SGTCid condition conc unit LRG1|YDL240W.score LRG1|YDL240W.strain.pval LRG1|YDL240W.strain.significant LRG1|YDL240W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1871 st057448 67.3 µM 7.76595729787941 3.0995079615146e-15 yes 1 4.05154254601194e-15 1 691747
SGTC_1966 st070145 16.1 µM 6.8685352093703 2.66990827847559e-12 yes 2 3.24322326095219e-12 4 3748532
SGTC_1962 st076595 64.5 µM 6.27251670026887 1.52594947828017e-10 yes 3 1.77629167697536e-10 5 279619
SGTC_1638 st008370 60.6 µM 5.34988081362282 3.99979848636668e-08 yes 4 4.40060879249731e-08 10 24207134
SGTC_1637 st007924 17.4 µM 5.32978685266888 4.4735331720683e-08 yes 5 4.91640496764467e-08 8 683336
SGTC_3191 9110352 49.47 µM 5.02991236418749 2.26797838062987e-07 yes 6 2.45352033854485e-07 1 17122424
SGTC_1001 4048-4355 44.4 µM 4.8209286156141 6.67243772722908e-07 yes 7 7.14457435065972e-07 20 21824233
SGTC_1862 st057513 3.81 µM 4.6976050929381 1.23630139055688e-06 yes 8 1.31614875796433e-06 3 5393163
SGTC_112 phenothiazine 287.218 µM 4.27599088226588 9.10159650743489e-06 yes 9 9.51445056565663e-06 9 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1865 st057639 52.2 µM 4.18832682321203 1.34882212490164e-05 yes 10 1.40509314110303e-05 8 688818
SGTC_2756 carbadox 75.1 µM 4.08265391972557 2.14577679410471e-05 yes 11 2.22621517821871e-05 53 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2675 theaflavin digallate 100 µM 4.08191047936816 2.15271446349294e-05 yes 12 2.23335013775077e-05 29 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2366 9070441 60.58 µM 3.95634276333106 3.68497287218146e-05 yes 13 3.80529706177864e-05 29 6837235
SGTC_3106 9121286 49.47 µM 3.92512380331713 4.20191753459071e-05 yes 14 4.33425719068826e-05 12 15943471
SGTC_518 1021-0119 62.6 µM 3.89926616294056 4.68123410909904e-05 yes 15 4.82423335602763e-05 41 1097762
SGTC_206 4546-0025 72.014 µM 3.67882074438856 0.000114537864664349 yes 16 0.00011715743961529 87 6620745 YIL048W NEO1
SGTC_1789 tunicamycin 25 nM 3.6488855305153 0.00012887009053934 yes 17 0.000131690210594585 60 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2296 7971656 126.45 µM 3.64806319287122 0.000129286577666483 yes 18 0.000132112328882821 52 666570
SGTC_837 0091-0265 12.5 µM 3.63756776592185 0.000134714219469581 yes 19 0.000137612396502899 32 759367
SGTC_519 k048-0011 62.8 µM 3.40606820487806 0.000324866315391164 yes 20 0.000329528560772995 37 6836379
SGTC_2546 rhodinyl acetate 100 µM 3.26602638429085 0.00053973412506867 yes 21 0.000545340433493494 29 6708682
SGTC_674 0498-0004 451 µM 3.13366652415265 0.00085727716933723 yes 22 0.000863184651642939 51 4231473
SGTC_840 0245-0196 390 µM 3.11370779193068 0.000917901325226128 yes 23 0.000923761823257975 45 3827528
SGTC_2775 cyproheptadine 69.59 µM 3.10617313963253 0.000941794180256402 yes 24 0.000947628545025691 38 2913 A selective serotonin reuptake inhibitor.
SGTC_212 3807-4682 38.772 µM 3.09549546487124 0.000976632987892483 yes 25 0.000982421888105698 134 3125501 YBL034C STU1
SGTC_188 3229-0966 278.469 µM 3.0867820990389 0.00100593516147491 no 26 0.00101167928637343 79 5722370
SGTC_3134 9127454 49.47 µM 3.07772837246973 0.00103723479937472 no 27 0.00104292472985355 34 24262820
SGTC_1967 st070177 51.4 µM 3.01079233081376 0.00129782544970667 no 28 0.001302834969782 58 5729214
SGTC_1005 4092-0690 4.4 µM 2.97552740376008 0.00145801158440896 no 29 0.00146242608353879 74 1529343
SGTC_1878 temozolomide 1 mM 2.92938279046133 0.00169485061166265 no 30 0.0016981793843693 41 5394 DNA alkylating agent.
SGTC_1964 st076914 61 µM 2.92098557705261 0.00174154119820052 no 31 0.0017446299018999 66 24208661
SGTC_1980 st071811 45.7 µM 2.88597655731993 0.00194907760987505 no 32 0.00195100610228799 59 4974850
SGTC_3300 9124615 50.48 µM 2.83304752499532 0.00230570724444767 no 33 0.00230532652919746 83 24824903
SGTC_196 k015-0023 18.111 µM 2.82720153581684 0.00234852019167496 no 34 0.00234783826243826 69 5211998
SGTC_839 0122-0028 230 µM 2.82338280094931 0.00237687385283906 no 35 0.00237598980782009 114 759448
SGTC_2472 5377652 49.4 µM 2.82194300671956 0.0023876443348367 no 36 0.00238668297141189 135 1610903
SGTC_282 k297-0036 65.7 µM 2.81882385720239 0.00241112898848545 no 37 0.00240999801004768 35 5061378
SGTC_2544 sphondin 68.51 µM 2.80792586693612 0.00249483191451595 no 38 0.00249308518032267 73 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2149 5554786 194.827 µM 2.80738984180507 0.00249901589792606 no 39 0.00249723793246744 110 745063 YPR165W RHO1
SGTC_1265 0819-1001 68.8 µM 2.80163356547075 0.00254434850799988 no 40 0.00254222945446858 77 3106768
SGTC_2601 securinine 100 µM 2.77037062549782 0.0028037891097077 no 41 0.00279962696263098 87 442872 A GABA receptor antagonist.
SGTC_2561 acetosyringone 100 µM 2.76210038347754 0.00287630032982578 no 42 0.00287154089667149 107 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1798 st045719 60.953 µM 2.75480607438523 0.00294165367264126 no 43 0.00293634660930055 54 3980186
SGTC_2541 muurolladie-3-one 83.07 µM 2.75300398229162 0.00295800432262668 no 44 0.00295255889689706 94 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_51 1013-0126 23.419 µM 2.74415813559487 0.00303945789236727 no 45 0.00303331529937739 76 1627850
SGTC_2837 9008476 45.46 µM 2.73018841645243 0.0031722130657608 no 46 0.00316490685262265 109 2992805
SGTC_2473 5854593 8.94 µM 2.72963523743645 0.00317757576884382 no 47 0.00317022185747428 56 2872951
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 2.72924641017679 0.00318135007208605 no 48 0.0031739625586894 34 4000243
SGTC_3204 9114183 49.47 µM 2.72503058861799 0.00322253234855099 no 49 0.00321477650323185 97 17027248
SGTC_1426 4048-4480 71.7 µM 2.72404387759009 0.00323224003700805 no 50 0.00322439691799506 76 14224343
SGTC_1239 0337-0584 35.4 µM 2.70378541508903 0.00343745413210682 no 51 0.00342772723689959 146 914301 YML130C ERO1
SGTC_650 1328-0195 38 µM 2.68791040052248 0.00360636506271946 no 52 0.00359503433748429 98 2780821
SGTC_2764 methyldopa 94.69 µM 2.66648258230381 0.00384616381718234 no 53 0.00383247890539035 104 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 2.66123197015907 0.00390706145144727 no 54 0.00389276494872714 127 442882
SGTC_1612 st002233 45.4 µM 2.65057663977251 0.00403330605522865 no 55 0.00401772471532209 88 1035021
SGTC_2395 5646831 180.19 µM 2.64725480573995 0.00407340326943887 no 56 0.00405740916077947 107 6808628
SGTC_3098 9119039 49.47 µM 2.64112742634107 0.00414830277006448 no 57 0.00413153172113702 111 17161528
SGTC_2360 9040895 200 µM 2.62405394838398 0.00436354638555241 no 58 0.00434450105332187 96 4914414
SGTC_1752 st044819 83.042 µM 2.61841443107465 0.00443680519663694 no 59 0.00441697221156406 115 441209 YML126C ERG13
SGTC_2286 7945697 125 µM 2.6045038068686 0.00462222607037214 no 60 0.00460036994151788 150 1245733
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 2.59989486945028 0.00468516847172866 no 61 0.00466261620391864 107 6708514
SGTC_1199 1638-0010 4.46 µM 2.58550887667114 0.0048865790199463 no 62 0.0048617684515712 113 3111136
SGTC_8 0354-0001 70 µM 2.58332083874744 0.00491787943155237 no 63 0.00489271380998102 193 4993152
SGTC_2721 ifenprodil 61.44 µM 2.58004126474135 0.00496512912810309 no 64 0.00493942549256951 105 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_3212 9128307 49.47 µM 2.56567947280582 0.00517684049948893 no 65 0.00514869671899233 139 27243542
SGTC_680 0417-1641 114 µM 2.56258874655502 0.00522343875397947 no 66 0.00519475157437699 89 2835990
SGTC_157 1348-1695 65.819 µM 2.55677940612028 0.00531203593867767 no 67 0.00528230947619148 177 5380510
SGTC_2565 isoliquiritigenin 100 µM 2.55664586549516 0.00531408816169553 no 68 0.00528433753170601 123 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2304 7443016 91.4 µM 2.54479652758475 0.00549901707368483 no 69 0.00546707154939002 91 939854
SGTC_290 2043-6722 48.1 µM 2.5339034950362 0.00567404286666776 no 70 0.00563998960434238 104 773758 YLR208W SEC13
SGTC_2387 9077560 195.08 µM 2.51755981293823 0.00594592860255314 no 71 0.00590854516645305 110 5303272
SGTC_843 0310-0051 143 µM 2.50830601566705 0.00610493916546324 no 72 0.00606557782128835 105 2065037
SGTC_1002 4049-0206 172 µM 2.49035476560783 0.00642417851372468 no 73 0.00638078204031084 161 4662749
SGTC_3184 9108758 49.47 µM 2.47244558126465 0.0067573008802413 no 74 0.00670960711770163 61 902885
SGTC_2062 5245942 200 µM 2.4724190104882 0.00675780624544841 no 75 0.00671010589913936 127 1376160
SGTC_2323 6148992 148.28 µM 2.46020716163788 0.00699363520665319 no 76 0.00694284193224079 127 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_489 paxilline 115 µM 2.45588896390382 0.00707874809929305 no 77 0.00702682864859762 111 105008 A toxic potassium channel blocker.
SGTC_2760 etidronate 98.04 µM 2.44513712742578 0.00729465287538924 no 78 0.00723985382015889 145 3305 A chelator and antioxidant.
SGTC_3085 9117376 49.47 µM 2.42186119983245 0.00778203832238795 no 79 0.0077206235542655 104 16480349
SGTC_2753 fluvastatin 17.09 µM 2.42036961546692 0.00781422630236524 no 80 0.00775236921910347 132 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1076 itraconazole 331 nM 2.4147425699242 0.00793671328469515 no 81 0.00787316712386466 121 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2726 cimetidine 79.27 µM 2.39836236755067 0.00830293266461093 no 82 0.00823428208242386 69 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2205 7238770 200 µM 2.3945371126517 0.00839056331723683 no 83 0.00832067961043471 81 279867
SGTC_2109 5483026 200 µM 2.39196244283089 0.00845000119523817 no 84 0.00837927857947227 150 759335
SGTC_1768 st044301 37.178 µM 2.38931145230157 0.00851158681724336 no 85 0.00843999286238662 132 3931349
SGTC_2720 fluspirilene 36.88 µM 2.37509855672722 0.00884853096025414 no 86 0.00877213248917674 82 3396 An atypical antipsychotic.
SGTC_191 3914-0123 66.505 µM 2.37282227632216 0.00890356688659517 no 87 0.00882637779317734 47 3144412
SGTC_2935 9038016 29.96 µM 2.35366293528876 0.00937881141369711 no 88 0.00929472946155447 146 6463195
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 2.34901751915197 0.00949732928966344 no 89 0.00941151057322767 361 16725076
SGTC_3175 9106517 49.47 µM 2.3435336075189 0.00963892325556737 no 90 0.00955102060753704 111 41468073
SGTC_1900 st060200 72.8 µM 2.3397604344151 0.00973741434088499 no 91 0.00964805644216411 134 688945
SGTC_3044 9093193 49.47 µM 2.335315175175 0.00985457600040908 no 92 0.00976348099748327 168 25236277
SGTC_2148 5546263 113.568 µM 2.32921239691909 0.010017428420467 no 93 0.00992390824775177 136 792097
SGTC_2962 9082311 13.18 µM 2.32683963453097 0.0100813768360206 no 94 0.00998690102409715 146 16459453
SGTC_1664 st014217 9.02 µM 2.31301872703949 0.0104609911871991 no 95 0.0103608047704805 132 3982782
SGTC_357 1325-0123 420 µM 2.30837065920933 0.0105914278664619 no 96 0.0104892647333009 114 1098503
SGTC_2390 9097792 176.6 µM 2.30246781039693 0.0107591173716063 no 97 0.0106544023505354 125 4497149
SGTC_2393 9031399 185.94 µM 2.28990245081849 0.0111237908179804 no 98 0.0110134860701562 176 1526623 YDL150W RPC53
SGTC_2418 pentamidine 31.67 µM 2.28930890092558 0.0111412796231918 no 99 0.0110307054542191 171 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1974 st069448 26.9 µM 2.28203970763933 0.0113574117641444 no 100 0.0112434980269894 131 6323587 YNR016C ACC1
SGTC_1718 roemerine 11.9335 µM 2.25248794266274 0.0122739996997498 no 101 0.01214572691238 223 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1874 staurosporine 7.6 µM 2.2484521198071 0.0124040216964712 no 102 0.0122736874650279 180 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1819 st053448 58.6 µM 2.23403824944575 0.0128781789067054 no 103 0.0127402782201535 152 2857616
SGTC_3206 9114350 49.47 µM 2.23157544968334 0.0129607437517221 no 104 0.0128215178643338 149 17087243
SGTC_2623 humulene 100 µM 2.22969131271744 0.0130242176889599 no 105 0.0128839715071265 121 6187145 An anti-inflammatory.
SGTC_2433 5607874 27.82 µM 2.21938689937623 0.0133761334534371 no 106 0.0132302070769191 174 2252428
SGTC_1942 st076330 65.2 µM 2.20774691698963 0.0137835101005113 no 107 0.0136309601510647 179 24208414
SGTC_1022 4477-0945 21.3 µM 2.20483117980585 0.0138872157377017 no 108 0.0137329716064178 174 4648966
SGTC_1020 4335-0961 93.3 µM 2.20318104632255 0.0139462045510072 no 109 0.0137909953264985 157 669075
SGTC_2710 st078562 53.7235 µM 2.19484733541928 0.014247428645868 no 110 0.0140872753353493 153 17250908
SGTC_3338 9144300 39.5675 µM 2.18944760336478 0.0144455813367271 no 111 0.0142821614651043 172 4901274
SGTC_2915 7971052 15.16 µM 2.18442754251545 0.0146319249244835 no 112 0.0144654230941577 94 5741558
SGTC_3125 9127534 49.47 µM 2.17635363680763 0.0149359647595849 no 113 0.0147644138705134 114 1639235
SGTC_53 0973-0023 39.979 µM 2.1733858505254 0.0150490801546498 no 114 0.0148756444377303 152 674768
SGTC_322 k048-0136 19.3 µM 2.17316490543705 0.0150575307126383 no 115 0.0148839540482739 145 6823282
SGTC_117 lucigenin 22.078 µM 2.17260175822019 0.0150790880316489 no 116 0.0149051517254705 267 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_834 0312-0008 75.7 µM 2.16671238911643 0.0153061271018637 no 117 0.0151283956652282 215 6385573 YIL048W NEO1
SGTC_1902 st060212 70.5 µM 2.15757790011539 0.0156640740759568 no 118 0.0154803322344577 169 688944
SGTC_2278 7948257 134.34 µM 2.15722163889362 0.0156781789545926 no 119 0.0154941996077262 159 1247028
SGTC_1912 st060209 90.8 µM 2.15572150798683 0.0157376908325846 no 120 0.015552708844774 186 688787
SGTC_2389 9091542 195.52 µM 2.15322121861074 0.0158373107571457 no 121 0.0156506484232479 198 3626624 YOL127W RPL25
SGTC_96 0929-0093 37.281 µM 2.15256167951889 0.0158636789721664 no 122 0.0156765714589386 161 6991579
SGTC_991 3996-0057 64.7 µM 2.11184740393463 0.0175659633775411 no 123 0.0173497699332402 176 715343
SGTC_287 k060-0039 29.6 µM 2.10567869526312 0.0178370200895205 no 124 0.0176161358354526 164 5861974
SGTC_1963 st076565 50.3 µM 2.10399305969881 0.0179117056547546 no 125 0.0176895262106203 151 4914280
SGTC_773 4358-1457 44.6 µM 2.1025935204127 0.0179739176160624 no 126 0.0177506584144139 237 1186886
SGTC_950 1165-0508 94.1 µM 2.1016288759149 0.018016904929479 no 127 0.0177928991685159 193 6148369
SGTC_1642 st009582 77.7 µM 2.10111958611852 0.0180396356718441 no 128 0.0178152349931084 177 6739311
SGTC_1464 k208-0027 110 µM 2.10042940836522 0.0180704788620495 no 129 0.0178455421525046 182 X1464
SGTC_38 0929-0051 58.268 µM 2.09498650880904 0.0183152941761744 no 130 0.018086095895671 215 1379719
SGTC_1277 0873-0036 22 µM 2.08959036245333 0.0185607902937637 no 131 0.0183273065065264 233 5965735
SGTC_2945 9067681 61.76 µM 2.08019966783437 0.018994698552404 no 132 0.0187536113544433 150 16456930
SGTC_107 0358-0022 2.6945 µM 2.07632081622914 0.0191764270139637 no 133 0.0189321446549949 123 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_405 ebelactone b 50 µM 2.06883948422728 0.0195311121726386 no 134 0.0192805759420513 192 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_3208 9114115 49.47 µM 2.06660875704671 0.019637941894244 no 135 0.0193855174919615 231 650895
SGTC_2724 maprotiline 69.64 µM 2.06506484650297 0.0197121700917671 no 136 0.0194584325180147 166 4011 A tricyclic antidepressant.
SGTC_1479 0549-0158 134 µM 2.06369127614887 0.0197784087533873 no 137 0.0195234985128433 226 5440202
SGTC_431 k089-0097 107 µM 2.06120034199713 0.0198990128557502 no 138 0.0196419654642669 283 5499420
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 2.05486558431888 0.0202085387819317 no 139 0.0199459947035785 268 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_114 0364-0001 490.298 µM 2.04673259655845 0.0206119055741347 no 140 0.0203421734465797 253 4003655
SGTC_2155 5570423 76 µM 2.0374111884102 0.0210825810229538 no 141 0.0208044267985018 171 797402
SGTC_2587 piperic acid 92.2 µM 2.03599801766021 0.0211547255348 no 142 0.0208752771641005 209 5370536
SGTC_1965 Pectolinarigenin 58.4 µM 2.03015766705664 0.021455103302569 no 143 0.0211702576699909 188 5320438 An anti-inflammatory.
SGTC_2416 tofa 880 nM 2.0293749764561 0.0214956308802395 no 144 0.0212100559365555 251 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1341 1486-1360 280 µM 2.02487160020129 0.0217300741622966 no 145 0.0214402752414987 216 3976547
SGTC_146 3448-8650 53.125 µM 2.02029955508804 0.0219702983815145 no 146 0.021676162469078 401 2891488 YIL048W NEO1
SGTC_2035 5154463 94.595 µM 2.01640219173648 0.0221768401181906 no 147 0.0218789682603389 241 2769623
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 2.01204234335016 0.022409830725657 no 148 0.0221077368068393 207 4330530
SGTC_273 hydroxyurea 18.1 mM 2.01018971314495 0.0225094586250674 no 149 0.0222055568702725 273 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1210 3013-0140 750 nM 2.007812923664 0.0226378206432991 no 150 0.0223315874950456 177 905973
SGTC_2907 7721985 69.9 µM 2.0074241434195 0.0226588759028762 no 151 0.0223522601054987 229 3267881
SGTC_2725 haloperidol 53.21 µM 2.00559274739933 0.0227582813861895 no 152 0.0224498581665069 247 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2867 9039098 71.43 µM 2.00245880358804 0.0229292397553144 no 153 0.0226177047788661 236 6463460
SGTC_1728 st035614 33.7865 µM 2.00241407362624 0.0229316876084957 no 154 0.0226201080461628 302 15945546
SGTC_2096 5468907 200 µM 1.99917942687913 0.0231092885651692 no 155 0.0227944718532784 184 759785
SGTC_787 4152-0075 138 µM 1.98646571170196 0.0238186076554583 no 156 0.0234908182318806 215 9566539
SGTC_2335 9018011 154.17 µM 1.96787172535067 0.0248888903939544 no 157 0.0245413994139567 249 6458208
SGTC_2319 6033012 152.6 µM 1.96762895802739 0.0249031266859302 no 158 0.0245553726562704 184 847246
SGTC_903 1134-0042 114 µM 1.96396076949191 0.0251190679502821 no 159 0.0247673207876925 237 701009
SGTC_1559 coumarin 343 70.1 µM 1.96107324435922 0.0252901546183109 no 160 0.0249352396692525 188 108770 A hepatotoxic, DNA x-linker.
SGTC_1483 3453-0561 55.9 µM 1.96098529764766 0.0252953807684895 no 161 0.0249403689972064 253 4546991
SGTC_74 000s-0487 160.283 µM 1.95875865626674 0.0254279985809642 no 162 0.0250705287537674 237 677548
SGTC_3247 9135149 49.47 µM 1.94220518103751 0.0264322850881839 no 163 0.0260561330676676 186 8934436 YOR116C RPO31
SGTC_2363 9053361 176 µM 1.93317257142563 0.0269941253018706 no 164 0.0266074712262375 266 6469797 YMR079W SEC14
SGTC_1668 st014914 51.6 µM 1.93222389109981 0.0270537086693709 no 165 0.0266659387956179 208 2839556
SGTC_140 0062-0056 502.533 µM 1.92979029244504 0.0272070567506346 no 166 0.0268164133979471 271 3758964
SGTC_1004 4084-0029 199 µM 1.92787358486344 0.0273283439116802 no 167 0.026935426043337 241 716894 YLR208W SEC13
SGTC_2251 lansoprazole 556 µM 1.9262917672679 0.0274287789489358 no 168 0.0270339764116869 187 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1285 0929-0069 65.5 µM 1.92415540989817 0.0275649120033827 no 169 0.0271675532048936 232 1206237
SGTC_885 0865-0106 16.8 µM 1.91673345476768 0.0280422386645165 no 170 0.0276359013990393 259 2793380
SGTC_2266 7929956 200 µM 1.91645585425586 0.0280602246388908 no 171 0.0276535485969628 257 2967153
SGTC_108 0509-0257 621.132 µM 1.91545370206882 0.0281252348891084 no 172 0.0277173340640605 304 536624
SGTC_3113 9123498 49.47 µM 1.91172345861462 0.0283683212401125 no 173 0.0279558368907934 194 8897275
SGTC_1124 fisetin 1.16336 µM 1.91070924702369 0.0284347151912741 no 174 0.0280209779095216 235 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2437 5741531 144.16 µM 1.9018246561149 0.0290218776634493 no 175 0.0285970408813325 266 2262990
SGTC_3193 9111931 49.47 µM 1.8998190086125 0.0291558110838586 no 176 0.0287284377554922 255 17087244
SGTC_426 0988-0037 14.6 µM 1.89966248023219 0.0291662853242029 no 177 0.028738713552847 300 5383008
SGTC_2689 tacrolimus 100 µM 1.89110574627087 0.0297436411599278 no 178 0.0293051148072648 279 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2158 5657123 3.6195 µM 1.8855902761895 0.030120793463834 no 179 0.0296750943736876 210 2858827
SGTC_106 0092-0003 11.579 µM 1.88379758681873 0.0302442294861893 no 180 0.0297961800560717 194 1072148
SGTC_2399 5884133 200 µM 1.88261664261256 0.0303257724995122 no 181 0.0298761696594555 314 722445
SGTC_2939 9044578 71.43 µM 1.8821867265281 0.0303555029723777 no 182 0.0299053336128112 273 2653634
SGTC_1898 st060199 18.6 µM 1.88016386158789 0.0304957167903178 no 183 0.0300428745680426 227 688866
SGTC_2596 sinensetin 100 µM 1.87910418843523 0.0305693813510957 no 184 0.0301151341791844 253 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_18 0111-0177 500 nM 1.87826959777796 0.0306275027035352 no 185 0.0301721466877839 370 721752
SGTC_1685 st024049 53.0905 µM 1.87603703931814 0.0307834292745289 no 186 0.0303250970132422 221 1941139
SGTC_1919 st067113 52.3 µM 1.87568746055951 0.0308079039960711 no 187 0.0303491043809753 292 1268243
SGTC_1436 4092-1007 8.32 µM 1.86804727164122 0.0313468450736775 no 188 0.03087774109128 237 2881121
SGTC_2878 9043973 25.97 µM 1.86320865859562 0.031692177121891 no 189 0.0312164575770507 223 6465167
SGTC_3330 9141424 71.43 µM 1.86030712566138 0.031900763236934 no 190 0.0314210429953693 284 27261020
SGTC_1570 verbenone 133 µM 1.85788912724872 0.0320754539208823 no 191 0.0315923803621416 250 29025 A natural terpanoid with antifungal properties.
SGTC_1032 k061-1018 98.7 µM 1.85148285793099 0.0325421025691963 no 192 0.032050059306835 313 4005393
SGTC_3066 9117245 49.47 µM 1.84151052614031 0.0332796444833457 no 193 0.0327733897415111 259 17176980
SGTC_1645 Cervolide 78 µM 1.83985825372238 0.0334031640242571 no 194 0.0328945251585816 219 23173 A fragrance.
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.83731043245831 0.0335943720733262 no 195 0.0330820403351803 245 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_671 0560-0003 407 µM 1.83549526541802 0.0337311449317325 no 196 0.033216169983419 247 3238678
SGTC_3248 9135562 49.47 µM 1.83539186268169 0.0337389501031578 no 197 0.0332238242740297 269 17650701
SGTC_3089 9117425 49.47 µM 1.83486230480664 0.0337789461332659 no 198 0.0332630470755101 282 9401657
SGTC_1619 st003326 88.7 µM 1.8340410428308 0.0338410509149401 no 199 0.0333239509756041 212 2849032
SGTC_500 h-89 112 µM 1.83206023347049 0.0339912285778129 no 200 0.0334712235827303 299 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_3331 9141060 1.957 µM 1.83105725097987 0.0340674797842528 no 201 0.0335459991494268 263 4906567 YPR165W RHO1
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.82899066337699 0.0342250344865974 no 202 0.0337005034710838 269 7104
SGTC_3229 9132204 49.47 µM 1.82705456891734 0.0343731834605637 no 203 0.0338457825460729 181 17682924
SGTC_14 0354-0009 295 µM 1.82398038552036 0.034609500815192 no 204 0.0340775188115927 279 1713507
SGTC_1013 4112-3890 241 µM 1.82256867227255 0.0347184676984542 no 205 0.0341843720159995 287 705171
SGTC_929 2805-0021 398 µM 1.8181805733977 0.0350589750492798 no 206 0.0345182690932574 267 3098024
SGTC_2484 5809818 12.04 µM 1.8176659396395 0.0350990885017455 no 207 0.0345576032986868 268 2870548
SGTC_2987 9018338 71.43 µM 1.81136243088362 0.0355934819978946 no 208 0.0350423837450965 300 5055682
SGTC_1059 3448-6867 171 µM 1.80745929788907 0.0359024620748438 no 209 0.035345347723024 271 3934407
SGTC_1761 st044296 37 µM 1.80650326424101 0.0359784777606832 no 210 0.0354198823632758 272 1826700
SGTC_411 enrofloxacin 100 µM 1.80627650559006 0.0359965270144563 no 211 0.0354375799007422 252 71188 A bacterial gyrase inhibitor.
SGTC_3259 9138485 49.47 µM 1.80599962932692 0.0360185755234428 no 212 0.0354591987334097 302 17646153
SGTC_2684 capsaicin 100 µM 1.80561081903315 0.0360495563553205 no 213 0.0354895757647607 265 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_90 0870-0863 4.608 µM 1.79749747960857 0.0367010306295612 no 214 0.036128338946498 309 1738164
SGTC_747 3448-8087 38.7 µM 1.79365304223702 0.0370130717734228 no 215 0.0364342823477314 303 5168703
SGTC_1178 0988-0033 191 µM 1.79020303075843 0.037294941735273 no 216 0.0367106390294573 325 5392207
SGTC_3028 9087778 49.47 µM 1.78941575194873 0.0373595084689607 no 217 0.0367739421831752 256 17217395
SGTC_1530 rhein 70.4 µM 1.78217828550129 0.0379573594292871 no 218 0.0373600813423634 304 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1490 4089-0339 670 nM 1.78023858295559 0.0381189081734537 no 219 0.0375184617808992 200 742542
SGTC_1063 disulfiram 1.84 µM 1.78019443061417 0.0381225919329308 no 220 0.0375220732766448 294 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2087 5276107 200 µM 1.77742545111915 0.0383541967535221 no 221 0.03774913317981 284 144405
SGTC_1740 st038286 13.222 µM 1.7761116450103 0.0384644875668643 no 222 0.0378572586177368 308 716786
SGTC_2818 7996756 12.99 µM 1.77038694715023 0.038948082928523 no 223 0.0383313513373056 209 2241621
SGTC_524 r073-0010 27.8 µM 1.75625199917019 0.0401633625656877 no 224 0.0395226947097487 316 2772106
SGTC_39 0986-0283 58.349 µM 1.75222491573436 0.040515182221692 no 225 0.0398675704805158 356 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_3102 9121669 49.47 µM 1.74896176557742 0.0408020935108182 no 226 0.0401488143551532 242 41905072
SGTC_1362 1611-0397 101 µM 1.74484678741011 0.0411662493174353 no 227 0.0405057710409738 296 27816
SGTC_2257 7960413 200 µM 1.74000691348079 0.0415979225312082 no 228 0.040928902006011 344 2974689 YIL048W NEO1
SGTC_1972 st070201 17.4 µM 1.7356667997989 0.0419881334708204 no 229 0.0413113835506729 304 2829099
SGTC_1421 4029-0249 71.4 µM 1.73210350082777 0.0423107130123861 no 230 0.0416275679997906 333 2894095
SGTC_2634 4'-methoxyflavone 100 µM 1.73037190940148 0.0424681934299993 no 231 0.0417819246576343 301 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_277 nystatin 15.5 µM 1.72816944295276 0.0426691823882307 no 232 0.0419789251952543 326 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_587 k089-0003 57 µM 1.72733206425734 0.0427457999625618 no 233 0.04205402189428 179 9659696
SGTC_2836 9010338 19.48 µM 1.72662238455621 0.0428108205004414 no 234 0.042117751554941 318 2994051
SGTC_2702 st077768 96.8 µM 1.71973767222409 0.0434457526221748 no 235 0.0427400683497695 303 6484119
SGTC_1766 st045414 44.774 µM 1.71807350003005 0.0436003637101085 no 236 0.0428916048593681 353 253960
SGTC_2447 5741742 33.78 µM 1.71286846974117 0.0440868088941101 no 237 0.0433683700515869 344 1776504
SGTC_1978 st071761 42 µM 1.70088855648999 0.045223045014695 no 238 0.0444819579362716 303 5147680
SGTC_838 0109-0203 71.4 µM 1.70024248899345 0.0452849847699343 no 239 0.0445426615926582 313 759422
SGTC_2873 9040596 71.43 µM 1.69663074608566 0.0456325078577152 no 240 0.0448832466017536 359 6463863
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.68990574260417 0.0462853005998935 no 241 0.0455229944002052 306 2374 Ca(2+)-ATPase inhibitor.
SGTC_2312 7706453 155.7 µM 1.68901843770649 0.0463719880176722 no 242 0.0456079483305973 346 976098
SGTC_296 1222-0039 74.9 µM 1.68514466498186 0.0467519734794336 no 243 0.0459803320089303 324 5984176
SGTC_159 3970-0959 50 µM 1.68505544665849 0.0467607544085026 no 244 0.0459889372100842 552 6615653
SGTC_1163 k060-0048 49.9 µM 1.68082781225773 0.0471783600562424 no 245 0.0463981823904825 377 6809982
SGTC_3033 9090887 49.47 µM 1.67186459560073 0.0480736341732415 no 246 0.0472755128006186 379 19325384
SGTC_1180 1193-0155 285 µM 1.66685109916512 0.0485802963855792 no 247 0.0477720082751747 340 2921347
SGTC_1836 st055642 81 µM 1.66571580721778 0.0486956193835969 no 248 0.0478850160260497 360 8571
SGTC_2380 9035439 200 µM 1.66257312891112 0.0490159943291142 no 249 0.0481989568372787 379 6462575
SGTC_1286 0929-0070 131 µM 1.65779971676793 0.0495058304093749 no 250 0.0486789492596263 367 1420408
SGTC_2997 9067075 71.4286 µM 1.65385514581506 0.0499135543457773 no 251 0.049078474053313 382 27209819
SGTC_254 nsc-64875 3.808 µM 1.65318494491224 0.0499830939583023 no 252 0.0491466147578299 332 56993
SGTC_1268 0828-0275 2.46 µM 1.65096218665701 0.0502142790832523 no 253 0.0493731481702809 338 745337
SGTC_2223 6903751 107.57 µM 1.64825906782 0.0504965733159559 no 254 0.049649760194623 271 5598863
SGTC_2645 abamectin 100 µM 1.64729022541352 0.0505980594859725 no 255 0.0497492030194669 358 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_422 cantharidin 155 µM 1.64463532936664 0.0508769923818759 no 256 0.0500225183035793 411 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_970 1315-0089 19.5 µM 1.64097093726168 0.0512639959305156 no 257 0.0504017241111019 326 6811083 YLR033W RSC58
SGTC_323 4013-0906 34.3 µM 1.63894937474816 0.0514784973532732 no 258 0.0506119017580081 308 2910086
SGTC_208 k072-0098 12.366 µM 1.63675082783466 0.0517125876066529 no 259 0.050841271949662 437 5948901
SGTC_1845 st056753 3.01 µM 1.63382068549746 0.0520258889719411 no 260 0.0511482537896816 380 5375839
SGTC_1899 st063254 59.6 µM 1.63172894658415 0.0522504663206728 no 261 0.0513682996510792 304 3093813
SGTC_2682 pyrogallin 40.03 µM 1.62792373234117 0.0526609826373969 no 262 0.0517705292600045 396 822798 An ATP competetive kinase inhibitor.
SGTC_1658 st012944 20 µM 1.6258687001202 0.0528837468156188 no 263 0.0519887949131875 390 24207260
SGTC_3346 9158254 43.5805 µM 1.62547250472232 0.0529267799654894 no 264 0.0520309589033175 370 17639500
SGTC_723 4182-0001 115 µM 1.6190869848943 0.0536241876339341 no 265 0.0527142743674073 345 744821 YLR208W SEC13
SGTC_446 go6976 132 µM 1.60829878319049 0.054818960754456 no 266 0.0538848785200484 318 3501 A protein kinase C inhibitor.
SGTC_2908 7930301 100 µM 1.60749280035105 0.0549090599035894 no 267 0.0539731537478473 404 2223178
SGTC_765 1319-0117 244 µM 1.60734642785078 0.0549254351315426 no 268 0.0539891974647783 334 3487746 YGL099W LSG1
SGTC_2137 5261020 140 µM 1.60623688497561 0.0550496892975387 no 269 0.054110935954801 365 763655
SGTC_505 gw-5074 63.9 µM 1.60416565493572 0.0552822339041996 no 270 0.0543387715105557 387 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_947 3447-0010 211 µM 1.60205334000596 0.0555201896188417 no 271 0.0545719073944853 347 748350
SGTC_2824 7998404 51.95 µM 1.59937311726486 0.0558232841214337 no 272 0.0548688609348003 352 837851
SGTC_917 harmaline 728.087 nM 1.58974194963512 0.0569232163949498 no 273 0.0559464918480458 390 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_93 0109-0045 59.227 µM 1.58539497696166 0.0574252215496125 no 274 0.056438310864305 483 88733
SGTC_3343 9148379 18.9835 µM 1.58346203210482 0.0576495612391938 no 275 0.0566580969664681 367 1955036
SGTC_2267 7931562 200 µM 1.58257787420613 0.0577524070352913 no 276 0.0567588549153613 354 934880
SGTC_976 1348-1067 47.6 µM 1.58213545405539 0.0578039237472258 no 277 0.0568093257264366 427 5310671 YGL099W LSG1
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.58126173716635 0.0579057680496701 no 278 0.0569091022268187 478 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1326 1431-2094 10.8 µM 1.5775724003878 0.0583373694860886 no 279 0.0573319385502439 413 616278
SGTC_1710 st031758 61.5 µM 1.57560146044957 0.0585689755057085 no 280 0.0575588396790366 326 5394341
SGTC_2802 7925815 54.55 µM 1.5721457114191 0.0589768039734056 no 281 0.0579583811944801 418 1262923
SGTC_272 doxorubicin 8.13 µM 1.56879648382819 0.0593741841049144 no 282 0.058347683994207 438 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1148 3909-7663 27.7 µM 1.56831142461696 0.0594319091654358 no 283 0.0584042354924276 385 4084526
SGTC_2887 9044784 58.44 µM 1.56448800908946 0.0598884607380742 no 284 0.0588515033884164 395 6465546
SGTC_3050 9093513 49.47 µM 1.56102929743791 0.0603038255760762 no 285 0.0592584192049851 363 25236664
SGTC_2009 4012297 12.05 µM 1.55576497165191 0.0609403544252138 no 286 0.0598819952126129 397 45595307
SGTC_1303 1160-0052 261 µM 1.55556955346639 0.060964083878025 no 287 0.0599052416748026 393 3562476
SGTC_2591 skatole 100 µM 1.55267588632632 0.0613163052747066 no 288 0.0602502929844721 383 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_223 busulfan 5 mM 1.54711637292639 0.0619974769285026 no 289 0.0609175932592419 310 2478 A DNA alkylator.
SGTC_3274 9138298 49.47 µM 1.54462258360741 0.0623049370160027 no 290 0.0612187901739407 426 17015756
SGTC_805 3852-0218 479 µM 1.54255370560445 0.0625609110572898 no 291 0.0614695489047603 407 6615355
SGTC_1371 2421-0008 32.7 µM 1.54160128979023 0.0626790249061171 no 292 0.0615852559741647 416 2827552
SGTC_1560 lithocholic acid 53.1 µM 1.53330884755626 0.063714769294793 no 293 0.0625998878429911 293 9903 A bile acid which acts as a detergent.
SGTC_3187 9109394 49.47 µM 1.53203803716252 0.063874666237719 no 294 0.062756524321699 422 17098090
SGTC_3109 9122853 49.47 µM 1.53135857949038 0.0639602854602701 no 295 0.0628403975588773 390 1234709
SGTC_2405 ticlatone 3.52 µM 1.52556826040075 0.0646935552606678 no 296 0.0635587108409668 415 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_3070 9117005 49.47 µM 1.52432684624771 0.0648516110921903 no 297 0.0637135420402333 306 8779016
SGTC_3290 9121031 71.43 µM 1.52227287323679 0.0651137794316295 no 298 0.0639703610817304 352 17014854
SGTC_1197 1601-0112 267 µM 1.51613363036923 0.065902294467066 no 299 0.0647427830276587 451 7350313
SGTC_1489 4065-0444 182 µM 1.51311503093378 0.0662927027552605 no 300 0.0651252211109109 392 2877968
SGTC_285 1486-1325 46 µM 1.51122151635692 0.0665385116712753 no 301 0.0653660111052394 430 22310230
SGTC_135 0933-0004 26.348 µM 1.5061506325356 0.0672002695838278 no 302 0.0660142546092554 418 21230617 YGL099W LSG1
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.49694614443121 0.0684144563874166 no 303 0.0672036359816989 423 16623 A steroid.
SGTC_1635 st007035 42.4 µM 1.48919857834463 0.0694495174524069 no 304 0.0682175425343138 641 3716403
SGTC_3202 9113761 49.47 µM 1.48513000599355 0.0699978796001418 no 305 0.0687546944383241 519 4798415
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.48359972349554 0.0702049910457719 no 306 0.0689575713999515 445 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1207 2099-0101 141 µM 1.48351284049925 0.0702167640859192 no 307 0.068969103727577 472 5837381
SGTC_2636 apigenin dimethyl ether 100 µM 1.4825319904451 0.0703497790711068 no 308 0.0690993990220381 480 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1683 st010134 710 nM 1.48012564189214 0.0706769293812635 no 309 0.0694198598279448 436 3818134
SGTC_2856 9022925 19.48 µM 1.47814605245126 0.070946935980239 no 310 0.0696843449453064 446 4944862
SGTC_1995 st072814 61.1 µM 1.47268295112315 0.0716961876597519 no 311 0.0704182729008058 402 5769371
SGTC_2729 fluphenazine 10.66 µM 1.47204683203723 0.0717838229897619 no 312 0.0705041157326292 459 3372 An atypical antipsychotic.
SGTC_772 k072-0172 35.3 µM 1.47169173107722 0.0718327794083685 no 313 0.0705520707783867 391 5861980
SGTC_225 nsc-122657 1.016 µM 1.47035687758367 0.072017039651356 no 314 0.0707325619964854 286 275685
SGTC_1127 asiatic acid 681.4 nM 1.46858759778286 0.0722618253437093 no 315 0.070972340390837 448 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_3161 9100388 49.47 µM 1.46740018386542 0.0724264651996184 no 316 0.0711336122561949 412 25236368
SGTC_2860 9025725 38.96 µM 1.46250677812651 0.0731079899993427 no 317 0.0718011941497387 388 40546248
SGTC_2842 9000675 19.48 µM 1.46203545318986 0.0731738916056528 no 318 0.0718657474221885 430 2989072
SGTC_2207 7258803 200 µM 1.45982761158738 0.0734832017777917 no 319 0.0721687289662119 384 3666799
SGTC_1161 k007-0610 110 µM 1.4595215665873 0.0735261563008731 no 320 0.0722108045943255 563 5843850
SGTC_1653 st012112 65 µM 1.45794153128237 0.0737482254719369 no 321 0.0724283298993833 417 720429
SGTC_3285 9112818 20.8695 µM 1.45601212052914 0.0740200931164439 no 322 0.0726946345166912 479 17017947 YPR165W RHO1
SGTC_263 alizarin 107.927 µM 1.4546298414179 0.0742153363525139 no 323 0.0728858824990185 530 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2769 toremifene 3.73 µM 1.45429241075491 0.0742630572073475 no 324 0.0729326268276013 411 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2482 5981709 142.65 µM 1.45239675177841 0.0745315849451977 no 325 0.0731956594855816 490 877755
SGTC_2161 5662504 8.5105 µM 1.45034153393861 0.0748235515266195 no 326 0.0734816511294623 430 2859334
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.44722622555126 0.0752677784907035 no 327 0.0739167868454348 513 6708784 An antioxidant flavonoid
SGTC_1400 3771-8998 51.5 µM 1.44305945199421 0.0758650784054649 no 328 0.0745018621881739 414 670767
SGTC_1704 st028805 70.8 µM 1.4414310715507 0.0760994825101561 no 329 0.0747314687160358 434 2876101
SGTC_1954 st077032 68.9 µM 1.4366242693612 0.0767946338955337 no 330 0.0754123918966879 414 698907
SGTC_2686 alizarin 95.37 µM 1.43490073590372 0.0770450608102573 no 331 0.0756576929915162 430 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1208 2323-2347 50.3 µM 1.4344210569151 0.0771148677549353 no 332 0.0757260710943638 440 5412760
SGTC_1123 mangostin 811.285 nM 1.43286782466655 0.0773412370523589 no 333 0.0759478069295769 478 5281650 An antioxidant.
SGTC_1422 4031-0024 15.5 µM 1.43268863447326 0.0773673848141244 no 334 0.0759734194808325 442 782427
SGTC_3097 9117246 49.47 µM 1.43257286961157 0.0773842810050269 no 335 0.0759899698285374 457 16423892
SGTC_2859 9028643 45.46 µM 1.43157544286143 0.077529974224984 no 336 0.0761326808887892 412 17151580
SGTC_2661 dactinomycin 12.96 µM 1.43097179791221 0.0776182492131809 no 337 0.076219148991158 496 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2869 9037858 32.47 µM 1.43029984969583 0.0777166023664648 no 338 0.0763154889655031 395 27187042
SGTC_780 0109-0199 192 µM 1.42912667764356 0.0778885464567105 no 339 0.0764839135421991 507 610414
SGTC_2084 5306078 60.6385 µM 1.42857592065047 0.077969366785513 no 340 0.0765630795605416 459 679340
SGTC_2283 7944793 200 µM 1.42847549206347 0.0779841109432174 no 341 0.0765775219200101 476 2970533
SGTC_1731 st035964 63 µM 1.42587013980281 0.0783673485767868 no 342 0.0769529150436772 468 6739575
SGTC_2723 salbutamol 83.58 µM 1.42362335398711 0.0786989877178673 no 343 0.0772777658386593 351 9884233 β2-adrenoceptor agonist
SGTC_1088 bifonazole 369 nM 1.42004240149163 0.0792297547214571 no 344 0.0777976685761153 444 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_127 0180-0333 59.125 µM 1.41935328080258 0.0793322060856113 no 345 0.0778980228764841 574 771601
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.41844325419781 0.0794676530810635 no 346 0.0780306974335327 504 1377
SGTC_1429 4049-0205 9.46 µM 1.41636468972187 0.0797776797942703 no 347 0.078334378314748 482 22774478
SGTC_3179 9107801 49.47 µM 1.40482987030865 0.0815147931817134 no 348 0.080035937241672 467 4818259
SGTC_3243 9134147 49.47 µM 1.40243805513228 0.0818785383893684 no 349 0.0803922380681003 456 24282180
SGTC_2291 7917025 104.35 µM 1.39985032160131 0.0822734548973027 no 350 0.0807790725492545 505 2964612
SGTC_2662 daunorubicin 22.37 µM 1.39682823724825 0.0827364720004768 no 351 0.081232614384761 423 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2889 9059656 51.95 µM 1.38795233585826 0.0841076950387608 no 352 0.0825757798135684 516 3949838
SGTC_1215 3852-0577 11.2 µM 1.38780990796735 0.0841298367264701 no 353 0.0825974684901159 540 2884876
SGTC_557 1315-0110 16.2 µM 1.38494892869201 0.0845755287293011 no 354 0.0830340421379675 493 6833801
SGTC_3181 9108277 49.47 µM 1.38353082978644 0.0847970999008018 no 355 0.0832510804685617 466 17097298
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.38131904339738 0.0851435493487367 no 356 0.0835904427076246 462 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_156 3474-0145 5.642 µM 1.38061908517806 0.0852534099507357 no 357 0.0836980560192028 484 2265471
SGTC_812 4251-0442 148 µM 1.38024363328285 0.0853123820289571 no 358 0.0837558217933605 460 5723007
SGTC_130 0136-0219 337.655 µM 1.38015792022162 0.0853258492286444 no 359 0.0837690135164652 491 234244
SGTC_1730 st033808 45.1 µM 1.38002648246073 0.085346503767138 no 360 0.0837892455600525 565 1045166
SGTC_733 4069-0007 56.1 µM 1.37953400804443 0.0854239260354987 no 361 0.0838650841470194 571 5717425 YNL287W SEC21
SGTC_443 clozapine 122 µM 1.37930393654718 0.085460113769698 no 362 0.0839005316650193 395 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_183 3914-0051 30.55 µM 1.37849170001173 0.0855879615259125 no 363 0.0840257643507224 492 1596232
SGTC_87 0100-0052 35.5 µM 1.37732395573087 0.085772017836616 no 364 0.0842060559847046 732 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_574 1315-0397 40 µM 1.37337697475735 0.0863963222825011 no 365 0.0848175919997178 574 6794277
SGTC_2089 5281248 129.67 µM 1.37096694216562 0.0867791906839832 no 366 0.0851926307252014 506 2737878
SGTC_2167 5876490 200 µM 1.3696662210038 0.0869863550576414 no 367 0.0853955588581119 510 686534
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.36791053521214 0.0872665666705819 no 368 0.0856700408323094 485 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1841 st054148 70 µM 1.36471103824029 0.0877789462127185 no 369 0.0861719444645856 459 675442
SGTC_1389 3405-0187 19 µM 1.36416826210843 0.087866090622354 no 370 0.0862573072854082 460 799890
SGTC_1221 2958-7315 257 µM 1.36246752657385 0.0881395668920482 no 371 0.0865251928344899 503 4562705
SGTC_663 1486-0733 13.9 µM 1.35639365529971 0.089121418345079 no 372 0.0874869754531934 568 722445 YPR165W RHO1
SGTC_1748 st037455 53.6035 µM 1.3503720026158 0.0901028408359733 no 373 0.0884483434004575 517 580690
SGTC_2120 5538279 151.968 µM 1.34704198289633 0.0906490112980343 no 374 0.088983355880484 500 2058197
SGTC_1749 st037932 54.2 µM 1.34520675214494 0.0909510635322494 no 375 0.089279238161811 495 594497
SGTC_92 0063-0024 660.874 µM 1.34399659384222 0.0911506460461832 no 376 0.0894747441766344 574 3594437
SGTC_2805 7950783 58.44 µM 1.340051738794 0.0918034969179463 no 377 0.0901142623534803 587 1178958 YDL195W SEC31
SGTC_64 000l-0018 272.079 µM 1.3395806779347 0.0918816856982713 no 378 0.0901908545376082 641 6811119
SGTC_15 0266-0086 27.098 µM 1.33956637443733 0.0918840606278114 no 379 0.0901931809723212 624 1712902 YIL048W NEO1
SGTC_499 genistein 192 µM 1.33886495502452 0.0920005789596095 no 380 0.0903073201087614 447 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2099 5377090 177.372 µM 1.33721710252502 0.0922747471832323 no 381 0.0905758904511894 541 2243829
SGTC_3127 9126946 49.47 µM 1.33720990670705 0.092275945741655 no 382 0.0905770645389928 456 27243249
SGTC_2566 crystal violet carbinol 226 nM 1.33450363062103 0.0927275292120685 no 383 0.0910194288978879 478 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1228 0124-0032 52.5 µM 1.33194167410831 0.0931565347879117 no 384 0.0914396776771067 549 X1228
SGTC_3051 9093778 49.47 µM 1.33112286838044 0.0932939545405458 no 385 0.0915742927296872 432 17217378
SGTC_1092 toremifene 6.32 µM 1.33110251075152 0.0932973730582624 no 386 0.0915776414781997 573 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1977 st070720 65.3 µM 1.32945478487614 0.0935743714015874 no 387 0.0918489868033734 477 682188
SGTC_736 0958-0254 92.6 µM 1.3293617498734 0.0935900295618136 no 388 0.0918643254273796 567 6812352
SGTC_1333 1482-0047 286 µM 1.32763923341016 0.0938802855479744 no 389 0.092148658500547 567 3811116
SGTC_1842 st055362 61.2 µM 1.32475334388881 0.0943680661280013 no 390 0.0926264870045141 565 676032
SGTC_2336 9001819 198.65 µM 1.32351501860145 0.0945779431945152 no 391 0.0928320825815759 570 2989602
SGTC_2162 5663267 200 µM 1.32114473603143 0.0949806288886389 no 392 0.0932265544959097 557 6456493
SGTC_595 3909-8003 73.7 µM 1.31893939784183 0.0953564252298355 no 393 0.093594686742045 526 699517
SGTC_1500 4488-1866 171 µM 1.31845671781774 0.0954388211811077 no 394 0.0936754024456097 581 2900003
SGTC_726 3448-4391 34.2 µM 1.3174714865609 0.0956071678351468 no 395 0.093840316293147 579 1356692
SGTC_1649 st011737 51.3 µM 1.31702482711587 0.095683560567234 no 396 0.093915151357945 517 1761035
SGTC_593 1203-0218 61.7 µM 1.31320173351959 0.0963392671712604 no 397 0.0945574900079645 549 3666956
SGTC_1717 st033143 58.0435 µM 1.31138830557497 0.0966514441086305 no 398 0.0948633038880048 586 674616
SGTC_3078 9116413 49.47 µM 1.30485003878907 0.0977831586264602 no 399 0.0959719582153038 492 17177322
SGTC_2558 carylophyllene oxide 100 µM 1.30483947577884 0.0977849948137605 no 400 0.0959737569974382 586 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2701 st077767 14.721 µM 1.30335720150783 0.0980429119515898 no 401 0.0962264203927076 606 5721188
SGTC_1926 methyl fluorone black 53.6 µM 1.30280812861388 0.0981385775707097 no 402 0.0963201374737958 492 72721 Reacts with homocysteine.
SGTC_781 4335-2806 94.4 µM 1.30042964161701 0.0985537739621038 no 403 0.0967268780666719 625 845254
SGTC_397 arbidol 50 µM 1.29900702889691 0.0988027236478213 no 404 0.0969707584939708 570 131410 A RNA synthesis inhibitor.
SGTC_796 1234-0020 70.7 µM 1.29633253575656 0.0992719909635325 no 405 0.0974304719619872 558 46495034
SGTC_2021 4019055 173 µM 1.29582703813302 0.0993608685303118 no 406 0.0975175403086637 715 44827708 YER133W GLC7
SGTC_2993 9054257 71.4286 µM 1.29445615226496 0.0996021930922397 no 407 0.0977539527879287 572 6470217 YGL055W OLE1
SGTC_198 3454-2873 16.191 µM 1.29320380545054 0.0998230246752655 no 408 0.0979702899281846 543 710957
SGTC_2911 7942208 15.64 µM 1.29283395379428 0.0998883105303651 no 409 0.0980342471566885 490 1243384
SGTC_2166 5933061 31.504 µM 1.29254423287406 0.0999394735643907 no 410 0.0980843690065854 545 2877375
SGTC_815 1582-0027 36.9 µM 1.29227542872162 0.0999869599318751 no 411 0.0981308890350732 553 3128206
SGTC_1254 0550-0035 264 µM 1.29062477013173 0.100278923041469 no 412 0.0984169112537841 585 15121435
SGTC_2082 5219693 150 µM 1.29046523822635 0.100307173466036 no 413 0.0984445868825935 566 2834649
SGTC_3138 9097216 49.47 µM 1.28691342672536 0.10093764471517 no 414 0.0990622324334194 526 25237486
SGTC_1136 pergolide 1.05886 µM 1.28252734689256 0.101720184756837 no 415 0.0998288590576529 643 47811 A dopamine receptor agonist.
SGTC_66 0109-0187 42.4 µM 1.27641566945949 0.102817948213209 no 416 0.100904310008327 525 759417
SGTC_1352 1496-0991 99 µM 1.27635091490753 0.102829625164083 no 417 0.100915749691734 552 3000039
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.27628790050342 0.102840989245563 no 418 0.100926882864494 594 2333 A French combination drug.
SGTC_3143 9086658 49.47 µM 1.27327047718971 0.103386222944816 no 419 0.101461039570348 641 25236626
SGTC_940 3232-1287 54.8 µM 1.26249169645333 0.105351028241131 no 420 0.103385956161296 584 1585493 YIL048W NEO1
SGTC_707 0865-0008 204 µM 1.25791662307425 0.106193109274272 no 421 0.10421095562336 595 723043
SGTC_2921 7974240 10.71 µM 1.2572504458468 0.106316129227217 no 422 0.104331480845923 575 2979074 YDR527W RBA50
SGTC_1684 st024538 14.6195 µM 1.25658253910649 0.106439571851121 no 423 0.104452420355111 576 6732859
SGTC_1245 0418-0076 17.2 µM 1.25566358698527 0.106609581816379 no 424 0.104618983241573 601 6790114
SGTC_173 1273-0061 2.693 µM 1.24913174420795 0.107823650078998 no 425 0.105808445862685 618 2847414 YPL266W DIM1
SGTC_199 4063-0024 41.6 µM 1.24792500976269 0.108049030362881 no 426 0.106029260395536 574 306215
SGTC_324 1315-0088 19.6 µM 1.24765389644988 0.108099712486689 no 427 0.106078915891117 501 6787421
SGTC_830 4076-0286 57.8 µM 1.24628380330501 0.108356100515258 no 428 0.106330110973873 737 6866659
SGTC_584 0986-0246 15.4 µM 1.24307937948091 0.108957458046953 no 429 0.106919291804173 644 53315 YDR232W HEM1
SGTC_387 norethindrone acetate 66.7 µM 1.24302537451594 0.108967613393099 no 430 0.10692924155837 537 541197
SGTC_3213 9129884 49.47 µM 1.24035428766523 0.10947074638223 no 431 0.107422190468598 507 17190742
SGTC_2233 sulbentine 40.3845 µM 1.23904558543771 0.109717865066144 no 432 0.107664308368672 653 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_634 1611-4317 11.2 µM 1.23639015428927 0.11022051299873 no 433 0.108156787049498 641 2843522
SGTC_3074 9116018 49.47 µM 1.23611197543124 0.110273265037138 no 434 0.108208472039049 535 17027303
SGTC_549 1661-1316 519 µM 1.23460320132986 0.110559694628773 no 435 0.108489108494198 606 2857282
SGTC_548 1436-0017 110 µM 1.2309061186733 0.111263811850286 no 436 0.109178989448916 687 9677137
SGTC_179 1273-0063 6.77 µM 1.2295837503311 0.111516437540381 no 437 0.109426509058953 543 3108139
SGTC_1091 telmisartan 47.6 µM 1.22948148789541 0.11153599087462 no 438 0.109445667217223 597 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_213 1246-0773 967 nM 1.22877936059815 0.111670309058153 no 439 0.109577270952244 626 6251622
SGTC_2840 9008771 71.43 µM 1.22802766265171 0.11181423841177 no 440 0.109718291902311 554 2992978
SGTC_1430 4049-0248 69.1 µM 1.22626167813098 0.112152897449366 no 441 0.110050108741492 663 22774488
SGTC_2893 9048488 25.97 µM 1.22263648427676 0.112850388904691 no 442 0.110733513297846 581 6467338
SGTC_132 0417-1715 25.805 µM 1.22257334904541 0.112862563569829 no 443 0.110745442138246 627 6769098
SGTC_2332 7982454 138.89 µM 1.22243064536749 0.112890085249455 no 444 0.110772408121672 622 2981748
SGTC_1103 duloxetine 36.1 µM 1.21878776988565 0.113594269082304 no 445 0.111462377305249 683 60835 A selective serotonin reuptake inhibitor.
SGTC_1167 k781-0610 148 µM 1.21855135955251 0.113640076211095 no 446 0.111507260018223 652 4525169
SGTC_335 4077-0256 27.6 µM 1.21729256126601 0.113884204103162 no 447 0.111746461771513 685 3121989
SGTC_1414 3917-0015 5.4 µM 1.21233210928851 0.114849858003861 no 448 0.112692638709563 574 6618702
SGTC_2694 st077685 81.9 µM 1.21042769332223 0.115222134718267 no 449 0.113057410368538 604 2838096
SGTC_1224 0823-0416 294 µM 1.20999788831815 0.115306271852173 no 450 0.1131398515921 619 3598164
SGTC_321 4534-3890 65.3 µM 1.20955911156336 0.115392210301955 no 451 0.113224057931952 610 699746
SGTC_2994 9053520 71.4286 µM 1.20950184166326 0.115403430494384 no 452 0.11323505198684 610 4647384
SGTC_6 0844-0013 19.835 µM 1.20723143611225 0.115848868134414 no 453 0.113671513565493 851 1584900
SGTC_3024 9090631 49.47 µM 1.2060854484274 0.116074165943834 no 454 0.11389227250718 573 25236383
SGTC_1630 st005209 31.3 µM 1.20206224796055 0.116867577266068 no 455 0.114669705809123 706 3367314
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.20087293917701 0.117102854091378 no 456 0.114900246381724 652 5393153
SGTC_3325 9138760 55.175 µM 1.20050797789661 0.117175120360394 no 457 0.114971058060921 613 43844959
SGTC_207 4185-0010 4.486 µM 1.19883688224307 0.117506418828257 no 458 0.115295689114724 703 3761753
SGTC_590 k048-0076 22.4 µM 1.19703861654606 0.117863669258846 no 459 0.115645751743368 619 6832814
SGTC_1493 4348-0038 111 µM 1.19680763326874 0.117909612927748 no 460 0.115690771179009 682 800424
SGTC_995 3931-2021 34.6 µM 1.19477621333516 0.118314217757278 no 461 0.116087238128111 596 730143
SGTC_1893 st059353 36.1 µM 1.19459762540869 0.118349834605517 no 462 0.116122138731388 620 3112488
SGTC_779 1360-0071 233 µM 1.19410625207937 0.118447871216197 no 463 0.116218203955444 685 7566
SGTC_959 1222-0044 107 µM 1.19261606872692 0.118745536892939 no 464 0.116509884892389 624 6083612
SGTC_1757 st041620 31.8375 µM 1.19234372715276 0.118799994470222 no 465 0.116563247719414 635 5289815
SGTC_1294 1000-1494 117 µM 1.18972493064127 0.119324551052123 no 466 0.117077261638262 604 712797 YDL207W GLE1
SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.18726748825603 0.119818272291468 no 467 0.117561063941043 632 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2656 pseudo-anisatin 100 µM 1.18557138773002 0.120159872460121 no 468 0.117895803589617 609 6708809 A neurotoxin.
SGTC_797 k781-0471 270 µM 1.18482385892648 0.120310644868362 no 469 0.118043548559471 661 23738129
SGTC_1258 0671-0043 57.1 µM 1.18088120159357 0.12110806201198 no 470 0.118824960056647 639 4298767
SGTC_1187 1391-0724 117 µM 1.17508067767594 0.122287986292798 no 471 0.119981220113077 679 6997986
SGTC_2638 epoxomicin 18 µM 1.17197154144726 0.122923748320423 no 472 0.120604241022326 679 9915668 A protesome inhibitor.
SGTC_3037 9091026 49.47 µM 1.16960070329805 0.123410096593177 no 473 0.121080847093225 747 25236398 YIL048W NEO1
SGTC_2431 5490079 200 µM 1.16902221190436 0.123528971291764 no 474 0.121197341178209 651 5722345
SGTC_3169 9102970 49.47 µM 1.16809413550652 0.123719850011844 no 475 0.1213843978132 633 17027839
SGTC_169 k015-0017 16.025 µM 1.16549322607998 0.124255882519189 no 476 0.121909700301142 587 1840002
SGTC_1029 k015-0030 64.7 µM 1.15962175967386 0.125471924989087 no 477 0.123101418852251 639 2208316
SGTC_1923 st058458 19.1 µM 1.15897274152951 0.125606851532835 no 478 0.123233648093034 710 3534982
SGTC_20 0481-0013 4.944 µM 1.15824724629584 0.125757796952608 no 479 0.12338157635176 636 182045
SGTC_612 0302-0167 22.4 µM 1.15643162988602 0.126136105732611 no 480 0.123752325074044 726 235821
SGTC_1943 st076331 65.2 µM 1.15352453043537 0.126743490785261 no 481 0.124347577471079 689 24208415
SGTC_935 2996-0153 430 µM 1.15264638865096 0.126927362232871 no 482 0.124527777319704 659 23738523
SGTC_2453 5731132 22.18 µM 1.15119523598284 0.127231621487243 no 483 0.124825962343692 708 1362040
SGTC_1427 4048-4900 550 nM 1.14926802474444 0.127636478509435 no 484 0.125222739338839 658 24132586
SGTC_1329 1447-1697 50.6 µM 1.14815642537374 0.127870403502531 no 485 0.125451997045405 661 2840515
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.14728833041916 0.128053292475243 no 486 0.125631237683829 638 803109
SGTC_3269 9137823 49.47 µM 1.14629531683378 0.128262721840008 no 487 0.125836490009969 588 17682936
SGTC_1817 st052116 64.4 µM 1.14111839388065 0.129358401072552 no 488 0.126910328905409 646 4361398
SGTC_1165 k072-0275 30.3 µM 1.14086673505614 0.129411828683553 no 489 0.126962692089499 657 6153523 YGL055W OLE1
SGTC_2936 9038235 15.59 µM 1.14024414733353 0.129544070852869 no 490 0.127092299848726 646 4749415
SGTC_763 3453-1109 128 µM 1.13781348413544 0.130061257497395 no 491 0.127599186615316 701 1560353
SGTC_2119 5528445 120.635 µM 1.13238317854473 0.131221853479264 no 492 0.128736686898591 668 791935
SGTC_2727 riluzole 51.77 µM 1.13228149405708 0.131243654077176 no 493 0.128758053904835 623 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_232 clozapine 119 µM 1.13106184184162 0.131505335778114 no 494 0.129014531709657 665 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_88 0180-0332 8.668 µM 1.13105198466154 0.131507452145222 no 495 0.129016605995099 679 3101745
SGTC_756 0508-1999 28.3 µM 1.13084029725297 0.131552907761818 no 496 0.129061157796077 660 6753853
SGTC_2092 5303694 80.6725 µM 1.12970990009597 0.131795821399573 no 497 0.129299242116534 699 1963699
SGTC_737 1950-0117 57.9 µM 1.12651651517302 0.132483726473842 no 498 0.129973477049627 674 5393513
SGTC_2184 6075246 200 µM 1.12566228054558 0.132668160648908 no 499 0.130154247627987 680 2267320
SGTC_613 3914-0030 117 µM 1.12535155136034 0.132735292715256 no 500 0.130220046342691 433 1145395
SGTC_731 3966-0296 387 µM 1.12319619396335 0.133201594895728 no 501 0.130677089344247 680 660956
SGTC_2125 5246583 200 µM 1.12152795201183 0.133563284806983 no 502 0.131031600144881 782 835267
SGTC_2011 4012611 177 µM 1.12000687213757 0.133893656793234 no 503 0.131355416807877 685 2049887
SGTC_2709 st078560 56 µM 1.11930404235789 0.13404649793598 no 504 0.131505225939631 696 17250903
SGTC_1037 k284-1091 78.7 µM 1.1184695679777 0.134228122822812 no 505 0.131683248391166 637 3334711
SGTC_3320 9137005 35.139 µM 1.11787709992554 0.134357177145722 no 506 0.131809743370615 653 4908713
SGTC_578 3460-0051 92 µM 1.11739535388002 0.134462176240207 no 507 0.131912660407862 777 2876744
SGTC_1035 k081-0041 55.2 µM 1.11537300124086 0.134903573230081 no 508 0.132345307115973 722 731709
SGTC_2892 9047358 58.44 µM 1.11129585746426 0.135796466400228 no 509 0.13322051096049 638 6466771
SGTC_2968 9090663 33.37 µM 1.11126950847022 0.135802249953444 no 510 0.133226179984459 691 25236811
SGTC_2247 cerulenin 830 nM 1.10969607809885 0.136147920705772 no 511 0.133565006742485 697 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_3272 9137413 49.47 µM 1.10840454370518 0.136432110695926 no 512 0.133843571743709 669 17614870
SGTC_2340 7987427 183.45 µM 1.10657642288735 0.136835064729328 no 513 0.134238552780561 688 2239331
SGTC_983 1491-0821 12.2 µM 1.10649870703725 0.136852212849551 no 514 0.134255361672073 700 46495113
SGTC_2913 7966556 36.57 µM 1.10569161718122 0.137030385287775 no 515 0.134430009795576 668 2976516
SGTC_1723 st034307 2.5525 µM 1.10531488583393 0.137113606400528 no 516 0.13451158497772 692 867466
SGTC_1783 st039459 87.517 µM 1.10454093644371 0.13728468251472 no 517 0.134679278008792 768 729761
SGTC_3349 9149703 23.001 µM 1.10199727907418 0.137847966827272 no 518 0.135231427262503 670 4910494
SGTC_1018 4259-0013 28.1 µM 1.10040516361881 0.138201336660519 no 519 0.135577814838607 679 6801262
SGTC_2969 9091408 28.7 µM 1.09791125391625 0.138756100090945 no 520 0.136121621649366 679 4286311
SGTC_233 rapamycin 362 pM 1.09732928035019 0.138885776495896 no 521 0.136248737816705 740 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_466 geldanamycin 89.2 µM 1.09627270936277 0.13912141440981 no 522 0.136479724322189 579 5288382 HSP90 inhibitor.
SGTC_1381 2324-0066 62.1 µM 1.09594003928401 0.139195663241432 no 523 0.136552507737689 667 10885928
SGTC_655 k060-0012 42 µM 1.09056266247574 0.140399584547518 no 524 0.137732683191433 702 5994525
SGTC_369 0957-0393 4.5 µM 1.09053947290826 0.140404791639942 no 525 0.137737787643694 649 6997992
SGTC_1450 4112-4260 37.6 µM 1.08806002238627 0.140962295524339 no 526 0.138284305398541 747 1633175
SGTC_2240 6690706 185.951 µM 1.08649565338172 0.141314815060602 no 527 0.138629881459572 612 805876
SGTC_1060 3448-7350 82 µM 1.0857620041383 0.141480343415385 no 528 0.138792150321146 728 570178
SGTC_42 0133-0086 60.653 µM 1.0810561218948 0.142545223719719 no 529 0.139836074953464 644 162923 Model of phenazepam hydroxylation.
SGTC_728 3030-5151 22.5 µM 1.08103442259317 0.142550146512669 no 530 0.139840900925168 682 3125388
SGTC_382 3229-0966 23.2 µM 1.08060949423603 0.142646570680646 no 531 0.139935428727749 760 5722370
SGTC_2216 7189485 200 µM 1.07966623104391 0.142860772261314 no 532 0.140145418308996 748 731273
SGTC_2508 celastrol 40.54 µM 1.0794143116247 0.142918016323104 no 533 0.14020153689954 667 122724 Celastrol is a natural product and antioxidant.
SGTC_1676 st018489 23.4 µM 1.07840836196473 0.143146754430993 no 534 0.140425778478226 721 3696235
SGTC_2646 retinol 96.75 µM 1.07818351687983 0.143197914681813 no 535 0.140475933169464 705 445354 A vitamin A analog and teratogen.
SGTC_94 0334-0113 514.748 µM 1.07684550109123 0.143502616251742 no 536 0.140774646920679 716 6795178
SGTC_264 promethazine 12.5 mM 1.07609578734356 0.143673537082571 no 537 0.140942209754881 854 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2808 7946468 45.46 µM 1.07202406800084 0.144604212186868 no 538 0.141854610987115 762 2970879
SGTC_3057 9095946 49.47 µM 1.06910616896891 0.145273650614894 no 539 0.14251091611111 749 24540043
SGTC_155 k072-0202 43.6 µM 1.06817536135948 0.145487638945351 no 540 0.14272070831509 705 5857737
SGTC_2814 7977482 42.97 µM 1.06599376009469 0.145990009218002 no 541 0.143213231322813 804 6456762
SGTC_72 0744-0168 198.391 µM 1.06575240420232 0.146045659191556 no 542 0.143267790794456 711 677577
SGTC_420 mitomycin C 81.9 mM 1.06273500000349 0.146742591687117 no 543 0.143951071929165 735 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2344 7990960 76.95 µM 1.06226331253421 0.146851739093852 no 544 0.144058082311867 704 140813
SGTC_325 2810-4341 181 µM 1.06140986748353 0.1470493627107 no 545 0.144251837250519 749 774970
SGTC_12 0849-0099 9.267 µM 1.05992086752976 0.14739458213333 no 546 0.144590300652766 735 6071388
SGTC_752 1896-0090 130 µM 1.0593439708345 0.147528479461655 no 547 0.144721578263837 757 772567
SGTC_1087 pterostilbene 9.05 µM 1.05577895602008 0.148357724298229 no 548 0.145534607356636 772 5281727 Similar to reservatol, lowers cholesterol.
SGTC_359 0081-0058 15.9 µM 1.05363382678329 0.148858194371473 no 549 0.146025297954433 688 3494159
SGTC_833 3852-0053 558 µM 1.05089827183125 0.149498048790137 no 550 0.14665265710387 814 3123681
SGTC_449 xestospongin c 11.1929 µM 1.04957844397428 0.149807415953357 no 551 0.146955986025225 776 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2520 obtusaquinone 4.71 µM 1.0476303267268 0.150264833724658 no 552 0.147404479698545 758 5967872
SGTC_3099 9120367 49.47 µM 1.04687171181113 0.150443207984372 no 553 0.147579375156376 756 24824940
SGTC_1298 1079-1278 263 µM 1.04553199538296 0.15075856191459 no 554 0.14788858048941 783 2840950
SGTC_1827 berberine 7.24 µM 1.04354994308373 0.151225921049039 no 555 0.14834683130437 687 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_639 0833-0042 114 µM 1.04315852880598 0.151318328632705 no 556 0.148437438530593 787 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_588 3970-1144 52.9 µM 1.0416246798671 0.15168081136794 no 557 0.148792860897663 770 1888707
SGTC_1860 st056228 74.6 µM 1.04080089262315 0.151875728692931 no 558 0.148983982852929 732 688679
SGTC_1438 4092-1045 4 µM 1.03994669953359 0.152078016046466 no 559 0.14918233221285 778 1351342
SGTC_37 0566-0070 1.56 µM 1.03863221208581 0.152389658273287 no 560 0.14948790936212 822 1626686
SGTC_635 k038-0028 24.7 µM 1.03683118857129 0.152817337549971 no 561 0.149907268774234 792 4035102
SGTC_1506 4226-2149 212 µM 1.03593165333895 0.153031243077499 no 562 0.150117014604557 822 991114
SGTC_3148 9097893 49.47 µM 1.03459769925544 0.153348816737405 no 563 0.150428414462386 700 17174100
SGTC_502 l-744,832 89.3 µM 1.02572601008325 0.155471995584131 no 564 0.152510375297711 786 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1082 camptothecin 424.86 nM 1.02461512752625 0.155739212607853 no 565 0.152772411899796 674 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1772 st048439 82.2 µM 1.02250095426344 0.15624860218235 no 566 0.153271930615823 776 2927068 YDL195W SEC31
SGTC_2714 st079313 56.9 µM 1.01889065333455 0.15712100392383 no 567 0.154127440746616 769 2939799
SGTC_1284 0929-0043 16 µM 1.01752432573777 0.15745200056499 no 568 0.154452033086804 793 1239883
SGTC_2135 5326629 150.42 µM 1.01454553197985 0.15817520911701 no 569 0.155161257295437 713 5020077
SGTC_1044 1222-0021 1.78 µM 1.00903088239498 0.15951983216791 no 570 0.156479911824867 786 4306703
SGTC_1579 chlormadinone acetate 49.4 µM 1.00764145038506 0.15985979045147 no 571 0.156813311125479 825 45114258 A steroidal progestin.
SGTC_2279 7948423 32.93 µM 1.00634258275562 0.160178018230336 no 572 0.157125401596391 739 1247112
SGTC_2611 pyromycin 23.93 µM 1.00441254594033 0.160651649334579 no 573 0.157589902638622 770 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.00333646643489 0.160916116026635 no 574 0.157849273538429 823 688669
SGTC_2411 st077133 39.94 µM 1.00231541712191 0.161167320633762 no 575 0.158095639393781 845 1403142 YNL221C POP1
SGTC_2228 7354201 200 µM 1.00227430947423 0.161177439535956 no 576 0.158105563414458 819 753451
SGTC_632 0781-2353 4.65 µM 1.00221030645607 0.161193195100525 no 577 0.15812101554489 809 6811515 YHR007C ERG11
SGTC_1355 1499-0035 1.68 µM 1.00200249134731 0.161244359683963 no 578 0.158171194796848 777 1548538
SGTC_1941 st076221 61.8 µM 1.00191071673164 0.161266958188758 no 579 0.158193358117292 839 2828568
SGTC_2285 7945142 200 µM 1.00045013244276 0.161626889313002 no 580 0.158546359572112 750 2970608
SGTC_2072 5231554 129 µM 0.997853310376937 0.162268115131234 no 581 0.159175247508421 860 789545
SGTC_1681 tripelennamine 100 µM 0.996651900517006 0.162565335407498 no 582 0.159466752204686 742 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2572 astragaloside iv 100 µM 0.996355695852433 0.162638668736557 no 583 0.159538675643729 788 45006101 An anti-inflammatory agent.
SGTC_3240 9133527 49.47 µM 0.993520995342227 0.163341562373784 no 584 0.160228062010292 781 17617455
SGTC_2059 5238311 157 µM 0.992350198729253 0.16363244864401 no 585 0.160513361816214 769 703021
SGTC_57 miconazole 162.5 nM 0.991958183693854 0.163729920513207 no 586 0.160608962186352 774 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1618 st003135 44.5 µM 0.989293901170057 0.164393374516693 no 587 0.161259683565658 798 1270615
SGTC_1056 3448-1962 115 µM 0.988015316327307 0.164712383023634 no 588 0.161572573553199 773 715507
SGTC_47 0149-0135 24.25 µM 0.986411404716975 0.165113127678793 no 589 0.161965635425597 824 5239155
SGTC_2003 4023581 200 µM 0.98436217792994 0.165626053928691 no 590 0.162468733797513 795 16641307
SGTC_34 0469-0683 81.75 µM 0.982603108505009 0.166067174122893 no 591 0.162901406959243 821 3690923
SGTC_3122 9126309 49.47 µM 0.978753395215963 0.16703520896645 no 592 0.163850921154569 865 17591206
SGTC_2825 7998094 58.44 µM 0.977971471080755 0.167232272470561 no 593 0.164044217148706 774 2987815
SGTC_1441 4106-0040 13 µM 0.977616652229957 0.167321744682484 no 594 0.164131979116034 829 2904180
SGTC_1773 st048542 73.5835 µM 0.977413227504358 0.167373054797896 no 595 0.164182308534966 800 3237138
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.97658184573576 0.167582860821989 no 596 0.164388105169511 863 5106787 A p450 inhibitor.
SGTC_556 4058-0063 51.5 µM 0.975633414286659 0.167822412065348 no 597 0.164623079887692 864 6615692
SGTC_1826 st055655 41.6 µM 0.97552231194065 0.167850488296122 no 598 0.164650619824421 832 676168
SGTC_2597 laccaic acid a 100 µM 0.974901858325763 0.168007336248371 no 599 0.164804472117755 823 5491415 A textile dye.
SGTC_2523 spermine 47.74 µM 0.973304874797491 0.168411480383585 no 600 0.165200900187249 819 1103 A DNA binding polyamine.
SGTC_1195 1502-0147 41.1 µM 0.972658752004974 0.168575170353618 no 601 0.165361466051616 863 817940
SGTC_2545 solidagenone 89.61 µM 0.971856925752988 0.168778448702073 no 602 0.16556086563211 605 6708572 An anti ulcer agent
SGTC_729 4092-0585 94.1 µM 0.967937401787149 0.169774388996122 no 603 0.166537816793857 778 2169061
SGTC_565 1418-0001 44.5 µM 0.96694606242994 0.170026881564491 no 604 0.166785499031936 887 2862145
SGTC_1093 fluphenazine 7.97 µM 0.966649375149107 0.170102494118523 no 605 0.166859671364906 854 6602611 An atypical antipsychotic.
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.96490521715518 0.170547438998789 no 606 0.167296144033581 797 689007
SGTC_2474 5321570 43.32 µM 0.964092252413294 0.170755085440809 no 607 0.167499838325506 846 2841384
SGTC_1548 st061468 90.8 µM 0.963454436657029 0.170918108769672 no 608 0.167659759557524 868 390799
SGTC_740 k014-0057 261 µM 0.962956558179117 0.171045433833925 no 609 0.167784662262984 919 4012779
SGTC_2539 epi(13)torulosol 80 µM 0.956590297705552 0.172678856076978 no 610 0.169387043925524 805 6708597
SGTC_1393 3470-5649 58.2 µM 0.954614086015996 0.173187918216622 no 611 0.16988644557514 737 4108395
SGTC_3235 9132602 49.47 µM 0.95456402624256 0.173200825760456 no 612 0.169899108255256 867 4912240
SGTC_732 3970-1727 52.7 µM 0.953950462947983 0.173359078303825 no 613 0.170054358989376 865 1275699
SGTC_2485 5633444 17.78 µM 0.953686631560903 0.173427154975887 no 614 0.170121144541381 808 5724239
SGTC_1837 st055472 66.5 µM 0.95040618735206 0.174275032020095 no 615 0.170952950643794 871 676091
SGTC_866 0495-0101 262 µM 0.950146905333776 0.174342159248476 no 616 0.17101880628238 796 635694
SGTC_537 1334-0398 209 µM 0.94957726218105 0.174489695596449 no 617 0.17116354824563 892 5846986
SGTC_3242 9133940 49.47 µM 0.94841156962194 0.174791854545694 no 618 0.171459985899046 890 17248444
SGTC_2569 tetrandrine 100 µM 0.946496748803279 0.175288915282581 no 619 0.171947639875262 758 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2265 7929201 200 µM 0.944418301636749 0.175829464538121 no 620 0.172477966357454 912 1265108
SGTC_2274 7947094 46.08 µM 0.942930886643133 0.176216949364686 no 621 0.172858127634336 930 2971028
SGTC_1784 st039334 36.3 µM 0.942633981136747 0.176294360544921 no 622 0.172934076176595 848 3496984
SGTC_1385 3091-4834 14.1 µM 0.94186191954762 0.17649575829527 no 623 0.17313166934059 812 4072814
SGTC_1732 st034308 51.822 µM 0.941643565406501 0.176552743913039 no 624 0.173187578632931 813 830119
SGTC_2351 9026858 72.31 µM 0.941642397914558 0.176553048633973 no 625 0.173187877598617 796 1409300
SGTC_331 k048-0133 24.5 µM 0.939588317463217 0.177089688427391 no 626 0.173714385521055 814 6813582
SGTC_2652 actinonin 100 µM 0.937984347899621 0.177509449988022 no 627 0.174126226943299 839 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_310 1273-0058 1.06 µM 0.936023211027146 0.178023535437032 no 628 0.174630618581844 986 2734232
SGTC_464 bw-b 70c 158 µM 0.935333227052353 0.178204628398533 no 629 0.174808298367266 909 5353454
SGTC_3021 9087658 49.47 µM 0.932238376467763 0.179018329471753 no 630 0.175606673327026 877 25237042
SGTC_2091 4-phenylthiadiazole 200 µM 0.927949971013747 0.180149698368757 no 631 0.176716760728397 886 270010
SGTC_1335 1486-0900 202 µM 0.927443880437401 0.180283510858303 no 632 0.176848058305791 892 X1335
SGTC_1955 wogonin 32.4 µM 0.926123109295904 0.180633022039943 no 633 0.17719100282293 878 5281703 A flavanone.
SGTC_3029 9088683 49.47 µM 0.9260467139331 0.180653251276321 no 634 0.177210852085038 877 25236615
SGTC_247 mechlorethamine 29.705 µM 0.923171949685343 0.181415511530326 no 635 0.177958802105132 839 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2949 9072542 2.23 µM 0.922155914207696 0.181685400070931 no 636 0.17822362747873 879 16457352
SGTC_1597 7-benzyloxygramine 47.5 µM 0.920747258566568 0.182059995288451 no 637 0.178591198304708 969 260807
SGTC_1206 3978-0017 132 µM 0.920075090634782 0.182238910866865 no 638 0.178766760137867 836 3873677
SGTC_1227 3909-8010 46.6 µM 0.918646280022537 0.182619592145653 no 639 0.179140308341777 856 15982272
SGTC_1534 6-azauridine 81.6 µM 0.913815669492065 0.183910296475241 no 640 0.180406855689766 967 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_185 k048-0037 25.491 µM 0.91370310847414 0.183940439541407 no 641 0.180436435108676 925 6827589
SGTC_2206 7254556 146.969 µM 0.91184393420395 0.184438758601929 no 642 0.180925439475485 900 4398905
SGTC_1648 st011736 69.8 µM 0.911142796777969 0.184626904058653 no 643 0.181110069747601 879 2855514
SGTC_1711 st032263 62.8 µM 0.909564449961801 0.18505087920191 no 644 0.181526126988286 870 3958979
SGTC_831 k061-1017 217 µM 0.905737662162255 0.186081338483036 no 645 0.182537361523135 1033 1240153
SGTC_1481 3346-2004 36 µM 0.90480081775937 0.186334148463953 no 646 0.182785459186222 931 2770522
SGTC_1986 st071812 45 µM 0.89996340502848 0.18764292064996 no 647 0.184069862889254 879 11838594
SGTC_1280 0880-0253 10.1 µM 0.89871242528578 0.18798229788945 no 648 0.184402928476392 910 6836607
SGTC_1474 0330-0125 5.35 µM 0.897259652551119 0.18837689460166 no 649 0.184790190383604 934 X1474
SGTC_2185 6113692 200 µM 0.897256282080444 0.188377810669985 no 650 0.184791089428719 837 874150
SGTC_2719 novobiocin 32.65 µM 0.893694043392611 0.189347535796546 no 651 0.185742806645628 875 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1767 st044992 70.3 µM 0.892703521363513 0.189617724217802 no 652 0.186007982055852 912 9600693
SGTC_416 estradiol valerate 100 µM 0.892141612277381 0.189771103657595 no 653 0.186158516588938 906 13791 A steroid.
SGTC_2467 5474540 200 µM 0.892077310522916 0.189788660412506 no 654 0.186175747737996 930 5413519
SGTC_2219 9098279 200 µM 0.891783728741815 0.189868831776835 no 655 0.1862544323557 919 902349
SGTC_725 1497-0963 19 µM 0.890526146567229 0.190212488114921 no 656 0.186591717648774 952 3549977
SGTC_2104 5389443 200 µM 0.889091933214765 0.190604878115224 no 657 0.186976836956569 944 2244536
SGTC_971 1315-0384 26.7 µM 0.888652514120774 0.1907251992515 no 658 0.187094929450442 904 6769120
SGTC_1906 st060206 94.7 µM 0.888135464450005 0.190866836764335 no 659 0.18723394398172 977 5133468
SGTC_126 0417-1624 672.48 µM 0.880714993474325 0.192906658713197 no 660 0.189236049734922 1083 41912 YDL195W SEC31
SGTC_1935 st074532 41.6 µM 0.878902799761559 0.193406830417785 no 661 0.189726990252496 1010 2829742
SGTC_1758 st042942 75.2445 µM 0.877745013421348 0.193726797277339 no 662 0.190041055307222 934 669317
SGTC_458 nppb 133 µM 0.877250456016561 0.193863571916203 no 663 0.190175307968713 918 4549 A chloride channel blocker.
SGTC_1700 st030840 7.9285 µM 0.877123534349519 0.193898682820553 no 664 0.190209771546691 958 5499307
SGTC_1459 k035-0031 35.7 µM 0.874582384617224 0.194602467664607 no 665 0.190900587962127 825 3877128 YMR208W ERG12
SGTC_1334 1486-0610 236 µM 0.871586585927767 0.195434163507809 no 666 0.191716975583168 933 3742339
SGTC_2231 micatex 6.853 µM 0.87140863590359 0.195483633961862 no 667 0.191765536069967 968 20737 An antifungal of unknown mechanism.
SGTC_2213 7173844 200 µM 0.870992500665024 0.195599350054196 no 668 0.191879123920394 977 892728
SGTC_2853 9015042 58.44 µM 0.87077318464745 0.195660352711573 no 669 0.191939004766879 917 6457456
SGTC_573 3702-0553 84.7 µM 0.870384836019886 0.195768400047313 no 670 0.192045065408309 910 1222756
SGTC_1351 1496-0003 46.5 µM 0.868762762214118 0.196220088907727 no 671 0.192488452365183 980 3891978
SGTC_637 1181-0519 7.26 µM 0.867268419679455 0.196636767956072 no 672 0.192897477874367 1005 6252091 YGR060W ERG25
SGTC_2784 7567673 72.73 µM 0.865344885992653 0.197173910027015 no 673 0.193424760689277 982 3471247
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.864937920102042 0.197287667936596 no 674 0.193536431574047 1101 688664
SGTC_1366 1683-0113 21.9 µM 0.863771530165808 0.197613925169034 no 675 0.193856705177154 948 708623
SGTC_662 k832-1615 104 µM 0.860006385353882 0.198669317622842 no 676 0.194892761336596 925 5878478
SGTC_279 1273-0055 2.93 µM 0.857241467592228 0.199446500680964 no 677 0.195655724712826 1042 2847562
SGTC_3355 9151058 44.0485 µM 0.854785203826454 0.200138457871936 no 678 0.196335035451251 987 17015728
SGTC_1482 3346-2049 8.48 µM 0.853567856335761 0.200481932497376 no 679 0.196672237486089 961 3826804
SGTC_978 1416-0512 87.4 µM 0.853354584940218 0.200542143450938 no 680 0.19673134919061 990 6814003
SGTC_1616 st002734 56.1 µM 0.852684122451531 0.200731499681257 no 681 0.196917249063073 984 4026101
SGTC_2925 9010536 32.5 µM 0.852407159257801 0.200809752680696 no 682 0.196994073982083 1004 2994177
SGTC_3072 9116419 49.47 µM 0.851734669327947 0.200999833724827 no 683 0.197180686837193 935 17170162
SGTC_2330 7979373 200 µM 0.850487608348763 0.201352604315326 no 684 0.197527023462916 938 1863007
SGTC_1328 1441-0025 69.2 µM 0.849868819967058 0.20152778582975 no 685 0.197699011222222 925 4562601
SGTC_2950 9072895 21.46 µM 0.84843391859512 0.201934363511284 no 686 0.198098179794414 1008 17332245
SGTC_2531 methyl deoxycholate 70.07 µM 0.847021988854929 0.202334911115887 no 687 0.198491432632693 940 16667744 Haematoxylin.
SGTC_1932 st074806 40.9 µM 0.842661409649679 0.203574951770937 no 688 0.199708917790749 1094 17251235
SGTC_3008 9078912 71.4286 µM 0.841254367525636 0.203976044857221 no 689 0.200102724378714 960 16648731
SGTC_1997 st073024 93.8 µM 0.840905829925055 0.204075472113751 no 690 0.200200346070056 997 686268
SGTC_2094 5332512 191.667 µM 0.839314935227426 0.204529672868322 no 691 0.200646302184103 1024 755774
SGTC_2066 5222451 176 µM 0.835354015689979 0.205663126429254 no 692 0.201759206349991 1059 2281147
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.835150732613765 0.205721398156508 no 693 0.201816422584248 1062 66535 A nucleotide analog.
SGTC_2045 5106652 78.05 µM 0.833810069667846 0.206105948701712 no 694 0.202194010027824 1015 673349
SGTC_1166 k206-0078 225 µM 0.833638806769896 0.206155103768458 no 695 0.202242275335634 1016 5404595
SGTC_333 3486-0131 40.1 µM 0.8327277689977 0.206416702321735 no 696 0.202499139812736 1039 6744690
SGTC_1080 nisoldipine 24.4 µM 0.832280221626305 0.206545284641453 no 697 0.202625395915171 1008 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1337 1486-1011 40.3 µM 0.831919066201335 0.206649080759289 no 698 0.202727314566815 1043 X1337
SGTC_658 3253-0951 102 µM 0.83156442501157 0.206751034737896 no 699 0.202827424693288 1049 1184878
SGTC_3053 9095903 49.47 µM 0.831047167791882 0.206899791749199 no 700 0.202973491934824 1045 17174018
SGTC_1531 st059297 52.4 µM 0.830762916266788 0.206981566063412 no 701 0.203053787899714 1005 7566702
SGTC_973 1325-0077 65.9 µM 0.830507163813489 0.207055158023435 no 702 0.203126049594427 1048 2835149
SGTC_2404 5161160 200 µM 0.826527729071851 0.208202220882512 no 703 0.204252397509143 1006 2831543
SGTC_480 am 92016 50 µM 0.823925816570597 0.208954239290766 no 704 0.204990855188811 962 2129 K+ channel blocker.
SGTC_1983 st071813 46.9 µM 0.823152180654921 0.209178147817501 no 705 0.205210729173943 986 11838595
SGTC_1016 4226-1401 38 µM 0.822050161662497 0.209497341972545 no 706 0.205524174307164 1039 2901613
SGTC_496 calpeptin 138 µM 0.820991918521397 0.209804126203843 no 707 0.20582543574138 959 73364 A calpain inhibitor.
SGTC_3280 9140961 49.47 µM 0.817689805593208 0.210763103535756 no 708 0.206767166502195 961 4901226
SGTC_652 0437-0092 114 µM 0.817318194419825 0.210871185059594 no 709 0.206873305883111 1001 3091274
SGTC_3289 9119912 71.43 µM 0.816584160825022 0.211084771078722 no 710 0.207083054896811 1008 17014829
SGTC_1571 st070080 73.4 µM 0.815553057632434 0.21138501122016 no 711 0.207377903505382 1007 4315245
SGTC_424 splitomicin 100 mM 0.815496530691113 0.21140147815635 no 712 0.207394074812136 935 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1105 epirubicin 18.1 µM 0.814603409396466 0.211661754167644 no 713 0.207649679133404 1001 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_503 tyrphostin 8 294 µM 0.813631593647701 0.211945176518146 no 714 0.207928016528154 1014 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_967 1306-0166 352 µM 0.810946176683706 0.212729510356731 no 715 0.208698290328751 1022 4437607
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.805761771327429 0.214248512209181 no 716 0.210190112273599 1025 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1765 st044815 90.4 µM 0.804667991981576 0.214569787621195 no 717 0.210505647463993 1017 645695
SGTC_3315 9136395 68.55 µM 0.804567631403705 0.21459928051795 no 718 0.210534613559764 1075 16876844
SGTC_3141 9094609 49.47 µM 0.803148456364212 0.215016584729833 no 719 0.210944466569843 949 25236309 YDL196W YDL196W
SGTC_2299 7976368 114.88 µM 0.80199758800527 0.215355339893756 no 720 0.211277176739742 1022 2979718
SGTC_1137 ixabepilone 100 µM 0.800983168252462 0.215654188361433 no 721 0.21157069507085 1016 154225 A novel microtubule stabilizer.
SGTC_2388 9080168 200 µM 0.798872854099023 0.216276657576841 no 722 0.212182070421079 978 15943073
SGTC_1299 1079-1439 3.74 µM 0.798776705800948 0.216305042731368 no 723 0.212209949950953 1036 323161
SGTC_2627 acetyl isogambogic acid 100 µM 0.796743945845491 0.216905664085545 no 724 0.21279987787575 1028 6857789 A caspase activator and apoptosis inducer.
SGTC_3172 9105863 49.47 µM 0.796126810971658 0.217088200057484 no 725 0.212979166046029 1025 2348785
SGTC_389 tpck 16.7 µM 0.79504286634499 0.217409023645061 no 726 0.213294283654497 1023 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1457 k015-0032 57.3 µM 0.794678438029291 0.217516947807319 no 727 0.213400289008672 1016 4302660
SGTC_937 3122-0005 46.7 µM 0.793528715429342 0.217857636712332 no 728 0.213734922934627 1075 759535
SGTC_2065 5221596 34.26 µM 0.792349608545519 0.21820735228371 no 729 0.214078426585738 1009 788581
SGTC_3012 9080433 71.4286 µM 0.789932138700837 0.21892536903339 no 730 0.214783700450636 1100 17688859
SGTC_1473 k844-0725 134 µM 0.789779172002714 0.218970847601414 no 731 0.214828372397902 1152 54682906
SGTC_125 0133-0007 11.75 µM 0.78713897313374 0.219756661670912 no 732 0.215600258516839 1148 26541
SGTC_788 1182-0090 188 µM 0.786564314604472 0.219927914116535 no 733 0.2157684780227 1131 5715185
SGTC_873 0591-4978 488 µM 0.783874407153096 0.220730543715889 no 734 0.216556904135635 1119 3305145
SGTC_1289 0976-0073 69.1 µM 0.782600455064391 0.22111125729984 no 735 0.216930887094691 1070 3391136
SGTC_2252 omeprazole 400 µM 0.779667150291909 0.221989286390774 no 736 0.217793409644517 994 4594 A proton pump inhibitor.
SGTC_1390 3413-2614 145 µM 0.778818137151081 0.222243793348672 no 737 0.218043426058166 1130 3421432
SGTC_2540 epiandrosterone 100 µM 0.777861143768354 0.222530868828823 no 738 0.218325438624278 1186 441302 A steroid.
SGTC_1300 1094-0077 113 µM 0.777690303800015 0.222582139029511 no 739 0.218375804868274 1007 5532636
SGTC_1244 0416-0015 52.5 µM 0.777031503180814 0.222779912485394 no 740 0.218570092055449 1053 96201
SGTC_546 peri-Naphthalide 147 µM 0.776865146461183 0.222829868985331 no 741 0.218619168123953 1047 223824 A penicillin ester.
SGTC_1747 st037496 66.6 µM 0.776317890116491 0.2229942537026 no 742 0.218780656247058 1084 723305
SGTC_2157 5649910 96.377 µM 0.773366056537829 0.223882114803608 no 743 0.219652886192664 1061 2858091
SGTC_542 3381-0244 89.3 µM 0.772342573609023 0.224190429388739 no 744 0.219955778184322 1112 1112843
SGTC_913 3487-1245 167 µM 0.771745915022384 0.224370278357577 no 745 0.220132465284282 1057 4016153
SGTC_1696 st025591 34.7925 µM 0.77151664230624 0.224439409104007 no 746 0.220200380917437 1107 2787147
SGTC_76 0433-0009 400.328 µM 0.77147360881878 0.224452385990412 no 747 0.220213129724367 955 2841569
SGTC_2432 5630864 12.22 µM 0.771034442595971 0.224584842318992 no 748 0.220343258306964 1046 5714970
SGTC_1509 1326-1131 80 µM 0.770457134945 0.224759030739209 no 749 0.2205143863799 1047 768313
SGTC_908 3448-7491 47.7 µM 0.769481031507575 0.225053720205141 no 750 0.220803900427019 1120 1203031
SGTC_1814 st052110 31.539 µM 0.76917312982369 0.225146722338151 no 751 0.220895269761254 1083 674163
SGTC_19 0279-0214 38.434 µM 0.769095979757611 0.225170029034009 no 752 0.220918167311308 1169 3566274 YBR002C RER2
SGTC_266 formosanin C 406 nM 0.768513772892343 0.22534595523658 no 753 0.221091005670064 1090 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1278 0874-0585 172 µM 0.767019385058386 0.225797872431718 no 754 0.221534995028674 1090 766306
SGTC_1276 0871-0068 94.2 µM 0.766946295116281 0.225819988671097 no 755 0.221556723444622 1062 3414906
SGTC_3276 9139060 49.47 µM 0.766908583434232 0.225831400304256 no 756 0.221567934972607 1135 4870619
SGTC_1925 st057770 10.1 µM 0.766781661009308 0.225869809689014 no 757 0.221605670869673 1043 5989122
SGTC_529 4076-0302 30.3 µM 0.763337628358265 0.226913455264134 no 758 0.22263103335979 1031 5816522
SGTC_1682 st012968 530 nM 0.763203729616036 0.22695408546676 no 759 0.222670952434042 1034 24207270
SGTC_2740 felodipine 17.08 µM 0.763029835373369 0.227006858018273 no 760 0.222722801409153 1049 3333 L-type calcium channel blocker
SGTC_2048 5246248 200 µM 0.762821873034259 0.227069978469328 no 761 0.222784817292663 1095 677046
SGTC_1387 3342-1166 1.8 µM 0.762629048386892 0.22712851318845 no 762 0.222842327796985 1032 3418228
SGTC_979 1426-2828 121 µM 0.761182701487207 0.227567843864117 no 763 0.223273974495448 1130 747872
SGTC_811 0416-0114 265 µM 0.76064644242642 0.227730855112353 no 764 0.223434136100251 1092 6612453
SGTC_694 1315-0438 43.2 µM 0.759981461140694 0.227933086407031 no 765 0.223632833230114 1010 6793154
SGTC_3167 9103034 49.47 µM 0.758252170606925 0.228459463631441 no 766 0.224150017251115 1112 5127859
SGTC_619 1652-1634 108 µM 0.756948557894451 0.228856720217324 no 767 0.224540341179276 1040 5400454
SGTC_755 1995-0008 37.3 µM 0.75488550006759 0.22948619797961 no 768 0.22515884332223 1131 689533
SGTC_2342 7990637 118.86 µM 0.754669231502675 0.229552241726839 no 769 0.225223736209433 1129 2033102 YER133W GLC7
SGTC_3039 9090270 49.47 µM 0.752627934450646 0.230176134098225 no 770 0.225836763217065 1118 17173750
SGTC_3171 9103192 49.47 µM 0.751007424569477 0.230672093718959 no 771 0.226324093760977 1172 13018434
SGTC_1144 3486-0183 12.5 µM 0.750650855667378 0.230781302279599 no 772 0.226431403215701 1117 6744069
SGTC_3016 9080866 49.47 µM 0.750209197336608 0.230916611733214 no 773 0.226564360170373 1135 17066299
SGTC_854 0422-0053 192 µM 0.749922205756615 0.231004560165655 no 774 0.226650779818972 1132 3596728
SGTC_2391 6285546 200 µM 0.748718516571363 0.231373633739588 no 775 0.22701344040758 1107 846083
SGTC_2493 resveratrol 26.09 µM 0.748620869001483 0.231403588721268 no 776 0.22704287507322 1049 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_222 nsc-310342 10.666 µM 0.744098023047176 0.232793412882481 no 777 0.228408587626563 1075 432556
SGTC_2452 5863136 48.41 µM 0.742518321954592 0.2332799295298 no 778 0.228886677544112 1123 2184096
SGTC_2238 6671620 73.2395 µM 0.741747732398004 0.233517460459473 no 779 0.229120096893914 1132 729941
SGTC_3011 9081274 71.4286 µM 0.741630577225833 0.233553584782928 no 780 0.229155596066165 1142 6625322
SGTC_3083 9117465 49.47 µM 0.740945000814386 0.233765041615556 no 781 0.229363394309684 1137 16420915
SGTC_1444 4112-3581 28 µM 0.740654962756179 0.233854531889904 no 782 0.22945133664404 1133 2877249
SGTC_2029 5175081 200 µM 0.740164016120833 0.23400605508966 no 783 0.229600239451246 1159 1380876
SGTC_2718 lomofungin 53.02 µM 0.739379565291918 0.234248276716287 no 784 0.229838273612008 1134 5351222 A RNA synthesis inhibitor.
SGTC_1374 2889-5571 141 µM 0.739322296518914 0.234265965522284 no 785 0.22985565668765 1119 2853281
SGTC_2289 7946404 165.07 µM 0.738178419110542 0.234619433768314 no 786 0.230203017624133 1186 1246120 YPR165W RHO1
SGTC_2952 9073731 13.78 µM 0.738153872557144 0.234627022101844 no 787 0.230210474885894 1184 16457353
SGTC_1152 3909-8331 15.9 µM 0.737068603738044 0.234962658263046 no 788 0.230540315407545 1112 16001939
SGTC_1847 st056231 15 µM 0.734666550376724 0.23570647293248 no 789 0.231271298279757 1172 5393180
SGTC_2311 7694451 200 µM 0.73462361047803 0.235719781412693 no 790 0.23128437732308 1085 2163142
SGTC_1159 4092-0538 61.2 µM 0.733805307768701 0.235973479386234 no 791 0.231533702592377 1182 717301
SGTC_3196 9111891 49.47 µM 0.730616448366509 0.236963554138179 no 792 0.232506731180274 1178 18891510
SGTC_3277 9138724 49.47 µM 0.728827284339915 0.237520050876818 no 793 0.23305365972836 1029 15943418
SGTC_2449 5812982 45.77 µM 0.72796204143074 0.23778943080037 no 794 0.233318411412857 1097 776185
SGTC_2765 myclobutanil 7.74 µM 0.727878419383761 0.237815474101177 no 795 0.233344007378344 1139 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1945 st075991 56.6 µM 0.727857639716051 0.237821945976092 no 796 0.233350368091658 1089 1084980
SGTC_1573 oleylamine 1.06 µM 0.727305399370141 0.237993977881168 no 797 0.233519445625153 1163 5356789 An amine of the fatty acid oleic acid.
SGTC_1304 1165-0502 251 µM 0.725434749459335 0.238577222531156 no 798 0.234092680680166 1147 767425
SGTC_789 1309-1135 70.6 µM 0.723961460163543 0.239037125389808 no 799 0.234544698023144 1163 3092424
SGTC_2749 bexarotene 57.39 µM 0.723731421260531 0.23910897818921 no 800 0.234615319412856 1149 82146 An retinoic acid receptor inhibitor.
SGTC_651 3253-0966 34.4 µM 0.723600427701499 0.239149899386191 no 801 0.234655539374698 1184 781462
SGTC_1864 st057645 30.4 µM 0.723285803390804 0.239248200794677 no 802 0.234752156475906 1186 688666
SGTC_622 1348-1566 26.3 µM 0.721561611072341 0.239787300272465 no 803 0.235282024200852 1188 7340407
SGTC_2241 6772625 37.8075 µM 0.72069139874797 0.240059639129259 no 804 0.23554970278998 1129 2285411
SGTC_1928 4'-methoxychalcone 40.3 µM 0.7206883167644 0.240060603956532 no 805 0.235550651111135 1186 641818
SGTC_2592 piperlongumine 83.33 µM 0.720304040777232 0.240180919653553 no 806 0.235668908688326 1120 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1236 0330-0013 258 µM 0.718995512520737 0.240590862438966 no 807 0.236071842314149 1146 4617066
SGTC_558 k064-0027 21.3 µM 0.716370911985662 0.241414258468165 no 808 0.236881175529202 1162 5088526
SGTC_685 1278-0033 54.9 µM 0.71626931275571 0.241446163171012 no 809 0.236912535747949 1187 3590572
SGTC_1218 1348-1416 30.7 µM 0.714710851242317 0.241935846011196 no 810 0.237393865597478 1173 6787668
SGTC_3047 9092122 49.47 µM 0.713902288024204 0.242190116064898 no 811 0.237643801222191 1149 17173831
SGTC_1261 0712-0010 12.7 µM 0.713582479797895 0.242290726590191 no 812 0.237742697232066 1176 2840123
SGTC_2990 9074105 71.4286 µM 0.712417807877853 0.242657319589683 no 813 0.238103045706969 1137 6502001
SGTC_451 chloral hydrate 100 µM 0.711537541683923 0.242934591966664 no 814 0.238375597783127 1230 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_623 k072-0108 16.9 µM 0.711282276983605 0.243015029067645 no 815 0.238454665960352 1139 5382803
SGTC_1581 himbacine 57.9 µM 0.710996164839691 0.243105203703542 no 816 0.238543306190098 1158 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_3017 9080681 49.47 µM 0.709960155182487 0.243431876626774 no 817 0.238864422560203 1155 16451914
SGTC_2300 7976697 71.57 µM 0.708936977253452 0.243754736106241 no 818 0.239181793577347 1090 2236109
SGTC_2347 9049783 174.81 µM 0.706749824770659 0.244445657304631 no 819 0.239860980219497 1173 6467988 YPL169C MEX67
SGTC_2179 6298986 200 µM 0.706520773857813 0.244518075449735 no 820 0.239932169271904 1125 738374
SGTC_2160 5660466 132.927 µM 0.70639462249259 0.244557965176056 no 821 0.239971382052295 1129 2859134
SGTC_2421 5690543 90.72 µM 0.703873661013944 0.245355840885287 no 822 0.240755727779407 1179 3397993
SGTC_3249 9135183 49.47 µM 0.703697353639229 0.245411693865575 no 823 0.240810634368707 1226 4902779
SGTC_2703 st077852 53.4 µM 0.701488353592755 0.246112068832943 no 824 0.241499150143218 1168 6281836
SGTC_1323 1348-1351 11.2 µM 0.700980188515889 0.246273336760961 no 825 0.241657689529942 1133 6989654
SGTC_1339 1486-1321 22.7 µM 0.700547052021327 0.246410838822856 no 826 0.241792865788436 1204 3469382
SGTC_3082 9117008 49.47 µM 0.700438290685431 0.246445372294129 no 827 0.241826815229077 1203 41448529
SGTC_1857 st056007 79.3 µM 0.699959782374771 0.246597337170094 no 828 0.24197621051151 1193 619834
SGTC_1031 k035-0009 16 µM 0.698926695712891 0.246925596367387 no 829 0.242298921574404 1217 5180959
SGTC_3329 9141233 27.5565 µM 0.698337667668533 0.247112862320458 no 830 0.242483023913324 1184 4909101 YNL103W MET4
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.697859623091215 0.247264899829251 no 831 0.242632493746651 1204 688664
SGTC_2497 7-hydroxyflavone 100 µM 0.69755513252276 0.24736176621161 no 832 0.242727724581525 1150 5281894
SGTC_1762 st045503 25.4615 µM 0.697505848738631 0.247377446574289 no 833 0.242743140215362 1220 4645554
SGTC_1446 4239-0190 62 µM 0.695565941696337 0.247995078418791 no 834 0.243350350761236 1206 1340085
SGTC_1054 3429-0080 167 µM 0.695423626091864 0.248040421546127 no 835 0.243394929281171 1212 1162877
SGTC_1744 st037937 38.9 µM 0.694931957723042 0.248197105872233 no 836 0.243548971978986 1242 1016152
SGTC_878 0828-0289 13.7 µM 0.694449367359344 0.24835094854515 no 837 0.243700221675287 1192 745350 YLR208W SEC13
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.694084113849729 0.248467419750832 no 838 0.243814730279913 1183 61125 An anti-inflammatory.
SGTC_2083 5306046 65.942 µM 0.6926109436562 0.248937476205092 no 839 0.244276870325408 1219 539837
SGTC_328 k915-0120 63.5 µM 0.69259567883302 0.248942349353147 no 840 0.244281661438852 1177 6624543
SGTC_1359 1582-0056 520 nM 0.692239856871513 0.249055956476767 no 841 0.244393356308922 1217 3661189
SGTC_2052 5265182 7.135 µM 0.691255174230038 0.249370490477505 no 842 0.244702598119992 1193 1239884
SGTC_2461 5755302 26.15 µM 0.690963066807747 0.249463838002912 no 843 0.244794375620574 1191 2788904
SGTC_118 0083-0097 135.343 µM 0.688652531850458 0.25020285970811 no 844 0.245520977212084 1282 5207356
SGTC_3063 1327-0034 4 µM 0.688609405473669 0.250216664654943 no 845 0.245534550313018 1141 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2070 5230947 200 µM 0.68840429497074 0.250282326976421 no 846 0.245599109956203 1283 2835538
SGTC_351 caspofungin 25 nM 0.688213483399898 0.25034341996221 no 847 0.245659177118242 1262 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2794 7785382 27.27 µM 0.687341729642611 0.250622633757088 no 848 0.245933704066336 1205 2205081
SGTC_3153 9100258 49.47 µM 0.686043143219733 0.251038863368783 no 849 0.246342951425498 1170 25236848
SGTC_1991 st073000 8.92 µM 0.685750378612319 0.251132752287015 no 850 0.246435266105923 1268 4301969 YIL048W NEO1
SGTC_1734 st037168 69.4 µM 0.684538365232497 0.251521639645313 no 851 0.246817635918156 1198 708907
SGTC_2806 7952793 58.44 µM 0.683808583406507 0.251755951275086 no 852 0.247048022895315 1218 2972490
SGTC_392 N-ethylmaleimide 8.33 µM 0.683447018156021 0.251872082000126 no 853 0.247162209101502 1179 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_3304 9125678 46.087 µM 0.682470489914754 0.252185873241153 no 854 0.247470748265965 1210 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2979 9012552 45.46 µM 0.682179876948504 0.252279296716338 no 855 0.247562608663451 1262 17100905
SGTC_861 0443-0273 110 µM 0.680133405529483 0.252937693108787 no 856 0.248209997124855 1223 6149169
SGTC_1854 st056233 32.9 µM 0.679977218543352 0.252987979128911 no 857 0.248259442957038 1176 5393174
SGTC_2589 lobaric acid 100 µM 0.679497826312621 0.253142357276374 no 858 0.248411242222725 1213 73157 A novel microtubule depolymerizer.
SGTC_1515 3460-0031 42.1 µM 0.677361720647962 0.253830846831612 no 859 0.249088239704171 1192 2876596
SGTC_306 1672-3436 11.6 µM 0.677177521253664 0.253890262256108 no 860 0.24914666408203 1239 6797378
SGTC_1614 st002383 48.6 µM 0.676884184671357 0.253984896078127 no 861 0.249239719645528 1233 1947235
SGTC_1354 1498-1681 81 µM 0.676462237012148 0.254121053794684 no 862 0.249373607082143 1270 5754243
SGTC_2816 7982706 58.44 µM 0.676333882884621 0.254162479806713 no 863 0.24941434247687 1222 2981853
SGTC_2358 9037157 4 µM 0.675820625803136 0.25432816778983 no 864 0.249577268798986 1236 2388925
SGTC_432 NS 1619 61.3 µM 0.675673839731838 0.254375563202002 no 865 0.249623874391014 1229 4552 A K+/calcium channel activator.
SGTC_764 1951-2361 146 µM 0.674873042048895 0.254634212394183 no 866 0.249878214574711 1207 5438930
SGTC_2555 cholic acid 100 µM 0.674648331677115 0.254706816211275 no 867 0.249949609215664 1234 6708657 Influences liver metabolism.
SGTC_1386 3228-0095 33.8 µM 0.671919048640838 0.255589510946745 no 868 0.250817616462065 1227 870181
SGTC_2807 7945238 51.95 µM 0.670990658571558 0.255890131239661 no 869 0.251113240236808 1256 17148797
SGTC_27 0485-0001 32.618 µM 0.670984092244567 0.255892258126985 no 870 0.25111533178396 1177 2054479
SGTC_3295 9122362 53.5725 µM 0.670691862521899 0.255986923078557 no 871 0.251208423935871 1231 4730473
SGTC_1688 st021091 57.6 µM 0.669763762998184 0.25628769292755 no 872 0.251504198559884 1243 3656366
SGTC_2407 paclitaxel 400 µM 0.669603737221436 0.256339571203734 no 873 0.251555215524174 1301 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2118 5526350 200 µM 0.669467746634501 0.25638366188535 no 874 0.251598574254786 1237 743594
SGTC_881 0833-0569 170 µM 0.66820611914003 0.25679289334876 no 875 0.252001014987255 1221 5418700
SGTC_1746 st038117 42 µM 0.66804612097138 0.256844815901624 no 876 0.252052076323383 1242 2898218
SGTC_1078 idebenone 36.1 µM 0.667486079589457 0.257026603370664 no 877 0.252230849235762 1250 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_974 1326-0144 138 µM 0.666715740256936 0.257276762114146 no 878 0.252476861342824 1266 5411856
SGTC_3027 9089541 49.47 µM 0.666603563559595 0.257313200745964 no 879 0.252512696132626 1234 9943819
SGTC_2063 5246145 200 µM 0.66654803611107 0.257331238855724 no 880 0.252530435339806 1272 711240
SGTC_602 3130-1533 38.1 µM 0.666274006417816 0.257420267114053 no 881 0.252617988496193 1256 720941
SGTC_902 1120-0002 2.07 µM 0.665779200355716 0.257581062928315 no 882 0.252776120734608 1235 3280475
SGTC_3287 9117173 37.0625 µM 0.663364948152636 0.258366363555899 no 883 0.253548424678029 1225 2789709
SGTC_1661 st013063 9.66 µM 0.663325946326996 0.258379060125894 no 884 0.253560911281308 1289 721395
SGTC_3067 9117431 49.47 µM 0.661191672051448 0.259074339714771 no 885 0.254244700660583 1242 17150885
SGTC_2189 6047310 154.431 µM 0.659079253080115 0.259763450922927 no 886 0.254922438773476 1196 711535
SGTC_909 3448-9333 149 µM 0.65243738953262 0.261936299082367 no 887 0.257059525395645 1231 3344074
SGTC_475 α-linolenic acid 10 µM 0.65201975104415 0.262073237921478 no 888 0.257194215498717 1348 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2022 5136654 200 µM 0.651632749254283 0.262200164087423 no 889 0.25731905788738 1263 1713771
SGTC_1112 tnp00069 1.16933 µM 0.650895521364561 0.262442042099462 no 890 0.257556966358321 1315 145826
SGTC_175 3793-3120 23.7 µM 0.650710983621216 0.262502605188227 no 891 0.257616535819283 1265 5322297
SGTC_2154 5570129 200 µM 0.649500223481853 0.262900139617805 no 892 0.258007551021407 1274 673366
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.648885451125849 0.263102108405803 no 893 0.258206209633442 1295 279621
SGTC_1050 3232-1156 69.3 µM 0.648569161394409 0.263206048729049 no 894 0.258308446932293 1245 700529
SGTC_2762 leflunomide 42.06 µM 0.64832414852723 0.263286580196007 no 895 0.258387659158757 1280 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_278 4092-0821 23.9 µM 0.646850814190826 0.263771104760059 no 896 0.258864250791559 1268 877900
SGTC_1568 digitonin 820 nM 0.646388762597374 0.263923149858298 no 897 0.259013808068863 1296 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1454 4239-0054 42.6 µM 0.645901781533883 0.26408344671852 no 898 0.259171482893924 1370 1340767
SGTC_2953 9074162 66.49 µM 0.644608935859276 0.264509246081843 no 899 0.259590321310248 1246 16451992
SGTC_1480 1070-0044 41.2 µM 0.643653963037765 0.264823991025751 no 900 0.25989992456778 1289 3124987
SGTC_1445 4239-0156 97.7 µM 0.642956494324302 0.265053986662374 no 901 0.260126165002392 1356 4008346
SGTC_2691 st077356 60.2 µM 0.642875926768914 0.265080560965592 no 902 0.260152305529417 1323 2839272
SGTC_403 arphamenine a 50 µM 0.641013572744928 0.265695214503741 no 903 0.260756932337623 1238 5487158 An arginine aminopeptidase inhibitor.
SGTC_2580 diallyl disulphide 81.36 µM 0.640543579268834 0.265850445825812 no 904 0.260909633325804 1297 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2218 6965428 192.983 µM 0.640306196924859 0.265928866880406 no 905 0.26098677638068 1261 675684
SGTC_734 2023-0417 80 µM 0.638131656333097 0.266647787856558 no 906 0.261693990609619 1269 3935732
SGTC_2960 9079389 5.97 µM 0.637434183588213 0.266878586022905 no 907 0.261921034049836 1284 16457355
SGTC_214 4373-3496 70 µM 0.636180351957916 0.267293740522022 no 908 0.262329438966793 1356 3779166
SGTC_561 1550-0330 72.9 µM 0.634678488249724 0.267791449153853 no 909 0.262819063199451 1251 6812934
SGTC_1107 amlodipine 47 µM 0.634551891698504 0.267833423819643 no 910 0.262860356427407 1186 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1670 st016595 4.04 µM 0.633989199118922 0.268020031659162 no 911 0.263043935472045 1279 597879
SGTC_2783 7738165 71.43 µM 0.633491902094298 0.268185006598058 no 912 0.263206233674746 1227 17201110
SGTC_1608 st001473 40.5 µM 0.630782283018158 0.269084801280294 no 913 0.264091444620077 1256 7292267
SGTC_1679 SEC14.276 6.7 µM 0.630254837630196 0.269260128292005 no 914 0.264263933015693 1323 1005053 YMR079W SEC14
SGTC_509 pifithrin 175 µM 0.628954626029837 0.269692573460301 no 915 0.264689380987375 1364 4817 A p53 inhibitor.
SGTC_2789 5281112 71.43 µM 0.627154216900859 0.270291956135326 no 916 0.265279075376863 1285 765948
SGTC_1455 4262-0120 131 µM 0.627129600774751 0.270300155818616 no 917 0.265287142603347 1369 1529587
SGTC_1413 3910-0535 34.4 µM 0.627091229502009 0.27031293761814 no 918 0.265299717931412 1329 2876951
SGTC_1055 3448-0672 86 µM 0.626697131638246 0.270444232477632 no 919 0.265428892220372 1297 748378
SGTC_1511 0906-3109 28.5 µM 0.626594491522361 0.270478432563412 no 920 0.265462540025562 1333 2882180
SGTC_334 1502-1024 68.5 µM 0.626297922995211 0.270577262491398 no 921 0.265559774210959 1321 3296216
SGTC_2263 7948595 193.29 µM 0.625381442270942 0.270882788912158 no 922 0.265860369506356 1306 2971371
SGTC_2053 5265679 138 µM 0.625184423125104 0.270948491498573 no 923 0.265925012065482 1276 764595
SGTC_604 1000-0114 314 µM 0.62514774573951 0.270960723670411 no 924 0.265937046902382 1355 1572745
SGTC_448 monastrol 171 µM 0.624873808296324 0.271052092490411 no 925 0.266026941873381 1282 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2315 7733312 200 µM 0.624487722982237 0.271180893085788 no 926 0.266153665278578 1282 726316
SGTC_251 melphalan 456.522 µM 0.623801734645897 0.271409818550752 no 927 0.266378900156307 1364 460612 A DNA alkylator.
SGTC_1785 bathophenanthroline 24 µM 0.620749965624969 0.272429409028814 no 928 0.267382074224545 1284 72812 An iron chelator.
SGTC_2881 9058953 51.95 µM 0.62028675458745 0.272584333113838 no 929 0.267534506850056 1271 17122249
SGTC_1122 capsaicin 818.572 nM 0.618969075310125 0.273025278936945 no 930 0.267968365760786 1398 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2456 5770359 74.46 µM 0.61737195849064 0.273560208835876 no 931 0.268494706766236 1353 3118787
SGTC_3006 9075424 71.4286 µM 0.616771833053821 0.273761345671852 no 932 0.26869261655013 1277 7465181
SGTC_1451 4152-0210 104 µM 0.616601735220863 0.273818368620621 no 933 0.268748724860174 1356 659563
SGTC_3260 9137109 49.47 µM 0.61635258506555 0.273901903369136 no 934 0.268830919917369 1217 17478346
SGTC_608 k048-0125 159 µM 0.615302481942931 0.274254119002831 no 935 0.269177489395671 1356 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_749 1000-0129 128 µM 0.614598127347062 0.274490492199513 no 936 0.269410075717316 1401 708470
SGTC_2704 st078022 71.1 µM 0.613309517207793 0.274923194772718 no 937 0.269835850820834 1364 54697681
SGTC_2787 5284540 71.43 µM 0.612681595388761 0.275134166456696 no 938 0.270043447124748 1345 736958
SGTC_3200 9114385 49.47 µM 0.612004344436948 0.275361801268867 no 939 0.270267441599401 1290 17018030 YLR208W SEC13
SGTC_257 daunorubicin 18.5 µM 0.611798549425125 0.2754309905992 no 940 0.270335524790805 1394 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.611365279884098 0.275576685977219 no 941 0.27047889143203 1364 364106
SGTC_3237 9133362 49.47 µM 0.611308240227886 0.275595869502677 no 942 0.270497768387646 1331 43845137
SGTC_2361 9034121 116 µM 0.611274540037354 0.27560720382878 no 943 0.270508921586796 1317 6496917
SGTC_1944 st076371 56.9 µM 0.609774466976679 0.276111952814453 no 944 0.271005608769221 1300 24208455
SGTC_2586 curcumin 80 µM 0.609748370531629 0.276120737837297 no 945 0.271014253552699 1363 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_869 0564-0080 44.1 µM 0.609676895858814 0.276144799542468 no 946 0.27103793116279 1303 6843321
SGTC_459 nigericin 15.3 µM 0.609438490601205 0.276225065301661 no 947 0.271116915783843 1369 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1516 st013856 110 µM 0.608328178553052 0.276599033482288 no 948 0.271484917777673 1312 5281404 A mutagen and neurotoxin.
SGTC_706 4262-0057 46.9 µM 0.606638869213783 0.277168491405564 no 949 0.272045299571026 1289 883298
SGTC_2403 6032726 181.2 µM 0.606078501426948 0.277357515261835 no 950 0.2722313130914 1331 2881040
SGTC_3241 9133421 49.47 µM 0.605991079764148 0.277387010112704 no 951 0.272260338322596 1334 17018221
SGTC_1252 0493-0875 34.8 µM 0.605042185842516 0.277707252319815 no 952 0.272575483451686 1336 3960963
SGTC_3045 9092950 49.47 µM 0.604476191488829 0.277898355691795 no 953 0.27276354677317 1420 44120432
SGTC_77 0828-0286 12.516 µM 0.604432018022623 0.277913273201926 no 954 0.272778227027987 1294 745345
SGTC_1885 st057546 99.9 µM 0.603957522515589 0.278073536380438 no 955 0.272935941766658 1394 702008
SGTC_1478 0453-0656 35.7 µM 0.603054443223027 0.278378680332603 no 956 0.273236235789015 1345 5258496
SGTC_1712 st032288 53.4 µM 0.602964109918606 0.27840921227786 no 957 0.273266282631645 1308 2883011
SGTC_7 0192-1582 4.227 µM 0.601959123108704 0.278748999924528 no 958 0.273600673688244 1380 252616
SGTC_1667 st014849 34.6 µM 0.597823209945771 0.280149479748661 no 959 0.274978951071291 1361 5348460
SGTC_1192 1488-0095 21.4 µM 0.5967098611175 0.280527057316722 no 960 0.275350553852435 1343 915875
SGTC_660 4031-1742 102 µM 0.594797912859244 0.281176043406441 no 961 0.275989281440212 1281 6738706
SGTC_3246 9135460 32.98 µM 0.594129799362314 0.281402996721098 no 962 0.276212650611958 1325 41446951
SGTC_203 k066-0004 30.888 µM 0.592354139314707 0.282006604903971 no 963 0.276806734690171 1408 6795412
SGTC_1079 idarubicin 2.36 µM 0.590933241929323 0.282490065712931 no 964 0.277282575895499 1340 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_539 4859-0462 2.54 µM 0.590636527596017 0.28259107314349 no 965 0.277381992376981 1350 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1938 st074717 56.4 µM 0.590573236164347 0.282612621045642 no 966 0.277403200926143 1277 17250979
SGTC_1861 st057647 17.4 µM 0.590461649897095 0.282650613103118 no 967 0.277440594693049 1448 688668
SGTC_1052 3253-3998 198 µM 0.589715462663665 0.282904732418441 no 968 0.277690713429624 1321 5450317
SGTC_189 3970-0742 2.116 µM 0.589574960453405 0.282952593706159 no 969 0.27773782148194 1378 2891807
SGTC_217 ketoconazole 989 nM 0.58942752665116 0.283002820381346 no 970 0.277787257777623 1310 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2961 9083290 32.55 µM 0.589347761416119 0.283029996005375 no 971 0.277814005794297 1381 17741490
SGTC_3117 9124945 49.47 µM 0.587319282073491 0.283721509580584 no 972 0.278494646716769 1264 17592065
SGTC_2970 9090938 41.86 µM 0.585646219087372 0.284292469049878 no 973 0.279056641029868 1393 17217104
SGTC_487 nimodipine 119 µM 0.583164608228763 0.285140368481612 no 974 0.279891246917141 1283 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2934 9036370 36.88 µM 0.583122166656372 0.285154880098393 no 975 0.27990553122703 1397 6462800
SGTC_575 k072-0246 11.9 µM 0.583087682865429 0.285166671050781 no 976 0.279917137493626 1375 6796779
SGTC_2047 4141938 200 µM 0.582801507444018 0.285264531228227 no 977 0.280013465032583 1377 3807862
SGTC_2524 avocatin b 10.57 µM 0.581753724999863 0.285622966026487 no 978 0.280366288936696 1331 6710748
SGTC_2885 9057732 51.95 µM 0.58158133416556 0.285681959551533 no 979 0.280424359396649 1352 6471414
SGTC_601 0986-0029 62.9 µM 0.581308605721089 0.285775301249414 no 980 0.280516240825543 1366 24747981
SGTC_2757 clomiphene 4.22 µM 0.580695699315081 0.285985122250308 no 981 0.280722780381476 1451 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1805 st050013 60.3 µM 0.58049263827225 0.286054653855227 no 982 0.280791224889059 1360 4037144
SGTC_3035 9091303 49.47 µM 0.580387983119698 0.286090492721939 no 983 0.280826503493478 1382 25237002
SGTC_3219 9131112 49.47 µM 0.579781165584118 0.286298337738643 no 984 0.281031100156869 1320 17612988 YMR079W SEC14
SGTC_1960 st011366 51.8 µM 0.57975134405751 0.286308553951404 no 985 0.281041156740562 1369 3972846
SGTC_3015 9080845 49.47 µM 0.577193135954468 0.287185584533832 no 986 0.281904496709279 1447 5296973
SGTC_2054 5233173 129 µM 0.576985513057681 0.287256819657208 no 987 0.281974620972657 1414 6889
SGTC_2986 9022445 71.43 µM 0.5763423353058 0.287477546096553 no 988 0.282191906425959 1379 6459286
SGTC_1370 2001-0092 44.6 µM 0.575754684188605 0.28767928693573 no 989 0.282390503684599 1519 790957
SGTC_366 0181-0206 4.31 µM 0.575595195584 0.287734050971403 no 990 0.28244441460828 1445 274874
SGTC_876 0720-0963 56.8 µM 0.5744476725243 0.288128224226868 no 991 0.282832450423484 1491 765861
SGTC_842 0271-0008 11.1 µM 0.569412243696607 0.289860895043376 no 992 0.284538204879907 1444 1221709
SGTC_1040 k898-0338 155 µM 0.569356479657027 0.289880110556672 no 993 0.28455712245522 1465 20969351
SGTC_898 1000-0849 28.3 µM 0.568625412843132 0.290132081265703 no 994 0.28480518749266 1379 6751807
SGTC_1905 st060207 84.5 µM 0.567134640026641 0.290646211302258 no 995 0.285311354908096 1380 1948547
SGTC_2385 9074692 200 µM 0.566703663326604 0.290794923696529 no 996 0.285457765775207 1351 17046906
SGTC_2705 st078069 42.8 µM 0.566221933205428 0.290961191110102 no 997 0.285621460858979 1356 1530061
SGTC_1929 genistein trimethyl ether 50.5 µM 0.565283825597247 0.291285102986159 no 998 0.285940364166268 1433 136420
SGTC_1526 st051518 75 µM 0.561828563293398 0.292479592789329 no 999 0.287116414570845 1398 673993
SGTC_3335 9143315 29.6265 µM 0.559899157389036 0.293147580662191 no 1000 0.287774111767859 1388 4899691
SGTC_2517 totarol 10 µM 0.559570875925984 0.293261306780516 no 1001 0.287886087388948 1338 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.558712737455658 0.293558687130207 no 1002 0.288178892471243 1469 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_3301 9125354 19.7965 µM 0.558634872755744 0.293585677366554 no 1003 0.288205467605079 1382 41905162
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.557313439262366 0.294043900883511 no 1004 0.288656647546654 1450 688751
SGTC_3182 9108849 49.47 µM 0.55483653580857 0.29490368740926 no 1005 0.289503237148695 1396 17133045
SGTC_664 1222-0054 14.9 µM 0.554037494172972 0.295181298928891 no 1006 0.289776592964354 1387 6813991
SGTC_2440 5628896 157.78 µM 0.553549407248792 0.295350934437313 no 1007 0.289943629302126 1442 5522048
SGTC_1007 4101-0031 70 µM 0.553498334811712 0.295368687348854 no 1008 0.289961110258632 1452 1146276
SGTC_162 k030-0015 37.8 µM 0.552334981607026 0.295773204830846 no 1009 0.290359433890379 1488 1809920 YMR134W ERG29
SGTC_667 1498-1044 59 µM 0.551906830131851 0.295922144349951 no 1010 0.29050609429786 1455 6739982
SGTC_1472 k841-0093 193 µM 0.551830678018857 0.295948638719591 no 1011 0.290532183322983 1465 X1472
SGTC_2525 harmine 47.85 µM 0.550868447131594 0.296283505890786 no 1012 0.290861929335567 1455 5280953 A monoamine oxidase inhibitor
SGTC_2929 9013348 24.6 µM 0.550278455673536 0.296488915450475 no 1013 0.291064199439606 1424 2995952
SGTC_965 1291-5240 308 µM 0.550099663880038 0.296551175917941 no 1014 0.291125508609926 1469 2834598
SGTC_3256 9138902 49.47 µM 0.549816913618811 0.296649649952036 no 1015 0.291222478298783 1458 17228773
SGTC_1504 k297-0033 30 µM 0.548599781388139 0.297073714063627 no 1016 0.29164006795191 1320 4388117
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.547699900898537 0.29738742182921 no 1017 0.291948990095975 1459 5377381
SGTC_298 1391-0729 10 µM 0.547638058273868 0.29740898637184 no 1018 0.291970225794482 1396 3237558
SGTC_2488 5268135 45.7 µM 0.545857167363976 0.298030289766885 no 1019 0.292582061583149 1484 1270356 YLR208W SEC13
SGTC_2844 9010103 25.97 µM 0.545185410286057 0.298264800701593 no 1020 0.292813002405934 1412 2480525
SGTC_1950 st077106 7.18 µM 0.544218601628773 0.298602461781254 no 1021 0.293145526361768 1391 13831864
SGTC_1179 1021-1431 9.29 µM 0.543440174255342 0.298874456349978 no 1022 0.293413385688903 1428 2840958
SGTC_2324 6149169 200 µM 0.542695605618058 0.299134725427809 no 1023 0.293669700167937 1372 2888231
SGTC_1453 4237-0541 195 µM 0.541245700942166 0.299641844544033 no 1024 0.294169120656276 1421 739892
SGTC_504 lovastatin 124 µM 0.540951158805868 0.299744911275735 no 1025 0.294270623800858 1383 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1729 st035615 45.989 µM 0.539890777555864 0.300116094728747 no 1026 0.294636179191195 1399 17385451
SGTC_1567 st069303 68.4 µM 0.538261166545141 0.300686940303773 no 1027 0.29519837857255 1436 5581319
SGTC_154 3389-1638 511.116 µM 0.536218451823684 0.301403185578007 no 1028 0.295903791246599 1311 5238686
SGTC_2924 9010168 62.78 µM 0.535309604284435 0.301722105115711 no 1029 0.296217893082628 1440 2993929
SGTC_2339 9000433 200 µM 0.534675894076936 0.301944567207189 no 1030 0.296436996665246 1390 2988954
SGTC_1330 1469-0054 61.8 µM 0.534188504123696 0.302115714119508 no 1031 0.296605560935014 1519 7102664
SGTC_989 1501-0895 10.3 µM 0.532980282384005 0.302540168691922 no 1032 0.297023614759907 1455 2830112
SGTC_2964 9083345 53.42 µM 0.5319444144248 0.30290428716762 no 1033 0.297382247307758 1388 17741579
SGTC_1169 aniline yellow 25.8 µM 0.531163924853397 0.303178766973124 no 1034 0.297652594737705 1468 6051 A DNA damaging agent.
SGTC_11 0438-0307 1.3 µM 0.529322872322294 0.303826661973403 no 1035 0.298290745812225 1515 4011476
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.528602449273306 0.304080358069544 no 1036 0.298540630437006 1487 676296 Flavone; oxidizing agent.
SGTC_364 0083-0097 67.7 µM 0.528406476210694 0.304149386074791 no 1037 0.298608621766948 1466 5207356
SGTC_2575 plumbagin 510 nM 0.527048535772461 0.304627887971595 no 1038 0.299079941969364 1376 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_342 k048-0088 23.3 µM 0.526114643668226 0.304957160756296 no 1039 0.299404277402166 1401 6820570
SGTC_218 alverine citrate 93.75 µM 0.525914492346971 0.30502775091421 no 1040 0.299473809569822 1489 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_26 0302-0163 425.158 µM 0.525501429556314 0.305173454464678 no 1041 0.299617329892761 1455 3100915
SGTC_1510 1123-0200 71.5 µM 0.524689458081552 0.305459958857628 no 1042 0.299899543440058 1557 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1922 5578187 25 µM 0.51799333177871 0.30782722062522 no 1043 0.302231460907948 1546 1350412
SGTC_2221 6807166 181.081 µM 0.517890536643739 0.307863624243266 no 1044 0.302267322525321 1473 674925
SGTC_1154 4088-0362 150 µM 0.516694315299405 0.308287390127492 no 1045 0.302684782505586 1432 6618304
SGTC_1705 st027868 56.3335 µM 0.515879015193331 0.308576359761131 no 1046 0.30296945567832 1519 292948
SGTC_2426 5582046 32.21 µM 0.515458409254602 0.308725482963812 no 1047 0.303116362825274 1498 2251934
SGTC_2728 chlorpromazine 9.18 µM 0.513902004039624 0.309277570879867 no 1048 0.303660253155028 1479 2726 A thorazine and dopamine antagonist.
SGTC_968 1309-0633 340 µM 0.5131460371901 0.309545882925319 no 1049 0.303924585056155 1474 3761976
SGTC_3009 9080819 71.4286 µM 0.512476292898489 0.309783677211489 no 1050 0.3041588540011 1449 17027216
SGTC_1343 1487-0095 224 µM 0.512431433786356 0.309799607390893 no 1051 0.304174548083477 1479 4560101 YGL055W OLE1
SGTC_2923 7992654 58.14 µM 0.512119761962921 0.309910296839838 no 1052 0.304283597277965 1479 2985126
SGTC_2423 st077119 87.2 µM 0.511191898092199 0.310239927307137 no 1053 0.304608345644982 1402 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_3303 9125618 40.5795 µM 0.51072431748249 0.310406096570954 no 1054 0.304772055245087 1550 22695467
SGTC_1295 1013-0063 9.78 µM 0.51046188907411 0.310499375600363 no 1055 0.304863953966914 1549 6826038
SGTC_3345 9148410 3.559 µM 0.509790014873877 0.310738245876641 no 1056 0.305099290920074 1531 4903596
SGTC_2882 9058044 58.44 µM 0.509678426780955 0.310777926328788 no 1057 0.305138384620066 1387 18076804
SGTC_3031 9088762 49.47 µM 0.508460298378708 0.311211232867504 no 1058 0.305565287472855 1416 205253
SGTC_3158 9100007 49.47 µM 0.507937771555562 0.311397183752728 no 1059 0.305748492271884 1441 19297233
SGTC_1792 st045773 43.6 µM 0.507587945683381 0.311521702693225 no 1060 0.305871173018529 1457 2919270
SGTC_2502 avocadyne acetate 18.59 µM 0.506257335924258 0.311995524102329 no 1061 0.306338004673939 1415 3952079
SGTC_3118 9124250 49.47 µM 0.504694563474857 0.312552414568111 no 1062 0.306886690031051 1430 1504786
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.504327018660827 0.312683450595585 no 1063 0.307015796983241 1588 551469
SGTC_2298 7976326 193.81 µM 0.504012970194179 0.31279543301881 no 1064 0.307126131310877 1410 2235818
SGTC_930 2810-3379 265 µM 0.503250901729046 0.313067240837706 no 1065 0.307393940644653 1626 1015764
SGTC_2475 5812728 15.03 µM 0.501897804634316 0.313550101837944 no 1066 0.307869704822932 1446 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2972 9093619 59.92 µM 0.501495065900575 0.313693883396044 no 1067 0.308011374744178 1421 25236256
SGTC_2827 7993847 71.43 µM 0.501440404452139 0.313713400234869 no 1068 0.308030605006507 1505 2985692
SGTC_3020 9089140 49.47 µM 0.500396089562682 0.314086372343405 no 1069 0.308398103136021 1486 17217859
SGTC_1547 harmine 94.2 µM 0.499939921590339 0.314249350206623 no 1070 0.308558690568594 1483 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2942 9052777 62.25 µM 0.49895047246719 0.314602981078759 no 1071 0.30890713787957 1540 6469503
SGTC_250 brefeldin a 552.239 µM 0.497945726656098 0.31496225312907 no 1072 0.30926114819255 1421 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_672 1441-0018 53.7 µM 0.497841011915113 0.314999706593835 no 1073 0.309298053392583 1441 251141
SGTC_1408 3909-7976 48.8 µM 0.495821196090475 0.315722508739138 no 1074 0.310010284448948 1515 24152374
SGTC_1143 3454-2408 5.08 µM 0.49160694576015 0.317232870138833 no 1075 0.311498616156519 1473 X1143
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.490648100216885 0.317576941183252 no 1076 0.31183767996576 1548 6708739 YPR165W RHO1
SGTC_835 0312-0010 67.2 µM 0.490499996584599 0.317630100584495 no 1077 0.311890066116864 1470 1626196
SGTC_688 0527-0193 473 µM 0.488186754982126 0.31846088867077 no 1078 0.312708782672837 1533 4007154
SGTC_2957 9076800 11.52 µM 0.485431096877773 0.319451760664742 no 1079 0.313685289097535 1457 16459615
SGTC_360 0957-0399 1.01 µM 0.484339752062463 0.319844540632593 no 1080 0.314072384229428 1595 6752301 YPR165W RHO1
SGTC_1266 0828-0227 32.9 µM 0.480409048989044 0.3212608907122 no 1081 0.315468280575126 1550 3913820
SGTC_1017 4239-0030 168 µM 0.480283461620028 0.321306186630643 no 1082 0.315512923546889 1440 1149593
SGTC_2225 6654152 15.4 µM 0.47983574525229 0.32146768726558 no 1083 0.315672096723905 1558 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_679 0422-0091 41.4 µM 0.476084370716275 0.322822210163122 no 1084 0.31700713561272 1474 627384 YHR062C RPP1
SGTC_2658 polymyxin b sulfate 77.05 µM 0.474561874627 0.323372616137384 no 1085 0.317549643046163 1504 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_828 2074-0507 139 µM 0.472301967979475 0.3241903203924 no 1086 0.318355632932651 1601 X828
SGTC_3155 9099265 49.47 µM 0.472038669066037 0.324285645377582 no 1087 0.318449593857194 1554 25236499
SGTC_1936 st074407 74.3 µM 0.469679605579143 0.325140236213056 no 1088 0.319291970399695 1515 809813
SGTC_536 3852-0578 10.6 µM 0.468721208271936 0.325487687045247 no 1089 0.319634462757235 1617 2869208
SGTC_2841 9004761 38.96 µM 0.46796600128602 0.32576158153489 no 1090 0.319904451549331 1429 2991039
SGTC_163 TUB2.036 7.546 µM 0.46785542305395 0.325801693364542 no 1091 0.319943991615931 1534 15992207 YJR013W GPI14
SGTC_21 0849-0113 22.993 µM 0.465225964921032 0.326756112454124 no 1092 0.320884823251362 1511 1560156
SGTC_1787 fluconazole 80 µM 0.464301198557984 0.327092046587684 no 1093 0.321215982697746 1470 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2715 st079500 56.4 µM 0.463473825548994 0.327392720035454 no 1094 0.321512386068156 1484 28246688
SGTC_2761 levamisole 97.89 µM 0.462248160758303 0.327838341483972 no 1095 0.321951684916838 1639 26879 An alkaline phosphatase inhibitor.
SGTC_1781 st038725 66.3 µM 0.462138451782407 0.327878240926309 no 1096 0.321991018603801 1532 4270275 YIL048W NEO1
SGTC_1176 0848-0131 83.3 µM 0.461399066537893 0.328147195023224 no 1097 0.322256160554526 1641 6769040
SGTC_1242 0402-0103 60.1 µM 0.460604670108279 0.32843625895378 no 1098 0.322541130210139 1497 432868
SGTC_2683 piperine 63.03 µM 0.460599935480674 0.328437982091971 no 1099 0.322542828950993 1533 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1398 3558-0053 112 µM 0.460365091480149 0.328523456680273 no 1100 0.322627093467617 1507 4532369
SGTC_339 3091-4833 71.4 µM 0.459672171180583 0.328775706500522 no 1101 0.322875773700325 1584 3240077
SGTC_777 1315-0167 517 µM 0.459490711013556 0.328841777924323 no 1102 0.322940910526753 1497 4221767
SGTC_2817 7995342 71.43 µM 0.458863397099373 0.329070230264405 no 1103 0.323166132563658 1451 18879975
SGTC_3340 9146634 11.102 µM 0.457457509688026 0.329582451787614 no 1104 0.323671118153088 1538 4907387
SGTC_1416 3966-0321 25.3 µM 0.456496340622415 0.329932828639976 no 1105 0.324016550841846 1545 582530 YLR208W SEC13
SGTC_492 tmb-8 126 µM 0.456423984108216 0.3299592109471 no 1106 0.324042561048199 1537 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_356 1634-0012 32.5 µM 0.456265616705439 0.330016957109213 no 1107 0.324099492835956 1613 735457
SGTC_2464 5717415 7.67 µM 0.455308603426604 0.330366002977927 no 1108 0.324443618797816 1464 5285744
SGTC_1791 st048313 56.1 µM 0.455193411143807 0.330408026347945 no 1109 0.324485050132996 1634 1204976
SGTC_2345 9052315 157.45 µM 0.454512079508429 0.330656627095983 no 1110 0.324730149844147 1566 6469265
SGTC_1604 st002052 72.4 µM 0.453665938691135 0.330965466578563 no 1111 0.325034643065543 1569 6254834 YHR062C RPP1
SGTC_2177 5811945 192 µM 0.453217077188502 0.33112934673437 no 1112 0.325196218358186 1629 5343475
SGTC_1098 clofazimine 15.1 µM 0.451591172809125 0.331723238060933 no 1113 0.325781765159717 1594 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_67 0335-0847 266 µM 0.450708128569528 0.332045963562487 no 1114 0.326099961539313 1782 4552207 YOR254C SEC63
SGTC_1565 sinapyl alcohol 95.1 µM 0.44849963825399 0.332853644018296 no 1115 0.326896323593678 1478 5280507 A phenol propionate derived from cinnamic acid.
SGTC_868 0527-0199 213 µM 0.448314545568903 0.332921370696356 no 1116 0.326963102262845 1573 2849450
SGTC_148 3253-0744 288.01 µM 0.446961931041706 0.333416466943504 no 1117 0.327451273429125 1518 6893655
SGTC_59 0330-0160 1.33 µM 0.446076632128983 0.333740669349423 no 1118 0.327770945933755 1572 4293482
SGTC_2025 5147754 141 µM 0.444423038332253 0.334346558921145 no 1119 0.328368379997738 1623 315777 YLR208W SEC13
SGTC_1380 2291-0730 164 µM 0.443877517604288 0.334546536742336 no 1120 0.328565569957086 1531 2999191
SGTC_1443 4112-3303 14 µM 0.443697778857184 0.334612435932293 no 1121 0.328630550775106 1561 704433
SGTC_1876 myriocin 605 nM 0.443118513701321 0.334824851648353 no 1122 0.328840007340143 1660 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_477 mead ethanolamide 10 µM 0.442347685202631 0.335107595337138 no 1123 0.329118814694442 1521 16061185
SGTC_1201 1889-3372 45.9 µM 0.442011935368084 0.335230779259913 no 1124 0.329240284572318 1564 5392199
SGTC_1219 1469-0211 33.1 µM 0.441565984992568 0.335394422276233 no 1125 0.329401651430906 1626 6822282
SGTC_1296 1068-0102 11.9 µM 0.441435875380208 0.335442172331082 no 1126 0.329448737500632 1612 767053
SGTC_2086 5274770 176.623 µM 0.441135150874095 0.335552547996524 no 1127 0.329557578663196 1566 689278
SGTC_485 niflumic acid 177 µM 0.4407664616413 0.335687888290545 no 1128 0.329691037989178 1600 4488 A COX2 inhibitor.
SGTC_748 act1.228 77.9 µM 0.439584452077832 0.33612192994152 no 1129 0.330119051812397 1499 4421505 YNR035C ARC35
SGTC_150 3970-0969 77.2 µM 0.43902213488374 0.336328493262048 no 1130 0.33032274886571 1603 6615640
SGTC_2197 6588183 93.1375 µM 0.438408030853871 0.336554136571063 no 1131 0.330545262935738 1565 884136
SGTC_3055 9094636 49.47 µM 0.43685473544402 0.337125134262994 no 1132 0.331108350301827 1618 25236176
SGTC_1498 4478-3555 97.6 µM 0.43241221601677 0.338760291143189 no 1133 0.332720920535936 1619 3437919
SGTC_1501 4491-0275 38.4 µM 0.431304771967408 0.339168382873388 no 1134 0.333123390522561 1646 5104718
SGTC_52 0329-0193 875 nM 0.429914738486794 0.339680875565517 no 1135 0.333628831935834 1661 3739292
SGTC_2904 7225135 42.03 µM 0.426203496026191 0.341050627501981 no 1136 0.334979785125505 1628 4446116
SGTC_237 nikkomycin 200 µM 0.425559262735221 0.341288616428503 no 1137 0.335214514884698 1661 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_712 r015-0009 80.6 µM 0.423584563682459 0.342018491323328 no 1138 0.335934407435763 1661 6813872 YLR060W FRS1
SGTC_2214 7179297 48.276 µM 0.422755813783425 0.3423249843994 no 1139 0.336236714526858 1639 769744
SGTC_149 3970-0822 46.1 µM 0.421302577895919 0.34286267918368 no 1140 0.336767074021797 1615 3114250 YBL034C STU1
SGTC_456 gingerol 170 µM 0.420322768936279 0.34322538662241 no 1141 0.337124839396758 1644 442793 A herb.
SGTC_425 3825-7017 13.1 µM 0.41965754507926 0.343471722743883 no 1142 0.337367821841464 1663 3397440
SGTC_174 3553-0389 74.3 µM 0.417827773287268 0.344149640251404 no 1143 0.338036521607161 1640 738071
SGTC_943 3253-1379 105 µM 0.417292991174869 0.344347867980931 no 1144 0.338232057218485 1672 668464
SGTC_2210 7115885 190.385 µM 0.415894611356997 0.34486640754188 no 1145 0.338743561407144 1613 2927039
SGTC_410 α-linolenic acid 100 µM 0.414285314736067 0.345463518894915 no 1146 0.339332583693101 1678 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2746 daunorubicin 9.88 µM 0.413768204503427 0.345655468567287 no 1147 0.339521935831271 1672 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1409 3909-8004 61.9 µM 0.412263299223394 0.346214310278888 no 1148 0.340073222873468 1626 2119279
SGTC_1725 st036284 20.55 µM 0.411125504057034 0.346637049319154 no 1149 0.340490254843623 1759 707914
SGTC_414 piperonyl butoxide 100 µM 0.409955893203888 0.347071808375025 no 1150 0.340919151482597 1565 5794 A potent inhibitor of cytochrome P450.
SGTC_2838 9002687 71.43 µM 0.409930196674398 0.347081362360712 no 1151 0.340928576718478 1555 6457060
SGTC_1834 st055981 52.8 µM 0.408538605897042 0.34759890169917 no 1152 0.341439146753828 1710 471719 YDL150W RPC53
SGTC_1264 0783-0040 158 µM 0.408523106362778 0.34760466765285 no 1153 0.341444835117986 1553 2855798
SGTC_326 k292-0812 17.5 µM 0.40826690811597 0.347699980605577 no 1154 0.34153886567179 1712 3579357
SGTC_1558 st069300 45.6 µM 0.407982861272211 0.347805665273094 no 1155 0.341643128788301 1703 24208000
SGTC_1026 k007-1105 30.6 µM 0.407788269304744 0.34787807349355 no 1156 0.341714563295024 1612 7066794
SGTC_1821 st053465 65.6 µM 0.40644966773136 0.348376321146308 no 1157 0.342206116027801 1584 675086
SGTC_235 0330-0087 5 mM 0.405661508891483 0.348669808218995 no 1158 0.342495663863163 1604 46494818 YHR062C RPP1
SGTC_1499 4480-0877 67.3 µM 0.404076754616885 0.349260197955035 no 1159 0.343078139008089 1620 2861909
SGTC_1141 3253-0389 52.6 µM 0.404029952400128 0.349277639366737 no 1160 0.34309534680309 1695 5402031
SGTC_708 3448-5400 146 µM 0.402940088927629 0.349683880101152 no 1161 0.343496149411276 1609 3462195
SGTC_3217 9129673 49.47 µM 0.402257975108592 0.349938221985535 no 1162 0.343747089694219 1621 17248312
SGTC_1281 0884-0031 11.8 µM 0.401638740977166 0.350169176050308 no 1163 0.343974957042693 1594 1548255
SGTC_2564 betulinic acid 100 µM 0.401287102200254 0.350300350484372 no 1164 0.344104379209315 1835 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_404 fumagillin 50 µM 0.40009570980824 0.350744917145506 no 1165 0.34454301199991 1651 12015870 A methionine aminopeptidase binder.
SGTC_3107 9121808 49.47 µM 0.399543894468229 0.350950895701904 no 1166 0.344746243755375 1684 662681
SGTC_2007 4011539 71.82 µM 0.399119472919367 0.351109351221729 no 1167 0.344902587292018 1586 45595301
SGTC_100 0086-0128 49.5915 µM 0.397639341208738 0.351662152926262 no 1168 0.345448028307678 1533 93297
SGTC_2016 5121758 140 µM 0.39653973514415 0.352073038611968 no 1169 0.345853450366586 1588 2795203
SGTC_538 2922-0838 53.3 µM 0.395113054399654 0.352606398523291 no 1170 0.346379727527247 1759 777039
SGTC_244 nsc-207895 1.295 µM 0.392813994935713 0.353466503976832 no 1171 0.347228433700665 1578 42640
SGTC_2014 4013930 200 µM 0.392485188648128 0.353589575619926 no 1172 0.347349876504042 1650 64556
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.389808922599746 0.354591865815349 no 1173 0.348338922700634 1608 115019
SGTC_2129 girgensonine 121.053 µM 0.389120700749178 0.354849775397153 no 1174 0.348593430447089 1713 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3108 9121785 49.47 µM 0.38909850467769 0.354858094432898 no 1175 0.348601639796185 1762 17140271
SGTC_2192 5915882 198.485 µM 0.38899372995151 0.354897364689842 no 1176 0.348640392309216 1638 2876149
SGTC_2040 5100729 123 µM 0.387312572335246 0.355527684200645 no 1177 0.349262409558804 1679 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2353 9059630 146.67 µM 0.387280993614325 0.355539527856325 no 1178 0.349274097358923 1711 4779114
SGTC_2858 9025781 8.96 µM 0.38690390022286 0.3556809681815 no 1179 0.349413676821042 1696 4894980 YPL153C RAD53
SGTC_665 3914-0008 307 µM 0.386354572484533 0.355887045783907 no 1180 0.349617044508627 1594 1069549
SGTC_1896 st058441 89 µM 0.386268517521599 0.355919332697689 no 1181 0.349648906995498 1601 688759
SGTC_1693 xanthone 101.9 µM 0.385472552242108 0.356218019426432 no 1182 0.349943669209079 1690 7020 An insecticide.
SGTC_113 0099-0221 2.5 µM 0.385421001992304 0.356237366751158 no 1183 0.349962762440837 1751 89219
SGTC_1981 st071826 47 µM 0.384046121925023 0.356753509422965 no 1184 0.350472131705993 1622 11838600
SGTC_2731 amoxapine 43.43 µM 0.383661963171809 0.35689777310474 no 1185 0.350614503995736 1751 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_3294 9122953 26.2835 µM 0.383423437001028 0.356987357476798 no 1186 0.350702914253276 1606 16459826
SGTC_2306 7482397 179.52 µM 0.382862407283019 0.357198097071226 no 1187 0.350910893039171 1769 891448
SGTC_168 3970-0862 530.542 µM 0.382635169388669 0.357283466842963 no 1188 0.350995144896035 1669 3135186
SGTC_993 3909-8757 62.7 µM 0.381375152326285 0.357756965342276 no 1189 0.351462447947775 1661 4288324 YLR208W SEC13
SGTC_1086 cerivastatin 2.18 µM 0.381250384937743 0.35780386327781 no 1190 0.35150873271311 1698 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_986 1493-0483 84 µM 0.381149785805768 0.357841678340643 no 1191 0.351546053420968 1738 40079
SGTC_2172 5754775 163.918 µM 0.379822967283264 0.358340557852721 no 1192 0.352038416165248 1607 2263357
SGTC_2115 tiliquinol 12.7705 µM 0.379618266555157 0.358417546230674 no 1193 0.352114399697921 1669 71208 A bioactive hydroxyquinoline.
SGTC_3186 9110464 49.47 µM 0.378305188144418 0.358911534552853 no 1194 0.352601945871584 1712 17018021
SGTC_190 3970-0790 3.722 µM 0.377726014287243 0.359129498456619 no 1195 0.352817070227686 1740 2832352
SGTC_490 phenamil 164 µM 0.375564289481389 0.359943437599669 no 1196 0.353620421620099 1752 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2629 bisabolol 100 µM 0.374766755766163 0.360243888073 no 1197 0.353916970176191 1736 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_246 cycloheximide 667 µM 0.372974740857778 0.360919298653521 no 1198 0.354583621793367 1644 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1713 st033146 12.748 µM 0.370033416290728 0.362028824011132 no 1199 0.355678796093467 1789 674619
SGTC_1621 st003705 32.4 µM 0.368679933229898 0.36253977483518 no 1200 0.35618315383362 1778 24207032
SGTC_904 1141-0088 396 µM 0.367657016725226 0.362926096661093 no 1201 0.356564497340056 1594 1378119
SGTC_657 3534-0529 86.7 µM 0.367436879050403 0.363009253659527 no 1202 0.356646583483929 1764 1049549
SGTC_252 miconazole 1.30953 nM 0.367434638556961 0.363010100039052 no 1203 0.356647418965554 1719 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1061 3448-9325 110 µM 0.366410744168499 0.363396961243135 no 1204 0.357029301844619 1712 723482
SGTC_1508 1080-0625 72.9 µM 0.361290198355907 0.365333757176735 no 1205 0.358941260085031 1685 767111
SGTC_966 1300-0360 30.2 µM 0.36077359444286 0.365529349328151 no 1206 0.359134351918586 1674 70588
SGTC_1194 1488-0194 225 µM 0.360743893434767 0.365540595533172 no 1207 0.359145454404271 1684 1391452
SGTC_2303 7774051 200 µM 0.360440850379995 0.365655348557137 no 1208 0.359258741234644 1769 2953184
SGTC_2121 5257820 149.641 µM 0.35982797080285 0.36588746381978 no 1209 0.359487892314776 1814 791256
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.35904204701295 0.366185187786144 no 1210 0.359781817278661 1641 6708760
SGTC_3154 9100113 49.47 µM 0.358539649025939 0.366375548622775 no 1211 0.35996975086377 1645 25237525
SGTC_2236 dapsone 200 µM 0.358459575247164 0.366405891973874 no 1212 0.359999707441525 1733 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_691 1548-0686 185 µM 0.355349928089885 0.367584913483128 no 1213 0.361163727847228 1643 46495133
SGTC_3252 9135871 49.47 µM 0.355095462729514 0.367681449365138 no 1214 0.361259037834264 1746 17682838
SGTC_2134 5324836 1.464 µM 0.352318797348111 0.368735368041089 no 1215 0.362299596266847 1726 699272
SGTC_750 4073-0104 132 µM 0.351933597189789 0.368881653878467 no 1216 0.362444031056486 1653 22330957
SGTC_1496 4469-0713 57.4 µM 0.351657049931123 0.368986688779595 no 1217 0.362547737392511 1796 746691
SGTC_2767 sibutramine 71.45 µM 0.350749608127757 0.36933141125791 no 1218 0.362888102532712 1824 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_808 0711-0032 135 µM 0.350583045668764 0.369394697068027 no 1219 0.362950588899249 1834 4252555
SGTC_527 4476-4215 268 µM 0.34953501226844 0.369792981031352 no 1220 0.363343845174677 1727 4418754
SGTC_249 wiskostatin 11.211 µM 0.348561648373298 0.370163013513052 no 1221 0.363709212080054 1791 2775510 A n-wasp and actin depolymerizer.
SGTC_511 blebbistatin 171 µM 0.347645239332243 0.370511503998554 no 1222 0.364053313434365 1798 3476986 A myosin inhibitor.
SGTC_1463 k081-0032 34.1 µM 0.347263863419007 0.370656564324532 no 1223 0.36419654815196 1621 977755
SGTC_2600 tangeritin 87.95 µM 0.347178698944913 0.37068896003736 no 1224 0.364228536270353 1618 68077 A bioactive flavone.
SGTC_610 4215-0184 155 µM 0.345742679036086 0.371235345519347 no 1225 0.364768053381179 1724 5605015
SGTC_2903 5923464 63.88 µM 0.345289819806795 0.371407706019699 no 1226 0.364938249607699 1772 2876576
SGTC_2215 7188065 200 µM 0.344317146652676 0.371777997457558 no 1227 0.365303895303831 1790 940217
SGTC_396 dithiazanine 1.25 µM 0.342785352924137 0.372361383543599 no 1228 0.365879972889658 1687 10578 An antihelmenthic.
SGTC_141 0443-0274 32.331 µM 0.342528830032087 0.372459109376727 no 1229 0.365976475729043 1848 1627241
SGTC_582 0987-0078 156 µM 0.341385465301893 0.372894789288844 no 1230 0.366406707809551 1736 1625765
SGTC_3215 9129942 49.47 µM 0.340821132383638 0.373109888711922 no 1231 0.366619120297637 1855 17682944
SGTC_1096 rimcazole 32.2 µM 0.340043829948025 0.373406227705393 no 1232 0.366911760482714 1720 18528119 A dopamine reuptake inhibitor.
SGTC_3198 9112019 49.47 µM 0.339530924295485 0.373601809017163 no 1233 0.367104902477245 1734 45595555
SGTC_2249 haloperidol 116.36 µM 0.339366910099253 0.373664357824282 no 1234 0.367166671480215 1766 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_102 gallobenzophenone 83.616 µM 0.339297089461933 0.373690985782864 no 1235 0.367192967510637 1804 70837
SGTC_2373 9071805 200 µM 0.338850275133298 0.373861404591445 no 1236 0.367361262632257 1882 10149009
SGTC_2110 5483698 200 µM 0.337956170886958 0.374202497622847 no 1237 0.367698108493825 1728 2848765 YHR062C RPP1
SGTC_1202 1988-0068 29.6 µM 0.33792092424761 0.374215945930451 no 1238 0.367711389440441 1638 2850480
SGTC_2173 5763948 167 µM 0.337117931084097 0.374522368322428 no 1239 0.368014000382606 1739 2867177
SGTC_2060 5238662 140 µM 0.334525102019135 0.375512332811215 no 1240 0.36899167609675 1711 790130
SGTC_2401 5128683 200 µM 0.333435700558761 0.375928520781745 no 1241 0.369402709166985 1626 708373
SGTC_1786 berberine 21.6 µM 0.332400524195464 0.376324126720394 no 1242 0.36979342138857 1671 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2318 6029776 164 µM 0.332329708260985 0.376351194693105 no 1243 0.369820154748471 1785 818325
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.332241938482495 0.376384743777063 no 1244 0.369853289140105 1809 140250 A respiratory chain inhibitor.
SGTC_1835 st008666 49.2 µM 0.331158435378241 0.376798978409523 no 1245 0.370262407131621 1683 690455
SGTC_292 k038-0015 474 µM 0.330901488728166 0.376897232645165 no 1246 0.370359448709302 1773 46368540
SGTC_3093 9117344 49.47 µM 0.330212216443058 0.377160843928257 no 1247 0.370619808351527 1750 24824913
SGTC_2865 9030313 51.95 µM 0.328977139066457 0.377633340802 no 1248 0.371086483771833 1665 42562754
SGTC_1077 5-fluorocytosine 377 nM 0.328480272291524 0.377823476145873 no 1249 0.371274278990798 1748 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1514 1189-1591 158 µM 0.326254783498085 0.378675463611264 no 1250 0.372115797817612 1809 767698 YMR146C TIF34
SGTC_3005 9076496 71.4286 µM 0.325166834130838 0.379092179994691 no 1251 0.372527404214805 1807 21368410
SGTC_3092 9117248 49.47 µM 0.324698189153935 0.379271728049497 no 1252 0.372704752656213 1840 17141857
SGTC_894 0960-0238 55.9 µM 0.322817984767237 0.379992336623882 no 1253 0.373416545878961 1815 6741907 YDL195W SEC31
SGTC_647 0140-0236 81 µM 0.322599760770279 0.380076000365662 no 1254 0.373499187463695 1775 990837
SGTC_3268 9137683 49.47 µM 0.320712110055604 0.380799930614247 no 1255 0.374214284601163 1753 1953228
SGTC_1067 clotrimazole 1.36 µM 0.318364578107255 0.381700811523258 no 1256 0.375104202050136 1741 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_699 0375-0592 111 µM 0.317819696049578 0.381910005471325 no 1257 0.37531085473127 1884 762578
SGTC_2855 9016525 58.44 µM 0.317545152126271 0.382015422869306 no 1258 0.375414992181449 1731 43811474
SGTC_2168 5727979 200 µM 0.317000365112845 0.382224632158202 no 1259 0.375621662605732 1721 695210
SGTC_3347 9188721 44.724 µM 0.316811836656918 0.382297038930611 no 1260 0.37569319108504 1803 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1471 k673-0312 37 µM 0.316380099581416 0.382462868595568 no 1261 0.375857010015895 1855 24099884
SGTC_23 0213-0011 39.996 µM 0.31564899522633 0.382743733999624 no 1262 0.376134472312493 1868 627608
SGTC_3146 9095609 49.47 µM 0.315531022897451 0.382789060735057 no 1263 0.376179250137318 1810 17173999
SGTC_670 4204-0025 119 µM 0.315229878788247 0.382904772089537 no 1264 0.376293560584416 1827 719039
SGTC_3129 9127257 49.47 µM 0.314553608092302 0.383164659834925 no 1265 0.376550303813868 1627 837894
SGTC_478 N-arachidonylglycine 10 µM 0.310997172684133 0.384532244761301 no 1266 0.377901385502318 1855 5283389
SGTC_341 1486-1430 230 µM 0.310647934867455 0.384666617837317 no 1267 0.378034141022894 1709 2054753 YPL210C SRP72
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.310030952742853 0.384904042323901 no 1268 0.378268709185862 1728 4174840
SGTC_2250 alverine citrate 130 µM 0.306182529654542 0.386385947439261 no 1269 0.379732836687803 1739 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.30609413633084 0.386420004460105 no 1270 0.379766486166702 1794 165521
SGTC_1356 1502-0781 85.8 µM 0.303869446465926 0.387277441614361 no 1271 0.380613677980467 1776 567702
SGTC_1158 4092-0494 91.8 µM 0.303050119272761 0.387593364527707 no 1272 0.380925833345532 1864 1148199
SGTC_1373 2887-0003 58.5 µM 0.303048708626185 0.387593908520659 no 1273 0.380926370854496 1770 776948
SGTC_129 0088-0017 176.636 µM 0.301450520498919 0.38821036532994 no 1274 0.381535487509707 1890 182446
SGTC_2866 9034245 58.44 µM 0.300690106812808 0.388503772869061 no 1275 0.381825406745528 1898 6462273
SGTC_3121 9125696 49.47 µM 0.300463450043465 0.388591241272448 no 1276 0.381911835904664 1889 1235365
SGTC_1557 sumaresinolic acid 42.3 µM 0.300264869541856 0.388667879494369 no 1277 0.381987563809661 1740 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_554 4483-2211 187 µM 0.299730803891836 0.38887401307374 no 1278 0.382191250071221 1780 747107
SGTC_430 0958-0115 16.4 µM 0.298534069604594 0.389336030718624 no 1279 0.382647788557496 1763 6833180
SGTC_627 1391-0720 175 µM 0.297080682655238 0.389897343436536 no 1280 0.383202455987378 1803 997839
SGTC_776 4476-4378 112 µM 0.293458109983767 0.391297414979923 no 1281 0.384586007033074 1778 2892008
SGTC_3022 9087993 49.47 µM 0.293197734831856 0.391398100695768 no 1282 0.384685507696545 1839 17173644
SGTC_385 1494-0393 12.4 µM 0.293107268987386 0.391433085070662 no 1283 0.38472008040653 1830 3090647
SGTC_2620 irigenin 100 µM 0.292492838834394 0.391670716808221 no 1284 0.384954917199388 1867 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_899 1083-0020 478 µM 0.292487874043076 0.391672637113105 no 1285 0.384956814927478 1904 767123
SGTC_3088 9117578 49.47 µM 0.291377814901652 0.392102057095278 no 1286 0.385381189970817 1859 678341
SGTC_997 3996-0078 137 µM 0.290532122267874 0.392429296666358 no 1287 0.385704589994116 1802 735687
SGTC_523 1934-0222 13.7 µM 0.289872308012982 0.392684663705372 no 1288 0.385956963750956 1755 1361595
SGTC_2528 xanthyletin 44.79 µM 0.289330445478832 0.392894414604523 no 1289 0.38616425800876 1770 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1695 st026914 34.495 µM 0.288714597052468 0.393132842646242 no 1290 0.38639989567568 1788 3289191
SGTC_964 1287-0107 19.4 µM 0.285594091747693 0.394341572545232 no 1291 0.387594514586128 1910 51516812 YPR165W RHO1
SGTC_541 4513-1321 94 µM 0.285337661226719 0.394440946515319 no 1292 0.387692731047804 1753 747515
SGTC_2733 amorolfine 100 µM 0.285325984632182 0.394445471684562 no 1293 0.387697203517289 1938 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1623 st003709 20.3 µM 0.284933884525629 0.394597435158658 no 1294 0.387847397714098 1753 16192618
SGTC_391 gliotoxin 8.33 µM 0.284619516396226 0.394719284185404 no 1295 0.387967828748958 1846 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2262 9014885 67.46 µM 0.283657404202527 0.395092262636708 no 1296 0.388336470448501 1924 6457424
SGTC_1051 3253-3903 78 µM 0.283622942510333 0.395105624058156 no 1297 0.38834967661565 1805 5509239
SGTC_1996 st072960 66.8 µM 0.28361912180863 0.395107105420915 no 1298 0.388351140766016 1936 1719405
SGTC_2778 tioconazole 65.09 nM 0.28239367358976 0.395582314411191 no 1299 0.388820832712911 1766 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_481 bay k-8644 50 µM 0.282026739445749 0.395724635775974 no 1300 0.38896150353265 1774 2303 A calcium channel antagonist.
SGTC_180 1486-1293 102.781 µM 0.281100517300532 0.39608394787895 no 1301 0.389316652205651 1973 4140536
SGTC_1574 spiramycin 23.7 µM 0.279834052958391 0.396575394011181 no 1302 0.389802412252207 1791 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2785 7756463 72.73 µM 0.279716775470205 0.39662091137048 no 1303 0.389847403462583 1773 2201551
SGTC_892 0929-0076 29 µM 0.279628503902072 0.396655171975193 no 1304 0.389881268093633 1795 5751038
SGTC_1915 st067105 30.6 µM 0.279028611503547 0.396888027710198 no 1305 0.390111433805238 1795 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2374 9071832 200 µM 0.278934382825194 0.396924607093328 no 1306 0.390147590810208 1881 17381698
SGTC_1873 rapamycin 2 nM 0.278448063956889 0.397113409510449 no 1307 0.390334214003543 1782 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_358 0075-0058 9.45 µM 0.278257120895599 0.397187545475981 no 1308 0.390407494658475 2036 1069125
SGTC_164 4100-3994 89.624 µM 0.277627196419957 0.397432147643603 no 1309 0.390649276409029 1958 4615967
SGTC_3105 9121040 49.47 µM 0.277590072917309 0.397446564106273 no 1310 0.390663526716072 1934 41448907
SGTC_197 4544-0043 41.561 µM 0.27723546385968 0.39758427929667 no 1311 0.390799655104975 1828 896523
SGTC_2024 5144227 134 µM 0.277195606561962 0.39759975898713 no 1312 0.390814956480966 1878 3475211
SGTC_2891 9063876 19.48 µM 0.276875103871078 0.39772424098365 no 1313 0.390938004889227 1986 6472478
SGTC_2681 menadione 3.18 µM 0.27655416491381 0.397848902860104 no 1314 0.391061231732264 1840 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_768 0384-0033 77.3 µM 0.275771746839673 0.398152860120345 no 1315 0.391361692645617 1756 3965305 YMR134W ERG29
SGTC_1316 1272-0050 65.9 µM 0.275011084305903 0.398448424956126 no 1316 0.391653861246848 1831 7340392
SGTC_1631 benzylvanillin 81.9 µM 0.272042364174987 0.399602513832392 no 1317 0.392794722680034 1840 75506
SGTC_3142 9086498 49.47 µM 0.271715946740864 0.399729462234331 no 1318 0.392920219367073 1966 25236367
SGTC_2031 5180455 200 µM 0.271628855683587 0.399763334982243 no 1319 0.392953704874342 1813 29949
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.271209169293886 0.399926576220217 no 1320 0.393115080554028 1900 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2943 9068529 45.32 µM 0.270990282202963 0.400011721494983 no 1321 0.393199253197124 1868 3270634
SGTC_2674 ligustilide 100 µM 0.270263985745716 0.400294278866797 no 1322 0.393478584962447 1837 5319022 A signalling regulator.
SGTC_1403 3909-7815 62.9 µM 0.269765884034609 0.400488089851629 no 1323 0.393670185317766 1828 6615483
SGTC_2113 5491891 107.031 µM 0.269358458399664 0.400646637067669 no 1324 0.393826925258483 1751 789979
SGTC_709 3807-1509 243 µM 0.268250604191038 0.401077834518508 no 1325 0.394253212655343 1858 1886677 YPL242C IQG1
SGTC_810 3825-7150 143 µM 0.267777453759508 0.401262030222451 no 1326 0.3944353132174 1997 22330411 YGL099W LSG1
SGTC_133 0724-0033 378.92 µM 0.267100560425411 0.401525580427707 no 1327 0.394695868053313 1897 280309
SGTC_3281 9140613 49.47 µM 0.266558926270312 0.401736499387796 no 1328 0.394904391853106 1740 16013766
SGTC_1068 loratadine 26.9 µM 0.266113820410359 0.401909850481369 no 1329 0.395075775752974 1807 3957 A H1 histamine antagonist.
SGTC_3071 9117417 49.47 µM 0.265745120524426 0.402053459092078 no 1330 0.395217755612861 1971 45595590 YGL055W OLE1
SGTC_860 0443-0016 25.1 µM 0.264375887812935 0.402586890849115 no 1331 0.395745144739111 1957 5337942
SGTC_3222 9128301 49.47 µM 0.264225773372423 0.40264538415189 no 1332 0.395802976142615 1812 4911358
SGTC_528 3492-0019 172 µM 0.263434431671094 0.402953772827445 no 1333 0.396107877450036 1854 2869262
SGTC_288 1315-0019 35.1 µM 0.262962368334184 0.403137766353878 no 1334 0.39628979215519 1861 6811474
SGTC_600 1495-0418 41.6 µM 0.262822338426962 0.403192349165916 no 1335 0.396343758537027 1850 5377768
SGTC_161 4065-0411 162.148 µM 0.262327293066292 0.403385329971784 no 1336 0.396534560889114 1854 1906281 YLR208W SEC13
SGTC_300 r073-0011 5.04 µM 0.260315245211026 0.404169917186321 no 1337 0.397310306947782 1971 2735780
SGTC_2826 7992541 19.48 µM 0.260085754251974 0.404259430507563 no 1338 0.397398813178164 1905 2985066
SGTC_809 3998-0021 90 µM 0.258980748909752 0.404690509730639 no 1339 0.397825047017176 1972 715485
SGTC_3351 9150312 21.596 µM 0.25686033220435 0.405518039846314 no 1340 0.398643296839958 1931 4904905
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.255758524083981 0.405948206991898 no 1341 0.399068650946197 1845 390807
SGTC_1575 cyproterone acetate 48 µM 0.255389056768409 0.406092479614196 no 1342 0.399211311029525 1790 9880 An androgen receptor antagonist and liver toxin.
SGTC_576 1073-0113 22.7 µM 0.253566825483583 0.406804225604431 no 1343 0.399915114274822 1985 5439563
SGTC_3312 9133330 71.43 µM 0.253473676453678 0.406840617011161 no 1344 0.399951100127868 1928 17617324
SGTC_3079 9117512 49.47 µM 0.252521070554272 0.407212826633295 no 1345 0.400319164879129 1902 7185044
SGTC_2626 ethyl orsellinate 100 µM 0.25235306660421 0.407278479152424 no 1346 0.400384086890229 1835 75653 A natural product.
SGTC_936 3005-4620 401 µM 0.251874390355405 0.407465550351445 no 1347 0.400569077537951 1978 777207
SGTC_2058 5236698 133 µM 0.251654573376025 0.407551463976971 no 1348 0.400654036137692 1841 766665
SGTC_1640 st009078 66.4 µM 0.250864917904172 0.40786013085639 no 1349 0.400959274336446 1938 690618
SGTC_1062 mesoridazine 14.2 µM 0.250499097987682 0.408003144885123 no 1350 0.40110070108541 1870 4078 A neuroleptic.
SGTC_236 1509-0011 5.31 µM 0.25010968011036 0.408155397794692 no 1351 0.401251265096871 1948 3107280
SGTC_128 0906-2981 13.371 µM 0.248492107504653 0.408787977497369 no 1352 0.401876837959224 1981 6740226
SGTC_259 usnic acid 108.925 µM 0.247990887741113 0.408984036452573 no 1353 0.402070728580283 1946 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_383 2324-0395 7.37 µM 0.247755312559663 0.409076192772182 no 1354 0.402161866233115 1924 3146421
SGTC_730 1436-0052 41.2 µM 0.247528986701293 0.409164735517693 no 1355 0.402249430583817 1902 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_800 3448-7362 155 µM 0.24751685661853 0.409169481155085 no 1356 0.402254123791147 1906 15991913
SGTC_1461 k072-0203 53.8 µM 0.246629511141481 0.409516672299927 no 1357 0.402597481660012 1940 5418714
SGTC_1111 tnp00062 510.699 nM 0.245223870970395 0.410066801471495 no 1358 0.403141547101537 1987 676306
SGTC_1191 1487-1166 10.6 µM 0.244625865441512 0.41030089825063 no 1359 0.403373067354798 1941 3955771
SGTC_1904 st060225 78 µM 0.24452304500661 0.410341151824858 no 1360 0.40341287811572 1831 66595
SGTC_1306 1185-0270 9.02 µM 0.244517054412776 0.410343497134995 no 1361 0.403415197628104 1966 1548076
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.244402234483215 0.410388449616154 no 1362 0.403459655688362 1849 5355888
SGTC_2199 6590217 200 µM 0.244150698472189 0.410486931127242 no 1363 0.403557054317166 1944 703109
SGTC_2692 st077426 47.7 µM 0.243216523320775 0.410852729232786 no 1364 0.40391883367976 1976 25238571
SGTC_2707 st078556 66.6 µM 0.24105678420832 0.41169872190255 no 1365 0.404755553202793 2024 17250899
SGTC_2321 7390090 138.78 µM 0.240423985872579 0.411946673669593 no 1366 0.405000792699597 1807 649046
SGTC_1360 1598-0022 39.8 µM 0.240069137137236 0.412085730785056 no 1367 0.405138329821444 1948 761525
SGTC_1743 st037606 46.3785 µM 0.239117963575374 0.412458528389371 no 1368 0.405507056421091 1873 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2679 rapamycin 1 nM 0.235855806223566 0.413737677979485 no 1369 0.406772281176956 1901 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2008 4012253 172 µM 0.234427263324276 0.414298124085236 no 1370 0.407326647592492 1860 603940
SGTC_3056 9094900 49.47 µM 0.233245687309862 0.414761812062276 no 1371 0.407785315343976 1809 25236784
SGTC_705 1124-0212 310 µM 0.232862726625236 0.414912123525538 no 1372 0.407934001338384 2012 9554485
SGTC_3004 9076122 71.4286 µM 0.232503567308172 0.415053104310281 no 1373 0.408073458407892 1973 44782551
SGTC_2863 9028737 58.44 µM 0.230497247102627 0.41584084580344 no 1374 0.408852701199731 2043 6460917
SGTC_442 cape 100 µM 0.230326538456025 0.415907886798682 no 1375 0.408919020099953 2020 5281787
SGTC_1019 4262-0212 3.4 µM 0.229233724382146 0.416337116531829 no 1376 0.409343631047752 2029 4677213
SGTC_2188 6126565 140.678 µM 0.228583061813352 0.416592727764341 no 1377 0.409596495378853 1982 874518
SGTC_948 3448-0295 75.3 µM 0.228549337501858 0.416605977241763 no 1378 0.409609602546111 1886 678569
SGTC_857 0438-0306 1.35 µM 0.228413087293854 0.416659507662407 no 1379 0.409662558080839 1926 4686136
SGTC_922 1866-0035 480 µM 0.227256843188366 0.417113838681273 no 1380 0.410112014645611 1888 3156169
SGTC_3317 9138495 8.753 µM 0.227242692507147 0.417119399693577 no 1381 0.410117516047804 1939 17020139
SGTC_473 2-arachidonoylglycerol 10 µM 0.227179108685929 0.417144387416942 no 1382 0.410142235936366 1842 5282280 An endocannabinoid.
SGTC_906 1165-0455 526 µM 0.226744276001946 0.417315280714331 no 1383 0.410311298184119 1863 3252859
SGTC_1324 1418-0026 34.4 µM 0.226323721646476 0.417480577355734 no 1384 0.410474824898623 1918 1372513
SGTC_1820 st053765 18.6 µM 0.226315313049365 0.417483882458683 no 1385 0.410478094623523 1855 3690829
SGTC_2621 lithochol-11-enic acid 100 µM 0.225125720163347 0.417951525280524 no 1386 0.410940736352022 2040 6708711
SGTC_569 4130-2812 160 µM 0.224243813374951 0.418298288048583 no 1387 0.411283796634417 2047 743552
SGTC_1312 1218-2183 165 µM 0.223485133729093 0.41859664915173 no 1388 0.411578976063933 2010 6744073
SGTC_905 2-aminofluorene 215 µM 0.222297762001651 0.419063693203694 no 1389 0.412041047093669 1916 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2734 clemastine 41.6 µM 0.2222681722499 0.419075333577378 no 1390 0.412052563638527 1984 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1583 clindamycin 39.6 µM 0.221870253803899 0.41923187841612 no 1391 0.41220744372279 1829 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2368 9071271 200 µM 0.221429612971255 0.419405245559985 no 1392 0.412378968412193 1852 27209959
SGTC_3319 9138450 16.7555 µM 0.219579127497022 0.420133476955803 no 1393 0.413099474269247 1904 2029690
SGTC_1553 gossypol 38.6 µM 0.219352088963628 0.420222843525294 no 1394 0.413187894309342 1992 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1344 1488-0097 29.1 µM 0.219196022036358 0.420284276742489 no 1395 0.41324867704808 1936 747966
SGTC_182 3448-4371 550.524 µM 0.219101247404375 0.420321584188592 no 1396 0.413285589545705 2097 3491403
SGTC_384 k007-0144 5.16 µM 0.218617231573711 0.420512125174676 no 1397 0.413474114312731 1936 6824886
SGTC_724 3910-0327 137 µM 0.21805752420013 0.420732486633071 no 1398 0.413692145900224 1880 2885483
SGTC_2795 7780010 54.55 µM 0.217334637899857 0.421017129745636 no 1399 0.413973782504598 1927 953673
SGTC_683 panaxydol 45 µM 0.217033686946973 0.42113564412638 no 1400 0.414091046092305 1997 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_204 PMA1.184 62.41 µM 0.215917797343078 0.421575143356981 no 1401 0.414525912015344 1943 2252213 YGL008C PMA1
SGTC_2730 imipramine 71.33 µM 0.215262631133459 0.421833229718965 no 1402 0.41478128134224 2036 3696 A tricyclic antidepressant.
SGTC_371 0195-0006 7.36 µM 0.214976163605871 0.421946087002077 no 1403 0.41489295138473 1874 3928593
SGTC_1153 4055-0057 267 µM 0.214174241142864 0.4222620479361 no 1404 0.415205591302597 1869 882706
SGTC_1114 scopoletin 1.73284 µM 0.212764259731939 0.422817707943702 no 1405 0.415755421020699 2042 5280460 A coumarin with genotoxic properties.
SGTC_2797 7859098 81.82 µM 0.211744421756498 0.423219711997686 no 1406 0.416153215114392 1913 972681
SGTC_3147 9097027 49.47 µM 0.211380431065861 0.423363210771625 no 1407 0.416295212752373 1960 25236841
SGTC_2073 5212005 126 µM 0.211074789962785 0.423483713803985 no 1408 0.416414455875356 2079 691789
SGTC_2777 climbazole 1.536 µM 0.209644308741247 0.424047794831208 no 1409 0.416972647323465 2008 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2481 5478948 45.16 µM 0.208258692270393 0.424594332773171 no 1410 0.417513491630689 1900 77792
SGTC_900 1112-0045 141 µM 0.208129735216678 0.424645205555359 no 1411 0.41756383507875 2051 56211 YIL048W NEO1
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.207479967066696 0.42490155426215 no 1412 0.417817518122567 2037 77254
SGTC_2581 avocatin a 64 µM 0.206396536159163 0.425329063632945 no 1413 0.418240588165337 1931 6710728 A skin care supplement.
SGTC_1297 1068-0111 14.1 µM 0.20423073982292 0.426183924688403 no 1414 0.419086595331463 1890 767057
SGTC_46 0329-0187a 2.197 µM 0.203774067140837 0.426364222303304 no 1415 0.419265029525192 1978 46494817
SGTC_1671 st016596 74.5 µM 0.202284936673741 0.426952248301725 no 1416 0.419846987675434 1962 2829167
SGTC_630 4356-0227 183 µM 0.201378859843955 0.427310118337534 no 1417 0.420201172004057 1998 779312
SGTC_2624 nerol 100 µM 0.201311299841783 0.427336804678519 no 1418 0.420227583719279 1998 637566 A natural product oil.
SGTC_3275 9138069 49.47 µM 0.198981366198411 0.428257335943781 no 1419 0.421138660375874 1972 17617007
SGTC_1774 st048371 48.465 µM 0.196091439746316 0.429399656324099 no 1420 0.42226929814372 1888 4242727
SGTC_2995 9067767 71.4286 µM 0.194799777986148 0.429910411850251 no 1421 0.422774848050657 1954 11673567
SGTC_887 0885-0007 9.62 µM 0.191939068798909 0.431042024624148 no 1422 0.423894966942682 2031 5719458
SGTC_3221 9128209 49.47 µM 0.191859330291215 0.431073574998427 no 1423 0.423926197638213 1960 16460723
SGTC_399 oxolinic acid 75 µM 0.191437769781678 0.431240382413421 no 1424 0.424091315610347 1947 4628 A DNA gyrase inhibitor.
SGTC_1633 st005664 67.9 µM 0.190909447153634 0.431449451879526 no 1425 0.424298269273015 1958 2063822
SGTC_2041 5107442 45.335 µM 0.188714424164682 0.432318278188562 no 1426 0.425158322936408 2059 793005
SGTC_2635 hydroquinidine 100 µM 0.187802209254506 0.43267944444077 no 1427 0.425515851925024 1959 442912 An experimental heart treatment.
SGTC_2649 anisomycin 9.56 µM 0.187682606976604 0.43272680183067 no 1428 0.425562732797112 1988 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3211 9128781 49.47 µM 0.187548680022534 0.43277983232686 no 1429 0.425615229805436 1838 17194361
SGTC_1238 0333-0287 48.8 µM 0.187163000903017 0.432932554835874 no 1430 0.425766416593968 1977 7226
SGTC_824 1304-0008 100 µM 0.186876356542597 0.433046067720318 no 1431 0.425878788680757 1963 768245
SGTC_1134 3477-0009 42.5 µM 0.186588388453761 0.433160110372 no 1432 0.425991685765059 2115 3973534
SGTC_2886 9058944 51.95 µM 0.186520974700916 0.433186808728795 no 1433 0.426018116015053 2034 4949929
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.185532125654 0.433578464757839 no 1434 0.426405842508288 2001 229346 A bile salt which induces apoptosis.
SGTC_3299 9121982 43.1275 µM 0.184595155023442 0.433949633362214 no 1435 0.426773293183894 1951 17594604 YPL160W CDC60
SGTC_2877 9040724 71.43 µM 0.183728440693866 0.434293022722495 no 1436 0.427113248124826 2122 6463895
SGTC_757 1066-0008 322 µM 0.183564856167418 0.434357839942884 no 1437 0.427177417640106 2045 6842497
SGTC_832 4083-0019 164 µM 0.183464197428305 0.434397724908177 no 1438 0.427216904132579 2055 1990758
SGTC_1171 0368-0077 21.4 µM 0.183264263537807 0.434476948586709 no 1439 0.427295336524875 1957 3239779
SGTC_1737 st035557 69.7 µM 0.182202904817987 0.434897555298374 no 1440 0.427711746718775 1997 5716916
SGTC_2227 7312221 64.1025 µM 0.181531240474978 0.43516376780766 no 1441 0.427975307064747 2061 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_818 4072-2707 53.5 µM 0.181494407459961 0.435178367333662 no 1442 0.427989761229689 2013 882871
SGTC_2180 6301957 200 µM 0.181026661564995 0.435363775756561 no 1443 0.428173324417557 2080 845462
SGTC_703 3875-0075 71.8 µM 0.181000452295224 0.435374165192919 no 1444 0.428183610499041 2005 2850814
SGTC_1233 0325-0408 14.2 µM 0.180393153494198 0.435614912811407 no 1445 0.428421964439386 2051 12874
SGTC_2018 5133068 143 µM 0.180356836585227 0.435629310450755 no 1446 0.42843621900632 1987 785362
SGTC_1399 3562-5772 25 µM 0.179522508596252 0.435960098663006 no 1447 0.428763722555775 2008 23847490
SGTC_1947 st076332 61.6 µM 0.179484463130013 0.435975183718901 no 1448 0.428778657931975 2084 24208416
SGTC_1045 1348-1485 165 µM 0.178398536438024 0.436405793653422 no 1449 0.429204999310973 2092 6810614
SGTC_2642 cholecalciferol 100 µM 0.177510107710717 0.436758144455427 no 1450 0.429553863251889 2071 9821465 A vitamin D precursor, similar to steriods.
SGTC_2741 miltefosine 3.04 µM 0.177169246447736 0.436893343354829 no 1451 0.429687725640637 2019 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1388 3346-4487 254 µM 0.176064119665096 0.437331730440368 no 1452 0.430121784451543 2046 3345614
SGTC_3 0833-0587 95.581 µM 0.175819977890916 0.437428588187214 no 1453 0.430217687019637 2014 5382644
SGTC_3046 9092212 49.47 µM 0.175368828642578 0.437607581347165 no 1454 0.430394916071391 2062 25236637
SGTC_1145 3546-0597 10.2 µM 0.174799691491868 0.437833404337978 no 1455 0.430618515379709 2005 875334
SGTC_2496 diffractaic acid 79.83 µM 0.173961837938259 0.438165885803751 no 1456 0.430947726892779 2095 94870 An apoptosis inducer which activates caspases.
SGTC_418 lividomycin a 100 µM 0.173822244676573 0.438221284186556 no 1457 0.431002580895807 2108 72394 An antibiotic.
SGTC_1646 st011709 75.6 µM 0.173515543782175 0.438343004437912 no 1458 0.431123105511044 2104 5757843
SGTC_3334 9142812 21.919 µM 0.173008351327701 0.438544306481068 no 1459 0.431322431601945 2044 45283678
SGTC_645 0845-0943 5.41 µM 0.17195936882188 0.438960692563759 no 1460 0.431734736043618 2007 1885106
SGTC_440 fluspirilene 35.1 µM 0.17182544839477 0.439013856189425 no 1461 0.431787379069189 2053 3396 An atypical antipsychotic.
SGTC_283 0987-0079 11.7 µM 0.171042647928341 0.439324633682007 no 1462 0.432095115741405 2088 411556
SGTC_2234 tolnaftate 200 µM 0.170574108499199 0.439510665156437 no 1463 0.4322793289751 2108 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_865 0488-0499 301 µM 0.170040599399691 0.439722508810026 no 1464 0.432489103924117 2139 9634651
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.168614862099992 0.440288719393861 no 1465 0.433049794842752 1973 688667
SGTC_281 1672-3440 14.9 µM 0.167932809801931 0.440559629682515 no 1466 0.433318069083667 2089 6833000
SGTC_462 ag-879 158 µM 0.167856520875352 0.440589933277737 no 1467 0.433348078012194 2122 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2451 5856223 45.7 µM 0.167728510257176 0.440640782618032 no 1468 0.433398432991945 1987 2179896
SGTC_2654 protoveratrine a 100 µM 0.166946931393906 0.440951268452865 no 1469 0.433705902691117 2061 5702278 A heart drug and vasodilator.
SGTC_1243 0416-0003 5.65 µM 0.166919797288268 0.440962048255487 no 1470 0.433716577851039 1984 2141977
SGTC_2697 mebhydrolin 72.4 µM 0.165967130508692 0.441340550162013 no 1471 0.434091408718839 2106 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2326 6164455 177.58 µM 0.165855118750126 0.44138505683013 no 1472 0.434135484130517 1990 2888790
SGTC_2981 9013952 38.96 µM 0.164908376742046 0.441761264101473 no 1473 0.434508049493881 1884 2996344
SGTC_1610 st001799 48.1 µM 0.16437199622307 0.441974429193307 no 1474 0.434719153744936 1931 621897
SGTC_97 0535-0701 19.132 µM 0.163471774556234 0.442332227565493 no 1475 0.435073497418395 2066 2832013 YGL099W LSG1
SGTC_3110 9122132 49.47 µM 0.163392539404931 0.442363722297222 no 1476 0.435104688320763 2084 918317
SGTC_41 0478-0632 82.643 µM 0.161952422693813 0.442936209419236 no 1477 0.435671660169667 2167 3750424
SGTC_2354 9060492 162 µM 0.161664056337317 0.443050857558167 no 1478 0.435785205512462 2095 6471895
SGTC_958 1222-0007 33 µM 0.161102475068466 0.443274143630504 no 1479 0.436006345443605 2075 7312461
SGTC_3318 9139014 38.6185 µM 0.160961559341284 0.443330174894813 no 1480 0.436061838496666 1992 16643984
SGTC_2832 7992762 51.95 µM 0.160610919901502 0.443469601942251 no 1481 0.436199926862559 1819 2985177
SGTC_22 0964-0034 14.468 µM 0.16048635947153 0.443519133404072 no 1482 0.436248982961165 2025 138402
SGTC_1126 isoteolin 1.0172 µM 0.160196015427477 0.44363459215363 no 1483 0.436363334044444 2026 133323
SGTC_710 3448-4187 58 µM 0.159604427471739 0.443869858911333 no 1484 0.436596345538722 2033 3946412
SGTC_977 1348-1378 135 µM 0.159538170136248 0.443896209816618 no 1485 0.43662244399458 2103 X977
SGTC_1327 1436-0082 2.18 µM 0.159487371713729 0.443916412795523 no 1486 0.43664245344346 2002 15992205
SGTC_1101 ebselen 5.29 µM 0.158360511459922 0.444364612401127 no 1487 0.437086364186739 2153 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2111 5486399 200 µM 0.157387446179856 0.444751698564389 no 1488 0.437469753326165 2068 689674
SGTC_413 propylparaben 100 µM 0.157242184621014 0.444809488260301 no 1489 0.437526991638022 1989 7175 A pharmaceutical preservative.
SGTC_1368 1852-0141 284 µM 0.156062377955763 0.445278896450011 no 1490 0.437991926494711 2021 2838987
SGTC_3302 9125395 16.351 µM 0.15567023258165 0.445434935858501 no 1491 0.438146481017339 2032 17599668
SGTC_1420 4'-methoxyflavone 42 µM 0.155284981148916 0.445588240315962 no 1492 0.43829832764924 2130 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1914 st062367 72.6 µM 0.155251960910979 0.445601380554257 no 1493 0.438311342980132 2012 978205
SGTC_353 1988-1175 58.3 µM 0.154440156720504 0.445924452724414 no 1494 0.438631346487218 1966 2788357
SGTC_3123 9126162 49.47 µM 0.153276652855157 0.446387552702882 no 1495 0.439090055712074 2037 25239884
SGTC_261 5-fluorouridine 15.376 µM 0.153262358519212 0.446393242617182 no 1496 0.439095691737284 2126 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1146 3579-1023 7 µM 0.152585957060034 0.446662499365381 no 1497 0.439362399976378 2140 X1146
SGTC_2117 5521686 200 µM 0.150029042011829 0.44768055781831 no 1498 0.440370851181319 2027 803312
SGTC_2164 5685496 200 µM 0.149261649184498 0.447986169661707 no 1499 0.440673587868694 2124 759046
SGTC_2712 st079126 47.7 µM 0.147581126128196 0.448655540420573 no 1500 0.441336675572388 2076 3152970
SGTC_1417 3966-0327 90.4 µM 0.146148772218672 0.449226178163356 no 1501 0.441901972532966 2057 651118
SGTC_1910 st062352 60.4 µM 0.1460479396075 0.449266352997976 no 1502 0.441941771896813 2075 2245730
SGTC_2131 toluylene red 5.2905 µM 0.144849156713186 0.449744024959854 no 1503 0.442414985005739 2024 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2295 7971645 200 µM 0.14403769914471 0.450067403056068 no 1504 0.442735350202776 2077 2978226 YKL099C UTP11
SGTC_1677 st019204 53.9 µM 0.143360127189681 0.450337451125258 no 1505 0.443002885768382 1960 3945625
SGTC_81 0411-0046 9.971 µM 0.141362118481418 0.451133896115635 no 1506 0.44379193938751 2099 12925265
SGTC_980 1473-0395 201 µM 0.140510521136817 0.451473419313713 no 1507 0.444128320146264 2033 768876
SGTC_2139 5578692 56.4705 µM 0.140076517519575 0.451646465813093 no 1508 0.44429976697672 2181 650991 YMR113W FOL3
SGTC_1578 josamycin 24.2 µM 0.138915459482224 0.452109449497714 no 1509 0.444758477258259 1984 5282165 A P450 substrate.
SGTC_636 0kpi-0074 126 µM 0.137966279310191 0.452487993149831 no 1510 0.44513353392581 2058 616434
SGTC_515 4092-1064 102 µM 0.137666232750688 0.45260766406902 no 1511 0.445252103802544 2173 717353
SGTC_3120 9124077 49.47 µM 0.135819068955701 0.45334448345289 no 1512 0.445982157952133 2193 18774327 YGL155W CDC43
SGTC_3231 9132313 49.47 µM 0.134545746828743 0.453852495514957 no 1513 0.446485519588548 2081 4905967
SGTC_544 k015-0020 52.4 µM 0.133065376032205 0.454443207803751 no 1514 0.447070838757593 2071 3008304
SGTC_1021 4476-0760 85.3 µM 0.133029650200709 0.454457464731148 no 1515 0.447084965712173 1969 746768
SGTC_767 0929-0023 86 µM 0.131161253129315 0.455203157866363 no 1516 0.447823873313347 2176 1204563
SGTC_1135 dihydrocapsaicin 536.708 nM 0.130164505054428 0.455601033227545 no 1517 0.448218138240386 2072 107982 A Capsaicinoid.
SGTC_3054 9094397 49.47 µM 0.129858598713621 0.455723151864535 no 1518 0.44833915014675 2103 2598354
SGTC_2237 6667747 47.222 µM 0.129288161179193 0.45595088323282 no 1519 0.448564819410732 2015 729940 YDL015C TSC13
SGTC_363 0455-0021 3.06 µM 0.127914921994252 0.456499170111932 no 1520 0.449108151006928 2116 4597466
SGTC_2419 paclitaxel 166.5 µM 0.127519795629321 0.456656945785963 no 1521 0.449264503217667 2027 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2028 5153890 36.43 µM 0.12659216442976 0.457027379762555 no 1522 0.449631599462076 2103 2830968 YPR165W RHO1
SGTC_1979 st071809 45.3 µM 0.126570272906624 0.457036122227805 no 1523 0.449640263228541 2136 4976333
SGTC_992 3909-8734 162 µM 0.126462322653598 0.457079232886887 no 1524 0.449682985859565 2062 4288319
SGTC_855 0428-0020 25 µM 0.124896588046219 0.457704576064526 no 1525 0.450302709782971 2052 6812414
SGTC_2480 5767542 37.17 µM 0.124829044081716 0.457731555007057 no 1526 0.450329446687871 2133 2867358
SGTC_3103 9120822 49.47 µM 0.122680289956891 0.458589928303311 no 1527 0.451180136143432 2176 17141819
SGTC_826 1683-5028 118 µM 0.121890272719471 0.458905569113618 no 1528 0.451492959714499 2088 722377
SGTC_2077 5212015 200 µM 0.118564226639074 0.460234728143288 no 1529 0.452810304193561 2205 780900
SGTC_3356 9151811 4.48 µM 0.118400058104543 0.460300345027363 no 1530 0.452875339871221 2121 1859254 YPR165W RHO1
SGTC_596 1155-0152 116 µM 0.118080524407108 0.460428063254895 no 1531 0.453001927377328 2149 280313
SGTC_1539 benzyladenosine 56 µM 0.118048379796975 0.460440911743027 no 1532 0.453014662154977 2154 92208 A nucleotide analog.
SGTC_2947 9072639 7.68 µM 0.116814464360768 0.460934149875387 no 1533 0.453503540662977 2103 16488146
SGTC_1959 st077091 55.8 µM 0.116066862250723 0.461233021255367 no 1534 0.453799775683575 2176 821356 YKL052C ASK1
SGTC_956 1185-0240 191 µM 0.115730293420869 0.461367579653016 no 1535 0.453933148441145 2119 1416193
SGTC_177 1327-0068 8.361 µM 0.11571215705446 0.461374830599926 no 1536 0.453940335520516 2209 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1492 4158-0558 28.5 µM 0.115094970807718 0.461621590238732 no 1537 0.454184923064219 2186 3967268
SGTC_1856 st057054 55.7 µM 0.114954712583071 0.461677669489948 no 1538 0.454240509059957 2210 1266018
SGTC_2446 5162541 200 µM 0.114731263467116 0.461767012413134 no 1539 0.454329066442111 2124 1549321
SGTC_2124 5246320 200 µM 0.114540254966011 0.461843385951608 no 1540 0.454404768755665 2123 579342
SGTC_1686 st019653 115.5 µM 0.114298525276462 0.461940042052497 no 1541 0.454500575749083 2208 97252
SGTC_2462 5162487 171.77 µM 0.114162998307728 0.461994233766364 no 1542 0.454554291581254 2216 2259986
SGTC_91 0417-1751 58.384 µM 0.113807517647706 0.462136379351029 no 1543 0.454695189547905 2215 6795624
SGTC_1527 coumarin 137 µM 0.113666726770241 0.462192678552301 no 1544 0.454750994859258 2138 323 A hepatotoxic, DNA x-linker.
SGTC_2156 5649887 115 µM 0.113563651914239 0.462233896419518 no 1545 0.454791851229128 2182 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_516 3992-2719 87.3 µM 0.11233301371061 0.462726038735046 no 1546 0.45527968314903 2181 5350887 YDR037W KRS1
SGTC_2400 5203494 178.7 µM 0.110821314540645 0.463330657658487 no 1547 0.455879021450799 2207 6777674
SGTC_2229 7354935 190 µM 0.109875171397427 0.463709120088351 no 1548 0.456254186827907 2202 318112
SGTC_1279 0874-0590 65.2 µM 0.10866903027524 0.464191630708986 no 1549 0.456732503304376 2139 3523074
SGTC_1275 0867-0008 21.1 µM 0.107779558850941 0.464547493010157 no 1550 0.457085279047433 2148 3422836
SGTC_2830 7992007 71.43 µM 0.106894697730028 0.464901538948922 no 1551 0.457436259844291 2121 1952075
SGTC_1173 0443-0020 122 µM 0.106860306828858 0.464915299816711 no 1552 0.457449901691853 2110 5331295
SGTC_879 0831-1030 162 µM 0.106504945614243 0.465057493330562 no 1553 0.457590865848284 2194 1549252
SGTC_3135 9127742 49.47 µM 0.10619242657988 0.465182547749676 no 1554 0.457714839842375 2068 3643468
SGTC_2985 9022375 71.43 µM 0.10300967927777 0.466456317039574 no 1555 0.458977644434929 2131 4939335
SGTC_1342 1486-1464 234 µM 0.102895576754506 0.46650198854053 no 1556 0.459022924153364 2228 3253938
SGTC_486 niguldipine 82 µM 0.102077356933088 0.466829508008903 no 1557 0.459347636834115 2239 1236 A calcium channel blocker.
SGTC_2511 berberine 10.47 µM 0.100822836586788 0.467331714696199 no 1558 0.459845549118211 2161 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1590 st077108 57.8 µM 0.100819436657096 0.467333075819223 no 1559 0.459846898617691 2224 5489485
SGTC_3273 9137859 49.47 µM 0.100136482704842 0.467606496357804 no 1560 0.460117985935476 2266 2377234
SGTC_1237 0330-0133 46.1 µM 0.0996558339666316 0.467798933197526 no 1561 0.460308782654958 2179 X1237 YHR072W ERG7
SGTC_329 k048-0121 21.3 µM 0.0990919267318936 0.46802471374609 no 1562 0.46053264103729 2131 6832902
SGTC_1903 st060211 78.3 µM 0.099019394557204 0.468053755359779 no 1563 0.460561435575016 2228 688960
SGTC_1562 morin hydrate 59.1 µM 0.0981054025912941 0.468419728871607 no 1564 0.460924298788358 2145 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1038 k292-0204 154 µM 0.0979657468526307 0.468475651088092 no 1565 0.460979746273756 2228 4454212
SGTC_2872 9044037 25.97 µM 0.0929659784420772 0.470478105023754 no 1566 0.462965294702947 2160 6465195
SGTC_3239 9133757 49.47 µM 0.092607888417943 0.470621552680232 no 1567 0.463107538316042 2230 17036923
SGTC_2023 5144124 124 µM 0.0924531372734548 0.47068354578352 no 1568 0.463169011363446 2179 2830192
SGTC_3132 9126706 49.47 µM 0.0911823025755785 0.471192667216374 no 1569 0.463673868433293 2172 850858
SGTC_1319 1306-0155 43.7 µM 0.0905335188761938 0.471452600962982 no 1570 0.463931629548942 2212 3122360
SGTC_722 3534-0461 190 µM 0.0874827023307187 0.472675065051243 no 1571 0.465143917126598 2160 658262
SGTC_1627 st003713 25.6 µM 0.087116127057625 0.472821969542349 no 1572 0.46528960329129 2151 16195070 YER133W GLC7
SGTC_760 0568-0725 82.9 µM 0.0867125982904345 0.472983687364605 no 1573 0.465449981075941 2258 3916171
SGTC_2152 5568786 200 µM 0.0865393798171141 0.47305310761025 no 1574 0.46551882645342 2243 5399883
SGTC_1588 farnesol 29.9 µM 0.0855973463086694 0.473430657815429 no 1575 0.465893254028797 2234 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.0841926231504615 0.473993689997856 no 1576 0.466451641619297 2160 75037 A free radical scavenger.
SGTC_2074 5212007 75.395 µM 0.0837308738257956 0.474178776818978 no 1577 0.466635204783415 2264 758611
SGTC_2463 5473429 200 µM 0.0825420455300356 0.474655330300975 no 1578 0.467107842443446 2172 5399405
SGTC_1818 st052136 56.3 µM 0.0819571240774238 0.474889815155363 no 1579 0.467340404366368 2187 674169
SGTC_920 mycophenolic acid 780.421 nM 0.0818412994402174 0.474936248275647 no 1580 0.467386457003365 2196 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3286 9117135 37.221 µM 0.0816555599884556 0.475010710365907 no 1581 0.467460309141221 2167 3438150
SGTC_1484 3473-2379 286 µM 0.0813563024743765 0.475130683159193 no 1582 0.467579299718626 2268 671917
SGTC_2038 4100038 30.985 µM 0.0808288514066628 0.475342144578872 no 1583 0.467789031514235 2188 3596803
SGTC_2005 4024620 188 µM 0.079402017743946 0.475914213839838 no 1584 0.468356431891597 2250 236743
SGTC_2966 9084041 48.03 µM 0.0772093900032664 0.476793414030297 no 1585 0.469228485902582 2234 17741380
SGTC_1367 1812-0510 76.9 µM 0.0767886039150281 0.476962153950263 no 1586 0.469395858364073 2229 1142582 YDR527W RBA50
SGTC_2505 galangin 7.89 µM 0.0766542653423011 0.477016026089328 no 1587 0.469449294202489 2190 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1796 st049173 110.4 µM 0.0762600832303394 0.477174102495362 no 1588 0.469606091147788 2277 94134
SGTC_1349 flufenamic acid 69 µM 0.0762123367528355 0.477193250213287 no 1589 0.469625083963391 2245 3371 A non-steroidal anti-inflammatory.
SGTC_1314 1222-0010 41.1 µM 0.0761579883049861 0.477215045576272 no 1590 0.46964670302553 2193 3526027
SGTC_2506 ethyl hematommate 54.16 µM 0.0760684684711713 0.477250945871927 no 1591 0.469682312974429 2080 3940691 An allergen.
SGTC_592 k241-0073 46.5 µM 0.0753544700541354 0.477537288491315 no 1592 0.469966341898328 2275 4230158
SGTC_144 4161-2749 112.381 µM 0.074672074125607 0.477810968058553 no 1593 0.47023781362101 2207 797501 YMR168C CEP3
SGTC_1626 st003712 1.76 µM 0.0745911304537242 0.477843431770058 no 1594 0.470270015668346 2213 24207035
SGTC_123 0083-0120 66.675 µM 0.0742159418272919 0.477993908888134 no 1595 0.470419280544674 2186 16001701
SGTC_2552 juarezic acid 87.02 µM 0.0731084711975518 0.478438100986778 no 1596 0.470859900329561 2294 1549512
SGTC_1129 3453-1384 223 µM 0.0721890551653383 0.478806887198615 no 1597 0.471225727580964 2202 1084452
SGTC_1396 3511-0007 98.6 µM 0.0717978701582466 0.478963800617321 no 1598 0.471381383907678 2220 X1396
SGTC_2043 5101342 149 µM 0.0714761225391808 0.479092863526995 no 1599 0.471509413698723 2212 678451
SGTC_2803 7707263 71.43 µM 0.0712190372592676 0.479195989951104 no 1600 0.471611715172961 2221 2199229
SGTC_820 1582-0060 59.9 µM 0.0702945671271742 0.479566840608048 no 1601 0.471979603308355 2209 3848840
SGTC_3096 9117468 49.47 µM 0.0659672864694191 0.481302956682202 no 1602 0.47370193515889 2290 41316311
SGTC_2293 7624732 200 µM 0.0643817870754467 0.481939153619323 no 1603 0.474333115872611 2292 894453
SGTC_2971 9092186 9.93 µM 0.0614416146043861 0.483119046722194 no 1604 0.475503755641329 2108 25236400
SGTC_13 0199-0087 65 µM 0.0613631203288254 0.483150548597683 no 1605 0.475535011350111 2301 4589825
SGTC_2665 lovastatin 100 µM 0.0612802597442272 0.483183802905186 no 1606 0.475568005846899 2256 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_825 1988-2224 89.6 µM 0.0609397488508587 0.483320460829662 no 1607 0.475703596624719 2250 1180859
SGTC_2815 7968870 71.43 µM 0.0588995898764416 0.484139282432929 no 1608 0.476516042358711 2287 2977326 YHR190W ERG9
SGTC_941 3237-0776 460 µM 0.0586783748414441 0.484228071580545 no 1609 0.476604142014865 2286 760008
SGTC_1824 st053723 68.6 µM 0.0586531310279544 0.484238203747639 no 1610 0.476614195524057 2235 675225
SGTC_2343 7990716 14.84 µM 0.0578240236377894 0.484570990093013 no 1611 0.476944401048144 2265 6456862
SGTC_2108 5365811 200 µM 0.0572978854029155 0.484782176552028 no 1612 0.477153952395836 2264 780283
SGTC_457 grayanotoxin iii 135 µM 0.0569431980237503 0.484924546818944 no 1613 0.477295221535495 2243 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1406 3909-7906 11.9 µM 0.0564182587321433 0.485135259126494 no 1614 0.477504305878109 2306 X1406
SGTC_2868 9035608 32.47 µM 0.0562430786117705 0.485205577912702 no 1615 0.477574081842256 2307 6462614
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.0558297226803044 0.485371504309339 no 1616 0.4777387282946 2241 5282362
SGTC_429 1112-0049 25.5 µM 0.0557060989042543 0.485421128979163 no 1617 0.477787970413162 2176 2836170
SGTC_2479 5617353 43.85 µM 0.0556124440571035 0.485458723765566 no 1618 0.477825275461993 2293 2731746
SGTC_3180 9109287 49.47 µM 0.0555121680471033 0.485498976552365 no 1619 0.477865218099613 2268 18891271
SGTC_2700 st077718 96.8 µM 0.0553785036574621 0.485552632329155 no 1620 0.47791846057444 2248 904970
SGTC_791 1348-1292 225 µM 0.0551421492883512 0.485647510724185 no 1621 0.478012608465538 2276 5437054
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.0537221337288306 0.486217556439388 no 1622 0.478578274049174 2284 4620898
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.0527778345116294 0.486596648035645 no 1623 0.478954461189287 2312 6312947
SGTC_1629 st005085 44.9 µM 0.052356479882009 0.486765805973996 no 1624 0.47912232527463 2263 24207091
SGTC_2560 caryophyllene 100 µM 0.0512235640182822 0.48722064054338 no 1625 0.479573687559222 2325 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2880 9042983 58.44 µM 0.0505986011589357 0.487471553099874 no 1626 0.479822688756381 2260 6464714
SGTC_2153 5569715 200 µM 0.0502158827668815 0.487625210845834 no 1627 0.479975177451913 2318 2054701
SGTC_2940 9060638 45.86 µM 0.0502008864605813 0.487631231755836 no 1628 0.479981152576506 2242 4027022
SGTC_698 k064-0052 127 µM 0.0496214104640178 0.487863889380646 no 1629 0.48021204228231 2316 5088751
SGTC_2792 7535235 81.82 µM 0.0488717291382751 0.488164889977806 no 1630 0.480510759405216 2261 1281891
SGTC_2430 5571206 200 µM 0.0454908233351131 0.489522420908984 no 1631 0.481858044622835 2324 1731771
SGTC_2151 5563267 85.4165 µM 0.0453980223759717 0.489559684947056 no 1632 0.481895028639747 2254 5310824
SGTC_1782 st039423 80.636 µM 0.0434650145223992 0.490335900584471 no 1633 0.482665426261609 2254 2068169
SGTC_925 2064-1272 59.6 µM 0.0432766475634741 0.490411542932932 no 1634 0.482740503161516 2221 6815817
SGTC_1290 0986-0249 10.2 µM 0.042734614101432 0.490629208731923 no 1635 0.482956543350406 2335 53329
SGTC_845 0330-0138 4.51 µM 0.0415782414443638 0.491093585578284 no 1636 0.483417459525624 2339 9039800
SGTC_2079 5212404 121 µM 0.0412887017590323 0.49120986101844 no 1637 0.483532870040531 2328 758462
SGTC_479 n-linoleoylglycine 10 µM 0.0397285280512018 0.491836419463708 no 1638 0.484154778765044 2319 6433346 An anti-infammatory.
SGTC_2327 6189656 200 µM 0.0394496503013441 0.491948417626968 no 1639 0.484265947738679 2327 5349088
SGTC_1794 st048918 76.9 µM 0.0382670626489708 0.492423355417369 no 1640 0.484737375870042 2334 672303
SGTC_1440 4100-1550 40 µM 0.0380100223875564 0.492526586532211 no 1641 0.484839845547144 2326 742806
SGTC_276 colchicine 750 µM 0.0375186953105006 0.492723912033404 no 1642 0.485035716969208 2258 2833 A microtubule depolymerizer.
SGTC_317 4495-0002 170 µM 0.0367789022859684 0.493021029124822 no 1643 0.485330648101107 2229 15991618
SGTC_1644 st010134 20.9 µM 0.0363283268550799 0.493201992000101 no 1644 0.485510281639203 2341 3818134
SGTC_1953 st076800 12.1 µM 0.0362881613194058 0.493218123597993 no 1645 0.485526294811127 2171 297591
SGTC_2417 cerulenin 830 nM 0.0360104814039799 0.493329647888447 no 1646 0.485637000712052 2354 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_934 2950-0684 338 µM 0.0357057160567949 0.493452051071995 no 1647 0.485758506352886 2341 1121253
SGTC_1839 st053978 48 µM 0.0356747706415508 0.493464479741934 no 1648 0.485770843927147 2346 3788398
SGTC_374 0880-0231 82.3 µM 0.0355842183508131 0.493500848478669 no 1649 0.485806946142049 2317 6833587
SGTC_3176 9106582 49.47 µM 0.0352404755078896 0.493638907241793 no 1650 0.485943993736863 2334 17018027
SGTC_3296 9122258 64.045 µM 0.0349567843064294 0.493752847807279 no 1651 0.486057100460995 2313 4730474
SGTC_2928 9011484 9.79 µM 0.033611200777024 0.494293289216779 no 1652 0.486593595193722 2312 2994751
SGTC_2138 5575593 77.673 µM 0.0334292371122243 0.494366374096846 no 1653 0.48666614742153 2343 762213
SGTC_2871 9038510 12.99 µM 0.0332421160366302 0.494441530624737 no 1654 0.486740756463215 2356 4945164
SGTC_2543 pimpinellin 60.67 µM 0.0332334278737156 0.494445020199907 no 1655 0.486744220624697 2344 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_545 4218-0007 221 µM 0.0331544838463375 0.494476727856567 no 1656 0.486775697389059 2317 2840508
SGTC_75 0159-0059 199.013 µM 0.0328910590021457 0.494582531989393 no 1657 0.486880731411215 2339 5377270
SGTC_2829 7992743 58.44 µM 0.0326271580975699 0.494688527713175 no 1658 0.486985956162975 2361 16462845
SGTC_2594 a-mangostin 100 µM 0.0317908377691535 0.495024437978344 no 1659 0.487319426672944 2332 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1039 k821-0043 94 µM 0.0302122685893589 0.495658483873868 no 1660 0.487948882039676 2332 15992768
SGTC_284 0988-0104 32.6 µM 0.0295335784163125 0.495931089087251 no 1661 0.488219519455588 2331 4666532
SGTC_1833 st055984 71 µM 0.0267819381546115 0.497036341265354 no 1662 0.48931682965783 2328 676288
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.0265682643991354 0.497122168728469 no 1663 0.489402042830359 2318 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1036 k216-0215 33.5 µM 0.0253298116714686 0.49761962705878 no 1664 0.489895947640117 2363 622330
SGTC_597 k018-0003 82.8 µM 0.0245154464711074 0.497946741127398 no 1665 0.490220731457898 2353 6786234
SGTC_2854 9024559 71.43 µM 0.0242969974393117 0.498034487939522 no 1666 0.490307854060871 2341 3163529
SGTC_1212 0520-0165 585 µM 0.0234150324709254 0.498388757379064 no 1667 0.490659607057977 2355 5403258
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.0232935970628877 0.498437535900668 no 1668 0.490708039566623 2371 1273210
SGTC_55 0767-0285 6.563 µM 0.0232193185561303 0.498467372315013 no 1669 0.49073766439092 2361 3116166
SGTC_1680 diphenhydramine 100 µM 0.0229072512089836 0.498592724558784 no 1670 0.490862128143048 2301 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2846 9008642 19.48 µM 0.0225475528877722 0.498737209541283 no 1671 0.491005589954501 2309 2992898
SGTC_2244 6635614 200 µM 0.0213594127988814 0.499214467221026 no 1672 0.491479475033633 2350 836499
SGTC_2476 5806916 10.51 µM 0.0211985181271009 0.499279096248464 no 1673 0.491543648190561 2342 2870194
SGTC_2557 derrustone 83.84 µM 0.0209634781942891 0.499373508372214 no 1674 0.491637394723935 2265 629853 An antioxidant.
SGTC_802 4112-3352 742 µM 0.0209398036543001 0.499383018092755 no 1675 0.491646837426141 2346 704594
SGTC_804 1595-0054 20.9 µM 0.0202689016220682 0.499652509867694 no 1676 0.491914431799588 2343 761523 Stimulates phospholipase C.
SGTC_2377 9073351 62.6 µM 0.0199501109388471 0.499780563600239 no 1677 0.492041585168667 2362 7337946 YHR072W ERG7
SGTC_253 dyclonine 31.25 µM 0.0195639109033142 0.499935694750298 no 1678 0.492195626623412 2368 3180 An oral anasthetic.
SGTC_262 fenpropimorph 62.5 µM 0.0192437342258233 0.499935694750298 no 1679 0.492323334592896 2371 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1719 st032227 49.2 µM 0.0186754409985472 0.499707419323278 no 1680 0.492550010041157 2367 3125804
SGTC_2455 5377712 9.75 µM 0.0185208147677659 0.499645308146287 no 1681 0.492611686314677 2316 2243908
SGTC_1770 st043884 66.3 µM 0.0179495002057565 0.499415819227392 no 1682 0.492839569954578 2374 670149
SGTC_1975 st070967 30.8 µM 0.0173948186026696 0.499193011715336 no 1683 0.493060821343695 2378 261391
SGTC_1665 st014639 11.4 µM 0.0161669814248779 0.498699808419602 no 1684 0.493550588512874 2377 981133 YIL048W NEO1
SGTC_2650 prasterone 100 µM 0.0150429225555311 0.49824829299677 no 1685 0.49399896850107 2374 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2606 farnesol 9.78 µM 0.014831668770179 0.498163436159721 no 1686 0.49408323716613 2374 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3228 9131799 49.47 µM 0.0148048240123206 0.498152653110322 no 1687 0.494093945499312 2350 17015818
SGTC_629 3448-6466 76.7 µM 0.0146853469131174 0.498104661356137 no 1688 0.494141604784431 2372 573744
SGTC_2261 9010538 184.68 µM 0.0146751008178754 0.498100545689318 no 1689 0.494145691944599 2291 6457250
SGTC_2607 solasodine 47.35 µM 0.014626807176439 0.498081147030125 no 1690 0.494164956252383 2352 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_336 4111-0029 111 µM 0.0142474529912746 0.497928767658096 no 1691 0.49431628090401 2314 3131175
SGTC_205 1486-1330 71.903 µM 0.0133512593771903 0.497568784942825 no 1692 0.494673776376969 2377 4118834
SGTC_911 3456-4043 236 µM 0.0132943595563383 0.497545929507838 no 1693 0.494696474106769 2375 914281
SGTC_368 fentichlor 4.58 µM 0.0117787111433138 0.496937129319708 no 1694 0.495301082769639 2359 7329 A pesticide.
SGTC_3183 9108214 49.47 µM 0.0113438562931361 0.496762459646489 no 1695 0.495474553160148 2384 4974831
SGTC_3332 9141069 11.198 µM 0.0103377299053659 0.496358327766098 no 1696 0.4958759159134 2387 17332883
SGTC_1185 1319-0113 81.3 µM 0.00982965304917982 0.496154249376833 no 1697 0.496078598946094 2374 4672763
SGTC_1556 plumbagin 1.48 µM 0.00978342996697338 0.496135683077107 no 1698 0.496097038401249 2384 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3225 9130819 49.47 µM 0.00947788282921457 0.496012955001648 no 1699 0.496218928419929 2390 4547121
SGTC_2370 9071495 200 µM 0.0082832157890377 0.495533100901336 no 1700 0.496695512791835 2347 21791103
SGTC_186 3455-3465 67.277 µM 0.00827964178825982 0.495531665365157 no 1701 0.496696938562963 2395 755278
SGTC_2988 9073640 71.4286 µM 0.00718791404527501 0.495093163872191 no 1702 0.497132461871892 2385 9102229
SGTC_510 ag-490 170 µM 0.00659229893477714 0.494853932594146 no 1703 0.49737007227863 2389 5328779
SGTC_3223 9129970 49.47 µM 0.00554991432835027 0.49443525900155 no 1704 0.497785915888025 2394 17248386
SGTC_2685 mycophenolic acid 18.85 µM 0.00531284717361512 0.494340041859784 no 1705 0.497880490604139 2392 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2980 9014342 25.29 µM 0.00330423202402933 0.493533302531626 no 1706 0.498681804540024 2385 2996599
SGTC_3112 9123419 49.47 µM 0.00322620720533709 0.493501965189188 no 1707 0.498712931773179 2398 17015854
SGTC_2875 9039966 71.43 µM 0.00293279115568648 0.49338411997984 no 1708 0.498829987285674 2386 6463691
SGTC_972 1319-0219 195 µM 0.00273900464148617 0.493306289473789 no 1709 0.498907296608566 2398 23903702
SGTC_2849 9019321 12.99 µM 0.00265077203242992 0.493270852682349 no 1710 0.498942496199 2394 16489627
SGTC_727 3032-0951 202 µM 0.00195169698956187 0.492990085638082 no 1711 0.499221386046637 2397 3652836
SGTC_1487 3970-0795 2.82 µM 0.00188076318946106 0.492961596937821 no 1712 0.499249684486646 2403 3765103
SGTC_293 4049-0273 38.5 µM 0.000651502897515733 0.492467902611589 no 1713 0.499740087966764 2404 1380311
SGTC_202 3594-0513 34.79 µM 0.000395822242512703 0.492365217819249 no 1714 0.499842089776062 2398 708429
SGTC_1102 cgs 12066b 26.1 µM 0.00027019598248164 0.492314764807315 no 1715 0.499892207399905 2404 6438352 A 5-HT1B full agonist.
SGTC_2521 angolensin 13.4 µM 0.000141091372221292 0.492262914976341 no 1716 0.499943712686408 2403 821428 A flavenoid.
SGTC_2920 7982904 15.77 µM 0 0.492206251279497 no 1717 0.5 2406 6456808
SGTC_474 dl-dihydrosphingosine 5 µM -0.00107144103815205 0.491775955127534 no 1718 0.499572556950707 2413 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1809 st050081 57.6 µM -0.00281915586628155 0.491074084756536 no 1719 0.498875321019656 2414 5036894
SGTC_275 trichlorophene 5.69 µM -0.00317240422075912 0.490932225910613 no 1720 0.498734395948687 2421 62616
SGTC_1672 st016598 6.51 µM -0.00396068381255118 0.490615669693034 no 1721 0.498419919898997 2427 4665860 YNL267W PIK1
SGTC_521 r062-0005 13.8 µM -0.00514652173810672 0.49013947375195 no 1722 0.497946843945218 2417 2832033
SGTC_829 1635-0120 117 µM -0.00521080243971735 0.490113660999987 no 1723 0.497921199999405 2418 285054
SGTC_1848 st056003 16.4 µM -0.00545214561419247 0.490016746879079 no 1724 0.497824919371634 2409 146492
SGTC_1987 st072290 61.9 µM -0.00669642175861229 0.489517102994569 no 1725 0.497328534198778 2437 54697379
SGTC_1363 1636-0063 10.4 µM -0.00707972645977271 0.48936318879143 no 1726 0.497175621375705 2418 6072185
SGTC_1524 corynanthine 62.1 µM -0.00723736450571323 0.489299890432555 no 1727 0.497112734505577 2492 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_914 3820-6779 408 µM -0.00886116081495326 0.488647883343199 no 1728 0.496464954559601 2424 2893481
SGTC_69 0096-0274 206.684 µM -0.00918522278205236 0.488517765487608 no 1729 0.496335677802855 2524 6741392
SGTC_2998 9066762 71.4286 µM -0.00993627770898471 0.488216205488985 no 1730 0.496036063938496 2435 4945196
SGTC_1702 st027038 51 µM -0.0111798411414566 0.487716910714635 no 1731 0.495539981589456 2435 5521182
SGTC_2657 nystatin 74.44 µM -0.0117397441868494 0.487492114053982 no 1732 0.495316627261332 2435 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2174 5790901 200 µM -0.0125081437941724 0.48718361415028 no 1733 0.49501010270612 2437 786020
SGTC_638 3970-0837 4.09 µM -0.0153709340883839 0.486034319548591 no 1734 0.493868125962329 2447 4118451 YLR208W SEC13
SGTC_3291 9121177 71.43 µM -0.0155496600567852 0.485962572043422 no 1735 0.493796833137765 2451 17015612
SGTC_2409 alverine citrate 63.97 µM -0.015692120334184 0.485905383312346 no 1736 0.493740006643484 2579 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2444 5485484 36.41 µM -0.0157263470556735 0.485891643505993 no 1737 0.493726353841886 2446 6790631
SGTC_147 4466-0538 29.23 µM -0.0166085077325647 0.485537519097822 no 1738 0.49337446865306 2485 6742687 YHR072W ERG7
SGTC_1072 oxiconazole 14.9 nM -0.0171980645544616 0.48530086054748 no 1739 0.493139303111788 2435 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_3023 9089636 49.47 µM -0.017233917926597 0.48528646853504 no 1740 0.493125001805291 2434 17249241
SGTC_1813 st051246 8.6015 µM -0.0173142654241327 0.485254216068432 no 1741 0.493092952573418 2438 5291959
SGTC_2752 diclazuril 33.15 µM -0.0176050088365937 0.485137508920126 no 1742 0.492976980411609 2445 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2396 5342950 42.78 µM -0.0176285113451489 0.485128074846978 no 1743 0.492967605722083 2448 1886677
SGTC_35 0133-0054 64.071 µM -0.0184724932696517 0.484789300091132 no 1744 0.49263096050594 2461 99677
SGTC_618 k072-0232 33.2 µM -0.0204789696044411 0.483983944039517 no 1745 0.491830644191623 2450 5872756 YGL099W LSG1
SGTC_3000 9075062 71.4286 µM -0.0208444062828302 0.483837272625299 no 1746 0.491684887166162 2456 17057871
SGTC_2771 fluoxetine 41.05 µM -0.0216510736802326 0.483513516923165 no 1747 0.49136314607969 2468 3386 A selective serotonin reuptake inhibitor.
SGTC_681 1642-0006 26.6 µM -0.0222811256106324 0.483260653331971 no 1748 0.491111852363081 2440 4446530
SGTC_447 ml7 120 µM -0.0224227365663847 0.483203820440087 no 1749 0.491055371876348 2448 4216 Selective myosin light chain kinase inhibitor.
SGTC_564 3555-0129 330 µM -0.0224370799864457 0.483198063997412 no 1750 0.49104965111888 2448 563260
SGTC_3128 9127691 49.47 µM -0.0241111708118894 0.482526225748526 no 1751 0.490381966447174 2517 41316314
SGTC_846 0335-0850 148 µM -0.0243443412166332 0.482432654792579 no 1752 0.490288972211471 2445 6819598
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.0245901765243397 0.482334002476895 no 1753 0.490190927464935 2486 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1613 st002381 52.1 µM -0.0247224247058443 0.482280932478264 no 1754 0.49013818410852 2453 551167
SGTC_1435 4092-0789 56.7 µM -0.0254099969336571 0.482005021045304 no 1755 0.489863968641784 2442 2248285
SGTC_2570 licareol 100 µM -0.0261024675799733 0.48172715266895 no 1756 0.489587804445127 2500 443158
SGTC_1157 4092-0394 27.6 µM -0.02658661479422 0.481532883705523 no 1757 0.489394724666984 2501 3659885
SGTC_3327 9140648 26.9345 µM -0.0266234169102743 0.481518116663225 no 1758 0.489380047942092 2457 8029710
SGTC_1521 st012942 49.4 µM -0.0268694111445408 0.481419410837372 no 1759 0.489281945537623 2522 24207259
SGTC_2910 7948405 25.97 µM -0.0274430922202547 0.481189224250824 no 1760 0.489053164278488 2458 2971328
SGTC_1168 k815-0004 80.5 µM -0.0287742963565323 0.480655109716382 no 1761 0.488522300462698 2457 642433
SGTC_256 clotrimazole 625 nM -0.029002497880719 0.480563552650691 no 1762 0.48843129920644 2444 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.0291164542642424 0.480517832427731 no 1763 0.488385856378176 2470 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2144 5628481 200 µM -0.0292978601370334 0.480445051452978 no 1764 0.48831351676723 2444 2818399
SGTC_1273 0849-0096 14.1 µM -0.029692227446564 0.480286831500193 no 1765 0.488156255394712 2473 5286025
SGTC_493 zm226600 134 µM -0.0298448019488533 0.480225619523652 no 1766 0.488095413938638 2502 5240098 A potassium channel opener. YCR052W RSC6
SGTC_553 k007-0256 45.7 µM -0.0311081741094474 0.47971878022989 no 1767 0.487591635414576 2480 6287000
SGTC_1880 MG-132 525 µM -0.0315360016019806 0.479547151905971 no 1768 0.487421040643892 2480 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_3227 9130768 49.47 µM -0.0330786319539889 0.478928338254345 no 1769 0.48680594132705 2476 17720899
SGTC_1870 st057514 26.5 µM -0.0333123135573433 0.47883460316767 no 1770 0.486712767205795 2462 5393161
SGTC_1292 0kpi-0043 232 µM -0.0335631528046297 0.478733987056711 no 1771 0.486612752752542 2477 3333905
SGTC_2420 aureobasidin a 50 nM -0.0339510901886858 0.478578381100714 no 1772 0.486458076284237 2524 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2956 9076196 2.52 µM -0.0357535200840018 0.477855449830544 no 1773 0.485739447474481 2467 16423868
SGTC_274 sirtinol 40.1 µM -0.0359586090048476 0.477773195894912 no 1774 0.485657681411325 2491 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_3137 9097352 49.47 µM -0.0367798983291424 0.477443815224571 no 1775 0.485330251006043 2504 44120435
SGTC_1301 naphtanilide LB 4.81 µM -0.0384407200821464 0.47677778474677 no 1776 0.484668147514641 2482 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_421 streptovitacin 30 mM -0.0397773668137305 0.476241803468135 no 1777 0.484135310306801 2634 91467 include heat shock
SGTC_1933 st074711 15.9 µM -0.040550003634101 0.475932003772262 no 1778 0.483827321331458 2469 17250958
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.0411315295335008 0.475698842297293 no 1779 0.483595519466009 2465 91467 include heat shock
SGTC_693 4161-2696 114 µM -0.0418836722019362 0.475397284773124 no 1780 0.483295716335556 2525 805759
SGTC_949 1165-0505 146 µM -0.0434231237501223 0.474780114617894 no 1781 0.482682122498259 2488 6244267
SGTC_741 4582-0002 126 µM -0.0445406064493771 0.474332150700238 no 1782 0.482236742406068 2493 2912688
SGTC_3199 9111318 49.47 µM -0.0476071525429489 0.47310303652727 no 1783 0.481014665795056 2532 8548020
SGTC_330 1488-0319 80.1 µM -0.0478230516421378 0.473016510687533 no 1784 0.480928632509344 2544 6846614
SGTC_265 mycophenolic acid 32.932 µM -0.0478430514526826 0.473008495431745 no 1785 0.480920662861815 2526 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_552 k242-0005 476 µM -0.0485765257640182 0.472714551012708 no 1786 0.480628388800714 2549 4088318
SGTC_1714 st033236 13.627 µM -0.0495716950655789 0.472315754475741 no 1787 0.480231851478234 2538 2916566
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.0505030683177388 0.471942548211813 no 1788 0.479860752181416 2544 5379071
SGTC_3201 9113999 49.47 µM -0.0507235839757235 0.471854189997902 no 1789 0.479772891770628 2584 16649224
SGTC_3069 9117009 49.47 µM -0.0509373064069881 0.471768555077529 no 1790 0.479687738933922 2487 41904981
SGTC_187 1488-2104 32.728 µM -0.0513373915225945 0.471608251330644 no 1791 0.479528336623714 2558 2852859
SGTC_1259 0671-0132 43 µM -0.0513521524518989 0.47160233709628 no 1792 0.479522455622028 2526 X1259
SGTC_1109 tnp00067 928.257 nM -0.0522379716025397 0.471247429079175 no 1793 0.479169538629436 2518 676295
SGTC_2322 7413319 38.22 µM -0.0527565151843479 0.471039682492582 no 1794 0.478962954537762 2571 1840400
SGTC_1655 st012546 55.1 µM -0.0528487938286179 0.471002713283901 no 1795 0.478926191969968 2558 720985 YLR208W SEC13
SGTC_2013 4024628 200 µM -0.0528736903501819 0.470992739137015 no 1796 0.478916273562124 2573 5230760
SGTC_1502 4534-4282 27.7 µM -0.0529420242864551 0.470965363007887 no 1797 0.478889050394549 2514 3278949
SGTC_1673 st016611 27.3 µM -0.0538670569666358 0.470594787429453 no 1798 0.47852054163743 2652 5226799
SGTC_483 fpl-64176 144 µM -0.0543778875603474 0.470390155451887 no 1799 0.478317047977139 2509 3423
SGTC_2516 gossypol 71.55 µM -0.0553642830414522 0.469995040645205 no 1800 0.477924125089084 2542 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.055495251113023 0.469942581725577 no 1801 0.477871956592365 2493 17037758
SGTC_1000 4048-0884 8.67 µM -0.0603607396269517 0.467994100421065 no 1802 0.475934163426977 2584 13040088
SGTC_1497 4476-2978 41.3 µM -0.0611621531504212 0.467673230774131 no 1803 0.475615035343974 2587 1528379
SGTC_2927 9011802 47.9 µM -0.0613846788593231 0.467584139730646 no 1804 0.475526426923744 2569 43912568
SGTC_686 1319-0111 510 µM -0.0666428184941328 0.465479457805361 no 1805 0.473433028632668 2550 4562600
SGTC_1466 k213-0079 57.5 µM -0.0666971167671656 0.46545772870396 no 1806 0.473411414844619 2518 3657981
SGTC_1418 3966-3099 2.4 µM -0.0669274211671211 0.465365566556293 no 1807 0.473319741520151 2528 740335
SGTC_1410 3909-8106 77.9 µM -0.0681840914347528 0.464862710923705 no 1808 0.472819545346664 2565 1039210
SGTC_381 3461-2219 42.7 µM -0.0685244644969529 0.464726520530422 no 1809 0.472684072995888 2559 2883159
SGTC_1883 5-benzylidenerhodanine 20 µM -0.0688023437008171 0.464615338302223 no 1810 0.472573476253701 2558 1273210
SGTC_1756 st041558 35.5 µM -0.0688048280218319 0.464614344313169 no 1811 0.472572487496138 2555 3955792
SGTC_870 0573-2213 57.6 µM -0.0695944115010827 0.464298439301816 no 1812 0.472258242566599 2526 3916321
SGTC_2914 7968218 45.32 µM -0.069919568282055 0.46416835362665 no 1813 0.4721288390041 2595 2977111
SGTC_122 0236-0016 402.397 µM -0.0699543068127688 0.464154455987332 no 1814 0.472115014186618 2527 6808838
SGTC_142 0335-0849 62.6745 µM -0.0709504459211967 0.463755955157826 no 1815 0.471718597232442 2545 3889043 YPR107C YTH1
SGTC_606 k015-0008 38.6 µM -0.0711919167176604 0.463659361346025 no 1816 0.471622507309713 2563 1970475
SGTC_309 k408-0051 1.48 µM -0.07153216466777 0.463523258062959 no 1817 0.471487113206533 2546 3640463
SGTC_659 k018-0002 107 µM -0.0733045809820214 0.462814339566526 no 1818 0.470781873206739 2560 6797879 YHR007C ERG11
SGTC_1617 st002906 78 µM -0.0736917703128068 0.462659489964482 no 1819 0.470627823661978 2543 5150859
SGTC_2999 9069765 71.4286 µM -0.0747410874922894 0.462239862422463 no 1820 0.470210357994064 2592 2097066
SGTC_1222 0366-0074 1.18 µM -0.0767836822203562 0.461423138827591 no 1821 0.469397816056268 2588 286520
SGTC_579 4491-1009 110 µM -0.0771826585671061 0.461263628561947 no 1822 0.469239118474486 2529 1271041
SGTC_1041 0206-0046 107 µM -0.0776605101752763 0.461072592264705 no 1823 0.46904905375413 2645 50494
SGTC_2747 doxorubicin 7.63 µM -0.0779351589191291 0.460962796803186 no 1824 0.46893981584041 2529 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2406 ethylparaben 405.7 µM -0.0785009462701969 0.460736623168044 no 1825 0.468714788766278 2556 8434 A possible steroid mimic.
SGTC_1462 k081-0014 26.5 µM -0.0789450120393619 0.460559116658366 no 1826 0.468538180254491 2516 3270634
SGTC_2222 6885208 172.143 µM -0.079359252042683 0.460393539493128 no 1827 0.468373439269311 2558 609514
SGTC_975 1335-0046 28.5 µM -0.0805738243286219 0.459908098704865 no 1828 0.467890441831996 2582 16486740
SGTC_2514 salinomycin 42.74 µM -0.080591945469341 0.459900856489975 no 1829 0.467883235976792 2622 23682228 A polyether potassium ionophore.
SGTC_888 0916-0002 6.97 µM -0.0808937121698703 0.459780255703498 no 1830 0.467763240270067 2724 2802138 YIL048W NEO1
SGTC_3326 9140064 16.379 µM -0.0811340972394642 0.45968418867725 no 1831 0.467667654693854 2549 1868434
SGTC_3207 9114163 49.47 µM -0.0859024795225583 0.457779055216093 no 1832 0.465771970212617 2613 849233
SGTC_766 1391-0721 126 µM -0.0864239672644014 0.457570760882927 no 1833 0.465564697542457 2647 1020919 YIL115C NUP159
SGTC_3197 9113331 49.47 µM -0.0871150046703899 0.457294762432872 no 1834 0.46529004936315 2659 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2776 terbinafine 19.92 µM -0.0882960767683461 0.456823093220393 no 1835 0.464820678532014 2539 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2759 disulfiram 3.38 µM -0.0885359019769797 0.456727324792214 no 1836 0.464725375356488 2577 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2617 dihydrotanshinone i 20.83 µM -0.0885788223861815 0.456710185824218 no 1837 0.464708319600944 2589 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1 0258-0098 57.368 µM -0.0895282731695769 0.456331072005412 no 1838 0.464331042528749 2580 6790032 YDR047W HEM12
SGTC_56 0957-0365 83.25 µM -0.0913057050441676 0.455621454102405 no 1839 0.463624842478472 2544 6752360
SGTC_1023 4482-3888 16 µM -0.0925513612357645 0.455124225355118 no 1840 0.463129992963268 2632 3303168
SGTC_1778 st046819 58.9 µM -0.0943915610796449 0.454389801392013 no 1841 0.462399059579431 2581 671715
SGTC_1321 1326-2144 215 µM -0.0947864936236639 0.454232204004069 no 1842 0.462242207546743 2678 3513030
SGTC_228 caffeine 993.056 µM -0.0959016670859488 0.453787234264872 no 1843 0.461799335270954 2644 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1247 0448-0043 5.84 µM -0.0962434819957774 0.453650856944739 no 1844 0.461663598719774 2656 3089013 YGL099W LSG1
SGTC_1808 st050063 61.5 µM -0.0967881116826276 0.453433571878549 no 1845 0.461447332554641 2574 4011993
SGTC_2313 7726885 200 µM -0.0977467386653272 0.453051152650883 no 1846 0.46106670057058 2665 726423
SGTC_946 3434-1334 87.4 µM -0.0983382734411525 0.452815196982207 no 1847 0.46083184381909 2692 4047976
SGTC_2309 7664088 163.95 µM -0.0985557845435526 0.452728438765849 no 1848 0.460745488927549 2610 704922
SGTC_210 3551-0445 56.827 µM -0.0989376512185675 0.452576129833731 no 1849 0.460593887099269 2709 2865180 YOR207C RET1
SGTC_2788 5282734 71.43 µM -0.100056271350378 0.452130004308096 no 1850 0.460149825729947 2674 743706
SGTC_803 4488-1585 147 µM -0.100187782986336 0.452077559097275 no 1851 0.460097622488482 2616 747204
SGTC_1433 4060-0023 7.6 µM -0.100466243456484 0.451966515273194 no 1852 0.459987090516349 2672 3840627
SGTC_1745 st081495 74 µM -0.101021580495893 0.451745070477423 no 1853 0.459766664526012 2610 13842402 YBL026W LSM2
SGTC_543 3844-1095 191 µM -0.101063557625797 0.451728332392538 no 1854 0.459750003343551 2687 4230703
SGTC_80 0159-0065 512.242 µM -0.101684234090877 0.451480852054276 no 1855 0.45950365832359 2567 1548079
SGTC_1412 3909-8563 178 µM -0.10200104849533 0.451354536924558 no 1856 0.459377921423619 2612 23767530
SGTC_1892 st058411 7.36 µM -0.102830887112951 0.451023700433865 no 1857 0.459048595414783 2685 3934738
SGTC_1643 st009866 20.2 µM -0.10382326544466 0.45062810799619 no 1858 0.458654801544233 2601 3156273 YOR207C RET1
SGTC_3189 9110682 49.47 µM -0.104391602170456 0.450401573607633 no 1859 0.458429293384182 2664 17122418
SGTC_823 0417-1665 178 µM -0.104568198520874 0.450331187028036 no 1860 0.458359225113454 2671 3429856
SGTC_1288 0973-0013 65.5 µM -0.104669394311593 0.45029085379779 no 1861 0.458319074164216 2667 4315430
SGTC_784 4579-0127 173 µM -0.104825069645607 0.450228807860956 no 1862 0.458257308468748 2797 1948547
SGTC_2253 7938677 135.83 µM -0.105301288183695 0.450039013833528 no 1863 0.458068370418631 2794 2301972
SGTC_2133 5320837 200 µM -0.107128986177796 0.449310702275591 no 1864 0.457343325921187 2689 2841355
SGTC_1763 st044482 94.5 µM -0.10797746816856 0.448972652197324 no 1865 0.457006782745676 2719 88505
SGTC_673 1082-0474 110 µM -0.109243913924108 0.448468147013619 no 1866 0.456504515219719 2610 3098046
SGTC_1780 st038448 24.544 µM -0.109268745110364 0.448458256016977 no 1867 0.456494667958502 2804 728868 YDL195W SEC31
SGTC_2676 harmalol 100 µM -0.109998711640285 0.448167503077087 no 1868 0.456205198338684 2599 5459187 A monoamine oxidase inhibitor
SGTC_2365 9042475 200 µM -0.110893174406184 0.447811267624002 no 1869 0.455850529126938 2656 6464479
SGTC_497 capsazepine 133 µM -0.113724763393065 0.446683816612132 no 1870 0.454727990761931 2616 2733484 A calcium channel blocker.
SGTC_1503 4585-0012 61.3 µM -0.115183582030743 0.446103127800345 no 1871 0.454149805849422 2805 2922052
SGTC_260 nsc-65238 3.989 µM -0.116200756340915 0.44569830565887 no 1872 0.453746718670649 2676 3246252
SGTC_2356 9061756 188.97 µM -0.117170778587192 0.445312302149466 no 1873 0.453362361347288 2644 20104043
SGTC_1392 3455-1037 33.9 µM -0.117327150562368 0.445250081479765 no 1874 0.453300405286852 2745 981132
SGTC_2398 5228213 48.84 µM -0.117749503429819 0.445082033314504 no 1875 0.453133070758301 2653 80771 YMR134W ERG29
SGTC_2492 derrusnin 100 µM -0.118003922611531 0.444980808321878 no 1876 0.453032274903394 2600 1715307 Part of coumarin class of compounds.
SGTC_1654 st012436 41.8 µM -0.118663492888413 0.444718403806646 no 1877 0.452770980293818 2615 4323132
SGTC_2126 5251174 33.877 µM -0.120404896049995 0.44402571783957 no 1878 0.452081206566521 2672 790722
SGTC_850 0388-0143 75.9 µM -0.120988844881849 0.443793475990034 no 1879 0.451849935389658 2635 67273
SGTC_1602 st001878 87.6 µM -0.122297754686327 0.44327298069729 no 1880 0.451331605076269 2822 595405 YLR310C CDC25
SGTC_2078 5212016 200 µM -0.122830574165904 0.443061130032413 no 1881 0.45112063144671 2585 1899708
SGTC_1151 3909-8316 15.3 µM -0.125241194866179 0.442102864096865 no 1882 0.450166302592107 2729 800431
SGTC_2348 9022543 33.42 µM -0.125584898081745 0.441966263224136 no 1883 0.450030258942752 2731 3162678 YDL140C RPO21
SGTC_2282 7944268 200 µM -0.126460167495879 0.441618428707383 no 1884 0.449683838795493 2730 2970414
SGTC_2976 9009005 19.48 µM -0.126518982648477 0.441595057012227 no 1885 0.449660561901852 2691 2993148
SGTC_472 calcifediol 10 µM -0.127673128041428 0.441136469266974 no 1886 0.44920382837066 2706 5283731 A vitamin D metabolite.
SGTC_2932 9016711 44.54 µM -0.12898703000009 0.440614499987781 no 1887 0.448683955826145 2681 7117328
SGTC_145 3737-0113 38.366 µM -0.129437688276307 0.440435492250995 no 1888 0.448505663784098 2747 6849351
SGTC_1066 ketoconazole 628 nM -0.129448013438847 0.440431391095295 no 1889 0.448501579005116 2772 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1425 4048-4433 7.33 µM -0.129553163919444 0.440389625676774 no 1890 0.44845998031256 2672 23734946
SGTC_1377 2944-0135 198 µM -0.129598711981924 0.440371534344824 no 1891 0.448441961171384 2717 1894137
SGTC_2628 lathosterol 100 µM -0.129629223660897 0.440359415415684 no 1892 0.44842989059118 2752 6710616
SGTC_294 k038-0071 157 µM -0.13044197387066 0.440036619883104 no 1893 0.448108379954221 2683 24152826
SGTC_435 c-PAF 6.7 µM -0.131026904021628 0.439804331040304 no 1894 0.447877012271299 2648 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2246 7293507 91.5585 µM -0.131149687071994 0.439755573774012 no 1895 0.447828447986727 2825 887656
SGTC_3297 9117502 71.43 µM -0.131181433230026 0.439742967493046 no 1896 0.447815891580699 2604 7453720
SGTC_2211 7117706 200 µM -0.131605702761051 0.439574497513829 no 1897 0.447648087306747 2646 822771
SGTC_393 acivicin 6.25 µM -0.132149104088437 0.439358738377147 no 1898 0.447433178502969 2666 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_999 SEC7.066 22.7 µM -0.13215047587066 0.439358193729643 no 1899 0.447432635998811 2671 740511 YDR170C SEC7
SGTC_962 1254-0300 21.5 µM -0.13252332859219 0.439210161879031 no 1900 0.44728518610332 2638 7340576
SGTC_2567 aureobasidin a 60 nM -0.134298822014469 0.438505363582837 no 1901 0.44658314235057 2896 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1470 k295-0292 231 µM -0.134638723189573 0.43837045888074 no 1902 0.446448761834136 2741 5045612
SGTC_406 estrone 100 µM -0.134869874706768 0.438278720343986 no 1903 0.446357379194859 2733 5870 A steroid.
SGTC_2991 9074669 71.4286 µM -0.135271913264892 0.438119168710594 no 1904 0.446198445454711 2781 17333109
SGTC_54 0159-0055 9 µM -0.135315729057281 0.438101780733963 no 1905 0.446181124733079 2745 3319099
SGTC_2821 7996764 71.43 µM -0.136555291832851 0.437609918952008 no 1906 0.445691158650967 2779 2987135
SGTC_134 0269-0018 6.916 µM -0.136646913468257 0.437573567061655 no 1907 0.445654946346119 2741 4378915
SGTC_2325 6158266 200 µM -0.136912086866644 0.437468359573234 no 1908 0.445550142434727 2716 3623240
SGTC_2537 larixol 68.93 µM -0.138687796710209 0.436763961361268 no 1909 0.444848430858332 2629 6708759
SGTC_897 1000-0139 31.4 µM -0.138837074446376 0.436704754162242 no 1910 0.444789448255622 2751 6151020
SGTC_352 k048-0007 5.11 µM -0.140019896678717 0.436235668186101 no 1911 0.444322134987478 2643 6811911
SGTC_2224 6650123 117.647 µM -0.140467175271661 0.43605830888835 no 1912 0.444145442831809 2647 2908370
SGTC_2375 9072683 200 µM -0.140798424069396 0.435926967148579 no 1913 0.444014594037066 2644 16798029
SGTC_1733 st037357 54.9 µM -0.140987815341298 0.435851875773308 no 1914 0.443939784069932 2648 1272339 YGL099W LSG1
SGTC_2435 5706476 10.6 µM -0.141214323329344 0.435762071100706 no 1915 0.443850315541982 2732 5725375
SGTC_314 1671-0008 2.74 µM -0.141549981944674 0.435628997064983 no 1916 0.4437177388052 2646 3913060
SGTC_165 k038-0023 64.381 µM -0.141859431613418 0.435506320192833 no 1917 0.443595519525175 2685 46368543
SGTC_2281 7943571 200 µM -0.142196638398707 0.435372646477564 no 1918 0.443462343489554 2731 1244024
SGTC_2301 7769476 200 µM -0.142553182840727 0.435231315063819 no 1919 0.443321537209111 2737 977820
SGTC_719 2810-4230 27.3 µM -0.142740055928519 0.435157243344425 no 1920 0.443247740277924 2645 721079
SGTC_2984 9022109 38.96 µM -0.142886810818676 0.435099075048918 no 1921 0.443189787563543 2627 6459207
SGTC_2897 9048598 12.99 µM -0.1433092915278 0.434931626923124 no 1922 0.443022958999878 2678 6467404
SGTC_1241 0364-0022 50.8 µM -0.144725874167365 0.434370256776355 no 1923 0.44246365479994 2745 4563895
SGTC_716 1683-5115 658 µM -0.145462120337068 0.434078545802613 no 1924 0.442173010598631 2648 723597
SGTC_1816 st051957 91.6 µM -0.146835833568563 0.433534357600199 no 1925 0.441630800062853 2668 674121
SGTC_1302 1159-0335 255 µM -0.147019414319021 0.433461642714618 no 1926 0.441558348210934 2651 649284
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.147090189519017 0.433433609818175 no 1927 0.441530416641614 2741 688662
SGTC_1186 1319-0216 26 µM -0.147533905162024 0.433257868962835 no 1928 0.441355310037871 2838 4565136
SGTC_848 0368-0089 85.6 µM -0.149058777466032 0.432654019101435 no 1929 0.440753626621788 2722 762535
SGTC_2141 5621638 7.665 µM -0.149259781097944 0.432574433306297 no 1930 0.440674324871751 2793 2856238
SGTC_1881 5652484 16 µM -0.149286751332557 0.432563754863699 no 1931 0.440663684514613 2734 2255129
SGTC_2127 5253358 187.912 µM -0.149450681466102 0.432498850350862 no 1932 0.440599011354397 2655 20612
SGTC_2001 4023502 57.655 µM -0.150171940229724 0.432213305545152 no 1933 0.440314481637969 2779 108941 YCR052W RSC6
SGTC_350 k064-0020 19.8 µM -0.152198586275168 0.431411150677569 no 1934 0.439515154481834 2827 2790705
SGTC_2992 9074591 71.4286 µM -0.153049403781847 0.431074477685452 no 1935 0.439179657803658 2685 17741321
SGTC_61 0978-8327 98.565 µM -0.153319298359048 0.430967689423067 no 1936 0.439073241353781 2659 6150059 YHR072W ERG7
SGTC_2663 amphotericin b 100 µM -0.154584213590803 0.430467272126191 no 1937 0.43857455805695 2678 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2800 7887935 81.82 µM -0.154950649952786 0.430322325845776 no 1938 0.438430111462383 2828 2961002
SGTC_3236 9132701 49.47 µM -0.156059219035396 0.429883881393345 no 1939 0.437993171468272 2725 24282524
SGTC_2773 thioridazine 9.09 µM -0.156517362240247 0.429702708749005 no 1940 0.437812617404907 2655 5452 An antipsychotic.
SGTC_2140 5586273 200 µM -0.157743013853144 0.429218097924473 no 1941 0.437329652317518 2671 854421
SGTC_1468 k284-1086 134 µM -0.160016252875965 0.428319564047018 no 1942 0.436434135623264 2712 15996457
SGTC_2470 5664817 21.68 µM -0.160494735324601 0.428130483418885 no 1943 0.436245684236955 2682 2859561
SGTC_1378 2093-0007 380 nM -0.162484235783162 0.427344475257466 no 1944 0.435462270669659 2794 3618014
SGTC_3313 9133968 57.047 µM -0.162673271342732 0.427269806388597 no 1945 0.435387846504992 2667 1494643
SGTC_2890 9046729 58.44 µM -0.165538570903363 0.426138336303873 no 1946 0.434260046698694 2750 903329
SGTC_2583 asiatic acid 100 µM -0.165906981812917 0.425992899455394 no 1947 0.434115076476192 2835 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1121 fusaric acid 630.51 nM -0.166837453401963 0.425625623879307 no 1948 0.433748974061089 2722 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_568 1193-0097 7.48 µM -0.16750908511586 0.425360557606951 no 1949 0.433484749819375 2743 3646150
SGTC_2002 4023503 131 µM -0.16757124853479 0.425336025886542 no 1950 0.433460295831167 2724 4736863 YCR052W RSC6
SGTC_1229 0139-0193 12.2 µM -0.167622268008016 0.42531589214795 no 1951 0.433440225864182 2807 3090752
SGTC_1074 carmofur 3.8 µM -0.168427388748563 0.424998194372871 no 1952 0.433123531384228 2697 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_152 4469-0003 551.229 µM -0.168871323620249 0.424823040072733 no 1953 0.432948927826015 2706 697280
SGTC_315 k915-0449 187 µM -0.169472982960515 0.424585679349365 no 1954 0.432712310719913 2736 20970215 YNL149C PGA2
SGTC_1347 1493-0251 600 nM -0.170142583972717 0.424321547100111 no 1955 0.432449002275401 2833 3986378
SGTC_3163 9099914 49.47 µM -0.171657739583174 0.423724001204649 no 1956 0.431853305740879 2760 16268368
SGTC_2536 dehydroabietamide 32.04 µM -0.172771005497521 0.42328506392892 no 1957 0.431415714269612 2857 3983547
SGTC_2112 5488546 200 µM -0.173102386320325 0.423154425819047 no 1958 0.431285474628318 2710 600757
SGTC_2163 5671233 125 µM -0.173159765662309 0.423131806391363 no 1959 0.431262924097061 2813 701023
SGTC_2412 st077135 33.4 µM -0.173172963663916 0.423126603662015 no 1960 0.431257737210648 3002 13258915
SGTC_1049 3226-0134 66 µM -0.173183847721964 0.423122313112826 no 1961 0.431253459725559 2665 5702385
SGTC_1204 4049-0315 18.3 µM -0.173183903776449 0.423122291015896 no 1962 0.431253437695909 2980 588402
SGTC_139 0099-0334 718.624 µM -0.174282911060062 0.422689103972877 no 1963 0.430821564355639 2701 97690
SGTC_1587 estradiol valerate 56.1 µM -0.176186148851711 0.421939141121356 no 1964 0.430073851092863 2799 13791 A steroid.
SGTC_982 1491-0518 27.5 µM -0.177007577980184 0.421615547692722 no 1965 0.429751218601969 2748 3091256
SGTC_49 0717-0965 32.132 µM -0.17764322533439 0.421365177366394 no 1966 0.429501587749502 3004 5889349 YGL099W LSG1
SGTC_534 k292-0788 63.4 µM -0.177707117477549 0.421340013130266 no 1967 0.429476497642328 2723 4146317
SGTC_291 SEC14.278 35.5 µM -0.178738816001015 0.420933718121878 no 1968 0.429071394589626 2816 1068044
SGTC_1555 citronellol 128 µM -0.182145310356581 0.419592800828077 no 1969 0.42773434545919 2749 8842 A terpine precursor.
SGTC_2763 lisinopril 49.32 µM -0.182200943595518 0.419570909309358 no 1970 0.427712516253411 2723 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2612 dictamnine 15.46 µM -0.183189769761985 0.419181850663616 no 1971 0.427324560544839 2838 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_3230 9131665 49.47 µM -0.184643629984834 0.41860996560626 no 1972 0.426754281253239 2720 15943720
SGTC_2226 7298446 200 µM -0.18610701269228 0.418034508484696 no 1973 0.42618042132824 2798 3283010
SGTC_1272 0839-0021 27 µM -0.18646902618733 0.417892178182342 no 1974 0.426038483186846 2820 5027250
SGTC_2811 7967822 32.47 µM -0.186704114452351 0.417799755938917 no 1975 0.425946314981202 2865 2232244
SGTC_1203 3992-3522 103 µM -0.187146435074206 0.41762587499213 no 1976 0.425772910668112 3089 5322312
SGTC_2490 carminic acid 95.39 µM -0.187419661338416 0.417518474882392 no 1977 0.425665804105379 2693 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1742 st038235 28.8875 µM -0.18752100010991 0.417478642079569 no 1978 0.425626080008363 2865 564103 YBR002C RER2
SGTC_1716 st033144 30.6155 µM -0.187984075746738 0.417296633676918 no 1979 0.425444567175869 2857 674617
SGTC_3265 9137266 49.47 µM -0.189225775517601 0.416808680468216 no 1980 0.424957933322713 2703 17224265
SGTC_2165 5727197 32.143 µM -0.189366071723078 0.416753556034694 no 1981 0.424902957091415 3150 1361712
SGTC_2212 7123476 200 µM -0.189815784455418 0.416576868354691 no 1982 0.424726743278291 2772 1085715
SGTC_1193 1488-0126 41.5 µM -0.190302894100344 0.416385506812488 no 1983 0.42453589296469 2755 1384710
SGTC_2346 9031566 143.75 µM -0.190607446672807 0.416265873075621 no 1984 0.424416577780172 2861 4771086
SGTC_1235 benzylparaben 21.5 µM -0.190644950346462 0.416251141493209 no 1985 0.424401885367948 2829 7180
SGTC_340 k038-0059 454 µM -0.191428679687908 0.415943316643667 no 1986 0.424094876189984 2743 23733424
SGTC_1949 st076024 69.1 µM -0.191772285570289 0.415808375038454 no 1987 0.423960290459225 2689 2921930
SGTC_227 fluconazole 33.516 µM -0.19262998760228 0.41547157988897 no 1988 0.423624379018506 2761 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_3081 9117243 49.47 µM -0.193077818497592 0.415295754114111 no 1989 0.423449012032662 2941 45595589
SGTC_944 3370-0224 231 µM -0.193281068830069 0.415215960284482 no 1990 0.423369425833485 2777 4580514
SGTC_2436 5633522 8.09 µM -0.193877145312441 0.414981967436384 no 1991 0.423136039771179 2849 5724242
SGTC_1340 1486-1359 257 µM -0.194208179950298 0.414852031128494 no 1992 0.423006439069132 2789 4309068
SGTC_2751 anetholtrithion 17.25 µM -0.194420720214865 0.414768610637196 no 1993 0.422923233534888 2891 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1546 5-methoxyflavanone 78.7 µM -0.194515657754772 0.414731349592331 no 1994 0.422886068376168 2833 147795
SGTC_2706 st078239 82.5 µM -0.195360266647142 0.414399891667085 no 1995 0.422555459939411 2744 15434492
SGTC_337 1315-0038 354 µM -0.196812891532557 0.413829966906425 no 1996 0.421986981223382 2767 1626437
SGTC_1028 k015-0029 4.8 µM -0.197636111328656 0.41350706424305 no 1997 0.421664889641901 2740 4588309
SGTC_1674 st016616 23.6 µM -0.198779115594428 0.41305882520136 no 1998 0.421217766661214 2700 625830
SGTC_771 0250-0039 27.3 µM -0.19916965639278 0.412905697182313 no 1999 0.421065017287406 2755 3005115
SGTC_1043 0916-0009 19.3 µM -0.19919641881954 0.412895204327162 no 2000 0.421054550329359 2923 3101130
SGTC_2465 5809242 33.21 µM -0.199738520531667 0.412682673678493 no 2001 0.420842542869113 2734 2731748
SGTC_2434 5670830 169.91 µM -0.200347224595323 0.412444062126195 no 2002 0.42060451563695 2856 1549830
SGTC_607 4491-0986 66.8 µM -0.20039938071142 0.412423618470194 no 2003 0.420584121892892 2882 698981 YDR232W HEM1
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.20043102165508 0.412411216271239 no 2004 0.420571749961521 2778 6708561
SGTC_792 4534-1957 155 µM -0.20446784817021 0.410829635863728 no 2005 0.418993957338766 2819 1717904
SGTC_1486 3970-0793 4.53 µM -0.204647613109474 0.41075923960957 no 2006 0.418923726350817 2877 2844330
SGTC_1395 3486-0190 4.35 µM -0.205296534077855 0.410505144993015 no 2007 0.418670225897985 2877 6748079
SGTC_1662 st014054 52 µM -0.205593716941787 0.410388791173711 no 2008 0.418554142919601 2754 2838777
SGTC_289 k017-0060 526 µM -0.205604399751782 0.41038460875854 no 2009 0.418549970225529 2774 5512909
SGTC_2202 7226349 200 µM -0.206202753287068 0.410150364311533 no 2010 0.418316268625859 2748 844334
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.208169540207361 0.409380629550117 no 2011 0.417548295493904 3119 5282309
SGTC_649 1123-0311 367 µM -0.208723347397135 0.409163950782531 no 2012 0.417332106480331 2872 693629 YIL048W NEO1
SGTC_104 0074-0074 590.992 µM -0.208938622353177 0.409079731280119 no 2013 0.417248076608622 2730 3943124
SGTC_1225 1216-0074 20.6 µM -0.209019368443336 0.409048143014103 no 2014 0.417216559362305 2802 4241466
SGTC_1625 st003711 30.1 µM -0.2093827544662 0.408905991935166 no 2015 0.417074727170268 2974 24207034 YER133W GLC7
SGTC_3258 9138477 49.47 µM -0.209474593620081 0.408870067752456 no 2016 0.417038883392061 2797 4970355
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.209629904467697 0.408809317462038 no 2017 0.416978268902241 2934 23847180
SGTC_1047 2043-3044 82 µM -0.21020369767895 0.408584895585066 no 2018 0.416754346853575 2779 669592
SGTC_3130 9127414 49.47 µM -0.211044261914099 0.408256188417956 no 2019 0.416426366541283 2745 1494646
SGTC_84 0443-0269 128.823 µM -0.211050943294981 0.408253575886279 no 2020 0.416423759761639 2779 6150058
SGTC_625 k213-0058 121 µM -0.211993473704416 0.40788507164991 no 2021 0.416056062922287 2837 3655420
SGTC_2362 9071156 126 µM -0.212542012148252 0.407670645242005 no 2022 0.415842102720713 2956 653133
SGTC_692 k241-0027 77.8 µM -0.21370454832149 0.407216295559238 no 2023 0.415388732117118 2946 3600480
SGTC_742 0kpi-0133 140 µM -0.215479775548881 0.406522731123845 no 2024 0.414696639246508 2951 2728852
SGTC_1027 k015-0025 8.67 µM -0.216427241437901 0.406152685028822 no 2025 0.414327366911346 2764 3598955
SGTC_1961 st076550 68.7 µM -0.217608605928957 0.405691403996566 no 2026 0.413867039306918 2911 1579337
SGTC_1832 st054113 55 µM -0.218499521981092 0.405343619365493 no 2027 0.413519965362572 2861 1251267
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.218743756920699 0.405248291032827 no 2028 0.413424830605395 2863 6857784
SGTC_1956 st077085 54 µM -0.219022127393161 0.405139645976177 no 2029 0.413316405522548 2835 24208685
SGTC_2123 5259487 200 µM -0.219239715541752 0.405054728708588 no 2030 0.413231659710146 2911 2173474
SGTC_862 0452-0056 10.2 µM -0.220365184185566 0.404615567949433 no 2031 0.412793378972643 2787 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_3111 9122088 49.47 µM -0.220406689435928 0.404599374787481 no 2032 0.412777218045565 2845 16876704
SGTC_759 3486-0358 89.3 µM -0.220826697623673 0.404435518918726 no 2033 0.412613687498875 2946 875103
SGTC_1759 st043059 70 µM -0.221023574173413 0.404358718140689 no 2034 0.412537038665223 2806 669426
SGTC_1707 st032323 6.317 µM -0.221355418183747 0.404229275422712 no 2035 0.4124078512636 2807 3132057 YMR211W DML1
SGTC_2093 5331342 194.4 µM -0.222601872567581 0.403743163500414 no 2036 0.411922689459189 2934 33839
SGTC_1271 0832-2808 169 µM -0.224048851430125 0.403179034358288 no 2037 0.411359645675309 2959 3663794
SGTC_1760 st045453 10.4495 µM -0.22469771640719 0.402926128740451 no 2038 0.411107220615391 2900 3323419 YIL048W NEO1
SGTC_3065 9113888 49.47 µM -0.226739771664234 0.402130470145904 no 2039 0.410313049550658 3000 16648368
SGTC_1957 st077035 62.4 µM -0.227171579246617 0.40196227410495 no 2040 0.410145163228259 2862 705593
SGTC_2055 5235184 200 µM -0.227927386358999 0.401667918719991 no 2041 0.409851345894077 2971 2836034
SGTC_2512 diallyl trisulfide 49.23 µM -0.229410838323428 0.401090338307414 no 2042 0.409274806507386 2802 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1358 1509-0022 2.48 µM -0.229548372159973 0.401036800584658 no 2043 0.409221364291557 2864 3258434
SGTC_1921 5740136 50 µM -0.229601156227178 0.401016253852561 no 2044 0.409200854168576 2995 1774243
SGTC_1094 duloxetine 25.4 µM -0.230031732415225 0.400848657946328 no 2045 0.409033555952591 2791 60834 A selective serotonin reuptake inhibitor.
SGTC_1753 st043925 64 µM -0.230760244613153 0.40056513608406 no 2046 0.408750533945135 2923 670181
SGTC_445 e6 berbamine 66 µM -0.232230258827582 0.399993196620425 no 2047 0.408179588475574 2918 6610268 A calcium/calmodulin antagonist.
SGTC_2384 9036245 200 µM -0.232758218112303 0.399787835408865 no 2048 0.407974579484144 2862 6462766
SGTC_931 2812-0076 566 µM -0.233136417031911 0.399640743773321 no 2049 0.407827738606669 2794 3450959
SGTC_1751 st044839 27.194 µM -0.233455959502686 0.399516476292625 no 2050 0.407703681983369 2780 5291326
SGTC_753 1322-0200 289 µM -0.233857502102113 0.39936033405921 no 2051 0.407547803405845 2974 5403907
SGTC_1382 3002-2117 298 µM -0.234899216264904 0.398955332406385 no 2052 0.407143478941505 2951 1497314
SGTC_656 4090-1979 187 µM -0.235848541848086 0.398586344646651 no 2053 0.4067750997498 2942 22330961
SGTC_2414 st077232 92.9 µM -0.236631383639123 0.398282134662767 no 2054 0.406471385466046 2796 729801
SGTC_2471 5466956 24.79 µM -0.240904159649883 0.396622840610186 no 2055 0.404814699069585 2853 724419
SGTC_1338 1486-1223 76 µM -0.241167140441133 0.396520775185588 no 2056 0.404712788733956 2904 3444526
SGTC_2965 9082772 38.63 µM -0.242768598856948 0.395899386766899 no 2057 0.404092331212233 3001 16459634
SGTC_1853 st056710 91.2 µM -0.243023315022246 0.395800577643544 no 2058 0.403993668006375 3011 269167
SGTC_3170 9103054 49.47 µM -0.243881268358165 0.395467810931091 no 2059 0.403661388454031 2895 16432970
SGTC_2310 7668677 200 µM -0.244097899062473 0.395383800350398 no 2060 0.403577499823948 3052 2197143
SGTC_1213 1315-0166 115 µM -0.245136512808789 0.394981087811464 no 2061 0.403175366050687 2951 768401
SGTC_1708 st033234 31.827 µM -0.246747002683505 0.394356857721456 no 2062 0.402552014047189 2970 674664
SGTC_3140 9094243 49.47 µM -0.249002024423989 0.39348326145804 no 2063 0.401679607731623 2808 19291112
SGTC_3026 9090633 49.47 µM -0.251993415933998 0.392325222918788 no 2064 0.400523076473492 2844 25236842
SGTC_1992 st073643 23.3 µM -0.252085343244625 0.39228965071783 no 2065 0.400487549305302 2820 3161292
SGTC_559 1550-0661 158 µM -0.252540917672364 0.392113374881512 no 2066 0.400311495510251 2932 5830875
SGTC_1310 1188-0297 994 nM -0.25299753070284 0.391936719392506 no 2067 0.400135060677252 2895 1588352
SGTC_895 0964-0006 13.7 µM -0.253045478948435 0.391918170357789 no 2068 0.400116534703422 2988 6738897
SGTC_1755 st041960 45.185 µM -0.253519186834153 0.391734927142597 no 2069 0.399933518197544 2974 2257073
SGTC_2796 7949634 45.45 µM -0.253616395551817 0.391697327110431 no 2070 0.399895964435927 2822 2971588
SGTC_875 0709-0210 25.7 µM -0.254366426935664 0.391407251325429 no 2071 0.399606242773557 2860 6251364
SGTC_450 aminopyrene 156 nM -0.254679446887583 0.39128620822901 no 2072 0.399485345956171 2963 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_678 1218-2179 85.9 µM -0.255603171147552 0.390929070545513 no 2073 0.399128634753986 2864 6820081 YOR116C RPO31
SGTC_1692 fluoroquinolonic acid 71 µM -0.255642388825197 0.390913909925467 no 2074 0.399113492069102 2978 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_774 k060-0086 136 µM -0.257987065229927 0.390007815905461 no 2075 0.398208444931157 2907 5911235
SGTC_2275 7947463 200 µM -0.259032332815531 0.38960406720215 no 2076 0.397805146832878 2945 1225414
SGTC_1257 0669-0121 16 µM -0.259375690286769 0.389471466717248 no 2077 0.397672692199516 2960 4307855
SGTC_1722 st034304 3.6505 µM -0.260004992733416 0.389228471169253 no 2078 0.397429961185244 2870 4036148 YLR033W RSC58
SGTC_36 0335-0881 14.2 µM -0.260176512101029 0.389162249087215 no 2079 0.397363810578893 2844 23828853
SGTC_1822 st052468 42 µM -0.260329024524183 0.389103368119048 no 2080 0.397304992941228 2912 2873678
SGTC_517 1365-0151 113 µM -0.261235610270998 0.388753412211196 no 2081 0.396955409127555 3043 768657
SGTC_506 n9-isopropylolomoucine 153 µM -0.262076345520981 0.388428956251302 no 2082 0.396631291557483 3019 6610355
SGTC_3254 9136651 49.47 µM -0.26236998844868 0.388315652106741 no 2083 0.396518104087962 2888 16454030
SGTC_589 1227-0070 34.1 µM -0.262627601939299 0.388216257994392 no 2084 0.396418811689315 2995 2841384
SGTC_2457 5731572 11.68 µM -0.262975408727009 0.388082076532992 no 2085 0.396284766595498 3012 2865357
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.263203415655155 0.387994120280417 no 2086 0.396196899142727 2881 368090
SGTC_540 1187-0821 17.3 µM -0.263347458581771 0.387938557052718 no 2087 0.396141391770506 2858 847520
SGTC_2610 ononetin 44.17 µM -0.265178866332304 0.387232308820719 no 2088 0.395435837255343 2929 259632
SGTC_1177 0983-0204 23.6 µM -0.265792030870976 0.386995936608697 no 2089 0.395199690488319 3022 766818
SGTC_611 3453-1652 23.7 µM -0.267382116151576 0.386383161208246 no 2090 0.394587483792092 2975 1560575
SGTC_136 0097-0015 404.482 µM -0.267415394756237 0.386370339564514 no 2091 0.394574673805011 2882 4861337
SGTC_609 0986-0026 86.3 µM -0.267675868139616 0.386269988173863 no 2092 0.394474413303637 2897 2848610
SGTC_2973 9094665 17.96 µM -0.26849154794062 0.385955784182888 no 2093 0.394160489943214 3097 25237061 YIL048W NEO1
SGTC_1660 st012960 28.1 µM -0.268742955773372 0.385858955682404 no 2094 0.394063746718317 2972 24207266
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.271159442322659 0.384928621165414 no 2095 0.393134202534232 3034 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_641 4092-0595 30 µM -0.271256513405036 0.384891263110064 no 2096 0.393096875117079 2952 786260
SGTC_2290 7904846 200 µM -0.271769650556968 0.384693798721566 no 2097 0.392899571263991 2943 2962154
SGTC_1812 st052057 4.327 µM -0.271938351404158 0.384628886137249 no 2098 0.392834710934676 2853 3645418
SGTC_2938 9059746 27.26 µM -0.271974204170854 0.384615091153486 no 2099 0.39282092702293 3005 6471769
SGTC_344 k064-0035 6.43 µM -0.272707127712761 0.384333117949926 no 2100 0.39253917759714 2884 5088750
SGTC_3036 9090181 49.47 µM -0.273112938049813 0.384177019327335 no 2101 0.392383200775379 2860 25236586
SGTC_1006 4099-6547 255 µM -0.273648069054818 0.383971205059595 no 2102 0.392177544832562 2985 3146833
SGTC_631 k072-0230 41.5 µM -0.27386607437829 0.383887368414225 no 2103 0.392093771939789 2995 5773147
SGTC_2329 6138490 200 µM -0.274176548622643 0.383767981081633 no 2104 0.391974474654622 3127 720019
SGTC_2852 9023854 51.95 µM -0.275661251541325 0.383197217757136 no 2105 0.391404129816227 3044 19798528
SGTC_1852 st056254 31.4 µM -0.276330139622438 0.382940160310463 no 2106 0.391147254352398 2892 442583
SGTC_2883 9059145 45.46 µM -0.277131812008398 0.382632141029449 no 2107 0.390839447817034 2840 16476510
SGTC_853 0419-0306 21 µM -0.27721383020292 0.382600632107745 no 2108 0.390807960331344 2874 762713
SGTC_3094 9117742 49.47 µM -0.278301520725896 0.382182847711224 no 2109 0.390390454421576 2860 17149698
SGTC_1025 k007-0731 70 µM -0.279296516563141 0.381800787638943 no 2110 0.390008639674443 2890 6256118
SGTC_2256 7954252 200 µM -0.281288311174514 0.381036321372085 no 2111 0.389244637433807 2968 2972920
SGTC_3307 9126885 69.2785 µM -0.283189957411469 0.38030688771594 no 2112 0.388515613112384 2908 24824909
SGTC_907 3448-6986 75.5 µM -0.283439465367426 0.380211212946369 no 2113 0.388419989607784 3090 590582
SGTC_1930 st074634 34.3 µM -0.284927387477875 0.379640815941206 no 2114 0.387849886553791 2886 684253 YOR116C RPO31
SGTC_455 paf C-16 10 µM -0.28497954853494 0.379620824670458 no 2115 0.387829905222334 2892 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.287000534775197 0.378846508795614 no 2116 0.387055955380572 2931 2724278 An inhibitor of dopamine biosynthesis.
SGTC_714 4296-0578 26.1 µM -0.287622566538815 0.378608282688691 no 2117 0.38681783445226 2906 1589775
SGTC_394 menadione 8.33 µM -0.289447391869268 0.377909676388383 no 2118 0.386119516390687 3065 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1003 4049-0218 100 µM -0.28983859410404 0.377759962503486 no 2119 0.385969860352829 3071 295161
SGTC_1155 4088-0394 48.2 µM -0.290494149807724 0.37750912118653 no 2120 0.385719112850195 2888 2326248
SGTC_807 1315-0151 48 µM -0.293697670143638 0.376284073545758 no 2121 0.384494467397827 3159 4011080
SGTC_99 0109-0120 622.8 µM -0.294134510666311 0.376117119014391 no 2122 0.384327560473573 3138 759414
SGTC_2713 st079149 53.4 µM -0.295355454019452 0.375650614030024 no 2123 0.383861179338164 3006 3103253
SGTC_2203 7227154 166.4 µM -0.296105813387063 0.375364002569626 no 2124 0.383574637261414 2926 896304
SGTC_2754 granisetron 64.02 µM -0.2977193428008 0.37474792301855 no 2125 0.382958689553942 3069 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_754 3474-0146 171 µM -0.297916771798911 0.374672562374053 no 2126 0.382883343414846 2910 24762078
SGTC_1407 3909-7909 12.3 µM -0.298991490204402 0.374262415504095 no 2127 0.382473269285488 2950 4411780
SGTC_3305 9127027 53.8275 µM -0.299848052713704 0.373935625745252 no 2128 0.382146529975251 2959 41905295
SGTC_555 4296-0685 37 µM -0.300127531157253 0.373829020666318 no 2129 0.382039939912144 2973 2908540 YHR072W ERG7
SGTC_1348 1493-0373 93.8 µM -0.300643125589178 0.373632376142116 no 2130 0.38184332122481 2991 3010129
SGTC_484 loperamide 105 µM -0.300678455739293 0.373618902645294 no 2131 0.38182984940986 2912 3955 An opioid-receptor agonist.
SGTC_2181 6316240 54.2555 µM -0.301851334201051 0.373171701796829 no 2132 0.381382697948778 3016 12779990
SGTC_522 1273-0010 11.6 µM -0.302422463414226 0.372954000649979 no 2133 0.381165016319657 3171 5705015
SGTC_2448 5185112 27.17 µM -0.304350734474786 0.372219288697665 no 2134 0.380430348340008 3075 5718189
SGTC_3077 9117319 49.47 µM -0.304389786223473 0.372204413951736 no 2135 0.38041547413515 2919 17154678
SGTC_2136 5328288 199.296 µM -0.306588914627117 0.371367077933895 no 2136 0.379578146199044 2969 262395
SGTC_883 0850-0245 24.6 µM -0.307001731827283 0.371209962136262 no 2137 0.379421027014346 3145 6823229 YPR165W RHO1
SGTC_2864 9034755 47.6 µM -0.30713032817688 0.371161023505053 no 2138 0.379372087011387 2930 4930451
SGTC_1283 0922-0125 16.4 µM -0.308465891237784 0.37065288489003 no 2139 0.378863925256653 3044 3360884
SGTC_1875 nocodazole 6 µM -0.309852123589942 0.370125706783873 no 2140 0.378336705974905 3039 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_884 0851-0618 334 µM -0.310300742433662 0.369955151188133 no 2141 0.378166133310712 3087 9642473
SGTC_2331 7980721 200 µM -0.310404840273995 0.369915578998963 no 2142 0.378126556899347 3002 2981221
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.311133574353414 0.369638593564712 no 2143 0.377849539148199 2923 15053
SGTC_1139 k015-0024 46.9 µM -0.315497047573175 0.367981495129808 no 2144 0.376192146191898 3096 2766652
SGTC_453 enantio-paf c16 10 µM -0.316400973115204 0.367638520810255 no 2145 0.375849089217473 3071 13871343 A lipid and platelet activating factor
SGTC_3145 9085516 49.47 µM -0.318433995752018 0.366867521823442 no 2146 0.375077877196551 3060 25236195
SGTC_3002 9075603 71.4286 µM -0.321384746046444 0.365749441337427 no 2147 0.373959420692493 2975 20105405
SGTC_1984 st072354 53.1 µM -0.322985677230593 0.365143302333174 no 2148 0.37335304457782 2942 5762938
SGTC_695 3505-6186 243 µM -0.324159733562981 0.3646989991532 no 2149 0.372908552714267 3091 1819379
SGTC_3205 9113483 49.47 µM -0.32471882803151 0.364487482447783 no 2150 0.372696941756034 3149 17018033
SGTC_1882 5615643 20 µM -0.326672695675172 0.363748619317332 no 2151 0.371957726946872 3034 2253075
SGTC_1132 3456-3614 2.5 µM -0.331158909727947 0.362054058980406 no 2152 0.370262227990612 3234 3125502
SGTC_2941 9056145 11.23 µM -0.331492094622597 0.361928313657993 no 2153 0.3701364056718 3010 2119517
SGTC_926 2268-1401 59.4 µM -0.331757512845831 0.361828154414746 no 2154 0.370036184371714 2973 2931578
SGTC_1872 amphotericin b 148 nM -0.331877201773859 0.361782991235419 no 2155 0.369990992999085 3108 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_234 nsc-17383 10.7 µM -0.331918138430344 0.361767544721584 no 2156 0.369975536812595 3141 408974
SGTC_1927 st060202 13.8 µM -0.332780775642011 0.361442100652799 no 2157 0.369649885381143 3032 688887
SGTC_1024 4507-0395 26 µM -0.334320323261263 0.360861530187714 no 2158 0.369068928062058 3154 4201836
SGTC_605 1315-0399 119 µM -0.334678247212432 0.360726601289038 no 2159 0.368933906145103 3141 24020461
SGTC_1973 st070275 50.2 µM -0.335083951084166 0.360573681447228 no 2160 0.368780879463013 3036 17118334
SGTC_1262 0737-0114 49.6 µM -0.335100036936481 0.360567618750269 no 2161 0.368774812499154 3160 765919
SGTC_2902 5787006 60.46 µM -0.335323776504906 0.360483295787083 no 2162 0.368690429943958 2982 591003
SGTC_1491 4138-0063 26.5 µM -0.33541462222996 0.360449059788821 no 2163 0.368656169619775 3082 23883227
SGTC_495 decylubiquinone 155 µM -0.33748448136125 0.359669319076158 no 2164 0.367875854381661 3056 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2386 9075165 157.42 µM -0.338104087865857 0.359436019277894 no 2165 0.367642375047196 2983 16452277
SGTC_2779 methotrexate 400 µM -0.339258260430857 0.359001579610993 no 2166 0.367207591671095 3091 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_570 0987-0065 62.6 µM -0.339944073012338 0.358743520644256 no 2167 0.366949322753383 2954 3104428
SGTC_1799 st045822 46.1415 µM -0.339954175345172 0.358739719799255 no 2168 0.366945518783855 3146 3674992
SGTC_2835 9006588 71.43 µM -0.34025920303009 0.358624964484537 no 2169 0.366830668692327 3205 2345538
SGTC_2090 5301565 104.445 µM -0.340577515774699 0.35850522476909 no 2170 0.366710829173282 3010 2056344
SGTC_1216 1165-0504 9.65 µM -0.342338480792841 0.357843054111774 no 2171 0.36604808979793 3148 6304004
SGTC_924 2046-0044 21.3 µM -0.342622616846266 0.357736251247771 no 2172 0.365941192538016 2974 3623589
SGTC_2491 paeonol 100 µM -0.343171194171037 0.357530080034897 no 2173 0.365734837007684 2953 11092 Increases levels of cortical cytochrome oxidase.
SGTC_751 0833-0568 350 µM -0.34385078496434 0.357274727826689 no 2174 0.365479252683197 3109 6954252
SGTC_963 1269-2853 151 µM -0.344446970961849 0.357050767089445 no 2175 0.365255084873151 3011 3668223
SGTC_2813 7971799 71.43 µM -0.345131270399958 0.356793766732991 no 2176 0.364997842872765 3115 2234054
SGTC_2371 9071574 200 µM -0.345320098727026 0.356722860461423 no 2177 0.364926869174692 3124 45596039
SGTC_1485 3909-9022 254 µM -0.345716011316418 0.356574208769217 no 2178 0.364778075062814 3074 714516
SGTC_327 1273-0057 3.96 µM -0.346321535257988 0.356346897296673 no 2179 0.364550543023645 3051 3108138
SGTC_1636 st007707 68.9 µM -0.346567447876482 0.356254597164931 no 2180 0.36445815236883 3225 403051
SGTC_463 ikarugamyin 104 µM -0.347893073464476 0.355757185859956 no 2181 0.363960243660148 3071 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1790 st045711 43.5 µM -0.348009699215683 0.35571343639635 no 2182 0.36391644967498 3179 585119
SGTC_2176 5809774 33.9695 µM -0.349613374549301 0.355112047505002 no 2183 0.363314436105318 3133 2870539
SGTC_2963 9082507 9 µM -0.349688966999199 0.355083708725884 no 2184 0.363286067306584 3181 16459611
SGTC_969 1313-0238 134 µM -0.351509643584949 0.354401399554037 no 2185 0.362603019487365 3010 5212874
SGTC_1934 st074720 32.6 µM -0.352356705880712 0.354084117064796 no 2186 0.362285383128928 2987 17250992
SGTC_2898 9056270 58.44 µM -0.353791303068665 0.353546993878524 no 2187 0.361747645830005 3073 19154699
SGTC_1968 st069590 43.6 µM -0.355052054783755 0.35307520023588 no 2188 0.361275297138057 3150 6384066
SGTC_482 fipronil 114 µM -0.357562821228685 0.35213630400299 no 2189 0.36033525276047 3087 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2989 9073649 71.4286 µM -0.358839486414002 0.35165924255856 no 2190 0.359857585679037 3109 21367202
SGTC_616 4092-0450 108 µM -0.359283502437731 0.351493378315862 no 2191 0.359691507351033 3084 787165
SGTC_2098 5376439 882.5 nM -0.360454554557688 0.35105606205428 no 2192 0.359253617923586 3135 2844116
SGTC_1801 st050089 28.441 µM -0.361496197222295 0.350667237978271 no 2193 0.358864273621403 3045 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_3150 9097574 49.47 µM -0.362435177904853 0.35031686953813 no 2194 0.35851342783848 3216 17217476
SGTC_320 4092-0846 5.34 µM -0.363146600934577 0.350051496048256 no 2195 0.358247687392572 3130 1359356
SGTC_1721 st082152 9.2685 µM -0.364828422354716 0.349424437949767 no 2196 0.357619743654126 2999 5296051
SGTC_3041 9091929 49.47 µM -0.365012027141258 0.349356006725768 no 2197 0.357551214200781 3234 25236887
SGTC_390 dec-rvkr-cmk 16.7 µM -0.366308342287902 0.348872997365385 no 2198 0.357067502661 3121 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_271 rotenone 740 µM -0.367436066260361 0.348453004452424 no 2199 0.356646886573844 3164 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_89 0302-0250 142.109 µM -0.367848500748789 0.348299449778174 no 2200 0.356493101129323 3069 4203518 YLR208W SEC13
SGTC_1982 st072467 71.9 µM -0.367956216675287 0.348259349844394 no 2201 0.35645294067271 2994 3163533
SGTC_684 1140-0066 328 µM -0.368108120383834 0.348202802792074 no 2202 0.356396308091965 3119 6813534
SGTC_200 k038-0079 37.545 µM -0.36811210370307 0.34820132002337 no 2203 0.356394823077682 3039 3436683
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.3688967210962 0.347909295778234 no 2204 0.356102353721695 3025 3256 An antibiotic and ribosome inhibitor.
SGTC_2478 5763493 32.33 µM -0.370725053928851 0.34722916460016 no 2205 0.355421163829467 3041 1365576 YLR208W SEC13
SGTC_718 1130-0073 349 µM -0.370919909912354 0.347156708051347 no 2206 0.355348592673043 3219 6740020
SGTC_3136 9095672 49.47 µM -0.371060886758144 0.347104289763503 no 2207 0.355296091254406 3054 17217380
SGTC_1518 st038567 90.8 µM -0.372315088160931 0.346638079009692 no 2208 0.354829133054075 3127 77966
SGTC_3234 9132280 49.47 µM -0.376670076037171 0.345021052938389 no 2209 0.353209401761376 3136 17612295
SGTC_3333 9141820 12.094 µM -0.377123039254173 0.344853027472242 no 2210 0.353041085136858 3058 1939433
SGTC_1691 st019933 84.6 µM -0.377521058971219 0.344705408398009 no 2211 0.352893208699678 3157 6176082
SGTC_3283 9109332 35.8195 µM -0.380760270267265 0.343504918203521 no 2212 0.351690571100919 3086 17027281
SGTC_1607 st000305 50.6 µM -0.380916466385582 0.343447069823925 no 2213 0.351632616792111 3210 5457690
SGTC_1230 0170-0365 3.77 µM -0.382494599322297 0.342862802594148 no 2214 0.351047267023928 3201 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2352 9027995 87.8 µM -0.382921928664466 0.34270465835122 no 2215 0.350888825805686 3122 2997347
SGTC_3048 9093155 49.47 µM -0.383179055868938 0.342609515078433 no 2216 0.350793503051481 3197 25236002
SGTC_2677 mitomycin C 100 µM -0.385722941943289 0.341668754691656 no 2217 0.349850935025249 3097 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2495 cafestol 54.53 µM -0.38598738793412 0.341571015591436 no 2218 0.349753004686467 3248 16667697 An anti-infammatory.
SGTC_1554 st069299 38.7 µM -0.388156515836659 0.34076970847252 no 2219 0.348950105283433 3164 24207999
SGTC_901 1112-0062 60.1 µM -0.388180731942472 0.34076076673978 no 2220 0.348941145536633 3092 1908457
SGTC_583 1488-1091 88.9 µM -0.389823244089064 0.340154482570501 no 2221 0.348333627269831 3182 4303273
SGTC_2810 7959871 45.46 µM -0.391368543445417 0.339584458628442 no 2222 0.347762420230285 3176 2974535
SGTC_633 0437-0093 97.7 µM -0.391519836362735 0.339528669983177 no 2223 0.347706514605543 3108 2831118
SGTC_952 1185-0122 232 µM -0.392726673504075 0.339083779695337 no 2224 0.347260683864573 3063 678600
SGTC_1863 st057641 20.1 µM -0.393051917892696 0.338963919450118 no 2225 0.347140567938332 3168 3921635
SGTC_841 0251-0215 91.2 µM -0.393206605410664 0.33890691916232 no 2226 0.347083445715826 3156 3888614
SGTC_933 2914-0560 114 µM -0.394306544793171 0.338501712587612 no 2227 0.346677365931084 3258 463887
SGTC_1117 retinoic acid 1.10837 µM -0.394992131101819 0.338249244028822 no 2228 0.346424347636306 3246 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2974 9094440 9.66 µM -0.395866753813312 0.337927267983656 no 2229 0.346101664182204 3256 25236134
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.396894361170988 0.337549124957922 no 2230 0.345722681283543 3141 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_3115 9123671 49.47 µM -0.397491692156916 0.337329392069767 no 2231 0.345502455858924 3231 3286988
SGTC_2364 9055074 200 µM -0.397828803115392 0.337205407640517 no 2232 0.345378192055056 3190 6470630
SGTC_2513 baicalein 25.65 µM -0.399089284416353 0.3367419779657 no 2233 0.344913708795348 3140 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_560 2332-1943 155 µM -0.399957891214745 0.336422769379774 no 2234 0.344593765928526 3127 21177716
SGTC_2201 6605497 169.863 µM -0.40052817739992 0.336213256183377 no 2235 0.344383766979463 3130 670741
SGTC_1434 4073-0095 163 µM -0.401099023491537 0.336003588222938 no 2236 0.344173609885878 3208 24133745
SGTC_806 3966-4455 5.86 µM -0.402172310808776 0.335609515133609 no 2237 0.343778609279991 3118 714982
SGTC_2287 7945887 168.79 µM -0.402841829091959 0.335363783240764 no 2238 0.343532293602791 3191 1245853
SGTC_2507 purpurin 79.67 µM -0.403149309339415 0.33525095300008 no 2239 0.343419193917747 3087 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_101 0490-5701 117.494 µM -0.404422300767705 0.334783985511113 no 2240 0.342951101950809 3195 4661669
SGTC_354 2783-3500 4.88 µM -0.404793604602963 0.33464782935335 no 2241 0.342814615089656 3135 6740761
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.406588220270424 0.333990055164626 no 2242 0.3421552252239 3136 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2232 chlorophetanol 41.5365 µM -0.406917345178802 0.333869477413976 no 2243 0.342034348055919 3219 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1104 tacrolimus 29.8 µM -0.407420056003045 0.333685338073452 no 2244 0.341849749521037 3185 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_3209 9113616 49.47 µM -0.4078159980115 0.333540335571637 no 2245 0.341704383769533 3326 16649353
SGTC_1190 1486-1332 13 µM -0.409094255936947 0.333072379759339 no 2246 0.341235245731704 3175 4150046
SGTC_2603 homopterocarpin 100 µM -0.409796781696296 0.332815303581438 no 2247 0.340977513624349 3213 101795 A weak amylase inhibitor.
SGTC_1739 st037196 92.5 µM -0.412508967675324 0.331823567931504 no 2248 0.339983204556302 3284 612214
SGTC_954 1189-0853 2.85 µM -0.413446714083687 0.331480945909465 no 2249 0.339639677578432 3177 2828194
SGTC_2839 9003951 25.97 µM -0.414358082685921 0.331148096547461 no 2250 0.339305941242243 3241 2990634
SGTC_821 1114-0266 29.2 µM -0.414581289870008 0.331066597309398 no 2251 0.339224223648742 3211 3123235
SGTC_642 0335-0876 158 µM -0.414931437779189 0.330938764558659 no 2252 0.33909604747118 3165 6812350
SGTC_1118 chelidonine 707.474 nM -0.418732268148858 0.329552420000182 no 2253 0.337705905146409 3240 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_798 1287-0182 476 µM -0.420069852283445 0.329065094574385 no 2254 0.337217212790798 3302 1649755
SGTC_402 epigallocatechin gallate 10 µM -0.421521695183398 0.328536469578997 no 2255 0.336687086190329 3146 65064 An antioxidant.
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.421541766630009 0.328529163842295 no 2256 0.33667975956363 3061 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2671 danthron 100 µM -0.421549154927729 0.328526474617768 no 2257 0.336677062648599 3200 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2655 perillic acid 100 µM -0.421937707265425 0.32838506017828 no 2258 0.336535243083843 3165 5702197 An apoptosis inducer.
SGTC_111 0083-0039 52.457 µM -0.422036559441636 0.32834908664307 no 2259 0.336499166267201 3081 759313
SGTC_347 4534-1311 26.2 µM -0.4228467762866 0.328054298668148 no 2260 0.336203528517987 3161 2862016
SGTC_71 0417-1750 47.813 µM -0.423119384993669 0.327955137225547 no 2261 0.336104079853067 3303 6811472
SGTC_653 0203-0016 55.2 µM -0.425812052852153 0.326976331446146 no 2262 0.335122401810284 3194 295302
SGTC_116 0155-0182 31.788 µM -0.426997048137662 0.326545952802902 no 2263 0.334690738861026 3157 771486
SGTC_2588 indole-3-carbinol 100 µM -0.428998571278192 0.325819543535289 no 2264 0.333962132213774 3280 3712 Induces cell cycle arrest.
SGTC_2845 9003024 42.97 µM -0.429533751025401 0.325625423534811 no 2265 0.333767418683078 3359 2990173
SGTC_1162 k048-0130 20.1 µM -0.429912170334537 0.325488192094935 no 2266 0.333629766042496 3153 6797406
SGTC_1690 st023502 41.2 µM -0.430731910748324 0.325190999402715 no 2267 0.333331656611776 3252 24207482
SGTC_2486 5283202 22.39 µM -0.430748967857547 0.325184816615013 no 2268 0.333325454685807 3174 1377751
SGTC_1724 st037281 8.293 µM -0.432082305312922 0.324701663218118 no 2269 0.332840797346801 3130 574124 YDL195W SEC31
SGTC_1150 3909-7983 10.9 µM -0.432349128475613 0.324605011503915 no 2270 0.332743842790366 3177 23965914
SGTC_2183 6420625 130.508 µM -0.432915160419563 0.324400016097619 no 2271 0.332538202869077 3248 2897619
SGTC_563 tetrahydrosecaminediol 614 µM -0.433702534360784 0.324114947461191 no 2272 0.332252233000556 3297 334274 A psychoactive constituent of the cannabis plant.
SGTC_386 1509-0011 3.07 µM -0.433886946702053 0.324048195890569 no 2273 0.332185269562975 3173 3107280
SGTC_2367 9070478 135.38 µM -0.433922900376657 0.324035182429929 no 2274 0.332172214761194 3173 572802
SGTC_5 0352-0601 109.883 µM -0.435735278289214 0.323379469733085 no 2275 0.331514403394667 3213 762456
SGTC_1010 4112-3296 15.2 µM -0.435890195341723 0.323323446628921 no 2276 0.331458199563558 3321 704384
SGTC_2640 pentamidine 10.38 µM -0.435985608404138 0.323288944119025 no 2277 0.331423585639483 3259 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3114 9122766 49.47 µM -0.436124005391244 0.323238900806543 no 2278 0.331373380578284 3215 17176985
SGTC_465 cgp-37157 41 µM -0.436961976879908 0.322935964939494 no 2279 0.331069461757641 3208 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2812 7970281 58.44 µM -0.439392792006299 0.322057863641805 no 2280 0.330188474219426 3317 2233435
SGTC_3064 1327-0027 10 µM -0.439584051593839 0.32198881558225 no 2281 0.330119196868141 3185 16000455 YPR107C YTH1
SGTC_1184 1269-1718 139 µM -0.439754292145105 0.321927360931697 no 2282 0.330057537854858 3310 5403821
SGTC_3353 9151644 39.2805 µM -0.439810294858733 0.321907145736425 no 2283 0.330037255376443 3292 4909158
SGTC_1209 2323-2347 50.3 µM -0.440585039228367 0.321627541804961 no 2284 0.329756717826777 3280 5412760
SGTC_1456 k015-0012 13 µM -0.440665161713024 0.321598631496358 no 2285 0.329727710665241 3355 2989616
SGTC_1697 st025554 27.742 µM -0.440924375851516 0.321505107591369 no 2286 0.329633873034132 3149 1269519
SGTC_2171 5739187 198.077 µM -0.441511823850267 0.32129319949218 no 2287 0.329421251770342 3106 2262761
SGTC_871 0574-0004 149 µM -0.441841453681434 0.321174318725397 no 2288 0.329301969507913 3150 9551173
SGTC_2647 atorvastatin 60.16 µM -0.442689936331102 0.320868398361652 no 2289 0.328995011300412 3229 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1895 st058434 18.3 µM -0.44508508736372 0.320005483376667 no 2290 0.328129132640849 3346 5393175
SGTC_1447 4239-0816 81.9 µM -0.446698033357871 0.319424925790986 no 2291 0.327546550998537 3202 1341554
SGTC_120 rhodamine 6G 52.259 µM -0.44745091047928 0.319154089434703 no 2292 0.327274762092218 3151 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_882 0843-0131 351 µM -0.448764510663857 0.318681772410272 no 2293 0.326800771237147 3322 5425421
SGTC_1175 0741-0056 27.6 µM -0.449996892882678 0.31823892568641 no 2294 0.326356340488273 3356 765927
SGTC_1402 3909-7673 35.9 µM -0.453935170806878 0.316825480113888 no 2295 0.324937744192959 3221 5328014
SGTC_1198 1612-1005 86.7 µM -0.454078521819136 0.316774081755569 no 2296 0.324886155804794 3374 6998509
SGTC_131 0141-0277 33.849 µM -0.454441530943885 0.316643941025843 no 2297 0.32475553306133 3322 1547771
SGTC_2413 inermin 26.06 µM -0.454455082876654 0.31663908302414 no 2298 0.3247506570428 3412 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_782 0083-0095 30.5 µM -0.454777067992398 0.31652366936486 no 2299 0.324634814845666 3183 3591729 An indicator and reagent.
SGTC_2745 rifampicin 24.3 µM -0.454824145732266 0.316506796124205 no 2300 0.324617878872562 3227 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2644 guaiazulene 100 µM -0.455435336333847 0.316287772573524 no 2301 0.324398039143938 3288 3515 A coloring agent.
SGTC_1458 k015-0034 6.33 µM -0.455994261793522 0.316087534928572 no 2302 0.324197052273271 3248 3598957
SGTC_176 1486-1328 72.834 µM -0.458010469855627 0.315365667544213 no 2303 0.323472459662399 3266 22310231
SGTC_68 0986-0284 82.829 µM -0.459927706071088 0.314679888328599 no 2304 0.32278405627093 3320 423278 YIL048W NEO1
SGTC_40 0327-0103 19.753 µM -0.460989480397296 0.314300375256947 no 2305 0.322403076205482 3190 409036
SGTC_2450 5739737 12.93 µM -0.461982260206873 0.313945700578271 no 2306 0.322047021022554 3298 2262825
SGTC_1133 3473-0247 50 µM -0.462878885370172 0.313625525182834 no 2307 0.321725591495335 3224 711311
SGTC_2317 5986382 200 µM -0.463368621528165 0.313450704807662 no 2308 0.321550083175816 3260 877883
SGTC_1291 0993-0025 5.79 µM -0.46441217925949 0.313078327385229 no 2309 0.321176232920986 3348 4353356
SGTC_1211 1056-0033 32.3 µM -0.464842764800702 0.312924735116238 no 2310 0.321022030197503 3334 6741922
SGTC_2549 cedrol 20.94 µM -0.467179478779887 0.31209178287546 no 2311 0.320185737185168 3319 6708665 A sedative which affects the nervous system.
SGTC_2912 7964298 10.93 µM -0.468097012179838 0.311764978280045 no 2312 0.319857607911571 3310 2975850
SGTC_2944 9067346 25.62 µM -0.470471000446482 0.310920105609356 no 2313 0.319009274122858 3344 6473075
SGTC_1985 st071382 65.5 µM -0.471027890910234 0.310722059293976 no 2314 0.31881040886423 3276 6123237
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.471030008179604 0.310721306436499 no 2315 0.318809652888074 3267 688788
SGTC_70 0141-0289 43.283 µM -0.471249219798436 0.310643363579052 no 2316 0.318731386929146 3252 352408
SGTC_2076 5212012 200 µM -0.473336963468512 0.309901471988924 no 2317 0.317986397431184 3261 604802
SGTC_1309 pyrazolanthrone 13.4 µM -0.473392696350573 0.309881677578874 no 2318 0.317966519807709 3327 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1064 honokiol 6.76 µM -0.474488778794701 0.309492498716976 no 2319 0.317575698983817 3288 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_942 3253-1115 227 µM -0.475011150343983 0.309307098759417 no 2320 0.317389512865695 3392 46497897
SGTC_1424 4048-1941 275 µM -0.476967082579572 0.30861333129369 no 2321 0.316692780936882 3358 X1424
SGTC_355 1311-2252 105 µM -0.477650595202375 0.308371050785988 no 2322 0.31644945673657 3243 5338538
SGTC_3086 9117350 49.47 µM -0.478443962941771 0.308089935244909 no 2323 0.316167124734122 3278 2679265
SGTC_1231 0242-0792 125 µM -0.478563819833852 0.308047475900394 no 2324 0.316124481145194 3218 3707635
SGTC_2143 5623677 140.463 µM -0.47867369441587 0.308008555049619 no 2325 0.316085391286657 3312 5375313
SGTC_1849 st056239 19.2 µM -0.47893270783118 0.307916813325952 no 2326 0.315993250742168 3211 5393181
SGTC_566 0958-0068 16.5 µM -0.480437273670951 0.307384138456607 no 2327 0.315458247821534 3352 6815365
SGTC_2744 captopril 92.04 µM -0.480810466771813 0.307252076374558 no 2328 0.315325605287954 3292 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2106 5357045 167.29 µM -0.482035571829377 0.306818723412813 no 2329 0.314890338461331 3296 668842
SGTC_2690 usnic acid 100 µM -0.483548033466484 0.306284096825534 no 2330 0.314353331393009 3468 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.484031113080965 0.306113424114662 no 2331 0.31418189423787 3320 97141
SGTC_1071 trifluoperazine 6.31 µM -0.487096999974233 0.305031224066227 no 2332 0.313094796162167 3377 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1507 4075-3230 155 µM -0.488675816732468 0.304474595203336 no 2333 0.312535613731239 3311 659771
SGTC_3095 9117207 49.47 µM -0.490137230348759 0.303959761326918 no 2334 0.312018397254956 3320 17015229
SGTC_170 4197-0004 226 µM -0.490801472884645 0.303725887121326 no 2335 0.311783434101495 3374 218692
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.491292716919358 0.303552975906168 no 2336 0.311609715135677 3170 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_928 2764-0428 58.7 µM -0.491751328452077 0.303391590575033 no 2337 0.311447573859798 3337 662578
SGTC_2276 7947513 42.08 µM -0.492184197202294 0.303239299306124 no 2338 0.311294567439106 3298 2105100
SGTC_2857 9024691 58.44 µM -0.492678717663054 0.303065359658159 no 2339 0.311119808835131 3335 16478292
SGTC_2522 biochanin a 4.94 µM -0.492968919471964 0.302963306609196 no 2340 0.311017274227213 3377 5280373 A possible chelator.
SGTC_167 3672-0051 66.205 µM -0.493533904888655 0.302764666644486 no 2341 0.31081769467824 3260 3237971
SGTC_2822 7994718 71.43 µM -0.493721043550544 0.302698884504062 no 2342 0.31075160072435 3293 1018011
SGTC_1008 4106-0037 6 µM -0.49384471567349 0.302655415350033 no 2343 0.310707925342716 3319 2905394
SGTC_666 0272-0154 136 µM -0.49394244734457 0.302621065908437 no 2344 0.310673412838316 3303 6870312
SGTC_2350 9023895 38.85 µM -0.495040913608548 0.30223511166928 no 2345 0.310285620262545 3377 2997209
SGTC_2019 4016004 108 µM -0.495913224319533 0.301928776307126 no 2346 0.309977817757378 3307 45595336
SGTC_533 1222-0222 6.71 µM -0.498349887255443 0.301073816600799 no 2347 0.309118725667928 3416 3982874
SGTC_2359 9039622 200 µM -0.498469472096389 0.301031885587002 no 2348 0.309076590554237 3294 6463596
SGTC_3288 9119690 36.221 µM -0.498498686408467 0.3010216423332 no 2349 0.309066297420896 3287 17595618 YKL019W RAM2
SGTC_769 0302-0231 76 µM -0.498773232922997 0.300925387273877 no 2350 0.308969573257356 3368 571869 YER009W NTF2
SGTC_2553 4-methylesculetin 85.09 µM -0.500086262123534 0.300465235815843 no 2351 0.308507169478249 3331 5319502
SGTC_1606 st000094 49.2 µM -0.500401181398206 0.300354919539325 no 2352 0.308396310834699 3405 1242210
SGTC_2095 5432005 200 µM -0.500544216538307 0.300304820349976 no 2353 0.30834596502763 3258 783734
SGTC_1897 st060201 15 µM -0.500988582474209 0.300149201764188 no 2354 0.308189579174618 3306 611878
SGTC_1907 st060210 83.7 µM -0.502058235358291 0.299774755020362 no 2355 0.307813278671846 3407 688793
SGTC_229 benomyl 22.8748 µM -0.502243943988801 0.299709766710375 no 2356 0.307747967536343 3351 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2270 7924575 90.91 µM -0.503046059478137 0.299429141568618 no 2357 0.307465944700157 3393 1262135
SGTC_1999 st074831 12.5 µM -0.504451164338013 0.298937844177826 no 2358 0.306972185827617 3280 17112523
SGTC_2515 chrysin 20.77 µM -0.50505286591745 0.298727570190088 no 2359 0.306760852684784 3338 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_3034 9090421 49.47 µM -0.506227691886297 0.298317202880853 no 2360 0.30634840858449 3333 17173761
SGTC_957 1187-1561 14.1 µM -0.506565202291139 0.298199357796553 no 2361 0.306229964721125 3380 1538454
SGTC_1793 st048256 72.231 µM -0.506601462369981 0.298186698494022 no 2362 0.306217241032398 3330 672022
SGTC_16 erodoxin 22.806 µM -0.506905036054423 0.298080722914951 no 2363 0.306110725970702 3409 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1866 st057638 64 µM -0.508833741638821 0.29740782570672 no 2364 0.305434383156604 3312 688802
SGTC_1754 st042065 16.137 µM -0.50917383818886 0.297289242981986 no 2365 0.305315189613789 3365 1126236 YIL048W NEO1
SGTC_785 1270-0111 65.3 µM -0.509530728896895 0.297164827812669 no 2366 0.305190132419941 3317 6741994
SGTC_3278 9139605 49.47 µM -0.510050245018494 0.296983762581724 no 2367 0.305008130701112 3437 7958859
SGTC_3309 9129340 25.759 µM -0.510692888286846 0.296759854107946 no 2368 0.30478306065637 3317 17158987
SGTC_313 3474-0040 5.03 µM -0.511203965869642 0.296581840676158 no 2369 0.304604120985409 3299 1043375 YIL048W NEO1
SGTC_2075 5212009 200 µM -0.513067782972526 0.295933069417077 no 2370 0.303951953340648 3381 780898
SGTC_551 k048-0028 34.9 µM -0.51343001673654 0.295807056075892 no 2371 0.303825276534862 3418 6836383
SGTC_1594 piperine 70.1 µM -0.513799642768088 0.295678496538827 no 2372 0.303696038861944 3318 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_269 exalamide 29 µM -0.513914921376621 0.295638406768752 no 2373 0.303655737361726 3308 3316 A derivative of salicylamide.
SGTC_951 1171-0579 82.7 µM -0.514218901969575 0.295532705191406 no 2374 0.303549476935781 3371 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1476 4112-3294 3.34 µM -0.515337440209502 0.295143911456046 no 2375 0.303158620189643 3423 704369
SGTC_3001 9076041 71.4286 µM -0.515764271753984 0.294995610796749 no 2376 0.303009529534509 3344 16004211
SGTC_2085 5307070 144.047 µM -0.517204452187623 0.294495480238803 no 2377 0.30250672221143 3274 2840351
SGTC_990 3985-0011 41.3 µM -0.517368347930756 0.294438589076594 no 2378 0.302449525330414 3309 5399565 YGL099W LSG1
SGTC_2614 arthonioic acid 13.39 µM -0.517422822327785 0.294419681156368 no 2379 0.302430515748127 3364 6710684
SGTC_1990 st072050 59.8 µM -0.517995656548105 0.294220885849837 no 2380 0.302230649899519 3290 17233948
SGTC_3156 9099931 49.47 µM -0.519634985053692 0.293652319317975 no 2381 0.301659004592985 3269 18111053
SGTC_361 000s-0510 1.45 µM -0.519836109670314 0.293582598526211 no 2382 0.301588904533325 3340 660
SGTC_1255 0566-0045 221 µM -0.520796058714963 0.293249933327487 no 2383 0.301254424485637 3438 2788469
SGTC_428 3448-4153 16.5 µM -0.521716697925416 0.292931054988645 no 2384 0.300933798414127 3226 3834874
SGTC_2288 7946289 167.31 µM -0.521980115015692 0.292839845819004 no 2385 0.300842087879363 3468 1246052
SGTC_2264 7948757 110.76 µM -0.522675060872718 0.292599281464927 no 2386 0.300600198058554 3249 2971411
SGTC_2876 9059903 25.97 µM -0.524047551954675 0.292124446137533 no 2387 0.300122733202665 3404 6916095
SGTC_3159 9100096 49.47 µM -0.52472231498216 0.291891132600486 no 2388 0.299888121168212 3349 25236875
SGTC_2602 kawain 100 µM -0.525293526704451 0.291693691970123 no 2389 0.299689578360768 3409 5369129
SGTC_2425 5628681 7.85 µM -0.527013561810782 0.291099534171451 no 2390 0.299092085352653 3384 5714958
SGTC_2895 9054447 58.44 µM -0.527987165119057 0.290763469663673 no 2391 0.298754122136635 3360 2697450
SGTC_2659 sanguinarine 24.21 µM -0.528343694854334 0.290640449547692 no 2392 0.298630404759504 3313 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1475 4092-1048 11.7 µM -0.528619363861023 0.290545347013987 no 2393 0.298534762382496 3412 2881759
SGTC_1803 st050068 52.4 µM -0.528692080233221 0.290520263156531 no 2394 0.298509536019665 3476 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1345 1488-0192 31.4 µM -0.529560074375408 0.290220922740837 no 2395 0.298208491184601 3435 658348
SGTC_220 paclitaxel 373.376 µM -0.530008209763514 0.290066433305791 no 2396 0.298053119341058 3396 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2861 9024595 19.48 µM -0.535536024762981 0.288163961636944 no 2397 0.296139626833434 3327 16482810
SGTC_1913 st060213 96.1 µM -0.535572168494662 0.288151541681869 no 2398 0.296127133990592 3476 688959
SGTC_640 3381-0960 37.1 µM -0.53756967045777 0.28746553946354 no 2399 0.295437086906541 3418 1745025
SGTC_2666 tannic acid 100 µM -0.541753371370357 0.286031239073297 no 2400 0.293994208644258 3462 16134267 A thiamine antagonist.
SGTC_1958 st076513 41.9 µM -0.541807522329156 0.286012696786493 no 2401 0.293975554392059 3328 732122 YGL099W LSG1
SGTC_2146 5545642 200 µM -0.542404530176706 0.285808308166885 no 2402 0.293769929778383 3444 825326
SGTC_1432 4049-0298 68.4 µM -0.543275376271263 0.285510294274818 no 2403 0.293470107738385 3432 741646
SGTC_83 0170-0301 39.027 µM -0.543350816148679 0.28548448481538 no 2404 0.293444141350714 3395 3089716
SGTC_603 3794-0023 45.9 µM -0.543479074024797 0.285440607833934 no 2405 0.293399997463636 3427 3802260
SGTC_3267 9137951 49.47 µM -0.544375237099834 0.285134120346303 no 2406 0.29309164130696 3357 16643986
SGTC_194 1486-1323 56.904 µM -0.544611407490667 0.285053376271009 no 2407 0.293010403680839 3394 5178754
SGTC_193 1273-0060 1.558 µM -0.54519911177075 0.284852493932827 no 2408 0.292808291179023 3385 2847393 YHR072W ERG7
SGTC_2294 7971431 200 µM -0.549520610266209 0.28337744697427 no 2409 0.291324112221022 3398 5741572
SGTC_520 3584-0023 682 µM -0.551340862098417 0.282757242684047 no 2410 0.290700016027518 3367 1340790
SGTC_1287 0971-0001 34.6 µM -0.551611727598777 0.282665007958536 no 2411 0.290607199863875 3454 4665869
SGTC_1850 st056238 17 µM -0.551794370930081 0.282602822680538 no 2412 0.290544622189174 3441 5393177
SGTC_2030 5175110 200 µM -0.555554783465578 0.281323964225207 no 2413 0.289257624725642 3486 2831986
SGTC_919 tnp00227 403.569 nM -0.555647516294411 0.281292462543528 no 2414 0.289225920889163 3389 1269246 A methoxyflavone. YNL221C POP1
SGTC_3060 1327-0027 12.5 µM -0.558149062087061 0.280443321473146 no 2415 0.288371300337242 3391 16000455 YPR107C YTH1
SGTC_1698 5-fluorocytosine 1.055 µM -0.558774106020983 0.280231346397875 no 2416 0.288157948264095 3475 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1830 st055982 50.3 µM -0.559726065460847 0.279908651619133 no 2417 0.287833150234957 3450 455313 An antimicrobial agent.
SGTC_433 pimozide 108 µM -0.560212173367477 0.279743940513916 no 2418 0.287667362314814 3302 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_415 dibenzyl ketone 100 µM -0.560337263059085 0.279701563168861 no 2419 0.287624707566524 3414 7593
SGTC_985 1493-0307 8.71 µM -0.560497348220368 0.279647334754722 no 2420 0.287570123958437 3488 3278274
SGTC_31 0508-1974 57.237 µM -0.561223430040744 0.279401440588284 no 2421 0.287322616189191 3448 6810525
SGTC_2381 9035592 200 µM -0.562186731526373 0.279075372028092 no 2422 0.286994400305642 3410 4749657
SGTC_2576 guaiol 23.12 µM -0.56228066666089 0.279043585766229 no 2423 0.286962404251533 3395 227829
SGTC_3261 9137475 49.47 µM -0.562484977528456 0.278974456066702 no 2424 0.286892818004976 3353 17027690
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.562728326040473 0.278892128638248 no 2425 0.286809946360022 3369 6708630 An antioxidant.
SGTC_1439 4092-1168 46 µM -0.562754002890047 0.278883442572358 no 2426 0.28680120284357 3432 2886240
SGTC_1706 st031321 9.9705 µM -0.563537937778971 0.278618313363626 no 2427 0.286534317077499 3471 6103185
SGTC_614 0462-0418 107 µM -0.564013868363813 0.278457412067243 no 2428 0.286372346963075 3358 5188303
SGTC_2736 butenafine 14.65 µM -0.564061783115153 0.278441215689342 no 2429 0.286356042880349 3396 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_151 3013-0144 2.285 µM -0.564195220497489 0.278396112953994 no 2430 0.286310640101802 3466 906558 YHR107C CDC12
SGTC_1089 terbinafine 2.25 µM -0.564443394652946 0.278312237885206 no 2431 0.28622620661685 3463 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1442 4112-3290 3 µM -0.565701537841212 0.277887214625916 no 2432 0.285798344824323 3444 704353
SGTC_2378 9074213 121.43 µM -0.566270358774227 0.277695160803838 no 2433 0.285605003510837 3455 657714
SGTC_786 4544-0069 423 µM -0.566321476251585 0.277677904932716 no 2434 0.285587631811712 3451 748821 YLR208W SEC13
SGTC_3188 9110789 49.47 µM -0.566354405489584 0.277666789194277 no 2435 0.28557644144726 3514 849217
SGTC_2027 5150920 200 µM -0.571267981762014 0.276010581244723 no 2436 0.283909001072268 3417 786715
SGTC_2142 5622915 118.518 µM -0.571671951556309 0.275874632186133 no 2437 0.283772119979988 3446 5322196
SGTC_160 3453-0671 289.699 µM -0.572433873090337 0.275618310221321 no 2438 0.283514036587358 3407 5322268
SGTC_1223 0764-0573 147 µM -0.573193087041543 0.275363015657421 no 2439 0.283256982265282 3487 1609797
SGTC_1879 gemcitabine 100 µM -0.574126289201867 0.275049375028728 no 2440 0.282941172324737 3452 60750 A nucleoside analog which inhibits DNA replication.
SGTC_231 b-estradiol 524 µM -0.574288573553198 0.274994850723315 no 2441 0.282886270069282 3383 450 A steroid.
SGTC_2245 6637752 200 µM -0.575816443788604 0.274481778014793 no 2442 0.282369628807404 3439 681890
SGTC_851 0394-0702 453 µM -0.57617113932523 0.274362735625803 no 2443 0.282249755331687 3499 762646
SGTC_3352 9151559 45.5865 µM -0.576815653191277 0.274146490091592 no 2444 0.282031997087926 3416 17159339
SGTC_3133 9127736 49.47 µM -0.577394509908701 0.273952345457222 no 2445 0.281836491042613 3504 27243420
SGTC_844 0330-0132 15.3 µM -0.577678695805074 0.273857056304668 no 2446 0.281740532544233 3511 2828079
SGTC_417 st075190 100 µM -0.578879738831741 0.27345452079852 no 2447 0.281335161159063 3532 222757
SGTC_2748 diazoxide 86.69 µM -0.579670929376173 0.273189509508566 no 2448 0.281068275500277 3424 3019 A potassium channel activatior.
SGTC_1263 0774-1208 64.8 µM -0.580815958529423 0.272806204554904 no 2449 0.280682249169938 3556 906585
SGTC_3233 9132340 49.47 µM -0.581769537600382 0.2724871923304 no 2450 0.28036096269806 3416 17682950
SGTC_2337 9009472 200 µM -0.583151560304366 0.272025176750633 no 2451 0.27989563834252 3565 5742383
SGTC_3104 9120930 49.47 µM -0.584983560779634 0.271413332911683 no 2452 0.279279385263529 3519 17014836
SGTC_1916 st067606 49.2 µM -0.585809703343896 0.271137645768474 no 2453 0.279001701147525 3456 19590279
SGTC_2334 9017922 200 µM -0.587008762682 0.270737763346684 no 2454 0.278598910808234 3473 3163164
SGTC_2673 kobusone 100 µM -0.587579961240958 0.27054737406795 no 2455 0.27840713231743 3540 6710676 An epoxy ketone and protein crosslinker.
SGTC_226 1,3-diallylurea 8.28947 mM -0.588933539805179 0.270096472695876 no 2456 0.277952928712187 3450 74537 YKL182W FAS1
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.594024063817224 0.268404100149002 no 2457 0.276248009114406 3459 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_312 4092-0653 6.84 µM -0.594415366727205 0.268274230403423 no 2458 0.276117166538026 3497 1148278
SGTC_3166 9102297 49.47 µM -0.595322696649748 0.267973217842605 no 2459 0.275813893657019 3463 25237072
SGTC_1437 4092-1038 11.6 µM -0.595390209535024 0.267950826806833 no 2460 0.275791334179061 3496 3977136
SGTC_2664 lyso-paf C-16 73.48 µM -0.595692184866472 0.26785068648838 no 2461 0.275690440010075 3484 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2504 purpurogallin 52.29 µM -0.59587665764061 0.267789521356814 no 2462 0.275628814012842 3418 5281571 An antioxidant.
SGTC_2696 st077691 74.316 µM -0.59831341638816 0.266982232922744 no 2463 0.27481541309731 3508 757133
SGTC_2458 5808907 16.39 µM -0.598786567183337 0.266825622579999 no 2464 0.274657610548879 3597 2731747
SGTC_1505 k297-0037 20.6 µM -0.600603461145557 0.266224672235163 no 2465 0.27405206606195 3435 4089396
SGTC_43 0570-0105 72.5 µM -0.601271289573254 0.266003955656506 no 2466 0.273829654424837 3541 1114046 YDL195W SEC31
SGTC_143 4032-1194 15.74 µM -0.602065348983686 0.265741640558007 no 2467 0.273565319395397 3530 1806963
SGTC_3030 9087619 49.47 µM -0.60314897856152 0.265383878554279 no 2468 0.273204793010255 3473 25236973
SGTC_2884 9058502 51.95 µM -0.603359506766095 0.265314400706178 no 2469 0.273134777047346 3527 6471554
SGTC_1075 aripiprazole 15.2 µM -0.605128736980235 0.264730890045764 no 2470 0.272546730722655 3528 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2394 5221648 200 µM -0.605512122760737 0.264604531479832 no 2471 0.272419386123185 3554 788586
SGTC_2147 5545932 89.7195 µM -0.606905014679412 0.264145712239276 no 2472 0.27195697499503 3510 797404
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.607630284231152 0.263906968664092 no 2473 0.271716355257407 3507 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1657 st012939 43.4 µM -0.607800033558569 0.263851106623479 no 2474 0.271660053518952 3552 24207257
SGTC_2630 antimycin a 100 µM -0.608565293351493 0.263599345602347 no 2475 0.271406307523154 3493 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1357 1503-1303 39.5 µM -0.608633191851364 0.263577013755847 no 2476 0.271383799341127 3527 292895
SGTC_1070 indatraline 8.81 µM -0.608675946762421 0.263562952142125 no 2477 0.271369626672835 3515 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.610005553517804 0.263125850439161 no 2478 0.270929064379498 3531 16486 A toxic proline analog.
SGTC_2922 7999257 32.47 µM -0.610871140868216 0.262841492023581 no 2479 0.270642445824908 3527 2988377
SGTC_2 0422-0095 29 µM -0.616920412302769 0.260858611958142 no 2480 0.268643611156039 3459 6790840
SGTC_3090 9117696 49.47 µM -0.617121031582841 0.260792983387272 no 2481 0.268577448700642 3469 7923821
SGTC_1232 0279-0259 161 µM -0.621504010732746 0.259361302803058 no 2482 0.267134028209031 3555 1560000
SGTC_1811 st050069 61.5 µM -0.622353471306682 0.259084300795225 no 2483 0.266854734123123 3541 3877702
SGTC_2708 st078559 56 µM -0.623385061345342 0.258748113688068 no 2484 0.26651575619518 3504 17250902
SGTC_1246 0422-0085 105 µM -0.624454533066596 0.25839981976183 no 2485 0.266164560512687 3564 264295
SGTC_286 k060-0067 22.9 µM -0.625413693922153 0.258087657416812 no 2486 0.265849788403614 3513 5985051
SGTC_1522 st012842 45.6 µM -0.62544190972232 0.258078477445198 no 2487 0.265840531555542 3503 3491067 YOR116C RPO31
SGTC_795 0685-0265 78 µM -0.626863324730569 0.25761624125691 no 2488 0.265374414868246 3625 302754
SGTC_1097 itavastatin 7.23 µM -0.627304702566876 0.257472795183637 no 2489 0.265229760741227 3572 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1989 st071868 50.2 µM -0.62958992353707 0.256730771392538 no 2490 0.264481458976175 3559 16414057
SGTC_408 cantharidin 100 µM -0.630262781387874 0.256512503106293 no 2491 0.26426133477436 3503 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1411 3909-8223 150 µM -0.630408319681251 0.256465304674038 no 2492 0.264213734465502 3583 X1411
SGTC_677 0929-0063 136 µM -0.631331314337256 0.256166080572812 no 2493 0.26391195801079 3532 1539583
SGTC_171 k064-0041 9.68 µM -0.632010807926191 0.255945913074286 no 2494 0.263689907454036 3492 53325
SGTC_2429 5902844 64.44 µM -0.632388439216382 0.255823596800993 no 2495 0.263566543177292 3555 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_3010 9080089 71.4286 µM -0.633485852983417 0.25546831337264 no 2496 0.263208208181628 3580 17027233
SGTC_3220 9131269 49.47 µM -0.634866279449623 0.255021772066656 no 2497 0.262757815628969 3611 17722206
SGTC_2459 5811157 9.22 µM -0.635018827679892 0.254972450727765 no 2498 0.262708067828389 3551 2870684 YBR192W RIM2
SGTC_3214 9129694 49.47 µM -0.63510593656666 0.254944289238255 no 2499 0.262679662741069 3552 17158655
SGTC_1802 st050112 57.9 µM -0.636530784077167 0.254483880496467 no 2500 0.262215261464096 3567 4662563
SGTC_2799 7812892 81.82 µM -0.637699726015009 0.254106487694626 no 2501 0.261834581969002 3576 20205235
SGTC_1776 st049249 45.9 µM -0.638257654215578 0.253926464174352 no 2502 0.261652986169415 3555 1822314
SGTC_3336 9143619 71.43 µM -0.639034797917832 0.253675819225486 no 2503 0.261400147344736 3610 45595730
SGTC_735 3076-0345 636 µM -0.639792602577085 0.253431536697978 no 2504 0.261153721242715 3616 2888990
SGTC_255 tunicamycin 200.472 nM -0.640018803055146 0.253358643687145 no 2505 0.261080187565961 3544 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2695 st077686 51.995 µM -0.640473794437724 0.253212056286317 no 2506 0.26093231035414 3553 2876092
SGTC_3210 9128157 49.47 µM -0.640941986331572 0.253061262567036 no 2507 0.26078018781076 3507 17590849
SGTC_3165 9101544 49.47 µM -0.641648458912413 0.252833813639731 no 2508 0.26055073071515 3578 5002184
SGTC_2271 7849410 118.62 µM -0.64207773619778 0.252695660350503 no 2509 0.26041135539946 3580 972430
SGTC_85 0868-0259 160.055 µM -0.642582016869967 0.252533419694852 no 2510 0.260247677474001 3504 83173
SGTC_877 0771-0151 33.1 µM -0.64326170375469 0.252314833010024 no 2511 0.260027150630932 3556 6166523
SGTC_1605 st000082 49.1 µM -0.643351612868411 0.252285925792562 no 2512 0.259997986514892 3577 1114022
SGTC_491 tetrandrine 80.3 µM -0.644844145359273 0.251806307939132 no 2513 0.259514095363311 3582 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2032 5185112 25.99 µM -0.645430134808028 0.251618134846404 no 2514 0.259324240049168 3524 5718189
SGTC_362 0310-0100 9.03 µM -0.646797839472734 0.25117922632414 no 2515 0.258881395428235 3597 790235
SGTC_1939 st074455 53.6 µM -0.64706676999803 0.251092971802108 no 2516 0.258794365345491 3615 1644229
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.64758747147552 0.250926010925917 no 2517 0.258625901331985 3661 94937 An inhibitor of serotonin biosynthesis.
SGTC_530 4358-1714 28 µM -0.647680137097538 0.250896304219503 no 2518 0.258595926915137 3586 1564641
SGTC_2850 9015429 58.44 µM -0.648488490741187 0.250637241513152 no 2519 0.258334526222062 3575 6457570
SGTC_2585 alliin 100 µM -0.648548473064773 0.250618023913057 no 2520 0.258315134946184 3667 87310 A garlic compound which reacts with lipids.
SGTC_1269 0831-0796 3.05 µM -0.64944861924321 0.250329721901276 no 2521 0.258024223456594 3602 927758
SGTC_153 4077-0274 519.67 µM -0.651114642010587 0.249796586425949 no 2522 0.257486242701129 3699 3121976
SGTC_2518 prenyletin 46.28 µM -0.651479539089813 0.249679898096358 no 2523 0.25736849044976 3536 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2000 st075254 36.4 µM -0.651700464948037 0.249609263564505 no 2524 0.257297211299472 3580 17234175
SGTC_301 4119-0100 24.5 µM -0.652848714475057 0.24924231564368 no 2525 0.256926907304501 3600 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3263 9137018 49.47 µM -0.653234091511912 0.249119224416971 no 2526 0.256802687564036 3563 43844957
SGTC_817 1391-0715 46 µM -0.654019201146043 0.248868556806981 no 2527 0.256549717558872 3540 1353946
SGTC_1336 1486-0901 104 µM -0.654204516201762 0.248809409525266 no 2528 0.256490026175095 3574 5006114
SGTC_3068 9116768 49.47 µM -0.656245803185502 0.248158384477057 no 2529 0.255832991283142 3589 41904888
SGTC_1656 st012921 11 µM -0.656537542587169 0.24806541466147 no 2530 0.255739160085854 3557 6732821
SGTC_586 0957-0265 8.15 µM -0.656889021380547 0.247953432127139 no 2531 0.255626138969217 3525 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_3354 9151612 71.43 µM -0.656895495308603 0.247951369761096 no 2532 0.255624057465049 3599 27261949
SGTC_2260 7964312 200 µM -0.657336928985111 0.247810766095289 no 2533 0.255482148126934 3652 231951
SGTC_2618 avocadyne 43.43 µM -0.659936040699049 0.246983771406351 no 2534 0.254647437329072 3567 3015189
SGTC_1488 4013-0813 75.9 µM -0.661310089499478 0.246547169076106 no 2535 0.254206736173227 3589 2910057
SGTC_98 0074-0023 107.663 µM -0.662581116930799 0.246143670083797 no 2536 0.25379943361662 3586 3563821
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.662717330981169 0.246100448740059 no 2537 0.253755803964329 3494 88881 An O-methylated flavonoid and antioxidant.
SGTC_1119 parthenolide 318.541 nM -0.663424535344395 0.245876114995262 no 2538 0.253529348204514 3671 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1015 4130-4525 82 µM -0.665071528826157 0.245354094533028 no 2539 0.253002371969802 3585 1363237
SGTC_1274 0865-0114 173 µM -0.66537448709922 0.245258135733283 no 2540 0.252905499465736 3621 870624
SGTC_295 k015-0027 31 µM -0.665920381414258 0.245085280479431 no 2541 0.252730996174691 3594 3887424
SGTC_2068 5226020 147 µM -0.666130799421121 0.245018669959042 no 2542 0.252663749842077 3649 1810509
SGTC_2441 5730946 39.09 µM -0.66640127011342 0.24493306329754 no 2543 0.252577325446119 3635 1774275
SGTC_1596 piperlongumine 63 µM -0.666788226719832 0.24481061567621 no 2544 0.252453707003919 3639 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3032 9089427 49.47 µM -0.667089678036059 0.244715247981718 no 2545 0.252357426464757 3602 17173707
SGTC_2195 6536160 144.242 µM -0.667242078054581 0.244667042044157 no 2546 0.252308758788559 3520 3834386
SGTC_3282 9108498 15.4605 µM -0.667447010855423 0.244602227424975 no 2547 0.252243323007493 3587 16459645
SGTC_3203 9113543 49.47 µM -0.667692907331703 0.244524469326101 no 2548 0.252164819189576 3642 17018012
SGTC_209 4077-0173 175.592 µM -0.672062006868937 0.243145082821385 no 2549 0.250772111184575 3570 15993494
SGTC_591 4299-0174 154 µM -0.672908772416659 0.242878234528945 no 2550 0.250502665452741 3598 5509088
SGTC_1840 st055363 71 µM -0.673331857583734 0.242744963562682 no 2551 0.250368094783508 3582 676033
SGTC_2643 anethole 100 µM -0.673980890917574 0.242540596344445 no 2552 0.250161731303675 3623 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2020 4017018 200 µM -0.674381830438586 0.24241439533106 no 2553 0.250034295618782 3648 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1379 2144-0755 36.5 µM -0.674490759476595 0.242380114623352 no 2554 0.249999679274407 3662 5392327
SGTC_1777 st045864 34.765 µM -0.674490759476595 0.242380114623352 no 2555 0.249999679274407 3642 4691462
SGTC_2088 5278280 127.392 µM -0.674563158580056 0.242357331587141 no 2556 0.249976673112855 3670 791502
SGTC_2996 9066192 71.4286 µM -0.675015773119551 0.24221492611033 no 2557 0.249832871895969 3634 6472854
SGTC_3262 9137218 49.47 µM -0.675164808217776 0.242168045334997 no 2558 0.249785531221431 3510 17650664
SGTC_427 1354-0053 47.3 µM -0.676288825249654 0.241814630819451 no 2559 0.249428643132583 3688 6813657
SGTC_745 0469-0705 296 µM -0.677291416237017 0.241499631505547 no 2560 0.249110538002512 3717 3486736
SGTC_3310 9130229 44.1445 µM -0.679313042470557 0.240865144630146 no 2561 0.248469767123301 3654 7761258
SGTC_2445 5742597 35.57 µM -0.68077947667068 0.240405472730914 no 2562 0.248005519082627 3609 1774255
SGTC_1970 st070122 35.8 µM -0.680881576950205 0.240373485940334 no 2563 0.247973213119622 3677 102928
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.681720991758556 0.240110595272234 no 2564 0.247707695627193 3645 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3084 9116877 49.47 µM -0.68461796770162 0.239204515924123 no 2565 0.246792512938658 3575 27241325
SGTC_3264 9137442 49.47 µM -0.684656566067718 0.239192456242889 no 2566 0.246780331573723 3692 17015726
SGTC_2951 9072950 58.06 µM -0.685703149595239 0.238865588145908 no 2567 0.246450160119242 3670 16488155
SGTC_1131 3454-3128 32.3 µM -0.685986145665522 0.238777245027519 no 2568 0.246360922469191 3708 710982
SGTC_2284 7945075 39.21 µM -0.68632639439452 0.238671052967114 no 2569 0.246253654170886 3720 1245402
SGTC_562 3772-2733 112 µM -0.686820489187393 0.238516891377866 no 2570 0.246097928287615 3665 2876874 YIL048W NEO1
SGTC_2187 6125751 200 µM -0.688242676682442 0.238073461740506 no 2571 0.245649986610773 3650 874498
SGTC_60 0986-0278 202 µM -0.689911830960144 0.237553606161662 no 2572 0.245124817654882 3495 3110598
SGTC_2102 5377816 72.7585 µM -0.691068885818227 0.237193609101498 no 2573 0.24476112610781 3671 1379702
SGTC_713 1488-1073 324 µM -0.691075513608274 0.237191547846011 no 2574 0.244759043663201 3639 3312542
SGTC_3059 1327-0034 3 µM -0.691165606887263 0.237163529638516 no 2575 0.24473073739648 3629 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1205 4161-2785 76 µM -0.691623147271918 0.237021266721772 no 2576 0.244587010704583 3658 3498106
SGTC_2477 5967686 25.23 µM -0.694890429991816 0.236006735817318 no 2577 0.243561985281563 3680 776118
SGTC_1494 4358-1428 177 µM -0.694967150802827 0.235982941864566 no 2578 0.243537944023115 3693 1564571
SGTC_2235 salicylic acid 500 µM -0.695383109284636 0.235853960816247 no 2579 0.24340762145318 3668 338 A COX inhibitor and kinase inhibitor.
SGTC_1838 st055369 84.5 µM -0.695552058377695 0.235801583920762 no 2580 0.243354699336766 3653 676036
SGTC_918 glabranin 770.725 nM -0.698194309028917 0.234983279319112 no 2581 0.242527842513288 3695 124049 Also referred to as licorice root.
SGTC_1419 3993-2473 62.6 µM -0.698944544891254 0.234751217719789 no 2582 0.242293343947258 3726 704026
SGTC_783 0848-0141 92.7 µM -0.699785029640073 0.234491391047137 no 2583 0.242030782613739 3665 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2930 9013230 14.89 µM -0.699945440722984 0.234441819800442 no 2584 0.24198068889724 3661 2995857
SGTC_644 1498-1197 63.3 µM -0.699995044151853 0.234426492209114 no 2585 0.241965199708834 3700 6741615
SGTC_1825 st052143 62.6 µM -0.702573787253438 0.23363041788978 no 2586 0.241160701452201 3693 674173
SGTC_2308 7584454 197.62 µM -0.70350811824051 0.233342354352073 no 2587 0.240869574652778 3721 893577
SGTC_1736 st036774 51 µM -0.704676998380172 0.232982254643259 no 2588 0.24050563440613 3720 1272247
SGTC_219 mitoxanthrone 164.414 µM -0.705069267907381 0.232861476433263 no 2589 0.240383565270516 3681 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_488 nitrendipine 139 µM -0.70660882055674 0.232387790685951 no 2590 0.239904802983555 3711 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1183 1254-0324 198 µM -0.709070020741492 0.231631649235413 no 2591 0.239140512899649 3717 5799357
SGTC_3013 9080133 71.4286 µM -0.709411426923095 0.231526869230978 no 2592 0.239034599351373 3750 17050193
SGTC_1843 st055809 45.5 µM -0.709900735451434 0.231376743019179 no 2593 0.238882847168747 3689 16413835
SGTC_62 0180-0423 3.232 µM -0.71079794703058 0.231101607940005 no 2594 0.238604726504017 3663 30102 YGL099W LSG1
SGTC_508 roscovitine 141 µM -0.712241630911518 0.230659277503869 no 2595 0.238157580757938 3736 160355 A CDKinase inhibitor.
SGTC_1615 st002656 86.5 µM -0.714915361245241 0.229841323625235 no 2596 0.237330672222722 3709 1584458
SGTC_1951 sophoraflavanone G 9.2 µM -0.714928399951232 0.229837338776634 no 2597 0.237326643589623 3716 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2101 5377231 179.231 µM -0.71504316765106 0.229802265499347 no 2598 0.2372911848692 3708 2844213
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.716329779709338 0.229409279025012 no 2599 0.236893871385736 3757 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3226 9131256 49.47 µM -0.716927049348065 0.229226975368745 no 2600 0.23670955532878 3606 17178073
SGTC_1591 genipin 88.4 µM -0.717320464011466 0.229106938431178 no 2601 0.236588191558528 3700 442424 A DNA cross-linking agent.
SGTC_1214 0358-0031 63.7 µM -0.717554148832286 0.229035654249704 no 2602 0.23651611876646 3764 4301366
SGTC_2272 7805186 180 µM -0.720232669165255 0.228219476608961 no 2603 0.23569087628335 3673 2956062 YPR165W RHO1
SGTC_1652 st011932 78 µM -0.72083727364808 0.228035472738521 no 2604 0.235504819738178 3657 1551076
SGTC_675 1309-0189 238 µM -0.7222635200429 0.227601743097986 no 2605 0.235066238388796 3722 4246530
SGTC_48 0382-0018 55 µM -0.722801042940718 0.227438399924104 no 2606 0.234901063247751 3797 762596
SGTC_3284 9108171 64.8615 µM -0.723616003642671 0.227190874576645 no 2607 0.234650756773735 3690 8687505
SGTC_2258 7960471 200 µM -0.724324299062741 0.2269758697082 no 2608 0.234433331258437 3671 2974708
SGTC_2593 nobiletin 86.24 µM -0.725052167767361 0.226755042914992 no 2609 0.234210013514141 3693 72344 An anti-infammatory.
SGTC_2397 5161689 200 µM -0.725165658458249 0.226720622103665 no 2610 0.234175203997588 3755 2259942
SGTC_216 k038-0035 28.382 µM -0.726109024054605 0.226434621065726 no 2611 0.233885968688187 3644 4444231 YPR107C YTH1
SGTC_1106 tegaserod maleate 11.7 µM -0.72613764299697 0.226425947819239 no 2612 0.233877197232846 3760 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_867 0518-0118 155 µM -0.727435528694183 0.226032808270974 no 2613 0.233479598258293 3742 6848158
SGTC_3178 9107506 49.47 µM -0.727937875178348 0.225880747298204 no 2614 0.233325808327895 3730 8897194
SGTC_2743 auranofin 4.32 µM -0.728133296398692 0.225821608658196 no 2615 0.233265996651928 3669 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1620 st003704 16.5 µM -0.729964687229592 0.225267816382212 no 2616 0.232705884990564 3693 2834414
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.730276919785558 0.225173477523946 no 2617 0.232610466579027 3741 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_63 0099-0242 26.702 µM -0.730394403705822 0.225137986384125 no 2618 0.232574569071943 3762 3898502 YLR359W ADE13
SGTC_2242 6630449 61.2675 µM -0.730412652540625 0.225132473812398 no 2619 0.232568993370987 3778 691249 YDR170C SEC7
SGTC_1014 4130-3005 69.3 µM -0.730752389013152 0.225029860858976 no 2620 0.23246520475512 3733 743608
SGTC_2328 6201408 200 µM -0.731058665625133 0.224937376739552 no 2621 0.232371660122708 3725 2890418
SGTC_1969 st069479 40.1 µM -0.731235397377189 0.224884020142877 no 2622 0.232317691299424 3690 3895485
SGTC_628 1636-0253 16 µM -0.731806694483282 0.224711590498641 no 2623 0.232143281213769 3729 4456143
SGTC_702 1488-0190 94 µM -0.734077431228846 0.22402697552829 no 2624 0.231450773796439 3750 949357
SGTC_816 0325-0417 81.3 µM -0.734902058187085 0.223778648511663 no 2625 0.231199572405075 3747 68101
SGTC_1519 esterone 74 µM -0.735948886791703 0.223463633513897 no 2626 0.230880902231555 3730 698 A steroid.
SGTC_409 arachidonic acid 100 µM -0.736192337418448 0.223390409748914 no 2627 0.230806827412575 3739 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2828 7998861 71.43 µM -0.736270002282821 0.223367053003039 no 2628 0.230783199086302 3634 2988188
SGTC_1699 st031318 29.054 µM -0.737932469488979 0.222867419930973 no 2629 0.230277743413429 3804 5340658
SGTC_1267 0828-0272 9.49 µM -0.739099351827126 0.222517109131185 no 2630 0.229923335208931 3772 745334
SGTC_318 1488-0629 67.2 µM -0.739698488691013 0.222337363776884 no 2631 0.229741482669151 3789 3662576
SGTC_29 0299-0004 12.984 µM -0.741222863067439 0.221880414194179 no 2632 0.229279161520428 3636 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.74175634935999 0.221720622039163 no 2633 0.229117485991259 3740 616764
SGTC_3025 9087895 49.47 µM -0.741825473758607 0.221699922408541 no 2634 0.229096542197783 3757 17173641
SGTC_2790 5423970 71.43 µM -0.743564575373519 0.221179503609764 no 2635 0.228569970549653 3782 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2116 5511452 16.8835 µM -0.744285707186263 0.220963913119334 no 2636 0.228351823126087 3763 870744
SGTC_2097 5376186 200 µM -0.746588768798936 0.220276192936774 no 2637 0.227655914975979 3691 742755
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.748783678548152 0.219621911764528 no 2638 0.226993799323786 3782 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2791 5663188 71.43 µM -0.749226964563097 0.21948990811961 no 2639 0.226860209756218 3722 54690634
SGTC_2159 5658611 73.75 µM -0.749800532840886 0.219319176112043 no 2640 0.226687423897813 3745 793844
SGTC_2297 7971671 152.32 µM -0.750111061158637 0.219226774118981 no 2641 0.226593909097676 3733 909016
SGTC_1715 st032160 10.2275 µM -0.750132499966609 0.21922039553127 no 2642 0.22658745365978 3663 5289825
SGTC_245 methotrexate 289.6 µM -0.752014598969954 0.218660839392299 no 2643 0.226021139720056 3751 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2905 7799065 20.05 µM -0.754175353590403 0.218019452604997 no 2644 0.22537196742324 3677 1296806
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.754805658961147 0.217832560688537 no 2645 0.225182798968114 3807 65057 A dermal irritant. YDR527W RBA50
SGTC_452 diindolylmethane 8 µM -0.755133520745709 0.217735382898524 no 2646 0.225084436033228 3736 3071 Inhibits expression of several cancer promoting factors.
SGTC_172 1112-0046 2.638 µM -0.755222962975354 0.21770887668523 no 2647 0.225057606391359 3726 2802135 YIL048W NEO1
SGTC_79 0052-0007 94.094 µM -0.755775252839392 0.217545246775256 no 2648 0.224891978271279 3775 2801472
SGTC_1322 1348-1070 12 µM -0.758520224582626 0.216733032973215 no 2649 0.224069805099862 3732 6758089
SGTC_1886 st057356 49.9 µM -0.759104515307745 0.216560372959203 no 2650 0.223895019158969 3752 24207747
SGTC_1085 doxorubicin 7.67 µM -0.759999724327481 0.216295989891734 no 2651 0.223627374828517 3765 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1164 k060-0068 93.7 µM -0.761030111501068 0.215991915939309 no 2652 0.223319541072138 3796 5963676
SGTC_1764 st044502 93.5 µM -0.761508062367648 0.215850953652818 no 2653 0.22317683257202 3801 8407
SGTC_1659 st012954 42.1 µM -0.762325260616521 0.215610060514886 no 2654 0.2229329505296 3762 24207262
SGTC_224 benfluorex 43.875 µM -0.762933255074362 0.215430937506579 no 2655 0.222751601133732 3753 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_984 1492-0255 2.91 µM -0.764816035603682 0.214876793964224 no 2656 0.222190548828708 3744 1585198
SGTC_1495 4469-0029 237 µM -0.765063781787339 0.21480393853021 no 2657 0.222116782697256 3782 793680
SGTC_319 1348-1596 45.5 µM -0.767219116212279 0.214170718920931 no 2658 0.221475624513506 3833 5380505
SGTC_50 0929-0078 56.389 µM -0.76739024616113 0.214120488927551 no 2659 0.22142476300436 3683 1377751
SGTC_3323 9138564 53.9225 µM -0.771544640058573 0.212903197705199 no 2660 0.220192086721921 3779 43912313 YNL103W MET4
SGTC_1090 efavirenz 20.7 µM -0.772304131836174 0.212681094254263 no 2661 0.219967159402735 3851 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.772567428066007 0.212604128303258 no 2662 0.219889213682029 3808 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1065 prochlorperazine maleate 2.48 µM -0.772741181384218 0.212553346173556 no 2663 0.219837784759421 3828 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2198 6589944 200 µM -0.773194667255607 0.212420841202558 no 2664 0.21970359084562 3786 5290268
SGTC_3062 9077494 49.47 µM -0.773784094790404 0.212248687309731 no 2665 0.219529239875804 3775 16459633
SGTC_2732 terfenadine 20 µM -0.774655642494897 0.211994284176207 no 2666 0.219271584264467 3789 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_230 MPP+ 141.667 µM -0.774727853386508 0.211973213956192 no 2667 0.219250244361424 3784 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1401 3807-4679 7.6 µM -0.775672589030807 0.211697664966215 no 2668 0.2189711642419 3764 3291456
SGTC_3316 9136639 10.545 µM -0.776555160268452 0.211440436834935 no 2669 0.218710632529936 3837 4903665
SGTC_1800 st050079 29.0735 µM -0.777611699192701 0.211132746119788 no 2670 0.21839898096054 3724 3645560
SGTC_1998 st075797 76.8 µM -0.778017079502835 0.211014758866056 no 2671 0.218279472219461 3753 24208315
SGTC_2107 5363541 170.161 µM -0.778202028712164 0.210960941641337 no 2672 0.21822496051331 3751 244052
SGTC_2716 st080858 38.6235 µM -0.780079787646781 0.210414999959234 no 2673 0.217671956410671 3792 5296050
SGTC_1741 st038134 10.228 µM -0.78062691740057 0.210256083030523 no 2674 0.217510977757263 3846 1272587
SGTC_689 0833-0039 98 µM -0.781524727047289 0.209995461926385 no 2675 0.217246969651902 3778 5374726
SGTC_398 bronopol 33.3 µM -0.78162225806371 0.209967161523792 no 2676 0.217218301026046 3723 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2034 5197015 53.07 µM -0.782393342227031 0.209743496313145 no 2677 0.216991722656774 3789 780676
SGTC_258 haloperidol 50.781 µM -0.78306419154187 0.209549019814539 no 2678 0.216794708843981 3832 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_211 3455-0679 143.504 µM -0.783240486895994 0.209497930110841 no 2679 0.216742951910161 3835 748649
SGTC_1030 k029-0042 36.7 µM -0.783375493828913 0.209458810585026 no 2680 0.216703321296387 3811 6080581
SGTC_2122 5258151 111.688 µM -0.783866890366719 0.209316460121154 no 2681 0.216559109678273 3812 2173356
SGTC_2049 5262831 67.185 µM -0.784219494606339 0.209214350872133 no 2682 0.216455664075783 3859 763417
SGTC_1305 1181-0477 144 µM -0.784672386867387 0.209083242645261 no 2683 0.21632283834032 3824 6252086
SGTC_103 0844-0104 51.839 µM -0.78479404774806 0.209048031162908 no 2684 0.216287165277431 3802 5375804
SGTC_3266 9136860 49.47 µM -0.785605807412221 0.208813178478576 no 2685 0.216049230567174 3727 4871271 YPR165W RHO1
SGTC_912 3474-0017 2.18 µM -0.785657289517776 0.208798289276662 no 2686 0.216034145772155 3840 3360550
SGTC_1033 k072-0102 21.3 µM -0.786805930357683 0.208466252190389 no 2687 0.215697740696003 3763 5965931
SGTC_567 1080-0542 68.4 µM -0.786960845508571 0.208421494779476 no 2688 0.215652393593315 3714 5950415
SGTC_3257 9139206 32.98 µM -0.788396927531664 0.208006858065653 no 2689 0.215232283717071 3835 4910041
SGTC_2292 7671323 168.05 µM -0.790313723768994 0.207454185246752 no 2690 0.214672286990137 3847 937504
SGTC_2669 eugenol 100 µM -0.790495148944882 0.207401919649749 no 2691 0.214619327081081 3773 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_95 0471-0001 561.058 µM -0.79066261310962 0.207353682899033 no 2692 0.21457044927797 3770 4015405
SGTC_945 3381-0768 11.3 µM -0.792374419138862 0.206860991025769 no 2693 0.214071195324983 3843 1126236 YIL048W NEO1
SGTC_1113 artemisinin 1.17947 µM -0.79247277770432 0.206832702538764 no 2694 0.214042529274298 3822 2240 An anti-malaria and mitochondrial poison.
SGTC_668 1682-0499 62.6 µM -0.793874402008362 0.206429836236785 no 2695 0.213634276582694 3841 682214
SGTC_927 2425-1185 123 µM -0.794718092805944 0.206187560059245 no 2696 0.213388752689916 3796 730375
SGTC_2355 9061122 103.12 µM -0.794742012572884 0.206180693662538 no 2697 0.213381794156583 3858 5302957
SGTC_1365 1672-3266 55.4 µM -0.795573458078219 0.205942103579495 no 2698 0.213139999387941 3819 6415873
SGTC_981 1488-1094 54.9 µM -0.796701463402348 0.20561867517218 no 2699 0.212812216923168 3807 3449522
SGTC_938 3126-1755 342 µM -0.798551158582792 0.20508897261448 no 2700 0.212275358891708 3864 1777771
SGTC_280 3448-3607 3.04 µM -0.800301785698772 0.204588388257022 no 2701 0.211767984369614 3815 626179
SGTC_624 k048-0052 28 µM -0.80286452504469 0.203856896419137 no 2702 0.211026521108339 3825 6835531
SGTC_2900 5328528 85.29 µM -0.805705786393724 0.203047729871036 no 2703 0.210206256146958 3860 795359
SGTC_45 0kpi-0036 14.9 µM -0.806019249554679 0.202958575899268 no 2704 0.210115874962367 3844 2795021
SGTC_467 ro 31-8220 72.8 µM -0.806956008799666 0.202692285844672 no 2705 0.209845914202977 3774 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_721 1187-1332 279 µM -0.807581014362479 0.202514733358757 no 2706 0.209665909894528 3771 25730
SGTC_1609 st001574 46.4 µM -0.807691069053213 0.202483478493355 no 2707 0.209634223071744 3844 3960012
SGTC_2843 9000894 45.46 µM -0.810330148360076 0.201734860033469 no 2708 0.208875226187775 3766 2242070
SGTC_2349 9023730 187.07 µM -0.811126308330771 0.201509341973138 no 2709 0.208646569554226 3836 4126287
SGTC_1318 1280-3875 124 µM -0.812445538668874 0.201135993154309 no 2710 0.208268012417335 3858 373245
SGTC_2823 7987624 58.44 µM -0.812823177159864 0.20102919598067 no 2711 0.208159722556351 3834 2239440
SGTC_1397 3532-0190 20.1 µM -0.813767218881466 0.200762367303262 no 2712 0.207889158933178 3767 5322280
SGTC_2820 7989630 71.43 µM -0.817786230394818 0.199628794726941 no 2713 0.206739630971933 3779 2984098
SGTC_1250 0485-0349 40.2 µM -0.818374331573665 0.199463242898395 no 2714 0.206571736977467 3872 6842794 YDL195W SEC31
SGTC_1678 st019265 80.2 µM -0.819350792877179 0.199188549402219 no 2715 0.206293150470784 3824 5367020
SGTC_2071 5230951 39.92 µM -0.819680015439898 0.199095985449652 no 2716 0.206199272784899 3891 1799272
SGTC_2268 7933382 153.85 µM -0.820505936083671 0.1988638843441 no 2717 0.205963873322974 3879 935025 YOR257W CDC31
SGTC_572 0960-0087 17.7 µM -0.820521743127788 0.1988594438228 no 2718 0.205959369639295 3872 6796365
SGTC_739 1486-1183 203 µM -0.820640403600931 0.198826111582559 no 2719 0.205925563207783 3819 4346692
SGTC_856 0433-0016 11.3 µM -0.821047675148492 0.198711732863587 no 2720 0.205809556368112 3911 3911780
SGTC_1738 st035555 74 µM -0.82190446428425 0.198471240552061 no 2721 0.205565635995733 3910 5331140
SGTC_1831 st055328 12 µM -0.823060324438997 0.198147080315245 no 2722 0.205236844804299 3828 1103068
SGTC_2678 equilin 100 µM -0.823257327263539 0.198091862900146 no 2723 0.20518083737733 3872 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_889 0919-1524 82.7 µM -0.827660347750673 0.196860177409827 no 2724 0.203931440617151 3912 3905452
SGTC_620 0109-0052 432 µM -0.828063008253637 0.196747770460863 no 2725 0.203817408770244 3849 493037
SGTC_738 1315-0003 72.4 µM -0.831210288877748 0.195870513713953 no 2726 0.202927421714191 3894 6251474
SGTC_2067 5224629 34.075 µM -0.831601973746894 0.195761503816913 no 2727 0.202816823825592 3873 2835000
SGTC_3311 9131146 2.8755 µM -0.833675388450878 0.195185064973278 no 2728 0.20223196530794 3862 4900406 YPR165W RHO1
SGTC_1423 4048-0112 5.59 µM -0.838354172629357 0.193888091902964 no 2729 0.200915909655909 3919 X1423
SGTC_3344 9148862 3.898 µM -0.839500765329032 0.19357105607896 no 2730 0.200594179954955 3918 4905352
SGTC_2847 9005661 71.43 µM -0.839819789485776 0.193482901335683 no 2731 0.200504717986527 3863 2991449
SGTC_3043 9092303 49.47 µM -0.842799450491553 0.192660725907992 no 2732 0.199670307695599 3897 25236084
SGTC_248 streptozotocin 5.23457 mM -0.842948083893674 0.19261976959976 no 2733 0.199628739877746 3884 5300 DNA alkylating agent.
SGTC_1948 st076329 66.6 µM -0.843103861762329 0.192576850327293 no 2734 0.199585179579505 3770 24208413
SGTC_1182 1222-0449 220 µM -0.843268857900379 0.192531397650411 no 2735 0.199539047807246 3893 658318
SGTC_1428 4049-0204 61.7 µM -0.843777547534785 0.192391306526549 no 2736 0.199396862122576 3954 X1428
SGTC_1523 st012844 44.7 µM -0.846061996868034 0.191762947003225 no 2737 0.198759079839426 4036 4274103
SGTC_1911 st060208 74.3 µM -0.846080962242548 0.191757735661633 no 2738 0.198753790158566 3950 688783
SGTC_2742 clothiapine 36.27 µM -0.846762026556626 0.191570648994782 no 2739 0.198563889035733 3837 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2722 naftopidil 47.16 µM -0.847127867032906 0.191470199707289 no 2740 0.198461926956188 3818 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_743 1275-0778 158 µM -0.847473479089319 0.191375334213077 no 2741 0.19836563168892 3897 2849257 YMR203W TOM40
SGTC_793 0488-0545 106 µM -0.848246820622488 0.191163167544571 no 2742 0.198150263553403 3906 292548
SGTC_3339 9145883 14.936 µM -0.848849932342497 0.190997803650882 no 2743 0.197982400793175 3818 2030670
SGTC_1189 1431-2119 7.28 µM -0.849163310305637 0.190911914914768 no 2744 0.197895212910934 3917 3107275
SGTC_2906 7926292 26.41 µM -0.850731843605768 0.190482376983629 no 2745 0.197459164943427 3888 2966319
SGTC_1311 1190-0148 100 µM -0.851639993000913 0.190233954585048 no 2746 0.197206967667877 3957 1961333
SGTC_2625 euphol 100 µM -0.853286642676187 0.189784024890056 no 2747 0.196750182775718 3939 6708538 A triterpene alcohol.
SGTC_2081 5214970 32.255 µM -0.855805850273097 0.189096945611646 no 2748 0.19605258935784 3819 2063512
SGTC_3177 9107506 49.47 µM -0.856089761579649 0.189019608870299 no 2749 0.195974065693873 3829 8897194
SGTC_1256 0570-0116 285 µM -0.856318122301139 0.18895741811149 no 2750 0.195910919955542 3924 410638
SGTC_378 3970-0959 8.33 µM -0.856579591775849 0.188886226141495 no 2751 0.195838634229067 3936 6615653
SGTC_367 0335-0881 7.1 µM -0.857558898056801 0.188619731041022 no 2752 0.195568039549124 3915 23828853
SGTC_1282 0886-0010 32.4 µM -0.858920769868829 0.188249515297841 no 2753 0.195192114793642 3983 2836211 YNL267W PIK1
SGTC_1564 D-Arginine 115 µM -0.862433390540186 0.187296704295838 no 2754 0.194224536366549 3933 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_379 3970-0972 5.9 µM -0.865532211937189 0.186458618018653 no 2755 0.193373371920419 3917 2898042 YBL034C STU1
SGTC_2182 6325192 200 µM -0.866289888610327 0.186254055843489 no 2756 0.19316560492668 3842 736248
SGTC_2194 5927483 104.545 µM -0.867586616666957 0.185904280098774 no 2757 0.192810337800824 3927 760979
SGTC_3058 9093861 49.47 µM -0.8678705626744 0.185827743705761 no 2758 0.192732597863535 3921 17217477
SGTC_3173 9105693 49.47 µM -0.869157395296335 0.185481128687337 no 2759 0.19238052352925 3933 17096658
SGTC_3038 9091290 49.47 µM -0.871397347755227 0.18487874384209 no 2760 0.19176861672805 3916 25236843
SGTC_2442 5158906 48.48 µM -0.871950857606134 0.184730077363108 no 2761 0.191617593577108 3967 1893835
SGTC_1346 1488-2224 62.4 µM -0.874586593064044 0.184023168680041 no 2762 0.190899442616893 3904 3722427
SGTC_2302 7771753 200 µM -0.875631995522711 0.183743257088541 no 2763 0.190615062854676 3957 2203047
SGTC_696 1560-0013 611 µM -0.881346575384241 0.182217842616076 no 2764 0.189065132149827 3996 1650269
SGTC_1170 0310-0127 64.8 µM -0.881439979682205 0.182192975774487 no 2765 0.189039863315976 3967 774975
SGTC_2870 9038528 12.99 µM -0.882940865683168 0.181793688774665 no 2766 0.188634111226896 4015 6463316
SGTC_2526 patulin 37.61 µM -0.883333278575468 0.18168938386373 no 2767 0.188528114257463 4002 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_401 neomycin 50 µM -0.886954524195633 0.180728610235012 no 2768 0.187551692301405 3931 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1946 st076057 65.1 µM -0.8877406447486 0.180520461599447 no 2769 0.18734013862627 3825 953009
SGTC_2254 7938975 95.19 µM -0.888882120261469 0.180218490047668 no 2770 0.187033217771215 4024 2969277
SGTC_3003 9075612 71.4286 µM -0.890020769688422 0.179917582179775 no 2771 0.186727366896727 3983 6501993
SGTC_1188 1403-0014 4.57 µM -0.891165781485165 0.179615311326427 no 2772 0.186420119436274 3965 9614867
SGTC_105 0111-0055 734.78 µM -0.891267476171165 0.179588480457648 no 2773 0.186392846278769 3971 5179370
SGTC_1694 st024011 44.9 µM -0.894605264372361 0.178709245268049 no 2774 0.185499068349153 3979 2787533
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.894926209088181 0.178624845555613 no 2775 0.185413267621474 3968 6728940
SGTC_3348 9149464 3.537 µM -0.896311484854786 0.178260843837766 no 2776 0.185043213451701 3943 1951442
SGTC_419 nsc-638432 893 µM -0.897365670357277 0.177984154443638 no 2777 0.184761912400402 3941 368090
SGTC_2132 5317594 122.667 µM -0.897923550808634 0.177837838614399 no 2778 0.184613154041764 3940 794577
SGTC_2699 st077704 54.6 µM -0.898578361683278 0.177666197569568 no 2779 0.184438644307107 3974 645852
SGTC_3061 glucosamine 200 µM -0.899831821115612 0.177337928591302 no 2780 0.184104878653896 3848 91431 and experimental redox chemotherapeutic
SGTC_2128 5255449 168.493 µM -0.899889063804606 0.177322946431049 no 2781 0.184089645305623 3961 736008
SGTC_2738 aclarubicin 5.55 µM -0.900751540713242 0.177097306626506 no 2782 0.183860219081674 3904 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_348 k064-0012 10.7 µM -0.901505468837372 0.176900213825085 no 2783 0.183659813702976 3876 5066323
SGTC_2061 5245884 80.95 µM -0.902448118486967 0.176653980313987 no 2784 0.183409434876244 3951 573863
SGTC_1709 st033179 39.1045 µM -0.902922131216697 0.176530243368129 no 2785 0.183283611968396 3936 573381
SGTC_585 0kpi-0023 191 µM -0.904069652159849 0.176230919946607 no 2786 0.182979234611729 3890 64601
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.904888349396409 0.176017564509476 no 2787 0.182762269910911 3995 23665772 A membrane-active detergent.
SGTC_1138 3761-0006 1.03 µM -0.904893394017921 0.176016250370176 no 2788 0.182760933523047 3929 12061087
SGTC_2443 5493264 126.67 µM -0.906356083005455 0.175635477470091 no 2789 0.18237370494475 4004 5340055
SGTC_1120 ficusin 1.78878 µM -0.906981970507175 0.175472703571227 no 2790 0.182208165790718 4056 6199 A DNA cross-linker.
SGTC_375 3970-0961 9.27 µM -0.907305708651101 0.175388546868692 no 2791 0.182122578099002 3932 2898222
SGTC_758 0868-0029 16 µM -0.907433122955612 0.175355432155996 no 2792 0.182088900063632 4043 762687
SGTC_2408 sulbentine 18.36 µM -0.91020678754056 0.174635545084278 no 2793 0.181356732620552 3978 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_801 0866-0028 10.1 µM -0.911259962944434 0.174362692317982 no 2794 0.181079208210863 3965 6849771
SGTC_1993 st073995 70.8 µM -0.912783052982 0.173968575166612 no 2795 0.180678326537547 3963 3098394
SGTC_3116 9124943 49.47 µM -0.918265486113413 0.172554625749209 no 2796 0.179239945898507 3980 41905195 YPL160W CDC60
SGTC_2170 morpholine 200 µM -0.919309781259421 0.17228612952693 no 2797 0.178966781573501 4025 121171 Reacts with secondary amines.
SGTC_3298 9116858 71.43 µM -0.919500557897815 0.172237108213677 no 2798 0.178916906974013 4051 2506942
SGTC_1058 3448-5425 97.3 µM -0.923121594040852 0.171308347184514 no 2799 0.177971921244751 3867 7279705
SGTC_86 0417-1630 471.922 µM -0.923316815829136 0.171258365796398 no 2800 0.177921063576912 4015 3634867
SGTC_761 k216-0224 480 µM -0.92374375964898 0.17114909059162 no 2801 0.17780987142482 3989 1340404
SGTC_1920 st075728 45.7 µM -0.926091771391155 0.170548920016808 no 2802 0.177199144957277 3935 3400306
SGTC_2280 7785178 200 µM -0.927307044653008 0.170238816333483 no 2803 0.176883568875669 3994 2954328
SGTC_1220 1838-0075 193 µM -0.929595269929396 0.169655906512276 no 2804 0.176290338705756 3923 5529645
SGTC_1550 gossypolone 36.6 µM -0.929629408388924 0.16964721967613 no 2805 0.176281497736541 4015 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_794 k038-0031 316 µM -0.929939982048813 0.169568204537653 no 2806 0.176201080158899 3999 6624242
SGTC_814 3342-0569 96 µM -0.931573737420977 0.169152938687339 no 2807 0.175778430401604 4052 4346283
SGTC_1405 3909-7894 12 µM -0.931659840720206 0.16913107119031 no 2808 0.175756173452588 4010 7104060
SGTC_2894 9048625 32.47 µM -0.93250963256072 0.168915348488839 no 2809 0.175536605467703 3983 4092861
SGTC_3232 9132874 49.47 µM -0.934748735089673 0.168347791170879 no 2810 0.174958902337368 3963 3784940
SGTC_2967 9089538 49.85 µM -0.936644176020584 0.167868303310631 no 2811 0.174470810152534 4040 728216
SGTC_3160 9100216 49.47 µM -0.937334930064453 0.167693782725515 no 2812 0.174293150337322 3921 17191039
SGTC_305 1682-2595 20.8 µM -0.93826341425393 0.167459383231211 no 2813 0.174054528227199 4039 226033
SGTC_3306 9127676 59.7925 µM -0.940608344352412 0.166868336690408 no 2814 0.173452802086567 4013 41905287
SGTC_744 1594-0068 283 µM -0.941902379365901 0.166542748264586 no 2815 0.173121310919555 4008 668392
SGTC_2917 7979103 53.79 µM -0.942069383836423 0.166500758646384 no 2816 0.173078559032 4088 2980565
SGTC_2069 5228469 200 µM -0.943496801503347 0.166142144593936 no 2817 0.172713425276126 4033 2835210
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.944212896450557 0.16596242618911 no 2818 0.172530433128551 3981 756377
SGTC_770 0389-1121 67.2 µM -0.945206869990549 0.165713176871758 no 2819 0.17227663639952 4145 6753108
SGTC_2532 xanthone 78.9 µM -0.94524296670106 0.165704129798713 no 2820 0.172267424112549 4042 7020 An insecticide.
SGTC_531 3788-1495 174 µM -0.945380571606643 0.165669644221589 no 2821 0.172232308674222 3982 2896655
SGTC_1666 st014829 29 µM -0.94538477828301 0.165668590046948 no 2822 0.172231235243137 4010 3858230
SGTC_676 falcarinol 140 µM -0.946786291923555 0.1653176183325 no 2823 0.171873844164089 4000 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1253 0550-0034 176 µM -0.947287450290936 0.165192233452376 no 2824 0.171746161984817 4060 5969915
SGTC_2186 6124449 200 µM -0.948617625656499 0.164859735274476 no 2825 0.171407561629684 4024 3834182 YLR033W RSC58
SGTC_2314 7727897 200 µM -0.94949436017013 0.164640818910568 no 2826 0.171184619539992 4042 900724
SGTC_2698 st077697 67.5 µM -0.953080248206019 0.163747401716314 no 2827 0.170274706459116 4013 3154499
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.953627305773325 0.163611380547294 no 2828 0.170136164422594 3998 688761
SGTC_960 1222-0186 7.7 µM -0.953901749750976 0.163543170049483 no 2829 0.170066688849069 4077 3126296
SGTC_1976 st070609 63.5 µM -0.954042954531702 0.163508082110619 no 2830 0.170030949902848 3940 682556
SGTC_3073 9114972 49.47 µM -0.954908168027534 0.163293192199099 no 2831 0.169812069394277 4041 41905075
SGTC_3194 9111903 49.47 µM -0.956509891888811 0.162895862384596 no 2832 0.169407344596651 4086 17087251
SGTC_2255 7941087 197.44 µM -0.956940692470444 0.162789103690894 no 2833 0.169298595309046 4133 935561
SGTC_2937 9044753 11.33 µM -0.957237462308208 0.162715586254714 no 2834 0.169223706190755 4002 6465530 YGL099W LSG1
SGTC_1116 jasmonic acid 1.58368 µM -0.957353882710782 0.162686751858752 no 2835 0.169194333605522 4107 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2056 5235370 200 µM -0.957949755486956 0.162539221253666 no 2836 0.169044047605769 3999 5511916
SGTC_439 amiodarone 34.4 µM -0.959289782057346 0.162207765636658 no 2837 0.168706390719135 3899 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1525 8-methoxypsoralen 92.5 µM -0.965459526320895 0.160687361244137 no 2838 0.167157349376663 4120 4114 Related to psoralen; DNA damaging agent.
SGTC_1469 k284-2957 126 µM -0.967058190575241 0.16029492699634 no 2839 0.166757472341607 4028 23884841
SGTC_1394 3474-0001 65.7 µM -0.968473526925058 0.15994801861256 no 2840 0.166403967009951 4034 5017666 YIL048W NEO1
SGTC_896 0964-0007 44.5 µM -0.969220828427411 0.159765048249853 no 2841 0.166217510548749 3997 6756758
SGTC_2100 5377183 190 µM -0.969523477831471 0.159690986114233 no 2842 0.166142036012269 4073 2844202
SGTC_44 0929-0055 61.211 µM -0.970232869403692 0.15951747708434 no 2843 0.165965215123594 3966 1379590
SGTC_1415 3966-0071 78.1 µM -0.972524541519928 0.158957803956591 no 2844 0.165394830922033 3985 2893185
SGTC_2333 9017922 200 µM -0.97268079094922 0.158919691569039 no 2845 0.165355987562763 4113 3163164
SGTC_921 1561-0023 372 µM -0.975288157143841 0.158284586183977 no 2846 0.16470867165269 4028 24050882
SGTC_423 5-fluorouracil 457 µM -0.975467538271115 0.158240953627903 no 2847 0.164664198164582 3997 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1889 st059080 5.18 µM -0.977527890707881 0.157740360763522 no 2848 0.164153938420425 3990 176925 Isolated from Daphnopsis sellowiana.
SGTC_1703 st026983 48.3 µM -0.977949883731544 0.157637959848795 no 2849 0.164049555759039 4088 1104023
SGTC_1313 1220-0047 237 µM -0.978282509251013 0.157557275657779 no 2850 0.163967309071916 4039 3528706
SGTC_3157 9099274 49.47 µM -0.980694113339544 0.156973110227499 no 2851 0.163371803834975 4089 17217662
SGTC_501 nsc-95397 161 µM -0.981498597695963 0.156778556455678 no 2852 0.163173462798097 4126 262093
SGTC_1815 st051655 58.2 µM -0.984388953273148 0.156080872442849 no 2853 0.162462153728233 4028 5984156
SGTC_1512 0259-0544 12.2 µM -0.984954691338558 0.155944552431778 no 2854 0.162323163538012 4038 18476
SGTC_1147 3809-1045 12.3 µM -0.986582653905913 0.155552717217599 no 2855 0.161923638642881 4044 325925
SGTC_2551 apiole 73.87 µM -0.987823193129144 0.155254567539513 no 2856 0.161619623327225 3945 10659 A possible DNA adduct former.
SGTC_547 1120-0019 610 nM -0.987939824349195 0.15522655594612 no 2857 0.161591060003128 4027 3676939
SGTC_2026 5148700 152 µM -0.989736811975621 0.154795390905686 no 2858 0.161151388504014 4047 79838
SGTC_1270 0831-1170 17.3 µM -0.991136737994327 0.154460044703324 no 2859 0.16080940803303 4071 6764716
SGTC_4 0960-0234 25.671 µM -0.992430578207653 0.154150538256381 no 2860 0.160493764335459 4086 6821112
SGTC_25 0118-0223 35.662 µM -0.993531639495508 0.153887470809606 no 2861 0.160225469763599 4064 5333628
SGTC_316 k060-0003 58.6 µM -0.993947760606272 0.153788127848219 no 2862 0.160124150301062 4108 6152314
SGTC_3164 9100705 49.47 µM -0.997477058232435 0.152947265681463 no 2863 0.159266502078339 4112 17174235
SGTC_1600 coumarin 106 71.1 µM -0.998856511933731 0.152619438202866 no 2864 0.158932102763517 4155 100336 A hepatotoxic, DNA x-linker.
SGTC_268 camptothecin 39.6153 µM -0.999095945499378 0.152562584276737 no 2865 0.15887410753706 4064 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_338 4055-0136 114 µM -1.00230601246251 0.151801705396632 no 2866 0.158097909787655 4044 2900563
SGTC_1988 st071872 53.4 µM -1.00246397436041 0.151764329055373 no 2867 0.158059778792189 4117 16414116
SGTC_2782 7736369 71.43 µM -1.00326975658542 0.151573763111568 no 2868 0.157865362050966 4132 2950836 YOL077C BRX1
SGTC_1937 st074714 47.2 µM -1.00346406418135 0.151527833553931 no 2869 0.157818503601782 4055 17250970
SGTC_2563 tomatine 8.54 µM -1.00426196029616 0.151339327466654 no 2870 0.157626181919164 3992 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_468 gf-109203x 121 µM -1.00524045190292 0.151108367983176 no 2871 0.157390540513195 4073 2396 A protein kinase C inhibitor.
SGTC_376 3970-0862 59.1 µM -1.00988442864055 0.150015420324644 no 2872 0.156275331883087 4142 3135186
SGTC_1851 st056236 18.9 µM -1.0104419192104 0.149884571632648 no 2873 0.156141806414417 4111 5393171
SGTC_1042 0350-0096 82 µM -1.01261780603842 0.149374597404814 no 2874 0.155621375714758 4078 3122515
SGTC_1460 k062-0059 9.15 µM -1.014479479134 0.148939187696603 no 2875 0.155177008215357 3990 1373085
SGTC_3321 9137793 26.8275 µM -1.01609441659724 0.148562172242993 no 2876 0.154792213806248 4075 4904192
SGTC_2534 helenine 20.12 µM -1.01704682200764 0.148340127682688 no 2877 0.154565577999972 4100 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_864 0469-0573 172 µM -1.01825450200151 0.148058887570334 no 2878 0.154278512195981 4090 689425
SGTC_1806 st050005 60.3 µM -1.01882559102824 0.147926018794356 no 2879 0.154142887068351 4149 5194765
SGTC_2739 tacrine 100.86 µM -1.01944617127754 0.14778172598247 no 2880 0.15399559795369 4155 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2037 5169046 200 µM -1.02226596774717 0.147127274730435 no 2881 0.153327517964366 4176 5718022
SGTC_2105 5350118 200 µM -1.02499256271195 0.146496305311379 no 2882 0.15268334846494 4096 2133313
SGTC_3007 9078383 71.4286 µM -1.02666324992053 0.146110585396087 no 2883 0.152289529883877 4110 6496995
SGTC_215 1287-0124 461.5 µM -1.0273482181524 0.145952640719011 no 2884 0.152128262535076 4142 5560863
SGTC_1251 0490-5699 265 µM -1.02836392561259 0.145718643185877 no 2885 0.151889335533925 4180 3883818
SGTC_441 propafenone 146 µM -1.02905286092025 0.145560070670345 no 2886 0.151727417804648 4107 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_307 1501-1223 22.3 µM -1.02962447608447 0.145428589890187 no 2887 0.151593160466059 4155 2830329
SGTC_746 1095-0025 46.6 µM -1.02969064403522 0.145413375346056 no 2888 0.151577624459412 4126 6749286
SGTC_2899 9053889 58.44 µM -1.0309233866323 0.145130116425127 no 2889 0.151288374299869 4111 6470052
SGTC_2737 bleomycin 30.5 nM -1.03131308904966 0.145040648118467 no 2890 0.151197011127196 4152 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_507 nimesulide 162 µM -1.03168703398116 0.144954832343103 no 2891 0.151109376708936 4186 4495 A COX2 inhibitor.
SGTC_550 4123-0385 25.7 µM -1.03362907197498 0.144509708240927 no 2892 0.150654801505982 4151 5731123
SGTC_1364 1653-0028 37.6 µM -1.03637996250557 0.143880769154071 no 2893 0.150012457316032 4117 5718652
SGTC_1140 3229-1848 2.98 µM -1.03768686513112 0.143582618556091 no 2894 0.149707930993025 4155 2849525
SGTC_1779 st039427 55 µM -1.0387204015323 0.143347127934835 no 2895 0.149467395014337 4078 1124498
SGTC_3337 9144342 33.5465 µM -1.04063106423498 0.142912471707018 no 2896 0.149023404104027 4126 17682949
SGTC_1308 1187-1617 41.4 µM -1.04632447189661 0.141622565404593 no 2897 0.147705625272997 4148 2882570
SGTC_476 mead acid 10 µM -1.04867364020893 0.141092640262576 no 2898 0.147164175131294 4173 5312531 An omega 9 fatty acid.
SGTC_2259 7964009 200 µM -1.04875397375477 0.14107454243845 no 2899 0.147145682942187 4182 313134
SGTC_2568 diosmetin 100 µM -1.04945124907284 0.14091752393265 no 2900 0.146985240756905 4203 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1142 3253-1408 9.78 µM -1.04946204705238 0.140915093282456 no 2901 0.146982757078037 4161 256655
SGTC_2834 9001755 58.44 µM -1.05025809827838 0.140735978640704 no 2902 0.146799732230693 4062 2989575
SGTC_1952 st077036 64.1 µM -1.05051611158292 0.140677957803295 no 2903 0.146740443687678 4163 2937007
SGTC_2735 sertaconazole 140 nM -1.05147694730378 0.14046203231844 no 2904 0.146519795821137 4275 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2693 st077581 40.7 µM -1.05397857735338 0.13990090514587 no 2905 0.145946362626622 4183 25238761
SGTC_1226 3909-7979 35.4 µM -1.05578500507965 0.13949666357666 no 2906 0.145533225225667 4139 6615510
SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.05629826701384 0.139381951133513 no 2907 0.145415983737706 4146 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1057 3448-5381 134 µM -1.05677528345417 0.139275396996827 no 2908 0.145307078574018 4136 5497911
SGTC_299 1273-0059 1.44 µM -1.05793791036173 0.139015925998136 no 2909 0.145041875118994 4006 2848077
SGTC_2533 agelasine 13.65 µM -1.05905805012722 0.138766248577991 no 2910 0.144786671627413 4219 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_346 4513-0042 7.16 µM -1.05925775557157 0.138721766643463 no 2911 0.144741204152278 4136 2827372
SGTC_3139 9095020 49.47 µM -1.06013186662793 0.138527183440445 no 2912 0.144542306106886 3853 25236292
SGTC_2975 9084847 53.72 µM -1.06070442814483 0.138399828116552 no 2913 0.144412123474691 4211 27211724
SGTC_697 0508-1955 564 µM -1.06075832300136 0.138387844350331 no 2914 0.14439987353531 4150 6243113
SGTC_1917 st066507 28.5 µM -1.06264029531776 0.137969822750591 no 2915 0.143972553006577 4115 3156428
SGTC_2057 5236571 38.335 µM -1.06407296073517 0.137652178659734 no 2916 0.143647824413459 4151 54684039 YBR257W POP4
SGTC_1650 st011916 45.8 µM -1.06418216090446 0.137627987780585 no 2917 0.143623093343466 4081 242528
SGTC_1572 epiandrosterone 68.9 µM -1.06668660109046 0.137073980834638 no 2918 0.143056689798057 4076 441302 A steroid.
SGTC_987 1497-1013 404 µM -1.06989948277806 0.136365493519686 no 2919 0.142332277971969 4164 1676435
SGTC_827 3253-0474 693 µM -1.07014100505675 0.136312335757426 no 2920 0.142277922160961 4212 5402065
SGTC_648 0375-0473 33.3 µM -1.07067436941928 0.136194995344108 no 2921 0.142157935574423 4142 1713139
SGTC_996 3970-0799 1.8 µM -1.07449583426367 0.135356293290699 no 2922 0.141300255416906 4180 6615648 YGL040C HEM2
SGTC_1372 2752-0194 270 µM -1.07824684344981 0.134536503656061 no 2923 0.140461806104374 4099 823334
SGTC_471 1-acyl-paf 4 µM -1.07932917688932 0.134300592709422 no 2924 0.140220505308505 4098 16759367
SGTC_2307 7538926 6.34 µM -1.08023236253223 0.134103947304232 no 2925 0.140019360249567 4144 96582
SGTC_775 4577-0580 57.3 µM -1.08276422416286 0.133553754496749 no 2926 0.139456544467799 4227 2006902
SGTC_370 0180-0345 38.7 µM -1.08840276992246 0.132334039595667 no 2927 0.138208669440015 4044 3989527
SGTC_3308 9128332 17.569 µM -1.08913057586246 0.132177163854432 no 2928 0.138048154104947 4185 17332805 YDL196W YDL196W
SGTC_525 k781-2675 26.7 µM -1.09114403466328 0.131743838807264 no 2929 0.137604754615794 4137 3651118 YDL195W SEC31
SGTC_2862 9027634 71.43 µM -1.09602479674978 0.130697500359107 no 2930 0.136533961507008 4139 5012562
SGTC_1669 st015249 58.4 µM -1.09696532575604 0.130496531649039 no 2931 0.136328274988659 4269 722793
SGTC_1108 betulinic acid 729.144 nM -1.09739916417112 0.130403902745552 no 2932 0.136233469322381 4180 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_407 eburnamonine 100 µM -1.09744438126481 0.130394251054922 no 2933 0.136223590736346 4029 3195
SGTC_1855 st056195 39.6 µM -1.09886485899009 0.130091298438604 no 2934 0.135913508289551 4137 4028379
SGTC_961 1252-1571 372 µM -1.09993451812653 0.12986348848002 no 2935 0.135680326828845 4212 6813498
SGTC_2046 4110841 106 µM -1.10056305797686 0.129729754523965 no 2936 0.1355434355256 4186 44119630 YMR134W ERG29
SGTC_2489 cantharidin 73.42 µM -1.10103343932577 0.12962973425177 no 2937 0.135441051896986 4145 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1320 1313-0481 95.3 µM -1.10206128095879 0.129411363457677 no 2938 0.135217515430103 4180 6813365 YLR208W SEC13
SGTC_955 1216-0110 33 µM -1.10227146841841 0.129366739349431 no 2939 0.135171834729345 4184 3619719
SGTC_1100 amiodarone 5.07 µM -1.10537334569257 0.128709431176761 no 2940 0.134498924198035 4284 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1520 flindersine 88 µM -1.10543215081056 0.128696992407846 no 2941 0.134486189470152 4267 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2931 9014674 55.67 µM -1.10634481667679 0.128504047429909 no 2942 0.134288650349209 4160 2996810
SGTC_3076 9116187 49.47 µM -1.11128305029097 0.127463547347093 no 2943 0.133223266421514 4186 27241210
SGTC_3350 9150499 3.57 µM -1.11156905974698 0.127403464334736 no 2944 0.13316174087968 4196 4910996 YPR165W RHO1
SGTC_2780 5215298 71.43 µM -1.11184868266654 0.127344742009637 no 2945 0.1331016080983 4233 2834131
SGTC_880 0833-0487 87.2 µM -1.11403319271121 0.126886631109181 no 2946 0.13263247355717 4202 76075
SGTC_571 k831-0106 44.2 µM -1.11429380551976 0.126832055013606 no 2947 0.132576581787858 4069 4783639
SGTC_1383 3049-0032 20.7 µM -1.11560494841939 0.126557730651825 no 2948 0.13229563651105 4272 712864
SGTC_717 1532-0246 73.2 µM -1.11740510372688 0.126181766148305 no 2949 0.131910576965703 4186 9561992
SGTC_3040 9091894 49.47 µM -1.11812153018381 0.126032356441643 no 2950 0.131757546097247 4061 25236966
SGTC_682 0kpi-0099 17 µM -1.11965377629979 0.125713222846958 no 2951 0.13143066493434 4230 1714895 YML126C ERG13
SGTC_923 1900-2434 73.3 µM -1.12029776855077 0.125579261648413 no 2952 0.13129344633097 4182 5910570
SGTC_813 k007-0158 173 µM -1.12103412547657 0.12542620914963 no 2953 0.131136668401059 4201 6523916
SGTC_349 k015-0014 24 µM -1.12205093976171 0.125215077417677 no 2954 0.130920390876144 4218 2196908
SGTC_1720 st037298 9.481 µM -1.12544250004391 0.12451264727375 no 2955 0.130200785047251 4209 597396
SGTC_2428 5615643 7.78 µM -1.12700967032126 0.12418900110223 no 2956 0.129869196197268 4241 2253075
SGTC_704 1310-0270 142 µM -1.12846125103956 0.123889751464176 no 2957 0.12956258629952 4236 5718033
SGTC_2831 7999036 19.48 µM -1.13689518760544 0.122161044501599 no 2958 0.127791052073993 4253 2988270
SGTC_2193 5925765 200 µM -1.13909286779382 0.121713380197013 no 2959 0.12733221098177 4224 877370
SGTC_400 oxethazaine 37.5 µM -1.14314940776432 0.120890099151306 no 2960 0.126488281774314 4233 4621 A local anesthetic.
SGTC_1081 sertraline 6 µM -1.14412564982154 0.120692555724964 no 2961 0.126285765824996 4228 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1115 galangin 695.678 nM -1.14637530146764 0.120238202254327 no 2962 0.125819948819108 4303 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_669 0108-0021 26.2 µM -1.1473067610857 0.120050432166253 no 2963 0.125627430340814 4186 17201
SGTC_1376 2910-0861 41.3 µM -1.14770203364579 0.11997081287359 no 2964 0.125545795687044 4160 1112859
SGTC_82 0054-0107 293.755 µM -1.15027997596083 0.119452453903067 no 2965 0.125014287714216 4196 3104697
SGTC_2926 9010726 65.15 µM -1.15060931302733 0.119386346556227 no 2966 0.124946499945736 4264 2994293
SGTC_1675 st018485 24.5 µM -1.15228187643893 0.119051013826071 no 2967 0.124602630959279 4270 3323024
SGTC_2688 kanamycin b 96.69 µM -1.15233637543515 0.119040098505089 no 2968 0.124591437433122 4281 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1701 st028638 40.4 µM -1.1524617581592 0.119014988933237 no 2969 0.124565687796523 4254 3490878
SGTC_526 4469-0568 170 µM -1.15394146723143 0.118718939824419 no 2970 0.124262083471339 4200 2901964
SGTC_2919 7978188 46.38 µM -1.15454990224124 0.118597359772247 no 2971 0.124137396043998 4262 2980291
SGTC_1128 3448-9350 235 µM -1.15708101362073 0.11809252679589 no 2972 0.123619631476644 4289 619386
SGTC_2595 hexamethylquercetagetin 100 µM -1.15983429452106 0.117545109787347 no 2973 0.123058139187832 4236 386331
SGTC_1651 st011928 86.1 µM -1.16067156786769 0.11737899693287 no 2974 0.122887744295236 4263 720198
SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.16084294462256 0.117345016736248 no 2975 0.122852887533547 4315 165506
SGTC_109 0132-0036 33.701 µM -1.16156649117288 0.11720163035534 no 2976 0.122705799958146 4056 67274 A color developer.
SGTC_1795 st049545 62.3 µM -1.16240007155105 0.117036592309413 no 2977 0.122536497122895 4205 5291882
SGTC_1350 1495-0454 146 µM -1.1635967883828 0.116799945999446 no 2978 0.122293726774924 4293 1069057
SGTC_1156 4092-0367 4.88 µM -1.16456915419148 0.116607914203482 no 2979 0.12209671786046 4278 1357585
SGTC_444 curcumin 90.4 µM -1.16501977886377 0.116518996636593 no 2980 0.12200549339014 4186 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2896 9052656 71.43 µM -1.17299208281075 0.114953842053896 no 2981 0.120399490310933 4047 6469436
SGTC_910 3454-3003 490 µM -1.17355679021643 0.114843546274866 no 2982 0.120286298621173 4171 820824
SGTC_1846 st056244 14.8 µM -1.17363146590131 0.114828966637527 no 2983 0.120271336011305 4277 5393182
SGTC_2010 4012422 159 µM -1.17543405167434 0.114477430278798 no 2984 0.11991055347978 4217 952393
SGTC_615 k087-0205 167 µM -1.17552607026862 0.114459505586611 no 2985 0.119892156703475 4267 9642773
SGTC_3322 9139058 2.11 µM -1.17616464957541 0.114335169055894 no 2986 0.119764543837825 4321 4908926 YPR165W RHO1
SGTC_1804 st050076 49.1 µM -1.1832841509372 0.112955454558253 no 2987 0.118348275964597 4295 3895976
SGTC_701 4424-0219 185 µM -1.18501616704809 0.112621605442595 no 2988 0.118005527407542 4312 2911779
SGTC_2916 7875993 68.79 µM -1.18601999873871 0.112428438014529 no 2989 0.117807200926134 4102 1299250
SGTC_2616 abietic acid 100 µM -1.18788650669266 0.112069895193357 no 2990 0.117439063218445 4317 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_270 tamoxifen 5.46 µM -1.18792127510468 0.112063224194203 no 2991 0.117432213463248 4331 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_3049 9092223 49.47 µM -1.19243096993599 0.111200356138468 no 2992 0.116546151411711 4257 8623917
SGTC_1172 0370-0043 85 µM -1.19353869023392 0.110989138770358 no 2993 0.116329234478762 4310 376585
SGTC_2103 5378138 10 µM -1.19663297680723 0.110400650742635 no 2994 0.115724820588519 4357 244142
SGTC_33 0986-0033 35.816 µM -1.20353904369399 0.109095294630484 no 2995 0.114383895943198 4252 2848082
SGTC_343 4130-2827 29.8 µM -1.20396847496971 0.109014493176115 no 2996 0.114300881746947 4281 1118244
SGTC_2717 st081029 62.2815 µM -1.20700948844059 0.1084435291012 no 2997 0.113714244930896 4265 5292846
SGTC_2946 9065502 71.43 µM -1.21193157211868 0.107523950589533 no 2998 0.1127692876852 4122 16489101
SGTC_916 4466-0038 42 nM -1.2131261811246 0.107301615209353 no 2999 0.112540790800725 4351 5722064 YGL116W CDC20
SGTC_2051 5263410 176 µM -1.2151581632954 0.106924193325145 no 3000 0.11215288676608 4269 227584
SGTC_2427 5545055 42.75 µM -1.22367751630726 0.105352227611333 no 3001 0.110536952300417 4235 5372858
SGTC_621 3584-0052 32.1 µM -1.22608977805986 0.104910176625169 no 3002 0.11008244604061 4328 2273927
SGTC_1513 0337-0559 19 µM -1.22732466495998 0.104684401910579 no 3003 0.109850294381481 4287 775073
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.22768182171446 0.104619168498438 no 3004 0.109783216514596 4356 6710655
SGTC_1828 st055811 49 µM -1.22842713888022 0.104483133811799 no 3005 0.109643332665506 4316 5877589
SGTC_1931 st074438 57.1 µM -1.22984934662289 0.104223909288376 no 3006 0.109376762687298 4311 2787313
SGTC_2208 7283366 200 µM -1.23158621846932 0.10390796392958 no 3007 0.109051845810413 4300 898663
SGTC_580 1123-0028 41 µM -1.23747045176089 0.102842757321162 no 3008 0.107956238787867 4360 1677248 YPR107C YTH1
SGTC_3162 9099653 49.47 µM -1.2389580198006 0.102574727876076 no 3009 0.10768052256839 4294 25237511
SGTC_2338 7999974 200 µM -1.24012559195949 0.102364711139484 no 3010 0.107464472247644 4312 315925
SGTC_3185 9108267 49.47 µM -1.24347465083113 0.101764035303197 no 3011 0.106846488226798 4330 4910486
SGTC_2468 5987765 72.9 µM -1.24806289389861 0.100945275192469 no 3012 0.106004012804339 4370 26772094
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.25177456832308 0.100286458547589 no 3013 0.105326009776676 4324 5024745
SGTC_1603 st002045 67.8 µM -1.25623431420142 0.0994990179046983 no 3014 0.104515514561715 4335 5887985
SGTC_1353 1498-1206 8.11 µM -1.25965212309002 0.0988986138249968 no 3015 0.103897441836736 4365 6756808
SGTC_3255 9139072 49.47 µM -1.26526034149957 0.0979191725259097 no 3016 0.102889009008298 4337 17646060
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.2656831493102 0.0978456209147918 no 3017 0.1028132717798 4413 4213774
SGTC_110 0850-0284 111.64 µM -1.2672679924746 0.097570282120475 no 3018 0.10252974060655 4172 3906265
SGTC_626 0214-0009 33 µM -1.27273378634832 0.096625055193307 no 3019 0.101556262090959 4400 3437874
SGTC_2977 9011197 71.43 µM -1.27381683040107 0.096438560141032 no 3020 0.101364169516501 4397 2704722
SGTC_1260 0700-1617 7.75 µM -1.27467112201063 0.0962916418723257 no 3021 0.101212836134797 4322 2853078
SGTC_3245 9134821 49.47 µM -1.27736624135424 0.0958292222884861 no 3022 0.100736488656359 4360 17014901
SGTC_3149 9097855 49.47 µM -1.28026920789673 0.0953329705090488 no 3023 0.10022523659349 4352 25236625 YMR079W SEC14
SGTC_181 1447-1644 8.07 µM -1.28279300053219 0.0949030767687625 no 3024 0.099782303505862 4327 534600
SGTC_3119 9125183 49.47 µM -1.2838981704984 0.0947152764076415 no 3025 0.0995887937417961 4191 22695334
SGTC_778 3456-2434 196 µM -1.28617449622678 0.094329326101134 no 3026 0.0991910848469055 4306 5539063
SGTC_1563 conessine 56.1 µM -1.28697149299355 0.0941944700584905 no 3027 0.099052112208056 4437 441082 An anti-amoebic, histamine inhibitor.
SGTC_2357 9067248 200 µM -1.28876749455423 0.0938910985926319 no 3028 0.0987394648960102 4313 9150235
SGTC_1775 st081588 35.1725 µM -1.29515121323308 0.092818630061665 no 3029 0.0976340354376738 4349 1426443 YGL099W LSG1
SGTC_1046 2001-0062 216 µM -1.29605602651529 0.0926673567913628 no 3030 0.0974780916316672 4293 739778
SGTC_1829 berberine 14.4 µM -1.2982976650344 0.0922933689770366 no 3031 0.0970925342297955 4322 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2382 9035899 200 µM -1.2999166843333 0.0920239525461743 no 3032 0.096814763047331 4353 6462679
SGTC_3244 9134489 49.47 µM -1.30275192368434 0.0915535519539723 no 3033 0.096329734449671 4380 16584271
SGTC_1924 st058459 75.1 µM -1.30348962199241 0.0914314515028972 no 3034 0.0962038285811285 4314 688683
SGTC_377 3970-0964 33.1 µM -1.3064199416795 0.0909476302653158 no 3035 0.0957048939780313 4344 16481235
SGTC_1529 apigenin 74 µM -1.3066339536228 0.0909123695970101 no 3036 0.0956685296985846 4382 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_365 0121-0052 13.6 µM -1.30861855201116 0.0905858695958967 no 3037 0.0953317967347128 4377 3101739
SGTC_345 1362-0200 395 µM -1.31000015934637 0.0903590862633389 no 3038 0.0950978908423202 4357 1419823
SGTC_2978 9011784 42.97 µM -1.3119648412222 0.0900373208685545 no 3039 0.0947659988338522 4361 2994934
SGTC_2424 5537928 59.2 µM -1.31855630043045 0.088964025330337 no 3040 0.0936587456323413 4380 5382802
SGTC_3195 9113082 49.47 µM -1.31952007767228 0.0888078937409244 no 3041 0.0934976511863092 4379 17018038
SGTC_1034 k072-0165 12.7 µM -1.31957015423342 0.0887997869344007 no 3042 0.0934892865331734 4398 5835461
SGTC_988 1497-1057 103 µM -1.31979021652109 0.0887641679686991 no 3043 0.0934525344758931 4362 3533044
SGTC_1249 0481-0015 10.2 µM -1.32350122709937 0.0881651106452226 no 3044 0.0928343742433089 4306 4227577
SGTC_687 k029-0044 34.9 µM -1.32512301146237 0.0879042592325102 no 3045 0.0925651774904591 4457 5829338
SGTC_2012 4023501 200 µM -1.32582296137316 0.0877918557098769 no 3046 0.0924491727635077 4380 3477460
SGTC_2178 5812956 200 µM -1.32645207825735 0.0876909186364441 no 3047 0.0923449992213097 4344 5403383
SGTC_3271 9137798 49.47 µM -1.32807409496679 0.0874310776650273 no 3048 0.0920768151880496 4360 6498326
SGTC_1240 0356-0016 42.1 µM -1.33056690184046 0.0870328603138078 no 3049 0.0916657796061315 4358 4305613
SGTC_2379 9035213 200 µM -1.3324207819139 0.0867375888296317 no 3050 0.0913609784213998 4380 646551
SGTC_412 gemfibrozil 100 µM -1.33267152989729 0.0866977091994384 no 3051 0.0913198100521643 4325 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_863 0466-0191 129 µM -1.33297630033096 0.0866492561456181 no 3052 0.0912697906740725 4436 765160 YPR165W RHO1
SGTC_3279 9140807 49.47 µM -1.33327764883682 0.0866013670196513 no 3053 0.0912203528833413 4433 45595718
SGTC_1561 5-methoxyflavone 52.9 µM -1.3344539632737 0.0864146210583187 no 3054 0.0910275624062144 4355 94525
SGTC_1901 st060216 58.6 µM -1.33679917896004 0.0860432048530903 no 3055 0.0906440986411624 4346 688792
SGTC_643 k048-0106 28.4 µM -1.3385635994946 0.0857645585531663 no 3056 0.0903563914038276 4415 6763920
SGTC_953 1188-0045 9.7 µM -1.33882591524117 0.0857231900538053 no 3057 0.0903136760444431 4388 6144426
SGTC_998 3996-0085 177 µM -1.33915451661043 0.0856713890608579 no 3058 0.0902601879313666 4413 715391
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.34003420058997 0.0855328302970893 no 3059 0.0901171131130528 4412 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2781 5567276 71.43 µM -1.34255296433949 0.0851370287641785 no 3060 0.0897083846931853 4407 2853274
SGTC_819 1013-0258 27.7 µM -1.34347302005259 0.0849927928781353 no 3061 0.089559428274299 4396 5753198
SGTC_2316 5844804 197.44 µM -1.34391231626965 0.084923989645552 no 3062 0.0894883714130137 4403 776813
SGTC_1552 6-methylflavone 10.6 µM -1.34766357728618 0.0843381612353124 no 3063 0.0888833059369563 4351 689013
SGTC_221 trifluoperazine 10.304 µM -1.34822684856036 0.0842504585656439 no 3064 0.0887927158602819 4385 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1477 0139-0234 16 µM -1.35086309149813 0.0838408989884049 no 3065 0.0883696465818451 4410 620880
SGTC_1449 4112-4002 201 µM -1.35128927644769 0.0837748286966253 no 3066 0.0883013928950541 4433 2059539
SGTC_1750 st081859 2.357 µM -1.35557600149105 0.0831124430330618 no 3067 0.0876170559016019 4325 5291695
SGTC_3018 9082602 49.47 µM -1.36035917417312 0.0823780039425154 no 3068 0.0868581455679317 4332 17332089
SGTC_2680 butyl paraben 22.24 µM -1.36200615406696 0.0821262503654499 no 3069 0.0865979714833657 4504 7184 An antifungal and steroid mimetic.
SGTC_822 1487-0950 154 µM -1.36290809568736 0.0819886274667298 no 3070 0.0864557384798278 4417 1958375
SGTC_3101 9120531 49.47 µM -1.37155015898984 0.0806787742892842 no 3071 0.0851017593087367 4407 24824904
SGTC_1332 1480-0653 17.5 µM -1.37680803923091 0.0798896210701668 no 3072 0.0842858023390138 4410 5749438
SGTC_3151 9099821 49.47 µM -1.38064389844811 0.079317591261455 no 3073 0.0836942393870376 4358 17174189
SGTC_2320 7373003 200 µM -1.38178585777151 0.0791478947533639 no 3074 0.083518731318363 4428 5415828
SGTC_1375 2910-0797 186 µM -1.38523475416221 0.0786370535543248 no 3075 0.0829903484720974 4409 742508
SGTC_1012 4112-3522 18 µM -1.38525532513722 0.0786340141516482 no 3076 0.082987204488495 4431 3112398
SGTC_3144 9087057 49.47 µM -1.38562188876881 0.0785798685702034 no 3077 0.0829311954247073 4340 17249618
SGTC_1384 3089-0840 101 µM -1.38914125298413 0.0780614560730272 no 3078 0.0823949007565125 4435 1069836
SGTC_2766 oltipraz 83.91 µM -1.39064440518634 0.0778408298256798 no 3079 0.0821666419351395 4394 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_513 4245-1575 41.7 µM -1.39617388807137 0.0770333072315052 no 3080 0.0813310689320977 4270 719745
SGTC_874 0599-0792 117 µM -1.39965289620077 0.0765285076909991 no 3081 0.0808086428344689 4429 765305
SGTC_2114 5491910 81.25 µM -1.40058734901498 0.0763933494489099 no 3082 0.0806687531064273 4471 2849228
SGTC_1891 st059073 26.2 µM -1.40186222432361 0.0762092458838467 no 3083 0.0804781964162918 4502 688754
SGTC_2619 obliquin 87.91 µM -1.40237597382126 0.0761351513251233 no 3084 0.080401502047932 4401 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2948 9070189 9.45 µM -1.40328180050604 0.0760046437641491 no 3085 0.080266411531324 4376 6473636 YDL196W YDL196W
SGTC_3224 9130643 49.47 µM -1.40342319416886 0.0759842877590468 no 3086 0.0802453402658445 4461 17644395
SGTC_2196 6573537 42.6665 µM -1.40547081778128 0.0756899629127052 no 3087 0.0799406605457972 4463 2903087
SGTC_373 0844-0104 25.9 µM -1.40818754517489 0.0753008028424784 no 3088 0.07953777163604 4454 5375804
SGTC_3293 9120939 62.045 µM -1.40828213056103 0.0752872814012253 no 3089 0.0795237724138317 4429 934087
SGTC_3253 9135987 49.47 µM -1.41022567758743 0.0750098514885128 no 3090 0.0792365280528001 4441 4182430
SGTC_599 1935-0052 86.5 µM -1.4121273331319 0.0747391566899545 no 3091 0.0789562359800417 4428 9557311
SGTC_872 0588-0139 234 µM -1.41215259911877 0.0747355651790137 no 3092 0.078952516994513 4412 2047100
SGTC_2145 5634607 200 µM -1.41272569633799 0.0746541358898628 no 3093 0.0788681965229964 4429 308662
SGTC_3292 9120825 59.784 µM -1.41612057566089 0.0741731578091365 no 3094 0.0783701024118909 4420 24824900
SGTC_1391 3442-0225 151 µM -1.42043532110491 0.0735652755606556 no 3095 0.0777404929719754 4422 5227075
SGTC_1174 0739-0097 51.1 µM -1.42228511392951 0.0733058373651287 no 3096 0.0774717492810916 4479 728447
SGTC_661 1304-0007 33.6 µM -1.428385993527 0.0724551328675726 no 3097 0.076590394204959 4465 3117130
SGTC_1431 4049-0260 9.09 µM -1.43117558735108 0.0720686816587775 no 3098 0.0761899491634123 4478 3854841
SGTC_715 0868-0130 184 µM -1.43144937776844 0.0720308379271677 no 3099 0.0761507326988771 4498 2876258
SGTC_2809 7964133 12.99 µM -1.43299422292065 0.071817592504297 no 3100 0.0759297441494029 4439 1253665
SGTC_617 3770-0098 35 µM -1.43752211807529 0.0711953655387982 no 3101 0.0752848463659352 4375 5962639
SGTC_2851 9015922 71.43 µM -1.43817652248824 0.0711057801405908 no 3102 0.0751919874154234 4470 2996893
SGTC_2770 toltrazuril 17.5 µM -1.44013924117174 0.070837610770181 no 3103 0.0749140044576483 4405 68591 Kills coccidiodes.
SGTC_3341 9147222 25.867 µM -1.44064639551886 0.0707684439525391 no 3104 0.074842302996058 4464 1939759
SGTC_2622 2-methoxyxanthone 59.94 µM -1.44154835120362 0.0706455614904221 no 3105 0.0747149139100398 4433 71034 A hepatoprotective.
SGTC_1611 st001856 99.4 µM -1.44158362654001 0.0706407589120256 no 3106 0.0747099351082851 4439 647478
SGTC_2755 lomerizine 42.69 µM -1.44736944181618 0.0698564367014238 no 3107 0.0738967397999014 4400 3949 A calcium channel blocker.
SGTC_3216 9129716 49.47 µM -1.44903772756047 0.0696315341022712 no 3108 0.0736635234272895 4382 8056934
SGTC_700 3453-2283 142 µM -1.45428526870927 0.0689277436105038 no 3109 0.0729336164643656 4494 565664
SGTC_2819 7996655 46.38 µM -1.46190050251767 0.067916171615551 no 3110 0.071884238634408 4439 6456960
SGTC_2415 st077333 57.7 µM -1.46334533961034 0.0677255466516595 no 3111 0.0716864536473236 4481 2766255
SGTC_73 0327-0325 16.231 µM -1.46481963824731 0.0675314609722968 no 3112 0.0714850662388186 4285 53298
SGTC_3190 9110366 49.47 µM -1.47793782784054 0.0658233798753646 no 3113 0.0697122100404874 4488 17123768
SGTC_460 trequinsin 123 µM -1.48015211580021 0.0655383962048331 no 3114 0.0694163280000175 4565 5537 A vasodilator.
SGTC_469 w7 172 µM -1.48255962507251 0.0652296311971982 no 3115 0.0690957254663932 4584 45115570 A P450 inhibitor.
SGTC_3251 9135047 49.47 µM -1.48510530085901 0.0649043751247139 no 3116 0.0687579660585453 4533 17682963
SGTC_10 0279-0212 42.575 µM -1.48699262321289 0.0646640494072594 no 3117 0.0685083796338206 4493 39851 YBR002C RER2
SGTC_1771 st048882 4.1505 µM -1.48762891123398 0.0645831824471327 no 3118 0.0684243922871803 4517 4580403
SGTC_2190 6049624 200 µM -1.48985811672344 0.0643004884004199 no 3119 0.0681307731100936 4384 2265554
SGTC_577 r071-0003 38.6 µM -1.49015278081367 0.0642631929931631 no 3120 0.0680920343991488 4447 4568517 YMR134W ERG29
SGTC_311 1315-0136 58 µM -1.49098475872078 0.0641579809365683 no 3121 0.0679827482395145 4512 6759207
SGTC_2277 7947813 106.88 µM -1.49198800958758 0.064031287817041 no 3122 0.0678511443499747 4503 1246798
SGTC_2786 7743617 45.45 µM -1.49198891316055 0.0640311737992455 no 3123 0.0678510259103245 4428 583674
SGTC_1769 st044406 64.4 µM -1.50365999990423 0.0625715767231644 no 3124 0.0663344667814879 4472 670903
SGTC_1727 st034309 9.9045 µM -1.50404597849774 0.0625237526673061 no 3125 0.0662847642196035 4511 870305
SGTC_2605 digitonin 300 nM -1.50432265838585 0.0624894886297359 no 3126 0.0662491538299942 4503 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_720 r052-1644 49.9 µM -1.50737292347606 0.0621127134699217 no 3127 0.0658575475473234 4504 1422863 YOR257W CDC31
SGTC_1200 1643-0193 18.4 µM -1.51040193880362 0.061740319328763 no 3128 0.0654704471104201 4516 5403974
SGTC_3324 9138759 60.749 µM -1.51209208754414 0.0615332874740153 no 3129 0.0652552187365626 4519 45595710
SGTC_1315 1237-0019 3.69 µM -1.51976284921919 0.0606004777812482 no 3130 0.0642852946572921 4501 825140
SGTC_2341 7987486 176.74 µM -1.52326615382787 0.0601781519634428 no 3131 0.0638460656533978 4518 1258686
SGTC_302 1094-0063 18.9 µM -1.52499217175668 0.0599709282868088 no 3132 0.0636305251079746 4492 5440289
SGTC_711 k292-0785 179 µM -1.52804634182181 0.0596056180112195 no 3133 0.0632505162232114 4458 4146315
SGTC_1248 0469-0687 58.6 µM -1.53217694392332 0.0591143321890003 no 3134 0.0627393882155366 4471 4017482
SGTC_1940 st075990 51.1 µM -1.53416308697209 0.0588792376917412 no 3135 0.0624947681115258 4554 1084979
SGTC_2959 9079155 11 µM -1.53677117685832 0.0585716399488685 no 3136 0.0621746770306527 4523 16189457
SGTC_1217 1183-1422 255 µM -1.53826738510327 0.0583957477009674 no 3137 0.0619916254134396 4547 2849664
SGTC_2243 6634756 200 µM -1.53848848181325 0.0583697910825801 no 3138 0.0619646113298613 4545 885676
SGTC_535 2293-4129 48.2 µM -1.54196744112866 0.0579625553602927 no 3139 0.0615407528807979 4507 396118 YIL048W NEO1
SGTC_1325 1431-0015 227 µM -1.54220627396607 0.0579346804814729 no 3140 0.0615117379830331 4509 1103340
SGTC_1545 lovastatin 49.4 µM -1.54550418059434 0.0575508485124638 no 3141 0.0611121792369351 4543 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_3250 9135583 49.47 µM -1.54622115463946 0.0574676676608066 no 3142 0.0610255830794558 4533 7699353
SGTC_1009 4106-0057 9.87 µM -1.54670714739648 0.0574113382622623 no 3143 0.0609669394167895 4519 2928005
SGTC_2833 9001315 45.46 µM -1.5497992951078 0.0570539571026884 no 3144 0.0605948481423834 4469 2989378
SGTC_646 4092-0839 27.3 µM -1.55877669637199 0.0560262941973102 no 3145 0.0595246208130514 4540 877796
SGTC_2033 5192550 145 µM -1.56009456672503 0.0558766713122138 no 3146 0.0593687676705358 4529 182073
SGTC_9 0092-0002 10.449 µM -1.56089740548361 0.0557856765721538 no 3147 0.0592739797918598 4529 759368
SGTC_1810 st050138 53 µM -1.56303454943845 0.055544019880556 no 3148 0.0590222343313948 4531 3444541
SGTC_2064 5220758 200 µM -1.56560049268295 0.0552549694298059 no 3149 0.0587210872954199 4551 788518
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.56705468401926 0.0550916847147766 no 3150 0.0585509550956859 4601 688801
SGTC_24 0417-1663 219 µM -1.56730454748881 0.0550636670677601 no 3151 0.0585217614771102 4542 4329390
SGTC_2711 st079103 59.1 µM -1.56800287392841 0.0549854221461323 no 3152 0.0584402308216607 4463 54693780
SGTC_1452 4194-0072 190 µM -1.57335847978528 0.0543882632040135 no 3153 0.0578179176603904 4580 1343545
SGTC_1181 1222-0449 220 µM -1.57545728431229 0.0541556468909435 no 3154 0.0575754653973782 4562 658318
SGTC_2036 5160441 105 µM -1.57994292169498 0.0536611311326789 no 3155 0.057059969272384 4511 134534 YIL048W NEO1
SGTC_1569 carminic acid 40.6 µM -1.58372510830412 0.0532469521236028 no 3156 0.0566281442238157 4601 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2239 6685329 187.64 µM -1.58556005418878 0.053046926203497 no 3157 0.0564195718926707 4547 805680
SGTC_2050 5263056 171 µM -1.58699502815971 0.0528909164565127 no 3158 0.0562568853387576 4517 763468 YGL055W OLE1
SGTC_1361 1608-0041 5.61 µM -1.59019945044146 0.05254384686083 no 3159 0.0558949271798103 4545 X1361
SGTC_3042 9091578 49.47 µM -1.59128931698559 0.0524262166927746 no 3160 0.0557722399553058 4530 25236497
SGTC_1125 tnp00248 1.32998 µM -1.59475941165871 0.0520530786284534 no 3161 0.0553830233239533 4567 24207736
SGTC_2750 bromebric acid 70.15 µM -1.5952121936448 0.0520045471326849 no 3162 0.0553323964587953 4535 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2801 7907800 81.82 µM -1.59796923982179 0.0517098082288844 no 3163 0.0550249115038837 4526 6620925
SGTC_2150 5556613 200 µM -1.59878846723129 0.051622486018999 no 3164 0.0549338062254981 4576 743190
SGTC_2015 5119600 184 µM -1.6077181627969 0.0506782467681587 no 3165 0.0539484594155777 4531 2828786
SGTC_2204 7233102 200 µM -1.60784197683427 0.0506652518291726 no 3166 0.0539348961668881 4546 2172480
SGTC_893 0958-0369 48.9 µM -1.61264985148655 0.0501626891116198 no 3167 0.0534103006853845 4418 6819948
SGTC_1160 4092-0570 10.5 µM -1.61360765410503 0.0500630471777224 no 3168 0.0533062777857975 4564 4994975
SGTC_2982 9019404 25.97 µM -1.61520150458115 0.0498975859086703 no 3169 0.0531335324237217 4501 22333232
SGTC_3052 9092717 49.47 µM -1.62005422220502 0.0493964984783331 no 3170 0.0526103149158031 4549 25237534
SGTC_532 1548-0774 215 µM -1.62219658685841 0.0491765617897878 no 3171 0.0523806311421496 4615 5932993
SGTC_799 1310-0557 151 µM -1.62265019064018 0.0491300949751898 no 3172 0.0523321023757269 4570 5354492
SGTC_372 0155-0182 15.9 µM -1.62283902256608 0.0491107615221433 no 3173 0.05231191073328 4443 771486
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.62390390436407 0.0490018479184925 no 3174 0.0521981595825541 4531 521171
SGTC_3075 9116269 49.47 µM -1.6397981489738 0.0473990465764718 no 3175 0.0505235716014565 4567 17015205 YNL244C SUI1
SGTC_2798 7813637 45.45 µM -1.64092140532366 0.0472873837785837 no 3176 0.0504068655191043 4553 956368
SGTC_1317 1273-0028 910 nM -1.64467592281438 0.046915676905557 no 3177 0.0500183303086989 4584 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1073 triclabendazole 3.09 µM -1.6466375081166 0.0467224089468345 no 3178 0.0498162880289785 4608 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_886 0866-0150 153 µM -1.6555637729475 0.0458509890581702 no 3179 0.0489050958315222 4589 271463
SGTC_2888 9058547 12.99 µM -1.66615325449138 0.0448341888298338 no 3180 0.0478414469021762 4504 16476514
SGTC_2487 5918373 44.05 µM -1.66910906413974 0.0445536368322976 no 3181 0.0475478836405045 4617 2876279
SGTC_2004 4023728 41.89 µM -1.69356476420197 0.0422862994334021 no 3182 0.0451740092089574 4536 360084 YDR527W RBA50
SGTC_1130 3454-2858 15.9 µM -1.69437293400215 0.0422129961622788 no 3183 0.0450972196659613 4541 715628 YIL048W NEO1
SGTC_2529 gangaleoidin 93.61 µM -1.71004437948094 0.0408117710243342 no 3184 0.0436288333913781 4568 4565183
SGTC_1149 3909-7961 23.3 µM -1.71357821404019 0.0405010738192428 no 3185 0.0433031087548849 4639 735261
SGTC_2641 levomentholum 100 µM -1.71398767617944 0.0404651980923849 no 3186 0.0432654946190862 4605 16666
SGTC_3091 9116372 49.47 µM -1.72175115695077 0.0397898562833763 no 3187 0.0425573029571757 4625 17169793
SGTC_1196 1588-0294 184 µM -1.72220061141721 0.0397510407258561 no 3188 0.0425165920697492 4628 6144269
SGTC_1634 st006576 41 µM -1.74003676035484 0.0382353687344549 no 3189 0.0409262816673141 4580 3915356
SGTC_1448 4255-0083 152 µM -1.74100139834736 0.0381547582428501 no 3190 0.040841666705349 4632 5399660
SGTC_2519 cryptotanshinone 88.04 µM -1.74246149367233 0.0380330083158939 no 3191 0.0407138618623867 4617 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2651 TUB2.036 5 µM -1.7431229101115 0.0379779605559794 no 3192 0.0406560737648335 4482 15992207 YFL037W TUB2
SGTC_2044 5102272 200 µM -1.74457890859198 0.0378570110824162 no 3193 0.0405290974165423 4614 592666
SGTC_836 0330-0104 1.35 µM -1.74617422551199 0.0377248495378594 no 3194 0.040390341041919 4643 46494820
SGTC_2804 7954240 19.48 µM -1.7468367808139 0.0376700719750073 no 3195 0.0403328272489386 4602 828705
SGTC_1293 1000-1278 195 µM -1.75376614087207 0.0371010604910396 no 3196 0.0397352935168588 4627 678847
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.75495624187562 0.037004044579053 no 3197 0.0396333964195689 4604 688803
SGTC_1467 k284-1082 293 µM -1.75720366561715 0.0368214023033196 no 3198 0.0394415503482154 4583 3334705
SGTC_454 lyso-paf C-16 6.67 µM -1.75798673539706 0.0367579376929451 no 3199 0.0393748831609766 4609 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2248 tofa 1.1 µM -1.76416794836162 0.0362601096966776 no 3200 0.0388518536368872 4645 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_858 0438-0351 2.77 µM -1.76727413221048 0.0360120326706079 no 3201 0.0385911649002778 4607 2799119
SGTC_1084 voriconazole 435 nM -1.7675368023831 0.0359911182796211 no 3202 0.0385691856337456 4638 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1844 rapamycin 4 nM -1.76754547926405 0.0359904275765949 no 3203 0.0385684597585964 4458 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1641 st009299 47.1 µM -1.7700835937414 0.0357888524400125 no 3204 0.0383566080889084 4555 4046054
SGTC_2954 9074818 52.69 µM -1.77024634427196 0.0357759585409921 no 3205 0.0383430560365497 4602 16648742
SGTC_2556 citropten 84.59 µM -1.77443590977443 0.0354453486327813 no 3206 0.037995537221928 4589 2775 A potential DNA crosslinker.
SGTC_2667 digitoxin 100 µM -1.78344102874272 0.0347432067636679 no 3207 0.0372572697324201 4604 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1735 st034310 56.75 µM -1.78388308357204 0.0347090353320988 no 3208 0.0372213326304857 4619 871153
SGTC_332 4112-0506 40.9 µM -1.78694748825938 0.0344729108449917 no 3209 0.0369729880916682 4623 2790355
SGTC_303 1348-1668 34.2 µM -1.78729783224991 0.0344459997234258 no 3210 0.0369446821063246 4647 5380509
SGTC_890 0929-0006 47.2 µM -1.79391415589724 0.0339410101234909 no 3211 0.0364134358186126 4627 1378169
SGTC_932 2857-0803 154 µM -1.79702679765363 0.0337055531613721 no 3212 0.0361656828062652 4611 674898
SGTC_1331 1472-0049 76.2 µM -1.79719008995235 0.0336932380527642 no 3213 0.0361527236326011 4614 24051409
SGTC_1369 1866-0067 208 µM -1.79784859888551 0.0336436124767781 no 3214 0.0361005017456455 4628 3531355
SGTC_395 anisomycin 6.25 µM -1.81209406851428 0.0325847102020928 no 3215 0.0349858313676243 4638 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2772 vinpocetine 57.06 µM -1.81826614371721 0.032134536619211 no 3216 0.0345117323970876 4620 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1234 0326-0494 15.5 µM -1.81896285823615 0.0320840443050273 no 3217 0.0344585483809169 4676 1547813
SGTC_192 3455-0609 60.9 µM -1.8294534860603 0.0313316539928795 no 3218 0.0336658506618902 4682 3769639
SGTC_2670 beta-carotene 100 µM -1.83095134965879 0.0312254268316492 no 3219 0.0335539024528056 4643 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1884 5633444 25 µM -1.83494002128967 0.0309440058013826 no 3220 0.0332572884564469 4581 5724239
SGTC_3131 9127911 49.47 µM -1.84038175418518 0.0305634523616727 no 3221 0.0328561051418077 4625 45595681
SGTC_297 0986-0032 24 µM -1.84651861218997 0.0301389462731777 no 3222 0.0324084697220834 4621 2847425
SGTC_2774 tamoxifen 10.92 µM -1.85603423543117 0.0294903938864871 no 3223 0.031724339211772 4630 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1797 st048695 56.8 µM -1.86123871172149 0.0291406034332644 no 3224 0.0313552369175011 4617 592262 YIL048W NEO1
SGTC_3314 9135860 59.4275 µM -1.86582566156 0.0288351808220197 no 3225 0.0310328804135527 4633 25252478
SGTC_166 k072-0058 166.424 µM -1.87029202456007 0.0285403493124577 no 3226 0.0307216382327709 4526 5846229
SGTC_2874 9043904 71.43 µM -1.87760545360875 0.0280629956589477 no 3227 0.0302175795684312 4575 4463428
SGTC_598 3937-0236 20.2 µM -1.87886677695613 0.0279813439971176 no 3228 0.0301313431215053 4695 1379313
SGTC_195 4234-0266 16.654 µM -1.88626666622437 0.0275062888533545 no 3229 0.029629514406652 4676 2303354
SGTC_2369 9071472 200 µM -1.8870848950258 0.0274541758372127 no 3230 0.0295744540050584 4666 17296037
SGTC_3270 9137563 49.47 µM -1.89248674507109 0.0271121938534368 no 3231 0.0292130790250279 4653 17015724
SGTC_1011 4112-3381 17.4 µM -1.89656494509384 0.0268563710673767 no 3232 0.0289426904283005 4677 2877139
SGTC_1307 1187-1599 12.2 µM -1.90056945242905 0.0266071351668216 no 3233 0.0286792149393806 4679 1538471
SGTC_654 1124-0271 80.9 µM -1.91270174473023 0.0258638024614766 no 3234 0.0278931228577724 4669 5403748
SGTC_512 prima-1 270 µM -1.9134960962624 0.0258157455883212 no 3235 0.0278422863935913 4661 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1868 st057644 42.7 µM -1.9155006871123 0.0256948034883565 no 3236 0.0277143408002941 4678 688665
SGTC_2376 9072922 81.32 µM -1.92453503195789 0.0251556082681701 no 3237 0.027143776997377 4652 17087968
SGTC_438 sphingosine 6.67 µM -1.92841089852896 0.0249272096178357 no 3238 0.0269020186484773 4623 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2080 5212524 12.4 µM -1.93322100122342 0.0246461784428376 no 3239 0.0266044893525986 4631 260183
SGTC_3238 9133470 49.47 µM -1.93890551697473 0.0243174915376569 no 3240 0.0262564220295725 4684 3534688
SGTC_158 k038-0087 26.446 µM -1.94153871949123 0.0241664879066122 no 3241 0.026096483843634 4592 X158
SGTC_2933 9026794 32.47 µM -1.94477307033552 0.0239820894485728 no 3242 0.0259011483068748 4609 17586027
SGTC_2918 7977171 22.06 µM -1.94519344615548 0.0239582098187902 no 3243 0.0258758501720557 4654 2236483
SGTC_2768 sulfasalazine 50.2 µM -1.9552183039562 0.023394636470016 no 3244 0.0252786545138862 4655 5384001 An antioxidant and salicylic acid derivative.
SGTC_32 0928-0142 34.1 µM -1.95797538614438 0.0232416102954215 no 3245 0.0251164504855689 4684 2244242
SGTC_1859 st055998 20 µM -1.96320821334056 0.0229534896916356 no 3246 0.0248109926984186 4629 676301
SGTC_124 0136-0217 7.121 µM -1.97104429977119 0.0225276628005555 no 3247 0.0243594044711706 4713 3976905
SGTC_1908 st060353 56.5 µM -1.97351563764326 0.0223947553206829 no 3248 0.0242184223620972 4664 4227716
SGTC_3152 9099253 49.47 µM -1.97551934449941 0.0222874828839193 no 3249 0.0241046207756138 4526 25236131
SGTC_3328 9140624 29.0385 µM -1.98015510464943 0.0220409589597212 no 3250 0.0238430514129848 4672 4904392
SGTC_3174 9107204 49.47 µM -1.98789022249989 0.0216347405984241 no 3251 0.0234119161736787 4677 3938802
SGTC_2598 perillyl alcohol 100 µM -1.98790506382119 0.0216339673119006 no 3252 0.0234110953047109 4669 10819 An apoptosis inducer.
SGTC_17 0960-0276 49.807 µM -1.99486787543574 0.0212737461705094 no 3253 0.0230286460178641 4681 6821114
SGTC_1887 st057648 70.8 µM -2.00461825911135 0.0207778448558601 no 3254 0.0225019365546142 4689 688672
SGTC_2217 6934799 96.0675 µM -2.00777973760998 0.0206191691813549 no 3255 0.0223333514671479 4672 675606
SGTC_594 1487-1584 10.8 µM -2.00880085987689 0.0205681385127011 no 3256 0.0222791285199072 4673 5013332
SGTC_581 0958-0271 211 µM -2.01654022566041 0.0201848308094674 no 3257 0.0218717581598976 4695 4591145
SGTC_1404 3909-7820 48.3 µM -2.01928238585498 0.0200504810223004 no 3258 0.0217289387889979 4675 23741373
SGTC_2793 7325131 81.82 µM -2.02013542148981 0.0200088422644507 no 3259 0.0216846712853957 4648 4176441
SGTC_1994 st072947 40.9 µM -2.02687983429235 0.0196822065091 no 3260 0.0213373516553558 4707 5286565 YDL195W SEC31
SGTC_2582 agaric acid 100 µM -2.03236426632014 0.0194199402860661 no 3261 0.0210583964094599 4375 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2958 9077254 16.72 µM -2.0502607749594 0.0185846838271499 no 3262 0.0201694950695613 4689 16457351
SGTC_2220 6782180 200 µM -2.05155984485474 0.0185252633304243 no 3263 0.0201062290123173 4690 833803
SGTC_2687 chenodiol 100 µM -2.0614205720267 0.0180794783063459 no 3264 0.0196314669509072 4708 5702181 A cholesterol synthesis inhibitor.
SGTC_1687 st020778 55.3625 µM -2.06144870522762 0.0180782196559573 no 3265 0.0196301261656053 4729 4259299
SGTC_1663 st014140 55.4 µM -2.07156022947574 0.0176306521905682 no 3266 0.0191532360449226 4741 4207120
SGTC_380 3970-0968 6 µM -2.08123321254662 0.0172113807994403 no 3267 0.0187062824685809 4647 2891601
SGTC_847 0342-0274 5.54 µM -2.08707761358358 0.0169622092661404 no 3268 0.0184405596508452 4702 18097
SGTC_1628 st004252 77.7 µM -2.10114857443877 0.0163749249093768 no 3269 0.0178139630162722 4695 692968
SGTC_762 1165-0429 115 µM -2.10616951756312 0.0161696217214694 no 3270 0.0175948149852195 4714 5967793
SGTC_1909 st060837 51.5 µM -2.11801871361639 0.0156938413975221 no 3271 0.0170867414265341 4659 678937
SGTC_2130 NSC 7 2.4545 µM -2.11887142091398 0.01566007076105 no 3272 0.0170506673983735 4714 21448
SGTC_1689 st020265 53.493 µM -2.12000783500983 0.0156151611238211 no 3273 0.0170026922785141 4711 5758320 YPR016C TIF6
SGTC_859 0439-0102 54.6 µM -2.1281423028039 0.0152969125492393 no 3274 0.01666264342459 4726 610143
SGTC_3192 9110362 49.47 µM -2.12886380393453 0.0152689557976069 no 3275 0.0166327651126348 4692 16649480
SGTC_2466 5983409 37.09 µM -2.13136539548633 0.0151723636390174 no 3276 0.016529525697035 4720 2879657
SGTC_2571 chrysanthemic acid 100 µM -2.14332421302242 0.014717827103818 no 3277 0.0160435369460302 4689 2743 An insecticide.
SGTC_3014 9081533 49.47 µM -2.1497782652894 0.0144774211945058 no 3278 0.0157863790987452 4714 21367265
SGTC_994 3910-0338 138 µM -2.15337858642774 0.0143447880060531 no 3279 0.0156444685541836 4723 3479481
SGTC_2305 7443522 69.23 µM -2.16728357563078 0.0138423168984662 no 3280 0.0151066190392739 4653 5415886
SGTC_3218 9131285 49.47 µM -2.1791431189821 0.0134258264438301 no 3281 0.0146605189572881 4674 17156417
SGTC_1647 st011722 22.4 µM -2.18781159161971 0.0131282879457977 no 3282 0.0143416645898699 4727 2854783
SGTC_2191 5911152 200 µM -2.18938257636598 0.0130749795133862 no 3283 0.0142845224876313 4729 2875902
SGTC_2438 5259590 200 µM -2.1907003764028 0.013030406831151 no 3284 0.0142367409227213 4734 1201127
SGTC_790 1575-0012 79.1 µM -2.20074894940965 0.0126948275013897 no 3285 0.013876900717046 4723 378741 YLR208W SEC13
SGTC_201 4262-0159 12.803 µM -2.20955357656801 0.0124069638430778 no 3286 0.0135680801025116 4756 1341029
SGTC_1048 3161-0300 24.5 µM -2.22730019650545 0.0118438868317182 no 3287 0.0129636087069135 4722 2165101
SGTC_2402 5553605 200 µM -2.23212762396722 0.0116946084023595 no 3288 0.0128032645877222 4722 6758546
SGTC_2269 7935389 174.42 µM -2.25172268630039 0.0111053164552662 no 3289 0.0121699010479681 4725 97605
SGTC_470 aa-861 153 µM -2.2693713662535 0.0105968362738872 no 3290 0.0116228759704879 4698 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1726 st035556 14.5795 µM -2.27110755271607 0.0105479278456407 no 3291 0.0115702339491481 4727 5919439
SGTC_1867 st057372 64 µM -2.28618321764786 0.0101314497870875 no 3292 0.011121771075674 4732 688837
SGTC_2439 5492030 7.2 µM -2.30049314114001 0.00974947240282971 no 3293 0.0107101487136832 4737 5722370
SGTC_3342 9147791 14.508 µM -2.31312533139311 0.00942279557283011 no 3294 0.0103578746758657 4718 1838168
SGTC_3019 9081971 49.47 µM -2.31512960780919 0.00937185341623804 no 3295 0.0103029200638832 4729 16451803
SGTC_849 0386-0493 241 µM -2.32550003654025 0.00911210100987149 no 3296 0.0100226189820338 4743 726119
SGTC_2639 lactacystin 53 µM -2.34129332274966 0.00872862912683032 no 3297 0.00960853126341 4740 3870 A proteasome inhibitor.
SGTC_1888 azatryptophan 97.5 µM -2.3653152627818 0.00817248410951833 no 3298 0.00900736419154805 4749 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2983 9022671 12.99 µM -2.36676559662971 0.00813992612961808 no 3299 0.00897214689781652 4738 6405161
SGTC_2648 atorvastatin 78.68 µM -2.37034166510842 0.00806013488015458 no 3300 0.00888582700685865 4754 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2017 5132927 60.65 µM -2.38672923587788 0.00770321563869677 no 3301 0.00849950293462192 4716 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_3126 9127922 49.47 µM -2.39047297461165 0.00762365671567536 no 3302 0.0084133437432855 4700 45595682
SGTC_2372 9071633 200 µM -2.40398812471918 0.00734243167503543 no 3303 0.00810865004510277 4767 21321366
SGTC_2499 avocadenofuran 51.48 µM -2.41046769446148 0.00721087670561725 no 3304 0.00796604111356417 4724 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2584 androsterone 48.74 µM -2.41860197304065 0.0070486718799002 no 3305 0.00779013896162104 4677 2754130 A steroid.
SGTC_2422 chlorphenesin carbamate 384.24 µM -2.43352792897764 0.00675939338809033 no 3306 0.00747624091799225 4705 2724 A muscle relaxant with antifungal properties.
SGTC_1788 fluconazole 20 µM -2.45298055203386 0.0063981547155017 no 3307 0.0070838999112585 4747 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_65 0798-0905 34.986 µM -2.46505905916549 0.00618254984792561 no 3308 0.00684953348273954 4714 3602145
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -2.52433427607741 0.00521507133265323 no 3309 0.00579588227396953 4751 688798
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -2.53401914773643 0.00507049591033238 no 3310 0.00563812849409398 4730 279621
SGTC_184 1494-0393 24.714 µM -2.54598716651222 0.00489677432186674 no 3311 0.00544845972090273 4742 3090647
SGTC_3168 9103419 49.47 µM -2.55434050014785 0.00477868483071003 no 3312 0.00531945801158831 4782 16649256
SGTC_115 0527-0192 112.043 µM -2.56619695046825 0.00461543265675499 no 3313 0.00514102141089263 4737 4233931
SGTC_1622 st003707 19.4 µM -2.58841712920971 0.00432283298712191 no 3314 0.00482090719421731 4771 10140899
SGTC_2879 9041815 71.43 µM -2.60607957360991 0.00410219934364959 no 3315 0.00457925909581786 4780 4942971
SGTC_1807 st050092 58.9 µM -2.6073133354743 0.00408717090753832 no 3316 0.00456279055673587 4768 5008496
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -2.62239118677666 0.0039074485231975 no 3317 0.00436575726023439 4772 1241132 A phosphatase inhibitor.
SGTC_690 glyoxal 20.3 µM -2.63321632321717 0.00378281767677389 no 3318 0.00422902288596705 4651 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_3087 9117406 49.47 µM -2.63465088794602 0.00376657167147952 no 3319 0.00421119300752988 4760 42546093
SGTC_891 0929-0073 133 µM -2.64594569193101 0.00364083122775429 no 3320 0.00407314468998826 4790 5603632
SGTC_852 0418-0143 439 µM -2.66897355103681 0.00339607431949264 no 3321 0.00380417206479578 4758 5369229
SGTC_2175 5807670 165.306 µM -2.67648847155401 0.00331946152045298 no 3322 0.00371990626224004 4765 241186
SGTC_3100 9120536 49.47 µM -2.71285637896317 0.00297021500795991 no 3323 0.00333530053179818 4737 16421196
SGTC_1465 k213-0056 144 µM -2.74531488641428 0.00268686034731937 no 3324 0.00302264309211844 4739 24048857 YMR208W ERG12
SGTC_2608 thymoquinone 42.66 µM -2.7698863455861 0.00248884731013713 no 3325 0.00280379280576536 4749 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2955 9076254 12.21 µM -2.77026192098124 0.00248592585613839 no 3326 0.00280056156761808 4763 16459619
SGTC_121 0557-0495 61.343 µM -2.79256344889101 0.00231791168373943 no 3327 0.00261461055507292 4767 3104427
SGTC_119 0121-0043 24.815 µM -2.80518545188874 0.00222744340335262 no 3328 0.00251438185514656 4780 1092378
SGTC_308 4092-1169 104 µM -2.81069244850965 0.00218898419177548 no 3329 0.00247175074517117 4768 2268590 YDL196W YDL196W
SGTC_2383 9036125 200 µM -2.83198526731106 0.00204587941496481 no 3330 0.00231299900261357 4780 79580
SGTC_3124 9127567 49.47 µM -2.88156831026755 0.00174497600193442 no 3331 0.0019785072588693 4770 17592030
SGTC_1540 guanosine 70.6 µM -2.90028686067077 0.00164227415606455 no 3332 0.0018641064630187 4783 6802 Guanosine is a purine nucleoside
SGTC_2848 9016370 25.97 µM -2.91496231778328 0.00156563996339016 no 3333 0.00177865745718433 4756 7894410
SGTC_2483 5729050 27.16 µM -2.95984993767739 0.00135103394205431 no 3334 0.00153894462421415 4772 2865180
SGTC_939 1165-0479 45.3 µM -2.96428261715052 0.00133137064907342 no 3335 0.00151694755905342 4772 1377347
SGTC_514 4466-0038 2.65 nM -3.00661051239841 0.00115635784531545 no 3336 0.0013208900422853 4704 5722064
SGTC_2200 6600604 21.907 µM -3.03961705302866 0.0010347961861145 no 3337 0.00118439566364789 4798 2904777
SGTC_2006 4011487 200 µM -3.10592449099774 0.000825274271325331 yes 3338 0.000948425730957455 4756 45595294
SGTC_137 0438-0332 85.389 µM -3.11137860957003 0.000809908211044828 yes 3339 0.000931080089217903 4763 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_78 0336-0123 156.75 µM -3.11639411901123 0.000796010713534624 yes 3340 0.000915387058420395 4763 6765896
SGTC_3080 9117754 49.47 µM -3.13943711833018 0.000734938019167081 yes 3341 0.000846363697209531 4791 9550191
SGTC_1053 3366-3204 134 µM -3.17610724006581 0.000646591236213446 yes 3342 0.000746328803739038 4797 3632071 YPR165W RHO1
SGTC_2273 7815444 169.05 µM -3.22553154542371 0.000542983598934206 yes 3343 0.000628694891078544 4785 2824616
SGTC_2653 dihydrofissinolide 100 µM -3.24359579456283 0.00050911408604655 yes 3344 0.00059015556687267 4807 6857746
SGTC_2498 4'-Methoxychalcone 54.63 µM -3.30392174727752 0.000409663020995842 yes 3345 0.000476712205437274 4794 641818 YHR062C RPP1
SGTC_2909 7941780 10.49 µM -3.58402162470572 0.000142697500986833 yes 3346 0.000169172027438299 4800 1243215
SGTC_178 4092-0806 87.505 µM -3.89141141856008 4.11310954225023e-05 yes 3347 4.98313873897564e-05 4784 2169044
SGTC_1971 st069429 63.5 µM -4.06562051863805 1.95174188265061e-05 yes 3348 2.39524153154991e-05 4806 1246522 YGL099W LSG1
SGTC_2460 5552655 174.22 µM -4.10192765551792 1.66472935058064e-05 yes 3349 2.04861194557757e-05 4804 5401989
SGTC_1632 st005650 90 µM -4.13877624455201 1.41471006769662e-05 yes 3350 1.74581638336549e-05 4804 2759605
SGTC_138 0850-0259 40.9225 µM -4.23857861471399 9.04424066055208e-06 yes 3351 1.12469707758744e-05 4794 6813004
SGTC_2469 5655019 90.81 µM -4.34222211028152 5.6253744121462e-06 yes 3352 7.05244156065672e-06 4810 2788239
SGTC_1624 st003710 6.25 µM -4.52073859962638 2.42275727229895e-06 yes 3353 3.08121222171068e-06 4801 24207033
SGTC_304 1310-0298 97 µM -4.69403322142369 1.03814196425263e-06 yes 3354 1.33935251319244e-06 4771 1550234
SGTC_1877 wortmannin 25 µM -5.35816727462524 3.07205327956811e-08 yes 3355 4.2035193579953e-08 4810 312145 A covalent inhibitor of PI 3-kinase.
SGTC_58 0957-0393 9 µM -6.54360265631048 1.94583991633287e-11 yes 3356 3.00271137121234e-11 4741 6997992