SGTCid condition conc unit PPH22|YDL188C.score PPH22|YDL188C.strain.pval PPH22|YDL188C.strain.significant PPH22|YDL188C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_453 enantio-paf c16 10 µM 8.63551560553019 2.95289034667376e-18 yes 1 2.92313701956698e-18 9 13871343 A lipid and platelet activating factor
SGTC_3050 9093513 49.47 µM 6.92729222596354 2.14778910953614e-12 yes 2 2.14485946554946e-12 4 25236664
SGTC_1377 2944-0135 198 µM 4.04390301962827 2.61238570032147e-05 yes 3 2.62843354233112e-05 34 1894137
SGTC_1833 st055984 71 µM 3.96465257692462 3.65241816213095e-05 yes 4 3.67514604235249e-05 17 676288
SGTC_455 paf C-16 10 µM 3.85270966225958 5.80418804085582e-05 yes 5 5.84089378491713e-05 33 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_3046 9092212 49.47 µM 3.82302427727436 6.54965811678232e-05 yes 6 6.59123972956242e-05 8 25236637
SGTC_2713 st079149 53.4 µM 3.68373110571935 0.000114185618284634 yes 7 0.000114922351466165 32 3103253
SGTC_2799 7812892 81.82 µM 3.65438534834319 0.000128070635809286 yes 8 0.000128899415404894 38 20205235
SGTC_1133 3473-0247 50 µM 3.59445125265912 0.00016148708875909 yes 9 0.000162537999893231 67 711311
SGTC_3228 9131799 49.47 µM 3.53761931186241 0.000200564406081076 yes 10 0.000201875862038611 14 17015818
SGTC_2797 7859098 81.82 µM 3.46228814538963 0.000266052421112709 yes 11 0.00026780169843139 42 972681
SGTC_454 lyso-paf C-16 6.67 µM 3.40050549285704 0.000334101786217086 yes 12 0.000336306922671516 39 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3053 9095903 49.47 µM 3.32721264648151 0.000435710413933755 yes 13 0.000438597035203367 12 17174018
SGTC_1128 3448-9350 235 µM 3.28532733978617 0.000505961766600985 yes 14 0.000509319764307737 47 619386
SGTC_435 c-PAF 6.7 µM 3.26770713394783 0.000538535912043944 yes 15 0.000542112479197712 79 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2987 9018338 71.43 µM 3.25911598322016 0.000555112053906421 yes 16 0.0005587998402545 47 5055682
SGTC_3058 9093861 49.47 µM 3.18673912045899 0.000714674494996327 yes 17 0.00071943246820834 48 17217477
SGTC_2436 5633522 8.09 µM 3.18444501775257 0.000720363189791795 yes 18 0.000725159298076002 40 5724242
SGTC_2787 5284540 71.43 µM 3.16601076397715 0.000767612584683378 yes 19 0.000772725373601565 57 736958
SGTC_2923 7992654 58.14 µM 3.11651931650025 0.000908939205853696 yes 20 0.000914998455552366 61 2985126
SGTC_2697 mebhydrolin 72.4 µM 3.06627702305237 0.00107653206181775 no 21 0.00108371200436615 119 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_3057 9095946 49.47 µM 3.03971647110225 0.00117615958236517 no 22 0.00118400479808928 38 24540043
SGTC_251 melphalan 456.522 µM 3.03344293869395 0.00120089189874117 no 23 0.00120890215509044 72 460612 A DNA alkylator.
SGTC_1283 0922-0125 16.4 µM 2.99870173278488 0.00134668077925314 no 24 0.00135566297287151 58 3360884
SGTC_3002 9075603 71.4286 µM 2.95604257707489 0.00154775030940558 no 25 0.00155807035499022 73 20105405
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 2.91165995553008 0.00178566978134236 no 26 0.0017975689023904 23 1241132 A phosphatase inhibitor.
SGTC_656 4090-1979 187 µM 2.90546570772443 0.00182139926043392 no 27 0.00183353514836969 74 22330961
SGTC_2972 9093619 59.92 µM 2.89065467548506 0.0019094823084389 no 28 0.00192220148149027 63 25236256
SGTC_1230 0170-0365 3.77 µM 2.87640131206555 0.00199788577107807 no 29 0.00201118976596242 163 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1261 0712-0010 12.7 µM 2.87060713082811 0.00203487322908897 no 30 0.00204842173671396 81 2840123
SGTC_3346 9158254 43.5805 µM 2.85411003833768 0.00214361223420172 no 31 0.00215787899420504 75 17639500
SGTC_619 1652-1634 108 µM 2.83238226897155 0.00229486446007468 no 32 0.00231012883758916 77 5400454
SGTC_1701 st028638 40.4 µM 2.82260476192322 0.0023660296186986 no 33 0.002381762804971 60 3490878
SGTC_1173 0443-0020 122 µM 2.76031506424836 0.00286825071738656 no 34 0.00288728208625905 120 5331295
SGTC_705 1124-0212 310 µM 2.75213187222731 0.00294092646560751 no 35 0.00296043365301128 70 9554485
SGTC_2515 chrysin 20.77 µM 2.74883859231981 0.00297063982867698 no 36 0.00299034144974299 56 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1369 1866-0067 208 µM 2.74258405960783 0.0030278166791083 no 37 0.00304789227621552 119 3531355
SGTC_462 ag-879 158 µM 2.72713815049411 0.00317328816700165 no 38 0.00319431425351007 108 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1167 k781-0610 148 µM 2.72330792567181 0.00321032146079002 no 39 0.00323158929122699 93 4525169
SGTC_1322 1348-1070 12 µM 2.70741863361897 0.00336813752704058 no 40 0.00339043452307629 47 6758089
SGTC_424 splitomicin 100 mM 2.70253849467175 0.00341798903951886 no 41 0.00344061079229415 94 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3097 9117246 49.47 µM 2.67754296863794 0.00368386586726314 no 42 0.00370821695626933 87 16423892
SGTC_2292 7671323 168.05 µM 2.67475317034778 0.00371466325898649 no 43 0.0037392143706782 123 937504
SGTC_1293 1000-1278 195 µM 2.65475116853165 0.00394231864482715 no 44 0.00396834648157382 89 678847
SGTC_3281 9140613 49.47 µM 2.65171869079698 0.00397790327147627 no 45 0.0040041616421494 86 16013766
SGTC_2389 9091542 195.52 µM 2.63742102614189 0.00414958423577857 no 46 0.00417695374291977 121 3626624 YOL127W RPL25
SGTC_2768 sulfasalazine 50.2 µM 2.62730975255184 0.0042749677260439 no 47 0.00430314759470327 93 5384001 An antioxidant and salicylic acid derivative.
SGTC_2586 curcumin 80 µM 2.61129925349665 0.00448044050888882 no 48 0.00450994632423125 163 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_410 α-linolenic acid 100 µM 2.57412919337971 0.00499184180562448 no 49 0.00502463705014188 106 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1692 fluoroquinolonic acid 71 µM 2.57019930990883 0.00504884003660473 no 50 0.00508200097765466 65 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_817 1391-0715 46 µM 2.56310516416844 0.00515320098823843 no 51 0.00518703102876358 95 1353946
SGTC_329 k048-0121 21.3 µM 2.55136475364512 0.00533013500387194 no 52 0.00536509805366135 95 6832902
SGTC_1747 st037496 66.6 µM 2.54760038496458 0.00538799884903241 no 53 0.00542333205930722 112 723305
SGTC_1710 st031758 61.5 µM 2.54681319487366 0.0054001694749615 no 54 0.00543558051852691 84 5394341
SGTC_3248 9135562 49.47 µM 2.5053703069446 0.00607643911056389 no 55 0.00611616250093717 92 17650701
SGTC_2951 9072950 58.06 µM 2.48912148829332 0.00636142642398451 no 56 0.00640295989410509 122 16488155
SGTC_1647 st011722 22.4 µM 2.47732024567667 0.00657576136288344 no 57 0.00661865343770613 89 2854783
SGTC_984 1492-0255 2.91 µM 2.46503045421535 0.00680573309966137 no 58 0.00685008033228166 118 1585198
SGTC_2784 7567673 72.73 µM 2.44018043986491 0.00729254473598551 no 59 0.00733996371695786 162 3471247
SGTC_621 3584-0052 32.1 µM 2.43842591715476 0.00732804842783072 no 60 0.00737569098622656 129 2273927
SGTC_483 fpl-64176 144 µM 2.42829007392414 0.00753615044570944 no 61 0.00758510227784432 69 3423
SGTC_1653 st012112 65 µM 2.4108331681551 0.00790678487610338 no 62 0.00795806351012451 92 720429
SGTC_2771 fluoxetine 41.05 µM 2.39806061969887 0.00818802862845651 no 63 0.00824106864144494 115 3386 A selective serotonin reuptake inhibitor.
SGTC_2947 9072639 7.68 µM 2.39620856211317 0.00822953104082076 no 64 0.00828283067047134 193 16488146
SGTC_2913 7966556 36.57 µM 2.38822029442924 0.00841066327043886 no 65 0.00846509505458742 103 2976516
SGTC_234 nsc-17383 10.7 µM 2.38240548578314 0.00854470464110654 no 66 0.00859997329376211 149 408974
SGTC_343 4130-2827 29.8 µM 2.37917593761935 0.00861995792105695 no 67 0.008675696056211 141 1118244
SGTC_1740 st038286 13.222 µM 2.37731499264647 0.00866358418623001 no 68 0.00871959437750626 151 716786
SGTC_1393 3470-5649 58.2 µM 2.37655250152619 0.00868151516863575 no 69 0.00873763715423217 92 4108395
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 2.37269873119582 0.00877264044537028 no 70 0.00882933035069658 127 688669
SGTC_3206 9114350 49.47 µM 2.36917393304343 0.00885672001736167 no 71 0.00891393360776838 125 17087243
SGTC_2002 4023503 131 µM 2.36878139556158 0.0088661270620425 no 72 0.00892339922445769 176 4736863 YCR052W RSC6
SGTC_909 3448-9333 149 µM 2.36625572659282 0.00892686365070712 no 73 0.00898451389026928 112 3344074
SGTC_1009 4106-0057 9.87 µM 2.36398779706429 0.00898171251610808 no 74 0.00903970404435997 114 2928005
SGTC_1897 st060201 15 µM 2.36380488272318 0.00898614905567214 no 75 0.00904416818389399 126 611878
SGTC_703 3875-0075 71.8 µM 2.36377133919626 0.00898696285341507 no 76 0.00904498704422707 87 2850814
SGTC_1843 st055809 45.5 µM 2.3552206733961 0.00919652743556993 no 77 0.0092558543617417 128 16413835
SGTC_491 tetrandrine 80.3 µM 2.32768200139846 0.00990080649152216 no 78 0.00996449778011736 92 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_692 k241-0027 77.8 µM 2.32138432466887 0.0100683290345455 no 79 0.0101330553920401 119 3600480
SGTC_1889 st059080 5.18 µM 2.30638430890417 0.0104773353368414 no 80 0.010544583984286 151 176925 Isolated from Daphnopsis sellowiana.
SGTC_1983 st071813 46.9 µM 2.3049782527546 0.0105164064673556 no 81 0.0105838957063289 132 11838595
SGTC_2 0422-0095 29 µM 2.29044727505739 0.0109276827649745 no 82 0.0109977008461483 70 6790840
SGTC_1119 parthenolide 318.541 nM 2.28680087077895 0.0110330593887077 no 83 0.0111037243254928 217 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_958 1222-0007 33 µM 2.27203477297121 0.0114688695345276 no 84 0.0115422050811449 178 7312461
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 2.27075309804621 0.0115073930755858 no 85 0.0115809643368052 247 6708739 YPR165W RHO1
SGTC_1411 3909-8223 150 µM 2.26622889615897 0.0116442777862658 no 86 0.0117186861443064 119 X1411
SGTC_2290 7904846 200 µM 2.24977323107089 0.0121541519273996 no 87 0.0122316720583599 192 2962154
SGTC_733 4069-0007 56.1 µM 2.24842377010504 0.0121968104097588 no 88 0.0122745904416561 262 5717425 YNL287W SEC21
SGTC_2924 9010168 62.78 µM 2.21651406000518 0.0132440188458755 no 89 0.0133281580223949 175 2993929
SGTC_3184 9108758 49.47 µM 2.21173382197372 0.0134074033164996 no 90 0.0134925310479203 104 902885
SGTC_549 1661-1316 519 µM 2.20662965695504 0.0135837778262439 no 91 0.0136699716392021 159 2857282
SGTC_995 3931-2021 34.6 µM 2.19830649316742 0.013875680229785 no 92 0.013963636003081 162 730143
SGTC_2655 perillic acid 100 µM 2.196332712118 0.0139456910644304 no 93 0.0140340689864185 92 5702197 An apoptosis inducer.
SGTC_3311 9131146 2.8755 µM 2.19345405366196 0.0140483441600871 no 94 0.0141373407458272 264 4900406 YPR165W RHO1
SGTC_387 norethindrone acetate 66.7 µM 2.19345070788884 0.0140484638484028 no 95 0.0141374611552588 146 541197
SGTC_381 3461-2219 42.7 µM 2.19260197145162 0.0140788540935748 no 96 0.0141680344839331 173 2883159
SGTC_2824 7998404 51.95 µM 2.18768836915959 0.014255908525604 no 97 0.01434615492717 163 837851
SGTC_2961 9083290 32.55 µM 2.1706862157494 0.0148834340126969 no 98 0.0149774499352527 149 17741490
SGTC_1888 azatryptophan 97.5 µM 2.16498729274278 0.0150990213559672 no 99 0.0151943292111243 142 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_624 k048-0052 28 µM 2.16192870841755 0.0152158286966179 no 100 0.015311835880237 172 6835531
SGTC_1835 st008666 49.2 µM 2.15176241981259 0.0156096737574766 no 101 0.0157080355444094 147 690455
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 2.14546059884736 0.0158581744228151 no 102 0.0159580192291696 195 1377
SGTC_1928 4'-methoxychalcone 40.3 µM 2.13738968643293 0.0161813841340378 no 103 0.0162831547867094 151 641818
SGTC_1088 bifonazole 369 nM 2.13393397301143 0.0163214886074862 no 104 0.0164240930178965 158 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2979 9012552 45.46 µM 2.13373501920048 0.0163295862938361 no 105 0.0164322388739337 127 17100905
SGTC_2584 androsterone 48.74 µM 2.12888881779396 0.0165278984835092 no 106 0.0166317300785669 351 2754130 A steroid.
SGTC_2112 5488546 200 µM 2.12242846503052 0.0167954666181601 no 107 0.0169008869724084 191 600757
SGTC_3078 9116413 49.47 µM 2.12175940510398 0.0168233875960684 no 108 0.0169289736071137 195 17177322
SGTC_517 1365-0151 113 µM 2.11772757046047 0.0169924845069005 no 109 0.017099073250646 200 768657
SGTC_1271 0832-2808 169 µM 2.10227907504677 0.0176539158989039 no 110 0.0177644182327718 179 3663794
SGTC_1527 coumarin 137 µM 2.09891339362814 0.017800897828615 no 111 0.017912267979167 198 323 A hepatotoxic, DNA x-linker.
SGTC_416 estradiol valerate 100 µM 2.09807644851677 0.0178376095297335 no 112 0.0179491963306827 183 13791 A steroid.
SGTC_809 3998-0021 90 µM 2.09005720799051 0.0181926506218378 no 113 0.0183063305213947 149 715485
SGTC_1469 k284-2957 126 µM 2.08199084100764 0.0185558361351578 no 114 0.018671653161811 158 23884841
SGTC_625 k213-0058 121 µM 2.06721205041543 0.0192372724737704 no 115 0.0193570886042372 373 3655420
SGTC_3338 9144300 39.5675 µM 2.05997823529236 0.0195784973181911 no 116 0.0197003107764716 204 4901274
SGTC_1211 1056-0033 32.3 µM 2.05274740617086 0.0199247044268514 no 117 0.0200485408742268 171 6741922
SGTC_896 0964-0007 44.5 µM 2.05225895221245 0.0199482774071782 no 118 0.0200722514708836 152 6756758
SGTC_842 0271-0008 11.1 µM 2.04301289199423 0.020398978862747 no 119 0.0205255809655628 201 1221709
SGTC_3161 9100388 49.47 µM 2.03531108008749 0.0207809661135818 no 120 0.0209097909979951 152 25236368
SGTC_514 4466-0038 2.65 nM 2.02694186915544 0.0212029036851556 no 121 0.0213341789831443 386 5722064
SGTC_2035 5154463 94.595 µM 2.0227957535719 0.0214146019942191 no 122 0.0215471048381586 239 2769623
SGTC_1227 3909-8010 46.6 µM 2.0182984219543 0.0216462508563413 no 123 0.021780095488097 214 15982272
SGTC_1414 3917-0015 5.4 µM 2.0098261867776 0.0220883925883966 no 124 0.0222247940978076 171 6618702
SGTC_452 diindolylmethane 8 µM 1.98127560191811 0.0236348848546525 no 125 0.0237801874659677 178 3071 Inhibits expression of several cancer promoting factors.
SGTC_2888 9058547 12.99 µM 1.97930925932362 0.0237446668433349 no 126 0.0238905988701504 164 16476514
SGTC_1637 st007924 17.4 µM 1.97706937714551 0.0238702427359719 no 127 0.0240168943362456 224 683336
SGTC_400 oxethazaine 37.5 µM 1.97016732872195 0.0242607118999751 no 128 0.0244095982907076 223 4621 A local anesthetic.
SGTC_1141 3253-0389 52.6 µM 1.96764502262516 0.0244047381141893 no 129 0.0245544478012068 187 5402031
SGTC_1004 4084-0029 199 µM 1.96647926475148 0.0244715462132077 no 130 0.0246216376099584 226 716894 YLR208W SEC13
SGTC_69 0096-0274 206.684 µM 1.964520703602 0.0245841344542813 no 131 0.0247348688619974 311 6741392
SGTC_907 3448-6986 75.5 µM 1.96374554382236 0.0246288145613218 no 132 0.0247798040529171 260 590582
SGTC_3223 9129970 49.47 µM 1.96045996866564 0.0248189518351526 no 133 0.0249710262594741 239 17248386
SGTC_2119 5528445 120.635 µM 1.95986068765212 0.0248537648379961 no 134 0.0250060378049961 218 791935
SGTC_3070 9117005 49.47 µM 1.95817299879954 0.0249520249768392 no 135 0.0251048581630475 148 8779016
SGTC_699 0375-0592 111 µM 1.95630765549271 0.0250610072131892 no 136 0.0252144614562974 210 762578
SGTC_289 k017-0060 526 µM 1.95277968498549 0.0252682191366228 no 137 0.0254228533700211 187 5512909
SGTC_315 k915-0449 187 µM 1.94670960549022 0.0256280987140945 no 138 0.0257847796907991 311 20970215 YNL149C PGA2
SGTC_2757 clomiphene 4.22 µM 1.94438230476325 0.0257672117937116 no 139 0.0259246830583219 279 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_3315 9136395 68.55 µM 1.93868217735891 0.0261106051457115 no 140 0.0262700250823363 226 16876844
SGTC_391 gliotoxin 8.33 µM 1.93562404496763 0.0262964085406086 no 141 0.0264568816174157 278 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_611 3453-1652 23.7 µM 1.9315630235471 0.0265448518263934 no 142 0.0267067317262246 282 1560575
SGTC_1320 1313-0481 95.3 µM 1.92328771134194 0.0270571873765453 no 143 0.0272219635116865 224 6813365 YLR208W SEC13
SGTC_658 3253-0951 102 µM 1.90381811706329 0.0282951903639105 no 144 0.0284669380870483 339 1184878
SGTC_812 4251-0442 148 µM 1.90343136360882 0.028320252425128 no 145 0.0284921408928237 210 5723007
SGTC_1581 himbacine 57.9 µM 1.90012700602957 0.028535132642455 no 146 0.0287082272173286 298 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1321 1326-2144 215 µM 1.89333798957957 0.0289808751454499 no 147 0.0291564680803193 223 3513030
SGTC_2326 6164455 177.58 µM 1.89154683297223 0.0290994360717163 no 148 0.0292756927282728 242 2888790
SGTC_2484 5809818 12.04 µM 1.88602047618817 0.0294677811505192 no 149 0.0296460977110524 241 2870548
SGTC_2663 amphotericin b 100 µM 1.88347655921335 0.0296386358707716 no 150 0.0298179068074525 240 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3259 9138485 49.47 µM 1.86875472411503 0.0306436026748305 no 151 0.0308284732862009 279 17646153
SGTC_2030 5175110 200 µM 1.86776488571932 0.0307121731398853 no 152 0.0308974249622604 236 2831986
SGTC_979 1426-2828 121 µM 1.86416087358992 0.0309629131908089 no 153 0.0311495580464819 301 747872
SGTC_2986 9022445 71.43 µM 1.8623302473405 0.0310909217673917 no 154 0.0312782772355532 269 6459286
SGTC_2678 equilin 100 µM 1.85787110862961 0.0314045650496355 no 155 0.0315936600392908 273 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2123 5259487 200 µM 1.85461559493626 0.0316351971034621 no 156 0.0318255697725449 267 2173474
SGTC_1413 3910-0535 34.4 µM 1.85434882824636 0.0316541576823917 no 157 0.0318446353368763 252 2876951
SGTC_1970 st070122 35.8 µM 1.85213622502739 0.0318117818181818 no 158 0.0320031319239718 285 102928
SGTC_2822 7994718 71.43 µM 1.84828108930286 0.0320879675576384 no 159 0.0322808449840529 219 1018011
SGTC_489 paxilline 115 µM 1.83496683015999 0.0330570792087067 no 160 0.0332553021690936 239 105008 A toxic potassium channel blocker.
SGTC_1571 st070080 73.4 µM 1.826092813177 0.0337162942253838 no 161 0.033918141292965 279 4315245
SGTC_2373 9071805 200 µM 1.82583964106721 0.0337352589307131 no 162 0.0339372101155316 246 10149009
SGTC_2011 4012611 177 µM 1.82523314732017 0.0337807260781828 no 163 0.033982926847527 293 2049887
SGTC_788 1182-0090 188 µM 1.8240364640269 0.0338705859765312 no 164 0.0340732798823012 391 5715185
SGTC_874 0599-0792 117 µM 1.82137440271216 0.0340711876067268 no 165 0.0342749817361634 325 765305
SGTC_2943 9068529 45.32 µM 1.81753151020771 0.0343624937475241 no 166 0.0345678839981283 295 3270634
SGTC_2945 9067681 61.76 µM 1.80902285855443 0.0350147686692437 no 167 0.0352237260997554 236 16456930
SGTC_819 1013-0258 27.7 µM 1.80857644267395 0.0350492696556844 no 168 0.0352584155073116 314 5753198
SGTC_2806 7952793 58.44 µM 1.80768191571719 0.0351184865986414 no 169 0.0353280103883782 284 2972490
SGTC_275 trichlorophene 5.69 µM 1.80408397473937 0.0353980227187822 no 170 0.0356090717714946 511 62616
SGTC_3072 9116419 49.47 µM 1.80347396111659 0.035445597150165 no 171 0.0356569056196126 253 17170162
SGTC_2096 5468907 200 µM 1.79599945893744 0.0360327951860224 no 172 0.0362473015404744 259 759785
SGTC_3035 9091303 49.47 µM 1.79280911955861 0.036285843228481 no 173 0.0365017253988701 217 25237002
SGTC_723 4182-0001 115 µM 1.79204206583148 0.0363469000365947 no 174 0.0365631139660597 279 744821 YLR208W SEC13
SGTC_2767 sibutramine 71.45 µM 1.7846934951566 0.0369361119181952 no 175 0.0371555233134581 285 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2520 obtusaquinone 4.71 µM 1.78267510228554 0.037099307569919 no 176 0.0373196032724268 258 5967872
SGTC_3247 9135149 49.47 µM 1.77141146997728 0.0380208724577684 no 177 0.0382461513056505 243 8934436 YOR116C RPO31
SGTC_2658 polymyxin b sulfate 77.05 µM 1.76746990546476 0.0383477403144141 no 178 0.0385747823515329 306 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2315 7733312 200 µM 1.76642921968728 0.0384344240213276 no 179 0.0386619332743258 272 726316
SGTC_1621 st003705 32.4 µM 1.76366686199403 0.0386652888852593 no 180 0.0388940417144691 340 24207032
SGTC_1650 st011916 45.8 µM 1.76175308966068 0.0388258945486715 no 181 0.0390555118450774 250 242528
SGTC_2687 chenodiol 100 µM 1.76084795716934 0.0389020432043972 no 182 0.0391320701880902 271 5702181 A cholesterol synthesis inhibitor.
SGTC_1498 4478-3555 97.6 µM 1.75812805327519 0.0391316004364868 no 183 0.0393628617371682 218 3437919
SGTC_371 0195-0006 7.36 µM 1.75419432360816 0.0394655527639886 no 184 0.0396986077735803 253 3928593
SGTC_349 k015-0014 24 µM 1.74905363877663 0.0399054596774438 no 185 0.0401408740091359 288 2196908
SGTC_1430 4049-0248 69.1 µM 1.74416865869041 0.0403271699711377 no 186 0.0405648423315921 349 22774488
SGTC_222 nsc-310342 10.666 µM 1.72985357611813 0.0415838398469875 no 187 0.04182821969992 165 432556
SGTC_480 am 92016 50 µM 1.72791654373948 0.0417562960486295 no 188 0.0420015939202622 264 2129 K+ channel blocker.
SGTC_2558 carylophyllene oxide 100 µM 1.72667639535391 0.041867011685778 no 189 0.0421128986067574 322 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_863 0466-0191 129 µM 1.72316930077 0.0421813985263111 no 190 0.0424289567780679 368 765160 YPR165W RHO1
SGTC_2607 solasodine 47.35 µM 1.72280942542841 0.0422137666577734 no 191 0.042461496872469 367 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2282 7944268 200 µM 1.71717291509748 0.0427233565792925 no 192 0.0429737913769078 366 2970414
SGTC_1084 voriconazole 435 nM 1.71612894319764 0.0428182843968796 no 193 0.043069222446371 301 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3202 9113761 49.47 µM 1.71041289575503 0.043341067641174 no 194 0.0435947740153614 404 4798415
SGTC_155 k072-0202 43.6 µM 1.70876495357245 0.0434927399510028 no 195 0.0437472484842886 275 5857737
SGTC_2673 kobusone 100 µM 1.70740487789141 0.0436182402397369 no 196 0.0438734121754393 242 6710676 An epoxy ketone and protein crosslinker.
SGTC_246 cycloheximide 667 µM 1.70408723877832 0.0439255998034769 no 197 0.044182395167412 257 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2949 9072542 2.23 µM 1.70152655643567 0.0441640242978352 no 198 0.0444220777229497 379 16457352
SGTC_2111 5486399 200 µM 1.7002333561133 0.0442848297417618 no 199 0.0445435201842423 379 689674
SGTC_2872 9044037 25.97 µM 1.69815018595866 0.0444799908471918 no 200 0.0447397097954833 235 6465195
SGTC_3273 9137859 49.47 µM 1.6965899862349 0.0446266110006798 no 201 0.0448871021593799 253 2377234
SGTC_3137 9097352 49.47 µM 1.69303029009933 0.0449625917659038 no 202 0.0452248508898929 375 44120435
SGTC_1884 5633444 25 µM 1.69088058999996 0.0451664746404978 no 203 0.0454298055619215 387 5724239
SGTC_2117 5521686 200 µM 1.69073274698543 0.0451805237327836 no 204 0.0454439284799726 323 803312
SGTC_620 0109-0052 432 µM 1.68433568131866 0.045791793438549 no 205 0.0460584066662813 311 493037
SGTC_787 4152-0075 138 µM 1.68416012260466 0.0458086621464968 no 206 0.0460753638152198 336 9566539
SGTC_604 1000-0114 314 µM 1.67749739993492 0.0464525552267419 no 207 0.046722628735175 352 1572745
SGTC_2075 5212009 200 µM 1.67467541872099 0.0467274557670434 no 208 0.0469989664485058 276 780898
SGTC_2877 9040724 71.43 µM 1.65884347160189 0.0482939954413344 no 209 0.0485736689720765 302 6463895
SGTC_2864 9034755 47.6 µM 1.65712328433802 0.0484667055513731 no 210 0.0487472762421816 329 4930451
SGTC_212 3807-4682 38.772 µM 1.65454956513428 0.0487260338744352 no 211 0.0490079506392064 484 3125501 YBL034C STU1
SGTC_1817 st052116 64.4 µM 1.65072901955867 0.0491130364843546 no 212 0.0493969597314189 328 4361398
SGTC_1718 roemerine 11.9335 µM 1.64931619691782 0.0492567688105004 no 213 0.0495414365632642 406 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3198 9112019 49.47 µM 1.64463173313017 0.0497357433154319 no 214 0.050022889338021 325 45595555
SGTC_473 2-arachidonoylglycerol 10 µM 1.64031561555933 0.0501803375596241 no 215 0.0504697802257673 343 5282280 An endocannabinoid.
SGTC_1789 tunicamycin 25 nM 1.63647932989247 0.0505781594726446 no 216 0.0508696541322237 352 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1112 tnp00069 1.16933 µM 1.63502235397115 0.0507299041892843 no 217 0.0510221808053376 394 145826
SGTC_3163 9099914 49.47 µM 1.63356436072119 0.0508821175706643 no 218 0.0511751781412283 241 16268368
SGTC_1345 1488-0192 31.4 µM 1.63289817677551 0.0509517875822953 no 219 0.0512452068396957 358 658348
SGTC_33 0986-0033 35.816 µM 1.63251705358187 0.0509916798648148 no 220 0.051285304463039 302 2848082
SGTC_738 1315-0003 72.4 µM 1.63248892780898 0.0509946247829055 no 221 0.0512882645386143 364 6251474
SGTC_2525 harmine 47.85 µM 1.6282307360208 0.0514420441073341 no 222 0.0517379849200328 267 5280953 A monoamine oxidase inhibitor
SGTC_2079 5212404 121 µM 1.62041530430955 0.0522713508182592 no 223 0.0525715472516734 334 758462
SGTC_1208 2323-2347 50.3 µM 1.62032203120539 0.0522813118929479 no 224 0.0525815593675906 330 5412760
SGTC_370 0180-0345 38.7 µM 1.60931283418237 0.0534676632068692 no 225 0.0537739770732153 318 3989527
SGTC_1821 st053465 65.6 µM 1.59568379559533 0.0549657650257586 no 226 0.0552797041430306 337 675086
SGTC_1142 3253-1408 9.78 µM 1.59541613634192 0.0549955148297369 no 227 0.0553096049764485 351 256655
SGTC_2896 9052656 71.43 µM 1.59354892421179 0.0552034059358218 no 228 0.0555185510461819 532 6469436
SGTC_1385 3091-4834 14.1 µM 1.59058681978659 0.0555344727097258 no 229 0.0558512963095926 345 4072814
SGTC_602 3130-1533 38.1 µM 1.58928754949053 0.0556801824378022 no 230 0.0559977441788456 414 720941
SGTC_713 1488-1073 324 µM 1.5843137395719 0.0562407721518656 no 231 0.0565611703448262 335 3312542
SGTC_2435 5706476 10.6 µM 1.58365586830985 0.0563152517499029 no 232 0.0566360263866167 408 5725375
SGTC_1861 st057647 17.4 µM 1.58346329998588 0.0563370676974409 no 233 0.0566579525809702 367 688668
SGTC_2984 9022109 38.96 µM 1.58194921853651 0.0565088292452678 no 234 0.0568305818409392 284 6459207
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.57867530039998 0.0568816422517631 no 235 0.057205276506946 329 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1053 3366-3204 134 µM 1.57681858565185 0.0570939322744648 no 236 0.0574186369407736 414 3632071 YPR165W RHO1
SGTC_1280 0880-0253 10.1 µM 1.5765204992566 0.0571280724190745 no 237 0.0574529491556859 401 6836607
SGTC_41 0478-0632 82.643 µM 1.57309819390345 0.0575211849001445 no 238 0.0578480415443306 449 3750424
SGTC_511 blebbistatin 171 µM 1.56701975663706 0.0582246437768857 no 239 0.0585550368617503 379 3476986 A myosin inhibitor.
SGTC_2473 5854593 8.94 µM 1.56633980375598 0.0583037533720149 no 240 0.0586345436361979 342 2872951
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.56563233994858 0.0583861533419662 no 241 0.0587173571932967 397 4330530
SGTC_811 0416-0114 265 µM 1.56388088124468 0.058590543351379 no 242 0.0589227725976479 378 6612453
SGTC_2058 5236698 133 µM 1.55746718560853 0.0593438006009329 no 243 0.0596798027880824 395 766665
SGTC_2725 haloperidol 53.21 µM 1.55610483618677 0.0595047753479392 no 244 0.0598415826023153 388 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1139 k015-0024 46.9 µM 1.54515189818116 0.0608114368742432 no 245 0.0611547630950244 362 2766652
SGTC_948 3448-0295 75.3 µM 1.5445363020479 0.0608855368862062 no 246 0.061229231948406 451 678569
SGTC_392 N-ethylmaleimide 8.33 µM 1.54093815901282 0.0613200626290729 no 247 0.0616659187765514 367 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_291 SEC14.278 35.5 µM 1.5395903327875 0.0614834537337982 no 248 0.0618301216944537 408 1068044
SGTC_310 1273-0058 1.06 µM 1.53881126478429 0.0615780517180251 no 249 0.0619251894914358 662 2734232
SGTC_898 1000-0849 28.3 µM 1.53723912356596 0.0617692943346413 no 250 0.0621173814508056 384 6751807
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.53359044211486 0.062214923642096 no 251 0.0625652205781425 368 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1124 fisetin 1.16336 µM 1.53079254069755 0.0625583391885199 no 252 0.0629103368722222 378 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1043 0916-0009 19.3 µM 1.5272015842772 0.0630012578579605 no 253 0.0633554462458522 494 3101130
SGTC_2472 5377652 49.4 µM 1.52659876976807 0.0630758495583633 no 254 0.0634304065689122 462 1610903
SGTC_816 0325-0417 81.3 µM 1.52390794207788 0.0634096491096831 no 255 0.0637658546131967 369 68101
SGTC_1815 st051655 58.2 µM 1.52384142248822 0.0634179183054754 no 256 0.0637741646241667 352 5984156
SGTC_592 k241-0073 46.5 µM 1.52245640457009 0.0635902836641655 no 257 0.063947380494447 424 4230158
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.51818639322637 0.064123981102302 no 258 0.0644837083516245 455 5379071
SGTC_2044 5102272 200 µM 1.51508067837247 0.0645143387475065 no 259 0.0648759870462821 359 592666
SGTC_305 1682-2595 20.8 µM 1.51250443931734 0.0648395452145127 no 260 0.065202792075511 406 226033
SGTC_3089 9117425 49.47 µM 1.50887313211515 0.0653000957496061 no 261 0.0656656035741669 403 9401657
SGTC_3016 9080866 49.47 µM 1.50360914710662 0.0659722158717281 no 262 0.0663410172602447 436 17066299
SGTC_1307 1187-1599 12.2 µM 1.49856531435298 0.0666212433180606 no 263 0.0669932183258281 409 1538471
SGTC_524 r073-0010 27.8 µM 1.49267141786248 0.0673859037788394 no 264 0.0677616093194261 413 2772106
SGTC_2043 5101342 149 µM 1.49006048175827 0.0677268011679634 no 265 0.0681041668832071 434 678451
SGTC_263 alizarin 107.927 µM 1.48385142875442 0.0685428374883835 no 266 0.06892416994459 516 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2397 5161689 200 µM 1.47889501097302 0.0691996706828897 no 267 0.0695841884799259 459 2259942
SGTC_1228 0124-0032 52.5 µM 1.47607103009088 0.0695760723296421 no 268 0.0699624124943002 459 X1228
SGTC_649 1123-0311 367 µM 1.47432736416702 0.0698092673544457 no 269 0.0701967354482459 499 693629 YIL048W NEO1
SGTC_536 3852-0578 10.6 µM 1.47332893610531 0.0699430660681629 no 270 0.0703311809480908 419 2869208
SGTC_2080 5212524 12.4 µM 1.47202010197533 0.0701187608797534 no 271 0.0705077246543982 394 260183
SGTC_385 1494-0393 12.4 µM 1.4678280507418 0.0706837774268006 no 272 0.0710754679482966 442 3090647
SGTC_546 peri-Naphthalide 147 µM 1.46367659577114 0.0712467639777739 no 273 0.0716411665904459 443 223824 A penicillin ester.
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.46291429099168 0.0713505146321537 no 274 0.0717454165180143 418 689007
SGTC_1579 chlormadinone acetate 49.4 µM 1.46217973072178 0.0714505988996856 no 275 0.0718459822598093 448 45114258 A steroidal progestin.
SGTC_2356 9061756 188.97 µM 1.45707234461917 0.0721494645539182 no 276 0.0725482056949251 403 20104043
SGTC_634 1611-4317 11.2 µM 1.45004037771985 0.0731202368294916 no 277 0.0735236298861051 481 2843522
SGTC_2786 7743617 45.45 µM 1.44237163852126 0.0741902759511513 no 278 0.0745987801728567 388 583674
SGTC_912 3474-0017 2.18 µM 1.44122782620319 0.0743508948261672 no 279 0.0747601647819217 464 3360550
SGTC_1509 1326-1131 80 µM 1.44038241033093 0.0744697821843701 no 280 0.0748796186752745 398 768313
SGTC_3293 9120939 62.045 µM 1.43839254170335 0.0747501819619433 no 281 0.0751613538096625 443 934087
SGTC_1794 st048918 76.9 µM 1.43777381146662 0.0748375335262185 no 282 0.0752491211317155 356 672303
SGTC_1472 k841-0093 193 µM 1.43768687738951 0.0748498130081061 no 283 0.0752614590498141 495 X1472
SGTC_2990 9074105 71.4286 µM 1.4373741872586 0.0748939933534364 no 284 0.0753058496242096 413 6502001
SGTC_2749 bexarotene 57.39 µM 1.43402132219924 0.0753689745137436 no 285 0.075783089115621 469 82146 An retinoic acid receptor inhibitor.
SGTC_827 3253-0474 693 µM 1.43158692021073 0.0757152785410079 no 286 0.0761310375589149 489 5402065
SGTC_3296 9122258 64.045 µM 1.43138289329213 0.07574435719658 no 287 0.0761602542128968 471 4730474
SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.41889733532075 0.077540079842331 no 288 0.0779644746451006 503 1273210
SGTC_3301 9125354 19.7965 µM 1.41748365751959 0.0777454210279009 no 289 0.0781707845365879 419 41905162
SGTC_2488 5268135 45.7 µM 1.41392496879531 0.0782641589974897 no 290 0.0786919669309675 574 1270356 YLR208W SEC13
SGTC_2675 theaflavin digallate 100 µM 1.41177529025787 0.0785787795659138 no 291 0.0790080681598401 475 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1418 3966-3099 2.4 µM 1.41146991005668 0.0786235517615664 no 292 0.0790530509443258 495 740335
SGTC_2098 5376439 882.5 nM 1.40906849823057 0.0789762999778695 no 293 0.0794074573150248 497 2844116
SGTC_446 go6976 132 µM 1.40833045982457 0.0790849523908674 no 294 0.0795166201036711 421 3501 A protein kinase C inhibitor.
SGTC_543 3844-1095 191 µM 1.40762481919264 0.0791889410936987 no 295 0.079621097114849 503 4230703
SGTC_2895 9054447 58.44 µM 1.40694868746444 0.0792886782293222 no 296 0.0797213024471369 422 2697450
SGTC_1979 st071809 45.3 µM 1.40379416067544 0.0797552640564538 no 297 0.0801900766587426 470 4976333
SGTC_771 0250-0039 27.3 µM 1.40313770375172 0.0798526210981686 no 298 0.0802878899283902 482 3005115
SGTC_1643 st009866 20.2 µM 1.39958831430645 0.0803805771337295 no 299 0.0808183176545786 422 3156273 YOR207C RET1
SGTC_2116 5511452 16.8835 µM 1.39449152824447 0.0811433087373773 no 300 0.0815846129987563 499 870744
SGTC_2059 5238311 157 µM 1.38759136058628 0.082184600769386 no 301 0.0826307568499541 466 703021
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.38565347653754 0.0824788460139181 no 302 0.0829263703049573 526 442882
SGTC_1140 3229-1848 2.98 µM 1.38326059607125 0.082843270630671 no 303 0.0832924877529483 460 2849525
SGTC_390 dec-rvkr-cmk 16.7 µM 1.38110947062099 0.0831719099291633 no 304 0.0836226520361683 517 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2727 riluzole 51.77 µM 1.38107058225954 0.0831778601268519 no 305 0.0836286298304492 432 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2483 5729050 27.16 µM 1.38033620444673 0.0832902852931728 no 306 0.0837415763224546 599 2865180
SGTC_1635 st007035 42.4 µM 1.3796810483383 0.0833906788716556 no 307 0.0838424352838634 698 3716403
SGTC_60 0986-0278 202 µM 1.37825876511743 0.0836089370511506 no 308 0.0840617047258473 362 3110598
SGTC_3082 9117008 49.47 µM 1.37674668426116 0.0838414456583251 no 309 0.084295289882152 493 41448529
SGTC_3342 9147791 14.508 µM 1.37112518427927 0.0847101082084035 no 310 0.0851679677278119 489 1838168
SGTC_3229 9132204 49.47 µM 1.37093456597615 0.0847396813796516 no 311 0.0851976774109559 432 17682924
SGTC_153 4077-0274 519.67 µM 1.37054419812012 0.0848002685366462 no 312 0.0852585442043035 450 3121976
SGTC_2142 5622915 118.518 µM 1.37014273117998 0.08486261220357 no 313 0.085321175560866 446 5322196
SGTC_3159 9100096 49.47 µM 1.36708134453432 0.0853391444502127 no 314 0.0857999050021777 485 25236875
SGTC_2546 rhodinyl acetate 100 µM 1.36552031598774 0.0855829028571506 no 315 0.0860447861013215 508 6708682
SGTC_740 k014-0057 261 µM 1.36414819416973 0.0857975932292703 no 316 0.0862604645975663 562 4012779
SGTC_3038 9091290 49.47 µM 1.36394883514114 0.0858288196442288 no 317 0.0862918346801888 508 25236843
SGTC_1111 tnp00062 510.699 nM 1.36160703574211 0.0861962622678033 no 318 0.0866609668260443 492 676306
SGTC_585 0kpi-0023 191 µM 1.35922388921642 0.0865713992124156 no 319 0.0870378267319279 462 64601
SGTC_3232 9132874 49.47 µM 1.35833721006262 0.0867112846232266 no 320 0.0871783541195856 479 3784940
SGTC_779 1360-0071 233 µM 1.3576781648263 0.0868153671487081 no 321 0.0872829141351863 558 7566
SGTC_504 lovastatin 124 µM 1.35474295571189 0.0872800564494875 no 322 0.0877497334163041 432 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1306 1185-0270 9.02 µM 1.352474271181 0.0876404949842441 no 323 0.0881118220211961 561 1548076
SGTC_3300 9124615 50.48 µM 1.3481837674655 0.0883251855245582 no 324 0.0887996420993107 496 24824903
SGTC_2937 9044753 11.33 µM 1.34812974667955 0.0883338316516221 no 325 0.0888083277041885 551 6465530 YGL099W LSG1
SGTC_2922 7999257 32.47 µM 1.34781455873732 0.0883842906430157 no 326 0.0888590170684561 456 2988377
SGTC_2854 9024559 71.43 µM 1.34486096068798 0.0888581814351117 no 327 0.0893350697218263 519 3163529
SGTC_2588 indole-3-carbinol 100 µM 1.34408625581253 0.0889827917670864 no 328 0.0894602480062216 567 3712 Induces cell cycle arrest.
SGTC_3330 9141424 71.43 µM 1.34405897525586 0.088987182181038 no 329 0.0894646584270362 557 27261020
SGTC_2113 5491891 107.031 µM 1.3416477116702 0.0893758777356823 no 330 0.0898551241971385 531 789979
SGTC_46 0329-0187a 2.197 µM 1.34134170468414 0.0894252962163448 no 331 0.0899047675933989 618 46494817
SGTC_650 1328-0195 38 µM 1.33956803932369 0.0897121339937642 no 332 0.0901929101796548 535 2780821
SGTC_3335 9143315 29.6265 µM 1.33955321170175 0.089714534801558 no 333 0.090195321903838 500 4899691
SGTC_2821 7996764 71.43 µM 1.32564085480266 0.0919882530785562 no 334 0.0924793434555102 552 2987135
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.32337169962063 0.0923631168601503 no 335 0.0928558991879982 559 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2596 sinensetin 100 µM 1.31810338849038 0.0932377973365476 no 336 0.0937345201757656 502 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_79 0052-0007 94.094 µM 1.31756060680796 0.0933282602130571 no 337 0.0938253900082061 548 2801472
SGTC_1007 4101-0031 70 µM 1.31538076971035 0.0936922165950498 no 338 0.0941909825730602 560 1146276
SGTC_2015 5119600 184 µM 1.31211122598888 0.0942400788226732 no 339 0.0947413043940273 536 2828786
SGTC_1138 3761-0006 1.03 µM 1.31138803524181 0.0943615790358241 no 340 0.094863349530861 502 12061087
SGTC_3167 9103034 49.47 µM 1.31049852529486 0.0945111802090078 no 341 0.0950136213885234 451 5127859
SGTC_1975 st070967 30.8 µM 1.30936707067076 0.0947017251407566 no 342 0.0952050201291502 593 261391
SGTC_1210 3013-0140 750 nM 1.30926051487963 0.0947196844640927 no 343 0.0952230599010704 550 905973
SGTC_1842 st055362 61.2 µM 1.30601823608682 0.0952673514260601 no 344 0.0957731780669885 585 676032
SGTC_1060 3448-7350 82 µM 1.30440022709239 0.0955415266324423 no 345 0.0960485789055048 587 570178
SGTC_2390 9097792 176.6 µM 1.30418516808202 0.0955780125355744 no 346 0.0960852278344837 503 4497149
SGTC_2354 9060492 162 µM 1.30124031806736 0.0960786538739838 no 347 0.0965881043475841 614 6471895
SGTC_486 niguldipine 82 µM 1.30115647920572 0.0960929351339603 no 348 0.0966024493192393 482 1236 A calcium channel blocker.
SGTC_2734 clemastine 41.6 µM 1.30112972996566 0.0960974919752278 no 349 0.0966070264889571 375 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_3036 9090181 49.47 µM 1.30000867493836 0.0962886111174785 no 350 0.0967989979820201 520 25236586
SGTC_835 0312-0010 67.2 µM 1.29260810304262 0.0975572851815903 no 351 0.0980733178256002 512 1626196
SGTC_1717 st033143 58.0435 µM 1.29190225994037 0.0976789246613897 no 352 0.0981954975035906 601 674616
SGTC_401 neomycin 50 µM 1.29189561481814 0.097680070357925 no 353 0.0981966482872131 507 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2869 9037858 32.47 µM 1.29180315018399 0.0976960133611195 no 354 0.0982126620782587 492 27187042
SGTC_2858 9025781 8.96 µM 1.29125222898804 0.0977910442385634 no 355 0.0983081148289258 683 4894980 YPL153C RAD53
SGTC_1343 1487-0095 224 µM 1.28678061661544 0.0985648809295228 no 356 0.0990853824200216 526 4560101 YGL055W OLE1
SGTC_763 3453-1109 128 µM 1.28577541170391 0.098739452532135 no 357 0.0992607269219525 565 1560353
SGTC_1531 st059297 52.4 µM 1.28467065208375 0.0989315744552112 no 358 0.0994536989857104 574 7566702
SGTC_3085 9117376 49.47 µM 1.28349246929172 0.0991367661507823 no 359 0.0996597981227423 557 16480349
SGTC_685 1278-0033 54.9 µM 1.27965013672786 0.0998081072133312 no 360 0.100334104288273 584 3590572
SGTC_2855 9016525 58.44 µM 1.27439290614321 0.100732034385704 no 361 0.101262102561801 567 43811474
SGTC_1553 gossypol 38.6 µM 1.26945472298884 0.101605557635186 no 362 0.102139464633292 424 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1410 3909-8106 77.9 µM 1.26775454188407 0.10190757825555 no 363 0.1024428102304 546 1039210
SGTC_90 0870-0863 4.608 µM 1.26583593308164 0.102249184513702 no 364 0.102785913710534 606 1738164
SGTC_644 1498-1197 63.3 µM 1.2642503800405 0.102532118520339 no 365 0.103070086646701 612 6741615
SGTC_3179 9107801 49.47 µM 1.26279401206988 0.102792501214586 no 366 0.103331608610993 564 4818259
SGTC_2903 5923464 63.88 µM 1.26131862183772 0.103056774510319 no 367 0.103597037308401 540 2876576
SGTC_1570 verbenone 133 µM 1.25761172248813 0.103722934636813 no 368 0.104266105906971 596 29025 A natural terpanoid with antifungal properties.
SGTC_1758 st042942 75.2445 µM 1.25752933835128 0.103737775143413 no 369 0.104281011142841 565 669317
SGTC_3172 9105863 49.47 µM 1.25701456528047 0.10383054017608 no 370 0.104374180721312 472 2348785
SGTC_556 4058-0063 51.5 µM 1.25649561635946 0.103924118609996 no 371 0.104468167136672 625 6615692
SGTC_1816 st051957 91.6 µM 1.25544340346795 0.104114044516556 no 372 0.10465892073416 566 674121
SGTC_269 exalamide 29 µM 1.25460931490806 0.104264777380149 no 373 0.10481031015848 558 3316 A derivative of salicylamide.
SGTC_355 1311-2252 105 µM 1.2524211517322 0.104660964349535 no 374 0.105208221451698 586 5338538
SGTC_1101 ebselen 5.29 µM 1.25017010705818 0.105069673243857 no 375 0.105618707071431 609 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_3182 9108849 49.47 µM 1.25012547587972 0.105077788325802 no 376 0.105626857409442 602 17133045
SGTC_1207 2099-0101 141 µM 1.248767053341 0.105325001112376 no 377 0.105875143813123 628 5837381
SGTC_2283 7944793 200 µM 1.24736577048884 0.105580454446076 no 378 0.106131705735219 589 2970533
SGTC_600 1495-0418 41.6 µM 1.2442457244976 0.106150846336345 no 379 0.106704569959032 556 5377768
SGTC_1711 st032263 62.8 µM 1.24071016916075 0.106799886305734 no 380 0.107356418143249 557 3958979
SGTC_2391 6285546 200 µM 1.23935072198525 0.107050207641957 no 381 0.107607821126519 619 846083
SGTC_102 gallobenzophenone 83.616 µM 1.23786657034668 0.10732397426329 no 382 0.107882769797006 613 70837
SGTC_2467 5474540 200 µM 1.23725466917449 0.107436992378287 no 383 0.107996275617492 587 5413519
SGTC_2905 7799065 20.05 µM 1.23282789462974 0.108257173146681 no 384 0.10881999088071 563 1296806
SGTC_3189 9110682 49.47 µM 1.23076931484491 0.10864011250208 no 385 0.109204577582568 584 17122418
SGTC_1699 st031318 29.054 µM 1.22689986172577 0.109362547397455 no 386 0.109930115275546 589 5340658
SGTC_1881 5652484 16 µM 1.22587985272271 0.109553558614314 no 387 0.110121945777626 592 2255129
SGTC_415 dibenzyl ketone 100 µM 1.22390929890163 0.109923251106445 no 388 0.110493222659469 628 7593
SGTC_364 0083-0097 67.7 µM 1.22381558555582 0.109940854792368 no 389 0.110510901746876 608 5207356
SGTC_2867 9039098 71.43 µM 1.22313610983442 0.110068552163412 no 390 0.110639145965522 611 6463460
SGTC_2146 5545642 200 µM 1.22183271166704 0.110313804255717 no 391 0.110885447748069 613 825326
SGTC_1289 0976-0073 69.1 µM 1.2196440130361 0.110726518756415 no 392 0.111299926994219 642 3391136
SGTC_726 3448-4391 34.2 µM 1.21859908456573 0.110923946660516 no 393 0.111498198340089 651 1356692
SGTC_810 3825-7150 143 µM 1.21766823051926 0.11110003370357 no 394 0.111675037244704 638 22330411 YGL099W LSG1
SGTC_1496 4469-0713 57.4 µM 1.21679372050268 0.111265644590325 no 395 0.111841354910116 610 746691
SGTC_660 4031-1742 102 µM 1.21181177054238 0.112212476210407 no 396 0.112792220797923 647 6738706
SGTC_1731 st035964 63 µM 1.20920216276887 0.112710730415943 no 397 0.113292593513232 588 6739575
SGTC_2490 carminic acid 95.39 µM 1.20813481579983 0.112914974256834 no 398 0.113497704885399 528 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.20083057732523 0.114319780396148 no 399 0.11490846405596 594 140250 A respiratory chain inhibitor.
SGTC_3051 9093778 49.47 µM 1.2005898854162 0.114366282933857 no 400 0.114955163238867 538 17217378
SGTC_2889 9059656 51.95 µM 1.19909990169867 0.114654452868081 no 401 0.115244551165355 662 3949838
SGTC_249 wiskostatin 11.211 µM 1.19659907593242 0.115139285198569 no 402 0.115731430414514 640 2775510 A n-wasp and actin depolymerizer.
SGTC_2571 chrysanthemic acid 100 µM 1.1950918535934 0.11543219179068 no 403 0.116025572238329 589 2743 An insecticide.
SGTC_2720 fluspirilene 36.88 µM 1.19487572242455 0.115474237089522 no 404 0.116067794762527 556 3396 An atypical antipsychotic.
SGTC_1113 artemisinin 1.17947 µM 1.19369828372197 0.115703482465172 no 405 0.11629800605171 656 2240 An anti-malaria and mitochondrial poison.
SGTC_2069 5228469 200 µM 1.19342898205279 0.115755960448126 no 406 0.116350705057674 587 2835210
SGTC_2273 7815444 169.05 µM 1.19294758434052 0.115849811043765 no 407 0.116444950842727 601 2824616
SGTC_3193 9111931 49.47 µM 1.19179476529702 0.116074777765195 no 408 0.116670864424537 628 17087244
SGTC_485 niflumic acid 177 µM 1.18462010005595 0.117481848198819 no 409 0.118083843087173 597 4488 A COX2 inhibitor.
SGTC_3115 9123671 49.47 µM 1.18066735118421 0.11826218702725 no 410 0.118867448166583 647 3286988
SGTC_1834 st055981 52.8 µM 1.17917078103824 0.118558589353532 no 411 0.119165089208065 659 471719 YDL150W RPC53
SGTC_813 k007-0158 173 µM 1.17774843566184 0.118840777337191 no 412 0.119448455516543 715 6523916
SGTC_1831 st055328 12 µM 1.17761574109325 0.118867127614587 no 413 0.119474915775013 660 1103068
SGTC_2271 7849410 118.62 µM 1.17512982627688 0.119361539581805 no 414 0.119971389771606 643 972430
SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.17325396622742 0.119735580035518 no 415 0.120346988267952 699 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2875 9039966 71.43 µM 1.17264425621645 0.119857332048986 no 416 0.120469247068777 594 6463691
SGTC_2958 9077254 16.72 µM 1.17003326528874 0.120379703777852 no 417 0.120993791124676 602 16457351
SGTC_1876 myriocin 605 nM 1.16751349981513 0.120885342914696 no 418 0.121501529884958 649 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1991 st073000 8.92 µM 1.16709741326475 0.120968982209864 no 419 0.121585516189755 699 4301969 YIL048W NEO1
SGTC_366 0181-0206 4.31 µM 1.16633662531788 0.12112201664373 no 420 0.121739185328634 679 274874
SGTC_1154 4088-0362 150 µM 1.16341714708328 0.121710540954852 no 421 0.122330147912819 716 6618304
SGTC_2597 laccaic acid a 100 µM 1.16320953868243 0.121752468180835 no 422 0.122372248686493 672 5491415 A textile dye.
SGTC_2177 5811945 192 µM 1.15887297754953 0.122630572179211 no 423 0.12325398256487 643 5343475
SGTC_396 dithiazanine 1.25 µM 1.15758022465543 0.122893197355679 no 424 0.123517691588167 623 10578 An antihelmenthic.
SGTC_159 3970-0959 50 µM 1.14581333242814 0.125301802421419 no 425 0.125936198713705 874 6615653
SGTC_2325 6158266 200 µM 1.14491858856098 0.125486289600105 no 426 0.126121441510707 634 3623240
SGTC_1209 2323-2347 50.3 µM 1.14263867934599 0.125957240617572 no 427 0.126594319618463 654 5412760
SGTC_3351 9150312 21.596 µM 1.14153904459491 0.126184827460243 no 428 0.126822836790119 677 4904905
SGTC_2247 cerulenin 830 nM 1.14091877193143 0.126313329084438 no 429 0.126951863433681 667 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_760 0568-0725 82.9 µM 1.14083848321202 0.12632996912791 no 430 0.126968571449208 717 3916171
SGTC_2766 oltipraz 83.91 µM 1.14014617219086 0.126473515741431 no 431 0.127112704293659 641 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2031 5180455 200 µM 1.13957314649027 0.126592415166058 no 432 0.127232089108955 643 29949
SGTC_686 1319-0111 510 µM 1.1387286324294 0.126767788696014 no 433 0.127408178274155 721 4562600
SGTC_908 3448-7491 47.7 µM 1.13349695640994 0.127857979151779 no 434 0.128502809303418 750 1203031
SGTC_935 2996-0153 430 µM 1.12817468469032 0.128973716090099 no 435 0.12962307646781 684 23738523
SGTC_2492 derrusnin 100 µM 1.12816517770961 0.128975715113039 no 436 0.129625083594337 610 1715307 Part of coumarin class of compounds.
SGTC_182 3448-4371 550.524 µM 1.12704008358104 0.129212439235427 no 437 0.129862767013298 724 3491403
SGTC_1392 3455-1037 33.9 µM 1.12547644299616 0.129541935111597 no 438 0.130193597045617 682 981132
SGTC_1891 st059073 26.2 µM 1.12461460715174 0.129723792833318 no 439 0.130376190582957 737 688754
SGTC_3240 9133527 49.47 µM 1.1223733400111 0.130197554648152 no 440 0.130851867481909 671 17617455
SGTC_2850 9015429 58.44 µM 1.12234792115628 0.130202934574139 no 441 0.130857269140153 637 6457570
SGTC_1853 st056710 91.2 µM 1.1219281172782 0.130291808732713 no 442 0.130946502257991 707 269167
SGTC_3109 9122853 49.47 µM 1.11627780864964 0.131492086341895 no 443 0.13215161876655 737 1234709
SGTC_1467 k284-1082 293 µM 1.11583305584388 0.131586886808592 no 444 0.132246800708656 741 3334705
SGTC_2428 5615643 7.78 µM 1.11439692281021 0.131893325147842 no 445 0.132554471439418 653 2253075
SGTC_1490 4089-0339 670 nM 1.11171919266929 0.132466006026896 no 446 0.13312945253931 664 742542
SGTC_3004 9076122 71.4286 µM 1.10846765892899 0.133163705673565 no 447 0.133829949443422 695 44782551
SGTC_2772 vinpocetine 57.06 µM 1.10818106697307 0.133225322351685 no 448 0.1338918128892 687 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1791 st048313 56.1 µM 1.10705582465996 0.133467436839276 no 449 0.13413489659416 641 1204976
SGTC_1607 st000305 50.6 µM 1.1065766201706 0.133570637436668 no 450 0.134238510112689 705 5457690
SGTC_3028 9087778 49.47 µM 1.10508372383512 0.133892496555336 no 451 0.134561656251894 682 17217395
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.10389356526965 0.134149468855955 no 452 0.134819655255346 716 688667
SGTC_3185 9108267 49.47 µM 1.10310938559382 0.134318969530521 no 453 0.134989832735214 693 4910486
SGTC_2626 ethyl orsellinate 100 µM 1.10189728884243 0.134581253861573 no 454 0.135253163701252 659 75653 A natural product.
SGTC_2380 9035439 200 µM 1.10037808845365 0.134910488161657 no 455 0.135583710681419 756 6462575
SGTC_879 0831-1030 162 µM 1.10037526861562 0.134911099777583 no 456 0.135584324734746 740 1549252
SGTC_886 0866-0150 153 µM 1.10011146592705 0.134968326343795 no 457 0.135641779340205 747 271463
SGTC_588 3970-1144 52.9 µM 1.09954993708228 0.135090193908205 no 458 0.135764132403575 725 1888707
SGTC_1795 st049545 62.3 µM 1.09807418037605 0.135410834320914 no 459 0.13608604937958 690 5291882
SGTC_2346 9031566 143.75 µM 1.0960556200853 0.135850254705986 no 460 0.136527217316646 723 4771086
SGTC_2880 9042983 58.44 µM 1.0960091466355 0.135860382997505 no 461 0.136537385861845 698 6464714
SGTC_2244 6635614 200 µM 1.09504421438466 0.13607079441896 no 462 0.136748633273407 557 836499
SGTC_1912 st060209 90.8 µM 1.09152560245953 0.13683994578727 no 463 0.137520836276941 666 688787
SGTC_1155 4088-0394 48.2 µM 1.09148025783441 0.136849877257521 no 464 0.137530807106571 706 2326248
SGTC_2985 9022375 71.43 µM 1.09104714032516 0.136944764346034 no 465 0.137626070185195 721 4939335
SGTC_2830 7992007 71.43 µM 1.09083152125188 0.136992018784824 no 466 0.137673511831482 681 1952075
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.09074976575688 0.137009938990454 no 467 0.137691503024789 659 279621
SGTC_1910 st062352 60.4 µM 1.0902443474744 0.137120758535344 no 468 0.137802761480233 694 2245730
SGTC_38 0929-0051 58.268 µM 1.0877158695069 0.137676079628023 no 469 0.138360279867693 770 1379719
SGTC_3221 9128209 49.47 µM 1.08654871015132 0.137932935969558 no 470 0.138618151353496 682 16460723
SGTC_2486 5283202 22.39 µM 1.08630945505238 0.137985629099544 no 471 0.138671052644001 674 1377751
SGTC_1921 5740136 50 µM 1.08523356824663 0.138222750231017 no 472 0.138909110116055 777 1774243
SGTC_422 cantharidin 155 µM 1.0806997641996 0.139225033365382 no 473 0.139915344013737 717 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1291 0993-0025 5.79 µM 1.0803657160938 0.139299076145033 no 474 0.139989678201572 747 4353356
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.07944172739757 0.139504020583084 no 475 0.140195428910811 708 6710655
SGTC_663 1486-0733 13.9 µM 1.07862429100823 0.139685502177205 no 476 0.140377624074851 760 722445 YPR165W RHO1
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.07665229319596 0.140123972029052 no 477 0.140817816417772 529 4000243
SGTC_807 1315-0151 48 µM 1.07593564893406 0.14028354787397 no 478 0.140978018604353 808 4011080
SGTC_1989 st071868 50.2 µM 1.07591199891369 0.140288816148911 no 479 0.140983307552591 743 16414057
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.07515623022576 0.140457241824623 no 480 0.141152393984524 786 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1205 4161-2785 76 µM 1.0728981743367 0.140961275002674 no 481 0.141658402642504 651 3498106
SGTC_345 1362-0200 395 µM 1.07085647216011 0.14141806960138 no 482 0.142116985107534 688 1419823
SGTC_527 4476-4215 268 µM 1.07042973077115 0.141513672019969 no 483 0.142212961411359 730 4418754
SGTC_941 3237-0776 460 µM 1.0667751785276 0.142334190733472 no 484 0.143036684818175 703 760008
SGTC_3256 9138902 49.47 µM 1.06626409102897 0.142449195934066 no 485 0.143152138590282 768 17228773
SGTC_3188 9110789 49.47 µM 1.06543783534129 0.142635253371475 no 486 0.143338921420767 737 849217
SGTC_695 3505-6186 243 µM 1.06428527042823 0.142895063948685 no 487 0.143599744288122 761 1819379
SGTC_1212 0520-0165 585 µM 1.06329292659236 0.143119013657004 no 488 0.143824565956985 712 5403258
SGTC_213 1246-0773 967 nM 1.05859768800861 0.144181837326252 no 489 0.144891520146576 773 6251622
SGTC_1501 4491-0275 38.4 µM 1.05857907661712 0.144186060799038 no 490 0.144895760008163 760 5104718
SGTC_2936 9038235 15.59 µM 1.0582729779244 0.14425553557317 no 491 0.144965504344284 715 4749415
SGTC_2073 5212005 126 µM 1.05761047978935 0.144405979072192 no 492 0.145116531379354 656 691789
SGTC_1404 3909-7820 48.3 µM 1.05372901072376 0.145289527131033 no 493 0.146003501431996 737 23741373
SGTC_1381 2324-0066 62.1 µM 1.04992444100296 0.14615909306235 no 494 0.146876426728913 707 10885928
SGTC_1382 3002-2117 298 µM 1.04967686691108 0.146215799058448 no 495 0.146933351503885 797 1497314
SGTC_1555 citronellol 128 µM 1.04938820739782 0.14628193418419 no 496 0.146999741742217 727 8842 A terpine precursor.
SGTC_2242 6630449 61.2675 µM 1.04896657261409 0.146378571527462 no 497 0.14709675177148 648 691249 YDR170C SEC7
SGTC_1976 st070609 63.5 µM 1.04682324753466 0.146870477416579 no 498 0.147590553112134 778 682556
SGTC_2539 epi(13)torulosol 80 µM 1.0414523070094 0.148108006131645 no 499 0.148832838532078 713 6708597
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.04021271972523 0.148394610030815 no 500 0.149120541641841 672 6857784
SGTC_99 0109-0120 622.8 µM 1.03913028201737 0.148645182696462 no 501 0.149372074585433 723 759414
SGTC_1215 3852-0577 11.2 µM 1.03853358699939 0.148783432030763 no 502 0.149510853441006 833 2884876
SGTC_283 0987-0079 11.7 µM 1.03755315784973 0.149010775956936 no 503 0.149739067679895 812 411556
SGTC_2956 9076196 2.52 µM 1.03492491157741 0.149621363471171 no 504 0.150351989815272 763 16423868
SGTC_1214 0358-0031 63.7 µM 1.03221945471618 0.150251629722574 no 505 0.15098466163208 745 4301366
SGTC_618 k072-0232 33.2 µM 1.03068435670844 0.15061003356053 no 506 0.151344431460997 742 5872756 YGL099W LSG1
SGTC_2306 7482397 179.52 µM 1.02973098050957 0.1508329074802 no 507 0.15156815411364 766 891448
SGTC_270 tamoxifen 5.46 µM 1.0282189485195 0.151186830240453 no 508 0.151923423539451 834 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2318 6029776 164 µM 1.02818302827369 0.151195244839207 no 509 0.151931870138806 767 818325
SGTC_2992 9074591 71.4286 µM 1.02765560201801 0.151318834440701 no 510 0.152055929660507 746 17741321
SGTC_1690 st023502 41.2 µM 1.02633340783165 0.151628953976804 no 511 0.152367227616738 755 24207482
SGTC_2741 miltefosine 3.04 µM 1.0227357869833 0.152474910155684 no 512 0.153216392990143 686 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1560 lithocholic acid 53.1 µM 1.02236354973483 0.152562617676905 no 513 0.153304432788881 704 9903 A bile acid which acts as a detergent.
SGTC_1347 1493-0251 600 nM 1.02180355887011 0.152694627247181 no 514 0.153436942315518 848 3986378
SGTC_309 k408-0051 1.48 µM 1.01935836099142 0.153271934019272 no 515 0.154016433273709 838 3640463
SGTC_3103 9120822 49.47 µM 1.01878201020716 0.15340821973425 no 516 0.154153234083064 808 17141819
SGTC_2709 st078560 56 µM 1.01711933420284 0.153801831004745 no 517 0.15454833187929 803 17250903
SGTC_1057 3448-5381 134 µM 1.00997204854066 0.155501440570865 no 518 0.156254340918537 808 5497911
SGTC_2172 5754775 163.918 µM 1.00829914497556 0.155901036296586 no 519 0.156655436677833 714 2263357
SGTC_2327 6189656 200 µM 1.00755912082015 0.156078016872531 no 520 0.156833081064953 786 5349088
SGTC_1310 1188-0297 994 nM 1.00720546430498 0.156162642381056 no 521 0.156918023863455 798 1588352
SGTC_2808 7946468 45.46 µM 1.00650871317046 0.156329454507371 no 522 0.157085461198673 815 2970879
SGTC_1218 1348-1416 30.7 µM 1.00307217631702 0.157153926709901 no 523 0.157913019092574 782 6787668
SGTC_2475 5812728 15.03 µM 1.0021698034084 0.157370891452025 no 524 0.158130794632968 846 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2929 9013348 24.6 µM 1.00166643102064 0.15749200681649 no 525 0.158252362385301 749 2995952
SGTC_354 2783-3500 4.88 µM 1.00113264773381 0.157620506185309 no 526 0.158381341549668 777 6740761
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.998903873033814 0.158157790362777 no 527 0.158920629930827 772 115019
SGTC_1655 st012546 55.1 µM 0.994151325609607 0.159307482660865 no 528 0.160074600432889 782 720985 YLR208W SEC13
SGTC_3243 9134147 49.47 µM 0.990630473140072 0.160162734938677 no 529 0.16093302604551 863 24282180
SGTC_503 tyrphostin 8 294 µM 0.990218154916056 0.160263087370431 no 530 0.161033750311658 811 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_623 k072-0108 16.9 µM 0.989710320487776 0.160386743565478 no 531 0.161157864539828 788 5382803
SGTC_36 0335-0881 14.2 µM 0.987773004931453 0.160859046656601 no 532 0.161631915575202 857 23828853
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.987531630412126 0.160917955512479 no 533 0.161691042279148 845 688751
SGTC_2170 morpholine 200 µM 0.987315977033833 0.160970598884006 no 534 0.161743880297242 827 121171 Reacts with secondary amines.
SGTC_1446 4239-0190 62 µM 0.986699123448684 0.161121241711527 no 535 0.161895079956294 851 1340085
SGTC_3134 9127454 49.47 µM 0.98665349834672 0.161132387545011 no 536 0.161906266979255 843 24262820
SGTC_1445 4239-0156 97.7 µM 0.983688196025207 0.161857865114696 no 537 0.162634422699371 901 4008346
SGTC_1929 genistein trimethyl ether 50.5 µM 0.978701112530456 0.163082774435017 no 538 0.163863841111996 836 136420
SGTC_1760 st045453 10.4495 µM 0.978055701588375 0.163241737119252 no 539 0.164023387792283 868 3323419 YIL048W NEO1
SGTC_3112 9123419 49.47 µM 0.977877341884219 0.163285684302985 no 540 0.164067496381441 866 17015854
SGTC_2353 9059630 146.67 µM 0.97651560156009 0.163621465526791 no 541 0.164404510155437 839 4779114
SGTC_3138 9097216 49.47 µM 0.969254522505846 0.16541948261549 no 542 0.166209106843255 911 25237486
SGTC_2275 7947463 200 µM 0.967752897541065 0.165792910025655 no 543 0.166583896462574 800 1225414
SGTC_889 0919-1524 82.7 µM 0.965617941255702 0.166324773116268 no 544 0.167117697165886 783 3905452
SGTC_2930 9013230 14.89 µM 0.964209796801976 0.1666761742508 no 545 0.16747037683789 878 2995857
SGTC_2884 9058502 51.95 µM 0.963201179547198 0.166928168010912 no 546 0.1677232866489 831 6471554
SGTC_2732 terfenadine 20 µM 0.9617657376956 0.167287223463011 no 547 0.168083646186181 810 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_587 k089-0003 57 µM 0.960095055081784 0.167705747403589 no 548 0.168503688484805 732 9659696
SGTC_990 3985-0011 41.3 µM 0.959527235654817 0.167848145670464 no 549 0.168646602935772 783 5399565 YGL099W LSG1
SGTC_2067 5224629 34.075 µM 0.955962294957533 0.168743942532128 no 550 0.169545642104967 802 2835000
SGTC_2081 5214970 32.255 µM 0.955099132137135 0.168961298895357 no 551 0.169763783909978 861 2063512
SGTC_3056 9094900 49.47 µM 0.952710671676761 0.169563683207516 no 552 0.170368342412037 826 25236784
SGTC_2916 7875993 68.79 µM 0.952454358527952 0.169628408714431 no 553 0.1704333013065 848 1299250
SGTC_2130 NSC 7 2.4545 µM 0.951860902943243 0.169778331974878 no 554 0.170583764992131 889 21448
SGTC_2651 TUB2.036 5 µM 0.95056374521836 0.170106325576803 no 555 0.170912940083485 1010 15992207 YFL037W TUB2
SGTC_1819 st053448 58.6 µM 0.949101504880876 0.170476547794346 no 556 0.171284494550285 850 2857616
SGTC_1745 st081495 74 µM 0.94735622312444 0.17091910774619 no 557 0.171728645175703 895 13842402 YBL026W LSM2
SGTC_1974 st069448 26.9 µM 0.9447314738876 0.171586061406845 no 558 0.172397992166589 848 6323587 YNR016C ACC1
SGTC_558 k064-0027 21.3 µM 0.943859477659972 0.171808004761659 no 559 0.172620730922902 873 5088526
SGTC_96 0929-0093 37.281 µM 0.943450746321295 0.171912099491342 no 560 0.172725198530415 832 6991579
SGTC_2355 9061122 103.12 µM 0.939861839344292 0.172827842433333 no 561 0.17364421688176 867 5302957
SGTC_1609 st001574 46.4 µM 0.938976090635908 0.173054326883797 no 562 0.173871510067802 867 3960012
SGTC_180 1486-1293 102.781 µM 0.938785026382375 0.173103206470562 no 563 0.17392056412472 881 4140536
SGTC_1240 0356-0016 42.1 µM 0.938583673000121 0.173154727820669 no 564 0.173972269347508 839 4305613
SGTC_724 3910-0327 137 µM 0.938226202906564 0.173246219633258 no 565 0.174064087613761 870 2885483
SGTC_3340 9146634 11.102 µM 0.937781863664027 0.173359987863399 no 566 0.174178261660856 856 4907387
SGTC_2278 7948257 134.34 µM 0.936961988168711 0.173570032879524 no 567 0.174389055563919 884 1247028
SGTC_1829 berberine 14.4 µM 0.935420395178281 0.173965414002203 no 568 0.17478584511854 866 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1654 st012436 41.8 µM 0.935228690613295 0.174014621566123 no 569 0.174835227856508 832 4323132
SGTC_2298 7976326 193.81 µM 0.933564758028713 0.174442098712989 no 570 0.175264225720309 803 2235818
SGTC_67 0335-0847 266 µM 0.930017830757217 0.175355556047865 no 571 0.176180926247354 976 4552207 YOR254C SEC63
SGTC_1964 st076914 61 µM 0.929279593534154 0.175546058458823 no 572 0.176372103938008 898 24208661
SGTC_2805 7950783 58.44 µM 0.929141837373091 0.175581621007068 no 573 0.176407792504219 907 1178958 YDL195W SEC31
SGTC_2024 5144227 134 µM 0.92775830441811 0.175939041179157 no 574 0.176766478487619 923 3475211
SGTC_2493 resveratrol 26.09 µM 0.926025960803863 0.176387221785437 no 575 0.177216244465112 815 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1507 4075-3230 155 µM 0.925825661622141 0.176439088424571 no 576 0.177268294440386 817 659771
SGTC_875 0709-0210 25.7 µM 0.924842538077375 0.17669380404514 no 577 0.177523910015573 954 6251364
SGTC_216 k038-0035 28.382 µM 0.922459401014992 0.177312210799489 no 578 0.178144498916512 846 4444231 YPR107C YTH1
SGTC_48 0382-0018 55 µM 0.921203753747758 0.177638591213262 no 579 0.178472029422173 859 762596
SGTC_1040 k898-0338 155 µM 0.920540256677751 0.177811207003822 no 580 0.178645253027595 951 20969351
SGTC_2048 5246248 200 µM 0.919782160803646 0.178008563138232 no 581 0.178843303715752 884 677046
SGTC_3018 9082602 49.47 µM 0.91975137405952 0.178016580810735 no 582 0.178851349596284 914 17332089
SGTC_2171 5739187 198.077 µM 0.919190442513485 0.17816270190651 no 583 0.178997984663749 839 2262761
SGTC_2785 7756463 72.73 µM 0.91686877586291 0.178768293268112 no 584 0.179605703807381 902 2201551
SGTC_2101 5377231 179.231 µM 0.910987301241353 0.180308228134496 no 585 0.181151032318 903 2844213
SGTC_848 0368-0089 85.6 µM 0.909706329240506 0.18064472318977 no 586 0.181488702706412 917 762535
SGTC_2581 avocatin a 64 µM 0.909027068314796 0.180823316060875 no 587 0.181667918906761 879 6710728 A skin care supplement.
SGTC_762 1165-0429 115 µM 0.906487965087996 0.181491882639136 no 588 0.182338816027095 907 5967793
SGTC_1887 st057648 70.8 µM 0.904881697950773 0.181915623851397 no 589 0.182764031977351 907 688672
SGTC_338 4055-0136 114 µM 0.903577634983487 0.182260096785295 no 590 0.183109702418223 905 2900563
SGTC_2139 5578692 56.4705 µM 0.901915513710611 0.182699742574958 no 591 0.183550874804449 877 650991 YMR113W FOL3
SGTC_2193 5925765 200 µM 0.901530276320462 0.182801735715392 no 592 0.183653221816476 899 877370
SGTC_1713 st033146 12.748 µM 0.90083434834585 0.182986075508154 no 593 0.183838200917859 904 674619
SGTC_559 1550-0661 158 µM 0.898674595872015 0.183558896366679 no 594 0.1844130061596 910 5830875
SGTC_1388 3346-4487 254 µM 0.898654718172699 0.183564173618896 no 595 0.184418301677851 960 3345614
SGTC_3143 9086658 49.47 µM 0.895981883958092 0.184274634844737 no 596 0.185131219412145 960 25236626
SGTC_1233 0325-0408 14.2 µM 0.895555635468867 0.184388093175661 no 597 0.18524506956261 920 12874
SGTC_1632 st005650 90 µM 0.895311026101804 0.184453222636453 no 598 0.185310423883645 873 2759605
SGTC_500 h-89 112 µM 0.894784717668308 0.184593405538269 no 599 0.185451090621912 967 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_959 1222-0044 107 µM 0.894699274521267 0.184616169675281 no 600 0.185473933309653 932 6083612
SGTC_3196 9111891 49.47 µM 0.893450531052848 0.184949064533072 no 601 0.185807976262925 923 18891510
SGTC_2262 9014885 67.46 µM 0.892311376051386 0.185253069986394 no 602 0.18611302919123 877 6457424
SGTC_3171 9103192 49.47 µM 0.89026261644301 0.185800601301935 no 603 0.186662444696756 957 13018434
SGTC_1883 5-benzylidenerhodanine 20 µM 0.889391358024828 0.186033749121007 no 604 0.186896393909167 954 1273210
SGTC_1850 st056238 17 µM 0.887295633130138 0.186595305272731 no 605 0.187459878016412 1004 5393177
SGTC_2140 5586273 200 µM 0.886404314588455 0.186834454703736 no 606 0.187699847531677 918 854421
SGTC_1977 st070720 65.3 µM 0.885639440782577 0.187039828945029 no 607 0.187905925572969 873 682188
SGTC_431 k089-0097 107 µM 0.882425591538647 0.187904296365324 no 608 0.188773350758892 955 5499420
SGTC_3098 9119039 49.47 µM 0.880058953698488 0.188542453774346 no 609 0.189413686758005 932 17161528
SGTC_3220 9131269 49.47 µM 0.879390367701521 0.188722977970814 no 610 0.189594826493589 934 17722206
SGTC_2246 7293507 91.5585 µM 0.878949869039316 0.188841974747124 no 611 0.189714228836702 986 887656
SGTC_2257 7960413 200 µM 0.878594043482502 0.188938131591554 no 612 0.18981071329986 977 2974689 YIL048W NEO1
SGTC_1349 flufenamic acid 69 µM 0.878521890395713 0.188957633624794 no 613 0.189830281767628 899 3371 A non-steroidal anti-inflammatory.
SGTC_895 0964-0006 13.7 µM 0.876350065301119 0.189545229795996 no 614 0.190419877807619 940 6738897
SGTC_3022 9087993 49.47 µM 0.876004482066434 0.189638832326402 no 615 0.190513798589704 959 17173644
SGTC_235 0330-0087 5 mM 0.87563153263958 0.189739878988791 no 616 0.190615188714727 974 46494818 YHR062C RPP1
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.872883881022702 0.190485346061054 no 617 0.191363186481233 883 4620898
SGTC_2835 9006588 71.43 µM 0.872867124803286 0.190489897711427 no 618 0.19136775356622 865 2345538
SGTC_605 1315-0399 119 µM 0.872275179267442 0.190650736324845 no 619 0.191529137448036 980 24020461
SGTC_2145 5634607 200 µM 0.871501512300845 0.190861076428623 no 620 0.19174019024449 886 308662
SGTC_3260 9137109 49.47 µM 0.869522248852233 0.191399834822263 no 621 0.192280772072599 837 17478346
SGTC_1466 k213-0079 57.5 µM 0.867956135404256 0.191826792937209 no 622 0.192709173156256 963 3657981
SGTC_3329 9141233 27.5565 µM 0.866686843256299 0.192173258266928 no 623 0.193056808068902 949 4909101 YNL103W MET4
SGTC_399 oxolinic acid 75 µM 0.866085562790235 0.192337517014818 no 624 0.193221620892574 925 4628 A DNA gyrase inhibitor.
SGTC_687 k029-0044 34.9 µM 0.864619120495062 0.192738481943939 no 625 0.193623937212893 1005 5829338
SGTC_1709 st033179 39.1045 µM 0.862320691767158 0.193367961109608 no 626 0.194255534683776 972 573381
SGTC_1390 3413-2614 145 µM 0.860737153075977 0.193802379671561 no 627 0.194691412818786 999 3421432
SGTC_2335 9018011 154.17 µM 0.860300177190954 0.193922361687063 no 628 0.194811797619956 987 6458208
SGTC_2371 9071574 200 µM 0.858625572951967 0.194382582697454 no 629 0.195273562276816 944 45596039
SGTC_1862 st057513 3.81 µM 0.858115155503649 0.194522989650097 no 630 0.19541443975166 985 5393163
SGTC_2981 9013952 38.96 µM 0.857632180594631 0.194655904459005 no 631 0.195547799793631 921 2996344
SGTC_111 0083-0039 52.457 µM 0.85723843643389 0.194764303821821 no 632 0.195656562137581 880 759313
SGTC_470 aa-861 153 µM 0.857079944885606 0.194807947550314 no 633 0.195700351976232 958 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_808 0711-0032 135 µM 0.855986721796925 0.195109149771775 no 634 0.196002562040335 977 4252555
SGTC_1168 k815-0004 80.5 µM 0.855904648990731 0.195131773693431 no 635 0.196025261626468 952 642433
SGTC_1602 st001878 87.6 µM 0.855171246834207 0.195334011713861 no 636 0.196228175793416 956 595405 YLR310C CDC25
SGTC_646 4092-0839 27.3 µM 0.855063307249401 0.195363787150252 no 637 0.196258050744072 991 877796
SGTC_326 k292-0812 17.5 µM 0.85503817204064 0.195370721163666 no 638 0.196265007930792 970 3579357
SGTC_1355 1499-0035 1.68 µM 0.855032748526871 0.195372217360116 no 639 0.196266509127432 938 1548538
SGTC_1502 4534-4282 27.7 µM 0.854996186511671 0.195382303983797 no 640 0.196276629459358 930 3278949
SGTC_1079 idarubicin 2.36 µM 0.853820269524348 0.195706881258344 no 641 0.196602290887643 951 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3299 9121982 43.1275 µM 0.853801761258833 0.195711992535296 no 642 0.196607419228867 973 17594604 YPL160W CDC60
SGTC_1568 digitonin 820 nM 0.85363790743308 0.195757246245968 no 643 0.196652824010087 1003 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1810 st050138 53 µM 0.852206235897798 0.196152920314911 no 644 0.197049818086523 957 3444541
SGTC_3239 9133757 49.47 µM 0.851481599732687 0.196353374264252 no 645 0.197250940172843 982 17036923
SGTC_2400 5203494 178.7 µM 0.849791139511794 0.196821483724743 no 646 0.197720608335349 905 6777674
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.847920708658082 0.197340216040705 no 647 0.19824106536175 979 7104
SGTC_882 0843-0131 351 µM 0.847594833058003 0.197430676627177 no 648 0.198331826441828 1021 5425421
SGTC_154 3389-1638 511.116 µM 0.845813939453816 0.197925481954625 no 649 0.198828273979041 872 5238686
SGTC_1422 4031-0024 15.5 µM 0.843653661261828 0.198526700278168 no 650 0.199431484404022 969 782427
SGTC_757 1066-0008 322 µM 0.842072367735992 0.19896748125019 no 651 0.199873723591716 1001 6842497
SGTC_3106 9121286 49.47 µM 0.839681909539242 0.199634933101758 no 652 0.200543379865527 948 15943471
SGTC_348 k064-0012 10.7 µM 0.838891116535609 0.199856030623123 no 653 0.200765206639013 931 5066323
SGTC_260 nsc-65238 3.989 µM 0.834156709578593 0.201182799124544 no 654 0.202096341064226 961 3246252
SGTC_1181 1222-0449 220 µM 0.831994843636903 0.20179039202687 no 655 0.202705927511572 990 658318
SGTC_266 formosanin C 406 nM 0.83008202123657 0.202328906343461 no 656 0.203246205666343 997 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1730 st033808 45.1 µM 0.829932235389467 0.202371111608468 no 657 0.20328854904827 1049 1045166
SGTC_3279 9140807 49.47 µM 0.82683171183663 0.203245930266414 no 658 0.204166226587014 1024 45595718
SGTC_564 3555-0129 330 µM 0.825192275135828 0.203709411298933 no 659 0.204631219196192 920 563260
SGTC_2279 7948423 32.93 µM 0.824352779824682 0.203946986661381 no 660 0.20486956855406 989 1247112
SGTC_2357 9067248 200 µM 0.823792969853019 0.204105503393111 no 661 0.205028601406644 966 9150235
SGTC_2999 9069765 71.4286 µM 0.823356214164744 0.204229226816878 no 662 0.205152727494059 1041 2097066
SGTC_1878 temozolomide 1 mM 0.822332612706291 0.204519365866761 no 663 0.205443810222646 996 5394 DNA alkylating agent.
SGTC_1854 st056233 32.9 µM 0.821563038956715 0.204737662405168 no 664 0.205662816224286 978 5393174
SGTC_1367 1812-0510 76.9 µM 0.821523500349912 0.204748881629633 no 665 0.205674071898508 997 1142582 YDR527W RBA50
SGTC_2122 5258151 111.688 µM 0.819692978393898 0.205268699195815 no 666 0.206195576921894 976 2173356
SGTC_2314 7727897 200 µM 0.818500988388447 0.205607612454845 no 667 0.206535588943998 1020 900724
SGTC_3153 9100258 49.47 µM 0.816500998240134 0.206177006485154 no 668 0.207106826414314 948 25236848
SGTC_978 1416-0512 87.4 µM 0.813910387220783 0.20691593734026 no 669 0.207848144837537 1038 6814003
SGTC_339 3091-4833 71.4 µM 0.813080342108586 0.207153025732171 no 670 0.208085998151143 1004 3240077
SGTC_1198 1612-1005 86.7 µM 0.812445654112845 0.207334422020555 no 671 0.20826797930808 1053 6998509
SGTC_175 3793-3120 23.7 µM 0.811278803779229 0.207668157310237 no 672 0.208602789802444 1006 5322297
SGTC_1374 2889-5571 141 µM 0.81074383191321 0.20782127269323 no 673 0.208756398115776 1020 2853281
SGTC_3186 9110464 49.47 µM 0.810679132181483 0.207839795053024 no 674 0.208774980089725 1009 17018021
SGTC_970 1315-0089 19.5 µM 0.808745321385826 0.208393859926692 no 675 0.209330826662922 1001 6811083 YLR033W RSC58
SGTC_2103 5378138 10 µM 0.808173871656234 0.208557755176189 no 676 0.209495248371239 1094 244142
SGTC_277 nystatin 15.5 µM 0.807991275332712 0.208610140926615 no 677 0.209547802337867 1074 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2495 cafestol 54.53 µM 0.80657221482316 0.209017524887227 no 678 0.209956493533614 992 16667697 An anti-infammatory.
SGTC_899 1083-0020 478 µM 0.802326792448048 0.210239095295103 no 679 0.211181974036208 1026 767123
SGTC_421 streptovitacin 30 mM 0.802112958778085 0.210300734127432 no 680 0.211243809779726 1037 91467 include heat shock
SGTC_2593 nobiletin 86.24 µM 0.80199650182443 0.210334308002583 no 681 0.211277490894223 976 72344 An anti-infammatory.
SGTC_1258 0671-0043 57.1 µM 0.800746711059169 0.210694813615513 no 682 0.211639147314617 1054 4298767
SGTC_3074 9116018 49.47 µM 0.800734043523978 0.210698469455853 no 683 0.211642814818638 1021 17027303
SGTC_2285 7945142 200 µM 0.798631366701903 0.211305815857074 no 684 0.212252097099159 1006 2970608
SGTC_1955 wogonin 32.4 µM 0.798366638164759 0.211382353831128 no 685 0.212328878777629 1017 5281703 A flavanone.
SGTC_1479 0549-0158 134 µM 0.798352890670991 0.211386328932295 no 686 0.212332866534344 1108 5440202
SGTC_2431 5490079 200 µM 0.796611298360153 0.211890266050113 no 687 0.212838406789774 1093 5722345
SGTC_3292 9120825 59.784 µM 0.796237609191334 0.211998486101138 no 688 0.212946970789882 1066 24824900
SGTC_3039 9090270 49.47 µM 0.796198691328585 0.212009758537888 no 689 0.212958279046547 1044 17173750
SGTC_3130 9127414 49.47 µM 0.795274781937186 0.212277468917178 no 690 0.213226839752764 1074 1494646
SGTC_2933 9026794 32.47 µM 0.792050309063422 0.213213333269228 no 691 0.214165671193979 1024 17586027
SGTC_2665 lovastatin 100 µM 0.791038740136252 0.213507424033998 no 692 0.214460692589668 1062 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1880 MG-132 525 µM 0.790675199613853 0.213613172928402 no 693 0.214566775913636 1007 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1464 k208-0027 110 µM 0.789797374146058 0.213868645947966 no 694 0.214823056414269 1050 X1464
SGTC_1649 st011737 51.3 µM 0.788967540271494 0.214110315503617 no 695 0.21506548923734 1018 1761035
SGTC_3298 9116858 71.43 µM 0.788067600044108 0.214372581418762 no 696 0.215328582826688 1055 2506942
SGTC_3147 9097027 49.47 µM 0.786570832621081 0.214809191775589 no 697 0.215766569580473 1069 25236841
SGTC_3023 9089636 49.47 µM 0.785638854391159 0.215081312668884 no 698 0.216039547386817 1153 17249241
SGTC_2276 7947513 42.08 µM 0.785046405247197 0.21525440117546 no 699 0.216213180577485 1005 2105100
SGTC_2363 9053361 176 µM 0.784320999608909 0.215466443978209 no 700 0.216425890251134 1069 6469797 YMR079W SEC14
SGTC_2719 novobiocin 32.65 µM 0.784286229735021 0.215476610577157 no 701 0.216436088812887 1034 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2277 7947813 106.88 µM 0.784211639206338 0.215498421545799 no 702 0.216457968349722 1017 1246798
SGTC_1951 sophoraflavanone G 9.2 µM 0.782564657662281 0.215980340556643 no 703 0.216941401214126 1083 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1728 st035614 33.7865 µM 0.782481132675919 0.21600479721053 no 704 0.216965934633666 1053 15945546
SGTC_3117 9124945 49.47 µM 0.782346325820654 0.2160442729099 no 705 0.217005534228903 979 17592065
SGTC_766 1391-0721 126 µM 0.781534203849309 0.216282176243178 no 706 0.21724418390999 1077 1020919 YIL115C NUP159
SGTC_2639 lactacystin 53 µM 0.781367840610565 0.216330929466112 no 707 0.217293090013226 1061 3870 A proteasome inhibitor.
SGTC_2818 7996756 12.99 µM 0.780791191537455 0.216499967358634 no 708 0.217462657796038 1056 2241621
SGTC_304 1310-0298 97 µM 0.780289486205533 0.216647098528404 no 709 0.217610249958593 1051 1550234
SGTC_2910 7948405 25.97 µM 0.779471095199207 0.216887225686253 no 710 0.217851129034342 1047 2971328
SGTC_1272 0839-0021 27 µM 0.778941071099082 0.217042824089815 no 711 0.218007214369766 1062 5027250
SGTC_2526 patulin 37.61 µM 0.778238984313716 0.217249033969826 no 712 0.218214069204411 1090 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_274 sirtinol 40.1 µM 0.77806126461135 0.217301249957712 no 713 0.218266448440843 1095 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_711 k292-0785 179 µM 0.777936571724662 0.217337890414724 no 714 0.218303203435148 1117 4146315
SGTC_880 0833-0487 87.2 µM 0.776259560630619 0.21783101928978 no 715 0.218797872555516 1068 76075
SGTC_259 usnic acid 108.925 µM 0.775480753763401 0.218060248458039 no 716 0.219027816899618 1110 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2178 5812956 200 µM 0.774987307607332 0.218205558263932 no 717 0.219173579796589 1103 5403383
SGTC_1281 0884-0031 11.8 µM 0.774046206977804 0.218482847797137 no 718 0.219451733380474 1106 1548255
SGTC_3275 9138069 49.47 µM 0.772271486864802 0.219006309967631 no 719 0.219976824663225 1066 17617007
SGTC_1851 st056236 18.9 µM 0.77110898795285 0.219349585201419 no 720 0.220321166795702 1126 5393171
SGTC_1033 k072-0102 21.3 µM 0.769022379060795 0.219966516547893 no 721 0.220940012702051 1078 5965931
SGTC_2959 9079155 11 µM 0.768700866480543 0.220061664104453 no 722 0.22103545520858 1075 16189457
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.76797927081501 0.220275297095626 no 723 0.221249750126917 1108 23847180
SGTC_3005 9076496 71.4286 µM 0.767450953847848 0.22043178406984 no 724 0.221406721685804 1069 21368410
SGTC_3267 9137951 49.47 µM 0.766544070026665 0.220700550683563 no 725 0.221676320023075 1086 16643986
SGTC_739 1486-1183 203 µM 0.766197888371293 0.22080319552095 no 726 0.221779282320693 1100 4346692
SGTC_2587 piperic acid 92.2 µM 0.765540285207626 0.220998253879064 no 727 0.221974943675824 1030 5370536
SGTC_2505 galangin 7.89 µM 0.764558743857688 0.221289582220193 no 728 0.222267171936772 996 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.762340138953954 0.221948888385267 no 729 0.222928511693574 1086 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2656 pseudo-anisatin 100 µM 0.758485093002712 0.223097161804068 no 730 0.22408031690331 1104 6708809 A neurotoxin.
SGTC_715 0868-0130 184 µM 0.75608906596501 0.22381254952518 no 731 0.224797898559778 1107 2876258
SGTC_753 1322-0200 289 µM 0.755646351245172 0.223944874527059 no 732 0.224930628834068 1128 5403907
SGTC_1919 st067113 52.3 µM 0.754867415531866 0.224177802020575 no 733 0.225164269307105 1062 1268243
SGTC_1001 4048-4355 44.4 µM 0.754657404135875 0.224240625900502 no 734 0.225227285398593 1084 21824233
SGTC_1247 0448-0043 5.84 µM 0.753613967331731 0.224552913085817 no 735 0.225540527473611 1122 3089013 YGL099W LSG1
SGTC_303 1348-1668 34.2 µM 0.751350266876581 0.225231257065547 no 736 0.226220942420904 1100 5380509
SGTC_3158 9100007 49.47 µM 0.750870133497099 0.225375283627903 no 737 0.226365408124702 1100 19297233
SGTC_2700 st077718 96.8 µM 0.750186361775049 0.225580485971146 no 738 0.226571235792639 1088 904970
SGTC_1380 2291-0730 164 µM 0.749268640362637 0.225856063564803 no 739 0.226847652534377 1110 2999191
SGTC_1452 4194-0072 190 µM 0.748743039597991 0.22601397907675 no 740 0.227006048579205 1154 1343545
SGTC_1946 st076057 65.1 µM 0.747854853676219 0.226280974245443 no 741 0.227273855663881 1020 953009
SGTC_2718 lomofungin 53.02 µM 0.747782633016382 0.226302692133095 no 742 0.227295639564266 1114 5351222 A RNA synthesis inhibitor.
SGTC_2724 maprotiline 69.64 µM 0.747390591524718 0.226420605714325 no 743 0.227413911471569 1118 4011 A tricyclic antidepressant.
SGTC_127 0180-0333 59.125 µM 0.746547371076578 0.226674337068715 no 744 0.227668413435383 1117 771601
SGTC_509 pifithrin 175 µM 0.745832843584783 0.226889469290844 no 745 0.227884198554329 1164 4817 A p53 inhibitor.
SGTC_878 0828-0289 13.7 µM 0.745722123235665 0.226922815630231 no 746 0.227917646055628 1087 745350 YLR208W SEC13
SGTC_2027 5150920 200 µM 0.744513554706431 0.227286987476878 no 747 0.228282921988086 1122 786715
SGTC_2379 9035213 200 µM 0.74260252297944 0.227863500522088 no 748 0.228861180294986 1144 646551
SGTC_2570 licareol 100 µM 0.742345750814063 0.22794102526418 no 749 0.228938939483106 1062 443158
SGTC_2801 7907800 81.82 µM 0.741014185740696 0.228343289762131 no 750 0.229342419564601 1153 6620925
SGTC_925 2064-1272 59.6 µM 0.740617965632217 0.228463064442401 no 751 0.229462555887383 1064 6815817
SGTC_109 0132-0036 33.701 µM 0.740170092106895 0.228598496093711 no 752 0.229598396290078 1010 67274 A color developer.
SGTC_2723 salbutamol 83.58 µM 0.739941958905283 0.228667498202239 no 753 0.229667606589099 1077 9884233 β2-adrenoceptor agonist
SGTC_1465 k213-0056 144 µM 0.738982375371222 0.228957865819224 no 754 0.229958849793693 1053 24048857 YMR208W ERG12
SGTC_3007 9078383 71.4286 µM 0.737146408770769 0.229514000991425 no 755 0.230516659713574 1131 6496995
SGTC_2312 7706453 155.7 µM 0.736589827075085 0.229682745313437 no 756 0.230685911609202 1121 976098
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.733755451486232 0.230543147821688 no 757 0.231548897937817 1102 2374 Ca(2+)-ATPase inhibitor.
SGTC_1697 st025554 27.742 µM 0.732814318232924 0.230829235902497 no 758 0.23183584358819 1147 1269519
SGTC_529 4076-0302 30.3 µM 0.732423053342719 0.230948231920428 no 759 0.23195519607557 1084 5816522
SGTC_2680 butyl paraben 22.24 µM 0.732372335071934 0.230963659456452 no 760 0.231970669817088 1164 7184 An antifungal and steroid mimetic.
SGTC_955 1216-0110 33 µM 0.727634601644058 0.232407322609675 no 761 0.23341864671536 1104 3619719
SGTC_1909 st060837 51.5 µM 0.727197983308161 0.232540619320644 no 762 0.233552340724119 1094 678937
SGTC_1798 st045719 60.953 µM 0.726046091931702 0.232892488119032 no 763 0.233905257474133 1107 3980186
SGTC_2105 5350118 200 µM 0.724763506346729 0.233284627910558 no 764 0.234298563767501 1178 2133313
SGTC_1672 st016598 6.51 µM 0.724588542247973 0.233338150104974 no 765 0.234352245061545 1089 4665860 YNL267W PIK1
SGTC_2144 5628481 200 µM 0.722934470293795 0.233844473659298 no 766 0.234860072362638 1159 2818399
SGTC_2138 5575593 77.673 µM 0.72281567448499 0.233880861346251 no 767 0.234896568024786 1157 762213
SGTC_128 0906-2981 13.371 µM 0.720963645483924 0.234448551649782 no 768 0.235465941239315 1105 6740226
SGTC_522 1273-0010 11.6 µM 0.719797254206074 0.234806468824251 no 769 0.235824917882877 1214 5705015
SGTC_1764 st044502 93.5 µM 0.71811805329879 0.235322276035047 no 770 0.23634224979501 1169 8407
SGTC_104 0074-0074 590.992 µM 0.717253599320719 0.23558805769648 no 771 0.236608816109482 1034 3943124
SGTC_2931 9014674 55.67 µM 0.715214465871317 0.236215657261501 no 772 0.237238265846606 1167 2996810
SGTC_515 4092-1064 102 µM 0.714178171135252 0.236534958092529 no 773 0.237558506548896 1189 717353
SGTC_1078 idebenone 36.1 µM 0.714152004101101 0.236543023694113 no 774 0.237566595879311 1183 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_3088 9117578 49.47 µM 0.714080995699313 0.236564911747171 no 775 0.23758854832346 1226 678341
SGTC_1324 1418-0026 34.4 µM 0.71376694229618 0.236661730803214 no 776 0.237685652151008 1165 1372513
SGTC_2954 9074818 52.69 µM 0.711214475821353 0.237449434861497 no 777 0.23847566976673 1149 16648742
SGTC_3110 9122132 49.47 µM 0.710979579979067 0.237521997156801 no 778 0.238548444888705 1218 918317
SGTC_1606 st000094 49.2 µM 0.710789506687236 0.237580722107157 no 779 0.238607342044062 1202 1242210
SGTC_2188 6126565 140.678 µM 0.710355097477672 0.237714966871773 no 780 0.23874198034543 1128 874518
SGTC_75 0159-0059 199.013 µM 0.710291285465139 0.237734690097908 no 781 0.238761761375584 1178 5377270
SGTC_2686 alizarin 95.37 µM 0.709704366279566 0.237916139096698 no 782 0.238943741985052 1150 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1328 1441-0025 69.2 µM 0.708797849619602 0.238196542402199 no 783 0.239224966206172 1134 4562601
SGTC_3102 9121669 49.47 µM 0.708655821115583 0.238240490992727 no 784 0.239269043394307 1183 41905072
SGTC_2620 irigenin 100 µM 0.708340271507544 0.238338148982835 no 785 0.239366987075307 1198 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2619 obliquin 87.91 µM 0.707479309239706 0.238604715700364 no 786 0.239634333154422 1172 6708593 A bioactive alkalod. YER133W GLC7
SGTC_3173 9105693 49.47 µM 0.707476456526679 0.238605599213865 no 787 0.239635219249937 1228 17096658
SGTC_214 4373-3496 70 µM 0.706243997728985 0.238987471356111 no 788 0.240018206699652 1258 3779166
SGTC_1526 st051518 75 µM 0.704080757602439 0.239658549371448 no 789 0.24069124134994 1108 673993
SGTC_3033 9090887 49.47 µM 0.703557057698579 0.239821165479404 no 790 0.240854330951297 1192 19325384
SGTC_689 0833-0039 98 µM 0.702440766444052 0.240167990259863 no 791 0.241202164756692 1188 5374726
SGTC_3166 9102297 49.47 µM 0.700706637790386 0.240707315062258 no 792 0.241743056374895 1155 25237072
SGTC_442 cape 100 µM 0.697907387661845 0.241579288271682 no 793 0.242617556991895 1157 5281787
SGTC_2411 st077133 39.94 µM 0.697549180682634 0.241690994267066 no 794 0.242729586248664 1252 1403142 YNL221C POP1
SGTC_1086 cerivastatin 2.18 µM 0.697488923846183 0.241709787972935 no 795 0.242748434329317 1156 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2638 epoxomicin 18 µM 0.696332414378133 0.242070649239527 no 796 0.24311033901076 1183 9915668 A protesome inhibitor.
SGTC_2464 5717415 7.67 µM 0.695784303968731 0.242241776038526 no 797 0.243281960187038 1143 5285744
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.695652804798957 0.242282841444315 no 798 0.243323144187847 1275 688664
SGTC_3303 9125618 40.5795 µM 0.695539547975971 0.242318213036675 no 799 0.24335861791903 1216 22695467
SGTC_1244 0416-0015 52.5 µM 0.692885178411073 0.24314800829211 no 800 0.244190805909651 1201 96201
SGTC_2721 ifenprodil 61.44 µM 0.692053137293699 0.243408432606857 no 801 0.244451979829248 1204 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1344 1488-0097 29.1 µM 0.691907809695259 0.243453934805318 no 802 0.244497612935715 1188 747966
SGTC_2126 5251174 33.877 µM 0.691216491303995 0.24367045011021 no 803 0.244714750879861 1229 790722
SGTC_637 1181-0519 7.26 µM 0.689802613670397 0.244113588668926 no 804 0.245159162411277 1230 6252091 YGR060W ERG25
SGTC_344 k064-0035 6.43 µM 0.688885493818119 0.244401265263128 no 805 0.245447664406078 1178 5088750
SGTC_2452 5863136 48.41 µM 0.68867515354223 0.244467269269819 no 806 0.24551385768159 1182 2184096
SGTC_2001 4023502 57.655 µM 0.686096208026334 0.245277313079274 no 807 0.246326220989099 1206 108941 YCR052W RSC6
SGTC_1012 4112-3522 18 µM 0.685706442825723 0.245399863272922 no 808 0.246449121559463 1218 3112398
SGTC_14 0354-0009 295 µM 0.685476220590776 0.245472265333103 no 809 0.246521730554293 1248 1713507
SGTC_1992 st073643 23.3 µM 0.683616644031059 0.246057499812315 no 810 0.247108635905902 1216 3161292
SGTC_1171 0368-0077 21.4 µM 0.683582816536528 0.246068152720212 no 811 0.247119319198595 1195 3239779
SGTC_397 arbidol 50 µM 0.679975270344117 0.247205654950178 no 812 0.248260059753062 1242 131410 A RNA synthesis inhibitor.
SGTC_3092 9117248 49.47 µM 0.679806143047153 0.24725905171616 no 813 0.248313608234972 1262 17141857
SGTC_2127 5253358 187.912 µM 0.678047886029372 0.247814532655272 no 814 0.248870665875435 1169 20612
SGTC_2191 5911152 200 µM 0.677363470858662 0.248030937914721 no 815 0.249087684607166 1220 2875902
SGTC_2161 5662504 8.5105 µM 0.677223781687286 0.2480751186254 no 816 0.249131990508808 1198 2859334
SGTC_1753 st043925 64 µM 0.676287869450957 0.248371236000775 no 817 0.249428946494284 1235 670181
SGTC_383 2324-0395 7.37 µM 0.67621890175008 0.248393064445086 no 818 0.249450836724703 1226 3146421
SGTC_2347 9049783 174.81 µM 0.676090479703852 0.248433713058197 no 819 0.249491600383129 1223 6467988 YPL169C MEX67
SGTC_1085 doxorubicin 7.67 µM 0.675761191684765 0.248537956696586 no 820 0.249596138985347 1244 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1368 1852-0141 284 µM 0.675237926296814 0.248703656227828 no 821 0.24976230716448 1217 2838987
SGTC_1360 1598-0022 39.8 µM 0.675086880143102 0.24875149811054 no 822 0.249810284310587 1246 761525
SGTC_1896 st058441 89 µM 0.674984839629713 0.248783820874458 no 823 0.249842698448567 1184 688759
SGTC_2243 6634756 200 µM 0.674395738507833 0.248970470631176 no 824 0.250029875659237 1276 885676
SGTC_2248 tofa 1.1 µM 0.674295218726945 0.249002326581536 no 825 0.250061821598853 1184 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_51 1013-0126 23.419 µM 0.67408408618344 0.249069244133165 no 826 0.250128928153675 1314 1627850
SGTC_789 1309-1135 70.6 µM 0.673411979212702 0.249282329235781 no 827 0.250342614818979 1236 3092424
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.670194759121028 0.250303659161616 no 828 0.251366822180766 1218 61125 An anti-inflammatory.
SGTC_1193 1488-0126 41.5 µM 0.669838826982968 0.25041678855121 no 829 0.251480269695153 1259 1384710
SGTC_2006 4011487 200 µM 0.669511774914419 0.250520762592254 no 830 0.251584536010362 1261 45595294
SGTC_1025 k007-0731 70 µM 0.668436075046626 0.25086290263759 no 831 0.251927637109202 1216 6256118
SGTC_2198 6589944 200 µM 0.667765479563891 0.251076319169599 no 832 0.252141652563757 1200 5290268
SGTC_286 k060-0067 22.9 µM 0.666069570049282 0.251616469479155 no 833 0.252683316827817 1209 5985051
SGTC_519 k048-0011 62.8 µM 0.665776797340274 0.251709780219736 no 834 0.252776888827713 1248 6836379
SGTC_2598 perillyl alcohol 100 µM 0.665755654135108 0.251716519561178 no 835 0.252783647035389 1251 10819 An apoptosis inducer.
SGTC_2295 7971645 200 µM 0.665100743490838 0.251925317798383 no 836 0.252993029576321 1248 2978226 YKL099C UTP11
SGTC_1766 st045414 44.774 µM 0.663779544690653 0.252346819698072 no 837 0.253415709773903 1283 253960
SGTC_749 1000-0129 128 µM 0.663449324998916 0.252452227688642 no 838 0.253521412170974 1308 708470
SGTC_1023 4482-3888 16 µM 0.663255872649889 0.252513989547656 no 839 0.253583346483909 1252 3303168
SGTC_107 0358-0022 2.6945 µM 0.663174230298187 0.252540057184234 no 840 0.253609486896911 1240 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2337 9009472 200 µM 0.662494031628379 0.252757293336318 no 841 0.253827329289247 1286 5742383
SGTC_2426 5582046 32.21 µM 0.661888244408087 0.252950847387491 no 842 0.254021423120688 1259 2251934
SGTC_496 calpeptin 138 µM 0.660768625924005 0.253308779992574 no 843 0.254380353002769 1211 73364 A calpain inhibitor.
SGTC_845 0330-0138 4.51 µM 0.660404779608925 0.253425155895853 no 844 0.254497052897228 1228 9039800
SGTC_2540 epiandrosterone 100 µM 0.658975217881782 0.253882671819551 no 845 0.254955841325513 1326 441302 A steroid.
SGTC_1470 k295-0292 231 µM 0.65758622016766 0.254327620557994 no 846 0.255402025746167 1297 5045612
SGTC_3272 9137413 49.47 µM 0.655514112860744 0.254992154235397 no 847 0.256068401492762 1212 17614870
SGTC_32 0928-0142 34.1 µM 0.65443848894041 0.255337469278927 no 848 0.25641467211866 1227 2244242
SGTC_839 0122-0028 230 µM 0.654065072678775 0.255457406835931 no 849 0.256534941316719 1270 759448
SGTC_551 k048-0028 34.9 µM 0.653370684935099 0.255680515453501 no 850 0.256758666499422 1262 6836383
SGTC_1648 st011736 69.8 µM 0.65229670889784 0.256025787072815 no 851 0.257104891371913 1295 2855514
SGTC_2037 5169046 200 µM 0.651897951381365 0.256154045170506 no 852 0.257233503292555 1276 5718022
SGTC_130 0136-0219 337.655 µM 0.651509242603514 0.256279103390209 no 853 0.257358906360629 1225 234244
SGTC_337 1315-0038 354 µM 0.650103146269117 0.256731748602265 no 854 0.257812798528721 1262 1626437
SGTC_287 k060-0039 29.6 µM 0.649734338067298 0.256850542806752 no 855 0.25793191967467 1301 5861974
SGTC_973 1325-0077 65.9 µM 0.649428536012119 0.256949064235625 no 856 0.258030712151559 1300 2835149
SGTC_2087 5276107 200 µM 0.647642768685548 0.257524784194717 no 857 0.258608014205729 1247 144405
SGTC_1493 4348-0038 111 µM 0.645738118336705 0.258139568872291 no 858 0.259224484933886 1320 800424
SGTC_1656 st012921 11 µM 0.645046529430994 0.258362988706455 no 859 0.259448516629809 1233 6732821
SGTC_1 0258-0098 57.368 µM 0.6423771900223 0.259226265410138 no 860 0.260314153170989 1201 6790032 YDR047W HEM12
SGTC_844 0330-0132 15.3 µM 0.641739814472525 0.259432615879097 no 861 0.260521066693148 1267 2828079
SGTC_999 SEC7.066 22.7 µM 0.639118890187136 0.260282031579381 no 862 0.261372795977981 1298 740511 YDR170C SEC7
SGTC_2827 7993847 71.43 µM 0.638856463353609 0.260367160381978 no 863 0.261458156280696 1263 2985692
SGTC_1716 st033144 30.6155 µM 0.634389146735625 0.261818513002959 no 864 0.26291344540757 1308 674617
SGTC_318 1488-0629 67.2 µM 0.632982975709491 0.262276210410839 no 865 0.263372380188542 1284 3662576
SGTC_3327 9140648 26.9345 µM 0.63271324101384 0.262364053720574 no 866 0.263460460758919 1276 8029710
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.632350704770306 0.262482143030703 no 867 0.263578868910348 1306 6708784 An antioxidant flavonoid
SGTC_1386 3228-0095 33.8 µM 0.631319952408534 0.262818039669737 no 868 0.263915671766256 1304 870181
SGTC_1358 1509-0022 2.48 µM 0.630241981649713 0.263169558627829 no 869 0.264268137972612 1312 3258434
SGTC_1489 4065-0444 182 µM 0.629650186658424 0.263362641039946 no 870 0.264461740203883 1262 2877968
SGTC_1300 1094-0077 113 µM 0.627534544088611 0.264053493653906 no 871 0.265154449921776 1259 5532636
SGTC_199 4063-0024 41.6 µM 0.626561243090363 0.26437163011531 no 872 0.265473440095035 1318 306215
SGTC_2005 4024620 188 µM 0.626558187218743 0.264372629275039 no 873 0.265474441934515 1295 236743
SGTC_3194 9111903 49.47 µM 0.626415167991677 0.264419393550625 no 874 0.265521331621797 1337 17087251
SGTC_2451 5856223 45.7 µM 0.626072230549997 0.264531544021506 no 875 0.265633782773823 1275 2179896
SGTC_1630 st005209 31.3 µM 0.625013816749271 0.264877828523905 no 876 0.265980994950455 1317 3367314
SGTC_31 0508-1974 57.237 µM 0.624864753406948 0.264926616539741 no 877 0.266029913577401 1258 6810525
SGTC_1444 4112-3581 28 µM 0.623715551963527 0.265302900223192 no 878 0.266407203877897 1323 2877249
SGTC_1694 st024011 44.9 µM 0.623704963286333 0.26530636854077 no 879 0.266410681467688 1352 2787533
SGTC_3192 9110362 49.47 µM 0.623556898335158 0.265354869575694 no 880 0.266459312153846 1368 16649480
SGTC_2712 st079126 47.7 µM 0.623177900768741 0.265479036768414 no 881 0.26658381116704 1271 3152970
SGTC_1733 st037357 54.9 µM 0.622872097154522 0.265579245640613 no 882 0.266684287730618 1252 1272339 YGL099W LSG1
SGTC_2601 securinine 100 µM 0.622852989302939 0.265585507734639 no 883 0.266690566549716 1275 442872 A GABA receptor antagonist.
SGTC_2826 7992541 19.48 µM 0.622494798041111 0.265702909325098 no 884 0.266808281634524 1366 2985066
SGTC_2759 disulfiram 3.38 µM 0.62140410096918 0.266060560676323 no 885 0.267166887229701 1270 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_659 k018-0002 107 µM 0.621181199976471 0.266133682314366 no 886 0.267240203817304 1284 6797879 YHR007C ERG11
SGTC_3079 9117512 49.47 µM 0.621032730403848 0.266182392715467 no 887 0.26728904405784 1346 7185044
SGTC_2036 5160441 105 µM 0.619622942884942 0.266645145392896 no 888 0.267753029129981 1345 134534 YIL048W NEO1
SGTC_152 4469-0003 551.229 µM 0.619192664091887 0.26678646229986 no 889 0.267894721996468 1304 697280
SGTC_113 0099-0221 2.5 µM 0.618291922553633 0.267082416267981 no 890 0.268191462724701 1381 89219
SGTC_2481 5478948 45.16 µM 0.61821269575619 0.267108455510295 no 891 0.26821757115079 1323 77792
SGTC_1905 st060207 84.5 µM 0.617920688052698 0.26720443990372 no 892 0.268313810511648 1254 1948547
SGTC_1790 st045711 43.5 µM 0.617772423167418 0.267253181976093 no 893 0.268362682027192 1354 585119
SGTC_3120 9124077 49.47 µM 0.613714024372531 0.268589120275167 no 894 0.269702159633926 1349 18774327 YGL155W CDC43
SGTC_943 3253-1379 105 µM 0.612990963407192 0.26882748829336 no 895 0.269941157435551 1355 668464
SGTC_607 4491-0986 66.8 µM 0.611873393345458 0.269196121109809 no 896 0.270310763174574 1368 698981 YDR232W HEM1
SGTC_193 1273-0060 1.558 µM 0.610693450756935 0.269585602646344 no 897 0.270701271301989 1212 2847393 YHR072W ERG7
SGTC_2125 5246583 200 µM 0.610231642021092 0.269738115698148 no 898 0.270854185966061 1367 835267
SGTC_106 0092-0003 11.579 µM 0.609686169090848 0.269918314625756 no 899 0.271034859135634 1326 1072148
SGTC_1803 st050068 52.4 µM 0.607474243048196 0.270649649307688 no 900 0.271768115459538 1404 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2094 5332512 191.667 µM 0.605874974950641 0.271179035051718 no 901 0.272298889143621 1401 755774
SGTC_427 1354-0053 47.3 µM 0.605049072356175 0.271452625280998 no 902 0.272573195661615 1412 6813657
SGTC_784 4579-0127 173 µM 0.600877286642022 0.272836677764985 no 903 0.27396086121923 1464 1948547
SGTC_888 0916-0002 6.97 µM 0.60075808156467 0.272876277216999 no 904 0.274000563787225 1385 2802138 YIL048W NEO1
SGTC_456 gingerol 170 µM 0.599577799278277 0.273268516060819 no 905 0.274393823234765 1383 442793 A herb.
SGTC_1562 morin hydrate 59.1 µM 0.595150256193485 0.274742389287817 no 906 0.275871518871905 1369 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_186 3455-3465 67.277 µM 0.594396640418069 0.274993648260698 no 907 0.276123427486325 1295 755278
SGTC_2409 alverine citrate 63.97 µM 0.59424591607822 0.275043914031658 no 908 0.27617382315235 1469 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1071 trifluoperazine 6.31 µM 0.593676149144801 0.275233969174839 no 909 0.276364369220403 1405 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_3169 9102970 49.47 µM 0.593537338772274 0.275280281452503 no 910 0.276410801075612 1394 17027839
SGTC_841 0251-0215 91.2 µM 0.592061027681684 0.275773070666838 no 911 0.27690486144799 1383 3888614
SGTC_1059 3448-6867 171 µM 0.591642899996629 0.275912719457364 no 912 0.277044870060834 1339 3934407
SGTC_781 4335-2806 94.4 µM 0.591537138493735 0.275948047821801 no 913 0.277080289424878 1464 845254
SGTC_183 3914-0051 30.55 µM 0.591528948243959 0.275950783769419 no 914 0.277083032419335 1375 1596232
SGTC_2733 amorolfine 100 µM 0.590295222599987 0.276363061111897 no 915 0.27749637086081 1396 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.589709537346174 0.276558886800345 no 916 0.277692700011121 1326 75037 A free radical scavenger.
SGTC_2222 6885208 172.143 µM 0.58918536655279 0.276734202597934 no 917 0.277868466242755 1322 609514
SGTC_1796 st049173 110.4 µM 0.588744795370399 0.276881599512803 no 918 0.278016241642983 1316 94134
SGTC_1202 1988-0068 29.6 µM 0.588089817691743 0.277100799021594 no 919 0.278236003644276 1301 2850480
SGTC_1855 st056195 39.6 µM 0.58801049552616 0.277127351308095 no 920 0.278262624037335 1382 4028379
SGTC_638 3970-0837 4.09 µM 0.58744907761198 0.277315315813603 no 921 0.278451070487107 1345 4118451 YLR208W SEC13
SGTC_12 0849-0099 9.267 µM 0.586963051498435 0.277478089237463 no 922 0.278614261003948 1351 6071388
SGTC_3308 9128332 17.569 µM 0.586600936545174 0.277599394327631 no 923 0.278735876770568 1429 17332805 YDL196W YDL196W
SGTC_188 3229-0966 278.469 µM 0.586211142366966 0.277730000646431 no 924 0.278866817437015 1462 5722370
SGTC_49 0717-0965 32.132 µM 0.586130489532105 0.277757028321192 no 925 0.27889391428222 1430 5889349 YGL099W LSG1
SGTC_1530 rhein 70.4 µM 0.586110089938042 0.277763864658795 no 926 0.278900768114628 1379 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1959 st077091 55.8 µM 0.585109222002697 0.278099377651207 no 927 0.279237139190376 1357 821356 YKL052C ASK1
SGTC_3290 9121031 71.43 µM 0.584315513494197 0.278365586708331 no 928 0.279504028352506 1333 17014854
SGTC_244 nsc-207895 1.295 µM 0.583468764571549 0.278649722322381 no 929 0.279788889155798 1278 42640
SGTC_3067 9117431 49.47 µM 0.58253081036406 0.278964627607132 no 930 0.280104597300788 1355 17150885
SGTC_1990 st072050 59.8 µM 0.582070541749144 0.279119219785168 no 931 0.280259583284756 1353 17233948
SGTC_2225 6654152 15.4 µM 0.580974141529217 0.279487639609958 no 932 0.280628940737493 1352 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_671 0560-0003 407 µM 0.580346476631407 0.279698658056192 no 933 0.280840495667367 1349 3238678
SGTC_2662 daunorubicin 22.37 µM 0.580264532445342 0.279726213070953 no 934 0.280868120706739 1328 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1792 st045773 43.6 µM 0.57868861513907 0.280256396024735 no 935 0.281399649647116 1346 2919270
SGTC_2041 5107442 45.335 µM 0.577097064430956 0.280792332042499 no 936 0.281936943650708 1373 793005
SGTC_1578 josamycin 24.2 µM 0.576771483095942 0.280902028763556 no 937 0.282046918004726 1309 5282165 A P450 substrate.
SGTC_2301 7769476 200 µM 0.574749334720806 0.281583806011436 no 938 0.282730418312146 1431 977820
SGTC_1458 k015-0034 6.33 µM 0.574431022445271 0.281691199214866 no 939 0.282838082544736 1318 3598957
SGTC_1129 3453-1384 223 µM 0.573624573144518 0.281963369990378 no 940 0.283110939729235 1455 1084452
SGTC_3090 9117696 49.47 µM 0.571984033866163 0.282517430692946 no 941 0.283666395675579 1440 7923821
SGTC_526 4469-0568 170 µM 0.571739705204022 0.282599992781973 no 942 0.283749165434241 1367 2901964
SGTC_1039 k821-0043 94 µM 0.571212735327296 0.282778102782249 no 943 0.28392772322576 1392 15992768
SGTC_39 0986-0283 58.349 µM 0.570383767479732 0.28305839385404 no 944 0.284208718399918 1454 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_741 4582-0002 126 µM 0.569076568305791 0.28350065550187 no 945 0.284652089571695 1353 2912688
SGTC_2331 7980721 200 µM 0.568880894881428 0.283566885720606 no 946 0.284718485792186 1407 2981221
SGTC_2378 9074213 121.43 µM 0.567680852079216 0.283973230171207 no 947 0.285125847844825 1356 657714
SGTC_3235 9132602 49.47 µM 0.566893446200556 0.284240003633023 no 948 0.28539328856605 1415 4912240
SGTC_1954 st077032 68.9 µM 0.565799099479018 0.284610967639951 no 949 0.285765179359581 1306 698907
SGTC_2342 7990637 118.86 µM 0.563749651824413 0.285306315009692 no 950 0.286462260556587 1429 2033102 YER133W GLC7
SGTC_2814 7977482 42.97 µM 0.563607381401703 0.28535461529032 no 951 0.286510681109135 1486 6456762
SGTC_2833 9001315 45.46 µM 0.562751433985397 0.2856452884325 no 952 0.286802077604859 1436 2989378
SGTC_229 benomyl 22.8748 µM 0.561573149662992 0.28604565501361 no 953 0.287203439258964 1378 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1754 st042065 16.137 µM 0.561126093918911 0.286197628829053 no 954 0.287355790409313 1333 1126236 YIL048W NEO1
SGTC_1137 ixabepilone 100 µM 0.558620054181009 0.287050250640863 no 955 0.288210525298779 1368 154225 A novel microtubule stabilizer.
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.558404891355658 0.287123510832678 no 956 0.288283966745323 1418 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1186 1319-0216 26 µM 0.556446711287101 0.287790652665346 no 957 0.288952756925623 1484 4565136
SGTC_2517 totarol 10 µM 0.555037587161626 0.288271186590264 no 958 0.289434475630645 1346 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_162 k030-0015 37.8 µM 0.554972303528825 0.288293458524751 no 959 0.289456802426849 1481 1809920 YMR134W ERG29
SGTC_1978 st071761 42 µM 0.554895823660006 0.288319551159831 no 960 0.289482959329325 1360 5147680
SGTC_131 0141-0277 33.849 µM 0.554121614715442 0.288583750680127 no 961 0.289747809237437 1462 1547771
SGTC_1911 st060208 74.3 µM 0.554088728191823 0.288594975761647 no 962 0.289759061938042 1481 688783
SGTC_112 phenothiazine 287.218 µM 0.549329032567837 0.290221756643582 no 963 0.291389833391987 1435 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1117 retinoic acid 1.10837 µM 0.548617193594591 0.290465419578283 no 964 0.291634091976632 1515 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1143 3454-2408 5.08 µM 0.547538017384243 0.290835004799857 no 965 0.292004579645914 1373 X1143
SGTC_1723 st034307 2.5525 µM 0.547536644096248 0.290835475249491 no 966 0.292005051243496 1431 867466
SGTC_759 3486-0358 89.3 µM 0.547485679241743 0.290852934619085 no 967 0.292022553214414 1490 875103
SGTC_535 2293-4129 48.2 µM 0.547407335836098 0.290879774196653 no 968 0.292049458275873 1475 396118 YIL048W NEO1
SGTC_87 0100-0052 35.5 µM 0.546874929874667 0.291062201202425 no 969 0.292232330198713 1482 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1091 telmisartan 47.6 µM 0.546316382483483 0.291253642898587 no 970 0.292424238473294 1479 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2803 7707263 71.43 µM 0.544266293543841 0.291956812632173 no 971 0.29312911910974 1411 2199229
SGTC_1409 3909-8004 61.9 µM 0.540594142938508 0.293218313262728 no 972 0.294393677908755 1426 2119279
SGTC_2333 9017922 200 µM 0.539627865564921 0.293550679778057 no 973 0.294726847758753 1560 3163164
SGTC_1323 1348-1351 11.2 µM 0.538767306587046 0.293846829551727 no 974 0.295023712488269 1423 6989654
SGTC_2195 6536160 144.242 µM 0.538716931507806 0.293864169737406 no 975 0.295041094511501 1328 3834386
SGTC_700 3453-2283 142 µM 0.53641206995854 0.294658058391997 no 976 0.295836895707928 1505 565664
SGTC_2219 9098279 200 µM 0.535493315460701 0.294974790576172 no 977 0.296154389334213 1440 902349
SGTC_923 1900-2434 73.3 µM 0.533935594239904 0.295512158807359 no 978 0.296693047353449 1391 5910570
SGTC_363 0455-0021 3.06 µM 0.532216300064652 0.296105787069013 no 979 0.297288097402627 1458 4597466
SGTC_2450 5739737 12.93 µM 0.530980968611421 0.296532652941576 no 980 0.297715983684364 1427 2262825
SGTC_1610 st001799 48.1 µM 0.529983140990538 0.296877655638108 no 981 0.298061809895381 1392 621897
SGTC_2524 avocatin b 10.57 µM 0.529834318211995 0.296929127417226 no 982 0.298113404444391 1446 6710748
SGTC_599 1935-0052 86.5 µM 0.528028336601949 0.297554068542464 no 983 0.298739834262311 1417 9557311
SGTC_2762 leflunomide 42.06 µM 0.527678946520252 0.29767504062567 no 984 0.298861094109482 1466 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2141 5621638 7.665 µM 0.527617296123651 0.297696388657768 no 985 0.298882492909775 1526 2856238
SGTC_334 1502-1024 68.5 µM 0.526961120571367 0.297923649555169 no 986 0.299110294005847 1441 3296216
SGTC_2088 5278280 127.392 µM 0.525536008517412 0.298417497381046 no 987 0.29960531409888 1468 791502
SGTC_2842 9000675 19.48 µM 0.523580224363703 0.299095846165343 no 988 0.300285269518168 1387 2989072
SGTC_122 0236-0016 402.397 µM 0.522367645796556 0.299516770997843 no 989 0.300707189201583 1476 6808838
SGTC_1622 st003707 19.4 µM 0.522215202040567 0.299569708099564 no 990 0.300760251306327 1472 10140899
SGTC_1809 st050081 57.6 µM 0.521641317577315 0.299769031286893 no 991 0.300960044938589 1525 5036894
SGTC_3291 9121177 71.43 µM 0.521097192330429 0.299958073866505 no 992 0.301149533367482 1423 17015612
SGTC_236 1509-0011 5.31 µM 0.520452434011667 0.300182148677707 no 993 0.301374136232461 1474 3107280
SGTC_1994 st072947 40.9 µM 0.520347750178249 0.300218536908212 no 994 0.301410610172566 1479 5286565 YDL195W SEC31
SGTC_2252 omeprazole 400 µM 0.5203298878805 0.300224746064259 no 995 0.301416833952596 1475 4594 A proton pump inhibitor.
SGTC_2221 6807166 181.081 µM 0.517632788971909 0.301162956450615 no 996 0.302357250042864 1474 674925
SGTC_65 0798-0905 34.986 µM 0.517012949083044 0.301378759926986 no 997 0.302573559743623 1662 3602145
SGTC_143 4032-1194 15.74 µM 0.516268285032004 0.30163811420173 no 998 0.302833521847152 1459 1806963
SGTC_2862 9027634 71.43 µM 0.515311479960751 0.301971500977527 no 999 0.303167689065277 1397 5012562
SGTC_1634 st006576 41 µM 0.513329620688037 0.302662581005828 no 1000 0.303860383687771 1566 3915356
SGTC_914 3820-6779 408 µM 0.513011793309326 0.302773474227702 no 1001 0.303971535592584 1419 2893481
SGTC_773 4358-1457 44.6 µM 0.512376010115567 0.302995360073673 no 1002 0.304193938703645 1586 1186886
SGTC_1126 isoteolin 1.0172 µM 0.510956509858573 0.303491022497177 no 1003 0.304690755023968 1410 133323
SGTC_1245 0418-0076 17.2 µM 0.510285280153788 0.303725529162606 no 1004 0.304925806847175 1499 6790114
SGTC_2143 5623677 140.463 µM 0.509890949192269 0.303863333764071 no 1005 0.305063931572018 1460 5375313
SGTC_1619 st003326 88.7 µM 0.50905588303984 0.304155251609484 no 1006 0.305356526984674 1532 2849032
SGTC_2529 gangaleoidin 93.61 µM 0.508168984374911 0.304465425530325 no 1007 0.305667420005866 1506 4565183
SGTC_1628 st004252 77.7 µM 0.508129567693628 0.304479213941832 no 1008 0.30568124036401 1573 692968
SGTC_464 bw-b 70c 158 µM 0.506632840102123 0.305002992045102 no 1009 0.306206230751409 1520 5353454
SGTC_1565 sinapyl alcohol 95.1 µM 0.505932823907548 0.305248099179003 no 1010 0.30645190433737 1408 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2765 myclobutanil 7.74 µM 0.505055147232626 0.305555536656326 no 1011 0.306760051550099 1471 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.503072459244676 0.306250548277973 no 1012 0.307456664507338 1455 688664
SGTC_1642 st009582 77.7 µM 0.501099749209083 0.306942754888529 no 1013 0.308150461671042 1540 6739311
SGTC_1499 4480-0877 67.3 µM 0.499338867594041 0.307561214746469 no 1014 0.308770338981396 1470 2861909
SGTC_1771 st048882 4.1505 µM 0.499226281754469 0.307600775974094 no 1015 0.308809990762623 1418 4580403
SGTC_76 0433-0009 400.328 µM 0.497430978547492 0.308231924700257 no 1016 0.309442582252538 1489 2841569
SGTC_3254 9136651 49.47 µM 0.497057718468945 0.30836321764219 no 1017 0.309574174871388 1447 16454030
SGTC_1596 piperlongumine 63 µM 0.496721367349572 0.308481548985219 no 1018 0.309692776173649 1589 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2649 anisomycin 9.56 µM 0.496112648880394 0.308695752188963 no 1019 0.309907467737038 1455 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_774 k060-0086 136 µM 0.496043071885883 0.308720239929219 no 1020 0.309932011280371 1540 5911235
SGTC_737 1950-0117 57.9 µM 0.495942043226358 0.308755798650022 no 1021 0.309967651023391 1509 5393513
SGTC_1378 2093-0007 380 nM 0.492304236263107 0.310037377991836 no 1022 0.311252142919891 1519 3618014
SGTC_3222 9128301 49.47 µM 0.489802128573808 0.310920199497784 no 1023 0.312136962169347 1492 4911358
SGTC_2793 7325131 81.82 µM 0.488096035342321 0.31152278734012 no 1024 0.312740909593393 1544 4176441
SGTC_1917 st066507 28.5 µM 0.486910833479316 0.31194169515721 no 1025 0.313160760645477 1497 3156428
SGTC_1318 1280-3875 124 µM 0.486451484819851 0.312104116719989 no 1026 0.313323547501465 1503 373245
SGTC_683 panaxydol 45 µM 0.486179616153563 0.312200264251807 no 1027 0.313419911161724 1538 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2173 5763948 167 µM 0.484052749803604 0.312952880814129 no 1028 0.314174216651951 1502 2867177
SGTC_2870 9038528 12.99 µM 0.483839772483244 0.313028288356572 no 1029 0.314249793134422 1485 6463316
SGTC_2677 mitomycin C 100 µM 0.483243799977145 0.313239342159151 no 1030 0.314461319502237 1508 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2731 amoxapine 43.43 µM 0.482959612622874 0.313340003958543 no 1031 0.314562206550166 1581 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_53 0973-0023 39.979 µM 0.482814035447148 0.313391574133044 no 1032 0.314613892086816 1517 674768
SGTC_1072 oxiconazole 14.9 nM 0.4817627586382 0.313764093302506 no 1033 0.314987243870667 1533 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2196 6573537 42.6665 µM 0.480617251077846 0.314170219321624 no 1034 0.315394276200315 1595 2903087
SGTC_570 0987-0065 62.6 µM 0.479104902781353 0.314706749095233 no 1035 0.315932001025466 1481 3104428
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.477785585757351 0.315175117680158 no 1036 0.316401410731441 1471 4174840
SGTC_2890 9046729 58.44 µM 0.476674417493591 0.315569822376355 no 1037 0.316796991276626 1438 903329
SGTC_347 4534-1311 26.2 µM 0.47598697786315 0.315814117329122 no 1038 0.317041827619779 1488 2862016
SGTC_1206 3978-0017 132 µM 0.475660168442617 0.315930283601326 no 1039 0.317158251144366 1589 3873677
SGTC_1629 st005085 44.9 µM 0.474311624024477 0.316409823587168 no 1040 0.317638851800369 1458 24207091
SGTC_988 1497-1057 103 µM 0.473253420791802 0.316786335089389 no 1041 0.31801619464511 1582 3533044
SGTC_901 1112-0062 60.1 µM 0.47118284632967 0.317523599880355 no 1042 0.31875508364819 1530 1908457
SGTC_3331 9141060 1.957 µM 0.470198355264543 0.317874399683302 no 1043 0.319106654561948 1475 4906567 YPR165W RHO1
SGTC_59 0330-0160 1.33 µM 0.470152343838649 0.317890798754425 no 1044 0.31912308965373 1516 4293482
SGTC_1927 st060202 13.8 µM 0.469725196397707 0.318043056707456 no 1045 0.319275681927295 1564 688887
SGTC_1187 1391-0724 117 µM 0.469177226087077 0.318238427363492 no 1046 0.319471481264488 1549 6997986
SGTC_129 0088-0017 176.636 µM 0.468282217132909 0.318557638226285 no 1047 0.319791391802397 1587 182446
SGTC_2194 5927483 104.545 µM 0.468058101181744 0.318637591762225 no 1048 0.319871520444803 1543 760979
SGTC_54 0159-0055 9 µM 0.466209866509199 0.319297272576604 no 1049 0.320532643843661 1642 3319099
SGTC_2942 9052777 62.25 µM 0.46515684551401 0.319673378046561 no 1050 0.320909570034105 1591 6469503
SGTC_537 1334-0398 209 µM 0.462115722043108 0.320760610712405 no 1051 0.32199916809025 1636 5846986
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.460594369289439 0.321305088082763 no 1052 0.32254482605397 1653 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1034 k072-0165 12.7 µM 0.460474067388014 0.321348159373895 no 1053 0.322587990623619 1646 5835461
SGTC_956 1185-0240 191 µM 0.459163457655584 0.321817548194775 no 1054 0.323058394913264 1545 1416193
SGTC_1429 4049-0205 9.46 µM 0.458826927481919 0.321938120855957 no 1055 0.323179228101385 1552 22774478
SGTC_2516 gossypol 71.55 µM 0.456560136647347 0.322750758853474 no 1056 0.323993618612099 1661 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2883 9059145 45.46 µM 0.455905160550506 0.322985723838393 no 1057 0.324229089215517 1523 16476510
SGTC_52 0329-0193 875 nM 0.454552653803774 0.323471143288859 no 1058 0.324715551671246 1620 3739292
SGTC_2612 dictamnine 15.46 µM 0.450914256484193 0.324778467104221 no 1059 0.326025674015534 1547 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1125 tnp00248 1.32998 µM 0.449948361586676 0.325125889490982 no 1060 0.32637383754452 1735 24207736
SGTC_372 0155-0182 15.9 µM 0.449865701110664 0.325155628676676 no 1061 0.326403640121508 1611 771486
SGTC_2449 5812982 45.77 µM 0.449050148741056 0.325449103837366 no 1062 0.326697740422599 1544 776185
SGTC_2165 5727197 32.143 µM 0.448408532532059 0.32568006446091 no 1063 0.326929192481281 1631 1361712
SGTC_688 0527-0193 473 µM 0.447097336494545 0.326152259763749 no 1064 0.32740239103217 1589 4007154
SGTC_3 0833-0587 95.581 µM 0.443838243080895 0.327327149553675 no 1065 0.328579768404289 1540 5382644
SGTC_2223 6903751 107.57 µM 0.442280817352784 0.327889200649315 no 1066 0.329143005165545 1599 5598863
SGTC_1314 1222-0010 41.1 µM 0.441501749078817 0.328170500904959 no 1067 0.329424897774323 1584 3526027
SGTC_2521 angolensin 13.4 µM 0.440827960466308 0.328413866166961 no 1068 0.329668774937139 1589 821428 A flavenoid.
SGTC_2197 6588183 93.1375 µM 0.439948099985821 0.328731772015623 no 1069 0.329987348680718 1562 884136
SGTC_622 1348-1566 26.3 µM 0.439931928220339 0.328737616260729 no 1070 0.329993205195672 1646 7340407
SGTC_189 3970-0742 2.116 µM 0.439855632756237 0.328765188916815 no 1071 0.330020835735759 1621 2891807
SGTC_2047 4141938 200 µM 0.438102266262471 0.32939910009967 no 1072 0.330656075833436 1582 3807862
SGTC_1250 0485-0349 40.2 µM 0.437918776914265 0.329465467130818 no 1073 0.330722581787273 1551 6842794 YDL195W SEC31
SGTC_3125 9127534 49.47 µM 0.437742032820569 0.329529399522285 no 1074 0.330786647967947 1534 1639235
SGTC_164 4100-3994 89.624 µM 0.436045810775907 0.330143215079946 no 1075 0.331401746180759 1698 4615967
SGTC_2077 5212015 200 µM 0.434625262796981 0.330657623952903 no 1076 0.33191722739484 1484 780900
SGTC_799 1310-0557 151 µM 0.434057966584063 0.330863142748391 no 1077 0.33212317395645 1597 5354492
SGTC_1107 amlodipine 47 µM 0.433996042795085 0.330885579446944 no 1078 0.332145657331854 1521 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_510 ag-490 170 µM 0.431885817073579 0.33165053511038 no 1079 0.332912201706649 1678 5328779
SGTC_1558 st069300 45.6 µM 0.431766653243101 0.331693752920194 no 1080 0.332955509118321 1657 24208000
SGTC_932 2857-0803 154 µM 0.42835646861293 0.332931491040212 no 1081 0.33419580632331 1693 674898
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.428254565813423 0.332968505118293 no 1082 0.334232896719427 1545 16623 A steroid.
SGTC_1029 k015-0030 64.7 µM 0.427217084430426 0.333345441290813 no 1083 0.334610609387785 1632 2208316
SGTC_873 0591-4978 488 µM 0.426445823396388 0.333625763813542 no 1084 0.334891508558907 1734 3305145
SGTC_1739 st037196 92.5 µM 0.426110336563023 0.333747728858471 no 1085 0.335013724278053 1731 612214
SGTC_1330 1469-0054 61.8 µM 0.425976807471261 0.333796277773438 no 1086 0.335062372938486 1729 7102664
SGTC_1457 k015-0032 57.3 µM 0.424793391645128 0.334226669240934 no 1087 0.33549364774159 1574 4302660
SGTC_3191 9110352 49.47 µM 0.424273741333501 0.334415727581807 no 1088 0.335683093583832 1623 17122424
SGTC_725 1497-0963 19 µM 0.422428572104483 0.335087373175957 no 1089 0.336356113232408 1731 3549977
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.420912973115634 0.335639449336929 no 1090 0.336909315821422 1667 688662
SGTC_1116 jasmonic acid 1.58368 µM 0.420333563375115 0.335850600546292 no 1091 0.33712089713479 1652 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2893 9048488 25.97 µM 0.420182265103174 0.335905745906745 no 1092 0.337176154758031 1525 6467338
SGTC_930 2810-3379 265 µM 0.419941804423796 0.335993396548423 no 1093 0.337263983779718 1738 1015764
SGTC_2973 9094665 17.96 µM 0.419893335459062 0.336011065115439 no 1094 0.337281688296185 1707 25237061 YIL048W NEO1
SGTC_24 0417-1663 219 µM 0.419874415329242 0.336017962237129 no 1095 0.337288599450388 1577 4329390
SGTC_35 0133-0054 64.071 µM 0.419796000127245 0.336046548210496 no 1096 0.337317243578719 1510 99677
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.419668918025699 0.336092877536688 no 1097 0.337363667141277 1722 6728940
SGTC_1217 1183-1422 255 µM 0.419158878364022 0.336278843745481 no 1098 0.337550011422959 1676 2849664
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.418992186762484 0.3363396300716 no 1099 0.337610921262022 1595 521171
SGTC_2187 6125751 200 µM 0.418500367751095 0.336519003393543 no 1100 0.337790658864249 1621 874498
SGTC_2504 purpurogallin 52.29 µM 0.416698698387208 0.337176415146225 no 1101 0.338449403270655 1578 5281571 An antioxidant.
SGTC_2836 9010338 19.48 µM 0.416251874195865 0.337339534051505 no 1102 0.338612852241576 1466 2994051
SGTC_2019 4016004 108 µM 0.414604199468028 0.337941302925653 no 1103 0.339215836724585 1552 45595336
SGTC_1548 st061468 90.8 µM 0.414298591970684 0.338052963448633 no 1104 0.339327722453627 1659 390799
SGTC_2189 6047310 154.431 µM 0.414090508544149 0.338128999529417 no 1105 0.339403911826623 1585 711535
SGTC_1203 3992-3522 103 µM 0.413654962121254 0.338288174582023 no 1106 0.339563407616657 1830 5322312
SGTC_457 grayanotoxin iii 135 µM 0.413283664434699 0.338423892078841 no 1107 0.339699398405728 1582 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2070 5230947 200 µM 0.411951956324203 0.338910833326776 no 1108 0.340187318849537 1676 2835538
SGTC_2701 st077767 14.721 µM 0.410430244680382 0.339467579333473 no 1109 0.340745181835749 1602 5721188
SGTC_1024 4507-0395 26 µM 0.41030334707043 0.339514022994137 no 1110 0.340791718549919 1633 4201836
SGTC_1262 0737-0114 49.6 µM 0.409445699539769 0.339827980020654 no 1111 0.34110630411008 1685 765919
SGTC_1752 st044819 83.042 µM 0.408313598494933 0.340242575758881 no 1112 0.341521728513133 1556 441209 YML126C ERG13
SGTC_1826 st055655 41.6 µM 0.408167563250804 0.340296070567591 no 1113 0.341575330132026 1611 676168
SGTC_3083 9117465 49.47 µM 0.407526546284136 0.340530922301187 no 1114 0.341810650479856 1566 16420915
SGTC_27 0485-0001 32.618 µM 0.405909807321673 0.341123527408651 no 1115 0.342404435866151 1648 2054479
SGTC_3141 9094609 49.47 µM 0.405602529959442 0.341236202306798 no 1116 0.342517334822724 1562 25236309 YDL196W YDL196W
SGTC_805 3852-0218 479 µM 0.404687930507313 0.34157165862451 no 1117 0.342853457539259 1573 6615355
SGTC_1263 0774-1208 64.8 µM 0.404383678216981 0.341683279883774 no 1118 0.342965300316976 1756 906585
SGTC_1278 0874-0585 172 µM 0.404354360684433 0.341694036359736 no 1119 0.34297607813389 1649 766306
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.403945425626441 0.341844086262541 no 1120 0.343126425629753 1585 390807
SGTC_593 1203-0218 61.7 µM 0.403804723525385 0.341895719644017 no 1121 0.343178161369052 1720 3666956
SGTC_215 1287-0124 461.5 µM 0.403226308265545 0.342108011469006 no 1122 0.343390873791197 1726 5560863
SGTC_2137 5261020 140 µM 0.40268781326491 0.342305696504112 no 1123 0.343588950123473 1608 763655
SGTC_3027 9089541 49.47 µM 0.402438404790474 0.342397270632664 no 1124 0.343680705395696 1605 9943819
SGTC_1671 st016596 74.5 µM 0.401616112249336 0.342699253503971 no 1125 0.343983285093348 1610 2829167
SGTC_2272 7805186 180 µM 0.401550348464188 0.342723409273875 no 1126 0.344007488568649 1669 2956062 YPR165W RHO1
SGTC_1751 st044839 27.194 µM 0.401389627285753 0.342782446656859 no 1127 0.344066642523112 1648 5291326
SGTC_2313 7726885 200 µM 0.401246361227709 0.342835075522899 no 1128 0.344119375280627 1627 726423
SGTC_2519 cryptotanshinone 88.04 µM 0.401121985185578 0.342880767604464 no 1129 0.344165157540187 1696 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1035 k081-0041 55.2 µM 0.400637320458407 0.343058841020479 no 1130 0.344343582224983 1725 731709
SGTC_1942 st076330 65.2 µM 0.400459437632064 0.34312420670609 no 1131 0.344409076780563 1653 24208414
SGTC_200 k038-0079 37.545 µM 0.399867672355247 0.34334169341873 no 1132 0.344626991999582 1659 3436683
SGTC_3242 9133940 49.47 µM 0.39854423886682 0.34382827193294 no 1133 0.345114527677898 1664 17248444
SGTC_2381 9035592 200 µM 0.396637348442645 0.344529821348686 no 1134 0.345817453425324 1550 4749657
SGTC_983 1491-0821 12.2 µM 0.395384462446455 0.344991052485265 no 1135 0.346279587040267 1743 46495113
SGTC_1426 4048-4480 71.7 µM 0.394904790305807 0.345167697600676 no 1136 0.346456577291104 1705 14224343
SGTC_3015 9080845 49.47 µM 0.394670660141266 0.345253931145111 no 1137 0.346542979220825 1749 5296973
SGTC_1295 1013-0063 9.78 µM 0.392892937590698 0.345908954040688 no 1138 0.347199278997416 1757 6826038
SGTC_149 3970-0822 46.1 µM 0.392604222711191 0.346015378057632 no 1139 0.347305910113545 1648 3114250 YBL034C STU1
SGTC_2423 st077119 87.2 µM 0.392203116059987 0.346163251314516 no 1140 0.347454070961823 1604 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1899 st063254 59.6 µM 0.391505764233158 0.346420395096395 no 1141 0.347711714386733 1572 3093813
SGTC_1859 st055998 20 µM 0.390937477821128 0.346629999240354 no 1142 0.347921725366758 1777 676301
SGTC_132 0417-1715 25.805 µM 0.390020964820093 0.346968140595262 no 1143 0.348260522221326 1804 6769098
SGTC_1663 st014140 55.4 µM 0.389903066761263 0.34701164715196 no 1144 0.348304113043268 1715 4207120
SGTC_284 0988-0104 32.6 µM 0.388906577594468 0.347379450531617 no 1145 0.348672628126516 1708 4666532
SGTC_2341 7987486 176.74 µM 0.387391336646783 0.347939000202063 no 1146 0.349233258224273 1795 1258686
SGTC_2834 9001755 58.44 µM 0.386441766947097 0.348289827184679 no 1147 0.349584761194058 1643 2989575
SGTC_1364 1653-0028 37.6 µM 0.386217720525743 0.348372622074082 no 1148 0.349667715456263 1657 5718652
SGTC_1102 cgs 12066b 26.1 µM 0.386084713278922 0.348421777450268 no 1149 0.34971696542334 1672 6438352 A 5-HT1B full agonist.
SGTC_1351 1496-0003 46.5 µM 0.385287793911381 0.348716347564881 no 1150 0.350012101936234 1720 3891978
SGTC_333 3486-0131 40.1 µM 0.384402981134137 0.349043513121912 no 1151 0.350339895661559 1767 6744690
SGTC_2084 5306078 60.6385 µM 0.383941358429093 0.34921424583484 no 1152 0.350510955808799 1696 679340
SGTC_2369 9071472 200 µM 0.38325420285067 0.349468449163295 no 1153 0.3507656461728 1702 17296037
SGTC_2868 9035608 32.47 µM 0.382006712784312 0.349930112687407 no 1154 0.351228192742245 1597 6462614
SGTC_1346 1488-2224 62.4 µM 0.38191288933641 0.349964843279218 no 1155 0.351262989688237 1753 3722427
SGTC_1435 4092-0789 56.7 µM 0.381757744450849 0.350022275959201 no 1156 0.351320532072115 1751 2248285
SGTC_1569 carminic acid 40.6 µM 0.381037189796032 0.350289061157537 no 1157 0.351587826480405 1775 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3145 9085516 49.47 µM 0.376380682054919 0.352014908581114 no 1158 0.353316952723701 1607 25236195
SGTC_2014 4013930 200 µM 0.376361083423179 0.352022178923309 no 1159 0.353324236822319 1705 64556
SGTC_2863 9028737 58.44 µM 0.376212800070849 0.352077188123986 no 1160 0.353379350092256 1770 6460917
SGTC_2056 5235370 200 µM 0.375143177192719 0.352474081553549 no 1161 0.353776993588292 1624 5511916
SGTC_3241 9133421 49.47 µM 0.374976809956566 0.352535828100352 no 1162 0.353838856700549 1685 17018221
SGTC_2023 5144124 124 µM 0.373797538293615 0.352973621461666 no 1163 0.35427747555857 1634 2830192
SGTC_2740 felodipine 17.08 µM 0.373475278725204 0.353093291153205 no 1164 0.354397370601052 1776 3333 L-type calcium channel blocker
SGTC_110 0850-0284 111.64 µM 0.372464088603181 0.353468886497571 no 1165 0.35477367240535 1627 3906265
SGTC_2175 5807670 165.306 µM 0.369815494521238 0.354453353103111 no 1166 0.355759984751382 1746 241186
SGTC_1864 st057645 30.4 µM 0.369775964377785 0.354468053608237 no 1167 0.355774712752683 1729 688666
SGTC_2560 caryophyllene 100 µM 0.368762123792478 0.354845155580876 no 1168 0.35615251940934 1668 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_3210 9128157 49.47 µM 0.368432867249824 0.354967654461772 no 1169 0.35627524692988 1602 17590849
SGTC_1077 5-fluorocytosine 377 nM 0.368101479791441 0.355090961283373 no 1170 0.35639878376445 1692 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_168 3970-0862 530.542 µM 0.367486267512245 0.355319917454533 no 1171 0.356628166665471 1697 3135186
SGTC_851 0394-0702 453 µM 0.367050054910998 0.355482289116156 no 1172 0.356790840674047 1792 762646
SGTC_601 0986-0029 62.9 µM 0.36559071894781 0.35602568909745 no 1173 0.35733525079876 1682 24747981
SGTC_1702 st027038 51 µM 0.364478328873313 0.356440096503024 no 1174 0.357750426795973 1696 5521182
SGTC_642 0335-0876 158 µM 0.363894636866502 0.356657611730393 no 1175 0.357968344833064 1690 6812350
SGTC_2915 7971052 15.16 µM 0.363462313106324 0.356818749017796 no 1176 0.35812978025457 1667 5741558
SGTC_1147 3809-1045 12.3 µM 0.36309230322723 0.356956680742575 no 1177 0.35826796699557 1654 325925
SGTC_2837 9008476 45.46 µM 0.362427815092005 0.357204434565143 no 1178 0.358516178455375 1728 2992805
SGTC_3071 9117417 49.47 µM 0.360833141060044 0.357799252872943 no 1179 0.359112093252507 1801 45595590 YGL055W OLE1
SGTC_1178 0988-0033 191 µM 0.360368129423887 0.357972768763039 no 1180 0.35928592840995 1725 5392207
SGTC_1491 4138-0063 26.5 µM 0.359813047696287 0.358179932108161 no 1181 0.359493472583061 1785 23883227
SGTC_1118 chelidonine 707.474 nM 0.359556993641703 0.358275508716938 no 1182 0.359589224761611 1822 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2764 methyldopa 94.69 µM 0.357521993542215 0.359035423047308 no 1183 0.360350532131523 1798 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1552 6-methylflavone 10.6 µM 0.356601300384204 0.359379413933762 no 1184 0.360695151919366 1804 689013
SGTC_98 0074-0023 107.663 µM 0.355102716269773 0.359939561076615 no 1185 0.361256320901874 1639 3563821
SGTC_2606 farnesol 9.78 µM 0.354786739219905 0.360057706775833 no 1186 0.361374681770603 1785 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_497 capsazepine 133 µM 0.354220171851321 0.360269583157028 no 1187 0.361586943715102 1605 2733484 A calcium channel blocker.
SGTC_1956 st077085 54 µM 0.353241178338178 0.360635793623727 no 1188 0.361953819655231 1672 24208685
SGTC_2174 5790901 200 µM 0.353210667525161 0.360647208808551 no 1189 0.361965255564451 1688 786020
SGTC_2168 5727979 200 µM 0.352743637820877 0.3608219567928 no 1190 0.362140320661158 1651 695210
SGTC_3154 9100113 49.47 µM 0.352053829297994 0.361080114831621 no 1191 0.362398946679022 1653 25237525
SGTC_2131 toluylene red 5.2905 µM 0.351933599478683 0.361125116833459 no 1192 0.362444030198183 1630 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_997 3996-0078 137 µM 0.349957432787774 0.361865070729745 no 1193 0.363185321878846 1696 735687
SGTC_1260 0700-1617 7.75 µM 0.349375052288818 0.362083235406713 no 1194 0.363403880053836 1726 2853078
SGTC_1221 2958-7315 257 µM 0.349163726142881 0.362162411059396 no 1195 0.363483198409059 1726 4562705
SGTC_484 loperamide 105 µM 0.348999593686246 0.362223909149524 no 1196 0.363544807302085 1712 3955 An opioid-receptor agonist.
SGTC_1454 4239-0054 42.6 µM 0.348377077591103 0.362457189361472 no 1197 0.363778507516392 1810 1340767
SGTC_2009 4012297 12.05 µM 0.346446477309221 0.363180982448793 no 1198 0.364503600658956 1675 45595307
SGTC_750 4073-0104 132 µM 0.345453000519887 0.363553633260929 no 1199 0.364876919000733 1673 22330957
SGTC_2349 9023730 187.07 µM 0.345227858610511 0.363638101424311 no 1200 0.364961538300525 1805 4126287
SGTC_1495 4469-0029 237 µM 0.344819950414801 0.363791156255802 no 1201 0.365114866827102 1676 793680
SGTC_1394 3474-0001 65.7 µM 0.343987199880201 0.364103687390094 no 1202 0.36542795618838 1683 5017666 YIL048W NEO1
SGTC_1611 st001856 99.4 µM 0.343908859395499 0.364133093216124 no 1203 0.365457414492929 1673 647478
SGTC_1920 st075728 45.7 µM 0.343275007267436 0.364371044884775 no 1204 0.365695790534755 1868 3400306
SGTC_778 3456-2434 196 µM 0.342908517568049 0.364508651047146 no 1205 0.365833641880349 1862 5539063
SGTC_3219 9131112 49.47 µM 0.341921007657732 0.364879519005906 no 1206 0.366205169804984 1730 17612988 YMR079W SEC14
SGTC_2086 5274770 176.623 µM 0.340983836459743 0.365231598786504 no 1207 0.366557874987293 1707 689278
SGTC_942 3253-1115 227 µM 0.339827368436248 0.365666221364848 no 1208 0.366993268070388 1813 46497897
SGTC_2859 9028643 45.46 µM 0.338639726282542 0.366112739320616 no 1209 0.367440575872106 1809 17151580
SGTC_653 0203-0016 55.2 µM 0.337908143180191 0.366387883018717 no 1210 0.367716205390407 1762 295302
SGTC_2348 9022543 33.42 µM 0.336925828847994 0.366757433144418 no 1211 0.36808640697147 1750 3162678 YDL140C RPO21
SGTC_1679 SEC14.276 6.7 µM 0.335767686879025 0.367193288913582 no 1212 0.368523029523049 1870 1005053 YMR079W SEC14
SGTC_2474 5321570 43.32 µM 0.335687500358513 0.367223472694956 no 1213 0.368553266342997 1817 2841384
SGTC_445 e6 berbamine 66 µM 0.335324808965181 0.367360007106461 no 1214 0.368690040570034 1710 6610268 A calcium/calmodulin antagonist.
SGTC_1948 st076329 66.6 µM 0.334407454941526 0.367705417918074 no 1215 0.36903605733844 1704 24208413
SGTC_253 dyclonine 31.25 µM 0.334095821347546 0.367822781515298 no 1216 0.36915362658634 1790 3180 An oral anasthetic.
SGTC_894 0960-0238 55.9 µM 0.332065551174906 0.368587698481475 no 1217 0.369919880883651 1782 6741907 YDL195W SEC31
SGTC_1641 st009299 47.1 µM 0.331511613196324 0.368796488668899 no 1218 0.370129035203554 1796 4046054
SGTC_1103 duloxetine 36.1 µM 0.33113141098703 0.368939816824911 no 1219 0.370272613101416 1825 60835 A selective serotonin reuptake inhibitor.
SGTC_1387 3342-1166 1.8 µM 0.330426599691034 0.369205563912126 no 1220 0.370538822756384 1755 3418228
SGTC_3032 9089427 49.47 µM 0.327936061934959 0.370145114082696 no 1221 0.371480003309188 1718 17173707
SGTC_2711 st079103 59.1 µM 0.327031236371252 0.370486649965243 no 1222 0.371822129909168 1830 54693780
SGTC_265 mycophenolic acid 32.932 µM 0.326914262938485 0.370530810271097 no 1223 0.371866366518666 1841 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1726 st035556 14.5795 µM 0.325638427729682 0.371012579649809 no 1224 0.372348967211244 1841 5919439
SGTC_1705 st027868 56.3335 µM 0.324805431651873 0.371327237291822 no 1225 0.372664166695838 1831 292948
SGTC_3285 9112818 20.8695 µM 0.324477440415156 0.371451156987562 no 1226 0.372788299540801 1748 17017947 YPR165W RHO1
SGTC_2376 9072922 81.32 µM 0.324421446599114 0.371472313569594 no 1227 0.372809492499778 1767 17087968
SGTC_1934 st074720 32.6 µM 0.322685068828567 0.372128575205483 no 1228 0.373466880547771 1657 17250992
SGTC_1047 2043-3044 82 µM 0.32209452010786 0.372351857076067 no 1229 0.37369054478889 1674 669592
SGTC_25 0118-0223 35.662 µM 0.321911173979324 0.372421187552731 no 1230 0.373759993904014 1809 5333628
SGTC_1254 0550-0035 264 µM 0.321295179115322 0.372654150024963 no 1231 0.373993354709414 1832 15121435
SGTC_1892 st058411 7.36 µM 0.321144011605945 0.372711327034922 no 1232 0.37405062941038 1847 3934738
SGTC_2128 5255449 168.493 µM 0.320995411310108 0.372767535765793 no 1233 0.374106934149583 1719 736008
SGTC_2366 9070441 60.58 µM 0.320521104972481 0.372946962392026 no 1234 0.374286667060944 1686 6837235
SGTC_1131 3454-3128 32.3 µM 0.319921995985384 0.37317364034405 no 1235 0.374513731548356 1835 710982
SGTC_2752 diclazuril 33.15 µM 0.319561761700423 0.373309959174262 no 1236 0.374650282612196 1857 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1031 k035-0009 16 µM 0.319068767223088 0.37349654243636 no 1237 0.37483718347119 1879 5180959
SGTC_3321 9137793 26.8275 µM 0.319064276406848 0.373498242208708 no 1238 0.374838886135423 1748 4904192
SGTC_3225 9130819 49.47 µM 0.318310238586179 0.373783680130997 no 1239 0.375124809319687 1811 4547121
SGTC_3354 9151612 71.43 µM 0.317925860528467 0.373929211520791 no 1240 0.375270587843254 1858 27261949
SGTC_732 3970-1727 52.7 µM 0.317468011182784 0.374102583713116 no 1241 0.375444254201624 1883 1275699
SGTC_1451 4152-0210 104 µM 0.315119548621686 0.374992267376607 no 1242 0.376335443219366 1870 659563
SGTC_2690 usnic acid 100 µM 0.31304763284056 0.375777737841549 no 1243 0.377122236865551 1892 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3312 9133330 71.43 µM 0.312330641450231 0.376049671889333 no 1244 0.377394627728746 1847 17617324
SGTC_330 1488-0319 80.1 µM 0.311591290857946 0.376330150601541 no 1245 0.377675576922247 1786 6846614
SGTC_230 MPP+ 141.667 µM 0.311509881964832 0.376361037727609 no 1246 0.377706515816363 1702 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2955 9076254 12.21 µM 0.311244214522755 0.376461839393992 no 1247 0.377807486371386 1903 16459619
SGTC_1176 0848-0131 83.3 µM 0.310606089423942 0.376703996336307 no 1248 0.378050048667886 1916 6769040
SGTC_1156 4092-0367 4.88 µM 0.310177005909658 0.376866853063315 no 1249 0.378213177713 1776 1357585
SGTC_1708 st033234 31.827 µM 0.310016052845949 0.37692794773074 no 1250 0.37827437447807 1845 674664
SGTC_1559 coumarin 343 70.1 µM 0.309866086516786 0.376984874819756 no 1251 0.37833139667029 1828 108770 A hepatotoxic, DNA x-linker.
SGTC_745 0469-0705 296 µM 0.309516156501604 0.377117718349265 no 1252 0.378464462018128 1886 3486736
SGTC_169 k015-0017 16.025 µM 0.308998998575202 0.377314073047304 no 1253 0.378661144296547 1847 1840002
SGTC_3270 9137563 49.47 µM 0.307778048261612 0.377777769646497 no 1254 0.379125613125797 1837 17015724
SGTC_2339 9000433 200 µM 0.307663527658571 0.377821271712309 no 1255 0.379169187540991 1696 2988954
SGTC_3324 9138759 60.749 µM 0.304236555811694 0.379123763984522 no 1256 0.380473838234334 1794 45595710
SGTC_336 4111-0029 111 µM 0.303155556064428 0.379534906202031 no 1257 0.380885658645562 1749 3131175
SGTC_1849 st056239 19.2 µM 0.300706694296183 0.380466797735908 no 1258 0.381819081808363 1674 5393181
SGTC_2491 paeonol 100 µM 0.299773539877884 0.380822083896835 no 1259 0.382174949875513 1757 11092 Increases levels of cortical cytochrome oxidase.
SGTC_440 fluspirilene 35.1 µM 0.299195946798774 0.381042045179412 no 1260 0.382395270860075 1854 3396 An atypical antipsychotic.
SGTC_248 streptozotocin 5.23457 mM 0.299110736635425 0.381074498506862 no 1261 0.382427777221958 1887 5300 DNA alkylating agent.
SGTC_2463 5473429 200 µM 0.298524241640064 0.381297894943485 no 1262 0.382651538473662 1763 5399405
SGTC_868 0527-0199 213 µM 0.296919147554486 0.381909478700628 no 1263 0.383264118702311 1785 2849450
SGTC_937 3122-0005 46.7 µM 0.29673471582139 0.38197977103542 no 1264 0.383334525353548 1912 759535
SGTC_2645 abamectin 100 µM 0.296122767149657 0.382213030456531 no 1265 0.383568163809959 1872 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2751 anetholtrithion 17.25 µM 0.295673968740902 0.382384128287925 no 1266 0.383739539359701 1893 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1017 4239-0030 168 µM 0.29566553107598 0.382387345244348 no 1267 0.383742761535253 1708 1149593
SGTC_2447 5741742 33.78 µM 0.295488243348632 0.382454940098379 no 1268 0.383810466032615 1838 1776504
SGTC_2707 st078556 66.6 µM 0.295055822468484 0.382619825109001 no 1269 0.383975618327341 1925 17250899
SGTC_2393 9031399 185.94 µM 0.294227853010176 0.382935594828817 no 1270 0.384291899246084 1868 1526623 YDL150W RPC53
SGTC_1226 3909-7979 35.4 µM 0.294175664160562 0.382955501141319 no 1271 0.384311837755185 1894 6615510
SGTC_2466 5983409 37.09 µM 0.293553481353648 0.383192843167937 no 1272 0.384549563389061 1772 2879657
SGTC_2412 st077135 33.4 µM 0.2928726220826 0.38345261856054 no 1273 0.384809758073376 1860 13258915
SGTC_1521 st012942 49.4 µM 0.291038764992127 0.384152569682227 no 1274 0.385510835969703 1951 24207259
SGTC_1486 3970-0793 4.53 µM 0.288816291285695 0.385001355436535 no 1275 0.38636098225004 1915 2844330
SGTC_2625 euphol 100 µM 0.287008844362665 0.385692044893851 no 1276 0.387052774094355 1938 6708538 A triterpene alcohol.
SGTC_2437 5741531 144.16 µM 0.286819583728757 0.385764389091623 no 1277 0.387125233513034 1921 2262990
SGTC_2576 guaiol 23.12 µM 0.286252190406982 0.38598129695562 no 1278 0.387342486562264 1956 227829
SGTC_569 4130-2812 160 µM 0.286159606551038 0.386016694071209 no 1279 0.387377939968816 1929 743552
SGTC_682 0kpi-0099 17 µM 0.286005872511807 0.386075472521828 no 1280 0.387436811868425 1766 1714895 YML126C ERG13
SGTC_1724 st037281 8.293 µM 0.284557025115969 0.386629551027977 no 1281 0.387991769767764 1758 574124 YDL195W SEC31
SGTC_3268 9137683 49.47 µM 0.284518809123778 0.386644168993385 no 1282 0.388006410896797 1796 1953228
SGTC_2308 7584454 197.62 µM 0.282218066489141 0.387524519638541 no 1283 0.388888153043512 1895 893577
SGTC_2654 protoveratrine a 100 µM 0.28136588527041 0.387850743312638 no 1284 0.389214890604328 1842 5702278 A heart drug and vasodilator.
SGTC_272 doxorubicin 8.13 µM 0.280248148101897 0.388278744509443 no 1285 0.389643564578841 1835 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_163 TUB2.036 7.546 µM 0.280057964918173 0.388351582515585 no 1286 0.389716516917324 1891 15992207 YJR013W GPI14
SGTC_3309 9129340 25.759 µM 0.279991771969121 0.38837693458695 no 1287 0.389741908772256 1850 17158987
SGTC_1604 st002052 72.4 µM 0.279772222491072 0.388461026011199 no 1288 0.389826132115491 1828 6254834 YHR062C RPP1
SGTC_3234 9132280 49.47 µM 0.279749388028026 0.388469772324103 no 1289 0.389834892145622 1821 17612295
SGTC_1683 st010134 710 nM 0.277887642062523 0.389183069092279 no 1290 0.390549305318862 1736 3818134
SGTC_1061 3448-9325 110 µM 0.276890143892026 0.389565397672711 no 1291 0.390932230432467 1935 723482
SGTC_2291 7917025 104.35 µM 0.275982607093057 0.389913338075949 no 1292 0.391280712584565 1760 2964612
SGTC_2053 5265679 138 µM 0.275753923366939 0.390001027025074 no 1293 0.391368537896963 1779 764595
SGTC_2496 diffractaic acid 79.83 µM 0.275217160899478 0.390206870985809 no 1294 0.391574701692727 1942 94870 An apoptosis inducer which activates caspases.
SGTC_3030 9087619 49.47 µM 0.274938775073884 0.390313641772097 no 1295 0.391681638228292 1785 25236973
SGTC_1838 st055369 84.5 µM 0.27322949293326 0.390969392850618 no 1296 0.392338405060967 1833 676036
SGTC_63 0099-0242 26.702 µM 0.272887741939062 0.39110053987816 no 1297 0.392469754775493 1959 3898502 YLR359W ADE13
SGTC_1274 0865-0114 173 µM 0.271990380176801 0.391444961588337 no 1298 0.392814708059057 1843 870624
SGTC_1170 0310-0127 64.8 µM 0.269055225951285 0.392572113686543 no 1299 0.393943592403863 1861 774975
SGTC_3347 9188721 44.724 µM 0.268927890980959 0.392621033083342 no 1300 0.393992586725809 1877 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2074 5212007 75.395 µM 0.268208637116808 0.392897387007383 no 1301 0.394269363514808 1971 758611
SGTC_953 1188-0045 9.7 µM 0.268082075955572 0.392946020314852 no 1302 0.394318071168582 1867 6144426
SGTC_2689 tacrolimus 100 µM 0.267623212268047 0.39312236060285 no 1303 0.394494680853571 1814 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_590 k048-0076 22.4 µM 0.26636380674823 0.393606459929237 no 1304 0.394979518321597 1944 6832814
SGTC_1524 corynanthine 62.1 µM 0.265196117045207 0.394055451859803 no 1305 0.395429192999261 1865 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2682 pyrogallin 40.03 µM 0.265170036055452 0.394065481950992 no 1306 0.395439238321947 1889 822798 An ATP competetive kinase inhibitor.
SGTC_2443 5493264 126.67 µM 0.264409212036498 0.394358106583353 no 1307 0.395732306934241 1927 5340055
SGTC_3146 9095609 49.47 µM 0.263536725353266 0.394693751790706 no 1308 0.396068460455585 1887 17173999
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.263329350474061 0.394773540316031 no 1309 0.396148369668238 1931 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1073 triclabendazole 3.09 µM 0.261855673654172 0.395340671811157 no 1310 0.396716357368349 1845 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_833 3852-0053 558 µM 0.260851223098138 0.395727352879484 no 1311 0.397103620572414 1891 3123681
SGTC_697 0508-1955 564 µM 0.260395802880675 0.395902708821142 no 1312 0.397279240068147 1978 6243113
SGTC_2788 5282734 71.43 µM 0.260176409358719 0.395987192078268 no 1313 0.397363850203074 1945 743706
SGTC_3121 9125696 49.47 µM 0.257674803776379 0.39695084578103 no 1314 0.398328946635486 2005 1235365
SGTC_89 0302-0250 142.109 µM 0.25692413767865 0.397240136005533 no 1315 0.398618668356256 1912 4203518 YLR208W SEC13
SGTC_217 ketoconazole 989 nM 0.25690373317713 0.397248000242253 no 1316 0.398626544312624 1883 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_250 brefeldin a 552.239 µM 0.255973308889923 0.397606645683876 no 1317 0.398985723639121 1862 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_822 1487-0950 154 µM 0.25571709660052 0.397705421614904 no 1318 0.399084646408328 1977 1958375
SGTC_929 2805-0021 398 µM 0.25506890779328 0.397955343086779 no 1319 0.399334939020161 1853 3098024
SGTC_1953 st076800 12.1 µM 0.253724004022705 0.398474029689896 no 1320 0.39985439411175 1764 297591
SGTC_2518 prenyletin 46.28 µM 0.253689575210045 0.398487310146775 no 1321 0.399867694213563 1972 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2324 6149169 200 µM 0.250528011323332 0.399707340576485 no 1322 0.401089522657115 1948 2888231
SGTC_474 dl-dihydrosphingosine 5 µM 0.250379271320524 0.399764762766058 no 1323 0.401147029145726 1942 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1932 st074806 40.9 µM 0.249042576244859 0.400280901028192 no 1324 0.401663923809837 1925 17251235
SGTC_299 1273-0059 1.44 µM 0.248987833859439 0.400302042432768 no 1325 0.401685096146611 1958 2848077
SGTC_2918 7977171 22.06 µM 0.247901118063622 0.400721790380846 no 1326 0.402105457407842 1855 2236483
SGTC_84 0443-0269 128.823 µM 0.2455239458082 0.401640380957846 no 1327 0.403025384704245 1961 6150058
SGTC_1658 st012944 20 µM 0.243279233229437 0.402508285544152 no 1328 0.403894545345353 1948 24207260
SGTC_2611 pyromycin 23.93 µM 0.243030017186319 0.402604673152689 no 1329 0.403991072034522 1808 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1180 1193-0155 285 µM 0.241481534599506 0.403203701786683 no 1330 0.404590963169126 1864 2921347
SGTC_1783 st039459 87.517 µM 0.240865422843756 0.403442107148803 no 1331 0.404829710905278 1998 729761
SGTC_2939 9044578 71.43 µM 0.238947931440649 0.404184312574632 no 1332 0.405572978969083 1847 2653634
SGTC_306 1672-3436 11.6 µM 0.238833459641819 0.404228632234696 no 1333 0.405617361927587 1935 6797378
SGTC_2261 9010538 184.68 µM 0.238565042703864 0.404332559134121 no 1334 0.405721437189323 1812 6457250
SGTC_1682 st012968 530 nM 0.237679001590472 0.404675668478194 no 1335 0.406065035660312 1800 24207270
SGTC_247 mechlorethamine 29.705 µM 0.237070360203233 0.404911400425255 no 1336 0.406301103051897 1915 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_227 fluconazole 33.516 µM 0.237025872192629 0.404928632361772 no 1337 0.40631835948988 1845 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_359 0081-0058 15.9 µM 0.236687059455686 0.405059873756195 no 1338 0.406449787404817 1986 3494159
SGTC_1054 3429-0080 167 µM 0.234811878185047 0.405786430553714 no 1339 0.40717737400776 1960 1162877
SGTC_2817 7995342 71.43 µM 0.234272929071293 0.405995311683705 no 1340 0.407386550330056 1825 18879975
SGTC_626 0214-0009 33 µM 0.231731813497333 0.406980534409679 no 1341 0.408373160133925 1966 3437874
SGTC_594 1487-1584 10.8 µM 0.230616231501658 0.407413246090663 no 1342 0.408806478285916 1820 5013332
SGTC_1681 tripelennamine 100 µM 0.230310165247636 0.407531982773648 no 1343 0.408925381093348 1965 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_352 k048-0007 5.11 µM 0.229806590002127 0.407727360443021 no 1344 0.409121031841803 1980 6811911
SGTC_134 0269-0018 6.916 µM 0.229672572613586 0.407779360523408 no 1345 0.409173104545247 1857 4378915
SGTC_1164 k060-0068 93.7 µM 0.229285170247103 0.407929685629805 no 1346 0.409323639459284 1949 5963676
SGTC_1286 0929-0070 131 µM 0.228673254813762 0.408167156938864 no 1347 0.409561441794495 1964 1420408
SGTC_181 1447-1644 8.07 µM 0.226460643780132 0.409026104924569 no 1348 0.410421582920235 2014 534600
SGTC_8 0354-0001 70 µM 0.226400137743988 0.40904959986415 no 1349 0.41044511040346 1908 4993152
SGTC_2575 plumbagin 510 nM 0.225621960191185 0.409351801038638 no 1350 0.410747729727956 1822 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1339 1486-1321 22.7 µM 0.224174617922204 0.409914011983834 no 1351 0.411310716425098 1893 3469382
SGTC_1273 0849-0096 14.1 µM 0.223955491644353 0.409999146374768 no 1352 0.41139596804053 1877 5286025
SGTC_3128 9127691 49.47 µM 0.223493829278865 0.410178524157714 no 1353 0.411575592603214 1925 41316314
SGTC_256 clotrimazole 625 nM 0.222851083314841 0.410428292822528 no 1354 0.41182570440992 1953 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_580 1123-0028 41 µM 0.222665079110337 0.410500580140247 no 1355 0.411898090934854 1985 1677248 YPR107C YTH1
SGTC_1691 st019933 84.6 µM 0.218654666085808 0.412059893370605 no 1356 0.413459532811448 2057 6176082
SGTC_64 000l-0018 272.079 µM 0.216846348435215 0.412763452424165 no 1357 0.414164045197498 1854 6811119
SGTC_1836 st055642 81 µM 0.21548757176964 0.413292293931543 no 1358 0.414693600381909 1836 8571
SGTC_1104 tacrolimus 29.8 µM 0.21527828888024 0.41337376170775 no 1359 0.414775177877636 1927 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_850 0388-0143 75.9 µM 0.214823487139553 0.413550815727199 no 1360 0.414952470146198 1909 67273
SGTC_1436 4092-1007 8.32 µM 0.214403041364921 0.413714510629745 no 1361 0.41511638507227 1941 2881121
SGTC_1105 epirubicin 18.1 µM 0.213685446956206 0.413993930976762 no 1362 0.415396180437122 1880 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3323 9138564 53.9225 µM 0.213532357666181 0.414053547258184 no 1363 0.41545587664092 2043 43912313 YNL103W MET4
SGTC_1608 st001473 40.5 µM 0.213378545743522 0.414113446943004 no 1364 0.415515856596067 1853 7292267
SGTC_2982 9019404 25.97 µM 0.212984453649539 0.414266929155014 no 1365 0.415669544340091 1721 22333232
SGTC_2582 agaric acid 100 µM 0.212402938118568 0.414493428781216 no 1366 0.415896346893289 1888 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2054 5233173 129 µM 0.212286595640297 0.414538747457824 no 1367 0.415941726125335 1948 6889
SGTC_414 piperonyl butoxide 100 µM 0.210966051422544 0.415053216272206 no 1368 0.416456881093147 1888 5794 A potent inhibitor of cytochrome P450.
SGTC_4 0960-0234 25.671 µM 0.210892733347488 0.415081784427052 no 1369 0.416485487280371 1915 6821112
SGTC_2343 7990716 14.84 µM 0.210732972317092 0.415144036359611 no 1370 0.416547822062776 1975 6456862
SGTC_1793 st048256 72.231 µM 0.208634856073352 0.415961778247623 no 1371 0.417366649050924 2000 672022
SGTC_1075 aripiprazole 15.2 µM 0.208471208987201 0.416025575131367 no 1372 0.417430530338382 1905 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1550 gossypolone 36.6 µM 0.206392497154827 0.416836141114491 no 1373 0.418242165537585 2046 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1010 4112-3296 15.2 µM 0.206104860504546 0.416948329127164 no 1374 0.418354501074436 2094 704384
SGTC_1175 0741-0056 27.6 µM 0.205188730299133 0.417305695896375 no 1375 0.418712337020908 2020 765927
SGTC_114 0364-0001 490.298 µM 0.204478223390658 0.41758289958185 no 1376 0.418989903853099 1893 4003655
SGTC_2204 7233102 200 µM 0.204441657247999 0.417597166941764 no 1377 0.419004189885167 2003 2172480
SGTC_1781 st038725 66.3 µM 0.203987331574088 0.417774444555292 no 1378 0.419181699355766 1874 4270275 YIL048W NEO1
SGTC_490 phenamil 164 µM 0.202985063064348 0.418165588191166 no 1379 0.419573353564518 2051 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_608 k048-0125 159 µM 0.20278063393372 0.418245378314356 no 1380 0.419653247672363 2045 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_918 glabranin 770.725 nM 0.202759625525515 0.418253578234099 no 1381 0.419661458275237 1967 124049 Also referred to as licorice root.
SGTC_2368 9071271 200 µM 0.202439827365724 0.418378404986215 no 1382 0.419786447581565 1885 27209959
SGTC_974 1326-0144 138 µM 0.202053426663989 0.418529239661331 no 1383 0.419937478493426 1897 5411856
SGTC_2489 cantharidin 73.42 µM 0.201639042177543 0.418691011347965 no 1384 0.420099460419704 1962 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_83 0170-0301 39.027 µM 0.201256151501341 0.41884050038043 no 1385 0.420249143521037 2067 3089716
SGTC_2192 5915882 198.485 µM 0.201145521568704 0.418883694948888 no 1386 0.420292394128088 1982 2876149
SGTC_2100 5377183 190 µM 0.200623238564256 0.419087629349423 no 1387 0.420496592878013 2005 2844202
SGTC_2630 antimycin a 100 µM 0.200524038543452 0.419126366165773 no 1388 0.420535379864795 1949 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_565 1418-0001 44.5 µM 0.200400472868944 0.419174618671834 no 1389 0.420583694846864 2032 2862145
SGTC_1219 1469-0211 33.1 µM 0.199947744531691 0.419351419872468 no 1390 0.42076072478677 2045 6822282
SGTC_856 0433-0016 11.3 µM 0.199511223305975 0.419521907230863 no 1391 0.420931432450888 1948 3911780
SGTC_1504 k297-0033 30 µM 0.199365634581304 0.419578771600564 no 1392 0.420988370243535 1871 4388117
SGTC_1800 st050079 29.0735 µM 0.198108956011403 0.420069677617434 no 1393 0.421479908912115 1972 3645560
SGTC_1652 st011932 78 µM 0.197883534696607 0.420157748858449 no 1394 0.421568093426137 2040 1551076
SGTC_1362 1611-0397 101 µM 0.197037418857114 0.420488358695561 no 1395 0.421899127858268 1940 27816
SGTC_1561 5-methoxyflavone 52.9 µM 0.196857567996303 0.420558640546672 no 1396 0.421969499844724 2057 94525
SGTC_2394 5221648 200 µM 0.195650136977574 0.421030544105007 no 1397 0.42244200746654 2024 788586
SGTC_3044 9093193 49.47 µM 0.194828718592582 0.421351646196099 no 1398 0.422763519446745 1892 25236277
SGTC_968 1309-0633 340 µM 0.19185008368855 0.422516466826857 no 1399 0.423929819229666 2081 3761976
SGTC_2838 9002687 71.43 µM 0.191777466936694 0.42254487273423 no 1400 0.42395826105661 1869 6457060
SGTC_3123 9126162 49.47 µM 0.190649658386331 0.422986095631731 no 1401 0.424400040957055 1938 25239884
SGTC_678 1218-2179 85.9 µM 0.18890563484034 0.423668585095245 no 1402 0.425083388564758 2053 6820081 YOR116C RPO31
SGTC_2841 9004761 38.96 µM 0.187721937957155 0.424131932304351 no 1403 0.425547315995743 1832 2991039
SGTC_210 3551-0445 56.827 µM 0.187543233352695 0.424201893699377 no 1404 0.425617364832039 2033 2865180 YOR207C RET1
SGTC_2904 7225135 42.03 µM 0.186263871996131 0.424702822867187 no 1405 0.426118918804765 2092 4446116
SGTC_1749 st037932 54.2 µM 0.186041616661314 0.42478985853744 no 1406 0.426206062804565 1959 594497
SGTC_2216 7189485 200 µM 0.18418669697071 0.425516391709892 no 1407 0.426933497612138 2069 731273
SGTC_2717 st081029 62.2815 µM 0.183558502330294 0.42576249985505 no 1408 0.427179910106958 2098 5292846
SGTC_2251 lansoprazole 556 µM 0.18331025167979 0.425859765121702 no 1409 0.427277295506976 1887 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2444 5485484 36.41 µM 0.18288494292401 0.42602641270735 no 1410 0.42744414872364 2033 6790631
SGTC_1334 1486-0610 236 µM 0.181786469748739 0.42645688555183 no 1411 0.427875151587772 2029 3742339
SGTC_2652 actinonin 100 µM 0.181528674046998 0.426557923991266 no 1412 0.427976314189956 2041 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1505 k297-0037 20.6 µM 0.179089845125709 0.427514017182546 no 1413 0.428933577758979 1942 4089396
SGTC_1296 1068-0102 11.9 µM 0.177318698811426 0.42820862627435 no 1414 0.429629031995703 2080 767053
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.177290819699872 0.428219561703269 no 1415 0.429639980695361 2004 364106
SGTC_2853 9015042 58.44 µM 0.177129281013599 0.428282925453589 no 1416 0.429703421319925 2006 6457456
SGTC_534 k292-0788 63.4 µM 0.175626439703562 0.428872505232259 no 1417 0.430293714661728 2139 4146317
SGTC_1319 1306-0155 43.7 µM 0.174666855655038 0.429249042841818 no 1418 0.430670706358712 2033 3122360
SGTC_402 epigallocatechin gallate 10 µM 0.173678528335488 0.429636926521773 no 1419 0.431059056477982 1946 65064 An antioxidant.
SGTC_702 1488-0190 94 µM 0.173151299936225 0.429843872918169 no 1420 0.431266251179695 2129 949357
SGTC_716 1683-5115 658 µM 0.172973087537699 0.429913828773207 no 1421 0.431336290884528 2124 723597
SGTC_1288 0973-0013 65.5 µM 0.172410681044952 0.430134611373261 no 1422 0.431557337828628 2026 4315430
SGTC_1249 0481-0015 10.2 µM 0.172037975808838 0.430280935435288 no 1423 0.431703836843946 1988 4227577
SGTC_1813 st051246 8.6015 µM 0.171491012953126 0.430495690362807 no 1424 0.431918848196344 2107 5291959
SGTC_676 falcarinol 140 µM 0.168940385351206 0.431497417946504 no 1425 0.432921766404796 2114 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1312 1218-2183 165 µM 0.168480397169584 0.431678119735292 no 1426 0.433102682010771 2126 6744073
SGTC_1808 st050063 61.5 µM 0.168341756526934 0.431732586140655 no 1427 0.433157212806504 2102 4011993
SGTC_1313 1220-0047 237 µM 0.167983591606302 0.431873300925939 no 1428 0.433298093821888 2040 3528706
SGTC_3034 9090421 49.47 µM 0.16775605269911 0.431962700236825 no 1429 0.433387598650116 2117 17173761
SGTC_824 1304-0008 100 µM 0.16697021318239 0.432271480844599 no 1430 0.433696743156887 2002 768245
SGTC_2659 sanguinarine 24.21 µM 0.163554945633489 0.433613923151416 no 1431 0.435040757574127 2035 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1930 st074634 34.3 µM 0.163278442919916 0.43372264205764 no 1432 0.435149603089921 2037 684253 YOR116C RPO31
SGTC_2321 7390090 138.78 µM 0.162887279859664 0.433876453162141 no 1433 0.435303593134956 1946 649046
SGTC_714 4296-0578 26.1 µM 0.158209587567762 0.435716560345754 no 1434 0.437145824558613 2123 1589775
SGTC_2545 solidagenone 89.61 µM 0.158052825063275 0.435778251803723 no 1435 0.437207586706086 2090 6708572 An anti ulcer agent
SGTC_2202 7226349 200 µM 0.157923002419743 0.435829342679315 no 1436 0.437258736098515 2055 844334
SGTC_586 0957-0265 8.15 µM 0.157646662940961 0.435938097888374 no 1437 0.437367615791923 2138 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_425 3825-7017 13.1 µM 0.156026368781859 0.436575872461174 no 1438 0.438006118237194 2074 3397440
SGTC_2991 9074669 71.4286 µM 0.155485529106134 0.43678879269151 no 1439 0.43821928065158 2091 17333109
SGTC_1556 plumbagin 1.48 µM 0.155126719066813 0.436930060773257 no 1440 0.438360709192101 2123 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2253 7938677 135.83 µM 0.154239355514102 0.437279461607372 no 1441 0.438710506119919 2154 2301972
SGTC_2078 5212016 200 µM 0.1526882795765 0.437890317602075 no 1442 0.439322051962447 2177 1899708
SGTC_2566 crystal violet carbinol 226 nM 0.151576513388969 0.438328252609647 no 1443 0.439760479467436 1879 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1423 4048-0112 5.59 µM 0.149727391011585 0.439056806084761 no 1444 0.440489848438504 2144 X1423
SGTC_2421 5690543 90.72 µM 0.148183976448531 0.439665069032445 no 1445 0.441098788573001 2041 3397993
SGTC_161 4065-0411 162.148 µM 0.148178049100807 0.43966740528825 no 1446 0.441101127423361 2049 1906281 YLR208W SEC13
SGTC_108 0509-0257 621.132 µM 0.148028399649328 0.439726390105943 no 1447 0.441160177730991 2123 536624
SGTC_3305 9127027 53.8275 µM 0.147977409612382 0.439746488300414 no 1448 0.441180298233016 2048 41905295
SGTC_1774 st048371 48.465 µM 0.147690793492813 0.439859463581913 no 1449 0.441293398841211 2020 4242727
SGTC_1216 1165-0504 9.65 µM 0.147182846900683 0.440059692570243 no 1450 0.441493849666598 2161 6304004
SGTC_1588 farnesol 29.9 µM 0.14602836095377 0.440514839784591 no 1451 0.441949499801579 2001 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1963 st076565 50.3 µM 0.145826445014174 0.440594451685247 no 1452 0.442029199478479 2069 4914280
SGTC_2543 pimpinellin 60.67 µM 0.144847444121035 0.440980488492904 no 1453 0.442415661101234 1999 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2710 st078562 53.7235 µM 0.144737419056834 0.441023876771461 no 1454 0.44245909704251 2123 17250908
SGTC_2770 toltrazuril 17.5 µM 0.144630722765875 0.441065953027597 no 1455 0.442501219503872 2147 68591 Kills coccidiodes.
SGTC_2567 aureobasidin a 60 nM 0.144135210546887 0.441261369647406 no 1456 0.442696850507369 2041 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_206 4546-0025 72.014 µM 0.143529280081569 0.441500351669753 no 1457 0.442936094239071 2047 6620745 YIL048W NEO1
SGTC_492 tmb-8 126 µM 0.142836234461108 0.441773718455372 no 1458 0.443209759757115 2153 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2456 5770359 74.46 µM 0.142610734193995 0.441862671376272 no 1459 0.443298809739481 2126 3118787
SGTC_2280 7785178 200 µM 0.141213793328761 0.44241378675947 no 1460 0.443850524883896 2062 2954328
SGTC_1875 nocodazole 6 µM 0.141190307254745 0.442423053344821 no 1461 0.443859801530347 2182 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_3253 9135987 49.47 µM 0.140816742387204 0.442570450058431 no 1462 0.444007358174231 2099 4182430
SGTC_2533 agelasine 13.65 µM 0.139879854107317 0.442940151046362 no 1463 0.444377459437221 2175 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1750 st081859 2.357 µM 0.139698070763198 0.44301188946477 no 1464 0.444449275383863 2067 5291695
SGTC_1523 st012844 44.7 µM 0.139514429958843 0.443084362802491 no 1465 0.444521826996882 2042 4274103
SGTC_1615 st002656 86.5 µM 0.139375484345246 0.443139198571808 no 1466 0.444576721960419 2171 1584458
SGTC_743 1275-0778 158 µM 0.139246474449798 0.443190114121868 no 1467 0.444627692448591 2147 2849257 YMR203W TOM40
SGTC_2635 hydroquinidine 100 µM 0.139230132232049 0.443196563872417 no 1468 0.44463414915678 2057 442912 An experimental heart treatment.
SGTC_890 0929-0006 47.2 µM 0.138850971967017 0.443346210521372 no 1469 0.444783957130974 1996 1378169
SGTC_3349 9149703 23.001 µM 0.138402085866837 0.443523386947802 no 1470 0.4449613242995 2156 4910494
SGTC_479 n-linoleoylglycine 10 µM 0.138351997180437 0.443543157774011 no 1471 0.44498111639273 2041 6433346 An anti-infammatory.
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.138041768220977 0.443665613362349 no 1472 0.445103703625086 2118 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_728 3030-5151 22.5 µM 0.137796980219366 0.443762241468657 no 1473 0.445200435514403 2084 3125388
SGTC_3156 9099931 49.47 µM 0.13431557877142 0.445136856081205 no 1474 0.446576517393898 2077 18111053
SGTC_409 arachidonic acid 100 µM 0.133527247773574 0.445448217013211 no 1475 0.446888208302308 2133 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_931 2812-0076 566 µM 0.133266742394945 0.445551114193137 no 1476 0.446991214338794 2063 3450959
SGTC_1923 st058458 19.1 µM 0.132619433502111 0.445806810997082 no 1477 0.447247181234159 2201 3534982
SGTC_1114 scopoletin 1.73284 µM 0.132134122015856 0.445998531166399 no 1478 0.44743910352905 2178 5280460 A coumarin with genotoxic properties.
SGTC_1087 pterostilbene 9.05 µM 0.131207481899922 0.446364631304384 no 1479 0.447805588713955 2158 5281727 Similar to reservatol, lowers cholesterol.
SGTC_237 nikkomycin 200 µM 0.131096724796044 0.446408392664094 no 1480 0.447849396018741 2167 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_190 3970-0790 3.722 µM 0.130918327752552 0.446478880685991 no 1481 0.447919958009654 2167 2832352
SGTC_1922 5578187 25 µM 0.129052441439013 0.44721622833737 no 1482 0.448658076729312 2164 1350412
SGTC_2066 5222451 176 µM 0.128217090572857 0.447546395624882 no 1483 0.448988587689858 2171 2281147
SGTC_2634 4'-methoxyflavone 100 µM 0.128034636281466 0.447618514404987 no 1484 0.449060781407621 2053 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1255 0566-0045 221 µM 0.1273368078574 0.447894361280178 no 1485 0.449336914477502 2089 2788469
SGTC_2266 7929956 200 µM 0.12686735783346 0.44807994589925 no 1486 0.449522691255691 2185 2967153
SGTC_3332 9141069 11.198 µM 0.125554156220587 0.4485991455678 no 1487 0.450042426861715 2085 17332883
SGTC_1412 3909-8563 178 µM 0.125281862680648 0.448706813138205 no 1488 0.450150205265294 2205 23767530
SGTC_2224 6650123 117.647 µM 0.124435110473461 0.449041651476447 no 1489 0.450485387616237 2137 2908370
SGTC_3227 9130768 49.47 µM 0.120755376679656 0.450497178060245 no 1490 0.451942397812253 2169 17720899
SGTC_993 3909-8757 62.7 µM 0.120294623883186 0.450679477137008 no 1491 0.452124881353891 2095 4288324 YLR208W SEC13
SGTC_668 1682-0499 62.6 µM 0.118855852971569 0.451248800623062 no 1492 0.452694778989162 2073 682214
SGTC_1510 1123-0200 71.5 µM 0.118662623092763 0.451325269598079 no 1493 0.452771324857631 2176 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_465 cgp-37157 41 µM 0.118178050212578 0.451517042866554 no 1494 0.452963290730854 2195 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_837 0091-0265 12.5 µM 0.116231009140327 0.452287712264564 no 1495 0.453734730778848 2070 759367
SGTC_2812 7970281 58.44 µM 0.115911641142865 0.452414140369686 no 1496 0.453861284794889 2177 2233435
SGTC_780 0109-0199 192 µM 0.115474404966928 0.452587236734463 no 1497 0.454034553312934 2215 610414
SGTC_2404 5161160 200 µM 0.115164348176102 0.452709989824876 no 1498 0.454157428323008 2123 2831543
SGTC_1847 st056231 15 µM 0.11384768904392 0.453231312207828 no 1499 0.454679266966585 2209 5393180
SGTC_1546 5-methoxyflavanone 78.7 µM 0.11382437398818 0.453240544377326 no 1500 0.454688508256405 2207 147795
SGTC_3344 9148862 3.898 µM 0.11306785170255 0.453540121660912 no 1501 0.454988381068373 2174 4905352
SGTC_829 1635-0120 117 µM 0.112677416148002 0.453694741635059 no 1502 0.455143153254259 2200 285054
SGTC_1757 st041620 31.8375 µM 0.112580833052327 0.453732991478711 no 1503 0.455181440718548 2087 5289815
SGTC_2921 7974240 10.71 µM 0.112120523110749 0.453915294107543 no 1504 0.455363922468777 2152 2979074 YDR527W RBA50
SGTC_1044 1222-0021 1.78 µM 0.111770101435217 0.454054082746038 no 1505 0.455502847271871 2128 4306703
SGTC_1400 3771-8998 51.5 µM 0.111214220075776 0.454274257618797 no 1506 0.455723237798187 2169 670767
SGTC_1939 st074455 53.6 µM 0.110407278786266 0.454593897919778 no 1507 0.456043190392801 2216 1644229
SGTC_1877 wortmannin 25 µM 0.109057094470848 0.455128789751286 no 1508 0.456578602748009 2217 312145 A covalent inhibitor of PI 3-kinase.
SGTC_21 0849-0113 22.993 µM 0.108699450155843 0.455270488537966 no 1509 0.456720438992091 2161 1560156
SGTC_2245 6637752 200 µM 0.106972324893209 0.45595485587159 no 1510 0.457405467642 2207 681890
SGTC_3170 9103054 49.47 µM 0.105882774987957 0.456386653565315 no 1511 0.457837680401212 2123 16432970
SGTC_1478 0453-0656 35.7 µM 0.104609693235987 0.456891251676016 no 1512 0.458342761410852 2206 5258496
SGTC_433 pimozide 108 µM 0.104121680273021 0.45708469875008 no 1513 0.458536392999813 2165 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_562 3772-2733 112 µM 0.099165031026258 0.459050069992927 no 1514 0.460503619583266 2215 2876874 YIL048W NEO1
SGTC_328 k915-0120 63.5 µM 0.098864682850576 0.45916919432766 no 1515 0.460622855244276 2227 6624543
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.0981485568945707 0.459453239552013 no 1516 0.46090716539897 2084 688788
SGTC_2057 5236571 38.335 µM 0.0981320799057554 0.459459775252598 no 1517 0.460913707186796 2202 54684039 YBR257W POP4
SGTC_1242 0402-0103 60.1 µM 0.097865906513765 0.459565356108758 no 1518 0.461019386325331 2209 432868
SGTC_373 0844-0104 25.9 µM 0.0974307810622705 0.459737959955848 no 1519 0.461192150626265 2259 5375804
SGTC_1725 st036284 20.55 µM 0.0972774818828943 0.459798771878762 no 1520 0.461253019015828 2227 707914
SGTC_508 roscovitine 141 µM 0.0972386737815691 0.459814166730538 no 1521 0.46126842815709 2234 160355 A CDKinase inhibitor.
SGTC_3084 9116877 49.47 µM 0.0968626807991424 0.459963323142929 no 1522 0.461417722904643 2251 27241325
SGTC_369 0957-0393 4.5 µM 0.0968196127863834 0.459980408583227 no 1523 0.461434824177915 2138 6997992
SGTC_2865 9030313 51.95 µM 0.0963052909349365 0.460184450058298 no 1524 0.461639054531685 2181 42562754
SGTC_793 0488-0545 106 µM 0.0960119275043765 0.460300837732629 no 1525 0.461755549774959 2051 292548
SGTC_1437 4092-1038 11.6 µM 0.0956847539670648 0.460430643086686 no 1526 0.461885474953546 2205 3977136
SGTC_156 3474-0145 5.642 µM 0.0956621354973108 0.460439617068927 no 1527 0.461894457214085 2246 2265471
SGTC_758 0868-0029 16 µM 0.0938900728494171 0.461142753366463 no 1528 0.462598239860113 2262 762687
SGTC_231 b-estradiol 524 µM 0.092583319037704 0.4616613378397 no 1529 0.463117298150663 2175 450 A steroid.
SGTC_316 k060-0003 58.6 µM 0.0922736454594587 0.461784241202876 no 1530 0.463240313448461 2218 6152314
SGTC_3288 9119690 36.221 µM 0.0918492479393646 0.461952682171666 no 1531 0.463408907601886 2149 17595618 YKL019W RAM2
SGTC_356 1634-0012 32.5 µM 0.0918455078900676 0.4619541666064 no 1532 0.463410393385454 2256 735457
SGTC_2657 nystatin 74.44 µM 0.0894065024830869 0.462922325745117 no 1533 0.464379427967516 2199 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1999 st074831 12.5 µM 0.0892364086278416 0.462989852478338 no 1534 0.464447015442108 2101 17112523
SGTC_448 monastrol 171 µM 0.0890288679455404 0.463072246930143 no 1535 0.464529483952738 2209 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_531 3788-1495 174 µM 0.0888211765376137 0.463154702806581 no 1536 0.464612013881261 2130 2896655
SGTC_1225 1216-0074 20.6 µM 0.0884915752246474 0.463285561564852 no 1537 0.464742990034116 2155 4241466
SGTC_2728 chlorpromazine 9.18 µM 0.0878067807207769 0.463557452288629 no 1538 0.465015124174396 2263 2726 A thorazine and dopamine antagonist.
SGTC_1026 k007-1105 30.6 µM 0.0860108903420786 0.46427057291335 no 1539 0.465728880034485 2250 7066794
SGTC_729 4092-0585 94.1 µM 0.0845488584791322 0.464851208296967 no 1540 0.466310029212131 2184 2169061
SGTC_722 3534-0461 190 µM 0.0842082742845288 0.464986479642092 no 1541 0.466445419814732 2168 658262
SGTC_2296 7971656 126.45 µM 0.0835997130348898 0.46522819469515 no 1542 0.466687347552069 2183 666570
SGTC_2892 9047358 58.44 µM 0.0830925746496316 0.465429635303918 no 1543 0.466888965000434 2183 6466771
SGTC_1664 st014217 9.02 µM 0.0829571444312981 0.465483431087414 no 1544 0.466942807947224 2265 3982782
SGTC_996 3970-0799 1.8 µM 0.0827791716429193 0.465554126649922 no 1545 0.467013565449066 2221 6615648 YGL040C HEM2
SGTC_869 0564-0080 44.1 µM 0.0825100785333031 0.465661019710463 no 1546 0.467120552076445 2105 6843321
SGTC_2110 5483698 200 µM 0.0819564914546584 0.465880931366639 no 1547 0.467340655900151 2169 2848765 YHR062C RPP1
SGTC_2432 5630864 12.22 µM 0.0813611582404233 0.466117438239084 no 1548 0.467577368948949 2187 5714970
SGTC_1403 3909-7815 62.9 µM 0.0777859945018239 0.467537985397329 no 1549 0.468999143729505 2205 6615483
SGTC_2026 5148700 152 µM 0.077244547418131 0.467753159210473 no 1550 0.469214501885931 2242 79838
SGTC_1575 cyproterone acetate 48 µM 0.0760319704489294 0.468235077524448 no 1551 0.469696831532859 2180 9880 An androgen receptor antagonist and liver toxin.
SGTC_3012 9080433 71.4286 µM 0.0725133999954284 0.469633735160418 no 1552 0.471096670944211 2270 17688859
SGTC_684 1140-0066 328 µM 0.0719817162149012 0.469845116393236 no 1553 0.471308229224059 2193 6813534
SGTC_2010 4012422 159 µM 0.0710344280959585 0.470221750239191 no 1554 0.471685177514793 2237 952393
SGTC_2969 9091408 28.7 µM 0.0709153220147288 0.470269107714922 no 1555 0.471732574436547 2068 4286311
SGTC_2406 ethylparaben 405.7 µM 0.0705411156391779 0.470417897723538 no 1556 0.471881488245033 1966 8434 A possible steroid mimic.
SGTC_2268 7933382 153.85 µM 0.0688216846955407 0.471101621754529 no 1557 0.472565778559402 2302 935025 YOR257W CDC31
SGTC_2792 7535235 81.82 µM 0.0678840731219328 0.471474494828342 no 1558 0.472938958655664 2208 1281891
SGTC_2621 lithochol-11-enic acid 100 µM 0.067731386495784 0.471535218225141 no 1559 0.472999731931343 2283 6708711
SGTC_2416 tofa 880 nM 0.0669478885020835 0.471846825374821 no 1560 0.473311594507283 2033 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_589 1227-0070 34.1 µM 0.0663929565095415 0.472067539346531 no 1561 0.473532488861429 2235 2841384
SGTC_205 1486-1330 71.903 µM 0.0649227448578048 0.472652330221004 no 1562 0.474117755508664 2278 4118834
SGTC_2300 7976697 71.57 µM 0.0647393073354065 0.472725298428401 no 1563 0.474190782861442 2230 2236109
SGTC_1474 0330-0125 5.35 µM 0.0645986812251998 0.4727812376319 no 1564 0.474246767374183 2299 X1474
SGTC_499 genistein 192 µM 0.063864268896805 0.473073385823307 no 1565 0.474539151731652 2297 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1148 3909-7663 27.7 µM 0.0633734756696342 0.473268630762873 no 1566 0.474734554066678 2297 4084526
SGTC_883 0850-0245 24.6 µM 0.0628987973061944 0.473457471076622 no 1567 0.47492354628034 2241 6823229 YPR165W RHO1
SGTC_709 3807-1509 243 µM 0.0614912012842432 0.474017487004643 no 1568 0.475484010752716 2294 1886677 YPL242C IQG1
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.0614320562821321 0.474041019137379 no 1569 0.475507561670524 2314 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2544 sphondin 68.51 µM 0.0611459477517066 0.474154854951483 no 1570 0.475621488284991 2282 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_939 1165-0479 45.3 µM 0.0607587852332801 0.474308901114398 no 1571 0.475775657132504 2312 1377347
SGTC_2998 9066762 71.4286 µM 0.0591614403058308 0.474944501082817 no 1572 0.476411760999456 2262 4945196
SGTC_1937 st074714 47.2 µM 0.0583983506439343 0.475248164913648 no 1573 0.476715664263765 2290 17250970
SGTC_3341 9147222 25.867 µM 0.0577859423459965 0.475491877024465 no 1574 0.47695956792493 2235 1939759
SGTC_2413 inermin 26.06 µM 0.0576683686589887 0.475538667337069 no 1575 0.477006394950911 2284 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1779 st039427 55 µM 0.0573746646931581 0.475655552958737 no 1576 0.477123372197453 2321 1124498
SGTC_853 0419-0306 21 µM 0.055530297620612 0.476389604802457 no 1577 0.477857996585343 2206 762713
SGTC_940 3232-1287 54.8 µM 0.0552219533719983 0.476512332653661 no 1578 0.477980819678657 2321 1585493 YIL048W NEO1
SGTC_450 aminopyrene 156 nM 0.0551650262808811 0.476534991142773 no 1579 0.478003495736604 2304 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_3325 9138760 55.175 µM 0.0550797413440296 0.476568936947065 no 1580 0.478037467852809 2284 43844959
SGTC_2364 9055074 200 µM 0.055059249186743 0.476577093427542 no 1581 0.478045630653922 2246 6470630
SGTC_1969 st069479 40.1 µM 0.0546101376537309 0.476755855466971 no 1582 0.478224531066491 2312 3895485
SGTC_1778 st046819 58.9 µM 0.0538756969674008 0.477048198514978 no 1583 0.478517099773807 2316 671715
SGTC_2907 7721985 69.9 µM 0.0538050375449225 0.4770763250493 no 1584 0.478545247977559 2273 3267881
SGTC_2159 5658611 73.75 µM 0.0523056671310676 0.477673187838432 no 1585 0.479142568891386 2316 793844
SGTC_772 k072-0172 35.3 µM 0.0513324666601022 0.478060622095494 no 1586 0.479530298772483 2221 5861980
SGTC_1508 1080-0625 72.9 µM 0.0511478669698504 0.478134114180277 no 1587 0.479603846778209 2311 767111
SGTC_1906 st060206 94.7 µM 0.0509573359484614 0.478209968402441 no 1588 0.479679758666604 2302 5133468
SGTC_1704 st028805 70.8 µM 0.0499436749187153 0.478613540399353 no 1589 0.480083636579066 2228 2876101
SGTC_512 prima-1 270 µM 0.0498804226670247 0.478638723944852 no 1590 0.480108839164533 2307 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_78 0336-0123 156.75 µM 0.0488614147733445 0.479044448168965 no 1591 0.480514869331419 2168 6765896
SGTC_2176 5809774 33.9695 µM 0.046630164616819 0.479932909312355 no 1592 0.481403995142516 2322 2870539
SGTC_2164 5685496 200 µM 0.0461570116396671 0.480121326983062 no 1593 0.48159255283672 2323 759046
SGTC_972 1319-0219 195 µM 0.0456344889149205 0.480329409697449 no 1594 0.481800789808941 2259 23903702
SGTC_662 k832-1615 104 µM 0.0455612631117229 0.480358570626927 no 1595 0.48182997232442 2281 5878478
SGTC_2377 9073351 62.6 µM 0.0454811575809766 0.480390471411162 no 1596 0.481861896713829 2295 7337946 YHR072W ERG7
SGTC_836 0330-0104 1.35 µM 0.0450145915836437 0.48057627656707 no 1597 0.482047839171099 2336 46494820
SGTC_2217 6934799 96.0675 µM 0.0446576404500382 0.480718431571565 no 1598 0.482190099006831 2317 675606
SGTC_571 k831-0106 44.2 µM 0.0444906869887239 0.480784921263371 no 1599 0.482256637667116 2340 4783639
SGTC_2643 anethole 100 µM 0.0437796582157202 0.481068096462571 no 1600 0.482540020963765 2312 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_429 1112-0049 25.5 µM 0.0411529743176224 0.482114284564968 no 1601 0.483586971472521 2276 2836170
SGTC_554 4483-2211 187 µM 0.0409842668647779 0.482181483739421 no 1602 0.483654219273348 2275 747107
SGTC_2022 5136654 200 µM 0.0405714792007429 0.482345906527293 no 1603 0.483818760864554 2302 1713771
SGTC_1818 st052136 56.3 µM 0.0392364220173728 0.482877710822113 no 1604 0.484350947706268 2280 674169
SGTC_3037 9091026 49.47 µM 0.0384373345453471 0.483196032533996 no 1605 0.48466949715096 2335 25236398 YIL048W NEO1
SGTC_1967 st070177 51.4 µM 0.0384311516504314 0.483198495572577 no 1606 0.484671961947997 2315 5729214
SGTC_3208 9114115 49.47 µM 0.0384145307948079 0.483205116715077 no 1607 0.484678587817301 2233 650895
SGTC_285 1486-1325 46 µM 0.0382657575964156 0.483264382735671 no 1608 0.484737896129632 2333 22310230
SGTC_117 lucigenin 22.078 µM 0.0379474367558865 0.483391191826477 no 1609 0.48486479560149 2259 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1428 4049-0204 61.7 µM 0.0371242196605065 0.483719143590935 no 1610 0.485192980419975 2337 X1428
SGTC_1317 1273-0028 910 nM 0.034219245492318 0.484876508562818 no 1611 0.486351159921911 2336 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_3113 9123498 49.47 µM 0.0342134200841168 0.484878829583366 no 1612 0.48635348256352 2352 8897275
SGTC_3009 9080819 71.4286 µM 0.034034645415068 0.484950059120443 no 1613 0.486424761824936 2306 17027216
SGTC_418 lividomycin a 100 µM 0.0336219971183805 0.485114473208953 no 1614 0.486589290509678 2355 72394 An antibiotic.
SGTC_2267 7931562 200 µM 0.0323810170447844 0.485608939938501 no 1615 0.487084100376478 2337 934880
SGTC_675 1309-0189 238 µM 0.0322436067332119 0.485663692254554 no 1616 0.487138890549205 2318 4246530
SGTC_777 1315-0167 517 µM 0.0311306464204638 0.486107170697424 no 1617 0.48758267459953 2206 4221767
SGTC_2926 9010726 65.15 µM 0.0309056664678392 0.486196819987878 no 1618 0.487672385447732 2326 2994293
SGTC_1657 st012939 43.4 µM 0.0299278368192508 0.486586470458458 no 1619 0.48806230260879 2333 24207257
SGTC_1759 st043059 70 µM 0.0290060456030092 0.486953802185729 no 1620 0.488429884465218 2331 669426
SGTC_826 1683-5028 118 µM 0.0287048703262254 0.487073822270631 no 1621 0.488549986005555 2316 722377
SGTC_176 1486-1328 72.834 µM 0.0283037557655705 0.487233670552666 no 1622 0.48870994256679 2323 22310231
SGTC_718 1130-0073 349 µM 0.0281269263496636 0.487304139548329 no 1623 0.488780459222187 2323 6740020
SGTC_966 1300-0360 30.2 µM 0.0268404294332363 0.487816838358975 no 1624 0.489293503399181 2346 70588
SGTC_1158 4092-0494 91.8 µM 0.0267277731697706 0.487861735459633 no 1625 0.489338430627786 2308 1148199
SGTC_1626 st003712 1.76 µM 0.0251653554355767 0.488484424182308 no 1626 0.489961535278377 2328 24207035
SGTC_1762 st045503 25.4615 µM 0.0250695609551325 0.488522603212465 no 1627 0.489999739693611 2345 4645554
SGTC_2097 5376186 200 µM 0.0246984769382227 0.488670500279314 no 1628 0.490147734969192 2359 742755
SGTC_2462 5162487 171.77 µM 0.0241547958050831 0.488887189447033 no 1629 0.49036456766018 2358 2259986
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.0229838183872247 0.489353904435432 no 1630 0.490831590298472 2342 165506
SGTC_158 k038-0087 26.446 µM 0.0229086258789584 0.489383874323259 no 1631 0.490861579872951 2305 X158
SGTC_192 3455-0609 60.9 µM 0.0227810092439568 0.489434739318102 no 1632 0.490912478260998 2322 3769639
SGTC_1201 1889-3372 45.9 µM 0.021366507038786 0.489998538012209 no 1633 0.49147664548713 2314 5392199
SGTC_2469 5655019 90.81 µM 0.0210457072824928 0.490126406652201 no 1634 0.491604597299775 2364 2788239
SGTC_1950 st077106 7.18 µM 0.0200759511531956 0.490512951084022 no 1635 0.4919913922393 2282 13831864
SGTC_294 k038-0071 157 µM 0.0199617177264345 0.490558485079 no 1636 0.492036955652277 2341 24152826
SGTC_2952 9073731 13.78 µM 0.018446933422971 0.491162296814247 no 1637 0.492641155672256 2365 16457353
SGTC_1868 st057644 42.7 µM 0.0175237861680983 0.491530284733924 no 1638 0.493009378570258 2377 688665
SGTC_654 1124-0271 80.9 µM 0.0164352461332482 0.491964211291656 no 1639 0.49344358059704 2361 5403748
SGTC_1066 ketoconazole 628 nM 0.0160306275966337 0.492125507515992 no 1640 0.493604978771353 2367 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2218 6965428 192.983 µM 0.0151645632451565 0.492470757756957 no 1641 0.493950446421809 2376 675684
SGTC_2628 lathosterol 100 µM 0.012870969964617 0.493385108561922 no 1642 0.494865367660526 2372 6710616
SGTC_1399 3562-5772 25 µM 0.012443428987695 0.493555553594513 no 1643 0.495035918169482 2384 23847490
SGTC_3201 9113999 49.47 µM 0.0120741976225987 0.493702753654246 no 1644 0.495183209103686 2378 16649224
SGTC_3135 9127742 49.47 µM 0.0107501144891689 0.494230627734659 no 1645 0.495711407413113 2354 3643468
SGTC_1096 rimcazole 32.2 µM 0.0100145661884644 0.494523874231734 no 1646 0.496004832907895 2387 18528119 A dopamine reuptake inhibitor.
SGTC_3148 9097893 49.47 µM 0.00996554184930983 0.494543419235611 no 1647 0.496024389813625 2374 17174100
SGTC_1695 st026914 34.495 µM 0.00969875880234717 0.494649780422176 no 1648 0.496130815706155 2389 3289191
SGTC_2782 7736369 71.43 µM 0.00914597676757771 0.494870165017241 no 1649 0.496351334039725 2389 2950836 YOL077C BRX1
SGTC_282 k297-0036 65.7 µM 0.0091009013683714 0.494888135865862 no 1650 0.496369315773883 2369 5061378
SGTC_911 3456-4043 236 µM 0.00891425448789425 0.494962549134568 no 1651 0.496443774085199 2382 914281
SGTC_378 3970-0959 8.33 µM 0.00844858489997741 0.495148205265922 no 1652 0.496629542370303 2383 6615653
SGTC_523 1934-0222 13.7 µM 0.00751061013931021 0.49552216619492 no 1653 0.497003728233425 2388 1361595
SGTC_3211 9128781 49.47 µM 0.00455154309868097 0.496701940154322 no 1654 0.498184203286375 2378 17194361
SGTC_405 ebelactone b 50 µM 0.00393531905423458 0.496947631388339 no 1655 0.49843003889466 2392 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_3065 9113888 49.47 µM 0.00357064302246854 0.497093029875754 no 1656 0.498575522557011 2393 16648368
SGTC_3282 9108498 15.4605 µM 0.00320799031727137 0.497237622033896 no 1657 0.498720199222437 2396 16459645
SGTC_1784 st039334 36.3 µM 0.0029282894287912 0.497349140974109 no 1658 0.498831783207156 2399 3496984
SGTC_1030 k029-0042 36.7 µM 0.00163459275456188 0.497864950552973 no 1659 0.499347892129361 2395 6080581
SGTC_2352 9027995 87.8 µM 0.00143045841103238 0.497946341270179 no 1660 0.499429329854102 2385 2997347
SGTC_1213 1315-0166 115 µM 0.00126182668946645 0.498013576747149 no 1661 0.499496604116618 2399 768401
SGTC_2696 st077691 74.316 µM 0.000258386598250666 0.498413661371126 no 1662 0.499896918662416 2404 757133
SGTC_1776 st049249 45.9 µM 0 0.498516683745142 no 1663 0.5 2404 1822314
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.41318283625005e-05 0.498522318306959 no 1664 0.499994362216167 2406 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_322 k048-0136 19.3 µM -0.000255393538646492 0.498618512841395 no 1665 0.4998981127204 2408 6823282
SGTC_1516 st013856 110 µM -0.000307318486444357 0.498639216080021 no 1666 0.499877397664138 2406 5281404 A mutagen and neurotoxin.
SGTC_1161 k007-0610 110 µM -0.000773859247791311 0.498825232885254 no 1667 0.49969127485779 2408 5843850
SGTC_1338 1486-1223 76 µM -0.000817568391828921 0.498842660390853 no 1668 0.499673837437715 2412 3444526
SGTC_314 1671-0008 2.74 µM -0.00228381082364818 0.49942727479017 no 1669 0.499088892094033 2412 3913060
SGTC_2465 5809242 33.21 µM -0.00293183584546104 0.499685653237265 no 1670 0.498830368397676 2413 2731748
SGTC_1011 4112-3381 17.4 µM -0.00304632496087114 0.49973130198498 no 1671 0.498784694052959 2437 2877139
SGTC_3091 9116372 49.47 µM -0.00306031933130028 0.499736881777538 no 1672 0.498779111132932 2439 17169793
SGTC_105 0111-0055 734.78 µM -0.00310509423440664 0.499754734290245 no 1673 0.498761248615858 2433 5179370
SGTC_1497 4476-2978 41.3 µM -0.00324735439720054 0.499811455831242 no 1674 0.498704495308426 2431 1528379
SGTC_1700 st030840 7.9285 µM -0.00354605593806062 0.499930553215448 no 1675 0.498585331322435 2415 5499307
SGTC_2190 6049624 200 µM -0.00367001658341509 0.499979978435312 no 1676 0.498535878501816 2405 2265554
SGTC_2912 7964298 10.93 µM -0.003770446528713 0.499979978435312 no 1677 0.498495813027692 2415 2975850
SGTC_120 rhodamine 6G 52.259 µM -0.00377970995746872 0.499976284948527 no 1678 0.498492117480633 2410 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_288 1315-0019 35.1 µM -0.00465887626156073 0.499625746426805 no 1679 0.49814138400369 2417 6811474
SGTC_1199 1638-0010 4.46 µM -0.00487390402546006 0.499540011242698 no 1680 0.498055601311807 2408 3111136
SGTC_2310 7668677 200 µM -0.00687141844553641 0.498743570203225 no 1681 0.49725872222797 2422 2197143
SGTC_3203 9113543 49.47 µM -0.00762900293000325 0.498441510255544 no 1682 0.496956497696771 2449 17018012
SGTC_828 2074-0507 139 µM -0.00766761557138357 0.49842611485654 no 1683 0.496941093932109 2430 X828
SGTC_1236 0330-0013 258 µM -0.00786603725245674 0.498347001400549 no 1684 0.496861937521845 2429 4617066
SGTC_1567 st069303 68.4 µM -0.00983716448908983 0.497561089867712 no 1685 0.496075602460005 2431 5581319
SGTC_1192 1488-0095 21.4 µM -0.00991256884360305 0.497531025436303 no 1686 0.496045521941527 2444 915875
SGTC_2329 6138490 200 µM -0.0100268560934212 0.497485458052493 no 1687 0.495999930191344 2472 720019
SGTC_505 gw-5074 63.9 µM -0.0101041285775608 0.497454648816747 no 1688 0.495969104491896 2453 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1420 4'-methoxyflavone 42 µM -0.0108005942122512 0.497176962399377 no 1689 0.495691270086364 2419 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_439 amiodarone 34.4 µM -0.0114887031244221 0.496902609216832 no 1690 0.495416771400529 2453 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2970 9090938 41.86 µM -0.0119504892846482 0.496718493096936 no 1691 0.495232558029537 2429 17217104
SGTC_368 fentichlor 4.58 µM -0.0126726072968183 0.496430582968545 no 1692 0.494944496461482 2434 7329 A pesticide.
SGTC_3271 9137798 49.47 µM -0.014208948091031 0.495818046698985 no 1693 0.494331640581921 2435 6498326
SGTC_3099 9120367 49.47 µM -0.014425988300558 0.495731513925206 no 1694 0.494245062940189 2436 24824940
SGTC_3066 9117245 49.47 µM -0.0157598709134905 0.495199706606168 no 1695 0.493712981414852 2439 17176980
SGTC_1820 st053765 18.6 µM -0.0160000855731278 0.495103936003591 no 1696 0.493617161713347 2451 3690829
SGTC_417 st075190 100 µM -0.0162377781993461 0.495009171182165 no 1697 0.493522348393229 2431 222757
SGTC_1370 2001-0092 44.6 µM -0.0171970259305003 0.494626735058227 no 1698 0.493139717401531 2419 790957
SGTC_1799 st045822 46.1415 µM -0.017797936847761 0.494387164358492 no 1699 0.49290002532858 2438 3674992
SGTC_1453 4237-0541 195 µM -0.017849345223576 0.494366668999759 no 1700 0.492879519611312 2435 739892
SGTC_1052 3253-3998 198 µM -0.0178842631271996 0.494352748028443 no 1701 0.492865591606459 2434 5450317
SGTC_694 1315-0438 43.2 µM -0.0179921481095246 0.494309736791546 no 1702 0.492822558649723 2454 6793154
SGTC_2398 5228213 48.84 µM -0.0184022213853323 0.494146250708002 no 1703 0.49265899016716 2437 80771 YMR134W ERG29
SGTC_1089 terbinafine 2.25 µM -0.0197143927226356 0.493623127156845 no 1704 0.492135604639554 2440 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2407 paclitaxel 400 µM -0.0201858889203438 0.493435158325645 no 1705 0.491947542301874 2602 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1966 st070145 16.1 µM -0.020447557818863 0.493330840831749 no 1706 0.491843173057517 2440 3748532
SGTC_1275 0867-0008 21.1 µM -0.0213191493944369 0.492983373562561 no 1707 0.491495534151222 2444 3422836
SGTC_548 1436-0017 110 µM -0.0213987676667771 0.492951633333975 no 1708 0.491463778300518 2447 9677137
SGTC_3343 9148379 18.9835 µM -0.0215486546407907 0.492891880251872 no 1709 0.491403995834401 2450 1955036
SGTC_1659 st012954 42.1 µM -0.0234101021598355 0.492149819966418 no 1710 0.490661573428521 2479 24207262
SGTC_2856 9022925 19.48 µM -0.0249526565634816 0.491534905906342 no 1711 0.490046363213097 2483 4944862
SGTC_1268 0828-0275 2.46 µM -0.025002679771846 0.491514965302121 no 1712 0.49002641306454 2490 745337
SGTC_3345 9148410 3.559 µM -0.0254620501314462 0.491331848846454 no 1713 0.489843209137054 2456 4903596
SGTC_150 3970-0969 77.2 µM -0.0257627561294377 0.491211980940222 no 1714 0.489723284142498 2535 6615640
SGTC_2090 5301565 104.445 µM -0.0259542944678833 0.491135630034238 no 1715 0.48964689694402 2456 2056344
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.0268442436524064 0.490780883289989 no 1716 0.489291982293972 2469 279621
SGTC_859 0439-0102 54.6 µM -0.0296913941262543 0.489646017886511 no 1717 0.488156587694906 2456 610143
SGTC_1371 2421-0008 32.7 µM -0.0303631730683122 0.489378260751272 no 1718 0.487888707469559 2489 2827552
SGTC_603 3794-0023 45.9 µM -0.0304294675495556 0.489351837405352 no 1719 0.487862272013199 2465 3802260
SGTC_1432 4049-0298 68.4 µM -0.030765604727783 0.489217862134259 no 1720 0.487728235439245 2477 741646
SGTC_1597 7-benzyloxygramine 47.5 µM -0.0308821992728799 0.489171390956618 no 1721 0.487681743037332 2463 260807
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.0318162295870261 0.488799119133939 no 1722 0.487309301924927 2491 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_532 1548-0774 215 µM -0.0319334394094426 0.488752404079666 no 1723 0.487262565719256 2537 5932993
SGTC_374 0880-0231 82.3 µM -0.0319927344891442 0.488728771538256 no 1724 0.487238922485456 2474 6833587
SGTC_296 1222-0039 74.9 µM -0.0330510758145631 0.48830696763871 no 1725 0.486816928628386 2492 5984176
SGTC_3013 9080133 71.4286 µM -0.0338804183853736 0.487976440734055 no 1726 0.48648625404381 2497 17050193
SGTC_2072 5231554 129 µM -0.0341827656040531 0.487855945054431 no 1727 0.48636570478261 2487 789545
SGTC_2887 9044784 58.44 µM -0.0371325916930018 0.486680398590974 no 1728 0.485189642763544 2483 6465546
SGTC_1204 4049-0315 18.3 µM -0.0371975715216349 0.486654504496488 no 1729 0.485163737459476 2655 588402
SGTC_1961 st076550 68.7 µM -0.0387083679258243 0.486052476757366 no 1730 0.484561450885444 2515 1579337
SGTC_2775 cyproheptadine 69.59 µM -0.0392184841380705 0.4858492108722 no 1731 0.484358098380921 2478 2913 A selective serotonin reuptake inhibitor.
SGTC_1483 3453-0561 55.9 µM -0.0408906304890472 0.485182937174913 no 1732 0.483691543494131 2540 4546991
SGTC_1945 st075991 56.6 µM -0.0415389517884152 0.484924621871181 no 1733 0.483433120300727 2506 1084980
SGTC_566 0958-0068 16.5 µM -0.042766704388087 0.484435457022489 no 1734 0.482943752871671 2489 6815365
SGTC_3062 9077494 49.47 µM -0.0428458416546259 0.484403927712662 no 1735 0.482912210582027 2484 16459633
SGTC_475 α-linolenic acid 10 µM -0.0431120579425444 0.484297864419655 no 1736 0.482806103694426 2540 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_906 1165-0455 526 µM -0.043378268150672 0.484191804659858 no 1737 0.482700000447825 2469 3252859
SGTC_2920 7982904 15.77 µM -0.0459957602371083 0.483149040691405 no 1738 0.481656814587767 2537 6456808
SGTC_2114 5491910 81.25 µM -0.046097873750767 0.483108362707921 no 1739 0.481616120354844 2537 2849228
SGTC_1503 4585-0012 61.3 µM -0.0462267981970889 0.483057004560889 no 1740 0.481564741714384 2590 2922052
SGTC_1980 st071811 45.7 µM -0.0472043807262657 0.482667585474802 no 1741 0.48117516805074 2616 4974850
SGTC_1348 1493-0373 93.8 µM -0.0472273152874687 0.482658449710858 no 1742 0.481166028677642 2519 3010129
SGTC_3100 9120536 49.47 µM -0.0478236438734132 0.482420911110596 no 1743 0.480928396513273 2470 16421196
SGTC_636 0kpi-0074 126 µM -0.0481414908834882 0.482294304037669 no 1744 0.480801739789324 2537 616434
SGTC_3249 9135183 49.47 µM -0.0488396979374167 0.48201619554431 no 1745 0.480523522764129 2623 4902779
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.0492714681300878 0.481844218040581 no 1746 0.480351478512743 2535 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.049618138312287 0.481706138992045 no 1747 0.480213346075945 2590 94937 An inhibitor of serotonin biosynthesis.
SGTC_1301 naphtanilide LB 4.81 µM -0.0496853407876655 0.481679372438471 no 1748 0.480186569193985 2513 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1767 st044992 70.3 µM -0.050151377825625 0.481493753499113 no 1749 0.480000878816769 2518 9600693
SGTC_3250 9135583 49.47 µM -0.0501968646749921 0.481475636653891 no 1750 0.479982755016531 2597 7699353
SGTC_2800 7887935 81.82 µM -0.0515479698766776 0.480937525898166 no 1751 0.479444439099645 2557 2961002
SGTC_1613 st002381 52.1 µM -0.0524419173502983 0.480581508442362 no 1752 0.479088287416764 2524 551167
SGTC_2917 7979103 53.79 µM -0.053404731875289 0.480198081794144 no 1753 0.478704717551919 2541 2980565
SGTC_655 k060-0012 42 µM -0.0539544486156404 0.479979173424039 no 1754 0.478485728041059 2498 5994525
SGTC_1169 aniline yellow 25.8 µM -0.0541351869366062 0.479907201069813 no 1755 0.478413729108817 2537 6051 A DNA damaging agent.
SGTC_1804 st050076 49.1 µM -0.054579861763902 0.479730128553269 no 1756 0.478236591412003 2559 3895976
SGTC_1529 apigenin 74 µM -0.0546509131147719 0.479701835795685 no 1757 0.478208288267444 2535 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1719 st032227 49.2 µM -0.0546783351788885 0.479690916314771 no 1758 0.47819736477975 2526 3125804
SGTC_2716 st080858 38.6235 µM -0.0548843781615298 0.479608870374578 no 1759 0.478115288769913 2512 5296050
SGTC_245 methotrexate 289.6 µM -0.0572604167125519 0.478662799459844 no 1760 0.477168875739514 2550 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_950 1165-0508 94.1 µM -0.0578404154551259 0.478431878520457 no 1761 0.476937872585725 2545 6148369
SGTC_616 4092-0450 108 µM -0.0579338768055419 0.478394668455051 no 1762 0.476900649319874 2553 787165
SGTC_295 k015-0027 31 µM -0.0593269891969219 0.477840046679948 no 1763 0.47634583234971 2563 3887424
SGTC_2885 9057732 51.95 µM -0.0595756422066145 0.477741058163461 no 1764 0.476246809302417 2586 6471414
SGTC_2737 bleomycin 30.5 nM -0.0604632330571177 0.477387720368944 no 1765 0.475893349010546 2512 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2021 4019055 173 µM -0.0611121720257189 0.477129397862005 no 1766 0.475634937698021 2579 44827708 YER133W GLC7
SGTC_1885 st057546 99.9 µM -0.061319783850239 0.477046756047859 no 1767 0.475552267607446 2657 702008
SGTC_2902 5787006 60.46 µM -0.0626450964386464 0.476519226482186 no 1768 0.475024559075306 2524 591003
SGTC_463 ikarugamyin 104 µM -0.0635632887566263 0.47615377180148 no 1769 0.474658981965517 2522 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1177 0983-0204 23.6 µM -0.0674717791667747 0.474598360568152 no 1770 0.473103063888756 2542 766818
SGTC_2317 5986382 200 µM -0.0695404768823015 0.473775262925241 no 1771 0.472279707362683 2558 877883
SGTC_2311 7694451 200 µM -0.0720136573460684 0.472791376076845 no 1772 0.471295519540462 2586 2163142
SGTC_1407 3909-7909 12.3 µM -0.0724979357052068 0.472598738491262 no 1773 0.471102824108328 2547 4411780
SGTC_2375 9072683 200 µM -0.0734385428601436 0.472224599527811 no 1774 0.47072857380851 2521 16798029
SGTC_2940 9060638 45.86 µM -0.0737420475690684 0.472103881720602 no 1775 0.470607820363409 2593 4027022
SGTC_3041 9091929 49.47 µM -0.0751934753751502 0.471526617627794 no 1776 0.470030387777903 2610 25236887
SGTC_290 2043-6722 48.1 µM -0.0756098888281332 0.471361012019584 no 1777 0.46986473442046 2590 773758 YLR208W SEC13
SGTC_892 0929-0076 29 µM -0.0757508912354927 0.471304937167703 no 1778 0.469808643459886 2544 5751038
SGTC_101 0490-5701 117.494 µM -0.0760540857130541 0.471184362534583 no 1779 0.469688034290974 2547 4661669
SGTC_2479 5617353 43.85 µM -0.0766170610640974 0.470960485040592 no 1780 0.469464093041232 2598 2731746
SGTC_2777 climbazole 1.536 µM -0.0774271907585152 0.470638338203092 no 1781 0.469141855304137 2546 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1134 3477-0009 42.5 µM -0.0776654955320821 0.470543580321099 no 1782 0.469047070873458 2646 3973534
SGTC_81 0411-0046 9.971 µM -0.0790485816885729 0.469993652491531 no 1783 0.468496990664883 2534 12925265
SGTC_2629 bisabolol 100 µM -0.0790585755029775 0.469989679065613 no 1784 0.468493016148505 2615 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_862 0452-0056 10.2 µM -0.0790821079917229 0.46998032282995 no 1785 0.468483657345732 2550 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1115 galangin 695.678 nM -0.0796605004788617 0.469750366127431 no 1786 0.468253637812435 2550 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2045 5106652 78.05 µM -0.0797473265869953 0.46971584675986 no 1787 0.468219109056889 2591 673349
SGTC_377 3970-0964 33.1 µM -0.080116907140919 0.469568915544133 no 1788 0.468072138009032 2547 16481235
SGTC_2705 st078069 42.8 µM -0.0819095432498886 0.468856290552757 no 1789 0.467359322763244 2614 1530061
SGTC_1814 st052110 31.539 µM -0.081943330438248 0.468842860113456 no 1790 0.467345888785043 2574 674163
SGTC_1734 st037168 69.4 µM -0.0821973470788181 0.468741889395151 no 1791 0.467244891516454 2643 708907
SGTC_1372 2752-0194 270 µM -0.0822872296409667 0.46870616187509 no 1792 0.467209154625235 2557 823334
SGTC_1962 st076595 64.5 µM -0.0830556555253239 0.468400729728183 no 1793 0.466903642864355 2555 279619
SGTC_664 1222-0054 14.9 µM -0.0838748145396807 0.468075152779204 no 1794 0.466577982035322 2580 6813991
SGTC_2093 5331342 194.4 µM -0.0838971291939446 0.468066284057739 no 1795 0.466569111043186 2587 33839
SGTC_2003 4023581 200 µM -0.0849891552146747 0.467632289408729 no 1796 0.466135006199665 2638 16641307
SGTC_1840 st055363 71 µM -0.0852794469738921 0.467516927665872 no 1797 0.466019615469591 2605 676033
SGTC_730 1436-0052 41.2 µM -0.0853463755797552 0.467490330671193 no 1798 0.465993011809937 2559 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2989 9073649 71.4286 µM -0.0855654675482099 0.467403265957142 no 1799 0.465905925325708 2539 21367202
SGTC_2270 7924575 90.91 µM -0.0864796806599775 0.467039984700978 no 1800 0.465542554017631 2741 1262135
SGTC_1231 0242-0792 125 µM -0.0867812341235773 0.466920162278415 no 1801 0.46542270217074 2552 3707635
SGTC_1492 4158-0558 28.5 µM -0.0870372768085451 0.466818425939825 no 1802 0.465320940957359 2663 3967268
SGTC_1958 st076513 41.9 µM -0.0897353450529194 0.465746504999534 no 1803 0.464248763971504 2570 732122 YGL099W LSG1
SGTC_1756 st041558 35.5 µM -0.0915670258349382 0.465018933990314 no 1804 0.463521025461683 2628 3955792
SGTC_1736 st036774 51 µM -0.0924903261268257 0.464652229475772 no 1805 0.463154238454423 2760 1272247
SGTC_2691 st077356 60.2 µM -0.0938891805010987 0.464096707814883 no 1806 0.462598594289942 2689 2839272
SGTC_3000 9075062 71.4286 µM -0.0953515387159704 0.463516041959371 no 1807 0.462017803561723 2606 17057871
SGTC_5 0352-0601 109.883 µM -0.0956766705502371 0.463386950760365 no 1808 0.461888685042747 2551 762456
SGTC_825 1988-2224 89.6 µM -0.0958988308536933 0.463298745865146 no 1809 0.461800461572773 2581 1180859
SGTC_991 3996-0057 64.7 µM -0.0960658318644703 0.463232442198038 no 1810 0.461734143992361 2648 715343
SGTC_1973 st070275 50.2 µM -0.0961520418410344 0.463198215034817 no 1811 0.461699909663414 2535 17118334
SGTC_3205 9113483 49.47 µM -0.0980435008625753 0.46244733525686 no 1812 0.460948875523623 2709 17018033
SGTC_2320 7373003 200 µM -0.0986932891359058 0.46218941017468 no 1813 0.460690898672828 2618 5415828
SGTC_2136 5328288 199.296 µM -0.100511032463001 0.461467965173575 no 1814 0.459969312276971 2611 262395
SGTC_962 1254-0300 21.5 µM -0.100718358646099 0.461385687397862 no 1815 0.459887018694831 2573 7340576
SGTC_2568 diosmetin 100 µM -0.102000598280061 0.460876865103022 no 1816 0.459378100101605 2571 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_609 0986-0026 86.3 µM -0.102269775703479 0.460770057391784 no 1817 0.45927127249367 2585 2848610
SGTC_1480 1070-0044 41.2 µM -0.10305289462378 0.460459337425363 no 1818 0.458960495271247 2685 3124987
SGTC_547 1120-0019 610 nM -0.103939169289728 0.460107717239212 no 1819 0.458608811417459 2581 3676939
SGTC_3068 9116768 49.47 µM -0.103939270499096 0.460107677087232 no 1820 0.458608771258277 2668 41904888
SGTC_1837 st055472 66.5 µM -0.104957456109678 0.459703761141719 no 1821 0.4582047836508 2735 676091
SGTC_2694 st077685 81.9 µM -0.10697955358276 0.458901715378001 no 1822 0.457402600266048 2594 2838096
SGTC_2900 5328528 85.29 µM -0.107449470620175 0.458715351079515 no 1823 0.457216204880764 2587 795359
SGTC_568 1193-0097 7.48 µM -0.109072740225158 0.4580716489949 no 1824 0.45657239800824 2618 3646150
SGTC_1195 1502-0147 41.1 µM -0.109650957170399 0.457842385487015 no 1825 0.456343098147602 2599 817940
SGTC_1256 0570-0116 285 µM -0.10975396115874 0.457801545788219 no 1826 0.456302252026554 2628 410638
SGTC_3274 9138298 49.47 µM -0.110928113754406 0.457336041635104 no 1827 0.455836675812251 2583 17015756
SGTC_967 1306-0166 352 µM -0.112075997048136 0.45688100877385 no 1828 0.45538157454044 2633 4437607
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.115629317389752 0.455472796638165 no 1829 0.45397316341501 2633 641818 YHR062C RPP1
SGTC_1996 st072960 66.8 µM -0.11648179400206 0.455135035166719 no 1830 0.453635357077456 2594 1719405
SGTC_71 0417-1750 47.813 µM -0.117240133219731 0.454834599309725 no 1831 0.453334882243568 2657 6811472
SGTC_1055 3448-0672 86 µM -0.117615998148635 0.454685700180862 no 1832 0.453185964122347 2742 748378
SGTC_1540 guanosine 70.6 µM -0.117707152880529 0.454649590134785 no 1833 0.453149849502823 2593 6802 Guanosine is a purine nucleoside
SGTC_1163 k060-0048 49.9 µM -0.118925750853731 0.454166890703351 no 1834 0.452667090152984 2613 6809982
SGTC_516 3992-2719 87.3 µM -0.11901694438104 0.454130770704568 no 1835 0.452630965761638 2584 5350887 YDR037W KRS1
SGTC_989 1501-0895 10.3 µM -0.119147730176685 0.454078969633493 no 1836 0.45257915841316 2611 2830112
SGTC_1471 k673-0312 37 µM -0.120500120179004 0.453543366821667 no 1837 0.452043492225192 2618 24099884
SGTC_1748 st037455 53.6035 µM -0.120504126387668 0.45354178032108 no 1838 0.452041905541024 2748 580690
SGTC_3289 9119912 71.43 µM -0.121591727735924 0.453111106302983 no 1839 0.451611182593463 2715 17014829
SGTC_3181 9108277 49.47 µM -0.12191554560712 0.452982889855147 no 1840 0.45148295192746 2636 17097298
SGTC_2685 mycophenolic acid 18.85 µM -0.122386259225119 0.452796518435808 no 1841 0.451296560126395 2667 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3214 9129694 49.47 µM -0.123246302796568 0.452456025023189 no 1842 0.450956030350462 2698 17158655
SGTC_936 3005-4620 401 µM -0.124786020459695 0.451846534412372 no 1843 0.450346477468309 2715 777207
SGTC_1241 0364-0022 50.8 µM -0.125070315203827 0.451734009929411 no 1844 0.450233941884589 2713 4563895
SGTC_135 0933-0004 26.348 µM -0.126430757758546 0.451195597614564 no 1845 0.449695478162507 2721 21230617 YGL099W LSG1
SGTC_1908 st060353 56.5 µM -0.126514139813872 0.45116260102336 no 1846 0.449662478512729 2754 4227716
SGTC_731 3966-0296 387 µM -0.126537521736669 0.451153348208779 no 1847 0.449653224842377 2637 660956
SGTC_2848 9016370 25.97 µM -0.126910193633095 0.451005876157911 no 1848 0.449505739264877 2635 7894410
SGTC_2382 9035899 200 µM -0.12733367239671 0.450838307250945 no 1849 0.449338155245386 2661 6462679
SGTC_897 1000-0139 31.4 µM -0.128255492432078 0.450473576966778 no 1850 0.448973393014378 2711 6151020
SGTC_1282 0886-0010 32.4 µM -0.128392571887723 0.450419343232372 no 1851 0.448919154640485 2699 2836211 YNL267W PIK1
SGTC_2199 6590217 200 µM -0.129428083879867 0.450009686131815 no 1852 0.448509463422812 2663 703109
SGTC_2255 7941087 197.44 µM -0.131007354226078 0.44938501643715 no 1853 0.447884744858876 2730 935561
SGTC_2374 9071832 200 µM -0.132693157533114 0.448718346781957 no 1854 0.447218027254369 2631 17381698
SGTC_1600 coumarin 106 71.1 µM -0.134259828411199 0.448098919116132 no 1855 0.446598558931471 2805 100336 A hepatotoxic, DNA x-linker.
SGTC_3026 9090633 49.47 µM -0.134316866074726 0.448076370039781 no 1856 0.446576008445877 2635 25236842
SGTC_386 1509-0011 3.07 µM -0.135106821522519 0.447764089018156 no 1857 0.446263708419263 2642 3107280
SGTC_704 1310-0270 142 µM -0.13536169584914 0.447663340341801 no 1858 0.4461629538151 2718 5718033
SGTC_1735 st034310 56.75 µM -0.13610880757304 0.447368035774705 no 1859 0.445867632445432 2865 871153
SGTC_2815 7968870 71.43 µM -0.136698479439628 0.447134981727625 no 1860 0.445634565740593 2668 2977326 YHR190W ERG9
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.138906554637306 0.446262454318454 no 1861 0.444761995667032 2989 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2395 5646831 180.19 µM -0.13928625637365 0.446112440155382 no 1862 0.444611974920304 2781 6808628
SGTC_2429 5902844 64.44 µM -0.139514391450747 0.44602231129506 no 1863 0.444521842210605 2799 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_146 3448-8650 53.125 µM -0.139628053208855 0.445977408216361 no 1864 0.444476937243836 2688 2891488 YIL048W NEO1
SGTC_2549 cedrol 20.94 µM -0.139795113770215 0.445911410727824 no 1865 0.444410937016142 2735 6708665 A sedative which affects the nervous system.
SGTC_2370 9071495 200 µM -0.140308331395152 0.445708672829512 no 1866 0.444208190970558 2708 21791103
SGTC_3049 9092223 49.47 µM -0.141090639076998 0.445399662806971 no 1867 0.443899169305643 2759 8623917
SGTC_273 hydroxyurea 18.1 mM -0.141755675291762 0.445137000863247 no 1868 0.443636498202415 2659 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_3054 9094397 49.47 µM -0.141977506707659 0.445049391931529 no 1869 0.443548886366193 2696 2598354
SGTC_95 0471-0001 561.058 µM -0.142368898435441 0.444894824290491 no 1870 0.443394313784481 2672 4015405
SGTC_1058 3448-5425 97.3 µM -0.143306001785569 0.444524779390813 no 1871 0.443024258009491 2638 7279705
SGTC_2747 doxorubicin 7.63 µM -0.143403189803555 0.444486404389314 no 1872 0.442985881957136 2636 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2497 7-hydroxyflavone 100 µM -0.144106516172115 0.444208709241407 no 1873 0.44270817963593 2840 5281894
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.145453624981219 0.443676905318295 no 1874 0.442176364090373 2685 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.145748674139482 0.443560441002054 no 1875 0.442059897599865 2628 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1150 3909-7983 10.9 µM -0.145810621919082 0.443535989065847 no 1876 0.442035445224103 2689 23965914
SGTC_987 1497-1013 404 µM -0.146119327363874 0.443414140514857 no 1877 0.441913594570365 2665 1676435
SGTC_29 0299-0004 12.984 µM -0.147341767980152 0.442931685907639 no 1878 0.441431133070974 2652 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2220 6782180 200 µM -0.148425964232357 0.442503862290108 no 1879 0.441003305257339 2681 833803
SGTC_2536 dehydroabietamide 32.04 µM -0.148525030860894 0.442464773954184 no 1880 0.440964216627842 2794 3983547
SGTC_1667 st014849 34.6 µM -0.150161752437602 0.44181906041001 no 1881 0.440318500410754 2642 5348460
SGTC_1332 1480-0653 17.5 µM -0.150469475580391 0.441697675787759 no 1882 0.440197115744537 2636 5749438
SGTC_2203 7227154 166.4 µM -0.15092909212133 0.441516385420469 no 1883 0.440015825581873 2672 896304
SGTC_866 0495-0101 262 µM -0.151757575584903 0.441189630782869 no 1884 0.439689072130987 2686 635694
SGTC_2032 5185112 25.99 µM -0.152344778040374 0.440958061822311 no 1885 0.439457504648626 2758 5718189
SGTC_846 0335-0850 148 µM -0.152776687826843 0.440787746905712 no 1886 0.43928719115663 2679 6819598
SGTC_648 0375-0473 33.3 µM -0.155207173846191 0.439829538857241 no 1887 0.438328996456454 2701 1713139
SGTC_68 0986-0284 82.829 µM -0.155238656145873 0.439817129403471 no 1888 0.438316587234985 2904 423278 YIL048W NEO1
SGTC_1003 4049-0218 100 µM -0.156418721763864 0.439352022852291 no 1889 0.437851490486868 2830 295161
SGTC_2807 7945238 51.95 µM -0.156791719728153 0.439205028241424 no 1890 0.437704499418502 2789 17148797
SGTC_1383 3049-0032 20.7 µM -0.15744550643299 0.438947397950188 no 1891 0.437446875850946 2833 712864
SGTC_555 4296-0685 37 µM -0.159240300298993 0.438240277216112 no 1892 0.436739776942528 2657 2908540 YHR072W ERG7
SGTC_1768 st044301 37.178 µM -0.160039603287239 0.437925427640934 no 1893 0.436424938676134 2734 3931349
SGTC_3001 9076041 71.4286 µM -0.160327156166376 0.437812168677016 no 1894 0.436311684020074 2701 16004211
SGTC_394 menadione 8.33 µM -0.160371482821735 0.437794710111397 no 1895 0.436294226129789 2679 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1391 3442-0225 151 µM -0.160452579037502 0.437762769742811 no 1896 0.43626228700453 2684 5227075
SGTC_2052 5265182 7.135 µM -0.161362454956635 0.437404435956989 no 1897 0.435903967859339 2821 1239884
SGTC_451 chloral hydrate 100 µM -0.161703928805164 0.437269967537636 no 1898 0.435769505261975 2806 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2068 5226020 147 µM -0.166596689297281 0.435344058661442 no 1899 0.43384369942597 2733 1810509
SGTC_1366 1683-0113 21.9 µM -0.166721091207159 0.435295110847925 no 1900 0.433794754710461 2696 708623
SGTC_985 1493-0307 8.71 µM -0.168154370487356 0.434731237129635 no 1901 0.433230918395568 2784 3278274
SGTC_1644 st010134 20.9 µM -0.169084252636748 0.434365478365109 no 1902 0.432865185580729 2728 3818134
SGTC_170 4197-0004 226 µM -0.169092985786536 0.434362043543898 no 1903 0.432861751009508 2854 218692
SGTC_1267 0828-0272 9.49 µM -0.16912748842251 0.434348473415649 no 1904 0.43284818187005 2830 745334
SGTC_1005 4092-0690 4.4 µM -0.170914506885313 0.433645732669752 no 1905 0.432145494830249 2750 1529343
SGTC_707 0865-0008 204 µM -0.171516665879054 0.433408982208768 no 1906 0.431908763567987 2730 723043
SGTC_2249 haloperidol 116.36 µM -0.171667279870425 0.433349769135722 no 1907 0.431849555383811 2693 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1427 4048-4900 550 nM -0.171904699177288 0.433256432062625 no 1908 0.431756226087796 2836 24132586
SGTC_576 1073-0113 22.7 µM -0.172311866344193 0.433096370381747 no 1909 0.431596177945359 2736 5439563
SGTC_1294 1000-1494 117 µM -0.17231701842925 0.43309434511337 no 1910 0.431594152849917 2732 712797 YDL207W GLE1
SGTC_3095 9117207 49.47 µM -0.17262689989652 0.432972534919697 no 1911 0.431472353132492 2855 17015229
SGTC_2038 4100038 30.985 µM -0.173246322321251 0.432729067480891 no 1912 0.431228907075433 2811 3596803
SGTC_1476 4112-3294 3.34 µM -0.173254091017678 0.432726014113384 no 1913 0.431225853979823 2823 704369
SGTC_1603 st002045 67.8 µM -0.173850415276311 0.432491649970685 no 1914 0.430991510983737 2787 5887985
SGTC_1130 3454-2858 15.9 µM -0.173871474732669 0.432483373730457 no 1915 0.430983235500266 2829 715628 YIL048W NEO1
SGTC_3334 9142812 21.919 µM -0.174388325786458 0.432280263655242 no 1916 0.430780144210589 2838 45283678
SGTC_1636 st007707 68.9 µM -0.174785321103884 0.432124266160419 no 1917 0.430624161422766 2849 403051
SGTC_1356 1502-0781 85.8 µM -0.177029430150568 0.431242653436261 no 1918 0.429742636370659 2711 567702
SGTC_3238 9133470 49.47 µM -0.179082146016339 0.430436530517356 no 1919 0.428936600397782 2863 3534688
SGTC_3310 9130229 44.1445 µM -0.179973138524162 0.430086718472428 no 1920 0.428586828099538 2881 7761258
SGTC_268 camptothecin 39.6153 µM -0.180493074388135 0.42988261209228 no 1921 0.42838274547481 2728 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2476 5806916 10.51 µM -0.182838351748903 0.428962182056207 no 1922 0.427462427733942 2742 2870194
SGTC_2107 5363541 170.161 µM -0.186033803359591 0.427708714159811 no 1923 0.426209126384306 2748 244052
SGTC_185 k048-0037 25.491 µM -0.186146959638115 0.427664340063557 no 1924 0.426164758472092 2776 6827589
SGTC_916 4466-0038 42 nM -0.187447322026156 0.427154470352899 no 1925 0.425654961232357 2843 5722064 YGL116W CDC20
SGTC_2265 7929201 200 µM -0.187483097662066 0.427140444507399 no 1926 0.425640937417231 2711 1265108
SGTC_2120 5538279 151.968 µM -0.187556368691239 0.427111718872678 no 1927 0.42561221594697 2763 2058197
SGTC_2927 9011802 47.9 µM -0.188137129393212 0.426884047481943 no 1928 0.425384577854979 2861 43912568
SGTC_2163 5671233 125 µM -0.189167527426173 0.426480168027503 no 1929 0.424980758749098 2875 701023
SGTC_2894 9048625 32.47 µM -0.189197325710898 0.42646848930239 no 1930 0.424969081793369 2867 4092861
SGTC_567 1080-0542 68.4 µM -0.189608593252018 0.426307309414595 no 1931 0.424807926464766 2742 5950415
SGTC_2755 lomerizine 42.69 µM -0.190437093058174 0.425982649401615 no 1932 0.424483316711499 2777 3949 A calcium channel blocker.
SGTC_55 0767-0285 6.563 µM -0.190579713626329 0.425926766458457 no 1933 0.424427442526068 2855 3116166
SGTC_2789 5281112 71.43 µM -0.191354806718428 0.425623088173399 no 1934 0.424123812379854 2804 765948
SGTC_2372 9071633 200 µM -0.192007523992499 0.425367390438239 no 1935 0.423868155895351 2769 21321366
SGTC_82 0054-0107 293.755 µM -0.193129594646378 0.424927899993512 no 1936 0.42342873788539 2820 3104697
SGTC_1907 st060210 83.7 µM -0.19586793009708 0.423855746816782 no 1937 0.42235676955684 2928 688793
SGTC_3251 9135047 49.47 µM -0.19847280026416 0.42283637263235 no 1938 0.42133758184134 2853 17682963
SGTC_1997 st073024 93.8 µM -0.199538569346895 0.42241944947776 no 1939 0.420920737966435 2842 686268
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.202373998613393 0.421310669119616 no 1940 0.419812176970987 2719 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1433 4060-0023 7.6 µM -0.206232097193768 0.419802982351937 no 1941 0.418304808386815 2891 3840627
SGTC_302 1094-0063 18.9 µM -0.206394353813661 0.41973960053338 no 1942 0.418241440447307 2765 5440289
SGTC_384 k007-0144 5.16 µM -0.207511401607702 0.419303308080653 no 1943 0.417805244633724 2835 6824886
SGTC_419 nsc-638432 893 µM -0.208419869430249 0.418948555150378 no 1944 0.417450571700442 2863 368090
SGTC_3218 9131285 49.47 µM -0.208591452962016 0.418881559879451 no 1945 0.417383591679906 2894 17156417
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.210349236773015 0.418195364086577 no 1946 0.416697554703807 2804 688801
SGTC_2816 7982706 58.44 µM -0.210399979865056 0.418175558911586 no 1947 0.41667775418341 2889 2981853
SGTC_903 1134-0042 114 µM -0.212963277232333 0.417175367565279 no 1948 0.415677803069075 2779 701009
SGTC_3276 9139060 49.47 µM -0.214005751695598 0.416768749874392 no 1949 0.415271285941514 2764 4870619
SGTC_2340 7987427 183.45 µM -0.214212360690615 0.416688172488829 no 1950 0.415190728683184 2906 2239331
SGTC_747 3448-8087 38.7 µM -0.215313690984302 0.416258713464692 no 1951 0.414761378043952 2856 5168703
SGTC_606 k015-0008 38.6 µM -0.215686925979252 0.416113194731258 no 1952 0.414615896460509 2928 1970475
SGTC_3255 9139072 49.47 µM -0.217714667785508 0.415322810016262 no 1953 0.413825717282011 2867 17646060
SGTC_2468 5987765 72.9 µM -0.218350732804045 0.415074951405338 no 1954 0.413577924433201 2843 26772094
SGTC_1903 st060211 78.3 µM -0.218357400820477 0.415072353225139 no 1955 0.413575326945662 2964 688960
SGTC_840 0245-0196 390 µM -0.218564165299169 0.414991789674479 no 1956 0.41349478490683 2922 3827528
SGTC_2162 5663267 200 µM -0.218736924416719 0.414924478687314 no 1957 0.413427491943437 2911 6456493
SGTC_3003 9075612 71.4286 µM -0.218967801209313 0.414834527595937 no 1958 0.413337565010067 2865 6501993
SGTC_23 0213-0011 39.996 µM -0.220344639892426 0.414298195208169 no 1959 0.412801378372487 2951 627608
SGTC_2911 7942208 15.64 µM -0.221137405529883 0.413989454475327 no 1960 0.412492722868499 2892 1243384
SGTC_2482 5981709 142.65 µM -0.22147769276656 0.413856946695534 no 1961 0.412360251965505 2859 877755
SGTC_43 0570-0105 72.5 µM -0.223173119502354 0.413196894322756 no 1962 0.411700385948749 2799 1114046 YDL195W SEC31
SGTC_1020 4335-0961 93.3 µM -0.224945360985248 0.412507199147665 no 1963 0.411010890242526 2767 669075
SGTC_2387 9077560 195.08 µM -0.226229412654042 0.412007659178904 no 1964 0.41051149777685 2806 5303272
SGTC_3339 9145883 14.936 µM -0.229995421355299 0.410543378144144 no 1965 0.409047663793279 2964 2030670
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.230567620654032 0.410321006958639 no 1966 0.408825362415348 2793 91467 include heat shock
SGTC_2648 atorvastatin 78.68 µM -0.231581616146097 0.409927013403488 no 1967 0.408431493786234 2916 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2477 5967686 25.23 µM -0.231582753609175 0.4099265714869 no 1968 0.408431052010659 2801 776118
SGTC_917 harmaline 728.087 nM -0.231933696890613 0.409790231729158 no 1969 0.408294755853609 2925 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1473 k844-0725 134 µM -0.233593277278752 0.409145640828124 no 1970 0.407650373666087 2848 54682906
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.23389257806417 0.409029416711561 no 1971 0.407534187634839 2863 676296 Flavone; oxidizing agent.
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.233909045472425 0.409023022339661 no 1972 0.407527795362318 2769 6708630 An antioxidant.
SGTC_1797 st048695 56.8 µM -0.234383390241189 0.408838842439682 no 1973 0.407343676111524 2950 592262 YIL048W NEO1
SGTC_3087 9117406 49.47 µM -0.234455386334014 0.408810889355839 no 1974 0.407315732262826 2944 42546093
SGTC_1459 k035-0031 35.7 µM -0.234683403868042 0.408722362706803 no 1975 0.407227234914087 2796 3877128 YMR208W ERG12
SGTC_2201 6605497 169.863 µM -0.235014213500433 0.408593935827916 no 1976 0.407098850684367 2861 670741
SGTC_2281 7943571 200 µM -0.235221693727158 0.408513392884796 no 1977 0.407018334574958 2995 1244024
SGTC_765 1319-0117 244 µM -0.235683188056868 0.408334256606526 no 1978 0.406839258216281 2801 3487746 YGL099W LSG1
SGTC_2964 9083345 53.42 µM -0.236824634786814 0.407891268466539 no 1979 0.406396419665524 2871 17741579
SGTC_2102 5377816 72.7585 µM -0.237067875354377 0.40779688356291 no 1980 0.406302066894202 3014 1379702
SGTC_992 3909-8734 162 µM -0.239388329216759 0.406896745080598 no 1981 0.40540223944964 2874 4288319
SGTC_885 0865-0106 16.8 µM -0.239581000212802 0.406822027181535 no 1982 0.405327547743012 2825 2793380
SGTC_820 1582-0060 59.9 µM -0.240651868878901 0.406406805712832 no 1983 0.404912472876054 2879 3848840
SGTC_1684 st024538 14.6195 µM -0.240667269943565 0.406400834829426 no 1984 0.404906504113708 2827 6732859
SGTC_2897 9048598 12.99 µM -0.240999394095269 0.406272077951964 no 1985 0.404777793064225 2839 6467404
SGTC_1008 4106-0037 6 µM -0.241104137971429 0.406231473267292 no 1986 0.404737202867193 2792 2905394
SGTC_2653 dihydrofissinolide 100 µM -0.241523145659829 0.406069052142575 no 1987 0.404574839863468 2888 6857746
SGTC_3069 9117009 49.47 µM -0.241822073960841 0.405953187605603 no 1988 0.404459016953452 2878 41904981
SGTC_2739 tacrine 100.86 µM -0.242538487128727 0.405675539580291 no 1989 0.404181469241555 2937 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2076 5212012 200 µM -0.243063388221857 0.405472142730089 no 1990 0.403978146381524 2785 604802
SGTC_2563 tomatine 8.54 µM -0.243206038275394 0.405416870874133 no 1991 0.403922894705536 2911 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_545 4218-0007 221 µM -0.244680207310259 0.404845793104912 no 1992 0.403352027280779 2961 2840508
SGTC_346 4513-0042 7.16 µM -0.24539325360947 0.404569638999207 no 1993 0.403075976095804 2839 2827372
SGTC_88 0180-0332 8.668 µM -0.245847032318403 0.404393920798852 no 1994 0.402900323793604 2807 3101745
SGTC_413 propylparaben 100 µM -0.246487206667559 0.404146056810476 no 1995 0.40265255330086 2832 7175 A pharmaceutical preservative.
SGTC_403 arphamenine a 50 µM -0.246547065109722 0.404122882664272 no 1996 0.402629387928455 2839 5487158 An arginine aminopeptidase inhibitor.
SGTC_804 1595-0054 20.9 µM -0.246613016132105 0.404097350170267 no 1997 0.402603865107539 2856 761523 Stimulates phospholipase C.
SGTC_1042 0350-0096 82 µM -0.247395940790195 0.403794277404667 no 1998 0.402300907675937 2821 3122515
SGTC_311 1315-0136 58 µM -0.250529966550367 0.402581665517981 no 1999 0.40108876673324 3018 6759207
SGTC_1988 st071872 53.4 µM -0.251737532113636 0.402114685654697 no 2000 0.400621972283373 2979 16414116
SGTC_2167 5876490 200 µM -0.252719901556572 0.401734894797409 no 2001 0.400242333884126 3075 686534
SGTC_1741 st038134 10.228 µM -0.253548089421476 0.401414783679804 no 2002 0.399922352426613 3085 1272587
SGTC_2013 4024628 200 µM -0.253803937394423 0.401315906703362 no 2003 0.399823515714408 3006 5230760
SGTC_1640 st009078 66.4 µM -0.2542356343784 0.4011490840947 no 2004 0.399656761267948 2986 690618
SGTC_1714 st033236 13.627 µM -0.25467708401985 0.400978511358163 no 2005 0.399486258523857 3024 2916566
SGTC_2160 5660466 132.927 µM -0.255047229844495 0.400835504412915 no 2006 0.399343310492003 2841 2859134
SGTC_865 0488-0499 301 µM -0.255661065769367 0.40059837636841 no 2007 0.399106280602124 2895 9634651
SGTC_641 4092-0595 30 µM -0.258608806305328 0.399460160456726 no 2008 0.39796854394788 2928 786260
SGTC_770 0389-1121 67.2 µM -0.259909642693383 0.398958137372796 no 2009 0.397466736517998 3050 6753108
SGTC_2828 7998861 71.43 µM -0.261372200379864 0.398393901847159 no 2010 0.396902746495459 2986 2988188
SGTC_1627 st003713 25.6 µM -0.262333574007661 0.398023132133841 no 2011 0.396532139908411 2938 16195070 YER133W GLC7
SGTC_1721 st082152 9.2685 µM -0.262748035548296 0.397863316536861 no 2012 0.396372395065841 2812 5296051
SGTC_1860 st056228 74.6 µM -0.262864881214911 0.397818264161335 no 2013 0.396327362684144 2981 688679
SGTC_1340 1486-1359 257 µM -0.263692948747752 0.397499023882525 no 2014 0.39600826468622 2878 4309068
SGTC_3176 9106582 49.47 µM -0.263758397610386 0.397473794670154 no 2015 0.395983046763372 2937 17018027
SGTC_3277 9138724 49.47 µM -0.264865630955486 0.3970470437014 no 2016 0.395556487760303 2938 15943418
SGTC_1449 4112-4002 201 µM -0.265555097184169 0.396781371178046 no 2017 0.395290935702412 2903 2059539
SGTC_3108 9121785 49.47 µM -0.265977432403517 0.396618656091743 no 2018 0.395128294760047 2804 17140271
SGTC_802 4112-3352 742 µM -0.266025839778783 0.396600007102817 no 2019 0.395109654286475 3020 704594
SGTC_2511 berberine 10.47 µM -0.266356967649828 0.396472446109703 no 2020 0.39498215163644 2882 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_47 0149-0135 24.25 µM -0.26646208594043 0.396431953515576 no 2021 0.394941677598032 2860 5239155
SGTC_629 3448-6466 76.7 µM -0.26693156504515 0.396251119212212 no 2022 0.394760926370531 2917 573744
SGTC_666 0272-0154 136 µM -0.267284108466565 0.396115340951429 no 2023 0.394625210710811 2914 6870312
SGTC_3350 9150499 3.57 µM -0.267288474173549 0.396113659625869 no 2024 0.394623530161637 2860 4910996 YPR165W RHO1
SGTC_3055 9094636 49.47 µM -0.267549956917964 0.396012960647828 no 2025 0.394522877737148 3044 25236176
SGTC_317 4495-0002 170 µM -0.267631660871488 0.395981497261281 no 2026 0.394491428917937 2921 15991618
SGTC_539 4859-0462 2.54 µM -0.269140325260144 0.395400647474072 no 2027 0.393910849915457 3043 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1090 efavirenz 20.7 µM -0.269936187767689 0.395094326534074 no 2028 0.393604673196506 2923 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_174 3553-0389 74.3 µM -0.271936310758386 0.394324782182283 no 2029 0.392835495482948 3025 738071
SGTC_976 1348-1067 47.6 µM -0.272960137622896 0.393931025660191 no 2030 0.392441928954281 2910 5310671 YGL099W LSG1
SGTC_980 1473-0395 201 µM -0.273309303409101 0.393796763754859 no 2031 0.39230773220305 2869 768876
SGTC_1938 st074717 56.4 µM -0.273533134005405 0.393710702618667 no 2032 0.392221712929457 2839 17250979
SGTC_3149 9097855 49.47 µM -0.273613865492998 0.393679663258667 no 2033 0.392190688686905 3048 25236625 YMR079W SEC14
SGTC_776 4476-4378 112 µM -0.275359789931712 0.393008561931368 no 2034 0.391519916679624 2977 2892008
SGTC_2857 9024691 58.44 µM -0.275399964627421 0.392993123249065 no 2035 0.391504485628815 2987 16478292
SGTC_1863 st057641 20.1 µM -0.277212088784291 0.392296919753886 no 2036 0.390808628869397 2895 3921635
SGTC_1481 3346-2004 36 µM -0.27729301269271 0.392265837462001 no 2037 0.390777562176138 2922 2770522
SGTC_22 0964-0034 14.468 µM -0.277898948811318 0.392033123605992 no 2038 0.390544965429258 2915 138402
SGTC_201 4262-0159 12.803 µM -0.277970210371679 0.39200575765896 no 2039 0.390517613290975 2970 1341029
SGTC_2600 tangeritin 87.95 µM -0.278179179310401 0.391925512245473 no 2040 0.390437408414294 2874 68077 A bioactive flavone.
SGTC_19 0279-0214 38.434 µM -0.27861050466222 0.391759895082812 no 2041 0.390271875128443 2904 3566274 YBR002C RER2
SGTC_1616 st002734 56.1 µM -0.27989490662288 0.391266836058602 no 2042 0.389779067518011 2899 4026101
SGTC_1557 sumaresinolic acid 42.3 µM -0.280056849347806 0.391204681516741 no 2043 0.389716944850257 2899 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_3224 9130643 49.47 µM -0.280333975477316 0.391098325372898 no 2044 0.389610643342096 3098 17644395
SGTC_672 1441-0018 53.7 µM -0.280440283185111 0.391057528501467 no 2045 0.389569867459746 2890 251141
SGTC_933 2914-0560 114 µM -0.280901082230962 0.390880705147353 no 2046 0.389393135279393 3098 463887
SGTC_70 0141-0289 43.283 µM -0.280995657457721 0.390844416392309 no 2047 0.389356865276199 2981 352408
SGTC_2960 9079389 5.97 µM -0.281961098283421 0.390474028721931 no 2048 0.388986669791308 3067 16457355
SGTC_2706 st078239 82.5 µM -0.282097729693372 0.390421618624758 no 2049 0.388934287004953 2902 15434492
SGTC_3348 9149464 3.537 µM -0.282422035841474 0.390297226822819 no 2050 0.388809960138988 2873 1951442
SGTC_1067 clotrimazole 1.36 µM -0.283802409434269 0.389767892515745 no 2051 0.388280903978671 2917 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_141 0443-0274 32.331 µM -0.285411306149198 0.389151184040305 no 2052 0.387664523280737 3046 1627241
SGTC_1788 fluconazole 20 µM -0.285886401284358 0.388969127966614 no 2053 0.387482564734561 3007 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1276 0871-0068 94.2 µM -0.285986090334275 0.388930930295683 no 2054 0.387444387570451 2995 3414906
SGTC_1070 indatraline 8.81 µM -0.286788590491336 0.388623476915947 no 2055 0.387137099810159 2920 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_37 0566-0070 1.56 µM -0.28719492379556 0.38846782933368 no 2056 0.386981536452199 3011 1626686
SGTC_335 4077-0256 27.6 µM -0.287384470280578 0.388395228925044 no 2057 0.386908975416574 2997 3121989
SGTC_1229 0139-0193 12.2 µM -0.287731375845128 0.388262366680906 no 2058 0.386776185370859 3062 3090752
SGTC_1780 st038448 24.544 µM -0.288831842269763 0.387840982842283 no 2059 0.386355031747261 3095 728868 YDL195W SEC31
SGTC_2513 baicalein 25.65 µM -0.289082767378925 0.387744918611493 no 2060 0.386259020261551 2963 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_3316 9136639 10.545 µM -0.28908579988969 0.38774375768633 no 2061 0.386257859974402 3013 4903665
SGTC_3257 9139206 32.98 µM -0.290618362726528 0.387157180795285 no 2062 0.385671607270216 3037 4910041
SGTC_86 0417-1630 471.922 µM -0.290997492158535 0.387012111549443 no 2063 0.385526618761069 2990 3634867
SGTC_849 0386-0493 241 µM -0.29196922817355 0.38664036074098 no 2064 0.385155075861453 2911 726119
SGTC_1373 2887-0003 58.5 µM -0.29257825768436 0.386407421225418 no 2065 0.384922267366251 2988 776948
SGTC_2783 7738165 71.43 µM -0.293944068235676 0.385885179632901 no 2066 0.3844003216019 2980 17201110
SGTC_904 1141-0088 396 µM -0.295669961063304 0.385225550063621 no 2067 0.383741069810654 2971 1378119
SGTC_2730 imipramine 71.33 µM -0.298439004245726 0.384167926668941 no 2068 0.382684061751207 2945 3696 A tricyclic antidepressant.
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.298459187500409 0.384160220921662 no 2069 0.38267636053073 2984 17037758
SGTC_782 0083-0095 30.5 µM -0.299635272971078 0.38371128343461 no 2070 0.382227687863204 2884 3591729 An indicator and reagent.
SGTC_701 4424-0219 185 µM -0.300361059855269 0.383434312566699 no 2071 0.381950881442217 3112 2911779
SGTC_1668 st014914 51.6 µM -0.300868834386602 0.383240573796174 no 2072 0.38175725818519 3001 2839556
SGTC_3162 9099653 49.47 µM -0.301110906608291 0.383148222655012 no 2073 0.38166496224719 3057 25237511
SGTC_2263 7948595 193.29 µM -0.30129183546173 0.383079202193718 no 2074 0.381595983102249 2916 2971371
SGTC_1981 st071826 47 µM -0.30171663275535 0.382917165765537 no 2075 0.381434043869671 3022 11838600
SGTC_1331 1472-0049 76.2 µM -0.30323386880172 0.382338592453625 no 2076 0.380855819885773 2923 24051409
SGTC_407 eburnamonine 100 µM -0.304943514821295 0.381686961410373 no 2077 0.380204586545231 2917 3195
SGTC_196 k015-0023 18.111 µM -0.306858185320669 0.380957583239624 no 2078 0.379475658891163 2935 5211998
SGTC_595 3909-8003 73.7 µM -0.307155648458679 0.380844304952674 no 2079 0.379362451081719 3072 699517
SGTC_2561 acetosyringone 100 µM -0.307248305847835 0.380809021757587 no 2080 0.379327189866458 2912 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_563 tetrahydrosecaminediol 614 µM -0.307559830075505 0.380690403085106 no 2081 0.379208645185351 3087 334274 A psychoactive constituent of the cannabis plant.
SGTC_3336 9143619 71.43 µM -0.307612674810781 0.380670282576645 no 2082 0.379188537242447 3060 45595730
SGTC_982 1491-0518 27.5 µM -0.3081418705111 0.380468810368193 no 2083 0.378987191094485 2946 3091256
SGTC_2040 5100729 123 µM -0.30872680318981 0.380246156033179 no 2084 0.378764676577289 2946 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2362 9071156 126 µM -0.310251025842598 0.37966614800143 no 2085 0.378185035251541 3116 653133
SGTC_2104 5389443 200 µM -0.310320413366665 0.379639750598846 no 2086 0.378158654623999 3124 2244536
SGTC_232 clozapine 119 µM -0.310421512164252 0.37960129014036 no 2087 0.378120218619717 2922 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2871 9038510 12.99 µM -0.311700218012095 0.379114942052138 no 2088 0.377634181128454 3153 4945164
SGTC_1434 4073-0095 163 µM -0.313699294702406 0.378354988779576 no 2089 0.376874718249007 2989 24133745
SGTC_2264 7948757 110.76 µM -0.315077789029292 0.377831224985311 no 2090 0.376351296034001 2908 2971411
SGTC_3118 9124250 49.47 µM -0.317425342588319 0.376939780894753 no 2091 0.375460440068193 3013 1504786
SGTC_1277 0873-0036 22 µM -0.317709427411118 0.376831948822614 no 2092 0.375352679715272 3044 5965735
SGTC_460 trequinsin 123 µM -0.319374054561933 0.376200287935403 no 2093 0.374721441452637 3048 5537 A vasodilator.
SGTC_1844 rapamycin 4 nM -0.320123385027629 0.375916054421554 no 2094 0.374437399508094 2936 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1197 1601-0112 267 µM -0.320678900493442 0.375705381597719 no 2095 0.374226869234769 2957 7350313
SGTC_1196 1588-0294 184 µM -0.3248294591148 0.374132506689735 no 2096 0.372655073688032 3024 6144269
SGTC_640 3381-0960 37.1 µM -0.325341731716139 0.373938523010065 no 2097 0.372461224971592 3041 1745025
SGTC_2309 7664088 163.95 µM -0.326033169968843 0.373676744807905 no 2098 0.372199629543277 3161 704922
SGTC_797 k781-0471 270 µM -0.32612593291785 0.373641629228856 no 2099 0.372164538538158 2978 23738129
SGTC_3320 9137005 35.139 µM -0.326364355867143 0.373551378611779 no 2100 0.372074351139583 3024 4908713
SGTC_2062 5245942 200 µM -0.326675959995604 0.373433437061455 no 2101 0.371956492337018 2966 1376160
SGTC_2460 5552655 174.22 µM -0.327478570649 0.373129705124181 no 2102 0.371652974188713 3106 5401989
SGTC_597 k018-0003 82.8 µM -0.333009926107314 0.371038627258747 no 2103 0.369563395221246 3113 6786234
SGTC_2667 digitoxin 100 µM -0.334137739460236 0.37061273248508 no 2104 0.369137811529156 3068 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2286 7945697 125 µM -0.335450206456089 0.370117306767159 no 2105 0.368642750152051 3050 1245733
SGTC_1456 k015-0012 13 µM -0.335473246302876 0.370108611683389 no 2106 0.368634061486485 3198 2989616
SGTC_1787 fluconazole 80 µM -0.336561666390901 0.369697924953015 no 2107 0.368223678835007 3083 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1895 st058434 18.3 µM -0.336670339468321 0.369656928173026 no 2108 0.368182712510109 3156 5393175
SGTC_1335 1486-0900 202 µM -0.337726102246938 0.369258720193861 no 2109 0.367784801294863 2957 X1335
SGTC_1866 st057638 64 µM -0.33908601923617 0.368745999375942 no 2110 0.367272465116916 3015 688802
SGTC_3122 9126309 49.47 µM -0.339719149629431 0.368507373882929 no 2111 0.367034019613193 3081 17591206
SGTC_1174 0739-0097 51.1 µM -0.339920086139837 0.368431651936023 no 2112 0.366958354910831 3039 728447
SGTC_1669 st015249 58.4 µM -0.340131793313781 0.36835187664458 no 2113 0.366878639995622 3096 722793
SGTC_94 0334-0113 514.748 µM -0.340148141595896 0.368345716536805 no 2114 0.366872484552872 3027 6795178
SGTC_2616 abietic acid 100 µM -0.340235534465716 0.368312787076175 no 2115 0.366839580036585 3168 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1696 st025591 34.7925 µM -0.340752429558193 0.368118041814647 no 2116 0.366644982537312 3007 2787147
SGTC_1947 st076332 61.6 µM -0.341439348443482 0.367859290878219 no 2117 0.366386428565389 3118 24208416
SGTC_2288 7946289 167.31 µM -0.344274769678101 0.366791870446771 no 2118 0.365319828373067 3203 1246052
SGTC_2650 prasterone 100 µM -0.345202734675932 0.366442752613772 no 2119 0.364970981507335 3052 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2589 lobaric acid 100 µM -0.345716022783216 0.366249691445142 no 2120 0.364778070753592 3022 73157 A novel microtubule depolymerizer.
SGTC_727 3032-0951 202 µM -0.345761877359435 0.366232445978345 no 2121 0.364760838742603 3068 3652836
SGTC_3136 9095672 49.47 µM -0.345930951922651 0.366168860989863 no 2122 0.364697303394468 2974 17217380
SGTC_2743 auranofin 4.32 µM -0.346103185477376 0.366104091756916 no 2123 0.364632584771754 3038 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_553 k007-0256 45.7 µM -0.346560442640089 0.365932156577919 no 2124 0.364460784163791 3067 6287000
SGTC_487 nimodipine 119 µM -0.34671116754814 0.365875487772559 no 2125 0.364404159782937 3067 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1882 5615643 20 µM -0.346857162634416 0.365820600052123 no 2126 0.364349315124177 3082 2253075
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.347522975170257 0.365570318711351 no 2127 0.364099230556398 3018 165521
SGTC_3307 9126885 69.2785 µM -0.34781659034512 0.365459965879717 no 2128 0.363988964702268 3004 24824909
SGTC_1056 3448-1962 115 µM -0.347855419752423 0.365445373002126 no 2129 0.363974383336398 3093 715507
SGTC_3077 9117319 49.47 µM -0.348053471678045 0.36537094410855 no 2130 0.363900013192906 2998 17154678
SGTC_1893 st059353 36.1 µM -0.348820493793617 0.365082741263821 no 2131 0.363612038410676 3082 3112488
SGTC_1438 4092-1045 4 µM -0.349037287595824 0.365001296412324 no 2132 0.363530658173154 3020 1351342
SGTC_194 1486-1323 56.904 µM -0.34965208899953 0.36477036164863 no 2133 0.363299907015059 3073 5178754
SGTC_1153 4055-0057 267 µM -0.350636674831195 0.364400628834015 no 2134 0.362930469372471 3012 882706
SGTC_92 0063-0024 660.874 µM -0.35105907400102 0.364242047650346 no 2135 0.362772015248652 3030 3594437
SGTC_3107 9121808 49.47 µM -0.353386704106144 0.363368603753914 no 2136 0.361899276116101 3033 662681
SGTC_1661 st013063 9.66 µM -0.353941152058902 0.363160651513035 no 2137 0.361691492899654 3031 721395
SGTC_2882 9058044 58.44 µM -0.354272950562964 0.363036225858105 no 2138 0.361567168605136 3109 18076804
SGTC_488 nitrendipine 139 µM -0.357137455410203 0.361962628403552 no 2139 0.360494452788202 3036 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_3280 9140961 49.47 µM -0.357224144665338 0.361930154721974 no 2140 0.360462005971196 3008 4901226
SGTC_1563 conessine 56.1 µM -0.357575212199229 0.361798655449033 no 2141 0.360330615602411 3127 441082 An anti-amoebic, histamine inhibitor.
SGTC_2166 5933061 31.504 µM -0.359225556395655 0.361180705331544 no 2142 0.359713179800124 3486 2877375
SGTC_121 0557-0495 61.343 µM -0.359231588213457 0.361178447458226 no 2143 0.359710923813717 3053 3104427
SGTC_1822 st052468 42 µM -0.359626767561971 0.361030531630271 no 2144 0.359563131721636 3096 2873678
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.360143945791789 0.360836982954505 no 2145 0.359369745318585 3199 688798
SGTC_560 2332-1943 155 µM -0.36060927336053 0.360662869312718 no 2146 0.359195778007356 3037 21177716
SGTC_3317 9138495 8.753 µM -0.361653670774913 0.360272187787152 no 2147 0.358805426037733 3041 17020139
SGTC_736 0958-0254 92.6 µM -0.363641889397088 0.359528851075446 no 2148 0.358062721005957 3149 6812352
SGTC_631 k072-0230 41.5 µM -0.364402528445423 0.359244610744195 no 2149 0.357778723829908 3154 5773147
SGTC_100 0086-0128 49.5915 µM -0.36590735683827 0.358682506701112 no 2150 0.357217103268099 3084 93297
SGTC_1995 st072814 61.1 µM -0.365912099588409 0.358680735607383 no 2151 0.357215333703251 3054 5769371
SGTC_719 2810-4230 27.3 µM -0.36696135366547 0.358288985534186 no 2152 0.356823922656728 3073 721079
SGTC_1591 genipin 88.4 µM -0.367436268662108 0.35811172000971 no 2153 0.356646811098098 3168 442424 A DNA cross-linking agent.
SGTC_2238 6671620 73.2395 µM -0.367442343394212 0.35810945276918 no 2154 0.356644545829054 2974 729941
SGTC_204 PMA1.184 62.41 µM -0.36752084657644 0.358080153886741 no 2155 0.356615272428664 3055 2252213 YGL008C PMA1
SGTC_133 0724-0033 378.92 µM -0.367877443096816 0.357947075798699 no 2156 0.356482310201811 2963 280309
SGTC_136 0097-0015 404.482 µM -0.369327208443146 0.357406216438538 no 2157 0.355941923744091 3146 4861337
SGTC_579 4491-1009 110 µM -0.369949267152557 0.357174234681892 no 2158 0.355710145813888 3196 1271041
SGTC_367 0335-0881 7.1 µM -0.370181566033963 0.357087617962075 no 2159 0.35562360535105 3215 23828853
SGTC_3150 9097574 49.47 µM -0.370428937403308 0.356995389297598 no 2160 0.355531457975644 3227 17217476
SGTC_444 curcumin 90.4 µM -0.372951532139297 0.356055356061757 no 2161 0.354592258650171 3180 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1359 1582-0056 520 nM -0.373036184294152 0.356023825959537 no 2162 0.35456075668842 3153 3661189
SGTC_3093 9117344 49.47 µM -0.373299933448108 0.355925594516715 no 2163 0.354462612987432 3186 24824913
SGTC_426 0988-0037 14.6 µM -0.37388276933161 0.355708555483291 no 2164 0.354245768196386 3248 5383008
SGTC_1487 3970-0795 2.82 µM -0.374619003950614 0.355434460000453 no 2165 0.353971918766865 3159 3765103
SGTC_408 cantharidin 100 µM -0.375428490021212 0.35513317974962 no 2166 0.353670909935775 3084 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_116 0155-0182 31.788 µM -0.37607842958964 0.354891346165133 no 2167 0.353429294946142 3077 771486
SGTC_77 0828-0286 12.516 µM -0.377248475247203 0.354456135642938 no 2168 0.352994479451771 3159 745345
SGTC_1151 3909-8316 15.3 µM -0.377437646960099 0.354385789102444 no 2169 0.352924196960599 3179 800431
SGTC_801 0866-0028 10.1 µM -0.378874238749442 0.353851731622422 no 2170 0.352390627527413 3031 6849771
SGTC_1943 st076331 65.2 µM -0.380455722481187 0.35326414251726 no 2171 0.351803579059687 3187 24208415
SGTC_2293 7624732 200 µM -0.380847534937494 0.353118621352891 no 2172 0.351658192383166 3042 894453
SGTC_2414 st077232 92.9 µM -0.382116337255659 0.352647529117297 no 2173 0.35118753714215 3012 729801
SGTC_843 0310-0051 143 µM -0.382481753537668 0.352511895966075 no 2174 0.351052030266159 3116 2065037
SGTC_696 1560-0013 611 µM -0.382980583652404 0.352326773293138 no 2175 0.350867080274978 3272 1650269
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.383187936828323 0.352249831985729 no 2176 0.350790210850736 3218 5377381
SGTC_1450 4112-4260 37.6 µM -0.383815519177213 0.35201699560246 no 2177 0.350557592400007 3225 1633175
SGTC_2594 a-mangostin 100 µM -0.384100995703039 0.351911100646711 no 2178 0.35045179676129 3210 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_357 1325-0123 420 µM -0.384147156085363 0.351893978945606 no 2179 0.350434691130101 3198 1098503
SGTC_3262 9137218 49.47 µM -0.384457962278153 0.351778703259513 no 2180 0.350319523723607 3053 17650664
SGTC_211 3455-0679 143.504 µM -0.386377634930395 0.351067013394925 no 2181 0.349608505647358 3173 748649
SGTC_224 benfluorex 43.875 µM -0.386778689735966 0.350918394182821 no 2182 0.349460027437351 3195 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_61 0978-8327 98.565 µM -0.387316577949432 0.35071910430737 no 2183 0.34926092702582 3196 6150059 YHR072W ERG7
SGTC_2753 fluvastatin 17.09 µM -0.387373843654056 0.350697889537837 no 2184 0.349239732451261 3147 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.387399465638971 0.350688397715885 no 2185 0.34923024966649 3048 6312947
SGTC_3142 9086498 49.47 µM -0.389006899047343 0.350093100682637 no 2186 0.348635521433671 3162 25236367
SGTC_3217 9129673 49.47 µM -0.389432476469048 0.349935553886201 no 2187 0.348478125836425 3261 17248312
SGTC_677 0929-0063 136 µM -0.391399138327605 0.349207840611855 no 2188 0.347751114569468 3144 1539583
SGTC_2082 5219693 150 µM -0.392243673301663 0.348895511783611 no 2189 0.347439088860821 3074 2834649
SGTC_276 colchicine 750 µM -0.392722735141931 0.34871838896973 no 2190 0.347262138434185 3232 2833 A microtubule depolymerizer.
SGTC_3322 9139058 2.11 µM -0.394344202787271 0.348119131009391 no 2191 0.346663466325355 3261 4908926 YPR165W RHO1
SGTC_307 1501-1223 22.3 µM -0.394350442589602 0.348116825650056 no 2192 0.346661163227603 3178 2830329
SGTC_2239 6685329 187.64 µM -0.394544014633358 0.34804531125003 no 2193 0.346589719013722 3222 805680
SGTC_1353 1498-1206 8.11 µM -0.394888705536365 0.347917979985722 no 2194 0.346462512858189 3144 6756808
SGTC_2813 7971799 71.43 µM -0.396040558320042 0.347492601866094 no 2195 0.346037554015396 3180 2234054
SGTC_1941 st076221 61.8 µM -0.39608746189163 0.347475284486802 no 2196 0.346020253748265 3198 2828568
SGTC_42 0133-0086 60.653 µM -0.396455361826108 0.347339462320185 no 2197 0.345884565911422 3030 162923 Model of phenazepam hydroxylation.
SGTC_806 3966-4455 5.86 µM -0.399333189696365 0.346277696589612 no 2198 0.344823857447693 3113 714982
SGTC_1468 k284-1086 134 µM -0.400299238041995 0.345921546201964 no 2199 0.34446806455058 3140 15996457
SGTC_2063 5246145 200 µM -0.400657039527173 0.34578967107853 no 2200 0.344336322161953 3218 711240
SGTC_139 0099-0334 718.624 µM -0.404398967789518 0.344411629688022 no 2201 0.342959679559943 3113 97690
SGTC_756 0508-1999 28.3 µM -0.404510561889533 0.34437056447235 no 2202 0.342918656357525 3105 6753853
SGTC_1395 3486-0190 4.35 µM -0.404734183097908 0.344288280221346 no 2203 0.342836456347888 3287 6748079
SGTC_1046 2001-0062 216 µM -0.407390206261743 0.343311527501887 no 2204 0.34186070947597 3090 739778
SGTC_2919 7978188 46.38 µM -0.407779978338069 0.343168276624063 no 2205 0.341717607026101 3290 2980291
SGTC_1270 0831-1170 17.3 µM -0.408024875715898 0.343078282306611 no 2206 0.341627706074501 3168 6764716
SGTC_1512 0259-0544 12.2 µM -0.408480467538632 0.342910886168833 no 2207 0.34146048384879 3135 18476
SGTC_2502 avocadyne acetate 18.59 µM -0.409002956534372 0.342718948247251 no 2208 0.341268745728039 3051 3952079
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.409162094299086 0.342660496568227 no 2209 0.341210354978357 3231 6708760
SGTC_2108 5365811 200 µM -0.410942864362086 0.342006672705042 no 2210 0.340557215300369 3225 780283
SGTC_1618 st003135 44.5 µM -0.413001960629781 0.341251249479327 no 2211 0.339802588633254 3198 1270615
SGTC_2512 diallyl trisulfide 49.23 µM -0.414164861812098 0.340824895162881 no 2212 0.339376686757104 3195 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2669 eugenol 100 µM -0.414391103493656 0.340741971802702 no 2213 0.33929385163455 3196 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2726 cimetidine 79.27 µM -0.418845596299594 0.339110858139362 no 2214 0.337664489572952 3159 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2976 9009005 19.48 µM -0.419000304429471 0.339054262176567 no 2215 0.337607954932505 3297 2993148
SGTC_3199 9111318 49.47 µM -0.419429770050679 0.338897172339359 no 2216 0.337451035495868 3207 8548020
SGTC_3101 9120531 49.47 µM -0.420622652468953 0.338460987111823 no 2217 0.337015324893717 3332 24824904
SGTC_2367 9070478 135.38 µM -0.420997169560038 0.338324087155231 no 2218 0.336878574350945 3132 572802
SGTC_2796 7949634 45.45 µM -0.421255461788451 0.338229684167644 no 2219 0.336784274520667 3105 2971588
SGTC_2065 5221596 34.26 µM -0.421303455203419 0.338212144218949 no 2220 0.336766753749709 3256 788581
SGTC_1564 D-Arginine 115 µM -0.421365321238453 0.338189534820995 no 2221 0.3367441690775 3173 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1870 st057514 26.5 µM -0.421719397177558 0.338060146391115 no 2222 0.336614922260089 3109 5393161
SGTC_1152 3909-8331 15.9 µM -0.422148259977218 0.337903454538873 no 2223 0.336458402160109 3171 16001939
SGTC_1827 berberine 7.24 µM -0.427573980088968 0.33592351442999 no 2224 0.334480656568237 3138 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2666 tannic acid 100 µM -0.427925409843735 0.335795427711052 no 2225 0.334352713369072 3251 16134267 A thiamine antagonist.
SGTC_1811 st050069 61.5 µM -0.428001024988145 0.335767870512035 no 2226 0.334325187072276 3252 3877702
SGTC_1379 2144-0755 36.5 µM -0.428506682462102 0.335583611300979 no 2227 0.334141134711307 3335 5392327
SGTC_1773 st048542 73.5835 µM -0.429746699486705 0.335131922321607 no 2228 0.333689954453622 3146 3237138
SGTC_1246 0422-0085 105 µM -0.431010625877964 0.334671769334858 no 2229 0.333230322138843 3303 264295
SGTC_2968 9090663 33.37 µM -0.43173858475565 0.334406856637147 no 2230 0.332965710302493 3173 25236811
SGTC_2506 ethyl hematommate 54.16 µM -0.432826715903228 0.334011026804105 no 2231 0.332570331522543 3222 3940691 An allergen.
SGTC_3064 1327-0027 10 µM -0.433528295670582 0.333755910738189 no 2232 0.332315507123395 3171 16000455 YPR107C YTH1
SGTC_2704 st078022 71.1 µM -0.433869118160246 0.333632004878771 no 2233 0.332191743193211 3324 54697681
SGTC_1048 3161-0300 24.5 µM -0.434959175532377 0.333235836889831 no 2234 0.331796030189676 3239 2165101
SGTC_3133 9127736 49.47 µM -0.435050290239519 0.333202730783426 no 2235 0.331762962186663 3337 27243420
SGTC_209 4077-0173 175.592 µM -0.435457715190932 0.333054710717624 no 2236 0.331615112639252 3228 15993494
SGTC_1689 st020265 53.493 µM -0.436498560021741 0.332676683322159 no 2237 0.331237521879988 3302 5758320 YPR016C TIF6
SGTC_2132 5317594 122.667 µM -0.439407348982877 0.331621134719115 no 2238 0.330183201239654 3131 794577
SGTC_1761 st044296 37 µM -0.440362040651622 0.33127498453239 no 2239 0.329837456556677 3143 1826700
SGTC_2980 9014342 25.29 µM -0.440641481441639 0.331173692703531 no 2240 0.329736283650947 3317 2996599
SGTC_2534 helenine 20.12 µM -0.441184772706061 0.330976795589957 no 2241 0.329539618048139 3163 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1960 st011366 51.8 µM -0.44118731675969 0.330975873695683 no 2242 0.329538697238884 3194 3972846
SGTC_1166 k206-0078 225 µM -0.441399359874265 0.330899038771838 no 2243 0.329461952780169 3178 5404595
SGTC_3140 9094243 49.47 µM -0.442263620871949 0.330585943016833 no 2244 0.329149226372108 3289 19291112
SGTC_2029 5175081 200 µM -0.443107074336901 0.330280499469774 no 2245 0.328844144243056 3194 1380876
SGTC_803 4488-1585 147 µM -0.443272349561363 0.330220660860046 no 2246 0.328784376564837 3282 747204
SGTC_946 3434-1334 87.4 µM -0.443825768509822 0.330020324755633 no 2247 0.328584278238084 3276 4047976
SGTC_1865 st057639 52.2 µM -0.444069779956824 0.329932008775224 no 2248 0.328496067227673 3197 688818
SGTC_20 0481-0013 4.944 µM -0.45020403784669 0.327714939132601 no 2249 0.326281662520316 3256 182045
SGTC_2133 5320837 200 µM -0.453538198794152 0.326512429022165 no 2250 0.325080621854916 3324 2841355
SGTC_1062 mesoridazine 14.2 µM -0.453575683188187 0.326498919982573 no 2251 0.325067129419286 3241 4078 A neuroleptic.
SGTC_876 0720-0963 56.8 µM -0.453673740731135 0.326463581999304 no 2252 0.325031834880049 3365 765861
SGTC_2825 7998094 58.44 µM -0.454177651501256 0.326282007176825 no 2253 0.324850483513961 3214 2987815
SGTC_1342 1486-1464 234 µM -0.454625917361453 0.32612051755295 no 2254 0.324689192953201 3207 3253938
SGTC_670 4204-0025 119 µM -0.454705611851424 0.326091810696884 no 2255 0.324660521515171 3279 719039
SGTC_1200 1643-0193 18.4 µM -0.455304596669363 0.325876082586895 no 2256 0.324445059876131 3307 5403974
SGTC_3024 9090631 49.47 µM -0.456369061604898 0.325492852765789 no 2257 0.324062304773502 3302 25236383
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.456486220622767 0.325450684307491 no 2258 0.324020188655844 3180 15053
SGTC_3105 9121040 49.47 µM -0.456690094107897 0.325377310472493 no 2259 0.323946905944224 3238 41448907
SGTC_173 1273-0061 2.693 µM -0.457182081922875 0.325200272496328 no 2260 0.323770088092847 3279 2847414 YPL266W DIM1
SGTC_652 0437-0092 114 µM -0.459188312025867 0.324478755018286 no 2261 0.323049471541963 3252 3091274
SGTC_2935 9038016 29.96 µM -0.459651924587373 0.324312115666143 no 2262 0.322883041135332 3363 6463195
SGTC_544 k015-0020 52.4 µM -0.460441118428782 0.324028531394344 no 2263 0.322599813195121 3254 3008304
SGTC_647 0140-0236 81 µM -0.460780894409475 0.323906469720208 no 2264 0.322477905186389 3250 990837
SGTC_80 0159-0065 512.242 µM -0.460831482823835 0.323888297875252 no 2265 0.322459756233267 3293 1548079
SGTC_255 tunicamycin 200.472 nM -0.461110943161909 0.323787920599037 no 2266 0.322359505476593 3257 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2358 9037157 4 µM -0.461260804335416 0.323734098359227 no 2267 0.322305751125378 3285 2388925
SGTC_1405 3909-7894 12 µM -0.461530586982897 0.323637215934276 no 2268 0.322208990988931 3300 7104060
SGTC_2541 muurolladie-3-one 83.07 µM -0.461542410725604 0.323632970149256 no 2269 0.322204750565625 3375 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_393 acivicin 6.25 µM -0.461566390239953 0.323624359421517 no 2270 0.322196150712441 3158 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2695 st077686 51.995 µM -0.461926866891794 0.323494928385736 no 2271 0.322066883241412 3249 2876092
SGTC_1021 4476-0760 85.3 µM -0.462117036400334 0.323426655627297 no 2272 0.321998696840261 3211 746768
SGTC_884 0851-0618 334 µM -0.462908148333839 0.323142702343718 no 2273 0.321715103315001 3310 9642473
SGTC_2459 5811157 9.22 µM -0.463829163103132 0.322812252909213 no 2274 0.321385073745247 3295 2870684 YBR192W RIM2
SGTC_1157 4092-0394 27.6 µM -0.463909708814145 0.322783360687336 no 2275 0.321356218294714 3401 3659885
SGTC_2661 dactinomycin 12.96 µM -0.464276513092782 0.322651799357962 no 2276 0.321224824529022 3241 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2274 7947094 46.08 µM -0.466851619098899 0.321728814357239 no 2277 0.320303020841858 3291 2971028
SGTC_2289 7946404 165.07 µM -0.470651728378221 0.320368765009074 no 2278 0.318944730570406 3207 1246120 YPR165W RHO1
SGTC_1068 loratadine 26.9 µM -0.471873844495696 0.319931883870744 no 2279 0.318508419143989 3258 3957 A H1 histamine antagonist.
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.472412343414016 0.319739460879311 no 2280 0.318316247799221 3348 756377
SGTC_1421 4029-0249 71.4 µM -0.472495716608825 0.319709673289139 no 2281 0.318286499203927 3371 2894095
SGTC_2967 9089538 49.85 µM -0.475167410652483 0.318755746532087 no 2282 0.317333826807459 3403 728216
SGTC_3204 9114183 49.47 µM -0.475504728056819 0.318635392722163 no 2283 0.317213632025069 3170 17027248
SGTC_1514 1189-1591 158 µM -0.478985650974341 0.317394529377527 no 2284 0.315974418336605 3395 767698 YMR146C TIF34
SGTC_2948 9070189 9.45 µM -0.480183958886116 0.31696783556852 no 2285 0.315548296036152 3321 6473636 YDL196W YDL196W
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.480826645006829 0.316739087915715 no 2286 0.31531985566059 3217 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2932 9016711 44.54 µM -0.481631963937786 0.316452554174526 no 2287 0.315033707703146 3344 7117328
SGTC_10 0279-0212 42.575 µM -0.481891046997347 0.316360395423011 no 2288 0.31494167324112 3288 39851 YBR002C RER2
SGTC_2051 5263410 176 µM -0.482452772992977 0.316160622354643 no 2289 0.31474216994461 3386 227584
SGTC_818 4072-2707 53.5 µM -0.483449173897511 0.315806392882906 no 2290 0.314388419995574 3199 882871
SGTC_610 4215-0184 155 µM -0.483741788142863 0.315702397998192 no 2291 0.314284566174662 3318 5605015
SGTC_351 caspofungin 25 nM -0.485668448631944 0.315018028900269 no 2292 0.313601128621127 3277 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_633 0437-0093 97.7 µM -0.486018256315715 0.314893841705397 no 2293 0.313477111068398 3285 2831118
SGTC_195 4234-0266 16.654 µM -0.48826130082629 0.314098023650135 no 2294 0.312682384510219 3261 2303354
SGTC_50 0929-0078 56.389 µM -0.488746881647513 0.31392585622869 no 2295 0.312510454224392 3221 1377751
SGTC_764 1951-2361 146 µM -0.489870337197061 0.313527679386597 no 2296 0.312112827178337 3259 5438930
SGTC_1500 4488-1866 171 µM -0.491567642718967 0.312926529765958 no 2297 0.311512511229736 3411 2900003
SGTC_124 0136-0217 7.121 µM -0.492011646599168 0.312769354965252 no 2298 0.311355555116168 3443 3976905
SGTC_1239 0337-0584 35.4 µM -0.492388166127614 0.312636095900812 no 2299 0.311222481696607 3421 914301 YML130C ERO1
SGTC_1419 3993-2473 62.6 µM -0.496110930048736 0.311319843057838 no 2300 0.309908074051087 3327 704026
SGTC_3168 9103419 49.47 µM -0.496821349114315 0.311068934268422 no 2301 0.309657519374579 3317 16649256
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.49686001679811 0.311055279971543 no 2302 0.309643884370141 3357 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2735 sertaconazole 140 nM -0.497696785264539 0.31075986479591 no 2303 0.309348887145043 3353 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_635 k038-0028 24.7 µM -0.498404602720519 0.310510070058564 no 2304 0.309099446638976 3302 4035102
SGTC_2908 7930301 100 µM -0.498762078617677 0.310383946997777 no 2305 0.308973502719 3262 2223178
SGTC_3326 9140064 16.379 µM -0.499304682207754 0.310192550607835 no 2306 0.308782378549898 3245 1868434
SGTC_934 2950-0684 338 µM -0.50025769573208 0.309856511879597 no 2307 0.308446818839528 3421 1121253
SGTC_2033 5192550 145 µM -0.500988904058601 0.309598790746875 no 2308 0.308189466011917 3282 182073
SGTC_493 zm226600 134 µM -0.502544953791312 0.309050658253192 no 2309 0.307642119525674 3430 5240098 A potassium channel opener. YCR052W RSC6
SGTC_3114 9122766 49.47 µM -0.50406748951711 0.308514742549888 no 2310 0.30710697583966 3326 17176985
SGTC_3047 9092122 49.47 µM -0.504218251756923 0.308461698077933 no 2311 0.307054007971202 3327 17173831
SGTC_2430 5571206 200 µM -0.504889139157206 0.308225700275656 no 2312 0.306818351397013 3419 1731771
SGTC_137 0438-0332 85.389 µM -0.505548349666751 0.30799388723751 no 2313 0.30658687419603 3398 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1998 st075797 76.8 µM -0.50742044136506 0.307335979309675 no 2314 0.305929922971037 3401 24208315
SGTC_2769 toremifene 3.73 µM -0.507939296634215 0.307153747900592 no 2315 0.305747957488405 3457 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_795 0685-0265 78 µM -0.507986440135806 0.307137192604389 no 2316 0.305731426371063 3427 302754
SGTC_2664 lyso-paf C-16 73.48 µM -0.509121375614898 0.306738758126058 no 2317 0.305333574811385 3290 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_577 r071-0003 38.6 µM -0.50958354946902 0.306576571101346 no 2318 0.305171625624865 3310 4568517 YMR134W ERG29
SGTC_2434 5670830 169.91 µM -0.51368051859077 0.305140512834126 no 2319 0.303737687284205 3370 1549830
SGTC_471 1-acyl-paf 4 µM -0.51373006964292 0.305123162624196 no 2320 0.303720362841166 3276 16759367
SGTC_2745 rifampicin 24.3 µM -0.513787914038302 0.305102909069417 no 2321 0.303700139369714 3320 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1703 st026983 48.3 µM -0.516478732055018 0.304161410394303 no 2322 0.302760044686788 3424 1104023
SGTC_2592 piperlongumine 83.33 µM -0.51692977938544 0.304003718799502 no 2323 0.30260258931 3312 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_761 k216-0224 480 µM -0.517407332366845 0.303836800243328 no 2324 0.302435921126314 3468 1340404
SGTC_823 0417-1665 178 µM -0.51794722776744 0.303648140465689 no 2325 0.302247544744389 3358 3429856
SGTC_582 0987-0078 156 µM -0.518403330371145 0.303488801806957 no 2326 0.302088445777339 3453 1625765
SGTC_520 3584-0023 682 µM -0.518625595752289 0.303411167315815 no 2327 0.302010928184143 3316 1340790
SGTC_872 0588-0139 234 µM -0.519352145153263 0.303157454716105 no 2328 0.301757598128523 3357 2047100
SGTC_398 bronopol 33.3 µM -0.521504390038028 0.302406443670256 no 2329 0.301007724089804 3279 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2950 9072895 21.46 µM -0.522044560857811 0.302218085843104 no 2330 0.300819652520382 3393 17332245
SGTC_2744 captopril 92.04 µM -0.524104672749636 0.30150020765787 no 2331 0.30010286934632 3368 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1839 st053978 48 µM -0.524631585270344 0.301316720053972 no 2332 0.299919662644978 3418 3788398
SGTC_3178 9107506 49.47 µM -0.524840297876555 0.301244053629419 no 2333 0.299847107580977 3435 8897194
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.525029026357507 0.301178351774332 no 2334 0.299781506469477 3401 4213774
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.525387542799402 0.301053559591773 no 2335 0.299656905783243 3351 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2551 apiole 73.87 µM -0.527146180798488 0.300441751807647 no 2336 0.299046039618017 3314 10659 A possible DNA adduct former.
SGTC_207 4185-0010 4.486 µM -0.527185095974877 0.300428220066641 no 2337 0.299032528755745 3450 3761753
SGTC_1825 st052143 62.6 µM -0.527355039167292 0.30036912996593 no 2338 0.298973529854381 3449 674173
SGTC_375 3970-0961 9.27 µM -0.528284985616951 0.300045875957014 no 2339 0.298650775519235 3335 2898222
SGTC_2425 5628681 7.85 µM -0.529255449229427 0.299708705897381 no 2340 0.298314128023754 3388 5714958
SGTC_172 1112-0046 2.638 µM -0.529395134169936 0.299660189018983 no 2341 0.298265686455388 3294 2802135 YIL048W NEO1
SGTC_380 3970-0968 6 µM -0.529673048623544 0.29956367136025 no 2342 0.298169318702407 3303 2891601
SGTC_2106 5357045 167.29 µM -0.529884446438024 0.29949026387965 no 2343 0.2980960253115 3373 668842
SGTC_2640 pentamidine 10.38 µM -0.529929056603792 0.299474774128216 no 2344 0.298080559642732 3400 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1614 st002383 48.6 µM -0.530499343375246 0.299276788481843 no 2345 0.297882882076441 3426 1947235
SGTC_1572 epiandrosterone 68.9 µM -0.530630628764929 0.299231218729836 no 2346 0.297837383303155 3382 441302 A steroid.
SGTC_1019 4262-0212 3.4 µM -0.531110563109774 0.299064658148492 no 2347 0.297671082373226 3421 4677213
SGTC_1065 prochlorperazine maleate 2.48 µM -0.531376349584612 0.298972435416948 no 2348 0.297579003555933 3436 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1646 st011709 75.6 µM -0.531981739628835 0.298762425088985 no 2349 0.297369321344829 3421 5757843
SGTC_1365 1672-3266 55.4 µM -0.532379557528135 0.298624458234247 no 2350 0.297231570345613 3434 6415873
SGTC_1027 k015-0025 8.67 µM -0.533778479262755 0.298139529729341 no 2351 0.296747402411522 3386 3598955
SGTC_2269 7935389 174.42 µM -0.535280915054185 0.29761911854059 no 2352 0.296227810700504 3382 97605
SGTC_665 3914-0008 307 µM -0.536464924772109 0.297209295575932 no 2353 0.295818635447743 3337 1069549
SGTC_2738 aclarubicin 5.55 µM -0.537132376762956 0.296978383216943 no 2354 0.295588088960593 3328 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_203 k066-0004 30.888 µM -0.537181742638954 0.296961307808985 no 2355 0.29557104063438 3452 6795412
SGTC_1914 st062367 72.6 µM -0.537802269830368 0.296746708895338 no 2356 0.29535678238667 3329 978205
SGTC_2557 derrustone 83.84 µM -0.540487155876945 0.29581900540341 no 2357 0.294430558199301 3439 629853 An antioxidant.
SGTC_458 nppb 133 µM -0.540569527516051 0.295790564764757 no 2358 0.294402163081711 3511 4549 A chloride channel blocker.
SGTC_1222 0366-0074 1.18 µM -0.54309836905886 0.294918037983786 no 2359 0.293531037756182 3463 286520
SGTC_1857 st056007 79.3 µM -0.543165732660864 0.29489481173131 no 2360 0.293507848940105 3442 619834
SGTC_2328 6201408 200 µM -0.545579270239903 0.294063206459172 no 2361 0.292677588519646 3424 2890418
SGTC_2338 7999974 200 µM -0.546062831816536 0.293896721566181 no 2362 0.292511373904961 3452 315925
SGTC_690 glyoxal 20.3 µM -0.546262847577202 0.293827871103237 no 2363 0.29244263531843 3391 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2591 skatole 100 µM -0.54720841119668 0.293502485350151 no 2364 0.292117779096986 3446 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_361 000s-0510 1.45 µM -0.547483764496316 0.293407762623091 no 2365 0.292023210771553 3386 660
SGTC_184 1494-0393 24.714 µM -0.547678271831245 0.293340859794976 no 2366 0.291956417065587 3340 3090647
SGTC_103 0844-0104 51.839 µM -0.548844642515432 0.292939822801141 no 2367 0.29155603536571 3487 5375804
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.548967651247552 0.292897543147736 no 2368 0.291513824915191 3472 5282362
SGTC_3263 9137018 49.47 µM -0.549119197517606 0.292845458676784 no 2369 0.291461825726498 3384 43844957
SGTC_1121 fusaric acid 630.51 nM -0.54964413149142 0.292665078983778 no 2370 0.29128174164835 3328 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2158 5657123 3.6195 µM -0.549870483853594 0.292587314902251 no 2371 0.291204105136785 3414 2858827
SGTC_202 3594-0513 34.79 µM -0.551969097213126 0.291866787105598 no 2372 0.290484762973823 3405 708429
SGTC_2603 homopterocarpin 100 µM -0.552127800169451 0.291812332428817 no 2373 0.290430398168856 3434 101795 A weak amylase inhibitor.
SGTC_1237 0330-0133 46.1 µM -0.552257653921624 0.291767780106432 no 2374 0.290385919403321 3392 X1237 YHR072W ERG7
SGTC_406 estrone 100 µM -0.553755468056695 0.291254115121661 no 2375 0.289873104301629 3478 5870 A steroid.
SGTC_2714 st079313 56.9 µM -0.55391314051805 0.291200067009772 no 2376 0.289819145808799 3423 2939799
SGTC_1688 st021091 57.6 µM -0.555207679267959 0.290756492766551 no 2377 0.289376308467447 3465 3656366
SGTC_572 0960-0087 17.7 µM -0.555231373761287 0.290748376783745 no 2378 0.289368205990769 3387 6796365
SGTC_913 3487-1245 167 µM -0.556518601532865 0.290307626942476 no 2379 0.288928190871291 3357 4016153
SGTC_2953 9074162 66.49 µM -0.556914946461072 0.290171980532778 no 2380 0.288792771076865 3427 16451992
SGTC_2583 asiatic acid 100 µM -0.55824536549037 0.289716870776462 no 2381 0.288338423345937 3496 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2118 5526350 200 µM -0.559105614741553 0.289422775139777 no 2382 0.288044821534 3422 743594
SGTC_298 1391-0729 10 µM -0.561231618641977 0.288696554904249 no 2383 0.287319825422401 3411 3237558
SGTC_1127 asiatic acid 681.4 nM -0.561397102102628 0.288640063537236 no 2384 0.287263429558844 3363 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1144 3486-0183 12.5 µM -0.562223478317174 0.288358040050314 no 2385 0.286981883463941 3413 6744069
SGTC_1625 st003711 30.1 µM -0.567544503616214 0.286545213499824 no 2386 0.285172149755477 3536 24207034 YER133W GLC7
SGTC_2487 5918373 44.05 µM -0.568177402410828 0.286329950729954 no 2387 0.284957257030128 3531 2876279
SGTC_2876 9059903 25.97 µM -0.572816180206224 0.284754548704941 no 2388 0.283384581240986 3470 6916095
SGTC_2129 girgensonine 121.053 µM -0.573634138716698 0.284477186729084 no 2389 0.283107702536323 3425 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3318 9139014 38.6185 µM -0.573822902274727 0.284413197128773 no 2390 0.283043824570805 3457 16643984
SGTC_2779 methotrexate 400 µM -0.573990421925951 0.284356414833127 no 2391 0.282987141380316 3519 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_3020 9089140 49.47 µM -0.575215489136864 0.283941332019666 no 2392 0.282572784292017 3495 17217859
SGTC_2099 5377090 177.372 µM -0.575491567393851 0.28384782998642 no 2393 0.28247944604229 3451 2243829
SGTC_2811 7967822 32.47 µM -0.57742641544689 0.283192950666431 no 2394 0.281825717001381 3484 2232244
SGTC_3306 9127676 59.7925 µM -0.578108249504645 0.282962346205188 no 2395 0.281595518906617 3442 41905287
SGTC_292 k038-0015 474 µM -0.579455581219027 0.282506927722761 no 2396 0.281140904968368 3472 46368540
SGTC_964 1287-0107 19.4 µM -0.582359529503549 0.281526549476065 no 2397 0.280162267752844 3525 51516812 YPR165W RHO1
SGTC_3265 9137266 49.47 µM -0.583735111033881 0.281062724167192 no 2398 0.279699270473575 3449 17224265
SGTC_2528 xanthyletin 44.79 µM -0.588098525654409 0.279593894446598 no 2399 0.278233081341447 3461 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2109 5483026 200 µM -0.588638174998716 0.279412494821113 no 2400 0.278052009771485 3474 759335
SGTC_530 4358-1714 28 µM -0.589794503811099 0.279023994983373 no 2401 0.277664213964018 3498 1564641
SGTC_2866 9034245 58.44 µM -0.590194398386907 0.278889700783029 no 2402 0.277530163585528 3465 6462273
SGTC_506 n9-isopropylolomoucine 153 µM -0.590577261001914 0.278761155799253 no 2403 0.277401852205517 3526 6610355
SGTC_1982 st072467 71.9 µM -0.591171423611018 0.278561724595428 no 2404 0.277202783852623 3390 3163533
SGTC_428 3448-4153 16.5 µM -0.591445022615616 0.278469914221855 no 2405 0.27711114069581 3414 3834874
SGTC_459 nigericin 15.3 µM -0.591658723368208 0.27839821388852 no 2406 0.277039571028707 3545 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_706 4262-0057 46.9 µM -0.592191457296038 0.278219511534083 no 2407 0.276861194632161 3471 883298
SGTC_2399 5884133 200 µM -0.592614573071656 0.278077619786419 no 2408 0.276719561995645 3458 722445
SGTC_919 tnp00227 403.569 nM -0.592794734073093 0.278017213566593 no 2409 0.27665926616449 3475 1269246 A methoxyflavone. YNL221C POP1
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.594343925247692 0.277498049330287 no 2410 0.276141052633997 3627 16725076
SGTC_2085 5307070 144.047 µM -0.594773465346542 0.277354185995882 no 2411 0.27599745336881 3451 2840351
SGTC_2008 4012253 172 µM -0.59499470029908 0.277280103308211 no 2412 0.275923506769636 3473 603940
SGTC_34 0469-0683 81.75 µM -0.59566683959504 0.277055090274786 no 2413 0.275698907521098 3479 3690923
SGTC_887 0885-0007 9.62 µM -0.597365866797569 0.276486703302975 no 2414 0.27513156872915 3529 5719458
SGTC_477 mead ethanolamide 10 µM -0.597762154783808 0.276354212701991 no 2415 0.274999323066445 3416 16061185
SGTC_1693 xanthone 101.9 µM -0.598231069136375 0.276197481232743 no 2416 0.274842881647261 3497 7020 An insecticide.
SGTC_2007 4011539 71.82 µM -0.598473848115967 0.276116351135227 no 2417 0.274761901817101 3523 45595301
SGTC_3245 9134821 49.47 µM -0.599354975094002 0.27582200090495 no 2418 0.274468097500829 3440 17014901
SGTC_2361 9034121 116 µM -0.600836365147579 0.275327473927401 no 2419 0.273974490254532 3473 6496917
SGTC_3129 9127257 49.47 µM -0.601139915099893 0.275226194860002 no 2420 0.27387339994445 3397 837894
SGTC_2180 6301957 200 µM -0.60133955723414 0.275159594507528 no 2421 0.27380692379087 3506 845462
SGTC_3155 9099265 49.47 µM -0.601354838678143 0.27515449696496 no 2422 0.273801835756797 3478 25236499
SGTC_1775 st081588 35.1725 µM -0.603961338718472 0.27428570879466 no 2423 0.272934673141339 3555 1426443 YGL099W LSG1
SGTC_3195 9113082 49.47 µM -0.604630885148664 0.274062757109518 no 2424 0.272712140215321 3512 17018038
SGTC_2683 piperine 63.03 µM -0.609107500361282 0.272574397779134 no 2425 0.271226593209186 3470 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2881 9058953 51.95 µM -0.609428460685562 0.272467841089421 no 2426 0.271120238986845 3485 17122249
SGTC_478 N-arachidonylglycine 10 µM -0.609488125459248 0.272448035062363 no 2427 0.271100470609604 3483 5283389
SGTC_651 3253-0966 34.4 µM -0.610382049633757 0.27215137799033 no 2428 0.270804378082819 3507 781462
SGTC_3183 9108214 49.47 µM -0.612535447622792 0.271437412715426 no 2429 0.270091776283119 3477 4974831
SGTC_1620 st003704 16.5 µM -0.613193974719667 0.271219262629602 no 2430 0.269874044152603 3531 2834414
SGTC_2240 6690706 185.951 µM -0.613796673031421 0.271019683562276 no 2431 0.269674848013989 3457 805876
SGTC_1488 4013-0813 75.9 µM -0.614758633854079 0.270701289239294 no 2432 0.269357065684489 3513 2910057
SGTC_2316 5844804 197.44 µM -0.614971810254926 0.270630756400055 no 2433 0.269286668600554 3557 776813
SGTC_1160 4092-0570 10.5 µM -0.618635686912897 0.269419940311823 no 2434 0.268078193314137 3546 4994975
SGTC_832 4083-0019 164 µM -0.619159280625584 0.269247128225922 no 2435 0.267905716910234 3615 1990758
SGTC_2647 atorvastatin 60.16 µM -0.620375364461703 0.268845974438421 no 2436 0.267505343888804 3532 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_614 0462-0418 107 µM -0.621339006131929 0.268528307920801 no 2437 0.267188297171926 3444 5188303
SGTC_639 0833-0042 114 µM -0.621562498854192 0.268454660035433 no 2438 0.267114793174052 3523 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1623 st003709 20.3 µM -0.622010130067681 0.268307182011275 no 2439 0.266967603499153 3556 16192618
SGTC_2623 humulene 100 µM -0.622129853172137 0.268267744559731 no 2440 0.266928243205108 3507 6187145 An anti-inflammatory.
SGTC_1259 0671-0132 43 µM -0.622220693271602 0.268237823275408 no 2441 0.266898380474246 3478 X1259
SGTC_93 0109-0045 59.227 µM -0.622264764024338 0.268223307675145 no 2442 0.266883893284122 3618 88733
SGTC_3284 9108171 64.8615 µM -0.623340823539007 0.267869008234132 no 2443 0.266530288158033 3500 8687505
SGTC_301 4119-0100 24.5 µM -0.623626997701971 0.26777482326785 no 2444 0.266436288047496 3538 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_58 0957-0393 9 µM -0.62502475293711 0.267315037259677 no 2445 0.265977406163718 3540 6997992
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.626758311183187 0.26674534409305 no 2446 0.265408837179264 3516 803109
SGTC_1441 4106-0040 13 µM -0.62732259984573 0.26656003635915 no 2447 0.265223896055241 3567 2904180
SGTC_1049 3226-0134 66 µM -0.629064635277913 0.26598837732342 no 2448 0.264653370891344 3583 5702385
SGTC_466 geldanamycin 89.2 µM -0.630480337679303 0.265524264237787 no 2449 0.264190181599737 3470 5288382 HSP90 inhibitor.
SGTC_815 1582-0027 36.9 µM -0.631055602771064 0.265335791164801 no 2450 0.264002084502142 3576 3128206
SGTC_3164 9100705 49.47 µM -0.632775252511353 0.264772790577266 no 2451 0.263440209871062 3578 17174235
SGTC_1252 0493-0875 34.8 µM -0.63494969393973 0.264061765160823 no 2452 0.262730612570045 3564 3960963
SGTC_1336 1486-0901 104 µM -0.636010669815558 0.263715187809598 no 2453 0.262384733809983 3529 5006114
SGTC_969 1313-0238 134 µM -0.637541614474092 0.263215500163441 no 2454 0.26188605624284 3568 5212874
SGTC_3216 9129716 49.47 µM -0.63830516123713 0.26296646570986 no 2455 0.261637526457461 3541 8056934
SGTC_1770 st043884 66.3 µM -0.639753289286048 0.26249448283535 no 2456 0.261166502366927 3578 670149
SGTC_115 0527-0192 112.043 µM -0.64028703896508 0.262320629268051 no 2457 0.260993002728092 3591 4233931
SGTC_1172 0370-0043 85 µM -0.641310917650817 0.261987295458057 no 2458 0.260660348664021 3612 376585
SGTC_2433 5607874 27.82 µM -0.642431594735919 0.261622697055451 no 2459 0.260296495495468 3583 2252428
SGTC_325 2810-4341 181 µM -0.642495626743509 0.261601872902621 no 2460 0.26027571396159 3590 774970
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.64306189338411 0.261417751679147 no 2461 0.260091969819923 3612 65057 A dermal irritant. YDR527W RBA50
SGTC_138 0850-0259 40.9225 µM -0.643642208176891 0.261229131777931 no 2462 0.259903736693191 3627 6813004
SGTC_2297 7971671 152.32 µM -0.644047231601143 0.261097528332722 no 2463 0.259772403394846 3615 909016
SGTC_2018 5133068 143 µM -0.644135721556091 0.261068780006885 no 2464 0.259743714113129 3578 785362
SGTC_1032 k061-1018 98.7 µM -0.644338150521335 0.261003021669101 no 2465 0.25967809087408 3669 4005393
SGTC_1302 1159-0335 255 µM -0.644464312199477 0.260962042799691 no 2466 0.259637196224509 3585 649284
SGTC_2384 9036245 200 µM -0.645256394667095 0.260704840255922 no 2467 0.25938052280747 3560 6462766
SGTC_197 4544-0043 41.561 µM -0.646247507785605 0.260383192942751 no 2468 0.259059538471186 3575 896523
SGTC_1936 st074407 74.3 µM -0.646619054959065 0.260262666923724 no 2469 0.258939261243748 3597 809813
SGTC_3060 1327-0027 12.5 µM -0.646998564473008 0.260139587689441 no 2470 0.258816436276507 3513 16000455 YPR107C YTH1
SGTC_1309 pyrazolanthrone 13.4 µM -0.648558666115853 0.259633944417557 no 2471 0.258311839779275 3616 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_691 1548-0686 185 µM -0.651254369177908 0.258761439603325 no 2472 0.257441149451822 3565 46495133
SGTC_2334 9017922 200 µM -0.65159780414246 0.2586503907958 no 2473 0.257330332334286 3599 3163164
SGTC_1744 st037937 38.9 µM -0.651729176251215 0.258607918489303 no 2474 0.257287948685944 3636 1016152
SGTC_3190 9110366 49.47 µM -0.652627617180234 0.258317551389068 no 2475 0.256998188372184 3535 17123768
SGTC_661 1304-0007 33.6 µM -0.655086511909199 0.257523726093869 no 2476 0.25620602787207 3597 3117130
SGTC_1398 3558-0053 112 µM -0.65540328515344 0.257421551782192 no 2477 0.256104068468897 3522 4532369
SGTC_1902 st060212 70.5 µM -0.65672258669834 0.25699624145154 no 2478 0.255679654262426 3638 688944
SGTC_1675 st018485 24.5 µM -0.656876885091004 0.256946523336313 no 2479 0.255630041065666 3575 3323024
SGTC_2531 methyl deoxycholate 70.07 µM -0.657335837098665 0.256798669146234 no 2480 0.255482499088974 3581 16667744 Haematoxylin.
SGTC_3177 9107506 49.47 µM -0.658590102465745 0.25639482590261 no 2481 0.255079510151909 3573 8897194
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.659871915451125 0.255982455181753 no 2482 0.254668014103943 3657 5024745
SGTC_319 1348-1596 45.5 µM -0.659931680148374 0.255963236789622 no 2483 0.254648836533022 3666 5380505
SGTC_362 0310-0100 9.03 µM -0.660101527801442 0.255908623392271 no 2484 0.25459433916626 3627 790235
SGTC_1188 1403-0014 4.57 µM -0.662186786628218 0.255238618039343 no 2485 0.253925760657001 3638 9614867
SGTC_1063 disulfiram 1.84 µM -0.662579077436572 0.25511267538079 no 2486 0.253800086900915 3621 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2200 6600604 21.907 µM -0.663362179862805 0.254861362185934 no 2487 0.253549310947348 3585 2904777
SGTC_1968 st069590 43.6 µM -0.663556827949129 0.254798915843995 no 2488 0.253486998235226 3578 6384066
SGTC_681 1642-0006 26.6 µM -0.664565367422636 0.254475487928211 no 2489 0.253164263294362 3632 4446530
SGTC_2284 7945075 39.21 µM -0.665448408341293 0.254192482797927 no 2490 0.252881865722253 3677 1245402
SGTC_1720 st037298 9.481 µM -0.667125144788906 0.253655561355175 no 2491 0.252346100010937 3612 597396
SGTC_2963 9082507 9 µM -0.667307495184293 0.253597205381381 no 2492 0.252287869891165 3635 16459611
SGTC_2350 9023895 38.85 µM -0.668993199213402 0.253058078632592 no 2493 0.251749908101359 3624 2997209
SGTC_3337 9144342 33.5465 µM -0.669573128973176 0.252872743316551 no 2494 0.251564974199394 3617 17682949
SGTC_1074 carmofur 3.8 µM -0.671142690580408 0.252371497711778 no 2495 0.251064816636303 3666 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2627 acetyl isogambogic acid 100 µM -0.671233886273871 0.252342390119807 no 2496 0.251035772335376 3592 6857789 A caspase activator and apoptosis inducer.
SGTC_938 3126-1755 342 µM -0.67421805707492 0.251390887942834 no 2497 0.25008634561916 3647 1777771
SGTC_502 l-744,832 89.3 µM -0.674924525125401 0.251165908707147 no 2498 0.249861858973428 3604 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1940 st075990 51.1 µM -0.676398468793605 0.250696865065623 no 2499 0.249393844583374 3732 1084979
SGTC_3127 9126946 49.47 µM -0.676718229424206 0.250595170960111 no 2500 0.249292374039206 3582 27243249
SGTC_2401 5128683 200 µM -0.677874986864436 0.250227467702866 no 2501 0.248925480343472 3599 708373
SGTC_198 3454-2873 16.191 µM -0.678216949328959 0.250118821502898 no 2502 0.248817073710717 3632 710957
SGTC_2944 9067346 25.62 µM -0.678223569123059 0.250116718549764 no 2503 0.248814975396279 3587 6473075
SGTC_1520 flindersine 88 µM -0.678960507870752 0.249882669066691 no 2504 0.248581442568884 3707 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_62 0180-0423 3.232 µM -0.679999780280141 0.249552797022359 no 2505 0.248252300015325 3618 30102 YGL099W LSG1
SGTC_2020 4017018 200 µM -0.683374247922436 0.248483315497154 no 2506 0.247185194137887 3672 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1076 itraconazole 331 nM -0.684223475832905 0.248214551983532 no 2507 0.246917030172357 3664 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_3180 9109287 49.47 µM -0.687590178549912 0.247150585713642 no 2508 0.245855447404084 3648 18891271
SGTC_271 rotenone 740 µM -0.688450308680459 0.246879153773514 no 2509 0.245584626098299 3691 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2319 6033012 152.6 µM -0.688830027882916 0.246759376273036 no 2510 0.245465118391466 3627 847246
SGTC_1554 st069299 38.7 µM -0.68905261273622 0.246689179233588 no 2511 0.245395079562599 3647 24207999
SGTC_1440 4100-1550 40 µM -0.689806330437094 0.246451557181153 no 2512 0.245157993584507 3668 742806
SGTC_632 0781-2353 4.65 µM -0.689891680892201 0.246424656762416 no 2513 0.245131153903614 3701 6811515 YHR007C ERG11
SGTC_2746 daunorubicin 9.88 µM -0.690472990412695 0.246241483789783 no 2514 0.244948394786889 3556 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_313 3474-0040 5.03 µM -0.69054483692546 0.246218849734123 no 2515 0.244925811903138 3636 1043375 YIL048W NEO1
SGTC_3244 9134489 49.47 µM -0.690957825682152 0.246088766095496 no 2516 0.244796022503855 3635 16584271
SGTC_2523 spermine 47.74 µM -0.691308611903842 0.245978304038402 no 2517 0.244685810492806 3634 1103 A DNA binding polyamine.
SGTC_358 0075-0058 9.45 µM -0.693469364235354 0.245298473403178 no 2518 0.244007522577407 3662 1069125
SGTC_1106 tegaserod maleate 11.7 µM -0.69490492135055 0.244847367670043 no 2519 0.24355744416646 3693 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2028 5153890 36.43 µM -0.697123984620012 0.244150934456579 no 2520 0.242862602684 3653 2830968 YPR165W RHO1
SGTC_1234 0326-0494 15.5 µM -0.697908969024954 0.243904830111197 no 2521 0.242617062482556 3695 1547813
SGTC_615 k087-0205 167 µM -0.698190387977543 0.243816633670231 no 2522 0.242529068425236 3665 9642773
SGTC_1729 st035615 45.989 µM -0.698846403527495 0.243611105847406 no 2523 0.242324012658322 3689 17385451
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.699247129447467 0.243485605591849 no 2524 0.242198800949557 3681 688761
SGTC_3086 9117350 49.47 µM -0.700160802285922 0.243199590101129 no 2525 0.241913443902833 3599 2679265
SGTC_2994 9053520 71.4286 µM -0.700448437256737 0.24310958666161 no 2526 0.241823647905734 3662 4647384
SGTC_2259 7964009 200 µM -0.701313586428445 0.242838982692086 no 2527 0.241553668333039 3679 313134
SGTC_2852 9023854 51.95 µM -0.701867384240168 0.242665849741685 no 2528 0.241380935425383 3740 19798528
SGTC_1904 st060225 78 µM -0.702344575262721 0.242516719870706 no 2529 0.241232150481176 3653 66595
SGTC_2241 6772625 37.8075 µM -0.702735845097073 0.242394478799176 no 2530 0.241110192383324 3625 2285411
SGTC_963 1269-2853 151 µM -0.703416871545137 0.242181791203942 no 2531 0.24089799764783 3673 3668223
SGTC_2780 5215298 71.43 µM -0.703626142515582 0.242116455273397 no 2532 0.240832813250733 3668 2834131
SGTC_2983 9022671 12.99 µM -0.703929587247584 0.242021734582766 no 2533 0.240738312354812 3670 6405161
SGTC_831 k061-1017 217 µM -0.704100450776132 0.241968408142727 no 2534 0.240685109713072 3734 1240153
SGTC_734 2023-0417 80 µM -0.706660472015529 0.241170190143648 no 2535 0.239888749696268 3651 3935732
SGTC_3297 9117502 71.43 µM -0.707197766755309 0.241002842851762 no 2536 0.239721793099599 3675 7453720
SGTC_3031 9088762 49.47 µM -0.70734828911254 0.24095597207222 no 2537 0.239675031818925 3673 205253
SGTC_1670 st016595 4.04 µM -0.708495148985676 0.240599017098928 no 2538 0.239318911801788 3699 597879
SGTC_3213 9129884 49.47 µM -0.70950162089165 0.240285994580174 no 2539 0.239006622994829 3645 17190742
SGTC_767 0929-0023 86 µM -0.710467049785048 0.239985945463211 no 2540 0.238707278513693 3760 1204563
SGTC_2359 9039622 200 µM -0.712023167047206 0.239502744549489 no 2541 0.238225215095698 3660 6463596
SGTC_3287 9117173 37.0625 µM -0.714038280513964 0.238877807645439 no 2542 0.23760175437757 3678 2789709
SGTC_2351 9026858 72.31 µM -0.715408634629483 0.238453336654189 no 2543 0.237178289286113 3642 1409300
SGTC_3233 9132340 49.47 µM -0.716175743897433 0.238215902842207 no 2544 0.236941419283509 3697 17682950
SGTC_1763 st044482 94.5 µM -0.716276222594852 0.238184812514684 no 2545 0.236910402843831 3719 88505
SGTC_852 0418-0143 439 µM -0.716787339618356 0.238026696046194 no 2546 0.236752662365932 3725 5369229
SGTC_2846 9008642 19.48 µM -0.71915914711749 0.237293719683406 no 2547 0.236021433742323 3708 2992898
SGTC_449 xestospongin c 11.1929 µM -0.719430008122784 0.237210092536899 no 2548 0.23593800649902 3684 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1506 4226-2149 212 µM -0.723324891955578 0.236009356170128 no 2549 0.234740151681342 3740 991114
SGTC_1677 st019204 53.9 µM -0.724068455075011 0.235780507743645 no 2550 0.234511854849677 3716 3945625
SGTC_965 1291-5240 308 µM -0.724083297522733 0.235775940889352 no 2551 0.234507299010734 3685 2834598
SGTC_1064 honokiol 6.76 µM -0.724293410514909 0.235711296716413 no 2552 0.234442810793804 3733 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_3236 9132701 49.47 µM -0.725176761492686 0.235439628505904 no 2553 0.234171798662761 3725 24282524
SGTC_2134 5324836 1.464 µM -0.725585840143127 0.235313877886002 no 2554 0.234046352098562 3697 699272
SGTC_954 1189-0853 2.85 µM -0.72571074492794 0.235275489593335 no 2555 0.23400805667232 3698 2828194
SGTC_2997 9067075 71.4286 µM -0.725746033140796 0.23526464472458 no 2556 0.233997238042686 3741 27209819
SGTC_1051 3253-3903 78 µM -0.725778138602537 0.235254778227266 no 2557 0.23398739541883 3722 5509239
SGTC_2829 7992743 58.44 µM -0.726320390440844 0.235088170498973 no 2558 0.233821191039208 3757 16462845
SGTC_3353 9151644 39.2805 µM -0.72657042890321 0.235011367749899 no 2559 0.233744574363281 3745 4909158
SGTC_1417 3966-0327 90.4 µM -0.727385156256104 0.234761209250507 no 2560 0.233495022535737 3781 651118
SGTC_857 0438-0306 1.35 µM -0.729849146840035 0.234005548216845 no 2561 0.232741199699989 3767 4686136
SGTC_2256 7954252 200 µM -0.730513303722006 0.233802094168811 no 2562 0.232538242009327 3682 2972920
SGTC_432 NS 1619 61.3 µM -0.730672752472905 0.23375326414119 no 2563 0.232489531201136 3772 4552 A K+/calcium channel activator.
SGTC_834 0312-0008 75.7 µM -0.732213670457136 0.233281660537031 no 2564 0.232019080842177 3724 6385573 YIL048W NEO1
SGTC_1315 1237-0019 3.69 µM -0.732573348542056 0.233171655798501 no 2565 0.231909345579646 3713 825140
SGTC_1898 st060199 18.6 µM -0.734925947316591 0.232452842405472 no 2566 0.231192297464139 3737 688866
SGTC_3014 9081533 49.47 µM -0.735593030047305 0.232249246336147 no 2567 0.230989202784453 3736 21367265
SGTC_2307 7538926 6.34 µM -0.736198010319343 0.232064689993253 no 2568 0.230805101475028 3762 96582
SGTC_2322 7413319 38.22 µM -0.737346124773249 0.231714668782192 no 2569 0.230455944651498 3788 1840400
SGTC_2012 4023501 200 µM -0.737674635583817 0.231614571115911 no 2570 0.230356094514632 3742 3477460
SGTC_2365 9042475 200 µM -0.738151603323341 0.231469281339424 no 2571 0.230211164287688 3784 6464479
SGTC_126 0417-1624 672.48 µM -0.740342936373767 0.230802429899613 no 2572 0.229545967146578 3817 41912 YDL195W SEC31
SGTC_379 3970-0972 5.9 µM -0.740963590784216 0.230613751779285 no 2573 0.22935775829606 3741 2898042 YBL034C STU1
SGTC_1305 1181-0477 144 µM -0.742776506291548 0.230063121706885 no 2574 0.228808500762837 3756 6252086
SGTC_796 1234-0020 70.7 µM -0.742786631060953 0.230060048615535 no 2575 0.228805435344417 3689 46495034
SGTC_1633 st005664 67.9 µM -0.744341374574157 0.229588422249957 no 2576 0.228334988217494 3771 2063822
SGTC_2445 5742597 35.57 µM -0.744550627414949 0.22952498746666 no 2577 0.22827171229869 3709 1774255
SGTC_2336 9001819 198.65 µM -0.744766748262663 0.229459480964846 no 2578 0.228206369913053 3776 2989602
SGTC_1149 3909-7961 23.3 µM -0.745481251481 0.229242988730625 no 2579 0.227990420523756 3760 735261
SGTC_575 k072-0246 11.9 µM -0.745804983187828 0.229144936753709 no 2580 0.227892614639343 3773 6796779
SGTC_3160 9100216 49.47 µM -0.745890686896412 0.229118982721699 no 2581 0.227866725771356 3669 17191039
SGTC_3008 9078912 71.4286 µM -0.745938579313997 0.229104479967862 no 2582 0.227852259434678 3738 16648731
SGTC_584 0986-0246 15.4 µM -0.746489086597644 0.228937812656311 no 2583 0.227686010860023 3843 53315 YDR232W HEM1
SGTC_389 tpck 16.7 µM -0.74650371154319 0.228933385849292 no 2584 0.227681595180655 3763 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_581 0958-0271 211 µM -0.746565723805056 0.228914615966657 no 2585 0.22766287248308 3766 4591145
SGTC_1045 1348-1485 165 µM -0.748682604235843 0.228274396374474 no 2586 0.227024265491718 3780 6810614
SGTC_1269 0831-0796 3.05 µM -0.74912003216967 0.228142228265046 no 2587 0.226892431058613 3743 927758
SGTC_1871 st057448 67.3 µM -0.751185973994258 0.227518589278833 no 2588 0.226270370085267 3813 691747
SGTC_125 0133-0007 11.75 µM -0.752027842064702 0.22726473295029 no 2589 0.226017157777521 3832 26541
SGTC_1424 4048-1941 275 µM -0.754455029424787 0.226533734700199 no 2590 0.225288019473615 3837 X1424
SGTC_1132 3456-3614 2.5 µM -0.754747008622542 0.22644588859132 no 2591 0.225200397423889 3844 3125502
SGTC_3017 9080681 49.47 µM -0.755431879273842 0.226239910977739 no 2592 0.224994945632543 3785 16451914
SGTC_2388 9080168 200 µM -0.756451462334704 0.225933463440823 no 2593 0.224689281588893 3737 15943073
SGTC_1120 ficusin 1.78878 µM -0.757179555811451 0.225714770203352 no 2594 0.224471148354716 3874 6199 A DNA cross-linker.
SGTC_994 3910-0338 138 µM -0.757525304980573 0.225610961470567 no 2595 0.224367605696944 3854 3479481
SGTC_1304 1165-0502 251 µM -0.758044917172265 0.22545500242122 no 2596 0.224212046698192 3784 767425
SGTC_2470 5664817 21.68 µM -0.759507650327544 0.225016298116572 no 2597 0.223774469696843 3791 2859561
SGTC_1455 4262-0120 131 µM -0.760736343962888 0.224648161321265 no 2598 0.223407281133077 3881 1529587
SGTC_552 k242-0005 476 µM -0.7610137820979 0.224565083603105 no 2599 0.22332441768856 3815 4088318
SGTC_578 3460-0051 92 µM -0.761752662027101 0.224343914068139 no 2600 0.223103819105835 3845 2876744
SGTC_220 paclitaxel 373.376 µM -0.762488068943517 0.22412390694354 no 2601 0.222884380672901 3704 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_927 2425-1185 123 µM -0.764871164071609 0.223411813711679 no 2602 0.222174133183722 3754 730375
SGTC_2294 7971431 200 µM -0.765832864607676 0.223124812703906 no 2603 0.221887878273871 3738 5741572
SGTC_2323 6148992 148.28 µM -0.766422138622234 0.2229490589914 no 2604 0.2217125820796 3771 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_191 3914-0123 66.505 µM -0.769764910885849 0.221953555348006 no 2605 0.220719678851472 3734 3144412
SGTC_1354 1498-1681 81 µM -0.770576569914389 0.221712220492595 no 2606 0.220478976694179 3844 5754243
SGTC_2831 7999036 19.48 µM -0.771245930981387 0.221513308693365 no 2607 0.220280587047933 3839 2988270
SGTC_2914 7968218 45.32 µM -0.772123788702203 0.221252593324565 no 2608 0.220020556992105 3780 2977111
SGTC_2750 bromebric acid 70.15 µM -0.772428038604415 0.221162274979963 no 2609 0.219930476301378 3861 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1179 1021-1431 9.29 µM -0.772667675246908 0.221091152307763 no 2610 0.219859540862152 3810 2840958
SGTC_2879 9041815 71.43 µM -0.772733873506329 0.221071507381455 no 2611 0.219839947665562 3775 4942971
SGTC_2580 diallyl disulphide 81.36 µM -0.772875339243744 0.221029529505313 no 2612 0.219798080347 3803 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1292 0kpi-0043 232 µM -0.773813416508249 0.220751284325307 no 2613 0.219520568671599 3814 3333905
SGTC_1801 st050089 28.441 µM -0.775019476708872 0.220393847046888 no 2614 0.21916407541654 3814 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1674 st016616 23.6 µM -0.776139324718537 0.220062257495501 no 2615 0.218833363388099 3786 625830
SGTC_2988 9073640 71.4286 µM -0.777089080412725 0.219781257092711 no 2616 0.21855310796027 3825 9102229
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.777602039150599 0.219629575757038 no 2617 0.21840182926318 3855 5282309
SGTC_574 1315-0397 40 µM -0.777902675739044 0.219540705795949 no 2618 0.218313195373322 3816 6794277
SGTC_2258 7960471 200 µM -0.77850270362804 0.219363395753256 no 2619 0.218136356697036 3801 2974708
SGTC_2186 6124449 200 µM -0.778677959543829 0.219311622635765 no 2620 0.218084721306747 3767 3834182 YLR033W RSC58
SGTC_1081 sertraline 6 µM -0.779065659508699 0.219197115445801 no 2621 0.217970518877306 3808 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1824 st053723 68.6 µM -0.779318315367619 0.219122512035045 no 2622 0.21789611413277 3778 675225
SGTC_1018 4259-0013 28.1 µM -0.781095540662933 0.218598151351611 no 2623 0.2173731522423 3888 6801262
SGTC_2360 9040895 200 µM -0.781650669431063 0.21843451180191 no 2624 0.21720995009521 3838 4914414
SGTC_752 1896-0090 130 µM -0.7824530440143 0.218198114439744 no 2625 0.216974185350524 3782 772567
SGTC_1406 3909-7906 11.9 µM -0.783761473368488 0.217812938506884 no 2626 0.216590042042674 3823 X1406
SGTC_735 3076-0345 636 µM -0.783950413432064 0.217757350682038 no 2627 0.21653460343519 3848 2888990
SGTC_2754 granisetron 64.02 µM -0.785378096711304 0.217337578372502 no 2628 0.216115959499725 3785 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_513 4245-1575 41.7 µM -0.787040236823692 0.216849459453149 no 2629 0.21562915613587 3761 719745
SGTC_550 4123-0385 25.7 µM -0.788306953306394 0.216477890105798 no 2630 0.215258590723796 3833 5731123
SGTC_1746 st038117 42 µM -0.788451513667038 0.216435509261055 no 2631 0.215216324524331 3880 2898218
SGTC_2049 5262831 67.185 µM -0.788787136998561 0.216337132891307 no 2632 0.215118214382984 3867 763417
SGTC_365 0121-0052 13.6 µM -0.7890659036634 0.216255441767675 no 2633 0.215036744449042 3858 3101739
SGTC_2025 5147754 141 µM -0.789088748089647 0.216248748119021 no 2634 0.215030068928979 3809 315777 YLR208W SEC13
SGTC_2674 ligustilide 100 µM -0.790507441350988 0.215833291696139 no 2635 0.214615739073705 3843 5319022 A signalling regulator.
SGTC_2977 9011197 71.43 µM -0.79284707140368 0.215149155494862 no 2636 0.21393346391073 3886 2704722
SGTC_45 0kpi-0036 14.9 µM -0.797644115877554 0.213750384816451 no 2637 0.212538521222242 3824 2795021
SGTC_1162 k048-0130 20.1 µM -0.798872013551088 0.213393195265723 no 2638 0.212182314140309 3800 6797406
SGTC_1574 spiramycin 23.7 µM -0.798945020118773 0.213371968969315 no 2639 0.212161146291541 3809 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2537 larixol 68.93 µM -0.801330017636897 0.212679219968679 no 2640 0.211470308729378 3828 6708759
SGTC_1184 1269-1718 139 µM -0.801687921348889 0.212575376308639 no 2641 0.211366752251888 3896 5403821
SGTC_2617 dihydrotanshinone i 20.83 µM -0.803657542936367 0.212004432324174 no 2642 0.210797390290696 3846 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_971 1315-0384 26.7 µM -0.80369621732042 0.211993230573766 no 2643 0.210786219630977 3864 6769120
SGTC_1590 st077108 57.8 µM -0.804644344243047 0.211718720880773 no 2644 0.210512472469721 3800 5489485
SGTC_420 mitomycin C 81.9 mM -0.804857140334771 0.211657138960599 no 2645 0.210451061776366 3823 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3261 9137475 49.47 µM -0.805302820686835 0.211528195703574 no 2646 0.210322477238271 3738 17027690
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.805490593559558 0.211473883443828 no 2647 0.210268316154063 3893 5393153
SGTC_1755 st041960 45.185 µM -0.805562220557328 0.211453167884639 no 2648 0.210247658268021 3888 2257073
SGTC_1482 3346-2049 8.48 µM -0.805789871658165 0.211387335799054 no 2649 0.210182009507673 3851 3826804
SGTC_2458 5808907 16.39 µM -0.805959121752841 0.211338399881957 no 2650 0.210133209909174 3931 2731747
SGTC_680 0417-1641 114 µM -0.807270400864886 0.210959489740543 no 2651 0.209755356574659 3812 2835990
SGTC_1651 st011928 86.1 µM -0.810586006756228 0.210003183479679 no 2652 0.208801727726605 3854 720198
SGTC_1159 4092-0538 61.2 µM -0.810836605414418 0.20993100805043 no 2653 0.208729754964521 3878 717301
SGTC_3175 9106517 49.47 µM -0.812359369065598 0.20949274733325 no 2654 0.208292726669265 3885 41468073
SGTC_922 1866-0035 480 µM -0.812729731857279 0.209386236083945 no 2655 0.208186515403385 3812 3156169
SGTC_1183 1254-0324 198 µM -0.817306596162176 0.20807262504286 no 2656 0.20687661909002 3932 5799357
SGTC_3061 glucosamine 200 µM -0.817453381532714 0.208030576667984 no 2657 0.206834690082168 3751 91431 and experimental redox chemotherapeutic
SGTC_2878 9043973 25.97 µM -0.817559480279861 0.208000186572539 no 2658 0.206804386275972 3944 6465167
SGTC_350 k064-0020 19.8 µM -0.817736500348081 0.207949488163163 no 2659 0.206753831852209 3817 2790705
SGTC_3295 9122362 53.5725 µM -0.818352214194674 0.207773205029122 no 2660 0.206578049692905 3908 4730473
SGTC_2124 5246320 200 µM -0.818703776868605 0.207672589803899 no 2661 0.206477720628779 3877 579342
SGTC_1587 estradiol valerate 56.1 µM -0.820482981914074 0.207163833148604 no 2662 0.205970413442817 3890 13791 A steroid.
SGTC_830 4076-0286 57.8 µM -0.821933854057208 0.206749508208959 no 2663 0.205557272030123 3920 6866659
SGTC_1098 clofazimine 15.1 µM -0.822284269780453 0.206649513744427 no 2664 0.205457563618711 3939 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1879 gemcitabine 100 µM -0.823117727066776 0.206411793869592 no 2665 0.205220524438279 3857 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1037 k284-1091 78.7 µM -0.82327452531596 0.206367089765317 no 2666 0.205175948443641 3827 3334711
SGTC_332 4112-0506 40.9 µM -0.823800181582356 0.206217263931224 no 2667 0.205026552205887 3842 2790355
SGTC_2532 xanthone 78.9 µM -0.823895556683704 0.206190086436545 no 2668 0.204999452676467 3837 7020 An insecticide.
SGTC_2873 9040596 71.43 µM -0.826381989238735 0.20548231762454 no 2669 0.204293718503823 3824 6463863
SGTC_928 2764-0428 58.7 µM -0.826463513114463 0.205459136115217 no 2670 0.204270603772914 3922 662578
SGTC_2418 pentamidine 31.67 µM -0.827520678938788 0.205158669147348 no 2671 0.20397100314597 3847 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.827982023940477 0.205027627857319 no 2672 0.203840340150614 3844 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1832 st054113 55 µM -0.829339819357669 0.204642245927334 no 2673 0.203456072380383 3853 1251267
SGTC_72 0744-0168 198.391 µM -0.830787325641364 0.204231876420884 no 2674 0.203046891944227 3792 677577
SGTC_920 mycophenolic acid 780.421 nM -0.83643072129389 0.202636653844678 no 2675 0.20145631786001 3919 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3063 1327-0034 4 µM -0.837802723877905 0.20224995719112 no 2676 0.201070754348133 3780 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_591 4299-0174 154 µM -0.840033275847046 0.201622222843291 no 2677 0.200444864713057 3874 5509088
SGTC_2396 5342950 42.78 µM -0.840851561112619 0.201392229386065 no 2678 0.200215548764555 3899 1886677
SGTC_3094 9117742 49.47 µM -0.84131174608518 0.201262955420473 no 2679 0.200086655995232 3834 17149698
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.843129362777495 0.200752841780277 no 2680 0.199578049253777 3892 3256 An antibiotic and ribosome inhibitor.
SGTC_861 0443-0273 110 µM -0.844074745685073 0.200487827384632 no 2681 0.199313819426648 3924 6149169
SGTC_2646 retinol 96.75 µM -0.845191161332439 0.200175138963398 no 2682 0.199002058212253 3877 445354 A vitamin A analog and teratogen.
SGTC_2485 5633444 17.78 µM -0.845816370457859 0.200000156966526 no 2683 0.198827595794479 3921 5724239
SGTC_2115 tiliquinol 12.7705 µM -0.846347570410018 0.199851558313466 no 2684 0.198679438779827 3894 71208 A bioactive hydroxyquinoline.
SGTC_3230 9131665 49.47 µM -0.847867275707731 0.199426800610608 no 2685 0.198255945494626 3820 15943720
SGTC_376 3970-0862 59.1 µM -0.850490762101832 0.198694816213731 no 2686 0.197526147131794 3938 3135186
SGTC_1333 1482-0047 286 µM -0.854869373240751 0.197476745202091 no 2687 0.196311733706851 3889 3811116
SGTC_2946 9065502 71.43 µM -0.855061203403557 0.197423484058965 no 2688 0.196258633062858 3755 16489101
SGTC_3174 9107204 49.47 µM -0.856746665909711 0.196955893362608 no 2689 0.195792453470155 3960 3938802
SGTC_951 1171-0579 82.7 µM -0.857746498638923 0.196678831096696 no 2690 0.195516229064716 3876 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_3096 9117468 49.47 µM -0.858566823214119 0.196451688488614 no 2691 0.195289774321126 3848 41316311
SGTC_2480 5767542 37.17 µM -0.86186677303178 0.195539560788263 no 2692 0.194380417627447 3894 2867358
SGTC_945 3381-0768 11.3 µM -0.862182778136646 0.195452350043832 no 2693 0.194293472562923 3977 1126236 YIL048W NEO1
SGTC_312 4092-0653 6.84 µM -0.863383482488582 0.195121196439781 no 2694 0.193963328963362 3890 1148278
SGTC_1006 4099-6547 255 µM -0.864118719696089 0.194918586871906 no 2695 0.193761338263268 3964 3146833
SGTC_142 0335-0849 62.6745 µM -0.869828658909143 0.193349455670283 no 2696 0.192197023592 3934 3889043 YPR107C YTH1
SGTC_140 0062-0056 502.533 µM -0.8700256377051 0.193295462417718 no 2697 0.192143196821684 3868 3758964
SGTC_1727 st034309 9.9045 µM -0.870494473098156 0.193166988407022 no 2698 0.192015119146774 4047 870305
SGTC_1856 st057054 55.7 µM -0.872145213947846 0.192715054264329 no 2699 0.191564581441281 3946 1266018
SGTC_16 erodoxin 22.806 µM -0.872713900235561 0.192559511041501 no 2700 0.191409519642399 3935 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_40 0327-0103 19.753 µM -0.8733820626356 0.192376857863592 no 2701 0.191227432326221 3826 409036
SGTC_2095 5432005 200 µM -0.87350762615743 0.19234254483975 no 2702 0.191193225668371 3942 783734
SGTC_1952 st077036 64.1 µM -0.874060698733974 0.192191450017863 no 2703 0.191042599461459 3930 2937007
SGTC_1325 1431-0015 227 µM -0.87585001880304 0.19170312033257 no 2704 0.190555786993632 3913 1103340
SGTC_2237 6667747 47.222 µM -0.877361016273145 0.191291340973519 no 2705 0.1901452902008 3935 729940 YDL015C TSC13
SGTC_794 k038-0031 316 µM -0.880125329645137 0.19053941056289 no 2706 0.189395709363291 3932 6624242
SGTC_2684 capsaicin 100 µM -0.880434456233117 0.190455436931631 no 2707 0.189311998732189 3980 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2996 9066192 71.4286 µM -0.883928969424865 0.189507740498782 no 2708 0.188367278885841 4014 6472854
SGTC_3237 9133362 49.47 µM -0.88417225078655 0.189441871889738 no 2709 0.188301617739794 3885 43845137
SGTC_1361 1608-0041 5.61 µM -0.884347069826311 0.189394548206232 no 2710 0.188254443155769 3908 X1361
SGTC_2832 7992762 51.95 µM -0.884660754299282 0.18930965175825 no 2711 0.188169814282649 3914 2985177
SGTC_2692 st077426 47.7 µM -0.885269887332227 0.189144861208083 no 2712 0.188005543473269 3961 25238571
SGTC_1944 st076371 56.9 µM -0.885385282168984 0.189113653058925 no 2713 0.187974433806127 3941 24208455
SGTC_3314 9135860 59.4275 µM -0.886287846130531 0.18886966705816 no 2714 0.187731218323664 3927 25252478
SGTC_798 1287-0182 476 µM -0.887150988304061 0.188636519296473 no 2715 0.187498807820426 3967 1649755
SGTC_1384 3089-0840 101 µM -0.887898405739634 0.188434773944913 no 2716 0.187297701190805 3925 1069836
SGTC_147 4466-0538 29.23 µM -0.889552812341606 0.187988684632995 no 2717 0.186853026708698 4017 6742687 YHR072W ERG7
SGTC_3029 9088683 49.47 µM -0.889787727719763 0.187925395644489 no 2718 0.186789938730726 3973 25236615
SGTC_998 3996-0085 177 µM -0.8902099220905 0.187811684547713 no 2719 0.186676588964648 3985 715391
SGTC_2234 tolnaftate 200 µM -0.890698399463245 0.187680174252596 no 2720 0.186545496841124 3947 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_3048 9093155 49.47 µM -0.891549888571994 0.187451068192111 no 2721 0.186317120006075 3881 25236002
SGTC_573 3702-0553 84.7 µM -0.891952822191271 0.187342713068744 no 2722 0.186209110087946 3912 1222756
SGTC_481 bay k-8644 50 µM -0.892149310042467 0.187289888474205 no 2723 0.186156453860186 3925 2303 A calcium channel antagonist.
SGTC_2424 5537928 59.2 µM -0.893125946654225 0.187027462176624 no 2724 0.185894864713408 3995 5382802
SGTC_2179 6298986 200 µM -0.895880947548407 0.186288408763778 no 2725 0.185158175404604 3916 738374
SGTC_1093 fluphenazine 7.97 µM -0.896341240297359 0.186165107806742 no 2726 0.185035269800238 3973 6602611 An atypical antipsychotic.
SGTC_1350 1495-0454 146 µM -0.897906832158674 0.185746103482399 no 2727 0.184617610973072 4009 1069057
SGTC_3165 9101544 49.47 µM -0.899376551035486 0.185353290766638 no 2728 0.184226062459174 3975 5002184
SGTC_208 k072-0098 12.366 µM -0.899549229178095 0.185307172848991 no 2729 0.184180093142937 3957 5948901
SGTC_1425 4048-4433 7.33 µM -0.899734793915136 0.185257621194253 no 2730 0.184130701195678 4014 23734946
SGTC_3104 9120930 49.47 µM -0.899774948982042 0.185246899604164 no 2731 0.18412001416752 3995 17014836
SGTC_91 0417-1751 58.384 µM -0.900975745122719 0.184926459503878 no 2732 0.183800607970077 4073 6795624
SGTC_1431 4049-0260 9.09 µM -0.903848131550741 0.184161343405633 no 2733 0.183037967876406 3953 3854841
SGTC_97 0535-0701 19.132 µM -0.905033012875924 0.183846302037963 no 2734 0.182723949036802 3893 2832013 YGL099W LSG1
SGTC_324 1315-0088 19.6 µM -0.905355960334474 0.183760493618977 no 2735 0.182638419431258 3938 6787421
SGTC_902 1120-0002 2.07 µM -0.905359386514851 0.18375958340305 no 2736 0.182637512173556 3958 3280475
SGTC_596 1155-0152 116 µM -0.905672912648477 0.183676302397016 no 2737 0.182554501895268 3963 280313
SGTC_2671 danthron 100 µM -0.906479106416128 0.183462263569238 no 2738 0.182341159425341 3965 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1109 tnp00067 928.257 nM -0.907451559240591 0.183204291091419 no 2739 0.182084027323676 3970 676295
SGTC_3075 9116269 49.47 µM -0.908760999882463 0.182857280040534 no 2740 0.181738148573422 4009 17015205 YNL244C SUI1
SGTC_2798 7813637 45.45 µM -0.908915387910791 0.182816393171964 no 2741 0.18169739526058 4000 956368
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.909028791379671 0.182786363956131 no 2742 0.181667464153282 3978 5106787 A p450 inhibitor.
SGTC_2742 clothiapine 36.27 µM -0.909805383190888 0.182580805350748 no 2743 0.181462577561352 3928 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2670 beta-carotene 100 µM -0.910046635429778 0.182516976915069 no 2744 0.181398957947563 3912 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_3080 9117754 49.47 µM -0.910401142131087 0.182423209881479 no 2745 0.181305497815399 3995 9550191
SGTC_1901 st060216 58.6 µM -0.910813937011714 0.182314063553433 no 2746 0.181196708923518 3963 688792
SGTC_467 ro 31-8220 72.8 µM -0.912279674371227 0.18192684044348 no 2747 0.180810755624911 3918 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2287 7945887 168.79 µM -0.913307390153072 0.181655642233529 no 2748 0.180540448348098 4002 1245853
SGTC_3356 9151811 4.48 µM -0.914562638760884 0.181324745025792 no 2749 0.180210639982169 3976 1859254 YPR165W RHO1
SGTC_262 fenpropimorph 62.5 µM -0.914644838934658 0.181303089339656 no 2750 0.18018905562422 3953 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2147 5545932 89.7195 µM -0.915439640923961 0.181093781814328 no 2751 0.179980437937718 4018 797404
SGTC_2851 9015922 71.43 µM -0.916513987290114 0.180811098251987 no 2752 0.179698687298626 4005 2996893
SGTC_300 r073-0011 5.04 µM -0.917215108858911 0.180626767377843 no 2753 0.179514965535221 3981 2735780
SGTC_583 1488-1091 88.9 µM -0.91827682430732 0.180347857709971 no 2754 0.179236978672453 4106 4303273
SGTC_1401 3807-4679 7.6 µM -0.918740419677311 0.180226157311742 no 2755 0.179115681373841 3929 3291456
SGTC_1511 0906-3109 28.5 µM -0.918877744879617 0.180190117384668 no 2756 0.179079760870569 4006 2882180
SGTC_119 0121-0043 24.815 µM -0.919291399119993 0.180081584396886 no 2757 0.178971587665065 4007 1092378
SGTC_3207 9114163 49.47 µM -0.919716513110365 0.179970087416728 no 2758 0.178860460514248 4036 849233
SGTC_3313 9133968 57.047 µM -0.919863621849389 0.179931514498283 no 2759 0.178822015592344 3972 1494643
SGTC_518 1021-0119 62.6 µM -0.920055788587905 0.179881134885403 no 2760 0.178771803194668 3967 1097762
SGTC_905 2-aminofluorene 215 µM -0.920474543069637 0.179771382329398 no 2761 0.17866241507774 3983 1539 An established DNA mutagen. YPR165W RHO1
SGTC_961 1252-1571 372 µM -0.921742992042971 0.179439187704537 no 2762 0.178331324850513 4006 6813498
SGTC_1094 duloxetine 25.4 µM -0.923201001862755 0.179057825961489 no 2763 0.177951233428258 3990 60834 A selective serotonin reuptake inhibitor.
SGTC_2928 9011484 9.79 µM -0.923681720247507 0.17893219957728 no 2764 0.177826026084685 4034 2994751
SGTC_2046 4110841 106 µM -0.923906710324059 0.178873421864291 no 2765 0.1777674445296 4004 44119630 YMR134W ERG29
SGTC_3333 9141820 12.094 µM -0.92393302685999 0.178866547573696 no 2766 0.177760593184559 3984 1939433
SGTC_2236 dapsone 200 µM -0.924833057057024 0.17863154571117 no 2767 0.177526376246225 3997 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1706 st031321 9.9705 µM -0.927495626805119 0.177937476015279 no 2768 0.176834630660871 4021 6103185
SGTC_2182 6325192 200 µM -0.928265711797605 0.177737050355271 no 2769 0.176634877764657 3918 736248
SGTC_674 0498-0004 451 µM -0.928702018426232 0.177623558532352 no 2770 0.176521767221942 4000 4231473
SGTC_1308 1187-1617 41.4 µM -0.929496852688888 0.177416924281038 no 2771 0.176315827770428 4012 2882570
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.93008487915129 0.177264151868944 no 2772 0.17616356955144 4096 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2149 5554786 194.827 µM -0.930187435318837 0.177237515740027 no 2773 0.17613702311665 4026 745063 YPR165W RHO1
SGTC_2383 9036125 200 µM -0.930324022796994 0.177202044844382 no 2774 0.176101671685349 3915 79580
SGTC_278 4092-0821 23.9 µM -0.932629065305453 0.176604116444201 no 2775 0.175505760547402 4012 877900
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.932860917059023 0.176544044762897 no 2776 0.175445891895272 3988 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1038 k292-0204 154 µM -0.933493198127406 0.176380289445826 no 2777 0.17528269037172 3970 4454212
SGTC_1284 0929-0043 16 µM -0.933715490362719 0.176322740522466 no 2778 0.175225336186242 3975 1239883
SGTC_258 haloperidol 50.781 µM -0.934595020482691 0.176095156730937 no 2779 0.174998523103925 4036 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1830 st055982 50.3 µM -0.935206151938371 0.175937132278233 no 2780 0.174841034358794 3914 455313 An antimicrobial agent.
SGTC_151 3013-0144 2.285 µM -0.936988505662824 0.175476769912157 no 2781 0.174382235254566 3933 906558 YHR107C CDC12
SGTC_710 3448-4187 58 µM -0.938874926441746 0.174990360686517 no 2782 0.173897481983612 3995 3946412
SGTC_1949 st076024 69.1 µM -0.940422818487739 0.174591879923156 no 2783 0.173500361084008 3941 2921930
SGTC_3042 9091578 49.47 µM -0.941966976378868 0.174194935067669 no 2784 0.173104773772801 3990 25236497
SGTC_3021 9087658 49.47 µM -0.943756458287601 0.173735644721139 no 2785 0.172647057837334 3995 25237042
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.944636972333532 0.17350993408264 no 2786 0.172422122353017 4060 6708561
SGTC_66 0109-0187 42.4 µM -0.945491450522977 0.173291075976667 no 2787 0.172204016772561 3940 759417
SGTC_3073 9114972 49.47 µM -0.945560721598621 0.173273341232389 no 2788 0.172186343046786 4024 41905075
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.947755597295931 0.172712008817088 no 2789 0.171626944991403 3982 6708514
SGTC_187 1488-2104 32.728 µM -0.947820778867906 0.172695356582649 no 2790 0.171610350230578 4035 2852859
SGTC_2971 9092186 9.93 µM -0.948160149184631 0.172608672633068 no 2791 0.171523965546088 4054 25236400
SGTC_13 0199-0087 65 µM -0.948973362860893 0.172401069753925 no 2792 0.171317079959602 4076 4589825
SGTC_3119 9125183 49.47 µM -0.952575951415569 0.171483292453603 no 2793 0.170402483354284 3845 22695334
SGTC_744 1594-0068 283 µM -0.953730159336327 0.171189913901875 no 2794 0.170110124882322 4016 668392
SGTC_3081 9117243 49.47 µM -0.955020961042743 0.170862196120822 no 2795 0.169783548492269 4026 45595589
SGTC_501 nsc-95397 161 µM -0.955990280672496 0.170616362560023 no 2796 0.16953857245948 4101 262093
SGTC_2760 etidronate 98.04 µM -0.957358427595507 0.170269766159832 no 2797 0.16919318700852 4000 3305 A chelator and antioxidant.
SGTC_1146 3579-1023 7 µM -0.960130402330375 0.169568918084873 no 2798 0.168494794512334 4083 X1146
SGTC_2461 5755302 26.15 µM -0.960386420042022 0.169504281722824 no 2799 0.168430385086475 4097 2788904
SGTC_2605 digitonin 300 nM -0.961042938738851 0.1693386038088 no 2800 0.168265289223866 4091 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_157 1348-1695 65.819 µM -0.961073072794013 0.169331001726939 no 2801 0.168257713861748 3999 5380510
SGTC_2736 butenafine 14.65 µM -0.961135264987129 0.169315312856994 no 2802 0.168242080138397 3987 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_630 4356-0227 183 µM -0.961255200879962 0.16928505994798 no 2803 0.168211933581954 4016 779312
SGTC_2688 kanamycin b 96.69 µM -0.961257072408653 0.169284587896721 no 2804 0.168211463190305 4122 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2034 5197015 53.07 µM -0.961604321433291 0.169197016719174 no 2805 0.168124199963454 4054 780676
SGTC_3126 9127922 49.47 µM -0.965471267406689 0.16822379484224 no 2806 0.167154410304187 4112 45595682
SGTC_2781 5567276 71.43 µM -0.965503299321906 0.1682157482101 no 2807 0.167146392124888 4097 2853274
SGTC_1660 st012960 28.1 µM -0.965688949328667 0.168169116558499 no 2808 0.167099925386829 4045 24207266
SGTC_669 0108-0021 26.2 µM -0.971686723503001 0.1666670687581 no 2809 0.16560321183102 3971 17201
SGTC_1190 1486-1332 13 µM -0.973210223251319 0.166286915447468 no 2810 0.165224415423251 4056 4150046
SGTC_2227 7312221 64.1025 µM -0.974073334686006 0.166071795105013 no 2811 0.165010064153698 4124 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2083 5306046 65.942 µM -0.975097158898783 0.165816852251019 no 2812 0.164756033895516 4075 539837
SGTC_3304 9125678 46.087 µM -0.97603188504365 0.165584316788943 no 2813 0.164524331912495 3999 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_769 0302-0231 76 µM -0.976153223843768 0.165554146336308 no 2814 0.164494269676583 3989 571869 YER009W NTF2
SGTC_3116 9124943 49.47 µM -0.977682786196854 0.165174131130556 no 2815 0.164115619032024 4046 41905195 YPL160W CDC60
SGTC_221 trifluoperazine 10.304 µM -0.978191161459992 0.165047951924518 no 2816 0.163989893528656 4038 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_3264 9137442 49.47 µM -0.979599281285597 0.164698781204321 no 2817 0.163641979928811 4078 17015726
SGTC_2761 levamisole 97.89 µM -0.982529048325317 0.163973823399747 no 2818 0.162919639745558 4029 26879 An alkaline phosphatase inhibitor.
SGTC_3278 9139605 49.47 µM -0.983021235824115 0.163852237229711 no 2819 0.162798493589798 4103 7958859
SGTC_1926 methyl fluorone black 53.6 µM -0.983184965506021 0.163811803695422 no 2820 0.162758206446211 3806 72721 Reacts with homocysteine.
SGTC_412 gemfibrozil 100 µM -0.983616472444117 0.163705272793478 no 2821 0.162652061394728 3999 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2962 9082311 13.18 µM -0.984630617533688 0.163455076653144 no 2822 0.162402772323977 4071 16459453
SGTC_2995 9067767 71.4286 µM -0.987338916156487 0.162788139788309 no 2823 0.161738259364665 4100 11673567
SGTC_2304 7443016 91.4 µM -0.989983885606928 0.162138508789594 no 2824 0.161090997744422 3995 939854
SGTC_1594 piperine 70.1 µM -0.990700200495396 0.161962865582573 no 2825 0.16091599657717 4053 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1303 1160-0052 261 µM -0.991679647618789 0.161722902006466 no 2826 0.160676911135163 4031 3562476
SGTC_2794 7785382 27.27 µM -0.992576026101701 0.161503493333668 no 2827 0.160458306368333 4041 2205081
SGTC_2776 terbinafine 19.92 µM -0.998608540514358 0.160031951367883 no 2828 0.15899218063822 4119 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_123 0083-0120 66.675 µM -0.999090747228283 0.159914703845242 no 2829 0.158875366506898 4052 16001701
SGTC_3258 9138477 49.47 µM -0.999193866421714 0.159889637929754 no 2830 0.158850393279946 4110 4970355
SGTC_2681 menadione 3.18 µM -0.999324388810721 0.159857914609934 no 2831 0.158818787284243 4104 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1666 st014829 29 µM -1.00057151652744 0.159555009247885 no 2832 0.158517003180822 4073 3858230
SGTC_742 0kpi-0133 140 µM -1.00236817441363 0.159119293554343 no 2833 0.158082903568333 4136 2728852
SGTC_11 0438-0307 1.3 µM -1.00273549368336 0.159030309342477 no 2834 0.157994249866323 4064 4011476
SGTC_1665 st014639 11.4 µM -1.00300487178129 0.158965072404792 no 2835 0.157929255335426 4148 981133 YIL048W NEO1
SGTC_507 nimesulide 162 µM -1.00399403589801 0.158725670939941 no 2836 0.15769074416388 4154 4495 A COX2 inhibitor.
SGTC_1041 0206-0046 107 µM -1.00555629909904 0.158348047440507 no 2837 0.157314527309338 4102 50494
SGTC_1680 diphenhydramine 100 µM -1.00558630641455 0.158340799976197 no 2838 0.157307306869672 4084 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2585 alliin 100 µM -1.00617034261771 0.158199784994498 no 2839 0.157166817919711 4159 87310 A garlic compound which reacts with lipids.
SGTC_1782 st039423 80.636 µM -1.00754384919531 0.157868478071573 no 2840 0.15683674844671 4127 2068169
SGTC_2934 9036370 36.88 µM -1.0079468041272 0.157771366821476 no 2841 0.156740000329695 4093 6462800
SGTC_1036 k216-0215 33.5 µM -1.01315907149861 0.156518758781071 no 2842 0.15549209322992 4086 622330
SGTC_2332 7982454 138.89 µM -1.01575656476878 0.155896982570257 no 2843 0.154872662254723 4044 2981748
SGTC_3043 9092303 49.47 µM -1.01740736304204 0.155502669348915 no 2844 0.154479840374636 4105 25236084
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.01875270662943 0.155181804729744 no 2845 0.154160191634568 4145 23665772 A membrane-active detergent.
SGTC_1777 st045864 34.765 µM -1.01933102523712 0.155044010083195 no 2846 0.154022919787315 4092 4691462
SGTC_2756 carbadox 75.1 µM -1.01961660043359 0.154975996544528 no 2847 0.153955164437615 4069 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_3151 9099821 49.47 µM -1.02115220788609 0.154610609050908 no 2848 0.153591165619396 4094 17174189
SGTC_768 0384-0033 77.3 µM -1.02132732337658 0.154568977687959 no 2849 0.153549692651487 4075 3965305 YMR134W ERG29
SGTC_2708 st078559 56 µM -1.02346928479253 0.154060354640216 no 2850 0.153043007621907 4052 17250902
SGTC_981 1488-1094 54.9 µM -1.0245472823243 0.153804796256001 no 2851 0.152788424994594 4084 3449522
SGTC_855 0428-0020 25 µM -1.02600682746202 0.15345923266024 no 2852 0.152444182936095 4144 6812414
SGTC_2183 6420625 130.508 µM -1.02824333938737 0.152930711998992 no 2853 0.151917688236244 4097 2897619
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.03054458720144 0.152388154539679 no 2854 0.151377216525434 4162 368090
SGTC_561 1550-0330 72.9 µM -1.0322160320431 0.151994885522285 no 2855 0.150985463145616 4058 6812934
SGTC_293 4049-0273 38.5 µM -1.03478003038495 0.151392921731938 no 2856 0.150385825489374 3999 1380311
SGTC_3355 9151058 44.0485 µM -1.03648086452396 0.15099448349893 no 2857 0.149988931052438 4112 17015728
SGTC_1002 4049-0206 172 µM -1.03693184471026 0.150888953818753 no 2858 0.14988381081218 4104 4662749
SGTC_1965 Pectolinarigenin 58.4 µM -1.0372910812189 0.150804927360766 no 2859 0.149800110530412 4091 5320438 An anti-inflammatory.
SGTC_2181 6316240 54.2555 µM -1.03778028368603 0.150690551594528 no 2860 0.149686178987372 4158 12779990
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.03896098546175 0.150414740970598 no 2861 0.149411440703409 4137 229346 A bile salt which induces apoptosis.
SGTC_2938 9059746 27.26 µM -1.04300249154842 0.149473197022141 no 2862 0.148473569406958 4136 6471769
SGTC_2153 5569715 200 µM -1.04322776625166 0.149420831092483 no 2863 0.14842140828425 4162 2054701
SGTC_2925 9010536 32.5 µM -1.04516333884364 0.148971404825508 no 2864 0.147973742122586 4068 2994177
SGTC_1329 1447-1697 50.6 µM -1.04649852609438 0.148661910684242 no 2865 0.147665462533547 4145 2840515
SGTC_1082 camptothecin 424.86 nM -1.04893359821345 0.148098572609435 no 2866 0.147104340354231 4036 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_57 miconazole 162.5 nM -1.04997020715035 0.147859193955741 no 2867 0.146865905327075 4040 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_495 decylubiquinone 155 µM -1.05078408171337 0.147671431813776 no 2868 0.146678884188397 4208 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2250 alverine citrate 130 µM -1.05104143000974 0.147612094402014 no 2869 0.146619781106926 4027 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2061 5245884 80.95 µM -1.05120323131701 0.147574795666137 no 2870 0.146582629706236 4106 573863
SGTC_3286 9117135 37.221 µM -1.05132744474171 0.147546166042399 no 2871 0.146554113193481 4117 3438150
SGTC_3144 9087057 49.47 µM -1.05186793552213 0.147421633073858 no 2872 0.146430072436545 4026 17249618
SGTC_1253 0550-0034 176 µM -1.0519033269961 0.147413481080976 no 2873 0.146421952675556 4179 5969915
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.05231390642194 0.14731893121384 no 2874 0.146327776748956 4137 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3019 9081971 49.47 µM -1.05280825753674 0.147205144007647 no 2875 0.146214439817603 4171 16451803
SGTC_1235 benzylparaben 21.5 µM -1.05393624993257 0.146945729134965 no 2876 0.1459560525205 4170 7180
SGTC_854 0422-0053 192 µM -1.05525657733957 0.146642470901784 no 2877 0.145653997346048 4158 3596728
SGTC_2419 paclitaxel 166.5 µM -1.05842704618917 0.14591598070958 no 2878 0.14493039719213 4080 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_838 0109-0203 71.4 µM -1.06062410497577 0.145413961544647 no 2879 0.144430381691854 4161 759422
SGTC_2773 thioridazine 9.09 µM -1.06123846234093 0.1452737914332 no 2880 0.144290771993379 4171 5452 An antipsychotic.
SGTC_2965 9082772 38.63 µM -1.06309228137814 0.144851380274075 no 2881 0.14387005222395 4170 16459634
SGTC_3212 9128307 49.47 µM -1.06334714874677 0.144793370934421 no 2882 0.143812275460828 4103 27243542
SGTC_2385 9074692 200 µM -1.06401909407756 0.144640507155084 no 2883 0.143660024904276 4169 17046906
SGTC_3152 9099253 49.47 µM -1.0648796721134 0.144444889322146 no 2884 0.143465192538826 4076 25236131
SGTC_1715 st032160 10.2275 µM -1.06783048788421 0.143775494099601 no 2885 0.142798491397314 4095 5289825
SGTC_667 1498-1044 59 µM -1.06807797586183 0.143719446518391 no 2886 0.142742669827417 4174 6739982
SGTC_2507 purpurin 79.67 µM -1.06828558632505 0.143672441206155 no 2887 0.142695854116066 4175 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1573 oleylamine 1.06 µM -1.06942894336861 0.143413758400079 no 2888 0.142438215590881 4145 5356789 An amine of the fatty acid oleic acid.
SGTC_2403 6032726 181.2 µM -1.07011362440354 0.143259000982332 no 2889 0.142284083609539 4221 2881040
SGTC_2448 5185112 27.17 µM -1.07149473143802 0.142947174772455 no 2890 0.141973519193108 4203 5718189
SGTC_926 2268-1401 59.4 µM -1.07383563219191 0.142419694685133 no 2891 0.14144817835001 4133 2931578
SGTC_3252 9135871 49.47 µM -1.07502421453632 0.142152373533337 no 2892 0.141181943659619 4196 17682838
SGTC_1122 capsaicin 818.572 nM -1.07526328864478 0.142098645007865 no 2893 0.141128433688906 4227 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_177 1327-0068 8.361 µM -1.07741363501048 0.141616002896684 no 2894 0.140647757680669 4177 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_447 ml7 120 µM -1.07790028131135 0.141506930130907 no 2895 0.140539129942993 4188 4216 Selective myosin light chain kinase inhibitor.
SGTC_3059 1327-0034 3 µM -1.07810997176751 0.141459949447197 no 2896 0.140492341025664 4050 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3011 9081274 71.4286 µM -1.07879230312405 0.141307147776778 no 2897 0.140340163397953 4167 6625322
SGTC_2151 5563267 85.4165 µM -1.07941218249314 0.141168428664082 no 2898 0.140202011258552 4210 5310824
SGTC_2569 tetrandrine 100 µM -1.08000824118528 0.141035127345781 no 2899 0.140069255168198 4188 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1812 st052057 4.327 µM -1.08210956101096 0.140565873686649 no 2900 0.139601923956647 4190 3645418
SGTC_1935 st074532 41.6 µM -1.08235171189538 0.14051186624019 no 2901 0.139548138080199 4171 2829742
SGTC_1357 1503-1303 39.5 µM -1.08269563775833 0.140435183910316 no 2902 0.13947177045642 4139 292895
SGTC_2845 9003024 42.97 µM -1.08454421320745 0.140023509037095 no 2903 0.139061787325768 4244 2990173
SGTC_2402 5553605 200 µM -1.08506173027488 0.139908405855572 no 2904 0.138947157820966 4280 6758546
SGTC_2157 5649910 96.377 µM -1.08696705338285 0.139485189105518 no 2905 0.13852568523 4170 2858091
SGTC_2622 2-methoxyxanthone 59.94 µM -1.08762393444285 0.139339482545486 no 2906 0.138380580074254 4176 71034 A hepatoprotective.
SGTC_3266 9136860 49.47 µM -1.08833352841287 0.139182199822929 no 2907 0.138223947065709 4018 4871271 YPR165W RHO1
SGTC_947 3447-0010 211 µM -1.08877993480131 0.139083315017405 no 2908 0.138125471021623 4138 748350
SGTC_2993 9054257 71.4286 µM -1.09244601651058 0.138273039444003 no 2909 0.13731855309756 4113 6470217 YGL055W OLE1
SGTC_2618 avocadyne 43.43 µM -1.09291566854866 0.138169470189297 no 2910 0.137215414072832 4097 3015189
SGTC_404 fumagillin 50 µM -1.09295098976795 0.138161683173807 no 2911 0.137207659414544 4187 12015870 A methionine aminopeptidase binder.
SGTC_2071 5230951 39.92 µM -1.09631824877376 0.137420701585114 no 2912 0.136469763020999 4219 1799272
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.09690609467123 0.137291621977483 no 2913 0.13634122211651 4199 16486 A toxic proline analog.
SGTC_2155 5570423 76 µM -1.09742200077183 0.137178407205285 no 2914 0.136228480145128 4143 797402
SGTC_2966 9084041 48.03 µM -1.09815815998207 0.137016968692931 no 2915 0.136067716321383 4101 17741380
SGTC_2849 9019321 12.99 µM -1.09886684861628 0.136861677123123 no 2916 0.135913074304347 4222 16489627
SGTC_1645 Cervolide 78 µM -1.0990666998355 0.136817906430008 no 2917 0.135869486793208 4185 23173 A fragrance.
SGTC_1765 st044815 90.4 µM -1.10135988687374 0.136316345692126 no 2918 0.13537002819098 4230 645695
SGTC_308 4092-1169 104 µM -1.10516781626934 0.135486265749746 no 2919 0.134543439773619 4127 2268590 YDL196W YDL196W
SGTC_264 promethazine 12.5 mM -1.10685023602798 0.135120625242242 no 2920 0.134179342204479 4081 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_171 k064-0041 9.68 µM -1.1088492577568 0.134687057925837 no 2921 0.133747608411613 4217 53325
SGTC_2891 9063876 19.48 µM -1.10894128314468 0.134667121576056 no 2922 0.133727756474287 4201 6472478
SGTC_254 nsc-64875 3.808 µM -1.11120475854529 0.134177400451209 no 2923 0.133240111729117 4206 56993
SGTC_2154 5570129 200 µM -1.11884139812606 0.13253418491895 no 2924 0.13160390353796 4259 673366
SGTC_327 1273-0057 3.96 µM -1.1228846994249 0.131669803558857 no 2925 0.130743233289144 4091 3108138
SGTC_1900 st060200 72.8 µM -1.12582462380323 0.131043751194606 no 2926 0.130119879649429 4207 688945
SGTC_2471 5466956 24.79 µM -1.1282378910469 0.130531388898865 no 2927 0.129609732804315 4207 724419
SGTC_1389 3405-0187 19 µM -1.12909797145318 0.130349119967361 no 2928 0.129428253484595 4181 799890
SGTC_2763 lisinopril 49.32 µM -1.13032192547916 0.130090042313646 no 2929 0.129170299529054 4110 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2847 9005661 71.43 µM -1.13261725556145 0.129605144939328 no 2930 0.128687509541831 4239 2991449
SGTC_1189 1431-2119 7.28 µM -1.13817069972227 0.128437141868166 no 2931 0.127524605453563 4221 3107275
SGTC_2185 6113692 200 µM -1.13965352123957 0.128126513949233 no 2932 0.127215339042011 4237 874150
SGTC_3157 9099274 49.47 µM -1.1399702947868 0.128060222544368 no 2933 0.127149338494885 4268 17217662
SGTC_679 0422-0091 41.4 µM -1.14254453644136 0.127522392816276 no 2934 0.126613872400218 4252 627384 YHR062C RPP1
SGTC_145 3737-0113 38.366 µM -1.14311982341574 0.127402414610318 no 2935 0.126494422411723 4190 6849351
SGTC_2152 5568786 200 µM -1.14416483441007 0.127184674615767 no 2936 0.126277641921061 4233 5399883
SGTC_3132 9126706 49.47 µM -1.14448820569564 0.127117348996015 no 2937 0.126210613211408 4316 850858
SGTC_1549 4'-methoxyflavonol 74.6 µM -1.14486791607403 0.127038325287771 no 2938 0.126131938141059 4181 97141
SGTC_3352 9151559 45.5865 µM -1.14496207653755 0.127018734304178 no 2939 0.126112433612387 4241 17159339
SGTC_1363 1636-0063 10.4 µM -1.14582704139376 0.126838868476843 no 2940 0.125933361962202 4250 6072185
SGTC_2698 st077697 67.5 µM -1.14598981153075 0.126805040940794 no 2941 0.125899683874503 4199 3154499
SGTC_2729 fluphenazine 10.66 µM -1.14624004534978 0.126753048606929 no 2942 0.1258479212937 4161 3372 An atypical antipsychotic.
SGTC_860 0443-0016 25.1 µM -1.15002032746566 0.125969406062627 no 2943 0.125067749523648 4265 5337942
SGTC_165 k038-0023 64.381 µM -1.15132353837572 0.125700038572003 no 2944 0.12479957848788 4239 46368543
SGTC_1290 0986-0249 10.2 µM -1.15247994522815 0.12546135149536 no 2945 0.12456195305811 4096 53329
SGTC_1080 nisoldipine 24.4 µM -1.15315164348993 0.125322855565539 no 2946 0.124424073771231 4242 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1297 1068-0111 14.1 µM -1.15961187849043 0.123996282985025 no 2947 0.123103431272634 4225 767057
SGTC_3269 9137823 49.47 µM -1.16161308462129 0.1235873473704 no 2948 0.122696332352986 4163 17682936
SGTC_2844 9010103 25.97 µM -1.16343445634605 0.123215981749832 no 2949 0.122326638237797 4272 2480525
SGTC_2909 7941780 10.49 µM -1.16649778021246 0.122593155351425 no 2950 0.121706622777093 4241 1243215
SGTC_2843 9000894 45.46 µM -1.1670329088757 0.122484581514523 no 2951 0.121598539934242 4187 2242070
SGTC_2898 9056270 58.44 µM -1.16809162194862 0.122269974930573 no 2952 0.121384904703951 4246 19154699
SGTC_18 0111-0177 500 nM -1.16972424981472 0.121939550472437 no 2953 0.121055978043414 4336 721752
SGTC_1279 0874-0590 65.2 µM -1.17237432867222 0.121404542273712 no 2954 0.120523400753394 4318 3523074
SGTC_2522 biochanin a 4.94 µM -1.17437598585942 0.121001535499599 no 2955 0.120122229817749 4274 5280373 A possible chelator.
SGTC_2722 naftopidil 47.16 µM -1.17517264228735 0.120841401581548 no 2956 0.119962826491006 4206 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_791 1348-1292 225 µM -1.17800529704253 0.120273224924986 no 2957 0.119397247244809 4240 5437054
SGTC_881 0833-0569 170 µM -1.17847834426473 0.120178524347052 no 2958 0.119302980375457 4278 5418700
SGTC_2148 5546263 113.568 µM -1.18083474140152 0.119707573694158 no 2959 0.118834189922858 4260 792097
SGTC_1145 3546-0597 10.2 µM -1.18268171839916 0.11933934696884 no 2960 0.118467656103947 4238 875334
SGTC_2254 7938975 95.19 µM -1.18389482337528 0.119097928899132 no 2961 0.118227349800713 4347 2969277
SGTC_1513 0337-0559 19 µM -1.18435140137344 0.119007155412149 no 2962 0.118136994720434 4249 775073
SGTC_1191 1487-1166 10.6 µM -1.18517469228211 0.118843598242632 no 2963 0.117974191969456 4311 3955771
SGTC_870 0573-2213 57.6 µM -1.18518806128811 0.118840943630869 no 2964 0.117971549607857 4263 3916321
SGTC_693 4161-2696 114 µM -1.1872577813472 0.118430475461177 no 2965 0.117562977764532 4311 805759
SGTC_2499 avocadenofuran 51.48 µM -1.18810089509945 0.118263556198081 no 2966 0.117396830877279 4239 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_952 1185-0122 232 µM -1.19147453716058 0.117597308800399 no 2967 0.116733673436497 4236 678600
SGTC_893 0958-0369 48.9 µM -1.19245733065151 0.117403721461327 no 2968 0.116540986051739 4190 6819948
SGTC_1298 1079-1278 263 µM -1.20195052867324 0.11554539530023 no 2969 0.114691347923368 4260 2840950
SGTC_1416 3966-0321 25.3 µM -1.2046006363342 0.115030379251901 no 2970 0.114178755476405 4327 582530 YLR208W SEC13
SGTC_1631 benzylvanillin 81.9 µM -1.20644479157192 0.114672954805753 no 2971 0.113823017083266 4351 75506
SGTC_166 k072-0058 166.424 µM -1.20704094411166 0.114557580871009 no 2972 0.113708188105398 4174 5846229
SGTC_533 1222-0222 6.71 µM -1.20770237095583 0.114429671051214 no 2973 0.113580882860976 4314 3982874
SGTC_1707 st032323 6.317 µM -1.20807150665992 0.114358330081174 no 2974 0.113509879275238 4148 3132057 YMR211W DML1
SGTC_3215 9129942 49.47 µM -1.20880910940967 0.114215872241008 no 2975 0.11336809554241 4275 17682944
SGTC_1772 st048439 82.2 µM -1.20902519571232 0.114174162085526 no 2976 0.113326582859036 4350 2927068 YDL195W SEC31
SGTC_1519 esterone 74 µM -1.20967260103019 0.114049261328647 no 2977 0.11320227370363 4258 698 A steroid.
SGTC_56 0957-0365 83.25 µM -1.20981848634803 0.114021129827466 no 2978 0.113174275505776 4261 6752360
SGTC_2455 5377712 9.75 µM -1.21265930391431 0.113474311629003 no 2979 0.112630052576976 4281 2243908
SGTC_2861 9024595 19.48 µM -1.21317381544756 0.113375475608913 no 2980 0.11253168648479 4203 16482810
SGTC_2641 levomentholum 100 µM -1.2134148479996 0.113329195151882 no 2981 0.112485626162327 4285 16666
SGTC_2442 5158906 48.48 µM -1.21516864482165 0.112992855812721 no 2982 0.112150888330387 4301 1893835
SGTC_438 sphingosine 6.67 µM -1.21594721201006 0.112843772450163 no 2983 0.112002515796393 4229 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2819 7996655 46.38 µM -1.21774161752611 0.112500706958599 no 2984 0.111661088273908 4254 6456960
SGTC_2676 harmalol 100 µM -1.21778398188758 0.112492616491679 no 2985 0.111653036472643 4262 5459187 A monoamine oxidase inhibitor
SGTC_297 0986-0032 24 µM -1.21998135906068 0.112073545584561 no 2986 0.111235970750519 4256 2847425
SGTC_2978 9011784 42.97 µM -1.22067816720334 0.111940887780202 no 2987 0.111103948665075 4277 2994934
SGTC_2906 7926292 26.41 µM -1.22088424472994 0.111901676419358 no 2988 0.111064925301534 4296 2966319
SGTC_3246 9135460 32.98 µM -1.22183096341604 0.111721665915464 no 2989 0.1108857783768 4280 41446951
SGTC_1484 3473-2379 286 µM -1.22290535014239 0.111517631455422 no 2990 0.110682723793558 4426 671917
SGTC_3010 9080089 71.4286 µM -1.22326963074757 0.11144851228165 no 2991 0.110613936817269 4319 17027233
SGTC_443 clozapine 122 µM -1.22360299946815 0.111385285249922 no 2992 0.110551013776349 4271 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2135 5326629 150.42 µM -1.22399642839127 0.111310700176683 no 2993 0.110476787440021 4250 5020077
SGTC_525 k781-2675 26.7 µM -1.22462632795254 0.111191360164948 no 2994 0.110358021735851 4265 3651118 YDL195W SEC31
SGTC_2795 7780010 54.55 µM -1.23166860570899 0.109863372712445 no 2995 0.109036450868745 4280 953673
SGTC_891 0929-0073 133 µM -1.23193622064716 0.109813133078882 no 2996 0.10898645491759 4345 5603632
SGTC_1243 0416-0003 5.65 µM -1.23224164231499 0.109755816099341 no 2997 0.108929416031887 4303 2141977
SGTC_1408 3909-7976 48.8 µM -1.23299166642574 0.109615153897321 no 2998 0.108789436680123 4363 24152374
SGTC_3052 9092717 49.47 µM -1.23413942432154 0.109400149949795 no 2999 0.108575477514806 4314 25237534
SGTC_3226 9131256 49.47 µM -1.23740467059864 0.108790144207256 no 3000 0.107968442853164 4272 17178073
SGTC_6 0844-0013 19.835 µM -1.23807947800519 0.108664383791227 no 3001 0.107843296224123 4457 1584900
SGTC_1845 st056753 3.01 µM -1.23844651519876 0.108596024858075 no 3002 0.107775271105178 4296 5375839
SGTC_1612 st002233 45.4 µM -1.24148326441843 0.108031631182016 no 3003 0.107213638394811 4327 1035021
SGTC_1287 0971-0001 34.6 µM -1.24374996901666 0.107611732527624 no 3004 0.106795799519657 4313 4665869
SGTC_1447 4239-0816 81.9 µM -1.24504820939245 0.107371768591267 no 3005 0.106557014886739 4326 1341554
SGTC_617 3770-0098 35 µM -1.24549400791712 0.107289457192459 no 3006 0.106475108373379 4237 5962639
SGTC_1352 1496-0991 99 µM -1.24805491876766 0.106817496645214 no 3007 0.106005472990621 4322 3000039
SGTC_1375 2910-0797 186 µM -1.25278048556347 0.105950539093762 no 3008 0.105142802701808 4321 742508
SGTC_2957 9076800 11.52 µM -1.25389824316353 0.105746219791805 no 3009 0.104939496844799 4300 16459615
SGTC_746 1095-0025 46.6 µM -1.25550870983824 0.105452337345913 no 3010 0.104647074133194 4344 6749286
SGTC_3131 9127911 49.47 µM -1.26458557685571 0.103807008908359 no 3011 0.103009963017748 4366 45595681
SGTC_1802 st050112 57.9 µM -1.26569731502732 0.103606775619902 no 3012 0.102810734987668 4328 4662563
SGTC_9 0092-0002 10.449 µM -1.26667711712194 0.103430537589653 no 3013 0.102635382692625 4340 759368
SGTC_2595 hexamethylquercetagetin 100 µM -1.27611657209447 0.101743789837 no 3014 0.100957157117892 4349 386331
SGTC_1605 st000082 49.1 µM -1.2765066131739 0.1016745263067 no 3015 0.100888245285543 4313 1114022
SGTC_2553 4-methylesculetin 85.09 µM -1.27869839406921 0.10128594809336 no 3016 0.100501642720636 4376 5319502
SGTC_1624 st003710 6.25 µM -1.27906468133645 0.101221115124293 no 3017 0.100437139807653 4385 24207033
SGTC_2478 5763493 32.33 µM -1.28009534503192 0.101038849571934 no 3018 0.100255802798657 4289 1365576 YLR208W SEC13
SGTC_3076 9116187 49.47 µM -1.28123188906557 0.100838137318849 no 3019 0.100056114181569 4329 27241210
SGTC_1807 st050092 58.9 µM -1.28387776464516 0.100372005548747 no 3020 0.0995923642184135 4366 5008496
SGTC_7 0192-1582 4.227 µM -1.28435250300888 0.100288536126534 no 3021 0.0995093219718134 4401 252616
SGTC_1915 st067105 30.6 µM -1.28582655722967 0.100029687935285 no 3022 0.0992517997969345 4300 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2420 aureobasidin a 50 nM -1.28751551838167 0.0997337015739908 no 3023 0.0989573321083479 4437 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2608 thymoquinone 42.66 µM -1.28769475267101 0.0997023287911135 no 3024 0.0989261204464377 4316 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2092 5303694 80.6725 µM -1.29175353250607 0.0989938180009637 no 3025 0.0982212560672573 4354 1963699
SGTC_2636 apigenin dimethyl ether 100 µM -1.29185628469382 0.0989759292460544 no 3026 0.0982034595700603 4338 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1662 st014054 52 µM -1.29882204899022 0.0977687248010483 no 3027 0.0970025029845341 4419 2838777
SGTC_2303 7774051 200 µM -1.29997123362162 0.0975706066443141 no 3028 0.0968054143315474 4373 2953184
SGTC_1185 1319-0113 81.3 µM -1.3007839190267 0.0974306784083975 no 3029 0.0966662139283616 4427 4672763
SGTC_528 3492-0019 172 µM -1.30476324668968 0.0967476420848312 no 3030 0.0959867388354969 4369 2869262
SGTC_2975 9084847 53.72 µM -1.30489727443105 0.0967246981090855 no 3031 0.0959639147293045 4374 27211724
SGTC_2438 5259590 200 µM -1.30682810026221 0.0963946067452635 no 3032 0.0956355496686002 4373 1201127
SGTC_1545 lovastatin 49.4 µM -1.30874687399975 0.0960673966061617 no 3033 0.0953100540169324 4403 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1108 betulinic acid 729.144 nM -1.31134821294006 0.0956250931584934 no 3034 0.0948700732765218 4360 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1924 st058459 75.1 µM -1.31547583560451 0.0949263550487196 no 3035 0.0941750166613517 4327 688683
SGTC_1518 st038567 90.8 µM -1.31964847540636 0.0942238269247863 no 3036 0.0934762050848301 4330 77966
SGTC_2156 5649887 115 µM -1.32352047729517 0.093575353297462 no 3037 0.0928311755505579 4409 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1712 st032288 53.4 µM -1.32516056729201 0.0933016708093657 no 3038 0.09255895052143 4202 2883011
SGTC_858 0438-0351 2.77 µM -1.32705505131134 0.0929862741067417 no 3039 0.0922452363107436 4363 2799119
SGTC_144 4161-2749 112.381 µM -1.32945208752978 0.092588342075607 no 3040 0.0918494314865137 4358 797501 YMR168C CEP3
SGTC_2439 5492030 7.2 µM -1.33068267285447 0.0923845425968035 no 3041 0.0916467233676391 4388 5722370
SGTC_2228 7354201 200 µM -1.33988952498281 0.0908703014658741 no 3042 0.0901406320662424 4478 753451
SGTC_118 0083-0097 135.343 µM -1.34110339488605 0.0906720395683664 no 3043 0.0899434426169174 4372 5207356
SGTC_1299 1079-1439 3.74 µM -1.34134588150348 0.0906324726264833 no 3044 0.0899040898524108 4367 323161
SGTC_1846 st056244 14.8 µM -1.3437806200866 0.0902359024415716 no 3045 0.0895096690777195 4418 5393182
SGTC_2206 7254556 146.969 µM -1.34602662279841 0.0898712177605282 no 3046 0.0891469654297717 4434 4398905
SGTC_1415 3966-0071 78.1 µM -1.34673107247364 0.089757061856584 no 3047 0.0890334305184454 4310 2893185
SGTC_2565 isoliquiritigenin 100 µM -1.34772083120717 0.0895968538556069 no 3048 0.0888740947339888 4423 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2091 4-phenylthiadiazole 200 µM -1.35395469224509 0.0885926897953576 no 3049 0.087875416496589 4408 270010
SGTC_2214 7179297 48.276 µM -1.35495079050707 0.0884330159414375 no 3050 0.0877166179658803 4476 769744
SGTC_864 0469-0573 172 µM -1.35579507788208 0.088297845247767 no 3051 0.0875821889193651 4382 689425
SGTC_2184 6075246 200 µM -1.35605975046593 0.0882555027954135 no 3052 0.0875400789117744 4385 2267320
SGTC_423 5-fluorouracil 457 µM -1.3585289294386 0.0878612112397806 no 3053 0.0871479546857315 4336 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3209 9113616 49.47 µM -1.35873742269859 0.0878279781821579 no 3054 0.0871149045349236 4439 16649353
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.35992005520711 0.0876396483236657 no 3055 0.0869276118828376 4409 551469
SGTC_712 r015-0009 80.6 µM -1.36210115022724 0.0872931075508018 no 3056 0.086582982689232 4435 6813872 YLR060W FRS1
SGTC_1848 st056003 16.4 µM -1.36271700647181 0.0871954433968578 no 3057 0.0864858579815438 4414 146492
SGTC_2886 9058944 51.95 µM -1.36582135672439 0.0867043890095108 no 3058 0.0859975206956516 4344 4949929
SGTC_1828 st055811 49 µM -1.36896052164549 0.0862099321503892 no 3059 0.0855058078355354 4422 5877589
SGTC_821 1114-0266 29.2 µM -1.37464062074698 0.0853206128162528 no 3060 0.0846214443085767 4443 3123235
SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.37861287462734 0.08470278241104 no 3061 0.0840070724395532 4439 77254
SGTC_85 0868-0259 160.055 µM -1.37941125313343 0.0845790113793008 no 3062 0.0838839958109719 4346 83173
SGTC_521 r062-0005 13.8 µM -1.38012027308776 0.0844692072064277 no 3063 0.0837748081157693 4344 2832033
SGTC_628 1636-0253 16 µM -1.38097538616703 0.0843369202682173 no 3064 0.0836432644236238 4409 4456143
SGTC_2552 juarezic acid 87.02 µM -1.38252239802564 0.0840979909688287 no 3065 0.0834056790389792 4367 1549512
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.38370377013264 0.0839158756187033 no 3066 0.083224589343676 4441 66535 A nucleotide analog.
SGTC_3111 9122088 49.47 µM -1.3838029611 0.083900598244409 no 3067 0.0832093980613218 4327 16876704
SGTC_612 0302-0167 22.4 µM -1.38805483854529 0.0832476869414789 no 3068 0.0825601735319467 4438 235821
SGTC_3302 9125395 16.351 µM -1.38899332900962 0.0831040899049565 no 3069 0.0824173892989422 4377 17599668
SGTC_1485 3909-9022 254 µM -1.39631380838038 0.0819903812419935 no 3070 0.081310008709741 4498 714516
SGTC_2778 tioconazole 65.09 nM -1.39979759412796 0.0814643378455159 no 3071 0.080786969246059 4325 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_321 4534-3890 65.3 µM -1.40146294842474 0.0812137742896413 no 3072 0.0805378399133308 4436 699746
SGTC_2457 5731572 11.68 µM -1.40292685245519 0.0809940008606931 no 3073 0.080319326276643 4483 2865357
SGTC_468 gf-109203x 121 µM -1.40346737229686 0.0809129671059334 no 3074 0.0802387574541682 4498 2396 A protein kinase C inhibitor.
SGTC_1678 st019265 80.2 µM -1.40656925481351 0.0804491214856856 no 3075 0.079777577604573 4432 5367020
SGTC_2642 cholecalciferol 100 µM -1.40733023671973 0.0803356341544143 no 3076 0.0796647436535372 4431 9821465 A vitamin D precursor, similar to steriods.
SGTC_2121 5257820 149.641 µM -1.40847247812659 0.0801655156731201 no 3077 0.0794956054485879 4468 791256
SGTC_708 3448-5400 146 µM -1.41584792928914 0.0790736103960493 no 3078 0.0784100165812324 4386 3462195
SGTC_1402 3909-7673 35.9 µM -1.41640157421958 0.078992102244523 no 3079 0.0783289816440554 4464 5328014
SGTC_3139 9095020 49.47 µM -1.41743296680177 0.0788404293357173 no 3080 0.0781781899423871 4311 25236292
SGTC_178 4092-0806 87.505 µM -1.41783679141705 0.0787811044730179 no 3081 0.0781192099772949 4327 2169044
SGTC_1220 1838-0075 193 µM -1.41933638420628 0.0785610990447723 no 3082 0.0779004847035629 4376 5529645
SGTC_2417 cerulenin 830 nM -1.4220299875374 0.0781670901811579 no 3083 0.077508772842238 4452 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1015 4130-4525 82 µM -1.42507080030835 0.0777240961669066 no 3084 0.0770683681242345 4461 1363237
SGTC_2212 7123476 200 µM -1.42634566446774 0.077538938429051 no 3085 0.0768842947474405 4469 1085715
SGTC_2150 5556613 200 µM -1.43104993886577 0.0768586001856037 no 3086 0.0762079516124474 4486 743190
SGTC_2089 5281248 129.67 µM -1.43140301448 0.0768077215991521 no 3087 0.0761573724795915 4439 2737878
SGTC_1448 4255-0083 152 µM -1.4332504251863 0.0765419251135594 no 3088 0.0758931419290282 4475 5399660
SGTC_3045 9092950 49.47 µM -1.43382141439264 0.0764599156600963 no 3089 0.0758116161586794 4439 44120432
SGTC_2233 sulbentine 40.3845 µM -1.44523183628068 0.0748350531136409 no 3090 0.0741963884069586 4461 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2232 chlorophetanol 41.5365 µM -1.44754313693683 0.0745091523170313 no 3091 0.0738724319778049 4538 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2624 nerol 100 µM -1.4487381106047 0.0743410826277411 no 3092 0.07370536658193 4382 637566 A natural product oil.
SGTC_598 3937-0236 20.2 µM -1.44891772464807 0.0743158454627929 no 3093 0.0736802803128935 4534 1379313
SGTC_2715 st079500 56.4 µM -1.45178149480236 0.0739143467523203 no 3094 0.0732811854580231 4458 28246688
SGTC_698 k064-0052 127 µM -1.45338690635127 0.0736899953134724 no 3095 0.0730581799266375 4548 5088751
SGTC_179 1273-0063 6.77 µM -1.45851004130979 0.0729775332115357 no 3096 0.0723500047133901 4443 3108139
SGTC_331 k048-0133 24.5 µM -1.46506055674055 0.072074263800526 no 3097 0.0714521983749295 4444 6813582
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.46834436323929 0.0716246875961507 no 3098 0.0710053530625613 4500 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_228 caffeine 993.056 µM -1.46839346516382 0.0716179815608195 no 3099 0.070998687821888 4469 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1886 st057356 49.9 µM -1.47389408124157 0.0708697869913821 no 3100 0.07025505580394 4465 24207747
SGTC_657 3534-0529 86.7 µM -1.47552414266429 0.0706492231826065 no 3101 0.0700358412189646 4508 1049549
SGTC_411 enrofloxacin 100 µM -1.47686611409158 0.0704680371159512 no 3102 0.0698557649364405 4515 71188 A bacterial gyrase inhibitor.
SGTC_160 3453-0671 289.699 µM -1.4773750571773 0.0703994157469724 no 3103 0.0697875642205494 4477 5322268
SGTC_2260 7964312 200 µM -1.48263250811819 0.0696935512763204 no 3104 0.0690860376218366 4512 231951
SGTC_1515 3460-0031 42.1 µM -1.4877338067603 0.0690138719944445 no 3105 0.0684105541489275 4458 2876596
SGTC_910 3454-3003 490 µM -1.48805486483889 0.0689712668194594 no 3106 0.068368212604929 4402 820824
SGTC_2703 st077852 53.4 µM -1.49593741970407 0.0679315799660049 no 3107 0.0673349819316206 4535 6281836
SGTC_949 1165-0505 146 µM -1.496924620121 0.0678022282999094 no 3108 0.0672064365901605 4461 6244267
SGTC_775 4577-0580 57.3 µM -1.49812957678685 0.0676446022050487 no 3109 0.0670497939991242 4515 2006902
SGTC_3319 9138450 16.7555 µM -1.50587914326518 0.0666376016488392 no 3110 0.0660491007944741 4434 2029690
SGTC_2804 7954240 19.48 µM -1.51134389495211 0.0659344998693093 no 3111 0.0653504279079295 4511 828705
SGTC_1092 toremifene 6.32 µM -1.51230806887581 0.0658110468394581 no 3112 0.0652277546582518 4497 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1913 st060213 96.1 µM -1.51250864194615 0.0657853879474974 no 3113 0.0652022579189589 4485 688959
SGTC_800 3448-7362 155 µM -1.5130264580359 0.0657191806730569 no 3114 0.0651364691729 4575 15991913
SGTC_252 miconazole 1.30953 nM -1.51675813097917 0.0652435803337916 no 3115 0.0646638807780444 4419 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1494 4358-1428 177 µM -1.51836603982938 0.0650394779812073 no 3116 0.0644610739320392 4518 1564571
SGTC_2810 7959871 45.46 µM -1.52116904235452 0.0646848599650839 no 3117 0.0641087110152399 4461 2974535
SGTC_673 1082-0474 110 µM -1.52199999031528 0.0645800227964198 no 3118 0.0640045415595344 4492 3098046
SGTC_281 1672-3440 14.9 µM -1.52829837327777 0.0637896690537499 no 3119 0.063219236814948 4551 6833000
SGTC_1028 k015-0029 4.8 µM -1.52859637103764 0.0637524619951174 no 3120 0.0631822681094914 4480 4588309
SGTC_1266 0828-0227 32.9 µM -1.53192416244185 0.0633381105314525 no 3121 0.0627705750934769 4485 3913820
SGTC_1539 benzyladenosine 56 µM -1.53300126292716 0.0632044481450469 no 3122 0.0626377718682596 4523 92208 A nucleotide analog.
SGTC_1769 st044406 64.4 µM -1.54085315308949 0.0622366971763521 no 3123 0.0616762648047396 4497 670903
SGTC_1251 0490-5699 265 µM -1.54158172352024 0.062147489551447 no 3124 0.0615876348224224 4525 3883818
SGTC_3124 9127567 49.47 µM -1.54231246479781 0.0620581163531879 no 3125 0.0614988406923954 4469 17592030
SGTC_1673 st016611 27.3 µM -1.54267570154915 0.0620137280680018 no 3126 0.0614547401401353 4505 5226799
SGTC_472 calcifediol 10 µM -1.54568332217798 0.0616471418140834 no 3127 0.0610905335133556 4551 5283731 A vitamin D metabolite.
SGTC_3328 9140624 29.0385 µM -1.54711941400246 0.0614727005139629 no 3128 0.0609172266702599 4501 4904392
SGTC_2231 micatex 6.853 µM -1.54965735117548 0.0611653616566008 no 3129 0.0606118898659909 4555 20737 An antifungal of unknown mechanism.
SGTC_2016 5121758 140 µM -1.55228959910232 0.060847871888592 no 3130 0.0602964727320898 4444 2795203
SGTC_2064 5220758 200 µM -1.56504188343295 0.0593279579684598 no 3131 0.0587865444949902 4550 788518
SGTC_924 2046-0044 21.3 µM -1.56570456107866 0.059249796098273 no 3132 0.0587088990026249 4508 3623589
SGTC_2774 tamoxifen 10.92 µM -1.56771643648635 0.0590129929513304 no 3133 0.0584736620245648 4506 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_342 k048-0088 23.3 µM -1.56905237361917 0.0588561601929802 no 3134 0.0583178679576852 4532 6820570
SGTC_223 busulfan 5 mM -1.573176749928 0.0583740406776973 no 3135 0.057838948654478 4525 2478 A DNA alkylator.
SGTC_921 1561-0023 372 µM -1.5804439691342 0.0575320916577232 no 3136 0.0570026144684276 4516 24050882
SGTC_261 5-fluorouridine 15.376 µM -1.5816437267186 0.0573940161026452 no 3137 0.0568654629162654 4554 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2205 7238770 200 µM -1.58470597308475 0.0570427756617028 no 3138 0.0565165770685029 4577 279867
SGTC_3197 9113331 49.47 µM -1.58573657810815 0.0569249463473617 no 3139 0.0563995389597532 4516 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2004 4023728 41.89 µM -1.5878113119927 0.056688322869365 no 3140 0.0561645063807205 4489 360084 YDR527W RBA50
SGTC_1443 4112-3303 14 µM -1.58801452932044 0.0566651876512774 no 3141 0.0561415268526887 4577 704433
SGTC_847 0342-0274 5.54 µM -1.58864280278795 0.0565937090836881 no 3142 0.0560705294676696 4531 18097
SGTC_225 nsc-122657 1.016 µM -1.59013994244217 0.0564236660966171 no 3143 0.0559016321721931 4558 275685
SGTC_1698 5-fluorocytosine 1.055 µM -1.59579766117705 0.0557847041417299 no 3144 0.0552669878272448 4556 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_975 1335-0046 28.5 µM -1.59732411728713 0.0556132934582489 no 3145 0.0550967387814247 4534 16486740
SGTC_1050 3232-1156 69.3 µM -1.59738674605633 0.0556062695597537 no 3146 0.0550897625139778 4495 700529
SGTC_1397 3532-0190 20.1 µM -1.59781459727304 0.0555583042147654 no 3147 0.0550421225000799 4540 5322280
SGTC_3025 9087895 49.47 µM -1.60495876310416 0.0547622055858777 no 3148 0.0542514400139903 4533 17173641
SGTC_557 1315-0110 16.2 µM -1.60884263912549 0.0543332113238427 no 3149 0.0538253773482536 4535 6833801
SGTC_1439 4092-1168 46 µM -1.61221088542671 0.053963327611718 no 3150 0.0534580286616623 4570 2886240
SGTC_1805 st050013 60.3 µM -1.61231387260038 0.05395204956899 no 3151 0.0534468280215316 4507 4037144
SGTC_3283 9109332 35.8195 µM -1.61602357980005 0.0535470452995898 no 3152 0.0530446075883125 4382 17027281
SGTC_2899 9053889 58.44 µM -1.6229424703734 0.0527981197816427 no 3153 0.0523008517674258 4563 6470052
SGTC_717 1532-0246 73.2 µM -1.62344200154331 0.0527443720037751 no 3154 0.0522474761005992 4549 9561992
SGTC_360 0957-0399 1.01 µM -1.62833126529848 0.0522205935807962 no 3155 0.051727331713133 4570 6752301 YPR165W RHO1
SGTC_2235 salicylic acid 500 µM -1.62951611840249 0.0520942861796051 no 3156 0.0516019027647881 4630 338 A COX inhibitor and kinase inhibitor.
SGTC_2550 chrysin dimethyl ether 71.87 µM -1.64131201977492 0.0508500163515513 no 3157 0.0503663311408104 4442 88881 An O-methylated flavonoid and antioxidant.
SGTC_2305 7443522 69.23 µM -1.64294230553513 0.0506799252717028 no 3158 0.0501974354285958 4466 5415886
SGTC_751 0833-0568 350 µM -1.64489573316294 0.0504767172209875 no 3159 0.0499956574992971 4571 6954252
SGTC_3231 9132313 49.47 µM -1.64900598419786 0.0500512627325191 no 3160 0.0495732043753293 4541 4905967
SGTC_2644 guaiazulene 100 µM -1.65176408022299 0.0497673771833083 no 3161 0.0492913268947271 4600 3515 A coloring agent.
SGTC_1013 4112-3890 241 µM -1.65324088052239 0.0496159018284608 no 3162 0.0491409247808061 4548 705171
SGTC_1257 0669-0121 16 µM -1.65943284570071 0.0489847932026988 no 3163 0.0485143011180571 4559 4307855
SGTC_643 k048-0106 28.4 µM -1.65985517805666 0.0489419821933992 no 3164 0.048471795131161 4603 6763920
SGTC_1285 0929-0069 65.5 µM -1.66319638669623 0.0486043432579777 no 3165 0.0481365653496425 4612 1206237
SGTC_1396 3511-0007 98.6 µM -1.66622251434192 0.0483001536779085 no 3166 0.0478345516311704 4593 X1396
SGTC_1534 6-azauridine 81.6 µM -1.66691036116186 0.0482312234428814 no 3167 0.0477661151643084 4615 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_3200 9114385 49.47 µM -1.6694074010692 0.0479816522617826 no 3168 0.0475183339451752 4537 17018030 YLR208W SEC13
SGTC_1743 st037606 46.3785 µM -1.67103163308017 0.0478198710372051 no 3169 0.0473577148938647 4535 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1248 0469-0687 58.6 µM -1.67172560825987 0.0477508811119246 no 3170 0.0472892210101999 4532 4017482
SGTC_441 propafenone 146 µM -1.67583980473445 0.0473435131816952 no 3171 0.0468847875234501 4563 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2055 5235184 200 µM -1.67695371772062 0.0472336992965623 no 3172 0.0467757662733872 4577 2836034
SGTC_17 0960-0276 49.807 µM -1.68117826674326 0.0468190809566349 no 3173 0.0463641468016031 4577 6821114
SGTC_2441 5730946 39.09 µM -1.68552927253233 0.0463951085119657 no 3174 0.0459432510131979 4615 1774275
SGTC_720 r052-1644 49.9 µM -1.68802708618542 0.0461531115514512 no 3175 0.0457030147851559 4589 1422863 YOR257W CDC31
SGTC_1742 st038235 28.8875 µM -1.70781872038962 0.0442712804370412 no 3176 0.0438349921847687 4605 564103 YBR002C RER2
SGTC_627 1391-0720 175 µM -1.71561706400457 0.0435469940761603 no 3177 0.0431160766182337 4588 997839
SGTC_814 3342-0569 96 µM -1.7161355582604 0.0434991789925892 no 3178 0.0430686172148407 4630 4346283
SGTC_2699 st077704 54.6 µM -1.71616517979006 0.0434964486014109 no 3179 0.043065907138315 4588 645852
SGTC_1097 itavastatin 7.23 µM -1.71621305373248 0.0434920360701119 no 3180 0.0430615274380846 4616 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1522 st012842 45.6 µM -1.72242997751378 0.0429220865513448 no 3181 0.0424958285853468 4446 3491067 YOR116C RPO31
SGTC_1341 1486-1360 280 µM -1.72372417169235 0.0428042009084375 no 3182 0.0423788246199831 4601 3976547
SGTC_1785 bathophenanthroline 24 µM -1.73186956229693 0.0420682471358289 no 3183 0.0416483946034332 4542 72812 An iron chelator.
SGTC_960 1222-0186 7.7 µM -1.73389790683702 0.0418865835033209 no 3184 0.0414680996692496 4589 3126296
SGTC_1686 st019653 115.5 µM -1.73477343793279 0.0418083652453659 no 3185 0.0413904713664491 4596 97252
SGTC_986 1493-0483 84 µM -1.73685679898877 0.0416227173336151 no 3186 0.0412062252360467 4581 40079
SGTC_957 1187-1561 14.1 µM -1.73736843976529 0.0415772274071735 no 3187 0.0411610791254089 4549 1538454
SGTC_340 k038-0059 454 µM -1.74192041436035 0.0411742826887872 no 3188 0.0407611856321919 4595 23733424
SGTC_1014 4130-3005 69.3 µM -1.74310203463438 0.0410702038969378 no 3189 0.0406578966418795 4607 743608
SGTC_2564 betulinic acid 100 µM -1.75398836287062 0.0401213250583362 no 3190 0.0397162505918982 4587 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2415 st077333 57.7 µM -1.76002133474951 0.039603194876784 no 3191 0.0392020946390066 4593 2766255
SGTC_792 4534-1957 155 µM -1.76971768661636 0.0387818547847636 no 3192 0.0383870910198324 4588 1717904
SGTC_430 0958-0115 16.4 µM -1.77471445158968 0.0383640469898371 no 3193 0.0379725239490666 4543 6833180
SGTC_1100 amiodarone 5.07 µM -1.77491192676598 0.0383476106449765 no 3194 0.0379562153351582 4634 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1972 st070201 17.4 µM -1.77879921031729 0.0380252296300739 no 3195 0.0376363433574389 4628 2829099
SGTC_1265 0819-1001 68.8 µM -1.78214177847527 0.0377497941091397 no 3196 0.0373630571605227 4563 3106768
SGTC_2210 7115885 190.385 µM -1.78331832683861 0.0376532320784136 no 3197 0.0372672498792302 4694 2927039
SGTC_613 3914-0030 117 µM -1.78917820289851 0.0371752974529355 no 3198 0.036793060440601 4381 1145395
SGTC_1583 clindamycin 39.6 µM -1.79142179697442 0.0369936260537421 no 3199 0.0366128168455911 4625 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_748 act1.228 77.9 µM -1.79175442756872 0.0369667537070883 no 3200 0.0365861558930653 4602 4421505 YNR035C ARC35
SGTC_2748 diazoxide 86.69 µM -1.7981466867708 0.03645343263824 no 3201 0.0360768827314626 4700 3019 A potassium channel activatior.
SGTC_2440 5628896 157.78 µM -1.79928806220892 0.0363623927739566 no 3202 0.035986562739552 4597 5522048
SGTC_977 1348-1378 135 µM -1.80786510234054 0.0356841978017988 no 3203 0.0353137491625655 4608 X977
SGTC_1722 st034304 3.6505 µM -1.8132439463739 0.0352642015166701 no 3204 0.0348971022475299 4568 4036148 YLR033W RSC58
SGTC_2208 7283366 200 µM -1.81338899655449 0.0352529319533727 no 3205 0.034885922734477 4631 898663
SGTC_2840 9008771 71.43 µM -1.81524290743668 0.0351091537712865 no 3206 0.0347432942433895 4592 2992978
SGTC_645 0845-0943 5.41 µM -1.81716850493552 0.0349603257908628 no 3207 0.0345956579420594 4646 1885106
SGTC_1786 berberine 21.6 µM -1.81816485022126 0.0348835225295761 no 3208 0.0345194702935394 4550 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2207 7258803 200 µM -1.81964533738033 0.0347696550659811 no 3209 0.0344065163358489 4657 3666799
SGTC_1687 st020778 55.3625 µM -1.82595105858693 0.0342880816771981 no 3210 0.0339288171061955 4665 4259299
SGTC_1685 st024049 53.0905 µM -1.8312723423368 0.0338859680756289 no 3211 0.0335299518260335 4659 1941139
SGTC_944 3370-0224 231 µM -1.8361923885892 0.0335176339754902 no 3212 0.033164603993373 4613 4580514
SGTC_2446 5162541 200 µM -1.83690560276218 0.0334645144787335 no 3213 0.0331119160227276 4616 1549321
SGTC_257 daunorubicin 18.5 µM -1.84454683161904 0.0328997405665254 no 3214 0.0325517436817575 4664 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_323 4013-0906 34.3 µM -1.85231979346117 0.0323333142806324 no 3215 0.0319899575351354 4661 2910086
SGTC_26 0302-0163 425.158 µM -1.85422242473826 0.0321958997882212 no 3216 0.0318536725704903 4701 3100915
SGTC_542 3381-0244 89.3 µM -1.85489475998448 0.0321474568714507 no 3217 0.0318056282071216 4649 1112843
SGTC_3006 9075424 71.4286 µM -1.86875024048193 0.031162469127754 no 3218 0.0308287853265495 4614 7465181
SGTC_1016 4226-1401 38 µM -1.87174191830809 0.0309531009254391 no 3219 0.0306211586060617 4651 2901613
SGTC_233 rapamycin 362 pM -1.89340435590996 0.0294715724975249 no 3220 0.0291520583033083 4668 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2330 7979373 200 µM -1.89617423754472 0.0292864523856702 no 3221 0.0289685042995756 4581 1863007
SGTC_2874 9043904 71.43 µM -1.89753875275537 0.0291956130930028 no 3222 0.0288784345942426 4582 4463428
SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.89823297444352 0.029149486871893 no 3223 0.028832699428719 4670 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_167 3672-0051 66.205 µM -1.90512170981447 0.0286950507526409 no 3224 0.0283821259877062 4588 3237971
SGTC_1000 4048-0884 8.67 µM -1.91335030780562 0.0281599637350825 no 3225 0.0278516106939948 4654 13040088
SGTC_1477 0139-0234 16 µM -1.91953418288304 0.0277633298554977 no 3226 0.0274583822699609 4679 620880
SGTC_2556 citropten 84.59 µM -1.92033133209866 0.0277125410457376 no 3227 0.0274080305628163 4636 2775 A potential DNA crosslinker.
SGTC_900 1112-0045 141 µM -1.92511051632949 0.0274096657306023 no 3228 0.027107766797805 4612 56211 YIL048W NEO1
SGTC_44 0929-0055 61.211 µM -1.92706110882962 0.0272868448774616 no 3229 0.0269860073852722 4518 1379590
SGTC_1806 st050005 60.3 µM -1.92888973734453 0.0271721208334122 no 3230 0.0268722760738882 4702 5194765
SGTC_395 anisomycin 6.25 µM -1.94765353265227 0.0260180056566629 no 3231 0.0257282168332191 4680 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2226 7298446 200 µM -1.95325535384135 0.0256815052021735 no 3232 0.0253946724625415 4687 3283010
SGTC_1194 1488-0194 225 µM -1.9536084280951 0.0256604187018184 no 3233 0.0253737715715238 4671 1391452
SGTC_2555 cholic acid 100 µM -1.95597711973149 0.0255193288312482 no 3234 0.025233924740244 4634 6708657 Influences liver metabolism.
SGTC_1873 rapamycin 2 nM -1.95908637055048 0.0253351144947914 no 3235 0.0250513363432499 4643 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1931 st074438 57.1 µM -1.96180130360818 0.0251751746636562 no 3236 0.0248928109331637 4672 2787313
SGTC_1874 staurosporine 7.6 µM -1.9672447199018 0.0248570450878635 no 3237 0.0245775023453874 4667 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1442 4112-3290 3 µM -1.98363752948218 0.0239192984337188 no 3238 0.0236481311510808 4702 704353
SGTC_1638 st008370 60.6 µM -1.9851313563603 0.0238353424647655 no 3239 0.0235649294817106 4641 24207134
SGTC_1547 harmine 94.2 µM -1.98692000597214 0.0237351428935012 no 3240 0.0234656311208983 4604 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.98750147982749 0.0237026452960901 no 3241 0.0234334260394119 4619 5355888
SGTC_1872 amphotericin b 148 nM -1.99944361532907 0.0230434498445079 no 3242 0.0227801884126201 4701 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_341 1486-1430 230 µM -2.00018767850826 0.0230028942679993 no 3243 0.0227400009056819 4661 2054753 YPL210C SRP72
SGTC_2802 7925815 54.55 µM -2.00021059745561 0.0230016460130385 no 3244 0.0227387639823222 4665 1262923
SGTC_226 1,3-diallylurea 8.28947 mM -2.00027486931302 0.0229981458221724 no 3245 0.0227352955669311 4667 74537 YKL182W FAS1
SGTC_218 alverine citrate 93.75 µM -2.00116519365483 0.0229497056443281 no 3246 0.0226872952761356 4718 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_482 fipronil 114 µM -2.00263618601095 0.022869861171668 no 3247 0.0226081764321598 4760 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1238 0333-0287 48.8 µM -2.01611467620104 0.0221490954661617 no 3248 0.0218939928675267 4706 7226
SGTC_1311 1190-0148 100 µM -2.01752053483991 0.0220750331045624 no 3249 0.0218206101377771 4694 1961333
SGTC_2213 7173844 200 µM -2.01760856475064 0.0220704025432911 no 3250 0.0218160220893109 4709 892728
SGTC_1993 st073995 70.8 µM -2.02322986651198 0.0217764031879777 no 3251 0.021524726894691 4675 3098394
SGTC_2211 7117706 200 µM -2.02338519154971 0.0217683267373821 no 3252 0.0215167248689265 4680 822771
SGTC_2229 7354935 190 µM -2.0242276425775 0.0217245657972911 no 3253 0.0214733673174996 4681 318112
SGTC_1841 st054148 70 µM -2.02743012870921 0.0215588909617984 no 3254 0.0213092216648523 4709 675442
SGTC_2602 kawain 100 µM -2.03087727713588 0.0213817534897018 no 3255 0.0211337226796582 4659 5369129
SGTC_2679 rapamycin 1 nM -2.03990878908549 0.0209234804793805 no 3256 0.0206797056002295 4546 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2453 5731132 22.18 µM -2.04328078021483 0.020754525093415 no 3257 0.0205123255421144 4707 1362040
SGTC_2839 9003951 25.97 µM -2.07700005155925 0.0191276292473796 no 3258 0.0189007772309837 4729 2990634
SGTC_2215 7188065 200 µM -2.0806119801923 0.0189599696541797 no 3259 0.0187347182217501 4735 940217
SGTC_877 0771-0151 33.1 µM -2.08209355345863 0.0188915599377938 no 3260 0.0186669626347363 4713 6166523
SGTC_2572 astragaloside iv 100 µM -2.0921368785885 0.018433336484687 no 3261 0.0182131365116816 4653 45006101 An anti-inflammatory agent.
SGTC_1224 0823-0416 294 µM -2.10135380269237 0.0180211808678715 no 3262 0.0178049600331002 4719 3598164
SGTC_1676 st018489 23.4 µM -2.10478581982197 0.0178697309168046 no 3263 0.0176549780336972 4670 3696235
SGTC_3294 9122953 26.2835 µM -2.10576286872559 0.0178268141901767 no 3264 0.0176124778551656 4687 16459826
SGTC_73 0327-0325 16.231 µM -2.10869413133977 0.0176985861131321 no 3265 0.017485495866057 4552 53298
SGTC_280 3448-3607 3.04 µM -2.12807930484153 0.01687023948352 no 3266 0.0166652544318056 4695 626179
SGTC_2510 benzyl isothiocyanate 8.31 µM -2.1326698851994 0.0166790079357044 no 3267 0.0164759079921991 4719 2346 DNA damaging agent; causes G2/M arrest.
SGTC_148 3253-0744 288.01 µM -2.13408304927078 0.0166205138463158 no 3268 0.0164179915871638 4639 6893655
SGTC_1971 st069429 63.5 µM -2.15110636575839 0.0159295626030053 no 3269 0.0157339025888709 4711 1246522 YGL099W LSG1
SGTC_2702 st077768 96.8 µM -2.15156728775597 0.0159112021240848 no 3270 0.0157157254399055 4695 6484119
SGTC_1737 st035557 69.7 µM -2.1546369742174 0.0157893856913403 no 3271 0.0155951266552661 4605 5716916
SGTC_867 0518-0118 155 µM -2.16093841219896 0.0155418260259712 no 3272 0.0153500485912037 4695 6848158
SGTC_754 3474-0146 171 µM -2.17457328003553 0.0150175443550116 no 3273 0.0148310542296644 4728 24762078
SGTC_279 1273-0055 2.93 µM -2.18630959428606 0.0145785098252558 no 3274 0.0143964813429795 4753 2847562
SGTC_1738 st035555 74 µM -2.19655555862318 0.0142043020089131 no 3275 0.0140261015620744 4697 5331140
SGTC_320 4092-0846 5.34 µM -2.20099211215962 0.0140448532678175 no 3276 0.013868291125294 4694 1359356
SGTC_2860 9025725 38.96 µM -2.22808646477186 0.0131041814028043 no 3277 0.0129373748501021 4745 40546248
SGTC_2610 ononetin 44.17 µM -2.23333119244355 0.0129285231882732 no 3278 0.0127635559969929 4696 259632
SGTC_538 2922-0838 53.3 µM -2.23718303637687 0.0128008161531669 no 3279 0.0126371898009067 4743 777039
SGTC_2508 celastrol 40.54 µM -2.25583087408794 0.0121978665832057 no 3280 0.0120406124976263 4701 122724 Celastrol is a natural product and antioxidant.
SGTC_1925 st057770 10.1 µM -2.25746311493693 0.0121462815399226 no 3281 0.0119895758887741 4710 5989122
SGTC_1933 st074711 15.9 µM -2.27015445916921 0.0117515985820468 no 3282 0.0115991065217838 4733 17250958
SGTC_1916 st067606 49.2 µM -2.27111913093869 0.0117220590296784 no 3283 0.0115698835878809 4649 19590279
SGTC_1223 0764-0573 147 µM -2.27239091902857 0.0116832136644269 no 3284 0.0115314548549018 4739 1609797
SGTC_219 mitoxanthrone 164.414 µM -2.28039089247956 0.0114414161311585 no 3285 0.0112922576486001 4729 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_382 3229-0966 23.2 µM -2.28264060499595 0.0113742070950273 no 3286 0.0112257735357704 4754 5722370
SGTC_721 1187-1332 279 µM -2.28437715676983 0.0113225633278645 no 3287 0.0111746874442475 4741 25730
SGTC_1957 st077035 62.4 µM -2.28590581677566 0.0112772708756407 no 3288 0.0111298845434156 4735 705593
SGTC_1852 st056254 31.4 µM -2.29286757333619 0.0110729880140822 no 3289 0.0109278151009663 4737 442583
SGTC_2386 9075165 157.42 µM -2.31237038883609 0.0105177516203315 no 3290 0.0103786403616137 4739 16452277
SGTC_871 0574-0004 149 µM -2.32638456281152 0.0101339025692959 no 3291 0.00999902220739506 4714 9551173
SGTC_1985 st071382 65.5 µM -2.32692807757379 0.0101192651175939 no 3292 0.00998454676518871 4741 6123237
SGTC_2427 5545055 42.75 µM -2.35783734301024 0.0093166289244327 no 3293 0.00919087264619352 4723 5372858
SGTC_1136 pergolide 1.05886 µM -2.35923810494415 0.0092816125431297 no 3294 0.00915625085288545 4702 47811 A dopamine receptor agonist.
SGTC_2344 7990960 76.95 µM -2.38364325318341 0.00868974997427031 no 3295 0.00857110558158591 4723 140813
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -2.39835762313559 0.00834912490996316 no 3296 0.00823438875024891 4741 616764
SGTC_3040 9091894 49.47 µM -2.40773241361382 0.00813827146439242 no 3297 0.00802597073065962 4714 25236966
SGTC_786 4544-0069 423 µM -2.41714343228083 0.00793132392031564 no 3298 0.00782142586002348 4738 748821 YLR208W SEC13
SGTC_2345 9052315 157.45 µM -2.42745923577715 0.00770981009116974 no 3299 0.0076024977324871 4736 6469265
SGTC_1165 k072-0275 30.3 µM -2.42857923149942 0.00768609096503017 no 3300 0.00757905634471906 4750 6153523 YGL055W OLE1
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -2.44328588782342 0.00738054289416864 no 3301 0.00727710143751152 4769 2333 A French combination drug.
SGTC_469 w7 172 µM -2.44672803259879 0.00731059344340584 no 3302 0.00720797865057651 4787 45115570 A P450 inhibitor.
SGTC_1475 4092-1048 11.7 µM -2.45568324272912 0.00713134139150916 no 3303 0.00703085210169822 4756 2881759
SGTC_1123 mangostin 811.285 nM -2.48780753291158 0.00651982185705334 no 3304 0.00642666359691073 4752 5281650 An antioxidant.
SGTC_755 1995-0008 37.3 µM -2.48794904539161 0.00651723395560598 no 3305 0.00642410699194884 4758 689533
SGTC_1376 2910-0861 41.3 µM -2.50755951624171 0.00616727803463632 no 3306 0.00607840534378379 4733 1112859
SGTC_2823 7987624 58.44 µM -2.51079444396961 0.00611117738480086 no 3307 0.00602299085537073 4706 2239440
SGTC_2422 chlorphenesin carbamate 384.24 µM -2.52604948143201 0.005852671013989 no 3308 0.00576766164578835 4713 2724 A muscle relaxant with antifungal properties.
SGTC_2514 salinomycin 42.74 µM -2.58648077847262 0.00492141800180837 no 3309 0.00484807891429499 4762 23682228 A polyether potassium ionophore.
SGTC_1732 st034308 51.822 µM -2.59171294523624 0.00484736576666836 no 3310 0.00477497093923477 4719 830119
SGTC_15 0266-0086 27.098 µM -2.59346883132871 0.0048227377704852 no 3311 0.00475065754627117 4777 1712902 YIL048W NEO1
SGTC_1525 8-methoxypsoralen 92.5 µM -2.60665046681796 0.00464138686114624 no 3312 0.00457163209719852 4763 4114 Related to psoralen; DNA damaging agent.
SGTC_2000 st075254 36.4 µM -2.62366429491261 0.00441632037968239 no 3313 0.0043494739423673 4760 17234175
SGTC_1232 0279-0259 161 µM -2.66011899456169 0.0039666090251999 no 3314 0.0039056524402981 4771 1560000
SGTC_2017 5132927 60.65 µM -2.66078751385359 0.00395875967318359 no 3315 0.00389790687023101 4753 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2974 9094440 9.66 µM -2.68203924761879 0.00371637429294406 no 3316 0.00365874371601049 4747 25236134
SGTC_785 1270-0111 65.3 µM -2.71078107232418 0.00340975003162261 no 3317 0.00335624650475446 4752 6741994
SGTC_2405 ticlatone 3.52 µM -2.72428100738495 0.00327373605660647 no 3318 0.00322208254542169 4676 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -2.72783906189684 0.00323871023484263 no 3319 0.00318753514203685 4782 688803
SGTC_2820 7989630 71.43 µM -2.74077282293797 0.00311421126920664 no 3320 0.00306474356524073 4783 2984098
SGTC_1986 st071812 45 µM -2.74205954834923 0.00310206412583944 no 3321 0.00305276359158125 4759 11838594
SGTC_3187 9109394 49.47 µM -2.75421443930915 0.00298940536186086 no 3322 0.00294166030830958 4781 17098090
SGTC_1326 1431-2094 10.8 µM -2.81513304461276 0.00247841892665521 no 3323 0.00243785220365949 4787 616278
SGTC_1316 1272-0050 65.9 µM -2.8264883854199 0.00239240944811284 no 3324 0.00235307253424024 4789 7340392
SGTC_1327 1436-0082 2.18 µM -2.84430226562661 0.00226291258797593 no 3325 0.00222544011161238 4794 15992205
SGTC_1022 4477-0945 21.3 µM -2.85129214108679 0.00221385926162719 no 3326 0.00217709720493188 4759 4648966
SGTC_2941 9056145 11.23 µM -2.87927773936919 0.0020269689579383 no 3327 0.0019929356955257 4776 2119517
SGTC_1867 st057372 64 µM -2.88094845090232 0.00201627846734392 no 3328 0.00198240239752812 4788 688837
SGTC_1337 1486-1011 40.3 µM -2.88989437502919 0.00195990149139985 no 3329 0.001926856434984 4791 X1337
SGTC_1182 1222-0449 220 µM -2.89672725692087 0.00191780943672545 no 3330 0.00188538711497015 4786 658318
SGTC_2060 5238662 140 µM -2.92889728164834 0.0017304597658337 no 3331 0.001700834075481 4779 790130
SGTC_2614 arthonioic acid 13.39 µM -2.9360028663662 0.00169139342175674 no 3332 0.00166235625172554 4726 6710684
SGTC_2809 7964133 12.99 µM -2.96675913093227 0.00153138916852159 no 3333 0.00150478316032768 4776 1253665
SGTC_2050 5263056 171 µM -2.98023061045725 0.00146575585585749 no 3334 0.00144015727767828 4767 763468 YGL055W OLE1
SGTC_1135 dihydrocapsaicin 536.708 nM -2.9969325938037 0.00138795118473844 no 3335 0.00136355503051367 4770 107982 A Capsaicinoid.
SGTC_2790 5423970 71.43 µM -3.01183743298408 0.00132172342813689 no 3336 0.00129835810442127 4774 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_353 1988-1175 58.3 µM -3.06365796488735 0.00111331729731393 no 3337 0.00109324368495652 4682 2788357
SGTC_2791 5663188 71.43 µM -3.08715039823559 0.00102914814078774 no 3338 0.0010104266169072 4777 54690634
SGTC_1617 st002906 78 µM -3.15596905011161 0.000815042802407361 yes 3339 0.000799829167973307 4787 5150859
SGTC_74 000s-0487 160.283 µM -3.16781462398245 0.000782619913451004 yes 3340 0.000767947102529972 4757 677548
SGTC_2693 st077581 40.7 µM -3.17762385152731 0.000756674289650592 yes 3341 0.000742436275755591 4778 25238761
SGTC_1987 st072290 61.9 µM -3.19283778130901 0.000717996718930149 yes 3342 0.000704410329937924 4798 54697379
SGTC_2408 sulbentine 18.36 µM -3.22360357396029 0.000645292104178061 yes 3343 0.000632942552691219 4740 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_790 1575-0012 79.1 µM -3.32911077333507 0.000444456472302852 yes 3344 0.000435618726446443 4805 378741 YLR208W SEC13
SGTC_1264 0783-0040 158 µM -3.32949852796505 0.000443839322623749 yes 3345 0.000435012620485911 4785 2855798
SGTC_2299 7976368 114.88 µM -3.45098100957567 0.000285197786685176 yes 3346 0.000279276434799051 4794 2979718
SGTC_476 mead acid 10 µM -3.6696356655603 0.000124228306164926 yes 3347 0.000121448202455165 4809 5312531 An omega 9 fatty acid.
SGTC_2302 7771753 200 µM -3.9124212143144 4.6822475196981e-05 yes 3348 4.56876767479103e-05 4789 2203047
SGTC_783 0848-0141 92.7 µM -4.01500201965398 3.04860227934827e-05 yes 3349 2.97226428775323e-05 4799 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_540 1187-0821 17.3 µM -4.0510618379355 2.61552658255608e-05 yes 3350 2.54928647776612e-05 4805 847520
SGTC_541 4513-1321 94 µM -4.81483908449147 7.60706425009549e-07 yes 3351 7.36592766410242e-07 4809 747515
SGTC_1984 st072354 53.1 µM -5.19694905618248 1.04979674463814e-07 yes 3352 1.01292925745865e-07 4807 5762938