 YLR208W SEC13 SGTC_368 fentichlor 4.58 µM -0.0150792186639289 0.499908011827716 no 1678 0.493984490091021 2444 7329 A pesticide. SGTC_2311 7694451 200 µM -0.0155690259268996 0.499908011827716 no 1679 0.493789108208513 2450 2163142 SGTC_1029 k015-0030 64.7 µM -0.0157095781406348 0.499855219058946 no 1680 0.493733042844767 2499 2208316 SGTC_3017 9080681 49.47 µM -0.0161259668381937 0.499698819461573 no 1681 0.493566948832837 2458 16451914 SGTC_247 mechlorethamine 29.705 µM -0.016626637387854 0.499510762853823 no 1682 0.493367236965598 2436 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2251 lansoprazole 556 µM -0.0170566933547655 0.499349229838421 no 1683 0.493195693788903 2450 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1091 telmisartan 47.6 µM -0.0170812195937928 0.499340017558214 no 1684 0.493185910660434 2480 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2418 pentamidine 31.67 µM -0.0174665611371927 0.499195279791523 no 1685 0.493032204561011 2431 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2985 9022375 71.43 µM -0.0175150564947022 0.499177064504018 no 1686 0.493012860671648 2550 4939335 SGTC_3003 9075612 71.4286 µM -0.0185117205647109 0.498802709051656 no 1687 0.492615313754891 2467 6501993 SGTC_1651 st011928 86.1 µM -0.0187021057463946 0.49873119887736 no 1688 0.492539374203398 2465 720198 SGTC_276 colchicine 750 µM -0.0188271458805245 0.498684232839819 no 1689 0.492489499188727 2488 2833 A microtubule depolymerizer. SGTC_3241 9133421 49.47 µM -0.0207042859531731 0.497979167126478 no 1690 0.4917407750288 2442 17018221 SGTC_899 1083-0020 478 µM -0.021144276929557 0.497813904557823 no 1691 0.491565282448514 2456 767123 SGTC_3335 9143315 29.6265 µM -0.0211683975901375 0.497804844740963 no 1692 0.491555661850464 2455 4899691 SGTC_2977 9011197 71.43 µM -0.0216589618455859 0.497620587091179 no 1693 0.491359999894788 2471 2704722 SGTC_3235 9132602 49.47 µM -0.0232268758030915 0.497031676722643 no 1694 0.490734650298462 2507 4912240 SGTC_3153 9100258 49.47 µM -0.0232791883032634 0.49701202818903 no 1695 0.490713786271741 2461 25236848 SGTC_2427 5545055 42.75 µM -0.0238446563175377 0.496799639323517 no 1696 0.490488259786439 2451 5372858 SGTC_1726 st035556 14.5795 µM -0.0251602068258811 0.496305524307498 no 1697 0.489963588626313 2616 5919439 SGTC_3203 9113543 49.47 µM -0.0262522294367733 0.49589536966434 no 1698 0.489528078575702 2528 17018012 SGTC_13 0199-0087 65 µM -0.027210958200322 0.495535282647878 no 1699 0.489145737781711 2460 4589825 SGTC_1428 4049-0204 61.7 µM -0.0282089068663592 0.495160468974933 no 1700 0.488747766700129 2458 X1428 SGTC_2008 4012253 172 µM -0.0286741388295375 0.494985736676739 no 1701 0.488562241054396 2473 603940 SGTC_2411 st077133 39.94 µM -0.030466297372736 0.494312645220276 no 1702 0.487847585848709 2634 1403142 YNL221C POP1 SGTC_2687 chenodiol 100 µM -0.0312797270797024 0.494007145899233 no 1703 0.487523228971468 2476 5702181 A cholesterol synthesis inhibitor. SGTC_2567 aureobasidin a 60 nM -0.0312978329288897 0.494000345935328 no 1704 0.487516009317546 2551 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_575 k072-0246 11.9 µM -0.0315150467062179 0.493918767691786 no 1705 0.487429396284598 2466 6796779 SGTC_667 1498-1044 59 µM -0.0320210194360009 0.493728742217357 no 1706 0.487227644202699 2491 6739982 SGTC_694 1315-0438 43.2 µM -0.033726065716553 0.493088397825357 no 1707 0.48654779667826 2491 6793154 SGTC_1668 st014914 51.6 µM -0.0357578824546045 0.492325355449295 no 1708 0.485737708252531 2480 2839556 SGTC_2100 5377183 190 µM -0.0359415664841508 0.492256374832974 no 1709 0.485664476001282 2514 2844202 SGTC_2170 morpholine 200 µM -0.0368212651855234 0.491926016431942 no 1710 0.4853137591891 2498 121171 Reacts with secondary amines. SGTC_2755 lomerizine 42.69 µM -0.0370138748999164 0.491853685309946 no 1711 0.485236971375688 2487 3949 A calcium channel blocker. SGTC_2947 9072639 7.68 µM -0.0385260060002998 0.491285841104147 no 1712 0.484634148541017 2499 16488146 SGTC_1143 3454-2408 5.08 µM -0.0391874598572189 0.491037453615098 no 1713 0.484370465771065 2461 X1143 SGTC_3337 9144342 33.5465 µM -0.0394552173052477 0.490936906994274 no 1714 0.484263728553194 2520 17682949 SGTC_1779 st039427 55 µM -0.0398595999921215 0.490785056802469 no 1715 0.484102530012171 2465 1124498 SGTC_301 4119-0100 24.5 µM -0.0399152005253487 0.490764178288438 no 1716 0.484080366246999 2484 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_316 k060-0003 58.6 µM -0.0399261003732909 0.490760085297775 no 1717 0.484076021300365 2550 6152314 SGTC_3046 9092212 49.47 µM -0.0406446537660027 0.490490264220877 no 1718 0.483789592496085 2479 25236637 SGTC_1360 1598-0022 39.8 µM -0.0407877626314584 0.490436526505613 no 1719 0.483732547623375 2522 761525 SGTC_1300 1094-0077 113 µM -0.0416717046173435 0.490104608097502 no 1720 0.483380205402222 2480 5532636 SGTC_770 0389-1121 67.2 µM -0.0417099719071938 0.490090238961509 no 1721 0.483364952224079 2614 6753108 SGTC_3299 9121982 43.1275 µM -0.0429184228126354 0.489636479665988 no 1722 0.48288328150009 2516 17594604 YPL160W CDC60 SGTC_1486 3970-0793 4.53 µM -0.0431265814234394 0.48955831986035 no 1723 0.482800315047686 2530 2844330 SGTC_168 3970-0862 530.542 µM -0.043378477904135 0.489463737809563 no 1724 0.482699916846992 2526 3135186 SGTC_1496 4469-0713 57.4 µM -0.0433937385969025 0.489458007746034 no 1725 0.482693834438738 2479 746691 SGTC_1659 st012954 42.1 µM -0.04346885083707 0.489429804739117 no 1726 0.482663897238616 2543 24207262 SGTC_2171 5739187 198.077 µM -0.0442082380969494 0.489152183802523 no 1727 0.482369207711676 2481 2262761 SGTC_2927 9011802 47.9 µM -0.0451373760698146 0.48880332381224 no 1728 0.481998904986802 2522 43912568 SGTC_1076 itraconazole 331 nM -0.0464299391406774 0.488318024252907 no 1729 0.481483787127012 2483 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_419 nsc-638432 893 µM -0.0470915645268433 0.488069620191677 no 1730 0.481220125206466 2527 368090 SGTC_1636 st007707 68.9 µM -0.0475742382295891 0.487888405591421 no 1731 0.48102778184477 2516 403051 SGTC_1780 st038448 24.544 µM -0.0489569339504854 0.487369301468074 no 1732 0.480476808243422 2645 728868 YDL195W SEC31 SGTC_2284 7945075 39.21 µM -0.0491410374995558 0.487300185245018 no 1733 0.480403449849846 2547 1245402 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.0498644297094979 0.487028612785337 no 1734 0.480115211501723 2611 61125 An anti-inflammatory. SGTC_2614 arthonioic acid 13.39 µM -0.0501650906355463 0.486915741854117 no 1735 0.479995415074407 2484 6710684 SGTC_798 1287-0182 476 µM -0.0502139218232327 0.48689741026702 no 1736 0.479975958769562 2496 1649755 SGTC_699 0375-0592 111 µM -0.0513779365597597 0.486460438854525 no 1737 0.479512182811908 2488 762578 SGTC_3117 9124945 49.47 µM -0.0516086373394078 0.486373835639806 no 1738 0.479420268455954 2482 17592065 SGTC_1738 st035555 74 µM -0.0519970528136616 0.486228029052762 no 1739 0.479265520876499 2565 5331140 SGTC_5 0352-0601 109.883 µM -0.0551791228452156 0.485033588582726 no 1740 0.477997880573748 2458 762456 SGTC_2453 5731132 22.18 µM -0.0557181717267986 0.484831261038995 no 1741 0.477783161522618 2530 1362040 SGTC_2352 9027995 87.8 µM -0.0563580530285692 0.484591091953037 no 1742 0.477528286324059 2549 2997347 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.0569636954726848 0.48436377901578 no 1743 0.477287057488058 2492 6708561 SGTC_596 1155-0152 116 µM -0.0570236789214492 0.484341265984717 no 1744 0.477263166388248 2515 280313 SGTC_150 3970-0969 77.2 µM -0.0575631192004524 0.484138805123449 no 1745 0.477048313775799 2643 6615640 SGTC_3184 9108758 49.47 µM -0.0579831681414937 0.483981156635728 no 1746 0.476881017922414 2479 902885 SGTC_2146 5545642 200 µM -0.0583893498268216 0.483828715046296 no 1747 0.476719248953444 2510 825326 SGTC_1709 st033179 39.1045 µM -0.0584866087869172 0.483792213724676 no 1748 0.476680514437763 2498 573381 SGTC_3182 9108849 49.47 µM -0.0599541767022044 0.483241451636973 no 1749 0.476096065345956 2562 17133045 SGTC_3234 9132280 49.47 µM -0.06020332479499 0.483147952245955 no 1750 0.47599684885838 2571 17612295 SGTC_2943 9068529 45.32 µM -0.0608929539685367 0.482889155563922 no 1751 0.475722230476423 2498 3270634 SGTC_3030 9087619 49.47 µM -0.0647448176129114 0.48144380489876 no 1752 0.474188589181033 2535 25236973 SGTC_1853 st056710 91.2 µM -0.0663065534582649 0.480857856737169 no 1753 0.473566882902076 2648 269167 SGTC_2746 daunorubicin 9.88 µM -0.0671300254207403 0.480548914604703 no 1754 0.473239095486227 2500 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_446 go6976 132 µM -0.070443101208799 0.479306067275965 no 1755 0.471920493314122 2537 3501 A protein kinase C inhibitor. SGTC_1448 4255-0083 152 µM -0.0706857168876258 0.479215061648029 no 1756 0.471823944336552 2660 5399660 SGTC_2317 5986382 200 µM -0.070892630446253 0.479137448812934 no 1757 0.471741604335729 2560 877883 SGTC_1421 4029-0249 71.4 µM -0.0716529284674634 0.478852269460776 no 1758 0.471439058730294 2583 2894095 SGTC_559 1550-0661 158 µM -0.0726447969404655 0.478480246898256 no 1759 0.471044389032244 2600 5830875 SGTC_2680 butyl paraben 22.24 µM -0.0746433611619491 0.477730697752358 no 1760 0.47024923655737 2531 7184 An antifungal and steroid mimetic. SGTC_1135 dihydrocapsaicin 536.708 nM -0.074737441337906 0.477695415484948 no 1761 0.470211808542195 2517 107982 A Capsaicinoid. SGTC_2780 5215298 71.43 µM -0.0758880939561479 0.477263908056431 no 1762 0.46975406459525 2553 2834131 SGTC_3047 9092122 49.47 µM -0.0761269280064349 0.477174345976048 no 1763 0.469659058423615 2580 17173831 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.0765884682451029 0.477001272987702 no 1764 0.469475466506989 2625 5393153 SGTC_3298 9116858 71.43 µM -0.0791444187482941 0.476042896452936 no 1765 0.468458876622028 2641 2506942 SGTC_2524 avocatin b 10.57 µM -0.0792071852028414 0.476019363329201 no 1766 0.468433914792722 2595 6710748 SGTC_1183 1254-0324 198 µM -0.0809177976007295 0.475378033261275 no 1767 0.46775366296997 2635 5799357 SGTC_3034 9090421 49.47 µM -0.0821675626080171 0.47490952089733 no 1768 0.467256733742618 2536 17173761 SGTC_585 0kpi-0023 191 µM -0.0822731746302217 0.474869930604469 no 1769 0.46721474281511 2587 64601 SGTC_201 4262-0159 12.803 µM -0.0823259431453572 0.47485014960692 no 1770 0.467193762396269 2618 1341029 SGTC_1770 st043884 66.3 µM -0.0840526237956385 0.474202914304845 no 1771 0.466507296009953 2557 670149 SGTC_648 0375-0473 33.3 µM -0.0854149052412056 0.473692319698462 no 1772 0.465965771899179 2567 1713139 SGTC_2879 9041815 71.43 µM -0.0855522030527381 0.473640861700913 no 1773 0.46591119776048 2559 4942971 SGTC_985 1493-0307 8.71 µM -0.087451965876528 0.472928893028658 no 1774 0.465156132381624 2584 3278274 SGTC_128 0906-2981 13.371 µM -0.0874792852220253 0.472918655261073 no 1775 0.465145275149356 2608 6740226 SGTC_1916 st067606 49.2 µM -0.0882464868510719 0.472631158193713 no 1776 0.464840385121853 2654 19590279 SGTC_3174 9107204 49.47 µM -0.0883228037665469 0.472602560375001 no 1777 0.464810057497625 2638 3938802 SGTC_26 0302-0163 425.158 µM -0.088424977529449 0.472564273582957 no 1778 0.464769454925565 2581 3100915 SGTC_1241 0364-0022 50.8 µM -0.0885559618579844 0.472515191199029 no 1779 0.464717403932652 2639 4563895 SGTC_2517 totarol 10 µM -0.0886221976184912 0.472490371525878 no 1780 0.464691083173213 2614 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_391 gliotoxin 8.33 µM -0.0888312595685478 0.472412033135989 no 1781 0.464608007171791 2664 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2489 cantharidin 73.42 µM -0.0888628734496443 0.472400187072472 no 1782 0.464595444738627 2583 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2645 abamectin 100 µM -0.0891472613755136 0.472293624936529 no 1783 0.464482438869706 2587 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1293 1000-1278 195 µM -0.0891502367952218 0.472292510036517 no 1784 0.464481256556546 2637 678847 SGTC_2788 5282734 71.43 µM -0.0893348334603161 0.472223341455233 no 1785 0.464407905815554 2643 743706 SGTC_23 0213-0011 39.996 µM -0.0902306532338244 0.471887688696994 no 1786 0.464051962956309 2633 627608 SGTC_1927 st060202 13.8 µM -0.0905959440046534 0.471750824411355 no 1787 0.463906827447743 2544 688887 SGTC_2461 5755302 26.15 µM -0.0940590778170485 0.470453452540232 no 1788 0.46253111369138 2696 2788904 SGTC_1647 st011722 22.4 µM -0.0946480376124587 0.470232845083316 no 1789 0.462297196287587 2660 2854783 SGTC_2713 st079149 53.4 µM -0.095197784247055 0.47002693399485 no 1790 0.462078864955148 2628 3103253 SGTC_487 nimodipine 119 µM -0.0960180015708491 0.469719731310722 no 1791 0.461753137716922 2553 4497 L-type voltage-gated calcium channels inhibitor SGTC_66 0109-0187 42.4 µM -0.096372666924078 0.469586901174212 no 1792 0.461612299847241 2546 759417 SGTC_1922 5578187 25 µM -0.0985588825505093 0.468768189638335 no 1793 0.460744258989649 2756 1350412 SGTC_719 2810-4230 27.3 µM -0.100130949685711 0.468179550767336 no 1794 0.460120182252127 2586 721079 SGTC_1547 harmine 94.2 µM -0.100639162065213 0.467989272463682 no 1795 0.45991845383835 2582 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1375 2910-0797 186 µM -0.101509624713099 0.467663382115516 no 1796 0.459572958804765 2661 742508 SGTC_1151 3909-8316 15.3 µM -0.102179310283327 0.467412674937468 no 1797 0.45930717489626 2688 800431 SGTC_342 k048-0088 23.3 µM -0.102179449214142 0.4674126229279 no 1798 0.459307119759468 2566 6820570 SGTC_558 k064-0027 21.3 µM -0.102404538921273 0.467328360004055 no 1799 0.459217790538237 2669 5088526 SGTC_2217 6934799 96.0675 µM -0.102974666028722 0.46711493798111 no 1800 0.458991538813056 2602 675606 SGTC_105 0111-0055 734.78 µM -0.102991870243588 0.467108497882595 no 1801 0.458984711623565 2676 5179370 SGTC_533 1222-0222 6.71 µM -0.103026972411098 0.467095358023607 no 1802 0.458970781984494 2767 3982874 SGTC_1583 clindamycin 39.6 µM -0.103562619525328 0.466894852710136 no 1803 0.458758226698734 2600 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2799 7812892 81.82 µM -0.10421326577166 0.466651311821002 no 1804 0.458500053366132 2668 20205235 SGTC_1201 1889-3372 45.9 µM -0.105190171960023 0.466285673305106 no 1805 0.458112454548381 2636 5392199 SGTC_515 4092-1064 102 µM -0.105905779170615 0.466017852361739 no 1806 0.457828554371649 2655 717353 SGTC_1240 0356-0016 42.1 µM -0.106646513455214 0.46574064364743 no 1807 0.457534708287998 2667 4305613 SGTC_2931 9014674 55.67 µM -0.107703054237987 0.465345277875866 no 1808 0.457115623338939 2616 2996810 SGTC_1308 1187-1617 41.4 µM -0.108207404076838 0.465156558284202 no 1809 0.456915585920238 2575 2882570 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.108368943199871 0.465096114599457 no 1810 0.456851517879021 2605 688664 SGTC_1 0258-0098 57.368 µM -0.108891166339186 0.464900717973588 no 1811 0.456644406610556 2628 6790032 YDR047W HEM12 SGTC_908 3448-7491 47.7 µM -0.109424608341822 0.464701132401432 no 1812 0.456432858152861 2606 1203031 SGTC_259 usnic acid 108.925 µM -0.111269520190552 0.464010933481882 no 1813 0.455701312326014 2775 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2627 acetyl isogambogic acid 100 µM -0.111300036264786 0.46399951803548 no 1814 0.455689213325044 2698 6857789 A caspase activator and apoptosis inducer. SGTC_3073 9114972 49.47 µM -0.111869429287486 0.463786525063274 no 1815 0.45546346815472 2634 41905075 SGTC_3099 9120367 49.47 µM -0.113288173739226 0.463255860296981 no 1816 0.454901046433978 2595 24824940 SGTC_967 1306-0166 352 µM -0.113471712840948 0.463187214398857 no 1817 0.4548282940487 2638 4437607 SGTC_2742 clothiapine 36.27 µM -0.115372854425915 0.462476228745682 no 1818 0.454074797145936 2599 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_3045 9092950 49.47 µM -0.116664620050933 0.461993204719562 no 1819 0.453562913938977 2621 44120432 SGTC_618 k072-0232 33.2 µM -0.117002303620037 0.461866945455565 no 1820 0.453429113998329 2677 5872756 YGL099W LSG1 SGTC_597 k018-0003 82.8 µM -0.11749668784064 0.461682103041768 no 1821 0.453233234292702 2723 6786234 SGTC_1917 st066507 28.5 µM -0.118486311110229 0.461312123512354 no 1822 0.452841170421005 2606 3156428 SGTC_595 3909-8003 73.7 µM -0.119337423551521 0.460993954265704 no 1823 0.452504017813465 2701 699517 SGTC_2734 clemastine 41.6 µM -0.119970439941022 0.46075733150257 no 1824 0.452253282154601 2607 26987 Clemastine is a selective histamine H1 antagonist. SGTC_3091 9116372 49.47 µM -0.120327198986027 0.460623980391127 no 1825 0.452111979482252 2775 17169793 SGTC_3339 9145883 14.936 µM -0.120699508396748 0.460484821511288 no 1826 0.451964524196157 2690 2030670 SGTC_3080 9117754 49.47 µM -0.121590454281304 0.460151830453475 no 1827 0.451611686886706 2739 9550191 SGTC_3138 9097216 49.47 µM -0.121598606997463 0.460148783504181 no 1828 0.451608458379081 2580 25237486 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.12168215914897 0.460117557338061 no 1829 0.451575371583394 2658 279621 SGTC_1152 3909-8331 15.9 µM -0.121788050291749 0.460077982715215 no 1830 0.45153343899209 2625 16001939 SGTC_1413 3910-0535 34.4 µM -0.121804760618011 0.460071737612769 no 1831 0.451526821799818 2734 2876951 SGTC_3040 9091894 49.47 µM -0.122679938043796 0.459744673860382 no 1832 0.451180275483924 2656 25236966 SGTC_125 0133-0007 11.75 µM -0.123199131406269 0.459550658257782 no 1833 0.450974706683676 2729 26541 SGTC_354 2783-3500 4.88 µM -0.123978514024195 0.459259431513751 no 1834 0.450666143560967 2651 6740761 SGTC_759 3486-0358 89.3 µM -0.12459320185631 0.459029760592134 no 1835 0.450422805295835 2618 875103 SGTC_701 4424-0219 185 µM -0.124751466300003 0.458970629143687 no 1836 0.450360155701981 2687 2911779 SGTC_1572 epiandrosterone 68.9 µM -0.125213113558282 0.458798151681735 no 1837 0.450177417916169 2651 441302 A steroid. SGTC_2516 gossypol 71.55 µM -0.126684814864567 0.458248356730502 no 1838 0.449594932488086 2736 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_542 3381-0244 89.3 µM -0.127156503870785 0.458072161035761 no 1839 0.449408265369868 2802 1112843 SGTC_189 3970-0742 2.116 µM -0.1274192014437 0.457974036006428 no 1840 0.449304309776314 2640 2891807 SGTC_3244 9134489 49.47 µM -0.128293841266359 0.457647351602714 no 1841 0.44895821939425 2720 16584271 SGTC_1810 st050138 53 µM -0.130201005277521 0.456935111338392 no 1842 0.448203699627554 2624 3444541 SGTC_1140 3229-1848 2.98 µM -0.133418072428416 0.455733995578835 no 1843 0.446931376724133 2731 2849525 SGTC_2819 7996655 46.38 µM -0.133585731337561 0.455671409881674 no 1844 0.446865083897247 2734 6456960 SGTC_1570 verbenone 133 µM -0.133935551574179 0.455540828397213 no 1845 0.446726768727478 2748 29025 A natural terpanoid with antifungal properties. SGTC_452 diindolylmethane 8 µM -0.134206431178624 0.455439717302977 no 1846 0.44661967028801 2739 3071 Inhibits expression of several cancer promoting factors. SGTC_77 0828-0286 12.516 µM -0.134214037054365 0.455436878303179 no 1847 0.446616663187449 2614 745345 SGTC_2107 5363541 170.161 µM -0.13426554450578 0.455417652484402 no 1848 0.44659629900102 2644 244052 SGTC_2852 9023854 51.95 µM -0.13613018770276 0.454721721085602 no 1849 0.445859181661747 2788 19798528 SGTC_1739 st037196 92.5 µM -0.136715055324667 0.454503462412987 no 1850 0.445628014424057 2718 612214 SGTC_448 monastrol 171 µM -0.137128994492299 0.454348998467339 no 1851 0.445464417329549 2679 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_632 0781-2353 4.65 µM -0.139256287347532 0.453555295465026 no 1852 0.44462381544103 2735 6811515 YHR007C ERG11 SGTC_3206 9114350 49.47 µM -0.139623673608548 0.45341824061104 no 1853 0.444478667503067 2730 17087243 SGTC_1468 k284-1086 134 µM -0.140077815121521 0.453248829047044 no 1854 0.444299254362352 2674 15996457 SGTC_1957 st077035 62.4 µM -0.140767085818947 0.452991721875623 no 1855 0.444026972907045 2670 705593 SGTC_2804 7954240 19.48 µM -0.145668410598707 0.451164036834937 no 1856 0.442091580004154 2794 828705 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.146056269173412 0.451019449552912 no 1857 0.441938484134447 2660 442882 SGTC_2690 usnic acid 100 µM -0.147876046586325 0.450341153623794 no 1858 0.441220296202825 2821 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_622 1348-1566 26.3 µM -0.149379982780348 0.449780692343532 no 1859 0.440626902965869 2757 7340407 SGTC_2278 7948257 134.34 µM -0.149733094802978 0.449649115057456 no 1860 0.440487598319728 2674 1247028 SGTC_1415 3966-0071 78.1 µM -0.150341781688492 0.449422317974249 no 1861 0.440247485276605 2678 2893185 SGTC_3164 9100705 49.47 µM -0.150724045631913 0.449279894650809 no 1862 0.440096702127926 2821 17174235 SGTC_1008 4106-0037 6 µM -0.151368330199222 0.449039862875842 no 1863 0.439842585207521 2651 2905394 SGTC_115 0527-0192 112.043 µM -0.151492079046468 0.448993761691464 no 1864 0.439793779366489 2738 4233931 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.151624463347286 0.448944444232339 no 1865 0.439741568764689 2751 16725076 SGTC_2353 9059630 146.67 µM -0.153888082015592 0.448101295317575 no 1866 0.438848990669653 2784 4779114 SGTC_2072 5231554 129 µM -0.153890692617305 0.448100323059589 no 1867 0.438847961449656 2774 789545 SGTC_2642 cholecalciferol 100 µM -0.15521641032548 0.447606630689148 no 1868 0.43832535575307 2762 9821465 A vitamin D precursor, similar to steriods. SGTC_1184 1269-1718 139 µM -0.155420822254656 0.44753051564532 no 1869 0.438244784917106 2814 5403821 SGTC_3343 9148379 18.9835 µM -0.155568676954844 0.447475461515652 no 1870 0.438186508226615 2811 1955036 SGTC_2243 6634756 200 µM -0.155597206069965 0.447464838732707 no 1871 0.438175263676355 2969 885676 SGTC_2390 9097792 176.6 µM -0.155766525164775 0.447401793739781 no 1872 0.438108528772409 2697 4497149 SGTC_586 0957-0265 8.15 µM -0.156804491826076 0.447015341914952 no 1873 0.437699466341206 2676 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1219 1469-0211 33.1 µM -0.158560522316509 0.446361658010231 no 1874 0.437007566925101 2736 6822282 SGTC_2440 5628896 157.78 µM -0.159811967837503 0.445895895140698 no 1875 0.436514598141958 2709 5522048 SGTC_2179 6298986 200 µM -0.160863542198813 0.44550457799127 no 1876 0.436100438695533 2793 738374 SGTC_512 prima-1 270 µM -0.163676848965113 0.444457938121931 no 1877 0.43499277179244 2864 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2958 9077254 16.72 µM -0.163944930507704 0.444358223326003 no 1878 0.43488724808342 2872 16457351 SGTC_673 1082-0474 110 µM -0.163955683803202 0.44435422363631 no 1879 0.434883015409691 2710 3098046 SGTC_2678 equilin 100 µM -0.164500035807723 0.444151759248518 no 1880 0.434668759280539 2781 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.165465059234763 0.443792867649398 no 1881 0.434288974704683 2655 4000243 SGTC_1569 carminic acid 40.6 µM -0.166538934137914 0.443393548452114 no 1882 0.433866422973747 2791 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_479 n-linoleoylglycine 10 µM -0.1673155858355 0.443104787168518 no 1883 0.433560870639284 2706 6433346 An anti-infammatory. SGTC_2702 st077768 96.8 µM -0.167490820929944 0.443039638440302 no 1884 0.433491934675092 2778 6484119 SGTC_1474 0330-0125 5.35 µM -0.167524476937546 0.443027126019672 no 1885 0.433478694925562 2739 X1474 SGTC_1220 1838-0075 193 µM -0.167889933494473 0.442891262520533 no 1886 0.433334934813659 2727 5529645 SGTC_870 0573-2213 57.6 µM -0.16890924070507 0.442512356584529 no 1887 0.432934015303453 2688 3916321 SGTC_1297 1068-0111 14.1 µM -0.169551530669301 0.442273625832513 no 1888 0.432681421709846 2692 767057 SGTC_2904 7225135 42.03 µM -0.169813559880498 0.442176239028286 no 1889 0.432578381286429 2809 4446116 SGTC_2264 7948757 110.76 µM -0.169841660826718 0.44216579512779 no 1890 0.432567331136378 2686 2971411 SGTC_1444 4112-3581 28 µM -0.16992139941541 0.442136159978555 no 1891 0.432535975775845 2707 2877249 SGTC_2158 5657123 3.6195 µM -0.170332699889136 0.441983303742731 no 1892 0.432374248104366 2681 2858827 SGTC_2403 6032726 181.2 µM -0.170737716666859 0.441832791229202 no 1893 0.432215002319689 2783 2881040 SGTC_3183 9108214 49.47 µM -0.170816697732815 0.441803441228488 no 1894 0.432183949575269 2715 4974831 SGTC_1882 5615643 20 µM -0.171443873031558 0.441570389187762 no 1895 0.431937379866308 2676 2253075 SGTC_898 1000-0849 28.3 µM -0.172334473612693 0.441239485732436 no 1896 0.431587291871655 2691 6751807 SGTC_24 0417-1663 219 µM -0.172416808680094 0.441208896130991 no 1897 0.431554929321496 2784 4329390 SGTC_1629 st005085 44.9 µM -0.172520576041469 0.441170344379041 no 1898 0.43151414326685 2713 24207091 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.173603710396897 0.440767970584703 no 1899 0.431088457914208 2852 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1295 1013-0063 9.78 µM -0.174298142945536 0.440510027842733 no 1900 0.430815579310792 2768 6826038 SGTC_1410 3909-8106 77.9 µM -0.174775775791454 0.440332628674801 no 1901 0.430627911729138 2788 1039210 SGTC_856 0433-0016 11.3 µM -0.175455600005604 0.440080153615712 no 1902 0.430360827799504 2783 3911780 SGTC_930 2810-3379 265 µM -0.175546955249411 0.440046227698924 no 1903 0.430324939303381 2916 1015764 SGTC_2813 7971799 71.43 µM -0.176329855823153 0.439755505817082 no 1904 0.430017403969514 2841 2234054 SGTC_804 1595-0054 20.9 µM -0.178782341338794 0.438845012116451 no 1905 0.429054305725329 2732 761523 Stimulates phospholipase C. SGTC_3101 9120531 49.47 µM -0.180502488146591 0.438206594422375 no 1906 0.428379050609776 2956 24824904 SGTC_1955 wogonin 32.4 µM -0.181218743856193 0.437940809592908 no 1907 0.428097941353981 2981 5281703 A flavanone. SGTC_737 1950-0117 57.9 µM -0.181843610073963 0.437708960009802 no 1908 0.427852729574743 2773 5393513 SGTC_84 0443-0269 128.823 µM -0.182456033581833 0.437481747903435 no 1909 0.427612427633194 2733 6150058 SGTC_2180 6301957 200 µM -0.183463294015412 0.437108094242374 no 1910 0.427217258527429 2772 845462 SGTC_678 1218-2179 85.9 µM -0.185053068388371 0.436518465277789 no 1911 0.426593705875233 2722 6820081 YOR116C RPO31 SGTC_952 1185-0122 232 µM -0.188025099645778 0.435416552424172 no 1912 0.425428487704237 2689 678600 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.188377086642665 0.435286082457725 no 1913 0.425290530176145 2713 88881 An O-methylated flavonoid and antioxidant. SGTC_3025 9087895 49.47 µM -0.188649405562106 0.435185147651701 no 1914 0.425183803971576 2851 17173641 SGTC_1139 k015-0024 46.9 µM -0.189192307573614 0.434983934031073 no 1915 0.424971048229696 2732 2766652 SGTC_1409 3909-8004 61.9 µM -0.189353561820753 0.434924172249268 no 1916 0.424907859141064 2779 2119279 SGTC_1865 st057639 52.2 µM -0.189585629526921 0.434838169188526 no 1917 0.42481692447741 2713 688818 SGTC_647 0140-0236 81 µM -0.190553429910376 0.434479540784354 no 1918 0.424437739532752 2776 990837 SGTC_2705 st078069 42.8 µM -0.190952095260086 0.434331826891739 no 1919 0.424281562452292 2821 1530061 SGTC_17 0960-0276 49.807 µM -0.191059515762174 0.434292026904666 no 1920 0.424239482521826 2729 6821114 SGTC_965 1291-5240 308 µM -0.191322772073711 0.434194491564596 no 1921 0.424136360541408 2860 2834598 SGTC_992 3909-8734 162 µM -0.192496011517211 0.433759860146544 no 1922 0.423676845920159 2792 4288319 SGTC_3204 9114183 49.47 µM -0.192527396013098 0.433748234727286 no 1923 0.423664555192881 2711 17027248 SGTC_1458 k015-0034 6.33 µM -0.192889252337764 0.433614200346248 no 1924 0.423522851181922 2798 3598957 SGTC_2988 9073640 71.4286 µM -0.19388144651063 0.433246723160014 no 1925 0.423134355790389 2940 9102229 SGTC_599 1935-0052 86.5 µM -0.196036084989558 0.432448912691564 no 1926 0.422290961096628 2759 9557311 SGTC_1073 triclabendazole 3.09 µM -0.196117774001444 0.432418670624917 no 1927 0.422258992377906 2831 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2281 7943571 200 µM -0.198230489298436 0.431636660908954 no 1928 0.421432366887943 2897 1244024 SGTC_2279 7948423 32.93 µM -0.1985676071888 0.431511903313145 no 1929 0.421300497352853 2903 1247112 SGTC_807 1315-0151 48 µM -0.199045612826174 0.431335018944357 no 1930 0.421113532256362 2949 4011080 SGTC_2110 5483698 200 µM -0.199263783226273 0.431254290300428 no 1931 0.421028203921581 2814 2848765 YHR062C RPP1 SGTC_2163 5671233 125 µM -0.1992882335515 0.431245243231854 no 1932 0.421018641418508 2911 701023 SGTC_3165 9101544 49.47 µM -0.202242801252053 0.430152265934329 no 1933 0.419863456923487 2868 5002184 SGTC_1006 4099-6547 255 µM -0.204160109485768 0.429443285639426 no 1934 0.419114191400538 2865 3146833 SGTC_3275 9138069 49.47 µM -0.204203926391683 0.429427085718919 no 1935 0.419097071594498 2845 17617007 SGTC_3006 9075424 71.4286 µM -0.204337921802174 0.429377545874986 no 1936 0.41904471888412 2792 7465181 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.204442048035992 0.429339049821602 no 1937 0.41900403720758 2921 5377381 SGTC_1094 duloxetine 25.4 µM -0.206328849238604 0.428641605585288 no 1938 0.418267022445274 2761 60834 A selective serotonin reuptake inhibitor. SGTC_1696 st025591 34.7925 µM -0.207048172419773 0.428375770819527 no 1939 0.417986118685249 2788 2787147 SGTC_2916 7875993 68.79 µM -0.207918038041642 0.428054344656393 no 1940 0.417646482310509 2782 1299250 SGTC_1771 st048882 4.1505 µM -0.212119820190669 0.426502409771814 no 1941 0.416006778626855 2768 4580403 SGTC_42 0133-0086 60.653 µM -0.212189289969969 0.426476760490203 no 1942 0.415979680935978 2736 162923 Model of phenazepam hydroxylation. SGTC_3021 9087658 49.47 µM -0.213504478393742 0.425991232039461 no 1943 0.415466748197589 2800 25237042 SGTC_161 4065-0411 162.148 µM -0.214331357839894 0.425686030124446 no 1944 0.415144333075694 2912 1906281 YLR208W SEC13 SGTC_157 1348-1695 65.819 µM -0.214361554260428 0.425674885441081 no 1945 0.415132560029979 2784 5380510 SGTC_2655 perillic acid 100 µM -0.214600727032843 0.425586615327985 no 1946 0.415039313525478 2786 5702197 An apoptosis inducer. SGTC_935 2996-0153 430 µM -0.215873114896158 0.425117085288855 no 1947 0.414543327100279 2952 23738523 SGTC_1701 st028638 40.4 µM -0.216985332566389 0.42470674739513 no 1948 0.414109887777679 2899 3490878 SGTC_2851 9015922 71.43 µM -0.217178631510759 0.424635440633155 no 1949 0.414034568425943 2983 2996893 SGTC_1312 1218-2183 165 µM -0.217472621608969 0.424526994268039 no 1950 0.413920020610654 2773 6744073 SGTC_2303 7774051 200 µM -0.217830304456004 0.424395060778253 no 1951 0.413780665967472 2966 2953184 SGTC_681 1642-0006 26.6 µM -0.218326252967136 0.424212141177462 no 1952 0.413587460445628 2800 4446530 SGTC_2468 5987765 72.9 µM -0.218364312618959 0.424198104393566 no 1953 0.413572634498216 2844 26772094 SGTC_691 1548-0686 185 µM -0.221198990933908 0.42315291787861 no 1954 0.412468747459608 2820 46495133 SGTC_71 0417-1750 47.813 µM -0.22246366686488 0.422686787694708 no 1955 0.411976477127311 3016 6811472 SGTC_3349 9149703 23.001 µM -0.222555865110601 0.42265280978717 no 1956 0.411940594714846 2763 4910494 SGTC_296 1222-0039 74.9 µM -0.222694563407975 0.422601696255292 no 1957 0.411886616446655 2834 5984176 SGTC_1768 st044301 37.178 µM -0.223445792885611 0.422324873475966 no 1958 0.411594283769196 2842 3931349 SGTC_1956 st077085 54 µM -0.223517964047167 0.422298280928209 no 1959 0.41156620173742 2840 24208685 SGTC_1843 st055809 45.5 µM -0.223821425828035 0.422186469757217 no 1960 0.411448128738092 2932 16413835 SGTC_2966 9084041 48.03 µM -0.22408434958475 0.422089599981771 no 1961 0.411345835036011 2753 17741380 SGTC_130 0136-0219 337.655 µM -0.224658541349055 0.421878065209281 no 1962 0.411122459671422 2770 234244 SGTC_2231 micatex 6.853 µM -0.22599970642085 0.421384061999205 no 1963 0.410600824331952 2830 20737 An antifungal of unknown mechanism. SGTC_823 0417-1665 178 µM -0.22796836334492 0.4206591534521 no 1964 0.409835417681066 2905 3429856 SGTC_757 1066-0008 322 µM -0.229896331254829 0.419949488272321 no 1965 0.409086163609022 2972 6842497 SGTC_2871 9038510 12.99 µM -0.230806533809237 0.419614542342752 no 1966 0.408732552514962 2960 4945164 SGTC_38 0929-0051 58.268 µM -0.231391298554093 0.419399385155475 no 1967 0.40850541225327 2949 1379719 SGTC_361 000s-0510 1.45 µM -0.232576991488578 0.418963197664629 no 1968 0.408044947769615 2902 660 SGTC_972 1319-0219 195 µM -0.233316134776148 0.418691335248791 no 1969 0.407757965283287 2903 23903702 SGTC_944 3370-0224 231 µM -0.233392051306384 0.418663414779197 no 1970 0.407728492452445 2855 4580514 SGTC_1489 4065-0444 182 µM -0.23430683424468 0.418327009513059 no 1971 0.407373390313256 2917 2877968 SGTC_362 0310-0100 9.03 µM -0.234554021795228 0.418236118196614 no 1972 0.407277449639949 2954 790235 SGTC_1545 lovastatin 49.4 µM -0.236226271795236 0.417621343716316 no 1973 0.406628547188072 2881 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1156 4092-0367 4.88 µM -0.23931837811346 0.416485114300562 no 1974 0.405429357862169 2859 1357585 SGTC_2373 9071805 200 µM -0.239696630257584 0.416346168963578 no 1975 0.405282723734023 2963 10149009 SGTC_3276 9139060 49.47 µM -0.240717692520249 0.415971149066147 no 1976 0.404886962737855 2808 4870619 SGTC_181 1447-1644 8.07 µM -0.241852534259292 0.415554429555596 no 1977 0.404447215260739 2928 534600 SGTC_866 0495-0101 262 µM -0.242321789347812 0.415382144484478 no 1978 0.404265415679095 2826 635694 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.244052446916312 0.414746881572341 no 1979 0.403595100462125 3020 688751 SGTC_462 ag-879 158 µM -0.244624503491523 0.414536948857288 no 1980 0.403373594677919 2954 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2964 9083345 53.42 µM -0.2447287668053 0.414498689045141 no 1981 0.403333226261756 2884 17741579 SGTC_715 0868-0130 184 µM -0.245506048331503 0.41421348827732 no 1982 0.403032312782012 3005 2876258 SGTC_2156 5649887 115 µM -0.245606681305138 0.414176567248882 no 1983 0.402993358353004 2950 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_537 1334-0398 209 µM -0.247276053794828 0.413564205434757 no 1984 0.402347294873765 3012 5846986 SGTC_692 k241-0027 77.8 µM -0.248232565369785 0.413213430981972 no 1985 0.401977235588877 3012 3600480 SGTC_2065 5221596 34.26 µM -0.248599852293573 0.413078756940572 no 1986 0.401835161381764 2969 788581 SGTC_403 arphamenine a 50 µM -0.249907074659825 0.412599517441556 no 1987 0.401329606000682 2845 5487158 An arginine aminopeptidase inhibitor. SGTC_844 0330-0132 15.3 µM -0.250273450983002 0.412465223919434 no 1988 0.401187943155836 2972 2828079 SGTC_1141 3253-0389 52.6 µM -0.252025075687217 0.411823315971948 no 1989 0.400510840828696 2923 5402031 SGTC_1913 st060213 96.1 µM -0.252049782441657 0.411814263511204 no 1990 0.400501292399114 3029 688959 SGTC_2056 5235370 200 µM -0.252071282330404 0.41180638607203 no 1991 0.400492983376624 2883 5511916 SGTC_2161 5662504 8.5105 µM -0.252225396601167 0.411749920504573 no 1992 0.400433424436145 2873 2859334 SGTC_1107 amlodipine 47 µM -0.252630789575766 0.411601398248883 no 1993 0.400276767484458 2912 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1829 berberine 14.4 µM -0.252664134561627 0.411589182338864 no 1994 0.400263882617628 3013 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_74 000s-0487 160.283 µM -0.252782712711617 0.411545742018808 no 1995 0.400218063604508 2812 677548 SGTC_1555 citronellol 128 µM -0.253629176464333 0.411235677154142 no 1996 0.399891026970854 2930 8842 A terpine precursor. SGTC_713 1488-1073 324 µM -0.254351400386251 0.410971165924215 no 1997 0.399612046677796 2832 3312542 SGTC_2563 tomatine 8.54 µM -0.256693137393576 0.410113794357398 no 1998 0.398707834826176 2956 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_87 0100-0052 35.5 µM -0.258092993561175 0.409601475009542 no 1999 0.3981675693894 2918 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2717 st081029 62.2815 µM -0.259610762079639 0.409046176485851 no 2000 0.39758201698359 2978 5292846 SGTC_2456 5770359 74.46 µM -0.260067290701486 0.408879184247908 no 2001 0.397405934120824 3014 3118787 SGTC_1527 coumarin 137 µM -0.260356241454628 0.408773498361793 no 2002 0.397294496759501 3062 323 A hepatotoxic, DNA x-linker. SGTC_3219 9131112 49.47 µM -0.260918086507619 0.4085680183509 no 2003 0.397077838408309 2943 17612988 YMR079W SEC14 SGTC_99 0109-0120 622.8 µM -0.261271695555699 0.408438708049937 no 2004 0.396941496179971 3048 759414 SGTC_1705 st027868 56.3335 µM -0.261996385044993 0.408173729547505 no 2005 0.396662114595583 2945 292948 SGTC_2133 5320837 200 µM -0.262002856167054 0.408171363608267 no 2006 0.396659620093645 3026 2841355 SGTC_3031 9088762 49.47 µM -0.262709343900124 0.407913081254509 no 2007 0.396387307152239 2821 205253 SGTC_2575 plumbagin 510 nM -0.262729847726196 0.407905585930142 no 2008 0.396379404786461 2827 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2933 9026794 32.47 µM -0.263424599395719 0.407651634286059 no 2009 0.396111666192999 2925 17586027 SGTC_1261 0712-0010 12.7 µM -0.263640731069473 0.407572639873623 no 2010 0.396028384849638 3034 2840123 SGTC_129 0088-0017 176.636 µM -0.264102445318765 0.407403899570957 no 2011 0.395850489840013 2979 182446 SGTC_1975 st070967 30.8 µM -0.264313839616276 0.407326648129638 no 2012 0.39576904845233 3013 261391 SGTC_2413 inermin 26.06 µM -0.264329630938693 0.407320877530078 no 2013 0.395762964898408 3166 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2960 9079389 5.97 µM -0.266609298168911 0.406488033760057 no 2014 0.394884997898983 3039 16457355 SGTC_1940 st075990 51.1 µM -0.266702590314661 0.4064539597917 no 2015 0.394849079678837 3132 1084979 SGTC_2102 5377816 72.7585 µM -0.266920531192945 0.406374361954384 no 2016 0.394765174185516 3066 1379702 SGTC_3149 9097855 49.47 µM -0.266992720054392 0.406347997504411 no 2017 0.394737383127717 3033 25236625 YMR079W SEC14 SGTC_2793 7325131 81.82 µM -0.269137088718758 0.405565036185834 no 2018 0.39391209518117 2944 4176441 SGTC_1587 estradiol valerate 56.1 µM -0.269444883405199 0.405452683760056 no 2019 0.393793675420772 3041 13791 A steroid. SGTC_661 1304-0007 33.6 µM -0.273310851626667 0.404042179137377 no 2020 0.39230713719683 2904 3117130 SGTC_2600 tangeritin 87.95 µM -0.273407697880613 0.404006860559142 no 2021 0.392269918042501 2864 68077 A bioactive flavone. SGTC_3123 9126162 49.47 µM -0.274698012653462 0.403536374197472 no 2022 0.39177412906062 2869 25239884 SGTC_666 0272-0154 136 µM -0.275602722258721 0.40320657390738 no 2023 0.391426609279678 2929 6870312 SGTC_1190 1486-1332 13 µM -0.278124890919391 0.402287513797114 no 2024 0.390458244525559 2934 4150046 SGTC_3159 9100096 49.47 µM -0.278421130491677 0.402179601562215 no 2025 0.390344550367176 2798 25236875 SGTC_1923 st058458 19.1 µM -0.278974560260236 0.401978021726563 no 2026 0.390132173989166 3143 3534982 SGTC_3302 9125395 16.351 µM -0.279187209857041 0.401900573714895 no 2027 0.390050579304536 2939 17599668 SGTC_2905 7799065 20.05 µM -0.279235764021994 0.40188289059326 no 2028 0.390031949514443 3076 1296806 SGTC_98 0074-0023 107.663 µM -0.279383609809597 0.401829047323988 no 2029 0.389975223990326 2973 3563821 SGTC_355 1311-2252 105 µM -0.279949695829976 0.401622904325273 no 2030 0.389758049576239 2908 5338538 SGTC_3260 9137109 49.47 µM -0.280423507849114 0.401450384397135 no 2031 0.38957630180543 2988 17478346 SGTC_627 1391-0720 175 µM -0.280524044292177 0.40141378049239 no 2032 0.3895377405134 2980 997839 SGTC_3259 9138485 49.47 µM -0.280784587834801 0.401318924280211 no 2033 0.389437812702026 3198 17646153 SGTC_303 1348-1668 34.2 µM -0.281023537629668 0.401231934826457 no 2034 0.389346173295179 2920 5380509 SGTC_947 3447-0010 211 µM -0.281050805628557 0.401222008247592 no 2035 0.389335716162134 2879 748350 SGTC_2841 9004761 38.96 µM -0.281650408786087 0.401003746235774 no 2036 0.389105791798014 2921 2991039 SGTC_1713 st033146 12.748 µM -0.281843820575363 0.400933348846758 no 2037 0.38903163421819 3050 674619 SGTC_2597 laccaic acid a 100 µM -0.282278087072796 0.400775297673468 no 2038 0.388865143316444 3045 5491415 A textile dye. SGTC_3194 9111903 49.47 µM -0.283254504309425 0.400419990236323 no 2039 0.388490874974164 3111 17087251 SGTC_293 4049-0273 38.5 µM -0.283837909851627 0.400207734711295 no 2040 0.388267300453292 2951 1380311 SGTC_3161 9100388 49.47 µM -0.284230845003928 0.400064793030459 no 2041 0.388116739457688 2909 25236368 SGTC_2001 4023502 57.655 µM -0.284652309061689 0.3999114880057 no 2042 0.387955265729413 3027 108941 YCR052W RSC6 SGTC_1992 st073643 23.3 µM -0.285156247493219 0.39972820367201 no 2043 0.387762219375819 2872 3161292 SGTC_1189 1431-2119 7.28 µM -0.286857473413104 0.39910962469877 no 2044 0.387110726935201 2920 3107275 SGTC_1228 0124-0032 52.5 µM -0.287118600000178 0.399014699423277 no 2045 0.387010755380226 2995 X1228 SGTC_693 4161-2696 114 µM -0.287278535139741 0.398956562420117 no 2046 0.386949528377543 3017 805759 SGTC_2900 5328528 85.29 µM -0.287325514694759 0.398939485607376 no 2047 0.386931544012937 2905 795359 SGTC_1795 st049545 62.3 µM -0.287722508524475 0.398795188236297 no 2048 0.386779579478062 3024 5291882 SGTC_2032 5185112 25.99 µM -0.289941455827971 0.397988911394778 no 2049 0.38593051299004 2977 5718189 SGTC_2225 6654152 15.4 µM -0.290787120474931 0.397681745043026 no 2050 0.385607068142645 2970 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2834 9001755 58.44 µM -0.29127788991996 0.397503514492971 no 2051 0.385419397982708 2973 2989575 SGTC_477 mead ethanolamide 10 µM -0.292788770994258 0.396954949032474 no 2052 0.384841805889004 2886 16061185 SGTC_714 4296-0578 26.1 µM -0.293744018446168 0.396608226202319 no 2053 0.384476757739339 2916 1589775 SGTC_2775 cyproheptadine 69.59 µM -0.294760062608833 0.396239525910623 no 2054 0.384088588514818 3010 2913 A selective serotonin reuptake inhibitor. SGTC_3191 9110352 49.47 µM -0.294849864643602 0.39620694316664 no 2055 0.384054286156167 2933 17122424 SGTC_1674 st016616 23.6 µM -0.297054937526054 0.395407107726537 no 2056 0.383212283464754 2876 625830 SGTC_2926 9010726 65.15 µM -0.298405317967547 0.394917507948243 no 2057 0.382696915354095 3051 2994293 SGTC_997 3996-0078 137 µM -0.298819805142791 0.394767262920975 no 2058 0.382538769337312 3002 735687 SGTC_1729 st035615 45.989 µM -0.299198082207349 0.3946301571421 no 2059 0.382394456245312 3036 17385451 SGTC_60 0986-0278 202 µM -0.300419490875398 0.394187549150229 no 2060 0.381928599173814 2925 3110598 SGTC_1234 0326-0494 15.5 µM -0.301727657440548 0.393713653778787 no 2061 0.381429841367059 3076 1547813 SGTC_427 1354-0053 47.3 µM -0.301867546376708 0.393662987026747 no 2062 0.381376518281388 3154 6813657 SGTC_1539 benzyladenosine 56 µM -0.302294501134101 0.393508358264609 no 2063 0.381213784920199 2926 92208 A nucleotide analog. SGTC_3264 9137442 49.47 µM -0.303398259965187 0.393108691538178 no 2064 0.380793185784453 3175 17015726 SGTC_1298 1079-1278 263 µM -0.30463445563882 0.392661203688001 no 2065 0.380322287377816 2960 2840950 SGTC_3187 9109394 49.47 µM -0.30498717136996 0.392533550853814 no 2066 0.380187961457989 2981 17098090 SGTC_849 0386-0493 241 µM -0.305303355984293 0.392419128976052 no 2067 0.38006756008786 2930 726119 SGTC_1203 3992-3522 103 µM -0.306002093270886 0.392166300736241 no 2068 0.379801525991035 3281 5322312 SGTC_731 3966-0296 387 µM -0.306329575123417 0.392047821702135 no 2069 0.379676861588743 2949 660956 SGTC_1040 k898-0338 155 µM -0.306335334315893 0.392045738184408 no 2070 0.379674669315644 3153 20969351 SGTC_1929 genistein trimethyl ether 50.5 µM -0.307013351499188 0.391800471830349 no 2071 0.379416604828243 3139 136420 SGTC_1424 4048-1941 275 µM -0.307227237386585 0.39172310953393 no 2072 0.379335207482591 3074 X1424 SGTC_2549 cedrol 20.94 µM -0.307965440668106 0.391456135104776 no 2073 0.379054314731369 3111 6708665 A sedative which affects the nervous system. SGTC_2141 5621638 7.665 µM -0.308195454743175 0.391372959953723 no 2074 0.378966805421459 3067 2856238 SGTC_2232 chlorophetanol 41.5365 µM -0.309143075166542 0.391030344335796 no 2075 0.378606346824872 3021 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_233 rapamycin 362 pM -0.309482880608605 0.390907507022212 no 2076 0.378477116351196 2972 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_950 1165-0508 94.1 µM -0.309516378071087 0.390895398510693 no 2077 0.378464377758946 3032 6148369 SGTC_270 tamoxifen 5.46 µM -0.310110240081817 0.390680749522608 no 2078 0.378238562709831 3150 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_466 geldanamycin 89.2 µM -0.310222170258809 0.390640296547808 no 2079 0.378196006099981 3004 5288382 HSP90 inhibitor. SGTC_2282 7944268 200 µM -0.311887009698879 0.390038742577512 no 2080 0.377563197599883 3151 2970414 SGTC_840 0245-0196 390 µM -0.312870704934043 0.389683429059608 no 2081 0.377189447540392 3094 3827528 SGTC_1158 4092-0494 91.8 µM -0.31310288687506 0.389599577717386 no 2082 0.377101247943695 3101 1148199 SGTC_1289 0976-0073 69.1 µM -0.316241549293916 0.388466571331105 no 2083 0.375909586478658 3070 3391136 SGTC_2650 prasterone 100 µM -0.316618695561696 0.388330491260075 no 2084 0.375766474049296 2984 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2372 9071633 200 µM -0.316878758482331 0.388236664612864 no 2085 0.375667800177257 3099 21321366 SGTC_1463 k081-0032 34.1 µM -0.319099928101328 0.387435567522019 no 2086 0.374825369090858 3033 977755 SGTC_550 4123-0385 25.7 µM -0.31948488463735 0.387296775967958 no 2087 0.374679425807609 2965 5731123 SGTC_3051 9093778 49.47 µM -0.320008124489217 0.387108151089002 no 2088 0.37448108585126 3014 17217378 SGTC_395 anisomycin 6.25 µM -0.322421721117931 0.386238409453888 no 2089 0.373566615518053 3021 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1579 chlormadinone acetate 49.4 µM -0.32419398147164 0.385600137411699 no 2090 0.372895589163257 3120 45114258 A steroidal progestin. SGTC_329 k048-0121 21.3 µM -0.324584866370199 0.385459403496076 no 2091 0.372747641238591 3045 6832902 SGTC_2090 5301565 104.445 µM -0.324906755266648 0.385343522172529 no 2092 0.372625822037652 2987 2056344 SGTC_204 PMA1.184 62.41 µM -0.326207067489657 0.384875508730507 no 2093 0.37213384726568 2986 2252213 YGL008C PMA1 SGTC_822 1487-0950 154 µM -0.327418427059363 0.384439662326122 no 2094 0.371675715543658 3144 1958375 SGTC_2779 methotrexate 400 µM -0.327764927319671 0.384315018591111 no 2095 0.371544703811359 3074 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_3008 9078912 71.4286 µM -0.328329105553855 0.384112096918127 no 2096 0.371331419887895 3012 16648731 SGTC_1259 0671-0132 43 µM -0.328378429260504 0.384094357847236 no 2097 0.371312775257336 3007 X1259 SGTC_633 0437-0093 97.7 µM -0.328611349958367 0.384010592144827 no 2098 0.371224734041936 2991 2831118 SGTC_2247 cerulenin 830 nM -0.329522842760708 0.383682842421785 no 2099 0.37088026557392 3215 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2745 rifampicin 24.3 µM -0.332480860712748 0.382619788313739 no 2100 0.369763094724197 3037 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_555 4296-0685 37 µM -0.333820526685806 0.382138628712157 no 2101 0.369257496517476 3038 2908540 YHR072W ERG7 SGTC_3224 9130643 49.47 µM -0.334076488597744 0.382046717126137 no 2102 0.369160920609197 3180 17644395 SGTC_583 1488-1091 88.9 µM -0.334668158871821 0.381834283804567 no 2103 0.368937711612238 3081 4303273 SGTC_976 1348-1067 47.6 µM -0.335105175288532 0.381677400251349 no 2104 0.368772874517583 3003 5310671 YGL099W LSG1 SGTC_3248 9135562 49.47 µM -0.335436752483156 0.381558381055216 no 2105 0.368647823874457 3045 17650701 SGTC_3272 9137413 49.47 µM -0.336370367422069 0.381223321393803 no 2106 0.368295796156733 2959 17614870 SGTC_1765 st044815 90.4 µM -0.336610776794677 0.381137056667927 no 2107 0.368205165575115 3081 645695 SGTC_1329 1447-1697 50.6 µM -0.336882230049781 0.381039659742281 no 2108 0.368102840750118 3089 2840515 SGTC_2722 naftopidil 47.16 µM -0.337095760350961 0.380963050760486 no 2109 0.368022356668405 3112 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2903 5923464 63.88 µM -0.337650851718285 0.380763920607345 no 2110 0.367813158117022 3093 2876576 SGTC_3232 9132874 49.47 µM -0.3382963498736 0.380532398182165 no 2111 0.367569937060723 3013 3784940 SGTC_3005 9076496 71.4286 µM -0.338342265339571 0.380515931196964 no 2112 0.367552638323614 3103 21368410 SGTC_2168 5727979 200 µM -0.339914784858813 0.37995209836838 no 2113 0.366960351096171 2989 695210 SGTC_2030 5175110 200 µM -0.339937834506287 0.379943835723941 no 2114 0.3669516718299 3130 2831986 SGTC_900 1112-0045 141 µM -0.340758694312886 0.379649616534911 no 2115 0.366642624230939 3043 56211 YIL048W NEO1 SGTC_440 fluspirilene 35.1 µM -0.34125197830976 0.379472843208326 no 2116 0.366456948047937 3226 3396 An atypical antipsychotic. SGTC_1603 st002045 67.8 µM -0.341370693654614 0.379430304119256 no 2117 0.366412267272931 3136 5887985 SGTC_2200 6600604 21.907 µM -0.341398871110998 0.379420207548451 no 2118 0.366401662417867 2999 2904777 SGTC_2787 5284540 71.43 µM -0.341688793949373 0.379316326920626 no 2119 0.366292553112429 3051 736958 SGTC_2593 nobiletin 86.24 µM -0.342558847054324 0.379004635401872 no 2120 0.365965183012607 3067 72344 An anti-infammatory. SGTC_20 0481-0013 4.944 µM -0.343123226034408 0.378802491926628 no 2121 0.365752879387649 3043 182045 SGTC_2028 5153890 36.43 µM -0.343198561186308 0.378775511661029 no 2122 0.365724543514122 3010 2830968 YPR165W RHO1 SGTC_136 0097-0015 404.482 µM -0.343426249864203 0.378693971632289 no 2123 0.365638907235499 3077 4861337 SGTC_911 3456-4043 236 µM -0.344307169531007 0.378378546953291 no 2124 0.365307646522158 3084 914281 SGTC_1993 st073995 70.8 µM -0.344325008963171 0.378372160150238 no 2125 0.365300939225553 3022 3098394 SGTC_1090 efavirenz 20.7 µM -0.344843199157114 0.378186654251091 no 2126 0.365106127282391 3057 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2405 ticlatone 3.52 µM -0.344869706917545 0.378177165544042 no 2127 0.365096162710248 2838 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1126 isoteolin 1.0172 µM -0.345093908417602 0.378096913406458 no 2128 0.365011886430831 2993 133323 SGTC_1482 3346-2049 8.48 µM -0.34519307239055 0.378061419688873 no 2129 0.364974613243705 3096 3826804 SGTC_1826 st055655 41.6 µM -0.346081368352505 0.377743518237899 no 2130 0.364640782579256 3086 676168 SGTC_404 fumagillin 50 µM -0.346224787150785 0.377692199583201 no 2131 0.36458689394983 3085 12015870 A methionine aminopeptidase binder. SGTC_3321 9137793 26.8275 µM -0.346922351570057 0.377442625256259 no 2132 0.364324827080859 3077 4904192 SGTC_291 SEC14.278 35.5 µM -0.346973455736618 0.37742434323787 no 2133 0.364305630329319 3143 1068044 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.347251994799316 0.377324703427461 no 2134 0.364201005996439 3124 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3319 9138450 16.7555 µM -0.348267136741806 0.376961633032162 no 2135 0.363819785934883 3012 2029690 SGTC_2442 5158906 48.48 µM -0.350697115619311 0.376092981743275 no 2136 0.362907794848371 3152 1893835 SGTC_2190 6049624 200 µM -0.350766175861834 0.376068303734714 no 2137 0.3628818873011 3107 2265554 SGTC_2963 9082507 9 µM -0.352445860083162 0.375468241130095 no 2138 0.362251957076235 3190 16459611 SGTC_3285 9112818 20.8695 µM -0.353437399462965 0.375114157654043 no 2139 0.361880275987408 3018 17017947 YPR165W RHO1 SGTC_1221 2958-7315 257 µM -0.356740663121749 0.373935306992978 no 2140 0.360642980515397 3120 4562705 SGTC_2521 angolensin 13.4 µM -0.357197468150103 0.373772377394139 no 2141 0.360471990584974 3184 821428 A flavenoid. SGTC_2182 6325192 200 µM -0.35733392731011 0.373723710595716 no 2142 0.360420916999129 3103 736248 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.357699751209045 0.373593253086277 no 2143 0.360284009654025 3084 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_3257 9139206 32.98 µM -0.358240199281031 0.373400548857879 no 2144 0.360081783071785 3150 4910041 SGTC_1708 st033234 31.827 µM -0.359569466144814 0.372926715160397 no 2145 0.359584560427518 3150 674664 SGTC_1227 3909-8010 46.6 µM -0.360579990685835 0.372566629661027 no 2146 0.359206724764446 3039 15982272 SGTC_295 k015-0027 31 µM -0.360748754846833 0.372506503886911 no 2147 0.359143637159566 3108 3887424 SGTC_1379 2144-0755 36.5 µM -0.361003530376478 0.372415740643772 no 2148 0.359048403966196 3221 5392327 SGTC_3312 9133330 71.43 µM -0.361604133113512 0.372201805238376 no 2149 0.358823937811547 3185 17617324 SGTC_1502 4534-4282 27.7 µM -0.362527538825844 0.371872963980977 no 2150 0.35847892405255 3089 3278949 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.362755152145745 0.37179192116173 no 2151 0.358393898203561 2954 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1926 methyl fluorone black 53.6 µM -0.363036679355071 0.371691689901464 no 2152 0.358288742321283 3061 72721 Reacts with homocysteine. SGTC_1524 corynanthine 62.1 µM -0.364735569259261 0.371087024214409 no 2153 0.357654402297402 3207 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_3292 9120825 59.784 µM -0.3650955907506 0.370958926845647 no 2154 0.357520026074477 3215 24824900 SGTC_1439 4092-1168 46 µM -0.365423474676846 0.370842276616615 no 2155 0.357397660403832 3112 2886240 SGTC_903 1134-0042 114 µM -0.365684015808315 0.370749593183562 no 2156 0.357300437391381 3059 701009 SGTC_1062 mesoridazine 14.2 µM -0.366090276576811 0.370605087234321 no 2157 0.357148856412029 3042 4078 A neuroleptic. SGTC_1772 st048439 82.2 µM -0.36644562686897 0.370478704980052 no 2158 0.357016289250369 3138 2927068 YDL195W SEC31 SGTC_1488 4013-0813 75.9 µM -0.366677610417138 0.370396206316048 no 2159 0.356929754661026 3058 2910057 SGTC_2206 7254556 146.969 µM -0.366749021733048 0.37037081201588 no 2160 0.356903118266885 3093 4398905 SGTC_1436 4092-1007 8.32 µM -0.368210460369765 0.369851239734463 no 2161 0.356358155591416 3069 2881121 SGTC_1365 1672-3266 55.4 µM -0.368888474806618 0.36961027188135 no 2162 0.356105427120169 3147 6415873 SGTC_2956 9076196 2.52 µM -0.368985278117188 0.369575871942314 no 2163 0.356069349041173 3188 16423868 SGTC_1340 1486-1359 257 µM -0.370924640920119 0.368886921987311 no 2164 0.355346830746147 3068 4309068 SGTC_379 3970-0972 5.9 µM -0.371279659656805 0.368760848703109 no 2165 0.355214623118072 3106 2898042 YBL034C STU1 SGTC_782 0083-0095 30.5 µM -0.372748762160732 0.368239295304784 no 2166 0.354667720337531 3018 3591729 An indicator and reagent. SGTC_2253 7938677 135.83 µM -0.372948388420263 0.368168443703099 no 2167 0.354593428554687 3233 2301972 SGTC_266 formosanin C 406 nM -0.373896003673021 0.367832176108622 no 2168 0.354240844892122 3156 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1520 flindersine 88 µM -0.374650861864077 0.367564382097738 no 2169 0.353960070618351 3312 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_323 4013-0906 34.3 µM -0.375297665823263 0.367334972692677 no 2170 0.353719550953817 3152 2910086 SGTC_2534 helenine 20.12 µM -0.3756987445652 0.367192741254976 no 2171 0.35357043566131 3024 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2228 7354201 200 µM -0.376436617274847 0.366931122802156 no 2172 0.35329616393233 3085 753451 SGTC_1079 idarubicin 2.36 µM -0.377811985661683 0.366443640350945 no 2173 0.352785134635084 3187 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2354 9060492 162 µM -0.378466926841679 0.36621158014558 no 2174 0.352541879177394 3223 6471895 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.381372811103472 0.36518255193327 no 2175 0.351463316447311 3211 5282362 SGTC_2112 5488546 200 µM -0.381413147214337 0.365168274967308 no 2176 0.351448353480286 3051 600757 SGTC_2727 riluzole 51.77 µM -0.382397954333609 0.364819760523964 no 2177 0.351083103750282 3117 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1022 4477-0945 21.3 µM -0.384003521504039 0.364251804185931 no 2178 0.350487918725787 3066 4648966 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.384752626599566 0.363986916210725 no 2179 0.350210350299754 3139 229346 A bile salt which induces apoptosis. SGTC_2355 9061122 103.12 µM -0.386615657615019 0.363328419448034 no 2180 0.349520382290209 3180 5302957 SGTC_917 harmaline 728.087 nM -0.386724962446706 0.363289797678169 no 2181 0.349479916978667 3168 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1805 st050013 60.3 µM -0.387213776879611 0.363117096993932 no 2182 0.349298975845645 3110 4037144 SGTC_879 0831-1030 162 µM -0.38851568273115 0.362657262721041 no 2183 0.348817225323092 3105 1549252 SGTC_636 0kpi-0074 126 µM -0.388639374628284 0.362613584926112 no 2184 0.348771467673065 3139 616434 SGTC_3167 9103034 49.47 µM -0.389009370736315 0.362482943435685 no 2185 0.34863460722871 3141 5127859 SGTC_3065 9113888 49.47 µM -0.389662044258783 0.362252530749985 no 2186 0.348393233290014 3272 16648368 SGTC_1895 st058434 18.3 µM -0.389715253427488 0.362233748568682 no 2187 0.348373557999285 3230 5393175 SGTC_1418 3966-3099 2.4 µM -0.389919718593321 0.362161577969413 no 2188 0.348297956187231 3173 740335 SGTC_2831 7999036 19.48 µM -0.390051245700112 0.362115155095393 no 2189 0.348249326699337 3294 2988270 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.390983939843392 0.361786016213033 no 2190 0.34790455351389 3039 688667 SGTC_889 0919-1524 82.7 µM -0.392509823957479 0.36124776673178 no 2191 0.347340777044017 3156 3905452 SGTC_2736 butenafine 14.65 µM -0.392843167464725 0.361130217656099 no 2192 0.347217659744035 3103 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1493 4348-0038 111 µM -0.393608007476538 0.360860556752986 no 2193 0.346935234203663 3187 800424 SGTC_2697 mebhydrolin 72.4 µM -0.393681852191166 0.360834524858927 no 2194 0.346907970732908 3267 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_3083 9117465 49.47 µM -0.395410630883823 0.360225276620047 no 2195 0.346269932330445 3183 16420915 SGTC_309 k408-0051 1.48 µM -0.397470723279711 0.359499731712671 no 2196 0.345510185829932 3157 3640463 SGTC_2316 5844804 197.44 µM -0.397844625543076 0.359368101099299 no 2197 0.345372360096733 3193 776813 SGTC_3023 9089636 49.47 µM -0.399094493933239 0.358928211749915 no 2198 0.344911789589611 3219 17249241 SGTC_2285 7945142 200 µM -0.399193555696715 0.358893355098315 no 2199 0.34487529562042 3210 2970608 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.399414383696576 0.358815657049969 no 2200 0.344793948636933 3144 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2417 cerulenin 830 nM -0.3995828510969 0.358756385939397 no 2201 0.344731894687779 3224 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.399968755945757 0.358620627632226 no 2202 0.344589764713814 3117 689007 SGTC_3145 9085516 49.47 µM -0.401181373500322 0.358194154581708 no 2203 0.344143296684689 3194 25236195 SGTC_592 k241-0073 46.5 µM -0.401375860326475 0.358125770737843 no 2204 0.344071709674886 3244 4230158 SGTC_1804 st050076 49.1 µM -0.405202670010124 0.356781147998515 no 2205 0.342664271273591 3220 3895976 SGTC_1753 st043925 64 µM -0.405395591800724 0.356713408167958 no 2206 0.342593375370364 3207 670181 SGTC_3291 9121177 71.43 µM -0.405505266342041 0.356674900614254 no 2207 0.34255307407119 3133 17015612 SGTC_2338 7999974 200 µM -0.406820376211742 0.356213269552042 no 2208 0.342069960008625 3136 315925 SGTC_788 1182-0090 188 µM -0.407100361866666 0.356115015908309 no 2209 0.341967138818383 3292 5715185 SGTC_2732 terfenadine 20 µM -0.408193622360487 0.355731456262187 no 2210 0.341565765011767 3146 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2564 betulinic acid 100 µM -0.408246924904314 0.355712759321192 no 2211 0.341546200376225 3369 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2817 7995342 71.43 µM -0.408648520985464 0.355571902568388 no 2212 0.34139880870107 3055 18879975 SGTC_2877 9040724 71.43 µM -0.410093204326797 0.355065354144754 no 2213 0.340868788787616 3287 6463895 SGTC_286 k060-0067 22.9 µM -0.410853313397641 0.354798940311118 no 2214 0.340590048846648 3151 5985051 SGTC_56 0957-0365 83.25 µM -0.410976601736316 0.354755735149479 no 2215 0.340544845924052 3235 6752360 SGTC_2265 7929201 200 µM -0.411915213932588 0.354426869207085 no 2216 0.340200784580364 3057 1265108 SGTC_2047 4141938 200 µM -0.412916532025942 0.354076152326841 no 2217 0.339833884147776 3156 3807862 SGTC_3018 9082602 49.47 µM -0.413300289260441 0.35394177214296 no 2218 0.339693308982053 3224 17332089 SGTC_1492 4158-0558 28.5 µM -0.413580636693567 0.353843614444019 no 2219 0.339590628235933 3214 3967268 SGTC_2626 ethyl orsellinate 100 µM -0.414130576423827 0.353651092952667 no 2220 0.339389240533967 3090 75653 A natural product. SGTC_650 1328-0195 38 µM -0.415724340775271 0.353093363567295 no 2221 0.338805863905967 3233 2780821 SGTC_1399 3562-5772 25 µM -0.415756225485636 0.353082208896481 no 2222 0.33879419686248 3099 23847490 SGTC_1270 0831-1170 17.3 µM -0.416369921367508 0.352867535757302 no 2223 0.338569667449898 3194 6764716 SGTC_2272 7805186 180 µM -0.41671293156338 0.352747569892654 no 2224 0.338444197253049 3263 2956062 YPR165W RHO1 SGTC_884 0851-0618 334 µM -0.417633332195984 0.352425737386518 no 2225 0.338107611224898 3231 9642473 SGTC_1933 st074711 15.9 µM -0.418285169634337 0.352197876086623 no 2226 0.337869315680226 3183 17250958 SGTC_3169 9102970 49.47 µM -0.419548638237742 0.351756359432919 no 2227 0.337407608074186 3235 17027839 SGTC_1117 retinoic acid 1.10837 µM -0.42013332287774 0.351552110124636 no 2228 0.337194030341157 3287 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1799 st045822 46.1415 µM -0.420445258902063 0.351443158279076 no 2229 0.337080105603318 3272 3674992 SGTC_1998 st075797 76.8 µM -0.422106289734369 0.35086320536803 no 2230 0.336473718597825 3256 24208315 SGTC_2480 5767542 37.17 µM -0.422861505836485 0.350599634613677 no 2231 0.336198154830656 3159 2867358 SGTC_2356 9061756 188.97 µM -0.424294773921826 0.350099621220032 no 2232 0.335675425046011 3195 20104043 SGTC_2380 9035439 200 µM -0.42472604181329 0.349949218854504 no 2233 0.335518198714033 3294 6462575 SGTC_213 1246-0773 967 nM -0.425091900265654 0.349821646133281 no 2234 0.335384841124711 3186 6251622 SGTC_2835 9006588 71.43 µM -0.426742998977244 0.349246128658135 no 2235 0.334783263987884 3323 2345538 SGTC_3353 9151644 39.2805 µM -0.427346803827631 0.34903574904834 no 2236 0.334563373677949 3269 4909158 SGTC_2120 5538279 151.968 µM -0.428230629292584 0.348727887429778 no 2237 0.334241609325639 3184 2058197 SGTC_776 4476-4378 112 µM -0.432165917639738 0.347358325531084 no 2238 0.332810414238626 3244 2892008 SGTC_682 0kpi-0099 17 µM -0.432479249262662 0.347249364956734 no 2239 0.332696565332638 3260 1714895 YML126C ERG13 SGTC_2763 lisinopril 49.32 µM -0.433850449588549 0.346772680831809 no 2240 0.332198521896056 3258 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1230 0170-0365 3.77 µM -0.43562082491841 0.346157586165653 no 2241 0.331555929458829 3332 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_926 2268-1401 59.4 µM -0.43621417571163 0.345951524560432 no 2242 0.331340671912241 3250 2931578 SGTC_909 3448-9333 149 µM -0.436737949440614 0.345769663900929 no 2243 0.331150702027718 3151 3344074 SGTC_557 1315-0110 16.2 µM -0.437309907906059 0.345571113551545 no 2244 0.330943305433459 3140 6833801 SGTC_1775 st081588 35.1725 µM -0.440092905655833 0.344605627408081 no 2245 0.329934909969548 3274 1426443 YGL099W LSG1 SGTC_148 3253-0744 288.01 µM -0.440494485080857 0.344466393591396 no 2246 0.329789502850336 3265 6893655 SGTC_1167 k781-0610 148 µM -0.440609658192736 0.344426465174306 no 2247 0.329747804785554 3198 4525169 SGTC_2293 7624732 200 µM -0.440939098417196 0.344312263830547 no 2248 0.329628543667153 3177 894453 SGTC_2294 7971431 200 µM -0.441520151776855 0.344110874713488 no 2249 0.329418237952084 3263 5741572 SGTC_2132 5317594 122.667 µM -0.441714099545405 0.344043663581946 no 2250 0.32934805274867 3134 794577 SGTC_988 1497-1057 103 µM -0.442563223271832 0.343749464208724 no 2251 0.329040845360101 3320 3533044 SGTC_894 0960-0238 55.9 µM -0.4427356915318 0.343689719977594 no 2252 0.328978461573339 3297 6741907 YDL195W SEC31 SGTC_1370 2001-0092 44.6 µM -0.443807160770232 0.34331864293117 no 2253 0.328591005394568 3392 790957 SGTC_2483 5729050 27.16 µM -0.446994014361622 0.342215848102022 no 2254 0.327439690839468 3357 2865180 SGTC_3243 9134147 49.47 µM -0.447445370587159 0.34205976698935 no 2255 0.327276761661053 3278 24282180 SGTC_2348 9022543 33.42 µM -0.447951041729551 0.34188493557228 no 2256 0.327094265131234 3280 3162678 YDL140C RPO21 SGTC_545 4218-0007 221 µM -0.449913141008516 0.341206878019124 no 2257 0.326386535908249 3299 2840508 SGTC_2419 paclitaxel 166.5 µM -0.450816460276235 0.340894883232785 no 2258 0.326060918444866 3207 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2336 9001819 198.65 µM -0.451175580391914 0.340770878000594 no 2259 0.325931504042898 3399 2989602 SGTC_3108 9121785 49.47 µM -0.45281428430941 0.340205247264125 no 2260 0.325341238456241 3275 17140271 SGTC_2826 7992541 19.48 µM -0.453086118109565 0.340111453225755 no 2261 0.325243365490224 3268 2985066 SGTC_474 dl-dihydrosphingosine 5 µM -0.453504979987195 0.339966947715998 no 2262 0.325092579092383 3330 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1876 myriocin 605 nM -0.454024281281994 0.339787823690332 no 2263 0.324905675201532 3340 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2314 7727897 200 µM -0.454729389697797 0.339544666607637 no 2264 0.324651967234794 3180 900724 SGTC_660 4031-1742 102 µM -0.454964970255763 0.339463441380444 no 2265 0.324567220144454 3244 6738706 SGTC_378 3970-0959 8.33 µM -0.455038950321876 0.339437935518193 no 2266 0.324540608636429 3293 6615653 SGTC_2342 7990637 118.86 µM -0.45505779460943 0.339431438753143 no 2267 0.32453383026564 3303 2033102 YER133W GLC7 SGTC_1802 st050112 57.9 µM -0.455596362515168 0.339245782018266 no 2268 0.324340129664614 3239 4662563 SGTC_872 0588-0139 234 µM -0.456820390990973 0.338823976448931 no 2269 0.323900074055534 3201 2047100 SGTC_3310 9130229 44.1445 µM -0.458369311267742 0.338290501361595 no 2270 0.323343567897994 3309 7761258 SGTC_1193 1488-0126 41.5 µM -0.459051367099544 0.33805569229506 no 2271 0.3230986396302 3218 1384710 SGTC_1335 1486-0900 202 µM -0.460495347107993 0.337558786083615 no 2272 0.322580355242235 3238 X1335 SGTC_2664 lyso-paf C-16 73.48 µM -0.460648494762665 0.337506101098404 no 2273 0.322525406502925 3203 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_244 nsc-207895 1.295 µM -0.460806157297409 0.337451866257098 no 2274 0.322468841892945 3188 42640 SGTC_2729 fluphenazine 10.66 µM -0.461407347329992 0.337245091962434 no 2275 0.32225319057923 3191 3372 An atypical antipsychotic. SGTC_231 b-estradiol 524 µM -0.461974075189129 0.33705021564863 no 2276 0.322049955868408 3197 450 A steroid. SGTC_2855 9016525 58.44 µM -0.464542096243564 0.336167718770788 no 2277 0.321129703369669 3231 43811474 SGTC_454 lyso-paf C-16 6.67 µM -0.466796098639464 0.335393877114898 no 2278 0.320322883684857 3260 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2103 5378138 10 µM -0.466931276869676 0.335347490020663 no 2279 0.320274523601654 3349 244142 SGTC_2139 5578692 56.4705 µM -0.469187056628737 0.334573778699432 no 2280 0.31946796819708 3286 650991 YMR113W FOL3 SGTC_3317 9138495 8.753 µM -0.46941450697722 0.334495804266256 no 2281 0.319386690486256 3292 17020139 SGTC_1411 3909-8223 150 µM -0.470500789807715 0.334123503752505 no 2282 0.318998635039793 3324 X1411 SGTC_1978 st071761 42 µM -0.470614121759544 0.334084671010844 no 2283 0.31895816060861 3217 5147680 SGTC_1443 4112-3303 14 µM -0.472133554715436 0.333564215042473 no 2284 0.318415731591297 3247 704433 SGTC_703 3875-0075 71.8 µM -0.472459911297881 0.333452468869037 no 2285 0.318299274841685 3243 2850814 SGTC_209 4077-0173 175.592 µM -0.472697244878789 0.333371213909677 no 2286 0.318214596244959 3268 15993494 SGTC_2315 7733312 200 µM -0.47295713196057 0.333282246365594 no 2287 0.318121881647934 3196 726316 SGTC_968 1309-0633 340 µM -0.473751066891926 0.333010515510957 no 2288 0.317838716326389 3332 3761976 SGTC_110 0850-0284 111.64 µM -0.474514160839797 0.332749422852461 no 2289 0.317566651129095 3137 3906265 SGTC_12 0849-0099 9.267 µM -0.4758082989124 0.332306818825579 no 2290 0.317105478478034 3296 6071388 SGTC_1111 tnp00062 510.699 nM -0.47645867036934 0.332084475581456 no 2291 0.316873822463029 3385 676306 SGTC_858 0438-0351 2.77 µM -0.477272290863982 0.331806405425311 no 2292 0.316584119788536 3279 2799119 SGTC_2368 9071271 200 µM -0.478260714634928 0.331468717583224 no 2293 0.316232326926045 3259 27209959 SGTC_1605 st000082 49.1 µM -0.481402874133371 0.330396132265521 no 2294 0.315115097184128 3338 1114022 SGTC_59 0330-0160 1.33 µM -0.481469095771026 0.330373542261944 no 2295 0.315091569484722 3346 4293482 SGTC_1449 4112-4002 201 µM -0.48276732089617 0.329930807256812 no 2296 0.314630478331983 3293 2059539 SGTC_1968 st069590 43.6 µM -0.483042203296045 0.329837094365333 no 2297 0.31453288527737 3324 6384066 SGTC_2576 guaiol 23.12 µM -0.484238710892626 0.329429305548883 no 2298 0.314108233438065 3272 227829 SGTC_3220 9131269 49.47 µM -0.484862221184543 0.32921688366118 no 2299 0.313887041206617 3355 17722206 SGTC_132 0417-1715 25.805 µM -0.487287303453831 0.328391214159802 no 2300 0.313027372000982 3420 6769098 SGTC_1013 4112-3890 241 µM -0.487477882173352 0.328326363126547 no 2301 0.312959856588506 3182 705171 SGTC_2823 7987624 58.44 µM -0.48863327392713 0.327933311722951 no 2302 0.312550675815167 3454 2239440 SGTC_775 4577-0580 57.3 µM -0.488666367708681 0.327922056391585 no 2303 0.312538959087461 3446 2006902 SGTC_2997 9067075 71.4286 µM -0.49012117578259 0.327427424749323 no 2304 0.312024077199416 3319 27209819 SGTC_344 k064-0035 6.43 µM -0.490412473081375 0.327328420646824 no 2305 0.311921026089751 3232 5088750 SGTC_2089 5281248 129.67 µM -0.490764874938661 0.327208664985366 no 2306 0.31179637793533 3311 2737878 SGTC_828 2074-0507 139 µM -0.491926116966188 0.326814169523949 no 2307 0.311385787319045 3379 X828 SGTC_3055 9094636 49.47 µM -0.492324310347961 0.326678940376027 no 2308 0.311245048528922 3428 25236176 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.493083547110127 0.326421161571974 no 2309 0.310976777831357 3347 4213774 SGTC_1892 st058411 7.36 µM -0.494131569674666 0.326065469344491 no 2310 0.310606631796331 3340 3934738 SGTC_948 3448-0295 75.3 µM -0.49419071819553 0.326045399423902 no 2311 0.310585747125596 3344 678569 SGTC_117 lucigenin 22.078 µM -0.494832901939928 0.325827529941334 no 2312 0.310359038646831 3348 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.494834825357689 0.325826877485243 no 2313 0.310358359735754 3409 1273210 SGTC_2949 9072542 2.23 µM -0.495372758573349 0.325644422311809 no 2314 0.310168510171155 3342 16457352 SGTC_2080 5212524 12.4 µM -0.496341331010972 0.325316009054994 no 2315 0.309826805234431 3367 260183 SGTC_1457 k015-0032 57.3 µM -0.496839755330537 0.325147061461729 no 2316 0.309651028939196 3352 4302660 SGTC_850 0388-0143 75.9 µM -0.497496908911046 0.324924365395679 no 2317 0.309419341080413 3263 67273 SGTC_2661 dactinomycin 12.96 µM -0.497983624338823 0.324759467685507 no 2318 0.309247792175133 3296 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2332 7982454 138.89 µM -0.49807451362255 0.324728678475664 no 2319 0.309215761722559 3359 2981748 SGTC_1497 4476-2978 41.3 µM -0.50039574102847 0.323942757137788 no 2320 0.308398225818534 3360 1528379 SGTC_2137 5261020 140 µM -0.503000844352322 0.323061654947833 no 2321 0.307481839259054 3288 763655 SGTC_2504 purpurogallin 52.29 µM -0.5035444725136 0.322877913096343 no 2322 0.307290760583081 3241 5281571 An antioxidant. SGTC_818 4072-2707 53.5 µM -0.505166142138753 0.322330059025141 no 2323 0.306721074329268 3259 882871 SGTC_931 2812-0076 566 µM -0.506986027243557 0.321715700431712 no 2324 0.306082311317975 3261 3450959 SGTC_1952 st077036 64.1 µM -0.507377469754583 0.321583620490282 no 2325 0.305944995507234 3371 2937007 SGTC_3273 9137859 49.47 µM -0.507445383407332 0.321560707463133 no 2326 0.305921174558927 3386 2377234 SGTC_1947 st076332 61.6 µM -0.508385737520217 0.32124351618023 no 2327 0.305591426517723 3400 24208416 SGTC_1255 0566-0045 221 µM -0.508816183099492 0.321098365856845 no 2328 0.30544053745306 3413 2788469 SGTC_2800 7887935 81.82 µM -0.508837647297115 0.321091128641465 no 2329 0.305433014224526 3387 2961002 SGTC_3067 9117431 49.47 µM -0.509895478260431 0.320734537527102 no 2330 0.305062344989828 3295 17150885 SGTC_2981 9013952 38.96 µM -0.515025907094252 0.319007438420623 no 2331 0.303267458242844 3325 2996344 SGTC_2640 pentamidine 10.38 µM -0.51517978031408 0.318955699192604 no 2332 0.303213698494679 3380 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1644 st010134 20.9 µM -0.516275558391955 0.318587350441735 no 2333 0.302830982234755 3396 3818134 SGTC_1949 st076024 69.1 µM -0.517332557217915 0.31823220723183 no 2334 0.302462015278445 3242 2921930 SGTC_2458 5808907 16.39 µM -0.518188745866921 0.317944657063812 no 2335 0.302163293051564 3455 2731747 SGTC_1208 2323-2347 50.3 µM -0.518219937661196 0.317934183399102 no 2336 0.302152412807722 3408 5412760 SGTC_1042 0350-0096 82 µM -0.518860381188852 0.31771916574988 no 2337 0.301929053782787 3295 3122515 SGTC_1153 4055-0057 267 µM -0.519486060743944 0.317509164193281 no 2338 0.301710915456588 3309 882706 SGTC_2624 nerol 100 µM -0.519906684405017 0.317368020095377 no 2339 0.301564308122104 3354 637566 A natural product oil. SGTC_774 k060-0086 136 µM -0.519916026028241 0.317364885730012 no 2340 0.3015610524863 3448 5911235 SGTC_3270 9137563 49.47 µM -0.520290813181873 0.317239145384134 no 2341 0.301430448994446 3359 17015724 SGTC_2846 9008642 19.48 µM -0.520361965783783 0.317215276209458 no 2342 0.30140565705485 3390 2992898 SGTC_2387 9077560 195.08 µM -0.521674976740571 0.316774944154674 no 2343 0.300948325097967 3301 5303272 SGTC_1338 1486-1223 76 µM -0.522662870983683 0.316443814414455 no 2344 0.300604440236837 3369 3444526 SGTC_1170 0310-0127 64.8 µM -0.52277039254199 0.316407783410236 no 2345 0.300567022812109 3344 774975 SGTC_2676 harmalol 100 µM -0.52607004299948 0.315302902962254 no 2346 0.299419770951156 3416 5459187 A monoamine oxidase inhibitor SGTC_2424 5537928 59.2 µM -0.526365946707978 0.315203900744711 no 2347 0.299316985597637 3335 5382802 SGTC_934 2950-0684 338 µM -0.529638928681481 0.314109726688238 no 2348 0.298181149141074 3457 1121253 SGTC_2874 9043904 71.43 µM -0.53263796583592 0.313108565931011 no 2349 0.297142107840838 3341 4463428 SGTC_1075 aripiprazole 15.2 µM -0.532699752443505 0.313087954313439 no 2350 0.297120718770811 3348 60795 An atypical antipschotic. YIL048W NEO1 SGTC_906 1165-0455 526 µM -0.533979093361517 0.31266130568404 no 2351 0.296677999324898 3393 3252859 SGTC_1268 0828-0275 2.46 µM -0.534050105080977 0.312637631262407 no 2352 0.296653434375719 3416 745337 SGTC_2203 7227154 166.4 µM -0.534863345203306 0.312366562286725 no 2353 0.296372178211375 3423 896304 SGTC_1900 st060200 72.8 µM -0.535239580502294 0.312241189975056 no 2354 0.296242099964103 3335 688945 SGTC_2238 6671620 73.2395 µM -0.537539065150919 0.311475409098491 no 2355 0.295447654081961 3386 729941 SGTC_2224 6650123 117.647 µM -0.537860102254686 0.31136856116526 no 2356 0.295336817404107 3379 2908370 SGTC_1074 carmofur 3.8 µM -0.538202130027227 0.311254744573768 no 2357 0.295218754843054 3430 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3201 9113999 49.47 µM -0.539351811027943 0.310872297496157 no 2358 0.294822062546735 3431 16649224 SGTC_390 dec-rvkr-cmk 16.7 µM -0.539818561281399 0.310717088971082 no 2359 0.294661082616668 3390 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1633 st005664 67.9 µM -0.539833128414806 0.310712245502061 no 2360 0.294656059134511 3338 2063822 SGTC_1857 st056007 79.3 µM -0.540381277520712 0.310530013642251 no 2361 0.294467058399578 3436 619834 SGTC_570 0987-0065 62.6 µM -0.541078997509593 0.310298124275965 no 2362 0.294226566893334 3330 3104428 SGTC_1242 0402-0103 60.1 µM -0.542863610570978 0.309705345896578 no 2363 0.293611856148075 3381 432868 SGTC_995 3931-2021 34.6 µM -0.543305797777899 0.309558545063896 no 2364 0.293459636535059 3395 730143 SGTC_1209 2323-2347 50.3 µM -0.544074690796447 0.309303354180293 no 2365 0.293195037990592 3435 5412760 SGTC_1624 st003710 6.25 µM -0.544408268079307 0.309192670516786 no 2366 0.293080278719353 3430 24207033 SGTC_2433 5607874 27.82 µM -0.544783599827283 0.309068153083313 no 2367 0.292951179739842 3388 2252428 SGTC_122 0236-0016 402.397 µM -0.544895716723478 0.309030962220439 no 2368 0.292912621169886 3465 6808838 SGTC_3079 9117512 49.47 µM -0.546165083989128 0.308610030589467 no 2369 0.292476232386924 3443 7185044 SGTC_119 0121-0043 24.815 µM -0.547048851725212 0.308317115024664 no 2370 0.292172585296149 3489 1092378 SGTC_1283 0922-0125 16.4 µM -0.547494153976705 0.308169570465003 no 2371 0.292019642850172 3405 3360884 SGTC_560 2332-1943 155 µM -0.548387503257825 0.307873665373468 no 2372 0.29171292768862 3428 21177716 SGTC_120 rhodamine 6G 52.259 µM -0.549252556749573 0.307587251742002 no 2373 0.291416070529457 3351 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2099 5377090 177.372 µM -0.54970971681836 0.307435936334911 no 2374 0.291259245567661 3416 2243829 SGTC_2205 7238770 200 µM -0.551243350565911 0.306928558362653 no 2375 0.290733433223806 3455 279867 SGTC_376 3970-0862 59.1 µM -0.551268397401962 0.306920275085854 no 2376 0.290724849503156 3432 3135186 SGTC_728 3030-5151 22.5 µM -0.55195827226056 0.306692164291583 no 2377 0.290488471310363 3435 3125388 SGTC_3318 9139014 38.6185 µM -0.552514497076733 0.306508300093487 no 2378 0.29029795239103 3428 16643984 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.554912212650182 0.305716275440275 no 2379 0.289477354032508 3446 3256 An antibiotic and ribosome inhibitor. SGTC_461 N-acetylfarnesylcysteine 136 µM -0.555533134928906 0.30551131734842 no 2380 0.289265026241193 3465 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_564 3555-0129 330 µM -0.55626297043482 0.30527048637162 no 2381 0.289015548598344 3411 563260 SGTC_921 1561-0023 372 µM -0.556753092246988 0.305108803363979 no 2382 0.288848068450839 3447 24050882 SGTC_2961 9083290 32.55 µM -0.557915215548981 0.304725590309446 no 2383 0.288451140495269 3445 17741490 SGTC_1518 st038567 90.8 µM -0.559496100578632 0.30420463338465 no 2384 0.287911595866608 3456 77966 SGTC_3205 9113483 49.47 µM -0.560002862135552 0.304037721735287 no 2385 0.287738742730533 3482 17018033 SGTC_2998 9066762 71.4286 µM -0.563009190090331 0.303048370533231 no 2386 0.286714313011889 3532 4945196 SGTC_1950 st077106 7.18 µM -0.564110087543046 0.30268643729614 no 2387 0.286339606647354 3401 13831864 SGTC_1852 st056254 31.4 µM -0.564325905944057 0.302615507118353 no 2388 0.286266176997021 3363 442583 SGTC_3104 9120930 49.47 µM -0.565423919307374 0.302254753004668 no 2389 0.285892729512226 3485 17014836 SGTC_3188 9110789 49.47 µM -0.566188631787835 0.30200361950995 no 2390 0.285632778551626 3513 849217 SGTC_996 3970-0799 1.8 µM -0.566936539194645 0.301758095535318 no 2391 0.285378649033241 3504 6615648 YGL040C HEM2 SGTC_2044 5102272 200 µM -0.568485490350536 0.301249889515704 no 2392 0.284852677649278 3470 592666 SGTC_2087 5276107 200 µM -0.569527663155558 0.300908172976609 no 2393 0.284499051513188 3456 144405 SGTC_2556 citropten 84.59 µM -0.569758752088477 0.300832425243178 no 2394 0.284420667703204 3390 2775 A potential DNA crosslinker. SGTC_1522 st012842 45.6 µM -0.570767213040921 0.300501966508301 no 2395 0.284078725357939 3416 3491067 YOR116C RPO31 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.575408450745762 0.2989832151303 no 2396 0.282507545074363 3479 616764 SGTC_753 1322-0200 289 µM -0.575621605832001 0.298913548227586 no 2397 0.282435486977335 3524 5403907 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.577246666405996 0.298382661402875 no 2398 0.281886418257149 3490 66535 A nucleotide analog. SGTC_2818 7996756 12.99 µM -0.579219659625904 0.297738686814025 no 2399 0.281220483546949 3435 2241621 SGTC_2849 9019321 12.99 µM -0.57938671423289 0.297684190197995 no 2400 0.28116413332824 3462 16489627 SGTC_832 4083-0019 164 µM -0.581258593395269 0.297073856567206 no 2401 0.280533091415132 3532 1990758 SGTC_2455 5377712 9.75 µM -0.582203233783406 0.296766070231674 no 2402 0.280214897711676 3459 2243908 SGTC_3061 glucosamine 200 µM -0.582657730150045 0.29661803652626 no 2403 0.280061866982221 3452 91431 and experimental redox chemotherapeutic SGTC_621 3584-0052 32.1 µM -0.582883080047092 0.296544650508042 no 2404 0.279986005802673 3521 2273927 SGTC_736 0958-0254 92.6 µM -0.582904617040822 0.296537637342783 no 2405 0.27997875616898 3527 6812352 SGTC_2768 sulfasalazine 50.2 µM -0.583433986201984 0.296365280939141 no 2406 0.279800592204051 3551 5384001 An antioxidant and salicylic acid derivative. SGTC_1868 st057644 42.7 µM -0.583653931135009 0.296293682950885 no 2407 0.27972658392987 3419 688665 SGTC_2416 tofa 880 nM -0.583889393955664 0.296217042265552 no 2408 0.279647364641025 3370 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2382 9035899 200 µM -0.58416343652485 0.296127855727788 no 2409 0.279555179266138 3489 6462679 SGTC_2091 4-phenylthiadiazole 200 µM -0.584623003774255 0.295978318263949 no 2410 0.2794006182372 3432 270010 SGTC_1048 3161-0300 24.5 µM -0.58506695276969 0.295833895714741 no 2411 0.279251349346104 3508 2165101 SGTC_2511 berberine 10.47 µM -0.585168990491723 0.295800706053757 no 2412 0.279217046699388 3471 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1822 st052468 42 µM -0.585282730685481 0.29576371196307 no 2413 0.279178812374941 3422 2873678 SGTC_195 4234-0266 16.654 µM -0.586550461141398 0.295351525562047 no 2414 0.278752830911473 3439 2303354 SGTC_421 streptovitacin 30 mM -0.586978936389402 0.295212272083629 no 2415 0.278608926678719 3521 91467 include heat shock SGTC_2986 9022445 71.43 µM -0.587752953423316 0.294960794958109 no 2416 0.278349063318614 3502 6459286 SGTC_923 1900-2434 73.3 µM -0.589121801294176 0.294516299873328 no 2417 0.277889784792353 3481 5910570 SGTC_2888 9058547 12.99 µM -0.590968418783193 0.293917152744608 no 2418 0.277270790768288 3437 16476514 SGTC_1988 st071872 53.4 µM -0.591204768861563 0.293840508123163 no 2419 0.277191613924995 3533 16414116 SGTC_1921 5740136 50 µM -0.591279997999725 0.293816114434115 no 2420 0.27716641462238 3516 1774243 SGTC_1512 0259-0544 12.2 µM -0.592285418016153 0.293490188395983 no 2421 0.276829739407136 3497 18476 SGTC_1725 st036284 20.55 µM -0.593185683002534 0.293198492540774 no 2422 0.276528446508201 3549 707914 SGTC_2724 maprotiline 69.64 µM -0.593796794692599 0.293000562186577 no 2423 0.276324016578916 3523 4011 A tricyclic antidepressant. SGTC_1764 st044502 93.5 µM -0.595364266998335 0.29249316392201 no 2424 0.275800002788615 3518 8407 SGTC_1901 st060216 58.6 µM -0.600075023539902 0.290970732936471 no 2425 0.274228118623467 3533 688792 SGTC_93 0109-0045 59.227 µM -0.600714927285558 0.290764213640119 no 2426 0.27401493749766 3572 88733 SGTC_1007 4101-0031 70 µM -0.60118188987702 0.290613551767002 no 2427 0.273859422664583 3524 1146276 SGTC_2274 7947094 46.08 µM -0.601354912798257 0.29055773653283 no 2428 0.273801811078244 3542 2971028 SGTC_1897 st060201 15 µM -0.603765607916987 0.289780595928542 no 2429 0.272999743958521 3499 611878 SGTC_885 0865-0106 16.8 µM -0.605140131473891 0.289337925017806 no 2430 0.272542945525965 3498 2793380 SGTC_1553 gossypol 38.6 µM -0.605794928944864 0.289127156626569 no 2431 0.272325468770452 3470 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1080 nisoldipine 24.4 µM -0.606136444235634 0.289017257201995 no 2432 0.272212076105031 3473 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2109 5483026 200 µM -0.607233553247411 0.288664341180023 no 2433 0.271847963956981 3516 759335 SGTC_2858 9025781 8.96 µM -0.607298215654763 0.288643547030389 no 2434 0.271826511149064 3573 4894980 YPL153C RAD53 SGTC_2000 st075254 36.4 µM -0.608379038016229 0.288296080465067 no 2435 0.27146805547338 3506 17234175 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.609505134431615 0.287934268991534 no 2436 0.271094835258874 3529 65057 A dermal irritant. YDR527W RBA50 SGTC_1530 rhein 70.4 µM -0.609675553985174 0.287879532372566 no 2437 0.271038375698804 3558 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_826 1683-5028 118 µM -0.60991689207723 0.287802026018111 no 2438 0.270958431044789 3528 722377 SGTC_3328 9140624 29.0385 µM -0.609951905929214 0.287790782047529 no 2439 0.270946833478941 3556 4904392 SGTC_3249 9135183 49.47 µM -0.610177403554325 0.287718373145767 no 2440 0.270872148301007 3577 4902779 SGTC_302 1094-0063 18.9 µM -0.612429765732528 0.28699559636154 no 2441 0.270126726600215 3490 5440289 SGTC_2939 9044578 71.43 µM -0.613693409488522 0.286590473537469 no 2442 0.269708972130658 3520 2653634 SGTC_2797 7859098 81.82 µM -0.616631275336317 0.285649646756528 no 2443 0.268738980363373 3521 972681 SGTC_89 0302-0250 142.109 µM -0.61768640986763 0.285312107865561 no 2444 0.268391036040515 3604 4203518 YLR208W SEC13 SGTC_153 4077-0274 519.67 µM -0.618693993284704 0.28498995809194 no 2445 0.268058983913892 3650 3121976 SGTC_1027 k015-0025 8.67 µM -0.619296421313337 0.284797429587769 no 2446 0.267860550791627 3537 3598955 SGTC_1251 0490-5699 265 µM -0.619324587553033 0.284788429526889 no 2447 0.267851274955033 3597 3883818 SGTC_21 0849-0113 22.993 µM -0.619790804746775 0.284639477173065 no 2448 0.267697761656553 3520 1560156 SGTC_1059 3448-6867 171 µM -0.624643175789594 0.283091399043909 no 2449 0.26610263788274 3552 3934407 SGTC_587 k089-0003 57 µM -0.624844237390624 0.28302734055515 no 2450 0.266036646745406 3519 9659696 SGTC_1173 0443-0020 122 µM -0.625886190557375 0.282695484419842 no 2451 0.265694796456463 3538 5331295 SGTC_441 propafenone 146 µM -0.627766317696524 0.282097148186205 no 2452 0.265078517025919 3537 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_414 piperonyl butoxide 100 µM -0.628413423334121 0.281891352854408 no 2453 0.264866572924441 3496 5794 A potent inhibitor of cytochrome P450. SGTC_1815 st051655 58.2 µM -0.629301706230486 0.281608975140818 no 2454 0.264575777271254 3536 5984156 SGTC_2536 dehydroabietamide 32.04 µM -0.634361658706549 0.280003065487971 no 2455 0.262922412809503 3589 3983547 SGTC_2892 9047358 58.44 µM -0.636227614869256 0.279411977509174 no 2456 0.262314038318816 3533 6466771 SGTC_315 k915-0449 187 µM -0.636363320379148 0.279369013070601 no 2457 0.262269821170943 3579 20970215 YNL149C PGA2 SGTC_2323 6148992 148.28 µM -0.638144204433773 0.278805481820844 no 2458 0.261689906838844 3520 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2227 7312221 64.1025 µM -0.639535760757528 0.278365532260821 no 2459 0.261237228767069 3594 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1733 st037357 54.9 µM -0.640741681190031 0.27798454655452 no 2460 0.260845264359468 3553 1272339 YGL099W LSG1 SGTC_638 3970-0837 4.09 µM -0.641254142952344 0.277822721897898 no 2461 0.26067878881862 3559 4118451 YLR208W SEC13 SGTC_1408 3909-7976 48.8 µM -0.642071444062961 0.2775647305883 no 2462 0.260413398016788 3596 24152374 SGTC_2869 9037858 32.47 µM -0.645356566569978 0.276528923118998 no 2463 0.259348071556972 3563 27187042 SGTC_984 1492-0255 2.91 µM -0.645445353956476 0.276500954552838 no 2464 0.259319310138207 3532 1585198 SGTC_3010 9080089 71.4286 µM -0.646347551467519 0.276216835532275 no 2465 0.259027149494865 3597 17027233 SGTC_1557 sumaresinolic acid 42.3 µM -0.646543498067851 0.27615514719341 no 2466 0.258963718175711 3547 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2750 bromebric acid 70.15 µM -0.647724221294359 0.275783572523885 no 2467 0.258581667694213 3603 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_520 3584-0023 682 µM -0.647742635087117 0.275777779632915 no 2468 0.258575711795195 3527 1340790 SGTC_353 1988-1175 58.3 µM -0.647814180161621 0.275755272462849 no 2469 0.258552571379229 3479 2788357 SGTC_2591 skatole 100 µM -0.648181094454055 0.275639860084088 no 2470 0.258433914106133 3604 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1878 temozolomide 1 mM -0.649729289054977 0.275153139309194 no 2471 0.257933550650323 3572 5394 DNA alkylating agent. SGTC_433 pimozide 108 µM -0.650795080895877 0.274818322240994 no 2472 0.25758938802306 3528 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1905 st060207 84.5 µM -0.653627024328044 0.273929647998561 no 2473 0.256676064539438 3541 1948547 SGTC_1835 st008666 49.2 µM -0.653698091695421 0.273907365082176 no 2474 0.256653166475558 3533 690455 SGTC_234 nsc-17383 10.7 µM -0.653767793798016 0.273885511110085 no 2475 0.256630709336312 3635 408974 SGTC_274 sirtinol 40.1 µM -0.655943997944962 0.273203631263986 no 2476 0.255930078829946 3598 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_3341 9147222 25.867 µM -0.656935536767441 0.272893227099111 no 2477 0.255611183489718 3590 1939759 SGTC_1106 tegaserod maleate 11.7 µM -0.657504429046728 0.27271521268224 no 2478 0.255428312028829 3605 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1294 1000-1494 117 µM -0.658581819060085 0.27237824012722 no 2479 0.255082170475932 3591 712797 YDL207W GLE1 SGTC_2887 9044784 58.44 µM -0.659721417797011 0.272022035933962 no 2480 0.25471630983353 3622 6465546 SGTC_149 3970-0822 46.1 µM -0.66118589595494 0.27156462461373 no 2481 0.254246552546015 3662 3114250 YBL034C STU1 SGTC_2719 novobiocin 32.65 µM -0.662648871700464 0.271108065317785 no 2482 0.253777731126423 3618 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_92 0063-0024 660.874 µM -0.662973533861746 0.271006798045547 no 2483 0.25367375230305 3668 3594437 SGTC_2656 pseudo-anisatin 100 µM -0.663296269714609 0.270906150325328 no 2484 0.253570412593624 3637 6708809 A neurotoxin. SGTC_2610 ononetin 44.17 µM -0.664393119960327 0.270564228409044 no 2485 0.253219367569983 3620 259632 SGTC_901 1112-0062 60.1 µM -0.665216301854501 0.270307759009571 no 2486 0.252956077595586 3624 1908457 SGTC_495 decylubiquinone 155 µM -0.665333761234458 0.270271173440395 no 2487 0.252918520639713 3587 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2996 9066192 71.4286 µM -0.668917597585406 0.269156092405464 no 2488 0.251774022005789 3619 6472854 SGTC_3245 9134821 49.47 µM -0.670329442410739 0.268717443197632 no 2489 0.251323901153813 3593 17014901 SGTC_733 4069-0007 56.1 µM -0.670487425538377 0.268668381420204 no 2490 0.251273559845833 3663 5717425 YNL287W SEC21 SGTC_2515 chrysin 20.77 µM -0.670643793713665 0.268619825599929 no 2491 0.251223738392932 3621 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_620 0109-0052 432 µM -0.670853070962055 0.268554847228996 no 2492 0.251157067420902 3632 493037 SGTC_2923 7992654 58.14 µM -0.670903301474666 0.268539252362194 no 2493 0.251141066514682 3649 2985126 SGTC_2882 9058044 58.44 µM -0.671807889592073 0.268258486436394 no 2494 0.250853002709475 3587 18076804 SGTC_1621 st003705 32.4 µM -0.67238505034174 0.268079424574875 no 2495 0.250669298767633 3658 24207032 SGTC_62 0180-0423 3.232 µM -0.672808959824369 0.267947946652146 no 2496 0.250534418423568 3606 30102 YGL099W LSG1 SGTC_1406 3909-7906 11.9 µM -0.673230316708368 0.267817292619169 no 2497 0.250400388387306 3645 X1406 SGTC_2025 5147754 141 µM -0.673309969984735 0.267792597397297 no 2498 0.250375055630498 3641 315777 YLR208W SEC13 SGTC_827 3253-0474 693 µM -0.673776623282708 0.267647942073242 no 2499 0.250226669516496 3632 5402065 SGTC_1844 rapamycin 4 nM -0.676368498368129 0.266845218311488 no 2500 0.249403356308261 3621 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2781 5567276 71.43 µM -0.676542581437971 0.266791347065092 no 2501 0.249348110193573 3640 2853274 SGTC_456 gingerol 170 µM -0.67685501365361 0.266694676475059 no 2502 0.249248974617458 3692 442793 A herb. SGTC_2280 7785178 200 µM -0.677804495609484 0.266401003123082 no 2503 0.248947830129967 3635 2954328 SGTC_762 1165-0429 115 µM -0.678093082558617 0.266311776043341 no 2504 0.248856338214884 3633 5967793 SGTC_2557 derrustone 83.84 µM -0.67955315619588 0.265860573492928 no 2505 0.248393719523008 3642 629853 An antioxidant. SGTC_2984 9022109 38.96 µM -0.679711203025267 0.265811755962284 no 2506 0.248343670504562 3682 6459207 SGTC_1096 rimcazole 32.2 µM -0.680397877766382 0.265599708520749 no 2507 0.248126282216771 3591 18528119 A dopamine reuptake inhibitor. SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.682528717723465 0.264942244694317 no 2508 0.247452345119277 3654 5379071 SGTC_956 1185-0240 191 µM -0.686406423606848 0.263747916699537 no 2509 0.246228427450512 3660 1416193 SGTC_444 curcumin 90.4 µM -0.687038275260916 0.26355356775318 no 2510 0.24602930453351 3615 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1714 st033236 13.627 µM -0.687653091809247 0.263364528748701 no 2511 0.245835633049543 3692 2916566 SGTC_2052 5265182 7.135 µM -0.688071761126139 0.263235839202752 no 2512 0.245703796157448 3650 1239884 SGTC_873 0591-4978 488 µM -0.689531833935168 0.262787297070321 no 2513 0.245244323679372 3709 3305145 SGTC_41 0478-0632 82.643 µM -0.689735802494586 0.262724667977166 no 2514 0.245180173305077 3654 3750424 SGTC_55 0767-0285 6.563 µM -0.690986192936904 0.262340899188533 no 2515 0.244787108925373 3642 3116166 SGTC_392 N-ethylmaleimide 8.33 µM -0.691334510976343 0.262234044857094 no 2516 0.244677674434107 3631 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_401 neomycin 50 µM -0.692012087213889 0.262026247118435 no 2517 0.244464869157203 3643 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2929 9013348 24.6 µM -0.692340373404865 0.26192559932311 no 2518 0.244361800714588 3680 2995952 SGTC_1459 k035-0031 35.7 µM -0.692871486642875 0.261762809679761 no 2519 0.244195102475508 3560 3877128 YMR208W ERG12 SGTC_556 4058-0063 51.5 µM -0.694294488759061 0.261326906303076 no 2520 0.243748773261459 3726 6615692 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.694552523131156 0.261247903471306 no 2521 0.243667887139495 3712 688788 SGTC_482 fipronil 114 µM -0.696148517384635 0.260759527965928 no 2522 0.243167912479868 3700 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2057 5236571 38.335 µM -0.696709660553784 0.260587929396533 no 2523 0.24299225590696 3661 54684039 YBR257W POP4 SGTC_1302 1159-0335 255 µM -0.697131696703741 0.260458908311735 no 2524 0.242860189719033 3671 649284 SGTC_100 0086-0128 49.5915 µM -0.697824765239983 0.26024710104543 no 2525 0.2426433946755 3650 93297 SGTC_567 1080-0542 68.4 µM -0.698878854837408 0.259925133103909 no 2526 0.242313871544982 3608 5950415 SGTC_2105 5350118 200 µM -0.698957785162653 0.259901032385982 no 2527 0.242289206586238 3689 2133313 SGTC_2689 tacrolimus 100 µM -0.699190168359712 0.259830082804096 no 2528 0.242216596998639 3675 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_819 1013-0258 27.7 µM -0.701657993255045 0.259077241108355 no 2529 0.241446237857229 3704 5753198 SGTC_1715 st032160 10.2275 µM -0.703020249896388 0.258662150889518 no 2530 0.241021564965741 3603 5289825 SGTC_2290 7904846 200 µM -0.704019528607484 0.258357881934225 no 2531 0.240710306060583 3733 2962154 SGTC_2760 etidronate 98.04 µM -0.705953798028722 0.257769446352828 no 2532 0.240108434983478 3687 3305 A chelator and antioxidant. SGTC_3122 9126309 49.47 µM -0.706242654247993 0.257681631424405 no 2533 0.240018624369352 3732 17591206 SGTC_2561 acetosyringone 100 µM -0.707264587744624 0.257371079031265 no 2534 0.23970103387431 3698 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2002 4023503 131 µM -0.708083772581474 0.257122279847758 no 2535 0.239446618102764 3731 4736863 YCR052W RSC6 SGTC_180 1486-1293 102.781 µM -0.708260075681764 0.257068750212457 no 2536 0.239391882607679 3705 4140536 SGTC_2824 7998404 51.95 µM -0.708562646297214 0.25697689639579 no 2537 0.239297961718219 3660 837851 SGTC_603 3794-0023 45.9 µM -0.708686379703096 0.256939338561346 no 2538 0.239259559454271 3678 3802260 SGTC_990 3985-0011 41.3 µM -0.709819625410839 0.256595487932509 no 2539 0.2389079986675 3675 5399565 YGL099W LSG1 SGTC_1194 1488-0194 225 µM -0.710653213617522 0.256342712767359 no 2540 0.238649579462969 3658 1391452 SGTC_2045 5106652 78.05 µM -0.711189581701672 0.256180134521977 no 2541 0.238483381854376 3667 673349 SGTC_2794 7785382 27.27 µM -0.711690393404267 0.256028382303816 no 2542 0.238328258874481 3666 2205081 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.711993871350272 0.255936447508252 no 2543 0.238234285565354 3679 75037 A free radical scavenger. SGTC_2344 7990960 76.95 µM -0.712466613387508 0.255793270626058 no 2544 0.238087939318613 3686 140813 SGTC_1271 0832-2808 169 µM -0.719072562117303 0.253796944524562 no 2545 0.236048106007098 3733 3663794 SGTC_3223 9129970 49.47 µM -0.719372444161456 0.253706514271711 no 2546 0.235955735275427 3744 17248386 SGTC_1119 parthenolide 318.541 nM -0.721336907682009 0.253114543632419 no 2547 0.23535112720576 3836 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1925 st057770 10.1 µM -0.72309283416048 0.25258602905707 no 2548 0.234811425737565 3690 5989122 SGTC_2173 5763948 167 µM -0.723475261179505 0.252470999869836 no 2549 0.234693973778353 3724 2867177 SGTC_191 3914-0123 66.505 µM -0.723650912547653 0.252418175423514 no 2550 0.23464003817181 3649 3144412 SGTC_1345 1488-0192 31.4 µM -0.724367203384095 0.252202822301541 no 2551 0.234420164496291 3729 658348 SGTC_732 3970-1727 52.7 µM -0.724459798070601 0.252174990746549 no 2552 0.234391749820484 3718 1275699 SGTC_2653 dihydrofissinolide 100 µM -0.724992663061771 0.252014856875398 no 2553 0.234228265759581 3759 6857746 SGTC_205 1486-1330 71.903 µM -0.725273689671982 0.251930425806007 no 2554 0.234142071656412 3701 4118834 SGTC_3088 9117578 49.47 µM -0.725474776863272 0.251870020738963 no 2555 0.234080406676802 3768 678341 SGTC_3185 9108267 49.47 µM -0.725949880313429 0.251727333641644 no 2556 0.233934748176838 3676 4910486 SGTC_698 k064-0052 127 µM -0.727066946052682 0.25139201522804 no 2557 0.233592473057639 3770 5088751 SGTC_809 3998-0021 90 µM -0.728204564783508 0.251050770065818 no 2558 0.233244185982152 3648 715485 SGTC_1384 3089-0840 101 µM -0.729401864796373 0.250691887512877 no 2559 0.232877938719134 3685 1069836 SGTC_1272 0839-0021 27 µM -0.730741523350425 0.250290656265738 no 2560 0.232468523788261 3754 5027250 SGTC_260 nsc-65238 3.989 µM -0.731151232752783 0.250168015248817 no 2561 0.232343391899218 3659 3246252 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.731686351211452 0.250007882724332 no 2562 0.23218001449675 3726 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_677 0929-0063 136 µM -0.731741188309258 0.249991475967318 no 2563 0.232163275755326 3689 1539583 SGTC_2136 5328288 199.296 µM -0.732023903442534 0.249906899257488 no 2564 0.232076989076328 3734 262395 SGTC_1930 st074634 34.3 µM -0.732613867160071 0.249730455366645 no 2565 0.231896985445043 3672 684253 YOR116C RPO31 SGTC_1908 st060353 56.5 µM -0.733655111688113 0.24941920577505 no 2566 0.231579481483868 3747 4227716 SGTC_334 1502-1024 68.5 µM -0.734296474577931 0.249227591761667 no 2567 0.231384033035405 3758 3296216 SGTC_1506 4226-2149 212 µM -0.735433885135627 0.248887970812123 no 2568 0.231037645725132 3763 991114 SGTC_2759 disulfiram 3.38 µM -0.736051651506363 0.248703614403245 no 2569 0.23084963235199 3695 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1145 3546-0597 10.2 µM -0.73694356685083 0.248437573663534 no 2570 0.230578334226512 3704 875334 SGTC_2621 lithochol-11-enic acid 100 µM -0.738080348328206 0.248098714154949 no 2571 0.230232812411563 3709 6708711 SGTC_3074 9116018 49.47 µM -0.738369823175603 0.24801246493718 no 2572 0.230144873557136 3779 17027303 SGTC_226 1,3-diallylurea 8.28947 mM -0.73912072423164 0.247788808078522 no 2573 0.229916846781312 3694 74537 YKL182W FAS1 SGTC_1065 prochlorperazine maleate 2.48 µM -0.739206855570115 0.24776316063305 no 2574 0.22989069929042 3775 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_470 aa-861 153 µM -0.739447725623535 0.247691443955652 no 2575 0.229817585526713 3750 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.739756192471114 0.247599617192762 no 2576 0.229723972428639 3753 521171 SGTC_29 0299-0004 12.984 µM -0.74005380626465 0.247511038489102 no 2577 0.229633673245689 3634 16871 A napthoquinone isolated from Swertia calycina. SGTC_1990 st072050 59.8 µM -0.740262390145931 0.247448967824514 no 2578 0.229570398535297 3736 17233948 SGTC_2492 derrusnin 100 µM -0.740878787992078 0.24726558797003 no 2579 0.229383469011048 3676 1715307 Part of coumarin class of compounds. SGTC_591 4299-0174 154 µM -0.741212830936526 0.247166239750276 no 2580 0.229282202417471 3728 5509088 SGTC_1546 5-methoxyflavanone 78.7 µM -0.741837976368233 0.246980371672101 no 2581 0.229092754184412 3764 147795 SGTC_159 3970-0959 50 µM -0.742026223886332 0.246924416623714 no 2582 0.229035723609382 3827 6615653 SGTC_2244 6635614 200 µM -0.744474759258904 0.246197227757268 no 2583 0.228294652914056 3671 836499 SGTC_3217 9129673 49.47 µM -0.744682613278997 0.246135550256232 no 2584 0.228231806192995 3735 17248312 SGTC_2924 9010168 62.78 µM -0.746088348587612 0.245718637439605 no 2585 0.227807023609915 3829 2993929 SGTC_2951 9072950 58.06 µM -0.746265225855167 0.245666206069589 no 2586 0.227753606684251 3760 16488155 SGTC_1187 1391-0724 117 µM -0.746735017079679 0.245526975984271 no 2587 0.227611763992367 3817 6997986 SGTC_336 4111-0029 111 µM -0.747561094191985 0.245282257762374 no 2588 0.227362469606378 3704 3131175 SGTC_806 3966-4455 5.86 µM -0.747757096478077 0.245224213027489 no 2589 0.227303342425763 3738 714982 SGTC_750 4073-0104 132 µM -0.747865947582258 0.245191980708276 no 2590 0.227270509515894 3619 22330957 SGTC_1323 1348-1351 11.2 µM -0.748138789191203 0.245111198542276 no 2591 0.227188223668138 3713 6989654 SGTC_3085 9117376 49.47 µM -0.752249410133812 0.243895871829662 no 2592 0.225950542425521 3848 16480349 SGTC_3247 9135149 49.47 µM -0.753341799853759 0.243573448799961 no 2593 0.225622273288102 3736 8934436 YOR116C RPO31 SGTC_2459 5811157 9.22 µM -0.754363098325624 0.243272216964344 no 2594 0.2253156117067 3746 2870684 YBR192W RIM2 SGTC_2463 5473429 200 µM -0.754383252307945 0.243266274576908 no 2595 0.225309562519441 3760 5399405 SGTC_1047 2043-3044 82 µM -0.754408607808852 0.243258798636843 no 2596 0.225301952234898 3766 669592 SGTC_6 0844-0013 19.835 µM -0.754593085226294 0.243204410150483 no 2597 0.225246586950618 3859 1584900 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.754710560386387 0.243169779006289 no 2598 0.225211334371696 3730 97141 SGTC_1078 idebenone 36.1 µM -0.755331178787345 0.242986867774906 no 2599 0.225025147732902 3817 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1020 4335-0961 93.3 µM -0.755730493152477 0.242869219547229 no 2600 0.224905398835218 3720 669075 SGTC_1631 benzylvanillin 81.9 µM -0.756393771047034 0.242673869049775 no 2601 0.224706570754636 3818 75506 SGTC_1653 st012112 65 µM -0.757581490579627 0.242324271161845 no 2602 0.224350782169144 3768 720429 SGTC_2058 5236698 133 µM -0.757719406044632 0.242283694291688 no 2603 0.224309489487243 3770 766665 SGTC_3129 9127257 49.47 µM -0.757910871292244 0.242227368349605 no 2604 0.224252170846368 3770 837894 SGTC_2296 7971656 126.45 µM -0.75841550117358 0.242078948510114 no 2605 0.224101140466747 3829 666570 SGTC_455 paf C-16 10 µM -0.758571343377703 0.24203312275639 no 2606 0.224054510224129 3743 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2406 ethylparaben 405.7 µM -0.760072455803858 0.241591958241092 no 2607 0.223605637993429 3808 8434 A possible steroid mimic. SGTC_2478 5763493 32.33 µM -0.760631078201527 0.241427895285713 no 2608 0.223438725813518 3736 1365576 YLR208W SEC13 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.762147488725633 0.240982842860919 no 2609 0.222985991282324 3820 1609 A potent and irreversible inhibitor of serine proteases. SGTC_3329 9141233 27.5565 µM -0.762948785001951 0.240747850136935 no 2610 0.222746970049846 3761 4909101 YNL103W MET4 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.762978097287971 0.240739256213428 no 2611 0.222738229163416 3765 6857784 SGTC_472 calcifediol 10 µM -0.763811793069259 0.240494899003088 no 2612 0.222489704000725 3810 5283731 A vitamin D metabolite. SGTC_387 norethindrone acetate 66.7 µM -0.765456778170052 0.240013148373003 no 2613 0.22199979717057 3784 541197 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.76567061035079 0.239950564110747 no 2614 0.221936159278116 3806 368090 SGTC_1313 1220-0047 237 µM -0.766749466474716 0.239634940973615 no 2615 0.221615243360604 3777 3528706 SGTC_1017 4239-0030 168 µM -0.767520936535139 0.239409383731887 no 2616 0.221385925033731 3834 1149593 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.768828186062493 0.239027443725147 no 2617 0.220997656976278 3817 23665772 A membrane-active detergent. SGTC_1348 1493-0373 93.8 µM -0.769236029137087 0.238908352139853 no 2618 0.220876602731144 3776 3010129 SGTC_2666 tannic acid 100 µM -0.769534353634781 0.23882126090921 no 2619 0.220788079369424 3787 16134267 A thiamine antagonist. SGTC_509 pifithrin 175 µM -0.770914038528455 0.238418709170189 no 2620 0.220378942725659 3820 4817 A p53 inhibitor. SGTC_97 0535-0701 19.132 µM -0.773850475828204 0.237563180826308 no 2621 0.219509609536138 3718 2832013 YGL099W LSG1 SGTC_2165 5727197 32.143 µM -0.775469467739806 0.237092210490365 no 2622 0.219031150142782 3885 1361712 SGTC_1698 5-fluorocytosine 1.055 µM -0.775789405428084 0.236999200261347 no 2623 0.218936670234006 3804 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2622 2-methoxyxanthone 59.94 µM -0.775944027721304 0.236954256650779 no 2624 0.218891017558677 3804 71034 A hepatoprotective. SGTC_619 1652-1634 108 µM -0.776663688801469 0.236745136524637 no 2625 0.218678607637694 3760 5400454 SGTC_569 4130-2812 160 µM -0.777140290681358 0.23660670077056 no 2626 0.218538002626358 3662 743552 SGTC_2117 5521686 200 µM -0.777414764786507 0.236526996100774 no 2627 0.218457052097772 3762 803312 SGTC_2031 5180455 200 µM -0.777592462710504 0.236475402194036 no 2628 0.218404652936547 3774 29949 SGTC_2451 5856223 45.7 µM -0.778032482325066 0.236347670859287 no 2629 0.21827493211082 3778 2179896 SGTC_1147 3809-1045 12.3 µM -0.778727209292889 0.236146079014386 no 2630 0.218070212194518 3783 325925 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.779666966648159 0.235873536455048 no 2631 0.217793463705831 3867 688801 SGTC_1334 1486-0610 236 µM -0.779698292106728 0.235864454628372 no 2632 0.217784242183782 3872 3742339 SGTC_2657 nystatin 74.44 µM -0.780449822343487 0.23564662998377 no 2633 0.217563075833672 3830 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1175 0741-0056 27.6 µM -0.780497056187574 0.235632943362883 no 2634 0.217549179809848 3875 765927 SGTC_3239 9133757 49.47 µM -0.780917984472263 0.235510993282449 no 2635 0.217425366876835 3806 17036923 SGTC_271 rotenone 740 µM -0.781447275401029 0.235357698139826 no 2636 0.217269737630562 3805 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1089 terbinafine 2.25 µM -0.782826901172953 0.234958384963323 no 2637 0.216864384025467 3806 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_507 nimesulide 162 µM -0.783272398746536 0.234829521991268 no 2638 0.216733583966893 3832 4495 A COX2 inhibitor. SGTC_1363 1636-0063 10.4 µM -0.783362987309971 0.234803323460385 no 2639 0.216706992346689 3808 6072185 SGTC_2589 lobaric acid 100 µM -0.783419870993638 0.234786873325006 no 2640 0.216690295515595 3830 73157 A novel microtubule depolymerizer. SGTC_374 0880-0231 82.3 µM -0.784670202191183 0.234425452251212 no 2641 0.216323478956089 3754 6833587 SGTC_2013 4024628 200 µM -0.785040650666665 0.234318429460265 no 2642 0.216214867508564 3828 5230760 SGTC_2019 4016004 108 µM -0.78523667202541 0.234261809712331 no 2643 0.216157408963413 3836 45595336 SGTC_328 k915-0120 63.5 µM -0.786622808427055 0.233861647639569 no 2644 0.215751351678012 3817 6624543 SGTC_1951 sophoraflavanone G 9.2 µM -0.786680511154193 0.233844997723884 no 2645 0.21573445772942 3822 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1232 0279-0259 161 µM -0.788419817227753 0.233343435605577 no 2646 0.215225591438279 3826 1560000 SGTC_2935 9038016 29.96 µM -0.788779791241319 0.233239704829842 no 2647 0.215120361432734 3820 6463195 SGTC_2878 9043973 25.97 µM -0.789789914547265 0.232948762552452 no 2648 0.21482523500039 3912 6465167 SGTC_3020 9089140 49.47 µM -0.79155447101971 0.232441007506657 no 2649 0.21431025152819 3881 17217859 SGTC_1688 st021091 57.6 µM -0.792036312813053 0.232302463525283 no 2650 0.214169751551559 3847 3656366 SGTC_1970 st070122 35.8 µM -0.792518989078221 0.232163725682752 no 2651 0.214029062000756 3818 102928 SGTC_2321 7390090 138.78 µM -0.793178007703692 0.231974375437968 no 2652 0.213837059405919 3833 649046 SGTC_964 1287-0107 19.4 µM -0.793301281405506 0.231938965797994 no 2653 0.213801155215949 3844 51516812 YPR165W RHO1 SGTC_1887 st057648 70.8 µM -0.793934979447281 0.231756987307401 no 2654 0.213616642356805 3858 688672 SGTC_210 3551-0445 56.827 µM -0.794271659213841 0.231660335653124 no 2655 0.213518649591243 3830 2865180 YOR207C RET1 SGTC_1305 1181-0477 144 µM -0.794378770309668 0.231629591665207 no 2656 0.213487479726083 3844 6252086 SGTC_2686 alizarin 95.37 µM -0.795653881168902 0.231263772617481 no 2657 0.213116619825435 3841 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_761 k216-0224 480 µM -0.796052285453218 0.23114953974942 no 2658 0.213000822938841 3826 1340404 SGTC_3043 9092303 49.47 µM -0.796888845108315 0.230909778841999 no 2659 0.212757794952106 3838 25236084 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.797281459189424 0.230797302174979 no 2660 0.212643792923609 3835 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_39 0986-0283 58.349 µM -0.798315991123881 0.230501074516877 no 2661 0.212343570259268 3902 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1369 1866-0067 208 µM -0.798347991771848 0.230491914847668 no 2662 0.21233428757615 3818 3531355 SGTC_991 3996-0057 64.7 µM -0.79849492834256 0.230449859236746 no 2663 0.212291667557919 3882 715343 SGTC_1483 3453-0561 55.9 µM -0.798621681673977 0.230413583840103 no 2664 0.2122549058518 3840 4546991 SGTC_2287 7945887 168.79 µM -0.800287555962203 0.229937125895551 no 2665 0.211772105632269 3865 1245853 SGTC_1860 st056228 74.6 µM -0.801361174689039 0.229630351869918 no 2666 0.211461292513709 3809 688679 SGTC_1146 3579-1023 7 µM -0.805013133338691 0.228588565466145 no 2667 0.210406050531757 3902 X1146 SGTC_94 0334-0113 514.748 µM -0.806935364844999 0.228041282737883 no 2668 0.209851861300685 3860 6795178 SGTC_1789 tunicamycin 25 nM -0.807261008184278 0.227948641164047 no 2669 0.209758061713491 3781 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.807923740589136 0.22776016725201 no 2670 0.2095672418166 3870 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3066 9117245 49.47 µM -0.808660287797395 0.227550804153838 no 2671 0.209355288339952 3911 17176980 SGTC_2174 5790901 200 µM -0.809061911561815 0.227436688515724 no 2672 0.20923976771718 3893 786020 SGTC_1632 st005650 90 µM -0.810016815160697 0.227165495818592 no 2673 0.208965255750327 3894 2759605 SGTC_1244 0416-0015 52.5 µM -0.812272870756999 0.226525500427475 no 2674 0.208317536936957 3840 96201 SGTC_1177 0983-0204 23.6 µM -0.812748569868179 0.226390684689495 no 2675 0.208181113962827 3898 766818 SGTC_2448 5185112 27.17 µM -0.813795783419794 0.226094058359857 no 2676 0.207880975536299 3866 5718189 SGTC_1807 st050092 58.9 µM -0.81490004967837 0.225781509756556 no 2677 0.207564762371254 3878 5008496 SGTC_1716 st033144 30.6155 µM -0.815183088227595 0.225701438638616 no 2678 0.207483758399228 3827 674617 SGTC_551 k048-0028 34.9 µM -0.815672826356186 0.225562930519797 no 2679 0.207343642363847 3830 6836383 SGTC_3231 9132313 49.47 µM -0.817760523023126 0.224973026429155 no 2680 0.206746971880413 3847 4905967 SGTC_2896 9052656 71.43 µM -0.818172531752771 0.224856711743364 no 2681 0.206629338671763 3787 6469436 SGTC_2942 9052777 62.25 µM -0.818270301887061 0.224829115143721 no 2682 0.206601429999391 3940 6469503 SGTC_1964 st076914 61 µM -0.818508287612033 0.224761949315809 no 2683 0.206533505849495 3898 24208661 SGTC_140 0062-0056 502.533 µM -0.81896027949479 0.224634416655746 no 2684 0.206404538048099 3818 3758964 SGTC_1385 3091-4834 14.1 µM -0.820532427195826 0.224191144057455 no 2685 0.205956325607816 3854 4072814 SGTC_1748 st037455 53.6035 µM -0.820906786868698 0.224085665293965 no 2686 0.205849682464044 3884 580690 SGTC_468 gf-109203x 121 µM -0.821064924897655 0.224041117138551 no 2687 0.205804643822092 3813 2396 A protein kinase C inhibitor. SGTC_1643 st009866 20.2 µM -0.823747897355601 0.223286079541358 no 2688 0.205041408956766 3832 3156273 YOR207C RET1 SGTC_2334 9017922 200 µM -0.823780016715566 0.22327704934619 no 2689 0.205032282049429 3936 3163164 SGTC_2836 9010338 19.48 µM -0.824132943468974 0.223177839469986 no 2690 0.204932011717031 3875 2994051 SGTC_540 1187-0821 17.3 µM -0.824422377593666 0.223096496494412 no 2691 0.204849802094518 3822 847520 SGTC_860 0443-0016 25.1 µM -0.824707291668977 0.223016440330592 no 2692 0.20476889548447 3894 5337942 SGTC_639 0833-0042 114 µM -0.825033660139436 0.222924756272246 no 2693 0.20467624049215 3850 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2069 5228469 200 µM -0.826102018971886 0.222624781081996 no 2694 0.204373111245449 3855 2835210 SGTC_1213 1315-0166 115 µM -0.826937688482348 0.222390301182597 no 2695 0.204136190154578 3957 768401 SGTC_1727 st034309 9.9045 µM -0.827357149718962 0.22227265798029 no 2696 0.204017330175268 3994 870305 SGTC_1206 3978-0017 132 µM -0.828464501769266 0.221962257769019 no 2697 0.203703745259485 3973 3873677 SGTC_2842 9000675 19.48 µM -0.830092838714404 0.221506270939057 no 2698 0.203243147846966 3926 2989072 SGTC_85 0868-0259 160.055 µM -0.831772448484139 0.221036487605922 no 2699 0.202768699067066 3839 83173 SGTC_891 0929-0073 133 µM -0.833120166490626 0.220659946381915 no 2700 0.20238848056545 3945 5603632 SGTC_2325 6158266 200 µM -0.833429333984489 0.220573619392373 no 2701 0.202301318322604 3928 3623240 SGTC_3135 9127742 49.47 µM -0.833669857074518 0.220506472953652 no 2702 0.202233524227701 3960 3643468 SGTC_654 1124-0271 80.9 µM -0.835805011493584 0.219910919114586 no 2703 0.201632303359866 3886 5403748 SGTC_1575 cyproterone acetate 48 µM -0.838409662233752 0.21918566109953 no 2704 0.200900332350991 3910 9880 An androgen receptor antagonist and liver toxin. SGTC_2219 9098279 200 µM -0.838788006210637 0.219080426727261 no 2705 0.200794141151694 3840 902349 SGTC_645 0845-0943 5.41 µM -0.83899420697712 0.219023085310929 no 2706 0.200736280207925 3888 1885106 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.841431486160083 0.218345967902302 no 2707 0.200053126291671 3879 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_382 3229-0966 23.2 µM -0.842526129614321 0.218042250269212 no 2708 0.199746760044493 3917 5722370 SGTC_3147 9097027 49.47 µM -0.843481007929253 0.217777510596577 no 2709 0.199479741566822 3914 25236841 SGTC_1981 st071826 47 µM -0.84503179659142 0.217347950333158 no 2710 0.199046543134432 3924 11838600 SGTC_3189 9110682 49.47 µM -0.84816329341747 0.216482035363642 no 2711 0.198173518269276 3999 17122418 SGTC_1634 st006576 41 µM -0.848381680413223 0.216421722000506 no 2712 0.1981127208672 3872 3915356 SGTC_942 3253-1115 227 µM -0.849557453476315 0.216097168240323 no 2713 0.197785587504687 3965 46497897 SGTC_772 k072-0172 35.3 µM -0.8503940390492 0.215866413623312 no 2714 0.197553024567027 3948 5861980 SGTC_1169 aniline yellow 25.8 µM -0.850782873742416 0.215759210339553 no 2715 0.197444988469882 3848 6051 A DNA damaging agent. SGTC_2684 capsaicin 100 µM -0.851887989748178 0.215454693973092 no 2716 0.197138131717171 3926 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2979 9012552 45.46 µM -0.852356481586521 0.215325675631331 no 2717 0.197008133076668 3943 17100905 SGTC_1041 0206-0046 107 µM -0.855350632720242 0.21450217342118 no 2718 0.196178532410736 3940 50494 SGTC_176 1486-1328 72.834 µM -0.858657309468872 0.213594846358584 no 2719 0.195264804895924 3976 22310231 SGTC_3280 9140961 49.47 µM -0.859218445262424 0.213441097182924 no 2720 0.195110004385689 3955 4901226 SGTC_571 k831-0106 44.2 µM -0.861497251955879 0.212817375670301 no 2721 0.194482117016708 3820 4783639 SGTC_3197 9113331 49.47 µM -0.86186209272104 0.21271761570907 no 2722 0.19438170553754 3915 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_707 0865-0008 204 µM -0.862321802224912 0.212591954269261 no 2723 0.194255229232554 3920 723043 SGTC_2994 9053520 71.4286 µM -0.86261409724941 0.212512078073417 no 2724 0.194174838441235 3979 4647384 SGTC_135 0933-0004 26.348 µM -0.863235204373831 0.212342404786149 no 2725 0.194004080747425 3915 21230617 YGL099W LSG1 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.863579534412355 0.212248375245259 no 2726 0.193909455347846 3944 115019 SGTC_1628 st004252 77.7 µM -0.864545988979709 0.21198458618681 no 2727 0.193644014102248 3952 692968 SGTC_144 4161-2749 112.381 µM -0.865715295507661 0.211665686156636 no 2728 0.193323155004382 3827 797501 YMR168C CEP3 SGTC_1722 st034304 3.6505 µM -0.86644680268311 0.211466328153824 no 2729 0.193122593631501 3924 4036148 YLR033W RSC58 SGTC_2319 6033012 152.6 µM -0.8672841905424 0.211238249469593 no 2730 0.19289315836643 3888 847246 SGTC_2907 7721985 69.9 µM -0.868893257842404 0.210800393834593 no 2731 0.192452758810279 3973 3267881 SGTC_1740 st038286 13.222 µM -0.874883618082714 0.209174997506762 no 2732 0.190818616746964 3996 716786 SGTC_525 k781-2675 26.7 µM -0.875603943474635 0.208980045983747 no 2733 0.190622690427591 3916 3651118 YDL195W SEC31 SGTC_1314 1222-0010 41.1 µM -0.876265375364557 0.208801127903251 no 2734 0.190442891759563 3939 3526027 SGTC_920 mycophenolic acid 780.421 nM -0.877054253597095 0.208587853510392 no 2735 0.190228585261737 3964 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_752 1896-0090 130 µM -0.877472276803978 0.208474892397009 no 2736 0.1901150852436 3911 772567 SGTC_1963 st076565 50.3 µM -0.879206215384863 0.208006720865502 no 2737 0.189644737519916 3957 4914280 SGTC_1655 st012546 55.1 µM -0.879566860975916 0.207909422898087 no 2738 0.189546998891606 3921 720985 YLR208W SEC13 SGTC_727 3032-0951 202 µM -0.880552617339551 0.207643614498692 no 2739 0.189280007046893 3952 3652836 SGTC_674 0498-0004 451 µM -0.880769285010617 0.207585217165518 no 2740 0.189221353718664 3944 4231473 SGTC_2802 7925815 54.55 µM -0.880773936251022 0.207583963646811 no 2741 0.18922009472076 3919 1262923 SGTC_280 3448-3607 3.04 µM -0.881791387613453 0.207309865964948 no 2742 0.188944814928408 3925 626179 SGTC_2118 5526350 200 µM -0.882125133360269 0.207220002712462 no 2743 0.188854571051849 4002 743594 SGTC_3077 9117319 49.47 µM -0.88213263584331 0.207217982884015 no 2744 0.188852542707598 3903 17154678 SGTC_3044 9093193 49.47 µM -0.882362918330309 0.207155991590938 no 2745 0.18879029089482 3966 25236277 SGTC_2211 7117706 200 µM -0.884497107757346 0.206581996885381 no 2746 0.188213961521893 3873 822771 SGTC_2414 st077232 92.9 µM -0.884620349902877 0.20654887944741 no 2747 0.188180713659463 3921 729801 SGTC_497 capsazepine 133 µM -0.885554841471842 0.206297866668579 no 2748 0.187928727531615 3934 2733484 A calcium channel blocker. SGTC_679 0422-0091 41.4 µM -0.885668433691297 0.206267367113067 no 2749 0.187898111539407 3927 627384 YHR062C RPP1 SGTC_1622 st003707 19.4 µM -0.887109840892431 0.205880580896396 no 2750 0.187509883174709 3983 10140899 SGTC_1943 st076331 65.2 µM -0.889561578703375 0.205223672505885 no 2751 0.186850672211183 3982 24208415 SGTC_123 0083-0120 66.675 µM -0.890008276004221 0.205104120554711 no 2752 0.186730721125245 3936 16001701 SGTC_327 1273-0057 3.96 µM -0.893825382100386 0.204084217436947 no 2753 0.185707663211799 3849 3108138 SGTC_220 paclitaxel 373.376 µM -0.893950430179429 0.204050856682829 no 2754 0.185674206849626 3914 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3110 9122132 49.47 µM -0.897350500750009 0.203145019880955 no 2755 0.184765958403904 4073 918317 SGTC_1755 st041960 45.185 µM -0.899541601223117 0.202562547406574 no 2756 0.184182123659602 4036 2257073 SGTC_2126 5251174 33.877 µM -0.899564358474521 0.202556502962391 no 2757 0.184176065854605 3983 790722 SGTC_749 1000-0129 128 µM -0.899716680469778 0.202516048225299 no 2758 0.184135522105961 4029 708470 SGTC_2868 9035608 32.47 µM -0.899960892948721 0.202451198654108 no 2759 0.184070531339394 3936 6462614 SGTC_3225 9130819 49.47 µM -0.900145659722821 0.202402142885315 no 2760 0.184021369983498 3913 4547121 SGTC_2277 7947813 106.88 µM -0.900506057218454 0.202306477435614 no 2761 0.18392550165068 4057 1246798 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.900773611631951 0.202235474144472 no 2762 0.183854350366652 3968 364106 SGTC_1519 esterone 74 µM -0.901500998184919 0.202042516483345 no 2763 0.183661001668009 3948 698 A steroid. SGTC_1161 k007-0610 110 µM -0.904175817915596 0.201333901098595 no 2764 0.182951090332401 3950 5843850 SGTC_2585 alliin 100 µM -0.904310287492688 0.20129831668438 no 2765 0.182915446657881 4033 87310 A garlic compound which reacts with lipids. SGTC_2741 miltefosine 3.04 µM -0.904942604550561 0.201131038445927 no 2766 0.182747897313274 3945 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1937 st074714 47.2 µM -0.905445228671046 0.200998129708504 no 2767 0.182614781960431 3930 17250970 SGTC_929 2805-0021 398 µM -0.905694607167932 0.200932206191062 no 2768 0.182548758850028 4049 3098024 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.907026995521786 0.200580207530007 no 2769 0.182196260878383 3957 6312947 SGTC_1136 pergolide 1.05886 µM -0.907046377464012 0.20057508982146 no 2770 0.182191136314061 3962 47811 A dopamine receptor agonist. SGTC_1984 st072354 53.1 µM -0.907137604516829 0.200551002810341 no 2771 0.182167017191056 3859 5762938 SGTC_1118 chelidonine 707.474 nM -0.907498722849378 0.200455672469359 no 2772 0.182071562276572 3948 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_3134 9127454 49.47 µM -0.907767927922555 0.200384623692662 no 2773 0.182000423271383 4031 24262820 SGTC_2051 5263410 176 µM -0.909011332871058 0.200056659799848 no 2774 0.181672071858085 4004 227584 SGTC_1607 st000305 50.6 µM -0.909544126518899 0.19991622750445 no 2775 0.18153148821068 3993 5457690 SGTC_612 0302-0167 22.4 µM -0.912850015853984 0.199046196037328 no 2776 0.180660714497349 4001 235821 SGTC_2850 9015429 58.44 µM -0.913700704216816 0.198822684693475 no 2777 0.180437066946156 4041 6457570 SGTC_810 3825-7150 143 µM -0.914045019706781 0.19873226167075 no 2778 0.180346595162333 4056 22330411 YGL099W LSG1 SGTC_3268 9137683 49.47 µM -0.914469029183856 0.198620943745291 no 2779 0.180235222230217 4023 1953228 SGTC_2152 5568786 200 µM -0.91462538933965 0.198579903004148 no 2780 0.180194162608239 3956 5399883 SGTC_2486 5283202 22.39 µM -0.914667859428982 0.198568756521164 no 2781 0.180183011127501 4042 1377751 SGTC_2962 9082311 13.18 µM -0.915726742808089 0.198290969407597 no 2782 0.17990511743898 3987 16459453 SGTC_3097 9117246 49.47 µM -0.916713365573929 0.198032350317011 no 2783 0.179646430233754 4008 16423892 SGTC_1479 0549-0158 134 µM -0.916854207076985 0.197995448774115 no 2784 0.179609521420004 4019 5440202 SGTC_1758 st042942 75.2445 µM -0.9178811197585 0.197726515406797 no 2785 0.179340553550475 3911 669317 SGTC_1767 st044992 70.3 µM -0.919037344542992 0.197423981434795 no 2786 0.179038019674437 4035 9600693 SGTC_1654 st012436 41.8 µM -0.920348055068996 0.197081363964 no 2787 0.178695452153347 3935 4323132 SGTC_82 0054-0107 293.755 µM -0.920483445175086 0.197045993739745 no 2788 0.178660090104583 3953 3104697 SGTC_1258 0671-0043 57.1 µM -0.922011850782737 0.196646969300554 no 2789 0.178261197099936 4026 4298767 SGTC_463 ikarugamyin 104 µM -0.923680855355524 0.196211797907325 no 2790 0.17782625130352 4065 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1565 sinapyl alcohol 95.1 µM -0.924864449453072 0.195903545199622 no 2791 0.177518210447391 4053 5280507 A phenol propionate derived from cinnamic acid. SGTC_428 3448-4153 16.5 µM -0.925619539116443 0.195707044881086 no 2792 0.177321867749514 3970 3834874 SGTC_1907 st060210 83.7 µM -0.926025520789185 0.195601443952396 no 2793 0.177216358797251 4050 688793 SGTC_883 0850-0245 24.6 µM -0.926037261201421 0.195598390638622 no 2794 0.177213308218504 4078 6823229 YPR165W RHO1 SGTC_1619 st003326 88.7 µM -0.926148656620989 0.195569421616366 no 2795 0.177184365357039 3986 2849032 SGTC_3228 9131799 49.47 µM -0.9269534190893 0.195360215893916 no 2796 0.176975359930995 3999 17015818 SGTC_2970 9090938 41.86 µM -0.929247225311085 0.19476466539068 no 2797 0.176380489181189 4085 17217104 SGTC_1856 st057054 55.7 µM -0.929271410106122 0.194758392080335 no 2798 0.176374223895686 4043 1266018 SGTC_317 4495-0002 170 µM -0.930426643904244 0.194458878382812 no 2799 0.176075114350592 4036 15991618 SGTC_980 1473-0395 201 µM -0.930435538231131 0.194456573467888 no 2800 0.176072812705547 3891 768876 SGTC_1571 st070080 73.4 µM -0.931093962933802 0.1942859925846 no 2801 0.175902480595154 4057 4315245 SGTC_1509 1326-1131 80 µM -0.935982549618357 0.193022337550177 no 2802 0.174641086238937 3928 768313 SGTC_1273 0849-0096 14.1 µM -0.93690314214281 0.192784935551619 no 2803 0.17440419138896 4035 5286025 SGTC_671 0560-0003 407 µM -0.939650982581143 0.192077385237093 no 2804 0.173698307971146 3913 3238678 SGTC_3210 9128157 49.47 µM -0.942216053995058 0.191418332697622 no 2805 0.173041018122358 4075 17590849 SGTC_2256 7954252 200 µM -0.942610971123406 0.191316988528062 no 2806 0.172939963034451 4054 2972920 SGTC_2618 avocadyne 43.43 µM -0.942716491872865 0.191289915218582 no 2807 0.172912967765616 3938 3015189 SGTC_799 1310-0557 151 µM -0.942923631515739 0.191236776523163 no 2808 0.172859983245303 4093 5354492 SGTC_2606 farnesol 9.78 µM -0.943657255011931 0.191048648758606 no 2809 0.17267241195592 4079 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_688 0527-0193 473 µM -0.944577297761475 0.190812876799297 no 2810 0.172437360868678 4047 4007154 SGTC_380 3970-0968 6 µM -0.946743997275062 0.190258339834932 no 2811 0.171884622518612 3913 2891601 SGTC_2922 7999257 32.47 µM -0.947000096623853 0.19019286021525 no 2812 0.171819364849063 3988 2988377 SGTC_170 4197-0004 226 µM -0.947726758902805 0.190007142205841 no 2813 0.171634287366629 4059 218692 SGTC_3274 9138298 49.47 µM -0.949258830484888 0.18961594569426 no 2814 0.171244493426833 3991 17015756 SGTC_3296 9122258 64.045 µM -0.949944496236612 0.18944102959573 no 2815 0.171070227914007 4032 4730474 SGTC_1109 tnp00067 928.257 nM -0.950078936603859 0.189406744963363 no 2816 0.17103607250133 4023 676295 SGTC_1600 coumarin 106 71.1 µM -0.950221549682947 0.189370380321664 no 2817 0.170999845528509 4097 100336 A hepatotoxic, DNA x-linker. SGTC_2261 9010538 184.68 µM -0.952112488159487 0.188888619790565 no 2818 0.170519968137005 4044 6457250 SGTC_2762 leflunomide 42.06 µM -0.95338535758618 0.188564752364592 no 2819 0.170197428760165 3996 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1254 0550-0035 264 µM -0.95394718623239 0.188421910314546 no 2820 0.170055188345084 4109 15121435 SGTC_2425 5628681 7.85 µM -0.954756115482698 0.18821636146267 no 2821 0.16985052234397 4109 5714958 SGTC_359 0081-0058 15.9 µM -0.958177934558562 0.187348409003272 no 2822 0.168986520915222 4132 3494159 SGTC_932 2857-0803 154 µM -0.958901191003749 0.187165270569512 no 2823 0.168804262367011 4114 674898 SGTC_1663 st014140 55.4 µM -0.962530832115893 0.186247868732457 no 2824 0.167891511607842 4118 4207120 SGTC_2330 7979373 200 µM -0.96520467837332 0.185573832312873 no 2825 0.167221152077096 3992 1863007 SGTC_1077 5-fluorocytosine 377 nM -0.966691295255736 0.185199734183737 no 2826 0.166849189975134 4079 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3053 9095903 49.47 µM -0.967056523313604 0.185107898473146 no 2827 0.166757889055269 4140 17174018 SGTC_662 k832-1615 104 µM -0.968825019811841 0.184663614535972 no 2828 0.166316250491504 4079 5878478 SGTC_1266 0828-0227 32.9 µM -0.969003347602971 0.18461885162947 no 2829 0.166271759465812 4062 3913820 SGTC_1347 1493-0251 600 nM -0.969782466477205 0.184423360443305 no 2830 0.166077467152652 4105 3986378 SGTC_1037 k284-1091 78.7 µM -0.973325572953285 0.183535973662775 no 2831 0.165195758224787 4036 3334711 SGTC_1332 1480-0653 17.5 µM -0.974658020659058 0.183202945933007 no 2832 0.164864961400519 4063 5749438 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.976781117318206 0.182673085191065 no 2833 0.164338763115559 4076 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2079 5212404 121 µM -0.979509378565065 0.181993600092119 no 2834 0.163664178464504 4030 758462 SGTC_1969 st069479 40.1 µM -0.979935162117094 0.181887699629742 no 2835 0.163559062440953 4085 3895485 SGTC_2184 6075246 200 µM -0.980209014329356 0.181819607749311 no 2836 0.163491477890916 4071 2267320 SGTC_534 k292-0788 63.4 µM -0.980895661173083 0.181648946827086 no 2837 0.163322098667462 4103 4146317 SGTC_2726 cimetidine 79.27 µM -0.983702914990556 0.180952268053627 no 2838 0.162630803076591 4051 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_182 3448-4371 550.524 µM -0.98525745540394 0.180567197649506 no 2839 0.162248812449076 3963 3491403 SGTC_3242 9133940 49.47 µM -0.985448901812704 0.180519810619596 no 2840 0.162201809565942 4097 17248444 SGTC_617 3770-0098 35 µM -0.98883911593101 0.179681953477959 no 2841 0.161370931404294 4001 5962639 SGTC_2037 5169046 200 µM -0.989405179838516 0.179542294935314 no 2842 0.16123247062031 4144 5718022 SGTC_2539 epi(13)torulosol 80 µM -0.992921142721816 0.178676369831614 no 2843 0.160374192708286 4117 6708597 SGTC_2897 9048598 12.99 µM -0.993039164725044 0.178647348601192 no 2844 0.1603454343701 4063 6467404 SGTC_2049 5262831 67.185 µM -0.993779256014329 0.178465430209333 no 2845 0.160165173680382 4088 763417 SGTC_1692 fluoroquinolonic acid 71 µM -0.993919455266444 0.178430981635812 no 2846 0.160131040913242 4126 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1847 st056231 15 µM -0.994170683204818 0.178369262512959 no 2847 0.160069889112174 4083 5393180 SGTC_1745 st081495 74 µM -0.994545792259797 0.178277134576911 no 2848 0.15997861163095 3971 13842402 YBL026W LSM2 SGTC_2245 6637752 200 µM -0.994574461778134 0.178270094488889 no 2849 0.159971636709798 4149 681890 SGTC_2649 anisomycin 9.56 µM -0.99513300622757 0.178132973249557 no 2850 0.159835789785778 4088 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3002 9075603 71.4286 µM -0.995738576956585 0.177984382317894 no 2851 0.159688590607171 4017 20105405 SGTC_2635 hydroquinidine 100 µM -0.997012653995261 0.177672013028443 no 2852 0.15937918390895 4010 442912 An experimental heart treatment. SGTC_812 4251-0442 148 µM -1.00060820130239 0.176792348885604 no 2853 0.158508131775214 4130 5723007 SGTC_836 0330-0104 1.35 µM -1.00086113044377 0.176730572640208 no 2854 0.15844697529023 4104 46494820 SGTC_2546 rhodinyl acetate 100 µM -1.00170219837624 0.176525245601056 no 2855 0.158243722309497 4043 6708682 SGTC_3346 9158254 43.5805 µM -1.00802640219591 0.174986175149405 no 2856 0.156720893749267 4097 17639500 SGTC_480 am 92016 50 µM -1.01192119498866 0.174042580321628 no 2857 0.155787867158088 4077 2129 K+ channel blocker. SGTC_886 0866-0150 153 µM -1.01627124365993 0.172992521864536 no 2858 0.154750119187882 4173 271463 SGTC_2934 9036370 36.88 µM -1.01776826163216 0.172632092104767 no 2859 0.15439404921264 4101 6462800 SGTC_1827 berberine 7.24 µM -1.01824288624702 0.172517919071881 no 2860 0.154281271583073 4040 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1626 st003712 1.76 µM -1.01826362330117 0.17251293178073 no 2861 0.154276345403384 4141 24207035 SGTC_943 3253-1379 105 µM -1.01847765239165 0.172461462850499 no 2862 0.154225507915573 4138 668464 SGTC_1761 st044296 37 µM -1.02050757022917 0.171973802671752 no 2863 0.153743900410072 4089 1826700 SGTC_2357 9067248 200 µM -1.02057775497158 0.171956957501478 no 2864 0.153727266577193 4103 9150235 SGTC_2437 5741531 144.16 µM -1.02183048024468 0.171656465807633 no 2865 0.153430570228674 4145 2262990 SGTC_3089 9117425 49.47 µM -1.02189294196148 0.171641491876886 no 2866 0.153415786685323 4121 9401657 SGTC_3171 9103192 49.47 µM -1.02369224300865 0.171210504201875 no 2867 0.152990330193568 4171 13018434 SGTC_1817 st052116 64.4 µM -1.02470582102122 0.170968026209572 no 2868 0.152751007798409 4138 4361398 SGTC_72 0744-0168 198.391 µM -1.02487341623085 0.170927953629956 no 2869 0.152711459756207 4011 677577 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.02734264042053 0.170338250390777 no 2870 0.152129575285334 4127 688669 SGTC_1046 2001-0062 216 µM -1.02780076580155 0.170228983803575 no 2871 0.152021777989934 4024 739778 SGTC_1087 pterostilbene 9.05 µM -1.02818340873534 0.170137754813368 no 2872 0.151931780672107 4168 5281727 Similar to reservatol, lowers cholesterol. SGTC_3087 9117406 49.47 µM -1.02847360362036 0.170068588003324 no 2873 0.151863550667164 4139 42546093 SGTC_655 k060-0012 42 µM -1.02851064221399 0.170059761297188 no 2874 0.151854843696911 4105 5994525 SGTC_2216 7189485 200 µM -1.03103271237721 0.169459414868669 no 2875 0.151262739891946 4123 731273 SGTC_400 oxethazaine 37.5 µM -1.03269236608031 0.169065098467528 no 2876 0.150873943586031 4132 4621 A local anesthetic. SGTC_2889 9059656 51.95 µM -1.03276668801648 0.169047454146803 no 2877 0.150856548243935 4204 3949838 SGTC_549 1661-1316 519 µM -1.03810395281197 0.167783458938609 no 2878 0.149610830690308 4161 2857282 SGTC_1395 3486-0190 4.35 µM -1.04059685858225 0.167195168109235 no 2879 0.149031344901227 4124 6748079 SGTC_1392 3455-1037 33.9 µM -1.04141597572661 0.167002158530969 no 2880 0.148841265593173 4137 981132 SGTC_2992 9074591 71.4286 µM -1.04238432874795 0.166774169738966 no 2881 0.148616764580316 4095 17741321 SGTC_1068 loratadine 26.9 µM -1.04238604742242 0.166773765273286 no 2882 0.148616366327649 4165 3957 A H1 histamine antagonist. SGTC_3115 9123671 49.47 µM -1.04279527501092 0.166677477376084 no 2883 0.148521560083243 4253 3286988 SGTC_890 0929-0006 47.2 µM -1.04432464802703 0.16631794607813 no 2884 0.148167606453251 4102 1378169 SGTC_1920 st075728 45.7 µM -1.04644675337384 0.165819903059414 no 2885 0.14767740824517 4115 3400306 SGTC_2371 9071574 200 µM -1.04777158378732 0.165509464119503 no 2886 0.147371928825959 4147 45596039 SGTC_1115 galangin 695.678 nM -1.05132215213542 0.164679337514234 no 2887 0.146555328176812 4209 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_766 1391-0721 126 µM -1.05379907986231 0.164101829373768 no 2888 0.145987457437844 4183 1020919 YIL115C NUP159 SGTC_1011 4112-3381 17.4 µM -1.05389558201918 0.164079356030927 no 2889 0.145965362915338 4222 2877139 SGTC_438 sphingosine 6.67 µM -1.05431828044107 0.163980941895945 no 2890 0.1458686110385 4085 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2913 7966556 36.57 µM -1.05469707261274 0.163892782713271 no 2891 0.145781945533145 4019 2976516 SGTC_1741 st038134 10.228 µM -1.05689271305797 0.163382380568311 no 2892 0.145280277245594 4208 1272587 SGTC_126 0417-1624 672.48 µM -1.05838032912958 0.163037154329582 no 2893 0.144941041887529 4214 41912 YDL195W SEC31 SGTC_1245 0418-0076 17.2 µM -1.05863749013516 0.16297752391311 no 2894 0.144882453103418 4194 6790114 SGTC_500 h-89 112 µM -1.05900052590735 0.162893367427188 no 2895 0.144799770105207 4179 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2370 9071495 200 µM -1.06162497211705 0.1622858267755 no 2896 0.144202986173387 4159 21791103 SGTC_1833 st055984 71 µM -1.06226433159217 0.162138043342908 no 2897 0.144057851063304 4164 676288 SGTC_1368 1852-0141 284 µM -1.06292205181309 0.161986107428988 no 2898 0.143908650872245 4173 2838987 SGTC_743 1275-0778 158 µM -1.06327320725128 0.16190502715261 no 2899 0.143829035901346 4142 2849257 YMR203W TOM40 SGTC_1467 k284-1082 293 µM -1.06364702270165 0.161818743836524 no 2900 0.143744316046588 4121 3334705 SGTC_510 ag-490 170 µM -1.06465440976858 0.161586370018387 no 2901 0.143516174034722 4271 5328779 SGTC_2603 homopterocarpin 100 µM -1.06522391634145 0.161455098324943 no 2902 0.143387306620073 4148 101795 A weak amylase inhibitor. SGTC_3022 9087993 49.47 µM -1.06548808932948 0.161394229868962 no 2903 0.143327556338277 4216 17173644 SGTC_2805 7950783 58.44 µM -1.06553413706653 0.161383621479326 no 2904 0.143317143045716 4183 1178958 YDL195W SEC31 SGTC_2714 st079313 56.9 µM -1.0666130089253 0.161135203187382 no 2905 0.143073311831515 4139 2939799 SGTC_349 k015-0014 24 µM -1.06680093159845 0.161091958118728 no 2906 0.143030868909918 4145 2196908 SGTC_2345 9052315 157.45 µM -1.06766222248225 0.160893853378983 no 2907 0.142836452530824 4212 6469265 SGTC_1604 st002052 72.4 µM -1.06802508200564 0.160810440021584 no 2908 0.142754598937333 4240 6254834 YHR062C RPP1 SGTC_892 0929-0076 29 µM -1.06973429375125 0.160417909946564 no 2909 0.142369462687905 4135 5751038 SGTC_1405 3909-7894 12 µM -1.07290156628018 0.15969218439763 no 2910 0.141657641620147 4165 7104060 SGTC_3352 9151559 45.5865 µM -1.07367791347918 0.159514626247988 no 2911 0.14148353186462 4169 17159339 SGTC_3121 9125696 49.47 µM -1.0738837691261 0.159467566745085 no 2912 0.141437389384675 4272 1235365 SGTC_2723 salbutamol 83.58 µM -1.07525157399333 0.159155111402432 no 2913 0.141131055361515 4188 9884233 β2-adrenoceptor agonist SGTC_1336 1486-0901 104 µM -1.07629737036483 0.158916484973035 no 2914 0.140897142170345 4191 5006114 SGTC_2364 9055074 200 µM -1.07676987745544 0.158808746775283 no 2915 0.140791542853712 4191 6470630 SGTC_2673 kobusone 100 µM -1.07949019754845 0.158189407402389 no 2916 0.140184630637448 4254 6710676 An epoxy ketone and protein crosslinker. SGTC_1665 st014639 11.4 µM -1.08111345057007 0.157820595109857 no 2917 0.139823325476493 4223 981133 YIL048W NEO1 SGTC_2189 6047310 154.431 µM -1.0818158718725 0.157661176203962 no 2918 0.139667176280706 4159 711535 SGTC_1035 k081-0041 55.2 µM -1.08253396435079 0.157498310023545 no 2919 0.139507665971544 4203 731709 SGTC_2457 5731572 11.68 µM -1.0833184086143 0.157320521403668 no 2920 0.139333558557465 4224 2865357 SGTC_459 nigericin 15.3 µM -1.083642463118 0.157247115317303 no 2921 0.139261677824205 4248 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_160 3453-0671 289.699 µM -1.08591093268416 0.156733883470995 no 2922 0.138759199780072 4222 5322268 SGTC_2222 6885208 172.143 µM -1.09118302824395 0.155545356903607 no 2923 0.137596177140848 4144 609514 SGTC_1983 st071813 46.9 µM -1.09179498359186 0.155407785513317 no 2924 0.137461612233698 4251 11838595 SGTC_1280 0880-0253 10.1 µM -1.09538701332554 0.154601893945427 no 2925 0.136673560575877 4163 6836607 SGTC_1706 st031321 9.9705 µM -1.09655516691578 0.154340408488755 no 2926 0.136417947515974 4214 6103185 SGTC_3094 9117742 49.47 µM -1.09668893385011 0.154310484087761 no 2927 0.136388697781501 4126 17149698 SGTC_1747 st037496 66.6 µM -1.09876830657904 0.153845810313182 no 2928 0.135934569826975 4168 723305 SGTC_1178 0988-0033 191 µM -1.09885677678145 0.153826060593472 no 2929 0.135915271222905 4231 5392207 SGTC_2652 actinonin 100 µM -1.09946346159839 0.153690672012299 no 2930 0.135782981499034 4200 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2234 tolnaftate 200 µM -1.10092853683094 0.15336404928105 no 2931 0.135463880475551 4245 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_145 3737-0113 38.366 µM -1.10305255971285 0.152891338450475 no 2932 0.135002170434082 4150 6849351 SGTC_211 3455-0679 143.504 µM -1.10391696219353 0.152699238683408 no 2933 0.134814580072228 4241 748649 SGTC_1842 st055362 61.2 µM -1.10671184593721 0.152079216155334 no 2934 0.134209266053028 4163 676032 SGTC_3222 9128301 49.47 µM -1.10732011132432 0.151944499205686 no 2935 0.134077776084928 4202 4911358 SGTC_469 w7 172 µM -1.1078527366602 0.151826599926796 no 2936 0.13396271008587 4277 45115570 A P450 inhibitor. SGTC_289 k017-0060 526 µM -1.10807009247846 0.151778504599176 no 2937 0.133915773007564 4171 5512909 SGTC_40 0327-0103 19.753 µM -1.10908657938986 0.151553716232205 no 2938 0.133696416944112 4057 409036 SGTC_484 loperamide 105 µM -1.10951561165076 0.151458905457649 no 2939 0.133603906724139 4215 3955 An opioid-receptor agonist. SGTC_496 calpeptin 138 µM -1.11317161658759 0.15065257418447 no 2940 0.132817365161382 4210 73364 A calpain inhibitor. SGTC_3256 9138902 49.47 µM -1.11363429519376 0.150550734653644 no 2941 0.132718053693089 4293 17228773 SGTC_2683 piperine 63.03 µM -1.11550241357278 0.150140012197377 no 2942 0.132317592373087 4179 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1554 st069299 38.7 µM -1.11728147871968 0.14974956388761 no 2943 0.131936996041041 4179 24207999 SGTC_1641 st009299 47.1 µM -1.11921465336452 0.149326062014561 no 2944 0.131524287776773 4140 4046054 SGTC_2675 theaflavin digallate 100 µM -1.12084052043272 0.148970501866352 no 2945 0.131177876361557 4152 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_3290 9121031 71.43 µM -1.12182075041745 0.148756409330168 no 2946 0.130969330807397 4225 17014854 SGTC_3294 9122953 26.2835 µM -1.12329127245899 0.148435617689955 no 2947 0.130656904620965 4190 16459826 SGTC_517 1365-0151 113 µM -1.12463861171996 0.148142104573907 no 2948 0.130371102439015 4256 768657 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.12474883403936 0.148118110226528 no 2949 0.130347740856662 4275 23847180 SGTC_127 0180-0333 59.125 µM -1.12502420505937 0.148058175947944 no 2950 0.130289388719845 4119 771601 SGTC_68 0986-0284 82.829 µM -1.12665275664859 0.147704054884067 no 2951 0.129944662113649 4264 423278 YIL048W NEO1 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.12821399565668 0.147365103598605 no 2952 0.129614777312379 4226 16486 A toxic proline analog. SGTC_686 1319-0111 510 µM -1.12969229109204 0.147044640512721 no 2953 0.129302953332371 4269 4562600 SGTC_2658 polymyxin b sulfate 77.05 µM -1.13012223525252 0.146951525523721 no 2954 0.129212360816973 4249 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_3038 9091290 49.47 µM -1.13445927298136 0.146014444931065 no 2955 0.12830097405386 4257 25236843 SGTC_2769 toremifene 3.73 µM -1.13546574850679 0.145797556355077 no 2956 0.128090112567147 4272 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_565 1418-0001 44.5 µM -1.13959888445789 0.144909165202797 no 2957 0.127226725159382 4288 2862145 SGTC_1965 Pectolinarigenin 58.4 µM -1.14149735287243 0.144502325596232 no 2958 0.126831506472666 4200 5320438 An anti-inflammatory. SGTC_2011 4012611 177 µM -1.14211200270156 0.144370771923311 no 2959 0.12670373347515 4217 2049887 SGTC_2438 5259590 200 µM -1.14491410636123 0.143772059888028 no 2960 0.126122369958328 4247 1201127 SGTC_1202 1988-0068 29.6 µM -1.14552608420994 0.14364152473012 no 2961 0.125995648298637 4206 2850480 SGTC_2895 9054447 58.44 µM -1.14682725557294 0.14336425017189 no 2962 0.125726511123107 4303 2697450 SGTC_2426 5582046 32.21 µM -1.14728334661931 0.143267144543341 no 2963 0.125632267233703 4257 2251934 SGTC_2512 diallyl trisulfide 49.23 µM -1.14907550966321 0.14288600819974 no 2964 0.125262422942118 4272 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2698 st077697 67.5 µM -1.14977313969152 0.14273782984265 no 2965 0.125118660496943 4209 3154499 SGTC_2084 5306078 60.6385 µM -1.15131701289881 0.142410276771137 no 2966 0.124800920280262 4161 679340 SGTC_3092 9117248 49.47 µM -1.15288844760727 0.142077398713975 no 2967 0.124478087184576 4371 17141857 SGTC_1292 0kpi-0043 232 µM -1.15612518956747 0.141393418254299 no 2968 0.123814977011433 4266 3333905 SGTC_2383 9036125 200 µM -1.15699517473804 0.141209956262487 no 2969 0.123637165882037 4162 79580 SGTC_1994 st072947 40.9 µM -1.160599268366 0.140451646690658 no 2970 0.1229024515577 4301 5286565 YDL195W SEC31 SGTC_1679 SEC14.276 6.7 µM -1.16259948295476 0.140031992095593 no 2971 0.122496020335974 4259 1005053 YMR079W SEC14 SGTC_1303 1160-0052 261 µM -1.16287707120473 0.139973820145555 no 2972 0.12243969073225 4199 3562476 SGTC_237 nikkomycin 200 µM -1.16313313259113 0.139920173971102 no 2973 0.122387745588151 4257 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2162 5663267 200 µM -1.16482158173166 0.13956678507548 no 2974 0.122045610524098 4244 6456493 SGTC_1028 k015-0029 4.8 µM -1.16544791230397 0.139435849863803 no 2975 0.121918866399673 4219 4588309 SGTC_2643 anethole 100 µM -1.16632355704868 0.139252935313206 no 2976 0.121741826138453 4233 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2911 7942208 15.64 µM -1.16659798139489 0.139195644079544 no 2977 0.121686379464895 4292 1243384 SGTC_2029 5175081 200 µM -1.1677347795457 0.138958486996325 no 2978 0.121456881593024 4215 1380876 SGTC_2990 9074105 71.4286 µM -1.16900085639396 0.138694683970949 no 2979 0.121201643166412 4174 6502001 SGTC_1602 st001878 87.6 µM -1.16989395104561 0.138508801798185 no 2980 0.12102182423066 4243 595405 YLR310C CDC25 SGTC_1420 4'-methoxyflavone 42 µM -1.17075194175103 0.138330385850405 no 2981 0.120849250107219 4248 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1703 st026983 48.3 µM -1.17465314011153 0.137521122289239 no 2982 0.120066756981905 4289 1104023 SGTC_1906 st060206 94.7 µM -1.17856764142001 0.136712353750432 no 2983 0.119285191507318 4292 5133468 SGTC_1645 Cervolide 78 µM -1.17924167244906 0.136573422183104 no 2984 0.119150978314596 4272 23173 A fragrance. SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.18110053857562 0.136190772332376 no 2985 0.118781393011123 4325 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2428 5615643 7.78 µM -1.18157671020403 0.136092869983305 no 2986 0.118686849576841 4283 2253075 SGTC_152 4469-0003 551.229 µM -1.18405849942467 0.135583386408352 no 2987 0.118194953304818 4258 697280 SGTC_370 0180-0345 38.7 µM -1.18441551080968 0.13551020361434 no 2988 0.118124311613496 4119 3989527 SGTC_2304 7443016 91.4 µM -1.1846987003538 0.135452172612645 no 2989 0.118068298258709 4202 939854 SGTC_1574 spiramycin 23.7 µM -1.18471558780399 0.135448712586406 no 2990 0.11806495860637 4236 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2601 securinine 100 µM -1.18929999000327 0.13451166563163 no 2991 0.117160819638733 4258 442872 A GABA receptor antagonist. SGTC_198 3454-2873 16.191 µM -1.18950236016368 0.134470404194843 no 2992 0.117121021410777 4270 710957 SGTC_2436 5633522 8.09 µM -1.18965969761794 0.134438330522348 no 2993 0.117090085958658 4266 5724242 SGTC_3078 9116413 49.47 µM -1.18972705038764 0.134424602080731 no 2994 0.117076844928807 4205 17177322 SGTC_2108 5365811 200 µM -1.19965733633911 0.132411048978926 no 2995 0.115136224407383 4294 780283 SGTC_2286 7945697 125 µM -1.20282540923781 0.131773058242481 no 2996 0.114521944931018 4295 1245733 SGTC_1693 xanthone 101.9 µM -1.20326420004946 0.131684861468014 no 2997 0.114437049026109 4328 7020 An insecticide. SGTC_2016 5121758 140 µM -1.20354920215889 0.131627597986358 no 2998 0.114381931694997 4221 2795203 SGTC_1150 3909-7983 10.9 µM -1.20362521477809 0.131612328205499 no 2999 0.114367234601526 4277 23965914 SGTC_711 k292-0785 179 µM -1.20433181710829 0.131470441031617 no 3000 0.11423067688248 4205 4146315 SGTC_3300 9124615 50.48 µM -1.20475274115487 0.131385968839381 no 3001 0.114149384458639 4322 24824903 SGTC_1819 st053448 58.6 µM -1.20609868797771 0.131116112063161 no 3002 0.113889720344744 4196 2857616 SGTC_1131 3454-3128 32.3 µM -1.20615886488534 0.131104055790206 no 3003 0.113878120672548 4313 710982 SGTC_2106 5357045 167.29 µM -1.20635582779427 0.131064600184843 no 3004 0.113840160082931 4301 668842 SGTC_101 0490-5701 117.494 µM -1.20750711436802 0.130834138600518 no 3005 0.113618453444414 4131 4661669 SGTC_1205 4161-2785 76 µM -1.20951359102927 0.13043315700095 no 3006 0.113232796408769 4332 3498106 SGTC_1407 3909-7909 12.3 µM -1.21025044743893 0.130286114546949 no 3007 0.113091402840068 4308 4411780 SGTC_651 3253-0966 34.4 µM -1.21504278828059 0.129332583548068 no 3008 0.112174886155627 4312 781462 SGTC_1979 st071809 45.3 µM -1.21551500837649 0.129238888461969 no 3009 0.112084864050504 4353 4976333 SGTC_2470 5664817 21.68 µM -1.22110651976382 0.128133030523913 no 3010 0.111022845741517 4337 2859561 SGTC_2695 st077686 51.995 µM -1.22175977893143 0.128004262637568 no 3011 0.11089924136606 4301 2876092 SGTC_2402 5553605 200 µM -1.22183641135568 0.127989163048211 no 3012 0.110884748066338 4381 6758546 SGTC_2249 haloperidol 116.36 µM -1.22214034480431 0.127929288440228 no 3013 0.110827279252704 4269 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3306 9127676 59.7925 µM -1.22454289837165 0.127456672569355 no 3014 0.110373746875182 4272 41905287 SGTC_298 1391-0729 10 µM -1.22777249523912 0.126823280846329 no 3015 0.109766191735213 4252 3237558 SGTC_851 0394-0702 453 µM -1.23307605129034 0.125787902761182 no 3016 0.108773695766679 4318 762646 SGTC_1464 k208-0027 110 µM -1.23353520757136 0.125698542849157 no 3017 0.108688074754945 4308 X1464 SGTC_1594 piperine 70.1 µM -1.23765633014169 0.124898482091567 no 3018 0.10792175902779 4299 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1128 3448-9350 235 µM -1.24277366845863 0.123909980230868 no 3019 0.106975624132235 4338 619386 SGTC_420 mitomycin C 81.9 mM -1.24536446824396 0.123411616033311 no 3020 0.106498903996574 4308 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1349 flufenamic acid 69 µM -1.24618290291226 0.123254474837751 no 3021 0.106348627182707 4257 3371 A non-steroidal anti-inflammatory. SGTC_1834 st055981 52.8 µM -1.24805342472669 0.122895857234229 no 3022 0.106005746539862 4327 471719 YDL150W RPC53 SGTC_3173 9105693 49.47 µM -1.24812954230858 0.122881279432314 no 3023 0.105991810551764 4316 17096658 SGTC_147 4466-0538 29.23 µM -1.24924934920127 0.122666957631846 no 3024 0.105786943679984 4413 6742687 YHR072W ERG7 SGTC_3172 9105863 49.47 µM -1.25118059304998 0.122297949835888 no 3025 0.105434298508034 4405 2348785 SGTC_524 r073-0010 27.8 µM -1.25279368070901 0.121990330744869 no 3026 0.105140401011633 4249 2772106 SGTC_1511 0906-3109 28.5 µM -1.25427017983622 0.121709236089542 no 3027 0.104871909451878 4329 2882180 SGTC_629 3448-6466 76.7 µM -1.25690438453576 0.121208869419022 no 3028 0.10439413034055 4334 573744 SGTC_2271 7849410 118.62 µM -1.25823330091998 0.120956991802068 no 3029 0.104153697463543 4267 972430 SGTC_202 3594-0513 34.79 µM -1.26167221432568 0.120306903957475 no 3030 0.103533379549882 4399 708429 SGTC_1154 4088-0362 150 µM -1.26429345767111 0.119813043257018 no 3031 0.103062358465258 4338 6618304 SGTC_1387 3342-1166 1.8 µM -1.26729042229838 0.119250147517823 no 3032 0.102525731955997 4305 3418228 SGTC_124 0136-0217 7.121 µM -1.27349453093486 0.118090817359228 no 3033 0.101421306020146 4401 3976905 SGTC_112 phenothiazine 287.218 µM -1.27475575869973 0.117856116428592 no 3034 0.101197852147171 4296 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1224 0823-0416 294 µM -1.27586563666375 0.117649853247742 no 3035 0.101001510123521 4390 3598164 SGTC_3323 9138564 53.9225 µM -1.27840328850882 0.117179208449882 no 3036 0.100553632568513 4352 43912313 YNL103W MET4 SGTC_808 0711-0032 135 µM -1.27872877135181 0.117118939520818 no 3037 0.100496292154904 4329 4252555 SGTC_874 0599-0792 117 µM -1.27999938962283 0.116883872205475 no 3038 0.10027267528774 4358 765305 SGTC_162 k030-0015 37.8 µM -1.28408623557755 0.116130064469117 no 3039 0.0995558918042626 4417 1809920 YMR134W ERG29 SGTC_1389 3405-0187 19 µM -1.28542272359152 0.115884303166516 no 3040 0.0993223023638714 4327 799890 SGTC_3227 9130768 49.47 µM -1.29513896946897 0.114108720310383 no 3041 0.0976361468938021 4419 17720899 SGTC_3152 9099253 49.47 µM -1.29572466781752 0.114002310318507 no 3042 0.0975351798089087 4240 25236131 SGTC_521 r062-0005 13.8 µM -1.29973281271851 0.113276005432333 no 3043 0.0968462800462244 4288 2832033 SGTC_2552 juarezic acid 87.02 µM -1.30011361505871 0.113207173382005 no 3044 0.0967810159707946 4314 1549512 SGTC_2505 galangin 7.89 µM -1.30277703220927 0.112726580709779 no 3045 0.0963254470892753 4262 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1697 st025554 27.742 µM -1.30279419975241 0.112723487694382 no 3046 0.0963225157574694 4385 1269519 SGTC_1515 3460-0031 42.1 µM -1.30420440532084 0.112469622863369 no 3047 0.0960819491332836 4321 2876596 SGTC_3143 9086658 49.47 µM -1.30848213292433 0.111702046794001 no 3048 0.0953549154190497 4388 25236626 SGTC_1396 3511-0007 98.6 µM -1.31048858079307 0.111343312824344 no 3049 0.0950153023813803 4399 X1396 SGTC_709 3807-1509 243 µM -1.31108383234041 0.111237046248961 no 3050 0.0949147211852925 4440 1886677 YPL242C IQG1 SGTC_339 3091-4833 71.4 µM -1.31217919582956 0.111041687572343 no 3051 0.0947298398054909 4214 3240077 SGTC_1864 st057645 30.4 µM -1.31563256061374 0.110427386938332 no 3052 0.0941486997228975 4413 688666 SGTC_1012 4112-3522 18 µM -1.31687972810247 0.110206134950852 no 3053 0.0939394712879051 4383 3112398 SGTC_1682 st012968 530 nM -1.31740038887166 0.110113862001633 no 3054 0.093852225330796 4377 24207270 SGTC_3112 9123419 49.47 µM -1.32118216759704 0.1094453076015 no 3055 0.0932203153744411 4434 17015854 SGTC_2154 5570129 200 µM -1.32211145789206 0.109281471961736 no 3056 0.0930655194680914 4427 673366 SGTC_1286 0929-0070 131 µM -1.32224113398167 0.109258623837923 no 3057 0.093043933874877 4450 1420408 SGTC_1581 himbacine 57.9 µM -1.32337319266511 0.109059307859792 no 3058 0.0928556510520578 4389 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1612 st002233 45.4 µM -1.32516200079565 0.108744894186013 no 3059 0.0925587128445578 4395 1035021 SGTC_3163 9099914 49.47 µM -1.32777509566526 0.108286770396263 no 3060 0.0921262082931484 4452 16268368 SGTC_981 1488-1094 54.9 µM -1.32920740255255 0.108036250666913 no 3061 0.09188977676037 4359 3449522 SGTC_868 0527-0199 213 µM -1.33001222205656 0.107895665787693 no 3062 0.0917571222085264 4351 2849450 SGTC_3326 9140064 16.379 µM -1.33021135364951 0.107860902067347 no 3063 0.0917243222037427 4336 1868434 SGTC_9 0092-0002 10.449 µM -1.33078892958086 0.107760116448072 no 3064 0.0916292357915018 4387 759368 SGTC_986 1493-0483 84 µM -1.33106513485851 0.107711943272549 no 3065 0.0915837898993177 4335 40079 SGTC_2718 lomofungin 53.02 µM -1.33315076084323 0.10734868844912 no 3066 0.0912411670983335 4364 5351222 A RNA synthesis inhibitor. SGTC_511 blebbistatin 171 µM -1.33383713024755 0.10722933640458 no 3067 0.0911286197053695 4449 3476986 A myosin inhibitor. SGTC_2229 7354935 190 µM -1.33679823966822 0.106715529016321 no 3068 0.0906442519834021 4333 318112 SGTC_1734 st037168 69.4 µM -1.338814072321 0.106366762676118 no 3069 0.0903156042160769 4399 708907 SGTC_2260 7964312 200 µM -1.34105588030801 0.105979867073416 no 3070 0.0899511551813208 4447 231951 SGTC_369 0957-0393 4.5 µM -1.34399366808861 0.105474398823938 no 3071 0.0894752172296105 4397 6997992 SGTC_3158 9100007 49.47 µM -1.34581299889521 0.105162244982164 no 3072 0.0891814160984332 4403 19297233 SGTC_2484 5809818 12.04 µM -1.35511567166311 0.103576573854129 no 3073 0.0876903531856482 4369 2870548 SGTC_364 0083-0097 67.7 µM -1.35530072900356 0.103545207199734 no 3074 0.0876608814243642 4429 5207356 SGTC_1354 1498-1681 81 µM -1.35645875835238 0.103349081288999 no 3075 0.0874766244144145 4388 5754243 SGTC_1376 2910-0861 41.3 µM -1.35854000659143 0.102997275533285 no 3076 0.0871461985106406 4347 1112859 SGTC_1425 4048-4433 7.33 µM -1.36156089070702 0.102488186484251 no 3077 0.0866682523939765 4475 23734946 SGTC_1231 0242-0792 125 µM -1.36203157455389 0.102409030358053 no 3078 0.0865939603686177 4407 3707635 SGTC_2254 7938975 95.19 µM -1.36414119257899 0.102054796541485 no 3079 0.0862615661863285 4462 2969277 SGTC_2214 7179297 48.276 µM -1.37086248294154 0.100932146246324 no 3080 0.0852089142636719 4490 769744 SGTC_2565 isoliquiritigenin 100 µM -1.37086626089067 0.100931517761328 no 3081 0.0852083253005981 4439 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_815 1582-0027 36.9 µM -1.37179748842938 0.100776689364799 no 3082 0.08506324467982 4434 3128206 SGTC_983 1491-0821 12.2 µM -1.38179183134167 0.0991258965791395 no 3083 0.0835178139663204 4410 46495113 SGTC_11 0438-0307 1.3 µM -1.38425845172014 0.0987215380965538 no 3084 0.0831396655886946 4407 4011476 SGTC_1672 st016598 6.51 µM -1.38606532276543 0.0984261007341344 no 3085 0.0828634789708345 4391 4665860 YNL267W PIK1 SGTC_1914 st062367 72.6 µM -1.38607917262578 0.0984238386780334 no 3086 0.0828613646397757 4405 978205 SGTC_610 4215-0184 155 µM -1.38896565213767 0.097953228977722 no 3087 0.0824215974634609 4440 5605015 SGTC_10 0279-0212 42.575 µM -1.38963045238054 0.0978450744117036 no 3088 0.0823205618004344 4429 39851 YBR002C RER2 SGTC_1782 st039423 80.636 µM -1.39030443731366 0.0977355149940953 no 3089 0.0822182254960248 4445 2068169 SGTC_1899 st063254 59.6 µM -1.39697761005268 0.0966556096593158 no 3090 0.0812101520970131 4392 3093813 SGTC_3211 9128781 49.47 µM -1.39946944170838 0.0962546174161256 no 3091 0.0808361278886941 4373 17194361 SGTC_1649 st011737 51.3 µM -1.40118317157826 0.0959795499310949 no 3092 0.0805796526341579 4461 1761035 SGTC_2822 7994718 71.43 µM -1.40251434540449 0.0957662850065922 no 3093 0.0803808548843473 4440 1018011 SGTC_2379 9035213 200 µM -1.40460590251299 0.095431904957225 no 3094 0.0800692502369936 4439 646551 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.40768238144084 0.0949416270320768 no 3095 0.0796125705712219 4509 4620898 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.40903259544161 0.094727039313276 no 3096 0.07941276504755 4355 5355888 SGTC_3113 9123498 49.47 µM -1.41063634223669 0.0944726226471234 no 3097 0.0791759349785779 4554 8897275 SGTC_1269 0831-0796 3.05 µM -1.41205540257452 0.0942479248770132 no 3098 0.0789668244071686 4464 927758 SGTC_37 0566-0070 1.56 µM -1.41339820080164 0.0940356658720846 no 3099 0.0787693371664446 4365 1626686 SGTC_3060 1327-0027 12.5 µM -1.414039876824 0.0939343594039261 no 3100 0.0786750972096132 4357 16000455 YPR107C YTH1 SGTC_1472 k841-0093 193 µM -1.41530067133145 0.09373554245229 no 3101 0.0784901791319372 4545 X1472 SGTC_795 0685-0265 78 µM -1.41602240593736 0.0936218707362224 no 3102 0.0783844722306438 4444 302754 SGTC_431 k089-0097 107 µM -1.41615456533876 0.0936010669328122 no 3103 0.0783651275602751 4175 5499420 SGTC_2399 5884133 200 µM -1.41748105818234 0.0933924468049147 no 3104 0.0781711642607646 4402 722445 SGTC_2731 amoxapine 43.43 µM -1.41908333722711 0.0931409115050314 no 3105 0.0779373606070247 4602 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_269 exalamide 29 µM -1.41968830829395 0.0930460698654017 no 3106 0.0778492217000061 4400 3316 A derivative of salicylamide. SGTC_3102 9121669 49.47 µM -1.42696895702694 0.0919102722643381 no 3107 0.0767944213532809 4494 41905072 SGTC_393 acivicin 6.25 µM -1.43030549075139 0.0913932099105628 no 3108 0.0763146797986947 4309 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_3289 9119912 71.43 µM -1.43087253986343 0.0913055491479618 no 3109 0.0762333741956117 4450 17014829 SGTC_2982 9019404 25.97 µM -1.43272037439414 0.0910203228704863 no 3110 0.0759688822558361 4400 22333232 SGTC_1429 4049-0205 9.46 µM -1.43637033984752 0.0904588679798374 no 3111 0.0754484941737511 4508 22774478 SGTC_2053 5265679 138 µM -1.44178215576928 0.0896311358033016 no 3112 0.0746819191852252 4375 764595 SGTC_600 1495-0418 41.6 µM -1.4444777301862 0.0892209573801624 no 3113 0.0743023198252243 4446 5377768 SGTC_338 4055-0136 114 µM -1.45148913388585 0.0881605942232373 no 3114 0.0733218529065638 4440 2900563 SGTC_1431 4049-0260 9.09 µM -1.45200704654192 0.0880826423722243 no 3115 0.073249822969089 4494 3854841 SGTC_3001 9076041 71.4286 µM -1.45360473512247 0.0878424955206398 no 3116 0.0730279616865189 4476 16004211 SGTC_2366 9070441 60.58 µM -1.45402792020719 0.087778968905809 no 3117 0.0729692827896679 4438 6837235 SGTC_1623 st003709 20.3 µM -1.45552259716732 0.0875548690871158 no 3118 0.0727623195013608 4445 16192618 SGTC_2987 9018338 71.43 µM -1.45565810802057 0.0875345728094624 no 3119 0.0727435779779533 4483 5055682 SGTC_138 0850-0259 40.9225 µM -1.45627348042227 0.0874424489474691 no 3120 0.0726585167859619 4407 6813004 SGTC_1796 st049173 110.4 µM -1.45965367973804 0.0869377088529694 no 3121 0.0721926391302933 4456 94134 SGTC_695 3505-6186 243 µM -1.4615576021444 0.0866543701343789 no 3122 0.0719312399460767 4469 1819379 SGTC_1766 st045414 44.774 µM -1.46212746788018 0.0865696979676543 no 3123 0.0718531414761523 4485 253960 SGTC_1791 st048313 56.1 µM -1.46324631781067 0.0864036362074495 no 3124 0.0716999954873066 4487 1204976 SGTC_1056 3448-1962 115 µM -1.46471640690769 0.0861858051200715 no 3125 0.0714991533640034 4436 715507 SGTC_2343 7990716 14.84 µM -1.46966490908886 0.0854555771526503 no 3126 0.0708262655303824 4476 6456862 SGTC_1129 3453-1384 223 µM -1.46975434906516 0.0854424216678221 no 3127 0.070814148571707 4478 1084452 SGTC_1452 4194-0072 190 µM -1.47267431656832 0.0850137642058827 no 3128 0.0704194375762317 4529 1343545 SGTC_519 k048-0011 62.8 µM -1.47437189371016 0.0847652983341679 no 3129 0.0701907438337207 4502 6836379 SGTC_2092 5303694 80.6725 µM -1.47767215136406 0.0842838151202574 no 3130 0.069747775929024 4495 1963699 SGTC_2806 7952793 58.44 µM -1.47798481210766 0.0842383068807031 no 3131 0.06970592174882 4494 2972490 SGTC_2596 sinensetin 100 µM -1.48014890542595 0.0839238253205286 no 3132 0.0694167562818643 4489 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1180 1193-0155 285 µM -1.48132081509782 0.0837538942398752 no 3133 0.069260552169092 4532 2921347 SGTC_1859 st055998 20 µM -1.48324119728695 0.0834759909676521 no 3134 0.0690051696075809 4410 676301 SGTC_918 glabranin 770.725 nM -1.48328807279554 0.0834692161713619 no 3135 0.0689989449414198 4498 124049 Also referred to as licorice root. SGTC_1133 3473-0247 50 µM -1.4839241632956 0.083377324498053 no 3136 0.0689145203455664 4455 711311 SGTC_2784 7567673 72.73 µM -1.48656190687539 0.0829970789621836 no 3137 0.0685652775024358 4415 3471247 SGTC_251 melphalan 456.522 µM -1.48819257425183 0.0827626624124343 no 3138 0.0683500575119343 4525 460612 A DNA alkylator. SGTC_824 1304-0008 100 µM -1.49461622498913 0.0818440759749511 no 3139 0.0675073146232599 4515 768245 SGTC_1677 st019204 53.9 µM -1.49808155733377 0.081351732597946 no 3140 0.0670560310504283 4495 3945625 SGTC_1014 4130-3005 69.3 µM -1.49817623271394 0.0813383128431869 no 3141 0.0670437344804056 4500 743608 SGTC_2952 9073731 13.78 µM -1.49842343561385 0.0813032809589264 no 3142 0.0670116356456197 4493 16457353 SGTC_3348 9149464 3.537 µM -1.50098770934353 0.0809405609771375 no 3143 0.0666793702685471 4430 1951442 SGTC_476 mead acid 10 µM -1.50690400340631 0.0801083552664567 no 3144 0.0659176325716593 4568 5312531 An omega 9 fatty acid. SGTC_2328 6201408 200 µM -1.50745240647715 0.0800315438371862 no 3145 0.0658473672097411 4456 2890418 SGTC_1840 st055363 71 µM -1.51508327419706 0.0789685058744803 no 3146 0.0648756583992663 4520 676033 SGTC_848 0368-0089 85.6 µM -1.51613862294781 0.0788223335721787 no 3147 0.0647421519462346 4497 762535 SGTC_2581 avocatin a 64 µM -1.5247017612526 0.0776438567664803 no 3148 0.063666751133193 4445 6710728 A skin care supplement. SGTC_3013 9080133 71.4286 µM -1.52632653468604 0.0774217697572886 no 3149 0.0634642817736053 4559 17050193 SGTC_2771 fluoxetine 41.05 µM -1.52813370324809 0.0771753186348723 no 3150 0.0632396725071533 4498 3386 A selective serotonin reuptake inhibitor. SGTC_207 4185-0010 4.486 µM -1.53145506239636 0.0767239261720079 no 3151 0.0628284822516613 4578 3761753 SGTC_326 k292-0812 17.5 µM -1.53153695856547 0.0767128214115887 no 3152 0.0628183697376622 4503 3579357 SGTC_2875 9039966 71.43 µM -1.53339820656165 0.0764607737785548 no 3153 0.0625888851839767 4497 6463691 SGTC_1016 4226-1401 38 µM -1.53517373561348 0.0762209217164511 no 3154 0.0623705789895328 4514 2901613 SGTC_665 3914-0008 307 µM -1.5413123990921 0.0753960753176711 no 3155 0.0616203863189005 4480 1069549 SGTC_1260 0700-1617 7.75 µM -1.54309452119629 0.0751578920983393 no 3156 0.0614039219362667 4484 2853078 SGTC_2063 5246145 200 µM -1.54750654030403 0.0745706880896857 no 3157 0.0608705742992606 4557 711240 SGTC_2114 5491910 81.25 µM -1.55601416105398 0.0734482878451615 no 3158 0.0598523625103596 4532 2849228 SGTC_1123 mangostin 811.285 nM -1.56679529178449 0.0720445621781581 no 3159 0.0585812741341727 4523 5281650 An antioxidant. SGTC_499 genistein 192 µM -1.56758987487188 0.0719419252287693 no 3160 0.0584884382946304 4624 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2677 mitomycin C 100 µM -1.5685191876123 0.071822027429789 no 3161 0.0583800078030617 4599 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1560 lithocholic acid 53.1 µM -1.56949814110705 0.0716958909067708 no 3162 0.0582659561355693 4468 9903 A bile acid which acts as a detergent. SGTC_954 1189-0853 2.85 µM -1.57587329222599 0.0708786162586792 no 3163 0.0575275035805995 4474 2828194 SGTC_1919 st067113 52.3 µM -1.57869417393752 0.0705192800380582 no 3164 0.0572031109024671 4502 1268243 SGTC_1267 0828-0272 9.49 µM -1.58563097476063 0.069641596878526 no 3165 0.0564115227511385 4585 745334 SGTC_729 4092-0585 94.1 µM -1.58602379302628 0.0695921480385281 no 3166 0.0563669561686181 4558 2169061 SGTC_2715 st079500 56.4 µM -1.59030783996707 0.0690546163065096 no 3167 0.05588271615036 4536 28246688 SGTC_609 0986-0026 86.3 µM -1.59102052889914 0.0689655044347567 no 3168 0.0558024779054699 4527 2848610 SGTC_1322 1348-1070 12 µM -1.59872456804225 0.0680078705502626 no 3169 0.05494090808702 4545 6758089 SGTC_225 nsc-122657 1.016 µM -1.60208181810383 0.0675937805496373 no 3170 0.054568759019321 4561 275685 SGTC_957 1187-1561 14.1 µM -1.60232358909547 0.0675640353904324 no 3171 0.0545420359908961 4489 1538454 SGTC_792 4534-1957 155 µM -1.60510397863687 0.067222689780385 no 3172 0.0542354619354953 4515 1717904 SGTC_541 4513-1321 94 µM -1.61514605991027 0.0660009297409245 no 3173 0.0531395341905426 4523 747515 SGTC_1092 toremifene 6.32 µM -1.62524392516453 0.0647898027401288 no 3174 0.0520552972006296 4569 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1966 st070145 16.1 µM -1.62655892959865 0.0646333607531234 no 3175 0.0519154040143876 4534 3748532 SGTC_2299 7976368 114.88 µM -1.62732870152642 0.0645419196154647 no 3176 0.051833652634317 4543 2979718 SGTC_3057 9095946 49.47 µM -1.63209910925901 0.0639774827592479 no 3177 0.0513293046933099 4611 24540043 SGTC_2333 9017922 200 µM -1.63382755059487 0.0637739227228399 no 3178 0.0511475328349509 4545 3163164 SGTC_325 2810-4341 181 µM -1.63560192586614 0.0635654774446581 no 3179 0.0509614635268336 4560 774970 SGTC_2267 7931562 200 µM -1.63970437230812 0.0630855713824505 no 3180 0.0505333247038372 4524 934880 SGTC_1573 oleylamine 1.06 µM -1.64302066121153 0.0626996968054435 no 3181 0.050189329256121 4549 5356789 An amine of the fatty acid oleic acid. SGTC_1608 st001473 40.5 µM -1.64458406998101 0.0625184218957292 no 3182 0.0500278070945538 4529 7292267 SGTC_773 4358-1457 44.6 µM -1.64503121926449 0.0624666508175841 no 3183 0.0499816865780949 4558 1186886 SGTC_3196 9111891 49.47 µM -1.64893583467502 0.0620159925102862 no 3184 0.0495803903987053 4545 18891510 SGTC_2086 5274770 176.623 µM -1.66121053771653 0.060615796097753 no 3185 0.0483355849632795 4602 689278 SGTC_483 fpl-64176 144 µM -1.66275612245692 0.0604412556280207 no 3186 0.0481806314840409 4680 3423 SGTC_3063 1327-0034 4 µM -1.66354332133862 0.0603525097736215 no 3187 0.0481018633173847 4454 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_914 3820-6779 408 µM -1.66969425715733 0.0596625835902515 no 3188 0.0474899352800243 4500 2893481 SGTC_348 k064-0012 10.7 µM -1.6778533061226 0.0587569693180219 no 3189 0.0466878699844526 4539 5066323 SGTC_1471 k673-0312 37 µM -1.6831231998153 0.0581777953612618 no 3190 0.0461756220972951 4572 24099884 SGTC_2159 5658611 73.75 µM -1.69216899742191 0.0571941084344365 no 3191 0.0453068779440338 4567 793844 SGTC_1662 st014054 52 µM -1.69244000431914 0.0571648409675863 no 3192 0.0452810551269996 4663 2838777 SGTC_2166 5933061 31.504 µM -1.70004546625592 0.0563482844299343 no 3193 0.0445611868643734 4576 2877375 SGTC_2273 7815444 169.05 µM -1.70587231836391 0.0557289299905688 no 3194 0.0440159273542651 4519 2824616 SGTC_1423 4048-0112 5.59 µM -1.7094010374433 0.0553564710277185 no 3195 0.0436883444499236 4636 X1423 SGTC_2444 5485484 36.41 µM -1.71025351469421 0.0552667868683424 no 3196 0.0436095018553032 4626 6790631 SGTC_2446 5162541 200 µM -1.71131285891308 0.055155499392844 no 3197 0.0435116869144362 4561 1549321 SGTC_2551 apiole 73.87 µM -1.71204531275208 0.0550786563574265 no 3198 0.0434441591266564 4534 10659 A possible DNA adduct former. SGTC_764 1951-2361 146 µM -1.71346041034805 0.0549304355352898 no 3199 0.0433139353634973 4592 5438930 SGTC_457 grayanotoxin iii 135 µM -1.71466621663753 0.054804385295209 no 3200 0.0432032204218382 4392 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_91 0417-1751 58.384 µM -1.71515510155855 0.0547533443792978 no 3201 0.0431583970664944 4666 6795624 SGTC_838 0109-0203 71.4 µM -1.72448692784847 0.0537862627349571 no 3202 0.0423099884085285 4638 759422 SGTC_1218 1348-1416 30.7 µM -1.72657406484504 0.0535718292792215 no 3203 0.0421220935343463 4576 6787668 SGTC_412 gemfibrozil 100 µM -1.72796677108306 0.0534291191137409 no 3204 0.0419970909832527 4554 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2796 7949634 45.45 µM -1.73195709838595 0.0530218992147742 no 3205 0.0416406006305335 4571 2971588 SGTC_1673 st016611 27.3 µM -1.73607179918732 0.0526045683219485 no 3206 0.0412755700145791 4592 5226799 SGTC_2465 5809242 33.21 µM -1.74374938833119 0.0518328473378277 no 3207 0.0406013996320238 4659 2731748 SGTC_1058 3448-5425 97.3 µM -1.74591422217571 0.0516168807419802 no 3208 0.0404129290854627 4560 7279705 SGTC_1848 st056003 16.4 µM -1.75083420516417 0.0511287174757371 no 3209 0.0399872363968907 4612 146492 SGTC_2972 9093619 59.92 µM -1.75144554960316 0.0510683170314711 no 3210 0.0399345963807225 4575 25236256 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.75355241631707 0.0508605949072209 no 3211 0.0397536152708735 4584 6728940 SGTC_581 0958-0271 211 µM -1.75570010414744 0.0506495410421628 no 3212 0.0395698145146211 4620 4591145 SGTC_2498 4'-Methoxychalcone 54.63 µM -1.75705649819869 0.0505166076138638 no 3213 0.0394540897928427 4603 641818 YHR062C RPP1 SGTC_333 3486-0131 40.1 µM -1.7608239360376 0.0501488375962358 no 3214 0.039134103617604 4624 6744690 SGTC_1902 st060212 70.5 µM -1.76923401466188 0.0493355622931132 no 3215 0.0384274149862147 4604 688944 SGTC_3036 9090181 49.47 µM -1.78993918755639 0.0473781616691723 no 3216 0.0367318440756279 4676 25236586 SGTC_2393 9031399 185.94 µM -1.79618360648835 0.0468002056081919 no 3217 0.0362326605316294 4603 1526623 YDL150W RPC53 SGTC_337 1315-0038 354 µM -1.79627917721322 0.0467914041407059 no 3218 0.0362250639040513 4611 1626437 SGTC_3229 9132204 49.47 µM -1.7965375731246 0.0467676141375276 no 3219 0.0362045313239718 4707 17682924 SGTC_2198 6589944 200 µM -1.80206093111777 0.0462614060072511 no 3220 0.0357679098191903 4641 5290268 SGTC_245 methotrexate 289.6 µM -1.8022158997873 0.0462472670472678 no 3221 0.0357557220490772 4582 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1567 st069303 68.4 µM -1.80387246627039 0.046096342706587 no 3222 0.0356256511191081 4619 5581319 SGTC_1357 1503-1303 39.5 µM -1.81311977452117 0.0452611046589791 no 3223 0.0349066749327558 4605 292895 SGTC_1394 3474-0001 65.7 µM -1.8146839831857 0.0451210331684872 no 3224 0.0347862439277174 4628 5017666 YIL048W NEO1 SGTC_1063 disulfiram 1.84 µM -1.81497603568776 0.0450949191861983 no 3225 0.0347637961621253 4657 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_735 3076-0345 636 µM -1.81718973748281 0.0448973754905439 no 3226 0.0345940329113047 4627 2888990 SGTC_2188 6126565 140.678 µM -1.82386158594508 0.0443062119320101 no 3227 0.0340865002084198 4556 874518 SGTC_1372 2752-0194 270 µM -1.82509582246597 0.0441975422653705 no 3228 0.0339932852506652 4570 823334 SGTC_962 1254-0300 21.5 µM -1.84154560818147 0.0427696181888703 no 3229 0.0327708217142344 4629 7340576 SGTC_2811 7967822 32.47 µM -1.84292012338166 0.0426520111613885 no 3230 0.0326703368556192 4635 2232244 SGTC_2300 7976697 71.57 µM -1.85256253531079 0.0418343144935533 no 3231 0.0319725432497176 4551 2236109 SGTC_1787 fluconazole 80 µM -1.85457210229734 0.0416655077555462 no 3232 0.0318286775070286 4280 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_821 1114-0266 29.2 µM -1.85473347525781 0.0416519761437672 no 3233 0.0318171479813362 4663 3123235 SGTC_1710 st031758 61.5 µM -1.86416094847587 0.0408676122988895 no 3234 0.0311495527899064 4677 5394341 SGTC_2522 biochanin a 4.94 µM -1.87404650022459 0.0400580506604943 no 3235 0.0304620081180564 4635 5280373 A possible chelator. SGTC_2691 st077356 60.2 µM -1.87836169139165 0.0397087740934111 no 3236 0.0301658512057596 4614 2839272 SGTC_318 1488-0629 67.2 µM -1.8834510402052 0.0393000230172238 no 3237 0.0298196344661131 4701 3662576 SGTC_3355 9151058 44.0485 µM -1.88885066029988 0.0388701025984759 no 3238 0.0294559211602378 4664 17015728 SGTC_1352 1496-0991 99 µM -1.90798709137366 0.0373771959658454 no 3239 0.0281964423548814 4665 3000039 SGTC_2007 4011539 71.82 µM -1.91162632657861 0.03709865498981 no 3240 0.0279620700435748 4641 45595301 SGTC_554 4483-2211 187 µM -1.91464258687798 0.0368690832314004 no 3241 0.0277690500490781 4685 747107 SGTC_2009 4012297 12.05 µM -1.91497366696736 0.0368439551669503 no 3242 0.0277479309731281 4608 45595307 SGTC_3098 9119039 49.47 µM -1.92081586571888 0.0364028475789527 no 3243 0.0273774627728472 4660 17161528 SGTC_3345 9148410 3.559 µM -1.92089958217086 0.036396558227047 no 3244 0.0273721842315666 4605 4903596 SGTC_2266 7929956 200 µM -1.92976650018438 0.0357354330735446 no 3245 0.0268178880166991 4641 2967153 SGTC_531 3788-1495 174 µM -1.93591554187549 0.0352827592288715 no 3246 0.0264390229577124 4657 2896655 SGTC_1278 0874-0585 172 µM -1.93895382393439 0.0350608323556247 no 3247 0.0262534805492189 4695 766306 SGTC_508 roscovitine 141 µM -1.94030338916906 0.034962623410639 no 3248 0.0261714148708897 4721 160355 A CDKinase inhibitor. SGTC_2782 7736369 71.43 µM -1.95575995528997 0.0338538565532947 no 3249 0.0252467191132571 4638 2950836 YOL077C BRX1 SGTC_1491 4138-0063 26.5 µM -1.95654824454148 0.0337980933421045 no 3250 0.0252003025110409 4703 23883227 SGTC_219 mitoxanthrone 164.414 µM -1.96283326931663 0.0333561916099268 no 3251 0.0248327753316897 4655 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_880 0833-0487 87.2 µM -1.9653914525877 0.0331776926845898 no 3252 0.0246844740059586 4666 76075 SGTC_2061 5245884 80.95 µM -1.98368421935129 0.0319241087228593 no 3253 0.0236455269304712 4663 573863 SGTC_1104 tacrolimus 29.8 µM -2.00806130564144 0.0303146238531741 no 3254 0.022318388726421 4729 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2712 st079126 47.7 µM -2.01076077489808 0.0301406025763769 no 3255 0.0221753655792029 4686 3152970 SGTC_2145 5634607 200 µM -2.01764429752917 0.029700601662887 no 3256 0.0218141599580094 4689 308662 SGTC_2033 5192550 145 µM -2.03886265773788 0.0283777204501468 no 3257 0.0207318683562734 4688 182073 SGTC_3192 9110362 49.47 µM -2.04355907377621 0.0280916425325146 no 3258 0.0204985629318943 4672 16649480 SGTC_3141 9094609 49.47 µM -2.0521589584918 0.02757401298279 no 3259 0.0200771083110768 4647 25236309 YDL196W YDL196W SGTC_1808 st050063 61.5 µM -2.06201183891698 0.0269907629179059 no 3260 0.0196033044267183 4671 4011993 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -2.06695279997726 0.0267021770217901 no 3261 0.0193693008736619 4685 1377 SGTC_796 1234-0020 70.7 µM -2.07363135475054 0.0263162036559916 no 3262 0.0190567804499555 4671 46495034 SGTC_2482 5981709 142.65 µM -2.0937733909832 0.0251802760680441 no 3263 0.0181400857975754 4674 877755 SGTC_1849 st056239 19.2 µM -2.09889764910031 0.02489793697869 no 3264 0.0179129620731809 4699 5393181 SGTC_784 4579-0127 173 µM -2.10040248469984 0.0248155287797479 no 3265 0.0178467253180904 4712 1948547 SGTC_845 0330-0138 4.51 µM -2.11473713412776 0.0240419389066349 no 3266 0.017226178777922 4689 9039800 SGTC_649 1123-0311 367 µM -2.11726162391661 0.023907821649706 no 3267 0.0171188249736559 4619 693629 YIL048W NEO1 SGTC_881 0833-0569 170 µM -2.12605025756359 0.0234458077686085 no 3268 0.0167495375360121 4717 5418700 SGTC_1904 st060225 78 µM -2.12732472869324 0.0233794372555248 no 3269 0.016696555737527 4696 66595 SGTC_1870 st057514 26.5 µM -2.13125718004395 0.0231756431077496 no 3270 0.0165339803165137 4711 5393161 SGTC_3035 9091303 49.47 µM -2.13463747264078 0.0230016611548876 no 3271 0.0163953170348723 4740 25237002 SGTC_471 1-acyl-paf 4 µM -2.14346437067444 0.0225525248705305 no 3272 0.0160379145393932 4699 16759367 SGTC_970 1315-0089 19.5 µM -2.1527195554061 0.0220895601151746 no 3273 0.0156703628314392 4700 6811083 YLR033W RSC58 SGTC_118 0083-0097 135.343 µM -2.1705837649057 0.0212186178245922 no 3274 0.0149813252095539 4681 5207356 SGTC_2706 st078239 82.5 µM -2.18948701227857 0.0203288250020965 no 3275 0.0142807307563554 4707 15434492 SGTC_3286 9117135 37.221 µM -2.19797374163632 0.0199397535456975 no 3276 0.0139754886066657 4681 3438150 SGTC_3 0833-0587 95.581 µM -2.20140988049624 0.019784031435109 no 3277 0.0138535100799207 4637 5382644 SGTC_139 0099-0334 718.624 µM -2.20671072713949 0.0195458278101151 no 3278 0.0136671376649559 4708 97690 SGTC_2081 5214970 32.255 µM -2.2256999248107 0.0187124051322764 no 3279 0.0130171439042661 4702 2063512 SGTC_79 0052-0007 94.094 µM -2.23110790199327 0.0184806594630738 no 3280 0.0128369912271912 4711 2801472 SGTC_1325 1431-0015 227 µM -2.25696311048628 0.0174061883617102 no 3281 0.0120051899675209 4731 1103340 SGTC_777 1315-0167 517 µM -2.26350337894293 0.0171430041333879 no 3282 0.0118023382774239 4745 4221767 SGTC_572 0960-0087 17.7 µM -2.28412125118279 0.0163354741881898 no 3283 0.0111822029839789 4722 6796365 SGTC_2783 7738165 71.43 µM -2.29637723675596 0.0158710613554821 no 3284 0.0108271606790119 4712 17201110 SGTC_1909 st060837 51.5 µM -2.31718200512104 0.0151086213331183 no 3285 0.0102469096753955 4698 678937 SGTC_2526 patulin 37.61 µM -2.34079776022051 0.014281508559367 no 3286 0.00962129372200042 4725 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_206 4546-0025 72.014 µM -2.35017381443244 0.0139641067774159 no 3287 0.009382323139365 4748 6620745 YIL048W NEO1 SGTC_2181 6316240 54.2555 µM -2.3809591000353 0.0129643484898996 no 3288 0.00863381451890109 4758 12779990 SGTC_820 1582-0060 59.9 µM -2.38157572890812 0.0129449725459353 no 3289 0.00861937293766468 4755 3848840 SGTC_2553 4-methylesculetin 85.09 µM -2.38364038199785 0.012880278413089 no 3290 0.00857117244604834 4731 5319502 SGTC_261 5-fluorouridine 15.376 µM -2.40529314116962 0.0122184789347766 no 3291 0.00807974880672251 4764 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_78 0336-0123 156.75 µM -2.41790719945903 0.0118466879347447 no 3292 0.00780502866540666 4686 6765896 SGTC_1032 k061-1018 98.7 µM -2.42104730434777 0.0117556757125022 no 3293 0.007737931630278 4764 4005393 SGTC_1341 1486-1360 280 µM -2.42683640385621 0.0115894752974049 no 3294 0.00761556113956646 4771 3976547 SGTC_2164 5685496 200 µM -2.43907557480164 0.0112448027104027 no 3295 0.00736244420654064 4744 759046 SGTC_2351 9026858 72.31 µM -2.44855143123789 0.0109841026957843 no 3296 0.0071715975489997 4703 1409300 SGTC_2969 9091408 28.7 µM -2.46526162904408 0.0105371687330395 no 3297 0.00684566199593342 4708 4286311 SGTC_769 0302-0231 76 µM -2.46819457476137 0.0104603801325088 no 3298 0.00678982413860112 4703 571869 YER009W NTF2 SGTC_230 MPP+ 141.667 µM -2.49960726604311 0.00966805488511055 no 3299 0.00621655266497113 4761 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2507 purpurin 79.67 µM -2.50699187121543 0.00948959035587476 no 3300 0.00608817559428161 4740 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2297 7971671 152.32 µM -2.53113658785499 0.00892603330677277 no 3301 0.00568467826298771 4743 909016 SGTC_971 1315-0384 26.7 µM -2.53323593098427 0.00887844770187761 no 3302 0.0056507428665068 4774 6769120 SGTC_2404 5161160 200 µM -2.54514618791537 0.00861266490743098 no 3303 0.00546159987820473 4744 2831543 SGTC_1879 gemcitabine 100 µM -2.55900629250896 0.0083121787409116 no 3304 0.00524859206527519 4747 60750 A nucleoside analog which inhibits DNA replication. SGTC_3037 9091026 49.47 µM -2.5712414309084 0.00805461260944487 no 3305 0.00506673275913308 4675 25236398 YIL048W NEO1 SGTC_2776 terbinafine 19.92 µM -2.57308341350698 0.00801645022687684 no 3306 0.00503984556100324 4757 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2815 7968870 71.43 µM -2.57596394879444 0.00795708963757679 no 3307 0.00499805340193772 4716 2977326 YHR190W ERG9 SGTC_1473 k844-0725 134 µM -2.58317565088973 0.00781016668969704 no 3308 0.00489477339434812 4784 54682906 SGTC_1656 st012921 11 µM -2.58815167103998 0.00771018764421188 no 3309 0.00482462417117099 4727 6732821 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -2.59714147654309 0.00753241604312341 no 3310 0.00470015984996517 4727 676296 Flavone; oxidizing agent. SGTC_1393 3470-5649 58.2 µM -2.62273863860999 0.00704585948714338 no 3311 0.00436130788280897 4767 4108395 SGTC_601 0986-0029 62.9 µM -2.64378935939897 0.00666672791621248 no 3312 0.00409918288945251 4747 24747981 SGTC_2630 antimycin a 100 µM -2.64977882444482 0.00656220381603244 no 3313 0.00402722401209913 4730 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_407 eburnamonine 100 µM -2.65397449994486 0.00648984945172362 no 3314 0.00397749191175705 4713 3195 SGTC_1881 5652484 16 µM -2.65859745682352 0.00641094459780078 no 3315 0.00392333264682533 4765 2255129 SGTC_50 0929-0078 56.389 µM -2.67085296264689 0.0062058605366671 no 3316 0.00378293903448586 4716 1377751 SGTC_767 0929-0023 86 µM -2.71205890258873 0.00555828324704525 no 3317 0.00334333548052909 4788 1204563 SGTC_2528 xanthyletin 44.79 µM -2.76042384492345 0.00487531748781663 no 3318 0.0028863207438157 4774 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2022 5136654 200 µM -2.76515727424864 0.00481267173542648 no 3319 0.0028447678545615 4764 1713771 SGTC_1172 0370-0043 85 µM -2.78760716507697 0.00452522144130809 no 3320 0.00265494443903322 4774 376585 SGTC_958 1222-0007 33 µM -2.78937608978879 0.0045032371897847 no 3321 0.00264048501035305 4783 7312461 SGTC_1732 st034308 51.822 µM -2.8048792623311 0.00431460713041027 no 3322 0.00251677154266261 4744 830119 SGTC_1816 st051957 91.6 µM -2.83947761755226 0.0039188857924271 no 3323 0.00225937325382216 4794 674121 SGTC_1225 1216-0074 20.6 µM -2.8865659795381 0.0034325938353525 no 3324 0.00194735538589177 4789 4241466 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -2.89030118058826 0.00339644490455246 no 3325 0.00192436448815431 4740 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2082 5219693 150 µM -2.9340372265646 0.00299792046387026 no 3326 0.00167292038305477 4771 2834649 SGTC_1355 1499-0035 1.68 µM -2.93691939840315 0.00297320099442352 no 3327 0.00165745124352433 4793 1548538 SGTC_1883 5-benzylidenerhodanine 20 µM -2.94769909329755 0.00288236690944822 no 3328 0.00160074262323914 4791 1273210 SGTC_2756 carbadox 75.1 µM -2.99399476864233 0.00252005015062093 no 3329 0.00137675332804989 4751 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_264 promethazine 12.5 mM -3.01445142933967 0.00237349299262589 no 3330 0.00128722214359948 4748 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -3.06393462105721 0.00205035464492297 no 3331 0.00109223321744921 4797 688664 SGTC_255 tunicamycin 200.472 nM -3.06806760267066 0.00202526058899552 no 3332 0.0010772393631706 4768 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1003 4049-0218 100 µM -3.13740759645653 0.00164379217023373 no 3333 0.000852244957376083 4788 295161 SGTC_723 4182-0001 115 µM -3.16621631218697 0.00150552016294217 no 3334 0.00077217951503985 4788 744821 YLR208W SEC13 SGTC_299 1273-0059 1.44 µM -3.22057100663832 0.00127315051823106 no 3335 0.000639677477525624 4667 2848077 SGTC_1809 st050081 57.6 µM -3.2622401833111 0.00111776033268335 no 3336 0.000552677232182971 4799 5036894 SGTC_1337 1486-1011 40.3 µM -3.32934799268173 0.000903643573160141 yes 3337 0.000435247831873034 4804 X1337 SGTC_2810 7959871 45.46 µM -3.35248460180758 0.000839039643320378 yes 3338 0.000400448482163554 4783 2974535 SGTC_2441 5730946 39.09 µM -3.37313663329327 0.000784991063860197 yes 3339 0.000371585323501212 4799 1774275 SGTC_2178 5812956 200 µM -3.38744886659555 0.000749435367077934 yes 3340 0.000352729329604224 4800 5403383 SGTC_2310 7668677 200 µM -3.40231065314283 0.000714089566509676 yes 3341 0.000334093192108058 4779 2197143 SGTC_398 bronopol 33.3 µM -3.4487236752522 0.000613360658128575 yes 3342 0.00028162138246024 4789 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_58 0957-0393 9 µM -3.45970722164819 0.00059152740635986 yes 3343 0.000270381505674973 4542 6997992 SGTC_453 enantio-paf c16 10 µM -3.50087941073983 0.00051591934221256 yes 3344 0.000231862812465165 4496 13871343 A lipid and platelet activating factor SGTC_2830 7992007 71.43 µM -3.50719519891762 0.000505145907217021 yes 3345 0.000226428411305243 4771 1952075 SGTC_2078 5212016 200 µM -3.59341589040497 0.000377449612692175 yes 3346 0.000163185516647271 4799 1899708 SGTC_2085 5307070 144.047 µM -3.62050070453323 0.000343991722842255 yes 3347 0.000147016725120484 4795 2840351 SGTC_539 4859-0462 2.54 µM -3.76744441068356 0.000205690377503794 yes 3348 8.24636250733412e-05 4802 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -3.76809073767114 0.000205217473897745 yes 3349 8.22504558603722e-05 4801 6708784 An antioxidant flavonoid SGTC_2872 9044037 25.97 µM -3.79303200927925 0.000187725426213527 yes 3350 7.44094821420415e-05 4809 6465195 SGTC_2777 climbazole 1.536 µM -3.80570890130331 0.000179378684519788 yes 3351 7.06993051301997e-05 4736 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2250 alverine citrate 130 µM -3.8644005591652 0.000145063981609151 yes 3352 5.5681172931224e-05 4754 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_173 1273-0061 2.693 µM -3.98784256149681 9.19438788533671e-05 yes 3353 3.33384432588203e-05 4797 2847414 YPL266W DIM1 SGTC_2582 agaric acid 100 µM -4.24072491400681 3.47087805434139e-05 yes 3354 1.11399527976332e-05 4722 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_310 1273-0058 1.06 µM -6.0471749801674 6.77141331241485e-09 yes 3355 7.3703818537818e-10 4752 2734232 SGTC_1718 roemerine 11.9335 µM -6.50374497286452 5.01481534813689e-10 yes 3356 3.91723363083638e-11 4794 235224 An aporphine alkaloid with mutagenic activity.