SGTCid condition conc unit YDL186W|YDL186W.score YDL186W|YDL186W.strain.pval YDL186W|YDL186W.strain.significant YDL186W|YDL186W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_996 3970-0799 1.8 µM 9.59340153296415 1.83843665773935e-23 yes 1 4.26139397668617e-22 15 6615648 YGL040C HEM2 SGTC_1603 st002045 67.8 µM 6.85301417483285 7.18484819112336e-13 yes 2 3.61549588718271e-12 9 5887985 SGTC_2425 5628681 7.85 µM 4.69931685677443 6.02627046472683e-07 yes 3 1.30516594982403e-06 7 5714958 SGTC_1030 k029-0042 36.7 µM 4.60227567783899 9.94750684285999e-07 yes 4 2.08949777759284e-06 11 6080581 SGTC_2957 9076800 11.52 µM 4.5132578954479 1.56199127880702e-06 yes 5 3.19196578824524e-06 15 16459615 SGTC_1311 1190-0148 100 µM 4.25314147434549 5.57222727731155e-06 yes 6 1.0539615430998e-05 23 1961333 SGTC_2770 toltrazuril 17.5 µM 4.22110975756386 6.4857807826868e-06 yes 7 1.21551262345613e-05 20 68591 Kills coccidiodes. SGTC_299 1273-0059 1.44 µM 4.20109617290414 7.12731767343304e-06 yes 8 1.32812857410138e-05 23 2848077 SGTC_1217 1183-1422 255 µM 4.10575496989984 1.11077498360328e-05 yes 9 2.01498246124489e-05 9 2849664 SGTC_1225 1216-0074 20.6 µM 3.92507103476925 2.51044268524357e-05 yes 10 4.33520742385007e-05 24 4241466 SGTC_2429 5902844 64.44 µM 3.55983894908759 0.000117896959315583 yes 11 0.000185541149311712 40 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2514 salinomycin 42.74 µM 3.35463784395928 0.000264961030362136 yes 12 0.000397344744847351 84 23682228 A polyether potassium ionophore. SGTC_2537 larixol 68.93 µM 3.3432244483599 0.000276822566882126 yes 13 0.000414054455024963 49 6708759 SGTC_1089 terbinafine 2.25 µM 3.2670906836963 0.000369502195491852 yes 14 0.00054329434151536 36 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_831 k061-1017 217 µM 3.20618861804626 0.000463576857438388 yes 15 0.000672528952890754 107 1240153 SGTC_1605 st000082 49.1 µM 3.16749490831408 0.000534400967984376 yes 16 0.000768792012848634 54 1114022 SGTC_1042 0350-0096 82 µM 3.01021915581725 0.000937882436873569 yes 17 0.00130529624657295 58 3122515 SGTC_2453 5731132 22.18 µM 2.98907391974187 0.00100965726839771 no 18 0.00139912212414646 71 1362040 SGTC_929 2805-0021 398 µM 2.92827730852253 0.0012450226460096 no 19 0.00170422949032878 65 3098024 SGTC_2446 5162541 200 µM 2.92384316564856 0.00126401449242415 no 20 0.00172869447793593 40 1549321 SGTC_2340 7987427 183.45 µM 2.88850725391417 0.00142509558402993 no 21 0.00193537550447961 87 2239331 SGTC_1125 tnp00248 1.32998 µM 2.88842654917481 0.0014254840185024 no 22 0.00193587220810889 116 24207736 SGTC_1363 1636-0063 10.4 µM 2.88447593394708 0.00144461705128541 no 23 0.00196032862055435 84 6072185 SGTC_1344 1488-0097 29.1 µM 2.85949844246509 0.00157110947943253 no 24 0.00212155750932094 62 747966 SGTC_3014 9081533 49.47 µM 2.77565803776022 0.0020730342815383 no 25 0.00275450589597382 52 21367265 SGTC_1244 0416-0015 52.5 µM 2.77003864699984 0.00211138935519084 no 26 0.00280248208537775 120 96201 SGTC_2871 9038510 12.99 µM 2.75593269649581 0.00221052126140625 no 27 0.00292625190719192 75 4945164 SGTC_1316 1272-0050 65.9 µM 2.71080821498648 0.0025566177233111 no 28 0.00335597179373943 56 7340392 SGTC_3346 9158254 43.5805 µM 2.71021810605522 0.00256145145943778 no 29 0.00336194884837833 96 17639500 SGTC_2014 4013930 200 µM 2.7072703782716 0.00258572097123497 no 30 0.00339194910651438 122 64556 SGTC_1333 1482-0047 286 µM 2.63349296773488 0.00326495267704802 no 31 0.00422557928921108 100 3811116 SGTC_2303 7774051 200 µM 2.5997690465498 0.0036258142382383 no 32 0.00466432599934926 93 2953184 SGTC_2978 9011784 42.97 µM 2.5764649682292 0.00389568538134821 no 33 0.00499081597353798 151 2994934 SGTC_352 k048-0007 5.11 µM 2.56044911875256 0.00409145072182707 no 34 0.00522684849437334 176 6811911 SGTC_2270 7924575 90.91 µM 2.56038848973151 0.0040922082371601 no 35 0.00522776056569785 102 1262135 SGTC_1924 st058459 75.1 µM 2.53080928837542 0.00447709678272389 no 36 0.00568998525434668 75 688683 SGTC_1439 4092-1168 46 µM 2.51957665307186 0.00463152470546831 no 37 0.00587480271689252 86 2886240 SGTC_1235 benzylparaben 21.5 µM 2.51790794118489 0.00465486748012614 no 38 0.00590270861281208 86 7180 SGTC_1973 st070275 50.2 µM 2.50887349262033 0.0047830777495569 no 39 0.00605584259972447 84 17118334 SGTC_1477 0139-0234 16 µM 2.50807756219256 0.00479452254274456 no 40 0.00606950091686529 90 620880 SGTC_1257 0669-0121 16 µM 2.49056174377177 0.00505264345083608 no 41 0.00637706665044488 130 4307855 SGTC_2736 butenafine 14.65 µM 2.48662487684691 0.00511233477853874 no 42 0.00644806502460263 138 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3298 9116858 71.43 µM 2.45879032272098 0.00555257690763399 no 43 0.00697030050467774 100 2506942 SGTC_696 1560-0013 611 µM 2.45210546915723 0.00566319706787661 no 44 0.00710115136846093 138 1650269 SGTC_6 0844-0013 19.835 µM 2.43638999170447 0.00593099620473121 no 45 0.00741734048412198 317 1584900 SGTC_553 k007-0256 45.7 µM 2.42804959157557 0.00607763315329316 no 46 0.00759013370565288 132 6287000 SGTC_2624 nerol 100 µM 2.4254140788159 0.00612463286275879 no 47 0.00764546741081791 97 637566 A natural product oil. SGTC_43 0570-0105 72.5 µM 2.41897700917351 0.0062407829394351 no 48 0.00778211194789053 285 1114046 YDL195W SEC31 SGTC_453 enantio-paf c16 10 µM 2.3979301769755 0.00663428113573185 no 49 0.00824400392697774 368 13871343 A lipid and platelet activating factor SGTC_2438 5259590 200 µM 2.39024382249977 0.00678336410571037 no 50 0.00841859538569399 110 1201127 SGTC_3267 9137951 49.47 µM 2.38734197670022 0.00684041273359544 no 51 0.00848534841342988 66 16643986 SGTC_2521 angolensin 13.4 µM 2.3816620992404 0.00695330361009036 no 52 0.00861735181853448 105 821428 A flavenoid. SGTC_1808 st050063 61.5 µM 2.38112785868881 0.00696400611383353 no 53 0.008629860047039 104 4011993 SGTC_397 arbidol 50 µM 2.37999582181999 0.00698673240981902 no 54 0.00865641717557005 132 131410 A RNA synthesis inhibitor. SGTC_2116 5511452 16.8835 µM 2.37865092608653 0.00701381704127592 no 55 0.00868806102271222 123 870744 SGTC_1741 st038134 10.228 µM 2.3680470513479 0.00723063241653048 no 56 0.00894113079111411 170 1272587 SGTC_3312 9133330 71.43 µM 2.35694312431627 0.00746398662810246 no 57 0.00921303439178896 101 17617324 SGTC_603 3794-0023 45.9 µM 2.3555552983523 0.00749361397702785 no 58 0.00924752201134398 109 3802260 SGTC_1512 0259-0544 12.2 µM 2.33561011690708 0.00793099087729593 no 59 0.0097557854153456 164 18476 SGTC_63 0099-0242 26.702 µM 2.33351092504952 0.00797830468866053 no 60 0.0098106728030926 243 3898502 YLR359W ADE13 SGTC_1212 0520-0165 585 µM 2.32949767002807 0.00806945088021473 no 61 0.00991635814596889 164 5403258 SGTC_1989 st071868 50.2 µM 2.311129600117 0.00849839320835692 no 62 0.0104128487280629 138 16414057 SGTC_3214 9129694 49.47 µM 2.29909106969774 0.00879026222634942 no 63 0.0107498842527449 162 17158655 SGTC_1692 fluoroquinolonic acid 71 µM 2.29891868781403 0.00879450458687888 no 64 0.0107547785075364 99 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1811 st050069 61.5 µM 2.29071947981863 0.00899837306767696 no 65 0.0109898216179305 78 3877702 SGTC_495 decylubiquinone 155 µM 2.28731760543517 0.00908416636547626 no 66 0.0110886458081272 167 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_783 0848-0141 92.7 µM 2.28200929686288 0.00921946980569877 no 67 0.011244395691018 141 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1046 2001-0062 216 µM 2.25423442172498 0.00995656248321109 no 68 0.0120907121942344 151 739778 SGTC_3174 9107204 49.47 µM 2.25298685341136 0.00999084508312335 no 69 0.0121299889491132 169 3938802 SGTC_2356 9061756 188.97 µM 2.25192217843745 0.0100201832999038 no 70 0.0121635951576837 105 20104043 SGTC_2419 paclitaxel 166.5 µM 2.24784427417526 0.010133250822594 no 71 0.0122930607940235 235 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_68 0986-0284 82.829 µM 2.24196927636583 0.0102981026444164 no 72 0.0124816790245013 235 423278 YIL048W NEO1 SGTC_3077 9117319 49.47 µM 2.23127328624843 0.0106042417066123 no 73 0.0128315160353024 123 17154678 SGTC_287 k060-0039 29.6 µM 2.21278862226901 0.0111520183834246 no 74 0.0134561110315314 130 5861974 SGTC_2034 5197015 53.07 µM 2.19318882101778 0.0117595565786135 no 75 0.0141468888188617 154 780676 SGTC_2468 5987765 72.9 µM 2.18760099659895 0.0119379415460066 no 76 0.014349339595411 141 26772094 SGTC_2458 5808907 16.39 µM 2.17393475869267 0.0123841405740155 no 77 0.0148550175983892 119 2731747 SGTC_2962 9082311 13.18 µM 2.16372831078171 0.0127267341128427 no 78 0.0152426034503524 170 16459453 SGTC_1486 3970-0793 4.53 µM 2.15885535994759 0.0128931734878305 no 79 0.0154306950081051 125 2844330 SGTC_3341 9147222 25.867 µM 2.13504366238396 0.0137338222889853 no 80 0.0163787218968028 166 1939759 SGTC_1145 3546-0597 10.2 µM 2.13010402247461 0.0139140141266516 no 81 0.0165815131603782 202 875334 SGTC_1688 st021091 57.6 µM 2.12814965003099 0.0139858679442988 no 82 0.0166623389349473 135 3656366 SGTC_1971 st069429 63.5 µM 2.12218631758978 0.0142070942657146 no 83 0.0169110475363194 145 1246522 YGL099W LSG1 SGTC_1623 st003709 20.3 µM 2.11411020387519 0.0145115015382963 no 84 0.0172529279384884 290 16192618 SGTC_335 4077-0256 27.6 µM 2.10803622407788 0.0147441272937976 no 85 0.0175139281042681 192 3121989 SGTC_1810 st050138 53 µM 2.08360510270805 0.0157124877964468 no 86 0.0185980512417541 153 3444541 SGTC_401 neomycin 50 µM 2.08036029211772 0.0158451167226363 no 87 0.0187462492408328 160 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_392 N-ethylmaleimide 8.33 µM 2.07509816356703 0.0160622426201603 no 88 0.0189887189550907 180 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2367 9070478 135.38 µM 2.04278537612485 0.0174522056544035 no 89 0.0205368444162276 227 572802 SGTC_942 3253-1115 227 µM 2.03230313379152 0.0179246290561353 no 90 0.0210614887103578 225 46497897 SGTC_2622 2-methoxyxanthone 59.94 µM 2.0269885906406 0.0181682876921931 no 91 0.0213317897521078 192 71034 A hepatoprotective. SGTC_2457 5731572 11.68 µM 2.02608330902204 0.0182100727368851 no 92 0.0213781241060123 153 2865357 SGTC_2616 abietic acid 100 µM 2.019554177512 0.0185138696286349 no 93 0.0217148261301671 236 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2132 5317594 122.667 µM 2.01837444380004 0.0185692198345093 no 94 0.0217761394571665 172 794577 SGTC_2768 sulfasalazine 50.2 µM 2.01345395754204 0.0188015986646326 no 95 0.0220334470331335 201 5384001 An antioxidant and salicylic acid derivative. SGTC_2386 9075165 157.42 µM 2.01345274134043 0.0188016564064268 no 96 0.0220335109480083 162 16452277 SGTC_2603 homopterocarpin 100 µM 2.01240604291518 0.0188514066490695 no 97 0.0220885760065989 261 101795 A weak amylase inhibitor. SGTC_1277 0873-0036 22 µM 2.00909535311141 0.019009503838959 no 98 0.0222635111888852 257 5965735 SGTC_2247 cerulenin 830 nM 2.00873865200647 0.0190266046786756 no 99 0.0222824286603526 211 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_37 0566-0070 1.56 µM 2.00080193420664 0.0194105016263506 no 100 0.0227068694528702 239 1626686 SGTC_1287 0971-0001 34.6 µM 1.99868827596808 0.0195138414885297 no 101 0.0228210461553362 263 4665869 SGTC_2118 5526350 200 µM 1.99293899184832 0.0197972994806401 no 102 0.0231340639904185 225 743594 SGTC_1978 st071761 42 µM 1.98820029460794 0.0200335524730633 no 103 0.0233947712114881 192 5147680 SGTC_294 k038-0071 157 µM 1.98131234728869 0.0203812205474732 no 104 0.0237781282798684 269 24152826 SGTC_2182 6325192 200 µM 1.97252152081522 0.0208323520437327 no 105 0.0242750510189508 188 736248 SGTC_737 1950-0117 57.9 µM 1.94325392397786 0.022395706130622 no 106 0.0259927428177326 230 5393513 SGTC_2838 9002687 71.43 µM 1.94147471371066 0.0224938529440233 no 107 0.026100361809298 229 6457060 SGTC_3326 9140064 16.379 µM 1.93715198764776 0.0227338200810774 no 108 0.0263633836295944 214 1868434 SGTC_643 k048-0106 28.4 µM 1.93572419730412 0.0228135533844508 no 109 0.026450744613214 208 6763920 SGTC_2534 helenine 20.12 µM 1.93565590941254 0.0228173727399018 no 110 0.0264549289404872 184 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_3108 9121785 49.47 µM 1.93449046629996 0.0228826393140649 no 111 0.0265264265595103 226 17140271 SGTC_57 miconazole 162.5 nM 1.9315728236773 0.0230467217543477 no 112 0.0267061264196313 223 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1359 1582-0056 520 nM 1.92523898825648 0.0234063365505578 no 113 0.0270997332763542 272 3661189 SGTC_3210 9128157 49.47 µM 1.9238921393544 0.0234834120114835 no 114 0.0271840523722919 289 17590849 SGTC_1619 st003326 88.7 µM 1.91615635149508 0.023930250701395 no 115 0.0276725986630803 191 2849032 SGTC_1420 4'-methoxyflavone 42 µM 1.9085623371447 0.0243758291020519 no 116 0.0281592871937603 216 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1489 4065-0444 182 µM 1.90648107720973 0.0244991560511339 no 117 0.0282939092324677 226 2877968 SGTC_735 3076-0345 636 µM 1.90622018754445 0.0245146521801551 no 118 0.0283108220655382 298 2888990 SGTC_2627 acetyl isogambogic acid 100 µM 1.89982743887824 0.0248969420550073 no 119 0.0287278844109222 268 6857789 A caspase activator and apoptosis inducer. SGTC_953 1188-0045 9.7 µM 1.88896036153774 0.0255582682902618 no 120 0.0294485701326984 287 6144426 SGTC_432 NS 1619 61.3 µM 1.88009202179661 0.0261088015634118 no 121 0.0300477688102152 249 4552 A K+/calcium channel activator. SGTC_1563 conessine 56.1 µM 1.8730827963541 0.0265509095087678 no 122 0.0305284763007484 304 441082 An anti-amoebic, histamine inhibitor. SGTC_2299 7976368 114.88 µM 1.86539415628235 0.027043047477507 no 123 0.0310630879384249 245 2979718 SGTC_2641 levomentholum 100 µM 1.86283465855983 0.027208556610781 no 124 0.0312427660887122 171 16666 SGTC_1690 st023502 41.2 µM 1.84960730337871 0.0280774238419322 no 125 0.0321850847097237 235 24207482 SGTC_1494 4358-1428 177 µM 1.84858335334491 0.0281456369747775 no 126 0.0322589991206774 267 1564571 SGTC_1452 4194-0072 190 µM 1.84830273037412 0.0281643554837314 no 127 0.0322792804892979 283 1343545 SGTC_2702 st077768 96.8 µM 1.84686682269416 0.0282602976849495 no 128 0.0323832221075677 259 6484119 SGTC_1703 st026983 48.3 µM 1.84629622253847 0.0282984985958506 no 129 0.0324246029715485 259 1104023 SGTC_2674 ligustilide 100 µM 1.84537563015713 0.0283602216128782 no 130 0.0324914578163661 206 5319022 A signalling regulator. SGTC_848 0368-0089 85.6 µM 1.84383935081677 0.0284634740920624 no 131 0.0326032779986183 273 762535 SGTC_181 1447-1644 8.07 µM 1.83852517912971 0.0288230515387876 no 132 0.0329925275455739 277 534600 SGTC_1842 st055362 61.2 µM 1.83826454577543 0.0288407837115103 no 133 0.0330117163745436 300 676032 SGTC_736 0958-0254 92.6 µM 1.83449399284514 0.0290983292000192 no 134 0.0332903493448786 309 6812352 SGTC_1602 st001878 87.6 µM 1.8319099400865 0.029275932684668 no 135 0.0334824196890408 254 595405 YLR310C CDC25 SGTC_2152 5568786 200 µM 1.83167672784543 0.0292920056994728 no 136 0.0334997989397689 255 5399883 SGTC_1490 4089-0339 670 nM 1.82960364328095 0.0294352053022129 no 137 0.0336546142792071 185 742542 SGTC_1916 st067606 49.2 µM 1.8199324268198 0.0301109520070271 no 138 0.0343846480054427 342 19590279 SGTC_228 caffeine 993.056 µM 1.81380693610301 0.0305455678222095 no 139 0.0348537271442722 219 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_921 1561-0023 372 µM 1.80922765205606 0.030873860561495 no 140 0.0352078216880187 282 24050882 SGTC_2608 thymoquinone 42.66 µM 1.80408335379533 0.0312461373759044 no 141 0.0356091204356877 249 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.80061667596654 0.0314990980452073 no 142 0.0358816594623416 327 5024745 SGTC_1300 1094-0077 113 µM 1.79805837114356 0.0316868591194432 no 143 0.0360838791066606 250 5532636 SGTC_2316 5844804 197.44 µM 1.79278450229324 0.0320768418695729 no 144 0.0365036942482584 383 776813 SGTC_3010 9080089 71.4286 µM 1.78920975566038 0.0323434277710784 no 145 0.0367905205651528 279 17027233 SGTC_3313 9133968 57.047 µM 1.78836655697595 0.0324065748844486 no 146 0.0368584441020728 304 1494643 SGTC_1182 1222-0449 220 µM 1.78806937239407 0.0324288552548237 no 147 0.0368824081130878 259 658318 SGTC_2317 5986382 200 µM 1.78628136896659 0.0325631714379749 no 148 0.03702685598998 266 877883 SGTC_760 0568-0725 82.9 µM 1.78106139721633 0.0329579271122317 no 149 0.0374512105834664 265 3916171 SGTC_675 1309-0189 238 µM 1.77853522029582 0.0331503784332483 no 150 0.0376579963624983 275 4246530 SGTC_877 0771-0151 33.1 µM 1.77646420499593 0.0333088440079195 no 151 0.0378282183659143 304 6166523 SGTC_1091 telmisartan 47.6 µM 1.77344994721251 0.0335405968719115 no 152 0.0380770894117497 287 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1262 0737-0114 49.6 µM 1.76434580747471 0.0342486441903422 no 153 0.0388368880697025 342 765919 SGTC_3309 9129340 25.759 µM 1.76091467794983 0.0345186579026514 no 154 0.0391264226121504 296 17158987 SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.75840954523292 0.0347169025840542 no 155 0.0393389250869497 318 5282309 SGTC_131 0141-0277 33.849 µM 1.75584939892743 0.0349204658004709 no 156 0.0395570634888586 329 1547771 SGTC_3013 9080133 71.4286 µM 1.75323302322541 0.0351295111882463 no 157 0.0397810083684168 342 17050193 SGTC_2699 st077704 54.6 µM 1.74971349317516 0.0354123360823403 no 158 0.0400838821020891 318 645852 SGTC_3333 9141820 12.094 µM 1.74874381194034 0.035490585672138 no 159 0.0401676565883827 255 1939433 SGTC_1433 4060-0023 7.6 µM 1.74243346049161 0.0360032768048637 no 160 0.0407163125991431 295 3840627 SGTC_897 1000-0139 31.4 µM 1.74164101841366 0.0360680861887335 no 161 0.0407856395729946 287 6151020 SGTC_2786 7743617 45.45 µM 1.741521357511 0.0360778808791681 no 162 0.040796116452551 254 583674 SGTC_2942 9052777 62.25 µM 1.72402923437883 0.0375332821078554 no 163 0.0423512828622567 359 6469503 SGTC_3306 9127676 59.7925 µM 1.72372954008867 0.0375586293301883 no 164 0.0423783398236666 319 41905287 SGTC_2332 7982454 138.89 µM 1.72263360931793 0.037651438822319 no 165 0.0424774015838418 374 2981748 SGTC_1854 st056233 32.9 µM 1.7202637766078 0.0378527696022941 no 166 0.0426922523701856 291 5393174 SGTC_889 0919-1524 82.7 µM 1.71788186265812 0.0380560111511296 no 167 0.042909082855245 303 3905452 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.71233353039111 0.0385328865434404 no 168 0.043417610419505 589 16725076 SGTC_1431 4049-0260 9.09 µM 1.70593729182864 0.0390886702353143 no 169 0.0440098777986534 312 3854841 SGTC_521 r062-0005 13.8 µM 1.70104547430038 0.0395181209681821 no 170 0.0444672242089318 318 2832033 SGTC_940 3232-1287 54.8 µM 1.69939702616447 0.0396636991925863 no 171 0.0446222009629564 324 1585493 YIL048W NEO1 SGTC_3042 9091578 49.47 µM 1.69258183294082 0.0402701994397834 no 172 0.0452675457464097 235 25236497 SGTC_2184 6075246 200 µM 1.69140910153612 0.0403753192849215 no 173 0.0453793475937165 325 2267320 SGTC_285 1486-1325 46 µM 1.69072736120259 0.0404365306275656 no 174 0.0454444430313253 349 22310230 SGTC_1412 3909-8563 178 µM 1.68911259704293 0.0405818158978783 no 175 0.0455989271183344 353 23767530 SGTC_2880 9042983 58.44 µM 1.68464496359542 0.0409859914738595 no 176 0.0460285454050975 334 6464714 SGTC_1634 st006576 41 µM 1.68187042388553 0.0412386363278831 no 177 0.0462969844762707 323 3915356 SGTC_1111 tnp00062 510.699 nM 1.67585398177297 0.0417908209761299 no 178 0.0468833987044967 305 676306 SGTC_2990 9074105 71.4286 µM 1.67269810048844 0.0420828507764638 no 179 0.0471933716898306 292 6502001 SGTC_758 0868-0029 16 µM 1.67180578584301 0.042165720059798 no 180 0.0472813127709559 340 762687 SGTC_825 1988-2224 89.6 µM 1.67102458746774 0.0422383783404771 no 181 0.0473584106883553 365 1180859 SGTC_1813 st051246 8.6015 µM 1.66628810483758 0.0426810844574399 no 182 0.047828022402007 269 5291959 SGTC_2471 5466956 24.79 µM 1.66476180612059 0.0428245399994345 no 183 0.0479801433469158 286 724419 SGTC_3227 9130768 49.47 µM 1.66347117857597 0.0429461488667382 no 184 0.0481090777262119 285 17720899 SGTC_2281 7943571 200 µM 1.65915814080599 0.0433545687962647 no 185 0.0485419650125951 339 1244024 SGTC_2359 9039622 200 µM 1.65779040283589 0.0434847387182632 no 186 0.0486798895472997 344 6463596 SGTC_1008 4106-0037 6 µM 1.64426874059812 0.0447886645089063 no 187 0.0500603516512313 309 2905394 SGTC_2949 9072542 2.23 µM 1.6434039169047 0.0448731213481958 no 188 0.0501496951292674 406 16457352 SGTC_46 0329-0187a 2.197 µM 1.64231711882042 0.0449794374852235 no 189 0.0502621505996733 470 46494817 SGTC_2333 9017922 200 µM 1.64152197077564 0.0450573512905956 no 190 0.0503445550902596 343 3163164 SGTC_2709 st078560 56 µM 1.63688928352495 0.0455134546267124 no 191 0.0508268027552005 323 17250903 SGTC_3274 9138298 49.47 µM 1.63587341905484 0.0456139644855389 no 192 0.0509330410674279 375 17015756 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.63355658916239 0.0458438597688622 no 193 0.0511759946417855 448 551469 SGTC_2103 5378138 10 µM 1.63279648810026 0.0459194859006895 no 194 0.0512559029719479 373 244142 SGTC_1345 1488-0192 31.4 µM 1.63034734908079 0.0461638446543935 no 195 0.0515140528246074 359 658348 SGTC_659 k018-0002 107 µM 1.62524222407365 0.0466765570688923 no 196 0.0520554783603289 365 6797879 YHR007C ERG11 SGTC_640 3381-0960 37.1 µM 1.62509961207331 0.0466909450583887 no 197 0.0520706677763358 354 1745025 SGTC_3018 9082602 49.47 µM 1.61688662410793 0.0475255666726002 no 198 0.0529513781065128 379 17332089 SGTC_2190 6049624 200 µM 1.60962818417427 0.0482730951060328 no 199 0.0537395257667305 285 2265554 SGTC_2480 5767542 37.17 µM 1.60740788660975 0.0485036272918503 no 200 0.0539824605830372 345 2867358 SGTC_3328 9140624 29.0385 µM 1.60633065901924 0.0486157919313635 no 201 0.0541006387159496 370 4904392 SGTC_156 3474-0145 5.642 µM 1.60243097777829 0.0490235752501093 no 202 0.0545301696037866 381 2265471 SGTC_2055 5235184 200 µM 1.60217141082933 0.0490508144432061 no 203 0.0545588550982057 383 2836034 SGTC_1798 st045719 60.953 µM 1.6021321628934 0.0490549342095689 no 204 0.0545631935395561 311 3980186 SGTC_2349 9023730 187.07 µM 1.60126700784313 0.0491458177828307 no 205 0.0546588965231465 387 4126287 SGTC_1641 st009299 47.1 µM 1.60126615111847 0.0491459078474064 no 206 0.0546589913593015 287 4046054 SGTC_2261 9010538 184.68 µM 1.59999536404049 0.0492796465938786 no 207 0.0547998059259639 302 6457250 SGTC_2944 9067346 25.62 µM 1.59911442044963 0.0493725283032196 no 208 0.0548975905343209 406 6473075 SGTC_1120 ficusin 1.78878 µM 1.59787293292668 0.0495036609312582 no 209 0.0550356295136776 353 6199 A DNA cross-linker. SGTC_301 4119-0100 24.5 µM 1.59470136408971 0.0498399215673737 no 210 0.0553895164351015 433 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_3107 9121808 49.47 µM 1.59010866810694 0.0503300815964413 no 211 0.0559051562247231 271 662681 SGTC_1241 0364-0022 50.8 µM 1.58374387634672 0.0510157128044844 no 212 0.0566260078507605 403 4563895 SGTC_844 0330-0132 15.3 µM 1.5812531600608 0.0512860344132878 no 213 0.0569100823964943 368 2828079 SGTC_1822 st052468 42 µM 1.58051600701838 0.0513662570280253 no 214 0.0569943720391093 336 2873678 SGTC_2644 guaiazulene 100 µM 1.57971282461558 0.0514537790531989 no 215 0.0570863236585726 332 3515 A coloring agent. SGTC_1342 1486-1464 234 µM 1.5786735032189 0.0515672089031837 no 216 0.0572054827240843 390 3253938 SGTC_2284 7945075 39.21 µM 1.57337415777816 0.0521486655478693 no 217 0.0578161035799734 432 1245402 SGTC_757 1066-0008 322 µM 1.57320155920681 0.0521676906781394 no 218 0.0578360772044525 407 6842497 SGTC_2586 curcumin 80 µM 1.57070628954575 0.0524433547294154 no 219 0.0581254437942788 471 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_36 0335-0881 14.2 µM 1.57040714508561 0.0524764800926883 no 220 0.0581602106277823 477 23828853 SGTC_802 4112-3352 742 µM 1.56968596829049 0.0525564069316979 no 221 0.0582440936066542 425 704594 SGTC_2606 farnesol 9.78 µM 1.56959631406681 0.0525663499108145 no 222 0.0582545282892546 390 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2846 9008642 19.48 µM 1.56952010846157 0.0525748025630746 no 223 0.0582633988676068 362 2992898 SGTC_2920 7982904 15.77 µM 1.56947911552744 0.0525793499059998 no 224 0.0582681710163057 336 6456808 SGTC_222 nsc-310342 10.666 µM 1.56081909608759 0.0535470245011772 no 225 0.0592832202348177 244 432556 SGTC_1003 4049-0218 100 µM 1.55977343364682 0.0536648158963074 no 226 0.059406715793489 425 295161 SGTC_507 nimesulide 162 µM 1.55906776998056 0.0537444231586956 no 227 0.0594901704893765 390 4495 A COX2 inhibitor. SGTC_3219 9131112 49.47 µM 1.55223947602598 0.0545195755920416 no 228 0.0603024668604128 379 17612988 YMR079W SEC14 SGTC_2731 amoxapine 43.43 µM 1.55136607246958 0.0546193595558183 no 229 0.0604069905039141 210 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2120 5538279 151.968 µM 1.5451258030478 0.0553365009627228 no 230 0.0611579183940464 385 2058197 SGTC_83 0170-0301 39.027 µM 1.54488239538491 0.0553646237077641 no 231 0.061187356215739 245 3089716 SGTC_3109 9122853 49.47 µM 1.53831111654658 0.0561281274325744 no 232 0.0619862814802874 383 1234709 SGTC_254 nsc-64875 3.808 µM 1.53259171922732 0.0567993893426149 no 233 0.0626882415375346 388 56993 SGTC_1675 st018485 24.5 µM 1.52896895564136 0.0572278384936216 no 234 0.0631360700684831 395 3323024 SGTC_1423 4048-0112 5.59 µM 1.52609602019139 0.0575694135785657 no 235 0.0634929765409024 403 X1423 SGTC_555 4296-0685 37 µM 1.52419435625157 0.0577963908047403 no 236 0.0637300837229271 415 2908540 YHR072W ERG7 SGTC_2124 5246320 200 µM 1.52418722925194 0.0577972427846769 no 237 0.063730973640013 397 579342 SGTC_1927 st060202 13.8 µM 1.52131123377904 0.0581418533891896 no 238 0.0640908762456666 388 688887 SGTC_678 1218-2179 85.9 µM 1.51713499798834 0.058645134544693 no 239 0.0646163018298241 330 6820081 YOR116C RPO31 SGTC_1090 efavirenz 20.7 µM 1.51683195314647 0.0586817873663532 no 240 0.0646545586873816 399 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_898 1000-0849 28.3 µM 1.51281668798608 0.0591691269961895 no 241 0.0651631143338436 402 6751807 SGTC_1307 1187-1599 12.2 µM 1.51280146268477 0.0591709809394907 no 242 0.0651650485930635 402 1538471 SGTC_321 4534-3890 65.3 µM 1.51073554021643 0.059422965433014 no 243 0.0654279218007696 389 699746 SGTC_1108 betulinic acid 729.144 nM 1.51028944946456 0.059477486244976 no 244 0.0654847913417405 410 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1121 fusaric acid 630.51 nM 1.49971605420548 0.0607812703806603 no 245 0.0668439850778691 435 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.4978229430617 0.0610170476451047 no 246 0.0670896291213697 460 688761 SGTC_847 0342-0274 5.54 µM 1.49000710124299 0.0619980469885818 no 247 0.0681111843823989 423 18097 SGTC_1967 st070177 51.4 µM 1.48936810160363 0.0620787916694066 no 248 0.0681952317720781 380 5729214 SGTC_2006 4011487 200 µM 1.48805467330871 0.0622450155004468 no 249 0.068368237858141 486 45595294 SGTC_2566 crystal violet carbinol 226 nM 1.48636487493079 0.0624593820758605 no 250 0.0685913176799278 393 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_155 k072-0202 43.6 µM 1.48303005522154 0.0628841233214318 no 251 0.0690332128314307 381 5857737 SGTC_1434 4073-0095 163 µM 1.47887199412355 0.0634168654243654 no 252 0.0695872648175091 443 24133745 SGTC_2822 7994718 71.43 µM 1.47874626494609 0.0634330287382038 no 253 0.0696040711114446 345 1018011 SGTC_1981 st071826 47 µM 1.47436875014565 0.0639977888419977 no 254 0.0701911667990337 385 11838600 SGTC_3262 9137218 49.47 µM 1.46715063052484 0.0649375552529375 no 255 0.0711675417816179 263 17650664 SGTC_762 1165-0429 115 µM 1.46332223272553 0.0654403244025935 no 256 0.0716896134803891 438 5967793 SGTC_1546 5-methoxyflavanone 78.7 µM 1.46102022980607 0.0657440881237394 no 257 0.0720049449029374 457 147795 SGTC_1777 st045864 34.765 µM 1.46019760694151 0.0658529030625921 no 258 0.0721178864207671 452 4691462 SGTC_1141 3253-0389 52.6 µM 1.45967072771296 0.0659226709111042 no 259 0.0721902953010608 410 5402031 SGTC_3021 9087658 49.47 µM 1.45849785715864 0.0660781847575455 no 260 0.0723516826764669 371 25237042 SGTC_2938 9059746 27.26 µM 1.4582343113035 0.0661131680388282 no 261 0.0723879846834442 412 6471769 SGTC_1922 5578187 25 µM 1.45725826331219 0.0662428543821817 no 262 0.0725225515398248 437 1350412 SGTC_3193 9111931 49.47 µM 1.4560144177942 0.0664084080873813 no 263 0.0726943169941731 446 17087244 SGTC_3195 9113082 49.47 µM 1.45521769596049 0.0665146185960203 no 264 0.0728045016937835 402 17018038 SGTC_2564 betulinic acid 100 µM 1.45475185555263 0.0665767803940362 no 265 0.072868985506786 496 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_954 1189-0853 2.85 µM 1.45342678492018 0.0667538438489702 no 266 0.0730526470669912 453 2828194 SGTC_2271 7849410 118.62 µM 1.45268773122654 0.0668527585686891 no 267 0.0731552374678959 421 972430 SGTC_545 4218-0007 221 µM 1.45208730478024 0.0669332029142489 no 268 0.0732386657093703 431 2840508 SGTC_1401 3807-4679 7.6 µM 1.45175555112197 0.0669776829382392 no 269 0.0732847935301566 402 3291456 SGTC_2415 st077333 57.7 µM 1.44372851668118 0.0680608947115505 no 270 0.074407678299151 531 2766255 SGTC_1265 0819-1001 68.8 µM 1.44058394214205 0.0684889090636629 no 271 0.07485112982425 442 3106768 SGTC_1056 3448-1962 115 µM 1.43650691411243 0.0690469292269736 no 272 0.0754290751724539 428 715507 SGTC_1379 2144-0755 36.5 µM 1.43619636799285 0.0690895766650112 no 273 0.0754732361207713 499 5392327 SGTC_180 1486-1293 102.781 µM 1.43477216509188 0.0692854231555998 no 274 0.0756760161081211 455 4140536 SGTC_3239 9133757 49.47 µM 1.43269900723048 0.0695712734514547 no 275 0.0759719366714105 412 17036923 SGTC_1308 1187-1617 41.4 µM 1.43252953399219 0.0695946807805014 no 276 0.075996166020534 501 2882570 SGTC_1888 azatryptophan 97.5 µM 1.4303966562136 0.0698897885087365 no 277 0.0763016037071214 407 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_627 1391-0720 175 µM 1.42513688252385 0.0706216526416672 no 278 0.0770588185111045 453 997839 SGTC_351 caspofungin 25 nM 1.42406446182326 0.0707715935114724 no 279 0.0772139063544688 618 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1624 st003710 6.25 µM 1.42218848851669 0.0710344713952809 no 280 0.0774857698363721 531 24207033 SGTC_3048 9093155 49.47 µM 1.4210574771945 0.0711933206166705 no 281 0.0776500253220865 390 25236002 SGTC_2107 5363541 170.161 µM 1.42094744956734 0.0712087884138867 no 282 0.0776660186072525 472 244052 SGTC_2836 9010338 19.48 µM 1.41913706220973 0.0714636651808262 no 283 0.0779295302922797 436 2994051 SGTC_1035 k081-0041 55.2 µM 1.41857201682357 0.0715433587164555 no 284 0.0780119144728847 495 731709 SGTC_698 k064-0052 127 µM 1.41715137393781 0.0717440262667746 no 285 0.0782193375260409 393 5088751 SGTC_1699 st031318 29.054 µM 1.41636416688164 0.0718554059715191 no 286 0.0783344548149441 460 5340658 SGTC_2602 kawain 100 µM 1.41397326768915 0.0721945006016482 no 287 0.0786848758054806 520 5369129 SGTC_1451 4152-0210 104 µM 1.41369127119796 0.0722345761117018 no 288 0.0787262846815346 485 659563 SGTC_82 0054-0107 293.755 µM 1.410259207018 0.0727236862033247 no 289 0.0792315795098906 431 3104697 SGTC_2136 5328288 199.296 µM 1.40937030524876 0.0728507778471803 no 290 0.0793628499219222 384 262395 SGTC_1651 st011928 86.1 µM 1.40820028401284 0.0730183219512569 no 291 0.0795358861005692 468 720198 SGTC_2216 7189485 200 µM 1.40693589295228 0.0731997109497699 no 292 0.0797231995625037 440 731273 SGTC_2219 9098279 200 µM 1.4064898702998 0.0732637793597508 no 293 0.0797893552357524 459 902349 SGTC_2078 5212016 200 µM 1.4059050638794 0.0733478481919135 no 294 0.0798761587154613 411 1899708 SGTC_1448 4255-0083 152 µM 1.40305089800821 0.0737592079478268 no 295 0.080300830888035 478 5399660 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.39890002681072 0.0743606007991787 no 296 0.0809214822765214 439 688803 SGTC_367 0335-0881 7.1 µM 1.39671768681961 0.0746782839428305 no 297 0.08124924168435 523 23828853 SGTC_966 1300-0360 30.2 µM 1.39614768390861 0.0747614295887062 no 298 0.081335013531007 483 70588 SGTC_2876 9059903 25.97 µM 1.3931236765764 0.0752037197774549 no 299 0.0817911972626056 501 6916095 SGTC_2085 5307070 144.047 µM 1.39232557117956 0.0753207824616689 no 300 0.0819119157419377 430 2840351 SGTC_34 0469-0683 81.75 µM 1.39104623085668 0.0755087203389131 no 301 0.0821057040869599 457 3690923 SGTC_2002 4023503 131 µM 1.38472741508301 0.0764422128739298 no 302 0.0830679164549222 604 4736863 YCR052W RSC6 SGTC_587 k089-0003 57 µM 1.37882482885238 0.0773221221425608 no 303 0.0839743847361602 334 9659696 SGTC_2681 menadione 3.18 µM 1.37762008662938 0.0775026569786561 no 304 0.0841603079667786 498 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1779 st039427 55 µM 1.37590934261679 0.0777595677078537 no 305 0.0844248511988511 584 1124498 SGTC_1657 st012939 43.4 µM 1.37385372605103 0.0780691240401719 no 306 0.0847435489358744 450 24207257 SGTC_549 1661-1316 519 µM 1.37281582049531 0.0782257775171255 no 307 0.0849048056156241 504 2857282 SGTC_2487 5918373 44.05 µM 1.36778703481622 0.0789881612597798 no 308 0.0856893735848396 506 2876279 SGTC_1572 epiandrosterone 68.9 µM 1.36632744300506 0.0792104915203701 no 309 0.0859181055570196 541 441302 A steroid. SGTC_873 0591-4978 488 µM 1.3642591942636 0.0795263455367825 no 310 0.0862430019067011 549 3305145 SGTC_381 3461-2219 42.7 µM 1.36259156917537 0.0797817113308963 no 311 0.0865056336856131 527 2883159 SGTC_2930 9013230 14.89 µM 1.36102868414011 0.0800216007018018 no 312 0.086752312444058 546 2995857 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.35923114388749 0.0802981814899132 no 313 0.0870366776569024 515 5377381 SGTC_2441 5730946 39.09 µM 1.35920919998227 0.0803015623741656 no 314 0.087040153409962 512 1774275 SGTC_999 SEC7.066 22.7 µM 1.35662050620295 0.0807011561882173 no 315 0.0874509113237806 541 740511 YDR170C SEC7 SGTC_2305 7443522 69.23 µM 1.35618006921685 0.0807692917771579 no 316 0.0875209409222264 524 5415886 SGTC_2157 5649910 96.377 µM 1.35223535063867 0.0813814775473491 no 317 0.0881500191648449 508 2858091 SGTC_2394 5221648 200 µM 1.35128421471126 0.0815296078489884 no 318 0.0883022033035224 576 788586 SGTC_1743 st037606 46.3785 µM 1.34883021908032 0.0819127330729119 no 319 0.0886957529686392 494 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1725 st036284 20.55 µM 1.34551597885991 0.0824323137402728 no 320 0.0892293323441971 567 707914 SGTC_1060 3448-7350 82 µM 1.34476666876237 0.0825501279030481 no 321 0.0893502986217036 558 570178 SGTC_1753 st043925 64 µM 1.34400400120975 0.0826701723750268 no 322 0.0894735465183937 532 670181 SGTC_3250 9135583 49.47 µM 1.34349613401004 0.0827501839133111 no 323 0.0895556885095194 488 7699353 SGTC_2916 7875993 68.79 µM 1.33968845952002 0.0833519181389301 no 324 0.0901733255157444 515 1299250 SGTC_1587 estradiol valerate 56.1 µM 1.33894121705569 0.0834703914415145 no 325 0.0902949051025541 532 13791 A steroid. SGTC_707 0865-0008 204 µM 1.33554887021648 0.0840098308177477 no 326 0.0908483858317051 525 723043 SGTC_2440 5628896 157.78 µM 1.33077300616752 0.0847737032238072 no 327 0.0916318562859941 503 5522048 SGTC_1793 st048256 72.231 µM 1.32807965761788 0.0852067795811288 no 328 0.0920758964532907 488 672022 SGTC_1828 st055811 49 µM 1.32518774335301 0.0856736275520894 no 329 0.0925544447700238 464 5877589 SGTC_2703 st077852 53.4 µM 1.32428614312633 0.0858195657026389 no 330 0.0927040153999306 500 6281836 SGTC_2106 5357045 167.29 µM 1.32260575419148 0.0860920594751085 no 331 0.0929832598379397 541 668842 SGTC_669 0108-0021 26.2 µM 1.32129821374884 0.0863045391180502 no 332 0.0932009746756967 644 17201 SGTC_3015 9080845 49.47 µM 1.31925282036985 0.0866377085357747 no 333 0.0935423024693282 552 5296973 SGTC_1 0258-0098 57.368 µM 1.31801761434821 0.0868393734235113 no 334 0.0937488757356008 464 6790032 YDR047W HEM12 SGTC_204 PMA1.184 62.41 µM 1.31427097012569 0.0874532114138137 no 335 0.094377516417423 596 2252213 YGL008C PMA1 SGTC_1713 st033146 12.748 µM 1.31065361540763 0.0880489342481233 no 336 0.0949874081919453 555 674619 SGTC_752 1896-0090 130 µM 1.30789612105888 0.088505079690685 no 337 0.0954542726867252 539 772567 SGTC_776 4476-4378 112 µM 1.30591223229621 0.0888343424232688 no 338 0.0957912031398362 510 2892008 SGTC_650 1328-0195 38 µM 1.30516434292948 0.0889587048232436 no 339 0.095918446494908 557 2780821 SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.29492752140504 0.0906739779650197 no 340 0.0976726167230346 546 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2287 7945887 168.79 µM 1.29348398153548 0.090917817842429 no 341 0.0979218603602048 577 1245853 SGTC_59 0330-0160 1.33 µM 1.28999581873776 0.0915090388170059 no 342 0.0985260549282261 705 4293482 SGTC_2935 9038016 29.96 µM 1.28991995099596 0.0915219294929885 no 343 0.098539226454239 575 6463195 SGTC_2605 digitonin 300 nM 1.2893529508407 0.0916183110139085 no 344 0.0986377051231515 641 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1195 1502-0147 41.1 µM 1.2868275787772 0.0920484999550052 no 345 0.0990771960442391 587 817940 SGTC_962 1254-0300 21.5 µM 1.27940052873871 0.0933223389886481 no 346 0.10037802388318 547 7340576 SGTC_1519 esterone 74 µM 1.2792765089373 0.0933437200529216 no 347 0.100399850914836 567 698 A steroid. SGTC_1686 st019653 115.5 µM 1.27078536585153 0.0948162158545904 no 348 0.101902508150287 557 97252 SGTC_2546 rhodinyl acetate 100 µM 1.26945463491772 0.0950485281741046 no 349 0.10213948032996 584 6708682 SGTC_2272 7805186 180 µM 1.26923540120132 0.0950868410853484 no 350 0.102178559181508 551 2956062 YPR165W RHO1 SGTC_1946 st076057 65.1 µM 1.26485684434028 0.0958544139807174 no 351 0.102961324928157 429 953009 SGTC_560 2332-1943 155 µM 1.26419498815973 0.0959708345651372 no 352 0.103080024638778 566 21177716 SGTC_292 k038-0015 474 µM 1.26370158706763 0.0960576915076973 no 353 0.103168577639723 532 46368540 SGTC_2857 9024691 58.44 µM 1.2611850176845 0.096501600648924 no 354 0.103621097645912 535 16478292 SGTC_2044 5102272 200 µM 1.25588981543747 0.0974405641478697 no 355 0.104577960801103 527 592666 SGTC_980 1473-0395 201 µM 1.25575675597996 0.0974642447193329 no 356 0.104602087317041 518 768876 SGTC_1237 0330-0133 46.1 µM 1.25138842123061 0.0982440223107426 no 357 0.105396399812512 529 X1237 YHR072W ERG7 SGTC_1266 0828-0227 32.9 µM 1.25009273933516 0.0984761867492027 no 358 0.1056328358939 536 3913820 SGTC_2049 5262831 67.185 µM 1.24842075974121 0.0987763707208766 no 359 0.105938505227329 592 763417 SGTC_2021 4019055 173 µM 1.24237029938362 0.099868254481411 no 360 0.107049984333137 745 44827708 YER133W GLC7 SGTC_2133 5320837 200 µM 1.24112933787003 0.100093287384532 no 361 0.10727898661497 547 2841355 SGTC_2273 7815444 169.05 µM 1.2397614634158 0.100341763062923 no 362 0.107531817906288 552 2824616 SGTC_573 3702-0553 84.7 µM 1.23955563398243 0.100379191103765 no 363 0.107569899560198 578 1222756 SGTC_382 3229-0966 23.2 µM 1.23764273776091 0.100727519714836 no 364 0.107924280095941 627 5722370 SGTC_1209 2323-2347 50.3 µM 1.23633896841866 0.100965434084246 no 365 0.108166295931715 564 5412760 SGTC_172 1112-0046 2.638 µM 1.23531846167735 0.101151943767422 no 366 0.108356002741 526 2802135 YIL048W NEO1 SGTC_2798 7813637 45.45 µM 1.23357493831351 0.101471174008094 no 367 0.108680668257431 588 956368 SGTC_1146 3579-1023 7 µM 1.22935480104995 0.102246895904299 no 368 0.109469404459949 657 X1146 SGTC_1856 st057054 55.7 µM 1.22903296887447 0.102306229819812 no 369 0.109529722599554 638 1266018 SGTC_714 4296-0578 26.1 µM 1.22767072120548 0.102557655093462 no 370 0.109785300866386 515 1589775 SGTC_288 1315-0019 35.1 µM 1.22440717154208 0.103161823480184 no 371 0.110399332640925 624 6811474 SGTC_3139 9095020 49.47 µM 1.22436483044239 0.103169678873022 no 372 0.110407315200952 461 25236292 SGTC_3104 9120930 49.47 µM 1.2200383312626 0.103974650247227 no 373 0.111225172189147 535 17014836 SGTC_502 l-744,832 89.3 µM 1.21842082142017 0.104276764433362 no 374 0.111532048340758 615 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2516 gossypol 71.55 µM 1.21710646963402 0.10452272371603 no 375 0.11178185474583 646 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_353 1988-1175 58.3 µM 1.21651922232456 0.104632753117195 no 376 0.111893596535978 564 2788357 SGTC_1745 st081495 74 µM 1.2162071334205 0.104691261682529 no 377 0.111953013505909 670 13842402 YBL026W LSM2 SGTC_2076 5212012 200 µM 1.21030382467035 0.105802445166199 no 378 0.113081165310156 504 604802 SGTC_3106 9121286 49.47 µM 1.20866383962029 0.106112648309982 no 379 0.113396009648756 553 15943471 SGTC_1697 st025554 27.742 µM 1.20813753080391 0.106212338744826 no 380 0.113497182809125 581 1269519 SGTC_1280 0880-0253 10.1 µM 1.20647478437475 0.106527731186735 no 381 0.113817237992844 634 6836607 SGTC_2865 9030313 51.95 µM 1.20528594262443 0.106753646769193 no 382 0.114046467235179 561 42562754 SGTC_616 4092-0450 108 µM 1.20407945950628 0.106983268004824 no 383 0.114279434088168 648 787165 SGTC_2656 pseudo-anisatin 100 µM 1.20373436153651 0.107049013494331 no 384 0.114346133350375 583 6708809 A neurotoxin. SGTC_554 4483-2211 187 µM 1.19911036635465 0.107932755040046 no 385 0.115242516892599 600 747107 SGTC_2551 apiole 73.87 µM 1.19789669096443 0.108165581662786 no 386 0.115478619074794 460 10659 A possible DNA adduct former. SGTC_1548 st061468 90.8 µM 1.19641896929678 0.108449549661818 no 387 0.115766551217848 636 390799 SGTC_2437 5741531 144.16 µM 1.19138902543099 0.109420153592528 no 388 0.116750449619076 661 2262990 SGTC_1292 0kpi-0043 232 µM 1.18993906034631 0.10970110135062 no 389 0.117035172348491 601 3333905 SGTC_1554 st069299 38.7 µM 1.18800873597885 0.110075927456014 no 390 0.117414983971005 630 24207999 SGTC_988 1497-1057 103 µM 1.18708894680725 0.110254852926824 no 391 0.117596268873083 644 3533044 SGTC_143 4032-1194 15.74 µM 1.18613305345202 0.110441022628919 no 392 0.117784879554377 724 1806963 SGTC_1404 3909-7820 48.3 µM 1.18548826727784 0.110566728345346 no 393 0.117912225423238 624 23741373 SGTC_3290 9121031 71.43 µM 1.18435791550493 0.110787346006052 no 394 0.118135705951585 567 17014854 SGTC_1358 1509-0022 2.48 µM 1.18180983408308 0.111285827109091 no 395 0.118640582438455 640 3258434 SGTC_645 0845-0943 5.41 µM 1.18053294483818 0.11153622795568 no 396 0.118894157705297 607 1885106 SGTC_2528 xanthyletin 44.79 µM 1.17772501851753 0.112088286085626 no 397 0.119453124764328 623 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2980 9014342 25.29 µM 1.17089951265905 0.113438366653261 no 398 0.12081958552495 613 2996599 SGTC_1393 3470-5649 58.2 µM 1.16987329371163 0.113642350756483 no 399 0.121025981331986 539 4108395 SGTC_2153 5569715 200 µM 1.1697375933271 0.113669343823668 no 400 0.121053292302716 626 2054701 SGTC_2722 naftopidil 47.16 µM 1.1685600859454 0.1139037615716 no 401 0.121290458720205 672 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2180 6301957 200 µM 1.16795248017199 0.114024858160525 no 402 0.121412966725061 646 845462 SGTC_2804 7954240 19.48 µM 1.16753134234085 0.114108845254521 no 403 0.121497929316068 683 828705 SGTC_1458 k015-0034 6.33 µM 1.16730682033861 0.114153639455734 no 404 0.121543242658303 610 3598957 SGTC_2338 7999974 200 µM 1.16658635716093 0.11429746304712 no 405 0.12168872774896 712 315925 SGTC_566 0958-0068 16.5 µM 1.16593797119733 0.114427008383702 no 406 0.121819762674806 584 6815365 SGTC_1373 2887-0003 58.5 µM 1.16525293442725 0.114563989948309 no 407 0.1219583121675 625 776948 SGTC_746 1095-0025 46.6 µM 1.16392473914632 0.114829911427903 no 408 0.122227256463937 700 6749286 SGTC_993 3909-8757 62.7 µM 1.16028225105425 0.115561436074531 no 409 0.122966954218355 591 4288324 YLR208W SEC13 SGTC_1716 st033144 30.6155 µM 1.15721696362415 0.116179601499735 no 410 0.123591864379261 677 674617 SGTC_472 calcifediol 10 µM 1.15672590947629 0.116278848289201 no 411 0.123692180300664 585 5283731 A vitamin D metabolite. SGTC_824 1304-0008 100 µM 1.15664765588945 0.116294669650957 no 412 0.123708171747025 680 768245 SGTC_2068 5226020 147 µM 1.15618684397941 0.116387867887408 no 413 0.123802369939883 686 1810509 SGTC_912 3474-0017 2.18 µM 1.15470836043854 0.116687245744235 no 414 0.124104937358319 668 3360550 SGTC_2817 7995342 71.43 µM 1.1515780035885 0.11732291201205 no 415 0.124747262283051 572 18879975 SGTC_332 4112-0506 40.9 µM 1.15086546814671 0.117467945117524 no 416 0.124893793044897 667 2790355 SGTC_2256 7954252 200 µM 1.14963561663612 0.117718573940457 no 417 0.125146991110388 557 2972920 SGTC_435 c-PAF 6.7 µM 1.14777376745352 0.11809871597556 no 418 0.12553098465257 680 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_257 daunorubicin 18.5 µM 1.1476128410845 0.118131613746219 no 419 0.125564213168868 644 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2041 5107442 45.335 µM 1.14399036098308 0.118873863661008 no 420 0.1263138172419 680 793005 SGTC_2897 9048598 12.99 µM 1.14257973074155 0.119163792465352 no 421 0.126606562559416 627 6467404 SGTC_1123 mangostin 811.285 nM 1.14173782675199 0.119337067842837 no 422 0.126781506243858 639 5281650 An antioxidant. SGTC_2934 9036370 36.88 µM 1.13932000791364 0.119835676377866 no 423 0.127284853116815 706 6462800 SGTC_798 1287-0182 476 µM 1.134682821901 0.120796074226266 no 424 0.128254118665903 747 1649755 SGTC_2455 5377712 9.75 µM 1.13458928038287 0.120815502996302 no 425 0.128273723327305 597 2243908 SGTC_3038 9091290 49.47 µM 1.13423955779532 0.120888160595355 no 426 0.128347037479635 668 25236843 SGTC_901 1112-0062 60.1 µM 1.13384940718407 0.120969253713129 no 427 0.128428861092825 661 1908457 SGTC_845 0330-0138 4.51 µM 1.12744878378579 0.122305095641312 no 428 0.129776391575247 677 9039800 SGTC_701 4424-0219 185 µM 1.12726258201969 0.122344111261796 no 429 0.129815738857206 751 2911779 SGTC_491 tetrandrine 80.3 µM 1.126336761804 0.122538231870234 no 430 0.130011501474782 638 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1109 tnp00067 928.257 nM 1.12322586225769 0.123192089924817 no 431 0.130670790671698 691 676295 SGTC_76 0433-0009 400.328 µM 1.12009798525128 0.123851977580424 no 432 0.131336004554427 607 2841569 SGTC_778 3456-2434 196 µM 1.1199332458836 0.123886801073472 no 433 0.131371104817055 782 5539063 SGTC_2465 5809242 33.21 µM 1.11771461254777 0.124356455446696 no 434 0.131844449905778 684 2731748 SGTC_539 4859-0462 2.54 µM 1.11381588171559 0.125184777090918 no 435 0.13267909110425 703 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1628 st004252 77.7 µM 1.11247090418709 0.125471421877144 no 436 0.132967866717744 712 692968 SGTC_493 zm226600 134 µM 1.11079144256507 0.125829995413806 no 437 0.133329065380621 701 5240098 A potassium channel opener. YCR052W RSC6 SGTC_3156 9099931 49.47 µM 1.11056549799828 0.125878290210653 no 438 0.133377710322062 727 18111053 SGTC_2030 5175110 200 µM 1.10932012300285 0.12614471639811 no 439 0.133646053566857 698 2831986 SGTC_1198 1612-1005 86.7 µM 1.10812140399794 0.126401532381875 no 440 0.133904694149076 723 6998509 SGTC_2793 7325131 81.82 µM 1.10418186702032 0.127248111768877 no 441 0.134757126939654 668 4176441 SGTC_3056 9094900 49.47 µM 1.1022908259461 0.127655881527148 no 442 0.135167628229232 679 25236784 SGTC_1207 2099-0101 141 µM 1.10112568438005 0.127907575613199 no 443 0.135420979972731 747 5837381 SGTC_2254 7938975 95.19 µM 1.10010873607335 0.128127538615843 no 444 0.135642373972753 790 2969277 SGTC_1878 temozolomide 1 mM 1.09812551789984 0.128557258484024 no 445 0.136074842007648 682 5394 DNA alkylating agent. SGTC_1264 0783-0040 158 µM 1.09571553283363 0.129080794298536 no 446 0.13660164151061 668 2855798 SGTC_3331 9141060 1.957 µM 1.09390815870416 0.129474390020256 no 447 0.136997630069326 673 4906567 YPR165W RHO1 SGTC_2872 9044037 25.97 µM 1.09387141233175 0.129482400971949 no 448 0.137005689182691 667 6465195 SGTC_3105 9121040 49.47 µM 1.09290090057731 0.129694103257071 no 449 0.137218656421437 466 41448907 SGTC_1127 asiatic acid 681.4 nM 1.09266870376278 0.129744788956659 no 450 0.137269642748798 687 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_496 calpeptin 138 µM 1.09016712738207 0.130291722267417 no 451 0.13781976545078 619 73364 A calpain inhibitor. SGTC_1814 st052110 31.539 µM 1.08724273466769 0.130933117906906 no 452 0.138464774559339 680 674163 SGTC_379 3970-0972 5.9 µM 1.08690382954777 0.131007589477993 no 453 0.13853965685528 711 2898042 YBL034C STU1 SGTC_106 0092-0003 11.579 µM 1.08101054867692 0.132307269164354 no 454 0.139846210666666 647 1072148 SGTC_1291 0993-0025 5.79 µM 1.07689805806293 0.133219468677653 no 455 0.140762905382708 752 4353356 SGTC_1014 4130-3005 69.3 µM 1.07413449179057 0.133834886466213 no 456 0.141381203752619 739 743608 SGTC_1889 st059080 5.18 µM 1.07158476414905 0.134404415197672 no 457 0.141953289816986 784 176925 Isolated from Daphnopsis sellowiana. SGTC_3264 9137442 49.47 µM 1.07038764111329 0.134672387975717 no 458 0.142222429964795 689 17015726 SGTC_2395 5646831 180.19 µM 1.06925890762959 0.134925387566328 no 459 0.142476510688786 745 6808628 SGTC_162 k030-0015 37.8 µM 1.06594120526711 0.135670919556088 no 460 0.143225110357901 771 1809920 YMR134W ERG29 SGTC_1066 ketoconazole 628 nM 1.06589644250933 0.135680997600708 no 461 0.143235228666259 780 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_3223 9129970 49.47 µM 1.06171094455372 0.13662560159957 no 462 0.144183464627341 773 17248386 SGTC_2694 st077685 81.9 µM 1.06059649740514 0.136877871848999 no 463 0.144436657513365 713 2838096 SGTC_1131 3454-3128 32.3 µM 1.05654287475603 0.137798148343204 no 464 0.145360131749104 795 710982 SGTC_2227 7312221 64.1025 µM 1.05569596769553 0.13799094991902 no 465 0.145553569994261 760 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1330 1469-0054 61.8 µM 1.05503687538334 0.138141122017123 no 466 0.145704230037725 785 7102664 SGTC_2150 5556613 200 µM 1.05416018993822 0.138341044661324 no 467 0.145904791489898 780 743190 SGTC_626 0214-0009 33 µM 1.05340877011887 0.13851255814956 no 468 0.146076843207195 767 3437874 SGTC_804 1595-0054 20.9 µM 1.0519682415767 0.138841767458739 no 469 0.146407060301392 700 761523 Stimulates phospholipase C. SGTC_1354 1498-1681 81 µM 1.05126708532983 0.139002197924928 no 470 0.14656796984522 805 5754243 SGTC_1057 3448-5381 134 µM 1.05100644346536 0.139061867146341 no 471 0.146627815242013 766 5497911 SGTC_1310 1188-0297 994 nM 1.05082211082428 0.13910407728131 no 472 0.146670149346565 759 1588352 SGTC_2213 7173844 200 µM 1.04960961190521 0.139381943449476 no 473 0.146948818020274 774 892728 SGTC_1714 st033236 13.627 µM 1.04857444279577 0.139619469877166 no 474 0.147187011792985 756 2916566 SGTC_3318 9139014 38.6185 µM 1.04644743194474 0.140108390058732 no 475 0.147677251671809 722 16643984 SGTC_738 1315-0003 72.4 µM 1.04387119981196 0.140702125287379 no 476 0.148272492270508 777 6251474 SGTC_2224 6650123 117.647 µM 1.04193867459157 0.141148626883779 no 477 0.148720056007876 722 2908370 SGTC_2037 5169046 200 µM 1.03951859621909 0.141709129087272 no 478 0.149281806981773 738 5718022 SGTC_1630 st005209 31.3 µM 1.03646723137472 0.142417986493288 no 479 0.14999210960687 845 3367314 SGTC_3286 9117135 37.221 µM 1.03430344688622 0.142922102697582 no 480 0.150497162986633 723 3438150 SGTC_943 3253-1379 105 µM 1.03413198392044 0.142962101458682 no 481 0.150537232894518 751 668464 SGTC_1179 1021-1431 9.29 µM 1.02885882782805 0.144195913711242 no 482 0.151773009023315 798 2840958 SGTC_215 1287-0124 461.5 µM 1.02826326870276 0.144335712373769 no 483 0.151913002135583 759 5560863 SGTC_182 3448-4371 550.524 µM 1.02474512279307 0.145163408249143 no 484 0.152741733008811 828 3491403 SGTC_1239 0337-0584 35.4 µM 1.02405243838939 0.145326748111169 no 485 0.152905253698776 842 914301 YML130C ERO1 SGTC_1529 apigenin 74 µM 1.0233667955051 0.145488549253978 no 486 0.153067226381062 777 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2134 5324836 1.464 µM 1.02317232359946 0.145534463669776 no 487 0.15311318810123 711 699272 SGTC_2907 7721985 69.9 µM 1.02166202813132 0.145891372984188 no 488 0.15347044445979 758 3267881 SGTC_3137 9097352 49.47 µM 1.01831621161398 0.146684141508705 no 489 0.15426385328153 808 44120435 SGTC_2300 7976697 71.57 µM 1.01704330660914 0.146986505366334 no 490 0.15456641412596 673 2236109 SGTC_1706 st031321 9.9705 µM 1.01429478932974 0.14764080859826 no 491 0.155221054831102 822 6103185 SGTC_1648 st011736 69.8 µM 1.0138659215359 0.147743079171105 no 492 0.15532336721107 770 2855514 SGTC_598 3937-0236 20.2 µM 1.01347944432271 0.14783528164254 no 493 0.155415604844815 849 1379313 SGTC_3337 9144342 33.5465 µM 1.01286894959413 0.14798100680146 no 494 0.155561380692109 797 17682949 SGTC_2411 st077133 39.94 µM 1.0094799193383 0.148791716661117 no 495 0.156372263636114 839 1403142 YNL221C POP1 SGTC_2769 toremifene 3.73 µM 1.00171015054644 0.150661553278012 no 496 0.158241801400117 763 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2482 5981709 142.65 µM 0.998902576998743 0.151341043198772 no 497 0.158920943877324 808 877755 SGTC_1312 1218-2183 165 µM 0.997530202694565 0.151673926175535 no 498 0.159253610572575 835 6744073 SGTC_357 1325-0123 420 µM 0.995653419703717 0.152129945709382 no 499 0.159709284855171 794 1098503 SGTC_188 3229-0966 278.469 µM 0.992804083000171 0.152824014399726 no 500 0.160402719897179 926 5722370 SGTC_893 0958-0369 48.9 µM 0.990467818210705 0.153394668515395 no 501 0.160972755729697 832 6819948 SGTC_1942 st076330 65.2 µM 0.987375985141273 0.154152044543137 no 502 0.161729176362894 792 24208414 SGTC_2383 9036125 200 µM 0.986609989784379 0.154340064583857 no 503 0.161916935507498 789 79580 SGTC_2533 agelasine 13.65 µM 0.986540448265306 0.15435714164304 no 504 0.161933988404584 845 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2371 9071574 200 µM 0.986319171686208 0.154411488043777 no 505 0.161988257395272 774 45596039 SGTC_703 3875-0075 71.8 µM 0.9852604317089 0.154671693807365 no 506 0.162248081654986 871 2850814 SGTC_3289 9119912 71.43 µM 0.984502074266488 0.154858252769552 no 507 0.162434356037075 800 17014829 SGTC_1632 st005650 90 µM 0.983368375723438 0.155137424225697 no 508 0.162713084432757 787 2759605 SGTC_775 4577-0580 57.3 µM 0.980987774025951 0.15572472433596 no 509 0.163299385322693 822 2006902 SGTC_998 3996-0085 177 µM 0.980882906234775 0.155750629141355 no 510 0.163325243963729 898 715391 SGTC_260 nsc-65238 3.989 µM 0.978990519248539 0.156218581418667 no 511 0.163792331996662 813 3246252 SGTC_2393 9031399 185.94 µM 0.978973552533231 0.156222781158563 no 512 0.163796523720453 830 1526623 YDL150W RPC53 SGTC_3266 9136860 49.47 µM 0.978376793712894 0.156370543090712 no 513 0.163944000681112 819 4871271 YPR165W RHO1 SGTC_2214 7179297 48.276 µM 0.977486210457848 0.156591229275247 no 514 0.164164250632653 832 769744 SGTC_2714 st079313 56.9 µM 0.973515411227008 0.157577685786551 no 515 0.165148602271762 817 2939799 SGTC_81 0411-0046 9.971 µM 0.972809571788168 0.157753462344685 no 516 0.1653239772889 761 12925265 SGTC_2147 5545932 89.7195 µM 0.972101474180335 0.157929930619481 no 517 0.165500034418423 810 797404 SGTC_2058 5236698 133 µM 0.969957863537747 0.158464939554904 no 518 0.166033747849713 802 766665 SGTC_543 3844-1095 191 µM 0.969839057304529 0.158494626309139 no 519 0.166063360564677 863 4230703 SGTC_1656 st012921 11 µM 0.966250183086085 0.159393116937388 no 520 0.166959503641182 777 6732821 SGTC_1139 k015-0024 46.9 µM 0.965558907572661 0.159566563127335 no 521 0.167132472942788 848 2766652 SGTC_2666 tannic acid 100 µM 0.964751252489582 0.159769366238236 no 522 0.167334708752363 871 16134267 A thiamine antagonist. SGTC_1976 st070609 63.5 µM 0.961886166198394 0.160490152233109 no 523 0.168053394161166 861 682556 SGTC_220 paclitaxel 373.376 µM 0.961553436045646 0.160573996514052 no 524 0.168136985573194 764 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3041 9091929 49.47 µM 0.960942532952713 0.160728011746653 no 525 0.168290531691104 863 25236887 SGTC_1285 0929-0069 65.5 µM 0.960808729597151 0.160761757883808 no 526 0.16832417424342 833 1206237 SGTC_1022 4477-0945 21.3 µM 0.96065764367622 0.160799868365172 no 527 0.168362167398975 824 4648966 SGTC_3257 9139206 32.98 µM 0.95757084947665 0.161579784202943 no 528 0.169139602151909 818 4910041 SGTC_2591 skatole 100 µM 0.956786097540774 0.16177845376385 no 529 0.169337615375081 826 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2830 7992007 71.43 µM 0.954535316480268 0.162349149169919 no 530 0.169906370697313 795 1952075 SGTC_909 3448-9333 149 µM 0.953485060143346 0.162615894121559 no 531 0.170172181101046 799 3344074 SGTC_159 3970-0959 50 µM 0.953414015300631 0.162633948438341 no 532 0.170190171526938 1017 6615653 SGTC_1746 st038117 42 µM 0.953167466976358 0.162696612805736 no 533 0.170252613510582 831 2898218 SGTC_1168 k815-0004 80.5 µM 0.95266710707374 0.162823835891634 no 534 0.170379382117597 853 642433 SGTC_1944 st076371 56.9 µM 0.948423233626372 0.163905497078815 no 535 0.171457018098154 816 24208455 SGTC_2048 5246248 200 µM 0.948370235119747 0.163919034534437 no 536 0.171470503355229 846 677046 SGTC_1906 st060206 94.7 µM 0.947279692251678 0.164197753921171 no 537 0.171748138070606 916 5133468 SGTC_376 3970-0862 59.1 µM 0.947062181521219 0.16425338174541 no 538 0.171803547138431 877 3135186 SGTC_1796 st049173 110.4 µM 0.947059694898881 0.164254017763487 no 539 0.171804180650996 816 94134 SGTC_2950 9072895 21.46 µM 0.946613108772901 0.164368269632159 no 540 0.171917980836646 855 17332245 SGTC_3253 9135987 49.47 µM 0.945842492099277 0.164565540626531 no 541 0.172114464444689 806 4182430 SGTC_2166 5933061 31.504 µM 0.945209232571789 0.164727764216506 no 542 0.172276033432572 843 2877375 SGTC_1240 0356-0016 42.1 µM 0.943976730885586 0.165043794016894 no 543 0.17259076961866 837 4305613 SGTC_1738 st035555 74 µM 0.942931692754504 0.165312062989022 no 544 0.172857921459677 857 5331140 SGTC_1591 genipin 88.4 µM 0.942302159211131 0.16547380498762 no 545 0.173018981508287 839 442424 A DNA cross-linking agent. SGTC_128 0906-2981 13.371 µM 0.942020472612868 0.165546210049936 no 546 0.17309107924069 802 6740226 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.940552362211098 0.16592390656098 no 547 0.173467152065887 807 77254 SGTC_2801 7907800 81.82 µM 0.939932988561926 0.166083417936281 no 548 0.173625967390183 861 6620925 SGTC_811 0416-0114 265 µM 0.939428615161699 0.166213385705307 no 549 0.173755363501256 844 6612453 SGTC_1472 k841-0093 193 µM 0.938144861380428 0.166544481802438 no 550 0.174084984958045 912 X1472 SGTC_569 4130-2812 160 µM 0.935757145759683 0.167161434886457 no 551 0.174699120236361 766 743552 SGTC_3064 1327-0027 10 µM 0.934672231730526 0.16744224805769 no 552 0.174978620778051 725 16000455 YPR107C YTH1 SGTC_3209 9113616 49.47 µM 0.933467171035015 0.167754515422974 no 553 0.175289406466488 916 16649353 SGTC_1432 4049-0298 68.4 µM 0.932486224768431 0.168008984702695 no 554 0.175542651209832 888 741646 SGTC_3080 9117754 49.47 µM 0.931948470002165 0.168148590136806 no 555 0.175681578333473 942 9550191 SGTC_320 4092-0846 5.34 µM 0.931331386445459 0.168308881897122 no 556 0.175841085591437 888 1359356 SGTC_1507 4075-3230 155 µM 0.930744107259579 0.168461523009905 no 557 0.175992974007042 812 659771 SGTC_1270 0831-1170 17.3 µM 0.929950516241573 0.168667928478841 no 558 0.176198352922459 933 6764716 SGTC_1590 st077108 57.8 µM 0.926922847475401 0.169456888569981 no 559 0.176983296858557 868 5489485 SGTC_2984 9022109 38.96 µM 0.919839328559257 0.171311970713429 no 560 0.178828363963598 877 6459207 SGTC_1142 3253-1408 9.78 µM 0.917730607853492 0.171866715768786 no 561 0.179379959619828 881 256655 SGTC_1817 st052116 64.4 µM 0.916047627642839 0.172310282638624 no 562 0.179820957494728 873 4361398 SGTC_1652 st011932 78 µM 0.915254007132496 0.172519702728005 no 563 0.180029149062176 882 1551076 SGTC_1569 carminic acid 40.6 µM 0.914480376673657 0.172724004019039 no 564 0.180232242222076 924 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1220 1838-0075 193 µM 0.913561854402305 0.172966768687901 no 565 0.180473558954504 910 5529645 SGTC_2692 st077426 47.7 µM 0.912891196237637 0.173144160326223 no 566 0.180649884096067 923 25238571 SGTC_331 k048-0133 24.5 µM 0.912035957554316 0.173370542247138 no 567 0.180874894617688 848 6813582 SGTC_3303 9125618 40.5795 µM 0.911810150339936 0.173430344909581 no 568 0.180934333062721 942 22695467 SGTC_1499 4480-0877 67.3 µM 0.911616627172123 0.173481607929889 no 569 0.18098528323039 850 2861909 SGTC_930 2810-3379 265 µM 0.910634788839228 0.173741839040317 no 570 0.181243917013538 960 1015764 SGTC_457 grayanotoxin iii 135 µM 0.91053065608622 0.173769453438736 no 571 0.181271361013841 920 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1988 st071872 53.4 µM 0.910479404226588 0.173783045665763 no 572 0.181284869305105 923 16414116 SGTC_1033 k072-0102 21.3 µM 0.908323010443597 0.174355543866221 no 573 0.181853794362342 910 5965931 SGTC_310 1273-0058 1.06 µM 0.908073348678708 0.174421903553386 no 574 0.18191973510901 1006 2734232 SGTC_2125 5246583 200 µM 0.907753565268464 0.174506924891314 no 575 0.182004218247252 980 835267 SGTC_3280 9140961 49.47 µM 0.90626407314707 0.174903285344366 no 576 0.182398048282675 864 4901226 SGTC_3088 9117578 49.47 µM 0.902504297236074 0.175906317122303 no 577 0.183394519862052 926 678341 SGTC_2800 7887935 81.82 µM 0.899214149924179 0.176787044036434 no 578 0.184269302402134 856 2961002 SGTC_2485 5633444 17.78 µM 0.896994240538061 0.177382855127589 no 579 0.18486099516073 885 5724239 SGTC_3188 9110789 49.47 µM 0.895929873995187 0.177668974189967 no 580 0.185145108844556 905 849217 SGTC_2170 morpholine 200 µM 0.895372461057694 0.177818931986812 no 581 0.185294008448901 919 121171 Reacts with secondary amines. SGTC_2529 gangaleoidin 93.61 µM 0.895364638471094 0.177821037023016 no 582 0.185296098595724 922 4565183 SGTC_445 e6 berbamine 66 µM 0.893917373162815 0.178210762527447 no 583 0.185683050824334 989 6610268 A calcium/calmodulin antagonist. SGTC_3226 9131256 49.47 µM 0.892885503000877 0.178488957220421 no 584 0.185959245653403 838 17178073 SGTC_821 1114-0266 29.2 µM 0.892391759668692 0.178622168326761 no 585 0.186091493185986 893 3123235 SGTC_2658 polymyxin b sulfate 77.05 µM 0.891433030333613 0.178881010618562 no 586 0.186348452149527 929 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1996 st072960 66.8 µM 0.891112882490828 0.178967498203893 no 587 0.186434307217829 948 1719405 SGTC_1134 3477-0009 42.5 µM 0.890983729648747 0.179002396148901 no 588 0.186468949482196 946 3973534 SGTC_1189 1431-2119 7.28 µM 0.890530873064845 0.179124794793855 no 589 0.186590449287895 952 3107275 SGTC_2086 5274770 176.623 µM 0.890464390217356 0.179142768292186 no 590 0.186608290524349 903 689278 SGTC_3150 9097574 49.47 µM 0.890270349417332 0.179195233302647 no 591 0.186660369060312 914 17217476 SGTC_1097 itavastatin 7.23 µM 0.888382263113059 0.179706241023011 no 592 0.187167581461897 949 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1655 st012546 55.1 µM 0.886570475113689 0.180197458648631 no 593 0.187655097781749 871 720985 YLR208W SEC13 SGTC_2239 6685329 187.64 µM 0.885023521877508 0.180617539764636 no 594 0.188071972568635 896 805680 SGTC_1082 camptothecin 424.86 nM 0.8825557641735 0.181288938954515 no 595 0.188738168987218 851 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1059 3448-6867 171 µM 0.882288088653717 0.181361858877332 no 596 0.188810518067282 951 3934407 SGTC_638 3970-0837 4.09 µM 0.882007689777584 0.181438264577117 no 597 0.18888632442499 907 4118451 YLR208W SEC13 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.880326083260307 0.181896907095343 no 598 0.189341343242501 965 6728940 SGTC_591 4299-0174 154 µM 0.87785714144457 0.182571600468712 no 599 0.190010625111861 936 5509088 SGTC_1975 st070967 30.8 µM 0.877642121540836 0.182630433342649 no 600 0.190068981559844 1001 261391 SGTC_1172 0370-0043 85 µM 0.877183110706515 0.182756065631306 no 601 0.190193594048246 938 376585 SGTC_3343 9148379 18.9835 µM 0.87686541001307 0.182843052606182 no 602 0.190279872977661 973 1955036 SGTC_3168 9103419 49.47 µM 0.876724803657621 0.182881559106911 no 603 0.190318065540921 875 16649256 SGTC_2461 5755302 26.15 µM 0.875687016906626 0.183165924227101 no 604 0.190600102650966 949 2788904 SGTC_2372 9071633 200 µM 0.873869198151044 0.183664691019638 no 605 0.191094745329886 1003 21321366 SGTC_1561 5-methoxyflavone 52.9 µM 0.872813390103811 0.183954768076081 no 606 0.191382399977985 920 94525 SGTC_80 0159-0065 512.242 µM 0.870184709928 0.184678220978841 no 607 0.192099735199895 883 1548079 SGTC_1843 st055809 45.5 µM 0.868170385444129 0.185233789230879 no 608 0.192650531910713 888 16413835 SGTC_12 0849-0099 9.267 µM 0.867719459807766 0.185358300485226 no 609 0.192773965060241 924 6071388 SGTC_2080 5212524 12.4 µM 0.867326511927975 0.185466845065587 no 610 0.192881567183602 931 260183 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.866006172901225 0.185831853205622 no 611 0.193243388321396 899 75037 A free radical scavenger. SGTC_1476 4112-3294 3.34 µM 0.865432246752624 0.18599065409818 no 612 0.193400794142047 975 704369 SGTC_478 N-arachidonylglycine 10 µM 0.864711823934728 0.186190108527694 no 613 0.193598489042389 854 5283389 SGTC_818 4072-2707 53.5 µM 0.861950113664458 0.186955935981424 no 614 0.194357485139293 956 882871 SGTC_863 0466-0191 129 µM 0.861451574501405 0.187094389207959 no 615 0.194494690589616 990 765160 YPR165W RHO1 SGTC_1173 0443-0020 122 µM 0.861268427200994 0.187145268408169 no 616 0.194545110275424 951 5331295 SGTC_1929 genistein trimethyl ether 50.5 µM 0.860271546320615 0.187422356734422 no 617 0.19481968687019 980 136420 SGTC_1299 1079-1439 3.74 µM 0.859425564881035 0.187657700560403 no 618 0.195052885157481 939 323161 SGTC_1438 4092-1045 4 µM 0.858612074768317 0.187884177717375 no 619 0.195277287040675 985 1351342 SGTC_404 fumagillin 50 µM 0.85854189797589 0.187903722971312 no 620 0.195296652710661 965 12015870 A methionine aminopeptidase binder. SGTC_3053 9095903 49.47 µM 0.857737222635829 0.18812792643929 no 621 0.195518790663709 1009 17174018 SGTC_2875 9039966 71.43 µM 0.856895307981524 0.188362682405911 no 622 0.195751373051421 991 6463691 SGTC_3160 9100216 49.47 µM 0.854221739034161 0.189109366486237 no 623 0.196491070120761 979 17191039 SGTC_1852 st056254 31.4 µM 0.852393107866314 0.189621121524067 no 624 0.196997972084605 961 442583 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.848330792569281 0.190761033188194 no 625 0.198126886678228 939 2346 DNA damaging agent; causes G2/M arrest. SGTC_2007 4011539 71.82 µM 0.847885923362123 0.190886121298035 no 626 0.198250752375673 951 45595301 SGTC_8 0354-0001 70 µM 0.846613499654476 0.191244178491491 no 627 0.19860529344932 1056 4993152 SGTC_315 k915-0449 187 µM 0.845459287705747 0.19156932702398 no 628 0.198927227191878 1031 20970215 YNL149C PGA2 SGTC_302 1094-0063 18.9 µM 0.84463091315297 0.191802893781329 no 629 0.199158471845874 914 5440289 SGTC_1710 st031758 61.5 µM 0.843036295687066 0.192252999382977 no 630 0.199604072436234 965 5394341 SGTC_1970 st070122 35.8 µM 0.842418269943782 0.192427620351469 no 631 0.199776935015264 974 102928 SGTC_715 0868-0130 184 µM 0.841870737674843 0.192582404627289 no 632 0.199930155686688 988 2876258 SGTC_449 xestospongin c 11.1929 µM 0.840043075715149 0.193099625058068 no 633 0.200442117468788 981 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_3191 9110352 49.47 µM 0.839785969218031 0.193172453068351 no 634 0.200514200859143 967 17122424 SGTC_1751 st044839 27.194 µM 0.839304136319683 0.193308982246799 no 635 0.200649331346705 999 5291326 SGTC_2207 7258803 200 µM 0.838695330152883 0.193481573965176 no 636 0.200820149766875 960 3666799 SGTC_1938 st074717 56.4 µM 0.838033639780633 0.193669264501649 no 637 0.201005905340172 915 17250979 SGTC_2376 9072922 81.32 µM 0.837946810806345 0.193693902048358 no 638 0.201030288385545 992 17087968 SGTC_1143 3454-2408 5.08 µM 0.837665353806568 0.193773778042147 no 639 0.201109338470001 955 X1143 SGTC_2989 9073649 71.4286 µM 0.835693558025795 0.194333926084747 no 640 0.201663660130336 1041 21367202 SGTC_104 0074-0074 590.992 µM 0.835623979913508 0.19435370983712 no 641 0.201683236999349 855 3943124 SGTC_3162 9099653 49.47 µM 0.834184696742628 0.194763228783136 no 642 0.202088456656816 967 25237511 SGTC_1170 0310-0127 64.8 µM 0.833962240807798 0.194826570925427 no 643 0.202151130941243 995 774975 SGTC_3023 9089636 49.47 µM 0.833477016619493 0.194964777210595 no 644 0.202287877364035 1075 17249241 SGTC_1222 0366-0074 1.18 µM 0.832747264232789 0.195172744610621 no 645 0.202493641145939 1044 286520 SGTC_2643 anethole 100 µM 0.830532880796067 0.195804632164013 no 646 0.203118782683551 1033 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1691 st019933 84.6 µM 0.829704028202059 0.19604146918919 no 647 0.203353071698804 1001 6176082 SGTC_1954 st077032 68.9 µM 0.827575817430829 0.196650381296697 no 648 0.203955384093635 936 698907 SGTC_3316 9136639 10.545 µM 0.827239742903325 0.196746641751823 no 649 0.20405059481848 991 4903665 SGTC_1799 st045822 46.1415 µM 0.827140930515144 0.196774949608628 no 650 0.204078593642876 991 3674992 SGTC_2067 5224629 34.075 µM 0.826824238529981 0.196865692416514 no 651 0.204168344808416 1008 2835000 SGTC_1763 st044482 94.5 µM 0.826003519560492 0.197100973635981 no 652 0.204401047644118 1009 88505 SGTC_318 1488-0629 67.2 µM 0.825463817481765 0.197255786489003 no 653 0.204554158268992 962 3662576 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.823458512390525 0.197831649816907 no 654 0.205123650305943 1004 97141 SGTC_903 1134-0042 114 µM 0.820971799607644 0.198547167983165 no 655 0.205831165745305 987 701009 SGTC_1100 amiodarone 5.07 µM 0.819204900929866 0.199056516670588 no 656 0.206334759601523 1059 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2695 st077686 51.995 µM 0.819094235665388 0.199088444624912 no 657 0.206366325218845 999 2876092 SGTC_2728 chlorpromazine 9.18 µM 0.818581709065835 0.199236353527508 no 658 0.20651255310398 970 2726 A thorazine and dopamine antagonist. SGTC_2971 9092186 9.93 µM 0.818526922768053 0.199252168096761 no 659 0.206528187697694 925 25236400 SGTC_721 1187-1332 279 µM 0.816395672534046 0.199867959671238 no 660 0.207136935441587 911 25730 SGTC_1732 st034308 51.822 µM 0.814804787989386 0.200328366181741 no 661 0.207592029910603 957 830119 SGTC_450 aminopyrene 156 nM 0.814451512694532 0.200430691447797 no 662 0.207693169291914 1010 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2046 4110841 106 µM 0.81428662381415 0.200478461825331 no 663 0.207740385384143 1032 44119630 YMR134W ERG29 SGTC_1044 1222-0021 1.78 µM 0.814188973585273 0.200506755545531 no 664 0.207768350611867 977 4306703 SGTC_1211 1056-0033 32.3 µM 0.813264566707334 0.20077471711766 no 665 0.208033193862876 1036 6741922 SGTC_790 1575-0012 79.1 µM 0.813253072928001 0.20077805021836 no 666 0.208036488092945 1058 378741 YLR208W SEC13 SGTC_487 nimodipine 119 µM 0.812382078490491 0.201030727986769 no 667 0.208286213224916 945 4497 L-type voltage-gated calcium channels inhibitor SGTC_3230 9131665 49.47 µM 0.8093184524668 0.201921008175663 no 668 0.209165997490622 975 15943720 SGTC_892 0929-0076 29 µM 0.806805746890534 0.202652951339797 no 669 0.209889203824705 1051 5751038 SGTC_425 3825-7017 13.1 µM 0.805936381229057 0.202906563560794 no 670 0.210139766259526 1042 3397440 SGTC_2778 tioconazole 65.09 nM 0.80565862704169 0.202987630232152 no 671 0.210219855631538 993 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1903 st060211 78.3 µM 0.805478837285058 0.203040114844725 no 672 0.210271706885806 1066 688960 SGTC_876 0720-0963 56.8 µM 0.805254198348202 0.203105703312537 no 673 0.210336503168781 1057 765861 SGTC_2634 4'-methoxyflavone 100 µM 0.804830397132237 0.203229476193652 no 674 0.210458779002967 984 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1367 1812-0510 76.9 µM 0.803687033047947 0.20356362484901 no 675 0.210788872373078 1026 1142582 YDR527W RBA50 SGTC_1414 3917-0015 5.4 µM 0.802934067515781 0.20378385819347 no 676 0.211006421999303 1040 6618702 SGTC_1682 st012968 530 nM 0.80244218836071 0.203927803585743 no 677 0.211148608618489 953 24207270 SGTC_1673 st016611 27.3 µM 0.800112631664951 0.204610356515485 no 678 0.21182277161151 1047 5226799 SGTC_1851 st056236 18.9 µM 0.79953747164013 0.204779085620715 no 679 0.211989413930216 1086 5393171 SGTC_476 mead acid 10 µM 0.798940937603168 0.204954172406329 no 680 0.212162329961674 1038 5312531 An omega 9 fatty acid. SGTC_1920 st075728 45.7 µM 0.797122873241887 0.205488335299247 no 681 0.212689836696178 1016 3400306 SGTC_693 4161-2696 114 µM 0.79553511877026 0.205955506678153 no 682 0.213151145423074 1010 805759 SGTC_1735 st034310 56.75 µM 0.794282523064464 0.20632450709794 no 683 0.213515488035472 1006 871153 SGTC_3055 9094636 49.47 µM 0.794140678764135 0.206366317494393 no 684 0.213556769162071 1049 25236176 SGTC_2217 6934799 96.0675 µM 0.792776709469287 0.20676862084708 no 685 0.213953964190476 1044 675606 SGTC_1101 ebselen 5.29 µM 0.79154339167195 0.207132787905986 no 686 0.21431348277937 1134 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_224 benfluorex 43.875 µM 0.790775151491007 0.207359821139508 no 687 0.214537606311138 1051 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1679 SEC14.276 6.7 µM 0.790342916293673 0.207487621562525 no 688 0.214663764873749 1095 1005053 YMR079W SEC14 SGTC_85 0868-0259 160.055 µM 0.78975379218354 0.207661884801989 no 689 0.214835784768124 986 83173 SGTC_259 usnic acid 108.925 µM 0.789355221297544 0.207779831316604 no 690 0.21495220992883 1084 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3259 9138485 49.47 µM 0.785020909534524 0.209065008989856 no 691 0.216220654596332 1156 17646153 SGTC_1807 st050092 58.9 µM 0.783298436859041 0.209577040706099 no 692 0.216725940473308 1040 5008496 SGTC_2956 9076196 2.52 µM 0.782303759333782 0.209873059685067 no 693 0.217018039027785 1070 16423868 SGTC_366 0181-0206 4.31 µM 0.781436819312411 0.210131263936257 no 694 0.21727281144747 1074 274874 SGTC_2856 9022925 19.48 µM 0.781309452682147 0.210169213769752 no 695 0.217310255925789 1042 4944862 SGTC_374 0880-0231 82.3 µM 0.781159035571889 0.210214036849043 no 696 0.217354481806951 1059 6833587 SGTC_2541 muurolladie-3-one 83.07 µM 0.78093132634349 0.210281903034849 no 697 0.217421443129654 1014 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2511 berberine 10.47 µM 0.778708782675574 0.210944982633415 no 698 0.218075640661773 1034 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1122 capsaicin 818.572 nM 0.778400605544182 0.211037021697776 no 699 0.21816644095173 1073 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1021 4476-0760 85.3 µM 0.777817466537354 0.211211244277955 no 700 0.218338314705365 1073 746768 SGTC_2964 9083345 53.42 µM 0.777481992233828 0.211311511040865 no 701 0.218437227369076 1040 17741579 SGTC_570 0987-0065 62.6 µM 0.774408490689012 0.212231418183228 no 702 0.219344632081258 978 3104428 SGTC_245 methotrexate 289.6 µM 0.772889802992321 0.212686828180222 no 703 0.219793800003971 1075 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1230 0170-0365 3.77 µM 0.772619091443704 0.212768066531497 no 704 0.219873921213366 1174 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_859 0439-0102 54.6 µM 0.771964843181083 0.212964475932433 no 705 0.220067625152039 1128 610143 SGTC_1194 1488-0194 225 µM 0.771373039145929 0.213142230285982 no 706 0.220242925458809 1069 1391452 SGTC_2025 5147754 141 µM 0.768250932099442 0.214081418294073 no 707 0.221169059931518 1076 315777 YLR208W SEC13 SGTC_3201 9113999 49.47 µM 0.765722279262392 0.214843846409096 no 708 0.221920783825962 1039 16649224 SGTC_1555 citronellol 128 µM 0.765472216988404 0.214919329681631 no 709 0.221995202125665 1069 8842 A terpine precursor. SGTC_3222 9128301 49.47 µM 0.764207992371115 0.215301181582774 no 710 0.222371652228236 1125 4911358 SGTC_1588 farnesol 29.9 µM 0.764122853806385 0.215326911346597 no 711 0.222397017149635 1064 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2909 7941780 10.49 µM 0.763797347556647 0.215425299185511 no 712 0.222494008869159 1108 1243215 SGTC_2355 9061122 103.12 µM 0.763624906416817 0.215477431979682 no 713 0.222545401257946 1090 5302957 SGTC_2033 5192550 145 µM 0.762700906724653 0.215756902282557 no 714 0.222820894852879 1098 182073 SGTC_1418 3966-3099 2.4 µM 0.762071004113624 0.215947541201874 no 715 0.223008813757079 1100 740335 SGTC_1784 st039334 36.3 µM 0.761090212905531 0.216244570141889 no 716 0.223301592897981 1087 3496984 SGTC_1387 3342-1166 1.8 µM 0.76103244418328 0.216262072556241 no 717 0.223318844444375 1040 3418228 SGTC_2813 7971799 71.43 µM 0.760730302900621 0.216353626836555 no 718 0.22340908563343 1069 2234054 SGTC_3161 9100388 49.47 µM 0.760270723177048 0.21649293082301 no 719 0.223546389074567 1133 25236368 SGTC_2420 aureobasidin a 50 nM 0.758844983204296 0.216925419378934 no 720 0.223972646565227 1114 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1937 st074714 47.2 µM 0.758774568840399 0.216946792032483 no 721 0.223993710505856 1102 17250970 SGTC_533 1222-0222 6.71 µM 0.758291961400613 0.217093309126834 no 722 0.22413810927098 1146 3982874 SGTC_2519 cryptotanshinone 88.04 µM 0.758180068398769 0.217127287419744 no 723 0.224171595812533 1089 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1036 k216-0215 33.5 µM 0.757135959972198 0.217444497516721 no 724 0.22448420607103 1094 622330 SGTC_3301 9125354 19.7965 µM 0.75550147339432 0.217941606964542 no 725 0.224974074299241 1054 41905162 SGTC_810 3825-7150 143 µM 0.754399620065681 0.218277091869297 no 726 0.225304649829431 1159 22330411 YGL099W LSG1 SGTC_658 3253-0951 102 µM 0.754389747445772 0.218280099162625 no 727 0.225307613033259 1133 1184878 SGTC_2690 usnic acid 100 µM 0.753915245598904 0.218424665052098 no 728 0.225450057751038 1152 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1228 0124-0032 52.5 µM 0.753378721381931 0.218588193627764 no 729 0.225611182881929 1142 X1228 SGTC_1567 st069303 68.4 µM 0.752609064378432 0.218822902371829 no 730 0.225842434533976 1122 5581319 SGTC_2545 solidagenone 89.61 µM 0.750350311441585 0.219512551125782 no 731 0.226521874347969 938 6708572 An anti ulcer agent SGTC_2932 9016711 44.54 µM 0.748098837645213 0.220201218228492 no 732 0.227200271539054 1125 7117328 SGTC_1785 bathophenanthroline 24 µM 0.747234926499837 0.220465794669554 no 733 0.227460882439563 1045 72812 An iron chelator. SGTC_1870 st057514 26.5 µM 0.744807396785506 0.221210210326262 no 734 0.228194081336787 1129 5393161 SGTC_2895 9054447 58.44 µM 0.740989656015144 0.222383845960709 no 735 0.22934985610108 1149 2697450 SGTC_48 0382-0018 55 µM 0.740492820541882 0.222536842026979 no 736 0.229500507959677 1210 762596 SGTC_1765 st044815 90.4 µM 0.73760117935216 0.223428487495783 no 737 0.230378419274413 1126 645695 SGTC_1678 st019265 80.2 µM 0.73672170125845 0.223700079542461 no 738 0.230645803484663 1154 5367020 SGTC_1435 4092-0789 56.7 µM 0.735851450358608 0.223969006797328 no 739 0.230910552973088 1135 2248285 SGTC_3165 9101544 49.47 µM 0.735689712591249 0.224019007668092 no 740 0.230959775855039 1117 5002184 SGTC_1113 artemisinin 1.17947 µM 0.733832434688981 0.224593635334572 no 741 0.231525435002789 1150 2240 An anti-malaria and mitochondrial poison. SGTC_668 1682-0499 62.6 µM 0.73242402201003 0.225029944413635 no 742 0.231954900548462 1160 682214 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.731849566242222 0.2252080416234 no 743 0.232130195925451 1143 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1983 st071813 46.9 µM 0.731628379594562 0.225276636897854 no 744 0.23219771076428 1100 11838595 SGTC_815 1582-0027 36.9 µM 0.731407519155877 0.22534514281194 no 745 0.232265136933748 1156 3128206 SGTC_31 0508-1974 57.237 µM 0.730961388610037 0.225483558392822 no 746 0.232401368716905 1118 6810525 SGTC_2155 5570423 76 µM 0.729822688414472 0.225837067353435 no 747 0.232749287088609 1090 797402 SGTC_2970 9090938 41.86 µM 0.727620512488218 0.22652162031623 no 748 0.233422960199437 1172 17217104 SGTC_265 mycophenolic acid 32.932 µM 0.726884371772704 0.226750712845594 no 749 0.233648395835125 1226 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_894 0960-0238 55.9 µM 0.725165291175656 0.227286212458684 no 750 0.234175316644758 1144 6741907 YDL195W SEC31 SGTC_2928 9011484 9.79 µM 0.72472009409241 0.227425008988726 no 751 0.23431188258503 1126 2994751 SGTC_887 0885-0007 9.62 µM 0.724082639248723 0.227623827711939 no 752 0.23450750106467 1164 5719458 SGTC_11 0438-0307 1.3 µM 0.724030096442675 0.227640219893711 no 753 0.234523629128434 1150 4011476 SGTC_130 0136-0219 337.655 µM 0.723564340782215 0.227785554308615 no 754 0.234666620089437 1109 234244 SGTC_2684 capsaicin 100 µM 0.723063214104731 0.227941984199129 no 755 0.234820524079967 1152 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_464 bw-b 70c 158 µM 0.722543703494015 0.228104216533446 no 756 0.234980132952629 1186 5353454 SGTC_666 0272-0154 136 µM 0.720882654329556 0.228623363015303 no 757 0.235490857890842 1176 6870312 SGTC_2374 9071832 200 µM 0.717811491581395 0.229584973605982 no 758 0.236436763405887 1132 17381698 SGTC_1558 st069300 45.6 µM 0.717315112271946 0.229740607177063 no 759 0.236589842277137 1106 24208000 SGTC_1290 0986-0249 10.2 µM 0.717210986962074 0.229773261870693 no 760 0.236621960494937 1135 53329 SGTC_1185 1319-0113 81.3 µM 0.714875107441547 0.230506498823646 no 761 0.237343109875298 1153 4672763 SGTC_1756 st041558 35.5 µM 0.714213059521392 0.230714554515009 no 762 0.23754772131705 1253 3955792 SGTC_944 3370-0224 231 µM 0.7135417755293 0.230925619809389 no 763 0.2377552860503 1187 4580514 SGTC_1953 st076800 12.1 µM 0.712794063498838 0.231160842491726 no 764 0.237986599827687 1134 297591 SGTC_1385 3091-4834 14.1 µM 0.710730693993267 0.231810650799244 no 765 0.23862556768093 1117 4072814 SGTC_3147 9097027 49.47 µM 0.710216893651398 0.231972617882469 no 766 0.23878482316099 1183 25236841 SGTC_2179 6298986 200 µM 0.710050515966504 0.232025079206768 no 767 0.238836405375914 1117 738374 SGTC_795 0685-0265 78 µM 0.708296900986662 0.232578421268033 no 768 0.239380450595566 1232 302754 SGTC_1268 0828-0275 2.46 µM 0.706055525361692 0.233286740006952 no 769 0.240076804029319 1218 745337 SGTC_846 0335-0850 148 µM 0.705278653958775 0.233532525723687 no 770 0.240318420893456 1167 6819598 SGTC_312 4092-0653 6.84 µM 0.704719548309918 0.233709503786848 no 771 0.240492391793727 1195 1148278 SGTC_2079 5212404 121 µM 0.702729666774638 0.234339979266165 no 772 0.241112117894711 1187 758462 SGTC_2251 lansoprazole 556 µM 0.702714762071995 0.234344705231778 no 773 0.24111676306944 1046 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2799 7812892 81.82 µM 0.70107513236489 0.234864919040489 no 774 0.241628064274262 1183 20205235 SGTC_991 3996-0057 64.7 µM 0.699164636726458 0.235471876153 no 775 0.242224573940797 1155 715343 SGTC_2811 7967822 32.47 µM 0.699036566950794 0.235512594360571 no 776 0.242264589400758 1185 2232244 SGTC_3311 9131146 2.8755 µM 0.698988105625664 0.235528003055042 no 777 0.242279732098271 1153 4900406 YPR165W RHO1 SGTC_2553 4-methylesculetin 85.09 µM 0.698863582011596 0.235567598958194 no 778 0.242318644311575 1208 5319502 SGTC_1167 k781-0610 148 µM 0.698112024141877 0.235806656582865 no 779 0.242553569487016 1208 4525169 SGTC_1883 5-benzylidenerhodanine 20 µM 0.698072053226982 0.235819374387885 no 780 0.242566067220186 1191 1273210 SGTC_853 0419-0306 21 µM 0.697659023220586 0.23595081296199 no 781 0.242695230011051 1147 762713 SGTC_704 1310-0270 142 µM 0.697585284369752 0.235974283129654 no 782 0.24271829354932 1182 5718033 SGTC_1163 k060-0048 49.9 µM 0.695958764244817 0.236492311494052 no 783 0.243227327086191 1207 6809982 SGTC_851 0394-0702 453 µM 0.695099191587582 0.236766328286146 no 784 0.243496570681041 1201 762646 SGTC_362 0310-0100 9.03 µM 0.69481361497904 0.236857403761592 no 785 0.243586057343204 1213 790235 SGTC_170 4197-0004 226 µM 0.694289618294811 0.237024565738754 no 786 0.243750300146898 1187 218692 SGTC_1348 1493-0373 93.8 µM 0.693495071361335 0.237278160524152 no 787 0.243999458890354 1190 3010129 SGTC_2911 7942208 15.64 µM 0.692385830786102 0.237632444872832 no 788 0.244347530801441 1188 1243384 SGTC_689 0833-0039 98 µM 0.691401635388134 0.237947033456153 no 789 0.244656588327894 1203 5374726 SGTC_2334 9017922 200 µM 0.691326375087145 0.237971099080749 no 790 0.24468023026562 1217 3163164 SGTC_3218 9131285 49.47 µM 0.690766789722802 0.238150076839946 no 791 0.244856054505517 1214 17156417 SGTC_2121 5257820 149.641 µM 0.690266978862771 0.238309998666174 no 792 0.245013154800749 1243 791256 SGTC_2650 prasterone 100 µM 0.689107801192345 0.238681120886101 no 793 0.245377715555537 1161 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2497 7-hydroxyflavone 100 µM 0.688674672021969 0.2388198726 no 794 0.245514009225165 1174 5281894 SGTC_1508 1080-0625 72.9 µM 0.687622819221515 0.23915701429047 no 795 0.245845167209132 1155 767111 SGTC_2 0422-0095 29 µM 0.687583041686228 0.239169768957392 no 796 0.245857695193414 1106 6790840 SGTC_1247 0448-0043 5.84 µM 0.686393122247385 0.239551488466622 no 797 0.24623262019441 1231 3089013 YGL099W LSG1 SGTC_2756 carbadox 75.1 µM 0.686039012061145 0.239665149219536 no 798 0.246344253935513 1209 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.685680853575685 0.239780139310673 no 799 0.246457191498436 1201 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1840 st055363 71 µM 0.685263607926974 0.239914137832869 no 800 0.246588795905595 1159 676033 SGTC_697 0508-1955 564 µM 0.684882790944932 0.240036472921615 no 801 0.246708943112708 1206 6243113 SGTC_2629 bisabolol 100 µM 0.683942363360699 0.240338725087779 no 802 0.247005780896778 1215 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_488 nitrendipine 139 µM 0.682766091376802 0.24071706900439 no 803 0.247377329734561 1240 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2716 st080858 38.6235 µM 0.681889274183799 0.240999305029643 no 804 0.247654484048511 1205 5296050 SGTC_2887 9044784 58.44 µM 0.681467441739936 0.241135151483354 no 805 0.24778788068957 1231 6465546 SGTC_1832 st054113 55 µM 0.678893234749854 0.241965047664136 no 806 0.248602756297114 1206 1251267 SGTC_548 1436-0017 110 µM 0.67858615659417 0.242064149628746 no 807 0.248700058338704 1273 9677137 SGTC_67 0335-0847 266 µM 0.677492213942568 0.242417371669945 no 808 0.249046854242098 1282 4552207 YOR254C SEC63 SGTC_590 k048-0076 22.4 µM 0.676898542725497 0.242609178397692 no 809 0.249235164390323 1221 6832814 SGTC_385 1494-0393 12.4 µM 0.676160297465308 0.242847809529156 no 810 0.249469438426896 1241 3090647 SGTC_2050 5263056 171 µM 0.675627520383471 0.243020103799165 no 811 0.24963858206373 1232 763468 YGL055W OLE1 SGTC_284 0988-0104 32.6 µM 0.675506984655634 0.243059092901938 no 812 0.249676857644525 1240 4666532 SGTC_586 0957-0265 8.15 µM 0.675491373255487 0.243064142892685 no 813 0.249681815202731 1138 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2279 7948423 32.93 µM 0.675219717510915 0.243152027438546 no 814 0.249768090604733 1234 1247112 SGTC_2625 euphol 100 µM 0.675031210614494 0.243213022230811 no 815 0.249827967988174 1224 6708538 A triterpene alcohol. SGTC_109 0132-0036 33.701 µM 0.674547085384555 0.243369707537415 no 816 0.249981780572616 1112 67274 A color developer. SGTC_782 0083-0095 30.5 µM 0.674344950601942 0.243435143836325 no 817 0.250046016165658 1243 3591729 An indicator and reagent. SGTC_1881 5652484 16 µM 0.673316651597831 0.243768178165336 no 818 0.250372930686391 1197 2255129 SGTC_604 1000-0114 314 µM 0.673108290938753 0.243835689708661 no 819 0.250439199835491 1265 1572745 SGTC_1608 st001473 40.5 µM 0.673005797032671 0.243868902759707 no 820 0.250471801453466 1193 7292267 SGTC_1453 4237-0541 195 µM 0.672437028660105 0.244053255956205 no 821 0.2506527581366 1200 739892 SGTC_1788 fluconazole 20 µM 0.671870090073185 0.244237090850182 no 822 0.250833201552141 1213 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2676 harmalol 100 µM 0.671372142330334 0.244398616406267 no 823 0.250991743487821 1237 5459187 A monoamine oxidase inhibitor SGTC_486 niguldipine 82 µM 0.670277892189049 0.244753774201677 no 824 0.251340328780546 1236 1236 A calcium channel blocker. SGTC_2077 5212015 200 µM 0.669996150202502 0.244845263391694 no 825 0.251430122170331 1156 780900 SGTC_396 dithiazanine 1.25 µM 0.669192004043247 0.245106492456832 no 826 0.251686503109136 1216 10578 An antihelmenthic. SGTC_480 am 92016 50 µM 0.667799069997742 0.245559345350844 no 827 0.252130930150976 1170 2129 K+ channel blocker. SGTC_1305 1181-0477 144 µM 0.667793194798221 0.24556125637191 no 828 0.252132805557878 1245 6252086 SGTC_2705 st078069 42.8 µM 0.667436643410219 0.245677246485874 no 829 0.252246633155151 1215 1530061 SGTC_585 0kpi-0023 191 µM 0.666449662239154 0.245998475768868 no 830 0.252561864192546 1201 64601 SGTC_2379 9035213 200 µM 0.665115786746519 0.246432965349075 no 831 0.252988219048905 1263 646551 SGTC_3069 9117009 49.47 µM 0.665033316812939 0.246459842163628 no 832 0.25301459184881 1129 41904981 SGTC_358 0075-0058 9.45 µM 0.664800251720316 0.246535806181822 no 833 0.253089130819309 1260 1069125 SGTC_3172 9105863 49.47 µM 0.663399313974048 0.246992684696796 no 834 0.253537422579304 1227 2348785 SGTC_1493 4348-0038 111 µM 0.661802861423422 0.247513876934181 no 835 0.254048786033152 1287 800424 SGTC_1857 st056007 79.3 µM 0.661623841104085 0.247572358134843 no 836 0.254106162171099 1259 619834 SGTC_536 3852-0578 10.6 µM 0.66053703447111 0.247927547475111 no 837 0.25445463029074 1262 2869208 SGTC_174 3553-0389 74.3 µM 0.659881615511542 0.248141882403413 no 838 0.254664901452527 1239 738071 SGTC_2097 5376186 200 µM 0.659343990676626 0.248317770086007 no 839 0.254837449877065 1215 742755 SGTC_1875 nocodazole 6 µM 0.657485751360976 0.248926217454646 no 840 0.255434314919345 1245 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2824 7998404 51.95 µM 0.656727347744417 0.249174771022351 no 841 0.255678123317668 1242 837851 SGTC_135 0933-0004 26.348 µM 0.65618199257099 0.249353583226735 no 842 0.255853516878779 1229 21230617 YGL099W LSG1 SGTC_2753 fluvastatin 17.09 µM 0.654213209228997 0.249999679274407 no 843 0.256487226262821 1274 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1269 0831-0796 3.05 µM 0.653173474092467 0.25034124747703 no 844 0.256822224487324 1251 927758 SGTC_1645 Cervolide 78 µM 0.652895070543427 0.250432749088609 no 845 0.256911963559449 1211 23173 A fragrance. SGTC_71 0417-1750 47.813 µM 0.652710856471661 0.250493303621799 no 846 0.256971351080813 1259 6811472 SGTC_1819 st053448 58.6 µM 0.651898019759035 0.250760590532071 no 847 0.257233481235726 1225 2857616 SGTC_2896 9052656 71.43 µM 0.650389737626319 0.251256962137415 no 848 0.257720252270738 1240 6469436 SGTC_771 0250-0039 27.3 µM 0.648916237135655 0.251742388444857 no 849 0.258196259502871 1264 3005115 SGTC_720 r052-1644 49.9 µM 0.648598773501648 0.251847037672369 no 850 0.25829887424288 1245 1422863 YOR257W CDC31 SGTC_296 1222-0039 74.9 µM 0.64739685273531 0.252243448750879 no 851 0.258687566160278 1232 5984176 SGTC_3103 9120822 49.47 µM 0.647059791980476 0.252354675368267 no 852 0.258796623348685 1334 17141819 SGTC_1748 st037455 53.6035 µM 0.646684028086546 0.252478704098012 no 853 0.258918231114835 1271 580690 SGTC_868 0527-0199 213 µM 0.64665048572547 0.252489777017056 no 854 0.258929087803381 1251 2849450 SGTC_619 1652-1634 108 µM 0.645346742101505 0.252920363745358 no 855 0.259351254155928 1238 5400454 SGTC_1635 st007035 42.4 µM 0.644627212747583 0.253158167725129 no 856 0.259584397780197 1300 3716403 SGTC_692 k241-0027 77.8 µM 0.643820723568954 0.253424851577967 no 857 0.259845846893756 1343 3600480 SGTC_2208 7283366 200 µM 0.64297183157407 0.253705716288786 no 858 0.260121188912083 1280 898663 SGTC_398 bronopol 33.3 µM 0.64158775422819 0.254164002903516 no 859 0.260570443066956 1229 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2266 7929956 200 µM 0.641422569096632 0.254218726905977 no 860 0.260624086758902 1277 2967153 SGTC_761 k216-0224 480 µM 0.641371436572616 0.254235667796375 no 861 0.260640693142602 1322 1340404 SGTC_685 1278-0033 54.9 µM 0.640606667781127 0.254489116563094 no 862 0.260889133181616 1347 3590572 SGTC_508 roscovitine 141 µM 0.640397332417067 0.254558514575081 no 863 0.260957158341725 1329 160355 A CDKinase inhibitor. SGTC_3246 9135460 32.98 µM 0.640013028737908 0.254685943175397 no 864 0.261082064559476 1229 41446951 SGTC_3019 9081971 49.47 µM 0.63970121863213 0.254789358674164 no 865 0.261183431525805 1322 16451803 SGTC_2648 atorvastatin 78.68 µM 0.638162579364944 0.255299988235037 no 866 0.261683926789076 1293 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2260 7964312 200 µM 0.637726201406039 0.25544490668548 no 867 0.261825963234918 1320 231951 SGTC_2417 cerulenin 830 nM 0.636753574756779 0.25576806465077 no 868 0.262142685230488 1365 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_3063 1327-0034 4 µM 0.636074305810895 0.255993880195014 no 869 0.262363995852453 1206 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1396 3511-0007 98.6 µM 0.635652087941012 0.256134294317107 no 870 0.262501605621636 1249 X1396 SGTC_212 3807-4682 38.772 µM 0.633288193302442 0.256921179974537 no 871 0.263272730983209 1366 3125501 YBL034C STU1 SGTC_1772 st048439 82.2 µM 0.631976299311268 0.257358421144366 no 872 0.263701182168289 1270 2927068 YDL195W SEC31 SGTC_2309 7664088 163.95 µM 0.631792577756964 0.257419684558154 no 873 0.263761212130857 1306 704922 SGTC_1464 k208-0027 110 µM 0.631438012456842 0.257537938596898 no 874 0.263877084005949 1362 X1464 SGTC_2064 5220758 200 µM 0.631170354603984 0.257627226091572 no 875 0.263964571728985 1331 788518 SGTC_786 4544-0069 423 µM 0.630165959662154 0.257962423643268 no 876 0.264293004075663 1354 748821 YLR208W SEC13 SGTC_837 0091-0265 12.5 µM 0.630157469442778 0.257965258055169 no 877 0.264295781223416 1266 759367 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.629941365687694 0.258037408514806 no 878 0.264366473687084 1318 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2607 solasodine 47.35 µM 0.629870906188586 0.258060935057123 no 879 0.264389524675747 1301 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_597 k018-0003 82.8 µM 0.629145517047367 0.258303208344407 no 880 0.264626896886025 1373 6786234 SGTC_2986 9022445 71.43 µM 0.629086669696905 0.258322867984991 no 881 0.264646158510514 1280 6459286 SGTC_1880 MG-132 525 µM 0.62723825045035 0.258940779762024 no 882 0.265251536739141 1257 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2276 7947513 42.08 µM 0.624932761300596 0.259712556501164 no 883 0.266007594629045 1161 2105100 SGTC_2675 theaflavin digallate 100 µM 0.624707406106396 0.259788059190101 no 884 0.266081555722835 1307 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2319 6033012 152.6 µM 0.624044625160971 0.260010182012509 no 885 0.266299139353998 1257 847246 SGTC_682 0kpi-0099 17 µM 0.623483004921092 0.260198478702329 no 886 0.266483583502964 1309 1714895 YML126C ERG13 SGTC_773 4358-1457 44.6 µM 0.622970955221568 0.260370216904183 no 887 0.266651804271554 1316 1186886 SGTC_1643 st009866 20.2 µM 0.62170278560016 0.260795804146662 no 888 0.267068659810536 1301 3156273 YOR207C RET1 SGTC_3087 9117406 49.47 µM 0.621124340925377 0.26099004418235 no 889 0.267258907519866 1290 42546093 SGTC_1376 2910-0861 41.3 µM 0.619641429282579 0.261488341160208 no 890 0.267746942316891 1356 1112859 SGTC_410 α-linolenic acid 100 µM 0.619465631927662 0.261547446024699 no 891 0.26780482800184 1337 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_753 1322-0200 289 µM 0.618886638825809 0.261742157891107 no 892 0.267995520558177 1325 5403907 SGTC_214 4373-3496 70 µM 0.616547739709047 0.262529471767781 no 893 0.268766536999187 1382 3779166 SGTC_132 0417-1715 25.805 µM 0.614396728010915 0.2632546080136 no 894 0.269476598707536 1356 6769098 SGTC_1941 st076221 61.8 µM 0.613659490306159 0.263503376380639 no 895 0.269720181419327 1312 2828568 SGTC_509 pifithrin 175 µM 0.612593337204381 0.263863343761877 no 896 0.270072632436671 1399 4817 A p53 inhibitor. SGTC_2833 9001315 45.46 µM 0.612307760402075 0.263959806175088 no 897 0.270167078095482 1362 2989378 SGTC_1908 st060353 56.5 µM 0.612305456272884 0.263960584539199 no 898 0.27016784018183 1388 4227716 SGTC_492 tmb-8 126 µM 0.611650991346448 0.264181718451387 no 899 0.270384346726846 1238 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1462 k081-0014 26.5 µM 0.6115585690543 0.264212954163547 no 900 0.270414928355857 1136 3270634 SGTC_588 3970-1144 52.9 µM 0.607202449011894 0.265687310682732 no 901 0.271858283594305 1276 1888707 SGTC_611 3453-1652 23.7 µM 0.604508904764772 0.266601040454193 no 902 0.272752675358533 1353 1560575 SGTC_1718 roemerine 11.9335 µM 0.603811304468623 0.266837945864676 no 903 0.272984551425549 1281 235224 An aporphine alkaloid with mutagenic activity. SGTC_2100 5377183 190 µM 0.601443174215005 0.267642956729316 no 904 0.27377242490936 1363 2844202 SGTC_2552 juarezic acid 87.02 µM 0.601252048506426 0.267707980432418 no 905 0.27383606116484 1365 1549512 SGTC_647 0140-0236 81 µM 0.601163735212377 0.26773802856867 no 906 0.273865467985825 1350 990837 SGTC_281 1672-3440 14.9 µM 0.601089574203518 0.267763262776647 no 907 0.273890163543201 1341 6833000 SGTC_1205 4161-2785 76 µM 0.599805840507349 0.268200258991381 no 908 0.274317820238211 1302 3498106 SGTC_1520 flindersine 88 µM 0.597164811973476 0.269100419551006 no 909 0.275198674909778 1487 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_418 lividomycin a 100 µM 0.596984972430433 0.269161770630066 no 910 0.275258706881257 1333 72394 An antibiotic. SGTC_2583 asiatic acid 100 µM 0.595921741189086 0.26952462830991 no 911 0.275613754182754 1342 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1607 st000305 50.6 µM 0.595614183689126 0.269629636684125 no 912 0.275716499552928 1395 5457690 SGTC_1930 st074634 34.3 µM 0.595587230611838 0.269638840163873 no 913 0.275725504632738 1317 684253 YOR116C RPO31 SGTC_1478 0453-0656 35.7 µM 0.595424445297098 0.269694428677926 no 914 0.275779894621661 1355 5258496 SGTC_983 1491-0821 12.2 µM 0.592880034289674 0.270564048647357 no 915 0.276630720348414 1354 46495113 SGTC_2302 7771753 200 µM 0.592024841647286 0.270856647622627 no 916 0.276916976847168 1298 2203047 SGTC_2245 6637752 200 µM 0.59084408441461 0.271260895929052 no 917 0.277312446993597 1340 681890 SGTC_1824 st053723 68.6 µM 0.589537026078547 0.271708735572772 no 918 0.27775054091545 1318 675225 SGTC_2164 5685496 200 µM 0.58945655030096 0.271736321149566 no 919 0.277777525465304 1349 759046 SGTC_1969 st069479 40.1 µM 0.589298542352634 0.271790487345359 no 920 0.277830511260246 1393 3895485 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.588580796208476 0.272036603207065 no 921 0.278071259666952 1546 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2478 5763493 32.33 µM 0.587404181840073 0.272440305035872 no 922 0.278466142959617 1336 1365576 YLR208W SEC13 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.587376068073765 0.272449954637344 no 923 0.278475581555689 1355 688798 SGTC_319 1348-1596 45.5 µM 0.585378305499881 0.273136089003169 no 924 0.279146686399828 1445 5380505 SGTC_1687 st020778 55.3625 µM 0.584800483589234 0.273334702283353 no 925 0.279340939581032 1364 4259299 SGTC_1088 bifonazole 369 nM 0.583819575875117 0.273672030926594 no 926 0.279670853152935 1306 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2388 9080168 200 µM 0.583024471631755 0.273945613849806 no 927 0.279938413209137 1309 15943073 SGTC_3171 9103192 49.47 µM 0.581057901218418 0.274622860082673 no 928 0.280600715302712 1409 13018434 SGTC_1794 st048918 76.9 µM 0.57921145320877 0.275259489433323 no 929 0.281223251844592 1326 672303 SGTC_1711 st032263 62.8 µM 0.579017752235359 0.275326316888421 no 930 0.281288597450599 1381 3958979 SGTC_542 3381-0244 89.3 µM 0.578732818612989 0.275424634408304 no 931 0.281384733985124 1443 1112843 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.577438246874436 0.275871549116963 no 932 0.281821721748963 1415 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_107 0358-0022 2.6945 µM 0.575906734293836 0.276400720661428 no 933 0.282339111759057 1425 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_829 1635-0120 117 µM 0.575567003491567 0.27651817261453 no 934 0.282453944717651 1429 285054 SGTC_2810 7959871 45.46 µM 0.574742694948251 0.276803254771759 no 935 0.282732663912009 1419 2974535 SGTC_2408 sulbentine 18.36 µM 0.574612422688976 0.276848321820473 no 936 0.282776724288248 1464 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1037 k284-1091 78.7 µM 0.574136562096882 0.277012973988503 no 937 0.282937696760297 1346 3334711 SGTC_500 h-89 112 µM 0.573207887280114 0.277334442058376 no 938 0.283251972318123 1482 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_226 1,3-diallylurea 8.28947 mM 0.573118511407424 0.277365389837992 no 939 0.283282227098633 1350 74537 YKL182W FAS1 SGTC_1525 8-methoxypsoralen 92.5 µM 0.572916031590089 0.277435507854815 no 940 0.283350774622447 1459 4114 Related to psoralen; DNA damaging agent. SGTC_2226 7298446 200 µM 0.572881735497261 0.277447385323846 no 941 0.283362386010409 1381 3283010 SGTC_111 0083-0039 52.457 µM 0.571700512246803 0.277856619788876 no 942 0.283762443674083 1308 759313 SGTC_1177 0983-0204 23.6 µM 0.571128978400524 0.278054733256972 no 943 0.283956108266383 1400 766818 SGTC_3192 9110362 49.47 µM 0.569443098575942 0.278639518851087 no 944 0.284527737827774 1457 16649480 SGTC_313 3474-0040 5.03 µM 0.569227444847614 0.278714366411944 no 945 0.284600898949171 1334 1043375 YIL048W NEO1 SGTC_1715 st032160 10.2275 µM 0.568825222133542 0.278853993155263 no 946 0.284737378109099 1368 5289825 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.567768356358189 0.279221033442306 no 947 0.285096134580744 1409 368090 SGTC_2228 7354201 200 µM 0.567740670745096 0.279230651570026 no 948 0.285105535446326 1416 753451 SGTC_1159 4092-0538 61.2 µM 0.566803320916831 0.279556386813695 no 949 0.285423907043511 1426 717301 SGTC_349 k015-0014 24 µM 0.56655961202227 0.279641107469006 no 950 0.285506710680122 1371 2196908 SGTC_1410 3909-8106 77.9 µM 0.564265855877586 0.280439097177909 no 951 0.28628660742182 1422 1039210 SGTC_1289 0976-0073 69.1 µM 0.563811191522249 0.280597404126456 no 952 0.286441317236514 1427 3391136 SGTC_2898 9056270 58.44 µM 0.56329151626193 0.280778399784054 no 953 0.28661819705529 1343 19154699 SGTC_2969 9091408 28.7 µM 0.563116447430416 0.280839386531181 no 954 0.286677796205924 1354 4286311 SGTC_408 cantharidin 100 µM 0.562725669853863 0.280975540390191 no 955 0.286810850855583 1385 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2291 7917025 104.35 µM 0.559939156530403 0.281947334816228 no 956 0.287760469611598 1345 2964612 SGTC_2328 6201408 200 µM 0.55893475268227 0.282298016460565 no 957 0.288103125274054 1375 2890418 SGTC_375 3970-0961 9.27 µM 0.558161645979618 0.282568084940607 no 958 0.288367004225383 1412 2898222 SGTC_2693 st077581 40.7 µM 0.556550514679423 0.283131298395144 no 959 0.288917285950323 1408 25238761 SGTC_2240 6690706 185.951 µM 0.556432290530048 0.283172647970371 no 960 0.288957684848807 1320 805876 SGTC_3189 9110682 49.47 µM 0.554461117129944 0.283862503705065 no 961 0.289631654521187 1427 17122418 SGTC_960 1222-0186 7.7 µM 0.552608909135457 0.284511457072505 no 962 0.290265620048228 1463 3126296 SGTC_2612 dictamnine 15.46 µM 0.551504484664545 0.284898748388703 no 963 0.290643946620571 1418 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_506 n9-isopropylolomoucine 153 µM 0.549212534418366 0.285703273882528 no 964 0.291429801732682 1467 6610355 SGTC_1156 4092-0367 4.88 µM 0.548014697594371 0.286124170841863 no 965 0.291840905450544 1414 1357585 SGTC_2763 lisinopril 49.32 µM 0.547825233811926 0.286190771764314 no 966 0.291905955125358 1389 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_411 enrofloxacin 100 µM 0.543889959093314 0.287575774227733 no 967 0.293258599468907 1554 71188 A bacterial gyrase inhibitor. SGTC_2234 tolnaftate 200 µM 0.54189042623278 0.288280712838177 no 968 0.293946996210615 1411 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1250 0485-0349 40.2 µM 0.540571508942797 0.288746144914903 no 969 0.294401480060668 1431 6842794 YDL195W SEC31 SGTC_10 0279-0212 42.575 µM 0.540419568546448 0.288799785806793 no 970 0.294453857820319 1412 39851 YBR002C RER2 SGTC_677 0929-0063 136 µM 0.537380546945643 0.289873663044569 no 971 0.295502388864797 1402 1539583 SGTC_1149 3909-7961 23.3 µM 0.536704956239921 0.290112645895028 no 972 0.295735715985978 1380 735261 SGTC_3277 9138724 49.47 µM 0.536120367888888 0.290319512141243 no 973 0.295937682136307 1399 15943418 SGTC_882 0843-0131 351 µM 0.535657511839199 0.290483350385167 no 974 0.296097636585226 1434 5425421 SGTC_1968 st069590 43.6 µM 0.53436539166604 0.290940954080397 no 975 0.296544379137808 1440 6384066 SGTC_3295 9122362 53.5725 µM 0.533483122218016 0.291253602759953 no 976 0.296849595647774 1421 4730473 SGTC_1809 st050081 57.6 µM 0.532229201061174 0.291698222820612 no 977 0.29728363032019 1508 5036894 SGTC_792 4534-1957 155 µM 0.531800512301348 0.291850301417777 no 978 0.297432083958786 1448 1717904 SGTC_3344 9148862 3.898 µM 0.530995548334587 0.29213596449553 no 979 0.297710932014066 1504 4905352 SGTC_3132 9126706 49.47 µM 0.529504927622868 0.292665294570571 no 980 0.298227613518992 1451 850858 SGTC_1384 3089-0840 101 µM 0.529132496699546 0.292797616982952 no 981 0.29835676989573 1515 1069836 SGTC_1137 ixabepilone 100 µM 0.528828317107489 0.292905710721351 no 982 0.298462276085173 1413 154225 A novel microtubule stabilizer. SGTC_2017 5132927 60.65 µM 0.527173301218242 0.293494164037869 no 983 0.29903662371838 1398 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_139 0099-0334 718.624 µM 0.525098626162048 0.294232602756379 no 984 0.299757315552895 1462 97690 SGTC_2493 resveratrol 26.09 µM 0.523599318046765 0.294766784883303 no 985 0.300278627964694 1398 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_3036 9090181 49.47 µM 0.522680104009401 0.295094508709478 no 986 0.300598443014804 1481 25236586 SGTC_1326 1431-2094 10.8 µM 0.521897189125767 0.295373770582228 no 987 0.30087095775843 1423 616278 SGTC_3291 9121177 71.43 µM 0.521874165370027 0.295381984882334 no 988 0.300878973486961 1421 17015612 SGTC_1527 coumarin 137 µM 0.521660886115569 0.295458082580707 no 989 0.300953231311325 1500 323 A hepatotoxic, DNA x-linker. SGTC_2280 7785178 200 µM 0.521019508044441 0.29568697956789 no 990 0.301176590849372 1473 2954328 SGTC_618 k072-0232 33.2 µM 0.520670897678399 0.295811426888628 no 991 0.301298025525029 1460 5872756 YGL099W LSG1 SGTC_1102 cgs 12066b 26.1 µM 0.518588510645976 0.296555300356416 no 992 0.302023861418056 1455 6438352 A 5-HT1B full agonist. SGTC_2867 9039098 71.43 µM 0.51713668810389 0.297074429114414 no 993 0.302530372163386 1423 6463460 SGTC_443 clozapine 122 µM 0.515040456588715 0.297824711714206 no 994 0.303262374803209 1441 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2844 9010103 25.97 µM 0.514539231412246 0.298004238030003 no 995 0.303437519526345 1455 2480525 SGTC_2781 5567276 71.43 µM 0.514497815649658 0.298019074325615 no 996 0.303451993590349 1509 2853274 SGTC_2868 9035608 32.47 µM 0.511907671828101 0.298947605004955 no 997 0.304357814319258 1427 6462614 SGTC_75 0159-0059 199.013 µM 0.511212813782681 0.299196925350307 no 998 0.304601023545067 1562 5377270 SGTC_3143 9086658 49.47 µM 0.509671058957558 0.299750455356299 no 999 0.305140965936784 1497 25236626 SGTC_1859 st055998 20 µM 0.506954577415073 0.300726869439044 no 1000 0.306093344922278 1602 676301 SGTC_400 oxethazaine 37.5 µM 0.506899764142702 0.300746586326481 no 1001 0.306112575589379 1462 4621 A local anesthetic. SGTC_1830 st055982 50.3 µM 0.50650302726503 0.300889313973612 no 1002 0.306251782528132 1498 455313 An antimicrobial agent. SGTC_152 4469-0003 551.229 µM 0.504628908697823 0.301563948063815 no 1003 0.306909750736264 1489 697280 SGTC_2860 9025725 38.96 µM 0.504375010375246 0.301655397192898 no 1004 0.306998937642101 1421 40546248 SGTC_2904 7225135 42.03 µM 0.499557936227178 0.303392768850392 no 1005 0.308693191248998 1532 4446116 SGTC_2791 5663188 71.43 µM 0.49951465292335 0.303408400068267 no 1006 0.308708433331374 1556 54690634 SGTC_2636 apigenin dimethyl ether 100 µM 0.498698509628392 0.30370320723145 no 1007 0.308995897350728 1489 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_227 fluconazole 33.516 µM 0.498153723875744 0.303900065784936 no 1008 0.309187848280169 1441 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2589 lobaric acid 100 µM 0.49805982825299 0.303934000755063 no 1009 0.309220936921306 1455 73157 A novel microtubule depolymerizer. SGTC_880 0833-0487 87.2 µM 0.496633932167542 0.304449543705621 no 1010 0.309723610077678 1459 76075 SGTC_981 1488-1094 54.9 µM 0.495762832208516 0.304764687523029 no 1011 0.310030875443961 1445 3449522 SGTC_1900 st060200 72.8 µM 0.494867473330448 0.305088758694283 no 1012 0.310346836040176 1490 688945 SGTC_674 0498-0004 451 µM 0.492320499281327 0.306011460106582 no 1013 0.31124639539423 1443 4231473 SGTC_2191 5911152 200 µM 0.49140863380232 0.306342104769077 no 1014 0.311568729480516 1498 2875902 SGTC_2549 cedrol 20.94 µM 0.491183638945802 0.306423712732422 no 1015 0.311648284834859 1545 6708665 A sedative which affects the nervous system. SGTC_1199 1638-0010 4.46 µM 0.488316157502557 0.307464617813665 no 1016 0.312662959286308 1474 3111136 SGTC_2075 5212009 200 µM 0.488215037663925 0.307501353028934 no 1017 0.312698767100896 1533 780898 SGTC_1776 st049249 45.9 µM 0.487914365748953 0.307610593716874 no 1018 0.312805249273123 1457 1822314 SGTC_3338 9144300 39.5675 µM 0.486328329215087 0.308187117704443 no 1019 0.313367198341667 1538 4901274 SGTC_615 k087-0205 167 µM 0.485467123034428 0.308500364468514 no 1020 0.313672514274341 1446 9642773 SGTC_2645 abamectin 100 µM 0.48492497021169 0.308697633405273 no 1021 0.313864784494276 1534 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_458 nppb 133 µM 0.484714948836397 0.30877406709329 no 1022 0.31393928050536 1616 4549 A chloride channel blocker. SGTC_3243 9134147 49.47 µM 0.484474693604094 0.308861514034875 no 1023 0.314024509971501 1550 24282180 SGTC_2673 kobusone 100 µM 0.484301150438569 0.308924686180927 no 1024 0.314086079802708 1554 6710676 An epoxy ketone and protein crosslinker. SGTC_225 nsc-122657 1.016 µM 0.484072251488699 0.309008017253148 no 1025 0.314167296732763 1508 275685 SGTC_20 0481-0013 4.944 µM 0.480975993533317 0.310136179872564 no 1026 0.31526678039004 1477 182045 SGTC_3126 9127922 49.47 µM 0.479916902565868 0.310522484986054 no 1027 0.31564324094627 1527 45595682 SGTC_2960 9079389 5.97 µM 0.479623685011586 0.310629473525295 no 1028 0.315747500816662 1622 16457355 SGTC_1213 1315-0166 115 µM 0.478859049936869 0.310908547125543 no 1029 0.316019452386228 1451 768401 SGTC_2001 4023502 57.655 µM 0.478803284536497 0.310928904427518 no 1030 0.316039289913 1567 108941 YCR052W RSC6 SGTC_2343 7990716 14.84 µM 0.477509829705654 0.311401245674959 no 1031 0.316499561465752 1548 6456862 SGTC_2839 9003951 25.97 µM 0.476233074325131 0.311867793324 no 1032 0.316954169463046 1534 2990634 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.474371928399907 0.312548427942403 no 1033 0.317617353667921 1519 442882 SGTC_1470 k295-0292 231 µM 0.47326739688622 0.312952665887107 no 1034 0.318011209701517 1579 5045612 SGTC_2439 5492030 7.2 µM 0.472483414668264 0.313239725317453 no 1035 0.318290888615987 1560 5722370 SGTC_282 k297-0036 65.7 µM 0.472408209532439 0.313267268047561 no 1036 0.318317722850193 1537 5061378 SGTC_541 4513-1321 94 µM 0.471237453135554 0.313696173909756 no 1037 0.318735587820287 1477 747515 SGTC_2597 laccaic acid a 100 µM 0.470801981131793 0.313855773116283 no 1038 0.318891074828962 1538 5491415 A textile dye. SGTC_1556 plumbagin 1.48 µM 0.469885972902051 0.314191601106847 no 1039 0.319218243241143 1493 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2772 vinpocetine 57.06 µM 0.468576737524895 0.314671861610884 no 1040 0.319686104100651 1576 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1015 4130-4525 82 µM 0.468285060218534 0.31477889894704 no 1041 0.319790375362085 1482 1363237 SGTC_1353 1498-1206 8.11 µM 0.468016734481859 0.314877380660968 no 1042 0.319886311286146 1520 6756808 SGTC_2253 7938677 135.83 µM 0.467460077341232 0.315081728608789 no 1043 0.320085374285139 1642 2301972 SGTC_1296 1068-0102 11.9 µM 0.467034284157938 0.315238074820742 no 1044 0.320237674739022 1576 767053 SGTC_2733 amorolfine 100 µM 0.466884157090131 0.31529320759468 no 1045 0.320291380381143 1593 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1487 3970-0795 2.82 µM 0.466130589048259 0.31557001059769 no 1046 0.320561014573919 1567 3765103 SGTC_927 2425-1185 123 µM 0.465822370503855 0.315683256246213 no 1047 0.320671325559098 1472 730375 SGTC_1216 1165-0504 9.65 µM 0.464184247661748 0.316285425529115 no 1048 0.321257873025948 1603 6304004 SGTC_2297 7971671 152.32 µM 0.463236564601596 0.316634013832649 no 1049 0.321597404920642 1627 909016 SGTC_3203 9113543 49.47 µM 0.461384608939802 0.317315692732508 no 1050 0.322261345920118 1588 17018012 SGTC_2275 7947463 200 µM 0.459567375442684 0.317985193831805 no 1051 0.322913390449222 1522 1225414 SGTC_719 2810-4230 27.3 µM 0.459371662759131 0.31805733340769 no 1052 0.322983646963198 1561 721079 SGTC_1658 st012944 20 µM 0.458771015798899 0.318278774607308 no 1053 0.32319930533617 1570 24207260 SGTC_2364 9055074 200 µM 0.458392482691203 0.318418362212086 no 1054 0.323335245714034 1485 6470630 SGTC_1795 st049545 62.3 µM 0.457408151980948 0.318781463969348 no 1055 0.323688853027287 1624 5291882 SGTC_3133 9127736 49.47 µM 0.457124154183786 0.318886257974243 no 1056 0.323790904954944 1631 27243420 SGTC_2389 9091542 195.52 µM 0.455723286621599 0.319403384028078 no 1057 0.324294487230839 1527 3626624 YOL127W RPL25 SGTC_713 1488-1073 324 µM 0.453983677399625 0.320046044728719 no 1058 0.324920287526479 1563 3312542 SGTC_1064 honokiol 6.76 µM 0.453819778464414 0.320106621499427 no 1059 0.324979273404857 1546 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_551 k048-0028 34.9 µM 0.452257696871248 0.320684204704237 no 1060 0.325541673720903 1634 6836383 SGTC_2565 isoliquiritigenin 100 µM 0.451929256647605 0.320805701536871 no 1061 0.325659973518627 1465 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1928 4'-methoxychalcone 40.3 µM 0.451226688469413 0.321065660472916 no 1062 0.325913088172915 1720 641818 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.450913157193782 0.32118169924863 no 1063 0.326026070176279 1455 641818 YHR062C RPP1 SGTC_3176 9106582 49.47 µM 0.449765120529495 0.321606739687259 no 1064 0.326439905144523 1527 17018027 SGTC_1760 st045453 10.4495 µM 0.449437703383522 0.321728002983098 no 1065 0.326557969018404 1607 3323419 YIL048W NEO1 SGTC_2954 9074818 52.69 µM 0.448800368288072 0.321964102974062 no 1066 0.326787836521372 1598 16648742 SGTC_1055 3448-0672 86 µM 0.44780315486302 0.32233366364714 no 1067 0.327147633172284 1564 748378 SGTC_2848 9016370 25.97 µM 0.447683555308588 0.322377998252456 no 1068 0.327190795735457 1657 7894410 SGTC_2469 5655019 90.81 µM 0.446139203880855 0.322950703817704 no 1069 0.327748347756341 1676 2788239 SGTC_657 3534-0529 86.7 µM 0.445984548601357 0.323008079170518 no 1070 0.327804203619708 1650 1049549 SGTC_712 r015-0009 80.6 µM 0.445577459870622 0.323159124599642 no 1071 0.327951247681612 1625 6813872 YLR060W FRS1 SGTC_1346 1488-2224 62.4 µM 0.445325523601932 0.32325261716374 no 1072 0.328042262661073 1614 3722427 SGTC_2752 diclazuril 33.15 µM 0.444657333773331 0.323500633853328 no 1073 0.328283703645854 1604 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.443354660433129 0.323984381659909 no 1074 0.32875461251652 1568 1241132 A phosphatase inhibitor. SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.44298275609317 0.324122542963023 no 1075 0.328889103731493 1618 676296 Flavone; oxidizing agent. SGTC_910 3454-3003 490 µM 0.442873956734403 0.324162966166771 no 1076 0.328928452872406 1572 820824 SGTC_1498 4478-3555 97.6 µM 0.441508016972377 0.32467064229555 no 1077 0.329422629456457 1603 3437919 SGTC_168 3970-0862 530.542 µM 0.4415055769872 0.324671549451886 no 1078 0.329423512473573 1574 3135186 SGTC_2995 9067767 71.4286 µM 0.440560416720435 0.325023026544424 no 1079 0.329765632247609 1587 11673567 SGTC_1405 3909-7894 12 µM 0.440208089027334 0.325154086647431 no 1080 0.329893200815367 1655 7104060 SGTC_3083 9117465 49.47 µM 0.440011984699847 0.325227043602566 no 1081 0.329964213594167 1519 16420915 SGTC_1829 berberine 14.4 µM 0.439872225904394 0.32527904234317 no 1082 0.330014826418285 1669 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2491 paeonol 100 µM 0.438143159073329 0.325922641117089 no 1083 0.330641254909156 1541 11092 Increases levels of cortical cytochrome oxidase. SGTC_709 3807-1509 243 µM 0.43724184148163 0.326258338352537 no 1084 0.330967984131143 1599 1886677 YPL242C IQG1 SGTC_3068 9116768 49.47 µM 0.436611369383508 0.326493242450958 no 1085 0.331196607946473 1544 41904888 SGTC_2777 climbazole 1.536 µM 0.435566710219818 0.326882617665825 no 1086 0.331575564118272 1608 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_52 0329-0193 875 nM 0.435549039114357 0.326889205829977 no 1087 0.331581975898644 1650 3739292 SGTC_987 1497-1013 404 µM 0.435325280491471 0.326972632473181 no 1088 0.331663168700771 1611 1676435 SGTC_84 0443-0269 128.823 µM 0.435134349855797 0.327043826297921 no 1089 0.331732455830284 1539 6150058 SGTC_680 0417-1641 114 µM 0.435037368339918 0.327079990977973 no 1090 0.331767651815386 1550 2835990 SGTC_2967 9089538 49.85 µM 0.433415176709033 0.327685151310555 no 1091 0.332356588406355 1751 728216 SGTC_2200 6600604 21.907 µM 0.432020481245416 0.328205806126836 no 1092 0.33286326372735 1540 2904777 SGTC_191 3914-0123 66.505 µM 0.43174397837772 0.3283090673147 no 1093 0.332963750040063 1517 3144412 SGTC_2304 7443016 91.4 µM 0.430686453544334 0.328704125502031 no 1094 0.333348184969879 1561 939854 SGTC_1475 4092-1048 11.7 µM 0.429435513403813 0.329171684835037 no 1095 0.333803156956376 1562 2881759 SGTC_1133 3473-0247 50 µM 0.428836206833578 0.329395780230237 no 1096 0.334021213833272 1509 711311 SGTC_426 0988-0037 14.6 µM 0.428770839923875 0.329420226226314 no 1097 0.334045000885257 1634 5383008 SGTC_610 4215-0184 155 µM 0.428758919195345 0.32942468443342 no 1098 0.334049338916367 1609 5605015 SGTC_1416 3966-0321 25.3 µM 0.428565189453582 0.329497140393158 no 1099 0.334119841544756 1596 582530 YLR208W SEC13 SGTC_2013 4024628 200 µM 0.428250690492644 0.329614778317792 no 1100 0.334234307283605 1619 5230760 SGTC_2369 9071472 200 µM 0.426860935341244 0.330134816156435 no 1101 0.334740310120098 1635 17296037 SGTC_2073 5212005 126 µM 0.425123045543003 0.330785585820527 no 1102 0.335373489442915 1588 691789 SGTC_186 3455-3465 67.277 µM 0.424839018969563 0.330891991025563 no 1103 0.335477015653953 1577 755278 SGTC_2337 9009472 200 µM 0.424582337649943 0.330988163600035 no 1104 0.335570585408716 1686 5742383 SGTC_1294 1000-1494 117 µM 0.424448670634228 0.33103824996684 no 1105 0.335619315976554 1545 712797 YDL207W GLE1 SGTC_1659 st012954 42.1 µM 0.424401616892507 0.3310558821938 no 1106 0.335636470870681 1612 24207262 SGTC_1058 3448-5425 97.3 µM 0.424124905691057 0.331159580458151 no 1107 0.335737361411512 1557 7279705 SGTC_2211 7117706 200 µM 0.423976532413611 0.331215189075866 no 1108 0.33579146406342 1652 822771 SGTC_1391 3442-0225 151 µM 0.422938837326872 0.331604209395756 no 1109 0.336169943027541 1604 5227075 SGTC_857 0438-0306 1.35 µM 0.422340064888089 0.331828765210201 no 1110 0.336388409165122 1600 4686136 SGTC_2093 5331342 194.4 µM 0.422163986548073 0.33189481083867 no 1111 0.336452663043695 1668 33839 SGTC_40 0327-0103 19.753 µM 0.421551443412842 0.332124611735921 no 1112 0.336676227295512 1537 409036 SGTC_105 0111-0055 734.78 µM 0.421465800687421 0.332156746384521 no 1113 0.336707489535988 1594 5179370 SGTC_317 4495-0002 170 µM 0.420893560316064 0.3323714926465 no 1114 0.336916403900054 1574 15991618 SGTC_1191 1487-1166 10.6 µM 0.41972100533946 0.332811692545815 no 1115 0.337344639153095 1674 3955771 SGTC_2114 5491910 81.25 µM 0.418641701928267 0.333217087811355 no 1116 0.33773900382544 1677 2849228 SGTC_2091 4-phenylthiadiazole 200 µM 0.418110638740944 0.333416631113085 no 1117 0.337933113466234 1616 270010 SGTC_2653 dihydrofissinolide 100 µM 0.416462843295839 0.334036078698566 no 1118 0.338535675632698 1641 6857746 SGTC_2222 6885208 172.143 µM 0.416165184214822 0.334148024496105 no 1119 0.338644567091239 1607 609514 SGTC_3073 9114972 49.47 µM 0.41615521822648 0.33415177283301 no 1120 0.338648213143247 1712 41905075 SGTC_2975 9084847 53.72 µM 0.415190280053038 0.334514776825853 no 1121 0.339001306873974 1583 27211724 SGTC_3037 9091026 49.47 µM 0.415172666451927 0.334521404396934 no 1122 0.339007753423516 1617 25236398 YIL048W NEO1 SGTC_2159 5658611 73.75 µM 0.415044405847262 0.334569667307834 no 1123 0.339054698018956 1675 793844 SGTC_311 1315-0136 58 µM 0.415005595173966 0.334584271832565 no 1124 0.339068903585315 1681 6759207 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.414445710523668 0.334794985252387 no 1125 0.339273859222823 1585 15053 SGTC_3252 9135871 49.47 µM 0.412832540340941 0.335402394967187 no 1126 0.339864654344451 1644 17682838 SGTC_3130 9127414 49.47 µM 0.41271153436107 0.335447974931367 no 1127 0.339908986534625 1598 1494646 SGTC_870 0573-2213 57.6 µM 0.412022328216576 0.335707628030091 no 1128 0.340161528801274 1562 3916321 SGTC_1984 st072354 53.1 µM 0.411987081465376 0.335720909081578 no 1129 0.340174446015899 1630 5762938 SGTC_985 1493-0307 8.71 µM 0.411419390717901 0.335934844430837 no 1130 0.340382518914037 1729 3278274 SGTC_2852 9023854 51.95 µM 0.410664610982937 0.336219366955228 no 1131 0.340659239878165 1674 19798528 SGTC_970 1315-0089 19.5 µM 0.40550231612513 0.338167859308852 no 1132 0.3425541581423 1539 6811083 YLR033W RSC58 SGTC_3340 9146634 11.102 µM 0.402712893090365 0.339222529337939 no 1133 0.343579723977234 1602 4907387 SGTC_255 tunicamycin 200.472 nM 0.40184249352573 0.339551882544878 no 1134 0.343899973402131 1733 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_796 1234-0020 70.7 µM 0.399578978322571 0.340408954440231 no 1135 0.344733321153903 1565 46495034 SGTC_2244 6635614 200 µM 0.398949577985057 0.340647421391051 no 1136 0.344965178661572 1614 836499 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.39838058921941 0.340863054462964 no 1137 0.345174831963018 1602 88881 An O-methylated flavonoid and antioxidant. SGTC_378 3970-0959 8.33 µM 0.397694208222901 0.341123245570629 no 1138 0.345427803612974 1662 6615653 SGTC_2719 novobiocin 32.65 µM 0.396224175174189 0.341680755085577 no 1139 0.345969829223731 1725 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_605 1315-0399 119 µM 0.395093325505066 0.342109864639957 no 1140 0.346387007247924 1692 24020461 SGTC_3215 9129942 49.47 µM 0.394840036895158 0.342206004920862 no 1141 0.346480472685289 1750 17682944 SGTC_716 1683-5115 658 µM 0.394429237017869 0.342361953202758 no 1142 0.346632080859576 1671 723597 SGTC_1847 st056231 15 µM 0.393247631825155 0.342810665197417 no 1143 0.347068296272328 1593 5393180 SGTC_266 formosanin C 406 nM 0.393125021046194 0.342857239087782 no 1144 0.347113572343468 1650 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_58 0957-0393 9 µM 0.392344466132434 0.343153790024706 no 1145 0.347401856385324 1610 6997992 SGTC_1424 4048-1941 275 µM 0.391948385769447 0.34330430711769 no 1146 0.347548175386692 1753 X1424 SGTC_1720 st037298 9.481 µM 0.391561191909675 0.343451471221153 no 1147 0.347691233516736 1618 597396 SGTC_2404 5161160 200 µM 0.390619077703381 0.343809647779742 no 1148 0.348039410942512 1688 2831543 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.388180896116743 0.344737255347001 no 1149 0.348941084793879 1624 2724 A muscle relaxant with antifungal properties. SGTC_918 glabranin 770.725 nM 0.387550948409679 0.344977071399269 no 1150 0.349174187295326 1686 124049 Also referred to as licorice root. SGTC_308 4092-1169 104 µM 0.387429773840826 0.345023208733834 no 1151 0.349219032618229 1650 2268590 YDL196W YDL196W SGTC_2186 6124449 200 µM 0.385708795766188 0.345678721254681 no 1152 0.349856173956507 1693 3834182 YLR033W RSC58 SGTC_2889 9059656 51.95 µM 0.383840612561005 0.34639082757675 no 1153 0.350548292499591 1700 3949838 SGTC_1324 1418-0026 34.4 µM 0.383579515858684 0.346490394662694 no 1154 0.350645062361642 1685 1372513 SGTC_1666 st014829 29 µM 0.383055137638202 0.346690394034354 no 1155 0.350839441114352 1627 3858230 SGTC_2618 avocadyne 43.43 µM 0.382826081124362 0.346777770265854 no 1156 0.350924361015113 1727 3015189 SGTC_922 1866-0035 480 µM 0.380738003346777 0.3475746667341 no 1157 0.351698833200198 1687 3156169 SGTC_203 k066-0004 30.888 µM 0.38069740433465 0.34759016768047 no 1158 0.351713897568138 1739 6795412 SGTC_2991 9074669 71.4286 µM 0.379589480689967 0.348013277861801 no 1159 0.352125085290978 1731 17333109 SGTC_3124 9127567 49.47 µM 0.379475165124988 0.348056945153657 no 1160 0.352167521492708 1767 17592030 SGTC_2774 tamoxifen 10.92 µM 0.379299834466039 0.34812392345695 no 1161 0.352232611282561 1663 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2185 6113692 200 µM 0.379195933789152 0.348163616931572 no 1162 0.352271185434006 1666 874150 SGTC_741 4582-0002 126 µM 0.377755073431987 0.348714244271104 no 1163 0.352806275576676 1620 2912688 SGTC_596 1155-0152 116 µM 0.377741932557512 0.348719267548444 no 1164 0.352811157025483 1642 280313 SGTC_2163 5671233 125 µM 0.377507385402013 0.348808930837409 no 1165 0.352898288478325 1761 701023 SGTC_1007 4101-0031 70 µM 0.376181079597965 0.349316113183366 no 1166 0.353391140210017 1771 1146276 SGTC_2427 5545055 42.75 µM 0.376013321259001 0.349380283548612 no 1167 0.353453496303585 1697 5372858 SGTC_896 0964-0007 44.5 µM 0.373196706527088 0.350458327391936 no 1168 0.354501023607816 1758 6756758 SGTC_2835 9006588 71.43 µM 0.372798063871995 0.350611003276481 no 1169 0.354649371976569 1631 2345538 SGTC_646 4092-0839 27.3 µM 0.371484088989098 0.351114412393648 no 1170 0.355138502316754 1748 877796 SGTC_642 0335-0876 158 µM 0.370551703049395 0.351471786032162 no 1171 0.355485730142669 1681 6812350 SGTC_2323 6148992 148.28 µM 0.370253585920063 0.35158607888911 no 1172 0.355596776624047 1631 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_3146 9095609 49.47 µM 0.368997031591153 0.352067967046551 no 1173 0.356064968671662 1732 17173999 SGTC_2020 4017018 200 µM 0.368983942592497 0.352072987925111 no 1174 0.356069846775357 1659 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1445 4239-0156 97.7 µM 0.366627147140653 0.352977463234982 no 1175 0.356948577864887 1802 4008346 SGTC_2292 7671323 168.05 µM 0.366537472833774 0.353011894295531 no 1176 0.356982027954502 1651 937504 SGTC_2721 ifenprodil 61.44 µM 0.365611192277973 0.35336761639897 no 1177 0.357327611143272 1760 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_3024 9090631 49.47 µM 0.363416144011069 0.354211098010216 no 1178 0.358147021906335 1814 25236383 SGTC_113 0099-0221 2.5 µM 0.363388857484004 0.354221587797211 no 1179 0.358157212079536 1781 89219 SGTC_1955 wogonin 32.4 µM 0.362747771669919 0.354468072873068 no 1180 0.358396655099168 1786 5281703 A flavanone. SGTC_1147 3809-1045 12.3 µM 0.361057995308721 0.355118051024298 no 1181 0.359028046516765 1657 325925 SGTC_2595 hexamethylquercetagetin 100 µM 0.360863869303333 0.355192749291253 no 1182 0.359100607149696 1687 386331 SGTC_809 3998-0021 90 µM 0.360638401735092 0.355279514547257 no 1183 0.359184889047044 1801 715485 SGTC_1392 3455-1037 33.9 µM 0.358973734928657 0.355920349651583 no 1184 0.359807369003284 1758 981132 SGTC_248 streptozotocin 5.23457 mM 0.356992690520318 0.356683509120659 no 1185 0.360548638904038 1787 5300 DNA alkylating agent. SGTC_1625 st003711 30.1 µM 0.356773024952968 0.356768166490387 no 1186 0.360630866011264 1758 24207034 YER133W GLC7 SGTC_3045 9092950 49.47 µM 0.356450227138417 0.356892583011845 no 1187 0.360751710161786 1817 44120432 SGTC_3096 9117468 49.47 µM 0.356065237575978 0.357040990111081 no 1188 0.360895854896768 1734 41316311 SGTC_1314 1222-0010 41.1 µM 0.355056947479633 0.35742977171652 no 1189 0.361273464469608 1706 3526027 SGTC_2598 perillyl alcohol 100 µM 0.354785186464701 0.357534584046663 no 1190 0.36137526344516 1757 10819 An apoptosis inducer. SGTC_2363 9053361 176 µM 0.354745246530821 0.357549988918939 no 1191 0.361390225374934 1805 6469797 YMR079W SEC14 SGTC_1974 st069448 26.9 µM 0.35463964951618 0.35759071891058 no 1192 0.361429784176036 1810 6323587 YNR016C ACC1 SGTC_3355 9151058 44.0485 µM 0.353463048702001 0.358044657095768 no 1193 0.36187066303075 1703 17015728 SGTC_2202 7226349 200 µM 0.351689401839997 0.358729317757606 no 1194 0.36253560477529 1682 844334 SGTC_564 3555-0129 330 µM 0.35140974455614 0.358837312178024 no 1195 0.362640486447147 1764 563260 SGTC_3081 9117243 49.47 µM 0.350697466241533 0.359112421531348 no 1196 0.362907663312904 1817 45595589 SGTC_2892 9047358 58.44 µM 0.349532898230601 0.359562379967632 no 1197 0.363344638576288 1693 6466771 SGTC_279 1273-0055 2.93 µM 0.34911331392853 0.35972454406405 no 1198 0.363502120803422 1835 2847562 SGTC_904 1141-0088 396 µM 0.346786671580843 0.360624219929906 no 1199 0.364375795516523 1634 1378119 SGTC_3002 9075603 71.4286 µM 0.346772483365599 0.360629708662015 no 1200 0.364381125484002 1709 20105405 SGTC_431 k089-0097 107 µM 0.344460263481944 0.361524577230452 no 1201 0.365250087368101 1702 5499420 SGTC_197 4544-0043 41.561 µM 0.343000601105181 0.362089882116125 no 1202 0.365799003970974 1709 896523 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.342531491571898 0.36227162501908 no 1203 0.365975474425351 1764 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2568 diosmetin 100 µM 0.341848055991011 0.362536457903115 no 1204 0.36623262117489 1808 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1039 k821-0043 94 µM 0.34164044150435 0.362616922035362 no 1205 0.36631074927822 1806 15992768 SGTC_340 k038-0059 454 µM 0.341307095729598 0.36274612792011 no 1206 0.366436203334892 1756 23733424 SGTC_684 1140-0066 328 µM 0.340287083192717 0.363141585056109 no 1207 0.366820171750295 1703 6813534 SGTC_2854 9024559 71.43 µM 0.34022811193278 0.36316445258067 no 1208 0.366842374675714 1657 3163529 SGTC_1834 st055981 52.8 µM 0.340086663119506 0.363219304748518 no 1209 0.36689563255971 1823 471719 YDL150W RPC53 SGTC_1998 st075797 76.8 µM 0.338455750128715 0.363851955798282 no 1210 0.36750988387147 1833 24208315 SGTC_3039 9090270 49.47 µM 0.336924924575034 0.364446119620431 no 1211 0.36808674781836 1862 17173750 SGTC_217 ketoconazole 989 nM 0.335868164503976 0.364856473219336 no 1212 0.368485142460653 1739 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_306 1672-3436 11.6 µM 0.335663183996039 0.364936087747123 no 1213 0.368562435744118 1780 6797378 SGTC_53 0973-0023 39.979 µM 0.334820188070032 0.365263568957837 no 1214 0.368880365374996 1912 674768 SGTC_3057 9095946 49.47 µM 0.332183656411915 0.366288423822577 no 1215 0.36987529201901 1743 24540043 SGTC_1497 4476-2978 41.3 µM 0.331624562816793 0.366505873830619 no 1216 0.37008638488894 1750 1528379 SGTC_110 0850-0284 111.64 µM 0.331517382965351 0.366547564521001 no 1217 0.37012685647258 1727 3906265 SGTC_133 0724-0033 378.92 µM 0.331458471237816 0.366570480604976 no 1218 0.370149102412665 1735 280309 SGTC_2879 9041815 71.43 µM 0.32771430106097 0.368027898675712 no 1219 0.371563844669648 1750 4942971 SGTC_433 pimozide 108 µM 0.327370014515215 0.368162007984938 no 1220 0.371694021508155 1607 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1982 st072467 71.9 µM 0.326673246735584 0.368433467813639 no 1221 0.371957518528326 1703 3163533 SGTC_305 1682-2595 20.8 µM 0.326337345014939 0.368564358164479 no 1222 0.372084568085914 1775 226033 SGTC_2496 diffractaic acid 79.83 µM 0.326006305269911 0.368693368878342 no 1223 0.372209792304199 1862 94870 An apoptosis inducer which activates caspases. SGTC_1550 gossypolone 36.6 µM 0.325601166146712 0.368851277271376 no 1224 0.372363064890462 1752 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1957 st077035 62.4 µM 0.324177254214261 0.36940644150212 no 1225 0.372901920762673 1771 705593 SGTC_1514 1189-1591 158 µM 0.321615487615179 0.370405925353717 no 1226 0.373872004665904 1817 767698 YMR146C TIF34 SGTC_3237 9133362 49.47 µM 0.321494436268764 0.370453175752625 no 1227 0.373917863941238 1794 43845137 SGTC_1323 1348-1351 11.2 µM 0.321368790490822 0.37050222157935 no 1228 0.373965465665608 1724 6989654 SGTC_3241 9133421 49.47 µM 0.319515869769607 0.371225753161121 no 1229 0.374667679620271 1766 17018221 SGTC_1553 gossypol 38.6 µM 0.318708792617508 0.37154104451945 no 1230 0.374973673276284 1754 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3086 9117350 49.47 µM 0.318563376703148 0.371597861619048 no 1231 0.375028814356738 1726 2679265 SGTC_264 promethazine 12.5 mM 0.318216234725546 0.371733508702463 no 1232 0.375160459406235 1850 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1157 4092-0394 27.6 µM 0.315038701002257 0.372975880533017 no 1233 0.376366134855548 1835 3659885 SGTC_3213 9129884 49.47 µM 0.314964515676416 0.373004901815742 no 1234 0.376394298017934 1643 17190742 SGTC_2918 7977171 22.06 µM 0.314263491097691 0.373279178032655 no 1235 0.376660462217936 1749 2236483 SGTC_3288 9119690 36.221 µM 0.313793479698435 0.373463106200172 no 1236 0.376838948449085 1698 17595618 YKL019W RAM2 SGTC_3120 9124077 49.47 µM 0.311959831023032 0.374180937783529 no 1237 0.377535525569129 1788 18774327 YGL155W CDC43 SGTC_1165 k072-0275 30.3 µM 0.311005117675178 0.374554859202628 no 1238 0.377898365546252 1820 6153523 YGL055W OLE1 SGTC_1161 k007-0610 110 µM 0.310924012271008 0.374586630251144 no 1239 0.377929194724307 1816 5843850 SGTC_339 3091-4833 71.4 µM 0.310204473260392 0.37486852923225 no 1240 0.378202734520063 1799 3240077 SGTC_477 mead ethanolamide 10 µM 0.308053840549679 0.375711496188227 no 1241 0.379020682087901 1765 16061185 SGTC_3142 9086498 49.47 µM 0.306448505617953 0.376341114135575 no 1242 0.37963159072744 1917 25236367 SGTC_2678 equilin 100 µM 0.30629207263493 0.376402485324714 no 1243 0.379691137243141 1878 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2162 5663267 200 µM 0.305995897535627 0.376518688163322 no 1244 0.379803884677705 1851 6456493 SGTC_2375 9072683 200 µM 0.305572079136831 0.376684990683059 no 1245 0.37996524091828 1932 16798029 SGTC_1050 3232-1156 69.3 µM 0.305384431630527 0.376758629184889 no 1246 0.380036688797336 1732 700529 SGTC_3111 9122088 49.47 µM 0.305228120674097 0.376819973709437 no 1247 0.380096208228798 1871 16876704 SGTC_568 1193-0097 7.48 µM 0.304758936313056 0.377004124653423 no 1248 0.380274879334488 1818 3646150 SGTC_108 0509-0257 621.132 µM 0.303479146266659 0.377506573702734 no 1249 0.380762368724651 1851 536624 SGTC_665 3914-0008 307 µM 0.303377430641163 0.377546516440901 no 1250 0.380801121719435 1720 1069549 SGTC_1923 st058458 19.1 µM 0.302991059720823 0.377698252481214 no 1251 0.380948337434341 1896 3534982 SGTC_207 4185-0010 4.486 µM 0.302987696484605 0.377699573378179 no 1252 0.380949618976105 1878 3761753 SGTC_1255 0566-0045 221 µM 0.302895415551026 0.377735816887028 no 1253 0.380984782603065 1828 2788469 SGTC_363 0455-0021 3.06 µM 0.30286419814519 0.377748077825097 no 1254 0.380996678210355 1753 4597466 SGTC_2766 oltipraz 83.91 µM 0.302254528788435 0.377987556040049 no 1255 0.381229019447461 1857 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_806 3966-4455 5.86 µM 0.301500720195888 0.378283716994035 no 1256 0.381516350451375 1715 714982 SGTC_102 gallobenzophenone 83.616 µM 0.30117774722188 0.378410630499182 no 1257 0.381639478818198 1868 70837 SGTC_1221 2958-7315 257 µM 0.300921607704529 0.378511290861095 no 1258 0.381737136497551 1809 4562705 SGTC_755 1995-0008 37.3 µM 0.300205246883841 0.378792857509906 no 1259 0.382010301560857 1813 689533 SGTC_15 0266-0086 27.098 µM 0.29790687167773 0.379696670884693 no 1260 0.382887121558294 1882 1712902 YIL048W NEO1 SGTC_1065 prochlorperazine maleate 2.48 µM 0.29699729349735 0.38005453544159 no 1261 0.383234287720397 1783 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1861 st057647 17.4 µM 0.296975491970614 0.380063114298842 no 1262 0.383242610039956 1911 688668 SGTC_1898 st060199 18.6 µM 0.296114152605473 0.380402096800919 no 1263 0.383571453095416 1755 688866 SGTC_1596 piperlongumine 63 µM 0.294387404678197 0.381081939694332 no 1264 0.384230945166753 1912 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3317 9138495 8.753 µM 0.291599555526379 0.382180326052342 no 1265 0.385296407655111 1801 17020139 SGTC_3197 9113331 49.47 µM 0.291462009436145 0.382234542552402 no 1266 0.385348997625795 1900 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_490 phenamil 164 µM 0.291204637645759 0.382335996913627 no 1267 0.385447407938872 1878 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2809 7964133 12.99 µM 0.290663937589242 0.382549163821705 no 1268 0.385654177465843 1807 1253665 SGTC_1865 st057639 52.2 µM 0.290595619160319 0.382576100379585 no 1269 0.385680305482818 1825 688818 SGTC_2748 diazoxide 86.69 µM 0.290292441298787 0.382695644056376 no 1270 0.385796260488173 1855 3019 A potassium channel activatior. SGTC_2669 eugenol 100 µM 0.290177657928779 0.38274090630122 no 1271 0.385840163805691 1904 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_3009 9080819 71.4286 µM 0.289249788190676 0.383106849649435 no 1272 0.386195116941083 1767 17027216 SGTC_660 4031-1742 102 µM 0.287033204640198 0.383981471757961 no 1273 0.38704344792117 1791 6738706 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.286805127431191 0.384071500350192 no 1274 0.387130768343524 1901 23847180 SGTC_1447 4239-0816 81.9 µM 0.286352143571366 0.384250324571085 no 1275 0.387304212259645 1727 1341554 SGTC_1104 tacrolimus 29.8 µM 0.285974301339355 0.38439950401798 no 1276 0.387448902256245 1825 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2998 9066762 71.4286 µM 0.282828550825044 0.385642170139614 no 1277 0.388654133559256 1905 4945196 SGTC_345 1362-0200 395 µM 0.27984529583618 0.386821731253746 no 1278 0.389798099219987 1748 1419823 SGTC_537 1334-0398 209 µM 0.279510211274622 0.386954287233918 no 1279 0.389926651357585 1953 5846986 SGTC_145 3737-0113 38.366 µM 0.276818939897143 0.388019403332623 no 1280 0.390959568664757 1932 6849351 SGTC_78 0336-0123 156.75 µM 0.274463283863098 0.388952386168321 no 1281 0.391864307914403 1742 6765896 SGTC_754 3474-0146 171 µM 0.272890599193321 0.389575621837809 no 1282 0.39246865655808 1707 24762078 SGTC_534 k292-0788 63.4 µM 0.268821367056595 0.391189523552597 no 1283 0.394033574928462 1995 4146317 SGTC_759 3486-0358 89.3 µM 0.268595383966179 0.391279206123669 no 1284 0.3941205324329 1972 875103 SGTC_2449 5812982 45.77 µM 0.26854115269888 0.391300728945878 no 1285 0.394141401220759 1841 776185 SGTC_984 1492-0255 2.91 µM 0.267407034783699 0.391750903725663 no 1286 0.394577891812031 1853 1585198 SGTC_1204 4049-0315 18.3 µM 0.266956411723494 0.391929813535768 no 1287 0.394751360936339 1930 588402 SGTC_2621 lithochol-11-enic acid 100 µM 0.26672463833506 0.392021842879835 no 1288 0.394840591145693 1978 6708711 SGTC_249 wiskostatin 11.211 µM 0.26504700410005 0.392688154294258 no 1289 0.395486626098848 1932 2775510 A n-wasp and actin depolymerizer. SGTC_2130 NSC 7 2.4545 µM 0.264180701022383 0.393032349998471 no 1290 0.395820340657836 1943 21448 SGTC_1380 2291-0730 164 µM 0.263947457829698 0.393125035454405 no 1291 0.395910202931026 1796 2999191 SGTC_3144 9087057 49.47 µM 0.263940934740081 0.393127627666623 no 1292 0.395912716180001 2030 17249618 SGTC_149 3970-0822 46.1 µM 0.263528484474111 0.393291540998767 no 1293 0.396071635887889 1819 3114250 YBL034C STU1 SGTC_3115 9123671 49.47 µM 0.262276473101035 0.393789223060261 no 1294 0.396554149525503 1947 3286988 SGTC_1144 3486-0183 12.5 µM 0.260569054487968 0.394468211797493 no 1295 0.397212428193219 1857 6744069 SGTC_2009 4012297 12.05 µM 0.260041063224848 0.394678242980596 no 1296 0.397416049479878 1811 45595307 SGTC_463 ikarugamyin 104 µM 0.260031981927649 0.394681855724272 no 1297 0.397419551951917 1874 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2231 micatex 6.853 µM 0.259843753088216 0.394756739416631 no 1298 0.397492149857418 1886 20737 An antifungal of unknown mechanism. SGTC_3000 9075062 71.4286 µM 0.258490218559522 0.395295334822566 no 1299 0.398014298473091 1831 17057871 SGTC_1085 doxorubicin 7.67 µM 0.257649099946889 0.395630131709787 no 1300 0.398338866176131 1948 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1219 1469-0211 33.1 µM 0.256802970168944 0.395967000951783 no 1301 0.398665438544168 1953 6822282 SGTC_574 1315-0397 40 µM 0.25655695088786 0.396064963083579 no 1302 0.398760405507301 1884 6794277 SGTC_177 1327-0068 8.361 µM 0.255088504907154 0.396649818198796 no 1303 0.399327371153615 1895 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2893 9048488 25.97 µM 0.253138300594596 0.397426908202179 no 1304 0.400080671435904 1777 6467338 SGTC_2490 carminic acid 95.39 µM 0.25276908294184 0.397574074809706 no 1305 0.400223330125515 1881 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2462 5162487 171.77 µM 0.252575301352497 0.397651320123957 no 1306 0.400298208980723 1982 2259986 SGTC_1503 4585-0012 61.3 µM 0.252055153589885 0.397858681521336 no 1307 0.40049921661711 1939 2922052 SGTC_2060 5238662 140 µM 0.251925755782066 0.397910271559683 no 1308 0.400549225633268 1829 790130 SGTC_252 miconazole 1.30953 nM 0.25171194363218 0.397995520941636 no 1309 0.400631862253271 1916 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_544 k015-0020 52.4 µM 0.25132839822162 0.398148457142796 no 1310 0.400780110511289 1849 3008304 SGTC_275 trichlorophene 5.69 µM 0.248552143844153 0.399255935456766 no 1311 0.401853615267774 1877 62616 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.248298307248855 0.399357234272076 no 1312 0.401951804312896 1967 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_356 1634-0012 32.5 µM 0.246901845271754 0.399914642715909 no 1313 0.402492094105927 2028 735457 SGTC_637 1181-0519 7.26 µM 0.246279943785035 0.400162945157562 no 1314 0.402732767214248 1887 6252091 YGR060W ERG25 SGTC_1539 benzyladenosine 56 µM 0.245673991733133 0.400404918401539 no 1315 0.402967303421701 1869 92208 A nucleotide analog. SGTC_2414 st077232 92.9 µM 0.245592395297212 0.400437505015078 no 1316 0.402998888323563 1744 729801 SGTC_1087 pterostilbene 9.05 µM 0.245099572330717 0.400634335096551 no 1317 0.403189667029107 1976 5281727 Similar to reservatol, lowers cholesterol. SGTC_444 curcumin 90.4 µM 0.242249345500634 0.40177318944828 no 1318 0.404293480645703 1924 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_65 0798-0905 34.986 µM 0.240248271476804 0.402573250340468 no 1319 0.405068897020728 2019 3602145 SGTC_1627 st003713 25.6 µM 0.238985289659917 0.403078420702514 no 1320 0.405558494718472 1845 16195070 YER133W GLC7 SGTC_2341 7987486 176.74 µM 0.2370538888867 0.403851259478925 no 1321 0.40630749208356 2026 1258686 SGTC_938 3126-1755 342 µM 0.236627375406186 0.404021977088051 no 1322 0.406472940372235 2021 1777771 SGTC_1093 fluphenazine 7.97 µM 0.236008202859544 0.404269841538977 no 1323 0.406713152497312 1897 6602611 An atypical antipsychotic. SGTC_1386 3228-0095 33.8 µM 0.234636657270083 0.404819029403377 no 1324 0.407245377650516 1966 870181 SGTC_924 2046-0044 21.3 µM 0.234437507509023 0.404898787635944 no 1325 0.407322671528441 1932 3623589 SGTC_383 2324-0395 7.37 µM 0.234285196226793 0.404959790017466 no 1326 0.407381788921529 1938 3146421 SGTC_92 0063-0024 660.874 µM 0.233280016453242 0.405362433671055 no 1327 0.407771987567126 2013 3594437 SGTC_2492 derrusnin 100 µM 0.232786566789155 0.405560130896186 no 1328 0.407963572276147 1886 1715307 Part of coumarin class of compounds. SGTC_1232 0279-0259 161 µM 0.232671411472437 0.40560627055365 no 1329 0.408008285168179 1835 1560000 SGTC_990 3985-0011 41.3 µM 0.232037350677775 0.405860345242323 no 1330 0.408254501860728 1915 5399565 YGL099W LSG1 SGTC_56 0957-0365 83.25 µM 0.231476054588396 0.406085295462055 no 1331 0.408472493001785 1987 6752360 SGTC_2767 sibutramine 71.45 µM 0.230635393445471 0.406422264585173 no 1332 0.40879903439598 2012 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1887 st057648 70.8 µM 0.230483780912283 0.406483044069212 no 1333 0.408857932608755 2016 688672 SGTC_2023 5144124 124 µM 0.229419233373697 0.406909870644106 no 1334 0.409271544352073 1877 2830192 SGTC_950 1165-0508 94.1 µM 0.227534274277591 0.40766590931657 no 1335 0.410004160515299 1846 6148369 SGTC_22 0964-0034 14.468 µM 0.227160230358229 0.407815975671781 no 1336 0.410149575453237 1909 138402 SGTC_2522 biochanin a 4.94 µM 0.226251794707119 0.408180496171229 no 1337 0.410502794248532 1956 5280373 A possible chelator. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.225050798043985 0.408662532165997 no 1338 0.410969878288997 1915 4213774 SGTC_1731 st035964 63 µM 0.224898739772923 0.40872357264873 no 1339 0.41102902485022 1851 6739575 SGTC_1640 st009078 66.4 µM 0.22418716406851 0.409009248625743 no 1340 0.41130583544284 1992 690618 SGTC_2790 5423970 71.43 µM 0.222917339225402 0.409519164641422 no 1341 0.411799920582332 2002 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2818 7996756 12.99 µM 0.220952692378534 0.41030839760079 no 1342 0.412564634289455 1896 2241621 SGTC_1502 4534-4282 27.7 µM 0.220754271212248 0.410388127106753 no 1343 0.412641885702626 1909 3278949 SGTC_920 mycophenolic acid 780.421 nM 0.219765949324879 0.41078530928055 no 1344 0.4130267199101 1869 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3315 9136395 68.55 µM 0.219357827213606 0.410949350199601 no 1345 0.413185659496578 2054 16876844 SGTC_2735 sertaconazole 140 nM 0.218605180649168 0.411251910370883 no 1346 0.413478808417512 2020 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2464 5717415 7.67 µM 0.218510292231713 0.411290058793431 no 1347 0.413515770011474 1836 5285744 SGTC_2710 st078562 53.7235 µM 0.218135351753211 0.411440806023462 no 1348 0.413661826918994 1957 17250908 SGTC_2575 plumbagin 510 nM 0.216925352072854 0.411927383249867 no 1349 0.414133259949073 1841 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1377 2944-0135 198 µM 0.216629625909634 0.412046324250473 no 1350 0.414248497899561 1911 1894137 SGTC_1327 1436-0082 2.18 µM 0.213763097678976 0.413199658473733 no 1351 0.415365901773552 1917 15992205 SGTC_923 1900-2434 73.3 µM 0.213752562260212 0.4132038987386 no 1352 0.415370009862968 1864 5910570 SGTC_965 1291-5240 308 µM 0.212597710019806 0.413668761605045 no 1353 0.415820378877405 2008 2834598 SGTC_3092 9117248 49.47 µM 0.211892594654352 0.413952651357354 no 1354 0.416095414017876 1998 17141857 SGTC_871 0574-0004 149 µM 0.210709912890566 0.414428917227884 no 1355 0.416556819451103 1916 9551173 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.209435786179202 0.41494214877112 no 1356 0.417054029411164 1979 16486 A toxic proline analog. SGTC_348 k064-0012 10.7 µM 0.208906117993494 0.415155547425684 no 1357 0.417260764034477 1902 5066323 SGTC_1506 4226-2149 212 µM 0.207440401466624 0.415746202024483 no 1358 0.417832966464177 1954 991114 SGTC_3300 9124615 50.48 µM 0.207429683537405 0.415750521839542 no 1359 0.417837151288752 2009 24824903 SGTC_1564 D-Arginine 115 µM 0.207406785898445 0.415759750668089 no 1360 0.417846091722518 1838 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_774 k060-0086 136 µM 0.206769807827896 0.416016501481791 no 1361 0.418094818222243 2078 5911235 SGTC_1375 2910-0797 186 µM 0.206743580532228 0.416027073854282 no 1362 0.418105060130846 1940 742508 SGTC_2187 6125751 200 µM 0.204973411393173 0.416740779213248 no 1363 0.418796449299382 1974 874498 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.204319318232956 0.417004569244838 no 1364 0.419051987310615 2015 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2294 7971431 200 µM 0.203651710768687 0.417273848011539 no 1365 0.419312840244396 2007 5741572 SGTC_3285 9112818 20.8695 µM 0.203547593703015 0.417315847021324 no 1366 0.419353524897785 1984 17017947 YPR165W RHO1 SGTC_955 1216-0110 33 µM 0.202497434648674 0.417739515549462 no 1367 0.419763931862436 1907 3619719 SGTC_2864 9034755 47.6 µM 0.200985719553811 0.418349558448037 no 1368 0.420354870186377 2091 4930451 SGTC_1896 st058441 89 µM 0.200962190952812 0.418359054819984 no 1369 0.420364069077497 1901 688759 SGTC_1815 st051655 58.2 µM 0.199577784819293 0.418917898178458 no 1370 0.420905401688837 2076 5984156 SGTC_2089 5281248 129.67 µM 0.198815230966649 0.419225788335017 no 1371 0.421203640621157 1927 2737878 SGTC_2045 5106652 78.05 µM 0.197832772438817 0.419622540510611 no 1372 0.421587952095664 2039 673349 SGTC_2308 7584454 197.62 µM 0.197249779476384 0.419858012749594 no 1373 0.421816038674888 2040 893577 SGTC_2074 5212007 75.395 µM 0.196324180318933 0.420231923354519 no 1374 0.42217821824554 2099 758611 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.195983298209576 0.420369646301671 no 1375 0.422311619296882 1950 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1693 xanthone 101.9 µM 0.195687857280135 0.420489018022949 no 1376 0.422427244574059 2007 7020 An insecticide. SGTC_360 0957-0399 1.01 µM 0.192971510294394 0.421586888454948 no 1377 0.423490640100959 2039 6752301 YPR165W RHO1 SGTC_2373 9071805 200 µM 0.19220875301727 0.421895283348092 no 1378 0.42378934491097 2114 10149009 SGTC_933 2914-0560 114 µM 0.191729728881412 0.42208898492235 no 1379 0.423976958852125 2116 463887 SGTC_1430 4049-0248 69.1 µM 0.191313326601967 0.422257379596318 no 1380 0.424140060403753 2062 22774488 SGTC_193 1273-0060 1.558 µM 0.190363972755945 0.422641355011965 no 1381 0.424511963500083 2069 2847393 YHR072W ERG7 SGTC_2143 5623677 140.463 µM 0.188832244356237 0.423261032339216 no 1382 0.425112149556374 2056 5375313 SGTC_115 0527-0192 112.043 µM 0.188231405958769 0.423504159960603 no 1383 0.425347627049127 1949 4233931 SGTC_2593 nobiletin 86.24 µM 0.188107042593449 0.423554486899145 no 1384 0.425396370228805 1921 72344 An anti-infammatory. SGTC_1540 guanosine 70.6 µM 0.18778333031672 0.423685491514715 no 1385 0.42552325189026 2072 6802 Guanosine is a purine nucleoside SGTC_3005 9076496 71.4286 µM 0.187099053301845 0.423962442483089 no 1386 0.42579148520413 2096 21368410 SGTC_1768 st044301 37.178 µM 0.186514711921061 0.424198975723095 no 1387 0.426020571418701 1947 3931349 SGTC_1282 0886-0010 32.4 µM 0.185517667546208 0.424602628378411 no 1388 0.426411512043115 2086 2836211 YNL267W PIK1 SGTC_723 4182-0001 115 µM 0.183870823984099 0.425269524737187 no 1389 0.427057396815895 1931 744821 YLR208W SEC13 SGTC_718 1130-0073 349 µM 0.182750562539493 0.425723301765406 no 1390 0.427496870298907 2030 6740020 SGTC_2925 9010536 32.5 µM 0.182535441227825 0.425810450837271 no 1391 0.42758127172862 2009 2994177 SGTC_1662 st014054 52 µM 0.18179532339625 0.426110312023259 no 1392 0.427871677378088 2084 2838777 SGTC_1755 st041960 45.185 µM 0.181524137106513 0.426220194750029 no 1393 0.427978094590621 1969 2257073 SGTC_454 lyso-paf C-16 6.67 µM 0.181346738427533 0.426292078513672 no 1394 0.428047711095604 1909 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2448 5185112 27.17 µM 0.181329071150907 0.426299237609432 no 1395 0.428054644381799 1959 5718189 SGTC_2795 7780010 54.55 µM 0.181179626693064 0.426359796141926 no 1396 0.428113292746991 1985 953673 SGTC_3022 9087993 49.47 µM 0.180967827750279 0.426445625203552 no 1397 0.428196414385504 2050 17173644 SGTC_169 k015-0017 16.025 µM 0.180702988166534 0.426552953269807 no 1398 0.428300356592209 2071 1840002 SGTC_515 4092-1064 102 µM 0.180504094003974 0.426633560076305 no 1399 0.428378420317378 2105 717353 SGTC_1077 5-fluorocytosine 377 nM 0.180260009500663 0.426732485579865 no 1400 0.428474224573627 1992 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_975 1335-0046 28.5 µM 0.179721559143289 0.426950731507155 no 1401 0.428685583639121 1909 16486740 SGTC_2232 chlorophetanol 41.5365 µM 0.179675562927333 0.426969375836055 no 1402 0.428703639580838 2078 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2326 6164455 177.58 µM 0.178836033843534 0.427309703243926 no 1403 0.429033225223714 1960 2888790 SGTC_2700 st077718 96.8 µM 0.178793812301029 0.427326820398965 no 1404 0.42904980203246 1943 904970 SGTC_3244 9134489 49.47 µM 0.178589648867795 0.427409592803972 no 1405 0.429129961413379 1948 16584271 SGTC_3049 9092223 49.47 µM 0.177975154228524 0.42765874189129 no 1406 0.429371244131325 1998 8623917 SGTC_2181 6316240 54.2555 µM 0.177836598757077 0.42771492370078 no 1407 0.429425651901452 1940 12779990 SGTC_1258 0671-0043 57.1 µM 0.177082596193884 0.428020684155002 no 1408 0.429721756053348 1950 4298767 SGTC_1491 4138-0063 26.5 µM 0.17702136140258 0.4280455177713 no 1409 0.429745805290538 2101 23883227 SGTC_1084 voriconazole 435 nM 0.176448487056291 0.428277859320141 no 1410 0.429970807503727 2116 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1332 1480-0653 17.5 µM 0.176227120929818 0.428367645792665 no 1411 0.430057757392872 2122 5749438 SGTC_1871 st057448 67.3 µM 0.17585821149059 0.428517284317438 no 1412 0.430202668013501 2066 691747 SGTC_884 0851-0618 334 µM 0.173863567653822 0.429326537218829 no 1413 0.430986342647211 2090 9642473 SGTC_2751 anetholtrithion 17.25 µM 0.172239984975896 0.42998546530005 no 1414 0.431624432059122 2074 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2145 5634607 200 µM 0.171852390142649 0.430142798868833 no 1415 0.431776788390885 1967 308662 SGTC_47 0149-0135 24.25 µM 0.17023102117547 0.43080106942497 no 1416 0.432414228190614 1958 5239155 SGTC_2111 5486399 200 µM 0.169725863332151 0.431006201252325 no 1417 0.432612866585871 2031 689674 SGTC_1758 st042942 75.2445 µM 0.169315390495745 0.43117289760247 no 1418 0.432774285444529 2117 669317 SGTC_2877 9040724 71.43 µM 0.168413441878639 0.43153922928552 no 1419 0.433129017024693 2151 6463895 SGTC_2436 5633522 8.09 µM 0.166662550744545 0.432250531760414 no 1420 0.433817786756883 2133 5724242 SGTC_309 k408-0051 1.48 µM 0.165913428933856 0.432554930987488 no 1421 0.434112539603665 2024 3640463 SGTC_1166 k206-0078 225 µM 0.164604596996719 0.433086859596145 no 1422 0.4346276063486 2031 5404595 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.164189137791259 0.433255733746169 no 1423 0.434791125925975 2029 521171 SGTC_263 alizarin 107.927 µM 0.163630243741781 0.433482929922417 no 1424 0.435011117265578 2086 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_519 k048-0011 62.8 µM 0.163282685184274 0.433624227139111 no 1425 0.435147933082001 2008 6836379 SGTC_3076 9116187 49.47 µM 0.162938252151531 0.433764262067463 no 1426 0.435283526201265 2118 27241210 SGTC_2306 7482397 179.52 µM 0.162208384706665 0.434061029165639 no 1427 0.435570878601676 2102 891448 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.161245372130994 0.434452650879712 no 1428 0.435950073420984 2093 17037758 SGTC_195 4234-0266 16.654 µM 0.159199110699119 0.435285003076911 no 1429 0.43675600224336 2012 2303354 SGTC_1934 st074720 32.6 µM 0.156446701329178 0.436405044883176 no 1430 0.43784046399969 2080 17250992 SGTC_244 nsc-207895 1.295 µM 0.156350756993539 0.436444096898702 no 1431 0.437878274973442 2034 42640 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.156122479962556 0.436537014494872 no 1432 0.437968239591807 2094 616764 SGTC_2805 7950783 58.44 µM 0.155196799526363 0.436913838136952 no 1433 0.438333085663781 2055 1178958 YDL195W SEC31 SGTC_3125 9127534 49.47 µM 0.154934101048887 0.437020787209235 no 1434 0.438436634745318 2159 1639235 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.153629869416463 0.437551830360058 no 1435 0.438950792066551 2122 165506 SGTC_636 0kpi-0074 126 µM 0.151619612803981 0.438370565271554 no 1436 0.439743481735756 2034 616434 SGTC_1381 2324-0066 62.1 µM 0.151617213633401 0.438371542561203 no 1437 0.439744427927994 2040 10885928 SGTC_2421 5690543 90.72 µM 0.151259027128509 0.438517452182884 no 1438 0.439885694476899 2035 3397993 SGTC_261 5-fluorouridine 15.376 µM 0.150771922687598 0.4387158907776 no 1439 0.44007781774322 2129 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_94 0334-0113 514.748 µM 0.150360584863211 0.438883475258997 no 1440 0.440240068204003 2063 6795178 SGTC_2585 alliin 100 µM 0.149757512743073 0.439129194633151 no 1441 0.440477965579363 2075 87310 A garlic compound which reacts with lipids. SGTC_171 k064-0041 9.68 µM 0.14894590230898 0.43945991913854 no 1442 0.44079816017994 2005 53325 SGTC_3229 9132204 49.47 µM 0.14858549610479 0.439606795234041 no 1443 0.440940359194188 2063 17682924 SGTC_2665 lovastatin 100 µM 0.146135195971858 0.440605583755485 no 1444 0.441907331142012 2054 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2742 clothiapine 36.27 µM 0.146124260842506 0.440610041972234 no 1445 0.441911647297192 2163 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1076 itraconazole 331 nM 0.145326558586043 0.440935282862016 no 1446 0.442226523296694 2141 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_163 TUB2.036 7.546 µM 0.143529149547256 0.441668272066755 no 1447 0.442936145781084 2164 15992207 YJR013W GPI14 SGTC_2929 9013348 24.6 µM 0.143313099508384 0.44175639147101 no 1448 0.443021455355967 2060 2995952 SGTC_3061 glucosamine 200 µM 0.143027712489504 0.441872795470566 no 1449 0.443134147397364 2161 91431 and experimental redox chemotherapeutic SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.141311642230121 0.442572853765625 no 1450 0.443811876368815 2090 364106 SGTC_2197 6588183 93.1375 µM 0.138808021511948 0.443594508621497 no 1451 0.444800927552117 2098 884136 SGTC_1719 st032227 49.2 µM 0.138598042481229 0.443680212101672 no 1452 0.444883895127336 2042 3125804 SGTC_99 0109-0120 622.8 µM 0.138028101217814 0.443912848358093 no 1453 0.445109104273617 2143 759414 SGTC_2517 totarol 10 µM 0.13783129727195 0.44399318346827 no 1454 0.445186874386078 2011 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.136222029013206 0.444650170696732 no 1455 0.445822880428971 2146 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_885 0865-0106 16.8 µM 0.136072005301594 0.444711425977661 no 1456 0.445882179095551 2128 2793380 SGTC_2917 7979103 53.79 µM 0.135581932209723 0.444911533973351 no 1457 0.446075894776376 2120 2980565 SGTC_213 1246-0773 967 nM 0.135202475423566 0.44506648446062 no 1458 0.446225894980716 2095 6251622 SGTC_1026 k007-1105 30.6 µM 0.134633387334644 0.445298886271326 no 1459 0.446450871326123 2090 7066794 SGTC_1331 1472-0049 76.2 µM 0.134048206355782 0.445537879633606 no 1460 0.446682227613735 2052 24051409 SGTC_2507 purpurin 79.67 µM 0.133977525731697 0.445566747600234 no 1461 0.44671017303087 2018 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1985 st071382 65.5 µM 0.133787191779199 0.445644486806092 no 1462 0.446785427808849 2195 6123237 SGTC_1778 st046819 58.9 µM 0.132777387838019 0.446056961802524 no 1463 0.447184718944469 2093 671715 SGTC_1329 1447-1697 50.6 µM 0.131157290754271 0.446718845258833 no 1464 0.447825440533886 2086 2840515 SGTC_9 0092-0002 10.449 µM 0.129753372073538 0.447292530122331 no 1465 0.448380777320551 2171 759368 SGTC_3332 9141069 11.198 µM 0.129677339679487 0.447323602483827 no 1466 0.448410855738917 2061 17332883 SGTC_2913 7966556 36.57 µM 0.129652785528347 0.447333637163411 no 1467 0.448420569425527 2167 2976516 SGTC_2347 9049783 174.81 µM 0.129445422095212 0.447418382858607 no 1468 0.448502604176456 2126 6467988 YPL169C MEX67 SGTC_969 1313-0238 134 µM 0.129208406121599 0.44751524995213 no 1469 0.448596372423141 2072 5212874 SGTC_1926 methyl fluorone black 53.6 µM 0.126831865613628 0.448486700788176 no 1470 0.449536737142056 2156 72721 Reacts with homocysteine. SGTC_468 gf-109203x 121 µM 0.126500625378936 0.448622125461073 no 1471 0.449667827021441 2175 2396 A protein kinase C inhibitor. SGTC_79 0052-0007 94.094 µM 0.126339722136763 0.448687911505748 no 1472 0.449731507218726 2161 2801472 SGTC_691 1548-0686 185 µM 0.125972509429684 0.448838053423402 no 1473 0.449876842744762 2062 46495133 SGTC_3129 9127257 49.47 µM 0.125243245911884 0.449136248423095 no 1474 0.450165490735525 1948 837894 SGTC_2905 7799065 20.05 µM 0.124227832516034 0.449551497591283 no 1475 0.450567442881729 2178 1296806 SGTC_835 0312-0010 67.2 µM 0.12371065465 0.449763016636947 no 1476 0.450772187639507 2120 1626196 SGTC_2128 5255449 168.493 µM 0.123543191548062 0.449831509937813 no 1477 0.450838487162179 2138 736008 SGTC_3175 9106517 49.47 µM 0.123364795540268 0.449904476499495 no 1478 0.450909116588657 2083 41468073 SGTC_823 0417-1665 178 µM 0.12316875283095 0.449984662771894 no 1479 0.450986734378897 2098 3429856 SGTC_1286 0929-0070 131 µM 0.123084177882116 0.45001925662929 no 1480 0.451020220113418 2129 1420408 SGTC_5 0352-0601 109.883 µM 0.122629963525381 0.450205051310143 no 1481 0.4512000630268 2104 762456 SGTC_251 melphalan 456.522 µM 0.122256528670485 0.450357811615435 no 1482 0.451347929381678 2121 460612 A DNA alkylator. SGTC_1343 1487-0095 224 µM 0.120721786567813 0.450985702712064 no 1483 0.451955701008124 2203 4560101 YGL055W OLE1 SGTC_1456 k015-0012 13 µM 0.118790875239459 0.451775847961558 no 1484 0.452720518999376 2217 2989616 SGTC_1905 st060207 84.5 µM 0.118125534747112 0.452048155340106 no 1485 0.452984095645714 2058 1948547 SGTC_1962 st076595 64.5 µM 0.118085102612502 0.452064703939442 no 1486 0.453000113626871 2161 279619 SGTC_1708 st033234 31.827 µM 0.117157242750647 0.452444493536152 no 1487 0.45336772442758 2163 674664 SGTC_511 blebbistatin 171 µM 0.116447756558906 0.452734928270438 no 1488 0.453648844271322 2185 3476986 A myosin inhibitor. SGTC_2604 4'-hydroxychalcone 11.32 µM 0.115205582436427 0.453243484541399 no 1489 0.454141086998413 2097 5282362 SGTC_216 k038-0035 28.382 µM 0.11504666973835 0.453308550253689 no 1490 0.454204065248875 2191 4444231 YPR107C YTH1 SGTC_2040 5100729 123 µM 0.11259224069444 0.454313657490938 no 1491 0.45517691848014 2132 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_100 0086-0128 49.5915 µM 0.112274702021793 0.454443713490635 no 1492 0.455302799910426 2026 93297 SGTC_3102 9121669 49.47 µM 0.112150926261189 0.454494410309677 no 1493 0.455351869385602 2105 41905072 SGTC_917 harmaline 728.087 nM 0.11200166625201 0.45455554610611 no 1494 0.455411042703611 2137 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2686 alizarin 95.37 µM 0.111691419052125 0.454682624508605 no 1495 0.455534041680453 2099 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1223 0764-0573 147 µM 0.110644491341188 0.455111484136739 no 1496 0.455949132537557 2174 1609797 SGTC_769 0302-0231 76 µM 0.109894464347538 0.45541875464107 no 1497 0.456246536382417 2190 571869 YER009W NTF2 SGTC_1709 st033179 39.1045 µM 0.108900049843548 0.455826186732147 no 1498 0.456640883555754 2214 573381 SGTC_1977 st070720 65.3 µM 0.108619611233526 0.455941096620038 no 1499 0.45675210263634 2088 682188 SGTC_96 0929-0093 37.281 µM 0.108374012034519 0.456041734065882 no 1500 0.456849507546348 2078 6991579 SGTC_273 hydroxyurea 18.1 mM 0.108177133033635 0.456122409817721 no 1501 0.456927591845131 2208 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1618 st003135 44.5 µM 0.107137724073555 0.45654836173289 no 1502 0.457339859952733 2214 1270615 SGTC_2837 9008476 45.46 µM 0.106935463685361 0.456631254272204 no 1503 0.457420089267321 2146 2992805 SGTC_628 1636-0253 16 µM 0.106914012095473 0.456640045905483 no 1504 0.457428598432001 2197 4456143 SGTC_2470 5664817 21.68 µM 0.106495452325831 0.456811590999258 no 1505 0.457594631705015 2247 2859561 SGTC_1320 1313-0481 95.3 µM 0.105974512188361 0.45702510752768 no 1506 0.457801287308362 2198 6813365 YLR208W SEC13 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.105583777879509 0.457185265040577 no 1507 0.457956298087721 2164 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1297 1068-0111 14.1 µM 0.104469575792896 0.457642001800162 no 1508 0.458398355570229 2146 767057 SGTC_3235 9132602 49.47 µM 0.104016187246969 0.457827872118715 no 1509 0.458578251343227 2152 4912240 SGTC_532 1548-0774 215 µM 0.103088406075461 0.458208252253601 no 1510 0.458946403304309 2231 5932993 SGTC_219 mitoxanthrone 164.414 µM 0.101457645999213 0.458876938608812 no 1511 0.459593588803979 2184 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2098 5376439 882.5 nM 0.101417123201843 0.458893556302205 no 1512 0.459609672103053 2182 2844116 SGTC_146 3448-8650 53.125 µM 0.10108186703823 0.459031041768355 no 1513 0.459742736159427 2109 2891488 YIL048W NEO1 SGTC_2031 5180455 200 µM 0.100850177047465 0.459126058564961 no 1514 0.459834697164304 2221 29949 SGTC_429 1112-0049 25.5 µM 0.0984478619748101 0.460111392190033 no 1515 0.460788335436727 2034 2836170 SGTC_2206 7254556 146.969 µM 0.0977148915988687 0.460412076403966 no 1516 0.461079345181163 2229 4398905 SGTC_2135 5326629 150.42 µM 0.0977108103783699 0.460413750694208 no 1517 0.46108096559837 2137 5020077 SGTC_524 r073-0010 27.8 µM 0.0972992306331358 0.460582601811462 no 1518 0.461244383484425 2099 2772106 SGTC_3006 9075424 71.4286 µM 0.0966095973661128 0.46086554065902 no 1519 0.461518217277357 2147 7465181 SGTC_3003 9075612 71.4286 µM 0.09648665068976 0.460915984613093 no 1520 0.46156703783229 2166 6501993 SGTC_632 0781-2353 4.65 µM 0.0958716740768724 0.461168313603452 no 1521 0.461811245869808 2176 6811515 YHR007C ERG11 SGTC_2906 7926292 26.41 µM 0.095495402342226 0.461322708111993 no 1522 0.46196067098597 2125 2966319 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.094938849097832 0.461551087700433 no 1523 0.46218169937422 2218 140250 A respiratory chain inhibitor. SGTC_2655 perillic acid 100 µM 0.0945419081410659 0.461713978721152 no 1524 0.462339346812546 2147 5702197 An apoptosis inducer. SGTC_1907 st060210 83.7 µM 0.0924352774030292 0.462578574913362 no 1525 0.463176106040708 2209 688793 SGTC_1853 st056710 91.2 µM 0.0908785955943043 0.463217576786965 no 1526 0.463794529021854 2269 269167 SGTC_3281 9140613 49.47 µM 0.0907917122998307 0.463253244297776 no 1527 0.463829047739907 2047 16013766 SGTC_3025 9087895 49.47 µM 0.0903508838277517 0.46343421866504 no 1528 0.464004193006838 2251 17173641 SGTC_1722 st034304 3.6505 µM 0.0896907674519345 0.463705231958696 no 1529 0.464266476438883 2181 4036148 YLR033W RSC58 SGTC_2858 9025781 8.96 µM 0.0885988248546269 0.46415357006866 no 1530 0.464700371021987 2249 4894980 YPL153C RAD53 SGTC_1818 st052136 56.3 µM 0.0877168906975669 0.464515714571508 no 1531 0.465050847267858 2174 674169 SGTC_751 0833-0568 350 µM 0.0873002974179128 0.464686788564879 no 1532 0.465216408809727 2177 6954252 SGTC_2754 granisetron 64.02 µM 0.0863608896676606 0.465072580183137 no 1533 0.465589768128886 2232 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2849 9019321 12.99 µM 0.0863021448577216 0.465096706323784 no 1534 0.46561311674485 2202 16489627 SGTC_1463 k081-0032 34.1 µM 0.0840051413481083 0.466040171584626 no 1535 0.466526172007751 2208 977755 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.0829476657597234 0.466474580852562 no 1536 0.466946576402187 2101 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_594 1487-1584 10.8 µM 0.0822436341057791 0.466763818102171 no 1537 0.467226487975509 2206 5013332 SGTC_1138 3761-0006 1.03 µM 0.0816204503363405 0.467019855273616 no 1538 0.467474269267827 2254 12061087 SGTC_3186 9110464 49.47 µM 0.0812384369672602 0.467176813519477 no 1539 0.46762616612043 2250 17018021 SGTC_1130 3454-2858 15.9 µM 0.0808154747305437 0.467350602423769 no 1540 0.46779435063467 2102 715628 YIL048W NEO1 SGTC_1226 3909-7979 35.4 µM 0.0801643790741061 0.467618140116634 no 1541 0.468053260166878 2252 6615510 SGTC_427 1354-0053 47.3 µM 0.0800261924220218 0.467674923425776 no 1542 0.468108212116559 2202 6813657 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.0793501869414498 0.467952715343983 no 1543 0.468377044352667 2125 61125 An anti-inflammatory. SGTC_2977 9011197 71.43 µM 0.0787499309944242 0.468199392481444 no 1544 0.468615764787515 2250 2704722 SGTC_1094 duloxetine 25.4 µM 0.0786358055125476 0.468246294104488 no 1545 0.468661153513313 2261 60834 A selective serotonin reuptake inhibitor. SGTC_3067 9117431 49.47 µM 0.0780037574190244 0.468506051957005 no 1546 0.468912532056889 2179 17150885 SGTC_2746 daunorubicin 9.88 µM 0.0759900016301884 0.469333750134817 no 1547 0.469713526370751 2262 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2108 5365811 200 µM 0.0754803508090035 0.469543249055259 no 1548 0.469916265357967 2228 780283 SGTC_816 0325-0417 81.3 µM 0.0749900703453981 0.469744793484203 no 1549 0.470111306181957 2177 68101 SGTC_841 0251-0215 91.2 µM 0.0743185636166806 0.470020848951781 no 1550 0.470378453123782 2204 3888614 SGTC_3149 9097855 49.47 µM 0.0732062324498332 0.470478158363297 no 1551 0.470821003460037 2272 25236625 YMR079W SEC14 SGTC_1806 st050005 60.3 µM 0.0728643349160569 0.470618729533042 no 1552 0.470957037543624 2168 5194765 SGTC_470 aa-861 153 µM 0.0728512334495062 0.470624116273914 no 1553 0.47096225041855 2174 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2724 maprotiline 69.64 µM 0.0728497137172619 0.470624741120631 no 1554 0.470962855097294 2264 4011 A tricyclic antidepressant. SGTC_447 ml7 120 µM 0.0727477307909134 0.4706666721568 no 1555 0.471003432732179 2284 4216 Selective myosin light chain kinase inhibitor. SGTC_2428 5615643 7.78 µM 0.0723776012450661 0.470818856392048 no 1556 0.471150704826726 2229 2253075 SGTC_739 1486-1183 203 µM 0.0723725636238321 0.470820927713948 no 1557 0.471152709290106 2292 4346692 SGTC_593 1203-0218 61.7 µM 0.0721926683611801 0.470894895879557 no 1558 0.471224289875576 2291 3666956 SGTC_514 4466-0038 2.65 nM 0.0718428972913154 0.471038715347997 no 1559 0.471363466949509 2162 5722064 SGTC_1500 4488-1866 171 µM 0.0716647958766279 0.471111948845693 no 1560 0.471434336459012 2270 2900003 SGTC_3170 9103054 49.47 µM 0.0697056859473733 0.471917578935588 no 1561 0.472213958030649 2211 16432970 SGTC_1395 3486-0190 4.35 µM 0.0690677772854735 0.472179926293103 no 1562 0.472467834879041 2286 6748079 SGTC_939 1165-0479 45.3 µM 0.0664710031526982 0.473248003240506 no 1563 0.473501421384946 2299 1377347 SGTC_2841 9004761 38.96 µM 0.0656634843532186 0.473580182676436 no 1564 0.47382287245368 2205 2991039 SGTC_2102 5377816 72.7585 µM 0.0655733577412531 0.473617258136293 no 1565 0.473858750445246 2274 1379702 SGTC_2365 9042475 200 µM 0.0655101054572099 0.473643278417855 no 1566 0.473883930314739 2216 6464479 SGTC_2937 9044753 11.33 µM 0.0650219404965656 0.473844100074617 no 1567 0.4740782656138 2287 6465530 YGL099W LSG1 SGTC_3202 9113761 49.47 µM 0.0642361082606032 0.474167390252595 no 1568 0.474391113258902 2267 4798415 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.0625658404162451 0.474854592128861 no 1569 0.475056115750652 2278 2333 A French combination drug. SGTC_1279 0874-0590 65.2 µM 0.0621670570135612 0.475018675578799 no 1570 0.475214898211128 2239 3523074 SGTC_387 norethindrone acetate 66.7 µM 0.0613619568965672 0.475349955019216 no 1571 0.475535474619419 2223 541197 SGTC_622 1348-1566 26.3 µM 0.0604468768375004 0.475726509255263 no 1572 0.475899862284815 2248 7340407 SGTC_2794 7785382 27.27 µM 0.0592019511438648 0.4762388292806 no 1573 0.476395627791168 2326 2205081 SGTC_50 0929-0078 56.389 µM 0.0591820339946672 0.476247026038598 no 1574 0.476403559676468 2229 1377751 SGTC_209 4077-0173 175.592 µM 0.0589550924493218 0.476340422891084 no 1575 0.476493938446217 2246 15993494 SGTC_1674 st016616 23.6 µM 0.0587697472996494 0.476416701883821 no 1576 0.4765677524771 2304 625830 SGTC_2479 5617353 43.85 µM 0.0582428164548978 0.476633565542811 no 1577 0.47677760799382 2288 2731746 SGTC_2481 5478948 45.16 µM 0.057942784167145 0.476757049927792 no 1578 0.476897101756044 2229 77792 SGTC_997 3996-0078 137 µM 0.0571033284184795 0.477102556820528 no 1579 0.477231442528653 2259 735687 SGTC_103 0844-0104 51.839 µM 0.0554121103527767 0.477798687803114 no 1580 0.477905073997832 2305 5375804 SGTC_2981 9013952 38.96 µM 0.0547164843060908 0.478085037808434 no 1581 0.478182168229531 2138 2996344 SGTC_2099 5377090 177.372 µM 0.0541492195682987 0.478318557084903 no 1582 0.478408139097955 2247 2243829 SGTC_538 2922-0838 53.3 µM 0.0541238925505418 0.478328983337895 no 1583 0.478418228320758 2313 777039 SGTC_499 genistein 192 µM 0.0539969567464463 0.478381238620187 no 1584 0.47846879443538 2315 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2806 7952793 58.44 µM 0.0538054430307713 0.478460079200982 no 1585 0.478545086446096 2269 2972490 SGTC_865 0488-0499 301 µM 0.0529595776761699 0.47880830720418 no 1586 0.478882057415515 2322 9634651 SGTC_114 0364-0001 490.298 µM 0.0519727261298637 0.479214597189981 no 1587 0.479275212714605 2186 4003655 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.0519587648845378 0.479220345235945 no 1588 0.479280774930368 2298 6710655 SGTC_2569 tetrandrine 100 µM 0.0510869507727653 0.479579292186134 no 1589 0.47962811709502 2206 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_572 0960-0087 17.7 µM 0.0505166932286115 0.479814089983182 no 1590 0.479855323557704 2297 6796365 SGTC_874 0599-0792 117 µM 0.0502306851324296 0.479931853577094 no 1591 0.479969279605438 2308 765305 SGTC_1575 cyproterone acetate 48 µM 0.0498625420183164 0.480083438772799 no 1592 0.480115963645913 2263 9880 An androgen receptor antagonist and liver toxin. SGTC_1860 st056228 74.6 µM 0.0484092044503445 0.480681887391489 no 1593 0.48069506190813 2219 688679 SGTC_2095 5432005 200 µM 0.0471954973334604 0.481181695513556 no 1594 0.481178708066243 2317 783734 SGTC_2992 9074591 71.4286 µM 0.0459950724048998 0.481676063093479 no 1595 0.481657088703007 2338 17741321 SGTC_989 1501-0895 10.3 µM 0.0459594058315362 0.481690751991646 no 1596 0.481671302575776 2335 2830112 SGTC_364 0083-0097 67.7 µM 0.0451866367389348 0.482009014777457 no 1597 0.481979272854259 2269 5207356 SGTC_577 r071-0003 38.6 µM 0.0447780524722609 0.482177293709729 no 1598 0.482142109566023 2326 4568517 YMR134W ERG29 SGTC_1322 1348-1070 12 µM 0.0437845733255442 0.482586479799427 no 1599 0.48253806199709 2308 6758089 SGTC_2706 st078239 82.5 µM 0.0437688366724592 0.482592961432493 no 1600 0.482544334000643 2339 15434492 SGTC_2828 7998861 71.43 µM 0.0437506615549761 0.48260044742916 no 1601 0.482551577884424 2322 2988188 SGTC_3136 9095672 49.47 µM 0.0434815134570384 0.482711305297927 no 1602 0.48265885035592 2349 17217380 SGTC_2220 6782180 200 µM 0.043309235097258 0.482782264747132 no 1603 0.482727514794092 2322 833803 SGTC_27 0485-0001 32.618 µM 0.0417958400321146 0.483405637731545 no 1604 0.483330725645212 2324 2054479 SGTC_2259 7964009 200 µM 0.0412200021914054 0.483642838189266 no 1605 0.483560253890197 2286 313134 SGTC_3 0833-0587 95.581 µM 0.0407457512686969 0.483838197079328 no 1606 0.48374929381097 2255 5382644 SGTC_1086 cerivastatin 2.18 µM 0.0392102496306507 0.484470744937412 no 1607 0.484361380949206 2351 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_888 0916-0002 6.97 µM 0.0384043060388663 0.484802768069369 no 1608 0.484682663896958 2328 2802138 YIL048W NEO1 SGTC_2258 7960471 200 µM 0.0362570075179433 0.4856874375921 no 1609 0.485538715206278 2223 2974708 SGTC_2322 7413319 38.22 µM 0.0347930267973456 0.486290626392007 no 1610 0.48612239053813 2307 1840400 SGTC_2402 5553605 200 µM 0.0347193108557811 0.486320999648244 no 1611 0.486151781186768 2320 6758546 SGTC_3293 9120939 62.045 µM 0.0340464293470387 0.486598251363598 no 1612 0.486420063439178 2329 934087 SGTC_448 monastrol 171 µM 0.0337261091456408 0.486730237249739 no 1613 0.486547779362411 2302 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_200 k038-0079 37.545 µM 0.0334018930375307 0.486863829899366 no 1614 0.486677050040412 2290 3436683 SGTC_2968 9090663 33.37 µM 0.0328153465263295 0.48710551904346 no 1615 0.486910920022786 2243 25236811 SGTC_3335 9143315 29.6265 µM 0.0327202867364409 0.487144689308337 no 1616 0.486948823037863 2287 4899691 SGTC_688 0527-0193 473 µM 0.0311661273143954 0.487785112374702 no 1617 0.487568526635792 2316 4007154 SGTC_830 4076-0286 57.8 µM 0.031079923301696 0.487820635432361 no 1618 0.487602900409203 2326 6866659 SGTC_3319 9138450 16.7555 µM 0.0307226362700521 0.487967867747455 no 1619 0.487745369274384 2261 2029690 SGTC_3183 9108214 49.47 µM 0.0284516728950333 0.488903733210086 no 1620 0.488650955925501 2354 4974831 SGTC_1803 st050068 52.4 µM 0.0283116289660887 0.488961447455801 no 1621 0.488706802872432 2359 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_210 3551-0445 56.827 µM 0.028127990483348 0.489037128034191 no 1622 0.488780034862169 2319 2865180 YOR207C RET1 SGTC_1642 st009582 77.7 µM 0.0280560041743437 0.48906679493856 no 1623 0.488808741914966 2341 6739311 SGTC_2336 9001819 198.65 µM 0.0276223637123576 0.489245507557659 no 1624 0.488981672403097 2342 2989602 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.0275535310980214 0.489273875167176 no 1625 0.489009122195286 2347 94937 An inhibitor of serotonin biosynthesis. SGTC_2401 5128683 200 µM 0.0260187165322221 0.489906423743206 no 1626 0.489621204935121 2342 708373 SGTC_2196 6573537 42.6665 µM 0.0255834209201468 0.490085828359495 no 1627 0.489794804965914 2358 2903087 SGTC_2321 7390090 138.78 µM 0.0237838926651906 0.49082751460135 no 1628 0.490512494103615 2335 649046 SGTC_977 1348-1378 135 µM 0.0222201256352228 0.491472056302566 no 1629 0.49113618180899 2368 X977 SGTC_2360 9040895 200 µM 0.0196367416429894 0.492536904012339 no 1630 0.492166576942634 2347 4914414 SGTC_101 0490-5701 117.494 µM 0.0190215658036317 0.492790482099995 no 1631 0.492411950748872 2364 4661669 SGTC_2432 5630864 12.22 µM 0.0180665913790584 0.493184132338758 no 1632 0.49279286490851 2360 5714970 SGTC_1080 nisoldipine 24.4 µM 0.017127248398986 0.4935713456136 no 1633 0.493167550509799 2382 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2617 dihydrotanshinone i 20.83 µM 0.0168099894901629 0.493702126559598 no 1634 0.493294100281528 2375 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2953 9074162 66.49 µM 0.0167829720840035 0.493713263746998 no 1635 0.49330487714685 2379 16451992 SGTC_777 1315-0167 517 µM 0.0162935994011988 0.493914995102361 no 1636 0.493500081901417 2293 4221767 SGTC_2452 5863136 48.41 µM 0.0162931017843178 0.493915200232977 no 1637 0.493500280395481 2374 2184096 SGTC_2353 9059630 146.67 µM 0.0161006431993948 0.493994536785456 no 1638 0.493577050191611 2355 4779114 SGTC_745 0469-0705 296 µM 0.0159052578285588 0.49407508007998 no 1639 0.493654987696566 2376 3486736 SGTC_812 4251-0442 148 µM 0.0148324209269342 0.494517337563521 no 1640 0.494082937132003 2380 5723007 SGTC_2821 7996764 71.43 µM 0.0148002119125316 0.49453061525031 no 1641 0.494095785259349 2365 2987135 SGTC_2466 5983409 37.09 µM 0.0141068998829536 0.494816424259828 no 1642 0.494372347846719 2305 2879657 SGTC_189 3970-0742 2.116 µM 0.0137214756313743 0.494975311634096 no 1643 0.494526094991816 2385 2891807 SGTC_949 1165-0505 146 µM 0.0131067437960318 0.495228730453955 no 1644 0.494771315444909 2370 6244267 SGTC_2168 5727979 200 µM 0.0125656674760583 0.495451786908927 no 1645 0.494987155880687 2380 695210 SGTC_1841 st054148 70 µM 0.0122325707375937 0.495589105360923 no 1646 0.49512003203805 2354 675442 SGTC_1728 st035614 33.7865 µM 0.0115404179501384 0.495874445590443 no 1647 0.495396141537681 2325 15945546 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.0114854587235142 0.495897102643276 no 1648 0.495418065643833 2350 688788 SGTC_3062 9077494 49.47 µM 0.0113288311515649 0.495961672750379 no 1649 0.495480546939239 2361 16459633 SGTC_625 k213-0058 121 µM 0.0106918292321152 0.496224279452383 no 1650 0.495734658530201 2374 3655420 SGTC_799 1310-0557 151 µM 0.0104210335456684 0.496335916607429 no 1651 0.495842684359273 2342 5354492 SGTC_2082 5219693 150 µM 0.0103894859819395 0.496348922299684 no 1652 0.495855269334985 2388 2834649 SGTC_2718 lomofungin 53.02 µM 0.0101816543655713 0.49643460235746 no 1653 0.49593817776813 2374 5351222 A RNA synthesis inhibitor. SGTC_1685 st024049 53.0905 µM 0.0100200081843042 0.496501242255976 no 1654 0.49600266197459 2357 1941139 SGTC_70 0141-0289 43.283 µM 0.0098301856914192 0.496579498183138 no 1655 0.496078386462851 2332 352408 SGTC_2919 7978188 46.38 µM 0.00923128946785136 0.496826399062013 no 1656 0.496317300633308 2388 2980291 SGTC_1041 0206-0046 107 µM 0.00899902591072145 0.496922152338058 no 1657 0.496409956536947 2319 50494 SGTC_394 menadione 8.33 µM 0.00877909101634628 0.497012823147106 no 1658 0.496497694398684 2395 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_861 0443-0273 110 µM 0.00852392862784062 0.49711801710793 no 1659 0.496599485654012 2349 6149169 SGTC_1427 4048-4900 550 nM 0.00790955860224354 0.497371299823135 no 1660 0.496844575555433 2387 24132586 SGTC_2397 5161689 200 µM 0.00676074521829338 0.497844917120505 no 1661 0.497302873431981 2385 2259942 SGTC_1670 st016595 4.04 µM 0.00635787521662935 0.49801100768819 no 1662 0.497463591850607 2395 597879 SGTC_3027 9089541 49.47 µM 0.00558734589123112 0.498328673509859 no 1663 0.497770983086503 2387 9943819 SGTC_1994 st072947 40.9 µM 0.0055177683314123 0.498357358278229 no 1664 0.497798740088986 2356 5286565 YDL195W SEC31 SGTC_1560 lithocholic acid 53.1 µM 0.00509787275354321 0.498530468970778 no 1665 0.497966251827454 2397 9903 A bile acid which acts as a detergent. SGTC_1744 st037937 38.9 µM 0.00486962779485955 0.498624567824321 no 1666 0.49805730726075 2392 1016152 SGTC_1874 staurosporine 7.6 µM 0.0043462014576306 0.49884036177894 no 1667 0.498266121938083 2392 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_3151 9099821 49.47 µM 0.00402755293636208 0.498971731770716 no 1668 0.498393243191047 2397 17174189 SGTC_300 r073-0011 5.04 µM 0.00399313714757943 0.498985920457606 no 1669 0.498406972993898 2389 2735780 SGTC_3256 9138902 49.47 µM 0.00263241906564285 0.499546908088911 no 1670 0.498949817947876 2400 17228773 SGTC_390 dec-rvkr-cmk 16.7 µM 0.00257169356369075 0.49957194361653 no 1671 0.498974043836086 2400 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2036 5160441 105 µM 0.00208949360639462 0.499770742030747 no 1672 0.499166413262352 2401 134534 YIL048W NEO1 SGTC_147 4466-0538 29.23 µM 0.0020783953492114 0.499775317552395 no 1673 0.499170840816767 2396 6742687 YHR072W ERG7 SGTC_2885 9057732 51.95 µM 0.00180069366590363 0.499889806713344 no 1674 0.49928162755084 2395 6471414 SGTC_2380 9035439 200 µM 0.00153341195531305 0.5 no 1675 0.49938825737749 2398 6462575 SGTC_2870 9038528 12.99 µM 0.000681056895840649 0.499648596253584 no 1676 0.499728297629895 2397 6463316 SGTC_1278 0874-0585 172 µM 0.000431105219248122 0.499545547740038 no 1677 0.499828013906068 2402 766306 SGTC_2398 5228213 48.84 µM 0.000320865259991107 0.499500098708517 no 1678 0.499871993283674 2404 80771 YMR134W ERG29 SGTC_1677 st019204 53.9 µM 0.000219628574440501 0.499458361495302 no 1679 0.499912380876376 2403 3945625 SGTC_2282 7944268 200 µM 0 0.49936781445236 no 1680 0.5 2406 2970414 SGTC_1006 4099-6547 255 µM -0.000413106571601079 0.499197501648665 no 1681 0.499835194326964 2406 3146833 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.000806192960443336 0.499035442766832 no 1682 0.499678375576757 2407 66535 A nucleotide analog. SGTC_2755 lomerizine 42.69 µM -0.00111246197130361 0.498909176449757 no 1683 0.499556191975849 2406 3949 A calcium channel blocker. SGTC_1940 st075990 51.1 µM -0.00123802410105413 0.498857410656703 no 1684 0.499506099968101 2419 1084979 SGTC_662 k832-1615 104 µM -0.00138298851731789 0.498797645861568 no 1685 0.499448267583011 2409 5878478 SGTC_1672 st016598 6.51 µM -0.00173651949411261 0.498651894992814 no 1686 0.499307229301232 2413 4665860 YNL267W PIK1 SGTC_1152 3909-8331 15.9 µM -0.00200308698245011 0.498541996839998 no 1687 0.499200884445768 2410 16001939 SGTC_3207 9114163 49.47 µM -0.00229172628216788 0.498422999235528 no 1688 0.499085734291225 2417 849233 SGTC_455 paf C-16 10 µM -0.00259115576739235 0.498299553299214 no 1689 0.49896627956603 2410 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_421 streptovitacin 30 mM -0.00323773018095763 0.49803299032912 no 1690 0.498708334795017 2443 91467 include heat shock SGTC_176 1486-1328 72.834 µM -0.00351751621898059 0.497917643318447 no 1691 0.498596716952036 2420 22310231 SGTC_271 rotenone 740 µM -0.00403989442821223 0.497702283635551 no 1692 0.4983883196882 2434 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1600 coumarin 106 71.1 µM -0.00478649921559461 0.497394483746396 no 1693 0.498090470379197 2440 100336 A hepatotoxic, DNA x-linker. SGTC_2757 clomiphene 4.22 µM -0.00499266254348828 0.497309489848247 no 1694 0.498008224094356 2413 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2523 spermine 47.74 µM -0.00639898163216198 0.496729717345569 no 1695 0.497447193097047 2416 1103 A DNA binding polyamine. SGTC_941 3237-0776 460 µM -0.00723368958836959 0.496385601816378 no 1696 0.497114200547106 2422 760008 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.0074225740880877 0.496307732921899 no 1697 0.497038848557453 2432 5393153 SGTC_1516 st013856 110 µM -0.00781831140888103 0.496144588032287 no 1698 0.49688097679325 2471 5281404 A mutagen and neurotoxin. SGTC_2203 7227154 166.4 µM -0.00828927426240965 0.495950431845131 no 1699 0.496693095893628 2420 896304 SGTC_2018 5133068 143 µM -0.00878053815340391 0.495747907502649 no 1700 0.496497117096777 2424 785362 SGTC_417 st075190 100 µM -0.00958818248909052 0.495414957210588 no 1701 0.496174927221545 2421 222757 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.00990266902076379 0.495285311411705 no 1702 0.496049471205589 2412 23665772 A membrane-active detergent. SGTC_2409 alverine citrate 63.97 µM -0.0108562671220899 0.49489219755776 no 1703 0.495669061110853 2508 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2689 tacrolimus 100 µM -0.011132622442397 0.494778273005085 no 1704 0.495558817952697 2432 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2555 cholic acid 100 µM -0.0113522047372182 0.494687752833799 no 1705 0.495471222827271 2499 6708657 Influences liver metabolism. SGTC_202 3594-0513 34.79 µM -0.0119876621190185 0.494425794696226 no 1706 0.495217729276438 2419 708429 SGTC_1180 1193-0155 285 µM -0.012076278608321 0.494389264015428 no 1707 0.49518237897102 2443 2921347 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.012093231285303 0.494382275560321 no 1708 0.495175616325237 2444 1609 A potent and irreversible inhibitor of serine proteases. SGTC_3034 9090421 49.47 µM -0.0129728994524995 0.494019649613463 no 1709 0.494824707073029 2414 17173761 SGTC_1804 st050076 49.1 µM -0.0130954607535457 0.493969126506604 no 1710 0.494775816341327 2429 3895976 SGTC_2059 5238311 157 µM -0.0138851723521432 0.493643588229045 no 1711 0.494460795669904 2427 703021 SGTC_3066 9117245 49.47 µM -0.0145730598844096 0.493360027743675 no 1712 0.494186396034476 2436 17176980 SGTC_430 0958-0115 16.4 µM -0.0151353816347479 0.493128230377167 no 1713 0.493962086864067 2454 6833180 SGTC_3325 9138760 55.175 µM -0.0162417516197061 0.492672175105724 no 1714 0.493520763436863 2443 43844959 SGTC_2712 st079126 47.7 µM -0.0166693399744356 0.492495922023287 no 1715 0.493350203458958 2433 3152970 SGTC_229 benomyl 22.8748 µM -0.0176300757668828 0.492099909513497 no 1716 0.492966981705086 2457 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2723 salbutamol 83.58 µM -0.0190381032947883 0.491519538823756 no 1717 0.492405354438922 2435 9884233 β2-adrenoceptor agonist SGTC_2165 5727197 32.143 µM -0.0200552847993825 0.491100280895423 no 1718 0.491999635262011 2545 1361712 SGTC_1736 st036774 51 µM -0.0201630647762117 0.491055857130522 no 1719 0.491956645965155 2434 1272247 SGTC_781 4335-2806 94.4 µM -0.0204400164815503 0.490941706220235 no 1720 0.491846180987176 2498 845254 SGTC_1454 4239-0054 42.6 µM -0.0212637750305889 0.490602182895682 no 1721 0.49151762031952 2498 1340767 SGTC_3152 9099253 49.47 µM -0.0223413822459929 0.490158042698186 no 1722 0.491087819426012 2466 25236131 SGTC_2277 7947813 106.88 µM -0.022529721868762 0.49008041899373 no 1723 0.49101270169531 2583 1246798 SGTC_855 0428-0020 25 µM -0.0233867401676207 0.489727205833711 no 1724 0.49067089096401 2467 6812414 SGTC_3276 9139060 49.47 µM -0.0243613524097534 0.489325537086528 no 1725 0.490282187739397 2450 4870619 SGTC_2994 9053520 71.4286 µM -0.0245420583466317 0.48925106359186 no 1726 0.490210118048901 2460 4647384 SGTC_295 k015-0027 31 µM -0.0248850607464217 0.489109704646062 no 1727 0.490073321671275 2485 3887424 SGTC_1106 tegaserod maleate 11.7 µM -0.025241677613627 0.488962736325073 no 1728 0.489931096803685 2472 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1653 st012112 65 µM -0.0254112892996051 0.488892836777708 no 1729 0.489863453228794 2464 720429 SGTC_3329 9141233 27.5565 µM -0.0263963353153056 0.488486891191886 no 1730 0.489470608563836 2478 4909101 YNL103W MET4 SGTC_2647 atorvastatin 60.16 µM -0.0276939079133791 0.487952169095847 no 1731 0.488953141311236 2479 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_850 0388-0143 75.9 µM -0.0282686826274777 0.48771531465432 no 1732 0.488723929127966 2465 67273 SGTC_1911 st060208 74.3 µM -0.0289257209873632 0.487444566139123 no 1733 0.488461915910179 2483 688783 SGTC_2831 7999036 19.48 µM -0.0291740817377218 0.487342224597563 no 1734 0.488362876104827 2486 2988270 SGTC_2584 androsterone 48.74 µM -0.0292644136128161 0.487305001920135 no 1735 0.488326854280954 2455 2754130 A steroid. SGTC_1248 0469-0687 58.6 µM -0.0303218114302456 0.486869292740306 no 1736 0.487905200781599 2485 4017482 SGTC_1821 st053465 65.6 µM -0.0306383139674624 0.486738878376988 no 1737 0.487778993177386 2479 675086 SGTC_1885 st057546 99.9 µM -0.0310320484224646 0.486576642706748 no 1738 0.487621990514518 2563 702008 SGTC_2104 5389443 200 µM -0.0313362877929989 0.486451284412486 no 1739 0.487500675567562 2495 2244536 SGTC_512 prima-1 270 µM -0.0321170757911605 0.486129575954842 no 1740 0.487189342961358 2500 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1990 st072050 59.8 µM -0.0323461321776 0.486035199443984 no 1741 0.487098010138487 2458 17233948 SGTC_2342 7990637 118.86 µM -0.035927114093281 0.484559857401681 no 1742 0.485670237949717 2499 2033102 YER133W GLC7 SGTC_17 0960-0276 49.807 µM -0.0391450696341465 0.483234259654316 no 1743 0.484387364057397 2473 6821114 SGTC_1698 5-fluorocytosine 1.055 µM -0.0393861132445582 0.483134971941412 no 1744 0.48429127567247 2482 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_475 α-linolenic acid 10 µM -0.0402919555334186 0.482761857951954 no 1745 0.483930183563563 2525 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_862 0452-0056 10.2 µM -0.0412222981909399 0.482378668044467 no 1746 0.483559338696778 2490 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_606 k015-0008 38.6 µM -0.0417006615990645 0.482181645846087 no 1747 0.483368663270858 2507 1970475 SGTC_3180 9109287 49.47 µM -0.0429875459424535 0.481651642126405 no 1748 0.482855730787749 2538 18891271 SGTC_556 4058-0063 51.5 µM -0.0454099209435405 0.480654074941386 no 1749 0.481890286688403 2500 6615692 SGTC_1208 2323-2347 50.3 µM -0.0455308515624743 0.480604277180061 no 1750 0.481842092199708 2496 5412760 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.045717423991935 0.480527449511752 no 1751 0.481767737996073 2509 279621 SGTC_1442 4112-3290 3 µM -0.0459314027318834 0.480439337235287 no 1752 0.481682462410896 2476 704353 SGTC_393 acivicin 6.25 µM -0.0465689285729017 0.480176822196327 no 1753 0.481428398279204 2511 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_61 0978-8327 98.565 µM -0.0477828906068509 0.479676970967441 no 1754 0.480944636148743 2485 6150059 YHR072W ERG7 SGTC_439 amiodarone 34.4 µM -0.0482900377704973 0.479468161555243 no 1755 0.480742547000045 2582 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2043 5101342 149 µM -0.0489618824284725 0.479191549374262 no 1756 0.480474836450963 2513 678451 SGTC_95 0471-0001 561.058 µM -0.0491978020640042 0.479094418807726 no 1757 0.480380831423108 2499 4015405 SGTC_3345 9148410 3.559 µM -0.0494595577685405 0.478986652716113 no 1758 0.480276532978631 2508 4903596 SGTC_2391 6285546 200 µM -0.0513679739650693 0.478200995449381 no 1759 0.4795161520709 2496 846083 SGTC_1943 st076331 65.2 µM -0.0524476352935801 0.477756557517838 no 1760 0.479086009422347 2496 24208415 SGTC_1249 0481-0015 10.2 µM -0.052521679207022 0.477726078667372 no 1761 0.479056510831656 2500 4227577 SGTC_579 4491-1009 110 µM -0.0527311005494191 0.477639874829479 no 1762 0.478973079417129 2485 1271041 SGTC_485 niflumic acid 177 µM -0.0532425020450627 0.477429371694273 no 1763 0.478769345942476 2588 4488 A COX2 inhibitor. SGTC_2243 6634756 200 µM -0.0549717766070002 0.476717614518525 no 1764 0.478080474393536 2576 885676 SGTC_2639 lactacystin 53 µM -0.0558728026801266 0.47634678784845 no 1765 0.477721568645707 2535 3870 A proteasome inhibitor. SGTC_270 tamoxifen 5.46 µM -0.0565439450619808 0.476070585500614 no 1766 0.477454244202067 2503 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1184 1269-1718 139 µM -0.0576106178920897 0.475631630020199 no 1767 0.477029395933586 2560 5403821 SGTC_2688 kanamycin b 96.69 µM -0.0585331573872472 0.475252011886883 no 1768 0.47666197599249 2532 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2576 guaiol 23.12 µM -0.0586483804569595 0.475204600022692 no 1769 0.476616087470818 2598 227829 SGTC_1948 st076329 66.6 µM -0.0629974082248959 0.473415329501135 no 1770 0.474884284080205 2505 24208413 SGTC_963 1269-2853 151 µM -0.0632429863989067 0.473314309750904 no 1771 0.474786507536493 2549 3668223 SGTC_1002 4049-0206 172 µM -0.063394662536545 0.473251917906975 no 1772 0.474726118691438 2538 4662749 SGTC_3208 9114115 49.47 µM -0.0634865445820652 0.473214122628558 no 1773 0.474689536748662 2584 650895 SGTC_467 ro 31-8220 72.8 µM -0.0635096743374295 0.473204608342614 no 1774 0.474680327895133 2532 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_201 4262-0159 12.803 µM -0.0636555069574669 0.473144621322527 no 1775 0.474622266579458 2547 1341029 SGTC_2119 5528445 120.635 µM -0.0638326702235815 0.47307174752451 no 1776 0.474551732109499 2597 791935 SGTC_1876 myriocin 605 nM -0.0644506035272324 0.472817575792108 no 1777 0.474305718980383 2543 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2808 7946468 45.46 µM -0.0649302111060672 0.472620308582533 no 1778 0.474114783178015 2572 2970879 SGTC_1366 1683-0113 21.9 µM -0.0653998872618769 0.472427132770648 no 1779 0.473927806920647 2528 708623 SGTC_1012 4112-3522 18 µM -0.0658494839199686 0.4722422216459 no 1780 0.47374882961312 2521 3112398 SGTC_3110 9122132 49.47 µM -0.066146924330209 0.472119892970637 no 1781 0.473630426207602 2669 918317 SGTC_934 2950-0684 338 µM -0.0677609412307586 0.471456140448903 no 1782 0.472987968323763 2581 1121253 SGTC_2707 st078556 66.6 µM -0.0687051531898932 0.471067876894881 no 1783 0.472612158123511 2548 17250899 SGTC_520 3584-0023 682 µM -0.0692850529978707 0.470829433492015 no 1784 0.472381361562441 2616 1340790 SGTC_129 0088-0017 176.636 µM -0.0699074661217594 0.470573521087139 no 1785 0.472133655282388 2533 182446 SGTC_789 1309-1135 70.6 µM -0.0700946296815921 0.470496568981463 no 1786 0.47205917054195 2542 3092424 SGTC_446 go6976 132 µM -0.0705932815252095 0.470291554172927 no 1787 0.471860728820065 2538 3501 A protein kinase C inhibitor. SGTC_236 1509-0011 5.31 µM -0.0716715330454715 0.469848270806219 no 1788 0.471431655611212 2568 3107280 SGTC_469 w7 172 µM -0.0725192607355367 0.46949978502442 no 1789 0.471094338986692 2525 45115570 A P450 inhibitor. SGTC_2063 5246145 200 µM -0.0725407743902898 0.469490941446284 no 1790 0.471085778825649 2601 711240 SGTC_391 gliotoxin 8.33 µM -0.0729889777100456 0.469306702768968 no 1791 0.470907444314447 2632 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1425 4048-4433 7.33 µM -0.0759407632337948 0.468093506345722 no 1792 0.469733113052461 2547 23734946 SGTC_2138 5575593 77.673 µM -0.076953166217735 0.467677472072013 no 1793 0.469330401187402 2540 762213 SGTC_1936 st074407 74.3 µM -0.0781342413757149 0.467192168736881 no 1794 0.468860634881545 2547 809813 SGTC_2572 astragaloside iv 100 µM -0.0784501117329373 0.467062385961807 no 1795 0.468735006462131 2706 45006101 An anti-inflammatory agent. SGTC_3164 9100705 49.47 µM -0.0787231924944755 0.466950187121569 no 1796 0.46862639889174 2648 17174235 SGTC_256 clotrimazole 625 nM -0.0790637960136964 0.466810249345249 no 1797 0.468490939964975 2527 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_724 3910-0327 137 µM -0.0793589611228844 0.466688983366591 no 1798 0.468373554964628 2580 2885483 SGTC_1510 1123-0200 71.5 µM -0.0801458906277276 0.466365695470097 no 1799 0.468060612333593 2689 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1747 st037496 66.6 µM -0.0801897465406815 0.466347679150225 no 1800 0.468043172487702 2570 723305 SGTC_237 nikkomycin 200 µM -0.0802070440532285 0.466340573228435 no 1801 0.468036293934887 2567 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2923 7992654 58.14 µM -0.0807293931593092 0.466125994150759 no 1802 0.467828580370085 2569 2985126 SGTC_64 000l-0018 272.079 µM -0.081069802427316 0.465986160580136 no 1803 0.46769322039488 2566 6811119 SGTC_1428 4049-0204 61.7 µM -0.081848669418366 0.465666232844942 no 1804 0.467383526638603 2619 X1428 SGTC_959 1222-0044 107 µM -0.0828704156070035 0.46524657362592 no 1805 0.466977289014807 2568 6083612 SGTC_2221 6807166 181.081 µM -0.0829511605763674 0.465213411091309 no 1806 0.466945186960397 2564 674925 SGTC_1492 4158-0558 28.5 µM -0.0834204394018489 0.465020679721462 no 1807 0.466758618431001 2653 3967268 SGTC_2580 diallyl disulphide 81.36 µM -0.0844514703569507 0.464597267361669 no 1808 0.46634874299108 2597 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_3261 9137475 49.47 µM -0.0845021094834953 0.464576472475562 no 1809 0.466328612858375 2548 17027690 SGTC_832 4083-0019 164 µM -0.0861634176218975 0.463894312611699 no 1810 0.465668255514534 2658 1990758 SGTC_552 k242-0005 476 µM -0.087002518949712 0.463549804314127 no 1811 0.465334754934768 2654 4088318 SGTC_1914 st062367 72.6 µM -0.0873115710399633 0.463422924236184 no 1812 0.465211928393415 2595 978205 SGTC_2988 9073640 71.4286 µM -0.0883830464010104 0.462983063278458 no 1813 0.464786117785809 2658 9102229 SGTC_3082 9117008 49.47 µM -0.0894397415290435 0.46254931420717 no 1814 0.464366220419478 2612 41448529 SGTC_1010 4112-3296 15.2 µM -0.0898983195218872 0.462361092302332 no 1815 0.46418400828686 2571 704384 SGTC_440 fluspirilene 35.1 µM -0.0899975618109189 0.462320359722653 no 1816 0.464144576180191 2814 3396 An atypical antipsychotic. SGTC_1631 benzylvanillin 81.9 µM -0.0912544197688406 0.461804534664048 no 1817 0.463645217284157 2686 75506 SGTC_1203 3992-3522 103 µM -0.0917721673362615 0.461592065348114 no 1818 0.46343952898414 2706 5322312 SGTC_3304 9125678 46.087 µM -0.0918963885408814 0.461541090021433 no 1819 0.463390180424274 2598 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2940 9060638 45.86 µM -0.0920900383709889 0.461461625273038 no 1820 0.463313251524307 2641 4027022 SGTC_2797 7859098 81.82 µM -0.0930249665662903 0.461077996580243 no 1821 0.462941863384403 2597 972681 SGTC_2780 5215298 71.43 µM -0.0931148612861264 0.461041112020674 no 1822 0.462906155565988 2605 2834131 SGTC_567 1080-0542 68.4 µM -0.0932180524001959 0.460998772251923 no 1823 0.46286516654634 2569 5950415 SGTC_700 3453-2283 142 µM -0.0932509827712426 0.460985260868626 no 1824 0.46285208620433 2670 565664 SGTC_3052 9092717 49.47 µM -0.0940193172525354 0.460670024833723 no 1825 0.462546905878965 2698 25237534 SGTC_2540 epiandrosterone 100 µM -0.0942475450875426 0.46057639115174 no 1826 0.46245625865441 2581 441302 A steroid. SGTC_1913 st060213 96.1 µM -0.0950819273370149 0.460234092731142 no 1827 0.462124876464372 2633 688959 SGTC_2264 7948757 110.76 µM -0.095121817051061 0.460217729041759 no 1828 0.462109034573048 2567 2971411 SGTC_2115 tiliquinol 12.7705 µM -0.095741131144089 0.459963680643168 no 1829 0.461863086499158 2671 71208 A bioactive hydroxyquinoline. SGTC_365 0121-0052 13.6 µM -0.0957703597381735 0.459951691205221 no 1830 0.461851479313438 2642 3101739 SGTC_852 0418-0143 439 µM -0.0965130415456972 0.459647058713064 no 1831 0.461556558311615 2591 5369229 SGTC_1568 digitonin 820 nM -0.0965380743699635 0.459636791185557 no 1832 0.461546618075152 2605 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_153 4077-0274 519.67 µM -0.0973193654802311 0.459316348382549 no 1833 0.461236388783664 2600 3121976 SGTC_2158 5657123 3.6195 µM -0.0977585659194114 0.459136224019438 no 1834 0.461062004668584 2543 2858827 SGTC_1426 4048-4480 71.7 µM -0.0981645046064705 0.458969748385572 no 1835 0.46090083375775 2606 14224343 SGTC_2330 7979373 200 µM -0.0984720007523936 0.458843648868922 no 1836 0.460778752023038 2609 1863007 SGTC_2884 9058502 51.95 µM -0.0987665952306975 0.45872284401495 no 1837 0.460661795959252 2651 6471554 SGTC_3310 9130229 44.1445 µM -0.0987921657928603 0.45871235843109 no 1838 0.460651644427983 2715 7761258 SGTC_1621 st003705 32.4 µM -0.0991129787155675 0.458580806832781 no 1839 0.460524283652026 2596 24207032 SGTC_2242 6630449 61.2675 µM -0.0996621954028801 0.458355607200268 no 1840 0.460306257380674 2764 691249 YDR170C SEC7 SGTC_3342 9147791 14.508 µM -0.100589761068769 0.457975300551244 no 1841 0.45993806248112 2587 1838168 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.101253540452436 0.457703171217563 no 1842 0.459674597963854 2556 91467 include heat shock SGTC_304 1310-0298 97 µM -0.101355859802529 0.457661225160465 no 1843 0.459633987370575 2593 1550234 SGTC_327 1273-0057 3.96 µM -0.101383862523273 0.457649745461717 no 1844 0.459622873152267 2639 3108138 SGTC_1790 st045711 43.5 µM -0.102346947504845 0.457254950913389 no 1845 0.459240646102642 2595 585119 SGTC_1680 diphenhydramine 100 µM -0.10318050057213 0.456913289032779 no 1846 0.458909857795658 2660 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_276 colchicine 750 µM -0.103296971711041 0.456865551652966 no 1847 0.458863639494179 2701 2833 A microtubule depolymerizer. SGTC_886 0866-0150 153 µM -0.10436769734622 0.456426728526051 no 1848 0.458438778219117 2720 271463 SGTC_2912 7964298 10.93 µM -0.104640280589575 0.45631502225502 no 1849 0.458330625426958 2656 2975850 SGTC_2931 9014674 55.67 µM -0.106311292405643 0.455630307232936 no 1850 0.457667686161198 2613 2996810 SGTC_2005 4024620 188 µM -0.107544598801177 0.455125031103836 no 1851 0.457178472866605 2619 236743 SGTC_1005 4092-0690 4.4 µM -0.107695321751655 0.455063286033394 no 1852 0.457118690315881 2650 1529343 SGTC_2536 dehydroabietamide 32.04 µM -0.107815122783719 0.455014209191168 no 1853 0.457071173285897 2694 3983547 SGTC_2038 4100038 30.985 µM -0.107969192635274 0.454951095036462 no 1854 0.45701006501717 2685 3596803 SGTC_3101 9120531 49.47 µM -0.108224507543529 0.454846508716596 no 1855 0.456908802460256 2677 24824904 SGTC_2640 pentamidine 10.38 µM -0.108339190702212 0.454799531320649 no 1856 0.456863317934678 2661 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1515 3460-0031 42.1 µM -0.109942661048706 0.454142771991232 no 1857 0.456227424485818 2619 2876596 SGTC_1644 st010134 20.9 µM -0.110247288509997 0.454018014902228 no 1858 0.456106630004152 2622 3818134 SGTC_462 ag-879 158 µM -0.110381335292095 0.453963118838016 no 1859 0.456053477474326 2644 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1443 4112-3303 14 µM -0.111001244656052 0.453709259340243 no 1860 0.455807679870079 2605 704433 SGTC_1117 retinoic acid 1.10837 µM -0.112127950547458 0.453247909754104 no 1861 0.455360977917753 2650 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_223 busulfan 5 mM -0.112367526490885 0.45314981927459 no 1862 0.455266001165818 2704 2478 A DNA alkylator. SGTC_183 3914-0051 30.55 µM -0.112556643024851 0.453072390599405 no 1863 0.455191030192819 2667 1596232 SGTC_2654 protoveratrine a 100 µM -0.112729238109097 0.453001727744235 no 1864 0.455122610167666 2605 5702278 A heart drug and vasodilator. SGTC_801 0866-0028 10.1 µM -0.112765585454485 0.452986846819413 no 1865 0.45510820154751 2592 6849771 SGTC_3299 9121982 43.1275 µM -0.113284561456611 0.452774380663314 no 1866 0.454902478308503 2637 17594604 YPL160W CDC60 SGTC_3278 9139605 49.47 µM -0.114115199830925 0.452434349667305 no 1867 0.454573236606416 2821 7958859 SGTC_3095 9117207 49.47 µM -0.114320190998485 0.452350439624872 no 1868 0.454491988662339 2630 17015229 SGTC_1394 3474-0001 65.7 µM -0.116059419029686 0.451638598862767 no 1869 0.453802725166368 2675 5017666 YIL048W NEO1 SGTC_2979 9012552 45.46 µM -0.116262566241803 0.451555463756793 no 1870 0.453722226092787 2630 17100905 SGTC_2812 7970281 58.44 µM -0.117669772818353 0.450979643015263 no 1871 0.453164659073587 2721 2233435 SGTC_2563 tomatine 8.54 µM -0.11858435649082 0.450605455926834 no 1872 0.45280232980154 2588 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1925 st057770 10.1 µM -0.119269244515243 0.450325273817632 no 1873 0.452531024431692 2616 5989122 SGTC_316 k060-0003 58.6 µM -0.12111241552464 0.449571370922471 no 1874 0.451800997700572 2755 6152314 SGTC_535 2293-4129 48.2 µM -0.121295187988796 0.449496622301546 no 1875 0.451728615653603 2662 396118 YIL048W NEO1 SGTC_742 0kpi-0133 140 µM -0.121581841817841 0.449379392834715 no 1876 0.451615097459544 2747 2728852 SGTC_2156 5649887 115 µM -0.122205067168542 0.449124534904479 no 1877 0.45136830675788 2739 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2567 aureobasidin a 60 nM -0.124203938115466 0.448307271076925 no 1878 0.450576902110167 2879 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2526 patulin 37.61 µM -0.124542365675634 0.44816892227887 no 1879 0.450442929257334 2734 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2051 5263410 176 µM -0.125656638409063 0.447713453501757 no 1880 0.450001863626453 2613 227584 SGTC_2081 5214970 32.255 µM -0.125776425978357 0.447664493372583 no 1881 0.449954451451033 2651 2063512 SGTC_3033 9090887 49.47 µM -0.126006563514064 0.447570432733108 no 1882 0.449863364528622 2643 19325384 SGTC_1274 0865-0114 173 µM -0.126825679300897 0.447235671866417 no 1883 0.449539185353967 2687 870624 SGTC_1801 st050089 28.441 µM -0.126856129920228 0.447223227858459 no 1884 0.449527134645014 2620 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2788 5282734 71.43 µM -0.127342388366259 0.447024519605372 no 1885 0.449334706153747 2742 743706 SGTC_2345 9052315 157.45 µM -0.128187611443915 0.446679153062323 no 1886 0.449000251910188 2732 6469265 SGTC_2237 6667747 47.222 µM -0.128333565770017 0.446619518762388 no 1887 0.448942501536829 2682 729940 YDL015C TSC13 SGTC_1132 3456-3614 2.5 µM -0.128867415507529 0.446401407699994 no 1888 0.448731280147707 2882 3125502 SGTC_3100 9120536 49.47 µM -0.129497480680064 0.4461440074715 no 1889 0.448482009147075 2594 16421196 SGTC_3169 9102970 49.47 µM -0.130222934419572 0.445847666310345 no 1890 0.448195025017904 2619 17027839 SGTC_1253 0550-0034 176 µM -0.131038935039322 0.445514373739105 no 1891 0.447872253617674 2723 5969915 SGTC_2683 piperine 63.03 µM -0.131515359753002 0.445319797535134 no 1892 0.447683818390611 2642 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1202 1988-0068 29.6 µM -0.133726394261213 0.444416963990137 no 1893 0.446809466507904 2652 2850480 SGTC_406 estrone 100 µM -0.134093490826339 0.444267094929821 no 1894 0.446664323363447 2726 5870 A steroid. SGTC_2483 5729050 27.16 µM -0.13418089653893 0.444231412271954 no 1895 0.446629765825028 2697 2865180 SGTC_2680 butyl paraben 22.24 µM -0.13494555316298 0.443919266848276 no 1896 0.446327461355201 2626 7184 An antifungal and steroid mimetic. SGTC_2381 9035592 200 µM -0.135398417640656 0.443734416502091 no 1897 0.446148437576301 2686 4749657 SGTC_350 k064-0020 19.8 µM -0.135622630717111 0.443642901675512 no 1898 0.446059807013782 2774 2790705 SGTC_1961 st076550 68.7 µM -0.135852030049922 0.443549273136726 no 1899 0.445969129133506 2761 1579337 SGTC_2172 5754775 163.918 µM -0.136403035723409 0.443324394974856 no 1900 0.4457513369748 2662 2263357 SGTC_2249 haloperidol 116.36 µM -0.136792204522954 0.44316557717901 no 1901 0.445597522804536 2633 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_123 0083-0120 66.675 µM -0.137901363576426 0.442712985222221 no 1902 0.445159186363976 2649 16001701 SGTC_1647 st011722 22.4 µM -0.138097898395991 0.442632797038052 no 1903 0.445081523350224 2772 2854783 SGTC_1378 2093-0007 380 nM -0.138253013348696 0.442569510235552 no 1904 0.445020229365484 2739 3618014 SGTC_3260 9137109 49.47 µM -0.139591393174648 0.442023513154978 no 1905 0.444491420644398 2709 17478346 SGTC_2368 9071271 200 µM -0.143947257054264 0.440247289863001 no 1906 0.442771059258234 2687 27209959 SGTC_1135 dihydrocapsaicin 536.708 nM -0.144029474910313 0.440213774715294 no 1907 0.442738597340278 2635 107982 A Capsaicinoid. SGTC_3238 9133470 49.47 µM -0.146600109128367 0.439166103007515 no 1908 0.441723833770891 2789 3534688 SGTC_2946 9065502 71.43 µM -0.146730633604106 0.439112918565875 no 1909 0.441672319088435 2645 16489101 SGTC_2467 5474540 200 µM -0.147256599923088 0.438898615695013 no 1910 0.441464743600215 2665 5413519 SGTC_1545 lovastatin 49.4 µM -0.148690966438327 0.438314280002063 no 1911 0.440898744866684 2713 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2016 5121758 140 µM -0.149017857186453 0.438181129227206 no 1912 0.44076977114755 2644 2795203 SGTC_2802 7925815 54.55 µM -0.149282811391838 0.438073211888792 no 1913 0.440665238906145 2683 1262923 SGTC_1234 0326-0494 15.5 µM -0.149473919862333 0.437995375191991 no 1914 0.440589843549327 2797 1547813 SGTC_1016 4226-1401 38 µM -0.150512594655982 0.437572374666353 no 1915 0.440180107415299 2641 2901613 SGTC_891 0929-0073 133 µM -0.15297671974977 0.436569145443301 no 1916 0.439208317066095 2823 5603632 SGTC_656 4090-1979 187 µM -0.153319445621242 0.436429642234763 no 1917 0.439073183291126 2742 22330961 SGTC_3296 9122258 64.045 µM -0.153638194026003 0.436299905915019 no 1918 0.438947509991396 2776 4730474 SGTC_280 3448-3607 3.04 µM -0.155096614333247 0.435706390298576 no 1919 0.438372575630025 2705 626179 SGTC_2744 captopril 92.04 µM -0.155190449468896 0.435668208295 no 1920 0.438335588645726 2738 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_763 3453-1109 128 µM -0.156068446772038 0.435310975739579 no 1921 0.437989534693244 2669 1560353 SGTC_2314 7727897 200 µM -0.156671321986366 0.435065713219935 no 1922 0.43775194483188 2711 900724 SGTC_1877 wortmannin 25 µM -0.156741928248691 0.435036990716046 no 1923 0.437724120752085 2770 312145 A covalent inhibitor of PI 3-kinase. SGTC_3084 9116877 49.47 µM -0.156982613417316 0.434939082987659 no 1924 0.437629275342024 2668 27241325 SGTC_359 0081-0058 15.9 µM -0.157880643506661 0.434573810790897 no 1925 0.437275425499314 3050 3494159 SGTC_550 4123-0385 25.7 µM -0.158072474668851 0.434495791022896 no 1926 0.437199844963274 2696 5731123 SGTC_1583 clindamycin 39.6 µM -0.159800950883234 0.43379291682447 no 1927 0.436518937505977 2687 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1620 st003704 16.5 µM -0.160266349217485 0.433603701132838 no 1928 0.436335632815222 2704 2834414 SGTC_3184 9108758 49.47 µM -0.162077931120364 0.432867316652642 no 1929 0.435622242407997 2664 902885 SGTC_2167 5876490 200 µM -0.162796003640921 0.432575493870891 no 1930 0.435339527462808 2938 686534 SGTC_187 1488-2104 32.728 µM -0.162907777769528 0.432530072462862 no 1931 0.435295523432692 2764 2852859 SGTC_3040 9091894 49.47 µM -0.163363248399043 0.43234499308504 no 1932 0.435116218821948 2714 25236966 SGTC_2450 5739737 12.93 µM -0.16410582776062 0.432043279622769 no 1933 0.434823917061688 2785 2262825 SGTC_1782 st039423 80.636 µM -0.165947407856119 0.431295208405934 no 1934 0.434099169309218 2752 2068169 SGTC_800 3448-7362 155 µM -0.167739251930006 0.430567576990035 no 1935 0.433394207545286 2761 15991913 SGTC_25 0118-0223 35.662 µM -0.167779932324811 0.43055106023617 no 1936 0.433378205187026 2794 5333628 SGTC_1727 st034309 9.9045 µM -0.16805535279522 0.430439239245288 no 1937 0.433269866510996 3009 870305 SGTC_286 k060-0067 22.9 µM -0.168878455326544 0.430105092058617 no 1938 0.432946122968837 2724 5985051 SGTC_1140 3229-1848 2.98 µM -0.1689905988443 0.430059570079232 no 1939 0.432902018042321 2806 2849525 SGTC_1251 0490-5699 265 µM -0.169367489213446 0.429906587262198 no 1940 0.43275379694887 2775 3883818 SGTC_2472 5377652 49.4 µM -0.169542747536508 0.42983545208931 no 1941 0.432684875670212 2747 1610903 SGTC_1742 st038235 28.8875 µM -0.170517223111226 0.429439966181064 no 1942 0.432301695313104 2840 564103 YBR002C RER2 SGTC_2148 5546263 113.568 µM -0.172659167040927 0.428570918645211 no 1943 0.431459670821723 2706 792097 SGTC_1347 1493-0251 600 nM -0.173514177962945 0.428224112863981 no 1944 0.431123642253005 2841 3986378 SGTC_1895 st058434 18.3 µM -0.174183417121725 0.427952697669455 no 1945 0.430860658769537 2881 5393175 SGTC_1997 st073024 93.8 µM -0.174717691730764 0.427736042868265 no 1946 0.430650732806159 2721 686268 SGTC_184 1494-0393 24.714 µM -0.175768715033712 0.427309903881617 no 1947 0.430237824365603 2698 3090647 SGTC_420 mitomycin C 81.9 mM -0.175872510986886 0.427267824248332 no 1948 0.430197050880078 2717 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2520 obtusaquinone 4.71 µM -0.17738938941246 0.426652965370941 no 1949 0.429601270587541 2889 5967872 SGTC_2829 7992743 58.44 µM -0.177940456820574 0.426429637077127 no 1950 0.429384868935416 2905 16462845 SGTC_856 0433-0016 11.3 µM -0.178742556457257 0.426104616396146 no 1951 0.429069926011099 2792 3911780 SGTC_2635 hydroquinidine 100 µM -0.180043643829283 0.425577506547524 no 1952 0.428559152589359 2722 442912 An experimental heart treatment. SGTC_1061 3448-9325 110 µM -0.180054606451409 0.425573065821343 no 1953 0.428554849453093 2672 723482 SGTC_298 1391-0729 10 µM -0.180698211227667 0.425312371715022 no 1954 0.428302231454197 2737 3237558 SGTC_2435 5706476 10.6 µM -0.181505591186868 0.424985386148552 no 1955 0.427985372454846 2855 5725375 SGTC_2715 st079500 56.4 µM -0.182078470176444 0.424753403795652 no 1956 0.427760572303943 2702 28246688 SGTC_1409 3909-8004 61.9 µM -0.182300078411205 0.424663672458274 no 1957 0.42767361857607 2771 2119279 SGTC_3324 9138759 60.749 µM -0.182632758048187 0.42452897455659 no 1958 0.427543089704385 2856 45595710 SGTC_1112 tnp00069 1.16933 µM -0.183022651555338 0.424371122679319 no 1959 0.427390122718573 2849 145826 SGTC_2594 a-mangostin 100 µM -0.185004217777162 0.423569055854505 no 1960 0.426612863687002 2891 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_3339 9145883 14.936 µM -0.185293449450746 0.423452011660277 no 1961 0.426499437825166 2861 2030670 SGTC_2174 5790901 200 µM -0.186245090943921 0.423066955947788 no 1962 0.426126282520063 2819 786020 SGTC_2296 7971656 126.45 µM -0.186374287489833 0.423014685754581 no 1963 0.426075627381773 2799 666570 SGTC_151 3013-0144 2.285 µM -0.187248371764494 0.422661085366436 no 1964 0.425732950147998 2977 906558 YHR107C CDC12 SGTC_1882 5615643 20 µM -0.187548118962083 0.422539840538959 no 1965 0.42561544973403 2697 2253075 SGTC_1831 st055328 12 µM -0.189780248432683 0.421637197419034 no 1966 0.424740667038245 2886 1103068 SGTC_653 0203-0016 55.2 µM -0.191163078006061 0.421078205915517 no 1967 0.424198914807987 2803 295302 SGTC_1956 st077085 54 µM -0.191251334419811 0.421042534755586 no 1968 0.424164343373824 2788 24208685 SGTC_1352 1496-0991 99 µM -0.191771121928582 0.420832462068805 no 1969 0.42396074622683 2735 3000039 SGTC_2288 7946289 167.31 µM -0.192526700421404 0.420527134412616 no 1970 0.423664827598167 2909 1246052 SGTC_3157 9099274 49.47 µM -0.192682556309391 0.420464159322907 no 1971 0.423603792750168 2802 17217662 SGTC_827 3253-0474 693 µM -0.194036781926581 0.419917057131367 no 1972 0.423073540688187 2842 5402065 SGTC_794 k038-0031 316 µM -0.194273344694165 0.419821502484776 no 1973 0.422980927926716 2742 6624242 SGTC_2090 5301565 104.445 µM -0.194285923947802 0.419816421487252 no 1974 0.422976003351114 2776 2056344 SGTC_1524 corynanthine 62.1 µM -0.195191199015834 0.419450798977323 no 1975 0.422621634359174 2945 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_3323 9138564 53.9225 µM -0.195413565024722 0.419361000415341 no 1976 0.422534598982229 2895 43912313 YNL103W MET4 SGTC_3163 9099914 49.47 µM -0.19603389106241 0.419110514980375 no 1977 0.422291819689663 2834 16268368 SGTC_2677 mitomycin C 100 µM -0.198299933387686 0.418195774542716 no 1978 0.421405201901602 2772 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1739 st037196 92.5 µM -0.19837457458812 0.418165651391851 no 1979 0.421376004337845 2890 612214 SGTC_1660 st012960 28.1 µM -0.19993288141501 0.417536871177727 no 1980 0.420766536969329 2846 24207266 SGTC_2883 9059145 45.46 µM -0.200110597023877 0.417465175901379 no 1981 0.420697042881131 2718 16476510 SGTC_1701 st028638 40.4 µM -0.200724165440891 0.417217666934426 no 1982 0.420457131486653 2866 3490878 SGTC_2126 5251174 33.877 µM -0.201863530738628 0.416758142468954 no 1983 0.420011706684574 2892 790722 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.20186893272187 0.416755964032049 no 1984 0.420009595070472 2726 6708630 An antioxidant. SGTC_3155 9099265 49.47 µM -0.202002167142615 0.416702235911288 no 1985 0.419957514985907 2871 25236499 SGTC_1419 3993-2473 62.6 µM -0.203746848759392 0.415998819449544 no 1986 0.419275664997284 2788 704026 SGTC_2936 9038235 15.59 µM -0.204010668733209 0.415892476518058 no 1987 0.419172580899023 2746 4749415 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.204314975474304 0.415769821464623 no 1988 0.4190536840332 2754 3256 An antibiotic and ribosome inhibitor. SGTC_2218 6965428 192.983 µM -0.204909400982239 0.415530253695921 no 1989 0.418821455072367 2757 675684 SGTC_2512 diallyl trisulfide 49.23 µM -0.206290400712837 0.414973798947585 no 1990 0.418282038200372 2752 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_354 2783-3500 4.88 µM -0.20670020530114 0.414808706616164 no 1991 0.41812199852794 2796 6740761 SGTC_2878 9043973 25.97 µM -0.208163329456831 0.414219400877728 no 1992 0.417550720118197 2942 6465167 SGTC_1707 st032323 6.317 µM -0.209010699932831 0.413878191806171 no 1993 0.417219942876263 2780 3132057 YMR211W DML1 SGTC_2499 avocadenofuran 51.48 µM -0.210406213228035 0.413316404897343 no 1994 0.41667532187024 2764 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_32 0928-0142 34.1 µM -0.210977337455502 0.413086540513675 no 1995 0.416452477711162 2794 2244242 SGTC_967 1306-0166 352 µM -0.211168672840288 0.413009539074568 no 1996 0.416377827497359 2905 4437607 SGTC_1792 st045773 43.6 µM -0.211489153664857 0.412880571555284 no 1997 0.416252797466821 2768 2919270 SGTC_565 1418-0001 44.5 µM -0.211535921469702 0.412861752095707 no 1998 0.41623455252784 2951 2862145 SGTC_1421 4029-0249 71.4 µM -0.212299158410421 0.412554652336056 no 1999 0.41593682597923 2939 2894095 SGTC_1160 4092-0570 10.5 µM -0.212762336140045 0.41236831195629 no 2000 0.415756171248467 2779 4994975 SGTC_2289 7946404 165.07 µM -0.214002048315895 0.411869662389695 no 2001 0.415272729929135 2794 1246120 YPR165W RHO1 SGTC_1183 1254-0324 198 µM -0.214288501697721 0.411754462420911 no 2002 0.415161042051856 2917 5799357 SGTC_205 1486-1330 71.903 µM -0.214802510118256 0.411547768090345 no 2003 0.414960647893889 2769 4118834 SGTC_2851 9015922 71.43 µM -0.215177333257935 0.411397058759101 no 2004 0.414814531223448 2979 2996893 SGTC_2278 7948257 134.34 µM -0.217827788142549 0.410331735028046 no 2005 0.413781646295184 2945 1247028 SGTC_3242 9133940 49.47 µM -0.218673562120409 0.409991923482147 no 2006 0.413452172468263 2936 17248444 SGTC_2003 4023581 200 µM -0.221195918521648 0.40897890391705 no 2007 0.412469943552493 2929 16641307 SGTC_2820 7989630 71.43 µM -0.221844244630344 0.408718623450683 no 2008 0.412217567637843 2849 2984098 SGTC_2747 doxorubicin 7.63 µM -0.223317521876896 0.408127303530142 no 2009 0.411644195550093 2785 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1717 st033143 58.0435 µM -0.226884399702908 0.406696557181733 no 2010 0.410256816492868 2964 674616 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.227247434768282 0.406551005986165 no 2011 0.410115672382944 2788 4620898 SGTC_1236 0330-0013 258 µM -0.22800686787576 0.406246569190828 no 2012 0.409820450674611 2866 4617066 SGTC_833 3852-0053 558 µM -0.228822911509888 0.405919501890966 no 2013 0.409503279190704 2973 3123681 SGTC_2671 danthron 100 µM -0.229197035051295 0.405769576482044 no 2014 0.409357888469876 2859 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2188 6126565 140.678 µM -0.230141518558693 0.405391147863828 no 2015 0.408990901747608 2915 874518 SGTC_1552 6-methylflavone 10.6 µM -0.231926487414961 0.404676201570523 no 2016 0.408297555692584 2826 689013 SGTC_235 0330-0087 5 mM -0.232144999699582 0.404588701096816 no 2017 0.408212697341612 2835 46494818 YHR062C RPP1 SGTC_2096 5468907 200 µM -0.233122361712213 0.404197387329833 no 2018 0.407833195544311 2964 759785 SGTC_1114 scopoletin 1.73284 µM -0.233508002103292 0.40404301193649 no 2019 0.407683478254706 2950 5280460 A coumarin with genotoxic properties. SGTC_1513 0337-0559 19 µM -0.233863220070556 0.403900828139699 no 2020 0.407545583799834 2841 775073 SGTC_460 trequinsin 123 µM -0.234196754355133 0.403767335270465 no 2021 0.407416117306704 2894 5537 A vasodilator. SGTC_3074 9116018 49.47 µM -0.234283537416861 0.403732603287132 no 2022 0.407382432775921 2786 17027303 SGTC_1633 st005664 67.9 µM -0.234404519647641 0.403684185510616 no 2023 0.407335475104581 2792 2063822 SGTC_2412 st077135 33.4 µM -0.234923457189344 0.403476520508363 no 2024 0.407134071395854 3097 13258915 SGTC_854 0422-0053 192 µM -0.236385343236371 0.402891659079064 no 2025 0.406566834184403 2839 3596728 SGTC_523 1934-0222 13.7 µM -0.236941994371752 0.402669014908908 no 2026 0.406350895321742 2827 1361595 SGTC_1835 st008666 49.2 µM -0.237830163200565 0.402313838741844 no 2027 0.406006411472356 2843 690455 SGTC_2129 girgensonine 121.053 µM -0.23899169153208 0.401849468611328 no 2028 0.405556012645242 2902 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2899 9053889 58.44 µM -0.239256424883367 0.40174364960726 no 2029 0.405453376064742 2902 6470052 SGTC_1952 st077036 64.1 µM -0.240642154793979 0.401189864463164 no 2030 0.404916237631335 2806 2937007 SGTC_641 4092-0595 30 µM -0.240678938782321 0.401175167020246 no 2031 0.404901981809566 2891 786260 SGTC_582 0987-0078 156 µM -0.243267193923654 0.4001413537704 no 2032 0.403899208290795 2875 1625765 SGTC_3181 9108277 49.47 µM -0.243551909047215 0.400027674062121 no 2033 0.403788938889682 2856 17097298 SGTC_2972 9093619 59.92 µM -0.244332069696014 0.399716218643417 no 2034 0.403486823975864 2832 25236256 SGTC_23 0213-0011 39.996 µM -0.245053046043217 0.39942844747232 no 2035 0.403207679200961 3003 627608 SGTC_681 1642-0006 26.6 µM -0.245892793291328 0.399093338856728 no 2036 0.402882611356253 2878 4446530 SGTC_2779 methotrexate 400 µM -0.246250036991767 0.398950800106843 no 2037 0.402744341939903 2918 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_3320 9137005 35.139 µM -0.247293556583449 0.398534517361344 no 2038 0.4023405225329 2887 4908713 SGTC_2071 5230951 39.92 µM -0.250132053762467 0.397402764154584 no 2039 0.401242614180415 2897 1799272 SGTC_1115 galangin 695.678 nM -0.250777576935533 0.397145504104049 no 2040 0.400993039359839 2920 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_407 eburnamonine 100 µM -0.253043307339539 0.396242898458938 no 2041 0.400117373752611 2826 3195 SGTC_112 phenothiazine 287.218 µM -0.253262568447535 0.396155580194082 no 2042 0.400032659695322 2903 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_346 4513-0042 7.16 µM -0.253657786740215 0.395998202124524 no 2043 0.399879974434801 2855 2827372 SGTC_772 k072-0172 35.3 µM -0.253974352331778 0.395872156212303 no 2044 0.399757686226147 2880 5861980 SGTC_1053 3366-3204 134 µM -0.254938376482648 0.395488380903631 no 2045 0.39938534758831 2910 3632071 YPR165W RHO1 SGTC_2137 5261020 140 µM -0.255451808098 0.395284026547518 no 2046 0.399187080305045 2843 763655 SGTC_571 k831-0106 44.2 µM -0.256276015201747 0.394956038591277 no 2047 0.398868858032931 2921 4783639 SGTC_1009 4106-0057 9.87 µM -0.256827726676213 0.394736530099075 no 2048 0.398655882510243 2918 2928005 SGTC_663 1486-0733 13.9 µM -0.256829361582323 0.394735879671423 no 2049 0.398655251437162 2859 722445 YPR165W RHO1 SGTC_1181 1222-0449 220 µM -0.257650139003985 0.394409380371202 no 2050 0.398338465185226 3042 658318 SGTC_3121 9125696 49.47 µM -0.259404728949584 0.393711666248126 no 2051 0.39766149069648 2870 1235365 SGTC_479 n-linoleoylglycine 10 µM -0.26156205820838 0.392854270209512 no 2052 0.396829549493986 2874 6433346 An anti-infammatory. SGTC_1979 st071809 45.3 µM -0.262459973142422 0.392497561168085 no 2053 0.396483420373888 3001 4976333 SGTC_2738 aclarubicin 5.55 µM -0.262548981919326 0.392462206122927 no 2054 0.3964491136232 2943 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_992 3909-8734 162 µM -0.262704308647312 0.392400511148 no 2055 0.396389247792139 2912 4288319 SGTC_1272 0839-0021 27 µM -0.262724683899458 0.392392418403572 no 2056 0.396381394969431 2955 5027250 SGTC_2948 9070189 9.45 µM -0.26407120702135 0.39185770293869 no 2057 0.3958625250361 3025 6473636 YDL196W YDL196W SGTC_134 0269-0018 6.916 µM -0.266007036149427 0.391089327226846 no 2058 0.395116895066916 2942 4378915 SGTC_2274 7947094 46.08 µM -0.266015311504865 0.391086043455342 no 2059 0.3951137084419 2875 2971028 SGTC_4 0960-0234 25.671 µM -0.266216377572044 0.391006260142586 no 2060 0.395036285264114 2947 6821112 SGTC_2062 5245942 200 µM -0.267289712875142 0.390580436783555 no 2061 0.394623053332252 2856 1376160 SGTC_2035 5154463 94.595 µM -0.267432858854419 0.390523656511275 no 2062 0.39456795136708 3009 2769623 SGTC_1663 st014140 55.4 µM -0.267558394605124 0.390473863432237 no 2063 0.39451962993961 2916 4207120 SGTC_1501 4491-0275 38.4 µM -0.267668694249676 0.390430115155089 no 2064 0.394477174558617 2935 5104718 SGTC_583 1488-1091 88.9 µM -0.267775203821033 0.390387871455683 no 2065 0.394436179202356 2948 4303273 SGTC_875 0709-0210 25.7 µM -0.267798043992891 0.390378812782394 no 2066 0.394427388210557 2956 6251364 SGTC_2131 toluylene red 5.2905 µM -0.267959308338347 0.390314855192991 no 2067 0.394365320438297 2913 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2495 cafestol 54.53 µM -0.267972673330218 0.39030955475796 no 2068 0.394360176611467 3083 16667697 An anti-infammatory. SGTC_2442 5158906 48.48 µM -0.268648413959492 0.390041588725897 no 2069 0.39410012620243 3020 1893835 SGTC_3072 9116419 49.47 µM -0.269401742939096 0.389742916499061 no 2070 0.393810272528571 2945 17170162 SGTC_947 3447-0010 211 µM -0.269542541223314 0.389687101439711 no 2071 0.393756104973946 2856 748350 SGTC_2531 methyl deoxycholate 70.07 µM -0.269863175530337 0.389560004526267 no 2072 0.393632759038608 2869 16667744 Haematoxylin. SGTC_2861 9024595 19.48 µM -0.270366940453702 0.389360339940028 no 2073 0.393438985505495 2925 16482810 SGTC_1571 st070080 73.4 µM -0.270643405360297 0.389250776932379 no 2074 0.393332654296866 3029 4315245 SGTC_87 0100-0052 35.5 µM -0.271590885584016 0.388875357479628 no 2075 0.392968304187775 2966 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1027 k015-0025 8.67 µM -0.272341062612341 0.388578188907007 no 2076 0.392679892792698 2868 3598955 SGTC_3079 9117512 49.47 µM -0.27358743569091 0.388084605789877 no 2077 0.392200845300197 2874 7185044 SGTC_1051 3253-3903 78 µM -0.274471183756467 0.387734737270727 no 2078 0.391861272813722 2835 5509239 SGTC_2160 5660466 132.927 µM -0.274484615141832 0.387729420599142 no 2079 0.391856112555776 2909 2859134 SGTC_3268 9137683 49.47 µM -0.275039136320662 0.387509937651067 no 2080 0.391643085450741 2865 1953228 SGTC_1283 0922-0125 16.4 µM -0.275260292420397 0.387422412707668 no 2081 0.391558134285223 3001 3360884 SGTC_1712 st032288 53.4 µM -0.275772296318908 0.38721980353318 no 2082 0.391361481614131 2984 2883011 SGTC_3251 9135047 49.47 µM -0.276308765126946 0.387007546109796 no 2083 0.391155462142032 2987 17682963 SGTC_995 3931-2021 34.6 µM -0.277097446231861 0.386695560587872 no 2084 0.390852641345069 2991 730143 SGTC_986 1493-0483 84 µM -0.277111408077675 0.386690038236629 no 2085 0.390847281171562 2992 40079 SGTC_1073 triclabendazole 3.09 µM -0.278174217370517 0.386269731000861 no 2086 0.390439312814485 2971 50248 An antihelmetic and likely tubulin inhibitor. SGTC_952 1185-0122 232 µM -0.279053271391643 0.385922193913912 no 2087 0.390101971580741 2844 678600 SGTC_1031 k035-0009 16 µM -0.280634969821742 0.385297094594443 no 2088 0.38949519569343 3087 5180959 SGTC_329 k048-0121 21.3 µM -0.284434485082793 0.383796717207529 no 2089 0.388038717285173 2982 6832902 SGTC_2283 7944793 200 µM -0.287462813609339 0.382602116128862 no 2090 0.386878985652974 2993 2970533 SGTC_1136 pergolide 1.05886 µM -0.287824671222639 0.382459446639856 no 2091 0.386740475614696 2911 47811 A dopamine receptor agonist. SGTC_3017 9080681 49.47 µM -0.288335640404587 0.382258014150628 no 2092 0.386544913970008 2980 16451914 SGTC_1124 fisetin 1.16336 µM -0.289122330791573 0.381947950113061 no 2093 0.386243882746655 2975 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_916 4466-0038 42 nM -0.289845552953299 0.381662968058121 no 2094 0.385967198369713 3107 5722064 YGL116W CDC20 SGTC_3354 9151612 71.43 µM -0.29200730870734 0.380811521967931 no 2095 0.385140517927707 3046 27261949 SGTC_1200 1643-0193 18.4 µM -0.294052668156083 0.380006451641015 no 2096 0.384358829021708 3013 5403974 SGTC_3099 9120367 49.47 µM -0.294351691062162 0.379888797221746 no 2097 0.384244588715205 2910 24824940 SGTC_1559 coumarin 343 70.1 µM -0.294771798184932 0.379723519437964 no 2098 0.384084105736967 3075 108770 A hepatotoxic, DNA x-linker. SGTC_1482 3346-2049 8.48 µM -0.296558848213787 0.379020707295241 no 2099 0.383401666246508 3020 3826804 SGTC_607 4491-0986 66.8 µM -0.297225629048043 0.378758577594542 no 2100 0.383147128190611 3073 698981 YDR232W HEM1 SGTC_1408 3909-7976 48.8 µM -0.297543074532565 0.378633800717109 no 2101 0.38302596372557 2968 24152374 SGTC_1072 oxiconazole 14.9 nM -0.297892809646845 0.378496346546091 no 2102 0.382892488013765 2929 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_768 0384-0033 77.3 µM -0.297997480180304 0.378455211538929 no 2103 0.382852543415443 2950 3965305 YMR134W ERG29 SGTC_3225 9130819 49.47 µM -0.298043653687893 0.378437066014283 no 2104 0.382834922976314 3060 4547121 SGTC_173 1273-0061 2.693 µM -0.298739168749929 0.378163771044376 no 2105 0.382569534314774 3031 2847414 YPL266W DIM1 SGTC_599 1935-0052 86.5 µM -0.299280152458887 0.377951239597905 no 2106 0.382363148514795 2928 9557311 SGTC_2335 9018011 154.17 µM -0.29988340255128 0.377714289669687 no 2107 0.382133047434954 3027 6458208 SGTC_2484 5809818 12.04 µM -0.300384085701609 0.377517661831319 no 2108 0.381942100647092 2958 2870548 SGTC_3302 9125395 16.351 µM -0.30140888397428 0.377115302992894 no 2109 0.381551360347162 2983 17599668 SGTC_1188 1403-0014 4.57 µM -0.301963109174584 0.376897757267257 no 2110 0.381340092797568 2954 9614867 SGTC_1769 st044406 64.4 µM -0.302819227135599 0.376561788736861 no 2111 0.381013814920698 2935 670903 SGTC_2698 st077697 67.5 µM -0.303074591013637 0.376461593734937 no 2112 0.380916508736019 2973 3154499 SGTC_428 3448-4153 16.5 µM -0.303107331040955 0.376448748404411 no 2113 0.380904033721471 2872 3834874 SGTC_1449 4112-4002 201 µM -0.303335407635845 0.376359267876647 no 2114 0.380817132561507 2968 2059539 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.303350328370186 0.376353414306348 no 2115 0.380811447710998 2991 1377 SGTC_1638 st008370 60.6 µM -0.304120116047259 0.376051456634085 no 2116 0.38051819092306 2913 24207134 SGTC_2915 7971052 15.16 µM -0.305622601997407 0.375462308718738 no 2117 0.37994600474526 2997 5741558 SGTC_842 0271-0008 11.1 µM -0.305781011654037 0.37540021074342 no 2118 0.379885693467753 3066 1221709 SGTC_2065 5221596 34.26 µM -0.306492874692701 0.375121194058886 no 2119 0.379614702073418 3073 788581 SGTC_2826 7992541 19.48 µM -0.306866657254146 0.374974715100443 no 2120 0.379472434519977 2906 2985066 SGTC_2407 paclitaxel 400 µM -0.307441344312951 0.374749540304898 no 2121 0.379253731374253 3163 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1604 st002052 72.4 µM -0.309794957552763 0.373827790091573 no 2122 0.378358443197542 3080 6254834 YHR062C RPP1 SGTC_1873 rapamycin 2 nM -0.30999658495127 0.37374885981472 no 2123 0.378281776670198 2962 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_395 anisomycin 6.25 µM -0.310550892013891 0.373531894725516 no 2124 0.378071032410991 3003 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3070 9117005 49.47 µM -0.314307257344704 0.372062649613402 no 2125 0.376643843382405 3000 8779016 SGTC_516 3992-2719 87.3 µM -0.314682771086173 0.371915875089679 no 2126 0.376501263421688 2890 5350887 YDR037W KRS1 SGTC_3224 9130643 49.47 µM -0.31535711659463 0.371652344943095 no 2127 0.376245261418191 3148 17644395 SGTC_2996 9066192 71.4286 µM -0.317248372910598 0.370913574604144 no 2128 0.375527573927783 3013 6472854 SGTC_29 0299-0004 12.984 µM -0.319411294808557 0.370069268161514 no 2129 0.374707323521499 3006 16871 A napthoquinone isolated from Swertia calycina. SGTC_1787 fluconazole 80 µM -0.319962854963243 0.369854064108698 no 2130 0.374498244463178 3053 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2945 9067681 61.76 µM -0.319964561469615 0.369853398338657 no 2131 0.374497597637659 2950 16456930 SGTC_289 k017-0060 526 µM -0.320681163149319 0.369573860525339 no 2132 0.374226011805925 2985 5512909 SGTC_2845 9003024 42.97 µM -0.322644218596291 0.368808449300806 no 2133 0.373482350780958 3196 2990173 SGTC_711 k292-0785 179 µM -0.323525944788486 0.368464826186804 no 2134 0.373148481006238 2943 4146315 SGTC_342 k048-0088 23.3 µM -0.324310606085565 0.368159119276813 no 2135 0.37285144538298 2939 6820570 SGTC_2344 7990960 76.95 µM -0.32438558482133 0.368129911653109 no 2136 0.372823065936341 2993 140813 SGTC_1597 7-benzyloxygramine 47.5 µM -0.325234437185342 0.367799298295949 no 2137 0.372501823546883 2979 260807 SGTC_2687 chenodiol 100 µM -0.326947319736788 0.36713245847199 no 2138 0.371853865041154 3081 5702181 A cholesterol synthesis inhibitor. SGTC_1417 3966-0327 90.4 µM -0.329010317825497 0.366329847598156 no 2139 0.3710739446574 3035 651118 SGTC_743 1275-0778 158 µM -0.329462750483189 0.366153906359268 no 2140 0.370902972274361 3072 2849257 YMR203W TOM40 SGTC_3283 9109332 35.8195 µM -0.330546484360929 0.36573258026021 no 2141 0.370493537523907 2996 17027281 SGTC_1455 4262-0120 131 µM -0.331324258133704 0.365430302848781 no 2142 0.370199784888863 3150 1529587 SGTC_258 haloperidol 50.781 µM -0.33147420392757 0.365372036860052 no 2143 0.370143161473687 3019 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1523 st012844 44.7 µM -0.332380932293943 0.365019766281123 no 2144 0.369800817363781 3101 4274103 SGTC_1390 3413-2614 145 µM -0.333183544274458 0.364708040689301 no 2145 0.369497869471297 3056 3421432 SGTC_1422 4031-0024 15.5 µM -0.333397990150407 0.364624767419556 no 2146 0.369416940046401 3049 782427 SGTC_179 1273-0063 6.77 µM -0.333969477642739 0.36440287953835 no 2147 0.369201295456607 2979 3108139 SGTC_69 0096-0274 206.684 µM -0.334024909770333 0.364381359668091 no 2148 0.369180380934609 3274 6741392 SGTC_2370 9071495 200 µM -0.335321168384645 0.363878247934495 no 2149 0.36869141355046 3069 21791103 SGTC_1951 sophoraflavanone G 9.2 µM -0.335527906844091 0.363798029020419 no 2150 0.368613448459988 3005 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2651 TUB2.036 5 µM -0.336423364531355 0.363450641381047 no 2151 0.368275816443683 3152 15992207 YFL037W TUB2 SGTC_2697 mebhydrolin 72.4 µM -0.33657681011222 0.363391124312763 no 2152 0.368217970039526 3163 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_3212 9128307 49.47 µM -0.336975074786514 0.363236664443659 no 2153 0.368067844895724 2928 27243542 SGTC_3234 9132280 49.47 µM -0.337236085794363 0.363135448028308 no 2154 0.367969468198396 3069 17612295 SGTC_2750 bromebric acid 70.15 µM -0.33740174588544 0.363071212321427 no 2155 0.367907034355326 3160 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2403 6032726 181.2 µM -0.337960421529768 0.362854610853124 no 2156 0.367696506860746 3071 2881040 SGTC_1826 st055655 41.6 µM -0.338038809292127 0.362824223015837 no 2157 0.367666970932783 3071 676168 SGTC_1092 toremifene 6.32 µM -0.33851331201526 0.362640295511178 no 2158 0.367488198536277 2986 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1045 1348-1485 165 µM -0.340225854158401 0.361976741056656 no 2159 0.366843224746043 2998 6810614 SGTC_710 3448-4187 58 µM -0.340430166115563 0.361897604457682 no 2160 0.366766302284957 3042 3946412 SGTC_1839 st053978 48 µM -0.343533102667797 0.360696464808829 no 2161 0.365598720999762 3104 3788398 SGTC_2117 5521686 200 µM -0.3441288443925 0.360466011289351 no 2162 0.365374695740535 2993 803312 SGTC_1867 st057372 64 µM -0.344621281090517 0.36027555798275 no 2163 0.3651895524097 3025 688837 SGTC_1825 st052143 62.6 µM -0.344704801846685 0.360243259188693 no 2164 0.365158153902879 3180 674173 SGTC_1764 st044502 93.5 µM -0.34550395122074 0.359934265980668 no 2165 0.364857770157785 3139 8407 SGTC_1484 3473-2379 286 µM -0.346162481963511 0.359679712097321 no 2166 0.364610304367796 3054 671917 SGTC_2508 celastrol 40.54 µM -0.346453543601012 0.359567222567968 no 2167 0.364500945821303 3046 122724 Celastrol is a natural product and antioxidant. SGTC_3294 9122953 26.2835 µM -0.346751327478169 0.359452147618752 no 2168 0.364389072986988 2998 16459826 SGTC_2255 7941087 197.44 µM -0.348266539904206 0.358866809863814 no 2169 0.363820010027989 3159 935561 SGTC_1518 st038567 90.8 µM -0.350186644280328 0.35812553533703 no 2170 0.363099314647821 3077 77966 SGTC_140 0062-0056 502.533 µM -0.350870588944553 0.357861620961938 no 2171 0.362842718533721 2980 3758964 SGTC_576 1073-0113 22.7 µM -0.354578566128508 0.356432005559948 no 2172 0.361452667938553 3117 5439563 SGTC_1557 sumaresinolic acid 42.3 µM -0.354998644872349 0.356270170364319 no 2173 0.361295303219565 3023 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_98 0074-0023 107.663 µM -0.355597441750733 0.356039528816913 no 2174 0.361071029886838 3101 3563821 SGTC_1750 st081859 2.357 µM -0.356593407778044 0.355656024360182 no 2175 0.360698106648616 3074 5291695 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.356631522047149 0.355641351064151 no 2176 0.360683838010774 2950 4000243 SGTC_1912 st060209 90.8 µM -0.357238644390822 0.355407648929444 no 2177 0.36045657898447 3085 688787 SGTC_2268 7933382 153.85 µM -0.357426186094899 0.355335468704766 no 2178 0.360386388027794 3006 935025 YOR257W CDC31 SGTC_1724 st037281 8.293 µM -0.358067325837226 0.355088748873448 no 2179 0.360146465151945 3003 574124 YDL195W SEC31 SGTC_1488 4013-0813 75.9 µM -0.35838237888832 0.354967534161156 no 2180 0.360028588355442 3040 2910057 SGTC_559 1550-0661 158 µM -0.358610489473692 0.354879779185059 no 2181 0.359943249304809 3108 5830875 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.360055405028331 0.354324093896477 no 2182 0.359402850460938 3062 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1321 1326-2144 215 µM -0.360168744374288 0.354280518973828 no 2183 0.359360473387582 3140 3513030 SGTC_1023 4482-3888 16 µM -0.3602465791383 0.354250595397265 no 2184 0.359331372320111 3215 3303168 SGTC_2012 4023501 200 µM -0.360578140379107 0.354123136754784 no 2185 0.359207416469429 3116 3477460 SGTC_1356 1502-0781 85.8 µM -0.360991517936949 0.35396424920527 no 2186 0.359052893929823 3032 567702 SGTC_634 1611-4317 11.2 µM -0.364852128031405 0.35248159969391 no 2187 0.357610895385577 3148 2843522 SGTC_1118 chelidonine 707.474 nM -0.365259193536792 0.35232539813958 no 2188 0.357458967987506 3159 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1547 harmine 94.2 µM -0.365304101258327 0.352308167411159 no 2189 0.357442208644779 3072 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_3200 9114385 49.47 µM -0.365425995517309 0.352261399101119 no 2190 0.357396719687642 3180 17018030 YLR208W SEC13 SGTC_3221 9128209 49.47 µM -0.365922412651386 0.352070957180102 no 2191 0.357211485812699 3066 16460723 SGTC_945 3381-0768 11.3 µM -0.366878358294169 0.35170432956205 no 2192 0.356854877553895 3196 1126236 YIL048W NEO1 SGTC_218 alverine citrate 93.75 µM -0.36872608098151 0.350996075537608 no 2193 0.356165953328452 3185 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_164 4100-3994 89.624 µM -0.368835329640365 0.350954215405611 no 2194 0.356125234588806 3171 4615967 SGTC_2229 7354935 190 µM -0.368918476392842 0.35092235779159 no 2195 0.356094245550764 3123 318112 SGTC_2151 5563267 85.4165 µM -0.368997840133708 0.350891950613046 no 2196 0.356064667338886 3079 5310824 SGTC_148 3253-0744 288.01 µM -0.369918710166821 0.350539201180158 no 2197 0.355721530045591 3094 6893655 SGTC_1224 0823-0416 294 µM -0.369984626532486 0.350513956126487 no 2198 0.355696972575227 3186 3598164 SGTC_1594 piperine 70.1 µM -0.37039224251571 0.350357859528035 no 2199 0.355545126516535 3041 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1361 1608-0041 5.61 µM -0.373529885805453 0.349157146282386 no 2200 0.354377053297261 3056 X1361 SGTC_1218 1348-1416 30.7 µM -0.377731795727384 0.347551523544815 no 2201 0.352814922576625 3056 6787668 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.37776686637599 0.347538133894696 no 2202 0.35280189486507 3137 6708739 YPR165W RHO1 SGTC_41 0478-0632 82.643 µM -0.378052364954491 0.347429140249464 no 2203 0.352695846986667 3169 3750424 SGTC_1963 st076565 50.3 µM -0.378694984340666 0.347183856189407 no 2204 0.352457189181651 3076 4914280 SGTC_3051 9093778 49.47 µM -0.37875320243586 0.347161637843259 no 2205 0.352435570848371 3130 17217378 SGTC_1034 k072-0165 12.7 µM -0.378782848354263 0.347150323980741 no 2206 0.352424562506746 3219 5835461 SGTC_2154 5570129 200 µM -0.379704929857459 0.34679849525425 no 2207 0.35208223014242 3133 673366 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.381970417529942 0.345934638849351 no 2208 0.351241653664417 3231 1273210 SGTC_2054 5233173 129 µM -0.382168583115355 0.345859114088165 no 2209 0.351168161713784 3206 6889 SGTC_2985 9022375 71.43 µM -0.382570421704342 0.345705984410662 no 2210 0.351019152412173 3257 4939335 SGTC_1827 berberine 7.24 µM -0.383657546342086 0.345291837561791 no 2211 0.350616141030026 3073 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2092 5303694 80.6725 µM -0.384879778970207 0.344826441627036 no 2212 0.350163244042274 3088 1963699 SGTC_1754 st042065 16.137 µM -0.385315741141182 0.344660494772784 no 2213 0.350001750235558 3165 1126236 YIL048W NEO1 SGTC_1054 3429-0080 167 µM -0.3858958704258 0.344439717766165 no 2214 0.349786894561483 3245 1162877 SGTC_2301 7769476 200 µM -0.38620171450192 0.344323345486561 no 2215 0.349673642038137 3141 977820 SGTC_1565 sinapyl alcohol 95.1 µM -0.386637415418935 0.344157588723126 no 2216 0.349512327282922 3181 5280507 A phenol propionate derived from cinnamic acid. SGTC_1879 gemcitabine 100 µM -0.389092127036512 0.343224285769073 no 2217 0.348603998617832 3095 60750 A nucleoside analog which inhibits DNA replication. SGTC_88 0180-0332 8.668 µM -0.3898014633818 0.342954767528477 no 2218 0.348341680789496 3071 3101745 SGTC_1581 himbacine 57.9 µM -0.39020557396603 0.342801258065157 no 2219 0.34819227012496 3079 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.390498413671047 0.342690033278922 no 2220 0.348084014048197 3217 756377 SGTC_1437 4092-1038 11.6 µM -0.39088108472443 0.342544709790783 no 2221 0.34794256805464 3092 3977136 SGTC_2489 cantharidin 73.42 µM -0.391408518355096 0.342344449340331 no 2222 0.347747648415259 3096 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3026 9090633 49.47 µM -0.39164427016269 0.342254951434454 no 2223 0.34766053641979 3088 25236842 SGTC_1972 st070201 17.4 µM -0.392172165320859 0.342054579968379 no 2224 0.347465504520494 3216 2829099 SGTC_1335 1486-0900 202 µM -0.392743138253598 0.341837907671986 no 2225 0.347254602903123 3051 X1335 SGTC_1897 st060201 15 µM -0.392903744627106 0.341776970292745 no 2226 0.347195287867592 3112 611878 SGTC_1252 0493-0875 34.8 µM -0.393362662033815 0.341602870263074 no 2227 0.347025821437669 3076 3960963 SGTC_1288 0973-0013 65.5 µM -0.393445433248568 0.341571472836611 no 2228 0.346995259405883 3215 4315430 SGTC_1349 flufenamic acid 69 µM -0.396476292716432 0.340422539992162 no 2229 0.345876846833132 3083 3371 A non-steroidal anti-inflammatory. SGTC_126 0417-1624 672.48 µM -0.396989416277952 0.340228172176248 no 2230 0.345687632642818 3229 41912 YDL195W SEC31 SGTC_323 4013-0906 34.3 µM -0.398753208350139 0.339560383356362 no 2231 0.345037528919939 3195 2910086 SGTC_442 cape 100 µM -0.39970573056557 0.339199958374546 no 2232 0.3446866354123 3233 5281787 SGTC_1933 st074711 15.9 µM -0.399821712661593 0.339156081936035 no 2233 0.344643918633708 3144 17250958 SGTC_97 0535-0701 19.132 µM -0.400428409790007 0.338926601817921 no 2234 0.344420501378344 3122 2832013 YGL099W LSG1 SGTC_1129 3453-1384 223 µM -0.40234161324274 0.338203333997962 no 2235 0.343716316669958 3288 1084452 SGTC_2413 inermin 26.06 µM -0.40288393112772 0.33799842445753 no 2236 0.343516806488974 3347 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1726 st035556 14.5795 µM -0.403253019131382 0.337858995584583 no 2237 0.343381049767374 3289 5919439 SGTC_602 3130-1533 38.1 µM -0.405062076690854 0.33717591730553 no 2238 0.342715940729314 3220 720941 SGTC_1174 0739-0097 51.1 µM -0.408293815783564 0.335956987904096 no 2239 0.341528989486564 3134 728447 SGTC_2843 9000894 45.46 µM -0.409101472839853 0.335652628958126 no 2240 0.341232597725884 3167 2242070 SGTC_2784 7567673 72.73 µM -0.41035096720938 0.335181979656156 no 2241 0.340774254699786 3209 3471247 SGTC_2459 5811157 9.22 µM -0.412673066953249 0.334307997521895 no 2242 0.33992308005765 3181 2870684 YBR192W RIM2 SGTC_561 1550-0330 72.9 µM -0.412930281014917 0.334211243499955 no 2243 0.339828847333021 3133 6812934 SGTC_932 2857-0803 154 µM -0.414146583855331 0.333753866513238 no 2244 0.339383379305789 3326 674898 SGTC_784 4579-0127 173 µM -0.41423085444107 0.333722186647136 no 2245 0.339352523707574 3321 1948547 SGTC_361 000s-0510 1.45 µM -0.416215106476379 0.332976589171524 no 2246 0.338626303283639 3199 660 SGTC_1068 loratadine 26.9 µM -0.416309759652082 0.332941039002051 no 2247 0.338591675938597 3179 3957 A H1 histamine antagonist. SGTC_1480 1070-0044 41.2 µM -0.418050987267518 0.33228733082951 no 2248 0.337954919452534 3206 3124987 SGTC_125 0133-0007 11.75 µM -0.418477497585506 0.332127283956587 no 2249 0.337799017775804 3281 26541 SGTC_1749 st037932 54.2 µM -0.419046340710495 0.331913874723458 no 2250 0.337591132706343 3244 594497 SGTC_119 0121-0043 24.815 µM -0.419805329296257 0.331629214746749 no 2251 0.337313835696281 3217 1092378 SGTC_907 3448-6986 75.5 µM -0.419914202092254 0.331588389785213 no 2252 0.337274066185955 3319 590582 SGTC_3167 9103034 49.47 µM -0.420761359215103 0.331270792424142 no 2253 0.336964675232153 3212 5127859 SGTC_1309 pyrazolanthrone 13.4 µM -0.421629791142533 0.330945345113137 no 2254 0.336647628942357 3254 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1187 1391-0724 117 µM -0.422259423260972 0.330709468546859 no 2255 0.336417836026552 3211 6997986 SGTC_1855 st056195 39.6 µM -0.42272365718418 0.330535597485437 no 2256 0.336248446580444 3288 4028379 SGTC_2973 9094665 17.96 µM -0.422794156170383 0.330509196465235 no 2257 0.336222725851265 3333 25237061 YIL048W NEO1 SGTC_1154 4088-0362 150 µM -0.42317578710992 0.330366294923925 no 2258 0.336083505584283 3120 6618304 SGTC_749 1000-0129 128 µM -0.423629649841743 0.330196378419092 no 2259 0.335917964182021 3309 708470 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.426057531139132 0.329288026904602 no 2260 0.335032962549855 3233 279621 SGTC_466 geldanamycin 89.2 µM -0.42681498561904 0.329004843650192 no 2261 0.334757045314442 3169 5288382 HSP90 inhibitor. SGTC_1318 1280-3875 124 µM -0.428592911540919 0.328340530806307 no 2262 0.334109752492128 3209 373245 SGTC_702 1488-0190 94 µM -0.428687242733853 0.328305299577359 no 2263 0.334075422917126 3239 949357 SGTC_1980 st071811 45.7 µM -0.428815052426551 0.32825756708703 no 2264 0.334028911859872 3305 4974850 SGTC_347 4534-1311 26.2 µM -0.430382750519175 0.327672314498547 no 2265 0.333458620484763 3179 2862016 SGTC_231 b-estradiol 524 µM -0.432085317258551 0.327037192043408 no 2266 0.332839702844747 3150 450 A steroid. SGTC_1872 amphotericin b 148 nM -0.432512195100882 0.326878028718241 no 2267 0.332684595373104 3258 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_372 0155-0182 15.9 µM -0.432627005971511 0.326835226341119 no 2268 0.332642883350129 3138 771486 SGTC_1902 st060212 70.5 µM -0.432674671135841 0.326817457069919 no 2269 0.33262556669234 3281 688944 SGTC_1256 0570-0116 285 µM -0.434359430562555 0.326189641961067 no 2270 0.33201372662946 3189 410638 SGTC_1389 3405-0187 19 µM -0.435297240789689 0.325840385962022 no 2271 0.331673343713137 3200 799890 SGTC_3098 9119039 49.47 µM -0.435864668847216 0.325629140555849 no 2272 0.331467460302195 3247 17161528 SGTC_1043 0916-0009 19.3 µM -0.436071527102953 0.325552144087264 no 2273 0.331392417310047 3343 3101130 SGTC_42 0133-0086 60.653 µM -0.436669588671173 0.325329576388198 no 2274 0.331175493642679 3113 162923 Model of phenazepam hydroxylation. SGTC_2052 5265182 7.135 µM -0.438096835217425 0.324798680568713 no 2275 0.330658044246038 3295 1239884 SGTC_1611 st001856 99.4 µM -0.440555155032112 0.323885088640849 no 2276 0.329767537220608 3208 647478 SGTC_2842 9000675 19.48 µM -0.440949485038803 0.323738641238901 no 2277 0.329624783873311 3228 2989072 SGTC_1000 4048-0884 8.67 µM -0.442500466628896 0.323162898182359 no 2278 0.329063546353502 3280 13040088 SGTC_127 0180-0333 59.125 µM -0.443354567128626 0.322846026443413 no 2279 0.328754646255309 3260 771601 SGTC_858 0438-0351 2.77 µM -0.447068269495598 0.321469738180834 no 2280 0.327412884190155 3228 2799119 SGTC_1271 0832-2808 169 µM -0.447440203344047 0.321332034998232 no 2281 0.327278626730412 3309 3663794 SGTC_208 k072-0098 12.366 µM -0.447841229596302 0.32118358828144 no 2282 0.327133892777724 3204 5948901 SGTC_1935 st074532 41.6 µM -0.44842584944428 0.320967232442585 no 2283 0.326922944826945 3279 2829742 SGTC_699 0375-0592 111 µM -0.449874075674856 0.320431535430128 no 2284 0.32640062068856 3337 762578 SGTC_629 3448-6466 76.7 µM -0.450713897015128 0.32012105780766 no 2285 0.326097882524968 3245 573744 SGTC_77 0828-0286 12.516 µM -0.450766304007805 0.320101687384262 no 2286 0.326078994687814 3297 745345 SGTC_268 camptothecin 39.6153 µM -0.452396656019643 0.319499329553548 no 2287 0.325491627773958 3285 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3182 9108849 49.47 µM -0.45270164225603 0.319386700644763 no 2288 0.325381798429563 3298 17133045 SGTC_1945 st075991 56.6 µM -0.45468488981495 0.318654710481494 no 2289 0.324667976517639 3217 1084980 SGTC_2941 9056145 11.23 µM -0.454905836303862 0.318573205809367 no 2290 0.324588491973085 3257 2119517 SGTC_1302 1159-0335 255 µM -0.456012368811793 0.318165150551149 no 2291 0.324190541934015 3205 649284 SGTC_1892 st058411 7.36 µM -0.456873825902466 0.317847624274527 no 2292 0.323880869046502 3301 3934738 SGTC_1461 k072-0203 53.8 µM -0.457609005031641 0.317576748932274 no 2293 0.323616686381795 3229 5418714 SGTC_1622 st003707 19.4 µM -0.458603817152766 0.317210367770199 no 2294 0.323259347497014 3305 10140899 SGTC_384 k007-0144 5.16 µM -0.46024539079466 0.316606181304654 no 2295 0.322670046847901 3238 6824886 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.46056359607037 0.316489121358862 no 2296 0.322555867320631 3212 6708784 An antioxidant flavonoid SGTC_1495 4469-0029 237 µM -0.461204414746353 0.316253435616976 no 2297 0.322325977314523 3265 793680 SGTC_233 rapamycin 362 pM -0.46219790755124 0.315888187945665 no 2298 0.321969701826942 3303 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3254 9136651 49.47 µM -0.463690667661865 0.315339727531353 no 2299 0.321434692170749 3235 16454030 SGTC_3007 9078383 71.4286 µM -0.463716213401841 0.315330345214177 no 2300 0.321425539720811 3215 6496995 SGTC_838 0109-0203 71.4 µM -0.465174213218624 0.314795055529807 no 2301 0.320903351809661 3243 759422 SGTC_1450 4112-4260 37.6 µM -0.465912311491519 0.314524218511766 no 2302 0.320639134168648 3335 1633175 SGTC_1757 st041620 31.8375 µM -0.466119376316313 0.314448256275307 no 2303 0.320565027317252 3277 5289815 SGTC_3060 1327-0027 12.5 µM -0.466153887556018 0.314435596506411 no 2304 0.320552676714763 3245 16000455 YPR107C YTH1 SGTC_293 4049-0273 38.5 µM -0.4663469230969 0.314364789242589 no 2305 0.320483598385534 3235 1380311 SGTC_3347 9188721 44.724 µM -0.467140412983948 0.314073801397839 no 2306 0.320199711060786 3280 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2539 epi(13)torulosol 80 µM -0.467461520957391 0.313956077824043 no 2307 0.32008485797474 3311 6708597 SGTC_601 0986-0029 62.9 µM -0.468591243914575 0.31354205296049 no 2308 0.31968091860615 3263 24747981 SGTC_33 0986-0033 35.816 µM -0.469003647795006 0.313390972199247 no 2309 0.319533514313744 3283 2848082 SGTC_580 1123-0028 41 µM -0.470128181172056 0.31297916779876 no 2310 0.319131720601078 3291 1677248 YPR107C YTH1 SGTC_66 0109-0187 42.4 µM -0.470620943345954 0.312798791624846 no 2311 0.318955724472819 3337 759417 SGTC_2532 xanthone 78.9 µM -0.474367445309282 0.311428848312305 no 2312 0.317618951840514 3300 7020 An insecticide. SGTC_906 1165-0455 526 µM -0.474723600070854 0.311298752410056 no 2313 0.317491997170204 3265 3252859 SGTC_1313 1220-0047 237 µM -0.475394485432272 0.311053755998726 no 2314 0.317252912159925 3293 3528706 SGTC_2463 5473429 200 µM -0.475794894788636 0.310907572901518 no 2315 0.317110253651448 3268 5399405 SGTC_355 1311-2252 105 µM -0.476543619671244 0.310634305405451 no 2316 0.316843569642332 3241 5338538 SGTC_3058 9093861 49.47 µM -0.477744346091719 0.310196285766073 no 2317 0.316416088475496 3384 17217477 SGTC_1649 st011737 51.3 µM -0.477891624156875 0.31014257790406 no 2318 0.3163636715863 3284 1761035 SGTC_1509 1326-1131 80 µM -0.478230122899703 0.310019152988418 no 2319 0.316243212430181 3325 768313 SGTC_722 3534-0461 190 µM -0.479038248767256 0.30972457711323 no 2320 0.315955709248481 3287 658262 SGTC_2894 9048625 32.47 µM -0.479236151013857 0.30965245693034 no 2321 0.315885319443144 3411 4092861 SGTC_1531 st059297 52.4 µM -0.479268014409906 0.309640845852341 no 2322 0.315873986904894 3335 7566702 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.479373069130404 0.30960256507171 no 2323 0.315836624359687 3317 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2350 9023895 38.85 µM -0.480605460795612 0.309153649469035 no 2324 0.315398466798471 3361 2997209 SGTC_2561 acetosyringone 100 µM -0.480843318587773 0.309067039267445 no 2325 0.315313930037678 3194 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2447 5741742 33.78 µM -0.484188725524873 0.307850015745419 no 2326 0.314125968796914 3338 1776504 SGTC_679 0422-0091 41.4 µM -0.484340924485977 0.30779469748113 no 2327 0.314071968266163 3238 627384 YHR062C RPP1 SGTC_62 0180-0423 3.232 µM -0.484698712261495 0.307664673073392 no 2328 0.313945040044831 3280 30102 YGL099W LSG1 SGTC_1263 0774-1208 64.8 µM -0.485068665435206 0.30753025301371 no 2329 0.313813819191537 3404 906585 SGTC_3114 9122766 49.47 µM -0.485790094251508 0.307268200923598 no 2330 0.313557999127765 3298 17176985 SGTC_1471 k673-0312 37 µM -0.487770540086066 0.306549329000527 no 2331 0.31285619027965 3325 24099884 SGTC_14 0354-0009 295 µM -0.488995989533818 0.30610488161835 no 2332 0.312422268075775 3269 1713507 SGTC_2456 5770359 74.46 µM -0.489245041181011 0.306014590144411 no 2333 0.312334112574151 3375 3118787 SGTC_1530 rhein 70.4 µM -0.489304022505455 0.305993208712286 no 2334 0.312313236837853 3328 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1650 st011916 45.8 µM -0.49033414397544 0.30561988406465 no 2335 0.311948734825487 3382 242528 SGTC_1786 berberine 21.6 µM -0.490540562481786 0.305545100548083 no 2336 0.311875717061134 3323 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_971 1315-0384 26.7 µM -0.490772369808957 0.30546112856622 no 2337 0.311793727156825 3272 6769120 SGTC_1791 st048313 56.1 µM -0.49078128244906 0.305457900175165 no 2338 0.311790574955551 3330 1204976 SGTC_1460 k062-0059 9.15 µM -0.4917045739086 0.305123541886871 no 2339 0.311464102170578 3229 1373085 SGTC_3327 9140648 26.9345 µM -0.492065593310849 0.304992847490806 no 2340 0.311336487198805 3360 8029710 SGTC_1032 k061-1018 98.7 µM -0.492212285408142 0.304939749873516 no 2341 0.311284640207185 3423 4005393 SGTC_673 1082-0474 110 µM -0.493358950345695 0.304524837235019 no 2342 0.310879490945545 3283 3098046 SGTC_2558 carylophyllene oxide 100 µM -0.495570461559325 0.303725327767239 no 2343 0.310098748743753 3374 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1626 st003712 1.76 µM -0.49658925779225 0.303357326185952 no 2344 0.309739364955277 3375 24207035 SGTC_117 lucigenin 22.078 µM -0.497109962427934 0.303169318321327 no 2345 0.309555754824778 3351 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2771 fluoxetine 41.05 µM -0.498292173168505 0.302742657787508 no 2346 0.309139061832903 3418 3386 A selective serotonin reuptake inhibitor. SGTC_2416 tofa 880 nM -0.500295704548371 0.302020197017712 no 2347 0.308433439104928 3232 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2623 humulene 100 µM -0.505585360508908 0.30011651208844 no 2348 0.306573880381417 3341 6187145 An anti-inflammatory. SGTC_2803 7707263 71.43 µM -0.50697164924949 0.299618502031948 no 2349 0.306087355555681 3259 2199229 SGTC_2348 9022543 33.42 µM -0.50698921172518 0.299612195294612 no 2350 0.306081194109921 3379 3162678 YDL140C RPO21 SGTC_1606 st000094 49.2 µM -0.50707030303168 0.29958307594499 no 2351 0.306052745547204 3416 1242210 SGTC_584 0986-0246 15.4 µM -0.508573113713661 0.299043658896119 no 2352 0.305525739314655 3415 53315 YDR232W HEM1 SGTC_2225 6654152 15.4 µM -0.51218889400165 0.297747625637973 no 2353 0.3042594075345 3348 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1696 st025591 34.7925 µM -0.512218724279801 0.297736943995404 no 2354 0.304248969993495 3340 2787147 SGTC_546 peri-Naphthalide 147 µM -0.512256151690405 0.297723542214704 no 2355 0.304235874460096 3301 223824 A penicillin ester. SGTC_2611 pyromycin 23.93 µM -0.512588680901392 0.297604484254028 no 2356 0.30411953633695 3292 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1904 st060225 78 µM -0.513511069363383 0.297274348298223 no 2357 0.303796934837504 3373 66595 SGTC_3090 9117696 49.47 µM -0.514815491818078 0.296807762839913 no 2358 0.303340979375622 3300 7923821 SGTC_497 capsazepine 133 µM -0.515690747406202 0.296494876291885 no 2359 0.303035208973906 3313 2733484 A calcium channel blocker. SGTC_2377 9073351 62.6 µM -0.516179421218279 0.296320250854905 no 2360 0.302864550868784 3282 7337946 YHR072W ERG7 SGTC_1766 st045414 44.774 µM -0.516320865777755 0.296269715065778 no 2361 0.302815162635888 3380 253960 SGTC_1469 k284-2957 126 µM -0.516759473539368 0.296113032943658 no 2362 0.302662036787826 3342 23884841 SGTC_1837 st055472 66.5 µM -0.517060858526513 0.296005392417413 no 2363 0.302556837989372 3471 676091 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.517185608215008 0.295960842959472 no 2364 0.302513298754413 3407 6708760 SGTC_654 1124-0271 80.9 µM -0.517277391970986 0.295928067956982 no 2365 0.30248126684465 3314 5403748 SGTC_686 1319-0111 510 µM -0.517447758412349 0.295867236332034 no 2366 0.302421814140784 3451 4562600 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.518034598719822 0.295657741098251 no 2367 0.302217064856633 3356 16623 A steroid. SGTC_895 0964-0006 13.7 µM -0.518450093790698 0.295509455378846 no 2368 0.302072135757995 3416 6738897 SGTC_765 1319-0117 244 µM -0.518599601717019 0.295456105977564 no 2369 0.30201999343985 3363 3487746 YGL099W LSG1 SGTC_2708 st078559 56 µM -0.519602897412911 0.295098211366544 no 2370 0.301670189110736 3371 17250902 SGTC_785 1270-0111 65.3 µM -0.521402490685538 0.294456763044333 no 2371 0.301043208384906 3352 6741994 SGTC_3178 9107506 49.47 µM -0.521571932455762 0.294396400263745 no 2372 0.300984204909975 3428 8897194 SGTC_1196 1588-0294 184 µM -0.52357582600484 0.293682956949764 no 2373 0.300286799454281 3361 6144269 SGTC_230 MPP+ 141.667 µM -0.523952639428992 0.293548890052041 no 2374 0.300155740514297 3375 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2285 7945142 200 µM -0.524030574178552 0.293521165091853 no 2375 0.300128637368638 3389 2970608 SGTC_2263 7948595 193.29 µM -0.527209782237076 0.292391210386565 no 2376 0.299023958138109 3364 2971371 SGTC_2029 5175081 200 µM -0.52869132296558 0.291865332681999 no 2377 0.298509798721782 3376 1380876 SGTC_2267 7931562 200 µM -0.529570295285416 0.291553546966597 no 2378 0.298204947108708 3253 934880 SGTC_1991 st073000 8.92 µM -0.530256742720175 0.291310161008107 no 2379 0.297966967037384 3495 4301969 YIL048W NEO1 SGTC_484 loperamide 105 µM -0.530414210285056 0.291254342875707 no 2380 0.297912387823781 3357 3955 An opioid-receptor agonist. SGTC_1067 clotrimazole 1.36 µM -0.532117190710692 0.290651000074139 no 2381 0.297322415902718 3360 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1001 4048-4355 44.4 µM -0.53251603946813 0.290509777928157 no 2382 0.297184317946132 3382 21824233 SGTC_2792 7535235 81.82 µM -0.532680483752657 0.290451561763021 no 2383 0.297127389062755 3331 1281891 SGTC_2176 5809774 33.9695 µM -0.533325213353414 0.290223368852666 no 2384 0.296904238560599 3389 2870539 SGTC_3116 9124943 49.47 µM -0.534155046513355 0.289929784837767 no 2385 0.296617133891034 3337 41905195 YPL160W CDC60 SGTC_2544 sphondin 68.51 µM -0.534279483489145 0.289885772689292 no 2386 0.296574092303838 3460 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_35 0133-0054 64.071 µM -0.536043961777373 0.289262031377604 no 2387 0.295964083934191 3353 99677 SGTC_19 0279-0214 38.434 µM -0.537129746206554 0.28887852145246 no 2388 0.295588997426391 3437 3566274 YBR002C RER2 SGTC_2110 5483698 200 µM -0.538928836528552 0.288243592036929 no 2389 0.29496797943618 3362 2848765 YHR062C RPP1 SGTC_2502 avocadyne acetate 18.59 µM -0.540126852726944 0.287821157266324 no 2390 0.294554776610142 3371 3952079 SGTC_2682 pyrogallin 40.03 µM -0.540522633213599 0.287681664644841 no 2391 0.294418328311388 3385 822798 An ATP competetive kinase inhibitor. SGTC_2171 5739187 198.077 µM -0.540550313118163 0.287671910072663 no 2392 0.294408786547996 3278 2262761 SGTC_1609 st001574 46.4 µM -0.541069306566737 0.287489042469787 no 2393 0.294229906565242 3339 3960012 SGTC_1838 st055369 84.5 µM -0.541829198241682 0.287221393462156 no 2394 0.293968087495035 3391 676036 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.541845458345818 0.287215667618126 no 2395 0.293962486287923 3385 65057 A dermal irritant. YDR527W RBA50 SGTC_3217 9129673 49.47 µM -0.542137490517351 0.28711284041228 no 2396 0.293861896769884 3461 17248312 SGTC_3205 9113483 49.47 µM -0.542817164395782 0.286873588521982 no 2397 0.293627847015016 3456 17018033 SGTC_2061 5245884 80.95 µM -0.544165960823276 0.286399078879512 no 2398 0.293163636654505 3374 573863 SGTC_725 1497-0963 19 µM -0.544979014536944 0.286113224812887 no 2399 0.292883975411001 3455 3549977 SGTC_558 k064-0027 21.3 µM -0.545670253977645 0.285870304959924 no 2400 0.292646311330191 3402 5088526 SGTC_3199 9111318 49.47 µM -0.54720860206624 0.285330040933299 no 2401 0.292117713539123 3386 8548020 SGTC_2720 fluspirilene 36.88 µM -0.547655891788825 0.285173045208415 no 2402 0.291964101996974 3411 3396 An atypical antipsychotic. SGTC_1534 6-azauridine 81.6 µM -0.548622291815661 0.284833985844715 no 2403 0.291632342246921 3378 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_326 k292-0812 17.5 µM -0.548787398652156 0.284776077710892 no 2404 0.291575679571017 3406 3579357 SGTC_1306 1185-0270 9.02 µM -0.550069397660616 0.284326631827875 no 2405 0.291135887741297 3438 1548076 SGTC_422 cantharidin 155 µM -0.55040214484631 0.284210032066481 no 2406 0.291021788938856 3407 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_513 4245-1575 41.7 µM -0.550707753168625 0.284102962327945 no 2407 0.290917014443455 3377 719745 SGTC_1797 st048695 56.8 µM -0.553240587664956 0.283216328248154 no 2408 0.290049338899578 3426 592262 YIL048W NEO1 SGTC_2959 9079155 11 µM -0.555343302145824 0.282481270135809 no 2409 0.289329932837339 3471 16189457 SGTC_3177 9107506 49.47 µM -0.555640498705504 0.282377451450033 no 2410 0.289228320030828 3431 8897194 SGTC_1164 k060-0068 93.7 µM -0.555725425416869 0.282347787656628 no 2411 0.289199286298006 3460 5963676 SGTC_2762 leflunomide 42.06 µM -0.556364176769626 0.282124728187462 no 2412 0.288980961510725 3439 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.557308293398383 0.281795187035262 no 2413 0.288658405160373 3525 688751 SGTC_631 k072-0230 41.5 µM -0.557736459674418 0.281645798017065 no 2414 0.288512178559847 3454 5773147 SGTC_1175 0741-0056 27.6 µM -0.558987284791675 0.281209598729223 no 2415 0.288085199002045 3515 765927 SGTC_817 1391-0715 46 µM -0.559398292029508 0.281066339730338 no 2416 0.287944963383259 3383 1353946 SGTC_706 4262-0057 46.9 µM -0.56092200949207 0.280535546882508 no 2417 0.287425352603835 3414 883298 SGTC_1833 st055984 71 µM -0.56241073344149 0.280017413144192 no 2418 0.286918103876684 3386 676288 SGTC_1761 st044296 37 µM -0.564007919527976 0.27946204672518 no 2419 0.28637437122037 3430 1826700 SGTC_531 3788-1495 174 µM -0.564068561110035 0.27944097124998 no 2420 0.286353736549174 3400 2896655 SGTC_2194 5927483 104.545 µM -0.564652444944843 0.279238086809484 no 2421 0.286155092978138 3458 760979 SGTC_3314 9135860 59.4275 µM -0.564804364747121 0.279185310369971 no 2422 0.286103418957888 3482 25252478 SGTC_2027 5150920 200 µM -0.564882597670391 0.27915813440126 no 2423 0.286076810531154 3405 786715 SGTC_2123 5259487 200 µM -0.565274867835392 0.279021889913376 no 2424 0.285943410112187 3451 2173474 SGTC_1465 k213-0056 144 µM -0.565577096529046 0.278916940969371 no 2425 0.285840650521597 3369 24048857 YMR208W ERG12 SGTC_2139 5578692 56.4705 µM -0.568408937072781 0.277934518156071 no 2426 0.284878661683705 3424 650991 YMR113W FOL3 SGTC_530 4358-1714 28 µM -0.568503323140629 0.277901802823462 no 2427 0.284846624931297 3465 1564641 SGTC_3211 9128781 49.47 µM -0.569757036699046 0.277467429196438 no 2428 0.284421249513734 3391 17194361 SGTC_1126 isoteolin 1.0172 µM -0.56999087879118 0.277386446758944 no 2429 0.284341942278042 3444 133323 SGTC_314 1671-0008 2.74 µM -0.570592216844447 0.277178248962308 no 2430 0.284138047820921 3409 3913060 SGTC_2047 4141938 200 µM -0.570792291957801 0.277108995066929 no 2431 0.284070224269287 3413 3807862 SGTC_196 k015-0023 18.111 µM -0.572445620016887 0.276537037262518 no 2432 0.28351005846686 3446 5211998 SGTC_1676 st018489 23.4 µM -0.572828355356638 0.276404715070711 no 2433 0.283380459004655 3414 3696235 SGTC_883 0850-0245 24.6 µM -0.573032454858773 0.27633416492581 no 2434 0.283311359713563 3523 6823229 YPR165W RHO1 SGTC_2908 7930301 100 µM -0.573681671623152 0.276109811882496 no 2435 0.283091616654059 3397 2223178 SGTC_1800 st050079 29.0735 µM -0.574085605774437 0.275970267503833 no 2436 0.2829549366961 3454 3645560 SGTC_764 1951-2361 146 µM -0.576401870203878 0.27517075284299 no 2437 0.28217179030102 3374 5438930 SGTC_1413 3910-0535 34.4 µM -0.578886088380898 0.274314534378829 no 2438 0.281333018832185 3493 2876951 SGTC_994 3910-0338 138 µM -0.579034276101815 0.274263501134188 no 2439 0.281283022788575 3535 3479481 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.579452487396376 0.274119501810641 no 2440 0.281141948473544 3430 5379071 SGTC_1304 1165-0502 251 µM -0.579463307503129 0.274115776706248 no 2441 0.281138299003809 3427 767425 SGTC_2339 9000433 200 µM -0.580674669895005 0.273698891758035 no 2442 0.280729868261158 3401 2988954 SGTC_3134 9127454 49.47 µM -0.58226660384163 0.273151512157173 no 2443 0.280193558331539 3582 24262820 SGTC_1899 st063254 59.6 µM -0.582769725767259 0.272978628743155 no 2444 0.280024163835416 3436 3093813 SGTC_1886 st057356 49.9 µM -0.583162115973684 0.272843832772817 no 2445 0.279892085710974 3380 24207747 SGTC_1397 3532-0190 20.1 µM -0.583288519180867 0.272800417102726 no 2446 0.279849544961169 3409 5322280 SGTC_951 1171-0579 82.7 µM -0.584271126829366 0.272463038074718 no 2447 0.279518957286481 3498 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_822 1487-0950 154 µM -0.584323615473374 0.272445021893326 no 2448 0.279501303388649 3517 1958375 SGTC_2215 7188065 200 µM -0.584415084070951 0.272413627661988 no 2449 0.279470540365686 3514 940217 SGTC_1360 1598-0022 39.8 µM -0.586119667122307 0.271828902553293 no 2450 0.278897550372948 3487 761525 SGTC_1752 st044819 83.042 µM -0.586712283344691 0.271625763121286 no 2451 0.278698478362884 3415 441209 YML126C ERG13 SGTC_1845 st056753 3.01 µM -0.587232602808493 0.271447468207732 no 2452 0.278523749378763 3410 5375839 SGTC_1700 st030840 7.9285 µM -0.588444664262612 0.271032364220979 no 2453 0.278116932901775 3492 5499307 SGTC_1369 1866-0067 208 µM -0.588906379454802 0.270874320402098 no 2454 0.277962039018281 3529 3531355 SGTC_1105 epirubicin 18.1 µM -0.590095052506158 0.270467652678784 no 2455 0.277563462792238 3412 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2745 rifampicin 24.3 µM -0.592096900994584 0.269783472371429 no 2456 0.276892851006897 3429 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_73 0327-0325 16.231 µM -0.592859750835499 0.269522978167572 no 2457 0.27663750809898 3552 53298 SGTC_471 1-acyl-paf 4 µM -0.593826225049037 0.269193132428378 no 2458 0.276314173366865 3447 16759367 SGTC_1775 st081588 35.1725 µM -0.593970437137685 0.26914393198794 no 2459 0.276265942996835 3535 1426443 YGL099W LSG1 SGTC_3113 9123498 49.47 µM -0.59480826705085 0.268858181145797 no 2460 0.275985820440323 3539 8897275 SGTC_74 000s-0487 160.283 µM -0.595320079086348 0.268683697175168 no 2461 0.275814768335924 3504 677548 SGTC_1959 st077091 55.8 µM -0.595778472236186 0.268527472771375 no 2462 0.275661613530055 3500 821356 YKL052C ASK1 SGTC_386 1509-0011 3.07 µM -0.600764075360524 0.266831290008252 no 2463 0.273998567419403 3546 3107280 SGTC_931 2812-0076 566 µM -0.601541214724169 0.26656738317477 no 2464 0.273739784672442 3497 3450959 SGTC_2518 prenyletin 46.28 µM -0.601561923762056 0.266560352449785 no 2465 0.27373289034103 3470 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2144 5628481 200 µM -0.60168828030552 0.266517456394618 no 2466 0.273690826322624 3493 2818399 SGTC_26 0302-0163 425.158 µM -0.60181242815095 0.26647531355822 no 2467 0.273649500693012 3479 3100915 SGTC_866 0495-0101 262 µM -0.602113737777908 0.266373045961805 no 2468 0.273549215296649 3420 635694 SGTC_2426 5582046 32.21 µM -0.602872210017673 0.266115700602356 no 2469 0.273296852238158 3549 2251934 SGTC_2112 5488546 200 µM -0.603275536055865 0.265978905641723 no 2470 0.273162702358883 3469 600757 SGTC_2560 caryophyllene 100 µM -0.604147171146725 0.265683397343621 no 2471 0.272872900162163 3526 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_16 erodoxin 22.806 µM -0.604332681028228 0.26562052587753 no 2472 0.272811241318309 3557 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2477 5967686 25.23 µM -0.607027136879299 0.264708194803682 no 2473 0.271916451588764 3503 776118 SGTC_2524 avocatin b 10.57 µM -0.607806654805688 0.264444550923584 no 2474 0.271657857529428 3472 6710748 SGTC_1986 st071812 45 µM -0.608655504965752 0.26415760998553 no 2475 0.271376402802852 3510 11838594 SGTC_2740 felodipine 17.08 µM -0.609601101783464 0.263838152148804 no 2476 0.271063040800381 3498 3333 L-type calcium channel blocker SGTC_3029 9088683 49.47 µM -0.612079048214238 0.263001944962771 no 2477 0.270242729459802 3541 25236615 SGTC_380 3970-0968 6 µM -0.613407721491592 0.262554129783176 no 2478 0.269803390874584 3505 2891601 SGTC_141 0443-0274 32.331 µM -0.613508141026424 0.262520300317399 no 2479 0.269770200732449 3639 1627241 SGTC_1689 st020265 53.493 µM -0.613717595172772 0.262449746308293 no 2480 0.26970097961834 3562 5758320 YPR016C TIF6 SGTC_957 1187-1561 14.1 µM -0.615532422052739 0.261838833977839 no 2481 0.269101582234639 3524 1538454 SGTC_1013 4112-3890 241 µM -0.616257846150583 0.261594843796273 no 2482 0.268862177758217 3470 705171 SGTC_2582 agaric acid 100 µM -0.616671166907713 0.261455879104752 no 2483 0.268725821478834 3521 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1816 st051957 91.6 µM -0.616962792438057 0.261357853002252 no 2484 0.268629633881808 3537 674121 SGTC_2783 7738165 71.43 µM -0.619678741503083 0.260445829710772 no 2485 0.267734657144279 3481 17201110 SGTC_2966 9084041 48.03 µM -0.62030631635262 0.260235321687624 no 2486 0.267528068614792 3442 17741380 SGTC_734 2023-0417 80 µM -0.620814544413734 0.260064910547542 no 2487 0.267360826237317 3524 3935732 SGTC_836 0330-0104 1.35 µM -0.622705905961702 0.259431234417207 no 2488 0.266738900475891 3553 46494820 SGTC_413 propylparaben 100 µM -0.625117972555975 0.258624261507999 no 2489 0.265946816487771 3512 7175 A pharmaceutical preservative. SGTC_1704 st028805 70.8 µM -0.625428768007137 0.258520377423005 no 2490 0.265844842979874 3531 2876101 SGTC_958 1222-0007 33 µM -0.625671020844975 0.258439418852552 no 2491 0.265765372383581 3624 7312461 SGTC_322 k048-0136 19.3 µM -0.626044767721364 0.258314542005099 no 2492 0.265642789037045 3565 6823282 SGTC_911 3456-4043 236 µM -0.629865648502871 0.257039699989866 no 2493 0.26439124478085 3585 914281 SGTC_2193 5925765 200 µM -0.630142734831206 0.256947377194583 no 2494 0.264300600944915 3576 877370 SGTC_2362 9071156 126 µM -0.630627773136559 0.256785808121809 no 2495 0.264141967439443 3585 653133 SGTC_283 0987-0079 11.7 µM -0.632405855037496 0.256193971301414 no 2496 0.263560854501797 3582 411556 SGTC_1467 k284-1082 293 µM -0.634012444000776 0.255659828412947 no 2497 0.263036350507652 3560 3334705 SGTC_2761 levamisole 97.89 µM -0.634294902763701 0.255565979449625 no 2498 0.262944191208515 3601 26879 An alkaline phosphatase inhibitor. SGTC_2881 9058953 51.95 µM -0.634538729221621 0.255484980822655 no 2499 0.262864649950855 3530 17122249 SGTC_121 0557-0495 61.343 µM -0.634951723875604 0.255347815489063 no 2500 0.26272995058713 3662 3104427 SGTC_3071 9117417 49.47 µM -0.635550214265915 0.25514911094229 no 2501 0.262534813947423 3495 45595590 YGL055W OLE1 SGTC_2384 9036245 200 µM -0.636151812190354 0.254949456191168 no 2502 0.262338738891392 3537 6462766 SGTC_914 3820-6779 408 µM -0.636732100771279 0.254756950945692 no 2503 0.262149680142098 3541 2893481 SGTC_137 0438-0332 85.389 µM -0.637062473880672 0.254647386799731 no 2504 0.262042075365696 3601 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2149 5554786 194.827 µM -0.642217587325489 0.252940959403434 no 2505 0.260365957622424 3586 745063 YPR165W RHO1 SGTC_178 4092-0806 87.505 µM -0.642316856931719 0.252908158689178 no 2506 0.260333735691086 3579 2169044 SGTC_2717 st081029 62.2815 µM -0.642936282029198 0.252703538507925 no 2507 0.260132722850557 3557 5292846 SGTC_1281 0884-0031 11.8 µM -0.643339432720862 0.252570409019472 no 2508 0.260001937330782 3596 1548255 SGTC_695 3505-6186 243 µM -0.645090012446329 0.251992756777423 no 2509 0.259434427897662 3590 1819379 SGTC_1245 0418-0076 17.2 µM -0.645241073343789 0.251942942747159 no 2510 0.259385486421153 3583 6790114 SGTC_694 1315-0438 43.2 µM -0.646065985236557 0.251671010473143 no 2511 0.259118311442556 3536 6793154 SGTC_667 1498-1044 59 µM -0.646199682911206 0.251626951626434 no 2512 0.259075022434884 3597 6739982 SGTC_1780 st038448 24.544 µM -0.646921385467564 0.251389191518373 no 2513 0.258841412150831 3617 728868 YDL195W SEC31 SGTC_2235 salicylic acid 500 µM -0.647040075728799 0.251350101174639 no 2514 0.258803003347504 3594 338 A COX inhibitor and kinase inhibitor. SGTC_269 exalamide 29 µM -0.64802753277729 0.251025009250739 no 2515 0.258483571343864 3549 3316 A derivative of salicylamide. SGTC_1148 3909-7663 27.7 µM -0.649957712815012 0.250390195830382 no 2516 0.257859768585482 3652 4084526 SGTC_2610 ononetin 44.17 µM -0.651122265403234 0.250007600216557 no 2517 0.257483782346873 3599 259632 SGTC_1364 1653-0028 37.6 µM -0.652215278840765 0.249648790078353 no 2518 0.257131152425312 3569 5718652 SGTC_2939 9044578 71.43 µM -0.652390745166604 0.24959121417548 no 2519 0.257074566572409 3579 2653634 SGTC_779 1360-0071 233 µM -0.653285339932468 0.249297779790558 no 2520 0.2567861708616 3657 7566 SGTC_1298 1079-1278 263 µM -0.655906711689436 0.248439005693084 no 2521 0.255942074757304 3633 2840950 SGTC_595 3909-8003 73.7 µM -0.656718964670194 0.248173227979177 no 2522 0.255680818951903 3633 699517 SGTC_2233 sulbentine 40.3845 µM -0.65725867428954 0.247996713208128 no 2523 0.255507301955181 3587 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.657538318337676 0.247905280556967 no 2524 0.255417420412473 3578 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2914 7968218 45.32 µM -0.658257495517223 0.247670220444242 no 2525 0.255186342628979 3554 2977111 SGTC_793 0488-0545 106 µM -0.660173093541697 0.24704469631483 no 2526 0.254571378391757 3586 292548 SGTC_297 0986-0032 24 µM -0.660566180683207 0.246916441259346 no 2527 0.254445281731749 3575 2847425 SGTC_2004 4023728 41.89 µM -0.662673573501355 0.246229456775964 no 2528 0.253769819149557 3600 360084 YDR527W RBA50 SGTC_3228 9131799 49.47 µM -0.663520797408654 0.245953561169358 no 2529 0.253498532088963 3591 17015818 SGTC_661 1304-0007 33.6 µM -0.664476303272277 0.245642603054797 no 2530 0.253192755324302 3619 3117130 SGTC_655 k060-0012 42 µM -0.664956317366397 0.245486467842437 no 2531 0.253039216564646 3572 5994525 SGTC_2649 anisomycin 9.56 µM -0.666748198258797 0.24490409024764 no 2532 0.252466493150279 3593 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_578 3460-0051 92 µM -0.66724431690974 0.244742978692328 no 2533 0.252308043865698 3687 2876744 SGTC_1723 st034307 2.5525 µM -0.667488828805038 0.244663595917543 no 2534 0.252229971485054 3649 867466 SGTC_1773 st048542 73.5835 µM -0.667782484553674 0.244568276519094 no 2535 0.252136224365648 3570 3237138 SGTC_1947 st076332 61.6 µM -0.667800583216162 0.244562402425208 no 2536 0.252130447121718 3594 24208416 SGTC_2122 5258151 111.688 µM -0.668058270210837 0.244478775892467 no 2537 0.252048198860008 3605 2173356 SGTC_2815 7968870 71.43 µM -0.668981945356275 0.244179144472613 no 2538 0.251753497555734 3627 2977326 YHR190W ERG9 SGTC_1214 0358-0031 63.7 µM -0.669260215085221 0.244088915249777 no 2539 0.251664750447342 3670 4301366 SGTC_648 0375-0473 33.3 µM -0.670008285884865 0.243846441758774 no 2540 0.251426254083409 3632 1713139 SGTC_1932 st074806 40.9 µM -0.673712673374615 0.242647650175529 no 2541 0.250247001509022 3730 17251235 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.674131119758473 0.242512435940578 no 2542 0.250113978133556 3607 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_860 0443-0016 25.1 µM -0.674439083804826 0.242412948376226 no 2543 0.25001610086727 3650 5337942 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.674647389398456 0.242345667941842 no 2544 0.249949908617812 3654 229346 A bile salt which induces apoptosis. SGTC_1284 0929-0043 16 µM -0.675287546211757 0.242138967618539 no 2545 0.249746547341544 3615 1239883 SGTC_3179 9107801 49.47 µM -0.675908810622255 0.241938458894903 no 2546 0.249549271732473 3642 4818259 SGTC_1371 2421-0008 32.7 µM -0.675927652131897 0.241932379337563 no 2547 0.249543290114265 3617 2827552 SGTC_89 0302-0250 142.109 µM -0.676034752648505 0.241897822973501 no 2548 0.249509290336966 3694 4203518 YLR208W SEC13 SGTC_748 act1.228 77.9 µM -0.679361754640492 0.240825688683728 no 2549 0.248454338248961 3607 4421505 YNR035C ARC35 SGTC_1029 k015-0030 64.7 µM -0.6794517284566 0.240796730356574 no 2550 0.248425841688276 3671 2208316 SGTC_2318 6029776 164 µM -0.680320279526792 0.240517282189057 no 2551 0.248150843269599 3652 818325 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.681195415454548 0.240235894105988 no 2552 0.247873924269084 3656 5106787 A p450 inhibitor. SGTC_3263 9137018 49.47 µM -0.681881336411021 0.240015470997875 no 2553 0.24765699386694 3603 43844957 SGTC_2028 5153890 36.43 µM -0.683213627900499 0.239587649742618 no 2554 0.247235931249473 3633 2830968 YPR165W RHO1 SGTC_3158 9100007 49.47 µM -0.683676601751775 0.239439078555457 no 2555 0.247089700854551 3656 19297233 SGTC_325 2810-4341 181 µM -0.683832396797103 0.239389094273017 no 2556 0.247040503360412 3652 774970 SGTC_2587 piperic acid 92.2 µM -0.685929234206226 0.238716913244022 no 2557 0.24637886706867 3626 5370536 SGTC_1201 1889-3372 45.9 µM -0.688354596463644 0.23794070712776 no 2558 0.245614754202966 3587 5392199 SGTC_3043 9092303 49.47 µM -0.689008918437206 0.237731537025077 no 2559 0.245408827618224 3621 25236084 SGTC_39 0986-0283 58.349 µM -0.689635260148642 0.237531406028609 no 2560 0.245211793860334 3686 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_3119 9125183 49.47 µM -0.689882057340873 0.237452573889769 no 2561 0.245134180089001 3534 22695334 SGTC_44 0929-0055 61.211 µM -0.691254014706668 0.237014604220638 no 2562 0.244702962395081 3610 1379590 SGTC_2257 7960413 200 µM -0.691800300385397 0.23684033721941 no 2563 0.244531373989964 3637 2974689 YIL048W NEO1 SGTC_717 1532-0246 73.2 µM -0.691961602704231 0.236788894703395 no 2564 0.244480721306916 3658 9561992 SGTC_1336 1486-0901 104 µM -0.693933872118122 0.236160395919221 no 2565 0.243861840160886 3689 5006114 SGTC_1227 3909-8010 46.6 µM -0.694723330137974 0.23590907881351 no 2566 0.243614352182322 3651 15982272 SGTC_635 k038-0028 24.7 µM -0.69626992065277 0.235417162704921 no 2567 0.243129903379029 3693 4035102 SGTC_1573 oleylamine 1.06 µM -0.69659713816199 0.235313158914865 no 2568 0.243027473674929 3686 5356789 An amine of the fatty acid oleic acid. SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.697276661547921 0.235097258227246 no 2569 0.242814835378142 3645 6857784 SGTC_1654 st012436 41.8 µM -0.699212392758917 0.23448283074608 no 2570 0.242209653463714 3635 4323132 SGTC_1365 1672-3266 55.4 µM -0.70247580139976 0.233448994653867 no 2571 0.241191243795976 3676 6415873 SGTC_633 0437-0093 97.7 µM -0.702941241780717 0.233301751126789 no 2572 0.24104618402918 3662 2831118 SGTC_982 1491-0518 27.5 µM -0.703805086445161 0.233028607791934 no 2573 0.240777082830209 3651 3091256 SGTC_482 fipronil 114 µM -0.703965310590102 0.232977965254672 no 2574 0.240727188467697 3715 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_13 0199-0087 65 µM -0.705039255331294 0.232638678086418 no 2575 0.240392903598389 3712 4589825 SGTC_24 0417-1663 219 µM -0.705385301884962 0.232529411488152 no 2576 0.240285244191983 3648 4329390 SGTC_2952 9073731 13.78 µM -0.706054590778272 0.232318159872139 no 2577 0.240077094617036 3716 16457353 SGTC_733 4069-0007 56.1 µM -0.707172195907764 0.23196564167512 no 2578 0.239729737434652 3722 5717425 YNL287W SEC21 SGTC_1734 st037168 69.4 µM -0.707559232553144 0.231843630945237 no 2579 0.239609508499728 3723 708907 SGTC_2596 sinensetin 100 µM -0.707693352996011 0.231801358708649 no 2580 0.239567853050039 3710 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_3190 9110366 49.47 µM -0.71057071532274 0.230895503168502 no 2581 0.238675147791235 3627 17123768 SGTC_473 2-arachidonoylglycerol 10 µM -0.711212963250379 0.230693579882689 no 2582 0.2384761383506 3615 5282280 An endocannabinoid. SGTC_1243 0416-0003 5.65 µM -0.711554906518463 0.230586112889959 no 2583 0.238370219551588 3711 2141977 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.712057593417458 0.230428177694711 no 2584 0.23821455631999 3715 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3245 9134821 49.47 µM -0.712277863682793 0.230358991792967 no 2585 0.238146364453355 3680 17014901 SGTC_1128 3448-9350 235 µM -0.713290929726923 0.230040941892241 no 2586 0.237832874489492 3736 619386 SGTC_2248 tofa 1.1 µM -0.71389242842169 0.229852218995914 no 2587 0.237646849822599 3633 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1729 st035615 45.989 µM -0.713981411818473 0.229824307420494 no 2588 0.237619336831327 3741 17385451 SGTC_869 0564-0080 44.1 µM -0.714330915919735 0.229714696233561 no 2589 0.237511289730873 3727 6843321 SGTC_1063 disulfiram 1.84 µM -0.715089131594158 0.229477005944573 no 2590 0.237276984628559 3699 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1681 tripelennamine 100 µM -0.716171029025878 0.229138084594212 no 2591 0.236942874756578 3686 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_3047 9092122 49.47 µM -0.717396467597647 0.228754536053595 no 2592 0.236564749297783 3677 17173831 SGTC_142 0335-0849 62.6745 µM -0.71815128822599 0.228518465152009 no 2593 0.236332004648204 3719 3889043 YPR107C YTH1 SGTC_1767 st044992 70.3 µM -0.719390681745535 0.228131140600396 no 2594 0.23595011831272 3709 9600693 SGTC_1931 st074438 57.1 µM -0.720514240242356 0.227780335043662 no 2595 0.235604217583099 3679 2787313 SGTC_1260 0700-1617 7.75 µM -0.720580237914061 0.227759738218201 no 2596 0.235583908123471 3730 2853078 SGTC_726 3448-4391 34.2 µM -0.720967216408617 0.227638989469251 no 2597 0.235464842690038 3773 1356692 SGTC_1119 parthenolide 318.541 nM -0.72219016680105 0.227257629752077 no 2598 0.23508878404371 3838 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1070 indatraline 8.81 µM -0.722478710921207 0.227167703888023 no 2599 0.235000104791869 3712 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2486 5283202 22.39 µM -0.72317598470574 0.226950478699979 no 2600 0.234785885566647 3733 1377751 SGTC_2869 9037858 32.47 µM -0.725027420557917 0.226374260492713 no 2601 0.234217604282718 3677 27187042 SGTC_3265 9137266 49.47 µM -0.725438462994444 0.226246444859174 no 2602 0.23409154194674 3650 17224265 SGTC_1995 st072814 61.1 µM -0.725848171122277 0.226119084719199 no 2603 0.233965926230621 3693 5769371 SGTC_1919 st067113 52.3 µM -0.72735568485038 0.225650814343628 no 2604 0.233504047080834 3745 1268243 SGTC_45 0kpi-0036 14.9 µM -0.727636520835833 0.225563640534668 no 2605 0.233418059146095 3692 2795021 SGTC_2069 5228469 200 µM -0.732218707785201 0.224143987013525 no 2606 0.232017543789113 3694 2835210 SGTC_2620 irigenin 100 µM -0.732327593032873 0.224110314017066 no 2607 0.231984320734959 3747 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_122 0236-0016 402.397 µM -0.734567264068985 0.223418328609456 no 2608 0.231301540474923 3781 6808838 SGTC_1295 1013-0063 9.78 µM -0.734850414041996 0.223330931131848 no 2609 0.231215299999201 3732 6826038 SGTC_307 1501-1223 22.3 µM -0.735300363289353 0.223192089181829 no 2610 0.231078293503009 3710 2830329 SGTC_3322 9139058 2.11 µM -0.735699871829864 0.223068853039358 no 2611 0.230956683844458 3825 4908926 YPR165W RHO1 SGTC_3258 9138477 49.47 µM -0.736181125476901 0.222920452501203 no 2612 0.230810238582895 3774 4970355 SGTC_3145 9085516 49.47 µM -0.737224331386024 0.222598960166622 no 2613 0.230492969629813 3769 25236195 SGTC_234 nsc-17383 10.7 µM -0.738620703360825 0.222169044073305 no 2614 0.230068674482851 3745 408974 SGTC_788 1182-0090 188 µM -0.740502384707199 0.221590460770958 no 2615 0.229497607363042 3850 5715185 SGTC_2588 indole-3-carbinol 100 µM -0.740704074495027 0.221528495914295 no 2616 0.229436444162683 3752 3712 Induces cell cycle arrest. SGTC_2963 9082507 9 µM -0.741537616167767 0.221272513209804 no 2617 0.229183766378107 3767 16459611 SGTC_2730 imipramine 71.33 µM -0.7417282091689 0.221214005402972 no 2618 0.229126012410633 3744 3696 A tricyclic antidepressant. SGTC_2072 5231554 129 µM -0.741987937869465 0.221134288725115 no 2619 0.229047321914158 3796 789545 SGTC_2601 securinine 100 µM -0.743019025720466 0.220817986472949 no 2620 0.228735080882608 3713 442872 A GABA receptor antagonist. SGTC_2816 7982706 58.44 µM -0.743019788899487 0.220817752451888 no 2621 0.228734849860092 3768 2981853 SGTC_2460 5552655 174.22 µM -0.74387584070601 0.220555342331799 no 2622 0.228475796251718 3721 5401989 SGTC_2418 pentamidine 31.67 µM -0.745973654619795 0.219913044228509 no 2623 0.227841664950057 3722 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1684 st024538 14.6195 µM -0.746458834991349 0.219764647128017 no 2624 0.227695144817538 3735 6732859 SGTC_973 1325-0077 65.9 µM -0.747392576921922 0.219479214981118 no 2625 0.227413312425412 3780 2835149 SGTC_3054 9094397 49.47 µM -0.748778366222354 0.219055990963258 no 2626 0.22699540052595 3761 2598354 SGTC_639 0833-0042 114 µM -0.749089173828589 0.21896113390468 no 2627 0.226901729899001 3740 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_589 1227-0070 34.1 µM -0.749771227989517 0.218753056930129 no 2628 0.226696250102586 3768 2841384 SGTC_2476 5806916 10.51 µM -0.750422093218954 0.218554601036085 no 2629 0.226500264429728 3683 2870194 SGTC_160 3453-0671 289.699 µM -0.750545929323901 0.218516853800813 no 2630 0.226462986282194 3775 5322268 SGTC_481 bay k-8644 50 µM -0.751592685054294 0.21819793583998 no 2631 0.226148021832563 3735 2303 A calcium channel antagonist. SGTC_2947 9072639 7.68 µM -0.75296486298935 0.217780277132972 no 2632 0.225735514390916 3771 16488146 SGTC_562 3772-2733 112 µM -0.754016796153475 0.217460405918669 no 2633 0.225419568145138 3787 2876874 YIL048W NEO1 SGTC_1579 chlormadinone acetate 49.4 µM -0.755207162378372 0.217098767380877 no 2634 0.225062345903916 3780 45114258 A steroidal progestin. SGTC_247 mechlorethamine 29.705 µM -0.755458166183536 0.217022555697168 no 2635 0.224987062037996 3688 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_972 1319-0219 195 µM -0.755904034354185 0.216887215944747 no 2636 0.224853367473686 3734 23903702 SGTC_1774 st048371 48.465 µM -0.756197486193919 0.216798167592356 no 2637 0.22476539986835 3753 4242727 SGTC_1103 duloxetine 36.1 µM -0.758473275748752 0.216108294269 no 2638 0.224083852834885 3866 60835 A selective serotonin reuptake inhibitor. SGTC_926 2268-1401 59.4 µM -0.75951249128253 0.215793694146199 no 2639 0.223773022330333 3752 2931578 SGTC_840 0245-0196 390 µM -0.760135299418874 0.215605279676437 no 2640 0.223586857253865 3863 3827528 SGTC_2943 9068529 45.32 µM -0.760310865805281 0.215552183854368 no 2641 0.223534394202406 3783 3270634 SGTC_2840 9008771 71.43 µM -0.760598136965714 0.215465321972735 no 2642 0.223448566440407 3736 2992978 SGTC_2891 9063876 19.48 µM -0.761317682231617 0.215247842960996 no 2643 0.22323367081974 3773 6472478 SGTC_2506 ethyl hematommate 54.16 µM -0.762391535266647 0.214923513221791 no 2644 0.222913178391574 3857 3940691 An allergen. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.764283971681263 0.214352642769554 no 2645 0.222349017472837 3835 6708561 SGTC_1570 verbenone 133 µM -0.765942253767744 0.213853132821594 no 2646 0.221855331397836 3781 29025 A natural terpanoid with antifungal properties. SGTC_90 0870-0863 4.608 µM -0.767258092308872 0.213457256917235 no 2647 0.221464039845744 3760 1738164 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.768953950883041 0.212947680779615 no 2648 0.220960323948868 3841 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_563 tetrahydrosecaminediol 614 µM -0.769895626301014 0.212665030418655 no 2649 0.220680904278265 3838 334274 A psychoactive constituent of the cannabis plant. SGTC_1047 2043-3044 82 µM -0.770775181101085 0.21240122396876 no 2650 0.220420100320077 3800 669592 SGTC_1646 st011709 75.6 µM -0.770832535930836 0.21238402807511 no 2651 0.220403099710039 3728 5757843 SGTC_116 0155-0182 31.788 µM -0.770980624119923 0.212339632633638 no 2652 0.220359208197842 3752 771486 SGTC_2955 9076254 12.21 µM -0.771199126045763 0.212274137723565 no 2653 0.22029445607426 3741 16459619 SGTC_2685 mycophenolic acid 18.85 µM -0.771572054265973 0.212162381545743 no 2654 0.220183965572305 3776 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2444 5485484 36.41 µM -0.772878795802354 0.211771059112387 no 2655 0.219797057422728 3873 6790631 SGTC_3032 9089427 49.47 µM -0.774016724199664 0.211430634479636 no 2656 0.21946045064435 3771 17173707 SGTC_333 3486-0131 40.1 µM -0.774264650445964 0.211356506975422 no 2657 0.219387151724566 3841 6744690 SGTC_2250 alverine citrate 130 µM -0.777278449171178 0.210456628804317 no 2658 0.218497253444302 3712 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_978 1416-0512 87.4 µM -0.778391187218326 0.210124950067736 no 2659 0.218169216279156 3857 6814003 SGTC_414 piperonyl butoxide 100 µM -0.778867550494786 0.20998305228272 no 2660 0.218028870340513 3783 5794 A potent inhibitor of cytochrome P450. SGTC_452 diindolylmethane 8 µM -0.782507888683882 0.208900539077298 no 2661 0.21695807553692 3799 3071 Inhibits expression of several cancer promoting factors. SGTC_3012 9080433 71.4286 µM -0.782592311501988 0.208875473660427 no 2662 0.216933278929187 3794 17688859 SGTC_72 0744-0168 198.391 µM -0.78668779309928 0.207661640757458 no 2663 0.21573232580832 3725 677577 SGTC_808 0711-0032 135 µM -0.789211099379927 0.206915853918662 no 2664 0.214994317901795 3766 4252555 SGTC_1383 3049-0032 20.7 µM -0.791314735255957 0.206295317934238 no 2665 0.214380175912415 3869 712864 SGTC_623 k072-0108 16.9 µM -0.792406054280139 0.205973832796565 no 2666 0.214061975197248 3823 5382803 SGTC_2571 chrysanthemic acid 100 µM -0.794484357029289 0.205362420449519 no 2667 0.213456756057716 3853 2743 An insecticide. SGTC_1759 st043059 70 µM -0.79509473872541 0.205183058291642 no 2668 0.213279197449563 3837 669426 SGTC_1153 4055-0057 267 µM -0.795306712306121 0.205120791117957 no 2669 0.213217554983522 3857 882706 SGTC_528 3492-0019 172 µM -0.795335595350036 0.205112307602157 no 2670 0.213209156523948 3836 2869262 SGTC_2711 st079103 59.1 µM -0.795403921451425 0.205092239717813 no 2671 0.213189289787617 3799 54693780 SGTC_1350 1495-0454 146 µM -0.795498422282383 0.205064486043791 no 2672 0.213161814174626 3825 1069057 SGTC_3030 9087619 49.47 µM -0.795660021385508 0.205017031646186 no 2673 0.213114834882414 3857 25236973 SGTC_2764 methyldopa 94.69 µM -0.795957608622284 0.204929660722916 no 2674 0.213028337595759 3807 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2201 6605497 169.863 µM -0.796105158018152 0.204886348772583 no 2675 0.212985458197145 3788 670741 SGTC_192 3455-0609 60.9 µM -0.796578602734997 0.204747409603183 no 2676 0.212847904217448 3899 3769639 SGTC_557 1315-0110 16.2 µM -0.797354993522706 0.204519687887125 no 2677 0.212622444973823 3828 6833801 SGTC_2310 7668677 200 µM -0.802581299190173 0.202990696342311 no 2678 0.211108390408947 3810 2197143 SGTC_2430 5571206 200 µM -0.804085122631968 0.202552010395737 no 2679 0.210673908018879 3864 1731771 SGTC_2630 antimycin a 100 µM -0.804154066626909 0.202531912081688 no 2680 0.210654001409365 3832 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_190 3970-0790 3.722 µM -0.804285476425811 0.202493607255259 no 2681 0.21061606173345 3752 2832352 SGTC_867 0518-0118 155 µM -0.804660465757581 0.202384324906382 no 2682 0.210507819603568 3852 6848158 SGTC_2667 digitoxin 100 µM -0.806030513740468 0.20198535464477 no 2683 0.210112627572015 3806 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1485 3909-9022 254 µM -0.806058670933775 0.201977159957595 no 2684 0.210104510168157 3870 714516 SGTC_1562 morin hydrate 59.1 µM -0.807239227209174 0.201633757617066 no 2685 0.209764334821818 3911 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1370 2001-0092 44.6 µM -0.807281624262317 0.201621431594909 no 2686 0.209752124207155 3894 790957 SGTC_2739 tacrine 100.86 µM -0.807340192442066 0.201604404911476 no 2687 0.209735256895003 3870 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2015 5119600 184 µM -0.807588380791631 0.201532262246595 no 2688 0.209663788872582 3865 2828786 SGTC_2581 avocatin a 64 µM -0.808747091907846 0.201195656214689 no 2689 0.209330317353383 3860 6710728 A skin care supplement. SGTC_828 2074-0507 139 µM -0.810883011901575 0.200576054779919 no 2690 0.208716428472825 3922 X828 SGTC_797 k781-0471 270 µM -0.811669304108764 0.200348250905107 no 2691 0.208490706181568 3829 23738129 SGTC_946 3434-1334 87.4 µM -0.814662170840884 0.19948258304223 no 2692 0.207632856350246 3846 4047976 SGTC_337 1315-0038 354 µM -0.815830297442377 0.199145321572127 no 2693 0.207298601145997 3825 1626437 SGTC_747 3448-8087 38.7 µM -0.817707640825335 0.198604015214076 no 2694 0.206762073223845 3889 5168703 SGTC_805 3852-0218 479 µM -0.81858183830959 0.198352255411084 no 2695 0.206512516221981 3800 6615355 SGTC_2862 9027634 71.43 µM -0.819277067181963 0.198152174262986 no 2696 0.206314176795136 3795 5012562 SGTC_1820 st053765 18.6 µM -0.823680233459976 0.196887811230055 no 2697 0.205060636845707 3889 3690829 SGTC_2329 6138490 200 µM -0.823763690238857 0.196863893996358 no 2698 0.205036921284798 3994 720019 SGTC_3166 9102297 49.47 µM -0.826179701452885 0.196172270823591 no 2699 0.204351080546919 3894 25237072 SGTC_3094 9117742 49.47 µM -0.826524966224839 0.196073553540069 no 2700 0.204253180801117 3811 17149698 SGTC_1267 0828-0272 9.49 µM -0.828145796551422 0.195610532447255 no 2701 0.203793968166149 3928 745334 SGTC_2759 disulfiram 3.38 µM -0.828282998344655 0.19557136863861 no 2702 0.203755124512512 3801 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_839 0122-0028 230 µM -0.828504943695025 0.195508025136838 no 2703 0.203692298175634 3859 759448 SGTC_3004 9076122 71.4286 µM -0.828902691554268 0.195394538538762 no 2704 0.203579736112583 3898 44782551 SGTC_1049 3226-0134 66 µM -0.829667900169009 0.195176319525434 no 2705 0.203363287556304 3912 5702385 SGTC_2789 5281112 71.43 µM -0.83012941498563 0.195044778280354 no 2706 0.203232808890641 3914 765948 SGTC_3089 9117425 49.47 µM -0.830343457267603 0.194983790111827 no 2707 0.203172312193485 3842 9401657 SGTC_872 0588-0139 234 µM -0.831446194197537 0.194669765390659 no 2708 0.202860806121097 3855 2047100 SGTC_843 0310-0051 143 µM -0.832397890364796 0.19439899984279 no 2709 0.202592196220135 3906 2065037 SGTC_2361 9034121 116 µM -0.832599257442199 0.194341738620654 no 2710 0.202535388966255 3882 6496917 SGTC_2749 bexarotene 57.39 µM -0.833743186170872 0.19401664323708 no 2711 0.202212858313964 3924 82146 An retinoic acid receptor inhibitor. SGTC_2313 7726885 200 µM -0.833943795184924 0.193959665930205 no 2712 0.202156328295755 3911 726423 SGTC_600 1495-0418 41.6 µM -0.834185715956711 0.193890968752929 no 2713 0.202088169532267 3864 5377768 SGTC_2387 9077560 195.08 µM -0.834843274367744 0.193704319729092 no 2714 0.20190297851129 3858 5303272 SGTC_1733 st037357 54.9 µM -0.835059151531738 0.193643066540109 no 2715 0.201842202250639 3808 1272339 YGL099W LSG1 SGTC_21 0849-0113 22.993 µM -0.837527202480602 0.192943619177248 no 2716 0.201148146506573 3838 1560156 SGTC_2312 7706453 155.7 µM -0.838346602554334 0.192711742225963 no 2717 0.200918034819447 3910 976098 SGTC_344 k064-0035 6.43 µM -0.840006440688489 0.192242557022032 no 2718 0.200452387658179 3855 5088750 SGTC_526 4469-0568 170 µM -0.840519112340487 0.192097781862253 no 2719 0.200308695060067 3844 2901964 SGTC_1011 4112-3381 17.4 µM -0.841666822323294 0.191773917909475 no 2720 0.199987237130747 3985 2877139 SGTC_687 k029-0044 34.9 µM -0.843133149939321 0.19136063231794 no 2721 0.199576990340481 3947 5829338 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.843699671707797 0.191201104005226 no 2722 0.1994186255222 3929 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2926 9010726 65.15 µM -0.847217822183818 0.190212245433193 no 2723 0.198436860719837 3940 2994293 SGTC_368 fentichlor 4.58 µM -0.848214005156948 0.189932816706644 no 2724 0.198159399474028 3935 7329 A pesticide. SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.849545817585726 0.18955963856307 no 2725 0.197788823339055 3800 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_211 3455-0679 143.504 µM -0.850642890109426 0.189252574404741 no 2726 0.19748387822189 3963 748649 SGTC_2670 beta-carotene 100 µM -0.852160075435729 0.18882842806941 no 2727 0.197062626176922 3821 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2982 9019404 25.97 µM -0.853598909329884 0.188426727409704 no 2728 0.196663631531103 3864 22333232 SGTC_1261 0712-0010 12.7 µM -0.853908025669999 0.188340495632055 no 2729 0.196577976181187 3897 2840123 SGTC_161 4065-0411 162.148 µM -0.854299989554177 0.188231187532021 no 2730 0.196469396494763 3952 1906281 YLR208W SEC13 SGTC_547 1120-0019 610 nM -0.856520452936435 0.187612699752761 no 2731 0.195854982307873 3836 3676939 SGTC_2295 7971645 200 µM -0.856653438198596 0.187575697937963 no 2732 0.195818221613738 3978 2978226 YKL099C UTP11 SGTC_770 0389-1121 67.2 µM -0.856788206919043 0.187538204494468 no 2733 0.195780972196127 4049 6753108 SGTC_3348 9149464 3.537 µM -0.857062384764923 0.187461940915783 no 2734 0.195705204051176 3887 1951442 SGTC_3127 9126946 49.47 µM -0.857285092820466 0.187400007959185 no 2735 0.195643672516473 3905 27243249 SGTC_55 0767-0285 6.563 µM -0.859349255814125 0.186826586218488 no 2736 0.195073928408032 3842 3116166 SGTC_1783 st039459 87.517 µM -0.859506196997046 0.18678303263156 no 2737 0.195030651267551 4026 729761 SGTC_2246 7293507 91.5585 µM -0.859861397579234 0.186684482228325 no 2738 0.194932724884803 3964 887656 SGTC_1844 rapamycin 4 nM -0.860647846546323 0.186466396524713 no 2739 0.194716012667246 3848 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_291 SEC14.278 35.5 µM -0.862251256416129 0.186022253088407 no 2740 0.194274634697142 3929 1068044 SGTC_525 k781-2675 26.7 µM -0.864239311121953 0.185472474881664 no 2741 0.193728220593578 3902 3651118 YDL195W SEC31 SGTC_1372 2752-0194 270 µM -0.866699969348581 0.184793400783367 no 2742 0.193053211124302 3880 823334 SGTC_819 1013-0258 27.7 µM -0.867554897505082 0.184557826304308 no 2743 0.192819023196275 3945 5753198 SGTC_1150 3909-7983 10.9 µM -0.867833921921161 0.184480981886292 no 2744 0.192742628447348 3902 23965914 SGTC_2663 amphotericin b 100 µM -0.868207201059002 0.184378210474552 no 2745 0.1926404564015 3901 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2741 miltefosine 3.04 µM -0.868226605619454 0.184372868974711 no 2746 0.192635145990228 3885 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_3271 9137798 49.47 µM -0.869714385341482 0.183963614053883 no 2747 0.192228254414453 3852 6498326 SGTC_2351 9026858 72.31 µM -0.870057379357555 0.183869344370345 no 2748 0.192134523905137 3855 1409300 SGTC_2241 6772625 37.8075 µM -0.870706046533293 0.18369114466962 no 2749 0.191957338077003 3830 2285411 SGTC_503 tyrphostin 8 294 µM -0.873700575174565 0.18286989337537 no 2750 0.191140668820616 3913 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1466 k213-0079 57.5 µM -0.874089111414515 0.182763505285049 no 2751 0.191034863393519 3869 3657981 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.875791987891883 0.182297683519593 no 2752 0.190571563250365 3929 390807 SGTC_459 nigericin 15.3 µM -0.876639839676203 0.182066030616744 no 2753 0.190341146383291 3985 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1178 0988-0033 191 µM -0.877524640549229 0.181824478698531 no 2754 0.190100870578835 4002 5392207 SGTC_2696 st077691 74.316 µM -0.878534507094791 0.181549028760105 no 2755 0.189826859933065 3985 757133 SGTC_3336 9143619 71.43 µM -0.879431916983291 0.181304471645506 no 2756 0.189583566458676 3955 45595730 SGTC_1328 1441-0025 69.2 µM -0.87980183438807 0.181203723898077 no 2757 0.189483335381512 3897 4562601 SGTC_1526 st051518 75 µM -0.880011560984765 0.181146620017242 no 2758 0.18942652333839 3955 673993 SGTC_1171 0368-0077 21.4 µM -0.882358913888644 0.180508257444565 no 2759 0.188791373299622 3901 3239779 SGTC_324 1315-0088 19.6 µM -0.883122113961332 0.180301009542919 no 2760 0.188585148616465 3919 6787421 SGTC_250 brefeldin a 552.239 µM -0.88338835543275 0.180228746494064 no 2761 0.188513240061231 3814 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1762 st045503 25.4615 µM -0.884447725780014 0.179941393128651 no 2762 0.188227284647131 4044 4645554 SGTC_1158 4092-0494 91.8 µM -0.884592444825978 0.179902160551314 no 2763 0.188188241482296 4043 1148199 SGTC_728 3030-5151 22.5 µM -0.886251084237831 0.179452895763184 no 2764 0.18774112081592 3974 3125388 SGTC_369 0957-0393 4.5 µM -0.886441051916016 0.179401485516171 no 2765 0.187689953000304 3983 6997992 SGTC_2661 dactinomycin 12.96 µM -0.887509228360325 0.179112581337679 no 2766 0.187402399991139 3934 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2269 7935389 174.42 µM -0.887703091847473 0.179060179475843 no 2767 0.18735024116796 3900 97605 SGTC_334 1502-1024 68.5 µM -0.888153703184153 0.178938415197376 no 2768 0.187229039209525 4000 3296216 SGTC_3001 9076041 71.4286 µM -0.888466078230636 0.178854035744304 no 2769 0.187145047443298 3938 16004211 SGTC_336 4111-0029 111 µM -0.889397649535517 0.1786025463438 no 2770 0.186894703870531 3949 3131175 SGTC_1176 0848-0131 83.3 µM -0.891508099427333 0.178033628048795 no 2771 0.186328324176876 4007 6769040 SGTC_2311 7694451 200 µM -0.892104343177676 0.177873104633573 no 2772 0.186168503589667 3924 2163142 SGTC_1403 3909-7815 62.9 µM -0.892757450880485 0.177697376846224 no 2773 0.185993538395922 3897 6615483 SGTC_2358 9037157 4 µM -0.894744282032928 0.177163465821501 no 2774 0.18546190061694 3961 2388925 SGTC_1669 st015249 58.4 µM -0.895447445418229 0.176974751320744 no 2775 0.185273973833648 4038 722793 SGTC_1079 idarubicin 2.36 µM -0.897560667994665 0.176408370964959 no 2776 0.184709907973952 3971 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.897666761276641 0.176379966385611 no 2777 0.184681617503859 3944 803109 SGTC_2265 7929201 200 µM -0.898950528902825 0.17603648992865 no 2778 0.184339505994732 3933 1265108 SGTC_732 3970-1727 52.7 µM -0.901256075394729 0.17542069702515 no 2779 0.183726091142361 4035 1275699 SGTC_2070 5230947 200 µM -0.901521308004127 0.175349943217913 no 2780 0.183655604875695 4037 2835538 SGTC_1987 st072290 61.9 µM -0.901807673028039 0.175273572415748 no 2781 0.183579521533762 3994 54697379 SGTC_2396 5342950 42.78 µM -0.904461484475755 0.174566830104745 no 2782 0.182875374248124 3972 1886677 SGTC_1740 st038286 13.222 µM -0.904741766319968 0.174492293440088 no 2783 0.182801104396845 4035 716786 SGTC_3173 9105693 49.47 µM -0.905538893721841 0.174280420127329 no 2784 0.182589982332271 3988 17096658 SGTC_2183 6420625 130.508 µM -0.906573042300905 0.174005791239441 no 2785 0.182316311377849 3954 2897619 SGTC_150 3970-0969 77.2 µM -0.908618210155084 0.173463486289707 no 2786 0.181775845409894 4068 6615640 SGTC_2223 6903751 107.57 µM -0.909808891696401 0.173148256379686 no 2787 0.181461652248037 3944 5598863 SGTC_409 arachidonic acid 100 µM -0.909826559496717 0.173143581623246 no 2788 0.181456992687625 3976 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2732 terfenadine 20 µM -0.910531739396568 0.172957062386459 no 2789 0.181271075495946 3985 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1683 st010134 710 nM -0.91102415490162 0.172826895014801 no 2790 0.181141323343237 3977 3818134 SGTC_1040 k898-0338 155 µM -0.91140675476317 0.172725799926549 no 2791 0.181040547935165 3978 20969351 SGTC_729 4092-0585 94.1 µM -0.912442817389567 0.172452228427945 no 2792 0.18076782921834 4001 2169061 SGTC_343 4130-2827 29.8 µM -0.913617741997168 0.172142325131232 no 2793 0.180458870221376 4022 1118244 SGTC_402 epigallocatechin gallate 10 µM -0.917140571849359 0.171215260063251 no 2794 0.179534491588627 3932 65064 An antioxidant. SGTC_18 0111-0177 500 nM -0.917485753013966 0.171124594508577 no 2795 0.179444077586966 4035 721752 SGTC_2638 epoxomicin 18 µM -0.917778926105353 0.171047613553741 no 2796 0.179367308649282 3988 9915668 A protesome inhibitor. SGTC_3020 9089140 49.47 µM -0.920041467803431 0.170454263996993 no 2797 0.178775544852072 4041 17217859 SGTC_144 4161-2749 112.381 µM -0.920155259333698 0.170424457124229 no 2798 0.178745815374636 3918 797501 YMR168C CEP3 SGTC_1048 3161-0300 24.5 µM -0.920972566297607 0.170210467546826 no 2799 0.178532375057433 3982 2165101 SGTC_1186 1319-0216 26 µM -0.922093504228606 0.169917260570136 no 2800 0.178239902470151 4057 4565136 SGTC_54 0159-0055 9 µM -0.924466361844406 0.169297654290214 no 2801 0.177621778666041 3964 3319099 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.928487424255797 0.168250980675456 no 2802 0.176577394074999 4001 689007 SGTC_1276 0871-0068 94.2 µM -0.928949084909414 0.168131078388799 no 2803 0.176457736661466 4010 3414906 SGTC_766 1391-0721 126 µM -0.9318012074324 0.167391545899429 no 2804 0.175719635267088 4065 1020919 YIL115C NUP159 SGTC_3351 9150312 21.596 µM -0.932192456014542 0.167290262020356 no 2805 0.175618536742056 3926 4904905 SGTC_2320 7373003 200 µM -0.932680217861729 0.167164048745447 no 2806 0.175492550844951 4103 5415828 SGTC_2924 9010168 62.78 µM -0.933139443986186 0.167045275496897 no 2807 0.175373987920939 4115 2993929 SGTC_501 nsc-95397 161 µM -0.937304803363952 0.165970442185652 no 2808 0.174300896433821 4080 262093 SGTC_370 0180-0345 38.7 µM -0.938789983074418 0.165588288270178 no 2809 0.173919291426705 3892 3989527 SGTC_1636 st007707 68.9 µM -0.939365785773535 0.165440280782151 no 2810 0.173771486566088 4059 403051 SGTC_136 0097-0015 404.482 µM -0.94215727102499 0.16472395570284 no 2811 0.173056063274185 4018 4861337 SGTC_2704 st078022 71.1 µM -0.942570158457769 0.164618175188752 no 2812 0.172950404818417 4074 54697681 SGTC_465 cgp-37157 41 µM -0.942707659452442 0.164582957621254 no 2813 0.172915227252011 3968 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2734 clemastine 41.6 µM -0.944060280197094 0.164236776677302 no 2814 0.172569422580293 4045 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2177 5811945 192 µM -0.946598641270508 0.163588400566748 no 2815 0.171921668286215 4070 5343475 SGTC_890 0929-0006 47.2 µM -0.947095851168267 0.163461592672461 no 2816 0.171794969326291 4004 1378169 SGTC_3028 9087778 49.47 µM -0.947980014941201 0.163236254212152 no 2817 0.171569814179661 4004 17217395 SGTC_651 3253-0966 34.4 µM -0.950647657369654 0.162557601230461 no 2818 0.170891633708974 4042 781462 SGTC_1398 3558-0053 112 µM -0.950830128161783 0.162511247512418 no 2819 0.170845307894088 3930 4532369 SGTC_1812 st052057 4.327 µM -0.952082706065905 0.162193282792576 no 2820 0.170527519468284 4050 3645418 SGTC_3292 9120825 59.784 µM -0.95376845805346 0.161765997451129 no 2821 0.1701004294101 4035 24824900 SGTC_2286 7945697 125 µM -0.955298750292853 0.161378752070795 no 2822 0.169713319654252 4073 1245733 SGTC_483 fpl-64176 144 µM -0.95899725144727 0.160445332850068 no 2823 0.168780064916528 4099 3423 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.964976793230058 0.158943706697764 no 2824 0.167278217772031 3960 5355888 SGTC_154 3389-1638 511.116 µM -0.965062890582221 0.158922152778013 no 2825 0.167256656290139 4054 5238686 SGTC_690 glyoxal 20.3 µM -0.966831220558624 0.15847988641225 no 2826 0.166814207174465 3853 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1893 st059353 36.1 µM -0.970573073452005 0.157546698118931 no 2827 0.165880460009924 4058 3112488 SGTC_617 3770-0098 35 µM -0.971073663511498 0.157422129342782 no 2828 0.165755798769547 3975 5962639 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.97246853483481 0.157075365743261 no 2829 0.165408755531906 4068 7104 SGTC_3349 9149703 23.001 µM -0.972797631576314 0.156993625929149 no 2830 0.165326945026448 4068 4910494 SGTC_1846 st056244 14.8 µM -0.973719147088651 0.156764892260779 no 2831 0.165098003843056 4085 5393182 SGTC_3112 9123419 49.47 µM -0.975246241123688 0.156386328224615 no 2832 0.164719064902185 4099 17015854 SGTC_2198 6589944 200 µM -0.97704879944587 0.155940252469573 no 2833 0.16427249689759 4058 5290268 SGTC_649 1123-0311 367 µM -0.977776234520549 0.155760473228942 no 2834 0.16409250378221 3971 693629 YIL048W NEO1 SGTC_2056 5235370 200 µM -0.979444562291137 0.155348676905633 no 2835 0.16368018393567 4019 5511916 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.980623333285651 0.155058152302994 no 2836 0.163389261746655 4082 2374 Ca(2+)-ATPase inhibitor. SGTC_2083 5306046 65.942 µM -0.982523687026945 0.154590539405278 no 2837 0.162920959688638 4081 539837 SGTC_2423 st077119 87.2 µM -0.983459196535632 0.154360684786835 no 2838 0.162690743990324 3995 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2252 omeprazole 400 µM -0.984375894246152 0.15413567153753 no 2839 0.162465362976443 4018 4594 A proton pump inhibitor. SGTC_608 k048-0125 159 µM -0.98624402920104 0.153677789792778 no 2840 0.162006689092953 4122 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_451 chloral hydrate 100 µM -0.986303713380096 0.153663176001371 no 2841 0.16199204905106 4097 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1273 0849-0096 14.1 µM -0.988051475921505 0.153235640799963 no 2842 0.161563719292448 4093 5286025 SGTC_522 1273-0010 11.6 µM -0.988326230021077 0.153168502605076 no 2843 0.161496451646562 4178 5705015 SGTC_328 k915-0120 63.5 µM -0.989988058766255 0.152762838064062 no 2844 0.161089977850386 4058 6624543 SGTC_206 4546-0025 72.014 µM -0.991147510651345 0.152480229787059 no 2845 0.160806778276474 4139 6620745 YIL048W NEO1 SGTC_1474 0330-0125 5.35 µM -0.991932241960999 0.152289154022128 no 2846 0.160615289886176 4082 X1474 SGTC_1949 st076024 69.1 µM -0.992675055369518 0.152108431434087 no 2847 0.160434167479712 4012 2921930 SGTC_2814 7977482 42.97 µM -0.992915343691458 0.152050001051271 no 2848 0.160375605840787 4147 6456762 SGTC_2504 purpurogallin 52.29 µM -0.993518193545307 0.15190347300161 no 2849 0.16022874435647 3989 5281571 An antioxidant. SGTC_86 0417-1630 471.922 µM -0.993935701311504 0.15180204900374 no 2850 0.160127085975144 4087 3634867 SGTC_2357 9067248 200 µM -0.995548512284374 0.151410676063184 no 2851 0.159734781046101 4083 9150235 SGTC_928 2764-0428 58.7 µM -0.996310126846626 0.151226092234152 no 2852 0.159549742443557 4115 662578 SGTC_620 0109-0052 432 µM -0.997589894283115 0.150916266829453 no 2853 0.159239131713991 4077 493037 SGTC_1004 4084-0029 199 µM -0.997661392982445 0.150898969816263 no 2854 0.159221790044219 4113 716894 YLR208W SEC13 SGTC_3131 9127911 49.47 µM -1.00650162460779 0.148770501390576 no 2855 0.15708716526565 4163 45595681 SGTC_419 nsc-638432 893 µM -1.00797423781716 0.148417898587804 no 2856 0.156733415021876 4057 368090 SGTC_175 3793-3120 23.7 µM -1.00799276906378 0.148413465026298 no 2857 0.15672896680013 4106 5322297 SGTC_1522 st012842 45.6 µM -1.00976828217043 0.14798908806362 no 2858 0.156303159777139 3943 3491067 YOR116C RPO31 SGTC_2983 9022671 12.99 µM -1.01112340566129 0.147665738218653 no 2859 0.155978684633913 4123 6405161 SGTC_1382 3002-2117 298 µM -1.01530756540205 0.146670332050188 no 2860 0.154979619615409 4181 1497314 SGTC_3185 9108267 49.47 µM -1.01910088600343 0.145771806063023 no 2861 0.154077536797409 4117 4910486 SGTC_3075 9116269 49.47 µM -1.02367619655886 0.144692982175262 no 2862 0.152994121021339 4152 17015205 YNL244C SUI1 SGTC_3220 9131269 49.47 µM -1.02567337485552 0.144223752839027 no 2863 0.152522784237474 4129 17722206 SGTC_1468 k284-1086 134 µM -1.02675879649146 0.14396916794187 no 2864 0.15226702780979 4097 15996457 SGTC_961 1252-1571 372 µM -1.02682673787402 0.143953242423696 no 2865 0.152251028347966 4134 6813498 SGTC_405 ebelactone b 50 µM -1.0269986532529 0.143912950619183 no 2866 0.152210549118204 4082 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_849 0386-0493 241 µM -1.02809245216999 0.143656775164117 no 2867 0.151953170377579 4088 726119 SGTC_1702 st027038 51 µM -1.02872589870443 0.1435085583015 no 2868 0.1518042481286 4142 5521182 SGTC_2354 9060492 162 µM -1.02895425736811 0.143455151168924 no 2869 0.151750585169271 4172 6471895 SGTC_1028 k015-0029 4.8 µM -1.02899321385845 0.143446041602358 no 2870 0.151741431879217 4063 4588309 SGTC_3046 9092212 49.47 µM -1.02981354893942 0.143254305549783 no 2871 0.151548769620758 4176 25236637 SGTC_1444 4112-3581 28 µM -1.03014866093095 0.14317602999639 no 2872 0.151470112693092 4154 2877249 SGTC_3206 9114350 49.47 µM -1.03098087561904 0.142981766035446 no 2873 0.151274894075999 4027 17087243 SGTC_3093 9117344 49.47 µM -1.03326410590812 0.142449706343047 no 2874 0.150740159996477 4158 24824913 SGTC_2958 9077254 16.72 µM -1.03604146563658 0.141804307419893 no 2875 0.150091399046226 4207 16457351 SGTC_1019 4262-0212 3.4 µM -1.0372957119462 0.141513497509825 no 2876 0.149799031798051 4148 4677213 SGTC_274 sirtinol 40.1 µM -1.03907599438214 0.141101415030972 no 2877 0.149384697203505 4191 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.03928963407559 0.141052018530022 no 2878 0.149335027163883 4100 2724278 An inhibitor of dopamine biosynthesis. SGTC_3194 9111903 49.47 µM -1.04143227402839 0.140557258673679 no 2879 0.148837485153644 4176 17087251 SGTC_1357 1503-1303 39.5 µM -1.04616248885734 0.139469173647215 no 2880 0.147743009182727 4095 292895 SGTC_3350 9150499 3.57 µM -1.04643158803568 0.139407445831416 no 2881 0.147680907522388 4121 4910996 YPR165W RHO1 SGTC_2385 9074692 200 µM -1.04664687599314 0.139358074986635 no 2882 0.147631236795966 4148 17046906 SGTC_3330 9141424 71.43 µM -1.04685984297838 0.139309248103082 no 2883 0.147582112569492 4218 27261020 SGTC_2084 5306078 60.6385 µM -1.049180907639 0.13877785295698 no 2884 0.147047432054557 4063 679340 SGTC_1789 tunicamycin 25 nM -1.05234172019788 0.138056424777344 no 2885 0.146321398484773 4045 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2173 5763948 167 µM -1.05625785483626 0.137166154028627 no 2886 0.145425212555528 4122 2867177 SGTC_1210 3013-0140 750 nM -1.056412444568 0.137131091163883 no 2887 0.145389911452584 4182 905973 SGTC_3279 9140807 49.47 µM -1.05924996451822 0.136488594087269 no 2888 0.144742977782051 4191 45595718 SGTC_2961 9083290 32.55 µM -1.05948650671526 0.136435127178426 no 2889 0.144689135581704 4089 17741490 SGTC_2557 derrustone 83.84 µM -1.06176810830618 0.135920140037653 no 2890 0.144170485583363 4147 629853 An antioxidant. SGTC_974 1326-0144 138 µM -1.0622898342089 0.135802566932632 no 2891 0.14405206399266 4176 5411856 SGTC_1301 naphtanilide LB 4.81 µM -1.06513735936676 0.135162092894965 no 2892 0.143406887614726 4216 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_864 0469-0573 172 µM -1.06529838523459 0.135125936440469 no 2893 0.143370461646575 4142 689425 SGTC_3231 9132313 49.47 µM -1.0669851629954 0.134747589039965 no 2894 0.142989267933466 4117 4905967 SGTC_166 k072-0058 166.424 µM -1.06951647518954 0.134181176059574 no 2895 0.142418504569824 4063 5846229 SGTC_1052 3253-3998 198 µM -1.0712508628751 0.133794030450446 no 2896 0.142028323623406 4100 5450317 SGTC_118 0083-0097 135.343 µM -1.07207922974317 0.133609395703703 no 2897 0.141842223538676 4175 5207356 SGTC_2796 7949634 45.45 µM -1.07295963389943 0.133413354502441 no 2898 0.141644613897331 4137 2971588 SGTC_2628 lathosterol 100 µM -1.07391976758395 0.133199785436599 no 2899 0.141429321389171 4232 6710616 SGTC_277 nystatin 15.5 µM -1.07455963491513 0.133057586101597 no 2900 0.141285965989211 4157 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1081 sertraline 6 µM -1.07494895141543 0.132971118458647 no 2901 0.141198792025006 4157 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_878 0828-0289 13.7 µM -1.07570681344943 0.13280290739477 no 2902 0.141029199643997 4107 745350 YLR208W SEC13 SGTC_744 1594-0068 283 µM -1.07573654730444 0.132796310813715 no 2903 0.14102254869736 4139 668392 SGTC_1319 1306-0155 43.7 µM -1.08014953694306 0.131819771650708 no 2904 0.140037797853748 4229 3122360 SGTC_3334 9142812 21.919 µM -1.08168191677378 0.131481836997363 no 2905 0.139696945525044 4169 45283678 SGTC_1238 0333-0287 48.8 µM -1.08222584055312 0.131362029805924 no 2906 0.139576094511167 4144 7226 SGTC_474 dl-dihydrosphingosine 5 µM -1.08342148001647 0.131098937696168 no 2907 0.139310692851733 4204 3058739 A sphingolipid protein kinase C inhibitor. SGTC_814 3342-0569 96 µM -1.08410580343624 0.130948521005134 no 2908 0.139158944996479 4254 4346283 SGTC_1388 3346-4487 254 µM -1.08467953179242 0.130822505431921 no 2909 0.139031808183059 4237 3345614 SGTC_1259 0671-0132 43 µM -1.0856886442612 0.130601064077501 no 2910 0.138808383202196 4109 X1259 SGTC_644 1498-1197 63.3 µM -1.08706438513986 0.130299586886658 no 2911 0.138504178085154 4209 6741615 SGTC_787 4152-0075 138 µM -1.08855187689693 0.129974162909156 no 2912 0.138175774000785 4196 9566539 SGTC_2873 9040596 71.43 µM -1.09155865983235 0.129318077207031 no 2913 0.137513567602249 4169 6463863 SGTC_389 tpck 16.7 µM -1.09289689426565 0.129026811298042 no 2914 0.13721953602717 4203 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2141 5621638 7.665 µM -1.09369679358897 0.128852931076766 no 2915 0.137043990512624 4204 2856238 SGTC_780 0109-0199 192 µM -1.09530603408001 0.128503610785214 no 2916 0.136691292424097 4269 610414 SGTC_2726 cimetidine 79.27 µM -1.0962081955178 0.128308065020219 no 2917 0.136493836946718 4174 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.09635729972635 0.128275766213435 no 2918 0.136461221402759 4280 688801 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.09663913152138 0.128214731509478 no 2919 0.136399587152883 4195 688669 SGTC_3249 9135183 49.47 µM -1.09747988331772 0.128032774521501 no 2920 0.13621583494043 4183 4902779 SGTC_1411 3909-8223 150 µM -1.09778690745566 0.127966372551992 no 2921 0.136148774902814 4222 X1411 SGTC_1402 3909-7673 35.9 µM -1.10083507619504 0.127308424498252 no 2922 0.135484221330695 4196 5328014 SGTC_2570 licareol 100 µM -1.10427363532189 0.126569039413775 no 2923 0.134737227950327 4187 443158 SGTC_1802 st050112 57.9 µM -1.10448845322162 0.126522947111851 no 2924 0.134690654836739 4195 4662563 SGTC_2922 7999257 32.47 µM -1.10522281237452 0.126365467997247 no 2925 0.134531527187558 4165 2988377 SGTC_1921 5740136 50 µM -1.10784384421944 0.12580451660965 no 2926 0.133964630611881 4164 1774243 SGTC_624 k048-0052 28 µM -1.10843829753132 0.125677534137376 no 2927 0.133836286461173 4182 6835531 SGTC_1864 st057645 30.4 µM -1.10883559007902 0.125592717475624 no 2928 0.133750557008616 4241 688666 SGTC_1574 spiramycin 23.7 µM -1.11483884810177 0.124315961838801 no 2929 0.132459742854886 4175 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2592 piperlongumine 83.33 µM -1.1154445670231 0.12418764526286 no 2930 0.132329980205359 4225 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3159 9100096 49.47 µM -1.11574190217278 0.124124691169968 no 2931 0.132266314420567 4142 25236875 SGTC_1496 4469-0713 57.4 µM -1.11681279626797 0.123898138241632 no 2932 0.13203718818473 4195 746691 SGTC_2727 riluzole 51.77 µM -1.11903388081759 0.123429179877918 no 2933 0.131562842611199 4241 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_7 0192-1582 4.227 µM -1.12046948237334 0.123126730269456 no 2934 0.131256875132562 4254 252616 SGTC_2652 actinonin 100 µM -1.12192981120535 0.122819604502361 no 2935 0.13094614211396 4234 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2178 5812956 200 µM -1.12591322776407 0.121984574010937 no 2936 0.13010112488901 4184 5403383 SGTC_1909 st060837 51.5 µM -1.13331223852739 0.120444142948576 no 2937 0.128541577032599 4202 678937 SGTC_540 1187-0821 17.3 µM -1.13338422863013 0.120429222632775 no 2938 0.128526467119799 4160 847520 SGTC_2199 6590217 200 µM -1.13441055081975 0.120216653685296 no 2939 0.128311187694787 4117 703109 SGTC_2175 5807670 165.306 µM -1.13530143617255 0.120032350480076 no 2940 0.128124520343993 4200 241186 SGTC_2847 9005661 71.43 µM -1.1367358041476 0.119736032116113 no 2941 0.12782437347004 4245 2991449 SGTC_1770 st043884 66.3 µM -1.13999519621204 0.119064610750541 no 2942 0.127144151231992 4228 670149 SGTC_575 k072-0246 11.9 µM -1.14022902759437 0.119016544843208 no 2943 0.127095448558735 4313 6796779 SGTC_2933 9026794 32.47 µM -1.14127600505542 0.118801498284133 no 2944 0.126877542071686 4184 17586027 SGTC_1661 st013063 9.66 µM -1.14193656944307 0.118665961298993 no 2945 0.126740193279725 4285 721395 SGTC_2205 7238770 200 µM -1.14550112221097 0.117936458931095 no 2946 0.12600081541819 4295 279867 SGTC_1429 4049-0205 9.46 µM -1.14683224426028 0.117664853886159 no 2947 0.125725480024291 4252 22774478 SGTC_3240 9133527 49.47 µM -1.14806665661675 0.117413377620487 no 2948 0.125470523846817 4188 17617455 SGTC_167 3672-0051 66.205 µM -1.14979906702545 0.117061090706357 no 2949 0.125113319805109 4149 3237971 SGTC_1193 1488-0126 41.5 µM -1.1573505502352 0.115534240167969 no 2950 0.123564584247595 4221 1384710 SGTC_221 trifluoperazine 10.304 µM -1.15782088865656 0.115439611724293 no 2951 0.1234685685589 4218 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_964 1287-0107 19.4 µM -1.15895823839344 0.115211013433114 no 2952 0.123236604060125 4272 51516812 YPR165W RHO1 SGTC_2109 5483026 200 µM -1.16030322927899 0.114941096448583 no 2953 0.122962685102152 4259 759335 SGTC_1018 4259-0013 28.1 µM -1.16102006891041 0.114797422701499 no 2954 0.122816869052724 4298 6801262 SGTC_2238 6671620 73.2395 µM -1.16277500072866 0.114446227038496 no 2955 0.12246040127306 4168 729941 SGTC_2390 9097792 176.6 µM -1.16349831298839 0.11430170113046 no 2956 0.122313691095909 4269 4497149 SGTC_138 0850-0259 40.9225 µM -1.16377211985003 0.11424702536974 no 2957 0.122258186768847 4202 6813004 SGTC_1848 st056003 16.4 µM -1.16393718228015 0.114214073493728 no 2958 0.122224734941661 4264 146492 SGTC_2679 rapamycin 1 nM -1.16503003454597 0.113996075083891 no 2959 0.122003417786831 4161 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_672 1441-0018 53.7 µM -1.16612981418339 0.113776994257145 no 2960 0.121780982032812 4256 251141 SGTC_3016 9080866 49.47 µM -1.1678815130952 0.113428668227218 no 2961 0.121427281074246 4227 17066299 SGTC_424 splitomicin 100 mM -1.17057469320188 0.11289461289763 no 2962 0.120884887239856 4309 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1578 josamycin 24.2 µM -1.1728586860785 0.112443107621061 no 2963 0.120426239713139 4272 5282165 A P450 substrate. SGTC_1849 st056239 19.2 µM -1.17383020316268 0.112251447342571 no 2964 0.120231521832938 4252 5393181 SGTC_505 gw-5074 63.9 µM -1.17399982517545 0.112218008372751 no 2965 0.120197547825532 4289 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1939 st074455 53.6 µM -1.1766209159828 0.1117021961413 no 2966 0.119673422833043 4262 1644229 SGTC_1024 4507-0395 26 µM -1.18090853227212 0.110862083837336 no 2967 0.118819530730918 4310 4201836 SGTC_2161 5662504 8.5105 µM -1.18485546522617 0.110092734980707 no 2968 0.118037299097269 4242 2859334 SGTC_124 0136-0217 7.121 µM -1.18488278496552 0.110087423110626 no 2969 0.11803189739824 4315 3976905 SGTC_1966 st070145 16.1 µM -1.18554720276271 0.109958294699084 no 2970 0.117900581566926 4257 3748532 SGTC_3065 9113888 49.47 µM -1.18586113856523 0.109897319660041 no 2971 0.117838571124771 4326 16648368 SGTC_2262 9014885 67.46 µM -1.18628386691994 0.109815252431485 no 2972 0.117755107803907 4264 6457424 SGTC_2399 5884133 200 µM -1.18702001658422 0.109672443533933 no 2973 0.117609862580941 4253 722445 SGTC_456 gingerol 170 µM -1.18884038074387 0.109319875736792 no 2974 0.117251242236368 4325 442793 A herb. SGTC_3353 9151644 39.2805 µM -1.18909528435613 0.109270571114936 no 2975 0.117201086911026 4291 4909158 SGTC_3031 9088762 49.47 µM -1.19513197653659 0.108107592422261 no 2976 0.116017735180069 4245 205253 SGTC_2886 9058944 51.95 µM -1.19604174605897 0.107933099384451 no 2977 0.115840134296522 4159 4949929 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.19658435455988 0.10782912413217 no 2978 0.115734300798898 4316 688664 SGTC_303 1348-1668 34.2 µM -1.1966728924966 0.107812165241596 no 2979 0.115717038367248 4295 5380509 SGTC_330 1488-0319 80.1 µM -1.19956097321208 0.107260024409176 no 2980 0.11515494555987 4322 6846614 SGTC_1705 st027868 56.3335 µM -1.20156435242083 0.106878219547158 no 2981 0.11476617986899 4214 292948 SGTC_664 1222-0054 14.9 µM -1.20342294199165 0.106524886451062 no 2982 0.114406347158992 4259 6813991 SGTC_2890 9046729 58.44 µM -1.20365250866062 0.106481302528157 no 2983 0.114361957638192 4250 903329 SGTC_93 0109-0045 59.227 µM -1.20508205585259 0.106210188375826 no 2984 0.114085813145213 4414 88733 SGTC_979 1426-2828 121 µM -1.20525859798393 0.106176741716975 no 2985 0.11405174362118 4381 747872 SGTC_1075 aripiprazole 15.2 µM -1.20543209326928 0.106143879709373 no 2986 0.114018269146736 4346 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1695 st026914 34.495 µM -1.20730342845629 0.105789894196277 no 2987 0.113657655409759 4285 3289191 SGTC_1155 4088-0394 48.2 µM -1.20801192481255 0.105656096555186 no 2988 0.113521337754776 4267 2326248 SGTC_2974 9094440 9.66 µM -1.21210411162797 0.104885691813715 no 2989 0.112736265021898 4291 25236134 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.21688083847447 0.103991568328264 no 2990 0.111824778540198 4319 4174840 SGTC_1190 1486-1332 13 µM -1.21738265325832 0.103897958783889 no 2991 0.111729329955386 4291 4150046 SGTC_338 4055-0136 114 µM -1.22141876775386 0.103147275622488 no 2992 0.110963752417441 4289 2900563 SGTC_813 k007-0158 173 µM -1.22155173555713 0.103122611931474 no 2993 0.110938594934734 4303 6523916 SGTC_581 0958-0271 211 µM -1.22231288778525 0.102981511133926 no 2994 0.110794663711889 4307 4591145 SGTC_3321 9137793 26.8275 µM -1.2249179644895 0.102499649007868 no 2995 0.110303065544114 4273 4904192 SGTC_1338 1486-1223 76 µM -1.22496016138165 0.102491857345479 no 2996 0.110295115557973 4313 3444526 SGTC_937 3122-0005 46.7 µM -1.22747944467223 0.102027451348988 no 2997 0.109821221481738 4318 759535 SGTC_377 3970-0964 33.1 µM -1.22877784997339 0.101788701435533 no 2998 0.109577554219728 4267 16481235 SGTC_621 3584-0052 32.1 µM -1.2296483475947 0.101628862801662 no 2999 0.1094144084509 4334 2273927 SGTC_1399 3562-5772 25 µM -1.23381713030315 0.100865934231769 no 3000 0.10863552733199 4296 23847490 SGTC_3008 9078912 71.4286 µM -1.23383076511911 0.100863445795551 no 3001 0.108632986409454 4323 16648731 SGTC_1836 st055642 81 µM -1.23764367840849 0.100169321490695 no 3002 0.107924105626489 4314 8571 SGTC_2189 6047310 154.431 µM -1.23851916123794 0.100010437080187 no 3003 0.107761810860987 4292 711535 SGTC_2823 7987624 58.44 µM -1.24071985097655 0.0996118642714832 no 3004 0.107354629201819 4305 2239440 SGTC_705 1124-0212 310 µM -1.2421842737248 0.0993472827038624 no 3005 0.107084290312145 4310 9554485 SGTC_2657 nystatin 74.44 µM -1.24319658708751 0.0991646856378079 no 3006 0.106897700034205 4361 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_908 3448-7491 47.7 µM -1.24421572799119 0.0989811050884276 no 3007 0.106710088355586 4322 1203031 SGTC_1020 4335-0961 93.3 µM -1.24637338983446 0.0985932603577011 no 3008 0.106313672920915 4283 669075 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.24646693325458 0.0985764709070858 no 3009 0.106296510784737 4349 165521 SGTC_2212 7123476 200 µM -1.24683687040586 0.0985100939949716 no 3010 0.106228659106696 4322 1085715 SGTC_2863 9028737 58.44 µM -1.24728218089876 0.0984302364401693 no 3011 0.10614702439852 4311 6460917 SGTC_2776 terbinafine 19.92 µM -1.24960146997807 0.098015084482077 no 3012 0.105722582942855 4333 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1162 k048-0130 20.1 µM -1.24995686476643 0.0979515824735649 no 3013 0.105657652490219 4279 6797406 SGTC_2113 5491891 107.031 µM -1.25495926640055 0.0970609492610117 no 3014 0.104746773679462 4320 789979 SGTC_2825 7998094 58.44 µM -1.2566650971849 0.0967586043966755 no 3015 0.104437465862209 4319 2987815 SGTC_1511 0906-3109 28.5 µM -1.25825360683371 0.096477676219563 no 3016 0.104150026752705 4333 2882180 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.25995046175098 0.0961782496556377 no 3017 0.103843616671764 4362 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1805 st050013 60.3 µM -1.26187017507548 0.0958403218235112 no 3018 0.10349775279235 4289 4037144 SGTC_2346 9031566 143.75 µM -1.2624046966365 0.0957463854254228 no 3019 0.103401600040821 4304 4771086 SGTC_1473 k844-0725 134 µM -1.26511172066738 0.0952716951410657 no 3020 0.102915640966555 4378 54682906 SGTC_2088 5278280 127.392 µM -1.26549362971837 0.0952048651870971 no 3021 0.102847215263182 4379 791502 SGTC_2032 5185112 25.99 µM -1.26641197619365 0.0950443058030656 no 3022 0.1026828127151 4213 5718189 SGTC_1339 1486-1321 22.7 µM -1.26789468137151 0.0947854977003665 no 3023 0.102417781857187 4368 3469382 SGTC_2999 9069765 71.4286 µM -1.27014633420382 0.094393462526628 no 3024 0.102016254813076 4294 2097066 SGTC_1229 0139-0193 12.2 µM -1.27284439895202 0.0939252789518617 no 3025 0.10153663129668 4416 3090752 SGTC_2474 5321570 43.32 µM -1.2730178493189 0.093895239588625 no 3026 0.101505854035843 4326 2841384 SGTC_592 k241-0073 46.5 µM -1.27416705358572 0.0936963913569291 no 3027 0.101302109349031 4377 4230158 SGTC_899 1083-0020 478 µM -1.27462624070377 0.0936170246385096 no 3028 0.101220782528602 4405 767123 SGTC_2424 5537928 59.2 µM -1.27628905399409 0.0933300363937409 no 3029 0.100926679061601 4355 5382802 SGTC_60 0986-0278 202 µM -1.27683137191152 0.0932365773712684 no 3030 0.100830893603522 4299 3110598 SGTC_373 0844-0104 25.9 µM -1.27744350215883 0.0931311705118037 no 3031 0.100722857383403 4369 5375804 SGTC_2195 6536160 144.242 µM -1.28204722192354 0.092341245259788 no 3032 0.0999130407574257 4326 3834386 SGTC_1206 3978-0017 132 µM -1.28249408074413 0.0922648361782922 no 3033 0.0998346900366939 4419 3873677 SGTC_2832 7992762 51.95 µM -1.2835775711756 0.0920797627836386 no 3034 0.099644900829043 4297 2985177 SGTC_3269 9137823 49.47 µM -1.28373471181289 0.0920529440827538 no 3035 0.0996173972510259 4277 17682936 SGTC_2400 5203494 178.7 µM -1.28382745681912 0.0920371182970143 no 3036 0.0996011671372822 4265 6777674 SGTC_2488 5268135 45.7 µM -1.28518446734234 0.0918057916079537 no 3037 0.0993639150707232 4390 1270356 YLR208W SEC13 SGTC_165 k038-0023 64.381 µM -1.28590678233221 0.0916828358832427 no 3038 0.0992377982000548 4355 46368543 SGTC_2701 st077767 14.721 µM -1.28631176065381 0.0916139520428118 no 3039 0.0991671398365931 4331 5721188 SGTC_976 1348-1067 47.6 µM -1.28818667217744 0.0912955430611459 no 3040 0.0988404951351238 4381 5310671 YGL099W LSG1 SGTC_731 3966-0296 387 µM -1.29008441778874 0.0909740925201621 no 3041 0.0985106747298872 4363 660956 SGTC_2210 7115885 190.385 µM -1.29360953869206 0.0903792178252576 no 3042 0.0979001629926405 4451 2927039 SGTC_2406 ethylparaben 405.7 µM -1.30093411750047 0.0891524179904163 no 3043 0.0966405033644977 4348 8434 A possible steroid mimic. SGTC_2382 9035899 200 µM -1.30343064057508 0.0887371177044077 no 3044 0.0962138907199015 4357 6462679 SGTC_2910 7948405 25.97 µM -1.30534039266157 0.0884204014881664 no 3045 0.0958884828107683 4314 2971328 SGTC_1406 3909-7906 11.9 µM -1.30951608490669 0.0877308337876013 no 3046 0.0951797964124927 4395 X1406 SGTC_919 tnp00227 403.569 nM -1.31003531797627 0.0876453696202229 no 3047 0.0950919440121475 4323 1269246 A methoxyflavone. YNL221C POP1 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.31011501948237 0.0876322564985543 no 3048 0.0950784640880348 4351 6312947 SGTC_3097 9117246 49.47 µM -1.31069671310463 0.0875365959931525 no 3049 0.0949801248025105 4398 16423892 SGTC_3233 9132340 49.47 µM -1.31139999492318 0.0874210441913771 no 3050 0.0948613302823017 4374 17682950 SGTC_3308 9128332 17.569 µM -1.31509607333195 0.0868156357482558 no 3051 0.0942388080596658 4368 17332805 YDL196W YDL196W SGTC_120 rhodamine 6G 52.259 µM -1.31575480988067 0.0867080660494937 no 3052 0.0941281756463568 4393 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_518 1021-0119 62.6 µM -1.31581134942695 0.0866988379551772 no 3053 0.0941186845015542 4351 1097762 SGTC_2853 9015042 58.44 µM -1.31766726466062 0.0863963323317028 no 3054 0.0938075287450623 4303 6457456 SGTC_3035 9091303 49.47 µM -1.31794210899665 0.0863516011479315 no 3055 0.0937615140060072 4451 25237002 SGTC_1242 0402-0103 60.1 µM -1.31826537596801 0.0862990112997419 no 3056 0.0937074136238038 4305 432868 SGTC_2993 9054257 71.4286 µM -1.31972916195829 0.0860611788384229 no 3057 0.0934627299773028 4299 6470217 YGL055W OLE1 SGTC_3273 9137859 49.47 µM -1.32449167350516 0.0852907704982801 no 3058 0.0926699032941423 4466 2377234 SGTC_1481 3346-2004 36 µM -1.32646073735254 0.0849737586550411 no 3059 0.0923435659945162 4463 2770522 SGTC_2866 9034245 58.44 µM -1.32773738685084 0.0847686953786452 no 3060 0.0921324389827692 4399 6462273 SGTC_1441 4106-0040 13 µM -1.33637503542915 0.0833910019585802 no 3061 0.0907133609475845 4412 2904180 SGTC_49 0717-0965 32.132 µM -1.34076237879351 0.0826977042943198 no 3062 0.0899988072299387 4460 5889349 YGL099W LSG1 SGTC_2691 st077356 60.2 µM -1.3437167938738 0.0822332909495791 no 3063 0.0895199922916413 4403 2839272 SGTC_2614 arthonioic acid 13.39 µM -1.34543133229045 0.0819646797780279 no 3064 0.0892429913131186 4253 6710684 SGTC_1025 k007-0731 70 µM -1.34728089025888 0.0816756573930338 no 3065 0.0889448921638046 4359 6256118 SGTC_3352 9151559 45.5865 µM -1.34768859881913 0.0816120500238204 no 3066 0.0888792803013231 4416 17159339 SGTC_1483 3453-0561 55.9 µM -1.34785543104397 0.0815860329898804 no 3067 0.088852442659938 4434 4546991 SGTC_2951 9072950 58.06 µM -1.35137669609026 0.081038359193899 no 3068 0.088287397462251 4325 16488155 SGTC_1667 st014849 34.6 µM -1.35386460172162 0.0806530831040923 no 3069 0.0878897893433106 4483 5348460 SGTC_423 5-fluorouracil 457 µM -1.36223149341081 0.0793675362243476 no 3070 0.0865624198861292 4339 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_158 k038-0087 26.446 µM -1.36396400494021 0.0791032901872912 no 3071 0.0862894473409496 4321 X158 SGTC_2659 sanguinarine 24.21 µM -1.36909808082465 0.0783241433030413 no 3072 0.0854843090795556 4366 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1192 1488-0095 21.4 µM -1.37681790558833 0.0771635566312045 no 3073 0.0842842767429196 4445 915875 SGTC_2087 5276107 200 µM -1.37683161227096 0.0771615076743953 no 3074 0.084282157366813 4385 144405 SGTC_3091 9116372 49.47 µM -1.3781522450698 0.0769642854094456 no 3075 0.0840781439380381 4473 17169793 SGTC_1866 st057638 64 µM -1.37823074181427 0.0769525748425612 no 3076 0.0840660293212458 4420 688802 SGTC_2743 auranofin 4.32 µM -1.38203057424115 0.0763873135887119 no 3077 0.0834811567824747 4453 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1721 st082152 9.2685 µM -1.382066903354 0.0763819245752153 no 3078 0.0834755797794744 4355 5296051 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.38216017549288 0.0763680900318065 no 3079 0.0834612625453689 4381 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2433 5607874 27.82 µM -1.38598949887125 0.0758017520438775 no 3080 0.0828750550281998 4393 2252428 SGTC_756 0508-1999 28.3 µM -1.38983885687865 0.0752356806880336 no 3081 0.0822889079069774 4443 6753853 SGTC_185 k048-0037 25.491 µM -1.39150842777122 0.0749911646016955 no 3082 0.0820356529016317 4465 6827589 SGTC_1884 5633444 25 µM -1.39208657547813 0.0749066337306482 no 3083 0.0819480914613686 4381 5724239 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.39366573841262 0.0746761150160441 no 3084 0.0817092834886579 4415 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1992 st073643 23.3 µM -1.39377577943609 0.0746600719482861 no 3085 0.081692662173335 4425 3161292 SGTC_3204 9114183 49.47 µM -1.39411004610876 0.0746113547724521 no 3086 0.0816421879819125 4397 17027248 SGTC_2626 ethyl orsellinate 100 µM -1.39647211251782 0.0742677902991067 no 3087 0.0812861863905809 4368 75653 A natural product. SGTC_3282 9108498 15.4605 µM -1.39878540653607 0.073932492092231 no 3088 0.0809386718962857 4394 16459645 SGTC_2976 9009005 19.48 µM -1.39997481503179 0.0737605452843959 no 3089 0.0807604301817129 4437 2993148 SGTC_2850 9015429 58.44 µM -1.40065800286695 0.0736619185572635 no 3090 0.0806581835043121 4426 6457570 SGTC_881 0833-0569 170 µM -1.40390351632823 0.0731947645927241 no 3091 0.0801737912241198 4459 5418700 SGTC_2882 9058044 58.44 µM -1.40603923477126 0.072888591539632 no 3092 0.079856237267765 4457 18076804 SGTC_2290 7904846 200 µM -1.40848417873047 0.0725392931325461 no 3093 0.0794938742805954 4477 2962154 SGTC_3198 9112019 49.47 µM -1.40947894899262 0.0723975421984579 no 3094 0.0793467969066087 4488 45595555 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.4100777578406 0.0723123166274001 no 3095 0.079258362031444 4383 6708514 SGTC_2475 5812728 15.03 µM -1.41149185197892 0.0721113605999869 no 3096 0.0790498182323941 4387 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1246 0422-0085 105 µM -1.41272485395009 0.0719364890776778 no 3097 0.0788683204144379 4448 264295 SGTC_2729 fluphenazine 10.66 µM -1.41843723850128 0.0711305656899212 no 3098 0.078031575043724 4384 3372 An atypical antipsychotic. SGTC_262 fenpropimorph 62.5 µM -1.41903522592732 0.0710466019919931 no 3099 0.077944373244794 4467 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1231 0242-0792 125 µM -1.42136386387991 0.0707203620229931 no 3100 0.077605503049667 4435 3707635 SGTC_2094 5332512 191.667 µM -1.42218872390587 0.0706050764267055 no 3101 0.077485735678555 4481 755774 SGTC_807 1315-0151 48 µM -1.43440248750234 0.0689148916322527 no 3102 0.0757287191049938 4468 4011080 SGTC_2236 dapsone 200 µM -1.43549882377784 0.068764715322023 no 3103 0.0755725016359329 4479 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_3122 9126309 49.47 µM -1.44092325398515 0.0680253863246627 no 3104 0.0748031828554985 4552 17591206 SGTC_1368 1852-0141 284 µM -1.44226612643952 0.0678433091083694 no 3105 0.0746136561115243 4442 2838987 SGTC_2101 5377231 179.231 µM -1.44292208435919 0.0677545061128221 no 3106 0.0745212106144769 4488 2844213 SGTC_791 1348-1292 225 µM -1.44362500242416 0.0676594453814049 no 3107 0.0744222440002682 4423 5437054 SGTC_194 1486-1323 56.904 µM -1.44712875588199 0.0671871433905596 no 3108 0.0739304327762394 4542 5178754 SGTC_1891 st059073 26.2 µM -1.45005026190104 0.066795280089027 no 3109 0.0735222518196854 4536 688754 SGTC_2646 retinol 96.75 µM -1.45203125350115 0.0665305762201097 no 3110 0.0732464576532315 4462 445354 A vitamin A analog and teratogen. SGTC_2445 5742597 35.57 µM -1.4521567222152 0.0665138382350417 no 3111 0.07322901655428 4478 1774255 SGTC_2105 5350118 200 µM -1.45899866860034 0.0656060239544115 no 3112 0.0722827370688912 4439 2133313 SGTC_1901 st060216 58.6 µM -1.45902009465905 0.065603196233345 no 3113 0.0722797885140757 4430 688792 SGTC_441 propafenone 146 µM -1.45948209055017 0.0655422469442455 no 3114 0.0722162332010149 4453 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2619 obliquin 87.91 µM -1.4601704838746 0.0654515114090016 no 3115 0.0721216125773183 4447 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2024 5144227 134 µM -1.46135625630744 0.0652954459543459 no 3116 0.0719588493738989 4443 3475211 SGTC_2737 bleomycin 30.5 nM -1.46309051055017 0.0650677121341876 no 3117 0.0717213070611403 4562 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_3141 9094609 49.47 µM -1.46598536258156 0.0646889481455045 no 3118 0.0713261372952424 4443 25236309 YDL196W YDL196W SGTC_2921 7974240 10.71 µM -1.46962742258279 0.0642148539955407 no 3119 0.0708313445211323 4545 2979074 YDR527W RBA50 SGTC_2787 5284540 71.43 µM -1.47145449141717 0.0639780402794732 no 3120 0.0705841230677785 4483 736958 SGTC_1459 k035-0031 35.7 µM -1.47540620031141 0.063468166689122 no 3121 0.070051684709141 4206 3877128 YMR208W ERG12 SGTC_1521 st012942 49.4 µM -1.48017401126436 0.0628572107596708 no 3122 0.0694134070771445 4413 24207259 SGTC_3044 9093193 49.47 µM -1.48101122880599 0.0627504027237772 no 3123 0.0693017906549454 4475 25236277 SGTC_1038 k292-0204 154 µM -1.48384463851579 0.0623899794977437 no 3124 0.0689250708500627 4426 4454212 SGTC_2066 5222451 176 µM -1.48423505335679 0.0623404436646205 no 3125 0.0688732866952437 4427 2281147 SGTC_879 0831-1030 162 µM -1.485886384517 0.0621312619318183 no 3126 0.0686545877861156 4489 1549252 SGTC_1863 st057641 20.1 µM -1.4889500020869 0.0617446301394806 no 3127 0.0682502675574793 4531 3921635 SGTC_3297 9117502 71.43 µM -1.49031957870127 0.061572396785579 no 3128 0.0680701134588483 4512 7453720 SGTC_2642 cholecalciferol 100 µM -1.49341257235882 0.0611848128007175 no 3129 0.0676646119948922 4491 9821465 A vitamin D precursor, similar to steriods. SGTC_1096 rimcazole 32.2 µM -1.4981638818794 0.0605931418653699 no 3130 0.0670453385250489 4443 18528119 A dopamine reuptake inhibitor. SGTC_3011 9081274 71.4286 µM -1.50098116684966 0.0602444306534378 no 3131 0.0666802163858648 4496 6625322 SGTC_3085 9117376 49.47 µM -1.50402004240457 0.0598700550797264 no 3132 0.0662881031128069 4560 16480349 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.50525385050077 0.0597185766940526 no 3133 0.0661294125666215 4497 688662 SGTC_2298 7976326 193.81 µM -1.50852658500467 0.0593182276129476 no 3134 0.0657099039256838 4451 2235818 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.51387464351354 0.0586685397034083 no 3135 0.0650288181682665 4498 115019 SGTC_913 3487-1245 167 µM -1.51762156092782 0.0582166973112311 no 3136 0.06455491414001 4443 4016153 SGTC_2140 5586273 200 µM -1.51856446892371 0.0581034232802169 no 3137 0.0644360802035377 4476 854421 SGTC_2307 7538926 6.34 µM -1.51906949392891 0.0580428245506053 no 3138 0.064372502240802 4459 96582 SGTC_3128 9127691 49.47 µM -1.52342924195324 0.0575217546339161 no 3139 0.0638256753785287 4508 41316314 SGTC_902 1120-0002 2.07 µM -1.52696699878771 0.0571016379917564 no 3140 0.063384608882857 4491 3280475 SGTC_198 3454-2873 16.191 µM -1.52837284504925 0.0569353627000433 no 3141 0.0632099964928208 4508 710957 SGTC_2903 5923464 63.88 µM -1.5293124924146 0.0568244394301282 no 3142 0.06309349708094 4529 2876576 SGTC_3117 9124945 49.47 µM -1.52936756930702 0.0568179430103104 no 3143 0.0630866737261552 4426 17592065 SGTC_3270 9137563 49.47 µM -1.5337344639187 0.0563047190459704 no 3144 0.0625474957582394 4515 17015724 SGTC_1665 st014639 11.4 µM -1.53405685079005 0.0562669755111367 no 3145 0.062507833668343 4600 981133 YIL048W NEO1 SGTC_416 estradiol valerate 100 µM -1.53467198089341 0.0561950143205869 no 3146 0.062432210839725 4502 13791 A steroid. SGTC_253 dyclonine 31.25 µM -1.53814165478668 0.0557904715241617 no 3147 0.0620069915192697 4604 3180 An oral anasthetic. SGTC_2378 9074213 121.43 µM -1.53895363486976 0.055696132206886 no 3148 0.0619078078984183 4489 657714 SGTC_504 lovastatin 124 µM -1.54045670651626 0.05552183117708 no 3149 0.0617245340182249 4514 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_3255 9139072 49.47 µM -1.54105195048274 0.0554529239163216 no 3150 0.0616520713950945 4511 17646060 SGTC_2127 5253358 187.912 µM -1.54221039263714 0.0553190126975007 no 3151 0.0615112377149953 4447 20612 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.54403619275896 0.0551084761814595 no 3152 0.0612897824725711 4591 688664 SGTC_708 3448-5400 146 µM -1.54543590250849 0.0549475020341709 no 3153 0.0611204308731192 4478 3462195 SGTC_510 ag-490 170 µM -1.54845410415535 0.0546016572037033 no 3154 0.0607565017886744 4645 5328779 SGTC_1116 jasmonic acid  1.58368 µM -1.55219725843232 0.0541751363347372 no 3155 0.0603075159481585 4559 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_676 falcarinol 140 µM -1.55377584645984 0.0539960534093098 no 3156 0.0601189469325653 4536 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2405 ticlatone 3.52 µM -1.55601774370824 0.0537425270990823 no 3157 0.0598519365578484 4337 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1771 st048882 4.1505 µM -1.55703147928575 0.0536281981547 no 3158 0.0597315058591356 4548 4580403 SGTC_1400 3771-8998 51.5 µM -1.55895045043476 0.0534123044921308 no 3159 0.0595040540872939 4477 670767 SGTC_272 doxorubicin 8.13 µM -1.56261817329184 0.0530015843684496 no 3160 0.0590712155734511 4566 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3247 9135149 49.47 µM -1.56303327621527 0.0529552583845493 no 3161 0.0590223840609743 4571 8934436 YOR116C RPO31 SGTC_2505 galangin 7.89 µM -1.56441512450347 0.052801273817865 no 3162 0.0588600555519074 4445 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1374 2889-5571 141 µM -1.56567767962323 0.0526608932881409 no 3163 0.058712047117383 4516 2853281 SGTC_2664 lyso-paf C-16 73.48 µM -1.56587624714835 0.0526388420102347 no 3164 0.058688795796587 4505 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_630 4356-0227 183 µM -1.57175565822208 0.0519892372635646 no 3165 0.0580036143402145 4481 779312 SGTC_1107 amlodipine 47 µM -1.57416189509012 0.0517252205127319 no 3166 0.0577250131017921 4120 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_51 1013-0126 23.419 µM -1.57465925684848 0.0516707822018528 no 3167 0.0576675585175463 4523 1627850 SGTC_968 1309-0633 340 µM -1.57952486097282 0.0511406207747995 no 3168 0.0571078593619337 4564 3761976 SGTC_612 0302-0167 22.4 µM -1.58959330625513 0.0500573021426866 no 3169 0.0559632534370317 4539 235821 SGTC_2874 9043904 71.43 µM -1.59019422839408 0.0499932287512782 no 3170 0.0558955155423338 4460 4463428 SGTC_834 0312-0008 75.7 µM -1.59276056165025 0.0497203289072077 no 3171 0.0556069578185045 4569 6385573 YIL048W NEO1 SGTC_399 oxolinic acid 75 µM -1.59315380639343 0.049678617090737 no 3172 0.0555628455758179 4518 4628 A DNA gyrase inhibitor. SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.59376324785453 0.0496140282689217 no 3173 0.0554945360414712 4550 688667 SGTC_2902 5787006 60.46 µM -1.59620449624991 0.0493559754635989 no 3174 0.0552215720467442 4518 591003 SGTC_2022 5136654 200 µM -1.61628069263166 0.0472742407664515 no 3175 0.0530168196339748 4538 1713771 SGTC_767 0929-0023 86 µM -1.62152322107334 0.0467423838737065 no 3176 0.0524527370095593 4581 1204563 SGTC_2146 5545642 200 µM -1.62162366896638 0.0467322404535982 no 3177 0.0524419757741354 4509 825326 SGTC_2888 9058547 12.99 µM -1.62391535880863 0.0465013006108935 no 3178 0.0521969370824268 4486 16476514 SGTC_3196 9111891 49.47 µM -1.62963957543876 0.0459284559069907 no 3179 0.0515888474841397 4534 18891510 SGTC_3275 9138069 49.47 µM -1.63227909399833 0.0456662259125244 no 3180 0.0513103526281863 4589 17617007 SGTC_1151 3909-8316 15.3 µM -1.6355840155142 0.0453395881086895 no 3181 0.0509633389946878 4592 800431 SGTC_2855 9016525 58.44 µM -1.63598260284451 0.0453003215375415 no 3182 0.0509216142403288 4503 43811474 SGTC_232 clozapine 119 µM -1.63670496379462 0.0452292283366979 no 3183 0.0508460656553051 4605 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.63871101756469 0.0450322675623716 no 3184 0.050636729200274 4461 4330530 SGTC_438 sphingosine 6.67 µM -1.64014442147771 0.0448919546914406 no 3185 0.0504875710370718 4498 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2366 9070441 60.58 µM -1.64230300934156 0.0446813194213022 no 3186 0.0502636118860454 4532 6837235 SGTC_1017 4239-0030 168 µM -1.64388639514105 0.0445273190823359 no 3187 0.0500998354523843 4577 1149593 SGTC_727 3032-0951 202 µM -1.64842746350882 0.0440880247166369 no 3188 0.0496324921060202 4592 3652836 SGTC_1325 1431-0015 227 µM -1.65040699296412 0.0438976255963844 no 3189 0.0494298609019796 4567 1103340 SGTC_3078 9116413 49.47 µM -1.65431570931814 0.0435236173627666 no 3190 0.049031691378983 4523 17177322 SGTC_1668 st014914 51.6 µM -1.65488886341432 0.0434689915767722 no 3191 0.0489735218455647 4595 2839556 SGTC_826 1683-5028 118 µM -1.65965906395754 0.0430165005838488 no 3192 0.0484915294905401 4607 722377 SGTC_2053 5265679 138 µM -1.67054527391876 0.0419981045320342 no 3193 0.0474057648788282 4498 764595 SGTC_2807 7945238 51.95 µM -1.67396265850257 0.041682466273593 no 3194 0.0470689691929582 4552 17148797 SGTC_91 0417-1751 58.384 µM -1.67821707518795 0.0412922055998048 no 3195 0.0466523647669807 4653 6795624 SGTC_1694 st024011 44.9 µM -1.68557234283508 0.0406244921035427 no 3196 0.0459390999917639 4620 2787533 SGTC_1950 st077106 7.18 µM -1.68834051074694 0.0403754778301414 no 3197 0.0456729414800806 4487 13831864 SGTC_1504 k297-0033 30 µM -1.69533542754976 0.0397517608053297 no 3198 0.0450059038909907 4496 4388117 SGTC_683 panaxydol 45 µM -1.70530585376084 0.0388762895235148 no 3199 0.0440686982078066 4605 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1169 aniline yellow 25.8 µM -1.71846557379856 0.0377448840221025 no 3200 0.0428558642919586 4544 6051 A DNA damaging agent. SGTC_1781 st038725 66.3 µM -1.7211002623122 0.0375216277135379 no 3201 0.0426163158562367 4595 4270275 YIL048W NEO1 SGTC_1303 1160-0052 261 µM -1.72128692492697 0.0375058514252112 no 3202 0.0425993854606058 4559 3562476 SGTC_2827 7993847 71.43 µM -1.72238872311684 0.037412840331621 no 3203 0.0424995625559834 4620 2985692 SGTC_1671 st016596 74.5 µM -1.73199735525118 0.0366096638210597 no 3204 0.0416370166664854 4643 2829167 SGTC_1910 st062352 60.4 µM -1.73313591269725 0.0365154346613959 no 3205 0.0415357572862244 4524 2245730 SGTC_1610 st001799 48.1 µM -1.73764452018863 0.0361442407865476 no 3206 0.041136735030739 4572 621897 SGTC_371 0195-0006 7.36 µM -1.7382960042832 0.0360908604484443 no 3207 0.0410793350384473 4452 3928593 SGTC_2026 5148700 152 µM -1.73987648272473 0.0359616298023001 no 3208 0.0409403544756163 4597 79838 SGTC_3138 9097216 49.47 µM -1.74145535590987 0.0358329091229571 no 3209 0.0408018961400781 4540 25237486 SGTC_1436 4092-1007 8.32 µM -1.74207771256702 0.0357822741364386 no 3210 0.0407474234486214 4614 2881121 SGTC_2204 7233102 200 µM -1.74552541705018 0.0355028296760852 no 3211 0.0404467260465857 4611 2172480 SGTC_2927 9011802 47.9 µM -1.75410531444303 0.0348151696972915 no 3212 0.0397062316123408 4570 43912568 SGTC_529 4076-0302 30.3 µM -1.75700315170056 0.0345853995793604 no 3213 0.039458635998212 4598 5816522 SGTC_614 0462-0418 107 µM -1.76037020883469 0.0343199909006022 no 3214 0.0391725285527598 4390 5188303 SGTC_2760 etidronate 98.04 µM -1.76323496436009 0.0340954962561383 no 3215 0.0389304344988353 4570 3305 A chelator and antioxidant. SGTC_2713 st079149 53.4 µM -1.76583768268126 0.0338925841217792 no 3216 0.0387115422638868 4632 3103253 SGTC_403 arphamenine a 50 µM -1.76691603980607 0.0338088051906222 no 3217 0.0386211451859869 4624 5487158 An arginine aminopeptidase inhibitor. SGTC_3232 9132874 49.47 µM -1.76928152565374 0.0336256243057846 no 3218 0.0384234524430588 4591 3784940 SGTC_1315 1237-0019 3.69 µM -1.7762389399661 0.0330915783566461 no 3219 0.0378467712756572 4627 825140 SGTC_1362 1611-0397 101 µM -1.77641805109996 0.0330779227260347 no 3220 0.0378320190128688 4626 27816 SGTC_2011 4012611 177 µM -1.77905342410196 0.0328775351731461 no 3221 0.0376155018273172 4591 2049887 SGTC_2443 5493264 126.67 µM -1.78464180726967 0.0324559175404796 no 3222 0.0371597177776786 4636 5340055 SGTC_670 4204-0025 119 µM -1.78567032680562 0.0323788086170198 no 3223 0.0370763262952615 4634 719039 SGTC_1078 idebenone 36.1 µM -1.78636926104009 0.0323264952759123 no 3224 0.0370197446404987 4641 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_278 4092-0821 23.9 µM -1.79051641156854 0.0320175251601474 no 3225 0.0366854656615404 4602 877900 SGTC_2900 5328528 85.29 µM -1.79409170239639 0.031753120685009 no 3226 0.036399266616322 4609 795359 SGTC_948 3448-0295 75.3 µM -1.79502318396765 0.0316845315767692 no 3227 0.0363250031040537 4603 678569 SGTC_2057 5236571 38.335 µM -1.80008885520999 0.0313136638370523 no 3228 0.0359233045410089 4561 54684039 YBR257W POP4 SGTC_2431 5490079 200 µM -1.80645966925323 0.0308523476774543 no 3229 0.0354232842017282 4642 5722345 SGTC_1868 st057644 42.7 µM -1.81147459527389 0.030493182156726 no 3230 0.0350337090643929 4648 688665 SGTC_1407 3909-7909 12.3 µM -1.81691159364426 0.030107708365319 no 3231 0.0346153255901693 4653 4411780 SGTC_609 0986-0026 86.3 µM -1.81927851911269 0.0299411641606903 no 3232 0.034434474441625 4634 2848610 SGTC_2997 9067075 71.4286 µM -1.8256095405356 0.0294994455382975 no 3233 0.0339545488439886 4596 27209819 SGTC_1071 trifluoperazine 6.31 µM -1.83248258444785 0.0290260477925417 no 3234 0.033439777044826 4669 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2782 7736369 71.43 µM -1.83727370138423 0.0286997958387379 no 3235 0.0330847501044722 4610 2950836 YOL077C BRX1 SGTC_2834 9001755 58.44 µM -1.84246040043626 0.0283500499689329 no 3236 0.0327039168942695 4501 2989575 SGTC_1965 Pectolinarigenin 58.4 µM -1.85001857966961 0.0278467481734804 no 3237 0.0321554358770691 4637 5320438 An anti-inflammatory. SGTC_1440 4100-1550 40 µM -1.86346579015458 0.0269696998968267 no 3238 0.0311983806473298 4666 742806 SGTC_740 k014-0057 261 µM -1.86537448569288 0.026847100701575 no 3239 0.0310644655575453 4626 4012779 SGTC_652 0437-0092 114 µM -1.87274375068828 0.0263781166570695 no 3240 0.0305518893662073 4628 3091274 SGTC_2987 9018338 71.43 µM -1.87437957435927 0.0262749459082265 no 3241 0.0304390633643043 4651 5055682 SGTC_3356 9151811 4.48 µM -1.87507190253335 0.0262313827562021 no 3242 0.0303914161911559 4674 1859254 YPR165W RHO1 SGTC_1629 st005085 44.9 µM -1.87738576920873 0.0260862259735629 no 3243 0.0302326202488405 4615 24207091 SGTC_2315 7733312 200 µM -1.88122492505886 0.0258468648194396 no 3244 0.0299706642572884 4569 726316 SGTC_2543 pimpinellin 60.67 µM -1.88142857227411 0.0258342194561656 no 3245 0.0299568215926498 4535 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2192 5915882 198.485 µM -1.90020576376004 0.024690303756759 no 3246 0.0287030610981724 4674 2876149 SGTC_820 1582-0060 59.9 µM -1.90702709418996 0.0242854071529356 no 3247 0.0282585395154533 4681 3848840 SGTC_1915 st067105 30.6 µM -1.90707540646923 0.0242825594664289 no 3248 0.0282554117307578 4597 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_157 1348-1695 65.819 µM -1.90748827574963 0.0242582350126915 no 3249 0.028228693917523 4578 5380510 SGTC_1062 mesoridazine 14.2 µM -1.90936276602765 0.024148055440926 no 3250 0.0281076552671758 4715 4078 A neuroleptic. SGTC_905 2-aminofluorene 215 µM -1.90955131905147 0.024136995898096 no 3251 0.0280955040707908 4671 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1862 st057513 3.81 µM -1.9153451123164 0.0237992303734556 no 3252 0.0277242529935931 4667 5393163 SGTC_1317 1273-0028 910 nM -1.91978152913702 0.0235432910193277 no 3253 0.0274427504664664 4667 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1505 k297-0037 20.6 µM -1.92689694133114 0.0231376351537834 no 3254 0.0269962373857544 4654 4089396 SGTC_2819 7996655 46.38 µM -1.92927259588227 0.0230035142286448 no 3255 0.0268485149694261 4643 6456960 SGTC_246 cycloheximide 667 µM -1.93212144517155 0.0228435424379689 no 3256 0.0266722589964726 4646 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_730 1436-0052 41.2 µM -1.94501690771031 0.0221310982345758 no 3257 0.0258864717020006 4683 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_3118 9124250 49.47 µM -1.94840138335634 0.0219472513221727 no 3258 0.0256834772156617 4654 1504786 SGTC_415 dibenzyl ketone 100 µM -1.9538170922067 0.0216557497628246 no 3259 0.0253614260849711 4658 7593 SGTC_3140 9094243 49.47 µM -1.97512801651933 0.0205402494016045 no 3260 0.0241268110853681 4651 19291112 SGTC_1074 carmofur 3.8 µM -1.98807638075696 0.0198865506812539 no 3261 0.0234016215702013 4720 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1637 st007924 17.4 µM -1.98936062210492 0.0198226887766566 no 3262 0.0233307063938756 4620 683336 SGTC_2662 daunorubicin 22.37 µM -2.01455673504291 0.018604522829956 no 3263 0.0219755572951871 4586 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1964 st076914 61 µM -2.01672171663999 0.0185028906336612 no 3264 0.0218622811658038 4712 24208661 SGTC_1993 st073995 70.8 µM -2.01704352113086 0.0184878243805648 no 3265 0.021845485885363 4673 3098394 SGTC_1664 st014217 9.02 µM -2.02514880983396 0.0181117815807799 no 3266 0.0214260431080342 4733 3982782 SGTC_1730 st033808 45.1 µM -2.02534871772734 0.0181025899011944 no 3267 0.0214157846563357 4629 1045166 SGTC_2451 5856223 45.7 µM -2.02657851711862 0.0180461316788262 no 3268 0.0213527677079999 4671 2179896 SGTC_2473 5854593 8.94 µM -2.02704136354181 0.0180249220174428 no 3269 0.0213290913374609 4677 2872951 SGTC_1446 4239-0190 62 µM -2.03700538725375 0.0175734537424434 no 3270 0.0208247510730374 4691 1340085 SGTC_3236 9132701 49.47 µM -2.04226341286525 0.0173391288055247 no 3271 0.020562704632933 4711 24282524 SGTC_1351 1496-0003 46.5 µM -2.04626018949219 0.017162801664059 no 3272 0.0203653891470813 4704 3891978 SGTC_2000 st075254 36.4 µM -2.04778238101089 0.0170960506962493 no 3273 0.020290663746586 4628 17234175 SGTC_2324 6149169 200 µM -2.05284202299225 0.0168757680341972 no 3274 0.0200439507197709 4683 2888231 SGTC_2434 5670830 169.91 µM -2.05797801633118 0.016654648229705 no 3275 0.0197961218702451 4695 1549830 SGTC_1215 3852-0577 11.2 µM -2.07148410811373 0.0160849681750778 no 3276 0.0191567890308449 4703 2884876 SGTC_1999 st074831 12.5 µM -2.09694701253231 0.0150562853780517 no 3277 0.0179991330992242 4690 17112523 SGTC_1233 0325-0408 14.2 µM -2.10164091933036 0.0148729591526646 no 3278 0.0177923712720379 4718 12874 SGTC_2556 citropten 84.59 µM -2.10324971092062 0.014810569060548 no 3279 0.0177219734521485 4680 2775 A potential DNA crosslinker. SGTC_1415 3966-0071 78.1 µM -2.12722361158711 0.0139071771835143 no 3280 0.0167007540937893 4655 2893185 SGTC_2325 6158266 200 µM -2.13165993968598 0.013745321626528 no 3281 0.0165174061763902 4689 3623240 SGTC_2293 7624732 200 µM -2.13544966232316 0.0136083464317562 no 3282 0.0163621488888248 4614 894453 SGTC_1960 st011366 51.8 µM -2.14763652701426 0.013175821355844 no 3283 0.0158713206576178 4737 3972846 SGTC_1293 1000-1278 195 µM -2.14977523819866 0.0131011542904971 no 3284 0.0157864988777847 4720 678847 SGTC_1098 clofazimine 15.1 µM -2.158338886611 0.0128058309968967 no 3285 0.0154507467173876 4738 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_527 4476-4215 268 µM -2.161242652506 0.012707008580575 no 3286 0.0153383001189725 4713 4418754 SGTC_2765 myclobutanil 7.74 µM -2.17172930088238 0.0123555965971822 no 3287 0.0149380435389773 4707 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1197 1601-0112 267 µM -2.18006114896028 0.0120824245797694 no 3288 0.0146264645686154 4702 7350313 SGTC_3187 9109394 49.47 µM -2.18477133090723 0.0119303231146723 no 3289 0.014452808549781 4709 17098090 SGTC_671 0560-0003 407 µM -2.19155542664665 0.0117141704997093 no 3290 0.0142058117118157 4719 3238678 SGTC_936 3005-4620 401 µM -2.19171087635223 0.011709257710895 no 3291 0.0142001949473641 4722 777207 SGTC_3284 9108171 64.8615 µM -2.20061968577733 0.0114306780680101 no 3292 0.0138814793923298 4703 8687505 SGTC_1355 1499-0035 1.68 µM -2.20371272463102 0.0113353140902418 no 3293 0.0137722768506991 4740 1548538 SGTC_1275 0867-0008 21.1 µM -2.20428934737522 0.0113176124355653 no 3294 0.013752000819351 4712 3422836 SGTC_3287 9117173 37.0625 µM -2.21575313360755 0.0109706406463858 no 3295 0.0133542068858251 4744 2789709 SGTC_517 1365-0151 113 µM -2.2204935595521 0.0108298905276234 no 3296 0.0131926411941959 4702 768657 SGTC_412 gemfibrozil 100 µM -2.22386708522576 0.0107306854081882 no 3297 0.0130786940934636 4706 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2513 baicalein 25.65 µM -2.2301464979947 0.0105481327535832 no 3298 0.0128688593900459 4701 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_3272 9137413 49.47 µM -2.23874576097551 0.0103025312229653 no 3299 0.0125862316021603 4706 17614870 SGTC_2142 5622915 118.518 µM -2.2458668138427 0.0101029377407162 no 3300 0.0123562700565027 4739 5322196 SGTC_2327 6189656 200 µM -2.24602399911671 0.0100985703766894 no 3301 0.0123512353698754 4742 5349088 SGTC_1850 st056238 17 µM -2.2910730955192 0.0089128279414875 no 3302 0.0109795932061133 4741 5393177 SGTC_1254 0550-0035 264 µM -2.30880646104896 0.00848064507741667 no 3303 0.0104771616701339 4720 15121435 SGTC_290 2043-6722 48.1 µM -2.31403703867979 0.00835673307425473 no 3304 0.0103328452629827 4755 773758 YLR208W SEC13 SGTC_2515 chrysin 20.77 µM -2.32563567351237 0.00808761852062908 no 3305 0.0100189974015072 4745 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1737 st035557 69.7 µM -2.3369628850304 0.00783218334821884 no 3306 0.00972055700978763 4655 5716916 SGTC_2019 4016004 108 µM -2.3450616153346 0.00765392998734656 no 3307 0.00951196773854135 4719 45595336 SGTC_199 4063-0024 41.6 µM -2.34511280426184 0.00765281477024256 no 3308 0.00951066187087222 4774 306215 SGTC_2352 9027995 87.8 µM -2.35553633336508 0.00742868378308383 no 3309 0.00924799407469834 4723 2997347 SGTC_3248 9135562 49.47 µM -2.37820799634518 0.00696106056643359 no 3310 0.00869850483120338 4741 17650701 SGTC_489 paxilline 115 µM -2.38108612277253 0.00690359562269014 no 3311 0.00863083788459225 4727 105008 A toxic potassium channel blocker. SGTC_3307 9126885 69.2785 µM -2.40137587809574 0.00651024003187296 no 3312 0.00816677460715148 4730 24824909 SGTC_1334 1486-0610 236 µM -2.4116522348147 0.00631868099646037 no 3313 0.00794021033464134 4770 3742339 SGTC_341 1486-1430 230 µM -2.42565779635861 0.00606564674398578 no 3314 0.00764033559719446 4733 2054753 YPL210C SRP72 SGTC_1457 k015-0032 57.3 µM -2.47931627319598 0.00517735105400923 no 3315 0.00658172633150069 4762 4302660 SGTC_2008 4012253 172 µM -2.48582648205992 0.00507786434728734 no 3316 0.00646254846181704 4743 603940 SGTC_2525 harmine 47.85 µM -2.4971171133105 0.00490935470763905 no 3317 0.00626037989575921 4779 5280953 A monoamine oxidase inhibitor SGTC_2859 9028643 45.46 µM -2.51755927989157 0.00461689802294945 no 3318 0.00590855410718448 4675 17151580 SGTC_2725 haloperidol 53.21 µM -2.53146802044318 0.00442690235280344 no 3319 0.005679308733698 4749 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_956 1185-0240 191 µM -2.53496835337211 0.00438020103436242 no 3320 0.00562287424876654 4741 1416193 SGTC_3154 9100113 49.47 µM -2.53707628271189 0.00435228996322327 no 3321 0.00558912968729883 4744 25237525 SGTC_3059 1327-0034 3 µM -2.54365497172624 0.00426620087946823 no 3322 0.00548496915305547 4684 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_900 1112-0045 141 µM -2.58852567991609 0.00371852932835045 no 3323 0.00481938798983196 4742 56211 YIL048W NEO1 SGTC_2775 cyproheptadine 69.59 µM -2.59617455035996 0.00363173438070275 no 3324 0.00471340812592431 4767 2913 A selective serotonin reuptake inhibitor. SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -2.60104544660834 0.00357741412694011 no 3325 0.00464700703901948 4749 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_803 4488-1585 147 µM -2.60324453795588 0.00355312969497863 no 3326 0.00461730300448668 4760 747204 SGTC_1340 1486-1359 257 µM -2.60436908166392 0.00354076870834533 no 3327 0.00460217890506996 4750 4309068 SGTC_2010 4012422 159 µM -2.60454169631392 0.00353887474976227 no 3328 0.0045998613119688 4738 952393 SGTC_3148 9097893 49.47 µM -2.64329343573223 0.00313601175962136 no 3329 0.0041051923079318 4752 17174100 SGTC_2785 7756463 72.73 µM -2.64860354638573 0.00308414977794745 no 3330 0.00404125425054403 4754 2201551 SGTC_2965 9082772 38.63 µM -2.72856055170256 0.0023912710719378 no 3331 0.00318057052402029 4764 16459634 SGTC_2773 thioridazine 9.09 µM -2.75220351370296 0.00221527813781582 no 3332 0.00295978605029434 4772 5452 An antipsychotic. SGTC_1337 1486-1011 40.3 µM -2.78241307757593 0.00200751048289081 no 3333 0.00269781582511281 4784 X1337 SGTC_38 0929-0051 58.268 µM -2.80508228201771 0.00186339844177141 no 3334 0.00251518682562673 4758 1379719 SGTC_935 2996-0153 430 µM -2.81717078988801 0.00179045543961067 no 3335 0.00242243774298348 4783 23738523 SGTC_750 4073-0104 132 µM -2.82361220304732 0.00175265726964444 no 3336 0.00237429007893243 4615 22330957 SGTC_1479 0549-0158 134 µM -2.86314172587351 0.00153617144066126 no 3337 0.00209731446560819 4804 5440202 SGTC_613 3914-0030 117 µM -2.87281960315094 0.00148702786539581 no 3338 0.00203413173686868 4687 1145395 SGTC_2600 tangeritin 87.95 µM -2.93937476605386 0.00118609119834847 no 3339 0.00164437573331885 4773 68077 A bioactive flavone. SGTC_3123 9126162 49.47 µM -3.04226623758415 0.000828970664236887 yes 3340 0.00117402057106064 4787 25239884 SGTC_3216 9129716 49.47 µM -3.04364484355564 0.000824942199657373 yes 3341 0.00116865447307698 4755 8056934 SGTC_3135 9127742 49.47 µM -3.06241552938653 0.000771854880778861 yes 3342 0.00109779216806479 4797 3643468 SGTC_3305 9127027 53.8275 µM -3.18088721504808 0.000503132266577134 yes 3343 0.000734123892740762 4788 41905295 SGTC_3153 9100258 49.47 µM -3.18481949264974 0.000495916795915768 yes 3344 0.000724221626018314 4770 25236848 SGTC_2331 7980721 200 µM -3.25327846031135 0.00038469305438642 yes 3345 0.000570408214487368 4787 2981221 SGTC_925 2064-1272 59.6 µM -3.73515537861844 5.63327163077335e-05 yes 3346 9.37996610848713e-05 4800 6815817 SGTC_3050 9093513 49.47 µM -3.73927099391528 5.5359889531368e-05 yes 3347 9.22773448013157e-05 4795 25236664 SGTC_1341 1486-1360 280 µM -3.74236648272542 5.46386611993345e-05 yes 3348 9.11476976300504e-05 4807 3976547 SGTC_1958 st076513 41.9 µM -3.91853654867817 2.54920724780614e-05 yes 3349 4.45441111626621e-05 4799 732122 YGL099W LSG1