SGTCid condition conc unit WHI4|YDL224C.score WHI4|YDL224C.strain.pval WHI4|YDL224C.strain.significant WHI4|YDL224C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2412 st077135 33.4 µM 5.52434738112559 1.63079008026772e-10 yes 1 1.65356281675723e-08 4 13258915 SGTC_1718 roemerine 11.9335 µM 5.27032902728071 9.89328085808176e-10 yes 2 6.80897115748494e-08 19 235224 An aporphine alkaloid with mutagenic activity. SGTC_835 0312-0010 67.2 µM 4.64547868365338 5.93783653097062e-08 yes 3 1.69644403984408e-06 6 1626196 SGTC_2297 7971671 152.32 µM 4.61523466183487 7.15136656815212e-08 yes 4 1.96325702306304e-06 12 909016 SGTC_2799 7812892 81.82 µM 4.19108582651316 8.62034815347205e-07 yes 5 1.38811304009488e-05 26 20205235 SGTC_2309 7664088 163.95 µM 4.16327305942798 1.00708912922126e-06 yes 6 1.56858909953482e-05 19 704922 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 3.89985357046175 4.19179956365679e-06 yes 7 4.81254413540391e-05 33 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1611 st001856 99.4 µM 3.76573946575695 8.38663854894581e-06 yes 8 8.30284405097402e-05 21 647478 SGTC_608 k048-0125 159 µM 3.75908019136399 8.67551162842876e-06 yes 9 8.52695873646643e-05 37 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_549 1661-1316 519 µM 3.66090416033087 1.42036874263125e-05 yes 10 0.000125663382273824 23 2857282 SGTC_2814 7977482 42.97 µM 3.61822022151576 1.75348255183412e-05 yes 11 0.000148317970197075 63 6456762 SGTC_2313 7726885 200 µM 3.38493288945776 5.33393301058561e-05 yes 12 0.000355978294419328 55 726423 SGTC_1521 st012942 49.4 µM 3.34071249470188 6.53742697755566e-05 yes 13 0.000417818535445145 58 24207259 SGTC_1739 st037196 92.5 µM 3.33219240055206 6.79694224513748e-05 yes 14 0.000430823319769805 45 612214 SGTC_299 1273-0059 1.44 µM 3.06360587187882 0.000221730597105314 yes 15 0.00109343404690033 54 2848077 SGTC_2257 7960413 200 µM 2.98682789095724 0.000305990585231718 yes 16 0.00140944184569496 118 2974689 YIL048W NEO1 SGTC_532 1548-0774 215 µM 2.91718049844584 0.000407335158072553 yes 17 0.00176605654264256 60 5932993 SGTC_1261 0712-0010 12.7 µM 2.90770193196806 0.000423317574692952 yes 18 0.00182047595465513 78 2840123 SGTC_941 3237-0776 460 µM 2.87581413923278 0.000481454652756998 yes 19 0.00201493462118361 67 760008 SGTC_1908 st060353 56.5 µM 2.87548106585189 0.000482099167805556 yes 20 0.00201706170036465 93 4227716 SGTC_1913 st060213 96.1 µM 2.82729691124384 0.000584226898931596 yes 21 0.00234713904020007 114 688959 SGTC_2315 7733312 200 µM 2.80478047193155 0.000638504776286253 yes 22 0.00251754300039673 75 726316 SGTC_292 k038-0015 474 µM 2.80012477593357 0.000650293134537283 yes 23 0.00255414284507984 45 46368540 SGTC_1450 4112-4260 37.6 µM 2.67449646780808 0.00105506173775198 no 24 0.00374207823107493 93 1633175 SGTC_2791 5663188 71.43 µM 2.65306288627661 0.0011437315688703 no 25 0.00398825042358901 93 54690634 SGTC_855 0428-0020 25 µM 2.62839278173167 0.0012542104632483 no 26 0.00428946974376826 75 6812414 SGTC_1426 4048-4480 71.7 µM 2.55111619156874 0.00166644913902424 no 27 0.00536892604467145 100 14224343 SGTC_1570 verbenone 133 µM 2.53399265884271 0.00177307482111014 no 28 0.00563855471140133 102 29025 A natural terpanoid with antifungal properties. SGTC_3064 1327-0027 10 µM 2.51756727132142 0.00188114843810639 no 29 0.00590842006909334 46 16000455 YPR107C YTH1 SGTC_3054 9094397 49.47 µM 2.51733751693042 0.00188270171578486 no 30 0.00591227475325203 143 2598354 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 2.51674541508173 0.00188671005425409 no 31 0.00592221897183862 309 16725076 SGTC_3069 9117009 49.47 µM 2.47881699994509 0.00216022220660905 no 32 0.00659094591044438 57 41904981 SGTC_426 0988-0037 14.6 µM 2.46803336939334 0.00224429667059158 no 33 0.00679288270806947 144 5383008 SGTC_1010 4112-3296 15.2 µM 2.42910897673848 0.0025730062486566 no 34 0.00756799102472025 129 704384 SGTC_1270 0831-1170 17.3 µM 2.41879313182441 0.00266712543767029 no 35 0.00778604662151144 122 6764716 SGTC_537 1334-0398 209 µM 2.41582355427048 0.00269478958300265 no 36 0.00784983355835215 137 5846986 SGTC_1435 4092-0789 56.7 µM 2.38485435717451 0.0029991184242126 no 37 0.00854294204302382 108 2248285 SGTC_2322 7413319 38.22 µM 2.38171918787626 0.00303159177389737 no 38 0.00861601613739087 321 1840400 SGTC_738 1315-0003 72.4 µM 2.35975368364746 0.00326813002554963 no 39 0.00914353637868522 140 6251474 SGTC_1388 3346-4487 254 µM 2.35155325164876 0.00336060817902748 no 40 0.00934760671044188 147 3345614 SGTC_2096 5468907 200 µM 2.33458349662658 0.00355948693586569 no 41 0.00978259476029272 111 759785 SGTC_1837 st055472 66.5 µM 2.32946025311021 0.00362157205140064 no 42 0.00991734814462045 138 676091 SGTC_862 0452-0056 10.2 µM 2.32399381245435 0.00368888619748272 no 43 0.0100629128357622 132 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_685 1278-0033 54.9 µM 2.32104309931048 0.0037256860212845 no 44 0.0101422589309459 158 3590572 SGTC_3018 9082602 49.47 µM 2.30070502002903 0.00398841475572747 no 45 0.0107041550776616 156 17332089 SGTC_500 h-89 112 µM 2.29626389696866 0.00404794660920193 no 46 0.0108303985229927 159 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2603 homopterocarpin 100 µM 2.28808992355961 0.0041595988652203 no 47 0.0110661424655219 204 101795 A weak amylase inhibitor. SGTC_559 1550-0661 158 µM 2.26733336967459 0.00445560123208617 no 48 0.0116849342221385 135 5830875 SGTC_1020 4335-0961 93.3 µM 2.26305686277581 0.00451887490689777 no 49 0.0118160921256578 139 669075 SGTC_1610 st001799 48.1 µM 2.22405099811055 0.00513406204103777 no 50 0.0130725066205139 127 621897 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 2.22217089979656 0.00516551367833454 no 51 0.0131358791355626 177 5377381 SGTC_2104 5389443 200 µM 2.22041278280762 0.00519507975081291 no 52 0.0131953800614758 183 2244536 SGTC_1169 aniline yellow 25.8 µM 2.2178606380443 0.00523826686907854 no 53 0.0132821680325885 119 6051 A DNA damaging agent. SGTC_3084 9116877 49.47 µM 2.2001839360715 0.00554625819633908 no 54 0.013896923776324 97 27241325 SGTC_2448 5185112 27.17 µM 2.17502962951576 0.00601225776580716 no 55 0.0148139480508008 147 5718189 SGTC_1176 0848-0131 83.3 µM 2.16406754663421 0.00622597208248046 no 56 0.0152295828863099 199 6769040 SGTC_1101 ebselen 5.29 µM 2.11788563048031 0.00720198479334931 no 57 0.0170923774276051 190 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_3048 9093155 49.47 µM 2.10991449426569 0.00738346526518382 no 58 0.0174328607810582 129 25236002 SGTC_822 1487-0950 154 µM 2.09777648270046 0.00766755660442407 no 59 0.0179624474532979 186 1958375 SGTC_2226 7298446 200 µM 2.0938684632025 0.00776104996223837 no 60 0.0181358496458862 118 3283010 SGTC_2858 9025781 8.96 µM 2.06369153481608 0.00851739488180461 no 61 0.0195234862424088 336 4894980 YPL153C RAD53 SGTC_968 1309-0633 340 µM 2.06208515948029 0.00855941059723623 no 62 0.0195998145005987 190 3761976 SGTC_2588 indole-3-carbinol 100 µM 2.04929281860952 0.00890054166195966 no 63 0.0202167452336457 267 3712 Induces cell cycle arrest. SGTC_337 1315-0038 354 µM 2.03247871246678 0.00936700487017098 no 64 0.0210526083487911 193 1626437 SGTC_669 0108-0021 26.2 µM 2.01565839630337 0.00985489875096879 no 65 0.0219178544243246 347 17201 SGTC_1996 st072960 66.8 µM 1.99598055378221 0.0104537206054688 no 66 0.0229680197637709 213 1719405 SGTC_2435 5706476 10.6 µM 1.99173626991892 0.0105869601739029 no 67 0.0232000009791417 251 5725375 SGTC_1276 0871-0068 94.2 µM 1.9887493905259 0.0106816110589653 no 68 0.0233644357145072 189 3414906 SGTC_2843 9000894 45.46 µM 1.97841038090623 0.0110149559458637 no 69 0.0239412147953683 122 2242070 SGTC_1716 st033144 30.6155 µM 1.97614895791411 0.0110890620881074 no 70 0.0240689544415012 229 674617 SGTC_2856 9022925 19.48 µM 1.97223083391647 0.011218484549073 no 71 0.0242916306404891 242 4944862 SGTC_182 3448-4371 550.524 µM 1.96302814356369 0.0115276407184522 no 72 0.0248214519761364 222 3491403 SGTC_2812 7970281 58.44 µM 1.94944042446464 0.0119976277114441 no 73 0.0256214254601341 274 2233435 SGTC_1825 st052143 62.6 µM 1.94653268430042 0.0121003350722154 no 74 0.0257953928950249 192 674173 SGTC_2636 apigenin dimethyl ether 100 µM 1.94477656371671 0.0121627333378826 no 75 0.0259009379906374 292 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2473 5854593 8.94 µM 1.9434062113402 0.0122116180768744 no 76 0.0259835486910948 186 2872951 SGTC_418 lividomycin a 100 µM 1.94218264966276 0.0122554101326955 no 77 0.026057496372309 210 72394 An antibiotic. SGTC_1642 st009582 77.7 µM 1.94148162729161 0.012280561437103 no 78 0.0260999429078296 215 6739311 SGTC_1420 4'-methoxyflavone 42 µM 1.93283849936394 0.0125943535885 no 79 0.0266280480010372 207 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2084 5306078 60.6385 µM 1.92691712531528 0.0128133165677327 no 80 0.0269949794582425 247 679340 SGTC_1178 0988-0033 191 µM 1.90673778461731 0.0135844289982884 no 81 0.0282772757337429 295 5392207 SGTC_2437 5741531 144.16 µM 1.89430658291582 0.0140791343326485 no 82 0.0290921638774771 270 2262990 SGTC_958 1222-0007 33 µM 1.89014497569818 0.0142481802352252 no 83 0.0293692866854599 278 7312461 SGTC_3042 9091578 49.47 µM 1.89014342645326 0.0142482434902119 no 84 0.0293693902569253 169 25236497 SGTC_2306 7482397 179.52 µM 1.84979863156811 0.015979709215747 no 85 0.0321712890896041 263 891448 SGTC_784 4579-0127 173 µM 1.84545858082099 0.0161762936917 no 86 0.0324854291528893 255 1948547 SGTC_366 0181-0206 4.31 µM 1.84351227537767 0.0162651231921375 no 87 0.0326271255625406 322 274874 SGTC_602 3130-1533 38.1 µM 1.84315792209943 0.0162813407775859 no 88 0.0326529782281208 305 720941 SGTC_979 1426-2828 121 µM 1.84202373798404 0.0163333418000635 no 89 0.0327358388500208 307 747872 SGTC_732 3970-1727 52.7 µM 1.83784072896126 0.0165263593424828 no 90 0.0330429390327415 230 1275699 SGTC_1345 1488-0192 31.4 µM 1.8373867385655 0.0165474249007041 no 91 0.033076411573139 266 658348 SGTC_130 0136-0219 337.655 µM 1.81837770039891 0.0174503247171038 no 92 0.034503212136041 283 234244 SGTC_3230 9131665 49.47 µM 1.8172794995533 0.017503748744552 no 93 0.0345871636735549 117 15943720 SGTC_609 0986-0026 86.3 µM 1.79467238689643 0.0186349353049098 no 94 0.0363529562598916 321 2848610 SGTC_1451 4152-0210 104 µM 1.77839754909248 0.0194872894206998 no 95 0.0376692924721243 313 659563 SGTC_3153 9100258 49.47 µM 1.77773184561259 0.0195228476790901 no 96 0.0377239533815776 307 25236848 SGTC_3188 9110789 49.47 µM 1.76546440283026 0.020188037704101 no 97 0.0387428738924889 290 849217 SGTC_2583 asiatic acid 100 µM 1.76050728003013 0.0204622335130672 no 98 0.0391609171263624 288 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_734 2023-0417 80 µM 1.7578630095004 0.0206097836231372 no 99 0.0393854105479802 317 3935732 SGTC_946 3434-1334 87.4 µM 1.74442808441005 0.0213734458923819 no 100 0.0405422356957272 296 4047976 SGTC_266 formosanin C 406 nM 1.74197171627222 0.0215156257740509 no 101 0.0407566967602172 348 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2481 5478948 45.16 µM 1.74186671531362 0.0215217212297081 no 102 0.0407658846810664 324 77792 SGTC_561 1550-0330 72.9 µM 1.73641950141534 0.0218399477374395 no 103 0.0412448432696793 281 6812934 SGTC_1885 st057546 99.9 µM 1.73378551004721 0.0219952454898467 no 104 0.0414780737849724 334 702008 SGTC_3061 glucosamine 200 µM 1.7319689155332 0.022102892612472 no 105 0.041639548554727 265 91431 and experimental redox chemotherapeutic SGTC_780 0109-0199 192 µM 1.72773746605969 0.0223553636338536 no 106 0.0420176516135449 350 610414 SGTC_2347 9049783 174.81 µM 1.7266104468046 0.0224230164454672 no 107 0.0421188242402355 360 6467988 YPL169C MEX67 SGTC_1106 tegaserod maleate 11.7 µM 1.72591113068203 0.0224650818052406 no 108 0.0421817009764322 343 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1496 4469-0713 57.4 µM 1.72187596841668 0.0227091073718494 no 109 0.0425459945683788 308 746691 SGTC_2066 5222451 176 µM 1.71761102745083 0.0229694534558571 no 110 0.0429337937836849 388 2281147 SGTC_2160 5660466 132.927 µM 1.70001072991976 0.0240705796212278 no 111 0.0445644536286933 300 2859134 SGTC_1498 4478-3555 97.6 µM 1.69986086487213 0.0240801427769583 no 112 0.0445785498365878 239 3437919 SGTC_1004 4084-0029 199 µM 1.6987626701154 0.0241503179843567 no 113 0.0446819549383065 333 716894 YLR208W SEC13 SGTC_1132 3456-3614 2.5 µM 1.6978876973076 0.0242063520812641 no 114 0.0447644798428599 424 3125502 SGTC_2253 7938677 135.83 µM 1.69031564482982 0.0246958502140971 no 115 0.0454837918006995 303 2301972 SGTC_737 1950-0117 57.9 µM 1.68667539649252 0.0249341153395808 no 116 0.0458328927418389 330 5393513 SGTC_1175 0741-0056 27.6 µM 1.68317006864748 0.0251653682466584 no 117 0.0461710866529214 369 765927 SGTC_3149 9097855 49.47 µM 1.6830271412022 0.0251748354448775 no 118 0.0461849186997971 303 25236625 YMR079W SEC14 SGTC_3067 9117431 49.47 µM 1.67627405384152 0.025625559155536 no 119 0.0468422623415923 279 17150885 SGTC_2345 9052315 157.45 µM 1.6758306114742 0.025655390877063 no 120 0.0468856881363742 338 6469265 SGTC_3012 9080433 71.4286 µM 1.67432366558382 0.0257569850783297 no 121 0.0470335029483913 324 17688859 SGTC_1445 4239-0156 97.7 µM 1.67010829196488 0.0260429638857021 no 122 0.0474489699380024 381 4008346 SGTC_546 peri-Naphthalide 147 µM 1.66957057895901 0.0260796336104936 no 123 0.0475021777160579 324 223824 A penicillin ester. SGTC_2697 mebhydrolin 72.4 µM 1.66783744447434 0.0261981199832877 no 124 0.0476740002285164 396 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_329 k048-0121 21.3 µM 1.66763135245589 0.0262122394362682 no 125 0.047694465210275 328 6832902 SGTC_896 0964-0007 44.5 µM 1.66742378250219 0.0262264665737137 no 126 0.0477150840619052 303 6756758 SGTC_827 3253-0474 693 µM 1.66443525428786 0.026432021153488 no 127 0.0480127398830776 353 5402065 SGTC_788 1182-0090 188 µM 1.66082777214643 0.0266819399189293 no 128 0.0483740208615727 468 5715185 SGTC_2316 5844804 197.44 µM 1.64653363751193 0.0276916912442826 no 129 0.0498269702992368 455 776813 SGTC_1525 8-methoxypsoralen 92.5 µM 1.64631118090163 0.0277076540400751 no 130 0.0498498543493948 399 4114 Related to psoralen; DNA damaging agent. SGTC_1449 4112-4002 201 µM 1.64589724858361 0.0277373769476042 no 131 0.0498924577643583 336 2059539 SGTC_1251 0490-5699 265 µM 1.64313767384652 0.0279362112482186 no 132 0.0501772258269778 402 3883818 SGTC_427 1354-0053 47.3 µM 1.63450041773706 0.0285662347882264 no 133 0.0510769093008193 370 6813657 SGTC_159 3970-0959 50 µM 1.63366735904775 0.0286276202669667 no 134 0.051164357843172 579 6615653 SGTC_588 3970-1144 52.9 µM 1.62753667030871 0.0290827539933629 no 135 0.0518115834804819 373 1888707 SGTC_1129 3453-1384 223 µM 1.62104286997466 0.0295713850882428 no 136 0.0525042224685301 406 1084452 SGTC_943 3253-1379 105 µM 1.61573037105018 0.0299761782713135 no 137 0.0530763107712811 355 668464 SGTC_346 4513-0042 7.16 µM 1.61384889673892 0.0301206372223357 no 138 0.0532801027740935 390 2827372 SGTC_2462 5162487 171.77 µM 1.6136324028266 0.0301372965147542 no 139 0.0533035920613549 365 2259986 SGTC_1490 4089-0339 670 nM 1.61081495158796 0.0303547979034382 no 140 0.0536100306408827 281 742542 SGTC_1181 1222-0449 220 µM 1.60754100869144 0.0306091717540865 no 141 0.0539678705148999 368 658318 SGTC_3013 9080133 71.4286 µM 1.59911704298016 0.0312718087421556 no 142 0.0548972992293038 416 17050193 SGTC_1314 1222-0010 41.1 µM 1.59701757517907 0.0314387889846658 no 143 0.0551308948149069 341 3526027 SGTC_3354 9151612 71.43 µM 1.59617452168533 0.0315060479810561 no 144 0.0552249171587165 388 27261949 SGTC_2456 5770359 74.46 µM 1.58754826496605 0.0322011116423535 no 145 0.0561942623791806 355 3118787 SGTC_1733 st037357 54.9 µM 1.58474267834951 0.0324298822763501 no 146 0.0565124054417376 421 1272339 YGL099W LSG1 SGTC_319 1348-1596 45.5 µM 1.58427248544132 0.0324683532083018 no 147 0.056565862163934 396 5380505 SGTC_1889 st059080 5.18 µM 1.57906062640835 0.0328973116568583 no 148 0.0571610758697995 401 176925 Isolated from Daphnopsis sellowiana. SGTC_2119 5528445 120.635 µM 1.57879488097202 0.0329193082211141 no 149 0.0571915565756936 364 791935 SGTC_746 1095-0025 46.6 µM 1.57724750406092 0.0330476302673615 no 150 0.0573692931677471 397 6749286 SGTC_548 1436-0017 110 µM 1.57609063770302 0.0331438367877362 no 151 0.0575024581840448 456 9677137 SGTC_1230 0170-0365 3.77 µM 1.55557033199366 0.0348890170648943 no 152 0.0599051490491105 546 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_219 mitoxanthrone 164.414 µM 1.54521697454273 0.0357977622525931 no 153 0.0611468949261049 409 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_729 4092-0585 94.1 µM 1.54485436634797 0.0358299377154799 no 154 0.0611907467696928 361 2169061 SGTC_1109 tnp00067 928.257 nM 1.53920911062812 0.0363339236355833 no 155 0.0618766270753532 375 676295 SGTC_646 4092-0839 27.3 µM 1.53843941992619 0.0364030858959013 no 156 0.0619706050261923 385 877796 SGTC_2321 7390090 138.78 µM 1.53317144949562 0.0368793483881595 no 157 0.0626168084301618 357 649046 SGTC_699 0375-0592 111 µM 1.53159874036356 0.0370225161136632 no 158 0.0628107417793699 372 762578 SGTC_409 arachidonic acid 100 µM 1.52902626997229 0.0372576736975963 no 159 0.0631289658034475 399 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1654 st012436 41.8 µM 1.52878185178688 0.0372800800715523 no 160 0.0631592664269321 352 4323132 SGTC_2829 7992743 58.44 µM 1.52616963011829 0.0375202366327934 no 161 0.0634838123769073 421 16462845 SGTC_1343 1487-0095 224 µM 1.52559247043267 0.0375734682826225 no 162 0.0635556942395751 378 4560101 YGL055W OLE1 SGTC_727 3032-0951 202 µM 1.52390512022278 0.0377294469643284 no 163 0.0637662071185093 383 3652836 SGTC_649 1123-0311 367 µM 1.52347172441052 0.0377695952782443 no 164 0.0638203647935197 473 693629 YIL048W NEO1 SGTC_2285 7945142 200 µM 1.52149376707603 0.0379532694578619 no 165 0.0640679871347852 406 2970608 SGTC_1483 3453-0561 55.9 µM 1.5101734350767 0.0390185496029697 no 166 0.06549958762739 457 4546991 SGTC_1284 0929-0043 16 µM 1.50836270686293 0.0391911821922593 no 167 0.065730861119271 447 1239883 SGTC_1924 st058459 75.1 µM 1.50816554644765 0.0392100166942628 no 168 0.0657560814090144 375 688683 SGTC_606 k015-0008 38.6 µM 1.50811599112436 0.0392147518141972 no 169 0.0657624215871523 445 1970475 SGTC_2859 9028643 45.46 µM 1.49999398032259 0.0399971393582776 no 170 0.0668079809265228 374 17151580 SGTC_1005 4092-0690 4.4 µM 1.49917699616238 0.0400765361476415 no 171 0.066913860557301 413 1529343 SGTC_705 1124-0212 310 µM 1.49427173187901 0.0405559398555523 no 172 0.0675523052494486 441 9554485 SGTC_186 3455-3465 67.277 µM 1.49116549819348 0.0408619198147792 no 173 0.0679590247526079 300 755278 SGTC_1414 3917-0015 5.4 µM 1.47897509076039 0.0420808810720329 no 174 0.0695734861603098 387 6618702 SGTC_1710 st031758 61.5 µM 1.4777319512216 0.0422068235196579 no 175 0.0697397693541023 387 5394341 SGTC_1479 0549-0158 134 µM 1.47418727861901 0.0425676096840368 no 176 0.0702155870415567 477 5440202 SGTC_1882 5615643 20 µM 1.4737825015972 0.042608967135635 no 177 0.0702700805780795 385 2253075 SGTC_2365 9042475 200 µM 1.47247028875604 0.042743263832741 no 178 0.0704469622600317 462 6464479 SGTC_169 k015-0017 16.025 µM 1.47021048932687 0.0429753418673564 no 179 0.0707523773446672 402 1840002 SGTC_1780 st038448 24.544 µM 1.46659649653565 0.0433486086844379 no 180 0.071242926830984 426 728868 YDL195W SEC31 SGTC_2944 9067346 25.62 µM 1.459952038166 0.0440417012849018 no 181 0.0721516279458983 460 6473075 SGTC_828 2074-0507 139 µM 1.45968276410973 0.0440699769518264 no 182 0.0721886405203668 470 X828 SGTC_733 4069-0007 56.1 µM 1.45739430391001 0.0443108725733734 no 183 0.0725037842608425 528 5717425 YNL287W SEC21 SGTC_846 0335-0850 148 µM 1.45345026215753 0.0447285332976787 no 184 0.0730493899220578 400 6819598 SGTC_2147 5545932 89.7195 µM 1.45221459061279 0.044860037036096 no 185 0.0732209734806534 416 797404 SGTC_1273 0849-0096 14.1 µM 1.45083575216845 0.045007144281484 no 186 0.0734128008039645 458 5286025 SGTC_2640 pentamidine 10.38 µM 1.45083265734443 0.0450074749021443 no 187 0.0734132317952392 499 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1410 3909-8106 77.9 µM 1.44617049143403 0.0455077588742187 no 188 0.0740646940523693 430 1039210 SGTC_1813 st051246 8.6015 µM 1.44294754733426 0.0458562108738696 no 189 0.0745176238287374 403 5291959 SGTC_2794 7785382 27.27 µM 1.44040205671817 0.0461329319925472 no 190 0.0748768410675131 539 2205081 SGTC_1698 5-fluorocytosine 1.055 µM 1.43563319723797 0.046654965328155 no 191 0.0755533716026813 420 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2616 abietic acid 100 µM 1.43420626223209 0.0468120858243284 no 192 0.0757567052701327 495 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2038 4100038 30.985 µM 1.43395495810954 0.0468398009495989 no 193 0.0757925584305792 461 3596803 SGTC_2650 prasterone 100 µM 1.43387951395828 0.0468481238911261 no 194 0.0758033244498614 352 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.43262337016874 0.0469868750975839 no 195 0.0759827496682743 432 756377 SGTC_2413 inermin 26.06 µM 1.43004853775664 0.0472723160611722 no 196 0.0763515443895162 496 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_3343 9148379 18.9835 µM 1.42653036214717 0.0476645791729666 no 197 0.0768576546077718 440 1955036 SGTC_1253 0550-0034 176 µM 1.42314103018292 0.0480449379122581 no 198 0.0773476380992154 446 5969915 SGTC_3318 9139014 38.6185 µM 1.42055215798809 0.0483371004080261 no 199 0.0777234976345638 429 16643984 SGTC_181 1447-1644 8.07 µM 1.41870530502511 0.0485463908555439 no 200 0.077992474967508 460 534600 SGTC_2970 9090938 41.86 µM 1.41579834101153 0.0488772831234111 no 201 0.0784172777322536 562 17217104 SGTC_164 4100-3994 89.624 µM 1.41550110822155 0.0489112176847433 no 202 0.0784608118538672 531 4615967 SGTC_764 1951-2361 146 µM 1.41331828998569 0.0491610034323145 no 203 0.0787810792810077 500 5438930 SGTC_39 0986-0283 58.349 µM 1.41269474076937 0.0492325446201043 no 204 0.0788727493087181 542 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1644 st010134 20.9 µM 1.40881054987549 0.0496800602301168 no 205 0.0794455973901191 453 3818134 SGTC_3157 9099274 49.47 µM 1.40770234259948 0.0498083353089186 no 206 0.0796096139389017 436 17217662 SGTC_2103 5378138 10 µM 1.4052446748517 0.0500937532215793 no 207 0.0799742668442201 535 244142 SGTC_336 4111-0029 111 µM 1.40355226843458 0.050291055597384 no 208 0.0802261085553769 399 3131175 SGTC_207 4185-0010 4.486 µM 1.40208970932275 0.0504620606000329 no 209 0.0804442298240149 561 3761753 SGTC_389 tpck 16.7 µM 1.39754082696441 0.0509968867065339 no 210 0.0811254991730444 465 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_3265 9137266 49.47 µM 1.39714701022764 0.0510434003698328 no 211 0.0811846838175877 413 17224265 SGTC_935 2996-0153 430 µM 1.39491315647303 0.0513078799599561 no 212 0.081521014611483 464 23738523 SGTC_2118 5526350 200 µM 1.39490923451012 0.0513083452619392 no 213 0.0815216060279172 496 743594 SGTC_2215 7188065 200 µM 1.39480246248478 0.0513210139929816 no 214 0.0815377080684539 394 940217 SGTC_2125 5246583 200 µM 1.39390112660725 0.0514280586291431 no 215 0.0816737320229843 558 835267 SGTC_3297 9117502 71.43 µM 1.38803908283538 0.0521285872769539 no 216 0.0825625722324115 451 7453720 SGTC_394 menadione 8.33 µM 1.38780915171476 0.0521562183311217 no 217 0.0825975836624142 495 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_38 0929-0051 58.268 µM 1.3867031618234 0.0522892888387611 no 218 0.0827661480390283 538 1379719 SGTC_259 usnic acid 108.925 µM 1.3826482057166 0.052779480707717 no 219 0.0833863802009632 501 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_779 1360-0071 233 µM 1.38080540319764 0.0530034533473052 no 220 0.0836694008654435 534 7566 SGTC_3190 9110366 49.47 µM 1.38062220905268 0.0530257597344836 no 221 0.0836975755158736 412 17123768 SGTC_222 nsc-310342 10.666 µM 1.38031000820405 0.0530637916017959 no 222 0.0837456073911245 347 432556 SGTC_2847 9005661 71.43 µM 1.38019892729657 0.0530773285373112 no 223 0.0837627021018509 333 2991449 SGTC_2476 5806916 10.51 µM 1.38000002282922 0.0531015749804498 no 224 0.0837933189004949 456 2870194 SGTC_2898 9056270 58.44 µM 1.37854718025667 0.0532789428552133 no 225 0.0840172058026858 412 19154699 SGTC_1587 estradiol valerate 56.1 µM 1.37692122659825 0.0534780012191279 no 226 0.0842683018657857 506 13791 A steroid. SGTC_2891 9063876 19.48 µM 1.37563892768509 0.0536354026938038 no 227 0.0844667242227038 412 6472478 SGTC_51 1013-0126 23.419 µM 1.3752482569849 0.0536834301693751 no 228 0.0845272460414682 466 1627850 SGTC_290 2043-6722 48.1 µM 1.36935470885223 0.0544120998103776 no 229 0.0854442121932936 499 773758 YLR208W SEC13 SGTC_659 k018-0002 107 µM 1.36556724747296 0.0548844905761624 no 230 0.086037416266204 507 6797879 YHR007C ERG11 SGTC_1736 st036774 51 µM 1.36105346044517 0.0554516989885281 no 231 0.0867483977670622 524 1272247 SGTC_603 3794-0023 45.9 µM 1.35975975823284 0.0556151177906794 no 232 0.0869529803604839 464 3802260 SGTC_766 1391-0721 126 µM 1.354333186068 0.0563047404144541 no 233 0.0878150515657785 500 1020919 YIL115C NUP159 SGTC_844 0330-0132 15.3 µM 1.35295603052146 0.0564808209479869 no 234 0.0880348388354656 509 2828079 SGTC_2941 9056145 11.23 µM 1.35295374374349 0.0564811136916146 no 235 0.0880352041347999 405 2119517 SGTC_3162 9099653 49.47 µM 1.34990418561386 0.0568725704031094 no 236 0.0885233594613357 442 25237511 SGTC_2915 7971052 15.16 µM 1.3470777277959 0.0572372937164095 no 237 0.0889776002192704 357 5741558 SGTC_2518 prenyletin 46.28 µM 1.34666946682162 0.0572901271138949 no 238 0.0890433550961666 407 3873459 A coumarin with calcium channel inhibitory activity. SGTC_542 3381-0244 89.3 µM 1.33986286104342 0.0581766409723316 no 239 0.0901449671434847 592 1112843 SGTC_1832 st054113 55 µM 1.3369937398374 0.0585535383190946 no 240 0.0906123401380303 474 1251267 SGTC_1907 st060210 83.7 µM 1.33639672944104 0.0586322040324695 no 241 0.0907098173795952 571 688793 SGTC_1755 st041960 45.185 µM 1.33624208276212 0.0586525947406264 no 242 0.0907350800976452 502 2257073 SGTC_2107 5363541 170.161 µM 1.33066753728306 0.0593913418594874 no 243 0.0916492145589776 521 244052 SGTC_3024 9090631 49.47 µM 1.32405978142189 0.060276437181547 no 244 0.092741595649441 474 25236383 SGTC_1655 st012546 55.1 µM 1.32153522315746 0.0606173098058041 no 245 0.0931614829870485 490 720985 YLR208W SEC13 SGTC_3319 9138450 16.7555 µM 1.32145944146305 0.0606275653170693 no 246 0.0931741087654926 498 2029690 SGTC_3093 9117344 49.47 µM 1.31886731655132 0.0609791745687747 no 247 0.0936067372034634 508 24824913 SGTC_1390 3413-2614 145 µM 1.31879797374523 0.0609886024324599 no 248 0.0936183309296048 561 3421432 SGTC_1967 st070177 51.4 µM 1.31740585609977 0.0611781162280575 no 249 0.0938513095170626 495 5729214 SGTC_1338 1486-1223 76 µM 1.30276466380312 0.0631992492058273 no 250 0.0963275590163904 585 3444526 SGTC_683 panaxydol 45 µM 1.30009896706907 0.0635727660125195 no 251 0.0967835258293094 579 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_3004 9076122 71.4286 µM 1.29816279041154 0.0638451379357107 no 252 0.0971157007057698 550 44782551 SGTC_73 0327-0325 16.231 µM 1.29814499738961 0.0638476451737296 no 253 0.0971187571922727 633 53298 SGTC_990 3985-0011 41.3 µM 1.29782535148528 0.0638926999430803 no 254 0.0971736780142352 482 5399565 YGL099W LSG1 SGTC_12 0849-0099 9.267 µM 1.29771145265219 0.0639087601993048 no 255 0.0971932533555863 528 6071388 SGTC_1317 1273-0028 910 nM 1.29663975397963 0.0640600283967895 no 256 0.0973775836892468 547 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_212 3807-4682 38.772 µM 1.28981989905767 0.0650291685680615 no 257 0.0985565986101474 718 3125501 YBL034C STU1 SGTC_2492 derrusnin 100 µM 1.28841976663595 0.0652295361353992 no 258 0.0987999408013986 491 1715307 Part of coumarin class of compounds. SGTC_429 1112-0049 25.5 µM 1.2866803633884 0.0654791222297625 no 259 0.0991028600721869 522 2836170 SGTC_1980 st071811 45.7 µM 1.28497264367448 0.0657248819569701 no 260 0.0994009218897726 539 4974850 SGTC_1037 k284-1091 78.7 µM 1.28362271505291 0.0659196571305912 no 261 0.0996369989430354 496 3334711 SGTC_135 0933-0004 26.348 µM 1.28341317615229 0.065949930626165 no 262 0.099673680045929 547 21230617 YGL099W LSG1 SGTC_2485 5633444 17.78 µM 1.27686591641156 0.0669012950432995 no 263 0.100824794519585 562 5724239 SGTC_834 0312-0008 75.7 µM 1.27508973913292 0.0671612086040506 no 264 0.101138740388326 593 6385573 YIL048W NEO1 SGTC_2795 7780010 54.55 µM 1.27460846305791 0.0672317695069855 no 265 0.101223930249251 527 953673 SGTC_1969 st069479 40.1 µM 1.27148392501603 0.0676912593813646 no 266 0.101778271314094 501 3895485 SGTC_3277 9138724 49.47 µM 1.27037771077123 0.0678545178142465 no 267 0.101975059470303 452 15943418 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.26661605694404 0.0684119498072339 no 268 0.102646304097127 594 94937 An inhibitor of serotonin biosynthesis. SGTC_2986 9022445 71.43 µM 1.24643037550555 0.0714637643471558 no 269 0.106303217689237 574 6459286 SGTC_2048 5246248 200 µM 1.24304420727118 0.071985787814231 no 270 0.106925771777734 538 677046 SGTC_1008 4106-0037 6 µM 1.24261595565892 0.0720520163029319 no 271 0.107004693702305 552 2905394 SGTC_2894 9048625 32.47 µM 1.2339006690936 0.0734099934534357 no 272 0.108619960092786 584 4092861 SGTC_279 1273-0055 2.93 µM 1.22624169200541 0.0746194650325242 no 273 0.110053868118222 653 2847562 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.21834021261262 0.0758831089454892 no 274 0.111547357385956 624 688669 SGTC_1817 st052116 64.4 µM 1.21733902382983 0.0760443804123805 no 275 0.111737626255527 574 4361398 SGTC_2027 5150920 200 µM 1.21479320965167 0.076455635342789 no 276 0.112222485672307 608 786715 SGTC_356 1634-0012 32.5 µM 1.21181796177024 0.0769384034016026 no 277 0.112791035555581 656 735457 SGTC_1968 st069590 43.6 µM 1.21114747242201 0.0770475172288745 no 278 0.112919445020767 592 6384066 SGTC_1556 plumbagin 1.48 µM 1.20901350518935 0.0773955767702675 no 279 0.11332882846653 545 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1446 4239-0190 62 µM 1.20099037980614 0.0787148751574678 no 280 0.114877466541059 673 1340085 SGTC_1888 azatryptophan 97.5 µM 1.19628412404681 0.0794966482445118 no 281 0.11579285100326 573 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_716 1683-5115 658 µM 1.19423419425702 0.0798390008098676 no 282 0.116193185378396 717 723597 SGTC_293 4049-0273 38.5 µM 1.18701020005395 0.0810543493551069 no 283 0.117611798586305 598 1380311 SGTC_2635 hydroquinidine 100 µM 1.18430787707671 0.0815125530824988 no 284 0.118145605909805 635 442912 An experimental heart treatment. SGTC_2551 apiole 73.87 µM 1.18426854575158 0.08151923646271 no 285 0.118153387910482 468 10659 A possible DNA adduct former. SGTC_1975 st070967 30.8 µM 1.18165127684081 0.0819649054681313 no 286 0.118672049256414 714 261391 SGTC_1291 0993-0025 5.79 µM 1.179707811646 0.0822970250581409 no 287 0.11905822295992 648 4353356 SGTC_639 0833-0042 114 µM 1.178503814531 0.082503284432949 no 288 0.11929790625806 678 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_155 k072-0202 43.6 µM 1.17551115011962 0.0830176498397919 no 289 0.119895139472424 609 5857737 SGTC_1138 3761-0006 1.03 µM 1.17331969666906 0.0833958339162654 no 290 0.120333813247673 635 12061087 SGTC_1773 st048542 73.5835 µM 1.17159287587177 0.0836947463649647 no 291 0.120680274833537 648 3237138 SGTC_2335 9018011 154.17 µM 1.16556099559341 0.0847451811855543 no 292 0.121895992745561 684 6458208 SGTC_1854 st056233 32.9 µM 1.16435056381816 0.0849571603476051 no 293 0.122140986549026 635 5393174 SGTC_2658 polymyxin b sulfate 77.05 µM 1.16166362863818 0.0854291350348709 no 294 0.122686062587289 678 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_3314 9135860 59.4275 µM 1.15991797671793 0.0857368189445552 no 295 0.123041101439116 679 25252478 SGTC_503 tyrphostin 8 294 µM 1.15790266876714 0.086093062516291 no 296 0.123451879162283 638 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2247 cerulenin 830 nM 1.15728554452903 0.0862023719974079 no 297 0.123577858735479 655 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2362 9071156 126 µM 1.15625673995789 0.0863848319948202 no 298 0.123788078722696 650 653133 SGTC_1310 1188-0297 994 nM 1.15597261908094 0.0864352721011631 no 299 0.123846178432117 654 1588352 SGTC_1814 st052110 31.539 µM 1.15593816991509 0.0864413893735385 no 300 0.123853224218865 618 674163 SGTC_829 1635-0120 117 µM 1.15408600106932 0.0867707629562176 no 301 0.124232456022116 691 285054 SGTC_2541 muurolladie-3-one 83.07 µM 1.14895222604959 0.0876886101031057 no 302 0.125287840305436 639 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1494 4358-1428 177 µM 1.14799245668415 0.0878610041779364 no 303 0.125485838939272 691 1564571 SGTC_2135 5326629 150.42 µM 1.14497731883791 0.0884042285799259 no 304 0.126109276498942 602 5020077 SGTC_1219 1469-0211 33.1 µM 1.14279815048945 0.0887983952251252 no 305 0.126561203445694 646 6822282 SGTC_360 0957-0399 1.01 µM 1.14219447432168 0.088907818933027 no 306 0.126686596152564 700 6752301 YPR165W RHO1 SGTC_730 1436-0052 41.2 µM 1.14029648026262 0.0892525075896583 no 307 0.127081401851139 631 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_723 4182-0001 115 µM 1.13932043930141 0.0894301499396302 no 308 0.127284763185738 636 744821 YLR208W SEC13 SGTC_2968 9090663 33.37 µM 1.13840748285922 0.0895965486348569 no 309 0.127475185457145 672 25236811 SGTC_2525 harmine 47.85 µM 1.13711697144733 0.0898321544168438 no 310 0.12774469502894 617 5280953 A monoamine oxidase inhibitor SGTC_1795 st049545 62.3 µM 1.13663143518938 0.089920916806798 no 311 0.127846196567763 654 5291882 SGTC_334 1502-1024 68.5 µM 1.13356593156285 0.0904828363990191 no 312 0.128488335200651 694 3296216 SGTC_2055 5235184 200 µM 1.13310941181539 0.0905667409192201 no 313 0.12858415470778 664 2836034 SGTC_2619 obliquin 87.91 µM 1.13294513540972 0.0905969476788244 no 314 0.128618647020355 755 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1989 st071868 50.2 µM 1.1313108100625 0.0908978709808537 no 315 0.128962148009522 677 16414057 SGTC_2406 ethylparaben 405.7 µM 1.12983428257991 0.0911703765038014 no 316 0.129273029775182 576 8434 A possible steroid mimic. SGTC_2701 st077767 14.721 µM 1.12912745711987 0.0913010412858475 no 317 0.129422035051404 725 5721188 SGTC_1783 st039459 87.517 µM 1.12766245034907 0.0915723065797049 no 318 0.129731250738093 743 729761 SGTC_495 decylubiquinone 155 µM 1.12751633800281 0.0915993939237593 no 319 0.129762118377503 659 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2379 9035213 200 µM 1.1265549820856 0.0917777649720087 no 320 0.129965340887965 745 646551 SGTC_2713 st079149 53.4 µM 1.12511303326639 0.0920457879672426 no 321 0.130270569550165 715 3103253 SGTC_1293 1000-1278 195 µM 1.12477563763427 0.0921085851431273 no 322 0.130342060281774 711 678847 SGTC_1258 0671-0043 57.1 µM 1.12333454894237 0.0923771623587413 no 323 0.130647717938313 679 4298767 SGTC_2586 curcumin 80 µM 1.11961468274709 0.0930731156890686 no 324 0.131438997976739 782 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_26 0302-0163 425.158 µM 1.11932356097401 0.0931277450120805 no 325 0.131501063928276 697 3100915 SGTC_3009 9080819 71.4286 µM 1.11921157250921 0.093148766081496 no 326 0.131524944790562 681 17027216 SGTC_479 n-linoleoylglycine 10 µM 1.11870606462761 0.0932436973175629 no 327 0.131632778539639 653 6433346 An anti-infammatory. SGTC_185 k048-0037 25.491 µM 1.11787931089378 0.0933991105603779 no 328 0.13180927116173 717 6827589 SGTC_945 3381-0768 11.3 µM 1.11702748799678 0.0935594363580713 no 329 0.131991286154618 736 1126236 YIL048W NEO1 SGTC_2041 5107442 45.335 µM 1.11675352963549 0.0936110425839777 no 330 0.132049861588519 701 793005 SGTC_2020 4017018 200 µM 1.11512322801372 0.0939185813895383 no 331 0.132398809472683 678 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1590 st077108 57.8 µM 1.10766530406625 0.0953349492998622 no 332 0.134003194445816 689 5489485 SGTC_180 1486-1293 102.781 µM 1.10763132556804 0.0953414380983504 no 333 0.134010534505627 712 4140536 SGTC_959 1222-0044 107 µM 1.10530692839196 0.0957860953126059 no 334 0.134513308401625 700 6083612 SGTC_1238 0333-0287 48.8 µM 1.10455115960624 0.0959310020377383 no 335 0.134677062002823 682 7226 SGTC_2828 7998861 71.43 µM 1.10386372616257 0.096062946497028 no 336 0.134826128045666 609 2988188 SGTC_2977 9011197 71.43 µM 1.10227859712759 0.0963677011571906 no 337 0.135170285610131 627 2704722 SGTC_1012 4112-3522 18 µM 1.09777382813406 0.0972376593568242 no 338 0.136151631219942 708 3112398 SGTC_2676 harmalol 100 µM 1.09494004611251 0.0977878622830739 no 339 0.13677145162661 747 5459187 A monoamine oxidase inhibitor SGTC_3251 9135047 49.47 µM 1.09265272717617 0.0982336265435591 no 340 0.137273151401299 679 17682963 SGTC_3316 9136639 10.545 µM 1.08765210617409 0.0992133533282415 no 341 0.138374359250887 707 4903665 SGTC_1568 digitonin 820 nM 1.08671704048613 0.0993973425725173 no 342 0.138580940358144 761 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_352 k048-0007 5.11 µM 1.08495139275534 0.0997454421366742 no 343 0.138971592071906 773 6811911 SGTC_1039 k821-0043 94 µM 1.08419362646183 0.0998951094923774 no 344 0.139139478499558 737 15992768 SGTC_1677 st019204 53.9 µM 1.08287547274443 0.100155850365775 no 345 0.13943185000042 674 3945625 SGTC_397 arbidol 50 µM 1.08186212964789 0.100356634904033 no 346 0.139656897278213 764 131410 A RNA synthesis inhibitor. SGTC_1860 st056228 74.6 µM 1.08134992702641 0.100458234796679 no 347 0.139770743198781 691 688679 SGTC_3253 9135987 49.47 µM 1.0777723392716 0.101169974225694 no 348 0.140567683264174 661 4182430 SGTC_873 0591-4978 488 µM 1.07703149889546 0.101317818086966 no 349 0.140733096897919 786 3305145 SGTC_3071 9117417 49.47 µM 1.07661451258269 0.101401102063594 no 350 0.140826258996675 629 45595590 YGL055W OLE1 SGTC_2369 9071472 200 µM 1.07595530971705 0.101532865262572 no 351 0.140973621887598 736 17296037 SGTC_1225 1216-0074 20.6 µM 1.07590869015171 0.101542188422516 no 352 0.14098404751494 731 4241466 SGTC_133 0724-0033 378.92 µM 1.07559651832782 0.101604633809615 no 353 0.141053872604083 693 280309 SGTC_11 0438-0307 1.3 µM 1.07508230470603 0.101707555650819 no 354 0.141168940554752 721 4011476 SGTC_75 0159-0059 199.013 µM 1.0737044231825 0.10198371811281 no 355 0.141477589150609 699 5377270 SGTC_3182 9108849 49.47 µM 1.07352204104651 0.102020312981001 no 356 0.141518477407943 748 17133045 SGTC_1706 st031321 9.9705 µM 1.07318888835845 0.102087184538508 no 357 0.141593187590706 750 6103185 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.07299725804919 0.10212566368044 no 358 0.141636173189098 761 688751 SGTC_621 3584-0052 32.1 µM 1.07187790774749 0.102350638754529 no 359 0.141887437143625 768 2273927 SGTC_1201 1889-3372 45.9 µM 1.06759986459119 0.103213791589102 no 360 0.142850522373211 708 5392199 SGTC_2820 7989630 71.43 µM 1.06482035137803 0.103777421289778 no 361 0.14347861685372 623 2984098 SGTC_489 paxilline 115 µM 1.06436435137823 0.10387010176236 no 362 0.143581838216956 697 105008 A toxic potassium channel blocker. SGTC_372 0155-0182 15.9 µM 1.0614144566244 0.104471108608513 no 363 0.144250794922795 801 771486 SGTC_2771 fluoxetine 41.05 µM 1.06026444965346 0.104706090484394 no 364 0.144512153829468 706 3386 A selective serotonin reuptake inhibitor. SGTC_761 k216-0224 480 µM 1.05972100981698 0.10481726508153 no 365 0.144635770842166 807 1340404 SGTC_1625 st003711 30.1 µM 1.05915300105516 0.104933557216089 no 366 0.144765052695251 738 24207034 YER133W GLC7 SGTC_2896 9052656 71.43 µM 1.05677666494718 0.105421092813003 no 367 0.145306763252182 819 6469436 SGTC_2196 6573537 42.6665 µM 1.05536442916475 0.105711606030217 no 368 0.145629342348167 739 2903087 SGTC_1119 parthenolide 318.541 nM 1.05440357498053 0.105909595420843 no 369 0.14584909311064 822 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2447 5741742 33.78 µM 1.05329105043811 0.106139171959559 no 370 0.146103809688497 759 1776504 SGTC_2681 menadione 3.18 µM 1.05163523082574 0.106481526281892 no 371 0.146483468713465 745 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1139 k015-0024 46.9 µM 1.04811394242105 0.107212230602793 no 372 0.14729305666909 761 2766652 SGTC_3160 9100216 49.47 µM 1.04605665781897 0.107640808414305 no 373 0.147767437248107 758 17191039 SGTC_1381 2324-0066 62.1 µM 1.04446768831585 0.107972669727717 no 374 0.148134530513595 711 10885928 SGTC_3086 9117350 49.47 µM 1.04269740573662 0.108343265779751 no 375 0.148544229894848 701 2679265 SGTC_1791 st048313 56.1 µM 1.04254777277136 0.108374632279233 no 376 0.14857889438874 700 1204976 SGTC_102 gallobenzophenone 83.616 µM 1.04187821100133 0.108515067813159 no 377 0.148734073643649 756 70837 SGTC_188 3229-0966 278.469 µM 1.04011219557411 0.10888610414802 no 378 0.149143889155708 882 5722370 SGTC_410 α-linolenic acid 100 µM 1.0395178767064 0.1090111742443 no 379 0.149281974206162 793 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1344 1488-0097 29.1 µM 1.03910786414018 0.109097518585251 no 380 0.149377286962343 745 747966 SGTC_543 3844-1095 191 µM 1.03415052631367 0.110145373367072 no 381 0.150532899301321 813 4230703 SGTC_1035 k081-0041 55.2 µM 1.0327449866109 0.110443777981208 no 382 0.150861627405435 795 731709 SGTC_1618 st003135 44.5 µM 1.03240233702985 0.110516612359673 no 383 0.150941838799782 750 1270615 SGTC_1851 st056236 18.9 µM 1.03209011007829 0.110583010010974 no 384 0.151014953223798 794 5393171 SGTC_3287 9117173 37.0625 µM 1.03205498172231 0.110590482136355 no 385 0.151023180732536 735 2789709 SGTC_1828 st055811 49 µM 1.03123851880017 0.110764253294716 no 386 0.151214490792144 746 5877589 SGTC_32 0928-0142 34.1 µM 1.03119879301357 0.110772713285661 no 387 0.151223803277599 761 2244242 SGTC_3132 9126706 49.47 µM 1.03004996729991 0.111017567172297 no 388 0.151493275077108 738 850858 SGTC_1997 st073024 93.8 µM 1.0288637242392 0.111270802502076 no 389 0.151771858420236 776 686268 SGTC_254 nsc-64875 3.808 µM 1.02815130548055 0.111423085964506 no 390 0.151939329972003 793 56993 SGTC_2353 9059630 146.67 µM 1.02749642342968 0.111563202163324 no 391 0.152093384353093 777 4779114 SGTC_2444 5485484 36.41 µM 1.02516862806456 0.11206226927176 no 392 0.15264181408149 808 6790631 SGTC_1022 4477-0945 21.3 µM 1.02383994929751 0.112347845500873 no 393 0.152955438851356 767 4648966 SGTC_927 2425-1185 123 µM 1.02227218269332 0.112685477794756 no 394 0.153326047612852 774 730375 SGTC_2374 9071832 200 µM 1.02057944445491 0.113050836665807 no 395 0.15372686618315 753 17381698 SGTC_2935 9038016 29.96 µM 1.01940286421869 0.113305286046526 no 396 0.154005873469264 825 6463195 SGTC_257 daunorubicin 18.5 µM 1.01759737797038 0.113696537771343 no 397 0.154434666967809 781 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1941 st076221 61.8 µM 1.01525246360616 0.114206120733876 no 398 0.154992748923917 818 2828568 SGTC_1059 3448-6867 171 µM 1.01077160350831 0.115184394151895 no 399 0.156062878577568 816 3934407 SGTC_577 r071-0003 38.6 µM 1.00862293704797 0.115655604218733 no 400 0.156577751367042 921 4568517 YMR134W ERG29 SGTC_1650 st011916 45.8 µM 1.00837925772507 0.115709130274729 no 401 0.15663621338897 802 242528 SGTC_2275 7947463 200 µM 1.00704114894423 0.116003369858693 no 402 0.156957500155967 761 1225414 SGTC_1382 3002-2117 298 µM 1.00695469325515 0.116022399035719 no 403 0.156978273509348 850 1497314 SGTC_1805 st050013 60.3 µM 1.00458938838424 0.11654387013179 no 404 0.157547304542553 770 4037144 SGTC_2391 6285546 200 µM 1.00340319527981 0.116806011206455 no 405 0.157833181521998 807 846083 SGTC_2886 9058944 51.95 µM 1.00327835741149 0.116833623865706 no 406 0.157863287716623 645 4949929 SGTC_902 1120-0002 2.07 µM 1.00323726403165 0.116842714247231 no 407 0.157873198717933 808 3280475 SGTC_1836 st055642 81 µM 1.00262461715846 0.116978299034329 no 408 0.158021006836692 793 8571 SGTC_2141 5621638 7.665 µM 1.0023394096943 0.117041456275635 no 409 0.15808984740543 802 2856238 SGTC_2205 7238770 200 µM 0.995796132532154 0.118497060581163 no 410 0.15967460489615 799 279867 SGTC_3168 9103419 49.47 µM 0.99499980197212 0.118675080168836 no 411 0.159868180332031 731 16649256 SGTC_1148 3909-7663 27.7 µM 0.993294201338978 0.119057002507506 no 412 0.160283301288907 832 4084526 SGTC_1305 1181-0477 144 µM 0.990308724542264 0.119727605186114 no 413 0.161011621741697 806 6252086 SGTC_2839 9003951 25.97 µM 0.988954278572352 0.120032719779753 no 414 0.161342756024783 790 2990634 SGTC_1118 chelidonine 707.474 nM 0.987232138881545 0.120421455167426 no 415 0.16176442482499 874 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_80 0159-0065 512.242 µM 0.984873418827226 0.120955322312386 no 416 0.162343125757554 729 1548079 SGTC_571 k831-0106 44.2 µM 0.983670494319228 0.121228229724025 no 417 0.162638775893933 773 4783639 SGTC_2122 5258151 111.688 µM 0.983234512929569 0.121327247634796 no 418 0.16274601614036 809 2173356 SGTC_1565 sinapyl alcohol 95.1 µM 0.981497472642115 0.121722320145601 no 419 0.163173740064406 778 5280507 A phenol propionate derived from cinnamic acid. SGTC_2272 7805186 180 µM 0.981240444574435 0.121780855306589 no 420 0.163237091922815 838 2956062 YPR165W RHO1 SGTC_2295 7971645 200 µM 0.980476075317036 0.12195504839151 no 421 0.163425586831413 799 2978226 YKL099C UTP11 SGTC_2523 spermine 47.74 µM 0.97916751942401 0.122253662964197 no 422 0.1637486072456 810 1103 A DNA binding polyamine. SGTC_2816 7982706 58.44 µM 0.978816428875218 0.12233386965548 no 423 0.163835345324279 780 2981853 SGTC_196 k015-0023 18.111 µM 0.978230094243695 0.122467900227464 no 424 0.16398026769861 841 5211998 SGTC_1475 4092-1048 11.7 µM 0.97496550343574 0.123216038973094 no 425 0.164788685918065 860 2881759 SGTC_2493 resveratrol 26.09 µM 0.974695687873672 0.123278014965645 no 426 0.164855616282603 765 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1434 4073-0095 163 µM 0.974065431078764 0.123422868545178 no 427 0.165012026174873 858 24133745 SGTC_1149 3909-7961 23.3 µM 0.972344419205037 0.123819020412445 no 428 0.165439616367323 817 735261 SGTC_2723 salbutamol 83.58 µM 0.971810943955372 0.123941999165792 no 429 0.165572305180199 763 9884233 β2-adrenoceptor agonist SGTC_1946 st076057 65.1 µM 0.971256730838472 0.124069848998077 no 430 0.165710224898964 704 953009 SGTC_2399 5884133 200 µM 0.970861325926912 0.124161120206051 no 431 0.165808669501634 790 722445 SGTC_2123 5259487 200 µM 0.965075225881906 0.125502098913308 no 432 0.16725356729028 877 2173474 SGTC_847 0342-0274 5.54 µM 0.963600142150019 0.125845573186165 no 433 0.1676232177703 878 18097 SGTC_1732 st034308 51.822 µM 0.961370545959259 0.12636597969628 no 434 0.168182944230501 795 830119 SGTC_3180 9109287 49.47 µM 0.960477963866434 0.12657473560049 no 435 0.168407358159204 792 18891271 SGTC_457 grayanotoxin iii 135 µM 0.955305662625884 0.127789155120533 no 436 0.169711572361615 875 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_3242 9133940 49.47 µM 0.954220974444874 0.12804485596385 no 437 0.169985899903047 884 17248444 SGTC_1994 st072947 40.9 µM 0.952211780491214 0.128519435218495 no 438 0.170494793841696 848 5286565 YDL195W SEC31 SGTC_201 4262-0159 12.803 µM 0.948841522651613 0.129318241675726 no 439 0.171350609922462 800 1341029 SGTC_1351 1496-0003 46.5 µM 0.94799720229831 0.129518897317163 no 440 0.171565439233003 894 3891978 SGTC_217 ketoconazole 989 nM 0.947380817782751 0.129665519368361 no 441 0.171722381061516 850 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1620 st003704 16.5 µM 0.947115859808841 0.129728581384838 no 442 0.171789871975638 873 2834414 SGTC_3338 9144300 39.5675 µM 0.939740721440572 0.131492448592873 no 443 0.173675285949739 867 4901274 SGTC_110 0850-0284 111.64 µM 0.939421106803631 0.131569261374714 no 444 0.173757290220613 728 3906265 SGTC_3176 9106582 49.47 µM 0.936623313741571 0.132242975360106 no 445 0.174476177655359 743 17018027 SGTC_2989 9073649 71.4286 µM 0.934980228894769 0.132639739937141 no 446 0.174899244306062 937 21367202 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.934065378940361 0.132861008740656 no 447 0.175135084656386 913 5393153 SGTC_2834 9001755 58.44 µM 0.931017176419713 0.133600091263489 no 448 0.175922339614058 794 2989575 SGTC_576 1073-0113 22.7 µM 0.92913749729275 0.134057254356908 no 449 0.176408916965507 1088 5439563 SGTC_1607 st000305 50.6 µM 0.926306421749409 0.134747836247733 no 450 0.177143379783596 886 5457690 SGTC_1394 3474-0001 65.7 µM 0.925331483494651 0.134986216191207 no 451 0.177396753423074 762 5017666 YIL048W NEO1 SGTC_1029 k015-0030 64.7 µM 0.924961461863166 0.135076765017725 no 452 0.177492977050555 858 2208316 SGTC_3226 9131256 49.47 µM 0.923328324736256 0.1354769112509 no 453 0.177918065651709 802 17178073 SGTC_1456 k015-0012 13 µM 0.92295919553472 0.135567466584349 no 454 0.178014235029368 956 2989616 SGTC_3257 9139206 32.98 µM 0.919581387090069 0.1363980417191 no 455 0.178895778494776 857 4910041 SGTC_2021 4019055 173 µM 0.919429255679958 0.136435531319229 no 456 0.178935546437804 965 44827708 YER133W GLC7 SGTC_1115 galangin 695.678 nM 0.9191936520882 0.136493604799934 no 457 0.178997145422527 974 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2491 paeonol 100 µM 0.917216124976918 0.136981708181939 no 458 0.179514699357558 869 11092 Increases levels of cortical cytochrome oxidase. SGTC_2918 7977171 22.06 µM 0.915100268768008 0.137505274012355 no 459 0.180069496951954 885 2236483 SGTC_3186 9110464 49.47 µM 0.914116642790396 0.137749135542144 no 460 0.180327779173042 871 17018021 SGTC_162 k030-0015 37.8 µM 0.912535134668764 0.138141842985729 no 461 0.180743541404611 961 1809920 YMR134W ERG29 SGTC_2910 7948405 25.97 µM 0.909047565704807 0.139010544040919 no 462 0.181662509255621 867 2971328 SGTC_2991 9074669 71.4286 µM 0.908024479058654 0.139266083538705 no 463 0.18193264431873 923 17333109 SGTC_2997 9067075 71.4286 µM 0.906590855054179 0.139624701685145 no 464 0.182311599762887 916 27209819 SGTC_535 2293-4129 48.2 µM 0.906251368409758 0.139709715457738 no 465 0.182401409774528 969 396118 YIL048W NEO1 SGTC_1355 1499-0035 1.68 µM 0.9039054899278 0.140298128807416 no 466 0.18302275893167 875 1548538 SGTC_3031 9088762 49.47 µM 0.902204401262296 0.140725861708325 no 467 0.183474148630542 962 205253 SGTC_1561 5-methoxyflavone 52.9 µM 0.900855738693518 0.141065606559244 no 468 0.183832513590966 883 94525 SGTC_894 0960-0238 55.9 µM 0.898226323420529 0.141729587209856 no 469 0.184532451163755 942 6741907 YDL195W SEC31 SGTC_3189 9110682 49.47 µM 0.895903526477581 0.142317898762101 no 470 0.18515214528316 896 17122418 SGTC_1371 2421-0008 32.7 µM 0.893024030652292 0.143049500094901 no 471 0.185922151947102 879 2827552 SGTC_978 1416-0512 87.4 µM 0.892734975358611 0.1431230812488 no 472 0.185999557812656 936 6814003 SGTC_2384 9036245 200 µM 0.891299626231927 0.143488838608076 no 473 0.186384224575819 945 6462766 SGTC_193 1273-0060 1.558 µM 0.88770881858974 0.144406614291345 no 474 0.187348700528807 820 2847393 YHR072W ERG7 SGTC_964 1287-0107 19.4 µM 0.885835967107776 0.144886863374653 no 475 0.187852962643801 935 51516812 YPR165W RHO1 SGTC_2490 carminic acid 95.39 µM 0.884575748954498 0.145210621505712 no 476 0.188192745538758 875 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3060 1327-0027 12.5 µM 0.884025003777669 0.145352264220082 no 477 0.1883413577218 907 16000455 YPR107C YTH1 SGTC_211 3455-0679 143.504 µM 0.883814965643964 0.14540630709037 no 478 0.188398053134348 935 748649 SGTC_1567 st069303 68.4 µM 0.882848421828196 0.145655173270077 no 479 0.188659087129837 937 5581319 SGTC_1070 indatraline 8.81 µM 0.8819358840908 0.145890396604595 no 480 0.188905740241663 927 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2768 sulfasalazine 50.2 µM 0.880926319340349 0.146150927713338 no 481 0.189178850513724 953 5384001 An antioxidant and salicylic acid derivative. SGTC_3324 9138759 60.749 µM 0.88068645289364 0.146212874238203 no 482 0.189243775582558 931 45595710 SGTC_6 0844-0013 19.835 µM 0.879989159707564 0.146393053282564 no 483 0.189432591035382 1118 1584900 SGTC_1560 lithocholic acid 53.1 µM 0.879541219712747 0.146508878611777 no 484 0.189553946911476 884 9903 A bile acid which acts as a detergent. SGTC_1188 1403-0014 4.57 µM 0.877915830410712 0.146929677354439 no 485 0.18999469882725 970 9614867 SGTC_2704 st078022 71.1 µM 0.872984188590793 0.148211392133061 no 486 0.191335847988514 954 54697681 SGTC_1875 nocodazole 6 µM 0.87223545611992 0.148406636937774 no 487 0.19153997027303 956 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_485 niflumic acid 177 µM 0.872139668460008 0.148431627614948 no 488 0.191566093889754 919 4488 A COX2 inhibitor. SGTC_2985 9022375 71.43 µM 0.871307952787075 0.14864873773471 no 489 0.191793014654377 944 4939335 SGTC_3312 9133330 71.43 µM 0.869102349463386 0.149225513438185 no 490 0.192395575881336 1005 17617324 SGTC_1001 4048-4355 44.4 µM 0.867478762107366 0.149651042906286 no 491 0.192839871697164 930 21824233 SGTC_2520 obtusaquinone 4.71 µM 0.865493953550123 0.150172344440711 no 492 0.193383866593727 962 5967872 SGTC_2608 thymoquinone 42.66 µM 0.863551903973552 0.150683585735838 no 493 0.193917047435534 912 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_891 0929-0073 133 µM 0.863529637318402 0.150689454107829 no 494 0.193923165834223 965 5603632 SGTC_2304 7443016 91.4 µM 0.862339540865947 0.151003325202799 no 495 0.194250349942431 878 939854 SGTC_3225 9130819 49.47 µM 0.861483817838448 0.151229278737793 no 496 0.194485814957212 967 4547121 SGTC_3106 9121286 49.47 µM 0.858934936006009 0.151903642666523 no 497 0.195188206748249 922 15943471 SGTC_213 1246-0773 967 nM 0.858528662995399 0.152011315623549 no 498 0.195300305106749 965 6251622 SGTC_2239 6685329 187.64 µM 0.856271827613617 0.152610358681293 no 499 0.195923720249535 931 805680 SGTC_1871 st057448 67.3 µM 0.855307726797602 0.152866741556305 no 500 0.196190405534483 982 691747 SGTC_1368 1852-0141 284 µM 0.854778168936217 0.153007688084865 no 501 0.196336983089899 917 2838987 SGTC_1770 st043884 66.3 µM 0.854186214828588 0.153165343873072 no 502 0.196500910001205 999 670149 SGTC_1405 3909-7894 12 µM 0.853833403106807 0.153259359792636 no 503 0.19659865183338 983 7104060 SGTC_2827 7993847 71.43 µM 0.853792384254726 0.15327029282036 no 504 0.196610017476074 885 2985692 SGTC_1227 3909-8010 46.6 µM 0.852250066587575 0.153681752033127 no 505 0.197037656901702 934 15982272 SGTC_1646 st011709 75.6 µM 0.849658331884737 0.154374820025533 no 506 0.197757535486034 940 5757843 SGTC_391 gliotoxin 8.33 µM 0.849275871577144 0.154477270248589 no 507 0.197863901824975 1002 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_967 1306-0166 352 µM 0.848883443225033 0.154582437333692 no 508 0.197973076302191 976 4437607 SGTC_2360 9040895 200 µM 0.848599550233215 0.154658547460561 no 509 0.198052078666463 910 4914414 SGTC_278 4092-0821 23.9 µM 0.847732914149843 0.154891040912686 no 510 0.198293365794168 969 877900 SGTC_653 0203-0016 55.2 µM 0.846845967675671 0.155129221963708 no 511 0.198540491316446 995 295302 SGTC_3133 9127736 49.47 µM 0.843542916246692 0.156018351027347 no 512 0.199462437184354 981 27243420 SGTC_2497 7-hydroxyflavone 100 µM 0.843388003957007 0.156060133250371 no 513 0.199505739389422 917 5281894 SGTC_2430 5571206 200 µM 0.842847440674054 0.156205989222706 no 514 0.199656885868828 1078 1731771 SGTC_2568 diosmetin 100 µM 0.842408538803109 0.156324480731976 no 515 0.199779657547501 988 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_632 0781-2353 4.65 µM 0.841297484864857 0.156624699490542 no 516 0.200090649657721 999 6811515 YHR007C ERG11 SGTC_2669 eugenol 100 µM 0.839835038377826 0.157020446516619 no 517 0.200500442434291 966 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1678 st019265 80.2 µM 0.838185775103634 0.157467535778364 no 518 0.200963187444564 1016 5367020 SGTC_1143 3454-2408 5.08 µM 0.835857163639746 0.158100208767693 no 519 0.201617631666772 957 X1143 SGTC_2246 7293507 91.5585 µM 0.835810366079147 0.158112940528212 no 520 0.20163079695259 1028 887656 SGTC_2170 morpholine 200 µM 0.835094769424736 0.158307709823428 no 521 0.201832175738228 989 121171 Reacts with secondary amines. SGTC_342 k048-0088 23.3 µM 0.834971740866522 0.158341211278574 no 522 0.201866809802249 992 6820570 SGTC_3021 9087658 49.47 µM 0.834127723267888 0.158571168016711 no 523 0.202104507140408 996 25237042 SGTC_553 k007-0256 45.7 µM 0.834043202984444 0.158594208040767 no 524 0.202128319475632 1012 6287000 SGTC_2662 daunorubicin 22.37 µM 0.830671762819149 0.159515044617786 no 525 0.20307954113192 956 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1929 genistein trimethyl ether 50.5 µM 0.828281344990943 0.160170052115285 no 526 0.203755592572678 1040 136420 SGTC_2015 5119600 184 µM 0.827931508074074 0.160266059545707 no 527 0.20385464491616 1003 2828786 SGTC_446 go6976 132 µM 0.827304872123075 0.160438124277097 no 528 0.204032141485122 992 3501 A protein kinase C inhibitor. SGTC_1692 fluoroquinolonic acid 71 µM 0.825758737726189 0.160863185456274 no 529 0.204470482500049 985 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2291 7917025 104.35 µM 0.825060869432382 0.16105528305317 no 530 0.204668516985118 964 2964612 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.824965742893633 0.161081479496255 no 531 0.204695519931387 999 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_502 l-744,832 89.3 µM 0.824143504316069 0.161308027729609 no 532 0.204929011714738 1015 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_568 1193-0097 7.48 µM 0.823666657318701 0.161439506714216 no 533 0.205064494874697 977 3646150 SGTC_3039 9090270 49.47 µM 0.822524502421065 0.161754712272108 no 534 0.205389223651384 1014 17173750 SGTC_1748 st037455 53.6035 µM 0.821746377887673 0.161969684292957 no 535 0.205610628893614 987 580690 SGTC_1634 st006576 41 µM 0.820539116847984 0.162303581804073 no 536 0.205954419651532 1002 3915356 SGTC_1400 3771-8998 51.5 µM 0.820173133019623 0.162404892011475 no 537 0.206058707883477 975 670767 SGTC_101 0490-5701 117.494 µM 0.817405763391151 0.163172276316001 no 538 0.206848291577366 953 4661669 SGTC_2718 lomofungin 53.02 µM 0.816250253099511 0.163493392500621 no 539 0.207178510153487 998 5351222 A RNA synthesis inhibitor. SGTC_2221 6807166 181.081 µM 0.814068418633399 0.164100842356374 no 540 0.207802878397509 983 674925 SGTC_507 nimesulide 162 µM 0.813495648552528 0.164260550967573 no 541 0.207966970069013 1018 4495 A COX2 inhibitor. SGTC_2622 2-methoxyxanthone 59.94 µM 0.809501642759375 0.165377022169192 no 542 0.209113329145332 1041 71034 A hepatoprotective. SGTC_2861 9024595 19.48 µM 0.808556442779041 0.165641957039515 no 543 0.209385163796796 977 16482810 SGTC_3231 9132313 49.47 µM 0.80502341617064 0.166634675645406 no 544 0.210403083654536 1024 4905967 SGTC_1156 4092-0367 4.88 µM 0.804912467039935 0.166665912464258 no 545 0.210435096799143 1026 1357585 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.804255228854278 0.166851029978471 no 546 0.210624794235811 1118 65057 A dermal irritant. YDR527W RBA50 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.802347261763337 0.167389178537756 no 547 0.211176055340744 1099 368090 SGTC_1009 4106-0057 9.87 µM 0.800672842482733 0.167862374593764 no 548 0.211660534264417 1082 2928005 SGTC_940 3232-1287 54.8 µM 0.800386208253946 0.167943464556098 no 549 0.21174353459941 1042 1585493 YIL048W NEO1 SGTC_2757 clomiphene 4.22 µM 0.79880825561729 0.168390325012743 no 550 0.212200801408966 1120 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_450 aminopyrene 156 nM 0.79740437974023 0.168788530821507 no 551 0.21260810823097 1028 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_722 3534-0461 190 µM 0.792321625883134 0.170235297314163 no 552 0.214086582543871 1073 658262 SGTC_435 c-PAF 6.7 µM 0.790976363173406 0.170619541746147 no 553 0.214478892397136 1047 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1280 0880-0253 10.1 µM 0.790352454761286 0.170797935655859 no 554 0.214660980370252 1034 6836607 SGTC_143 4032-1194 15.74 µM 0.790019343530154 0.170893230892857 no 555 0.21475823582288 1081 1806963 SGTC_1571 st070080 73.4 µM 0.789390075713968 0.171073342331243 no 556 0.214942027264147 1053 4315245 SGTC_600 1495-0418 41.6 µM 0.78875092379295 0.171256407078619 no 557 0.215128799056111 1044 5377768 SGTC_417 st075190 100 µM 0.786911426749421 0.17178397118298 no 558 0.215666858960429 1074 222757 SGTC_2375 9072683 200 µM 0.786620100970478 0.171867617949369 no 559 0.215752144373978 1141 16798029 SGTC_2687 chenodiol 100 µM 0.785827655426448 0.172095280044395 no 560 0.215984231130598 1019 5702181 A cholesterol synthesis inhibitor. SGTC_2928 9011484 9.79 µM 0.783367596594683 0.172803257237683 no 561 0.216705639374814 1022 2994751 SGTC_1759 st043059 70 µM 0.782140204843871 0.173157179870731 no 562 0.217066090465595 1086 669426 SGTC_2642 cholecalciferol 100 µM 0.781965901402757 0.173207478277607 no 563 0.217117306654527 1065 9821465 A vitamin D precursor, similar to steriods. SGTC_3262 9137218 49.47 µM 0.780664848871534 0.173583214368712 no 564 0.21749981995949 942 17650664 SGTC_2317 5986382 200 µM 0.780377008380254 0.173666410973721 no 565 0.217584498438325 1091 877883 SGTC_974 1326-0144 138 µM 0.780279463111451 0.173694610938038 no 566 0.217613199151006 1082 5411856 SGTC_807 1315-0151 48 µM 0.779986385936594 0.173779355952897 no 567 0.217699444294343 1120 4011080 SGTC_695 3505-6186 243 µM 0.779796667578693 0.173834228168954 no 568 0.217755284085311 1075 1819379 SGTC_3197 9113331 49.47 µM 0.776578138274321 0.174766801761 no 569 0.218703851892747 1073 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_470 aa-861 153 µM 0.776329502238527 0.174838976323948 no 570 0.218777228950477 1095 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1765 st044815 90.4 µM 0.775336899135109 0.175127299605543 no 571 0.219070305478443 1065 645695 SGTC_1346 1488-2224 62.4 µM 0.773299134955684 0.175720157293285 no 572 0.219672683804836 1085 3722427 SGTC_634 1611-4317 11.2 µM 0.77314582883677 0.175764810835756 no 573 0.219718040675261 1123 2843522 SGTC_778 3456-2434 196 µM 0.771411561839324 0.176270452080283 no 574 0.220231512083589 1149 5539063 SGTC_2149 5554786 194.827 µM 0.771002312439663 0.176389906556567 no 575 0.220352780468123 1124 745063 YPR165W RHO1 SGTC_3284 9108171 64.8615 µM 0.770998670282406 0.176390969883875 no 576 0.220353859880445 1007 8687505 SGTC_1501 4491-0275 38.4 µM 0.770173824175462 0.176631888043785 no 577 0.220598394454224 1090 5104718 SGTC_2443 5493264 126.67 µM 0.768496000030175 0.177122582766518 no 578 0.221096283073921 1083 5340055 SGTC_3177 9107506 49.47 µM 0.767084404727192 0.17753608280799 no 579 0.221515666793618 1063 8897194 SGTC_230 MPP+ 141.667 µM 0.766304385965831 0.17776483563475 no 580 0.221747604604883 1060 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_3090 9117696 49.47 µM 0.766170897113121 0.177804001975378 no 581 0.221787311282635 1077 7923821 SGTC_619 1652-1634 108 µM 0.766166506194144 0.177805290386866 no 582 0.221788617444243 1018 5400454 SGTC_67 0335-0847 266 µM 0.765305565679418 0.178058026827574 no 583 0.222044805310807 1149 4552207 YOR254C SEC63 SGTC_3027 9089541 49.47 µM 0.764816720695856 0.178201632209545 no 584 0.222190344824053 1089 9943819 SGTC_1491 4138-0063 26.5 µM 0.76365962297127 0.178541837423566 no 585 0.222535054188241 1074 23883227 SGTC_2969 9091408 28.7 µM 0.763506322233295 0.17858694095799 no 586 0.222580746661625 1013 4286311 SGTC_2009 4012297 12.05 µM 0.761287119104197 0.179240669721188 no 587 0.223242796250366 1041 45595307 SGTC_816 0325-0417 81.3 µM 0.759685547903594 0.179713391381519 no 588 0.223721284721464 1100 68101 SGTC_674 0498-0004 451 µM 0.75943502101476 0.17978740798195 no 589 0.223796185314504 1063 4231473 SGTC_2699 st077704 54.6 µM 0.759098490561592 0.179886863931906 no 590 0.223896821018613 1075 645852 SGTC_1162 k048-0130 20.1 µM 0.758837813404311 0.179963926453152 no 591 0.223974791306853 1058 6797406 SGTC_2094 5332512 191.667 µM 0.755724727153289 0.18088583217416 no 592 0.224907127722159 1142 755774 SGTC_1717 st033143 58.0435 µM 0.753837192264855 0.181446243338535 no 593 0.225473494122528 1116 674616 SGTC_2651 TUB2.036 5 µM 0.753814317374082 0.181453041577577 no 594 0.225480362821216 1222 15992207 YFL037W TUB2 SGTC_1938 st074717 56.4 µM 0.753738572027602 0.181475553641619 no 595 0.225503107904719 1029 17250979 SGTC_803 4488-1585 147 µM 0.753193022628095 0.181637746502373 no 596 0.225666965784751 1081 747204 SGTC_1386 3228-0095 33.8 µM 0.752714278831003 0.181780152635338 no 597 0.225810813822152 1086 870181 SGTC_2702 st077768 96.8 µM 0.751455723458748 0.182154852928755 no 598 0.226189218926309 1041 6484119 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.748974378224564 0.182895018354862 no 599 0.226936324248398 1142 4213774 SGTC_3334 9142812 21.919 µM 0.748727799342085 0.182968673254253 no 600 0.227010642341887 1079 45283678 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.747308570353586 0.183392967005012 no 601 0.227438660176635 1121 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_658 3253-0951 102 µM 0.747199607422601 0.183425567979751 no 602 0.227471540515347 1142 1184878 SGTC_2395 5646831 180.19 µM 0.742467109190349 0.184844984040891 no 603 0.228902186265765 1102 6808628 SGTC_2684 capsaicin 100 µM 0.742023837916674 0.184978282958965 no 604 0.229036446401591 1120 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_172 1112-0046 2.638 µM 0.741576157960757 0.185112968245346 no 605 0.229172086689191 1028 2802135 YIL048W NEO1 SGTC_1367 1812-0510 76.9 µM 0.741357097537652 0.185178895141938 no 606 0.229238475111749 1109 1142582 YDR527W RBA50 SGTC_2208 7283366 200 µM 0.739853100434102 0.185631921275229 no 607 0.229694567341184 1141 898663 SGTC_1006 4099-6547 255 µM 0.738260098224653 0.186112506280148 no 608 0.230178204419467 1118 3146833 SGTC_808 0711-0032 135 µM 0.737396276321932 0.186373430647164 no 609 0.230440699634156 1126 4252555 SGTC_650 1328-0195 38 µM 0.736167937805368 0.186744850209556 no 610 0.230814250894016 1128 2780821 SGTC_1821 st053465 65.6 µM 0.73585742842841 0.186838813161807 no 611 0.230908733734002 1106 675086 SGTC_3289 9119912 71.43 µM 0.735152436470213 0.187052258725711 no 612 0.231123331216801 1154 17014829 SGTC_1922 5578187 25 µM 0.734346035699376 0.187296592000838 no 613 0.231368933646118 1114 1350412 SGTC_1210 3013-0140 750 nM 0.734080337315929 0.187377139781179 no 614 0.231449888264635 1164 905973 SGTC_3175 9106517 49.47 µM 0.733025461685336 0.187697141770382 no 615 0.231771450039331 1119 41468073 SGTC_443 clozapine 122 µM 0.732530046125673 0.187847545082224 no 616 0.231922555312709 1050 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_413 propylparaben 100 µM 0.730176562252447 0.188563055825815 no 617 0.232641133514714 1135 7175 A pharmaceutical preservative. SGTC_2831 7999036 19.48 µM 0.729679157036444 0.18871449275932 no 618 0.232793162187482 1140 2988270 SGTC_1271 0832-2808 169 µM 0.729410876558692 0.188796202895529 no 619 0.232875183284235 1164 3663794 SGTC_1939 st074455 53.6 µM 0.727820089354592 0.189281156474162 no 620 0.233361862604354 1146 1644229 SGTC_1256 0570-0116 285 µM 0.727576705717184 0.189355419879184 no 621 0.233436372201656 1146 410638 SGTC_781 4335-2806 94.4 µM 0.725817663696615 0.189892687673257 no 622 0.233975278461141 1220 845254 SGTC_2216 7189485 200 µM 0.725560866747627 0.189971200014433 no 623 0.234054009281852 1152 731273 SGTC_2220 6782180 200 µM 0.724671012858351 0.190243415656883 no 624 0.234326941142127 1091 833803 SGTC_1540 guanosine 70.6 µM 0.724300249434964 0.190356906766873 no 625 0.234440711946376 1096 6802 Guanosine is a purine nucleoside SGTC_1151 3909-8316 15.3 µM 0.723808037641406 0.190507637593074 no 626 0.234591797062233 1161 800431 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.721362460661252 0.191257636698481 no 627 0.235343268336802 1000 4000243 SGTC_2645 abamectin 100 µM 0.72092669324038 0.191391465726268 no 628 0.235477309290144 1150 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1043 0916-0009 19.3 µM 0.71990795315292 0.191704555975922 no 629 0.235790835456118 1212 3101130 SGTC_3270 9137563 49.47 µM 0.719750888056766 0.191752854815667 no 630 0.235839194082122 1101 17015724 SGTC_1359 1582-0056 520 nM 0.718936082582077 0.192003533932275 no 631 0.236090151514317 1172 3661189 SGTC_1241 0364-0022 50.8 µM 0.717656370818515 0.192397648503265 no 632 0.236484595383199 1145 4563895 SGTC_392 N-ethylmaleimide 8.33 µM 0.717370846065177 0.192485649399043 no 633 0.236572651764246 1127 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_3124 9127567 49.47 µM 0.715135741263978 0.193175375597084 no 634 0.237262585371748 1124 17592030 SGTC_48 0382-0018 55 µM 0.714621586370728 0.193334250733896 no 635 0.237421451244436 1272 762596 SGTC_282 k297-0036 65.7 µM 0.714191743775073 0.19346713433606 no 636 0.237554310734825 1152 5061378 SGTC_2558 carylophyllene oxide 100 µM 0.712932790532871 0.193856653639338 no 637 0.237943673619534 1257 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2288 7946289 167.31 µM 0.711721864541725 0.194231763992923 no 638 0.238318512751973 1202 1246052 SGTC_2752 diclazuril 33.15 µM 0.710461691984215 0.194622598543617 no 639 0.23870893920714 1243 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1738 st035555 74 µM 0.710095129619012 0.194736375326182 no 640 0.238822573169349 1189 5331140 SGTC_3148 9097893 49.47 µM 0.709522589164483 0.194914166296967 no 641 0.239000119314436 1128 17174100 SGTC_1073 triclabendazole 3.09 µM 0.709517268704538 0.194915818921989 no 642 0.239001769539956 1221 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2372 9071633 200 µM 0.707409746792221 0.195571120951323 no 643 0.239655940805331 1214 21321366 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.707216372314061 0.195631314747652 no 644 0.239716012826441 1211 1273210 SGTC_797 k781-0471 270 µM 0.706596304633415 0.195824405868687 no 645 0.239908693024081 1177 23738129 SGTC_1906 st060206 94.7 µM 0.705889981119877 0.196044498197248 no 646 0.240128279283111 1188 5133468 SGTC_1171 0368-0077 21.4 µM 0.704987782523909 0.196325843865663 no 647 0.240408919676379 1159 3239779 SGTC_2074 5212007 75.395 µM 0.704983120231307 0.196327298411359 no 648 0.240410370405867 1115 758611 SGTC_1747 st037496 66.6 µM 0.704078583052612 0.196609620194372 no 649 0.240691918419707 1214 723305 SGTC_1307 1187-1599 12.2 µM 0.703378728225548 0.196828225730212 no 650 0.240909879686063 1179 1538471 SGTC_1638 st008370 60.6 µM 0.702704549916672 0.19703895010796 no 651 0.241119945800798 1200 24207134 SGTC_1602 st001878 87.6 µM 0.702618281142235 0.197065924536779 no 652 0.241146833331623 1187 595405 YLR310C CDC25 SGTC_1096 rimcazole 32.2 µM 0.701836185693996 0.197310571268186 no 653 0.241390664657748 1127 18528119 A dopamine reuptake inhibitor. SGTC_2678 equilin 100 µM 0.70062913683165 0.197688507740362 no 654 0.241767245037345 1210 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2766 oltipraz 83.91 µM 0.699172353287426 0.198145220290685 no 655 0.242222163012234 1163 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2591 skatole 100 µM 0.699088010375686 0.198171681919173 no 656 0.242248515448606 1200 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2921 7974240 10.71 µM 0.69840126829588 0.198387218824202 no 657 0.242463141713623 1184 2979074 YDR527W RBA50 SGTC_2004 4023728 41.89 µM 0.697229646893478 0.19875526352269 no 658 0.242829544088152 1173 360084 YDR527W RBA50 SGTC_1126 isoteolin 1.0172 µM 0.69707139096407 0.198805008438395 no 659 0.242879058588954 1185 133323 SGTC_1872 amphotericin b 148 nM 0.696633028839959 0.198942838901676 no 660 0.243016240148089 1207 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_3299 9121982 43.1275 µM 0.695079293737134 0.199431830185443 no 661 0.243502805182687 1217 17594604 YPL160W CDC60 SGTC_644 1498-1197 63.3 µM 0.694266490737412 0.199687923436633 no 662 0.24375755068238 1224 6741615 SGTC_936 3005-4620 401 µM 0.693707438777 0.199864181073861 no 663 0.243932850004981 1210 777207 SGTC_3059 1327-0034 3 µM 0.692978597096837 0.20009411038973 no 664 0.244161491606677 1170 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1708 st033234 31.827 µM 0.69253322837157 0.200234690092156 no 665 0.244301263061112 1250 674664 SGTC_1700 st030840 7.9285 µM 0.692044241374632 0.200389106145692 no 666 0.244454773030702 1211 5499307 SGTC_2789 5281112 71.43 µM 0.69063648868122 0.200834056299083 no 667 0.244897005437416 1210 765948 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.690547318324507 0.200862260438173 no 668 0.244925031966771 1142 1241132 A phosphatase inhibitor. SGTC_224 benfluorex 43.875 µM 0.689344956685813 0.201242793472827 no 669 0.245303106567618 1213 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2415 st077333 57.7 µM 0.689112523833874 0.201316405505235 no 670 0.245376229696103 1246 2766255 SGTC_1347 1493-0251 600 nM 0.687352936639454 0.20187419435345 no 671 0.245930173788446 1230 3986378 SGTC_1117 retinoic acid 1.10837 µM 0.687153155633504 0.201937583337575 no 672 0.245993110200714 1222 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.685407437648393 0.202491993066728 no 673 0.246543425992115 1197 803109 SGTC_1581 himbacine 57.9 µM 0.684629570763428 0.20273932288579 no 674 0.246788851062504 1213 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2182 6325192 200 µM 0.684391945957471 0.202814913823317 no 675 0.246863850226039 1158 736248 SGTC_2114 5491910 81.25 µM 0.683885930447843 0.202975938746255 no 676 0.247023599530287 1252 2849228 SGTC_2057 5236571 38.335 µM 0.683157780971988 0.203207785367605 no 677 0.247253573641469 1215 54684039 YBR257W POP4 SGTC_468 gf-109203x 121 µM 0.679059801078075 0.20451554909008 no 678 0.248549985892863 1142 2396 A protein kinase C inhibitor. SGTC_655 k060-0012 42 µM 0.678802736153938 0.204597751283034 no 679 0.248631429944999 1185 5994525 SGTC_1295 1013-0063 9.78 µM 0.678205489228618 0.204788810070346 no 680 0.2488207063073 1225 6826038 SGTC_270 tamoxifen 5.46 µM 0.676400221661674 0.205366958384598 no 681 0.249393288280962 1311 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2259 7964009 200 µM 0.675631917971944 0.205613306278993 no 682 0.249637185688128 1237 313134 SGTC_2934 9036370 36.88 µM 0.675191661153515 0.205754548675717 no 683 0.249777001951274 1223 6462800 SGTC_2238 6671620 73.2395 µM 0.673028470732152 0.206449375522234 no 684 0.250464589130579 1206 729941 SGTC_1866 st057638 64 µM 0.672532535715186 0.206608867832695 no 685 0.250622367222197 1227 688802 SGTC_564 3555-0129 330 µM 0.671665420489762 0.206887906680915 no 686 0.250898360028341 1151 563260 SGTC_496 calpeptin 138 µM 0.671273529881772 0.207014090755819 no 687 0.251023147064652 1197 73364 A calpain inhibitor. SGTC_3142 9086498 49.47 µM 0.670607121815501 0.207228770688394 no 688 0.251235422189329 1180 25236367 SGTC_1604 st002052 72.4 µM 0.670344462125345 0.207313421318328 no 689 0.251319114893889 1266 6254834 YHR062C RPP1 SGTC_50 0929-0078 56.389 µM 0.669944785923627 0.207442269195662 no 690 0.251446494197531 1151 1377751 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.669471769674553 0.207594821632485 no 691 0.251597291507061 1212 689007 SGTC_3209 9113616 49.47 µM 0.66917293626342 0.207691232534715 no 692 0.251692584046575 1258 16649353 SGTC_1168 k815-0004 80.5 µM 0.664733539093959 0.209126602420211 no 693 0.253110469004289 1227 642433 SGTC_1369 1866-0067 208 µM 0.664312744283006 0.209262958467324 no 694 0.253245082986255 1266 3531355 SGTC_3135 9127742 49.47 µM 0.663123132944313 0.209648727912465 no 695 0.253625848070966 1238 3643468 SGTC_815 1582-0027 36.9 µM 0.662305146735425 0.20991422853281 no 696 0.253887839532194 1274 3128206 SGTC_2994 9053520 71.4286 µM 0.661799618788482 0.210078410718499 no 697 0.254049825239483 1240 4647384 SGTC_2158 5657123 3.6195 µM 0.660390172194684 0.210536560116117 no 698 0.254501738657958 1225 2858827 SGTC_1086 cerivastatin 2.18 µM 0.659731547179455 0.210750851149725 no 699 0.254713059094695 1224 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2958 9077254 16.72 µM 0.658711016289099 0.211083144900642 no 700 0.255040678748909 1269 16457351 SGTC_173 1273-0061 2.693 µM 0.656835936310689 0.21169448709748 no 701 0.255643207270671 1206 2847414 YPL266W DIM1 SGTC_2639 lactacystin 53 µM 0.656075674919722 0.211942654081961 no 702 0.255887717378863 1272 3870 A proteasome inhibitor. SGTC_2222 6885208 172.143 µM 0.653587572905712 0.212756017229609 no 703 0.256688776334622 1230 609514 SGTC_586 0957-0265 8.15 µM 0.652292566695383 0.21318007617771 no 704 0.257106227191412 1173 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2218 6965428 192.983 µM 0.652072597396877 0.213252155627454 no 705 0.257177170308619 1242 675684 SGTC_1754 st042065 16.137 µM 0.649086216302902 0.21423213705885 no 706 0.2581413253057 1221 1126236 YIL048W NEO1 SGTC_1332 1480-0653 17.5 µM 0.648828687474031 0.214316767715078 no 707 0.258224556336832 1228 5749438 SGTC_1802 st050112 57.9 µM 0.648534343468805 0.214413520604279 no 708 0.258319702738882 1262 4662563 SGTC_1976 st070609 63.5 µM 0.647947278793806 0.214606568613183 no 709 0.258509525039854 1222 682556 SGTC_1972 st070201 17.4 µM 0.647844293401879 0.21464044433202 no 710 0.25854283192524 1263 2829099 SGTC_657 3534-0529 86.7 µM 0.647272192532105 0.214828686125843 no 711 0.258727897633435 1318 1049549 SGTC_1697 st025554 27.742 µM 0.646393257305906 0.215118074255151 no 712 0.259012353002338 1243 1269519 SGTC_2641 levomentholum 100 µM 0.644576270558681 0.215717031432851 no 713 0.259600908291107 1229 16666 SGTC_2346 9031566 143.75 µM 0.64304731486047 0.216221789362281 no 714 0.260096699470458 1265 4771086 SGTC_1503 4585-0012 61.3 µM 0.642651870701462 0.216352449543538 no 715 0.260225008705599 1304 2922052 SGTC_798 1287-0182 476 µM 0.64082613963919 0.216956288446773 no 716 0.260817823883618 1310 1649755 SGTC_2784 7567673 72.73 µM 0.639953237718586 0.217245334260119 no 717 0.26110150057339 1297 3471247 SGTC_326 k292-0812 17.5 µM 0.639520735503487 0.217388631975615 no 718 0.261242114384471 1262 3579357 SGTC_1834 st055981 52.8 µM 0.63895448804038 0.217576324975695 no 719 0.261426269844687 1346 471719 YDL150W RPC53 SGTC_3336 9143619 71.43 µM 0.638886329710386 0.21759892359595 no 720 0.261448440846341 1302 45595730 SGTC_2916 7875993 68.79 µM 0.638342018994069 0.217779444207791 no 721 0.261625532546984 1295 1299250 SGTC_587 k089-0003 57 µM 0.635089644407842 0.21885989272571 no 722 0.262684975284996 1244 9659696 SGTC_223 busulfan 5 mM 0.634967721026158 0.218900455918757 no 723 0.262724733782064 1299 2478 A DNA alkylator. SGTC_296 1222-0039 74.9 µM 0.634036267409857 0.219210487764465 no 724 0.263028576881846 1250 5984176 SGTC_1322 1348-1070 12 µM 0.632411485630823 0.219751895765852 no 725 0.263559015347349 1272 6758089 SGTC_2848 9016370 25.97 µM 0.631522432474239 0.220048469736869 no 726 0.263849493206127 1315 7894410 SGTC_1044 1222-0021 1.78 µM 0.630850115103363 0.220272896495371 no 727 0.26406926592284 1294 4306703 SGTC_565 1418-0001 44.5 µM 0.628717718699362 0.220985580926274 no 728 0.264766937979903 1335 2862145 SGTC_2781 5567276 71.43 µM 0.628382924619488 0.221097594754507 no 729 0.264876560120453 1311 2853274 SGTC_1482 3346-2049 8.48 µM 0.628371566862703 0.221101395349036 no 730 0.26488027941277 1307 3826804 SGTC_1811 st050069 61.5 µM 0.626835669960795 0.221615689774129 no 731 0.265383479584469 1288 3877702 SGTC_871 0574-0004 149 µM 0.626096207044743 0.221863542222475 no 732 0.265625919958648 1307 9551173 SGTC_1793 st048256 72.231 µM 0.625933771726847 0.221918008331962 no 733 0.265679191058181 1238 672022 SGTC_875 0709-0210 25.7 µM 0.625227395201052 0.222154951892458 no 734 0.265910912122402 1334 6251364 SGTC_2620 irigenin 100 µM 0.624520249292179 0.22239229808737 no 735 0.266142988105014 1362 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2866 9034245 58.44 µM 0.624355135886125 0.222447737512307 no 736 0.266197190917467 1295 6462273 SGTC_2790 5423970 71.43 µM 0.622169000543186 0.22318250952047 no 737 0.266915373710118 1358 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_425 3825-7017 13.1 µM 0.622134302600881 0.223194182816114 no 738 0.266926780462721 1385 3397440 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.621923050056244 0.223265261198908 no 739 0.266996233856905 1181 6708630 An antioxidant. SGTC_1248 0469-0687 58.6 µM 0.621098639075344 0.223542767100071 no 740 0.267267362323019 1336 4017482 SGTC_1464 k208-0027 110 µM 0.620924216038488 0.22360150496797 no 741 0.267324743565521 1383 X1464 SGTC_1674 st016616 23.6 µM 0.620764055954016 0.223655447441318 no 742 0.267377438092014 1279 625830 SGTC_2533 agelasine 13.65 µM 0.619831762995339 0.223969593813901 no 743 0.267684277280672 1362 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2282 7944268 200 µM 0.619499346745017 0.224081665731429 no 744 0.267793726064655 1361 2970414 SGTC_109 0132-0036 33.701 µM 0.618052476286224 0.22456983933572 no 745 0.268270373837908 1203 67274 A color developer. SGTC_1679 SEC14.276 6.7 µM 0.617863807838962 0.22463354044447 no 746 0.268332559008754 1344 1005053 YMR079W SEC14 SGTC_132 0417-1715 25.805 µM 0.615498449203881 0.2254330380411 no 747 0.269112796576514 1352 6769098 SGTC_1237 0330-0133 46.1 µM 0.614489384481283 0.225774594209971 no 748 0.269445992889621 1284 X1237 YHR072W ERG7 SGTC_2089 5281248 129.67 µM 0.614389743081041 0.225808337487256 no 749 0.269478906004967 1330 2737878 SGTC_1955 wogonin 32.4 µM 0.614094994861456 0.225908169831185 no 750 0.269576277754196 1395 5281703 A flavanone. SGTC_3081 9117243 49.47 µM 0.613875745541865 0.225982446594209 no 751 0.269648719445184 1404 45595589 SGTC_245 methotrexate 289.6 µM 0.611859069925843 0.226666298363067 no 752 0.270315501895521 1343 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_112 phenothiazine 287.218 µM 0.610905358981032 0.226990106681851 no 753 0.270631118427301 1327 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_65 0798-0905 34.986 µM 0.610313494913784 0.227191190191301 no 754 0.27082707959466 1514 3602145 SGTC_406 estrone 100 µM 0.609560514472481 0.227447157417829 no 755 0.271076487350364 1398 5870 A steroid. SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.608680928539352 0.227746368354127 no 756 0.271367975305905 1385 6710655 SGTC_40 0327-0103 19.753 µM 0.60819370205332 0.227912204703146 no 757 0.271529505575985 1296 409036 SGTC_383 2324-0395 7.37 µM 0.607525931382846 0.228139602856971 no 758 0.27175096945098 1362 3146421 SGTC_1130 3454-2858 15.9 µM 0.606861004736252 0.22836615923141 no 759 0.271971579405386 1328 715628 YIL048W NEO1 SGTC_2453 5731132 22.18 µM 0.606696612545594 0.228422191060442 no 760 0.27202613532285 1404 1362040 SGTC_1492 4158-0558 28.5 µM 0.605903561714861 0.228692604902388 no 761 0.272289397095719 1379 3967268 SGTC_1605 st000082 49.1 µM 0.605820654121527 0.228720885042022 no 762 0.272316926472303 1385 1114022 SGTC_1142 3253-1408 9.78 µM 0.605728831647507 0.228752208377541 no 763 0.272347417639139 1327 256655 SGTC_152 4469-0003 551.229 µM 0.60532703994157 0.228889299619324 no 764 0.272480859146127 1327 697280 SGTC_1758 st042942 75.2445 µM 0.604946126486908 0.229019309773048 no 765 0.272607396622094 1299 669317 SGTC_2199 6590217 200 µM 0.604941150036658 0.22902100856702 no 766 0.272609049966087 1314 703109 SGTC_5 0352-0601 109.883 µM 0.60427597245133 0.22924814160443 no 767 0.272830089097165 1250 762456 SGTC_1296 1068-0102 11.9 µM 0.601904381723358 0.230058977420734 no 768 0.273618893700427 1327 767053 SGTC_382 3229-0966 23.2 µM 0.600281712507723 0.230614683805375 no 769 0.274159252145957 1394 5722370 SGTC_2301 7769476 200 µM 0.600256472729935 0.230623333449742 no 770 0.274167661302768 1383 977820 SGTC_1398 3558-0053 112 µM 0.599691213232443 0.230817094746862 no 771 0.274356022628841 1290 4532369 SGTC_3328 9140624 29.0385 µM 0.599456105803652 0.230897712319529 no 772 0.274434386244386 1364 4904392 SGTC_309 k408-0051 1.48 µM 0.599237116439924 0.230972817200236 no 773 0.274507387485793 1325 3640463 SGTC_2276 7947513 42.08 µM 0.598252652969795 0.231310618497532 no 774 0.274835681803066 1200 2105100 SGTC_1041 0206-0046 107 µM 0.597351099452346 0.231620212283256 no 775 0.275136497359979 1369 50494 SGTC_2860 9025725 38.96 µM 0.5962313870388 0.232005043231762 no 776 0.275510330181744 1293 40546248 SGTC_1886 st057356 49.9 µM 0.596201099522294 0.232015457609549 no 777 0.275520445593665 1275 24207747 SGTC_775 4577-0580 57.3 µM 0.596143657765208 0.232035209701526 no 778 0.275539630469053 1406 2006902 SGTC_3310 9130229 44.1445 µM 0.595616367741965 0.232216568937804 no 779 0.275715769862612 1391 7761258 SGTC_2167 5876490 200 µM 0.594274647160674 0.23267840375603 no 780 0.27616421637931 1515 686534 SGTC_151 3013-0144 2.285 µM 0.594268833090819 0.23268040613241 no 781 0.276166160408718 1403 906558 YHR107C CDC12 SGTC_1808 st050063 61.5 µM 0.593361829316526 0.232992897172146 no 782 0.276469514193891 1391 4011993 SGTC_1830 st055982 50.3 µM 0.592153341549643 0.233409620755675 no 783 0.276873955137486 1327 455313 An antimicrobial agent. SGTC_1208 2323-2347 50.3 µM 0.591505695184319 0.233633119118221 no 784 0.277090820168014 1353 5412760 SGTC_2003 4023581 200 µM 0.590741194061862 0.233897095898147 no 785 0.277346921061279 1378 16641307 SGTC_1334 1486-0610 236 µM 0.590269508899789 0.234060047817895 no 786 0.277504988996316 1365 3742339 SGTC_35 0133-0054 64.071 µM 0.590248998194921 0.234067135027156 no 787 0.277511863403501 1283 99677 SGTC_2919 7978188 46.38 µM 0.589142215076063 0.234449745838078 no 788 0.277882938320506 1350 2980291 SGTC_1505 k297-0037 20.6 µM 0.587452406262091 0.235034573356835 no 789 0.278449953003778 1330 4089396 SGTC_1630 st005209 31.3 µM 0.586932539190958 0.235214656616454 no 790 0.278624507519849 1370 3367314 SGTC_1455 4262-0120 131 µM 0.586869899447523 0.235236360323035 no 791 0.278645543512405 1428 1529587 SGTC_1061 3448-9325 110 µM 0.586829503730712 0.235250357403365 no 792 0.27865910981463 1323 723482 SGTC_226 1,3-diallylurea 8.28947 mM 0.584707691010153 0.235986209718681 no 793 0.27937214087181 1326 74537 YKL182W FAS1 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.584332871908296 0.23611633003464 no 794 0.279498190158888 1378 5379071 SGTC_3096 9117468 49.47 µM 0.584213370500719 0.236157823850824 no 795 0.279538383529687 1275 41316311 SGTC_2164 5685496 200 µM 0.584033551916669 0.236220268836833 no 796 0.27959886940266 1356 759046 SGTC_57 miconazole 162.5 nM 0.583808047887135 0.236298591702653 no 797 0.279674731542471 1294 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2425 5628681 7.85 µM 0.583666706086047 0.236347690331544 no 798 0.279722285636357 1374 5714958 SGTC_3207 9114163 49.47 µM 0.583098060282702 0.236545280494104 no 799 0.27991364472457 1502 849233 SGTC_1170 0310-0127 64.8 µM 0.58293804631953 0.236600897718824 no 800 0.279967503616935 1388 774975 SGTC_2076 5212012 200 µM 0.580907864695352 0.237307167174161 no 801 0.280651275753343 1302 604802 SGTC_458 nppb 133 µM 0.579647710861193 0.237746137319649 no 802 0.281076105864482 1456 4549 A chloride channel blocker. SGTC_515 4092-1064 102 µM 0.578725181228863 0.238067779451885 no 803 0.281387311054859 1467 717353 SGTC_178 4092-0806 87.505 µM 0.578607360076806 0.238108875242099 no 804 0.281427068692087 1368 2169044 SGTC_3089 9117425 49.47 µM 0.578451983415323 0.238163076264862 no 805 0.281479503226017 1291 9401657 SGTC_1804 st050076 49.1 µM 0.578330850935313 0.238205336362587 no 806 0.281520384739731 1391 3895976 SGTC_3221 9128209 49.47 µM 0.577523556754784 0.238487086047329 no 807 0.281792915001432 1392 16460723 SGTC_2186 6124449 200 µM 0.576232668216631 0.238937991435424 no 808 0.28222896342118 1375 3834182 YLR033W RSC58 SGTC_1656 st012921 11 µM 0.575704494091311 0.239122616149489 no 809 0.282407468591813 1383 6732821 SGTC_2348 9022543 33.42 µM 0.573245163265171 0.239983307854789 no 810 0.283239354418269 1405 3162678 YDL140C RPO21 SGTC_2056 5235370 200 µM 0.570886332867826 0.240810412069701 no 811 0.284038347975027 1360 5511916 SGTC_812 4251-0442 148 µM 0.56938086067435 0.241339103109619 no 812 0.284548851285201 1372 5723007 SGTC_570 0987-0065 62.6 µM 0.566370988681193 0.242397996779183 no 813 0.285570806049439 1305 3104428 SGTC_2180 6301957 200 µM 0.565389592327315 0.242743802155413 no 814 0.285904401020745 1359 845462 SGTC_1441 4106-0040 13 µM 0.565189153443196 0.242814461738525 no 815 0.285972556721927 1368 2904180 SGTC_2093 5331342 194.4 µM 0.564781009645193 0.242958376760026 no 816 0.286111362676743 1413 33839 SGTC_368 fentichlor 4.58 µM 0.563388020563116 0.243449904027285 no 817 0.286585346350535 1358 7329 A pesticide. SGTC_690 glyoxal 20.3 µM 0.56296896656676 0.243597875609181 no 818 0.286728008070789 1297 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1693 xanthone 101.9 µM 0.560465364728082 0.244482930071054 no 819 0.287581028852608 1439 7020 An insecticide. SGTC_1467 k284-1082 293 µM 0.559894832861672 0.244684862304629 no 820 0.287775586714773 1442 3334705 SGTC_1399 3562-5772 25 µM 0.559860246745513 0.244697106490988 no 821 0.287787382972878 1347 23847490 SGTC_2899 9053889 58.44 µM 0.559543956010509 0.244809095126061 no 822 0.287895270587598 1386 6470052 SGTC_1040 k898-0338 155 µM 0.559377884155057 0.244867907008207 no 823 0.287951925786995 1497 20969351 SGTC_3034 9090421 49.47 µM 0.55930550831776 0.244893540215337 no 824 0.287976618357393 1365 17173761 SGTC_3246 9135460 32.98 µM 0.55845800078185 0.245193807711011 no 825 0.288265838104438 1402 41446951 SGTC_2572 astragaloside iv 100 µM 0.558090223228652 0.245324170944834 no 826 0.288391388188009 1415 45006101 An anti-inflammatory agent. SGTC_743 1275-0778 158 µM 0.557914421920956 0.245386499018009 no 827 0.288451411474414 1461 2849257 YMR203W TOM40 SGTC_1418 3966-3099 2.4 µM 0.556672785407038 0.245826947344345 no 828 0.288875507073739 1444 740335 SGTC_660 4031-1742 102 µM 0.555735015779522 0.2461598854111 no 829 0.28919600774512 1360 6738706 SGTC_3016 9080866 49.47 µM 0.555171031276595 0.246360234251261 no 830 0.289388840681802 1380 17066299 SGTC_971 1315-0384 26.7 µM 0.554908091255463 0.246453670455521 no 831 0.289478763610635 1391 6769120 SGTC_2914 7968218 45.32 µM 0.553868870250688 0.246823145254082 no 832 0.289834295454262 1454 2977111 SGTC_2334 9017922 200 µM 0.55247984455423 0.24731744895488 no 833 0.290309819913055 1516 3163164 SGTC_504 lovastatin 124 µM 0.551614182872103 0.247625773913577 no 834 0.290606358590717 1374 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_3295 9122362 53.5725 µM 0.551302595231071 0.247736803118135 no 835 0.290713129866481 1399 4730473 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.551001856225605 0.247843991792519 no 836 0.290816201052235 1404 77254 SGTC_3345 9148410 3.559 µM 0.550635334370533 0.247974660097012 no 837 0.290941840848342 1429 4903596 SGTC_330 1488-0319 80.1 µM 0.550527265227187 0.248013194725154 no 838 0.29097889064343 1417 6846614 SGTC_671 0560-0003 407 µM 0.549501194741825 0.248379223732854 no 839 0.291330772446389 1417 3238678 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.549046676635113 0.24854145545973 no 840 0.291486708854549 1454 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_676 falcarinol 140 µM 0.547814887464196 0.24898140321024 no 841 0.291909507590037 1531 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2281 7943571 200 µM 0.547163702437011 0.249214148810957 no 842 0.292133135378731 1467 1244024 SGTC_294 k038-0071 157 µM 0.545187442949411 0.249921208395412 no 843 0.29281230347666 1416 24152826 SGTC_3300 9124615 50.48 µM 0.544878103189206 0.25003197924342 no 844 0.292918678554916 1486 24824903 SGTC_3266 9136860 49.47 µM 0.544826162171389 0.250050581251135 no 845 0.292936541676583 1360 4871271 YPR165W RHO1 SGTC_2496 diffractaic acid 79.83 µM 0.544561205706871 0.250145483427282 no 846 0.293027671159806 1528 94870 An apoptosis inducer which activates caspases. SGTC_2536 dehydroabietamide 32.04 µM 0.543161996683117 0.250646969158871 no 847 0.293509134967 1525 3983547 SGTC_2842 9000675 19.48 µM 0.54038761438668 0.251642898663874 no 848 0.294464873787855 1370 2989072 SGTC_477 mead ethanolamide 10 µM 0.540342622057025 0.251659066920137 no 849 0.294480384893481 1347 16061185 SGTC_2907 7721985 69.9 µM 0.538434319982195 0.252345331257897 no 850 0.295138618937112 1382 3267881 SGTC_2563 tomatine 8.54 µM 0.538136382984214 0.2524525644426 no 851 0.295241447992427 1514 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_3202 9113761 49.47 µM 0.537919129151922 0.252530773360787 no 852 0.295316440704484 1586 4798415 SGTC_2176 5809774 33.9695 µM 0.537857539748557 0.252552947170415 no 853 0.295337702022561 1436 2870539 SGTC_735 3076-0345 636 µM 0.537774911038737 0.252582697296432 no 854 0.295366227439638 1514 2888990 SGTC_1705 st027868 56.3335 µM 0.537636697364295 0.252632464686096 no 855 0.295413944956175 1471 292948 SGTC_2983 9022671 12.99 µM 0.536124808484993 0.253177196264853 no 856 0.295936147740983 1555 6405161 SGTC_865 0488-0499 301 µM 0.535612228503961 0.253362018275617 no 857 0.296113287794735 1430 9634651 SGTC_538 2922-0838 53.3 µM 0.535260672937802 0.253488820373108 no 858 0.296234808316077 1554 777039 SGTC_1626 st003712 1.76 µM 0.534956641744974 0.253598507852257 no 859 0.29633991975712 1453 24207035 SGTC_190 3970-0790 3.722 µM 0.53455667714689 0.253742843867443 no 860 0.296478223895029 1479 2832352 SGTC_3111 9122088 49.47 µM 0.534129837153231 0.253896926025754 no 861 0.296625853921674 1379 16876704 SGTC_2278 7948257 134.34 µM 0.534122501401817 0.25389957453951 no 862 0.296628391413018 1435 1247028 SGTC_23 0213-0011 39.996 µM 0.533795514291306 0.254017645319569 no 863 0.296741508800333 1492 627608 SGTC_1250 0485-0349 40.2 µM 0.533287943656873 0.254200979502934 no 864 0.296917136068216 1438 6842794 YDL195W SEC31 SGTC_672 1441-0018 53.7 µM 0.532911333297093 0.254337055748984 no 865 0.29704747978999 1388 251141 SGTC_2545 solidagenone 89.61 µM 0.530637414658659 0.255159474925634 no 866 0.297835031643676 1347 6708572 An anti ulcer agent SGTC_2059 5238311 157 µM 0.530115741979768 0.2553483467475 no 867 0.29801584261722 1409 703021 SGTC_49 0717-0965 32.132 µM 0.52963405176625 0.255522807764752 no 868 0.298182840135809 1513 5889349 YGL099W LSG1 SGTC_852 0418-0143 439 µM 0.528753806902242 0.255841780133333 no 869 0.298488122905074 1457 5369229 SGTC_842 0271-0008 11.1 µM 0.528411297779587 0.255965950542151 no 870 0.298606948876626 1500 1221709 SGTC_2019 4016004 108 µM 0.527388266784834 0.256337018823695 no 871 0.298961994894421 1394 45595336 SGTC_2674 ligustilide 100 µM 0.524662121668351 0.257327198752924 no 872 0.299909046736714 1430 5319022 A signalling regulator. SGTC_3043 9092303 49.47 µM 0.523834565688396 0.257628173271633 no 873 0.300196804790958 1375 25236084 SGTC_2133 5320837 200 µM 0.523392928882219 0.25778886729842 no 874 0.300350421964524 1496 2841355 SGTC_1214 0358-0031 63.7 µM 0.521551649848929 0.258459395478802 no 875 0.300991267499894 1640 4301366 SGTC_1645 Cervolide 78 µM 0.520601544945322 0.258805742844098 no 876 0.301322186433752 1412 23173 A fragrance. SGTC_3183 9108214 49.47 µM 0.519483706350883 0.259213542469163 no 877 0.301711736164639 1411 4974831 SGTC_2606 farnesol 9.78 µM 0.517276816436269 0.260019613810133 no 878 0.302481467697634 1535 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1720 st037298 9.481 µM 0.514745531049309 0.260945760240234 no 879 0.30336542610937 1452 597396 SGTC_1702 st027038 51 µM 0.51387142085369 0.26126597318224 no 880 0.303670944901315 1484 5521182 SGTC_725 1497-0963 19 µM 0.511658318259087 0.262077601098829 no 881 0.304445081320002 1588 3549977 SGTC_2474 5321570 43.32 µM 0.510883237508355 0.262362157586327 no 882 0.304716409683974 1525 2841384 SGTC_3329 9141233 27.5565 µM 0.510806369494274 0.262390386870009 no 883 0.304743324316754 1555 4909101 YNL103W MET4 SGTC_3 0833-0587 95.581 µM 0.510389269899518 0.262543591125172 no 884 0.304889386351111 1414 5382644 SGTC_2148 5546263 113.568 µM 0.509911936090398 0.26271897608608 no 885 0.305056579662554 1477 792097 SGTC_2965 9082772 38.63 µM 0.509520120309569 0.262862984257653 no 886 0.305193849421036 1544 16459634 SGTC_622 1348-1566 26.3 µM 0.509317583035767 0.26293744073254 no 887 0.305264817601923 1544 7340407 SGTC_2393 9031399 185.94 µM 0.508834430724031 0.263115100050262 no 888 0.305434141632244 1530 1526623 YDL150W RPC53 SGTC_1469 k284-2957 126 µM 0.508314286773576 0.263306430051926 no 889 0.305616476170177 1505 23884841 SGTC_1903 st060211 78.3 µM 0.506763579439567 0.26387726434218 no 890 0.306160356890359 1551 688960 SGTC_88 0180-0332 8.668 µM 0.506704782236573 0.26389892071767 no 891 0.306180987295954 1492 3101745 SGTC_1360 1598-0022 39.8 µM 0.506048801440738 0.264140595106563 no 892 0.30641119552423 1552 761525 SGTC_1954 st077032 68.9 µM 0.505762610112849 0.264246068130484 no 893 0.306511654730614 1390 698907 SGTC_323 4013-0906 34.3 µM 0.505392689250984 0.264382430627829 no 894 0.306641526318728 1542 2910086 SGTC_2046 4110841 106 µM 0.50212609859756 0.265588134039136 no 895 0.307789411410842 1484 44119630 YMR134W ERG29 SGTC_2978 9011784 42.97 µM 0.502020268369248 0.265627242720391 no 896 0.307826631882232 1653 2994934 SGTC_2804 7954240 19.48 µM 0.501296923603295 0.265894626942067 no 897 0.308081085034172 1560 828705 SGTC_2625 euphol 100 µM 0.501280623121102 0.26590065398243 no 898 0.308086820167161 1593 6708538 A triterpene alcohol. SGTC_2331 7980721 200 µM 0.500659181292943 0.26613048131418 no 899 0.308305502106146 1548 2981221 SGTC_556 4058-0063 51.5 µM 0.500543790782438 0.266173167163931 no 900 0.308346114880721 1511 6615692 SGTC_1339 1486-1321 22.7 µM 0.499755037018117 0.266465039803197 no 901 0.308623786979186 1479 3469382 SGTC_2602 kawain 100 µM 0.498752525472837 0.266836245479776 no 902 0.308976868137913 1453 5369129 SGTC_789 1309-1135 70.6 µM 0.496866540917026 0.267535287181512 no 903 0.309641583860182 1447 3092424 SGTC_2763 lisinopril 49.32 µM 0.496111969435278 0.26781522810455 no 904 0.309907707409732 1463 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2217 6934799 96.0675 µM 0.493623633690219 0.268739428329645 no 905 0.310786003344149 1529 675606 SGTC_2797 7859098 81.82 µM 0.493331967109488 0.268847861898518 no 906 0.310889022257632 1481 972681 SGTC_1268 0828-0275 2.46 µM 0.492614046349518 0.269114858550725 no 907 0.311142660614006 1531 745337 SGTC_1579 chlormadinone acetate 49.4 µM 0.492531625852308 0.269145519466298 no 908 0.311171785168799 1578 45114258 A steroidal progestin. SGTC_2102 5377816 72.7585 µM 0.49113520218328 0.269665263640848 no 909 0.311665412615774 1578 1379702 SGTC_1676 st018489 23.4 µM 0.490694020112379 0.26982957456956 no 910 0.311821438283801 1514 3696235 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.489515815303592 0.270268622902448 no 911 0.312238280269253 1568 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2770 toltrazuril 17.5 µM 0.488164066294383 0.270772780655837 no 912 0.312716817378077 1516 68591 Kills coccidiodes. SGTC_1878 temozolomide 1 mM 0.488098199792153 0.270797358677206 no 913 0.312740143071272 1596 5394 DNA alkylating agent. SGTC_2387 9077560 195.08 µM 0.487917699483316 0.270864717899249 no 914 0.312804068554157 1450 5303272 SGTC_150 3970-0969 77.2 µM 0.486697201442712 0.271320403467439 no 915 0.313236464378271 1542 6615640 SGTC_2184 6075246 200 µM 0.486411592601756 0.271427093619963 no 916 0.313337686472888 1526 2267320 SGTC_908 3448-7491 47.7 µM 0.485740981074141 0.271677684959709 no 917 0.313575411913781 1491 1203031 SGTC_1923 st058458 19.1 µM 0.484704414077792 0.272065251484064 no 918 0.313943017455704 1618 3534982 SGTC_2765 myclobutanil 7.74 µM 0.481986450367012 0.273082786362814 no 919 0.314907785853891 1498 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_3214 9129694 49.47 µM 0.48087488987447 0.273499468444519 no 920 0.315302710050174 1604 17158655 SGTC_103 0844-0104 51.839 µM 0.480190085839454 0.273756332207403 no 921 0.315546117900519 1544 5375804 SGTC_2567 aureobasidin a 60 nM 0.479573664197816 0.273987648349288 no 922 0.315765288267802 1593 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2514 salinomycin 42.74 µM 0.475807820496221 0.275402899353083 no 923 0.317105648911644 1649 23682228 A polyether potassium ionophore. SGTC_2130 NSC 7 2.4545 µM 0.475628723175095 0.275470295851966 no 924 0.317169454251281 1617 21448 SGTC_3237 9133362 49.47 µM 0.474651003093316 0.275838366782729 no 925 0.317517873295459 1568 43845137 SGTC_1058 3448-5425 97.3 µM 0.470880530867703 0.277260051332786 no 926 0.318863025976377 1464 7279705 SGTC_591 4299-0174 154 µM 0.469958462184165 0.277608268782792 no 927 0.319192347287166 1547 5509088 SGTC_3261 9137475 49.47 µM 0.469612236375005 0.277739075443359 no 928 0.319316040389367 1504 17027690 SGTC_916 4466-0038 42 nM 0.469181489674984 0.277901856726624 no 929 0.319469957615863 1576 5722064 YGL116W CDC20 SGTC_1726 st035556 14.5795 µM 0.466808841165663 0.278799325969142 no 930 0.3203183249091 1625 5919439 SGTC_1788 fluconazole 20 µM 0.466506036571606 0.278913965134648 no 931 0.320426663841341 1498 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_3292 9120825 59.784 µM 0.466326602377512 0.278981908167612 no 932 0.320490869921209 1636 24824900 SGTC_2863 9028737 58.44 µM 0.466261933925996 0.279006396949404 no 933 0.320514011241231 1621 6460917 SGTC_1900 st060200 72.8 µM 0.465223169540755 0.279399901586597 no 934 0.320885824064364 1529 688945 SGTC_1959 st077091 55.8 µM 0.464481387411423 0.279681068323672 no 935 0.32115144578725 1513 821356 YKL052C ASK1 SGTC_2837 9008476 45.46 µM 0.464256215605456 0.279766445102103 no 936 0.321232094751837 1571 2992805 SGTC_859 0439-0102 54.6 µM 0.463671147349762 0.279988340329042 no 937 0.321441685921809 1582 610143 SGTC_2165 5727197 32.143 µM 0.463665721864321 0.279990398418654 no 938 0.321443629779765 1615 1361712 SGTC_384 k007-0144 5.16 µM 0.460657688567749 0.281132585832074 no 939 0.322522107927361 1555 6824886 SGTC_2245 6637752 200 µM 0.460502085475504 0.281191731415969 no 940 0.322577937462584 1670 681890 SGTC_1509 1326-1131 80 µM 0.459964889134393 0.28139596884488 no 941 0.322770711300881 1578 768313 SGTC_1919 st067113 52.3 µM 0.459370525884914 0.281622024029862 no 942 0.322984055094289 1522 1268243 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.459157031187481 0.28170324420327 no 943 0.323060702200563 1564 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_478 N-arachidonylglycine 10 µM 0.458715115511824 0.281871398853223 no 944 0.323219378993646 1535 5283389 SGTC_977 1348-1378 135 µM 0.45845685353616 0.281969693273467 no 945 0.323312126924399 1505 X977 SGTC_1824 st053723 68.6 µM 0.458313123882572 0.282024403881134 no 946 0.323363748369897 1488 675225 SGTC_1740 st038286 13.222 µM 0.458177057528888 0.282076202168566 no 947 0.323412620624558 1573 716786 SGTC_148 3253-0744 288.01 µM 0.456785917525217 0.282606049618604 no 948 0.323912464391678 1506 6893655 SGTC_2201 6605497 169.863 µM 0.455289962081038 0.283176351698726 no 949 0.324450323403743 1600 670741 SGTC_3126 9127922 49.47 µM 0.455126930684759 0.283238537398189 no 950 0.32450896222163 1569 45595682 SGTC_1336 1486-0901 104 µM 0.454395294776458 0.283517688756881 no 951 0.324772169173365 1576 5006114 SGTC_2225 6654152 15.4 µM 0.452756809155076 0.284143321085012 no 952 0.325361933760909 1605 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_994 3910-0338 138 µM 0.452368974694968 0.284291506710364 no 953 0.325501596914215 1635 3479481 SGTC_1555 citronellol 128 µM 0.451402623032812 0.284660895529163 no 954 0.325849696587304 1660 8842 A terpine precursor. SGTC_2045 5106652 78.05 µM 0.448628940106361 0.28572240919217 no 955 0.32684967671026 1619 673349 SGTC_3313 9133968 57.047 µM 0.447702948386903 0.286077213435593 no 956 0.327183796765023 1536 1494643 SGTC_1301 naphtanilide LB 4.81 µM 0.447385292669999 0.286198975036889 no 957 0.327298446504683 1655 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_3049 9092223 49.47 µM 0.444276252980559 0.287392008161996 no 958 0.328421433956707 1571 8623917 SGTC_1835 st008666 49.2 µM 0.44408721987584 0.287464621715971 no 959 0.328489763000523 1511 690455 SGTC_1796 st049173 110.4 µM 0.443610282592907 0.287647866860416 no 960 0.328662185111187 1593 94134 SGTC_3076 9116187 49.47 µM 0.441975562656286 0.288276364809482 no 961 0.329253444823957 1677 27241210 SGTC_522 1273-0010 11.6 µM 0.441352800449339 0.288515967358283 no 962 0.329478803350382 1608 5705015 SGTC_749 1000-0129 128 µM 0.440459182966732 0.288859943055483 no 963 0.329802284293912 1693 708470 SGTC_1649 st011737 51.3 µM 0.440403396260054 0.288881423152254 no 964 0.329822482771117 1553 1761035 SGTC_1050 3232-1156 69.3 µM 0.440192538638735 0.288962618497069 no 965 0.329898831657087 1526 700529 SGTC_1948 st076329 66.6 µM 0.440092643539443 0.28900108904084 no 966 0.329935004887161 1503 24208413 SGTC_1652 st011932 78 µM 0.440058392020542 0.289014280178106 no 967 0.329947408144755 1637 1551076 SGTC_1499 4480-0877 67.3 µM 0.439970924141369 0.289047967583957 no 968 0.329979083110592 1571 2861909 SGTC_2946 9065502 71.43 µM 0.437112572260698 0.290149849080772 no 969 0.331014855017595 1502 16489101 SGTC_3144 9087057 49.47 µM 0.437033451754639 0.290180377647433 no 970 0.331043544114191 1715 17249618 SGTC_3269 9137823 49.47 µM 0.436878153483383 0.290240303702859 no 971 0.331099858153928 1541 17682936 SGTC_235 0330-0087 5 mM 0.435088494422965 0.290931310228419 no 972 0.331749097240411 1558 46494818 YHR062C RPP1 SGTC_2682 pyrogallin 40.03 µM 0.434154426765826 0.291292268835954 no 973 0.332088152263416 1602 822798 An ATP competetive kinase inhibitor. SGTC_1329 1447-1697 50.6 µM 0.432831957999686 0.291803677294219 no 974 0.332568427226603 1569 2840515 SGTC_2429 5902844 64.44 µM 0.432337702581054 0.291994916849459 no 975 0.332747994346701 1691 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2124 5246320 200 µM 0.431264885464448 0.292410216799149 no 976 0.333137889761484 1613 579342 SGTC_127 0180-0333 59.125 µM 0.431026235289382 0.292502638375918 no 977 0.333224647272272 1570 771601 SGTC_1990 st072050 59.8 µM 0.425645140966014 0.294590158791048 no 978 0.33518322098373 1549 17233948 SGTC_651 3253-0966 34.4 µM 0.423940211555463 0.295252993349042 no 979 0.335804708575672 1559 781462 SGTC_365 0121-0052 13.6 µM 0.422805233964093 0.295694624922944 no 980 0.336218684317706 1626 3101739 SGTC_673 1082-0474 110 µM 0.422622498421109 0.295765757585161 no 981 0.336285354509051 1578 3098046 SGTC_2874 9043904 71.43 µM 0.422001912721342 0.296007388921407 no 982 0.336511810667053 1585 4463428 SGTC_963 1269-2853 151 µM 0.421860507199369 0.296062459269471 no 983 0.336563418852778 1547 3668223 SGTC_3215 9129942 49.47 µM 0.42130506650723 0.296278821016604 no 984 0.336766165523386 1679 17682944 SGTC_1226 3909-7979 35.4 µM 0.421210425058074 0.296315694088637 no 985 0.336800716228349 1699 6615510 SGTC_3305 9127027 53.8275 µM 0.420183315100811 0.296715999678426 no 986 0.337175771262537 1597 41905295 SGTC_2204 7233102 200 µM 0.418909691671383 0.297212724972823 no 987 0.337641066902298 1627 2172480 SGTC_837 0091-0265 12.5 µM 0.418720330565195 0.297286610055749 no 988 0.337710267829798 1564 759367 SGTC_2034 5197015 53.07 µM 0.417515954373785 0.297756730935865 no 989 0.338150528531269 1697 780676 SGTC_1596 piperlongumine 63 µM 0.41742027746151 0.297794092369859 no 990 0.338185512806131 1698 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1358 1509-0022 2.48 µM 0.417136477966079 0.297904927461455 no 991 0.338289292344794 1599 3258434 SGTC_530 4358-1714 28 µM 0.416523286717095 0.298144467446701 no 992 0.33851356550055 1663 1564641 SGTC_2973 9094665 17.96 µM 0.415984389277935 0.298355057349557 no 993 0.338710713182197 1717 25237061 YIL048W NEO1 SGTC_2887 9044784 58.44 µM 0.41334050725536 0.299389210926868 no 994 0.339678577908333 1572 6465546 SGTC_898 1000-0849 28.3 µM 0.41258150049169 0.299686396207991 no 995 0.339956628683132 1636 6751807 SGTC_3332 9141069 11.198 µM 0.412274156223116 0.299806773309918 no 996 0.340069244437685 1554 17332883 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.411830703152313 0.299980498529734 no 997 0.340231757736647 1671 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1114 scopoletin 1.73284 µM 0.411800211889901 0.299992445325803 no 998 0.340242933032845 1717 5280460 A coumarin with genotoxic properties. SGTC_3205 9113483 49.47 µM 0.411731128555258 0.300019513696503 no 999 0.340268253157168 1726 17018033 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.411396414190729 0.30015067779411 no 1000 0.340390941411312 1607 6857784 SGTC_539 4859-0462 2.54 µM 0.411087524071082 0.300271745179862 no 1001 0.340504178879121 1733 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_596 1155-0152 116 µM 0.410991194237142 0.300309505519208 no 1002 0.340539495823587 1592 280313 SGTC_2349 9023730 187.07 µM 0.408148971005068 0.30142459319729 no 1003 0.341582154566517 1706 4126287 SGTC_1113 artemisinin 1.17947 µM 0.407132517355207 0.301823829761929 no 1004 0.341955330872063 1733 2240 An anti-malaria and mitochondrial poison. SGTC_2155 5570423 76 µM 0.406459893476528 0.302088149530013 no 1005 0.342202359979959 1621 797402 SGTC_1927 st060202 13.8 µM 0.405747303048113 0.302368288202694 no 1006 0.342464140961025 1722 688887 SGTC_1838 st055369 84.5 µM 0.405275138325295 0.302553973152061 no 1007 0.342637639590089 1588 676036 SGTC_877 0771-0151 33.1 µM 0.403045763770112 0.303431393344692 no 1008 0.343457279258592 1641 6166523 SGTC_2482 5981709 142.65 µM 0.402691103025127 0.303571082757251 no 1009 0.343587739910026 1652 877755 SGTC_951 1171-0579 82.7 µM 0.402475282916069 0.303656101378888 no 1010 0.343667137664271 1548 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2329 6138490 200 µM 0.402329107412363 0.303713690742172 no 1011 0.343720917881104 1639 720019 SGTC_2080 5212524 12.4 µM 0.400778586178206 0.304324855770718 no 1012 0.344291573021727 1743 260183 SGTC_3240 9133527 49.47 µM 0.400776923782659 0.304325511326758 no 1013 0.344292185041753 1611 17617455 SGTC_81 0411-0046 9.971 µM 0.400355026150651 0.304491904535343 no 1014 0.344447522145287 1581 12925265 SGTC_1744 st037937 38.9 µM 0.399612599078683 0.304784810366749 no 1015 0.344720937632283 1679 1016152 SGTC_2888 9058547 12.99 µM 0.399035312309586 0.305012650781878 no 1016 0.344933592558556 1566 16476514 SGTC_1531 st059297 52.4 µM 0.398878003695039 0.305074749605913 no 1017 0.34499154877474 1651 7566702 SGTC_763 3453-1109 128 µM 0.397403313711658 0.305657167933135 no 1018 0.345535036142779 1738 1560353 SGTC_1079 idarubicin 2.36 µM 0.395700287407081 0.306330378265944 no 1019 0.346163071726134 1659 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_76 0433-0009 400.328 µM 0.39506267448904 0.306582596638447 no 1020 0.346398317210315 1628 2841569 SGTC_1091 telmisartan 47.6 µM 0.394723661087314 0.306716736336827 no 1021 0.346523419384323 1705 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1194 1488-0194 225 µM 0.393671560901086 0.307133192640449 no 1022 0.346911770229971 1633 1391452 SGTC_2403 6032726 181.2 µM 0.393611693364012 0.307156897695498 no 1023 0.346933873355111 1612 2881040 SGTC_168 3970-0862 530.542 µM 0.392275498485784 0.307686184880162 no 1024 0.347427332603871 1655 3135186 SGTC_2686 alizarin 95.37 µM 0.390418540682006 0.308422419185251 no 1025 0.348113540020452 1578 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1784 st039334 36.3 µM 0.390175506743915 0.308518832793927 no 1026 0.3482033859831 1747 3496984 SGTC_3107 9121808 49.47 µM 0.390131683082854 0.308536219414502 no 1027 0.348219587833068 1716 662681 SGTC_1877 wortmannin 25 µM 0.39008034456441 0.308556588029319 no 1028 0.348238568319718 1739 312145 A covalent inhibitor of PI 3-kinase. SGTC_3170 9103054 49.47 µM 0.389933374570212 0.308614901796749 no 1029 0.348292907049895 1601 16432970 SGTC_2526 patulin 37.61 µM 0.389921262286392 0.30861970784271 no 1030 0.348297385423471 1688 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2772 vinpocetine 57.06 µM 0.389700096542165 0.308707470197338 no 1031 0.348379162558076 1690 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_3339 9145883 14.936 µM 0.388382560072243 0.309230517525959 no 1032 0.34886647417505 1717 2030670 SGTC_3342 9147791 14.508 µM 0.386610846391564 0.309934477961807 no 1033 0.349522163473604 1636 1838168 SGTC_2745 rifampicin 24.3 µM 0.385524718810968 0.310366377377522 no 1034 0.349924348090701 1763 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_567 1080-0542 68.4 µM 0.385005364124367 0.310572991643615 no 1035 0.350116720655747 1730 5950415 SGTC_22 0964-0034 14.468 µM 0.383746795970752 0.311073934164393 no 1036 0.350583062479615 1623 138402 SGTC_1921 5740136 50 µM 0.381287724693375 0.312053717867114 no 1037 0.351494880610774 1796 1774243 SGTC_2063 5246145 200 µM 0.381158219722193 0.312105354327386 no 1038 0.351542924514645 1691 711240 SGTC_2172 5754775 163.918 µM 0.380580215441386 0.312335862255324 no 1039 0.351757382114537 1604 2263357 SGTC_3315 9136395 68.55 µM 0.379264978180104 0.312860652138052 no 1040 0.3522455518532 1788 16876844 SGTC_2617 dihydrotanshinone i 20.83 µM 0.376690893322827 0.313888829420601 no 1041 0.353201665635297 1624 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_3260 9137109 49.47 µM 0.375574819614476 0.314335077452763 no 1042 0.353616506773341 1758 17478346 SGTC_770 0389-1121 67.2 µM 0.37543043374651 0.314392828171359 no 1043 0.353670187268082 1788 6753108 SGTC_1067 clotrimazole 1.36 µM 0.374686551340519 0.314690434407561 no 1044 0.353946797656603 1661 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1497 4476-2978 41.3 µM 0.374379839136452 0.314813176325851 no 1045 0.354060870106065 1674 1528379 SGTC_1637 st007924 17.4 µM 0.373952746190032 0.314984127007624 no 1046 0.354219736397749 1630 683336 SGTC_1658 st012944 20 µM 0.373515058614892 0.315159359487248 no 1047 0.354382569913342 1723 24207260 SGTC_2950 9072895 21.46 µM 0.373058923792166 0.315342021770699 no 1048 0.354552294713055 1607 17332245 SGTC_1098 clofazimine 15.1 µM 0.372336238103048 0.315631518568481 no 1049 0.354821260477225 1730 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1049 3226-0134 66 µM 0.37110086576344 0.316126651785028 no 1050 0.355281203107196 1668 5702385 SGTC_2014 4013930 200 µM 0.370550040469088 0.316347527182679 no 1051 0.355486349407841 1723 64556 SGTC_1430 4049-0248 69.1 µM 0.369178889431815 0.316897629420307 no 1052 0.355997195000343 1763 22774488 SGTC_2610 ononetin 44.17 µM 0.36878843971463 0.317054350977138 no 1053 0.3561427110205 1624 259632 SGTC_1820 st053765 18.6 µM 0.366671640791394 0.317904577932074 no 1054 0.356931981360789 1634 3690829 SGTC_454 lyso-paf C-16 6.67 µM 0.366507195755686 0.317970668696886 no 1055 0.35699332208407 1574 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2544 sphondin 68.51 µM 0.366238125275936 0.318078821125775 no 1056 0.357093697804817 1764 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_53 0973-0023 39.979 µM 0.364641680021637 0.318720828476273 no 1057 0.357689448887935 1853 674768 SGTC_2064 5220758 200 µM 0.364587447527007 0.318742647541306 no 1058 0.357709693118394 1700 788518 SGTC_1687 st020778 55.3625 µM 0.363541252474021 0.319163680420487 no 1059 0.358100301354552 1704 4259299 SGTC_2258 7960471 200 µM 0.362616463019293 0.319536048928141 no 1060 0.358445705235754 1661 2974708 SGTC_3128 9127691 49.47 µM 0.362477980531829 0.319591824885236 no 1061 0.358497437678057 1690 41316314 SGTC_2955 9076254 12.21 µM 0.361993320038733 0.319787061499852 no 1062 0.358678511129261 1816 16459619 SGTC_234 nsc-17383 10.7 µM 0.36135707683927 0.320043436241823 no 1063 0.358916265445762 1772 408974 SGTC_933 2914-0560 114 µM 0.361290198802745 0.32007038979857 no 1064 0.358941259918031 1844 463887 SGTC_1974 st069448 26.9 µM 0.359442402421394 0.320815474117252 no 1065 0.359632079346573 1804 6323587 YNR016C ACC1 SGTC_2382 9035899 200 µM 0.356809224389432 0.321878494444927 no 1066 0.36061731508282 1685 6462679 SGTC_2273 7815444 169.05 µM 0.353726869245396 0.323124702615954 no 1067 0.361771792039774 1816 2824616 SGTC_2767 sibutramine 71.45 µM 0.353413872917025 0.32325135965403 no 1068 0.361889093466612 1818 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2418 pentamidine 31.67 µM 0.352439963714732 0.323645592592599 no 1069 0.362254167734005 1627 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3137 9097352 49.47 µM 0.35183948993882 0.323888759685091 no 1070 0.362479320522151 1764 44120435 SGTC_70 0141-0289 43.283 µM 0.351360785044452 0.324082669272224 no 1071 0.362658849108508 1775 352408 SGTC_214 4373-3496 70 µM 0.350399847000492 0.324472061693517 no 1072 0.363019320599404 1779 3779166 SGTC_2271 7849410 118.62 µM 0.350157544147703 0.324570278259925 no 1073 0.363110233533824 1852 972430 SGTC_72 0744-0168 198.391 µM 0.350018190007378 0.324626770473183 no 1074 0.36316252322143 1738 677577 SGTC_731 3966-0296 387 µM 0.349303621116103 0.324916510042771 no 1075 0.363430690104641 1702 660956 SGTC_97 0535-0701 19.132 µM 0.349285368639685 0.324923912347481 no 1076 0.363437540859946 1630 2832013 YGL099W LSG1 SGTC_1128 3448-9350 235 µM 0.345614580975379 0.326414004287773 no 1077 0.364816193248606 1682 619386 SGTC_1749 st037932 54.2 µM 0.344419736010399 0.32689963037421 no 1078 0.365265324297759 1683 594497 SGTC_2717 st081029 62.2815 µM 0.344131928099098 0.327016649274748 no 1079 0.365373536249762 1825 5292846 SGTC_43 0570-0105 72.5 µM 0.344053589065414 0.327048503838178 no 1080 0.365402992542029 1718 1114046 YDL195W SEC31 SGTC_1815 st051655 58.2 µM 0.341987554470071 0.327889058166387 no 1081 0.366180129148923 1819 5984156 SGTC_2229 7354935 190 µM 0.341544935847677 0.328069248659802 no 1082 0.366346691193174 1768 318112 SGTC_2692 st077426 47.7 µM 0.339607818851756 0.328858321359637 no 1083 0.367075944582436 1819 25238571 SGTC_265 mycophenolic acid 32.932 µM 0.339432406742098 0.328929812151299 no 1084 0.367142004530248 1816 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_27 0485-0001 32.618 µM 0.339204891562405 0.329022547343602 no 1085 0.367227692278299 1810 2054479 SGTC_2294 7971431 200 µM 0.338713378825505 0.329222923866852 no 1086 0.367412830495072 1758 5741572 SGTC_633 0437-0093 97.7 µM 0.338311123407232 0.329386949095909 no 1087 0.367564371075159 1699 2831118 SGTC_3263 9137018 49.47 µM 0.336477345945174 0.330135112971354 no 1088 0.368255466017696 1624 43844957 SGTC_2162 5663267 200 µM 0.336362202931995 0.33018211294442 no 1089 0.368298874170782 1816 6456493 SGTC_1500 4488-1866 171 µM 0.335772767018357 0.330422755451492 no 1090 0.368521113926031 1816 2900003 SGTC_475 α-linolenic acid 10 µM 0.334537281747266 0.330927380901099 no 1091 0.368987081509854 1797 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2343 7990716 14.84 µM 0.334128293482098 0.331094497096393 no 1092 0.369141375331638 1757 6456862 SGTC_1180 1193-0155 285 µM 0.334041349368768 0.331130027562867 no 1093 0.369174178354425 1694 2921347 SGTC_2974 9094440 9.66 µM 0.332341225396582 0.331825103218367 no 1094 0.369815806930889 1811 25236134 SGTC_1200 1643-0193 18.4 µM 0.332227934995088 0.331871441276857 no 1095 0.369858575753439 1823 5403974 SGTC_1374 2889-5571 141 µM 0.330835869845672 0.3324410337723 no 1096 0.370384232452514 1703 2853281 SGTC_2252 omeprazole 400 µM 0.330590536075441 0.332541457367009 no 1097 0.370476897881082 1816 4594 A proton pump inhibitor. SGTC_1211 1056-0033 32.3 µM 0.329738179099057 0.332890449932325 no 1098 0.370798901445066 1850 6741922 SGTC_1448 4255-0083 152 µM 0.32928072170771 0.333077812917041 no 1099 0.37097175711471 1859 5399660 SGTC_2840 9008771 71.43 µM 0.327625598563966 0.333756057398715 no 1100 0.371597382219712 1895 2992978 SGTC_2475 5812728 15.03 µM 0.325925539639508 0.334453281843159 no 1101 0.372240346013144 1693 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1077 5-fluorocytosine 377 nM 0.325771340321546 0.334516550028664 no 1102 0.372298681984124 1753 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2924 9010168 62.78 µM 0.325724132531632 0.33453592038748 no 1103 0.372316542002286 1729 2993929 SGTC_3001 9076041 71.4286 µM 0.325209122140391 0.334747268692537 no 1104 0.372511402571237 1730 16004211 SGTC_163 TUB2.036 7.546 µM 0.325052869946256 0.334811401320579 no 1105 0.372570528982435 1791 15992207 YJR013W GPI14 SGTC_2690 usnic acid 100 µM 0.323744075098941 0.335348776128098 no 1106 0.373065899621085 1878 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1534 6-azauridine 81.6 µM 0.323739280985465 0.335350745151421 no 1107 0.373067714549336 1748 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2077 5212015 200 µM 0.322796976946357 0.335737853080083 no 1108 0.373424501302667 1701 780900 SGTC_1558 st069300 45.6 µM 0.321846649258532 0.336128433818927 no 1109 0.373784435999441 1854 24208000 SGTC_1799 st045822 46.1415 µM 0.321516151570294 0.3362643084979 no 1110 0.373909637152149 1858 3674992 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.319433526089589 0.337121011928071 no 1111 0.374698895631186 1725 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_511 blebbistatin 171 µM 0.319108902094945 0.337254624684029 no 1112 0.374821966699758 1836 3476986 A myosin inhibitor. SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.318059791012481 0.337686571093415 no 1113 0.375219791587978 1827 140250 A respiratory chain inhibitor. SGTC_2666 tannic acid 100 µM 0.31752275608293 0.33790776519679 no 1114 0.375423487641146 1773 16134267 A thiamine antagonist. SGTC_1 0258-0098 57.368 µM 0.31690873365528 0.338160737530318 no 1115 0.375656427427585 1755 6790032 YDR047W HEM12 SGTC_541 4513-1321 94 µM 0.316476808827441 0.338338730903592 no 1116 0.375820312575942 1714 747515 SGTC_728 3030-5151 22.5 µM 0.315855108416438 0.338594992965616 no 1117 0.376056243559092 1775 3125388 SGTC_111 0083-0039 52.457 µM 0.315268030123216 0.33883705257501 no 1118 0.376279078225752 1772 759313 SGTC_3110 9122132 49.47 µM 0.314812014154757 0.339025119515844 no 1119 0.376452194621952 1857 918317 SGTC_2052 5265182 7.135 µM 0.314463718058966 0.339168788403121 no 1120 0.376584434289146 1851 1239884 SGTC_1868 st057644 42.7 µM 0.311574681533895 0.340361388880844 no 1121 0.377681889118756 1737 688665 SGTC_1721 st082152 9.2685 µM 0.311283377820029 0.34048172858118 no 1122 0.377792601298285 1735 5296051 SGTC_1075 aripiprazole 15.2 µM 0.310865401159636 0.340654426175896 no 1123 0.377951474024386 1748 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2819 7996655 46.38 µM 0.31065104340415 0.34074300644922 no 1124 0.378032959313519 1846 6456960 SGTC_2086 5274770 176.623 µM 0.310093601061913 0.340973402622802 no 1125 0.378244889103795 1751 689278 SGTC_2747 doxorubicin 7.63 µM 0.309978737529231 0.341020884176756 no 1126 0.378288562756378 1865 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2680 butyl paraben 22.24 µM 0.30975318673834 0.341114128249073 no 1127 0.378374326674041 1789 7184 An antifungal and steroid mimetic. SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.307279129136264 0.34213755465869 no 1128 0.379315460138238 1814 2724278 An inhibitor of dopamine biosynthesis. SGTC_2326 6164455 177.58 µM 0.307125321358056 0.342201217664185 no 1129 0.379373992423781 1746 2888790 SGTC_1508 1080-0625 72.9 µM 0.30661901438048 0.342410816269462 no 1130 0.379566689490597 1788 767111 SGTC_2428 5615643 7.78 µM 0.305608472719239 0.342829300686343 no 1131 0.379951384324424 1806 2253075 SGTC_2028 5153890 36.43 µM 0.305539073703325 0.342858047216649 no 1132 0.37997780763214 1747 2830968 YPR165W RHO1 SGTC_899 1083-0020 478 µM 0.305439647213402 0.342899233342884 no 1133 0.380015664717878 1883 767123 SGTC_2219 9098279 200 µM 0.30489293811386 0.343125733799702 no 1134 0.380223847212426 1874 902349 SGTC_3258 9138477 49.47 µM 0.301696700521033 0.344451054384841 no 1135 0.381441641878727 1807 4970355 SGTC_2153 5569715 200 µM 0.300966477022581 0.344754110609957 no 1136 0.381720028739805 1798 2054701 SGTC_2720 fluspirilene 36.88 µM 0.300222082597378 0.345063150600409 no 1137 0.382003881036561 1837 3396 An atypical antipsychotic. SGTC_142 0335-0849 62.6745 µM 0.299958168228955 0.345172741128205 no 1138 0.382104532038927 1797 3889043 YPR107C YTH1 SGTC_3213 9129884 49.47 µM 0.298947622122085 0.345592490713919 no 1139 0.382490005201515 1673 17190742 SGTC_333 3486-0131 40.1 µM 0.297573426619371 0.346163593668106 no 1140 0.38301437936127 1910 6744690 SGTC_1383 3049-0032 20.7 µM 0.297225935062696 0.346308063446597 no 1141 0.383147011383627 1902 712864 SGTC_2212 7123476 200 µM 0.297141707701124 0.346343084380141 no 1142 0.383179161696504 1843 1085715 SGTC_3109 9122853 49.47 µM 0.297020641810382 0.346393424723943 no 1143 0.383225375004247 1841 1234709 SGTC_874 0599-0792 117 µM 0.296888762052357 0.346448264663952 no 1144 0.383275718075701 1939 765305 SGTC_1983 st071813 46.9 µM 0.295226781359223 0.347139646429885 no 1145 0.383910322352445 1796 11838595 SGTC_2487 5918373 44.05 µM 0.292548657670602 0.348254812714218 no 1146 0.384933581351629 1912 2876279 SGTC_106 0092-0003 11.579 µM 0.292230542706769 0.348387362703301 no 1147 0.385055180317205 1907 1072148 SGTC_856 0433-0016 11.3 µM 0.292213782087747 0.348394346918199 no 1148 0.385061587352168 1797 3911780 SGTC_2743 auranofin 4.32 µM 0.292021501523458 0.348474474651347 no 1149 0.385135092150301 1857 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_3125 9127534 49.47 µM 0.291160654703759 0.348833292177181 no 1150 0.385464226274151 1867 1639235 SGTC_2879 9041815 71.43 µM 0.290795051333897 0.348985723633781 no 1151 0.385604035170371 1883 4942971 SGTC_2570 licareol 100 µM 0.290764938036986 0.348998279893927 no 1152 0.385615551336472 1759 443158 SGTC_598 3937-0236 20.2 µM 0.289891426236388 0.349362577660699 no 1153 0.385949650501453 1860 1379313 SGTC_2398 5228213 48.84 µM 0.287973223457736 0.350163050124986 no 1154 0.386683617712469 1977 80771 YMR134W ERG29 SGTC_1912 st060209 90.8 µM 0.287657941978244 0.350294681983372 no 1155 0.386804293605724 1729 688787 SGTC_1641 st009299 47.1 µM 0.285188073994864 0.35132648746718 no 1156 0.387750028360711 1865 4046054 SGTC_2376 9072922 81.32 µM 0.283022652559774 0.352232010809192 no 1157 0.388579736200193 1843 17087968 SGTC_2876 9059903 25.97 µM 0.281617341813045 0.352820124448238 no 1158 0.389118470678278 1820 6916095 SGTC_415 dibenzyl ketone 100 µM 0.281266946199087 0.352966817650313 no 1159 0.389252830234739 1928 7593 SGTC_3068 9116768 49.47 µM 0.281201809425155 0.352994089585141 no 1160 0.389277808457419 1795 41904888 SGTC_1553 gossypol 38.6 µM 0.280171354940629 0.353425628101974 no 1161 0.389673021187993 1847 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1100 amiodarone 5.07 µM 0.27776917112736 0.354432356868089 no 1162 0.390594779049568 1972 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2529 gangaleoidin 93.61 µM 0.277294557260681 0.354631382955365 no 1163 0.390776969223181 1815 4565183 SGTC_810 3825-7150 143 µM 0.276139931955713 0.355115732842918 no 1164 0.391220295651767 1984 22330411 YGL099W LSG1 SGTC_2002 4023503 131 µM 0.276039098762553 0.355158042150227 no 1165 0.391259017978615 2005 4736863 YCR052W RSC6 SGTC_1240 0356-0016 42.1 µM 0.275654879523775 0.35531927575977 no 1166 0.391406577112685 1843 4305613 SGTC_2744 captopril 92.04 µM 0.27557620338949 0.355352294577512 no 1167 0.391436794556379 1935 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1017 4239-0030 168 µM 0.273734980700025 0.356125328907224 no 1168 0.392144146700525 1741 1149593 SGTC_2521 angolensin 13.4 µM 0.272605174590347 0.356599969330392 no 1169 0.392578366903063 1855 821428 A flavenoid. SGTC_1797 st048695 56.8 µM 0.271081638106092 0.35724037065696 no 1170 0.393164121839109 1929 592262 YIL048W NEO1 SGTC_491 tetrandrine 80.3 µM 0.269529320745917 0.357893283534235 no 1171 0.393761191034654 1919 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2426 5582046 32.21 µM 0.267995025851243 0.358539024843765 no 1172 0.394351573766943 1876 2251934 SGTC_3158 9100007 49.47 µM 0.267732420815283 0.358649588481744 no 1173 0.394452646169394 1771 19297233 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.26672387427296 0.35907432319343 no 1174 0.394840885310336 1855 165521 SGTC_620 0109-0052 432 µM 0.26455572803747 0.359987995848876 no 1175 0.395675864535792 1942 493037 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.264296162353185 0.360097432480005 no 1176 0.395775858588685 1796 5282362 SGTC_2177 5811945 192 µM 0.263880079967702 0.360272882726614 no 1177 0.39593616282311 1915 5343475 SGTC_1085 doxorubicin 7.67 µM 0.263839782522339 0.360289876590423 no 1178 0.395951689172038 1939 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2073 5212005 126 µM 0.262428270425333 0.360885300292421 no 1179 0.396495639780552 1985 691789 SGTC_3019 9081971 49.47 µM 0.262393135567529 0.360900125676366 no 1180 0.396509182180706 1965 16451803 SGTC_2851 9015922 71.43 µM 0.261492530835994 0.361280213039624 no 1181 0.396856354367701 1917 2996893 SGTC_1215 3852-0577 11.2 µM 0.261379502792574 0.361327924592498 no 1182 0.3968999310863 1938 2884876 SGTC_3236 9132701 49.47 µM 0.260990147064293 0.361492296475226 no 1183 0.397050052756333 1803 24282524 SGTC_1977 st070720 65.3 µM 0.25995000329827 0.36193153279661 no 1184 0.397451169819934 1831 682188 SGTC_2008 4012253 172 µM 0.258457612682511 0.362562063489411 no 1185 0.398026878993681 1824 603940 SGTC_1470 k295-0292 231 µM 0.257113044053424 0.363130459255991 no 1186 0.39854575413433 1935 5045612 SGTC_1812 st052057 4.327 µM 0.256263287275775 0.363489836511032 no 1187 0.398873771711568 1820 3645418 SGTC_1463 k081-0032 34.1 µM 0.256160137669868 0.363533468498997 no 1188 0.398913593717188 1862 977755 SGTC_1216 1165-0504 9.65 µM 0.256128716814155 0.363546759782776 no 1189 0.398925724282788 1973 6304004 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.25280413536186 0.364954010633981 no 1190 0.400209785963759 1734 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1409 3909-8004 61.9 µM 0.251297483366831 0.365592357070752 no 1191 0.400792060366661 1874 2119279 SGTC_1263 0774-1208 64.8 µM 0.250385109884844 0.365979097552475 no 1192 0.401144771774917 1991 906585 SGTC_1529 apigenin 74 µM 0.24866035094618 0.366710567064828 no 1193 0.401811760490806 1981 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_280 3448-3607 3.04 µM 0.247496214412391 0.367204550803645 no 1194 0.402262110426355 1987 626179 SGTC_2722 naftopidil 47.16 µM 0.24747661166638 0.367212870817362 no 1195 0.40226969492387 1942 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_455 paf C-16 10 µM 0.246484104683066 0.367634202999778 no 1196 0.402653753786222 1863 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2878 9043973 25.97 µM 0.246088953353277 0.367801994284814 no 1197 0.402806687064779 1966 6465167 SGTC_1662 st014054 52 µM 0.245473974212059 0.368063180220602 no 1198 0.403044728686255 1958 2838777 SGTC_2419 paclitaxel 166.5 µM 0.243957204839398 0.368707623309276 no 1199 0.40363198211139 1871 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_752 1896-0090 130 µM 0.243420969082345 0.368935546967783 no 1200 0.403839650636572 1851 772567 SGTC_3020 9089140 49.47 µM 0.241962458337313 0.369555710848563 no 1201 0.40440462644082 1852 17217859 SGTC_1861 st057647 17.4 µM 0.240241584597852 0.370287868946657 no 1202 0.405071488813678 1997 688668 SGTC_1779 st039427 55 µM 0.239419096967603 0.370637968458298 no 1203 0.405390311653472 2056 1124498 SGTC_1254 0550-0035 264 µM 0.236526232562128 0.371870192545621 no 1204 0.406512177011664 1945 15121435 SGTC_2033 5192550 145 µM 0.235904772415968 0.372135077165424 no 1205 0.406753282452932 1845 182073 SGTC_2667 digitoxin 100 µM 0.235222131737884 0.372426108475759 no 1206 0.407018164601858 2016 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_805 3852-0218 479 µM 0.233763406521482 0.373048253198192 no 1207 0.407584329937204 1832 6615355 SGTC_258 haloperidol 50.781 µM 0.232735110759882 0.37348701936064 no 1208 0.407983551647424 1835 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2564 betulinic acid 100 µM 0.23235197169153 0.373650543937733 no 1209 0.408132324585449 2073 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2655 perillic acid 100 µM 0.232029706032578 0.373788105229574 no 1210 0.408257470628919 1875 5702197 An apoptosis inducer. SGTC_826 1683-5028 118 µM 0.231395568637445 0.374058838030296 no 1211 0.408503753737059 1896 722377 SGTC_2664 lyso-paf C-16 73.48 µM 0.230628789187877 0.374386282790003 no 1212 0.408801599965315 1920 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1233 0325-0408 14.2 µM 0.2302467644076 0.374549456122967 no 1213 0.408950012553457 1963 12874 SGTC_453 enantio-paf c16 10 µM 0.230133263117227 0.374597939988986 no 1214 0.408994109121217 1955 13871343 A lipid and platelet activating factor SGTC_2436 5633522 8.09 µM 0.228763839862452 0.375183066785794 no 1215 0.409526236567933 2026 5724242 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.228377444263029 0.375348217826306 no 1216 0.409676411511554 1852 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_501 nsc-95397 161 µM 0.226554547166267 0.376127657988265 no 1217 0.410385069675374 1990 262093 SGTC_444 curcumin 90.4 µM 0.226211482927822 0.376274403110144 no 1218 0.410518469996553 1957 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1013 4112-3890 241 µM 0.225222585575087 0.376697502231598 no 1219 0.410903060013423 1875 705171 SGTC_607 4491-0986 66.8 µM 0.224969143855701 0.376805960984414 no 1220 0.411001639311696 2019 698981 YDR232W HEM1 SGTC_1982 st072467 71.9 µM 0.2244766371463 0.377016753860824 no 1221 0.411193221970108 1868 3163533 SGTC_3139 9095020 49.47 µM 0.224287350464618 0.377097778317971 no 1222 0.411266859184327 2002 25236292 SGTC_1845 st056753 3.01 µM 0.223354289185411 0.377497255666862 no 1223 0.411629888805181 1817 5375839 SGTC_490 phenamil 164 µM 0.223011445587232 0.37764407239305 no 1224 0.411763299263311 2011 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_912 3474-0017 2.18 µM 0.222470586465324 0.377875721714756 no 1225 0.411973784079186 1970 3360550 SGTC_937 3122-0005 46.7 µM 0.221557455803961 0.378266914132104 no 1226 0.412329202342854 2030 759535 SGTC_1522 st012842 45.6 µM 0.221223697269643 0.378409930105007 no 1227 0.412459129290207 1814 3491067 YOR116C RPO31 SGTC_1762 st045503 25.4615 µM 0.219916457458405 0.378970244312658 no 1228 0.412968109430426 1868 4645554 SGTC_2116 5511452 16.8835 µM 0.219763701852488 0.379035735638578 no 1229 0.413027595129554 1942 870744 SGTC_604 1000-0114 314 µM 0.219172268188082 0.379289335334915 no 1230 0.413257928543191 2014 1572745 SGTC_2228 7354201 200 µM 0.218599581418701 0.379534946097309 no 1231 0.413480989447285 1986 753451 SGTC_1507 4075-3230 155 µM 0.217830393738152 0.3798649075824 no 1232 0.413780631184151 2046 659771 SGTC_1002 4049-0206 172 µM 0.216917078261866 0.380256809729481 no 1233 0.414136483969897 1878 4662749 SGTC_1460 k062-0059 9.15 µM 0.211471504954296 0.382596035508602 no 1234 0.416259682584517 1860 1373085 SGTC_2112 5488546 200 µM 0.21086677699165 0.382856071467004 no 1235 0.416495614662295 1944 600757 SGTC_3041 9091929 49.47 µM 0.210850156133539 0.38286321926285 no 1236 0.416502099645576 1988 25236887 SGTC_2411 st077133 39.94 µM 0.20934625460968 0.38351013655857 no 1237 0.417088972840946 2063 1403142 YNL221C POP1 SGTC_1213 1315-0166 115 µM 0.208894873301953 0.383704365917425 no 1238 0.417265153194686 1809 768401 SGTC_1403 3909-7815 62.9 µM 0.208490251246911 0.383878499612199 no 1239 0.417423096888536 1937 6615483 SGTC_707 0865-0008 204 µM 0.208215369260349 0.383996811574051 no 1240 0.417530404317512 1974 723043 SGTC_3203 9113543 49.47 µM 0.208019037181812 0.384081321487895 no 1241 0.417607051479875 1950 17018012 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.208012466210277 0.384084150016793 no 1242 0.417609616811827 2068 551469 SGTC_1340 1486-1359 257 µM 0.207610615280775 0.384257141792782 no 1243 0.417766507583256 1948 4309068 SGTC_1153 4055-0057 267 µM 0.20726300783816 0.384406801029994 no 1244 0.417902231154268 1886 882706 SGTC_533 1222-0222 6.71 µM 0.207027296252266 0.384508294324975 no 1245 0.417994270473763 2026 3982874 SGTC_465 cgp-37157 41 µM 0.205906760411957 0.384990885667994 no 1246 0.418431872279931 2057 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_7 0192-1582 4.227 µM 0.204714187429679 0.385504697656034 no 1247 0.418897717594784 1971 252616 SGTC_33 0986-0033 35.816 µM 0.204628932251886 0.385541436980684 no 1248 0.418931024511802 2045 2848082 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.203821639772288 0.385889377335349 no 1249 0.419246440854166 2020 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_956 1185-0240 191 µM 0.203167743641491 0.386171271699335 no 1250 0.419501961937038 1953 1416193 SGTC_291 SEC14.278 35.5 µM 0.202787869004536 0.386335063114787 no 1251 0.419650420036755 2037 1068044 SGTC_1563 conessine 56.1 µM 0.202550659782358 0.386437351432948 no 1252 0.419743129133139 2053 441082 An anti-amoebic, histamine inhibitor. SGTC_2976 9009005 19.48 µM 0.20220839264424 0.386584956271017 no 1253 0.419876906137019 2079 2993148 SGTC_2719 novobiocin 32.65 µM 0.201264185708244 0.386992236420148 no 1254 0.420246002597338 2048 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_41 0478-0632 82.643 µM 0.200679219610254 0.387244621838751 no 1255 0.420474704754641 2112 3750424 SGTC_2749 bexarotene 57.39 µM 0.200621103444324 0.387269698841945 no 1256 0.420497427697015 1906 82146 An retinoic acid receptor inhibitor. SGTC_1081 sertraline 6 µM 0.200347283845004 0.387387857750601 no 1257 0.420604492469405 2067 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1879 gemcitabine 100 µM 0.199825897243728 0.387612875858349 no 1258 0.420808373356728 1979 60750 A nucleoside analog which inhibits DNA replication. SGTC_197 4544-0043 41.561 µM 0.199754545072449 0.387643672704025 no 1259 0.42083627627205 2065 896523 SGTC_1056 3448-1962 115 µM 0.198637309639541 0.388125983142209 no 1260 0.421273233125848 1970 715507 SGTC_1206 3978-0017 132 µM 0.197559368698122 0.388591493772674 no 1261 0.421694913621907 1993 3873677 SGTC_1916 st067606 49.2 µM 0.196620626402199 0.388997021638071 no 1262 0.422062214077879 2020 19590279 SGTC_325 2810-4341 181 µM 0.194426510905432 0.389945330009964 no 1263 0.422920966636045 2065 774970 SGTC_298 1391-0729 10 µM 0.192449300701572 0.390800452411327 no 1264 0.423695138844574 1936 3237558 SGTC_1335 1486-0900 202 µM 0.192068988852569 0.390964993956748 no 1265 0.423844082970682 2040 X1335 SGTC_2 0422-0095 29 µM 0.19126843187392 0.391311417903638 no 1266 0.424157646097899 1993 6790840 SGTC_107 0358-0022 2.6945 µM 0.190838556203822 0.391497473028525 no 1267 0.424326040147817 2059 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_487 nimodipine 119 µM 0.189631252682487 0.392020140489708 no 1268 0.424799047724094 2086 4497 L-type voltage-gated calcium channels inhibitor SGTC_804 1595-0054 20.9 µM 0.188322654914152 0.392586880500031 no 1269 0.425311863510836 1950 761523 Stimulates phospholipase C. SGTC_440 fluspirilene 35.1 µM 0.187795024727837 0.39281545613925 no 1270 0.42551866803628 2028 3396 An atypical antipsychotic. SGTC_1259 0671-0132 43 µM 0.187005564901911 0.393157528491401 no 1271 0.42582813487863 1935 X1259 SGTC_128 0906-2981 13.371 µM 0.186605439156993 0.393330934201079 no 1272 0.425985000915469 2083 6740226 SGTC_2549 cedrol 20.94 µM 0.186313421491624 0.393457501604024 no 1273 0.426099491455763 2071 6708665 A sedative which affects the nervous system. SGTC_1876 myriocin 605 nM 0.184919769699889 0.394061698317642 no 1274 0.426645982214611 2095 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2769 toremifene 3.73 µM 0.182860417454385 0.394954965945322 no 1275 0.427453770726229 2000 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2698 st077697 67.5 µM 0.182606628009613 0.395065088353126 no 1276 0.427553341696572 1917 3154499 SGTC_2806 7952793 58.44 µM 0.182094294659232 0.395287421721205 no 1277 0.427754363042083 2005 2972490 SGTC_944 3370-0224 231 µM 0.181242930516819 0.395656957039792 no 1278 0.428088449438579 1950 4580514 SGTC_2121 5257820 149.641 µM 0.180887359496407 0.395811320732571 no 1279 0.428227995421517 2113 791256 SGTC_2951 9072950 58.06 µM 0.179830283952222 0.396270324307457 no 1280 0.4286429040083 2113 16488155 SGTC_2759 disulfiram 3.38 µM 0.179401862484251 0.396456394565348 no 1281 0.428811084530904 1983 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_954 1189-0853 2.85 µM 0.178569381212305 0.396818021828252 no 1282 0.429137919132649 2090 2828194 SGTC_2741 miltefosine 3.04 µM 0.178026544660259 0.397053876156031 no 1283 0.429351064548992 2016 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_432 NS 1619 61.3 µM 0.177757601990602 0.397170741661263 no 1284 0.429456672842156 1980 4552 A K+/calcium channel activator. SGTC_2628 lathosterol 100 µM 0.176835818113304 0.397571360734778 no 1285 0.429818676805592 2001 6710616 SGTC_2159 5658611 73.75 µM 0.176581000195998 0.39768212694644 no 1286 0.429918759598605 2094 793844 SGTC_2515 chrysin 20.77 µM 0.17632490689427 0.397793455863601 no 1287 0.430019347851427 2068 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.175846058084396 0.398001643413473 no 1288 0.430207442130121 1944 4174840 SGTC_2378 9074213 121.43 µM 0.175728953037233 0.398052561218735 no 1289 0.43025344400775 2087 657714 SGTC_2279 7948423 32.93 µM 0.175403172212566 0.398194221329142 no 1290 0.430381424081711 2110 1247112 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.174776959915336 0.39846655650011 no 1291 0.43062744649234 1953 61125 An anti-inflammatory. SGTC_1688 st021091 57.6 µM 0.17412129223613 0.398751754601052 no 1292 0.430885070007248 2119 3656366 SGTC_3167 9103034 49.47 µM 0.172209659157405 0.399583572555772 no 1293 0.431636352208785 2080 5127859 SGTC_2911 7942208 15.64 µM 0.172145913728223 0.399611318283393 no 1294 0.431661408785934 1956 1243384 SGTC_2237 6667747 47.222 µM 0.172083250185089 0.399638593605254 no 1295 0.431686040371398 1937 729940 YDL015C TSC13 SGTC_1681 tripelennamine 100 µM 0.170387026783326 0.400377087949003 no 1296 0.43235288704479 2131 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_474 dl-dihydrosphingosine 5 µM 0.169987309397173 0.400551167134303 no 1297 0.432510058516683 2084 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2742 clothiapine 36.27 µM 0.169734033971939 0.400661480242929 no 1298 0.432609653587561 2114 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2088 5278280 127.392 µM 0.168994948907167 0.400983431080146 no 1299 0.432900307222839 2024 791502 SGTC_104 0074-0074 590.992 µM 0.16739387367445 0.401681101502388 no 1300 0.433530072633483 2116 3943124 SGTC_590 k048-0076 22.4 µM 0.166595072680858 0.40202929733587 no 1301 0.433844335474579 2112 6832814 SGTC_938 3126-1755 342 µM 0.16610131011386 0.402244566410679 no 1302 0.434038611578738 2137 1777771 SGTC_2036 5160441 105 µM 0.166014658232869 0.402282347689734 no 1303 0.434072707322607 2035 134534 YIL048W NEO1 SGTC_1932 st074806 40.9 µM 0.165132580463233 0.402666996263659 no 1304 0.434419814759997 2044 17251235 SGTC_3356 9151811 4.48 µM 0.16508464431811 0.402687902531654 no 1305 0.434438679618542 1997 1859254 YPR165W RHO1 SGTC_1752 st044819 83.042 µM 0.164432074677128 0.40297253370992 no 1306 0.434695507632374 1987 441209 YML126C ERG13 SGTC_3341 9147222 25.867 µM 0.16411890161067 0.403109148618109 no 1307 0.434818771116366 2026 1939759 SGTC_2576 guaiol 23.12 µM 0.163988997150618 0.40316582007225 no 1308 0.434869902776352 2142 227829 SGTC_2783 7738165 71.43 µM 0.163254262316024 0.403486389977881 no 1309 0.435159122037893 1936 17201110 SGTC_996 3970-0799 1.8 µM 0.162277188676089 0.403912794425878 no 1310 0.435543788685981 2108 6615648 YGL040C HEM2 SGTC_2227 7312221 64.1025 µM 0.161738349256151 0.404147998086774 no 1311 0.435755951888293 2108 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2905 7799065 20.05 µM 0.161623769232108 0.404198016792055 no 1312 0.435801069134047 2115 1296806 SGTC_880 0833-0487 87.2 µM 0.160928438913507 0.404501589497332 no 1313 0.436074881607198 1990 76075 SGTC_2242 6630449 61.2675 µM 0.160332523031499 0.404761804840974 no 1314 0.43630957029337 2034 691249 YDR170C SEC7 SGTC_2670 beta-carotene 100 µM 0.160304989261572 0.404773828881348 no 1315 0.436320414420592 2102 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_3165 9101544 49.47 µM 0.159395349954778 0.405171120278881 no 1316 0.436678701136975 2074 5002184 SGTC_3047 9092122 49.47 µM 0.158430041962289 0.40559283226291 no 1317 0.437058971324588 2002 17173831 SGTC_892 0929-0076 29 µM 0.157783042699076 0.405875546791811 no 1318 0.437313880617078 1986 5751038 SGTC_3102 9121669 49.47 µM 0.155537570260381 0.406857114420752 no 1319 0.438198768768533 2020 41905072 SGTC_2128 5255449 168.493 µM 0.154411139945215 0.407349733921955 no 1320 0.438642785297077 2064 736008 SGTC_1506 4226-2149 212 µM 0.154229300759031 0.407429271047561 no 1321 0.438714469958985 2048 991114 SGTC_139 0099-0334 718.624 µM 0.154161142120759 0.407459084868979 no 1322 0.438741339982221 2165 97690 SGTC_1766 st045414 44.774 µM 0.153899980040444 0.407573326848155 no 1323 0.438844299921044 2102 253960 SGTC_1928 4'-methoxychalcone 40.3 µM 0.151483559909911 0.408630730255724 no 1324 0.439797139236143 2171 641818 SGTC_2358 9037157 4 µM 0.150043500815482 0.409261203957503 no 1325 0.440365147513164 2063 2388925 SGTC_3327 9140648 26.9345 µM 0.149068153745327 0.409688355092195 no 1326 0.44074992735539 2130 8029710 SGTC_1277 0873-0036 22 µM 0.148400200648468 0.409980945590127 no 1327 0.441013470865385 2111 5965735 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.14821045682514 0.410064070215876 no 1328 0.441088339803582 2055 521171 SGTC_1421 4029-0249 71.4 µM 0.148177084328969 0.410078690747523 no 1329 0.44110150810933 2165 2894095 SGTC_2988 9073640 71.4286 µM 0.147631836691489 0.410317582099708 no 1330 0.441316664177256 2084 9102229 SGTC_976 1348-1067 47.6 µM 0.146920474839301 0.410629303707644 no 1331 0.441597395354729 2102 5310671 YGL099W LSG1 SGTC_2938 9059746 27.26 µM 0.146582567601313 0.410777395802086 no 1332 0.441730757039503 2082 6471769 SGTC_2920 7982904 15.77 µM 0.145769676461104 0.411133707627864 no 1333 0.442051607420682 2041 6456808 SGTC_305 1682-2595 20.8 µM 0.145719097158154 0.411155880308893 no 1334 0.442071572470057 2077 226033 SGTC_492 tmb-8 126 µM 0.144976268048329 0.411481550369638 no 1335 0.442364804582459 2146 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_911 3456-4043 236 µM 0.144468263736452 0.411704304019208 no 1336 0.44256535769751 2100 914281 SGTC_2194 5927483 104.545 µM 0.144304402070346 0.411776161420516 no 1337 0.44263005117156 2140 760979 SGTC_343 4130-2827 29.8 µM 0.14337043205121 0.412185786842245 no 1338 0.442998816755471 2016 1118244 SGTC_3044 9093193 49.47 µM 0.142916619111876 0.41238485704866 no 1339 0.443178016577818 2008 25236277 SGTC_249 wiskostatin 11.211 µM 0.141503807747569 0.413004746927462 no 1340 0.443735976081969 2143 2775510 A n-wasp and actin depolymerizer. SGTC_3323 9138564 53.9225 µM 0.140933293483879 0.413255129277332 no 1341 0.443961320118368 2144 43912313 YNL103W MET4 SGTC_105 0111-0055 734.78 µM 0.140834024687927 0.413298699111855 no 1342 0.444000531562456 2092 5179370 SGTC_973 1325-0077 65.9 µM 0.140707435455236 0.413354261644143 no 1343 0.444050535448495 2112 2835149 SGTC_554 4483-2211 187 µM 0.140254840961374 0.413552928555697 no 1344 0.44422932162567 2052 747107 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.14009475225367 0.413623204992837 no 1345 0.444292563399662 2144 88881 An O-methylated flavonoid and antioxidant. SGTC_531 3788-1495 174 µM 0.138859085110908 0.414165736465311 no 1346 0.44478075150765 2009 2896655 SGTC_2532 xanthone 78.9 µM 0.138253766499863 0.414431567240474 no 1347 0.445019931759495 2131 7020 An insecticide. SGTC_557 1315-0110 16.2 µM 0.138195629430902 0.41445710068994 no 1348 0.445042904582607 2136 6833801 SGTC_472 calcifediol 10 µM 0.137632274891103 0.414704541307937 no 1349 0.445265523292709 2073 5283731 A vitamin D metabolite. SGTC_4 0960-0234 25.671 µM 0.137285140893822 0.414857028850351 no 1350 0.445402707537992 2053 6821112 SGTC_3340 9146634 11.102 µM 0.136522789549356 0.415191956294211 no 1351 0.445704004880673 2056 4907387 SGTC_2516 gossypol 71.55 µM 0.135926775203088 0.415453849059588 no 1352 0.445939584182359 2146 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2709 st078560 56 µM 0.135803164720389 0.415508169054974 no 1353 0.445988444578529 2171 17250903 SGTC_1123 mangostin 811.285 nM 0.135050002171982 0.41583917734672 no 1354 0.446286170202093 2015 5281650 An antioxidant. SGTC_79 0052-0007 94.094 µM 0.134511805750585 0.416075746520916 no 1355 0.446498938144168 2148 2801472 SGTC_1623 st003709 20.3 µM 0.133020885507431 0.416731252747333 no 1356 0.447088431517869 2017 16192618 SGTC_1855 st056195 39.6 µM 0.132303620512426 0.417046692060159 no 1357 0.447372071898373 2201 4028379 SGTC_2269 7935389 174.42 µM 0.130941756239579 0.417645760515221 no 1358 0.447910691166241 2088 97605 SGTC_1899 st063254 59.6 µM 0.13061425218083 0.417789854358156 no 1359 0.448040233854688 2011 3093813 SGTC_513 4245-1575 41.7 µM 0.130422821610788 0.417874084278994 no 1360 0.448115955882426 2135 719745 SGTC_379 3970-0972 5.9 µM 0.130213661096614 0.417966119725682 no 1361 0.448198693305078 2080 2898042 YBL034C STU1 SGTC_1320 1313-0481 95.3 µM 0.129792120971031 0.418151620742689 no 1362 0.448365448369171 2163 6813365 YLR208W SEC13 SGTC_3066 9117245 49.47 µM 0.129284428898498 0.41837505755825 no 1363 0.448566295983178 2125 17176980 SGTC_2964 9083345 53.42 µM 0.129209137067105 0.418408195965457 no 1364 0.448596083242102 2065 17741579 SGTC_724 3910-0327 137 µM 0.12893787657523 0.418527591414905 no 1365 0.44870340281679 2062 2885483 SGTC_833 3852-0053 558 µM 0.128294901067325 0.418810627389792 no 1366 0.44895780006008 2122 3123681 SGTC_3239 9133757 49.47 µM 0.128123177774532 0.418886226608661 no 1367 0.449025746999995 2116 17036923 SGTC_1218 1348-1416 30.7 µM 0.126636140581168 0.419541002741116 no 1368 0.44961419557862 2127 6787668 SGTC_96 0929-0093 37.281 µM 0.124530810429902 0.420468407945239 no 1369 0.450447503523549 2045 6991579 SGTC_1203 3992-3522 103 µM 0.124425356634952 0.420514872363946 no 1370 0.450489248827473 2218 5322312 SGTC_2431 5490079 200 µM 0.123427257642102 0.42095470351751 no 1371 0.450884386808812 2086 5722345 SGTC_1427 4048-4900 550 nM 0.123232097763994 0.421040715950963 no 1372 0.450961654466714 2202 24132586 SGTC_3083 9117465 49.47 µM 0.12322009072407 0.421046007913424 no 1373 0.450966408352147 2022 16420915 SGTC_2584 androsterone 48.74 µM 0.121427030055239 0.421836438047064 no 1374 0.451676404196966 2204 2754130 A steroid. SGTC_627 1391-0720 175 µM 0.121230664137087 0.421923020703529 no 1375 0.45175416838123 2102 997839 SGTC_947 3447-0010 211 µM 0.121057131000657 0.421999538955545 no 1376 0.451822891943433 2188 748350 SGTC_2397 5161689 200 µM 0.120698990756436 0.422157467758111 no 1377 0.451964729205988 2143 2259942 SGTC_1627 st003713 25.6 µM 0.119613550762369 0.422636189675923 no 1378 0.452394642420658 2076 16195070 YER133W GLC7 SGTC_421 streptovitacin 30 mM 0.118724423904074 0.4230284149298 no 1379 0.45274684296219 2068 91467 include heat shock SGTC_906 1165-0455 526 µM 0.118452818848364 0.423148244743701 no 1380 0.452854438464124 2186 3252859 SGTC_199 4063-0024 41.6 µM 0.118222494133733 0.423249867597773 no 1381 0.452945683599505 2176 306215 SGTC_3219 9131112 49.47 µM 0.118096507744786 0.42330545691717 no 1382 0.452995595252837 2205 17612988 YMR079W SEC14 SGTC_1691 st019933 84.6 µM 0.117508530033006 0.423564912105174 no 1383 0.453228542443394 2216 6176082 SGTC_2760 etidronate 98.04 µM 0.115658682687844 0.424381404435753 no 1384 0.453961526430575 2136 3305 A chelator and antioxidant. SGTC_1657 st012939 43.4 µM 0.115599350921685 0.424407597897447 no 1385 0.453985038673949 2180 24207257 SGTC_3105 9121040 49.47 µM 0.115510629236777 0.424446766881624 no 1386 0.454020197979543 2211 41448907 SGTC_2336 9001819 198.65 µM 0.115018380600691 0.424664099100924 no 1387 0.454215276559305 2161 2989602 SGTC_1683 st010134 710 nM 0.114862834919952 0.424732778689348 no 1388 0.454276921752015 2140 3818134 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.11430845512029 0.424977577933192 no 1389 0.45449664010884 2200 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1204 4049-0315 18.3 µM 0.114302399344789 0.424980252161078 no 1390 0.454499040282387 2154 588402 SGTC_2054 5233173 129 µM 0.113069255754815 0.42552487960432 no 1391 0.454987824501669 2131 6889 SGTC_2595 hexamethylquercetagetin 100 µM 0.112974070673931 0.425566924756621 no 1392 0.455025556093922 2120 386331 SGTC_2877 9040724 71.43 µM 0.110713582058275 0.426565675438552 no 1393 0.455921737635946 2219 6463895 SGTC_2675 theaflavin digallate 100 µM 0.110320955764453 0.426739197534789 no 1394 0.456077419202377 2179 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1712 st032288 53.4 µM 0.109688050842499 0.427018941162296 no 1395 0.456328388638558 2164 2883011 SGTC_3264 9137442 49.47 µM 0.109476546218487 0.42711243427989 no 1396 0.456412261675132 2217 17015726 SGTC_1971 st069429 63.5 µM 0.107325494007036 0.428063513142634 no 1397 0.457265380028796 2220 1246522 YGL099W LSG1 SGTC_1255 0566-0045 221 µM 0.107322333285708 0.428064910951472 no 1398 0.457266633732992 2132 2788469 SGTC_2097 5376186 200 µM 0.107050514183393 0.428185124589882 no 1399 0.457374452720463 2197 742755 SGTC_2800 7887935 81.82 µM 0.10565376645432 0.428802949582958 no 1400 0.457928531988729 2127 2961002 SGTC_987 1497-1013 404 µM 0.10369347267976 0.429670342517934 no 1401 0.458706303389058 2214 1676435 SGTC_1060 3448-7350 82 µM 0.103304764650742 0.429842378952192 no 1402 0.45886054710469 2216 570178 SGTC_2024 5144227 134 µM 0.103174668412559 0.429899960603411 no 1403 0.45891217213905 2181 3475211 SGTC_2825 7998094 58.44 µM 0.102935075940316 0.430006010077616 no 1404 0.459007249487908 2154 2987815 SGTC_1228 0124-0032 52.5 µM 0.102279380731387 0.430296262574338 no 1405 0.459267460630373 2177 X1228 SGTC_189 3970-0742 2.116 µM 0.102222269819868 0.430321545289827 no 1406 0.459290125792653 2235 2891807 SGTC_2302 7771753 200 µM 0.101641261170094 0.430578771137134 no 1407 0.459520713674275 2111 2203047 SGTC_2884 9058502 51.95 µM 0.101032957088979 0.430848112862173 no 1408 0.459762149024675 2144 6471554 SGTC_1574 spiramycin 23.7 µM 0.100722806046392 0.430985452321265 no 1409 0.459885253415621 2211 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1084 voriconazole 435 nM 0.100412325740824 0.43112294594229 no 1410 0.460008492348697 2228 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_320 4092-0846 5.34 µM 0.099873477829363 0.431361590064101 no 1411 0.460222386338503 2209 1359356 SGTC_284 0988-0104 32.6 µM 0.0998422199395679 0.431375434279309 no 1412 0.460234794413741 2207 4666532 SGTC_3249 9135183 49.47 µM 0.0994362277787633 0.431555257104338 no 1413 0.460395959839003 2177 4902779 SGTC_2126 5251174 33.877 µM 0.0962297987975751 0.432975950241173 no 1414 0.461669032306164 2245 790722 SGTC_2224 6650123 117.647 µM 0.095867894046115 0.433136356483578 no 1415 0.461812746969707 2208 2908370 SGTC_3193 9111931 49.47 µM 0.0955709506387002 0.433267978282224 no 1416 0.461930668797956 2162 17087244 SGTC_1028 k015-0029 4.8 µM 0.0950921522424305 0.433480223889311 no 1417 0.462120815716564 2237 4588309 SGTC_2724 maprotiline 69.64 µM 0.0931521886526442 0.434340382284362 no 1418 0.462891328544616 2217 4011 A tricyclic antidepressant. SGTC_667 1498-1044 59 µM 0.0926876519190215 0.43454639902928 no 1419 0.463075853560048 2166 6739982 SGTC_2960 9079389 5.97 µM 0.0913801086050941 0.435126374832814 no 1420 0.463595283323587 2253 16457355 SGTC_2484 5809818 12.04 µM 0.0913737598609471 0.435129191232507 no 1421 0.463597805554054 2187 2870548 SGTC_3181 9108277 49.47 µM 0.0913171195210774 0.435154317896413 no 1422 0.463620307705442 2201 17097298 SGTC_227 fluconazole 33.516 µM 0.0901255025767494 0.435683000951968 no 1423 0.464093741778899 2106 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_154 3389-1638 511.116 µM 0.0900643069371928 0.435710154649092 no 1424 0.464118056424261 1990 5238686 SGTC_2838 9002687 71.43 µM 0.0885128898922384 0.436398649506925 no 1425 0.464734519948649 2127 6457060 SGTC_703 3875-0075 71.8 µM 0.0881253070589206 0.436570682937391 no 1426 0.464888541250777 2179 2850814 SGTC_3238 9133470 49.47 µM 0.0881188146512688 0.436573564775024 no 1427 0.464891121309498 2253 3534688 SGTC_895 0964-0006 13.7 µM 0.0878826705150436 0.436678386274526 no 1428 0.464984965115736 2239 6738897 SGTC_398 bronopol 33.3 µM 0.0874995246410757 0.436848469507507 no 1429 0.465137231632481 2144 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1437 4092-1038 11.6 µM 0.0869486942928281 0.437093010418697 no 1430 0.465356146800787 2229 3977136 SGTC_1312 1218-2183 165 µM 0.0863917181649034 0.43734030418676 no 1431 0.465577515132241 2258 6744073 SGTC_566 0958-0068 16.5 µM 0.08610659303277 0.437466907365744 no 1432 0.465690841305411 2230 6815365 SGTC_519 k048-0011 62.8 µM 0.0853021712836468 0.437824126594106 no 1433 0.466010582696016 2148 6836379 SGTC_3212 9128307 49.47 µM 0.0852930287798239 0.437828186793741 no 1434 0.466014216783036 1980 27243542 SGTC_2371 9071574 200 µM 0.0847019818688028 0.438090685482973 no 1435 0.466249160164298 2251 45596039 SGTC_883 0850-0245 24.6 µM 0.0842745190735203 0.438280549365517 no 1436 0.466419085575479 2200 6823229 YPR165W RHO1 SGTC_3317 9138495 8.753 µM 0.0838985769142238 0.43844754134356 no 1437 0.466568535515451 2265 17020139 SGTC_52 0329-0193 875 nM 0.0836877948633176 0.438541174670071 no 1438 0.466652330694912 2228 3739292 SGTC_358 0075-0058 9.45 µM 0.0831934555258342 0.438760782928355 no 1439 0.466848858217795 2305 1069125 SGTC_3141 9094609 49.47 µM 0.0824219774581981 0.439103546598849 no 1440 0.467155580011224 2103 25236309 YDL196W YDL196W SGTC_786 4544-0069 423 µM 0.0792299896096262 0.440522212664209 no 1441 0.468424845652447 2193 748821 YLR208W SEC13 SGTC_2953 9074162 66.49 µM 0.075169701770817 0.442327892585633 no 1442 0.470039845307762 2286 16451992 SGTC_2987 9018338 71.43 µM 0.0750067620125273 0.442400379971995 no 1443 0.470104665871578 2292 5055682 SGTC_929 2805-0021 398 µM 0.0749297860326836 0.442434625124688 no 1444 0.470135288669712 2158 3098024 SGTC_2546 rhodinyl acetate 100 µM 0.0747194139136438 0.442528217881731 no 1445 0.470218980390944 2283 6708682 SGTC_3282 9108498 15.4605 µM 0.0744032462882287 0.442668884186246 no 1446 0.470344762900366 2190 16459645 SGTC_863 0466-0191 129 µM 0.0739393318884468 0.442875297663849 no 1447 0.470529329582653 2283 765160 YPR165W RHO1 SGTC_3011 9081274 71.4286 µM 0.073929403106502 0.442879715533018 no 1448 0.470533279782326 2206 6625322 SGTC_1548 st061468 90.8 µM 0.0733210426922239 0.443150422559357 no 1449 0.470775323559622 2273 390799 SGTC_984 1492-0255 2.91 µM 0.073157077686743 0.443223387931846 no 1450 0.470840560932578 2208 1585198 SGTC_1951 sophoraflavanone G 9.2 µM 0.0724541404439421 0.443536220845937 no 1451 0.471120250062255 2247 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_773 4358-1457 44.6 µM 0.0707432269728099 0.444297786926041 no 1452 0.471801058424539 2286 1186886 SGTC_1023 4482-3888 16 µM 0.0691363987403081 0.445013209698569 no 1453 0.472440524162954 2282 3303168 SGTC_2598 perillyl alcohol 100 µM 0.0688279887592801 0.445150546447214 no 1454 0.472563269551288 2225 10819 An apoptosis inducer. SGTC_3285 9112818 20.8695 µM 0.0672269275613227 0.445863613695276 no 1455 0.473200524258539 2288 17017947 YPR165W RHO1 SGTC_1160 4092-0570 10.5 µM 0.0670633497221171 0.445936476525138 no 1456 0.473265635433227 2242 4994975 SGTC_3178 9107506 49.47 µM 0.0668617776631308 0.446026265713218 no 1457 0.473345870960717 2253 8897194 SGTC_1341 1486-1360 280 µM 0.0665376400446708 0.446170656871894 no 1458 0.473474895835145 2277 3976547 SGTC_99 0109-0120 622.8 µM 0.0661894858909774 0.44632575444764 no 1459 0.473613483731159 2276 759414 SGTC_117 lucigenin 22.078 µM 0.065941873623543 0.446436067084338 no 1460 0.473712051390791 2077 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2893 9048488 25.97 µM 0.0657765464517754 0.446509723563591 no 1461 0.473777864504682 2218 6467338 SGTC_2683 piperine 63.03 µM 0.0634324098173365 0.447554279557558 no 1462 0.474711089952916 2250 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_395 anisomycin 6.25 µM 0.0629355360441112 0.447775735335593 no 1463 0.474908918625426 2185 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3174 9107204 49.47 µM 0.0622269781115074 0.448091566519816 no 1464 0.475191039344974 2265 3938802 SGTC_2929 9013348 24.6 µM 0.0601641836376606 0.449011219007538 no 1465 0.476012435666997 2249 2995952 SGTC_2006 4011487 200 µM 0.0597221795642534 0.449208312819004 no 1466 0.476188453262425 2286 45595294 SGTC_2079 5212404 121 µM 0.0581494770960341 0.449909697077736 no 1467 0.476814782006838 2302 758462 SGTC_1591 genipin 88.4 µM 0.0571246225470964 0.450366839820568 no 1468 0.477222961244711 2287 442424 A DNA cross-linking agent. SGTC_1686 st019653 115.5 µM 0.0561421131843107 0.450805156072003 no 1469 0.477614297677047 2308 97252 SGTC_2925 9010536 32.5 µM 0.0561010679510746 0.450823468446302 no 1470 0.477630646589173 2245 2994177 SGTC_641 4092-0595 30 µM 0.055781278073163 0.450966146621007 no 1471 0.47775802482609 2270 786260 SGTC_381 3461-2219 42.7 µM 0.055740797343378 0.450984208047055 no 1472 0.47777414921352 2311 2883159 SGTC_1880 MG-132 525 µM 0.0554057965710785 0.451133680382296 no 1473 0.477907588968665 2300 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1275 0867-0008 21.1 µM 0.0551646797308539 0.451241267400707 no 1474 0.478003633779858 2254 3422836 SGTC_3307 9126885 69.2785 µM 0.0548686352717845 0.451373368176508 no 1475 0.478121559824712 2287 24824909 SGTC_760 0568-0725 82.9 µM 0.0547395391035777 0.451430975076047 no 1476 0.478172984459759 2313 3916171 SGTC_505 gw-5074 63.9 µM 0.0540244110623866 0.451750106908105 no 1477 0.478457857711665 2277 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_362 0310-0100 9.03 µM 0.0537356925506223 0.451878958791171 no 1478 0.478572872663867 2262 790235 SGTC_878 0828-0289 13.7 µM 0.0525485053128667 0.452408840474551 no 1479 0.479045823522142 2289 745350 YLR208W SEC13 SGTC_3095 9117207 49.47 µM 0.0520993064169304 0.45260935524141 no 1480 0.479224782808215 2308 17015229 SGTC_1116 jasmonic acid  1.58368 µM 0.0512223119607795 0.453000865475871 no 1481 0.479574186403037 2305 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1136 pergolide 1.05886 µM 0.0499484347760816 0.453569634457076 no 1482 0.480081740037754 2223 47811 A dopamine receptor agonist. SGTC_416 estradiol valerate 100 µM 0.0498519174247068 0.45361273204896 no 1483 0.480120196980753 2219 13791 A steroid. SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.0496959375633014 0.453682382404571 no 1484 0.480182346908116 2310 688667 SGTC_2314 7727897 200 µM 0.0481578141499256 0.454369283194216 no 1485 0.480795235292537 2291 900724 SGTC_2151 5563267 85.4165 µM 0.0480830143103438 0.454402691077418 no 1486 0.480825041581783 2247 5310824 SGTC_64 000l-0018 272.079 µM 0.0478822985039973 0.454492338454237 no 1487 0.480905023477558 2304 6811119 SGTC_1094 duloxetine 25.4 µM 0.0473864443758602 0.454713815852076 no 1488 0.481102616352539 2321 60834 A selective serotonin reuptake inhibitor. SGTC_2390 9097792 176.6 µM 0.0460475684756106 0.455311906121276 no 1489 0.481636167967244 2234 4497149 SGTC_2320 7373003 200 µM 0.0457815712108796 0.455430742066371 no 1490 0.481742173725494 2283 5415828 SGTC_2605 digitonin 300 nM 0.044760712033522 0.455886854231694 no 1491 0.48214902047097 2330 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_414 piperonyl butoxide 100 µM 0.04382900564151 0.456303184369976 no 1492 0.482520353067817 2315 5794 A potent inhibitor of cytochrome P450. SGTC_1495 4469-0029 237 µM 0.0436784717052009 0.456370454510811 no 1493 0.482580349963377 2320 793680 SGTC_2468 5987765 72.9 µM 0.0435422603407295 0.456431325302707 no 1494 0.482634638786161 2249 26772094 SGTC_1306 1185-0270 9.02 µM 0.0429419349516343 0.456699613773959 no 1495 0.482873910153419 2312 1548076 SGTC_2555 cholic acid 100 µM 0.0420139983060834 0.457114352176246 no 1496 0.483243769468097 2263 6708657 Influences liver metabolism. SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.0412368515954736 0.457461731448275 no 1497 0.483553537661008 2316 4330530 SGTC_2869 9037858 32.47 µM 0.0400991688755651 0.457970326398138 no 1498 0.484007032205745 2347 27187042 SGTC_597 k018-0003 82.8 µM 0.0397539743760191 0.458124657393281 no 1499 0.484144635163593 2320 6786234 SGTC_1792 st045773 43.6 µM 0.0396512408339332 0.458170589153433 no 1500 0.484185587627781 2317 2919270 SGTC_2556 citropten 84.59 µM 0.0395887845864236 0.458198513367614 no 1501 0.484210484517025 2328 2775 A potential DNA crosslinker. SGTC_3232 9132874 49.47 µM 0.0389976888946259 0.458462802693649 no 1502 0.484446115604283 2331 3784940 SGTC_1246 0422-0085 105 µM 0.0388635280126335 0.458522790955206 no 1503 0.484499597508705 2327 264295 SGTC_675 1309-0189 238 µM 0.038694676004084 0.458598292237011 no 1504 0.48456690908273 2303 4246530 SGTC_821 1114-0266 29.2 µM 0.0383722134384754 0.458742483813921 no 1505 0.484695457561921 2305 3123235 SGTC_512 prima-1 270 µM 0.0382464496167585 0.458798721531206 no 1506 0.484745593264513 2339 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1327 1436-0082 2.18 µM 0.037813420136572 0.45899236531181 no 1507 0.484918222151821 2200 15992205 SGTC_1640 st009078 66.4 µM 0.0338956404718432 0.460744769725837 no 1508 0.486480184795879 2342 690618 SGTC_2175 5807670 165.306 µM 0.0337462598070979 0.460811602303819 no 1509 0.486539744984963 2338 241186 SGTC_694 1315-0438 43.2 µM 0.033157619355175 0.46107496949327 no 1510 0.486774447189389 2314 6793154 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.0324212686906599 0.46140444862764 no 1511 0.487068050720034 2336 6728940 SGTC_2543 pimpinellin 60.67 µM 0.032024688535432 0.461581908886173 no 1512 0.487226181194128 2349 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1572 epiandrosterone 68.9 µM 0.0310497436337741 0.462018206162178 no 1513 0.487614934546729 2312 441302 A steroid. SGTC_1970 st070122 35.8 µM 0.0298918590948121 0.46253643003187 no 1514 0.48807664922555 2331 102928 SGTC_2463 5473429 200 µM 0.0296775594826476 0.462632349163998 no 1515 0.488162104488028 2256 5399405 SGTC_1212 0520-0165 585 µM 0.0294476973972535 0.462735236374537 no 1516 0.488253766129799 2344 5403258 SGTC_696 1560-0013 611 µM 0.0292338343613277 0.462830964584048 no 1517 0.488339048420048 2330 1650269 SGTC_1524 corynanthine 62.1 µM 0.0271540710921209 0.463762008331375 no 1518 0.489168424071505 2278 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2263 7948595 193.29 µM 0.0265862819018154 0.464016224167993 no 1519 0.489394857424912 2370 2971371 SGTC_37 0566-0070 1.56 µM 0.0262008601779519 0.4641887971307 no 1520 0.489548564898175 2359 1626686 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.0257655510355722 0.464383715335392 no 1521 0.489722169506276 2345 23847180 SGTC_271 rotenone 740 µM 0.0251097246675043 0.46467739057744 no 1522 0.489983721732977 2308 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1315 1237-0019 3.69 µM 0.0246424589321488 0.464886641210943 no 1523 0.490170076120471 2359 825140 SGTC_2464 5717415 7.67 µM 0.0240972084474629 0.465130827196488 no 1524 0.490387535006743 2367 5285744 SGTC_2580 diallyl disulphide 81.36 µM 0.0237636327744523 0.465280222822791 no 1525 0.49052057434686 2346 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1309 pyrazolanthrone 13.4 µM 0.0231760624249817 0.465543384717719 no 1526 0.490754916447947 2371 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1468 k284-1086 134 µM 0.0228955706327014 0.465669017125874 no 1527 0.490866786796953 2351 15996457 SGTC_3344 9148862 3.898 µM 0.0228914312758847 0.465670871171426 no 1528 0.490868437728707 2344 4905352 SGTC_2280 7785178 200 µM 0.0227348096182751 0.465741023604572 no 1529 0.490930904472727 2356 2954328 SGTC_1370 2001-0092 44.6 µM 0.0223132160453958 0.46592986493678 no 1530 0.491099053313866 2343 790957 SGTC_1781 st038725 66.3 µM 0.0218652389452064 0.466130532455541 no 1531 0.491277726722559 2345 4270275 YIL048W NEO1 SGTC_3217 9129673 49.47 µM 0.0215957880866505 0.46625123481858 no 1532 0.491385196684731 2359 17248312 SGTC_60 0986-0278 202 µM 0.0215779451526429 0.466259227793146 no 1533 0.491392313327167 2326 3110598 SGTC_2506 ethyl hematommate 54.16 µM 0.020866819888886 0.46657779665809 no 1534 0.491675947375473 2287 3940691 An allergen. SGTC_1353 1498-1206 8.11 µM 0.0204691516859527 0.466755952831751 no 1535 0.491834560153567 2358 6756808 SGTC_1417 3966-0327 90.4 µM 0.0202553197201919 0.466851752748675 no 1536 0.49191984908234 2358 651118 SGTC_1594 piperine 70.1 µM 0.0201666413240103 0.466891482559338 no 1537 0.491955219419082 2378 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2296 7971656 126.45 µM 0.0200180498422172 0.466958055448003 no 1538 0.492014486879208 2336 666570 SGTC_328 k915-0120 63.5 µM 0.0185508429745347 0.467615452011532 no 1539 0.492599708851159 2363 6624543 SGTC_626 0214-0009 33 µM 0.018368016117281 0.46769737562116 no 1540 0.492672633788745 2358 3437874 SGTC_1379 2144-0755 36.5 µM 0.0168186793945408 0.468391678620992 no 1541 0.49329063400129 2374 5392327 SGTC_1068 loratadine 26.9 µM 0.0158066684565858 0.468845242302151 no 1542 0.493694314221546 2342 3957 A H1 histamine antagonist. SGTC_617 3770-0098 35 µM 0.0154110774845092 0.469022549531295 no 1543 0.493852112961053 2360 5962639 SGTC_2836 9010338 19.48 µM 0.0153190178171847 0.469063812337586 no 1544 0.49388883511963 2377 2994051 SGTC_1423 4048-0112 5.59 µM 0.0144856827749523 0.469437343224709 no 1545 0.494221250778608 2384 X1423 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.0142833173656733 0.469528054787564 no 1546 0.494301974544458 2373 676296 Flavone; oxidizing agent. SGTC_830 4076-0286 57.8 µM 0.0140273790787287 0.46964278299308 no 1547 0.49440406891898 2363 6866659 SGTC_2085 5307070 144.047 µM 0.0127709097647309 0.470206050733463 no 1548 0.494905282624154 2378 2840351 SGTC_635 k038-0028 24.7 µM 0.0118062974936404 0.470638521207932 no 1549 0.495290078173326 2370 4035102 SGTC_3091 9116372 49.47 µM 0.0111045856621235 0.470953145721615 no 1550 0.495570002318408 2333 17169793 SGTC_84 0443-0269 128.823 µM 0.0110503855781533 0.470977448014038 no 1551 0.495591623696875 2385 6150058 SGTC_3259 9138485 49.47 µM 0.010044356771246 0.471428551826804 no 1552 0.495992948782594 2387 17646153 SGTC_2213 7173844 200 µM 0.00991946484897873 0.471484555996062 no 1553 0.496042770968668 2384 892728 SGTC_2850 9015429 58.44 µM 0.00987172966236205 0.471505961608468 no 1554 0.496061813620492 2379 6457570 SGTC_467 ro 31-8220 72.8 µM 0.00945753746344452 0.47169169885899 no 1555 0.496227044682776 2381 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_335 4077-0256 27.6 µM 0.00836987065606274 0.472179473232622 no 1556 0.496660943699968 2389 3121989 SGTC_3169 9102970 49.47 µM 0.00809989885673188 0.47230055110873 no 1557 0.496768643213117 2386 17027839 SGTC_1723 st034307 2.5525 µM 0.00776899938380611 0.472448957526564 no 1558 0.496900648847523 2389 867466 SGTC_3030 9087619 49.47 µM 0.00640463514319239 0.473060906831945 no 1559 0.49744493771868 2397 25236973 SGTC_2663 amphotericin b 100 µM 0.00638794436202582 0.473068393434703 no 1560 0.497451596240771 2391 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2883 9059145 45.46 µM 0.00609828946167829 0.473198318835107 no 1561 0.497567149574886 2391 16476510 SGTC_2109 5483026 200 µM 0.0053032876588069 0.4735549334124 no 1562 0.49788430424505 2398 759335 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.0052347222855278 0.473585690832097 no 1563 0.497911657491718 2398 390807 SGTC_1841 st054148 70 µM 0.00446501596276218 0.473930980549944 no 1564 0.49821872226849 2393 675442 SGTC_3103 9120822 49.47 µM 0.00424112542857547 0.474031421375465 no 1565 0.49830804082231 2399 17141819 SGTC_2325 6158266 200 µM 0.00397060091384971 0.474152785142044 no 1566 0.498415963579099 2391 3623240 SGTC_1554 st069299 38.7 µM 0.0037398303800726 0.474256316218488 no 1567 0.498508027017732 2386 24207999 SGTC_1945 st075991 56.6 µM 0.00361168889874131 0.474313805355578 no 1568 0.49855914772712 2386 1084980 SGTC_2385 9074692 200 µM 0.000960896775421797 0.475503169635882 no 1569 0.499616657708174 2399 17046906 SGTC_2913 7966556 36.57 µM 0.000255065686612215 0.475819900999872 no 1570 0.499898243514434 2404 2976516 SGTC_615 k087-0205 167 µM 0 0.47593436176008 no 1571 0.5 2401 9642773 SGTC_1363 1636-0063 10.4 µM 0 0.47593436176008 no 1572 0.5 2405 6072185 SGTC_187 1488-2104 32.728 µM -5.41052971900794e-05 0.475958641774889 no 1573 0.499978415109368 2406 2852859 SGTC_2472 5377652 49.4 µM -5.93642851714076e-05 0.475961001776041 no 1574 0.499976317076713 2406 1610903 SGTC_1269 0831-0796 3.05 µM -0.000267963743811325 0.476054612664021 no 1575 0.499893097934258 2407 927758 SGTC_1701 st028638 40.4 µM -0.000693940732760319 0.476245777778286 no 1576 0.499723157723828 2408 3490878 SGTC_2363 9053361 176 µM -0.00193127112198082 0.476801083702154 no 1577 0.499229534773471 2406 6469797 YMR079W SEC14 SGTC_1121 fusaric acid 630.51 nM -0.00482460544717552 0.478099767523037 no 1578 0.498075268367807 2421 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2892 9047358 58.44 µM -0.00518246738312099 0.478260411619835 no 1579 0.497932503898867 2420 6466771 SGTC_698 k064-0052 127 µM -0.00530810764555963 0.478316812328373 no 1580 0.497882381375608 2418 5088751 SGTC_374 0880-0231 82.3 µM -0.00638455070122971 0.478800052106409 no 1581 0.49745295008794 2414 6833587 SGTC_2183 6420625 130.508 µM -0.00690373501028413 0.47903313693962 no 1582 0.497245830089732 2417 2897619 SGTC_2350 9023895 38.85 µM -0.00765157813100849 0.479368889424262 no 1583 0.496947491757462 2426 2997209 SGTC_1026 k007-1105 30.6 µM -0.00773161558575798 0.479404824000988 no 1584 0.496915562377251 2412 7066794 SGTC_56 0957-0365 83.25 µM -0.00832063657200351 0.479669283065572 no 1585 0.496680584573795 2417 6752360 SGTC_1562 morin hydrate 59.1 µM -0.00832981343674154 0.479673403371987 no 1586 0.496676923661319 2443 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.00870860195534674 0.479843476937533 no 1587 0.496525814390441 2419 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_3136 9095672 49.47 µM -0.0093824859707153 0.480146055501148 no 1588 0.496256984568014 2418 17217380 SGTC_524 r073-0010 27.8 µM -0.00962850707952112 0.480256523533115 no 1589 0.496158840780053 2426 2772106 SGTC_350 k064-0020 19.8 µM -0.0118847853821097 0.481269703902185 no 1590 0.495258768232857 2433 2790705 SGTC_1966 st070145 16.1 µM -0.0128462923352481 0.481701505150761 no 1591 0.494875211796391 2427 3748532 SGTC_739 1486-1183 203 µM -0.0130308230195729 0.481784378140422 no 1592 0.494801600866211 2425 4346692 SGTC_932 2857-0803 154 µM -0.0131877288880884 0.481854845405835 no 1593 0.494739009859742 2470 674898 SGTC_2539 epi(13)torulosol 80 µM -0.0137057343947406 0.482087488464831 no 1594 0.494532374246179 2443 6708597 SGTC_574 1315-0397 40 µM -0.0142936462126746 0.482351534749758 no 1595 0.494297854351294 2433 6794277 SGTC_1981 st071826 47 µM -0.0148963655876672 0.482622239524015 no 1596 0.494057429721324 2468 11838600 SGTC_813 k007-0158 173 µM -0.0159324705472577 0.48308761331852 no 1597 0.493644132767975 2457 6523916 SGTC_1775 st081588 35.1725 µM -0.0166671119200732 0.483417596631511 no 1598 0.493351092200578 2439 1426443 YGL099W LSG1 SGTC_114 0364-0001 490.298 µM -0.0172944205165094 0.483699377630834 no 1599 0.493100868360878 2443 4003655 SGTC_2835 9006588 71.43 µM -0.0172984385951409 0.483701182539573 no 1600 0.493099265619187 2493 2345538 SGTC_1756 st041558 35.5 µM -0.0175397083847656 0.483809560808357 no 1601 0.493003027500946 2436 3955792 SGTC_2434 5670830 169.91 µM -0.0178811186129271 0.483962924154112 no 1602 0.492866845885584 2461 1549830 SGTC_2017 5132927 60.65 µM -0.0180170614474857 0.484023991082207 no 1603 0.492812621276673 2451 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_108 0509-0257 621.132 µM -0.0182076746050231 0.484109617115914 no 1604 0.492736590101382 2443 536624 SGTC_2298 7976326 193.81 µM -0.0203454237922223 0.485069972522544 no 1605 0.491883910164451 2461 2235818 SGTC_399 oxolinic acid 75 µM -0.0207419637447563 0.485248122513884 no 1606 0.491725746991932 2461 4628 A DNA gyrase inhibitor. SGTC_1267 0828-0272 9.49 µM -0.0210163861224012 0.485371411550301 no 1607 0.491616292163611 2447 745334 SGTC_2469 5655019 90.81 µM -0.0211559167356509 0.485434098647364 no 1608 0.491560639876217 2449 2788239 SGTC_1622 st003707 19.4 µM -0.021213264618547 0.485459863508522 no 1609 0.49153776651425 2502 10140899 SGTC_2999 9069765 71.4286 µM -0.0222565397443756 0.485928589448003 no 1610 0.49112165827295 2453 2097066 SGTC_3040 9091894 49.47 µM -0.0224608301985676 0.486020376004231 no 1611 0.491040178542276 2463 25236966 SGTC_1401 3807-4679 7.6 µM -0.0228125953781813 0.486178423860958 no 1612 0.490899880490501 2449 3291456 SGTC_2933 9026794 32.47 µM -0.0231555315121987 0.486332506923671 no 1613 0.490763104899633 2466 17586027 SGTC_2716 st080858 38.6235 µM -0.0242394586116305 0.486819534549104 no 1614 0.490330801973449 2452 5296050 SGTC_2249 haloperidol 116.36 µM -0.0248261092895544 0.487083135324671 no 1615 0.490096832636247 2448 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_422 cantharidin 155 µM -0.0251586262385033 0.487232548260416 no 1616 0.489964218989905 2443 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_312 4092-0653 6.84 µM -0.0264049410252786 0.48779258226005 no 1617 0.48946717657852 2523 1148278 SGTC_1729 st035615 45.989 µM -0.0266548741733825 0.487904893144685 no 1618 0.489367502761909 2548 17385451 SGTC_195 4234-0266 16.654 µM -0.0267420217538675 0.487944054330045 no 1619 0.489332748296253 2462 2303354 SGTC_552 k242-0005 476 µM -0.0276500653035353 0.488352105340776 no 1620 0.488970625286623 2495 4088318 SGTC_424 splitomicin 100 mM -0.0276564451190537 0.488354972306566 no 1621 0.488968081081437 2504 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_628 1636-0253 16 µM -0.0279468052295343 0.488485455162957 no 1622 0.48885228891552 2469 4456143 SGTC_2262 9014885 67.46 µM -0.0281644551549008 0.488583264117472 no 1623 0.488765493324062 2496 6457424 SGTC_745 0469-0705 296 µM -0.0289765690938267 0.488948223232526 no 1624 0.488441638950173 2467 3486736 SGTC_2519 cryptotanshinone 88.04 µM -0.0294926072293485 0.489180132491643 no 1625 0.488235857477402 2458 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2685 mycophenolic acid 18.85 µM -0.0298631413647369 0.489346654028731 no 1626 0.48808810082991 2483 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2808 7946468 45.46 µM -0.0300870377365677 0.489447276073022 no 1627 0.487998819219986 2484 2970879 SGTC_1487 3970-0795 2.82 µM -0.0315498475717152 0.490104698747997 no 1628 0.487415519648409 2488 3765103 SGTC_905 2-aminofluorene 215 µM -0.0317852238475632 0.490210485186146 no 1629 0.487321665172361 2462 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2195 6536160 144.242 µM -0.03193918119711 0.490279679446985 no 1630 0.487260276245237 2462 3834386 SGTC_68 0986-0284 82.829 µM -0.0322407908874504 0.49041523510502 no 1631 0.487140013325386 2624 423278 YIL048W NEO1 SGTC_575 k072-0246 11.9 µM -0.0325913619724976 0.490572797394706 no 1632 0.487000229160028 2468 6796779 SGTC_281 1672-3440 14.9 µM -0.0330145104512993 0.490762981161036 no 1633 0.486831508141288 2474 6833000 SGTC_922 1866-0035 480 µM -0.0334847331562164 0.490974324864517 no 1634 0.486644020090989 2475 3156169 SGTC_353 1988-1175 58.3 µM -0.0338820096325994 0.491152884535608 no 1635 0.486485619592272 2423 2788357 SGTC_327 1273-0057 3.96 µM -0.0349565645862889 0.491635862207589 no 1636 0.486057188063109 2466 3108138 SGTC_1140 3229-1848 2.98 µM -0.035817708149721 0.492022927252435 no 1637 0.48571385653243 2463 2849525 SGTC_1728 st035614 33.7865 µM -0.0362463095968241 0.492215576975205 no 1638 0.485542980255876 2591 15945546 SGTC_2407 paclitaxel 400 µM -0.0364895200753415 0.492324897134794 no 1639 0.485446017457127 2704 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_390 dec-rvkr-cmk 16.7 µM -0.0369565150945371 0.492534807339648 no 1640 0.485259838981544 2490 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2152 5568786 200 µM -0.0380272052286293 0.493016080963642 no 1641 0.484832995537685 2473 5399883 SGTC_184 1494-0393 24.714 µM -0.0382659025174974 0.493123376450824 no 1642 0.484737838356798 2462 3090647 SGTC_2207 7258803 200 µM -0.0384283724097772 0.493196407671097 no 1643 0.484673069886171 2474 3666799 SGTC_367 0335-0881 7.1 µM -0.0392650915712062 0.493572521660931 no 1644 0.484339519016121 2485 23828853 SGTC_480 am 92016 50 µM -0.0394193651038244 0.4936418698567 no 1645 0.484278020393815 2525 2129 K+ channel blocker. SGTC_322 k048-0136 19.3 µM -0.0411999269094039 0.494442271648802 no 1646 0.483568255971281 2543 6823282 SGTC_2871 9038510 12.99 µM -0.041428559438233 0.494545048700539 no 1647 0.483477122598511 2485 4945164 SGTC_851 0394-0702 453 µM -0.0414724060678472 0.49456475909281 no 1648 0.483459645344764 2470 762646 SGTC_928 2764-0428 58.7 µM -0.0417977313753213 0.494711003114622 no 1649 0.483329971767229 2587 662578 SGTC_2721 ifenprodil 61.44 µM -0.0422953360602577 0.494934693537431 no 1650 0.4831316316229 2491 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2442 5158906 48.48 µM -0.0424138005636365 0.494987947644071 no 1651 0.483084413495326 2535 1893835 SGTC_3080 9117754 49.47 µM -0.0426799761306859 0.495107603575212 no 1652 0.482978320877832 2478 9550191 SGTC_983 1491-0821 12.2 µM -0.0427493840062164 0.495138805099236 no 1653 0.482950656390746 2511 46495113 SGTC_316 k060-0003 58.6 µM -0.0427671741729803 0.49514680247193 no 1654 0.48294356562593 2559 6152314 SGTC_1965 Pectolinarigenin 58.4 µM -0.0433530442203162 0.495410174942177 no 1655 0.482710053882531 2486 5320438 An anti-inflammatory. SGTC_2129 girgensonine 121.053 µM -0.0440809562418057 0.495737403844404 no 1656 0.482419936372474 2530 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3150 9097574 49.47 µM -0.0443930539012235 0.495877706546201 no 1657 0.48229554918801 2496 17217476 SGTC_692 k241-0027 77.8 µM -0.0449148984186881 0.496112301540103 no 1658 0.482087570804072 2518 3600480 SGTC_18 0111-0177 500 nM -0.0452584237424423 0.496266733950725 no 1659 0.481950663252767 2483 721752 SGTC_1790 st045711 43.5 µM -0.0457766773137233 0.49649971680213 no 1660 0.481744124063226 2495 585119 SGTC_1207 2099-0101 141 µM -0.0458666227331491 0.496540152229139 no 1661 0.481708278683163 2503 5837381 SGTC_2115 tiliquinol 12.7705 µM -0.0459953340422927 0.496598015123448 no 1662 0.481656984435139 2554 71208 A bioactive hydroxyquinoline. SGTC_1292 0kpi-0043 232 µM -0.0460412694540559 0.496618665664043 no 1663 0.481638678250844 2507 3333905 SGTC_645 0845-0943 5.41 µM -0.0461286883047686 0.496657965359065 no 1664 0.481603840189829 2512 1885106 SGTC_1105 epirubicin 18.1 µM -0.0467582798247267 0.496941003127536 no 1665 0.481352940258472 2478 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_225 nsc-122657 1.016 µM -0.0470931142368709 0.497091531180105 no 1666 0.481219507646771 2587 275685 SGTC_1024 4507-0395 26 µM -0.0470991752151173 0.497094255955452 no 1667 0.481217092346398 2636 4201836 SGTC_156 3474-0145 5.642 µM -0.0478043790979514 0.49741128853383 no 1668 0.480936073266491 2473 2265471 SGTC_2980 9014342 25.29 µM -0.0481110186169423 0.497549142405107 no 1669 0.480813882394718 2620 2996599 SGTC_2805 7950783 58.44 µM -0.048662163885231 0.497796917810392 no 1670 0.48059426448942 2534 1178958 YDL195W SEC31 SGTC_2870 9038528 12.99 µM -0.0493351013238999 0.498099447807486 no 1671 0.480326123376842 2626 6463316 SGTC_1279 0874-0590 65.2 µM -0.0494591158398751 0.498155200679501 no 1672 0.480276709067153 2552 3523074 SGTC_2954 9074818 52.69 µM -0.0495713573541845 0.498205660825951 no 1673 0.480231986040155 2541 16648742 SGTC_1436 4092-1007 8.32 µM -0.0495895906655481 0.498213857934426 no 1674 0.480224720936454 2499 2881121 SGTC_2753 fluvastatin 17.09 µM -0.0499809459094267 0.498389798800767 no 1675 0.480068786151671 2555 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1510 1123-0200 71.5 µM -0.0499911842022503 0.498394401615833 no 1676 0.480064706763363 2519 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_702 1488-0190 94 µM -0.0510335619449876 0.498863022938842 no 1677 0.479649388408887 2493 949357 SGTC_1354 1498-1681 81 µM -0.0534087721983776 0.499930850043429 no 1678 0.478703107993307 2553 5754243 SGTC_741 4582-0002 126 µM -0.0537163977480475 0.499930850043429 no 1679 0.478580559075031 2513 2912688 SGTC_1523 st012844 44.7 µM -0.0542599871301743 0.499686467367909 no 1680 0.478364014104569 2610 4274103 SGTC_1304 1165-0502 251 µM -0.0553439654237678 0.499199141301458 no 1681 0.47793221823729 2532 767425 SGTC_275 trichlorophene 5.69 µM -0.056035681075448 0.498888166033526 no 1682 0.4776566912085 2585 62616 SGTC_310 1273-0058 1.06 µM -0.0560629071501602 0.498875925993627 no 1683 0.477645846623812 2506 2734232 SGTC_2495 cafestol 54.53 µM -0.0566902974933428 0.498593870122739 no 1684 0.47739595153285 2683 16667697 An anti-infammatory. SGTC_113 0099-0221 2.5 µM -0.0574538470598113 0.498250602113075 no 1685 0.477091835025916 2507 89219 SGTC_887 0885-0007 9.62 µM -0.0584947672618046 0.497782639074768 no 1686 0.476677265239957 2641 5719458 SGTC_2421 5690543 90.72 µM -0.059334427294419 0.497405158095372 no 1687 0.47634287019631 2561 3397993 SGTC_2083 5306046 65.942 µM -0.05988815277617 0.497156224265864 no 1688 0.47612235783697 2523 539837 SGTC_2082 5219693 150 µM -0.0602320848680491 0.49700160608362 no 1689 0.475985396033042 2503 2834649 SGTC_3032 9089427 49.47 µM -0.0603642067463738 0.496942209463197 no 1690 0.475932782764052 2580 17173707 SGTC_2075 5212009 200 µM -0.0606959571602968 0.49679306827781 no 1691 0.475800675732684 2533 780898 SGTC_3035 9091303 49.47 µM -0.0619496182633893 0.496229478619275 no 1692 0.47530147684375 2517 25237002 SGTC_1051 3253-3903 78 µM -0.06264696210911 0.495915987368895 no 1693 0.475023816239546 2497 5509239 SGTC_625 k213-0058 121 µM -0.0631264893167501 0.495700417141239 no 1694 0.474832890468066 2563 3655420 SGTC_218 alverine citrate 93.75 µM -0.0636054710418164 0.495485093387205 no 1695 0.474642187652289 2596 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_647 0140-0236 81 µM -0.0636084913183323 0.495483735641645 no 1696 0.474640985171279 2553 990837 SGTC_2995 9067767 71.4286 µM -0.0637701212523904 0.495411076038329 no 1697 0.474576634802408 2575 11673567 SGTC_2277 7947813 106.88 µM -0.0637870598368835 0.495403461425235 no 1698 0.474569891014722 2738 1246798 SGTC_1583 clindamycin 39.6 µM -0.0642091926221381 0.495213695358789 no 1699 0.474401828923646 2532 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2441 5730946 39.09 µM -0.0646173596415864 0.495030208508516 no 1700 0.474239331300179 2597 1774275 SGTC_1635 st007035 42.4 µM -0.0649554120036262 0.494878241700894 no 1701 0.47410475065323 2510 3716403 SGTC_2785 7756463 72.73 µM -0.0656597998414771 0.494561596212807 no 1702 0.473824339195892 2529 2201551 SGTC_1671 st016596 74.5 µM -0.065686896966808 0.494549415231386 no 1703 0.473813552293913 2547 2829167 SGTC_961 1252-1571 372 µM -0.0661129478504085 0.494357893085365 no 1704 0.473643951255919 2548 6813498 SGTC_255 tunicamycin 200.472 nM -0.0663041381998748 0.494271947935504 no 1705 0.47356784433502 2528 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1364 1653-0028 37.6 µM -0.0668092111068971 0.494044905512729 no 1706 0.473366795196197 2590 5718652 SGTC_2032 5185112 25.99 µM -0.0671810052037164 0.493877776350089 no 1707 0.473218803304465 2564 5718189 SGTC_153 4077-0274 519.67 µM -0.0672103585985395 0.493864581435311 no 1708 0.473207119401923 2532 3121976 SGTC_3045 9092950 49.47 µM -0.0673513272550388 0.493801213410342 no 1709 0.473151008188159 2524 44120432 SGTC_1621 st003705 32.4 µM -0.067373040365742 0.493791452978333 no 1710 0.473142365541235 2505 24207032 SGTC_3283 9109332 35.8195 µM -0.0684461438015201 0.493309078519936 no 1711 0.47271524524432 2503 17027281 SGTC_3199 9111318 49.47 µM -0.0684855387917846 0.493291370122691 no 1712 0.472699565709638 2583 8548020 SGTC_2694 st077685 81.9 µM -0.0690168554132921 0.493052539898502 no 1713 0.47248810140558 2534 2838096 SGTC_1411 3909-8223 150 µM -0.0691506752363993 0.492992387420211 no 1714 0.472434842263387 2531 X1411 SGTC_1392 3455-1037 33.9 µM -0.0698253366792906 0.492689127198001 no 1715 0.472166340319052 2631 981132 SGTC_459 nigericin 15.3 µM -0.0708594786061083 0.492224288812443 no 1716 0.471754796829101 2599 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_276 colchicine 750 µM -0.0714854951426921 0.491942904560839 no 1717 0.471505684111261 2639 2833 A microtubule depolymerizer. SGTC_129 0088-0017 176.636 µM -0.072503912900648 0.491485150971413 no 1718 0.471100445811191 2539 182446 SGTC_677 0929-0063 136 µM -0.0730942978225998 0.491219792649287 no 1719 0.470865539600336 2537 1539583 SGTC_115 0527-0192 112.043 µM -0.0738201489636083 0.490893552119867 no 1720 0.470576747106157 2574 4233931 SGTC_378 3970-0959 8.33 µM -0.0743453834267224 0.490657484403959 no 1721 0.470367783085632 2620 6615653 SGTC_2361 9034121 116 µM -0.0752075785433026 0.490269976158617 no 1722 0.470024777314209 2577 6496917 SGTC_2817 7995342 71.43 µM -0.076132665041932 0.489854211994698 no 1723 0.469656776300486 2545 18879975 SGTC_1787 fluconazole 80 µM -0.076531253811123 0.489675076522041 no 1724 0.469498224967557 2568 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2739 tacrine 100.86 µM -0.0766265439783474 0.489632251113865 no 1725 0.469460320994719 2617 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_910 3454-3003 490 µM -0.0776493693534502 0.489172579475151 no 1726 0.469053484918231 2533 820824 SGTC_2188 6126565 140.678 µM -0.0781079681002759 0.488966483592432 no 1727 0.468871084466839 2551 874518 SGTC_558 k064-0027 21.3 µM -0.0782029458749881 0.488923800614329 no 1728 0.468833309363548 2610 5088526 SGTC_1829 berberine 14.4 µM -0.0784021949017735 0.488834258585488 no 1729 0.468754063814151 2701 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2338 7999974 200 µM -0.0796240097651761 0.488285190428018 no 1730 0.468268149405199 2640 315925 SGTC_347 4534-1311 26.2 µM -0.0797833867281025 0.488213570049932 no 1731 0.468204768834526 2529 2862016 SGTC_2373 9071805 200 µM -0.0798452274594857 0.488185780335603 no 1732 0.468180176407869 2551 10149009 SGTC_149 3970-0822 46.1 µM -0.0798512887387419 0.488183056547826 no 1733 0.468177766003622 2545 3114250 YBL034C STU1 SGTC_1988 st071872 53.4 µM -0.0803609042888012 0.487954050009299 no 1734 0.46797511008055 2534 16414116 SGTC_718 1130-0073 349 µM -0.0810917289231396 0.487625645435518 no 1735 0.467684501694551 2625 6740020 SGTC_1385 3091-4834 14.1 µM -0.0818948862798591 0.487264746994986 no 1736 0.467365150469429 2628 4072814 SGTC_2069 5228469 200 µM -0.0832735129369069 0.486645286131045 no 1737 0.466817030371516 2641 2835210 SGTC_1911 st060208 74.3 µM -0.0839957136446102 0.486320791118431 no 1738 0.466529919871334 2643 688783 SGTC_2948 9070189 9.45 µM -0.084461791589992 0.486111380487665 no 1739 0.466344640073855 2600 6473636 YDL196W YDL196W SGTC_700 3453-2283 142 µM -0.085210583124737 0.485774953586822 no 1740 0.466046988533612 2642 565664 SGTC_1991 st073000 8.92 µM -0.0854788220279836 0.485654438137961 no 1741 0.465940365707425 2733 4301969 YIL048W NEO1 SGTC_2438 5259590 200 µM -0.0855800474439313 0.485608959517559 no 1742 0.46590013004629 2631 1201127 SGTC_1150 3909-7983 10.9 µM -0.0856482814965862 0.48557830338379 no 1743 0.465873008178824 2580 23965914 SGTC_1318 1280-3875 124 µM -0.0861211056791916 0.485365875712021 no 1744 0.465685073024471 2606 373245 SGTC_3117 9124945 49.47 µM -0.0868234299909345 0.485050347253809 no 1745 0.465405931753921 2537 17592065 SGTC_3164 9100705 49.47 µM -0.0875968109096687 0.484702906514154 no 1746 0.465098568481308 2677 17174235 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.0877064267867008 0.484653662605412 no 1747 0.465055005737266 2600 688788 SGTC_2040 5100729 123 µM -0.0889691591773371 0.484086408942644 no 1748 0.464553210153031 2562 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_308 4092-1169 104 µM -0.0891649415019361 0.483998461063455 no 1749 0.464475413496991 2577 2268590 YDL196W YDL196W SGTC_787 4152-0075 138 µM -0.0909641553854411 0.483190268585998 no 1750 0.463760536397806 2609 9566539 SGTC_1432 4049-0298 68.4 µM -0.0913485623557523 0.483017604892693 no 1751 0.46360781603887 2611 741646 SGTC_1711 st032263 62.8 µM -0.092040163716779 0.482706967044385 no 1752 0.463333064487245 2612 3958979 SGTC_1209 2323-2347 50.3 µM -0.0921202798155266 0.482670982983063 no 1753 0.463301237999218 2552 5412760 SGTC_2381 9035592 200 µM -0.0921920996579656 0.482638725296504 no 1754 0.463272707436753 2602 4749657 SGTC_1031 k035-0009 16 µM -0.0924996894059286 0.482500573487531 no 1755 0.463150518991196 2715 5180959 SGTC_1493 4348-0038 111 µM -0.0925624106711479 0.482472402922215 no 1756 0.463125603717487 2573 800424 SGTC_2630 antimycin a 100 µM -0.0934606182509422 0.482068992550857 no 1757 0.462768817396458 2546 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1196 1588-0294 184 µM -0.0935749040590798 0.482017664877264 no 1758 0.462723422890651 2642 6144269 SGTC_3208 9114115 49.47 µM -0.0938842746381062 0.481878722858444 no 1759 0.462600542839203 2642 650895 SGTC_818 4072-2707 53.5 µM -0.0941136668028313 0.481775701520015 no 1760 0.46250943201536 2579 882871 SGTC_2926 9010726 65.15 µM -0.0955051985992111 0.481150782930962 no 1761 0.46195678062602 2658 2994293 SGTC_3050 9093513 49.47 µM -0.0958165714356858 0.481010955781213 no 1762 0.461833127906725 2586 25236664 SGTC_1184 1269-1718 139 µM -0.0966994409528935 0.480614501304422 no 1763 0.461482541903167 2677 5403821 SGTC_1404 3909-7820 48.3 µM -0.0980843438012344 0.479992646445957 no 1764 0.460932659706258 2588 23741373 SGTC_167 3672-0051 66.205 µM -0.0987140820730725 0.479709894751293 no 1765 0.460682643800363 2586 3237971 SGTC_573 3702-0553 84.7 µM -0.0989742542870515 0.479593080725576 no 1766 0.460579355908863 2591 1222756 SGTC_357 1325-0123 420 µM -0.099652195127406 0.479288702141786 no 1767 0.460310227151349 2584 1098503 SGTC_344 k064-0035 6.43 µM -0.100496682141562 0.47890956537912 no 1768 0.45997500838589 2595 5088750 SGTC_3075 9116269 49.47 µM -0.104976708552251 0.476898561978723 no 1769 0.458197145233957 2710 17015205 YNL244C SUI1 SGTC_1003 4049-0218 100 µM -0.105153823500554 0.476819070008911 no 1770 0.458126875508539 2704 295161 SGTC_809 3998-0021 90 µM -0.105988959643649 0.476444260276449 no 1771 0.457795555886193 2583 715485 SGTC_1514 1189-1591 158 µM -0.106700356693528 0.476125001166277 no 1772 0.457513349811504 2767 767698 YMR146C TIF34 SGTC_2455 5377712 9.75 µM -0.107182031386232 0.475908845009194 no 1773 0.457322285090793 2666 2243908 SGTC_2035 5154463 94.595 µM -0.10759459595355 0.475723708320706 no 1774 0.457158641955073 2672 2769623 SGTC_1134 3477-0009 42.5 µM -0.107818613170206 0.475623183689624 no 1775 0.457069788893003 2794 3973534 SGTC_261 5-fluorouridine 15.376 µM -0.108611026043824 0.475267611854693 no 1776 0.456755507488139 2642 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_712 r015-0009 80.6 µM -0.108612075406702 0.475267140997141 no 1777 0.45675509131486 2687 6813872 YLR060W FRS1 SGTC_1444 4112-3581 28 µM -0.109148350148624 0.475026514747421 no 1778 0.456542413032476 2596 2877249 SGTC_2310 7668677 200 µM -0.111252438765972 0.474082499879958 no 1779 0.455708084780369 2724 2197143 SGTC_2156 5649887 115 µM -0.11129772718931 0.474062182475722 no 1780 0.455690128824933 2716 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1887 st057648 70.8 µM -0.111596389054458 0.473928197744684 no 1781 0.455571717627913 2766 688672 SGTC_2311 7694451 200 µM -0.112177346600534 0.473667578889209 no 1782 0.455341395289058 2676 2163142 SGTC_1891 st059073 26.2 µM -0.11266081242638 0.473450703624773 no 1783 0.455149735270819 2653 688754 SGTC_643 k048-0106 28.4 µM -0.114903028024062 0.472444984405891 no 1784 0.454260992488916 2726 6763920 SGTC_769 0302-0231 76 µM -0.11526079504243 0.47228452833553 no 1785 0.454119206113523 2664 571869 YER009W NTF2 SGTC_2287 7945887 168.79 µM -0.115703397886687 0.472086030202156 no 1786 0.453943806608967 2671 1245853 SGTC_1424 4048-1941 275 µM -0.116052301391372 0.471929559150291 no 1787 0.453805545634735 2710 X1424 SGTC_364 0083-0097 67.7 µM -0.116468615692796 0.471742862378189 no 1788 0.4536405789208 2742 5207356 SGTC_2746 daunorubicin 9.88 µM -0.117446370459515 0.471304411276057 no 1789 0.45325316999587 2594 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1453 4237-0541 195 µM -0.118413233546268 0.470870878488356 no 1790 0.452870120348206 2623 739892 SGTC_2708 st078559 56 µM -0.119611002460597 0.470333857512415 no 1791 0.45239565179945 2626 17250902 SGTC_1087 pterostilbene 9.05 µM -0.119769281960802 0.470262896743469 no 1792 0.452332958093468 2722 5281727 Similar to reservatol, lowers cholesterol. SGTC_1850 st056238 17 µM -0.120019917157757 0.470150532473907 no 1793 0.452233685196781 2591 5393177 SGTC_87 0100-0052 35.5 µM -0.120285419067595 0.470031505782014 no 1794 0.452128527072164 2642 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.120868942164563 0.46976991699838 no 1795 0.451897421169395 2620 688662 SGTC_2193 5925765 200 µM -0.122012457195288 0.469257326205022 no 1796 0.451444576284583 2716 877370 SGTC_1274 0865-0114 173 µM -0.122335682552189 0.469112446760483 no 1797 0.451316586815191 2679 870624 SGTC_8 0354-0001 70 µM -0.122392799452275 0.469086845651784 no 1798 0.45129397042192 2622 4993152 SGTC_373 0844-0104 25.9 µM -0.122726232277635 0.468937395942581 no 1799 0.451161945267711 2692 5375804 SGTC_1761 st044296 37 µM -0.123304442256404 0.468678243744724 no 1800 0.450933011633584 2604 1826700 SGTC_1557 sumaresinolic acid 42.3 µM -0.123619505522169 0.468537038793103 no 1801 0.450808273888304 2610 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2930 9013230 14.89 µM -0.124711033402241 0.468047868905402 no 1802 0.450376161103801 2702 2995857 SGTC_31 0508-1974 57.237 µM -0.125340911225288 0.467765610100304 no 1803 0.450126832536866 2650 6810525 SGTC_1282 0886-0010 32.4 µM -0.125760120048504 0.467577764576507 no 1804 0.449960905330862 2691 2836211 YNL267W PIK1 SGTC_819 1013-0258 27.7 µM -0.126353474357915 0.46731189762176 no 1805 0.449726064492473 2646 5753198 SGTC_3100 9120536 49.47 µM -0.128003542568105 0.466572621109935 no 1806 0.449073084771107 2590 16421196 SGTC_545 4218-0007 221 µM -0.129068986821463 0.466095333518318 no 1807 0.448651530820867 2717 2840508 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.129118113056655 0.466073327585018 no 1808 0.448632094916267 2741 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2841 9004761 38.96 µM -0.129981634552562 0.465686533005967 no 1809 0.448290478457365 2657 2991039 SGTC_1715 st032160 10.2275 µM -0.131741302887652 0.464898430788346 no 1810 0.447594457617451 2701 5289825 SGTC_274 sirtinol 40.1 µM -0.1317654903438 0.464887598910543 no 1811 0.44758489160788 2682 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_679 0422-0091 41.4 µM -0.131776771411765 0.464882546914429 no 1812 0.447580430016247 2619 627384 YHR062C RPP1 SGTC_1673 st016611 27.3 µM -0.132221406581866 0.464683430642426 no 1813 0.447404584883097 2840 5226799 SGTC_612 0302-0167 22.4 µM -0.132887547414727 0.464385136393813 no 1814 0.447141157639919 2713 235821 SGTC_1530 rhein 70.4 µM -0.1332885347187 0.464205586096257 no 1815 0.446982597331965 2630 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1141 3253-0389 52.6 µM -0.134344532153199 0.463732776535155 no 1816 0.446565070410959 2617 5402031 SGTC_1615 st002656 86.5 µM -0.135025362018714 0.463427970645255 no 1817 0.446295910982496 2623 1584458 SGTC_758 0868-0029 16 µM -0.135341265550628 0.463286548675994 no 1818 0.446171030007108 2767 762687 SGTC_3250 9135583 49.47 µM -0.136722445881977 0.462668284124633 no 1819 0.445625093445727 2784 7699353 SGTC_321 4534-3890 65.3 µM -0.137466270336136 0.462335359585863 no 1820 0.445331125988666 2758 699746 SGTC_3308 9128332 17.569 µM -0.137627767030427 0.462263079594298 no 1821 0.445267304716888 2788 17332805 YDL196W YDL196W SGTC_1546 5-methoxyflavanone 78.7 µM -0.137707274126193 0.462227495594686 no 1822 0.445235885127445 2715 147795 SGTC_2364 9055074 200 µM -0.139179826208988 0.461568498768027 no 1823 0.44465402484458 2727 6470630 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.140903631101058 0.460797195398721 no 1824 0.443973036782716 2774 1609 A potent and irreversible inhibitor of serine proteases. SGTC_3052 9092717 49.47 µM -0.141389033734418 0.460580032170379 no 1825 0.443781308527513 2814 25237534 SGTC_1078 idebenone 36.1 µM -0.14205492315363 0.460282140490907 no 1826 0.443518311558185 2728 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2286 7945697 125 µM -0.142954036658678 0.459879949298311 no 1827 0.443163240847771 2739 1245733 SGTC_599 1935-0052 86.5 µM -0.143553427314092 0.459611852822627 no 1828 0.442926559620979 2660 9557311 SGTC_2761 levamisole 97.89 µM -0.143826399986586 0.459489763218323 no 1829 0.442818777719182 2739 26879 An alkaline phosphatase inhibitor. SGTC_1660 st012960 28.1 µM -0.144296580720537 0.459279479410499 no 1830 0.442633139121128 2734 24207266 SGTC_942 3253-1115 227 µM -0.144913944163199 0.459003386861674 no 1831 0.442389408401243 2810 46497897 SGTC_1935 st074532 41.6 µM -0.145832095802108 0.458592814730431 no 1832 0.442026968983841 2798 2829742 SGTC_2132 5317594 122.667 µM -0.146959435052355 0.458088760114911 no 1833 0.441582019371848 2677 794577 SGTC_2824 7998404 51.95 µM -0.147016192052414 0.45806338476616 no 1834 0.44155961989159 2665 837851 SGTC_759 3486-0358 89.3 µM -0.147523770786966 0.457836460238931 no 1835 0.441359309309309 2672 875103 SGTC_221 trifluoperazine 10.304 µM -0.148267132167878 0.457504148582211 no 1836 0.441065976679849 2676 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2439 5492030 7.2 µM -0.149029168748744 0.45716351921862 no 1837 0.440765308318517 2765 5722370 SGTC_2803 7707263 71.43 µM -0.151843634497011 0.455905731344791 no 1838 0.439655132891876 2703 2199229 SGTC_2120 5538279 151.968 µM -0.151948198527737 0.455859009996752 no 1839 0.439613896345975 2699 2058197 SGTC_3179 9107801 49.47 µM -0.152584260416931 0.455574817705351 no 1840 0.439363069005301 2709 4818259 SGTC_903 1134-0042 114 µM -0.15302241292609 0.455379064488063 no 1841 0.439190300241787 2682 701009 SGTC_2078 5212016 200 µM -0.153034668440522 0.455373589252416 no 1842 0.439185467912559 2653 1899708 SGTC_3248 9135562 49.47 µM -0.155500735423908 0.454272030667496 no 1843 0.438213287104558 2714 17650701 SGTC_1088 bifonazole 369 nM -0.156598126367312 0.453781953602628 no 1844 0.437780789634311 2648 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2290 7904846 200 µM -0.157678215966392 0.453299671745096 no 1845 0.437355183438496 2757 2962154 SGTC_3309 9129340 25.759 µM -0.158977869760397 0.452719441387755 no 1846 0.43684315472256 2740 17158987 SGTC_3353 9151644 39.2805 µM -0.159185277769388 0.452626853402882 no 1847 0.43676145129919 2799 4909158 SGTC_1950 st077106 7.18 µM -0.159220548935299 0.452611108432041 no 1848 0.436747557335438 2780 13831864 SGTC_2101 5377231 179.231 µM -0.160893091977715 0.451864574878303 no 1849 0.436088801612505 2814 2844213 SGTC_663 1486-0733 13.9 µM -0.161678300406955 0.451514158466161 no 1850 0.43577959673185 2691 722445 YPR165W RHO1 SGTC_3298 9116858 71.43 µM -0.161882515829162 0.451423029052501 no 1851 0.435699185775271 2811 2506942 SGTC_1942 st076330 65.2 µM -0.162328539043001 0.451224003854454 no 1852 0.435523570905511 2854 24208414 SGTC_2689 tacrolimus 100 µM -0.16391861335953 0.450514578441037 no 1853 0.434897606976674 2789 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1365 1672-3266 55.4 µM -0.164519469071798 0.450246542496827 no 1854 0.434661110731374 2784 6415873 SGTC_1063 disulfiram 1.84 µM -0.165105756080201 0.44998502738373 no 1855 0.434430371247345 2673 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_529 4076-0302 30.3 µM -0.165155560081001 0.449962813156074 no 1856 0.434410771381575 2717 5816522 SGTC_1953 st076800 12.1 µM -0.165782698520401 0.449683102159576 no 1857 0.434163981141038 2723 297591 SGTC_1357 1503-1303 39.5 µM -0.166147655552108 0.449520338600535 no 1858 0.43402037579757 2721 292895 SGTC_592 k241-0073 46.5 µM -0.166217419136486 0.44948922639901 no 1859 0.433992925821159 2789 4230158 SGTC_3218 9131285 49.47 µM -0.166766164122867 0.449244515517837 no 1860 0.433777021462818 2783 17156417 SGTC_2688 kanamycin b 96.69 µM -0.166966955863175 0.449154977972332 no 1861 0.433698024651089 2810 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_3119 9125183 49.47 µM -0.167652660025731 0.448849226635521 no 1862 0.433428270377544 2776 22695334 SGTC_882 0843-0131 351 µM -0.167728839445597 0.448815260564594 no 1863 0.433398303499141 2698 5425421 SGTC_306 1672-3436 11.6 µM -0.167844394617984 0.448763738767384 no 1864 0.433352848018899 2803 6797378 SGTC_1303 1160-0052 261 µM -0.168024485117723 0.448683444766499 no 1865 0.433282008290543 2719 3562476 SGTC_527 4476-4215 268 µM -0.168329932436897 0.448547264781537 no 1866 0.433161863572644 2726 4418754 SGTC_403 arphamenine a 50 µM -0.16843901383446 0.448498633630834 no 1867 0.43311895896729 2695 5487158 An arginine aminopeptidase inhibitor. SGTC_264 promethazine 12.5 mM -0.168486513521172 0.448477457352418 no 1868 0.433100276327657 2713 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2740 felodipine 17.08 µM -0.168877551011749 0.448303130865382 no 1869 0.432946478630218 2805 3333 L-type calcium channel blocker SGTC_3073 9114972 49.47 µM -0.169650034410514 0.447958783236948 no 1870 0.432642685540074 2793 41905075 SGTC_2318 6029776 164 µM -0.170119599032968 0.447749485957065 no 1871 0.432458040189265 2858 818325 SGTC_2260 7964312 200 µM -0.170540802779942 0.447561756763825 no 1872 0.432292424174115 2911 231951 SGTC_2458 5808907 16.39 µM -0.17062542809763 0.447524040940002 no 1873 0.43225915119425 2724 2731747 SGTC_3101 9120531 49.47 µM -0.170685151905234 0.447497423510368 no 1874 0.432235669278534 2926 24824904 SGTC_772 k072-0172 35.3 µM -0.171065358604104 0.447327980300633 no 1875 0.432086187076807 2732 5861980 SGTC_1177 0983-0204 23.6 µM -0.171432589036099 0.447164329230101 no 1876 0.431941815858565 2824 766818 SGTC_578 3460-0051 92 µM -0.171634306084962 0.447074440693853 no 1877 0.4318625176474 2704 2876744 SGTC_584 0986-0246 15.4 µM -0.171678253259165 0.447054857448609 no 1878 0.431845241671607 2693 53315 YDR232W HEM1 SGTC_83 0170-0301 39.027 µM -0.1723397053825 0.446760124216667 no 1879 0.431585235463089 2706 3089716 SGTC_146 3448-8650 53.125 µM -0.172391775574894 0.446736923759497 no 1880 0.431564768763511 2751 2891488 YIL048W NEO1 SGTC_2566 crystal violet carbinol 226 nM -0.173406534003927 0.446284823271694 no 1881 0.43116594475885 2889 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_3014 9081533 49.47 µM -0.174151487785976 0.445952971970035 no 1882 0.430873204990719 2832 21367265 SGTC_1473 k844-0725 134 µM -0.175398415238906 0.445397593482047 no 1883 0.430383292870338 2736 54682906 SGTC_1884 5633444 25 µM -0.175755319501631 0.445238648856384 no 1884 0.430243086499078 2875 5724239 SGTC_442 cape 100 µM -0.176092845640029 0.445088342230686 no 1885 0.430110500726633 2813 5281787 SGTC_488 nitrendipine 139 µM -0.176572418634061 0.444874793097092 no 1886 0.429922130188393 2702 4507 Dihydropyridine L-type calcium channel blocker. SGTC_431 k089-0097 107 µM -0.177115420531643 0.444633019011684 no 1887 0.4297088647918 2767 5499420 SGTC_16 erodoxin 22.806 µM -0.17716673349464 0.444610172743383 no 1888 0.42968871255285 2736 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1183 1254-0324 198 µM -0.179082685715229 0.443757258309657 no 1889 0.428936388514072 2842 5799357 SGTC_2634 4'-methoxyflavone 100 µM -0.181949697031363 0.442481453529284 no 1890 0.427811101393123 2786 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_687 k029-0044 34.9 µM -0.182107850685234 0.442411093227443 no 1891 0.42774904389888 2862 5829338 SGTC_2649 anisomycin 9.56 µM -0.182935278963851 0.442043011866224 no 1892 0.427424400674067 2770 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_449 xestospongin c 11.1929 µM -0.184075272682585 0.441535967829543 no 1893 0.426977202270124 2864 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1229 0139-0193 12.2 µM -0.184634460493947 0.441287288405086 no 1894 0.426757877524125 2839 3090752 SGTC_767 0929-0023 86 µM -0.185890400004539 0.440728837296201 no 1895 0.426265355339359 2755 1204563 SGTC_3271 9137798 49.47 µM -0.187035117866022 0.440219943312939 no 1896 0.425816549345106 2878 6498326 SGTC_45 0kpi-0036 14.9 µM -0.18727731263086 0.440112286213359 no 1897 0.425721605087643 2861 2795021 SGTC_782 0083-0095 30.5 µM -0.187416208913302 0.440050547937452 no 1898 0.42566715744542 2704 3591729 An indicator and reagent. SGTC_3063 1327-0034 4 µM -0.187529707832891 0.440000099666381 no 1899 0.425622666676437 2759 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1973 st070275 50.2 µM -0.188146273826424 0.439726063979813 no 1900 0.42538099375239 2695 17118334 SGTC_1380 2291-0730 164 µM -0.188675444080688 0.439490894766515 no 1901 0.425173599340573 2824 2999191 SGTC_2081 5214970 32.255 µM -0.190614656876321 0.438629269901247 no 1902 0.424413753107872 2808 2063512 SGTC_216 k038-0035 28.382 µM -0.191212657181201 0.438363626775818 no 1903 0.424179493788546 2743 4444231 YPR107C YTH1 SGTC_1616 st002734 56.1 µM -0.191389945825658 0.43828487711421 no 1904 0.424110048270265 2768 4026101 SGTC_1155 4088-0394 48.2 µM -0.19196044910591 0.438031482445002 no 1905 0.423886593129345 2725 2326248 SGTC_1289 0976-0073 69.1 µM -0.193536839782234 0.437331445351668 no 1906 0.423269278716148 2862 3391136 SGTC_1920 st075728 45.7 µM -0.194394239155103 0.436950777173423 no 1907 0.422933600186562 2933 3400306 SGTC_1362 1611-0397 101 µM -0.194933660153514 0.436711314925813 no 1908 0.422722441320978 2777 27816 SGTC_1843 st055809 45.5 µM -0.195976335491327 0.436248511508433 no 1909 0.422314344185011 2886 16413835 SGTC_3326 9140064 16.379 µM -0.196700019013338 0.435927347534906 no 1910 0.42203114760701 2732 1868434 SGTC_2643 anethole 100 µM -0.197144624168743 0.435730056864726 no 1911 0.421857181784847 2791 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1668 st014914 51.6 µM -0.197402065176445 0.435615826386365 no 1912 0.421756456820668 2758 2839556 SGTC_2575 plumbagin 510 nM -0.197747728342865 0.43546245884851 no 1913 0.421621222587491 2730 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3224 9130643 49.47 µM -0.197867715336371 0.435409224001778 no 1914 0.42157428208627 2950 17644395 SGTC_198 3454-2873 16.191 µM -0.200481784657682 0.434249727304586 no 1915 0.420551901274182 2753 710957 SGTC_1550 gossypolone 36.6 µM -0.201549754757309 0.433776180562872 no 1916 0.420134364436703 2772 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1033 k072-0102 21.3 µM -0.202089903747868 0.4335367101961 no 1917 0.419923220335738 2928 5965931 SGTC_1192 1488-0095 21.4 µM -0.202875185899336 0.43318860570985 no 1918 0.419616294870613 2841 915875 SGTC_124 0136-0217 7.121 µM -0.203898336808703 0.432735135159961 no 1919 0.419216472406368 2864 3976905 SGTC_1789 tunicamycin 25 nM -0.204350507128271 0.432534757011323 no 1920 0.419039801804763 2874 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2113 5491891 107.031 µM -0.204842256653337 0.43231685913177 no 1921 0.418847685468059 2790 789979 SGTC_3296 9122258 64.045 µM -0.206396055666656 0.431628494792421 no 1922 0.418240775814372 2879 4730474 SGTC_248 streptozotocin 5.23457 mM -0.20686339269682 0.431421495559932 no 1923 0.418058273249686 2857 5300 DNA alkylating agent. SGTC_1034 k072-0165 12.7 µM -0.207400557886066 0.431183590362342 no 1924 0.417848523471069 2957 5835461 SGTC_1384 3089-0840 101 µM -0.207596059253059 0.431097010914984 no 1925 0.417772190798165 2869 1069836 SGTC_2190 6049624 200 µM -0.208652916220434 0.430629030226919 no 1926 0.417359599224307 2757 2265554 SGTC_2875 9039966 71.43 µM -0.209246735364751 0.430366127321662 no 1927 0.4171278151463 2871 6463691 SGTC_1776 st049249 45.9 µM -0.210030682044909 0.430019096105512 no 1928 0.41682186313732 2814 1822314 SGTC_2342 7990637 118.86 µM -0.211510668645645 0.42936409509073 no 1929 0.416244404073946 2891 2033102 YER133W GLC7 SGTC_71 0417-1750 47.813 µM -0.212208468452283 0.429055335587207 no 1930 0.415972200162279 2996 6811472 SGTC_318 1488-0629 67.2 µM -0.212673681516283 0.428849514183454 no 1931 0.415790748126008 2860 3662576 SGTC_2010 4012422 159 µM -0.212812587161914 0.42878806274652 no 1932 0.415736572747203 2863 952393 SGTC_2465 5809242 33.21 µM -0.214473837511525 0.428053264812032 no 1933 0.415088783461917 2767 2731748 SGTC_1511 0906-3109 28.5 µM -0.214794522700846 0.427911449200562 no 1934 0.414963761743398 2753 2882180 SGTC_456 gingerol 170 µM -0.216035756585608 0.427362630140378 no 1935 0.41447993794062 2967 442793 A herb. SGTC_1502 4534-4282 27.7 µM -0.216965616165962 0.426951579128968 no 1936 0.414117570493344 2818 3278949 SGTC_2932 9016711 44.54 µM -0.217901481834047 0.426537953161679 no 1937 0.413752936275909 2896 7117328 SGTC_2653 dihydrofissinolide 100 µM -0.218195264879273 0.426408126062106 no 1938 0.413638487142987 2847 6857746 SGTC_1751 st044839 27.194 µM -0.218270427361777 0.426374911923035 no 1939 0.413609207254441 2747 5291326 SGTC_1760 st045453 10.4495 µM -0.218317909615838 0.426353929886386 no 1940 0.413590710572948 2882 3323419 YIL048W NEO1 SGTC_3195 9113082 49.47 µM -0.218695166408951 0.426187230472637 no 1941 0.413443757249031 2820 17018038 SGTC_2305 7443522 69.23 µM -0.219590161390846 0.425791809582556 no 1942 0.41309517723725 2807 5415886 SGTC_2327 6189656 200 µM -0.219738818784241 0.425726137950265 no 1943 0.413037285219815 2915 5349088 SGTC_1167 k781-0610 148 µM -0.220894212573526 0.425215795789019 no 1944 0.412587401909699 2858 4525169 SGTC_228 caffeine 993.056 µM -0.220911606610076 0.425208113727105 no 1945 0.412580629954561 2927 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3155 9099265 49.47 µM -0.222484692907386 0.424513479227125 no 1946 0.411968293987842 2902 25236499 SGTC_701 4424-0219 185 µM -0.222714461425383 0.424412038917981 no 1947 0.411878872721051 2955 2911779 SGTC_1308 1187-1617 41.4 µM -0.224852920891699 0.423468173259877 no 1948 0.411046847554345 2774 2882570 SGTC_1552 6-methylflavone 10.6 µM -0.224856230209333 0.423466712943805 no 1949 0.411045560284351 2814 689013 SGTC_1111 tnp00062 510.699 nM -0.225529164904458 0.423169786178297 no 1950 0.410783819703759 2945 676306 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.226009923365782 0.422957682268628 no 1951 0.410596851139212 3017 165506 SGTC_86 0417-1630 471.922 µM -0.226723133363058 0.422643065145229 no 1952 0.410319518833303 2816 3634867 SGTC_2341 7987486 176.74 µM -0.226919590885249 0.422556410828687 no 1953 0.410243134032349 2947 1258686 SGTC_2031 5180455 200 µM -0.226995695446577 0.422522843313109 no 1954 0.410213544673973 2803 29949 SGTC_2261 9010538 184.68 µM -0.227640720985577 0.42223836386532 no 1955 0.40996278009219 2936 6457250 SGTC_277 nystatin 15.5 µM -0.227740511293682 0.422194356371943 no 1956 0.409923988209199 2764 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_848 0368-0089 85.6 µM -0.230790270680921 0.420849884495264 no 1957 0.408738870042975 2934 762535 SGTC_63 0099-0242 26.702 µM -0.232446931359323 0.42011993923681 no 1958 0.408095450501739 2972 3898502 YLR359W ADE13 SGTC_161 4065-0411 162.148 µM -0.233218948118352 0.41977987274106 no 1959 0.407795696509383 2950 1906281 YLR208W SEC13 SGTC_2389 9091542 195.52 µM -0.234464338812628 0.419231415593612 no 1960 0.407312257569626 2881 3626624 YOL127W RPL25 SGTC_1319 1306-0155 43.7 µM -0.235363694190007 0.418835446312281 no 1961 0.406963231228026 2818 3122360 SGTC_2234 tolnaftate 200 µM -0.235544063240304 0.418756043091596 no 1962 0.406893241587936 2854 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1750 st081859 2.357 µM -0.235654521486381 0.418707418087628 no 1963 0.406850381307246 2851 5291695 SGTC_2087 5276107 200 µM -0.237250183163963 0.41800512819139 no 1964 0.406231353445078 2800 144405 SGTC_2090 5301565 104.445 µM -0.237310238573757 0.417978701420298 no 1965 0.406208059856601 2840 2056344 SGTC_768 0384-0033 77.3 µM -0.239433039737899 0.417044823151717 no 1966 0.405384906460455 2847 3965305 YMR134W ERG29 SGTC_1461 k072-0203 53.8 µM -0.241797654839494 0.416005115341727 no 1967 0.404468478084611 2791 5418714 SGTC_466 geldanamycin 89.2 µM -0.243157771601906 0.415407345449241 no 1968 0.403941589293716 2907 5288382 HSP90 inhibitor. SGTC_1195 1502-0147 41.1 µM -0.243789581491118 0.415129732160098 no 1969 0.403696894846924 2838 817940 SGTC_691 1548-0686 185 µM -0.244834162402309 0.414670842876379 no 1970 0.403292420497803 2862 46495133 SGTC_1243 0416-0003 5.65 µM -0.245181999555794 0.414518062194602 no 1971 0.403157756684236 2895 2141977 SGTC_441 propafenone 146 µM -0.245555474745613 0.414354034902485 no 1972 0.403013179989102 2821 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_359 0081-0058 15.9 µM -0.246644917724517 0.413875645759489 no 1973 0.402591519448944 3248 3494159 SGTC_1597 7-benzyloxygramine 47.5 µM -0.249878002518182 0.412456709415696 no 1974 0.401340847572882 2836 260807 SGTC_2764 methyldopa 94.69 µM -0.250121468314421 0.412349903203962 no 1975 0.401246707105935 3017 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1416 3966-0321 25.3 µM -0.251058410441471 0.411938935906655 no 1976 0.400884474961269 2911 582530 YLR208W SEC13 SGTC_618 k072-0232 33.2 µM -0.253157983602805 0.411018359550417 no 1977 0.400073066669479 2950 5872756 YGL099W LSG1 SGTC_2949 9072542 2.23 µM -0.253945371333252 0.410673248480176 no 1978 0.399768881078407 2959 16457352 SGTC_1667 st014849 34.6 µM -0.254302503399791 0.410516740713105 no 1979 0.399630932965407 2817 5348460 SGTC_2927 9011802 47.9 µM -0.254464453663652 0.410445773135206 no 1980 0.399568381149762 2961 43912568 SGTC_551 k048-0028 34.9 µM -0.256034232086355 0.409758039099692 no 1981 0.39896220233668 3019 6836383 SGTC_2823 7987624 58.44 µM -0.256068354522843 0.409743092828148 no 1982 0.398949028464815 3081 2239440 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.256773072652681 0.409434442335551 no 1983 0.398676979093145 2869 688664 SGTC_2594 a-mangostin 100 µM -0.257047946503258 0.409314069053909 no 1984 0.398570880134987 3032 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1798 st045719 60.953 µM -0.257398193998216 0.40916070039145 no 1985 0.398435698456386 2861 3980186 SGTC_2206 7254556 146.969 µM -0.260198868630826 0.407934824690655 no 1986 0.397355188458075 2905 4398905 SGTC_165 k038-0023 64.381 µM -0.260719265703898 0.407707141971903 no 1987 0.3971545039395 2880 46368543 SGTC_2889 9059656 51.95 µM -0.260794808768532 0.407674093163659 no 1988 0.397125373978373 2959 3949838 SGTC_2906 7926292 26.41 µM -0.261041364540255 0.407566233772213 no 1989 0.397030304254034 3002 2966319 SGTC_2394 5221648 200 µM -0.261781896728369 0.407242319404366 no 1990 0.396744798402098 2994 788586 SGTC_1925 st057770 10.1 µM -0.262143645536394 0.407084110789965 no 1991 0.396605349354343 2874 5989122 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.262961114920286 0.406726651458448 no 1992 0.39629027520185 2961 6708739 YPR165W RHO1 SGTC_720 r052-1644 49.9 µM -0.263793125225015 0.406362913522499 no 1993 0.395969666137615 2995 1422863 YOR257W CDC31 SGTC_881 0833-0569 170 µM -0.263896309710957 0.406317808994439 no 1994 0.395929909653084 2884 5418700 SGTC_756 0508-1999 28.3 µM -0.264817343046276 0.405915257350312 no 1995 0.395575087957125 2878 6753853 SGTC_2638 epoxomicin 18 µM -0.265919413674785 0.40543371133568 no 1996 0.395150636642467 2983 9915668 A protesome inhibitor. SGTC_1472 k841-0093 193 µM -0.266821999751766 0.405039435974039 no 1997 0.394803107397245 2976 X1472 SGTC_3008 9078912 71.4286 µM -0.266986100219965 0.404967762547114 no 1998 0.394739931590005 2910 16648731 SGTC_1014 4130-3005 69.3 µM -0.26740953265901 0.40478283658645 no 1999 0.394576930303301 2861 743608 SGTC_2626 ethyl orsellinate 100 µM -0.269426450400858 0.403902279163918 no 2000 0.393800766988608 2860 75653 A natural product. SGTC_1108 betulinic acid 729.144 nM -0.269428040551484 0.403901585118369 no 2001 0.393800155222538 2919 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_324 1315-0088 19.6 µM -0.270023077513763 0.403641893396963 no 2002 0.393571249771757 2959 6787421 SGTC_2762 leflunomide 42.06 µM -0.270187092063339 0.403570320061342 no 2003 0.393508161289068 2881 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2872 9044037 25.97 µM -0.270810856192036 0.403298148850242 no 2004 0.393268254875868 2854 6465195 SGTC_1299 1079-1439 3.74 µM -0.271309588320705 0.403080567382457 no 2005 0.393076466266911 2913 323161 SGTC_924 2046-0044 21.3 µM -0.271410581841917 0.403036510670646 no 2006 0.393037632129621 2842 3623589 SGTC_1709 st033179 39.1045 µM -0.271583780908701 0.40296095837935 no 2007 0.392971035916631 2888 573381 SGTC_2597 laccaic acid a 100 µM -0.273161511821437 0.402272893271118 no 2008 0.39236453217102 3026 5491415 A textile dye. SGTC_2051 5263410 176 µM -0.274234035249477 0.401805327168602 no 2009 0.391952386984505 2922 227584 SGTC_2779 methotrexate 400 µM -0.274408265750881 0.401729384710511 no 2010 0.391885445788525 2976 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1794 st048918 76.9 µM -0.274784097652128 0.401565582184214 no 2011 0.391741058108833 2970 672303 SGTC_1422 4031-0024 15.5 µM -0.274833207338805 0.401544179501803 no 2012 0.3917221921747 2946 782427 SGTC_997 3996-0078 137 µM -0.275009438719279 0.401467377854608 no 2013 0.391654493378925 2946 735687 SGTC_1179 1021-1431 9.29 µM -0.276608654612173 0.400770613796898 no 2014 0.391040309245726 2962 2840958 SGTC_579 4491-1009 110 µM -0.276940459985866 0.400626088620851 no 2015 0.390912912275919 2996 1271041 SGTC_314 1671-0008 2.74 µM -0.277328077734943 0.400457270357749 no 2016 0.390764100920804 2886 3913060 SGTC_953 1188-0045 9.7 µM -0.277382622813864 0.400433515957152 no 2017 0.390743161658674 3010 6144426 SGTC_1897 st060201 15 µM -0.277464950338169 0.400397662989498 no 2018 0.390711557618111 2920 611878 SGTC_1940 st075990 51.1 µM -0.277484282885504 0.400389243943944 no 2019 0.390704136309151 3148 1084979 SGTC_2557 derrustone 83.84 µM -0.278142378680848 0.400102680344461 no 2020 0.390451532615303 3022 629853 An antioxidant. SGTC_9 0092-0002 10.449 µM -0.278732656496762 0.399845693397663 no 2021 0.390224999525 2940 759368 SGTC_1247 0448-0043 5.84 µM -0.278763932949925 0.399832077899463 no 2022 0.390212997484462 3017 3089013 YGL099W LSG1 SGTC_2351 9026858 72.31 µM -0.279532420935465 0.399497572292196 no 2023 0.389918130450922 2868 1409300 SGTC_1724 st037281 8.293 µM -0.280050511370158 0.399272100741466 no 2024 0.389719376101815 2875 574124 YDL195W SEC31 SGTC_506 n9-isopropylolomoucine 153 µM -0.280282559503397 0.399171124913026 no 2025 0.389630365129912 3048 6610355 SGTC_2648 atorvastatin 78.68 µM -0.280593145766793 0.399035983747513 no 2026 0.389511236902745 3003 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_25 0118-0223 35.662 µM -0.280690190601779 0.398993760432264 no 2027 0.389474016588966 3047 5333628 SGTC_2677 mitomycin C 100 µM -0.281487241162735 0.398647015821971 no 2028 0.389168356359083 2927 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_640 3381-0960 37.1 µM -0.281801610022194 0.398510276456703 no 2029 0.389047818163331 2969 1745025 SGTC_2618 avocadyne 43.43 µM -0.28286765372485 0.398046677902406 no 2030 0.388639145458995 2873 3015189 SGTC_3038 9091290 49.47 µM -0.283028757615846 0.397976629925418 no 2031 0.388577396256224 3061 25236843 SGTC_2522 biochanin a 4.94 µM -0.28313391548574 0.397930909053842 no 2032 0.388537092015649 3027 5280373 A possible chelator. SGTC_1764 st044502 93.5 µM -0.283752404478869 0.397662028836703 no 2033 0.388300065779687 3036 8407 SGTC_3228 9131799 49.47 µM -0.285254027671888 0.397009419783683 no 2034 0.387724765418807 2961 17015818 SGTC_94 0334-0113 514.748 µM -0.285428483408347 0.396933619558666 no 2035 0.38765794406483 2934 6795178 SGTC_483 fpl-64176 144 µM -0.286236775365456 0.396582471230593 no 2036 0.38734838942398 2911 3423 SGTC_3291 9121177 71.43 µM -0.286758083665918 0.396356042406313 no 2037 0.387148779979038 2956 17015612 SGTC_1600 coumarin 106 71.1 µM -0.286760499312223 0.396354993258298 no 2038 0.387147855095178 3079 100336 A hepatotoxic, DNA x-linker. SGTC_2163 5671233 125 µM -0.287492560205029 0.396037083876768 no 2039 0.386867598856827 3121 701023 SGTC_1283 0922-0125 16.4 µM -0.289979387798602 0.394957655930154 no 2040 0.385916003292055 3025 3360884 SGTC_3127 9126946 49.47 µM -0.290546901083193 0.394711434746198 no 2041 0.38569893776715 3002 27243249 SGTC_3184 9108758 49.47 µM -0.290902947759457 0.394556981876757 no 2042 0.385562773390672 2856 902885 SGTC_3272 9137413 49.47 µM -0.291603017678985 0.394253340251282 no 2043 0.385295083947828 2881 17614870 SGTC_348 k064-0012 10.7 µM -0.291937552956735 0.394108264799155 no 2044 0.385167185208611 2877 5066323 SGTC_191 3914-0123 66.505 µM -0.2922229078939 0.393984528632881 no 2045 0.385058098851879 2897 3144412 SGTC_1236 0330-0013 258 µM -0.292601619314116 0.393820327572733 no 2046 0.384913337941697 2957 4617066 SGTC_1636 st007707 68.9 µM -0.292732437635723 0.393763611969933 no 2047 0.384863336893256 3123 403051 SGTC_1032 k061-1018 98.7 µM -0.293100101184111 0.393604225421332 no 2048 0.38472281971584 3117 4005393 SGTC_1896 st058441 89 µM -0.293779795107181 0.393309616925828 no 2049 0.384463087663595 2972 688759 SGTC_126 0417-1624 672.48 µM -0.29524052638324 0.392676680239213 no 2050 0.38390507272621 3018 41912 YDL195W SEC31 SGTC_1937 st074714 47.2 µM -0.295836119066503 0.392418690513414 no 2051 0.383677618953858 2880 17250970 SGTC_1489 4065-0444 182 µM -0.296602500089325 0.392086790870423 no 2052 0.383385000963936 3060 2877968 SGTC_69 0096-0274 206.684 µM -0.297215637338998 0.391821313622466 no 2053 0.383150942070704 3206 6741392 SGTC_2143 5623677 140.463 µM -0.298261693049691 0.391368506891329 no 2054 0.382751719464032 2935 5375313 SGTC_2524 avocatin b 10.57 µM -0.298571524214298 0.391234418322427 no 2055 0.382633497637469 3032 6710748 SGTC_1753 st043925 64 µM -0.299797978374675 0.39070376113301 no 2056 0.382165628731751 3046 670181 SGTC_1849 st056239 19.2 µM -0.300280726788464 0.390494943271818 no 2057 0.381981516544168 2919 5393181 SGTC_1803 st050068 52.4 µM -0.300393801294321 0.390446036277951 no 2058 0.381938395671025 2994 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_726 3448-4391 34.2 µM -0.300411234684601 0.390438496140874 no 2059 0.381931747591769 3119 1356692 SGTC_3085 9117376 49.47 µM -0.301558369850618 0.389942437990325 no 2060 0.381494373687866 3015 16480349 SGTC_986 1493-0483 84 µM -0.304737225851786 0.388568736987093 no 2061 0.380283147560696 3055 40079 SGTC_3352 9151559 45.5865 µM -0.304881490738626 0.388506427706821 no 2062 0.380228206653375 3024 17159339 SGTC_774 k060-0086 136 µM -0.304911833898689 0.388493322592791 no 2063 0.380216651267903 3119 5911235 SGTC_2303 7774051 200 µM -0.304914226477592 0.388492289250995 no 2064 0.380215740122411 3135 2953184 SGTC_1011 4112-3381 17.4 µM -0.305329267724732 0.388313047145206 no 2065 0.38005769355406 3110 2877139 SGTC_845 0330-0138 4.51 µM -0.305531374531878 0.388225772742732 no 2066 0.379980739085417 3017 9039800 SGTC_3098 9119039 49.47 µM -0.305857575234154 0.388084923628494 no 2067 0.379856544478017 2920 17161528 SGTC_934 2950-0684 338 µM -0.306176624507563 0.38794717664511 no 2068 0.379735084624653 3144 1121253 SGTC_2711 st079103 59.1 µM -0.30644705518351 0.387830431392502 no 2069 0.37963214282499 2998 54693780 SGTC_46 0329-0187a 2.197 µM -0.308582980093067 0.386908707080295 no 2070 0.378819384667198 3041 46494817 SGTC_2671 danthron 100 µM -0.308671343081778 0.386870589138144 no 2071 0.37878577246014 2997 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_825 1988-2224 89.6 µM -0.310122119954635 0.386244910672422 no 2072 0.378234045831808 2944 1180859 SGTC_2947 9072639 7.68 µM -0.310181379452119 0.38621936002531 no 2073 0.378211514869293 3026 16488146 SGTC_2647 atorvastatin 60.16 µM -0.310568712167869 0.386052367703211 no 2074 0.378064257895606 3016 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1892 st058411 7.36 µM -0.311517464151488 0.385643417657646 no 2075 0.377703634224944 3072 3934738 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.312828196559336 0.385078648720766 no 2076 0.377205596008412 3027 1377 SGTC_183 3914-0051 30.55 µM -0.312991880427622 0.38500813763819 no 2077 0.37714341547054 3103 1596232 SGTC_866 0495-0101 262 µM -0.313673552291742 0.384714530672433 no 2078 0.376884494946358 2941 635694 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.315960949726648 0.383729796021817 no 2079 0.376016074242961 3063 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_969 1313-0238 134 µM -0.317189702404007 0.383201121993101 no 2080 0.375549831553199 2968 5212874 SGTC_1154 4088-0362 150 µM -0.318593884118984 0.382597235436825 no 2081 0.375017245865948 2944 6618304 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.3191045089617 0.382377705274966 no 2082 0.374823632306752 3038 17037758 SGTC_1881 5652484 16 µM -0.319122273384643 0.382370068593195 no 2083 0.374816897140227 3115 2255129 SGTC_2512 diallyl trisulfide 49.23 µM -0.319936442349469 0.382020117665094 no 2084 0.374508255811367 3013 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_757 1066-0008 322 µM -0.320667912511866 0.381705795000716 no 2085 0.374231033116891 3116 6842497 SGTC_1350 1495-0454 146 µM -0.320802492733039 0.381647972539304 no 2086 0.374180035118118 3126 1069057 SGTC_1186 1319-0216 26 µM -0.322166208761395 0.381062200414824 no 2087 0.373663391179863 3125 4565136 SGTC_3146 9095609 49.47 µM -0.322320262148983 0.380996045250642 no 2088 0.373605042290209 3020 17173999 SGTC_595 3909-8003 73.7 µM -0.322763493572374 0.380805727735221 no 2089 0.373437181188474 3104 699517 SGTC_2223 6903751 107.57 µM -0.322847326488131 0.380769734268446 no 2090 0.373405434592062 3059 5598863 SGTC_1488 4013-0813 75.9 µM -0.323193577458873 0.380621083157483 no 2091 0.373274322290838 2976 2910057 SGTC_202 3594-0513 34.79 µM -0.323459631522664 0.380506873840646 no 2092 0.373173587527901 2982 708429 SGTC_2483 5729050 27.16 µM -0.324087074224775 0.380237572088043 no 2093 0.372936056272725 3149 2865180 SGTC_889 0919-1524 82.7 µM -0.324290242305132 0.380150383699163 no 2094 0.372859153191729 3033 3905452 SGTC_2810 7959871 45.46 µM -0.324506939626701 0.380057396027658 no 2095 0.372777134613078 3070 2974535 SGTC_2654 protoveratrine a 100 µM -0.327079448952056 0.378954029514506 no 2096 0.371803897534028 2994 5702278 A heart drug and vasodilator. SGTC_2416 tofa 880 nM -0.327391119452476 0.378820418708256 no 2097 0.371686041180617 2978 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_952 1185-0122 232 µM -0.328854778812883 0.378193152835324 no 2098 0.371132728071404 2940 678600 SGTC_2504 purpurogallin 52.29 µM -0.329241766504509 0.37802735895934 no 2099 0.370986478001177 2947 5281571 An antioxidant. SGTC_2773 thioridazine 9.09 µM -0.33192319868326 0.37687919409745 no 2100 0.369973626260478 3004 5452 An antipsychotic. SGTC_1480 1070-0044 41.2 µM -0.331982747071565 0.376853708331499 no 2101 0.369951143376459 3059 3124987 SGTC_2214 7179297 48.276 µM -0.332162221723446 0.376776899272553 no 2102 0.369883384234931 3007 769744 SGTC_47 0149-0135 24.25 µM -0.332292558478889 0.376721122622149 no 2103 0.369834179223613 2979 5239155 SGTC_1433 4060-0023 7.6 µM -0.332801736923008 0.376503248145433 no 2104 0.369641973516942 3100 3840627 SGTC_884 0851-0618 334 µM -0.334111332646019 0.375943060646078 no 2105 0.369147774386926 3114 9642473 SGTC_256 clotrimazole 625 nM -0.335059394912517 0.375537684268433 no 2106 0.368790141168109 3069 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2356 9061756 188.97 µM -0.3366335829144 0.37486489006599 no 2107 0.368196568404682 3060 20104043 SGTC_1960 st011366 51.8 µM -0.336929175628985 0.374738598709665 no 2108 0.368085145472867 2982 3972846 SGTC_1703 st026983 48.3 µM -0.33713860647408 0.374649127957717 no 2109 0.368006207757125 3145 1104023 SGTC_285 1486-1325 46 µM -0.337654807715931 0.374428630938256 no 2110 0.367811667351787 3109 22310230 SGTC_3108 9121785 49.47 µM -0.337723735983346 0.374399191113265 no 2111 0.367785692968202 2926 17140271 SGTC_3256 9138902 49.47 µM -0.337812599322857 0.374361237937042 no 2112 0.36775220730184 3009 17228773 SGTC_2383 9036125 200 µM -0.338488325725641 0.374072677748746 no 2113 0.367497611589095 2999 79580 SGTC_85 0868-0259 160.055 µM -0.339182497173533 0.373776314304294 no 2114 0.36723612690717 3049 83173 SGTC_1606 st000094 49.2 µM -0.33963573223845 0.373582854367842 no 2115 0.367065432804096 3149 1242210 SGTC_3022 9087993 49.47 µM -0.339934914403979 0.373455168187982 no 2116 0.366952771380719 3090 17173644 SGTC_2513 baicalein 25.65 µM -0.34001299629289 0.373421846367658 no 2117 0.366923370387545 3045 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1356 1502-0781 85.8 µM -0.342068748336288 0.372544885519934 no 2118 0.366149577778484 3010 567702 SGTC_1036 k216-0215 33.5 µM -0.344549347396618 0.371487569116981 no 2119 0.365216595640434 2984 622330 SGTC_3349 9149703 23.001 µM -0.345352980123929 0.371145240688572 no 2120 0.364914510726934 2982 4910494 SGTC_2250 alverine citrate 130 µM -0.345583598053419 0.371047021746312 no 2121 0.36482783709984 3009 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_668 1682-0499 62.6 µM -0.345933755692424 0.370897907542317 no 2122 0.364696249816743 3051 682214 SGTC_251 melphalan 456.522 µM -0.34656256578059 0.370630178209046 no 2123 0.364459986521159 3079 460612 A DNA alkylator. SGTC_471 1-acyl-paf 4 µM -0.347877439548136 0.370070545162438 no 2124 0.363966114466952 3013 16759367 SGTC_820 1582-0060 59.9 µM -0.34976778367496 0.369266464049948 no 2125 0.36325648929912 3042 3848840 SGTC_900 1112-0045 141 µM -0.351001221327513 0.368742114116378 no 2126 0.362793716068729 3057 56211 YIL048W NEO1 SGTC_2452 5863136 48.41 µM -0.353160070148296 0.367824948587495 no 2127 0.361984220489986 2986 2184096 SGTC_2902 5787006 60.46 µM -0.353458458883802 0.367698240214383 no 2128 0.361872383220544 3002 591003 SGTC_2822 7994718 71.43 µM -0.353636560244347 0.367622617767172 no 2129 0.361805635751851 3024 1018011 SGTC_376 3970-0862 59.1 µM -0.353883245603492 0.367517882797363 no 2130 0.361713191839736 3146 3135186 SGTC_497 capsazepine 133 µM -0.354048430844223 0.367447755763369 no 2131 0.36165129413655 3044 2733484 A calcium channel blocker. SGTC_869 0564-0080 44.1 µM -0.354857775088932 0.367104224152989 no 2132 0.361348071506855 3062 6843321 SGTC_98 0074-0023 107.663 µM -0.35505059076656 0.36702239792047 no 2133 0.361275845518993 3099 3563821 SGTC_439 amiodarone 34.4 µM -0.356571424877639 0.366377205311383 no 2134 0.360706336359247 3040 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1232 0279-0259 161 µM -0.356754792119972 0.366299439788548 no 2135 0.360637691372058 3075 1560000 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.357454902098717 0.366002575673516 no 2136 0.360375640946748 3154 5024745 SGTC_794 k038-0031 316 µM -0.357664926184209 0.365913535846662 no 2137 0.360297041934223 3107 6624242 SGTC_907 3448-6986 75.5 µM -0.359061044146171 0.365321834634954 no 2138 0.359774711626508 3214 590582 SGTC_2157 5649910 96.377 µM -0.360017774992825 0.364916538933187 no 2139 0.359416920544946 3027 2858091 SGTC_790 1575-0012 79.1 µM -0.361199012549489 0.364416344621167 no 2140 0.358975340125437 3186 378741 YLR208W SEC13 SGTC_1486 3970-0793 4.53 µM -0.361732394322895 0.364190560022696 no 2141 0.358776008445687 3124 2844330 SGTC_3088 9117578 49.47 µM -0.362360668998711 0.36392466698309 no 2142 0.358541263389097 3125 678341 SGTC_411 enrofloxacin 100 µM -0.365618026896315 0.362547168582775 no 2143 0.357325060807374 3209 71188 A bacterial gyrase inhibitor. SGTC_2751 anetholtrithion 17.25 µM -0.365689097171404 0.362517133547563 no 2144 0.357298541332065 3169 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_179 1273-0063 6.77 µM -0.366036865927554 0.362370175067961 no 2145 0.35716878330745 3038 3108139 SGTC_2971 9092186 9.93 µM -0.369390481431203 0.360954063650565 no 2146 0.355918345910935 3013 25236400 SGTC_486 niguldipine 82 µM -0.371188529380912 0.360195595298314 no 2147 0.35524855802461 3057 1236 A calcium channel blocker. SGTC_1898 st060199 18.6 µM -0.371608740547708 0.36001841731204 no 2148 0.355092090207019 3031 688866 SGTC_2432 5630864 12.22 µM -0.371636401757972 0.360006755283897 no 2149 0.355081791268028 3182 5714970 SGTC_1520 flindersine 88 µM -0.371662469485954 0.359995765190708 no 2150 0.355072085718009 3305 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_206 4546-0025 72.014 µM -0.371672139514699 0.359991688358619 no 2151 0.355068485391795 3136 6620745 YIL048W NEO1 SGTC_1144 3486-0183 12.5 µM -0.373553677416355 0.359198745641097 no 2152 0.354368201435805 3074 6744069 SGTC_2540 epiandrosterone 100 µM -0.374308366299815 0.358880864738715 no 2153 0.354087454176573 3070 441302 A steroid. SGTC_287 k060-0039 29.6 µM -0.374454057621273 0.358819509651528 no 2154 0.354033265554202 3195 5861974 SGTC_2308 7584454 197.62 µM -0.375755602864469 0.358271550795233 no 2155 0.353549298383404 3246 893577 SGTC_2478 5763493 32.33 µM -0.375809853847371 0.358248717111449 no 2156 0.353529130805766 3049 1365576 YLR208W SEC13 SGTC_3062 9077494 49.47 µM -0.377782876538376 0.357418637101319 no 2157 0.352795947619341 3184 16459633 SGTC_3166 9102297 49.47 µM -0.379369837965558 0.356751467761724 no 2158 0.352206622649783 3110 25237072 SGTC_2975 9084847 53.72 µM -0.380247910459217 0.356382508203349 no 2159 0.351880698982055 3151 27211724 SGTC_1321 1326-2144 215 µM -0.380645792267545 0.356215365437898 no 2160 0.351733048694611 3173 3513030 SGTC_2798 7813637 45.45 µM -0.38134668463209 0.3559210007615 no 2161 0.351473008370402 3199 956368 SGTC_2505 galangin 7.89 µM -0.38150557503396 0.355854281020183 no 2162 0.351414067591773 3002 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1021 4476-0760 85.3 µM -0.381647690534322 0.355794608975672 no 2163 0.351361352530227 3078 746768 SGTC_1158 4092-0494 91.8 µM -0.38217295097914 0.355574091118112 no 2164 0.351166541904733 3216 1148199 SGTC_2166 5933061 31.504 µM -0.382229850347855 0.35555020619842 no 2165 0.351145441193287 3516 2877375 SGTC_1224 0823-0416 294 µM -0.382491471619029 0.355440391489594 no 2166 0.351048426780302 3207 3598164 SGTC_689 0833-0039 98 µM -0.384341432163479 0.354664219263193 no 2167 0.350362701660183 3124 5374726 SGTC_1262 0737-0114 49.6 µM -0.38466350410119 0.354529151816809 no 2168 0.35024336896874 3245 765919 SGTC_3010 9080089 71.4286 µM -0.385702972516478 0.354093354352749 no 2169 0.349858330561942 3180 17027233 SGTC_2774 tamoxifen 10.92 µM -0.386697338326581 0.353676644939829 no 2170 0.349490143433957 3117 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1402 3909-7673 35.9 µM -0.388503610056771 0.352920138327544 no 2171 0.34882169151524 3065 5328014 SGTC_1826 st055655 41.6 µM -0.391473832057103 0.351677408029502 no 2172 0.347723513725473 3165 676168 SGTC_514 4466-0038 2.65 nM -0.392010754473921 0.351452930195518 no 2173 0.347525133790936 3098 5722064 SGTC_2255 7941087 197.44 µM -0.393351969306094 0.350892418276216 no 2174 0.347029769639869 3241 935561 SGTC_2388 9080168 200 µM -0.393455724741644 0.350849070968759 no 2175 0.346991459495714 3081 15943073 SGTC_402 epigallocatechin gallate 10 µM -0.393679573546659 0.350755557247605 no 2176 0.346908811996674 3105 65064 An antioxidant. SGTC_840 0245-0196 390 µM -0.393848490970423 0.350684997312635 no 2177 0.346846450603301 3239 3827528 SGTC_793 0488-0545 106 µM -0.393866765850566 0.350677363865596 no 2178 0.346839704082074 3065 292548 SGTC_836 0330-0104 1.35 µM -0.393917340273115 0.350656239161658 no 2179 0.346821033820698 3123 46494820 SGTC_2967 9089538 49.85 µM -0.395102019467359 0.350161536327097 no 2180 0.346383799275234 3294 728216 SGTC_1103 duloxetine 36.1 µM -0.395420005103511 0.350028793907505 no 2181 0.346266473784806 3249 60835 A selective serotonin reuptake inhibitor. SGTC_536 3852-0578 10.6 µM -0.396054534062527 0.349763965936543 no 2182 0.346032399063507 3246 2869208 SGTC_3114 9122766 49.47 µM -0.396157120525844 0.349721157153655 no 2183 0.345994560925318 3154 17176985 SGTC_2233 sulbentine 40.3845 µM -0.397579790442152 0.349127681790185 no 2184 0.345469979993775 3161 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_134 0269-0018 6.916 µM -0.397645581112577 0.349100245724588 no 2185 0.345445728175764 3153 4378915 SGTC_3173 9105693 49.47 µM -0.398037585790743 0.348936788048771 no 2186 0.345301240202734 3269 17096658 SGTC_3201 9113999 49.47 µM -0.400169056700054 0.348048500900215 no 2187 0.344516001960322 3261 16649224 SGTC_656 4090-1979 187 µM -0.400409481311049 0.347948356520556 no 2188 0.344427471003279 3238 22330961 SGTC_2192 5915882 198.485 µM -0.400803989143072 0.347784054633984 no 2189 0.344282220831798 3135 2876149 SGTC_1735 st034310 56.75 µM -0.402701763111499 0.34699408280881 no 2190 0.343583818364749 3276 871153 SGTC_2099 5377090 177.372 µM -0.403933999956905 0.346481504602124 no 2191 0.343130626704392 3203 2243829 SGTC_2420 aureobasidin a 50 nM -0.405068811327121 0.346009701334718 no 2192 0.342713465615794 3349 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1628 st004252 77.7 µM -0.405294753460484 0.345915793311275 no 2193 0.342630431276717 3242 692968 SGTC_1569 carminic acid 40.6 µM -0.405428624063752 0.345860157324103 no 2194 0.342581237058388 3280 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3097 9117246 49.47 µM -0.405639619171809 0.34577247551556 no 2195 0.342503706865046 3136 16423892 SGTC_354 2783-3500 4.88 µM -0.405747505836039 0.345727644980631 no 2196 0.342464066453009 3139 6740761 SGTC_3163 9099914 49.47 µM -0.40606583393868 0.345595381564674 no 2197 0.342347114408928 3195 16268368 SGTC_1477 0139-0234 16 µM -0.406300881906165 0.345497732639671 no 2198 0.342260768742689 3168 620880 SGTC_939 1165-0479 45.3 µM -0.406890291447631 0.345252912068704 no 2199 0.342044283425149 3236 1377347 SGTC_2693 st077581 40.7 µM -0.407481344175733 0.345007473983983 no 2200 0.341827246708275 3242 25238761 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.410477415530823 0.343764342615211 no 2201 0.340727883653567 3156 6708561 SGTC_2962 9082311 13.18 µM -0.412046396732163 0.343114012477364 no 2202 0.34015270828954 3077 16459453 SGTC_1806 st050005 60.3 µM -0.414483477498742 0.34210478344949 no 2203 0.339260032459816 3145 5194765 SGTC_1617 st002906 78 µM -0.416035828452859 0.34146252034357 no 2204 0.338691893009666 3131 5150859 SGTC_3306 9127676 59.7925 µM -0.416095200874005 0.341437964948148 no 2205 0.338670170782308 3211 41905287 SGTC_1831 st055328 12 µM -0.417096935784764 0.341023766170895 no 2206 0.338303753068679 3247 1103068 SGTC_123 0083-0120 66.675 µM -0.418627661322222 0.340391209650038 no 2207 0.33774413527165 3157 16001701 SGTC_1856 st057054 55.7 µM -0.419480209359055 0.340039097440626 no 2208 0.3374326076843 3335 1266018 SGTC_2830 7992007 71.43 µM -0.420390391445585 0.339663335637872 no 2209 0.337100143118736 3019 1952075 SGTC_2235 salicylic acid 500 µM -0.420834549683618 0.339480026074386 no 2210 0.336937950452596 3204 338 A COX inhibitor and kinase inhibitor. SGTC_3347 9188721 44.724 µM -0.420967851357017 0.339425018241705 no 2211 0.33688927877283 3207 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1429 4049-0205 9.46 µM -0.421949334249956 0.339020108115334 no 2212 0.336530999653656 3208 22774478 SGTC_547 1120-0019 610 nM -0.422181037095592 0.338924546362366 no 2213 0.336446440809935 3139 3676939 SGTC_3159 9100096 49.47 µM -0.42233949216682 0.338859200329644 no 2214 0.336388618152776 3083 25236875 SGTC_3330 9141424 71.43 µM -0.422943740547293 0.338610056012593 no 2215 0.336168154282968 3255 27261020 SGTC_404 fumagillin 50 µM -0.422991033566378 0.338590559084277 no 2216 0.336150901500068 3218 12015870 A methionine aminopeptidase binder. SGTC_1027 k015-0025 8.67 µM -0.423163493389484 0.338519464797388 no 2217 0.336087990025027 3106 3598955 SGTC_1952 st077036 64.1 µM -0.423165507239421 0.338518634648307 no 2218 0.336087255421503 3204 2937007 SGTC_1961 st076550 68.7 µM -0.423691958484857 0.338301647877436 no 2219 0.335895240278747 3240 1579337 SGTC_176 1486-1328 72.834 µM -0.424751653125555 0.33786503768557 no 2220 0.335508862563099 3208 22310231 SGTC_572 0960-0087 17.7 µM -0.428518956603775 0.336314620761761 no 2221 0.334136667588228 3193 6796365 SGTC_860 0443-0016 25.1 µM -0.429561723848774 0.335885964598624 no 2222 0.333757242609039 3209 5337942 SGTC_3244 9134489 49.47 µM -0.429969167141484 0.335718532554752 no 2223 0.333609034999777 3221 16584271 SGTC_1742 st038235 28.8875 µM -0.430999805597541 0.335295154444684 no 2224 0.333234255919289 3246 564103 YBR002C RER2 SGTC_2611 pyromycin 23.93 µM -0.432127075513582 0.33483232033825 no 2225 0.332824528582168 3172 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_3145 9085516 49.47 µM -0.433802096716615 0.3341450540026 no 2226 0.332216079453276 3243 25236195 SGTC_1859 st055998 20 µM -0.434744180337559 0.333758758220048 no 2227 0.331874062981982 3329 676301 SGTC_962 1254-0300 21.5 µM -0.435842562655248 0.333308595491484 no 2228 0.33147548027498 3146 7340576 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.435867308351644 0.333298456438564 no 2229 0.3314665027135 3292 688801 SGTC_2489 cantharidin 73.42 µM -0.436661031435389 0.332973308969005 no 2230 0.3311785970492 3232 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_215 1287-0124 461.5 µM -0.437618392586936 0.33258129445043 no 2231 0.330831468013686 3192 5560863 SGTC_2178 5812956 200 µM -0.438021694062659 0.332416207736129 no 2232 0.330685278674227 3162 5403383 SGTC_1166 k206-0078 225 µM -0.438446045379729 0.33224253960978 no 2233 0.330531487035871 3173 5404595 SGTC_1774 st048371 48.465 µM -0.439876688103931 0.331657306740686 no 2234 0.330013210410928 3134 4242727 SGTC_493 zm226600 134 µM -0.442089746826244 0.330752820337607 no 2235 0.329212131804011 3333 5240098 A potassium channel opener. YCR052W RSC6 SGTC_118 0083-0097 135.343 µM -0.442410601805895 0.330621767381065 no 2236 0.329096054300786 3267 5207356 SGTC_2738 aclarubicin 5.55 µM -0.442583122168363 0.330551310161095 no 2237 0.329033647453459 3205 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1387 3342-1166 1.8 µM -0.442890032817706 0.33042598286733 no 2238 0.328922638563718 3220 3418228 SGTC_3025 9087895 49.47 µM -0.443371238670664 0.33022952022555 no 2239 0.3287486178692 3301 17173641 SGTC_273 hydroxyurea 18.1 mM -0.443794405024205 0.330056792124864 no 2240 0.32859561694324 3162 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2333 9017922 200 µM -0.444635052051249 0.329713764178157 no 2241 0.32829175606896 3292 3163164 SGTC_2855 9016525 58.44 µM -0.445378428323815 0.329410547067167 no 2242 0.328023149352604 3183 43811474 SGTC_870 0573-2213 57.6 µM -0.44538889143198 0.329406280050656 no 2243 0.328019369315873 3277 3916321 SGTC_1949 st076024 69.1 µM -0.445691507028138 0.32928287836877 no 2244 0.327910050145757 3124 2921930 SGTC_1089 terbinafine 2.25 µM -0.445758514369128 0.329255556387121 no 2245 0.327885845895348 3284 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3129 9127257 49.47 µM -0.446139541043454 0.329100211586246 no 2246 0.32774822598968 3163 837894 SGTC_857 0438-0306 1.35 µM -0.446203767051708 0.32907402950997 no 2247 0.327725031026846 3283 4686136 SGTC_960 1222-0186 7.7 µM -0.44689328046303 0.328792998516747 no 2248 0.327476057939733 3296 3126296 SGTC_2979 9012552 45.46 µM -0.447503185760175 0.328544494751777 no 2249 0.327255894094751 3287 17100905 SGTC_1182 1222-0449 220 µM -0.447768556922286 0.328436393870151 no 2250 0.327160119066499 3252 658318 SGTC_203 k066-0004 30.888 µM -0.448310630668833 0.32821562080382 no 2251 0.326964514760019 3295 6795412 SGTC_1377 2944-0135 198 µM -0.448567287159149 0.328111111960833 no 2252 0.326871918264836 3249 1894137 SGTC_1846 st056244 14.8 µM -0.449211302547189 0.327848932361708 no 2253 0.326639617420657 3232 5393182 SGTC_2440 5628896 157.78 µM -0.452059220184338 0.326690559383692 no 2254 0.325613160282091 3183 5522048 SGTC_1019 4262-0212 3.4 µM -0.452648987711391 0.326450883266703 no 2255 0.32540075890456 3285 4677213 SGTC_2140 5586273 200 µM -0.453871906954979 0.325954128444428 no 2256 0.324960512314085 3282 854421 SGTC_3243 9134147 49.47 µM -0.453883038591146 0.325949608144834 no 2257 0.324956506085701 3293 24282180 SGTC_3273 9137859 49.47 µM -0.454958677484589 0.325512936852721 no 2258 0.324569483770286 3294 2377234 SGTC_1962 st076595 64.5 µM -0.455708087697927 0.325208844296187 no 2259 0.324299952687544 3210 279619 SGTC_710 3448-4187 58 µM -0.455771537810337 0.325183103114285 no 2260 0.324277136596285 3273 3946412 SGTC_2299 7976368 114.88 µM -0.456209725344676 0.325005356862476 no 2261 0.324119586305835 3298 2979718 SGTC_838 0109-0203 71.4 µM -0.458255123244829 0.324176189637455 no 2262 0.323384580641501 3225 759422 SGTC_2488 5268135 45.7 µM -0.458726972611877 0.323985033994756 no 2263 0.323215121094768 3314 1270356 YLR208W SEC13 SGTC_3206 9114350 49.47 µM -0.460036925286636 0.32345458925963 no 2264 0.322744858236031 3287 17087243 SGTC_3057 9095946 49.47 µM -0.460407008332287 0.323304794869426 no 2265 0.322612052588717 3251 24540043 SGTC_670 4204-0025 119 µM -0.461418193576533 0.322895654776843 no 2266 0.322249300499422 3289 719039 SGTC_2862 9027634 71.43 µM -0.461964092139826 0.322674865384817 no 2267 0.322053535437166 3169 5012562 SGTC_3015 9080845 49.47 µM -0.462244201801141 0.32256159892318 no 2268 0.321953104277239 3347 5296973 SGTC_955 1216-0110 33 µM -0.463443713205731 0.322076745175107 no 2269 0.321523175850577 3244 3619719 SGTC_3235 9132602 49.47 µM -0.463535239727148 0.322039761715742 no 2270 0.321490380754284 3345 4912240 SGTC_2404 5161160 200 µM -0.465467949444306 0.321259216561488 no 2271 0.32079819193766 3232 2831543 SGTC_1559 coumarin 343 70.1 µM -0.465501521115536 0.321245665249535 no 2272 0.320786173931475 3354 108770 A hepatotoxic, DNA x-linker. SGTC_131 0141-0277 33.849 µM -0.466762398699945 0.320736880456698 no 2273 0.320334940331252 3339 1547771 SGTC_420 mitomycin C 81.9 mM -0.466979130451834 0.320649459509376 no 2274 0.320257404688873 3206 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_205 1486-1330 71.903 µM -0.46752100474907 0.32043093255517 no 2275 0.320063583855113 3254 4118834 SGTC_791 1348-1292 225 µM -0.46756601627264 0.320412783116207 no 2276 0.320047486072511 3247 5437054 SGTC_2254 7938975 95.19 µM -0.468010526544413 0.320233571816879 no 2277 0.319888530985575 3404 2969277 SGTC_2531 methyl deoxycholate 70.07 µM -0.468834950618933 0.319901303305192 no 2278 0.31959380779914 3171 16667744 Haematoxylin. SGTC_858 0438-0351 2.77 µM -0.469122169162312 0.319785579222454 no 2279 0.319491156846852 3264 2799119 SGTC_430 0958-0115 16.4 µM -0.469227989673614 0.319742947184568 no 2280 0.319453340434101 3203 6833180 SGTC_1157 4092-0394 27.6 µM -0.469579312577306 0.319601426379142 no 2281 0.319327803837425 3412 3659885 SGTC_1378 2093-0007 380 nM -0.471628020957034 0.318776684052865 no 2282 0.318596161166758 3314 3618014 SGTC_2737 bleomycin 30.5 nM -0.471649988248408 0.318767845599105 no 2283 0.318588319947164 3319 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1092 toremifene 6.32 µM -0.473096143368628 0.318186217715747 no 2284 0.318072294069462 3274 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2996 9066192 71.4286 µM -0.474228162405702 0.31773124446081 no 2285 0.317668606359596 3259 6472854 SGTC_3293 9120939 62.045 µM -0.475966925647295 0.317032948681932 no 2286 0.317048970557246 3341 934087 SGTC_2065 5221596 34.26 µM -0.476037832388328 0.317004485990934 no 2287 0.317023712685959 3322 788581 SGTC_1998 st075797 76.8 µM -0.476248829453795 0.316919796016414 no 2288 0.316948557925881 3360 24208315 SGTC_630 4356-0227 183 µM -0.477375207371726 0.316467852954563 no 2289 0.316547482719583 3304 779312 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.477443514204654 0.316440454615818 no 2290 0.316523167282435 3236 641818 YHR062C RPP1 SGTC_2139 5578692 56.4705 µM -0.478123632080984 0.316167709646857 no 2291 0.316281106463806 3302 650991 YMR113W FOL3 SGTC_236 1509-0011 5.31 µM -0.478607964479348 0.315973540702998 no 2292 0.316108775646623 3407 3107280 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.478887351267607 0.315861557571072 no 2293 0.316009384905277 3192 6708514 SGTC_1943 st076331 65.2 µM -0.479179852328871 0.3157443361143 no 2294 0.315905343061405 3357 24208415 SGTC_1727 st034309 9.9045 µM -0.479793348869311 0.315498534106979 no 2295 0.31568717135873 3424 870305 SGTC_3229 9132204 49.47 µM -0.480205683161201 0.31533337512186 no 2296 0.315540573072087 3231 17682924 SGTC_795 0685-0265 78 µM -0.480451458311443 0.315234948336063 no 2297 0.315453205796489 3375 302754 SGTC_799 1310-0557 151 µM -0.48074802626502 0.31511619776506 no 2298 0.315347796610514 3372 5354492 SGTC_664 1222-0054 14.9 µM -0.480961647681648 0.315030672155204 no 2299 0.315271878433249 3291 6813991 SGTC_116 0155-0182 31.788 µM -0.481460863237196 0.314830844558248 no 2300 0.315094494357684 3253 771486 SGTC_1281 0884-0031 11.8 µM -0.481614094787605 0.314769519413162 no 2301 0.315040055811477 3272 1548255 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.481622931492618 0.314765983011243 no 2302 0.315036916519336 3362 7104 SGTC_508 roscovitine 141 µM -0.482997330628319 0.314216162813921 no 2303 0.314548815789813 3318 160355 A CDKinase inhibitor. SGTC_1164 k060-0068 93.7 µM -0.483716599760502 0.31392858761942 no 2304 0.314293505386027 3276 5963676 SGTC_3348 9149464 3.537 µM -0.485321241308518 0.313287433860693 no 2305 0.313724245103215 3316 1951442 SGTC_2174 5790901 200 µM -0.486449257322884 0.312837058958035 no 2306 0.313324336984451 3327 786020 SGTC_2621 lithochol-11-enic acid 100 µM -0.486722304610391 0.312728083265802 no 2307 0.313227568284169 3379 6708711 SGTC_2821 7996764 71.43 µM -0.487693542012683 0.312340586158012 no 2308 0.312883463372198 3462 2987135 SGTC_2777 climbazole 1.536 µM -0.489501208295438 0.311619929434596 no 2309 0.312243449653599 3331 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_792 4534-1957 155 µM -0.490184814900341 0.311347585825077 no 2310 0.312001562580508 3255 1717904 SGTC_2923 7992654 58.14 µM -0.490447319939561 0.311243033257387 no 2311 0.311908699438266 3285 2985126 SGTC_3255 9139072 49.47 µM -0.491277081198372 0.310912649592097 no 2312 0.311615243760696 3346 17646060 SGTC_2939 9044578 71.43 µM -0.491323157686005 0.310894307911753 no 2313 0.311598951725448 3251 2653634 SGTC_2405 ticlatone 3.52 µM -0.491458771138925 0.310840326952984 no 2314 0.311551002746492 3062 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1452 4194-0072 190 µM -0.491485088433265 0.310829851820959 no 2315 0.31154169808565 3396 1343545 SGTC_1777 st045864 34.765 µM -0.492216507767313 0.3105387846989 no 2316 0.311283147908045 3354 4691462 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.492898292135364 0.310267576499826 no 2317 0.311042227050417 3385 688798 SGTC_1902 st060212 70.5 µM -0.493067775184882 0.310200173542757 no 2318 0.310982349703667 3388 688944 SGTC_2359 9039622 200 µM -0.495004665426147 0.309430330691863 no 2319 0.310298413630717 3280 6463596 SGTC_484 loperamide 105 µM -0.495025817652187 0.309421928064291 no 2320 0.310290948174284 3288 3955 An opioid-receptor agonist. SGTC_3087 9117406 49.47 µM -0.495299731266114 0.309313126102383 no 2321 0.310194280297096 3352 42546093 SGTC_140 0062-0056 502.533 µM -0.495433206354264 0.309260114161579 no 2322 0.310147179856671 3239 3758964 SGTC_3275 9138069 49.47 µM -0.496020157800805 0.309027043369245 no 2323 0.309940094494451 3353 17617007 SGTC_2587 piperic acid 92.2 µM -0.497908551816863 0.308277708418139 no 2324 0.309274249708129 3261 5370536 SGTC_1564 D-Arginine 115 µM -0.498236737070588 0.308147562326536 no 2325 0.309158595875186 3294 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2793 7325131 81.82 µM -0.498995939755449 0.307846583168835 no 2326 0.308891122212027 3279 4176441 SGTC_1964 st076914 61 µM -0.499678645608621 0.307576040849612 no 2327 0.308650685552662 3341 24208661 SGTC_1302 1159-0335 255 µM -0.499734871721197 0.307553764256339 no 2328 0.30863088738621 3285 649284 SGTC_3065 9113888 49.47 µM -0.500186043685594 0.30737503716947 no 2329 0.308472042241753 3449 16648368 SGTC_339 3091-4833 71.4 µM -0.500645911379712 0.30719291241998 no 2330 0.30831017245743 3352 3240077 SGTC_3198 9112019 49.47 µM -0.500865969537947 0.307105778003508 no 2331 0.308232726909941 3350 45595555 SGTC_370 0180-0345 38.7 µM -0.501123424530981 0.307003849729571 no 2332 0.308142131047644 3231 3989527 SGTC_1842 st055362 61.2 µM -0.503952005618453 0.305884977684258 no 2333 0.307147551957712 3279 676032 SGTC_2368 9071271 200 µM -0.504357052194397 0.305724905521372 no 2334 0.307005246247822 3301 27209959 SGTC_2161 5662504 8.5105 µM -0.505361578231705 0.305328082602633 no 2335 0.306652449863354 3295 2859334 SGTC_3245 9134821 49.47 µM -0.505845527079246 0.305136987468584 no 2336 0.306482547625951 3284 17014901 SGTC_585 0kpi-0023 191 µM -0.505901263444473 0.305114982461074 no 2337 0.306462982663603 3355 64601 SGTC_2467 5474540 200 µM -0.505911921279702 0.30511077477241 no 2338 0.306459241539792 3274 5413519 SGTC_2880 9042983 58.44 µM -0.506735332816284 0.304785771717482 no 2339 0.306170267817319 3386 6464714 SGTC_2900 5328528 85.29 µM -0.50731226846296 0.304558145175511 no 2340 0.305967865857821 3364 795359 SGTC_1052 3253-3998 198 µM -0.507762186847418 0.304380685047023 no 2341 0.305810065505636 3302 5450317 SGTC_3267 9137951 49.47 µM -0.508164207018964 0.304222156238964 no 2342 0.305669095037526 3251 16643986 SGTC_1956 st077085 54 µM -0.508602989485276 0.30404917292709 no 2343 0.305515266546263 3312 24208685 SGTC_3171 9103192 49.47 µM -0.508834122985817 0.303958069694166 no 2344 0.305434249494475 3413 13018434 SGTC_991 3996-0057 64.7 µM -0.509928077099363 0.303527043623051 no 2345 0.305050925367548 3337 715343 SGTC_1413 3910-0535 34.4 µM -0.510961118355313 0.303120268454832 no 2346 0.304689141494931 3396 2876951 SGTC_232 clozapine 119 µM -0.512843445040875 0.30237970235018 no 2347 0.304030418388296 3343 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1133 3473-0247 50 µM -0.513441827382747 0.302144450153443 no 2348 0.303821146629097 3283 711311 SGTC_581 0958-0271 211 µM -0.513511633976067 0.302117011256077 no 2349 0.303796737413348 3327 4591145 SGTC_1127 asiatic acid 681.4 nM -0.513740372832256 0.302027108649059 no 2350 0.303716760611449 3271 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2319 6033012 152.6 µM -0.514348392881153 0.30178819331235 no 2351 0.303504216723562 3258 847246 SGTC_665 3914-0008 307 µM -0.514638584657153 0.30167419534142 no 2352 0.303402798612002 3299 1069549 SGTC_2728 chlorpromazine 9.18 µM -0.515197520763694 0.301454679330135 no 2353 0.303207500665396 3347 2726 A thorazine and dopamine antagonist. SGTC_1772 st048439 82.2 µM -0.516237490556893 0.301046434067149 no 2354 0.30284427434665 3363 2927068 YDL195W SEC31 SGTC_1809 st050081 57.6 µM -0.516807452640276 0.300822798409163 no 2355 0.302645288527174 3464 5036894 SGTC_2025 5147754 141 µM -0.517038579593632 0.300732132636069 no 2356 0.302564613917147 3339 315777 YLR208W SEC13 SGTC_2181 6316240 54.2555 µM -0.517203071935059 0.300667613596233 no 2357 0.302507203917146 3362 12779990 SGTC_921 1561-0023 372 µM -0.517474453962793 0.300561182738058 no 2358 0.302412498680929 3352 24050882 SGTC_1185 1319-0113 81.3 µM -0.518923188342476 0.299993304767975 no 2359 0.301907153356479 3389 4672763 SGTC_1786 berberine 21.6 µM -0.519470091838368 0.299779054678797 no 2360 0.30171648201042 3363 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.519513749325284 0.299761954793586 no 2361 0.301701263684898 3277 279621 SGTC_3303 9125618 40.5795 µM -0.520110820620071 0.299528136602466 no 2362 0.301493168503446 3351 22695467 SGTC_1172 0370-0043 85 µM -0.520202091137324 0.299492401577778 no 2363 0.301461363999571 3410 376585 SGTC_904 1141-0088 396 µM -0.520774263063088 0.299268423909166 no 2364 0.30126201700425 3350 1378119 SGTC_2446 5162541 200 µM -0.522449733831803 0.298612995541275 no 2365 0.300678618027255 3319 1549321 SGTC_2601 securinine 100 µM -0.522969148203634 0.298409938170959 no 2366 0.300497861522554 3276 442872 A GABA receptor antagonist. SGTC_237 nikkomycin 200 µM -0.523486972213179 0.298207565103569 no 2367 0.300317707333187 3450 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_521 r062-0005 13.8 µM -0.523533248731563 0.298189482617831 no 2368 0.300301609821299 3359 2832033 SGTC_229 benomyl 22.8748 µM -0.525727707461082 0.29733257488562 no 2369 0.299538704867295 3398 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2890 9046729 58.44 µM -0.527389103672373 0.296684570441103 no 2370 0.29896170437171 3286 903329 SGTC_1361 1608-0041 5.61 µM -0.528048390139529 0.296427604300753 no 2371 0.298732875130086 3364 X1361 SGTC_2703 st077852 53.4 µM -0.528227671944679 0.296357744351056 no 2372 0.298670662659323 3407 6281836 SGTC_1847 st056231 15 µM -0.528962448077967 0.296071506274256 no 2373 0.298415750005077 3366 5393180 SGTC_369 0957-0393 4.5 µM -0.529495236801739 0.295864033441493 no 2374 0.298230973903688 3358 6997992 SGTC_1373 2887-0003 58.5 µM -0.529575491407544 0.295832787346874 no 2375 0.298203145373248 3332 776948 SGTC_2982 9019404 25.97 µM -0.530075764762354 0.295638046557652 no 2376 0.298029700724716 3301 22333232 SGTC_2780 5215298 71.43 µM -0.533933656868958 0.294138272960277 no 2377 0.296693717573119 3448 2834131 SGTC_1458 k015-0034 6.33 µM -0.534070222040713 0.294085247101365 no 2378 0.296646475523394 3369 3598957 SGTC_785 1270-0111 65.3 µM -0.534673888068178 0.293850907126851 no 2379 0.296437690355251 3381 6741994 SGTC_918 glabranin 770.725 nM -0.535587861950563 0.293496271763644 no 2380 0.2961217097262 3377 124049 Also referred to as licorice root. SGTC_1944 st076371 56.9 µM -0.53579237270233 0.293416945720128 no 2381 0.296051027081504 3301 24208455 SGTC_1412 3909-8563 178 µM -0.539675713656715 0.291912556237579 no 2382 0.294710345773734 3476 23767530 SGTC_1249 0481-0015 10.2 µM -0.543269995517305 0.290523356482642 no 2383 0.293471959833266 3326 4227577 SGTC_2673 kobusone 100 µM -0.544467531803964 0.290061193532733 no 2384 0.29305989263464 3462 6710676 An epoxy ketone and protein crosslinker. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.544618281507783 0.29000303940967 no 2385 0.293008039320606 3346 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2023 5144124 124 µM -0.544829223212064 0.289921674431143 no 2386 0.292935488934984 3333 2830192 SGTC_2802 7925815 54.55 µM -0.545138096693661 0.289802554272752 no 2387 0.292829271356498 3340 1262923 SGTC_516 3992-2719 87.3 µM -0.545798711186558 0.289547858764612 no 2388 0.292602154648871 3267 5350887 YDR037W KRS1 SGTC_2897 9048598 12.99 µM -0.547144265118392 0.289029414749947 no 2389 0.292139811703048 3342 6467404 SGTC_965 1291-5240 308 µM -0.548257629336001 0.288600764206941 no 2390 0.291757508199854 3458 2834598 SGTC_1053 3366-3204 134 µM -0.548361742758946 0.288560695358377 no 2391 0.291721769982844 3378 3632071 YPR165W RHO1 SGTC_714 4296-0578 26.1 µM -0.548945123613289 0.288336225271027 no 2392 0.291521555060452 3387 1589775 SGTC_1539 benzyladenosine 56 µM -0.549071678082305 0.288287541205918 no 2393 0.291478130327832 3373 92208 A nucleotide analog. SGTC_755 1995-0008 37.3 µM -0.549518634424105 0.288115633212525 no 2394 0.291324790002903 3452 689533 SGTC_59 0330-0160 1.33 µM -0.549615793132204 0.288078270508581 no 2395 0.29129146209195 3449 4293482 SGTC_3092 9117248 49.47 µM -0.549884926515063 0.287974786313443 no 2396 0.291199151781659 3441 17141857 SGTC_1895 st058434 18.3 µM -0.550491517063678 0.287741611191314 no 2397 0.290991146820608 3490 5393175 SGTC_1342 1486-1464 234 µM -0.550702943465512 0.287660359254153 no 2398 0.290918663261403 3427 3253938 SGTC_42 0133-0086 60.653 µM -0.552048557276487 0.287143489244606 no 2399 0.290457542779349 3373 162923 Model of phenazepam hydroxylation. SGTC_2396 5342950 42.78 µM -0.553825579849233 0.286461583292801 no 2400 0.289849110140875 3401 1886677 SGTC_801 0866-0028 10.1 µM -0.554539356326896 0.286187898681281 no 2401 0.289604889470112 3440 6849771 SGTC_888 0916-0002 6.97 µM -0.554594813792373 0.286166639725043 no 2402 0.289585918584269 3498 2802138 YIL048W NEO1 SGTC_260 nsc-65238 3.989 µM -0.554761690693396 0.286102673985473 no 2403 0.289528836865415 3417 3246252 SGTC_2070 5230947 200 µM -0.554793671654751 0.286090416109242 no 2404 0.289517898098282 3496 2835538 SGTC_1161 k007-0610 110 µM -0.554939420359805 0.286034555733246 no 2405 0.289468048673133 3513 5843850 SGTC_2366 9070441 60.58 µM -0.555127076651035 0.285962641280358 no 2406 0.289403871822494 3375 6837235 SGTC_631 k072-0230 41.5 µM -0.55659436440528 0.285400637460808 no 2407 0.288902302541755 3453 5773147 SGTC_1862 st057513 3.81 µM -0.557006531534738 0.285242862971257 no 2408 0.288761483311403 3364 5393163 SGTC_377 3970-0964 33.1 µM -0.557942081562972 0.28488489573165 no 2409 0.2884419673397 3442 16481235 SGTC_220 paclitaxel 373.376 µM -0.559254675355584 0.284383022710127 no 2410 0.287993961711112 3446 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1619 st003326 88.7 µM -0.561685262811582 0.283454799516801 no 2411 0.287165238461157 3471 2849032 SGTC_2507 purpurin 79.67 µM -0.562135410453356 0.283283051008221 no 2412 0.287011881931523 3333 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_3227 9130768 49.47 µM -0.56308669286699 0.282920264722835 no 2413 0.286687926215771 3452 17720899 SGTC_2788 5282734 71.43 µM -0.563196133379814 0.282878542201196 no 2414 0.286650667776357 3500 743706 SGTC_2050 5263056 171 µM -0.563263508017577 0.282852858120609 no 2415 0.286627731581964 3469 763468 YGL055W OLE1 SGTC_1995 st072814 61.1 µM -0.564698219340779 0.28230619370299 no 2416 0.286139522802825 3367 5769371 SGTC_2044 5102272 200 µM -0.566267972271942 0.281708657716306 no 2417 0.285605814549054 3466 592666 SGTC_1672 st016598 6.51 µM -0.566290873305693 0.281699944813261 no 2418 0.285598031817891 3393 4665860 YNL267W PIK1 SGTC_3005 9076496 71.4286 µM -0.566902989592432 0.281467107857401 no 2419 0.28539004645837 3472 21368410 SGTC_2486 5283202 22.39 µM -0.568292814859929 0.280938790771713 no 2420 0.284918078530277 3395 1377751 SGTC_970 1315-0089 19.5 µM -0.569226765002388 0.280584035880535 no 2421 0.28460112960274 3442 6811083 YLR033W RSC58 SGTC_482 fipronil 114 µM -0.569529042932125 0.28046926402254 no 2422 0.284498583471648 3495 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2937 9044753 11.33 µM -0.569659986805233 0.280419553020023 no 2423 0.284454166959637 3454 6465530 YGL099W LSG1 SGTC_3355 9151058 44.0485 µM -0.570347562861496 0.280158594455967 no 2424 0.284220993706592 3482 17015728 SGTC_3351 9150312 21.596 µM -0.571764166083298 0.279621316477445 no 2425 0.283740878447632 3438 4904905 SGTC_861 0443-0273 110 µM -0.571844687126117 0.279590792126693 no 2426 0.283713599919778 3458 6149169 SGTC_3311 9131146 2.8755 µM -0.571880902133953 0.279577064073782 no 2427 0.283701331584776 3425 4900406 YPR165W RHO1 SGTC_2909 7941780 10.49 µM -0.573389418759143 0.279005520325313 no 2428 0.283190526555943 3515 1243215 SGTC_682 0kpi-0099 17 µM -0.573828197468678 0.278839383480407 no 2429 0.283042032766339 3478 1714895 YML126C ERG13 SGTC_1038 k292-0204 154 µM -0.574030517597582 0.27876279427922 no 2430 0.282973575120068 3430 4454212 SGTC_1474 0330-0125 5.35 µM -0.574164364617699 0.27871213151202 no 2431 0.282928290609805 3489 X1474 SGTC_3252 9135871 49.47 µM -0.574735308871661 0.278496072343691 no 2432 0.282735161925201 3506 17682838 SGTC_3123 9126162 49.47 µM -0.575399482173972 0.278244835754916 no 2433 0.28251057713676 3469 25239884 SGTC_2231 micatex 6.853 µM -0.575404024542693 0.278243117895319 no 2434 0.282509041467174 3471 20737 An antifungal of unknown mechanism. SGTC_3279 9140807 49.47 µM -0.575521279592475 0.278198775483798 no 2435 0.282469401641593 3487 45595718 SGTC_1573 oleylamine 1.06 µM -0.575933733720238 0.278042824847996 no 2436 0.282329986602737 3494 5356789 An amine of the fatty acid oleic acid. SGTC_90 0870-0863 4.608 µM -0.578996828059397 0.276885992448772 no 2437 0.281295656722957 3461 1738164 SGTC_2265 7929201 200 µM -0.579570410700101 0.276669630992784 no 2438 0.281102175837019 3426 1265108 SGTC_393 acivicin 6.25 µM -0.580607728777151 0.276278554137172 no 2439 0.280752431066304 3401 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_832 4083-0019 164 µM -0.58067359336071 0.276253731845558 no 2440 0.28073023110495 3531 1990758 SGTC_3268 9137683 49.47 µM -0.580947226431517 0.276150619859193 no 2441 0.280638010909158 3458 1953228 SGTC_623 k072-0108 16.9 µM -0.580960528995419 0.276145607592172 no 2442 0.280633528034281 3454 5382803 SGTC_386 1509-0011 3.07 µM -0.581000955063596 0.276130375746338 no 2443 0.280619904932879 3509 3107280 SGTC_1244 0416-0015 52.5 µM -0.581122285668987 0.276084662941678 no 2444 0.280579019891539 3438 96201 SGTC_589 1227-0070 34.1 µM -0.582657101204258 0.275506723203894 no 2445 0.28006207872277 3514 2841384 SGTC_1000 4048-0884 8.67 µM -0.58384976922694 0.275058031465008 no 2446 0.279660695252546 3498 13040088 SGTC_3281 9140613 49.47 µM -0.584977176160586 0.274634222692764 no 2447 0.279281531792865 3434 16013766 SGTC_2517 totarol 10 µM -0.586213906059859 0.274169688560132 no 2448 0.278865888944821 3449 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1833 st055984 71 µM -0.586326097437407 0.274127567020083 no 2449 0.278828198321314 3432 676288 SGTC_210 3551-0445 56.827 µM -0.587019471373505 0.273867315134805 no 2450 0.278595314800088 3542 2865180 YOR207C RET1 SGTC_170 4197-0004 226 µM -0.58733122819111 0.27375033974479 no 2451 0.278490635910326 3510 218692 SGTC_886 0866-0150 153 µM -0.587711894428417 0.273607542121857 no 2452 0.278362845226347 3558 271463 SGTC_469 w7 172 µM -0.587910769699393 0.273532953592079 no 2453 0.278296093628561 3508 45115570 A P450 inhibitor. SGTC_2289 7946404 165.07 µM -0.588198834618471 0.273424932172712 no 2454 0.278199419762545 3482 1246120 YPR165W RHO1 SGTC_2266 7929956 200 µM -0.589550066344217 0.272918516065941 no 2455 0.277746168469353 3519 2967153 SGTC_3254 9136651 49.47 µM -0.589848027674496 0.272806908414841 no 2456 0.277646270166677 3451 16454030 SGTC_2264 7948757 110.76 µM -0.591820810228705 0.272068533129397 no 2457 0.276985293198629 3452 2971411 SGTC_1366 1683-0113 21.9 µM -0.591895130043088 0.272040736059384 no 2458 0.276960407553529 3481 708623 SGTC_3333 9141820 12.094 µM -0.592042870265812 0.271985482509229 no 2459 0.276910940676371 3433 1939433 SGTC_2607 solasodine 47.35 µM -0.593122423146082 0.271581908657264 no 2460 0.276549612517289 3464 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_518 1021-0119 62.6 µM -0.59465451640557 0.27100967207665 no 2461 0.276037215438481 3424 1097762 SGTC_569 4130-2812 160 µM -0.59690156527883 0.270171489141938 no 2462 0.275286551086927 3450 743552 SGTC_2853 9015042 58.44 µM -0.597069385882653 0.270108941611156 no 2463 0.275230528149069 3437 6457456 SGTC_3056 9094900 49.47 µM -0.598676525056885 0.269510320350735 no 2464 0.274694307181423 3437 25236784 SGTC_3122 9126309 49.47 µM -0.598889062447462 0.269431205016119 no 2465 0.274623432804054 3541 17591206 SGTC_681 1642-0006 26.6 µM -0.598936210279994 0.269413656192481 no 2466 0.274607711742209 3525 4446530 SGTC_3288 9119690 36.221 µM -0.602016862729705 0.268268254569607 no 2467 0.273581456399962 3469 17595618 YKL019W RAM2 SGTC_1080 nisoldipine 24.4 µM -0.602837796860896 0.267963441173813 no 2468 0.273308299875292 3463 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1685 st024049 53.0905 µM -0.604571895613027 0.267320142936983 no 2469 0.272731742578163 3510 1941139 SGTC_1999 st074831 12.5 µM -0.604717715357835 0.267266083755049 no 2470 0.272683287602489 3438 17112523 SGTC_2656 pseudo-anisatin 100 µM -0.604868712832399 0.267210110868187 no 2471 0.272633116602906 3522 6708809 A neurotoxin. SGTC_2307 7538926 6.34 µM -0.606748658770903 0.266513734010732 no 2472 0.27200886244425 3487 96582 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.607177092923976 0.266355160298105 no 2473 0.271866696278697 3516 6312947 SGTC_2284 7945075 39.21 µM -0.608018560344925 0.266043852139195 no 2474 0.271587582031504 3549 1245402 SGTC_2191 5911152 200 µM -0.608118803008622 0.266006778786042 no 2475 0.271554341113431 3483 2875902 SGTC_3017 9080681 49.47 µM -0.608483590503657 0.265871889304003 no 2476 0.271433393044756 3508 16451914 SGTC_593 1203-0218 61.7 µM -0.608909096718704 0.265714591335616 no 2477 0.271292347140845 3564 3666956 SGTC_992 3909-8734 162 µM -0.610087199726781 0.265279325291061 no 2478 0.270902022721549 3494 4288319 SGTC_2340 7987427 183.45 µM -0.611388344588585 0.2647990207809 no 2479 0.270471258483817 3514 2239331 SGTC_1231 0242-0792 125 µM -0.613697782728892 0.263947605104585 no 2480 0.26970752692077 3525 3707635 SGTC_3194 9111903 49.47 µM -0.621518207174361 0.261074865076217 no 2481 0.267129359349733 3576 17087251 SGTC_2427 5545055 42.75 µM -0.621712672276587 0.261003635979782 no 2482 0.267065408724024 3549 5372858 SGTC_3152 9099253 49.47 µM -0.622812151553721 0.260601104376126 no 2483 0.266703986039892 3567 25236131 SGTC_2105 5350118 200 µM -0.622834357502032 0.260592977824835 no 2484 0.266696689011042 3555 2133313 SGTC_523 1934-0222 13.7 µM -0.6230026276918 0.260531401433042 no 2485 0.266641397538016 3556 1361595 SGTC_2736 butenafine 14.65 µM -0.623077117310285 0.260504145272179 no 2486 0.266616923034771 3525 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_751 0833-0568 350 µM -0.623917785057744 0.260196642145272 no 2487 0.266340789815862 3551 6954252 SGTC_876 0720-0963 56.8 µM -0.625130830991236 0.259753258855007 no 2488 0.265942597179302 3588 765861 SGTC_2053 5265679 138 µM -0.625859868220989 0.259486974435677 no 2489 0.265703429704614 3526 764595 SGTC_1680 diphenhydramine 100 µM -0.626196272878639 0.259364148540415 no 2490 0.265593105795746 3483 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1323 1348-1351 11.2 µM -0.626452591143947 0.25927058343734 no 2491 0.265509061817344 3498 6989654 SGTC_2832 7992762 51.95 µM -0.627043487918803 0.259054951990152 no 2492 0.265315364592011 3409 2985177 SGTC_1741 st038134 10.228 µM -0.627114583478456 0.259029013882186 no 2493 0.265292064150931 3629 1272587 SGTC_1074 carmofur 3.8 µM -0.627960236737314 0.258720593487448 no 2494 0.265014994405161 3605 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2644 guaiazulene 100 µM -0.6308853245663 0.257655244848835 no 2495 0.26405775404559 3566 3515 A coloring agent. SGTC_1867 st057372 64 µM -0.632897358233993 0.256923764853533 no 2496 0.263400336535445 3567 688837 SGTC_2775 cyproheptadine 69.59 µM -0.633438278073754 0.256727296514206 no 2497 0.263223737502201 3604 2913 A selective serotonin reuptake inhibitor. SGTC_19 0279-0214 38.434 µM -0.634096694682644 0.256488257578202 no 2498 0.26300885986909 3615 3566274 YBR002C RER2 SGTC_2852 9023854 51.95 µM -0.634390748950341 0.256381538293715 no 2499 0.262912922722923 3620 19798528 SGTC_34 0469-0683 81.75 µM -0.635347893287269 0.256034328169897 no 2500 0.262600772012026 3546 3690923 SGTC_1979 st071809 45.3 µM -0.635448171218753 0.255997965920562 no 2501 0.262568079639895 3619 4976333 SGTC_3280 9140961 49.47 µM -0.63572230305813 0.255898575444671 no 2502 0.262478718463051 3530 4901226 SGTC_1484 3473-2379 286 µM -0.636479162152124 0.255624269783744 no 2503 0.262232079277772 3678 671917 SGTC_3241 9133421 49.47 µM -0.639056553538111 0.254691308449133 no 2504 0.261393071096149 3581 17018221 SGTC_119 0121-0043 24.815 µM -0.639902508038831 0.254385479887437 no 2505 0.261117991639136 3653 1092378 SGTC_1047 2043-3044 82 µM -0.640425093343861 0.254196651629056 no 2506 0.260948136687368 3553 669592 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.641286895204993 0.253885413251572 no 2507 0.260668150959317 3588 616764 SGTC_160 3453-0671 289.699 µM -0.641396849797403 0.253845717717109 no 2508 0.260632439584795 3535 5322268 SGTC_648 0375-0473 33.3 µM -0.64234426094205 0.253503820712131 no 2509 0.260324840982505 3584 1713139 SGTC_1810 st050138 53 µM -0.643413028724937 0.2531184197558 no 2510 0.259978065820456 3590 3444541 SGTC_1575 cyproterone acetate 48 µM -0.643653361890833 0.253031797339382 no 2511 0.259900119520259 3516 9880 An androgen receptor antagonist and liver toxin. SGTC_2849 9019321 12.99 µM -0.644538146140663 0.252713032194862 no 2512 0.259613264880057 3556 16489627 SGTC_1015 4130-4525 82 µM -0.644876997171486 0.252591008858207 no 2513 0.259503449772498 3511 1363237 SGTC_1408 3909-7976 48.8 µM -0.645588740271407 0.252334804798476 no 2514 0.25927286564858 3604 24152374 SGTC_995 3931-2021 34.6 µM -0.646000805576872 0.252186537508874 no 2515 0.259139416851273 3564 730143 SGTC_1440 4100-1550 40 µM -0.646440930915999 0.252028224557376 no 2516 0.258996919942761 3595 742806 SGTC_408 cantharidin 100 µM -0.647706466302959 0.251573304182712 no 2517 0.258587410572714 3552 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2013 4024628 200 µM -0.649206410333438 0.251034683539024 no 2518 0.258102484423514 3612 5230760 SGTC_1844 rapamycin 4 nM -0.650485872099952 0.250575719381699 no 2519 0.257689212330316 3583 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_407 eburnamonine 100 µM -0.651198304987293 0.250320350704398 no 2520 0.257459242194321 3506 3195 SGTC_2818 7996756 12.99 µM -0.651354849623489 0.250264256410283 no 2521 0.257408724580664 3585 2241621 SGTC_295 k015-0027 31 µM -0.652183660533303 0.249967381519654 no 2522 0.257141349651037 3568 3887424 SGTC_1443 4112-3303 14 µM -0.654441966761769 0.249159419640808 no 2523 0.256413552126694 3595 704433 SGTC_145 3737-0113 38.366 µM -0.654514381598515 0.249133534543009 no 2524 0.256390232348914 3634 6849351 SGTC_2000 st075254 36.4 µM -0.655736439023329 0.248696918963584 no 2525 0.255996859490684 3587 17234175 SGTC_2922 7999257 32.47 µM -0.655797211943056 0.248675216710924 no 2526 0.255977305279041 3594 2988377 SGTC_2232 chlorophetanol 41.5365 µM -0.65648787869405 0.248428647735462 no 2527 0.255755132053597 3650 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2561 acetosyringone 100 µM -0.657729108671854 0.2479858546331 no 2528 0.255356107190433 3590 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2189 6047310 154.431 µM -0.65790961014617 0.247921498106215 no 2529 0.255298107524143 3564 711535 SGTC_2712 st079126 47.7 µM -0.658840378783415 0.247589780655487 no 2530 0.254999137484613 3587 3152970 SGTC_1057 3448-5381 134 µM -0.658841627633481 0.247589335736045 no 2531 0.254998736467464 3624 5497911 SGTC_396 dithiazanine 1.25 µM -0.660446276590554 0.247018011209882 no 2532 0.254483741758002 3580 10578 An antihelmenthic. SGTC_2134 5324836 1.464 µM -0.662170118938643 0.24640503544576 no 2533 0.253931101018807 3572 699272 SGTC_806 3966-4455 5.86 µM -0.663038883085807 0.246096423516218 no 2534 0.253652825758718 3538 714982 SGTC_2408 sulbentine 18.36 µM -0.663987234988032 0.245759776379134 no 2535 0.253349240559222 3570 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_823 0417-1665 178 µM -0.664089459183798 0.245723503474391 no 2536 0.253316528087538 3629 3429856 SGTC_36 0335-0881 14.2 µM -0.664332498632682 0.245637275681047 no 2537 0.253238762646926 3577 23828853 SGTC_989 1501-0895 10.3 µM -0.664917791716561 0.245429686671616 no 2538 0.253051537687226 3609 2830112 SGTC_510 ag-490 170 µM -0.664925833239752 0.245426835198499 no 2539 0.25304896585268 3718 5328779 SGTC_901 1112-0062 60.1 µM -0.665115767697239 0.24535949082086 no 2540 0.252988225140447 3623 1908457 SGTC_1454 4239-0054 42.6 µM -0.666745777874788 0.244781952552088 no 2541 0.252467266295719 3712 1340767 SGTC_1197 1601-0112 267 µM -0.668820665711126 0.244047847060347 no 2542 0.251804941192294 3623 7350313 SGTC_1298 1079-1278 263 µM -0.670789151119354 0.243352486480132 no 2543 0.251177429836435 3657 2840950 SGTC_2312 7706453 155.7 µM -0.671078592186945 0.24325033280167 no 2544 0.251085231964907 3656 976098 SGTC_1883 5-benzylidenerhodanine 20 µM -0.67279260030816 0.242645875898251 no 2545 0.250539623012801 3619 1273210 SGTC_742 0kpi-0133 140 µM -0.673575114450367 0.24237018746553 no 2546 0.250290739443165 3639 2728852 SGTC_2534 helenine 20.12 µM -0.674569818308547 0.2420199873696 no 2547 0.249974556916701 3642 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_125 0133-0007 11.75 µM -0.674621699727389 0.242001729287526 no 2548 0.249958071396117 3706 26541 SGTC_2022 5136654 200 µM -0.675020796039385 0.241861304499785 no 2549 0.249831276298859 3627 1713771 SGTC_1653 st012112 65 µM -0.675334930309775 0.241750805294281 no 2550 0.249731498131215 3643 720429 SGTC_2211 7117706 200 µM -0.675372470979516 0.241737601900895 no 2551 0.249719575539926 3590 822771 SGTC_2596 sinensetin 100 µM -0.675905458610558 0.241550187557685 no 2552 0.249550335904345 3622 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2809 7964133 12.99 µM -0.676608679091954 0.241303035043161 no 2553 0.24932713548351 3645 1253665 SGTC_1202 1988-0068 29.6 µM -0.676637881212971 0.24129277469449 no 2554 0.249317869099034 3580 2850480 SGTC_771 0250-0039 27.3 µM -0.678302827652763 0.240708177565378 no 2555 0.248789853093192 3627 3005115 SGTC_1663 st014140 55.4 µM -0.681642956470671 0.239537717277811 no 2556 0.247732372770496 3709 4207120 SGTC_1682 st012968 530 nM -0.681820042946037 0.239475748836351 no 2557 0.247676374504724 3611 24207270 SGTC_2367 9070478 135.38 µM -0.682057472192875 0.239392678192243 no 2558 0.247601305263644 3627 572802 SGTC_2589 lobaric acid 100 µM -0.682452206028896 0.23925460538747 no 2559 0.247476527116761 3639 73157 A novel microtubule depolymerizer. SGTC_747 3448-8087 38.7 µM -0.683147212923128 0.239011606720124 no 2560 0.247256912229559 3659 5168703 SGTC_1217 1183-1422 255 µM -0.683280338253291 0.238965076860935 no 2561 0.247214857916481 3676 2849664 SGTC_1936 st074407 74.3 µM -0.683709645399725 0.238815059515057 no 2562 0.247079265780094 3687 809813 SGTC_3131 9127911 49.47 µM -0.686627433458183 0.237796832047429 no 2563 0.246158768165853 3690 45595681 SGTC_452 diindolylmethane 8 µM -0.686832307674793 0.237725426177595 no 2564 0.246094204053402 3618 3071 Inhibits expression of several cancer promoting factors. SGTC_3094 9117742 49.47 µM -0.686990072328586 0.237670447664511 no 2565 0.246044492251666 3613 17149698 SGTC_3290 9121031 71.43 µM -0.687112838269809 0.237627670481843 no 2566 0.246005812306963 3636 17014854 SGTC_637 1181-0519 7.26 µM -0.68765059349079 0.237440342137251 no 2567 0.245836419871589 3669 6252091 YGR060W ERG25 SGTC_950 1165-0508 94.1 µM -0.68799548547718 0.237320240856133 no 2568 0.245727812152575 3642 6148369 SGTC_3026 9090633 49.47 µM -0.689103301859507 0.236934693191731 no 2569 0.245379131161049 3650 25236842 SGTC_3151 9099821 49.47 µM -0.692263817202262 0.235836649963918 no 2570 0.244385834138313 3620 17174189 SGTC_2179 6298986 200 µM -0.692279619616445 0.235831166861812 no 2571 0.244380873154227 3618 738374 SGTC_1419 3993-2473 62.6 µM -0.693467586693951 0.235419168811273 no 2572 0.244008080153318 3714 704026 SGTC_200 k038-0079 37.545 µM -0.695347857532585 0.234767886065704 no 2573 0.243418664600909 3626 3436683 SGTC_1137 ixabepilone 100 µM -0.695349201978951 0.234767420736918 no 2574 0.243418243427662 3684 154225 A novel microtubule stabilizer. SGTC_361 000s-0510 1.45 µM -0.696103365860169 0.234506476078492 no 2575 0.243182049400324 3670 660 SGTC_3204 9114183 49.47 µM -0.696633381876862 0.23432318380508 no 2576 0.243016129651445 3686 17027248 SGTC_2623 humulene 100 µM -0.697996715088143 0.233852074917552 no 2577 0.242589624195409 3618 6187145 An anti-inflammatory. SGTC_1112 tnp00069 1.16933 µM -0.698623971211042 0.233635498801176 no 2578 0.242393529489211 3719 145826 SGTC_1406 3909-7906 11.9 µM -0.699941111938912 0.233181084648044 no 2579 0.241982040630763 3679 X1406 SGTC_740 k014-0057 261 µM -0.700853038342467 0.232866757269785 no 2580 0.241697367188507 3694 4012779 SGTC_252 miconazole 1.30953 nM -0.700935689619642 0.232838280250795 no 2581 0.241671575164713 3636 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1914 st062367 72.6 µM -0.701663451055235 0.232587617802373 no 2582 0.241444535620014 3682 978205 SGTC_1675 st018485 24.5 µM -0.701955804055292 0.2324869650829 no 2583 0.241353362960622 3719 3323024 SGTC_2240 6690706 185.951 µM -0.702215860826995 0.232397451826811 no 2584 0.24127227786494 3613 805876 SGTC_3115 9123671 49.47 µM -0.70241118557379 0.232330232369054 no 2585 0.241211385800278 3758 3286988 SGTC_1931 st074438 57.1 µM -0.70300295372271 0.232126646109273 no 2586 0.241026954366019 3650 2787313 SGTC_2705 st078069 42.8 µM -0.70430400012519 0.231679395880026 no 2587 0.240621737875796 3671 1530061 SGTC_1874 staurosporine 7.6 µM -0.704403093040663 0.231645351198812 no 2588 0.240590890167648 3705 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_3134 9127454 49.47 µM -0.707310599704164 0.23064768077213 no 2589 0.239686739944628 3762 24262820 SGTC_463 ikarugamyin 104 µM -0.707868852953541 0.230456399044498 no 2590 0.239513351822657 3736 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1260 0700-1617 7.75 µM -0.707978062841604 0.230418989382881 no 2591 0.239479440286209 3703 2853078 SGTC_563 tetrahydrosecaminediol 614 µM -0.708024517711207 0.230403077375469 no 2592 0.239465016050195 3724 334274 A psychoactive constituent of the cannabis plant. SGTC_476 mead acid 10 µM -0.708608141448782 0.23020322333442 no 2593 0.239283841317688 3704 5312531 An omega 9 fatty acid. SGTC_2846 9008642 19.48 µM -0.709239822866985 0.229987021907675 no 2594 0.239087832423989 3690 2992898 SGTC_1146 3579-1023 7 µM -0.709435685305669 0.229920008452322 no 2595 0.239027074712595 3743 X1146 SGTC_3200 9114385 49.47 µM -0.709647277061877 0.229847625565023 no 2596 0.238961447157889 3673 17018030 YLR208W SEC13 SGTC_1699 st031318 29.054 µM -0.710055797865009 0.229707911819865 no 2597 0.23883476773077 3755 5340658 SGTC_1632 st005650 90 µM -0.71015492425695 0.229674017855652 no 2598 0.238804034872726 3706 2759605 SGTC_1476 4112-3294 3.34 µM -0.710188426656767 0.229662563122627 no 2599 0.238793648375332 3725 704369 SGTC_1547 harmine 94.2 µM -0.711113087050235 0.229346540810741 no 2600 0.238507080411821 3724 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_311 1315-0136 58 µM -0.711681682915229 0.229152332208801 no 2601 0.238330956416229 3729 6759207 SGTC_754 3474-0146 171 µM -0.712631070313319 0.228828266787919 no 2602 0.238037040117563 3650 24762078 SGTC_1840 st055363 71 µM -0.712722157112415 0.228797188603482 no 2603 0.238008851440439 3674 676033 SGTC_137 0438-0332 85.389 µM -0.713292320703717 0.228602706582307 no 2604 0.237832444211925 3725 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2727 riluzole 51.77 µM -0.713297508204093 0.228600937559335 no 2605 0.237830839541156 3695 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1220 1838-0075 193 µM -0.714531026200556 0.228180505965598 no 2606 0.237449438977559 3658 5529645 SGTC_2386 9075165 157.42 µM -0.714644657782838 0.228141797720403 no 2607 0.237414321285342 3678 16452277 SGTC_1348 1493-0373 93.8 µM -0.715231963941268 0.227941792571458 no 2608 0.237232860546737 3689 3010129 SGTC_919 tnp00227 403.569 nM -0.715867347313662 0.227725526014116 no 2609 0.237036631151932 3709 1269246 A methoxyflavone. YNL221C POP1 SGTC_340 k038-0059 454 µM -0.718138723006771 0.226953359018463 no 2610 0.236335878029943 3701 23733424 SGTC_100 0086-0128 49.5915 µM -0.718441636283384 0.226850493647865 no 2611 0.236242511061794 3685 93297 SGTC_893 0958-0369 48.9 µM -0.720190965935521 0.226256959055943 no 2612 0.235703712717084 3730 6819948 SGTC_3301 9125354 19.7965 µM -0.721331981861977 0.225870294031608 no 2613 0.23535264216804 3686 41905162 SGTC_2236 dapsone 200 µM -0.72187801374986 0.225685388200373 no 2614 0.235184739920333 3725 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2652 actinonin 100 µM -0.721941552179367 0.225663877390601 no 2615 0.235165206448247 3692 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1714 st033236 13.627 µM -0.723373106720518 0.22517953502767 no 2616 0.234725344535669 3727 2916566 SGTC_2256 7954252 200 µM -0.723944452962135 0.224986394187324 no 2617 0.234549918790487 3668 2972920 SGTC_1513 0337-0559 19 µM -0.724329751023884 0.224856199060274 no 2618 0.234431658101817 3684 775073 SGTC_988 1497-1057 103 µM -0.724635762151389 0.224752826027877 no 2619 0.234337756701559 3710 3533044 SGTC_3320 9137005 35.139 µM -0.729006792455272 0.22327920149129 no 2620 0.232998753770781 3742 4908713 SGTC_2528 xanthyletin 44.79 µM -0.730212274070718 0.222873761747312 no 2621 0.23263022055333 3779 65188 An natural product with antifungal activity of unknown mechanism. SGTC_610 4215-0184 155 µM -0.731192520561899 0.222544384785354 no 2622 0.232330784012001 3761 5605015 SGTC_925 2064-1272 59.6 µM -0.731217499201558 0.222535995230056 no 2623 0.232323156573082 3719 6815817 SGTC_1987 st072290 61.9 µM -0.731921913166712 0.222299478550028 no 2624 0.232108115178677 3728 54697379 SGTC_1147 3809-1045 12.3 µM -0.733491369534646 0.221773028044546 no 2625 0.231629394887284 3700 325925 SGTC_144 4161-2749 112.381 µM -0.734131253579956 0.221558593131286 no 2626 0.231434373560799 3653 797501 YMR168C CEP3 SGTC_1018 4259-0013 28.1 µM -0.737910429420401 0.220294552939417 no 2627 0.230284440412524 3804 6801262 SGTC_1125 tnp00248 1.32998 µM -0.738782494880745 0.22000345699008 no 2628 0.230019541525813 3846 24207736 SGTC_3072 9116419 49.47 µM -0.739579708741889 0.219737539743571 no 2629 0.229777528855944 3743 17170162 SGTC_1917 st066507 28.5 µM -0.739800541538361 0.219663911796571 no 2630 0.229710515190303 3707 3156428 SGTC_2049 5262831 67.185 µM -0.739851188670343 0.219647027514238 no 2631 0.229695147413279 3778 763417 SGTC_2200 6600604 21.907 µM -0.740374296273351 0.219472682241912 no 2632 0.229536455414237 3705 2904777 SGTC_3187 9109394 49.47 µM -0.741955074554712 0.218946311838495 no 2633 0.22905727773701 3694 17098090 SGTC_317 4495-0002 170 µM -0.742047956395951 0.21891540647913 no 2634 0.229029140144242 3766 15991618 SGTC_2352 9027995 87.8 µM -0.742429243684968 0.218788563838685 no 2635 0.228913653426577 3716 2997347 SGTC_1608 st001473 40.5 µM -0.743008934320744 0.218595799511569 no 2636 0.228738135670401 3705 7292267 SGTC_582 0987-0078 156 µM -0.743471833693248 0.218441941978966 no 2637 0.228598034049756 3793 1625765 SGTC_2071 5230951 39.92 µM -0.744792186648654 0.218003428618495 no 2638 0.228198679515098 3780 1799272 SGTC_3000 9075062 71.4286 µM -0.745334167545674 0.217823573876434 no 2639 0.22803486534964 3719 17057871 SGTC_1135 dihydrocapsaicin 536.708 nM -0.746157936977171 0.217550372413896 no 2640 0.227786007078645 3684 107982 A Capsaicinoid. SGTC_1893 st059353 36.1 µM -0.747283545798528 0.217177386460667 no 2641 0.227446211277124 3771 3112488 SGTC_1873 rapamycin 2 nM -0.747288996796244 0.217175581096933 no 2642 0.227444566439385 3729 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1807 st050092 58.9 µM -0.749488360138875 0.216447862401268 no 2643 0.226781455849276 3758 5008496 SGTC_1025 k007-0731 70 µM -0.749829198104818 0.216335213387441 no 2644 0.226678790515319 3729 6256118 SGTC_78 0336-0123 156.75 µM -0.753549883852205 0.215107713312716 no 2645 0.225559773511362 3640 6765896 SGTC_3104 9120930 49.47 µM -0.758481028935753 0.213487114746482 no 2646 0.224081532940511 3789 17014836 SGTC_868 0527-0199 213 µM -0.758772677902308 0.213391489022651 no 2647 0.223994276181638 3734 2849450 SGTC_2068 5226020 147 µM -0.760390862192967 0.212861373313734 no 2648 0.223510491865606 3821 1810509 SGTC_1395 3486-0190 4.35 µM -0.762567603707984 0.212149488548889 no 2649 0.222860655625769 3771 6748079 SGTC_1187 1391-0724 117 µM -0.764099032062832 0.211649483142117 no 2650 0.222404114542103 3848 6997986 SGTC_3130 9127414 49.47 µM -0.765367630140663 0.211235813653065 no 2651 0.22202633129941 3784 1494646 SGTC_3161 9100388 49.47 µM -0.766393538015418 0.210901628260431 no 2652 0.221721088310265 3795 25236368 SGTC_1481 3346-2004 36 µM -0.769051758601754 0.210037167151016 no 2653 0.220931292425024 3801 2770522 SGTC_2801 7907800 81.82 µM -0.769305063841993 0.20995490033285 no 2654 0.220856115901411 3846 6620925 SGTC_3337 9144342 33.5465 µM -0.770008740065586 0.209726464364561 no 2655 0.220647354093761 3794 17682949 SGTC_629 3448-6466 76.7 µM -0.771001237847577 0.209404516160309 no 2656 0.220353098940586 3788 573744 SGTC_121 0557-0495 61.343 µM -0.77121596948423 0.209334899412955 no 2657 0.220289465045272 3914 3104427 SGTC_3029 9088683 49.47 µM -0.771614570168654 0.209205707792293 no 2658 0.220171371055642 3779 25236615 SGTC_1631 benzylvanillin 81.9 µM -0.771658002104558 0.209191633778291 no 2659 0.220158505608411 3850 75506 SGTC_2060 5238662 140 µM -0.772560565430795 0.208899286481274 no 2660 0.219891245082438 3780 790130 SGTC_985 1493-0307 8.71 µM -0.772739707781845 0.20884128951754 no 2661 0.219838220899226 3771 3278274 SGTC_652 0437-0092 114 µM -0.773165122306205 0.208703600470598 no 2662 0.219712332248629 3753 3091274 SGTC_2706 st078239 82.5 µM -0.773442712299926 0.208613784949825 no 2663 0.219630210147858 3785 15434492 SGTC_562 3772-2733 112 µM -0.773711446097716 0.208526856602704 no 2664 0.219550724855147 3822 2876874 YIL048W NEO1 SGTC_2942 9052777 62.25 µM -0.774949610376204 0.20812661886342 no 2665 0.219184717767322 3875 6469503 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.775076950685167 0.208085481718981 no 2666 0.219147095286163 3851 5282309 SGTC_1375 2910-0797 186 µM -0.77567586407025 0.207892067795122 no 2667 0.21897019713271 3801 742508 SGTC_2324 6149169 200 µM -0.778872629127327 0.206861496970087 no 2668 0.218027374356491 3738 2888231 SGTC_1333 1482-0047 286 µM -0.783191525043297 0.205473987380411 no 2669 0.216757325454084 3763 3811116 SGTC_1731 st035964 63 µM -0.783886488886506 0.205251237207452 no 2670 0.216553359193401 3806 6739575 SGTC_2700 st077718 96.8 µM -0.785349228888881 0.204782868036711 no 2671 0.216124419853492 3807 904970 SGTC_1725 st036284 20.55 µM -0.786201251687086 0.204510343650159 no 2672 0.215874796455008 3891 707914 SGTC_2885 9057732 51.95 µM -0.786482021872678 0.204420584996125 no 2673 0.215792573759048 3829 6471414 SGTC_2011 4012611 177 µM -0.786753949770214 0.204333675466087 no 2674 0.215712957806125 3837 2049887 SGTC_2998 9066762 71.4286 µM -0.788573071844359 0.203752840900446 no 2675 0.215180787374532 3820 4945196 SGTC_678 1218-2179 85.9 µM -0.789325063883249 0.203513022264104 no 2676 0.214961020597561 3798 6820081 YOR116C RPO31 SGTC_2445 5742597 35.57 µM -0.791026590994159 0.202971008174532 no 2677 0.214464237290218 3776 1774255 SGTC_2450 5739737 12.93 µM -0.792118256484137 0.202623717294065 no 2678 0.214145862976169 3848 2262825 SGTC_1030 k029-0042 36.7 µM -0.79438230289051 0.201904590645982 no 2679 0.213486451772546 3828 6080581 SGTC_1352 1496-0991 99 µM -0.797404670899921 0.200946984025107 no 2680 0.212608023709435 3820 3000039 SGTC_122 0236-0016 402.397 µM -0.79920062217547 0.200379248006696 no 2681 0.21208704562347 3846 6808838 SGTC_2857 9024691 58.44 µM -0.801115976596784 0.199774829294115 no 2682 0.211532253927531 3914 16478292 SGTC_3036 9090181 49.47 µM -0.801692419905169 0.199593138914338 no 2683 0.211365450820898 3845 25236586 SGTC_1235 benzylparaben 21.5 µM -0.802537257122753 0.199327032635573 no 2684 0.211121122886594 3834 7180 SGTC_3222 9128301 49.47 µM -0.802870298235905 0.199222190296311 no 2685 0.211024852502544 3867 4911358 SGTC_2424 5537928 59.2 µM -0.805564925754091 0.198375135615493 no 2686 0.21024687808771 3891 5382802 SGTC_2067 5224629 34.075 µM -0.805587329115052 0.198368102253159 no 2687 0.210240417010796 3827 2835000 SGTC_3185 9108267 49.47 µM -0.80692591947837 0.19794813528571 no 2688 0.209854582349102 3806 4910486 SGTC_2016 5121758 140 µM -0.807108534398024 0.197890883663176 no 2689 0.20980197779291 3807 2795203 SGTC_1428 4049-0204 61.7 µM -0.80858388383578 0.197428713660623 no 2690 0.209377268960398 3896 X1428 SGTC_540 1187-0821 17.3 µM -0.808783580078438 0.197366206732098 no 2691 0.209319821304421 3803 847520 SGTC_1633 st005664 67.9 µM -0.809138091580611 0.197255270561657 no 2692 0.20921785999319 3855 2063822 SGTC_2457 5731572 11.68 µM -0.809199234604096 0.197236141082134 no 2693 0.209200277560321 3923 2865357 SGTC_174 3553-0389 74.3 µM -0.809430029888269 0.197163943552519 no 2694 0.209133917360204 3847 738071 SGTC_753 1322-0200 289 µM -0.812391089526327 0.196239082269043 no 2695 0.208283628741844 3884 5403907 SGTC_897 1000-0139 31.4 µM -0.813833602635937 0.195789480258299 no 2696 0.207870141078127 3821 6151020 SGTC_776 4476-4378 112 µM -0.8144155235382 0.195608284454948 no 2697 0.207703474281143 3921 2892008 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.814475535050376 0.195589604144609 no 2698 0.207686290995953 3887 115019 SGTC_1459 k035-0031 35.7 µM -0.815044642326223 0.19541250697414 no 2699 0.207523378469121 3697 3877128 YMR208W ERG12 SGTC_2972 9093619 59.92 µM -0.815776460803887 0.195184919863838 no 2700 0.207313999307791 3849 25236256 SGTC_2565 isoliquiritigenin 100 µM -0.815862173768892 0.195158274662094 no 2701 0.207289484312446 3939 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_3247 9135149 49.47 µM -0.816704288230458 0.194896607920664 no 2702 0.207048720060886 3835 8934436 YOR116C RPO31 SGTC_1055 3448-0672 86 µM -0.817845672919804 0.194542290927716 no 2703 0.206722657360313 3900 748378 SGTC_2198 6589944 200 µM -0.81843490545515 0.19435953057596 no 2704 0.206554448638804 3853 5290268 SGTC_473 2-arachidonoylglycerol 10 µM -0.818613137055913 0.194304269654505 no 2705 0.206503584684177 3730 5282280 An endocannabinoid. SGTC_351 caspofungin 25 nM -0.819527302120083 0.194020982090168 no 2706 0.206242815779204 3874 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2001 4023502 57.655 µM -0.820487268814308 0.193723772246708 no 2707 0.205969192006516 3888 108941 YCR052W RSC6 SGTC_3172 9105863 49.47 µM -0.820940145469455 0.193583656091514 no 2708 0.205840181251459 3851 2348785 SGTC_1647 st011722 22.4 µM -0.822156631121041 0.193207591958867 no 2709 0.20549387900552 3821 2854783 SGTC_1603 st002045 67.8 µM -0.822189091834104 0.19319756317256 no 2710 0.205484643014779 3865 5887985 SGTC_3113 9123498 49.47 µM -0.822379330192496 0.193138795132632 no 2711 0.205430519778039 3905 8897275 SGTC_3346 9158254 43.5805 µM -0.822467841226891 0.19311145620741 no 2712 0.205405341077607 3875 17639500 SGTC_3120 9124077 49.47 µM -0.825001785675046 0.192329784160458 no 2713 0.204685288454205 3926 18774327 YGL155W CDC43 SGTC_2012 4023501 200 µM -0.826061890583239 0.192003337553004 no 2714 0.204384492182861 3898 3477460 SGTC_462 ag-879 158 µM -0.826134579424128 0.191980966324824 no 2715 0.204363876951332 3911 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1372 2752-0194 270 µM -0.826760096698045 0.191788518674487 no 2716 0.204186525599066 3830 823334 SGTC_686 1319-0111 510 µM -0.827769136467714 0.191478324936905 no 2717 0.203900628339214 3885 4562600 SGTC_1515 3460-0031 42.1 µM -0.82822185507166 0.191339252500027 no 2718 0.203772434441614 3816 2876596 SGTC_1643 st009866 20.2 µM -0.829676883918691 0.19089269575927 no 2719 0.203360747209313 3844 3156273 YOR207C RET1 SGTC_1191 1487-1166 10.6 µM -0.829809136055242 0.190852138538633 no 2720 0.203323352285763 3926 3955771 SGTC_2187 6125751 200 µM -0.829981849141276 0.190799181285379 no 2721 0.203274523014325 3866 874498 SGTC_1152 3909-8331 15.9 µM -0.830610749114193 0.190606424299978 no 2722 0.203096780188294 3839 16001939 SGTC_262 fenpropimorph 62.5 µM -0.834032777636841 0.189559673496543 no 2723 0.202131256778864 3842 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2400 5203494 178.7 µM -0.834235949255752 0.18949763755799 no 2724 0.202074018525878 3810 6777674 SGTC_204 PMA1.184 62.41 µM -0.835663020850782 0.189062251044587 no 2725 0.201672252092717 3908 2252213 YGL008C PMA1 SGTC_2895 9054447 58.44 µM -0.838149795375328 0.188305032568286 no 2726 0.200973289657737 3919 2697450 SGTC_688 0527-0193 473 µM -0.838772219370502 0.188115798709103 no 2727 0.200798571428728 3904 4007154 SGTC_3276 9139060 49.47 µM -0.839605468933613 0.187862651937079 no 2728 0.200564815929726 3960 4870619 SGTC_82 0054-0107 293.755 µM -0.839694189424748 0.187835710457612 no 2729 0.200539936373586 3858 3104697 SGTC_2274 7947094 46.08 µM -0.84113210167164 0.187399396824009 no 2730 0.200136966491091 3849 2971028 SGTC_448 monastrol 171 µM -0.841769901970605 0.187206066296208 no 2731 0.199958381113815 3802 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_517 1365-0151 113 µM -0.843291510736309 0.186745333406072 no 2732 0.199532714732989 3974 768657 SGTC_550 4123-0385 25.7 µM -0.844783423759902 0.186294274303018 no 2733 0.199115885634953 3900 5731123 SGTC_642 0335-0876 158 µM -0.845613488612146 0.186043608287859 no 2734 0.198884199155421 3923 6812350 SGTC_2138 5575593 77.673 µM -0.848473068000998 0.185181664073203 no 2735 0.19808728254894 3868 762213 SGTC_1048 3161-0300 24.5 µM -0.850550619875191 0.184556999443629 no 2736 0.197509514940565 3891 2165101 SGTC_2142 5622915 118.518 µM -0.850861397277824 0.18446366974177 no 2737 0.197423175369865 3916 5322196 SGTC_95 0471-0001 561.058 µM -0.853124542727178 0.183784909132971 no 2738 0.196795121266757 3888 4015405 SGTC_1064 honokiol 6.76 µM -0.853666468229101 0.183622606478925 no 2739 0.196644909201995 3906 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1145 3546-0597 10.2 µM -0.858974508641025 0.182037612952803 no 2740 0.195177290004834 3888 875334 SGTC_3322 9139058 2.11 µM -0.859269631704249 0.181949740245818 no 2741 0.195095887297431 4016 4908926 YPR165W RHO1 SGTC_854 0422-0053 192 µM -0.859800985019612 0.18179159701501 no 2742 0.194949378105819 3946 3596728 SGTC_332 4112-0506 40.9 µM -0.859981177149157 0.181737987133041 no 2743 0.194899709214954 3891 2790355 SGTC_2030 5175110 200 µM -0.861087158665506 0.181409157613978 no 2744 0.194595020576916 3977 2831986 SGTC_1704 st028805 70.8 µM -0.861349871258074 0.181331102903609 no 2745 0.194522688085059 3952 2876101 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.861727216970539 0.181219026273656 no 2746 0.194418822365144 3943 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2629 bisabolol 100 µM -0.863044760435319 0.180828038879784 no 2747 0.194056428762336 3949 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2137 5261020 140 µM -0.863250770041326 0.180766952370923 no 2748 0.193999802536446 3882 763655 SGTC_1393 3470-5649 58.2 µM -0.866792429947423 0.179718793779955 no 2749 0.193027875294927 3898 4108395 SGTC_2776 terbinafine 19.92 µM -0.867620062887379 0.179474406314565 no 2750 0.192801179758117 3947 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2355 9061122 103.12 µM -0.867816264049572 0.179416501730483 no 2751 0.192747462489186 3953 5302957 SGTC_2117 5521686 200 µM -0.869468203370648 0.17892943295868 no 2752 0.19229554618425 3882 803312 SGTC_355 1311-2252 105 µM -0.870741518544226 0.178554568711053 no 2753 0.191947651651476 3939 5338538 SGTC_2337 9009472 200 µM -0.870893617550739 0.178509823826812 no 2754 0.191906121009503 3881 5742383 SGTC_3033 9090887 49.47 µM -0.871002116279667 0.178477909702886 no 2755 0.191876498787257 3957 19325384 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.873646868857742 0.177701086502074 no 2756 0.191155296845579 3935 364106 SGTC_1930 st074634 34.3 µM -0.879149586048866 0.17609166379891 no 2757 0.18966008746246 3871 684253 YOR116C RPO31 SGTC_1778 st046819 58.9 µM -0.88037563093681 0.175734333802379 no 2758 0.189327926705929 4000 671715 SGTC_3278 9139605 49.47 µM -0.881219676050275 0.175488604564063 no 2759 0.189099465789397 3989 7958859 SGTC_2646 retinol 96.75 µM -0.8815392514854 0.175395622533191 no 2760 0.189013009415742 3951 445354 A vitamin A analog and teratogen. SGTC_534 k292-0788 63.4 µM -0.883286122799555 0.174887913932101 no 2761 0.188540849841338 3935 4146317 SGTC_721 1187-1332 279 µM -0.883988836136808 0.174683941483601 no 2762 0.188351119671743 3887 25730 SGTC_1189 1431-2119 7.28 µM -0.886791344777565 0.173871976965166 no 2763 0.187595624169673 3962 3107275 SGTC_949 1165-0505 146 µM -0.888261338615882 0.173447040195513 no 2764 0.187200095437527 3980 6244267 SGTC_1071 trifluoperazine 6.31 µM -0.888348793702084 0.173421780068242 no 2765 0.18717658031132 4060 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_867 0518-0118 155 µM -0.888616723784354 0.173344406945563 no 2766 0.18710455002173 3941 6848158 SGTC_811 0416-0114 265 µM -0.888922112189914 0.173256243375283 no 2767 0.187022470352292 4029 6612453 SGTC_2707 st078556 66.6 µM -0.889043318153384 0.173221259948513 no 2768 0.186989899831513 3919 17250899 SGTC_2344 7990960 76.95 µM -0.8930320284966 0.172072517083614 no 2769 0.185920010495367 3942 140813 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.89361785735365 0.171904209677812 no 2770 0.185763194293442 3974 23665772 A membrane-active detergent. SGTC_2592 piperlongumine 83.33 µM -0.894728995874867 0.171585270775184 no 2771 0.185465987294704 3986 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.894815248404702 0.171560528850933 no 2772 0.185442928845125 3941 688761 SGTC_1124 fisetin 1.16336 µM -0.896502554031939 0.171076976226272 no 2773 0.184992208422443 3993 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2466 5983409 37.09 µM -0.900596735567333 0.169907282423431 no 2774 0.183901385454023 3987 2879657 SGTC_2873 9040596 71.43 µM -0.903054356845151 0.169207616938095 no 2775 0.183248523331178 3971 6463863 SGTC_2061 5245884 80.95 µM -0.904802227744807 0.168711139073286 no 2776 0.182785085631979 3952 573863 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.90609559800992 0.16834436416997 no 2777 0.182442627541598 3971 75037 A free radical scavenger. SGTC_3286 9117135 37.221 µM -0.906300199759862 0.168286390067768 no 2778 0.182388489908937 3951 3438150 SGTC_20 0481-0013 4.944 µM -0.909695151321265 0.167326302121662 no 2779 0.181491650992707 3998 182045 SGTC_2145 5634607 200 µM -0.910729406531027 0.167034518972442 no 2780 0.181218982947045 3945 308662 SGTC_2270 7924575 90.91 µM -0.911825671580635 0.166725600092841 no 2781 0.180930247068962 3997 1262135 SGTC_713 1488-1073 324 µM -0.911885667075211 0.166708704480122 no 2782 0.180914453693858 3925 3312542 SGTC_2936 9038235 15.59 µM -0.912233063375702 0.166610894299075 no 2783 0.180823021145161 3930 4749415 SGTC_3143 9086658 49.47 µM -0.912894641871994 0.166424727891323 no 2784 0.180648977916005 4058 25236626 SGTC_1648 st011736 69.8 µM -0.913201707884371 0.166338365994724 no 2785 0.180568232941105 3975 2855514 SGTC_1478 0453-0656 35.7 µM -0.913219784308806 0.166333282927163 no 2786 0.180563480335076 3982 5258496 SGTC_1782 st039423 80.636 µM -0.913987057668013 0.166117619126412 no 2787 0.180361823181536 4015 2068169 SGTC_400 oxethazaine 37.5 µM -0.916033962635849 0.165543163036639 no 2788 0.179824540974848 4007 4621 A local anesthetic. SGTC_2095 5432005 200 µM -0.9193393714798 0.164618228711385 no 2789 0.17895904525025 4005 783734 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.919494723985706 0.164574839826276 no 2790 0.178918431999796 4015 2374 Ca(2+)-ATPase inhibitor. SGTC_957 1187-1561 14.1 µM -0.920133791746582 0.164396430558747 no 2791 0.178751423815245 3954 1538454 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.920387709482526 0.164325578876167 no 2792 0.178685094505166 4008 229346 A bile salt which induces apoptosis. SGTC_380 3970-0968 6 µM -0.921542735988079 0.164003537107232 no 2793 0.178383569919049 3895 2891601 SGTC_1294 1000-1494 117 µM -0.923621204872227 0.163425055416937 no 2794 0.177841784789894 3985 712797 YDL207W GLE1 SGTC_1746 st038117 42 µM -0.923922650199144 0.163341267010166 no 2795 0.177763294663223 4070 2898218 SGTC_3216 9129716 49.47 µM -0.925684356039663 0.162852149308626 no 2796 0.177305020078427 3971 8056934 SGTC_2377 9073351 62.6 µM -0.927051554158155 0.162473219272238 no 2797 0.176949883864439 3967 7337946 YHR072W ERG7 SGTC_2007 4011539 71.82 µM -0.927928552462952 0.162230454402471 no 2798 0.176722316199554 3982 45595301 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.92831948292454 0.16212231575739 no 2799 0.176620935364856 4044 6708760 SGTC_1174 0739-0097 51.1 µM -0.929089751413592 0.161909382546299 no 2800 0.176421287633254 4038 728447 SGTC_1076 itraconazole 331 nM -0.929143801862731 0.161894447671048 no 2801 0.176407283530673 4000 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_3058 9093861 49.47 µM -0.929366174490408 0.161833012527947 no 2802 0.176349675698839 4008 17217477 SGTC_1266 0828-0227 32.9 µM -0.929604599013914 0.161767159586132 no 2803 0.17628792268871 4023 3913820 SGTC_3154 9100113 49.47 µM -0.930848416836316 0.161423899860114 no 2804 0.175965990284836 4035 25237525 SGTC_3350 9150499 3.57 µM -0.932864861945925 0.160868426061472 no 2805 0.175444873360429 3976 4910996 YPR165W RHO1 SGTC_1272 0839-0021 27 µM -0.934026466703285 0.160549003830139 no 2806 0.175145120362579 4025 5027250 SGTC_3037 9091026 49.47 µM -0.935013197447824 0.160277994756166 no 2807 0.17489074906434 3975 25236398 YIL048W NEO1 SGTC_338 4055-0136 114 µM -0.937197688347221 0.15967908095545 no 2808 0.174328439331302 3955 2900563 SGTC_2956 9076196 2.52 µM -0.937427451960098 0.159616172739057 no 2809 0.174269362722864 4029 16423868 SGTC_1090 efavirenz 20.7 µM -0.938751823918814 0.159253882042783 no 2810 0.173929089460973 4046 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2150 5556613 200 µM -0.939583798078459 0.159026565653118 no 2811 0.173715545064512 4008 743190 SGTC_3112 9123419 49.47 µM -0.940206315680916 0.158856617209036 no 2812 0.173555871419913 4053 17015854 SGTC_2984 9022109 38.96 µM -0.94100293090364 0.158639313489484 no 2813 0.173351678605681 4042 6459207 SGTC_1684 st024538 14.6195 µM -0.941195336828292 0.158586857509352 no 2814 0.173302382996792 4010 6732859 SGTC_765 1319-0117 244 µM -0.94219857493422 0.158313527161129 no 2815 0.173045491697049 3974 3487746 YGL099W LSG1 SGTC_2867 9039098 71.43 µM -0.944762915777525 0.157616282878891 no 2816 0.17238996421891 3986 6463460 SGTC_2018 5133068 143 µM -0.946022640038381 0.157274503975239 no 2817 0.172068519415966 3999 785362 SGTC_783 0848-0141 92.7 µM -0.946212209590457 0.157223113602269 no 2818 0.172020179948322 3967 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1265 0819-1001 68.8 µM -0.946584181677327 0.157122307853028 no 2819 0.171925353770357 3986 3106768 SGTC_1066 ketoconazole 628 nM -0.950062690630456 0.156181677402483 no 2820 0.171040199660338 4100 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2961 9083290 32.55 µM -0.951851181567565 0.15569949522345 no 2821 0.170586230440396 3960 17741490 SGTC_2661 dactinomycin 12.96 µM -0.951944280949222 0.1556744222794 no 2822 0.170562620345654 4010 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2154 5570129 200 µM -0.952435959011957 0.15554205078288 no 2823 0.170437965010286 4060 673366 SGTC_693 4161-2696 114 µM -0.954236233249608 0.155058007728717 no 2824 0.169982038841922 4068 805759 SGTC_1512 0259-0544 12.2 µM -0.954946309374021 0.15486736206785 no 2825 0.169802424609279 3997 18476 SGTC_1651 st011928 86.1 µM -0.955035631814121 0.154843391190848 no 2826 0.169779839058968 4053 720198 SGTC_841 0251-0215 91.2 µM -0.955231252535438 0.154790902303782 no 2827 0.169730382276356 4056 3888614 SGTC_192 3455-0609 60.9 µM -0.956674706222242 0.154403958697352 no 2828 0.169365734342048 4103 3769639 SGTC_2268 7933382 153.85 µM -0.957978669988948 0.154054958120238 no 2829 0.169036757215943 4051 935025 YOR257W CDC31 SGTC_2380 9035439 200 µM -0.957992876369617 0.154051158716643 no 2830 0.169033175348478 4156 6462575 SGTC_1245 0418-0076 17.2 µM -0.95975938968175 0.153579199403545 no 2831 0.168588162684683 4105 6790114 SGTC_2511 berberine 10.47 µM -0.96045682369179 0.153393129890438 no 2832 0.168412675577492 4019 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_233 rapamycin 362 pM -0.960695524972074 0.15332948071784 no 2833 0.168352640977043 4033 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_460 trequinsin 123 µM -0.961144599444161 0.153209783426229 no 2834 0.168239733745779 4095 5537 A vasodilator. SGTC_2110 5483698 200 µM -0.961509959756899 0.153112445184461 no 2835 0.168147910046906 4024 2848765 YHR062C RPP1 SGTC_2197 6588183 93.1375 µM -0.961804955182859 0.153033883267043 no 2836 0.168073794243213 4003 884136 SGTC_3223 9129970 49.47 µM -0.963960434863895 0.152460656217927 no 2837 0.167532881229434 4074 17248386 SGTC_14 0354-0009 295 µM -0.964401996230621 0.15234340371574 no 2838 0.167422210901396 4123 1713507 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.964864805971627 0.152220573168789 no 2839 0.167306265580313 4041 3256 An antibiotic and ribosome inhibitor. SGTC_624 k048-0052 28 µM -0.966128521738012 0.151885515682574 no 2840 0.166989937077531 4034 6835531 SGTC_307 1501-1223 22.3 µM -0.966954054222571 0.1516669014708 no 2841 0.16678350136423 4078 2830329 SGTC_814 3342-0569 96 µM -0.967001478971893 0.151654348993773 no 2842 0.166771647158764 4097 4346283 SGTC_1865 st057639 52.2 µM -0.968766477147887 0.15118767681692 no 2843 0.166330857985033 4029 688818 SGTC_2091 4-phenylthiadiazole 200 µM -0.973559625440364 0.14992517489941 no 2844 0.165137620682979 4047 270010 SGTC_29 0299-0004 12.984 µM -0.974399388033727 0.149704709652356 no 2845 0.164929136609849 3947 16871 A napthoquinone isolated from Swertia calycina. SGTC_697 0508-1955 564 µM -0.97589507926866 0.149312577534032 no 2846 0.164558230431513 4067 6243113 SGTC_1042 0350-0096 82 µM -0.980208614219957 0.148185522422442 no 2847 0.163491576621505 4042 3122515 SGTC_2726 cimetidine 79.27 µM -0.981736914407763 0.147787572149955 no 2848 0.163114737226256 4048 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1286 0929-0070 131 µM -0.982051215023403 0.147705820994585 no 2849 0.163037308845327 4159 1420408 SGTC_1054 3429-0080 167 µM -0.983003727385873 0.147458252783636 no 2850 0.162802802080455 4123 1162877 SGTC_1159 4092-0538 61.2 µM -0.98334346320905 0.147370019093041 no 2851 0.162719212854777 4104 717301 SGTC_120 rhodamine 6G 52.259 µM -0.983909943484645 0.147222975695327 no 2852 0.162579897098826 4087 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_481 bay k-8644 50 µM -0.985093996345598 0.146915944396093 no 2853 0.16228895104698 4032 2303 A calcium channel antagonist. SGTC_1222 0366-0074 1.18 µM -0.987255169401091 0.146356648589203 no 2854 0.161758781029922 4086 286520 SGTC_2144 5628481 200 µM -0.990854976411188 0.145428222421235 no 2855 0.16087819995575 4056 2818399 SGTC_1462 k081-0014 26.5 µM -0.991910161242568 0.145156832128411 no 2856 0.160620675936783 3663 3270634 SGTC_2917 7979103 53.79 µM -0.992484544110259 0.145009245968475 no 2857 0.16048060767834 4138 2980565 SGTC_923 1900-2434 73.3 µM -0.993976639033705 0.144626328275373 no 2858 0.160117120377024 4029 5910570 SGTC_54 0159-0055 9 µM -0.994482206375946 0.144496738698867 no 2859 0.159994081959667 4105 3319099 SGTC_1239 0337-0584 35.4 µM -0.995500405045266 0.144235986390685 no 2860 0.159746473686988 4151 914301 YML130C ERO1 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.995627469072928 0.144203468614367 no 2861 0.159715591522858 4051 688803 SGTC_2370 9071495 200 µM -0.995638094874972 0.144200749520665 no 2862 0.159713009161212 4089 21791103 SGTC_2553 4-methylesculetin 85.09 µM -0.995881178083432 0.144138555089691 no 2863 0.159653940728613 4113 5319502 SGTC_1165 k072-0275 30.3 µM -0.996658404271542 0.14393981805944 no 2864 0.159465173222661 4054 6153523 YGL055W OLE1 SGTC_2571 chrysanthemic acid 100 µM -0.996773812839191 0.143910323812403 no 2865 0.159437156023968 4106 2743 An insecticide. SGTC_885 0865-0106 16.8 µM -0.997974995061487 0.143603587199573 no 2866 0.159145741961266 4026 2793380 SGTC_2882 9058044 58.44 µM -0.999020299981342 0.143337015106903 no 2867 0.158892428777982 4122 18076804 SGTC_209 4077-0173 175.592 µM -1.00137538082687 0.142737651093533 no 2868 0.15832268090089 4066 15993494 SGTC_1947 st076332 61.6 µM -1.00238240015127 0.142481884279247 no 2869 0.158079469532517 3990 24208416 SGTC_3325 9138760 55.175 µM -1.00317627383877 0.142280471685167 no 2870 0.157887909234267 4025 43844959 SGTC_2729 fluphenazine 10.66 µM -1.00457425466042 0.141926260420608 no 2871 0.157550949682533 4025 3372 An atypical antipsychotic. SGTC_158 k038-0087 26.446 µM -1.00556321535768 0.141676044885102 no 2872 0.157312863081561 4014 X158 SGTC_24 0417-1663 219 µM -1.00628228274981 0.141494302399292 no 2873 0.157139900330035 4112 4329390 SGTC_1822 st052468 42 µM -1.00880079089335 0.140859001805108 no 2874 0.156535090852511 4099 2873678 SGTC_2210 7115885 190.385 µM -1.01042730585099 0.140449738946657 no 2875 0.156145305524073 4168 2927039 SGTC_17 0960-0276 49.807 µM -1.01148126839606 0.140184972917514 no 2876 0.155893070982554 4080 6821114 SGTC_1471 k673-0312 37 µM -1.01369707587043 0.13962944597279 no 2877 0.155363659901713 4049 24099884 SGTC_1297 1068-0111 14.1 µM -1.01693359569224 0.138820708782438 no 2878 0.154592510009685 4075 767057 SGTC_636 0kpi-0074 126 µM -1.01791954494897 0.138574976292021 no 2879 0.154358096206158 4108 616434 SGTC_706 4262-0057 46.9 µM -1.02249664134848 0.137438089050403 no 2880 0.153272950739192 4107 883298 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.02324298957442 0.137253312114106 no 2881 0.153096485763218 4125 4620898 SGTC_1285 0929-0069 65.5 µM -1.02455014326123 0.136930102903744 no 2882 0.152787749722385 4135 1206237 SGTC_1439 4092-1168 46 µM -1.02490028616816 0.136843614326623 no 2883 0.152705119792607 4118 2886240 SGTC_3079 9117512 49.47 µM -1.02615907419265 0.13653299035806 no 2884 0.152408304344309 4160 7185044 SGTC_268 camptothecin 39.6153 µM -1.02664007803622 0.136414423209556 no 2885 0.152294987402969 4096 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2098 5376439 882.5 nM -1.03009038873078 0.135565988618898 no 2886 0.151483788296711 4163 2844116 SGTC_708 3448-5400 146 µM -1.03106859751453 0.135326105396722 no 2887 0.151254326270881 4068 3462195 SGTC_2499 avocadenofuran 51.48 µM -1.03639913999052 0.134024026218757 no 2888 0.150007985713969 4092 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1330 1469-0054 61.8 µM -1.0425202797153 0.132539479109274 no 2889 0.148585264113977 4130 7102664 SGTC_89 0302-0250 142.109 µM -1.04274388860369 0.132485463060125 no 2890 0.148533462612893 4228 4203518 YLR208W SEC13 SGTC_2959 9079155 11 µM -1.04437949136705 0.132090820181073 no 2891 0.148154924162366 4184 16189457 SGTC_371 0195-0006 7.36 µM -1.04483652022816 0.131980692004049 no 2892 0.148049266415514 3974 3928593 SGTC_930 2810-3379 265 µM -1.04530247455762 0.131868478306554 no 2893 0.147941597172379 4183 1015764 SGTC_385 1494-0393 12.4 µM -1.04642626542911 0.131598111615132 no 2894 0.147682135683301 4126 3090647 SGTC_1102 cgs 12066b 26.1 µM -1.04872150694033 0.131047101317152 no 2895 0.147153156375569 4140 6438352 A 5-HT1B full agonist. SGTC_2569 tetrandrine 100 µM -1.05031448195228 0.130665619859912 no 2896 0.146786774527299 4162 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_802 4112-3352 742 µM -1.05100371266189 0.130500802892246 no 2897 0.146628442342494 4202 704594 SGTC_2787 5284540 71.43 µM -1.05476662977548 0.129603505294887 no 2898 0.145766035009928 4199 736958 SGTC_849 0386-0493 241 µM -1.05688646419766 0.129099900087347 no 2899 0.145281703358881 4123 726119 SGTC_1624 st003710 6.25 µM -1.05925469421248 0.128538890431279 no 2900 0.144741901067547 4193 24207033 SGTC_2108 5365811 200 µM -1.0595752768021 0.12846307789234 no 2901 0.144668933041586 4162 780283 SGTC_2560 caryophyllene 100 µM -1.06198870817722 0.12789333720115 no 2902 0.144120405714296 4193 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_464 bw-b 70c 158 µM -1.06215251666078 0.127854730531123 no 2903 0.144083226032033 4181 5353454 SGTC_2931 9014674 55.67 µM -1.06245677924904 0.127783042885011 no 2904 0.144014184586063 4116 2996810 SGTC_2585 alliin 100 µM -1.06290878082157 0.127676597876592 no 2905 0.143911660292459 4224 87310 A garlic compound which reacts with lipids. SGTC_1198 1612-1005 86.7 µM -1.06343835236628 0.127551963805323 no 2906 0.14379160400135 4225 6998509 SGTC_1223 0764-0573 147 µM -1.06490644094703 0.127206893198815 no 2907 0.143459135014787 4135 1609797 SGTC_2778 tioconazole 65.09 nM -1.06595444921576 0.126960959088208 no 2908 0.143222116748479 4049 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_451 chloral hydrate 100 µM -1.06735313963009 0.126633246941032 no 2909 0.1429062002356 4179 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1311 1190-0148 100 µM -1.06879549914062 0.1262959206429 no 2910 0.142580913940119 4219 1961333 SGTC_2339 9000433 200 µM -1.06942674009033 0.126148488758185 no 2911 0.142438711764136 4185 2988954 SGTC_715 0868-0130 184 µM -1.07353650482932 0.125191550162175 no 2912 0.141515234479688 4220 2876258 SGTC_1442 4112-3290 3 µM -1.07405329996798 0.125071576685136 no 2913 0.141399396757142 4147 704353 SGTC_1131 3454-3128 32.3 µM -1.07723274885613 0.124335237517006 no 2914 0.140688149072508 4213 710982 SGTC_2815 7968870 71.43 µM -1.07747398818406 0.124279492100968 no 2915 0.140634282730543 4143 2977326 YHR190W ERG9 SGTC_2748 diazoxide 86.69 µM -1.08020835482101 0.123648858414289 no 2916 0.140024704378351 4229 3019 A potassium channel activatior. SGTC_2696 st077691 74.316 µM -1.08086891730274 0.123496847903424 no 2917 0.139877713385035 4235 757133 SGTC_136 0097-0015 404.482 µM -1.08141838289319 0.123370503085559 no 2918 0.139755524043068 4165 4861337 SGTC_2480 5767542 37.17 µM -1.08400687400896 0.122776520393396 no 2919 0.139180875513417 4123 2867358 SGTC_1707 st032323 6.317 µM -1.08421260690639 0.122729396923345 no 2920 0.139135271614497 4049 3132057 YMR211W DML1 SGTC_1097 itavastatin 7.23 µM -1.08433151253848 0.122702167171604 no 2921 0.139108918968481 4193 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1205 4161-2785 76 µM -1.08464034261299 0.122631463941534 no 2922 0.139040489893381 4240 3498106 SGTC_890 0929-0006 47.2 µM -1.08568686964663 0.122392085690867 no 2923 0.138808775900267 4145 1378169 SGTC_2691 st077356 60.2 µM -1.086417642277 0.122225126362022 no 2924 0.138647129846503 4228 2839272 SGTC_1992 st073643 23.3 µM -1.0871650957636 0.1220545214398 no 2925 0.138481926716249 4151 3161292 SGTC_3140 9094243 49.47 µM -1.08930106692943 0.121567911839836 no 2926 0.138010571217847 4164 19291112 SGTC_1397 3532-0190 20.1 µM -1.09112612699417 0.121153214558547 no 2927 0.13760869391424 4130 5322280 SGTC_580 1123-0028 41 µM -1.0913491449688 0.121102607849451 no 2928 0.137559640291075 4223 1677248 YPR107C YTH1 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.09371617543536 0.12056640327088 no 2929 0.137039738887022 4160 16623 A steroid. SGTC_3210 9128157 49.47 µM -1.09454806662368 0.120378352147788 no 2930 0.136857339161588 4204 17590849 SGTC_62 0180-0423 3.232 µM -1.09597261521782 0.120056809299908 no 2931 0.136545379420985 4148 30102 YGL099W LSG1 SGTC_2881 9058953 51.95 µM -1.09879061180277 0.119422527650922 no 2932 0.135929704060677 4137 17122249 SGTC_447 ml7 120 µM -1.09898968053205 0.119377810349761 no 2933 0.135886283554206 4219 4216 Selective myosin light chain kinase inhibitor. SGTC_1713 st033146 12.748 µM -1.1010778501122 0.11890945157404 no 2934 0.135431388144026 4194 674619 SGTC_1518 st038567 90.8 µM -1.10191906407239 0.118721141569435 no 2935 0.135248429875344 4134 77966 SGTC_1252 0493-0875 34.8 µM -1.10390886302623 0.118276553819753 no 2936 0.134816336901899 4181 3960963 SGTC_2992 9074591 71.4286 µM -1.1041684185348 0.118218647326825 no 2937 0.13476004327145 4159 17741321 SGTC_1516 st013856 110 µM -1.10815074098441 0.117332708873481 no 2938 0.133898360175692 4252 5281404 A mutagen and neurotoxin. SGTC_3233 9132340 49.47 µM -1.11107452337373 0.116685261880799 no 2939 0.133268136467794 4200 17682950 SGTC_2072 5231554 129 µM -1.111259682271 0.116644345460478 no 2940 0.13322829414785 4229 789545 SGTC_331 k048-0133 24.5 µM -1.11137427349802 0.116619028183785 no 2941 0.133203640620133 4166 6813582 SGTC_3023 9089636 49.47 µM -1.11428069778452 0.115978198098662 no 2942 0.132579392522703 4274 17249241 SGTC_1466 k213-0079 57.5 µM -1.11583982917068 0.115635461287217 no 2943 0.1322453507887 4137 3657981 SGTC_1287 0971-0001 34.6 µM -1.11709796173483 0.115359416712225 no 2944 0.131976220960895 4198 4665869 SGTC_1771 st048882 4.1505 µM -1.1173307891723 0.11530838386606 no 2945 0.131926457795759 4237 4580403 SGTC_520 3584-0023 682 µM -1.11892312373891 0.114959794283103 no 2946 0.131586468529568 4212 1340790 SGTC_1785 bathophenanthroline 24 µM -1.12129738824991 0.114441419730902 no 2947 0.131080648454723 4132 72812 An iron chelator. SGTC_283 0987-0079 11.7 µM -1.12167186082492 0.114359813076362 no 2948 0.131000992550868 4209 411556 SGTC_92 0063-0024 660.874 µM -1.12178017332404 0.114336216883329 no 2949 0.130977959103391 4302 3594437 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.12186940266686 0.114316780615815 no 2950 0.130958985931412 4153 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2695 st077686 51.995 µM -1.12232297862268 0.114218017387555 no 2951 0.130862569727097 4227 2876092 SGTC_1689 st020265 53.493 µM -1.12312975298499 0.114042497690094 no 2952 0.13069119573507 4222 5758320 YPR016C TIF6 SGTC_1926 methyl fluorone black 53.6 µM -1.12755740844543 0.113082649356492 no 2953 0.129753441337373 3895 72721 Reacts with homocysteine. SGTC_2332 7982454 138.89 µM -1.12946421059964 0.112671064571522 no 2954 0.129351029499022 4158 2981748 SGTC_1519 esterone 74 µM -1.13069844792617 0.112405224431889 no 2955 0.129091017419943 4181 698 A steroid. SGTC_3055 9094636 49.47 µM -1.1313276938406 0.112269864902685 no 2956 0.128958596143423 4254 25236176 SGTC_2106 5357045 167.29 µM -1.13293004409292 0.11192570322146 no 2957 0.128621815992237 4239 668842 SGTC_719 2810-4230 27.3 µM -1.13313596939406 0.111881528208196 no 2958 0.128578579145851 4225 721079 SGTC_2414 st077232 92.9 µM -1.13345273332224 0.111813600480242 no 2959 0.128512089900205 4166 729801 SGTC_1818 st052136 56.3 µM -1.13384805046202 0.111728868967934 no 2960 0.128429145692005 3917 674169 SGTC_147 4466-0538 29.23 µM -1.13867893600289 0.110697134752702 no 2961 0.127418545726764 4334 6742687 YHR072W ERG7 SGTC_1337 1486-1011 40.3 µM -1.14233773498202 0.109920280015007 no 2962 0.126656830911347 4198 X1337 SGTC_2963 9082507 9 µM -1.14270820276983 0.109841839086176 no 2963 0.126579881470036 4266 16459611 SGTC_1326 1431-2094 10.8 µM -1.14293741003684 0.10979332804964 no 2964 0.126532289398913 4223 616278 SGTC_1864 st057645 30.4 µM -1.14437730498343 0.109488930289228 no 2965 0.126233598022665 4277 688666 SGTC_917 harmaline 728.087 nM -1.14780527055786 0.108766689069043 no 2966 0.125524480523814 4187 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_993 3909-8757 62.7 µM -1.14885302472797 0.10854662188895 no 2967 0.125308295240618 4182 4288324 YLR208W SEC13 SGTC_948 3448-0295 75.3 µM -1.14959805593395 0.108390332718969 no 2968 0.125154729629813 4214 678569 SGTC_2782 7736369 71.43 µM -1.14989452719017 0.108328185420715 no 2969 0.125093657631363 4258 2950836 YOL077C BRX1 SGTC_2854 9024559 71.43 µM -1.15254148507661 0.107774457498306 no 2970 0.12454931635026 4271 3163529 SGTC_2449 5812982 45.77 µM -1.15353017189172 0.107568153961238 no 2971 0.12434642040097 4173 776185 SGTC_315 k915-0449 187 µM -1.153856779727 0.107500065171658 no 2972 0.12427944554125 4250 20970215 YNL149C PGA2 SGTC_3118 9124250 49.47 µM -1.15537871882124 0.107183192139746 no 2973 0.123967686387632 4185 1504786 SGTC_3099 9120367 49.47 µM -1.15867823477099 0.106498535517046 no 2974 0.123293682939257 4302 24824940 SGTC_1438 4092-1045 4 µM -1.1608606807147 0.106047411648346 no 2975 0.122849280539799 4274 1351342 SGTC_2612 dictamnine 15.46 µM -1.16209672521562 0.10579252753715 no 2976 0.122598088752134 4186 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_966 1300-0360 30.2 µM -1.16650534818432 0.104887034547986 no 2977 0.121705093762255 4245 70588 SGTC_91 0417-1751 58.384 µM -1.16668428717466 0.104850400893226 no 2978 0.121668945291512 4359 6795624 SGTC_1722 st034304 3.6505 µM -1.16997818159722 0.104177705687995 no 2979 0.121004874635172 4218 4036148 YLR033W RSC58 SGTC_1665 st014639 11.4 µM -1.17181991183732 0.103802945008828 no 2980 0.120634683302593 4314 981133 YIL048W NEO1 SGTC_194 1486-1323 56.904 µM -1.17282655823262 0.103598523441628 no 2981 0.120432682780245 4346 5178754 SGTC_3234 9132280 49.47 µM -1.17378960443226 0.103403229418321 no 2982 0.120239654455236 4286 17612295 SGTC_2510 benzyl isothiocyanate 8.31 µM -1.17405620286619 0.103349213767126 no 2983 0.120186257297986 4260 2346 DNA damaging agent; causes G2/M arrest. SGTC_2401 5128683 200 µM -1.17515864268302 0.103126065339006 no 2984 0.119965626390133 4276 708373 SGTC_2957 9076800 11.52 µM -1.1760572009392 0.102944444235882 no 2985 0.119786009529905 4233 16459615 SGTC_1696 st025591 34.7925 µM -1.17768536080801 0.102615944599558 no 2986 0.119461032583816 4274 2787147 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.17788782039715 0.102575149418087 no 2987 0.119420665643224 4208 5711223 A potent inhibitor of glutathione S-transferases. SGTC_157 1348-1695 65.819 µM -1.17798341987595 0.102555890422543 no 2988 0.119401608106106 4205 5380510 SGTC_2111 5486399 200 µM -1.18166961030678 0.10181529247509 no 2989 0.118668410547605 4216 689674 SGTC_2300 7976697 71.57 µM -1.18509476033094 0.101130636841363 no 2990 0.117989991258936 4173 2236109 SGTC_2292 7671323 168.05 µM -1.18708833854024 0.100733687148884 no 2991 0.117596388824367 4322 937504 SGTC_1695 st026914 34.495 µM -1.18815270021392 0.100522223502736 no 2992 0.117386627408871 4262 3289191 SGTC_796 1234-0020 70.7 µM -1.18835970708402 0.100481133750168 no 2993 0.117345861871737 4214 46495034 SGTC_2502 avocadyne acetate 18.59 µM -1.19056904130933 0.100043355912359 no 2994 0.116911405601385 4218 3952079 SGTC_1863 st057641 20.1 µM -1.19272294542108 0.0996179038130475 no 2995 0.116488948121843 4293 3921635 SGTC_1734 st037168 69.4 µM -1.19281094587532 0.0996005495887331 no 2996 0.116471711144015 4295 708907 SGTC_175 3793-3120 23.7 µM -1.19591663772084 0.0989895023264565 no 2997 0.115864545896306 4279 5322297 SGTC_1767 st044992 70.3 µM -1.19660285513663 0.0988548592097399 no 2998 0.115730693550567 4319 9600693 SGTC_2202 7226349 200 µM -1.19689589213235 0.0987974030987134 no 2999 0.115673567753451 4247 844334 SGTC_3003 9075612 71.4286 µM -1.19856618777823 0.0984703728201352 no 3000 0.115348336129204 4303 6501993 SGTC_2461 5755302 26.15 µM -1.19998154915346 0.0981938775485885 no 3001 0.115073253158474 4315 2788904 SGTC_412 gemfibrozil 100 µM -1.20352345163835 0.0975044490573909 no 3002 0.114386910881196 4219 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1801 st050089 28.441 µM -1.20437981596172 0.0973382926590634 no 3003 0.114221404854495 4336 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2552 juarezic acid 87.02 µM -1.20543116640618 0.0971345881830974 no 3004 0.114018447958675 4233 1549512 SGTC_2904 7225135 42.03 µM -1.20971843829182 0.0963071464618206 no 3005 0.113193476119311 4377 4446116 SGTC_44 0929-0055 61.211 µM -1.21120145218219 0.096022134710162 no 3006 0.112909103170014 4183 1379590 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.21728843029981 0.0948588102140191 no 3007 0.111747247357561 4344 6708784 An antioxidant flavonoid SGTC_1316 1272-0050 65.9 µM -1.21851613062069 0.0946254396825025 no 3008 0.111513949369461 4258 7340392 SGTC_2039 Aminomethylbenzodioxan 200 µM -1.21916354818918 0.0945025442326683 no 3009 0.11139106206932 4287 15053 SGTC_2062 5245942 200 µM -1.22166048136623 0.0940296682478986 no 3010 0.110918023285912 4344 1376160 SGTC_301 4119-0100 24.5 µM -1.22238390552856 0.0938929909708315 no 3011 0.110781241332506 4327 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_544 k015-0020 52.4 µM -1.22368968487876 0.093646660011096 no 3012 0.110534656188525 4319 3008304 SGTC_1690 st023502 41.2 µM -1.22373474905396 0.0936381673296651 no 3013 0.110526153237681 4310 24207482 SGTC_684 1140-0066 328 µM -1.22385952670363 0.0936146550141429 no 3014 0.110502611966519 4350 6813534 SGTC_3007 9078383 71.4286 µM -1.22412537470607 0.0935645748279318 no 3015 0.11045246753686 4290 6496995 SGTC_1062 mesoridazine 14.2 µM -1.22594256235281 0.0932227845174596 no 3016 0.110110145213371 4347 4078 A neuroleptic. SGTC_817 1391-0715 46 µM -1.22788053414759 0.0928592937635323 no 3017 0.10974590892139 4288 1353946 SGTC_1300 1094-0077 113 µM -1.22906309509822 0.0926380051610751 no 3018 0.109524075297333 4273 5532636 SGTC_1666 st014829 29 µM -1.22928216793581 0.0925970536656758 no 3019 0.109483015353034 4300 3858230 SGTC_66 0109-0187 42.4 µM -1.23317817771712 0.0918710040356535 no 3020 0.108754647583027 4181 759417 SGTC_2734 clemastine 41.6 µM -1.23360480326146 0.091791756133 no 3021 0.108675101153571 4365 26987 Clemastine is a selective histamine H1 antagonist. SGTC_141 0443-0274 32.331 µM -1.23427250371605 0.091667828979156 no 3022 0.108550689130028 4283 1627241 SGTC_1905 st060207 84.5 µM -1.23429410242701 0.0916638222662261 no 3023 0.108546666373119 4300 1948547 SGTC_1549 4'-methoxyflavonol 74.6 µM -1.23571367398566 0.0914007661908985 no 3024 0.108282506474928 4240 97141 SGTC_1629 st005085 44.9 µM -1.23657473277912 0.0912414791470815 no 3025 0.108122502601398 4255 24207091 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.23905792102101 0.0907832676069902 no 3026 0.107662024376465 4296 442882 SGTC_1730 st033808 45.1 µM -1.23934737958927 0.0907299664442195 no 3027 0.107608439759156 4253 1045166 SGTC_1613 st002381 52.1 µM -1.23982815832961 0.0906414867406715 no 3028 0.107519480391841 4304 551167 SGTC_2168 5727979 200 µM -1.24113051409706 0.0904021305540847 no 3029 0.107278769391449 4237 695210 SGTC_10 0279-0212 42.575 µM -1.24184730636657 0.0902705937906909 no 3030 0.107146452439157 4302 39851 YBR002C RER2 SGTC_2267 7931562 200 µM -1.24375403533164 0.0899213867740131 no 3031 0.106795051002292 4256 934880 SGTC_1545 lovastatin 49.4 µM -1.24515960127468 0.0896646085542441 no 3032 0.106536544607234 4364 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1016 4226-1401 38 µM -1.24559078401923 0.0895859465745351 no 3033 0.106457333717394 4312 2901613 SGTC_286 k060-0067 22.9 µM -1.24997382643671 0.0887892449411005 no 3034 0.105654554322454 4360 5985051 SGTC_1349 flufenamic acid 69 µM -1.25192177035197 0.0884368671607116 no 3035 0.105299185547919 4264 3371 A non-steroidal anti-inflammatory. SGTC_1328 1441-0025 69.2 µM -1.25426346251973 0.0880146418837903 no 3036 0.104873129826136 4311 4562601 SGTC_1313 1220-0047 237 µM -1.25434936521442 0.0879991815917383 no 3037 0.104857524155109 4318 3528706 SGTC_1199 1638-0010 4.46 µM -1.2568768168341 0.0875452106251344 no 3038 0.104399122254201 4299 3111136 SGTC_638 3970-0837 4.09 µM -1.2585459709894 0.0872463633458214 no 3039 0.104097186324241 4312 4118451 YLR208W SEC13 SGTC_3006 9075424 71.4286 µM -1.26680428527283 0.0857789844507705 no 3040 0.102612639731449 4297 7465181 SGTC_1120 ficusin 1.78878 µM -1.26694363030876 0.0857543843911886 no 3041 0.102587723242651 4365 6199 A DNA cross-linker. SGTC_744 1594-0068 283 µM -1.26829749701616 0.0855156467803506 no 3042 0.102345865292375 4316 668392 SGTC_363 0455-0021 3.06 µM -1.26904713771045 0.0853836712168825 no 3043 0.102212126207491 4296 4597466 SGTC_2185 6113692 200 µM -1.26967827994209 0.0852726758619924 no 3044 0.102099626358704 4336 874150 SGTC_2868 9035608 32.47 µM -1.2696878398099 0.0852709954545158 no 3045 0.102097923024154 4326 6462614 SGTC_2993 9054257 71.4286 µM -1.27067179619089 0.0850981709455314 no 3046 0.10192271662997 4259 6470217 YGL055W OLE1 SGTC_2283 7944793 200 µM -1.27815295450968 0.083792738181986 no 3047 0.100597750222224 4359 2970533 SGTC_2243 6634756 200 µM -1.28139462041088 0.0832317740650678 no 3048 0.100027546379214 4400 885676 SGTC_601 0986-0029 62.9 µM -1.28667907376931 0.0823233696752645 no 3049 0.0991030849126923 4297 24747981 SGTC_2725 haloperidol 53.21 µM -1.29032675357605 0.0817006978248287 no 3050 0.0984686158492253 4309 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_166 k072-0058 166.424 µM -1.29148944035689 0.0815029711593669 no 3051 0.0982670071989926 4251 5846229 SGTC_3002 9075603 71.4286 µM -1.29577121407032 0.0807779230357661 no 3052 0.0975271591016422 4304 20105405 SGTC_208 k072-0098 12.366 µM -1.29721732994116 0.0805341504451427 no 3053 0.0972782097773287 4343 5948901 SGTC_263 alizarin 107.927 µM -1.30438448538114 0.0793341749555301 no 3054 0.0960512611547529 4408 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2826 7992541 19.48 µM -1.30526575233203 0.0791875664179385 no 3055 0.0959011857624575 4375 2985066 SGTC_1163 k060-0048 49.9 µM -1.30786993987718 0.0787555296779532 no 3056 0.0954587134370453 4369 6809982 SGTC_3294 9122953 26.2835 µM -1.30872771567819 0.0786136157451762 no 3057 0.0953132999471823 4338 16459826 SGTC_528 3492-0019 172 µM -1.31032646651864 0.0783496292680595 no 3058 0.0950427088485271 4376 2869262 SGTC_1007 4101-0031 70 µM -1.31094192979982 0.07824818307141 no 3059 0.0949386917011292 4363 1146276 SGTC_1904 st060225 78 µM -1.31184574477387 0.0780993887542641 no 3060 0.0947860933585195 4330 66595 SGTC_423 5-fluorouracil 457 µM -1.3129362513846 0.0779201453857492 no 3061 0.0946022150661206 4311 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2864 9034755 47.6 µM -1.31782996588344 0.0771196217665105 no 3062 0.0937802871157947 4309 4930451 SGTC_3147 9097027 49.47 µM -1.32286736615317 0.0763021371599662 no 3063 0.0929397447464471 4377 25236841 SGTC_171 k064-0041 9.68 µM -1.32307409322956 0.0762687302696236 no 3064 0.0929053695543554 4369 53325 SGTC_250 brefeldin a 552.239 µM -1.32404783836545 0.0761115237013813 no 3065 0.0927435787315985 4275 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2330 7979373 200 µM -1.32543694642981 0.0758876858399747 no 3066 0.0925131348280575 4312 1863007 SGTC_2940 9060638 45.86 µM -1.32699651773849 0.0756369776456998 no 3067 0.0922549172917034 4374 4027022 SGTC_2451 5856223 45.7 µM -1.32774706579407 0.0755165487650857 no 3068 0.0921308396852509 4372 2179896 SGTC_2657 nystatin 74.44 µM -1.32939982264642 0.0752518715449887 no 3069 0.0918580481632526 4411 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3121 9125696 49.47 µM -1.33208942069154 0.0748226643197134 no 3070 0.0914154031559328 4497 1235365 SGTC_2714 st079313 56.9 µM -1.33225675763348 0.0747960224606191 no 3071 0.0913879157400916 4374 2939799 SGTC_269 exalamide 29 µM -1.33245566832817 0.0747643631328989 no 3072 0.0913552498674599 4335 3316 A derivative of salicylamide. SGTC_998 3996-0085 177 µM -1.333441421036 0.0746076181323532 no 3073 0.0911934935310696 4406 715391 SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.33344150024079 0.0746076055480468 no 3074 0.0911934805425584 4509 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_74 000s-0487 160.283 µM -1.33345025840912 0.0746062140327323 no 3075 0.0911920443302615 4260 677548 SGTC_1093 fluphenazine 7.97 µM -1.33430995053131 0.0744697208052648 no 3076 0.0910511489329631 4430 6602611 An atypical antipsychotic. SGTC_1193 1488-0126 41.5 µM -1.3352151020813 0.074326216099149 no 3077 0.0909029777301626 4362 1384710 SGTC_611 3453-1652 23.7 µM -1.33752161487042 0.0739614911982171 no 3078 0.0905262158033771 4404 1560575 SGTC_1288 0973-0013 65.5 µM -1.33804167006087 0.073879445009247 no 3079 0.0904414267407818 4433 4315430 SGTC_349 k015-0014 24 µM -1.33931953752372 0.0736781384670648 no 3080 0.090233335516034 4407 2196908 SGTC_1588 farnesol 29.9 µM -1.34067597641408 0.0734649133918946 no 3081 0.0900128388411159 4409 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1376 2910-0861 41.3 µM -1.34446061445347 0.0728724833156349 no 3082 0.0893997421469256 4334 1112859 SGTC_3116 9124943 49.47 µM -1.34486221602468 0.0728098336798229 no 3083 0.0893348669879376 4363 41905195 YPL160W CDC60 SGTC_1694 st024011 44.9 µM -1.34639411029944 0.0725712375763556 no 3084 0.0890877246825288 4430 2787533 SGTC_3220 9131269 49.47 µM -1.34643144018648 0.072565430843017 no 3085 0.0890817085654166 4404 17722206 SGTC_2127 5253358 187.912 µM -1.35405137897883 0.0713875693925887 no 3086 0.0878599932550895 4318 20612 SGTC_1769 st044406 64.4 µM -1.35476979749707 0.0712772803487114 no 3087 0.0877454560440203 4383 670903 SGTC_428 3448-4153 16.5 µM -1.3580948720119 0.070768529797512 no 3088 0.0872167910880529 4363 3834874 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.36081725573919 0.0703540746883781 no 3089 0.0867857236788543 4455 91467 include heat shock SGTC_77 0828-0286 12.516 µM -1.36223804598572 0.0701385163739809 no 3090 0.0865613862552058 4306 745345 SGTC_920 mycophenolic acid 780.421 nM -1.36306242723469 0.0700136766697238 no 3091 0.0864314184508375 4388 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_138 0850-0259 40.9225 µM -1.36365258339503 0.0699244117574721 no 3092 0.0863384670471091 4336 6813004 SGTC_1993 st073995 70.8 µM -1.37151427241666 0.0687436188637266 no 3093 0.0851073487223189 4417 3098394 SGTC_461 N-acetylfarnesylcysteine 136 µM -1.37445604587549 0.0683057511774001 no 3094 0.0846500734490409 4476 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_3078 9116413 49.47 µM -1.37582266008639 0.068103071339874 no 3095 0.0844382720587961 4362 17177322 SGTC_3028 9087778 49.47 µM -1.37878521093671 0.067665295679354 no 3096 0.0839804939082147 4397 17217395 SGTC_375 3970-0961 9.27 µM -1.38013158814487 0.0674670616732411 no 3097 0.0837730664848204 4383 2898222 SGTC_2981 9013952 38.96 µM -1.38034014239488 0.0674363953503841 no 3098 0.0837409703649733 4374 2996344 SGTC_2402 5553605 200 µM -1.38121691684754 0.0673075901423659 no 3099 0.0836061374155343 4480 6758546 SGTC_2990 9074105 71.4286 µM -1.38149238740663 0.0672671605930503 no 3100 0.0835638084383418 4330 6502001 SGTC_2479 5617353 43.85 µM -1.38452850091925 0.0668228070253495 no 3101 0.0830983436739637 4427 2731746 SGTC_2952 9073731 13.78 µM -1.38490612023294 0.0667676993243651 no 3102 0.083040587685599 4425 16457353 SGTC_1669 st015249 58.4 µM -1.38583299246204 0.0666325857403701 no 3103 0.082898952757353 4550 722793 SGTC_654 1124-0271 80.9 µM -1.38874126193079 0.0662100100620809 no 3104 0.0824557211252419 4412 5403748 SGTC_843 0310-0051 143 µM -1.39194431208554 0.0657470075015724 no 3105 0.081969630955504 4452 2065037 SGTC_1396 3511-0007 98.6 µM -1.39261777351203 0.0656499783908973 no 3106 0.0818677027238444 4452 X1396 SGTC_2833 9001315 45.46 µM -1.3941360330408 0.0654316420872955 no 3107 0.081638264946319 4374 2989378 SGTC_1768 st044301 37.178 µM -1.39510470320095 0.0652926351259051 no 3108 0.081492134063165 4441 3931349 SGTC_345 1362-0200 395 µM -1.39709445147153 0.0650078192505681 no 3109 0.0811925850599358 4417 1419823 SGTC_872 0588-0139 234 µM -1.40014317559335 0.064573291765381 no 3110 0.0807352240634778 4404 2047100 SGTC_2422 chlorphenesin carbamate 384.24 µM -1.40276863182283 0.0642009026462369 no 3111 0.0803429218951977 4397 2724 A muscle relaxant with antifungal properties. SGTC_2865 9030313 51.95 µM -1.40306272686171 0.064159293009986 no 3112 0.0802990673553306 4422 42562754 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.40310349209813 0.0641535270506569 no 3113 0.0802929899975217 4351 5355888 SGTC_1659 st012954 42.1 µM -1.40540989336606 0.0638279582563177 no 3114 0.0799497132558978 4412 24207262 SGTC_2477 5967686 25.23 µM -1.41250187576639 0.0628349102693948 no 3115 0.0789011193855159 4429 776118 SGTC_2029 5175081 200 µM -1.41252350198574 0.0628319005961798 no 3116 0.0788979378248367 4404 1380876 SGTC_709 3807-1509 243 µM -1.42114186855696 0.0616414179291279 no 3117 0.077637760141726 4520 1886677 YPL242C IQG1 SGTC_1870 st057514 26.5 µM -1.43437150916867 0.0598483238356094 no 3118 0.0757331367929953 4464 5393161 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.4351814472929 0.0597398893573771 no 3119 0.0756176994867646 4440 2333 A French combination drug. SGTC_1504 k297-0033 30 µM -1.4361798461624 0.0596064356479924 no 3120 0.0754755861455949 4353 4388117 SGTC_913 3487-1245 167 µM -1.43643070437721 0.0595729407528026 no 3121 0.0754399106895721 4393 4016153 SGTC_1933 st074711 15.9 µM -1.44075704724805 0.0589976000702362 no 3122 0.0748266660189587 4450 17250958 SGTC_2627 acetyl isogambogic acid 100 µM -1.44476554764603 0.0584684269007381 no 3123 0.0742618756719954 4476 6857789 A caspase activator and apoptosis inducer. SGTC_1407 3909-7909 12.3 µM -1.44735187530794 0.0581289816576863 no 3124 0.0738991984911044 4484 4411780 SGTC_2244 6635614 200 µM -1.44747485962307 0.0581128791018929 no 3125 0.0738819863404586 4411 836499 SGTC_21 0849-0113 22.993 µM -1.45834397692008 0.0567035577459993 no 3126 0.0723728771467182 4432 1560156 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.45885350783965 0.0566381570317988 no 3127 0.0723027158471876 4429 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_445 e6 berbamine 66 µM -1.45914181766087 0.0566011774319281 no 3128 0.0722630393083871 4478 6610268 A calcium/calmodulin antagonist. SGTC_288 1315-0019 35.1 µM -1.45963370896 0.0565381296958213 no 3129 0.0721953848733059 4523 6811474 SGTC_1257 0669-0121 16 µM -1.45972381704945 0.0565265861699329 no 3130 0.0721829967233723 4462 4307855 SGTC_2328 6201408 200 µM -1.46113311772136 0.0563462856939044 no 3131 0.0719894566111417 4431 2890418 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.46331948864322 0.056067467384028 no 3132 0.0716899887367718 4558 688664 SGTC_1104 tacrolimus 29.8 µM -1.46392607773584 0.0559903048620479 no 3133 0.0716070736301576 4542 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_313 3474-0040 5.03 µM -1.46731959013628 0.0555601695002816 no 3134 0.0711445685031568 4498 1043375 YIL048W NEO1 SGTC_2730 imipramine 71.33 µM -1.46883929367805 0.0553683912152685 no 3135 0.0709381917265993 4446 3696 A tricyclic antidepressant. SGTC_2758 dehydroepiandrosterone 69.35 µM -1.47108913060956 0.055085434285403 no 3136 0.0706335070676087 4466 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_864 0469-0573 172 µM -1.48003253467122 0.053971923937727 no 3137 0.0694322821641067 4457 689425 SGTC_2908 7930301 100 µM -1.48140400325227 0.0538027543356369 no 3138 0.069249474302281 4439 2223178 SGTC_1827 berberine 7.24 µM -1.48241209171572 0.053678675358902 no 3139 0.0691153392704246 4391 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2323 6148992 148.28 µM -1.49104648640019 0.0526251869531119 no 3140 0.0679746452739261 4440 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2537 larixol 68.93 µM -1.49184334550932 0.0525287944632547 no 3141 0.0678701088654506 4470 6708759 SGTC_594 1487-1584 10.8 µM -1.49580640897515 0.0520514803003025 no 3142 0.0673520553759923 4456 5013332 SGTC_1978 st071761 42 µM -1.49683513608687 0.0519281446495308 no 3143 0.0672180806597494 4489 5147680 SGTC_1852 st056254 31.4 µM -1.49842694568976 0.0517377579747634 no 3144 0.0670111799544205 4453 442583 SGTC_177 1327-0068 8.361 µM -1.49947429014564 0.0516127943905702 no 3145 0.0668753167952982 4482 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2470 5664817 21.68 µM -1.50017350850543 0.0515295010315522 no 3146 0.0667847317886316 4540 2859561 SGTC_2100 5377183 190 µM -1.50312645002574 0.0511789144982479 no 3147 0.0664032196491161 4523 2844202 SGTC_1800 st050079 29.0735 µM -1.50615517319315 0.0508213051362417 no 3148 0.0660136719280028 4318 3645560 SGTC_247 mechlorethamine 29.705 µM -1.50618431810638 0.0508178736089276 no 3149 0.0660099319930848 4449 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_289 k017-0060 526 µM -1.50658114238299 0.0507711698013185 no 3150 0.0659590270229102 4487 5512909 SGTC_1853 st056710 91.2 µM -1.5072267017362 0.0506952644216957 no 3151 0.0658762790986928 4531 269167 SGTC_2750 bromebric acid 70.15 µM -1.5119593812755 0.0501415486761931 no 3152 0.0652720980486696 4499 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1901 st060216 58.6 µM -1.51407715543691 0.0498953391129397 no 3153 0.0650031359534315 4462 688792 SGTC_387 norethindrone acetate 66.7 µM -1.51506255601964 0.0497811069557644 no 3154 0.0648782814812312 4513 541197 SGTC_1848 st056003 16.4 µM -1.51565220238547 0.0497128522773573 no 3155 0.0648036598469089 4511 146492 SGTC_748 act1.228 77.9 µM -1.51875292577457 0.0493551549955247 no 3156 0.0644123495307458 4490 4421505 YNR035C ARC35 SGTC_231 b-estradiol 524 µM -1.52095136885335 0.0491027912918301 no 3157 0.0641360208158357 4509 450 A steroid. SGTC_762 1165-0429 115 µM -1.52268430328573 0.0489045915775096 no 3158 0.0639188534510372 4500 5967793 SGTC_1072 oxiconazole 14.9 nM -1.52423363220107 0.0487279329693654 no 3159 0.0637251796813527 4487 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2248 tofa 1.1 µM -1.52426851409119 0.0487239615223394 no 3160 0.0637208245333833 4531 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2146 5545642 200 µM -1.5257908016313 0.0485508946842997 no 3161 0.0635309861095955 4463 825326 SGTC_2131 toluylene red 5.2905 µM -1.53210426886232 0.0478383651918507 no 3162 0.0627483532534309 4467 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_879 0831-1030 162 µM -1.5333372297608 0.0477001968823564 no 3163 0.0625963930153993 4514 1549252 SGTC_1745 st081495 74 µM -1.53797989676291 0.0471827944297142 no 3164 0.0620267651156464 4372 13842402 YBL026W LSM2 SGTC_2754 granisetron 64.02 µM -1.53873968986796 0.0470985491820309 no 3165 0.061933929325155 4511 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_3082 9117008 49.47 µM -1.54244680600637 0.0466892353197245 no 3166 0.0614825274549084 4547 41448529 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.54278965379427 0.0466515250910545 no 3167 0.0614409102961005 4590 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2665 lovastatin 100 µM -1.54325898982625 0.0465999419043698 no 3168 0.0613839748302363 4559 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_666 0272-0154 136 µM -1.54621359979698 0.0462762605807288 no 3169 0.061026495053385 4520 6870312 SGTC_777 1315-0167 517 µM -1.55160154409968 0.0456906537699504 no 3170 0.0603787967374569 4550 4221767 SGTC_975 1335-0046 28.5 µM -1.55657773301861 0.0451551055601879 no 3171 0.0597853869365019 4516 16486740 SGTC_13 0199-0087 65 µM -1.55686750240515 0.0451240762399718 no 3172 0.0597509732549326 4630 4589825 SGTC_1670 st016595 4.04 µM -1.55717991392301 0.045090641560785 no 3173 0.0597138879297053 4547 597879 SGTC_1985 st071382 65.5 µM -1.56345314691165 0.0444234817663492 no 3174 0.0589730239017054 4513 6123237 SGTC_2471 5466956 24.79 µM -1.56356403963438 0.0444117602350557 no 3175 0.0589599927186858 4527 724419 SGTC_980 1473-0395 201 µM -1.56808299357327 0.0439362160911908 no 3176 0.0584308824401827 4451 768876 SGTC_2813 7971799 71.43 µM -1.5806448760889 0.042635835234707 no 3177 0.056979629441004 4527 2234054 SGTC_93 0109-0045 59.227 µM -1.58545294893094 0.0421464222101191 no 3178 0.0564317295366166 4633 88733 SGTC_1389 3405-0187 19 µM -1.5861564529138 0.0420751954333258 no 3179 0.0563519117187292 4524 799890 SGTC_1447 4239-0816 81.9 µM -1.58619654669072 0.0420711390457321 no 3180 0.0563473654599159 4552 1341554 SGTC_736 0958-0254 92.6 µM -1.58737440636241 0.0419521132101177 no 3181 0.0562139361647667 4594 6812352 SGTC_926 2268-1401 59.4 µM -1.58800334919887 0.0418886686093151 no 3182 0.0561427908922739 4505 2931578 SGTC_3138 9097216 49.47 µM -1.5886438403715 0.0418241389317523 no 3183 0.0560704122752218 4467 25237486 SGTC_1324 1418-0026 34.4 µM -1.59246096304747 0.0414412302969222 no 3184 0.0556405838508897 4555 1372513 SGTC_717 1532-0246 73.2 µM -1.59875443773521 0.0408161175486663 no 3185 0.0549375882296517 4537 9561992 SGTC_297 0986-0032 24 µM -1.60128523593461 0.040566907198555 no 3186 0.0546568787737108 4513 2847425 SGTC_2679 rapamycin 1 nM -1.61143590089755 0.0395797450368948 no 3187 0.0535423738065479 4418 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1325 1431-0015 227 µM -1.61658523321037 0.0390864875343032 no 3188 0.0529839207724553 4551 1103340 SGTC_931 2812-0076 566 µM -1.61919168153523 0.0388387285522535 no 3189 0.052703013626596 4482 3450959 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.62375390954172 0.0384081404836042 no 3190 0.0522141701998736 4577 66535 A nucleotide analog. SGTC_1485 3909-9022 254 µM -1.62484822990062 0.0383054380801707 no 3191 0.0520974507327543 4615 714516 SGTC_1816 st051957 91.6 µM -1.62690067513754 0.0381134191019689 no 3192 0.0518790972899017 4572 674121 SGTC_2092 5303694 80.6725 µM -1.62709449375568 0.0380953268105314 no 3193 0.051858515150855 4572 1963699 SGTC_824 1304-0008 100 µM -1.62857723029565 0.037957150198266 no 3194 0.0517012738625098 4575 768245 SGTC_1065 prochlorperazine maleate 2.48 µM -1.62891132924858 0.0379260719448679 no 3195 0.0516658957009257 4592 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_341 1486-1430 230 µM -1.63486661412229 0.0373755798135805 no 3196 0.0510385062794238 4517 2054753 YPL210C SRP72 SGTC_1857 st056007 79.3 µM -1.63922840700226 0.0369765410833218 no 3197 0.05058284989369 4552 619834 SGTC_1527 coumarin 137 µM -1.64176697255164 0.0367459081385038 no 3198 0.0503191530716204 4592 323 A hepatotoxic, DNA x-linker. SGTC_2715 st079500 56.4 µM -1.64886746543788 0.0361070578442137 no 3199 0.0495873948518858 4561 28246688 SGTC_3335 9143315 29.6265 µM -1.6522937397635 0.0358020559993619 no 3200 0.0492373424388488 4585 4899691 SGTC_800 3448-7362 155 µM -1.65233120300133 0.0357987327816204 no 3201 0.0492335258641563 4635 15991913 SGTC_2047 4141938 200 µM -1.65913860092484 0.0351990575843836 no 3202 0.0485439332380903 4588 3807862 SGTC_2508 celastrol 40.54 µM -1.65969730897974 0.0351502081792187 no 3203 0.0484876805072279 4510 122724 Celastrol is a natural product and antioxidant. SGTC_2593 nobiletin 86.24 µM -1.66750758612048 0.0344731389140845 no 3204 0.0477067586147441 4543 72344 An anti-infammatory. SGTC_1221 2958-7315 257 µM -1.67146155284792 0.0341344783889233 no 3205 0.0473152733581761 4604 4562705 SGTC_1415 3966-0071 78.1 µM -1.67256085135408 0.034040810032802 no 3206 0.0472068895874858 4495 2893185 SGTC_300 r073-0011 5.04 µM -1.67415310957582 0.0339055127494957 no 3207 0.0470502561287968 4580 2735780 SGTC_2796 7949634 45.45 µM -1.67416850086126 0.0339042070836149 no 3208 0.0470487440948417 4548 2971588 SGTC_2614 arthonioic acid 13.39 µM -1.67423059419167 0.0338989400330331 no 3209 0.0470426444656141 4441 6710684 SGTC_3191 9110352 49.47 µM -1.6745365720272 0.033872995371799 no 3210 0.0470125965303508 4526 17122424 SGTC_1719 st032227 49.2 µM -1.67496755772757 0.0338364786761539 no 3211 0.0469702985578657 4561 3125804 SGTC_2966 9084041 48.03 µM -1.67783856358252 0.0335940487779331 no 3212 0.0466893093683514 4526 17741380 SGTC_1173 0443-0020 122 µM -1.6791708914712 0.0334820326406625 no 3213 0.0465593716138154 4573 5331295 SGTC_2756 carbadox 75.1 µM -1.68010481920461 0.033403695657401 no 3214 0.0464684617114236 4502 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2043 5101342 149 µM -1.68017642339695 0.0333976957987989 no 3215 0.0464614975386018 4604 678451 SGTC_2203 7227154 166.4 µM -1.68545638699123 0.0329577161316068 no 3216 0.0459502762484896 4600 896304 SGTC_1234 0326-0494 15.5 µM -1.68741986066683 0.0327953230701496 no 3217 0.0457613237869228 4628 1547813 SGTC_1661 st013063 9.66 µM -1.68917670418696 0.0326505795024174 no 3218 0.0455927859656945 4645 721395 SGTC_982 1491-0518 27.5 µM -1.69046049871289 0.0325451431712153 no 3219 0.0454699446278798 4546 3091256 SGTC_583 1488-1091 88.9 µM -1.70537028838439 0.0313410676070319 no 3220 0.0440626930206593 4676 4303273 SGTC_2354 9060492 162 µM -1.70710611065994 0.031203312347953 no 3221 0.0439011657763047 4584 6471895 SGTC_1278 0874-0585 172 µM -1.70947362158338 0.031016233864538 no 3222 0.0436816269240236 4614 766306 SGTC_405 ebelactone b 50 µM -1.71311044243975 0.0307306643284792 no 3223 0.0433461116410873 4560 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_711 k292-0785 179 µM -1.71431349445906 0.0306366791008716 no 3224 0.0432355830550631 4537 4146315 SGTC_3053 9095903 49.47 µM -1.7245729365963 0.0298448192626762 no 3225 0.0423022320827971 4692 17174018 SGTC_15 0266-0086 27.098 µM -1.72551757749773 0.0297727699871935 no 3226 0.0422171194196529 4662 1712902 YIL048W NEO1 SGTC_253 dyclonine 31.25 µM -1.72559050909918 0.0297672133829152 no 3227 0.0422105540085606 4683 3180 An oral anasthetic. SGTC_2733 amorolfine 100 µM -1.72716392845964 0.0296475450935092 no 3228 0.0420691135293469 4735 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1082 camptothecin 424.86 nM -1.73227055143518 0.0292619023008315 no 3229 0.0416127013218709 4477 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2845 9003024 42.97 µM -1.73666859282955 0.0289331181384831 no 3230 0.0412228422497514 4610 2990173 SGTC_1664 st014217 9.02 µM -1.73715236680095 0.0288971408496682 no 3231 0.0411801400568284 4668 3982782 SGTC_2460 5552655 174.22 µM -1.73878000754306 0.0287763694218603 no 3232 0.0410367332630046 4575 5401989 SGTC_1763 st044482 94.5 µM -1.74357367052005 0.0284231139688407 no 3233 0.040616728886612 4586 88505 SGTC_2058 5236698 133 µM -1.74479144933446 0.0283339502011004 no 3234 0.0405105888814305 4580 766665 SGTC_853 0419-0306 21 µM -1.74565711525478 0.0282707092115178 no 3235 0.0404352755853681 4654 762713 SGTC_2241 6772625 37.8075 µM -1.74627801223393 0.0282254221402701 no 3236 0.0403813273325508 4415 2285411 SGTC_914 3820-6779 408 µM -1.74867160016553 0.0280514030418951 no 3237 0.0401739009272071 4538 2893481 SGTC_2786 7743617 45.45 µM -1.75083467688146 0.0278949120050055 no 3238 0.0399871957577891 4535 583674 SGTC_2037 5169046 200 µM -1.75522701842173 0.027579378611397 no 3239 0.0396102420830489 4651 5718022 SGTC_1190 1486-1332 13 µM -1.75569028386674 0.027546273064229 no 3240 0.03957065336608 4612 4150046 SGTC_2251 lansoprazole 556 µM -1.76516046542479 0.0268767493233373 no 3241 0.0387684004468298 4596 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1122 capsaicin 818.572 nM -1.77400030208959 0.0262641029318951 no 3242 0.0380315501710977 4628 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_509 pifithrin 175 µM -1.77423605405807 0.0262479252719338 no 3243 0.0380120564174551 4694 4817 A p53 inhibitor. SGTC_244 nsc-207895 1.295 µM -1.78156138754136 0.0257493855097523 no 3244 0.0374103929125059 4444 42640 SGTC_526 4469-0568 170 µM -1.79801815076539 0.0246582379106696 no 3245 0.0360870657383427 4598 2901964 SGTC_2582 agaric acid 100 µM -1.80540275476222 0.0241813698381534 no 3246 0.0355058402045876 4269 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1264 0783-0040 158 µM -1.80587128722482 0.0241513770318884 no 3247 0.0354692235071154 4541 2855798 SGTC_2731 amoxapine 43.43 µM -1.8148983033534 0.023579591639256 no 3248 0.0347697696698717 4751 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2945 9067681 61.76 µM -1.82396917516197 0.0230165407460821 no 3249 0.0340783662455865 4664 16456930 SGTC_850 0388-0143 75.9 µM -1.82690922922542 0.0228364919739698 no 3250 0.0338567091849847 4642 67273 SGTC_704 1310-0270 142 µM -1.82786866093003 0.0227779938433178 no 3251 0.0337846327240453 4614 5718033 SGTC_1737 st035557 69.7 µM -1.8301181855932 0.0226413315865216 no 3252 0.0336161340800623 4496 5716916 SGTC_1984 st072354 53.1 µM -1.83113783827943 0.02257961406033 no 3253 0.0335399860313919 4548 5762938 SGTC_3302 9125395 16.351 µM -1.83643336245234 0.022261363190416 no 3254 0.0331467945746335 4601 17599668 SGTC_1934 st074720 32.6 µM -1.84403566498719 0.0218111018336618 no 3255 0.0325889713410901 4581 17250992 SGTC_1578 josamycin 24.2 µM -1.84536310539629 0.0217332756930713 no 3256 0.0324923681673721 4635 5282165 A P450 substrate. SGTC_3274 9138298 49.47 µM -1.84720340111633 0.0216257696512076 no 3257 0.0323588333248883 4608 17015756 SGTC_3211 9128781 49.47 µM -1.8623358891026 0.0207586855982375 no 3258 0.0312778798643105 4548 17194361 SGTC_662 k832-1615 104 µM -1.86538571083053 0.0205875440043127 no 3259 0.0310636794048938 4662 5878478 SGTC_1915 st067105 30.6 µM -1.87225265303035 0.0202065747241599 no 3260 0.0305858288733411 4586 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_3304 9125678 46.087 µM -1.87263774693828 0.0201853883839078 no 3261 0.0305592125898432 4612 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_3156 9099931 49.47 µM -1.87556170687769 0.0200251373533799 no 3262 0.0303577443825614 4677 18111053 SGTC_2433 5607874 27.82 µM -1.87658118815848 0.0199695178248326 no 3263 0.0302877588343578 4616 2252428 SGTC_419 nsc-638432 893 µM -1.88818729179285 0.0193455127161668 no 3264 0.029500405633184 4640 368090 SGTC_2912 7964298 10.93 µM -1.89012656494431 0.0192428797005814 no 3265 0.0293705175167605 4634 2975850 SGTC_1957 st077035 62.4 µM -1.90145872890781 0.018652351715228 no 3266 0.0286209766836731 4669 705593 SGTC_839 0122-0028 230 µM -1.90808246141952 0.0183143803321982 no 3267 0.0281902795768293 4671 759448 SGTC_246 cycloheximide 667 µM -1.91056235632016 0.0181891947022995 no 3268 0.0280304229112385 4635 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2844 9010103 25.97 µM -1.91329969016768 0.01805186094515 no 3269 0.0278548486921409 4608 2480525 SGTC_1958 st076513 41.9 µM -1.91393247691337 0.0180202397339369 no 3270 0.0278143920140695 4596 732122 YGL099W LSG1 SGTC_2005 4024620 188 µM -1.91734459769363 0.0178505441591416 no 3271 0.0275970838263852 4616 236743 SGTC_3192 9110362 49.47 µM -1.92024677946101 0.0177072840055036 no 3272 0.0274133676536127 4647 16649480 SGTC_1819 st053448 58.6 µM -1.92382040402347 0.0175322282905044 no 3273 0.0271885494751362 4629 2857616 SGTC_1045 1348-1485 165 µM -1.93776905731309 0.0168630148944028 no 3274 0.0263257022222207 4642 6810614 SGTC_304 1310-0298 97 µM -1.93818843092612 0.0168432376478998 no 3275 0.0263001188432627 4418 1550234 SGTC_433 pimozide 108 µM -1.94420036376686 0.0165618941474993 no 3276 0.0259356469742807 4613 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1242 0402-0103 60.1 µM -1.95923709214958 0.0158757669284222 no 3277 0.0250425135497326 4606 432868 SGTC_2136 5328288 199.296 µM -1.96933339793195 0.0154288728499611 no 3278 0.0244574091940381 4643 262395 SGTC_2026 5148700 152 µM -1.97467563098668 0.0151968088472664 no 3279 0.024152485055657 4674 79838 SGTC_1963 st076565 50.3 µM -1.97693450420896 0.0150995901900234 no 3280 0.0240245170028514 4701 4914280 SGTC_1986 st071812 45 µM -1.98154785051551 0.0149026977153293 no 3281 0.0237649343947914 4639 11838594 SGTC_2807 7945238 51.95 µM -1.98316131707305 0.0148343597324064 no 3282 0.0236747066274828 4645 17148797 SGTC_1425 4048-4433 7.33 µM -1.98559683002687 0.0147317146395608 no 3283 0.023539054365909 4734 23734946 SGTC_1457 k015-0032 57.3 µM -1.98797671376295 0.0146320048181223 no 3284 0.0234071327088923 4684 4302660 SGTC_1431 4049-0260 9.09 µM -1.99280869656198 0.014431344813645 no 3285 0.023141199557292 4712 3854841 SGTC_1910 st062352 60.4 µM -1.99967984474453 0.0141500856166373 no 3286 0.0227674229747833 4613 2245730 SGTC_972 1319-0219 195 µM -2.00688254935058 0.0138603377661101 no 3287 0.0223810851899621 4670 23903702 SGTC_1614 st002383 48.6 µM -2.02039231355526 0.0133306519811423 no 3288 0.0216713550440244 4714 1947235 SGTC_401 neomycin 50 µM -2.02068210863715 0.0133194840343952 no 3289 0.0216563415375752 4695 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2581 avocatin a 64 µM -2.02166420648724 0.013281696621642 no 3290 0.0216055270210861 4617 6710728 A skin care supplement. SGTC_1612 st002233 45.4 µM -2.02449762477811 0.0131731959415125 no 3291 0.02145948805981 4708 1035021 SGTC_2659 sanguinarine 24.21 µM -2.03210571114987 0.0128856393932815 no 3292 0.0210714776743647 4671 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1290 0986-0249 10.2 µM -2.0398375300498 0.0125989840385808 no 3293 0.020683255224795 4602 53329 SGTC_605 1315-0399 119 µM -2.05788294049072 0.0119513457281537 no 3294 0.0198006858611299 4729 24020461 SGTC_2600 tangeritin 87.95 µM -2.06681820679043 0.0116414933478763 no 3295 0.0193756436109568 4646 68077 A bioactive flavone. SGTC_272 doxorubicin 8.13 µM -2.06889746638747 0.0115703983440485 no 3296 0.0192778546998616 4717 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_61 0978-8327 98.565 µM -2.08259470953965 0.0111114109575669 no 3297 0.0186440909298465 4653 6150059 YHR072W ERG7 SGTC_2409 alverine citrate 63.97 µM -2.09877550994305 0.0105896729563585 no 3298 0.0179183473300111 4670 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1526 st051518 75 µM -2.09950736028162 0.0105665880269897 no 3299 0.0178860998404204 4679 673993 SGTC_2943 9068529 45.32 µM -2.10644482981568 0.0103499264752593 no 3300 0.0175828653298325 4664 3270634 SGTC_2459 5811157 9.22 µM -2.12853752683239 0.0096855569576045 no 3301 0.0166462709940088 4679 2870684 YBR192W RIM2 SGTC_438 sphingosine 6.67 µM -2.14501404943848 0.00921463285079285 no 3302 0.0159758618488714 4681 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_680 0417-1641 114 µM -2.14731964042755 0.00915036023502703 no 3303 0.0158839216347498 4736 2835990 SGTC_2732 terfenadine 20 µM -2.16548918905839 0.00865743842207814 no 3304 0.015175121213383 4759 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2624 nerol 100 µM -2.17093225277973 0.00851437964255855 no 3305 0.0149681469330574 4650 637566 A natural product oil. SGTC_2423 st077119 87.2 µM -2.17251068791444 0.00847328388235442 no 3306 0.0149085821807804 4657 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -2.17821260876641 0.00832627669620434 no 3307 0.0146951058933197 4745 279621 SGTC_1046 2001-0062 216 µM -2.20406276507257 0.00768754170747771 no 3308 0.0137599651561671 4701 739778 SGTC_3051 9093778 49.47 µM -2.23452403357097 0.00699055340279464 no 3309 0.0127243064989324 4775 17217378 SGTC_499 genistein 192 µM -2.24116525911383 0.00684621836692496 no 3310 0.0125076861457305 4766 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_58 0957-0393 9 µM -2.24338223817912 0.00679862575821841 no 3311 0.0124360881360029 4262 6997992 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -2.27095003643325 0.00623077849036041 no 3312 0.011575001365029 4750 5106787 A p450 inhibitor. SGTC_999 SEC7.066 22.7 µM -2.2727817847069 0.00619458081609461 no 3313 0.011519666630546 4726 740511 YDR170C SEC7 SGTC_3196 9111891 49.47 µM -2.28432046495897 0.00597081410637225 no 3314 0.0111763520136843 4709 18891510 SGTC_302 1094-0063 18.9 µM -2.29543512919133 0.00576207683142782 no 3315 0.010854100040779 4747 5440289 SGTC_1743 st037606 46.3785 µM -2.30048017568805 0.00566948487038361 no 3316 0.0107105155756231 4702 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_909 3448-9333 149 µM -2.31217501075309 0.00545991142749296 no 3317 0.0103840204000752 4708 3344074 SGTC_555 4296-0685 37 µM -2.35338269400199 0.0047752682703625 no 3318 0.00930173833956503 4747 2908540 YHR072W ERG7 SGTC_2710 st078562 53.7235 µM -2.3686778546978 0.00454132018420183 no 3319 0.00892589746775602 4738 17250908 SGTC_831 k061-1017 217 µM -2.42244264867456 0.00379803368653158 no 3320 0.00770827949945107 4763 1240153 SGTC_3070 9117005 49.47 µM -2.42584362179829 0.00375490937393854 no 3321 0.00763642482064914 4775 8779016 SGTC_2792 7535235 81.82 µM -2.4441078663208 0.00353074252452249 no 3322 0.00726054212506686 4713 1281891 SGTC_1609 st001574 46.4 µM -2.46225155172279 0.00332002780671484 no 3323 0.0069033896399638 4758 3960012 SGTC_2735 sertaconazole 140 nM -2.48883222050861 0.00303171810243695 no 3324 0.00640817162196525 4793 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2903 5923464 63.88 µM -2.51072027337531 0.00281145852616215 no 3325 0.0060242563688843 4767 2876576 SGTC_560 2332-1943 155 µM -2.51299820427725 0.00278938587833377 no 3326 0.00598549721304289 4763 21177716 SGTC_1465 k213-0056 144 µM -2.52912187831617 0.00263756920422297 no 3327 0.00571741558348767 4719 24048857 YMR208W ERG12 SGTC_2755 lomerizine 42.69 µM -2.53501592298988 0.00258396252076883 no 3328 0.00562211074469961 4734 3949 A calcium channel blocker. SGTC_303 1348-1668 34.2 µM -2.54236723693685 0.00251848253507152 no 3329 0.00550522106250187 4777 5380509 SGTC_2171 5739187 198.077 µM -2.58990114655936 0.0021300798412722 no 3330 0.00480017479649059 4749 2262761 SGTC_3074 9116018 49.47 µM -2.62046168353364 0.00190993846150674 no 3331 0.00439053986439566 4767 17027303 SGTC_2173 5763948 167 µM -2.63925184998136 0.00178506138543298 no 3332 0.00415446141996155 4778 2867177 SGTC_3331 9141060 1.957 µM -2.66871554660595 0.00160414066601424 no 3333 0.00380709524644657 4752 4906567 YPR165W RHO1 SGTC_55 0767-0285 6.563 µM -2.67748293520104 0.00155362599684962 no 3334 0.00370888155312945 4754 3116166 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -2.68936803389699 0.0014874632367429 no 3335 0.00357937228071148 4784 16486 A toxic proline analog. SGTC_981 1488-1094 54.9 µM -2.78000763632386 0.00106151261066827 no 3336 0.00271788100972268 4769 3449522 SGTC_1391 3442-0225 151 µM -2.82548481620606 0.000892936797696813 yes 3337 0.00236045627039305 4786 5227075 SGTC_2293 7624732 200 µM -2.83056365457657 0.000875723694290009 yes 3338 0.00232330320443284 4741 894453 SGTC_3046 9092212 49.47 µM -2.85480583089227 0.00079768883779328 yes 3339 0.00215315739232733 4792 25236637 SGTC_2357 9067248 200 µM -2.8615565566828 0.000777127414876925 yes 3340 0.00210783140615164 4752 9150235 SGTC_661 1304-0007 33.6 µM -3.00554632669203 0.000439528290973737 yes 3341 0.0013255210444944 4792 3117130 SGTC_525 k781-2675 26.7 µM -3.0264547742518 0.000403790143846626 yes 3342 0.0012371991688703 4773 3651118 YDL195W SEC31 SGTC_3321 9137793 26.8275 µM -3.03880820400761 0.000383961950101875 yes 3343 0.0011875800744045 4790 4904192 SGTC_1331 1472-0049 76.2 µM -3.10300560840369 0.000294696125644987 yes 3344 0.000957830050029329 4793 24051409 SGTC_2811 7967822 32.47 µM -3.27992209107976 0.000138549676135125 yes 3345 0.00051917878260218 4794 2232244 SGTC_2417 cerulenin 830 nM -3.32369473057105 0.000114285616060103 yes 3346 0.000444166893196538 4791 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -3.59716289071464 3.25771981353725e-05 yes 3347 0.000160853516284475 4806 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_616 4092-0450 108 µM -3.70342790407372 1.95214529260067e-05 yes 3348 0.000106352825441087 4801 787165 SGTC_1839 st053978 48 µM -3.70713536414076 1.91710314130462e-05 yes 3349 0.000104808456976412 4807 3788398 SGTC_1909 st060837 51.5 µM -3.72547785821878 1.75234240047553e-05 yes 3350 9.74727824853069e-05 4800 678937 SGTC_1757 st041620 31.8375 µM -3.78424281720479 1.31036680963963e-05 yes 3351 7.70886220052185e-05 4801 5289815 SGTC_3077 9117319 49.47 µM -3.83550156464773 1.01344944573173e-05 yes 3352 6.26541542843456e-05 4791 17154678 SGTC_750 4073-0104 132 µM -4.21103495267583 1.3991202675124e-06 yes 3353 1.27101703844063e-05 4756 22330957 SGTC_614 0462-0418 107 µM -4.6440248090362 1.15157678347703e-07 yes 3354 1.7084325246135e-06 4755 5188303 SGTC_1107 amlodipine 47 µM -4.70283971449643 8.05849409865632e-08 yes 3355 1.28283916825822e-06 4703 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_613 3914-0030 117 µM -5.21244646995206 3.05715945048873e-09 yes 3356 9.31831774179705e-08 4767 1145395