SGTCid condition conc unit CWC2|YDL209C.score CWC2|YDL209C.strain.pval CWC2|YDL209C.strain.significant CWC2|YDL209C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2405 ticlatone 3.52 µM 7.12051996460924 1.71846536282431e-10 yes 1 5.37603282707017e-13 5 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1369 1866-0067 208 µM 6.38098496712636 9.21573512400146e-09 yes 2 8.79762908061482e-11 2 3531355 SGTC_464 bw-b 70c 158 µM 6.24201429337706 1.85975795193725e-08 yes 3 2.15985733361698e-10 1 5353454 SGTC_2725 haloperidol 53.21 µM 6.14165695719824 3.06000582773193e-08 yes 4 4.08325374186468e-10 7 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2701 st077767 14.721 µM 5.79178133328301 1.63649913713976e-07 yes 5 3.4821889464665e-09 3 5721188 SGTC_2292 7671323 168.05 µM 5.65952969889355 3.01130909301669e-07 yes 6 7.58941906117736e-09 4 937504 SGTC_2028 5153890 36.43 µM 5.59013540194003 4.12514018331634e-07 yes 7 1.13446308506633e-08 4 2830968 YPR165W RHO1 SGTC_774 k060-0086 136 µM 5.07257123066226 3.84995089124115e-06 yes 8 1.96238075090225e-07 1 5911235 SGTC_2413 inermin 26.06 µM 4.78987430477013 1.19843194457113e-05 yes 9 8.34429096364531e-07 12 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2384 9036245 200 µM 4.75680287599458 1.36338670182665e-05 yes 10 9.83415286944225e-07 1 6462766 SGTC_907 3448-6986 75.5 µM 4.70080026075776 1.69298806132375e-05 yes 11 1.29571950779109e-06 3 590582 SGTC_2310 7668677 200 µM 4.65006240063753 2.05577726460152e-05 yes 12 1.65917306790168e-06 3 2197143 SGTC_2642 cholecalciferol 100 µM 4.57818480662341 2.69781461046042e-05 yes 13 2.34514116247911e-06 1 9821465 A vitamin D precursor, similar to steriods. SGTC_160 3453-0671 289.699 µM 4.52617303579428 3.27633737852923e-05 yes 14 3.00307039397284e-06 4 5322268 SGTC_2921 7974240 10.71 µM 4.48766830529405 3.7782720810834e-05 yes 15 3.60034609590141e-06 12 2979074 YDR527W RBA50 SGTC_1342 1486-1464 234 µM 4.42950790815747 4.67623117189764e-05 yes 16 4.72241749726357e-06 2 3253938 SGTC_2823 7987624 58.44 µM 4.39128333575817 5.37237056095778e-05 yes 17 5.63417933550454e-06 8 2239440 SGTC_2924 9010168 62.78 µM 4.36506777098758 5.90513911087235e-05 yes 18 6.35416761868111e-06 3 2993929 SGTC_1836 st055642 81 µM 4.33368078161809 6.60853494321921e-05 yes 19 7.33183791235381e-06 3 8571 SGTC_3027 9089541 49.47 µM 4.25871061312126 8.62125488565191e-05 yes 20 1.02804720978459e-05 13 9943819 SGTC_909 3448-9333 149 µM 4.23412701944544 9.39812977521015e-05 yes 21 1.14720620406921e-05 1 3344074 SGTC_600 1495-0418 41.6 µM 4.20398371488114 0.000104405408454546 yes 22 1.31128907366058e-05 4 5377768 SGTC_3112 9123419 49.47 µM 4.19593570423904 0.000107366918315082 yes 23 1.35873667595374e-05 6 17015854 SGTC_1373 2887-0003 58.5 µM 4.13024397783396 0.000134663776480862 yes 24 1.81189227013573e-05 9 776948 SGTC_2468 5987765 72.9 µM 4.03143964749934 0.000188204043326229 yes 25 2.77181164101989e-05 4 26772094 SGTC_2897 9048598 12.99 µM 3.9783842702401 0.000224600332884582 yes 26 3.46925847275676e-05 1 6467404 SGTC_2698 st077697 67.5 µM 3.87226320700042 0.000317909535474221 yes 27 5.39147079556236e-05 7 3154499 SGTC_777 1315-0167 517 µM 3.84821970398677 0.000343553369860993 yes 28 5.9489663408589e-05 3 4221767 SGTC_1321 1326-2144 215 µM 3.81397615523026 0.000383408001205979 yes 29 6.83743340747937e-05 4 3513030 SGTC_1967 st070177 51.4 µM 3.77829165235866 0.000429475785149774 yes 30 7.89539415790784e-05 7 5729214 SGTC_2714 st079313 56.9 µM 3.76852617040866 0.000442949067635437 yes 31 8.21071354317395e-05 6 2939799 SGTC_1133 3473-0247 50 µM 3.71007794883932 0.000532126791493106 yes 32 0.000103597721477683 52 711311 SGTC_2673 kobusone 100 µM 3.68482660854657 0.000575568647910895 yes 33 0.000114429192895944 1 6710676 An epoxy ketone and protein crosslinker. SGTC_3202 9113761 49.47 µM 3.64846987497264 0.000643894285867297 yes 34 0.000131903414548987 13 4798415 SGTC_229 benomyl 22.8748 µM 3.6219823250903 0.000698304527443116 yes 35 0.000146177050434563 16 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2022 5136654 200 µM 3.61016698687377 0.000723916925712962 yes 36 0.000152999970654002 8 1713771 SGTC_2597 laccaic acid a 100 µM 3.55463551607943 0.000856298109649128 yes 37 0.000189251699373867 8 5491415 A textile dye. SGTC_62 0180-0423 3.232 µM 3.53383317085589 0.000911375397500699 yes 38 0.000204789757652148 17 30102 YGL099W LSG1 SGTC_2289 7946404 165.07 µM 3.52374018854208 0.000939254607238898 yes 39 0.000212750625349703 25 1246120 YPR165W RHO1 SGTC_481 bay k-8644 50 µM 3.49038323255002 0.00103706124210174 no 40 0.000241164169314402 9 2303 A calcium channel antagonist. SGTC_454 lyso-paf C-16 6.67 µM 3.48559356106963 0.00105184809227108 no 41 0.000245523234884213 6 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1629 st005085 44.9 µM 3.4217729723795 0.00126821767329286 no 42 0.00031107119214728 19 24207091 SGTC_1775 st081588 35.1725 µM 3.41673777222275 0.00128691246446566 no 43 0.000316881465787085 16 1426443 YGL099W LSG1 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 3.4164776089061 0.00128788521630406 no 44 0.000317184402009123 21 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2594 a-mangostin 100 µM 3.3558069333214 0.00153399370793488 no 45 0.000395668956325026 14 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2665 lovastatin 100 µM 3.34771396125869 0.00156988232195163 no 46 0.000407405315741245 5 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_679 0422-0091 41.4 µM 3.32864731341821 0.0016574794689228 no 47 0.000436344195847654 20 627384 YHR062C RPP1 SGTC_234 nsc-17383 10.7 µM 3.31770674179643 0.00170973107611091 no 48 0.000453798601734925 10 408974 SGTC_248 streptozotocin 5.23457 mM 3.30411640686694 0.00177672443967565 no 49 0.000476381311441912 22 5300 DNA alkylating agent. SGTC_2920 7982904 15.77 µM 3.30061835233567 0.00179435020608765 no 50 0.00048236007394322 19 6456808 SGTC_2731 amoxapine 43.43 µM 3.2861153561903 0.00186913628010776 no 51 0.000507897004888386 5 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2119 5528445 120.635 µM 3.28510537442959 0.00187444840821008 no 52 0.00050972118694383 8 791935 SGTC_2652 actinonin 100 µM 3.2660976749884 0.001977015258591 no 53 0.000545203156325406 7 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_446 go6976 132 µM 3.26249167354493 0.00199703920187513 no 54 0.000552187085253225 7 3501 A protein kinase C inhibitor. SGTC_436 n,n-dimethylsphingosine 3.3 µM 3.2474268407248 0.00208270020938696 no 55 0.000582267992677305 9 5282309 SGTC_579 4491-1009 110 µM 3.24506367498185 0.00209643599544847 no 56 0.000587121817244619 15 1271041 SGTC_2056 5235370 200 µM 3.19539760965283 0.0024047977617216 no 57 0.00069819160099996 13 5511916 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 3.18801054548255 0.00245401413829004 no 58 0.000716276559308052 15 6710655 SGTC_2312 7706453 155.7 µM 3.14825935854617 0.00273484037882375 no 59 0.00082122947095927 23 976098 SGTC_3301 9125354 19.7965 µM 3.13073816696089 0.00286758615358912 no 60 0.000871837734935928 8 41905162 SGTC_2951 9072950 58.06 µM 3.11961397274987 0.00295485424699102 no 61 0.000905440945295512 15 16488155 SGTC_1368 1852-0141 284 µM 3.08775074403115 0.00321821989500439 no 62 0.00100838775473104 11 2838987 SGTC_2319 6033012 152.6 µM 3.07762725444803 0.00330621141907599 no 63 0.0010432786441396 10 847246 SGTC_1879 gemcitabine 100 µM 3.07592963936634 0.00332117676785601 no 64 0.001049236789966 6 60750 A nucleoside analog which inhibits DNA replication. SGTC_1608 st001473 40.5 µM 3.07423154778456 0.0033362072194456 no 65 0.00105522781459909 18 7292267 SGTC_2537 larixol 68.93 µM 2.98890210634715 0.00417489124167873 no 66 0.0013999091027478 19 6708759 SGTC_1080 nisoldipine 24.4 µM 2.98354759815247 0.00423332413555884 no 67 0.00142463857224085 18 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1176 0848-0131 83.3 µM 2.97498549199199 0.00432828180933249 no 68 0.00146501202410256 11 6769040 SGTC_3281 9140613 49.47 µM 2.95372805841033 0.0045723170172081 no 69 0.0015698026652529 9 16013766 SGTC_2779 methotrexate 400 µM 2.94778953084784 0.00464265108854908 no 70 0.00160027443143765 32 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_42 0133-0086 60.653 µM 2.94579540792698 0.00466648446489849 no 71 0.00161062694560619 29 162923 Model of phenazepam hydroxylation. SGTC_2529 gangaleoidin 93.61 µM 2.92972704215574 0.00486254864598944 no 72 0.00169629935281668 11 4565183 SGTC_2122 5258151 111.688 µM 2.91821115181807 0.00500754703912283 no 73 0.00176022934877944 14 2173356 SGTC_415 dibenzyl ketone 100 µM 2.90344125391432 0.00519914766509408 no 74 0.00184543103816652 11 7593 SGTC_1065 prochlorperazine maleate 2.48 µM 2.88366166898814 0.00546594327175444 no 75 0.00196540410033535 17 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2269 7935389 174.42 µM 2.88247889061419 0.00548227593288282 no 76 0.00197279785942352 18 97605 SGTC_1645 Cervolide 78 µM 2.86896910805558 0.00567192841665809 no 77 0.00205906008799836 12 23173 A fragrance. SGTC_668 1682-0499 62.6 µM 2.83808476093613 0.00612752221368811 no 78 0.0022692564380881 15 682214 SGTC_734 2023-0417 80 µM 2.79787075061257 0.00676918116587353 no 79 0.00257203462889131 30 3935732 SGTC_1028 k015-0029 4.8 µM 2.76984060632043 0.00725086718475011 no 80 0.00280418655019483 14 4588309 SGTC_1077 5-fluorocytosine 377 nM 2.7475511761521 0.00765522162234979 no 81 0.0030021068951064 33 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2026 5148700 152 µM 2.73079840593443 0.00797207354851406 no 82 0.00315905530517632 18 79838 SGTC_633 0437-0093 97.7 µM 2.7285229403132 0.00801598793327266 no 83 0.00318093325216073 21 2831118 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 2.68981535831751 0.00879626741807369 no 84 0.00357457814292417 22 688801 SGTC_2486 5283202 22.39 µM 2.68823531870577 0.00882948625485071 no 85 0.00359153782145766 16 1377751 SGTC_927 2425-1185 123 µM 2.6695983740028 0.00922968516779134 no 86 0.00379710117627518 23 730375 SGTC_1740 st038286 13.222 µM 2.66932205243107 0.00923573626393768 no 87 0.00380022675004842 32 716786 SGTC_296 1222-0039 74.9 µM 2.6538686239662 0.00957972103727197 no 88 0.00397874008370298 12 5984176 SGTC_1674 st016616 23.6 µM 2.62469392758219 0.0102597573221345 no 89 0.004336344448904 23 625830 SGTC_708 3448-5400 146 µM 2.59191342057012 0.0110737182964495 no 90 0.00477218939875123 56 3462195 SGTC_2397 5161689 200 µM 2.58953536353429 0.011134894042781 no 91 0.00480527755617661 22 2259942 SGTC_1782 st039423 80.636 µM 2.58740662905246 0.0111899050079209 no 92 0.00483506998920025 13 2068169 SGTC_3279 9140807 49.47 µM 2.5767889659313 0.0114678301509033 no 93 0.00498614066736945 12 45595718 SGTC_2490 carminic acid 95.39 µM 2.57491053730709 0.0115176186852674 no 94 0.00501330085448174 29 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3143 9086658 49.47 µM 2.57113352714421 0.011618298429583 no 95 0.00506831177013195 40 25236626 SGTC_1025 k007-0731 70 µM 2.56992558675547 0.0116506580677808 no 96 0.00508601810957981 20 6256118 SGTC_1991 st073000 8.92 µM 2.56917518716655 0.0116707999763104 no 97 0.00509704539674618 44 4301969 YIL048W NEO1 SGTC_3041 9091929 49.47 µM 2.56186123243024 0.011868706419738 no 98 0.00520564540417627 20 25236887 SGTC_2654 protoveratrine a 100 µM 2.56057515067748 0.0119038055232678 no 99 0.0052249529889413 21 5702278 A heart drug and vasodilator. SGTC_1886 st057356 49.9 µM 2.56002128750349 0.0119189489976458 no 100 0.0052332875906558 24 24207747 SGTC_853 0419-0306 21 µM 2.50165026384407 0.0136115005697557 no 101 0.00618079860641388 42 762713 SGTC_3159 9100096 49.47 µM 2.49611169037705 0.0137823824083386 no 102 0.00627815295016171 31 25236875 SGTC_1067 clotrimazole 1.36 µM 2.48684431890623 0.0140724482285315 no 103 0.00644408922761488 46 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1259 0671-0132 43 µM 2.48344244192895 0.0141802382531305 no 104 0.00650596803561466 29 X1259 SGTC_2443 5493264 126.67 µM 2.48151899611427 0.0142414977351553 no 105 0.00654118685403998 24 5340055 SGTC_2727 riluzole 51.77 µM 2.47947449325382 0.014306862544359 no 106 0.00657880702066247 31 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1638 st008370 60.6 µM 2.47106315882393 0.0145785065817086 no 107 0.0067356012198497 37 24207134 SGTC_1047 2043-3044 82 µM 2.46447888903903 0.0147942316313466 no 108 0.00686063231467943 37 669592 SGTC_3289 9119912 71.43 µM 2.44847116460408 0.0153301858622754 no 109 0.00717319564304185 24 17014829 SGTC_2399 5884133 200 µM 2.4443984162019 0.0154691769252997 no 110 0.00725469675419349 42 722445 SGTC_769 0302-0231 76 µM 2.44426309516217 0.0154738135471156 no 111 0.00725741866755938 58 571869 YER009W NTF2 SGTC_2018 5133068 143 µM 2.44365174223174 0.0154947757336194 no 112 0.00726972694540993 37 785362 SGTC_526 4469-0568 170 µM 2.44201061140389 0.0155511677224711 no 113 0.00730285865301041 32 2901964 SGTC_1838 st055369 84.5 µM 2.43852772136208 0.0156714294208013 no 114 0.00737361377071091 20 676036 SGTC_2678 equilin 100 µM 2.43290159294855 0.0158673810238451 no 115 0.00748918555440214 18 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_3295 9122362 53.5725 µM 2.42798335900415 0.0160403948715206 no 116 0.00759151995504746 35 4730473 SGTC_54 0159-0055 9 µM 2.4227314834327 0.0162269282246446 no 117 0.00770215404964859 30 3319099 SGTC_903 1134-0042 114 µM 2.41695003248395 0.0164344164821023 no 118 0.00782558273487305 26 701009 SGTC_277 nystatin 15.5 µM 2.41491727829042 0.0165079069614892 no 119 0.0078693918316151 21 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_381 3461-2219 42.7 µM 2.39926703877092 0.0170831893896443 no 120 0.00821396469131775 29 2883159 SGTC_1849 st056239 19.2 µM 2.3850643974801 0.0176200057930607 no 121 0.00853806594505568 19 5393181 SGTC_670 4204-0025 119 µM 2.38380311821835 0.0176683668635647 no 122 0.00856738335033757 24 719039 SGTC_1776 st049249 45.9 µM 2.36890821544276 0.0182481002012522 no 123 0.00892034013767314 45 1822314 SGTC_979 1426-2828 121 µM 2.36868821309964 0.0182567830890676 no 124 0.00892564751171907 31 747872 SGTC_819 1013-0258 27.7 µM 2.36831677573658 0.0182714506900508 no 125 0.00893461440889278 26 5753198 SGTC_2328 6201408 200 µM 2.36565109149878 0.0183770101356098 no 126 0.00899919877765048 49 2890418 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 2.36115255333697 0.0185563275090492 no 127 0.0091091172594355 36 5355888 SGTC_2059 5238311 157 µM 2.34571331691372 0.0191831273161592 no 128 0.00949535404745386 33 703021 SGTC_2596 sinensetin 100 µM 2.34457844583882 0.0192299024537675 no 129 0.00952430147781671 40 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2813 7971799 71.43 µM 2.33961637006212 0.0194355608468358 no 130 0.00965177840307612 37 2234054 SGTC_141 0443-0274 32.331 µM 2.33527419291784 0.0196170569421323 no 131 0.00976455072082646 29 1627241 SGTC_3240 9133527 49.47 µM 2.33305941606548 0.0197101840173656 no 132 0.00982251355261671 21 17617455 SGTC_2139 5578692 56.4705 µM 2.31983275376148 0.020274187322155 no 133 0.0101749632393422 50 650991 YMR113W FOL3 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 2.31334513244551 0.0205557928228054 no 134 0.0103518355716855 35 689007 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 2.31115937407256 0.020651412377932 no 135 0.0104120267149373 31 6312947 SGTC_854 0422-0053 192 µM 2.29339164298649 0.0214427582814265 no 136 0.0109127336675603 38 3596728 SGTC_1895 st058434 18.3 µM 2.28661055096347 0.0217514628841755 no 137 0.011109282422949 38 5393175 SGTC_1963 st076565 50.3 µM 2.2815941552187 0.021982239497444 no 138 0.0112566560561422 37 4914280 SGTC_1911 st060208 74.3 µM 2.26265648996337 0.0228721741510371 no 139 0.0118284364633263 35 688783 SGTC_1628 st004252 77.7 µM 2.26253133164469 0.0228781551949748 no 140 0.011832297653041 35 692968 SGTC_3154 9100113 49.47 µM 2.26245741408083 0.0228816881735125 no 141 0.0118345785563314 43 25237525 SGTC_695 3505-6186 243 µM 2.25725038621373 0.0231317235280638 no 142 0.0119962168019387 55 1819379 SGTC_1980 st071811 45.7 µM 2.25321797721988 0.0233269321246286 no 143 0.0121227042235788 31 4974850 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 2.25267580651112 0.0233532839998855 no 144 0.012139798737361 22 6708561 SGTC_47 0149-0135 24.25 µM 2.23356099362663 0.0242984864901587 no 145 0.0127559864345519 39 5239155 SGTC_2151 5563267 85.4165 µM 2.22223510378247 0.0248735453464174 no 146 0.0131337106399275 51 5310824 SGTC_2030 5175110 200 µM 2.22051359345255 0.0249619443927199 no 147 0.0131919619881475 28 2831986 SGTC_1982 st072467 71.9 µM 2.21795275792872 0.0250939297934949 no 148 0.0132790268566644 42 3163533 SGTC_157 1348-1695 65.819 µM 2.21030809617973 0.0254914195516178 no 149 0.0135418935588267 72 5380510 SGTC_1292 0kpi-0043 232 µM 2.20471798676867 0.0257854074945206 no 150 0.0137369450798903 34 3333905 SGTC_3145 9085516 49.47 µM 2.20100054196434 0.0259824773466019 no 151 0.0138679927363141 48 25236195 SGTC_2699 st077704 54.6 µM 2.18469391699948 0.0268618720575673 no 152 0.014455648253152 33 645852 SGTC_2753 fluvastatin 17.09 µM 2.18202177583362 0.0270083203333915 no 153 0.0145539628205645 51 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2612 dictamnine 15.46 µM 2.17737220613651 0.0272647311697699 no 154 0.0147264038492687 75 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1249 0481-0015 10.2 µM 2.17659437078284 0.0273078242647505 no 155 0.0147554227775394 48 4227577 SGTC_153 4077-0274 519.67 µM 2.16433684288709 0.0279944422391199 no 156 0.0152192535504013 45 3121976 SGTC_2040 5100729 123 µM 2.15971152835255 0.0282572431610205 no 157 0.0153975040937612 47 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1840 st055363 71 µM 2.1575731808314 0.028379432034192 no 158 0.0154805158616786 28 676033 SGTC_1901 st060216 58.6 µM 2.15044153085977 0.0287901293801051 no 159 0.0157601531136989 42 688792 SGTC_1392 3455-1037 33.9 µM 2.14824142739751 0.0289178218458432 no 160 0.0158472906255155 42 981132 SGTC_2268 7933382 153.85 µM 2.13476649303806 0.0297102071242016 no 161 0.0163900442656071 51 935025 YOR257W CDC31 SGTC_1928 4'-methoxychalcone 40.3 µM 2.13310771005437 0.029808984658016 no 162 0.0164579457277196 41 641818 SGTC_361 000s-0510 1.45 µM 2.13298933077435 0.0298160443334562 no 163 0.0164628007183945 45 660 SGTC_2305 7443522 69.23 µM 2.128269035209 0.0300986765431588 no 164 0.0166573919463768 45 5415886 SGTC_1718 roemerine 11.9335 µM 2.12538009941348 0.0302727474888858 no 165 0.0167774547294726 58 235224 An aporphine alkaloid with mutagenic activity. SGTC_3053 9095903 49.47 µM 2.1182806005444 0.0307040700891732 no 166 0.0170756552904084 42 17174018 SGTC_1989 st071868 50.2 µM 2.11811654643382 0.0307140968652822 no 167 0.0170825992710411 47 16414057 SGTC_114 0364-0001 490.298 µM 2.11492433646037 0.0309097408763878 no 168 0.0172181983105565 47 4003655 SGTC_770 0389-1121 67.2 µM 2.11484097339892 0.0309148638153223 no 169 0.0172217517018758 50 6753108 SGTC_2936 9038235 15.59 µM 2.10919109978244 0.0312637087284752 no 170 0.0174640449242207 59 4749415 SGTC_764 1951-2361 146 µM 2.10782392267129 0.0313486109454479 no 171 0.0175231113790429 56 5438930 SGTC_1445 4239-0156 97.7 µM 2.10517596013276 0.0315135926666216 no 172 0.0176379970237004 38 4008346 SGTC_2658 polymyxin b sulfate 77.05 µM 2.09420362626887 0.0322048920710237 no 173 0.0181209224439324 58 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1936 st074407 74.3 µM 2.08890802607435 0.0325429870327761 no 174 0.0183580016114997 58 809813 SGTC_2470 5664817 21.68 µM 2.08504289055757 0.0327915985516851 no 175 0.0185327037217989 36 2859561 SGTC_1789 tunicamycin 25 nM 2.07666847460139 0.0333356275348665 no 176 0.0189160840916418 64 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2483 5729050 27.16 µM 2.0664815449766 0.0340074007001804 no 177 0.0193915166106648 58 2865180 SGTC_3298 9116858 71.43 µM 2.06410116882231 0.0341659679327103 no 178 0.0195040625902412 55 2506942 SGTC_2373 9071805 200 µM 2.0627543528957 0.0342559541323484 no 179 0.0195679864806683 40 10149009 SGTC_981 1488-1094 54.9 µM 2.0623510953183 0.0342829352615634 no 180 0.0195871608628478 28 3449522 SGTC_1479 0549-0158 134 µM 2.05003078935045 0.0351157164166674 no 181 0.020180713178555 46 5440202 SGTC_1947 st076332 61.6 µM 2.03897956688265 0.0358767692725598 no 182 0.0207260334458726 43 24208416 SGTC_2207 7258803 200 µM 2.02950833193908 0.036539720009023 no 183 0.0212032706052429 38 3666799 SGTC_3348 9149464 3.537 µM 2.0252036596188 0.0368443265539554 no 184 0.0214232280289913 29 1951442 SGTC_507 nimesulide 162 µM 2.02173130637296 0.0370915468827512 no 185 0.0216020589002587 42 4495 A COX2 inhibitor. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 2.02101871014293 0.0371424487193147 no 186 0.0216389141485945 43 6708784 An antioxidant flavonoid SGTC_1282 0886-0010 32.4 µM 2.02020184184289 0.0372008690798902 no 187 0.0216812276615895 72 2836211 YNL267W PIK1 SGTC_2382 9035899 200 µM 2.01302832156512 0.0377171324079312 no 188 0.02205582498122 52 6462679 SGTC_3282 9108498 15.4605 µM 1.98615328457058 0.0397035028624076 no 189 0.0235081531010169 54 16459645 SGTC_2496 diffractaic acid 79.83 µM 1.9839047184001 0.0398734834397581 no 190 0.0236332314149214 59 94870 An apoptosis inducer which activates caspases. SGTC_2798 7813637 45.45 µM 1.98195289713222 0.0400215107007652 no 191 0.0237422563701484 73 956368 SGTC_1289 0976-0073 69.1 µM 1.9819293751723 0.0400232973393908 no 192 0.0237435728357656 49 3391136 SGTC_247 mechlorethamine 29.705 µM 1.97832441823515 0.0402978832306995 no 193 0.0239460600792125 32 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2735 sertaconazole 140 nM 1.97335134443574 0.0406791862633454 no 194 0.0242277734648752 48 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1164 k060-0068 93.7 µM 1.97237863094513 0.0407541089128879 no 195 0.0242831996994536 55 5963676 SGTC_181 1447-1644 8.07 µM 1.96953721370502 0.0409736087634056 no 196 0.0244457167798382 69 534600 SGTC_2172 5754775 163.918 µM 1.96261309840767 0.0415125145108507 no 197 0.0248455737862734 71 2263357 SGTC_1206 3978-0017 132 µM 1.9587960513532 0.0418120432506639 no 198 0.0250683381078849 65 3873677 SGTC_96 0929-0093 37.281 µM 1.95644647830967 0.0419972859414703 no 199 0.0252062907588104 63 6991579 SGTC_1841 st054148 70 µM 1.95309499813705 0.0422626691065856 no 200 0.0254041697795191 50 675442 SGTC_1112 tnp00069 1.16933 µM 1.95059341889931 0.0424616368437664 no 201 0.0255527153523282 44 145826 SGTC_479 n-linoleoylglycine 10 µM 1.94601218200015 0.0428279777349748 no 202 0.0258266381528055 53 6433346 An anti-infammatory. SGTC_1668 st014914 51.6 µM 1.94531150922091 0.0428842319422301 no 203 0.0258687488796107 58 2839556 SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.94488458426172 0.0429185373006291 no 204 0.025894435404741 76 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_754 3474-0146 171 µM 1.94193209719159 0.0431563904364847 no 205 0.0260726605576126 51 24762078 SGTC_2682 pyrogallin 40.03 µM 1.9303311672925 0.0441012935365201 no 206 0.0267829088159324 54 822798 An ATP competetive kinase inhibitor. SGTC_2235 salicylic acid 500 µM 1.92577896937401 0.0444766000971874 no 207 0.0270659892549733 43 338 A COX inhibitor and kinase inhibitor. SGTC_293 4049-0273 38.5 µM 1.91589486838258 0.0453003563774434 no 208 0.0276892394064409 57 1380311 SGTC_1446 4239-0190 62 µM 1.91258226817184 0.045579163810937 no 209 0.0279007757369028 64 1340085 SGTC_405 ebelactone b 50 µM 1.90895637349674 0.0458859197048688 no 210 0.0281338598908428 34 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2943 9068529 45.32 µM 1.90365299165049 0.0463375788076675 no 211 0.0284776962219357 85 3270634 SGTC_38 0929-0051 58.268 µM 1.9019153885482 0.0464863345825798 no 212 0.0285911085246041 51 1379719 SGTC_1199 1638-0010 4.46 µM 1.90139490592373 0.0465309674985218 no 213 0.0286251531389788 53 3111136 SGTC_396 dithiazanine 1.25 µM 1.89981703369228 0.0466664848888228 no 214 0.0287285673863031 39 10578 An antihelmenthic. SGTC_2474 5321570 43.32 µM 1.89763025960966 0.0468548218973745 no 215 0.028872402695352 48 2841384 SGTC_2694 st077685 81.9 µM 1.89575695353734 0.0470166457187163 no 216 0.0289960951932436 51 2838096 SGTC_1182 1222-0449 220 µM 1.8957248945188 0.0470194190029481 no 217 0.0289982158443662 39 658318 SGTC_3163 9099914 49.47 µM 1.89276831199108 0.0472757442723178 no 218 0.0291943436745308 41 16268368 SGTC_835 0312-0010 67.2 µM 1.89152458212721 0.0473839053651792 no 219 0.0292771763523366 65 1626196 SGTC_3241 9133421 49.47 µM 1.88600627826971 0.0478661990044748 no 220 0.0296470543144497 31 17018221 SGTC_1738 st035555 74 µM 1.88272600539818 0.0481547485669749 no 221 0.029868754648337 67 5331140 SGTC_2308 7584454 197.62 µM 1.87771729474533 0.0485980236649198 no 222 0.0302099247539714 77 893577 SGTC_1897 st060201 15 µM 1.87767905976752 0.0486014199968557 no 223 0.0302125415141793 53 611878 SGTC_2179 6298986 200 µM 1.87686351871617 0.048673907978851 no 224 0.0302684010108372 57 738374 SGTC_1859 st055998 20 µM 1.87654200058564 0.0487025093135306 no 225 0.0302904465172268 65 676301 SGTC_2446 5162541 200 µM 1.87262404447624 0.0490521198611321 no 226 0.0305601593246681 48 1549321 SGTC_3263 9137018 49.47 µM 1.86888941825877 0.0493872348194059 no 227 0.030819100409059 76 43844957 SGTC_1521 st012942 49.4 µM 1.86378924048048 0.0498478327826331 no 228 0.0311756536558582 61 24207259 SGTC_1709 st033179 39.1045 µM 1.85896881010262 0.050286310168673 no 229 0.031515779748066 50 573381 SGTC_2159 5658611 73.75 µM 1.85335315242833 0.0508009938202933 no 230 0.0319158786911155 61 793844 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 1.85218476136715 0.0509086039938783 no 231 0.0319996481192354 69 6708739 YPR165W RHO1 SGTC_2330 7979373 200 µM 1.84997970682016 0.0511121864249616 no 232 0.0321582372485208 69 1863007 SGTC_745 0469-0705 296 µM 1.84538879220005 0.0515381226152377 no 233 0.0324905011677578 94 3486736 SGTC_1495 4469-0029 237 µM 1.84376311861152 0.0516896243993924 no 234 0.0326088349185482 55 793680 SGTC_2424 5537928 59.2 µM 1.84365897392458 0.0516993420338549 no 235 0.0326164277715452 69 5382802 SGTC_2867 9039098 71.43 µM 1.83867256197536 0.0521663208662364 no 236 0.0329816807233011 67 6463460 SGTC_2933 9026794 32.47 µM 1.83203472928559 0.0527931468375225 no 237 0.0334731232999283 55 17586027 SGTC_450 aminopyrene 156 nM 1.82475029467381 0.0534878941070782 no 238 0.0340193598718772 61 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2775 cyproheptadine 69.59 µM 1.82415548043893 0.0535449424746693 no 239 0.0340642849637719 63 2913 A selective serotonin reuptake inhibitor. SGTC_971 1315-0384 26.7 µM 1.80449174924153 0.0554581647281141 no 240 0.0355771257238496 68 6769120 SGTC_2117 5521686 200 µM 1.79921477353082 0.0559806787586098 no 241 0.0359923566924633 63 803312 SGTC_1673 st016611 27.3 µM 1.79384805848476 0.0565160535414254 no 242 0.0364187119142124 76 5226799 SGTC_1002 4049-0206 172 µM 1.7907654190815 0.0568253921597032 no 243 0.0366654733635834 77 4662749 SGTC_3097 9117246 49.47 µM 1.78977003604539 0.0569255617895204 no 244 0.0367454440312798 58 16423892 SGTC_3167 9103034 49.47 µM 1.78772867398532 0.0571314276758367 no 245 0.0369098966113717 57 5127859 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.78138579516041 0.0577748309204869 no 246 0.0374247235923511 72 5106787 A p450 inhibitor. SGTC_900 1112-0045 141 µM 1.75894003387578 0.0600975066365849 no 247 0.0392938472126957 53 56211 YIL048W NEO1 SGTC_1614 st002383 48.6 µM 1.75503252562187 0.0605092242266811 no 248 0.0396268722171242 45 1947235 SGTC_1460 k062-0059 9.15 µM 1.75472924448257 0.0605412717388516 no 249 0.0396528156430722 59 1373085 SGTC_2781 5567276 71.43 µM 1.75183010760353 0.0608482921384604 no 250 0.0399015127519163 86 2853274 SGTC_3078 9116413 49.47 µM 1.74974313630251 0.061070056336873 no 251 0.0400813233563698 75 17177322 SGTC_3094 9117742 49.47 µM 1.74865735522265 0.0611856823671258 no 252 0.040175132817357 80 17149698 SGTC_1565 sinapyl alcohol 95.1 µM 1.74277052454787 0.0618155581995507 no 253 0.0406868534769361 68 5280507 A phenol propionate derived from cinnamic acid. SGTC_1676 st018489 23.4 µM 1.7426658421626 0.0618268045781661 no 254 0.0406960007791715 59 3696235 SGTC_947 3447-0010 211 µM 1.74152109919522 0.0619498923930104 no 255 0.0407961390716844 81 748350 SGTC_150 3970-0969 77.2 µM 1.73519308571022 0.0626337618884244 no 256 0.0413533053890625 116 6615640 SGTC_421 streptovitacin 30 mM 1.73452334144002 0.0627064842752828 no 257 0.0414126339572534 62 91467 include heat shock SGTC_665 3914-0008 307 µM 1.72895572218208 0.0633135791737104 no 258 0.041908509991659 53 1069549 SGTC_1530 rhein 70.4 µM 1.72788539020043 0.0634308111579633 no 259 0.0420043870659377 67 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2720 fluspirilene 36.88 µM 1.72321676167703 0.0639441363217865 no 260 0.0424246668467721 59 3396 An atypical antipsychotic. SGTC_834 0312-0008 75.7 µM 1.72146542341903 0.0641375306174875 no 261 0.0425832006423803 75 6385573 YIL048W NEO1 SGTC_2638 epoxomicin 18 µM 1.71848659863596 0.0644675160802732 no 262 0.0428539483949796 58 9915668 A protesome inhibitor. SGTC_2265 7929201 200 µM 1.71157317744041 0.0652384468313608 no 263 0.0434876774319402 78 1265108 SGTC_303 1348-1668 34.2 µM 1.7095633438619 0.0654639045294979 no 264 0.0436733244474605 67 5380509 SGTC_2098 5376439 882.5 nM 1.70464717298632 0.0660179339871484 no 265 0.0441301238918087 64 2844116 SGTC_1031 k035-0009 16 µM 1.69874730811052 0.0666876092085482 no 266 0.0446834027807168 63 5180959 SGTC_2041 5107442 45.335 µM 1.69618643918902 0.0669799165167122 no 267 0.0449252888892943 103 793005 SGTC_3196 9111891 49.47 µM 1.69527707164792 0.0670839532918163 no 268 0.045011436117323 83 18891510 SGTC_756 0508-1999 28.3 µM 1.69450398049169 0.0671724975231224 no 269 0.0450847779779826 89 6753853 SGTC_1752 st044819 83.042 µM 1.69444675480464 0.0671790553270225 no 270 0.045090210703545 79 441209 YML126C ERG13 SGTC_1115 galangin 695.678 nM 1.69318405601877 0.067323880877731 no 271 0.0452102192403227 79 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2162 5663267 200 µM 1.68457459376183 0.0683177864939499 no 272 0.0460353382584715 86 6456493 SGTC_2247 cerulenin 830 nM 1.68375694609371 0.0684127641815479 no 273 0.0461143254627269 71 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2553 4-methylesculetin 85.09 µM 1.68254642081179 0.068553565425434 no 274 0.0462314656554195 60 5319502 SGTC_369 0957-0393 4.5 µM 1.67911668505603 0.0689537061850803 no 275 0.0465646525257552 81 6997992 SGTC_1959 st077091 55.8 µM 1.67890242227288 0.0689787634389157 no 276 0.0465855311975564 110 821356 YKL052C ASK1 SGTC_3122 9126309 49.47 µM 1.66627475095854 0.0704679547548053 no 277 0.0478293516607831 89 17591206 SGTC_2558 carylophyllene oxide 100 µM 1.66566080596057 0.0705409829481226 no 278 0.0478904963200162 70 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1441 4106-0040 13 µM 1.66375772300339 0.0707677225846993 no 279 0.0480804278665131 77 2904180 SGTC_3022 9087993 49.47 µM 1.66318845020464 0.0708356563351004 no 280 0.0481373594291152 62 17173644 SGTC_2686 alizarin 95.37 µM 1.65849976962651 0.071397083642893 no 281 0.0486083169939122 70 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1381 2324-0066 62.1 µM 1.65813796992097 0.07144054743631 no 282 0.0486448107616287 84 10885928 SGTC_1786 berberine 21.6 µM 1.65810834537228 0.071444107197647 no 283 0.0486477998804308 95 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3267 9137951 49.47 µM 1.65596414063275 0.0717021219796438 no 284 0.0488645404828032 65 16643986 SGTC_2232 chlorophetanol 41.5365 µM 1.65096167456491 0.0723068534322622 no 285 0.0493732004562626 78 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_683 panaxydol 45 µM 1.64865186470593 0.0725873941799384 no 286 0.0496094883969544 53 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1731 st035964 63 µM 1.63837662961598 0.0738454975032952 no 287 0.0506715756195689 102 6739575 SGTC_2345 9052315 157.45 µM 1.63684599137256 0.0740343269527953 no 288 0.0508313266125063 89 6469265 SGTC_1103 duloxetine 36.1 µM 1.63516671325579 0.0742419177074631 no 289 0.051007052014208 98 60835 A selective serotonin reuptake inhibitor. SGTC_1011 4112-3381 17.4 µM 1.63229024633121 0.0745985362826361 no 290 0.051309178491025 82 2877139 SGTC_2489 cantharidin 73.42 µM 1.6317550090345 0.0746650379603774 no 291 0.0513655533193076 90 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2007 4011539 71.82 µM 1.62817381203779 0.0751111558550363 no 292 0.0517440179953932 64 45595301 SGTC_603 3794-0023 45.9 µM 1.62428664035549 0.0755976871358994 no 293 0.0521573235768906 73 3802260 SGTC_1286 0929-0070 131 µM 1.62350306313763 0.0756960524105428 no 294 0.0522409545443689 84 1420408 SGTC_2430 5571206 200 µM 1.62181026389456 0.0759088884059048 no 295 0.0524219900421664 105 1731771 SGTC_1810 st050138 53 µM 1.62146723888609 0.0759520724848115 no 296 0.0524587352827848 97 3444541 SGTC_2789 5281112 71.43 µM 1.62100582668748 0.0760101900564157 no 297 0.0525081945436188 83 765948 SGTC_2400 5203494 178.7 µM 1.61656650466332 0.0765710798193219 no 298 0.0529859435096413 108 6777674 SGTC_320 4092-0846 5.34 µM 1.61408619091071 0.0768858249039397 no 299 0.0532543661135198 102 1359356 SGTC_1767 st044992 70.3 µM 1.61112109807687 0.0772633766481685 no 300 0.0535766653490222 70 9600693 SGTC_1051 3253-3903 78 µM 1.60772979331541 0.0776969237274925 no 301 0.0539471852317711 103 5509239 SGTC_3127 9126946 49.47 µM 1.60686319160156 0.0778080064738888 no 302 0.0540421912268765 84 27243249 SGTC_43 0570-0105 72.5 µM 1.60670955464281 0.0778277125403989 no 303 0.0540590483390061 86 1114046 YDL195W SEC31 SGTC_3286 9117135 37.221 µM 1.60667859035964 0.0778316845968993 no 304 0.0540624462571384 80 3438150 SGTC_3211 9128781 49.47 µM 1.60634853642253 0.0778740330317897 no 305 0.054098675791269 84 17194361 SGTC_3204 9114183 49.47 µM 1.60613361269193 0.077901618783293 no 306 0.0541222779811396 87 17027248 SGTC_2094 5332512 191.667 µM 1.60255154296348 0.0783624746800538 no 307 0.0545168496537979 79 755774 SGTC_256 clotrimazole 625 nM 1.60226332137358 0.0783996458787584 no 308 0.0545486964337512 89 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2989 9073649 71.4286 µM 1.60206046869951 0.0784258152820081 no 309 0.0545711192735348 99 21367202 SGTC_2805 7950783 58.44 µM 1.60150770421123 0.0784971593498627 no 310 0.0546322575048492 84 1178958 YDL195W SEC31 SGTC_1943 st076331 65.2 µM 1.59415222221786 0.0794512036985726 no 311 0.0554509723393531 74 24208415 SGTC_1506 4226-2149 212 µM 1.59328956024194 0.0795636679542279 no 312 0.0555476237986598 99 991114 SGTC_592 k241-0073 46.5 µM 1.5844489555418 0.0807231590165061 no 313 0.0565457944253086 91 4230158 SGTC_3310 9130229 44.1445 µM 1.58265766381541 0.0809596431313083 no 314 0.0567497563636135 82 7761258 SGTC_1839 st053978 48 µM 1.58219245907582 0.081021144341505 no 315 0.056802820672419 70 3788398 SGTC_1092 toremifene 6.32 µM 1.58145975754235 0.0811180807808451 no 316 0.0568864766610168 86 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_641 4092-0595 30 µM 1.57880071553611 0.0814706073449899 no 317 0.057190887220361 94 786260 SGTC_1814 st052110 31.539 µM 1.57872248841964 0.0814809958925523 no 318 0.0571998621376135 85 674163 SGTC_602 3130-1533 38.1 µM 1.57830084284361 0.0815370075568914 no 319 0.0572482561953669 108 720941 SGTC_347 4534-1311 26.2 µM 1.57791345717725 0.0815884937004875 no 320 0.0572927464931645 78 2862016 SGTC_2039 Aminomethylbenzodioxan 200 µM 1.57719148482092 0.0816845140602415 no 321 0.0573757358567718 90 15053 SGTC_646 4092-0839 27.3 µM 1.57288745337897 0.0822587070648238 no 322 0.0578724403917144 102 877796 SGTC_3083 9117465 49.47 µM 1.57162917045196 0.0824271452123992 no 323 0.0580182886535002 93 16420915 SGTC_1364 1653-0028 37.6 µM 1.56544193177878 0.0832591702153089 no 324 0.0587396614654642 72 5718652 SGTC_2990 9074105 71.4286 µM 1.56367901662175 0.0834973890924667 no 325 0.0589464839727275 77 6502001 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.55878317239428 0.0841616400415388 no 326 0.0595238541665715 96 23847180 SGTC_1545 lovastatin 49.4 µM 1.55804312241013 0.0842623915842146 no 327 0.0596115130940996 113 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1878 temozolomide 1 mM 1.5560429564055 0.0845351501804833 no 328 0.0598489390118045 85 5394 DNA alkylating agent. SGTC_2773 thioridazine 9.09 µM 1.55082437741846 0.0852499150173572 no 329 0.0604718884835202 79 5452 An antipsychotic. SGTC_692 k241-0027 77.8 µM 1.55005752995082 0.0853553270427562 no 330 0.0605638541979703 84 3600480 SGTC_1045 1348-1485 165 µM 1.54725935132866 0.0857407971690134 no 331 0.0609003596773937 92 6810614 SGTC_262 fenpropimorph 62.5 µM 1.54716213047838 0.0857542134582971 no 332 0.060912077560277 100 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1238 0333-0287 48.8 µM 1.54588854771703 0.085930110574775 no 333 0.0610657434238701 77 7226 SGTC_696 1560-0013 611 µM 1.5453743382595 0.0860012055561881 no 334 0.0611278718660808 99 1650269 SGTC_3251 9135047 49.47 µM 1.54292649385052 0.0863402498914382 no 335 0.0614243058794867 67 17682963 SGTC_217 ketoconazole 989 nM 1.54095224203222 0.0866144255780978 no 336 0.0616642048701941 95 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_3020 9089140 49.47 µM 1.54064669272761 0.0866569170532845 no 337 0.0617013986347685 98 17217859 SGTC_2342 7990637 118.86 µM 1.54010832238639 0.0867318238920865 no 338 0.0617669757472791 108 2033102 YER133W GLC7 SGTC_3113 9123498 49.47 µM 1.53774699036281 0.0870609424294472 no 339 0.0620552446615186 97 8897275 SGTC_35 0133-0054 64.071 µM 1.53528998746387 0.0874043847062751 no 340 0.0623563062413893 106 99677 SGTC_728 3030-5151 22.5 µM 1.53092643816614 0.0880168171086825 no 341 0.0628937871316401 74 3125388 SGTC_2835 9006588 71.43 µM 1.52895546164171 0.0882944941285116 no 342 0.0631377427764754 75 2345538 SGTC_1695 st026914 34.495 µM 1.51379382308106 0.0904523723056504 no 343 0.0650390698753353 84 3289191 SGTC_2067 5224629 34.075 µM 1.51329917744619 0.0905234264814937 no 344 0.0651018407754911 96 2835000 SGTC_2136 5328288 199.296 µM 1.51131755443314 0.0908084954849247 no 345 0.065353781760097 73 262395 SGTC_1913 st060213 96.1 µM 1.50785489741266 0.0913082186666532 no 346 0.065795834111557 93 688959 SGTC_1822 st052468 42 µM 1.50575155467669 0.091612762261969 no 347 0.0660654819639118 87 2873678 SGTC_3275 9138069 49.47 µM 1.50348730311273 0.0919414444280949 no 348 0.0663567143342012 96 17617007 SGTC_228 caffeine 993.056 µM 1.50298941452018 0.0920138356697032 no 349 0.0664208868515494 51 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_524 r073-0010 27.8 µM 1.5001811253365 0.0924229415339897 no 350 0.0667837455373531 109 2772106 SGTC_1633 st005664 67.9 µM 1.49795811687273 0.0927477380887118 no 351 0.0670720662887294 84 2063822 SGTC_2127 5253358 187.912 µM 1.49651421181197 0.0929591540957494 no 352 0.0672598536148881 87 20612 SGTC_705 1124-0212 310 µM 1.49621263581012 0.0930033556744154 no 353 0.06729912639995 113 9554485 SGTC_1853 st056710 91.2 µM 1.49130835230159 0.0937243518114538 no 354 0.0679402785431316 110 269167 SGTC_3212 9128307 49.47 µM 1.49091940950684 0.0937817077928136 no 355 0.0679913274150713 93 27243542 SGTC_132 0417-1715 25.805 µM 1.48610131991576 0.0944943637172864 no 356 0.0686261616184736 93 6769098 SGTC_2985 9022375 71.43 µM 1.48433821720027 0.0947561441410026 no 357 0.0688596081782795 94 4939335 SGTC_1116 jasmonic acid  1.58368 µM 1.4821190306081 0.0950864017992084 no 358 0.0691543129688736 90 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2071 5230951 39.92 µM 1.48127660856647 0.0952119921503307 no 359 0.0692664395490882 114 1799272 SGTC_3174 9107204 49.47 µM 1.4794782927331 0.09548049810519 no 360 0.0695062643803032 79 3938802 SGTC_444 curcumin 90.4 µM 1.47716667597314 0.0958264629550456 no 361 0.0698154820623908 103 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_13 0199-0087 65 µM 1.47615992736393 0.0959774244689289 no 362 0.0699504821573266 104 4589825 SGTC_1964 st076914 61 µM 1.46591859783099 0.0975230561815713 no 363 0.0713352323344055 125 24208661 SGTC_1610 st001799 48.1 µM 1.46559867656976 0.0975716313531027 no 364 0.0713788260144742 82 621897 SGTC_1724 st037281 8.293 µM 1.46270796357722 0.0980113467733345 no 365 0.0717736530773698 105 574124 YDL195W SEC31 SGTC_1225 1216-0074 20.6 µM 1.46168752860055 0.0981669145925917 no 366 0.0719134281707428 89 4241466 SGTC_1539 benzyladenosine 56 µM 1.45962624787104 0.0984817135122733 no 367 0.0721964107042967 99 92208 A nucleotide analog. SGTC_851 0394-0702 453 µM 1.45623141373601 0.0990017828022676 no 368 0.0726643291187286 135 762646 SGTC_3124 9127567 49.47 µM 1.45519637320392 0.0991607440613503 no 369 0.0728074523352585 82 17592030 SGTC_115 0527-0192 112.043 µM 1.45430078496975 0.0992984388310384 no 370 0.0729314664685405 155 4233931 SGTC_2978 9011784 42.97 µM 1.4500435213251 0.0999548959363879 no 371 0.0735231915981042 88 2994934 SGTC_419 nsc-638432 893 µM 1.43927520502058 0.101629472569178 no 372 0.0750362825217965 106 368090 SGTC_390 dec-rvkr-cmk 16.7 µM 1.43909180524978 0.10165816885213 no 373 0.075062256759718 105 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_255 tunicamycin 200.472 nM 1.43654492373405 0.102057285534609 no 374 0.0754236713993255 111 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_257 daunorubicin 18.5 µM 1.43629339622698 0.102096763677907 no 375 0.075459436186956 107 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2417 cerulenin 830 nM 1.43455736449895 0.102369543089481 no 376 0.0757066357011218 107 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2176 5809774 33.9695 µM 1.43443621751733 0.102388598451817 no 377 0.0757239092346855 81 2870539 SGTC_2160 5660466 132.927 µM 1.43422256895132 0.102422209790838 no 378 0.075754379262774 118 2859134 SGTC_1218 1348-1416 30.7 µM 1.43013993218438 0.103066035214956 no 379 0.0763384306405701 99 6787668 SGTC_176 1486-1328 72.834 µM 1.42859332737924 0.103310698482715 no 380 0.0765605765573307 121 22310231 SGTC_1085 doxorubicin 7.67 µM 1.42189801345086 0.104374719642127 no 381 0.077527929996708 123 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1730 st033808 45.1 µM 1.42096855811475 0.104523054411423 no 382 0.077662950138403 98 1045166 SGTC_3008 9078912 71.4286 µM 1.4188975457821 0.104854123089488 no 383 0.0779644439614944 100 16648731 SGTC_136 0097-0015 404.482 µM 1.41670348702285 0.105205689330203 no 384 0.0782848185625767 117 4861337 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.41610221988155 0.105302182442384 no 385 0.078372789129413 112 7104 SGTC_571 k831-0106 44.2 µM 1.41608101742639 0.105305586242855 no 386 0.078375892599024 117 4783639 SGTC_1149 3909-7961 23.3 µM 1.41171517122463 0.106008167288467 no 387 0.0790169222157852 101 735261 SGTC_1831 st055328 12 µM 1.40196753727337 0.107589030938117 no 388 0.0804624704194616 121 1103068 SGTC_1772 st048439 82.2 µM 1.39782831285117 0.108265440527169 no 389 0.0810823149957807 119 2927068 YDL195W SEC31 SGTC_1108 betulinic acid 729.144 nM 1.39517459671864 0.108700703398058 no 390 0.0814815977566769 101 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1940 st075990 51.1 µM 1.39441749848428 0.108825113170258 no 391 0.081595783505172 103 1084979 SGTC_622 1348-1566 26.3 µM 1.39307597751491 0.109045809263603 no 392 0.081798408276936 113 7340407 SGTC_1193 1488-0126 41.5 µM 1.39158455971911 0.109291542554388 no 393 0.0820241185620546 93 1384710 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.39015067075646 0.109528171976342 no 394 0.0822415646115694 120 688664 SGTC_1174 0739-0097 51.1 µM 1.38857542478223 0.109788552878614 no 395 0.0824809472901177 119 728447 SGTC_1496 4469-0713 57.4 µM 1.38612251798603 0.110194891168677 no 396 0.082854747763759 111 746691 SGTC_2982 9019404 25.97 µM 1.38455485417223 0.110455148153765 no 397 0.0830943120254267 97 22333232 SGTC_1514 1189-1591 158 µM 1.38240019992878 0.110813573486496 no 398 0.0834244273809148 114 767698 YMR146C TIF34 SGTC_1672 st016598 6.51 µM 1.38141905677463 0.110977061849161 no 399 0.0835750748956513 131 4665860 YNL267W PIK1 SGTC_2165 5727197 32.143 µM 1.37974819687265 0.111255875546565 no 400 0.0838320938105742 112 1361712 SGTC_2865 9030313 51.95 µM 1.37778373399894 0.111584323274824 no 401 0.0841350347775835 91 42562754 SGTC_1696 st025591 34.7925 µM 1.37452551015194 0.112130609498096 no 402 0.0846392980935233 97 2787147 SGTC_1458 k015-0034 6.33 µM 1.37172734677125 0.112601283917208 no 403 0.0850741659500671 90 3598957 SGTC_1800 st050079 29.0735 µM 1.3709582202876 0.112730904286606 no 404 0.0851939902386138 135 3645560 SGTC_1641 st009299 47.1 µM 1.3645495757166 0.113815092631218 no 405 0.0861973311945371 117 4046054 SGTC_166 k072-0058 166.424 µM 1.36447720981118 0.113827377483453 no 406 0.0862087110910663 130 5846229 SGTC_742 0kpi-0133 140 µM 1.36299125561007 0.114079842349929 no 407 0.0864426332537024 117 2728852 SGTC_527 4476-4215 268 µM 1.36285083952737 0.114103719771245 no 408 0.0864647623786263 88 4418754 SGTC_1444 4112-3581 28 µM 1.35630329226967 0.115221070332715 no 409 0.0875013442088041 114 2877249 SGTC_16 erodoxin 22.806 µM 1.35486651371989 0.115467296342405 no 410 0.0877300451216556 152 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1145 3546-0597 10.2 µM 1.35484511850712 0.115470965741642 no 411 0.0877334540961799 103 875334 SGTC_2360 9040895 200 µM 1.35468582653383 0.11549828781531 no 412 0.0877588377534704 103 4914414 SGTC_1741 st038134 10.228 µM 1.35384830761217 0.115642016281903 no 413 0.0878923890574067 106 1272587 SGTC_2965 9082772 38.63 µM 1.35324316024555 0.115745945991452 no 414 0.0879889805300237 71 16459634 SGTC_1062 mesoridazine 14.2 µM 1.35252149321605 0.115869973821881 no 415 0.0881042739139628 110 4078 A neuroleptic. SGTC_198 3454-2873 16.191 µM 1.35092998060845 0.11614382935735 no 416 0.088358931664448 139 710957 SGTC_490 phenamil 164 µM 1.3478947484611 0.116667382077344 no 417 0.0888461187008973 112 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1733 st037357 54.9 µM 1.34786927337607 0.116671783391335 no 418 0.0888502161697323 137 1272339 YGL099W LSG1 SGTC_286 k060-0067 22.9 µM 1.34639159945268 0.116927281662667 no 419 0.0890881293436322 128 5985051 SGTC_1091 telmisartan 47.6 µM 1.34342758025443 0.117440972419815 no 420 0.0895667806276425 127 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1331 1472-0049 76.2 µM 1.3405402164412 0.117942912676654 no 421 0.0900348893317913 131 24051409 SGTC_1264 0783-0040 158 µM 1.33996328421908 0.118043388414389 no 422 0.0901286409470673 103 2855798 SGTC_1440 4100-1550 40 µM 1.33910826247854 0.118192406210469 no 423 0.0902677155280542 118 742806 SGTC_1693 xanthone 101.9 µM 1.33428904517895 0.119034813355019 no 424 0.091054573205707 141 7020 An insecticide. SGTC_1409 3909-8004 61.9 µM 1.33241881827676 0.119362871230785 no 425 0.0913613008700571 115 2119279 SGTC_3180 9109287 49.47 µM 1.33224569729901 0.119393270739457 no 426 0.0913897323644626 122 18891271 SGTC_1459 k035-0031 35.7 µM 1.33184136364442 0.119464291758006 no 427 0.0914561612445733 102 3877128 YMR208W ERG12 SGTC_1030 k029-0042 36.7 µM 1.33157754313272 0.119510647774054 no 428 0.0914995241961797 115 6080581 SGTC_400 oxethazaine 37.5 µM 1.33012163318124 0.119766694584572 no 429 0.0917390994553648 123 4621 A local anesthetic. SGTC_2903 5923464 63.88 µM 1.32938575739275 0.119896258066167 no 430 0.0918603671407361 116 2876576 SGTC_92 0063-0024 660.874 µM 1.32564093507323 0.120557128736614 no 431 0.0924793301549966 109 3594437 SGTC_873 0591-4978 488 µM 1.3233475526667 0.120963119524194 no 432 0.0928599123495898 130 3305145 SGTC_1667 st014849 34.6 µM 1.32146347739004 0.12129737092152 no 433 0.0931734363189866 123 5348460 SGTC_1131 3454-3128 32.3 µM 1.31965871682799 0.12161815975247 no 434 0.0934744946303713 122 710982 SGTC_687 k029-0044 34.9 µM 1.31859512130669 0.121807488510588 no 435 0.0936522528012226 84 5829338 SGTC_723 4182-0001 115 µM 1.3175029187587 0.122002124956223 no 436 0.0938350516783637 116 744821 YLR208W SEC13 SGTC_3004 9076122 71.4286 µM 1.31725832522843 0.122045742774754 no 437 0.0938760246814984 119 44782551 SGTC_3035 9091303 49.47 µM 1.31674306205854 0.122137664337675 no 438 0.0939623820247061 116 25237002 SGTC_752 1896-0090 130 µM 1.31233496852991 0.12292604344579 no 439 0.0947035692161253 130 772567 SGTC_3023 9089636 49.47 µM 1.3115660164036 0.123063933738974 no 440 0.0948333028204301 117 17249241 SGTC_1842 st055362 61.2 µM 1.31040840478934 0.123271723774802 no 441 0.0950288559259585 110 676032 SGTC_575 k072-0246 11.9 µM 1.30929926824282 0.123471043087051 no 442 0.0952164987103831 126 6796779 SGTC_2758 dehydroepiandrosterone 69.35 µM 1.30701400613687 0.123882431548179 no 443 0.0956039773531395 153 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2563 tomatine 8.54 µM 1.30635180595615 0.124001818620185 no 444 0.0957164735335617 122 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_814 3342-0569 96 µM 1.3016067560237 0.1248596521284 no 445 0.0965254245568188 131 4346283 SGTC_1079 idarubicin 2.36 µM 1.30038709819816 0.12508081615473 no 446 0.0967341648024375 134 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2853 9015042 58.44 µM 1.29884786694943 0.125360319673813 no 447 0.0969980718941691 104 6457456 SGTC_517 1365-0151 113 µM 1.2988164918044 0.125366021505176 no 448 0.0970034567738746 111 768657 SGTC_1319 1306-0155 43.7 µM 1.29831282019073 0.125457578949581 no 449 0.0970899313874932 131 3122360 SGTC_1017 4239-0030 168 µM 1.2944969846783 0.126152737840876 no 450 0.0977469050769212 128 1149593 SGTC_1081 sertraline 6 µM 1.29446157946526 0.126159200416738 no 451 0.0977530160268433 135 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_661 1304-0007 33.6 µM 1.29372973770075 0.126292836470203 no 452 0.0978793948610726 132 3117130 SGTC_3003 9075612 71.4286 µM 1.29321031603013 0.12638774394156 no 453 0.0979691643490394 142 6501993 SGTC_1414 3917-0015 5.4 µM 1.29202513716603 0.126604482981877 no 454 0.0981742197507452 113 6618702 SGTC_2696 st077691 74.316 µM 1.29083400199942 0.126822571970576 no 455 0.0983806223016582 132 757133 SGTC_1424 4048-1941 275 µM 1.28889706539552 0.127177770496361 no 456 0.0987169372129104 123 X1424 SGTC_519 k048-0011 62.8 µM 1.28885474697761 0.127185538634144 no 457 0.0987242944415553 123 6836379 SGTC_2014 4013930 200 µM 1.28868159302019 0.127217326904875 no 458 0.098754402139829 122 64556 SGTC_2120 5538279 151.968 µM 1.28209069247118 0.128431421003161 no 459 0.0999054168066909 108 2058197 SGTC_1516 st013856 110 µM 1.28183435878418 0.128478801565568 no 460 0.0999503792510058 122 5281404 A mutagen and neurotoxin. SGTC_574 1315-0397 40 µM 1.27688178670388 0.129396614297274 no 461 0.100821992593677 149 6794277 SGTC_2333 9017922 200 µM 1.274549144248 0.12983047076383 no 462 0.101234433789409 110 3163164 SGTC_3191 9110352 49.47 µM 1.26705332759544 0.131231458645015 no 463 0.102568111205319 120 17122424 SGTC_193 1273-0060 1.558 µM 1.26682268478466 0.131274731338433 no 464 0.102609349435888 129 2847393 YHR072W ERG7 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.26470763350628 0.13167201208918 no 465 0.102988076272035 135 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2855 9016525 58.44 µM 1.26464892826901 0.13168305081127 no 466 0.102998602655679 142 43811474 SGTC_3106 9121286 49.47 µM 1.2633669195205 0.131924274392639 no 467 0.103228673424809 108 15943471 SGTC_875 0709-0210 25.7 µM 1.26324907509843 0.131946463360516 no 468 0.103249840633336 141 6251364 SGTC_2869 9037858 32.47 µM 1.26081511943098 0.132405329416799 no 469 0.103687732572348 123 27187042 SGTC_779 1360-0071 233 µM 1.25931079543904 0.13268948418848 no 470 0.103959047731846 145 7566 SGTC_2504 purpurogallin 52.29 µM 1.25604713683588 0.133307406565017 no 471 0.104549440279131 119 5281571 An antioxidant. SGTC_1291 0993-0025 5.79 µM 1.25549449998552 0.133412235340397 no 472 0.104649651723325 128 4353356 SGTC_733 4069-0007 56.1 µM 1.25427794493538 0.133643201434665 no 473 0.104870498733614 143 5717425 YNL287W SEC21 SGTC_3326 9140064 16.379 µM 1.25080870246052 0.134303355307105 no 474 0.105502139550804 122 1868434 SGTC_1111 tnp00062 510.699 nM 1.2496579478048 0.134522823444904 no 475 0.105712262544329 127 676306 SGTC_305 1682-2595 20.8 µM 1.24607468587177 0.135207787620408 no 476 0.106368488655718 137 226033 SGTC_1308 1187-1617 41.4 µM 1.24468793128103 0.135473515581775 no 477 0.106623241969101 142 2882570 SGTC_3054 9094397 49.47 µM 1.24459939510444 0.135490492904249 no 478 0.106639521422522 145 2598354 SGTC_500 h-89 112 µM 1.24220192805258 0.135950775343792 no 479 0.107081034243371 147 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_144 4161-2749 112.381 µM 1.23981936692393 0.136409255506303 no 480 0.107521106605823 156 797501 YMR168C CEP3 SGTC_2182 6325192 200 µM 1.23889529237826 0.136587361035939 no 481 0.107692138650738 133 736248 SGTC_2233 sulbentine 40.3845 µM 1.23709520526181 0.136934765113236 no 482 0.108025869811643 163 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1003 4049-0218 100 µM 1.23669345632923 0.137012382168008 no 483 0.108100454484266 156 295161 SGTC_583 1488-1091 88.9 µM 1.22849532666352 0.138602810949256 no 484 0.109630541325437 162 4303273 SGTC_1865 st057639 52.2 µM 1.22738778999354 0.138818632428704 no 485 0.109838436684018 150 688818 SGTC_706 4262-0057 46.9 µM 1.22649974090157 0.138991848435009 no 486 0.110005336379621 130 883298 SGTC_3343 9148379 18.9835 µM 1.22555106405798 0.13917705251546 no 487 0.110183831374232 123 1955036 SGTC_364 0083-0097 67.7 µM 1.21127854685828 0.141983658416451 no 488 0.112894333961247 134 5207356 SGTC_1579 chlormadinone acetate 49.4 µM 1.21114123624276 0.142010844512989 no 489 0.112920639838727 144 45114258 A steroidal progestin. SGTC_2614 arthonioic acid 13.39 µM 1.20912869580972 0.142409711254558 no 490 0.113306703131607 121 6710684 SGTC_2414 st077232 92.9 µM 1.20516874486381 0.143196747332432 no 491 0.114069082786058 116 729801 SGTC_98 0074-0023 107.663 µM 1.20506517643888 0.143217370795869 no 492 0.114089070954634 119 3563821 SGTC_77 0828-0286 12.516 µM 1.20392191790264 0.143445159876573 no 493 0.114309879710301 128 745345 SGTC_614 0462-0418 107 µM 1.20160692042749 0.143907161392912 no 494 0.114757929479586 129 5188303 SGTC_1999 st074831 12.5 µM 1.20135700700036 0.143957096301952 no 495 0.114806372902532 158 17112523 SGTC_2639 lactacystin 53 µM 1.1969381362113 0.144841955970461 no 496 0.115665334176876 123 3870 A proteasome inhibitor. SGTC_1534 6-azauridine 81.6 µM 1.19189283342873 0.145856724996983 no 497 0.116651634298677 158 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_3110 9122132 49.47 µM 1.18883626537665 0.146473815634459 no 498 0.117252052108632 120 918317 SGTC_1383 3049-0032 20.7 µM 1.18843473440619 0.146555010782428 no 499 0.117331089334979 161 712864 SGTC_982 1491-0518 27.5 µM 1.18823481446892 0.14659544863755 no 500 0.11737045557797 124 3091256 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.18451604108486 0.147349011002271 no 501 0.118104425119502 122 521171 SGTC_2733 amorolfine 100 µM 1.18334074036023 0.14758770973831 no 502 0.118337066377641 164 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1665 st014639 11.4 µM 1.18212753708535 0.147834377867194 no 503 0.11857754974895 148 981133 YIL048W NEO1 SGTC_1227 3909-8010 46.6 µM 1.18158272822464 0.147945238001221 no 504 0.118685655044751 121 15982272 SGTC_2363 9053361 176 µM 1.18146521465168 0.147969157480941 no 505 0.11870898214676 151 6469797 YMR079W SEC14 SGTC_1484 3473-2379 286 µM 1.18115059401934 0.148033210160466 no 506 0.11877145204779 127 671917 SGTC_162 k030-0015 37.8 µM 1.17478899262344 0.149332330879574 no 507 0.120039572494321 159 1809920 YMR134W ERG29 SGTC_2184 6075246 200 µM 1.17217794144277 0.149867737660483 no 508 0.120562811327933 142 2267320 SGTC_3170 9103054 49.47 µM 1.17212509779339 0.149878586669237 no 509 0.12057341742909 141 16432970 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.17064852737667 0.150181944171986 no 510 0.120870041433972 129 688664 SGTC_350 k064-0020 19.8 µM 1.17022396844519 0.15026924438831 no 511 0.12095542484111 151 2790705 SGTC_1771 st048882 4.1505 µM 1.16981066142443 0.150354263403711 no 512 0.121038586126464 155 4580403 SGTC_2734 clemastine 41.6 µM 1.1694711450018 0.150424127352803 no 513 0.121106930132635 155 26987 Clemastine is a selective histamine H1 antagonist. SGTC_61 0978-8327 98.565 µM 1.168833975439 0.150555299212286 no 514 0.121235264413411 139 6150059 YHR072W ERG7 SGTC_1301 naphtanilide LB 4.81 µM 1.16773975341612 0.150780740569537 no 515 0.12145587813245 164 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_561 1550-0330 72.9 µM 1.16768847648448 0.15079131060924 no 516 0.121466223349739 152 6812934 SGTC_2435 5706476 10.6 µM 1.16719666499641 0.150892715892287 no 517 0.121565478705575 138 5725375 SGTC_3193 9111931 49.47 µM 1.16523663359927 0.151297300316791 no 518 0.12196161037674 148 17087244 SGTC_2329 6138490 200 µM 1.16339161693525 0.1516788023712 no 519 0.122335324606765 144 720019 SGTC_2533 agelasine 13.65 µM 1.16325999465256 0.15170604288959 no 520 0.122362015817567 145 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_346 4513-0042 7.16 µM 1.16103436557813 0.152167150879826 no 521 0.122813962127638 158 2827372 SGTC_1735 st034310 56.75 µM 1.1573621436683 0.152929997863822 no 522 0.123562216915943 160 871153 SGTC_2540 epiandrosterone 100 µM 1.15654246681462 0.153100618539345 no 523 0.123729669853117 152 441302 A steroid. SGTC_943 3253-1379 105 µM 1.15581346988959 0.153252469607351 no 524 0.123878731095012 166 668464 SGTC_2874 9043904 71.43 µM 1.15401485342538 0.153627550631141 no 525 0.124247039693182 152 4463428 SGTC_866 0495-0101 262 µM 1.15254174240849 0.15393520360524 no 526 0.124549263511131 144 635694 SGTC_3082 9117008 49.47 µM 1.14966009564177 0.154538201317209 no 527 0.125141947953725 146 41448529 SGTC_2438 5259590 200 µM 1.14413785895978 0.155698111539986 no 528 0.126283234539087 155 1201127 SGTC_1929 genistein trimethyl ether 50.5 µM 1.14345724663926 0.155841466161302 no 529 0.126424397915306 149 136420 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.14143638865978 0.156267623925723 no 530 0.126844184560965 154 4213774 SGTC_89 0302-0250 142.109 µM 1.14116954906571 0.156323952279366 no 531 0.126899686776577 167 4203518 YLR208W SEC13 SGTC_2132 5317594 122.667 µM 1.14092403964149 0.156375789764395 no 532 0.126950767281113 160 794577 SGTC_3166 9102297 49.47 µM 1.14082619347865 0.156396452407118 no 533 0.126971129067533 152 25237072 SGTC_804 1595-0054 20.9 µM 1.14081274754291 0.156399291990268 no 534 0.126973927344389 162 761523 Stimulates phospholipase C. SGTC_44 0929-0055 61.211 µM 1.1405850179117 0.156447390284213 no 535 0.127021327409115 164 1379590 SGTC_282 k297-0036 65.7 µM 1.13992035672825 0.156587827664807 no 536 0.127159741629878 154 5061378 SGTC_958 1222-0007 33 µM 1.13531669848175 0.15756281990008 no 537 0.12812132407412 170 7312461 SGTC_2070 5230947 200 µM 1.13471380179967 0.157690799998008 no 538 0.12824762628123 171 2835538 SGTC_3236 9132701 49.47 µM 1.13270640692747 0.158117412499687 no 539 0.128668783115073 158 24282524 SGTC_577 r071-0003 38.6 µM 1.13146647002457 0.158381302599699 no 540 0.128929404156924 170 4568517 YMR134W ERG29 SGTC_784 4579-0127 173 µM 1.13039297487354 0.158610002885143 no 541 0.129155336494223 160 1948547 SGTC_2464 5717415 7.67 µM 1.12793721468197 0.159133998542949 no 542 0.129673217901673 155 5285744 SGTC_2084 5306078 60.6385 µM 1.12608364663542 0.159530252103819 no 543 0.130065057663137 164 679340 SGTC_3205 9113483 49.47 µM 1.12419184568583 0.159935344441574 no 544 0.130465824005563 145 17018033 SGTC_612 0302-0167 22.4 µM 1.12385784251775 0.160006934530362 no 545 0.130536669120979 172 235821 SGTC_387 norethindrone acetate 66.7 µM 1.11860412822921 0.161135770007831 no 546 0.131654530761965 151 541197 SGTC_2912 7964298 10.93 µM 1.11303417104721 0.162338215773923 no 547 0.132846876962157 190 2975850 SGTC_2756 carbadox 75.1 µM 1.10909833439236 0.163191399328844 no 548 0.133693881681257 178 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2697 mebhydrolin 72.4 µM 1.109006789508 0.16321127841105 no 549 0.133713626518776 140 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_93 0109-0045 59.227 µM 1.1088567932491 0.163243853681042 no 550 0.133745982760995 161 88733 SGTC_295 k015-0027 31 µM 1.10605930882385 0.16385216827927 no 551 0.1343504247777 124 3887424 SGTC_106 0092-0003 11.579 µM 1.10245987535074 0.164637028465039 no 552 0.135130896653197 150 1072148 SGTC_3213 9129884 49.47 µM 1.10184310983492 0.1647717588913 no 553 0.135264942438957 149 17190742 SGTC_2258 7960471 200 µM 1.09946351298822 0.165292243258758 no 554 0.135782970297041 144 2974708 SGTC_2850 9015429 58.44 µM 1.0970188003013 0.16582807704515 no 555 0.136316586886384 171 6457570 SGTC_2482 5981709 142.65 µM 1.08840968726675 0.167723956411782 no 556 0.138207143242542 180 877755 SGTC_2929 9013348 24.6 µM 1.08612878433492 0.168228581444331 no 557 0.13871100955358 143 2995952 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.08584105631738 0.16829230745062 no 558 0.13877465930975 168 16623 A steroid. SGTC_2971 9092186 9.93 µM 1.08559204713083 0.168347470541531 no 559 0.138829759933778 144 25236400 SGTC_674 0498-0004 451 µM 1.08252141921767 0.169028663504439 no 560 0.139510451565601 191 4231473 SGTC_399 oxolinic acid 75 µM 1.08096601942642 0.169374390392712 no 561 0.139856114678588 162 4628 A DNA gyrase inhibitor. SGTC_2887 9044784 58.44 µM 1.08063172060845 0.16944875596262 no 562 0.139930483264955 192 6465546 SGTC_2437 5741531 144.16 µM 1.08025178597979 0.169533298761979 no 563 0.14001503668164 186 2262990 SGTC_2667 digitoxin 100 µM 1.07705566528029 0.170245568563713 no 564 0.140727698983615 126 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1406 3909-7906 11.9 µM 1.0764458371552 0.170381688985235 no 565 0.140863955946295 162 X1406 SGTC_2191 5911152 200 µM 1.07620900591858 0.170434571139702 no 566 0.140916896460709 148 2875902 SGTC_2862 9027634 71.43 µM 1.0761628801035 0.170444871816792 no 567 0.14092720885136 158 5012562 SGTC_480 am 92016 50 µM 1.07376652947262 0.170980565929028 no 568 0.141463667366654 198 2129 K+ channel blocker. SGTC_1995 st072814 61.1 µM 1.07257129773404 0.17124815709955 no 569 0.14173175424109 157 5769371 SGTC_2717 st081029 62.2815 µM 1.07237939888186 0.171291144779504 no 570 0.141774828613056 163 5292846 SGTC_2565 isoliquiritigenin 100 µM 1.07107439698692 0.171583664057415 no 571 0.14206798962218 164 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_46 0329-0187a 2.197 µM 1.07078795794421 0.171647912742444 no 572 0.142132391347407 161 46494817 SGTC_1464 k208-0027 110 µM 1.06894423242872 0.172061830782535 no 573 0.142547399554734 180 X1464 SGTC_2320 7373003 200 µM 1.06885247994889 0.172082445925596 no 574 0.142568073704858 170 5415828 SGTC_2072 5231554 129 µM 1.06804581388088 0.172263757235403 no 575 0.142749923213459 184 789545 SGTC_3284 9108171 64.8615 µM 1.06707885138911 0.172481258339253 no 576 0.142968115454028 168 8687505 SGTC_3092 9117248 49.47 µM 1.06651120150274 0.172609022688884 no 577 0.143096308908477 185 17141857 SGTC_2087 5276107 200 µM 1.06636076127041 0.172642893283082 no 578 0.143130296125828 166 144405 SGTC_1053 3366-3204 134 µM 1.06519697239517 0.172905055593349 no 579 0.143393401709687 169 3632071 YPR165W RHO1 SGTC_906 1165-0455 526 µM 1.06519237853498 0.17290609093722 no 580 0.143394440921226 174 3252859 SGTC_2967 9089538 49.85 µM 1.06452844828976 0.173055766138647 no 581 0.143544687035417 193 728216 SGTC_796 1234-0020 70.7 µM 1.06330928498906 0.173330826909525 no 582 0.143820857936503 157 46495034 SGTC_1147 3809-1045 12.3 µM 1.06275064618642 0.173456956795456 no 583 0.143947523243505 163 325925 SGTC_901 1112-0062 60.1 µM 1.06156015260638 0.173725942169681 no 584 0.144217705755609 160 1908457 SGTC_1828 st055811 49 µM 1.060333148771 0.17400345435849 no 585 0.144496531815847 152 5877589 SGTC_1774 st048371 48.465 µM 1.05955933626032 0.174178612833779 no 586 0.144672560693887 208 4242727 SGTC_2695 st077686 51.995 µM 1.0591699994882 0.174266784598484 no 587 0.144761182631072 143 2876092 SGTC_208 k072-0098 12.366 µM 1.05762748017878 0.174616392377683 no 588 0.14511265454565 179 5948901 SGTC_1181 1222-0449 220 µM 1.05388152417716 0.175467255537799 no 589 0.145968581369969 170 658318 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.05214706960191 0.175862111278813 no 590 0.146366039741468 152 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1304 1165-0502 251 µM 1.05190866959231 0.175916427982916 no 591 0.146420726965799 174 767425 SGTC_3338 9144300 39.5675 µM 1.0518260686701 0.175935250132299 no 592 0.146439678214635 147 4901274 SGTC_1618 st003135 44.5 µM 1.05175892766704 0.175950550392442 no 593 0.146455083685054 181 1270615 SGTC_2768 sulfasalazine 50.2 µM 1.04931697523708 0.176507601168788 no 594 0.147016127875547 156 5384001 An antioxidant and salicylic acid derivative. SGTC_3050 9093513 49.47 µM 1.04602073305919 0.177261296910596 no 595 0.147775730065253 196 25236664 SGTC_974 1326-0144 138 µM 1.04591327659772 0.177285901314789 no 596 0.147800537012259 167 5411856 SGTC_2212 7123476 200 µM 1.04568122586862 0.177339041539079 no 597 0.147854116780003 152 1085715 SGTC_3074 9116018 49.47 µM 1.04456276988387 0.177595311926598 no 598 0.148112547048838 193 17027303 SGTC_94 0334-0113 514.748 µM 1.0438365740826 0.177761829310476 no 599 0.148280503490251 186 6795178 SGTC_2286 7945697 125 µM 1.04160799855263 0.178273458473136 no 600 0.148796729403588 166 1245733 SGTC_2801 7907800 81.82 µM 1.04138030273912 0.178325784341388 no 601 0.148849540272544 175 6620925 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.0399005109209 0.178666085190603 no 602 0.149193062541696 152 16486 A toxic proline analog. SGTC_1026 k007-1105 30.6 µM 1.03291055445451 0.180279055234778 no 603 0.150822879530765 192 7066794 SGTC_3229 9132204 49.47 µM 1.03281077029541 0.180302146925021 no 604 0.150846231243621 152 17682924 SGTC_2192 5915882 198.485 µM 1.03251598428574 0.180370376080709 no 605 0.150915231784529 171 2876149 SGTC_3031 9088762 49.47 µM 1.03217334343053 0.180449701746841 no 606 0.150995460102451 175 205253 SGTC_342 k048-0088 23.3 µM 1.02923715098634 0.18113036427168 no 607 0.151684124296013 189 6820570 SGTC_1662 st014054 52 µM 1.02850552674114 0.181300217993941 no 608 0.151856046213917 165 2838777 SGTC_187 1488-2104 32.728 µM 1.02790917899808 0.18143873971149 no 609 0.151996275697043 170 2852859 SGTC_2992 9074591 71.4286 µM 1.02758082309534 0.181515039633583 no 610 0.15207352436427 175 17741321 SGTC_298 1391-0729 10 µM 1.02729588183312 0.181581267587421 no 611 0.152140580475133 174 3237558 SGTC_2818 7996756 12.99 µM 1.0269643788896 0.181658336747358 no 612 0.152218618796349 191 2241621 SGTC_1422 4031-0024 15.5 µM 1.0262969093566 0.181813574878275 no 613 0.152375826828511 190 782427 SGTC_1194 1488-0194 225 µM 1.02485275950691 0.182149734967872 no 614 0.152716333830383 176 1391452 SGTC_1816 st051957 91.6 µM 1.02406731781497 0.182332728135461 no 615 0.152901739921608 169 674121 SGTC_2607 solasodine 47.35 µM 1.02372927984365 0.182411519981507 no 616 0.152981580815996 199 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1159 4092-0538 61.2 µM 1.02358071520664 0.182446155014206 no 617 0.153016678909732 183 717301 SGTC_2401 5128683 200 µM 1.02197131669291 0.182821619074152 no 618 0.153397238157922 164 708373 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.02129688240128 0.182979104289179 no 619 0.153556901518758 173 3256 An antibiotic and ribosome inhibitor. SGTC_923 1900-2434 73.3 µM 1.02067324433638 0.18312480352614 no 620 0.153704637444361 200 5910570 SGTC_813 k007-0158 173 µM 1.01847418912474 0.183639141410478 no 621 0.154226330443537 180 6523916 SGTC_2664 lyso-paf C-16 73.48 µM 1.0168310015224 0.184024054210943 no 622 0.154616915735495 196 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_461 N-acetylfarnesylcysteine 136 µM 1.01654173769864 0.18409186553551 no 623 0.1546857412851 188 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_302 1094-0063 18.9 µM 1.01583810864027 0.18425688029409 no 624 0.15485324270011 208 5440289 SGTC_2625 euphol 100 µM 1.01429531299105 0.184619018060407 no 625 0.15522092993161 195 6708538 A triterpene alcohol. SGTC_2187 6125751 200 µM 1.01421053390594 0.18463893092912 no 626 0.155241151622706 190 874498 SGTC_3232 9132874 49.47 µM 1.01413823277645 0.184655914036983 no 627 0.155258398418553 179 3784940 SGTC_1360 1598-0022 39.8 µM 1.01307779383494 0.184905116457208 no 628 0.155511502062047 192 761525 SGTC_2326 6164455 177.58 µM 1.01173303062969 0.185221435289029 no 629 0.155832858957796 193 2888790 SGTC_2445 5742597 35.57 µM 1.0112109237224 0.185344337196584 no 630 0.155957744300364 199 1774255 SGTC_2057 5236571 38.335 µM 1.01068098722851 0.18546913392087 no 631 0.156084569883466 159 54684039 YBR257W POP4 SGTC_2834 9001755 58.44 µM 1.00704515112991 0.186326756355559 no 632 0.156956538564757 175 2989575 SGTC_1700 st030840 7.9285 µM 1.00620445923715 0.186525408275717 no 633 0.157158613774312 202 5499307 SGTC_1137 ixabepilone 100 µM 1.0049017265902 0.18683349744798 no 634 0.157472086491453 171 154225 A novel microtubule stabilizer. SGTC_1202 1988-0068 29.6 µM 1.004894905319 0.186835111469846 no 635 0.157473728954548 161 2850480 SGTC_410 α-linolenic acid 100 µM 1.00486928731024 0.186841173177512 no 636 0.15747989749975 193 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3000 9075062 71.4286 µM 1.00364553186858 0.187130878730406 no 637 0.157774749824081 172 17057871 SGTC_2814 7977482 42.97 µM 1.00255752142375 0.187388681885756 no 638 0.158037199973789 193 6456762 SGTC_2676 harmalol 100 µM 1.00253379224315 0.187394306940255 no 639 0.158042927124274 184 5459187 A monoamine oxidase inhibitor SGTC_1557 sumaresinolic acid 42.3 µM 1.00064625807961 0.187842085382897 no 640 0.158498928925179 157 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1163 k060-0048 49.9 µM 1.00017158594321 0.187954795420991 no 641 0.15861373871848 173 6809982 SGTC_2856 9022925 19.48 µM 0.999524215208214 0.188108579715758 no 642 0.158770407309838 168 4944862 SGTC_3120 9124077 49.47 µM 0.998868834781495 0.188264345810778 no 643 0.158929117603872 191 18774327 YGL155W CDC43 SGTC_1298 1079-1278 263 µM 0.998175626575617 0.188429189115644 no 644 0.159097101570751 185 2840950 SGTC_2155 5570423 76 µM 0.994961458415357 0.189194673544479 no 645 0.159877504919655 190 797402 SGTC_2728 chlorpromazine 9.18 µM 0.994755272811001 0.189243843857761 no 646 0.159927652318126 214 2726 A thorazine and dopamine antagonist. SGTC_3016 9080866 49.47 µM 0.992650174811035 0.189746309274556 no 647 0.160440232019429 182 17066299 SGTC_2099 5377090 177.372 µM 0.991695454935487 0.18997446135537 no 648 0.160673054433672 195 2243829 SGTC_1109 tnp00067 928.257 nM 0.987485128562082 0.190982625035635 no 649 0.161702434914954 169 676295 SGTC_2765 myclobutanil 7.74 µM 0.98662737210063 0.191188416685814 no 650 0.161912673217228 204 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_812 4251-0442 148 µM 0.984945761714325 0.191592260475151 no 651 0.162325356761354 195 5723007 SGTC_1707 st032323 6.317 µM 0.978024873959202 0.193259826210516 no 652 0.164031010955497 197 3132057 YMR211W DML1 SGTC_227 fluconazole 33.516 µM 0.974968896622804 0.193998964803369 no 653 0.164787844317224 227 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_727 3032-0951 202 µM 0.974043916253389 0.194223025723686 no 654 0.165017367172531 177 3652836 SGTC_757 1066-0008 322 µM 0.973412090414474 0.194376165451097 no 655 0.165174266149356 192 6842497 SGTC_2852 9023854 51.95 µM 0.973196495095092 0.194428437504633 no 656 0.165227826227114 210 19798528 SGTC_3052 9092717 49.47 µM 0.972669113766726 0.194556339539828 no 657 0.165358890287641 199 25237534 SGTC_2557 derrustone 83.84 µM 0.972438462149883 0.194612293923391 no 658 0.165416232638108 189 629853 An antioxidant. SGTC_1604 st002052 72.4 µM 0.972391088735472 0.194623787576876 no 659 0.165428011745627 169 6254834 YHR062C RPP1 SGTC_702 1488-0190 94 µM 0.971865256062541 0.19475139189893 no 660 0.165558793236799 153 949357 SGTC_2979 9012552 45.46 µM 0.971076387484124 0.194942922819642 no 661 0.165755120588195 207 17100905 SGTC_1762 st045503 25.4615 µM 0.969451356241467 0.195337828096708 no 662 0.166160019643815 182 4645554 SGTC_888 0916-0002 6.97 µM 0.968664259446764 0.195529278190099 no 663 0.166356365206273 168 2802138 YIL048W NEO1 SGTC_801 0866-0028 10.1 µM 0.968439628558532 0.19558393735004 no 664 0.166412428067939 189 6849771 SGTC_557 1315-0110 16.2 µM 0.966103715907397 0.196152881831782 no 665 0.166996142664562 179 6833801 SGTC_1864 st057645 30.4 µM 0.965293337322437 0.196350495227547 no 666 0.167198954001073 209 688666 SGTC_613 3914-0030 117 µM 0.964741594688451 0.196485108449951 no 667 0.16733712800734 162 1145395 SGTC_119 0121-0043 24.815 µM 0.962826451056372 0.196952795700773 no 668 0.167817312090542 211 1092378 SGTC_953 1188-0045 9.7 µM 0.961520052429412 0.1972722107955 no 669 0.168145373977054 197 6144426 SGTC_506 n9-isopropylolomoucine 153 µM 0.959922687679212 0.197663192789805 no 670 0.168547063396841 171 6610355 SGTC_1611 st001856 99.4 µM 0.959655438285261 0.197728652295249 no 671 0.168614328812815 211 647478 SGTC_1485 3909-9022 254 µM 0.958802796880901 0.197937584044443 no 672 0.168829049977932 204 714516 SGTC_2830 7992007 71.43 µM 0.95791822855993 0.198154480058557 no 673 0.169051996912388 197 1952075 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.955896780130422 0.198650677231146 no 674 0.16956219295251 180 2374 Ca(2+)-ATPase inhibitor. SGTC_2828 7998861 71.43 µM 0.955228519694282 0.198814877211333 no 675 0.169731073128939 151 2988188 SGTC_743 1275-0778 158 µM 0.953886030154644 0.199144990940825 no 676 0.170070667778509 221 2849257 YMR203W TOM40 SGTC_321 4534-3890 65.3 µM 0.952765189472265 0.199420854704724 no 677 0.170354527703564 206 699746 SGTC_726 3448-4391 34.2 µM 0.952103152010374 0.199583904834011 no 678 0.170522335320106 203 1356692 SGTC_776 4476-4378 112 µM 0.951757238968184 0.199669130050706 no 679 0.170610056496838 201 2892008 SGTC_3220 9131269 49.47 µM 0.951693268325573 0.199684893381359 no 680 0.170626282178203 200 17722206 SGTC_167 3672-0051 66.205 µM 0.951116439773373 0.199827066444765 no 681 0.170772635096448 183 3237971 SGTC_3184 9108758 49.47 µM 0.950676120810729 0.199935634450879 no 682 0.170884406861207 195 902885 SGTC_3244 9134489 49.47 µM 0.950203696464812 0.200052158011211 no 683 0.171004380384064 200 16584271 SGTC_669 0108-0021 26.2 µM 0.948148114231248 0.200559642880217 no 684 0.171527028496185 226 17201 SGTC_1419 3993-2473 62.6 µM 0.948027087065618 0.200589546305066 no 685 0.171557832400556 205 704026 SGTC_1432 4049-0298 68.4 µM 0.945215455082068 0.20128499835956 no 686 0.172274445359008 196 741646 SGTC_458 nppb 133 µM 0.944012388489396 0.201583015735694 no 687 0.172581658814158 175 4549 A chloride channel blocker. SGTC_1340 1486-1359 257 µM 0.939255705100707 0.202763902753312 no 688 0.173799737389792 204 4309068 SGTC_235 0330-0087 5 mM 0.938795419607112 0.202878391452026 no 689 0.173917895529894 182 46494818 YHR062C RPP1 SGTC_3228 9131799 49.47 µM 0.937364443851895 0.203234570472778 no 690 0.174285562043494 208 17015818 SGTC_2036 5160441 105 µM 0.93485646112084 0.203859722960753 no 691 0.174931138766146 221 134534 YIL048W NEO1 SGTC_3102 9121669 49.47 µM 0.934576757964914 0.203929514153634 no 692 0.175003230744416 219 41905072 SGTC_2993 9054257 71.4286 µM 0.933389863227666 0.20422582505077 no 693 0.175309356124872 215 6470217 YGL055W OLE1 SGTC_964 1287-0107 19.4 µM 0.929861471550349 0.205108208565122 no 694 0.176221406876123 187 51516812 YPR165W RHO1 SGTC_2832 7992762 51.95 µM 0.926730974586053 0.205892979855156 no 695 0.17703311556392 198 2985177 SGTC_1600 coumarin 106 71.1 µM 0.925362991567911 0.206236472350042 no 696 0.177388561312887 211 100336 A hepatotoxic, DNA x-linker. SGTC_2502 avocadyne acetate 18.59 µM 0.919917366690818 0.207607200326986 no 697 0.178807971386785 193 3952079 SGTC_634 1611-4317 11.2 µM 0.919583667103815 0.207691371125322 no 698 0.178895182529618 214 2843522 SGTC_950 1165-0508 94.1 µM 0.918513640531729 0.207961405476912 no 699 0.179175010495343 202 6148369 SGTC_1148 3909-7663 27.7 µM 0.918430475717831 0.20798240181726 no 700 0.179196770863796 193 4084526 SGTC_582 0987-0078 156 µM 0.91701708001594 0.208339428401406 no 701 0.179566845007781 215 1625765 SGTC_95 0471-0001 561.058 µM 0.917016511672667 0.208339572038732 no 702 0.179566993915556 206 4015405 SGTC_1713 st033146 12.748 µM 0.916593151489942 0.208446584034225 no 703 0.179677937212066 193 674619 SGTC_2156 5649887 115 µM 0.916335972925207 0.208511606423284 no 704 0.179745352948405 208 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1671 st016596 74.5 µM 0.914418092155656 0.208996880741882 no 705 0.180248599380953 212 2829167 SGTC_799 1310-0557 151 µM 0.913791826378596 0.209155486424314 no 706 0.180413121063583 207 5354492 SGTC_1915 st067105 30.6 µM 0.910575074081573 0.209971264949439 no 707 0.181259654412559 212 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_554 4483-2211 187 µM 0.910100808305228 0.210091698205495 no 708 0.181384674166425 197 747107 SGTC_1573 oleylamine 1.06 µM 0.909537362405435 0.210234830256366 no 709 0.181533272571896 213 5356789 An amine of the fatty acid oleic acid. SGTC_3067 9117431 49.47 µM 0.908529626315875 0.210490968015627 no 710 0.181799234218039 233 17150885 SGTC_793 0488-0545 106 µM 0.908132001066321 0.210592083379479 no 711 0.181904242477623 220 292548 SGTC_1443 4112-3303 14 µM 0.907842877293806 0.210665624912876 no 712 0.181980620557802 224 704433 SGTC_2525 harmine 47.85 µM 0.906602986562865 0.21098117437463 no 713 0.182308390925875 188 5280953 A monoamine oxidase inhibitor SGTC_3274 9138298 49.47 µM 0.906433287201249 0.211024384036049 no 714 0.182353280353887 220 17015756 SGTC_869 0564-0080 44.1 µM 0.906423437521547 0.211026892167781 no 715 0.182355886035289 173 6843321 SGTC_289 k017-0060 526 µM 0.90630458242991 0.211057158918105 no 716 0.182387330364045 214 5512909 SGTC_2147 5545932 89.7195 µM 0.905904226016342 0.211159129412705 no 717 0.182493273664986 220 797404 SGTC_638 3970-0837 4.09 µM 0.905070570163963 0.211371553591484 no 718 0.182714001056534 183 4118451 YLR208W SEC13 SGTC_1 0258-0098 57.368 µM 0.904450228208089 0.211529704362774 no 719 0.182878357358087 191 6790032 YDR047W HEM12 SGTC_876 0720-0963 56.8 µM 0.900318984401254 0.212584694628773 no 720 0.183975260486415 200 765861 SGTC_2459 5811157 9.22 µM 0.897339965935853 0.213347345931374 no 721 0.184768768258226 213 2870684 YBR192W RIM2 SGTC_1411 3909-8223 150 µM 0.896227869680991 0.213632459368057 no 722 0.185065536881888 217 X1411 SGTC_510 ag-490 170 µM 0.89594630894015 0.213704679641621 no 723 0.185140719768264 198 5328779 SGTC_1313 1220-0047 237 µM 0.895241593648682 0.213885501302509 no 724 0.185328977338434 207 3528706 SGTC_1845 st056753 3.01 µM 0.895226885351524 0.21388927622748 no 725 0.185332907777189 214 5375839 SGTC_2626 ethyl orsellinate 100 µM 0.893496402748171 0.214333680053426 no 726 0.185795698836626 224 75653 A natural product. SGTC_1018 4259-0013 28.1 µM 0.888414983057238 0.215641735004395 no 727 0.187158784378664 210 6801262 SGTC_1701 st028638 40.4 µM 0.888193855382481 0.21569876240962 no 728 0.187218241734342 200 3490878 SGTC_2338 7999974 200 µM 0.888144225250985 0.215711562902617 no 729 0.187231588011533 222 315925 SGTC_202 3594-0513 34.79 µM 0.886244334981364 0.216201909373662 no 730 0.187742938887397 209 708429 SGTC_2304 7443016 91.4 µM 0.88617772520782 0.21621911252566 no 731 0.187760882384816 197 939854 SGTC_2372 9071633 200 µM 0.885537591208261 0.216384478855446 no 732 0.187933377185761 197 21321366 SGTC_2109 5483026 200 µM 0.885110046732493 0.216494967523489 no 733 0.188048640667446 267 759335 SGTC_260 nsc-65238 3.989 µM 0.883920561409934 0.21680253331605 no 734 0.188369548444481 195 3246252 SGTC_3114 9122766 49.47 µM 0.883106094113081 0.217013276158572 no 735 0.188589475920293 179 17176985 SGTC_2128 5255449 168.493 µM 0.882982445153934 0.217045280587667 no 736 0.188622878210002 197 736008 SGTC_565 1418-0001 44.5 µM 0.880010830836138 0.217815252423356 no 737 0.189426721107399 219 2862145 SGTC_432 NS 1619 61.3 µM 0.879348844413697 0.217986993356189 no 738 0.189606079895072 198 4552 A K+/calcium channel activator. SGTC_49 0717-0965 32.132 µM 0.878608951256029 0.218179038208349 no 739 0.189806670352538 230 5889349 YGL099W LSG1 SGTC_2068 5226020 147 µM 0.878182854591041 0.218289679041955 no 740 0.189922247473093 216 1810509 SGTC_547 1120-0019 610 nM 0.877522116994163 0.218461310967164 no 741 0.190101555608233 207 3676939 SGTC_1019 4262-0212 3.4 µM 0.877388040789609 0.218496147826273 no 742 0.190137953326506 221 4677213 SGTC_2803 7707263 71.43 µM 0.876210273972346 0.218802303005162 no 743 0.190457866129771 185 2199229 SGTC_1442 4112-3290 3 µM 0.876115558771018 0.218826934514201 no 744 0.190483607649627 216 704353 SGTC_1402 3909-7673 35.9 µM 0.876001451616392 0.218856611187556 no 745 0.190514622315155 219 5328014 SGTC_2197 6588183 93.1375 µM 0.871955571812732 0.219910348046266 no 746 0.19161630763592 194 884136 SGTC_2137 5261020 140 µM 0.871576528877031 0.220009217544564 no 747 0.191719719834271 190 763655 SGTC_1314 1222-0010 41.1 µM 0.870302325714611 0.220341767394796 no 748 0.1920676041502 208 3526027 SGTC_997 3996-0078 137 µM 0.869369410876128 0.220585428206545 no 749 0.192322554331516 209 735687 SGTC_1896 st058441 89 µM 0.867026133930892 0.221198130971478 no 750 0.192963845347575 202 688759 SGTC_155 k072-0202 43.6 µM 0.866200895911222 0.221414139708115 no 751 0.193190001074918 228 5857737 SGTC_2514 salinomycin 42.74 µM 0.865793705681763 0.221520767497475 no 752 0.193301650772881 225 23682228 A polyether potassium ionophore. SGTC_1681 tripelennamine 100 µM 0.865749310752545 0.221532394632146 no 753 0.193313826039537 191 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1119 parthenolide 318.541 nM 0.86552498392745 0.221591151681074 no 754 0.193375354612008 241 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2949 9072542 2.23 µM 0.865197692601234 0.221676893794409 no 755 0.193465145816315 215 16457352 SGTC_1337 1486-1011 40.3 µM 0.864941887909284 0.221743921400157 no 756 0.193535342623362 219 X1337 SGTC_563 tetrahydrosecaminediol 614 µM 0.864938302672896 0.221744860909336 no 757 0.193536326578664 201 334274 A psychoactive constituent of the cannabis plant. SGTC_2038 4100038 30.985 µM 0.861431580171188 0.222664883886522 no 758 0.194500194558325 221 3596803 SGTC_2523 spermine 47.74 µM 0.85901617034424 0.223299853775762 no 759 0.195165797359567 193 1103 A DNA binding polyamine. SGTC_2444 5485484 36.41 µM 0.857575384356156 0.223679101908077 no 760 0.19556348612065 240 6790631 SGTC_1296 1068-0102 11.9 µM 0.857207222297564 0.223776069375922 no 761 0.195665185861984 210 767053 SGTC_3137 9097352 49.47 µM 0.852987760187372 0.224889107040255 no 762 0.196833045921892 236 44120435 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.852598066615686 0.224992061059475 no 763 0.196941117558068 216 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_158 k038-0087 26.446 µM 0.851554287219483 0.225267951029798 no 764 0.197230760227402 220 X158 SGTC_2153 5569715 200 µM 0.851407520649459 0.225306759475033 no 765 0.197271507746927 224 2054701 SGTC_1214 0358-0031 63.7 µM 0.84903644266804 0.225934251275747 no 766 0.197930507175922 216 4301366 SGTC_611 3453-1652 23.7 µM 0.847767290335853 0.226270530537661 no 767 0.198283791465627 244 1560575 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.847466231351964 0.226350341703695 no 768 0.198367650781556 197 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_124 0136-0217 7.121 µM 0.844946476817456 0.227018955353011 no 769 0.199070361677324 238 3976905 SGTC_3130 9127414 49.47 µM 0.844253150338917 0.227203123832305 no 770 0.199263979849651 217 1494646 SGTC_2170 morpholine 200 µM 0.843929848574317 0.22728903133768 no 771 0.199354303774933 211 121171 Reacts with secondary amines. SGTC_1171 0368-0077 21.4 µM 0.842215215654734 0.227744948152886 no 772 0.199833749203971 227 3239779 SGTC_2726 cimetidine 79.27 µM 0.841651634193824 0.227894915445746 no 773 0.19999148909267 239 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2303 7774051 200 µM 0.84030968077848 0.228252228682365 no 774 0.20036738746322 240 2953184 SGTC_1417 3966-0327 90.4 µM 0.84007478067207 0.228314806381801 no 775 0.200433229620314 218 651118 SGTC_1955 wogonin 32.4 µM 0.838989189825033 0.228604134442379 no 776 0.200737687926541 201 5281703 A flavanone. SGTC_1531 st059297 52.4 µM 0.838513321380171 0.228731026203799 no 777 0.20087123460516 230 7566702 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.838375341237351 0.228767826420705 no 778 0.20090996701838 250 91467 include heat shock SGTC_750 4073-0104 132 µM 0.83821750695389 0.228809925943662 no 779 0.200954278182761 198 22330957 SGTC_2750 bromebric acid 70.15 µM 0.833036991351865 0.230194149093149 no 780 0.202411933602485 215 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_3331 9141060 1.957 µM 0.83291962454244 0.230225563432785 no 781 0.202445030488164 213 4906567 YPR165W RHO1 SGTC_3117 9124945 49.47 µM 0.831669846207163 0.23056022713124 no 782 0.202797662715993 196 17592065 SGTC_3351 9150312 21.596 µM 0.829787486912327 0.23106479508865 no 783 0.20332947340348 240 4904905 SGTC_1393 3470-5649 58.2 µM 0.829755165070653 0.231073464363548 no 784 0.203338612343933 201 4108395 SGTC_2367 9070478 135.38 µM 0.828923103807021 0.231296700009815 no 785 0.203573960475796 220 572802 SGTC_2677 mitomycin C 100 µM 0.828774122906906 0.231336683135076 no 786 0.203616116793741 246 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2472 5377652 49.4 µM 0.827915127068154 0.231567293487741 no 787 0.20385928371492 236 1610903 SGTC_649 1123-0311 367 µM 0.825539488228174 0.232205736222951 no 788 0.204532686765823 231 693629 YIL048W NEO1 SGTC_1399 3562-5772 25 µM 0.825403932660825 0.232242195717593 no 789 0.204571151481363 224 23847490 SGTC_528 3492-0019 172 µM 0.824204641525514 0.232564899935246 no 790 0.204911645082304 241 2869262 SGTC_1847 st056231 15 µM 0.824095551387997 0.232594266179721 no 791 0.204942633833255 236 5393180 SGTC_477 mead ethanolamide 10 µM 0.823785484368739 0.232677745144803 no 792 0.205030728407285 183 16061185 SGTC_551 k048-0028 34.9 µM 0.822340221980364 0.23306707100476 no 793 0.205441645460156 238 6836383 SGTC_1994 st072947 40.9 µM 0.821003174333005 0.233427567772864 no 794 0.205822230050713 234 5286565 YDL195W SEC31 SGTC_1299 1079-1439 3.74 µM 0.820243651935286 0.233632489014844 no 795 0.206038610863498 240 323161 SGTC_276 colchicine 750 µM 0.820071973734096 0.233678822085057 no 796 0.206087539060131 230 2833 A microtubule depolymerizer. SGTC_3011 9081274 71.4286 µM 0.819948833646012 0.233712058668817 no 797 0.206122638162981 231 6625322 SGTC_1247 0448-0043 5.84 µM 0.819819256568693 0.233747035481537 no 798 0.206159575852966 232 3089013 YGL099W LSG1 SGTC_2838 9002687 71.43 µM 0.819224180163308 0.233907702040977 no 799 0.206329260780201 237 6457060 SGTC_542 3381-0244 89.3 µM 0.819190245729928 0.23391686594964 no 800 0.206338939614503 237 1112843 SGTC_3051 9093778 49.47 µM 0.818054134714084 0.234223784664621 no 801 0.206663138322346 263 17217378 SGTC_648 0375-0473 33.3 µM 0.81752239766403 0.234367509198115 no 802 0.206814977472683 238 1713139 SGTC_1950 st077106 7.18 µM 0.816954491903234 0.234521063746011 no 803 0.206977217617884 211 13831864 SGTC_3158 9100007 49.47 µM 0.816409208908787 0.234668553741113 no 804 0.207133065708707 233 19297233 SGTC_1205 4161-2785 76 µM 0.815969790678587 0.234787446386851 no 805 0.207258706938426 219 3498106 SGTC_2925 9010536 32.5 µM 0.8153431262513 0.234957059509049 no 806 0.207437964726361 214 2994177 SGTC_1666 st014829 29 µM 0.81499874162381 0.235050299542542 no 807 0.207536515193656 230 3858230 SGTC_840 0245-0196 390 µM 0.813187844121393 0.235540925152293 no 808 0.208055183892953 213 3827528 SGTC_2810 7959871 45.46 µM 0.812244778749836 0.235796652976948 no 809 0.208325594928691 230 2974535 SGTC_2788 5282734 71.43 µM 0.810609948317622 0.236240326846059 no 810 0.208794850999376 237 743706 SGTC_659 k018-0002 107 µM 0.809307780502167 0.236594048648114 no 811 0.209169065987366 234 6797879 YHR007C ERG11 SGTC_368 fentichlor 4.58 µM 0.80662574403937 0.237323516285836 no 812 0.209941068556098 241 7329 A pesticide. SGTC_1523 st012844 44.7 µM 0.806429211044401 0.237377018394241 no 813 0.209997704764821 200 4274103 SGTC_1014 4130-3005 69.3 µM 0.804909736754768 0.23779088779951 no 814 0.210435884628777 231 743608 SGTC_441 propafenone 146 µM 0.804189228361161 0.237987275746342 no 815 0.210643849377759 253 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1384 3089-0840 101 µM 0.804124143752263 0.238005020143056 no 816 0.210662641083297 212 1069836 SGTC_3355 9151058 44.0485 µM 0.803313141123104 0.238226189333565 no 817 0.21089688218287 230 17015728 SGTC_2650 prasterone 100 µM 0.803189861197201 0.238259818958931 no 818 0.210932502371357 208 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_15 0266-0086 27.098 µM 0.802364923042459 0.238484921381163 no 819 0.211170948666087 254 1712902 YIL048W NEO1 SGTC_3070 9117005 49.47 µM 0.801448794917011 0.238735043370166 no 820 0.211435938212818 221 8779016 SGTC_1568 digitonin 820 nM 0.801428225682227 0.238740660844997 no 821 0.211441890086808 257 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2539 epi(13)torulosol 80 µM 0.801156073503014 0.238814992635398 no 822 0.211520648751811 238 6708597 SGTC_1910 st062352 60.4 µM 0.799737094936062 0.239202757331848 no 823 0.211931567968566 236 2245730 SGTC_3307 9126885 69.2785 µM 0.797977470225404 0.239684087962096 no 824 0.212441782238119 211 24824909 SGTC_1779 st039427 55 µM 0.790028363569497 0.241865072533146 no 825 0.214755601986935 243 1124498 SGTC_911 3456-4043 236 µM 0.789791447910431 0.241930239559417 no 826 0.214824787178514 241 914281 SGTC_1802 st050112 57.9 µM 0.789603228498401 0.241982018778091 no 827 0.214879761098507 240 4662563 SGTC_1255 0566-0045 221 µM 0.789367492448082 0.242046878316449 no 828 0.214948624898932 238 2788469 SGTC_1787 fluconazole 80 µM 0.786035020323762 0.242964770137836 no 829 0.215923485359847 241 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_628 1636-0253 16 µM 0.78551660533476 0.243107730752827 no 830 0.2160753691526 251 4456143 SGTC_2824 7998404 51.95 µM 0.784600766722675 0.243360397942201 no 831 0.216343840191243 256 837851 SGTC_2166 5933061 31.504 µM 0.784097644122145 0.2434992628688 no 832 0.216491408843089 227 2877375 SGTC_2473 5854593 8.94 µM 0.784096079297872 0.243499694836667 no 833 0.216491867905574 245 2872951 SGTC_1256 0570-0116 285 µM 0.783582017766018 0.243641623309289 no 834 0.216642705331244 235 410638 SGTC_1186 1319-0216 26 µM 0.780152794418022 0.24458954762101 no 835 0.217650472099699 250 4565136 SGTC_414 piperonyl butoxide 100 µM 0.780152081451415 0.244589744909384 no 836 0.217650681904408 234 5794 A potent inhibitor of cytochrome P450. SGTC_658 3253-0951 102 µM 0.778837352469751 0.244953695565897 no 837 0.218037765723905 235 1184878 SGTC_2904 7225135 42.03 µM 0.778829445392376 0.244955885328608 no 838 0.218040094933462 285 4446116 SGTC_890 0929-0006 47.2 µM 0.778303478302643 0.245101568754268 no 839 0.218195062715614 224 1378169 SGTC_2428 5615643 7.78 µM 0.776795247703445 0.24551957978643 no 840 0.218639790501322 256 2253075 SGTC_3223 9129970 49.47 µM 0.774066428579539 0.246276853213467 no 841 0.219445754512183 258 17248386 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.774065864729379 0.246277009816577 no 842 0.219445921223022 231 5379071 SGTC_962 1254-0300 21.5 µM 0.773075527429839 0.246552147361196 no 843 0.219738841720103 221 7340576 SGTC_1760 st045453 10.4495 µM 0.772241896452379 0.246783876016864 no 844 0.219985585765015 267 3323419 YIL048W NEO1 SGTC_1659 st012954 42.1 µM 0.7714687418201 0.246998897931252 no 845 0.22021457161478 246 24207262 SGTC_1117 retinoic acid 1.10837 µM 0.768861283166427 0.247724796336711 no 846 0.220987831819272 246 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1013 4112-3890 241 µM 0.768152248491928 0.247922383492028 no 847 0.221198369483633 264 705171 SGTC_2800 7887935 81.82 µM 0.768057784239713 0.247948714254759 no 848 0.221226427946363 245 2961002 SGTC_2150 5556613 200 µM 0.766086320691009 0.24849857618108 no 849 0.221812470906281 256 743190 SGTC_2130 NSC 7 2.4545 µM 0.765795429234743 0.248579763842526 no 850 0.221899017155875 234 21448 SGTC_3144 9087057 49.47 µM 0.765585194340997 0.248638449092899 no 851 0.221961578406479 237 17249618 SGTC_1006 4099-6547 255 µM 0.764741144800703 0.24887413248247 no 852 0.222212850227732 268 3146833 SGTC_2618 avocadyne 43.43 µM 0.76422579894855 0.249018090607692 no 853 0.222366347409288 253 3015189 SGTC_2144 5628481 200 µM 0.764176843253989 0.249031768329854 no 854 0.222380932142827 242 2818399 SGTC_1970 st070122 35.8 µM 0.763270624841705 0.249285028686404 no 855 0.222651008529263 266 102928 SGTC_2984 9022109 38.96 µM 0.761782907036906 0.2497010971175 no 856 0.223094791857522 283 6459207 SGTC_55 0767-0285 6.563 µM 0.760602277210115 0.250031544865695 no 857 0.223447329600148 274 3116166 SGTC_644 1498-1197 63.3 µM 0.759280352197489 0.250401815037374 no 858 0.223842434117687 247 6741615 SGTC_3353 9151644 39.2805 µM 0.758262048425655 0.250687239182816 no 859 0.224147061135081 231 4909158 SGTC_3046 9092212 49.47 µM 0.757802026644031 0.250816236875948 no 860 0.224284754472224 271 25236637 SGTC_3344 9148862 3.898 µM 0.757773456571143 0.250824249554393 no 861 0.224293307626222 260 4905352 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.757321427545986 0.250951042314441 no 862 0.224428658272701 245 97141 SGTC_730 1436-0052 41.2 µM 0.756830649408831 0.251088742478927 no 863 0.224575664002613 220 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2024 5144227 134 µM 0.756483896048212 0.251186056957887 no 864 0.224679562049652 235 3475211 SGTC_1429 4049-0205 9.46 µM 0.755744518897354 0.251393625801253 no 865 0.224901193363622 234 22774478 SGTC_2906 7926292 26.41 µM 0.755737836934498 0.251395502073566 no 866 0.224903196874114 261 2966319 SGTC_3349 9149703 23.001 µM 0.755443814023582 0.251478070029196 no 867 0.224991366313439 236 4910494 SGTC_3026 9090633 49.47 µM 0.754836879080606 0.25164855572424 no 868 0.225173431464532 258 25236842 SGTC_1341 1486-1360 280 µM 0.753665536097866 0.251977753989239 no 869 0.225525040624632 270 3976547 SGTC_1275 0867-0008 21.1 µM 0.752687797345606 0.252252714969964 no 870 0.225818772221279 244 3422836 SGTC_1575 cyproterone acetate 48 µM 0.750189327783365 0.252956055915232 no 871 0.226570342742352 257 9880 An androgen receptor antagonist and liver toxin. SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.748663295850334 0.253386154319686 no 872 0.227030085754182 253 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_3222 9128301 49.47 µM 0.748309035432265 0.253486054382638 no 873 0.22713688789606 243 4911358 SGTC_598 3937-0236 20.2 µM 0.747064511195782 0.253837169380423 no 874 0.227512310478995 276 1379313 SGTC_2782 7736369 71.43 µM 0.745785510769835 0.254198276900719 no 875 0.22789849698259 268 2950836 YOL077C BRX1 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.745154856629578 0.254376432210643 no 876 0.228089054896924 273 442882 SGTC_2121 5257820 149.641 µM 0.742419370599552 0.255149944468573 no 877 0.228916643437232 238 791256 SGTC_1144 3486-0183 12.5 µM 0.741806365141713 0.255323452329436 no 878 0.229102331752698 270 6744069 SGTC_1754 st042065 16.137 µM 0.740253290577284 0.25576331754969 no 879 0.229573158720121 261 1126236 YIL048W NEO1 SGTC_1493 4348-0038 111 µM 0.73991902305078 0.255858041249119 no 880 0.229674565439483 279 800424 SGTC_3037 9091026 49.47 µM 0.739530218965369 0.255968242379886 no 881 0.229792548467854 260 25236398 YIL048W NEO1 SGTC_2008 4012253 172 µM 0.739503485667147 0.255975820472673 no 882 0.229800661963401 248 603940 SGTC_629 3448-6466 76.7 µM 0.739303515642486 0.256032509723352 no 883 0.229861357500792 270 573744 SGTC_1436 4092-1007 8.32 µM 0.738456742520438 0.256272632932851 no 884 0.230118472211067 225 2881121 SGTC_1559 coumarin 343 70.1 µM 0.738012212822208 0.256398737165996 no 885 0.230253513862019 262 108770 A hepatotoxic, DNA x-linker. SGTC_1347 1493-0251 600 nM 0.73359359917238 0.257653965890332 no 886 0.231598231596909 247 3986378 SGTC_3149 9097855 49.47 µM 0.732309634992726 0.258019308586325 no 887 0.231989799907669 237 25236625 YMR079W SEC14 SGTC_2168 5727979 200 µM 0.728663992619638 0.259058112333716 no 888 0.233103611834024 253 695210 SGTC_1287 0971-0001 34.6 µM 0.72865801765418 0.259059816637408 no 889 0.23310543973144 252 4665869 SGTC_1477 0139-0234 16 µM 0.727729860206511 0.259324635361127 no 890 0.23338948386485 256 620880 SGTC_75 0159-0059 199.013 µM 0.723226885562836 0.26061139132185 no 891 0.234770251831777 283 5377270 SGTC_469 w7 172 µM 0.722457313088701 0.260831630334569 no 892 0.235006680426431 251 45115570 A P450 inhibitor. SGTC_3273 9137859 49.47 µM 0.720734293544877 0.261325077180532 no 893 0.235536504351867 299 2377234 SGTC_1945 st075991 56.6 µM 0.720657592586188 0.261347054322878 no 894 0.235560105004203 247 1084980 SGTC_1594 piperine 70.1 µM 0.719484819300242 0.261683207499015 no 895 0.235921126218238 252 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_798 1287-0182 476 µM 0.718879433153266 0.261856816715936 no 896 0.236107604822114 278 1649755 SGTC_1188 1403-0014 4.57 µM 0.717540460264599 0.262241009494982 no 897 0.236520340244903 255 9614867 SGTC_285 1486-1325 46 µM 0.716307114028237 0.262595150039428 no 898 0.236900867517162 265 22310230 SGTC_2777 climbazole 1.536 µM 0.71617679451602 0.262632584012024 no 899 0.236941094959955 270 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_3068 9116768 49.47 µM 0.713748691725126 0.263330549860205 no 900 0.237691295810642 263 41904888 SGTC_3172 9105863 49.47 µM 0.712775018044728 0.263610701273026 no 901 0.237992493380498 267 2348785 SGTC_3116 9124943 49.47 µM 0.711148237092202 0.264079107786826 no 902 0.238496190532343 246 41905195 YPL160W CDC60 SGTC_3175 9106517 49.47 µM 0.710164978172681 0.264362427515544 no 903 0.23880091790679 271 41468073 SGTC_671 0560-0003 407 µM 0.709752386617944 0.264481359187084 no 904 0.238928849914107 241 3238678 SGTC_1336 1486-0901 104 µM 0.707146224324362 0.265233227731475 no 905 0.239737806417126 258 5006114 SGTC_956 1185-0240 191 µM 0.70671808188251 0.265356849007135 no 906 0.239870845225335 263 1416193 SGTC_1349 flufenamic acid 69 µM 0.705935699164153 0.265582828668589 no 907 0.240114062857068 272 3371 A non-steroidal anti-inflammatory. SGTC_291 SEC14.278 35.5 µM 0.703823905007369 0.266193276045672 no 908 0.240771222372085 269 1068044 SGTC_2195 6536160 144.242 µM 0.703813727396352 0.26619621976359 no 909 0.240774391864054 255 3834386 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.702070974570413 0.266700527195583 no 910 0.24131745123585 272 75037 A free radical scavenger. SGTC_792 4534-1957 155 µM 0.700327965960346 0.26720539124699 no 911 0.241861255318175 266 1717904 SGTC_1344 1488-0097 29.1 µM 0.700091499486472 0.267273921119435 no 912 0.241935082063525 290 747966 SGTC_491 tetrandrine 80.3 µM 0.6987961186737 0.267649490121898 no 913 0.242339727251833 280 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_294 k038-0071 157 µM 0.698318586995506 0.267788007675386 no 914 0.242488988897003 274 24152826 SGTC_236 1509-0011 5.31 µM 0.698295134320529 0.267794811520201 no 915 0.242496320761076 305 3107280 SGTC_184 1494-0393 24.714 µM 0.697494609036392 0.26802710375464 no 916 0.242746655992297 280 3090647 SGTC_288 1315-0019 35.1 µM 0.696300921926025 0.268373669937529 no 917 0.243120197973035 280 6811474 SGTC_2267 7931562 200 µM 0.695888526887239 0.268493453985033 no 918 0.243249321465509 258 934880 SGTC_311 1315-0136 58 µM 0.695177762651019 0.268699965256511 no 919 0.243471953214882 262 6759207 SGTC_146 3448-8650 53.125 µM 0.694955183426111 0.268764651654687 no 920 0.243541694039824 288 2891488 YIL048W NEO1 SGTC_3304 9125678 46.087 µM 0.693056120326871 0.269316878882619 no 921 0.244137166656722 270 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_970 1315-0089 19.5 µM 0.689727788736838 0.270286092596303 no 922 0.24518269355047 261 6811083 YLR033W RSC58 SGTC_1819 st053448 58.6 µM 0.689540251533097 0.270340755484861 no 923 0.245241676072948 304 2857616 SGTC_741 4582-0002 126 µM 0.687540822456727 0.270923887532489 no 924 0.245870992567176 283 2912688 SGTC_179 1273-0063 6.77 µM 0.682814642993183 0.272304764839017 no 925 0.247361987835116 280 3108139 SGTC_17 0960-0276 49.807 µM 0.676705087245831 0.274094998429416 no 926 0.249296544051207 274 6821114 SGTC_2732 terfenadine 20 µM 0.674572406735882 0.274721286876892 no 927 0.249973734420275 295 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1881 5652484 16 µM 0.674231681894302 0.274821410343535 no 928 0.250082015197305 288 2255129 SGTC_2300 7976697 71.57 µM 0.674204972849495 0.274829259671935 no 929 0.250090504259677 265 2236109 SGTC_732 3970-1727 52.7 µM 0.673097906008261 0.275154704738224 no 930 0.250442503007892 283 1275699 SGTC_2484 5809818 12.04 µM 0.672616005800148 0.27529642847219 no 931 0.25059580814193 268 2870548 SGTC_2263 7948595 193.29 µM 0.671374911818601 0.275661591519483 no 932 0.250990861561866 274 2971371 SGTC_2589 lobaric acid 100 µM 0.669999480842627 0.27606655808422 no 933 0.251429060570074 282 73157 A novel microtubule depolymerizer. SGTC_928 2764-0428 58.7 µM 0.66062191248162 0.278835343696342 no 934 0.254427406427834 288 662578 SGTC_2966 9084041 48.03 µM 0.659152036541219 0.279270555740181 no 935 0.25489907156957 268 17741380 SGTC_118 0083-0097 135.343 µM 0.658808866301961 0.279372211704097 no 936 0.255009256539097 315 5207356 SGTC_2807 7945238 51.95 µM 0.657289486181964 0.279822507530156 no 937 0.255497397768234 290 17148797 SGTC_2708 st078559 56 µM 0.656904686033108 0.279936605874438 no 938 0.255621102468829 260 17250902 SGTC_1502 4534-4282 27.7 µM 0.656297032645141 0.280116829085255 no 939 0.255816513217691 298 3278949 SGTC_1511 0906-3109 28.5 µM 0.655001770262401 0.280501177012552 no 940 0.256233307146399 277 2882180 SGTC_140 0062-0056 502.533 µM 0.653690336298777 0.280890583455895 no 941 0.256655665229904 271 3758964 SGTC_940 3232-1287 54.8 µM 0.65297195605474 0.281104004115164 no 942 0.256887179075019 290 1585493 YIL048W NEO1 SGTC_2297 7971671 152.32 µM 0.651804608220429 0.281450973696109 no 943 0.257263614246555 284 909016 SGTC_258 haloperidol 50.781 µM 0.651021349533334 0.281683896642343 no 944 0.257516352665945 304 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2940 9060638 45.86 µM 0.650416146956236 0.281863933460862 no 945 0.257711725021516 282 4027022 SGTC_2374 9071832 200 µM 0.648007454014727 0.282581025000399 no 946 0.258490064578428 280 17381698 SGTC_88 0180-0332 8.668 µM 0.647909148571401 0.282610310112935 no 947 0.258521856616607 286 3101745 SGTC_1766 st045414 44.774 µM 0.647877557446069 0.282619721393488 no 948 0.258532073635058 308 253960 SGTC_2643 anethole 100 µM 0.646875342982534 0.282918368269933 no 949 0.258856312539202 314 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1229 0139-0193 12.2 µM 0.646601830850402 0.28299989764123 no 950 0.258944836392524 298 3090752 SGTC_2480 5767542 37.17 µM 0.645611572203689 0.283295171406978 no 951 0.259265470517802 287 2867358 SGTC_3256 9138902 49.47 µM 0.645385674810042 0.283362549827227 no 952 0.259338642172483 320 17228773 SGTC_1354 1498-1681 81 µM 0.643521157712563 0.28391897261325 no 953 0.259942995283998 283 5754243 SGTC_1355 1499-0035 1.68 µM 0.641380190403117 0.28455853992112 no 954 0.260637850109784 295 1548538 SGTC_627 1391-0720 175 µM 0.637198573889578 0.2858096872134 no 955 0.26199775324951 324 997839 SGTC_1710 st031758 61.5 µM 0.636986479192773 0.28587321598168 no 956 0.262066825349054 294 5394341 SGTC_393 acivicin 6.25 µM 0.633739986022743 0.286846475680421 no 957 0.26312526243773 286 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2350 9023895 38.85 µM 0.6317891034523 0.287432081187741 no 958 0.263762347407087 300 2997209 SGTC_423 5-fluorouracil 457 µM 0.628892685806833 0.288302553826841 no 959 0.2647096574099 293 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_371 0195-0006 7.36 µM 0.628842659932357 0.288317599229042 no 960 0.264726034191127 281 3928593 SGTC_2531 methyl deoxycholate 70.07 µM 0.628161283161174 0.288522561788228 no 961 0.264949145213507 302 16667744 Haematoxylin. SGTC_3261 9137475 49.47 µM 0.627939895787507 0.288589171323349 no 962 0.265021657185795 250 17027690 SGTC_1508 1080-0625 72.9 µM 0.627753838787697 0.288645156496597 no 963 0.265082605043012 294 767111 SGTC_2231 micatex 6.853 µM 0.626921626585033 0.288895634523825 no 964 0.265355305125803 298 20737 An antifungal of unknown mechanism. SGTC_1248 0469-0687 58.6 µM 0.625664142064769 0.289274304334695 no 965 0.265767628788598 293 4017482 SGTC_2370 9071495 200 µM 0.624969240471835 0.289483662011474 no 966 0.265995623222282 315 21791103 SGTC_2293 7624732 200 µM 0.623642894585562 0.28988345657498 no 967 0.266431066863041 284 894453 SGTC_2211 7117706 200 µM 0.621221205888963 0.290614082769843 no 968 0.267227044326204 288 822771 SGTC_3203 9113543 49.47 µM 0.620129659539395 0.290943684959602 no 969 0.2675862133439 289 17018012 SGTC_409 arachidonic acid 100 µM 0.619461896164632 0.291145408170021 no 970 0.267806058163854 296 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2743 auranofin 4.32 µM 0.619288691648406 0.291197741817498 no 971 0.267863096389 255 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_90 0870-0863 4.608 µM 0.615886159432569 0.292226704465182 no 972 0.268984828454846 322 1738164 SGTC_1547 harmine 94.2 µM 0.613473721391063 0.29295727514195 no 973 0.269781576700929 296 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1378 2093-0007 380 nM 0.611951457660029 0.293418705569004 no 974 0.270284937320369 319 3618014 SGTC_2366 9070441 60.58 µM 0.610959994205723 0.293719420122249 no 975 0.270613032739167 284 6837235 SGTC_1912 st060209 90.8 µM 0.607804700473789 0.294677380364374 no 976 0.271658505698302 319 688787 SGTC_2100 5377183 190 µM 0.607679795649819 0.29471533162011 no 977 0.271699932919656 292 2844202 SGTC_3246 9135460 32.98 µM 0.606355618988743 0.295117809842989 no 978 0.272139316297301 307 41446951 SGTC_2653 dihydrofissinolide 100 µM 0.606302181776902 0.295134057182745 no 979 0.272157055046255 299 6857746 SGTC_3179 9107801 49.47 µM 0.606288326284738 0.295138269948984 no 980 0.272161654539805 265 4818259 SGTC_1797 st048695 56.8 µM 0.605151786247212 0.295483929513422 no 981 0.272539073892607 318 592262 YIL048W NEO1 SGTC_2712 st079126 47.7 µM 0.604647629564645 0.295637319890316 no 982 0.272706576133499 299 3152970 SGTC_91 0417-1751 58.384 µM 0.604613567858851 0.295647684531839 no 983 0.272717894719375 302 6795624 SGTC_3197 9113331 49.47 µM 0.603972007505185 0.295842936218512 no 984 0.272931126518122 285 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2512 diallyl trisulfide 49.23 µM 0.603398615012365 0.296017491888641 no 985 0.273121771686204 325 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1317 1273-0028 910 nM 0.601291379388828 0.29665939527724 no 986 0.273822965154209 301 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1818 st052136 56.3 µM 0.599689893848927 0.297147663655559 no 987 0.274356462361505 291 674169 SGTC_97 0535-0701 19.132 µM 0.59878565686524 0.297423513829046 no 988 0.274657914110055 300 2832013 YGL099W LSG1 SGTC_817 1391-0715 46 µM 0.598564085777855 0.297491125033114 no 989 0.274731805708918 331 1353946 SGTC_826 1683-5028 118 µM 0.597433820145015 0.297836128557723 no 990 0.275108889724687 312 722377 SGTC_1162 k048-0130 20.1 µM 0.596822290624062 0.298022868536843 no 991 0.275313017006505 315 6797406 SGTC_1016 4226-1401 38 µM 0.596410659434302 0.298148596513638 no 992 0.275450460603747 308 2901613 SGTC_357 1325-0123 420 µM 0.596129899041073 0.298234365379966 no 993 0.275544225819606 320 1098503 SGTC_2204 7233102 200 µM 0.594796996163463 0.298641704109621 no 994 0.275989587856662 304 2172480 SGTC_1004 4084-0029 199 µM 0.593939634198517 0.298903849872727 no 995 0.276276244401772 308 716894 YLR208W SEC13 SGTC_2956 9076196 2.52 µM 0.593571612076193 0.299016407845514 no 996 0.276399336352688 326 16423868 SGTC_370 0180-0345 38.7 µM 0.593157447612219 0.299143101266895 no 997 0.276537893641876 289 3989527 SGTC_2505 galangin 7.89 µM 0.592979410949164 0.299197570389089 no 998 0.27659746565506 327 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_427 1354-0053 47.3 µM 0.592304941787684 0.299403960512132 no 999 0.276823203654878 318 6813657 SGTC_2721 ifenprodil 61.44 µM 0.59193312828028 0.299517764453549 no 1000 0.276947684442986 302 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1825 st052143 62.6 µM 0.591923349726098 0.299520757718625 no 1001 0.276950958610314 309 674173 SGTC_2617 dihydrotanshinone i 20.83 µM 0.591198368107685 0.299742716028096 no 1002 0.27719375802009 287 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_196 k015-0023 18.111 µM 0.589478573211664 0.300269541250464 no 1003 0.27777014077654 303 5211998 SGTC_3328 9140624 29.0385 µM 0.589332720877264 0.300314239481445 no 1004 0.277819049543288 306 4904392 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.589187142671034 0.300358856700953 no 1005 0.277867870578758 328 65057 A dermal irritant. YDR527W RBA50 SGTC_1400 3771-8998 51.5 µM 0.588728842133958 0.300499337496923 no 1006 0.278021593361173 287 670767 SGTC_618 k072-0232 33.2 µM 0.58803421770479 0.300712314142216 no 1007 0.278254662781636 317 5872756 YGL099W LSG1 SGTC_424 splitomicin 100 mM 0.586161620950371 0.301286804292551 no 1008 0.278883454941681 322 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_107 0358-0022 2.6945 µM 0.585807301461689 0.301395560831405 no 1009 0.279002508276623 335 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2069 5228469 200 µM 0.585240812200323 0.301569478490873 no 1010 0.279192903183352 331 2835210 SGTC_2175 5807670 165.306 µM 0.584468883827068 0.301806540582743 no 1011 0.279452447020807 281 241186 SGTC_2092 5303694 80.6725 µM 0.584193817441924 0.301891034735498 no 1012 0.279544960316379 307 1963699 SGTC_2349 9023730 187.07 µM 0.584071732212742 0.301928539953389 no 1013 0.279586026102394 311 4126287 SGTC_1504 k297-0033 30 µM 0.583443945981004 0.302121432200752 no 1014 0.279797240677805 268 4388117 SGTC_3002 9075603 71.4286 µM 0.581088303770004 0.302845714511515 no 1015 0.280590470556288 318 20105405 SGTC_2423 st077119 87.2 µM 0.580853024455565 0.30291809782666 no 1016 0.28066975733497 287 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2873 9040596 71.43 µM 0.580732741612554 0.302955105647463 no 1017 0.280710295637731 343 6463863 SGTC_233 rapamycin 362 pM 0.580150039964195 0.303134416032749 no 1018 0.280906720633263 294 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2581 avocatin a 64 µM 0.579566124981643 0.303314147387982 no 1019 0.281103621257088 325 6710728 A skin care supplement. SGTC_1152 3909-8331 15.9 µM 0.579185563012347 0.303431311507363 no 1020 0.281231985555819 331 16001939 SGTC_3178 9107506 49.47 µM 0.577508479349635 0.303947878191433 no 1021 0.281798006113902 306 8897194 SGTC_2002 4023503 131 µM 0.577348361541813 0.303997217355144 no 1022 0.281852075033352 342 4736863 YCR052W RSC6 SGTC_808 0711-0032 135 µM 0.57682240057492 0.304159313608405 no 1023 0.2820297178157 307 4252555 SGTC_1844 rapamycin 4 nM 0.576477589512358 0.304265602048631 no 1024 0.282146206656043 300 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1916 st067606 49.2 µM 0.573433340208198 0.305204712460008 no 1025 0.283175660745853 306 19590279 SGTC_1957 st077035 62.4 µM 0.570322905177884 0.306165566591104 no 1026 0.284229354128452 321 705593 SGTC_1273 0849-0096 14.1 µM 0.569956633593709 0.306278800660246 no 1027 0.284353555830836 321 5286025 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.568711374657647 0.306663914933172 no 1028 0.284776013642198 299 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1166 k206-0078 225 µM 0.568412662318644 0.306756327801897 no 1029 0.284877397218966 302 5404595 SGTC_1257 0669-0121 16 µM 0.566645766163196 0.307303204912699 no 1030 0.285477437252682 326 4307855 SGTC_1704 st028805 70.8 µM 0.566435460658926 0.307368325750908 no 1031 0.285548897305235 316 2876101 SGTC_2576 guaiol 23.12 µM 0.565709516845993 0.307593160005598 no 1032 0.285795632343132 286 227829 SGTC_948 3448-0295 75.3 µM 0.563842790522485 0.308171641278434 no 1033 0.286430563680296 310 678569 SGTC_2980 9014342 25.29 µM 0.563034053512704 0.308422409544546 no 1034 0.286705847821252 316 2996599 SGTC_861 0443-0273 110 µM 0.559913371157338 0.309390889120839 no 1035 0.287769263967597 327 6149169 SGTC_1736 st036774 51 µM 0.559408406526207 0.309547725749337 no 1036 0.287941512724613 311 1272247 SGTC_534 k292-0788 63.4 µM 0.559399016738838 0.309550642445753 no 1037 0.287944716140993 351 4146317 SGTC_330 1488-0319 80.1 µM 0.558388470816845 0.309864612676857 no 1038 0.288289571924133 322 6846614 SGTC_936 3005-4620 401 µM 0.55194412834554 0.311870084809398 no 1039 0.290493316667236 353 777207 SGTC_251 melphalan 456.522 µM 0.549267958408639 0.31270455241027 no 1040 0.291410786477145 337 460612 A DNA alkylator. SGTC_1711 st032263 62.8 µM 0.548581617503359 0.312918718192047 no 1041 0.291646301968602 332 3958979 SGTC_2511 berberine 10.47 µM 0.547836901638751 0.31315117073115 no 1042 0.291901948949089 327 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_514 4466-0038 2.65 nM 0.547325811688532 0.313310743225379 no 1043 0.292077456907795 289 5722064 SGTC_1469 k284-2957 126 µM 0.546527720021213 0.313559993299518 no 1044 0.292351619262622 320 23884841 SGTC_1799 st045822 46.1415 µM 0.546254536292437 0.313645330214587 no 1045 0.292445491473643 339 3674992 SGTC_2945 9067681 61.76 µM 0.546041360858708 0.313711928714281 no 1046 0.292518753186225 341 16456930 SGTC_1926 methyl fluorone black 53.6 µM 0.545968709962904 0.313734627091361 no 1047 0.292543722969819 293 72721 Reacts with homocysteine. SGTC_781 4335-2806 94.4 µM 0.544504225621491 0.314192327356554 no 1048 0.293047270685271 346 845254 SGTC_1027 k015-0025 8.67 µM 0.544423018537331 0.314217715654492 no 1049 0.293075204658749 317 3598955 SGTC_1359 1582-0056 520 nM 0.543953672787265 0.314364467482289 no 1050 0.293236676486514 333 3661189 SGTC_1526 st051518 75 µM 0.543166039413526 0.314610805244891 no 1051 0.293507743347469 325 673993 SGTC_2863 9028737 58.44 µM 0.543111084669075 0.314627995801474 no 1052 0.293526660550782 330 6460917 SGTC_1343 1487-0095 224 µM 0.542940289737967 0.314681425235292 no 1053 0.293585457303119 349 4560101 YGL055W OLE1 SGTC_2073 5212005 126 µM 0.541573854057407 0.315109024182447 no 1054 0.294056053776025 354 691789 SGTC_2455 5377712 9.75 µM 0.540245422811443 0.315524968047772 no 1055 0.294513895620635 297 2243908 SGTC_66 0109-0187 42.4 µM 0.539743650282735 0.315682138447465 no 1056 0.294686916330329 309 759417 SGTC_2900 5328528 85.29 µM 0.537630193702127 0.316344502942396 no 1057 0.295416190397391 310 795359 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.537040615974801 0.316529383890469 no 1058 0.295619779417015 308 4174840 SGTC_1962 st076595 64.5 µM 0.53640819777791 0.316727749810195 no 1059 0.295838233487721 330 279619 SGTC_899 1083-0020 478 µM 0.535412499107126 0.317040170030148 no 1060 0.296182324488317 348 767123 SGTC_2790 5423970 71.43 µM 0.533156155638414 0.317748625147215 no 1061 0.296962744531613 331 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1453 4237-0541 195 µM 0.532630239101067 0.31791385043536 no 1062 0.297144782704195 306 739892 SGTC_787 4152-0075 138 µM 0.529498518146896 0.318898481662074 no 1063 0.298229836064014 318 9566539 SGTC_968 1309-0633 340 µM 0.529430580283405 0.318919855924363 no 1064 0.298253394609668 332 3761976 SGTC_2571 chrysanthemic acid 100 µM 0.528888789770305 0.319090332824336 no 1065 0.298441299492308 343 2743 An insecticide. SGTC_999 SEC7.066 22.7 µM 0.52573988786846 0.320081906052308 no 1066 0.299534472793373 336 740511 YDR170C SEC7 SGTC_3239 9133757 49.47 µM 0.52484844898448 0.320362849598262 no 1067 0.299844274160819 358 17036923 SGTC_549 1661-1316 519 µM 0.523110170728079 0.320910976924521 no 1068 0.300448794074184 350 2857282 SGTC_344 k064-0035 6.43 µM 0.522064347844659 0.32124094213705 no 1069 0.300812764280918 344 5088750 SGTC_590 k048-0076 22.4 µM 0.521281026451458 0.321488178576992 no 1070 0.301085508199438 340 6832814 SGTC_786 4544-0069 423 µM 0.519569639180018 0.322028611630123 no 1071 0.301681781848693 326 748821 YLR208W SEC13 SGTC_3088 9117578 49.47 µM 0.518970953430757 0.322217757497562 no 1072 0.301890498473633 331 678341 SGTC_2051 5263410 176 µM 0.518046359778775 0.322509959582933 no 1073 0.30221296204508 326 227584 SGTC_206 4546-0025 72.014 µM 0.517729577449842 0.322610098479486 no 1074 0.302323479378062 342 6620745 YIL048W NEO1 SGTC_250 brefeldin a 552.239 µM 0.51743519042011 0.3227031694752 no 1075 0.302426199808603 336 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.514242001172742 0.323713414758649 no 1076 0.303541402983517 322 6708514 SGTC_254 nsc-64875 3.808 µM 0.512280015033506 0.324334783638563 no 1077 0.304227525009898 331 56993 SGTC_1620 st003704 16.5 µM 0.510057606495389 0.325039220596243 no 1078 0.305005552106463 329 2834414 SGTC_878 0828-0289 13.7 µM 0.509157623319927 0.325324666515305 no 1079 0.30532087196591 335 745350 YLR208W SEC13 SGTC_3268 9137683 49.47 µM 0.507745681303148 0.325772695950435 no 1080 0.305815853875907 368 1953228 SGTC_984 1492-0255 2.91 µM 0.507234532222991 0.325934952978379 no 1081 0.305995134021954 346 1585198 SGTC_2999 9069765 71.4286 µM 0.506582007743955 0.32614213552849 no 1082 0.306224067646131 310 2097066 SGTC_1385 3091-4834 14.1 µM 0.50653323483708 0.326157623533602 no 1083 0.30624118231846 334 4072814 SGTC_2225 6654152 15.4 µM 0.506357140279992 0.32621354546425 no 1084 0.306302978353767 352 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_874 0599-0792 117 µM 0.505112006084184 0.326609071216564 no 1085 0.306740084594935 350 765305 SGTC_1509 1326-1131 80 µM 0.504107542097991 0.326928288480473 no 1086 0.307092903622099 321 768313 SGTC_1335 1486-0900 202 µM 0.503356581101126 0.327167025626698 no 1087 0.307356796213551 325 X1335 SGTC_816 0325-0417 81.3 µM 0.502445738845739 0.327456685357859 no 1088 0.307677006005057 346 68101 SGTC_246 cycloheximide 667 µM 0.501470363126203 0.327766982782827 no 1089 0.308020065279769 331 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2680 butyl paraben 22.24 µM 0.501453179865749 0.327772450380655 no 1090 0.308026110483543 352 7184 An antifungal and steroid mimetic. SGTC_1866 st057638 64 µM 0.50102106591638 0.327909958267652 no 1091 0.308178148630995 328 688802 SGTC_1179 1021-1431 9.29 µM 0.500580560204256 0.328050160610721 no 1092 0.308333173282496 365 2840958 SGTC_2819 7996655 46.38 µM 0.500559775205787 0.328056776573191 no 1093 0.30834048887273 342 6456960 SGTC_2062 5245942 200 µM 0.499922060513417 0.328259790360929 no 1094 0.308564979051439 339 1376160 SGTC_1213 1315-0166 115 µM 0.49954521110279 0.328379782635643 no 1095 0.308697672328228 324 768401 SGTC_1052 3253-3998 198 µM 0.49799426300722 0.328873804859463 no 1096 0.309244042908343 317 5450317 SGTC_177 1327-0068 8.361 µM 0.497528309558162 0.329022283101084 no 1097 0.309408272277864 319 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_580 1123-0028 41 µM 0.496603693545475 0.329316996181487 no 1098 0.309734274000311 341 1677248 YPR107C YTH1 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.495909238174669 0.329538417386387 no 1099 0.309979224001007 369 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_3085 9117376 49.47 µM 0.494126993284713 0.330106944457434 no 1100 0.310608247693073 336 16480349 SGTC_2462 5162487 171.77 µM 0.493276178805149 0.330378488467226 no 1101 0.310908728811425 361 2259986 SGTC_3066 9117245 49.47 µM 0.490981962428203 0.33111115026621 no 1102 0.311719602590434 325 17176980 SGTC_164 4100-3994 89.624 µM 0.489676190482979 0.331528439868743 no 1103 0.312181526317722 373 4615967 SGTC_1290 0986-0249 10.2 µM 0.487724876815676 0.332152417033987 no 1104 0.312872364308793 344 53329 SGTC_1934 st074720 32.6 µM 0.487505671201226 0.332222542166286 no 1105 0.312950012426275 334 17250992 SGTC_1977 st070720 65.3 µM 0.487459578911135 0.33223728810165 no 1106 0.312966340525536 323 682188 SGTC_3153 9100258 49.47 µM 0.486113596522598 0.332668011867653 no 1107 0.313443313696539 370 25236848 SGTC_855 0428-0020 25 µM 0.486082152187337 0.332678076918209 no 1108 0.31345446029904 330 6812414 SGTC_2772 vinpocetine 57.06 µM 0.484742769074935 0.333106913375498 no 1109 0.313929412041598 387 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_3098 9119039 49.47 µM 0.483990707779126 0.333347800050656 no 1110 0.314196231891477 336 17161528 SGTC_2937 9044753 11.33 µM 0.481540171605675 0.334133188024019 no 1111 0.315066317985951 340 6465530 YGL099W LSG1 SGTC_1664 st014217 9.02 µM 0.481124592700535 0.334266451736941 no 1112 0.315213975209514 363 3982782 SGTC_389 tpck 16.7 µM 0.480241094523644 0.33454983255593 no 1113 0.315527984531074 328 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1472 k841-0093 193 µM 0.479969388600732 0.334637000818816 no 1114 0.315624579944361 355 X1472 SGTC_1135 dihydrocapsaicin 536.708 nM 0.479436615149259 0.334807950222646 no 1115 0.31581402523183 379 107982 A Capsaicinoid. SGTC_2948 9070189 9.45 µM 0.476776127577934 0.335662124613114 no 1116 0.316760773341934 333 6473636 YDL196W YDL196W SGTC_1078 idebenone 36.1 µM 0.476407155379991 0.335780653787591 no 1117 0.316892168986999 354 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_138 0850-0259 40.9225 µM 0.47616325285841 0.335859014364715 no 1118 0.316979038427778 338 6813004 SGTC_2066 5222451 176 µM 0.475120340938577 0.336194159748965 no 1119 0.31735060047742 336 2281147 SGTC_3322 9139058 2.11 µM 0.474881548547435 0.336270915308542 no 1120 0.317435701838924 316 4908926 YPR165W RHO1 SGTC_1888 azatryptophan 97.5 µM 0.474028459408917 0.336545181341502 no 1121 0.317739806435512 320 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_729 4092-0585 94.1 µM 0.473032994332963 0.336865330847573 no 1122 0.318094819929892 341 2169061 SGTC_1805 st050013 60.3 µM 0.471984330653201 0.337202717332544 no 1123 0.31846898653252 350 4037144 SGTC_967 1306-0166 352 µM 0.471898430758644 0.337230359706128 no 1124 0.31849964410622 357 4437607 SGTC_880 0833-0487 87.2 µM 0.470336143566174 0.337733253050796 no 1125 0.319057439275057 358 76075 SGTC_1806 st050005 60.3 µM 0.469479350550861 0.338009174066597 no 1126 0.319363520701067 326 5194765 SGTC_2368 9071271 200 µM 0.468281516122533 0.338395069718005 no 1127 0.319791642422987 378 27209959 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.467819991278761 0.338543800401556 no 1128 0.319956661583421 371 279621 SGTC_1471 k673-0312 37 µM 0.467726948882461 0.338573787232462 no 1129 0.31998993340102 335 24099884 SGTC_946 3434-1334 87.4 µM 0.466675886589273 0.338912607369914 no 1130 0.320365892172841 341 4047976 SGTC_2961 9083290 32.55 µM 0.464570456516424 0.339591705089278 no 1131 0.32111954655859 338 17741490 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.464088270663457 0.339747305550434 no 1132 0.321292252468813 345 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2892 9047358 58.44 µM 0.460758574646921 0.340822536397255 no 1133 0.322485912694311 366 6466771 SGTC_809 3998-0021 90 µM 0.460340714613684 0.340957564031825 no 1134 0.322635840667677 356 715485 SGTC_2902 5787006 60.46 µM 0.459604189101416 0.341195615089564 no 1135 0.322900175867991 345 591003 SGTC_1231 0242-0792 125 µM 0.45829988043947 0.341617333348668 no 1136 0.323368505010253 374 3707635 SGTC_765 1319-0117 244 µM 0.457371289283769 0.341917692541171 no 1137 0.323702098541057 337 3487746 YGL099W LSG1 SGTC_1338 1486-1223 76 µM 0.454933064091713 0.342706829224419 no 1138 0.324578697446894 361 3444526 SGTC_207 4185-0010 4.486 µM 0.454693098372375 0.342784531814434 no 1139 0.324665023381733 356 3761753 SGTC_2564 betulinic acid 100 µM 0.454538607414884 0.342834560594308 no 1140 0.32472060537275 352 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_820 1582-0060 59.9 µM 0.454173140798004 0.342952920555697 no 1141 0.324852106677253 345 3848840 SGTC_1141 3253-0389 52.6 µM 0.453015529459019 0.343327926066638 no 1142 0.325268779569346 372 5402031 SGTC_2584 androsterone 48.74 µM 0.449949856907615 0.344321788194686 no 1143 0.326373298428659 326 2754130 A steroid. SGTC_1244 0416-0015 52.5 µM 0.449855867738459 0.344352275631138 no 1144 0.326407185539389 364 96201 SGTC_2316 5844804 197.44 µM 0.448717108504709 0.344721737328145 no 1145 0.326817870666452 365 776813 SGTC_2648 atorvastatin 78.68 µM 0.448537177124745 0.344780128246126 no 1146 0.326882780807295 382 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_3156 9099931 49.47 µM 0.448414595626176 0.34481991023006 no 1147 0.326927005012098 353 18111053 SGTC_2215 7188065 200 µM 0.446669184381506 0.345386543188022 no 1148 0.327556967308617 373 940217 SGTC_2284 7945075 39.21 µM 0.444745469922351 0.346011462400275 no 1149 0.328251852780065 378 1245402 SGTC_2519 cryptotanshinone 88.04 µM 0.444402606893916 0.346122885665655 no 1150 0.328375764510211 342 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_335 4077-0256 27.6 µM 0.444272155690304 0.346165283059538 no 1151 0.32842291492707 362 3121989 SGTC_926 2268-1401 59.4 µM 0.441729712151141 0.346991976292458 no 1152 0.32934240316987 349 2931578 SGTC_2149 5554786 194.827 µM 0.440466543680421 0.347402975576181 no 1153 0.329799619265826 349 745063 YPR165W RHO1 SGTC_830 4076-0286 57.8 µM 0.439422270295573 0.347742888143313 no 1154 0.330177796321261 350 6866659 SGTC_3044 9093193 49.47 µM 0.439207404138403 0.34781284259786 no 1155 0.330255630294635 367 25236277 SGTC_2860 9025725 38.96 µM 0.438216314928058 0.348135580757887 no 1156 0.330614741439647 368 40546248 SGTC_431 k089-0097 107 µM 0.43765535035782 0.348318301961737 no 1157 0.330818070429789 349 5499420 SGTC_572 0960-0087 17.7 µM 0.437430430851829 0.348391574167671 no 1158 0.330899609489164 368 6796365 SGTC_511 blebbistatin 171 µM 0.437223318033227 0.348459050478848 no 1159 0.33097470026529 369 3476986 A myosin inhibitor. SGTC_466 geldanamycin 89.2 µM 0.436638484125629 0.348649612298907 no 1160 0.33118677421588 353 5288382 HSP90 inhibitor. SGTC_2015 5119600 184 µM 0.436538698343056 0.348682130235456 no 1161 0.331222964199373 389 2828786 SGTC_709 3807-1509 243 µM 0.435758828886588 0.348936310387697 no 1162 0.331505859004851 384 1886677 YPL242C IQG1 SGTC_2839 9003951 25.97 µM 0.435184982904086 0.34912338533015 no 1163 0.331714080959913 362 2990634 SGTC_1705 st027868 56.3335 µM 0.432358507803369 0.350045356255834 no 1164 0.332740434861802 387 292948 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.431700073003726 0.350260259049717 no 1165 0.332979707177862 365 2724278 An inhibitor of dopamine biosynthesis. SGTC_3057 9095946 49.47 µM 0.430411221185903 0.350681058819558 no 1166 0.333448267084396 359 24540043 SGTC_2868 9035608 32.47 µM 0.427841866895505 0.35152047877513 no 1167 0.334383126672098 357 6462614 SGTC_766 1391-0721 126 µM 0.426521610507518 0.351952094753656 no 1168 0.334863902216974 383 1020919 YIL115C NUP159 SGTC_1038 k292-0204 154 µM 0.425186657123004 0.352388709494802 no 1169 0.335350305065325 347 4454212 SGTC_2403 6032726 181.2 µM 0.424949740052272 0.352466216807221 no 1170 0.335436656908135 340 2881040 SGTC_373 0844-0104 25.9 µM 0.423938575100582 0.352797087801183 no 1171 0.335805305318762 370 5375804 SGTC_1688 st021091 57.6 µM 0.42386907737232 0.352819832775771 no 1172 0.33583064846441 381 3656366 SGTC_2561 acetosyringone 100 µM 0.41973476248151 0.354173840840098 no 1173 0.337339613608478 381 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2833 9001315 45.46 µM 0.419696148464625 0.354186495842918 no 1174 0.337353719552596 349 2989378 SGTC_913 3487-1245 167 µM 0.419581010153686 0.354224231170111 no 1175 0.337395781661409 340 4016153 SGTC_211 3455-0679 143.504 µM 0.419464909595469 0.354262283312789 no 1176 0.337438197354175 354 748649 SGTC_1066 ketoconazole 628 nM 0.417490470427171 0.35490963140374 no 1177 0.338159846602986 383 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_3325 9138760 55.175 µM 0.41714138580681 0.355024127436727 no 1178 0.338287497545686 334 43844959 SGTC_1356 1502-0781 85.8 µM 0.416462183161947 0.355246936172666 no 1179 0.33853591711197 359 567702 SGTC_175 3793-3120 23.7 µM 0.41580979249454 0.355460995989702 no 1180 0.338774596323115 389 5322297 SGTC_2097 5376186 200 µM 0.415470232488186 0.355572429110464 no 1181 0.338898851065634 353 742755 SGTC_1102 cgs 12066b 26.1 µM 0.412864633935079 0.356427916393119 no 1182 0.339852896790312 355 6438352 A 5-HT1B full agonist. SGTC_2420 aureobasidin a 50 nM 0.410309617415896 0.357267498408258 no 1183 0.340789418991268 340 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_672 1441-0018 53.7 µM 0.408774233084734 0.357772360752289 no 1184 0.341352675479243 362 251141 SGTC_556 4058-0063 51.5 µM 0.406999634595107 0.358356191153508 no 1185 0.342004128285471 379 6615692 SGTC_22 0964-0034 14.468 µM 0.40636164163028 0.358566167375327 no 1186 0.342238449793509 392 138402 SGTC_680 0417-1641 114 µM 0.400223671140116 0.360588472349675 no 1187 0.344495890672922 368 2835990 SGTC_2210 7115885 190.385 µM 0.400142607160307 0.360615207118963 no 1188 0.344525741928778 387 2927039 SGTC_1022 4477-0945 21.3 µM 0.398815792954807 0.361052885044041 no 1189 0.345014469687158 369 4648966 SGTC_395 anisomycin 6.25 µM 0.397949919936932 0.361338609873101 no 1190 0.345333550772829 390 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2422 chlorphenesin carbamate 384.24 µM 0.397501025341756 0.361486768671071 no 1191 0.345499015292553 347 2724 A muscle relaxant with antifungal properties. SGTC_1992 st073643 23.3 µM 0.395150860374877 0.362262785169935 no 1192 0.34636577774359 363 3161292 SGTC_214 4373-3496 70 µM 0.39374901964406 0.362725938128377 no 1193 0.346883173195686 380 3779166 SGTC_2846 9008642 19.48 µM 0.392647213323206 0.363090104029414 no 1194 0.347290031617305 405 2992898 SGTC_980 1473-0395 201 µM 0.389860471541113 0.364011721976237 no 1195 0.348319862401444 387 768876 SGTC_3235 9132602 49.47 µM 0.3898337792117 0.364020553350125 no 1196 0.348329731882877 378 4912240 SGTC_1933 st074711 15.9 µM 0.389542180860958 0.364117035734796 no 1197 0.348437556980415 361 17250958 SGTC_848 0368-0089 85.6 µM 0.388904226662346 0.364328148377225 no 1198 0.348673497701821 413 762535 SGTC_3199 9111318 49.47 µM 0.387788332039565 0.36469752064196 no 1199 0.349086340431589 382 8548020 SGTC_1781 st038725 66.3 µM 0.387713165969181 0.364722405882149 no 1200 0.349114155727509 353 4270275 YIL048W NEO1 SGTC_2254 7938975 95.19 µM 0.38632230141008 0.365182982335478 no 1201 0.349628992988632 372 2969277 SGTC_2603 homopterocarpin 100 µM 0.386094943194003 0.365258289161152 no 1202 0.349713177397231 373 101795 A weak amylase inhibitor. SGTC_2203 7227154 166.4 µM 0.382890450824452 0.366320250037357 no 1203 0.350900495983678 370 896304 SGTC_2931 9014674 55.67 µM 0.382811862081181 0.366346307057354 no 1204 0.350929632796974 374 2996810 SGTC_1222 0366-0074 1.18 µM 0.381820093656473 0.366675192435671 no 1205 0.351297406685338 403 286520 SGTC_1418 3966-3099 2.4 µM 0.381065128212072 0.36692561602069 no 1206 0.351577461175787 395 740335 SGTC_576 1073-0113 22.7 µM 0.37852723734778 0.367767854287791 no 1207 0.352519481936762 403 5439563 SGTC_1884 5633444 25 µM 0.378118070041192 0.367903702439502 no 1208 0.352671442582945 366 5724239 SGTC_2524 avocatin b 10.57 µM 0.377043359254005 0.368260597180716 no 1209 0.353070691349101 371 6710748 SGTC_1723 st034307 2.5525 µM 0.375060023784277 0.368919530417479 no 1210 0.353807913428552 369 867466 SGTC_60 0986-0278 202 µM 0.374933441420659 0.368961598601001 no 1211 0.353854983782904 411 3110598 SGTC_3296 9122258 64.045 µM 0.374644702255915 0.369057563594389 no 1212 0.353962361402431 384 4730474 SGTC_1857 st056007 79.3 µM 0.373967897241097 0.369282537657054 no 1213 0.354214100208272 369 619834 SGTC_1769 st044406 64.4 µM 0.373777277753784 0.369345908807242 no 1214 0.354285012964616 404 670903 SGTC_3192 9110362 49.47 µM 0.373509925311157 0.369434795689705 no 1215 0.354384479821452 398 16649480 SGTC_1777 st045864 34.765 µM 0.372338747449201 0.369824260338119 no 1216 0.354820326435264 414 4691462 SGTC_2227 7312221 64.1025 µM 0.371991433042377 0.369939782310795 no 1217 0.354949613918432 414 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1158 4092-0494 91.8 µM 0.371916770336802 0.36996461777781 no 1218 0.354977409227035 385 1148199 SGTC_2587 piperic acid 92.2 µM 0.371461892140436 0.370115938130817 no 1219 0.355146767200803 381 5370536 SGTC_2034 5197015 53.07 µM 0.371344741452822 0.370154912882899 no 1220 0.355190388794189 405 780676 SGTC_1765 st044815 90.4 µM 0.370834523998088 0.3703246721919 no 1221 0.355380392716627 379 645695 SGTC_2089 5281248 129.67 µM 0.370307523455688 0.370500042081392 no 1222 0.355576684372382 369 2737878 SGTC_887 0885-0007 9.62 µM 0.369481901575518 0.370774838248242 no 1223 0.355884280389601 407 5719458 SGTC_1938 st074717 56.4 µM 0.369445969788896 0.37078679911592 no 1224 0.355897669369753 387 17250979 SGTC_1501 4491-0275 38.4 µM 0.369150399818645 0.370885192317299 no 1225 0.356007812035166 405 5104718 SGTC_2570 licareol 100 µM 0.368225395820852 0.371193174289387 no 1226 0.356352587753014 375 443158 SGTC_1240 0356-0016 42.1 µM 0.366979517687826 0.371608122335659 no 1227 0.356817148122197 386 4305613 SGTC_2859 9028643 45.46 µM 0.366904489719466 0.371633115671093 no 1228 0.356845131178781 381 17151580 SGTC_3285 9112818 20.8695 µM 0.366818987131417 0.371661598974145 no 1229 0.356877021876 400 17017947 YPR165W RHO1 SGTC_2836 9010338 19.48 µM 0.366010849438201 0.371930846922082 no 1230 0.357178489899791 365 2994051 SGTC_308 4092-1169 104 µM 0.365194247382882 0.372202978581165 no 1231 0.357483206061763 405 2268590 YDL196W YDL196W SGTC_1834 st055981 52.8 µM 0.365029789724058 0.372257791626377 no 1232 0.357544584660319 397 471719 YDL150W RPC53 SGTC_3177 9107506 49.47 µM 0.363910828623758 0.372630805310028 no 1233 0.357962299109527 412 8897194 SGTC_1208 2323-2347 50.3 µM 0.363869314931285 0.372644646497086 no 1234 0.357977799679357 411 5412760 SGTC_433 pimozide 108 µM 0.363129242017247 0.372891423695333 no 1235 0.358254170715868 369 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_104 0074-0074 590.992 µM 0.361684169173764 0.373373433317279 no 1236 0.358794029228225 379 3943124 SGTC_2560 caryophyllene 100 µM 0.361635353634394 0.373389719393709 no 1237 0.358812270948018 371 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1258 0671-0043 57.1 µM 0.361013581096847 0.37359717793298 no 1238 0.359044647261402 394 4298767 SGTC_1883 5-benzylidenerhodanine 20 µM 0.360910838643043 0.373631462164032 no 1239 0.359083050431711 384 1273210 SGTC_1968 st069590 43.6 µM 0.360674278925018 0.373710403812127 no 1240 0.359171477357452 386 6384066 SGTC_221 trifluoperazine 10.304 µM 0.358614797055169 0.374397890986394 no 1241 0.359941637851325 411 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_3118 9124250 49.47 µM 0.357754092833699 0.37468532598897 no 1242 0.360263674162859 409 1504786 SGTC_3173 9105693 49.47 µM 0.357284168045335 0.374842288316376 no 1243 0.360439540481208 389 17096658 SGTC_195 4234-0266 16.654 µM 0.355973577361426 0.375280155856614 no 1244 0.360930176499633 392 2303354 SGTC_7 0192-1582 4.227 µM 0.354442618256994 0.375791851888914 no 1245 0.36150360007561 390 252616 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.350301727623848 0.377176963911748 no 1246 0.363056134425942 418 688669 SGTC_122 0236-0016 402.397 µM 0.349703210199904 0.377377296946373 no 1247 0.363280722114725 401 6808838 SGTC_1503 4585-0012 61.3 µM 0.348975806055031 0.377620814780826 no 1248 0.363553736539614 384 2922052 SGTC_58 0957-0393 9 µM 0.348672616142517 0.377722330018785 no 1249 0.363667552377096 375 6997992 SGTC_2023 5144124 124 µM 0.348053375325053 0.377929692897985 no 1250 0.363900049373009 403 2830192 SGTC_337 1315-0038 354 µM 0.348017075397199 0.377941849612439 no 1251 0.363913679914346 415 1626437 SGTC_1076 itraconazole 331 nM 0.346709214336995 0.378379928089792 no 1252 0.364404893546993 377 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_724 3910-0327 137 µM 0.3419721723866 0.379967943103935 no 1253 0.366185917166088 415 2885483 SGTC_2630 antimycin a 100 µM 0.341699805945462 0.380059311297679 no 1254 0.366288409080534 391 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_417 st075190 100 µM 0.34105178640439 0.380276723186332 no 1255 0.366532298173785 429 222757 SGTC_1106 tegaserod maleate 11.7 µM 0.339412545190753 0.380826860727212 no 1256 0.367149484609805 398 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.339183512890242 0.38090374432674 no 1257 0.367235744345958 377 16725076 SGTC_3243 9134147 49.47 µM 0.33723518650549 0.381557965718785 no 1258 0.36796980713119 404 24282180 SGTC_2628 lathosterol 100 µM 0.337189537410575 0.381573298127275 no 1259 0.367987011943986 382 6710616 SGTC_2606 farnesol 9.78 µM 0.33713408281935 0.381591924210849 no 1260 0.368007912733485 388 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2816 7982706 58.44 µM 0.336798370034452 0.381704689246562 no 1261 0.368134450945183 380 2981853 SGTC_699 0375-0592 111 µM 0.335828437552779 0.382030543374216 no 1262 0.368500122135243 385 762578 SGTC_340 k038-0059 454 µM 0.335615151760298 0.382102209123068 no 1263 0.368580548329193 401 23733424 SGTC_2359 9039622 200 µM 0.334924624164142 0.382334259671532 no 1264 0.368840973205731 405 6463596 SGTC_2086 5274770 176.623 µM 0.334752692473882 0.382392043579593 no 1265 0.368905824719326 389 689278 SGTC_1893 st059353 36.1 µM 0.334376383172924 0.382518525166778 no 1266 0.369047779159281 425 3112488 SGTC_1127 asiatic acid 681.4 nM 0.330134239195873 0.383945219225907 no 1267 0.370649266523789 393 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1425 4048-4433 7.33 µM 0.329968354858903 0.384001040623909 no 1268 0.370711936677485 441 23734946 SGTC_771 0250-0039 27.3 µM 0.329859914932323 0.384037532822101 no 1269 0.370752906515825 427 3005115 SGTC_1891 st059073 26.2 µM 0.327810567860746 0.384727371961469 no 1270 0.371527448233537 435 688754 SGTC_483 fpl-64176 144 µM 0.324283903820306 0.385915350536395 no 1271 0.372861552355306 422 3423 SGTC_2005 4024620 188 µM 0.321113233215916 0.386984324986542 no 1272 0.374062291139816 418 236743 SGTC_474 dl-dihydrosphingosine 5 µM 0.320678522439613 0.387130952421581 no 1273 0.374227012497559 373 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2116 5511452 16.8835 µM 0.320197391868001 0.387293255977152 no 1274 0.37440935009647 424 870744 SGTC_3134 9127454 49.47 µM 0.318061461842685 0.388014023563245 no 1275 0.375219157900374 406 24262820 SGTC_2575 plumbagin 510 nM 0.317549545813476 0.388186826575993 no 1276 0.375413325537335 394 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1036 k216-0215 33.5 µM 0.317114974158008 0.388333538501198 no 1277 0.375578181546964 393 622330 SGTC_200 k038-0079 37.545 µM 0.316838543297954 0.388426870192534 no 1278 0.375683058214699 414 3436683 SGTC_541 4513-1321 94 µM 0.313874845985118 0.389427910730854 no 1279 0.376808047819941 390 747515 SGTC_25 0118-0223 35.662 µM 0.313048715751971 0.389707081781231 no 1280 0.377121825504898 422 5333628 SGTC_68 0986-0284 82.829 µM 0.312816150433113 0.389785681968218 no 1281 0.377210172239458 352 423278 YIL048W NEO1 SGTC_1132 3456-3614 2.5 µM 0.312004415112475 0.390060059758699 no 1282 0.377518583969725 388 3125502 SGTC_925 2064-1272 59.6 µM 0.311397766398336 0.390265151211058 no 1283 0.377749125856397 414 6815817 SGTC_2060 5238662 140 µM 0.310181558075954 0.390676410155611 no 1284 0.378211446955625 390 790130 SGTC_1351 1496-0003 46.5 µM 0.3098353711563 0.390793495106619 no 1285 0.378343076000149 415 3891978 SGTC_453 enantio-paf c16 10 µM 0.308920479579143 0.391102971055975 no 1286 0.378691008901248 434 13871343 A lipid and platelet activating factor SGTC_1426 4048-4480 71.7 µM 0.306763213619732 0.391832971684287 no 1287 0.379511805170707 406 14224343 SGTC_1898 st060199 18.6 µM 0.304673725287899 0.392540400207041 no 1288 0.380307331470773 392 688866 SGTC_3300 9124615 50.48 µM 0.303229454792057 0.393029588036471 no 1289 0.380857501695182 399 24824903 SGTC_2364 9055074 200 µM 0.302411326482495 0.393306770714143 no 1290 0.38116926071872 405 6470630 SGTC_261 5-fluorouridine 15.376 µM 0.302300318631264 0.393344384454118 no 1291 0.381211567732183 385 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2181 6316240 54.2555 µM 0.302020933245287 0.393439055399707 no 1292 0.381318052620607 400 12779990 SGTC_3270 9137563 49.47 µM 0.298546522672888 0.394616899117165 no 1293 0.382643037033754 433 17015724 SGTC_2709 st078560 56 µM 0.29837049465866 0.394676599300663 no 1294 0.382710202947239 425 17250903 SGTC_1990 st072050 59.8 µM 0.296905144711382 0.395173670959964 no 1295 0.383269464140079 392 17233948 SGTC_677 0929-0063 136 µM 0.295771526704323 0.395558330601602 no 1296 0.383702284507654 418 1539583 SGTC_829 1635-0120 117 µM 0.295709423302562 0.39557940649222 no 1297 0.383726000059253 401 285054 SGTC_2605 digitonin 300 nM 0.295053681710634 0.395801962652621 no 1298 0.383976435988479 406 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2105 5350118 200 µM 0.293857664143588 0.39620797383952 no 1299 0.384433334807257 407 2133313 SGTC_1930 st074634 34.3 µM 0.293043455904908 0.396484436949174 no 1300 0.384744467965072 393 684253 YOR116C RPO31 SGTC_402 epigallocatechin gallate 10 µM 0.292076942944238 0.396812682445475 no 1301 0.385113897642662 425 65064 An antioxidant. SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.29155364597683 0.396990434206154 no 1302 0.385313960677593 402 66535 A nucleotide analog. SGTC_2739 tacrine 100.86 µM 0.290984154422422 0.397183901507838 no 1303 0.385531719171211 420 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2020 4017018 200 µM 0.29004233907768 0.397503909907598 no 1304 0.385891923586432 423 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_3146 9095609 49.47 µM 0.287583996531852 0.39833952588597 no 1305 0.386832598257532 396 17173999 SGTC_2048 5246248 200 µM 0.28673252971322 0.398629057176037 no 1306 0.387158563916832 420 677046 SGTC_2481 5478948 45.16 µM 0.286616990692775 0.398668349165949 no 1307 0.387202801670039 395 77792 SGTC_2991 9074669 71.4286 µM 0.285616145742227 0.399008754954469 no 1308 0.387586067934817 443 17333109 SGTC_2620 irigenin 100 µM 0.285247822821946 0.399134047710173 no 1309 0.387727142108554 461 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1043 0916-0009 19.3 µM 0.284498465400367 0.399388989398265 no 1310 0.388014204952213 438 3101130 SGTC_3025 9087895 49.47 µM 0.282543205947829 0.400054397318155 no 1311 0.388763510966655 414 17173641 SGTC_460 trequinsin 123 µM 0.282330971876402 0.400126641667319 no 1312 0.388844869513157 418 5537 A vasodilator. SGTC_2872 9044037 25.97 µM 0.280685666517465 0.40068681839003 no 1313 0.389475751721511 421 6465195 SGTC_2344 7990960 76.95 µM 0.279632052439542 0.401045649504961 no 1314 0.389879906711499 424 140813 SGTC_3329 9141233 27.5565 µM 0.279302130365878 0.401158028799189 no 1315 0.390006485762385 434 4909101 YNL103W MET4 SGTC_1852 st056254 31.4 µM 0.279080238347543 0.401233615091065 no 1316 0.390091624187773 436 442583 SGTC_1265 0819-1001 68.8 µM 0.278899961631011 0.401295028081733 no 1317 0.390160798993144 445 3106768 SGTC_223 busulfan 5 mM 0.277124554978016 0.401899967401539 no 1318 0.390842233887474 427 2478 A DNA alkylator. SGTC_739 1486-1183 203 µM 0.276817870000884 0.402004488893659 no 1319 0.390959979447399 443 4346692 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.275839502267464 0.402337973799533 no 1320 0.391335670923197 444 140250 A respiratory chain inhibitor. SGTC_2091 4-phenylthiadiazole 200 µM 0.275184078600277 0.402561420274052 no 1321 0.391587409189905 407 270010 SGTC_3272 9137413 49.47 µM 0.273922737017443 0.402991525292801 no 1322 0.392071999009551 415 17614870 SGTC_1717 st033143 58.0435 µM 0.273870157063433 0.40300945709031 no 1323 0.392092203134308 447 674616 SGTC_1465 k213-0056 144 µM 0.273434105603028 0.403158175356946 no 1324 0.3922597694152 413 24048857 YMR208W ERG12 SGTC_515 4092-1064 102 µM 0.272639233217097 0.403429307928413 no 1325 0.392565275138285 452 717353 SGTC_596 1155-0152 116 µM 0.272270146661868 0.403555219886316 no 1326 0.392707154462392 425 280313 SGTC_2552 juarezic acid 87.02 µM 0.271326600016787 0.403877151330704 no 1327 0.393069924836722 398 1549512 SGTC_1702 st027038 51 µM 0.271275689210397 0.403894523591544 no 1328 0.393089501427776 410 5521182 SGTC_2379 9035213 200 µM 0.271056573890813 0.403969294330597 no 1329 0.39317376031872 451 646551 SGTC_983 1491-0821 12.2 µM 0.270072963259655 0.404304984039454 no 1330 0.393552060836801 399 46495113 SGTC_123 0083-0120 66.675 µM 0.27004966278538 0.404312936953487 no 1331 0.393561023510854 417 16001701 SGTC_348 k064-0012 10.7 µM 0.269546033384286 0.404484845316294 no 1332 0.393754761504859 411 5066323 SGTC_1253 0550-0034 176 µM 0.269376808269581 0.404542612590893 no 1333 0.393819865544832 404 5969915 SGTC_266 formosanin C 406 nM 0.268924948523537 0.404696871200851 no 1334 0.393993718906793 422 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1207 2099-0101 141 µM 0.268734517982217 0.404761885967815 no 1335 0.394066993524419 425 5837381 SGTC_1624 st003710 6.25 µM 0.268100975168906 0.404978202321528 no 1336 0.394310797613113 453 24207033 SGTC_3356 9151811 4.48 µM 0.267851209355823 0.40506349014592 no 1337 0.394406925513701 445 1859254 YPR165W RHO1 SGTC_924 2046-0044 21.3 µM 0.267656495137168 0.405129982566118 no 1338 0.394481870051269 403 3623589 SGTC_905 2-aminofluorene 215 µM 0.267535306320053 0.405171368383062 no 1339 0.394528516998464 407 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1437 4092-1038 11.6 µM 0.267185315803119 0.405290895622707 no 1340 0.394663240798058 443 3977136 SGTC_497 capsazepine 133 µM 0.266852072836063 0.405404711522051 no 1341 0.394791529579233 396 2733484 A calcium channel blocker. SGTC_879 0831-1030 162 µM 0.266765302090453 0.405434348540616 no 1342 0.394824935647274 425 1549252 SGTC_2923 7992654 58.14 µM 0.264627973865714 0.406164535337026 no 1343 0.39564803406123 434 2985126 SGTC_1961 st076550 68.7 µM 0.264133623689034 0.406333469398742 no 1344 0.395838477831096 409 1579337 SGTC_3121 9125696 49.47 µM 0.262156438553266 0.407009306018949 no 1345 0.396600418069311 451 1235365 SGTC_825 1988-2224 89.6 µM 0.260053909193286 0.407728291356111 no 1346 0.397411095064665 414 1180859 SGTC_1462 k081-0014 26.5 µM 0.259498384556924 0.407918311744345 no 1347 0.397625364140635 424 3270634 SGTC_439 amiodarone 34.4 µM 0.258173281756778 0.408371658137409 no 1348 0.398136588587639 436 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_148 3253-0744 288.01 µM 0.257669753091477 0.408543958402827 no 1349 0.398330895774655 408 6893655 SGTC_2534 helenine 20.12 µM 0.257372486325276 0.408645687115655 no 1350 0.398445620187022 424 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1075 aripiprazole 15.2 µM 0.255979377933986 0.409122509581421 no 1351 0.398983380478689 404 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2164 5685496 200 µM 0.255750368418831 0.409200906094817 no 1352 0.399071799896293 391 759046 SGTC_1197 1601-0112 267 µM 0.252556287934645 0.410294708502616 no 1353 0.400305556124671 448 7350313 SGTC_2027 5150920 200 µM 0.251496012819174 0.410657951020133 no 1354 0.400715322232832 451 786715 SGTC_2476 5806916 10.51 µM 0.250268064770894 0.411078732824024 no 1355 0.401190025691282 451 2870194 SGTC_2001 4023502 57.655 µM 0.248863092160775 0.411560301255613 no 1356 0.401733342715384 416 108941 YCR052W RSC6 SGTC_2280 7785178 200 µM 0.248327979931917 0.41174375141311 no 1357 0.401940326009198 417 2954328 SGTC_992 3909-8734 162 µM 0.248218199461601 0.41178138935226 no 1358 0.401982792883765 435 4288319 SGTC_70 0141-0289 43.283 µM 0.247119936192176 0.41215797058447 no 1359 0.402407702637048 414 352408 SGTC_1032 k061-1018 98.7 µM 0.243376426823146 0.413442180626067 no 1360 0.403856901779312 420 4005393 SGTC_1868 st057644 42.7 µM 0.242454791994482 0.413758489907763 no 1361 0.40421389133215 408 688665 SGTC_2953 9074162 66.49 µM 0.241998152655415 0.413915231360937 no 1362 0.404390797331357 466 16451992 SGTC_2905 7799065 20.05 µM 0.241989666452435 0.413918144379993 no 1363 0.404394085144371 451 1296806 SGTC_2926 9010726 65.15 µM 0.241367439375879 0.414131746243035 no 1364 0.404635173211642 412 2994293 SGTC_656 4090-1979 187 µM 0.24055250219042 0.414411541207785 no 1365 0.404950983482371 436 22330961 SGTC_1072 oxiconazole 14.9 nM 0.239870876912742 0.414645599139012 no 1366 0.405215179331608 430 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_975 1335-0046 28.5 µM 0.239788447579476 0.414673905953817 no 1367 0.4052471316165 433 16486740 SGTC_3219 9131112 49.47 µM 0.23950940073903 0.414769735896337 no 1368 0.405355303915278 416 17612988 YMR079W SEC14 SGTC_2079 5212404 121 µM 0.23924237990121 0.414861440632202 no 1369 0.405458821112453 420 758462 SGTC_1680 diphenhydramine 100 µM 0.239132920595325 0.414899034308085 no 1370 0.405501257616856 456 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_343 4130-2827 29.8 µM 0.238674192277113 0.415056592507627 no 1371 0.405679115022861 409 1118244 SGTC_2264 7948757 110.76 µM 0.237888818192708 0.415326374569561 no 1372 0.405983664192147 439 2971411 SGTC_139 0099-0334 718.624 µM 0.237292078589564 0.415531385930255 no 1373 0.406215103503417 427 97690 SGTC_11 0438-0307 1.3 µM 0.235877284871172 0.416017533588621 no 1374 0.406763947504249 441 4011476 SGTC_3317 9138495 8.753 µM 0.235725850837837 0.416069576576973 no 1375 0.406822704509415 459 17020139 SGTC_531 3788-1495 174 µM 0.233972344833397 0.416672306940941 no 1376 0.407503224222501 418 2896655 SGTC_1168 k815-0004 80.5 µM 0.232492178268734 0.417181235266805 no 1377 0.408077880820016 436 642433 SGTC_1619 st003326 88.7 µM 0.232100591989926 0.417315898331174 no 1378 0.408229942545439 428 2849032 SGTC_2705 st078069 42.8 µM 0.230896558934056 0.417730015364119 no 1379 0.408697582043102 435 1530061 SGTC_3059 1327-0034 3 µM 0.230630762672845 0.417821446061777 no 1380 0.4088008333212 415 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_492 tmb-8 126 µM 0.229901180736777 0.418072436236666 no 1381 0.409084279402796 453 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_212 3807-4682 38.772 µM 0.229569057737846 0.418186703975395 no 1382 0.409213326538277 431 3125501 YBL034C STU1 SGTC_1064 honokiol 6.76 µM 0.229339284476654 0.418265762075964 no 1383 0.409302611213059 441 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2842 9000675 19.48 µM 0.229287830638574 0.418283466253951 no 1384 0.409322605651773 465 2989072 SGTC_20 0481-0013 4.944 µM 0.227275272566717 0.418976074478231 no 1385 0.410104849828203 442 182045 SGTC_3258 9138477 49.47 µM 0.226764518291822 0.419151887149242 no 1386 0.410303427644217 446 4970355 SGTC_2134 5324836 1.464 µM 0.226747069995439 0.419157893515717 no 1387 0.410310211830702 466 699272 SGTC_1698 5-fluorocytosine 1.055 µM 0.226348654581402 0.419295048361055 no 1388 0.410465129639178 453 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1851 st056236 18.9 µM 0.225128393054305 0.419715185377683 no 1389 0.41093969670525 440 5393171 SGTC_3305 9127027 53.8275 µM 0.224114727125056 0.42006426098323 no 1390 0.411334016670806 435 41905295 SGTC_2517 totarol 10 µM 0.22251907751323 0.420613881327032 no 1391 0.411954911902711 418 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2296 7971656 126.45 µM 0.222178334747335 0.42073127001788 no 1392 0.4120875295067 439 666570 SGTC_1507 4075-3230 155 µM 0.2219068767944 0.420824794565059 no 1393 0.412193188542097 454 659771 SGTC_591 4299-0174 154 µM 0.221827368093185 0.42085218829196 no 1394 0.412224136760119 459 5509088 SGTC_1215 3852-0577 11.2 µM 0.221782362862678 0.420867694450163 no 1395 0.412241654980152 409 2884876 SGTC_2259 7964009 200 µM 0.22173478317848 0.42088408774735 no 1396 0.412260175492658 413 313134 SGTC_2252 omeprazole 400 µM 0.221027868164222 0.421127667256482 no 1397 0.412535366947221 457 4594 A proton pump inhibitor. SGTC_722 3534-0461 190 µM 0.218069755281853 0.422147261483821 no 1398 0.413687381050565 425 658262 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.21721189838433 0.4224430431846 no 1399 0.414021606235537 446 165506 SGTC_2202 7226349 200 µM 0.216900130398054 0.422550548957714 no 1400 0.414143087990148 421 844334 SGTC_2544 sphondin 68.51 µM 0.215310142739833 0.423098907949788 no 1401 0.414762761154276 463 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_383 2324-0395 7.37 µM 0.21512889209121 0.423161427616489 no 1402 0.414833414298862 450 3146421 SGTC_1727 st034309 9.9045 µM 0.213734795070332 0.423642364837432 no 1403 0.415376937867171 470 870305 SGTC_3308 9128332 17.569 µM 0.213464190580124 0.423735731498314 no 1404 0.415482458594515 455 17332805 YDL196W YDL196W SGTC_2778 tioconazole 65.09 nM 0.21301790360663 0.423889723233416 no 1405 0.415656499049173 454 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_700 3453-2283 142 µM 0.212059169344903 0.424220574655877 no 1406 0.416030436691819 430 565664 SGTC_3247 9135149 49.47 µM 0.211152899544942 0.424533370128948 no 1407 0.416383981393315 467 8934436 YOR116C RPO31 SGTC_3007 9078383 71.4286 µM 0.211050651936117 0.424568663478326 no 1408 0.416423873436919 420 6496995 SGTC_555 4296-0685 37 µM 0.210915936346525 0.424615164896094 no 1409 0.416476434221597 456 2908540 YHR072W ERG7 SGTC_642 0335-0876 158 µM 0.210645237933445 0.424708608329871 no 1410 0.416582054730999 468 6812350 SGTC_2016 5121758 140 µM 0.209977033092691 0.424939286649931 no 1411 0.416842799188201 465 2795203 SGTC_662 k832-1615 104 µM 0.209611275594851 0.425065564697306 no 1412 0.416985539247284 481 5878478 SGTC_1953 st076800 12.1 µM 0.208559376897388 0.425428776313728 no 1413 0.417396112836194 428 297591 SGTC_2406 ethylparaben 405.7 µM 0.20748469632268 0.425799919682214 no 1414 0.417815671598663 403 8434 A possible steroid mimic. SGTC_3006 9075424 71.4286 µM 0.207382177319394 0.425835328292144 no 1415 0.417855700243964 461 7465181 SGTC_1403 3909-7815 62.9 µM 0.205838558340706 0.426368544531079 no 1416 0.418458510435964 464 6615483 SGTC_902 1120-0002 2.07 µM 0.20445533784971 0.426846468309119 no 1417 0.418998844996213 440 3280475 SGTC_2206 7254556 146.969 µM 0.203392894183318 0.427213631776503 no 1418 0.419413976679365 450 4398905 SGTC_1161 k007-0610 110 µM 0.203312443494095 0.427241436814869 no 1419 0.419445415069222 458 5843850 SGTC_300 r073-0011 5.04 µM 0.203216636951153 0.427274549552142 no 1420 0.419482854865502 451 2735780 SGTC_1375 2910-0797 186 µM 0.201652427611622 0.427815245196468 no 1421 0.42009422787315 477 742508 SGTC_1788 fluconazole 20 µM 0.200799305062347 0.428110198764553 no 1422 0.420427753171227 471 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1966 st070145 16.1 µM 0.200581748123961 0.428185422054389 no 1423 0.420512815453698 469 3748532 SGTC_2387 9077560 195.08 µM 0.200382970374627 0.428254154464119 no 1424 0.420590538532683 428 5303272 SGTC_1697 st025554 27.742 µM 0.200184693958383 0.428322715693671 no 1425 0.420668068672163 443 1269519 SGTC_472 calcifediol 10 µM 0.200120404310244 0.428344946625244 no 1426 0.420693207902065 447 5283731 A vitamin D metabolite. SGTC_2154 5570129 200 µM 0.198289355785024 0.428978206196493 no 1427 0.421409339600837 482 673366 SGTC_2515 chrysin 20.77 µM 0.198120945017001 0.429036459480407 no 1428 0.421475218939564 432 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1169 aniline yellow 25.8 µM 0.197983046848487 0.429084159607328 no 1429 0.421529163921435 468 6051 A DNA damaging agent. SGTC_3039 9090270 49.47 µM 0.197400190577159 0.429285785885735 no 1430 0.421757190247665 466 17173750 SGTC_731 3966-0296 387 µM 0.197179926451419 0.429361986210997 no 1431 0.421843369303729 446 660956 SGTC_2255 7941087 197.44 µM 0.196742899019277 0.429513183543436 no 1432 0.422014368785684 463 935561 SGTC_1488 4013-0813 75.9 µM 0.196591291564624 0.429565637227739 no 1433 0.422073692975046 453 2910057 SGTC_331 k048-0133 24.5 µM 0.196095795368181 0.429737079425849 no 1434 0.422267593591401 431 6813582 SGTC_2256 7954252 200 µM 0.194324958149234 0.430349899021298 no 1435 0.422960722165303 453 2972920 SGTC_2740 felodipine 17.08 µM 0.19312743858477 0.430764410316496 no 1436 0.42342958213708 469 3333 L-type calcium channel blocker SGTC_594 1487-1584 10.8 µM 0.192369644455053 0.43102675380314 no 1437 0.423726334262475 452 5013332 SGTC_1376 2910-0861 41.3 µM 0.191167448563181 0.431443008738594 no 1438 0.424197202777858 441 1112859 SGTC_1420 4'-methoxyflavone 42 µM 0.1903430153583 0.431728509081434 no 1439 0.424520174181628 465 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1198 1612-1005 86.7 µM 0.188834020382212 0.432251164715326 no 1440 0.425111453544974 459 6998509 SGTC_1663 st014140 55.4 µM 0.187087429767863 0.432856262002067 no 1441 0.42579604187079 452 4207120 SGTC_3132 9126706 49.47 µM 0.185754090487176 0.433318296572175 no 1442 0.426318804165503 487 850858 SGTC_1415 3966-0071 78.1 µM 0.185597366945311 0.433372611099631 no 1443 0.426380259282352 468 2893185 SGTC_1421 4029-0249 71.4 µM 0.185168194186782 0.433521352790526 no 1444 0.426548557516712 463 2894095 SGTC_1074 carmofur 3.8 µM 0.184707103860968 0.433681166889105 no 1445 0.426729386989803 464 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_676 falcarinol 140 µM 0.184371731129099 0.433797414030283 no 1446 0.426860922467777 470 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_917 harmaline 728.087 nM 0.183392175740874 0.434136980987063 no 1447 0.427245157306564 438 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1871 st057448 67.3 µM 0.183363234808045 0.434147014222479 no 1448 0.427256510564315 480 691747 SGTC_1612 st002233 45.4 µM 0.177681247368853 0.436117657980414 no 1449 0.429486656663065 475 1035021 SGTC_485 niflumic acid 177 µM 0.177143335192684 0.436304301270194 no 1450 0.429697901790397 460 4488 A COX2 inhibitor. SGTC_314 1671-0008 2.74 µM 0.176808710344036 0.436420415640019 no 1451 0.429829323492826 465 3913060 SGTC_1063 disulfiram 1.84 µM 0.176649759921634 0.436475573141608 no 1452 0.429891752947829 444 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_717 1532-0246 73.2 µM 0.176197802087589 0.436632414103836 no 1453 0.430069273727612 444 9561992 SGTC_1154 4088-0362 150 µM 0.175921322178544 0.4367283646374 no 1454 0.430177876956136 471 6618304 SGTC_1784 st039334 36.3 µM 0.175499661721645 0.436874706291006 no 1455 0.430343518280949 488 3496984 SGTC_1483 3453-0561 55.9 µM 0.174370450357086 0.437266653347652 no 1456 0.430787167870874 468 4546991 SGTC_159 3970-0959 50 µM 0.17285786888086 0.437791763837149 no 1457 0.431381574409167 448 6615653 SGTC_1562 morin hydrate 59.1 µM 0.172500622989567 0.437915801989435 no 1458 0.431521985813602 451 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_3226 9131256 49.47 µM 0.172286335619619 0.437990206919012 no 1459 0.431606213162184 448 17178073 SGTC_1130 3454-2858 15.9 µM 0.170758885675148 0.438520631935841 no 1460 0.432206679324285 494 715628 YIL048W NEO1 SGTC_2381 9035592 200 µM 0.167580333185797 0.439624774784172 no 1461 0.433456722111664 459 4749657 SGTC_558 k064-0027 21.3 µM 0.167129651110031 0.439781367730916 no 1462 0.433634017955434 447 5088526 SGTC_24 0417-1663 219 µM 0.166645642318053 0.439949550792817 no 1463 0.433824439217338 469 4329390 SGTC_338 4055-0136 114 µM 0.165173118544078 0.44046128891203 no 1464 0.434403861462699 442 2900563 SGTC_3099 9120367 49.47 µM 0.163790803227714 0.440941767904093 no 1465 0.434947915932068 487 24824940 SGTC_1474 0330-0125 5.35 µM 0.162963114312341 0.441229505964697 no 1466 0.435273738447332 481 X1474 SGTC_1917 st066507 28.5 µM 0.162222982994451 0.441486831751663 no 1467 0.435565130850091 456 3156428 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.161722780929974 0.441660753925242 no 1468 0.435762082052617 502 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1770 st043884 66.3 µM 0.158263978272944 0.442863698897028 no 1469 0.437124395769458 495 670149 SGTC_1284 0929-0043 16 µM 0.158156482969758 0.442901093436265 no 1470 0.437166746826612 474 1239883 SGTC_129 0088-0017 176.636 µM 0.157293028593061 0.443201482923402 no 1471 0.43750695712398 481 182446 SGTC_966 1300-0360 30.2 µM 0.156989243562998 0.443307175294453 no 1472 0.437626662689618 478 70588 SGTC_205 1486-1330 71.903 µM 0.155056732939133 0.443979625240181 no 1473 0.438388295837445 479 4118834 SGTC_271 rotenone 740 µM 0.154667157937602 0.444115204089136 no 1474 0.438541861271213 480 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1616 st002734 56.1 µM 0.153882071916579 0.444388447478721 no 1475 0.438851360130365 462 4026101 SGTC_2713 st079149 53.4 µM 0.152653001132022 0.444816269519354 no 1476 0.439335962956185 474 3103253 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.151994275398933 0.445045589062036 no 1477 0.439595725381658 476 616764 SGTC_1009 4106-0057 9.87 µM 0.15192469610288 0.44506981249806 no 1478 0.439623164856836 490 2928005 SGTC_578 3460-0051 92 µM 0.151617928950886 0.445176613299229 no 1479 0.439744145818859 491 2876744 SGTC_767 0929-0023 86 µM 0.151363005244377 0.445265367863485 no 1480 0.439844685359925 469 1204563 SGTC_2361 9034121 116 µM 0.151269675536619 0.445297862340435 no 1481 0.439881494699925 463 6496917 SGTC_2528 xanthyletin 44.79 µM 0.149781765338807 0.445815955493046 no 1482 0.440468398101289 476 65188 An natural product with antifungal activity of unknown mechanism. SGTC_3169 9102970 49.47 µM 0.149622940586696 0.445871264054375 no 1483 0.440531053977732 473 17027839 SGTC_1209 2323-2347 50.3 µM 0.148936918796874 0.446110173906148 no 1484 0.440801704550559 472 5412760 SGTC_2888 9058547 12.99 µM 0.146793732612704 0.4468566727815 no 1485 0.441647415872348 456 16476514 SGTC_667 1498-1044 59 µM 0.14622963473478 0.447053186630561 no 1486 0.441870055934407 501 6739982 SGTC_1380 2291-0730 164 µM 0.145631637864209 0.447261524010799 no 1487 0.442106095418777 447 2999191 SGTC_2675 theaflavin digallate 100 µM 0.145325624359395 0.447368142328433 no 1488 0.442226892084233 487 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_512 prima-1 270 µM 0.144601207391182 0.447620551950339 no 1489 0.442512871947153 460 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2339 9000433 200 µM 0.144295279447858 0.447727153230167 no 1490 0.44263365287734 463 2988954 SGTC_2754 granisetron 64.02 µM 0.143868384063418 0.447875912195462 no 1491 0.442802200890562 488 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2440 5628896 157.78 µM 0.143513349623799 0.44799963557581 no 1492 0.442942384453387 489 5522048 SGTC_499 genistein 192 µM 0.142264240460222 0.448434968710782 no 1493 0.443435645581934 504 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1239 0337-0584 35.4 µM 0.142143880833697 0.44847691912052 no 1494 0.443483179076797 486 914301 YML130C ERO1 SGTC_2253 7938677 135.83 µM 0.140955081098546 0.448891296876361 no 1495 0.443952714024785 466 2301972 SGTC_3126 9127922 49.47 µM 0.140850889606505 0.448927617378784 no 1496 0.443993869835135 499 45595682 SGTC_416 estradiol valerate 100 µM 0.140723682852844 0.448971961437678 no 1497 0.444044117530397 467 13791 A steroid. SGTC_2634 4'-methoxyflavone 100 µM 0.139983151132244 0.449230122180247 no 1498 0.444336651376482 466 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1309 pyrazolanthrone 13.4 µM 0.139544102391996 0.449383191477225 no 1499 0.444510104079262 494 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1572 epiandrosterone 68.9 µM 0.138935755609027 0.449595297035974 no 1500 0.444750458036541 469 441302 A steroid. SGTC_2783 7738165 71.43 µM 0.138553794545336 0.449728478548458 no 1501 0.444901378819113 496 17201110 SGTC_860 0443-0016 25.1 µM 0.13807502027487 0.449895424715613 no 1502 0.445090563796825 452 5337942 SGTC_190 3970-0790 3.722 µM 0.137624496720769 0.450052528099838 no 1503 0.445268597084208 489 2832352 SGTC_3161 9100388 49.47 µM 0.135667302612982 0.450735117527716 no 1504 0.446042148707838 484 25236368 SGTC_1743 st037606 46.3785 µM 0.135367429232148 0.450839714049472 no 1505 0.446160687386148 458 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_379 3970-0972 5.9 µM 0.132831295387225 0.451724459157819 no 1506 0.447163401760689 466 2898042 YBL034C STU1 SGTC_3072 9116419 49.47 µM 0.132788128126947 0.451739520396985 no 1507 0.447180471795924 457 17170162 SGTC_1986 st071812 45 µM 0.131924615739887 0.452040818074754 no 1508 0.447521959124912 501 11838594 SGTC_893 0958-0369 48.9 µM 0.131489027392624 0.452192814525507 no 1509 0.447694233042694 492 6819948 SGTC_1366 1683-0113 21.9 µM 0.131015234226091 0.452358150318656 no 1510 0.447881628057136 472 708623 SGTC_1283 0922-0125 16.4 µM 0.12980029967813 0.452782153950181 no 1511 0.448362212906233 483 3360884 SGTC_1105 epirubicin 18.1 µM 0.129457960902342 0.452901637525182 no 1512 0.448497643654332 491 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_170 4197-0004 226 µM 0.128945245285477 0.453080594244775 no 1513 0.448700487462963 475 218692 SGTC_3333 9141820 12.094 µM 0.128861291661805 0.45310989807444 no 1514 0.448733703007903 493 1939433 SGTC_2108 5365811 200 µM 0.128565491881792 0.45321314837775 no 1515 0.44885073656438 478 780283 SGTC_773 4358-1457 44.6 µM 0.125253042926003 0.454369588678958 no 1516 0.450161612828523 491 1186886 SGTC_1833 st055984 71 µM 0.125172494897324 0.454397714419244 no 1517 0.450193495925176 459 676288 SGTC_1510 1123-0200 71.5 µM 0.120480226419061 0.456036549568026 no 1518 0.452051371285431 488 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_502 l-744,832 89.3 µM 0.120080370791314 0.456176239281855 no 1519 0.452209740852912 511 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2199 6590217 200 µM 0.11948321480242 0.456384866031176 no 1520 0.452446268707741 479 703109 SGTC_1054 3429-0080 167 µM 0.118461353966109 0.456741898609205 no 1521 0.452851057250931 498 1162877 SGTC_1684 st024538 14.6195 µM 0.117854061159997 0.456954099952069 no 1522 0.453091646684809 484 6732859 SGTC_1657 st012939 43.4 µM 0.117634733428022 0.45703074086228 no 1523 0.45317854135498 503 24207257 SGTC_1615 st002656 86.5 µM 0.117442745581928 0.457097829555894 no 1524 0.453254606173805 470 1584458 SGTC_2216 7189485 200 µM 0.117136373657285 0.45720489142805 no 1525 0.453375993059408 492 731273 SGTC_1123 mangostin 811.285 nM 0.115580203466113 0.457748743926194 no 1526 0.453992626543094 501 5281650 An antioxidant. SGTC_3096 9117468 49.47 µM 0.114619394579444 0.458084568308617 no 1527 0.454373403187068 520 41316311 SGTC_850 0388-0143 75.9 µM 0.113187915788283 0.458584957872499 no 1528 0.454940787951124 492 67273 SGTC_2939 9044578 71.43 µM 0.111089957593242 0.459318441200704 no 1529 0.455772506064858 484 2653634 SGTC_516 3992-2719 87.3 µM 0.111027150839108 0.459340401701533 no 1530 0.455797408288017 456 5350887 YDR037W KRS1 SGTC_1237 0330-0133 46.1 µM 0.1109892204046 0.459353664210065 no 1531 0.455812447393926 491 X1237 YHR072W ERG7 SGTC_682 0kpi-0099 17 µM 0.110315579883422 0.459589212486326 no 1532 0.456079550857818 502 1714895 YML126C ERG13 SGTC_969 1313-0238 134 µM 0.109888272727141 0.459738634051241 no 1533 0.456248991611916 496 5212874 SGTC_2492 derrusnin 100 µM 0.108833963652598 0.460107331100331 no 1534 0.45666709235668 501 1715307 Part of coumarin class of compounds. SGTC_1860 st056228 74.6 µM 0.108270729067798 0.460304311072732 no 1535 0.456890470458249 508 688679 SGTC_1439 4092-1168 46 µM 0.106590016999033 0.460892164050923 no 1536 0.457557119371891 509 2886240 SGTC_657 3534-0529 86.7 µM 0.105872873529279 0.461143021281762 no 1537 0.457841608433056 492 1049549 SGTC_2730 imipramine 71.33 µM 0.102479019363065 0.46233040164172 no 1538 0.459188232643541 507 3696 A tricyclic antidepressant. SGTC_2141 5621638 7.665 µM 0.102445036767183 0.462342292573714 no 1539 0.459201718759934 501 2856238 SGTC_448 monastrol 171 µM 0.102156398400147 0.46244329207596 no 1540 0.459316267833854 498 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_761 k216-0224 480 µM 0.101559141659047 0.462652290108814 no 1541 0.459553305965798 509 1340404 SGTC_1750 st081859 2.357 µM 0.0998111240584658 0.463264032890821 no 1542 0.460247138216725 501 5291695 SGTC_2683 piperine 63.03 µM 0.0992770843681228 0.46345094481259 no 1543 0.460459136272419 521 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_710 3448-4187 58 µM 0.098416128751391 0.463752293073873 no 1544 0.460800933980419 479 3946412 SGTC_3139 9095020 49.47 µM 0.097380566576198 0.46411478396581 no 1545 0.461212088499214 514 25236292 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.0961639936837407 0.464540674356401 no 1546 0.461695163560926 493 77254 SGTC_1500 4488-1866 171 µM 0.095158341785585 0.464892757511672 no 1547 0.462094529110025 514 2900003 SGTC_635 k038-0028 24.7 µM 0.0942471325927419 0.465211799604939 no 1548 0.462456422486783 508 4035102 SGTC_2592 piperlongumine 83.33 µM 0.093134673608334 0.46560133567793 no 1549 0.462898285791294 498 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_495 decylubiquinone 155 µM 0.0926312743822422 0.465777615645039 no 1550 0.463098248597091 509 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1352 1496-0991 99 µM 0.0910586839734441 0.466328347284173 no 1551 0.463722980807837 519 3000039 SGTC_1228 0124-0032 52.5 µM 0.0907689142925278 0.466429833623818 no 1552 0.463838105429423 497 X1228 SGTC_244 nsc-207895 1.295 µM 0.0901910969089031 0.466632209722366 no 1553 0.464067679565593 494 42640 SGTC_2736 butenafine 14.65 µM 0.0894514398417253 0.466891281509662 no 1554 0.464361572099654 515 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_530 4358-1714 28 µM 0.0891806812252057 0.466986120753831 no 1555 0.464469159171936 511 1564641 SGTC_2797 7859098 81.82 µM 0.0888987112167692 0.467084889030351 no 1556 0.464581203899181 506 972681 SGTC_652 0437-0092 114 µM 0.0885041189652718 0.467223109956338 no 1557 0.464738005363539 494 3091274 SGTC_1997 st073024 93.8 µM 0.0875207488339205 0.467567589864134 no 1558 0.465128796763714 512 686268 SGTC_67 0335-0847 266 µM 0.086730268239973 0.4678445171404 no 1559 0.465442958243672 498 4552207 YOR254C SEC63 SGTC_1367 1812-0510 76.9 µM 0.0833930717288058 0.469013799590684 no 1560 0.466769498641888 503 1142582 YDR527W RBA50 SGTC_1478 0453-0656 35.7 µM 0.0821163377947961 0.469461211165086 no 1561 0.467277100659533 506 5258496 SGTC_2719 novobiocin 32.65 µM 0.0812211550872175 0.469774937071551 no 1562 0.467633037884714 496 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1661 st013063 9.66 µM 0.0803271903387386 0.470088254858219 no 1563 0.467988516659917 507 721395 SGTC_1033 k072-0102 21.3 µM 0.0789652176211342 0.470565636149762 no 1564 0.468530144479847 510 5965931 SGTC_3221 9128209 49.47 µM 0.0777914513768901 0.470977083675194 no 1565 0.468996973327909 515 16460723 SGTC_2037 5169046 200 µM 0.0775425562709887 0.47106433440894 no 1566 0.469095969078784 496 5718022 SGTC_2651 TUB2.036 5 µM 0.077447546550854 0.471097640644471 no 1567 0.469133758829791 491 15992207 YFL037W TUB2 SGTC_2629 bisabolol 100 µM 0.0773513739606701 0.471131354737056 no 1568 0.469172011391084 524 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1172 0370-0043 85 µM 0.0770124637763156 0.471250164137578 no 1569 0.469306814878221 507 376585 SGTC_2433 5607874 27.82 µM 0.0769451903043729 0.471273748038294 no 1570 0.469333573710017 522 2252428 SGTC_3303 9125618 40.5795 µM 0.0766304684972793 0.471384080648762 no 1571 0.469458759928157 502 22695467 SGTC_2656 pseudo-anisatin 100 µM 0.0752784931713621 0.47185807003563 no 1572 0.469996566442049 524 6708809 A neurotoxin. SGTC_2942 9052777 62.25 µM 0.0747545546042504 0.472041768550168 no 1573 0.470205000381758 525 6469503 SGTC_3187 9109394 49.47 µM 0.0738345876863459 0.472364333243554 no 1574 0.470571002565786 513 17098090 SGTC_1954 st077032 68.9 µM 0.0735897731109963 0.472450174760317 no 1575 0.470668404474804 520 698907 SGTC_482 fipronil 114 µM 0.0729243032474485 0.472683520845597 no 1576 0.470933177117199 508 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_3018 9082602 49.47 µM 0.0729140733389216 0.472687108022215 no 1577 0.470937247424502 507 17332089 SGTC_1944 st076371 56.9 µM 0.0712688792679994 0.47326403346645 no 1578 0.4715918814872 526 24208455 SGTC_2555 cholic acid 100 µM 0.0705152555959053 0.473528327882782 no 1579 0.471891779282843 497 6708657 Influences liver metabolism. SGTC_2815 7968870 71.43 µM 0.0696088530960118 0.473846216974541 no 1580 0.472252495142034 509 2977326 YHR190W ERG9 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.0690845229478359 0.474030115119532 no 1581 0.472461170245491 512 2333 A French combination drug. SGTC_2426 5582046 32.21 µM 0.0688279399050541 0.47412010842708 no 1582 0.472563288995194 506 2251934 SGTC_1449 4112-4002 201 µM 0.0679401929192876 0.47443148478934 no 1583 0.472916621664918 512 2059539 SGTC_489 paxilline 115 µM 0.0660998398524611 0.475077036313493 no 1584 0.473649169176746 504 105008 A toxic potassium channel blocker. SGTC_3299 9121982 43.1275 µM 0.0634984743494602 0.475989643889641 no 1585 0.474684787043448 506 17594604 YPL160W CDC60 SGTC_3062 9077494 49.47 µM 0.0618446327760645 0.476569908185742 no 1586 0.475343279837757 495 16459633 SGTC_2793 7325131 81.82 µM 0.0616988326800421 0.476621065783037 no 1587 0.475401334793258 502 4176441 SGTC_1937 st074714 47.2 µM 0.0607366820628414 0.476958669927701 no 1588 0.475784458766452 492 17250970 SGTC_1764 st044502 93.5 µM 0.0601708608005319 0.477157215815635 no 1589 0.47600977668171 501 8407 SGTC_1323 1348-1351 11.2 µM 0.0590634009179062 0.477545838301401 no 1590 0.476450804781883 530 6989654 SGTC_163 TUB2.036 7.546 µM 0.0570775613406671 0.478242749202155 no 1591 0.477241705366867 529 15992207 YJR013W GPI14 SGTC_1497 4476-2978 41.3 µM 0.0568671586649914 0.478316591890507 no 1592 0.477325507774513 521 1528379 SGTC_284 0988-0104 32.6 µM 0.0547435364471545 0.479061937216784 no 1593 0.478171392137989 518 4666532 SGTC_32 0928-0142 34.1 µM 0.0546646119119124 0.479089639443793 no 1594 0.478202831395289 522 2244242 SGTC_1305 1181-0477 144 µM 0.0546170948929931 0.479106317794654 no 1595 0.478221759665733 520 6252086 SGTC_1303 1160-0052 261 µM 0.0545875296337241 0.479116695142728 no 1596 0.478233536928155 532 3562476 SGTC_1196 1588-0294 184 µM 0.053899069850047 0.479358347165972 no 1597 0.478507788871256 519 6144269 SGTC_2061 5245884 80.95 µM 0.0522950087969169 0.479921408025694 no 1598 0.479146815140108 518 573863 SGTC_315 k915-0449 187 µM 0.0501516962341573 0.480673820415844 no 1599 0.48000075194979 518 20970215 YNL149C PGA2 SGTC_2135 5326629 150.42 µM 0.0499060078599406 0.480760074057411 no 1600 0.480098644845753 518 5020077 SGTC_3076 9116187 49.47 µM 0.0495531615716 0.480883949125882 no 1601 0.480239236196976 526 27241210 SGTC_2317 5986382 200 µM 0.0495331877189367 0.48089096147649 no 1602 0.480247194837963 535 877883 SGTC_2795 7780010 54.55 µM 0.0461984406041699 0.482061794099703 no 1603 0.481576042683515 525 953673 SGTC_2318 6029776 164 µM 0.046063974045169 0.482109008739134 no 1604 0.481629630029512 530 818325 SGTC_1546 5-methoxyflavanone 78.7 µM 0.0444864605099724 0.482662932550664 no 1605 0.482258322120399 524 147795 SGTC_2277 7947813 106.88 µM 0.0441282036987432 0.482788734574536 no 1606 0.482401105688027 533 1246798 SGTC_837 0091-0265 12.5 µM 0.0438255306085352 0.482895019688277 no 1607 0.482521738074576 526 759367 SGTC_1630 st005209 31.3 µM 0.0426321077812629 0.483314107636923 no 1608 0.482997400220616 530 3367314 SGTC_2817 7995342 71.43 µM 0.0415094864887691 0.483708349423199 no 1609 0.483444865124625 518 18879975 SGTC_1251 0490-5699 265 µM 0.0413929856536993 0.483749263068026 no 1610 0.483491302321957 525 3883818 SGTC_630 4356-0227 183 µM 0.0411676661117518 0.48382839297488 no 1611 0.483581115257487 533 779312 SGTC_2974 9094440 9.66 µM 0.0409767956145537 0.483895425229784 no 1612 0.483657197369186 528 25236134 SGTC_2436 5633522 8.09 µM 0.0409249799613332 0.483913622568474 no 1613 0.483677851498546 519 5724242 SGTC_1490 4089-0339 670 nM 0.0384636125931176 0.484778077570908 no 1614 0.484659021473346 527 742542 SGTC_297 0986-0032 24 µM 0.0379058075606255 0.484973993951303 no 1615 0.484881391307415 519 2847425 SGTC_744 1594-0068 283 µM 0.0354584959597518 0.485833598944482 no 1616 0.485857070486809 526 668392 SGTC_1925 st057770 10.1 µM 0.0354190157511367 0.485847466705004 no 1617 0.485872810923909 504 5989122 SGTC_2886 9058944 51.95 µM 0.0349562144714313 0.486010030879638 no 1618 0.486057327653416 538 4949929 SGTC_269 exalamide 29 µM 0.0342527373078941 0.486257139619682 no 1619 0.486337806448748 535 3316 A derivative of salicylamide. SGTC_2380 9035439 200 µM 0.0331685637043027 0.48663798498712 no 1620 0.486770083426063 524 6462575 SGTC_3207 9114163 49.47 µM 0.0329795810992713 0.48670437150703 no 1621 0.486845435352566 524 849233 SGTC_535 2293-4129 48.2 µM 0.032723915663553 0.486794183208421 no 1622 0.486947376080267 534 396118 YIL048W NEO1 SGTC_336 4111-0029 111 µM 0.0324413334800012 0.486893451166954 no 1623 0.487060050235736 528 3131175 SGTC_961 1252-1571 372 µM 0.0317664132972973 0.487130546348243 no 1624 0.487329165708568 529 6813498 SGTC_978 1416-0512 87.4 µM 0.0290954303196454 0.488068889546313 no 1625 0.488394240166636 535 6814003 SGTC_608 k048-0125 159 µM 0.0283967767716457 0.488314344677103 no 1626 0.488672847464874 534 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1505 k297-0037 20.6 µM 0.0278948291202612 0.488490694657008 no 1627 0.488873016302257 533 4089396 SGTC_1269 0831-0796 3.05 µM 0.0276246916208472 0.488585603381196 no 1628 0.488980744056235 534 927758 SGTC_2946 9065502 71.43 µM 0.0274536064361104 0.48864571190759 no 1629 0.489048971293058 531 16489101 SGTC_568 1193-0097 7.48 µM 0.0259411278341861 0.489177112407198 no 1630 0.489652147902902 528 3646150 SGTC_352 k048-0007 5.11 µM 0.0250938301211702 0.489474813953664 no 1631 0.48999006074212 538 6811911 SGTC_2635 hydroquinidine 100 µM 0.0231690519542172 0.49015111423137 no 1632 0.490757712470353 539 442912 An experimental heart treatment. SGTC_354 2783-3500 4.88 µM 0.0230831618238055 0.490181293718096 no 1633 0.490791968513254 539 6740761 SGTC_856 0433-0016 11.3 µM 0.0229327856332555 0.490234132010951 no 1634 0.49085194405694 524 3911780 SGTC_1087 pterostilbene 9.05 µM 0.0223271683825439 0.490446931929659 no 1635 0.491093488523004 536 5281727 Similar to reservatol, lowers cholesterol. SGTC_1293 1000-1278 195 µM 0.0221253370295335 0.490517851414088 no 1636 0.491173987697088 536 678847 SGTC_2674 ligustilide 100 µM 0.0215380751860344 0.490724205129895 no 1637 0.491408215446898 537 5319022 A signalling regulator. SGTC_79 0052-0007 94.094 µM 0.0206363822629466 0.491041049334711 no 1638 0.491767858895241 539 2801472 SGTC_636 0kpi-0074 126 µM 0.0199326945323561 0.491288320799424 no 1639 0.492048531928229 540 616434 SGTC_299 1273-0059 1.44 µM 0.0179486401229467 0.491985522819101 no 1640 0.492839913022709 535 2848077 SGTC_147 4466-0538 29.23 µM 0.0179140571184011 0.491997675602582 no 1641 0.492853707427546 531 6742687 YHR072W ERG7 SGTC_3032 9089427 49.47 µM 0.0167586360828448 0.492403705301173 no 1642 0.493314584441415 539 17173707 SGTC_701 4424-0219 185 µM 0.0165837735906303 0.492465154908793 no 1643 0.493384334789229 537 2911779 SGTC_1104 tacrolimus 29.8 µM 0.0164170020426314 0.492523761389756 no 1644 0.493450857954309 540 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1178 0988-0033 191 µM 0.0143159707184227 0.493262114480036 no 1645 0.494288949073241 541 5392207 SGTC_1107 amlodipine 47 µM 0.0132929773792764 0.493621627529981 no 1646 0.494697025466917 539 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1651 st011928 86.1 µM 0.012476113532148 0.493908703722857 no 1647 0.49502287993489 543 720198 SGTC_3245 9134821 49.47 µM 0.0120410789048104 0.494061592290997 no 1648 0.495196420600062 540 17014901 SGTC_1739 st037196 92.5 µM 0.0119273948157333 0.494101545571596 no 1649 0.495241770733025 538 612214 SGTC_292 k038-0015 474 µM 0.0117048931106167 0.494179742024187 no 1650 0.495330529873927 538 46368540 SGTC_452 diindolylmethane 8 µM 0.0116062829621262 0.49421439784739 no 1651 0.495369866959304 543 3071 Inhibits expression of several cancer promoting factors. SGTC_1626 st003712 1.76 µM 0.0114573812091343 0.494266728373781 no 1652 0.495429266214462 541 24207035 SGTC_1046 2001-0062 216 µM 0.00977472751119992 0.494858092417599 no 1653 0.4961005100128 544 739778 SGTC_109 0132-0036 33.701 µM 0.00887028439753767 0.495175961230256 no 1654 0.496461314919802 547 67274 A color developer. SGTC_2764 methyldopa 94.69 µM 0.0079580609413831 0.495496567565851 no 1655 0.496825226530629 539 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_168 3970-0862 530.542 µM 0.0077014267189798 0.495586763716236 no 1656 0.496927605634045 541 3135186 SGTC_2246 7293507 91.5585 µM 0.00646310672184839 0.496021984273108 no 1657 0.497421611416554 544 887656 SGTC_3171 9103192 49.47 µM 0.00532932103455735 0.496420469314774 no 1658 0.497873918577528 545 13018434 SGTC_1156 4092-0367 4.88 µM 0.00473827603036312 0.496628201895967 no 1659 0.498109708428516 544 1357585 SGTC_2600 tangeritin 87.95 µM 0.00327244349724946 0.49714339690581 no 1660 0.498694486258823 546 68077 A bioactive flavone. SGTC_1492 4158-0558 28.5 µM 0.00191826632970694 0.497619352745037 no 1661 0.499234722925347 547 3967268 SGTC_1675 st018485 24.5 µM 0.00182541867696796 0.497651986260113 no 1662 0.499271763714756 547 3323024 SGTC_1578 josamycin 24.2 µM 0.000363971580358483 0.498165648517797 no 1663 0.499854796350936 547 5282165 A P450 substrate. SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -4.64398983683709e-05 0.498309898515063 no 1664 0.49998147316105 548 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2806 7952793 58.44 µM -0.000222555606463442 0.498371799119669 no 1665 0.499911213159574 549 2972490 SGTC_520 3584-0023 682 µM -0.000238015612864406 0.498377232956816 no 1666 0.499905045509529 548 1340790 SGTC_2281 7943571 200 µM -0.000238536471959544 0.49837741602683 no 1667 0.49990483771682 549 1244024 SGTC_1232 0279-0259 161 µM -0.00111714593148082 0.498686227535395 no 1668 0.499554323347256 550 1560000 SGTC_616 4092-0450 108 µM -0.00277333050521747 0.499268341239513 no 1669 0.498893602622226 550 787165 SGTC_797 k781-0471 270 µM -0.00334934688628672 0.499470799192461 no 1670 0.498663806413594 553 23738129 SGTC_3140 9094243 49.47 µM -0.00407384922211712 0.499725447102565 no 1671 0.498374773796761 550 19291112 SGTC_2118 5526350 200 µM -0.00418999633779655 0.499766270476492 no 1672 0.498328438197136 553 743594 SGTC_543 3844-1095 191 µM -0.00485498316827287 0.5 no 1673 0.498063149552414 550 4230703 SGTC_3288 9119690 36.221 µM -0.00598752610376829 0.499601933933497 no 1674 0.497611336954656 554 17595618 YKL019W RAM2 SGTC_1714 st033236 13.627 µM -0.00687533647090515 0.499289886700375 no 1675 0.497257159198916 554 2916566 SGTC_2031 5180455 200 µM -0.00767768569230232 0.499007877685083 no 1676 0.496937076653355 549 29949 SGTC_1728 st035614 33.7865 µM -0.00992794033818016 0.498216963211817 no 1677 0.496039389904166 565 15945546 SGTC_2404 5161160 200 µM -0.010297854525746 0.498086947187835 no 1678 0.495891823041542 554 2831543 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.0104060892070165 0.498048905313793 no 1679 0.49584864596456 555 1377 SGTC_2995 9067767 71.4286 µM -0.0107471817092196 0.497929019662386 no 1680 0.495712577355448 558 11673567 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.0109394119158078 0.497861455539697 no 1681 0.495635893106876 556 803109 SGTC_2276 7947513 42.08 µM -0.0113342215338279 0.497722690001461 no 1682 0.495478396625905 573 2105100 SGTC_2844 9010103 25.97 µM -0.0122569664421815 0.497398369741111 no 1683 0.495110300289619 553 2480525 SGTC_1824 st053723 68.6 µM -0.0125357951991259 0.497300369187404 no 1684 0.494999072256391 556 675225 SGTC_1965 Pectolinarigenin 58.4 µM -0.0129547120725543 0.49715313186478 no 1685 0.494831962178185 556 5320438 An anti-inflammatory. SGTC_2707 st078556 66.6 µM -0.0134925576993865 0.496964095051607 no 1686 0.494617411579363 554 17250899 SGTC_1763 st044482 94.5 µM -0.0135083140890524 0.496958557157229 no 1687 0.494611126262151 556 88505 SGTC_1307 1187-1599 12.2 µM -0.0140148134018644 0.496780538287184 no 1688 0.494409081406033 555 1538471 SGTC_1744 st037937 38.9 µM -0.0151236300132181 0.496390825770492 no 1689 0.493966774546218 556 1016152 SGTC_455 paf C-16 10 µM -0.0153891972287037 0.496297488138753 no 1690 0.493860840885163 562 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1726 st035556 14.5795 µM -0.0171342482256631 0.495684168736921 no 1691 0.493164758392703 565 5919439 SGTC_1556 plumbagin 1.48 µM -0.0174389442233028 0.495577080627036 no 1692 0.493043220437778 555 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1747 st037496 66.6 µM -0.0189158592305606 0.495058010409838 no 1693 0.492454113984065 555 723305 SGTC_2691 st077356 60.2 µM -0.0192096295126594 0.494954764135504 no 1694 0.492336937890372 560 2839272 SGTC_1985 st071382 65.5 µM -0.0193181198410776 0.494916635032941 no 1695 0.492293664541419 578 6123237 SGTC_3276 9139060 49.47 µM -0.0197029314745677 0.494781392734689 no 1696 0.492140176128053 569 4870619 SGTC_465 cgp-37157 41 µM -0.0214901465388507 0.494153282950103 no 1697 0.491427331786122 571 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2115 tiliquinol 12.7705 µM -0.0237634088360607 0.493354374903416 no 1698 0.490520663660132 560 71208 A bioactive hydroxyquinoline. SGTC_394 menadione 8.33 µM -0.0241739128676402 0.493210111424636 no 1699 0.490356943281972 554 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_650 1328-0195 38 µM -0.0255634996164726 0.49272177549684 no 1700 0.489802749817832 558 2780821 SGTC_117 lucigenin 22.078 µM -0.0257300275628309 0.49266325408231 no 1701 0.489736336624684 569 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_385 1494-0393 12.4 µM -0.0267796361739308 0.492294403278392 no 1702 0.489317747685983 573 3090647 SGTC_1941 st076221 61.8 µM -0.0268946460973767 0.492253987176755 no 1703 0.489271881884866 568 2828568 SGTC_74 000s-0487 160.283 µM -0.0270715176709993 0.492191832178143 no 1704 0.489201346018827 558 677548 SGTC_12 0849-0099 9.267 µM -0.0271414495379541 0.492167257251999 no 1705 0.489173457487948 557 6071388 SGTC_1448 4255-0083 152 µM -0.0277421638546946 0.491956160018413 no 1706 0.488933897369845 566 5399660 SGTC_782 0083-0095 30.5 µM -0.0278798312510329 0.491907782584428 no 1707 0.488878997260251 590 3591729 An indicator and reagent. SGTC_268 camptothecin 39.6153 µM -0.0286162483749305 0.491649001703392 no 1708 0.488585326531063 561 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1452 4194-0072 190 µM -0.0299311841131692 0.491186935126689 no 1709 0.488060967829686 586 1343545 SGTC_673 1082-0474 110 µM -0.031514981135387 0.490630406828 no 1710 0.487429422430588 561 3098046 SGTC_2495 cafestol 54.53 µM -0.0315315370754513 0.490624589353002 no 1711 0.487422820846969 584 16667697 An anti-infammatory. SGTC_584 0986-0246 15.4 µM -0.0317427235060285 0.490550382218217 no 1712 0.487338611804221 568 53315 YDR232W HEM1 SGTC_1960 st011366 51.8 µM -0.0344974164187277 0.489582463296353 no 1713 0.486240251261423 560 3972846 SGTC_237 nikkomycin 200 µM -0.0353989434233596 0.489265705989681 no 1714 0.485880813605688 576 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2475 5812728 15.03 µM -0.0377234873318729 0.488448994267868 no 1715 0.484954074569927 569 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1652 st011932 78 µM -0.0380668275976053 0.488328368166857 no 1716 0.484817199936253 570 1551076 SGTC_1245 0418-0076 17.2 µM -0.0384128974708112 0.488206784150415 no 1717 0.484679238938722 571 6790114 SGTC_2972 9093619 59.92 µM -0.0391075959202689 0.487962720493418 no 1718 0.484402302467507 568 25236256 SGTC_2003 4023581 200 µM -0.040848006812579 0.487351293827317 no 1719 0.483708533685524 573 16641307 SGTC_1570 verbenone 133 µM -0.040926695757204 0.487323650174022 no 1720 0.483677167568035 562 29025 A natural terpanoid with antifungal properties. SGTC_711 k292-0785 179 µM -0.0411990317257001 0.487227978233491 no 1721 0.483568612794945 562 4146315 SGTC_995 3931-2021 34.6 µM -0.043326949907454 0.486480463855762 no 1722 0.482720454234842 574 730143 SGTC_1923 st058458 19.1 µM -0.0433490060240057 0.486472716027498 no 1723 0.482711663376694 572 3534982 SGTC_197 4544-0043 41.561 µM -0.043356337811675 0.486470140533002 no 1724 0.482708741163975 571 896523 SGTC_2858 9025781 8.96 µM -0.0443791380729195 0.486110859050998 no 1725 0.482301095334293 582 4894980 YPL153C RAD53 SGTC_2234 tolnaftate 200 µM -0.0446378971660826 0.486019965903841 no 1726 0.482197967590935 568 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_951 1171-0579 82.7 µM -0.0447415148840715 0.485983568775735 no 1727 0.482156671360638 569 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1632 st005650 90 µM -0.0468266416135733 0.485251164972335 no 1728 0.481325697691142 577 2759605 SGTC_3152 9099253 49.47 µM -0.047340442682703 0.48507069914269 no 1729 0.481120947799943 580 25236131 SGTC_1056 3448-1962 115 µM -0.0473519575977143 0.485066654715991 no 1730 0.481116359159465 577 715507 SGTC_586 0957-0265 8.15 µM -0.0475423132660098 0.484999795605048 no 1731 0.48104050366736 568 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1807 st050092 58.9 µM -0.0486954663790656 0.484594779754187 no 1732 0.480580994448429 585 5008496 SGTC_1438 4092-1045 4 µM -0.0490667194191397 0.484464389880201 no 1733 0.480433062751607 563 1351342 SGTC_1550 gossypolone 36.6 µM -0.0491377116818491 0.484439456476013 no 1734 0.480404775058204 567 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2567 aureobasidin a 60 nM -0.0492395269957741 0.484403697722361 no 1735 0.480364205733555 566 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2871 9038510 12.99 µM -0.0495365270874565 0.484299388462432 no 1736 0.480245864256098 567 4945164 SGTC_1907 st060210 83.7 µM -0.0506901814130447 0.483894224336962 no 1737 0.479786200344729 577 688793 SGTC_2111 5486399 200 µM -0.0511402291335899 0.483736171780112 no 1738 0.479606889851517 570 689674 SGTC_1278 0874-0585 172 µM -0.0516906122995454 0.483542885827929 no 1739 0.479387608770352 571 766306 SGTC_40 0327-0103 19.753 µM -0.0525561223061758 0.483238940102586 no 1740 0.47904278897468 579 409036 SGTC_1318 1280-3875 124 µM -0.0531141339418496 0.48304298535918 no 1741 0.47882048504613 577 373245 SGTC_3242 9133940 49.47 µM -0.0543481889624691 0.482609641742143 no 1742 0.478328878508957 600 17248444 SGTC_1958 st076513 41.9 µM -0.0551392388410977 0.48233187201928 no 1743 0.478013767802183 583 732122 YGL099W LSG1 SGTC_2934 9036370 36.88 µM -0.0554153757715662 0.4822349111465 no 1744 0.47790377328279 583 6462800 SGTC_1353 1498-1206 8.11 µM -0.057461706168344 0.481516409520235 no 1745 0.477088704866451 572 6756808 SGTC_681 1642-0006 26.6 µM -0.0578842683433312 0.481368048110032 no 1746 0.476920407076694 567 4446530 SGTC_1900 st060200 72.8 µM -0.0583543860857441 0.481202992992543 no 1747 0.476733173725058 573 688945 SGTC_637 1181-0519 7.26 µM -0.0600407724013214 0.480610941025905 no 1748 0.476061580783165 576 6252091 YGR060W ERG25 SGTC_3283 9109332 35.8195 µM -0.0601598646510304 0.480569132041039 no 1749 0.476014155577972 567 17027281 SGTC_2623 humulene 100 µM -0.0618449329110849 0.479977588597428 no 1750 0.475343160329971 588 6187145 An anti-inflammatory. SGTC_1431 4049-0260 9.09 µM -0.0620091715417664 0.479919934940928 no 1751 0.475277764112422 567 3854841 SGTC_3060 1327-0027 12.5 µM -0.0626492844829838 0.479695236334989 no 1752 0.475022891562779 565 16000455 YPR107C YTH1 SGTC_2507 purpurin 79.67 µM -0.0634855690987997 0.479401685392029 no 1753 0.474689925126716 566 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1720 st037298 9.481 µM -0.0636838387564254 0.479332090808214 no 1754 0.474610986713475 583 597396 SGTC_689 0833-0039 98 µM -0.0648888133538206 0.478909146598839 no 1755 0.47413126373679 589 5374726 SGTC_3165 9101544 49.47 µM -0.0651510221145031 0.47881711486137 no 1756 0.474026878458592 584 5002184 SGTC_72 0744-0168 198.391 µM -0.0657408013974725 0.478610114424528 no 1757 0.473792093919434 610 677577 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.0657412215681795 0.478609966955274 no 1758 0.473791926657408 572 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2802 7925815 54.55 µM -0.0664360828125017 0.478366092316725 no 1759 0.47351532185843 580 1262923 SGTC_698 k064-0052 127 µM -0.0668591474997556 0.478217613759389 no 1760 0.473346917901393 572 5088751 SGTC_2825 7998094 58.44 µM -0.0683837516032836 0.477682564741411 no 1761 0.472740077946067 592 2987815 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.0695085104038767 0.477287864331736 no 1762 0.472292429358427 576 5357218 A potent inhibitor of glutathione S-transferases. SGTC_154 3389-1638 511.116 µM -0.0704556218591983 0.476955521199173 no 1763 0.471915510677347 640 5238686 SGTC_738 1315-0003 72.4 µM -0.0704987055051349 0.476940403448821 no 1764 0.471898365422811 596 6251474 SGTC_2704 st078022 71.1 µM -0.0731096226857395 0.47602431360233 no 1765 0.470859442178269 589 54697681 SGTC_2518 prenyletin 46.28 µM -0.0739133512207215 0.475742335473864 no 1766 0.470539666085823 567 3873459 A coumarin with calcium channel inhibitory activity. SGTC_273 hydroxyurea 18.1 mM -0.0742160954054604 0.475636124596148 no 1767 0.470419219444352 583 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1250 0485-0349 40.2 µM -0.0743331406899626 0.475595062396872 no 1768 0.470372653753892 596 6842794 YDL195W SEC31 SGTC_1005 4092-0690 4.4 µM -0.0764102319849 0.474866414133781 no 1769 0.469546364729645 599 1529343 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.0764220566379643 0.474862266257407 no 1770 0.469541661128822 583 279621 SGTC_607 4491-0986 66.8 µM -0.0769290840918139 0.47468441268259 no 1771 0.469339980170144 586 698981 YDR232W HEM1 SGTC_2043 5101342 149 µM -0.0771481822426148 0.47460755964705 no 1772 0.469252831649596 578 678451 SGTC_802 4112-3352 742 µM -0.0790645502881668 0.473935396016544 no 1773 0.468490639992051 575 704594 SGTC_1093 fluphenazine 7.97 µM -0.079679349605467 0.473719771573613 no 1774 0.468246141925982 602 6602611 An atypical antipsychotic. SGTC_2914 7968218 45.32 µM -0.0799445507742303 0.473626761718812 no 1775 0.468140678401293 591 2977111 SGTC_3029 9088683 49.47 µM -0.0816400316149931 0.473032166453847 no 1776 0.467466483451509 588 25236615 SGTC_2762 leflunomide 42.06 µM -0.0822147089747734 0.472830644015471 no 1777 0.467237988486296 583 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2047 4141938 200 µM -0.083512364436144 0.472375620092078 no 1778 0.466722073169021 585 3807862 SGTC_209 4077-0173 175.592 µM -0.0839395908722656 0.472225820660234 no 1779 0.466552230826874 578 15993494 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.0852354288142911 0.471771482005823 no 1780 0.466037112467503 579 4620898 SGTC_807 1315-0151 48 µM -0.0860117882345031 0.471499297243696 no 1781 0.465728523149786 620 4011080 SGTC_719 2810-4230 27.3 µM -0.0862831211642405 0.471404173445377 no 1782 0.465620677896288 579 721079 SGTC_2970 9090938 41.86 µM -0.0868143053019824 0.471217955834391 no 1783 0.465409558284835 597 17217104 SGTC_3093 9117344 49.47 µM -0.0871469220320388 0.471101353345791 no 1784 0.465277364420418 585 24824913 SGTC_183 3914-0051 30.55 µM -0.087220019397912 0.471075728584093 no 1785 0.465248313408414 582 1596232 SGTC_2692 st077426 47.7 µM -0.0882591533126398 0.470711466367213 no 1786 0.46483535157505 589 25238571 SGTC_1377 2944-0135 198 µM -0.0886898796582473 0.47056048497339 no 1787 0.464664187851079 592 1894137 SGTC_749 1000-0129 128 µM -0.089747630563804 0.470189732280338 no 1788 0.464243882458125 604 708470 SGTC_3334 9142812 21.919 µM -0.0901609374058788 0.47004487093728 no 1789 0.464079662645832 598 45283678 SGTC_867 0518-0118 155 µM -0.0901855263152461 0.470036252810235 no 1790 0.464069892891082 590 6848158 SGTC_3227 9130768 49.47 µM -0.0908522879689537 0.469802565961346 no 1791 0.463804981008154 586 17720899 SGTC_503 tyrphostin 8 294 µM -0.0912639766317658 0.469658282368567 no 1792 0.463641420490737 611 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2521 angolensin 13.4 µM -0.0926914346279168 0.469158035374875 no 1793 0.463074350946161 573 821428 A flavenoid. SGTC_103 0844-0104 51.839 µM -0.0931457044472731 0.468998848492414 no 1794 0.462893904170022 586 5375804 SGTC_2398 5228213 48.84 µM -0.0944582516159765 0.468538928874739 no 1795 0.462372572249736 585 80771 YMR134W ERG29 SGTC_2582 agaric acid 100 µM -0.0944902525980723 0.468527716177077 no 1796 0.462359862551186 591 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2157 5649910 96.377 µM -0.0950019781688533 0.468348418073998 no 1797 0.462156627838844 610 2858091 SGTC_470 aa-861 153 µM -0.0954987144575337 0.468174378047092 no 1798 0.461959355654538 589 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2439 5492030 7.2 µM -0.0981090670481965 0.467259897255761 no 1799 0.460922843900111 598 5722370 SGTC_133 0724-0033 378.92 µM -0.098939315959443 0.466969073423757 no 1800 0.460593226206359 590 280309 SGTC_884 0851-0618 334 µM -0.10127128201646 0.466152315250098 no 1801 0.459667556299434 621 9642473 SGTC_1609 st001574 46.4 µM -0.101877411133511 0.46594004508954 no 1802 0.4594269899806 601 3960012 SGTC_2983 9022671 12.99 µM -0.102069815533268 0.465872665903525 no 1803 0.459350629784871 619 6405161 SGTC_882 0843-0131 351 µM -0.102552902853838 0.465703495135666 no 1804 0.459158911874413 616 5425421 SGTC_748 act1.228 77.9 µM -0.104305333270657 0.465089869503713 no 1805 0.458463522832145 600 4421505 YNR035C ARC35 SGTC_1090 efavirenz 20.7 µM -0.104859769783722 0.464895746939596 no 1806 0.458243540990427 596 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2245 6637752 200 µM -0.104997057010359 0.464847680419214 no 1807 0.458189071989148 599 681890 SGTC_3336 9143619 71.43 µM -0.105461780913769 0.464684976733577 no 1808 0.458004697618118 600 45595730 SGTC_2307 7538926 6.34 µM -0.105701415995821 0.464601080813279 no 1809 0.45790962842242 600 96582 SGTC_1683 st010134 710 nM -0.10620640321717 0.46442429062243 no 1810 0.457709295325552 643 3818134 SGTC_1837 st055472 66.5 µM -0.108882646039266 0.46348748700453 no 1811 0.456647785627525 608 676091 SGTC_1682 st012968 530 nM -0.109142459483048 0.463396551479236 no 1812 0.456544749111982 599 24207270 SGTC_1387 3342-1166 1.8 µM -0.109548958754092 0.463254279290214 no 1813 0.456383545964746 598 3418228 SGTC_3148 9097893 49.47 µM -0.112253937822759 0.462307674181507 no 1814 0.455311031590479 594 17174100 SGTC_328 k915-0120 63.5 µM -0.112270856463559 0.462301754183745 no 1815 0.455304324427452 600 6624543 SGTC_126 0417-1624 672.48 µM -0.113317269086614 0.461935620462799 no 1816 0.454889513335948 608 41912 YDL195W SEC31 SGTC_2857 9024691 58.44 µM -0.113905676824741 0.461729754148319 no 1817 0.454656282702075 637 16478292 SGTC_1678 st019265 80.2 µM -0.114225815884283 0.461617751344985 no 1818 0.454529393862049 630 5367020 SGTC_1773 st048542 73.5835 µM -0.11465033625487 0.4614692347339 no 1819 0.454361140085453 602 3237138 SGTC_2343 7990716 14.84 µM -0.116202748070606 0.460926176097215 no 1820 0.453745929431977 579 6456862 SGTC_2710 st078562 53.7235 µM -0.117686108238024 0.460407340894934 no 1821 0.453158187151416 623 17250908 SGTC_1138 3761-0006 1.03 µM -0.117978212233349 0.46030517953347 no 1822 0.453042460710096 602 12061087 SGTC_2272 7805186 180 µM -0.118075981493757 0.460270985992664 no 1823 0.453003727147084 594 2956062 YPR165W RHO1 SGTC_625 k213-0058 121 µM -0.118591669637851 0.460090635567394 no 1824 0.452799432720767 598 3655420 SGTC_3341 9147222 25.867 µM -0.119256205089488 0.459858241229272 no 1825 0.452536189545756 629 1939759 SGTC_3206 9114350 49.47 µM -0.119593147437805 0.459740414534821 no 1826 0.452402724157803 617 17087243 SGTC_2791 5663188 71.43 µM -0.123382629471176 0.458415501578524 no 1827 0.450902055820823 612 54690634 SGTC_3339 9145883 14.936 µM -0.12405520948706 0.45818039591584 no 1828 0.450635780889918 609 2030670 SGTC_2236 dapsone 200 µM -0.125499358870131 0.457675631617815 no 1829 0.450064116286978 597 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2355 9061122 103.12 µM -0.126070211007892 0.457476124099662 no 1830 0.449838173735409 622 5302957 SGTC_993 3909-8757 62.7 µM -0.126224789805141 0.457422102087833 no 1831 0.449776994438238 594 4288324 YLR208W SEC13 SGTC_105 0111-0055 734.78 µM -0.128634202476931 0.456580165769337 no 1832 0.448823550733423 638 5179370 SGTC_2025 5147754 141 µM -0.129047931406307 0.456435613351959 no 1833 0.448659861052 604 315777 YLR208W SEC13 SGTC_3115 9123671 49.47 µM -0.132055941302551 0.455384821719887 no 1834 0.447470022189573 589 3286988 SGTC_1919 st067113 52.3 µM -0.132360054861971 0.455278602619522 no 1835 0.447349754119568 610 1268243 SGTC_2391 6285546 200 µM -0.133043032268464 0.455040067715603 no 1836 0.447079674074821 588 846083 SGTC_334 1502-1024 68.5 µM -0.133720093415295 0.454803615108403 no 1837 0.446811957807276 607 3296216 SGTC_3316 9136639 10.545 µM -0.135369975806361 0.454227487705219 no 1838 0.446159680715867 607 4903665 SGTC_2987 9018338 71.43 µM -0.135891138860124 0.454045521162962 no 1839 0.445953670329348 614 5055682 SGTC_805 3852-0218 479 µM -0.136658167135637 0.453777727172332 no 1840 0.445650498506171 600 6615355 SGTC_2663 amphotericin b 100 µM -0.136971079538966 0.45366848551832 no 1841 0.445526827404976 619 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2659 sanguinarine 24.21 µM -0.138883612567306 0.453000872685383 no 1842 0.444771060368286 611 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_518 1021-0119 62.6 µM -0.139235194780497 0.452878159373463 no 1843 0.444632148973928 630 1097762 SGTC_601 0986-0029 62.9 µM -0.139683946145825 0.452721537493449 no 1844 0.444454855579666 612 24747981 SGTC_2771 fluoxetine 41.05 µM -0.139899603387874 0.452646272053221 no 1845 0.444369657329157 604 3386 A selective serotonin reuptake inhibitor. SGTC_1903 st060211 78.3 µM -0.140302081394902 0.45250580979816 no 1846 0.444210659938424 601 688960 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.140524987637897 0.452428019498656 no 1847 0.444122605544836 611 165521 SGTC_1737 st035557 69.7 µM -0.141084903553606 0.452232626900346 no 1848 0.443901434787771 604 5716916 SGTC_1461 k072-0203 53.8 µM -0.141845253923723 0.451967307671337 no 1849 0.443601118984276 612 5418714 SGTC_1192 1488-0095 21.4 µM -0.14429437039577 0.45111285110023 no 1850 0.442634011780773 627 915875 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.144901185684003 0.450901178053581 no 1851 0.442394445138239 650 688798 SGTC_922 1866-0035 480 µM -0.145630896184177 0.450646654437773 no 1852 0.442106388185218 644 3156169 SGTC_2776 terbinafine 19.92 µM -0.146051419267067 0.450499984855425 no 1853 0.441940398440148 581 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2448 5185112 27.17 µM -0.147047210294974 0.450152700937685 no 1854 0.441547378440695 604 5718189 SGTC_1128 3448-9350 235 µM -0.147161352432655 0.450112896094416 no 1855 0.441502332353526 606 619386 SGTC_3254 9136651 49.47 µM -0.147246363778211 0.450083250372534 no 1856 0.441468783197638 611 16454030 SGTC_3119 9125183 49.47 µM -0.147283536528917 0.450070287331171 no 1857 0.441454113353479 603 22695334 SGTC_1089 terbinafine 2.25 µM -0.147840801866179 0.449875961761302 no 1858 0.44123420395152 622 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1203 3992-3522 103 µM -0.14997195928666 0.449132911106925 no 1859 0.440393369134855 671 5322312 SGTC_959 1222-0044 107 µM -0.150940870246614 0.448795148837983 no 1860 0.440011180008496 630 6083612 SGTC_1792 st045773 43.6 µM -0.151099508292157 0.448739851159022 no 1861 0.439948610186756 624 2919270 SGTC_1160 4092-0570 10.5 µM -0.151621211491254 0.448558004105787 no 1862 0.439742851240766 606 4994975 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.152414334896286 0.448281570404847 no 1863 0.439430075776364 613 364106 SGTC_275 trichlorophene 5.69 µM -0.153076043669399 0.448050958914942 no 1864 0.439169153794669 616 62616 SGTC_2968 9090663 33.37 µM -0.153259157600985 0.447987145152291 no 1865 0.439096953809204 669 25236811 SGTC_3080 9117754 49.47 µM -0.155074208499767 0.447354687270306 no 1866 0.438381407414376 600 9550191 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.155075848566591 0.447354115846235 no 1867 0.438380760942561 665 61125 An anti-inflammatory. SGTC_180 1486-1293 102.781 µM -0.156028535377546 0.447022203868243 no 1868 0.438005264347868 642 4140536 SGTC_1146 3579-1023 7 µM -0.157228264267443 0.446604276305004 no 1869 0.437532476829835 614 X1146 SGTC_2201 6605497 169.863 µM -0.157323074258637 0.446571251608394 no 1870 0.437495118031648 630 670741 SGTC_2875 9039966 71.43 µM -0.158082041706338 0.446306897595877 no 1871 0.437196075657453 640 6463691 SGTC_2749 bexarotene 57.39 µM -0.158642544601505 0.446111685576252 no 1872 0.436975253744281 618 82146 An retinoic acid receptor inhibitor. SGTC_1463 k081-0032 34.1 µM -0.159051064687838 0.445969414374709 no 1873 0.43681432102413 628 977755 SGTC_1617 st002906 78 µM -0.160174871694732 0.445578073300123 no 1874 0.436371661644583 642 5150859 SGTC_2661 dactinomycin 12.96 µM -0.162210558805705 0.44486932529542 no 1875 0.435570022597604 611 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1001 4048-4355 44.4 µM -0.163802365877204 0.444315241905524 no 1876 0.434943364568662 653 21824233 SGTC_2959 9079155 11 µM -0.164086256927043 0.444216435229861 no 1877 0.434831620279093 621 16189457 SGTC_3198 9112019 49.47 µM -0.164246769910175 0.444160571126978 no 1878 0.434768441973596 648 45595555 SGTC_2465 5809242 33.21 µM -0.164291655081667 0.444144949724043 no 1879 0.43475077535748 615 2731748 SGTC_191 3914-0123 66.505 µM -0.164710482476417 0.443999189255748 no 1880 0.434585932927433 647 3144412 SGTC_2441 5730946 39.09 µM -0.165310691716645 0.443790317419689 no 1881 0.434349721913255 612 1774275 SGTC_1862 st057513 3.81 µM -0.165377768680089 0.443766975714785 no 1882 0.434323325377566 616 5393163 SGTC_623 k072-0108 16.9 µM -0.165598936814131 0.443690014142287 no 1883 0.434236292019853 639 5382803 SGTC_2997 9067075 71.4286 µM -0.166852615111368 0.443253802309412 no 1884 0.433743009019871 640 27209819 SGTC_1642 st009582 77.7 µM -0.167288482127126 0.443102160386272 no 1885 0.433571533183294 648 6739311 SGTC_844 0330-0132 15.3 µM -0.168511143846687 0.442676830291856 no 1886 0.433090588754296 631 2828079 SGTC_2944 9067346 25.62 µM -0.169380981211337 0.442374278188105 no 1887 0.432748491075384 645 6473075 SGTC_3168 9103419 49.47 µM -0.169740035899567 0.442249399399859 no 1888 0.432607293410067 622 16649256 SGTC_588 3970-1144 52.9 µM -0.169944947192895 0.442178134069968 no 1889 0.432526716236814 628 1888707 SGTC_883 0850-0245 24.6 µM -0.170228992328891 0.442079350173149 no 1890 0.432415025940452 613 6823229 YPR165W RHO1 SGTC_1634 st006576 41 µM -0.170378648258857 0.442027304977968 no 1891 0.432356181425271 613 3915356 SGTC_1905 st060207 84.5 µM -0.171083710473893 0.441782122020161 no 1892 0.432078972094905 609 1948547 SGTC_1832 st054113 55 µM -0.171164747788893 0.441753943000226 no 1893 0.432047112791397 623 1251267 SGTC_651 3253-0966 34.4 µM -0.173647163508462 0.440890878702994 no 1894 0.431071381964354 624 781462 SGTC_3030 9087619 49.47 µM -0.174021572836315 0.440760731644327 no 1895 0.430924254115956 618 25236973 SGTC_1887 st057648 70.8 µM -0.174172816615167 0.440708160160445 no 1896 0.430864824094301 636 688672 SGTC_245 methotrexate 289.6 µM -0.174277813886158 0.440671664316155 no 1897 0.430823567185065 610 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_3091 9116372 49.47 µM -0.174380107852272 0.440636108594196 no 1898 0.430783373219983 628 17169793 SGTC_2106 5357045 167.29 µM -0.17460685526531 0.440557296581116 no 1899 0.430694280808953 630 668842 SGTC_1821 st053465 65.6 µM -0.175387463458779 0.440285993746382 no 1900 0.430387595309621 641 675086 SGTC_3005 9076496 71.4286 µM -0.175942303529613 0.440093174369186 no 1901 0.430169635150387 631 21368410 SGTC_1407 3909-7909 12.3 µM -0.17660049435973 0.439864456710163 no 1902 0.429911102872846 614 4411780 SGTC_1048 3161-0300 24.5 µM -0.177067759698407 0.43970209677522 no 1903 0.429727582886845 610 2165101 SGTC_1428 4049-0204 61.7 µM -0.177219840692644 0.439649255623088 no 1904 0.429667855853448 632 X1428 SGTC_2442 5158906 48.48 µM -0.177699759775109 0.439482512864942 no 1905 0.429479386958705 608 1893835 SGTC_1113 artemisinin 1.17947 µM -0.179517018425732 0.438851223299367 no 1906 0.4287658778066 642 2240 An anti-malaria and mitochondrial poison. SGTC_1613 st002381 52.1 µM -0.181962151030944 0.438002065016864 no 1907 0.427806214536349 612 551167 SGTC_2295 7971645 200 µM -0.182655852166337 0.437761204704422 no 1908 0.427534028881381 644 2978226 YKL099C UTP11 SGTC_2052 5265182 7.135 µM -0.182984133319977 0.437647230076185 no 1909 0.427405234098852 630 1239884 SGTC_476 mead acid 10 µM -0.18310611119412 0.437604882380843 no 1910 0.42735738040188 625 5312531 An omega 9 fatty acid. SGTC_1219 1469-0211 33.1 µM -0.18444220370266 0.437141071062242 no 1911 0.426833281967226 650 6822282 SGTC_1020 4335-0961 93.3 µM -0.186814304544558 0.43631783288875 no 1912 0.425903115479934 671 669075 SGTC_2053 5265679 138 µM -0.187094671574624 0.436220549597899 no 1913 0.425793202931014 609 764595 SGTC_3215 9129942 49.47 µM -0.187279848842919 0.436156297888322 no 1914 0.425720610874349 641 17682944 SGTC_19 0279-0214 38.434 µM -0.188057369161558 0.435886536909641 no 1915 0.425415839633223 613 3566274 YBR002C RER2 SGTC_718 1130-0073 349 µM -0.188305987951745 0.435800284810354 no 1916 0.425318395808773 657 6740020 SGTC_2543 pimpinellin 60.67 µM -0.188724603481224 0.435655063476033 no 1917 0.42515433365223 629 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_3249 9135183 49.47 µM -0.190104601565887 0.43517639179749 no 1918 0.424613582154426 662 4902779 SGTC_1136 pergolide 1.05886 µM -0.190323821047128 0.435100361171944 no 1919 0.424527694150539 621 47811 A dopamine receptor agonist. SGTC_1059 3448-6867 171 µM -0.190464027958181 0.435051735277302 no 1920 0.424472764361303 628 3934407 SGTC_2174 5790901 200 µM -0.192356451814398 0.434395510221778 no 1921 0.423731500883201 634 786020 SGTC_836 0330-0104 1.35 µM -0.192560053757354 0.434324919070116 no 1922 0.423651765917724 621 46494820 SGTC_2526 patulin 37.61 µM -0.193258810070878 0.43408266810263 no 1923 0.423378141485006 637 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_131 0141-0277 33.849 µM -0.195695871722042 0.433237960493945 no 1924 0.42242410791272 660 1547771 SGTC_2453 5731132 22.18 µM -0.19682324667467 0.432847305054092 no 1925 0.421982929363485 668 1362040 SGTC_1272 0839-0021 27 µM -0.197742429763319 0.432528840336794 no 1926 0.421623295487678 657 5027250 SGTC_1588 farnesol 29.9 µM -0.199214577232739 0.432018884231957 no 1927 0.421047448488389 614 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1097 itavastatin 7.23 µM -0.199880442442709 0.431788263759099 no 1928 0.420787043229035 629 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.199909551526688 0.431778182442536 no 1929 0.42077566009543 662 6708760 SGTC_425 3825-7017 13.1 µM -0.200657529480152 0.431519151329852 no 1930 0.420483185385931 642 3397440 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.201397931841738 0.431262772707991 no 1931 0.420193716116485 649 5282362 SGTC_1574 spiramycin 23.7 µM -0.20273605731318 0.430799494443832 no 1932 0.419670669354178 627 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1635 st007035 42.4 µM -0.203758113709788 0.430445707933677 no 1933 0.419271263256478 633 3716403 SGTC_199 4063-0024 41.6 µM -0.204566238941463 0.43016601355419 no 1934 0.418955517481635 645 306215 SGTC_1753 st043925 64 µM -0.204784717227199 0.430090403625514 no 1935 0.418870163929226 650 670181 SGTC_2347 9049783 174.81 µM -0.205647120358092 0.429791972298312 no 1936 0.418533283694358 683 6467988 YPL169C MEX67 SGTC_1310 1188-0297 994 nM -0.206706221873005 0.429425529135819 no 1937 0.418119648996321 641 1588352 SGTC_2689 tacrolimus 100 µM -0.206924275945466 0.429350091191872 no 1938 0.418034498668063 634 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1332 1480-0653 17.5 µM -0.206945605864107 0.429342712035911 no 1939 0.41802616952023 643 5749438 SGTC_3047 9092122 49.47 µM -0.208157535610951 0.428923481560458 no 1940 0.417552981989278 664 17173831 SGTC_2082 5219693 150 µM -0.209240217513715 0.428549028258573 no 1941 0.417130359088122 654 2834649 SGTC_1899 st063254 59.6 µM -0.209879826858039 0.428327844977038 no 1942 0.416880733701752 647 3093813 SGTC_2421 5690543 90.72 µM -0.210077281866547 0.42825956761314 no 1943 0.416803678141608 668 3397993 SGTC_259 usnic acid 108.925 µM -0.210405187513195 0.428146186867183 no 1944 0.416675722112991 697 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1151 3909-8316 15.3 µM -0.21121984389125 0.427864526811791 no 1945 0.416357863432098 681 800431 SGTC_3314 9135860 59.4275 µM -0.211692362010455 0.427701174788771 no 1946 0.416173523647531 627 25252478 SGTC_1830 st055982 50.3 µM -0.212449019901662 0.427439619958846 no 1947 0.415878373063853 671 455313 An antimicrobial agent. SGTC_1780 st038448 24.544 µM -0.212691076591998 0.427355954662736 no 1948 0.415783963686171 681 728868 YDL195W SEC31 SGTC_2427 5545055 42.75 µM -0.212876375220505 0.427291909623353 no 1949 0.415711694941134 650 5372858 SGTC_329 k048-0121 21.3 µM -0.213175704319507 0.427188456112135 no 1950 0.415594958932371 645 6832902 SGTC_2394 5221648 200 µM -0.213245830864407 0.427164219842763 no 1951 0.415567611204616 650 788586 SGTC_1467 k284-1082 293 µM -0.213317414693014 0.427139480208564 no 1952 0.415539695591776 666 3334705 SGTC_48 0382-0018 55 µM -0.214243267858907 0.426819527808033 no 1953 0.415178678223236 638 762596 SGTC_537 1334-0398 209 µM -0.214560739896622 0.42670982824489 no 1954 0.415054903013292 657 5846986 SGTC_1142 3253-1408 9.78 µM -0.215157819160969 0.426503528321251 no 1955 0.414822138080237 645 256655 SGTC_1669 st015249 58.4 µM -0.216430350208095 0.426063916742477 no 1956 0.414326155400799 649 722793 SGTC_2954 9074818 52.69 µM -0.218010694368652 0.42551809525988 no 1957 0.41371038946595 678 16648742 SGTC_647 0140-0236 81 µM -0.218600077075675 0.425314569912911 no 1958 0.413480796377321 653 990837 SGTC_307 1501-1223 22.3 µM -0.218723187761905 0.425272059902036 no 1959 0.413432842538824 665 2830329 SGTC_2163 5671233 125 µM -0.219197598467705 0.425108254434447 no 1960 0.413248063071505 618 701023 SGTC_1165 k072-0275 30.3 µM -0.220770033305207 0.424565413616328 no 1961 0.412635748915226 634 6153523 YGL055W OLE1 SGTC_2055 5235184 200 µM -0.220934194235352 0.424508749701029 no 1962 0.412571836037803 676 2836034 SGTC_508 roscovitine 141 µM -0.224135839645656 0.423403941594001 no 1963 0.41132580290377 640 160355 A CDKinase inhibitor. SGTC_2890 9046729 58.44 µM -0.224194650602138 0.423383653001153 no 1964 0.411302922870735 655 903329 SGTC_169 k015-0017 16.025 µM -0.226160100521769 0.422705729617672 no 1965 0.410538450905793 698 1840002 SGTC_823 0417-1665 178 µM -0.226371115799304 0.422632959754502 no 1966 0.410456395562439 685 3429856 SGTC_2477 5967686 25.23 µM -0.226460202279518 0.42260223854879 no 1967 0.410421754594473 646 776118 SGTC_1470 k295-0292 231 µM -0.226476963576437 0.422596458518394 no 1968 0.410415237100572 639 5045612 SGTC_1656 st012921 11 µM -0.229015795718985 0.421721150981304 no 1969 0.409428319576885 635 6732821 SGTC_2690 usnic acid 100 µM -0.230072234021439 0.421357038743584 no 1970 0.409017820108989 687 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1522 st012842 45.6 µM -0.230378127162199 0.421251622092044 no 1971 0.408898978038377 655 3491067 YOR116C RPO31 SGTC_2386 9075165 157.42 µM -0.230530129141416 0.421199241389424 no 1972 0.408839927098732 640 16452277 SGTC_2033 5192550 145 µM -0.230914725824894 0.421066713526936 no 1973 0.408690525159686 630 182073 SGTC_1039 k821-0043 94 µM -0.231137594174776 0.420989919593082 no 1974 0.408603954915197 668 15992768 SGTC_1058 3448-5425 97.3 µM -0.232789958008556 0.420420657156744 no 1975 0.407962255540286 643 7279705 SGTC_2583 asiatic acid 100 µM -0.233109013371301 0.420310757255709 no 1976 0.407838378016017 662 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_467 ro 31-8220 72.8 µM -0.233882195536335 0.420044457338624 no 1977 0.407538217908136 654 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2129 girgensonine 121.053 µM -0.234243470980152 0.41992003914858 no 1978 0.40739798433298 672 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3291 9121177 71.43 µM -0.234621757580632 0.419789771132527 no 1979 0.407251160383496 665 17015612 SGTC_1101 ebselen 5.29 µM -0.234856097237626 0.419709077566186 no 1980 0.407160212933136 670 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1260 0700-1617 7.75 µM -0.237071478667095 0.418946390481422 no 1981 0.406300669213708 629 2853078 SGTC_791 1348-1292 225 µM -0.237101413288525 0.418936086998844 no 1982 0.406289057989978 670 5437054 SGTC_2396 5342950 42.78 µM -0.238880243859643 0.418323914417143 no 1983 0.405599222623347 630 1886677 SGTC_2274 7947094 46.08 µM -0.239624805955146 0.418067737012595 no 1984 0.405310566292471 644 2971028 SGTC_372 0155-0182 15.9 µM -0.240103270201983 0.417903132775399 no 1985 0.405125099552195 648 771486 SGTC_1088 bifonazole 369 nM -0.24158940440121 0.417391955500451 no 1986 0.404549166496466 660 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2205 7238770 200 µM -0.242898231684507 0.416941881058044 no 1987 0.404042117733904 661 279867 SGTC_2566 crystal violet carbinol 226 nM -0.243070685043226 0.416882586569117 no 1988 0.403975320106781 704 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1951 sophoraflavanone G 9.2 µM -0.243927529547433 0.416588006526181 no 1989 0.40364347378003 655 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_852 0418-0143 439 µM -0.245909062614676 0.415906942288493 no 1990 0.402876314130593 656 5369229 SGTC_473 2-arachidonoylglycerol 10 µM -0.248311708891256 0.415081477871721 no 1991 0.401946620136191 639 5282280 An endocannabinoid. SGTC_842 0271-0008 11.1 µM -0.248626399868953 0.414973388841706 no 1992 0.401824892730944 651 1221709 SGTC_3208 9114115 49.47 µM -0.249042528583193 0.41483046819255 no 1993 0.401663942243486 697 650895 SGTC_1254 0550-0035 264 µM -0.249230904425961 0.414765773652278 no 1994 0.401591087616503 680 15121435 SGTC_931 2812-0076 566 µM -0.250251502488901 0.414415306508859 no 1995 0.401196429381547 648 3450959 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.251028487353993 0.414148540309988 no 1996 0.400896042240994 675 688667 SGTC_463 ikarugamyin 104 µM -0.251231707560832 0.414078774202969 no 1997 0.400817485713892 666 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2456 5770359 74.46 µM -0.251919490449197 0.413842676401828 no 1998 0.400551647069095 673 3118787 SGTC_152 4469-0003 551.229 µM -0.25249016384475 0.413646802847526 no 1999 0.400331107997218 655 697280 SGTC_1330 1469-0054 61.8 µM -0.254654411150225 0.412904158864306 no 2000 0.399495015084299 673 7102664 SGTC_2955 9076254 12.21 µM -0.256665153572546 0.412214468001292 no 2001 0.398718636983839 652 16459619 SGTC_3319 9138450 16.7555 µM -0.256830175702357 0.412157876906451 no 2002 0.398654937187266 680 2029690 SGTC_2309 7664088 163.95 µM -0.256848803021201 0.412151489148395 no 2003 0.398647747070128 684 704922 SGTC_688 0527-0193 473 µM -0.25717699480894 0.412038948067322 no 2004 0.398521071176768 659 4007154 SGTC_2466 5983409 37.09 µM -0.257380153766996 0.411969285936346 no 2005 0.398442660974486 678 2879657 SGTC_620 0109-0052 432 µM -0.257532345306078 0.411917102080764 no 2006 0.398383924584947 655 493037 SGTC_2283 7944793 200 µM -0.257541007958472 0.411914131853412 no 2007 0.398380581413626 633 2970533 SGTC_2585 alliin 100 µM -0.258156070212958 0.411703253843202 no 2008 0.398143229951067 688 87310 A garlic compound which reacts with lipids. SGTC_2452 5863136 48.41 µM -0.258795431761054 0.411484071697446 no 2009 0.39789654138096 659 2184096 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.258941652183997 0.411433949154913 no 2010 0.397840130039144 651 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2687 chenodiol 100 µM -0.259663259566989 0.411186612301687 no 2011 0.397561767666147 648 5702181 A cholesterol synthesis inhibitor. SGTC_2928 9011484 9.79 µM -0.260173723438428 0.411011667931258 no 2012 0.397364886070695 681 2994751 SGTC_552 k242-0005 476 µM -0.260353524880484 0.410950051230595 no 2013 0.397295544400233 687 4088318 SGTC_318 1488-0629 67.2 µM -0.260887038876495 0.41076723264131 no 2014 0.397089810148715 673 3662576 SGTC_2186 6124449 200 µM -0.26268509045172 0.410151239467763 no 2015 0.396396654712385 666 3834182 YLR033W RSC58 SGTC_540 1187-0821 17.3 µM -0.263289910440215 0.409944084369898 no 2016 0.396163567866325 697 847520 SGTC_2213 7173844 200 µM -0.264403098678615 0.409562875309552 no 2017 0.395734662032272 651 892728 SGTC_216 k038-0035 28.382 µM -0.264613814351137 0.409490725765249 no 2018 0.395653488535094 651 4444231 YPR107C YTH1 SGTC_977 1348-1378 135 µM -0.265049593721003 0.409341523606494 no 2019 0.395485628647912 650 X977 SGTC_87 0100-0052 35.5 µM -0.266275601013506 0.408921833684297 no 2020 0.395013481276012 665 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2878 9043973 25.97 µM -0.266697592113536 0.408777400749311 no 2021 0.394851004003477 655 6465167 SGTC_725 1497-0963 19 µM -0.267449759716167 0.408519990564508 no 2022 0.394561445765082 644 3549977 SGTC_1008 4106-0037 6 µM -0.268466469520756 0.408172110296275 no 2023 0.394170140626191 713 2905394 SGTC_643 k048-0106 28.4 µM -0.269238115426555 0.40790813006548 no 2024 0.393873225466689 663 6763920 SGTC_721 1187-1332 279 µM -0.271396495605991 0.407169970082016 no 2025 0.393043048520323 681 25730 SGTC_2434 5670830 169.91 µM -0.271717106438945 0.40706035012516 no 2026 0.392919773481879 678 1549830 SGTC_1268 0828-0275 2.46 µM -0.271860229383423 0.407011417350499 no 2027 0.392864746098635 680 745337 SGTC_1623 st003709 20.3 µM -0.271918146018363 0.406991616453986 no 2028 0.392842479132312 632 16192618 SGTC_3131 9127911 49.47 µM -0.271926880176111 0.406988630386871 no 2029 0.392839121177651 700 45595681 SGTC_363 0455-0021 3.06 µM -0.272559059875139 0.406772512752354 no 2030 0.392596093090499 674 4597466 SGTC_937 3122-0005 46.7 µM -0.273341567262804 0.406505043255428 no 2031 0.392295332709944 652 759535 SGTC_413 propylparaben 100 µM -0.273376252628233 0.406493188430591 no 2032 0.392282002714768 673 7175 A pharmaceutical preservative. SGTC_310 1273-0058 1.06 µM -0.274249955191433 0.406194601137935 no 2033 0.391946270242118 665 2734232 SGTC_1715 st032160 10.2275 µM -0.275681890034758 0.405705356353874 no 2034 0.391396203233567 696 5289825 SGTC_447 ml7 120 µM -0.275893482506513 0.40563307467261 no 2035 0.391314939960982 673 4216 Selective myosin light chain kinase inhibitor. SGTC_1725 st036284 20.55 µM -0.2759502732087 0.40561367506196 no 2036 0.391293129981406 664 707914 SGTC_231 b-estradiol 524 µM -0.276051090969346 0.405579236451525 no 2037 0.391254412631593 653 450 A steroid. SGTC_422 cantharidin 155 µM -0.276221718913841 0.405520952857692 no 2038 0.391188888320762 647 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1843 st055809 45.5 µM -0.277097071904763 0.405221980180439 no 2039 0.39085278505545 669 16413835 SGTC_3125 9127534 49.47 µM -0.277969725812508 0.404923984404792 no 2040 0.390517799276225 645 1639235 SGTC_1372 2752-0194 270 µM -0.278354093342275 0.404792747212492 no 2041 0.390370277818579 679 823334 SGTC_704 1310-0270 142 µM -0.27902836292173 0.404562552690098 no 2042 0.390111529188685 701 5718033 SGTC_2649 anisomycin 9.56 µM -0.27959152182248 0.404370316480759 no 2043 0.389895456200187 690 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1300 1094-0077 113 µM -0.27966955058633 0.404343682916279 no 2044 0.389865520780801 665 5532636 SGTC_2313 7726885 200 µM -0.283180153897636 0.403145868831938 no 2045 0.388519370430571 660 726423 SGTC_1921 5740136 50 µM -0.28578945444193 0.402256166009965 no 2046 0.387519692779711 703 1774243 SGTC_2891 9063876 19.48 µM -0.287170055493963 0.401785621832516 no 2047 0.386991056677741 660 6472478 SGTC_2021 4019055 173 µM -0.287545108366859 0.40165781877163 no 2048 0.386847484012949 696 44827708 YER133W GLC7 SGTC_2140 5586273 200 µM -0.287691921315488 0.401607793637623 no 2049 0.386791287282444 652 854421 SGTC_210 3551-0445 56.827 µM -0.288724147492266 0.401256117823179 no 2050 0.38639624113932 706 2865180 YOR207C RET1 SGTC_2952 9073731 13.78 µM -0.291100975335966 0.400446645519306 no 2051 0.385487047002327 695 16457353 SGTC_1827 berberine 7.24 µM -0.292957936099754 0.399814520693278 no 2052 0.384777151935311 691 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_418 lividomycin a 100 µM -0.295797659030559 0.398848363571077 no 2053 0.383692305433607 669 72394 An antibiotic. SGTC_690 glyoxal 20.3 µM -0.295893576700813 0.398815740345666 no 2054 0.383655678298076 678 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2780 5215298 71.43 µM -0.297299651964146 0.398337591563798 no 2055 0.383118873664808 713 2834131 SGTC_143 4032-1194 15.74 µM -0.297751890607587 0.398183836066269 no 2056 0.382946267813429 667 1806963 SGTC_487 nimodipine 119 µM -0.299450640702302 0.397606423624056 no 2057 0.382298114009085 686 4497 L-type voltage-gated calcium channels inhibitor SGTC_789 1309-1135 70.6 µM -0.300406965873372 0.397281463177888 no 2058 0.381933375464421 665 3092424 SGTC_2655 perillic acid 100 µM -0.300882322468821 0.397119962943542 no 2059 0.381752115348013 684 5702197 An apoptosis inducer. SGTC_1204 4049-0315 18.3 µM -0.303236558132435 0.396320382639069 no 2060 0.380854795208172 674 588402 SGTC_1481 3346-2004 36 µM -0.303353670665538 0.396280618503842 no 2061 0.380810174288633 706 2770522 SGTC_2335 9018011 154.17 µM -0.303586454987992 0.396201582624607 no 2062 0.380721486093278 679 6458208 SGTC_896 0964-0007 44.5 µM -0.306474070619677 0.395221523290031 no 2063 0.379621859631722 671 6756758 SGTC_2724 maprotiline 69.64 µM -0.30674445808422 0.395129787364636 no 2064 0.379518943661961 670 4011 A tricyclic antidepressant. SGTC_398 bronopol 33.3 µM -0.311544178613696 0.393502330119653 no 2065 0.377693481513421 683 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_955 1216-0110 33 µM -0.312934408164967 0.393031286268519 no 2066 0.37716524777971 659 3619719 SGTC_862 0452-0056 10.2 µM -0.313003672664319 0.393007821847582 no 2067 0.377138935936327 689 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_760 0568-0725 82.9 µM -0.3134312166861 0.392862993303091 no 2068 0.376976535334411 702 3916171 SGTC_1670 st016595 4.04 µM -0.314036118387312 0.392658111010643 no 2069 0.376746803425997 687 597879 SGTC_2679 rapamycin 1 nM -0.315886162580159 0.392031679467575 no 2070 0.376044457619815 699 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1974 st069448 26.9 µM -0.318313367151988 0.391210243858629 no 2071 0.375123622858652 682 6323587 YNR016C ACC1 SGTC_1241 0364-0022 50.8 µM -0.318798973470399 0.391045958867542 no 2072 0.374939478373959 681 4563895 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.323192827006317 0.389560365734218 no 2073 0.373274606443313 711 229346 A bile salt which induces apoptosis. SGTC_1281 0884-0031 11.8 µM -0.323566781180564 0.389434003317312 no 2074 0.373133020419587 674 1548255 SGTC_2080 5212524 12.4 µM -0.324667755617621 0.389062042252517 no 2075 0.372716270495999 690 260183 SGTC_1627 st003713 25.6 µM -0.3258053691124 0.388677809567324 no 2076 0.372285808117715 677 16195070 YER133W GLC7 SGTC_2058 5236698 133 µM -0.326655666204865 0.388390690022935 no 2077 0.371964167742736 668 766665 SGTC_954 1189-0853 2.85 µM -0.327048381818987 0.388258102443843 no 2078 0.371815646045041 688 2828194 SGTC_2000 st075254 36.4 µM -0.327860949587005 0.387983806881996 no 2079 0.371508400428773 662 17234175 SGTC_1454 4239-0054 42.6 µM -0.328340863841622 0.387821830201047 no 2080 0.371326975163474 721 1340767 SGTC_265 mycophenolic acid 32.932 µM -0.330299958212211 0.387160815651771 no 2081 0.370586662254134 710 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1870 st057514 26.5 µM -0.333427988898159 0.386106071107615 no 2082 0.369405619322777 665 5393161 SGTC_2879 9041815 71.43 µM -0.333793082440502 0.385983019438339 no 2083 0.369267851879738 687 4942971 SGTC_1325 1431-0015 227 µM -0.333889659282992 0.385950470953931 no 2084 0.369231411575451 685 1103340 SGTC_120 rhodamine 6G 52.259 µM -0.335175236165141 0.385517280299677 no 2085 0.368746450680626 719 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_3101 9120531 49.47 µM -0.335392613641887 0.385444046430992 no 2086 0.368664469544267 752 24824904 SGTC_858 0438-0351 2.77 µM -0.335832264918602 0.385295941622365 no 2087 0.368498678957792 693 2799119 SGTC_1512 0259-0544 12.2 µM -0.336530058224993 0.385060911163242 no 2088 0.368235594398594 665 18476 SGTC_963 1269-2853 151 µM -0.33678020668723 0.384976666535377 no 2089 0.368141297555112 667 3668223 SGTC_2044 5102272 200 µM -0.337671221367643 0.384676636071366 no 2090 0.367805482106143 684 592666 SGTC_137 0438-0332 85.389 µM -0.338459010649538 0.384411422101992 no 2091 0.367508655521585 723 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2331 7980721 200 µM -0.338574510778593 0.384372542837648 no 2092 0.367465143541041 679 2981221 SGTC_619 1652-1634 108 µM -0.339114449703386 0.384190805850741 no 2093 0.367261756718399 704 5400454 SGTC_560 2332-1943 155 µM -0.339400853376408 0.384094416129446 no 2094 0.367153887899772 694 21177716 SGTC_3077 9117319 49.47 µM -0.340042193501302 0.383878597852444 no 2095 0.366912376656707 714 17154678 SGTC_3181 9108277 49.47 µM -0.341677133850037 0.383328584801955 no 2096 0.366296941055389 721 17097298 SGTC_440 fluspirilene 35.1 µM -0.343451943303653 0.382731784257679 no 2097 0.365629244063629 703 3396 An atypical antipsychotic. SGTC_2077 5212015 200 µM -0.344269434693015 0.382456986708999 no 2098 0.365321834259182 706 780900 SGTC_912 3474-0017 2.18 µM -0.344799081767176 0.382278978841471 no 2099 0.36512271171883 727 3360550 SGTC_1398 3558-0053 112 µM -0.345156552368734 0.382158851427186 no 2100 0.364988340032283 678 4532369 SGTC_1416 3966-0321 25.3 µM -0.346074791890612 0.381850330543344 no 2101 0.364643253703835 705 582530 YLR208W SEC13 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.346151600536812 0.381824526871309 no 2102 0.364614392983611 688 4330530 SGTC_1569 carminic acid 40.6 µM -0.347476374394391 0.381379555133102 no 2103 0.36411673230236 678 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1427 4048-4900 550 nM -0.34943578075321 0.380721707347519 no 2104 0.363381087545098 721 24132586 SGTC_870 0573-2213 57.6 µM -0.349800564101625 0.38059927360528 no 2105 0.363244187831526 684 3916321 SGTC_1746 st038117 42 µM -0.349835141204802 0.380587668969555 no 2106 0.363231212280365 691 2898218 SGTC_1812 st052057 4.327 µM -0.350634796550451 0.380319321683187 no 2107 0.36293117402224 692 3645418 SGTC_715 0868-0130 184 µM -0.350638174611091 0.380318188200119 no 2108 0.362929906720198 695 2876258 SGTC_2927 9011802 47.9 µM -0.351026934320821 0.380187749644294 no 2109 0.362784070945086 704 43912568 SGTC_952 1185-0122 232 µM -0.35102934887853 0.380186939542664 no 2110 0.362783165232072 700 678600 SGTC_1475 4092-1048 11.7 µM -0.351866782240376 0.379906006299642 no 2111 0.362469086007267 714 2881759 SGTC_2257 7960413 200 µM -0.352321048932837 0.379753640236959 no 2112 0.362298752069431 692 2974689 YIL048W NEO1 SGTC_1983 st071813 46.9 µM -0.353436030450259 0.379379742310582 no 2113 0.361880789075637 705 11838595 SGTC_3280 9140961 49.47 µM -0.353661006664627 0.37930431244562 no 2114 0.361796474237097 704 4901226 SGTC_2760 etidronate 98.04 µM -0.353698836229026 0.379291629427357 no 2115 0.36178229742545 684 3305 A chelator and antioxidant. SGTC_1315 1237-0019 3.69 µM -0.354639859035903 0.378976177036768 no 2116 0.361429705684196 692 825140 SGTC_3309 9129340 25.759 µM -0.354785851310507 0.378927244299691 no 2117 0.361375014388548 680 17158987 SGTC_2290 7904846 200 µM -0.355369289575059 0.378731710652057 no 2118 0.361156476356732 691 2962154 SGTC_965 1291-5240 308 µM -0.355452650959913 0.378703775429365 no 2119 0.361125255443116 725 2834598 SGTC_3248 9135562 49.47 µM -0.35744070681905 0.378037746375187 no 2120 0.360380953574024 692 17650701 SGTC_2463 5473429 200 µM -0.357724606939194 0.377942665020648 no 2121 0.360274708199572 704 5399405 SGTC_51 1013-0126 23.419 µM -0.357851326839712 0.3779002274819 no 2122 0.36022728865414 736 1627850 SGTC_1295 1013-0063 9.78 µM -0.358917158024772 0.377543347020588 no 2123 0.359828531728577 704 6826038 SGTC_1456 k015-0012 13 µM -0.359530834160437 0.377337912513017 no 2124 0.359599007674204 707 2989616 SGTC_2821 7996764 71.43 µM -0.359991664187347 0.377183667652177 no 2125 0.359426683635441 659 2987135 SGTC_2411 st077133 39.94 µM -0.360641866935886 0.376966070995738 no 2126 0.359183593670534 749 1403142 YNL221C POP1 SGTC_2737 bleomycin 30.5 nM -0.362163824176797 0.376456886111771 no 2127 0.358614805649323 705 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2870 9038528 12.99 µM -0.362760777371291 0.376257228520586 no 2128 0.358391796967356 715 6463316 SGTC_2899 9053889 58.44 µM -0.363664535046342 0.375955019802907 no 2129 0.358054264742664 719 6470052 SGTC_333 3486-0131 40.1 µM -0.365083490737955 0.375480686863452 no 2130 0.357524542057008 707 6744690 SGTC_1457 k015-0032 57.3 µM -0.365367041797164 0.375385923065442 no 2131 0.357418720005262 718 4302660 SGTC_2747 doxorubicin 7.63 µM -0.365517507272662 0.375335640008063 no 2132 0.357362570318804 685 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_429 1112-0049 25.5 µM -0.367850516275265 0.374556258745611 no 2133 0.35649234965236 684 2836170 SGTC_2488 5268135 45.7 µM -0.3693367103375 0.374060037252295 no 2134 0.355938382955023 729 1270356 YLR208W SEC13 SGTC_2415 st077333 57.7 µM -0.369788506398909 0.373909229543875 no 2135 0.35577003986741 708 2766255 SGTC_691 1548-0686 185 µM -0.369836940006735 0.373893063745318 no 2136 0.355751994758187 698 46495133 SGTC_1795 st049545 62.3 µM -0.370600729756646 0.37363816120184 no 2137 0.355467469221958 675 5291882 SGTC_589 1227-0070 34.1 µM -0.371767177268439 0.373248984791788 no 2138 0.355033101809532 688 2841384 SGTC_1405 3909-7894 12 µM -0.372310536160329 0.373067741307681 no 2139 0.354830827439139 710 7104060 SGTC_3209 9113616 49.47 µM -0.372796081724354 0.372905805872828 no 2140 0.354650109655621 732 16649353 SGTC_2407 paclitaxel 400 µM -0.373605216693332 0.372635999280836 no 2141 0.354349026100344 773 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2662 daunorubicin 22.37 µM -0.373939169249917 0.372524660787366 no 2142 0.354224787045239 689 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2716 st080858 38.6235 µM -0.377069692587015 0.371481475487603 no 2143 0.353060906734567 703 5296050 SGTC_2911 7942208 15.64 µM -0.378112445537994 0.371134207624226 no 2144 0.352673531631063 703 1243384 SGTC_1498 4478-3555 97.6 µM -0.379193586697986 0.370774266106958 no 2145 0.352272056832314 720 3437919 SGTC_2808 7946468 45.46 µM -0.379260952598594 0.37075184189141 no 2146 0.352247046381507 741 2970879 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.37993108036876 0.370528799101237 no 2147 0.351998287699279 712 88881 An O-methylated flavonoid and antioxidant. SGTC_3262 9137218 49.47 µM -0.380043880415715 0.37049125943722 no 2148 0.351956421325105 707 17650664 SGTC_3330 9141424 71.43 µM -0.380380407541233 0.370379271110322 no 2149 0.351831528048916 690 27261020 SGTC_3200 9114385 49.47 µM -0.380522229372916 0.370332079423814 no 2150 0.351778899357955 717 17018030 YLR208W SEC13 SGTC_1597 7-benzyloxygramine 47.5 µM -0.380862470016455 0.370218871175669 no 2151 0.351652650973399 726 260807 SGTC_149 3970-0822 46.1 µM -0.380927735498484 0.370197156680605 no 2152 0.351628435684229 709 3114250 YBL034C STU1 SGTC_1311 1190-0148 100 µM -0.381165025304981 0.37011821141576 no 2153 0.351540399712631 713 1961333 SGTC_550 4123-0385 25.7 µM -0.381292013181993 0.370075965360444 no 2154 0.351493289702886 735 5731123 SGTC_2741 miltefosine 3.04 µM -0.382367113740105 0.369718366065476 no 2155 0.3510945399651 722 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.382976151878708 0.369515838129776 no 2156 0.350868723277113 717 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2471 5466956 24.79 µM -0.383238993409247 0.369428444680045 no 2157 0.350771284226237 716 724419 SGTC_3312 9133330 71.43 µM -0.384736457495458 0.368930674444547 no 2158 0.350216340648027 734 17617324 SGTC_2228 7354201 200 µM -0.385062659976339 0.368822270991662 no 2159 0.350095495987513 718 753451 SGTC_1037 k284-1091 78.7 µM -0.385451134720679 0.368693186864346 no 2160 0.349951601805469 712 3334711 SGTC_2352 9027995 87.8 µM -0.385551897574203 0.368659707351177 no 2161 0.349914281949074 702 2997347 SGTC_1015 4130-4525 82 µM -0.386565830032041 0.368322873198555 no 2162 0.349538829331073 707 1363237 SGTC_253 dyclonine 31.25 µM -0.387754548027427 0.367928103149972 no 2163 0.349098842146138 704 3180 An oral anasthetic. SGTC_920 mycophenolic acid 780.421 nM -0.389960647885634 0.367195833155383 no 2164 0.348282823141772 710 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1476 4112-3294 3.34 µM -0.390673810260985 0.366959216537722 no 2165 0.348019179906127 720 704369 SGTC_2378 9074213 121.43 µM -0.391023524590968 0.366843205009172 no 2166 0.34788992367227 712 657714 SGTC_1706 st031321 9.9705 µM -0.392062163998277 0.366498726528383 no 2167 0.347506141396084 710 6103185 SGTC_2738 aclarubicin 5.55 µM -0.392603821482162 0.366319121308654 no 2168 0.347306058307943 708 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_274 sirtinol 40.1 µM -0.3937030906906 0.365954710730847 no 2169 0.34690012962506 699 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1540 guanosine 70.6 µM -0.394643617230619 0.365643019708461 no 2170 0.346552959481661 716 6802 Guanosine is a purine nucleoside SGTC_1699 st031318 29.054 µM -0.395097561280938 0.365492614115137 no 2171 0.346385444293678 726 5340658 SGTC_222 nsc-310342 10.666 µM -0.396539086917737 0.365015129645885 no 2172 0.345853689418264 743 432556 SGTC_639 0833-0042 114 µM -0.397106918507202 0.364827101064958 no 2173 0.345644309145613 735 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_833 3852-0053 558 µM -0.398038073046131 0.364518834127176 no 2174 0.345301060620576 741 3123681 SGTC_486 niguldipine 82 µM -0.400766361672092 0.363616115052636 no 2175 0.344296073550134 701 1236 A calcium channel blocker. SGTC_2469 5655019 90.81 µM -0.402678579972116 0.362983862904487 no 2176 0.343592346809717 739 2788239 SGTC_1778 st046819 58.9 µM -0.403259307315436 0.362791926154399 no 2177 0.343378737043432 725 671715 SGTC_3028 9087778 49.47 µM -0.405337813032956 0.362105239992562 no 2178 0.342614607631007 692 17217395 SGTC_232 clozapine 119 µM -0.405458244460608 0.362065466044008 no 2179 0.342570352637564 706 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_686 1319-0111 510 µM -0.405482971854716 0.362057299704658 no 2180 0.34256126631778 771 4562600 SGTC_1906 st060206 94.7 µM -0.406555635965425 0.36170310777915 no 2181 0.342167193288645 752 5133468 SGTC_2188 6126565 140.678 µM -0.406682145977964 0.36166134218409 no 2182 0.342120727632576 726 874518 SGTC_606 k015-0008 38.6 µM -0.407014046301911 0.361551777548614 no 2183 0.341998835868524 739 1970475 SGTC_1979 st071809 45.3 µM -0.409591753204323 0.360701229851051 no 2184 0.34105272373888 756 4976333 SGTC_2093 5331342 194.4 µM -0.410115574355561 0.360528472342685 no 2185 0.340860584222482 723 33839 SGTC_2032 5185112 25.99 µM -0.410314005140647 0.360463036811975 no 2186 0.340787809860096 709 5718189 SGTC_1712 st032288 53.4 µM -0.41038286522297 0.360440330120926 no 2187 0.340762556854026 730 2883011 SGTC_2408 sulbentine 18.36 µM -0.411782503371505 0.359978904609486 no 2188 0.340249423413586 730 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2419 paclitaxel 166.5 µM -0.412487944573616 0.35974641564261 no 2189 0.339990907525718 733 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3287 9117173 37.0625 µM -0.412621307658802 0.359702469622134 no 2190 0.33994204375783 700 2789709 SGTC_1450 4112-4260 37.6 µM -0.413859804535824 0.359294446790641 no 2191 0.33948839135941 722 1633175 SGTC_493 zm226600 134 µM -0.414427664232387 0.359107419004396 no 2192 0.339280466177131 752 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2112 5488546 200 µM -0.41474957636733 0.359001410423055 no 2193 0.339162617873303 756 600757 SGTC_1931 st074438 57.1 µM -0.415342035052732 0.358806336796161 no 2194 0.338945766742365 762 2787313 SGTC_33 0986-0033 35.816 µM -0.415952275391074 0.358605446857598 no 2195 0.338722462970094 711 2848082 SGTC_3186 9110464 49.47 µM -0.416836587312585 0.358314402508403 no 2196 0.338398969434375 726 17018021 SGTC_645 0845-0943 5.41 µM -0.416975604003729 0.358268656877664 no 2197 0.338348126044272 725 1885106 SGTC_3049 9092223 49.47 µM -0.41917756738023 0.357544337860212 no 2198 0.337543182640118 747 8623917 SGTC_2110 5483698 200 µM -0.419716107017758 0.357367267310896 no 2199 0.337346428538604 708 2848765 YHR062C RPP1 SGTC_1909 st060837 51.5 µM -0.420844785458666 0.35699626018143 no 2200 0.336934213025639 748 678937 SGTC_2285 7945142 200 µM -0.42184115029266 0.356668858102918 no 2201 0.336570483702164 760 2970608 SGTC_2447 5741742 33.78 µM -0.422342374822403 0.356504197332971 no 2202 0.336387566263896 723 1776504 SGTC_2248 tofa 1.1 µM -0.423287047602404 0.356193929004537 no 2203 0.336042921609411 728 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_536 3852-0578 10.6 µM -0.423346901387912 0.356174273831641 no 2204 0.336021089811732 719 2869208 SGTC_3297 9117502 71.43 µM -0.424313573500809 0.355856884754905 no 2205 0.335668570727275 722 7453720 SGTC_1316 1272-0050 65.9 µM -0.425761812618725 0.355381568944319 no 2206 0.335140707837818 755 7340392 SGTC_785 1270-0111 65.3 µM -0.426026729305187 0.355294646912126 no 2207 0.335044184590399 705 6741994 SGTC_1694 st024011 44.9 µM -0.429002984199616 0.354318623773452 no 2208 0.333960526485258 755 2787533 SGTC_2657 nystatin 74.44 µM -0.429637571462295 0.354110642775907 no 2209 0.333729651053142 729 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2645 abamectin 100 µM -0.430264425788382 0.353905238908144 no 2210 0.333501650808559 734 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_3104 9120930 49.47 µM -0.432000271849208 0.353336669300402 no 2211 0.332870607793342 749 17014836 SGTC_746 1095-0025 46.6 µM -0.432040917842803 0.35332335977898 no 2212 0.332855837161976 750 6749286 SGTC_1527 coumarin 137 µM -0.432842656878446 0.353060867196684 no 2213 0.332564540659222 784 323 A hepatotoxic, DNA x-linker. SGTC_411 enrofloxacin 100 µM -0.432920695390425 0.353035320805714 no 2214 0.332536192257783 732 71188 A bacterial gyrase inhibitor. SGTC_3065 9113888 49.47 µM -0.43338348342469 0.352883837887341 no 2215 0.332368098781155 758 16648368 SGTC_2 0422-0095 29 µM -0.434564771439678 0.352497276452328 no 2216 0.331939185263416 706 6790840 SGTC_2693 st077581 40.7 µM -0.435700968142098 0.352125614242426 no 2217 0.331526851612541 733 25238761 SGTC_1263 0774-1208 64.8 µM -0.436194867975667 0.351964098283933 no 2218 0.331347675552964 779 906585 SGTC_1134 3477-0009 42.5 µM -0.436914333080312 0.351728865383599 no 2219 0.331086738418179 753 3973534 SGTC_2491 paeonol 100 µM -0.437972990911515 0.351382834852655 no 2220 0.330702931296868 752 11092 Increases levels of cortical cytochrome oxidase. SGTC_1040 k898-0338 155 µM -0.438737097493607 0.351133157180275 no 2221 0.330426021680139 752 20969351 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.438994413486942 0.351049091665637 no 2222 0.330332792127058 734 688788 SGTC_1073 triclabendazole 3.09 µM -0.439043870158094 0.351032934933224 no 2223 0.330314874418669 719 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1687 st020778 55.3625 µM -0.440753387227269 0.350474627761943 no 2224 0.329695771106336 716 4259299 SGTC_457 grayanotoxin iii 135 µM -0.440885805649168 0.350431394998203 no 2225 0.32964783508275 749 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1636 st007707 68.9 µM -0.440899099540049 0.350427054835672 no 2226 0.329643022793113 765 403051 SGTC_1170 0310-0127 64.8 µM -0.441137432275029 0.350349247761658 no 2227 0.329556752901829 768 774975 SGTC_1357 1503-1303 39.5 µM -0.441244019988583 0.350314452735183 no 2228 0.329518174017618 719 292895 SGTC_2688 kanamycin b 96.69 µM -0.44350919187015 0.349575296139486 no 2229 0.328698736062186 747 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2266 7929956 200 µM -0.443683263227317 0.349518517819587 no 2230 0.328635798826362 751 2967153 SGTC_1068 loratadine 26.9 µM -0.444054964579009 0.349397288131382 no 2231 0.328501422767219 738 3957 A H1 histamine antagonist. SGTC_1212 0520-0165 585 µM -0.444267368063863 0.349328020035351 no 2232 0.328424645423673 809 5403258 SGTC_121 0557-0495 61.343 µM -0.444283467118051 0.349322770086729 no 2233 0.328418826404808 744 3104427 SGTC_707 0865-0008 204 µM -0.445006848366781 0.349086903110861 no 2234 0.328157402514863 746 723043 SGTC_2222 6885208 172.143 µM -0.4451286308365 0.349047200232334 no 2235 0.328113399628187 715 609514 SGTC_82 0054-0107 293.755 µM -0.445487574386368 0.348930188962916 no 2236 0.327983718711949 743 3104697 SGTC_1946 st076057 65.1 µM -0.446988000500312 0.348441223773423 no 2237 0.327441861926567 740 953009 SGTC_1949 st076024 69.1 µM -0.449040834700011 0.347772645441077 no 2238 0.326701099826646 755 2921930 SGTC_3010 9080089 71.4286 µM -0.449446485911707 0.34764058663814 no 2239 0.326554801885655 744 17027233 SGTC_2770 toltrazuril 17.5 µM -0.452001663251684 0.346809180155296 no 2240 0.325633892114106 734 68591 Kills coccidiodes. SGTC_1195 1502-0147 41.1 µM -0.453863360263946 0.346203882994506 no 2241 0.324963588245476 739 817940 SGTC_8 0354-0001 70 µM -0.454381258738073 0.346035567402939 no 2242 0.324777219512044 741 4993152 SGTC_125 0133-0007 11.75 µM -0.45446092415824 0.346009679056912 no 2243 0.324748555344671 751 26541 SGTC_1210 3013-0140 750 nM -0.456477876053661 0.345354483583077 no 2244 0.324023188272375 751 905973 SGTC_3216 9129716 49.47 µM -0.457643753528807 0.344975965944248 no 2245 0.323604201894724 720 8056934 SGTC_3278 9139605 49.47 µM -0.458248192702468 0.344779787738071 no 2246 0.32338706994325 764 7958859 SGTC_1267 0828-0272 9.49 µM -0.458923538329613 0.344560645324115 no 2247 0.323144537484047 736 745334 SGTC_2896 9052656 71.43 µM -0.460606834412016 0.344014660946428 no 2248 0.322540353679091 759 6469436 SGTC_3042 9091578 49.47 µM -0.460651489535191 0.3440001812849 no 2249 0.322524332029681 725 25236497 SGTC_1180 1193-0155 285 µM -0.460729030661119 0.34397503870533 no 2250 0.322496512113837 766 2921347 SGTC_407 eburnamonine 100 µM -0.460958732784816 0.343900562227414 no 2251 0.322414106276277 747 3195 SGTC_1189 1431-2119 7.28 µM -0.463270721037605 0.3431512823682 no 2252 0.321585164905317 764 3107275 SGTC_1327 1436-0082 2.18 µM -0.465424259119238 0.342453907983126 no 2253 0.320813832506605 743 15992205 SGTC_1234 0326-0494 15.5 µM -0.467027223257996 0.341935172763116 no 2254 0.320240200582654 769 1547813 SGTC_2723 salbutamol 83.58 µM -0.467459038805014 0.341795483887296 no 2255 0.32008574571861 759 9884233 β2-adrenoceptor agonist SGTC_1801 st050089 28.441 µM -0.468144028341742 0.341573939684907 no 2256 0.319840797734705 743 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_3346 9158254 43.5805 µM -0.469960081912636 0.340986842967581 no 2257 0.319191768668061 765 17639500 SGTC_2102 5377816 72.7585 µM -0.471032633366352 0.340640287466551 no 2258 0.318808715559835 762 1379702 SGTC_459 nigericin 15.3 µM -0.473586881459005 0.339815518194209 no 2259 0.317897266074914 787 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1605 st000082 49.1 µM -0.475747740906818 0.339118372591488 no 2260 0.317127052303162 753 1114022 SGTC_714 4296-0578 26.1 µM -0.476055509527887 0.339019123709698 no 2261 0.317017415999697 747 1589775 SGTC_2894 9048625 32.47 µM -0.478219168434025 0.338321705073941 no 2262 0.316247110413253 777 4092861 SGTC_871 0574-0004 149 µM -0.48094345977134 0.337444364609897 no 2263 0.315278341868131 757 9551173 SGTC_2478 5763493 32.33 µM -0.484816150078932 0.336198710137058 no 2264 0.313903382789002 737 1365576 YLR208W SEC13 SGTC_877 0771-0151 33.1 µM -0.486967532777493 0.335507491065543 no 2265 0.313140669716561 755 6166523 SGTC_2591 skatole 100 µM -0.487419110028053 0.335362474100056 no 2266 0.312980676846854 783 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_378 3970-0959 8.33 µM -0.488131667781717 0.335133697224574 no 2267 0.312728290760872 776 6615653 SGTC_1850 st056238 17 µM -0.491003402420384 0.334212306198204 no 2268 0.311712020548626 770 5393177 SGTC_803 4488-1585 147 µM -0.491241039836515 0.334136105290336 no 2269 0.311627987765555 760 747204 SGTC_2351 9026858 72.31 µM -0.492270747646045 0.333805997800811 no 2270 0.311263978302502 768 1409300 SGTC_2412 st077135 33.4 µM -0.493533345417878 0.333401405106518 no 2271 0.310817892282243 789 13258915 SGTC_3259 9138485 49.47 µM -0.49501692185961 0.33292624856021 no 2272 0.310294087841491 739 17646153 SGTC_914 3820-6779 408 µM -0.496983775576475 0.332296722530032 no 2273 0.309600246292218 731 2893481 SGTC_382 3229-0966 23.2 µM -0.497189922974963 0.332230768787352 no 2274 0.309527563458105 780 5722370 SGTC_891 0929-0073 133 µM -0.498395834800895 0.331845059685972 no 2275 0.309102535985665 786 5603632 SGTC_2822 7994718 71.43 µM -0.499113011052192 0.331615756385492 no 2276 0.308849885995806 793 1018011 SGTC_312 4092-0653 6.84 µM -0.501130081542834 0.330971175376792 no 2277 0.308139788666094 775 1148278 SGTC_2549 cedrol 20.94 µM -0.501841300269634 0.330744015519674 no 2278 0.307889579428784 770 6708665 A sedative which affects the nervous system. SGTC_2183 6420625 130.508 µM -0.503595589611559 0.330183970474372 no 2279 0.307272796235247 749 2897619 SGTC_2314 7727897 200 µM -0.508138180652983 0.328735548531944 no 2280 0.30567822044679 746 900724 SGTC_1185 1319-0113 81.3 µM -0.508597410968032 0.328589263869649 no 2281 0.305517222049165 774 4672763 SGTC_1224 0823-0416 294 µM -0.512134759900796 0.327463347453652 no 2282 0.304278349330623 773 3598164 SGTC_52 0329-0193 875 nM -0.515229147073287 0.326479707810769 no 2283 0.30319645179238 790 3739292 SGTC_2761 levamisole 97.89 µM -0.518601952228193 0.325408937824579 no 2284 0.30201917370889 787 26879 An alkaline phosphatase inhibitor. SGTC_1230 0170-0365 3.77 µM -0.518667075204331 0.325388277264961 no 2285 0.301996462740194 759 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_3086 9117350 49.47 µM -0.518889307922006 0.325317776967456 no 2286 0.30191896713947 756 2679265 SGTC_2054 5233173 129 µM -0.52023383606915 0.324891377149935 no 2287 0.301450302382582 734 6889 SGTC_1499 4480-0877 67.3 µM -0.521029704640815 0.324639085662933 no 2288 0.301173039306494 755 2861909 SGTC_2611 pyromycin 23.93 µM -0.521175287200815 0.324592944480748 no 2289 0.301122333982801 758 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1835 st008666 49.2 µM -0.521378192108103 0.324528639947962 no 2290 0.301051670129165 758 690455 SGTC_573 3702-0553 84.7 µM -0.523103760652966 0.323981985104768 no 2291 0.300451024320437 760 1222756 SGTC_2244 6635614 200 µM -0.52487903718973 0.323419978806865 no 2292 0.299833641452106 771 836499 SGTC_99 0109-0120 622.8 µM -0.525473966184953 0.323231729796342 no 2293 0.299626873256083 781 759414 SGTC_3033 9090887 49.47 µM -0.526977610803051 0.322756144394134 no 2294 0.299104568211462 762 19325384 SGTC_279 1273-0055 2.93 µM -0.52728065016474 0.322660331607339 no 2295 0.298999354712672 794 2847562 SGTC_475 α-linolenic acid 10 µM -0.527350618645232 0.322638211153601 no 2296 0.298975064452854 762 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_972 1319-0219 195 µM -0.52742987483048 0.322613155161025 no 2297 0.298947550955767 777 23903702 SGTC_1583 clindamycin 39.6 µM -0.527527066547643 0.32258243014204 no 2298 0.29891381277382 782 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2332 7982454 138.89 µM -0.527792820501658 0.322498424073246 no 2299 0.298821570377715 780 2981748 SGTC_2520 obtusaquinone 4.71 µM -0.529721281208339 0.321889100299065 no 2300 0.298152595338982 782 5967872 SGTC_1880 MG-132 525 µM -0.530017437864135 0.321795567870005 no 2301 0.298049920278187 764 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2049 5262831 67.185 µM -0.531742143538607 0.32125109446293 no 2302 0.297452299505673 779 763417 SGTC_2826 7992541 19.48 µM -0.531982323413214 0.321175302360956 no 2303 0.297369119178508 822 2985066 SGTC_2171 5739187 198.077 µM -0.533297011356329 0.320760566316448 no 2304 0.296913998087145 745 2262761 SGTC_994 3910-0338 138 µM -0.533446679920564 0.320713365517063 no 2305 0.296862205761698 781 3479481 SGTC_2935 9038016 29.96 µM -0.534134773871122 0.320496399440197 no 2306 0.296624146279586 773 6463195 SGTC_3210 9128157 49.47 µM -0.536107732538727 0.319874636968098 no 2307 0.295942048151698 771 17590849 SGTC_397 arbidol 50 µM -0.536600263026066 0.3197194986564 no 2308 0.295771881201345 764 131410 A RNA synthesis inhibitor. SGTC_2198 6589944 200 µM -0.536626261579595 0.319711310452151 no 2309 0.295762900073468 751 5290268 SGTC_1274 0865-0114 173 µM -0.536671415244289 0.319697089584081 no 2310 0.2957473021636 756 870624 SGTC_1098 clofazimine 15.1 µM -0.537867463024352 0.319320498271569 no 2311 0.295334276354457 796 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_3234 9132280 49.47 µM -0.538350345839153 0.319168509066014 no 2312 0.295167599844436 765 17612295 SGTC_1558 st069300 45.6 µM -0.539542715422021 0.318793336409106 no 2313 0.294756215634317 777 24208000 SGTC_2096 5468907 200 µM -0.539996270311762 0.318650676523152 no 2314 0.294599802280637 764 759785 SGTC_1235 benzylparaben 21.5 µM -0.540935250860207 0.318355417639749 no 2315 0.294276106351305 792 7180 SGTC_1826 st055655 41.6 µM -0.541894937843864 0.318053766882062 no 2316 0.293945442117854 770 676168 SGTC_263 alizarin 107.927 µM -0.541974937082032 0.318028626805036 no 2317 0.29391788579979 788 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1480 1070-0044 41.2 µM -0.54216077344673 0.317970230228762 no 2318 0.293853877727001 775 3124987 SGTC_1602 st001878 87.6 µM -0.542278613243562 0.317933203003489 no 2319 0.293813293219039 812 595405 YLR310C CDC25 SGTC_2315 7733312 200 µM -0.543399969686487 0.31758094526017 no 2320 0.293427223287477 759 726316 SGTC_1606 st000094 49.2 µM -0.546430929159786 0.31662964052958 no 2321 0.2923848772255 769 1242210 SGTC_1647 st011722 22.4 µM -0.547870367854081 0.316178278521214 no 2322 0.291890458386012 774 2854783 SGTC_443 clozapine 122 µM -0.54848758453597 0.315984822908409 no 2323 0.291678575963679 784 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_910 3454-3003 490 µM -0.549135025901898 0.31578194804554 no 2324 0.291456394874774 793 820824 SGTC_1590 st077108 57.8 µM -0.549885480546377 0.31554686354571 no 2325 0.291198961768029 773 5489485 SGTC_1690 st023502 41.2 µM -0.55163714251666 0.314998435249854 no 2326 0.290598491769092 794 24207482 SGTC_998 3996-0085 177 µM -0.551851322014634 0.314931405679765 no 2327 0.290525110768427 787 715391 SGTC_3079 9117512 49.47 µM -0.552450578625475 0.31474389484899 no 2328 0.290319842854 810 7185044 SGTC_2619 obliquin 87.91 µM -0.552858480854332 0.314616287215858 no 2329 0.290180159869593 787 6708593 A bioactive alkalod. YER133W GLC7 SGTC_3214 9129694 49.47 µM -0.554177827379142 0.314203696142253 no 2330 0.289728575563873 802 17158655 SGTC_2804 7954240 19.48 µM -0.554962359380152 0.313958464291706 no 2331 0.28946020336528 764 828705 SGTC_939 1165-0479 45.3 µM -0.55520008051199 0.313884172771407 no 2332 0.289378906931023 774 1377347 SGTC_1846 st056244 14.8 µM -0.555651629405147 0.31374307755414 no 2333 0.289224514721752 779 5393182 SGTC_1057 3448-5381 134 µM -0.560700609035601 0.312167284674456 no 2334 0.287500825974311 766 5497911 SGTC_456 gingerol 170 µM -0.563666595584039 0.31124319384745 no 2335 0.286490527583975 813 442793 A herb. SGTC_161 4065-0411 162.148 µM -0.563934430516252 0.311159804884846 no 2336 0.286399378466253 790 1906281 YLR208W SEC13 SGTC_2621 lithochol-11-enic acid 100 µM -0.564260770084991 0.31105821391791 no 2337 0.286288337758168 807 6708711 SGTC_1719 st032227 49.2 µM -0.564350169974841 0.311030385844023 no 2338 0.286257922007604 770 3125804 SGTC_1223 0764-0573 147 µM -0.565850249440473 0.310563607802927 no 2339 0.285747791983603 779 1609797 SGTC_3352 9151559 45.5865 µM -0.565889473760759 0.310551406501847 no 2340 0.285734458824654 762 17159339 SGTC_2185 6113692 200 µM -0.566105385075785 0.310484247846674 no 2341 0.285661071394826 790 874150 SGTC_41 0478-0632 82.643 µM -0.566532402404083 0.310351443815142 no 2342 0.285515956252714 810 3750424 SGTC_703 3875-0075 71.8 µM -0.56667460431862 0.310307223959239 no 2343 0.285467638952347 805 2850814 SGTC_1640 st009078 66.4 µM -0.5670847511662 0.310179697898602 no 2344 0.285328301258639 782 690618 SGTC_521 r062-0005 13.8 µM -0.567325481923173 0.310104858640589 no 2345 0.285246533766253 776 2832033 SGTC_2334 9017922 200 µM -0.569076631638349 0.309560691681084 no 2346 0.284652068082786 789 3163164 SGTC_1226 3909-7979 35.4 µM -0.569132405399341 0.30954336692441 no 2347 0.28463314419523 790 6615510 SGTC_1587 estradiol valerate 56.1 µM -0.569160645103261 0.309534595111484 no 2348 0.284623562768477 797 13791 A steroid. SGTC_3332 9141069 11.198 µM -0.569896171237568 0.309306164313841 no 2349 0.284374060945964 790 17332883 SGTC_2250 alverine citrate 130 µM -0.570257866050955 0.309193860539557 no 2350 0.28425140682631 783 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2711 st079103 59.1 µM -0.571513550979531 0.308804117345429 no 2351 0.283825788652418 779 54693780 SGTC_539 4859-0462 2.54 µM -0.572025189322697 0.308645375212454 no 2352 0.283652454826008 775 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2194 5927483 104.545 µM -0.57292935841566 0.30836493298522 no 2353 0.283346262713997 753 760979 SGTC_1817 st052116 64.4 µM -0.574070013447294 0.308011300419124 no 2354 0.282960212113185 777 4361398 SGTC_2133 5320837 200 µM -0.575466550322131 0.307578580506887 no 2355 0.28248790335819 792 2841355 SGTC_2260 7964312 200 µM -0.579053766965899 0.306468301375803 no 2356 0.281276447218192 786 231951 SGTC_1882 5615643 20 µM -0.579634590183855 0.306288697458465 no 2357 0.281080530814325 789 2253075 SGTC_76 0433-0009 400.328 µM -0.579761895085119 0.30624933806714 no 2358 0.281037598643542 819 2841569 SGTC_509 pifithrin 175 µM -0.579946320964927 0.306192322308818 no 2359 0.280975408674342 805 4817 A p53 inhibitor. SGTC_3136 9095672 49.47 µM -0.580540415456452 0.306008688312594 no 2360 0.280775120208377 788 17217380 SGTC_2223 6903751 107.57 µM -0.580862944128401 0.305909015443812 no 2361 0.28066641428549 795 5598863 SGTC_108 0509-0257 621.132 µM -0.581839781166655 0.305607225648039 no 2362 0.280337302792747 779 536624 SGTC_2045 5106652 78.05 µM -0.582735610053285 0.305330579019138 no 2363 0.28003564857578 785 673349 SGTC_391 gliotoxin 8.33 µM -0.583699240916957 0.305033118112487 no 2364 0.279711339026615 805 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1655 st012546 55.1 µM -0.583927256850583 0.304962751252049 no 2365 0.279634627036467 786 720985 YLR208W SEC13 SGTC_1010 4112-3296 15.2 µM -0.58415968073009 0.304891031499375 no 2366 0.279556442580887 798 704384 SGTC_1190 1486-1332 13 µM -0.58799050581904 0.303710023487728 no 2367 0.27826933274725 796 4150046 SGTC_1395 3486-0190 4.35 µM -0.591497758819994 0.302630563648417 no 2368 0.277093478182996 807 6748079 SGTC_252 miconazole 1.30953 nM -0.59223263946493 0.302404600635308 no 2369 0.276847407864315 799 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2969 9091408 28.7 µM -0.59283029053989 0.302220889138091 no 2370 0.276647366976327 774 4286311 SGTC_362 0310-0100 9.03 µM -0.59410967686426 0.30182778805046 no 2371 0.276219379506221 776 790235 SGTC_3109 9122853 49.47 µM -0.595391072494612 0.301434300096247 no 2372 0.275791045826379 823 1234709 SGTC_78 0336-0123 156.75 µM -0.596101848863721 0.301216136165527 no 2373 0.275553594566523 794 6765896 SGTC_3071 9117417 49.47 µM -0.596107556269637 0.301214384636436 no 2374 0.275551688282759 798 45595590 YGL055W OLE1 SGTC_2064 5220758 200 µM -0.601737366545282 0.299488908033152 no 2375 0.273674486404934 788 788518 SGTC_102 gallobenzophenone 83.616 µM -0.602662677682572 0.299205739341555 no 2376 0.273366557460542 793 70837 SGTC_2354 9060492 162 µM -0.60365162911564 0.298903229493484 no 2377 0.273037639819473 805 6471895 SGTC_392 N-ethylmaleimide 8.33 µM -0.604399747530375 0.298674480285022 no 2378 0.272788951791849 782 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_654 1124-0271 80.9 µM -0.60440624581742 0.298672493678221 no 2379 0.272786792136634 798 5403748 SGTC_1023 4482-3888 16 µM -0.604646059613778 0.298599183834013 no 2380 0.272707097817565 804 3303168 SGTC_2467 5474540 200 µM -0.604858690322077 0.298534190565467 no 2381 0.272636446578629 778 5413519 SGTC_3 0833-0587 95.581 µM -0.604951132242365 0.298505936529071 no 2382 0.272605733546947 802 5382644 SGTC_736 0958-0254 92.6 µM -0.60521013877862 0.298426780005112 no 2383 0.272519690004541 819 6812352 SGTC_881 0833-0569 170 µM -0.605533604793915 0.298327937053432 no 2384 0.27241225157149 767 5418700 SGTC_128 0906-2981 13.371 µM -0.606526200356499 0.298024718281226 no 2385 0.272082694807552 811 6740226 SGTC_894 0960-0238 55.9 µM -0.607010956581698 0.297876685681339 no 2386 0.271921820470853 812 6741907 YDL195W SEC31 SGTC_2085 5307070 144.047 µM -0.610544759988144 0.296798563816771 no 2387 0.270750501262538 819 2840351 SGTC_2792 7535235 81.82 µM -0.610851610973119 0.296705031532078 no 2388 0.27064891101251 778 1281891 SGTC_919 tnp00227 403.569 nM -0.611284916624808 0.296572977164795 no 2389 0.270505487393411 817 1269246 A methoxyflavone. YNL221C POP1 SGTC_2513 baicalein 25.65 µM -0.611300990080843 0.296568079131217 no 2390 0.270500167830464 810 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_3225 9130819 49.47 µM -0.612503633562874 0.296201705049421 no 2391 0.270102297350885 830 4547121 SGTC_445 e6 berbamine 66 µM -0.615676572590201 0.295236096798721 no 2392 0.269054001156208 819 6610268 A calcium/calmodulin antagonist. SGTC_3103 9120822 49.47 µM -0.61599624839589 0.295138891498626 no 2393 0.268948497923214 824 17141819 SGTC_824 1304-0008 100 µM -0.617107120954164 0.294801217985185 no 2394 0.268582036038077 798 768245 SGTC_2340 7987427 183.45 µM -0.617915626770261 0.294555567365931 no 2395 0.268315478752918 786 2239331 SGTC_2152 5568786 200 µM -0.618202219429491 0.294468513783661 no 2396 0.268221023618826 809 5399883 SGTC_663 1486-0733 13.9 µM -0.618779470242359 0.294293207767788 no 2397 0.268030824246115 816 722445 YPR165W RHO1 SGTC_2759 disulfiram 3.38 µM -0.619024898026109 0.294218688105696 no 2398 0.267949978396319 797 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1783 st039459 87.517 µM -0.619260408906178 0.294147187727306 no 2399 0.26787241080014 834 729761 SGTC_945 3381-0768 11.3 µM -0.619303840127319 0.294134003019157 no 2400 0.267858107577727 811 1126236 YIL048W NEO1 SGTC_1277 0873-0036 22 µM -0.619688212117433 0.294017328532454 no 2401 0.267731538958226 806 5965735 SGTC_1177 0983-0204 23.6 µM -0.620824760674275 0.293672459271523 no 2402 0.267357464917942 801 766818 SGTC_2029 5175081 200 µM -0.620863823256927 0.293660609623336 no 2403 0.267344612876154 796 1380876 SGTC_2167 5876490 200 µM -0.621504096955041 0.29346641392392 no 2404 0.267133999852522 821 686534 SGTC_1312 1218-2183 165 µM -0.622514717918249 0.29316001260768 no 2405 0.266801734526269 813 6744073 SGTC_908 3448-7491 47.7 µM -0.623883978567468 0.292745115275787 no 2406 0.266351891403357 768 1203031 SGTC_1346 1488-2224 62.4 µM -0.624294105450521 0.292620896518097 no 2407 0.266217227175518 801 3722427 SGTC_1191 1487-1166 10.6 µM -0.62507368867041 0.292384844787605 no 2408 0.265961347860111 827 3955771 SGTC_2922 7999257 32.47 µM -0.625566882560406 0.292235555255401 no 2409 0.265799533279831 822 2988377 SGTC_6 0844-0013 19.835 µM -0.627277208295907 0.291718115464233 no 2410 0.265238770354511 828 1584900 SGTC_218 alverine citrate 93.75 µM -0.627589598925759 0.291623651333368 no 2411 0.265136412039496 813 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2784 7567673 72.73 µM -0.628601094339475 0.291317882057652 no 2412 0.264805121855139 806 3471247 SGTC_599 1935-0052 86.5 µM -0.629343012591894 0.291093699580678 no 2413 0.264562258831406 793 9557311 SGTC_1581 himbacine 57.9 µM -0.629673194921314 0.290993955619963 no 2414 0.264454211838393 823 5281825 An alkaloid muscarinic receptor antagonist. SGTC_3135 9127742 49.47 µM -0.631649836023349 0.290397171216516 no 2415 0.263807856982666 818 3643468 SGTC_1297 1068-0111 14.1 µM -0.631719570376469 0.290376127597679 no 2416 0.263785068807871 817 767057 SGTC_1758 st042942 75.2445 µM -0.631873587263622 0.290329652709944 no 2417 0.26373474188092 805 669317 SGTC_2358 9037157 4 µM -0.63248333295769 0.290145694992115 no 2418 0.263535547999273 806 2388925 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.633193076369655 0.289931637197058 no 2419 0.263303783244151 794 6857784 SGTC_2101 5377231 179.231 µM -0.633729264911958 0.289769972473452 no 2420 0.26312876140006 819 2844213 SGTC_2189 6047310 154.431 µM -0.634321905455368 0.289591336288046 no 2421 0.262935381763497 806 711535 SGTC_2866 9034245 58.44 µM -0.634374883124099 0.289575370055889 no 2422 0.262918098596807 797 6462273 SGTC_2647 atorvastatin 60.16 µM -0.634584423022462 0.289512223674505 no 2423 0.262849745052472 794 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2864 9034755 47.6 µM -0.635724514562709 0.289168762109808 no 2424 0.262477997622683 799 4930451 SGTC_2142 5622915 118.518 µM -0.635933782996284 0.289105739160102 no 2425 0.26240979111973 810 5322196 SGTC_2809 7964133 12.99 µM -0.637991432337735 0.288486405022576 no 2426 0.26173962863733 824 1253665 SGTC_1689 st020265 53.493 µM -0.638399587418715 0.288363628330346 no 2427 0.261606799727097 814 5758320 YPR016C TIF6 SGTC_3323 9138564 53.9225 µM -0.639081992103454 0.288158409952885 no 2428 0.261384797054993 803 43912313 YNL103W MET4 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.639589698457902 0.288005773018034 no 2429 0.261219690750362 772 4000243 SGTC_2325 6158266 200 µM -0.640286790106426 0.287796261449438 no 2430 0.260993083607794 797 3623240 SGTC_1173 0443-0020 122 µM -0.643028217550212 0.286973021868376 no 2431 0.260102895199456 806 5331295 SGTC_1813 st051246 8.6015 µM -0.643125890346745 0.286943711713854 no 2432 0.260071208072793 802 5291959 SGTC_23 0213-0011 39.996 µM -0.643501743213365 0.286830937085964 no 2433 0.259949291999456 832 627608 SGTC_2251 lansoprazole 556 µM -0.647810685177202 0.285539542591468 no 2434 0.258553701766069 816 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1548 st061468 90.8 µM -0.648670804819478 0.285282095557493 no 2435 0.258275589486447 812 390799 SGTC_1379 2144-0755 36.5 µM -0.65044367482575 0.28475179745638 no 2436 0.257702836765464 827 5392327 SGTC_1404 3909-7820 48.3 µM -0.651386013406118 0.284470118235519 no 2437 0.257398668511445 818 23741373 SGTC_3151 9099821 49.47 µM -0.65467437410797 0.283488221676681 no 2438 0.256338713818096 829 17174189 SGTC_2848 9016370 25.97 µM -0.656337653544102 0.282992189812891 no 2439 0.255803447812314 801 7894410 SGTC_2074 5212007 75.395 µM -0.657265935879464 0.282715533894959 no 2440 0.255504967768764 806 758611 SGTC_3255 9139072 49.47 µM -0.661504796619356 0.281453880854795 no 2441 0.254144319774359 822 17646060 SGTC_309 k408-0051 1.48 µM -0.664154826576654 0.280666509383606 no 2442 0.253295611219632 829 3640463 SGTC_1654 st012436 41.8 µM -0.664657451092948 0.280517290919979 no 2443 0.253134807079241 822 4323132 SGTC_2324 6149169 200 µM -0.665739672559006 0.280196132923599 no 2444 0.252788755444649 813 2888231 SGTC_165 k038-0023 64.381 µM -0.66613040917072 0.280080222451153 no 2445 0.252663874551331 820 46368543 SGTC_2249 haloperidol 116.36 µM -0.667177551373763 0.27976970649682 no 2446 0.252329364242447 825 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1993 st073995 70.8 µM -0.667778537489849 0.279591567606751 no 2447 0.252137484310597 835 3098394 SGTC_272 doxorubicin 8.13 µM -0.670187581339955 0.27887805377665 no 2448 0.251369109713109 830 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2323 6148992 148.28 µM -0.670262649475012 0.278855834237975 no 2449 0.251345186319733 826 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_408 cantharidin 100 µM -0.672629455309582 0.27815572165393 no 2450 0.250591528824876 810 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_501 nsc-95397 161 µM -0.676138092969389 0.277119429718844 no 2451 0.249476486592514 829 262093 SGTC_3107 9121808 49.47 µM -0.678847307126298 0.276320545832576 no 2452 0.248617307822139 785 662681 SGTC_2224 6650123 117.647 µM -0.679909812487261 0.276007546584436 no 2453 0.248280784055981 828 2908370 SGTC_985 1493-0307 8.71 µM -0.681500042177254 0.2755394126581 no 2454 0.24777757004181 836 3278274 SGTC_593 1203-0218 61.7 µM -0.68309689103296 0.275069723449682 no 2455 0.247272809918872 832 3666956 SGTC_1729 st035615 45.989 µM -0.684683077444012 0.274603561185382 no 2456 0.246771964961758 831 17385451 SGTC_2425 5628681 7.85 µM -0.684946517804836 0.274526176791617 no 2457 0.246688835196856 843 5714958 SGTC_100 0086-0128 49.5915 µM -0.685672001480041 0.274313124930838 no 2458 0.2464599831674 851 93297 SGTC_1732 st034308 51.822 µM -0.690232210009004 0.272975806584136 no 2459 0.245024085346088 824 830119 SGTC_794 k038-0031 316 µM -0.692629538037617 0.272274069248752 no 2460 0.2442710342443 839 6624242 SGTC_2306 7482397 179.52 µM -0.692684062977463 0.272258119333681 no 2461 0.244253921337645 860 891448 SGTC_1734 st037168 69.4 µM -0.692723498957086 0.272246583608 no 2462 0.244241544574302 831 708907 SGTC_2598 perillyl alcohol 100 µM -0.6935927691243 0.271992368319204 no 2463 0.243968814839513 832 10819 An apoptosis inducer. SGTC_1386 3228-0095 33.8 µM -0.694479417526128 0.271733192498237 no 2464 0.243690802106777 826 870181 SGTC_1125 tnp00248 1.32998 µM -0.694586943481749 0.271701769990851 no 2465 0.243657098476221 847 24207736 SGTC_2580 diallyl disulphide 81.36 µM -0.696783136107407 0.271060368613239 no 2466 0.242969260685263 826 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_376 3970-0862 59.1 µM -0.69894907393147 0.270428543748699 no 2467 0.242291928694434 854 3135186 SGTC_2895 9054447 58.44 µM -0.69945054268829 0.270282365494637 no 2468 0.242135255420143 856 2697450 SGTC_2336 9001819 198.65 µM -0.699665773827129 0.270219637688873 no 2469 0.242068027867542 839 2989602 SGTC_384 k007-0144 5.16 µM -0.700650916688785 0.269932616749283 no 2470 0.241760447238903 845 6824886 SGTC_609 0986-0026 86.3 µM -0.70076869961322 0.269898310961255 no 2471 0.241723687336014 841 2848610 SGTC_145 3737-0113 38.366 µM -0.70099659282872 0.269831940335276 no 2472 0.241652570764002 830 6849351 SGTC_3141 9094609 49.47 µM -0.701008088496911 0.269828592603527 no 2473 0.24164898371589 855 25236309 YDL196W YDL196W SGTC_2457 5731572 11.68 µM -0.701269563190083 0.269752452395364 no 2474 0.241567402328358 841 2865357 SGTC_339 3091-4833 71.4 µM -0.701411167047931 0.269711222505823 no 2475 0.241523227473258 834 3240077 SGTC_2702 st077768 96.8 µM -0.70202515617306 0.269532487740103 no 2476 0.241331737684242 816 6484119 SGTC_693 4161-2696 114 µM -0.702297561061758 0.269453208567477 no 2477 0.24124680697834 854 805759 SGTC_1563 conessine 56.1 µM -0.702364060455942 0.269433856736417 no 2478 0.241226076188637 837 441082 An anti-amoebic, histamine inhibitor. SGTC_1394 3474-0001 65.7 µM -0.704533240286412 0.268802991129124 no 2479 0.240550378491334 816 5017666 YIL048W NEO1 SGTC_3019 9081971 49.47 µM -0.704546205800685 0.268799222582132 no 2480 0.240546342845122 843 16451803 SGTC_3009 9080819 71.4286 µM -0.70501719410629 0.268662343455583 no 2481 0.240399768011948 833 17027216 SGTC_3075 9116269 49.47 µM -0.706550154018118 0.268217075648448 no 2482 0.239923037270221 842 17015205 YNL244C SUI1 SGTC_290 2043-6722 48.1 µM -0.706642948777491 0.268190134147588 no 2483 0.239894195857693 835 773758 YLR208W SEC13 SGTC_1513 0337-0559 19 µM -0.707106431232312 0.268055589686674 no 2484 0.239750169823067 836 775073 SGTC_2371 9071574 200 µM -0.707539402748745 0.267929932959913 no 2485 0.239615667623527 846 45596039 SGTC_1233 0325-0408 14.2 µM -0.709908091494739 0.267243019050407 no 2486 0.238880566197079 843 12874 SGTC_2429 5902844 64.44 µM -0.715822018863244 0.265531883091671 no 2487 0.237050627263439 843 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2145 5634607 200 µM -0.716883922401567 0.265225221514249 no 2488 0.236722861564007 848 308662 SGTC_3231 9132313 49.47 µM -0.717281443926378 0.265110469625033 no 2489 0.236600227263583 849 4905967 SGTC_3217 9129673 49.47 µM -0.717394775938174 0.265077758878469 no 2490 0.236565271052971 841 17248312 SGTC_525 k781-2675 26.7 µM -0.718946266980621 0.26463016198521 no 2491 0.236087013845042 829 3651118 YDL195W SEC31 SGTC_2595 hexamethylquercetagetin 100 µM -0.721819580942683 0.263802242697449 no 2492 0.235202704573646 861 386331 SGTC_1809 st050081 57.6 µM -0.722079175793424 0.263727507909773 no 2493 0.235122900211834 847 5036894 SGTC_1749 st037932 54.2 µM -0.723141021905544 0.263421925388325 no 2494 0.234796624405844 879 594497 SGTC_788 1182-0090 188 µM -0.723264504946156 0.263386400657705 no 2495 0.234758697750518 842 5715185 SGTC_2636 apigenin dimethyl ether 100 µM -0.724334331693279 0.263078725539936 no 2496 0.234430252341711 851 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_831 k061-1017 217 µM -0.724786032880445 0.262948874423614 no 2497 0.234291652824316 858 1240153 SGTC_1564 D-Arginine 115 µM -0.728586608815964 0.261857617146364 no 2498 0.233127286169169 852 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_86 0417-1630 471.922 µM -0.728954250258616 0.26175217980281 no 2499 0.233014824053284 843 3634867 SGTC_2357 9067248 200 µM -0.729735198847783 0.261528280763258 no 2500 0.232776030612908 861 9150235 SGTC_2593 nobiletin 86.24 µM -0.730225032156269 0.261387895069144 no 2501 0.23262632195511 845 72344 An anti-infammatory. SGTC_2998 9066762 71.4286 µM -0.730666653200613 0.261261360141724 no 2502 0.232491394394405 851 4945196 SGTC_386 1509-0011 3.07 µM -0.733639260603226 0.260410457070169 no 2503 0.23158431309662 843 3107280 SGTC_2218 6965428 192.983 µM -0.734423368780026 0.260186245786773 no 2504 0.231345374294528 840 675684 SGTC_2125 5246583 200 µM -0.741671132275279 0.258118509265583 no 2505 0.229143307137256 847 835267 SGTC_366 0181-0206 4.31 µM -0.743142511553709 0.257699777888227 no 2506 0.228697702094111 859 274874 SGTC_1382 3002-2117 298 µM -0.744573147551626 0.257292979805581 no 2507 0.228264903027207 881 1497314 SGTC_64 000l-0018 272.079 µM -0.746528976306507 0.256737384896992 no 2508 0.227673967156826 852 6811119 SGTC_3321 9137793 26.8275 µM -0.747281480472645 0.256523786528485 no 2509 0.227446834490648 859 4904192 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.749348821921816 0.255937448342354 no 2510 0.226823494349707 866 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_37 0566-0070 1.56 µM -0.749976597475224 0.255759537522543 no 2511 0.226634399814932 860 1626686 SGTC_780 0109-0199 192 µM -0.75143469713586 0.255346563138684 no 2512 0.226195543873203 844 610414 SGTC_892 0929-0076 29 µM -0.75403036549859 0.254612261055645 no 2513 0.225415494252765 859 5751038 SGTC_2751 anetholtrithion 17.25 µM -0.754059308715669 0.254604079398584 no 2514 0.225406804838467 860 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_868 0527-0199 213 µM -0.754362790357171 0.254518299621929 no 2515 0.225315704143678 857 2849450 SGTC_2327 6189656 200 µM -0.756418554781595 0.253937632041946 no 2516 0.224699143369239 864 5349088 SGTC_2812 7970281 58.44 µM -0.756602007048799 0.253885848247911 no 2517 0.224644169274307 869 2233435 SGTC_2348 9022543 33.42 µM -0.75745484410843 0.253645187364986 no 2518 0.224388704649785 845 3162678 YDL140C RPO21 SGTC_569 4130-2812 160 µM -0.757728276963836 0.253568053107789 no 2519 0.224306833630804 858 743552 SGTC_327 1273-0057 3.96 µM -0.758549458649521 0.253336475307815 no 2520 0.224061058118816 847 3108138 SGTC_2610 ononetin 44.17 µM -0.7593207619124 0.25311906479691 no 2521 0.223830350350188 874 259632 SGTC_71 0417-1750 47.813 µM -0.761791870161825 0.252423184508 no 2522 0.223092116667581 831 6811472 SGTC_1150 3909-7983 10.9 µM -0.764443051996048 0.251677717009061 no 2523 0.222301630617515 859 23965914 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.765299760305452 0.251437073930463 no 2524 0.222046533374309 853 756377 SGTC_488 nitrendipine 139 µM -0.768038734207377 0.250668532868281 no 2525 0.2212320865729 865 4507 Dihydropyridine L-type calcium channel blocker. SGTC_249 wiskostatin 11.211 µM -0.768160939010881 0.250634271888365 no 2526 0.22119578826443 842 2775510 A n-wasp and actin depolymerizer. SGTC_5 0352-0601 109.883 µM -0.768171297462987 0.250631367937184 no 2527 0.221192711665667 850 762456 SGTC_1139 k015-0024 46.9 µM -0.768544762409543 0.250526680418874 no 2528 0.221081803937011 865 2766652 SGTC_316 k060-0003 58.6 µM -0.770426057425995 0.249999679274407 no 2529 0.220523600674476 872 6152314 SGTC_1153 4055-0057 267 µM -0.774202136130891 0.248943676312728 no 2530 0.219405632635626 858 882706 SGTC_800 3448-7362 155 µM -0.774567246313599 0.248841697080874 no 2531 0.219297708900867 867 15991913 SGTC_1320 1313-0481 95.3 µM -0.774716111835795 0.248800123709953 no 2532 0.219253714166039 860 6813365 YLR208W SEC13 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.774810891819208 0.248773656623986 no 2533 0.219225706158122 890 5393153 SGTC_1201 1889-3372 45.9 µM -0.775061306704265 0.248703736073521 no 2534 0.219151717074082 845 5392199 SGTC_3342 9147791 14.508 µM -0.776319634997669 0.248352545606097 no 2535 0.218780141246597 857 1838168 SGTC_2669 eugenol 100 µM -0.776667257000609 0.248255573403063 no 2536 0.218677554769699 839 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_3089 9117425 49.47 µM -0.777413854749305 0.248047371684107 no 2537 0.218457320466113 872 9401657 SGTC_1692 fluoroquinolonic acid 71 µM -0.778404647130002 0.247771215969571 no 2538 0.218165250011283 867 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_3264 9137442 49.47 µM -0.781651817868196 0.246867309562054 no 2539 0.217209612539887 856 17015726 SGTC_941 3237-0776 460 µM -0.782185878902458 0.246718813594236 no 2540 0.217052671051846 863 760008 SGTC_3001 9076041 71.4286 µM -0.782365615084217 0.246668848608212 no 2541 0.216999867740007 854 16004211 SGTC_523 1934-0222 13.7 µM -0.784785834836301 0.245996578125451 no 2542 0.216289573337232 892 1361595 SGTC_375 3970-0961 9.27 µM -0.785210651726403 0.245878677178744 no 2543 0.216165035625914 852 2898222 SGTC_1339 1486-1321 22.7 µM -0.785238339094467 0.245870994057588 no 2544 0.216156920343553 871 3469382 SGTC_2831 7999036 19.48 µM -0.785458713731318 0.245809845673347 no 2545 0.216092333914967 875 2988270 SGTC_694 1315-0438 43.2 µM -0.786289176253849 0.245579486706964 no 2546 0.215849046060456 845 6793154 SGTC_353 1988-1175 58.3 µM -0.787488976150827 0.245246883482824 no 2547 0.215497839583417 876 2788357 SGTC_14 0354-0009 295 µM -0.787659925865366 0.245199513278074 no 2548 0.215447826024119 883 1713507 SGTC_345 1362-0200 395 µM -0.788317057712143 0.245017467707294 no 2549 0.215255636266142 873 1419823 SGTC_3293 9120939 62.045 µM -0.78834924826614 0.245008551810228 no 2550 0.215246224129937 862 934087 SGTC_428 3448-4153 16.5 µM -0.788647107021028 0.24492606141695 no 2551 0.215159145093192 858 3834874 SGTC_1679 SEC14.276 6.7 µM -0.793190478440068 0.243669653529537 no 2552 0.213833427071055 858 1005053 YMR079W SEC14 SGTC_2786 7743617 45.45 µM -0.793371837626701 0.243619573429486 no 2553 0.213780606881804 862 583674 SGTC_449 xestospongin c 11.1929 µM -0.793436356229234 0.24360175875451 no 2554 0.21376181791116 868 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2918 7977171 22.06 µM -0.793844581098282 0.243489057288418 no 2555 0.2136429578268 843 2236483 SGTC_538 2922-0838 53.3 µM -0.795552184152244 0.243017932974034 no 2556 0.213146184119209 890 777039 SGTC_2766 oltipraz 83.91 µM -0.798063629355125 0.242325926997019 no 2557 0.212416783158729 846 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1987 st072290 61.9 µM -0.799458772289558 0.241941969848516 no 2558 0.212012221619916 862 54697379 SGTC_69 0096-0274 206.684 µM -0.799746076134815 0.2418629419834 no 2559 0.211928965653316 888 6741392 SGTC_2450 5739737 12.93 µM -0.802867353586231 0.241005284215248 no 2560 0.211025703583644 870 2262825 SGTC_1649 st011737 51.3 µM -0.803560948287407 0.240814924631504 no 2561 0.210825292082322 829 1761035 SGTC_1211 1056-0033 32.3 µM -0.803576166203832 0.240810748936451 no 2562 0.210820896176118 862 6741922 SGTC_2158 5657123 3.6195 µM -0.804065320581106 0.240676549216055 no 2563 0.210679625786751 892 2858827 SGTC_3017 9080681 49.47 µM -0.804858654733615 0.240458984213739 no 2564 0.210450624774622 880 16451914 SGTC_172 1112-0046 2.638 µM -0.806681038457933 0.239959617178019 no 2565 0.20992513561723 893 2802135 YIL048W NEO1 SGTC_1804 st050076 49.1 µM -0.807528067788697 0.239727708046849 no 2566 0.209681155215914 878 3895976 SGTC_1922 5578187 25 µM -0.808376523001724 0.239495531185806 no 2567 0.209436931347015 831 1350412 SGTC_2877 9040724 71.43 µM -0.809399259743235 0.239215826057484 no 2568 0.209142763934828 890 6463895 SGTC_2493 resveratrol 26.09 µM -0.810028880539889 0.23904372180768 no 2569 0.208961788599784 842 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2787 5284540 71.43 µM -0.810955116793745 0.238790662024628 no 2570 0.208695723197865 875 736958 SGTC_2757 clomiphene 4.22 µM -0.811083281898434 0.238755657197935 no 2571 0.208658922945281 878 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2226 7298446 200 µM -0.81393008286389 0.23797885477912 no 2572 0.207842502909591 874 3283010 SGTC_1306 1185-0270 9.02 µM -0.815324196326002 0.237598951057899 no 2573 0.207443381070074 885 1548076 SGTC_1044 1222-0021 1.78 µM -0.815756346542185 0.237481255311453 no 2574 0.207319752490148 855 4306703 SGTC_374 0880-0231 82.3 µM -0.815822248680605 0.237463309732438 no 2575 0.207300903180907 875 6833587 SGTC_1220 1838-0075 193 µM -0.816149497994746 0.237374208652413 no 2576 0.207207318444134 857 5529645 SGTC_1433 4060-0023 7.6 µM -0.818373142789686 0.236769257126344 no 2577 0.20657207627584 874 3840627 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.819234171166577 0.236535238804348 no 2578 0.206326411181264 875 5024745 SGTC_356 1634-0012 32.5 µM -0.819416657499817 0.236485657318555 no 2579 0.206274367172506 879 735457 SGTC_2377 9073351 62.6 µM -0.823985266700001 0.235246233395757 no 2580 0.20497396474682 907 7337946 YHR072W ERG7 SGTC_2126 5251174 33.877 µM -0.826625545354036 0.234531587336006 no 2581 0.204224666866184 878 790722 SGTC_885 0865-0106 16.8 µM -0.82721850754308 0.234371255146942 no 2582 0.204056611736565 871 2793380 SGTC_2046 4110841 106 µM -0.828405525254987 0.234050477466035 no 2583 0.203720439244612 882 44119630 YMR134W ERG29 SGTC_1721 st082152 9.2685 µM -0.829186957804458 0.233839437243286 no 2584 0.203499311914288 897 5296051 SGTC_1756 st041558 35.5 µM -0.829264962753015 0.233818376363431 no 2585 0.203477246180722 910 3955792 SGTC_1217 1183-1422 255 µM -0.830629380397766 0.233450161632855 no 2586 0.20309151593821 874 2849664 SGTC_1236 0330-0013 258 µM -0.831088989335254 0.233326199654781 no 2587 0.202961679698277 894 4617066 SGTC_545 4218-0007 221 µM -0.831495657358888 0.233216546932358 no 2588 0.202846840234367 889 2840508 SGTC_626 0214-0009 33 µM -0.831849894182685 0.233121054911988 no 2589 0.202746838518407 893 3437874 SGTC_559 1550-0661 158 µM -0.83468490199269 0.232357601226975 no 2590 0.20194757231813 887 5830875 SGTC_26 0302-0163 425.158 µM -0.834701451332093 0.232353148658131 no 2591 0.201942912151043 913 3100915 SGTC_653 0203-0016 55.2 µM -0.835229956762742 0.23221098022313 no 2592 0.201794122929985 888 295302 SGTC_918 glabranin 770.725 nM -0.835362472701429 0.23217534090874 no 2593 0.201756826242566 880 124049 Also referred to as licorice root. SGTC_2556 citropten 84.59 µM -0.835808368387831 0.232055442472979 no 2594 0.201631358962941 863 2775 A potential DNA crosslinker. SGTC_2908 7930301 100 µM -0.841422959628085 0.230548668743027 no 2595 0.200055513785705 860 2223178 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.841676303672308 0.230480808609138 no 2596 0.199984582826506 878 1273210 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.841844031084267 0.230435887686339 no 2597 0.199937631028996 866 17037758 SGTC_1221 2958-7315 257 µM -0.842045698326961 0.230381883444891 no 2598 0.199881187259389 887 4562705 SGTC_201 4262-0159 12.803 µM -0.842279696316422 0.230319230259216 no 2599 0.19981570658936 889 1341029 SGTC_2376 9072922 81.32 µM -0.84420487184607 0.229804124482451 no 2600 0.199277466311199 902 17087968 SGTC_2019 4016004 108 µM -0.845927626779923 0.229343726367782 no 2601 0.198796559773574 900 45595336 SGTC_45 0kpi-0036 14.9 µM -0.847317994856443 0.228972534425314 no 2602 0.198408949592588 878 2795021 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.847795114813387 0.228845233595098 no 2603 0.198276042099087 845 6708630 An antioxidant. SGTC_1973 st070275 50.2 µM -0.849392960447709 0.228419200290591 no 2604 0.19783133447619 861 17118334 SGTC_2893 9048488 25.97 µM -0.850365287598385 0.228160167133038 no 2605 0.197561014456368 913 6467338 SGTC_987 1497-1013 404 µM -0.850433319031712 0.228142049379451 no 2606 0.197542109165323 879 1676435 SGTC_529 4076-0302 30.3 µM -0.854460824626557 0.227070909023138 no 2607 0.196424853363071 899 5816522 SGTC_2861 9024595 19.48 µM -0.855915536163846 0.22668471751151 no 2608 0.196022250375064 854 16482810 SGTC_2075 5212009 200 µM -0.856036401000362 0.2266526474423 no 2609 0.195988822607964 874 780898 SGTC_2104 5389443 200 µM -0.856506892362373 0.226527832456545 no 2610 0.195858731049613 904 2244536 SGTC_1187 1391-0724 117 µM -0.857761613664302 0.226195161695233 no 2611 0.195512055044034 890 6997986 SGTC_2288 7946289 167.31 µM -0.861411026364912 0.22522914472123 no 2612 0.194505852636446 912 1246052 SGTC_1285 0929-0069 65.5 µM -0.861931071830276 0.225091676676003 no 2613 0.194362724654791 881 1206237 SGTC_2362 9071156 126 µM -0.862681609302873 0.224893364555556 no 2614 0.194156273276535 909 653133 SGTC_631 k072-0230 41.5 µM -0.863093662612725 0.224784531153259 no 2615 0.194042986022676 917 5773147 SGTC_3182 9108849 49.47 µM -0.863404841175026 0.224702361046532 no 2616 0.193957459311973 884 17133045 SGTC_3128 9127691 49.47 µM -0.866090958399785 0.223993770980699 no 2617 0.193220141557658 891 41316314 SGTC_2608 thymoquinone 42.66 µM -0.867038270400949 0.223744175912599 no 2618 0.192960520565865 900 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2829 7992743 58.44 µM -0.868491273943879 0.223361650093483 no 2619 0.192562723616717 902 16462845 SGTC_1388 3346-4487 254 µM -0.868909273889497 0.223251674062885 no 2620 0.192448378331955 914 3345614 SGTC_1271 0832-2808 169 µM -0.86973102666374 0.223035560305391 no 2621 0.192223706168886 893 3663794 SGTC_2262 9014885 67.46 µM -0.870104692321167 0.222937328939827 no 2622 0.192121596812772 894 6457424 SGTC_1261 0712-0010 12.7 µM -0.870313231605364 0.222882517656459 no 2623 0.192064624974262 900 2840123 SGTC_1468 k284-1086 134 µM -0.873166185348111 0.222133434834076 no 2624 0.191286251492052 891 15996457 SGTC_548 1436-0017 110 µM -0.873721801395284 0.221987717438843 no 2625 0.191134887610113 887 9677137 SGTC_53 0973-0023 39.979 µM -0.874215949545427 0.221858166651028 no 2626 0.191000330860798 910 674768 SGTC_3015 9080845 49.47 µM -0.875347091682399 0.221561777804189 no 2627 0.190692539165005 885 5296973 SGTC_505 gw-5074 63.9 µM -0.876173174524099 0.221345465543961 no 2628 0.190467948693771 905 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_3040 9091894 49.47 µM -0.878683952315087 0.220688752742952 no 2629 0.189786331074255 846 25236966 SGTC_2700 st077718 96.8 µM -0.879752907455035 0.220409498560981 no 2630 0.189496590521201 894 904970 SGTC_624 k048-0052 28 µM -0.88066004245969 0.22017267727215 no 2631 0.189250924979001 894 6835531 SGTC_81 0411-0046 9.971 µM -0.881591439521969 0.219929673914998 no 2632 0.188998893032969 883 12925265 SGTC_1757 st041620 31.8375 µM -0.88199875556857 0.219823452732152 no 2633 0.188888740113255 928 5289815 SGTC_1971 st069429 63.5 µM -0.88344478619802 0.219446590161749 no 2634 0.18849800097574 885 1246522 YGL099W LSG1 SGTC_1644 st010134 20.9 µM -0.883766658410751 0.219362754791215 no 2635 0.18841109415302 895 3818134 SGTC_2551 apiole 73.87 µM -0.884580139092964 0.219150956317691 no 2636 0.188191561201709 876 10659 A possible DNA adduct former. SGTC_1120 ficusin 1.78878 µM -0.884819128088611 0.219088755305145 no 2637 0.188127095569167 917 6199 A DNA cross-linker. SGTC_564 3555-0129 330 µM -0.885766903916752 0.218842180262247 no 2638 0.187871573801415 875 563260 SGTC_532 1548-0774 215 µM -0.886094752817199 0.218756923692802 no 2639 0.187783235163942 930 5932993 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.887151776167567 0.218482176696668 no 2640 0.18749859576079 898 676296 Flavone; oxidizing agent. SGTC_1129 3453-1384 223 µM -0.890276613935634 0.217671115664742 no 2641 0.186658687588096 922 1084452 SGTC_281 1672-3440 14.9 µM -0.890370601618447 0.217646747821582 no 2642 0.186633461287033 894 6833000 SGTC_351 caspofungin 25 nM -0.890778505412033 0.217541010336973 no 2643 0.186524004339991 873 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2827 7993847 71.43 µM -0.891290096704747 0.217408436731738 no 2644 0.186386780089632 860 2985692 SGTC_85 0868-0259 160.055 µM -0.891874393955093 0.217257079204602 no 2645 0.186230130427989 863 83173 SGTC_3252 9135871 49.47 µM -0.894022248345433 0.216701218042015 no 2646 0.185654993734375 912 17682838 SGTC_2200 6600604 21.907 µM -0.89420951665632 0.216652792327368 no 2647 0.185604900684827 926 2904777 SGTC_1175 0741-0056 27.6 µM -0.899091555480094 0.215392556160258 no 2648 0.184301947844177 906 765927 SGTC_1358 1509-0022 2.48 µM -0.899363254174357 0.215322545755391 no 2649 0.184229602564069 907 3258434 SGTC_3014 9081533 49.47 µM -0.900728470974614 0.214970961209977 no 2650 0.183866353510238 908 21367265 SGTC_895 0964-0006 13.7 µM -0.900929112449309 0.214919318086318 no 2651 0.183813005599377 912 6738897 SGTC_2516 gossypol 71.55 µM -0.901936038398055 0.214660254190138 no 2652 0.183545422955318 917 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_712 r015-0009 80.6 µM -0.902311509226897 0.214563698788 no 2653 0.18344570671096 922 6813872 YLR060W FRS1 SGTC_2976 9009005 19.48 µM -0.903431415797687 0.214275855629182 no 2654 0.183148486427183 851 2993148 SGTC_1423 4048-0112 5.59 µM -0.905458901757883 0.213755314387346 no 2655 0.182611161615949 897 X1423 SGTC_1390 3413-2614 145 µM -0.905560373739769 0.213729281613145 no 2656 0.182584295379853 931 3421432 SGTC_1324 1418-0026 34.4 µM -0.908791289353068 0.212901351802853 no 2657 0.181730152708098 926 1372513 SGTC_1401 3807-4679 7.6 µM -0.912146836857173 0.212043469438973 no 2658 0.180845712726376 899 3291456 SGTC_2180 6301957 200 µM -0.913292104483236 0.211751132624919 no 2659 0.180544466889615 902 845462 SGTC_3021 9087658 49.47 µM -0.913628588020068 0.211665287918991 no 2660 0.180456019687554 891 25237042 SGTC_2796 7949634 45.45 µM -0.913939759527977 0.211585919027117 no 2661 0.180374250136275 911 2971588 SGTC_1370 2001-0092 44.6 µM -0.914595570222839 0.211418701882868 no 2662 0.180201992549385 894 790957 SGTC_2932 9016711 44.54 µM -0.914704924884898 0.211390826406348 no 2663 0.180173279109279 921 7117328 SGTC_697 0508-1955 564 µM -0.915845950078284 0.211100097365827 no 2664 0.179873849511381 895 6243113 SGTC_1389 3405-0187 19 µM -0.916301807921102 0.21098401200305 no 2665 0.17975431001837 892 799890 SGTC_1759 st043059 70 µM -0.918532636639824 0.210416465715343 no 2666 0.179170040329492 926 669426 SGTC_3142 9086498 49.47 µM -0.919620286030483 0.210140081583165 no 2667 0.178885611002196 876 25236367 SGTC_2065 5221596 34.26 µM -0.920526354271588 0.209910002198874 no 2668 0.178648883753544 902 788581 SGTC_442 cape 100 µM -0.92078877581828 0.209843392728356 no 2669 0.178580358080916 909 5281787 SGTC_377 3970-0964 33.1 µM -0.921470947888105 0.20967029770691 no 2670 0.178402301159844 889 16481235 SGTC_1280 0880-0253 10.1 µM -0.923290018646884 0.209209135546613 no 2671 0.177928044028476 918 6836607 SGTC_10 0279-0212 42.575 µM -0.924981347603767 0.208780894046249 no 2672 0.177487804952915 914 39851 YBR002C RER2 SGTC_349 k015-0014 24 µM -0.925019822672785 0.208771158239726 no 2673 0.177477798212583 917 2196908 SGTC_1021 4476-0760 85.3 µM -0.930908058394257 0.207284343427107 no 2674 0.175950562857331 926 746768 SGTC_3190 9110366 49.47 µM -0.932561475884003 0.206867974270647 no 2675 0.175523215893716 902 17123768 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.933037562021339 0.206748176512211 no 2676 0.1754002874051 926 5377381 SGTC_581 0958-0271 211 µM -0.935374139628013 0.20616081824325 no 2677 0.17479775965142 899 4591145 SGTC_763 3453-1109 128 µM -0.938451989807998 0.205388633957083 no 2678 0.174006089355675 905 1560353 SGTC_562 3772-2733 112 µM -0.93851583809758 0.205372633631671 no 2679 0.173989690767693 916 2876874 YIL048W NEO1 SGTC_151 3013-0144 2.285 µM -0.938941496358058 0.205265982965786 no 2680 0.173880391190217 911 906558 YHR107C CDC12 SGTC_3081 9117243 49.47 µM -0.940466196531013 0.204884232315581 no 2681 0.173489240509758 915 45595589 SGTC_1873 rapamycin 2 nM -0.945280726962778 0.203681556421896 no 2682 0.172257787604961 894 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_426 0988-0037 14.6 µM -0.946048576292265 0.203490136619994 no 2683 0.172061905264371 923 5383008 SGTC_355 1311-2252 105 µM -0.946219974183615 0.203447422904452 no 2684 0.172018200193358 931 5338538 SGTC_916 4466-0038 42 nM -0.946721097271481 0.203322569735537 no 2685 0.171890458528212 927 5722064 YGL116W CDC20 SGTC_2847 9005661 71.43 µM -0.947488051879511 0.203131574079117 no 2686 0.171695070876027 892 2991449 SGTC_3123 9126162 49.47 µM -0.947536476964006 0.203119518316335 no 2687 0.171682738972644 894 25239884 SGTC_685 1278-0033 54.9 µM -0.949999488685794 0.202506897911405 no 2688 0.171056256212518 921 3590572 SGTC_1413 3910-0535 34.4 µM -0.955052202727225 0.201253608146869 no 2689 0.169775649246564 907 2876951 SGTC_640 3381-0960 37.1 µM -0.956814563313249 0.2008175633635 no 2690 0.169330430124242 920 1745025 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.960016613733283 0.200026761664675 no 2691 0.168523426748212 927 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_795 0685-0265 78 µM -0.967746868205785 0.198125373050535 no 2692 0.166585402419184 910 302754 SGTC_546 peri-Naphthalide 147 µM -0.968249567411971 0.198002104623741 no 2693 0.166459872618895 894 223824 A penicillin ester. SGTC_768 0384-0033 77.3 µM -0.969199883448172 0.197769201272595 no 2694 0.166222734614995 903 3965305 YMR134W ERG29 SGTC_2418 pentamidine 31.67 µM -0.969634020637504 0.197662858086008 no 2695 0.166114474430942 882 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2640 pentamidine 10.38 µM -0.970115241152846 0.197545022094694 no 2696 0.165994526386829 888 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1637 st007924 17.4 µM -0.971765551307378 0.197141234948958 no 2697 0.16558359865854 891 683336 SGTC_2996 9066192 71.4286 µM -0.972894473865141 0.19686530541392 no 2698 0.165302875886676 905 6472854 SGTC_1122 capsaicin 818.572 nM -0.973372493447804 0.196748539098279 no 2699 0.165184102332126 914 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_806 3966-4455 5.86 µM -0.979113881740756 0.195349364178974 no 2700 0.163761856682824 923 714982 SGTC_2219 9098279 200 µM -0.979460191525645 0.195265162320312 no 2701 0.16367632442211 898 902349 SGTC_2755 lomerizine 42.69 µM -0.979674932559017 0.195212961203738 no 2702 0.163623301836381 909 3949 A calcium channel blocker. SGTC_3024 9090631 49.47 µM -0.980106148064413 0.195108163207236 no 2703 0.163516862340635 894 25236383 SGTC_1790 st045711 43.5 µM -0.980125879583012 0.195103368688678 no 2704 0.163511992968262 866 585119 SGTC_301 4119-0100 24.5 µM -0.981816036551717 0.194692946980644 no 2705 0.163095243128758 937 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_949 1165-0505 146 µM -0.983107146413065 0.194379780254083 no 2706 0.162777353717135 927 6244267 SGTC_1345 1488-0192 31.4 µM -0.983949565820009 0.194175611616576 no 2707 0.16257015559435 928 658348 SGTC_317 4495-0002 170 µM -0.984105340957207 0.194137872293134 no 2708 0.162531860569379 916 15991618 SGTC_553 k007-0256 45.7 µM -0.984647487142639 0.194006562485111 no 2709 0.162398627674784 926 6287000 SGTC_2957 9076800 11.52 µM -0.987169967258407 0.193396320447034 no 2710 0.161779661070818 953 16459615 SGTC_3183 9108214 49.47 µM -0.988470567079196 0.193082135567809 no 2711 0.161461121132362 920 4974831 SGTC_1114 scopoletin 1.73284 µM -0.988864289374207 0.19298708586463 no 2712 0.161364772263913 940 5280460 A coumarin with genotoxic properties. SGTC_283 0987-0079 11.7 µM -0.98902880654219 0.19294737773786 no 2713 0.161324523923992 914 411556 SGTC_1408 3909-7976 48.8 µM -0.99083368761315 0.19251207647802 no 2714 0.160883398383595 926 24152374 SGTC_73 0327-0325 16.231 µM -0.991282113191301 0.192404018366141 no 2715 0.160773922277267 870 53298 SGTC_938 3126-1755 342 µM -0.992368048058998 0.192142491914615 no 2716 0.160509009800544 911 1777771 SGTC_1745 st081495 74 µM -0.992581498782592 0.192091112015587 no 2717 0.160456972312539 904 13842402 YBL026W LSM2 SGTC_1451 4152-0210 104 µM -0.99373884844102 0.191812671821457 no 2718 0.160175012149932 948 659563 SGTC_1515 3460-0031 42.1 µM -0.994351323999224 0.191665419837892 no 2719 0.16002592848074 915 2876596 SGTC_404 fumagillin 50 µM -0.9946480243355 0.191594111747091 no 2720 0.15995374080563 919 12015870 A methionine aminopeptidase binder. SGTC_3036 9090181 49.47 µM -0.994698291625862 0.19158203226361 no 2721 0.159941512802063 933 25236586 SGTC_3327 9140648 26.9345 µM -0.994816865010518 0.191553540329212 no 2722 0.15991267110382 930 8029710 SGTC_430 0958-0115 16.4 µM -0.996725858956331 0.191095186584624 no 2723 0.159448797172685 927 6833180 SGTC_2722 naftopidil 47.16 µM -0.997802805922715 0.190836906175119 no 2724 0.15918749465019 934 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_990 3985-0011 41.3 µM -0.998129511516161 0.190758595882608 no 2725 0.159108280679623 928 5399565 YGL099W LSG1 SGTC_3230 9131665 49.47 µM -0.998236528224393 0.190732948606019 no 2726 0.159082338718711 909 15943720 SGTC_3064 1327-0027 10 µM -0.998691069970692 0.190624038192049 no 2727 0.158972183962892 892 16000455 YPR107C YTH1 SGTC_810 3825-7150 143 µM -0.99894788202344 0.190562521654978 no 2728 0.158909969605518 894 22330411 YGL099W LSG1 SGTC_2322 7413319 38.22 µM -1.00022660862685 0.19025639805148 no 2729 0.158600427490612 901 1840400 SGTC_2004 4023728 41.89 µM -1.00244726174155 0.189725498215958 no 2730 0.15806381282627 934 360084 YDR527W RBA50 SGTC_751 0833-0568 350 µM -1.00281470287138 0.189637740628946 no 2731 0.157975136749953 933 6954252 SGTC_203 k066-0004 30.888 µM -1.00305721807204 0.189579833334518 no 2732 0.157916627457442 964 6795412 SGTC_264 promethazine 12.5 mM -1.00454035148942 0.189225930457754 no 2733 0.157559115871465 936 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2076 5212012 200 µM -1.01004189797718 0.187916716956756 no 2734 0.156237608527191 930 604802 SGTC_1874 staurosporine 7.6 µM -1.01142397954383 0.187588701450634 no 2735 0.155906774455704 914 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1371 2421-0008 32.7 µM -1.01205859550298 0.187438203840044 no 2736 0.155755018863917 922 2827552 SGTC_1555 citronellol 128 µM -1.01274805378746 0.187274785113161 no 2737 0.155590259268215 929 8842 A terpine precursor. SGTC_3306 9127676 59.7925 µM -1.01290703695785 0.187237114658125 no 2738 0.155552283434654 919 41905287 SGTC_4 0960-0234 25.671 µM -1.0142051164343 0.186929715019599 no 2739 0.155242443868887 908 6821112 SGTC_2763 lisinopril 49.32 µM -1.01718462179486 0.186225316917706 no 2740 0.154532805128451 926 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2843 9000894 45.46 µM -1.01751980892545 0.186146176899107 no 2741 0.1544531068746 889 2242070 SGTC_3224 9130643 49.47 µM -1.01819719272673 0.185986305501839 no 2742 0.154292126649711 945 17644395 SGTC_3253 9135987 49.47 µM -1.01828928140283 0.185964577950411 no 2743 0.154270250350885 933 4182430 SGTC_1266 0828-0227 32.9 µM -1.01853330000014 0.185907011418221 no 2744 0.154212291973061 947 3913820 SGTC_2837 9008476 45.46 µM -1.01881844649259 0.185839756389474 no 2745 0.15414458330173 923 2992805 SGTC_533 1222-0222 6.71 µM -1.01914274332256 0.185763285652848 no 2746 0.154067602198523 949 3982874 SGTC_2744 captopril 92.04 µM -1.02037089831027 0.185473857831763 no 2747 0.153776295169145 917 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_759 3486-0358 89.3 µM -1.02063970914266 0.185410547047011 no 2748 0.153712584385491 952 875103 SGTC_3277 9138724 49.47 µM -1.02066752356921 0.185403996911895 no 2749 0.153705993093443 920 15943418 SGTC_1924 st058459 75.1 µM -1.02216524876878 0.185051503515899 no 2750 0.153351347679537 928 688683 SGTC_1820 st053765 18.6 µM -1.02551595152714 0.18426441606696 no 2751 0.152559901338074 939 3690829 SGTC_280 3448-3607 3.04 µM -1.02677493694471 0.183969216858433 no 2752 0.152263226806285 916 626179 SGTC_655 k060-0012 42 µM -1.02775312769623 0.183740060072623 no 2753 0.152032984912948 955 5994525 SGTC_2451 5856223 45.7 µM -1.02853151208166 0.18355783822492 no 2754 0.151849937789642 927 2179896 SGTC_2541 muurolladie-3-one 83.07 µM -1.03020630358188 0.183166147126868 no 2755 0.151456585642805 921 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.03209386777909 0.182725319316813 no 2756 0.151014073140035 941 368090 SGTC_2273 7815444 169.05 µM -1.03426833379065 0.182218309334274 no 2757 0.150505368136334 950 2824616 SGTC_1552 6-methylflavone 10.6 µM -1.03459930163912 0.182141216292565 no 2758 0.150428040142016 933 689013 SGTC_3188 9110789 49.47 µM -1.03648922423595 0.181701383337291 no 2759 0.14998698201658 955 849217 SGTC_1242 0402-0103 60.1 µM -1.03721441106537 0.181532790520975 no 2760 0.149817971669232 938 432868 SGTC_1956 st077085 54 µM -1.03833729868848 0.181271932711994 no 2761 0.149556524825179 941 24208685 SGTC_3095 9117207 49.47 µM -1.03887968172992 0.181146015932089 no 2762 0.14943034852457 932 17015229 SGTC_2017 5132927 60.65 µM -1.03934911197768 0.181037079729125 no 2763 0.149321200845054 948 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_660 4031-1742 102 µM -1.04010750198387 0.180861174132022 no 2764 0.149144979338103 897 6738706 SGTC_224 benfluorex 43.875 µM -1.04523200692378 0.179675374532765 no 2765 0.147957876941429 954 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1362 1611-0397 101 µM -1.04526964340777 0.179666683640405 no 2766 0.147949181832098 949 27816 SGTC_3324 9138759 60.749 µM -1.04728445483754 0.17920181566837 no 2767 0.147484201765185 945 45595710 SGTC_2532 xanthone 78.9 µM -1.04909828720612 0.178783966354554 no 2768 0.147066442175921 950 7020 An insecticide. SGTC_2220 6782180 200 µM -1.05096592934943 0.178354362443664 no 2769 0.146637119070118 924 833803 SGTC_287 k060-0039 29.6 µM -1.05671920469433 0.177035059119751 no 2770 0.145319878779529 944 5861974 SGTC_678 1218-2179 85.9 µM -1.0609712090932 0.176063990347329 no 2771 0.144351492800969 960 6820081 YOR116C RPO31 SGTC_513 4245-1575 41.7 µM -1.06226538699046 0.175769097863915 no 2772 0.144057611568517 919 719745 SGTC_2785 7756463 72.73 µM -1.06295846028792 0.175611302311691 no 2773 0.143900394857083 944 2201551 SGTC_1948 st076329 66.6 µM -1.06302447546423 0.1755962769817 no 2774 0.143885426017247 939 24208413 SGTC_843 0310-0051 143 µM -1.06393036272954 0.175390175552097 no 2775 0.143680123573368 941 2065037 SGTC_666 0272-0154 136 µM -1.06672978178518 0.174754240120845 no 2776 0.14304693731624 957 6870312 SGTC_2851 9015922 71.43 µM -1.06716157109377 0.174656282325665 no 2777 0.142949441186005 917 2996893 SGTC_1529 apigenin 74 µM -1.06768843743476 0.174536802132605 no 2778 0.142830537917541 949 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1430 4049-0248 69.1 µM -1.06848900959509 0.174355351650179 no 2779 0.142649992677745 951 22774488 SGTC_2889 9059656 51.95 µM -1.06877755849477 0.174289981145934 no 2780 0.142584956903776 957 3949838 SGTC_63 0099-0242 26.702 µM -1.06907947108271 0.17422159978383 no 2781 0.142516930568473 939 3898502 YLR359W ADE13 SGTC_2849 9019321 12.99 µM -1.06960223240587 0.17410323785362 no 2782 0.142399194955968 940 16489627 SGTC_1294 1000-1494 117 µM -1.0696985414652 0.174081437444648 no 2783 0.142377511536685 939 712797 YDL207W GLE1 SGTC_173 1273-0061 2.693 µM -1.07206639024394 0.173545999745715 no 2784 0.14184510678746 916 2847414 YPL266W DIM1 SGTC_3238 9133470 49.47 µM -1.07567686448613 0.172731588951199 no 2785 0.141035898921667 913 3534688 SGTC_2958 9077254 16.72 µM -1.07791195212912 0.172228645548462 no 2786 0.140536525517301 952 16457351 SGTC_2915 7971052 15.16 µM -1.07873017679597 0.172044761069616 no 2787 0.140354014550176 913 5741558 SGTC_790 1575-0012 79.1 µM -1.07971669771867 0.171823221082735 no 2788 0.140134177982965 932 378741 YLR208W SEC13 SGTC_935 2996-0153 430 µM -1.08379729339777 0.170908790599636 no 2789 0.139227342776637 948 23738523 SGTC_2161 5662504 8.5105 µM -1.08469470505025 0.170708105914546 no 2790 0.139028446899476 908 2859334 SGTC_2624 nerol 100 µM -1.0850826482303 0.170621398401518 no 2791 0.138942525868213 949 637566 A natural product oil. SGTC_56 0957-0365 83.25 µM -1.08648739111488 0.170307666294226 no 2792 0.138631708191501 945 6752360 SGTC_3340 9146634 11.102 µM -1.08678737798044 0.17024071582036 no 2793 0.138565393613196 933 4907387 SGTC_1972 st070201 17.4 µM -1.08690007562836 0.170215568540657 no 2794 0.138540486451655 948 2829099 SGTC_1012 4112-3522 18 µM -1.08724926369774 0.170137666055386 no 2795 0.138463332217701 942 3112398 SGTC_171 k064-0041 9.68 µM -1.0876450442381 0.170049396601561 no 2796 0.138375918635069 928 53325 SGTC_1096 rimcazole 32.2 µM -1.08880152188581 0.169791639941172 no 2797 0.138120710182031 932 18528119 A dopamine reuptake inhibitor. SGTC_1660 st012960 28.1 µM -1.08913993538668 0.169716261479988 no 2798 0.13804609071936 945 24207266 SGTC_3354 9151612 71.43 µM -1.08926367078571 0.169688705929457 no 2799 0.138018814190332 938 27261949 SGTC_438 sphingosine 6.67 µM -1.09481457987228 0.1684554855317 no 2800 0.136798938815069 954 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2390 9097792 176.6 µM -1.09612659681316 0.168164844810951 no 2801 0.13651168837238 935 4497149 SGTC_1121 fusaric acid 630.51 nM -1.09757298586198 0.167844811815623 no 2802 0.136195497148195 949 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2986 9022445 71.43 µM -1.09839109430061 0.167663968071832 no 2803 0.136016874747261 921 6459286 SGTC_3335 9143315 29.6265 µM -1.09877923443966 0.167578213188067 no 2804 0.135932185957218 928 4899691 SGTC_29 0299-0004 12.984 µM -1.10126036344592 0.167030705343357 no 2805 0.135391678344445 961 16871 A napthoquinone isolated from Swertia calycina. SGTC_3195 9113082 49.47 µM -1.10279740288436 0.166692107950594 no 2806 0.135057578106751 951 17018038 SGTC_3058 9093861 49.47 µM -1.10374879378883 0.166482746294423 no 2807 0.134851061519667 939 17217477 SGTC_2388 9080168 200 µM -1.10437992694955 0.166343953776743 no 2808 0.13471418225109 949 15943073 SGTC_1952 st077036 64.1 µM -1.10490477757093 0.166228590777148 no 2809 0.13460042602428 946 2937007 SGTC_595 3909-8003 73.7 µM -1.10498288710263 0.166211426596721 no 2810 0.134583502186886 965 699517 SGTC_18 0111-0177 500 nM -1.10626092232324 0.16593074733821 no 2811 0.134306800280205 960 721752 SGTC_872 0588-0139 234 µM -1.10798188170566 0.165553278317995 no 2812 0.133934820391557 943 2047100 SGTC_2461 5755302 26.15 µM -1.10879538242366 0.165375041472024 no 2813 0.133759231467827 988 2788904 SGTC_2449 5812982 45.77 µM -1.10964894659444 0.165188160309169 no 2814 0.133575165301322 965 776185 SGTC_2177 5811945 192 µM -1.11171678996661 0.164735989182692 no 2815 0.133129969234188 937 5343475 SGTC_1486 3970-0793 4.53 µM -1.11252630495712 0.164559192779764 no 2816 0.132955963266395 967 2844330 SGTC_944 3370-0224 231 µM -1.11513630736422 0.163990011317364 no 2817 0.13239600745725 959 4580514 SGTC_3056 9094900 49.47 µM -1.11946793915345 0.163048204565878 no 2818 0.131470280572484 959 25236784 SGTC_1447 4239-0816 81.9 µM -1.12004505238541 0.162922991434764 no 2819 0.131347282011594 944 1341554 SGTC_3257 9139206 32.98 µM -1.12249970565583 0.162391117287677 no 2820 0.130825016316087 954 4910041 SGTC_1035 k081-0041 55.2 µM -1.12468221846019 0.161919160732632 no 2821 0.130361859659321 943 731709 SGTC_1086 cerivastatin 2.18 µM -1.12669123006311 0.161485513529996 no 2822 0.129936525825723 917 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1889 st059080 5.18 µM -1.12691190987475 0.161437925769239 no 2823 0.129889863672476 960 176925 Isolated from Daphnopsis sellowiana. SGTC_1571 st070080 73.4 µM -1.1270416543824 0.161409951717456 no 2824 0.129862434961128 938 4315245 SGTC_932 2857-0803 154 µM -1.12908563113804 0.160969669632444 no 2825 0.129430856079208 954 674898 SGTC_737 1950-0117 57.9 µM -1.1307796760171 0.160605359119314 no 2826 0.12907391812573 951 5393513 SGTC_2811 7967822 32.47 µM -1.13262184698829 0.160209805273952 no 2827 0.128686545057048 949 2232244 SGTC_2588 indole-3-carbinol 100 µM -1.13342524950321 0.160037497017473 no 2828 0.128517857851326 963 3712 Induces cell cycle arrest. SGTC_313 3474-0040 5.03 µM -1.13390597477486 0.159934452331273 no 2829 0.128416995315781 957 1043375 YIL048W NEO1 SGTC_2627 acetyl isogambogic acid 100 µM -1.13641280115855 0.159397811017197 no 2830 0.12789192039038 977 6857789 A caspase activator and apoptosis inducer. SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.13767171095097 0.159128758889707 no 2831 0.127628795096479 977 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_3189 9110682 49.47 µM -1.13857143505319 0.15893665372604 no 2832 0.127440974115087 990 17122418 SGTC_1621 st003705 32.4 µM -1.14098721761395 0.158421598555726 no 2833 0.126937621152713 960 24207032 SGTC_1863 st057641 20.1 µM -1.14821934199081 0.156886231247201 no 2834 0.125439013224067 986 3921635 SGTC_1867 st057372 64 µM -1.14904503460419 0.156711562947163 no 2835 0.12526870564526 960 688837 SGTC_1183 1254-0324 198 µM -1.15095639288137 0.156307722499945 no 2836 0.124875087957231 951 5799357 SGTC_2684 capsaicin 100 µM -1.15140867928986 0.156212261761565 no 2837 0.124782072426143 959 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3157 9099274 49.47 µM -1.15163528658671 0.15616444788572 no 2838 0.12473548742719 947 17217662 SGTC_2748 diazoxide 86.69 µM -1.15275144822025 0.155929079812542 no 2839 0.124506208870011 906 3019 A potassium channel activatior. SGTC_3237 9133362 49.47 µM -1.15370065085926 0.155729102924938 no 2840 0.124311458492475 974 43845137 SGTC_986 1493-0483 84 µM -1.15492917519057 0.155470530083558 no 2841 0.124059715416925 969 40079 SGTC_215 1287-0124 461.5 µM -1.15744675784577 0.15494152906663 no 2842 0.123544940008664 981 5560863 SGTC_1658 st012944 20 µM -1.1599743614519 0.154411619702762 no 2843 0.123029622403787 963 24207260 SGTC_367 0335-0881 7.1 µM -1.16105705229125 0.154185001709739 no 2844 0.122809349363259 979 23828853 SGTC_846 0335-0850 148 µM -1.16122411477123 0.154150053466835 no 2845 0.122775385211312 949 6819598 SGTC_1596 piperlongumine 63 µM -1.16191912882261 0.154004717882485 no 2846 0.122634158113045 955 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3150 9097574 49.47 µM -1.16255932391699 0.15387092582868 no 2847 0.122504171115314 949 17217476 SGTC_39 0986-0283 58.349 µM -1.16387132671578 0.153596975550749 no 2848 0.12223808056959 942 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2006 4011487 200 µM -1.16761011649164 0.152818077129594 no 2849 0.121482033822111 962 45595294 SGTC_2078 5212016 200 µM -1.16910473786945 0.152507438270467 no 2850 0.12118071763868 966 1899708 SGTC_904 1141-0088 396 µM -1.16955985409173 0.152412931182507 no 2851 0.121089070543353 993 1378119 SGTC_83 0170-0301 39.027 µM -1.17057268239594 0.152202752007397 no 2852 0.120885291569693 987 3089716 SGTC_897 1000-0139 31.4 µM -1.17246251861929 0.151811093478384 no 2853 0.120505705932984 974 6151020 SGTC_2012 4023501 200 µM -1.1725745871296 0.151787888926586 no 2854 0.120483222651854 980 3477460 SGTC_1691 st019933 84.6 µM -1.17388041466259 0.151517682133317 no 2855 0.120221464144045 992 6176082 SGTC_1000 4048-0884 8.67 µM -1.17651051859674 0.150974422303233 no 2856 0.119695465819572 980 13040088 SGTC_3155 9099265 49.47 µM -1.17769846989326 0.150729471123733 no 2857 0.119458418567482 975 25236499 SGTC_1262 0737-0114 49.6 µM -1.17879352840386 0.150503908616025 no 2858 0.119240200964426 972 765919 SGTC_2666 tannic acid 100 µM -1.18065689826338 0.150120604769749 no 2859 0.118869525243101 948 16134267 A thiamine antagonist. SGTC_2217 6934799 96.0675 µM -1.18220335810725 0.14980298536483 no 2860 0.118562510257842 972 675606 SGTC_84 0443-0269 128.823 µM -1.18516035304868 0.149196912258688 no 2861 0.117977026141411 931 6150058 SGTC_597 k018-0003 82.8 µM -1.18613291576357 0.148997931717497 no 2862 0.11778490673758 983 6786234 SGTC_2910 7948405 25.97 µM -1.18682322902563 0.148856805358504 no 2863 0.117648677114866 921 2971328 SGTC_1755 st041960 45.185 µM -1.18781252001188 0.148654712328877 no 2864 0.117453640340559 974 2257073 SGTC_2586 curcumin 80 µM -1.19080562432263 0.148044396326984 no 2865 0.116864950213142 985 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1252 0493-0875 34.8 µM -1.1927035540213 0.147658264542423 no 2866 0.116492746631053 956 3960963 SGTC_1302 1159-0335 255 µM -1.19475499112269 0.147241661066012 no 2867 0.116091385095992 973 649284 SGTC_3073 9114972 49.47 µM -1.19678976490171 0.146829220583497 no 2868 0.1156942543039 957 41905075 SGTC_2261 9010538 184.68 µM -1.19811221091019 0.146561581999353 no 2869 0.115436667851367 992 6457250 SGTC_2820 7989630 71.43 µM -1.19919401883256 0.146342887733771 no 2870 0.115226256219068 942 2984098 SGTC_929 2805-0021 398 µM -1.20074068783215 0.146030599635127 no 2871 0.11492590288825 1013 3098024 SGTC_1829 berberine 14.4 µM -1.20592893903641 0.144986311125368 no 2872 0.113922445607395 930 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2346 9031566 143.75 µM -1.20978704517585 0.144213020432283 no 2873 0.113180309253621 982 4771086 SGTC_1622 st003707 19.4 µM -1.21095208717918 0.143980055491177 no 2874 0.112956884056522 953 10140899 SGTC_755 1995-0008 37.3 µM -1.21141715641675 0.143887129915793 no 2875 0.112867783670273 965 689533 SGTC_2706 st078239 82.5 µM -1.21289754071054 0.143591603443763 no 2876 0.112584498011973 979 15434492 SGTC_1466 k213-0079 57.5 µM -1.2138306549751 0.1434055381517 no 2877 0.112406198831172 1001 3657981 SGTC_2010 4012422 159 µM -1.21419347814177 0.143333234289077 no 2878 0.112336925195793 970 952393 SGTC_3318 9139014 38.6185 µM -1.21464629204822 0.143243031496005 no 2879 0.112250512476352 976 16643984 SGTC_360 0957-0399 1.01 µM -1.21790574922938 0.142594862715603 no 2880 0.11162989559616 984 6752301 YPR165W RHO1 SGTC_101 0490-5701 117.494 µM -1.21840200749247 0.142496352086387 no 2881 0.111535621305496 954 4661669 SGTC_1029 k015-0030 64.7 µM -1.22282622317295 0.141620149778544 no 2882 0.110697669362607 969 2208316 SGTC_1803 st050068 52.4 µM -1.22393454842338 0.141401222298714 no 2883 0.110488459666507 974 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2840 9008771 71.43 µM -1.22836736157979 0.140527902806579 no 2884 0.109654547165263 954 2992978 SGTC_1742 st038235 28.8875 µM -1.22894400773591 0.14041456603991 no 2885 0.109546400003459 982 564103 YBR002C RER2 SGTC_2671 danthron 100 µM -1.23033389509566 0.140141646131299 no 2886 0.109286048274816 986 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_832 4083-0019 164 µM -1.23073669450491 0.140062619364471 no 2887 0.109210679609549 991 1990758 SGTC_2088 5278280 127.392 µM -1.23186278082156 0.139841848824476 no 2888 0.109000173340242 978 791502 SGTC_811 0416-0114 265 µM -1.23192909520612 0.139828855190592 no 2889 0.10898778588234 961 6612453 SGTC_2930 9013230 14.89 µM -1.23313595335155 0.139592526893987 no 2890 0.108762522799952 941 2995857 SGTC_544 k015-0020 52.4 µM -1.2338660407441 0.139449692308494 no 2891 0.108626412802133 980 3008304 SGTC_3069 9117009 49.47 µM -1.23527271440009 0.139174770501154 no 2892 0.108364512521496 973 41904981 SGTC_1646 st011709 75.6 µM -1.23645005777725 0.138944952996113 no 2893 0.108145659445577 987 5757843 SGTC_2321 7390090 138.78 µM -1.24011296934111 0.138231605508052 no 2894 0.107466806295099 1000 649046 SGTC_332 4112-0506 40.9 µM -1.24092196184107 0.138074392445828 no 2895 0.107317289409063 990 2790355 SGTC_921 1561-0023 372 µM -1.24170865622859 0.137921629601514 no 2896 0.107172037508615 972 24050882 SGTC_2458 5808907 16.39 µM -1.2421565085606 0.137834715715376 no 2897 0.107089411313387 982 2731747 SGTC_1070 indatraline 8.81 µM -1.24404720455895 0.137468203717757 no 2898 0.106741095099257 983 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_504 lovastatin 124 µM -1.24938089574221 0.136437854542008 no 2899 0.105762896252101 990 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_113 0099-0221 2.5 µM -1.25309658364051 0.135723196809225 no 2900 0.105085279606814 971 89219 SGTC_1276 0871-0068 94.2 µM -1.2535076223808 0.135644297369231 no 2901 0.105010513410734 980 3414906 SGTC_1761 st044296 37 µM -1.25444013059769 0.135465417677827 no 2902 0.104841036921734 994 1826700 SGTC_1855 st056195 39.6 µM -1.25677011632898 0.135019171711165 no 2903 0.104418445034889 946 4028379 SGTC_1049 3226-0134 66 µM -1.25955875743661 0.134486409421279 no 2904 0.10391429068118 982 5702385 SGTC_270 tamoxifen 5.46 µM -1.26163155361346 0.134091343586842 no 2905 0.103540698310894 1024 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_828 2074-0507 139 µM -1.26280710896528 0.133867642567368 no 2906 0.103329254639148 981 X828 SGTC_3055 9094636 49.47 µM -1.26416018447676 0.133610478225989 no 2907 0.103086269208212 986 25236176 SGTC_2742 clothiapine 36.27 µM -1.2668891301514 0.133092851203118 no 2908 0.102597467971408 983 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1791 st048313 56.1 µM -1.27089910931408 0.132334744503414 no 2909 0.101882271667483 953 1204976 SGTC_604 1000-0114 314 µM -1.27115796681365 0.132285908665554 no 2910 0.101836228360405 999 1572745 SGTC_821 1114-0266 29.2 µM -1.27311059856703 0.131917927088064 no 2911 0.101489399275747 979 3123235 SGTC_278 4092-0821 23.9 µM -1.27637248669994 0.131304786829141 no 2912 0.100911938665805 1007 877900 SGTC_1243 0416-0003 5.65 µM -1.27637892713107 0.131303578164934 no 2913 0.100910800873878 983 2141977 SGTC_2214 7179297 48.276 µM -1.27874311187153 0.130860414804988 no 2914 0.10049376632991 1007 769744 SGTC_225 nsc-122657 1.016 µM -1.27909013008031 0.130795453794867 no 2915 0.100432659425491 993 275685 SGTC_2845 9003024 42.97 µM -1.27923962898381 0.130767474814919 no 2916 0.100406342319881 972 2990173 SGTC_1935 st074532 41.6 µM -1.27924312046046 0.130766821428428 no 2917 0.100405727756384 969 2829742 SGTC_21 0849-0113 22.993 µM -1.28337108112094 0.12999590293905 no 2918 0.0996810502360505 1001 1560156 SGTC_1024 4507-0395 26 µM -1.28360842591091 0.129951673385417 no 2919 0.099639500033815 994 4201836 SGTC_2124 5246320 200 µM -1.28396318892189 0.129885582196881 no 2920 0.0995774178866491 976 579342 SGTC_1685 st024049 53.0905 µM -1.28447646021501 0.129790002630893 no 2921 0.099487647447392 982 1941139 SGTC_605 1315-0399 119 µM -1.28447785714783 0.129789742565476 no 2922 0.0994874032065123 989 24020461 SGTC_3250 9135583 49.47 µM -1.28537233604786 0.129623292516385 no 2923 0.0993311017508443 996 7699353 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.28546145823799 0.129606716223448 no 2924 0.0993155383584044 977 23665772 A membrane-active detergent. SGTC_1094 duloxetine 25.4 µM -1.28712538573866 0.129297503424724 no 2925 0.0990252942825998 997 60834 A selective serotonin reuptake inhibitor. SGTC_2341 7987486 176.74 µM -1.28870411904598 0.129004595576611 no 2926 0.0987504849748564 971 1258686 SGTC_1643 st009866 20.2 µM -1.29015269855237 0.128736240701046 no 2927 0.0984988228487391 957 3156273 YOR207C RET1 SGTC_1885 st057546 99.9 µM -1.29138308724897 0.12850861089088 no 2928 0.0982854361420335 953 702008 SGTC_484 loperamide 105 µM -1.29157064042557 0.128473936901892 no 2929 0.0982529384966617 984 3955 An opioid-receptor agonist. SGTC_3012 9080433 71.4286 µM -1.29375505605878 0.128070570196842 no 2930 0.0978750207359897 988 17688859 SGTC_1984 st072354 53.1 µM -1.29410822857307 0.128005437274924 no 2931 0.0978140198389654 973 5762938 SGTC_3290 9121031 71.43 µM -1.29582455068851 0.127689236711064 no 2932 0.0975179688942196 976 17014854 SGTC_1050 3232-1156 69.3 µM -1.29701216963766 0.127470757996563 no 2933 0.0973134997820978 994 700529 SGTC_2131 toluylene red 5.2905 µM -1.29880218053298 0.127141952474324 no 2934 0.0970059130736445 956 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_326 k292-0812 17.5 µM -1.30051731384925 0.126827455221315 no 2935 0.096711863046258 963 3579357 SGTC_1811 st050069 61.5 µM -1.30846855609649 0.125376544567498 no 2936 0.0953572164841613 990 3877702 SGTC_2977 9011197 71.43 µM -1.31173411961183 0.124784027087274 no 2937 0.0948049301423493 967 2704722 SGTC_1902 st060212 70.5 µM -1.31177864486216 0.12477596178472 no 2938 0.0947974161606249 967 688944 SGTC_36 0335-0881 14.2 µM -1.31314073144304 0.124529409470774 no 2939 0.0945677654833883 957 23828853 SGTC_1981 st071826 47 µM -1.31408690814136 0.124358341916435 no 2940 0.0944084796637272 979 11838600 SGTC_1861 st057647 17.4 µM -1.31677540747712 0.123873161777301 no 2941 0.0939569592565443 997 688668 SGTC_960 1222-0186 7.7 µM -1.31747547904048 0.123747041050598 no 2942 0.0938396475760855 998 3126296 SGTC_570 0987-0065 62.6 µM -1.31800809006558 0.123651149252633 no 2943 0.0937504698640044 951 3104428 SGTC_818 4072-2707 53.5 µM -1.32010257196541 0.123274561406568 no 2944 0.0934003870921659 979 882871 SGTC_3061 glucosamine 200 µM -1.32251690256169 0.122841462765017 no 2945 0.092998042353937 984 91431 and experimental redox chemotherapeutic SGTC_1494 4358-1428 177 µM -1.32429012639441 0.122524050497607 no 2946 0.092703354204258 986 1564571 SGTC_2221 6807166 181.081 µM -1.32539816596763 0.122326000557978 no 2947 0.0925195624985516 987 674925 SGTC_865 0488-0499 301 µM -1.32631659522037 0.122162011786642 no 2948 0.0923674261005852 977 9634651 SGTC_2941 9056145 11.23 µM -1.32697746117873 0.122044107380438 no 2949 0.0922580692552874 982 2119517 SGTC_2011 4012611 177 µM -1.32774176994239 0.121907847535136 no 2950 0.0921317147412974 1005 2049887 SGTC_135 0933-0004 26.348 µM -1.3354034197743 0.120547842815248 no 2951 0.0908721730556045 972 21230617 YGL099W LSG1 SGTC_1412 3909-8563 178 µM -1.3424065568102 0.119314106704645 no 2952 0.0897321049533794 1010 23767530 SGTC_1361 1608-0041 5.61 µM -1.34410808724926 0.119015699966882 no 2953 0.0894567186557682 985 X1361 SGTC_2035 5154463 94.595 µM -1.34415298898337 0.119007832446222 no 2954 0.0894494600016343 1005 2769623 SGTC_3090 9117696 49.47 µM -1.34461600583038 0.118926725713809 no 2955 0.0893746358978916 975 7923821 SGTC_2973 9094665 17.96 µM -1.34581972816089 0.118716052169988 no 2956 0.0891803307330916 985 25237061 YIL048W NEO1 SGTC_847 0342-0274 5.54 µM -1.34691067250076 0.118525344728868 no 2957 0.089004501923701 1002 18097 SGTC_2545 solidagenone 89.61 µM -1.34775458579014 0.118377969256268 no 2958 0.0888686645164189 954 6708572 An anti ulcer agent SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.35163347082258 0.117702252375634 no 2959 0.0882462987147621 993 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_827 3253-0474 693 µM -1.35261616829037 0.117531496908339 no 2960 0.0880891422272209 1002 5402065 SGTC_1071 trifluoperazine 6.31 µM -1.35499966356505 0.117118064790906 no 2961 0.0877088321093917 1026 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2794 7785382 27.27 µM -1.35667692445076 0.116827751758237 no 2962 0.087441943829905 986 2205081 SGTC_2148 5546263 113.568 µM -1.35909143506648 0.11641072626864 no 2963 0.0870588082768791 1023 792097 SGTC_585 0kpi-0023 191 µM -1.36243086209535 0.115835694479607 no 2964 0.0865309747553803 986 64601 SGTC_3038 9091290 49.47 µM -1.3666964320284 0.115104123426328 no 2965 0.0858602383454173 1002 25236843 SGTC_1124 fisetin 1.16336 µM -1.36758406081933 0.114952303568808 no 2966 0.0857211542301389 1003 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_3111 9122088 49.47 µM -1.36768816206522 0.114934507447304 no 2967 0.0857048534797285 988 16876704 SGTC_156 3474-0145 5.642 µM -1.37225939732601 0.114154985598673 no 2968 0.0849913502975737 979 2265471 SGTC_2365 9042475 200 µM -1.37309435409459 0.114013010095337 no 2969 0.0848615080102812 988 6464479 SGTC_934 2950-0684 338 µM -1.37451763251526 0.113771286831315 no 2970 0.0846405200272631 996 1121253 SGTC_2013 4024628 200 µM -1.37476061861039 0.113730055685567 no 2971 0.0846028355100452 1015 5230760 SGTC_2279 7948423 32.93 µM -1.38610205995301 0.11181741757714 no 2972 0.0828578707305547 985 1247112 SGTC_2369 9071472 200 µM -1.38851144781738 0.111414074810769 no 2973 0.0824906806400322 1002 17296037 SGTC_2854 9024559 71.43 µM -1.39542544162097 0.110262424380129 no 2974 0.0814437918547268 1000 3163529 SGTC_2572 astragaloside iv 100 µM -1.39886809345081 0.109692183136834 no 2975 0.0809262710503288 998 45006101 An anti-inflammatory agent. SGTC_2081 5214970 32.255 µM -1.39913153884827 0.109648633378481 no 2976 0.080886770786424 1015 2063512 SGTC_3129 9127257 49.47 µM -1.39930047294154 0.109620713673334 no 2977 0.0808614489427244 1007 837894 SGTC_3100 9120536 49.47 µM -1.39990050340633 0.10952158801689 no 2978 0.0807715576441701 996 16421196 SGTC_762 1165-0429 115 µM -1.40076556240473 0.109378792691307 no 2979 0.0806420949315718 994 5967793 SGTC_996 3970-0799 1.8 µM -1.40412039730057 0.108826275018948 no 2980 0.080141500326931 993 6615648 YGL040C HEM2 SGTC_2050 5263056 171 µM -1.40646912611805 0.108440652031475 no 2981 0.0797924330970964 1003 763468 YGL055W OLE1 SGTC_1722 st034304 3.6505 µM -1.4086007366419 0.108091528221941 no 2982 0.0794766304612048 1027 4036148 YLR033W RSC58 SGTC_720 r052-1644 49.9 µM -1.41774675347436 0.106602741340406 no 2983 0.0781323574017312 1014 1422863 YOR257W CDC31 SGTC_2298 7976326 193.81 µM -1.42062033303851 0.106138050677893 no 2984 0.077713582052211 1027 2235818 SGTC_1155 4088-0394 48.2 µM -1.42103161744767 0.106071661181491 no 2985 0.0776537839923717 1000 2326248 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.4215588239348 0.105986603439105 no 2986 0.0775771827179156 1013 688803 SGTC_976 1348-1067 47.6 µM -1.42380262305976 0.105625147611125 no 2987 0.0772518080940747 1016 5310671 YGL099W LSG1 SGTC_213 1246-0773 967 nM -1.42776635714719 0.104988805351273 no 2988 0.0766795596452611 1012 6251622 SGTC_1157 4092-0394 27.6 µM -1.428358844208 0.104893925737779 no 2989 0.0765942993289954 1016 3659885 SGTC_204 PMA1.184 62.41 µM -1.42945403975716 0.104718706920974 no 2990 0.0764368879040287 1015 2252213 YGL008C PMA1 SGTC_1708 st033234 31.827 µM -1.4309899611154 0.10447333422751 no 2991 0.0762165461435676 1004 674664 SGTC_496 calpeptin 138 µM -1.43300957684174 0.104151322817345 no 2992 0.0759275502398601 1003 73364 A calpain inhibitor. SGTC_2769 toremifene 3.73 µM -1.43327620095853 0.104108865579038 no 2993 0.0758894602290559 1008 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1216 1165-0504 9.65 µM -1.43331041208705 0.1041034187056 no 2994 0.0758845738692898 1031 6304004 SGTC_1519 esterone 74 µM -1.43332740349949 0.104100713520184 no 2995 0.0758821470827102 1023 698 A steroid. SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.43473501534372 0.103876786038754 no 2996 0.0756813110898412 1040 390807 SGTC_617 3770-0098 35 µM -1.4364877520972 0.103598443576724 no 2997 0.0754317995204149 1005 5962639 SGTC_1518 st038567 90.8 µM -1.43903159906829 0.103195432623547 no 2998 0.0750707850355003 1021 77966 SGTC_758 0868-0029 16 µM -1.43945560217075 0.103128370440919 no 2999 0.0750107402219346 988 762687 SGTC_2938 9059746 27.26 µM -1.4404677380007 0.102968414581313 no 3000 0.0748675556133042 1019 6471769 SGTC_1348 1493-0373 93.8 µM -1.44198609215169 0.102728795127187 no 3001 0.0746531485674713 1022 3010129 SGTC_747 3448-8087 38.7 µM -1.44289994497578 0.102584770704642 no 3002 0.0745243293369243 1032 5168703 SGTC_420 mitomycin C 81.9 mM -1.44428730365605 0.102366401786867 no 3003 0.0743290878345471 986 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_930 2810-3379 265 µM -1.44579023947456 0.102130222804745 no 3004 0.0741180222884736 1034 1015764 SGTC_3147 9097027 49.47 µM -1.44642980007023 0.10202983933175 no 3005 0.0740283442629121 1022 25236841 SGTC_2353 9059630 146.67 µM -1.44705332135624 0.101932042474549 no 3006 0.0739409950682524 1027 4779114 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.44834941707744 0.101728973294311 no 3007 0.0737596768409464 991 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2774 tamoxifen 10.92 µM -1.45378953202001 0.100879841443299 no 3008 0.073002333285248 1005 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_3292 9120825 59.784 µM -1.45714797903626 0.100358217676451 no 3009 0.0725377683744784 1001 24824900 SGTC_1435 4092-0789 56.7 µM -1.45820890044731 0.100193848410816 no 3010 0.0723914856280967 1013 2248285 SGTC_898 1000-0849 28.3 µM -1.45832243136173 0.100176270636997 no 3011 0.0723758450724015 1017 6751807 SGTC_3063 1327-0034 4 µM -1.45882724113662 0.10009813916631 no 3012 0.0723063314404024 999 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1677 st019204 53.9 µM -1.45904778257126 0.100064019035828 no 3013 0.0722759783685447 1012 3945625 SGTC_772 k072-0172 35.3 µM -1.45999808038472 0.0999170948787797 no 3014 0.0721453007531523 990 5861980 SGTC_401 neomycin 50 µM -1.46018337825808 0.0998884646105965 no 3015 0.0721198411334496 996 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_178 4092-0806 87.505 µM -1.46810484905634 0.0986701199774211 no 3016 0.0710378723169482 977 2169044 SGTC_753 1322-0200 289 µM -1.47762217374913 0.0972207564960138 no 3017 0.0697544679512358 1029 5403907 SGTC_2569 tetrandrine 100 µM -1.47801152128758 0.0971617983797809 no 3018 0.0697023472338296 1005 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2546 rhodinyl acetate 100 µM -1.48010713546978 0.0968449143661513 no 3019 0.0694223288126884 994 6708682 SGTC_219 mitoxanthrone 164.414 µM -1.48249305567331 0.0964850569088036 no 3020 0.0691045749958821 1043 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_988 1497-1057 103 µM -1.48266842487073 0.0964586455845906 no 3021 0.0690812638387283 1022 3533044 SGTC_2095 5432005 200 µM -1.48300099336633 0.0964085739875474 no 3022 0.0690370734230491 1027 783734 SGTC_989 1501-0895 10.3 µM -1.48438523439736 0.0962003674976498 no 3023 0.0688533748524544 1004 2830112 SGTC_1560 lithocholic acid 53.1 µM -1.485272873653 0.0960670299316369 no 3024 0.0687357772952338 994 9903 A bile acid which acts as a detergent. SGTC_3194 9111903 49.47 µM -1.48712965931672 0.095788550643786 no 3025 0.0684902847276515 1029 17087251 SGTC_451 chloral hydrate 100 µM -1.49076626457128 0.0952448566968443 no 3026 0.0680114358635662 1017 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1140 3229-1848 2.98 µM -1.49120653281258 0.0951791885071099 no 3027 0.0679536395244488 1020 2849525 SGTC_1686 st019653 115.5 µM -1.49260304818456 0.0949711119355887 no 3028 0.067770562491878 1042 97252 SGTC_2178 5812956 200 µM -1.49327824879162 0.0948706293449028 no 3029 0.0676821833984012 1018 5403383 SGTC_1491 4138-0063 26.5 µM -1.49425544565437 0.0947253427657133 no 3030 0.0675544327955851 1034 23883227 SGTC_3233 9132340 49.47 µM -1.49449348089928 0.0946899772777694 no 3031 0.0675233422832821 1027 17682950 SGTC_1976 st070609 63.5 µM -1.49479945965362 0.0946445315495165 no 3032 0.067483393704153 1016 682556 SGTC_1334 1486-0610 236 µM -1.49503275910984 0.0946098913733728 no 3033 0.0674529464068783 1006 3742339 SGTC_2287 7945887 168.79 µM -1.49634651546127 0.0944150000245105 no 3034 0.0672816897126136 1013 1245853 SGTC_3034 9090421 49.47 µM -1.50664883532415 0.0928969390127048 no 3035 0.065950346350323 1009 17173761 SGTC_1397 3532-0190 20.1 µM -1.5132939106819 0.0919273980237096 no 3036 0.065102509384681 1023 5322280 SGTC_845 0330-0138 4.51 µM -1.51395098697973 0.0918319368298643 no 3037 0.0650191354961147 1021 9039800 SGTC_2103 5378138 10 µM -1.51438310308106 0.0917691982812526 no 3038 0.0649643511300782 1015 244142 SGTC_1854 st056233 32.9 µM -1.51470930380438 0.0917218585270699 no 3039 0.0649230186233207 1034 5393174 SGTC_1998 st075797 76.8 µM -1.51578728486078 0.0915655456255034 no 3040 0.0647865741134047 1015 24208315 SGTC_80 0159-0065 512.242 µM -1.51885325990353 0.0911220424778821 no 3041 0.0643997181284927 1016 1548079 SGTC_1796 st049173 110.4 µM -1.51898937599047 0.0911023898467075 no 3042 0.064382585091545 1016 94134 SGTC_2616 abietic acid 100 µM -1.51951804037915 0.091026090356271 no 3043 0.0643160752871243 1027 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2485 5633444 17.78 µM -1.52295688124109 0.0905309362388904 no 3044 0.0638847467171096 1018 5724239 SGTC_1920 st075728 45.7 µM -1.52425182832932 0.0903449977170371 no 3045 0.0637229077907381 1004 3400306 SGTC_822 1487-0950 154 µM -1.52565864007672 0.0901433183767496 no 3046 0.0635474499844584 1004 1958375 SGTC_2114 5491910 81.25 µM -1.52676993098888 0.089984241251828 no 3047 0.0634091155605775 1022 2849228 SGTC_1434 4073-0095 163 µM -1.52704557073083 0.0899448167638391 no 3048 0.0633748400006546 1018 24133745 SGTC_2356 9061756 188.97 µM -1.53242223411407 0.0891783629680283 no 3049 0.0627091371194952 1025 20104043 SGTC_566 0958-0068 16.5 µM -1.53792816380652 0.0883985297041095 no 3050 0.062033090085069 1006 6815365 SGTC_478 N-arachidonylglycine 10 µM -1.54078251195183 0.087996259010474 no 3051 0.061684863533139 1049 5283389 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.54151713121914 0.0878929484137066 no 3052 0.0615954884016004 1026 688761 SGTC_3311 9131146 2.8755 µM -1.54245529042062 0.0877611452532387 no 3053 0.0614814972943088 1041 4900406 YPR165W RHO1 SGTC_3315 9136395 68.55 µM -1.54479133381745 0.0874335923253614 no 3054 0.061198372084429 1028 16876844 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.54645361381215 0.0872010687275847 no 3055 0.0609975272502487 1045 94937 An inhibitor of serotonin biosynthesis. SGTC_1942 st076330 65.2 µM -1.54746813470875 0.0870593822628045 no 3056 0.060875201287168 1026 24208414 SGTC_182 3448-4371 550.524 µM -1.55216084053669 0.0864062425046421 no 3057 0.0603118716765841 1019 3491403 SGTC_3201 9113999 49.47 µM -1.55553242716381 0.0859392453333742 no 3058 0.0599096589264705 1013 16649224 SGTC_230 MPP+ 141.667 µM -1.55620857138008 0.0858458206500409 no 3059 0.0598292519150127 1032 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_3218 9131285 49.47 µM -1.55819081048868 0.0855723673887684 no 3060 0.0595940113646836 1023 17156417 SGTC_365 0121-0052 13.6 µM -1.55895034745426 0.0854677609940684 no 3061 0.0595040662751237 997 3101739 SGTC_1875 nocodazole 6 µM -1.56579843314556 0.0845289366638344 no 3062 0.0586979065879846 1032 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_471 1-acyl-paf 4 µM -1.5659584828865 0.0845070878596728 no 3063 0.0586791684962436 1040 16759367 SGTC_1200 1643-0193 18.4 µM -1.56780845218116 0.0842548511898845 no 3064 0.058462920886112 1033 5403974 SGTC_3013 9080133 71.4286 µM -1.56784805187141 0.0842494580981667 no 3065 0.0584582988281639 1025 17050193 SGTC_1396 3511-0007 98.6 µM -1.56836776511278 0.0841787022335306 no 3066 0.0583976647259598 1019 X1396 SGTC_1988 st071872 53.4 µM -1.56891390573691 0.084104396512441 no 3067 0.0583340006182457 1032 16414116 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.56972154357774 0.0839946027853378 no 3068 0.0582399534743516 1003 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2913 7966556 36.57 µM -1.57091065762165 0.083833145484756 no 3069 0.0581017013462849 990 2976516 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.57248708462576 0.0836194585282437 no 3070 0.0579188160566497 1024 1241132 A phosphatase inhibitor. SGTC_522 1273-0010 11.6 µM -1.57630737381265 0.083103310744732 no 3071 0.0574774915487414 1008 5705015 SGTC_341 1486-1430 230 µM -1.58851336592581 0.0814702509209193 no 3072 0.056085150550463 1046 2054753 YPL210C SRP72 SGTC_1567 st069303 68.4 µM -1.58976378627993 0.0813043314279921 no 3073 0.0559440297991457 1027 5581319 SGTC_1126 isoteolin 1.0172 µM -1.59198646725946 0.0810100311937829 no 3074 0.0556938726437077 1023 133323 SGTC_3294 9122953 26.2835 µM -1.5938853806224 0.0807592378097687 no 3075 0.0554808547103775 1035 16459826 SGTC_1872 amphotericin b 148 nM -1.59526523318154 0.0805773659580684 no 3076 0.0553264683466697 1023 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1648 st011736 69.8 µM -1.60121272466827 0.0797969943570415 no 3077 0.0546649057207897 1042 2855514 SGTC_2718 lomofungin 53.02 µM -1.61113055764489 0.0785084073024988 no 3078 0.0535756346626419 1038 5351222 A RNA synthesis inhibitor. SGTC_3345 9148410 3.559 µM -1.61289399299195 0.078280951721689 no 3079 0.0533837702433013 1003 4903596 SGTC_2487 5918373 44.05 µM -1.61701553241732 0.0777512869743626 no 3080 0.0529374640798343 1043 2876279 SGTC_889 0919-1524 82.7 µM -1.6173064426314 0.0777140047306952 no 3081 0.052906074646459 1026 3905452 SGTC_942 3253-1115 227 µM -1.6184448792038 0.0775682363248852 no 3082 0.0527833783828949 1028 46497897 SGTC_1410 3909-8106 77.9 µM -1.61876824846674 0.0775268691596691 no 3083 0.0527485681020836 1038 1039210 SGTC_1350 1495-0454 146 µM -1.62255550159471 0.0770436292959725 no 3084 0.0523422297267587 1038 1069057 SGTC_2113 5491891 107.031 µM -1.62470241750451 0.0767707091030014 no 3085 0.052112991005241 1026 789979 SGTC_435 c-PAF 6.7 µM -1.63396625299463 0.0756014957309022 no 3086 0.0511329684005877 1018 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_615 k087-0205 167 µM -1.64519525180942 0.0742025019851417 no 3087 0.0499647761996491 1038 9642773 SGTC_1487 3970-0795 2.82 µM -1.64575171866966 0.0741336908126752 no 3088 0.0499074431286741 1022 3765103 SGTC_3337 9144342 33.5465 µM -1.64692722531233 0.0739884911235221 no 3089 0.0497865025601565 1029 17682949 SGTC_1939 st074455 53.6 µM -1.64942494888959 0.0736806914302771 no 3090 0.0495303034969724 1037 1644229 SGTC_2950 9072895 21.46 µM -1.6517377676005 0.0733965517021987 no 3091 0.0492940099862313 1023 17332245 SGTC_2009 4012297 12.05 µM -1.65278833952402 0.0732677615546828 no 3092 0.0491869740178366 1013 45595307 SGTC_864 0469-0573 172 µM -1.65389659975084 0.0731320868295551 no 3093 0.0490742618258549 1054 689425 SGTC_1553 gossypol 38.6 µM -1.65644410251663 0.0728209470011688 no 3094 0.0488159580437372 1022 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1815 st051655 58.2 µM -1.65734551808113 0.0727110954892922 no 3095 0.0487248197834931 1020 5984156 SGTC_2622 2-methoxyxanthone 59.94 µM -1.66226210219458 0.0721141655681272 no 3096 0.0482301164914799 1050 71034 A hepatoprotective. SGTC_1625 st003711 30.1 µM -1.66721702119153 0.0715163892254637 no 3097 0.0477356296833135 1033 24207034 YER133W GLC7 SGTC_2278 7948257 134.34 µM -1.66873997908822 0.0713334210437153 no 3098 0.04758446116829 1035 1247028 SGTC_2271 7849410 118.62 µM -1.66889477269622 0.0713148442726422 no 3099 0.0475691178756058 1046 972430 SGTC_59 0330-0160 1.33 µM -1.66965215969992 0.0712240038400464 no 3100 0.0474941020639614 1047 4293482 SGTC_621 3584-0052 32.1 µM -1.67158824421991 0.0709921951185581 no 3101 0.0473027722447826 1035 2273927 SGTC_134 0269-0018 6.916 µM -1.67264993038689 0.0708653249502753 no 3102 0.0471981156905568 1048 4378915 SGTC_1455 4262-0120 131 µM -1.67342485656243 0.0707728322604725 no 3103 0.0471218439711752 1033 1529587 SGTC_2799 7812892 81.82 µM -1.6751169303825 0.0705711942038104 no 3104 0.0469556458899065 1017 20205235 SGTC_675 1309-0189 238 µM -1.67563525176176 0.0705095162296123 no 3105 0.0469048297287544 1039 4246530 SGTC_1554 st069299 38.7 µM -1.67628995601469 0.0704316685278776 no 3106 0.0468407056597 1033 24207999 SGTC_2745 rifampicin 24.3 µM -1.678366708197 0.0701851692276199 no 3107 0.0466377663175228 1048 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_587 k089-0003 57 µM -1.68076545921345 0.0699012768549438 no 3108 0.0464042401214275 1028 9659696 SGTC_1270 0831-1170 17.3 µM -1.6848293875715 0.0694223284277217 no 3109 0.0460107466392796 1034 6764716 SGTC_3138 9097216 49.47 µM -1.68663688786043 0.0692101218484491 no 3110 0.0458365972089623 1044 25237486 SGTC_2498 4'-Methoxychalcone 54.63 µM -1.68956255111163 0.068867698815938 no 3111 0.0455558377509245 1044 641818 YHR062C RPP1 SGTC_142 0335-0849 62.6745 µM -1.6969722696971 0.0680062998781361 no 3112 0.0448509516600505 1020 3889043 YPR107C YTH1 SGTC_304 1310-0298 97 µM -1.7056971405271 0.0670027028725848 no 3113 0.0440322411704242 1047 1550234 SGTC_740 k014-0057 261 µM -1.70737797408428 0.0668106840691206 no 3114 0.0438759107903222 1045 4012779 SGTC_192 3455-0609 60.9 µM -1.70744063983507 0.0668035333611317 no 3115 0.0438700910638933 1044 3769639 SGTC_1143 3454-2408 5.08 µM -1.70783883505241 0.0667581096538961 no 3116 0.0438331254870551 995 X1143 SGTC_3302 9125395 16.351 µM -1.70831477891194 0.0667038482097491 no 3117 0.0437889752542214 1037 17599668 SGTC_1969 st069479 40.1 µM -1.70999315282616 0.0665127723930543 no 3118 0.043633569611498 1042 3895485 SGTC_2715 st079500 56.4 µM -1.71202289120787 0.066282261578867 no 3119 0.0434462250006443 1045 28246688 SGTC_3105 9121040 49.47 µM -1.71276038734143 0.0661986599361695 no 3120 0.0433783152387427 1013 41448907 SGTC_462 ag-879 158 µM -1.71287948240634 0.0661851671308827 no 3121 0.0433673568260662 1044 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_406 estrone 100 µM -1.7154008118679 0.0659000142423833 no 3122 0.0431358833335747 1038 5870 A steroid. SGTC_403 arphamenine a 50 µM -1.71890762966855 0.0655049904814465 no 3123 0.0428155963389461 1044 5487158 An arginine aminopeptidase inhibitor. SGTC_2432 5630864 12.22 µM -1.72198474565106 0.0651598850439112 no 3124 0.0425361409231545 1045 5714970 SGTC_2767 sibutramine 71.45 µM -1.72945568849481 0.064327873492744 no 3125 0.0418637852871093 1052 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2919 7978188 46.38 µM -1.73288664124764 0.0639485578894981 no 3126 0.0415579095543712 1044 2980291 SGTC_2416 tofa 880 nM -1.73763863188352 0.0634260679938166 no 3127 0.0411372541251734 1031 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2988 9073640 71.4286 µM -1.7405758872385 0.0631047769690973 no 3128 0.0408789736684718 1050 9102229 SGTC_110 0850-0284 111.64 µM -1.74105785873996 0.0630521778930005 no 3129 0.0408367185801374 1024 3906265 SGTC_610 4215-0184 155 µM -1.74486669273251 0.0626377081788767 no 3130 0.0405040381586615 1010 5605015 SGTC_1927 st060202 13.8 µM -1.75576697031256 0.0614632921096241 no 3131 0.0395641031703128 1035 688887 SGTC_1768 st044301 37.178 µM -1.75673841919264 0.0613594667378019 no 3132 0.0394812028908937 1063 3931349 SGTC_1650 st011916 45.8 µM -1.75781941115436 0.0612440948633006 no 3133 0.0393891207184396 1056 242528 SGTC_3269 9137823 49.47 µM -1.76086392078443 0.0609200719627676 no 3134 0.0391307188885877 1027 17682936 SGTC_2229 7354935 190 µM -1.76492668897962 0.0604897667320261 no 3135 0.038788043767256 1053 318112 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.76601964875592 0.0603744135489069 no 3136 0.0386962762398142 1049 115019 SGTC_973 1325-0077 65.9 µM -1.76814332055993 0.060150769226183 no 3137 0.0385184734112776 1064 2835149 SGTC_27 0485-0001 32.618 µM -1.77089435858824 0.0598620217435092 no 3138 0.0382891353279289 1030 2054479 SGTC_358 0075-0058 9.45 µM -1.77217763131704 0.0597277020120797 no 3139 0.0381825377664539 1056 1069125 SGTC_3185 9108267 49.47 µM -1.77490078762583 0.0594434524325122 no 3140 0.0379571351160704 1051 4910486 SGTC_1914 st062367 72.6 µM -1.77550099713371 0.0593809439760151 no 3141 0.0379076005282704 1041 978205 SGTC_1751 st044839 27.194 µM -1.78210066587297 0.0586970192334022 no 3142 0.0373664086274597 1047 5291326 SGTC_1374 2889-5571 141 µM -1.78235095097338 0.0586712043505106 no 3143 0.0373460093858099 1044 2853281 SGTC_684 1140-0066 328 µM -1.78295562654034 0.0586088737330634 no 3144 0.037296763433027 1055 6813534 SGTC_2173 5763948 167 µM -1.78617167990367 0.058278232544452 no 3145 0.0370357325006036 1056 2867177 SGTC_2670 beta-carotene 100 µM -1.78704736811198 0.0581884576528257 no 3146 0.0369649165092203 1039 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1473 k844-0725 134 µM -1.79110214331806 0.057774180715828 no 3147 0.0366384526462846 1052 54682906 SGTC_3084 9116877 49.47 µM -1.80284412155727 0.0565875744179467 no 3148 0.0357063493547421 1051 27241325 SGTC_2282 7944268 200 µM -1.8072178541697 0.0561505193409237 no 3149 0.0353641590936571 1049 2970414 SGTC_1322 1348-1070 12 µM -1.80836849903423 0.056035981933323 no 3150 0.0352745836404067 1053 6758089 SGTC_1246 0422-0085 105 µM -1.81410251275678 0.0554679519265315 no 3151 0.0348309723966382 1038 264295 SGTC_1793 st048256 72.231 µM -1.82057730671984 0.0548320132897726 no 3152 0.0343355675099772 1033 672022 SGTC_2208 7283366 200 µM -1.82205164881363 0.0546880155937484 no 3153 0.0342235745967697 1051 898663 SGTC_323 4013-0906 34.3 µM -1.82514015699761 0.0543873329797924 no 3154 0.0339899408165783 1050 2910086 SGTC_2497 7-hydroxyflavone 100 µM -1.82863541455797 0.0540486302454655 no 3155 0.0337271218351489 1045 5281894 SGTC_1184 1269-1718 139 µM -1.82952731861269 0.0539624695373171 no 3156 0.0336603253282952 1046 5403821 SGTC_2479 5617353 43.85 µM -1.82958918439911 0.053956497144833 no 3157 0.0336556961143802 1040 2731746 SGTC_716 1683-5115 658 µM -1.83035234139589 0.0538828666135584 no 3158 0.0335986346619522 1044 723597 SGTC_1118 chelidonine 707.474 nM -1.83064474880752 0.0538546757979315 no 3159 0.0335767923918366 1062 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_380 3970-0968 6 µM -1.83170101608954 0.0537529390083502 no 3160 0.0334979886048672 1059 2891601 SGTC_2146 5545642 200 µM -1.83849767104942 0.053101939785875 no 3161 0.0329945523621702 1050 825326 SGTC_1978 st071761 42 µM -1.84108438331238 0.0528558270573561 no 3162 0.0328045969120507 1055 5147680 SGTC_849 0386-0493 241 µM -1.84258726356672 0.0527132516290908 no 3163 0.0326946474518858 1059 726119 SGTC_1591 genipin 88.4 µM -1.84391976772028 0.0525870948436615 no 3164 0.0325974168830847 1060 442424 A DNA cross-linking agent. SGTC_863 0466-0191 129 µM -1.84475424817383 0.0525082112817714 no 3165 0.0325366477878964 1065 765160 YPR165W RHO1 SGTC_1631 benzylvanillin 81.9 µM -1.84621194269569 0.052370640568313 no 3166 0.0324307187809404 1027 75506 SGTC_2123 5259487 200 µM -1.85749212426007 0.0513157199355482 no 3167 0.0316205853281243 1057 2173474 SGTC_2063 5246145 200 µM -1.86326881941272 0.0507820673155947 no 3168 0.0312122273594687 1059 711240 SGTC_3313 9133968 57.047 µM -1.86427343236437 0.0506897135956266 no 3169 0.0311416578771307 1040 1494643 SGTC_1785 bathophenanthroline 24 µM -1.8644388305577 0.0506745214292754 no 3170 0.0311300520717509 1001 72812 An iron chelator. SGTC_2107 5363541 170.161 µM -1.87194874816496 0.0499885321122181 no 3171 0.0306068472192166 1053 244052 SGTC_839 0122-0028 230 µM -1.87592041110362 0.0496287479675607 no 3172 0.0303331047214288 1042 759448 SGTC_2841 9004761 38.96 µM -1.88427222930263 0.0488789172668639 no 3173 0.029764080905158 1044 2991039 SGTC_2090 5301565 104.445 µM -1.8873034496908 0.048609022255697 no 3174 0.0295597613646469 1059 2056344 SGTC_2291 7917025 104.35 µM -1.88945214920873 0.0484184281056323 no 3175 0.0294156343918752 1047 2964612 SGTC_1482 3346-2049 8.48 µM -1.89111462634977 0.0482713733880999 no 3176 0.0293045222317477 1066 3826804 SGTC_2389 9091542 195.52 µM -1.89169415414654 0.0482201952144687 no 3177 0.0292658713399833 1051 3626624 YOL127W RPL25 SGTC_2243 6634756 200 µM -1.89733118493497 0.0477246499677688 no 3178 0.0288921208195161 1042 885676 SGTC_3162 9099653 49.47 µM -1.9032310930791 0.047210371854443 no 3179 0.0285051988238403 1061 25237511 SGTC_1060 3448-7350 82 µM -1.9117548764165 0.0464752330715259 no 3180 0.0279538209966998 1049 570178 SGTC_2143 5623677 140.463 µM -1.91652750356525 0.0460676448327785 no 3181 0.0276489929169662 1043 5375313 SGTC_1603 st002045 67.8 µM -1.91792405678023 0.0459489220270658 no 3182 0.0275603206810892 1066 5887985 SGTC_2907 7721985 69.9 µM -1.92086335756677 0.0456998514210023 no 3183 0.0273744681834287 1060 3267881 SGTC_174 3553-0389 74.3 µM -1.9229813922884 0.045521046966881 no 3184 0.0272411933940554 1065 738071 SGTC_31 0508-1974 57.237 µM -1.92786791196619 0.045110672820099 no 3185 0.0269357789395152 1052 6810525 SGTC_567 1080-0542 68.4 µM -1.93025648286842 0.0449111646416032 no 3186 0.0267875330738104 1051 5950415 SGTC_1363 1636-0063 10.4 µM -1.93415843647085 0.0445867779365351 no 3187 0.0265468254548505 1069 6072185 SGTC_2138 5575593 77.673 µM -1.93524095696029 0.0444971184195018 no 3188 0.0264803669656577 1052 762213 SGTC_112 phenothiazine 287.218 µM -1.93612056234555 0.0444243723160301 no 3189 0.0264264683424165 1071 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_632 0781-2353 4.65 µM -1.93741291842869 0.0443176643068027 no 3190 0.026347444373739 1073 6811515 YHR007C ERG11 SGTC_2508 celastrol 40.54 µM -1.94248465712027 0.0439008925294557 no 3191 0.0260392277825673 1036 122724 Celastrol is a natural product and antioxidant. SGTC_2196 6573537 42.6665 µM -1.94665712901098 0.043560393487509 no 3192 0.025787927285127 1078 2903087 SGTC_34 0469-0683 81.75 µM -1.9477232102671 0.0434737375204169 no 3193 0.0257240456673872 1055 3690923 SGTC_2601 securinine 100 µM -1.9643647454491 0.0421389913064465 no 3194 0.0247439040938144 1045 442872 A GABA receptor antagonist. SGTC_1489 4065-0444 182 µM -1.96846174786413 0.0418155274020276 no 3195 0.0245074666155422 1054 2877968 SGTC_226 1,3-diallylurea 8.28947 mM -1.98082866879081 0.0408513205246218 no 3196 0.0238052453043908 1069 74537 YKL182W FAS1 SGTC_2270 7924575 90.91 µM -1.98335607500958 0.0406565043141455 no 3197 0.0236638349459927 1054 1262135 SGTC_2402 5553605 200 µM -1.9859041519751 0.0404608587509254 no 3198 0.023521983814117 1066 6758546 SGTC_1808 st050063 61.5 µM -1.988347621203 0.0402739637814449 no 3199 0.0233866287163497 1062 4011993 SGTC_1877 wortmannin 25 µM -1.99621667279576 0.03967683956019 no 3200 0.0229551717065698 1068 312145 A covalent inhibitor of PI 3-kinase. SGTC_2898 9056270 58.44 µM -2.01073372012112 0.0385941477178281 no 3201 0.0221767951479272 1040 19154699 SGTC_2729 fluphenazine 10.66 µM -2.01114502454766 0.0385638265865591 no 3202 0.0221550703027176 1059 3372 An atypical antipsychotic. SGTC_735 3076-0345 636 µM -2.01196067615028 0.0385037546281066 no 3203 0.0221120412116848 1062 2888990 SGTC_713 1488-1073 324 µM -2.01461505299353 0.0383087900658317 no 3204 0.0219724995026827 1072 3312542 SGTC_3266 9136860 49.47 µM -2.01619808880947 0.038192899396448 no 3205 0.0218896331046644 1026 4871271 YPR165W RHO1 SGTC_2395 5646831 180.19 µM -2.01649743990733 0.0381710167192497 no 3206 0.0218739928276064 1072 6808628 SGTC_2431 5490079 200 µM -2.01775725351413 0.0380790359127144 no 3207 0.0218082744003961 1071 5722345 SGTC_1167 k781-0610 148 µM -2.03357489285426 0.0369394799589461 no 3208 0.0209972376985361 1054 4525169 SGTC_412 gemfibrozil 100 µM -2.03565025033837 0.0367920548920309 no 3209 0.0208927440206036 1061 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_3048 9093155 49.47 µM -2.03842763923169 0.0365955135121759 no 3210 0.0207535922564291 1057 25236002 SGTC_322 k048-0136 19.3 µM -2.03874963560083 0.0365727831681597 no 3211 0.0207375105893307 1075 6823282 SGTC_324 1315-0088 19.6 µM -2.042947653324 0.0362774926059607 no 3212 0.02052881015018 1074 6787421 SGTC_468 gf-109203x 121 µM -2.0483431120875 0.0359008426240428 no 3213 0.0202631957263351 1086 2396 A protein kinase C inhibitor. SGTC_1041 0206-0046 107 µM -2.04928945894853 0.0358351107699004 no 3214 0.0202169093966288 1067 50494 SGTC_57 miconazole 162.5 nM -2.05384593228166 0.0355200038657358 no 3215 0.0199953028605691 1044 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_838 0109-0203 71.4 µM -2.05451565392504 0.0354738807431904 no 3216 0.0199629049371091 1063 759422 SGTC_3265 9137266 49.47 µM -2.05602677328631 0.0353699917132418 no 3217 0.0198899678064051 1069 17224265 SGTC_841 0251-0215 91.2 µM -2.05886445205634 0.0351755763494422 no 3218 0.019753612641346 1077 3888614 SGTC_2962 9082311 13.18 µM -2.07070413952634 0.0343738524084063 no 3219 0.0191932265781228 1068 16459453 SGTC_1329 1447-1697 50.6 µM -2.07560301351835 0.0340465466782905 no 3220 0.0189653412515436 1074 2840515 SGTC_2393 9031399 185.94 µM -2.08386669355131 0.0335002402554865 no 3221 0.0185861473492732 1065 1526623 YDL150W RPC53 SGTC_1007 4101-0031 70 µM -2.10826938001664 0.031928976895731 no 3222 0.0175038474834384 1081 1146276 SGTC_2383 9036125 200 µM -2.11096874081008 0.0317589691769191 no 3223 0.0173874993897712 1071 79580 SGTC_2917 7979103 53.79 µM -2.11499867328088 0.0315065533586251 no 3224 0.0172150301955418 1062 2980565 SGTC_2646 retinol 96.75 µM -2.11620200803593 0.0314315045059709 no 3225 0.017163815258943 1066 445354 A vitamin A analog and teratogen. SGTC_1703 st026983 48.3 µM -2.1174450632408 0.0313541336487355 no 3226 0.0171110465567467 1066 1104023 SGTC_1748 st037455 53.6035 µM -2.12150629180464 0.0311024496813461 no 3227 0.0169396095139735 1072 580690 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -2.13161384805066 0.030483309872626 no 3228 0.0165193021927468 1070 551469 SGTC_3347 9188721 44.724 µM -2.14171022907333 0.029875082689936 no 3229 0.0161084035386285 1082 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -2.14522138627476 0.0296659365242035 no 3230 0.0159675752372011 1072 688751 SGTC_2947 9072639 7.68 µM -2.145846790315 0.0296288113869586 no 3231 0.015942602089173 1075 16488146 SGTC_2193 5925765 200 µM -2.16485349660754 0.0285187997357708 no 3232 0.0151994532274729 1067 877370 SGTC_2375 9072683 200 µM -2.16672910360906 0.0284111626597821 no 3233 0.0151277580382016 1071 16798029 SGTC_1607 st000305 50.6 µM -2.173281475543 0.0280377858656998 no 3234 0.0148795694201715 1076 5457690 SGTC_9 0092-0002 10.449 µM -2.18254601678085 0.0275168412775125 no 3235 0.0145346294739386 1079 759368 SGTC_1365 1672-3266 55.4 µM -2.18623481107864 0.0273116788625978 no 3236 0.014399215332091 1061 6415873 SGTC_1042 0350-0096 82 µM -2.18996944379931 0.0271052683372118 no 3237 0.0142632264726868 1070 3122515 SGTC_2909 7941780 10.49 µM -2.19109472465421 0.0270433306496748 no 3238 0.0142224692041217 1067 1243215 SGTC_1525 8-methoxypsoralen 92.5 µM -2.19170877145027 0.0270095821403782 no 3239 0.0142002709896561 1079 4114 Related to psoralen; DNA damaging agent. SGTC_2385 9074692 200 µM -2.19529413523804 0.026813228751379 no 3240 0.0140712526685675 1076 17046906 SGTC_3087 9117406 49.47 µM -2.20118265142329 0.0264933295372726 no 3241 0.0138615479769898 1070 42546093 SGTC_1391 3442-0225 151 µM -2.20482493384716 0.0262970600753416 no 3242 0.0137331908356736 1074 5227075 SGTC_991 3996-0057 64.7 µM -2.20535520784116 0.0262685871387989 no 3243 0.0137145892980625 1075 715343 SGTC_319 1348-1596 45.5 µM -2.21522812683366 0.0257431525537284 no 3244 0.0133722051138601 1072 5380505 SGTC_933 2914-0560 114 µM -2.21558316958334 0.0257244223083511 no 3245 0.0133600312834663 1072 463887 SGTC_306 1672-3436 11.6 µM -2.21673474913617 0.0256637493240762 no 3246 0.0133206113655483 1078 6797378 SGTC_859 0439-0102 54.6 µM -2.21927706802128 0.0255302268811868 no 3247 0.0132339403684568 1074 610143 SGTC_1996 st072960 66.8 µM -2.22382412529883 0.0252928663253794 no 3248 0.0130801397803729 1078 1719405 SGTC_1279 0874-0590 65.2 µM -2.22796671835516 0.0250782314107796 no 3249 0.0129413672260744 1077 3523074 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -2.27072440807112 0.0229507488865984 no 3250 0.0115818332448178 1064 6728940 SGTC_1288 0973-0013 65.5 µM -2.27602743396802 0.0226978059406998 no 3251 0.011422183842993 1083 4315430 SGTC_1034 k072-0165 12.7 µM -2.28392741277821 0.0223253537771103 no 3252 0.011187898634088 1079 5835461 SGTC_2311 7694451 200 µM -2.2913812588918 0.0219786752475493 no 3253 0.0109706862677205 1078 2163142 SGTC_2876 9059903 25.97 µM -2.29426540729814 0.0218457584593922 no 3254 0.010887629154731 1076 6916095 SGTC_2460 5552655 174.22 µM -2.29532055821125 0.0217973014410851 no 3255 0.0108573801485891 1075 5401989 SGTC_1084 voriconazole 435 nM -2.29965429035754 0.0215992291426844 no 3256 0.0107339068459394 1080 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_130 0136-0219 337.655 µM -2.3037801508015 0.0214120729983757 no 3257 0.0106174939518711 1071 234244 SGTC_185 k048-0037 25.491 µM -2.31486616237611 0.0209159713979736 no 3258 0.0103101288468339 1077 6827589 SGTC_2190 6049624 200 µM -2.3208928509874 0.0206503818685612 no 3259 0.0101463137445215 1075 2265554 SGTC_1794 st048918 76.9 µM -2.32634769471132 0.020412461068388 no 3260 0.0100000047795169 1057 672303 SGTC_2981 9013952 38.96 µM -2.34896070944231 0.0194507882725134 no 3261 0.00941294661964424 1070 2996344 SGTC_2681 menadione 3.18 µM -2.35807636565347 0.0190741544071714 no 3262 0.00918495677067469 1077 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_664 1222-0054 14.9 µM -2.36087784550903 0.0189596580133775 no 3263 0.00911586746652431 1081 6813991 SGTC_2994 9053520 71.4286 µM -2.37895614139569 0.018234768718666 no 3264 0.00868087077360104 1081 4647384 SGTC_3350 9150499 3.57 µM -2.43005320868782 0.0163123652667244 no 3265 0.00754830318147915 1080 4910996 YPR165W RHO1 SGTC_1653 st012112 65 µM -2.43945986975261 0.0159780661170524 no 3266 0.00735461815314972 1084 720429 SGTC_3045 9092950 49.47 µM -2.44192147044125 0.0158915600711276 no 3267 0.00730466206669905 1080 44120432 SGTC_194 1486-1323 56.904 µM -2.44450449569926 0.015801218983269 no 3268 0.00725256364891124 1084 5178754 SGTC_3160 9100216 49.47 µM -2.44824715472359 0.0156711014528016 no 3269 0.00717765730061464 1082 17191039 SGTC_1932 st074806 40.9 µM -2.45010310337422 0.0156069190926642 no 3270 0.00714076569540435 1071 17251235 SGTC_2960 9079389 5.97 µM -2.4634206071642 0.0151529561476694 no 3271 0.00688091848770286 1073 16457355 SGTC_2301 7769476 200 µM -2.46896404540366 0.0149673640393537 no 3272 0.00677524163410064 1073 977820 SGTC_1100 amiodarone 5.07 µM -2.48553505097921 0.014424180135315 no 3273 0.00646784239031051 1084 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1328 1441-0025 69.2 µM -2.49418246754548 0.0141475255202547 no 3274 0.00631238133710051 1088 4562601 SGTC_783 0848-0141 92.7 µM -2.49669743380935 0.0140679280249933 no 3275 0.00626779322676168 1086 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2510 benzyl isothiocyanate 8.31 µM -2.49851122510235 0.0140107622085194 no 3276 0.00623580963345575 1065 2346 DNA damaging agent; causes G2/M arrest. SGTC_325 2810-4341 181 µM -2.52242236458852 0.0132756665729553 no 3277 0.00582748369252738 1079 774970 SGTC_189 3970-0742 2.116 µM -2.52884443712013 0.0130840025321896 no 3278 0.00572193685192702 1080 2891807 SGTC_1055 3448-0672 86 µM -2.53237192266799 0.0129797473829968 no 3279 0.0056646875198713 1076 748378 SGTC_188 3229-0966 278.469 µM -2.53585278748026 0.0128775749506247 no 3280 0.00560869391188864 1079 5722370 SGTC_2644 guaiazulene 100 µM -2.5392318389755 0.0127790571071632 no 3281 0.00555480881817837 1084 3515 A coloring agent. SGTC_1061 3448-9325 110 µM -2.53988778927049 0.0127600083251245 no 3282 0.00554440196492317 1079 723482 SGTC_359 0081-0058 15.9 µM -2.54170335337554 0.0127074124283191 no 3283 0.00551568773980867 1072 3494159 SGTC_815 1582-0027 36.9 µM -2.54453527052434 0.0126257478619942 no 3284 0.00547116301825753 1085 3128206 SGTC_2641 levomentholum 100 µM -2.54680752580658 0.0125605512154148 no 3285 0.00543566881673453 1087 16666 SGTC_2752 diclazuril 33.15 µM -2.57735508070746 0.0117119632169645 no 3286 0.00497798096023594 1077 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_3176 9106582 49.47 µM -2.57893196075177 0.0116695427125515 no 3287 0.00495531524221952 1089 17018027 SGTC_2242 6630449 61.2675 µM -2.59765556279142 0.0111759546671488 no 3288 0.00469312966479984 1082 691249 YDR170C SEC7 SGTC_3164 9100705 49.47 µM -2.59849228403555 0.0111543273866803 no 3289 0.00468170746797563 1086 17174235 SGTC_2703 st077852 53.4 µM -2.60441946519097 0.0110021630144383 no 3290 0.00460150232807278 1080 6281836 SGTC_2294 7971431 200 µM -2.61555151128463 0.0107212533723301 no 3291 0.00445417414809067 1089 5741572 SGTC_2083 5306046 65.942 µM -2.63001527678242 0.0103656126162547 no 3292 0.00426905156541509 1081 539837 SGTC_1524 corynanthine 62.1 µM -2.68664297150054 0.00907032938989313 no 3293 0.00360870264215836 1079 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_127 0180-0333 59.125 µM -2.72003673323065 0.00837487375135076 no 3294 0.00326373323463611 1063 771601 SGTC_1975 st070967 30.8 µM -2.73736535022214 0.00803278688530372 no 3295 0.0030966734066065 1085 261391 SGTC_2975 9084847 53.72 µM -2.74181838513239 0.00794688757586644 no 3296 0.00305500570920379 1080 27211724 SGTC_1908 st060353 56.5 µM -2.74895804421549 0.00781084843250257 no 3297 0.00298925191122093 1084 4227716 SGTC_111 0083-0039 52.457 µM -2.76043345141133 0.00759648696427469 no 3298 0.00288623586094823 1092 759313 SGTC_3108 9121785 49.47 µM -2.76354251837227 0.007539308617681 no 3299 0.00285888212082824 1050 17140271 SGTC_886 0866-0150 153 µM -2.77415974972292 0.00734689620306964 no 3300 0.00276722469116879 1089 271463 SGTC_2299 7976368 114.88 µM -2.82789386648388 0.00643799802147119 no 3301 0.00234276688588951 1083 2979718 SGTC_1333 1482-0047 286 µM -2.84697729294963 0.00614000903524708 no 3302 0.00220682552351223 1088 3811116 SGTC_2746 daunorubicin 9.88 µM -2.85429107537345 0.00602908370930634 no 3303 0.002156649586276 1093 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -2.85466388773157 0.00602347729034868 no 3304 0.00215411984788766 1090 688662 SGTC_2685 mycophenolic acid 18.85 µM -2.85550692828756 0.0060108165323122 no 3305 0.00214840926899356 1091 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2506 ethyl hematommate 54.16 µM -2.87633918835142 0.00570536148503286 no 3306 0.00201158567782804 1084 3940691 An allergen. SGTC_2963 9082507 9 µM -2.89465449349185 0.0054482775334889 no 3307 0.00189788035814642 1093 16459611 SGTC_2916 7875993 68.79 µM -2.91800770089205 0.00513543972731259 no 3308 0.00176137824881485 1088 1299250 SGTC_2568 diosmetin 100 µM -2.91835275045524 0.0051309398728626 no 3309 0.00175943013494656 1085 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1876 myriocin 605 nM -2.92175285347171 0.00508678584600627 no 3310 0.00174033808684971 1085 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1326 1431-2094 10.8 µM -2.95264750912529 0.00470083145013601 no 3311 0.00157530750460419 1091 616278 SGTC_1520 flindersine 88 µM -2.96438398810106 0.00456120157317504 no 3312 0.00151644787932457 1082 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1528 arabinosylhypoxanthine 74.6 µM -2.99039975946071 0.00426480931109843 no 3313 0.00139306278858366 1088 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1716 st033144 30.6155 µM -3.03926099443952 0.00375431679581771 no 3314 0.00118579648958025 1086 674617 SGTC_50 0929-0078 56.389 µM -3.07200654025034 0.00344358497337073 no 3315 0.0010631253320236 1083 1377751 SGTC_2337 9009472 200 µM -3.08077809762518 0.00336437098326037 no 3316 0.00103230226309584 1087 5742383 SGTC_1561 5-methoxyflavone 52.9 µM -3.09881845474592 0.00320658026903075 no 3317 0.000971470184500373 1086 94525 SGTC_775 4577-0580 57.3 µM -3.14676901057855 0.0028190416423668 no 3318 0.000825426615517884 1092 2006902 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -3.17600401135071 0.00260402154154238 no 3319 0.000746594432352283 1094 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1848 st056003 16.4 µM -3.19477252816121 0.00247390814532897 no 3320 0.000699705455951699 1090 146492 SGTC_2275 7947463 200 µM -3.21672032776166 0.00232923136276763 no 3321 0.000648324646898382 1084 1225414 SGTC_957 1187-1561 14.1 µM -3.25181521444086 0.00211374752467368 no 3322 0.000573352730032341 1091 1538454 SGTC_1798 st045719 60.953 µM -3.2623211693287 0.00205285198267309 no 3323 0.000552519348960678 1090 3980186 SGTC_2409 alverine citrate 63.97 µM -3.37080157760839 0.00151096407917385 no 3324 0.000374749101923072 1083 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_65 0798-0905 34.986 µM -3.38976942497205 0.00143087935964073 no 3325 0.000349757163655699 1091 3602145 SGTC_3043 9092303 49.47 µM -3.40533701621075 0.00136806750101638 no 3326 0.00033041223048814 1092 25236084 SGTC_2499 avocadenofuran 51.48 µM -3.43534190587005 0.00125405852140177 no 3327 0.000295903326747402 1093 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_3320 9137005 35.139 µM -3.49010477658047 0.00106811652365476 no 3328 0.000241415601955365 1094 4908713 SGTC_857 0438-0306 1.35 µM -3.50831949517943 0.00101210899571539 no 3329 0.000225473566220757 1092 4686136 SGTC_2302 7771753 200 µM -3.54527667920041 0.000906664177054869 yes 3330 0.000196100585004969 1083 2203047 SGTC_2602 kawain 100 µM -3.54743220659078 0.000900837352473455 yes 3331 0.000194502925910497 1089 5369129 SGTC_2522 biochanin a 4.94 µM -3.5705473692814 0.000840480143394136 yes 3332 0.000178118010916437 1093 5280373 A possible chelator. SGTC_220 paclitaxel 373.376 µM -3.73017441635373 0.000515154951341143 yes 3333 9.56736318711666e-05 1090 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1904 st060225 78 µM -3.78986566539102 0.000426947583495847 yes 3334 7.53643882732192e-05 1084 66595 SGTC_186 3455-3465 67.277 µM -3.80179274793618 0.000411094829217391 yes 3335 7.18264356865805e-05 1093 755278 SGTC_3260 9137109 49.47 µM -3.84896852534458 0.000353593289333067 yes 3336 5.93081228329025e-05 1093 17478346 SGTC_1856 st057054 55.7 µM -3.95879850030928 0.000247413492072783 yes 3337 3.76638770039756e-05 1094 1266018 SGTC_2964 9083345 53.42 µM -4.04279975411502 0.000187165807329207 yes 3338 2.64083627620256e-05 1091 17741579 SGTC_1892 st058411 7.36 µM -4.0872111914312 0.000161154418626486 yes 3339 2.18294828945179e-05 1095 3934738 SGTC_1082 camptothecin 424.86 nM -4.18789774462684 0.000114178860671674 yes 3340 1.40775155485942e-05 1086 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3133 9127736 49.47 µM -4.42934524685882 4.84738333844744e-05 yes 3341 4.72598040495984e-06 1095 27243420 SGTC_116 0155-0182 31.788 µM -4.62706241791992 2.32754378203515e-05 yes 3342 1.85444381371959e-06 1042 771486 SGTC_2536 dehydroabietamide 32.04 µM -4.81864486587309 1.11217831679872e-05 yes 3343 7.22682806525454e-07 1094 3983547 SGTC_3271 9137798 49.47 µM -5.02211769228191 4.9269023955069e-06 yes 3344 2.5552425227707e-07 1094 6498326 SGTC_778 3456-2434 196 µM -15.360053001172 5.31680516732124e-42 yes 3345 1.51663277135074e-53 1095 5539063