SGTCid condition conc unit CLB3|YDL155W.score CLB3|YDL155W.strain.pval CLB3|YDL155W.strain.significant CLB3|YDL155W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_514 4466-0038 2.65 nM 5.02711446294357 1.50273265134062e-07 yes 1 2.48957589718779e-07 104 5722064 SGTC_669 0108-0021 26.2 µM 4.60477146781177 1.35490355487888e-06 yes 2 2.06459528446263e-06 53 17201 SGTC_996 3970-0799 1.8 µM 4.49746667791973 2.30210466319733e-06 yes 3 3.4383967280431e-06 63 6615648 YGL040C HEM2 SGTC_2480 5767542 37.17 µM 4.45406743970792 2.84321201264397e-06 yes 4 4.21293075237362e-06 6 2867358 SGTC_2275 7947463 200 µM 4.27329836348494 6.7123264320385e-06 yes 5 9.63012284580383e-06 31 1225414 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 4.27232253422711 6.74292559024356e-06 yes 6 9.67237479531051e-06 19 16623 A steroid. SGTC_2954 9074818 52.69 µM 4.18561033523518 1.00628673824669e-05 yes 7 1.42200438861477e-05 32 16648742 SGTC_225 nsc-122657 1.016 µM 4.04422448697329 1.90208130818978e-05 yes 8 2.62483005576874e-05 10 275685 SGTC_1413 3910-0535 34.4 µM 3.9613050822072 2.7375759343711e-05 yes 9 3.72706092038613e-05 13 2876951 SGTC_1683 st010134 710 nM 3.8680819390265 4.08888197462716e-05 yes 10 5.48474035464701e-05 31 3818134 SGTC_654 1124-0271 80.9 µM 3.78645281956122 5.76890430069002e-05 yes 11 7.64065472483867e-05 25 5403748 SGTC_2917 7979103 53.79 µM 3.77525025440634 6.04483781182001e-05 yes 12 7.99235526005432e-05 34 2980565 SGTC_757 1066-0008 322 µM 3.75228313452492 6.64991708051129e-05 yes 13 8.76156989120366e-05 22 6842497 SGTC_453 enantio-paf c16 10 µM 3.71270073406375 7.82867185394064e-05 yes 14 0.000102529653058703 163 13871343 A lipid and platelet activating factor SGTC_861 0443-0273 110 µM 3.60061896056082 0.000123229654424006 yes 15 0.000158730268675346 17 6149169 SGTC_3311 9131146 2.8755 µM 3.55229719548278 0.00014927799288995 yes 16 0.000190941635616265 137 4900406 YPR165W RHO1 SGTC_3338 9144300 39.5675 µM 3.54176532340405 0.000155601638055737 yes 17 0.000198729455722704 37 4901274 SGTC_2332 7982454 138.89 µM 3.52263865865533 0.000167731780837896 yes 18 0.000213636735055291 71 2981748 SGTC_3339 9145883 14.936 µM 3.37742457315957 0.000293106949912673 yes 19 0.000365840084384328 28 2030670 SGTC_2763 lisinopril 49.32 µM 3.25969419356612 0.000453890586200386 yes 20 0.000557661992482734 24 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2955 9076254 12.21 µM 3.23018687989164 0.000505391879541582 yes 21 0.00061854663919595 41 16459619 SGTC_425 3825-7017 13.1 µM 3.21534428718977 0.000533295099450204 yes 22 0.000651440789234207 56 3397440 SGTC_626 0214-0009 33 µM 3.21417493794185 0.000535552889087098 yes 23 0.000654099722435053 48 3437874 SGTC_1815 st051655 58.2 µM 3.18547482449959 0.000593816698917991 yes 24 0.000722583386553952 25 5984156 SGTC_826 1683-5028 118 µM 3.17165393864164 0.000623915469837518 yes 25 0.00075786755401125 41 722377 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 3.15967437602262 0.000651137481505164 yes 26 0.000789727767120739 63 5379071 SGTC_188 3229-0966 278.469 µM 3.128828076135 0.00072635568860762 yes 27 0.00087752481918562 74 5722370 SGTC_647 0140-0236 81 µM 3.09036125768635 0.000831362072858151 yes 28 0.000999565895121716 32 990837 SGTC_686 1319-0111 510 µM 3.07751048406241 0.000869442837657992 yes 29 0.00104368747894208 59 4562600 SGTC_3103 9120822 49.47 µM 3.04953536949041 0.000957949057179246 yes 30 0.00114597821750395 47 17141819 SGTC_2959 9079155 11 µM 3.04892518105342 0.000959968617091474 yes 31 0.00114830835384718 67 16189457 SGTC_159 3970-0959 50 µM 2.97621997471209 0.00123058191661006 no 32 0.00145912727878431 168 6615653 SGTC_2057 5236571 38.335 µM 2.95805859337579 0.00130828895515384 no 33 0.00154791635808873 91 54684039 YBR257W POP4 SGTC_2158 5657123 3.6195 µM 2.93204831648706 0.0014274065693887 no 34 0.00168367177079178 31 2858827 SGTC_912 3474-0017 2.18 µM 2.87684099795892 0.00171367677725987 no 35 0.00200838968737441 78 3360550 SGTC_3305 9127027 53.8275 µM 2.8572337374767 0.00182731498511821 no 36 0.00213675506232679 66 41905295 SGTC_450 aminopyrene 156 nM 2.84585735952927 0.0018963493796416 no 37 0.00221460151176776 100 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_621 3584-0052 32.1 µM 2.82753521427198 0.0020125277644531 no 38 0.00234539280216693 82 2273927 SGTC_3197 9113331 49.47 µM 2.81841424450345 0.00207273905017129 no 39 0.00241307504641368 121 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_501 nsc-95397 161 µM 2.81077045441762 0.00212445265536951 no 40 0.00247115160494665 51 262093 SGTC_435 c-PAF 6.7 µM 2.80995130990381 0.00213006338306551 no 41 0.00247744976814763 113 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_3058 9093861 49.47 µM 2.80906850105707 0.00213612522223731 no 42 0.00248425367804401 84 17217477 SGTC_2762 leflunomide 42.06 µM 2.78920977999941 0.00227668652308617 no 43 0.00264184141314085 99 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_673 1082-0474 110 µM 2.78159394851463 0.00233277785291574 no 44 0.00270463358896625 154 3098046 SGTC_843 0310-0051 143 µM 2.72363557970697 0.00280233337977749 no 45 0.00322838538557273 76 2065037 SGTC_990 3985-0011 41.3 µM 2.68078996269069 0.00320255120935671 no 46 0.00367243002974537 78 5399565 YGL099W LSG1 SGTC_3027 9089541 49.47 µM 2.67789591274691 0.0032313539860549 no 47 0.00370431186751996 101 9943819 SGTC_229 benomyl 22.8748 µM 2.65378756231012 0.00348049424996428 no 48 0.00397969595667019 88 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_998 3996-0085 177 µM 2.63686827905 0.00366550602452281 no 49 0.00418376581362192 90 715391 SGTC_3176 9106582 49.47 µM 2.63085850220209 0.00373331676276361 no 50 0.00425847440655784 19 17018027 SGTC_1697 st025554 27.742 µM 2.62690223944537 0.00377856880459955 no 51 0.00430830426791839 84 1269519 SGTC_3202 9113761 49.47 µM 2.60523379813275 0.00403524795865906 no 52 0.00459057933484466 156 4798415 SGTC_622 1348-1566 26.3 µM 2.59592898569981 0.00415018203944986 no 53 0.00471677801350203 104 7340407 SGTC_1916 st067606 49.2 µM 2.58188964826102 0.00432914461190748 no 54 0.00491304993604958 142 19590279 SGTC_2261 9010538 184.68 µM 2.559900047226 0.00462333524281932 no 55 0.00523511360657813 87 6457250 SGTC_1002 4049-0206 172 µM 2.5589605386832 0.00463629284325454 no 56 0.00524928289549883 149 4662749 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 2.55785796257747 0.00465154077756828 no 57 0.00526595500837447 84 803109 SGTC_3189 9110682 49.47 µM 2.55676892374149 0.00466664540863765 no 58 0.00528246864499839 111 17122418 SGTC_2675 theaflavin digallate 100 µM 2.55635356283633 0.00467241785386764 no 59 0.00528877909256983 114 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2880 9042983 58.44 µM 2.55306557440302 0.00471833767620156 no 60 0.00533896953930757 119 6464714 SGTC_3355 9151058 44.0485 µM 2.55046576441688 0.0047549309724242 no 61 0.00537895446967336 79 17015728 SGTC_1406 3909-7906 11.9 µM 2.55034680568776 0.00475661139987698 no 62 0.00538079040116845 99 X1406 SGTC_1121 fusaric acid 630.51 nM 2.54879426503252 0.00477859141480194 no 63 0.00540480243374886 126 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_627 1391-0720 175 µM 2.53514684777218 0.00497573482118223 no 64 0.00562000984510204 91 997839 SGTC_2055 5235184 200 µM 2.53082089753356 0.00503972023346213 no 65 0.00568979694265775 125 2836034 SGTC_2823 7987624 58.44 µM 2.51303978874256 0.00531048405270068 no 66 0.00598479170993595 149 2239440 SGTC_2692 st077426 47.7 µM 2.47888619849876 0.00586707953071254 no 67 0.0065896674087974 120 25238571 SGTC_2053 5265679 138 µM 2.46082113177134 0.00618192204024968 no 68 0.0069309727786734 147 764595 SGTC_689 0833-0039 98 µM 2.43835644379153 0.00659425779835984 no 69 0.00737710881846077 114 5374726 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 2.42109007432188 0.00692752079013296 no 70 0.00773702124648245 139 5357218 A potent inhibitor of glutathione S-transferases. SGTC_432 NS 1619 61.3 µM 2.38944432364952 0.00757709400408909 no 71 0.00843694061100603 147 4552 A K+/calcium channel activator. SGTC_3194 9111903 49.47 µM 2.35796908077708 0.00827578241905531 no 72 0.0091876116881729 138 17087251 SGTC_1123 mangostin 811.285 nM 2.3388460087344 0.00872737589616808 no 73 0.00967170230196213 181 5281650 An antioxidant. SGTC_2413 inermin 26.06 µM 2.32767446172713 0.00900107203184333 no 74 0.00996469810738391 198 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1363 1636-0063 10.4 µM 2.32448904603217 0.00908047769900733 no 75 0.0100496489905742 164 6072185 SGTC_2395 5646831 180.19 µM 2.32187469656996 0.00914610553092678 no 76 0.0101198418290206 160 6808628 SGTC_1023 4482-3888 16 µM 2.31713411119528 0.00926616780083027 no 77 0.0102482136792502 135 3303168 SGTC_1168 k815-0004 80.5 µM 2.31391980960706 0.00934835724114785 no 78 0.0103360606357679 123 642433 SGTC_1475 4092-1048 11.7 µM 2.31291847589027 0.00937409121813261 no 79 0.0103635609021362 190 2881759 SGTC_2100 5377183 190 µM 2.29873595283598 0.00974528772777013 no 80 0.0107599688248992 140 2844202 SGTC_1733 st037357 54.9 µM 2.29537100571163 0.00983522007532764 no 81 0.0108559357564948 187 1272339 YGL099W LSG1 SGTC_1215 3852-0577 11.2 µM 2.29536131193643 0.0098354801969179 no 82 0.0108562132917003 147 2884876 SGTC_2939 9044578 71.43 µM 2.29421062818228 0.00986640022391836 no 83 0.0108892015599759 180 2653634 SGTC_1125 tnp00248 1.32998 µM 2.29307253554136 0.00989706537691906 no 84 0.0109219146355256 221 24207736 SGTC_810 3825-7150 143 µM 2.26566588202837 0.0106610724506338 no 85 0.0117359239928489 117 22330411 YGL099W LSG1 SGTC_2666 tannic acid 100 µM 2.26452539768388 0.010693949274827 no 86 0.0117709097442773 177 16134267 A thiamine antagonist. SGTC_2338 7999974 200 µM 2.26298420792956 0.0107385175121183 no 87 0.0118183313971597 161 315925 SGTC_1176 0848-0131 83.3 µM 2.24268882732237 0.0113406809542297 no 88 0.0124584438072817 178 6769040 SGTC_3235 9132602 49.47 µM 2.23913425932187 0.0114491111383281 no 89 0.0125735908711413 173 4912240 SGTC_1345 1488-0192 31.4 µM 2.23477874632558 0.0115832006445764 no 90 0.0127159389205793 149 658348 SGTC_2857 9024691 58.44 µM 2.22484101605036 0.0118942602602464 no 91 0.0130459564225456 171 16478292 SGTC_2943 9068529 45.32 µM 2.20840178271555 0.0124247384783156 no 92 0.0136081388219803 177 3270634 SGTC_1713 st033146 12.748 µM 2.19910176036394 0.0127338226319029 no 93 0.0139353436996599 185 674619 SGTC_2768 sulfasalazine 50.2 µM 2.19831678735376 0.0127602129079901 no 94 0.0139632694625829 161 5384001 An antioxidant and salicylic acid derivative. SGTC_2385 9074692 200 µM 2.18687903663523 0.0131501437485297 no 95 0.0143756778331384 199 17046906 SGTC_2184 6075246 200 µM 2.1786518441062 0.013436950162967 no 96 0.014678770839084 162 2267320 SGTC_1945 st075991 56.6 µM 2.17590097792105 0.0135340448472617 no 97 0.0147813328375393 169 1084980 SGTC_1328 1441-0025 69.2 µM 2.16461660029764 0.0139387023506003 no 98 0.015208529332101 141 4562601 SGTC_2852 9023854 51.95 µM 2.15235120625709 0.0143903283321356 no 99 0.0156848518129872 174 19798528 SGTC_754 3474-0146 171 µM 2.15133175144289 0.0144284266963112 no 100 0.0157250119150368 198 24762078 SGTC_2918 7977171 22.06 µM 2.13786655550483 0.0149398439105716 no 101 0.016263787672581 171 2236483 SGTC_886 0866-0150 153 µM 2.13743984191334 0.0149563023493327 no 102 0.016281116889862 212 271463 SGTC_1856 st057054 55.7 µM 2.12700165113228 0.0153637873517886 no 103 0.0167099730021861 194 1266018 SGTC_307 1501-1223 22.3 µM 2.12588944173342 0.015407762489273 no 104 0.0167562331144108 165 2830329 SGTC_2565 isoliquiritigenin 100 µM 2.12528705042775 0.0154316252473165 no 105 0.0167813340737882 178 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_732 3970-1727 52.7 µM 2.11032294761012 0.0160346701292002 no 106 0.0174152741559091 149 1275699 SGTC_822 1487-0950 154 µM 2.1076772265085 0.0161433661340195 no 107 0.017529459245437 182 1958375 SGTC_1632 st005650 90 µM 2.10761587161008 0.0161458942920969 no 108 0.0175321147893337 192 2759605 SGTC_2101 5377231 179.231 µM 2.09754473082347 0.0165655047690955 no 109 0.0179726909062735 154 2844213 SGTC_1985 st071382 65.5 µM 2.08845401084313 0.0169522467332562 no 110 0.0183784498766193 179 6123237 SGTC_1779 st039427 55 µM 2.07499591121466 0.0175389484544068 no 111 0.0189934568606138 248 1124498 SGTC_640 3381-0960 37.1 µM 2.07186669306779 0.0176778228292045 no 112 0.0191389374380782 183 1745025 SGTC_431 k089-0097 107 µM 2.03848472060633 0.0192186286842081 no 113 0.020750740635603 286 5499420 SGTC_737 1950-0117 57.9 µM 2.03157954598796 0.0195512142013712 no 114 0.0210981195547636 212 5393513 SGTC_3034 9090421 49.47 µM 2.03011529241199 0.0196223642008769 no 115 0.0211724107181439 162 17173761 SGTC_1655 st012546 55.1 µM 2.02946130768453 0.0196542131341606 no 116 0.0212056630617684 196 720985 YLR208W SEC13 SGTC_2414 st077232 92.9 µM 2.0164313286893 0.0202979782604194 no 117 0.0218774461459457 232 729801 SGTC_715 0868-0130 184 µM 2.01427305385239 0.0204063181498513 no 118 0.02199043671195 175 2876258 SGTC_1132 3456-3614 2.5 µM 2.00043995665415 0.0211124034521975 no 119 0.0227263887114907 303 3125502 SGTC_1597 7-benzyloxygramine 47.5 µM 1.99818551974701 0.0212294137390451 no 120 0.0228482754086166 420 260807 SGTC_2024 5144227 134 µM 1.99170599393091 0.0215687733579483 no 121 0.0232016628431297 253 3475211 SGTC_2396 5342950 42.78 µM 1.98128793309744 0.0221240177796029 no 122 0.0237794964181755 294 1886677 SGTC_3100 9120536 49.47 µM 1.97689350028392 0.0223618167597031 no 123 0.0240268348406683 143 16421196 SGTC_1888 azatryptophan 97.5 µM 1.9761864152939 0.0224002803836106 no 124 0.0240668339543473 179 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_628 1636-0253 16 µM 1.97234795422061 0.0226100578761704 no 125 0.0242849494219398 261 4456143 SGTC_1967 st070177 51.4 µM 1.97024721579935 0.0227255658637905 no 126 0.0244050223274497 191 5729214 SGTC_2311 7694451 200 µM 1.96650043031595 0.0229328154408726 no 127 0.0246204163344023 234 2163142 SGTC_1021 4476-0760 85.3 µM 1.96088511277305 0.0232464006232807 no 128 0.024946213171125 244 746768 SGTC_3253 9135987 49.47 µM 1.95794316096209 0.0234121286023971 no 129 0.0251183412995498 169 4182430 SGTC_3168 9103419 49.47 µM 1.95502082103778 0.0235777349149758 no 130 0.0252903063912154 112 16649256 SGTC_1558 st069300 45.6 µM 1.95413933607493 0.0236278808647656 no 131 0.0253423706061582 156 24208000 SGTC_761 k216-0224 480 µM 1.94837103939764 0.0239582466071834 no 132 0.0256852912522037 230 1340404 SGTC_2741 miltefosine 3.04 µM 1.94807882491904 0.0239750853029856 no 133 0.0257027660432717 170 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_196 k015-0023 18.111 µM 1.93953905783661 0.0244715945601162 no 134 0.0262178666949458 237 5211998 SGTC_636 0kpi-0074 126 µM 1.93663901015761 0.024642156961778 no 135 0.0263947429453269 217 616434 SGTC_2731 amoxapine 43.43 µM 1.93033788847426 0.0250161890036611 no 136 0.0267824926912025 99 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2687 chenodiol 100 µM 1.93009810610538 0.0250305158834092 no 137 0.0267973415413397 217 5702181 A cholesterol synthesis inhibitor. SGTC_3251 9135047 49.47 µM 1.92727307278813 0.0251998287727533 no 138 0.026972803762728 168 17682963 SGTC_2973 9094665 17.96 µM 1.92183877362635 0.0255282222272231 no 139 0.0273130239049805 289 25237061 YIL048W NEO1 SGTC_597 k018-0003 82.8 µM 1.91192477529643 0.02613655583745 no 140 0.0279429216903865 243 6786234 SGTC_1672 st016598 6.51 µM 1.90742676231391 0.0264165304931249 no 141 0.0282326732735007 300 4665860 YNL267W PIK1 SGTC_1374 2889-5571 141 µM 1.89153331505932 0.0274259533381165 no 142 0.0292765940574232 295 2853281 SGTC_469 w7 172 µM 1.88916498707387 0.0275790888684351 no 143 0.0294348623433989 151 45115570 A P450 inhibitor. SGTC_1748 st037455 53.6035 µM 1.88753609978197 0.0276848254977197 no 144 0.029544127797548 288 580690 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.88714937862761 0.0277099784521324 no 145 0.0295701183752713 296 676296 Flavone; oxidizing agent. SGTC_1734 st037168 69.4 µM 1.8860505898254 0.0277815493561862 no 146 0.0296440688499868 267 708907 SGTC_566 0958-0068 16.5 µM 1.88524420036774 0.0278341724262217 no 147 0.0296984379137139 221 6815365 SGTC_1274 0865-0114 173 µM 1.88130998831057 0.0280921020939278 no 148 0.0299648815442103 254 870624 SGTC_933 2914-0560 114 µM 1.87332383395561 0.0286218023964073 no 149 0.0305118402996634 283 463887 SGTC_3173 9105693 49.47 µM 1.87283368389794 0.0286545815057112 no 150 0.030545677508756 278 17096658 SGTC_1343 1487-0095 224 µM 1.86684375990964 0.0290576896501589 no 151 0.0309617047645958 226 4560101 YGL055W OLE1 SGTC_290 2043-6722 48.1 µM 1.86619127434312 0.0291018836502483 no 152 0.0310073047186373 244 773758 YLR208W SEC13 SGTC_1948 st076329 66.6 µM 1.85437273370477 0.0299120887500786 no 153 0.0318429264514987 248 24208413 SGTC_1879 gemcitabine 100 µM 1.85053658405628 0.0301790592488502 no 154 0.0321181251214451 252 60750 A nucleoside analog which inhibits DNA replication. SGTC_497 capsazepine 133 µM 1.84659843517501 0.0304551798083237 no 155 0.0324026805819435 239 2733484 A calcium channel blocker. SGTC_1070 indatraline 8.81 µM 1.84457120644666 0.0305981315378626 no 156 0.0325499693685473 291 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_519 k048-0011 62.8 µM 1.84372140871815 0.0306582208156454 no 157 0.0326118756772321 267 6836379 SGTC_608 k048-0125 159 µM 1.84183325241338 0.0307920823443383 no 158 0.0327497722331797 273 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.83836787969836 0.0310390201086272 no 159 0.033004107434074 272 688751 SGTC_1479 0549-0158 134 µM 1.83512909403723 0.0312712907669584 no 160 0.0332432820139074 294 5440202 SGTC_880 0833-0487 87.2 µM 1.82072299250679 0.0323219117241355 no 161 0.0343244876378155 268 76075 SGTC_699 0375-0592 111 µM 1.80633396214701 0.0334001950285136 no 162 0.0354330949778674 254 762578 SGTC_2784 7567673 72.73 µM 1.80009550222305 0.0338768101161274 no 163 0.0359227798453434 331 3471247 SGTC_2642 cholecalciferol 100 µM 1.79765552215492 0.0340647389680015 no 164 0.0361158069498162 243 9821465 A vitamin D precursor, similar to steriods. SGTC_1564 D-Arginine 115 µM 1.79761265355129 0.0340680483830453 no 165 0.0361192058673821 303 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1310 1188-0297 994 nM 1.79571964615691 0.0342144505363931 no 166 0.0362695578701155 303 1588352 SGTC_2596 sinensetin 100 µM 1.7954979456159 0.0342316302810723 no 167 0.0362871998900766 280 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2295 7971645 200 µM 1.78585367809981 0.0349858627900868 no 168 0.0370614764052548 306 2978226 YKL099C UTP11 SGTC_2821 7996764 71.43 µM 1.78532961217964 0.0350272351592723 no 169 0.0371039341868727 338 2987135 SGTC_495 decylubiquinone 155 µM 1.77985273455183 0.0354620141206179 no 170 0.0375500323321169 290 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.76478603877491 0.0366809486098312 no 171 0.03879986595953 325 1273210 SGTC_616 4092-0450 108 µM 1.76460311337275 0.0366959557026751 no 172 0.0388152459358989 321 787165 SGTC_8 0354-0001 70 µM 1.75696640826823 0.0373269612789504 no 173 0.0394617675329185 413 4993152 SGTC_1643 st009866 20.2 µM 1.75333437680725 0.0376301641214783 no 174 0.0397723140060233 248 3156273 YOR207C RET1 SGTC_1250 0485-0349 40.2 µM 1.74728274772052 0.0381398195637407 no 175 0.0402941520970907 323 6842794 YDL195W SEC31 SGTC_536 3852-0578 10.6 µM 1.74710839899875 0.0381545858705908 no 176 0.0403092683833875 283 2869208 SGTC_2272 7805186 180 µM 1.74016228355366 0.0387466843489214 no 177 0.0409152631319524 272 2956062 YPR165W RHO1 SGTC_549 1661-1316 519 µM 1.72942194946925 0.0396769236307393 no 178 0.0418668022098396 320 2857282 SGTC_1902 st060212 70.5 µM 1.72898869869585 0.0397148260243124 no 179 0.0419055588720743 313 688944 SGTC_2755 lomerizine 42.69 µM 1.72850217194295 0.0397574242859428 no 180 0.0419491159836596 329 3949 A calcium channel blocker. SGTC_1693 xanthone 101.9 µM 1.71248183373599 0.0411809744534258 no 181 0.0434039547984265 336 7020 An insecticide. SGTC_1612 st002233 45.4 µM 1.71059633723578 0.0413512024924315 no 182 0.0435778278062321 313 1035021 SGTC_2935 9038016 29.96 µM 1.71050119407307 0.0413598073834737 no 183 0.0435866164082862 344 6463195 SGTC_1506 4226-2149 212 µM 1.69457793806079 0.0428205040207442 no 184 0.0450777575900743 385 991114 SGTC_101 0490-5701 117.494 µM 1.68183048061933 0.0440196851360852 no 185 0.0463008581800459 269 4661669 SGTC_2911 7942208 15.64 µM 1.68156006666688 0.044045413927424 no 186 0.0463270898096071 291 1243384 SGTC_3278 9139605 49.47 µM 1.68044930566004 0.0441512255625088 no 187 0.0464349648834957 321 7958859 SGTC_2429 5902844 64.44 µM 1.67521240614556 0.0446528588931564 no 188 0.0469462821426345 370 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2674 ligustilide 100 µM 1.67289170853564 0.0448766173851984 no 189 0.0471743081840849 283 5319022 A signalling regulator. SGTC_1042 0350-0096 82 µM 1.66730310422445 0.0454191683535792 no 190 0.0477270748558563 333 3122515 SGTC_2022 5136654 200 µM 1.66587995957961 0.0455581690341331 no 191 0.0478686629632542 354 1713771 SGTC_3284 9108171 64.8615 µM 1.65763508641834 0.0463702021385685 no 192 0.048695571650464 295 8687505 SGTC_2861 9024595 19.48 µM 1.65718985847768 0.0464143809711524 no 193 0.0487405481358642 211 16482810 SGTC_43 0570-0105 72.5 µM 1.65336626157184 0.0467951793061027 no 194 0.0491281724684695 496 1114046 YDL195W SEC31 SGTC_1312 1218-2183 165 µM 1.64693780800601 0.0474410446294822 no 195 0.0497854148354341 343 6744073 SGTC_114 0364-0001 490.298 µM 1.6412251452583 0.0480209702335962 no 196 0.0503753439330417 377 4003655 SGTC_1234 0326-0494 15.5 µM 1.6411822877173 0.0480253422981071 no 197 0.0503797906597875 310 1547813 SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.62906360270248 0.0492744535070903 no 198 0.0516497776578954 311 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1851 st056236 18.9 µM 1.62670954886929 0.0495200762605748 no 199 0.0518993998772405 348 5393171 SGTC_2758 dehydroepiandrosterone 69.35 µM 1.62638698416389 0.0495538087622607 no 200 0.0519336789688855 385 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_426 0988-0037 14.6 µM 1.62381810658551 0.0498231065070823 no 201 0.0522073172573206 422 5383008 SGTC_1304 1165-0502 251 µM 1.62247467345372 0.0499644039887453 no 202 0.0523508758327659 414 767425 SGTC_1511 0906-3109 28.5 µM 1.61984777546116 0.0502416149352442 no 203 0.0526324903105738 485 2882180 SGTC_170 4197-0004 226 µM 1.61593605677074 0.050656680660087 no 204 0.053054069439329 309 218692 SGTC_2916 7875993 68.79 µM 1.61556276481585 0.0506964323573917 no 205 0.053094439935738 370 1299250 SGTC_2958 9077254 16.72 µM 1.61397818590667 0.050865450098831 no 206 0.0532660789933292 337 16457351 SGTC_2444 5485484 36.41 µM 1.6137788669885 0.0508867420069618 no 207 0.0532877000063352 381 6790631 SGTC_273 hydroxyurea 18.1 mM 1.60982322136888 0.0513107667167703 no 208 0.0537182271243602 426 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1771 st048882 4.1505 µM 1.60779232141176 0.0515295580751364 no 209 0.0539403353618973 347 4580403 SGTC_2640 pentamidine 10.38 µM 1.60564423463727 0.0517617807434551 no 210 0.0541760502117182 406 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_295 k015-0027 31 µM 1.60392413008546 0.0519483347476444 no 211 0.0543653886095717 338 3887424 SGTC_190 3970-0790 3.722 µM 1.60155475567164 0.052206179663763 no 212 0.0546270512943913 329 2832352 SGTC_2968 9090663 33.37 µM 1.58814129345579 0.053685104661652 no 213 0.0561271962987176 377 25236811 SGTC_735 3076-0345 636 µM 1.58337940204344 0.054218047129864 no 214 0.0566675074509412 429 2888990 SGTC_3049 9092223 49.47 µM 1.58305280553414 0.0542547521011608 no 215 0.056704714578736 342 8623917 SGTC_568 1193-0097 7.48 µM 1.58251015650679 0.0543157818847744 no 216 0.0567665777870118 464 3646150 SGTC_132 0417-1715 25.805 µM 1.58049371734382 0.0545430395589427 no 217 0.0569969222784253 388 6769098 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.57445929748233 0.0552276279920723 no 218 0.057690652155984 393 115019 SGTC_235 0330-0087 5 mM 1.57400333154908 0.0552796306317843 no 219 0.0577433396152553 416 46494818 YHR062C RPP1 SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.57267600705992 0.0554312313511161 no 220 0.057896929083218 275 77254 SGTC_1799 st045822 46.1415 µM 1.56940861005259 0.0558058166744569 no 221 0.0582763795541424 359 3674992 SGTC_910 3454-3003 490 µM 1.56165003461979 0.056703288173352 no 222 0.0591852277639566 427 820824 SGTC_220 paclitaxel 373.376 µM 1.55815599669032 0.0571111556265208 no 223 0.059598136600154 311 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1446 4239-0190 62 µM 1.55506356161503 0.0574740663174353 no 224 0.0599654660545773 442 1340085 SGTC_515 4092-1064 102 µM 1.55314879827156 0.0576996799183513 no 225 0.0601937951495525 462 717353 SGTC_1433 4060-0023 7.6 µM 1.54582644438012 0.0585688911162465 no 226 0.0610732443274454 405 3840627 SGTC_397 arbidol 50 µM 1.54117989904054 0.0591257763839146 no 227 0.0616365041254283 412 131410 A RNA synthesis inhibitor. SGTC_2237 6667747 47.222 µM 1.54096384275745 0.0591517712782865 no 228 0.0616627930874843 357 729940 YDL015C TSC13 SGTC_723 4182-0001 115 µM 1.53622123267199 0.059724641085286 no 229 0.0622420650996226 383 744821 YLR208W SEC13 SGTC_3180 9109287 49.47 µM 1.53539953169389 0.0598243364211022 no 230 0.0623428593481033 346 18891271 SGTC_2006 4011487 200 µM 1.53262338006626 0.0601621258193681 no 231 0.0626843387187054 462 45595294 SGTC_57 miconazole 162.5 nM 1.52993487279153 0.0604906724856788 no 232 0.0630164251905645 374 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.52795708898204 0.0607332607716459 no 233 0.0632615962055177 384 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_695 3505-6186 243 µM 1.52700132949657 0.0608507633644658 no 234 0.06338034038744 406 1819379 SGTC_1418 3966-3099 2.4 µM 1.52539962232398 0.0610480782696084 no 235 0.0635797264553106 437 740335 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.52533622531357 0.0610558984480393 no 236 0.063587628365461 398 7104 SGTC_1144 3486-0183 12.5 µM 1.52472098773167 0.0611318302054008 no 237 0.06366435231181 433 6744069 SGTC_2167 5876490 200 µM 1.5246634457912 0.0611389357231742 no 238 0.063671531830675 420 686534 SGTC_230 MPP+ 141.667 µM 1.51814725563084 0.0619477652280902 no 239 0.0644886402784129 395 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1891 st059073 26.2 µM 1.51570271914716 0.0622533411672932 no 240 0.0647972698896471 427 688754 SGTC_592 k241-0073 46.5 µM 1.51519193317532 0.0623173395175933 no 241 0.0648619026780444 430 4230158 SGTC_312 4092-0653 6.84 µM 1.51307233027184 0.0625834611493947 no 242 0.065130643571231 519 1148278 SGTC_1210 3013-0140 750 nM 1.51299256052858 0.0625934937175444 no 243 0.0651407742888029 415 905973 SGTC_605 1315-0399 119 µM 1.50205675804059 0.063980784655191 no 244 0.0665412255969095 456 24020461 SGTC_1101 ebselen 5.29 µM 1.50202409199106 0.0639849641212008 no 245 0.0665454434870885 425 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_704 1310-0270 142 µM 1.49822355774423 0.0644726752116223 no 246 0.0670375884934518 458 5718033 SGTC_1067 clotrimazole 1.36 µM 1.49700502596064 0.0646296556708457 no 247 0.0671959751468563 452 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2634 4'-methoxyflavone 100 µM 1.49661779324585 0.064679604023482 no 248 0.0672463687940354 408 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2081 5214970 32.255 µM 1.4910200686218 0.0654049966057192 no 249 0.0679781130329014 413 2063512 SGTC_1659 st012954 42.1 µM 1.48914079058112 0.0656499364534468 no 250 0.0682251492031561 394 24207262 SGTC_2695 st077686 51.995 µM 1.48818994679345 0.0657741374204621 no 251 0.0683504038713862 396 2876092 SGTC_80 0159-0065 512.242 µM 1.48539254065241 0.0661405960297006 no 252 0.0687199352464187 289 1548079 SGTC_2038 4100038 30.985 µM 1.48417572181735 0.0663004913635362 no 253 0.0688811544259836 443 3596803 SGTC_1161 k007-0610 110 µM 1.48123950948123 0.0666875551525905 no 254 0.0692713806643188 551 5843850 SGTC_3174 9107204 49.47 µM 1.47677432430292 0.0672795233400156 no 255 0.0698680706484309 436 3938802 SGTC_2094 5332512 191.667 µM 1.47354334478228 0.0677103950184721 no 256 0.0703022925998611 447 755774 SGTC_1236 0330-0013 258 µM 1.4721094449736 0.0679022962653886 no 257 0.0704956626908363 403 4617066 SGTC_1634 st006576 41 µM 1.47180625793008 0.0679429260422625 no 258 0.0705366016203998 426 3915356 SGTC_3132 9126706 49.47 µM 1.47076092980881 0.0680831533142325 no 259 0.0706778909710341 400 850858 SGTC_3165 9101544 49.47 µM 1.46836179261195 0.0684058343064335 no 260 0.0710029870928756 449 5002184 SGTC_2873 9040596 71.43 µM 1.46547205180525 0.0687960659851646 no 261 0.0713960860305768 451 6463863 SGTC_2650 prasterone 100 µM 1.46531275983385 0.0688176266444585 no 262 0.0714178034099521 330 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2381 9035592 200 µM 1.46504003279036 0.0688545531854279 no 263 0.0714549979504055 374 4749657 SGTC_1630 st005209 31.3 µM 1.45857797864979 0.0697339747644137 no 264 0.0723406491426942 481 3367314 SGTC_1114 scopoletin 1.73284 µM 1.45805270598024 0.0698058374085245 no 265 0.072413007948673 404 5280460 A coumarin with genotoxic properties. SGTC_1723 st034307 2.5525 µM 1.44733053130331 0.0712852280650314 no 266 0.0739021859826108 444 867466 SGTC_3052 9092717 49.47 µM 1.44639178229734 0.0714158891223949 no 267 0.0740336727275509 453 25237534 SGTC_1111 tnp00062 510.699 nM 1.44139213656939 0.0721148699633845 no 268 0.0747369652673931 442 676306 SGTC_1686 st019653 115.5 µM 1.43635480185612 0.0728244115709119 no 269 0.0754507037059807 430 97252 SGTC_3218 9131285 49.47 µM 1.43616566508005 0.0728511564634776 no 270 0.0754776032725958 538 17156417 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.43554518875016 0.072938947739527 no 271 0.0755659004849912 518 5024745 SGTC_2947 9072639 7.68 µM 1.43461164076412 0.0730711881141797 no 272 0.0756988977870983 506 16488146 SGTC_897 1000-0139 31.4 µM 1.43343697257137 0.073237844607904 no 273 0.0758664993761183 445 6151020 SGTC_3098 9119039 49.47 µM 1.42306723871046 0.0747216922495482 no 274 0.0773583321967175 461 17161528 SGTC_2898 9056270 58.44 µM 1.42287050427892 0.0747500639008221 no 275 0.0773868490717907 387 19154699 SGTC_2994 9053520 71.4286 µM 1.42283935390015 0.0747545569423054 no 276 0.0773913650860186 465 4647384 SGTC_1966 st070145 16.1 µM 1.4184420559469 0.0753908806000627 no 277 0.078030872241822 463 3748532 SGTC_275 trichlorophene 5.69 µM 1.41841800582386 0.0753943721583149 no 278 0.0780343808860497 655 62616 SGTC_2836 9010338 19.48 µM 1.41193897765911 0.0763394832243126 no 279 0.0789839648371146 441 2994051 SGTC_2244 6635614 200 µM 1.410160120263 0.076600540141916 no 280 0.0792462042057795 333 836499 SGTC_2643 anethole 100 µM 1.40694733784669 0.0770737530872813 no 281 0.0797215025610553 500 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_374 0880-0231 82.3 µM 1.40616572405397 0.0771892128100065 no 282 0.0798374598125593 487 6833587 SGTC_2739 tacrine 100.86 µM 1.40521936093795 0.0773291850780948 no 283 0.0799780293198383 428 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1266 0828-0227 32.9 µM 1.40110059053854 0.0779406200667768 no 284 0.0805919975251486 451 3913820 SGTC_1889 st059080 5.18 µM 1.40106469422837 0.0779459649834382 no 285 0.0805973640453484 508 176925 Isolated from Daphnopsis sellowiana. SGTC_359 0081-0058 15.9 µM 1.40101781828054 0.0779529451734516 no 286 0.0806043724344207 469 3494159 SGTC_1962 st076595 64.5 µM 1.40011380556825 0.0780876524293197 no 287 0.0807396207718852 485 279619 SGTC_1028 k015-0029 4.8 µM 1.39958145389724 0.0781670609134131 no 288 0.080819345443314 517 4588309 SGTC_2121 5257820 149.641 µM 1.39830948194033 0.0783570431985903 no 289 0.0810100758633056 506 791256 SGTC_3332 9141069 11.198 µM 1.3961465931048 0.0786808967725301 no 290 0.0813351777364264 419 17332883 SGTC_1220 1838-0075 193 µM 1.39406666431031 0.0789932843467824 no 291 0.0816487372955648 495 5529645 SGTC_2 0422-0095 29 µM 1.39094816487238 0.0794634152547218 no 292 0.0821205728924378 375 6790840 SGTC_2031 5180455 200 µM 1.39055186802625 0.0795233105074811 no 293 0.0821806802472713 437 29949 SGTC_46 0329-0187a 2.197 µM 1.3884001555001 0.079849111066959 no 294 0.0825076145300326 599 46494817 SGTC_2180 6301957 200 µM 1.3865333888558 0.0801325836169085 no 295 0.0827920461079505 457 845462 SGTC_1269 0831-0796 3.05 µM 1.38640683537442 0.0801518285354756 no 296 0.0828113552135642 482 927758 SGTC_2976 9009005 19.48 µM 1.38460735923907 0.0804258520325271 no 297 0.0830862799839847 477 2993148 SGTC_3029 9088683 49.47 µM 1.3842601093262 0.0804788124858056 no 298 0.0831394119009156 482 25236615 SGTC_3107 9121808 49.47 µM 1.38390948269277 0.0805323146637745 no 299 0.0831930864018126 376 662681 SGTC_787 4152-0075 138 µM 1.38195191481898 0.0808315141335536 no 300 0.0834932330116334 487 9566539 SGTC_1422 4031-0024 15.5 µM 1.38137768962588 0.0809194391241791 no 301 0.0835814310135106 480 782427 SGTC_261 5-fluorouridine 15.376 µM 1.37890681099361 0.0812986023383888 no 302 0.0839617439646251 491 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2170 morpholine 200 µM 1.37780761114218 0.081467707730065 no 303 0.0841313477424043 469 121171 Reacts with secondary amines. SGTC_51 1013-0126 23.419 µM 1.37694258489424 0.0816009733185837 no 304 0.0842649998571349 464 1627850 SGTC_109 0132-0036 33.701 µM 1.37585394667214 0.0817689219889249 no 305 0.0844334278429528 352 67274 A color developer. SGTC_122 0236-0016 402.397 µM 1.37208637767812 0.082352171704926 no 306 0.085018274817987 568 6808838 SGTC_776 4476-4378 112 µM 1.36963947300421 0.0827326465976321 no 307 0.0853997356635077 460 2892008 SGTC_1034 k072-0165 12.7 µM 1.36747439452647 0.0830704013825164 no 308 0.0857383288967486 526 5835461 SGTC_1056 3448-1962 115 µM 1.36631957954361 0.0832509774274113 no 309 0.0859193390727318 467 715507 SGTC_2208 7283366 200 µM 1.36583873043516 0.0833262537790756 no 310 0.0859947935001258 499 898663 SGTC_1277 0873-0036 22 µM 1.36519192783311 0.0834275906397714 no 311 0.0860963673963767 542 5965735 SGTC_3224 9130643 49.47 µM 1.36382810028269 0.0836415698739757 no 312 0.0863108370268481 477 17644395 SGTC_1657 st012939 43.4 µM 1.36230313404674 0.0838813191502908 no 313 0.0865511194897387 460 24207257 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 1.35901663208419 0.0843997643683436 no 314 0.0870706591943505 612 6708739 YPR165W RHO1 SGTC_2379 9035213 200 µM 1.35826560567403 0.0845185754662274 no 315 0.0871897098951509 548 646551 SGTC_2268 7933382 153.85 µM 1.35781269654257 0.0845902855410353 no 316 0.0872615625684574 583 935025 YOR257W CDC31 SGTC_2119 5528445 120.635 µM 1.35612443751949 0.0848579933621255 no 317 0.0875297893530476 492 791935 SGTC_491 tetrandrine 80.3 µM 1.35530726725232 0.0849878002504005 no 318 0.0876598402946785 441 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2045 5106652 78.05 µM 1.35480318297229 0.0850679478542555 no 319 0.0877401361191481 488 673349 SGTC_2719 novobiocin 32.65 µM 1.35350442141011 0.0852747072899931 no 320 0.087947269245769 409 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_192 3455-0609 60.9 µM 1.35273750261357 0.0853969754245382 no 321 0.0880697524904453 499 3769639 SGTC_3222 9128301 49.47 µM 1.34994321632606 0.0858435731118632 no 322 0.0885170989410394 505 4911358 SGTC_321 4534-3890 65.3 µM 1.3461558858612 0.0864516716359115 no 323 0.0891261242628587 511 699746 SGTC_1230 0170-0365 3.77 µM 1.34001486663903 0.0874445175465054 no 324 0.0901202558411951 681 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1209 2323-2347 50.3 µM 1.3363367541745 0.0880432355177445 no 325 0.0907196141784555 492 5412760 SGTC_2782 7736369 71.43 µM 1.33584281271818 0.0881238708442622 no 326 0.0908003280556494 549 2950836 YOL077C BRX1 SGTC_989 1501-0895 10.3 µM 1.33577459903536 0.0881350109681041 no 327 0.0908114788884995 504 2830112 SGTC_1214 0358-0031 63.7 µM 1.33529726103024 0.0882129954474797 no 328 0.0908895373623113 529 4301366 SGTC_2205 7238770 200 µM 1.33528457066532 0.0882150694210909 no 329 0.0908916132805696 475 279867 SGTC_1933 st074711 15.9 µM 1.33481799556214 0.0882913465576148 no 330 0.0909679611029591 566 17250958 SGTC_3114 9122766 49.47 µM 1.3341308053387 0.0884037800320039 no 331 0.0910804958080014 494 17176985 SGTC_2931 9014674 55.67 µM 1.33382812710319 0.0884533360536728 no 332 0.0911300953288755 506 2996810 SGTC_3288 9119690 36.221 µM 1.32794594885813 0.0894205099455635 no 333 0.0920979818468367 458 17595618 YKL019W RAM2 SGTC_1181 1222-0449 220 µM 1.32506567583949 0.0898969563842858 no 334 0.0925746846588199 521 658318 SGTC_2703 st077852 53.4 µM 1.3250059590863 0.089906854482203 no 335 0.092584587424821 499 6281836 SGTC_281 1672-3440 14.9 µM 1.32387027936465 0.0900952484735065 no 336 0.0927730651753991 570 6833000 SGTC_1865 st057639 52.2 µM 1.32130150264436 0.0905224556686003 no 337 0.0932004265789108 530 688818 SGTC_1943 st076331 65.2 µM 1.32089456732444 0.0905902698826411 no 338 0.0932682607262759 551 24208415 SGTC_2746 daunorubicin 9.88 µM 1.31943944798668 0.0908330684761407 no 339 0.0935111205120683 359 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3299 9121982 43.1275 µM 1.31870299307158 0.0909561358938364 no 340 0.0936342128834114 544 17594604 YPL160W CDC60 SGTC_1241 0364-0022 50.8 µM 1.31770580298456 0.0911229712905344 no 341 0.0938010756121257 560 4563895 SGTC_807 1315-0151 48 µM 1.31448403111527 0.0916635425363605 no 342 0.0943416842571469 610 4011080 SGTC_222 nsc-310342 10.666 µM 1.31239050775105 0.0920160797972235 no 343 0.0946942039950054 394 432556 SGTC_2458 5808907 16.39 µM 1.30884139844517 0.0926160214069658 no 344 0.0952940402480989 560 2731747 SGTC_2211 7117706 200 µM 1.30355112092204 0.0935156537190171 no 345 0.0961933377824395 507 822771 SGTC_1662 st014054 52 µM 1.30311489467425 0.0935901227245107 no 346 0.0962677696392711 498 2838777 SGTC_641 4092-0595 30 µM 1.30247485827547 0.0936994637920516 no 347 0.0963770535609224 563 786260 SGTC_2162 5663267 200 µM 1.30067057536984 0.0940082073734929 no 348 0.0966856191113767 567 6456493 SGTC_251 melphalan 456.522 µM 1.29300210382606 0.0953287911346031 no 349 0.0980051657338417 619 460612 A DNA alkylator. SGTC_2351 9026858 72.31 µM 1.29258373768098 0.0954012286688523 no 350 0.0980775335518547 502 1409300 SGTC_2425 5628681 7.85 µM 1.29212665959248 0.0954804152456161 no 351 0.0981566424009849 636 5714958 SGTC_578 3460-0051 92 µM 1.29072305139995 0.0957238859649145 no 352 0.0983998642348342 616 2876744 SGTC_168 3970-0862 530.542 µM 1.29057714703955 0.0957492208066101 no 353 0.0984251723213392 736 3135186 SGTC_1961 st076550 68.7 µM 1.28942763058431 0.0959489954597657 no 354 0.0986247303532936 494 1579337 SGTC_2899 9053889 58.44 µM 1.28853333292523 0.0961046274731831 no 355 0.0987801866775799 518 6470052 SGTC_117 lucigenin 22.078 µM 1.28144864900453 0.0973441180844583 no 356 0.100018062872235 622 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_3095 9117207 49.47 µM 1.28106336491977 0.097411859591421 no 357 0.100085705200019 492 17015229 SGTC_83 0170-0301 39.027 µM 1.28042283543869 0.0975245554342491 no 358 0.10019823354912 424 3089716 SGTC_2294 7971431 200 µM 1.2762238396133 0.0982657026653916 no 359 0.100938201844727 492 5741572 SGTC_1403 3909-7815 62.9 µM 1.2741573603745 0.0986319593952306 no 360 0.101303826630618 507 6615483 SGTC_181 1447-1644 8.07 µM 1.27232243849535 0.0989580122687937 no 361 0.101629289642392 566 534600 SGTC_1380 2291-0730 164 µM 1.27126929112517 0.0991455050369595 no 362 0.101816431624147 518 2999191 SGTC_2002 4023503 131 µM 1.26986533104933 0.0993958571416252 no 363 0.102066302183059 694 4736863 YCR052W RSC6 SGTC_1936 st074407 74.3 µM 1.26956914269751 0.0994487319925813 no 364 0.102119073410846 605 809813 SGTC_143 4032-1194 15.74 µM 1.26921484405712 0.0995120075581743 no 365 0.102182224091555 663 1806963 SGTC_3130 9127414 49.47 µM 1.26571180346456 0.100139213413433 no 366 0.102808140449968 548 1494646 SGTC_656 4090-1979 187 µM 1.26537071558978 0.100200437718601 no 367 0.102869233876275 613 22330961 SGTC_1883 5-benzylidenerhodanine 20 µM 1.2652443210509 0.100223132116913 no 368 0.102891879535434 639 1273210 SGTC_693 4161-2696 114 µM 1.26515133650409 0.100239830077979 no 369 0.102908541557637 501 805759 SGTC_2594 a-mangostin 100 µM 1.26350596864721 0.100535637587835 no 370 0.10320370148109 610 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2913 7966556 36.57 µM 1.25958341694579 0.101243409538138 no 371 0.103909840412825 532 2976516 SGTC_1025 k007-0731 70 µM 1.25771158008823 0.101582434225694 no 372 0.104248041379184 552 6256118 SGTC_291 SEC14.278 35.5 µM 1.25500102898739 0.102074829976042 no 373 0.104739193212756 607 1068044 SGTC_1808 st050063 61.5 µM 1.25486730859551 0.102099166346977 no 374 0.104763466648554 553 4011993 SGTC_3244 9134489 49.47 µM 1.25427189399691 0.102207579754074 no 375 0.104871598031906 572 16584271 SGTC_2206 7254556 146.969 µM 1.25340952243248 0.102364749264367 no 376 0.105028353874281 519 4398905 SGTC_274 sirtinol 40.1 µM 1.25306783259561 0.102427071737198 no 377 0.105090510740746 572 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2324 6149169 200 µM 1.25228200993149 0.102570506439644 no 378 0.10523356090977 539 2888231 SGTC_557 1315-0110 16.2 µM 1.24961632130235 0.103058157166994 no 379 0.105719869035814 590 6833801 SGTC_3016 9080866 49.47 µM 1.24774033562791 0.103402350816447 no 380 0.106063082383294 608 17066299 SGTC_1467 k284-1082 293 µM 1.2427870626584 0.104315153710048 no 381 0.106973155580323 615 3334705 SGTC_360 0957-0399 1.01 µM 1.2367717528506 0.105431506290675 no 382 0.108085915830574 621 6752301 YPR165W RHO1 SGTC_3136 9095672 49.47 µM 1.23395207497922 0.105957761290321 no 383 0.108610381535414 519 17217380 SGTC_259 usnic acid 108.925 µM 1.23142319331763 0.106431355452851 no 384 0.109082313417021 612 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_244 nsc-207895 1.295 µM 1.22968192217534 0.106758337836757 no 385 0.109408119510825 478 42640 SGTC_2822 7994718 71.43 µM 1.22967246564635 0.106760115595966 no 386 0.109409890811051 518 1018011 SGTC_2005 4024620 188 µM 1.22717005734353 0.10723130136336 no 387 0.109879340469922 590 236743 SGTC_1625 st003711 30.1 µM 1.226964238061 0.107270122307199 no 388 0.109918016231566 574 24207034 YER133W GLC7 SGTC_538 2922-0838 53.3 µM 1.2259424750234 0.107462993846724 no 389 0.110110161646203 678 777039 SGTC_1117 retinoic acid 1.10837 µM 1.22541236903975 0.107563156910279 no 390 0.110209944449513 650 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1907 st060210 83.7 µM 1.22467784320655 0.107702056091787 no 391 0.110348312738092 659 688793 SGTC_1642 st009582 77.7 µM 1.22260135977283 0.108095418969271 no 392 0.110740149646808 565 6739311 SGTC_2890 9046729 58.44 µM 1.22180812780002 0.108245959184157 no 393 0.11089009710685 532 903329 SGTC_2709 st078560 56 µM 1.22041951522005 0.108509854394162 no 394 0.111152941555567 600 17250903 SGTC_34 0469-0683 81.75 µM 1.21617959251861 0.109318482605941 no 395 0.11195825795688 593 3690923 SGTC_1583 clindamycin 39.6 µM 1.21606343996724 0.109340695707734 no 396 0.111980378132612 567 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.21602706999644 0.109347651794994 no 397 0.111987305098481 581 6708760 SGTC_1726 st035556 14.5795 µM 1.21462417147475 0.109616211544916 no 398 0.112254732750945 661 5919439 SGTC_1146 3579-1023 7 µM 1.21378223574725 0.109777612251269 no 399 0.112415445796525 673 X1146 SGTC_2639 lactacystin 53 µM 1.21071481091862 0.110367086246286 no 400 0.113002362014377 646 3870 A proteasome inhibitor. SGTC_3264 9137442 49.47 µM 1.21066071377867 0.110377502544105 no 401 0.113012732463763 578 17015726 SGTC_881 0833-0569 170 µM 1.21000271421724 0.110504255498187 no 402 0.113138925694692 628 5418700 SGTC_2522 biochanin a 4.94 µM 1.20644590991178 0.111191222839271 no 403 0.11382280159491 578 5280373 A possible chelator. SGTC_1692 fluoroquinolonic acid 71 µM 1.20584663139089 0.111307268882066 no 404 0.113938315801942 608 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_417 st075190 100 µM 1.20185430838497 0.112082567006895 no 405 0.114709989921275 651 222757 SGTC_1563 conessine 56.1 µM 1.20040215569037 0.112365526317845 no 406 0.114991596037113 719 441082 An anti-amoebic, histamine inhibitor. SGTC_898 1000-0849 28.3 µM 1.19869358014967 0.112699104034821 no 407 0.115323557624532 631 6751807 SGTC_623 k072-0108 16.9 µM 1.19723268564128 0.112984885494346 no 408 0.115607936630256 625 5382803 SGTC_2991 9074669 71.4286 µM 1.1915159339445 0.114108172763206 no 409 0.116725552591494 694 17333109 SGTC_1015 4130-4525 82 µM 1.18907133831735 0.114590932708787 no 410 0.117205797932796 626 1363237 SGTC_936 3005-4620 401 µM 1.18903409299913 0.114598299157371 no 411 0.117213125653683 702 777207 SGTC_1579 chlormadinone acetate 49.4 µM 1.18862359680504 0.114679510188126 no 412 0.117293909022744 650 45114258 A steroidal progestin. SGTC_2239 6685329 187.64 µM 1.18598863140864 0.115201777072468 no 413 0.117813394580365 625 805680 SGTC_3314 9135860 59.4275 µM 1.18526075336176 0.115346344725972 no 414 0.117957182874228 661 25252478 SGTC_617 3770-0098 35 µM 1.18304284063681 0.115787650838898 no 415 0.118396084643865 596 5962639 SGTC_3024 9090631 49.47 µM 1.18217259610456 0.115961133664365 no 416 0.118568611897366 593 25236383 SGTC_2298 7976326 193.81 µM 1.18020226933656 0.116354599038394 no 417 0.118959888344146 563 2235818 SGTC_2986 9022445 71.43 µM 1.17866049951307 0.116663143393647 no 418 0.119266695251005 627 6459286 SGTC_2443 5493264 126.67 µM 1.17797421990469 0.116800670494354 no 419 0.119403442005978 637 5340055 SGTC_3295 9122362 53.5725 µM 1.17390071521574 0.11761934684124 no 420 0.120217397979952 612 4730473 SGTC_2260 7964312 200 µM 1.17312214930098 0.117776281082418 no 421 0.120373412735889 585 231951 SGTC_3265 9137266 49.47 µM 1.17136506702686 0.118130997651564 no 422 0.120726033758558 573 17224265 SGTC_490 phenamil 164 µM 1.17115852229586 0.118172744099705 no 423 0.120767532013452 524 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2467 5474540 200 µM 1.16736450876066 0.118941439742007 no 424 0.121531598767061 645 5413519 SGTC_1514 1189-1591 158 µM 1.16587487962807 0.119244213077704 no 425 0.121832518393829 681 767698 YMR146C TIF34 SGTC_70 0141-0289 43.283 µM 1.16220244310589 0.119992973643515 no 426 0.122576621260526 852 352408 SGTC_2254 7938975 95.19 µM 1.16187719642056 0.120059446474623 no 427 0.122642675560005 750 2969277 SGTC_1133 3473-0247 50 µM 1.15941432350129 0.120563642600845 no 428 0.123143670532124 666 711311 SGTC_1263 0774-1208 64.8 µM 1.15931846198529 0.120583297344995 no 429 0.123163199538346 745 906585 SGTC_134 0269-0018 6.916 µM 1.15704591988545 0.121049903587581 no 430 0.123626799903086 661 4378915 SGTC_3240 9133527 49.47 µM 1.15648152029985 0.121165984723591 no 431 0.123742127045328 647 17617455 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.15277099662657 0.121931084701499 no 432 0.12450219592249 761 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1378 2093-0007 380 nM 1.15235127863379 0.122017842583386 no 433 0.124588376593752 650 3618014 SGTC_1414 3917-0015 5.4 µM 1.14972011151827 0.122562706229043 no 434 0.125129584103192 629 6618702 SGTC_2555 cholic acid 100 µM 1.14934007676839 0.122641544915683 no 435 0.125207889337147 654 6708657 Influences liver metabolism. SGTC_2118 5526350 200 µM 1.14236794090229 0.124094239598686 no 436 0.126650555654573 681 743594 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.14053100370865 0.124478974441474 no 437 0.127032571831415 713 688801 SGTC_940 3232-1287 54.8 µM 1.14017846098948 0.124552907563715 no 438 0.127105979529936 689 1585493 YIL048W NEO1 SGTC_1735 st034310 56.75 µM 1.1383491412866 0.124937034308689 no 439 0.127487360933531 668 871153 SGTC_1022 4477-0945 21.3 µM 1.13250799409173 0.126169115487132 no 440 0.128710462715928 679 4648966 SGTC_2878 9043973 25.97 µM 1.13183947059913 0.126310666328237 no 441 0.128850965082156 651 6465167 SGTC_2197 6588183 93.1375 µM 1.13000051317919 0.126700611558077 no 442 0.129238004120608 635 884136 SGTC_2390 9097792 176.6 µM 1.12846085429466 0.127027735599884 no 443 0.129562670033326 635 4497149 SGTC_2568 diosmetin 100 µM 1.12495982262071 0.127773769856335 no 444 0.130303029977553 717 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1395 3486-0190 4.35 µM 1.1238025831105 0.128021034133343 no 445 0.130548392709042 717 6748079 SGTC_1246 0422-0085 105 µM 1.11661237560484 0.129564795037683 no 446 0.132080048932673 717 264295 SGTC_183 3914-0051 30.55 µM 1.11413959999723 0.130098675996202 no 447 0.132609651185469 698 1596232 SGTC_127 0180-0333 59.125 µM 1.11384317349183 0.13016277756878 no 448 0.13267323585376 776 771601 SGTC_68 0986-0284 82.829 µM 1.10873331810097 0.131271208877626 no 449 0.133772622076079 600 423278 YIL048W NEO1 SGTC_1059 3448-6867 171 µM 1.10519211626001 0.132043180938862 no 450 0.134538176116502 708 3934407 SGTC_852 0418-0143 439 µM 1.10516742050589 0.132048575513521 no 451 0.134543525501697 784 5369229 SGTC_639 0833-0042 114 µM 1.10472077852896 0.132146166835692 no 452 0.134640298505043 740 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2867 9039098 71.43 µM 1.10436539272624 0.132223854191459 no 453 0.134717333339996 688 6463460 SGTC_311 1315-0136 58 µM 1.09911645204437 0.133374940224217 no 454 0.135858637334582 723 6759207 SGTC_1950 st077106 7.18 µM 1.09728281244577 0.13377867498482 no 455 0.136258890956873 717 13831864 SGTC_844 0330-0132 15.3 µM 1.09671333323995 0.133904234953725 no 456 0.136383363026802 744 2828079 SGTC_3294 9122953 26.2835 µM 1.0952440983855 0.134228548866085 no 457 0.136704855409124 715 16459826 SGTC_1299 1079-1439 3.74 µM 1.09416124537979 0.134467919229261 no 458 0.136942132594328 667 323161 SGTC_1404 3909-7820 48.3 µM 1.09376433369578 0.134555732001008 no 459 0.137029175222111 692 23741373 SGTC_1288 0973-0013 65.5 µM 1.09208790552436 0.134927059286599 no 460 0.137397232458126 741 4315430 SGTC_1400 3771-8998 51.5 µM 1.08981124227061 0.135432462650516 no 461 0.137898150343542 671 670767 SGTC_2033 5192550 145 µM 1.08962461401859 0.135473950280301 no 462 0.137939267997532 697 182073 SGTC_712 r015-0009 80.6 µM 1.08747854557665 0.135951649137609 no 463 0.138412687572905 655 6813872 YLR060W FRS1 SGTC_332 4112-0506 40.9 µM 1.085880316246 0.136308151463054 no 464 0.138765973252524 714 2790355 SGTC_1711 st032263 62.8 µM 1.08376857809249 0.136780177608084 no 465 0.139233710226197 695 3958979 SGTC_1348 1493-0373 93.8 µM 1.08307927851075 0.136934494868189 no 466 0.13938661781576 726 3010129 SGTC_1498 4478-3555 97.6 µM 1.07830820220747 0.138005883373402 no 467 0.14044811894435 681 3437919 SGTC_2356 9061756 188.97 µM 1.07803457196547 0.138067502407794 no 468 0.140509164012322 710 20104043 SGTC_1987 st072290 61.9 µM 1.0770914692559 0.138280024298628 no 469 0.140719701902058 745 54697379 SGTC_1276 0871-0068 94.2 µM 1.07629464105356 0.138459757924191 no 470 0.140897752292685 714 3414906 SGTC_2702 st077768 96.8 µM 1.07501327044802 0.13874911929692 no 471 0.14118439351317 646 6484119 SGTC_1465 k213-0056 144 µM 1.07365268639529 0.139056819353752 no 472 0.141489187209269 714 24048857 YMR208W ERG12 SGTC_922 1866-0035 480 µM 1.07232257378449 0.139358076903611 no 473 0.141787585499399 833 3156169 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.07148103090485 0.13954890733602 no 474 0.141976597725775 812 368090 SGTC_1992 st073643 23.3 µM 1.07073234473503 0.13971883066032 no 475 0.142144897472905 707 3161292 SGTC_2797 7859098 81.82 µM 1.07065947763096 0.139735376233972 no 476 0.142161284727756 730 972681 SGTC_2226 7298446 200 µM 1.06914730947957 0.140079037459827 no 477 0.14250164837835 691 3283010 SGTC_1650 st011916 45.8 µM 1.06549548940159 0.140911330573478 no 478 0.143325882842304 742 242528 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.06287568347321 0.141510477896016 no 479 0.143919165857024 654 61125 An anti-inflammatory. SGTC_1947 st076332 61.6 µM 1.06207806013143 0.141693235942301 no 480 0.144100124660797 687 24208416 SGTC_659 k018-0002 107 µM 1.0586540823203 0.14247958170564 no 481 0.144878673466974 756 6797879 YHR007C ERG11 SGTC_885 0865-0106 16.8 µM 1.05861768723172 0.142487955971672 no 482 0.144886964216139 735 2793380 SGTC_701 4424-0219 185 µM 1.05815032207275 0.14259552314896 no 483 0.144993457720818 818 2911779 SGTC_1497 4476-2978 41.3 µM 1.05695531564297 0.142870811419299 no 484 0.145265990619637 803 1528379 SGTC_2116 5511452 16.8835 µM 1.05597352111244 0.143097251632099 no 485 0.145490156202628 764 870744 SGTC_986 1493-0483 84 µM 1.05527969993648 0.143257420065451 no 486 0.145648711268929 741 40079 SGTC_1880 MG-132 525 µM 1.05370067547415 0.14362238863222 no 487 0.146009989797044 696 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2098 5376439 882.5 nM 1.05077526026083 0.144300212875714 no 488 0.146680910422712 791 2844116 SGTC_1423 4048-0112 5.59 µM 1.0481920209291 0.144900544244617 no 489 0.147275073001962 765 X1423 SGTC_78 0336-0123 156.75 µM 1.04477919491316 0.145696242127189 no 490 0.14806251634275 698 6765896 SGTC_747 3448-8087 38.7 µM 1.04447337162315 0.14576768773528 no 491 0.148133216435361 769 5168703 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.04418215479821 0.145835742906586 no 492 0.148200560806374 792 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1940 st075990 51.1 µM 1.04333010839804 0.146034982336364 no 493 0.148397715570304 820 1084979 SGTC_1810 st050138 53 µM 1.0430367128726 0.146103631185975 no 494 0.148465644857358 743 3444541 SGTC_1581 himbacine 57.9 µM 1.04201673788448 0.146342454161702 no 495 0.148701959433815 762 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.03879356535906 0.147098868962454 no 496 0.14945037730444 717 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_150 3970-0969 77.2 µM 1.03804952216606 0.147273852923125 no 497 0.149623500058788 812 6615640 SGTC_2519 cryptotanshinone 88.04 µM 1.03585563338087 0.147790623253357 no 498 0.15013474924047 764 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1408 3909-7976 48.8 µM 1.03512568755222 0.147962830807963 no 499 0.150305108813453 832 24152374 SGTC_1756 st041558 35.5 µM 1.03511473444821 0.147965415867717 no 500 0.150307666101728 849 3955792 SGTC_1547 harmine 94.2 µM 1.03423240446389 0.148173755298851 no 501 0.150513764329572 837 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_974 1326-0144 138 µM 1.0337678870982 0.148283517905817 no 502 0.150622343790097 788 5411856 SGTC_2432 5630864 12.22 µM 1.03279378433702 0.148513869006935 no 503 0.150850206575437 747 5714970 SGTC_1708 st033234 31.827 µM 1.03001615233439 0.149172023280053 no 504 0.151501211644681 828 674664 SGTC_15 0266-0086 27.098 µM 1.03000124495222 0.14917556080101 no 505 0.151504710581109 874 1712902 YIL048W NEO1 SGTC_612 0302-0167 22.4 µM 1.02965851060898 0.149256907092348 no 506 0.151585169144877 860 235821 SGTC_2624 nerol 100 µM 1.02709447654732 0.149866407354484 no 507 0.152187989647701 765 637566 A natural product oil. SGTC_2163 5671233 125 µM 1.02493414552077 0.150381229540916 no 508 0.152697130924595 825 701023 SGTC_1944 st076371 56.9 µM 1.02448940409666 0.150487360661015 no 509 0.152802086524257 748 24208455 SGTC_1524 corynanthine 62.1 µM 1.02436244840379 0.150517665956636 no 510 0.152832055879814 756 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_585 0kpi-0023 191 µM 1.02407955728368 0.1505852088529 no 511 0.152898849610535 724 64601 SGTC_468 gf-109203x 121 µM 1.02146441946977 0.15121055318905 no 512 0.153517229073167 649 2396 A protein kinase C inhibitor. SGTC_1859 st055998 20 µM 1.01710580988189 0.152256638733041 no 513 0.154551548373753 813 676301 SGTC_2225 6654152 15.4 µM 1.01328456470357 0.15317769776365 no 514 0.155462129014396 716 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_719 2810-4230 27.3 µM 1.01311421918258 0.153218843020929 no 515 0.155502803614179 764 721079 SGTC_945 3381-0768 11.3 µM 1.01137637024089 0.153639021510183 no 516 0.155918163188232 836 1126236 YIL048W NEO1 SGTC_294 k038-0071 157 µM 1.00995340233185 0.153983635397192 no 517 0.156258807806487 788 24152826 SGTC_2043 5101342 149 µM 1.00860750840637 0.154310053831272 no 518 0.156581452484387 765 678451 SGTC_47 0149-0135 24.25 µM 1.00848405951345 0.154340016671619 no 519 0.156611068237382 773 5239155 SGTC_1847 st056231 15 µM 1.00845951604888 0.154345974185569 no 520 0.156616956726235 838 5393180 SGTC_561 1550-0330 72.9 µM 1.00778450320904 0.154509881816266 no 521 0.156778963506304 753 6812934 SGTC_3147 9097027 49.47 µM 1.00678702598873 0.154752301286494 no 522 0.157018565328971 839 25236841 SGTC_278 4092-0821 23.9 µM 1.00559388839779 0.155042602492907 no 523 0.15730548250728 813 877900 SGTC_69 0096-0274 206.684 µM 1.00114442739083 0.156128365786608 no 524 0.158378494462733 867 6741392 SGTC_2796 7949634 45.45 µM 0.998967627211012 0.156661372192182 no 525 0.158905186868581 750 2971588 SGTC_799 1310-0557 151 µM 0.997213999016687 0.157091631761723 no 526 0.159330323671049 800 5354492 SGTC_151 3013-0144 2.285 µM 0.996678261617066 0.157223231874401 no 527 0.159460352318122 811 906558 YHR107C CDC12 SGTC_1078 idebenone 36.1 µM 0.995675815243597 0.157469670415782 no 528 0.159703842296588 845 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_149 3970-0822 46.1 µM 0.995483053754371 0.157517087433038 no 529 0.159750691119283 919 3114250 YBL034C STU1 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.988695792498252 0.15919265339328 no 530 0.161406001008258 733 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_96 0929-0093 37.281 µM 0.986663732882894 0.159696568923261 no 531 0.161903757483708 786 6991579 SGTC_1372 2752-0194 270 µM 0.984649629116043 0.16019706054261 no 532 0.162398101423982 769 823334 SGTC_2865 9030313 51.95 µM 0.984433067864832 0.160250935583321 no 533 0.162451312898325 756 42562754 SGTC_2487 5918373 44.05 µM 0.983889447332966 0.160386226989771 no 534 0.162584936409527 874 2876279 SGTC_1587 estradiol valerate 56.1 µM 0.983290783774174 0.160535303341289 no 535 0.162732172370634 834 13791 A steroid. SGTC_1640 st009078 66.4 µM 0.983046350554207 0.160596196954803 no 536 0.162792313466157 758 690618 SGTC_1089 terbinafine 2.25 µM 0.981783815139528 0.160910962077394 no 537 0.16310318165087 822 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_811 0416-0114 265 µM 0.979792016335662 0.161408359517118 no 538 0.163594396901301 799 6612453 SGTC_2711 st079103 59.1 µM 0.979045662214256 0.161594999082138 no 539 0.163778709093325 807 54693780 SGTC_33 0986-0033 35.816 µM 0.977604469162401 0.161955793851809 no 540 0.164134993053479 798 2848082 SGTC_333 3486-0131 40.1 µM 0.977358527886719 0.162017416276094 no 541 0.164195843503647 870 6744690 SGTC_408 cantharidin 100 µM 0.976976919112344 0.16211306143385 no 542 0.164290289577027 833 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3030 9087619 49.47 µM 0.976824587627598 0.162151251558516 no 543 0.16432800061714 829 25236973 SGTC_3221 9128209 49.47 µM 0.97633008505564 0.162275265744113 no 544 0.164450457889438 787 16460723 SGTC_1790 st045711 43.5 µM 0.975790127235551 0.16241074995931 no 545 0.164584239115763 811 585119 SGTC_517 1365-0151 113 µM 0.97386017019023 0.162895609280982 no 546 0.165062986199535 820 768657 SGTC_1179 1021-1431 9.29 µM 0.973579896281395 0.162966100130035 no 547 0.165132586124267 860 2840958 SGTC_874 0599-0792 117 µM 0.973539835688417 0.162976177269075 no 548 0.165142535852055 914 765305 SGTC_3071 9117417 49.47 µM 0.97194895413369 0.163376686888056 no 549 0.165537971953715 727 45595590 YGL055W OLE1 SGTC_2564 betulinic acid 100 µM 0.971647876064835 0.163452556162404 no 550 0.165612878027779 893 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1796 st049173 110.4 µM 0.970855166702407 0.16365242202658 no 551 0.165810203272739 791 94134 SGTC_2809 7964133 12.99 µM 0.968363798934988 0.164281603231877 no 552 0.166431356205133 822 1253665 SGTC_2308 7584454 197.62 µM 0.96831985563299 0.164292714929093 no 553 0.166442325705541 871 893577 SGTC_1053 3366-3204 134 µM 0.96706429930763 0.164610406313052 no 554 0.166755945537049 819 3632071 YPR165W RHO1 SGTC_896 0964-0007 44.5 µM 0.967052196548243 0.164613470590473 no 555 0.166758970485693 860 6756758 SGTC_3004 9076122 71.4286 µM 0.965736434780671 0.164946826552154 no 556 0.167088041489056 843 44782551 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.964218141794866 0.165332037860324 no 557 0.167468285364304 894 66535 A nucleotide analog. SGTC_1571 st070080 73.4 µM 0.96295723803551 0.165652388150697 no 558 0.167784491666665 841 4315245 SGTC_3182 9108849 49.47 µM 0.962330678756915 0.165811723507629 no 559 0.16794176152281 865 17133045 SGTC_3341 9147222 25.867 µM 0.960099956354702 0.166379804923757 no 560 0.168502455222662 795 1939759 SGTC_2831 7999036 19.48 µM 0.955891935707849 0.167454847170158 no 561 0.169563416828071 886 2988270 SGTC_1914 st062367 72.6 µM 0.955191870792536 0.1676341292134 no 562 0.169740338016003 803 978205 SGTC_702 1488-0190 94 µM 0.954959714926725 0.167693610097645 no 563 0.169799034836673 855 949357 SGTC_2602 kawain 100 µM 0.954291973436806 0.167864768564325 no 564 0.169967934920725 910 5369129 SGTC_841 0251-0215 91.2 µM 0.952763688652309 0.16825692841408 no 565 0.170354907998958 894 3888614 SGTC_82 0054-0107 293.755 µM 0.952235984911596 0.168392474642669 no 566 0.170488657482618 860 3104697 SGTC_1459 k035-0031 35.7 µM 0.9518028336934 0.168503786527577 no 567 0.170598492334264 760 3877128 YMR208W ERG12 SGTC_476 mead acid 10 µM 0.950915332348126 0.168732005759322 no 568 0.170823678947004 814 5312531 An omega 9 fatty acid. SGTC_1264 0783-0040 158 µM 0.950659628927347 0.168797796236374 no 569 0.170888594115027 822 2855798 SGTC_1852 st056254 31.4 µM 0.949652009537852 0.169057209202013 no 570 0.171144551050575 833 442583 SGTC_2582 agaric acid 100 µM 0.94703387798517 0.169732446914564 no 571 0.171810758070569 988 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_680 0417-1641 114 µM 0.945382626529723 0.17015920652361 no 572 0.172231784312383 817 2835990 SGTC_676 falcarinol 140 µM 0.942047112788844 0.171023352488815 no 573 0.173084259863921 906 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1747 st037496 66.6 µM 0.941142415779708 0.171258219372911 no 574 0.173315940812601 882 723305 SGTC_1855 st056195 39.6 µM 0.935612935219743 0.172698197701905 no 575 0.174736256076096 836 4028379 SGTC_3298 9116858 71.43 µM 0.935590829011322 0.172703970011537 no 576 0.174741949116909 884 2506942 SGTC_1766 st045414 44.774 µM 0.931220341322877 0.173847594598037 no 577 0.175869798899988 928 253960 SGTC_869 0564-0080 44.1 µM 0.93043483807422 0.174053646520314 no 578 0.17607299388919 853 6843321 SGTC_862 0452-0056 10.2 µM 0.926660895884232 0.175045784478662 no 579 0.177051313309384 870 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_3321 9137793 26.8275 µM 0.925048630097844 0.175470727354866 no 580 0.17747030610252 881 4904192 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.922602649747296 0.176116658690852 no 581 0.178107157158198 866 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2117 5521686 200 µM 0.91871128244372 0.177147383654577 no 582 0.179123303457156 857 803312 SGTC_2232 chlorophetanol 41.5365 µM 0.918015235463052 0.177332149871784 no 583 0.179305444816438 1008 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_666 0272-0154 136 µM 0.916386588913229 0.177764950633409 no 584 0.17973208342459 890 6870312 SGTC_624 k048-0052 28 µM 0.916339842406885 0.177777383001198 no 585 0.179744338500579 849 6835531 SGTC_1644 st010134 20.9 µM 0.916031868394083 0.177859303285457 no 586 0.179825090167973 875 3818134 SGTC_3108 9121785 49.47 µM 0.915171165488947 0.17808837424115 no 587 0.180050889745309 887 17140271 SGTC_1575 cyproterone acetate 48 µM 0.913755851841353 0.178465455723382 no 588 0.18042257453048 869 9880 An androgen receptor antagonist and liver toxin. SGTC_705 1124-0212 310 µM 0.911748562626916 0.179001118835595 no 589 0.180950546705846 907 9554485 SGTC_2079 5212404 121 µM 0.911136361975128 0.179164691183695 no 590 0.181111764768385 936 758462 SGTC_2461 5755302 26.15 µM 0.910773356965929 0.179261725965698 no 591 0.18120740166768 909 2788904 SGTC_89 0302-0250 142.109 µM 0.90988315487913 0.179499825544643 no 592 0.181442067190972 966 4203518 YLR208W SEC13 SGTC_1331 1472-0049 76.2 µM 0.9083453459609 0.179911606566528 no 593 0.181847895826883 844 24051409 SGTC_2215 7188065 200 µM 0.90788312661387 0.180035491487422 no 594 0.181969986658321 888 940217 SGTC_2076 5212012 200 µM 0.903400010773501 0.181239842505172 no 595 0.183156817142937 821 604802 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.903322668147486 0.181260664122144 no 596 0.183177334595155 925 6728940 SGTC_341 1486-1430 230 µM 0.903108339559122 0.181318371926835 no 597 0.183234199174507 886 2054753 YPL210C SRP72 SGTC_3033 9090887 49.47 µM 0.901871554460466 0.181651600040497 no 598 0.183562551774906 929 19325384 SGTC_500 h-89 112 µM 0.90142592967634 0.181771758975983 no 599 0.183680949977904 954 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_855 0428-0020 25 µM 0.901103273679447 0.181858791450538 no 600 0.183766706252409 820 6812414 SGTC_688 0527-0193 473 µM 0.897650254189303 0.182791832249017 no 601 0.184686019050079 882 4007154 SGTC_1487 3970-0795 2.82 µM 0.896109558441922 0.183209106213727 no 602 0.185097126264029 946 3765103 SGTC_1289 0976-0073 69.1 µM 0.895788824812108 0.183296046681977 no 603 0.185182779752553 943 3391136 SGTC_3144 9087057 49.47 µM 0.89576388817976 0.183302807270651 no 604 0.185189440233708 893 17249618 SGTC_1690 st023502 41.2 µM 0.895690611166243 0.183322674355247 no 605 0.185209013110662 899 24207482 SGTC_104 0074-0074 590.992 µM 0.88973390041182 0.184942164396984 no 606 0.186804393222774 790 3943124 SGTC_1578 josamycin 24.2 µM 0.887111833455262 0.185657852209634 no 607 0.187509346841518 849 5282165 A P450 substrate. SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.886335256006959 0.185870146826393 no 608 0.1877184480774 959 688798 SGTC_741 4582-0002 126 µM 0.885993977021818 0.185963490581563 no 609 0.187810386394235 903 2912688 SGTC_2423 st077119 87.2 µM 0.88320086635669 0.186728530657125 no 610 0.188563876799437 913 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1076 itraconazole 331 nM 0.882148269494722 0.187017344331428 no 611 0.18884831609313 994 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2761 levamisole 97.89 µM 0.881748072328059 0.187127223715656 no 612 0.188956529202693 913 26879 An alkaline phosphatase inhibitor. SGTC_1931 st074438 57.1 µM 0.880949448231103 0.187346615757132 no 613 0.189172590901693 924 2787313 SGTC_781 4335-2806 94.4 µM 0.880777967491208 0.187393744393232 no 614 0.189219003548709 1028 845254 SGTC_1875 nocodazole 6 µM 0.879432398629257 0.187763805984171 no 615 0.18958343593295 943 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_651 3253-0966 34.4 µM 0.877813268464513 0.188209700948123 no 616 0.190022531353682 947 781462 SGTC_2124 5246320 200 µM 0.874858311873188 0.189025154043236 no 617 0.190825502205061 911 579342 SGTC_2676 harmalol 100 µM 0.874667063542894 0.189078006021579 no 618 0.190877543072839 952 5459187 A monoamine oxidase inhibitor SGTC_263 alizarin 107.927 µM 0.87326299198883 0.189466303515791 no 619 0.191259873627297 994 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2021 4019055 173 µM 0.871812440740996 0.189867969965337 no 620 0.191655353283107 1015 44827708 YER133W GLC7 SGTC_1088 bifonazole 369 nM 0.871804588339527 0.189870145766798 no 621 0.191657495531286 923 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_598 3937-0236 20.2 µM 0.869471160148771 0.190517388308289 no 622 0.192294737888365 1002 1379313 SGTC_2586 curcumin 80 µM 0.869214517843562 0.190588657933144 no 623 0.192364904058444 1006 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2203 7227154 166.4 µM 0.865807338816589 0.191536382605165 no 624 0.193297911992682 987 896304 SGTC_1556 plumbagin 1.48 µM 0.865510126265159 0.191619190513905 no 625 0.193379430207459 907 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_75 0159-0059 199.013 µM 0.862329168690623 0.19250682601523 no 626 0.194253202962106 936 5377270 SGTC_671 0560-0003 407 µM 0.860644970127574 0.192977812030462 no 627 0.194716805019974 926 3238678 SGTC_169 k015-0017 16.025 µM 0.860495651422018 0.193019602929752 no 628 0.194757939792955 906 1840002 SGTC_1412 3909-8563 178 µM 0.859895037086439 0.193187756994374 no 629 0.194923452251761 1047 23767530 SGTC_1174 0739-0097 51.1 µM 0.859812520752934 0.193210866086206 no 630 0.194946198118834 948 728447 SGTC_1704 st028805 70.8 µM 0.859117606733672 0.193405546994103 no 631 0.195137817207498 946 2876101 SGTC_1814 st052110 31.539 µM 0.858748023996679 0.193509134728815 no 632 0.195239774426735 966 674163 SGTC_1624 st003710 6.25 µM 0.858572121676739 0.193558449032065 no 633 0.195288312171932 1015 24207033 SGTC_1620 st003704 16.5 µM 0.858560849693971 0.19356160939937 no 634 0.195291422765318 977 2834414 SGTC_2620 irigenin 100 µM 0.854841840194742 0.194606039307466 no 635 0.19631935586361 980 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_195 4234-0266 16.654 µM 0.853632804521653 0.194946316727948 no 636 0.19665423815642 985 2303354 SGTC_2404 5161160 200 µM 0.853186557192533 0.195072002299914 no 637 0.196777928445283 979 2831543 SGTC_2262 9014885 67.46 µM 0.853056454718543 0.195108654937069 no 638 0.196813998958242 932 6457424 SGTC_3281 9140613 49.47 µM 0.852373263743875 0.195301193077626 no 639 0.197003477271852 908 16013766 SGTC_2930 9013230 14.89 µM 0.851670127835939 0.195499472633691 no 640 0.197198602427181 995 2995857 SGTC_2373 9071805 200 µM 0.851110434223084 0.195657389789131 no 641 0.197354004887813 996 10149009 SGTC_1434 4073-0095 163 µM 0.850794511034996 0.195746561475212 no 642 0.197441755647409 1016 24133745 SGTC_2830 7992007 71.43 µM 0.848745600940006 0.196325480248332 no 643 0.198011432978042 928 1952075 SGTC_2549 cedrol 20.94 µM 0.847585808084757 0.196653638823828 no 644 0.198334340384562 954 6708665 A sedative which affects the nervous system. SGTC_2063 5246145 200 µM 0.847289024911698 0.196737665752146 no 645 0.198417021249287 1006 711240 SGTC_2127 5253358 187.912 µM 0.846738942166082 0.196893465777291 no 646 0.198570323862566 889 20612 SGTC_3148 9097893 49.47 µM 0.845965659723681 0.19711260895844 no 647 0.198785950788078 956 17174100 SGTC_76 0433-0009 400.328 µM 0.845062473694049 0.197368752753378 no 648 0.199037979491549 873 2841569 SGTC_1205 4161-2785 76 µM 0.841845018298455 0.198282858573333 no 649 0.199937354698558 860 3498106 SGTC_3047 9092122 49.47 µM 0.840231527643397 0.198742225099132 no 650 0.20038929223045 964 17173831 SGTC_2827 7993847 71.43 µM 0.840228774469541 0.198743009485499 no 651 0.200390063916478 903 2985692 SGTC_1030 k029-0042 36.7 µM 0.83979661782657 0.198866155173068 no 652 0.200511215064306 1003 6080581 SGTC_2353 9059630 146.67 µM 0.839380023755188 0.198984909738962 no 653 0.200628045017748 1014 4779114 SGTC_505 gw-5074 63.9 µM 0.838981776359335 0.199098474333518 no 654 0.200739768016582 995 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1539 benzyladenosine 56 µM 0.838228889042304 0.199313275033818 no 655 0.200951082523749 996 92208 A nucleotide analog. SGTC_539 4859-0462 2.54 µM 0.837683205516674 0.199469047145187 no 656 0.201104324080521 1022 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2910 7948405 25.97 µM 0.836171832089904 0.199900869794553 no 657 0.20152912119319 962 2971328 SGTC_2229 7354935 190 µM 0.834700872697208 0.200321684907196 no 658 0.201943075089104 964 318112 SGTC_1308 1187-1617 41.4 µM 0.834504878611119 0.200377795456467 no 659 0.201998269680805 1015 2882570 SGTC_1652 st011932 78 µM 0.834428991926706 0.200399523359225 no 660 0.202019642824508 975 1551076 SGTC_1840 st055363 71 µM 0.830668741534598 0.201477931269638 no 661 0.203080394757188 924 676033 SGTC_939 1165-0479 45.3 µM 0.82897263369145 0.20196549649979 no 662 0.203559946425829 993 1377347 SGTC_2927 9011802 47.9 µM 0.827298174643877 0.202447530655096 no 663 0.204034039063961 969 43912568 SGTC_236 1509-0011 5.31 µM 0.8270497136991 0.202519114802486 no 664 0.204104442267598 1138 3107280 SGTC_1474 0330-0125 5.35 µM 0.826132553312993 0.202783489114411 no 665 0.204364451558527 1040 X1474 SGTC_1219 1469-0211 33.1 µM 0.82612818698481 0.202784748214945 no 666 0.204365689856948 997 6822282 SGTC_2283 7944793 200 µM 0.825496130424728 0.202967061100816 no 667 0.204544989337714 1044 2970533 SGTC_2815 7968870 71.43 µM 0.824885569397389 0.203143266648478 no 668 0.204718279901295 1017 2977326 YHR190W ERG9 SGTC_1265 0819-1001 68.8 µM 0.824071780299752 0.203378264951658 no 669 0.204949386750428 985 3106768 SGTC_2517 totarol 10 µM 0.818657434170721 0.204945893684253 no 670 0.206490944270096 989 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2130 NSC 7 2.4545 µM 0.818337021863614 0.205038888025443 no 671 0.206582385935774 1037 21448 SGTC_1267 0828-0272 9.49 µM 0.817345127113623 0.205326927932178 no 672 0.206865612298021 1035 745334 SGTC_1381 2324-0066 62.1 µM 0.817253760417623 0.205353472322074 no 673 0.206891712767764 957 10885928 SGTC_27 0485-0001 32.618 µM 0.817073863233714 0.20540574306724 no 674 0.206943109192165 959 2054479 SGTC_1165 k072-0275 30.3 µM 0.815628262131061 0.205826062261843 no 675 0.20735639005248 1033 6153523 YGL055W OLE1 SGTC_1898 st060199 18.6 µM 0.814352444664698 0.206197439197054 no 676 0.207721536758886 1042 688866 SGTC_1351 1496-0003 46.5 µM 0.81238748697453 0.206770193940465 no 677 0.208284661998602 1047 3891978 SGTC_2862 9027634 71.43 µM 0.812221258678247 0.206818690087458 no 678 0.208332341634754 958 5012562 SGTC_1797 st048695 56.8 µM 0.809534927589328 0.207603344913897 no 679 0.209103760388677 1028 592262 YIL048W NEO1 SGTC_1989 st071868 50.2 µM 0.809091482413988 0.207733040482307 no 680 0.209231263620002 1058 16414057 SGTC_2520 obtusaquinone 4.71 µM 0.808072414243133 0.208031271329236 no 681 0.209524448382491 1050 5967872 SGTC_2354 9060492 162 µM 0.806965633770498 0.208355457365031 no 682 0.209843141481188 1064 6471895 SGTC_280 3448-3607 3.04 µM 0.806484346387081 0.208496523719934 no 683 0.209981815143686 1032 626179 SGTC_48 0382-0018 55 µM 0.804070367758928 0.20920491515035 no 684 0.210678168424451 1060 762596 SGTC_1170 0310-0127 64.8 µM 0.802209655497536 0.209751914139681 no 685 0.211215846014804 1036 774975 SGTC_1860 st056228 74.6 µM 0.799808698393613 0.210458971589867 no 686 0.211910821283331 1034 688679 SGTC_1320 1313-0481 95.3 µM 0.795722069026087 0.211665654249619 no 687 0.213096798303938 1086 6813365 YLR208W SEC13 SGTC_1932 st074806 40.9 µM 0.794886695776189 0.211912817303739 no 688 0.213339706980628 1173 17251235 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.792941680484557 0.212488945442941 no 689 0.213905900913731 1040 364106 SGTC_1886 st057356 49.9 µM 0.792443390351928 0.21263668982438 no 690 0.214051093818812 991 24207747 SGTC_567 1080-0542 68.4 µM 0.792095994677523 0.212739729069491 no 691 0.214152352681459 1001 5950415 SGTC_1645 Cervolide 78 µM 0.791851883047145 0.212812151201124 no 692 0.214223522990826 995 23173 A fragrance. SGTC_339 3091-4833 71.4 µM 0.791343740313133 0.212962951249619 no 693 0.214371715222795 1047 3240077 SGTC_1072 oxiconazole 14.9 nM 0.789249913255524 0.213584987706018 no 694 0.21498297721487 1054 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_589 1227-0070 34.1 µM 0.788803015302671 0.213717889600727 no 695 0.215113573445978 1042 2841384 SGTC_3137 9097352 49.47 µM 0.78857933085032 0.213784428660592 no 696 0.215178957666087 1130 44120435 SGTC_2526 patulin 37.61 µM 0.788474558387464 0.21381559930781 no 697 0.215209587211325 1070 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_3195 9113082 49.47 µM 0.787989639989344 0.213959900884426 no 698 0.215351382894059 1030 17018038 SGTC_3044 9093193 49.47 µM 0.784820824367251 0.214904268892934 no 699 0.216279314369388 1075 25236277 SGTC_1909 st060837 51.5 µM 0.783773714359341 0.215216859206835 no 700 0.21658645005445 1005 678937 SGTC_2502 avocadyne acetate 18.59 µM 0.782100137095672 0.215717014300725 no 701 0.217077863094023 1114 3952079 SGTC_2972 9093619 59.92 µM 0.781938093356674 0.215765477458067 no 702 0.217125478235584 1023 25236256 SGTC_4 0960-0234 25.671 µM 0.781406717530523 0.215924442713599 no 703 0.217281660725221 1037 6821112 SGTC_1653 st012112 65 µM 0.780969416805253 0.216055315551189 no 704 0.217410241227168 1043 720429 SGTC_1979 st071809 45.3 µM 0.780322876044901 0.216248892698299 no 705 0.217600425507952 1082 4976333 SGTC_20 0481-0013 4.944 µM 0.778200955322103 0.216884910235666 no 706 0.218225276860365 1079 182045 SGTC_193 1273-0060 1.558 µM 0.778097255573785 0.216916020547442 no 707 0.218255840258073 961 2847393 YHR072W ERG7 SGTC_3157 9099274 49.47 µM 0.775190003059798 0.217789256484142 no 708 0.219113697262824 1068 17217662 SGTC_2348 9022543 33.42 µM 0.774056034127863 0.218130409633763 no 709 0.219448827800935 1056 3162678 YDL140C RPO21 SGTC_1100 amiodarone 5.07 µM 0.773844632016464 0.218194043742245 no 710 0.21951133763992 1106 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2600 tangeritin 87.95 µM 0.770503030114645 0.219201318718085 no 711 0.220500779145901 1064 68077 A bioactive flavone. SGTC_1216 1165-0504 9.65 µM 0.770083742720164 0.219327894988171 no 712 0.220625109491881 1082 6304004 SGTC_2141 5621638 7.665 µM 0.769528901827792 0.219495457278691 no 713 0.220789696929867 1079 2856238 SGTC_2663 amphotericin b 100 µM 0.768464040857295 0.219817251863371 no 714 0.221105773086485 1084 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2896 9052656 71.43 µM 0.768362001367766 0.219848101795088 no 715 0.221136074430599 1086 6469436 SGTC_1531 st059297 52.4 µM 0.766347627418245 0.220457622584484 no 716 0.221734743170199 1091 7566702 SGTC_2106 5357045 167.29 µM 0.764769883962304 0.220935700817441 no 717 0.222204291969629 1089 668842 SGTC_2023 5144124 124 µM 0.764237114151595 0.221097271425905 no 718 0.222362976495603 1062 2830192 SGTC_1742 st038235 28.8875 µM 0.761981808981737 0.2217819756924 no 719 0.223035430642572 1052 564103 YBR002C RER2 SGTC_139 0099-0334 718.624 µM 0.76170758611312 0.221865311494468 no 720 0.223117273330007 1167 97690 SGTC_681 1642-0006 26.6 µM 0.76109314814985 0.222052102925591 no 721 0.223300716362516 1111 4446530 SGTC_909 3448-9333 149 µM 0.759989648183801 0.222387796328576 no 722 0.223630386321981 1033 3344074 SGTC_1744 st037937 38.9 µM 0.759466413959757 0.222547069425729 no 723 0.223786798913344 1116 1016152 SGTC_1795 st049545 62.3 µM 0.758530011267362 0.222832273771926 no 724 0.224066876852568 1088 5291882 SGTC_2928 9011484 9.79 µM 0.756993196067087 0.223300799496625 no 725 0.224526969374164 1071 2994751 SGTC_2271 7849410 118.62 µM 0.756766282125365 0.223370025759257 no 726 0.224594948373922 1110 972430 SGTC_2492 derrusnin 100 µM 0.753711814559794 0.224303061836032 no 727 0.225511143043234 1030 1715307 Part of coumarin class of compounds. SGTC_3302 9125395 16.351 µM 0.75336356608884 0.224409580244288 no 728 0.225615735157696 1067 17599668 SGTC_1676 st018489 23.4 µM 0.753352856894946 0.224412856309554 no 729 0.225618951966406 1070 3696235 SGTC_1758 st042942 75.2445 µM 0.753108857865764 0.224487505765924 no 730 0.225692250994535 1101 669317 SGTC_147 4466-0538 29.23 µM 0.749579220177418 0.225568943804638 no 731 0.226754084924789 1232 6742687 YHR072W ERG7 SGTC_3293 9120939 62.045 µM 0.749376757886259 0.22563106506656 no 732 0.226815077765429 1089 934087 SGTC_1359 1582-0056 520 nM 0.748639967941738 0.225857215137652 no 733 0.227037117761995 1131 3661189 SGTC_2343 7990716 14.84 µM 0.747984579707797 0.226058487473358 no 734 0.22723472938668 1098 6456862 SGTC_2086 5274770 176.623 µM 0.747984075470457 0.226058642365673 no 735 0.227234881460834 1094 689278 SGTC_395 anisomycin 6.25 µM 0.747720199585239 0.226139708349891 no 736 0.227314472293329 1037 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2126 5251174 33.877 µM 0.745826008230175 0.226722109710788 no 737 0.227886263366059 1171 790722 SGTC_523 1934-0222 13.7 µM 0.744207502789022 0.227220416612443 no 738 0.22837547484607 1136 1361595 SGTC_358 0075-0058 9.45 µM 0.74362954976988 0.22739850675388 no 739 0.228550310542842 1138 1069125 SGTC_79 0052-0007 94.094 µM 0.743227538235904 0.227522428733476 no 740 0.228671966768346 1123 2801472 SGTC_785 1270-0111 65.3 µM 0.742719293950434 0.227679151887177 no 741 0.228825823048723 1138 6741994 SGTC_1360 1598-0022 39.8 µM 0.74225260107086 0.227823115678894 no 742 0.228967152000919 1151 761525 SGTC_1074 carmofur 3.8 µM 0.742171412311203 0.227848165734175 no 743 0.228991743453954 1179 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2476 5806916 10.51 µM 0.741779931732713 0.227968975267059 no 744 0.229110340718439 1060 2870194 SGTC_2286 7945697 125 µM 0.741588980278989 0.228027915287489 no 745 0.229168201093209 1122 1245733 SGTC_1963 st076565 50.3 µM 0.740271736532277 0.228434735671849 no 746 0.229567563502273 1140 4914280 SGTC_363 0455-0021 3.06 µM 0.739812414353381 0.228576689554076 no 747 0.229706912589647 1129 4597466 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.739387404654957 0.228708083258079 no 748 0.229835894148408 1123 616764 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.737663719882559 0.229241402878412 no 749 0.230359411929396 1073 688803 SGTC_2810 7959871 45.46 µM 0.736963942755562 0.229458117467589 no 750 0.230572138473182 1145 2974535 SGTC_3131 9127911 49.47 µM 0.736667532962974 0.229549947479435 no 751 0.230662277721722 1141 45595681 SGTC_1038 k292-0204 154 µM 0.736228880423 0.229685883153927 no 752 0.230795709603871 1114 4454212 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.735948408910798 0.229772823143662 no 753 0.230881047649621 1134 97141 SGTC_356 1634-0012 32.5 µM 0.735575269639439 0.229888516657906 no 754 0.230994608685529 1153 735457 SGTC_2357 9067248 200 µM 0.735190200421879 0.230007943288957 no 755 0.231111833160302 1116 9150235 SGTC_929 2805-0021 398 µM 0.7341260670671 0.230338157586807 no 756 0.231435953917523 1112 3098024 SGTC_2210 7115885 190.385 µM 0.73354161340097 0.230519633812344 no 757 0.231614078447895 1149 2927039 SGTC_1323 1348-1351 11.2 µM 0.733215005290281 0.23062108230551 no 758 0.231713652400103 1079 6989654 SGTC_971 1315-0384 26.7 µM 0.732837127694073 0.230738486852336 no 759 0.231828886784637 1139 6769120 SGTC_1137 ixabepilone 100 µM 0.732460831329834 0.230855433288246 no 760 0.231943670685327 1135 154225 A novel microtubule stabilizer. SGTC_1296 1068-0102 11.9 µM 0.73230615793318 0.230903512715857 no 761 0.231990860800681 1102 767053 SGTC_821 1114-0266 29.2 µM 0.730148489358505 0.231574795558682 no 762 0.232649712342583 1126 3123235 SGTC_389 tpck 16.7 µM 0.730000258107269 0.231620952408093 no 763 0.232695013416249 1117 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1651 st011928 86.1 µM 0.728980155867036 0.231938735009415 no 764 0.233006900621946 1125 720198 SGTC_682 0kpi-0099 17 µM 0.728506656960514 0.232086322016489 no 765 0.233151747560613 1172 1714895 YML126C ERG13 SGTC_59 0330-0160 1.33 µM 0.727188525259756 0.23249745162974 no 766 0.23355523728032 1167 4293482 SGTC_1751 st044839 27.194 µM 0.726779731804856 0.232625037881201 no 767 0.233680450561179 1163 5291326 SGTC_1347 1493-0251 600 nM 0.726440246901676 0.232731022201588 no 768 0.233784462938464 1152 3986378 SGTC_451 chloral hydrate 100 µM 0.726208663096573 0.232803336104232 no 769 0.233855430981375 1210 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_478 N-arachidonylglycine 10 µM 0.726132891778205 0.232826999017238 no 770 0.233878653427192 1073 5283389 SGTC_1755 st041960 45.185 µM 0.725613885455265 0.232989117395069 no 771 0.234037753189181 1145 2257073 SGTC_1610 st001799 48.1 µM 0.724014862199318 0.233488987021824 no 772 0.234528305408508 1057 621897 SGTC_2448 5185112 27.17 µM 0.72380771837836 0.233553785610483 no 773 0.234591895077956 1130 5718189 SGTC_249 wiskostatin 11.211 µM 0.723278531289492 0.233719370827931 no 774 0.23475438990521 1171 2775510 A n-wasp and actin depolymerizer. SGTC_3228 9131799 49.47 µM 0.721562485332972 0.234256777387375 no 775 0.23528175536147 1101 17015818 SGTC_2156 5649887 115 µM 0.721266280104323 0.234349607851366 no 776 0.235372849609514 1214 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2846 9008642 19.48 µM 0.720841724970771 0.234482698560526 no 777 0.2355034502214 1147 2992898 SGTC_407 eburnamonine 100 µM 0.720364535356785 0.234632339171607 no 778 0.235650289838663 1074 3195 SGTC_475 α-linolenic acid 10 µM 0.720263188595682 0.234664127028449 no 779 0.235681482515533 1245 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_106 0092-0003 11.579 µM 0.71981689827839 0.234804136276811 no 780 0.235818869590486 1105 1072148 SGTC_556 4058-0063 51.5 µM 0.719529286951085 0.234894389552374 no 781 0.235907431938004 1203 6615692 SGTC_1451 4152-0210 104 µM 0.719262887462271 0.234978003591346 no 782 0.235989479009076 1159 659563 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.719246071147648 0.234983282231255 no 783 0.235994658710878 1146 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1050 3232-1156 69.3 µM 0.717990113151539 0.235377712481426 no 784 0.236381691477496 1115 700529 SGTC_1627 st003713 25.6 µM 0.717856547650184 0.235419679856642 no 785 0.2364228712228 1202 16195070 YER133W GLC7 SGTC_2016 5121758 140 µM 0.717478563553353 0.235538467934517 no 786 0.236539429365396 1187 2795203 SGTC_3083 9117465 49.47 µM 0.716904345231844 0.235718989291997 no 787 0.236716560325053 1160 16420915 SGTC_1085 doxorubicin 7.67 µM 0.716894533553088 0.235722074526514 no 788 0.236719587598765 1194 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3080 9117754 49.47 µM 0.716812768154176 0.235747786123308 no 789 0.236744816142622 1199 9550191 SGTC_2984 9022109 38.96 µM 0.714434194521159 0.236496418638216 no 790 0.237479366931965 1163 6459207 SGTC_247 mechlorethamine 29.705 µM 0.712998664807473 0.23694886973469 no 791 0.237923291675809 1107 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_3112 9123419 49.47 µM 0.711705755522593 0.23735677655765 no 792 0.238323501437746 1229 17015854 SGTC_1140 3229-1848 2.98 µM 0.710340355980765 0.237787972005282 no 793 0.238746549969569 1179 2849525 SGTC_107 0358-0022 2.6945 µM 0.709070883410946 0.238189258674308 no 794 0.239140245243638 1120 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2648 atorvastatin 78.68 µM 0.708506210547914 0.238367873764608 no 795 0.239315478401535 1184 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_128 0906-2981 13.371 µM 0.706577359559543 0.238978553148625 no 796 0.239914581357077 1136 6740226 SGTC_1278 0874-0585 172 µM 0.706386164093312 0.239039132708383 no 797 0.239974011378764 1195 766306 SGTC_2778 tioconazole 65.09 nM 0.704721889244546 0.239566806308394 no 798 0.240491663247293 1158 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_749 1000-0129 128 µM 0.704262912000285 0.239712441036951 no 799 0.240634529275174 1230 708470 SGTC_2259 7964009 200 µM 0.703984960026736 0.239800659436571 no 800 0.240721069951356 1191 313134 SGTC_3315 9136395 68.55 µM 0.703769470310522 0.239869065302191 no 801 0.240788174584278 1233 16876844 SGTC_823 0417-1665 178 µM 0.703429369477783 0.239977049842013 no 802 0.240894104481996 1203 3429856 SGTC_925 2064-1272 59.6 µM 0.703408355893972 0.239983722680348 no 803 0.24090065033353 1155 6815817 SGTC_2940 9060638 45.86 µM 0.702298981480246 0.240336146824628 no 804 0.241246364161225 1168 4027022 SGTC_3342 9147791 14.508 µM 0.702157827297934 0.240381008652262 no 805 0.241290371300849 1154 1838168 SGTC_441 propafenone 146 µM 0.701371786801007 0.240630912594628 no 806 0.241535512126854 1172 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1872 amphotericin b 148 nM 0.699608069544013 0.241192161250558 no 807 0.242086050835771 1202 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_376 3970-0862 59.1 µM 0.698308730393971 0.24160609063862 no 808 0.242492070290477 1174 3135186 SGTC_827 3253-0474 693 µM 0.696429336577357 0.242205489330862 no 809 0.243079998103046 1197 5402065 SGTC_2552 juarezic acid 87.02 µM 0.695970769461554 0.242351863266002 no 810 0.243223567836934 1272 1549512 SGTC_111 0083-0039 52.457 µM 0.694746811949287 0.242742783262448 no 811 0.243606992923735 1123 759313 SGTC_2297 7971671 152.32 µM 0.694119941635738 0.242943131572213 no 812 0.243803496824771 1215 909016 SGTC_81 0411-0046 9.971 µM 0.693971280075233 0.242990657058805 no 813 0.24385011004178 1100 12925265 SGTC_384 k007-0144 5.16 µM 0.693733730754915 0.243066609434355 no 814 0.243924604227801 1185 6824886 SGTC_2362 9071156 126 µM 0.691470580398915 0.243790856889875 no 815 0.244634931327139 1209 653133 SGTC_1990 st072050 59.8 µM 0.689944416298023 0.244279912745011 no 816 0.245114571284972 1219 17233948 SGTC_357 1325-0123 420 µM 0.689806790899902 0.244324040474652 no 817 0.2451578487811 1187 1098503 SGTC_1027 k015-0025 8.67 µM 0.689427373459196 0.244445717811568 no 818 0.245277181151598 1196 3598955 SGTC_604 1000-0114 314 µM 0.688326772590212 0.244798859827748 no 819 0.245623512919909 1236 1572745 SGTC_1986 st071812 45 µM 0.688126452694351 0.244863164583323 no 820 0.245686576857793 1159 11838594 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.685766356073672 0.245621464014918 no 821 0.246430227606716 1267 94937 An inhibitor of serotonin biosynthesis. SGTC_2482 5981709 142.65 µM 0.683477223705748 0.246358165844083 no 822 0.247152668782677 1196 877755 SGTC_619 1652-1634 108 µM 0.681740947275526 0.246917733232603 no 823 0.247701385293525 1175 5400454 SGTC_19 0279-0214 38.434 µM 0.681211887564168 0.247088373773201 no 824 0.247868713586382 1276 3566274 YBR002C RER2 SGTC_1092 toremifene 6.32 µM 0.681011405725597 0.247153052761501 no 825 0.247932136714406 1230 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2946 9065502 71.43 µM 0.680952261704613 0.247172135398673 no 826 0.247950848785728 1053 16489101 SGTC_1801 st050089 28.441 µM 0.68084167403353 0.247207818285925 no 827 0.247985838695788 1240 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1318 1280-3875 124 µM 0.680126803036935 0.247438549331809 no 828 0.248212087242229 1217 373245 SGTC_1094 duloxetine 25.4 µM 0.679903509130938 0.247510643030096 no 829 0.248282779780545 1226 60834 A selective serotonin reuptake inhibitor. SGTC_2790 5423970 71.43 µM 0.679592429484163 0.24761109834271 no 830 0.248381282267101 1233 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2284 7945075 39.21 µM 0.677429197816437 0.24831026123436 no 831 0.249066839114884 1286 1245402 SGTC_1920 st075728 45.7 µM 0.677242337605764 0.248370704353667 no 832 0.249126104795438 1235 3400306 SGTC_3163 9099914 49.47 µM 0.676925809253221 0.248473108734499 no 833 0.249226513897622 1237 16268368 SGTC_2325 6158266 200 µM 0.676282057647779 0.24868144694073 no 834 0.24943079111129 1237 3623240 SGTC_1107 amlodipine 47 µM 0.675069640434612 0.249074075639503 no 835 0.24981576051094 1133 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.674559828707415 0.249239271300295 no 836 0.249977731217164 1180 279621 SGTC_1079 idarubicin 2.36 µM 0.674490759476595 0.249261656468802 no 837 0.249999679274407 1205 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_293 4049-0273 38.5 µM 0.672556867427831 0.249888859911015 no 838 0.250614625038141 1155 1380311 SGTC_2583 asiatic acid 100 µM 0.672218168270384 0.249998793588238 no 839 0.250722408178552 1253 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2588 indole-3-carbinol 100 µM 0.672212711418968 0.25000056496224 no 840 0.250724144895688 1226 3712 Induces cell cycle arrest. SGTC_1785 bathophenanthroline 24 µM 0.671375679202596 0.250272356739615 no 841 0.250990617193595 1187 72812 An iron chelator. SGTC_2371 9071574 200 µM 0.670903558181554 0.250425727697583 no 842 0.251140984742208 1207 45596039 SGTC_1984 st072354 53.1 µM 0.669983711450923 0.250724687684744 no 843 0.251434086889162 1179 5762938 SGTC_722 3534-0461 190 µM 0.669829928547815 0.250774687200271 no 844 0.25148310627162 1219 658262 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.669567783367384 0.250859930768382 no 845 0.251566678532757 1237 4174840 SGTC_1732 st034308 51.822 µM 0.669047815078241 0.251029057842087 no 846 0.251732488577246 1163 830119 SGTC_2456 5770359 74.46 µM 0.668871094283182 0.251086552525162 no 847 0.251788855310477 1247 3118787 SGTC_2108 5365811 200 µM 0.666561453339772 0.251838615582854 no 848 0.252526148913066 1264 780283 SGTC_2439 5492030 7.2 µM 0.666459105932743 0.251871969340485 no 849 0.252558846996564 1213 5722370 SGTC_2372 9071633 200 µM 0.663571814050514 0.252813862086867 no 850 0.253482201066668 1266 21321366 SGTC_3155 9099265 49.47 µM 0.66348352918893 0.252842691574686 no 851 0.253510462430353 1205 25236499 SGTC_1108 betulinic acid 729.144 nM 0.663363471935846 0.252881899137545 no 852 0.25354889728934 1253 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1439 4092-1168 46 µM 0.662831915208479 0.253055530123146 no 853 0.253719105440624 1245 2886240 SGTC_1628 st004252 77.7 µM 0.661909076476858 0.253357120788057 no 854 0.254014747246797 1243 692968 SGTC_738 1315-0003 72.4 µM 0.661090652044428 0.253624746066967 no 855 0.254277089899486 1254 6251474 SGTC_892 0929-0076 29 µM 0.660061182487988 0.253961593967219 no 856 0.254607283821882 1252 5751038 SGTC_2595 hexamethylquercetagetin 100 µM 0.659789234516109 0.254050615968868 no 857 0.254694546389554 1190 386331 SGTC_2771 fluoxetine 41.05 µM 0.659513883339188 0.25414076868407 no 858 0.254782916930367 1264 3386 A selective serotonin reuptake inhibitor. SGTC_45 0kpi-0036 14.9 µM 0.659385031729396 0.254182961745563 no 859 0.25482427576706 1254 2795021 SGTC_1494 4358-1428 177 µM 0.6586155970431 0.254434993172154 no 860 0.255071322326157 1293 1564571 SGTC_1906 st060206 94.7 µM 0.658580599379504 0.254446459910586 no 861 0.255082562193522 1238 5133468 SGTC_602 3130-1533 38.1 µM 0.658095557397856 0.254605408386036 no 862 0.255238365194627 1274 720941 SGTC_1824 st053723 68.6 µM 0.657861238402715 0.254682213452909 no 863 0.255313649907173 1233 675225 SGTC_1463 k081-0032 34.1 µM 0.657249776074255 0.254882695667395 no 864 0.255510162238365 1129 977755 SGTC_419 nsc-638432 893 µM 0.656790163370547 0.255033444791503 no 865 0.255657925000317 1261 368090 SGTC_3171 9103192 49.47 µM 0.656338365460067 0.255181676176851 no 866 0.255803218833026 1293 13018434 SGTC_1842 st055362 61.2 µM 0.655440678057046 0.255476334076557 no 867 0.256092034258947 1248 676032 SGTC_1229 0139-0193 12.2 µM 0.654599893312955 0.255752475323791 no 868 0.256362696401739 1297 3090752 SGTC_489 paxilline 115 µM 0.652123058579349 0.25656685372645 no 869 0.257160894985284 1232 105008 A toxic potassium channel blocker. SGTC_2525 harmine 47.85 µM 0.649550818502526 0.257414028702029 no 870 0.25799120518957 1232 5280953 A monoamine oxidase inhibitor SGTC_214 4373-3496 70 µM 0.647444148729145 0.258108947784768 no 871 0.258672265279265 1341 3779166 SGTC_883 0850-0245 24.6 µM 0.64705048728773 0.258238911164128 no 872 0.258799634252063 1331 6823229 YPR165W RHO1 SGTC_1138 3761-0006 1.03 µM 0.644780449638961 0.258989002555618 no 873 0.25953473652851 1261 12061087 SGTC_2059 5238311 157 µM 0.644179823891019 0.259187656430786 no 874 0.259729416328904 1269 703021 SGTC_1553 gossypol 38.6 µM 0.644148611580151 0.259197981894445 no 875 0.259739535181658 1203 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_330 1488-0319 80.1 µM 0.643999968025477 0.2592471581532 no 876 0.259787727363733 1267 6846614 SGTC_1641 st009299 47.1 µM 0.643745920190843 0.259331216834347 no 877 0.259870103670453 1229 4046054 SGTC_3261 9137475 49.47 µM 0.642646317685229 0.259695212751515 no 878 0.260226810717535 1191 17027690 SGTC_3070 9117005 49.47 µM 0.641777104371581 0.259983130585288 no 879 0.260508958806931 1324 8779016 SGTC_661 1304-0007 33.6 µM 0.641537004489132 0.260062690170556 no 880 0.260586923384614 1287 3117130 SGTC_2767 sibutramine 71.45 µM 0.639316156695587 0.260799185702955 no 881 0.26130863997949 1350 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2474 5321570 43.32 µM 0.638507485651109 0.261067630000795 no 882 0.261571691394522 1309 2841384 SGTC_2996 9066192 71.4286 µM 0.63702428475594 0.261560358359933 no 883 0.262054512666859 1260 6472854 SGTC_2380 9035439 200 µM 0.636968111697569 0.261579028769205 no 884 0.262072807462752 1347 6462575 SGTC_2398 5228213 48.84 µM 0.636081906578394 0.261873669944005 no 885 0.262361518939477 1300 80771 YMR134W ERG29 SGTC_458 nppb 133 µM 0.635474261252438 0.262075795228955 no 886 0.26255957417081 1354 4549 A chloride channel blocker. SGTC_2625 euphol 100 µM 0.634915464256614 0.262261742306445 no 887 0.262741775349396 1291 6708538 A triterpene alcohol. SGTC_1957 st077035 62.4 µM 0.634651935571307 0.262349458401352 no 888 0.262827723869789 1353 705593 SGTC_3026 9090633 49.47 µM 0.63109117098453 0.26353613785149 no 889 0.263990456838965 1268 25236842 SGTC_2148 5546263 113.568 µM 0.629705409373707 0.263998703523609 no 890 0.264443671366201 1293 792097 SGTC_532 1548-0774 215 µM 0.629356476484107 0.264115242105998 no 891 0.264557852544481 1407 5932993 SGTC_1201 1889-3372 45.9 µM 0.628936251733415 0.264255625926254 no 892 0.264695395817088 1233 5392199 SGTC_3268 9137683 49.47 µM 0.628282748072312 0.264474016330945 no 893 0.264909365564907 1306 1953228 SGTC_2315 7733312 200 µM 0.628261221344502 0.264481211779159 no 894 0.264916415327492 1278 726316 SGTC_3106 9121286 49.47 µM 0.628035485729666 0.264556671369773 no 895 0.264990346958223 1320 15943471 SGTC_428 3448-4153 16.5 µM 0.627947417534646 0.264586114044935 no 896 0.265019193389691 1253 3834874 SGTC_2493 resveratrol 26.09 µM 0.627670606974807 0.264678667311758 no 897 0.265109872114197 1232 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1731 st035964 63 µM 0.625903407810602 0.265269928774253 no 898 0.265689149587122 1332 6739575 SGTC_2649 anisomycin 9.56 µM 0.625251889875007 0.265488079735604 no 899 0.265902875130547 1265 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3250 9135583 49.47 µM 0.624980396217743 0.265579012154029 no 900 0.265991962284284 1331 7699353 SGTC_2253 7938677 135.83 µM 0.623661196622482 0.266021081515926 no 901 0.266425055792312 1393 2301972 SGTC_1900 st060200 72.8 µM 0.622654462864996 0.266358692831375 no 902 0.26675580654099 1301 688945 SGTC_2584 androsterone 48.74 µM 0.622465931877749 0.266421941382049 no 903 0.266817769281704 1337 2754130 A steroid. SGTC_2529 gangaleoidin 93.61 µM 0.620189511263453 0.267186236355163 no 904 0.267566513065869 1365 4565183 SGTC_340 k038-0059 454 µM 0.619249012827095 0.267502325980901 no 905 0.267876163939396 1312 23733424 SGTC_2699 st077704 54.6 µM 0.616946309873771 0.268277030500711 no 906 0.268635069906942 1330 645852 SGTC_2231 micatex 6.853 µM 0.616859235559486 0.268306347277183 no 907 0.26866378833164 1327 20737 An antifungal of unknown mechanism. SGTC_558 k064-0027 21.3 µM 0.616484871867283 0.268432408964515 no 908 0.268787276705915 1348 5088526 SGTC_1609 st001574 46.4 µM 0.615587772369984 0.268734615697749 no 909 0.269083311752845 1292 3960012 SGTC_2920 7982904 15.77 µM 0.615008727872154 0.268929769675323 no 910 0.269274478260735 1300 6456808 SGTC_3246 9135460 32.98 µM 0.614951936729891 0.268948913688457 no 911 0.269293231029888 1269 41446951 SGTC_3334 9142812 21.919 µM 0.614659990562744 0.269047338094682 no 912 0.26938964370758 1368 45283678 SGTC_365 0121-0052 13.6 µM 0.614314905926971 0.269163700488924 no 913 0.269503627214263 1324 3101739 SGTC_3018 9082602 49.47 µM 0.613898922790711 0.269304003382756 no 914 0.269641061039847 1311 17332089 SGTC_71 0417-1750 47.813 µM 0.613752408562492 0.269353428469631 no 915 0.269689475233934 1335 6811472 SGTC_1588 farnesol 29.9 µM 0.612485661688418 0.269780942228646 no 916 0.270108240829728 1333 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2914 7968218 45.32 µM 0.60816632349914 0.271241223307223 no 917 0.271538583813029 1332 2977111 SGTC_3201 9113999 49.47 µM 0.606709709518401 0.27173456202467 no 918 0.272021788704187 1384 16649224 SGTC_2367 9070478 135.38 µM 0.605804362636845 0.272041417694915 no 919 0.272322336204707 1341 572802 SGTC_3086 9117350 49.47 µM 0.603906961013145 0.272685076001287 no 920 0.272952750269096 1267 2679265 SGTC_1396 3511-0007 98.6 µM 0.603214071317237 0.272920314219926 no 921 0.273183143977989 1298 X1396 SGTC_836 0330-0104 1.35 µM 0.601756830532726 0.273415380172061 no 922 0.273668007330655 1344 46494820 SGTC_396 dithiazanine 1.25 µM 0.600880744440545 0.273713225279121 no 923 0.273959709603668 1297 10578 An antihelmenthic. SGTC_569 4130-2812 160 µM 0.600703079116765 0.273773646157009 no 924 0.274018883918836 1287 743552 SGTC_209 4077-0173 175.592 µM 0.600607252889333 0.273806237723769 no 925 0.274050803018705 1300 15993494 SGTC_1208 2323-2347 50.3 µM 0.599557926402345 0.274163250830014 no 926 0.274400447082562 1341 5412760 SGTC_2541 muurolladie-3-one 83.07 µM 0.597760731518479 0.274775245403328 no 927 0.274999797969712 1353 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_420 mitomycin C 81.9 mM 0.597027038129587 0.275025281753191 no 928 0.275244664414989 1335 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1047 2043-3044 82 µM 0.59644628837928 0.275223275674406 no 929 0.27543856276967 1308 669592 SGTC_1006 4099-6547 255 µM 0.595541714773102 0.275531809958809 no 930 0.275740711898369 1372 3146833 SGTC_3021 9087658 49.47 µM 0.593605891019322 0.276192656696756 no 931 0.276387869976689 1324 25237042 SGTC_991 3996-0057 64.7 µM 0.592950425802534 0.276416593953975 no 932 0.276607164834452 1358 715343 SGTC_1772 st048439 82.2 µM 0.592213039869934 0.276668625509644 no 933 0.27685396928025 1328 2927068 YDL195W SEC31 SGTC_944 3370-0224 231 µM 0.591909212537954 0.276772503574278 no 934 0.27695569221881 1334 4580514 SGTC_3183 9108214 49.47 µM 0.590118037812988 0.277385291317043 no 935 0.27755575829837 1285 4974831 SGTC_3040 9091894 49.47 µM 0.589256751564405 0.277680186247857 no 936 0.27784452605209 1299 25236966 SGTC_2355 9061122 103.12 µM 0.589184178486799 0.27770504146437 no 937 0.277868864689625 1355 5302957 SGTC_2744 captopril 92.04 µM 0.588309076040915 0.278004836759145 no 938 0.278162427350238 1392 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1562 morin hydrate 59.1 µM 0.588117207179 0.278070588887333 no 939 0.27822681206417 1378 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2616 abietic acid 100 µM 0.588032771380726 0.278099526853498 no 940 0.278255148170455 1366 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1182 1222-0449 220 µM 0.587920388473444 0.27813804517432 no 941 0.27829286532779 1375 658318 SGTC_2270 7924575 90.91 µM 0.586739039589671 0.278543100190079 no 942 0.278689492020884 1405 1262135 SGTC_3245 9134821 49.47 µM 0.585621080292874 0.278926684928256 no 943 0.27906508954187 1307 17014901 SGTC_2537 larixol 68.93 µM 0.582721261986422 0.279922842193421 no 944 0.280040478788322 1344 6708759 SGTC_320 4092-0846 5.34 µM 0.581749328188872 0.280257110406267 no 945 0.280367769945605 1399 1359356 SGTC_1993 st073995 70.8 µM 0.581318290318782 0.280405415143075 no 946 0.280512977862925 1392 3098394 SGTC_1031 k035-0009 16 µM 0.580947599723357 0.280532986919723 no 947 0.280637885111837 1404 5180959 SGTC_2386 9075165 157.42 µM 0.580710347822952 0.280614651009603 no 948 0.280717843213194 1326 16452277 SGTC_1322 1348-1070 12 µM 0.58061273873991 0.280648252212105 no 949 0.28075074240544 1350 6758089 SGTC_319 1348-1596 45.5 µM 0.580295355779917 0.280757522393074 no 950 0.280857729384277 1454 5380505 SGTC_3331 9141060 1.957 µM 0.580035076827516 0.280847147875 no 951 0.280945481816144 1332 4906567 YPR165W RHO1 SGTC_427 1354-0053 47.3 µM 0.579018796858865 0.281197230117013 no 952 0.281288245024059 1448 6813657 SGTC_774 k060-0086 136 µM 0.578845814524821 0.281256839051092 no 953 0.281346607294829 1397 5911235 SGTC_625 k213-0058 121 µM 0.577597168346436 0.281687297771253 no 954 0.281768059577663 1433 3655420 SGTC_529 4076-0302 30.3 µM 0.577528787376496 0.281710880621488 no 955 0.281791148813749 1351 5816522 SGTC_2012 4023501 200 µM 0.577500106714088 0.281720772132836 no 956 0.281800833279284 1341 3477460 SGTC_2186 6124449 200 µM 0.577429305754102 0.281745190992049 no 957 0.281824740996022 1373 3834182 YLR033W RSC58 SGTC_3019 9081971 49.47 µM 0.575143729919679 0.282534021029334 no 958 0.282597047520763 1451 16451803 SGTC_1504 k297-0033 30 µM 0.57383673575784 0.282985585930304 no 959 0.283039143564533 1278 4388117 SGTC_2793 7325131 81.82 µM 0.573745444354252 0.28301713994091 no 960 0.283070035649049 1403 4176441 SGTC_403 arphamenine a 50 µM 0.573502938067953 0.283100968147253 no 961 0.283152105173049 1353 5487158 An arginine aminopeptidase inhibitor. SGTC_1156 4092-0367 4.88 µM 0.571106019664807 0.283930161648742 no 962 0.283963889169188 1382 1357585 SGTC_2874 9043904 71.43 µM 0.570657760654492 0.284085361946508 no 963 0.284115828242691 1358 4463428 SGTC_2066 5222451 176 µM 0.569621858995743 0.28444417636791 no 964 0.284467099672728 1348 2281147 SGTC_770 0389-1121 67.2 µM 0.568813173696989 0.284724438251338 no 965 0.284741466775002 1483 6753108 SGTC_1206 3978-0017 132 µM 0.568578743749642 0.28480570806156 no 966 0.284821026717384 1454 3873677 SGTC_2619 obliquin 87.91 µM 0.565539641504038 0.285860273969043 no 967 0.285853384504163 1397 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.564056430836282 0.286375620123588 no 968 0.286357864092973 1396 5282362 SGTC_1189 1431-2119 7.28 µM 0.563819669722275 0.286457924305868 no 969 0.286438431974506 1407 3107275 SGTC_1834 st055981 52.8 µM 0.56224938214389 0.287004080087758 no 970 0.28697306015227 1463 471719 YDL150W RPC53 SGTC_1075 aripiprazole 15.2 µM 0.562219410928082 0.287014509057844 no 971 0.286983268901869 1400 60795 An atypical antipschotic. YIL048W NEO1 SGTC_3271 9137798 49.47 µM 0.561407749598771 0.287297007992476 no 972 0.287259801129434 1383 6498326 SGTC_976 1348-1067 47.6 µM 0.560697597291277 0.287544284551985 no 973 0.287501852714732 1411 5310671 YGL099W LSG1 SGTC_473 2-arachidonoylglycerol 10 µM 0.55969639142992 0.287893077420704 no 974 0.287843272074506 1352 5282280 An endocannabinoid. SGTC_1718 roemerine 11.9335 µM 0.559038954049483 0.288122219324291 no 975 0.288067567686541 1344 235224 An aporphine alkaloid with mutagenic activity. SGTC_2109 5483026 200 µM 0.558439435547606 0.288331249287565 no 976 0.288272175194526 1440 759335 SGTC_979 1426-2828 121 µM 0.557836903708356 0.288541401908188 no 977 0.288477880143876 1475 747872 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.555678716835263 0.289294731543061 no 978 0.289215254302147 1421 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3069 9117009 49.47 µM 0.552331228453893 0.290465020148374 no 979 0.290360719357101 1336 41904981 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.552216283920589 0.29050524430778 no 980 0.290400089510781 1486 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1505 k297-0037 20.6 µM 0.550474987416807 0.291114919357866 no 981 0.290996814054279 1386 4089396 SGTC_1685 st024049 53.0905 µM 0.550453661610865 0.29112238980251 no 982 0.291004125740106 1389 1941139 SGTC_1283 0922-0125 16.4 µM 0.549795633577792 0.291352941467392 no 983 0.291229776935573 1468 3360884 SGTC_2093 5331342 194.4 µM 0.54947007107887 0.29146703949565 no 984 0.291341449133961 1447 33839 SGTC_1046 2001-0062 216 µM 0.548803836450274 0.29170059588232 no 985 0.291570038597849 1400 739778 SGTC_983 1491-0821 12.2 µM 0.547914000149926 0.292012674445619 no 986 0.291875477634408 1450 46495113 SGTC_1705 st027868 56.3335 µM 0.547042748322204 0.292318385686237 no 987 0.29217468181525 1442 292948 SGTC_3303 9125618 40.5795 µM 0.546825725351176 0.292394559450139 no 988 0.292249233761009 1489 22695467 SGTC_2546 rhodinyl acetate 100 µM 0.545849445203235 0.292737342025899 no 989 0.29258471587465 1424 6708682 SGTC_3122 9126309 49.47 µM 0.545685065749642 0.292795075790344 no 990 0.292641219681518 1443 17591206 SGTC_928 2764-0428 58.7 µM 0.544491056320331 0.293214597357177 no 991 0.293051800636067 1480 662578 SGTC_2866 9034245 58.44 µM 0.542754799732528 0.293825137098079 no 992 0.293649319062592 1444 6462273 SGTC_131 0141-0277 33.849 µM 0.542283059396847 0.293991122088558 no 993 0.293811761996431 1477 1547771 SGTC_1710 st031758 61.5 µM 0.541606295889717 0.294229321531799 no 994 0.294044876863458 1502 5394341 SGTC_819 1013-0258 27.7 µM 0.540494314584432 0.294620897406728 no 995 0.294428090402435 1415 5753198 SGTC_2622 2-methoxyxanthone 59.94 µM 0.538947512494899 0.295165991591038 no 996 0.294961535936868 1528 71034 A hepatoprotective. SGTC_2960 9079389 5.97 µM 0.538253145721406 0.295410837864815 no 997 0.295201146896903 1502 16457355 SGTC_987 1497-1013 404 µM 0.536437173883693 0.296051623643053 no 998 0.295828222749193 1424 1676435 SGTC_262 fenpropimorph 62.5 µM 0.536405817241134 0.296062693782589 no 999 0.295839055928522 1378 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_782 0083-0095 30.5 µM 0.535687828271702 0.296316224350635 no 1000 0.296087158575446 1428 3591729 An indicator and reagent. SGTC_1311 1190-0148 100 µM 0.53499771701319 0.296560004750474 no 1001 0.296325717976261 1509 1961333 SGTC_3270 9137563 49.47 µM 0.534577271657612 0.29670857124609 no 1002 0.29647110177732 1462 17015724 SGTC_2736 butenafine 14.65 µM 0.533349320131868 0.297142669126612 no 1003 0.296895896333564 1464 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1410 3909-8106 77.9 µM 0.532680907505512 0.297379084229064 no 1004 0.29712724237041 1481 1039210 SGTC_943 3253-1379 105 µM 0.531511238535731 0.297792998466407 no 1005 0.297532277728174 1508 668464 SGTC_2442 5158906 48.48 µM 0.530655704190857 0.298095915240295 no 1006 0.29782869342688 1542 1893835 SGTC_2819 7996655 46.38 µM 0.529955859721775 0.298343811653857 no 1007 0.298071267583534 1446 6456960 SGTC_742 0kpi-0133 140 µM 0.529526854962629 0.298495818568975 no 1008 0.298220010068348 1505 2728852 SGTC_1192 1488-0095 21.4 µM 0.529406291203833 0.298538543609359 no 1009 0.298261817443875 1450 915875 SGTC_595 3909-8003 73.7 µM 0.528562393024598 0.298837679685252 no 1010 0.298554527068369 1465 699517 SGTC_492 tmb-8 126 µM 0.527772780064399 0.299117696585112 no 1011 0.298828525902103 1376 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2032 5185112 25.99 µM 0.527005599435589 0.299389872425876 no 1012 0.299094850017083 1404 5718189 SGTC_3304 9125678 46.087 µM 0.526987949019229 0.299396135658465 no 1013 0.29910097856622 1425 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1746 st038117 42 µM 0.526657945568323 0.29951324799156 no 1014 0.299215572327799 1471 2898218 SGTC_2738 aclarubicin 5.55 µM 0.52473121740845 0.300197423546099 no 1015 0.299885026390031 1448 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1435 4092-0789 56.7 µM 0.524100900905365 0.300421400399601 no 1016 0.300104180993425 1515 2248285 SGTC_1492 4158-0558 28.5 µM 0.522542098599658 0.300975629612376 no 1017 0.300646471446859 1544 3967268 SGTC_3003 9075612 71.4286 µM 0.517592691734202 0.302738429357953 no 1018 0.302371240947352 1456 6501993 SGTC_2291 7917025 104.35 µM 0.5170007404808 0.302949570269377 no 1019 0.302577820958207 1402 2964612 SGTC_2783 7738165 71.43 µM 0.513369782170508 0.30424612273486 no 1020 0.303846339538352 1371 17201110 SGTC_2813 7971799 71.43 µM 0.511632160805217 0.304867470424009 no 1021 0.304454236366288 1511 2234054 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.511388766226632 0.304954549729457 no 1022 0.304539429760189 1428 5355888 SGTC_32 0928-0142 34.1 µM 0.511350803930317 0.304968132500399 no 1023 0.304552718345283 1449 2244242 SGTC_2627 acetyl isogambogic acid 100 µM 0.509860884549827 0.305501432295882 no 1024 0.30507446363849 1403 6857789 A caspase activator and apoptosis inducer. SGTC_759 3486-0358 89.3 µM 0.509518797759755 0.30562393672764 no 1025 0.305194312812994 1602 875103 SGTC_189 3970-0742 2.116 µM 0.509494368207042 0.305632686008228 no 1026 0.305202872439561 1493 2891807 SGTC_1750 st081859 2.357 µM 0.50939269998038 0.305669098994183 no 1027 0.30523849609662 1491 5291695 SGTC_2907 7721985 69.9 µM 0.506288058584474 0.306781965898131 no 1028 0.306327222373464 1424 3267881 SGTC_394 menadione 8.33 µM 0.505562785541841 0.307042199264872 no 1029 0.306581806001301 1466 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3009 9080819 71.4286 µM 0.505547360383056 0.307047734983082 no 1030 0.306587221518373 1461 17027216 SGTC_1453 4237-0541 195 µM 0.505472646711506 0.307074548543907 no 1031 0.306613452845269 1512 739892 SGTC_2155 5570423 76 µM 0.504447174665519 0.307442678536404 no 1032 0.306973587317861 1475 797402 SGTC_1350 1495-0454 146 µM 0.501694604484734 0.308431771120667 no 1033 0.30794118021345 1536 1069057 SGTC_392 N-ethylmaleimide 8.33 µM 0.501511258737191 0.308497703043042 no 1034 0.308005678097406 1447 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1260 0700-1617 7.75 µM 0.496202361593204 0.310409476802906 no 1035 0.309875822494694 1512 2853078 SGTC_1523 st012844 44.7 µM 0.496143654769119 0.310430646359786 no 1036 0.309896530567468 1510 4274103 SGTC_1527 coumarin 137 µM 0.496090195493545 0.310449924208022 no 1037 0.309915388160097 1535 323 A hepatotoxic, DNA x-linker. SGTC_1753 st043925 64 µM 0.494913156604148 0.310874505833876 no 1038 0.310330711610655 1520 670181 SGTC_2075 5212009 200 µM 0.49270919375796 0.31167019679246 no 1039 0.311109040279169 1524 780898 SGTC_2256 7954252 200 µM 0.490867932013497 0.312335617754062 no 1040 0.311759929663149 1466 2972920 SGTC_2341 7987486 176.74 µM 0.490458494813454 0.312483669225663 no 1041 0.311904746507399 1615 1258686 SGTC_1057 3448-5381 134 µM 0.488697699741168 0.313120713116817 no 1042 0.312527866274938 1599 5497911 SGTC_2871 9038510 12.99 µM 0.488091186316146 0.313340274975204 no 1043 0.312742626839104 1625 4945164 SGTC_2553 4-methylesculetin 85.09 µM 0.488088883294668 0.313341108810321 no 1044 0.312743442438054 1460 5319502 SGTC_2781 5567276 71.43 µM 0.48798682809658 0.313378060013361 no 1045 0.312779585493157 1547 2853274 SGTC_1787 fluconazole 80 µM 0.486892000027865 0.313774583028331 no 1046 0.31316743424647 1432 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_3181 9108277 49.47 µM 0.485557744818385 0.314258112295591 no 1047 0.313640380908328 1448 17097298 SGTC_1279 0874-0590 65.2 µM 0.484853346199982 0.314513512496574 no 1048 0.313890189166313 1527 3523074 SGTC_452 diindolylmethane 8 µM 0.484475946572955 0.31465038624377 no 1049 0.314024065460679 1518 3071 Inhibits expression of several cancer promoting factors. SGTC_2652 actinonin 100 µM 0.484218262461571 0.31474385669486 no 1050 0.31411548871467 1511 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_520 3584-0023 682 µM 0.484170242781606 0.314761276314937 no 1051 0.314132526786436 1478 1340790 SGTC_3012 9080433 71.4286 µM 0.483121900546917 0.315141675641251 no 1052 0.314504592333965 1589 17688859 SGTC_283 0987-0079 11.7 µM 0.482964390532661 0.315198846359772 no 1053 0.314560510268692 1548 411556 SGTC_3156 9099931 49.47 µM 0.482774737778425 0.315267689660806 no 1054 0.314627844904243 1559 18111053 SGTC_1244 0416-0015 52.5 µM 0.479365345645555 0.316506379692549 no 1055 0.315839371140784 1503 96201 SGTC_662 k832-1615 104 µM 0.478475680091829 0.316829949937973 no 1056 0.316155839929328 1565 5878478 SGTC_373 0844-0104 25.9 µM 0.477790683704486 0.317079177788893 no 1057 0.316399596324515 1589 5375804 SGTC_443 clozapine 122 µM 0.477539570107956 0.31717056330411 no 1058 0.316488975247233 1513 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_155 k072-0202 43.6 µM 0.477335490679591 0.317244840310428 no 1059 0.316561621182617 1465 5857737 SGTC_3266 9136860 49.47 µM 0.477228688695733 0.317283715029982 no 1060 0.316599642191476 1460 4871271 YPR165W RHO1 SGTC_2220 6782180 200 µM 0.475733965170397 0.31782798893664 no 1061 0.31713196000415 1518 833803 SGTC_2563 tomatine 8.54 µM 0.475468053984627 0.317924856513831 no 1062 0.31722669899724 1706 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_362 0310-0100 9.03 µM 0.474656943024986 0.318220409384797 no 1063 0.317515756060655 1523 790235 SGTC_237 nikkomycin 200 µM 0.474466677408046 0.318289755201172 no 1064 0.317583577481692 1592 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2670 beta-carotene 100 µM 0.474338169574572 0.318336595856723 no 1065 0.317629388402117 1495 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_544 k015-0020 52.4 µM 0.47371565680741 0.318563540684557 no 1066 0.317851343441196 1529 3008304 SGTC_2713 st079149 53.4 µM 0.47309227151258 0.31879087183343 no 1067 0.318073675177901 1557 3103253 SGTC_194 1486-1323 56.904 µM 0.470422331802866 0.319765294785221 no 1068 0.319026656143723 1490 5178754 SGTC_212 3807-4682 38.772 µM 0.4699455829222 0.319939420589806 no 1069 0.319196948189451 1626 3125501 YBL034C STU1 SGTC_1390 3413-2614 145 µM 0.469885807041693 0.319961255687234 no 1070 0.31921830249384 1525 3421432 SGTC_706 4262-0057 46.9 µM 0.469571187733221 0.320076190969829 no 1071 0.319330706816705 1472 883298 SGTC_310 1273-0058 1.06 µM 0.467986168997645 0.320655485211797 no 1072 0.319897240290366 1502 2734232 SGTC_226 1,3-diallylurea 8.28947 mM 0.467019930971766 0.321008841392827 no 1073 0.320242809207137 1537 74537 YKL182W FAS1 SGTC_848 0368-0089 85.6 µM 0.466916314601301 0.32104674384706 no 1074 0.320279876210848 1555 762535 SGTC_1484 3473-2379 286 µM 0.465661576040035 0.321505870104829 no 1075 0.320728879959834 1597 671917 SGTC_764 1951-2361 146 µM 0.464816698840874 0.321815176146159 no 1076 0.321031364148232 1488 5438930 SGTC_3031 9088762 49.47 µM 0.464746940221489 0.321840720010583 no 1077 0.321056344544931 1460 205253 SGTC_534 k292-0788 63.4 µM 0.464639698081034 0.321879991046533 no 1078 0.321094749281443 1628 4146317 SGTC_522 1273-0010 11.6 µM 0.462934452368798 0.322504702644687 no 1079 0.321705675769755 1576 5705015 SGTC_3205 9113483 49.47 µM 0.461325622151027 0.323094552556249 no 1080 0.32228250249434 1661 17018033 SGTC_2786 7743617 45.45 µM 0.460828983883013 0.323276726412062 no 1081 0.32246065273611 1438 583674 SGTC_1816 st051957 91.6 µM 0.459115118188487 0.323905721579075 no 1082 0.323075750342384 1541 674121 SGTC_1509 1326-1131 80 µM 0.458353147628153 0.324185529339968 no 1083 0.323349373238137 1584 768313 SGTC_809 3998-0021 90 µM 0.457601444423761 0.324461664102649 no 1084 0.323619402793519 1561 715485 SGTC_1429 4049-0205 9.46 µM 0.457394327589627 0.324537764503669 no 1085 0.323693820384937 1557 22774478 SGTC_586 0957-0265 8.15 µM 0.457262495282943 0.324586207122373 no 1086 0.323741191731323 1496 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2050 5263056 171 µM 0.456074674397515 0.32502281320607 no 1087 0.324168140506165 1629 763468 YGL055W OLE1 SGTC_1336 1486-0901 104 µM 0.455377848773795 0.325279056597746 no 1088 0.324418714293232 1575 5006114 SGTC_1026 k007-1105 30.6 µM 0.454810675830377 0.325487683873547 no 1089 0.324622724562973 1531 7066794 SGTC_2149 5554786 194.827 µM 0.453825185008826 0.32585031404398 no 1090 0.324977327564017 1558 745063 YPR165W RHO1 SGTC_41 0478-0632 82.643 µM 0.453678194342641 0.325904416199901 no 1091 0.325030231897694 1624 3750424 SGTC_1821 st053465 65.6 µM 0.453343963721387 0.326027448519413 no 1092 0.325150540069736 1511 675086 SGTC_1330 1469-0054 61.8 µM 0.450625313086747 0.327028902982429 no 1093 0.326129809790576 1687 7102664 SGTC_1540 guanosine 70.6 µM 0.450155228577686 0.327202192077743 no 1094 0.326299258155125 1567 6802 Guanosine is a purine nucleoside SGTC_1297 1068-0111 14.1 µM 0.449893036165749 0.327298861280723 no 1095 0.326393784562216 1500 767057 SGTC_950 1165-0508 94.1 µM 0.449471739084777 0.327454215942625 no 1096 0.326545695220921 1507 6148369 SGTC_3199 9111318 49.47 µM 0.44548722926915 0.328924991556282 no 1097 0.327983843387663 1614 8548020 SGTC_123 0083-0120 66.675 µM 0.444120474496568 0.329430104892134 no 1098 0.328477742169301 1489 16001701 SGTC_355 1311-2252 105 µM 0.443544175350117 0.329643181908617 no 1099 0.328686087045798 1533 5338538 SGTC_2780 5215298 71.43 µM 0.442501420808118 0.330028863588812 no 1100 0.329063201193031 1683 2834131 SGTC_2894 9048625 32.47 µM 0.442220407296908 0.330132832464147 no 1101 0.329164860045679 1694 4092861 SGTC_1409 3909-8004 61.9 µM 0.441142712566789 0.330531677600415 no 1102 0.329554841684204 1577 2119279 SGTC_372 0155-0182 15.9 µM 0.439882647235157 0.330998260625688 no 1103 0.330011052287397 1631 771486 SGTC_3322 9139058 2.11 µM 0.439539686280423 0.331125299343921 no 1104 0.330135266191663 1619 4908926 YPR165W RHO1 SGTC_2612 dictamnine 15.46 µM 0.439357575657321 0.331192764198073 no 1105 0.330201230791876 1560 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_956 1185-0240 191 µM 0.437436040011508 0.331904951504643 no 1106 0.330897575928115 1578 1416193 SGTC_1327 1436-0082 2.18 µM 0.436725150861304 0.332168585679425 no 1107 0.331155343485141 1569 15992205 SGTC_924 2046-0044 21.3 µM 0.435657666546338 0.332564619663908 no 1108 0.331542562323727 1519 3623589 SGTC_1861 st057647 17.4 µM 0.435436112606974 0.33264683905807 no 1109 0.33162295129528 1701 688668 SGTC_55 0767-0285 6.563 µM 0.434161180116683 0.333120127041868 no 1110 0.332085700386615 1578 3116166 SGTC_1975 st070967 30.8 µM 0.434117310577694 0.333136417288227 no 1111 0.332101627823799 1668 261391 SGTC_298 1391-0729 10 µM 0.432765434390803 0.333638568934691 no 1112 0.332592593572899 1568 3237558 SGTC_1077 5-fluorocytosine 377 nM 0.431314719158219 0.334177765817781 no 1113 0.333119774634088 1577 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_206 4546-0025 72.014 µM 0.429960967898849 0.334681232343752 no 1114 0.33361201722063 1577 6620745 YIL048W NEO1 SGTC_614 0462-0418 107 µM 0.4265526693127 0.335950109936967 no 1115 0.334852588941579 1513 5188303 SGTC_1997 st073024 93.8 µM 0.425928565077896 0.336182661293573 no 1116 0.335079949772506 1613 686268 SGTC_1550 gossypolone 36.6 µM 0.425508525773902 0.336339210057574 no 1117 0.335233003896228 1583 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1237 0330-0133 46.1 µM 0.424348019288988 0.336771878597871 no 1118 0.335656011948998 1576 X1237 YHR072W ERG7 SGTC_967 1306-0166 352 µM 0.423148905989969 0.337219167854827 no 1119 0.33609331117261 1705 4437607 SGTC_2077 5212015 200 µM 0.422713136663227 0.337381774141282 no 1120 0.336252284934992 1502 780900 SGTC_113 0099-0221 2.5 µM 0.422227459978055 0.3375630390325 no 1121 0.336429499995814 1699 89219 SGTC_1636 st007707 68.9 µM 0.422127046881653 0.337600520044071 no 1122 0.336466143540941 1700 403051 SGTC_335 4077-0256 27.6 µM 0.421838029083859 0.337708410175662 no 1123 0.336571622880802 1673 3121989 SGTC_1473 k844-0725 134 µM 0.420768015620851 0.338107961458854 no 1124 0.336962244677054 1644 54682906 SGTC_2798 7813637 45.45 µM 0.419232633464508 0.338681603603859 no 1125 0.337523062345164 1650 956368 SGTC_2720 fluspirilene 36.88 µM 0.41645236227245 0.339721307402633 no 1126 0.338539509635307 1661 3396 An atypical antipsychotic. SGTC_734 2023-0417 80 µM 0.415887931657749 0.339932529887986 no 1127 0.338746005445306 1650 3935732 SGTC_3036 9090181 49.47 µM 0.415374345108581 0.340124769068398 no 1128 0.338933942181919 1615 25236586 SGTC_2095 5432005 200 µM 0.414057662048113 0.340617802904307 no 1129 0.339415939112196 1586 783734 SGTC_2635 hydroquinidine 100 µM 0.413720955864292 0.340743926789707 no 1130 0.339539239058516 1606 442912 An experimental heart treatment. SGTC_1383 3049-0032 20.7 µM 0.411982859538115 0.341395268327172 no 1131 0.340175993278614 1716 712864 SGTC_1720 st037298 9.481 µM 0.411948335692212 0.341408210732799 no 1132 0.340188645767059 1590 597396 SGTC_1258 0671-0043 57.1 µM 0.410948390877137 0.341783154003048 no 1133 0.340555189062637 1557 4298767 SGTC_2471 5466956 24.79 µM 0.408184412996605 0.34282035738569 no 1134 0.341569145340995 1643 724419 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.407374906835255 0.343124355494095 no 1135 0.341866327031084 1645 1241132 A phosphatase inhibitor. SGTC_3081 9117243 49.47 µM 0.406948533209563 0.343284514671613 no 1136 0.342022894518238 1735 45595589 SGTC_2159 5658611 73.75 µM 0.406821361845555 0.34333228963747 no 1137 0.342069598026527 1694 793844 SGTC_3111 9122088 49.47 µM 0.404459014802669 0.344220216327799 no 1138 0.342937605396048 1698 16876704 SGTC_2160 5660466 132.927 µM 0.404070503041253 0.344366327238674 no 1139 0.343080437509272 1707 2859134 SGTC_3232 9132874 49.47 µM 0.403170710312162 0.344704809085855 no 1140 0.343411322573562 1570 3784940 SGTC_1450 4112-4260 37.6 µM 0.401165019955223 0.345459752033857 no 1141 0.344149316377316 1729 1633175 SGTC_2658 polymyxin b sulfate 77.05 µM 0.400951719734294 0.345540074595222 no 1142 0.344227835187671 1614 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_208 k072-0098 12.366 µM 0.400868268283147 0.345571501839264 no 1143 0.344258556667981 1624 5948901 SGTC_790 1575-0012 79.1 µM 0.400605724858599 0.345670380833149 no 1144 0.344355215046325 1685 378741 YLR208W SEC13 SGTC_977 1348-1378 135 µM 0.39932623035447 0.346152414100741 no 1145 0.344826421052184 1601 X977 SGTC_3164 9100705 49.47 µM 0.398934815127771 0.346299924651685 no 1146 0.344970617678932 1706 17174235 SGTC_2030 5175110 200 µM 0.398254881008659 0.346556223190127 no 1147 0.345221157640234 1689 2831986 SGTC_1139 k015-0024 46.9 µM 0.397533493561961 0.346828224214833 no 1148 0.345487046373006 1726 2766652 SGTC_1273 0849-0096 14.1 µM 0.397065468738871 0.347004736441467 no 1149 0.345659591594473 1610 5286025 SGTC_156 3474-0145 5.642 µM 0.395943515919619 0.347428008089526 no 1150 0.346073348886593 1776 2265471 SGTC_587 k089-0003 57 µM 0.395266473322683 0.347683523545154 no 1151 0.34632311975866 1671 9659696 SGTC_354 2783-3500 4.88 µM 0.394772076692087 0.347870152253845 no 1152 0.346505552111578 1567 6740761 SGTC_2806 7952793 58.44 µM 0.394737162163148 0.347883333457514 no 1153 0.346518436919109 1657 2972490 SGTC_2647 atorvastatin 60.16 µM 0.3942809842981 0.348055570149066 no 1154 0.346686800454627 1690 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.392432471004704 0.348753824231964 no 1155 0.347369348935415 1713 688761 SGTC_2327 6189656 200 µM 0.391581494262955 0.349075443114075 no 1156 0.347683731782593 1757 5349088 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.389769460811566 0.349760645647218 no 1157 0.348353514015443 1631 6708630 An antioxidant. SGTC_714 4296-0578 26.1 µM 0.389358223988459 0.349916219037717 no 1158 0.348505585503684 1737 1589775 SGTC_716 1683-5115 658 µM 0.388823656764337 0.350118486733529 no 1159 0.348703299805668 1683 723597 SGTC_1822 st052468 42 µM 0.388755218406595 0.350144385274426 no 1160 0.348728615291745 1620 2873678 SGTC_524 r073-0010 27.8 µM 0.386863114567428 0.350860673522356 no 1161 0.349428774673006 1603 2772106 SGTC_1115 galangin 695.678 nM 0.385272195986555 0.351463353543831 no 1162 0.350017879482153 1745 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2970 9090938 41.86 µM 0.384238065874649 0.351855308536117 no 1163 0.350401003619154 1793 17217104 SGTC_2181 6316240 54.2555 µM 0.384049274211604 0.351926881181849 no 1164 0.350470963530367 1583 12779990 SGTC_2216 7189485 200 µM 0.383590339740161 0.35210088931266 no 1165 0.350641050530788 1727 731273 SGTC_1164 k060-0068 93.7 µM 0.383135553893052 0.352273355019447 no 1166 0.350809629538333 1659 5963676 SGTC_480 am 92016 50 µM 0.382747032145257 0.35242071585713 no 1167 0.350953669185842 1603 2129 K+ channel blocker. SGTC_934 2950-0684 338 µM 0.382158254170601 0.352644073287951 no 1168 0.351171992182409 1762 1121253 SGTC_2490 carminic acid 95.39 µM 0.380348371986211 0.353330983806579 no 1169 0.351843416522361 1651 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3313 9133968 57.047 µM 0.379700913606277 0.353576832025207 no 1170 0.352083720957849 1660 1494643 SGTC_2047 4141938 200 µM 0.379569538609638 0.353626724248787 no 1171 0.352132488053566 1667 3807862 SGTC_1483 3453-0561 55.9 µM 0.379223625564357 0.353758103515988 no 1172 0.35226090444067 1702 4546991 SGTC_1317 1273-0028 910 nM 0.378822263693086 0.353910564316816 no 1173 0.352409926703129 1646 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_285 1486-1325 46 µM 0.378363180885803 0.354084979641839 no 1174 0.352580408041165 1720 22310230 SGTC_404 fumagillin 50 µM 0.378141254755715 0.354169305080552 no 1175 0.35266283138321 1688 12015870 A methionine aminopeptidase binder. SGTC_2606 farnesol 9.78 µM 0.37745331020942 0.354430749316761 no 1176 0.352918377857851 1745 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2074 5212007 75.395 µM 0.377326519713563 0.354478941860843 no 1177 0.35296548317935 1801 758611 SGTC_1060 3448-7350 82 µM 0.376665115526642 0.354730376623149 no 1178 0.35321124519677 1768 570178 SGTC_3 0833-0587 95.581 µM 0.375332452111219 0.355237184738719 no 1179 0.353706617024283 1666 5382644 SGTC_1560 lithocholic acid 53.1 µM 0.37479617864368 0.355441200349389 no 1180 0.353906028232918 1757 9903 A bile acid which acts as a detergent. SGTC_878 0828-0289 13.7 µM 0.374096793099681 0.355707331262808 no 1181 0.354166152253402 1648 745350 YLR208W SEC13 SGTC_952 1185-0122 232 µM 0.373858286898293 0.355798103982402 no 1182 0.354254875964915 1621 678600 SGTC_10 0279-0212 42.575 µM 0.373557186750012 0.355912710915703 no 1183 0.354366895766464 1639 39851 YBR002C RER2 SGTC_3072 9116419 49.47 µM 0.373174648729307 0.356058334106588 no 1184 0.35450923148128 1618 17170162 SGTC_1371 2421-0008 32.7 µM 0.372558603222681 0.356292892216158 no 1185 0.354738493956684 1673 2827552 SGTC_1441 4106-0040 13 µM 0.371103421872709 0.35684716544478 no 1186 0.355280251221814 1667 2904180 SGTC_398 bronopol 33.3 µM 0.370803421861168 0.356961471976727 no 1187 0.355391976251004 1694 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.369376161090442 0.357505465113713 no 1188 0.35592368214624 1674 4000243 SGTC_1151 3909-8316 15.3 µM 0.369302573796508 0.357533520395336 no 1189 0.355951103664866 1653 800431 SGTC_349 k015-0014 24 µM 0.367808843618319 0.358103173816649 no 1190 0.356507887166004 1627 2196908 SGTC_2956 9076196 2.52 µM 0.367002484669061 0.358410820726749 no 1191 0.356808582319417 1695 16423868 SGTC_1832 st054113 55 µM 0.366891632262524 0.358453120994381 no 1192 0.356849926680435 1775 1251267 SGTC_3344 9148862 3.898 µM 0.366022979306376 0.358784651136547 no 1193 0.357173964308995 1749 4905352 SGTC_1003 4049-0218 100 µM 0.365928382062973 0.358820761556507 no 1194 0.357209258581655 1733 295161 SGTC_3139 9095020 49.47 µM 0.363554110582445 0.359727500060116 no 1195 0.358095499738079 1606 25236292 SGTC_200 k038-0079 37.545 µM 0.36141812344422 0.360543912753498 no 1196 0.358893450894265 1710 3436683 SGTC_3053 9095903 49.47 µM 0.361216590666376 0.360620975103251 no 1197 0.358968770343124 1736 17174018 SGTC_854 0422-0053 192 µM 0.356280938096593 0.362510035929645 no 1198 0.360815091585185 1648 3596728 SGTC_2754 granisetron 64.02 µM 0.353523167105749 0.363567002080148 no 1199 0.361848131880858 1822 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1725 st036284 20.55 µM 0.353067933702147 0.363741578762777 no 1200 0.362018755973597 1844 707914 SGTC_2752 diclazuril 33.15 µM 0.352179493525516 0.364082366631491 no 1201 0.362351827416718 1794 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1870 st057514 26.5 µM 0.352077662741243 0.364121433754481 no 1202 0.362390009892324 1681 5393161 SGTC_2645 abamectin 100 µM 0.351683457424478 0.364272682938283 no 1203 0.362537834040446 1772 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_255 tunicamycin 200.472 nM 0.351652558674179 0.364284539102747 no 1204 0.362549421715206 1815 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2214 7179297 48.276 µM 0.351242372197529 0.364441944123173 no 1205 0.362703262111542 1759 769744 SGTC_543 3844-1095 191 µM 0.349682168417256 0.365040865612093 no 1206 0.363288618689473 1789 4230703 SGTC_2319 6033012 152.6 µM 0.348658295252069 0.365434082892921 no 1207 0.363672928658834 1621 847246 SGTC_3242 9133940 49.47 µM 0.348582291730077 0.365463277601835 no 1208 0.363701461994987 1745 17248444 SGTC_1113 artemisinin 1.17947 µM 0.345988558931952 0.366460056479738 no 1209 0.364675656507826 1857 2240 An anti-malaria and mitochondrial poison. SGTC_2207 7258803 200 µM 0.345397702474649 0.366687250608058 no 1210 0.36489770209103 1777 3666799 SGTC_442 cape 100 µM 0.344680976874378 0.366962906210737 no 1211 0.36516711048917 1819 5281787 SGTC_3125 9127534 49.47 µM 0.343287131160961 0.367499181319434 no 1212 0.365691230552657 1727 1639235 SGTC_3051 9093778 49.47 µM 0.342023246140763 0.367985678219058 no 1213 0.366166699095782 1738 17217378 SGTC_29 0299-0004 12.984 µM 0.341260645981162 0.368279322164123 no 1214 0.366453685743901 1720 16871 A napthoquinone isolated from Swertia calycina. SGTC_2136 5328288 199.296 µM 0.341170318894431 0.368314108273015 no 1215 0.366487683170824 1676 262395 SGTC_2693 st077581 40.7 µM 0.340666554066964 0.368508134301291 no 1216 0.366677310043688 1745 25238761 SGTC_1812 st052057 4.327 µM 0.339457009917223 0.368974129466078 no 1217 0.367132738772741 1676 3645418 SGTC_762 1165-0429 115 µM 0.337661829212068 0.369666104972965 no 1218 0.367809021399014 1829 5967793 SGTC_1249 0481-0015 10.2 µM 0.33712512922614 0.369873064994737 no 1219 0.368011287371989 1684 4227577 SGTC_2506 ethyl hematommate 54.16 µM 0.337007053446991 0.369918601947553 no 1220 0.36805579147137 1645 3940691 An allergen. SGTC_1052 3253-3998 198 µM 0.335762881766615 0.370398538345061 no 1221 0.368524841417109 1691 5450317 SGTC_2096 5468907 200 µM 0.335567971440556 0.370473742862842 no 1222 0.368598339947586 1848 759785 SGTC_2472 5377652 49.4 µM 0.334096612133943 0.371041614084856 no 1223 0.369153328232784 1704 1610903 SGTC_1018 4259-0013 28.1 µM 0.333594077773274 0.371235631679789 no 1224 0.369342943880641 1740 6801262 SGTC_1689 st020265 53.493 µM 0.32644161086751 0.374000569775755 no 1225 0.372045129671246 1840 5758320 YPR016C TIF6 SGTC_2445 5742597 35.57 µM 0.326316761412733 0.374048891073331 no 1226 0.372092353963629 1687 1774255 SGTC_2839 9003951 25.97 µM 0.326299667395455 0.374055507236224 no 1227 0.372098819923525 1797 2990634 SGTC_179 1273-0063 6.77 µM 0.325094743728013 0.374521960919925 no 1228 0.372554683493119 1694 3108139 SGTC_2478 5763493 32.33 µM 0.324944016716172 0.374580323755503 no 1229 0.372611721224291 1791 1365576 YLR208W SEC13 SGTC_1775 st081588 35.1725 µM 0.324882958733994 0.374603966765454 no 1230 0.372634827425212 1725 1426443 YGL099W LSG1 SGTC_2307 7538926 6.34 µM 0.324679102921907 0.374682907688116 no 1231 0.372711975995473 1721 96582 SGTC_2551 apiole 73.87 µM 0.324482754731003 0.374758946332449 no 1232 0.372786288158732 1774 10659 A possible DNA adduct former. SGTC_1607 st000305 50.6 µM 0.323969106633775 0.374957886926925 no 1233 0.372980711630666 1811 5457690 SGTC_3092 9117248 49.47 µM 0.323469765609172 0.375151318160073 no 1234 0.373169750679102 1841 17141857 SGTC_2027 5150920 200 µM 0.322929186575762 0.375360759282573 no 1235 0.373374435912927 1806 786715 SGTC_1491 4138-0063 26.5 µM 0.321891608212027 0.375762859974824 no 1236 0.373767405402818 1847 23883227 SGTC_1878 temozolomide 1 mM 0.321236036469509 0.376016988317767 no 1237 0.374015762482756 1898 5394 DNA alkylating agent. SGTC_2020 4017018 200 µM 0.320671742448661 0.376235776485483 no 1238 0.374229581765381 1720 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_3142 9086498 49.47 µM 0.320460314622385 0.376317761563742 no 1239 0.374309704838709 1889 25236367 SGTC_110 0850-0284 111.64 µM 0.317846857123994 0.377331638166314 no 1240 0.375300552738683 1758 3906265 SGTC_1485 3909-9022 254 µM 0.317442650038462 0.377488523826973 no 1241 0.375453874649063 1818 714516 SGTC_937 3122-0005 46.7 µM 0.316758443654798 0.377754132208226 no 1242 0.375713449388261 1882 759535 SGTC_1820 st053765 18.6 µM 0.316669581525953 0.377788632661209 no 1243 0.375747166100889 1698 3690829 SGTC_171 k064-0041 9.68 µM 0.315660191667744 0.378180593593518 no 1244 0.376130222654308 1697 53325 SGTC_1696 st025591 34.7925 µM 0.315299379500353 0.378320732713463 no 1245 0.376267178040607 1751 2787147 SGTC_2514 salinomycin 42.74 µM 0.315218066431503 0.378352316846816 no 1246 0.376298044624998 1912 23682228 A polyether potassium ionophore. SGTC_962 1254-0300 21.5 µM 0.314632071742414 0.378579956610763 no 1247 0.376520512627188 1766 7340576 SGTC_2979 9012552 45.46 µM 0.312891749532075 0.379256262972007 no 1248 0.377181453006559 1811 17100905 SGTC_2290 7904846 200 µM 0.312148254694737 0.379545305224987 no 1249 0.377463927679228 1716 2962154 SGTC_402 epigallocatechin gallate 10 µM 0.312027232047758 0.379592360560458 no 1250 0.377509913806947 1729 65064 An antioxidant. SGTC_802 4112-3352 742 µM 0.310906904097828 0.380028044666377 no 1251 0.377935697854108 1875 704594 SGTC_1798 st045719 60.953 µM 0.310503369579713 0.380185012459075 no 1252 0.378089098737926 1851 3980186 SGTC_829 1635-0120 117 µM 0.309104933466219 0.380729131933932 no 1253 0.378620853237792 1873 285054 SGTC_77 0828-0286 12.516 µM 0.308605308497133 0.380923588991414 no 1254 0.378810891127095 1760 745345 SGTC_2909 7941780 10.49 µM 0.308044505284021 0.381141892818766 no 1255 0.379024233742415 1909 1243215 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.307943723649029 0.381181128090889 no 1256 0.379062577334582 1933 551469 SGTC_813 k007-0158 173 µM 0.307931567946121 0.38118586050698 no 1257 0.379067202199227 1849 6523916 SGTC_1355 1499-0035 1.68 µM 0.306197028652105 0.381861327168824 no 1258 0.379727317311364 1738 1548538 SGTC_182 3448-4371 550.524 µM 0.304821979519153 0.382397056490639 no 1259 0.380250870228911 1964 3491403 SGTC_2742 clothiapine 36.27 µM 0.30451354497098 0.382517255829316 no 1260 0.380368337517501 1887 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2923 7992654 58.14 µM 0.304429664214346 0.382549946769821 no 1261 0.380400285409929 1755 2985126 SGTC_2431 5490079 200 µM 0.303749493823935 0.382815061222523 no 1262 0.380659373871586 1727 5722345 SGTC_2305 7443522 69.23 µM 0.302996529396455 0.383108613123698 no 1263 0.380946253248777 1832 5415886 SGTC_2190 6049624 200 µM 0.301341439675051 0.38375410478717 no 1264 0.381577072147231 1838 2265554 SGTC_299 1273-0059 1.44 µM 0.298653632290001 0.38480304734465 no 1265 0.382602169611151 1851 2848077 SGTC_859 0439-0102 54.6 µM 0.298393379806859 0.384904658293311 no 1266 0.382701470604172 1919 610143 SGTC_130 0136-0219 337.655 µM 0.297692401589808 0.385178382060654 no 1267 0.382968971650608 1926 234244 SGTC_554 4483-2211 187 µM 0.297489765318538 0.385257519813652 no 1268 0.383046310301604 1786 747107 SGTC_1503 4585-0012 61.3 µM 0.2968458897738 0.385509011252733 no 1269 0.383292084333952 1863 2922052 SGTC_2099 5377090 177.372 µM 0.296355019983955 0.385700772502529 no 1270 0.383479486034005 1760 2243829 SGTC_868 0527-0199 213 µM 0.294721883585784 0.386338967967474 no 1271 0.3841031723185 1790 2849450 SGTC_2014 4013930 200 µM 0.293339591998645 0.386879378990519 no 1272 0.384631296964598 1920 64556 SGTC_2580 diallyl disulphide 81.36 µM 0.293293671090538 0.386897335677528 no 1273 0.384648845397826 1796 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1603 st002045 67.8 µM 0.293258731172851 0.386910998574008 no 1274 0.38466219766172 1904 5887985 SGTC_2065 5221596 34.26 µM 0.29314597043229 0.386955093461037 no 1275 0.384705290029117 1817 788581 SGTC_889 0919-1524 82.7 µM 0.292789033375895 0.387094682678847 no 1276 0.384841705605736 1774 3905452 SGTC_2704 st078022 71.1 µM 0.292009814463224 0.387399466556654 no 1277 0.385139559999643 1912 54697681 SGTC_2056 5235370 200 µM 0.291153241106163 0.387734586960783 no 1278 0.385467061130059 1765 5511916 SGTC_2041 5107442 45.335 µM 0.29035043103825 0.388048749294354 no 1279 0.385774080636653 1902 793005 SGTC_1520 flindersine 88 µM 0.288842304400167 0.388639119980774 no 1280 0.386351028482779 1946 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1555 citronellol 128 µM 0.28719728705805 0.389283371230283 no 1281 0.386980631738066 1932 8842 A terpine precursor. SGTC_87 0100-0052 35.5 µM 0.284749524310166 0.390242571175796 no 1282 0.387918022813983 1856 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2869 9037858 32.47 µM 0.284423191073958 0.390370501369663 no 1283 0.388043044326354 1777 27187042 SGTC_2805 7950783 58.44 µM 0.283100161622451 0.390889281076394 no 1284 0.388550028851268 1830 1178958 YDL195W SEC31 SGTC_412 gemfibrozil 100 µM 0.282443924218617 0.391146673737999 no 1285 0.388801569362675 1912 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2219 9098279 200 µM 0.279948126961771 0.392126022233687 no 1286 0.389758651412562 1911 902349 SGTC_1964 st076914 61 µM 0.278238988711402 0.392797081323825 no 1287 0.390414453680623 1849 24208661 SGTC_2302 7771753 200 µM 0.278093305671496 0.392854295639214 no 1288 0.390470367220421 1740 2203047 SGTC_1407 3909-7909 12.3 µM 0.27794064256496 0.392914253730532 no 1289 0.390528962159118 1805 4411780 SGTC_440 fluspirilene 35.1 µM 0.277884795644132 0.392936188117755 no 1290 0.39055039786687 1888 3396 An atypical antipsychotic. SGTC_580 1123-0028 41 µM 0.277780239349819 0.392977254469392 no 1291 0.390590530573976 1853 1677248 YPR107C YTH1 SGTC_1119 parthenolide 318.541 nM 0.277664282803237 0.39302279986671 no 1292 0.390635040497356 1883 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_3064 1327-0027 10 µM 0.276502888019726 0.39347905304975 no 1293 0.391080920881755 1824 16000455 YPR107C YTH1 SGTC_487 nimodipine 119 µM 0.275005534962566 0.3940675030601 no 1294 0.391655992960707 1927 4497 L-type voltage-gated calcium channels inhibitor SGTC_2851 9015922 71.43 µM 0.273842208655536 0.394524849792436 no 1295 0.392102942575936 1903 2996893 SGTC_2374 9071832 200 µM 0.273488490439177 0.394663938406789 no 1296 0.392238869266084 1897 17381698 SGTC_2165 5727197 32.143 µM 0.272308994239137 0.39512783531155 no 1297 0.392692220523878 1857 1361712 SGTC_1835 st008666 49.2 µM 0.270962986662171 0.395657402910475 no 1298 0.393209749999199 1769 690455 SGTC_346 4513-0042 7.16 µM 0.270351556183474 0.395898025270368 no 1299 0.393444902685465 1788 2827372 SGTC_465 cgp-37157 41 µM 0.270202627218823 0.39595664078981 no 1300 0.39350218580932 1923 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1770 st043884 66.3 µM 0.268990298018292 0.396433877199486 no 1301 0.393968574334151 1827 670149 SGTC_2164 5685496 200 µM 0.268971158083843 0.396441412928781 no 1302 0.393975938774889 1913 759046 SGTC_793 0488-0545 106 µM 0.26891160001745 0.39646486223596 no 1303 0.393998855075546 1782 292548 SGTC_1502 4534-4282 27.7 µM 0.268585058332656 0.396593435458817 no 1304 0.394124505826769 1836 3278949 SGTC_391 gliotoxin 8.33 µM 0.268494237709281 0.396629197364939 no 1305 0.394159454869712 1873 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_3217 9129673 49.47 µM 0.26827295602609 0.39671633379991 no 1306 0.394244610715866 1837 17248312 SGTC_1700 st030840 7.9285 µM 0.26762820030464 0.396970255491397 no 1307 0.39449276091715 1956 5499307 SGTC_3059 1327-0034 3 µM 0.264787725131685 0.398089427803083 no 1308 0.395586496707945 1781 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2983 9022671 12.99 µM 0.264604447232365 0.398161669826386 no 1309 0.39565709691187 2002 6405161 SGTC_2436 5633522 8.09 µM 0.26369002637091 0.398522156085809 no 1310 0.396009390709426 1974 5724242 SGTC_93 0109-0045 59.227 µM 0.263291957259962 0.398679111388229 no 1311 0.396162779121436 1963 88733 SGTC_1903 st060211 78.3 µM 0.262061959061734 0.39916419278157 no 1312 0.396636837179444 1961 688960 SGTC_1715 st032160 10.2275 µM 0.26019780165812 0.399899667831269 no 1313 0.397355599950475 1925 5289825 SGTC_2963 9082507 9 µM 0.258995881470905 0.400374055757461 no 1314 0.397819209107603 1870 16459611 SGTC_84 0443-0269 128.823 µM 0.25858748532113 0.40053527982785 no 1315 0.397976770086553 1930 6150058 SGTC_1376 2910-0861 41.3 µM 0.258219758493209 0.40068046321954 no 1316 0.398118654905279 1880 1112859 SGTC_272 doxorubicin 8.13 µM 0.257279044823604 0.401051931761827 no 1317 0.39848168395779 1941 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1252 0493-0875 34.8 µM 0.256873298627344 0.401212180254108 no 1318 0.398638291855258 1815 3960963 SGTC_1036 k216-0215 33.5 µM 0.256051556713674 0.401536776149583 no 1319 0.398955513690301 1784 622330 SGTC_2285 7945142 200 µM 0.255675291553295 0.401685427171895 no 1320 0.399100787822436 1824 2970608 SGTC_1204 4049-0315 18.3 µM 0.25473199303921 0.402058158474843 no 1321 0.399465052147928 1948 588402 SGTC_1401 3807-4679 7.6 µM 0.253606168948661 0.402503128813854 no 1322 0.399899915143136 1843 3291456 SGTC_1548 st061468 90.8 µM 0.253587150250044 0.402510646844798 no 1323 0.399907262410573 1961 390799 SGTC_2426 5582046 32.21 µM 0.253416544680841 0.402578088294593 no 1324 0.399973172013571 1901 2251934 SGTC_120 rhodamine 6G 52.259 µM 0.253373314273608 0.402595178005776 no 1325 0.399989873556237 1918 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1664 st014217 9.02 µM 0.252928794540278 0.402770914966521 no 1326 0.400161618961681 1969 3982782 SGTC_3093 9117344 49.47 µM 0.252705822858998 0.402859072257498 no 1327 0.400247773956778 1878 24824913 SGTC_565 1418-0001 44.5 µM 0.251897300649149 0.403178782619758 no 1328 0.400560223049101 1944 2862145 SGTC_2941 9056145 11.23 µM 0.250686587720289 0.403657650460701 no 1329 0.401028215540353 1987 2119517 SGTC_1919 st067113 52.3 µM 0.250540947850105 0.403715264491627 no 1330 0.401084521183725 1845 1268243 SGTC_600 1495-0418 41.6 µM 0.249559571531855 0.404103543950931 no 1331 0.40146398333388 1871 5377768 SGTC_1518 st038567 90.8 µM 0.248688439740884 0.404448284578728 no 1332 0.401800895859042 1939 77966 SGTC_2729 fluphenazine 10.66 µM 0.24840332402561 0.404561132052333 no 1333 0.401911180983446 1868 3372 An atypical antipsychotic. SGTC_2589 lobaric acid 100 µM 0.248230826763177 0.404629409521669 no 1334 0.401977908148826 1797 73157 A novel microtubule depolymerizer. SGTC_16 erodoxin 22.806 µM 0.248087144469249 0.404686283733576 no 1335 0.402033490992958 1918 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1228 0124-0032 52.5 µM 0.247054418266916 0.405095130161478 no 1336 0.402433054677129 1945 X1228 SGTC_3094 9117742 49.47 µM 0.246536239335399 0.40530031130671 no 1337 0.402633577505882 1921 17149698 SGTC_3104 9120930 49.47 µM 0.246164066144279 0.405447695234028 no 1338 0.402777615422671 1895 17014836 SGTC_276 colchicine 750 µM 0.246007949651004 0.405509522760736 no 1339 0.402838039326447 1900 2833 A microtubule depolymerizer. SGTC_1233 0325-0408 14.2 µM 0.243814930625888 0.406378282581101 no 1340 0.403687078134379 1939 12874 SGTC_3166 9102297 49.47 µM 0.243345474394375 0.406564316729865 no 1341 0.403868889713513 1830 25237072 SGTC_100 0086-0128 49.5915 µM 0.242976620697222 0.406710499325294 no 1342 0.404011754394391 1783 93297 SGTC_233 rapamycin 362 pM 0.242614493128757 0.406854028895828 no 1343 0.404152026362745 1981 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_390 dec-rvkr-cmk 16.7 µM 0.242379112849864 0.406947328780685 no 1344 0.4042432087293 1906 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2377 9073351 62.6 µM 0.241510257966208 0.407291770611921 no 1345 0.404579833523835 1818 7337946 YHR072W ERG7 SGTC_1149 3909-7961 23.3 µM 0.241037420111306 0.407479248786661 no 1346 0.404763057158402 1810 735261 SGTC_743 1275-0778 158 µM 0.239738506315676 0.407994371472348 no 1347 0.405266490778488 1968 2849257 YMR203W TOM40 SGTC_1953 st076800 12.1 µM 0.23970434104212 0.408007922873057 no 1348 0.4052797346911 1778 297591 SGTC_2843 9000894 45.46 µM 0.239579671675682 0.408057372979865 no 1349 0.405328062757898 1886 2242070 SGTC_3178 9107506 49.47 µM 0.237649047484 0.408823341581096 no 1350 0.40607665284916 1921 8897194 SGTC_3008 9078912 71.4286 µM 0.237023688718434 0.409071525387606 no 1351 0.406319206441563 1846 16648731 SGTC_3175 9106517 49.47 µM 0.236742782324229 0.409183019535065 no 1352 0.406428171375905 1875 41468073 SGTC_1658 st012944 20 µM 0.236198152422416 0.409399208720196 no 1353 0.406639456558859 1960 24207260 SGTC_2628 lathosterol 100 µM 0.235528290720041 0.409665146070349 no 1354 0.406899361771092 1890 6710616 SGTC_1789 tunicamycin 25 nM 0.235311423109117 0.40975125215457 no 1355 0.40698351483162 2002 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1862 st057513 3.81 µM 0.234915990801158 0.409908267564721 no 1356 0.407136968985403 1882 5393163 SGTC_2760 etidronate 98.04 µM 0.234523994778955 0.410063932779276 no 1357 0.407289103701059 1865 3305 A chelator and antioxidant. SGTC_1976 st070609 63.5 µM 0.232916727104126 0.410702341457112 no 1358 0.407913034636198 1941 682556 SGTC_3324 9138759 60.749 µM 0.231435897934248 0.411290738108702 no 1359 0.40848808976944 1929 45595710 SGTC_9 0092-0002 10.449 µM 0.230048705015665 0.411842110180304 no 1360 0.409026961673158 1938 759368 SGTC_1008 4106-0037 6 µM 0.229504206098167 0.412058581574445 no 1361 0.409238525936862 1897 2905394 SGTC_3340 9146634 11.102 µM 0.228992669329024 0.41226197289445 no 1362 0.409437306894103 1887 4907387 SGTC_2405 ticlatone 3.52 µM 0.227719187190286 0.412768422351791 no 1363 0.409932277538592 1689 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_371 0195-0006 7.36 µM 0.22743144269517 0.412882875232432 no 1364 0.410044136535076 1849 3928593 SGTC_2452 5863136 48.41 µM 0.226378964184802 0.413301570746939 no 1365 0.410453343716972 1886 2184096 SGTC_1939 st074455 53.6 µM 0.226075865448454 0.41342216736889 no 1366 0.410571207627291 2043 1644229 SGTC_1489 4065-0444 182 µM 0.223887516084575 0.414293107328532 no 1367 0.411422414949074 2025 2877968 SGTC_677 0929-0063 136 µM 0.22375561565512 0.414345615822368 no 1368 0.411473733932707 1939 1539583 SGTC_2732 terfenadine 20 µM 0.222766504800092 0.414739421572893 no 1369 0.411858619126122 1970 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1307 1187-1599 12.2 µM 0.219182240369987 0.416167179984004 no 1370 0.413254044636448 1886 1538471 SGTC_3225 9130819 49.47 µM 0.217527112000085 0.416826859761159 no 1371 0.413898790239736 1993 4547121 SGTC_692 k241-0027 77.8 µM 0.21605570102397 0.41741351259884 no 1372 0.414472164802853 2005 3600480 SGTC_905 2-aminofluorene 215 µM 0.215450652121572 0.417654799551319 no 1373 0.414707991221648 1953 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1606 st000094 49.2 µM 0.215064112914826 0.417808963439713 no 1374 0.414858666476966 2063 1242210 SGTC_3010 9080089 71.4286 µM 0.214508008704243 0.418030777291916 no 1375 0.415075461136114 2008 17027233 SGTC_2863 9028737 58.44 µM 0.213928534400828 0.418261940539052 no 1376 0.415301394032973 2072 6460917 SGTC_457 grayanotoxin iii 135 µM 0.213887927621791 0.418278140409933 no 1377 0.415317227377433 1959 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2112 5488546 200 µM 0.213829151651547 0.418301589034085 no 1378 0.415340145473762 1940 600757 SGTC_2192 5915882 198.485 µM 0.21363732615031 0.418378119677107 no 1379 0.415414944631721 1953 2876149 SGTC_1043 0916-0009 19.3 µM 0.213147747626768 0.418573455774709 no 1380 0.415605861508801 2092 3101130 SGTC_2299 7976368 114.88 µM 0.20971032787699 0.419945508808751 no 1381 0.416946882147453 2017 2979718 SGTC_184 1494-0393 24.714 µM 0.209474716693401 0.420039589330518 no 1382 0.417038835358406 1864 3090647 SGTC_957 1187-1561 14.1 µM 0.209408873910933 0.420065881443467 no 1383 0.417064532977628 2039 1538454 SGTC_1970 st070122 35.8 µM 0.209019917661842 0.420221205386472 no 1384 0.417216344990218 2018 102928 SGTC_713 1488-1073 324 µM 0.208873458782389 0.420279694801935 no 1385 0.417273511990252 2055 3312542 SGTC_1675 st018485 24.5 µM 0.208146605548575 0.420569994935036 no 1386 0.417557249005618 1907 3323024 SGTC_2068 5226020 147 µM 0.207567705672553 0.420801234441385 no 1387 0.417783261140453 1900 1810509 SGTC_40 0327-0103 19.753 µM 0.207297313549195 0.42090925098629 no 1388 0.417888836030041 1898 409036 SGTC_1333 1482-0047 286 µM 0.20593204628677 0.421454740235169 no 1389 0.418421996295466 2058 3811116 SGTC_2694 st077685 81.9 µM 0.205127274132609 0.421776355714614 no 1390 0.418736343907847 1898 2838096 SGTC_1154 4088-0362 150 µM 0.204093772124027 0.422189456260615 no 1391 0.41914011051811 2006 6618304 SGTC_3354 9151612 71.43 µM 0.202753107842248 0.42272545998209 no 1392 0.419664005553344 2039 27261949 SGTC_1793 st048256 72.231 µM 0.20047254883123 0.423637566169754 no 1393 0.420555512531577 2028 672022 SGTC_1716 st033144 30.6155 µM 0.199098565361994 0.424187286718646 no 1394 0.421092821719869 2063 674617 SGTC_2892 9047358 58.44 µM 0.198614518433867 0.424380985485424 no 1395 0.421282147901497 1937 6466771 SGTC_215 1287-0124 461.5 µM 0.197978658572167 0.424635462264207 no 1396 0.421530880614442 2071 5560863 SGTC_2182 6325192 200 µM 0.196341417586098 0.425290845021911 no 1397 0.422171472837936 2085 736248 SGTC_486 niguldipine 82 µM 0.195969931601296 0.425439578578546 no 1398 0.422316850376724 1995 1236 A calcium channel blocker. SGTC_551 k048-0028 34.9 µM 0.195728436656366 0.425536272715663 no 1399 0.422411362825028 2032 6836383 SGTC_204 PMA1.184 62.41 µM 0.194880362524469 0.42587587549965 no 1400 0.422743303938917 2012 2252213 YGL008C PMA1 SGTC_2227 7312221 64.1025 µM 0.194811498318519 0.425903453897612 no 1401 0.422770260198423 2031 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_548 1436-0017 110 µM 0.193444051187252 0.426451157268983 no 1402 0.423305609518226 2065 9677137 SGTC_752 1896-0090 130 µM 0.19315027669788 0.42656884126535 no 1403 0.423420639406956 1959 772567 SGTC_1148 3909-7663 27.7 µM 0.192709906797703 0.426745262595599 no 1404 0.423593082192737 2069 4084526 SGTC_3287 9117173 37.0625 µM 0.192287675860951 0.426914430843829 no 1405 0.423758435753708 2102 2789709 SGTC_2848 9016370 25.97 µM 0.19157972045407 0.427198105715808 no 1406 0.424035714493625 2100 7894410 SGTC_1478 0453-0656 35.7 µM 0.190985165806366 0.42743637045448 no 1407 0.424268607605295 2035 5258496 SGTC_2212 7123476 200 µM 0.189861843167037 0.427886608445371 no 1408 0.424708696647613 2046 1085715 SGTC_2499 avocadenofuran 51.48 µM 0.189634896121222 0.427977582319593 no 1409 0.424797620103614 1866 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_348 k064-0012 10.7 µM 0.189414186194328 0.428066059657794 no 1410 0.424884103373229 1953 5066323 SGTC_877 0771-0151 33.1 µM 0.187975519227424 0.42864287530866 no 1411 0.425447920951449 1990 6166523 SGTC_2532 xanthone 78.9 µM 0.187705568267761 0.428751125817335 no 1412 0.425553732507676 2048 7020 An insecticide. SGTC_2859 9028643 45.46 µM 0.187048521114758 0.429014624532724 no 1413 0.425811294942765 2041 17151580 SGTC_2317 5986382 200 µM 0.18629867644484 0.429315376923788 no 1414 0.426105272669848 2038 877883 SGTC_2245 6637752 200 µM 0.185251841649634 0.429735316568435 no 1415 0.426515754476923 2081 681890 SGTC_803 4488-1585 147 µM 0.185225992658093 0.429745686945337 no 1416 0.426525891317068 2060 747204 SGTC_2166 5933061 31.504 µM 0.184232054064265 0.430144482639445 no 1417 0.426915707167376 2043 2877375 SGTC_3207 9114163 49.47 µM 0.183638111888932 0.430382822736983 no 1418 0.427148681284461 2106 849233 SGTC_2750 bromebric acid 70.15 µM 0.183441755399822 0.430461623237778 no 1419 0.427225707809286 1983 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2412 st077135 33.4 µM 0.181291582146779 0.431324697216865 no 1420 0.428069356513161 2048 13258915 SGTC_3191 9110352 49.47 µM 0.181009551374399 0.431437928060307 no 1421 0.42818003947186 2019 17122424 SGTC_2276 7947513 42.08 µM 0.179888454610552 0.431888086101326 no 1422 0.428620069615729 1822 2105100 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.179495295521901 0.432045973672676 no 1423 0.428774405487225 1955 6857784 SGTC_3020 9089140 49.47 µM 0.178448745431534 0.432466307398322 no 1424 0.429185285131775 1968 17217859 SGTC_3230 9131665 49.47 µM 0.176930091807965 0.433076391413216 no 1425 0.429781650823922 2027 15943720 SGTC_1339 1486-1321 22.7 µM 0.176571073959774 0.433220641910485 no 1426 0.429922658338097 1968 3469382 SGTC_1087 pterostilbene 9.05 µM 0.176325145751089 0.433319459031985 no 1427 0.430019254031197 2079 5281727 Similar to reservatol, lowers cholesterol. SGTC_1109 tnp00067 928.257 nM 0.175442943102957 0.433673973675438 no 1428 0.430365800052087 1958 676295 SGTC_2194 5927483 104.545 µM 0.173689096265571 0.434378918261201 no 1429 0.431054903596672 2067 760979 SGTC_1440 4100-1550 40 µM 0.173174892221484 0.434585638093778 no 1430 0.431256979278028 2073 742806 SGTC_2743 auranofin 4.32 µM 0.172691576825929 0.43477995640792 no 1431 0.431446932518476 2061 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2213 7173844 200 µM 0.171732945343002 0.435165423463427 no 1432 0.431823741970359 2024 892728 SGTC_317 4495-0002 170 µM 0.171545306441233 0.435240880550049 no 1433 0.4318975044983 1972 15991618 SGTC_772 k072-0172 35.3 µM 0.170516940105868 0.435654469478564 no 1434 0.432301806586395 1883 5861980 SGTC_744 1594-0068 283 µM 0.169244873914449 0.436166167084691 no 1435 0.432802017291498 1991 668392 SGTC_2722 naftopidil 47.16 µM 0.168613013111238 0.436420377329322 no 1436 0.433050522070926 2081 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1767 st044992 70.3 µM 0.168153105462242 0.436605423899826 no 1437 0.433231415982799 1991 9600693 SGTC_90 0870-0863 4.608 µM 0.166122405979175 0.437422653213195 no 1438 0.434030310861239 1976 1738164 SGTC_630 4356-0227 183 µM 0.165571398325608 0.437644445478176 no 1439 0.434247128701758 2076 779312 SGTC_970 1315-0089 19.5 µM 0.164407253777522 0.438113102690161 no 1440 0.434705276793284 2098 6811083 YLR033W RSC58 SGTC_2669 eugenol 100 µM 0.162756695044124 0.438777727459858 no 1441 0.435355002939773 2136 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2151 5563267 85.4165 µM 0.162000872381804 0.439082129704502 no 1442 0.435652583441949 2001 5310824 SGTC_286 k060-0067 22.9 µM 0.161102327562843 0.43944405915489 no 1443 0.436006403531121 2033 5985051 SGTC_216 k038-0035 28.382 µM 0.160965983414524 0.439498982340838 no 1444 0.436060096263676 2091 4444231 YPR107C YTH1 SGTC_2953 9074162 66.49 µM 0.160822141265991 0.439556927190603 no 1445 0.436116743008457 2150 16451992 SGTC_322 k048-0136 19.3 µM 0.159746366629882 0.439990329320714 no 1446 0.436540437294452 2049 6823282 SGTC_1995 st072814 61.1 µM 0.159626170203307 0.440038757867842 no 1447 0.436587781238162 1964 5769371 SGTC_3101 9120531 49.47 µM 0.158968251296697 0.440303856971901 no 1448 0.436846943751626 2127 24824904 SGTC_2340 7987427 183.45 µM 0.158321198515913 0.440564603827589 no 1449 0.437101852401277 2042 2239331 SGTC_1783 st039459 87.517 µM 0.158244984087245 0.440595318125513 no 1450 0.437131879056524 2135 729761 SGTC_3198 9112019 49.47 µM 0.157917615024444 0.440727251418332 no 1451 0.437260858724674 2055 45595555 SGTC_1128 3448-9350 235 µM 0.157242066186603 0.44099952572903 no 1452 0.437527038306 1963 619386 SGTC_2113 5491891 107.031 µM 0.157004191900943 0.441095405617136 no 1453 0.437620772208952 1992 789979 SGTC_1908 st060353 56.5 µM 0.15681785993507 0.441170512775943 no 1454 0.437694198405712 2153 4227716 SGTC_1647 st011722 22.4 µM 0.155946981632783 0.441521576610086 no 1455 0.438037406156233 2086 2854783 SGTC_2196 6573537 42.6665 µM 0.155281742151286 0.441789775384442 no 1456 0.438299604336844 2141 2903087 SGTC_1191 1487-1166 10.6 µM 0.154926515002204 0.441933000141139 no 1457 0.438439625035292 2091 3955771 SGTC_1837 st055472 66.5 µM 0.154922087844211 0.441934785183909 no 1458 0.438441370146946 2082 676091 SGTC_1285 0929-0069 65.5 µM 0.154049845848091 0.442286498608831 no 1459 0.438785216662733 2020 1206237 SGTC_3133 9127736 49.47 µM 0.152603502698832 0.44286980651128 no 1460 0.439355481301163 2169 27243420 SGTC_698 k064-0052 127 µM 0.152519589956461 0.442903652200733 no 1461 0.439388570318719 2133 5088751 SGTC_1831 st055328 12 µM 0.151314705601782 0.443389680730595 no 1462 0.439863734727504 2130 1103068 SGTC_444 curcumin 90.4 µM 0.149297242520249 0.444203679162555 no 1463 0.440659545519409 2092 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2933 9026794 32.47 µM 0.149295181772544 0.444204510746244 no 1464 0.440660358527407 2090 17586027 SGTC_2990 9074105 71.4286 µM 0.148301793154177 0.444605406287902 no 1465 0.441052300138346 2135 6502001 SGTC_3237 9133362 49.47 µM 0.148271583536706 0.444617598681556 no 1466 0.441064220253579 2145 43845137 SGTC_2849 9019321 12.99 µM 0.147319955795144 0.445001695852472 no 1467 0.441439740942121 2061 16489627 SGTC_3113 9123498 49.47 µM 0.147229823290867 0.445038077928619 no 1468 0.441475310756848 2172 8897275 SGTC_2153 5569715 200 µM 0.145415432358371 0.445770556709398 no 1469 0.442191440454735 2149 2054701 SGTC_845 0330-0138 4.51 µM 0.144163843868243 0.446275937354795 no 1470 0.442685545530658 2157 9039800 SGTC_2893 9048488 25.97 µM 0.14352462391188 0.446534082588424 no 1471 0.442937932747541 2005 6467338 SGTC_1882 5615643 20 µM 0.141311591359279 0.44742797715574 no 1472 0.443811896461722 2184 2253075 SGTC_1207 2099-0101 141 µM 0.141104771299997 0.44751153023499 no 1473 0.443893587207625 2147 5837381 SGTC_2710 st078562 53.7235 µM 0.141085831059688 0.447519182004819 no 1474 0.443901068430767 2130 17250908 SGTC_223 busulfan 5 mM 0.140748055312003 0.447655645128275 no 1475 0.444034490142466 2113 2478 A DNA alkylator. SGTC_3172 9105863 49.47 µM 0.140736483401972 0.447660320348763 no 1476 0.444039061169374 2151 2348785 SGTC_818 4072-2707 53.5 µM 0.139306727270985 0.448238018435618 no 1477 0.444603887062133 2125 882871 SGTC_1507 4075-3230 155 µM 0.139251434764509 0.448260361783845 no 1478 0.444625732662128 2176 659771 SGTC_2330 7979373 200 µM 0.138883371212926 0.448409098090389 no 1479 0.4447711557306 1977 1863007 SGTC_2993 9054257 71.4286 µM 0.138103163465997 0.44872440786504 no 1480 0.445079442825714 2137 6470217 YGL055W OLE1 SGTC_1354 1498-1681 81 µM 0.136418121422472 0.449405503707306 no 1481 0.445745374385954 2059 5754243 SGTC_2657 nystatin 74.44 µM 0.135718421594916 0.449688367069196 no 1482 0.446021942071442 2125 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1774 st048371 48.465 µM 0.135106840133295 0.449935628303595 no 1483 0.446263701062093 2098 4242727 SGTC_414 piperonyl butoxide 100 µM 0.134328750577061 0.450250236530675 no 1484 0.446571309795165 2030 5794 A potent inhibitor of cytochrome P450. SGTC_2764 methyldopa 94.69 µM 0.133466115461797 0.450599065958488 no 1485 0.446912380215455 2151 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1572 epiandrosterone 68.9 µM 0.132250946566177 0.451090516470172 no 1486 0.447392902721721 2084 441302 A steroid. SGTC_931 2812-0076 566 µM 0.131555873262879 0.451371658586266 no 1487 0.447667795054714 2073 3450959 SGTC_2765 myclobutanil 7.74 µM 0.131145514504309 0.451537651288724 no 1488 0.447830098346351 2073 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_234 nsc-17383 10.7 µM 0.130123838832125 0.451950962282805 no 1489 0.448234224903377 2160 408974 SGTC_963 1269-2853 151 µM 0.130103468131053 0.451959203623478 no 1490 0.44824228313662 2047 3668223 SGTC_3308 9128332 17.569 µM 0.128920508556413 0.452437827004866 no 1491 0.448710274304363 2160 17332805 YDL196W YDL196W SGTC_1482 3346-2049 8.48 µM 0.128891442800349 0.452449587831974 no 1492 0.448721773922222 2162 3826804 SGTC_835 0312-0010 67.2 µM 0.128861951187096 0.452461521015588 no 1493 0.448733442070869 2097 1626196 SGTC_2346 9031566 143.75 µM 0.128681961172421 0.452534351257638 no 1494 0.448804654810687 2145 4771086 SGTC_3292 9120825 59.784 µM 0.126320849092006 0.45348988659023 no 1495 0.449738976632338 2202 24824900 SGTC_2011 4012611 177 µM 0.125754695077889 0.453719047747456 no 1496 0.449963052534767 2087 2049887 SGTC_750 4073-0104 132 µM 0.124972355138332 0.454035739443018 no 1497 0.450272718066892 2184 22330957 SGTC_1928 4'-methoxychalcone 40.3 µM 0.12259792816732 0.454997087091922 no 1498 0.451212747575426 2225 641818 SGTC_1922 5578187 25 µM 0.121552291068092 0.455420524028012 no 1499 0.451626799711601 2173 1350412 SGTC_1175 0741-0056 27.6 µM 0.120775612283297 0.455735077511131 no 1500 0.451934383628637 2173 765927 SGTC_2008 4012253 172 µM 0.120453939689585 0.455865362458904 no 1501 0.452061782354116 2120 603940 SGTC_660 4031-1742 102 µM 0.118664565564731 0.456590187206011 no 1502 0.452770555360216 2099 6738706 SGTC_119 0121-0043 24.815 µM 0.118281662770904 0.456745309122092 no 1503 0.452922243192843 2198 1092378 SGTC_1760 st045453 10.4495 µM 0.117565264157367 0.457035554842705 no 1504 0.453206064604723 2196 3323419 YIL048W NEO1 SGTC_3239 9133757 49.47 µM 0.117242712489918 0.457166242712328 no 1505 0.45333386031134 2139 17036923 SGTC_510 ag-490 170 µM 0.116863293781268 0.457319977260714 no 1506 0.453484193054572 2227 5328779 SGTC_596 1155-0152 116 µM 0.116497403263549 0.457468236446587 no 1507 0.453629171991045 2153 280313 SGTC_2491 paeonol 100 µM 0.116299003006803 0.457548630895643 no 1508 0.453707787868578 2087 11092 Increases levels of cortical cytochrome oxidase. SGTC_1141 3253-0389 52.6 µM 0.115927542362812 0.457699156406494 no 1509 0.45385498360414 2187 5402031 SGTC_801 0866-0028 10.1 µM 0.112702761391912 0.459006174185399 no 1510 0.455133105963377 2153 6849771 SGTC_64 000l-0018 272.079 µM 0.112663678316132 0.45902201747339 no 1511 0.455148599179234 2028 6811119 SGTC_438 sphingosine 6.67 µM 0.112346860283061 0.459150449871323 no 1512 0.455274193913152 2049 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2382 9035899 200 µM 0.111340887404842 0.459558281589171 no 1513 0.455673016745618 2149 6462679 SGTC_2717 st081029 62.2815 µM 0.110989154571723 0.459700887749356 no 1514 0.455812473496177 2217 5292846 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.110537726072516 0.459883922002039 no 1515 0.455991466046397 2114 641818 YHR062C RPP1 SGTC_433 pimozide 108 µM 0.110332054433977 0.459967315559194 no 1516 0.456073018339033 2131 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1122 capsaicin 818.572 nM 0.109657734174737 0.460240744127528 no 1517 0.456340410719621 2133 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2924 9010168 62.78 µM 0.108395967625912 0.460752425346401 no 1518 0.456840799829261 2125 2993929 SGTC_2558 carylophyllene oxide 100 µM 0.108095977407501 0.460874089268007 no 1519 0.456959779510975 2238 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1416 3966-0321 25.3 µM 0.108004189381916 0.460911315517849 no 1520 0.456996184502864 2145 582530 YLR208W SEC13 SGTC_2665 lovastatin 100 µM 0.10798992705496 0.460917099886413 no 1521 0.457001841263298 2134 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_3061 glucosamine 200 µM 0.107974318044395 0.460923430438605 no 1522 0.457008032158799 2206 91431 and experimental redox chemotherapeutic SGTC_2457 5731572 11.68 µM 0.107306117001057 0.461194442248256 no 1523 0.457273065949922 2231 2865357 SGTC_959 1222-0044 107 µM 0.10726551687003 0.461210909603452 no 1524 0.457289170110142 2248 6083612 SGTC_180 1486-1293 102.781 µM 0.10657268413863 0.461491931798787 no 1525 0.457563995019382 2235 4140536 SGTC_446 go6976 132 µM 0.10626500751284 0.461616735715232 no 1526 0.457686047154769 2225 3501 A protein kinase C inhibitor. SGTC_2409 alverine citrate 63.97 µM 0.10608648550209 0.461689151939443 no 1527 0.457756866820313 2164 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2969 9091408 28.7 µM 0.105270873641696 0.462020015395013 no 1528 0.458080436999703 1975 4286311 SGTC_3149 9097855 49.47 µM 0.10469512826526 0.462253589761494 no 1529 0.45830886389956 2212 25236625 YMR079W SEC14 SGTC_851 0394-0702 453 µM 0.104450549860244 0.462352816814239 no 1530 0.458405904519917 2230 762646 SGTC_775 4577-0580 57.3 µM 0.104183167012014 0.462461298458837 no 1531 0.45851199602532 2174 2006902 SGTC_326 k292-0812 17.5 µM 0.103859239499495 0.462592724948761 no 1532 0.458640527141088 2212 3579357 SGTC_3075 9116269 49.47 µM 0.103727430056805 0.462646204911545 no 1533 0.458692829015052 2139 17015205 YNL244C SUI1 SGTC_1329 1447-1697 50.6 µM 0.10194426405675 0.463369767227843 no 1534 0.459400457661247 2151 2840515 SGTC_2540 epiandrosterone 100 µM 0.101637178832526 0.463494386712495 no 1535 0.459522333900783 2258 441302 A steroid. SGTC_816 0325-0417 81.3 µM 0.101587406484091 0.463514585366218 no 1536 0.459542087950419 2126 68101 SGTC_2025 5147754 141 µM 0.101409435500931 0.463586810460116 no 1537 0.459612723321214 2210 315777 YLR208W SEC13 SGTC_2449 5812982 45.77 µM 0.100545713684886 0.46393734746445 no 1538 0.459955546206898 2225 776185 SGTC_1501 4491-0275 38.4 µM 0.0997016511511597 0.464279932901761 no 1539 0.460290594823493 2245 5104718 SGTC_3050 9093513 49.47 µM 0.0992927103902745 0.464445922026877 no 1540 0.460452933041126 2204 25236664 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.0990612690238034 0.464539866861217 no 1541 0.460544811811227 2085 2374 Ca(2+)-ATPase inhibitor. SGTC_1637 st007924 17.4 µM 0.0975111214244514 0.465169141122181 no 1542 0.461160251350368 2219 683336 SGTC_331 k048-0133 24.5 µM 0.0971580735309947 0.465312471292848 no 1543 0.461300431471188 2231 6813582 SGTC_918 glabranin 770.725 nM 0.0970709313983554 0.465347849896449 no 1544 0.461335032601423 2152 124049 Also referred to as licorice root. SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.096530879590057 0.465567110197323 no 1545 0.461549475034129 2209 5282309 SGTC_779 1360-0071 233 µM 0.096161759956682 0.46571697828536 no 1546 0.461696050578339 2249 7566 SGTC_63 0099-0242 26.702 µM 0.0950167191273163 0.466181912817563 no 1547 0.462150773529747 2262 3898502 YLR359W ADE13 SGTC_1421 4029-0249 71.4 µM 0.0946249655654031 0.466340991799898 no 1548 0.462306359577122 2256 2894095 SGTC_703 3875-0075 71.8 µM 0.0928102704818414 0.467077952992498 no 1549 0.46302714578336 2168 2850814 SGTC_277 nystatin 15.5 µM 0.0926586836409663 0.467139518680857 no 1550 0.463087360711182 2245 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2465 5809242 33.21 µM 0.0909577994729284 0.467830371675998 no 1551 0.463763061571882 2231 2731748 SGTC_1519 esterone 74 µM 0.0903387835745544 0.46808182329699 no 1552 0.464009000648909 2055 698 A steroid. SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.0893665407140724 0.468476785582353 no 1553 0.464395306844177 2214 17037758 SGTC_2304 7443016 91.4 µM 0.0884681389680176 0.468841778371249 no 1554 0.464752303221333 2231 939854 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.0877648845775277 0.469127507126377 no 1555 0.465031774038703 2243 6312947 SGTC_1391 3442-0225 151 µM 0.085718225552982 0.469959144435507 no 1556 0.465845206778667 2197 5227075 SGTC_2818 7996756 12.99 µM 0.0851417660359274 0.47019340621097 no 1557 0.46607434317107 2231 2241621 SGTC_2833 9001315 45.46 µM 0.085084190483654 0.47021680434756 no 1558 0.466097229446279 2096 2989378 SGTC_186 3455-3465 67.277 µM 0.0843796252538133 0.470503141012388 no 1559 0.466377303099408 2258 755278 SGTC_2845 9003024 42.97 µM 0.0839161410828881 0.47069151019679 no 1560 0.4665615530491 2233 2990173 SGTC_2989 9073649 71.4286 µM 0.0823421392086002 0.471331264562722 no 1561 0.467187322965008 2282 21367202 SGTC_1302 1159-0335 255 µM 0.0812475165049166 0.471776218584923 no 1562 0.46762255584333 2213 649284 SGTC_1017 4239-0030 168 µM 0.0810393775721581 0.47186082914252 no 1563 0.467705318349779 2086 1149593 SGTC_2981 9013952 38.96 µM 0.0804923037331935 0.472083226174808 no 1564 0.467922858553073 2044 2996344 SGTC_531 3788-1495 174 µM 0.0799218757192241 0.472315126439563 no 1565 0.468149695586547 2182 2896655 SGTC_847 0342-0274 5.54 µM 0.0789382894551791 0.472715012942622 no 1566 0.468540853833978 2250 18097 SGTC_2316 5844804 197.44 µM 0.0786045377778126 0.472850709182497 no 1567 0.46867358904244 2261 776813 SGTC_1827 berberine 7.24 µM 0.0784884257024272 0.472897918589774 no 1568 0.468719768385728 2183 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1361 1608-0041 5.61 µM 0.077529502800431 0.473287816578859 no 1569 0.469101161030036 2226 X1361 SGTC_911 3456-4043 236 µM 0.0774585699987721 0.47331665887252 no 1570 0.469129374281485 2215 914281 SGTC_960 1222-0186 7.7 µM 0.076976662078195 0.473512613234879 no 1571 0.469321055416577 2207 3126296 SGTC_2603 homopterocarpin 100 µM 0.0769546242328864 0.473521574461224 no 1572 0.469329821243244 2197 101795 A weak amylase inhibitor. SGTC_2745 rifampicin 24.3 µM 0.0767229858872707 0.473615766132907 no 1573 0.469421959170519 2268 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2950 9072895 21.46 µM 0.0766858193378517 0.473630879396014 no 1574 0.469436742923876 2184 17332245 SGTC_1661 st013063 9.66 µM 0.0761410229828876 0.473852417640612 no 1575 0.469653451614741 2262 721395 SGTC_2369 9071472 200 µM 0.0753788763346382 0.474162353662397 no 1576 0.469956632814776 2227 17296037 SGTC_1619 st003326 88.7 µM 0.0753422448751543 0.47417725067756 no 1577 0.469971205214062 2286 2849032 SGTC_379 3970-0972 5.9 µM 0.0748861831199947 0.474362721567238 no 1578 0.470152634979936 2180 2898042 YBL034C STU1 SGTC_1701 st028638 40.4 µM 0.0738893837398725 0.474768118562525 no 1579 0.470549201652873 2268 3490878 SGTC_1325 1431-0015 227 µM 0.0730289549686422 0.475118074835468 no 1580 0.470891538144682 2185 1103340 SGTC_2403 6032726 181.2 µM 0.0724701518474227 0.475345363282742 no 1581 0.471113879184397 2218 2881040 SGTC_2435 5706476 10.6 µM 0.0707384012821952 0.476049788823246 no 1582 0.471802978785545 2270 5725375 SGTC_2279 7948423 32.93 µM 0.0704314229408266 0.476174666518834 no 1583 0.471925140725813 2294 1247112 SGTC_1009 4106-0057 9.87 µM 0.0673554878990293 0.477426073100841 no 1584 0.473149352092045 2308 2928005 SGTC_3346 9158254 43.5805 µM 0.067151262304715 0.477509167805351 no 1585 0.473230642269778 2219 17639500 SGTC_2401 5128683 200 µM 0.0669711261001614 0.477582461902084 no 1586 0.473302344806043 2235 708373 SGTC_74 000s-0487 160.283 µM 0.0642183519003154 0.478702607781606 no 1587 0.474398182426078 2300 677548 SGTC_2415 st077333 57.7 µM 0.0641080126953022 0.478747510055898 no 1588 0.474442110882152 2320 2766255 SGTC_2881 9058953 51.95 µM 0.0640781200972205 0.478759674823305 no 1589 0.474454011834191 2278 17122249 SGTC_53 0973-0023 39.979 µM 0.0639715190239198 0.478803056200587 no 1590 0.474496452434466 2316 674768 SGTC_2662 daunorubicin 22.37 µM 0.0633078781615694 0.479073130916241 no 1591 0.474760671241951 2269 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1232 0279-0259 161 µM 0.0627208721487468 0.47931202639169 no 1592 0.474994388271892 2233 1560000 SGTC_1792 st045773 43.6 µM 0.0624157172783102 0.479436219062447 no 1593 0.47511588939262 2249 2919270 SGTC_884 0851-0618 334 µM 0.0597129170428513 0.480536297044208 no 1594 0.476192141890801 2289 9642473 SGTC_1988 st071872 53.4 µM 0.0586939460247776 0.480951071615283 no 1595 0.476597940699545 2317 16414116 SGTC_160 3453-0671 289.699 µM 0.0585743636382824 0.480999749270289 no 1596 0.476645565233359 2279 5322268 SGTC_2912 7964298 10.93 µM 0.0584251627961848 0.481060483922151 no 1597 0.476704985994922 2244 2975850 SGTC_994 3910-0338 138 µM 0.0583721908175672 0.481082047141387 no 1598 0.47672608275193 2269 3479481 SGTC_2803 7707263 71.43 µM 0.0574611445397936 0.481452913912427 no 1599 0.477088928554233 2262 2199229 SGTC_2044 5102272 200 µM 0.0573727191589224 0.481488910787185 no 1600 0.477124147076916 2252 592666 SGTC_913 3487-1245 167 µM 0.0572472664470258 0.481539981287599 no 1601 0.47717411334495 2260 4016153 SGTC_1150 3909-7983 10.9 µM 0.0564577156272637 0.481861406172798 no 1602 0.47748858990396 2253 23965914 SGTC_296 1222-0039 74.9 µM 0.0555223957268633 0.482242188660198 no 1603 0.477861144128898 2254 5984176 SGTC_3269 9137823 49.47 µM 0.0555056009725674 0.48224902620077 no 1604 0.477867833950171 2249 17682936 SGTC_381 3461-2219 42.7 µM 0.0552952000182042 0.482334685833305 no 1605 0.477951643074148 2314 2883159 SGTC_1745 st081495 74 µM 0.0552104072260763 0.482369207387602 no 1606 0.477985418907968 2282 13842402 YBL026W LSM2 SGTC_284 0988-0104 32.6 µM 0.0551193314525003 0.48240628706936 no 1607 0.478021697641691 2286 4666532 SGTC_2936 9038235 15.59 µM 0.0545912476622952 0.482621288824189 no 1608 0.478232055857799 2310 4749415 SGTC_2368 9071271 200 µM 0.0526831597747586 0.483398181159211 no 1609 0.478992178471677 2265 27209959 SGTC_1167 k781-0610 148 µM 0.05204042410855 0.483659890159877 no 1610 0.47924824162742 2253 4525169 SGTC_2515 chrysin 20.77 µM 0.0514260315921762 0.48391006498423 no 1611 0.479493021001054 2293 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1254 0550-0035 264 µM 0.0505783633885033 0.484255237841235 no 1612 0.479830752134187 2289 15121435 SGTC_2361 9034121 116 µM 0.0499750363527631 0.484500921495962 no 1613 0.480071140781149 2261 6496917 SGTC_121 0557-0495 61.343 µM 0.049005116715429 0.484895899351062 no 1614 0.48045760914579 2312 3104427 SGTC_1136 pergolide 1.05886 µM 0.0489356907677101 0.484924172072423 no 1615 0.480485272901559 2230 47811 A dopamine receptor agonist. SGTC_1714 st033236 13.627 µM 0.0487174932332785 0.485013030381247 no 1616 0.480572217422119 2299 2916566 SGTC_250 brefeldin a 552.239 µM 0.0477686619994665 0.485399439031209 no 1617 0.480950306067261 2315 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_3352 9151559 45.5865 µM 0.0475805392877937 0.485476053076648 no 1618 0.481025270929713 2276 17159339 SGTC_1552 6-methylflavone 10.6 µM 0.0467017714930974 0.485833943320148 no 1619 0.481375459220447 2327 689013 SGTC_1370 2001-0092 44.6 µM 0.0459022141548415 0.486159583939938 no 1620 0.48169409469943 2303 790957 SGTC_1158 4092-0494 91.8 µM 0.0456909368816412 0.486245633680967 no 1621 0.481778293793639 2270 1148199 SGTC_837 0091-0265 12.5 µM 0.0455159747390691 0.486316893354508 no 1622 0.481848021046963 2284 759367 SGTC_3057 9095946 49.47 µM 0.044894324497122 0.486570086463773 no 1623 0.482095770340218 2329 24540043 SGTC_2505 galangin 7.89 µM 0.0442482597812606 0.486833229125935 no 1624 0.482353256978223 2311 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.0430612729389807 0.487316704650251 no 1625 0.482826345182069 2285 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2987 9018338 71.43 µM 0.0424347128728875 0.487571918458579 no 1626 0.483076078195371 2338 5055682 SGTC_535 2293-4129 48.2 µM 0.0423250557855063 0.487616585098122 no 1627 0.483119785775621 2339 396118 YIL048W NEO1 SGTC_2504 purpurogallin 52.29 µM 0.0422211196337849 0.487658921571395 no 1628 0.483161213268691 2215 5281571 An antioxidant. SGTC_1546 5-methoxyflavanone 78.7 µM 0.0420389368250535 0.487733130711608 no 1629 0.483233829220698 2334 147795 SGTC_2794 7785382 27.27 µM 0.0418435951981237 0.487812700349561 no 1630 0.483311690742629 2348 2205081 SGTC_1447 4239-0816 81.9 µM 0.0412547753562166 0.488052550673388 no 1631 0.483546393194753 2288 1341554 SGTC_2417 cerulenin 830 nM 0.0412002173241131 0.488074774603897 no 1632 0.483568140210865 2342 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2882 9058044 58.44 µM 0.0405123772533686 0.48835496583128 no 1633 0.483842319760988 2288 18076804 SGTC_1385 3091-4834 14.1 µM 0.0399876789004056 0.488568705252608 no 1634 0.484051474625195 2298 4072814 SGTC_644 1498-1197 63.3 µM 0.0394704075959898 0.488779422429541 no 1635 0.484257673220828 2304 6741615 SGTC_3210 9128157 49.47 µM 0.0394656762364914 0.488781349824762 no 1636 0.484259559290613 2164 17590849 SGTC_2462 5162487 171.77 µM 0.0387699651680899 0.489064761721105 no 1637 0.484536895573428 2332 2259986 SGTC_507 nimesulide 162 µM 0.0387539618436774 0.48907128106269 no 1638 0.484543275181714 2331 4495 A COX2 inhibitor. SGTC_1013 4112-3890 241 µM 0.0386503882060393 0.489113474361673 no 1639 0.484584564150788 2284 705171 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.0375115510043562 0.489577415969642 no 1640 0.485038565130059 2280 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2248 tofa 1.1 µM 0.0373485419458089 0.489643824070162 no 1641 0.48510355079685 2324 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2952 9073731 13.78 µM 0.037192998469664 0.489707191042082 no 1642 0.485165560581687 2323 16457353 SGTC_270 tamoxifen 5.46 µM 0.0359338855949912 0.49022015139272 no 1643 0.4856675382546 2346 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_961 1252-1571 372 µM 0.0354089862105081 0.490433999296418 no 1644 0.485876809623445 2340 6813498 SGTC_573 3702-0553 84.7 µM 0.0344408680078596 0.490828425002499 no 1645 0.486262797415637 2333 1222756 SGTC_2769 toremifene 3.73 µM 0.0324242614730988 0.491650048747346 no 1646 0.487066857399978 2312 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2908 7930301 100 µM 0.0321905758112429 0.491745261392207 no 1647 0.48716003584951 2354 2223178 SGTC_2759 disulfiram 3.38 µM 0.0321784429332799 0.491750204812371 no 1648 0.487164873661257 2335 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1811 st050069 61.5 µM 0.0316871864722127 0.491950363415618 no 1649 0.487360756735223 2352 3877702 SGTC_2103 5378138 10 µM 0.0308864306225765 0.492276629446226 no 1650 0.487680055777915 2354 244142 SGTC_2518 prenyletin 46.28 µM 0.0306768175543755 0.49236203664514 no 1651 0.487763639685584 2348 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2335 9018011 154.17 µM 0.0304351419456713 0.492460508214709 no 1652 0.487860009304691 2337 6458208 SGTC_2273 7815444 169.05 µM 0.0299500771330897 0.492658150944639 no 1653 0.488053433982818 2346 2824616 SGTC_2860 9025725 38.96 µM 0.0271390033294698 0.493803574731676 no 1654 0.489174433024587 2345 40546248 SGTC_1417 3966-0327 90.4 µM 0.026740856435539 0.493965811364481 no 1655 0.48933321302481 2342 651118 SGTC_302 1094-0063 18.9 µM 0.0258721369469798 0.494319800034629 no 1656 0.489679662050107 2346 5440289 SGTC_3128 9127691 49.47 µM 0.0249320203272513 0.494702886873051 no 1657 0.490054593319781 2318 41316314 SGTC_888 0916-0002 6.97 µM 0.0247569717495012 0.494774217729175 no 1658 0.490124406049237 2353 2802138 YIL048W NEO1 SGTC_891 0929-0073 133 µM 0.0242766025466122 0.49496996508117 no 1659 0.490315988046609 2343 5603632 SGTC_2835 9006588 71.43 µM 0.024225374295693 0.494990840335313 no 1660 0.490336419153093 2286 2345538 SGTC_2234 tolnaftate 200 µM 0.0221326129698083 0.495843641108381 no 1661 0.491171085727505 2360 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1616 st002734 56.1 µM 0.0206430093553975 0.496450666760351 no 1662 0.491765215630937 2327 4026101 SGTC_2129 girgensonine 121.053 µM 0.0191826209485585 0.497045794963167 no 1663 0.492347710763487 2350 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1353 1498-1206 8.11 µM 0.0188710756679871 0.49717275481186 no 1664 0.492471976852164 2361 6756808 SGTC_252 miconazole 1.30953 nM 0.0174256487787936 0.497761793690299 no 1665 0.49304852374687 2371 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2477 5967686 25.23 µM 0.0171744959366478 0.497864143771731 no 1666 0.493148704241424 2365 776118 SGTC_711 k292-0785 179 µM 0.0171347521699233 0.497880340208153 no 1667 0.493164557377541 2372 4146315 SGTC_344 k064-0035 6.43 µM 0.0169622558373894 0.497950636199414 no 1668 0.493233363457696 2362 5088750 SGTC_1761 st044296 37 µM 0.0169297397513836 0.497963887215856 no 1669 0.49324633363676 2378 1826700 SGTC_2397 5161689 200 µM 0.0164701003039515 0.498151200580256 no 1670 0.49342967767652 2356 2259942 SGTC_3285 9112818 20.8695 µM 0.0150170585417582 0.498743350111568 no 1671 0.494009285584321 2379 17017947 YPR165W RHO1 SGTC_257 daunorubicin 18.5 µM 0.0146924326054832 0.498875643427465 no 1672 0.494138778307103 2365 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_760 0568-0725 82.9 µM 0.0144170411139907 0.498987872553862 no 1673 0.494248631980037 2374 3916171 SGTC_1626 st003712 1.76 µM 0.0143720821499338 0.499006194497622 no 1674 0.494266566153574 2365 24207035 SGTC_3068 9116768 49.47 µM 0.0134919670191745 0.499364864611132 no 1675 0.494617647205225 2362 41904888 SGTC_1978 st071761 42 µM 0.0122707366975617 0.499862548944251 no 1676 0.49510480716564 2360 5147680 SGTC_162 k030-0015 37.8 µM 0.0122413638695827 0.499874519170549 no 1677 0.495116524348559 2382 1809920 YMR134W ERG29 SGTC_2999 9069765 71.4286 µM 0.0120116752617167 0.499968123528486 no 1678 0.495208150108217 2379 2097066 SGTC_1702 st027038 51 µM 0.0118552367715482 0.499968123528486 no 1679 0.495270555592505 2367 5521182 SGTC_1213 1315-0166 115 µM 0.0116112146722837 0.49986867788294 no 1680 0.495367899624174 2358 768401 SGTC_393 acivicin 6.25 µM 0.0110917880647908 0.49965699744116 no 1681 0.495575107506659 2382 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2856 9022925 19.48 µM 0.0104581631330693 0.49939877821914 no 1682 0.495827872604159 2380 4944862 SGTC_771 0250-0039 27.3 µM 0.00935841112351358 0.498950600321921 no 1683 0.496266588620804 2386 3005115 SGTC_416 estradiol valerate 100 µM 0.00897519239759305 0.498794428884353 no 1684 0.496419464349052 2378 13791 A steroid. SGTC_329 k048-0121 21.3 µM 0.00884345094900739 0.49874074091419 no 1685 0.496472019497086 2369 6832902 SGTC_1392 3455-1037 33.9 µM 0.00683998424336452 0.497924280970592 no 1686 0.497271262365565 2385 981132 SGTC_721 1187-1332 279 µM 0.00662699765716236 0.497837484363789 no 1687 0.49735622979357 2386 25730 SGTC_3215 9129942 49.47 µM 0.00656167300502042 0.497810863185812 no 1688 0.497382289992634 2391 17682944 SGTC_1924 st058459 75.1 µM 0.00586596406914848 0.49752734770206 no 1689 0.497659832338189 2395 688683 SGTC_1956 st077085 54 µM 0.0052993403939117 0.497296437993005 no 1690 0.497885878953781 2397 24208685 SGTC_1 0258-0098 57.368 µM 0.00337509832045061 0.496512280703821 no 1691 0.498653533135793 2330 6790032 YDR047W HEM12 SGTC_513 4245-1575 41.7 µM 0.00337323234691599 0.496511520297879 no 1692 0.498654277547293 2393 719745 SGTC_126 0417-1624 672.48 µM 0.00325951476973322 0.496465179085133 no 1693 0.498699644047352 2397 41912 YDL195W SEC31 SGTC_992 3909-8734 162 µM 0 0.495136912281794 no 1694 0.5 2404 4288319 SGTC_3186 9110464 49.47 µM -0.00101511926876832 0.494723256972623 no 1695 0.49959502607359 2408 17018021 SGTC_1235 benzylparaben 21.5 µM -0.00101612309397138 0.494722847922316 no 1696 0.499594625605481 2408 7180 SGTC_49 0717-0965 32.132 µM -0.00216202537508558 0.494255906128765 no 1697 0.499137477338534 2421 5889349 YGL099W LSG1 SGTC_85 0868-0259 160.055 µM -0.00349146159345457 0.49371418630436 no 1698 0.49860711117993 2420 83173 SGTC_3272 9137413 49.47 µM -0.0040591380074969 0.493482872499906 no 1699 0.498380642673744 2410 17614870 SGTC_1445 4239-0156 97.7 µM -0.00441259577872734 0.493338848485254 no 1700 0.498239634690226 2417 4008346 SGTC_301 4119-0100 24.5 µM -0.00510391379106151 0.49305715853428 no 1701 0.497963841833524 2418 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_667 1498-1044 59 µM -0.00545732109028097 0.492913157705986 no 1702 0.497822854686118 2417 6739982 SGTC_511 blebbistatin 171 µM -0.00546136238141636 0.492911511029765 no 1703 0.497821242468242 2421 3476986 A myosin inhibitor. SGTC_2247 cerulenin 830 nM -0.00682528696340425 0.492355769438528 no 1704 0.497277125595085 2424 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1629 st005085 44.9 µM -0.00719774445226765 0.492204011295493 no 1705 0.497128540208358 2416 24207091 SGTC_1055 3448-0672 86 µM -0.00733484416035518 0.492148150177535 no 1706 0.497073846782113 2444 748378 SGTC_1180 1193-0155 285 µM -0.00736748765915494 0.492134849644249 no 1707 0.497060824262133 2427 2921347 SGTC_1225 1216-0074 20.6 µM -0.00790669786060719 0.491915150719974 no 1708 0.496845716790539 2437 4241466 SGTC_863 0466-0191 129 µM -0.00799426041744204 0.491879473954911 no 1709 0.496810785488472 2413 765160 YPR165W RHO1 SGTC_1780 st038448 24.544 µM -0.00805672792901062 0.491854022034138 no 1710 0.496785865359507 2446 728868 YDL195W SEC31 SGTC_1211 1056-0033 32.3 µM -0.00881435361595668 0.491545335780635 no 1711 0.49648362720107 2424 6741922 SGTC_175 3793-3120 23.7 µM -0.00905947884201657 0.491445463278446 no 1712 0.49638584028977 2429 5322297 SGTC_2000 st075254 36.4 µM -0.00921971354553113 0.491380178403127 no 1713 0.496321918561637 2426 17234175 SGTC_2885 9057732 51.95 µM -0.00931036118545609 0.491343245682734 no 1714 0.496285756937571 2426 6471414 SGTC_1471 k673-0312 37 µM -0.0102924883023826 0.490943100804201 no 1715 0.495893963741478 2425 24099884 SGTC_1387 3342-1166 1.8 µM -0.0116486627505238 0.490390574096347 no 1716 0.495352961012744 2450 3418228 SGTC_2690 usnic acid 100 µM -0.0130735542217203 0.489810070880599 no 1717 0.494784555035006 2444 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1807 st050092 58.9 µM -0.0131169253512132 0.489792401740727 no 1718 0.494767253941209 2427 5008496 SGTC_1104 tacrolimus 29.8 µM -0.0139163887849891 0.489466708722666 no 1719 0.494448343318152 2435 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_3310 9130229 44.1445 µM -0.0143731287718979 0.489280640780917 no 1720 0.494266148654945 2476 7761258 SGTC_2389 9091542 195.52 µM -0.0157227310560489 0.488730850024461 no 1721 0.493727796238687 2461 3626624 YOL127W RPL25 SGTC_3001 9076041 71.4286 µM -0.0159598567881854 0.48863425372176 no 1722 0.493633208627552 2437 16004211 SGTC_1398 3558-0053 112 µM -0.0169305852654785 0.48823882165179 no 1723 0.493245996373777 2443 4532369 SGTC_3126 9127922 49.47 µM -0.0170503770305166 0.488190024551036 no 1724 0.493198213271314 2473 45595682 SGTC_1952 st077036 64.1 µM -0.0182369686036669 0.487706676880016 no 1725 0.492724905426888 2437 2937007 SGTC_2887 9044784 58.44 µM -0.0185862540960818 0.487564401905882 no 1726 0.492585584292799 2446 6465546 SGTC_3214 9129694 49.47 µM -0.018819066409786 0.487469571001088 no 1727 0.492492721860246 2435 17158655 SGTC_2677 mitomycin C 100 µM -0.0198821019140767 0.487036576275677 no 1728 0.492068711463718 2439 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2644 guaiazulene 100 µM -0.0202905960195036 0.486870192837485 no 1729 0.491905778766745 2449 3515 A coloring agent. SGTC_2496 diffractaic acid 79.83 µM -0.0209420062829354 0.486604872134888 no 1730 0.491645958897098 2439 94870 An apoptosis inducer which activates caspases. SGTC_60 0986-0278 202 µM -0.0211539714436828 0.486518539573994 no 1731 0.491561415761795 2435 3110598 SGTC_1516 st013856 110 µM -0.0213441001264659 0.486441101460524 no 1732 0.491485582513734 2541 5281404 A mutagen and neurotoxin. SGTC_2854 9024559 71.43 µM -0.0251109180228795 0.484907011442606 no 1733 0.48998324580313 2461 3163529 SGTC_2962 9082311 13.18 µM -0.0256780970364721 0.484676038536142 no 1734 0.489757047064478 2468 16459453 SGTC_3042 9091578 49.47 µM -0.0258651608393392 0.484599861470601 no 1735 0.489682444183358 2439 25236497 SGTC_351 caspofungin 25 nM -0.0258911882725853 0.484589262492404 no 1736 0.489672064215996 2468 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_599 1935-0052 86.5 µM -0.0263035539988012 0.484421339003462 no 1737 0.48950761010613 2457 9557311 SGTC_3060 1327-0027 12.5 µM -0.0263586669559014 0.484398896124701 no 1738 0.489485630838083 2451 16000455 YPR107C YTH1 SGTC_2175 5807670 165.306 µM -0.0273643985135326 0.483989354879655 no 1739 0.489084546739512 2450 241186 SGTC_61 0978-8327 98.565 µM -0.029851127181932 0.4829768142002 no 1740 0.48809289165953 2452 6150059 YHR072W ERG7 SGTC_3236 9132701 49.47 µM -0.0300614957178278 0.482891161750084 no 1741 0.488009004404093 2468 24282524 SGTC_1466 k213-0079 57.5 µM -0.0305062429329616 0.482710083621266 no 1742 0.487831657279649 2451 3657981 SGTC_3327 9140648 26.9345 µM -0.0311089437676139 0.48246470062324 no 1743 0.487591328513928 2463 8029710 SGTC_3159 9100096 49.47 µM -0.0318859027774944 0.482148380145066 no 1744 0.487281520439044 2446 25236875 SGTC_1829 berberine 14.4 µM -0.0324803504335015 0.48190637242398 no 1745 0.487044492921913 2523 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_472 calcifediol 10 µM -0.0329872091494686 0.481700028613586 no 1746 0.486842393855704 2513 5283731 A vitamin D metabolite. SGTC_1955 wogonin 32.4 µM -0.033493079716749 0.481494091969773 no 1747 0.486640692161768 2616 5281703 A flavanone. SGTC_1885 st057546 99.9 µM -0.0338825147698391 0.481335558833714 no 1748 0.48648541818731 2579 702008 SGTC_726 3448-4391 34.2 µM -0.0342486551084447 0.48118651131617 no 1749 0.486339434055744 2504 1356692 SGTC_1270 0831-1170 17.3 µM -0.0346924490176014 0.481005856299839 no 1750 0.486162491057794 2464 6764716 SGTC_997 3996-0078 137 µM -0.0351321300085465 0.480826879374116 no 1751 0.485987190588652 2499 735687 SGTC_1256 0570-0116 285 µM -0.0354354804624744 0.480703399525988 no 1752 0.485866246575139 2484 410638 SGTC_2411 st077133 39.94 µM -0.0354713644742951 0.480688792937493 no 1753 0.4858519399198 2671 1403142 YNL221C POP1 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.035981660655292 0.480481079671285 no 1754 0.485648491080711 2453 756377 SGTC_3282 9108498 15.4605 µM -0.0360272427414336 0.480462525989724 no 1755 0.485630318242051 2515 16459645 SGTC_3203 9113543 49.47 µM -0.0367624339713899 0.480163280445181 no 1756 0.485337213568053 2559 17018012 SGTC_1393 3470-5649 58.2 µM -0.0371413887920748 0.480009038480826 no 1757 0.485186135648042 2523 4108395 SGTC_2978 9011784 42.97 µM -0.0388265031958933 0.479323200793501 no 1758 0.484514357133665 2571 2994934 SGTC_1633 st005664 67.9 µM -0.0391064989006294 0.479209249061519 no 1759 0.484402739780491 2476 2063822 SGTC_2441 5730946 39.09 µM -0.0404020074020098 0.478682029535082 no 1760 0.483886314941105 2527 1774275 SGTC_629 3448-6466 76.7 µM -0.0411731470447922 0.478368224561155 no 1761 0.483578930533902 2482 573744 SGTC_3267 9137951 49.47 µM -0.042605301326376 0.477785464238197 no 1762 0.483008084741015 2477 16643986 SGTC_2114 5491910 81.25 µM -0.0448127012419759 0.476887340862145 no 1763 0.482128300568518 2535 2849228 SGTC_2183 6420625 130.508 µM -0.0453540167123457 0.476667113934806 no 1764 0.481912566295377 2480 2897619 SGTC_3312 9133330 71.43 µM -0.0467055958449518 0.476117273377612 no 1765 0.48137393518784 2588 17617324 SGTC_3300 9124615 50.48 µM -0.0472498215000047 0.475895887848724 no 1766 0.481157060010186 2557 24824903 SGTC_2376 9072922 81.32 µM -0.0474978743599988 0.47579498490183 no 1767 0.481058212220202 2598 17087968 SGTC_464 bw-b 70c 158 µM -0.0475579268995371 0.475770556961842 no 1768 0.481034281766675 2593 5353454 SGTC_1432 4049-0298 68.4 µM -0.047710130256734 0.475708644676432 no 1769 0.480973630260529 2512 741646 SGTC_2202 7226349 200 µM -0.0477286540289643 0.475701109737611 no 1770 0.480966248753744 2483 844334 SGTC_2243 6634756 200 µM -0.0489810746295061 0.475191681281617 no 1771 0.480467189046042 2541 885676 SGTC_755 1995-0008 37.3 µM -0.051340467731583 0.474232096949443 no 1772 0.479527111010116 2485 689533 SGTC_2837 9008476 45.46 µM -0.0523052208523457 0.473839766762657 no 1773 0.479142746687458 2575 2992805 SGTC_2566 crystal violet carbinol 226 nM -0.0528372343632896 0.47362342694641 no 1774 0.478930797095296 2620 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2242 6630449 61.2675 µM -0.0529893202695075 0.473561583633844 no 1775 0.478870208474969 2671 691249 YDR170C SEC7 SGTC_1892 st058411 7.36 µM -0.0537302897883636 0.473260289317281 no 1776 0.47857502494485 2495 3934738 SGTC_1131 3454-3128 32.3 µM -0.0557978467349337 0.472419657143882 no 1777 0.477751425165017 2678 710982 SGTC_164 4100-3994 89.624 µM -0.0558339987767994 0.472404959443341 no 1778 0.47773702503568 2492 4615967 SGTC_2826 7992541 19.48 µM -0.0590789151305426 0.471085886256681 no 1779 0.476444626295535 2491 2985066 SGTC_1284 0929-0043 16 µM -0.0611488910589795 0.470244596442545 no 1780 0.475620316268414 2571 1239883 SGTC_2123 5259487 200 µM -0.0611644900686008 0.470238257115644 no 1781 0.475614104790712 2548 2173474 SGTC_2716 st080858 38.6235 µM -0.0616606423629629 0.470036628285292 no 1782 0.475416541571655 2527 5296050 SGTC_3223 9129970 49.47 µM -0.0620947798828729 0.46986020762686 no 1783 0.475243677014117 2532 17248386 SGTC_1301 naphtanilide LB 4.81 µM -0.0630947560761534 0.469453869418893 no 1784 0.474845525012978 2555 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_3343 9148379 18.9835 µM -0.0636240382615195 0.469238809571934 no 1785 0.474634795376132 2549 1955036 SGTC_584 0986-0246 15.4 µM -0.0647649564099684 0.468775258198789 no 1786 0.474180571790287 2525 53315 YDR232W HEM1 SGTC_1670 st016595 4.04 µM -0.0649888652566431 0.468684289703528 no 1787 0.474091432875563 2512 597879 SGTC_1338 1486-1223 76 µM -0.0652862500291022 0.468563472328496 no 1788 0.473973044937486 2589 3444526 SGTC_745 0469-0705 296 µM -0.0668654905460207 0.467921929094606 no 1789 0.473344393042144 2554 3486736 SGTC_1324 1418-0026 34.4 µM -0.067101878948741 0.46782590690995 no 1790 0.473250299042019 2621 1372513 SGTC_370 0180-0345 38.7 µM -0.0672345088606178 0.467772032777241 no 1791 0.473197506585318 2499 3989527 SGTC_3319 9138450 16.7555 µM -0.068612719548286 0.467212240143503 no 1792 0.472648946996709 2558 2029690 SGTC_254 nsc-64875 3.808 µM -0.0714320535075411 0.46606730464203 no 1793 0.471526949874399 2659 56993 SGTC_2133 5320837 200 µM -0.0726205883174186 0.46558472256404 no 1794 0.471054021434081 2606 2841355 SGTC_17 0960-0276 49.807 µM -0.0727384748046269 0.46553685973277 no 1795 0.471007115579551 2534 6821114 SGTC_424 splitomicin 100 mM -0.0733171799478177 0.465301908184356 no 1796 0.470776860435242 2633 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.0733970080447424 0.465269499302392 no 1797 0.470745099205065 2605 5377381 SGTC_2571 chrysanthemic acid 100 µM -0.0733993611996857 0.465268543964049 no 1798 0.470744162957386 2588 2743 An insecticide. SGTC_2688 kanamycin b 96.69 µM -0.073873158974828 0.46507619472262 no 1799 0.470555656756172 2569 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1134 3477-0009 42.5 µM -0.0739409291373741 0.465048682512801 no 1800 0.470528694112004 2628 3973534 SGTC_1499 4480-0877 67.3 µM -0.0741642952784207 0.4649580052044 no 1801 0.470439827910633 2532 2861909 SGTC_916 4466-0038 42 nM -0.0748625253836718 0.464674564749275 no 1802 0.470162046632547 2550 5722064 YGL116W CDC20 SGTC_609 0986-0026 86.3 µM -0.0754137348556928 0.464450818698239 no 1803 0.469942765747349 2539 2848610 SGTC_2071 5230951 39.92 µM -0.0767393875051397 0.463912758094882 no 1804 0.469415435105768 2547 1799272 SGTC_2840 9008771 71.43 µM -0.0791149976382164 0.462948702769447 no 1805 0.468470577257544 2673 2992978 SGTC_3213 9129884 49.47 µM -0.0796564905342071 0.462728987736302 no 1806 0.468255232481398 2604 17190742 SGTC_1035 k081-0041 55.2 µM -0.080107201520135 0.46254611685058 no 1807 0.468075997586357 2534 731709 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.0808909146102942 0.46222815299888 no 1808 0.467764352689309 2672 165506 SGTC_949 1165-0505 146 µM -0.0826811974370651 0.46150189996591 no 1809 0.46705251797275 2556 6244267 SGTC_2336 9001819 198.65 µM -0.0835467012124422 0.461150842246237 no 1810 0.466708422482016 2632 2989602 SGTC_780 0109-0199 192 µM -0.0836623358249224 0.46110394187952 no 1811 0.466662451887804 2595 610414 SGTC_1476 4112-3294 3.34 µM -0.0840560093881556 0.460944275455991 no 1812 0.466505950116815 2667 704369 SGTC_1896 st058441 89 µM -0.0847896107141532 0.460646757688777 no 1813 0.466214326622406 2581 688759 SGTC_3325 9138760 55.175 µM -0.0862462963731237 0.460056052861934 no 1814 0.465635314301851 2589 43844959 SGTC_221 trifluoperazine 10.304 µM -0.0863054121671175 0.460032082497341 no 1815 0.465611818122298 2576 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1452 4194-0072 190 µM -0.0864767578129606 0.45996260581793 no 1816 0.465543715712895 2663 1343545 SGTC_2723 salbutamol 83.58 µM -0.0867421225705646 0.459855008986009 no 1817 0.465438246805836 2606 9884233 β2-adrenoceptor agonist SGTC_231 b-estradiol 524 µM -0.0874537428789613 0.459566484487124 no 1818 0.46515542616596 2551 450 A steroid. SGTC_1424 4048-1941 275 µM -0.0897083914166381 0.45865248475728 no 1819 0.464259473722936 2667 X1424 SGTC_401 neomycin 50 µM -0.090724973547743 0.458240449242519 no 1820 0.463855563219638 2604 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_308 4092-1169 104 µM -0.0915341168196619 0.457912523760479 no 1821 0.463534099354853 2585 2268590 YDL196W YDL196W SGTC_908 3448-7491 47.7 µM -0.0915562141680323 0.457903568660032 no 1822 0.463525320650522 2577 1203031 SGTC_361 000s-0510 1.45 µM -0.0916352600157247 0.457871534968586 no 1823 0.463493917927435 2623 660 SGTC_3076 9116187 49.47 µM -0.0917278289267249 0.457834021341761 no 1824 0.463457143155509 2637 27241210 SGTC_2083 5306046 65.942 µM -0.0921971713299359 0.457643825736683 no 1825 0.463270692713018 2597 539837 SGTC_1268 0828-0275 2.46 µM -0.0929725141914406 0.457329648236475 no 1826 0.462962698560066 2656 745337 SGTC_3129 9127257 49.47 µM -0.0943533577752536 0.456770181306702 no 1827 0.462414232774677 2594 837894 SGTC_1736 st036774 51 µM -0.0959704768297733 0.456115093263699 no 1828 0.461772010190951 2785 1272247 SGTC_1309 pyrazolanthrone 13.4 µM -0.0960227774709635 0.456093908478241 no 1829 0.461751241171616 2620 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_3248 9135562 49.47 µM -0.0960524600254942 0.456081885381932 no 1830 0.461739454028885 2600 17650701 SGTC_1762 st045503 25.4615 µM -0.097040291223923 0.45568178145029 no 1831 0.461347198825679 2633 4645554 SGTC_135 0933-0004 26.348 µM -0.098496095199239 0.455092215279841 no 1832 0.460769186231954 2662 21230617 YGL099W LSG1 SGTC_3226 9131256 49.47 µM -0.0986271015267055 0.45503916564744 no 1833 0.460717175509672 2556 17178073 SGTC_528 3492-0019 172 µM -0.0988586781914929 0.454945393078187 no 1834 0.460625239078792 2564 2869262 SGTC_2479 5617353 43.85 µM -0.100887438839753 0.454123992920908 no 1835 0.459819907291527 2675 2731746 SGTC_455 paf C-16 10 µM -0.103329679779894 0.453135444290785 no 1836 0.45885066031533 2589 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1068 loratadine 26.9 µM -0.104589709507971 0.452625533788333 no 1837 0.458350690270803 2646 3957 A H1 histamine antagonist. SGTC_646 4092-0839 27.3 µM -0.105958706683112 0.452071614764718 no 1838 0.457807557489968 2681 877796 SGTC_588 3970-1144 52.9 µM -0.106021420989441 0.452046241739783 no 1839 0.457782678240221 2719 1888707 SGTC_2569 tetrandrine 100 µM -0.107027240211829 0.451639333092589 no 1840 0.457383684653368 2656 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3257 9139206 32.98 µM -0.108535079187875 0.451029425414585 no 1841 0.45678562784481 2690 4910041 SGTC_1929 genistein trimethyl ether 50.5 µM -0.110441104559391 0.45025862041846 no 1842 0.456029777884242 2606 136420 SGTC_2828 7998861 71.43 µM -0.111497962130602 0.44983130325456 no 1843 0.455610740754635 2630 2988188 SGTC_2064 5220758 200 µM -0.111624650727389 0.449780083395307 no 1844 0.455560512857851 2733 788518 SGTC_1923 st058458 19.1 µM -0.111805613754121 0.449706921981123 no 1845 0.455488768151828 2769 3534982 SGTC_1231 0242-0792 125 µM -0.111951701249189 0.449647861617926 no 1846 0.455430851278014 2598 3707635 SGTC_1739 st037196 92.5 µM -0.112012220475247 0.449623395186023 no 1847 0.455406858506753 2647 612214 SGTC_2906 7926292 26.41 µM -0.112070498466648 0.449599835011068 no 1848 0.455383754423881 2708 2966319 SGTC_3234 9132280 49.47 µM -0.112112639764008 0.449582798564471 no 1849 0.455367047764561 2672 17612295 SGTC_1688 st021091 57.6 µM -0.112455824763277 0.449444062755291 no 1850 0.455230997114166 2586 3656366 SGTC_684 1140-0066 328 µM -0.113839446261077 0.44888478342418 no 1851 0.45468253412068 2656 6813534 SGTC_981 1488-1094 54.9 µM -0.115002801272623 0.448414617458035 no 1852 0.454221450841675 2601 3449522 SGTC_729 4092-0585 94.1 µM -0.115427488421127 0.448242999609143 no 1853 0.454053145982772 2594 2169061 SGTC_582 0987-0078 156 µM -0.116154805587468 0.447949110223463 no 1854 0.453764927071523 2615 1625765 SGTC_154 3389-1638 511.116 µM -0.116751278137377 0.447708112957118 no 1855 0.453528577009756 2720 5238686 SGTC_324 1315-0088 19.6 µM -0.117461860601921 0.44742103620999 no 1856 0.453247032802204 2635 6787421 SGTC_876 0720-0963 56.8 µM -0.11763570398522 0.447350807320614 no 1857 0.453178156828452 2783 765861 SGTC_2293 7624732 200 µM -0.117917100366784 0.447237132893504 no 1858 0.453066671822176 2606 894453 SGTC_2034 5197015 53.07 µM -0.119454951957034 0.446615970733509 no 1859 0.452457463773164 2744 780676 SGTC_1638 st008370 60.6 µM -0.119800532218111 0.446476403461582 no 1860 0.452320580165736 2596 24207134 SGTC_423 5-fluorouracil 457 µM -0.119996849049274 0.446397121200603 no 1861 0.452242822008883 2598 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1490 4089-0339 670 nM -0.12024001522378 0.44629892187292 no 1862 0.452146510068674 2629 742542 SGTC_3099 9120367 49.47 µM -0.120590530363512 0.446157376933243 no 1863 0.452007684888774 2607 24824940 SGTC_2144 5628481 200 µM -0.121564598963146 0.445764064865335 no 1864 0.451621925715428 2628 2818399 SGTC_2587 piperic acid 92.2 µM -0.122889837240623 0.445229042317081 no 1865 0.451097166666615 2682 5370536 SGTC_2581 avocatin a 64 µM -0.123910552624796 0.44481702908935 no 1866 0.450693048778578 2684 6710728 A skin care supplement. SGTC_3190 9110366 49.47 µM -0.123912274854949 0.444816333958931 no 1867 0.450692366962611 2656 17123768 SGTC_2598 perillyl alcohol 100 µM -0.12719433419925 0.443491932518543 no 1868 0.449393294807046 2760 10819 An apoptosis inducer. SGTC_1794 st048918 76.9 µM -0.128020761910297 0.443158545010817 no 1869 0.449066271303327 2593 672303 SGTC_875 0709-0210 25.7 µM -0.128245225773537 0.443068001442605 no 1870 0.44897745527247 2607 6251364 SGTC_633 0437-0093 97.7 µM -0.133719903468748 0.440860573907056 no 1871 0.446812032910513 2629 2831118 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.134151465951688 0.440686642147744 no 1872 0.446641401731474 2890 6710655 SGTC_1313 1220-0047 237 µM -0.135233578665063 0.440250570825477 no 1873 0.44621359950273 2691 3528706 SGTC_3073 9114972 49.47 µM -0.135347086060224 0.440204833643668 no 1874 0.446168729130323 2703 41905075 SGTC_1203 3992-3522 103 µM -0.135730615770745 0.440050298358158 no 1875 0.446017121900749 2941 5322312 SGTC_1843 st055809 45.5 µM -0.136124585432703 0.439891566021109 no 1876 0.445861396031921 2787 16413835 SGTC_2902 5787006 60.46 µM -0.136169281367399 0.43987355841638 no 1877 0.445843729428868 2659 591003 SGTC_2171 5739187 198.077 µM -0.136312588403605 0.439815822092429 no 1878 0.44578708633311 2626 2262761 SGTC_1980 st071811 45.7 µM -0.136642707164158 0.439682826909579 no 1879 0.445656608825249 2799 4974850 SGTC_1848 st056003 16.4 µM -0.137644660612515 0.439279210944884 no 1880 0.445260628687587 2629 146492 SGTC_687 k029-0044 34.9 µM -0.138297679253118 0.439016190007652 no 1881 0.445002579787427 2722 5829338 SGTC_2246 7293507 91.5585 µM -0.138299391800402 0.439015500268216 no 1882 0.445001903082445 2837 887656 SGTC_525 k781-2675 26.7 µM -0.139781275683984 0.438418731629357 no 1883 0.444416403938181 2647 3651118 YDL195W SEC31 SGTC_3238 9133470 49.47 µM -0.141192890360609 0.437850391232383 no 1884 0.443858781240826 2772 3534688 SGTC_256 clotrimazole 625 nM -0.143608246626535 0.436878225104799 no 1885 0.442904914148981 2651 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1876 myriocin 605 nM -0.144823655143346 0.436389174360973 no 1886 0.442425052508491 2747 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1804 st050076 49.1 µM -0.145684259321104 0.436042946977617 no 1887 0.442085324013179 2758 3895976 SGTC_1830 st055982 50.3 µM -0.146702102546755 0.435633524442731 no 1888 0.441683579485057 2642 455313 An antimicrobial agent. SGTC_1695 st026914 34.495 µM -0.148843202548969 0.434772502960002 no 1889 0.440838679806073 2650 3289191 SGTC_2309 7664088 163.95 µM -0.150313163297947 0.434181552056098 no 1890 0.440258774085023 2723 704922 SGTC_2004 4023728 41.89 µM -0.151716121445988 0.433617674546464 no 1891 0.439705420647514 2743 360084 YDR527W RBA50 SGTC_2089 5281248 129.67 µM -0.152516616422619 0.433295999731706 no 1892 0.439389742869666 2677 2737878 SGTC_323 4013-0906 34.3 µM -0.153134861365581 0.433047591391093 no 1893 0.439145962346624 2793 2910086 SGTC_37 0566-0070 1.56 µM -0.153220474524348 0.433013194449934 no 1894 0.439112205989367 2795 1626686 SGTC_3152 9099253 49.47 µM -0.154198676039366 0.432620216890234 no 1895 0.43872654303686 2776 25236131 SGTC_161 4065-0411 162.148 µM -0.156481277932854 0.431703476167974 no 1896 0.437826837747561 2808 1906281 YLR208W SEC13 SGTC_2359 9039622 200 µM -0.156549133928505 0.431676229382622 no 1897 0.43780009667423 2696 6463596 SGTC_547 1120-0019 610 nM -0.156855294874338 0.431553298061625 no 1898 0.437679446576579 2660 3676939 SGTC_1569 carminic acid 40.6 µM -0.159298792963808 0.430572410660804 no 1899 0.436716735845909 2778 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_590 k048-0076 22.4 µM -0.159943642169198 0.430313621602891 no 1900 0.436462734775116 2792 6832814 SGTC_575 k072-0246 11.9 µM -0.161259688957591 0.429785562416633 no 1901 0.435944435610331 2687 6796779 SGTC_172 1112-0046 2.638 µM -0.161348014261388 0.42975012668306 no 1902 0.435909654353913 2752 2802135 YIL048W NEO1 SGTC_947 3447-0010 211 µM -0.162020292586655 0.429480430065693 no 1903 0.435644936913376 2658 748350 SGTC_1679 SEC14.276 6.7 µM -0.163166530495872 0.429020671940766 no 1904 0.43519365890319 2854 1005053 YMR079W SEC14 SGTC_696 1560-0013 611 µM -0.163423689796622 0.428917538075879 no 1905 0.435092425926766 2882 1650269 SGTC_985 1493-0307 8.71 µM -0.163551353368968 0.428866340339169 no 1906 0.435042171640407 2774 3278274 SGTC_1303 1160-0052 261 µM -0.164266614092586 0.428579516930648 no 1907 0.434760631370179 2711 3562476 SGTC_1177 0983-0204 23.6 µM -0.164563672488801 0.428460405988217 no 1908 0.434643713230007 2810 766818 SGTC_2278 7948257 134.34 µM -0.165142872561143 0.42822818398158 no 1909 0.434415764412658 2806 1247028 SGTC_3041 9091929 49.47 µM -0.165414945313667 0.428119108866662 no 1910 0.434308695528129 2826 25236887 SGTC_2618 avocadyne 43.43 µM -0.165647171050502 0.428026012932497 no 1911 0.434217311464821 2722 3015189 SGTC_2516 gossypol 71.55 µM -0.166854848543454 0.427541937221156 no 1912 0.433742130326397 2838 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3349 9149703 23.001 µM -0.166987435405455 0.427488798802931 no 1913 0.433689967603179 2674 4910494 SGTC_2187 6125751 200 µM -0.16778819340201 0.427167897464722 no 1914 0.433374955558431 2747 874498 SGTC_2678 equilin 100 µM -0.168998534488341 0.426682948475137 no 1915 0.432898897064365 2791 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2058 5236698 133 µM -0.169364181188163 0.426536466081519 no 1916 0.432755097867293 2740 766665 SGTC_246 cycloheximide 667 µM -0.169536742009205 0.426467339693274 no 1917 0.432687237342268 2695 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1738 st035555 74 µM -0.169816911277486 0.426355111093688 no 1918 0.432577063412037 2806 5331140 SGTC_1238 0333-0287 48.8 µM -0.169915299802696 0.426315700596529 no 1919 0.432538374292831 2716 7226 SGTC_1839 st053978 48 µM -0.170141393016039 0.426225139511891 no 1920 0.432449470570904 2708 3788398 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.171636061978406 0.42562655159152 no 1921 0.431861827389538 2680 2346 DNA damaging agent; causes G2/M arrest. SGTC_1568 digitonin 820 nM -0.171911952611962 0.425516081070408 no 1922 0.431753374829697 2782 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1245 0418-0076 17.2 µM -0.172115713708579 0.425434495991742 no 1923 0.431673279680069 2889 6790114 SGTC_833 3852-0053 558 µM -0.172387700209252 0.42532559872642 no 1924 0.431566370619303 2871 3123681 SGTC_253 dyclonine 31.25 µM -0.172459085334552 0.425297018674446 no 1925 0.431538312274871 2686 3180 An oral anasthetic. SGTC_3188 9110789 49.47 µM -0.173051494468418 0.425059854397668 no 1926 0.431305475712543 2855 849217 SGTC_2337 9009472 200 µM -0.173476615666811 0.424889678656679 no 1927 0.431138403597792 2851 5742383 SGTC_978 1416-0512 87.4 µM -0.173887652726512 0.4247251540956 no 1928 0.430976878247497 2759 6814003 SGTC_1019 4262-0212 3.4 µM -0.173985874047544 0.424685841284402 no 1929 0.430938281894972 2756 4677213 SGTC_2905 7799065 20.05 µM -0.174160381573347 0.424615996979476 no 1930 0.430869710284527 2840 1296806 SGTC_144 4161-2749 112.381 µM -0.174377261626394 0.42452919693568 no 1931 0.430784491566608 2705 797501 YMR168C CEP3 SGTC_2446 5162541 200 µM -0.174415342732701 0.424513956438672 no 1932 0.430769528683228 2697 1549321 SGTC_3263 9137018 49.47 µM -0.175507239836694 0.424077014748302 no 1933 0.430340541253713 2741 43844957 SGTC_1064 honokiol 6.76 µM -0.176702838619933 0.423598682060178 no 1934 0.429870905534176 2792 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_571 k831-0106 44.2 µM -0.176986680261318 0.42348513979091 no 1935 0.429759426012609 2749 4783639 SGTC_141 0443-0274 32.331 µM -0.177906097772868 0.423117398272413 no 1936 0.429398360956798 2833 1627241 SGTC_36 0335-0881 14.2 µM -0.178168575037926 0.423012426917413 no 1937 0.429295294160435 2709 23828853 SGTC_2696 st077691 74.316 µM -0.179296794708683 0.422561285413502 no 1938 0.428852331762555 2869 757133 SGTC_2135 5326629 150.42 µM -0.180020221119957 0.42227206210015 no 1939 0.428568346687338 2772 5020077 SGTC_2036 5160441 105 µM -0.181062043388143 0.421855618923632 no 1940 0.428159438556174 2770 134534 YIL048W NEO1 SGTC_3077 9117319 49.47 µM -0.181217000462296 0.421793686045264 no 1941 0.428098625540464 2703 17154678 SGTC_2705 st078069 42.8 µM -0.181637479226628 0.421625639833015 no 1942 0.427933616953436 2804 1530061 SGTC_1845 st056753 3.01 µM -0.181757792859142 0.421577558578358 no 1943 0.427886404562013 2673 5375839 SGTC_466 geldanamycin 89.2 µM -0.182353195269391 0.421339633564442 no 1944 0.427652777323415 2778 5288382 HSP90 inhibitor. SGTC_1727 st034309 9.9045 µM -0.183527449095564 0.420870481626251 no 1945 0.427192091631668 3031 870305 SGTC_2463 5473429 200 µM -0.185509407493345 0.420078881079805 no 1946 0.426414751108472 2800 5399405 SGTC_2345 9052315 157.45 µM -0.185561035387592 0.42005826503852 no 1947 0.426394506026062 2819 6469265 SGTC_1426 4048-4480 71.7 µM -0.187480559683454 0.419291917104871 no 1948 0.425641932285136 2832 14224343 SGTC_2884 9058502 51.95 µM -0.188434556047273 0.418911158732737 no 1949 0.425268006527631 2837 6471554 SGTC_2700 st077718 96.8 µM -0.188715081347513 0.418799210100933 no 1950 0.425158065385578 2800 904970 SGTC_2706 st078239 82.5 µM -0.189489341966748 0.41849026171587 no 1951 0.424854653829811 2737 15434492 SGTC_675 1309-0189 238 µM -0.189827162327707 0.418355479106447 no 1952 0.424722285208844 2778 4246530 SGTC_3260 9137109 49.47 µM -0.189927296044283 0.418315529881328 no 1953 0.424683051305907 2854 17478346 SGTC_2985 9022375 71.43 µM -0.190153495843533 0.418225288588287 no 1954 0.424594425554361 2943 4939335 SGTC_2360 9040895 200 µM -0.190888919288008 0.417931924807443 no 1955 0.424306310836115 2801 4914414 SGTC_153 4077-0274 519.67 µM -0.191103746599277 0.417846237818556 no 1956 0.424222156186978 2973 3121976 SGTC_530 4358-1714 28 µM -0.191752006612777 0.417587693566693 no 1957 0.423968233203794 2845 1564641 SGTC_2942 9052777 62.25 µM -0.192116257459101 0.417442435749885 no 1958 0.423825570251037 2779 6469503 SGTC_1033 k072-0102 21.3 µM -0.192300587372147 0.417368932015483 no 1959 0.423753379164408 2895 5965931 SGTC_3301 9125354 19.7965 µM -0.193642326566891 0.416833984792916 no 1960 0.423227976808698 2730 41905162 SGTC_3256 9138902 49.47 µM -0.194406113036972 0.416529534215254 no 1961 0.422928951861561 2721 17228773 SGTC_2069 5228469 200 µM -0.19496480362917 0.416306867969176 no 1962 0.422710250739553 2884 2835210 SGTC_201 4262-0159 12.803 µM -0.196193825148936 0.415817135818974 no 1963 0.422229230478711 2855 1341029 SGTC_1982 st072467 71.9 µM -0.196329614022766 0.415763035595194 no 1964 0.422176091888197 2704 3163533 SGTC_94 0334-0113 514.748 µM -0.197046797020483 0.415477326167972 no 1965 0.421895458441937 2766 6795178 SGTC_1926 methyl fluorone black 53.6 µM -0.197254849094649 0.415394451298542 no 1966 0.42181405515547 2747 72721 Reacts with homocysteine. SGTC_3262 9137218 49.47 µM -0.19832246546268 0.414969239328847 no 1967 0.421396387934356 2701 17650664 SGTC_894 0960-0238 55.9 µM -0.198387853927824 0.414943199537097 no 1968 0.421370809874404 2745 6741907 YDL195W SEC31 SGTC_2484 5809818 12.04 µM -0.199046436529355 0.414680951599167 no 1969 0.421113210091936 2807 2870548 SGTC_287 k060-0039 29.6 µM -0.199566096787032 0.414474049442613 no 1970 0.420909972599348 2894 5861974 SGTC_56 0957-0365 83.25 µM -0.199996191759667 0.414302825548837 no 1971 0.420741779746023 2747 6752360 SGTC_92 0063-0024 660.874 µM -0.200108823485891 0.414257988740181 no 1972 0.420697736394981 2695 3594437 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.201334236822576 0.413770244493868 no 1973 0.42021861676092 2755 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2772 vinpocetine 57.06 µM -0.201865900723967 0.413558670684167 no 1974 0.420010780266299 2948 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2601 securinine 100 µM -0.201922553259901 0.413536127481944 no 1975 0.419988635136944 2782 442872 A GABA receptor antagonist. SGTC_805 3852-0218 479 µM -0.203969473036898 0.412721807998374 no 1976 0.419188677196653 2760 6615355 SGTC_2592 piperlongumine 83.33 µM -0.204917356215762 0.412344841675344 no 1977 0.418818347329373 2852 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_52 0329-0193 875 nM -0.20509547769641 0.412274013057033 no 1978 0.418748764805426 2982 3739292 SGTC_1458 k015-0034 6.33 µM -0.205104693069714 0.412270348713386 no 1979 0.418745164921706 2822 3598957 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.205589171293341 0.412077714587316 no 1980 0.418555918447764 2824 140250 A respiratory chain inhibitor. SGTC_108 0509-0257 621.132 µM -0.208844995925595 0.410783712905734 no 1981 0.417284622042931 2875 536624 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.209352290787332 0.410582179606956 no 1982 0.417086616950228 2752 6708784 An antioxidant flavonoid SGTC_413 propylparaben 100 µM -0.209804682342886 0.410402477684477 no 1983 0.416910059209499 2762 7175 A pharmaceutical preservative. SGTC_1346 1488-2224 62.4 µM -0.210360794616377 0.410181600918806 no 1984 0.416693044685846 2814 3722427 SGTC_2035 5154463 94.595 µM -0.210484404495906 0.410132509394046 no 1985 0.416644811219421 2896 2769623 SGTC_839 0122-0028 230 µM -0.210487578704905 0.410131248779053 no 1986 0.416643572636702 2782 759448 SGTC_648 0375-0473 33.3 µM -0.210643357583655 0.41006938342393 no 1987 0.416582788422802 2796 1713139 SGTC_2775 cyproheptadine 69.59 µM -0.210847307671419 0.409988390945454 no 1988 0.416503211036277 2824 2913 A selective serotonin reuptake inhibitor. SGTC_2387 9077560 195.08 µM -0.210899099399144 0.409967824071596 no 1989 0.416483003448775 2779 5303272 SGTC_2556 citropten 84.59 µM -0.21334875493755 0.40899533181035 no 1990 0.415527473941354 2793 2775 A potential DNA crosslinker. SGTC_2328 6201408 200 µM -0.213530746297635 0.408923105070735 no 1991 0.415456504994309 2893 2890418 SGTC_2264 7948757 110.76 µM -0.214129008410853 0.408685695154651 no 1992 0.415223227474096 2755 2971411 SGTC_1217 1183-1422 255 µM -0.214341253296384 0.408601477509577 no 1993 0.415140475005332 2912 2849664 SGTC_3102 9121669 49.47 µM -0.215019367725787 0.408332433601106 no 1994 0.414876109224063 2807 41905072 SGTC_2749 bexarotene 57.39 µM -0.215124884935454 0.408290573216891 no 1995 0.414834976355608 2873 82146 An retinoic acid receptor inhibitor. SGTC_1065 prochlorperazine maleate 2.48 µM -0.215339261446841 0.408205529809942 no 1996 0.414751410675531 2802 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_923 1900-2434 73.3 µM -0.217489221540298 0.407352877939584 no 1997 0.413913552972154 2763 5910570 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.217928186925119 0.407178842630879 no 1998 0.41374253246416 2778 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1724 st037281 8.293 µM -0.218574956616544 0.406922453160198 no 1999 0.413490581408962 2791 574124 YDL195W SEC31 SGTC_1160 4092-0570 10.5 µM -0.220065504765227 0.406331728957078 no 2000 0.412910069733799 2795 4994975 SGTC_980 1473-0395 201 µM -0.22016651956323 0.406291703135741 no 2001 0.412870735195975 2790 768876 SGTC_2125 5246583 200 µM -0.221067612379797 0.40593470001097 no 2002 0.412519893975755 2878 835267 SGTC_2684 capsaicin 100 µM -0.221309795210247 0.405838763143104 no 2003 0.412425611797513 2883 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1456 k015-0012 13 µM -0.225577911101355 0.404148950088605 no 2004 0.410764861221396 2816 2989616 SGTC_1152 3909-8331 15.9 µM -0.22571179380701 0.404095972597919 no 2005 0.410712792326055 2815 16001939 SGTC_1062 mesoridazine 14.2 µM -0.227512183059689 0.403383728405247 no 2006 0.410012748449399 2788 4078 A neuroleptic. SGTC_2853 9015042 58.44 µM -0.228312749265167 0.403067122630311 no 2007 0.409701556902338 2765 6457456 SGTC_1271 0832-2808 169 µM -0.228421252600255 0.403024216907266 no 2008 0.409659384474725 2967 3663794 SGTC_3193 9111931 49.47 µM -0.229501338468523 0.402597179812604 no 2009 0.409239640220238 2822 17087244 SGTC_727 3032-0951 202 µM -0.230427297770757 0.402231172726162 no 2010 0.408879875622367 2889 3652836 SGTC_2140 5586273 200 µM -0.231362432409232 0.401861625853382 no 2011 0.408516624013973 2794 854421 SGTC_2051 5263410 176 µM -0.23144066694401 0.401830713071462 no 2012 0.408486237487585 2823 227584 SGTC_2421 5690543 90.72 µM -0.231571980080066 0.401778828742723 no 2013 0.408435236311159 2901 3397993 SGTC_808 0711-0032 135 µM -0.231671287984172 0.401739591442203 no 2014 0.408396666790595 2784 4252555 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.231903093051739 0.401648007370002 no 2015 0.408306641052678 2867 4213774 SGTC_649 1123-0311 367 µM -0.231975352121223 0.401619459573499 no 2016 0.408278578910531 2913 693629 YIL048W NEO1 SGTC_345 1362-0200 395 µM -0.232450648047392 0.40143169483324 no 2017 0.408094007279594 2835 1419823 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.232995565846865 0.401216454110045 no 2018 0.407882424484199 2829 2724 A muscle relaxant with antifungal properties. SGTC_1671 st016596 74.5 µM -0.23430218255346 0.400700467072557 no 2019 0.407375195823115 2856 2829167 SGTC_217 ketoconazole 989 nM -0.23447144242759 0.400633638470588 no 2020 0.40730950047439 2892 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1925 st057770 10.1 µM -0.236053196142595 0.400009258049887 no 2021 0.406695695868794 2817 5989122 SGTC_820 1582-0060 59.9 µM -0.236612525137523 0.399788529964235 no 2022 0.406478701221601 2877 3848840 SGTC_2868 9035608 32.47 µM -0.237078169145293 0.399604797219106 no 2023 0.406298074063025 2768 6462614 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.238133122919201 0.399188618269296 no 2024 0.405888922592822 2834 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1759 st043059 70 µM -0.238455969240266 0.399061278363055 no 2025 0.405763730945573 2825 669426 SGTC_2605 digitonin 300 nM -0.238461619819143 0.399059049707278 no 2026 0.405761539879614 2896 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2277 7947813 106.88 µM -0.238900380393469 0.398886007350708 no 2027 0.40559141529406 3065 1246798 SGTC_1763 st044482 94.5 µM -0.239665666307214 0.398584234559264 no 2028 0.405294726793537 2962 88505 SGTC_3082 9117008 49.47 µM -0.240011795402243 0.398447766460993 no 2029 0.405160556214784 2864 41448529 SGTC_1124 fisetin 1.16336 µM -0.240447008479491 0.39827619290286 no 2030 0.404991869688156 2889 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2080 5212524 12.4 µM -0.241200889044086 0.397979037973672 no 2031 0.404699710940644 2863 260183 SGTC_685 1278-0033 54.9 µM -0.241228657137902 0.397968093832981 no 2032 0.404688950711606 2965 3590572 SGTC_657 3534-0529 86.7 µM -0.244350486910231 0.396738211911692 no 2033 0.40347969265894 2998 1049549 SGTC_1656 st012921 11 µM -0.246859336222299 0.395750564233938 no 2034 0.402508543743342 2963 6732821 SGTC_2191 5911152 200 µM -0.249528571858792 0.394700512549918 no 2035 0.401475971284172 2898 2875902 SGTC_1344 1488-0097 29.1 µM -0.24993065944714 0.3945424012231 no 2036 0.401320486330441 2945 747966 SGTC_1559 coumarin 343 70.1 µM -0.251173364445926 0.394053847123629 no 2037 0.400840038338841 3004 108770 A hepatotoxic, DNA x-linker. SGTC_1621 st003705 32.4 µM -0.25167052370002 0.39385844174543 no 2038 0.400647871227372 3016 24207032 SGTC_1212 0520-0165 585 µM -0.251679634518477 0.393854861043616 no 2039 0.400644349844257 3260 5403258 SGTC_2402 5553605 200 µM -0.252435069756254 0.39355799379235 no 2040 0.400352397948782 3037 6758546 SGTC_1127 asiatic acid 681.4 nM -0.252780597595195 0.393422230557483 no 2041 0.400218880880884 2826 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_129 0088-0017 176.636 µM -0.255816786689869 0.392229823792542 no 2042 0.399046155603794 2966 182446 SGTC_938 3126-1755 342 µM -0.256533891660702 0.391948341370438 no 2043 0.398769307006306 3020 1777771 SGTC_347 4534-1311 26.2 µM -0.257176279566709 0.391696235355198 no 2044 0.398521347235275 2820 2862016 SGTC_508 roscovitine 141 µM -0.25953062375561 0.390772659247167 no 2045 0.397612928449687 2844 160355 A CDKinase inhibitor. SGTC_1561 5-methoxyflavone 52.9 µM -0.262278995267254 0.38969529106145 no 2046 0.396553177346367 2849 94525 SGTC_383 2324-0395 7.37 µM -0.262697182851908 0.389531434575454 no 2047 0.39639199415374 3002 3146421 SGTC_665 3914-0008 307 µM -0.263015237148089 0.389406825992425 no 2048 0.396269417463091 2872 1069549 SGTC_300 r073-0011 5.04 µM -0.264577250388064 0.388795019477036 no 2049 0.395667573659147 2942 2735780 SGTC_1200 1643-0193 18.4 µM -0.265724544190943 0.388345825044519 no 2050 0.395225679608049 2906 5403974 SGTC_3337 9144342 33.5465 µM -0.267200846156505 0.387768035356813 no 2051 0.394657262345365 2961 17682949 SGTC_2567 aureobasidin a 60 nM -0.267498227036436 0.387651677530431 no 2052 0.394542789536547 3133 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1194 1488-0194 225 µM -0.267732912328768 0.387559858068295 no 2053 0.394452456987217 2852 1391452 SGTC_138 0850-0259 40.9225 µM -0.267747935102761 0.387553980696227 no 2054 0.394446674775176 2959 6813004 SGTC_1341 1486-1360 280 µM -0.268747344884729 0.387163038737673 no 2055 0.394062057820273 2855 3976547 SGTC_1290 0986-0249 10.2 µM -0.268796528118547 0.387143802543528 no 2056 0.394043132606801 2948 53329 SGTC_1654 st012436 41.8 µM -0.268815533153819 0.387136369504489 no 2057 0.394035819727481 2927 4323132 SGTC_1436 4092-1007 8.32 µM -0.26965537501573 0.386807941211097 no 2058 0.393712697330601 2903 2881121 SGTC_1895 st058434 18.3 µM -0.270539569650615 0.386462255911926 no 2059 0.393372589632039 3055 5393175 SGTC_3151 9099821 49.47 µM -0.270897591269225 0.386322309159256 no 2060 0.393234898836568 3010 17174189 SGTC_318 1488-0629 67.2 µM -0.272835812151149 0.385564936866772 no 2061 0.392489714715511 2957 3662576 SGTC_2895 9054447 58.44 µM -0.273741635885721 0.385211129769466 no 2062 0.39214158929957 2899 2697450 SGTC_1877 wortmannin 25 µM -0.27415968201092 0.385047876684133 no 2063 0.391980955256699 3029 312145 A covalent inhibitor of PI 3-kinase. SGTC_1340 1486-1359 257 µM -0.274286379570105 0.384998403468257 no 2064 0.391932275408319 2895 4309068 SGTC_740 k014-0057 261 µM -0.276300523131816 0.384212167022568 no 2065 0.391158627074698 2991 4012779 SGTC_2967 9089538 49.85 µM -0.276375174079754 0.384183035582615 no 2066 0.391129961314513 3128 728216 SGTC_1063 disulfiram 1.84 µM -0.277218456441308 0.383854002457688 no 2067 0.390806184300225 2892 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2228 7354201 200 µM -0.277259630373176 0.383837939295293 no 2068 0.390790377566133 2917 753451 SGTC_1419 3993-2473 62.6 µM -0.2775876360794 0.383709981747773 no 2069 0.390664462131014 2917 704026 SGTC_1959 st077091 55.8 µM -0.278385809571892 0.383398661126306 no 2070 0.390358105735262 2856 821356 YKL052C ASK1 SGTC_1377 2944-0135 198 µM -0.278835311292234 0.383223370012416 no 2071 0.390185607118447 2982 1894137 SGTC_2122 5258151 111.688 µM -0.279190991291004 0.383084683271816 no 2072 0.390049128393757 2923 2173356 SGTC_778 3456-2434 196 µM -0.279591898332553 0.382928379567844 no 2073 0.389895311752054 3047 5539063 SGTC_2964 9083345 53.42 µM -0.279795926927107 0.382848841200613 no 2074 0.389817038395107 2961 17741579 SGTC_418 lividomycin a 100 µM -0.280105627119244 0.382728117331775 no 2075 0.389698233815898 3016 72394 An antibiotic. SGTC_2384 9036245 200 µM -0.280621868004018 0.38252690740736 no 2076 0.389500220747882 2948 6462766 SGTC_1646 st011709 75.6 µM -0.280861600673907 0.382433480037109 no 2077 0.389408276910174 3014 5757843 SGTC_1567 st069303 68.4 µM -0.283516263309853 0.381399377285318 no 2078 0.388390558286259 3006 5581319 SGTC_337 1315-0038 354 µM -0.283802406196955 0.38128796298237 no 2079 0.388280905219195 2937 1626437 SGTC_1007 4101-0031 70 µM -0.284977822417495 0.380830399207007 no 2080 0.387830566441238 3067 1146276 SGTC_305 1682-2595 20.8 µM -0.28503371012074 0.380808647493263 no 2081 0.387809157862838 2962 226033 SGTC_610 4215-0184 155 µM -0.287668961974427 0.379783425903328 no 2082 0.386800075450872 2963 5605015 SGTC_2091 4-phenylthiadiazole 200 µM -0.288090737350951 0.379619416102379 no 2083 0.386638641361296 2907 270010 SGTC_1590 st077108 57.8 µM -0.290603622475118 0.378642715953276 no 2084 0.385677244631142 3012 5489485 SGTC_2049 5262831 67.185 µM -0.29128930688732 0.378376340590021 no 2085 0.38541503245528 2986 763417 SGTC_999 SEC7.066 22.7 µM -0.295346800404424 0.376801268127804 no 2086 0.383864484291912 2927 740511 YDR170C SEC7 SGTC_3141 9094609 49.47 µM -0.295982172248024 0.376554808891006 no 2087 0.383621848113024 2880 25236309 YDL196W YDL196W SGTC_2466 5983409 37.09 µM -0.298091948000376 0.375736793266314 no 2088 0.382816493468613 2955 2879657 SGTC_1893 st059353 36.1 µM -0.298958369485322 0.375401020312673 no 2089 0.382485905002699 2989 3112488 SGTC_176 1486-1328 72.834 µM -0.300978884376521 0.374618357075472 no 2090 0.381715298109048 3004 22310231 SGTC_2365 9042475 200 µM -0.302013920666764 0.37421762691738 no 2091 0.381320725508971 3062 6464479 SGTC_73 0327-0325 16.231 µM -0.302740085571514 0.373936562118381 no 2092 0.381043973272878 3055 53298 SGTC_1364 1653-0028 37.6 µM -0.303005230618554 0.373833953445498 no 2093 0.380942937709836 2994 5718652 SGTC_1240 0356-0016 42.1 µM -0.303159206808232 0.373774370192019 no 2094 0.380884267621521 2969 4305613 SGTC_995 3931-2021 34.6 µM -0.303238572267583 0.373743659788649 no 2095 0.380854027791324 3034 730143 SGTC_2824 7998404 51.95 µM -0.303779092734697 0.373534527139314 no 2096 0.380648098028517 2918 837851 SGTC_3216 9129716 49.47 µM -0.304334270337025 0.373319762267515 no 2097 0.38043661932748 2956 8056934 SGTC_2497 7-hydroxyflavone 100 µM -0.304541041718163 0.373239784891017 no 2098 0.380357864934034 3104 5281894 SGTC_2641 levomentholum 100 µM -0.305233490195457 0.372971991611626 no 2099 0.380094163597831 3010 16666 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.305536653038888 0.372854767579191 no 2100 0.379978729297416 3069 688662 SGTC_540 1187-0821 17.3 µM -0.305544585942821 0.37285170031978 no 2101 0.379975708855664 2949 847520 SGTC_658 3253-0951 102 µM -0.306528740995674 0.372471239097626 no 2102 0.379601050084109 2988 1184878 SGTC_2143 5623677 140.463 µM -0.307012684768622 0.37228419849548 no 2103 0.379416858570493 2956 5375313 SGTC_493 zm226600 134 µM -0.307088994374021 0.372254708159504 no 2104 0.379387817234975 3124 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1129 3453-1384 223 µM -0.308481287930765 0.371716779081596 no 2105 0.378858068264227 3155 1084452 SGTC_66 0109-0187 42.4 µM -0.310547938185496 0.370918766223115 no 2106 0.378072155342952 2866 759417 SGTC_3196 9111891 49.47 µM -0.311115607674236 0.370699664269312 no 2107 0.37785636816764 2925 18891510 SGTC_3105 9121040 49.47 µM -0.311916040027834 0.370390794671163 no 2108 0.377552166028411 2964 41448907 SGTC_856 0433-0016 11.3 µM -0.312509946651314 0.370161672878424 no 2109 0.377326502498453 3037 3911780 SGTC_3013 9080133 71.4286 µM -0.314034869874148 0.369573587618857 no 2110 0.376747277546244 3177 17050193 SGTC_1905 st060207 84.5 µM -0.314613305081796 0.369350594314895 no 2111 0.376527637911815 2926 1948547 SGTC_618 k072-0232 33.2 µM -0.31502755064333 0.36919092497606 no 2112 0.376370367852408 3038 5872756 YGL099W LSG1 SGTC_2611 pyromycin 23.93 µM -0.315317858698224 0.369079040313333 no 2113 0.376260163414843 2987 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.315458858838638 0.369024702890284 no 2114 0.376206641700676 2969 688669 SGTC_1010 4112-3296 15.2 µM -0.315778630646417 0.368901481678117 no 2115 0.376085269543117 3119 704384 SGTC_1663 st014140 55.4 µM -0.31592485683414 0.368845139210422 no 2116 0.376029772210544 2988 4207120 SGTC_471 1-acyl-paf 4 µM -0.317667648414064 0.368173840825654 no 2117 0.375368526905526 2952 16759367 SGTC_2807 7945238 51.95 µM -0.318710352249437 0.367772398437715 no 2118 0.374973081884508 3062 17148797 SGTC_634 1611-4317 11.2 µM -0.320294940846412 0.367162606277004 no 2119 0.37437237896944 3024 2843522 SGTC_783 0848-0141 92.7 µM -0.321176050219655 0.366823676567443 no 2120 0.374038490312929 2929 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1618 st003135 44.5 µM -0.321466440748641 0.366711996956729 no 2121 0.373928470060595 3035 1270615 SGTC_3014 9081533 49.47 µM -0.321565752353838 0.366673805870558 no 2122 0.373890846231562 3120 21367265 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.3227417657301 0.366221660805961 no 2123 0.373445409421801 2906 88881 An O-methylated flavonoid and antioxidant. SGTC_2534 helenine 20.12 µM -0.32276643033069 0.366212179925566 no 2124 0.373436069056116 2920 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_3275 9138069 49.47 µM -0.323999243939268 0.365738400146594 no 2125 0.372969303316717 3075 17617007 SGTC_3055 9094636 49.47 µM -0.324067433704869 0.365712200262061 no 2126 0.372943490861046 3159 25236176 SGTC_1024 4507-0395 26 µM -0.325479274789281 0.365169883326856 no 2127 0.372409182892974 3142 4201836 SGTC_1764 st044502 93.5 µM -0.325559698983911 0.365138998858829 no 2128 0.372378753924728 3113 8407 SGTC_988 1497-1057 103 µM -0.32645026073587 0.364797064194082 no 2129 0.372041857930784 3046 3533044 SGTC_1954 st077032 68.9 µM -0.327198310391563 0.364509930674041 no 2130 0.371758949366923 3059 698907 SGTC_2945 9067681 61.76 µM -0.327412500652267 0.36442772926132 no 2131 0.371677956447235 2973 16456930 SGTC_2238 6671620 73.2395 µM -0.32806726926078 0.36417648244546 no 2132 0.371430400491922 2916 729941 SGTC_2201 6605497 169.863 µM -0.328254209168283 0.364104760853291 no 2133 0.371359731708116 3017 670741 SGTC_882 0843-0131 351 µM -0.329667193962607 0.363562807492174 no 2134 0.370825722307808 3081 5425421 SGTC_2528 xanthyletin 44.79 µM -0.330187319382292 0.36336338093122 no 2135 0.370629213857677 2974 65188 An natural product with antifungal activity of unknown mechanism. SGTC_832 4083-0019 164 µM -0.331694647086819 0.362785650448351 no 2136 0.370059921537921 3121 1990758 SGTC_694 1315-0438 43.2 µM -0.332154506268123 0.362609457127463 no 2137 0.369886297056956 3023 6793154 SGTC_474 dl-dihydrosphingosine 5 µM -0.332505381466047 0.36247504017489 no 2138 0.36975383841438 3135 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2281 7943571 200 µM -0.334648447695454 0.361654420370175 no 2139 0.368945146988459 3214 1244024 SGTC_1469 k284-2957 126 µM -0.335569624638331 0.361301879810663 no 2140 0.368597716524752 3025 23884841 SGTC_1622 st003707 19.4 µM -0.335910685793413 0.361171383284305 no 2141 0.368469109358138 3124 10140899 SGTC_3143 9086658 49.47 µM -0.336357957386086 0.361000273096893 no 2142 0.368300474745602 3050 25236626 SGTC_545 4218-0007 221 µM -0.336389145057685 0.360988342841031 no 2143 0.368288717017215 3117 2840508 SGTC_2179 6298986 200 µM -0.337809454480941 0.360445173731763 no 2144 0.367753392330483 3143 738374 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.338156916693279 0.360312336529887 no 2145 0.367622470417275 3015 689007 SGTC_653 0203-0016 55.2 µM -0.338330750867974 0.360245884851955 no 2146 0.367556976396936 3045 295302 SGTC_3280 9140961 49.47 µM -0.34084186597043 0.35928643152125 no 2147 0.366611315541203 2984 4901226 SGTC_1097 itavastatin 7.23 µM -0.340842524544929 0.359286180007448 no 2148 0.366611067634516 3039 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1496 4469-0713 57.4 µM -0.341143815664433 0.359171121403374 no 2149 0.366497658689976 3115 746691 SGTC_2204 7233102 200 µM -0.341195752125114 0.359151288930613 no 2150 0.366478110472249 3013 2172480 SGTC_2886 9058944 51.95 µM -0.341333596507485 0.359098653473242 no 2151 0.366426229294426 3039 4949929 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.341873810712505 0.358892400113395 no 2152 0.366222929715841 3020 2724278 An inhibitor of dopamine biosynthesis. SGTC_2966 9084041 48.03 µM -0.34246690167144 0.358666005820932 no 2153 0.365999774190259 2913 17741380 SGTC_926 2268-1401 59.4 µM -0.344144281541221 0.358025986496128 no 2154 0.365368891299391 3009 2931578 SGTC_1554 st069299 38.7 µM -0.344181852705841 0.358011655441458 no 2155 0.365354764492135 3086 24207999 SGTC_1248 0469-0687 58.6 µM -0.34473086204211 0.357802265473608 no 2156 0.365148357107348 3115 4017482 SGTC_792 4534-1957 155 µM -0.345628103379716 0.357460153326359 no 2157 0.364811111363376 3026 1717904 SGTC_3035 9091303 49.47 µM -0.346438281580885 0.357151336149624 no 2158 0.364506679839146 3035 25237002 SGTC_1073 triclabendazole 3.09 µM -0.346947842977745 0.356957153566575 no 2159 0.364315251454702 3094 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1951 sophoraflavanone G 9.2 µM -0.34707853653807 0.35690735510853 no 2160 0.364266158882813 3029 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_3335 9143315 29.6265 µM -0.347106912207697 0.356896543386126 no 2161 0.364255500391703 3015 4899691 SGTC_707 0865-0008 204 µM -0.347946109006312 0.356576843889794 no 2162 0.363940328132024 3016 723043 SGTC_570 0987-0065 62.6 µM -0.348392703401718 0.356406750832469 no 2163 0.363772640773979 2970 3104428 SGTC_3084 9116877 49.47 µM -0.348940694540829 0.356198078129226 no 2164 0.363566916593969 3091 27241325 SGTC_205 1486-1330 71.903 µM -0.349366046485605 0.356036135589642 no 2165 0.363407260138466 3027 4118834 SGTC_2198 6589944 200 µM -0.350422591926764 0.355633993699501 no 2166 0.363010787014401 3068 5290268 SGTC_1357 1503-1303 39.5 µM -0.350461894550766 0.355619037447124 no 2167 0.362996041368162 3046 292895 SGTC_724 3910-0327 137 µM -0.35061762733281 0.355559776953721 no 2168 0.362937615192268 3101 2885483 SGTC_3124 9127567 49.47 µM -0.350773737575803 0.355500376330386 no 2169 0.362879050606317 3209 17592030 SGTC_1427 4048-4900 550 nM -0.351175340192769 0.355347580926768 no 2170 0.362728404565866 3139 24132586 SGTC_2820 7989630 71.43 µM -0.35121753532959 0.355331528538633 no 2171 0.36271257788828 3103 2984098 SGTC_2222 6885208 172.143 µM -0.351871109603205 0.355082920643073 no 2172 0.362467463270803 3064 609514 SGTC_2107 5363541 170.161 µM -0.352132618383068 0.354983464678574 no 2173 0.362369403552246 3126 244052 SGTC_2932 9016711 44.54 µM -0.352219875929391 0.354950281438547 no 2174 0.362336686007842 3165 7117328 SGTC_1613 st002381 52.1 µM -0.353862411637955 0.354325845799254 no 2175 0.361720998935947 3079 551167 SGTC_2773 thioridazine 9.09 µM -0.354390098120988 0.354125320522106 no 2176 0.36152327711865 3067 5452 An antipsychotic. SGTC_812 4251-0442 148 µM -0.354830229394348 0.353958097890044 no 2177 0.361358390132536 3169 5723007 SGTC_3252 9135871 49.47 µM -0.355419141395921 0.353734391854981 no 2178 0.361137805497752 3179 17682838 SGTC_1198 1612-1005 86.7 µM -0.356065075072072 0.353489083449509 no 2179 0.360895915744364 3210 6998509 SGTC_2349 9023730 187.07 µM -0.356708486607778 0.353244793369316 no 2180 0.360655025785524 3178 4126287 SGTC_2673 kobusone 100 µM -0.358179044086777 0.352686680184856 no 2181 0.360104664353901 3053 6710676 An epoxy ketone and protein crosslinker. SGTC_1223 0764-0573 147 µM -0.359581094645027 0.352154862156768 no 2182 0.359580211743497 3037 1609797 SGTC_1557 sumaresinolic acid 42.3 µM -0.359589840186396 0.35215154575256 no 2183 0.359576941205079 3039 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1699 st031318 29.054 µM -0.360610779745876 0.351764471724739 no 2184 0.359195214877686 3147 5340658 SGTC_2536 dehydroabietamide 32.04 µM -0.3611651091085 0.351554370318828 no 2185 0.358988011579343 3172 3983547 SGTC_1712 st032288 53.4 µM -0.361643755986849 0.351372990492427 no 2186 0.358809131077372 3138 2883011 SGTC_1874 staurosporine 7.6 µM -0.362762790266574 0.350949072525948 no 2187 0.358391045075267 3159 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_499 genistein 192 µM -0.362807929992661 0.3509319763649 no 2188 0.358374183834178 3113 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_521 r062-0005 13.8 µM -0.364131776523503 0.350430718789401 no 2189 0.357879804526028 3015 2832033 SGTC_601 0986-0029 62.9 µM -0.365055158607112 0.350081246036196 no 2190 0.357535116289947 3064 24747981 SGTC_1706 st031321 9.9705 µM -0.365448668195603 0.349932352873657 no 2191 0.357388258835917 3151 6103185 SGTC_2388 9080168 200 µM -0.366231344432082 0.349636278395962 no 2192 0.357096227500679 3027 15943073 SGTC_748 act1.228 77.9 µM -0.366340948864812 0.349594824006155 no 2193 0.357055338687302 3038 4421505 YNR035C ARC35 SGTC_430 0958-0115 16.4 µM -0.367038334929647 0.349331101940985 no 2194 0.356795211692071 3061 6833180 SGTC_1512 0259-0544 12.2 µM -0.369344986574985 0.34845934201954 no 2195 0.355935298905262 3078 18476 SGTC_65 0798-0905 34.986 µM -0.370151701524804 0.34815464630087 no 2196 0.355634730637645 3422 3602145 SGTC_3025 9087895 49.47 µM -0.371534813226172 0.347632474013008 no 2197 0.355119615660097 3179 17173641 SGTC_2965 9082772 38.63 µM -0.372783912956017 0.347161144116829 no 2198 0.354654638414722 3255 16459634 SGTC_768 0384-0033 77.3 µM -0.374627091687739 0.34646607879264 no 2199 0.353968910875674 3071 3965305 YMR134W ERG29 SGTC_148 3253-0744 288.01 µM -0.376929594923419 0.34559852751376 no 2200 0.353112963609882 3112 6893655 SGTC_410 α-linolenic acid 100 µM -0.377441094424102 0.34540591143718 no 2201 0.352922916179511 3189 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1677 st019204 53.9 µM -0.377471732875421 0.345394375143223 no 2202 0.352911533639609 3150 3945625 SGTC_2834 9001755 58.44 µM -0.377757900948672 0.345286631235152 no 2203 0.352805225240464 3080 2989575 SGTC_1300 1094-0077 113 µM -0.378271642744291 0.345093235987626 no 2204 0.352614404459195 3067 5532636 SGTC_804 1595-0054 20.9 µM -0.378617715478532 0.344962981627455 no 2205 0.352485882440357 3066 761523 Stimulates phospholipase C. SGTC_3002 9075603 71.4286 µM -0.379006752443076 0.344816578384485 no 2206 0.352341424777974 3103 20105405 SGTC_1184 1269-1718 139 µM -0.380351801459316 0.344310585736442 no 2207 0.351842143829514 3217 5403821 SGTC_3317 9138495 8.753 µM -0.380964763387641 0.344080088536413 no 2208 0.351614697586439 3080 17020139 SGTC_3074 9116018 49.47 µM -0.380979522228609 0.344074539359782 no 2209 0.351609221811151 3041 17027303 SGTC_31 0508-1974 57.237 µM -0.381438486943589 0.343901989980034 no 2210 0.351438953645341 3184 6810525 SGTC_197 4544-0043 41.561 µM -0.38267312587505 0.343437984600215 no 2211 0.350981071449791 3082 896523 SGTC_289 k017-0060 526 µM -0.383011054753693 0.343311024327564 no 2212 0.35085578372572 3092 5512909 SGTC_3273 9137859 49.47 µM -0.383068209840071 0.343289552842862 no 2213 0.350834594980105 3158 2377234 SGTC_2235 salicylic acid 500 µM -0.384965547233269 0.34257706647483 no 2214 0.350131470695647 3142 338 A COX inhibitor and kinase inhibitor. SGTC_2424 5537928 59.2 µM -0.385202848323884 0.342487994720484 no 2215 0.350043566608221 3088 5382802 SGTC_1728 st035614 33.7865 µM -0.386940007018801 0.341836213454718 no 2216 0.349400311167225 3125 15945546 SGTC_3291 9121177 71.43 µM -0.389082975598316 0.341032821692519 no 2217 0.348607383360737 3103 17015612 SGTC_1666 st014829 29 µM -0.390462195244261 0.340516137533027 no 2218 0.348097402493567 3058 3858230 SGTC_2811 7967822 32.47 µM -0.390629628146482 0.340453434055259 no 2219 0.348035511102095 3231 2232244 SGTC_1605 st000082 49.1 µM -0.391189464613429 0.340243807813893 no 2220 0.347828597559627 3204 1114022 SGTC_2531 methyl deoxycholate 70.07 µM -0.391553620249902 0.340107479171309 no 2221 0.347694031265738 3054 16667744 Haematoxylin. SGTC_102 gallobenzophenone 83.616 µM -0.392024090615697 0.339931380518755 no 2222 0.347520206938104 3268 70837 SGTC_271 rotenone 740 µM -0.393258998379768 0.339469316568813 no 2223 0.347064099093386 3217 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2393 9031399 185.94 µM -0.393556017821739 0.339358217122484 no 2224 0.346954429261066 3231 1526623 YDL150W RPC53 SGTC_560 2332-1943 155 µM -0.393852957252537 0.339247161560335 no 2225 0.346844801785427 3116 21177716 SGTC_146 3448-8650 53.125 µM -0.394889737208965 0.338859514646478 no 2226 0.34646213215145 3102 2891488 YIL048W NEO1 SGTC_2785 7756463 72.73 µM -0.399994078398725 0.33695352068531 no 2227 0.344580439141191 3075 2201551 SGTC_2105 5350118 200 µM -0.400386456772707 0.336807176425087 no 2228 0.344435948902889 3149 2133313 SGTC_1430 4049-0248 69.1 µM -0.401254177506893 0.336483632810935 no 2229 0.344116498219846 3210 22774488 SGTC_2073 5212005 126 µM -0.401345611678032 0.336449547156086 no 2230 0.344082843276972 3124 691789 SGTC_3184 9108758 49.47 µM -0.401780109065954 0.33628758967446 no 2231 0.343922931058875 3082 902885 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.401908201347499 0.336239849491513 no 2232 0.343875793361141 3257 16725076 SGTC_2469 5655019 90.81 µM -0.403294678776074 0.335723276427211 no 2233 0.343365727924101 3233 2788239 SGTC_1741 st038134 10.228 µM -0.40374715386657 0.335554760587295 no 2234 0.343199330406885 3337 1272587 SGTC_637 1181-0519 7.26 µM -0.404077023347745 0.335431927742935 no 2235 0.343078040204616 3165 6252091 YGR060W ERG25 SGTC_2019 4016004 108 µM -0.40429173227483 0.335351986454673 no 2236 0.342999102243398 3166 45595336 SGTC_678 1218-2179 85.9 µM -0.404513699484606 0.33526935057038 no 2237 0.342917502970283 3176 6820081 YOR116C RPO31 SGTC_116 0155-0182 31.788 µM -0.405579325581873 0.334872741061055 no 2238 0.342525861079337 3119 771486 SGTC_224 benfluorex 43.875 µM -0.407564816466117 0.334134263476885 no 2239 0.341796599589278 3235 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1368 1852-0141 284 µM -0.409015392158543 0.333595146099565 no 2240 0.341264182718077 3218 2838987 SGTC_1090 efavirenz 20.7 µM -0.409677146439424 0.333349314146541 no 2241 0.341021398373694 3155 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1086 cerivastatin 2.18 µM -0.413493955428736 0.331932825411433 no 2242 0.339622375059889 3209 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1305 1181-0477 144 µM -0.413687043157862 0.331861230547279 no 2243 0.339551658656807 3258 6252086 SGTC_2418 pentamidine 31.67 µM -0.414097080336017 0.33170921351353 no 2244 0.339401505476418 3227 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_674 0498-0004 451 µM -0.414406817058922 0.331594400203325 no 2245 0.339288098628056 3199 4231473 SGTC_1281 0884-0031 11.8 µM -0.415108803320128 0.331334246277011 no 2246 0.339031127621869 3151 1548255 SGTC_327 1273-0057 3.96 µM -0.415552448440113 0.331169874728992 no 2247 0.338868764282549 3149 3108138 SGTC_2617 dihydrotanshinone i 20.83 µM -0.415843634153917 0.331062007423916 no 2248 0.338762213650712 3128 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_140 0062-0056 502.533 µM -0.415846484851973 0.33106095147602 no 2249 0.338761170587473 3094 3758964 SGTC_3117 9124945 49.47 µM -0.41585384885988 0.331058223726265 no 2250 0.338758476121249 3074 17592065 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.419169524523742 0.329830955711369 no 2251 0.337546121414274 3345 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2375 9072683 200 µM -0.419654775491301 0.32965149752947 no 2252 0.337368833614607 3313 16798029 SGTC_1781 st038725 66.3 µM -0.419842691936538 0.329582011767562 no 2253 0.337300187509872 3119 4270275 YIL048W NEO1 SGTC_58 0957-0393 9 µM -0.420645089307691 0.329285375943317 no 2254 0.337007131737201 3266 6997992 SGTC_638 3970-0837 4.09 µM -0.421479699017542 0.328976945617684 no 2255 0.336702416139433 3164 4118451 YLR208W SEC13 SGTC_2473 5854593 8.94 µM -0.42232058999341 0.328666311765873 no 2256 0.336395515639109 3077 2872951 SGTC_2185 6113692 200 µM -0.422897447086419 0.328453283197464 no 2257 0.336185042755149 3258 874150 SGTC_2875 9039966 71.43 µM -0.423044664223191 0.328398926049979 no 2258 0.336131337125731 3196 6463691 SGTC_309 k408-0051 1.48 µM -0.42367923555982 0.32816466415096 no 2259 0.335899880268749 3206 3640463 SGTC_2557 derrustone 83.84 µM -0.425057894612648 0.32765594362883 no 2260 0.335397235514182 3254 629853 An antioxidant. SGTC_1972 st070201 17.4 µM -0.425137926791782 0.327626421836548 no 2261 0.335368065649565 3267 2829099 SGTC_872 0588-0139 234 µM -0.425463743482132 0.327506247646315 no 2262 0.335249323303498 3148 2047100 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.426512853194989 0.327119415602562 no 2263 0.334867092124926 3118 442882 SGTC_1420 4'-methoxyflavone 42 µM -0.426768374086381 0.327025226988021 no 2264 0.334774021879893 3232 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_3330 9141424 71.43 µM -0.428016044086458 0.326565476506314 no 2265 0.33431971975296 3261 27261020 SGTC_2131 toluylene red 5.2905 µM -0.428205670269938 0.326495624708223 no 2266 0.334250694205345 3143 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_288 1315-0019 35.1 µM -0.428619327055727 0.326343268813461 no 2267 0.334100139059201 3267 6811474 SGTC_1665 st014639 11.4 µM -0.428722206537283 0.326305381280815 no 2268 0.334062699032138 3235 981133 YIL048W NEO1 SGTC_3177 9107506 49.47 µM -0.428860155619572 0.326254581443092 no 2269 0.334012499024652 3230 8897194 SGTC_2661 dactinomycin 12.96 µM -0.429172995242443 0.326139389996539 no 2270 0.333898666928184 3189 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1968 st069590 43.6 µM -0.430234446014722 0.32574867426372 no 2271 0.333512553690158 3253 6384066 SGTC_663 1486-0733 13.9 µM -0.430740724724664 0.325562382482816 no 2272 0.333328451864413 3148 722445 YPR165W RHO1 SGTC_3116 9124943 49.47 µM -0.430828832734745 0.325529966453302 no 2273 0.333296416605 3171 41905195 YPL160W CDC60 SGTC_2437 5741531 144.16 µM -0.431325714642211 0.325347182148085 no 2274 0.33311577770018 3321 2262990 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.433347106640266 0.324604020906839 no 2275 0.332381310305536 3148 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1193 1488-0126 41.5 µM -0.433540798857028 0.32453284689077 no 2276 0.332310966479212 3171 1384710 SGTC_1262 0737-0114 49.6 µM -0.433626327943538 0.324501420467672 no 2277 0.332279906485213 3331 765919 SGTC_2217 6934799 96.0675 µM -0.434861332440575 0.324047775364202 no 2278 0.331831541565589 3244 675606 SGTC_2766 oltipraz 83.91 µM -0.435466283984887 0.323825658219142 no 2279 0.331612003409945 3282 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1185 1319-0113 81.3 µM -0.436625760576971 0.323400114157552 no 2280 0.331191388663476 3263 4672763 SGTC_2026 5148700 152 µM -0.437064600560289 0.323239113975369 no 2281 0.331032249438423 3148 79838 SGTC_789 1309-1135 70.6 µM -0.440315570638542 0.322047441231331 no 2282 0.329854282459932 3233 3092424 SGTC_1257 0669-0121 16 µM -0.441055651518516 0.321776412741344 no 2283 0.329586354263196 3232 4307855 SGTC_166 k072-0058 166.424 µM -0.441553644728666 0.321594093660518 no 2284 0.329406117199495 3332 5846229 SGTC_2545 solidagenone 89.61 µM -0.442626072459785 0.321201615676406 no 2285 0.329018111522221 3133 6708572 An anti ulcer agent SGTC_1298 1079-1278 263 µM -0.444483483552569 0.320522328585806 no 2286 0.328346533740321 3243 2840950 SGTC_3279 9140807 49.47 µM -0.44495806413791 0.320348862592563 no 2287 0.328175030079603 3238 45595718 SGTC_62 0180-0423 3.232 µM -0.445402163434567 0.320186573490551 no 2288 0.32801457452724 3211 30102 YGL099W LSG1 SGTC_3097 9117246 49.47 µM -0.446093400917169 0.319934040060527 no 2289 0.32776488971972 3269 16423892 SGTC_470 aa-861 153 µM -0.446186645694333 0.31989998083813 no 2290 0.327731214270761 3210 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1813 st051246 8.6015 µM -0.446339365504578 0.319844200639704 no 2291 0.327676062377862 3253 5291959 SGTC_725 1497-0963 19 µM -0.447050526298144 0.319584506144595 no 2292 0.32741928953398 3296 3549977 SGTC_697 0508-1955 564 µM -0.448912994823686 0.318904808125834 no 2293 0.326747210748839 3335 6243113 SGTC_3259 9138485 49.47 µM -0.451002990690646 0.318142799847025 no 2294 0.325993696753669 3467 17646153 SGTC_553 k007-0256 45.7 µM -0.45521687364954 0.316608767523711 no 2295 0.324476611171529 3241 6287000 SGTC_2757 clomiphene 4.22 µM -0.455245606852138 0.316598318198453 no 2296 0.324466276575913 3397 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1061 3448-9325 110 µM -0.456302855485567 0.316213933311627 no 2297 0.324086105428681 3290 723482 SGTC_3323 9138564 53.9225 µM -0.45729092179634 0.315854880553849 no 2298 0.323730976981339 3355 43912313 YNL103W MET4 SGTC_1776 st049249 45.9 µM -0.458788434430146 0.315311031590311 no 2299 0.323193050453141 3263 1822314 SGTC_642 0335-0876 158 µM -0.459066882580153 0.315209952139728 no 2300 0.323093068866795 3242 6812350 SGTC_2088 5278280 127.392 µM -0.460851826835777 0.314562328407124 no 2301 0.322452457793706 3317 791502 SGTC_1946 st076057 65.1 µM -0.461013027275934 0.314503868778055 no 2302 0.32239462935491 3242 953009 SGTC_2161 5662504 8.5105 µM -0.463340908357073 0.313660177629071 no 2303 0.321560013771241 3220 2859334 SGTC_2621 lithochol-11-enic acid 100 µM -0.464422691082384 0.313268439499106 no 2304 0.32117246802474 3348 6708711 SGTC_2608 thymoquinone 42.66 µM -0.465021267603001 0.313051771804515 no 2305 0.320958113228856 3302 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1857 st056007 79.3 µM -0.465340360297953 0.312936295683212 no 2306 0.320843868086751 3319 619834 SGTC_2364 9055074 200 µM -0.466175668244423 0.312634093879844 no 2307 0.320544882120962 3291 6470630 SGTC_152 4469-0003 551.229 µM -0.467581676910938 0.312125705600798 no 2308 0.320041885329524 3354 697280 SGTC_1818 st052136 56.3 µM -0.46967054385212 0.311371068064983 no 2309 0.319295207972295 3317 674169 SGTC_3028 9087778 49.47 µM -0.471859523873055 0.310581112687539 no 2310 0.318513530337926 3220 17217395 SGTC_2306 7482397 179.52 µM -0.472152839105506 0.31047532780863 no 2311 0.318408849670274 3359 891448 SGTC_2342 7990637 118.86 µM -0.472227292736836 0.310448478412327 no 2312 0.318382280374076 3330 2033102 YER133W GLC7 SGTC_1362 1611-0397 101 µM -0.472726122202228 0.31026861707058 no 2313 0.31820429371049 3235 27816 SGTC_1687 st020778 55.3625 µM -0.473768767396366 0.309892820397946 no 2314 0.317832404466562 3272 4259299 SGTC_2015 5119600 184 µM -0.474424409622461 0.309656611398982 no 2315 0.317598644941 3368 2828786 SGTC_91 0417-1751 58.384 µM -0.474597337037018 0.309594323728807 no 2316 0.317537002345387 3335 6795624 SGTC_1041 0206-0046 107 µM -0.475845149313562 0.309145029587849 no 2317 0.317092350805151 3263 50494 SGTC_620 0109-0052 432 µM -0.477009920068174 0.308725893248177 no 2318 0.316677528854053 3374 493037 SGTC_731 3966-0296 387 µM -0.477934195160558 0.308393475123069 no 2319 0.316348521072449 3245 660956 SGTC_1187 1391-0724 117 µM -0.478609189092271 0.308150810860223 no 2320 0.316108339966429 3293 6997986 SGTC_1912 st060209 90.8 µM -0.478899227476518 0.308046566110635 no 2321 0.316005160285668 3262 688787 SGTC_1904 st060225 78 µM -0.479357557511079 0.307881866038659 no 2322 0.31584214092418 3327 66595 SGTC_1674 st016616 23.6 µM -0.479975029076802 0.307660039930038 no 2323 0.315622574544892 3187 625830 SGTC_2419 paclitaxel 166.5 µM -0.480217541591689 0.307572936748402 no 2324 0.315536357442626 3258 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2331 7980721 200 µM -0.480579344407468 0.307443008253151 no 2325 0.315407749382445 3256 2981221 SGTC_606 k015-0008 38.6 µM -0.480999047977021 0.307292317046781 no 2326 0.315258587673723 3368 1970475 SGTC_3345 9148410 3.559 µM -0.481955678775902 0.306948968017893 no 2327 0.314918715788407 3331 4903596 SGTC_353 1988-1175 58.3 µM -0.484391137627752 0.306075610042655 no 2328 0.31405415340472 3171 2788357 SGTC_1591 genipin 88.4 µM -0.484631166172072 0.305989595099855 no 2329 0.313969000902923 3360 442424 A DNA cross-linking agent. SGTC_3038 9091290 49.47 µM -0.484677519143322 0.305972985606999 no 2330 0.313952557868546 3383 25236843 SGTC_1464 k208-0027 110 µM -0.486636200014036 0.305271503526808 no 2331 0.313258082599029 3427 X1464 SGTC_1195 1502-0147 41.1 µM -0.487291837604032 0.305036852943145 no 2332 0.31302576563643 3304 817940 SGTC_462 ag-879 158 µM -0.489040288239276 0.304411480082886 no 2333 0.312406587110858 3340 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2801 7907800 81.82 µM -0.489615933749413 0.304205712411173 no 2334 0.312202849591891 3328 6620925 SGTC_2791 5663188 71.43 µM -0.491003376751006 0.303710018071969 no 2335 0.3117120296263 3382 54690634 SGTC_2533 agelasine 13.65 µM -0.49118530724175 0.303645046169472 no 2336 0.311647694914013 3453 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_219 mitoxanthrone 164.414 µM -0.491239087027462 0.303625841258835 no 2337 0.311628678273322 3315 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1016 4226-1401 38 µM -0.491545893600624 0.303516290153394 no 2338 0.31152020045982 3343 2901613 SGTC_914 3820-6779 408 µM -0.492072902602475 0.303328152813623 no 2339 0.311333903707356 3235 2893481 SGTC_3227 9130768 49.47 µM -0.492139182411914 0.30330449522479 no 2340 0.311310477330454 3330 17720899 SGTC_67 0335-0847 266 µM -0.492284534179429 0.303252616968298 no 2341 0.311259105909937 3479 4552207 YOR254C SEC63 SGTC_2511 berberine 10.47 µM -0.493301764650279 0.30288966302745 no 2342 0.310899690849159 3255 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1405 3909-7894 12 µM -0.493499292623618 0.302819206414075 no 2343 0.310829919766442 3361 7104060 SGTC_2876 9059903 25.97 µM -0.494091531257464 0.30260800373701 no 2344 0.310620769253019 3345 6916095 SGTC_672 1441-0018 53.7 µM -0.494514226001 0.302457303765856 no 2345 0.310471530996587 3249 251141 SGTC_2257 7960413 200 µM -0.494570563536814 0.302437220737155 no 2346 0.310451642601497 3253 2974689 YIL048W NEO1 SGTC_564 3555-0129 330 µM -0.496439667538674 0.301771267707157 no 2347 0.309792122040154 3329 563260 SGTC_1853 st056710 91.2 µM -0.496854092104878 0.301623699497396 no 2348 0.30964597351936 3416 269167 SGTC_1668 st014914 51.6 µM -0.498096938815232 0.30118134166212 no 2349 0.309207859043909 3367 2839556 SGTC_890 0929-0006 47.2 µM -0.499518001390268 0.300675911146833 no 2350 0.308707254167281 3279 1378169 SGTC_846 0335-0850 148 µM -0.500934112574058 0.300172622879827 no 2351 0.308208746913306 3342 6819598 SGTC_2120 5538279 151.968 µM -0.502132325403495 0.299747073813742 no 2352 0.307787221505972 3344 2058197 SGTC_213 1246-0773 967 nM -0.50246693223043 0.299628285964757 no 2353 0.307669553729927 3325 6251622 SGTC_1280 0880-0253 10.1 µM -0.50564876186985 0.298499780763867 no 2354 0.306551621914149 3304 6836607 SGTC_1545 lovastatin 49.4 µM -0.505732812580292 0.298469996579148 no 2355 0.306522115130449 3354 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1565 sinapyl alcohol 95.1 µM -0.505814267805311 0.298441133420136 no 2356 0.306493520712772 3352 5280507 A phenol propionate derived from cinnamic acid. SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.50670789182691 0.298124566669437 no 2357 0.306179896206382 3397 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2667 digitoxin 100 µM -0.506710751288708 0.298123553949258 no 2358 0.306178892883149 3347 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_579 4491-1009 110 µM -0.507516901367182 0.297838106646464 no 2359 0.305896090274877 3449 1271041 SGTC_1648 st011736 69.8 µM -0.507978155824723 0.297674838496635 no 2360 0.305734331279743 3434 2855514 SGTC_2904 7225135 42.03 µM -0.508463420201889 0.297503115761639 no 2361 0.305564193066669 3411 4446116 SGTC_1116 jasmonic acid  1.58368 µM -0.508572032765457 0.297464686730395 no 2362 0.305526118237396 3406 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_279 1273-0055 2.93 µM -0.509854523764949 0.297011090421089 no 2363 0.305076691931456 3359 2847562 SGTC_2450 5739737 12.93 µM -0.511622877200046 0.296386171837145 no 2364 0.304457485635351 3383 2262825 SGTC_1135 dihydrocapsaicin 536.708 nM -0.512218338238166 0.296175877545314 no 2365 0.304249105067496 3315 107982 A Capsaicinoid. SGTC_133 0724-0033 378.92 µM -0.513864648752695 0.295594819569028 no 2366 0.303673312420539 3226 280309 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.514062907228879 0.295524880491476 no 2367 0.30360400488088 3409 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2464 5717415 7.67 µM -0.514949205371221 0.295212316706428 no 2368 0.303294257644145 3292 5285744 SGTC_488 nitrendipine 139 µM -0.515619084808605 0.294976176629887 no 2369 0.303060239107193 3374 4507 Dihydropyridine L-type calcium channel blocker. SGTC_3204 9114183 49.47 µM -0.515873742124769 0.294886429882391 no 2370 0.302971297232192 3276 17027248 SGTC_187 1488-2104 32.728 µM -0.51605581926207 0.294822269676791 no 2371 0.302907711947746 3352 2852859 SGTC_1971 st069429 63.5 µM -0.516447772445403 0.294684175348612 no 2372 0.302770853672089 3376 1246522 YGL099W LSG1 SGTC_2128 5255449 168.493 µM -0.517737942915945 0.294229828792585 no 2373 0.302320560645707 3314 736008 SGTC_1684 st024538 14.6195 µM -0.518860705255793 0.293834700245341 no 2374 0.301928940781022 3320 6732859 SGTC_1358 1509-0022 2.48 µM -0.519398583313336 0.293645494319617 no 2375 0.301741409523213 3379 3258434 SGTC_1600 coumarin 106 71.1 µM -0.519742817039118 0.293524435026856 no 2376 0.301621419875617 3447 100336 A hepatotoxic, DNA x-linker. SGTC_559 1550-0661 158 µM -0.520221880816177 0.293355997500353 no 2377 0.301454468205 3392 5830875 SGTC_2383 9036125 200 µM -0.5208925055737 0.293120282915683 no 2378 0.301220828242363 3315 79580 SGTC_23 0213-0011 39.996 µM -0.521636644758563 0.292858831963221 no 2379 0.30096167199147 3448 627608 SGTC_2070 5230947 200 µM -0.523151453344643 0.292326943493527 no 2380 0.300434430864583 3440 2835538 SGTC_607 4491-0986 66.8 µM -0.523323761069864 0.292266470263273 no 2381 0.300374484235715 3439 698981 YDR232W HEM1 SGTC_1159 4092-0538 61.2 µM -0.526860147861496 0.29102662497763 no 2382 0.299145355178967 3395 717301 SGTC_2724 maprotiline 69.64 µM -0.527237949682906 0.290894314336436 no 2383 0.29901417905359 3427 4011 A tricyclic antidepressant. SGTC_2654 protoveratrine a 100 µM -0.527952033380487 0.290644310645299 no 2384 0.29876631426433 3344 5702278 A heart drug and vasodilator. SGTC_2844 9010103 25.97 µM -0.528049046692509 0.290610353635198 no 2385 0.298732647289288 3437 2480525 SGTC_857 0438-0306 1.35 µM -0.528502493607643 0.290451660844389 no 2386 0.298575308397929 3440 4686136 SGTC_1623 st003709 20.3 µM -0.528599117803865 0.290417850523489 no 2387 0.298541786205578 3350 16192618 SGTC_191 3914-0123 66.505 µM -0.528672343324798 0.290392228993186 no 2388 0.298516382943205 3288 3144412 SGTC_2747 doxorubicin 7.63 µM -0.530469813845106 0.289763628104365 no 2389 0.297893116381385 3320 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_942 3253-1115 227 µM -0.531113561175928 0.289538655925676 no 2390 0.297670043653501 3468 46497897 SGTC_1996 st072960 66.8 µM -0.532558500202432 0.28903398793184 no 2391 0.297169618008589 3451 1719405 SGTC_2003 4023581 200 µM -0.532979334744251 0.288887082600252 no 2392 0.29702394275615 3421 16641307 SGTC_1454 4239-0054 42.6 µM -0.536107376338541 0.287796245661446 no 2393 0.295942171233441 3519 1340767 SGTC_2236 dapsone 200 µM -0.537439628505577 0.287332243055648 no 2394 0.295481988036016 3422 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_112 phenothiazine 287.218 µM -0.538053444013146 0.287118579878091 no 2395 0.295270076226827 3442 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_516 3992-2719 87.3 µM -0.539736900784386 0.286532971433902 no 2396 0.294689244005218 3255 5350887 YDR037W KRS1 SGTC_3351 9150312 21.596 µM -0.541440008070112 0.285941104569454 no 2397 0.294102168688489 3392 4904905 SGTC_1005 4092-0690 4.4 µM -0.542031940248435 0.28573553142929 no 2398 0.293898251374457 3348 1529343 SGTC_1788 fluconazole 20 µM -0.542060797959278 0.285725511182974 no 2399 0.293888311726885 3419 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_463 ikarugamyin 104 µM -0.542298267916962 0.285643060974423 no 2400 0.293806524321473 3422 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2585 alliin 100 µM -0.543542341834937 0.285211300278465 no 2401 0.293378223036957 3529 87310 A garlic compound which reacts with lipids. SGTC_901 1112-0062 60.1 µM -0.54464299613144 0.284829573390124 no 2402 0.292999538647751 3389 1908457 SGTC_1998 st075797 76.8 µM -0.545869799241409 0.284404383298122 no 2403 0.292577719728611 3459 24208315 SGTC_2252 omeprazole 400 µM -0.547814525219028 0.28373099485122 no 2404 0.291909631968898 3343 4594 A proton pump inhibitor. SGTC_817 1391-0715 46 µM -0.549382357362203 0.283188667653001 no 2405 0.29137153950362 3368 1353946 SGTC_1431 4049-0260 9.09 µM -0.550462959098147 0.282815167558502 no 2406 0.291000938027941 3420 3854841 SGTC_2489 cantharidin 73.42 µM -0.550737722267247 0.282720235931036 no 2407 0.290906740812566 3445 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3336 9143619 71.43 µM -0.55527441675551 0.281155009856855 no 2408 0.289353487448766 3481 45595730 SGTC_3255 9139072 49.47 µM -0.555538880071567 0.281063895392197 no 2409 0.289263061999857 3464 17646060 SGTC_378 3970-0959 8.33 µM -0.556525081273092 0.280724249367274 no 2410 0.288925976688022 3448 6615653 SGTC_1743 st037606 46.3785 µM -0.558476520879863 0.280052762484229 no 2411 0.288259516486694 3398 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2092 5303694 80.6725 µM -0.559240133445987 0.279790216860188 no 2412 0.287998923257354 3389 1963699 SGTC_1373 2887-0003 58.5 µM -0.56055667644372 0.279337843040366 no 2413 0.287549896291138 3380 776948 SGTC_2172 5754775 163.918 µM -0.560614022980528 0.279318146429433 no 2414 0.287530344909531 3343 2263357 SGTC_2512 diallyl trisulfide 49.23 µM -0.561089770992268 0.27915476897846 no 2415 0.287368170499359 3462 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_98 0074-0023 107.663 µM -0.562189315020094 0.278777350509149 no 2416 0.286993520297026 3432 3563821 SGTC_3039 9090270 49.47 µM -0.562450467541411 0.278687746423929 no 2417 0.286904571201627 3498 17173750 SGTC_6 0844-0013 19.835 µM -0.56257948180705 0.278643485492939 no 2418 0.286860633493671 3527 1584900 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.563165194183359 0.278442588172287 no 2419 0.286661200628102 3461 3256 An antibiotic and ribosome inhibitor. SGTC_1884 5633444 25 µM -0.564017509392337 0.278150373134943 no 2420 0.286371108004929 3488 5724239 SGTC_2018 5133068 143 µM -0.564045740665581 0.278140696643409 no 2421 0.286361501639219 3438 785362 SGTC_328 k915-0120 63.5 µM -0.56441612727155 0.278013758923111 no 2422 0.286235482911248 3466 6624543 SGTC_1678 st019265 80.2 µM -0.564745924393641 0.277900755696857 no 2423 0.286123296342229 3522 5367020 SGTC_2394 5221648 200 µM -0.565529768187773 0.277632265799274 no 2424 0.285856741285256 3480 788586 SGTC_1153 4055-0057 267 µM -0.565815968376278 0.277534265283243 no 2425 0.285759445069754 3379 882706 SGTC_1444 4112-3581 28 µM -0.566631734986496 0.277255023714545 no 2426 0.285482204664162 3478 2877249 SGTC_1173 0443-0020 122 µM -0.568124411194489 0.276744428180654 no 2427 0.284975246559924 3416 5331295 SGTC_1291 0993-0025 5.79 µM -0.568484091777757 0.276621462173621 no 2428 0.284853152348573 3514 4353356 SGTC_1530 rhein 70.4 µM -0.569144477628601 0.27639576212243 no 2429 0.284629048199291 3478 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_635 k038-0028 24.7 µM -0.572110713054191 0.275383107317162 no 2430 0.283623485878087 3434 4035102 SGTC_2804 7954240 19.48 µM -0.57350455351698 0.274907889915589 no 2431 0.283151558431378 3486 828705 SGTC_1190 1486-1332 13 µM -0.574315377686201 0.274631632732748 no 2432 0.28287720248235 3447 4150046 SGTC_268 camptothecin 39.6153 µM -0.574878936251721 0.27443970249639 no 2433 0.282686588228729 3500 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3329 9141233 27.5565 µM -0.57536324718495 0.274274814405708 no 2434 0.282522827490447 3511 4909101 YNL103W MET4 SGTC_409 arachidonic acid 100 µM -0.575463388813251 0.27424072637578 no 2435 0.282488972152188 3452 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_506 n9-isopropylolomoucine 153 µM -0.57571550076642 0.274154917185867 no 2436 0.282403748150168 3496 6610355 SGTC_1863 st057641 20.1 µM -0.57683571626394 0.273773799481268 no 2437 0.282025219790072 3495 3921635 SGTC_35 0133-0054 64.071 µM -0.579308470917755 0.272933452007008 no 2438 0.28119052538399 3423 99677 SGTC_533 1222-0222 6.71 µM -0.57970742589801 0.272797990019421 no 2439 0.28105596738702 3535 3982874 SGTC_1169 aniline yellow 25.8 µM -0.580143466866894 0.272649973937025 no 2440 0.28090893676118 3439 6051 A DNA damaging agent. SGTC_2347 9049783 174.81 µM -0.580346104447873 0.272581201260558 no 2441 0.28084062113498 3501 6467988 YPL169C MEX67 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.581457818777537 0.272204052520817 no 2442 0.280465969570669 3437 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1066 ketoconazole 628 nM -0.581749495972345 0.272105144089816 no 2443 0.280367713429843 3523 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1667 st014849 34.6 µM -0.585014636159725 0.270999148320638 no 2444 0.279268937735869 3508 5348460 SGTC_2572 astragaloside iv 100 µM -0.585603269674491 0.270800000275729 no 2445 0.279071075314799 3502 45006101 An anti-inflammatory agent. SGTC_1259 0671-0132 43 µM -0.586675918857389 0.270437286726989 no 2446 0.278710691951556 3398 X1259 SGTC_2689 tacrolimus 100 µM -0.587366343235445 0.270203950005932 no 2447 0.278478846498557 3462 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_3090 9117696 49.47 µM -0.590023748194941 0.269306790553285 no 2448 0.277587364100828 3414 7923821 SGTC_3146 9095609 49.47 µM -0.592489141637283 0.268475793559488 no 2449 0.276761544874302 3468 17173999 SGTC_1365 1672-3266 55.4 µM -0.592669105969362 0.268415184469284 no 2450 0.276701310383023 3518 6415873 SGTC_2366 9070441 60.58 µM -0.592947202449085 0.268321539584327 no 2451 0.276608243462146 3458 6837235 SGTC_2686 alizarin 95.37 µM -0.594128016329413 0.267924101054649 no 2452 0.27621324684879 3436 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2730 imipramine 71.33 µM -0.594151568882411 0.267916176749195 no 2453 0.276205371049771 3538 3696 A tricyclic antidepressant. SGTC_2017 5132927 60.65 µM -0.594261054567571 0.267879341612411 no 2454 0.276168761295772 3439 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1004 4084-0029 199 µM -0.595922302241695 0.26732074806165 no 2455 0.275613566769777 3528 716894 YLR208W SEC13 SGTC_2241 6772625 37.8075 µM -0.595951274763794 0.267311011284773 no 2456 0.275603888927165 3485 2285411 SGTC_2010 4012422 159 µM -0.596790548603729 0.267029034756565 no 2457 0.275323614461539 3454 952393 SGTC_3134 9127454 49.47 µM -0.596938755120327 0.266979256416186 no 2458 0.275274135654196 3603 24262820 SGTC_917 harmaline 728.087 nM -0.598655900404681 0.26640285823853 no 2459 0.274701185319032 3473 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_572 0960-0087 17.7 µM -0.59883452315872 0.266342935693902 no 2460 0.274641619040697 3463 6796365 SGTC_1188 1403-0014 4.57 µM -0.600008840060818 0.265949157697534 no 2461 0.27425017203213 3506 9614867 SGTC_163 TUB2.036 7.546 µM -0.600156218282731 0.265899758912329 no 2462 0.274201064414601 3500 15992207 YJR013W GPI14 SGTC_1448 4255-0083 152 µM -0.600649378309822 0.265734493500799 no 2463 0.27403677108585 3567 5399660 SGTC_2708 st078559 56 µM -0.601680733826966 0.265389039021709 no 2464 0.273693338451073 3473 17250902 SGTC_2267 7931562 200 µM -0.602772801314165 0.265023497548429 no 2465 0.273329921481629 3428 934880 SGTC_1495 4469-0029 237 µM -0.603016382124248 0.264942000048244 no 2466 0.273248895547549 3520 793680 SGTC_1082 camptothecin 424.86 nM -0.603543249782285 0.264765763740605 no 2467 0.273073676378481 3431 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3160 9100216 49.47 µM -0.605205402319579 0.264210167542019 no 2468 0.272521263363916 3484 17191039 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.605786018262963 0.26401622910869 no 2469 0.272328427681137 3451 6708514 SGTC_555 4296-0685 37 µM -0.605876516060344 0.263986007399609 no 2470 0.272298377424042 3496 2908540 YHR072W ERG7 SGTC_198 3454-2873 16.191 µM -0.606959937094548 0.263624336258481 no 2471 0.271938749899729 3457 710957 SGTC_2591 skatole 100 µM -0.607404376998834 0.263476045037083 no 2472 0.271791292219186 3531 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2543 pimpinellin 60.67 µM -0.608670628429958 0.263053782866632 no 2473 0.271371389607227 3445 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_483 fpl-64176 144 µM -0.609582372316835 0.26274995412228 no 2474 0.271069245819271 3549 3423 SGTC_581 0958-0271 211 µM -0.611252162796889 0.262193980374523 no 2475 0.270516327541868 3498 4591145 SGTC_1864 st057645 30.4 µM -0.612147347686175 0.261896167833185 no 2476 0.270220136864341 3582 688666 SGTC_2292 7671323 168.05 µM -0.612293203353055 0.261847660613368 no 2477 0.270171892829828 3534 937504 SGTC_2104 5389443 200 µM -0.612700219750607 0.261712323542889 no 2478 0.270037288602259 3583 2244536 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.612983443582645 0.261618169934122 no 2479 0.269943643566378 3509 23665772 A membrane-active detergent. SGTC_1012 4112-3522 18 µM -0.613751897320949 0.261362796363218 no 2480 0.269689644176326 3546 3112398 SGTC_459 nigericin 15.3 µM -0.615450577992482 0.260798743211502 no 2481 0.269128599126798 3582 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1457 k015-0032 57.3 µM -0.616215926217482 0.260544811329662 no 2482 0.268876009263214 3548 4302660 SGTC_2544 sphondin 68.51 µM -0.616539832573515 0.260437382061767 no 2483 0.268769145469416 3564 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1126 isoteolin 1.0172 µM -0.618445554013448 0.259805778151304 no 2484 0.268140838605125 3539 133323 SGTC_269 exalamide 29 µM -0.61853727395561 0.259775399807439 no 2485 0.268110617652498 3502 3316 A derivative of salicylamide. SGTC_125 0133-0007 11.75 µM -0.619500339840923 0.259456535747707 no 2486 0.267793399052062 3607 26541 SGTC_1367 1812-0510 76.9 µM -0.620328691273816 0.259182436462863 no 2487 0.267520704599749 3504 1142582 YDR527W RBA50 SGTC_2576 guaiol 23.12 µM -0.621840891995079 0.25868243959414 no 2488 0.267023247386612 3541 227829 SGTC_2636 apigenin dimethyl ether 100 µM -0.622940413457736 0.258319205537799 no 2489 0.266661839679436 3571 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1040 k898-0338 155 µM -0.622985406834003 0.258304347314991 no 2490 0.266647055829596 3604 20969351 SGTC_1001 4048-4355 44.4 µM -0.624639215944278 0.257758515212959 no 2491 0.266103937640772 3553 21824233 SGTC_3017 9080681 49.47 µM -0.625686498636333 0.257413174233018 no 2492 0.265760295332016 3539 16451914 SGTC_1784 st039334 36.3 µM -0.625753174902854 0.257391195907919 no 2493 0.265738424631285 3639 3496984 SGTC_1103 duloxetine 36.1 µM -0.626018147430756 0.257303863337649 no 2494 0.265651519142974 3616 60835 A selective serotonin reuptake inhibitor. SGTC_297 0986-0032 24 µM -0.626703173702584 0.257078156214147 no 2495 0.265426911559313 3517 2847425 SGTC_3297 9117502 71.43 µM -0.626975831375206 0.256988347764155 no 2496 0.265337538914775 3551 7453720 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.627280684277508 0.25688795412374 no 2497 0.265237631299543 3532 75037 A free radical scavenger. SGTC_2897 9048598 12.99 µM -0.627659932942925 0.2567630890897 no 2498 0.265113369072331 3516 6467404 SGTC_1394 3474-0001 65.7 µM -0.628293756731149 0.25655447748017 no 2499 0.264905760389115 3474 5017666 YIL048W NEO1 SGTC_2921 7974240 10.71 µM -0.630112494995794 0.255956363228476 no 2500 0.264310492596922 3564 2979074 YDR527W RBA50 SGTC_97 0535-0701 19.132 µM -0.632209314705637 0.255267702504247 no 2501 0.263625055752144 3545 2832013 YGL099W LSG1 SGTC_842 0271-0008 11.1 µM -0.633238675621535 0.254929983242568 no 2502 0.263288896493428 3614 1221709 SGTC_1481 3346-2004 36 µM -0.634602613714716 0.254482854198575 no 2503 0.262843811535914 3580 2770522 SGTC_429 1112-0049 25.5 µM -0.635098081485828 0.25432053072174 no 2504 0.262682224117412 3516 2836170 SGTC_2938 9059746 27.26 µM -0.635216134155873 0.254281862713194 no 2505 0.262643730976325 3542 6471769 SGTC_1051 3253-3903 78 µM -0.635602099809226 0.254155461648376 no 2506 0.26251790026097 3545 5509239 SGTC_1707 st032323 6.317 µM -0.636191727058313 0.253962426470636 no 2507 0.262325732341199 3521 3132057 YMR211W DML1 SGTC_482 fipronil 114 µM -0.637007842344646 0.253695369476537 no 2508 0.262059867667295 3598 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1777 st045864 34.765 µM -0.637987320616155 0.253375050110892 no 2509 0.26174096692115 3582 4691462 SGTC_709 3807-1509 243 µM -0.638769541859521 0.253119392587482 no 2510 0.261486432631225 3619 1886677 YPL242C IQG1 SGTC_95 0471-0001 561.058 µM -0.639972526532973 0.252726479675726 no 2511 0.261095230358768 3524 4015405 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.64075827708085 0.252470015219954 no 2512 0.260839872251902 3559 688664 SGTC_2653 dihydrofissinolide 100 µM -0.641049140510424 0.252375113863356 no 2513 0.260745378234406 3587 6857746 SGTC_39 0986-0283 58.349 µM -0.644316604842703 0.251310316544052 no 2514 0.259685075125735 3631 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1039 k821-0043 94 µM -0.645688226418376 0.250864042991166 no 2515 0.259240643458472 3575 15992768 SGTC_860 0443-0016 25.1 µM -0.645886050852325 0.250799713068385 no 2516 0.259176577004258 3600 5337942 SGTC_2524 avocatin b 10.57 µM -0.647135812148921 0.250393508976713 no 2517 0.258772024679008 3531 6710748 SGTC_2671 danthron 100 µM -0.649289018503502 0.249694481144393 no 2518 0.258075791226055 3551 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1399 3562-5772 25 µM -0.650827725275768 0.249195583242345 no 2519 0.257578850353287 3552 23847490 SGTC_484 loperamide 105 µM -0.651244011221406 0.249060701206509 no 2520 0.257444492067647 3549 3955 An opioid-receptor agonist. SGTC_3167 9103034 49.47 µM -0.651469225074828 0.248987745196551 no 2521 0.257371818397036 3598 5127859 SGTC_576 1073-0113 22.7 µM -0.651859941101765 0.248861203222982 no 2522 0.257245764556564 3736 5439563 SGTC_866 0495-0101 262 µM -0.652116499697815 0.248778129706164 no 2523 0.257163010401222 3552 635694 SGTC_2313 7726885 200 µM -0.652673741078065 0.248597746161547 no 2524 0.256983317324427 3575 726423 SGTC_2303 7774051 200 µM -0.652674083590624 0.24859763530889 no 2525 0.256983206894832 3604 2953184 SGTC_1045 1348-1485 165 µM -0.652674658687822 0.248597449181314 no 2526 0.256983021477596 3640 6810614 SGTC_3333 9141820 12.094 µM -0.654946213689871 0.247862850390296 no 2527 0.256251192243969 3583 1939433 SGTC_2301 7769476 200 µM -0.655856709014038 0.247568730686526 no 2528 0.25595816233769 3593 977820 SGTC_2997 9067075 71.4286 µM -0.655873955000907 0.247563161469739 no 2529 0.25595261365098 3583 27209819 SGTC_1977 st070720 65.3 µM -0.658436303302772 0.246736450973657 no 2530 0.255128907130579 3603 682188 SGTC_2655 perillic acid 100 µM -0.660027990883594 0.246223657627801 no 2531 0.254617933492916 3590 5702197 An apoptosis inducer. SGTC_954 1189-0853 2.85 µM -0.660068822415655 0.246210510471475 no 2532 0.254604832550801 3599 2828194 SGTC_1199 1638-0010 4.46 µM -0.660871587105399 0.245952108445486 no 2533 0.254347334374425 3588 3111136 SGTC_380 3970-0968 6 µM -0.662500613782169 0.24542818844113 no 2534 0.253825220799079 3581 2891601 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.662511024295882 0.245424842189626 no 2535 0.253821885972372 3635 23847180 SGTC_1443 4112-3303 14 µM -0.662622789559268 0.245388919024687 no 2536 0.253786085366298 3616 704433 SGTC_2250 alverine citrate 130 µM -0.663102163985021 0.245234872382144 no 2537 0.253632562410644 3565 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2085 5307070 144.047 µM -0.664304083050334 0.244848865230378 no 2538 0.25324785414537 3579 2840351 SGTC_1614 st002383 48.6 µM -0.664552601456975 0.244769092119667 no 2539 0.253168347081761 3620 1947235 SGTC_1911 st060208 74.3 µM -0.664554745427242 0.244768403977286 no 2540 0.253167661230812 3624 688783 SGTC_1470 k295-0292 231 µM -0.664579713366163 0.244760390184936 no 2541 0.253159674118958 3640 5045612 SGTC_3277 9138724 49.47 µM -0.664977032160497 0.244632884438971 no 2542 0.253032591770737 3547 15943418 SGTC_2447 5741742 33.78 µM -0.665846433526337 0.244354004912803 no 2543 0.252754631010998 3653 1776504 SGTC_1680 diphenhydramine 100 µM -0.666096746364006 0.244273743367486 no 2544 0.252674632031982 3620 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_26 0302-0163 425.158 µM -0.666401481759697 0.24417605068903 no 2545 0.252577257824182 3625 3100915 SGTC_3192 9110362 49.47 µM -0.666919122230606 0.244010152775839 no 2546 0.252411897907562 3683 16649480 SGTC_3161 9100388 49.47 µM -0.668090584322829 0.243634937041359 no 2547 0.252037885874964 3660 25236368 SGTC_3006 9075424 71.4286 µM -0.669403462560451 0.243214796666128 no 2548 0.251619071722881 3608 7465181 SGTC_3185 9108267 49.47 µM -0.669440571297856 0.243202927018068 no 2549 0.251607239210847 3605 4910486 SGTC_941 3237-0776 460 µM -0.673056388410598 0.242047870435278 no 2550 0.250455708891011 3638 760008 SGTC_2929 9013348 24.6 µM -0.674490759476595 0.241590492521094 no 2551 0.249999679274407 3635 2995952 SGTC_594 1487-1584 10.8 µM -0.674780425301228 0.241498183762985 no 2552 0.249907639316915 3614 5013332 SGTC_670 4204-0025 119 µM -0.675788644833277 0.241177040558586 no 2553 0.249587422584045 3639 719039 SGTC_756 0508-1999 28.3 µM -0.676242028586619 0.241032702164027 no 2554 0.249443496192524 3615 6753853 SGTC_2052 5265182 7.135 µM -0.676646628676037 0.240903934118618 no 2555 0.249315093399446 3635 1239884 SGTC_1866 st057638 64 µM -0.676908129484491 0.240820728770674 no 2556 0.249232122907162 3633 688802 SGTC_867 0518-0118 155 µM -0.677343727281507 0.240682163286439 no 2557 0.249093946520287 3671 6848158 SGTC_2638 epoxomicin 18 µM -0.677754393488478 0.240551568396682 no 2558 0.248963716036294 3632 9915668 A protesome inhibitor. SGTC_2847 9005661 71.43 µM -0.679783324123943 0.239906920013728 no 2559 0.248320833552518 3555 2991449 SGTC_1247 0448-0043 5.84 µM -0.680657642816475 0.239629415129023 no 2560 0.248044071964481 3677 3089013 YGL099W LSG1 SGTC_2147 5545932 89.7195 µM -0.681147046946399 0.239474156940363 no 2561 0.247889225194136 3649 797404 SGTC_1958 st076513 41.9 µM -0.681482440113293 0.239367788798779 no 2562 0.247783137076144 3616 732122 YGL099W LSG1 SGTC_1112 tnp00069 1.16933 µM -0.681589093255709 0.239333969735993 no 2563 0.247749406731217 3685 145826 SGTC_955 1216-0110 33 µM -0.686736248763965 0.23770494443221 no 2564 0.246124474951795 3610 3619719 SGTC_3249 9135183 49.47 µM -0.687858067926316 0.237350708515126 no 2565 0.245771082342716 3678 4902779 SGTC_1660 st012960 28.1 µM -0.688008546982637 0.237303213926123 no 2566 0.245723699544197 3639 24207266 SGTC_3048 9093155 49.47 µM -0.689732977995864 0.236759317330715 no 2567 0.245181061579639 3623 25236002 SGTC_3162 9099653 49.47 µM -0.689750302238634 0.236753856634144 no 2568 0.245175613318294 3635 25237511 SGTC_603 3794-0023 45.9 µM -0.690194616908677 0.236613829879062 no 2569 0.24503590406615 3645 3802260 SGTC_2296 7971656 126.45 µM -0.690422705637254 0.236541964912438 no 2570 0.244964201025446 3699 666570 SGTC_1802 st050112 57.9 µM -0.690603747070592 0.236484931905198 no 2571 0.244907296030225 3662 4662563 SGTC_527 4476-4215 268 µM -0.691713510224843 0.236135491571563 no 2572 0.244558630459748 3649 4418754 SGTC_509 pifithrin 175 µM -0.692618132332985 0.235850856260086 no 2573 0.244274614059628 3693 4817 A p53 inhibitor. SGTC_1172 0370-0043 85 µM -0.692690886487774 0.235827972710133 no 2574 0.244251779792614 3684 376585 SGTC_1809 st050081 57.6 µM -0.693457651037327 0.23558687474485 no 2575 0.244011196764434 3715 5036894 SGTC_1084 voriconazole 435 nM -0.693466004327624 0.235584248923106 no 2576 0.24400857650765 3675 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_467 ro 31-8220 72.8 µM -0.694348413568433 0.235306958236228 no 2577 0.243731868235272 3622 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_157 1348-1695 65.819 µM -0.695623094715476 0.234906717282565 no 2578 0.243332449560031 3675 5380510 SGTC_105 0111-0055 734.78 µM -0.69565144899834 0.234897818515808 no 2579 0.243323568828354 3640 5179370 SGTC_1887 st057648 70.8 µM -0.697317726047749 0.234375197969848 no 2580 0.242801988590699 3654 688672 SGTC_2683 piperine 63.03 µM -0.697757061316876 0.234237509647322 no 2581 0.242664568156745 3649 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3140 9094243 49.47 µM -0.69780324304574 0.234223038826608 no 2582 0.242650125340618 3699 19291112 SGTC_2485 5633444 17.78 µM -0.698255064749631 0.234081488797921 no 2583 0.24250884773991 3668 5724239 SGTC_2028 5153890 36.43 µM -0.699148580237197 0.233801701224806 no 2584 0.242229590601774 3655 2830968 YPR165W RHO1 SGTC_2838 9002687 71.43 µM -0.699664488170338 0.233640238795662 no 2585 0.242068429413024 3673 6457060 SGTC_895 0964-0006 13.7 µM -0.699741940909827 0.233616003942052 no 2586 0.242044239466602 3646 6738897 SGTC_1243 0416-0003 5.65 µM -0.701087246013773 0.233195282299142 no 2587 0.241624284603622 3690 2141977 SGTC_921 1561-0023 372 µM -0.701102297074948 0.233190577712011 no 2588 0.241619588453613 3671 24050882 SGTC_2078 5212016 200 µM -0.702141471057485 0.232865885210434 no 2589 0.241295470910027 3606 1899708 SGTC_2721 ifenprodil 61.44 µM -0.702920253809261 0.232622717337644 no 2590 0.241052724146698 3680 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1615 st002656 86.5 µM -0.7032604314734 0.232516544249947 no 2591 0.24094673237431 3689 1584458 SGTC_2188 6126565 140.678 µM -0.703473154790648 0.232450164723143 no 2592 0.240880465417481 3635 874518 SGTC_2460 5552655 174.22 µM -0.704218703665872 0.232217602163304 no 2593 0.240648292459734 3658 5401989 SGTC_664 1222-0054 14.9 µM -0.704788360429947 0.232039993752675 no 2594 0.24047097656501 3674 6813991 SGTC_1321 1326-2144 215 µM -0.704876288632332 0.232012586109607 no 2595 0.240443613673712 3679 3513030 SGTC_700 3453-2283 142 µM -0.705331656341464 0.23187067464946 no 2596 0.240301932270014 3742 565664 SGTC_1833 st055984 71 µM -0.706485160889686 0.231511411238064 no 2597 0.239943238821843 3717 676288 SGTC_3138 9097216 49.47 µM -0.708163135689255 0.230989354047739 no 2598 0.239421977990958 3696 25237486 SGTC_2420 aureobasidin a 50 nM -0.708599845341294 0.230853591319013 no 2599 0.23928641615946 3733 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_650 1328-0195 38 µM -0.708706110730239 0.230820562658204 no 2600 0.239253435985911 3652 2780821 SGTC_632 0781-2353 4.65 µM -0.709829994200607 0.230471406700216 no 2601 0.238904783317724 3741 6811515 YHR007C ERG11 SGTC_99 0109-0120 622.8 µM -0.710354054581159 0.230308698272019 no 2602 0.238742303624805 3728 759414 SGTC_1881 5652484 16 µM -0.710526489784534 0.230255175243543 no 2603 0.238688855032027 3651 2255129 SGTC_1402 3909-7673 35.9 µM -0.710571819397677 0.230241106312184 no 2604 0.238674805600322 3689 5328014 SGTC_2814 7977482 42.97 µM -0.711076226126724 0.23008458627111 no 2605 0.238518500634099 3748 6456762 SGTC_3153 9100258 49.47 µM -0.711387117220871 0.229988144805096 no 2606 0.23842218998544 3651 25236848 SGTC_382 3229-0966 23.2 µM -0.712227665617323 0.229727511755419 no 2607 0.238161903965576 3702 5722370 SGTC_2891 9063876 19.48 µM -0.712781873347247 0.229555756315582 no 2608 0.237990372020581 3679 6472478 SGTC_1825 st052143 62.6 µM -0.716664190097065 0.228354600415834 no 2609 0.236790663378004 3715 674173 SGTC_3187 9109394 49.47 µM -0.716698399098991 0.228344032162935 no 2610 0.236780106957521 3655 17098090 SGTC_72 0744-0168 198.391 µM -0.718329942249241 0.227840315677991 no 2611 0.236276936152877 3633 677577 SGTC_88 0180-0332 8.668 µM -0.719631177486179 0.227439025820905 no 2612 0.235876055329508 3762 3101745 SGTC_3005 9076496 71.4286 µM -0.719905509188081 0.227354475104422 no 2613 0.235791587884298 3723 21368410 SGTC_3066 9117245 49.47 µM -0.720116608372498 0.227289425096646 no 2614 0.235726601251799 3770 17176980 SGTC_1973 st070275 50.2 µM -0.720926365683455 0.22703999646853 no 2615 0.235477410061666 3635 17118334 SGTC_145 3737-0113 38.366 µM -0.722813781027164 0.226459217585652 no 2616 0.234897149745741 3733 6849351 SGTC_2753 fluvastatin 17.09 µM -0.723252971765849 0.226324194081786 no 2617 0.234762239915052 3732 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2046 4110841 106 µM -0.723752145869163 0.226170784699099 no 2618 0.234608956525894 3712 44119630 YMR134W ERG29 SGTC_2072 5231554 129 µM -0.724197017767615 0.226034113350922 no 2619 0.234472394592341 3767 789545 SGTC_966 1300-0360 30.2 µM -0.725064600260118 0.225767713284787 no 2620 0.234206200118388 3713 70588 SGTC_1349 flufenamic acid 69 µM -0.725178298827647 0.225732814145435 no 2621 0.234171327159559 3684 3371 A non-steroidal anti-inflammatory. SGTC_2971 9092186 9.93 µM -0.725944813012135 0.225497616556558 no 2622 0.233936301458786 3715 25236400 SGTC_3056 9094900 49.47 µM -0.727249635276929 0.225097563464397 no 2623 0.233536522502467 3692 25236784 SGTC_2040 5100729 123 µM -0.727610502749807 0.224986994021882 no 2624 0.233426024770962 3740 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_736 0958-0254 92.6 µM -0.727648044757115 0.224975492955343 no 2625 0.233414531062589 3776 6812352 SGTC_1673 st016611 27.3 µM -0.727863807850368 0.22490939997547 no 2626 0.233348479998776 3730 5226799 SGTC_303 1348-1668 34.2 µM -0.729322684794602 0.224462802797943 no 2627 0.232902149561556 3738 5380509 SGTC_207 4185-0010 4.486 µM -0.731170744201343 0.223897790745354 no 2628 0.232337433721573 3781 3761753 SGTC_2475 5812728 15.03 µM -0.732946527907636 0.223355637981315 no 2629 0.231795521729695 3720 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1757 st041620 31.8375 µM -0.733622683137144 0.223149402044106 no 2630 0.231589366179729 3771 5289815 SGTC_973 1325-0077 65.9 µM -0.733876014929202 0.223072160556705 no 2631 0.231512153207839 3757 2835149 SGTC_574 1315-0397 40 µM -0.734000651299661 0.223034164208894 no 2632 0.231474170568737 3744 6794277 SGTC_2048 5246248 200 µM -0.735456405852891 0.222590639357834 no 2633 0.23103079018339 3709 677046 SGTC_1460 k062-0059 9.15 µM -0.735484454964558 0.222582098573369 no 2634 0.231022251899384 3649 1373085 SGTC_3290 9121031 71.43 µM -0.73641303439206 0.222299457262785 no 2635 0.230739687328504 3731 17014854 SGTC_2428 5615643 7.78 µM -0.737520990161051 0.221962485395946 no 2636 0.23040279169091 3757 2253075 SGTC_797 k781-0471 270 µM -0.739051297211609 0.221497540275217 no 2637 0.22993792443749 3731 23738129 SGTC_786 4544-0069 423 µM -0.74007988273681 0.22118534367871 no 2638 0.229625762314818 3793 748821 YLR208W SEC13 SGTC_2430 5571206 200 µM -0.741721170248307 0.22068770129053 no 2639 0.229128145216758 3779 1731771 SGTC_2054 5233173 129 µM -0.745634019528802 0.219503906262694 no 2640 0.227944263270478 3770 6889 SGTC_3289 9119912 71.43 µM -0.746928660303599 0.219113029698209 no 2641 0.227553312338529 3754 17014829 SGTC_3307 9126885 69.2785 µM -0.747306974841321 0.218998884982604 no 2642 0.227439141614485 3748 24824909 SGTC_1669 st015249 58.4 µM -0.749949726460544 0.218202470869057 no 2643 0.226642491906856 3828 722793 SGTC_1369 1866-0067 208 µM -0.752020140819291 0.217579702747189 no 2644 0.226019473388287 3760 3531355 SGTC_512 prima-1 270 µM -0.752053957401165 0.217569539445246 no 2645 0.226009305516998 3762 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1493 4348-0038 111 µM -0.752542838032488 0.217422640915068 no 2646 0.225862339207295 3784 800424 SGTC_3258 9138477 49.47 µM -0.753174365727731 0.217232964677433 no 2647 0.225672570648226 3802 4970355 SGTC_1749 st037932 54.2 µM -0.756097514756556 0.216356257235639 no 2648 0.224795365960004 3789 594497 SGTC_2352 9027995 87.8 µM -0.756866188438818 0.216126058059206 no 2649 0.224565016948648 3737 2997347 SGTC_865 0488-0499 301 µM -0.758206003980266 0.215725154992437 no 2650 0.224163833743275 3740 9634651 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.758302638816864 0.215696256344442 no 2651 0.224134913958298 3823 6708561 SGTC_1534 6-azauridine 81.6 µM -0.759143234502732 0.215444970892874 no 2652 0.223883439356552 3797 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1384 3089-0840 101 µM -0.759551824773698 0.215322889356706 no 2653 0.22376126245589 3728 1069836 SGTC_2925 9010536 32.5 µM -0.759632052220674 0.215298923139305 no 2654 0.223737277250502 3751 2994177 SGTC_2825 7998094 58.44 µM -0.760761001984291 0.214961837961774 no 2655 0.223399915725011 3762 2987815 SGTC_2468 5987765 72.9 µM -0.761152625678983 0.214844977435612 no 2656 0.223282955345118 3807 26772094 SGTC_1455 4262-0120 131 µM -0.763567610481705 0.214125161816473 no 2657 0.222562478582337 3890 1529587 SGTC_1282 0886-0010 32.4 µM -0.764817116361821 0.213753282945882 no 2658 0.2221902270039 3847 2836211 YNL267W PIK1 SGTC_1854 st056233 32.9 µM -0.765938332438473 0.213419906223844 no 2659 0.221856498075255 3700 5393174 SGTC_2318 6029776 164 µM -0.76628155743336 0.213317914058525 no 2660 0.221754394735549 3769 818325 SGTC_2513 baicalein 25.65 µM -0.767635128577958 0.212915966242806 no 2661 0.221351993151006 3787 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_18 0111-0177 500 nM -0.767771423093621 0.21287551760468 no 2662 0.221311497466734 3854 721752 SGTC_773 4358-1457 44.6 µM -0.768032816309126 0.212797955502857 no 2663 0.221233844443783 3770 1186886 SGTC_1773 st048542 73.5835 µM -0.768193695980739 0.212750226561532 no 2664 0.221186059090136 3738 3237138 SGTC_1769 st044406 64.4 µM -0.76839951001288 0.212689175841659 no 2665 0.221124935698457 3784 670903 SGTC_1691 st019933 84.6 µM -0.769741710078354 0.212291289313561 no 2666 0.220726561396298 3744 6176082 SGTC_2560 caryophyllene 100 µM -0.77000897851966 0.212212111282695 no 2667 0.220647283370016 3843 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2949 9072542 2.23 µM -0.770791466234734 0.211980399290872 no 2668 0.220415273148765 3858 16457352 SGTC_2168 5727979 200 µM -0.772379739826124 0.21151053147654 no 2669 0.219944774933099 3730 695210 SGTC_1631 benzylvanillin 81.9 µM -0.774622518850449 0.210848077283192 no 2670 0.219281373427641 3860 75506 SGTC_2427 5545055 42.75 µM -0.774692106451871 0.210827542532997 no 2671 0.219260808215821 3770 5372858 SGTC_1081 sertraline 6 µM -0.774821347207197 0.21078940772154 no 2672 0.219222616659252 3796 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_3211 9128781 49.47 µM -0.775195584708249 0.210679005031388 no 2673 0.219112048403571 3846 17194361 SGTC_2084 5306078 60.6385 µM -0.776157203301426 0.210395476418889 no 2674 0.218828085838427 3739 679340 SGTC_2258 7960471 200 µM -0.777157843105019 0.210100680547144 no 2675 0.218532825380789 3799 2974708 SGTC_1093 fluphenazine 7.97 µM -0.777909360194704 0.209879437709043 no 2676 0.218311224892943 3823 6602611 An atypical antipsychotic. SGTC_1819 st053448 58.6 µM -0.779657117387113 0.209365436669426 no 2677 0.217796363156947 3737 2857616 SGTC_21 0849-0113 22.993 µM -0.780094596301372 0.209236893725573 no 2678 0.217667598445551 3762 1560156 SGTC_2756 carbadox 75.1 µM -0.780411482200519 0.209143813237565 no 2679 0.217574355739888 3824 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_54 0159-0055 9 µM -0.782904347474687 0.208412422096061 no 2680 0.216841642172062 3805 3319099 SGTC_552 k242-0005 476 µM -0.783181967900245 0.208331063450017 no 2681 0.21676013117233 3863 4088318 SGTC_1873 rapamycin 2 nM -0.784279497371954 0.208009608099437 no 2682 0.216438063555107 3786 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_503 tyrphostin 8 294 µM -0.785939413960893 0.207523991921877 no 2683 0.215951491195061 3758 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_265 mycophenolic acid 32.932 µM -0.786225600946856 0.207440334382078 no 2684 0.215867665129376 3876 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1295 1013-0063 9.78 µM -0.786646770281362 0.207317255366604 no 2685 0.215744336139454 3801 6826038 SGTC_2090 5301565 104.445 µM -0.78717007998182 0.207164387873408 no 2686 0.215591154794912 3818 2056344 SGTC_2980 9014342 25.29 µM -0.788392357231072 0.206807600124376 no 2687 0.215233619953983 3883 2996599 SGTC_2399 5884133 200 µM -0.788511023381447 0.206772980370647 no 2688 0.215198926621397 3831 722445 SGTC_1596 piperlongumine 63 µM -0.788682187309661 0.206723050919006 no 2689 0.215148890713522 3818 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_984 1492-0255 2.91 µM -0.788689394348612 0.206720948743055 no 2690 0.215146784046667 3779 1585198 SGTC_1765 st044815 90.4 µM -0.789074236433668 0.206608714955352 no 2691 0.215034309461488 3864 645695 SGTC_1428 4049-0204 61.7 µM -0.789230337701818 0.206563200503469 no 2692 0.214988696781318 3863 X1428 SGTC_3309 9129340 25.759 µM -0.791230638626297 0.205980498513179 no 2693 0.214404707748963 3862 17158987 SGTC_448 monastrol 171 µM -0.792167836178588 0.20570782188986 no 2694 0.214131410040886 3739 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2218 6965428 192.983 µM -0.792852458719573 0.205508767170297 no 2695 0.213931894338097 3756 675684 SGTC_972 1319-0219 195 µM -0.793696993051167 0.205263375553058 no 2696 0.213685925599497 3799 23903702 SGTC_2789 5281112 71.43 µM -0.794081814991797 0.205151617750223 no 2697 0.213573901725749 3847 765948 SGTC_2523 spermine 47.74 µM -0.794297634654972 0.20508895645805 no 2698 0.213511090364242 3814 1103 A DNA binding polyamine. SGTC_2626 ethyl orsellinate 100 µM -0.79445339361829 0.205043740316164 no 2699 0.213465765537091 3835 75653 A natural product. SGTC_2009 4012297 12.05 µM -0.795959539262644 0.204606818612991 no 2700 0.213027776498948 3845 45595307 SGTC_5 0352-0601 109.883 µM -0.796709675691272 0.20438941639591 no 2701 0.212809831627071 3741 762456 SGTC_1118 chelidonine 707.474 nM -0.797583196391185 0.204136428704098 no 2702 0.212556202755767 3806 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1415 3966-0071 78.1 µM -0.79773884928934 0.204091368343091 no 2703 0.212511027096538 3776 2893185 SGTC_1737 st035557 69.7 µM -0.797998112801792 0.204016326631694 no 2704 0.212435792636113 3729 5716916 SGTC_1389 3405-0187 19 µM -0.798321641903133 0.203922706829017 no 2705 0.212341931075432 3790 799890 SGTC_42 0133-0086 60.653 µM -0.799718078415066 0.203518913009844 no 2706 0.211937078094552 3740 162923 Model of phenazepam hydroxylation. SGTC_1294 1000-1494 117 µM -0.801769392873871 0.202926620175423 no 2707 0.211343183291246 3822 712797 YDL207W GLE1 SGTC_314 1671-0008 2.74 µM -0.801882011646885 0.202894132674449 no 2708 0.21131060625394 3755 3913060 SGTC_958 1222-0007 33 µM -0.803249740845466 0.202499827448976 no 2709 0.210915200457415 3911 7312461 SGTC_1032 k061-1018 98.7 µM -0.804391651872228 0.202170974949169 no 2710 0.210585410463837 3972 4005393 SGTC_1224 0823-0416 294 µM -0.805892368407375 0.201739278305467 no 2711 0.210152455995432 3914 3598164 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.807425343439039 0.201298872642942 no 2712 0.20971073530105 3833 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2919 7978188 46.38 µM -0.810172491251845 0.200511092800896 no 2713 0.208920522713715 3804 2980291 SGTC_927 2425-1185 123 µM -0.811612073912811 0.20009901438827 no 2714 0.208507130495982 3818 730375 SGTC_1867 st057372 64 µM -0.813919502878869 0.199439579128498 no 2715 0.207845533594672 3837 688837 SGTC_2150 5556613 200 µM -0.814170731944358 0.199367859963355 no 2716 0.207773574928459 3853 743190 SGTC_887 0885-0007 9.62 µM -0.814687677444727 0.199220334735224 no 2717 0.207625554328629 3947 5719458 SGTC_2597 laccaic acid a 100 µM -0.815395279274788 0.199018506881365 no 2718 0.207423042823043 3868 5491415 A textile dye. SGTC_2146 5545642 200 µM -0.815530478761368 0.198979958226398 no 2719 0.207384362811108 3830 825326 SGTC_1120 ficusin 1.78878 µM -0.815898547423948 0.1988750357189 no 2720 0.207279081503759 3956 6199 A DNA cross-linker. SGTC_1850 st056238 17 µM -0.816900796399311 0.198589501383843 no 2721 0.206992561323787 3865 5393177 SGTC_1054 3429-0080 167 µM -0.820967273173319 0.197433527285951 no 2722 0.20583245491773 3871 1162877 SGTC_2787 5284540 71.43 µM -0.82161041557804 0.197251075085927 no 2723 0.205649329740571 3903 736958 SGTC_903 1134-0042 114 µM -0.822421855152701 0.197021024473378 no 2724 0.20541842248996 3858 701009 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.823875710470381 0.196609249419137 no 2725 0.205005091530856 3844 2333 A French combination drug. SGTC_3089 9117425 49.47 µM -0.824115905350381 0.196541269306126 no 2726 0.204936851762124 3836 9401657 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.824240086791884 0.196506128978418 no 2727 0.204901576902579 3845 4620898 SGTC_1983 st071813 46.9 µM -0.825030974686082 0.19628241628775 no 2728 0.204677002782213 3946 11838595 SGTC_3127 9126946 49.47 µM -0.82816629580958 0.195397071273936 no 2729 0.203788164272875 3867 27243249 SGTC_1594 piperine 70.1 µM -0.828582424529562 0.195279748385803 no 2730 0.203670368302926 3849 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_968 1309-0633 340 µM -0.832334818984925 0.194223736596611 no 2731 0.202609991116434 3909 3761976 SGTC_352 k048-0007 5.11 µM -0.832911324310493 0.194061803243941 no 2732 0.202447371236858 3897 6811911 SGTC_2957 9076800 11.52 µM -0.834083032072011 0.193732938319682 no 2733 0.202117098012298 3858 16459615 SGTC_1981 st071826 47 µM -0.834570520203011 0.193596214465064 no 2734 0.201979783113094 3913 11838600 SGTC_3000 9075062 71.4286 µM -0.835833423479175 0.193242286802813 no 2735 0.201624310283853 3852 17057871 SGTC_1791 st048313 56.1 µM -0.836099136110872 0.193167871360535 no 2736 0.201549567172795 3845 1204976 SGTC_2974 9094440 9.66 µM -0.841092701053035 0.191772629719299 no 2737 0.200148001887343 3947 25236134 SGTC_2777 climbazole 1.536 µM -0.842563814587015 0.191362768568836 no 2738 0.199736217890726 3821 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1871 st057448 67.3 µM -0.843276846469602 0.191164306866352 no 2739 0.199536814421763 3926 691747 SGTC_2799 7812892 81.82 µM -0.843760911985696 0.191029646452212 no 2740 0.199401511020227 3912 20205235 SGTC_1806 st050005 60.3 µM -0.847301113416302 0.190046580310677 no 2741 0.198413653104892 3915 5194765 SGTC_3067 9117431 49.47 µM -0.848349845807082 0.189755959510967 no 2742 0.198121582696178 3945 17150885 SGTC_3054 9094397 49.47 µM -0.848726716114381 0.189651589412616 no 2743 0.198016688312542 3916 2598354 SGTC_1805 st050013 60.3 µM -0.850139531838351 0.189260640010583 no 2744 0.197623757680685 3851 4037144 SGTC_965 1291-5240 308 µM -0.851327373898659 0.188932328767504 no 2745 0.197293761430323 3899 2834598 SGTC_3243 9134147 49.47 µM -0.851399129844308 0.188912507170368 no 2746 0.197273837481018 3947 24282180 SGTC_717 1532-0246 73.2 µM -0.851497012654129 0.188885470450916 no 2747 0.197246661038813 3908 9561992 SGTC_2481 5478948 45.16 µM -0.854340083182926 0.188101211798611 no 2748 0.196458292026849 3963 77792 SGTC_1778 st046819 58.9 µM -0.854374410455615 0.188091754944996 no 2749 0.196448784930779 3955 671715 SGTC_2681 menadione 3.18 µM -0.854625040985618 0.188022717390638 no 2750 0.19637938010241 3932 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_858 0438-0351 2.77 µM -0.854820336137119 0.187968933114479 no 2751 0.19632530910008 3901 2799119 SGTC_1251 0490-5699 265 µM -0.858349164717965 0.186998730914453 no 2752 0.195349844510755 3942 3883818 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.859690217519348 0.186630841006239 no 2753 0.194979914329164 3977 5393153 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.860195805359227 0.186492259910465 no 2754 0.194840558265871 3933 1377 SGTC_2240 6690706 185.951 µM -0.862316743310536 0.185911607776184 no 2755 0.194256620779602 3786 805876 SGTC_248 streptozotocin 5.23457 mM -0.86272073858933 0.185801132669962 no 2756 0.194145513594433 3911 5300 DNA alkylating agent. SGTC_1049 3226-0134 66 µM -0.863110357755319 0.185694627383742 no 2757 0.194038396817975 3944 5702385 SGTC_1227 3909-8010 46.6 µM -0.865712211827168 0.184984362669276 no 2758 0.193324000743078 3922 15982272 SGTC_3206 9114350 49.47 µM -0.866311790604531 0.184820926836976 no 2759 0.193159601078742 3840 17087243 SGTC_2152 5568786 200 µM -0.86633860754965 0.184813619053079 no 2760 0.193152250083142 3878 5399883 SGTC_2889 9059656 51.95 µM -0.867256440447049 0.184563612169555 no 2761 0.192900758925778 4022 3949838 SGTC_1635 st007035 42.4 µM -0.867790081129595 0.184418351463583 no 2762 0.192754630495686 3908 3716403 SGTC_3088 9117578 49.47 µM -0.867895539715904 0.184389653321365 no 2763 0.192725760460169 3964 678341 SGTC_2177 5811945 192 µM -0.868306890045781 0.184277740293549 no 2764 0.19261317564604 3971 5343475 SGTC_1319 1306-0155 43.7 µM -0.870456805483002 0.183693516764089 no 2765 0.19202540735347 3959 3122360 SGTC_739 1486-1183 203 µM -0.871464560953993 0.183420064394674 no 2766 0.191750273964292 3904 4346692 SGTC_2249 haloperidol 116.36 µM -0.872927772822743 0.183023476864374 no 2767 0.191351223623142 3915 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2193 5925765 200 µM -0.874236474376712 0.182669221280595 no 2768 0.1909947431976 3917 877370 SGTC_3200 9114385 49.47 µM -0.876888891099919 0.181952546486264 no 2769 0.190273495325814 3992 17018030 YLR208W SEC13 SGTC_1098 clofazimine 15.1 µM -0.878483922553963 0.181522421716965 no 2770 0.189840579434168 4012 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_411 enrofloxacin 100 µM -0.879549440581198 0.181235443265783 no 2771 0.189551719283509 4044 71188 A bacterial gyrase inhibitor. SGTC_2115 tiliquinol 12.7705 µM -0.884667802434128 0.179860867118137 no 2772 0.18816791303744 3935 71208 A bioactive hydroxyquinoline. SGTC_2988 9073640 71.4286 µM -0.886064990692044 0.179486781967565 no 2773 0.187791253487076 4009 9102229 SGTC_3110 9122132 49.47 µM -0.886214841455173 0.179446689773524 no 2774 0.187750883792164 4058 918317 SGTC_1921 5740136 50 µM -0.886831422920079 0.179281784202223 no 2775 0.187584833569911 3856 1774243 SGTC_2455 5377712 9.75 µM -0.888900602188379 0.178729076161623 no 2776 0.187028250896206 3965 2243908 SGTC_2333 9017922 200 µM -0.889473369939778 0.178576271298896 no 2777 0.186874364440483 4024 3163164 SGTC_1698 5-fluorocytosine 1.055 µM -0.889834912835466 0.178479860068499 no 2778 0.18677726846621 3988 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1915 st067105 30.6 µM -0.891684555965234 0.177987136066048 no 2779 0.186281016903133 3932 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2570 licareol 100 µM -0.892396034386049 0.177797834903414 no 2780 0.186090347966834 3983 443158 SGTC_577 r071-0003 38.6 µM -0.893532859309709 0.177495626634467 no 2781 0.185785941702469 3992 4568517 YMR134W ERG29 SGTC_2507 purpurin 79.67 µM -0.894265683140116 0.177300988118709 no 2782 0.185589878152494 3957 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_3158 9100007 49.47 µM -0.895232713573189 0.177044350526072 no 2783 0.185331350318897 3982 19297233 SGTC_591 4299-0174 154 µM -0.897280790146901 0.176501592382168 no 2784 0.184784552167131 3941 5509088 SGTC_2282 7944268 200 µM -0.900975629364154 0.175525092991129 no 2785 0.183800638744673 3981 2970414 SGTC_1183 1254-0324 198 µM -0.901114427554218 0.175488477234026 no 2786 0.183763741333042 4056 5799357 SGTC_1091 telmisartan 47.6 µM -0.901312530191487 0.175436225011239 no 2787 0.183711086719274 4034 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1752 st044819 83.042 µM -0.902148815624571 0.175215752243541 no 2788 0.183488910168389 3985 441209 YML126C ERG13 SGTC_1366 1683-0113 21.9 µM -0.902983987257296 0.17499574855805 no 2789 0.183267196745781 3974 708623 SGTC_964 1287-0107 19.4 µM -0.904134519297347 0.174692958760873 no 2790 0.182962038172935 4008 51516812 YPR165W RHO1 SGTC_173 1273-0061 2.693 µM -0.90672565137343 0.174012259817499 no 2791 0.182275947530464 3972 2847414 YPL266W DIM1 SGTC_2521 angolensin 13.4 µM -0.907609647763744 0.173780417357122 no 2792 0.18204224761774 4056 821428 A flavenoid. SGTC_3109 9122853 49.47 µM -0.907745021855279 0.173744930651248 no 2793 0.182006475656206 4033 1234709 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.907775375406357 0.173736974462034 no 2794 0.181998455477593 3977 5106787 A p450 inhibitor. SGTC_1142 3253-1408 9.78 µM -0.908405383665454 0.173571890761154 no 2795 0.181832041200563 3935 256655 SGTC_3283 9109332 35.8195 µM -0.908451261402715 0.173559873125987 no 2796 0.181819926490395 3819 17027281 SGTC_2363 9053361 176 µM -0.908532396737921 0.173538621088605 no 2797 0.181798502714456 4057 6469797 YMR079W SEC14 SGTC_2915 7971052 15.16 µM -0.908779936996578 0.173473792312725 no 2798 0.181733149496445 3865 5741558 SGTC_2508 celastrol 40.54 µM -0.908966287328938 0.173424998850826 no 2799 0.18168396075775 3916 122724 Celastrol is a natural product and antioxidant. SGTC_1937 st074714 47.2 µM -0.909862287558809 0.173190514597767 no 2800 0.18144757029112 3936 17250970 SGTC_1999 st074831 12.5 µM -0.910216565193095 0.173097855474153 no 2801 0.181354154867146 3936 17112523 SGTC_2178 5812956 200 µM -0.91211574756553 0.172601674564719 no 2802 0.180853894698066 3941 5403383 SGTC_3209 9113616 49.47 µM -0.914257232840505 0.172043278477857 no 2803 0.180290848561156 4031 16649353 SGTC_400 oxethazaine 37.5 µM -0.919056580087106 0.170796033672645 no 2804 0.179032989283859 4009 4621 A local anesthetic. SGTC_1934 st074720 32.6 µM -0.920091129912829 0.170527936934077 no 2805 0.178762569614672 3939 17250992 SGTC_1719 st032227 49.2 µM -0.921653730554503 0.170123510491635 no 2806 0.178354611207844 3999 3125804 SGTC_228 caffeine 993.056 µM -0.922443429138786 0.169919357666684 no 2807 0.178148662735165 3990 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2453 5731132 22.18 µM -0.927538112421981 0.168606057840449 no 2808 0.176823606566365 4049 1362040 SGTC_1782 st039423 80.636 µM -0.928249407536934 0.168423221702839 no 2809 0.176639105459468 4034 2068169 SGTC_3046 9092212 49.47 µM -0.928601993208157 0.168332637963423 no 2810 0.176547694264228 4052 25236637 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.931978312752854 0.167466805683614 no 2811 0.175673866734638 4052 279621 SGTC_477 mead ethanolamide 10 µM -0.932410252193724 0.167356245381652 no 2812 0.175562274242729 3905 16061185 SGTC_1178 0988-0033 191 µM -0.935265972971366 0.166626471806231 no 2813 0.174825623297122 4063 5392207 SGTC_218 alverine citrate 93.75 µM -0.936149999859657 0.166400977471672 no 2814 0.174597981296184 4050 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1388 3346-4487 254 µM -0.936422434092677 0.166331525682595 no 2815 0.17452786587455 4074 3345614 SGTC_902 1120-0002 2.07 µM -0.936437123368884 0.166327781470341 no 2816 0.174524085856369 3993 3280475 SGTC_3145 9085516 49.47 µM -0.938687613026138 0.165754787545698 no 2817 0.173945577529109 4076 25236195 SGTC_1438 4092-1045 4 µM -0.940333066219764 0.165336649715409 no 2818 0.17352337178634 4002 1351342 SGTC_3320 9137005 35.139 µM -0.942676261154587 0.164742382833398 no 2819 0.172923259633707 4040 4908713 SGTC_12 0849-0099 9.267 µM -0.943897839497632 0.164433122960467 no 2820 0.172610928092503 3908 6071388 SGTC_3065 9113888 49.47 µM -0.944058754846225 0.164392413028591 no 2821 0.172569812295807 4101 16648368 SGTC_2200 6600604 21.907 µM -0.944397377386467 0.164306766344629 no 2822 0.172483310585829 3992 2904777 SGTC_1573 oleylamine 1.06 µM -0.94551119117304 0.164025257221913 no 2823 0.172198980052656 4023 5356789 An amine of the fatty acid oleic acid. SGTC_1935 st074532 41.6 µM -0.945519053136136 0.164023271275123 no 2824 0.172196974141546 4014 2829742 SGTC_1617 st002906 78 µM -0.947017248924249 0.163645108908696 no 2825 0.171814994770214 4021 5150859 SGTC_1130 3454-2858 15.9 µM -0.94709269032425 0.163626081586853 no 2826 0.171795774583752 4075 715628 YIL048W NEO1 SGTC_3150 9097574 49.47 µM -0.949228787308006 0.163087925764875 no 2827 0.171252131651012 4073 17217476 SGTC_1722 st034304 3.6505 µM -0.950427801247589 0.162786357856638 no 2828 0.170947461613247 4026 4036148 YLR033W RSC58 SGTC_828 2074-0507 139 µM -0.951131391366164 0.162609564563316 no 2829 0.17076884056495 4119 X828 SGTC_1768 st044301 37.178 µM -0.955905946026951 0.161413148637362 no 2830 0.169559877332542 4047 3931349 SGTC_3011 9081274 71.4286 µM -0.956475329542533 0.161270855638693 no 2831 0.169416071296212 4039 6625322 SGTC_1163 k060-0048 49.9 µM -0.956938897927113 0.161155067041643 no 2832 0.169299048222219 4033 6809982 SGTC_1913 st060213 96.1 µM -0.957195858248872 0.161090907703767 no 2833 0.169234203587969 4092 688959 SGTC_1253 0550-0034 176 µM -0.959366027869185 0.160549712141058 no 2834 0.168687191512839 4075 5969915 SGTC_691 1548-0686 185 µM -0.960026498597804 0.160385240369646 no 2835 0.168520939329469 4030 46495133 SGTC_2173 5763948 167 µM -0.960159726743166 0.16035207697363 no 2836 0.168487416217464 4023 2867177 SGTC_2329 6138490 200 µM -0.960631987725563 0.160234556996513 no 2837 0.168368619577148 4171 720019 SGTC_1293 1000-1278 195 µM -0.963239301540983 0.15958675259174 no 2838 0.167713723125352 4104 678847 SGTC_652 0437-0092 114 µM -0.963447520549415 0.159535093209709 no 2839 0.167661494190241 3986 3091274 SGTC_2718 lomofungin 53.02 µM -0.964823350001731 0.159194023437283 no 2840 0.167316649218511 4031 5351222 A RNA synthesis inhibitor. SGTC_2792 7535235 81.82 µM -0.965727996265771 0.158970020994672 no 2841 0.167090153305485 4057 1281891 SGTC_1969 st069479 40.1 µM -0.966151651702009 0.15886518932115 no 2842 0.16698415087012 4066 3895485 SGTC_1145 3546-0597 10.2 µM -0.9674859286588 0.158535324483495 no 2843 0.166650586121885 4023 875334 SGTC_2800 7887935 81.82 µM -0.968991664497369 0.158163610829807 no 2844 0.166274674050152 4074 2961002 SGTC_3091 9116372 49.47 µM -0.969199629338203 0.158112316558568 no 2845 0.166222797995385 4136 17169793 SGTC_2883 9059145 45.46 µM -0.97050207142312 0.157791319182686 no 2846 0.165898146451432 4027 16476510 SGTC_1525 8-methoxypsoralen 92.5 µM -0.972051520326759 0.157410002846791 no 2847 0.165512459221953 4129 4114 Related to psoralen; DNA damaging agent. SGTC_2727 riluzole 51.77 µM -0.972157429140822 0.157383961028399 no 2848 0.165486117702229 4075 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_387 norethindrone acetate 66.7 µM -0.974819449452767 0.156730329563596 no 2849 0.164824913838207 4064 541197 SGTC_2630 antimycin a 100 µM -0.975790217931515 0.156492412639549 no 2850 0.164584216638796 4016 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1221 2958-7315 257 µM -0.976610651812199 0.156291525386623 no 2851 0.164380971842817 4091 4562705 SGTC_1938 st074717 56.4 µM -0.979492356161268 0.155587272694348 no 2852 0.163668381810354 3942 17250979 SGTC_2788 5282734 71.43 µM -0.981312827172212 0.155143452769258 no 2853 0.163219249561894 4163 743706 SGTC_1287 0971-0001 34.6 µM -0.981588625411411 0.155076287786734 no 2854 0.163151276717137 4053 4665869 SGTC_118 0083-0097 135.343 µM -0.981965166879966 0.154984619868871 no 2855 0.163058504546161 4088 5207356 SGTC_2483 5729050 27.16 µM -0.98233070641083 0.154895664578702 no 2856 0.162968475836941 4078 2865180 SGTC_449 xestospongin c 11.1929 µM -0.982832446537733 0.154773619332863 no 2857 0.162844954921272 4090 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.983389238373391 0.154638257481563 no 2858 0.162707952383707 4096 165521 SGTC_350 k064-0020 19.8 µM -0.984235668627236 0.154432631443243 no 2859 0.162499825939755 4101 2790705 SGTC_1841 st054148 70 µM -0.984238601806612 0.154431919190927 no 2860 0.162499105009555 4089 675442 SGTC_485 niflumic acid 177 µM -0.98434434607577 0.154406243179778 no 2861 0.162473116090992 4127 4488 A COX2 inhibitor. SGTC_1326 1431-2094 10.8 µM -0.984390769362014 0.154394971925575 no 2862 0.162461707428729 4057 616278 SGTC_2802 7925815 54.55 µM -0.984522135943083 0.154363079972042 no 2863 0.162429426521205 4046 1262923 SGTC_399 oxolinic acid 75 µM -0.990808623105729 0.152841996794924 no 2864 0.160889518927613 4045 4628 A DNA gyrase inhibitor. SGTC_2139 5578692 56.4705 µM -0.991586140335103 0.152654561195969 no 2865 0.160699726470269 4038 650991 YMR113W FOL3 SGTC_1315 1237-0019 3.69 µM -0.991702464210523 0.152626532189687 no 2866 0.160671344315746 4105 825140 SGTC_2408 sulbentine 18.36 µM -0.997966152430443 0.151122296578499 no 2867 0.159147885961378 4050 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_386 1509-0011 3.07 µM -0.998424783481278 0.151012544426846 no 2868 0.159036710415479 4084 3107280 SGTC_2221 6807166 181.081 µM -0.998572362960334 0.150977239380506 no 2869 0.159000946886227 4035 674925 SGTC_2748 diazoxide 86.69 µM -1.00076453131406 0.15045345962275 no 2870 0.158470330452397 4121 3019 A potassium channel activatior. SGTC_3121 9125696 49.47 µM -1.00104504263754 0.150386523884492 no 2871 0.158402516337096 4170 1235365 SGTC_1397 3532-0190 20.1 µM -1.00128421062741 0.150329469183867 no 2872 0.15834471208414 4034 5322280 SGTC_1604 st002052 72.4 µM -1.00515440614875 0.149408220253258 no 2873 0.157411252854298 4160 6254834 YHR062C RPP1 SGTC_611 3453-1652 23.7 µM -1.00610463955613 0.149182607201287 no 2874 0.15718261856318 4117 1560575 SGTC_1817 st052116 64.4 µM -1.0065497476182 0.149077003887463 no 2875 0.157075596892313 4118 4361398 SGTC_1143 3454-2408 5.08 µM -1.01039838799739 0.148165984339804 no 2876 0.156152229939143 4076 X1143 SGTC_103 0844-0104 51.839 µM -1.01266697421038 0.147630731344934 no 2877 0.155609628858359 4019 5375804 SGTC_1721 st082152 9.2685 µM -1.01451921541061 0.147194672872747 no 2878 0.155167532601434 4035 5296051 SGTC_2358 9037157 4 µM -1.01634954110353 0.1467646227753 no 2879 0.154731482483061 4111 2388925 SGTC_3274 9138298 49.47 µM -1.01647530619268 0.146735104214026 no 2880 0.154701550422834 4062 17015756 SGTC_1991 st073000 8.92 µM -1.01728272042121 0.146545689380131 no 2881 0.154509477168014 4177 4301969 YIL048W NEO1 SGTC_2691 st077356 60.2 µM -1.0176220168936 0.146466141330842 no 2882 0.154428810046124 4157 2839272 SGTC_2321 7390090 138.78 µM -1.01857138608039 0.146243715795142 no 2883 0.154203247210236 4157 649046 SGTC_2274 7947094 46.08 µM -1.01859868874238 0.146237322474345 no 2884 0.15419676353229 4060 2971028 SGTC_1157 4092-0394 27.6 µM -1.01884737079851 0.1461790985459 no 2885 0.154137716259385 4199 3659885 SGTC_806 3966-4455 5.86 µM -1.01941181551008 0.146047002892082 no 2886 0.154003749548887 4100 714982 SGTC_316 k060-0003 58.6 µM -1.02056448607971 0.145777495310529 no 2887 0.153730411222486 4139 6152314 SGTC_2400 5203494 178.7 µM -1.02268521479976 0.145282518455695 no 2888 0.153228352117413 4027 6777674 SGTC_733 4069-0007 56.1 µM -1.02612587942028 0.144481877290166 no 2889 0.15241612657431 4113 5717425 YNL287W SEC21 SGTC_3079 9117512 49.47 µM -1.02650912239696 0.144392881192373 no 2890 0.152325832949965 4161 7185044 SGTC_202 3594-0513 34.79 µM -1.02685778386784 0.144311947659406 no 2891 0.152243717723262 4131 708429 SGTC_2391 6285546 200 µM -1.0280904024128 0.144026069514228 no 2892 0.151953652429629 4102 846083 SGTC_2832 7992762 51.95 µM -1.02820425356501 0.143999683581097 no 2893 0.151926879001293 4065 2985177 SGTC_2174 5790901 200 µM -1.0290835127563 0.143796017907286 no 2894 0.151720216491689 4131 786020 SGTC_2433 5607874 27.82 µM -1.03066073345005 0.14343116833461 no 2895 0.151349972324029 4088 2252428 SGTC_838 0109-0203 71.4 µM -1.03152568628862 0.143231349258584 no 2896 0.151147184577467 4123 759422 SGTC_2495 cafestol 54.53 µM -1.0322029374713 0.143075023816464 no 2897 0.150988529627794 4134 16667697 An anti-infammatory. SGTC_1949 st076024 69.1 µM -1.03265638765273 0.142970421339305 no 2898 0.150882364958428 4053 2921930 SGTC_1356 1502-0781 85.8 µM -1.03346087790689 0.142784967682236 no 2899 0.150694134839449 4107 567702 SGTC_502 l-744,832 89.3 µM -1.03385223718589 0.142694809114428 no 2900 0.150602623349468 4145 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.03493712155963 0.142445082433719 no 2901 0.150349138517656 4070 4330530 SGTC_2575 plumbagin 510 nM -1.03610927404986 0.142175600165596 no 2902 0.150075583052997 4038 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1570 verbenone 133 µM -1.0383183272703 0.141668668871411 no 2903 0.149560939493403 4155 29025 A natural terpanoid with antifungal properties. SGTC_2992 9074591 71.4286 µM -1.0386550528931 0.14159150509043 no 2904 0.149482596026055 4089 17741321 SGTC_385 1494-0393 12.4 µM -1.04022901343759 0.141231195188136 no 2905 0.149116757530669 4119 3090647 SGTC_2850 9015429 58.44 µM -1.04167373187317 0.140901018885855 no 2906 0.148781485806077 4163 6457570 SGTC_907 3448-6986 75.5 µM -1.04216231977604 0.140789475471198 no 2907 0.148668214681083 4173 590582 SGTC_791 1348-1292 225 µM -1.04235622174755 0.140745224740395 no 2908 0.148623277658874 4110 5437054 SGTC_1239 0337-0584 35.4 µM -1.04261738918975 0.140685638148973 no 2909 0.148562766134048 4210 914301 YML130C ERO1 SGTC_1014 4130-3005 69.3 µM -1.04415116484793 0.14033604548045 no 2910 0.14820772848921 4145 743608 SGTC_2013 4024628 200 µM -1.04540204281274 0.140051370639418 no 2911 0.14791859648309 4184 5230760 SGTC_710 3448-4187 58 µM -1.04784650873668 0.139496192258092 no 2912 0.147354665290407 4117 3946412 SGTC_2438 5259590 200 µM -1.0486607800814 0.139311590665366 no 2913 0.147167135582357 4151 1201127 SGTC_2037 5169046 200 µM -1.04878874320303 0.139282595558662 no 2914 0.147137679754979 4212 5718022 SGTC_3119 9125183 49.47 µM -1.05028016347991 0.138944958127309 no 2915 0.146794661268306 3955 22695334 SGTC_2975 9084847 53.72 µM -1.05039277440448 0.138919487179204 no 2916 0.146768783173517 4201 27211724 SGTC_1846 st056244 14.8 µM -1.05085269024642 0.138815493934463 no 2917 0.146663125864264 4170 5393182 SGTC_969 1313-0238 134 µM -1.0510719251769 0.138765940590585 no 2918 0.146612778590215 4173 5212874 SGTC_479 n-linoleoylglycine 10 µM -1.05323205451167 0.138278333955798 no 2919 0.146117325360701 4177 6433346 An anti-infammatory. SGTC_1901 st060216 58.6 µM -1.05375974713078 0.13815939547873 no 2920 0.145996463455445 4100 688792 SGTC_258 haloperidol 50.781 µM -1.05420962294186 0.138058051502941 no 2921 0.14589347764883 4138 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_541 4513-1321 94 µM -1.05457716486969 0.137975292601872 no 2922 0.145809376001518 4121 747515 SGTC_3078 9116413 49.47 µM -1.05490733344587 0.137900977863579 no 2923 0.145733853985081 4085 17177322 SGTC_1508 1080-0625 72.9 µM -1.05498745944452 0.137882947126011 no 2924 0.145715530110326 4020 767111 SGTC_1171 0368-0077 21.4 µM -1.05613196852546 0.137625574030383 no 2925 0.145453963390967 4096 3239779 SGTC_753 1322-0200 289 µM -1.05704916102912 0.137419555891954 no 2926 0.145244575799742 4226 5403907 SGTC_3022 9087993 49.47 µM -1.0593617643279 0.136901038260515 no 2927 0.144717528007917 4210 17173644 SGTC_2406 ethylparaben 405.7 µM -1.06131466099273 0.13646421446382 no 2928 0.144273462566381 4158 8434 A possible steroid mimic. SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.06878333720522 0.134802422407046 no 2929 0.142583654650313 4172 16486 A toxic proline analog. SGTC_763 3453-1109 128 µM -1.06880558313732 0.134797493482273 no 2930 0.142578641523512 4166 1560353 SGTC_2680 butyl paraben 22.24 µM -1.06960309576195 0.134620874097927 no 2931 0.142399000566492 4239 7184 An antifungal and steroid mimetic. SGTC_2934 9036370 36.88 µM -1.07059136875554 0.134402228836918 no 2932 0.142176603049359 4161 6462800 SGTC_526 4469-0568 170 µM -1.07223552077919 0.134039017574685 no 2933 0.141807129873568 4111 2901964 SGTC_1754 st042065 16.137 µM -1.07239359709534 0.134004132349051 no 2934 0.141771641322466 3966 1126236 YIL048W NEO1 SGTC_2944 9067346 25.62 µM -1.07596871738969 0.133216819262257 no 2935 0.140970623599573 4123 6473075 SGTC_1106 tegaserod maleate 11.7 µM -1.07627114607209 0.133150364732179 no 2936 0.140903004539119 4185 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2001 4023502 57.655 µM -1.07633120904292 0.133137169438978 no 2937 0.140889577871096 4212 108941 YCR052W RSC6 SGTC_3219 9131112 49.47 µM -1.07832695888029 0.132699232901964 no 2938 0.140443935116265 4080 17612988 YMR079W SEC14 SGTC_982 1491-0518 27.5 µM -1.08044845499805 0.132234792338492 no 2939 0.139971264194127 4098 3091256 SGTC_3233 9132340 49.47 µM -1.08084044164023 0.132149100937741 no 2940 0.139884047738957 4171 17682950 SGTC_720 r052-1644 49.9 µM -1.08090417536268 0.132135171858038 no 2941 0.139869870570572 4194 1422863 YOR257W CDC31 SGTC_1941 st076221 61.8 µM -1.08253054435683 0.131780069490661 no 2942 0.13950842536307 4066 2828568 SGTC_2779 methotrexate 400 µM -1.08464274143156 0.131319874734295 no 2943 0.139039958464456 4198 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_3063 1327-0034 4 µM -1.09320111537451 0.129466584045765 no 2944 0.13715275372066 4085 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1513 0337-0559 19 µM -1.0935589827142 0.129389485647631 no 2945 0.137074223473853 4164 775073 SGTC_2416 tofa 880 nM -1.09513962905722 0.129049334229141 no 2946 0.136727734704664 4192 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2735 sertaconazole 140 nM -1.09840420685506 0.128348768757927 no 2947 0.136014013112966 4315 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2451 5856223 45.7 µM -1.10038429968189 0.127925137431152 no 2948 0.13558235811919 4158 2179896 SGTC_3062 9077494 49.47 µM -1.1033703786144 0.127288119213668 no 2949 0.134933177408329 4165 16459633 SGTC_3241 9133421 49.47 µM -1.10457709431662 0.127031318451276 no 2950 0.134671440422885 4252 17018221 SGTC_1306 1185-0270 9.02 µM -1.10780823747945 0.126345476041456 no 2951 0.133972320891498 4238 1548076 SGTC_3015 9080845 49.47 µM -1.10889476812088 0.126115429833484 no 2952 0.133737790553553 4245 5296973 SGTC_2664 lyso-paf C-16 73.48 µM -1.10895288723095 0.126103132770245 no 2953 0.133725253356803 4174 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3169 9102970 49.47 µM -1.11108122170281 0.125653387326036 no 2954 0.133266694984639 4263 17027839 SGTC_1096 rimcazole 32.2 µM -1.11434263965373 0.124966379754052 no 2955 0.132566110485034 4124 18528119 A dopamine reuptake inhibitor. SGTC_313 3474-0040 5.03 µM -1.11449068482313 0.124935256877746 no 2956 0.132534369249397 4208 1043375 YIL048W NEO1 SGTC_1488 4013-0813 75.9 µM -1.11479792866236 0.124870683655738 no 2957 0.132468512152281 4136 2910057 SGTC_2097 5376186 200 µM -1.11887845687745 0.124015292842138 no 2958 0.131595997377767 4192 742755 SGTC_2629 bisabolol 100 µM -1.12046813620361 0.123683164810216 no 2959 0.131257161809203 4251 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_3037 9091026 49.47 µM -1.12123310506487 0.123523563787453 no 2960 0.131094325811551 4140 25236398 YIL048W NEO1 SGTC_542 3381-0244 89.3 µM -1.12585181976922 0.122562992388491 no 2961 0.130114122892581 4231 1112843 SGTC_2199 6590217 200 µM -1.12688405654474 0.122349032698706 no 2962 0.129895752544445 4106 703109 SGTC_1730 st033808 45.1 µM -1.12813646977657 0.122089787511061 no 2963 0.129631144582339 4158 1045166 SGTC_3348 9149464 3.537 µM -1.12895730087718 0.121920087716069 no 2964 0.129457923310953 4171 1951442 SGTC_1102 cgs 12066b 26.1 µM -1.1293697364169 0.121834882771342 no 2965 0.129370946958655 4229 6438352 A 5-HT1B full agonist. SGTC_948 3448-0295 75.3 µM -1.13158667007203 0.121377603840693 no 2966 0.128904123420627 4200 678569 SGTC_282 k297-0036 65.7 µM -1.13249253075522 0.121191102933281 no 2967 0.12871371141581 4218 5061378 SGTC_266 formosanin C 406 nM -1.13389858765606 0.120902019734117 no 2968 0.128418544815404 4100 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_935 2996-0153 430 µM -1.13911905503431 0.119832946165713 no 2969 0.12732675041516 4231 23738523 SGTC_631 k072-0230 41.5 µM -1.14126318558024 0.119395796942208 no 2970 0.12688020860391 4241 5773147 SGTC_751 0833-0568 350 µM -1.14541615919191 0.118552284369275 no 2971 0.126018403821991 4260 6954252 SGTC_583 1488-1091 88.9 µM -1.14825548278005 0.11797801716161 no 2972 0.125431555434896 4344 4303273 SGTC_336 4111-0029 111 µM -1.15014128392197 0.117597693759807 no 2973 0.125042842517065 4248 3131175 SGTC_1897 st060201 15 µM -1.15152894114629 0.117318389555439 no 2974 0.124757347973021 4262 611878 SGTC_2714 st079313 56.9 µM -1.15587387157644 0.116446892400731 no 2975 0.123866375719854 4231 2939799 SGTC_1442 4112-3290 3 µM -1.15730529620289 0.116160788402418 no 2976 0.12357382524001 4243 704353 SGTC_850 0388-0143 75.9 µM -1.15830147753091 0.115961972684069 no 2977 0.123370514319216 4228 67273 SGTC_2808 7946468 45.46 µM -1.16288129839507 0.115051050523313 no 2978 0.122438833070067 4239 2970879 SGTC_730 1436-0052 41.2 µM -1.17194648753975 0.113263022452541 no 2979 0.12060927065676 4291 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_304 1310-0298 97 µM -1.17248896650669 0.113156655440532 no 2980 0.120500399668678 4048 1550234 SGTC_2977 9011197 71.43 µM -1.17270121371843 0.113115058297303 no 2981 0.120457822271353 4326 2704722 SGTC_2007 4011539 71.82 µM -1.17296033310901 0.113064289731459 no 2982 0.120405856545697 4202 45595301 SGTC_2029 5175081 200 µM -1.17298123837922 0.113060194527026 no 2983 0.120401664736101 4225 1380876 SGTC_1838 st055369 84.5 µM -1.1737194841573 0.112915644918547 no 2984 0.120253701662195 4254 676036 SGTC_2995 9067767 71.4286 µM -1.18036368121074 0.111620635290918 no 2985 0.118927800192981 4267 11673567 SGTC_1011 4112-3381 17.4 µM -1.18067331844502 0.111560544616581 no 2986 0.118866262437027 4333 2877139 SGTC_1461 k072-0203 53.8 µM -1.18142731454473 0.111414314932425 no 2987 0.11871650622088 4177 5418714 SGTC_325 2810-4341 181 µM -1.18616496883364 0.110498634806503 no 2988 0.11777857876575 4267 774970 SGTC_2679 rapamycin 1 nM -1.19064994177671 0.10963677506876 no 2989 0.116895518531121 4182 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_24 0417-1663 219 µM -1.19108630027485 0.109553180109154 no 2990 0.116809853716377 4305 4329390 SGTC_3007 9078383 71.4286 µM -1.19534333565177 0.108740043209562 no 2991 0.115976457430856 4258 6496995 SGTC_1379 2144-0755 36.5 µM -1.19550875902721 0.108708533505459 no 2992 0.115944158056856 4334 5392327 SGTC_563 tetrahydrosecaminediol 614 µM -1.20035546158565 0.107788250486065 no 2993 0.11500065925964 4328 334274 A psychoactive constituent of the cannabis plant. SGTC_369 0957-0393 4.5 µM -1.20047413219625 0.107765788128213 no 2994 0.114977626551431 4298 6997992 SGTC_2858 9025781 8.96 µM -1.2020345524959 0.107470740343874 no 2995 0.114675070667387 4163 4894980 YPL153C RAD53 SGTC_1437 4092-1038 11.6 µM -1.20248942095767 0.107384842485521 no 2996 0.114586981214311 4327 3977136 SGTC_1425 4048-4433 7.33 µM -1.20291385429111 0.107304736673168 no 2997 0.114504829246199 4338 23734946 SGTC_1386 3228-0095 33.8 µM -1.20417115819341 0.107067691126767 no 2998 0.114261715564107 4298 870181 SGTC_2344 7990960 76.95 µM -1.20793576553616 0.106360190556751 no 2999 0.113535985522509 4264 140813 SGTC_2334 9017922 200 µM -1.21129270554013 0.105732157756009 no 3000 0.112891621699102 4342 3163164 SGTC_1037 k284-1091 78.7 µM -1.21168244484611 0.105659417473876 no 3001 0.112816980810118 4278 3334711 SGTC_643 k048-0106 28.4 µM -1.21265960752874 0.105477200588905 no 3002 0.112629994512819 4308 6763920 SGTC_2610 ononetin 44.17 µM -1.21332190695075 0.105353827278272 no 3003 0.11250338521625 4269 259632 SGTC_2062 5245942 200 µM -1.2151389723994 0.10501588002295 no 3004 0.112156545819353 4340 1376160 SGTC_2614 arthonioic acid 13.39 µM -1.22068394119213 0.103989450307963 no 3005 0.111102855154219 4156 6710684 SGTC_834 0312-0008 75.7 µM -1.22405806844251 0.103368436403274 no 3006 0.110465161347164 4322 6385573 YIL048W NEO1 SGTC_930 2810-3379 265 µM -1.22454357866867 0.10327929944777 no 3007 0.110373618643596 4326 1015764 SGTC_211 3455-0679 143.504 µM -1.22515624800404 0.103166896456929 no 3008 0.110258177803746 4331 748649 SGTC_1649 st011737 51.3 µM -1.22527910311066 0.103144367619922 no 3009 0.110235039533742 4308 1761035 SGTC_2998 9066762 71.4286 µM -1.22851133069071 0.102552933411078 no 3010 0.109627539286682 4354 4945196 SGTC_946 3434-1334 87.4 µM -1.23336556755925 0.101669341020273 no 3011 0.108719702671129 4291 4047976 SGTC_2102 5377816 72.7585 µM -1.23340022115038 0.101663053190418 no 3012 0.108713241270273 4370 1379702 SGTC_2733 amorolfine 100 µM -1.23465779061332 0.101435061089157 no 3013 0.108478945604448 4474 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2697 mebhydrolin 72.4 µM -1.23750595326294 0.100920078473863 no 3014 0.107949652776248 4374 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_447 ml7 120 µM -1.23820645368049 0.100793712007096 no 3015 0.107819759592492 4359 4216 Selective myosin light chain kinase inhibitor. SGTC_2378 9074213 121.43 µM -1.2396362604693 0.100536140825754 no 3016 0.107554981245575 4279 657714 SGTC_50 0929-0078 56.389 µM -1.24223453998667 0.100069306029222 no 3017 0.107075019662332 4162 1377751 SGTC_1899 st063254 59.6 µM -1.24379189171779 0.0997902552242972 no 3018 0.106788082672537 4262 3093813 SGTC_124 0136-0217 7.121 µM -1.24669414017708 0.0992717394632404 no 3019 0.106254834131156 4379 3976905 SGTC_2561 acetosyringone 100 µM -1.25175316933588 0.098372607851258 no 3020 0.105329909667929 4303 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_232 clozapine 119 µM -1.25338402544901 0.0980840338898123 no 3021 0.105032991116685 4331 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3247 9135149 49.47 µM -1.25549318219442 0.0977117468101449 no 3022 0.104649890765805 4366 8934436 YOR116C RPO31 SGTC_136 0097-0015 404.482 µM -1.25556763088645 0.0976986248333856 no 3023 0.104636386665622 4328 4861337 SGTC_683 panaxydol 45 µM -1.25600106492105 0.0976222554424755 no 3024 0.104557791992715 4340 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2224 6650123 117.647 µM -1.25691771237125 0.0974608899244962 no 3025 0.104391717020251 4344 2908370 SGTC_1058 3448-5425 97.3 µM -1.25752693803388 0.0973537508470943 no 3026 0.104281445440095 4281 7279705 SGTC_2154 5570129 200 µM -1.25860210001878 0.0971648825507919 no 3027 0.104087044069831 4377 673366 SGTC_2725 haloperidol 53.21 µM -1.25925287205874 0.0970506954117183 no 3028 0.103969504894931 4280 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2440 5628896 157.78 µM -1.26132517785347 0.0966877363724222 no 3029 0.103595856761197 4310 5522048 SGTC_537 1334-0398 209 µM -1.26150235292505 0.0966567509389741 no 3030 0.103563956395534 4361 5846986 SGTC_2737 bleomycin 30.5 nM -1.26219073506602 0.0965364317832549 no 3031 0.103440080868229 4444 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.26256667428252 0.0964707695651697 no 3032 0.103372475394957 4338 521171 SGTC_260 nsc-65238 3.989 µM -1.26891074602733 0.0953676475072219 no 3033 0.102236449597986 4339 3246252 SGTC_2623 humulene 100 µM -1.26897739115257 0.0953561085907884 no 3034 0.102224563923542 4339 6187145 An anti-inflammatory. SGTC_546 peri-Naphthalide 147 µM -1.26910668628196 0.0953337254032569 no 3035 0.102201507942082 4274 223824 A penicillin ester. SGTC_2326 6164455 177.58 µM -1.26922399725845 0.0953134202236851 no 3036 0.102180592254857 4293 2888790 SGTC_593 1203-0218 61.7 µM -1.27053890138556 0.0950860432801008 no 3037 0.101946367511043 4372 3666956 SGTC_1352 1496-0991 99 µM -1.27118780600703 0.0949739801943591 no 3038 0.101830921799527 4340 3000039 SGTC_504 lovastatin 124 µM -1.27182106362095 0.0948647131121645 no 3039 0.101718351599689 4365 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_481 bay k-8644 50 µM -1.27314478601325 0.0946366072132019 no 3040 0.101483334528221 4306 2303 A calcium channel antagonist. SGTC_142 0335-0849 62.6745 µM -1.27332898714976 0.0946048974581237 no 3041 0.101450662357189 4320 3889043 YPR107C YTH1 SGTC_1703 st026983 48.3 µM -1.2787131582651 0.0936814833476121 no 3042 0.100499042172384 4374 1104023 SGTC_975 1335-0046 28.5 µM -1.2847953126598 0.0926463854894689 no 3043 0.0994319103899747 4360 16486740 SGTC_2300 7976697 71.57 µM -1.28660023424358 0.0923408467502733 no 3044 0.0991168310125073 4247 2236109 SGTC_831 k061-1017 217 µM -1.29092526679146 0.091611736843507 no 3045 0.0983647965029885 4384 1240153 SGTC_2982 9019404 25.97 µM -1.29159002981619 0.091500050991625 no 3046 0.0982495793142082 4294 22333232 SGTC_1332 1480-0653 17.5 µM -1.2920853050639 0.0914169061524515 no 3047 0.0981638021467001 4356 5749438 SGTC_1069 diphenylcyclopropenone 8.49 µM -1.29549163314588 0.0908465819285483 no 3048 0.0975753429013873 4399 65057 A dermal irritant. YDR527W RBA50 SGTC_2937 9044753 11.33 µM -1.29837114358171 0.0903665258917394 no 3049 0.0970799150376074 4289 6465530 YGL099W LSG1 SGTC_1694 st024011 44.9 µM -1.29953894087015 0.0901723750138159 no 3050 0.0968795193201731 4394 2787533 SGTC_421 streptovitacin 30 mM -1.29995112410231 0.0901039219735107 no 3051 0.0968088606454779 4384 91467 include heat shock SGTC_158 k038-0087 26.446 µM -1.3010917601616 0.0899146928955395 no 3052 0.0966135239279294 4268 X158 SGTC_2288 7946289 167.31 µM -1.30223241102339 0.0897257568705402 no 3053 0.0964184743598072 4398 1246052 SGTC_405 ebelactone b 50 µM -1.30312198688718 0.0895786135713109 no 3054 0.0962665591797678 4297 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.30312400293228 0.0895782803044763 no 3055 0.0962662150944307 4407 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_11 0438-0307 1.3 µM -1.30478031532475 0.0893047913220918 no 3056 0.0959838319293397 4352 4011476 SGTC_2111 5486399 200 µM -1.309744495244 0.0884888312401694 no 3057 0.0951411428301901 4315 689674 SGTC_613 3914-0030 117 µM -1.3103384972254 0.0883915686769903 no 3058 0.0950406747796943 4087 1145395 SGTC_2459 5811157 9.22 µM -1.31103975777234 0.0882768460368587 no 3059 0.0949221658890892 4322 2870684 YBR192W RIM2 SGTC_1411 3909-8223 150 µM -1.31185169574976 0.0881441558049359 no 3060 0.0947850892067698 4378 X1411 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.31433801733655 0.0877387557317638 no 3061 0.0943662394729785 4362 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_137 0438-0332 85.389 µM -1.31469422179016 0.0876807899274381 no 3062 0.0943063446525997 4329 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1521 st012942 49.4 µM -1.32376641050229 0.0862140705314061 no 3063 0.0927903174350067 4327 24207259 SGTC_645 0845-0943 5.41 µM -1.32380931702188 0.0862071776182432 no 3064 0.0927831905225941 4390 1885106 SGTC_38 0929-0051 58.268 µM -1.32381540528899 0.0862061995742534 no 3065 0.0927821792744255 4346 1379719 SGTC_1218 1348-1416 30.7 µM -1.32926337275421 0.0853343386536872 no 3066 0.0918805468665485 4355 6787668 SGTC_3179 9107801 49.47 µM -1.33109149666409 0.0850432614834687 no 3067 0.0915794532893485 4384 4818259 SGTC_245 methotrexate 289.6 µM -1.3344670155481 0.0845077618718096 no 3068 0.0910254249178681 4347 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_906 1165-0455 526 µM -1.33468337371372 0.0844735248064607 no 3069 0.0909899987340771 4379 3252859 SGTC_899 1083-0020 478 µM -1.33482338043926 0.0844513753332617 no 3070 0.0909670796795579 4445 767123 SGTC_1020 4335-0961 93.3 µM -1.33546842888676 0.0843493830653053 no 3071 0.0908615407787088 4352 669075 SGTC_2795 7780010 54.55 µM -1.3381762842234 0.0839222369942944 no 3072 0.0904194890481728 4352 953673 SGTC_1242 0402-0103 60.1 µM -1.33942762873372 0.083725395408043 no 3073 0.0902157499917933 4322 432868 SGTC_2870 9038528 12.99 µM -1.34106624397397 0.0834681592730364 no 3074 0.0899494729095707 4417 6463316 SGTC_615 k087-0205 167 µM -1.34192169726459 0.0833341031267831 no 3075 0.0898106929092908 4421 9642773 SGTC_2701 st077767 14.721 µM -1.34288824174155 0.0831828329474043 no 3076 0.0896540821850249 4376 5721188 SGTC_1849 st056239 19.2 µM -1.34341198020997 0.0831009509419907 no 3077 0.0895693048849355 4384 5393181 SGTC_1740 st038286 13.222 µM -1.34598352034214 0.0826997920198604 no 3078 0.0891539156727929 4426 716786 SGTC_2039 Aminomethylbenzodioxan 200 µM -1.34741040839273 0.0824778278201858 no 3079 0.0889240451186488 4397 15053 SGTC_3254 9136651 49.47 µM -1.34758099982214 0.0824513209613067 no 3080 0.0888965925283607 4351 16454030 SGTC_2539 epi(13)torulosol 80 µM -1.35104386866674 0.0819146386015608 no 3081 0.0883406902477202 4380 6708597 SGTC_315 k915-0449 187 µM -1.35552748446104 0.0812236750335115 no 3082 0.087624779003421 4432 20970215 YNL149C PGA2 SGTC_415 dibenzyl ketone 100 µM -1.35790717155998 0.080858735822442 no 3083 0.0872465707427397 4397 7593 SGTC_1611 st001856 99.4 µM -1.3591527127134 0.0806682188579697 no 3084 0.0870491010544682 4388 647478 SGTC_2470 5664817 21.68 µM -1.36031310420663 0.0804910315365454 no 3085 0.086865431646724 4449 2859561 SGTC_2223 6903751 107.57 µM -1.3657727265553 0.0796613122620973 no 3086 0.0860051546409518 4388 5598863 SGTC_1316 1272-0050 65.9 µM -1.36793507865683 0.0793344863141963 no 3087 0.0856661991903683 4387 7340392 SGTC_2280 7785178 200 µM -1.36909983612983 0.079158861667335 no 3088 0.0854840347737672 4405 2954328 SGTC_893 0958-0369 48.9 µM -1.36967239384107 0.0790726381764 no 3089 0.0853945949670117 4309 6819948 SGTC_3032 9089427 49.47 µM -1.37366473899583 0.0784733927571087 no 3090 0.0847728942469716 4404 17173707 SGTC_1468 k284-1086 134 µM -1.37573804000721 0.078163554510317 no 3091 0.0844513751380781 4413 15996457 SGTC_3306 9127676 59.7925 µM -1.37878040062608 0.0777105791099492 no 3092 0.0839812356916947 4390 41905287 SGTC_454 lyso-paf C-16 6.67 µM -1.38135049593639 0.0773294741319822 no 3093 0.0835856095582221 4443 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2888 9058547 12.99 µM -1.38245211635098 0.0771665563925717 no 3094 0.083416461674848 4350 16476514 SGTC_1334 1486-0610 236 µM -1.38334330158252 0.0770349506766007 no 3095 0.0832798133357527 4485 3742339 SGTC_2948 9070189 9.45 µM -1.38362776984376 0.0769929777820006 no 3096 0.0832362303410862 4359 6473636 YDL196W YDL196W SGTC_375 3970-0961 9.27 µM -1.38610715802695 0.076627883186792 no 3097 0.0828570924893089 4391 2898222 SGTC_746 1095-0025 46.6 µM -1.38996883638881 0.0760618682577681 no 3098 0.0822691703761817 4440 6749286 SGTC_1836 st055642 81 µM -1.39373242989009 0.0755132979848955 no 3099 0.0816992096677545 4429 8571 SGTC_1375 2910-0797 186 µM -1.39440316765682 0.0754158505473446 no 3100 0.0815979460471288 4415 742508 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.4030687734524 0.0741654801048383 no 3101 0.0802981658963078 4450 390807 SGTC_1826 st055655 41.6 µM -1.40439457487434 0.0739755834271245 no 3102 0.0801006927447396 4456 676168 SGTC_2812 7970281 58.44 µM -1.40501965544767 0.0738861810967331 no 3103 0.0800077167813385 4466 2233435 SGTC_174 3553-0389 74.3 µM -1.40869185030966 0.0733626308720876 no 3104 0.0794631528874555 4467 738071 SGTC_3045 9092950 49.47 µM -1.41024730726195 0.0731417245114109 no 3105 0.0792333357447654 4429 44120432 SGTC_13 0199-0087 65 µM -1.41138329172363 0.0729807135955364 no 3106 0.0790658134347536 4554 4589825 SGTC_2751 anetholtrithion 17.25 µM -1.41549850583417 0.0723997067844755 no 3107 0.0784611930927399 4408 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1529 apigenin 74 µM -1.4159373438358 0.0723379591084211 no 3108 0.0783969250065243 4441 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3087 9117406 49.47 µM -1.41715243231461 0.0721671979374169 no 3109 0.0782191828406375 4453 42546093 SGTC_2350 9023895 38.85 µM -1.4193646404398 0.0718571011609432 no 3110 0.077896367815237 4423 2997209 SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.41979967081094 0.0717962410902902 no 3111 0.077833005418513 4457 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1868 st057644 42.7 µM -1.42200915537008 0.0714877477851887 no 3112 0.0775117965685047 4469 688665 SGTC_460 trequinsin 123 µM -1.42455144832105 0.0711340467312359 no 3113 0.0771434515594371 4533 5537 A vasodilator. SGTC_342 k048-0088 23.3 µM -1.42582955780114 0.0709567358240269 no 3114 0.0769587733599153 4444 6820570 SGTC_2251 lansoprazole 556 µM -1.43153218781931 0.0701697493236599 no 3115 0.0761388743996662 4414 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1486 3970-0793 4.53 µM -1.43584358879231 0.0695792279766935 no 3116 0.075523426690254 4488 2844330 SGTC_2195 6536160 144.242 µM -1.43593429465707 0.0695668454563158 no 3117 0.0755105193655493 4450 3834386 SGTC_3296 9122258 64.045 µM -1.43657915804545 0.0694788621928861 no 3118 0.0754188046091572 4430 4730474 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.43857199792609 0.0692075065396746 no 3119 0.0751359124256076 4501 91467 include heat shock SGTC_1342 1486-1464 234 µM -1.4387168093959 0.0691878201094586 no 3120 0.0751153873919366 4468 3253938 SGTC_3231 9132313 49.47 µM -1.4414741853116 0.068813790694092 no 3121 0.0747253825955321 4414 4905967 SGTC_1314 1222-0010 41.1 µM -1.44153435093632 0.0688056468291868 no 3122 0.0747168899941326 4463 3526027 SGTC_1717 st033143 58.0435 µM -1.44266867864734 0.0686522461697647 no 3123 0.0745569132325591 4489 674616 SGTC_2712 st079126 47.7 µM -1.45035199957535 0.0676201280781552 no 3124 0.0734801926334249 4462 3152970 SGTC_343 4130-2827 29.8 µM -1.45865311570555 0.0665185373978265 no 3125 0.0723303031872419 4460 1118244 SGTC_306 1672-3436 11.6 µM -1.45965589956115 0.0663864099478081 no 3126 0.0721923339361206 4484 6797378 SGTC_2817 7995342 71.43 µM -1.46037405989703 0.0662919096236542 no 3127 0.0720936489840294 4453 18879975 SGTC_900 1112-0045 141 µM -1.46105408542138 0.0662025233891524 no 3128 0.0720002996233907 4364 56211 YIL048W NEO1 SGTC_953 1188-0045 9.7 µM -1.46278384281581 0.065975575457107 no 3129 0.0717632677727568 4459 6144426 SGTC_2142 5622915 118.518 µM -1.46457097202378 0.0657417338576275 no 3130 0.0715190032716065 4479 5322196 SGTC_1202 1988-0068 29.6 µM -1.46706136377066 0.0654169441360807 no 3131 0.0711796815971293 4450 2850480 SGTC_951 1171-0579 82.7 µM -1.46871412574468 0.0652020836587352 no 3132 0.0709551722203478 4420 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_3229 9132204 49.47 µM -1.46976116731519 0.0650662509366862 no 3133 0.0708132249286853 4575 17682924 SGTC_1272 0839-0021 27 µM -1.47294925278504 0.0646540127378378 no 3134 0.0703823599646702 4512 5027250 SGTC_518 1021-0119 62.6 µM -1.47355966330764 0.064575314946736 no 3135 0.0703000942974383 4454 1097762 SGTC_2138 5575593 77.673 µM -1.48205470171012 0.0634877913911469 no 3136 0.0691628702257647 4492 762213 SGTC_1155 4088-0394 48.2 µM -1.48219827714661 0.0634695343096999 no 3137 0.0691437724363786 4480 2326248 SGTC_2322 7413319 38.22 µM -1.48257468948267 0.0634216890402676 no 3138 0.0690937229716039 4430 1840400 SGTC_3123 9126162 49.47 µM -1.48330326466492 0.0633291605835721 no 3139 0.0689969276841084 4489 25239884 SGTC_1994 st072947 40.9 µM -1.48416986853173 0.0632192394758038 no 3140 0.0688819306455689 4531 5286565 YDL195W SEC31 SGTC_788 1182-0090 188 µM -1.48517035806112 0.0630925209663554 no 3141 0.0687493510040457 4489 5715185 SGTC_2137 5261020 140 µM -1.48554192300232 0.06304551025562 no 3142 0.0687001632988147 4474 763655 SGTC_2370 9071495 200 µM -1.48802705815707 0.0627317899847014 no 3143 0.0683718789851524 4486 21791103 SGTC_1292 0kpi-0043 232 µM -1.4920475403678 0.0622268273229666 no 3144 0.067843341442324 4505 3333905 SGTC_2189 6047310 154.431 µM -1.49248448564144 0.0621721396294558 no 3145 0.0677860907059323 4479 711535 SGTC_1337 1486-1011 40.3 µM -1.4981618368084 0.0614649709415644 no 3146 0.0670456041281981 4493 X1337 SGTC_3212 9128307 49.47 µM -1.50330084260116 0.0608302900212401 no 3147 0.0663807414755739 4401 27243542 SGTC_2265 7929201 200 µM -1.50413195278068 0.0607281288349201 no 3148 0.0662736972177488 4464 1265108 SGTC_1828 st055811 49 µM -1.5051260234027 0.0606061126194087 no 3149 0.0661458398183896 4504 5877589 SGTC_2110 5483698 200 µM -1.5079373967942 0.0602620713906692 no 3150 0.0657852751295923 4480 2848765 YHR062C RPP1 SGTC_1786 berberine 21.6 µM -1.50818211777466 0.060232196185053 no 3151 0.0657539613557225 4404 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2269 7935389 174.42 µM -1.51100476551713 0.0598884486476888 no 3152 0.0653936183573846 4503 97605 SGTC_562 3772-2733 112 µM -1.51123962633093 0.0598599162281326 no 3153 0.0653637048724106 4491 2876874 YIL048W NEO1 SGTC_3096 9117468 49.47 µM -1.5117934576097 0.0597926753614777 no 3154 0.0652932071470926 4459 41316311 SGTC_2951 9072950 58.06 µM -1.51248552994805 0.059708733781446 no 3155 0.0652051955092901 4424 16488155 SGTC_2685 mycophenolic acid 18.85 µM -1.52028371339408 0.0587692601769597 no 3156 0.0642198427652111 4507 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1166 k206-0078 225 µM -1.52548059751997 0.0581496430500427 no 3157 0.0635696346818001 4527 5404595 SGTC_3120 9124077 49.47 µM -1.52600586671966 0.0580873026364869 no 3158 0.0635042017177212 4613 18774327 YGL155W CDC43 SGTC_1942 st076330 65.2 µM -1.52685891300319 0.0579861726380953 no 3159 0.0633980491484047 4553 24208414 SGTC_177 1327-0068 8.361 µM -1.52856883274986 0.0577838756514376 no 3160 0.0631856837205161 4503 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2287 7945887 168.79 µM -1.53317382855358 0.0572418272495629 no 3161 0.0626165154185693 4523 1245853 SGTC_2740 felodipine 17.08 µM -1.53509021893237 0.0570174338369745 no 3162 0.0623808342701917 4566 3333 L-type calcium channel blocker SGTC_1574 spiramycin 23.7 µM -1.5383076806371 0.0566422538438885 no 3163 0.0619867013315463 4485 6419898 An antibiotic and protein synthesis inhibitor. SGTC_798 1287-0182 476 µM -1.53843393450638 0.0566275714553907 no 3164 0.0619712751863126 4550 1649755 SGTC_2726 cimetidine 79.27 µM -1.5393782296862 0.0565178519918366 no 3165 0.0618559928335452 4514 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1261 0712-0010 12.7 µM -1.54290663280412 0.0561093618817819 no 3166 0.0614267156368228 4493 2840123 SGTC_766 1391-0721 126 µM -1.55121342236904 0.055156861268946 no 3167 0.0604252732888968 4535 1020919 YIL115C NUP159 SGTC_1930 st074634 34.3 µM -1.55277394825754 0.0549793565589505 no 3168 0.0602385743136883 4440 684253 YOR116C RPO31 SGTC_1044 1222-0021 1.78 µM -1.56258753553593 0.0538734168799784 no 3169 0.0590748209662638 4447 4306703 SGTC_439 amiodarone 34.4 µM -1.57087509538443 0.0529532363204518 no 3170 0.0581058322391544 4399 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2176 5809774 33.9695 µM -1.57131703753734 0.0529045190731491 no 3171 0.0580545128287297 4450 2870539 SGTC_1197 1601-0112 267 µM -1.57292962386771 0.0527270579791086 no 3172 0.0578675573833949 4506 7350313 SGTC_784 4579-0127 173 µM -1.57769617378216 0.052205271366588 no 3173 0.0573177128682136 4555 1948547 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.58231688991685 0.0517033717923341 no 3174 0.0567886234462097 4556 688788 SGTC_718 1130-0073 349 µM -1.58479984453653 0.0514352633235885 no 3175 0.0565059088734683 4553 6740020 SGTC_3328 9140624 29.0385 µM -1.5865354923768 0.0512485062273116 no 3176 0.0563089437456062 4522 4904392 SGTC_2061 5245884 80.95 µM -1.59283442081393 0.0505752643618484 no 3177 0.0555986705565687 4518 573863 SGTC_1147 3809-1045 12.3 µM -1.59665793661522 0.0501700478474196 no 3178 0.055170988370124 4559 325925 SGTC_690 glyoxal 20.3 µM -1.5996846304503 0.0498511173871143 no 3179 0.0548342815797149 4349 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_840 0245-0196 390 µM -1.60341221865732 0.049460556471259 no 3180 0.0544218375937505 4607 3827528 SGTC_3356 9151811 4.48 µM -1.60733943261726 0.0490517257546404 no 3181 0.0539899642985794 4572 1859254 YPR165W RHO1 SGTC_14 0354-0009 295 µM -1.60858065838961 0.0489230746006095 no 3182 0.0538540331481056 4649 1713507 SGTC_2734 clemastine 41.6 µM -1.61236494153209 0.0485325028160007 no 3183 0.0534412745756906 4616 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2087 5276107 200 µM -1.61582081184272 0.0481780079414342 no 3184 0.0530665302625816 4543 144405 SGTC_86 0417-1630 471.922 µM -1.62041779256683 0.0477096749038509 no 3185 0.0525712801780335 4556 3634867 SGTC_2255 7941087 197.44 µM -1.62477346292794 0.0472692967517252 no 3186 0.0521054187251798 4622 935561 SGTC_1029 k015-0030 64.7 µM -1.62521663980187 0.0472246727468037 no 3187 0.0520582030482379 4574 2208316 SGTC_1255 0566-0045 221 µM -1.62633647129826 0.0471120660331708 no 3188 0.051939048621955 4563 2788469 SGTC_1844 rapamycin 4 nM -1.63019366210886 0.0467258459564383 no 3189 0.0515302865094009 4398 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2134 5324836 1.464 µM -1.6306541512455 0.046679907451877 no 3190 0.0514816580137776 4535 699272 SGTC_2656 pseudo-anisatin 100 µM -1.64640644978403 0.0451301576645308 no 3191 0.0498400530396145 4635 6708809 A neurotoxin. SGTC_3350 9150499 3.57 µM -1.64733714140808 0.0450399050252635 no 3192 0.0497443838628648 4571 4910996 YPR165W RHO1 SGTC_2961 9083290 32.55 µM -1.64996455498648 0.0447858986356819 no 3193 0.0494750929212791 4541 17741490 SGTC_3170 9103054 49.47 µM -1.65690295354377 0.0441206678531808 no 3194 0.0487695485757145 4531 16432970 SGTC_185 k048-0037 25.491 µM -1.6583915433027 0.0439789898470009 no 3195 0.0486192311982952 4616 6827589 SGTC_367 0335-0881 7.1 µM -1.66263550215909 0.0435770800709486 no 3196 0.0481927100245071 4496 23828853 SGTC_2682 pyrogallin 40.03 µM -1.66440070005866 0.0434107882232516 no 3197 0.0480161901369566 4583 822798 An ATP competetive kinase inhibitor. SGTC_2323 6148992 148.28 µM -1.66788495039659 0.0430840554166767 no 3198 0.0476692838777301 4536 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_25 0118-0223 35.662 µM -1.66994814704039 0.0428915191190252 no 3199 0.0474648116034869 4555 5333628 SGTC_334 1502-1024 68.5 µM -1.67242663753417 0.0426611478248121 no 3200 0.0472201115332206 4586 3296216 SGTC_1048 3161-0300 24.5 µM -1.67340224932498 0.0425707412662967 no 3201 0.0471240676770198 4586 2165101 SGTC_2434 5670830 169.91 µM -1.67350253313051 0.0425614571012597 no 3202 0.0471142041458396 4583 1549830 SGTC_777 1315-0167 517 µM -1.67424390752378 0.0424928722532899 no 3203 0.0470413367363742 4600 4221767 SGTC_3353 9151644 39.2805 µM -1.67506946833104 0.0424166044963989 no 3204 0.0469603012689234 4588 4909158 SGTC_728 3030-5151 22.5 µM -1.67572259082461 0.0423563455817086 no 3205 0.0468962713620888 4637 3125388 SGTC_1803 st050068 52.4 µM -1.67861106395871 0.0420906768174295 no 3206 0.0466139344369513 4596 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2776 terbinafine 19.92 µM -1.6853747134124 0.0414738615104044 no 3207 0.0459581495638223 4592 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_445 e6 berbamine 66 µM -1.68607176640466 0.0414107118050096 no 3208 0.0458909886445287 4576 6610268 A calcium/calmodulin antagonist. SGTC_2872 9044037 25.97 µM -1.6912327368212 0.0409455730751541 no 3209 0.0453961804437805 4629 6465195 SGTC_920 mycophenolic acid 780.421 nM -1.69410516465786 0.0406885333176863 no 3210 0.0451226505526977 4570 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2407 paclitaxel 400 µM -1.69631019934276 0.040492105119702 no 3211 0.0449135749709578 4600 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1222 0366-0074 1.18 µM -1.69756403035672 0.0403807555282133 no 3212 0.0447950382542121 4597 286520 SGTC_796 1234-0020 70.7 µM -1.70467149012974 0.0397542508387542 no 3213 0.0441278549550335 4556 46495034 SGTC_1965 Pectolinarigenin 58.4 µM -1.70609561577339 0.039629673072919 no 3214 0.0439951393650047 4588 5320438 An anti-inflammatory. SGTC_7 0192-1582 4.227 µM -1.70736494717077 0.0395189039507092 no 3215 0.043877120669259 4636 252616 SGTC_1480 1070-0044 41.2 µM -1.70882774574978 0.0393915642501803 no 3216 0.0437414308163379 4638 3124987 SGTC_227 fluconazole 33.516 µM -1.71423761902688 0.0389235207917659 no 3217 0.0432425472643231 4589 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_3118 9124250 49.47 µM -1.72181217724901 0.0382758158300766 no 3218 0.0425517739847541 4572 1504786 SGTC_2879 9041815 71.43 µM -1.72393921766122 0.0380955201970719 no 3219 0.0423594082712617 4639 4942971 SGTC_1477 0139-0234 16 µM -1.7258041419172 0.0379380129676418 no 3220 0.0421913272193362 4624 620880 SGTC_2082 5219693 150 µM -1.72831601365068 0.0377267062511678 no 3221 0.0419657918045459 4562 2834649 SGTC_1917 st066507 28.5 µM -1.73263803939951 0.0373653727789133 no 3222 0.0415800118487491 4531 3156428 SGTC_199 4063-0024 41.6 µM -1.7328922851672 0.0373442054611277 no 3223 0.0415574078843469 4639 306215 SGTC_1162 k048-0130 20.1 µM -1.73531821843771 0.037142725802486 no 3224 0.0413422282839806 4600 6797406 SGTC_368 fentichlor 4.58 µM -1.74350455581065 0.0364693779062078 no 3225 0.0406227595964831 4601 7329 A pesticide. SGTC_870 0573-2213 57.6 µM -1.74869444550072 0.0360476931121991 no 3226 0.0401719253467515 4604 3916321 SGTC_2877 9040724 71.43 µM -1.7542906932189 0.0355974743432321 no 3227 0.0396903548378012 4568 6463895 SGTC_338 4055-0136 114 µM -1.75994308179704 0.0351474284451672 no 3228 0.0392087288473181 4605 2900563 SGTC_3326 9140064 16.379 µM -1.76000123671477 0.0351428224982588 no 3229 0.0392037984434182 4573 1868434 SGTC_1515 3460-0031 42.1 µM -1.76074305566775 0.035084112887245 no 3230 0.0391409509103549 4588 2876596 SGTC_1196 1588-0294 184 µM -1.7642952507713 0.0348040967115534 no 3231 0.0388411415755515 4645 6144269 SGTC_1682 st012968 530 nM -1.76523557625381 0.0347302796905638 no 3232 0.0387620908979326 4579 24207270 SGTC_1275 0867-0008 21.1 µM -1.76774331571514 0.0345340466498725 no 3233 0.0385519125272582 4598 3422836 SGTC_3286 9117135 37.221 µM -1.77121592803414 0.0342638161953683 no 3234 0.038262400775107 4550 3438150 SGTC_2132 5317594 122.667 µM -1.77536124703295 0.0339435155162488 no 3235 0.0379191292269841 4563 794577 SGTC_2266 7929956 200 µM -1.78097378029164 0.0335137744742828 no 3236 0.037458367103437 4587 2967153 SGTC_2339 9000433 200 µM -1.78142151102693 0.0334796863463139 no 3237 0.0374218083381818 4575 2988954 SGTC_550 4123-0385 25.7 µM -1.78701797747378 0.0330560008085558 no 3238 0.0369672915028974 4637 5731123 SGTC_2926 9010726 65.15 µM -1.79123486149067 0.0327396846796611 no 3239 0.0366278070422163 4612 2994293 SGTC_2728 chlorpromazine 9.18 µM -1.80164423493011 0.0319695313673969 no 3240 0.035800698472081 4708 2726 A thorazine and dopamine antagonist. SGTC_2067 5224629 34.075 µM -1.80205318797509 0.0319395824237401 no 3241 0.0357685188808798 4599 2835000 SGTC_1186 1319-0216 26 µM -1.80301422082095 0.031869294102635 no 3242 0.035692990668314 4659 4565136 SGTC_2312 7706453 155.7 µM -1.81222630154098 0.0312019988077542 no 3243 0.0349756183318616 4611 976098 SGTC_1602 st001878 87.6 µM -1.81477406516183 0.0310195002555655 no 3244 0.0347793187698148 4607 595405 YLR310C CDC25 SGTC_2488 5268135 45.7 µM -1.81518838913919 0.0309899055275212 no 3245 0.0347474817016158 4639 1270356 YLR208W SEC13 SGTC_2233 sulbentine 40.3845 µM -1.82883435856354 0.0300281696881111 no 3246 0.0337122130710572 4639 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_830 4076-0286 57.8 µM -1.83156174939387 0.0298389479551474 no 3247 0.0335083700020943 4680 6866659 SGTC_919 tnp00227 403.569 nM -1.83226344689318 0.0297904256733078 no 3248 0.0334560900992699 4589 1269246 A methoxyflavone. YNL221C POP1 SGTC_115 0527-0192 112.043 µM -1.84366888929077 0.0290108774159965 no 3249 0.0326157048114018 4599 4233931 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.84636997953348 0.0288287649711178 no 3250 0.0324192515387082 4690 688664 SGTC_3023 9089636 49.47 µM -1.86026512663255 0.0279068856933188 no 3251 0.0314240124423286 4703 17249241 SGTC_2829 7992743 58.44 µM -1.86549640206012 0.027566237804369 no 3252 0.0310559280247527 4615 16462845 SGTC_1974 st069448 26.9 µM -1.86716028753288 0.0274586189395297 no 3253 0.030939603745644 4638 6323587 YNR016C ACC1 SGTC_2842 9000675 19.48 µM -1.86754871273012 0.0274335463879546 no 3254 0.0309125004406316 4617 2989072 SGTC_849 0386-0493 241 µM -1.86834918705822 0.0273819365830755 no 3255 0.0308567073880664 4665 726119 SGTC_3085 9117376 49.47 µM -1.87180352385286 0.0271601493112516 no 3256 0.0306168952920855 4686 16480349 SGTC_814 3342-0569 96 µM -1.87282733942611 0.0270947034378096 no 3257 0.0305461156991643 4673 4346283 SGTC_377 3970-0964 33.1 µM -1.87768632857454 0.0267858915932973 no 3258 0.0302120440304859 4634 16481235 SGTC_2157 5649910 96.377 µM -1.87895037075841 0.0267060391932644 no 3259 0.0301256350448152 4637 2858091 SGTC_2707 st078556 66.6 µM -1.88480974195192 0.0263384818130507 no 3260 0.0297277646141918 4586 17250899 SGTC_795 0685-0265 78 µM -1.89275098222182 0.025847086505778 no 3261 0.0291954965021403 4658 302754 SGTC_2310 7668677 200 µM -1.90586173629407 0.0250526042695256 no 3262 0.0283340732964994 4609 2197143 SGTC_406 estrone 100 µM -1.90692592189546 0.0249890251299781 no 3263 0.0282650904434365 4641 5870 A steroid. SGTC_3316 9136639 10.545 µM -1.90923447532633 0.0248515669099962 no 3264 0.0281159253923936 4664 4903665 SGTC_794 k038-0031 316 µM -1.91260051994735 0.0246522792768015 no 3265 0.0278996065355516 4636 6624242 SGTC_1382 3002-2117 298 µM -1.91375300296853 0.0245843550704111 no 3266 0.0278258615503 4686 1497314 SGTC_1960 st011366 51.8 µM -1.92713569945599 0.0238070510356474 no 3267 0.026981360383715 4697 3972846 SGTC_1449 4112-4002 201 µM -1.92841765014568 0.0237336882856592 no 3268 0.0269015990878952 4690 2059539 SGTC_1681 tripelennamine 100 µM -1.93191753498919 0.0235343661230858 no 3269 0.0266848425593762 4599 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2841 9004761 38.96 µM -1.93235712090059 0.0235094310629424 no 3270 0.0266577213152976 4603 2991039 SGTC_1522 st012842 45.6 µM -1.94210614712546 0.0229621138601569 no 3271 0.0260621257522775 4517 3491067 YOR116C RPO31 SGTC_1608 st001473 40.5 µM -1.9545022867892 0.0222817219541358 no 3272 0.0253209223441471 4659 7292267 SGTC_2289 7946404 165.07 µM -1.96374678921674 0.0217854569992503 no 3273 0.0247797318038441 4644 1246120 YPR165W RHO1 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.97228313769986 0.0213355298757267 no 3274 0.0242886467399014 4665 229346 A bile salt which induces apoptosis. SGTC_292 k038-0015 474 µM -1.97879307983295 0.020997712356344 no 3275 0.0239196539777376 4673 46368540 SGTC_1910 st062352 60.4 µM -1.98365948371968 0.020748148635799 no 3276 0.0236469065796366 4609 2245730 SGTC_3043 9092303 49.47 µM -2.01289132784527 0.019301329939418 no 3277 0.0220630315498909 4683 25236084 SGTC_3220 9131269 49.47 µM -2.01351143474389 0.0192715910645801 no 3278 0.0220304266201762 4699 17722206 SGTC_22 0964-0034 14.468 µM -2.0182265110978 0.0190467383040231 no 3279 0.0217838381497241 4691 138402 SGTC_203 k066-0004 30.888 µM -2.02187057554785 0.018874491918196 no 3280 0.0215948621431906 4725 6795412 SGTC_668 1682-0499 62.6 µM -2.04157570952174 0.0179658649836572 no 3281 0.0205968184106135 4694 682214 SGTC_2659 sanguinarine 24.21 µM -2.04957285139388 0.0176078932808174 no 3282 0.0202030659754131 4672 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1462 k081-0014 26.5 µM -2.05084090766325 0.0175516948827596 no 3283 0.020141221172535 4143 3270634 SGTC_853 0419-0306 21 µM -2.05708809952627 0.0172770586303543 no 3284 0.0198388761119653 4737 762713 SGTC_1729 st035615 45.989 µM -2.06269806946598 0.017033572319656 no 3285 0.0195706617282414 4672 17385451 SGTC_769 0302-0231 76 µM -2.06534162071727 0.0169198563217573 no 3286 0.0194453440525673 4633 571869 YER009W NTF2 SGTC_364 0083-0097 67.7 µM -2.07251195484118 0.0166146775669105 no 3287 0.0191088612636384 4688 5207356 SGTC_3135 9127742 49.47 µM -2.08749974303471 0.0159919636285496 no 3288 0.01842149212822 4727 3643468 SGTC_3276 9139060 49.47 µM -2.11018953907415 0.015087353102121 no 3289 0.0174210166112712 4738 4870619 SGTC_871 0574-0004 149 µM -2.11481036967843 0.0149086169096935 no 3290 0.0172230563576646 4675 9551173 SGTC_932 2857-0803 154 µM -2.1151297859545 0.014896329269796 no 3291 0.017209443599419 4685 674898 SGTC_765 1319-0117 244 µM -2.12198108300645 0.0146348551249593 no 3292 0.0169196633170571 4685 3487746 YGL099W LSG1 SGTC_1510 1123-0200 71.5 µM -2.1282589489714 0.014398742314533 no 3293 0.0166578098433039 4703 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2607 solasodine 47.35 µM -2.13247413853584 0.0142420543383785 no 3294 0.0164839441498906 4652 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_496 calpeptin 138 µM -2.13376051948721 0.0141945301553391 no 3295 0.016431194610915 4696 73364 A calpain inhibitor. SGTC_655 k060-0012 42 µM -2.14777428124094 0.0136855932680567 no 3296 0.0158658455422378 4728 5994525 SGTC_800 3448-7362 155 µM -2.1581587985855 0.0133186876979213 no 3297 0.01545774376437 4760 15991913 SGTC_264 promethazine 12.5 mM -2.16097136196777 0.0132207884745193 no 3298 0.0153487758376586 4617 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_879 0831-1030 162 µM -2.16124179715567 0.0132114080600509 no 3299 0.0153383331381532 4719 1549252 SGTC_1800 st050079 29.0735 µM -2.17928917373759 0.0125982694351058 no 3300 0.0146550964866284 4577 3645560 SGTC_1226 3909-7979 35.4 µM -2.18397714481011 0.012443089523394 no 3301 0.0144819637698659 4708 6615510 SGTC_1286 0929-0070 131 µM -2.18439325666282 0.0124293958312879 no 3302 0.0144666816562585 4740 1420408 SGTC_3318 9139014 38.6185 µM -2.21562982535508 0.011438012855948 no 3303 0.0133584322457272 4716 16643984 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -2.22519402611662 0.0111485357064592 no 3304 0.0130341078597688 4727 688667 SGTC_1000 4048-0884 8.67 µM -2.22914562927055 0.0110308060692038 no 3305 0.0129021083828165 4721 13040088 SGTC_1927 st060202 13.8 µM -2.2312542820141 0.0109684268683245 no 3306 0.0128321450845337 4689 688887 SGTC_1105 epirubicin 18.1 µM -2.24455301811587 0.0105820440219991 no 3307 0.0123984208580975 4742 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_825 1988-2224 89.6 µM -2.24951930660857 0.0104408238459156 no 3308 0.0122397379490193 4725 1180859 SGTC_2651 TUB2.036 5 µM -2.25641781364297 0.0102473863632209 no 3309 0.0120222385303687 4616 15992207 YFL037W TUB2 SGTC_165 k038-0023 64.381 µM -2.25954484944774 0.0101607372050776 no 3310 0.0119247568859967 4702 46368543 SGTC_2770 toltrazuril 17.5 µM -2.27809530954075 0.0096597371782348 no 3311 0.0113604498306247 4697 68591 Kills coccidiodes. SGTC_1335 1486-0900 202 µM -2.28471797888653 0.00948617878880662 no 3312 0.0111646848610272 4731 X1335 SGTC_3115 9123671 49.47 µM -2.28831200615205 0.0093931373944942 no 3313 0.011059678913609 4780 3286988 SGTC_2864 9034755 47.6 µM -2.30324241725428 0.00901511504749871 no 3314 0.0106326037372603 4712 4930451 SGTC_422 cantharidin 155 µM -2.3116399046493 0.00880840920160548 no 3315 0.0103987678255613 4689 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2060 5238662 140 µM -2.3393139492178 0.00815632063947576 no 3316 0.00965959565001574 4727 790130 SGTC_873 0591-4978 488 µM -2.35379423683203 0.00783232824992708 no 3317 0.00929144717967125 4749 3305145 SGTC_2646 retinol 96.75 µM -2.36194417981418 0.00765500068390301 no 3318 0.00908968963674558 4765 445354 A vitamin A analog and teratogen. SGTC_2320 7373003 200 µM -2.36220177226608 0.00764945404328546 no 3319 0.00908337578569482 4712 5415828 SGTC_767 0929-0023 86 µM -2.36375235462419 0.00761614063372385 no 3320 0.00904545052196992 4759 1204563 SGTC_2314 7727897 200 µM -2.37856171030729 0.00730435112236206 no 3321 0.00869016375035846 4717 900724 SGTC_708 3448-5400 146 µM -2.40256406945784 0.00682288012710854 no 3322 0.0081402911723406 4730 3462195 SGTC_2903 5923464 63.88 µM -2.41704462491813 0.0065461646541461 no 3323 0.00782354935184736 4758 2876576 SGTC_2855 9016525 58.44 µM -2.4183554061055 0.0065216131165788 no 3324 0.00779542027805857 4714 43811474 SGTC_167 3672-0051 66.205 µM -2.4569390635097 0.00583447190936806 no 3325 0.00700632265741793 4713 3237971 SGTC_2922 7999257 32.47 µM -2.46689635258767 0.00566791243122346 no 3326 0.00681449005937782 4726 2988377 SGTC_824 1304-0008 100 µM -2.4878699783716 0.00533082366169457 no 3327 0.00642553532839956 4757 768245 SGTC_1526 st051518 75 µM -2.49236983831032 0.00526086828987849 no 3328 0.00634469153419384 4745 673993 SGTC_1709 st033179 39.1045 µM -2.49518530984389 0.00521751505807847 no 3329 0.00629456828631004 4768 573381 SGTC_1071 trifluoperazine 6.31 µM -2.56587429022972 0.00422822697422065 no 3330 0.00514580596083744 4780 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2145 5634607 200 µM -2.61546724444178 0.00363800375381783 no 3331 0.00445527337297408 4783 308662 SGTC_679 0422-0091 41.4 µM -2.64147407757678 0.00335902269994501 no 3332 0.00412730618623986 4779 627384 YHR062C RPP1 SGTC_2593 nobiletin 86.24 µM -2.70309832443121 0.00277320645804171 no 3333 0.00343482109153331 4752 72344 An anti-infammatory. SGTC_815 1582-0027 36.9 µM -2.70437836984396 0.00276208187055412 no 3334 0.00342161587151037 4779 3128206 SGTC_1500 4488-1866 171 µM -2.74247165255387 0.00244891421699017 no 3335 0.00304893564911989 4801 2900003 SGTC_2715 st079500 56.4 µM -2.74843122552828 0.00240293651551539 no 3336 0.00299405979433882 4778 28246688 SGTC_2774 tamoxifen 10.92 µM -2.75663120937181 0.00234095088973637 no 3337 0.00292000884928711 4776 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1080 nisoldipine 24.4 µM -2.77309343613282 0.00222085983195191 no 3338 0.00277630876072695 4793 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_3208 9114115 49.47 µM -2.82457674626806 0.00188045020766771 no 3339 0.00236715544046616 4748 650895 SGTC_210 3551-0445 56.827 µM -2.83721184000528 0.00180450440557624 no 3340 0.00227547030089147 4743 2865180 YOR207C RET1 SGTC_3347 9188721 44.724 µM -2.84499592170893 0.00175911631694039 no 3341 0.00222059958434185 4778 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_904 1141-0088 396 µM -2.88661622211207 0.00153358656024315 no 3342 0.0019470444846195 4782 1378119 SGTC_1472 k841-0093 193 µM -2.91637619912823 0.00138884986698272 no 3343 0.0017706161439479 4799 X1472 SGTC_2486 5283202 22.39 µM -2.95034503106959 0.00123896107815293 no 3344 0.00158709617920986 4776 1377751 SGTC_864 0469-0573 172 µM -3.00354832106935 0.00103370857377453 no 3345 0.00133425584639618 4783 689425 SGTC_993 3909-8757 62.7 µM -3.04115659490061 0.000907975858616272 yes 3346 0.0011783561322447 4778 4288324 YLR208W SEC13 SGTC_2816 7982706 58.44 µM -3.15744158668238 0.00060274568800834 yes 3347 0.000795800604741588 4772 2981853 SGTC_3154 9100113 49.47 µM -3.30117549465125 0.000356664036460234 yes 3348 0.000481403194571619 4790 25237525 SGTC_2900 5328528 85.29 µM -3.46426123374915 0.000191885350002714 yes 3349 0.000265844952700709 4782 795359 SGTC_2263 7948595 193.29 µM -3.51220181913648 0.000159125701706209 yes 3350 0.000222205191454837 4805 2971371 SGTC_178 4092-0806 87.505 µM -3.53873311711162 0.000143325431855118 yes 3351 0.000201026054870393 4768 2169044 SGTC_456 gingerol 170 µM -3.71466962237181 7.03891610898063e-05 yes 3352 0.000101734675121566 4803 442793 A herb. SGTC_366 0181-0206 4.31 µM -4.2041107991417 8.28277055070685e-06 yes 3353 1.31055263156711e-05 4803 274874 SGTC_2698 st077697 67.5 µM -4.93496230435441 2.17064478897361e-07 yes 3354 4.00831207616012e-07 4809 3154499 SGTC_44 0929-0055 61.211 µM -7.93194234853618 2.43248522648033e-16 yes 3355 1.07872296607442e-15 4764 1379590 SGTC_758 0868-0029 16 µM -12.5491309631042 5.47066839700344e-38 yes 3356 2.0094825102232e-36 4803 762687