SGTCid condition conc unit GUD1|YDL238C.score GUD1|YDL238C.strain.pval GUD1|YDL238C.strain.significant GUD1|YDL238C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1565 sinapyl alcohol 95.1 µM 7.56665356978404 4.58177854752235e-14 yes 1 1.91480697614951e-14 1 5280507 A phenol propionate derived from cinnamic acid. SGTC_1962 st076595 64.5 µM 5.82580115492827 4.70819752744242e-09 yes 2 2.84196302693024e-09 7 279619 SGTC_2557 derrustone 83.84 µM 5.22224629775077 1.31964615438507e-07 yes 3 8.83828212621512e-08 12 629853 An antioxidant. SGTC_2147 5545932 89.7195 µM 4.80487636836323 1.08344976604225e-06 yes 4 7.74235789525334e-07 4 797404 SGTC_2165 5727197 32.143 µM 4.77927257188596 1.22631243651717e-06 yes 5 8.79652761796062e-07 22 1361712 SGTC_2145 5634607 200 µM 4.71584988624821 1.6622906346883e-06 yes 6 1.20351929943069e-06 2 308662 SGTC_1575 cyproterone acetate 48 µM 4.63561512376448 2.42941322043964e-06 yes 7 1.77938795259886e-06 9 9880 An androgen receptor antagonist and liver toxin. SGTC_2830 7992007 71.43 µM 4.55214190952914 3.58251261238621e-06 yes 8 2.65512478285344e-06 14 1952075 SGTC_856 0433-0016 11.3 µM 4.52203769621654 4.11465847982373e-06 yes 9 3.06235742984206e-06 8 3911780 SGTC_190 3970-0790 3.722 µM 4.37100554707338 8.13902933672578e-06 yes 10 6.18378252635289e-06 4 2832352 SGTC_1451 4152-0210 104 µM 4.37022710044856 8.16724700163502e-06 yes 11 6.20586919295848e-06 15 659563 SGTC_212 3807-4682 38.772 µM 4.311861447114 1.0570067168879e-05 yes 12 8.09429349861008e-06 50 3125501 YBL034C STU1 SGTC_1762 st045503 25.4615 µM 4.20559116360751 1.67684167121735e-05 yes 13 1.30200297696029e-05 21 4645554 SGTC_288 1315-0019 35.1 µM 4.13327378010673 2.28182997705716e-05 yes 14 1.78816144782161e-05 18 6811474 SGTC_1746 st038117 42 µM 4.04918349084834 3.24503826949675e-05 yes 15 2.56983182655554e-05 30 2898218 SGTC_2777 climbazole 1.536 µM 4.04424866290093 3.31212673224311e-05 yes 16 2.62455924518929e-05 46 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 4.02689725979814 3.55858794415073e-05 yes 17 2.82588564833448e-05 10 688798 SGTC_2558 carylophyllene oxide 100 µM 3.88808554401564 6.25623102036771e-05 yes 18 5.05190095997984e-05 13 6708694 An oxygenated terpenoid and antifungal agent. SGTC_196 k015-0023 18.111 µM 3.80279883715831 8.77102567940763e-05 yes 19 7.15352629454855e-05 24 5211998 SGTC_290 2043-6722 48.1 µM 3.5699679240062 0.000213260352830558 yes 20 0.000178512471137821 18 773758 YLR208W SEC13 SGTC_2070 5230947 200 µM 3.47855652211416 0.000298212158172694 yes 21 0.000252061055566832 22 2835538 SGTC_551 k048-0028 34.9 µM 3.45369158556811 0.000326259152175958 yes 22 0.00027648468577931 34 6836383 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 3.42494398025387 0.000361735731326568 yes 23 0.000307463100196985 44 688664 SGTC_2337 9009472 200 µM 3.37241237002733 0.000435979701447939 yes 24 0.000372563967566059 56 5742383 SGTC_2466 5983409 37.09 µM 3.33170666593101 0.000502969466553009 yes 25 0.000431575920935153 38 2879657 SGTC_2767 sibutramine 71.45 µM 3.3041373357122 0.000553622502547596 yes 26 0.000476345748009922 38 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2779 methotrexate 400 µM 3.29573627985829 0.000569971067283335 yes 27 0.000490820584904822 50 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_3349 9149703 23.001 µM 3.27619116758272 0.000609747901184473 yes 28 0.000526086578091613 31 4910494 SGTC_648 0375-0473 33.3 µM 3.25639746409846 0.000652630584962382 yes 29 0.000564178383482974 40 1713139 SGTC_77 0828-0286 12.516 µM 3.23592378227439 0.000699901002792402 yes 30 0.000606248773438847 70 745345 SGTC_295 k015-0027 31 µM 3.13597619267697 0.000979334440026874 yes 31 0.000856415537340873 32 3887424 SGTC_114 0364-0001 490.298 µM 3.13521904745452 0.000981796099616627 yes 32 0.000858629160329803 98 4003655 SGTC_46 0329-0187a 2.197 µM 3.11992753801909 0.00103274421756768 no 33 0.000904477669722166 123 46494817 SGTC_450 aminopyrene 156 nM 3.10497576342451 0.00108489485070181 no 34 0.000951473083622035 75 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2154 5570129 200 µM 3.08194977354106 0.00116994426635854 no 35 0.00102824766929327 54 673366 SGTC_1188 1403-0014 4.57 µM 3.07846925936285 0.0011833185222999 no 36 0.0010403349743447 107 9614867 SGTC_2691 st077356 60.2 µM 3.06454814996818 0.00123822326492477 no 37 0.00108999539929761 72 2839272 SGTC_1822 st052468 42 µM 3.04928308217156 0.00130110056543728 no 38 0.0011469411054509 34 2873678 SGTC_720 r052-1644 49.9 µM 3.02213714886767 0.00142017194549568 no 39 0.00125498399472023 61 1422863 YOR257W CDC31 SGTC_2541 muurolladie-3-one 83.07 µM 3.02199363808556 0.00142082704983929 no 40 0.00125557912914297 70 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2253 7938677 135.83 µM 3.02085294198136 0.00142604397030815 no 41 0.0012603187470944 45 2301972 SGTC_1968 st069590 43.6 µM 3.01163194490561 0.00146886217845135 no 42 0.00129923723361205 41 6384066 SGTC_3010 9080089 71.4286 µM 2.99445734956258 0.00155175453675385 no 43 0.00137466745354179 58 17027233 SGTC_2380 9035439 200 µM 2.98369107241155 0.00160586966535041 no 44 0.00142397077791981 81 6462575 SGTC_1106 tegaserod maleate 11.7 µM 2.97728648560207 0.00163887164470727 no 45 0.00145406062958567 77 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2821 7996764 71.43 µM 2.97606510042091 0.00164523498913381 no 46 0.00145986437491213 103 2987135 SGTC_1329 1447-1697 50.6 µM 2.96949167296399 0.00167987030537247 no 47 0.00149146448383487 49 2840515 SGTC_2012 4023501 200 µM 2.95553021178466 0.00175564552710265 no 48 0.0015606606266931 84 3477460 SGTC_2083 5306046 65.942 µM 2.95036319154114 0.00178446881047602 no 49 0.00158700288394132 80 539837 SGTC_3163 9099914 49.47 µM 2.92202350753423 0.00195035198182265 no 50 0.00173882645811242 12 16268368 SGTC_296 1222-0039 74.9 µM 2.90007657958878 0.00208830740462808 no 51 0.00186535750851274 56 5984176 SGTC_1386 3228-0095 33.8 µM 2.88310358186522 0.00220100366920001 no 52 0.00196888966118544 55 870181 SGTC_149 3970-0822 46.1 µM 2.87329221919842 0.00226863538425917 no 53 0.00203109093966269 201 3114250 YBL034C STU1 SGTC_1622 st003707 19.4 µM 2.86768350150611 0.00230813776266123 no 54 0.00206744471556828 115 10140899 SGTC_249 wiskostatin 11.211 µM 2.85600005900738 0.00239243144048905 no 55 0.0021450752722029 59 2775510 A n-wasp and actin depolymerizer. SGTC_3026 9090633 49.47 µM 2.85214212087916 0.00242087155030225 no 56 0.00217128401792042 75 25236842 SGTC_2062 5245942 200 µM 2.81086249965541 0.00274489297027596 no 57 0.002470444801734 76 1376160 SGTC_2366 9070441 60.58 µM 2.73428073632458 0.00345133717849021 no 58 0.00312583585738087 105 6837235 SGTC_298 1391-0729 10 µM 2.71308141188742 0.00367383976542143 no 59 0.00333303636215572 66 3237558 SGTC_2153 5569715 200 µM 2.70900434815575 0.00371807836267261 no 60 0.00337427276583525 53 2054701 SGTC_2026 5148700 152 µM 2.69991365863485 0.00381844254759466 no 61 0.00346787366566219 83 79838 SGTC_2675 theaflavin digallate 100 µM 2.68678429828122 0.0039676825010869 no 62 0.00360717622815399 103 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1982 st072467 71.9 µM 2.66855046170575 0.00418360773917026 no 63 0.00380896670912586 136 3163533 SGTC_2686 alizarin 95.37 µM 2.6658416756653 0.00421656661898781 no 64 0.00383979250166251 105 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_622 1348-1566 26.3 µM 2.65105922010839 0.00440055551895262 no 65 0.0040119885490945 96 7340407 SGTC_2570 licareol 100 µM 2.650613775565 0.00440620936672261 no 66 0.00401728304199477 108 443158 SGTC_3355 9151058 44.0485 µM 2.64359147754683 0.00449620220517015 no 67 0.00410157980352865 65 17015728 SGTC_2653 dihydrofissinolide 100 µM 2.61276230208925 0.00491100687495764 no 68 0.00449068715619721 51 6857746 SGTC_37 0566-0070 1.56 µM 2.59953807556097 0.00509915420540298 no 69 0.00466746609817941 127 1626686 SGTC_1826 st055655 41.6 µM 2.59584117959973 0.00515288683134655 no 70 0.00471798349945097 126 676168 SGTC_1893 st059353 36.1 µM 2.59024343133995 0.00523520685361495 no 71 0.00479540421908953 107 3112488 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 2.58936573990941 0.0052482196748095 no 72 0.00480764548676682 117 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2990 9074105 71.4286 µM 2.5857191352959 0.00530259358371347 no 73 0.00485880397671423 73 6502001 SGTC_2441 5730946 39.09 µM 2.58471497785178 0.00531765411849326 no 74 0.00487297631696781 104 1774275 SGTC_1464 k208-0027 110 µM 2.56000482903104 0.0057004465700712 no 75 0.00523353544065062 101 X1464 SGTC_1199 1638-0010 4.46 µM 2.54658739621919 0.00591838485046902 no 76 0.00543909841765755 119 3111136 SGTC_68 0986-0284 82.829 µM 2.53547189960431 0.00610449629063155 no 77 0.00561479687727741 188 423278 YIL048W NEO1 SGTC_923 1900-2434 73.3 µM 2.5302993000138 0.00619285785899289 no 78 0.00569826321725471 127 5910570 SGTC_2364 9055074 200 µM 2.50710402883968 0.00660317522853499 no 79 0.0060862440458083 101 6470630 SGTC_2300 7976697 71.57 µM 2.48684805482608 0.00698097006041068 no 80 0.00644402155992346 124 2236109 SGTC_1928 4'-methoxychalcone 40.3 µM 2.48413508368182 0.00703299211383324 no 81 0.0064933267110415 85 641818 SGTC_22 0964-0034 14.468 µM 2.46415046552389 0.00742686002712262 no 82 0.00686692219507454 160 138402 SGTC_1638 st008370 60.6 µM 2.43029751071611 0.00813851958780645 no 83 0.00754321667817814 149 24207134 SGTC_1681 tripelennamine 100 µM 2.42454947168816 0.0082651307528237 no 84 0.00766369740974481 105 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1707 st032323 6.317 µM 2.41247873685765 0.00853665444277525 no 85 0.00792223080193592 189 3132057 YMR211W DML1 SGTC_2199 6590217 200 µM 2.41068304371978 0.00857770911272243 no 86 0.00796133959366907 54 703109 SGTC_3208 9114115 49.47 µM 2.40710285364652 0.0086600796973852 no 87 0.00803982028182628 153 650895 SGTC_3147 9097027 49.47 µM 2.40544503773716 0.00869845601720727 no 88 0.00807639075468333 129 25236841 SGTC_884 0851-0618 334 µM 2.37787438354571 0.00935889848114971 no 89 0.00870637833029748 136 9642473 SGTC_2318 6029776 164 µM 2.3693059154216 0.00957289723020986 no 90 0.00891075297240763 157 818325 SGTC_753 1322-0200 289 µM 2.36764457404789 0.00961488098994514 no 91 0.00895086214760107 127 5403907 SGTC_1149 3909-7961 23.3 µM 2.36582627265302 0.00966101565827377 no 92 0.00899494195799227 154 735261 SGTC_2654 protoveratrine a 100 µM 2.3648138984303 0.0096867857637758 no 93 0.00901956655141745 93 5702278 A heart drug and vasodilator. SGTC_608 k048-0125 159 µM 2.36226495134841 0.00975193567866673 no 94 0.0090818277892008 119 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_906 1165-0455 526 µM 2.36193742875874 0.00976033469633848 no 95 0.00908985516359571 90 3252859 SGTC_2264 7948757 110.76 µM 2.3615589928566 0.00977004720790428 no 96 0.00909913812766638 134 2971411 SGTC_2842 9000675 19.48 µM 2.35870097944533 0.00984367081222934 no 97 0.0091695131425175 147 2989072 SGTC_2488 5268135 45.7 µM 2.35282984462175 0.00999643509388372 no 98 0.0093155787494151 191 1270356 YLR208W SEC13 SGTC_3053 9095903 49.47 µM 2.34433393323942 0.0102211575062165 no 99 0.00953054841257347 71 17174018 SGTC_2164 5685496 200 µM 2.33500269074856 0.0104730404126484 no 100 0.00977164008628569 118 759046 SGTC_1965 Pectolinarigenin 58.4 µM 2.33193771720496 0.010556946720379 no 101 0.00985198395859721 109 5320438 An anti-inflammatory. SGTC_1845 st056753 3.01 µM 2.32362827002089 0.0107873777027259 no 102 0.0100727129592173 175 5375839 SGTC_2401 5128683 200 µM 2.30962635785399 0.0111855797943928 no 103 0.0104544245267396 167 708373 SGTC_2662 daunorubicin 22.37 µM 2.30882946089077 0.0112086223206442 no 104 0.0104765232581003 131 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_858 0438-0351 2.77 µM 2.30671653663188 0.0112699180604017 no 105 0.0105353138791515 156 2799119 SGTC_1773 st048542 73.5835 µM 2.30626119029777 0.0112831657106319 no 106 0.0105480211503984 180 3237138 SGTC_3317 9138495 8.753 µM 2.30348824371036 0.0113641331726446 no 107 0.0106256939325279 146 17020139 SGTC_2680 butyl paraben 22.24 µM 2.30068460143981 0.0114465097266141 no 108 0.0107047325520902 104 7184 An antifungal and steroid mimetic. SGTC_2713 st079149 53.4 µM 2.2953450528461 0.0116048317652564 no 109 0.0108566788073836 162 3103253 SGTC_3186 9110464 49.47 µM 2.29247401407343 0.0116907438777388 no 110 0.0109391526877599 120 17018021 SGTC_1718 roemerine 11.9335 µM 2.2912438048443 0.0117277249259536 no 111 0.0109746583663299 216 235224 An aporphine alkaloid with mutagenic activity. SGTC_931 2812-0076 566 µM 2.28834123246599 0.0118153811293823 no 112 0.0110588285476018 161 3450959 SGTC_3070 9117005 49.47 µM 2.28322696819308 0.0119712130248906 no 113 0.0112085011750436 84 8779016 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 2.28024029992024 0.0120630388882124 no 114 0.0112967201959998 106 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2391 6285546 200 µM 2.27914492241906 0.0120968692744145 no 115 0.011329225939886 170 846083 SGTC_2240 6690706 185.951 µM 2.27761571975405 0.0121442357616669 no 116 0.0113747415422359 118 805876 SGTC_2185 6113692 200 µM 2.25671461208198 0.0128079325377418 no 117 0.0120129566031731 131 874150 SGTC_2417 cerulenin 830 nM 2.25577225327253 0.0128385816075357 no 118 0.0120424489413918 149 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2903 5923464 63.88 µM 2.25497474515707 0.0128645691262044 no 119 0.0120674570164576 103 2876576 SGTC_303 1348-1668 34.2 µM 2.25476276663866 0.0128714842856501 no 120 0.012074111759651 119 5380509 SGTC_474 dl-dihydrosphingosine 5 µM 2.24091269060954 0.0133303234588077 no 121 0.0125158655240702 173 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1759 st043059 70 µM 2.23475007424378 0.0135389841258226 no 122 0.0127168805903498 164 669426 SGTC_3281 9140613 49.47 µM 2.22539769149775 0.0138610315606014 no 123 0.0130272761907983 137 16013766 SGTC_222 nsc-310342 10.666 µM 2.22143817353655 0.0139993545699918 no 124 0.0131606489570301 81 432556 SGTC_1847 st056231 15 µM 2.21143939818501 0.0143539620525193 no 125 0.0135027120556925 220 5393180 SGTC_108 0509-0257 621.132 µM 2.2025921300821 0.014674154423558 no 126 0.013811754553641 229 536624 SGTC_75 0159-0059 199.013 µM 2.20229516628313 0.0146850076187744 no 127 0.0138222327096663 160 5377270 SGTC_576 1073-0113 22.7 µM 2.20057303402008 0.0147480829709243 no 128 0.0138831321742707 278 5439563 SGTC_854 0422-0053 192 µM 2.18957269488815 0.0151565086924417 no 129 0.0142776205444487 150 3596728 SGTC_755 1995-0008 37.3 µM 2.18497306544712 0.0153301456451616 no 130 0.0144454107628938 159 689533 SGTC_90 0870-0863 4.608 µM 2.18147961192977 0.0154631631103295 no 131 0.0145739804194133 212 1738164 SGTC_2212 7123476 200 µM 2.17334738228042 0.0157766504451266 no 132 0.0148770909181914 92 1085715 SGTC_2726 cimetidine 79.27 µM 2.16202726993139 0.0162220916519021 no 133 0.015308037146004 103 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 2.14638260784285 0.0168554064955163 no 134 0.0159212328807078 222 442882 SGTC_7 0192-1582 4.227 µM 2.13975279514705 0.0171301015170829 no 135 0.0161873749581233 268 252616 SGTC_2952 9073731 13.78 µM 2.13624091386358 0.0172771540929558 no 136 0.0163298910869479 225 16457353 SGTC_1213 1315-0166 115 µM 2.13504009342587 0.0173276826889909 no 137 0.0163788676461782 174 768401 SGTC_3301 9125354 19.7965 µM 2.13078626632004 0.0175076936580325 no 138 0.0165533771456861 152 41905162 SGTC_2862 9027634 71.43 µM 2.13064016932789 0.0175139043578785 no 139 0.0165593988046252 187 5012562 SGTC_169 k015-0017 16.025 µM 2.1246333691412 0.0177708917218563 no 140 0.0168086086088711 155 1840002 SGTC_729 4092-0585 94.1 µM 2.11735276078091 0.0180866825126672 no 141 0.0171149601000681 186 2169061 SGTC_1533 dihydroergotamine mesylate 29.4 µM 2.10778302556153 0.0185090283843085 no 142 0.0175248808898338 184 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1313 1220-0047 237 µM 2.10093624767987 0.0188163291013993 no 143 0.0178232814845779 234 3528706 SGTC_51 1013-0126 23.419 µM 2.0967255137764 0.019007465029949 no 144 0.0180089403039271 176 1627850 SGTC_3222 9128301 49.47 µM 2.09420597084027 0.019122621200588 no 145 0.0181208180603415 188 4911358 SGTC_1740 st038286 13.222 µM 2.09216216821787 0.0192164688024674 no 146 0.018212005727839 216 716786 SGTC_3140 9094243 49.47 µM 2.09012276893061 0.0193105041458902 no 147 0.0183033864204732 214 19291112 SGTC_997 3996-0078 137 µM 2.08129328302656 0.0197221498598612 no 148 0.0187035348030519 218 735687 SGTC_1766 st045414 44.774 µM 2.07860245216206 0.019849072627167 no 149 0.0188269527083722 228 253960 SGTC_3172 9105863 49.47 µM 2.07363559275913 0.0200851735514905 no 150 0.0190565835034116 80 2348785 SGTC_976 1348-1067 47.6 µM 2.07283043259255 0.0201236705246864 no 151 0.0190940315750042 223 5310671 YGL099W LSG1 SGTC_1613 st002381 52.1 µM 2.05551323606602 0.0209669250395333 no 152 0.0199147292774062 201 551167 SGTC_636 0kpi-0074 126 µM 2.04842490709338 0.0213206150312212 no 153 0.0202591915450707 180 616434 SGTC_2365 9042475 200 µM 2.04206367838651 0.0216423072965312 no 154 0.0205726075996112 231 6464479 SGTC_3221 9128209 49.47 µM 2.04178683956254 0.0216563998768138 no 155 0.0205863401309623 176 16460723 SGTC_2320 7373003 200 µM 2.04075061489024 0.0217092181130062 no 156 0.0206378107872553 193 5415828 SGTC_1454 4239-0054 42.6 µM 2.03790757998827 0.021854691917193 no 157 0.020779588203257 242 1340767 SGTC_764 1951-2361 146 µM 2.03517722981334 0.0219951739286976 no 158 0.0209165216626728 220 5438930 SGTC_2463 5473429 200 µM 2.0326698790911 0.0221248529357356 no 159 0.0210429431878546 187 5399405 SGTC_2770 toltrazuril 17.5 µM 2.02448469837996 0.0225526867268483 no 160 0.0214601524078065 227 68591 Kills coccidiodes. SGTC_214 4373-3496 70 µM 2.02043696527495 0.0227668235610132 no 161 0.0216690411851692 336 3779166 SGTC_1294 1000-1494 117 µM 2.00487814447305 0.0236059477937597 no 162 0.0224880378670446 217 712797 YDL207W GLE1 SGTC_1193 1488-0126 41.5 µM 2.00241713098377 0.0237410298575501 no 163 0.022619943772516 233 1384710 SGTC_2639 lactacystin 53 µM 2.00234167299012 0.0237451819039919 no 164 0.0226239984695022 228 3870 A proteasome inhibitor. SGTC_1345 1488-0192 31.4 µM 2.00062106464217 0.0238400235113898 no 165 0.02271662088688 211 658348 SGTC_2652 actinonin 100 µM 1.99927000471139 0.023914718255282 no 166 0.0227895738812785 150 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.99561859827582 0.0241175747698464 no 167 0.0229877267815157 198 279621 SGTC_2674 ligustilide 100 µM 1.99132398702742 0.0243580129657077 no 168 0.0232226400022858 165 5319022 A signalling regulator. SGTC_3348 9149464 3.537 µM 1.97271621392367 0.0254231620822136 no 169 0.024263951815002 222 1951442 SGTC_2060 5238662 140 µM 1.97063120332211 0.0255449072827799 no 170 0.0243830374197462 226 790130 SGTC_1082 camptothecin 424.86 nM 1.97005526662236 0.0255786225428496 no 171 0.0244160184657593 245 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3123 9126162 49.47 µM 1.96265283927113 0.0260152865339246 no 172 0.024843263255324 213 25239884 SGTC_3324 9138759 60.749 µM 1.95512503074532 0.0264657240212804 no 173 0.0252841572546082 219 45595710 SGTC_3285 9112818 20.8695 µM 1.95291157154125 0.0265994029012661 no 174 0.0254150371538496 252 17017947 YPR165W RHO1 SGTC_2546 rhodinyl acetate 100 µM 1.94748221232311 0.0269296919701656 no 175 0.0257384751240004 227 6708682 SGTC_2487 5918373 44.05 µM 1.94395067056001 0.0271463617406109 no 176 0.0259507000096644 243 2876279 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.93309985141703 0.0278212082104565 no 177 0.0266119491980777 328 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2561 acetosyringone 100 µM 1.92541062084469 0.0283078402286616 no 178 0.0270890039610244 297 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2277 7947813 106.88 µM 1.91770517743209 0.0288025841603989 no 179 0.0275742024400817 259 1246798 SGTC_244 nsc-207895 1.295 µM 1.90836458191818 0.0294119340346464 no 180 0.0281720556161128 164 42640 SGTC_1596 piperlongumine 63 µM 1.90291353157953 0.0297724624481996 no 181 0.0285259145030613 245 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2317 5986382 200 µM 1.89948073587575 0.0300013809279956 no 182 0.0287506485663132 218 877883 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.88672227527612 0.0308650174870772 no 183 0.0295988449919571 267 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_342 k048-0088 23.3 µM 1.88208198790893 0.0311841846379946 no 184 0.0299124422781068 245 6820570 SGTC_1113 artemisinin 1.17947 µM 1.88136760072781 0.0312335631065156 no 185 0.0299609655009999 242 2240 An anti-malaria and mitochondrial poison. SGTC_1432 4049-0298 68.4 µM 1.86209447372227 0.0325903196066587 no 186 0.0312948874217674 226 741646 SGTC_540 1187-0821 17.3 µM 1.8601442906283 0.0327302731243696 no 187 0.0314325571745513 259 847520 SGTC_2727 riluzole 51.77 µM 1.85762582533108 0.0329117418287821 no 188 0.0316110842498871 206 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1629 st005085 44.9 µM 1.85598454902168 0.033030450157261 no 189 0.0317278802057761 287 24207091 SGTC_1658 st012944 20 µM 1.85530725484563 0.0330795394350788 no 190 0.0317761814038036 298 24207260 SGTC_1291 0993-0025 5.79 µM 1.85063443081939 0.033419859123436 no 191 0.0321110814417275 238 4353356 SGTC_1668 st014914 51.6 µM 1.84887394670594 0.0335488197458753 no 192 0.0322380082509201 233 2839556 SGTC_389 tpck 16.7 µM 1.84602824400668 0.0337581418228535 no 193 0.0324440522670858 259 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_368 fentichlor 4.58 µM 1.84087225288849 0.0341401393331298 no 194 0.0328201407172525 247 7329 A pesticide. SGTC_3346 9158254 43.5805 µM 1.8361731242178 0.0344913773899496 no 195 0.0331660280865697 279 17639500 SGTC_2841 9004761 38.96 µM 1.83109401643954 0.0348743501173278 no 196 0.0335432557404829 258 2991039 SGTC_1176 0848-0131 83.3 µM 1.82904879526906 0.0350295456707642 no 197 0.0336961493650655 299 6769040 SGTC_1868 st057644 42.7 µM 1.82856218580028 0.0350665539383631 no 198 0.0337326109273661 305 688665 SGTC_1153 4055-0057 267 µM 1.82017285700915 0.0357096506290765 no 199 0.0343663426175453 300 882706 SGTC_2345 9052315 157.45 µM 1.81619866933406 0.0360176547611472 no 200 0.034669951073449 286 6469265 SGTC_155 k072-0202 43.6 µM 1.81392644270801 0.0361947304080477 no 201 0.034844525548463 241 5857737 SGTC_1292 0kpi-0043 232 µM 1.81335136552481 0.036239659280434 no 202 0.0348888228040511 269 3333905 SGTC_44 0929-0055 61.211 µM 1.81223624713521 0.0363269098845412 no 203 0.034974850281495 266 1379590 SGTC_2690 usnic acid 100 µM 1.80797562301461 0.0366618602769968 no 204 0.0353051473233027 328 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1438 4092-1045 4 µM 1.8054751824514 0.0368596067868037 no 205 0.035500177819448 256 1351342 SGTC_1817 st052116 64.4 µM 1.79995008941794 0.037299650291204 no 206 0.035934259738287 267 4361398 SGTC_3303 9125618 40.5795 µM 1.79634520947946 0.0375890660805382 no 207 0.0362198159608733 359 22695467 SGTC_1479 0549-0158 134 µM 1.79421977985976 0.0377605625027785 no 208 0.0363890481212567 305 5440202 SGTC_1525 8-methoxypsoralen 92.5 µM 1.7934267900729 0.0378247105318686 no 209 0.0364523535367624 327 4114 Related to psoralen; DNA damaging agent. SGTC_1989 st071868 50.2 µM 1.79119259042501 0.0380059220235307 no 210 0.0366311974187462 288 16414057 SGTC_1975 st070967 30.8 µM 1.78502333818836 0.0385099782125224 no 211 0.037128765712716 330 261391 SGTC_2992 9074591 71.4286 µM 1.7796216855385 0.0389557793744734 no 212 0.0375689474042219 260 17741321 SGTC_188 3229-0966 278.469 µM 1.77565487297854 0.039285831383954 no 213 0.0378949098333428 352 5722370 SGTC_835 0312-0010 67.2 µM 1.77039268599636 0.0397271706454922 no 214 0.0383308736602624 255 1626196 SGTC_767 0929-0023 86 µM 1.765216875907 0.0401651895932821 no 215 0.0387636617084227 415 1204563 SGTC_1765 st044815 90.4 µM 1.76506438220816 0.0401781541052796 no 216 0.038776472962697 304 645695 SGTC_2222 6885208 172.143 µM 1.75985036150706 0.0406234820435466 no 217 0.0392165907650156 207 609514 SGTC_3013 9080133 71.4286 µM 1.75447834585116 0.0410864859979995 no 218 0.0396742885765033 340 17050193 SGTC_2267 7931562 200 µM 1.74706457788358 0.0417324831372284 no 219 0.0403130684616073 281 934880 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.74432150630635 0.0419735751551715 no 220 0.0405515217881171 329 5377381 SGTC_565 1418-0001 44.5 µM 1.74372108681472 0.0420264969054401 no 221 0.0406038682798609 355 2862145 SGTC_939 1165-0479 45.3 µM 1.73884726373131 0.0424580833727916 no 222 0.041030816236339 325 1377347 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.73382424552426 0.0429066251468005 no 223 0.0414746361707543 323 1377 SGTC_967 1306-0166 352 µM 1.72705521301278 0.0435171299861477 no 224 0.0420788740097663 334 4437607 SGTC_486 niguldipine 82 µM 1.72657331647845 0.0435608586441795 no 225 0.0421221607849549 261 1236 A calcium channel blocker. SGTC_2378 9074213 121.43 µM 1.72636844297146 0.0435794601876299 no 226 0.0421405746399589 336 657714 SGTC_2893 9048488 25.97 µM 1.72625324363469 0.0435899225569155 no 227 0.0421509315185285 288 6467338 SGTC_1970 st070122 35.8 µM 1.72557648777169 0.0436514262617619 no 228 0.042211816165134 342 102928 SGTC_109 0132-0036 33.701 µM 1.72196171239585 0.0439811246508454 no 229 0.0425382272491381 198 67274 A color developer. SGTC_2333 9017922 200 µM 1.72194503869657 0.0439826500746567 no 230 0.0425397375854327 314 3163164 SGTC_2762 leflunomide 42.06 µM 1.7195296316591 0.0442040791665361 no 231 0.0427589884451818 344 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_838 0109-0203 71.4 µM 1.70658813918877 0.0454058222963022 no 232 0.0439493156300146 308 759422 SGTC_48 0382-0018 55 µM 1.70278384380858 0.0457640427024997 no 233 0.0443042637088141 272 762596 SGTC_574 1315-0397 40 µM 1.70268296210666 0.0457735727611042 no 234 0.0443137075188954 416 6794277 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.6926603442792 0.0467283651101744 no 235 0.0452600688226539 347 5106787 A p450 inhibitor. SGTC_2019 4016004 108 µM 1.68928042041402 0.0470539289081669 no 236 0.0455828518637034 288 45595336 SGTC_1123 mangostin 811.285 nM 1.68888677841656 0.0470919635676873 no 237 0.045620564742026 369 5281650 An antioxidant. SGTC_329 k048-0121 21.3 µM 1.68822253559046 0.0471562002313107 no 238 0.0456842594110676 317 6832902 SGTC_3022 9087993 49.47 µM 1.68717106361469 0.0472580280901224 no 239 0.0457852318554144 269 17173644 SGTC_599 1935-0052 86.5 µM 1.68639701992393 0.0473331014807993 no 240 0.0458596775279071 349 9557311 SGTC_3067 9117431 49.47 µM 1.68364261725015 0.0476010224959015 no 241 0.0461253786395168 275 17150885 SGTC_1836 st055642 81 µM 1.67958133602075 0.0479982781609301 no 242 0.0465194007712128 354 8571 SGTC_2061 5245884 80.95 µM 1.67129558951655 0.0488169790523686 no 243 0.0473316535890532 359 573863 SGTC_2732 terfenadine 20 µM 1.67044942542136 0.048901211416196 no 244 0.0474152388632736 262 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2241 6772625 37.8075 µM 1.67014823103873 0.048931222163573 no 245 0.0474450197925511 336 2285411 SGTC_1061 3448-9325 110 µM 1.6676507289283 0.0491806383842459 no 246 0.0476925408228163 284 723482 SGTC_286 k060-0067 22.9 µM 1.66691150589434 0.049254656251459 no 247 0.0477660013359498 332 5985051 SGTC_3255 9139072 49.47 µM 1.66498646102182 0.0494478270924952 no 248 0.0479577284902579 328 17646060 SGTC_845 0330-0138 4.51 µM 1.66474269331098 0.0494723313221545 no 249 0.0479820507071526 331 9039800 SGTC_2621 lithochol-11-enic acid 100 µM 1.66158073159728 0.0497910598491964 no 250 0.0482984347088498 388 6708711 SGTC_1534 6-azauridine 81.6 µM 1.65912344601284 0.0500398858238305 no 251 0.0485454598155785 397 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1693 xanthone 101.9 µM 1.65208708976267 0.0507578782561489 no 252 0.049258399194275 354 7020 An insecticide. SGTC_1493 4348-0038 111 µM 1.65102722478224 0.0508667346902745 no 253 0.0493665079618853 373 800424 SGTC_2071 5230951 39.92 µM 1.64756886788868 0.0512232282321603 no 254 0.0497205866496362 357 1799272 SGTC_227 fluconazole 33.516 µM 1.64190627291529 0.051811227630656 no 255 0.0503047148320645 431 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2904 7225135 42.03 µM 1.64026630679888 0.0519825185301044 no 256 0.050474903972782 341 4446116 SGTC_2788 5282734 71.43 µM 1.6352700812079 0.0525071380489331 no 257 0.0509962212909964 409 743706 SGTC_872 0588-0139 234 µM 1.6351355029861 0.0525213271010952 no 258 0.0510103225345265 375 2047100 SGTC_3051 9093778 49.47 µM 1.6293090111033 0.05313855803469 no 259 0.0516238097562171 262 17217378 SGTC_2885 9057732 51.95 µM 1.62765344482875 0.0533149861482074 no 260 0.0517991949197119 344 6471414 SGTC_1778 st046819 58.9 µM 1.62337087560256 0.053773519283353 no 261 0.052255073373498 410 671715 SGTC_2988 9073640 71.4286 µM 1.62224005006673 0.0538951161076506 no 262 0.0523759796869117 342 9102229 SGTC_3017 9080681 49.47 µM 1.62199112160118 0.0539219124138019 no 263 0.052402624581307 328 16451914 SGTC_737 1950-0117 57.9 µM 1.62103985072588 0.0540244106877662 no 264 0.052504546207405 358 5393513 SGTC_2133 5320837 200 µM 1.61997720066934 0.0541390922369993 no 265 0.0526185872860966 358 2841355 SGTC_384 k007-0144 5.16 µM 1.61597487440112 0.0545727548275869 no 266 0.0530498728171097 428 6824886 SGTC_3243 9134147 49.47 µM 1.61322243399726 0.0548725798305727 no 267 0.0533480955949029 314 24282180 SGTC_3275 9138069 49.47 µM 1.61246624054541 0.0549551800107854 no 268 0.0534302602570672 323 17617007 SGTC_984 1492-0255 2.91 µM 1.61010187812911 0.0552140769919704 no 269 0.0536878085767681 336 1585198 SGTC_612 0302-0167 22.4 µM 1.60070961107907 0.0562520539689847 no 270 0.0547206257192253 448 235821 SGTC_1618 st003135 44.5 µM 1.59821996770026 0.0565297580574217 no 271 0.0549970156940865 318 1270615 SGTC_3066 9117245 49.47 µM 1.59480459631224 0.0569124775048131 no 272 0.0553779694546316 370 17176980 SGTC_1926 methyl fluorone black 53.6 µM 1.59458859572893 0.0569367505171447 no 273 0.0554021322474039 360 72721 Reacts with homocysteine. SGTC_802 4112-3352 742 µM 1.58877234447354 0.0575934203615094 no 274 0.0560558995539669 413 704594 SGTC_1325 1431-0015 227 µM 1.58457074991658 0.0580714860231256 no 275 0.0565319475457978 342 1103340 SGTC_134 0269-0018 6.916 µM 1.57670446789538 0.0589749057962324 no 276 0.0574317709353934 467 4378915 SGTC_913 3487-1245 167 µM 1.57176688368166 0.0595475820810332 no 277 0.0580023121741312 394 4016153 SGTC_2810 7959871 45.46 µM 1.5709060577488 0.0596478680145424 no 278 0.0581022356523724 454 2974535 SGTC_2423 st077119 87.2 µM 1.57053002498034 0.0596917172185856 no 279 0.0581459274410559 380 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2227 7312221 64.1025 µM 1.57048410941393 0.0596970731654628 no 280 0.0581512642048587 308 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1865 st057639 52.2 µM 1.55916020752704 0.0610295171149093 no 281 0.0594792332163937 406 688818 SGTC_1862 st057513 3.81 µM 1.55890558644652 0.0610597425633282 no 282 0.0595093639639839 368 5393163 SGTC_2301 7769476 200 µM 1.55876246443644 0.0610767373647626 no 283 0.0595263056496518 344 977820 SGTC_117 lucigenin 22.078 µM 1.55855434954143 0.0611014562420959 no 284 0.0595509474391455 465 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2516 gossypol 71.55 µM 1.55516512358858 0.0615051135070671 no 285 0.0599533740996789 407 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2105 5350118 200 µM 1.55013498510473 0.0621080393495685 no 286 0.0605545602691408 378 2133313 SGTC_130 0136-0219 337.655 µM 1.54980787901363 0.0621474062789156 no 287 0.060593817682777 392 234244 SGTC_2214 7179297 48.276 µM 1.54650609541033 0.0625458637271051 no 288 0.0609911945666605 329 769744 SGTC_1653 st012112 65 µM 1.54438909919345 0.0628023876728265 no 289 0.0612470496164009 364 720429 SGTC_1504 k297-0033 30 µM 1.54128494894447 0.0631800100171424 no 290 0.0616237251881825 324 4388117 SGTC_1403 3909-7815 62.9 µM 1.5407805066469 0.0632415424866691 no 291 0.0616851076407242 336 6615483 SGTC_652 0437-0092 114 µM 1.54066064051428 0.0632561707584749 no 292 0.0616997004236052 352 3091274 SGTC_472 calcifediol 10 µM 1.53843358046657 0.0635284370643692 no 293 0.0619713184399625 318 5283731 A vitamin D metabolite. SGTC_2130 NSC 7 2.4545 µM 1.5351004892005 0.0639376225012756 no 294 0.0623795730801843 425 21448 SGTC_3023 9089636 49.47 µM 1.528319645788 0.064776392902499 no 295 0.0632165972532179 393 17249241 SGTC_2118 5526350 200 µM 1.5271103088747 0.0649268780989167 no 296 0.0633667919611057 419 743594 SGTC_2090 5301565 104.445 µM 1.51921322666591 0.0659162418527985 no 297 0.0643544165364087 467 2056344 SGTC_2315 7733312 200 µM 1.51611344262365 0.0663077674221634 no 298 0.0647453348862264 370 726316 SGTC_317 4495-0002 170 µM 1.51417714140683 0.0665532488589091 no 299 0.0649904588075954 360 15991618 SGTC_2635 hydroquinidine 100 µM 1.51334666784495 0.0666587504015124 no 300 0.0650958121689754 414 442912 An experimental heart treatment. SGTC_2883 9059145 45.46 µM 1.50587109216546 0.0676142661160763 no 301 0.0660501343865888 364 16476510 SGTC_572 0960-0087 17.7 µM 1.50572557846249 0.0676329698889552 no 302 0.0660688174500326 495 6796365 SGTC_3098 9119039 49.47 µM 1.50468036401037 0.0677674352417521 no 303 0.0662031368966368 420 17161528 SGTC_14 0354-0009 295 µM 1.50022297282446 0.06834319141025 no 304 0.0667783271938437 423 1713507 SGTC_3273 9137859 49.47 µM 1.50011124545092 0.0683576714503392 no 305 0.0667927942276273 357 2377234 SGTC_1956 st077085 54 µM 1.49991136184635 0.0683835825798246 no 306 0.0668186822326092 473 24208685 SGTC_305 1682-2595 20.8 µM 1.49853547855366 0.0685621454931931 no 307 0.0669970909943634 418 226033 SGTC_728 3030-5151 22.5 µM 1.49725236263989 0.0687289928936106 no 308 0.0671638025587585 384 3125388 SGTC_1398 3558-0053 112 µM 1.49704115005175 0.0687564874837651 no 309 0.0671912755233978 341 4532369 SGTC_2725 haloperidol 53.21 µM 1.49172941952921 0.0694507339336559 no 310 0.0678850466981491 430 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2513 baicalein 25.65 µM 1.48595679889784 0.070211327166633 no 311 0.0686452741693813 415 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2235 salicylic acid 500 µM 1.48269843050559 0.0706434653499736 no 312 0.0690772759115718 381 338 A COX inhibitor and kinase inhibitor. SGTC_1899 st063254 59.6 µM 1.48222685317419 0.070706176833627 no 313 0.0691399718605376 367 3093813 SGTC_2587 piperic acid 92.2 µM 1.47232951630144 0.0720322411965896 no 314 0.0704659582047574 408 5370536 SGTC_331 k048-0133 24.5 µM 1.46545614322403 0.0729643101074699 no 315 0.071398254729946 386 6813582 SGTC_681 1642-0006 26.6 µM 1.46523883187986 0.0729939286151245 no 316 0.0714278842430954 373 4446530 SGTC_1729 st035615 45.989 µM 1.4571783843329 0.0740990424497965 no 317 0.072533572859793 444 17385451 SGTC_2658 polymyxin b sulfate 77.05 µM 1.45558337748813 0.0743192301193282 no 318 0.0727539129587643 464 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_96 0929-0093 37.281 µM 1.4546697710729 0.0744455766082427 no 319 0.0728803525548548 432 6991579 SGTC_2889 9059656 51.95 µM 1.45389537517268 0.074552799438227 no 320 0.0729876576179878 475 3949838 SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.44818953429251 0.0753464671247947 no 321 0.0737820253628197 399 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.44666491774811 0.0755596238283978 no 322 0.0739953973362344 333 279621 SGTC_1562 morin hydrate 59.1 µM 1.44483311640349 0.0758163353620562 no 323 0.0742523833370925 441 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_143 4032-1194 15.74 µM 1.43672556714422 0.0769605219763763 no 324 0.075397993619171 555 1806963 SGTC_2428 5615643 7.78 µM 1.43567124398841 0.0771102737730824 no 325 0.0755479557599577 457 2253075 SGTC_763 3453-1109 128 µM 1.43384159798314 0.0773706746943439 no 326 0.075808735569079 468 1560353 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.43366007365745 0.0773965461796149 no 327 0.0758346456057323 733 16725076 SGTC_2706 st078239 82.5 µM 1.43105661695804 0.0777683232451971 no 328 0.0762069947186975 448 15434492 SGTC_3078 9116413 49.47 µM 1.43083466985347 0.0778000801836592 no 329 0.0762388020827681 423 17177322 SGTC_159 3970-0959 50 µM 1.42952453725476 0.0779877389255574 no 330 0.0764267638025303 675 6615653 SGTC_2243 6634756 200 µM 1.42914299361585 0.0780424544037188 no 331 0.0764815692282485 411 885676 SGTC_1670 st016595 4.04 µM 1.4283177955105 0.0781608920013272 no 332 0.0766002040098099 477 597879 SGTC_866 0495-0101 262 µM 1.42786675192954 0.0782256861993431 no 333 0.0766651075175842 430 635694 SGTC_600 1495-0418 41.6 µM 1.42761539139175 0.078261812809752 no 334 0.0767012955149611 448 5377768 SGTC_1611 st001856 99.4 µM 1.42511852656926 0.0786213602678319 no 335 0.0770614710599388 448 647478 SGTC_2465 5809242 33.21 µM 1.41869467765348 0.0795521443727402 no 336 0.0779940247886567 414 2731748 SGTC_2958 9077254 16.72 µM 1.41759918402686 0.0797117048362375 no 337 0.0781539092599271 428 16457351 SGTC_1644 st010134 20.9 µM 1.41670731279697 0.0798417860458765 no 338 0.078284259058685 449 3818134 SGTC_126 0417-1624 672.48 µM 1.41588694090518 0.0799615806318396 no 339 0.078404304516151 587 41912 YDL195W SEC31 SGTC_1205 4161-2785 76 µM 1.41470304801943 0.0801346977939228 no 340 0.0785777901697763 426 3498106 SGTC_2733 amorolfine 100 µM 1.41091066443155 0.0806911543419078 no 341 0.0791354786194686 330 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_20 0481-0013 4.944 µM 1.40898212033224 0.0809752465817341 no 342 0.0794202275509233 480 182045 SGTC_875 0709-0210 25.7 µM 1.40444976773106 0.0816458749469282 no 343 0.0800924799424882 526 6251364 SGTC_1671 st016596 74.5 µM 1.40326826532946 0.0818213818006591 no 344 0.0802684288374629 506 2829167 SGTC_1605 st000082 49.1 µM 1.40179344892641 0.0820408579425867 no 345 0.080488467647568 444 1114022 SGTC_2955 9076254 12.21 µM 1.39898134512014 0.0824605724499887 no 346 0.0809092886287091 432 16459619 SGTC_121 0557-0495 61.343 µM 1.39882308140181 0.0824842417227009 no 347 0.0809330214869517 650 3104427 SGTC_1771 st048882 4.1505 µM 1.39587939147223 0.0829254207270074 no 348 0.0813754087783113 460 4580403 SGTC_904 1141-0088 396 µM 1.39582764441815 0.0829331920477238 no 349 0.0813832017748417 473 1378119 SGTC_1843 st055809 45.5 µM 1.39547525851379 0.082986127578469 no 350 0.0814362853137786 460 16413835 SGTC_1484 3473-2379 286 µM 1.39202823501541 0.083505281550712 no 351 0.0819569240263118 580 671917 SGTC_1776 st049249 45.9 µM 1.39071958989359 0.0837030136516886 no 352 0.0821552373998674 506 1822314 SGTC_2146 5545642 200 µM 1.39045818625653 0.0837425530202405 no 353 0.0821948940421331 471 825326 SGTC_1578 josamycin 24.2 µM 1.38938840737266 0.0839045117500664 no 354 0.0823573367513972 435 5282165 A P450 substrate. SGTC_2179 6298986 200 µM 1.38778190346947 0.0841481694428193 no 355 0.0826017334717063 438 738374 SGTC_100 0086-0128 49.5915 µM 1.38748290667444 0.0841935767152933 no 356 0.082647279912346 550 93297 SGTC_2066 5222451 176 µM 1.3867137938559 0.0843104628508325 no 357 0.0827645263752546 557 2281147 SGTC_463 ikarugamyin 104 µM 1.38624382716099 0.0843819460874356 no 358 0.0828362314526521 375 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_520 3584-0023 682 µM 1.38311386497486 0.0848591824394864 no 359 0.0833149775028523 480 1340790 SGTC_3004 9076122 71.4286 µM 1.38219244362193 0.0850000596222404 no 360 0.0834563098308308 505 44782551 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.38114448351036 0.0851604964460593 no 361 0.0836172702416897 477 521171 SGTC_2878 9043973 25.97 µM 1.3785551683758 0.0855578789461905 no 362 0.0840159735855136 457 6465167 SGTC_1273 0849-0096 14.1 µM 1.3778208444704 0.0856708280632183 no 363 0.0841293043447162 497 5286025 SGTC_3267 9137951 49.47 µM 1.37488053514212 0.0861242066436971 no 364 0.0845842423906021 414 16643986 SGTC_2784 7567673 72.73 µM 1.37344900650532 0.0863455886277202 no 365 0.0848064018174413 534 3471247 SGTC_1846 st056244 14.8 µM 1.37142074817723 0.0866599814442596 no 366 0.0851219166233553 529 5393182 SGTC_2119 5528445 120.635 µM 1.37024272491335 0.086842974808339 no 367 0.0853055726899738 477 791935 SGTC_3000 9075062 71.4286 µM 1.36929094216237 0.0869910348621776 no 368 0.0854541741142316 474 17057871 SGTC_3005 9076496 71.4286 µM 1.36801707418819 0.0871894936977561 no 369 0.085653365844308 454 21368410 SGTC_1296 1068-0102 11.9 µM 1.36243729925872 0.0880627645308661 no 370 0.0865299596056409 503 767053 SGTC_2824 7998404 51.95 µM 1.36055389120626 0.0883589973149809 no 371 0.0868273556322791 472 837851 SGTC_2520 obtusaquinone 4.71 µM 1.35757462226443 0.0888291085503165 no 372 0.0872993500605321 496 5967872 SGTC_3092 9117248 49.47 µM 1.35587672361326 0.0890978588230119 no 373 0.0875691972867109 514 17141857 SGTC_4 0960-0234 25.671 µM 1.35315460845223 0.089529988300449 no 374 0.0880031214889227 466 6821112 SGTC_390 dec-rvkr-cmk 16.7 µM 1.35290353752158 0.0895699236031538 no 375 0.0880432245683177 534 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1915 st067105 30.6 µM 1.34886418774977 0.0902142439995167 no 376 0.0886902964788306 517 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2617 dihydrotanshinone i 20.83 µM 1.34840424272958 0.0902878280255918 no 377 0.0887642000618713 556 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1678 st019265 80.2 µM 1.34485647544435 0.0908569140248033 no 378 0.0893357940807894 554 5367020 SGTC_2029 5175081 200 µM 1.34382863823649 0.0910222822693532 no 379 0.0895019032341496 563 1380876 SGTC_1382 3002-2117 298 µM 1.34304822897663 0.0911479909807105 no 380 0.0896281787999417 530 1497314 SGTC_1216 1165-0504 9.65 µM 1.34130547894903 0.091429178725908 no 381 0.0899106458296456 533 6304004 SGTC_1181 1222-0449 220 µM 1.33976217473208 0.0916787228238502 no 382 0.0901613383244523 509 658318 SGTC_391 gliotoxin 8.33 µM 1.33672792216319 0.092170816112476 no 383 0.0906557320761764 557 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1169 aniline yellow 25.8 µM 1.33345093178348 0.0927044697336257 no 384 0.091191933907349 480 6051 A DNA damaging agent. SGTC_570 0987-0065 62.6 µM 1.33172209470841 0.0929869277482357 no 385 0.0914757630385186 407 3104428 SGTC_1848 st056003 16.4 µM 1.33168317804957 0.0929932932791756 no 386 0.0914821596469519 549 146492 SGTC_53 0973-0023 39.979 µM 1.32641432113839 0.093858087995445 no 387 0.0923512488558582 498 674768 SGTC_1612 st002233 45.4 µM 1.32576903165671 0.0939644081475169 no 388 0.0924581068652079 520 1035021 SGTC_1303 1160-0052 261 µM 1.32448390933545 0.0941764141075843 no 389 0.0926711917532771 523 3562476 SGTC_2778 tioconazole 65.09 nM 1.32382091638196 0.0942859255916758 no 390 0.0927812639006782 559 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2586 curcumin 80 µM 1.32292900565425 0.0944333972559767 no 391 0.0929294941634871 614 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1659 st012954 42.1 µM 1.32236794255275 0.0945262525124829 no 392 0.0930228291813796 505 24207262 SGTC_1699 st031318 29.054 µM 1.32187065953716 0.0946086084975971 no 393 0.0931056120437117 515 5340658 SGTC_3115 9123671 49.47 µM 1.32033314634656 0.0948635735364772 no 394 0.0933619067554643 518 3286988 SGTC_2945 9067681 61.76 µM 1.31580329916269 0.0956176983901209 no 395 0.0941200358351137 494 16456930 SGTC_1802 st050112 57.9 µM 1.31504164888312 0.0957449292630268 no 396 0.0942479527360312 539 4662563 SGTC_479 n-linoleoylglycine 10 µM 1.31364691873462 0.0959782365750083 no 397 0.0944825258465384 492 6433346 An anti-infammatory. SGTC_935 2996-0153 430 µM 1.31184263721946 0.0962806726052088 no 398 0.0947866177220532 529 23738523 SGTC_3112 9123419 49.47 µM 1.31026188024844 0.0965462163181738 no 399 0.0950536291973046 566 17015854 SGTC_1483 3453-0561 55.9 µM 1.30965023525825 0.0966491078390616 no 400 0.0951570929229222 597 4546991 SGTC_1436 4092-1007 8.32 µM 1.30960242800769 0.0966571534141275 no 401 0.0951651833232641 511 2881121 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.30929961712198 0.0967081254728047 no 402 0.0952164396444371 485 364106 SGTC_1959 st077091 55.8 µM 1.3073194020723 0.0970419411833159 no 403 0.0955521287415392 558 821356 YKL052C ASK1 SGTC_1927 st060202 13.8 µM 1.29362757863532 0.099373213619007 no 404 0.0978970458232354 525 688887 SGTC_128 0906-2981 13.371 µM 1.29258190180249 0.0995529269089471 no 405 0.0980778512032948 489 6740226 SGTC_27 0485-0001 32.618 µM 1.29181337584258 0.0996851595330766 no 406 0.0982108910199504 429 2054479 SGTC_1272 0839-0021 27 µM 1.28956469204266 0.10007280519873 no 407 0.0986009207090571 574 5027250 SGTC_793 0488-0545 106 µM 1.28936415920164 0.100107427994306 no 408 0.0986357577161638 558 292548 SGTC_611 3453-1652 23.7 µM 1.28817539901286 0.100312851786803 no 409 0.0988424567761114 582 1560575 SGTC_2439 5492030 7.2 µM 1.28785049012523 0.100369051188615 no 410 0.0988990063458647 538 5722370 SGTC_1107 amlodipine 47 µM 1.28715611714923 0.100489233709708 no 411 0.0990199395482919 571 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_348 k064-0012 10.7 µM 1.28646844886298 0.100608359225725 no 412 0.0991398116234079 519 5066323 SGTC_452 diindolylmethane 8 µM 1.2842208731209 0.100998427695203 no 413 0.0995323418802134 489 3071 Inhibits expression of several cancer promoting factors. SGTC_411 enrofloxacin 100 µM 1.28328150096457 0.101161782699302 no 414 0.0996967356637407 542 71188 A bacterial gyrase inhibitor. SGTC_2021 4019055 173 µM 1.27913758120627 0.101884700683638 no 415 0.100424305800351 728 44827708 YER133W GLC7 SGTC_183 3914-0051 30.55 µM 1.27761141387668 0.102151889858508 no 416 0.100693237033649 557 1596232 SGTC_1256 0570-0116 285 µM 1.2772674830318 0.10221217283916 no 417 0.100753914736835 532 410638 SGTC_1397 3532-0190 20.1 µM 1.27595438111695 0.102442566693885 no 418 0.1009858228588 468 5322280 SGTC_1697 st025554 27.742 µM 1.27486189312374 0.102634539725787 no 419 0.101179064508472 529 1269519 SGTC_816 0325-0417 81.3 µM 1.27235034096024 0.103076863360959 no 420 0.101624334843626 524 68101 SGTC_2072 5231554 129 µM 1.27103522416624 0.103309027561177 no 421 0.101858058859992 561 789545 SGTC_3228 9131799 49.47 µM 1.26472570731592 0.104428159164681 no 422 0.102984835630716 555 17015818 SGTC_1018 4259-0013 28.1 µM 1.26439598559567 0.104486883153925 no 423 0.10304396651881 555 6801262 SGTC_956 1185-0240 191 µM 1.25803119353291 0.105625155344428 no 424 0.104190237635881 565 1416193 SGTC_3321 9137793 26.8275 µM 1.25682767647713 0.105841395181747 no 425 0.104408020937425 608 4904192 SGTC_2211 7117706 200 µM 1.25640214712308 0.105917927945415 no 426 0.104485101788559 540 822771 SGTC_798 1287-0182 476 µM 1.25613086847159 0.105966739116366 no 427 0.104534263014696 638 1649755 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.25125263964375 0.106847254704972 no 428 0.10542115927028 561 229346 A bile salt which induces apoptosis. SGTC_94 0334-0113 514.748 µM 1.25117325078748 0.106861627840484 no 429 0.105435637593189 571 6795178 SGTC_809 3998-0021 90 µM 1.24630638929603 0.10774542564457 no 430 0.10632596654256 551 715485 SGTC_665 3914-0008 307 µM 1.24467321313634 0.108043178992709 no 431 0.106625948121016 582 1069549 SGTC_1789 tunicamycin 25 nM 1.24149305806373 0.108624669625278 no 432 0.107211830525861 574 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3268 9137683 49.47 µM 1.23815370717852 0.109237688408779 no 433 0.107829536409463 538 1953228 SGTC_1249 0481-0015 10.2 µM 1.23583978766476 0.109663919799133 no 434 0.108259061102955 529 4227577 SGTC_724 3910-0327 137 µM 1.23461651199234 0.109889732959353 no 435 0.108486630384325 604 2885483 SGTC_1135 dihydrocapsaicin 536.708 nM 1.23107305396519 0.110545727881147 no 436 0.109147771286624 590 107982 A Capsaicinoid. SGTC_1616 st002734 56.1 µM 1.23082420429074 0.11059190230354 no 437 0.109194310404401 622 4026101 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.22130277480161 0.112369012437184 no 438 0.110985701598579 645 688801 SGTC_3239 9133757 49.47 µM 1.22027061663213 0.112562876652926 no 439 0.111181152383781 594 17036923 SGTC_2422 chlorphenesin carbamate 384.24 µM 1.21627901518684 0.113314843815691 no 440 0.111939326314059 641 2724 A muscle relaxant with antifungal properties. SGTC_1006 4099-6547 255 µM 1.21537948245557 0.113484798002634 no 441 0.112110694871322 613 3146833 SGTC_1979 st071809 45.3 µM 1.21210416858114 0.114105158626394 no 442 0.112736254122665 621 4976333 SGTC_2170 morpholine 200 µM 1.20904443116257 0.114686866843432 no 443 0.113322888031715 627 121171 Reacts with secondary amines. SGTC_2801 7907800 81.82 µM 1.20712745504564 0.115052390132009 no 444 0.113691531511885 636 6620925 SGTC_1444 4112-3581 28 µM 1.20669211323605 0.115135515112682 no 445 0.113775368755942 614 2877249 SGTC_1305 1181-0477 144 µM 1.20457670161315 0.115540043639754 no 446 0.114183377694536 600 6252086 SGTC_2484 5809818 12.04 µM 1.20319528216419 0.115804755852119 no 447 0.114450380081288 598 2870548 SGTC_369 0957-0393 4.5 µM 1.20307728820389 0.115827386198045 no 448 0.114473206679539 564 6997992 SGTC_287 k060-0039 29.6 µM 1.20103977137581 0.116218661874443 no 449 0.114867887067711 599 5861974 SGTC_1300 1094-0077 113 µM 1.20061230390807 0.116300869723011 no 450 0.114950813020162 582 5532636 SGTC_2259 7964009 200 µM 1.20056128855786 0.116310683428699 no 451 0.114960712514819 576 313134 SGTC_3161 9100388 49.47 µM 1.20021872615388 0.116376596590263 no 452 0.115027202226664 617 25236368 SGTC_8 0354-0001 70 µM 1.19932234236195 0.116549197084991 no 453 0.115201315393955 734 4993152 SGTC_3242 9133940 49.47 µM 1.19575187940946 0.117238498450094 no 454 0.115896699717565 625 17248444 SGTC_2475 5812728 15.03 µM 1.19439789051059 0.117500648599797 no 455 0.11616118080981 646 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_890 0929-0006 47.2 µM 1.19296796447941 0.117777951480341 no 456 0.116440959817354 597 1378169 SGTC_3034 9090421 49.47 µM 1.19230373559144 0.117906921553976 no 457 0.116571085157384 568 17173761 SGTC_3025 9087895 49.47 µM 1.19030900705236 0.118294828709759 no 458 0.1169624809677 681 17173641 SGTC_1420 4'-methoxyflavone 42 µM 1.18681608688261 0.11897625496165 no 459 0.117650086007303 628 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_69 0096-0274 206.684 µM 1.18469796666245 0.119390822036721 no 460 0.118068443354601 705 6741392 SGTC_1837 st055472 66.5 µM 1.18400485740506 0.11952670127298 no 461 0.118205570009436 633 676091 SGTC_1860 st056228 74.6 µM 1.18327604350406 0.11966969778502 no 462 0.11834988199715 605 688679 SGTC_784 4579-0127 173 µM 1.18108638564014 0.120100043988831 no 463 0.118784203877177 663 1948547 SGTC_2703 st077852 53.4 µM 1.17527234847776 0.121247999392004 no 464 0.119942886740036 611 6281836 SGTC_1480 1070-0044 41.2 µM 1.17141895672413 0.122013073388228 no 465 0.120715208077812 650 3124987 SGTC_2471 5466956 24.79 µM 1.17111730189842 0.122073108404638 no 466 0.120775815075227 628 724419 SGTC_1137 ixabepilone 100 µM 1.17005018851415 0.122285650625094 no 467 0.120990386108778 690 154225 A novel microtubule stabilizer. SGTC_1327 1436-0082 2.18 µM 1.16890915714941 0.122513202685623 no 468 0.121220116859113 631 15992205 SGTC_3085 9117376 49.47 µM 1.16796011210974 0.122702693757366 no 469 0.121411427402707 646 16480349 SGTC_3306 9127676 59.7925 µM 1.16226794311891 0.123843534856367 no 470 0.122563321892912 617 41905287 SGTC_3343 9148379 18.9835 µM 1.16082277804979 0.124134357118784 no 471 0.122856988905012 655 1955036 SGTC_480 am 92016 50 µM 1.15647682566588 0.125011805940698 no 472 0.123743086643718 597 2129 K+ channel blocker. SGTC_2835 9006588 71.43 µM 1.15407058252602 0.125499486123018 no 473 0.124235616376004 636 2345538 SGTC_2656 pseudo-anisatin 100 µM 1.15315848124616 0.125684690870879 no 474 0.124422670736145 631 6708809 A neurotoxin. SGTC_2223 6903751 107.57 µM 1.15162988360946 0.125995504341973 no 475 0.124736598007639 613 5598863 SGTC_1481 3346-2004 36 µM 1.14658273923426 0.127025556987179 no 476 0.125777056800161 674 2770522 SGTC_2581 avocatin a 64 µM 1.14140008574847 0.128089348969771 no 477 0.126851734516018 697 6710728 A skin care supplement. SGTC_9 0092-0002 10.449 µM 1.14137087475605 0.128095362306488 no 478 0.126857809784305 683 759368 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.13822342195782 0.128744441962037 no 479 0.127513600423072 658 6710655 SGTC_1728 st035614 33.7865 µM 1.13737903904785 0.128918961331617 no 480 0.127689932978565 741 15945546 SGTC_2462 5162487 171.77 µM 1.13504513375933 0.129402192529389 no 481 0.12817820409262 695 2259986 SGTC_1516 st013856 110 µM 1.13465459802526 0.129483174727456 no 482 0.128260033675993 639 5281404 A mutagen and neurotoxin. SGTC_3097 9117246 49.47 µM 1.13338810978377 0.129746037573526 no 483 0.128525652544329 663 16423892 SGTC_1143 3454-2408 5.08 µM 1.13209947589821 0.130013875870349 no 484 0.128796307604396 631 X1143 SGTC_1254 0550-0035 264 µM 1.13201404004125 0.130031646949045 no 485 0.12881426588096 719 15121435 SGTC_341 1486-1430 230 µM 1.12786415930581 0.13089686731733 no 486 0.129688646135837 664 2054753 YPL210C SRP72 SGTC_3079 9117512 49.47 µM 1.12678130084461 0.131123288562867 no 487 0.129917479199528 732 7185044 SGTC_549 1661-1316 519 µM 1.12485852058019 0.131526000390703 no 488 0.130324495707321 699 2857282 SGTC_1242 0402-0103 60.1 µM 1.1241386189153 0.13167699779902 no 489 0.130477112107074 634 432868 SGTC_2510 benzyl isothiocyanate 8.31 µM 1.12299548149474 0.131917013462916 no 490 0.130719706748329 636 2346 DNA damaging agent; causes G2/M arrest. SGTC_631 k072-0230 41.5 µM 1.12275239381425 0.131968091574369 no 491 0.130771334571237 734 5773147 SGTC_2196 6573537 42.6665 µM 1.12256785223032 0.132006876960016 no 492 0.130810537576804 674 2903087 SGTC_546 peri-Naphthalide 147 µM 1.1180507442558 0.132958696234297 no 493 0.131772660730828 690 223824 A penicillin ester. SGTC_165 k038-0023 64.381 µM 1.11511418091275 0.133580000402756 no 494 0.132400747675142 689 46368543 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.11501105208632 0.133601856140115 no 495 0.132422842824454 772 688788 SGTC_2371 9071574 200 µM 1.11315722247979 0.133995151279621 no 496 0.132820455599593 632 45596039 SGTC_840 0245-0196 390 µM 1.11232710790213 0.134171520030826 no 497 0.132998766319722 750 3827528 SGTC_2429 5902844 64.44 µM 1.10990702829028 0.134686607568692 no 498 0.13351954579004 727 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2024 5144227 134 µM 1.10934496732235 0.134806430039213 no 499 0.133640696689331 746 3475211 SGTC_3055 9094636 49.47 µM 1.10933144298153 0.134809314114673 no 500 0.133643612759642 658 25236176 SGTC_2923 7992654 58.14 µM 1.10800194629402 0.135093036894205 no 501 0.133930487674184 675 2985126 SGTC_207 4185-0010 4.486 µM 1.10739409418614 0.135222892586039 no 502 0.134061789098234 798 3761753 SGTC_1089 terbinafine 2.25 µM 1.10487404841105 0.135762163633826 no 503 0.134607084450786 688 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2201 6605497 169.863 µM 1.10186429072633 0.136408157138551 no 504 0.135260337542868 693 670741 SGTC_1763 st044482 94.5 µM 1.09842965539931 0.137147908572046 no 505 0.136008459436523 732 88505 SGTC_2853 9015042 58.44 µM 1.09761683479457 0.137323374074335 no 506 0.136185919284703 652 6457456 SGTC_2787 5284540 71.43 µM 1.09668713864979 0.137524257657988 no 507 0.136389090295041 699 736958 SGTC_2453 5731132 22.18 µM 1.09317227022626 0.13828554325436 no 508 0.137159084825121 756 1362040 SGTC_3156 9099931 49.47 µM 1.0926661475103 0.138395400570667 no 509 0.13727020412878 738 18111053 SGTC_3122 9126309 49.47 µM 1.09230840379003 0.138473087105996 no 510 0.137348783884777 694 17591206 SGTC_947 3447-0010 211 µM 1.08915157423542 0.139159902674819 no 511 0.138043524866914 703 748350 SGTC_2783 7738165 71.43 µM 1.08644204974489 0.139751246311529 no 512 0.138641733157014 612 17201110 SGTC_2533 agelasine 13.65 µM 1.08624395015728 0.139794547724942 no 513 0.138685538718429 746 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_787 4152-0075 138 µM 1.08167133425423 0.140796583947303 no 514 0.139699297494036 695 9566539 SGTC_524 r073-0010 27.8 µM 1.07929952865687 0.141318252759962 no 515 0.140227111479692 706 2772106 SGTC_1437 4092-1038 11.6 µM 1.07149240284352 0.143044643046392 no 516 0.141974042428991 767 3977136 SGTC_1835 st008666 49.2 µM 1.07119843905503 0.14310992446536 no 517 0.142040106665767 624 690455 SGTC_1750 st081859 2.357 µM 1.06857689666988 0.143692988264705 no 518 0.142630181766077 890 5291695 SGTC_1929 genistein trimethyl ether 50.5 µM 1.068509707484 0.143707953019048 no 519 0.142645326931739 736 136420 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.06646204261698 0.144164524925597 no 520 0.143107414205771 741 5379071 SGTC_1384 3089-0840 101 µM 1.06437558633119 0.144630751162272 no 521 0.143579294441263 697 1069836 SGTC_2563 tomatine 8.54 µM 1.06179073098668 0.145209753599444 no 522 0.144165349315785 793 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2942 9052777 62.25 µM 1.05757561313105 0.146157272885884 no 523 0.145124482723297 816 6469503 SGTC_1344 1488-0097 29.1 µM 1.05560176505398 0.146602400081794 no 524 0.145575097090363 724 747966 SGTC_88 0180-0332 8.668 µM 1.04980550659281 0.147914782053087 no 525 0.146903771502071 750 3101745 SGTC_2678 equilin 100 µM 1.04755956801498 0.148425412519743 no 526 0.147420786944466 777 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2343 7990716 14.84 µM 1.04563816148245 0.148863192904825 no 527 0.14786406163884 774 6456862 SGTC_1130 3454-2858 15.9 µM 1.03999717938306 0.150153435891662 no 528 0.149170605552808 730 715628 YIL048W NEO1 SGTC_789 1309-1135 70.6 µM 1.03854440575062 0.150486927461006 no 529 0.149508336458674 751 3092424 SGTC_2405 ticlatone 3.52 µM 1.03721628479281 0.150792235778336 no 530 0.149817535147293 728 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1700 st030840 7.9285 µM 1.0357797356581 0.151122933497292 no 531 0.15015245675342 800 5499307 SGTC_3158 9100007 49.47 µM 1.03333356170801 0.151687159348191 no 532 0.150723913150368 688 19297233 SGTC_2611 pyromycin 23.93 µM 1.03328314073329 0.15169880397985 no 533 0.150735707323959 743 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_3167 9103034 49.47 µM 1.03039759320267 0.152366205822123 no 534 0.151411701299468 713 5127859 SGTC_451 chloral hydrate 100 µM 1.03009047374169 0.152437354441218 no 535 0.151483768345338 833 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2920 7982904 15.77 µM 1.02989246571563 0.152483237523179 no 536 0.151530243962762 696 6456808 SGTC_1721 st082152 9.2685 µM 1.02735158446537 0.153072832334602 no 537 0.152127470258212 723 5296051 SGTC_1358 1509-0022 2.48 µM 1.02635198660161 0.153305196084713 no 538 0.152362850495181 779 3258434 SGTC_1939 st074455 53.6 µM 1.0261066522859 0.153362261518769 no 539 0.152420657501978 792 1644229 SGTC_425 3825-7017 13.1 µM 1.02546075493375 0.153512566297067 no 540 0.152572916949592 802 3397440 SGTC_3336 9143619 71.43 µM 1.02521377869808 0.153570065150031 no 541 0.152631164109348 837 45595730 SGTC_427 1354-0053 47.3 µM 1.02374971018876 0.153911209632484 no 542 0.152976754605945 753 6813657 SGTC_1482 3346-2049 8.48 µM 1.02253246827189 0.154195222258062 no 543 0.153264476819961 758 3826804 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.02141693189149 0.154455808679889 no 544 0.153528473348128 746 115019 SGTC_409 arachidonic acid 100 µM 1.02046073340438 0.154679405769667 no 545 0.153755001433033 766 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_457 grayanotoxin iii 135 µM 1.0158046347661 0.155771241226651 no 546 0.154861214260021 823 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1152 3909-8331 15.9 µM 1.01517063995259 0.155920302471162 no 547 0.155012246703365 750 16001939 SGTC_473 2-arachidonoylglycerol 10 µM 1.0126965133954 0.156502904158776 no 548 0.155602571879773 768 5282280 An endocannabinoid. SGTC_3212 9128307 49.47 µM 1.01203130791501 0.156659789417415 no 549 0.155761542134806 673 27243542 SGTC_1324 1418-0026 34.4 µM 1.00789497794621 0.157637643787918 no 550 0.156752441419042 814 1372513 SGTC_2206 7254556 146.969 µM 1.00735180297082 0.157766350993793 no 551 0.15688287191995 770 4398905 SGTC_586 0957-0265 8.15 µM 1.00457038267889 0.15842649959778 no 552 0.157551882304906 718 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_372 0155-0182 15.9 µM 1.00263260335584 0.158887485940367 no 553 0.15801907949031 862 771486 SGTC_2412 st077135 33.4 µM 0.999992198731886 0.159517036339901 no 554 0.158657141617318 795 13258915 SGTC_2376 9072922 81.32 µM 0.995639222154106 0.160558474313145 no 555 0.159712735203034 816 17087968 SGTC_3145 9085516 49.47 µM 0.993730406839373 0.161016550942813 no 556 0.160177067568009 765 25236195 SGTC_485 niflumic acid 177 µM 0.9927927276024 0.161241886879743 no 557 0.160405487358295 775 4488 A COX2 inhibitor. SGTC_2313 7726885 200 µM 0.991732131956688 0.161497008965464 no 558 0.160664106131826 766 726423 SGTC_917 harmaline 728.087 nM 0.989020839722683 0.162150395328546 no 559 0.161326472817484 809 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1518 st038567 90.8 µM 0.988625033950369 0.162245923189538 no 560 0.161423316647712 806 77966 SGTC_2006 4011487 200 µM 0.986959131257068 0.162648390940132 no 561 0.161831337090655 854 45595294 SGTC_3178 9107506 49.47 µM 0.980970564047247 0.164100536027897 no 562 0.163303628832768 807 8897194 SGTC_1866 st057638 64 µM 0.979377376943881 0.164488273897646 no 563 0.16369677548883 801 688802 SGTC_1219 1469-0211 33.1 µM 0.977469972931946 0.164953263883094 no 564 0.164168268112226 811 6822282 SGTC_276 colchicine 750 µM 0.974157266982058 0.165762861447213 no 565 0.16498922941691 848 2833 A microtubule depolymerizer. SGTC_139 0099-0334 718.624 µM 0.973155477303707 0.166008195487456 no 566 0.165238017498685 961 97690 SGTC_1038 k292-0204 154 µM 0.969486293568195 0.166908765308043 no 567 0.166151307809591 766 4454212 SGTC_1882 5615643 20 µM 0.965951683832775 0.167779279339808 no 568 0.1670341792406 797 2253075 SGTC_2512 diallyl trisulfide 49.23 µM 0.963751114446363 0.168322715888087 no 569 0.167585360522064 815 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1669 st015249 58.4 µM 0.961858572025561 0.168790988818574 no 570 0.168060325596154 901 722793 SGTC_3229 9132204 49.47 µM 0.961562262702333 0.16886438053535 no 571 0.168134767717047 841 17682924 SGTC_2349 9023730 187.07 µM 0.960793766971957 0.169054821813549 no 572 0.168327936607052 839 4126287 SGTC_246 cycloheximide 667 µM 0.960463685842453 0.169136661698768 no 573 0.168410949519111 737 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_87 0100-0052 35.5 µM 0.959557318777841 0.169361515980344 no 574 0.168639029361692 1028 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2602 kawain 100 µM 0.957664897851439 0.169831611668254 no 575 0.169115881293894 907 5369129 SGTC_334 1502-1024 68.5 µM 0.957366711129286 0.169905760371169 no 576 0.169191097226875 872 3296216 SGTC_2396 5342950 42.78 µM 0.954052599872833 0.170731261882184 no 577 0.170028508841556 846 1886677 SGTC_1683 st010134 710 nM 0.950707745978472 0.171567019363035 no 578 0.170876377482593 837 3818134 SGTC_2855 9016525 58.44 µM 0.950459307349142 0.171629199270781 no 579 0.170939460575761 857 43811474 SGTC_2795 7780010 54.55 µM 0.949156519688759 0.171955500236574 no 580 0.171270505975508 805 953673 SGTC_829 1635-0120 117 µM 0.947881904174414 0.172275128160119 no 581 0.171594789097341 897 285054 SGTC_2572 astragaloside iv 100 µM 0.946565600363917 0.172605607618342 no 582 0.17193008987918 833 45006101 An anti-inflammatory agent. SGTC_1189 1431-2119 7.28 µM 0.945373039055022 0.172905368278687 no 583 0.172234230790217 888 3107275 SGTC_2812 7970281 58.44 µM 0.94363158060855 0.173343694512464 no 584 0.172678974140688 862 2233435 SGTC_656 4090-1979 187 µM 0.941883474010571 0.173784404921722 no 585 0.173126150972002 917 22330961 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.940149793421028 0.174222181674581 no 586 0.173570365330772 835 5355888 SGTC_475 α-linolenic acid 10 µM 0.938414659582371 0.174661026451771 no 587 0.174015677585164 919 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1675 st018485 24.5 µM 0.936336195555418 0.175187628285598 no 588 0.174550058842993 860 3323024 SGTC_175 3793-3120 23.7 µM 0.933767431168595 0.175839842874006 no 589 0.175211936522261 823 5322297 SGTC_1502 4534-4282 27.7 µM 0.930495471095728 0.176672824284664 no 590 0.17605730396996 849 3278949 SGTC_848 0368-0089 85.6 µM 0.929331300952359 0.176969801593077 no 591 0.176358709247249 895 762535 SGTC_1646 st011709 75.6 µM 0.929153695391436 0.177015136108307 no 592 0.176404720261036 843 5757843 SGTC_2936 9038235 15.59 µM 0.927160354356458 0.177524447454094 no 593 0.176921641817362 860 4749415 SGTC_2389 9091542 195.52 µM 0.924350866222833 0.178243858346447 no 594 0.177651833648253 881 3626624 YOL127W RPL25 SGTC_1364 1653-0028 37.6 µM 0.922133309129851 0.178812992128607 no 595 0.178229522220268 857 5718652 SGTC_415 dibenzyl ketone 100 µM 0.921441456880282 0.17899078916852 no 596 0.178409996431716 895 7593 SGTC_2370 9071495 200 µM 0.919436543246492 0.179506653926904 no 597 0.178933641303094 831 21791103 SGTC_89 0302-0250 142.109 µM 0.91930519425523 0.179540482640084 no 598 0.178967980858407 950 4203518 YLR208W SEC13 SGTC_2961 9083290 32.55 µM 0.919051108958577 0.179605933255267 no 599 0.179034420059051 850 17741490 SGTC_1788 fluconazole 20 µM 0.91866273774874 0.179706003964151 no 600 0.179136002840988 829 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2252 omeprazole 400 µM 0.918030677807931 0.179868940266579 no 601 0.179301402605534 812 4594 A proton pump inhibitor. SGTC_1361 1608-0041 5.61 µM 0.916341563602846 0.180304825661826 no 602 0.179743887262099 882 X1361 SGTC_3290 9121031 71.43 µM 0.912705471193938 0.18124538666232 no 603 0.180698732826442 836 17014854 SGTC_2836 9010338 19.48 µM 0.911896821902903 0.181454979797635 no 604 0.180911517362317 847 2994051 SGTC_1225 1216-0074 20.6 µM 0.910471588352442 0.181824754086289 no 605 0.181286929365839 911 4241466 SGTC_744 1594-0068 283 µM 0.909583025401588 0.18205552851179 no 606 0.181521226967038 935 668392 SGTC_1913 st060213 96.1 µM 0.909403804151838 0.182102097403976 no 607 0.181568507252252 946 688959 SGTC_2031 5180455 200 µM 0.908950576405082 0.18221989743373 no 608 0.181688107466754 868 29949 SGTC_899 1083-0020 478 µM 0.906926965053414 0.182746442279832 no 609 0.182222710257088 913 767123 SGTC_919 tnp00227 403.569 nM 0.906146759235619 0.182949705743145 no 610 0.182429089337713 924 1269246 A methoxyflavone. YNL221C POP1 SGTC_453 enantio-paf c16 10 µM 0.905610522485154 0.183089490830994 no 611 0.18257101865539 968 13871343 A lipid and platelet activating factor SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.905467990409423 0.18312665700374 no 612 0.182608755157864 938 165506 SGTC_1806 st050005 60.3 µM 0.905171602897594 0.183203957056617 no 613 0.182687241706781 881 5194765 SGTC_1002 4049-0206 172 µM 0.897662657588629 0.185169129950869 no 614 0.184682711729117 932 4662749 SGTC_2881 9058953 51.95 µM 0.89732407737574 0.185258047479185 no 615 0.184773006118328 969 17122249 SGTC_2943 9068529 45.32 µM 0.896431324554027 0.185492628249002 no 616 0.185011221779373 1006 3270634 SGTC_1367 1812-0510 76.9 µM 0.896414910911752 0.185496942841936 no 617 0.185015603261704 899 1142582 YDR527W RBA50 SGTC_1711 st032263 62.8 µM 0.895578191714019 0.185716970611824 no 618 0.185239043743675 894 3958979 SGTC_2900 5328528 85.29 µM 0.894763729134163 0.18593130110737 no 619 0.185456701612654 988 795359 SGTC_1770 st043884 66.3 µM 0.894581018324325 0.185979403559219 no 620 0.185505551240841 957 670149 SGTC_1321 1326-2144 215 µM 0.889668489674576 0.187275621078846 no 621 0.186821959197586 931 3513030 SGTC_786 4544-0069 423 µM 0.888071098675953 0.187698308512853 no 622 0.187251253902288 938 748821 YLR208W SEC13 SGTC_695 3505-6186 243 µM 0.887901790764585 0.187743143786377 no 623 0.187296790690048 926 1819379 SGTC_3020 9089140 49.47 µM 0.887118048795261 0.187950776586623 no 624 0.187507673879971 946 17217859 SGTC_692 k241-0027 77.8 µM 0.884132729338774 0.188742959908866 no 625 0.188312283537653 924 3600480 SGTC_924 2046-0044 21.3 µM 0.883839658792772 0.188820839782447 no 626 0.188391387187962 966 3623589 SGTC_926 2268-1401 59.4 µM 0.882926006322136 0.189063758701867 no 627 0.188638125698686 952 2931578 SGTC_1375 2910-0797 186 µM 0.882189501614627 0.189259718209962 no 628 0.188837169119281 918 742508 SGTC_1614 st002383 48.6 µM 0.88213934592245 0.18927306752452 no 629 0.18885072860618 929 1947235 SGTC_3188 9110789 49.47 µM 0.879036448780513 0.190100053842405 no 630 0.189690756728462 936 849217 SGTC_1757 st041620 31.8375 µM 0.877717863180097 0.190452155479652 no 631 0.190048424006192 942 5289815 SGTC_49 0717-0965 32.132 µM 0.877268901692753 0.190572132904406 no 632 0.190170299655447 1012 5889349 YGL099W LSG1 SGTC_2796 7949634 45.45 µM 0.877169011883012 0.190598833088962 no 633 0.190197422398242 869 2971588 SGTC_2643 anethole 100 µM 0.875594083493606 0.191020109221734 no 634 0.190625371478627 984 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_527 4476-4215 268 µM 0.875538038862775 0.191035111063014 no 635 0.190640611148002 911 4418754 SGTC_3049 9092223 49.47 µM 0.875138048321354 0.191142200186916 no 636 0.190749398384978 899 8623917 SGTC_2059 5238311 157 µM 0.874891641288122 0.191208188848108 no 637 0.190816433779215 892 703021 SGTC_1289 0976-0073 69.1 µM 0.872874537059925 0.191748901348373 no 638 0.191365733268966 964 3391136 SGTC_2822 7994718 71.43 µM 0.872741576024837 0.191784576243231 no 639 0.19140197534013 845 1018011 SGTC_1335 1486-0900 202 µM 0.872517002656225 0.191844840953722 no 640 0.191463198343487 967 X1335 SGTC_257 daunorubicin 18.5 µM 0.872225069236187 0.19192319919691 no 641 0.191542802922499 947 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_265 mycophenolic acid 32.932 µM 0.872121108659523 0.191951108125253 no 642 0.191571155849637 987 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2291 7917025 104.35 µM 0.870388476299067 0.19241661075226 no 643 0.192044071056917 904 2964612 SGTC_2447 5741742 33.78 µM 0.86924269922622 0.19272482304634 no 644 0.192357198485313 961 1776504 SGTC_260 nsc-65238 3.989 µM 0.8677603136405 0.193124029840372 no 645 0.192762780034987 926 3246252 SGTC_2924 9010168 62.78 µM 0.866433243564272 0.193481838048449 no 646 0.193126310054358 947 2993929 SGTC_1227 3909-8010 46.6 µM 0.864389563081113 0.194033650970221 no 647 0.19368696216768 917 15982272 SGTC_628 1636-0253 16 µM 0.863168770592408 0.194363733397454 no 648 0.19402234066415 954 4456143 SGTC_428 3448-4153 16.5 µM 0.860675640034404 0.195038896514503 no 649 0.194708356634738 872 3834874 SGTC_339 3091-4833 71.4 µM 0.860577955769651 0.195065379322712 no 650 0.19473526568614 943 3240077 SGTC_3247 9135149 49.47 µM 0.860091935452466 0.195197174926901 no 651 0.194869183165269 905 8934436 YOR116C RPO31 SGTC_2304 7443016 91.4 µM 0.858995879017054 0.19549459444074 no 652 0.195171394799587 885 939854 SGTC_2858 9025781 8.96 µM 0.857011807441332 0.196033680127198 no 653 0.19571917958896 1037 4894980 YPL153C RAD53 SGTC_1531 st059297 52.4 µM 0.856377025459634 0.196206344911634 no 654 0.195894634203837 971 7566702 SGTC_964 1287-0107 19.4 µM 0.856188275563055 0.196257703879576 no 655 0.195946823338125 978 51516812 YPR165W RHO1 SGTC_3050 9093513 49.47 µM 0.855288113331049 0.19650275070734 no 656 0.196195833208042 999 25236664 SGTC_2882 9058044 58.44 µM 0.854138918200087 0.196815859857398 no 657 0.196514011198671 970 18076804 SGTC_3113 9123498 49.47 µM 0.852330000906683 0.197309328202322 no 658 0.197015479638095 1038 8897275 SGTC_1689 st020265 53.493 µM 0.85185775859237 0.19743827787064 no 659 0.197146522139125 972 5758320 YPR016C TIF6 SGTC_3298 9116858 71.43 µM 0.850465387767081 0.197818772761232 no 660 0.197533197946766 988 2506942 SGTC_1942 st076330 65.2 µM 0.849848888819792 0.19798738560005 no 661 0.197704552444631 1013 24208414 SGTC_1315 1237-0019 3.69 µM 0.849189670722196 0.198167778150371 no 662 0.197887879984896 1002 825140 SGTC_979 1426-2828 121 µM 0.848754014314202 0.198287048324548 no 663 0.198009091702335 1009 747872 SGTC_1748 st037455 53.6035 µM 0.84842181114801 0.198378025089612 no 664 0.198101549978179 946 580690 SGTC_699 0375-0592 111 µM 0.848117079238248 0.198461500754832 no 665 0.198186385415257 1020 762578 SGTC_2638 epoxomicin 18 µM 0.846000092875761 0.199041994754261 no 666 0.198776346230084 998 9915668 A protesome inhibitor. SGTC_3159 9100096 49.47 µM 0.844752832169386 0.199384481695823 no 667 0.199124427420131 986 25236875 SGTC_1861 st057647 17.4 µM 0.843300215859469 0.199783804425437 no 668 0.199530281065847 990 688668 SGTC_1378 2093-0007 380 nM 0.842650300278105 0.1999626212101 no 669 0.199712025283029 952 3618014 SGTC_2991 9074669 71.4286 µM 0.839624401015225 0.200796428818371 no 670 0.200559506721204 1001 17333109 SGTC_266 formosanin C 406 nM 0.834722588136698 0.202151577241712 no 671 0.201936960282543 990 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1829 berberine 14.4 µM 0.831780081472973 0.202967680441265 no 672 0.202766544445547 989 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.831183139681386 0.203133481793489 no 673 0.202935089017191 1021 4213774 SGTC_819 1013-0258 27.7 µM 0.829757679075579 0.203529732247093 no 674 0.203337901504938 990 5753198 SGTC_2917 7979103 53.79 µM 0.829401540756292 0.203628803740006 no 675 0.203438614968778 1019 2980565 SGTC_3231 9132313 49.47 µM 0.829135918581446 0.2037027139333 no 676 0.203513750461751 987 4905967 SGTC_1252 0493-0875 34.8 µM 0.828732610632297 0.203814966194581 no 677 0.203627864224437 953 3960963 SGTC_1940 st075990 51.1 µM 0.828463301329279 0.20388994328531 no 678 0.203704085049788 1065 1084979 SGTC_113 0099-0221 2.5 µM 0.828032620517248 0.204009881188576 no 679 0.20382601312975 960 89219 SGTC_837 0091-0265 12.5 µM 0.826918401392099 0.204320368860812 no 680 0.204141656402503 993 759367 SGTC_1435 4092-0789 56.7 µM 0.826556440193439 0.204421293274752 no 681 0.204244257753848 1022 2248285 SGTC_209 4077-0173 175.592 µM 0.825022249052932 0.204849395909893 no 682 0.204679479643242 906 15993494 SGTC_2756 carbadox 75.1 µM 0.823053981828941 0.205399403711519 no 683 0.205238648143923 965 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1767 st044992 70.3 µM 0.820316119530452 0.206165922022032 no 684 0.206017959704989 1032 9600693 SGTC_3057 9095946 49.47 µM 0.818501069863508 0.206675014316984 no 685 0.206535565692107 1050 24540043 SGTC_2272 7805186 180 µM 0.81771211359054 0.206896535800557 no 686 0.206760795930102 1011 2956062 YPR165W RHO1 SGTC_3134 9127454 49.47 µM 0.817125152801942 0.207061432544236 no 687 0.206928455049857 1046 24262820 SGTC_2734 clemastine 41.6 µM 0.816694116248102 0.207182574501271 no 688 0.20705162728812 947 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2028 5153890 36.43 µM 0.814110911319625 0.207909457005465 no 689 0.207790707806753 992 2830968 YPR165W RHO1 SGTC_2867 9039098 71.43 µM 0.813902738250627 0.2079680998716 no 690 0.20785033595252 981 6463460 SGTC_2189 6047310 154.431 µM 0.81314553332377 0.208181488710712 no 691 0.208067311491795 998 711535 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.812753854729768 0.208291918813304 no 692 0.208179598644354 978 4620898 SGTC_1604 st002052 72.4 µM 0.81091289041957 0.208811424162585 no 693 0.208707848562312 1025 6254834 YHR062C RPP1 SGTC_1816 st051957 91.6 µM 0.810663105833234 0.208881970142996 no 694 0.208779583059823 1021 674121 SGTC_319 1348-1596 45.5 µM 0.810596509754047 0.208900781062854 no 695 0.208798710937379 1041 5380505 SGTC_1286 0929-0070 131 µM 0.810182965047407 0.209017614426859 no 696 0.208917513303949 1039 1420408 SGTC_986 1493-0483 84 µM 0.806935448549663 0.209936429546403 no 697 0.209851837186897 1007 40079 SGTC_19 0279-0214 38.434 µM 0.803258090511722 0.21097971950078 no 698 0.210912787930745 1137 3566274 YBR002C RER2 SGTC_3332 9141069 11.198 µM 0.802172567030006 0.21128826952538 no 699 0.211226571387885 999 17332883 SGTC_748 act1.228 77.9 µM 0.801635532070221 0.211441014443055 no 700 0.211381908800187 1023 4421505 YNR035C ARC35 SGTC_483 fpl-64176 144 µM 0.801507700769338 0.211477382089029 no 701 0.211418893872167 1022 3423 SGTC_1850 st056238 17 µM 0.801102946639439 0.211592557659205 no 702 0.211536025244992 1109 5393177 SGTC_1731 st035964 63 µM 0.796294368630225 0.212963678691675 no 703 0.212930478983564 984 6739575 SGTC_2256 7954252 200 µM 0.794265653606831 0.213543699340309 no 704 0.213520397331465 927 2972920 SGTC_760 0568-0725 82.9 µM 0.793414865530791 0.213787217985809 no 705 0.21376807627997 1085 3916171 SGTC_3331 9141060 1.957 µM 0.793371580032539 0.21379961179249 no 706 0.213780681899757 1011 4906567 YPR165W RHO1 SGTC_685 1278-0033 54.9 µM 0.792815890639626 0.213958757829561 no 707 0.213942548431547 1054 3590572 SGTC_2874 9043904 71.43 µM 0.792079824283039 0.214169668862246 no 708 0.214157066705517 952 4463428 SGTC_1151 3909-8316 15.3 µM 0.788037303749019 0.215330159503514 no 709 0.215337443064135 1044 800431 SGTC_1108 betulinic acid 729.144 nM 0.787982431992937 0.215345936654541 no 710 0.215353491003386 1072 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2685 mycophenolic acid 18.85 µM 0.785792712891839 0.215976088850679 no 711 0.215994468221502 1046 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1634 st006576 41 µM 0.785787711378404 0.215977529396177 no 712 0.215995933534531 1062 3915356 SGTC_895 0964-0006 13.7 µM 0.781791097028973 0.217130420227033 no 713 0.217168677045589 1065 6738897 SGTC_489 paxilline 115 µM 0.78098236875192 0.217364143325392 no 714 0.217406432306374 1056 105008 A toxic potassium channel blocker. SGTC_2752 diclazuril 33.15 µM 0.780552426862228 0.2174884559846 no 715 0.217532890612545 1162 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_3254 9136651 49.47 µM 0.777997168977595 0.21822812512622 no 716 0.218285341091289 1097 16454030 SGTC_3246 9135460 32.98 µM 0.777185639145542 0.218463341169038 no 717 0.218524626832567 1024 41446951 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.77541089398613 0.218978246668303 no 718 0.219048449934058 1092 6312947 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.774811457737043 0.219152318236276 no 719 0.219225538932457 1105 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2485 5633444 17.78 µM 0.774614967919315 0.219209394640671 no 720 0.219283605019687 1045 5724239 SGTC_2322 7413319 38.22 µM 0.773683654099028 0.219480039087793 no 721 0.219558944324732 1093 1840400 SGTC_1017 4239-0030 168 µM 0.771858823520345 0.220010900148656 no 722 0.220099023713639 1080 1149593 SGTC_2803 7707263 71.43 µM 0.77152637858363 0.220107690898149 no 723 0.220197496573144 1038 2199229 SGTC_1034 k072-0165 12.7 µM 0.770677533348253 0.220354941442871 no 724 0.220449045930094 1095 5835461 SGTC_1036 k216-0215 33.5 µM 0.770023054847814 0.220545685751062 no 725 0.220643108456405 1063 622330 SGTC_2792 7535235 81.82 µM 0.769918798872485 0.220576079338568 no 726 0.220674030924079 1031 1281891 SGTC_516 3992-2719 87.3 µM 0.768576414199614 0.220967637040525 no 727 0.221072405781168 1085 5350887 YDR037W KRS1 SGTC_2681 menadione 3.18 µM 0.768330563711001 0.221039391795413 no 728 0.221145410542643 1106 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_416 estradiol valerate 100 µM 0.767511280989275 0.22127860665999 no 729 0.221388794291644 1085 13791 A steroid. SGTC_730 1436-0052 41.2 µM 0.767187428168754 0.221373206299688 no 730 0.221485043245487 1117 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2335 9018011 154.17 µM 0.765742225370835 0.221795641753819 no 731 0.221914848496226 1111 6458208 SGTC_1341 1486-1360 280 µM 0.765456446672294 0.221879229894165 no 732 0.221999895834615 1108 3976547 SGTC_2360 9040895 200 µM 0.765327690336953 0.221916896041219 no 733 0.222038219618864 1037 4914414 SGTC_2922 7999257 32.47 µM 0.763533317334064 0.222442198590902 no 734 0.222572700174568 1043 2988377 SGTC_804 1595-0054 20.9 µM 0.762455487795269 0.222758073724055 no 735 0.222894099973945 1047 761523 Stimulates phospholipase C. SGTC_1442 4112-3290 3 µM 0.762291014873271 0.222806297606128 no 736 0.222943167671526 1114 704353 SGTC_666 0272-0154 136 µM 0.760369352739436 0.223370174468872 no 737 0.223516918590434 1099 6870312 SGTC_807 1315-0151 48 µM 0.760325680724465 0.223382998658483 no 738 0.223529967502986 1145 4011080 SGTC_3074 9116018 49.47 µM 0.758063408726677 0.224047882467053 no 739 0.224206511914312 1124 17027303 SGTC_1904 st060225 78 µM 0.758030586964818 0.224057537079039 no 740 0.224216335985405 1103 66595 SGTC_974 1326-0144 138 µM 0.757855914100113 0.224108921560448 no 741 0.224268622440917 1124 5411856 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.756692605078205 0.224451309280474 no 742 0.224617023093779 1074 1609 A potent and irreversible inhibitor of serine proteases. SGTC_905 2-aminofluorene 215 µM 0.756634147333652 0.224468522524818 no 743 0.224634538763838 1169 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1293 1000-1278 195 µM 0.756119094656416 0.224620215342999 no 744 0.224788897268148 1114 678847 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.755791302596801 0.224716786617776 no 745 0.224887166087352 1032 6857784 SGTC_2622 2-methoxyxanthone 59.94 µM 0.755652837682204 0.224757587031853 no 746 0.22492868381516 1117 71034 A hepatoprotective. SGTC_2657 nystatin 74.44 µM 0.752599848671785 0.225658255074097 no 747 0.225845204303204 1147 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3046 9092212 49.47 µM 0.751961866027283 0.225846725161702 no 748 0.226036995889662 1116 25236637 SGTC_2892 9047358 58.44 µM 0.750795310468851 0.226191574083378 no 749 0.226387926063701 1082 6466771 SGTC_3327 9140648 26.9345 µM 0.749401626940604 0.226603954756043 no 750 0.22680758533212 1103 8029710 SGTC_1068 loratadine 26.9 µM 0.749301806912445 0.226633507043167 no 751 0.226837659491628 1090 3957 A H1 histamine antagonist. SGTC_2758 dehydroepiandrosterone 69.35 µM 0.749186275052763 0.226667713623048 no 752 0.226872470180232 1098 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_651 3253-0966 34.4 µM 0.748892999705717 0.226754559436493 no 753 0.226960849958847 1130 781462 SGTC_193 1273-0060 1.558 µM 0.748867708971604 0.226762049504303 no 754 0.226968472338888 997 2847393 YHR072W ERG7 SGTC_2782 7736369 71.43 µM 0.748472414812599 0.226879137400709 no 755 0.227087628895141 1152 2950836 YOL077C BRX1 SGTC_2092 5303694 80.6725 µM 0.748151439466885 0.226974236815191 no 756 0.227184408899877 1097 1963699 SGTC_1267 0828-0272 9.49 µM 0.747862667850189 0.227059814031073 no 757 0.227271498746987 1133 745334 SGTC_370 0180-0345 38.7 µM 0.747802672755819 0.227077595806895 no 758 0.227289594864509 1041 3989527 SGTC_13 0199-0087 65 µM 0.746533146359247 0.227454051163797 no 759 0.22767270813406 1141 4589825 SGTC_2969 9091408 28.7 µM 0.746144515896865 0.227569362817173 no 760 0.227790060321512 1039 4286311 SGTC_1119 parthenolide 318.541 nM 0.743782651179956 0.228270865948333 no 761 0.228503988747262 1178 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1340 1486-1359 257 µM 0.743130588682328 0.228464750497487 no 762 0.228701310961646 1111 4309068 SGTC_1910 st062352 60.4 µM 0.742862365127072 0.228544531055586 no 763 0.228782506506335 1121 2245730 SGTC_2116 5511452 16.8835 µM 0.73996458504136 0.229407445443308 no 764 0.229660741824517 1107 870744 SGTC_2347 9049783 174.81 µM 0.739439557680611 0.229563985697573 no 765 0.229820064613125 1129 6467988 YPL169C MEX67 SGTC_1667 st014849 34.6 µM 0.737728089219044 0.230074686214315 no 766 0.230339849688543 1165 5348460 SGTC_2381 9035592 200 µM 0.736388704669836 0.230474800276057 no 767 0.23074708834301 1067 4749657 SGTC_543 3844-1095 191 µM 0.735620827134721 0.230704363465365 no 768 0.230980742067332 1149 4230703 SGTC_2963 9082507 9 µM 0.735134437249947 0.230849839704178 no 769 0.231128811583249 1118 16459611 SGTC_3256 9138902 49.47 µM 0.734261922847685 0.231110931747628 no 770 0.23139455995897 1165 17228773 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.732296202200426 0.231699759293027 no 771 0.231993898430356 980 4000243 SGTC_1453 4237-0541 195 µM 0.730526509151893 0.232230581467499 no 772 0.232534207600014 1132 739892 SGTC_500 h-89 112 µM 0.729138238303911 0.232647468675757 no 773 0.232958553124607 1163 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1381 2324-0066 62.1 µM 0.728880275366598 0.232724978795 no 774 0.233037450671655 1107 10885928 SGTC_337 1315-0038 354 µM 0.727352165662889 0.233184424083409 no 775 0.233505124716817 1115 1626437 SGTC_707 0865-0008 204 µM 0.727088088921449 0.233263873049708 no 776 0.233585997444586 1161 723043 SGTC_2728 chlorpromazine 9.18 µM 0.726749006841431 0.233365909817899 no 777 0.233689863109318 1140 2726 A thorazine and dopamine antagonist. SGTC_1374 2889-5571 141 µM 0.72617966495376 0.233537292181939 no 778 0.233864318201216 1140 2853281 SGTC_853 0419-0306 21 µM 0.726077345310314 0.233568099671519 no 779 0.233895678158589 1103 762713 SGTC_1447 4239-0816 81.9 µM 0.72452391468778 0.234036099874518 no 780 0.234372075371059 1129 1341554 SGTC_3223 9129970 49.47 µM 0.723082923760347 0.234470689459179 no 781 0.234814469876712 1180 17248386 SGTC_1459 k035-0031 35.7 µM 0.721956458666747 0.234810731649198 no 782 0.235160623911149 1058 3877128 YMR208W ERG12 SGTC_550 4123-0385 25.7 µM 0.720680726835849 0.235196161429271 no 783 0.235552986528351 1161 5731123 SGTC_2865 9030313 51.95 µM 0.720193199865231 0.235343547462905 no 784 0.235703025094124 1111 42562754 SGTC_2864 9034755 47.6 µM 0.719836788088416 0.235451327841714 no 785 0.235812745724058 1171 4930451 SGTC_825 1988-2224 89.6 µM 0.719337824380208 0.235602262256853 no 786 0.235966397966079 1142 1180859 SGTC_2336 9001819 198.65 µM 0.718941350053532 0.235722232111189 no 787 0.236088528677928 1196 2989602 SGTC_1930 st074634 34.3 µM 0.718795819724937 0.235766276836593 no 788 0.236133366855481 1148 684253 YOR116C RPO31 SGTC_2155 5570423 76 µM 0.71826260935287 0.235927691616254 no 789 0.236297690082662 1114 797402 SGTC_223 busulfan 5 mM 0.717902242811045 0.236036817162498 no 790 0.236408782446733 1120 2478 A DNA alkylator. SGTC_3077 9117319 49.47 µM 0.716189431462343 0.236555867652431 no 791 0.236937193982651 1191 17154678 SGTC_2358 9037157 4 µM 0.713171243736632 0.237472026016923 no 792 0.237869899133326 1164 2388925 SGTC_941 3237-0776 460 µM 0.712365426913603 0.237716957388984 no 793 0.238119259362256 1159 760008 SGTC_3198 9112019 49.47 µM 0.711856417247661 0.237871744382189 no 794 0.238276846330505 1196 45595555 SGTC_946 3434-1334 87.4 µM 0.711188735112127 0.23807486655471 no 795 0.238483644126455 1131 4047976 SGTC_180 1486-1293 102.781 µM 0.710837519123004 0.238181751579297 no 796 0.238592463895493 1188 4140536 SGTC_1426 4048-4480 71.7 µM 0.710312014382075 0.238341726722078 no 797 0.238755335538365 1161 14224343 SGTC_504 lovastatin 124 µM 0.708650145048133 0.238848023207561 no 798 0.239270804999763 1150 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1150 3909-7983 10.9 µM 0.708638193156138 0.238851666538177 no 799 0.239274514372466 1179 23965914 SGTC_3041 9091929 49.47 µM 0.708035305452468 0.239035486013673 no 800 0.239461666524642 1250 25236887 SGTC_1819 st053448 58.6 µM 0.708021446452879 0.239039712509131 no 801 0.239465969661195 1140 2857616 SGTC_3296 9122258 64.045 µM 0.707986104814863 0.239050490620091 no 802 0.23947694321973 1161 4730474 SGTC_2129 girgensonine 121.053 µM 0.70738754456075 0.239233073405047 no 803 0.239662837538497 1209 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_352 k048-0007 5.11 µM 0.705229307848027 0.239892046838211 no 804 0.240333772633586 1168 6811911 SGTC_2856 9022925 19.48 µM 0.702059639397768 0.240861632332001 no 805 0.241320985567214 1172 4944862 SGTC_2025 5147754 141 µM 0.701829507314168 0.240932111487095 no 806 0.241392747330846 1197 315777 YLR208W SEC13 SGTC_168 3970-0862 530.542 µM 0.700867153898484 0.241226958754081 no 807 0.241692962205145 1218 3135186 SGTC_127 0180-0333 59.125 µM 0.700279747290125 0.241407025599956 no 808 0.241876308584752 1174 771601 SGTC_911 3456-4043 236 µM 0.700075718738343 0.241469586713351 no 809 0.241940009375796 1225 914281 SGTC_752 1896-0090 130 µM 0.69787197112338 0.242145880997338 no 810 0.242628632269303 1192 772567 SGTC_1088 bifonazole 369 nM 0.69690186581604 0.242443915738345 no 811 0.242932105018958 1139 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1922 5578187 25 µM 0.694568586239857 0.243161556488222 no 812 0.243662852310601 1199 1350412 SGTC_162 k030-0015 37.8 µM 0.693557777851979 0.243472804388284 no 813 0.243979790024399 1255 1809920 YMR134W ERG29 SGTC_512 prima-1 270 µM 0.69314993387463 0.243598448529637 no 814 0.244107731939325 1194 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2342 7990637 118.86 µM 0.692954567564874 0.243658647261409 no 815 0.244169031768902 1236 2033102 YER133W GLC7 SGTC_1255 0566-0045 221 µM 0.691484161832812 0.24411198485317 no 816 0.244630665250031 1204 2788469 SGTC_1900 st060200 72.8 µM 0.691380624628574 0.244143923316579 no 817 0.244663188431099 1216 688945 SGTC_1385 3091-4834 14.1 µM 0.690967932706859 0.24427125014472 no 818 0.244792846647499 1159 4072814 SGTC_3137 9097352 49.47 µM 0.689862888271219 0.244612362974286 no 819 0.24514020798168 1302 44120435 SGTC_2979 9012552 45.46 µM 0.689428251527687 0.244746599939543 no 820 0.245276904950088 1243 17100905 SGTC_669 0108-0021 26.2 µM 0.688933937388328 0.244899316374934 no 821 0.245432420759654 1284 17201 SGTC_35 0133-0054 64.071 µM 0.688159371242994 0.245138718675141 no 822 0.24567621297016 1160 99677 SGTC_1058 3448-5425 97.3 µM 0.687425499940766 0.245365659106758 no 823 0.245907316528235 1154 7279705 SGTC_2418 pentamidine 31.67 µM 0.687403355087465 0.245372508877567 no 824 0.245914291981306 1198 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2003 4023581 200 µM 0.687186247120456 0.245439669419087 no 825 0.245982684891531 1220 16641307 SGTC_1030 k029-0042 36.7 µM 0.685708881320075 0.245896942410625 no 826 0.246448352552497 1209 6080581 SGTC_362 0310-0100 9.03 µM 0.684311808161645 0.246329783554325 no 827 0.246889146075305 1235 790235 SGTC_2181 6316240 54.2555 µM 0.684295568681851 0.2463348172694 no 828 0.246894272307885 1202 12779990 SGTC_217 ketoconazole 989 nM 0.680971723542509 0.247366261682304 no 829 0.247944691337973 1167 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.680708060244384 0.247448179496181 no 830 0.248028117578067 1297 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2348 9022543 33.42 µM 0.680131490386506 0.24762736506331 no 831 0.248210603390928 1221 3162678 YDL140C RPO21 SGTC_1198 1612-1005 86.7 µM 0.679737072099581 0.247749981732258 no 832 0.248335479002946 1278 6998509 SGTC_1567 st069303 68.4 µM 0.677693070623252 0.248385939450968 no 833 0.24898316044419 1259 5581319 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.676595012173137 0.248727941362953 no 834 0.249331472317844 1278 94937 An inhibitor of serotonin biosynthesis. SGTC_2089 5281248 129.67 µM 0.676114496633472 0.248877681846359 no 835 0.249483976672869 1232 2737878 SGTC_2914 7968218 45.32 µM 0.675521945846012 0.249062401324166 no 836 0.249672106616075 1173 2977111 SGTC_1558 st069300 45.6 µM 0.675114449241283 0.249189475046283 no 837 0.249801527107888 1179 24208000 SGTC_346 4513-0042 7.16 µM 0.674734164757788 0.249308094038317 no 838 0.249922337180773 1229 2827372 SGTC_988 1497-1057 103 µM 0.672398155557929 0.250037404158084 no 839 0.2506651283484 1240 3533044 SGTC_749 1000-0129 128 µM 0.672391558629836 0.250039465343422 no 840 0.250667227657195 1291 708470 SGTC_3316 9136639 10.545 µM 0.671586260454786 0.250291145430863 no 841 0.250923563768297 1244 4903665 SGTC_3209 9113616 49.47 µM 0.669076168643515 0.251076486210026 no 842 0.251723445565526 1259 16649353 SGTC_3192 9110362 49.47 µM 0.668926865890601 0.251123240101655 no 843 0.251771065720451 1300 16649480 SGTC_958 1222-0007 33 µM 0.666894661162995 0.251760079076641 no 844 0.252419710695279 1303 7312461 SGTC_1461 k072-0203 53.8 µM 0.666876775757778 0.251765687670617 no 845 0.252425423317865 1192 5418714 SGTC_2074 5212007 75.395 µM 0.665201321850989 0.252291377233735 no 846 0.25296086757588 1184 758611 SGTC_2974 9094440 9.66 µM 0.663794222249625 0.252733314780315 no 847 0.253411012066138 1296 25236134 SGTC_1494 4358-1428 177 µM 0.663697486435937 0.252763712238054 no 848 0.253441974228178 1285 1564571 SGTC_1977 st070720 65.3 µM 0.663075173956033 0.252959308553492 no 849 0.253641204856918 1240 682188 SGTC_2505 galangin 7.89 µM 0.66267480484643 0.253085188911557 no 850 0.253769424753615 1181 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_125 0133-0007 11.75 µM 0.66236859585607 0.253181486549166 no 851 0.253867512436969 1317 26541 SGTC_2718 lomofungin 53.02 µM 0.661818756579278 0.25335445021665 no 852 0.254043691953092 1280 5351222 A RNA synthesis inhibitor. SGTC_943 3253-1379 105 µM 0.660047355415859 0.253912104329104 no 853 0.254611720269929 1252 668464 SGTC_1490 4089-0339 670 nM 0.660043793304957 0.253913226364496 no 854 0.254612863188002 1209 742542 SGTC_2980 9014342 25.29 µM 0.660030455900659 0.253917427559348 no 855 0.254617142573419 1257 2996599 SGTC_2895 9054447 58.44 µM 0.658722105375821 0.25432972664075 no 856 0.255037117650071 1273 2697450 SGTC_1564 D-Arginine 115 µM 0.65750950559872 0.254712165010419 no 857 0.255426680469746 1213 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.657374556330124 0.254754744886698 no 858 0.255470053827413 1285 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_253 dyclonine 31.25 µM 0.656093035551248 0.255159282468203 no 859 0.255882132609069 1322 3180 An oral anasthetic. SGTC_1955 wogonin 32.4 µM 0.654941799101719 0.25552297944495 no 860 0.256252613441982 1322 5281703 A flavanone. SGTC_1734 st037168 69.4 µM 0.653884250616377 0.255857317156792 no 861 0.256593190699947 1252 708907 SGTC_2531 methyl deoxycholate 70.07 µM 0.653572823502991 0.255955816499873 no 862 0.256693528880826 1246 16667744 Haematoxylin. SGTC_1230 0170-0365 3.77 µM 0.65043286367583 0.256950039153346 no 863 0.257706327473171 1345 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1228 0124-0032 52.5 µM 0.647513393713242 0.257876246234535 no 864 0.258649864454059 1318 X1228 SGTC_2592 piperlongumine 83.33 µM 0.644787299539826 0.258742665923046 no 865 0.259532516716473 1242 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2084 5306078 60.6385 µM 0.643087961330476 0.25928351868011 no 866 0.2600835128137 1236 679340 SGTC_3264 9137442 49.47 µM 0.642446911321294 0.259487698980792 no 867 0.260291524432856 1330 17015726 SGTC_610 4215-0184 155 µM 0.642299153709915 0.259534772906787 no 868 0.26033948183109 1316 5605015 SGTC_782 0083-0095 30.5 µM 0.640448515399422 0.260124738898411 no 869 0.260940525189813 1287 3591729 An indicator and reagent. SGTC_3304 9125678 46.087 µM 0.639673275420966 0.260372083368869 no 870 0.261192516627156 1276 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2973 9094665 17.96 µM 0.638503508999105 0.26074553280728 no 871 0.261572985289578 1314 25237061 YIL048W NEO1 SGTC_2833 9001315 45.46 µM 0.635687489220583 0.261645679782792 no 872 0.262490066174029 1320 2989378 SGTC_3248 9135562 49.47 µM 0.635503998607452 0.261704388258043 no 873 0.262549879830425 1316 17650701 SGTC_1887 st057648 70.8 µM 0.635498179267835 0.261706250287057 no 874 0.262551776913413 1291 688672 SGTC_2700 st077718 96.8 µM 0.63372263187403 0.262274694014101 no 875 0.263130926182976 1281 904970 SGTC_3276 9139060 49.47 µM 0.633657324516484 0.262295614299416 no 876 0.263152240620803 1341 4870619 SGTC_912 3474-0017 2.18 µM 0.629125588548874 0.26374937610399 no 877 0.264633419703999 1368 3360550 SGTC_780 0109-0199 192 µM 0.628554491516724 0.263932872753623 no 878 0.264820380825633 1353 610414 SGTC_2426 5582046 32.21 µM 0.627643566150823 0.264225692748382 no 879 0.265118731101703 1321 2251934 SGTC_1550 gossypolone 36.6 µM 0.626591272473081 0.264564161889568 no 880 0.265463595339409 1294 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_399 oxolinic acid 75 µM 0.625921873437143 0.264779588109727 no 881 0.265683093347222 1275 4628 A DNA gyrase inhibitor. SGTC_1054 3429-0080 167 µM 0.624410142571443 0.265266421753899 no 882 0.26617913290743 1322 1162877 SGTC_146 3448-8650 53.125 µM 0.623733489503679 0.265484476374405 no 883 0.26640131278778 1298 2891488 YIL048W NEO1 SGTC_1046 2001-0062 216 µM 0.623507015476229 0.26555747899762 no 884 0.266475696769938 1272 739778 SGTC_592 k241-0073 46.5 µM 0.620600203007875 0.266495376745416 no 885 0.267431353034678 1330 4230158 SGTC_3203 9113543 49.47 µM 0.620254675899868 0.266606974128328 no 886 0.267545064866861 1361 17018012 SGTC_1182 1222-0449 220 µM 0.618310916389293 0.267235204196479 no 887 0.268185203679613 1326 658318 SGTC_2104 5389443 200 µM 0.616840518836046 0.267710937810025 no 888 0.268669961591305 1375 2244536 SGTC_590 k048-0076 22.4 µM 0.616555070338521 0.267803341491406 no 889 0.268764118722828 1365 6832814 SGTC_633 0437-0093 97.7 µM 0.616105087795144 0.267949039773482 no 890 0.268912582182908 1319 2831118 SGTC_198 3454-2873 16.191 µM 0.614576778747459 0.268444183469973 no 891 0.269417126853348 1295 710957 SGTC_251 melphalan 456.522 µM 0.613778873840038 0.268702872485362 no 892 0.269680729719541 1387 460612 A DNA alkylator. SGTC_194 1486-1323 56.904 µM 0.612875545967305 0.268995891798741 no 893 0.269979316882262 1290 5178754 SGTC_1161 k007-0610 110 µM 0.61220635796204 0.269213064761436 no 894 0.270200617777229 1384 5843850 SGTC_990 3985-0011 41.3 µM 0.611020224810821 0.269598218983207 no 895 0.270593095533389 1321 5399565 YGL099W LSG1 SGTC_1478 0453-0656 35.7 µM 0.610215435498513 0.26985970258087 no 896 0.270859553072219 1335 5258496 SGTC_2208 7283366 200 µM 0.61012905064609 0.269887777373607 no 897 0.270888161997009 1347 898663 SGTC_3029 9088683 49.47 µM 0.60991563452759 0.269957143177164 no 898 0.270958847584965 1319 25236615 SGTC_2938 9059746 27.26 µM 0.609354408153609 0.27013959895711 no 899 0.271144775374818 1319 6471769 SGTC_2427 5545055 42.75 µM 0.60913424896113 0.270211189977259 no 900 0.271217728931325 1375 5372858 SGTC_3351 9150312 21.596 µM 0.606573788259353 0.271044492761146 no 901 0.272066899883811 1328 4904905 SGTC_1370 2001-0092 44.6 µM 0.60642654390538 0.271092452432951 no 902 0.272115773305216 1465 790957 SGTC_1821 st053465 65.6 µM 0.606083604601031 0.271204169259956 no 903 0.272229618812774 1273 675086 SGTC_1048 3161-0300 24.5 µM 0.605558262358949 0.27137535065607 no 904 0.272404062485595 1317 2165101 SGTC_891 0929-0073 133 µM 0.603527965561074 0.27203742324624 no 905 0.273078758632434 1391 5603632 SGTC_2237 6667747 47.222 µM 0.603276438924043 0.272119501073379 no 906 0.273162402093387 1344 729940 YDL015C TSC13 SGTC_2005 4024620 188 µM 0.602431414435358 0.272395338429731 no 907 0.273443502135304 1322 236743 SGTC_1651 st011928 86.1 µM 0.601865067401122 0.272580286119689 no 908 0.273631979370473 1342 720198 SGTC_3080 9117754 49.47 µM 0.600410416586849 0.273055605984279 no 909 0.27411637368704 1448 9550191 SGTC_597 k018-0003 82.8 µM 0.600057231239259 0.27317107433789 no 910 0.27423404722054 1433 6786234 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.5995541880409 0.273335578101822 no 911 0.274401693128306 1319 2374 Ca(2+)-ATPase inhibitor. SGTC_92 0063-0024 660.874 µM 0.59920972113116 0.273448252989487 no 912 0.274516520528462 1353 3594437 SGTC_215 1287-0124 461.5 µM 0.59843828005209 0.273700674215028 no 913 0.274773764941389 1390 5560863 SGTC_1078 idebenone 36.1 µM 0.597557025316641 0.273989168254687 no 914 0.275067773117653 1346 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1070 indatraline 8.81 µM 0.596018047150894 0.274493339602747 no 915 0.275581585234905 1323 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_129 0088-0017 176.636 µM 0.595802538855399 0.274563976938293 no 916 0.275653573731006 1290 182446 SGTC_2287 7945887 168.79 µM 0.594488217568977 0.27499496714992 no 917 0.276092810273476 1362 1245853 SGTC_1346 1488-2224 62.4 µM 0.594335000724462 0.275045231465235 no 918 0.276144036574295 1348 3722427 SGTC_1880 MG-132 525 µM 0.593807819746854 0.275218213013906 no 919 0.276320329143456 1320 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2134 5324836 1.464 µM 0.591800210492801 0.275877450843786 no 920 0.27699219111839 1368 699272 SGTC_657 3534-0529 86.7 µM 0.589937319571474 0.276489860674804 no 921 0.277616336448962 1418 1049549 SGTC_1027 k015-0025 8.67 µM 0.589860030204076 0.276515283303175 no 922 0.277642246413855 1324 3598955 SGTC_115 0527-0192 112.043 µM 0.588753840472437 0.276879265485316 no 923 0.278013207369589 1371 4233931 SGTC_2539 epi(13)torulosol 80 µM 0.588606975386731 0.27692760781156 no 924 0.278062476786204 1319 6708597 SGTC_3241 9133421 49.47 µM 0.586539892200576 0.277608450017887 no 925 0.27875638096767 1368 17018221 SGTC_1663 st014140 55.4 µM 0.586368706032233 0.277664870834348 no 926 0.278813884639953 1433 4207120 SGTC_1507 4075-3230 155 µM 0.586135099795161 0.277741873559674 no 927 0.278892365342635 1291 659771 SGTC_2437 5741531 144.16 µM 0.584239580490237 0.278367071630083 no 928 0.279529567762916 1471 2262990 SGTC_492 tmb-8 126 µM 0.584101989729325 0.278412479800631 no 929 0.279575848114163 1273 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_424 splitomicin 100 mM 0.583751927939718 0.278528024653663 no 930 0.27969361248814 1322 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_60 0986-0278 202 µM 0.581120451781658 0.279397342665357 no 931 0.280579637839137 1189 3110598 SGTC_1338 1486-1223 76 µM 0.580573468408644 0.279578205984378 no 932 0.280763979017022 1430 3444526 SGTC_1738 st035555 74 µM 0.579817106032754 0.279828395320333 no 933 0.281018980346772 1366 5331140 SGTC_1120 ficusin 1.78878 µM 0.579795721538664 0.279835470455693 no 934 0.281026191578784 1480 6199 A DNA cross-linker. SGTC_691 1548-0686 185 µM 0.577111725361715 0.280724168276986 no 935 0.281931991990532 1327 46495133 SGTC_2951 9072950 58.06 µM 0.577011272904643 0.28075745556674 no 936 0.281965920173711 1356 16488155 SGTC_2478 5763493 32.33 µM 0.576806463522462 0.280825329896607 no 937 0.282035101380536 1362 1365576 YLR208W SEC13 SGTC_1706 st031321 9.9705 µM 0.575195752379786 0.281359399869408 no 938 0.282579457585092 1419 6103185 SGTC_773 4358-1457 44.6 µM 0.574367836138805 0.281634106004864 no 939 0.282859456683501 1423 1186886 SGTC_2907 7721985 69.9 µM 0.57433768448212 0.281644112893379 no 940 0.282869656408815 1324 3267881 SGTC_1792 st045773 43.6 µM 0.573829371122879 0.281812840376926 no 941 0.283041635622258 1355 2919270 SGTC_1696 st025591 34.7925 µM 0.573411627786931 0.281951540870679 no 942 0.283183009562498 1390 2787147 SGTC_2986 9022445 71.43 µM 0.573224004144271 0.282013846979076 no 943 0.283246516735639 1387 6459286 SGTC_1726 st035556 14.5795 µM 0.568859601084358 0.283465047067232 no 944 0.284725711683562 1477 5919439 SGTC_2297 7971671 152.32 µM 0.567868275074132 0.283795169305172 no 945 0.285062207631498 1454 909016 SGTC_2567 aureobasidin a 60 nM 0.566842877945418 0.284136831143361 no 946 0.285410468047294 1468 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2771 fluoxetine 41.05 µM 0.56604001527629 0.284404481839124 no 947 0.285683289392937 1428 3386 A selective serotonin reuptake inhibitor. SGTC_1547 harmine 94.2 µM 0.565755395538646 0.284499394565876 no 948 0.285780036012703 1400 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1094 duloxetine 25.4 µM 0.565655356452596 0.284532758397887 no 949 0.285814044535048 1384 60834 A selective serotonin reuptake inhibitor. SGTC_170 4197-0004 226 µM 0.563763364888921 0.285164104261155 no 950 0.286457593634564 1424 218692 SGTC_373 0844-0104 25.9 µM 0.562297106457529 0.285653844369147 no 951 0.286956804724754 1407 5375804 SGTC_289 k017-0060 526 µM 0.561562276970419 0.285899432771912 no 952 0.287207144086452 1386 5512909 SGTC_698 k064-0052 127 µM 0.55889222969719 0.286792637055139 no 953 0.288117636376997 1457 5088751 SGTC_2156 5649887 115 µM 0.557503742784638 0.287257646302571 no 954 0.288591651296372 1478 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1060 3448-7350 82 µM 0.557061781708137 0.287405735480216 no 955 0.288742609233904 1475 570178 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.55639657471319 0.287628696368991 no 956 0.288969889981749 1459 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1724 st037281 8.293 µM 0.55478799950982 0.288168188489818 no 957 0.289519838184419 1394 574124 YDL195W SEC31 SGTC_2464 5717415 7.67 µM 0.554064009686645 0.288411159562409 no 958 0.289767519942923 1333 5285744 SGTC_1281 0884-0031 11.8 µM 0.55303831354788 0.288755548538339 no 959 0.29011858754834 1392 1548255 SGTC_2269 7935389 174.42 µM 0.552007844367435 0.289101734969242 no 960 0.290471489426299 1375 97605 SGTC_678 1218-2179 85.9 µM 0.549120928726302 0.290072633081126 no 961 0.29146123173194 1437 6820081 YOR116C RPO31 SGTC_1506 4226-2149 212 µM 0.548783640324204 0.290186166120766 no 962 0.291576969326766 1451 991114 SGTC_682 0kpi-0099 17 µM 0.548413940998295 0.290310632758142 no 963 0.291703853061022 1403 1714895 YML126C ERG13 SGTC_1935 st074532 41.6 µM 0.547870933537324 0.290493492345609 no 964 0.291890264161528 1499 2829742 SGTC_2097 5376186 200 µM 0.547193359899941 0.290721743116672 no 965 0.292122948779161 1452 742755 SGTC_2902 5787006 60.46 µM 0.546713873645285 0.290883315862238 no 966 0.292287660625036 1402 591003 SGTC_1158 4092-0494 91.8 µM 0.545510839481923 0.291288887589775 no 967 0.292701113766175 1505 1148199 SGTC_340 k038-0059 454 µM 0.54527072591126 0.291369867230139 no 968 0.292783667378999 1446 23733424 SGTC_3259 9138485 49.47 µM 0.544771749482215 0.291538183400697 no 969 0.292955255377016 1515 17646153 SGTC_1000 4048-0884 8.67 µM 0.544325213576552 0.291688848616443 no 970 0.293108849682981 1434 13040088 SGTC_1756 st041558 35.5 µM 0.543648784841864 0.291917150833979 no 971 0.293341591003309 1561 3955792 SGTC_446 go6976 132 µM 0.543262571225469 0.292047539534057 no 972 0.293474515337725 1434 3501 A protein kinase C inhibitor. SGTC_1013 4112-3890 241 µM 0.543261896059743 0.292047767498958 no 973 0.293474747736027 1369 705171 SGTC_294 k038-0071 157 µM 0.542796303562638 0.292204991211775 no 974 0.293635029283516 1424 24152826 SGTC_2486 5283202 22.39 µM 0.541462421012793 0.292655641533592 no 975 0.294094446364542 1361 1377751 SGTC_3319 9138450 16.7555 µM 0.541396157385215 0.292678037020913 no 976 0.294117277604508 1414 2029690 SGTC_934 2950-0684 338 µM 0.541215446957844 0.29273911677597 no 977 0.294179545836848 1521 1121253 SGTC_1220 1838-0075 193 µM 0.540170755411424 0.29309233635344 no 978 0.294539639390779 1406 5529645 SGTC_2593 nobiletin 86.24 µM 0.539593517965409 0.293287590257966 no 979 0.294738693918588 1379 72344 An anti-infammatory. SGTC_2016 5121758 140 µM 0.538133667155056 0.293781662080969 no 980 0.295242385401157 1390 2795203 SGTC_2054 5233173 129 µM 0.537793211268262 0.293896941305448 no 981 0.295359909651172 1458 6889 SGTC_3089 9117425 49.47 µM 0.537517504207887 0.29399031174206 no 982 0.295455098590289 1363 9401657 SGTC_98 0074-0023 107.663 µM 0.537081640875022 0.294137948374363 no 983 0.29560561088651 1365 3563821 SGTC_544 k015-0020 52.4 µM 0.536866017128694 0.29421099761113 no 984 0.295680083093298 1435 3008304 SGTC_2174 5790901 200 µM 0.536118221802423 0.294464401400993 no 985 0.295938423692344 1422 786020 SGTC_1343 1487-0095 224 µM 0.535370594216453 0.294717849009886 no 986 0.296196809898596 1441 4560101 YGL055W OLE1 SGTC_349 k015-0014 24 µM 0.535153139307232 0.294791585645316 no 987 0.296271983516788 1397 2196908 SGTC_2529 gangaleoidin 93.61 µM 0.535093942513014 0.294811660118264 no 988 0.296292449215546 1465 4565183 SGTC_3062 9077494 49.47 µM 0.534869579473388 0.294887750528894 no 989 0.296370022583788 1451 16459633 SGTC_2395 5646831 180.19 µM 0.534741140841177 0.294931313239575 no 990 0.296414434343805 1491 6808628 SGTC_893 0958-0369 48.9 µM 0.533062035746896 0.295501090258035 no 991 0.296995318981127 1527 6819948 SGTC_1881 5652484 16 µM 0.532329600871244 0.295749788592118 no 992 0.297248867059505 1480 2255129 SGTC_643 k048-0106 28.4 µM 0.527917453342186 0.297249964119833 no 993 0.298778315150661 1490 6763920 SGTC_2139 5578692 56.4705 µM 0.524100645514624 0.298550516481528 no 994 0.300104269804854 1464 650991 YMR113W FOL3 SGTC_2137 5261020 140 µM 0.523225113540311 0.298849212860978 no 995 0.30040880349143 1423 763655 SGTC_1383 3049-0032 20.7 µM 0.522505080869444 0.299094960821721 no 996 0.300659354889989 1533 712864 SGTC_2930 9013230 14.89 µM 0.521550658284439 0.29942084763952 no 997 0.300991612773669 1526 2995857 SGTC_2228 7354201 200 µM 0.520515387845181 0.299774521814062 no 998 0.301352202815284 1518 753451 SGTC_878 0828-0289 13.7 µM 0.519978326341023 0.299958069897816 no 999 0.301539340697406 1448 745350 YLR208W SEC13 SGTC_660 4031-1742 102 µM 0.519211272063841 0.300220309296578 no 1000 0.301806709673044 1433 6738706 SGTC_1588 farnesol 29.9 µM 0.516922844501343 0.301003288754732 no 1001 0.302605009919581 1445 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1814 st052110 31.539 µM 0.516244128246786 0.301235686608988 no 1002 0.302841956651609 1523 674163 SGTC_925 2064-1272 59.6 µM 0.515771843889617 0.301397448205966 no 1003 0.303006884912181 1437 6815817 SGTC_2321 7390090 138.78 µM 0.515727390854453 0.301412675779499 no 1004 0.303022410599136 1392 649046 SGTC_2255 7941087 197.44 µM 0.515090585858455 0.301630854002614 no 1005 0.303244860457762 1549 935561 SGTC_571 k831-0106 44.2 µM 0.514885354276556 0.301701184320622 no 1006 0.303316567873545 1535 4783639 SGTC_1936 st074407 74.3 µM 0.514839587091203 0.301716869172935 no 1007 0.303332559850277 1462 809813 SGTC_1692 fluoroquinolonic acid 71 µM 0.514785207728481 0.301735505977424 no 1008 0.303351561585159 1470 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2312 7706453 155.7 µM 0.513322026692077 0.302237159123337 no 1009 0.303863039280012 1448 976098 SGTC_36 0335-0881 14.2 µM 0.51311016201509 0.302309828159079 no 1010 0.303937131745027 1469 23828853 SGTC_1175 0741-0056 27.6 µM 0.511937319239863 0.302712251918458 no 1011 0.304347439268332 1561 765927 SGTC_714 4296-0578 26.1 µM 0.511616576347279 0.302822346430394 no 1012 0.304459690947534 1486 1589775 SGTC_1508 1080-0625 72.9 µM 0.511188438685272 0.302969331966649 no 1013 0.304609556710952 1442 767111 SGTC_309 k408-0051 1.48 µM 0.510490841655006 0.303208894972007 no 1014 0.30485381457774 1444 3640463 SGTC_1290 0986-0249 10.2 µM 0.509818920785028 0.303439720528961 no 1015 0.305089164404569 1442 53329 SGTC_1477 0139-0234 16 µM 0.509783327746698 0.303451950025291 no 1016 0.305101633621229 1500 620880 SGTC_2258 7960471 200 µM 0.509257763493142 0.303632555514787 no 1017 0.305285779510366 1425 2974708 SGTC_1909 st060837 51.5 µM 0.509240203188543 0.303638590785939 no 1018 0.305291933097204 1424 678937 SGTC_733 4069-0007 56.1 µM 0.509189005534086 0.303656187126192 no 1019 0.305309874399211 1491 5717425 YNL287W SEC21 SGTC_3196 9111891 49.47 µM 0.50864051611948 0.303844728345507 no 1020 0.305502112040424 1439 18891510 SGTC_568 1193-0097 7.48 µM 0.508587828301392 0.303862842337971 no 1021 0.305520581186343 1409 3646150 SGTC_1183 1254-0324 198 µM 0.507562649761296 0.304215392994694 no 1022 0.305880044912736 1535 5799357 SGTC_403 arphamenine a 50 µM 0.50626796800336 0.304660883793836 no 1023 0.306334273263516 1498 5487158 An arginine aminopeptidase inhibitor. SGTC_2204 7233102 200 µM 0.505816967649432 0.304816137917676 no 1024 0.306492572967217 1476 2172480 SGTC_857 0438-0306 1.35 µM 0.505579769023952 0.304897806206818 no 1025 0.306575843431638 1485 4686136 SGTC_181 1447-1644 8.07 µM 0.505034841636556 0.305085463361552 no 1026 0.306767182345322 1483 534600 SGTC_553 k007-0256 45.7 µM 0.502527793877939 0.305949477582545 no 1027 0.307648153259993 1510 6287000 SGTC_1805 st050013 60.3 µM 0.499948183079435 0.306839628024276 no 1028 0.308555781903375 1515 4037144 SGTC_3110 9122132 49.47 µM 0.499816144509289 0.306885221501942 no 1029 0.30860227084433 1558 918317 SGTC_401 neomycin 50 µM 0.499387688572922 0.307033189722787 no 1030 0.308753145338085 1469 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1787 fluconazole 80 µM 0.498302152790513 0.30740822261364 no 1031 0.309135545366404 1411 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_3184 9108758 49.47 µM 0.49665472147449 0.307977764973766 no 1032 0.309716278634093 1495 902885 SGTC_1960 st011366 51.8 µM 0.495352561776523 0.308428269212666 no 1033 0.31017563719264 1483 3972846 SGTC_3121 9125696 49.47 µM 0.49461643929182 0.308683071017474 no 1034 0.310435447855556 1538 1235365 SGTC_1662 st014054 52 µM 0.494498201177376 0.308724006608842 no 1035 0.310477188214664 1464 2838777 SGTC_985 1493-0307 8.71 µM 0.492004441428761 0.30958793211481 no 1036 0.311358101882348 1556 3278274 SGTC_120 rhodamine 6G 52.259 µM 0.491455271221399 0.30977832552778 no 1037 0.311552240175528 1466 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2231 micatex 6.853 µM 0.491427537320134 0.309787942028811 no 1038 0.311562045834617 1518 20737 An antifungal of unknown mechanism. SGTC_2956 9076196 2.52 µM 0.491310539673076 0.309828511428722 no 1039 0.311603413250888 1514 16423868 SGTC_2669 eugenol 100 µM 0.491157740306293 0.309881498705263 no 1040 0.311657442832735 1526 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_824 1304-0008 100 µM 0.490172024152912 0.31022341709327 no 1041 0.312006087709475 1504 768245 SGTC_3205 9113483 49.47 µM 0.48928067183889 0.310532744528214 no 1042 0.312321501455733 1623 17018033 SGTC_959 1222-0044 107 µM 0.488674116065057 0.310743315206321 no 1043 0.31253621583868 1546 6083612 SGTC_1625 st003711 30.1 µM 0.487513290608614 0.311146477873962 no 1044 0.312947313302167 1570 24207034 YER133W GLC7 SGTC_145 3737-0113 38.366 µM 0.486139656000618 0.311623843464339 no 1045 0.313434076084084 1524 6849351 SGTC_867 0518-0118 155 µM 0.486010107340941 0.311668880581356 no 1046 0.313479999890087 1520 6848158 SGTC_406 estrone 100 µM 0.485053524038686 0.312001520430137 no 1047 0.313819189319933 1612 5870 A steroid. SGTC_1768 st044301 37.178 µM 0.481631957000084 0.313192581386341 no 1048 0.31503371016779 1472 3931349 SGTC_3288 9119690 36.221 µM 0.480280326815992 0.313663627630927 no 1049 0.315514037920855 1457 17595618 YKL019W RAM2 SGTC_71 0417-1750 47.813 µM 0.48001854940933 0.313754892821454 no 1050 0.315607101627181 1647 6811472 SGTC_269 exalamide 29 µM 0.479682618189089 0.313872027444942 no 1051 0.315726544667673 1551 3316 A derivative of salicylamide. SGTC_1186 1319-0216 26 µM 0.479197360426475 0.314041263312526 no 1052 0.315899115940445 1627 4565136 SGTC_2035 5154463 94.595 µM 0.477344800114944 0.314687711676964 no 1053 0.316558307158821 1570 2769623 SGTC_1505 k297-0037 20.6 µM 0.476974747227284 0.314816909291927 no 1054 0.316690051952849 1484 4089396 SGTC_539 4859-0462 2.54 µM 0.475778747500337 0.315234627035657 no 1055 0.31711600610832 1617 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2868 9035608 32.47 µM 0.475252611882046 0.315418461311562 no 1056 0.317303465620304 1483 6462614 SGTC_459 nigericin 15.3 µM 0.474425794956524 0.315707447387424 no 1057 0.317598151097597 1543 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_333 3486-0131 40.1 µM 0.472624024600428 0.316337585926171 no 1058 0.318240719602478 1622 6744690 SGTC_1949 st076024 69.1 µM 0.472613038267256 0.316341429848082 no 1059 0.318244639358412 1466 2921930 SGTC_2612 dictamnine 15.46 µM 0.471870021772583 0.316601444095698 no 1060 0.318509783514191 1525 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1029 k015-0030 64.7 µM 0.469848169855393 0.317309437953584 no 1061 0.319231748290381 1570 2208316 SGTC_2096 5468907 200 µM 0.46955447125564 0.317412338389473 no 1062 0.319336679592375 1630 759785 SGTC_844 0330-0132 15.3 µM 0.468113574961021 0.317917376104339 no 1063 0.319851686006116 1583 2828079 SGTC_2296 7971656 126.45 µM 0.467269411485244 0.318213414974183 no 1064 0.320153569132789 1509 666570 SGTC_876 0720-0963 56.8 µM 0.466831874538928 0.318366900098153 no 1065 0.320310084540967 1646 765861 SGTC_2492 derrusnin 100 µM 0.466458587726331 0.318497871344147 no 1066 0.320443641712203 1475 1715307 Part of coumarin class of compounds. SGTC_3318 9139014 38.6185 µM 0.463889295404044 0.319399946776489 no 1067 0.321363531284105 1534 16643984 SGTC_462 ag-879 158 µM 0.463353614227447 0.319588158762217 no 1068 0.321555460799064 1607 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_606 k015-0008 38.6 µM 0.463154515303361 0.319658124169605 no 1069 0.321626808213707 1637 1970475 SGTC_1688 st021091 57.6 µM 0.460008294264924 0.32076458931687 no 1070 0.322755133524874 1638 3656366 SGTC_1022 4477-0945 21.3 µM 0.459890053299202 0.320806203520677 no 1071 0.322797570051557 1519 4648966 SGTC_694 1315-0438 43.2 µM 0.459390387971997 0.320982082614501 no 1072 0.322976924753659 1590 6793154 SGTC_2101 5377231 179.231 µM 0.459311993202689 0.321009680733781 no 1073 0.323005068267548 1627 2844213 SGTC_2157 5649910 96.377 µM 0.45869813867742 0.32122581645058 no 1074 0.323225475435599 1489 2858091 SGTC_3214 9129694 49.47 µM 0.458329834962398 0.321355523787479 no 1075 0.323357746301519 1649 17158655 SGTC_3230 9131665 49.47 µM 0.453668691672753 0.322998940048667 no 1076 0.32503365218471 1542 15943720 SGTC_3084 9116877 49.47 µM 0.452058818811081 0.323567351625465 no 1077 0.325613304853649 1576 27241325 SGTC_2205 7238770 200 µM 0.450611503500318 0.324078719313225 no 1078 0.326134787132566 1586 279867 SGTC_491 tetrandrine 80.3 µM 0.450250957540952 0.324206159679108 no 1079 0.326264748437553 1604 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1079 idarubicin 2.36 µM 0.448662205572417 0.324767973050606 no 1080 0.326837676311908 1565 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_861 0443-0273 110 µM 0.447215767481454 0.325279808419021 no 1081 0.327359638972344 1582 6149169 SGTC_1248 0469-0687 58.6 µM 0.446367319803974 0.325580192926225 no 1082 0.327665967614344 1628 4017482 SGTC_1024 4507-0395 26 µM 0.445058459920398 0.326043803995642 no 1083 0.328138753748637 1585 4201836 SGTC_1591 genipin 88.4 µM 0.444491667443788 0.326244650995114 no 1084 0.328343575943716 1623 442424 A DNA cross-linking agent. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.443698555304137 0.326525780599995 no 1085 0.32863027005566 1589 688664 SGTC_2884 9058502 51.95 µM 0.443653625638152 0.326541709494718 no 1086 0.328646514249114 1529 6471554 SGTC_1380 2291-0730 164 µM 0.442740664606335 0.326865449638821 no 1087 0.328976662824764 1532 2999191 SGTC_3271 9137798 49.47 µM 0.442192566573627 0.327059870344549 no 1088 0.329174932334715 1658 6498326 SGTC_466 geldanamycin 89.2 µM 0.438849558926763 0.328246712905732 no 1089 0.330385273873215 1607 5288382 HSP90 inhibitor. SGTC_2311 7694451 200 µM 0.438093826160996 0.328515255930867 no 1090 0.330659134841953 1631 2163142 SGTC_2877 9040724 71.43 µM 0.437145166134672 0.328852479380661 no 1091 0.331003036766985 1674 6463895 SGTC_2707 st078556 66.6 µM 0.437096566949364 0.328869758855857 no 1092 0.331020658463658 1686 17250899 SGTC_649 1123-0311 367 µM 0.436963226792833 0.328917169922602 no 1093 0.331069008517328 1591 693629 YIL048W NEO1 SGTC_1775 st081588 35.1725 µM 0.435588054658926 0.329406293211932 no 1094 0.331567819572059 1556 1426443 YGL099W LSG1 SGTC_1863 st057641 20.1 µM 0.434601047447848 0.329757533511268 no 1095 0.331926017299483 1592 3921635 SGTC_18 0111-0177 500 nM 0.434355383570149 0.329844979787448 no 1096 0.332015195806309 1609 721752 SGTC_1114 scopoletin 1.73284 µM 0.433158360966276 0.330271203787558 no 1097 0.332449863360365 1676 5280460 A coumarin with genotoxic properties. SGTC_929 2805-0021 398 µM 0.432292299098873 0.330579719962633 no 1098 0.332764491735914 1629 3098024 SGTC_1074 carmofur 3.8 µM 0.431830152665495 0.330744396963503 no 1099 0.332932431405337 1590 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1136 pergolide 1.05886 µM 0.429539970908559 0.331560942180229 no 1100 0.333765155976651 1588 47811 A dopamine receptor agonist. SGTC_588 3970-1144 52.9 µM 0.429379235381898 0.331618281223272 no 1101 0.333823631251532 1636 1888707 SGTC_509 pifithrin 175 µM 0.42804010463861 0.33209614142005 no 1102 0.334310961196447 1640 4817 A p53 inhibitor. SGTC_2233 sulbentine 40.3845 µM 0.42679975330362 0.33253899655376 no 1103 0.334762593097434 1567 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.42641900610073 0.332674985498548 no 1104 0.334901277286333 1711 6728940 SGTC_2067 5224629 34.075 µM 0.424854686715024 0.333233933961929 no 1105 0.335471304516472 1557 2835000 SGTC_218 alverine citrate 93.75 µM 0.423717088018527 0.333640643272057 no 1106 0.335886075731316 1638 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1090 efavirenz 20.7 µM 0.423380873831932 0.333760882561228 no 1107 0.336008698535416 1636 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1737 st035557 69.7 µM 0.423295497136836 0.333791418295913 no 1108 0.336039839589925 1540 5716916 SGTC_157 1348-1695 65.819 µM 0.42278867328983 0.333972711011784 no 1109 0.336224726188508 1575 5380510 SGTC_3220 9131269 49.47 µM 0.421368497530297 0.334480919326102 no 1110 0.336743009563606 1589 17722206 SGTC_2273 7815444 169.05 µM 0.421316976729535 0.334499361696827 no 1111 0.336761817562267 1726 2824616 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.419937576839323 0.334993279641349 no 1112 0.337265527997633 1555 6708561 SGTC_192 3455-0609 60.9 µM 0.419667918908542 0.335089868708293 no 1113 0.337364032132287 1623 3769639 SGTC_2018 5133068 143 µM 0.419422379820193 0.335177828108058 no 1114 0.337453735521521 1571 785362 SGTC_1075 aripiprazole 15.2 µM 0.418453595849956 0.335524963467014 no 1115 0.337807753805632 1587 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2640 pentamidine 10.38 µM 0.418379547482357 0.33555150231172 no 1116 0.337834818869736 1723 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1785 bathophenanthroline 24 µM 0.417844878219571 0.335743151465628 no 1117 0.338030268148291 1537 72812 An iron chelator. SGTC_2448 5185112 27.17 µM 0.417415225546552 0.335897188988041 no 1118 0.338187360078301 1583 5718189 SGTC_1849 st056239 19.2 µM 0.417295862160531 0.335939987612155 no 1119 0.338231007366115 1496 5393181 SGTC_3266 9136860 49.47 µM 0.416840361172994 0.336103330402609 no 1120 0.338397589159356 1574 4871271 YPR165W RHO1 SGTC_1115 galangin 695.678 nM 0.416632747813306 0.336177790886629 no 1121 0.338473526177618 1665 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3135 9127742 49.47 µM 0.416015309748786 0.336399272882068 no 1122 0.338699400188148 1590 3643468 SGTC_672 1441-0018 53.7 µM 0.411419447717857 0.338049640309794 no 1123 0.340382498019683 1571 251141 SGTC_529 4076-0302 30.3 µM 0.411033872917574 0.338188241837392 no 1124 0.340523848571383 1590 5816522 SGTC_1500 4488-1866 171 µM 0.410419256034859 0.338409221839967 no 1125 0.340749211567229 1700 2900003 SGTC_1164 k060-0068 93.7 µM 0.409645791580221 0.338687393159204 no 1126 0.341032900356757 1626 5963676 SGTC_278 4092-0821 23.9 µM 0.409223481667368 0.33883931125351 no 1127 0.341187831771726 1653 877900 SGTC_86 0417-1630 471.922 µM 0.40868501788606 0.339033051554059 no 1128 0.341385414999769 1631 3634867 SGTC_2735 sertaconazole 140 nM 0.40764335125061 0.339407966024756 no 1129 0.341767766243317 1686 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2761 levamisole 97.89 µM 0.406779836992702 0.339718880831038 no 1130 0.342084848494888 1736 26879 An alkaline phosphatase inhibitor. SGTC_2595 hexamethylquercetagetin 100 µM 0.40622042472461 0.339920359668717 no 1131 0.34229032403262 1622 386331 SGTC_1650 st011916 45.8 µM 0.405957548946892 0.340015053237103 no 1132 0.342386896040363 1712 242528 SGTC_790 1575-0012 79.1 µM 0.405924044722526 0.340027122912221 no 1133 0.342399205142906 1671 378741 YLR208W SEC13 SGTC_552 k242-0005 476 µM 0.404970110875991 0.340370840015658 no 1134 0.342749740681194 1632 4088318 SGTC_1226 3909-7979 35.4 µM 0.404332068641521 0.340600810544874 no 1135 0.342984273300509 1727 6615510 SGTC_408 cantharidin 100 µM 0.403537036309934 0.340887448186296 no 1136 0.343276597268276 1636 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2905 7799065 20.05 µM 0.400440009017593 0.342004912260064 no 1137 0.344416230471428 1717 1296806 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.399015207372092 0.342519472645943 no 1138 0.344940999490561 1682 676296 Flavone; oxidizing agent. SGTC_1103 duloxetine 36.1 µM 0.398784290688212 0.342602894675868 no 1139 0.345026076592728 1736 60835 A selective serotonin reuptake inhibitor. SGTC_2506 ethyl hematommate 54.16 µM 0.398578151081354 0.342677372110484 no 1140 0.345102031645148 1550 3940691 An allergen. SGTC_1299 1079-1439 3.74 µM 0.395814576275782 0.343676430463067 no 1141 0.346120911440751 1587 323161 SGTC_1996 st072960 66.8 µM 0.395034068818219 0.343958789478913 no 1142 0.346408872581395 1740 1719405 SGTC_2817 7995342 71.43 µM 0.394814713311478 0.34403815994381 no 1143 0.346489817795753 1542 18879975 SGTC_521 r062-0005 13.8 µM 0.39479891273729 0.344043877407432 no 1144 0.346495648696773 1608 2832033 SGTC_1139 k015-0024 46.9 µM 0.394779746332836 0.3440508128501 no 1145 0.34650272174218 1734 2766652 SGTC_957 1187-1561 14.1 µM 0.393753044625676 0.344422405728919 no 1146 0.346881687234431 1624 1538454 SGTC_1025 k007-0731 70 µM 0.392203091759536 0.344983662722467 no 1147 0.347454079938634 1610 6256118 SGTC_822 1487-0950 154 µM 0.392136570082523 0.345007758685229 no 1148 0.347478653982123 1724 1958375 SGTC_2731 amoxapine 43.43 µM 0.392032783689629 0.345045354198034 no 1149 0.347516995416233 1738 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2666 tannic acid 100 µM 0.392015278365195 0.345051695465688 no 1150 0.347523462499088 1676 16134267 A thiamine antagonist. SGTC_639 0833-0042 114 µM 0.390778278564354 0.345499906177376 no 1151 0.347980566027805 1606 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2474 5321570 43.32 µM 0.389971385435249 0.345792390185025 no 1152 0.348278853119806 1728 2841384 SGTC_3037 9091026 49.47 µM 0.389083807838244 0.34611422716002 no 1153 0.348607075548709 1667 25236398 YIL048W NEO1 SGTC_2826 7992541 19.48 µM 0.388916383837736 0.346174947825826 no 1154 0.34866900094956 1682 2985066 SGTC_2591 skatole 100 µM 0.388030181074273 0.346496418128483 no 1155 0.348996849403357 1640 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2875 9039966 71.43 µM 0.387762463738003 0.346593554429086 no 1156 0.349095912936605 1748 6463691 SGTC_2978 9011784 42.97 µM 0.387642783561752 0.346636981438011 no 1157 0.349140201558015 1823 2994934 SGTC_1140 3229-1848 2.98 µM 0.387232463152121 0.346785885119268 no 1158 0.349292059553849 1729 2849525 SGTC_530 4358-1714 28 µM 0.386932313293756 0.346894823326901 no 1159 0.349403159138018 1713 1564641 SGTC_2655 perillic acid 100 µM 0.386541030348198 0.347036856933552 no 1160 0.3495480107393 1623 5702197 An apoptosis inducer. SGTC_3257 9139206 32.98 µM 0.385897934946251 0.347270343791763 no 1161 0.34978613003512 1710 4910041 SGTC_274 sirtinol 40.1 µM 0.385386969067691 0.347455900089772 no 1162 0.349975367796518 1588 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_661 1304-0007 33.6 µM 0.384985646874859 0.347601665127171 no 1163 0.350124024819475 1619 3117130 SGTC_2872 9044037 25.97 µM 0.38449035214348 0.347781593184969 no 1164 0.350307522641116 1733 6465195 SGTC_2673 kobusone 100 µM 0.38322188201755 0.348242552592281 no 1165 0.350777627361108 1717 6710676 An epoxy ketone and protein crosslinker. SGTC_449 xestospongin c 11.1929 µM 0.383094640799241 0.348288804174357 no 1166 0.350824796553753 1707 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2940 9060638 45.86 µM 0.382791766163428 0.348398906750421 no 1167 0.350937083508614 1671 4027022 SGTC_2229 7354935 190 µM 0.382439172630558 0.348527099493413 no 1168 0.351067819517706 1696 318112 SGTC_2929 9013348 24.6 µM 0.38168557208138 0.348801144700555 no 1169 0.35134730156818 1651 2995952 SGTC_330 1488-0319 80.1 µM 0.381378715249158 0.348912755135749 no 1170 0.351461126248123 1678 6846614 SGTC_2773 thioridazine 9.09 µM 0.380289501241109 0.349309031223089 no 1171 0.35186526397869 1670 5452 An antipsychotic. SGTC_2908 7930301 100 µM 0.379654439949954 0.349540154065911 no 1172 0.352100971947605 1573 2223178 SGTC_687 k029-0044 34.9 µM 0.379388127330707 0.349637091916093 no 1173 0.35219983288016 1786 5829338 SGTC_2524 avocatin b 10.57 µM 0.378051911336359 0.350123622728168 no 1174 0.352696015473143 1751 6710748 SGTC_2203 7227154 166.4 µM 0.378046740494156 0.350125505966723 no 1175 0.352697936070762 1673 896304 SGTC_496 calpeptin 138 µM 0.377203387320312 0.350432707392509 no 1176 0.353011231596261 1611 73364 A calpain inhibitor. SGTC_3160 9100216 49.47 µM 0.37503785736375 0.351221975282758 no 1177 0.353816155973654 1668 17191039 SGTC_3043 9092303 49.47 µM 0.374164156965228 0.351540593723889 no 1178 0.354141094497033 1583 25236084 SGTC_2459 5811157 9.22 µM 0.37408247877976 0.351570385215595 no 1179 0.354171476921434 1651 2870684 YBR192W RIM2 SGTC_736 0958-0254 92.6 µM 0.372138113809429 0.352279846228117 no 1180 0.354895010093127 1718 6812352 SGTC_955 1216-0110 33 µM 0.371360304665749 0.352563797854617 no 1181 0.355184593651482 1595 3619719 SGTC_999 SEC7.066 22.7 µM 0.370782271393965 0.352774871350982 no 1182 0.35539985350838 1722 740511 YDR170C SEC7 SGTC_1154 4088-0362 150 µM 0.368848743633398 0.353481243620513 no 1183 0.356120235090038 1638 6618304 SGTC_1021 4476-0760 85.3 µM 0.365299316367133 0.354779262366542 no 1184 0.357443994329757 1625 746768 SGTC_3 0833-0587 95.581 µM 0.364340164180356 0.355130312776628 no 1185 0.357802005600208 1697 5382644 SGTC_1990 st072050 59.8 µM 0.364172184348642 0.355191806184328 no 1186 0.357864718308325 1640 17233948 SGTC_2693 st077581 40.7 µM 0.364040437089561 0.355240038350759 no 1187 0.357913906822607 1703 25238761 SGTC_6 0844-0013 19.835 µM 0.362962469822046 0.355634765088806 no 1188 0.358316459980873 1750 1584900 SGTC_738 1315-0003 72.4 µM 0.36292122959026 0.35564986938838 no 1189 0.358331863751928 1763 6251474 SGTC_2416 tofa 880 nM 0.362447858098075 0.355823258666956 no 1190 0.358508690759357 1567 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2047 4141938 200 µM 0.361829840592027 0.356049674624846 no 1191 0.358739595665457 1697 3807862 SGTC_2442 5158906 48.48 µM 0.360805608698398 0.356425022438444 no 1192 0.359122384854849 1775 1893835 SGTC_2663 amphotericin b 100 µM 0.360577937476248 0.356508475478805 no 1193 0.359207492321161 1694 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_72 0744-0168 198.391 µM 0.360508817676912 0.356533812747742 no 1194 0.359233331888228 1724 677577 SGTC_3114 9122766 49.47 µM 0.360332276238039 0.35659853047821 no 1195 0.359299332605538 1637 17176985 SGTC_63 0099-0242 26.702 µM 0.358370438760234 0.357317991360138 no 1196 0.36003305550033 1770 3898502 YLR359W ADE13 SGTC_523 1934-0222 13.7 µM 0.356190488635659 0.358118035518578 no 1197 0.360848957219959 1657 1361595 SGTC_1801 st050089 28.441 µM 0.356127385898623 0.358141203595319 no 1198 0.360872584477288 1673 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_805 3852-0218 479 µM 0.355287329379753 0.358449678841469 no 1199 0.3611871733917 1650 6615355 SGTC_1240 0356-0016 42.1 µM 0.354560390999218 0.358716690809715 no 1200 0.36145947701059 1723 4305613 SGTC_1276 0871-0068 94.2 µM 0.354469111344716 0.358750223652026 no 1201 0.361493674390579 1762 3414906 SGTC_2887 9044784 58.44 µM 0.35108465499892 0.359994317054525 no 1202 0.36276241983206 1697 6465546 SGTC_2420 aureobasidin a 50 nM 0.349751892460157 0.360484635814228 no 1203 0.363262452825156 1835 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_595 3909-8003 73.7 µM 0.349223322146659 0.360679158621477 no 1204 0.363460829278036 1724 699517 SGTC_1898 st060199 18.6 µM 0.348808655960655 0.360831788025064 no 1205 0.363616482283477 1670 688866 SGTC_2831 7999036 19.48 µM 0.34668791889939 0.361612730312775 no 1206 0.364412893649632 1870 2988270 SGTC_2286 7945697 125 µM 0.344746276845049 0.362328228400086 no 1207 0.365142562270029 1627 1245733 SGTC_2846 9008642 19.48 µM 0.3446106503939 0.362378224965253 no 1208 0.365193548942192 1685 2992898 SGTC_1818 st052136 56.3 µM 0.340346154527382 0.363951457783577 no 1209 0.366797931593003 1654 674169 SGTC_1460 k062-0059 9.15 µM 0.339939492369938 0.364101601525785 no 1210 0.366951047569609 1657 1373085 SGTC_2838 9002687 71.43 µM 0.338381299628224 0.364677094826833 no 1211 0.367537932294185 1649 6457060 SGTC_601 0986-0029 62.9 µM 0.337994438445293 0.364820023076073 no 1212 0.367683689442947 1717 24747981 SGTC_1334 1486-0610 236 µM 0.335893037651193 0.365596726304545 no 1213 0.368475763749271 1759 3742339 SGTC_264 promethazine 12.5 mM 0.335786874861769 0.365635980017616 no 1214 0.36851579421845 1799 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1241 0364-0022 50.8 µM 0.334852340708598 0.365981584880215 no 1215 0.368868237599438 1766 4563895 SGTC_393 acivicin 6.25 µM 0.334333403049196 0.366173542863325 no 1216 0.369063993606353 1727 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_559 1550-0661 158 µM 0.332593805122169 0.366817274106536 no 1217 0.369720460101052 1771 5830875 SGTC_2606 farnesol 9.78 µM 0.332229245535575 0.36695222547421 no 1218 0.369858080995582 1824 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2053 5265679 138 µM 0.328424078047544 0.368361787449536 no 1219 0.371295520035534 1674 764595 SGTC_677 0929-0063 136 µM 0.328040223573904 0.368504078845269 no 1220 0.371440624916036 1708 1539583 SGTC_750 4073-0104 132 µM 0.327611074673461 0.368663181827851 no 1221 0.371602873654099 1731 22330957 SGTC_2438 5259590 200 µM 0.326851875152195 0.368944703157469 no 1222 0.371889960808343 1859 1201127 SGTC_1165 k072-0275 30.3 µM 0.325830408608064 0.369323587546384 no 1223 0.372276335197512 1791 6153523 YGL055W OLE1 SGTC_3191 9110352 49.47 µM 0.324742827544485 0.3697271348204 no 1224 0.372687859070169 1752 17122424 SGTC_3181 9108277 49.47 µM 0.324562756934617 0.369793963933678 no 1225 0.372756009045683 1705 17097298 SGTC_1911 st060208 74.3 µM 0.323352746688671 0.370243133639851 no 1226 0.373214055774087 1827 688783 SGTC_444 curcumin 90.4 µM 0.321254745721271 0.371022354913429 no 1227 0.374008673936243 1778 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2723 salbutamol 83.58 µM 0.320801554655399 0.371190744802502 no 1228 0.374180390586823 1827 9884233 β2-adrenoceptor agonist SGTC_2989 9073649 71.4286 µM 0.320142330756115 0.371435733281536 no 1229 0.374430218804012 1895 21367202 SGTC_3307 9126885 69.2785 µM 0.319911084482369 0.371521684067283 no 1230 0.374517867451528 1673 24824909 SGTC_1443 4112-3303 14 µM 0.319202658166495 0.371785035404265 no 1231 0.374786420697835 1739 704433 SGTC_864 0469-0573 172 µM 0.316458605450198 0.372805678560816 no 1232 0.375827219971804 1707 689425 SGTC_1471 k673-0312 37 µM 0.316173922589731 0.372911616880999 no 1233 0.375935250004037 1856 24099884 SGTC_131 0141-0277 33.849 µM 0.315719603198694 0.373080701524816 no 1234 0.376107672999855 1843 1547771 SGTC_191 3914-0123 66.505 µM 0.315014195149937 0.373343282604357 no 1235 0.376375438001287 1721 3144412 SGTC_1100 amiodarone 5.07 µM 0.314047728621843 0.373703135579176 no 1236 0.376742394472768 1915 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1429 4049-0205 9.46 µM 0.313875366331169 0.373767324326431 no 1237 0.376807850209672 1778 22774478 SGTC_2168 5727979 200 µM 0.313080293680398 0.37406345943475 no 1238 0.377109830201571 1728 695210 SGTC_1857 st056007 79.3 µM 0.31169739064348 0.374578716592307 no 1239 0.377635255600967 1880 619834 SGTC_2472 5377652 49.4 µM 0.311008782291936 0.374835369443732 no 1240 0.37789697259797 1738 1610903 SGTC_1485 3909-9022 254 µM 0.308203788383467 0.375881397189112 no 1241 0.378963634987944 1849 714516 SGTC_1412 3909-8563 178 µM 0.307953446934774 0.375974798054523 no 1242 0.379058877941027 1885 23767530 SGTC_742 0kpi-0133 140 µM 0.306760982299761 0.376419798976207 no 1243 0.37951265442493 1899 2728852 SGTC_567 1080-0542 68.4 µM 0.305622886050225 0.37684466409679 no 1244 0.379945896595273 1886 5950415 SGTC_2268 7933382 153.85 µM 0.30384415732356 0.377508983702706 no 1245 0.380623311726409 1839 935025 YOR257W CDC31 SGTC_1948 st076329 66.6 µM 0.303697325196632 0.377563838791855 no 1246 0.380679248000208 1808 24208413 SGTC_703 3875-0075 71.8 µM 0.301586314490813 0.378352764854969 no 1247 0.381483720981858 1799 2850814 SGTC_1972 st070201 17.4 µM 0.300345031756295 0.378816893640071 no 1248 0.381956993716081 1891 2829099 SGTC_3174 9107204 49.47 µM 0.299936282258101 0.378969767707165 no 1249 0.382112879213684 1848 3938802 SGTC_300 r073-0011 5.04 µM 0.297263963460627 0.379969691940747 no 1250 0.383132495878729 1859 2735780 SGTC_2482 5981709 142.65 µM 0.296968059628511 0.380080462290156 no 1251 0.383245447207981 1806 877755 SGTC_3148 9097893 49.47 µM 0.294902686503745 0.380853899495195 no 1252 0.384034109817179 1653 17174100 SGTC_920 mycophenolic acid 780.421 nM 0.293924912677459 0.381220220800359 no 1253 0.384407640469703 1748 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1712 st032288 53.4 µM 0.292335511281926 0.381815914379658 no 1254 0.385015054987291 1793 2883011 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.291740491525346 0.382038994618553 no 1255 0.385242523759851 1840 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2224 6650123 117.647 µM 0.291188757889773 0.382245881358526 no 1256 0.385453480064915 1808 2908370 SGTC_1003 4049-0218 100 µM 0.288828982996414 0.383131118498262 no 1257 0.386356125831259 1863 295161 SGTC_1041 0206-0046 107 µM 0.288449428188318 0.383273560400316 no 1258 0.386501368246259 1787 50494 SGTC_2390 9097792 176.6 µM 0.288438499396207 0.383277662065362 no 1259 0.386505550550262 1723 4497149 SGTC_1253 0550-0034 176 µM 0.286055926476965 0.384172172769696 no 1260 0.38741764359751 1795 5969915 SGTC_2760 etidronate 98.04 µM 0.28600047799421 0.384192997658969 no 1261 0.387438877726632 1771 3305 A chelator and antioxidant. SGTC_2946 9065502 71.43 µM 0.285661443613562 0.384320336698047 no 1262 0.387568719075701 1817 16489101 SGTC_116 0155-0182 31.788 µM 0.284561572207616 0.384733526909265 no 1263 0.387990027718253 1786 771486 SGTC_2278 7948257 134.34 µM 0.284433449252576 0.384781667561855 no 1264 0.388039114139251 1975 1247028 SGTC_2180 6301957 200 µM 0.283699444651063 0.385057495143061 no 1265 0.388320360178487 1927 845462 SGTC_823 0417-1665 178 µM 0.280292979836787 0.386338351318363 no 1266 0.389626368146695 1836 3429856 SGTC_2813 7971799 71.43 µM 0.279978668207682 0.386456597509819 no 1267 0.389746935478396 1827 2234054 SGTC_3120 9124077 49.47 µM 0.279642470402074 0.386583089102323 no 1268 0.389875909909861 1919 18774327 YGL155W CDC43 SGTC_3072 9116419 49.47 µM 0.279244795979641 0.386732726311721 no 1269 0.390028484062561 1769 17170162 SGTC_2279 7948423 32.93 µM 0.277803819188165 0.387275078982919 no 1270 0.390581479627814 1971 1247112 SGTC_3338 9144300 39.5675 µM 0.276522377818092 0.387757570898032 no 1271 0.391073437213975 1873 4901274 SGTC_1570 verbenone 133 µM 0.276121168331997 0.387908671096126 no 1272 0.391227501244646 1960 29025 A natural terpanoid with antifungal properties. SGTC_2289 7946404 165.07 µM 0.275889373280819 0.387995975568438 no 1273 0.391316518086942 1785 1246120 YPR165W RHO1 SGTC_1310 1188-0297 994 nM 0.274279771992945 0.38860237994691 no 1274 0.391934814135661 1868 1588352 SGTC_2737 bleomycin 30.5 nM 0.274120572173365 0.388662371985014 no 1275 0.391995982414698 1836 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_510 ag-490 170 µM 0.274094116716857 0.388672341580011 no 1276 0.392006147476031 1952 5328779 SGTC_3258 9138477 49.47 µM 0.274042305899292 0.388691866417429 no 1277 0.392026055119168 1851 4970355 SGTC_3036 9090181 49.47 µM 0.273733298126948 0.3888083214219 no 1278 0.392144793266842 1826 25236586 SGTC_173 1273-0061 2.693 µM 0.272057744011961 0.389439957144754 no 1279 0.392788809917151 1746 2847414 YPL266W DIM1 SGTC_167 3672-0051 66.205 µM 0.271141595236332 0.389785442561163 no 1280 0.393141065505166 1786 3237971 SGTC_1903 st060211 78.3 µM 0.268309370937717 0.390854041732322 no 1281 0.394230596815177 1945 688960 SGTC_1422 4031-0024 15.5 µM 0.267775481302842 0.391055571096502 no 1282 0.394436072401597 1927 782427 SGTC_2628 lathosterol 100 µM 0.266058956110175 0.391703712429323 no 1283 0.395096902151021 1835 6710616 SGTC_503 tyrphostin 8 294 µM 0.265442705229627 0.391936475544567 no 1284 0.395334220825102 1944 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1187 1391-0724 117 µM 0.26439893077011 0.392330806096788 no 1285 0.395736267671373 1866 6997986 SGTC_1016 4226-1401 38 µM 0.263678531223429 0.39260303243715 no 1286 0.396013819921715 1917 2901613 SGTC_727 3032-0951 202 µM 0.262583602664296 0.393016887310997 no 1287 0.39643576992797 1867 3652836 SGTC_2869 9037858 32.47 µM 0.262444404548648 0.393069509298915 no 1288 0.396489421076453 1873 27187042 SGTC_144 4161-2749 112.381 µM 0.261988761959508 0.393241772553703 no 1289 0.396665053164263 1889 797501 YMR168C CEP3 SGTC_2251 lansoprazole 556 µM 0.261601313612515 0.393388270288452 no 1290 0.396814415581325 1767 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_347 4534-1311 26.2 µM 0.259841466458827 0.394053874171475 no 1291 0.397493031808424 1825 2862016 SGTC_488 nitrendipine 139 µM 0.259039483262338 0.39435730054654 no 1292 0.397802388334374 1912 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.257452853100884 0.394957782957081 no 1293 0.398414603303768 1917 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1215 3852-0577 11.2 µM 0.256204048367718 0.395430586212999 no 1294 0.398896641395257 1948 2884876 SGTC_2708 st078559 56 µM 0.255432139085791 0.395722911682044 no 1295 0.399194675232459 1927 17250902 SGTC_1892 st058411 7.36 µM 0.253897019033419 0.396304442660686 no 1296 0.399787558908559 1957 3934738 SGTC_954 1189-0853 2.85 µM 0.253431345546864 0.39648089380361 no 1297 0.39996745392083 1936 2828194 SGTC_2736 butenafine 14.65 µM 0.253330564696431 0.396519084074359 no 1298 0.400006389515951 1930 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_963 1269-2853 151 µM 0.252239437170047 0.396932623490967 no 1299 0.400427998438463 1787 3668223 SGTC_2187 6125751 200 µM 0.251808662166243 0.397095919984498 no 1300 0.400594480792095 1889 874498 SGTC_3251 9135047 49.47 µM 0.250964523634875 0.397415964991269 no 1301 0.40092076879872 1967 17682963 SGTC_642 0335-0876 158 µM 0.249432147081248 0.397997123567095 no 1302 0.401513260510204 1863 6812350 SGTC_59 0330-0160 1.33 µM 0.248616767507488 0.398306451171185 no 1303 0.401828618538181 1908 4293482 SGTC_2597 laccaic acid a 100 µM 0.24853038208277 0.39833922664553 no 1304 0.401862032907335 1854 5491415 A textile dye. SGTC_3141 9094609 49.47 µM 0.248280109900089 0.398434186405477 no 1305 0.401958843647241 1770 25236309 YDL196W YDL196W SGTC_1867 st057372 64 µM 0.247855533829892 0.398595295336507 no 1306 0.402123092689581 1919 688837 SGTC_2695 st077686 51.995 µM 0.247727146171648 0.398644016508769 no 1307 0.402172763401356 1824 2876092 SGTC_2 0422-0095 29 µM 0.247503236885996 0.398728990471578 no 1308 0.402259393370383 1882 6790840 SGTC_803 4488-1585 147 µM 0.247467594571182 0.398742517234976 no 1309 0.402273183740095 1962 747204 SGTC_2805 7950783 58.44 µM 0.246331190514824 0.399173862350829 no 1310 0.402712933562913 1884 1178958 YDL195W SEC31 SGTC_638 3970-0837 4.09 µM 0.246085047117575 0.399267307291596 no 1311 0.402808198948295 1831 4118451 YLR208W SEC13 SGTC_2159 5658611 73.75 µM 0.245835574610188 0.399362021972708 no 1312 0.402904758694207 1965 793844 SGTC_2775 cyproheptadine 69.59 µM 0.24570115802313 0.399413057002788 no 1313 0.402956787850388 2000 2913 A selective serotonin reuptake inhibitor. SGTC_1994 st072947 40.9 µM 0.245017958713809 0.399672479350843 no 1314 0.403221263034127 1899 5286565 YDL195W SEC31 SGTC_870 0573-2213 57.6 µM 0.244183486393472 0.399989402707557 no 1315 0.403544357988424 1929 3916321 SGTC_15 0266-0086 27.098 µM 0.243886668701856 0.400102146679455 no 1316 0.403659297157194 2004 1712902 YIL048W NEO1 SGTC_1884 5633444 25 µM 0.243511900740605 0.400244511369129 no 1317 0.403804433537623 1890 5724239 SGTC_2192 5915882 198.485 µM 0.24322961691777 0.400351752472302 no 1318 0.403913762334764 1889 2876149 SGTC_1673 st016611 27.3 µM 0.242105988187067 0.400778699312874 no 1319 0.404349019156303 1951 5226799 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.240871159194098 0.401248035795735 no 1320 0.404827487864721 1929 16623 A steroid. SGTC_3279 9140807 49.47 µM 0.240337147720397 0.401451048221781 no 1321 0.40503444953354 1972 45595718 SGTC_132 0417-1715 25.805 µM 0.240220167215354 0.401495523659563 no 1322 0.405079790086778 2024 6769098 SGTC_2935 9038016 29.96 µM 0.239455604815024 0.4017862380889 no 1323 0.405376158696443 2010 6463195 SGTC_2363 9053361 176 µM 0.237683490257556 0.402460269236563 no 1324 0.406063294814536 1978 6469797 YMR079W SEC14 SGTC_1020 4335-0961 93.3 µM 0.237100540397524 0.402682060148237 no 1325 0.406289396571103 1794 669075 SGTC_1196 1588-0294 184 µM 0.236525660072619 0.402900811576906 no 1326 0.406512399101867 1853 6144269 SGTC_3056 9094900 49.47 µM 0.23504729593996 0.40346349290882 no 1327 0.407086012237215 1802 25236784 SGTC_2580 diallyl disulphide 81.36 µM 0.233331303199261 0.404116868863911 no 1328 0.407752076453334 1866 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.231659969094995 0.404753497984245 no 1329 0.40840106281208 2031 5024745 SGTC_670 4204-0025 119 µM 0.230825904045352 0.405071296767134 no 1330 0.408725028039739 1959 719039 SGTC_2162 5663267 200 µM 0.230789327818041 0.405085234621303 no 1331 0.408739236305503 1991 6456493 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.228898209909963 0.405806033700554 no 1332 0.409474015960804 1953 91467 include heat shock SGTC_259 usnic acid 108.925 µM 0.227528585155821 0.406328265423803 no 1333 0.410006372150344 1974 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1946 st076057 65.1 µM 0.226503383385115 0.406719279352045 no 1334 0.410404964023209 1894 953009 SGTC_1262 0737-0114 49.6 µM 0.22446403143247 0.407497368297392 no 1335 0.411198125808241 2037 765919 SGTC_975 1335-0046 28.5 µM 0.223181743566161 0.407986796166545 no 1336 0.411697030069535 1821 16486740 SGTC_1552 6-methylflavone 10.6 µM 0.221678138512393 0.408560879993103 no 1337 0.412282224827085 2030 689013 SGTC_700 3453-2283 142 µM 0.221607001616451 0.408588045283029 no 1338 0.41230991575603 1970 565664 SGTC_2125 5246583 200 µM 0.21926729572761 0.409481760820391 no 1339 0.413220918121164 2071 835267 SGTC_3035 9091303 49.47 µM 0.218734679648618 0.409685274225489 no 1340 0.413428366307022 1945 25237002 SGTC_1957 st077035 62.4 µM 0.218229661131736 0.409878265039253 no 1341 0.413625087866049 2020 705593 SGTC_1431 4049-0260 9.09 µM 0.21774690523271 0.410062768695231 no 1342 0.41381315766268 1969 3854841 SGTC_3189 9110682 49.47 µM 0.217282675167208 0.410240210776132 no 1343 0.413994028898978 1889 17122418 SGTC_3350 9150499 3.57 µM 0.217019384382587 0.410340856255447 no 1344 0.41409661918453 1940 4910996 YPR165W RHO1 SGTC_2044 5102272 200 µM 0.215974066824654 0.410740497325279 no 1345 0.414503981096421 1930 592666 SGTC_1323 1348-1351 11.2 µM 0.215538478555927 0.410907056838233 no 1346 0.41467375770981 1881 6989654 SGTC_2238 6671620 73.2395 µM 0.215468135584644 0.410933955973218 no 1347 0.4147011763614 1976 729941 SGTC_236 1509-0011 5.31 µM 0.212965157300692 0.411891365934638 no 1348 0.415677069847454 1998 3107280 SGTC_1077 5-fluorocytosine 377 nM 0.212656528674437 0.41200945539979 no 1349 0.415797438114196 1939 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_358 0075-0058 9.45 µM 0.211555570156953 0.412430776052847 no 1350 0.416226887284988 2150 1069125 SGTC_1615 st002656 86.5 µM 0.211102049881573 0.412604360979417 no 1351 0.416403820350988 1967 1584458 SGTC_2404 5161160 200 µM 0.209663316350682 0.413155149342991 no 1352 0.416965229219444 1938 2831543 SGTC_3310 9130229 44.1445 µM 0.20887760242613 0.41345601536902 no 1353 0.417271894586074 2014 7761258 SGTC_3165 9101544 49.47 µM 0.208405142065615 0.413636954640822 no 1354 0.417456320843921 1999 5002184 SGTC_584 0986-0246 15.4 µM 0.208133382311189 0.413741039433315 no 1355 0.417562411273672 2052 53315 YDR232W HEM1 SGTC_2987 9018338 71.43 µM 0.206482744954275 0.414373368384953 no 1356 0.41820692093375 2033 5055682 SGTC_2295 7971645 200 µM 0.205619935951755 0.414703983169765 no 1357 0.41854390181892 1984 2978226 YKL099C UTP11 SGTC_2126 5251174 33.877 µM 0.203958947101047 0.415340617818313 no 1358 0.419192789992532 2068 790722 SGTC_1774 st048371 48.465 µM 0.202884923711438 0.415752394980628 no 1359 0.419612489178879 1874 4242727 SGTC_746 1095-0025 46.6 µM 0.202335362700224 0.415963130741647 no 1360 0.419827278107326 1990 6749286 SGTC_655 k060-0012 42 µM 0.201208054773625 0.416395486051044 no 1361 0.420267946746663 1934 5994525 SGTC_395 anisomycin 6.25 µM 0.200200553463894 0.416781977681325 no 1362 0.420661867167434 1935 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1981 st071826 47 µM 0.199895243249119 0.416899114861809 no 1363 0.420781255352031 1945 11838600 SGTC_1098 clofazimine 15.1 µM 0.199851397023274 0.416915937778544 no 1364 0.420798401532577 2022 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2755 lomerizine 42.69 µM 0.199109860850097 0.417200473343306 no 1365 0.421088403912132 1910 3949 A calcium channel blocker. SGTC_603 3794-0023 45.9 µM 0.198711811037029 0.417353227321477 no 1366 0.421244092200383 2055 3802260 SGTC_2791 5663188 71.43 µM 0.197014553566257 0.41800469967145 no 1367 0.421908074443533 2030 54690634 SGTC_213 1246-0773 967 nM 0.196961772753933 0.418024962583801 no 1368 0.42192872633724 1995 6251622 SGTC_2627 acetyl isogambogic acid 100 µM 0.196872813794273 0.418059115025064 no 1369 0.421963534377159 1895 6857789 A caspase activator and apoptosis inducer. SGTC_1280 0880-0253 10.1 µM 0.19673778247679 0.418110956393149 no 1370 0.422016370866408 1951 6836607 SGTC_2807 7945238 51.95 µM 0.194835129225552 0.418841575925099 no 1371 0.422761010056632 1967 17148797 SGTC_1812 st052057 4.327 µM 0.194302831571594 0.41904602865101 no 1372 0.422969384307129 1968 3645418 SGTC_880 0833-0487 87.2 µM 0.193149113279171 0.419489240750563 no 1373 0.423421094966385 1911 76075 SGTC_1488 4013-0813 75.9 µM 0.191681292677157 0.420053265908404 no 1374 0.423995930269943 1954 2910057 SGTC_2095 5432005 200 µM 0.19144473585284 0.420144180697444 no 1375 0.424088587012201 1968 783734 SGTC_1891 st059073 26.2 µM 0.19135129483439 0.420180093625714 no 1376 0.424125188002041 2100 688754 SGTC_1261 0712-0010 12.7 µM 0.190232814207791 0.420610019666638 no 1377 0.42456334928671 2063 2840123 SGTC_1937 st074714 47.2 µM 0.188881643785401 0.421129514220479 no 1378 0.425092790373718 1836 17250970 SGTC_1934 st074720 32.6 µM 0.187076764182824 0.421823663842722 no 1379 0.425800223010293 1957 17250992 SGTC_2432 5630864 12.22 µM 0.186982941579949 0.421859754309922 no 1380 0.425837003854776 1959 5714970 SGTC_1171 0368-0077 21.4 µM 0.186693357838291 0.421971151781393 no 1381 0.425950532108177 1947 3239779 SGTC_1353 1498-1206 8.11 µM 0.183920671875308 0.423038067242938 no 1382 0.427037843813762 1994 6756808 SGTC_637 1181-0519 7.26 µM 0.183611661912058 0.423157007822588 no 1383 0.427159056892817 2028 6252091 YGR060W ERG25 SGTC_1400 3771-8998 51.5 µM 0.182991451651297 0.423395753185578 no 1384 0.427402362980738 2031 670767 SGTC_3016 9080866 49.47 µM 0.181698284236698 0.423893638809087 no 1385 0.427909756270353 2014 17066299 SGTC_1864 st057645 30.4 µM 0.181145529896816 0.424106493257174 no 1386 0.428126674003437 2121 688666 SGTC_2191 5911152 200 µM 0.179590774974949 0.424705316265334 no 1387 0.428736923716954 2001 2875902 SGTC_3102 9121669 49.47 µM 0.179049711661505 0.424913750824078 no 1388 0.428949334038397 1983 41905072 SGTC_1820 st053765 18.6 µM 0.179024328545074 0.424923529712665 no 1389 0.428959299433332 1935 3690829 SGTC_3014 9081533 49.47 µM 0.17881950739245 0.425002439098486 no 1390 0.429039713740553 2102 21367265 SGTC_199 4063-0024 41.6 µM 0.178222558786187 0.425232436615758 no 1391 0.429274096990486 2077 306215 SGTC_2032 5185112 25.99 µM 0.178055999750143 0.425296614464663 no 1392 0.4293394984439 2063 5718189 SGTC_1174 0739-0097 51.1 µM 0.176339576539931 0.425958094672227 no 1393 0.430013585789553 1995 728447 SGTC_620 0109-0052 432 µM 0.176218377324186 0.426004810680024 no 1394 0.430061191843181 2092 493037 SGTC_1607 st000305 50.6 µM 0.175755417808984 0.42618326710099 no 1395 0.4302430478812 2086 5457690 SGTC_2210 7115885 190.385 µM 0.17558953732035 0.426247212524333 no 1396 0.430308211325215 1999 2927039 SGTC_783 0848-0141 92.7 µM 0.175524646343807 0.426272227934771 no 1397 0.43033370320338 2020 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2504 purpurogallin 52.29 µM 0.175155319243148 0.426414608830563 no 1398 0.430478795796162 1937 5281571 An antioxidant. SGTC_40 0327-0103 19.753 µM 0.174474169279638 0.426677227055982 no 1399 0.430746414666651 1970 409036 SGTC_863 0466-0191 129 µM 0.174447842583884 0.426687377999917 no 1400 0.430756758873285 2109 765160 YPR165W RHO1 SGTC_2545 solidagenone 89.61 µM 0.174076481376416 0.426830571165851 no 1401 0.430902678067567 2045 6708572 An anti ulcer agent SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.1738536336169 0.426916503663086 no 1402 0.430990246308847 2018 2724278 An inhibitor of dopamine biosynthesis. SGTC_1717 st033143 58.0435 µM 0.17358292356599 0.427020897041253 no 1403 0.431096626647096 2089 674616 SGTC_1632 st005650 90 µM 0.173342177697817 0.427113739685535 no 1404 0.431191236225678 1993 2759605 SGTC_921 1561-0023 372 µM 0.173022178883239 0.427237152148519 no 1405 0.431316997155284 2067 24050882 SGTC_971 1315-0384 26.7 µM 0.172592872485733 0.427402731945191 no 1406 0.431485727376652 1938 6769120 SGTC_578 3460-0051 92 µM 0.172451229713609 0.427457365155215 no 1407 0.431541399956092 2112 2876744 SGTC_3197 9113331 49.47 µM 0.172190154816026 0.427558068323509 no 1408 0.431644018800404 2068 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1050 3232-1156 69.3 µM 0.169979668588052 0.428410897093545 no 1409 0.432513063036549 1960 700529 SGTC_421 streptovitacin 30 mM 0.169961432522009 0.428417934155424 no 1410 0.432520233840366 1958 91467 include heat shock SGTC_1053 3366-3204 134 µM 0.169599694152392 0.428557529011619 no 1411 0.432662481547786 1948 3632071 YPR165W RHO1 SGTC_2729 fluphenazine 10.66 µM 0.169254249164598 0.428690844595158 no 1412 0.432798330295574 2074 3372 An atypical antipsychotic. SGTC_1376 2910-0861 41.3 µM 0.168638961421739 0.428928319174368 no 1413 0.43304031632787 2061 1112859 SGTC_2359 9039622 200 µM 0.16842224263925 0.429011969425911 no 1414 0.433125555471691 2044 6463596 SGTC_493 zm226600 134 µM 0.16791915335705 0.429206166749422 no 1415 0.433323440939608 2056 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2038 4100038 30.985 µM 0.167827336004405 0.429241610985097 no 1416 0.43335955824267 2020 3596803 SGTC_781 4335-2806 94.4 µM 0.1674471567962 0.429388377563083 no 1417 0.43350911157689 2110 845254 SGTC_2379 9035213 200 µM 0.165205121128541 0.430254103826271 no 1418 0.434391267287666 2152 646551 SGTC_511 blebbistatin 171 µM 0.165158096619871 0.430272265194589 no 1419 0.434409773156418 2091 3476986 A myosin inhibitor. SGTC_2254 7938975 95.19 µM 0.164637800289883 0.430473219040018 no 1420 0.43461453842745 2101 2969277 SGTC_1229 0139-0193 12.2 µM 0.163746013066077 0.430817695520544 no 1421 0.43496554660085 2141 3090752 SGTC_1523 st012844 44.7 µM 0.163235472698329 0.431014928998436 no 1422 0.435166518793632 2011 4274103 SGTC_1557 sumaresinolic acid 42.3 µM 0.162924671020988 0.431135007258098 no 1423 0.43528887284757 1993 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_765 1319-0117 244 µM 0.162797104972438 0.431184294257092 no 1424 0.435339093878914 2126 3487746 YGL099W LSG1 SGTC_659 k018-0002 107 µM 0.162768766531415 0.431195243371614 no 1425 0.435350250482223 2140 6797879 YHR007C ERG11 SGTC_332 4112-0506 40.9 µM 0.161039048503544 0.431863653778464 no 1426 0.43603132286694 2014 2790355 SGTC_2182 6325192 200 µM 0.160483002906048 0.432078566556017 no 1427 0.436250304903437 2149 736248 SGTC_3019 9081971 49.47 µM 0.159470305132744 0.432470027945498 no 1428 0.436649175989379 2119 16451803 SGTC_2634 4'-methoxyflavone 100 µM 0.159413779022059 0.432491880241737 no 1429 0.436671441820166 1983 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1317 1273-0028 910 nM 0.15927910996806 0.432543942466585 no 1430 0.436724489235271 2027 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1392 3455-1037 33.9 µM 0.15833689718636 0.43290822882264 no 1431 0.437095667546987 2091 981132 SGTC_2056 5235370 200 µM 0.157997476097057 0.433039472691537 no 1432 0.437229393759626 2002 5511916 SGTC_2393 9031399 185.94 µM 0.157820832799588 0.433107778234872 no 1433 0.437298991092488 2078 1526623 YDL150W RPC53 SGTC_2607 solasodine 47.35 µM 0.15623907732427 0.433719510241324 no 1434 0.437922287843537 1996 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_3119 9125183 49.47 µM 0.156207018708825 0.433731910315962 no 1435 0.43793492226064 2131 22695334 SGTC_726 3448-4391 34.2 µM 0.15547617012166 0.434014615708104 no 1436 0.438222969488121 2089 1356692 SGTC_3206 9114350 49.47 µM 0.153648820398811 0.434721614880568 no 1437 0.438943320425117 2153 17087243 SGTC_2124 5246320 200 µM 0.153640957330488 0.434724657543984 no 1438 0.438946420527052 2043 579342 SGTC_834 0312-0008 75.7 µM 0.151954568009948 0.435377305463059 no 1439 0.439611384457035 2102 6385573 YIL048W NEO1 SGTC_380 3970-0968 6 µM 0.151176744244036 0.435678389736493 no 1440 0.439918147420892 2044 2891601 SGTC_1179 1021-1431 9.29 µM 0.150657027413463 0.435879585357904 no 1441 0.440123136685344 2064 2840958 SGTC_1833 st055984 71 µM 0.15046412980071 0.435954265162176 no 1442 0.440199224396245 2007 676288 SGTC_2132 5317594 122.667 µM 0.148436605422076 0.436739353543401 no 1443 0.440999106545232 2059 794577 SGTC_2564 betulinic acid 100 µM 0.14827995479749 0.436800021467323 no 1444 0.441060917114939 2188 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_460 trequinsin 123 µM 0.145384336312938 0.437921707795473 no 1445 0.442203715539243 2167 5537 A vasodilator. SGTC_1244 0416-0015 52.5 µM 0.144896988665101 0.438110542740868 no 1446 0.442396102021166 2042 96201 SGTC_874 0599-0792 117 µM 0.144463472315555 0.438278531258873 no 1447 0.442567249354726 2172 765305 SGTC_3109 9122853 49.47 µM 0.143959022363406 0.438474020699193 no 1448 0.442766413960296 2088 1234709 SGTC_1686 st019653 115.5 µM 0.143671582477967 0.438585418967055 no 1449 0.442879906123408 2155 97252 SGTC_992 3909-8734 162 µM 0.143067108171754 0.438819700826478 no 1450 0.44311859077523 2028 4288319 SGTC_469 w7 172 µM 0.141496138008062 0.439428676735209 no 1451 0.443739005386296 2175 45115570 A P450 inhibitor. SGTC_1096 rimcazole 32.2 µM 0.141390484921998 0.439469637597379 no 1452 0.443780735345419 2027 18528119 A dopamine reuptake inhibitor. SGTC_1408 3909-7976 48.8 µM 0.140161424890249 0.439946181914597 no 1453 0.444266224731056 2077 24152374 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.139283321973809 0.440286702714856 no 1454 0.444613134275852 2065 390807 SGTC_495 decylubiquinone 155 µM 0.13863227192691 0.440539202883093 no 1455 0.444870370116252 2014 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_3263 9137018 49.47 µM 0.135944053842051 0.441582043583561 no 1456 0.445932754397014 1968 43844957 SGTC_111 0083-0039 52.457 µM 0.135347918364705 0.441813357607659 no 1457 0.446168400116314 2186 759313 SGTC_2957 9076800 11.52 µM 0.134806887001426 0.442023307171471 no 1458 0.446382280253697 2059 16459615 SGTC_1218 1348-1416 30.7 µM 0.132323194612777 0.442987322874324 no 1459 0.447364331018734 2109 6787668 SGTC_757 1066-0008 322 µM 0.132266955185139 0.443009155470424 no 1460 0.447386571821038 2137 6842497 SGTC_1342 1486-1464 234 µM 0.131746050184499 0.443211383177734 no 1461 0.447592580084528 2138 3253938 SGTC_1980 st071811 45.7 µM 0.130974321330357 0.443511013846412 no 1462 0.447897810501337 2142 4974850 SGTC_1743 st037606 46.3785 µM 0.129616910350553 0.444038119136398 no 1463 0.448434761795577 2094 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1415 3966-0071 78.1 µM 0.128327117738891 0.444539058837269 no 1464 0.448945052834093 2171 2893185 SGTC_3059 1327-0034 3 µM 0.127794764193754 0.444745844330814 no 1465 0.449155696828885 2070 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_363 0455-0021 3.06 µM 0.12662116036259 0.445201767817607 no 1466 0.449620124098769 2122 4597466 SGTC_555 4296-0685 37 µM 0.119906150700278 0.447811801458911 no 1467 0.452278746039186 2199 2908540 YHR072W ERG7 SGTC_2078 5212016 200 µM 0.11927489119855 0.448057281539316 no 1468 0.45252878769739 2232 1899708 SGTC_2368 9071271 200 µM 0.11693463955718 0.448967516192102 no 1469 0.453455924022789 2089 27209959 SGTC_623 k072-0108 16.9 µM 0.116645779938934 0.449079886096455 no 1470 0.453570379088516 2112 5382803 SGTC_2354 9060492 162 µM 0.116408092057778 0.449172352636314 no 1471 0.453664561230716 2168 6471895 SGTC_1827 berberine 7.24 µM 0.11597162581584 0.44934215612304 no 1472 0.453837514675248 1993 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_827 3253-0474 693 µM 0.115873822379828 0.449380206993149 no 1473 0.453876271316835 2192 5402065 SGTC_219 mitoxanthrone 164.414 µM 0.115059637667069 0.449696987280751 no 1474 0.454198925921858 2153 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1349 flufenamic acid 69 µM 0.114451590002084 0.44993358537238 no 1475 0.454439909864057 2166 3371 A non-steroidal anti-inflammatory. SGTC_719 2810-4230 27.3 µM 0.114196766980628 0.450032745133907 no 1476 0.454540907360206 2196 721079 SGTC_1065 prochlorperazine maleate 2.48 µM 0.113954667112406 0.450126956800939 no 1477 0.454636864837588 2200 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1265 0819-1001 68.8 µM 0.112835392977667 0.450562551863618 no 1478 0.455080528988372 2205 3106768 SGTC_150 3970-0969 77.2 µM 0.112417942113369 0.450725029158625 no 1479 0.455246014876582 2090 6615640 SGTC_1337 1486-1011 40.3 µM 0.112355744705945 0.450749237904404 no 1480 0.455270671840758 2220 X1337 SGTC_1236 0330-0013 258 µM 0.112352027174327 0.450750684864054 no 1481 0.455272145590022 2100 4617066 SGTC_2925 9010536 32.5 µM 0.11115857498168 0.451215241115627 no 1482 0.455745300184387 2117 2994177 SGTC_1855 st056195 39.6 µM 0.109673047579199 0.45179358215149 no 1483 0.456334338180822 2230 4028379 SGTC_3006 9075424 71.4286 µM 0.108864223970328 0.45210851401335 no 1484 0.456655091541101 2109 7465181 SGTC_1964 st076914 61 µM 0.108423395579699 0.452280172181527 no 1485 0.456829921770076 2224 24208661 SGTC_706 4262-0057 46.9 µM 0.1081259258063 0.452396011679277 no 1486 0.456947901446966 2194 883298 SGTC_2797 7859098 81.82 µM 0.106899766594521 0.452873540398826 no 1487 0.457434249180756 2151 972681 SGTC_832 4083-0019 164 µM 0.10675500137825 0.452929923844379 no 1488 0.457491673543592 2183 1990758 SGTC_1969 st069479 40.1 µM 0.106715769819109 0.452945203993876 no 1489 0.457507235772406 2204 3895485 SGTC_1489 4065-0444 182 µM 0.106074523761275 0.453194970322177 no 1490 0.457761612089784 2227 2877968 SGTC_3100 9120536 49.47 µM 0.104965877755759 0.453626833276429 no 1491 0.458201442356333 2256 16421196 SGTC_364 0083-0097 67.7 µM 0.104001815790824 0.454002419433394 no 1492 0.458583953796938 2124 5207356 SGTC_3133 9127736 49.47 µM 0.103387452043986 0.45424178913923 no 1493 0.45882773529808 2249 27243420 SGTC_3342 9147791 14.508 µM 0.103241474599737 0.454298667627575 no 1494 0.45888566189537 2213 1838168 SGTC_2972 9093619 59.92 µM 0.103134242798599 0.454340449903951 no 1495 0.458928214048508 2018 25236256 SGTC_448 monastrol 171 µM 0.10288821018375 0.454436317056077 no 1496 0.459025847474649 2194 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1617 st002906 78 µM 0.10250077111201 0.454587288925438 no 1497 0.459179600407755 2198 5150859 SGTC_417 st075190 100 µM 0.1018100581358 0.45485645261159 no 1498 0.459453720950238 2235 222757 SGTC_1360 1598-0022 39.8 µM 0.101576380377087 0.454947519110309 no 1499 0.459546464093892 2193 761525 SGTC_250 brefeldin a 552.239 µM 0.101305092386601 0.455053245652413 no 1500 0.459654136926789 2197 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1983 st071813 46.9 µM 0.10082808282495 0.455239153862821 no 1501 0.459843466783213 2104 11838595 SGTC_2709 st078560 56 µM 0.100357851993794 0.455422429747249 no 1502 0.460030115007065 2235 17250903 SGTC_1039 k821-0043 94 µM 0.0974977747893001 0.456537368562354 no 1503 0.461165550636993 2215 15992768 SGTC_2624 nerol 100 µM 0.0966998341498873 0.456848489785424 no 1504 0.461482385771948 2203 637566 A natural product oil. SGTC_2114 5491910 81.25 µM 0.0947034814585124 0.457626993592427 no 1505 0.462275176302751 2199 2849228 SGTC_2566 crystal violet carbinol 226 nM 0.0943768997601783 0.457754363946858 no 1506 0.462404882604932 1997 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_423 5-fluorouracil 457 µM 0.0932521561096239 0.458193059119223 no 1507 0.462851620140863 2161 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_315 k915-0449 187 µM 0.0931129838566359 0.458247345436239 no 1508 0.462906901312088 2151 20970215 YNL149C PGA2 SGTC_2294 7971431 200 µM 0.0925464267324441 0.458468347944005 no 1509 0.463131953132557 2205 5741572 SGTC_892 0929-0076 29 µM 0.0925343082755352 0.458473075250127 no 1510 0.463136767040718 2180 5751038 SGTC_2818 7996756 12.99 µM 0.0923898177424088 0.45852944022038 no 1511 0.463194164545983 2216 2241621 SGTC_1941 st076221 61.8 µM 0.0918556828948313 0.45873781054602 no 1512 0.463406351232739 2267 2828568 SGTC_2996 9066192 71.4286 µM 0.0902308702892722 0.459371732554231 no 1513 0.464051876715498 2142 6472854 SGTC_833 3852-0053 558 µM 0.0882831480356627 0.460131774048132 no 1514 0.464825816286499 2207 3123681 SGTC_1594 piperine 70.1 µM 0.087994646464494 0.460244365782049 no 1515 0.464940465570325 2224 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_903 1134-0042 114 µM 0.0876480113108715 0.460379649166886 no 1516 0.465078220738418 2136 701009 SGTC_2697 mebhydrolin 72.4 µM 0.0852795505177015 0.461304124514366 no 1517 0.466019574311523 2224 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_536 3852-0578 10.6 µM 0.08216107184773 0.462521670644104 no 1518 0.467259314455446 2240 2869208 SGTC_2712 st079126 47.7 µM 0.0821063163947486 0.462543051960366 no 1519 0.467281085164749 2247 3152970 SGTC_3117 9124945 49.47 µM 0.0818830320774499 0.462630242800068 no 1520 0.467369863782177 2158 17592065 SGTC_2326 6164455 177.58 µM 0.0810484757386193 0.462956146611777 no 1521 0.467701700606915 2187 2888790 SGTC_2776 terbinafine 19.92 µM 0.0809445612809862 0.462996728143332 no 1522 0.467743020716083 2260 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_397 arbidol 50 µM 0.0799877724681908 0.463370399249472 no 1523 0.468123490482909 2249 131410 A RNA synthesis inhibitor. SGTC_1266 0828-0227 32.9 µM 0.0793559889875417 0.463617158199572 no 1524 0.468374736947381 2203 3913820 SGTC_1873 rapamycin 2 nM 0.0788555555164062 0.463812625035063 no 1525 0.468573757333033 2212 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1602 st001878 87.6 µM 0.0777957838168468 0.46422659539262 no 1526 0.468995250156514 2221 595405 YLR310C CDC25 SGTC_1356 1502-0781 85.8 µM 0.0775138803592879 0.46433671968252 no 1527 0.469107374783127 2207 567702 SGTC_1001 4048-4355 44.4 µM 0.0771035676785099 0.464497011325239 no 1528 0.469270577427473 2246 21824233 SGTC_2387 9077560 195.08 µM 0.0768824023028751 0.464583413584674 no 1529 0.469358548517019 2226 5303272 SGTC_1427 4048-4900 550 nM 0.0753656065278844 0.465176022113411 no 1530 0.46996191168586 2271 24132586 SGTC_3116 9124943 49.47 µM 0.0752601832238814 0.465217213635439 no 1531 0.470003850391489 2204 41905195 YPL160W CDC60 SGTC_392 N-ethylmaleimide 8.33 µM 0.075093828489904 0.465282213349263 no 1532 0.470070029056787 2214 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1278 0874-0585 172 µM 0.0750828042592954 0.465286520874904 no 1533 0.470074414707333 2209 766306 SGTC_1124 fisetin 1.16336 µM 0.0737025431563636 0.465825865774324 no 1534 0.470623537574473 2122 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2332 7982454 138.89 µM 0.0729313312324963 0.466127248632775 no 1535 0.470930380802765 2264 2981748 SGTC_1682 st012968 530 nM 0.072709444819688 0.466213963503731 no 1536 0.471018666282989 2098 24207270 SGTC_2919 7978188 46.38 µM 0.0720027348044695 0.46649016173737 no 1537 0.47129986572163 2279 2980291 SGTC_2093 5331342 194.4 µM 0.0713073555967073 0.466761947388837 no 1538 0.471576570607269 2275 33839 SGTC_1448 4255-0083 152 µM 0.071263438439941 0.466779112722057 no 1539 0.471594046558514 2276 5399660 SGTC_2473 5854593 8.94 µM 0.0701847264563343 0.467200754295996 no 1540 0.472023315433687 2220 2872951 SGTC_2526 patulin 37.61 µM 0.0699898043887503 0.467276948404227 no 1541 0.472100887328248 2214 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2160 5660466 132.927 µM 0.0688386796362606 0.467726941946278 no 1542 0.472559014600433 2299 2859134 SGTC_3292 9120825 59.784 µM 0.068454293391171 0.467877214046819 no 1543 0.472712001636202 2298 24824900 SGTC_806 3966-4455 5.86 µM 0.0683208644425937 0.467929377880607 no 1544 0.472765107754901 2119 714982 SGTC_1067 clotrimazole 1.36 µM 0.0682382357845213 0.46796168169833 no 1545 0.472797995068826 2213 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2330 7979373 200 µM 0.0680001685065348 0.468054755693969 no 1546 0.47289275007384 2229 1863007 SGTC_160 3453-0671 289.699 µM 0.0675307686232721 0.468238275831075 no 1547 0.473079584053462 2259 5322268 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.0674492381785597 0.468270152280981 no 1548 0.473112036003063 2235 688761 SGTC_1871 st057448 67.3 µM 0.0666622303150203 0.468577863923655 no 1549 0.473425301619509 2270 691747 SGTC_3309 9129340 25.759 µM 0.0665964637893044 0.468603578783047 no 1550 0.473451480492546 2229 17158987 SGTC_1051 3253-3903 78 µM 0.0650283996126994 0.46921673395346 no 1551 0.474075694241263 2292 5509239 SGTC_343 4130-2827 29.8 µM 0.0646457690985033 0.469366363889596 no 1552 0.474228021213806 2201 1118244 SGTC_1282 0886-0010 32.4 µM 0.0645444950111231 0.469405968448207 no 1553 0.474268339526643 2285 2836211 YNL267W PIK1 SGTC_2232 chlorophetanol 41.5365 µM 0.0640712048272659 0.469591058781477 no 1554 0.474456764970365 2297 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1782 st039423 80.636 µM 0.063979097508969 0.469627080099765 no 1555 0.474493435237133 2137 2068169 SGTC_1807 st050092 58.9 µM 0.0638198443652064 0.469689361385197 no 1556 0.474556838474954 2234 5008496 SGTC_1033 k072-0102 21.3 µM 0.0608372370540731 0.47085594540302 no 1557 0.475744417175272 2301 5965931 SGTC_177 1327-0068 8.361 µM 0.0594150795397216 0.471412281042914 no 1558 0.476310751270994 2313 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1314 1222-0010 41.1 µM 0.0585118813656097 0.471765633342359 no 1559 0.476670449374468 2251 3526027 SGTC_723 4182-0001 115 µM 0.0580021763434505 0.471965051724295 no 1560 0.476873447487942 2214 744821 YLR208W SEC13 SGTC_1309 pyrazolanthrone 13.4 µM 0.0559005236723737 0.472787381731203 no 1561 0.477710526826878 2312 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1710 st031758 61.5 µM 0.0553062179293038 0.473019941557855 no 1562 0.477947254279538 2295 5394341 SGTC_412 gemfibrozil 100 µM 0.0550274364768724 0.473129035661624 no 1563 0.478058302877436 2313 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2107 5363541 170.161 µM 0.0547476710972412 0.473238516826737 no 1564 0.478169745121227 2317 244052 SGTC_3164 9100705 49.47 µM 0.0546145605173955 0.473290607975721 no 1565 0.478222769228483 2309 17174235 SGTC_2479 5617353 43.85 µM 0.0537937948739659 0.473611814330426 no 1566 0.478549726668146 2298 2731746 SGTC_3199 9111318 49.47 µM 0.0537898058598836 0.473613375471791 no 1567 0.478551315753801 2292 8548020 SGTC_1363 1636-0063 10.4 µM 0.0528439049747338 0.473983574823447 no 1568 0.47892813961895 2311 6072185 SGTC_1713 st033146 12.748 µM 0.0521416118685005 0.474258447403091 no 1569 0.479207928283462 2314 674619 SGTC_313 3474-0040 5.03 µM 0.0506705826053995 0.474834237468053 no 1570 0.479794009102899 2314 1043375 YIL048W NEO1 SGTC_624 k048-0052 28 µM 0.0490067643152446 0.475485552275545 no 1571 0.480456952637365 2245 6835531 SGTC_1128 3448-9350 235 µM 0.0489458294320008 0.475509406970906 no 1572 0.480481233000786 2178 619386 SGTC_2142 5622915 118.518 µM 0.0488972648507942 0.475528419022118 no 1573 0.480500584294799 2276 5322196 SGTC_1445 4239-0156 97.7 µM 0.0488216499533264 0.475558020835887 no 1574 0.480530714289085 2306 4008346 SGTC_1627 st003713 25.6 µM 0.0473609960195121 0.476129865726364 no 1575 0.481112757391854 2269 16195070 YER133W GLC7 SGTC_709 3807-1509 243 µM 0.0466945008778737 0.476390814467573 no 1576 0.481378356615344 2320 1886677 YPL242C IQG1 SGTC_1520 flindersine 88 µM 0.0466698056069766 0.476400483450234 no 1577 0.481388197874036 2316 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_3329 9141233 27.5565 µM 0.0460120051095362 0.476658038327486 no 1578 0.481650340675497 2305 4909101 YNL103W MET4 SGTC_771 0250-0039 27.3 µM 0.0454034321664488 0.476896327359185 no 1579 0.481892872668715 2257 3005115 SGTC_2001 4023502 57.655 µM 0.0451725970584552 0.476986713882248 no 1580 0.481984868162924 2299 108941 YCR052W RSC6 SGTC_3033 9090887 49.47 µM 0.0450944414548201 0.477017317005476 no 1581 0.482016015996888 2307 19325384 SGTC_1844 rapamycin 4 nM 0.0431118694695767 0.477793670797451 no 1582 0.482806178814418 2280 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_440 fluspirilene 35.1 µM 0.0421320727683413 0.478177379911754 no 1583 0.483196706245587 2294 3396 An atypical antipsychotic. SGTC_1590 st077108 57.8 µM 0.0420615067647368 0.478205015836654 no 1584 0.483224833074598 2318 5489485 SGTC_918 glabranin 770.725 nM 0.0417529756090644 0.478325847825705 no 1585 0.483347811161408 2284 124049 Also referred to as licorice root. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.0413953730645243 0.478465900442183 no 1586 0.48349035069848 2337 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3289 9119912 71.43 µM 0.0400592584738857 0.478989204068624 no 1587 0.484022941369479 2314 17014829 SGTC_2704 st078022 71.1 µM 0.0400152997907612 0.479006421579275 no 1588 0.484040464296654 2346 54697681 SGTC_626 0214-0009 33 µM 0.0399070900004933 0.479048804799569 no 1589 0.484083599302288 2310 3437874 SGTC_2444 5485484 36.41 µM 0.0398312682193648 0.479078502542466 no 1590 0.484113823785315 2309 6790631 SGTC_1129 3453-1384 223 µM 0.0390482670383067 0.479385193841599 no 1591 0.484425953201733 2281 1084452 SGTC_528 3492-0019 172 µM 0.038879854612354 0.479451160382442 no 1592 0.484493089056802 2335 2869262 SGTC_515 4092-1064 102 µM 0.0388164059670368 0.479476013134419 no 1593 0.484518382310845 2337 717353 SGTC_1197 1601-0112 267 µM 0.0373400162415648 0.480054335400449 no 1594 0.485106949689877 2344 7350313 SGTC_1905 st060207 84.5 µM 0.0372824850321556 0.480076872028365 no 1595 0.485129885351488 2289 1948547 SGTC_2247 cerulenin 830 nM 0.0362221958615377 0.480492229092123 no 1596 0.48555259393135 2331 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_210 3551-0445 56.827 µM 0.0360913868924847 0.480543473598538 no 1597 0.485604745059641 2303 2865180 YOR207C RET1 SGTC_304 1310-0298 97 µM 0.0359496798091828 0.48059898781175 no 1598 0.485661241343299 2331 1550234 SGTC_2411 st077133 39.94 µM 0.0348222060218984 0.481040692672088 no 1599 0.486110756761451 2330 1403142 YNL221C POP1 SGTC_868 0527-0199 213 µM 0.0332780146453237 0.481645690597796 no 1600 0.486726442909646 2226 2849450 SGTC_1465 k213-0056 144 µM 0.0324939727510436 0.481952886226709 no 1601 0.48703906127057 2287 24048857 YMR208W ERG12 SGTC_1402 3909-7673 35.9 µM 0.0323870763027723 0.48199477018203 no 1602 0.487081684349487 2346 5328014 SGTC_335 4077-0256 27.6 µM 0.0311689871588235 0.482472053387215 no 1603 0.487567386276951 2335 3121989 SGTC_1192 1488-0095 21.4 µM 0.030082020778088 0.482897980062962 no 1604 0.488000819791301 2298 915875 SGTC_759 3486-0358 89.3 µM 0.0282794579549726 0.483604355268636 no 1605 0.488719632112153 2365 875103 SGTC_688 0527-0193 473 µM 0.0282086263439474 0.483632113310417 no 1606 0.488747878567862 2324 4007154 SGTC_2280 7785178 200 µM 0.0277896625133575 0.483796301727724 no 1607 0.48891495544965 2343 2954328 SGTC_3132 9126706 49.47 µM 0.0274508337439894 0.4839290878964 no 1608 0.489050077020446 2316 850858 SGTC_1423 4048-0112 5.59 µM 0.025729106157008 0.484603855970812 no 1609 0.489736704090771 2363 X1423 SGTC_419 nsc-638432 893 µM 0.0253850270103179 0.484738710539464 no 1610 0.48987392698769 2317 368090 SGTC_1052 3253-3998 198 µM 0.0253628597382159 0.484747398594513 no 1611 0.489882767603357 2348 5450317 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.0245846317447772 0.485052415318779 no 1612 0.490193138843404 2350 5282309 SGTC_3076 9116187 49.47 µM 0.0245695632968037 0.485058321295303 no 1613 0.490199148469118 2343 27241210 SGTC_1221 2958-7315 257 µM 0.02427987176133 0.485171864573934 no 1614 0.490314684202955 2339 4562705 SGTC_1832 st054113 55 µM 0.0237051223431157 0.485397138541991 no 1615 0.490543910058092 2368 1251267 SGTC_2534 helenine 20.12 µM 0.0222149614998875 0.485981231033614 no 1616 0.491138241492504 2364 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1209 2323-2347 50.3 µM 0.0212107336999214 0.486374871300218 no 1617 0.491538775977569 2371 5412760 SGTC_21 0849-0113 22.993 µM 0.0205372659917437 0.486638866681034 no 1618 0.491807392188148 2357 1560156 SGTC_1434 4073-0095 163 µM 0.0203332058042236 0.48671885823559 no 1619 0.491888783428336 2370 24133745 SGTC_258 haloperidol 50.781 µM 0.0197176354927294 0.486960164904348 no 1620 0.492134311212874 2362 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3344 9148862 3.898 µM 0.0191502113588172 0.487182602259318 no 1621 0.492360637944497 2351 4905352 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.0185252588220197 0.487427596079206 no 1622 0.49260991369766 2363 6708739 YPR165W RHO1 SGTC_3311 9131146 2.8755 µM 0.0184659523023556 0.487450845662002 no 1623 0.492633569529326 2306 4900406 YPR165W RHO1 SGTC_2751 anetholtrithion 17.25 µM 0.0176047605702133 0.487788458309857 no 1624 0.492977079440218 2365 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_310 1273-0058 1.06 µM 0.0166519765128509 0.488161988046951 no 1625 0.493357129516592 2363 2734232 SGTC_983 1491-0821 12.2 µM 0.016415908261181 0.488254537930402 no 1626 0.49345129425118 2370 46495113 SGTC_3087 9117406 49.47 µM 0.0163142552010887 0.488294390917224 no 1627 0.493491842524666 2293 42546093 SGTC_1730 st033808 45.1 µM 0.0158616363899506 0.488471841110689 no 1628 0.493672387937718 2323 1045166 SGTC_2171 5739187 198.077 µM 0.0157847361672565 0.488501990238724 no 1629 0.493703062847587 2370 2262761 SGTC_1101 ebselen 5.29 µM 0.0154795477038338 0.488621641592426 no 1630 0.493824800553608 2388 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_3282 9108498 15.4605 µM 0.0150201230323673 0.488801764299491 no 1631 0.49400806316732 2359 16459645 SGTC_855 0428-0020 25 µM 0.0142906731471939 0.489087758163233 no 1632 0.494299040311685 2364 6812414 SGTC_2172 5754775 163.918 µM 0.0124862337655009 0.489795244667292 no 1633 0.495018842860377 2375 2263357 SGTC_2037 5169046 200 µM 0.0122955065372691 0.489870027116033 no 1634 0.495094926174728 2368 5718022 SGTC_356 1634-0012 32.5 µM 0.0121490621276176 0.489927446907541 no 1635 0.49515334467785 2384 735457 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.0113257471936547 0.490250266576978 no 1636 0.495481777181513 2376 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_316 k060-0003 58.6 µM 0.0105284173917221 0.490562903632542 no 1637 0.495799846753004 2379 6152314 SGTC_2043 5101342 149 µM 0.0104964467580356 0.490575439602193 no 1638 0.495812600485777 2371 678451 SGTC_70 0141-0289 43.283 µM 0.00956034519477379 0.490942497421133 no 1639 0.496186032186231 2335 352408 SGTC_2781 5567276 71.43 µM 0.00850555558362107 0.491356103570394 no 1640 0.496606815172468 2385 2853274 SGTC_2490 carminic acid 95.39 µM 0.00794626176920398 0.491575418745143 no 1641 0.496829933570453 2382 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1978 st071761 42 µM 0.00792422329468816 0.491584060716819 no 1642 0.496838725372927 2372 5147680 SGTC_2851 9015922 71.43 µM 0.00718563298681912 0.491873687220061 no 1643 0.497133371859054 2388 2996893 SGTC_2257 7960413 200 µM 0.00615268823302321 0.492278747313631 no 1644 0.49754544801214 2375 2974689 YIL048W NEO1 SGTC_2497 7-hydroxyflavone 100 µM 0.00592714073346057 0.492367194832106 no 1645 0.49763542680451 2385 5281894 SGTC_3088 9117578 49.47 µM 0.00552162558799918 0.492526216859057 no 1646 0.497797201289689 2398 678341 SGTC_3008 9078912 71.4286 µM 0.00423671134576011 0.493030101366712 no 1647 0.498309801770753 2397 16648731 SGTC_1122 capsaicin 818.572 nM 0.00344779356985182 0.493339484342196 no 1648 0.498624532095986 2393 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_50 0929-0078 56.389 µM 0.00304668971597581 0.493496783276056 no 1649 0.498784548537401 2385 1377751 SGTC_3226 9131256 49.47 µM 0.00293664662085878 0.493539938515505 no 1650 0.49882844918423 2399 17178073 SGTC_1597 7-benzyloxygramine 47.5 µM 0.00273615604213029 0.493618564441756 no 1651 0.49890843303103 2400 260807 SGTC_2820 7989630 71.43 µM 0.00180555072656475 0.493983520972084 no 1652 0.499279689867134 2404 2984098 SGTC_1954 st077032 68.9 µM 0.00179534378183917 0.493987523869522 no 1653 0.499283761842339 2392 698907 SGTC_2605 digitonin 300 nM 0.00168306423965772 0.494031557016646 no 1654 0.49932855483117 2400 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2394 5221648 200 µM 0.00108737508462782 0.49426517217772 no 1655 0.499566200189573 2400 788586 SGTC_2013 4024628 200 µM 0.000997644149996777 0.494300362694915 no 1656 0.499601997633793 2400 5230760 SGTC_2594 a-mangostin 100 µM -0.000216871965934248 0.494776673699985 no 1657 0.499913480604033 2409 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2596 sinensetin 100 µM -0.000280541554598868 0.494801643959374 no 1658 0.499888080113929 2408 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2197 6588183 93.1375 µM -0.000671068216675598 0.494954803111062 no 1659 0.499732282535428 2406 884136 SGTC_1633 st005664 67.9 µM -0.00252397569110572 0.495681497528008 no 1660 0.498993080451202 2409 2063822 SGTC_731 3966-0296 387 µM -0.00327529426592253 0.495976162447714 no 1661 0.498693348972762 2416 660956 SGTC_2338 7999974 200 µM -0.00515700324346663 0.49671417241616 no 1662 0.497942662485058 2424 315925 SGTC_2308 7584454 197.62 µM -0.00694903472011793 0.497417021183661 no 1663 0.497227758553685 2422 893577 SGTC_1790 st045711 43.5 µM -0.00719656363493908 0.497514104640399 no 1664 0.497129011274115 2417 585119 SGTC_794 k038-0031 316 µM -0.00786151968737712 0.497774908145611 no 1665 0.496863739713836 2416 6624242 SGTC_2108 5365811 200 µM -0.00936258897863066 0.498363648321729 no 1666 0.496264921970774 2434 780283 SGTC_1897 st060201 15 µM -0.00939231217056936 0.49837530620969 no 1667 0.496253064654159 2427 611878 SGTC_3127 9126946 49.47 µM -0.00942046419529651 0.498386347863252 no 1668 0.496241834118067 2439 27243249 SGTC_2127 5253358 187.912 µM -0.00948232099801866 0.498410609049247 no 1669 0.496217157926307 2431 20612 SGTC_2984 9022109 38.96 µM -0.00949038140866103 0.498413770466264 no 1670 0.49621394243239 2424 6459207 SGTC_2469 5655019 90.81 µM -0.0106564661899151 0.498871127800268 no 1671 0.495748765539217 2427 2788239 SGTC_1312 1218-2183 165 µM -0.0118956456675276 0.499357155670162 no 1672 0.495254435912084 2422 6744073 SGTC_1938 st074717 56.4 µM -0.0122096401067397 0.499480309962406 no 1673 0.495129179353088 2422 17250979 SGTC_2445 5742597 35.57 µM -0.0122873948960727 0.499510806803745 no 1674 0.495098162006921 2436 1774255 SGTC_1600 coumarin 106 71.1 µM -0.0124143095623041 0.499560585048199 no 1675 0.495047534242209 2517 100336 A hepatotoxic, DNA x-linker. SGTC_1271 0832-2808 169 µM -0.0126023108199964 0.499634322579152 no 1676 0.494972538458926 2430 3663794 SGTC_3284 9108171 64.8615 µM -0.0133718364922533 0.499936144722076 no 1677 0.494665568028516 2442 8687505 SGTC_3347 9188721 44.724 µM -0.013513952824409 0.499991885374391 no 1678 0.494608876937527 2450 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2823 7987624 58.44 µM -0.0135553309129273 0.499991885374391 no 1679 0.494592370980439 2439 2239440 SGTC_2262 9014885 67.46 µM -0.0136854047433838 0.4999408680138 no 1680 0.494540483843062 2462 6457424 SGTC_1201 1889-3372 45.9 µM -0.0142527190201311 0.499718356890454 no 1681 0.494314180275742 2449 5392199 SGTC_1044 1222-0021 1.78 µM -0.0145488886392702 0.499602193733462 no 1682 0.494196037943929 2492 4306703 SGTC_846 0335-0850 148 µM -0.0151266361857211 0.499375590654708 no 1683 0.493965575394077 2429 6819598 SGTC_2403 6032726 181.2 µM -0.0155363289964418 0.499214901812716 no 1684 0.493802150819005 2441 2881040 SGTC_413 propylparaben 100 µM -0.0158102117065283 0.499107480188688 no 1685 0.493692900845951 2435 7175 A pharmaceutical preservative. SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.0169100527737036 0.49867610387623 no 1686 0.493254186480382 2432 17037758 SGTC_2325 6158266 200 µM -0.0185227523216052 0.498043578713656 no 1687 0.492610913475105 2465 3623240 SGTC_3227 9130768 49.47 µM -0.019187628517771 0.49778280555115 no 1688 0.492345713400023 2447 17720899 SGTC_579 4491-1009 110 µM -0.0204994677193907 0.497268287899049 no 1689 0.491822468343225 2438 1271041 SGTC_2436 5633522 8.09 µM -0.0206504422454365 0.497209074317581 no 1690 0.491762250968801 2449 5724242 SGTC_1304 1165-0502 251 µM -0.0209347811085344 0.497097554198836 no 1691 0.491648840692868 2457 767425 SGTC_2271 7849410 118.62 µM -0.0236647188290421 0.4960268622366 no 1692 0.490560024207676 2439 972430 SGTC_2361 9034121 116 µM -0.0254017607954544 0.495345602179398 no 1693 0.489867253325306 2469 6496917 SGTC_3146 9095609 49.47 µM -0.0267014444966 0.494835880837912 no 1694 0.489348930501307 2477 17173999 SGTC_2407 paclitaxel 400 µM -0.0277210461237836 0.494436010397878 no 1695 0.488942318886699 2655 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2832 7992762 51.95 µM -0.028347898772074 0.494190172185942 no 1696 0.488692339118615 2469 2985177 SGTC_950 1165-0508 94.1 µM -0.0292126920361577 0.493851022390739 no 1697 0.488347479386677 2487 6148369 SGTC_1610 st001799 48.1 µM -0.0299877911158712 0.493547052129906 no 1698 0.488038395035559 2463 621897 SGTC_1834 st055981 52.8 µM -0.0309286610165606 0.493178076651558 no 1699 0.487663216333321 2497 471719 YDL150W RPC53 SGTC_3157 9099274 49.47 µM -0.031035082825448 0.493136342191098 no 1700 0.487620780545663 2462 17217662 SGTC_788 1182-0090 188 µM -0.0315498758320777 0.492934461628783 no 1701 0.487415508379766 2588 5715185 SGTC_1649 st011737 51.3 µM -0.0315895463142494 0.49291890457804 no 1702 0.487399690031761 2485 1761035 SGTC_1357 1503-1303 39.5 µM -0.0319811384918093 0.492765339610593 no 1703 0.487243546253034 2463 292895 SGTC_3305 9127027 53.8275 µM -0.0324703261331855 0.492573503568859 no 1704 0.487048489930866 2493 41905295 SGTC_2569 tetrandrine 100 µM -0.0326912103612678 0.492486883878652 no 1705 0.486960416630985 2493 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2167 5876490 200 µM -0.0336877661593225 0.492096089256613 no 1706 0.486563067313581 2576 686534 SGTC_1 0258-0098 57.368 µM -0.0353265991291972 0.491453445363654 no 1707 0.485909656763176 2436 6790032 YDR047W HEM12 SGTC_225 nsc-122657 1.016 µM -0.0357259696526843 0.491296841470601 no 1708 0.485750431489033 2548 275685 SGTC_2789 5281112 71.43 µM -0.035999822303252 0.491189457275682 no 1709 0.485641250322575 2495 765948 SGTC_1428 4049-0204 61.7 µM -0.0383484003154541 0.49026855051457 no 1710 0.48470495063636 2489 X1428 SGTC_1510 1123-0200 71.5 µM -0.0408478172032736 0.489288555039194 no 1711 0.483708609265611 2501 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_3131 9127911 49.47 µM -0.0415007221521271 0.489032568182947 no 1712 0.483448358578734 2568 45595681 SGTC_811 0416-0114 265 µM -0.0420468154020917 0.488818462849473 no 1713 0.483230688899856 2537 6612453 SGTC_800 3448-7362 155 µM -0.0425895785723831 0.488605666324211 no 1714 0.483014351524097 2473 15991913 SGTC_1797 st048695 56.8 µM -0.0431120345440552 0.48840083453217 no 1715 0.482806113020402 2476 592262 YIL048W NEO1 SGTC_3219 9131112 49.47 µM -0.043750892577479 0.488150370822646 no 1716 0.482551485807945 2485 17612988 YMR079W SEC14 SGTC_589 1227-0070 34.1 µM -0.0443537593422909 0.487914021741245 no 1717 0.482311210023279 2532 2841384 SGTC_732 3970-1727 52.7 µM -0.0463807706203633 0.487119379828786 no 1718 0.481503381419533 2502 1275699 SGTC_2999 9069765 71.4286 µM -0.0465949297481613 0.48703542673106 no 1719 0.481418036558978 2516 2097066 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.0468099532223466 0.486951135376595 no 1720 0.481332348103304 2559 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2451 5856223 45.7 µM -0.0475168560072302 0.486674026536854 no 1721 0.481050648179218 2511 2179896 SGTC_400 oxethazaine 37.5 µM -0.0477383408299275 0.486587204880163 no 1722 0.480962388679348 2533 4621 A local anesthetic. SGTC_761 k216-0224 480 µM -0.049135342658835 0.486039597465801 no 1723 0.480405719021408 2493 1340404 SGTC_2949 9072542 2.23 µM -0.0491757152421714 0.486023772299569 no 1724 0.480389632137787 2544 16457352 SGTC_2953 9074162 66.49 µM -0.0510017732932151 0.485308021032465 no 1725 0.479662053752692 2502 16451992 SGTC_171 k064-0041 9.68 µM -0.0511647027928058 0.485244160599385 no 1726 0.479597139039313 2500 53325 SGTC_2057 5236571 38.335 µM -0.0511799210806539 0.485238195790614 no 1727 0.479591075764716 2505 54684039 YBR257W POP4 SGTC_1676 st018489 23.4 µM -0.0543441676701082 0.483998042902499 no 1728 0.478330480405148 2558 3696235 SGTC_282 k297-0036 65.7 µM -0.0545646073772556 0.483911652312678 no 1729 0.478242667976662 2552 5061378 SGTC_2998 9066762 71.4286 µM -0.0547143823925926 0.483852955732329 no 1730 0.478183005517429 2534 4945196 SGTC_1783 st039459 87.517 µM -0.0547489560616704 0.483839406418367 no 1731 0.47816923326228 2618 729761 SGTC_1687 st020778 55.3625 µM -0.0548459689774379 0.483801387456472 no 1732 0.478130588772128 2516 4259299 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.0559837233898726 0.483355517275176 no 1733 0.4776773868386 2639 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2307 7538926 6.34 µM -0.0561760640227384 0.483280143689105 no 1734 0.477600774593808 2544 96582 SGTC_1424 4048-1941 275 µM -0.056881288599169 0.483003788571789 no 1735 0.477319879855965 2573 X1424 SGTC_758 0868-0029 16 µM -0.0574212975293248 0.482792181732975 no 1736 0.477104799007615 2508 762687 SGTC_3149 9097855 49.47 µM -0.058463396450563 0.482383840651233 no 1737 0.476689759001555 2567 25236625 YMR079W SEC14 SGTC_770 0389-1121 67.2 µM -0.0585959348647378 0.482331907473624 no 1738 0.476636974314704 2666 6753108 SGTC_66 0109-0187 42.4 µM -0.0598863063919395 0.48182631066377 no 1739 0.476123093117987 2497 759417 SGTC_1758 st042942 75.2445 µM -0.0622880847500467 0.480885317921355 no 1740 0.47516670852211 2504 669317 SGTC_1279 0874-0590 65.2 µM -0.063269826103176 0.480500711842179 no 1741 0.474775821444588 2579 3523074 SGTC_1417 3966-0327 90.4 µM -0.0642456911442563 0.480118425849283 no 1742 0.474387298121904 2535 651118 SGTC_307 1501-1223 22.3 µM -0.0642562074553334 0.480114306281839 no 1743 0.474383111371545 2549 2830329 SGTC_1539 benzyladenosine 56 µM -0.0652992948449402 0.479705707003275 no 1744 0.473967851890074 2522 92208 A nucleotide analog. SGTC_3154 9100113 49.47 µM -0.0654047320939641 0.47966440619383 no 1745 0.473925878241626 2529 25237525 SGTC_3207 9114163 49.47 µM -0.06543905837775 0.4796509602973 no 1746 0.473912213310128 2553 849233 SGTC_1172 0370-0043 85 µM -0.065769671557861 0.479521457498024 no 1747 0.47378060126438 2602 376585 SGTC_2017 5132927 60.65 µM -0.0662798465030544 0.479321623723787 no 1748 0.473577514049184 2554 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_345 1362-0200 395 µM -0.0684336249399825 0.478478053986514 no 1749 0.472720227864474 2554 1419823 SGTC_702 1488-0190 94 µM -0.0690024579126999 0.478255275289763 no 1750 0.472493831516693 2539 949357 SGTC_556 4058-0063 51.5 µM -0.0690321876885072 0.478243632056866 no 1751 0.472481999266539 2537 6615692 SGTC_2123 5259487 200 µM -0.0693435070529281 0.47812170948752 no 1752 0.472358097720808 2563 2173474 SGTC_2719 novobiocin 32.65 µM -0.0698465025914482 0.477924724760697 no 1753 0.472157916907578 2544 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.0702254824372626 0.477776311017176 no 1754 0.472007096169412 2538 803109 SGTC_1679 SEC14.276 6.7 µM -0.0717125177272667 0.477193997418476 no 1755 0.471415347053621 2602 1005053 YMR079W SEC14 SGTC_826 1683-5028 118 µM -0.0719028748452518 0.477119458266501 no 1756 0.471339601089125 2589 722377 SGTC_1066 ketoconazole 628 nM -0.0723652246084592 0.476938416842276 no 1757 0.47115562947673 2594 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2288 7946289 167.31 µM -0.0729064711245039 0.476726488015479 no 1758 0.4709402722188 2564 1246052 SGTC_2219 9098279 200 µM -0.0733612374688387 0.476548426186122 no 1759 0.470759331232417 2543 902349 SGTC_285 1486-1325 46 µM -0.0739513842827557 0.476317363695514 no 1760 0.470524534500473 2583 22310230 SGTC_3283 9109332 35.8195 µM -0.0745422777668724 0.476086016836326 no 1761 0.470289450963464 2511 17027281 SGTC_1368 1852-0141 284 µM -0.0748273920769607 0.475974391643063 no 1762 0.470176023591328 2601 2838987 SGTC_2848 9016370 25.97 µM -0.0754351468341134 0.475736455691032 no 1763 0.469934247866797 2536 7894410 SGTC_252 miconazole 1.30953 nM -0.0765705659205281 0.47529196243084 no 1764 0.469482587590017 2542 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_487 nimodipine 119 µM -0.0770981926420762 0.475085417833463 no 1765 0.469272715392696 2524 4497 L-type voltage-gated calcium channels inhibitor SGTC_2753 fluvastatin 17.09 µM -0.0773523485423077 0.474985928427308 no 1766 0.469171623750686 2611 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1258 0671-0043 57.1 µM -0.0782983807227177 0.474615617593582 no 1767 0.468795352753169 2592 4298767 SGTC_2384 9036245 200 µM -0.0800406619627387 0.473933684014408 no 1768 0.468102458062893 2619 6462766 SGTC_197 4544-0043 41.561 µM -0.0804607488374435 0.473769272229649 no 1769 0.467935406436277 2556 896523 SGTC_961 1252-1571 372 µM -0.0805679009630648 0.473727336208041 no 1770 0.46789279725523 2591 6813498 SGTC_937 3122-0005 46.7 µM -0.0810541575414434 0.473537034116414 no 1771 0.467699441328697 2548 759535 SGTC_909 3448-9333 149 µM -0.0815442352474024 0.47334524269318 no 1772 0.467504573673021 2549 3344074 SGTC_91 0417-1751 58.384 µM -0.0833462336407615 0.472640085879839 no 1773 0.466788119510799 2534 6795624 SGTC_1853 st056710 91.2 µM -0.084437018091788 0.472213282350305 no 1774 0.466354488090477 2714 269167 SGTC_1626 st003712 1.76 µM -0.0844402073198206 0.472212034511637 no 1775 0.466353220300234 2650 24207035 SGTC_616 4092-0450 108 µM -0.0845521778929632 0.472168224330051 no 1776 0.466308709682567 2609 787165 SGTC_1399 3562-5772 25 µM -0.0846702714760254 0.472122018793015 no 1777 0.466261765498475 2543 23847490 SGTC_3326 9140064 16.379 µM -0.0847194317072459 0.472102784370884 no 1778 0.466242223618651 2554 1868434 SGTC_2064 5220758 200 µM -0.0847806742968926 0.472078822698652 no 1779 0.466217878946137 2666 788518 SGTC_367 0335-0881 7.1 µM -0.0848220049728908 0.472062651785246 no 1780 0.466201449572345 2630 23828853 SGTC_255 tunicamycin 200.472 nM -0.0848964860377571 0.472033510668754 no 1781 0.466171842719458 2589 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_431 k089-0097 107 µM -0.0860826981580756 0.471569419091741 no 1782 0.46570033871713 2536 5499420 SGTC_817 1391-0715 46 µM -0.0860854234691766 0.471568352889948 no 1783 0.465699255496334 2619 1353946 SGTC_17 0960-0276 49.807 µM -0.086942432065313 0.471233082377331 no 1784 0.465358635643071 2555 6821114 SGTC_2282 7944268 200 µM -0.0880390557792616 0.470804101749873 no 1785 0.464922817309827 2627 2970414 SGTC_791 1348-1292 225 µM -0.0884586305729311 0.470639980128544 no 1786 0.464756081708402 2649 5437054 SGTC_2440 5628896 157.78 µM -0.0886184167681367 0.470577479186377 no 1787 0.464692585602966 2584 5522048 SGTC_102 gallobenzophenone 83.616 µM -0.0891448168274873 0.470371581054252 no 1788 0.46448341023586 2602 70837 SGTC_106 0092-0003 11.579 µM -0.0896762827663466 0.470163709470461 no 1789 0.464272231800206 2688 1072148 SGTC_3182 9108849 49.47 µM -0.0918813269072362 0.469301340893204 no 1790 0.463396163832709 2633 17133045 SGTC_2763 lisinopril 49.32 µM -0.0920239415273098 0.469245570793857 no 1791 0.463339508855063 2554 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1856 st057054 55.7 µM -0.0927889097037727 0.468946436816028 no 1792 0.463035630886249 2719 1266018 SGTC_1211 1056-0033 32.3 µM -0.0931113793099466 0.468820343197041 no 1793 0.462907538664721 2589 6741922 SGTC_3353 9151644 39.2805 µM -0.0969665090817575 0.46731313753206 no 1794 0.461376495481186 2657 4909158 SGTC_3200 9114385 49.47 µM -0.0979599106772305 0.46692483123503 no 1795 0.460982063425637 2661 17018030 YLR208W SEC13 SGTC_201 4262-0159 12.803 µM -0.0985527640325081 0.466693108418624 no 1796 0.460746688099205 2660 1341029 SGTC_2589 lobaric acid 100 µM -0.0990078070257635 0.466515257849714 no 1797 0.460566035726638 2634 73157 A novel microtubule depolymerizer. SGTC_5 0352-0601 109.883 µM -0.101525391665822 0.465531398197425 no 1798 0.459566701029617 2568 762456 SGTC_76 0433-0009 400.328 µM -0.101651327240601 0.465482188678513 no 1799 0.459516718585122 2744 2841569 SGTC_2975 9084847 53.72 µM -0.102068371563746 0.465319231742161 no 1800 0.459351202852439 2703 27211724 SGTC_2793 7325131 81.82 µM -0.102474081375214 0.465160709261494 no 1801 0.459190192299009 2657 4176441 SGTC_3052 9092717 49.47 µM -0.103841274633543 0.464626548425542 no 1802 0.458647655542388 2716 25237534 SGTC_79 0052-0007 94.094 µM -0.10439141011531 0.464411629055678 no 1803 0.458429369586754 2626 2801472 SGTC_54 0159-0055 9 µM -0.10562907836863 0.46392815188211 no 1804 0.457938326304346 2599 3319099 SGTC_1194 1488-0194 225 µM -0.106513266919628 0.463582789009459 no 1805 0.457587564904206 2578 1391452 SGTC_548 1436-0017 110 µM -0.107774427037791 0.463090229093982 no 1806 0.457087314488557 2642 9677137 SGTC_359 0081-0058 15.9 µM -0.108004099118429 0.463000534212346 no 1807 0.456996220303371 2856 3494159 SGTC_153 4077-0274 519.67 µM -0.108075379143189 0.462972697282546 no 1808 0.456967949168794 2619 3121976 SGTC_1127 asiatic acid 681.4 nM -0.108114708319981 0.462957338168897 no 1809 0.456952350495695 2610 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2950 9072895 21.46 µM -0.109242429000557 0.462516956141655 no 1810 0.456505104094168 2659 17332245 SGTC_2976 9009005 19.48 µM -0.110100576879444 0.462181874742569 no 1811 0.456164805328316 2635 2993148 SGTC_2481 5478948 45.16 µM -0.11132907143656 0.461702230675259 no 1812 0.455677701509843 2717 77792 SGTC_2871 9038510 12.99 µM -0.11139681407979 0.461675783367006 no 1813 0.455650843167326 2600 4945164 SGTC_2351 9026858 72.31 µM -0.111659254581583 0.461573325947905 no 1814 0.455546793681706 2604 1409300 SGTC_1947 st076332 61.6 µM -0.112153737320334 0.461380285602047 no 1815 0.455350754966007 2641 24208416 SGTC_381 3461-2219 42.7 µM -0.112571836166692 0.461217071742217 no 1816 0.455185007284548 2652 2883159 SGTC_1896 st058441 89 µM -0.11287639707399 0.461098183964885 no 1817 0.455064274562838 2635 688759 SGTC_499 genistein 192 µM -0.114293740044482 0.46054495874824 no 1818 0.45450247235166 2635 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_908 3448-7491 47.7 µM -0.114440221490219 0.46048778762858 no 1819 0.454444415639252 2617 1203031 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.114496511922715 0.460465817916154 no 1820 0.45442210564957 2604 16486 A toxic proline analog. SGTC_2450 5739737 12.93 µM -0.114839121439153 0.46033210272557 no 1821 0.454286319873146 2680 2262825 SGTC_2683 piperine 63.03 µM -0.115195524595193 0.460193008851503 no 1822 0.454145072959406 2618 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1647 st011722 22.4 µM -0.115853011445629 0.459936423488406 no 1823 0.453884518138161 2720 2854783 SGTC_1418 3966-3099 2.4 µM -0.115922342306638 0.459909367972375 no 1824 0.453857044233805 2625 740335 SGTC_1991 st073000 8.92 µM -0.116517300775875 0.459677200389943 no 1825 0.453621287724474 2807 4301969 YIL048W NEO1 SGTC_836 0330-0104 1.35 µM -0.117229472731973 0.459399311277439 no 1826 0.453339106036996 2624 46494820 SGTC_1800 st050079 29.0735 µM -0.11756773248904 0.4592673294426 no 1827 0.45320508666475 2665 3645560 SGTC_3253 9135987 49.47 µM -0.119118473535338 0.458662320624753 no 1828 0.452590747591041 2722 4182430 SGTC_740 k014-0057 261 µM -0.120516058223431 0.458117146481286 no 1829 0.452037179866875 2736 4012779 SGTC_558 k064-0027 21.3 µM -0.121092088080081 0.457892469848044 no 1830 0.451809047929351 2711 5088526 SGTC_141 0443-0274 32.331 µM -0.123348643822914 0.457012445473596 no 1831 0.450915511351875 2669 1627241 SGTC_1830 st055982 50.3 µM -0.124372861814427 0.45661308442902 no 1832 0.450510029812882 2614 455313 An antimicrobial agent. SGTC_2560 caryophyllene 100 µM -0.124401713549154 0.456601835250616 no 1833 0.450498608336361 2615 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2355 9061122 103.12 µM -0.124570837823445 0.456535895058031 no 1834 0.450431658284636 2740 5302957 SGTC_3250 9135583 49.47 µM -0.124657000964699 0.456502301203232 no 1835 0.450397550022627 2764 7699353 SGTC_2934 9036370 36.88 µM -0.124856771939642 0.456424414372051 no 1836 0.450318470741334 2719 6462800 SGTC_468 gf-109203x 121 µM -0.124888952536053 0.456411867937724 no 1837 0.450305732246148 2701 2396 A protein kinase C inhibitor. SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.125219136833594 0.456283139597985 no 1838 0.450175033741268 2702 551469 SGTC_2521 angolensin 13.4 µM -0.125367602164614 0.456225259189296 no 1839 0.450116267725686 2760 821428 A flavenoid. SGTC_1747 st037496 66.6 µM -0.127288930013051 0.45547629823623 no 1840 0.449355860803635 2639 723305 SGTC_2049 5262831 67.185 µM -0.127672572168492 0.455326767925655 no 1841 0.449204048331828 2675 763417 SGTC_1285 0929-0069 65.5 µM -0.127891126234262 0.455241586013742 no 1842 0.449117566808423 2667 1206237 SGTC_2967 9089538 49.85 µM -0.128915518886477 0.45484235428907 no 1843 0.448712248421545 2795 728216 SGTC_1764 st044502 93.5 µM -0.129182878601876 0.4547381649349 no 1844 0.448606471790506 2732 8407 SGTC_3345 9148410 3.559 µM -0.129358232334076 0.45466983175263 no 1845 0.448537097850835 2694 4903596 SGTC_484 loperamide 105 µM -0.130079448408821 0.454388796888301 no 1846 0.448251784875535 2610 3955 An opioid-receptor agonist. SGTC_2079 5212404 121 µM -0.130254664328775 0.454320524283641 no 1847 0.448182473518431 2666 758462 SGTC_2122 5258151 111.688 µM -0.130289396336439 0.45430699117228 no 1848 0.448168734528945 2672 2173356 SGTC_2670 beta-carotene 100 µM -0.131209496561709 0.453948499190269 no 1849 0.447804791868903 2649 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2002 4023503 131 µM -0.132373332453556 0.453495096022381 no 1850 0.447344503328384 2650 4736863 YCR052W RSC6 SGTC_1698 5-fluorocytosine 1.055 µM -0.132437645728646 0.453470042840551 no 1851 0.447319069962605 2655 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_151 3013-0144 2.285 µM -0.132456592544248 0.453462662159891 no 1852 0.447311577285015 2895 906558 YHR107C CDC12 SGTC_1966 st070145 16.1 µM -0.133641483482863 0.453001123145064 no 1853 0.446843039663514 2623 3748532 SGTC_1583 clindamycin 39.6 µM -0.133657365071365 0.452994937374509 no 1854 0.44683676016034 2643 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_3183 9108214 49.47 µM -0.133789647968428 0.452943414530372 no 1855 0.446784456661574 2639 4974831 SGTC_2052 5265182 7.135 µM -0.134428913691102 0.452694438207821 no 1856 0.446531709656153 2757 1239884 SGTC_1648 st011736 69.8 µM -0.135303629445897 0.452353790761703 no 1857 0.446185907792784 2769 2855514 SGTC_646 4092-0839 27.3 µM -0.135371588424587 0.452327326426294 no 1858 0.446159043242048 2750 877796 SGTC_883 0850-0245 24.6 µM -0.135509580306655 0.452273590787128 no 1859 0.4461044950675 2845 6823229 YPR165W RHO1 SGTC_2421 5690543 90.72 µM -0.136931664120518 0.451719865961816 no 1860 0.445542405109558 2735 3397993 SGTC_3047 9092122 49.47 µM -0.137376638076952 0.451546623173266 no 1861 0.445366548035888 2693 17173831 SGTC_2121 5257820 149.641 µM -0.137395426897532 0.451539308279036 no 1862 0.445359122788155 2734 791256 SGTC_3335 9143315 29.6265 µM -0.13832001723791 0.451179365638142 no 1863 0.444993753050686 2715 4899691 SGTC_1637 st007924 17.4 µM -0.138320782106348 0.451179067891748 no 1864 0.444993450817444 2634 683336 SGTC_2620 irigenin 100 µM -0.138346632684916 0.451169004848461 no 1865 0.444983236132943 2762 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2799 7812892 81.82 µM -0.138599637218011 0.451070517585942 no 1866 0.444883265000818 2757 20205235 SGTC_261 5-fluorouridine 15.376 µM -0.138699205337158 0.451031759455868 no 1867 0.444843923039792 2805 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_371 0195-0006 7.36 µM -0.14090285291965 0.450174082366695 no 1868 0.443973344165638 2623 3928593 SGTC_2015 5119600 184 µM -0.14098483320211 0.450142179455585 no 1869 0.44394096200597 2790 2828786 SGTC_3143 9086658 49.47 µM -0.141831306556007 0.449812790290797 no 1870 0.443606627489015 2747 25236626 SGTC_2388 9080168 200 µM -0.142252613794818 0.449648859385487 no 1871 0.443440237252606 2659 15943073 SGTC_1243 0416-0003 5.65 µM -0.142457918809465 0.449568978190339 no 1872 0.443359158113489 2730 2141977 SGTC_585 0kpi-0023 191 µM -0.142488700810468 0.449557001537554 no 1873 0.443347001877589 2764 64601 SGTC_43 0570-0105 72.5 µM -0.144518236862348 0.448767452097596 no 1874 0.442545628341174 2666 1114046 YDL195W SEC31 SGTC_2435 5706476 10.6 µM -0.146355790192875 0.448052764493951 no 1875 0.441820262873846 2746 5725375 SGTC_101 0490-5701 117.494 µM -0.146769850775456 0.447891745303353 no 1876 0.441656841263574 2645 4661669 SGTC_3210 9128157 49.47 µM -0.147674583891421 0.447539944106352 no 1877 0.441299795399789 2816 17590849 SGTC_1492 4158-0558 28.5 µM -0.14817220767088 0.447346463024025 no 1878 0.441103432373743 2780 3967268 SGTC_810 3825-7150 143 µM -0.148175425100224 0.447345212096164 no 1879 0.441102162818766 2739 22330411 YGL099W LSG1 SGTC_1306 1185-0270 9.02 µM -0.148261176192576 0.447311872495541 no 1880 0.441068326797297 2758 1548076 SGTC_67 0335-0847 266 µM -0.149067697377949 0.446998319296818 no 1881 0.440750107407981 3056 4552207 YOR254C SEC63 SGTC_235 0330-0087 5 mM -0.149482430892116 0.446837095227029 no 1882 0.440586485861642 2683 46494818 YHR062C RPP1 SGTC_2648 atorvastatin 78.68 µM -0.14970446104854 0.446750786531591 no 1883 0.440498894220061 2736 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_843 0310-0051 143 µM -0.151638906287261 0.445998926260692 no 1884 0.439735872725267 2686 2065037 SGTC_3039 9090270 49.47 µM -0.152049546161168 0.445839347867594 no 1885 0.439573928864517 2703 17173750 SGTC_1672 st016598 6.51 µM -0.152145578431092 0.445802030118119 no 1886 0.439536058119595 2740 4665860 YNL267W PIK1 SGTC_2800 7887935 81.82 µM -0.153300781407818 0.445353160660975 no 1887 0.439080542242462 2822 2961002 SGTC_2601 securinine 100 µM -0.155177813518479 0.444623964532941 no 1888 0.43834056932543 2714 442872 A GABA receptor antagonist. SGTC_2276 7947513 42.08 µM -0.157001249387211 0.443915769059703 no 1889 0.437621931722737 2777 2105100 SGTC_1809 st050081 57.6 µM -0.158730564727367 0.443244293995589 no 1890 0.436940578145083 2829 5036894 SGTC_3071 9117417 49.47 µM -0.159014500007189 0.443134060418058 no 1891 0.436828724917151 2782 45595590 YGL055W OLE1 SGTC_318 1488-0629 67.2 µM -0.159798083903779 0.442829868681078 no 1892 0.436520066754678 2769 3662576 SGTC_200 k038-0079 37.545 µM -0.160896309476222 0.442403587999457 no 1893 0.436087534523546 2728 3436683 SGTC_828 2074-0507 139 µM -0.162021356641482 0.44196696555176 no 1894 0.435644517952186 2821 X828 SGTC_663 1486-0733 13.9 µM -0.165821738793458 0.44049258980438 no 1895 0.434148618939686 2702 722445 YPR165W RHO1 SGTC_1160 4092-0570 10.5 µM -0.165837684637436 0.440486405263836 no 1896 0.434142344338357 2689 4994975 SGTC_254 nsc-64875 3.808 µM -0.167629609108481 0.439791506377347 no 1897 0.433437338046765 2849 56993 SGTC_1206 3978-0017 132 µM -0.169242727433697 0.439166106122707 no 1898 0.432802861436814 2991 3873677 SGTC_1641 st009299 47.1 µM -0.170739682662325 0.438585877666948 no 1899 0.432214229350175 2710 4046054 SGTC_2094 5332512 191.667 µM -0.172196109800043 0.43802148477648 no 1900 0.431641678065953 2849 755774 SGTC_1554 st069299 38.7 µM -0.172918648896235 0.437741534002822 no 1901 0.431357686383099 2792 24207999 SGTC_1521 st012942 49.4 µM -0.175998742324997 0.436548490230716 no 1902 0.430147465252058 2956 24207259 SGTC_1351 1496-0003 46.5 µM -0.176459839075488 0.436369938344893 no 1903 0.429966348661857 2826 3891978 SGTC_1741 st038134 10.228 µM -0.178134732604291 0.435721473612493 no 1904 0.429308582778828 2908 1272587 SGTC_718 1130-0073 349 µM -0.178433122360402 0.435605964809727 no 1905 0.429191419392832 2858 6740020 SGTC_609 0986-0026 86.3 µM -0.180217970479238 0.434915152413897 no 1906 0.428490725502728 2737 2848610 SGTC_1961 st076550 68.7 µM -0.182375651673207 0.434080303088272 no 1907 0.427643966253316 2857 1579337 SGTC_1995 st072814 61.1 µM -0.182540419272745 0.434016563293939 no 1908 0.427579318588009 2735 5769371 SGTC_537 1334-0398 209 µM -0.183141514625343 0.433784046126794 no 1909 0.427343491320157 2828 5846986 SGTC_2477 5967686 25.23 µM -0.184175625155472 0.43338408263333 no 1910 0.426937840340599 2722 776118 SGTC_308 4092-1169 104 µM -0.18572603359594 0.432784558241065 no 1911 0.426329805824289 2757 2268590 YDL196W YDL196W SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.185995947002903 0.432680201726869 no 1912 0.426223969847952 2833 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2004 4023728 41.89 µM -0.186581246154769 0.432453923885945 no 1913 0.425994485960548 2837 360084 YDR527W RBA50 SGTC_2954 9074818 52.69 µM -0.186729295351249 0.43239669127318 no 1914 0.42593644285126 2866 16648742 SGTC_1553 gossypol 38.6 µM -0.188283745153884 0.431795860504319 no 1915 0.425327113480975 2701 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_273 hydroxyurea 18.1 mM -0.190143682051794 0.431077159307722 no 1916 0.424598270547968 2737 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_172 1112-0046 2.638 µM -0.190233892217837 0.431042306835406 no 1917 0.424562926934675 2799 2802135 YIL048W NEO1 SGTC_2316 5844804 197.44 µM -0.190516137121668 0.430933265691337 no 1918 0.424452349583374 2860 776813 SGTC_1191 1487-1166 10.6 µM -0.191138851691539 0.430692707760187 no 1919 0.424208404740872 2867 3955771 SGTC_2334 9017922 200 µM -0.193021986420213 0.429965399675437 no 1920 0.423470874599595 2903 3163164 SGTC_1753 st043925 64 µM -0.193532112834349 0.429768418419434 no 1921 0.423271129507669 2837 670181 SGTC_989 1501-0895 10.3 µM -0.193637929862423 0.429727560203644 no 1922 0.423229698261338 2764 2830112 SGTC_2068 5226020 147 µM -0.194436511011583 0.429419235260017 no 1923 0.422917051870785 2788 1810509 SGTC_933 2914-0560 114 µM -0.194683727880457 0.42932379578543 no 1924 0.422820275718103 2954 463887 SGTC_293 4049-0273 38.5 µM -0.195024558444577 0.42919222298771 no 1925 0.422686860945304 2771 1380311 SGTC_3356 9151811 4.48 µM -0.196168904823562 0.428750521951111 no 1926 0.42223898276407 2739 1859254 YPR165W RHO1 SGTC_3138 9097216 49.47 µM -0.196438158228259 0.428646607004038 no 1927 0.422133616038802 2688 25237486 SGTC_2299 7976368 114.88 µM -0.197079034532291 0.428399288808965 no 1928 0.421882844845583 2898 2979718 SGTC_538 2922-0838 53.3 µM -0.197588187651925 0.428202823457238 no 1929 0.421683638744 2839 777039 SGTC_808 0711-0032 135 µM -0.198039440278671 0.428028714864008 no 1930 0.421507102953152 2717 4252555 SGTC_745 0469-0705 296 µM -0.198061092028696 0.428020361235296 no 1931 0.421498632908364 2918 3486736 SGTC_2249 haloperidol 116.36 µM -0.198127488357686 0.427994744556549 no 1932 0.421472659258395 2739 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1495 4469-0029 237 µM -0.199818526754648 0.427342419689597 no 1933 0.420811255635073 2740 793680 SGTC_3238 9133470 49.47 µM -0.2009069107853 0.426922676102102 no 1934 0.420385681933641 2905 3534688 SGTC_1031 k035-0009 16 µM -0.201659622662955 0.426632435400252 no 1935 0.420091415236465 2969 5180959 SGTC_2993 9054257 71.4286 µM -0.202693813937821 0.426233722925093 no 1936 0.419687179289484 2748 6470217 YGL055W OLE1 SGTC_916 4466-0038 42 nM -0.203637664737345 0.425869905260143 no 1937 0.419318328803575 2895 5722064 YGL116W CDC20 SGTC_301 4119-0100 24.5 µM -0.204693623805032 0.425462949023131 no 1938 0.418905751199581 2783 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1519 esterone 74 µM -0.205067648347246 0.425318822663087 no 1939 0.418759636074367 2758 698 A steroid. SGTC_3104 9120930 49.47 µM -0.205857622751501 0.425014447289677 no 1940 0.418451064279143 2847 17014836 SGTC_2860 9025725 38.96 µM -0.206472685490124 0.42477749592761 no 1941 0.418210849438337 2759 40546248 SGTC_16 erodoxin 22.806 µM -0.207628801618346 0.424332178737364 no 1942 0.417759406984414 2809 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_374 0880-0231 82.3 µM -0.208427706887464 0.42402450977267 no 1943 0.417447512187678 2846 6833587 SGTC_1560 lithocholic acid 53.1 µM -0.208750959035105 0.423900034250263 no 1944 0.417321328413539 2769 9903 A bile acid which acts as a detergent. SGTC_1498 4478-3555 97.6 µM -0.208967598942627 0.423816616421269 no 1945 0.417236766249874 2791 3437919 SGTC_3007 9078383 71.4286 µM -0.211999300218951 0.422649610796163 no 1946 0.416053790129894 2824 6496995 SGTC_2649 anisomycin 9.56 µM -0.2121708729874 0.422583586755063 no 1947 0.41598686470715 2828 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_842 0271-0008 11.1 µM -0.212749994466331 0.422360747295095 no 1948 0.415760984681301 2885 1221709 SGTC_2543 pimpinellin 60.67 µM -0.213035437684562 0.422250921078917 no 1949 0.415649660896738 2796 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1203 3992-3522 103 µM -0.215361997607069 0.421355987522568 no 1950 0.414742548164482 3148 5322312 SGTC_1091 telmisartan 47.6 µM -0.216125899338028 0.421062233743476 no 1951 0.414444806005261 2898 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_404 fumagillin 50 µM -0.216604389816895 0.420878255501454 no 1952 0.414258332189227 2831 12015870 A methionine aminopeptidase binder. SGTC_3128 9127691 49.47 µM -0.217657526656955 0.420473388270674 no 1953 0.413847979522584 2948 41316314 SGTC_641 4092-0595 30 µM -0.220832540017426 0.41925329899341 no 1954 0.412611412864766 2846 786260 SGTC_1666 st014829 29 µM -0.220968425893163 0.419201098211098 no 1955 0.412558508897118 2762 3858230 SGTC_2443 5493264 126.67 µM -0.221179461635808 0.419120031303813 no 1956 0.412476350246942 2973 5340055 SGTC_1921 5740136 50 µM -0.221668426053097 0.418932214553149 no 1957 0.412286005497943 2978 1774243 SGTC_3225 9130819 49.47 µM -0.22191072158004 0.418839152949785 no 1958 0.412191691999428 2918 4547121 SGTC_1441 4106-0040 13 µM -0.22216462828162 0.418741636564272 no 1959 0.412092864294211 2792 2904180 SGTC_3169 9102970 49.47 µM -0.222755096210116 0.418514878494549 no 1960 0.411863058959543 2794 17027839 SGTC_2519 cryptotanshinone 88.04 µM -0.223011656732398 0.418416359699243 no 1961 0.411763217097419 2933 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2616 abietic acid 100 µM -0.224593288871933 0.417809128951069 no 1962 0.411147843113501 2899 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1985 st071382 65.5 µM -0.225446551453237 0.417481619955317 no 1963 0.410815950392032 2812 6123237 SGTC_2511 berberine 10.47 µM -0.225669377896366 0.417396101579274 no 1964 0.410729288308933 2820 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_186 3455-3465 67.277 µM -0.225964238231638 0.417282943382062 no 1965 0.410614617366986 2793 755278 SGTC_2433 5607874 27.82 µM -0.226340012815039 0.41713874275077 no 1966 0.410468490014229 2800 2252428 SGTC_1739 st037196 92.5 µM -0.226705821638678 0.416998377109606 no 1967 0.410326249981389 2974 612214 SGTC_2698 st077697 67.5 µM -0.229057241652494 0.416096359743727 no 1968 0.409412213085632 2859 3154499 SGTC_1086 cerivastatin 2.18 µM -0.231057419267969 0.415329428362514 no 1969 0.408635097277398 2794 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_522 1273-0010 11.6 µM -0.231714149791825 0.41507768728202 no 1970 0.408380020259142 3048 5705015 SGTC_1945 st075991 56.6 µM -0.231977712510975 0.414976666959484 no 1971 0.408277662250243 2860 1084980 SGTC_674 0498-0004 451 µM -0.232564391494937 0.414751820371871 no 1972 0.408049840317526 2873 4231473 SGTC_2008 4012253 172 µM -0.233087130772156 0.414551502404175 no 1973 0.407846873934525 2803 603940 SGTC_2714 st079313 56.9 µM -0.234455675707562 0.414027170154907 no 1974 0.407315619949202 2828 2939799 SGTC_1877 wortmannin 25 µM -0.235470690229425 0.413638385335455 no 1975 0.406921712580755 2963 312145 A covalent inhibitor of PI 3-kinase. SGTC_1452 4194-0072 190 µM -0.236512474197183 0.413239434940458 no 1976 0.406517514406969 2990 1343545 SGTC_970 1315-0089 19.5 µM -0.238470946200124 0.41248968231851 no 1977 0.40575792349272 2833 6811083 YLR033W RSC58 SGTC_2098 5376439 882.5 nM -0.238502160604419 0.412477735232087 no 1978 0.405745819889282 2918 2844116 SGTC_2555 cholic acid 100 µM -0.239160291654427 0.41222585925078 no 1979 0.405490645970241 2990 6708657 Influences liver metabolism. SGTC_1308 1187-1617 41.4 µM -0.23929907925003 0.412172747903789 no 1980 0.405436839661666 2802 2882570 SGTC_2076 5212012 200 µM -0.23996507428941 0.411917906790304 no 1981 0.405178666144659 2781 604802 SGTC_1661 st013063 9.66 µM -0.240750053699641 0.41161758434243 no 1982 0.404874421219542 2846 721395 SGTC_1163 k060-0048 49.9 µM -0.242006472495601 0.41113700341241 no 1983 0.4043875739789 2837 6809982 SGTC_1885 st057546 99.9 µM -0.242725508616298 0.410862031610789 no 1984 0.404109022634272 2984 702008 SGTC_2861 9024595 19.48 µM -0.24316349026247 0.410694561338073 no 1985 0.403939374337732 2880 16482810 SGTC_410 α-linolenic acid 100 µM -0.243806667142425 0.410448660438765 no 1986 0.403690278246476 2953 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1359 1582-0056 520 nM -0.244051888621183 0.410354916049044 no 1987 0.403595316654463 2948 3661189 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.24464035929076 0.410129973690498 no 1988 0.403367455601752 2796 688667 SGTC_1087 pterostilbene 9.05 µM -0.244710584431355 0.410103132170075 no 1989 0.403340265994924 2970 5281727 Similar to reservatol, lowers cholesterol. SGTC_1569 carminic acid 40.6 µM -0.244948121198999 0.410012343762008 no 1990 0.403248300524859 2979 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1080 nisoldipine 24.4 µM -0.246154495230404 0.40955133273926 no 1991 0.402781319717702 2798 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2499 avocadenofuran 51.48 µM -0.247341204379949 0.409097958559679 no 1992 0.402322086355285 2823 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_377 3970-0964 33.1 µM -0.247514536621603 0.409031748314097 no 1993 0.40225502141454 2830 16481235 SGTC_1784 st039334 36.3 µM -0.247973297617351 0.408856521212546 no 1994 0.402077533538543 3080 3496984 SGTC_1377 2944-0135 198 µM -0.248615491094789 0.408611261342863 no 1995 0.401829112256584 2920 1894137 SGTC_2749 bexarotene 57.39 µM -0.24865450497541 0.408596362718497 no 1996 0.401814021698108 2945 82146 An retinoic acid receptor inhibitor. SGTC_136 0097-0015 404.482 µM -0.248775179042333 0.408550280530861 no 1997 0.401767345928438 2830 4861337 SGTC_2065 5221596 34.26 µM -0.249263443758559 0.408363838253667 no 1998 0.401578503329389 2972 788581 SGTC_2195 6536160 144.242 µM -0.249529661987433 0.40826219243248 no 1999 0.401475549716606 2833 3834386 SGTC_675 1309-0189 238 µM -0.24969716050039 0.408198242334451 no 2000 0.401410777127158 2890 4246530 SGTC_2641 levomentholum 100 µM -0.250088582296415 0.408048808978131 no 2001 0.401259422746646 2889 16666 SGTC_3293 9120939 62.045 µM -0.251341797830347 0.407570458116306 no 2002 0.400774931043498 3005 934087 SGTC_3334 9142812 21.919 µM -0.252561378197685 0.40710507802927 no 2003 0.400303589147385 2983 45283678 SGTC_2743 auranofin 4.32 µM -0.253959347631737 0.406571787715778 no 2004 0.399763482268748 2883 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2496 diffractaic acid 79.83 µM -0.254140898007069 0.406502543484776 no 2005 0.3996933541457 3109 94870 An apoptosis inducer which activates caspases. SGTC_256 clotrimazole 625 nM -0.255198770685002 0.406099123712965 no 2006 0.399284790247387 2912 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1709 st033179 39.1045 µM -0.255724259214674 0.405898765677241 no 2007 0.399081880857156 2860 573381 SGTC_263 alizarin 107.927 µM -0.257665192708428 0.40515894142702 no 2008 0.398332655700766 2873 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_3315 9136395 68.55 µM -0.257912720769715 0.405064615633711 no 2009 0.398237133580563 3004 16876844 SGTC_1390 3413-2614 145 µM -0.258274243729986 0.404926859588539 no 2010 0.398097631307932 2926 3421432 SGTC_768 0384-0033 77.3 µM -0.258842365958918 0.404710404003299 no 2011 0.397878434094379 2878 3965305 YMR134W ERG29 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.25899406022024 0.404652613147625 no 2012 0.397819911716914 2856 165521 SGTC_705 1124-0212 310 µM -0.25973214179212 0.404371456433604 no 2013 0.397535198850531 2991 9554485 SGTC_501 nsc-95397 161 µM -0.260189124370266 0.404197403234764 no 2014 0.397358946467692 3030 262093 SGTC_1009 4106-0057 9.87 µM -0.260870096075354 0.403938073388081 no 2015 0.397096343210319 2959 2928005 SGTC_1320 1313-0481 95.3 µM -0.261438829449594 0.403721518852543 no 2016 0.39687705818584 3027 6813365 YLR208W SEC13 SGTC_940 3232-1287 54.8 µM -0.261717732771172 0.40361533263068 no 2017 0.396769534079299 2865 1585493 YIL048W NEO1 SGTC_953 1188-0045 9.7 µM -0.262040905777514 0.40349230059893 no 2018 0.396644952734181 2985 6144426 SGTC_2184 6075246 200 µM -0.262518966375001 0.403310320344594 no 2019 0.396460682457851 2923 2267320 SGTC_1355 1499-0035 1.68 µM -0.263035485138007 0.403113723998652 no 2020 0.396261614326173 2864 1548538 SGTC_176 1486-1328 72.834 µM -0.263342063312987 0.402997046400038 no 2021 0.396143470815506 2938 22310231 SGTC_1389 3405-0187 19 µM -0.263480123948576 0.402944506068627 no 2022 0.396090270637575 2920 799890 SGTC_701 4424-0219 185 µM -0.263551561383255 0.402917320538857 no 2023 0.396062743751731 3045 2911779 SGTC_1425 4048-4433 7.33 µM -0.265093960451469 0.402330474938299 no 2024 0.395468539907043 2926 23734946 SGTC_481 bay k-8644 50 µM -0.267125053588208 0.401558028920986 no 2025 0.394686439140026 2881 2303 A calcium channel antagonist. SGTC_563 tetrahydrosecaminediol 614 µM -0.269149847904859 0.400788361087954 no 2026 0.393907186065321 3040 334274 A psychoactive constituent of the cannabis plant. SGTC_1224 0823-0416 294 µM -0.269947133689748 0.400485401099475 no 2027 0.393600462642681 3012 3598164 SGTC_896 0964-0007 44.5 µM -0.270437850193706 0.400298963875213 no 2028 0.39341171214173 2951 6756758 SGTC_2886 9058944 51.95 µM -0.271004237008963 0.400083805580767 no 2029 0.393193886752144 2918 4949929 SGTC_2111 5486399 200 µM -0.271274836535021 0.399981021282354 no 2030 0.393089829306973 2886 689674 SGTC_107 0358-0022 2.6945 µM -0.272573277333509 0.399487919121126 no 2031 0.392590627971038 2963 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1623 st003709 20.3 µM -0.273016638389194 0.399319582852138 no 2032 0.392420212845234 2879 16192618 SGTC_582 0987-0078 156 µM -0.273347743073165 0.399193880528478 no 2033 0.392292959263908 2947 1625765 SGTC_432 NS 1619 61.3 µM -0.273783311780678 0.39902853485369 no 2034 0.392125574529532 3056 4552 A K+/calcium channel activator. SGTC_1654 st012436 41.8 µM -0.273789731436613 0.399026098031784 no 2035 0.39212310766861 2940 4323132 SGTC_1714 st033236 13.627 µM -0.273879202039117 0.398992136508529 no 2036 0.392088727533956 3064 2916566 SGTC_2676 harmalol 100 µM -0.274076735957739 0.398917158691235 no 2037 0.392012825778627 2993 5459187 A monoamine oxidase inhibitor SGTC_45 0kpi-0036 14.9 µM -0.274319750048594 0.39882492311237 no 2038 0.391919454054954 3021 2795021 SGTC_862 0452-0056 10.2 µM -0.27504191734023 0.398550859123815 no 2039 0.391642017164808 2954 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2082 5219693 150 µM -0.276368729084209 0.398047461782399 no 2040 0.391132436151881 2884 2834649 SGTC_142 0335-0849 62.6745 µM -0.278479309444995 0.397247049598903 no 2041 0.390322222894771 2941 3889043 YPR107C YTH1 SGTC_178 4092-0806 87.505 µM -0.279715815482234 0.396778320287869 no 2042 0.389847771749249 2976 2169044 SGTC_3045 9092950 49.47 µM -0.280906976963778 0.396326920979382 no 2043 0.389390874596034 3035 44120432 SGTC_1656 st012921 11 µM -0.281077533199042 0.396262298810905 no 2044 0.38932546635829 3014 6732821 SGTC_1084 voriconazole 435 nM -0.283799860411586 0.39523122134632 no 2045 0.388281880752596 3023 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2849 9019321 12.99 µM -0.284058931131897 0.39513313677782 no 2046 0.388182609642895 3032 16489627 SGTC_1469 k284-2957 126 µM -0.284356779792364 0.395020379033066 no 2047 0.388068488571164 2951 23884841 SGTC_185 k048-0037 25.491 µM -0.286097021087112 0.394361745031301 no 2048 0.387401906535544 3056 6827589 SGTC_2847 9005661 71.43 µM -0.287317007261503 0.393900193343219 no 2049 0.386934800747402 2988 2991449 SGTC_1394 3474-0001 65.7 µM -0.287543156755558 0.393814651608499 no 2050 0.386848231062317 2947 5017666 YIL048W NEO1 SGTC_456 gingerol 170 µM -0.287974077906002 0.393651668556912 no 2051 0.386683290682108 3092 442793 A herb. SGTC_2971 9092186 9.93 µM -0.28808020178835 0.393611533226651 no 2052 0.386642673598248 2861 25236400 SGTC_812 4251-0442 148 µM -0.288444010642325 0.393473951774846 no 2053 0.386503441467714 3047 5723007 SGTC_65 0798-0905 34.986 µM -0.288664175906218 0.393390698421764 no 2054 0.386419189814107 3314 3602145 SGTC_2215 7188065 200 µM -0.289344439929611 0.393133494011033 no 2055 0.386158903899955 3030 940217 SGTC_1433 4060-0023 7.6 µM -0.28945701311314 0.393090935150621 no 2056 0.386115835540572 3035 3840627 SGTC_1043 0916-0009 19.3 µM -0.289880420962736 0.392930875119911 no 2057 0.385953860318219 3114 3101130 SGTC_1440 4100-1550 40 µM -0.289912286532155 0.392918829773908 no 2058 0.385941670907303 2942 742806 SGTC_1142 3253-1408 9.78 µM -0.290173331474268 0.3928201573304 no 2059 0.385841818653333 2995 256655 SGTC_2906 7926292 26.41 µM -0.290404811314663 0.392732665968325 no 2060 0.385753281667876 3044 2966319 SGTC_2677 mitomycin C 100 µM -0.292233078628993 0.392041835033776 no 2061 0.385054210920042 2945 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2888 9058547 12.99 µM -0.292890796673097 0.391793392117674 no 2062 0.384802811863905 2922 16476514 SGTC_2928 9011484 9.79 µM -0.294411278291709 0.391219222523099 no 2063 0.384221824893254 3046 2994751 SGTC_2415 st077333 57.7 µM -0.294693103144263 0.391112824831269 no 2064 0.384114166116065 3164 2766255 SGTC_2290 7904846 200 µM -0.295296504016813 0.390885049549083 no 2065 0.383883693452616 2990 2962154 SGTC_932 2857-0803 154 µM -0.296286793414233 0.390511310481694 no 2066 0.383505535375805 3155 674898 SGTC_2844 9010103 25.97 µM -0.297199051680363 0.390167110156826 no 2067 0.383157272915892 3099 2480525 SGTC_383 2324-0395 7.37 µM -0.297275210244304 0.390138378979461 no 2068 0.383128202993495 3056 3146421 SGTC_1749 st037932 54.2 µM -0.297676655435604 0.389986941810191 no 2069 0.382974981198895 3062 594497 SGTC_1825 st052143 62.6 µM -0.298145836493531 0.389809973800583 no 2070 0.382795929488651 3101 674173 SGTC_262 fenpropimorph 62.5 µM -0.298404996751983 0.389712232255006 no 2071 0.382697037920269 2909 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1761 st044296 37 µM -0.298781323702147 0.389570314047555 no 2072 0.382553450961286 2915 1826700 SGTC_2804 7954240 19.48 µM -0.29882477496967 0.389553928908805 no 2073 0.382536873237411 3088 828705 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.298997603206411 0.389488758653846 no 2074 0.382470937158837 3088 5282362 SGTC_969 1313-0238 134 µM -0.299125953015423 0.389440362382468 no 2075 0.382421972347121 2937 5212874 SGTC_1791 st048313 56.1 µM -0.29970292684864 0.389222826705559 no 2076 0.382201882938522 3051 1204976 SGTC_2769 toremifene 3.73 µM -0.300430917368492 0.388948402948827 no 2077 0.381924241804835 3133 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_566 0958-0068 16.5 µM -0.301573407861191 0.388517840758873 no 2078 0.381488641074519 3107 6815365 SGTC_2899 9053889 58.44 µM -0.301578584948798 0.38851589001831 no 2079 0.381486667532148 3044 6470052 SGTC_721 1187-1332 279 µM -0.302905438026695 0.388016021040562 no 2080 0.380980963493602 2866 25730 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.304012262320774 0.387599185964488 no 2081 0.380559274533424 2973 368090 SGTC_1116 jasmonic acid  1.58368 µM -0.304922939876308 0.387256317745951 no 2082 0.380212421878439 3097 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.305577560117097 0.387009908884346 no 2083 0.379963154064742 2976 1241132 A phosphatase inhibitor. SGTC_3300 9124615 50.48 µM -0.305900342456108 0.386888425531997 no 2084 0.37984026260401 3119 24824903 SGTC_24 0417-1663 219 µM -0.307045537718116 0.386457505799366 no 2085 0.379404355558724 3035 4329390 SGTC_2036 5160441 105 µM -0.308554158065676 0.385890048422286 no 2086 0.378830348414395 3010 134534 YIL048W NEO1 SGTC_1635 st007035 42.4 µM -0.310452485838694 0.385176352142531 no 2087 0.378108443208836 3005 3716403 SGTC_2382 9035899 200 µM -0.311212779398723 0.384890620679159 no 2088 0.377819434273953 2972 6462679 SGTC_2947 9072639 7.68 µM -0.311865697194677 0.384645292761144 no 2089 0.377571296449176 3029 16488146 SGTC_2455 5377712 9.75 µM -0.312155397771481 0.384536455193557 no 2090 0.377461213510618 3026 2243908 SGTC_2085 5307070 144.047 µM -0.312265387618432 0.384495135506999 no 2091 0.377419421221035 2925 2840351 SGTC_2630 antimycin a 100 µM -0.313005950168674 0.38421696389947 no 2092 0.377138070779319 2899 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1720 st037298 9.481 µM -0.313972908939368 0.38385384265607 no 2093 0.376770807314354 3040 597396 SGTC_2909 7941780 10.49 µM -0.317403550878283 0.382566361018388 no 2094 0.375468706600615 3117 1243215 SGTC_1126 isoteolin 1.0172 µM -0.317457223211436 0.382546228657565 no 2095 0.375448346480345 2959 133323 SGTC_1336 1486-0901 104 µM -0.317791288323237 0.382420928790014 no 2096 0.375321629664765 3020 5006114 SGTC_2664 lyso-paf C-16 73.48 µM -0.319358198559478 0.381833382551387 no 2097 0.374727452579553 2963 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_583 1488-1091 88.9 µM -0.323631273829303 0.380232488717308 no 2098 0.373108604031601 3060 4303273 SGTC_3068 9116768 49.47 µM -0.324335055168928 0.37996901516471 no 2099 0.372842191330677 3081 41904888 SGTC_2995 9067767 71.4286 µM -0.324640880566813 0.379854541128351 no 2100 0.372726441690236 3039 11673567 SGTC_1035 k081-0041 55.2 µM -0.324773028072921 0.379805080022177 no 2101 0.372676429692456 3133 731709 SGTC_3341 9147222 25.867 µM -0.325044743070806 0.379703386783709 no 2102 0.372573604304492 3096 1939759 SGTC_3099 9120367 49.47 µM -0.325152317070333 0.379663127968659 no 2103 0.372532897473432 2962 24824940 SGTC_2687 chenodiol 100 µM -0.327217726138405 0.378890416538112 no 2104 0.371751607351741 3082 5702181 A cholesterol synthesis inhibitor. SGTC_1754 st042065 16.137 µM -0.327264588891165 0.378872889833185 no 2105 0.371733886513394 3045 1126236 YIL048W NEO1 SGTC_972 1319-0219 195 µM -0.328334780939737 0.378472705055691 no 2106 0.371329274545655 3060 23903702 SGTC_2046 4110841 106 µM -0.328682020864451 0.378342887055738 no 2107 0.371198022623771 3147 44119630 YMR134W ERG29 SGTC_2816 7982706 58.44 µM -0.328724033218965 0.37832718138304 no 2108 0.371182143546355 3082 2981853 SGTC_2584 androsterone 48.74 µM -0.329281532974673 0.378118787714141 no 2109 0.370971450544864 3108 2754130 A steroid. SGTC_2270 7924575 90.91 µM -0.329979836014498 0.377857811735139 no 2110 0.370707599052056 3136 1262135 SGTC_813 k007-0158 173 µM -0.331164634008332 0.37741514613111 no 2111 0.370260066184032 3040 6523916 SGTC_2314 7727897 200 µM -0.331174093222559 0.377411612615559 no 2112 0.370256493867727 2975 900724 SGTC_306 1672-3436 11.6 µM -0.33222799524299 0.377017988938808 no 2113 0.369858553008526 3088 6797378 SGTC_1268 0828-0275 2.46 µM -0.334638994077017 0.3761179819378 no 2114 0.368948713064447 3096 745337 SGTC_2324 6149169 200 µM -0.336250022714903 0.375516972492192 no 2115 0.368341166986264 3056 2888231 SGTC_2682 pyrogallin 40.03 µM -0.338197543898764 0.374790834585178 no 2116 0.367607163306527 3040 822798 An ATP competetive kinase inhibitor. SGTC_1223 0764-0573 147 µM -0.338216876623119 0.374783628552813 no 2117 0.367599879390519 2991 1609797 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.34041422906856 0.373964878236842 no 2118 0.36677230231352 3017 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2141 5621638 7.665 µM -0.340505865537864 0.373930746106819 no 2119 0.366737803177752 3132 2856238 SGTC_3040 9091894 49.47 µM -0.341173554113248 0.373682079854983 no 2120 0.366486465476846 2989 25236966 SGTC_898 1000-0849 28.3 µM -0.344106824632631 0.37259027044204 no 2121 0.365382975328056 3102 6751807 SGTC_122 0236-0016 402.397 µM -0.344242939408256 0.372539631151977 no 2122 0.365331796201747 3059 6808838 SGTC_179 1273-0063 6.77 µM -0.344378568961548 0.372489174572483 no 2123 0.365280801904142 2997 3108139 SGTC_2419 paclitaxel 166.5 µM -0.344584823816778 0.372412448333035 no 2124 0.365203258315597 2918 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1037 k284-1091 78.7 µM -0.344879397610203 0.372302876472219 no 2125 0.365092519890115 2977 3334711 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.348667231038954 0.370894849684707 no 2126 0.36366957402435 3023 6708630 An antioxidant. SGTC_2798 7813637 45.45 µM -0.349199464544822 0.370697143918028 no 2127 0.363469784081337 3139 956368 SGTC_2306 7482397 179.52 µM -0.349530713096632 0.370574114125603 no 2128 0.363345458661002 3188 891448 SGTC_547 1120-0019 610 nM -0.349999686894064 0.370399954115717 no 2129 0.363169466314367 2992 3676939 SGTC_587 k089-0003 57 µM -0.350184157443945 0.370331455661544 no 2130 0.363100247748601 3057 9659696 SGTC_1354 1498-1681 81 µM -0.350394582378627 0.370253324725792 no 2131 0.363021295823158 3113 5754243 SGTC_2837 9008476 45.46 µM -0.351981932096438 0.369664113290654 no 2132 0.36242590630776 3194 2992805 SGTC_1015 4130-4525 82 µM -0.35215967749399 0.369598154650248 no 2133 0.362359257529526 3037 1363237 SGTC_841 0251-0215 91.2 µM -0.353131262967236 0.369237681771933 no 2134 0.361995018158519 3083 3888614 SGTC_74 000s-0487 160.283 µM -0.353412798164122 0.369133249429865 no 2135 0.361889496273407 3056 677548 SGTC_2226 7298446 200 µM -0.353762921172622 0.369003388679214 no 2136 0.361758281716726 3124 3283010 SGTC_852 0418-0143 439 µM -0.355460591506297 0.368373934392092 no 2137 0.361122281559097 3137 5369229 SGTC_33 0986-0033 35.816 µM -0.355899950908807 0.368211088211624 no 2138 0.360957746282473 3071 2848082 SGTC_2491 paeonol 100 µM -0.356539426799741 0.367974112252919 no 2139 0.3607183155545 2978 11092 Increases levels of cortical cytochrome oxidase. SGTC_233 rapamycin 362 pM -0.361249791134957 0.366230106222498 no 2140 0.358956361855213 3080 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3313 9133968 57.047 µM -0.361669546903547 0.36607482560613 no 2141 0.358799493342935 3027 1494643 SGTC_1190 1486-1332 13 µM -0.362010142243007 0.365948844992497 no 2142 0.358672225672357 3099 4150046 SGTC_3204 9114183 49.47 µM -0.364608723093132 0.364988149337772 no 2143 0.357701751199909 2986 17027248 SGTC_81 0411-0046 9.971 µM -0.364904954663347 0.364878686153723 no 2144 0.357591177842556 3097 12925265 SGTC_632 0781-2353 4.65 µM -0.364994785838632 0.364845494006243 no 2145 0.35755764922461 3131 6811515 YHR007C ERG11 SGTC_776 4476-4378 112 µM -0.365420330280679 0.364688271337944 no 2146 0.357398833817021 3125 2892008 SGTC_887 0885-0007 9.62 µM -0.370437234629682 0.36283643584977 no 2147 0.355528367353479 3169 5719458 SGTC_2386 9075165 157.42 µM -0.37156472435119 0.362420697088653 no 2148 0.355108478722037 3085 16452277 SGTC_2774 tamoxifen 10.92 µM -0.372867415947033 0.36194055819374 no 2149 0.354623562147058 3086 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1318 1280-3875 124 µM -0.373811892128852 0.361592584141746 no 2150 0.35427213562264 3120 373245 SGTC_2540 epiandrosterone 100 µM -0.37593046568271 0.360812453151302 no 2151 0.353484295330065 3077 441302 A steroid. SGTC_2234 tolnaftate 200 µM -0.376295655852482 0.360678036078068 no 2152 0.35334855425982 3100 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_580 1123-0028 41 µM -0.376389132245321 0.360643632597094 no 2153 0.353313812111839 3065 1677248 YPR107C YTH1 SGTC_569 4130-2812 160 µM -0.377322602731951 0.360300135743296 no 2154 0.352966938455847 3118 743552 SGTC_894 0960-0238 55.9 µM -0.379433502561381 0.359523786559648 no 2155 0.352182987919192 3194 6741907 YDL195W SEC31 SGTC_248 streptozotocin 5.23457 mM -0.379849630567498 0.359370810792404 no 2156 0.352028519368376 3156 5300 DNA alkylating agent. SGTC_385 1494-0393 12.4 µM -0.379850800699201 0.359370380663756 no 2157 0.352028085044739 3108 3090647 SGTC_3061 glucosamine 200 µM -0.38042904931498 0.359157844101269 no 2158 0.351813477243741 3175 91431 and experimental redox chemotherapeutic SGTC_3185 9108267 49.47 µM -0.381109369427201 0.358907846735284 no 2159 0.351561047669586 3154 4910486 SGTC_1680 diphenhydramine 100 µM -0.383546780165319 0.358012667624556 no 2160 0.35065719582431 3098 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1870 st057514 26.5 µM -0.383663442599555 0.357969840955165 no 2161 0.350613955667782 3050 5393161 SGTC_1608 st001473 40.5 µM -0.384838677178251 0.357538513231843 no 2162 0.350178470809403 3077 7292267 SGTC_1559 coumarin 343 70.1 µM -0.386294249007051 0.357004549969558 no 2163 0.349639379611576 3243 108770 A hepatotoxic, DNA x-linker. SGTC_1703 st026983 48.3 µM -0.386675679143719 0.356864672054851 no 2164 0.349498161744578 3226 1104023 SGTC_928 2764-0428 58.7 µM -0.386702410634178 0.356854869814139 no 2165 0.349488265656391 3190 662578 SGTC_2553 4-methylesculetin 85.09 µM -0.387897455113527 0.356416752447981 no 2166 0.349045960748061 3149 5319502 SGTC_1568 digitonin 820 nM -0.389512292697982 0.355825034991785 no 2167 0.348448609498109 3255 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2618 avocadyne 43.43 µM -0.38965985278568 0.355770982522974 no 2168 0.348394043645389 3060 3015189 SGTC_299 1273-0059 1.44 µM -0.39122962931673 0.355196140217506 no 2169 0.347813754571192 3189 2848077 SGTC_630 4356-0227 183 µM -0.392416952360998 0.354761568666427 no 2170 0.347375081167568 3160 779312 SGTC_1388 3346-4487 254 µM -0.393563353709755 0.354342154104976 no 2171 0.346951720760125 3173 3345614 SGTC_1263 0774-1208 64.8 µM -0.394637414107853 0.353949365917936 no 2172 0.346555248776262 3271 906585 SGTC_1777 st045864 34.765 µM -0.395252950771934 0.353724331708977 no 2173 0.346328109105784 3178 4691462 SGTC_2377 9073351 62.6 µM -0.395347938203991 0.353689609778572 no 2174 0.34629306263791 3082 7337946 YHR072W ERG7 SGTC_1572 epiandrosterone 68.9 µM -0.39571629134488 0.353554972615285 no 2175 0.346157167881651 3055 441302 A steroid. SGTC_1923 st058458 19.1 µM -0.397106551141505 0.35304698239715 no 2176 0.345644444591526 3302 3534982 SGTC_386 1509-0011 3.07 µM -0.399868062647992 0.352038724553213 no 2177 0.344626848258822 3104 3107280 SGTC_1685 st024049 53.0905 µM -0.400258805420396 0.351896143899256 no 2178 0.344482953015454 3158 1941139 SGTC_211 3455-0679 143.504 µM -0.400452700243698 0.351825400094062 no 2179 0.344411557506669 3202 748649 SGTC_490 phenamil 164 µM -0.400759861317677 0.351713340850958 no 2180 0.34429846670526 3159 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_942 3253-1115 227 µM -0.402636769577605 0.351028882837034 no 2181 0.343607727915306 3298 46497897 SGTC_2642 cholecalciferol 100 µM -0.402650918586962 0.351023724905193 no 2182 0.34360252278339 3199 9821465 A vitamin D precursor, similar to steriods. SGTC_1831 st055328 12 µM -0.402652681981934 0.351023082072637 no 2183 0.34360187406843 3224 1103068 SGTC_3064 1327-0027 10 µM -0.403008144528367 0.350893509545409 no 2184 0.343471116474564 3091 16000455 YPR107C YTH1 SGTC_1475 4092-1048 11.7 µM -0.403220421364799 0.350816139066809 no 2185 0.343393038956251 3195 2881759 SGTC_3265 9137266 49.47 µM -0.403899109019176 0.350568813094484 no 2186 0.343143455782309 3177 17224265 SGTC_2239 6685329 187.64 µM -0.404868056698207 0.350215820922773 no 2187 0.342787249855876 3236 805680 SGTC_302 1094-0063 18.9 µM -0.405224944456145 0.350085837624368 no 2188 0.342656085461237 3100 5440289 SGTC_2245 6637752 200 µM -0.405827603398289 0.349866381045071 no 2189 0.342434637613871 3211 681890 SGTC_2694 st077685 81.9 µM -0.406656501915543 0.349564621879727 no 2190 0.342130146205262 3059 2838096 SGTC_1138 3761-0006 1.03 µM -0.406835138466206 0.349499601973081 no 2191 0.342064538464852 3203 12061087 SGTC_1760 st045453 10.4495 µM -0.406976861340804 0.349448021000666 no 2192 0.34201249138019 3247 3323419 YIL048W NEO1 SGTC_1540 guanosine 70.6 µM -0.408013940558103 0.349070653853953 no 2193 0.341631720140259 3168 6802 Guanosine is a purine nucleoside SGTC_613 3914-0030 117 µM -0.408544702614364 0.348877580533419 no 2194 0.341436909254642 3037 1145395 SGTC_1973 st070275 50.2 µM -0.40899913369337 0.34871230493143 no 2195 0.341270148449714 3190 17118334 SGTC_1665 st014639 11.4 µM -0.409217981095463 0.348632720843454 no 2196 0.341189849924719 3182 981133 YIL048W NEO1 SGTC_2985 9022375 71.43 µM -0.410355196682052 0.348219278506155 no 2197 0.340772703631419 3306 4939335 SGTC_1473 k844-0725 134 µM -0.410682753073321 0.348100226613849 no 2198 0.3406525875313 3183 54682906 SGTC_2081 5214970 32.255 µM -0.411186891716154 0.347917024333401 no 2199 0.340467749661922 3225 2063512 SGTC_1769 st044406 64.4 µM -0.413744006612572 0.34698832484652 no 2200 0.339530797453857 3113 670903 SGTC_328 k915-0120 63.5 µM -0.41467617465943 0.346650005792178 no 2201 0.339189488003977 3233 6624543 SGTC_1097 itavastatin 7.23 µM -0.415798056104677 0.346242994701032 no 2202 0.338778890712063 3159 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2087 5276107 200 µM -0.41672270672724 0.345907671053236 no 2203 0.338440621844442 3101 144405 SGTC_2859 9028643 45.46 µM -0.417401318332293 0.34566165007074 no 2204 0.33819244537996 3177 17151580 SGTC_1387 3342-1166 1.8 µM -0.418912549413665 0.345114009021604 no 2205 0.337640022598852 3177 3418228 SGTC_2198 6589944 200 µM -0.419159738277652 0.345024463359211 no 2206 0.337549697217796 3198 5290268 SGTC_859 0439-0102 54.6 µM -0.420458719689601 0.344554042204402 no 2207 0.337075189813868 3271 610143 SGTC_902 1120-0002 2.07 µM -0.420719640099207 0.344459579834315 no 2208 0.336979908925181 3140 3280475 SGTC_3011 9081274 71.4286 µM -0.421970999649726 0.344006678549068 no 2209 0.336523092619341 3152 6625322 SGTC_3245 9134821 49.47 µM -0.42391967006816 0.343301846966252 no 2210 0.335812199182266 3159 17014901 SGTC_2537 larixol 68.93 µM -0.424070829632083 0.343247195479929 no 2211 0.335757079245821 3247 6708759 SGTC_2671 danthron 100 µM -0.425251593611084 0.342820405137867 no 2212 0.335326638448081 3206 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1362 1611-0397 101 µM -0.425293486495616 0.34280526652129 no 2213 0.335311370601409 3164 27816 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.425806169877513 0.342620021212244 no 2214 0.335124545368771 3100 6708514 SGTC_357 1325-0123 420 µM -0.428155326874434 0.341771696674044 no 2215 0.334269019084182 3247 1098503 SGTC_2764 methyldopa 94.69 µM -0.42906258139469 0.341444283571312 no 2216 0.333938841167886 3333 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2346 9031566 143.75 µM -0.42920793295227 0.341391839686403 no 2217 0.333885955187926 3197 4771086 SGTC_234 nsc-17383 10.7 µM -0.43080651726934 0.340815261253534 no 2218 0.333304530187313 3301 408974 SGTC_1287 0971-0001 34.6 µM -0.431189364012142 0.340677230954805 no 2219 0.333165343429996 3196 4665869 SGTC_3269 9137823 49.47 µM -0.431570705867992 0.340539764428805 no 2220 0.333026726625097 3135 17682936 SGTC_2689 tacrolimus 100 µM -0.433310504295025 0.339912868988666 no 2221 0.332394603960565 3221 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1694 st024011 44.9 µM -0.433341940574538 0.339901545729067 no 2222 0.332383186563121 3260 2787533 SGTC_541 4513-1321 94 µM -0.43354872363107 0.339827066653077 no 2223 0.332308088539259 3183 747515 SGTC_1366 1683-0113 21.9 µM -0.433892571460273 0.339703233460515 no 2224 0.332183227196302 3159 708623 SGTC_801 0866-0028 10.1 µM -0.434110263841832 0.339624842772853 no 2225 0.332104186266076 3128 6849771 SGTC_2493 resveratrol 26.09 µM -0.434524676459099 0.339475632609379 no 2226 0.331953739731948 3159 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2449 5812982 45.77 µM -0.435376446571654 0.339169029951591 no 2227 0.331644601936865 3255 776185 SGTC_118 0083-0097 135.343 µM -0.435377810051545 0.33916853923949 no 2228 0.331644107173153 3240 5207356 SGTC_41 0478-0632 82.643 µM -0.436704626399479 0.338691151645598 no 2229 0.331162786819793 3290 3750424 SGTC_1395 3486-0190 4.35 µM -0.438709863706467 0.33797016040204 no 2230 0.330435889517304 3339 6748079 SGTC_2811 7967822 32.47 µM -0.438816326308312 0.337931897922463 no 2231 0.330397314736854 3301 2232244 SGTC_1702 st027038 51 µM -0.439385998751084 0.337727187067362 no 2232 0.330190934954673 3237 5521182 SGTC_591 4299-0174 154 µM -0.4404570501298 0.337342436508007 no 2233 0.32980305651281 3201 5509088 SGTC_1514 1189-1591 158 µM -0.442691531863053 0.336540298103612 no 2234 0.328994434188389 3344 767698 YMR146C TIF34 SGTC_1499 4480-0877 67.3 µM -0.443461130533372 0.336264198037791 no 2235 0.328716113974061 3218 2861909 SGTC_2344 7990960 76.95 µM -0.443833093660729 0.336130784742524 no 2236 0.328581630030729 3203 140813 SGTC_95 0471-0001 561.058 µM -0.444868243775852 0.33575961256933 no 2237 0.328207486533403 3203 4015405 SGTC_2152 5568786 200 µM -0.445145198467077 0.335660332498255 no 2238 0.328107413535718 3238 5399883 SGTC_777 1315-0167 517 µM -0.445330837839075 0.335593792690725 no 2239 0.328040342724127 3244 4221767 SGTC_2274 7947094 46.08 µM -0.445638102784093 0.335483669245528 no 2240 0.327929341231813 3230 2971028 SGTC_226 1,3-diallylurea 8.28947 mM -0.447922927035096 0.334665234337338 no 2241 0.32710441062933 3257 74537 YKL182W FAS1 SGTC_3261 9137475 49.47 µM -0.449431687480843 0.334125219170611 no 2242 0.326560138464986 3202 17027690 SGTC_1779 st039427 55 µM -0.449701274648318 0.334028764707253 no 2243 0.326462926069059 3385 1124498 SGTC_1986 st071812 45 µM -0.454076434642448 0.332464931002175 no 2244 0.324886906902581 3272 11838594 SGTC_2302 7771753 200 µM -0.454642138020338 0.332262941034057 no 2245 0.324683357213153 3260 2203047 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.454801137559245 0.332206177448896 no 2246 0.324626155898344 3307 688662 SGTC_3272 9137413 49.47 µM -0.455595093054896 0.331922789217051 no 2247 0.324340586181113 3227 17614870 SGTC_271 rotenone 740 µM -0.456346428077108 0.331654702119974 no 2248 0.324070441293815 3331 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1976 st070609 63.5 µM -0.456372877233986 0.331645266251893 no 2249 0.324060933102391 3210 682556 SGTC_1735 st034310 56.75 µM -0.457651759271322 0.331189146289387 no 2250 0.323601325608861 3347 871153 SGTC_1405 3909-7894 12 µM -0.460194368907334 0.330283055454797 no 2251 0.322688356255454 3298 7104060 SGTC_2151 5563267 85.4165 µM -0.460348191884817 0.330228270551007 no 2252 0.322633157572989 3237 5310824 SGTC_747 3448-8087 38.7 µM -0.461282711565215 0.329895514456297 no 2253 0.322297893437818 3229 5168703 SGTC_2143 5623677 140.463 µM -0.461626646277878 0.329773082868528 no 2254 0.322174541308756 3291 5375313 SGTC_614 0462-0418 107 µM -0.461898018567088 0.329676494439399 no 2255 0.322077227502033 3230 5188303 SGTC_1458 k015-0034 6.33 µM -0.4653322512014 0.328455145348266 no 2256 0.320846771186343 3261 3598957 SGTC_2701 st077767 14.721 µM -0.465344878791621 0.32845065784776 no 2257 0.320842250446796 3262 5721188 SGTC_378 3970-0959 8.33 µM -0.466296102749309 0.328112690029627 no 2258 0.320501783991634 3309 6615653 SGTC_1270 0831-1170 17.3 µM -0.466987831253465 0.327867008708368 no 2259 0.320254292146598 3313 6764716 SGTC_29 0299-0004 12.984 µM -0.46727908649358 0.32776358581454 no 2260 0.320150108557114 3247 16871 A napthoquinone isolated from Swertia calycina. SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.467403964628158 0.327719246424539 no 2261 0.32010544330892 3237 689007 SGTC_47 0149-0135 24.25 µM -0.467867969378974 0.327554517589562 no 2262 0.3199395052546 3209 5239155 SGTC_55 0767-0285 6.563 µM -0.468501229494471 0.327329754657775 no 2263 0.319713095980944 3328 3116166 SGTC_2166 5933061 31.504 µM -0.469235212345031 0.327069320529884 no 2264 0.319450759381745 3613 2877375 SGTC_2014 4013930 200 µM -0.46928628095018 0.327051203336256 no 2265 0.319432510048035 3344 64556 SGTC_2825 7998094 58.44 µM -0.469743940908876 0.326888861232523 no 2266 0.319268985078034 3245 2987815 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.469817464685959 0.326862783777021 no 2267 0.319242717816271 3195 5711223 A potent inhibitor of glutathione S-transferases. SGTC_12 0849-0099 9.267 µM -0.471182400968232 0.326378821068713 no 2268 0.318755242654058 3289 6071388 SGTC_366 0181-0206 4.31 µM -0.472085159370548 0.326058892292403 no 2269 0.318433002464856 3425 274874 SGTC_2340 7987427 183.45 µM -0.473244955510548 0.325648059710206 no 2270 0.31801921402752 3322 2239331 SGTC_1008 4106-0037 6 µM -0.474632440873816 0.325156851282624 no 2271 0.317524489668825 3233 2905394 SGTC_1883 5-benzylidenerhodanine 20 µM -0.475972036119018 0.324682885401711 no 2272 0.317047150114557 3322 1273210 SGTC_56 0957-0365 83.25 µM -0.480312858869786 0.323148999487971 no 2273 0.315502473364522 3330 6752360 SGTC_2467 5474540 200 µM -0.481378011374663 0.322773071776342 no 2274 0.31512393079742 3222 5413519 SGTC_653 0203-0016 55.2 µM -0.483061583004953 0.322179252730962 no 2275 0.314526005278503 3279 295302 SGTC_1004 4084-0029 199 µM -0.483853850331482 0.321899965921373 no 2276 0.314244797271705 3356 716894 YLR208W SEC13 SGTC_573 3702-0553 84.7 µM -0.485357899608501 0.321370041474297 no 2277 0.313711245431737 3280 1222756 SGTC_1076 itraconazole 331 nM -0.486002225415964 0.321143136099089 no 2278 0.313482794053177 3326 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2424 5537928 59.2 µM -0.48602308772247 0.321135790357566 no 2279 0.313475398334099 3255 5382802 SGTC_3218 9131285 49.47 µM -0.486308850243475 0.321035178729647 no 2280 0.31337410263946 3426 17156417 SGTC_338 4055-0136 114 µM -0.488523970262321 0.320255722581522 no 2281 0.312589375708968 3248 2900563 SGTC_965 1291-5240 308 µM -0.490656422460494 0.319506104037442 no 2282 0.311834736394587 3375 2834598 SGTC_2863 9028737 58.44 µM -0.493183861908308 0.318618590470361 no 2283 0.310941339846462 3289 6460917 SGTC_2400 5203494 178.7 µM -0.493646706862804 0.318456174346613 no 2284 0.310777854352392 3340 6777674 SGTC_2050 5263056 171 µM -0.496751316609811 0.317367644082878 no 2285 0.309682214913595 3387 763468 YGL055W OLE1 SGTC_442 cape 100 µM -0.498201530446243 0.316859713837663 no 2286 0.309171001929079 3372 5281787 SGTC_1147 3809-1045 12.3 µM -0.498280825155236 0.316831951196083 no 2287 0.309143060493425 3295 325925 SGTC_900 1112-0045 141 µM -0.499322480230187 0.316467343030409 no 2288 0.308776110333849 3299 56211 YIL048W NEO1 SGTC_2585 alliin 100 µM -0.501245769906813 0.315794607021934 no 2289 0.308099083018007 3451 87310 A garlic compound which reacts with lipids. SGTC_647 0140-0236 81 µM -0.501747909406767 0.315619066935928 no 2290 0.307922429570741 3312 990837 SGTC_216 k038-0035 28.382 µM -0.501765114026996 0.31561305320752 no 2291 0.307916377747227 3344 4444231 YPR107C YTH1 SGTC_1056 3448-1962 115 µM -0.502267993143747 0.315437297673293 no 2292 0.307739510229386 3354 715507 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.50295223771727 0.315198222223882 no 2293 0.30749892644481 3436 688751 SGTC_3333 9141820 12.094 µM -0.50468448872348 0.314593318799013 no 2294 0.306890228655714 3265 1939433 SGTC_232 clozapine 119 µM -0.505485671375967 0.314313713273572 no 2295 0.306608879926402 3332 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_949 1165-0505 146 µM -0.507590001491261 0.313579828589948 no 2296 0.305870452001783 3267 6244267 SGTC_105 0111-0055 734.78 µM -0.508672188729561 0.313202702877066 no 2297 0.305491009787027 3339 5179370 SGTC_2911 7942208 15.64 µM -0.508737183865148 0.313180059278499 no 2298 0.305468227492745 3358 1243384 SGTC_1251 0490-5699 265 µM -0.510370047492613 0.312611418682589 no 2299 0.304896118500007 3461 3883818 SGTC_470 aa-861 153 µM -0.510581513971768 0.31253780859651 no 2300 0.304822061490229 3324 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2266 7929956 200 µM -0.510983103895676 0.312398038381244 no 2301 0.304681443959539 3386 2967153 SGTC_2100 5377183 190 µM -0.511373452791952 0.312262206380682 no 2302 0.304544790149869 3339 2844202 SGTC_564 3555-0129 330 µM -0.511585490945794 0.312188432909436 no 2303 0.304470571009766 3350 563260 SGTC_471 1-acyl-paf 4 µM -0.513041440800236 0.311682074390065 no 2304 0.303961166382874 3273 16759367 SGTC_1889 st059080 5.18 µM -0.513740132956041 0.311439205558409 no 2305 0.303716844477421 3424 176925 Isolated from Daphnopsis sellowiana. SGTC_814 3342-0569 96 µM -0.517441744164966 0.310153877845389 no 2306 0.302423912840877 3445 4346283 SGTC_1919 st067113 52.3 µM -0.518708180490999 0.309714658176796 no 2307 0.301982128088783 3390 1268243 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.518829958353926 0.309672438035699 no 2308 0.301939662274517 3396 616764 SGTC_2293 7624732 200 µM -0.519156994399633 0.309559067721708 no 2309 0.301825633052888 3356 894453 SGTC_3081 9117243 49.47 µM -0.520771006014134 0.308999819998079 no 2310 0.301263151605145 3438 45595589 SGTC_2880 9042983 58.44 µM -0.521499740433512 0.308747461710881 no 2311 0.301009343175218 3415 6464714 SGTC_1839 st053978 48 µM -0.523743960866 0.307970863225167 no 2312 0.300228317512077 3415 3788398 SGTC_3018 9082602 49.47 µM -0.524732720549758 0.307628981543307 no 2313 0.299884503849762 3425 17332089 SGTC_353 1988-1175 58.3 µM -0.525549501030046 0.307346690741663 no 2314 0.299600625664128 3267 2788357 SGTC_138 0850-0259 40.9225 µM -0.525743474528482 0.307279667536218 no 2315 0.299533226616051 3435 6813004 SGTC_1180 1193-0155 285 µM -0.526549327309411 0.307001292057894 no 2316 0.299253294396309 3409 2921347 SGTC_2461 5755302 26.15 µM -0.528067443390999 0.306477173058321 no 2317 0.298726263193079 3437 2788904 SGTC_1501 4491-0275 38.4 µM -0.528694488962506 0.306260805329598 no 2318 0.298508700413178 3408 5104718 SGTC_2965 9082772 38.63 µM -0.528755788212221 0.306239657094131 no 2319 0.298487435595946 3464 16459634 SGTC_422 cantharidin 155 µM -0.529103309660558 0.306119774433045 no 2320 0.298366892827571 3355 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_140 0062-0056 502.533 µM -0.530201170283959 0.305741187613015 no 2321 0.297986229869082 3311 3758964 SGTC_2190 6049624 200 µM -0.531684530930289 0.305229994428513 no 2322 0.29747225377992 3369 2265554 SGTC_1274 0865-0114 173 µM -0.531983553224189 0.305126991833238 no 2323 0.297368693291402 3355 870624 SGTC_97 0535-0701 19.132 µM -0.532598190266529 0.304915319601597 no 2324 0.297155877579692 3401 2832013 YGL099W LSG1 SGTC_2149 5554786 194.827 µM -0.5327569652517 0.304860650365926 no 2325 0.297100913670275 3347 745063 YPR165W RHO1 SGTC_2575 plumbagin 510 nM -0.532979589783425 0.304784003857802 no 2326 0.297023854482198 3319 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2034 5197015 53.07 µM -0.533236471551755 0.304695573708658 no 2327 0.296934948866229 3443 780676 SGTC_1373 2887-0003 58.5 µM -0.53362880509466 0.304560537046857 no 2328 0.296799187508048 3337 776948 SGTC_2112 5488546 200 µM -0.533990088899961 0.304436210897505 no 2329 0.296674195598225 3326 600757 SGTC_283 0987-0079 11.7 µM -0.534698286803391 0.304192569112493 no 2330 0.296429253175027 3428 411556 SGTC_42 0133-0086 60.653 µM -0.536572669619492 0.30354814358859 no 2331 0.295781413403821 3343 162923 Model of phenazepam hydroxylation. SGTC_3278 9139605 49.47 µM -0.537246874269236 0.303316496632235 no 2332 0.295548548353834 3471 7958859 SGTC_1573 oleylamine 1.06 µM -0.537275526457438 0.303306653905665 no 2333 0.295538653978126 3414 5356789 An amine of the fatty acid oleic acid. SGTC_1168 k815-0004 80.5 µM -0.538687900276391 0.302821646081 no 2334 0.295051112011026 3327 642433 SGTC_1339 1486-1321 22.7 µM -0.538942952572169 0.302734098397477 no 2335 0.294963109175257 3359 3469382 SGTC_1529 apigenin 74 µM -0.539384559609396 0.302582541895356 no 2336 0.29481076639522 3504 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1450 4112-4260 37.6 µM -0.540025113412546 0.302362768686383 no 2337 0.294589856717693 3455 1633175 SGTC_1733 st037357 54.9 µM -0.540128240324532 0.302327392664426 no 2338 0.294554298174473 3318 1272339 YGL099W LSG1 SGTC_1828 st055811 49 µM -0.540405108310367 0.302232426757782 no 2339 0.294458842859494 3422 5877589 SGTC_3090 9117696 49.47 µM -0.541103551799898 0.301992919670138 no 2340 0.294218105124957 3343 7923821 SGTC_2106 5357045 167.29 µM -0.541681385176532 0.301794836121949 no 2341 0.294019007734182 3390 668842 SGTC_1619 st003326 88.7 µM -0.544302079157226 0.300897185980457 no 2342 0.293116808213038 3434 2849032 SGTC_231 b-estradiol 524 µM -0.54598614103446 0.300320990907799 no 2343 0.292537731899218 3319 450 A steroid. SGTC_2385 9074692 200 µM -0.546733194825087 0.300065549189935 no 2344 0.292281022629448 3373 17046906 SGTC_2910 7948405 25.97 µM -0.547842615475871 0.299686384059329 no 2345 0.291899987098778 3438 2971328 SGTC_1063 disulfiram 1.84 µM -0.548008971090858 0.299629547652326 no 2346 0.291842871464496 3409 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2331 7980721 200 µM -0.5480139916725 0.299627832416015 no 2347 0.291841147806169 3365 2981221 SGTC_1332 1480-0653 17.5 µM -0.549274484090218 0.299197337432426 no 2348 0.291408547638132 3433 5749438 SGTC_2766 oltipraz 83.91 µM -0.549411413059883 0.29915058909549 no 2349 0.291361571726566 3461 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2136 5328288 199.296 µM -0.549481449741132 0.299126679451687 no 2350 0.291337545766893 3347 262395 SGTC_1301 naphtanilide LB 4.81 µM -0.551306971052529 0.298503775611782 no 2351 0.290711630283212 3481 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_650 1328-0195 38 µM -0.551758675420762 0.298349736303996 no 2352 0.290556851770215 3438 2780821 SGTC_944 3370-0224 231 µM -0.55210608995806 0.298231286325533 no 2353 0.290437834872017 3395 4580514 SGTC_52 0329-0193 875 nM -0.554547100424304 0.297399635436526 no 2354 0.289602240334774 3532 3739292 SGTC_2941 9056145 11.23 µM -0.554956637329839 0.297260210277602 no 2355 0.289462160337771 3418 2119517 SGTC_1045 1348-1485 165 µM -0.555351095436401 0.297125946882372 no 2356 0.289327268062962 3437 6810614 SGTC_1302 1159-0335 255 µM -0.559183709633912 0.29582286954841 no 2357 0.288018174849178 3404 649284 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.560311130775744 0.295440050023097 no 2358 0.287633618253352 3438 688669 SGTC_1824 st053723 68.6 µM -0.560733406369839 0.295296723649963 no 2359 0.28748964507477 3406 675225 SGTC_2051 5263410 176 µM -0.560755199864919 0.295289327494621 no 2360 0.287482215594438 3511 227584 SGTC_2319 6033012 152.6 µM -0.561285810183028 0.295109278224484 no 2361 0.287301356663038 3333 847246 SGTC_1005 4092-0690 4.4 µM -0.561346628028017 0.295088644447849 no 2362 0.28728063029378 3382 1529343 SGTC_2246 7293507 91.5585 µM -0.561977177826824 0.294874755881209 no 2363 0.287065784282656 3465 887656 SGTC_3328 9140624 29.0385 µM -0.562398995663285 0.294731711108386 no 2364 0.286922101597479 3473 4904392 SGTC_354 2783-3500 4.88 µM -0.566057514205117 0.293492396985454 no 2365 0.2856773417468 3384 6740761 SGTC_1950 st077106 7.18 µM -0.566580564547074 0.293315412357189 no 2366 0.285499591306202 3406 13831864 SGTC_1736 st036774 51 µM -0.568694591144732 0.292600593295219 no 2367 0.284781709544123 3531 1272247 SGTC_1195 1502-0147 41.1 µM -0.569048048617385 0.292481157196024 no 2368 0.284661766457947 3469 817940 SGTC_901 1112-0062 60.1 µM -0.570106412598597 0.292123663147037 no 2369 0.284302763041389 3443 1908457 SGTC_1316 1272-0050 65.9 µM -0.570543546899662 0.291976067343473 no 2370 0.284154547638123 3478 7340392 SGTC_1118 chelidonine 707.474 nM -0.571460650663793 0.291666525593577 no 2371 0.283843713215671 3501 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_435 c-PAF 6.7 µM -0.572571274791867 0.291291871584814 no 2372 0.283467506896069 3428 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2498 4'-Methoxychalcone 54.63 µM -0.573101901852976 0.291112951062119 no 2373 0.283287849798271 3385 641818 YHR062C RPP1 SGTC_1311 1190-0148 100 µM -0.57329512907844 0.291047810112888 no 2374 0.283222441441669 3501 1961333 SGTC_2161 5662504 8.5105 µM -0.575124724831517 0.290431352759393 no 2375 0.282603473689497 3427 2859334 SGTC_987 1497-1013 404 µM -0.577129682037725 0.28975651251711 no 2376 0.281925927265031 3482 1676435 SGTC_1322 1348-1070 12 µM -0.579774544639207 0.2888674163258 no 2377 0.281033332894304 3486 6758089 SGTC_1250 0485-0349 40.2 µM -0.58233447039167 0.288008097245041 no 2378 0.280170705665494 3419 6842794 YDL195W SEC31 SGTC_163 TUB2.036 7.546 µM -0.582541926373435 0.287938511050996 no 2379 0.280100854727156 3470 15992207 YJR013W GPI14 SGTC_2369 9071472 200 µM -0.583831255466212 0.287506214230753 no 2380 0.279666923785808 3491 17296037 SGTC_818 4072-2707 53.5 µM -0.583864397231691 0.287495106234949 no 2381 0.279655774041022 3445 882871 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.584724462282795 0.287206912591396 no 2382 0.279366501444708 3514 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1971 st069429 63.5 µM -0.585207628790931 0.287045071455866 no 2383 0.279204057960016 3495 1246522 YGL099W LSG1 SGTC_2399 5884133 200 µM -0.585663608571374 0.286892376393076 no 2384 0.279050796937593 3436 722445 SGTC_1574 spiramycin 23.7 µM -0.586619539406727 0.286572386480612 no 2385 0.278729628397648 3482 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1744 st037937 38.9 µM -0.588850825827139 0.285826141359218 no 2386 0.277980673640886 3533 1016152 SGTC_2140 5586273 200 µM -0.589381144667028 0.285648914284273 no 2387 0.27780281109329 3494 854421 SGTC_1222 0366-0074 1.18 µM -0.589444766694668 0.285627655973508 no 2388 0.277781476765528 3530 286520 SGTC_2158 5657123 3.6195 µM -0.592758560374418 0.284521445536798 no 2389 0.276671372170438 3479 2858827 SGTC_693 4161-2696 114 µM -0.593731328161408 0.284197105185575 no 2390 0.276345912987334 3489 805759 SGTC_2525 harmine 47.85 µM -0.595091075517728 0.283744034545053 no 2391 0.275891296911856 3432 5280953 A monoamine oxidase inhibitor SGTC_607 4491-0986 66.8 µM -0.595355933148944 0.283655823696714 no 2392 0.275802787544187 3540 698981 YDR232W HEM1 SGTC_1217 1183-1422 255 µM -0.595747427672565 0.283525460487916 no 2393 0.275671984581695 3525 2849664 SGTC_2740 felodipine 17.08 µM -0.597238634979217 0.283029168603087 no 2394 0.275174034027831 3479 3333 L-type calcium channel blocker SGTC_1723 st034307 2.5525 µM -0.601001127977373 0.281778821944187 no 2395 0.273919617506042 3508 867466 SGTC_1780 st038448 24.544 µM -0.601232928176786 0.281701877557971 no 2396 0.27384242777614 3550 728868 YDL195W SEC31 SGTC_3262 9137218 49.47 µM -0.60194114269885 0.281466853683683 no 2397 0.273606658185347 3408 17650664 SGTC_888 0916-0002 6.97 µM -0.602053640147618 0.281429529656231 no 2398 0.273569216241076 3560 2802138 YIL048W NEO1 SGTC_754 3474-0146 171 µM -0.603069219729984 0.281092692200756 no 2399 0.27323132095377 3405 24762078 SGTC_980 1473-0395 201 µM -0.604599305268743 0.280585576507371 no 2400 0.272722634197494 3495 768876 SGTC_2918 7977171 22.06 µM -0.605240525456099 0.280373188846318 no 2401 0.272509596249831 3481 2236483 SGTC_1141 3253-0389 52.6 µM -0.60655572249503 0.279937807457143 no 2402 0.272072896046657 3509 5402031 SGTC_2265 7929201 200 µM -0.606671870403065 0.279899373740627 no 2403 0.272034346830541 3502 1265108 SGTC_375 3970-0961 9.27 µM -0.607403140742017 0.279657452824924 no 2404 0.271791702333199 3464 2898222 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.607442565582212 0.27964441307176 no 2405 0.271778623746561 3498 2333 A French combination drug. SGTC_690 glyoxal 20.3 µM -0.608577926528176 0.279269019479683 no 2406 0.271402119586413 3468 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_671 0560-0003 407 µM -0.609822708346726 0.278857728807892 no 2407 0.270989628556361 3452 3238678 SGTC_272 doxorubicin 8.13 µM -0.610394285069847 0.278668971875633 no 2408 0.270800326486532 3539 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1563 conessine 56.1 µM -0.611879242128765 0.278178872081477 no 2409 0.270308828191052 3585 441082 An anti-amoebic, histamine inhibitor. SGTC_1684 st024538 14.6195 µM -0.613483414389365 0.277649898902794 no 2410 0.269778373062124 3490 6732859 SGTC_1059 3448-6867 171 µM -0.614196809351589 0.277414816032257 no 2411 0.269542640765847 3530 3934407 SGTC_1259 0671-0132 43 µM -0.6173734533781 0.27636920908808 no 2412 0.268494213872728 3465 X1259 SGTC_1288 0973-0013 65.5 µM -0.61771031711805 0.276258442313029 no 2413 0.268383154939551 3556 4315430 SGTC_2722 naftopidil 47.16 µM -0.618217553553094 0.276091695079413 no 2414 0.268215970273925 3522 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1716 st033144 30.6155 µM -0.620351268978109 0.275390806088153 no 2415 0.267513273948509 3585 674617 SGTC_1133 3473-0247 50 µM -0.621231708453973 0.275101852166188 no 2416 0.267223589680779 3471 711311 SGTC_2802 7925815 54.55 µM -0.621438887665666 0.275033879143172 no 2417 0.267155446106549 3522 1262923 SGTC_1298 1079-1278 263 µM -0.621723824109124 0.274940408417321 no 2418 0.267061741633722 3560 2840950 SGTC_1297 1068-0111 14.1 µM -0.623802107048011 0.274259121031596 no 2419 0.266378777857013 3515 767057 SGTC_1491 4138-0063 26.5 µM -0.625639872889201 0.273657373511229 no 2420 0.26577558973828 3534 23883227 SGTC_1943 st076331 65.2 µM -0.626894563296661 0.273246920424924 no 2421 0.265364175639635 3613 24208415 SGTC_3244 9134489 49.47 µM -0.627025438096476 0.27320412427474 no 2422 0.26532128030009 3529 16584271 SGTC_2242 6630449 61.2675 µM -0.627231476203606 0.273136756401119 no 2423 0.265253756674013 3541 691249 YDR170C SEC7 SGTC_2011 4012611 177 µM -0.627558468627258 0.273029857235452 no 2424 0.265146611333026 3546 2049887 SGTC_1414 3917-0015 5.4 µM -0.627631368524414 0.273006027895637 no 2425 0.265122727279876 3547 6618702 SGTC_83 0170-0301 39.027 µM -0.628789819063116 0.272627494854306 no 2426 0.264743333066034 3515 3089716 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.629360175434632 0.272441222068348 no 2427 0.264556642006767 3549 6708784 An antioxidant flavonoid SGTC_1295 1013-0063 9.78 µM -0.629428258392353 0.272418991066955 no 2428 0.264534361328562 3566 6826038 SGTC_396 dithiazanine 1.25 µM -0.629699950877297 0.272330284798529 no 2429 0.264445457354808 3508 10578 An antihelmenthic. SGTC_634 1611-4317 11.2 µM -0.630212512186678 0.272162975118742 no 2430 0.264277777025458 3584 2843522 SGTC_1167 k781-0610 148 µM -0.631394338490565 0.27177739954288 no 2431 0.263891358445025 3579 4525169 SGTC_2688 kanamycin b 96.69 µM -0.631403443025711 0.271774430207267 no 2432 0.263888382677955 3681 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2039 Aminomethylbenzodioxan 200 µM -0.631927751759345 0.271603460404903 no 2433 0.263717044124564 3543 15053 SGTC_1170 0310-0127 64.8 µM -0.632214058312806 0.271510122423168 no 2434 0.2636235061263 3533 774975 SGTC_948 3448-0295 75.3 µM -0.63333293352539 0.271145514395432 no 2435 0.263258125554761 3593 678569 SGTC_2508 celastrol 40.54 µM -0.636567456621383 0.270092854889125 no 2436 0.262203314317915 3537 122724 Celastrol is a natural product and antioxidant. SGTC_2834 9001755 58.44 µM -0.637460562731578 0.269802558541027 no 2437 0.261912445193709 3477 2989575 SGTC_3009 9080819 71.4286 µM -0.638648966499486 0.269416520673311 no 2438 0.261525659489124 3561 17027216 SGTC_2425 5628681 7.85 µM -0.639020508770409 0.269295886729102 no 2439 0.261404795096559 3577 5714958 SGTC_2063 5246145 200 µM -0.639624112869158 0.269099963720025 no 2440 0.261208501110047 3599 711240 SGTC_2739 tacrine 100.86 µM -0.640338854920116 0.268868059130498 no 2441 0.260976162690421 3588 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2213 7173844 200 µM -0.641669763897322 0.268436501142679 no 2442 0.260543812627794 3561 892728 SGTC_2850 9015429 58.44 µM -0.641848435287443 0.268378592030034 no 2443 0.260485798741291 3557 6457570 SGTC_2786 7743617 45.45 µM -0.643884031185498 0.267719279709798 no 2444 0.259825318804185 3492 583674 SGTC_439 amiodarone 34.4 µM -0.644467555310072 0.267530431809025 no 2445 0.259636145030965 3519 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1476 4112-3294 3.34 µM -0.645231583481098 0.267283268357409 no 2446 0.259388560854635 3626 704369 SGTC_831 k061-1017 217 µM -0.645775466829847 0.267107392086314 no 2447 0.259212389196412 3623 1240153 SGTC_907 3448-6986 75.5 µM -0.64665789543291 0.266822164346676 no 2448 0.258926689475922 3636 590582 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.646737805366513 0.26679634262945 no 2449 0.258900825461907 3541 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1561 5-methoxyflavone 52.9 µM -0.647565396043878 0.266528993183258 no 2450 0.258633042305743 3567 94525 SGTC_2890 9046729 58.44 µM -0.649865578413177 0.265786641929864 no 2451 0.257889527159524 3507 903329 SGTC_3032 9089427 49.47 µM -0.649894925434431 0.265777177370344 no 2452 0.257880048145106 3576 17173707 SGTC_321 4534-3890 65.3 µM -0.649954100629169 0.265758093596894 no 2453 0.257860935255104 3596 699746 SGTC_1331 1472-0049 76.2 µM -0.651479768225598 0.265266311592592 no 2454 0.257368416516458 3569 24051409 SGTC_1233 0325-0408 14.2 µM -0.652997273555023 0.264777619330457 no 2455 0.256879018106275 3613 12874 SGTC_482 fipronil 114 µM -0.655148378580893 0.264085669959944 no 2456 0.256186113261813 3627 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2809 7964133 12.99 µM -0.656337391637082 0.263703593991007 no 2457 0.255803532051613 3591 1253665 SGTC_3235 9132602 49.47 µM -0.656406580900663 0.263681369483635 no 2458 0.255781278645636 3628 4912240 SGTC_604 1000-0114 314 µM -0.657130641643643 0.263448848918879 no 2459 0.255548458968048 3638 1572745 SGTC_2790 5423970 71.43 µM -0.657360137263486 0.263375171909675 no 2460 0.255474688413787 3626 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2148 5546263 113.568 µM -0.657677733963462 0.263273228387261 no 2461 0.255372616436114 3586 792097 SGTC_3126 9127922 49.47 µM -0.658250628119069 0.263089389391666 no 2462 0.255188548665709 3634 45595682 SGTC_2431 5490079 200 µM -0.659570491714893 0.262666101269296 no 2463 0.254764747864451 3621 5722345 SGTC_2221 6807166 181.081 µM -0.66029256094988 0.262434676908885 no 2464 0.254533051515782 3565 674925 SGTC_519 k048-0011 62.8 µM -0.662109101433887 0.261852934765124 no 2465 0.253950651654872 3602 6836379 SGTC_3232 9132874 49.47 µM -0.662563131115182 0.261707636377415 no 2466 0.25380519480623 3585 3784940 SGTC_3082 9117008 49.47 µM -0.663018811198635 0.261561851433896 no 2467 0.253659253209666 3616 41448529 SGTC_1708 st033234 31.827 µM -0.663363099821655 0.261451731421518 no 2468 0.2535490164219 3663 674664 SGTC_1657 st012939 43.4 µM -0.664340644985677 0.261139195405919 no 2469 0.253236156272184 3639 24207257 SGTC_454 lyso-paf C-16 6.67 µM -0.664715327236828 0.261019454731141 no 2470 0.25311629427256 3561 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3111 9122088 49.47 µM -0.664948531886845 0.260944941618066 no 2471 0.253041706460804 3540 16876704 SGTC_1146 3579-1023 7 µM -0.665111567273997 0.260892855354133 no 2472 0.252989568345601 3642 X1146 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.665996869755013 0.260610113831609 no 2473 0.252706550596659 3655 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1631 benzylvanillin 81.9 µM -0.6665963045611 0.260418760262483 no 2474 0.252515015108378 3628 75506 SGTC_1526 st051518 75 µM -0.667510636507796 0.260127023619066 no 2475 0.25222300892824 3583 673993 SGTC_1260 0700-1617 7.75 µM -0.667685639096562 0.260071204614617 no 2476 0.252167139429247 3619 2853078 SGTC_2131 toluylene red 5.2905 µM -0.66870536844578 0.25974607357462 no 2477 0.251841721154413 3612 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2721 ifenprodil 61.44 µM -0.670534524637561 0.259163390502402 no 2478 0.251258552754302 3631 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2647 atorvastatin 60.16 µM -0.671786407256761 0.258764989461419 no 2479 0.250859841676815 3611 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2470 5664817 21.68 µM -0.673212633611839 0.258311491566557 no 2480 0.250406012465592 3660 2859561 SGTC_2244 6635614 200 µM -0.673237273857439 0.258303660316499 no 2481 0.250398175696422 3538 836499 SGTC_1472 k841-0093 193 µM -0.673317210221535 0.258278255505445 no 2482 0.250372753028506 3691 X1472 SGTC_2536 dehydroabietamide 32.04 µM -0.674451430588228 0.257917925189866 no 2483 0.250012177231014 3653 3983547 SGTC_1407 3909-7909 12.3 µM -0.67489036815799 0.257778549202708 no 2484 0.24987271019895 3647 4411780 SGTC_1621 st003705 32.4 µM -0.675010738576841 0.257740334776228 no 2485 0.249834471190668 3661 24207032 SGTC_2523 spermine 47.74 µM -0.675357604018822 0.257630230615282 no 2486 0.249724297121618 3604 1103 A DNA binding polyamine. SGTC_3224 9130643 49.47 µM -0.676222288944232 0.257355863377627 no 2487 0.249449761611227 3673 17644395 SGTC_1546 5-methoxyflavanone 78.7 µM -0.676839008086148 0.257160269271304 no 2488 0.249254052717362 3670 147795 SGTC_32 0928-0142 34.1 µM -0.677174560094619 0.257053880542489 no 2489 0.249147603362206 3610 2244242 SGTC_11 0438-0307 1.3 µM -0.678230920295375 0.256719104890828 no 2490 0.248812645263697 3639 4011476 SGTC_2088 5278280 127.392 µM -0.679135897252571 0.256432485385504 no 2491 0.248525879609753 3681 791502 SGTC_2939 9044578 71.43 µM -0.679655776840421 0.256267907315518 no 2492 0.248361221817813 3635 2653634 SGTC_1624 st003710 6.25 µM -0.680037163067637 0.256147207055709 no 2493 0.248240465038593 3656 24207033 SGTC_3044 9093193 49.47 µM -0.680351863994819 0.256047633538503 no 2494 0.248140846136486 3620 25236277 SGTC_1798 st045719 60.953 µM -0.680801530236932 0.255905391121025 no 2495 0.247998540834256 3587 3980186 SGTC_292 k038-0015 474 µM -0.680967105462916 0.255853025285022 no 2496 0.247946152425063 3633 46368540 SGTC_1071 trifluoperazine 6.31 µM -0.681635439297562 0.25564171079069 no 2497 0.247734749999725 3701 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1156 4092-0367 4.88 µM -0.682283221657483 0.255436981301602 no 2498 0.247529940153589 3643 1357585 SGTC_245 methotrexate 289.6 µM -0.683614464071642 0.255016515610046 no 2499 0.247109324366366 3640 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_3153 9100258 49.47 µM -0.68393838301044 0.254914262370153 no 2500 0.247007037665688 3603 25236848 SGTC_3340 9146634 11.102 µM -0.684306881283298 0.254797962625582 no 2501 0.246890701311486 3659 4907387 SGTC_1811 st050069 61.5 µM -0.686514365146592 0.254101852614888 no 2502 0.246194404431955 3635 3877702 SGTC_797 k781-0471 270 µM -0.686893490740677 0.253982399252558 no 2503 0.246074924568048 3653 23738129 SGTC_2696 st077691 74.316 µM -0.687341938383407 0.253841142227657 no 2504 0.24593363831136 3644 757133 SGTC_927 2425-1185 123 µM -0.688387341884622 0.253512009600367 no 2505 0.245604446439911 3643 730375 SGTC_1404 3909-7820 48.3 µM -0.688452929815645 0.253491367512631 no 2506 0.245583801050411 3631 23741373 SGTC_2023 5144124 124 µM -0.688525403732717 0.253468559267839 no 2507 0.24556098921421 3648 2830192 SGTC_1391 3442-0225 151 µM -0.689546840243628 0.253147218027502 no 2508 0.245239603721403 3619 5227075 SGTC_322 k048-0136 19.3 µM -0.689742996872863 0.253085532202261 no 2509 0.245177910758069 3660 6823282 SGTC_344 k064-0035 6.43 µM -0.690122022243631 0.252966361628875 no 2510 0.245058727633289 3635 5088750 SGTC_1284 0929-0043 16 µM -0.69168179146591 0.252476260586076 no 2511 0.244568592151551 3645 1239883 SGTC_3297 9117502 71.43 µM -0.69176422330872 0.252450373289703 no 2512 0.244542703805415 3650 7453720 SGTC_57 miconazole 162.5 nM -0.6948641380745 0.251477877284756 no 2513 0.243570224420268 3610 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2362 9071156 126 µM -0.696606498761035 0.250932139427237 no 2514 0.243024543846956 3664 653133 SGTC_3180 9109287 49.47 µM -0.6986524296245 0.250292119088323 no 2515 0.242384634770975 3667 18891271 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.698714536521308 0.250272703981799 no 2516 0.242365223784781 3646 77254 SGTC_2514 salinomycin 42.74 µM -0.699708930292694 0.249961957411206 no 2517 0.242054549142534 3727 23682228 A polyether potassium ionophore. SGTC_3038 9091290 49.47 µM -0.699892648064904 0.249904568298995 no 2518 0.241997174546521 3692 25236843 SGTC_1952 st077036 64.1 µM -0.700567275757378 0.249693890476169 no 2519 0.241786553310726 3677 2937007 SGTC_3280 9140961 49.47 µM -0.701408701206989 0.249431256040244 no 2520 0.241523996681478 3684 4901226 SGTC_615 k087-0205 167 µM -0.703225587104226 0.248864651932454 no 2521 0.240957587937149 3680 9642773 SGTC_39 0986-0283 58.349 µM -0.703657812920345 0.248729961303115 no 2522 0.240822949286977 3709 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_508 roscovitine 141 µM -0.704146831145464 0.248577619784947 no 2523 0.240670669127123 3725 160355 A CDKinase inhibitor. SGTC_1049 3226-0134 66 µM -0.70445938807327 0.248480276458634 no 2524 0.240573366435572 3712 5702385 SGTC_3312 9133330 71.43 µM -0.705018677521115 0.248306140992811 no 2525 0.240399306439813 3708 17617324 SGTC_779 1360-0071 233 µM -0.705141186976856 0.248268006209549 no 2526 0.240361188660277 3732 7566 SGTC_1838 st055369 84.5 µM -0.705237746597306 0.248237951300223 no 2527 0.240331147272585 3661 676036 SGTC_1752 st044819 83.042 µM -0.706772900388181 0.247760383846048 no 2528 0.239853808953579 3660 441209 YML126C ERG13 SGTC_869 0564-0080 44.1 µM -0.707481926027429 0.247539980414348 no 2529 0.239633520342423 3701 6843321 SGTC_778 3456-2434 196 µM -0.707756669596475 0.247454603454501 no 2530 0.239548189401757 3726 5539063 SGTC_3176 9106582 49.47 µM -0.710006869539768 0.246755943191943 no 2531 0.238849938123724 3585 17018027 SGTC_2857 9024691 58.44 µM -0.710052548428127 0.246741771387328 no 2532 0.238835775213342 3736 16478292 SGTC_3213 9129884 49.47 µM -0.710334914558507 0.246654177405328 no 2533 0.238748236734006 3647 17190742 SGTC_3337 9144342 33.5465 µM -0.711789231597034 0.246203291517518 no 2534 0.238297650954978 3710 17682949 SGTC_977 1348-1378 135 µM -0.715814695561569 0.244957574121967 no 2535 0.237052888529321 3700 X977 SGTC_2045 5106652 78.05 µM -0.716008786704943 0.244897596625421 no 2536 0.236992961687492 3679 673349 SGTC_3002 9075603 71.4286 µM -0.716204647957429 0.244837080146939 no 2537 0.2369324967553 3686 20105405 SGTC_3291 9121177 71.43 µM -0.717058272768403 0.244573424348846 no 2538 0.236669070650126 3677 17015612 SGTC_881 0833-0569 170 µM -0.717239303714322 0.244517529680836 no 2539 0.236613225746935 3712 5418700 SGTC_237 nikkomycin 200 µM -0.718971131925452 0.243983162646594 no 2540 0.236079353403425 3729 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2275 7947463 200 µM -0.719227610076798 0.24390407821314 no 2541 0.236000345096821 3652 1225414 SGTC_3142 9086498 49.47 µM -0.723728125336492 0.242518608498907 no 2542 0.234616331339052 3681 25236367 SGTC_1660 st012960 28.1 µM -0.725339777005178 0.242023505024112 no 2543 0.234121804460064 3698 24207266 SGTC_2409 alverine citrate 63.97 µM -0.725829663423373 0.241873119385062 no 2544 0.233971599849716 3858 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2927 9011802 47.9 µM -0.728839052186804 0.240950408660786 no 2545 0.233050060089421 3718 43912568 SGTC_1085 doxorubicin 7.67 µM -0.72921731940244 0.240834563494345 no 2546 0.232934369270141 3729 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.730437371315657 0.24046112648797 no 2547 0.232561440980036 3737 23847180 SGTC_839 0122-0028 230 µM -0.731271269726934 0.24020606600406 no 2548 0.232306737761036 3752 759448 SGTC_1419 3993-2473 62.6 µM -0.73289198223548 0.239710768518569 no 2549 0.231812156823051 3787 704026 SGTC_164 4100-3994 89.624 µM -0.733433402354292 0.239545432215921 no 2550 0.231647066418262 3737 4615967 SGTC_3015 9080845 49.47 µM -0.734094970971688 0.239343490078866 no 2551 0.231445429181411 3786 5296973 SGTC_2298 7976326 193.81 µM -0.734948949292578 0.239082952920436 no 2552 0.23118529280818 3622 2235818 SGTC_3012 9080433 71.4286 µM -0.736080230080173 0.23873805339083 no 2553 0.230840936708067 3736 17688859 SGTC_3168 9103419 49.47 µM -0.736417432243101 0.238635301478997 no 2554 0.230738349532093 3671 16649256 SGTC_1014 4130-3005 69.3 µM -0.737383351239306 0.238341101592968 no 2555 0.230444628533852 3746 743608 SGTC_713 1488-1073 324 µM -0.738586754945365 0.237974846624328 no 2556 0.2300789847057 3713 3312542 SGTC_2730 imipramine 71.33 µM -0.738828454132217 0.237901322893247 no 2557 0.230005585660555 3739 3696 A tricyclic antidepressant. SGTC_2710 st078562 53.7235 µM -0.740069810192393 0.237523904675686 no 2558 0.229628818047595 3714 17250908 SGTC_2623 humulene 100 µM -0.740578840898495 0.237369235550272 no 2559 0.229474420655097 3683 6187145 An anti-inflammatory. SGTC_3096 9117468 49.47 µM -0.741095696022674 0.237212245573315 no 2560 0.229317709529872 3693 41316311 SGTC_2588 indole-3-carbinol 100 µM -0.741558159489247 0.237071824921749 no 2561 0.229177540896966 3755 3712 Induces cell cycle arrest. SGTC_1527 coumarin 137 µM -0.741964972432275 0.236948339556918 no 2562 0.229054279185101 3798 323 A hepatotoxic, DNA x-linker. SGTC_2373 9071805 200 µM -0.742558311615296 0.23676829879911 no 2563 0.228874567916227 3717 10149009 SGTC_1132 3456-3614 2.5 µM -0.743146246239577 0.23658997221577 no 2564 0.228696571669422 3826 3125502 SGTC_2517 totarol 10 µM -0.743449638127795 0.236497979267803 no 2565 0.228604750683166 3728 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1204 4049-0315 18.3 µM -0.744466081000409 0.236189922121148 no 2566 0.22829727708296 3829 588402 SGTC_2644 guaiazulene 100 µM -0.746109657314938 0.235692265255387 no 2567 0.227800588001862 3777 3515 A coloring agent. SGTC_2220 6782180 200 µM -0.747185150509187 0.235366930992793 no 2568 0.227475903192864 3669 833803 SGTC_2959 9079155 11 µM -0.747477661777431 0.235278489889797 no 2569 0.227387640939035 3743 16189457 SGTC_1920 st075728 45.7 µM -0.747484174107466 0.235276521088473 no 2570 0.227385676130282 3735 3400306 SGTC_161 4065-0411 162.148 µM -0.748831349479241 0.234869439948305 no 2571 0.226979430987431 3794 1906281 YLR208W SEC13 SGTC_3211 9128781 49.47 µM -0.749141432490051 0.234775796120406 no 2572 0.226885982420697 3803 17194361 SGTC_3028 9087778 49.47 µM -0.749519168397567 0.234661749280161 no 2573 0.226772174876987 3727 17217395 SGTC_2759 disulfiram 3.38 µM -0.751037191883408 0.234203733440112 no 2574 0.226315136583563 3714 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1772 st048439 82.2 µM -0.751506905943237 0.234062112326767 no 2575 0.226173823095328 3780 2927068 YDL195W SEC31 SGTC_2446 5162541 200 µM -0.752233429364778 0.233843155365625 no 2576 0.22595534673803 3732 1549321 SGTC_1237 0330-0133 46.1 µM -0.752359777692266 0.233805088560186 no 2577 0.225917364107144 3700 X1237 YHR072W ERG7 SGTC_2891 9063876 19.48 µM -0.752403315696194 0.233791972025696 no 2578 0.22590427661886 3757 6472478 SGTC_756 0508-1999 28.3 µM -0.752740839735387 0.233690301235524 no 2579 0.225802831714829 3756 6753853 SGTC_2962 9082311 13.18 µM -0.752956114771525 0.233625467746103 no 2580 0.225738142952369 3757 16459453 SGTC_464 bw-b 70c 158 µM -0.75458644456511 0.233134791989679 no 2581 0.225248579809326 3820 5353454 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.756432529637747 0.232579872365884 no 2582 0.224694955335321 3762 4330530 SGTC_1810 st050138 53 µM -0.757308547210873 0.232316805043964 no 2583 0.224432515699042 3729 3444541 SGTC_1953 st076800 12.1 µM -0.75969037403238 0.231602382111 no 2584 0.223719841982709 3802 297591 SGTC_1455 4262-0120 131 µM -0.759983501583474 0.23151454394513 no 2585 0.223632223389952 3880 1529587 SGTC_2218 6965428 192.983 µM -0.766691717035325 0.229509453375314 no 2586 0.221632414754877 3710 675684 SGTC_1042 0350-0096 82 µM -0.766994943679996 0.229419049155803 no 2587 0.221542260905659 3784 3122515 SGTC_2866 9034245 58.44 µM -0.768044242157764 0.229106364600685 no 2588 0.221230450481382 3768 6462273 SGTC_629 3448-6466 76.7 µM -0.768707975769248 0.22890869951902 no 2589 0.221033344528052 3783 573744 SGTC_314 1671-0008 2.74 µM -0.769773776737177 0.228591495940867 no 2590 0.220717048819473 3724 3913060 SGTC_1026 k007-1105 30.6 µM -0.770898666053201 0.228256974444408 no 2591 0.220383498938467 3781 7066794 SGTC_1393 3470-5649 58.2 µM -0.771229893861263 0.228158525824806 no 2592 0.220285339038281 3749 4108395 SGTC_2754 granisetron 64.02 µM -0.771348012230243 0.228123424070086 no 2593 0.220250340531729 3760 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1019 4262-0212 3.4 µM -0.771386715377898 0.228111923146187 no 2594 0.220238873471547 3830 4677213 SGTC_323 4013-0906 34.3 µM -0.771551522390786 0.228062953185209 no 2595 0.22019004789251 3822 2910086 SGTC_2138 5575593 77.673 µM -0.772444221115201 0.227797803760542 no 2596 0.219925685662608 3773 762213 SGTC_2702 st077768 96.8 µM -0.773353539345779 0.227527896458906 no 2597 0.219656589113197 3759 6484119 SGTC_1064 honokiol 6.76 µM -0.775071289865139 0.227018518983428 no 2598 0.219148767687105 3802 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_477 mead ethanolamide 10 µM -0.778086309012849 0.226126009425877 no 2599 0.218259066678815 3665 16061185 SGTC_2933 9026794 32.47 µM -0.77876666767226 0.225924883417468 no 2600 0.218058588048368 3806 17586027 SGTC_2408 sulbentine 18.36 µM -0.778818622070647 0.22590952893984 no 2601 0.218043283212403 3799 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_224 benfluorex 43.875 µM -0.780159316563363 0.225513507453643 no 2602 0.217648552833177 3774 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2926 9010726 65.15 µM -0.780981757384036 0.225270765084198 no 2603 0.217406612097157 3821 2994293 SGTC_3162 9099653 49.47 µM -0.782300985349037 0.224881705842098 no 2604 0.217018853958475 3750 25237511 SGTC_2305 7443522 69.23 µM -0.783011664715304 0.224672274280661 no 2605 0.216810131094254 3746 5415886 SGTC_1917 st066507 28.5 µM -0.785589335442801 0.223913584191111 no 2606 0.216054057155214 3785 3156428 SGTC_268 camptothecin 39.6153 µM -0.786793705317808 0.223559599645337 no 2607 0.215701319471805 3800 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_532 1548-0774 215 µM -0.787664840431721 0.223303756887838 no 2608 0.215446388303476 3940 5932993 SGTC_3065 9113888 49.47 µM -0.787848112017953 0.223249953271402 no 2609 0.215392777507578 3844 16648368 SGTC_3021 9087658 49.47 µM -0.788886657097822 0.222945203737867 no 2610 0.215089127443223 3756 25237042 SGTC_1159 4092-0538 61.2 µM -0.79148340209323 0.222184255594786 no 2611 0.21433097901231 3842 717301 SGTC_886 0866-0150 153 µM -0.792507440252976 0.221884580241235 no 2612 0.214032427601891 3851 271463 SGTC_2738 aclarubicin 5.55 µM -0.793006393575386 0.221738649816556 no 2613 0.213887048874929 3764 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2645 abamectin 100 µM -0.793903951660885 0.221476276306916 no 2614 0.213625674507816 3783 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1474 0330-0125 5.35 µM -0.795031141919146 0.221147028429194 no 2615 0.213297693591757 3821 X1474 SGTC_1854 st056233 32.9 µM -0.795748894043532 0.22093752184921 no 2616 0.213089000837016 3734 5393174 SGTC_351 caspofungin 25 nM -0.796394939829005 0.220749043018775 no 2617 0.212901259229642 3839 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_350 k064-0020 19.8 µM -0.796991168196003 0.220575179767814 no 2618 0.212728080304395 3777 2790705 SGTC_1924 st058459 75.1 µM -0.800604058541413 0.219523321943403 no 2619 0.211680450212244 3764 688683 SGTC_2780 5215298 71.43 µM -0.801329293178456 0.219312524714347 no 2620 0.211470518375558 3847 2834131 SGTC_1511 0906-3109 28.5 µM -0.80319627598244 0.21877040165605 no 2621 0.210930648812619 3870 2882180 SGTC_1104 tacrolimus 29.8 µM -0.803786090652832 0.218599295306699 no 2622 0.210760262073312 3869 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_3236 9132701 49.47 µM -0.80466319382273 0.218344988549658 no 2623 0.210507032256591 3843 24282524 SGTC_2717 st081029 62.2815 µM -0.80466395882266 0.218344766820457 no 2624 0.210506811470245 3826 5292846 SGTC_792 4534-1957 155 µM -0.804992872137098 0.218249445905999 no 2625 0.210411896512398 3811 1717904 SGTC_1951 sophoraflavanone G 9.2 µM -0.807133941743207 0.21762953831193 no 2626 0.209794659497503 3846 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1503 4585-0012 61.3 µM -0.807682971386189 0.21747074063922 no 2627 0.209636554446935 3868 2922052 SGTC_945 3381-0768 11.3 µM -0.809712034045152 0.216884448802134 no 2628 0.20905284998113 3893 1126236 YIL048W NEO1 SGTC_3130 9127414 49.47 µM -0.81031742605542 0.21670969965899 no 2629 0.208878881223516 3842 1494646 SGTC_2565 isoliquiritigenin 100 µM -0.813167331848714 0.215888156158319 no 2630 0.208061063300187 3930 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1875 nocodazole 6 µM -0.813263835970041 0.215860368503697 no 2631 0.208033403298446 3815 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2522 biochanin a 4.94 µM -0.813906069005561 0.215675495010005 no 2632 0.207849381826707 3836 5280373 A possible chelator. SGTC_402 epigallocatechin gallate 10 µM -0.814021259881077 0.215642345823827 no 2633 0.207816385917755 3819 65064 An antioxidant. SGTC_2178 5812956 200 µM -0.815219302953901 0.215297752785908 no 2634 0.207473395305525 3836 5403383 SGTC_2476 5806916 10.51 µM -0.816707720294395 0.214870084836678 no 2635 0.207047739157266 3763 2870194 SGTC_1515 3460-0031 42.1 µM -0.817316998288475 0.214695163027519 no 2636 0.206873647573555 3801 2876596 SGTC_2544 sphondin 68.51 µM -0.818626418994358 0.21431951259077 no 2637 0.206499794565253 3823 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_166 k072-0058 166.424 µM -0.818969835996119 0.214221055435461 no 2638 0.206401811786552 3830 5846229 SGTC_133 0724-0033 378.92 µM -0.819016942532085 0.214207552112699 no 2639 0.206388373630325 3717 280309 SGTC_2614 arthonioic acid 13.39 µM -0.821934237867338 0.213372260333251 no 2640 0.205557162803847 3792 6710684 SGTC_514 4466-0038 2.65 nM -0.822395011946144 0.213240503494417 no 2641 0.20542605866192 3766 5722064 SGTC_2341 7987486 176.74 µM -0.825863333966276 0.212250271857246 no 2642 0.204440810995616 3893 1258686 SGTC_1406 3909-7906 11.9 µM -0.825895746456233 0.212241030545618 no 2643 0.204431616851242 3875 X1406 SGTC_2724 maprotiline 69.64 µM -0.826861926475534 0.211965665410811 no 2644 0.204157662734282 3807 4011 A tricyclic antidepressant. SGTC_644 1498-1197 63.3 µM -0.830290889021901 0.210990085797687 no 2645 0.203187169034095 3942 6741615 SGTC_174 3553-0389 74.3 µM -0.830714621353369 0.21086971204608 no 2646 0.203067432232551 3894 738071 SGTC_1886 st057356 49.9 µM -0.832706149272106 0.210304499086026 no 2647 0.202505237800364 3849 24207747 SGTC_38 0929-0051 58.268 µM -0.833918680114494 0.209960808400602 no 2648 0.202163405004222 3902 1379719 SGTC_1719 st032227 49.2 µM -0.835554467961999 0.209497669326276 no 2649 0.201702796389644 3882 3125804 SGTC_1145 3546-0597 10.2 µM -0.835824555594848 0.209421257519269 no 2650 0.201626805044183 3862 875334 SGTC_2040 5100729 123 µM -0.837742940024828 0.208878990122949 no 2651 0.201087545724058 3893 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2994 9053520 71.4286 µM -0.838007027098855 0.208804405781871 no 2652 0.201013378443023 3941 4647384 SGTC_2352 9027995 87.8 µM -0.838092580339584 0.208780246919668 no 2653 0.200989354844701 3848 2997347 SGTC_2456 5770359 74.46 µM -0.841824226330217 0.207728093651633 no 2654 0.199943174612475 3916 3118787 SGTC_3330 9141424 71.43 µM -0.841845738630186 0.207722037262845 no 2655 0.199937153071148 3965 27261020 SGTC_135 0933-0004 26.348 µM -0.842346946455011 0.207580961030436 no 2656 0.199796890079277 3888 21230617 YGL099W LSG1 SGTC_785 1270-0111 65.3 µM -0.842560450118229 0.20752088281515 no 2657 0.199737159067856 3838 6741994 SGTC_1214 0358-0031 63.7 µM -0.843841917373276 0.207160504225212 no 2658 0.199378874224342 4057 4301366 SGTC_596 1155-0152 116 µM -0.843860521467324 0.207155275046029 no 2659 0.199373675565418 3884 280313 SGTC_1411 3909-8223 150 µM -0.845193303886178 0.206780864016311 no 2660 0.199001460182657 3894 X1411 SGTC_505 gw-5074 63.9 µM -0.846099230826758 0.206526595944983 no 2661 0.198748694901521 3945 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_560 2332-1943 155 µM -0.846283732403077 0.206474834280633 no 2662 0.198697240322292 3878 21177716 SGTC_2629 bisabolol 100 µM -0.847813572532465 0.206045935882405 no 2663 0.198270901559637 3930 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1795 st049545 62.3 µM -0.84899200026207 0.205715918245792 no 2664 0.197942871843243 3841 5291882 SGTC_84 0443-0269 128.823 µM -0.850318817728434 0.205344719883711 no 2665 0.197573928621847 3792 6150058 SGTC_1372 2752-0194 270 µM -0.852669477883718 0.204688062827221 no 2666 0.196921310764974 3865 823334 SGTC_2720 fluspirilene 36.88 µM -0.853774194231053 0.204379892215222 no 2667 0.196615057756942 3902 3396 An atypical antipsychotic. SGTC_112 phenothiazine 287.218 µM -0.854274989688291 0.20424028182742 no 2668 0.196476320735254 3831 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_414 piperonyl butoxide 100 µM -0.854885628896467 0.204070126361136 no 2669 0.196307233629489 3897 5794 A potent inhibitor of cytochrome P450. SGTC_1852 st056254 31.4 µM -0.855252744931735 0.203967869625348 no 2670 0.196205621005574 3859 442583 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.856877790116023 0.203515595319149 no 2671 0.195756214216612 3959 1273210 SGTC_2303 7774051 200 µM -0.857701683969551 0.203286522074036 no 2672 0.195528604972791 3875 2953184 SGTC_2625 euphol 100 µM -0.858691042159059 0.203011646995777 no 2673 0.195255496952204 3946 6708538 A triterpene alcohol. SGTC_1732 st034308 51.822 µM -0.859151776033768 0.202883716297378 no 2674 0.195128392517506 3785 830119 SGTC_1628 st004252 77.7 µM -0.859603075123374 0.20275845202749 no 2675 0.195003939661903 3946 692968 SGTC_3215 9129942 49.47 µM -0.861092651314392 0.202345327768849 no 2676 0.194593508121874 3883 17682944 SGTC_1530 rhein 70.4 µM -0.863314497772586 0.201730049431779 no 2677 0.193982287621104 3975 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1134 3477-0009 42.5 µM -0.866387064763139 0.200881036369533 no 2678 0.193138967543056 4029 3973534 SGTC_73 0327-0325 16.231 µM -0.868282257640562 0.200358426613319 no 2679 0.192619916297626 3857 53298 SGTC_1509 1326-1131 80 µM -0.869027023777799 0.200153277058122 no 2680 0.192416174951532 3820 768313 SGTC_2175 5807670 165.306 µM -0.869786094563656 0.199944317179874 no 2681 0.192208656011366 3921 241186 SGTC_2402 5553605 200 µM -0.870320891447885 0.199797175068644 no 2682 0.192062532542321 3994 6758546 SGTC_1012 4112-3522 18 µM -0.872100987918037 0.199307875086355 no 2683 0.191576643629759 3942 3112398 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.872568282981819 0.199179548088142 no 2684 0.191449217287117 3880 140250 A respiratory chain inhibitor. SGTC_1212 0520-0165 585 µM -0.873651664335298 0.198882225055656 no 2685 0.191153990670285 4057 5403258 SGTC_1081 sertraline 6 µM -0.874084897387611 0.198763403552288 no 2686 0.191036010756353 3930 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2176 5809774 33.9695 µM -0.875139171869381 0.198474429779498 no 2687 0.190749092755195 3915 2870539 SGTC_3031 9088762 49.47 µM -0.876439882373296 0.198118258031035 no 2688 0.190395472455383 3912 205253 SGTC_2515 chrysin 20.77 µM -0.877527616866603 0.197820701718139 no 2689 0.190100062647197 3959 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_26 0302-0163 425.158 µM -0.880671718529181 0.196962133246607 no 2690 0.189247764205822 3993 3100915 SGTC_3024 9090631 49.47 µM -0.881213589112228 0.19681439136592 no 2691 0.189101112756145 3894 25236383 SGTC_2650 prasterone 100 µM -0.88138217865434 0.196768438848528 no 2692 0.189055500087354 3908 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_398 bronopol 33.3 µM -0.882854876764982 0.196367301295918 no 2693 0.188657343109161 3846 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2651 TUB2.036 5 µM -0.883128792466547 0.196292746094204 no 2694 0.188583344627372 3960 15992207 YFL037W TUB2 SGTC_3308 9128332 17.569 µM -0.885432510024652 0.195666392622 no 2695 0.187961702412389 3980 17332805 YDL196W YDL196W SGTC_3287 9117173 37.0625 µM -0.885780616729489 0.195571852174798 no 2696 0.187867878380282 3910 2789709 SGTC_3166 9102297 49.47 µM -0.886936176489118 0.195258218764245 no 2697 0.187556631633016 3981 25237072 SGTC_2715 st079500 56.4 µM -0.887484797072077 0.195109423310917 no 2698 0.187408973847392 3898 28246688 SGTC_3270 9137563 49.47 µM -0.887530087677978 0.195097142790581 no 2699 0.187396787376753 3936 17015724 SGTC_796 1234-0020 70.7 µM -0.888436959012232 0.194851344080977 no 2700 0.1871528760676 3879 46495034 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.889133732091115 0.194662618476685 no 2701 0.186965606043072 3933 66535 A nucleotide analog. SGTC_1200 1643-0193 18.4 µM -0.889511551551939 0.194560330092531 no 2702 0.186864108910296 3937 5403974 SGTC_2598 perillyl alcohol 100 µM -0.892241355557651 0.193822253074419 no 2703 0.186131790015442 3989 10819 An apoptosis inducer. SGTC_2117 5521686 200 µM -0.893403806936983 0.193508471449598 no 2704 0.185820482354413 3919 803312 SGTC_1933 st074711 15.9 µM -0.894120057963845 0.193315287488776 no 2705 0.185628829254179 3934 17250958 SGTC_2281 7943571 200 µM -0.895209427110809 0.193021693528819 no 2706 0.185337573139409 4065 1244024 SGTC_1799 st045822 46.1415 µM -0.899320627952212 0.191916145892276 no 2707 0.18424095149003 3910 3674992 SGTC_1401 3807-4679 7.6 µM -0.900175572076672 0.191686729668966 no 2708 0.18401341189791 3903 3291456 SGTC_104 0074-0074 590.992 µM -0.900320348530146 0.191647896903167 no 2709 0.183974897616269 3764 3943124 SGTC_1421 4029-0249 71.4 µM -0.900794745607555 0.191520685179165 no 2710 0.183848730896602 4035 2894095 SGTC_2480 5767542 37.17 µM -0.900951942418032 0.191478543556383 no 2711 0.183806936024049 3940 2867358 SGTC_978 1416-0512 87.4 µM -0.906634821071239 0.18995888397112 no 2712 0.18229997072724 4045 6814003 SGTC_2173 5763948 167 µM -0.906748512446065 0.189928557582517 no 2713 0.182269901445325 3974 2867177 SGTC_2966 9084041 48.03 µM -0.908335678161801 0.18950550296482 no 2714 0.181850448959051 3894 17741380 SGTC_1705 st027868 56.3335 µM -0.908376314504684 0.189494679078852 no 2715 0.181839717613283 3927 292948 SGTC_123 0083-0120 66.675 µM -0.90959799417661 0.189169450448519 no 2716 0.18151727840929 3954 16001701 SGTC_936 3005-4620 401 µM -0.911684247693483 0.188614855120458 no 2717 0.180967479291583 4000 777207 SGTC_2983 9022671 12.99 µM -0.912820794536896 0.188313145539888 no 2718 0.180668399922584 4004 6405161 SGTC_1232 0279-0259 161 µM -0.91287476316006 0.18829882634956 no 2719 0.180654205930842 4002 1560000 SGTC_1606 st000094 49.2 µM -0.913775529987278 0.188059930148357 no 2720 0.180417403426126 3997 1242210 SGTC_1470 k295-0292 231 µM -0.918201979745539 0.186888693208436 no 2721 0.179256566202083 4068 5045612 SGTC_517 1365-0151 113 µM -0.919629455700161 0.18651194823484 no 2722 0.178883214266275 4059 768657 SGTC_1062 mesoridazine 14.2 µM -0.924103882010499 0.185334091154621 no 2723 0.177716116169552 4008 4078 A neuroleptic. SGTC_725 1497-0963 19 µM -0.924685547923702 0.185181312162961 no 2724 0.177564749537489 4085 3549977 SGTC_3302 9125395 16.351 µM -0.924863216525177 0.18513466174807 no 2725 0.177518531152467 3951 17599668 SGTC_2897 9048598 12.99 µM -0.92567387813591 0.184921899116584 no 2726 0.177307743500456 3984 6467404 SGTC_2684 capsaicin 100 µM -0.925890034207517 0.184865193426964 no 2727 0.177251565453791 4029 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3103 9120822 49.47 µM -0.926406601813708 0.18472972251903 no 2728 0.177117357259274 4022 17141819 SGTC_2626 ethyl orsellinate 100 µM -0.926674909384463 0.184659382670678 no 2729 0.177047674247468 4000 75653 A natural product. SGTC_605 1315-0399 119 µM -0.927565065149683 0.184426137618418 no 2730 0.176816613144333 4076 24020461 SGTC_3091 9116372 49.47 µM -0.930161530140595 0.183746840646183 no 2731 0.176143728375111 4087 17169793 SGTC_433 pimozide 108 µM -0.931862554024594 0.183302658560043 no 2732 0.175703780887728 3925 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2827 7993847 71.43 µM -0.932393015363702 0.183164278218474 no 2733 0.175566726554402 4083 2985692 SGTC_1842 st055362 61.2 µM -0.93566863837706 0.1823112174739 no 2734 0.174721911291182 3968 676032 SGTC_1173 0443-0020 122 µM -0.936218531929245 0.182168254083939 no 2735 0.174580341759559 4007 5331295 SGTC_1974 st069448 26.9 µM -0.939029521514164 0.181438537609439 no 2736 0.17385779373696 3998 6323587 YNR016C ACC1 SGTC_513 4245-1575 41.7 µM -0.940809232621607 0.180977482394719 no 2737 0.1734013143408 3931 719745 SGTC_981 1488-1094 54.9 µM -0.941963797720515 0.180678771631916 no 2738 0.173105587501126 3989 3449522 SGTC_1247 0448-0043 5.84 µM -0.942288364836313 0.180594854854932 no 2739 0.173022511735283 4055 3089013 YGL099W LSG1 SGTC_1851 st056236 18.9 µM -0.94539506685678 0.17979285465827 no 2740 0.172228609892795 4015 5393171 SGTC_2518 prenyletin 46.28 µM -0.947621200388126 0.179219552851709 no 2741 0.17166116471655 3982 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1879 gemcitabine 100 µM -0.948068569620099 0.179104479617143 no 2742 0.171547273838614 3991 60750 A nucleoside analog which inhibits DNA replication. SGTC_3030 9087619 49.47 µM -0.949472127602699 0.178743755305988 no 2743 0.171190270697918 4062 25236973 SGTC_960 1222-0186 7.7 µM -0.949723310093231 0.178679247917686 no 2744 0.171126431123829 4073 3126296 SGTC_467 ro 31-8220 72.8 µM -0.950066816806223 0.178591054033817 no 2745 0.171039151432503 3973 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2921 7974240 10.71 µM -0.953218962812174 0.177783034442661 no 2746 0.170239570221423 4131 2979074 YDR527W RBA50 SGTC_2048 5246248 200 µM -0.956333090966175 0.176987028766084 no 2747 0.169451988368118 4049 677046 SGTC_93 0109-0045 59.227 µM -0.966291143583812 0.174456784579228 no 2748 0.166949258228097 4151 88733 SGTC_1326 1431-2094 10.8 µM -0.967195661894234 0.17422809912392 no 2749 0.166723115212949 4043 616278 SGTC_1379 2144-0755 36.5 µM -0.968204881629003 0.173973167422563 no 2750 0.166471028701612 4126 5392327 SGTC_1496 4469-0713 57.4 µM -0.969776931420797 0.173576536010411 no 2751 0.166078846936551 4039 746691 SGTC_1333 1482-0047 286 µM -0.970260908102355 0.173454543627837 no 2752 0.165958228778066 4059 3811116 SGTC_1840 st055363 71 µM -0.971560929117894 0.173127127301681 no 2753 0.165634513885903 4102 676033 SGTC_696 1560-0013 611 µM -0.972283210972546 0.172945387486216 no 2754 0.165454836911221 4118 1650269 SGTC_2375 9072683 200 µM -0.973354234000298 0.172676121631763 no 2755 0.165188638243217 4091 16798029 SGTC_418 lividomycin a 100 µM -0.977661686596955 0.171595885967768 no 2756 0.164120838492524 4089 72394 An antibiotic. SGTC_1023 4482-3888 16 µM -0.977957598909809 0.171521835039417 no 2757 0.164047647761471 4098 3303168 SGTC_2260 7964312 200 µM -0.979982850605323 0.171015571789066 no 2758 0.163547291996624 4137 231951 SGTC_635 k038-0028 24.7 µM -0.980260221075682 0.170946310469815 no 2759 0.163478842485823 4070 4035102 SGTC_2568 diosmetin 100 µM -0.980297465152342 0.170937011733865 no 2760 0.163469652806166 4127 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_518 1021-0119 62.6 µM -0.981441716123504 0.170651484076855 no 2761 0.163187481482817 4045 1097762 SGTC_993 3909-8757 62.7 µM -0.982252687125617 0.170449305543037 no 2762 0.162987688488944 4008 4288324 YLR208W SEC13 SGTC_3217 9129673 49.47 µM -0.98352585188595 0.170132209720405 no 2763 0.162674349128006 4124 17248312 SGTC_327 1273-0057 3.96 µM -0.983712962574068 0.170085639607112 no 2764 0.162628332249446 3944 3108138 SGTC_1640 st009078 66.4 µM -0.986126086337426 0.169485767737736 no 2765 0.162035622048716 4039 690618 SGTC_324 1315-0088 19.6 µM -0.986285481431069 0.169446192000188 no 2766 0.161996521107903 4032 6787421 SGTC_1587 estradiol valerate 56.1 µM -0.986588042419658 0.169371086338359 no 2767 0.161922317290496 4125 13791 A steroid. SGTC_2406 ethylparaben 405.7 µM -0.987487929313765 0.169147830895854 no 2768 0.161701748735106 4098 8434 A possible steroid mimic. SGTC_443 clozapine 122 µM -0.988795271010654 0.168823825691855 no 2769 0.161381659226967 3983 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1347 1493-0251 600 nM -0.989919446948741 0.168545534501554 no 2770 0.161106746684265 4134 3986378 SGTC_202 3594-0513 34.79 µM -0.990353655737577 0.168438124560901 no 2771 0.161000644591469 4085 708429 SGTC_2896 9052656 71.43 µM -0.991443596336838 0.168168700637563 no 2772 0.160734510602468 3927 6469436 SGTC_3320 9137005 35.139 µM -0.994803111834261 0.167340002868362 no 2773 0.159916016241351 4096 4908713 SGTC_376 3970-0862 59.1 µM -0.997204103264426 0.166749361302098 no 2774 0.159332724836253 4130 3135186 SGTC_1365 1672-3266 55.4 µM -0.997705821973619 0.166626109099059 no 2775 0.159211014626666 4131 6415873 SGTC_82 0054-0107 293.755 µM -1.00186152738512 0.165607479791465 no 2776 0.158205238049789 4035 3104697 SGTC_1603 st002045 67.8 µM -1.0020412452344 0.165563519130679 no 2777 0.158161836450363 4088 5887985 SGTC_1742 st038235 28.8875 µM -1.00253187635778 0.165443544616372 no 2778 0.158043389538256 4145 564103 YBR002C RER2 SGTC_2075 5212009 200 µM -1.0033245698635 0.165249825360071 no 2779 0.15785214257316 3999 780898 SGTC_1277 0873-0036 22 µM -1.00347818640718 0.165212301377792 no 2780 0.157815098297929 4171 5965735 SGTC_277 nystatin 15.5 µM -1.00385552480642 0.165120152169531 no 2781 0.157724128252258 4086 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2659 sanguinarine 24.21 µM -1.00416226704109 0.165045267659307 no 2782 0.157650203160742 4032 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_850 0388-0143 75.9 µM -1.00850391349601 0.163987706799147 no 2783 0.15660630495967 4059 67273 SGTC_326 k292-0812 17.5 µM -1.00949466372668 0.163746992180455 no 2784 0.156368729772669 4084 3579357 SGTC_275 trichlorophene 5.69 µM -1.00954634361033 0.163734442231711 no 2785 0.156356343804271 4148 62616 SGTC_478 N-arachidonylglycine 10 µM -1.00975803944816 0.163683040508014 no 2786 0.156305614019438 4048 5283389 SGTC_2610 ononetin 44.17 µM -1.01196726819574 0.163147244362427 no 2787 0.155776851943158 4097 259632 SGTC_627 1391-0720 175 µM -1.01227304882249 0.163073174408597 no 2788 0.155703758709615 4081 997839 SGTC_2603 homopterocarpin 100 µM -1.0143076872572 0.162580875891379 no 2789 0.15521797854025 4110 101795 A weak amylase inhibitor. SGTC_3171 9103192 49.47 µM -1.0153564595623 0.162327494346266 no 2790 0.154967970038226 4157 13018434 SGTC_1007 4101-0031 70 µM -1.01844474220015 0.161582864469475 no 2791 0.154233324222971 4080 1146276 SGTC_3001 9076041 71.4286 µM -1.0198066812767 0.161255189803798 no 2792 0.153910076938649 4097 16004211 SGTC_502 l-744,832 89.3 µM -1.01999309825311 0.161210372707162 no 2793 0.153865867003209 4123 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_535 2293-4129 48.2 µM -1.02030918969307 0.16113439873419 no 2794 0.153790923178621 4120 396118 YIL048W NEO1 SGTC_1073 triclabendazole 3.09 µM -1.02095547814479 0.160979133179087 no 2795 0.15363776638205 4172 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1162 k048-0130 20.1 µM -1.02114919983476 0.160932612143247 no 2796 0.15359187808728 4070 6797406 SGTC_124 0136-0217 7.121 µM -1.02139077060255 0.160874612750469 no 2797 0.153534668142674 4156 3976905 SGTC_1093 fluphenazine 7.97 µM -1.0217020136357 0.16079990567031 no 2798 0.153460978886155 4118 6602611 An atypical antipsychotic. SGTC_2932 9016711 44.54 µM -1.0232439614374 0.16043012897748 no 2799 0.153096256065843 4140 7117328 SGTC_1902 st060212 70.5 µM -1.02325753837804 0.160426875541624 no 2800 0.153093047213874 4111 688944 SGTC_594 1487-1584 10.8 µM -1.02410379982523 0.160224171399994 no 2801 0.152893124919451 4082 5013332 SGTC_1231 0242-0792 125 µM -1.0257054503224 0.159840988164149 no 2802 0.152515222253791 4107 3707635 SGTC_465 cgp-37157 41 µM -1.0276262956254 0.159382231119637 no 2803 0.15206282498917 4056 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_715 0868-0130 184 µM -1.02763825927004 0.159379376536721 no 2804 0.15206001010854 4170 2876258 SGTC_1486 3970-0793 4.53 µM -1.02811780554546 0.159264982061521 no 2805 0.151947207976504 4130 2844330 SGTC_1497 4476-2978 41.3 µM -1.03163965150469 0.158426503141767 no 2806 0.151120478975762 4166 1528379 SGTC_1914 st062367 72.6 µM -1.03338363788142 0.158012369873809 no 2807 0.150712200238835 4116 978205 SGTC_966 1300-0360 30.2 µM -1.03489955838207 0.157652971840692 no 2808 0.150357910455387 4105 70588 SGTC_1055 3448-0672 86 µM -1.0350030022413 0.157628466713826 no 2809 0.150333754560786 4145 748378 SGTC_2794 7785382 27.27 µM -1.03576254171233 0.157448613774753 no 2810 0.15015646842446 4099 2205081 SGTC_879 0831-1030 162 µM -1.04051671341452 0.156325928797029 no 2811 0.149049951603282 4155 1549252 SGTC_2981 9013952 38.96 µM -1.04212995251984 0.155946167831723 no 2812 0.148675716717325 4100 2996344 SGTC_1177 0983-0204 23.6 µM -1.04318140613976 0.155698980336515 no 2813 0.148432141712368 4158 766818 SGTC_1185 1319-0113 81.3 µM -1.0434360020659 0.155639165953444 no 2814 0.148373203324433 4198 4672763 SGTC_3216 9129716 49.47 µM -1.045041104228 0.155262414683728 no 2815 0.14800198621781 4089 8056934 SGTC_1620 st003704 16.5 µM -1.04612965678872 0.155007251308065 no 2816 0.147750587236462 4104 2834414 SGTC_2744 captopril 92.04 µM -1.04640366614735 0.154943065490098 no 2817 0.147687350414021 4171 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1109 tnp00067 928.257 nM -1.04735484921341 0.154720390140105 no 2818 0.147467973806299 4127 676295 SGTC_1463 k081-0032 34.1 µM -1.04790229930885 0.154592326035962 no 2819 0.147341811406939 3802 977755 SGTC_542 3381-0244 89.3 µM -1.04842105371557 0.154471039329021 no 2820 0.147222328827232 4157 1112843 SGTC_99 0109-0120 622.8 µM -1.048979920836 0.154340444527017 no 2821 0.147093679945347 4115 759414 SGTC_441 propafenone 146 µM -1.05360921932431 0.153261488154167 no 2822 0.146030933263069 4127 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2452 5863136 48.41 µM -1.05629047127007 0.15263885654315 no 2823 0.145417763999597 4102 2184096 SGTC_1040 k898-0338 155 µM -1.05686098214732 0.152506591178619 no 2824 0.145287518963344 4168 20969351 SGTC_438 sphingosine 6.67 µM -1.05776807567236 0.152296450236405 no 2825 0.145080595284545 4090 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2077 5212015 200 µM -1.05788380001343 0.152269654901338 no 2826 0.145054210840322 4002 780900 SGTC_3048 9093155 49.47 µM -1.05807738735485 0.152224837813883 no 2827 0.145010081327388 4124 25236002 SGTC_3101 9120531 49.47 µM -1.06125008439487 0.151491579927601 no 2828 0.144288131815593 4186 24824904 SGTC_2120 5538279 151.968 µM -1.06201674100206 0.151314746962501 no 2829 0.144114042633179 4119 2058197 SGTC_1755 st041960 45.185 µM -1.06249544042424 0.151204402331041 no 2830 0.144005413421417 4206 2257073 SGTC_1722 st034304 3.6505 µM -1.06300124773052 0.151087867259354 no 2831 0.143890692750413 4145 4036148 YLR033W RSC58 SGTC_2216 7189485 200 µM -1.06372987134729 0.150920101677003 no 2832 0.143725544160921 4160 731273 SGTC_795 0685-0265 78 µM -1.06408834146967 0.150837609457775 no 2833 0.143644340893133 4171 302754 SGTC_2110 5483698 200 µM -1.06447198463253 0.150749357601503 no 2834 0.143557469551521 4123 2848765 YHR062C RPP1 SGTC_3106 9121286 49.47 µM -1.06474988581641 0.150685451715119 no 2835 0.143494564350819 4152 15943471 SGTC_2283 7944793 200 µM -1.06528978395262 0.150561348839429 no 2836 0.143372407200989 4186 2970533 SGTC_1348 1493-0373 93.8 µM -1.06558552595129 0.150493397415561 no 2837 0.143305522502614 4162 3010129 SGTC_598 3937-0236 20.2 µM -1.06609838300529 0.150375608796003 no 2838 0.14318958525319 4223 1379313 SGTC_405 ebelactone b 50 µM -1.0675843041772 0.150034682032198 no 2839 0.142854033423295 4123 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2099 5377090 177.372 µM -1.06826460631373 0.149878766993128 no 2840 0.142700584591767 4167 2243829 SGTC_952 1185-0122 232 µM -1.06826534825749 0.149878597009765 no 2841 0.142700417299918 4103 678600 SGTC_1691 st019933 84.6 µM -1.06930774049752 0.149639906243878 no 2842 0.142465511938428 4152 6176082 SGTC_2200 6600604 21.907 µM -1.07190703853259 0.1490458148581 no 2843 0.141880894245195 4172 2904777 SGTC_1072 oxiconazole 14.9 nM -1.07655321154187 0.147987823103206 no 2844 0.140839958257579 4159 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_526 4469-0568 170 µM -1.07661864140667 0.147972959887079 no 2845 0.140825336339507 4117 2901964 SGTC_3240 9133527 49.47 µM -1.0775625317203 0.147758654521466 no 2846 0.140614515351962 4114 17617455 SGTC_2913 7966556 36.57 µM -1.08115777827263 0.146944276833665 no 2847 0.139813467862213 4048 2976516 SGTC_507 nimesulide 162 µM -1.08188958900235 0.146778880083838 no 2848 0.139650795741432 4244 4495 A COX2 inhibitor. SGTC_716 1683-5115 658 µM -1.08438843695988 0.146215056405212 no 2849 0.13909630420747 4119 723597 SGTC_1269 0831-0796 3.05 µM -1.08539766161138 0.145987754478937 no 2850 0.138872783814557 4209 927758 SGTC_3003 9075612 71.4286 µM -1.08658985827314 0.145719548850352 no 2851 0.138609054547649 4202 6501993 SGTC_2582 agaric acid 100 µM -1.08733292444111 0.145552550703034 no 2852 0.138444851454636 3883 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2507 purpurin 79.67 µM -1.08764842145178 0.145481684223484 no 2853 0.138375172892804 4190 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_662 k832-1615 104 µM -1.0876525303002 0.145480761453027 no 2854 0.138374265597693 4200 5878478 SGTC_581 0958-0271 211 µM -1.08792113778922 0.145420445778061 no 2855 0.138314961848122 4175 4591145 SGTC_1664 st014217 9.02 µM -1.08824795740862 0.145347081284626 no 2856 0.138242829263959 4235 3982782 SGTC_2746 daunorubicin 9.88 µM -1.09277380758431 0.14433367794903 no 2857 0.137246562199672 4129 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2772 vinpocetine 57.06 µM -1.09508934079202 0.143817042482208 no 2858 0.136738749014846 4221 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1112 tnp00069 1.16933 µM -1.09514087964352 0.143805557485699 no 2859 0.136727460804647 4205 145826 SGTC_1275 0867-0008 21.1 µM -1.09719495400748 0.143348328166838 no 2860 0.13627808925713 4156 3422836 SGTC_2982 9019404 25.97 µM -1.09745798218949 0.143289850050114 no 2861 0.136220619435953 4129 22333232 SGTC_80 0159-0065 512.242 µM -1.09822639817584 0.143119103160021 no 2862 0.136052820916622 4090 1548079 SGTC_3249 9135183 49.47 µM -1.10312735428811 0.142033314417194 no 2863 0.134985931639618 4188 4902779 SGTC_64 000l-0018 272.079 µM -1.10549578350636 0.141510601312101 no 2864 0.134472410223441 4119 6811119 SGTC_1105 epirubicin 18.1 µM -1.1055141480829 0.141506553343409 no 2865 0.134468433673983 4229 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_78 0336-0123 156.75 µM -1.10607117268888 0.141383809783495 no 2866 0.13434785744234 4034 6765896 SGTC_355 1311-2252 105 µM -1.10786942112459 0.140988048059844 no 2867 0.133959106745152 4193 5338538 SGTC_34 0469-0683 81.75 µM -1.10805769201987 0.140946656560094 no 2868 0.133918450530601 4161 3690923 SGTC_2705 st078069 42.8 µM -1.10989903446389 0.140542270560066 no 2869 0.133521268310564 4261 1530061 SGTC_962 1254-0300 21.5 µM -1.11094656512016 0.140312569166603 no 2870 0.133295675196184 4175 7340576 SGTC_2163 5671233 125 µM -1.11278559879398 0.139909924844092 no 2871 0.132900260948626 4176 701023 SGTC_1992 st073643 23.3 µM -1.1155185241914 0.139313020656333 no 2872 0.132314142428189 4178 3161292 SGTC_2748 diazoxide 86.69 µM -1.11662431359353 0.139071995869395 no 2873 0.132077495678107 4268 3019 A potassium channel activatior. SGTC_1630 st005209 31.3 µM -1.12468613943186 0.137323369560643 no 2874 0.130361028601816 4192 3367314 SGTC_3237 9133362 49.47 µM -1.12481219110307 0.137296148450242 no 2875 0.130334313659761 4196 43845137 SGTC_1876 myriocin 605 nM -1.12577252676897 0.13708888303147 no 2876 0.130130907878602 4219 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_994 3910-0338 138 µM -1.12599383239219 0.137041149844518 no 2877 0.130084064968891 4286 3479481 SGTC_2667 digitoxin 100 µM -1.12679842093919 0.136867704654793 no 2878 0.129913859153768 4152 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2873 9040596 71.43 µM -1.13149922066487 0.135857352639533 no 2879 0.128922515629985 4197 6463863 SGTC_2915 7971052 15.16 µM -1.13288330879066 0.135560843638264 no 2880 0.128631630115663 4133 5741558 SGTC_2968 9090663 33.37 µM -1.13333756150337 0.135463627166896 no 2881 0.128536261884224 4184 25236811 SGTC_1413 3910-0535 34.4 µM -1.13369395197103 0.135387388046289 no 2882 0.128461473735569 4245 2876951 SGTC_2528 xanthyletin 44.79 µM -1.13496308551429 0.135116133595401 no 2883 0.128195392784708 4252 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1246 0422-0085 105 µM -1.14040464114568 0.133957324942948 no 2884 0.127058880100373 4263 264295 SGTC_820 1582-0060 59.9 µM -1.14198330391624 0.133622422023466 no 2885 0.126730479870801 4247 3848840 SGTC_2742 clothiapine 36.27 µM -1.14622977618512 0.13272441976626 no 2886 0.125850045248695 4246 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1555 citronellol 128 µM -1.14836550359373 0.132274351594613 no 2887 0.125408854127084 4193 8842 A terpine precursor. SGTC_3058 9093861 49.47 µM -1.14852915621498 0.132239908038958 no 2888 0.125375091926504 4262 17217477 SGTC_2665 lovastatin 100 µM -1.14878759632233 0.132185527391931 no 2889 0.125321787604879 4255 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_3294 9122953 26.2835 µM -1.14979535710946 0.131973622901156 no 2890 0.125114083989541 4219 16459826 SGTC_2468 5987765 72.9 µM -1.15013966666757 0.131901277759171 no 2891 0.125043175514598 4282 26772094 SGTC_2852 9023854 51.95 µM -1.15098619650305 0.131723524142189 no 2892 0.124868957165336 4282 19798528 SGTC_3252 9135871 49.47 µM -1.15155016937362 0.131605193378366 no 2893 0.124752984049397 4253 17682838 SGTC_1283 0922-0125 16.4 µM -1.15350933036646 0.131194699445932 no 2894 0.124350695062658 4237 3360884 SGTC_2894 9048625 32.47 µM -1.15436284531617 0.131016143254531 no 2895 0.124175720555959 4252 4092861 SGTC_2898 9056270 58.44 µM -1.15446990556687 0.13099375799858 no 2896 0.12415378487344 4232 19154699 SGTC_2430 5571206 200 µM -1.15520247728315 0.130840655293681 no 2897 0.124003760255231 4251 1731771 SGTC_2495 cafestol 54.53 µM -1.15823121146585 0.130208982512484 no 2898 0.123384847253281 4262 16667697 An anti-infammatory. SGTC_1695 st026914 34.495 µM -1.16031806579389 0.129774977944223 no 2899 0.122959665900529 4219 3289191 SGTC_229 benomyl 22.8748 µM -1.16135544346862 0.12955960694377 no 2900 0.122748690437404 4265 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.1633379081175 0.129148714535058 no 2901 0.122346215531764 4258 3256 An antibiotic and ribosome inhibitor. SGTC_325 2810-4341 181 µM -1.16409447241648 0.128992144857903 no 2902 0.122192864239953 4250 774970 SGTC_602 3130-1533 38.1 µM -1.16552019690992 0.12869745149675 no 2903 0.121904244854853 4301 720941 SGTC_270 tamoxifen 5.46 µM -1.16744465475333 0.128300412627295 no 2904 0.121515423317751 4310 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2183 6420625 130.508 µM -1.16867055047221 0.12804793944054 no 2905 0.121268195744171 4267 2897619 SGTC_156 3474-0145 5.642 µM -1.16937650797477 0.127902704216156 no 2906 0.121125985222104 4118 2265471 SGTC_228 caffeine 993.056 µM -1.16985796706645 0.127803720275195 no 2907 0.121029065745403 4265 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2202 7226349 200 µM -1.17074325045403 0.127621852426715 no 2908 0.1208509973844 4222 844334 SGTC_2785 7756463 72.73 µM -1.17133836008747 0.127499697482721 no 2909 0.120731399059577 4230 2201551 SGTC_1932 st074806 40.9 µM -1.17240355746049 0.127281253218378 no 2910 0.120517535957545 4331 17251235 SGTC_3073 9114972 49.47 µM -1.17523932404298 0.126700980883096 no 2911 0.119949490875655 4264 41905075 SGTC_320 4092-0846 5.34 µM -1.17579456885554 0.126587579217806 no 2912 0.11983848861735 4217 1359356 SGTC_680 0417-1641 114 µM -1.17750932492769 0.126237808546622 no 2913 0.119496138917324 4264 2835990 SGTC_2600 tangeritin 87.95 µM -1.17834513991519 0.126067565970802 no 2914 0.119329519466026 4190 68077 A bioactive flavone. SGTC_361 000s-0510 1.45 µM -1.17958145788398 0.125816040730888 no 2915 0.119083360600385 4193 660 SGTC_1409 3909-8004 61.9 µM -1.1825713051458 0.125209212564322 no 2916 0.11848954520642 4313 2119279 SGTC_772 k072-0172 35.3 µM -1.18659628515666 0.124395522709084 no 2917 0.117693450960115 4317 5861980 SGTC_184 1494-0393 24.714 µM -1.19031883103146 0.123646270897845 no 2918 0.116960551075592 4242 3090647 SGTC_1234 0326-0494 15.5 µM -1.19139801156003 0.123429651952939 no 2919 0.116748686588266 4357 1547813 SGTC_3286 9117135 37.221 µM -1.19206722294125 0.123295457844903 no 2920 0.116617443907372 4249 3438150 SGTC_1548 st061468 90.8 µM -1.19528893929237 0.122650851605825 no 2921 0.115987079866787 4275 390799 SGTC_2502 avocadyne acetate 18.59 µM -1.19540706274704 0.122627262285994 no 2922 0.115964013781973 4221 3952079 SGTC_1751 st044839 27.194 µM -1.19586025341336 0.122536789387284 no 2923 0.115875549004141 4313 5291326 SGTC_2757 clomiphene 4.22 µM -1.19630697080608 0.122447654628909 no 2924 0.115788394746022 4303 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_865 0488-0499 301 µM -1.1970390219832 0.122301684824313 no 2925 0.115645672733217 4234 9634651 SGTC_1330 1469-0054 61.8 µM -1.19819066022283 0.122072297346557 no 2926 0.115421400284696 4285 7102664 SGTC_743 1275-0778 158 µM -1.19885666862029 0.12193977734774 no 2927 0.115291841557911 4256 2849257 YMR203W TOM40 SGTC_1487 3970-0795 2.82 µM -1.19891806606564 0.121927565789891 no 2928 0.115279903108496 4342 3765103 SGTC_2372 9071633 200 µM -1.20003007126403 0.121706543747026 no 2929 0.115063830906938 4322 21321366 SGTC_1028 k015-0029 4.8 µM -1.20165279119505 0.121384517521799 no 2930 0.114749039432435 4250 4588309 SGTC_205 1486-1330 71.903 µM -1.2055636703862 0.120610872817136 no 2931 0.113992887102207 4342 4118834 SGTC_407 eburnamonine 100 µM -1.20691898473377 0.120343578182507 no 2932 0.113731672806002 4138 3195 SGTC_995 3931-2021 34.6 µM -1.2094421786168 0.119847066881586 no 2933 0.113246506262 4282 730143 SGTC_769 0302-0231 76 µM -1.20968814459059 0.11979874334019 no 2934 0.113199290360297 4201 571869 YER009W NTF2 SGTC_1369 1866-0067 208 µM -1.21048405026306 0.119642470421502 no 2935 0.113046603680939 4318 3531355 SGTC_2931 9014674 55.67 µM -1.22274977747245 0.117252309306506 no 2936 0.11071210986481 4268 2996810 SGTC_1439 4092-1168 46 µM -1.22563959342302 0.1166941424704 no 2937 0.110167165655861 4308 2886240 SGTC_1210 3013-0140 750 nM -1.22575590881214 0.116671715706227 no 2938 0.110145271946498 4333 905973 SGTC_1512 0259-0544 12.2 µM -1.22695505685209 0.11644068618413 no 2939 0.109919741711723 4275 18476 SGTC_2549 cedrol 20.94 µM -1.23117431952937 0.115630377443657 no 2940 0.109128836986181 4255 6708665 A sedative which affects the nervous system. SGTC_2741 miltefosine 3.04 µM -1.23225273707961 0.115423911830897 no 2941 0.108927344438134 4331 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2608 thymoquinone 42.66 µM -1.23263050733149 0.115351648812635 no 2942 0.108856824780308 4286 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_3323 9138564 53.9225 µM -1.2333692700675 0.115210425104292 no 2943 0.108719012299775 4321 43912313 YNL103W MET4 SGTC_2806 7952793 58.44 µM -1.23635041829496 0.114641790326413 no 2944 0.10816416881737 4357 2972490 SGTC_1704 st028805 70.8 µM -1.24198699438839 0.113572113928817 no 2945 0.107120680303797 4362 2876101 SGTC_2750 bromebric acid 70.15 µM -1.24387090916104 0.113216187306732 no 2946 0.106773538770246 4333 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_3054 9094397 49.47 µM -1.24451589447826 0.11309451376786 no 2947 0.106654876615665 4315 2598354 SGTC_360 0957-0399 1.01 µM -1.24655301435692 0.112710833240978 no 2948 0.106280719505952 4330 6752301 YPR165W RHO1 SGTC_951 1171-0579 82.7 µM -1.2485337817493 0.112338658546277 no 2949 0.105917822554653 4286 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2135 5326629 150.42 µM -1.25127563804317 0.111824929966069 no 2950 0.105416965269506 4277 5020077 SGTC_1907 st060210 83.7 µM -1.25324663035859 0.111456674004644 no 2951 0.105057982284093 4348 688793 SGTC_365 0121-0052 13.6 µM -1.2540157359651 0.111313211635836 no 2952 0.104918142943156 4338 3101739 SGTC_3108 9121785 49.47 µM -1.25481823955278 0.111163660467355 no 2953 0.104772374870058 4156 17140271 SGTC_3233 9132340 49.47 µM -1.25537541935115 0.111059911456871 no 2954 0.104671254111268 4333 17682950 SGTC_1207 2099-0101 141 µM -1.25602074264139 0.110939836481876 no 2955 0.104554224843206 4338 5837381 SGTC_982 1491-0518 27.5 µM -1.25840777498958 0.110496490836552 no 2956 0.104122160752041 4268 3091256 SGTC_664 1222-0054 14.9 µM -1.25927144224308 0.110336394478632 no 2957 0.103966152254651 4300 6813991 SGTC_447 ml7 120 µM -1.25953302839599 0.11028793758579 no 2958 0.103918934113782 4382 4216 Selective myosin light chain kinase inhibitor. SGTC_3277 9138724 49.47 µM -1.26051005956287 0.110107084773848 no 2959 0.103742710645349 4295 15943418 SGTC_1841 st054148 70 µM -1.26176759253999 0.109874623101433 no 2960 0.103516213336726 4364 675442 SGTC_885 0865-0106 16.8 µM -1.26435145119366 0.109398088876986 no 2961 0.103051955018641 4289 2793380 SGTC_1319 1306-0155 43.7 µM -1.26468515526766 0.109336653124437 no 2962 0.102992106732587 4386 3122360 SGTC_2383 9036125 200 µM -1.26476911766816 0.109321199340201 no 2963 0.102977052439769 4262 79580 SGTC_2699 st077704 54.6 µM -1.2651129855988 0.1092579247544 no 2964 0.102915414277331 4345 645852 SGTC_1239 0337-0584 35.4 µM -1.26863824592337 0.108610764402944 no 2965 0.102285058471822 4413 914301 YML130C ERO1 SGTC_1988 st071872 53.4 µM -1.2688153859642 0.108578318291633 no 2966 0.102253458121339 4367 16414116 SGTC_1645 Cervolide 78 µM -1.26941129396412 0.108469219123273 no 2967 0.102147205079807 4354 23173 A fragrance. SGTC_617 3770-0098 35 µM -1.26991962770108 0.108376215452605 no 2968 0.102056630420388 4254 5962639 SGTC_2009 4012297 12.05 µM -1.27022400191407 0.108320555259836 no 2969 0.102002425148558 4318 45595307 SGTC_1352 1496-0991 99 µM -1.27069067805882 0.108235255252222 no 2970 0.101919356605836 4339 3000039 SGTC_938 3126-1755 342 µM -1.27089157102629 0.108198550519759 no 2971 0.101883612739165 4340 1777771 SGTC_3193 9111931 49.47 µM -1.27180407789985 0.10803194107902 no 2972 0.101721369860923 4342 17087244 SGTC_1032 k061-1018 98.7 µM -1.27514287967148 0.107423902838695 no 2973 0.101129337275927 4397 4005393 SGTC_1727 st034309 9.9045 µM -1.27622245465783 0.107227827251359 no 2974 0.100938446564059 4408 870305 SGTC_1307 1187-1599 12.2 µM -1.27694503833865 0.107096733717319 no 2975 0.10081082597884 4345 1538471 SGTC_654 1124-0271 80.9 µM -1.27991808362116 0.10655857014664 no 2976 0.100286973494364 4329 5403748 SGTC_1010 4112-3296 15.2 µM -1.2850597087299 0.105632475129971 no 2977 0.0993857099020475 4385 704384 SGTC_2745 rifampicin 24.3 µM -1.28647543735934 0.105378502933296 no 2978 0.0991385928781457 4434 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_311 1315-0136 58 µM -1.29070139280825 0.104623022752651 no 2979 0.0984036207611108 4368 6759207 SGTC_545 4218-0007 221 µM -1.29134644544794 0.10450805175 no 2980 0.0982917860459421 4336 2840508 SGTC_110 0850-0284 111.64 µM -1.29218859721493 0.104358088567958 no 2981 0.0981459198017973 4208 3906265 SGTC_683 panaxydol 45 µM -1.29282754356334 0.104244414553603 no 2982 0.0980353559264668 4369 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1701 st028638 40.4 µM -1.29317858857967 0.104181998859257 no 2983 0.0979746496270192 4365 3490878 SGTC_2186 6124449 200 µM -1.29376386216797 0.104077997639859 no 2984 0.0978734993824814 4361 3834182 YLR033W RSC58 SGTC_2263 7948595 193.29 µM -1.29417931375589 0.104004218933771 no 2985 0.0978017451868464 4370 2971371 SGTC_3095 9117207 49.47 µM -1.29914018446079 0.103126162622752 no 2986 0.0969479123249059 4345 17015229 SGTC_1998 st075797 76.8 µM -1.29999992280504 0.102974540993232 no 2987 0.0968004978144021 4343 24208315 SGTC_3234 9132280 49.47 µM -1.30154700352168 0.102702109137451 no 2988 0.0965356432769442 4378 17612295 SGTC_1155 4088-0394 48.2 µM -1.30180346444467 0.102656998533151 no 2989 0.0964917896000347 4353 2326248 SGTC_2339 9000433 200 µM -1.30313255188147 0.102423447279342 no 2990 0.0962647560259772 4366 2988954 SGTC_3352 9151559 45.5865 µM -1.30529266550937 0.102044690256498 no 2991 0.0958966052971401 4385 17159339 SGTC_1677 st019204 53.9 µM -1.30534991223613 0.10203466642477 no 2992 0.09588686277433 4383 3945625 SGTC_3094 9117742 49.47 µM -1.30581667455684 0.1019529636492 no 2993 0.0958074540862377 4322 17149698 SGTC_31 0508-1974 57.237 µM -1.3059129505578 0.101936117278427 no 2994 0.0957910809969628 4305 6810525 SGTC_618 k072-0232 33.2 µM -1.30889562450849 0.101415212263478 no 2995 0.0952848544854922 4415 5872756 YGL099W LSG1 SGTC_2261 9010538 184.68 µM -1.30958368029679 0.1012953234246 no 2996 0.0951683561285437 4372 6457250 SGTC_3325 9138760 55.175 µM -1.31378099722821 0.100566206463476 no 2997 0.0944599571308179 4312 43844959 SGTC_1815 st051655 58.2 µM -1.31927524700348 0.0996175948919225 no 2998 0.0935385549956559 4319 5984156 SGTC_1416 3966-0321 25.3 µM -1.32044685875255 0.0994161584351574 no 2999 0.0933429337141363 4419 582530 YLR208W SEC13 SGTC_3177 9107506 49.47 µM -1.32604647162693 0.0984575224283209 no 3000 0.0924121524297268 4341 8897194 SGTC_426 0988-0037 14.6 µM -1.32936903229738 0.0978919195793476 no 3001 0.0918631247101542 4420 5383008 SGTC_312 4092-0653 6.84 µM -1.3311228157711 0.0975943332447418 no 3002 0.0915743013835967 4279 1148278 SGTC_394 menadione 8.33 µM -1.33165404541436 0.0975043239185431 no 3003 0.0914869483032607 4403 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_704 1310-0270 142 µM -1.33190030544339 0.0974626193103796 no 3004 0.0914464753369588 4385 5718033 SGTC_2937 9044753 11.33 µM -1.33285862337872 0.0973004508548954 no 3005 0.0912891015829772 4320 6465530 YGL099W LSG1 SGTC_2876 9059903 25.97 µM -1.33577644049875 0.0968079112283206 no 3006 0.0908111778526967 4377 6916095 SGTC_2022 5136654 200 µM -1.33617254715081 0.0967411881786744 no 3007 0.0907464409732368 4397 1713771 SGTC_1745 st081495 74 µM -1.33632704303349 0.0967151729399169 no 3008 0.0907212005411467 4246 13842402 YBL026W LSM2 SGTC_1238 0333-0287 48.8 µM -1.3380906096892 0.0964185736345062 no 3009 0.0904334507296123 4373 7226 SGTC_23 0213-0011 39.996 µM -1.34195221003552 0.09577145896068 no 3010 0.0898057457704961 4391 627608 SGTC_625 k213-0058 121 µM -1.3422840103828 0.0957160063307592 no 3011 0.0897519629344316 4467 3655420 SGTC_1781 st038725 66.3 µM -1.34292885091479 0.0956083039628998 no 3012 0.0896475066643317 4384 4270275 YIL048W NEO1 SGTC_506 n9-isopropylolomoucine 153 µM -1.34410901711092 0.0954114215913792 no 3013 0.0894565683332083 4401 6610355 SGTC_1944 st076371 56.9 µM -1.34762921839931 0.0948259335458229 no 3014 0.0888888340512447 4369 24208455 SGTC_2960 9079389 5.97 µM -1.35055048869315 0.0943420746368099 no 3015 0.0884197350319543 4386 16457355 SGTC_2353 9059630 146.67 µM -1.35402495490429 0.093768961785174 no 3016 0.0878642081611199 4440 4779114 SGTC_3093 9117344 49.47 µM -1.35464607136794 0.0936667800558506 no 3017 0.0877651737134768 4418 24824913 SGTC_1235 benzylparaben 21.5 µM -1.35931016538547 0.0929021014256646 no 3018 0.0870241620921184 4431 7180 SGTC_2033 5192550 145 µM -1.36034110546625 0.0927337032987175 no 3019 0.0868610031240493 4413 182073 SGTC_1813 st051246 8.6015 µM -1.36037342306423 0.092728428056734 no 3020 0.0868558921631238 4358 5291959 SGTC_1804 st050076 49.1 µM -1.36382642868449 0.0921660674718548 no 3021 0.086311100140091 4444 3895976 SGTC_775 4577-0580 57.3 µM -1.37907385764704 0.0897130212404774 no 3022 0.0839359915747876 4449 2006902 SGTC_2109 5483026 200 µM -1.37995751776245 0.0895723582031366 no 3023 0.083799862674412 4424 759335 SGTC_2854 9024559 71.43 µM -1.38342741184038 0.0890215987812878 no 3024 0.0832669251317287 4434 3163529 SGTC_968 1309-0633 340 µM -1.38621182392908 0.0885814686320676 no 3025 0.0828411160388335 4458 3761976 SGTC_1148 3909-7663 27.7 µM -1.38744066404627 0.0883877430524983 no 3026 0.0826537162920305 4466 4084526 SGTC_2434 5670830 169.91 µM -1.38848040071761 0.0882240761811397 no 3027 0.0824954044062072 4441 1549830 SGTC_3136 9095672 49.47 µM -1.38946771478059 0.0880688704454871 no 3028 0.0823452858695516 4279 17217380 SGTC_2217 6934799 96.0675 µM -1.39041517084233 0.0879201218834663 no 3029 0.0822014211432357 4408 675606 SGTC_1410 3909-8106 77.9 µM -1.39279697532305 0.0875470113644007 no 3030 0.0818405966681761 4493 1039210 SGTC_187 1488-2104 32.728 µM -1.39513261163306 0.0871822818158682 no 3031 0.0814879268002299 4434 2852859 SGTC_717 1532-0246 73.2 µM -1.39646105713851 0.0869753405534989 no 3032 0.0812878498827858 4407 9561992 SGTC_2457 5731572 11.68 µM -1.39718070859144 0.0868633887433364 no 3033 0.0811796181936004 4477 2865357 SGTC_2870 9038528 12.99 µM -1.39947352329014 0.0865074274016085 no 3034 0.0808355163115322 4455 6463316 SGTC_1131 3454-3128 32.3 µM -1.40092058950673 0.0862833312010317 no 3035 0.0806189105055909 4437 710982 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.40191806724658 0.0861291123377798 no 3036 0.0804698573081019 4403 756377 SGTC_1350 1495-0454 146 µM -1.40288086240826 0.0859804513719959 no 3037 0.0803261842834888 4471 1069057 SGTC_1652 st011932 78 µM -1.40907413825945 0.0850287618031732 no 3038 0.0794066235388911 4377 1551076 SGTC_382 3229-0966 23.2 µM -1.41133280035309 0.0846836564159372 no 3039 0.0790732536378119 4478 5722370 SGTC_3339 9145883 14.936 µM -1.41145926299145 0.0846643650425453 no 3040 0.0790546196166633 4361 2030670 SGTC_1895 st058434 18.3 µM -1.41362943858398 0.0843338267683121 no 3041 0.0787353665016624 4434 5393175 SGTC_182 3448-4371 550.524 µM -1.41824694167932 0.0836337610582159 no 3042 0.0780593406869183 4362 3491403 SGTC_762 1165-0429 115 µM -1.4206373072639 0.0832730741711931 no 3043 0.0777111134196349 4443 5967793 SGTC_2828 7998861 71.43 µM -1.42077591437739 0.0832521954037233 no 3044 0.0776909574351739 4438 2988188 SGTC_2489 cantharidin 73.42 µM -1.42311179521385 0.0829009271133875 no 3045 0.0773518747906268 4409 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_152 4469-0003 551.229 µM -1.42600808914362 0.0824669340125826 no 3046 0.0769330035564915 4435 697280 SGTC_3179 9107801 49.47 µM -1.42807724549098 0.0821579318092663 no 3047 0.0766348130678127 4441 4818259 SGTC_1642 st009582 77.7 µM -1.43073469951783 0.0817623551934872 no 3048 0.0762531321876187 4437 6739311 SGTC_668 1682-0499 62.6 µM -1.4309907670993 0.0817243140940026 no 3049 0.0762164306449534 4437 682214 SGTC_766 1391-0721 126 µM -1.43137200385414 0.0816677027300547 no 3050 0.0761618138202524 4472 1020919 YIL115C NUP159 SGTC_147 4466-0538 29.23 µM -1.43213353030198 0.0815547091533106 no 3051 0.0760528050432306 4509 6742687 YHR072W ERG7 SGTC_2285 7945142 200 µM -1.43445798974885 0.0812105401790023 no 3052 0.0757208046573113 4466 2970608 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.43616008267531 0.0809592171787885 no 3053 0.075478397328992 4443 6708760 SGTC_3295 9122362 53.5725 µM -1.43864894741817 0.0805927806566271 no 3054 0.0751250053613037 4450 4730473 SGTC_996 3970-0799 1.8 µM -1.43949358085607 0.0804687100745215 no 3055 0.0750053636928915 4444 6615648 YGL040C HEM2 SGTC_1549 4'-methoxyflavonol 74.6 µM -1.44366200840697 0.0798585105863334 no 3056 0.07441703656336 4410 97141 SGTC_676 falcarinol 140 µM -1.45065946512027 0.078842058180299 no 3057 0.0734373539692539 4487 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2839 9003951 25.97 µM -1.45381204184878 0.0783873296085232 no 3058 0.0729992119990785 4510 2990634 SGTC_2007 4011539 71.82 µM -1.45410778148567 0.0783447742713949 no 3059 0.0729582132637469 4426 45595301 SGTC_1725 st036284 20.55 µM -1.45632255204049 0.0780266374092756 no 3060 0.0726517370352152 4488 707914 SGTC_1157 4092-0394 27.6 µM -1.45723943337586 0.0778952208231739 no 3061 0.0725251494889225 4530 3659885 SGTC_2552 juarezic acid 87.02 µM -1.45830117342325 0.0777432515873987 no 3062 0.0723787734695111 4415 1549512 SGTC_2374 9071832 200 µM -1.45903719227949 0.0776380357084165 no 3063 0.0722774356849819 4409 17381698 SGTC_3173 9105693 49.47 µM -1.46054407857964 0.0774229595433094 no 3064 0.0720703012613303 4445 17096658 SGTC_1967 st070177 51.4 µM -1.46630277085197 0.0766051955836254 no 3065 0.0712829104757618 4476 5729214 SGTC_2843 9000894 45.46 µM -1.46647345657818 0.076581057963353 no 3066 0.07125967364796 4461 2242070 SGTC_2058 5236698 133 µM -1.46718369685213 0.0764806810396577 no 3067 0.0711630453361622 4440 766665 SGTC_2177 5811945 192 µM -1.46997078352782 0.0760877541414215 no 3068 0.0707848335146757 4489 5343475 SGTC_2819 7996655 46.38 µM -1.47670284068744 0.0751450011990402 no 3069 0.0698776551877807 4447 6456960 SGTC_1556 plumbagin 1.48 µM -1.47768762146092 0.0750078431492955 no 3070 0.0697457045771589 4414 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1011 4112-3381 17.4 µM -1.48053975889678 0.0746116811408752 no 3071 0.0693646292042143 4524 2877139 SGTC_658 3253-0951 102 µM -1.48648601893115 0.073790883193401 no 3072 0.0685753061179241 4503 1184878 SGTC_2193 5925765 200 µM -1.48830031741022 0.0735418237892923 no 3073 0.0683358556517149 4496 877370 SGTC_1111 tnp00062 510.699 nM -1.48968250095319 0.0733525151033994 no 3074 0.0681538689420569 4502 676306 SGTC_2747 doxorubicin 7.63 µM -1.4916315791417 0.0730861962543452 no 3075 0.0678978774344147 4541 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2113 5491891 107.031 µM -1.49276286038474 0.0729319595726669 no 3076 0.0677496361311291 4485 789979 SGTC_430 0958-0115 16.4 µM -1.4948665585216 0.0726458080719603 no 3077 0.0674746357198358 4426 6833180 SGTC_1166 k206-0078 225 µM -1.49579543599141 0.0725197332752494 no 3078 0.067353485537663 4512 5404595 SGTC_1144 3486-0183 12.5 µM -1.49651420691334 0.0724222909234696 no 3079 0.0672598542526681 4499 6744069 SGTC_593 1203-0218 61.7 µM -1.50396364811651 0.0714182839891767 no 3080 0.0662953635032642 4536 3666956 SGTC_830 4076-0286 57.8 µM -1.50455892092353 0.0713385186404391 no 3081 0.0662187571297025 4544 6866659 SGTC_621 3584-0052 32.1 µM -1.50601700226134 0.0711434276015687 no 3082 0.0660314045389533 4526 2273927 SGTC_697 0508-1955 564 µM -1.50643390080097 0.0710877220269963 no 3083 0.0659779117530159 4503 6243113 SGTC_1328 1441-0025 69.2 µM -1.50663894822347 0.0710603360827156 no 3084 0.0659516141774412 4488 4562601 SGTC_774 k060-0086 136 µM -1.50748452550011 0.0709474871552289 no 3085 0.0658432536887554 4495 5911235 SGTC_476 mead acid 10 µM -1.51012605169036 0.0705958413658611 no 3086 0.0655056315727944 4570 5312531 An omega 9 fatty acid. SGTC_1468 k284-1086 134 µM -1.51093846353797 0.0704879611004979 no 3087 0.0654020649541062 4506 15996457 SGTC_2115 tiliquinol 12.7705 µM -1.5124426901315 0.0702885492907642 no 3088 0.0652106408241933 4477 71208 A bioactive hydroxyquinoline. SGTC_1178 0988-0033 191 µM -1.51841294961465 0.0695013616829472 no 3089 0.0644551645903675 4562 5392207 SGTC_930 2810-3379 265 µM -1.51954515878575 0.0693528469860003 no 3090 0.0643126650356537 4502 1015764 SGTC_1609 st001574 46.4 µM -1.51955330514575 0.0693517792941139 no 3091 0.0643116406247348 4499 3960012 SGTC_1796 st049173 110.4 µM -1.52093693276522 0.0691706196033878 no 3092 0.0641378323192267 4492 94134 SGTC_2944 9067346 25.62 µM -1.52315027518765 0.0688815830130045 no 3093 0.0638605565882837 4434 6473075 SGTC_2091 4-phenylthiadiazole 200 µM -1.52402086823263 0.0687681492369191 no 3094 0.0637517491551119 4523 270010 SGTC_2128 5255449 168.493 µM -1.52609503801633 0.0684984760324571 no 3095 0.0634930988250298 4441 736008 SGTC_3086 9117350 49.47 µM -1.52706021360127 0.0683732671832301 no 3096 0.0633730195760798 4485 2679265 SGTC_336 4111-0029 111 µM -1.52710650766654 0.0683672660574585 no 3097 0.0633672644931927 4529 3131175 SGTC_61 0978-8327 98.565 µM -1.52747193456966 0.068319909826938 no 3098 0.0633218504417882 4433 6150059 YHR072W ERG7 SGTC_10 0279-0212 42.575 µM -1.52791757751125 0.0682621925392839 no 3099 0.0632665017017137 4525 39851 YBR002C RER2 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.53414979550485 0.0674589665691863 no 3100 0.0624964026585912 4510 75037 A free radical scavenger. SGTC_1092 toremifene 6.32 µM -1.53584664812084 0.0672415414605443 no 3101 0.0622879978734937 4510 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2576 guaiol 23.12 µM -1.53817302163476 0.0669443341748343 no 3102 0.0620031577479036 4413 227829 SGTC_206 4546-0025 72.014 µM -1.53862406410087 0.0668868287505489 no 3103 0.061948050131519 4544 6620745 YIL048W NEO1 SGTC_3125 9127534 49.47 µM -1.54050804111212 0.0666470451726541 no 3104 0.0617182821308199 4434 1639235 SGTC_1997 st073024 93.8 µM -1.54232005700733 0.0664170486341256 no 3105 0.0614979186698466 4561 686268 SGTC_2073 5212005 126 µM -1.54349682086428 0.0662680131615258 no 3106 0.0613551391277801 4427 691789 SGTC_922 1866-0035 480 µM -1.54480091625623 0.066103154025816 no 3107 0.0611972128079761 4451 3156169 SGTC_1121 fusaric acid 630.51 nM -1.54648313190643 0.0658909637371124 no 3108 0.0609939653909135 4492 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2329 6138490 200 µM -1.54764768998665 0.0657443788879536 no 3109 0.0608535713823813 4538 720019 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.54940921464468 0.065523133398794 no 3110 0.0606416900299382 4530 7104 SGTC_3139 9095020 49.47 µM -1.54959908025169 0.0654993210061394 no 3111 0.0606188869318504 4395 25236292 SGTC_1396 3511-0007 98.6 µM -1.55003207490873 0.0654450411792818 no 3112 0.0605669088199998 4549 X1396 SGTC_1371 2421-0008 32.7 µM -1.55162604269926 0.0652455233537224 no 3113 0.0603758640338193 4520 2827552 SGTC_1571 st070080 73.4 µM -1.55341819461396 0.065021762647012 no 3114 0.0601616294598291 4517 4315245 SGTC_2661 dactinomycin 12.96 µM -1.5551169346558 0.0648102152605222 no 3115 0.0599591112294245 4517 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_3118 9124250 49.47 µM -1.55704851896468 0.0645703210590463 no 3116 0.0597294831872223 4491 1504786 SGTC_2571 chrysanthemic acid 100 µM -1.55837358301661 0.0644061532636635 no 3117 0.0595723575393352 4507 2743 An insecticide. SGTC_2845 9003024 42.97 µM -1.55955173150761 0.0642604599967141 no 3118 0.0594329253094554 4554 2990173 SGTC_561 1550-0330 72.9 µM -1.56069994226017 0.0641187155098173 no 3119 0.0592972824532201 4489 6812934 SGTC_619 1652-1634 108 µM -1.56185018159741 0.0639769644224721 no 3120 0.0591616434517533 4524 5400454 SGTC_2970 9090938 41.86 µM -1.56559673639247 0.0635169424626573 no 3121 0.0587215272621584 4558 17217104 SGTC_2030 5175110 200 µM -1.5720639555836 0.062728924712426 no 3122 0.0579678598440239 4531 2831986 SGTC_2367 9070478 135.38 µM -1.57291027495816 0.0626263686110142 no 3123 0.0578697977935345 4461 572802 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.57448487616557 0.0624359079044728 no 3124 0.0576876976259137 4558 23665772 A membrane-active detergent. SGTC_577 r071-0003 38.6 µM -1.57527075934765 0.0623410181109218 no 3125 0.0575969801884853 4503 4568517 YMR134W ERG29 SGTC_3105 9121040 49.47 µM -1.58129315662059 0.0616175853180028 no 3126 0.056905511805525 4509 41448907 SGTC_2027 5150920 200 µM -1.58436513238277 0.0612511015124109 no 3127 0.0565553258857892 4496 786715 SGTC_3299 9121982 43.1275 µM -1.58481547999929 0.0611975189076069 no 3128 0.0565041321065192 4537 17594604 YPL160W CDC60 SGTC_873 0591-4978 488 µM -1.58680053126963 0.0609617728742474 no 3129 0.056278914241699 4558 3305145 SGTC_3129 9127257 49.47 µM -1.58879935597371 0.0607251090648919 no 3130 0.0560528493638088 4465 837894 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.59067838909345 0.0605032845962512 no 3131 0.0558409864408827 4541 61125 An anti-inflammatory. SGTC_2236 dapsone 200 µM -1.59786647220648 0.059660560671077 no 3132 0.0550363485873017 4574 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1449 4112-4002 201 µM -1.60458625466 0.0588810845734678 no 3133 0.0542924441844353 4580 2059539 SGTC_851 0394-0702 453 µM -1.60740083572154 0.0585569850295407 no 3134 0.0539832334415167 4555 762646 SGTC_3274 9138298 49.47 µM -1.60763307677054 0.0585303051056472 no 3135 0.0539577817571376 4512 17015756 SGTC_1793 st048256 72.231 µM -1.60803693088765 0.0584839329498572 no 3136 0.0539135453343688 4527 672022 SGTC_458 nppb 133 µM -1.60843585392521 0.0584381553283207 no 3137 0.0538698772351589 4576 4549 A chloride channel blocker. SGTC_1513 0337-0559 19 µM -1.60880160561955 0.0583962089492288 no 3138 0.0538298648498403 4531 775073 SGTC_741 4582-0002 126 µM -1.61620273932634 0.0575524773048379 no 3139 0.053025243364814 4572 2912688 SGTC_2327 6189656 200 µM -1.61884483559319 0.05725361053186 no 3140 0.0527403262658949 4596 5349088 SGTC_2646 retinol 96.75 µM -1.62033139384882 0.0570859928005423 no 3141 0.0525805542949602 4571 445354 A vitamin A analog and teratogen. SGTC_2357 9067248 200 µM -1.62114053449495 0.0569949201741981 no 3142 0.0524937512473158 4509 9150235 SGTC_1958 st076513 41.9 µM -1.62131158450741 0.0569756823374783 no 3143 0.0524754159047495 4487 732122 YGL099W LSG1 SGTC_2225 6654152 15.4 µM -1.6223722403262 0.0568565054802001 no 3144 0.0523618346318406 4504 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_148 3253-0744 288.01 µM -1.623528370419 0.0567268247071904 no 3145 0.0522382518424558 4441 6893655 SGTC_379 3970-0972 5.9 µM -1.62640013033496 0.0564057133042516 no 3146 0.0519322815679903 4564 2898042 YBL034C STU1 SGTC_1993 st073995 70.8 µM -1.62831885412136 0.0561919670623073 no 3147 0.0517286468459521 4561 3098394 SGTC_2398 5228213 48.84 µM -1.62882808480905 0.0561353460293799 no 3148 0.0516747087594095 4503 80771 YMR134W ERG29 SGTC_2583 asiatic acid 100 µM -1.64314561655737 0.0545617277070475 no 3149 0.0501764043415929 4566 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1690 st023502 41.2 µM -1.64472150789782 0.0543906763508981 no 3150 0.0500136276638689 4578 24207482 SGTC_1803 st050068 52.4 µM -1.64723062313936 0.0541192061350298 no 3151 0.0497553258331607 4585 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1125 tnp00248 1.32998 µM -1.64884476876319 0.0539451334861102 no 3152 0.0495897203090358 4589 24207736 SGTC_1102 cgs 12066b 26.1 µM -1.64926006107547 0.0539004193128932 no 3153 0.0495471840364392 4592 6438352 A 5-HT1B full agonist. SGTC_877 0771-0151 33.1 µM -1.65068979073157 0.053746705902828 no 3154 0.0494009667703949 4572 6166523 SGTC_2483 5729050 27.16 µM -1.65208841685257 0.0535966726291466 no 3155 0.0492582639465259 4548 2865180 SGTC_3314 9135860 59.4275 µM -1.65406626890277 0.0533850712551012 no 3156 0.0490570243722423 4551 25252478 SGTC_2350 9023895 38.85 µM -1.65624163338394 0.0531531040349138 no 3157 0.0488364475540968 4536 2997209 SGTC_3069 9117009 49.47 µM -1.67051003076928 0.0516513616702117 no 3158 0.0474092482526652 4581 41904981 SGTC_3260 9137109 49.47 µM -1.6720607703304 0.0514901997922505 no 3159 0.0472561696650981 4562 17478346 SGTC_2619 obliquin 87.91 µM -1.67607724123858 0.0510746435845801 no 3160 0.0468615319871918 4567 6708593 A bioactive alkalod. YER133W GLC7 SGTC_689 0833-0039 98 µM -1.6771200370494 0.0509671903861336 no 3161 0.0467595056777968 4546 5374726 SGTC_62 0180-0423 3.232 µM -1.67838507342745 0.0508370784171378 no 3162 0.0466359748271595 4530 30102 YGL099W LSG1 SGTC_686 1319-0111 510 µM -1.67841597334942 0.0508339035993138 no 3163 0.0466329607280967 4581 4562600 SGTC_2458 5808907 16.39 µM -1.68834447239428 0.0498219454419248 no 3164 0.0456725614590876 4678 2731747 SGTC_2413 inermin 26.06 µM -1.69188795422539 0.0494646928388396 no 3165 0.0453336695779964 4609 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1984 st072354 53.1 µM -1.69258020394301 0.0493951397958229 no 3166 0.0452677008923896 4488 5762938 SGTC_525 k781-2675 26.7 µM -1.69293738847144 0.0493592826134417 no 3167 0.0452336928227005 4531 3651118 YDL195W SEC31 SGTC_2020 4017018 200 µM -1.70243155399863 0.0484137732155712 no 3168 0.0443372495742306 4605 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2765 myclobutanil 7.74 µM -1.70352102067413 0.0483062076515181 no 3169 0.0442353038037343 4597 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1786 berberine 21.6 µM -1.70467876902758 0.0481921100888265 no 3170 0.0441271758080649 4494 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2977 9011197 71.43 µM -1.70749676635458 0.047915293936969 no 3171 0.0438648791600997 4609 2704722 SGTC_2768 sulfasalazine 50.2 µM -1.70872377163005 0.047795161789544 no 3172 0.0437510643123199 4564 5384001 An antioxidant and salicylic acid derivative. SGTC_557 1315-0110 16.2 µM -1.71116770592887 0.0475566026201852 no 3173 0.0435250791896763 4572 6833801 SGTC_889 0919-1524 82.7 µM -1.71197542660196 0.0474779688161318 no 3174 0.0434505985513667 4616 3905452 SGTC_821 1114-0266 29.2 µM -1.71467828242726 0.0472155956832171 no 3175 0.0432021137190228 4615 3123235 SGTC_1872 amphotericin b 148 nM -1.71844380992001 0.0468520051116406 no 3176 0.0428578476072844 4602 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_897 1000-0139 31.4 µM -1.71857694223817 0.0468391913843855 no 3177 0.0428457165847312 4569 6151020 SGTC_533 1222-0222 6.71 µM -1.72942446880828 0.04580454810252 no 3178 0.0418665769260251 4624 3982874 SGTC_1057 3448-5381 134 µM -1.73042515812673 0.045710034465148 no 3179 0.0417771710882297 4593 5497911 SGTC_1245 0418-0076 17.2 µM -1.73656003589924 0.0451340257612515 no 3180 0.0412324293796941 4600 6790114 SGTC_1888 azatryptophan 97.5 µM -1.73763394997242 0.0450337983824571 no 3181 0.0411376668715023 4617 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_208 k072-0098 12.366 µM -1.74014969184712 0.0447997078619458 no 3182 0.0409163683342826 4607 5948901 SGTC_1859 st055998 20 µM -1.74509266139654 0.0443426172398126 no 3183 0.0404843703982196 4543 676301 SGTC_2284 7945075 39.21 µM -1.74829318783575 0.0440486652273677 no 3184 0.0402066361143458 4559 1245402 SGTC_1643 st009866 20.2 µM -1.75392446160439 0.043535277439323 no 3185 0.0397217257387425 4599 3156273 YOR207C RET1 SGTC_2711 st079103 59.1 µM -1.75824243908004 0.0431448995931071 no 3186 0.0393531335187672 4552 54693780 SGTC_711 k292-0785 179 µM -1.76064563797901 0.0429288599337648 no 3187 0.039149199539147 4558 4146315 SGTC_3152 9099253 49.47 µM -1.76107751062931 0.0428901288230355 no 3188 0.03911264243647 4455 25236131 SGTC_2000 st075254 36.4 µM -1.7628347927004 0.0427328237553958 no 3189 0.0389641787171583 4512 17234175 SGTC_973 1325-0077 65.9 µM -1.76355928338991 0.042668106083617 no 3190 0.0389031039670125 4621 2835149 SGTC_575 k072-0246 11.9 µM -1.77355961368908 0.0417828614723583 no 3191 0.038068011487193 4685 6796779 SGTC_1430 4049-0248 69.1 µM -1.77626580202088 0.0415458798299136 no 3192 0.0378445585171906 4634 22774488 SGTC_2356 9061756 188.97 µM -1.7835208894764 0.0409159196403899 no 3193 0.0372507753108377 4638 20104043 SGTC_991 3996-0057 64.7 µM -1.78638638341698 0.0406692527227658 no 3194 0.0370183593985688 4635 715343 SGTC_119 0121-0043 24.815 µM -1.78825867310128 0.0405087355154198 no 3195 0.0368671420391278 4621 1092378 SGTC_1117 retinoic acid 1.10837 µM -1.78837833922959 0.0404984936785384 no 3196 0.0368574942813925 4654 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1581 himbacine 57.9 µM -1.79076878920407 0.040294342867709 no 3197 0.0366652028445526 4637 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2080 5212524 12.4 µM -1.79167530664972 0.0402171427691734 no 3198 0.036592496139816 4588 260183 SGTC_1874 staurosporine 7.6 µM -1.8029580733572 0.0392663058064153 no 3199 0.0356973997368677 4613 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1999 st074831 12.5 µM -1.80432892145349 0.0391520365622835 no 3200 0.0355898792305275 4608 17112523 SGTC_534 k292-0788 63.4 µM -1.80678626402639 0.0389478783920777 no 3201 0.0353978056145304 4665 4146317 SGTC_1257 0669-0121 16 µM -1.81108665274076 0.0385926848363579 no 3202 0.0350637196433023 4617 4307855 SGTC_103 0844-0104 51.839 µM -1.81146116309743 0.0385618772480529 no 3203 0.0350347478024659 4447 5375804 SGTC_25 0118-0223 35.662 µM -1.81429481721594 0.0383294270410324 no 3204 0.0348161745316446 4615 5333628 SGTC_640 3381-0960 37.1 µM -1.81533849560454 0.0382441004455438 no 3205 0.0347359532780815 4680 1745025 SGTC_2103 5378138 10 µM -1.82058847815256 0.0378172310103086 no 3206 0.034334717782586 4683 244142 SGTC_2815 7968870 71.43 µM -1.8224808527637 0.0376643210735221 no 3207 0.0341910282035774 4556 2977326 YHR190W ERG9 SGTC_3042 9091578 49.47 µM -1.82709586563012 0.037293528914992 no 3208 0.0338426783882522 4631 25236497 SGTC_3124 9127567 49.47 µM -1.838688566942 0.0363752570483329 no 3209 0.0329805029949619 4601 17592030 SGTC_2188 6126565 140.678 µM -1.84096172510066 0.036197385551205 no 3210 0.0328135839224531 4564 874518 SGTC_1908 st060353 56.5 µM -1.84413452445149 0.0359503096359038 no 3211 0.0325817687859859 4628 4227716 SGTC_2250 alverine citrate 130 µM -1.85064660567809 0.035447520325315 no 3212 0.0321102051012877 4509 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2460 5552655 174.22 µM -1.85159307066212 0.0353749272190122 no 3213 0.0320421394156304 4620 5401989 SGTC_137 0438-0332 85.389 µM -1.86285203301473 0.0345206891799126 no 3214 0.0312415435008391 4585 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_455 paf C-16 10 µM -1.86671852443598 0.0342312695253977 no 3215 0.0309704527313856 4623 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_739 1486-1183 203 µM -1.86993251951225 0.0339922121295827 no 3216 0.0307465946188252 4646 4346692 SGTC_387 norethindrone acetate 66.7 µM -1.87116014253449 0.0339012644794624 no 3217 0.0306614437243382 4652 541197 SGTC_154 3389-1638 511.116 µM -1.87424331341687 0.0336737321035756 no 3218 0.0304484483534728 4650 5238686 SGTC_2814 7977482 42.97 µM -1.88910892196445 0.0325942480825398 no 3219 0.0294386175974293 4628 6456762 SGTC_860 0443-0016 25.1 µM -1.88929382691229 0.0325810028480779 no 3220 0.0294262341282628 4652 5337942 SGTC_1545 lovastatin 49.4 µM -1.89358859241441 0.0322746042815288 no 3221 0.0291398194290051 4678 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_3083 9117465 49.47 µM -1.89805216540042 0.0319586866712984 no 3222 0.0288446052840809 4612 16420915 SGTC_2207 7258803 200 µM -1.90158723955238 0.0317103012993627 no 3223 0.0286125687278718 4683 3666799 SGTC_847 0342-0274 5.54 µM -1.90658567735329 0.0313618195914805 no 3224 0.0282871306254056 4653 18097 SGTC_1794 st048918 76.9 µM -1.90712551861451 0.0313243730705559 no 3225 0.0282521677254275 4653 672303 SGTC_799 1310-0557 151 µM -1.91226154439893 0.0309699544645967 no 3226 0.0279213278330189 4670 5354492 SGTC_1636 st007707 68.9 µM -1.91606904838807 0.0307093597516016 no 3227 0.0276781536917298 4667 403051 SGTC_429 1112-0049 25.5 µM -1.93288343527978 0.0295801638183631 no 3228 0.0266252794527748 4624 2836170 SGTC_1457 k015-0032 57.3 µM -1.93442698480937 0.0294782540913884 no 3229 0.0265303256548556 4669 4302660 SGTC_712 r015-0009 80.6 µM -1.93564684553818 0.0293979216088542 no 3230 0.0264554843692054 4688 6813872 YLR060W FRS1 SGTC_2055 5235184 200 µM -1.93911838289592 0.0291703018028165 no 3231 0.0262434623846763 4657 2836034 SGTC_158 k038-0087 26.446 µM -1.94073121882624 0.0290650514479842 no 3232 0.026145443809272 4590 X158 SGTC_914 3820-6779 408 µM -1.94505553333558 0.028784411834385 no 3233 0.0258841474588934 4596 2893481 SGTC_722 3534-0461 190 µM -1.94749588719677 0.0286270345080298 no 3234 0.0257376561764374 4677 658262 SGTC_1466 k213-0079 57.5 µM -1.95659906805814 0.0280462750243567 no 3235 0.0251973123405541 4674 3657981 SGTC_2964 9083345 53.42 µM -1.95697017611969 0.0280228089644246 no 3236 0.0251754874356261 4643 17741579 SGTC_1655 st012546 55.1 µM -1.95710767346689 0.0280141188270175 no 3237 0.0251674052250903 4673 720985 YLR208W SEC13 SGTC_531 3788-1495 174 µM -1.95887512775792 0.0279026115013997 no 3238 0.0250637062522747 4664 2896655 SGTC_679 0422-0091 41.4 µM -1.9643576285464 0.0275590744729934 no 3239 0.0247443164683179 4679 627384 YHR062C RPP1 SGTC_1808 st050063 61.5 µM -1.96896311785116 0.0272732232257497 no 3240 0.0244786632712726 4652 4011993 SGTC_220 paclitaxel 373.376 µM -1.9698239070926 0.0272200714514513 no 3241 0.0244292778214318 4667 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1047 2043-3044 82 µM -1.97017367101974 0.0271984990299219 no 3242 0.0244092349750717 4646 669592 SGTC_1579 chlormadinone acetate 49.4 µM -1.97238566833706 0.0270623995722313 no 3243 0.0242827983194127 4703 45114258 A steroidal progestin. SGTC_230 MPP+ 141.667 µM -1.97460911564307 0.0269261688548213 no 3244 0.0241562618963629 4667 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_204 PMA1.184 62.41 µM -1.97474899590725 0.026917617559504 no 3245 0.024148319861016 4666 2252213 YGL008C PMA1 SGTC_1524 corynanthine 62.1 µM -1.97497860756453 0.0269035856331298 no 3246 0.0241352878672785 4709 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_3202 9113761 49.47 µM -1.97989001813599 0.0266049009151075 no 3247 0.0238579441410132 4608 4798415 SGTC_3075 9116269 49.47 µM -1.98170897434287 0.0264949873313033 no 3248 0.0237559111042656 4663 17015205 YNL244C SUI1 SGTC_3027 9089541 49.47 µM -1.98309746642599 0.0264113408749668 no 3249 0.0236782717809154 4668 9943819 SGTC_2086 5274770 176.623 µM -2.00217174457411 0.0252844242441013 no 3250 0.022633131730206 4703 689278 SGTC_2551 apiole 73.87 µM -2.00535461286859 0.0251003581969999 no 3251 0.0224625751057357 4644 10659 A possible DNA adduct former. SGTC_1184 1269-1718 139 µM -2.0075518803987 0.0249739460685697 no 3252 0.0223454661677318 4714 5403821 SGTC_2248 tofa 1.1 µM -2.01709204901608 0.0244312592612734 no 3253 0.0218429541149449 4704 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_189 3970-0742 2.116 µM -2.0277392875129 0.0238373215455349 no 3254 0.021293431825131 4684 2891807 SGTC_1878 temozolomide 1 mM -2.03303917476764 0.0235462304575391 no 3255 0.0210242826627554 4662 5394 DNA alkylating agent. SGTC_3060 1327-0027 12.5 µM -2.03550367897346 0.0234118918758606 no 3256 0.020900109374666 4625 16000455 YPR107C YTH1 SGTC_2912 7964298 10.93 µM -2.04006209306912 0.0231651149741526 no 3257 0.0206720708216205 4671 2975850 SGTC_1916 st067606 49.2 µM -2.05368119142699 0.0224408335432265 no 3258 0.0200032790656767 4597 19590279 SGTC_2309 7664088 163.95 µM -2.06098840899735 0.0220601620737081 no 3259 0.0196520729533904 4669 704922 SGTC_2328 6201408 200 µM -2.06162609599824 0.0220272017409889 no 3260 0.019621673783677 4645 2890418 SGTC_2879 9041815 71.43 µM -2.06524625590213 0.0218408723092731 no 3261 0.0194498529454307 4725 4942971 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -2.09056165153647 0.0205747398020598 no 3262 0.0182836882023588 4719 4174840 SGTC_2532 xanthone 78.9 µM -2.10387598728818 0.0199341607197676 no 3263 0.017694633066192 4705 7020 An insecticide. SGTC_247 mechlorethamine 29.705 µM -2.11156173664281 0.0195721465916137 no 3264 0.0173620286983562 4711 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_3063 1327-0034 4 µM -2.12908944904146 0.0187673928240131 no 3265 0.0166234302675858 4609 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3322 9139058 2.11 µM -2.13726016437425 0.0184019783306691 no 3266 0.0162884184843585 4724 4908926 YPR165W RHO1 SGTC_281 1672-3440 14.9 µM -2.13779627073479 0.0183782156622334 no 3267 0.0162666409121084 4734 6833000 SGTC_3150 9097574 49.47 µM -2.13843573820365 0.0183499057473296 no 3268 0.0162406972523765 4721 17217476 SGTC_2010 4012422 159 µM -2.14195958425272 0.0181945668207173 no 3269 0.0160983672097715 4676 952393 SGTC_2692 st077426 47.7 µM -2.14365321642457 0.0181203073954457 no 3270 0.0160303416864878 4695 25238571 SGTC_815 1582-0027 36.9 µM -2.1511491693521 0.0177947323189532 no 3271 0.0157322138057967 4718 3128206 SGTC_497 capsazepine 133 µM -2.15701927830439 0.0175432696752073 no 3272 0.0155020811873038 4671 2733484 A calcium channel blocker. SGTC_1264 0783-0040 158 µM -2.15941865735316 0.01744136231149 no 3273 0.0154088508626239 4658 2855798 SGTC_1208 2323-2347 50.3 µM -2.18889559590834 0.0162300955937982 no 3274 0.0143022146286242 4722 5412760 SGTC_2102 5377816 72.7585 µM -2.19372861612507 0.0160385363715282 no 3275 0.0141274626595745 4727 1379702 SGTC_1925 st057770 10.1 µM -2.20238084336094 0.0157004387678085 no 3276 0.0138192089516202 4703 5989122 SGTC_708 3448-5400 146 µM -2.20385114544508 0.0156435967449903 no 3277 0.0137674071499676 4697 3462195 SGTC_2716 st080858 38.6235 µM -2.20456986363187 0.015615875340933 no 3278 0.0137421462206848 4709 5296050 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -2.20458267269537 0.0156153816700073 no 3279 0.0137416963808973 4716 688803 SGTC_2840 9008771 71.43 µM -2.2097110866288 0.015418801724812 no 3280 0.013562609912873 4698 2992978 SGTC_1467 k284-1082 293 µM -2.21991414903938 0.0150340146085471 no 3281 0.0132122979320677 4712 3334705 SGTC_2069 5228469 200 µM -2.22097788348549 0.0149943772807011 no 3282 0.0131762297009096 4715 2835210 SGTC_1906 st060206 94.7 µM -2.22339369324259 0.0149046918706938 no 3283 0.0130946323009305 4726 5133468 SGTC_667 1498-1044 59 µM -2.23466797526529 0.01449221488141 no 3284 0.0127195772796334 4728 6739982 SGTC_2323 6148992 148.28 µM -2.2492863129101 0.0139720521654831 no 3285 0.0122471430300008 4699 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_882 0843-0131 351 µM -2.2637292507578 0.0134740174380254 no 3286 0.0117953861361251 4744 5425421 SGTC_1456 k015-0012 13 µM -2.26432995332535 0.0134536397249462 no 3287 0.0117769143143158 4724 2989616 SGTC_735 3076-0345 636 µM -2.27804593817819 0.012995537357578 no 3288 0.011361920369822 4737 2888990 SGTC_2948 9070189 9.45 µM -2.28254017486105 0.0128483964217186 no 3289 0.011228734202043 4682 6473636 YDL196W YDL196W SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -2.31310859231457 0.0118853017044259 no 3290 0.0103583347132352 4715 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_3170 9103054 49.47 µM -2.3320734234405 0.0113198080811482 no 3291 0.00984841444622175 4720 16432970 SGTC_195 4234-0266 16.654 µM -2.34324840515245 0.0109976612736759 no 3292 0.00955832532059164 4764 2303354 SGTC_3190 9110366 49.47 µM -2.35526434830977 0.0106601988047216 no 3293 0.00925476645905287 4731 17123768 SGTC_1674 st016616 23.6 µM -2.36036527600558 0.0105196907720346 no 3294 0.00912847419602332 4736 625830 SGTC_734 2023-0417 80 µM -2.36297814120202 0.0104483448865369 no 3295 0.00906436942360123 4746 3935732 SGTC_3144 9087057 49.47 µM -2.36356401700241 0.0104324051930958 no 3296 0.00905004960837712 4692 17249618 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -2.37381033131052 0.0101570446968501 no 3297 0.00880279576583312 4759 5393153 SGTC_3107 9121808 49.47 µM -2.37846500932221 0.0100340632116322 no 3298 0.00869244340089224 4716 662681 SGTC_85 0868-0259 160.055 µM -2.39447574488093 0.00962091150805712 no 3299 0.00832207213138833 4742 83173 SGTC_2194 5927483 104.545 µM -2.39687989662066 0.00956017479652574 no 3300 0.00826767132858917 4768 760979 SGTC_2556 citropten 84.59 µM -2.42058363409265 0.00897906113539612 no 3301 0.00774780717414921 4723 2775 A potential DNA crosslinker. SGTC_910 3454-3003 490 µM -2.43470598274651 0.00864775350572282 no 3302 0.0074519471931136 4691 820824 SGTC_291 SEC14.278 35.5 µM -2.45978128608479 0.00808584631245741 no 3303 0.00695108541474744 4761 1068044 SGTC_1912 st060209 90.8 µM -2.48483774217737 0.00755667095172405 no 3304 0.00648052477775662 4738 688787 SGTC_2144 5628481 200 µM -2.51959128953785 0.00687326718343817 no 3305 0.00587455846961676 4773 2818399 SGTC_1446 4239-0190 62 µM -2.52783739589644 0.00671935602313723 no 3306 0.0057383745872922 4769 1340085 SGTC_751 0833-0568 350 µM -2.5309623305392 0.00666183068118233 no 3307 0.00568750320778707 4757 6954252 SGTC_2310 7668677 200 µM -2.53564813295045 0.00657638784522954 no 3308 0.00561197235816905 4718 2197143 SGTC_554 4483-2211 187 µM -2.54277923948677 0.00644821552096232 no 3309 0.00549873437689432 4777 747107 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -2.54914034904338 0.00633575312184367 no 3310 0.00539944156587041 4696 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2041 5107442 45.335 µM -2.5532962931109 0.00626321836840824 no 3311 0.00533543389943891 4775 793005 SGTC_871 0574-0004 149 µM -2.57192611909666 0.00594702552809735 no 3312 0.00505672357028873 4741 9551173 SGTC_1069 diphenylcyclopropenone 8.49 µM -2.59542431745405 0.00556843903044705 no 3313 0.00472371033092815 4776 65057 A dermal irritant. YDR527W RBA50 SGTC_2397 5161689 200 µM -2.59688061508578 0.00554569671687283 no 3314 0.00470373075026392 4760 2259942 SGTC_645 0845-0943 5.41 µM -2.60610046837297 0.00540361986995533 no 3315 0.00457897974659238 4777 1885106 SGTC_2636 apigenin dimethyl ether 100 µM -2.64710921338 0.0048101255519378 no 3316 0.00405915648541364 4746 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2679 rapamycin 1 nM -2.65390867347873 0.00471754626169478 no 3317 0.00397826789874541 4661 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2916 7875993 68.79 µM -2.65814297256584 0.00466069961487914 no 3318 0.00392862762414804 4742 1299250 SGTC_2150 5556613 200 µM -2.69743302374253 0.00416167381483407 no 3319 0.00349381698123834 4788 743190 SGTC_445 e6 berbamine 66 µM -2.70439413742279 0.00407842268139713 no 3320 0.00342145349462268 4783 6610268 A calcium/calmodulin antagonist. SGTC_3151 9099821 49.47 µM -2.72331352747976 0.0038596373221884 no 3321 0.00323153449093712 4755 17174189 SGTC_420 mitomycin C 81.9 mM -2.72767920579041 0.0038106705648687 no 3322 0.00318908010602796 4781 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_710 3448-4187 58 µM -2.73401360988344 0.00374061203346131 no 3323 0.00312837291048574 4757 3946412 SGTC_221 trifluoperazine 10.304 µM -2.73545663348324 0.00372481463019619 no 3324 0.00311468969616793 4752 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_3155 9099265 49.47 µM -2.76964388205004 0.0033676346556894 no 3325 0.00280588061107374 4768 25236499 SGTC_1931 st074438 57.1 µM -2.79241882955337 0.00314709160059575 no 3326 0.00261577957195535 4778 2787313 SGTC_280 3448-3607 3.04 µM -2.80417087428399 0.00303845182383576 no 3327 0.00252230810180103 4769 626179 SGTC_2550 chrysin dimethyl ether 71.87 µM -2.81258441128177 0.0029627618230565 no 3328 0.00245725612961637 4762 88881 An O-methylated flavonoid and antioxidant. SGTC_1202 1988-0068 29.6 µM -2.81448772498596 0.00294587666796589 no 3329 0.00244275217117311 4777 2850480 SGTC_3194 9111903 49.47 µM -2.85345466423887 0.00261871570677776 no 3330 0.00216233490265113 4770 17087251 SGTC_998 3996-0085 177 µM -2.8698235518763 0.00249135940477565 no 3331 0.00205350455263879 4776 715391 SGTC_684 1140-0066 328 µM -2.8887662311526 0.00235098757778008 no 3332 0.00193378239054971 4780 6813534 SGTC_297 0986-0032 24 µM -2.99283403030762 0.00169980110982511 no 3333 0.00138200007684292 4793 2847425 SGTC_1901 st060216 58.6 µM -3.00091884643643 0.00165683527861978 no 3334 0.00134583145150157 4787 688792 SGTC_562 3772-2733 112 µM -3.03509323160274 0.00148593307784123 no 3335 0.001202306711382 4774 2876874 YIL048W NEO1 SGTC_203 k066-0004 30.888 µM -3.03838517248532 0.00147035038487743 no 3336 0.00118924865497682 4795 6795412 SGTC_1715 st032160 10.2275 µM -3.06703772671988 0.00134088829239955 no 3337 0.00108095784621348 4744 5289825 SGTC_3175 9106517 49.47 µM -3.09133837375316 0.00123934732630491 no 3338 0.000996282129039323 4789 41468073 SGTC_58 0957-0393 9 µM -3.09148105405937 0.00123877248940363 no 3339 0.000995803456729575 4472 6997992 SGTC_2414 st077232 92.9 µM -3.14474115779311 0.00104046160782333 no 3340 0.000831169193511064 4780 729801 SGTC_3354 9151612 71.43 µM -3.15762150736209 0.000997094884134003 yes 3341 0.000795309660722051 4787 27261949 SGTC_2997 9067075 71.4286 µM -3.17078020508375 0.000954509616624725 yes 3342 0.000760150640776936 4787 27209819 SGTC_2829 7992743 58.44 µM -3.28891440845024 0.000640558829491242 yes 3343 0.000502873018207696 4774 16462845 SGTC_2292 7671323 168.05 µM -3.29254680855088 0.000632624504287963 yes 3344 0.000496421846367065 4793 937504 SGTC_1987 st072290 61.9 µM -3.33039366456791 0.000555185362956032 yes 3345 0.000433616401809439 4801 54697379 SGTC_673 1082-0474 110 µM -3.35986462174059 0.00050106020507681 yes 3346 0.00038990337089848 4795 3098046 SGTC_1963 st076565 50.3 µM -3.40015296729617 0.000434947720333483 yes 3347 0.000336740825450195 4805 4914280 SGTC_2808 7946468 45.46 µM -3.41895951815302 0.000406941499998836 yes 3348 0.000314305389032394 4790 2970879 SGTC_3201 9113999 49.47 µM -3.42125732928441 0.000403636803886172 yes 3349 0.000311661620769037 4788 16649224 SGTC_1522 st012842 45.6 µM -3.54442360127406 0.00025889615356316 yes 3350 0.000196736259566751 4762 3491067 YOR116C RPO31 SGTC_279 1273-0055 2.93 µM -3.63613166578743 0.00018434185402631 yes 3351 0.000138381454470578 4800 2847562 SGTC_1462 k081-0014 26.5 µM -3.63739252849977 0.000183473261262701 yes 3352 0.000137706024326763 4504 3270634 SGTC_3195 9113082 49.47 µM -3.67419427912824 0.000159744513499341 yes 3353 0.000119300569450703 4795 17018038 SGTC_3187 9109394 49.47 µM -3.9810483455224 4.79683695946555e-05 yes 3354 3.4305995586344e-05 4807 17098090 SGTC_284 0988-0104 32.6 µM -4.08008748778858 3.19379595515632e-05 yes 3355 2.25093769406131e-05 4797 4666532 SGTC_849 0386-0493 241 µM -4.66520008614727 2.40089920718717e-06 yes 3356 1.54158441305938e-06 4809 726119