SGTCid condition conc unit RAD57|YDR004W.score RAD57|YDR004W.strain.pval RAD57|YDR004W.strain.significant RAD57|YDR004W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_829 1635-0120 117 µM 16.5725152929512 3.04658798049028e-54 yes 1 5.50607257968383e-62 3 285054
SGTC_1707 st032323 6.317 µM 12.3395050523969 5.59912327324408e-31 yes 2 2.77479888419242e-35 5 3132057 YMR211W DML1
SGTC_3247 9135149 49.47 µM 11.981739257565 2.54542175598575e-29 yes 3 2.21466168626617e-33 3 8934436 YOR116C RPO31
SGTC_219 mitoxanthrone 164.414 µM 11.664066816001 6.8767067243629e-28 yes 4 9.72621082836311e-32 4 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1079 idarubicin 2.36 µM 10.3837627903704 1.67382317536661e-22 yes 5 1.46977883462855e-25 2 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_268 camptothecin 39.6153 µM 10.3430771526861 2.42555633153729e-22 yes 6 2.24928021585754e-25 8 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 10.1705768521309 1.1507332716345e-21 yes 7 1.34157439632349e-24 13 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1930 st074634 34.3 µM 10.0703018978934 2.81133914844619e-21 yes 8 3.73741434877119e-24 2 684253 YOR116C RPO31
SGTC_429 1112-0049 25.5 µM 9.31164422557483 1.82870734238961e-18 yes 9 6.29342563362804e-21 3 2836170
SGTC_1082 camptothecin 424.86 nM 9.12546171114492 8.31149079021571e-18 yes 10 3.5715560777968e-20 7 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 9.11964041927647 8.71022071627241e-18 yes 11 3.76869972896884e-20 7 368090
SGTC_558 k064-0027 21.3 µM 8.79761010462305 1.11197000750501e-16 yes 12 6.98803251023457e-19 2 5088526
SGTC_824 1304-0008 100 µM 8.68977628375058 2.55752710833274e-16 yes 13 1.81576949084976e-18 1 768245
SGTC_1718 roemerine 11.9335 µM 8.45902274624088 1.47000225792977e-15 yes 14 1.34813725505017e-17 4 235224 An aporphine alkaloid with mutagenic activity.
SGTC_915 methyl methanesulfonate (MMS) 110 mM 8.35274276865606 3.23931207274428e-15 yes 15 3.33478974696577e-17 4 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_273 hydroxyurea 18.1 mM 8.06310059689205 2.65607687583016e-14 yes 16 3.71916317987687e-16 5 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1290 0986-0249 10.2 µM 7.85717713748688 1.134804262298e-13 yes 17 1.96443527315892e-15 3 53329
SGTC_272 doxorubicin 8.13 µM 7.72110760601717 2.90408884641948e-13 yes 18 5.76615704513951e-15 2 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_244 nsc-207895 1.295 µM 7.58830518583535 7.15594722159765e-13 yes 19 1.62058404386176e-14 6 42640
SGTC_73 0327-0325 16.231 µM 7.13500329821091 1.38748550263942e-11 yes 20 4.83924195150252e-13 9 53298
SGTC_1170 0310-0127 64.8 µM 6.99657932032511 3.3130320493214e-11 yes 21 1.31143653850787e-12 2 774975
SGTC_93 0109-0045 59.227 µM 6.68652954017533 2.19356205098029e-10 yes 22 1.14262517658781e-11 5 88733
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 6.61503943102932 3.35268094854514e-10 yes 23 1.85726360280453e-11 5 165521
SGTC_1425 4048-4433 7.33 µM 6.49686954894585 6.69570824789826e-10 yes 24 4.1004256345352e-11 5 23734946
SGTC_2853 9015042 58.44 µM 6.34721535210846 1.58066625774421e-09 yes 25 1.09623563537759e-10 4 6457456
SGTC_248 streptozotocin 5.23457 mM 6.02425047927955 9.45713776119332e-09 yes 26 8.49475419293077e-10 13 5300 DNA alkylating agent.
SGTC_1105 epirubicin 18.1 µM 6.00628865031908 1.04193582581552e-08 yes 27 9.49090656814044e-10 4 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2308 7584454 197.62 µM 5.54669165994582 1.13309891303847e-07 yes 28 1.45562738393528e-08 5 893577
SGTC_2612 dictamnine 15.46 µM 5.45307313689034 1.80254261160964e-07 yes 29 2.47533477222948e-08 17 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2677 mitomycin C 100 µM 5.27196391306194 4.33330566080111e-07 yes 30 6.7485810334573e-08 8 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1298 1079-1278 263 µM 5.17659500171631 6.80132591711131e-07 yes 31 1.1298600551575e-07 3 2840950
SGTC_2019 4016004 108 µM 4.85340834738836 2.96052572195336e-06 yes 32 6.06787208216254e-07 8 45595336
SGTC_672 1441-0018 53.7 µM 4.84382350077769 3.0883933586168e-06 yes 33 6.36820406183538e-07 6 251141
SGTC_3254 9136651 49.47 µM 4.81881107250591 3.44744280057228e-06 yes 34 7.22081121424652e-07 13 16454030
SGTC_257 daunorubicin 18.5 µM 4.81253802652649 3.54356658041022e-06 yes 35 7.45127525788261e-07 17 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2306 7482397 179.52 µM 4.76654622116501 4.33081635073763e-06 yes 36 9.37053757648318e-07 10 891448
SGTC_1309 pyrazolanthrone 13.4 µM 4.67974759903991 6.29380093013872e-06 yes 37 1.43614148397381e-06 14 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2315 7733312 200 µM 4.59466913061516 9.02374988087289e-06 yes 38 2.16718227503387e-06 14 726316
SGTC_411 enrofloxacin 100 µM 4.58118148803238 9.54887667204337e-06 yes 39 2.31178187853831e-06 4 71188 A bacterial gyrase inhibitor.
SGTC_580 1123-0028 41 µM 4.4536389593162 1.61804987644145e-05 yes 40 4.22135115550702e-06 22 1677248 YPR107C YTH1
SGTC_3344 9148862 3.898 µM 4.42319621892742 1.83143291816905e-05 yes 41 4.86256702929453e-06 6 4905352
SGTC_46 0329-0187a 2.197 µM 4.40734221690833 1.95288187480784e-05 yes 42 5.23233900549929e-06 53 46494817
SGTC_1625 st003711 30.1 µM 4.4050206418537 1.97129525981429e-05 yes 43 5.28869026682342e-06 27 24207034 YER133W GLC7
SGTC_1915 st067105 30.6 µM 4.38839070539281 2.10809363094088e-05 yes 44 5.70962480298026e-06 30 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_318 1488-0629 67.2 µM 4.38300862122032 2.15426313532171e-05 yes 45 5.85257395061435e-06 18 3662576
SGTC_2087 5276107 200 µM 4.32094738988946 2.76081699609578e-05 yes 46 7.7680357892303e-06 14 144405
SGTC_682 0kpi-0099 17 µM 4.31092592703183 2.87279519980578e-05 yes 47 8.12861809650537e-06 56 1714895 YML126C ERG13
SGTC_1632 st005650 90 µM 4.28675090268208 3.16088976538554e-05 yes 48 9.06527010779537e-06 20 2759605
SGTC_2171 5739187 198.077 µM 4.22969942987366 3.95296224318283e-05 yes 49 1.17001876481187e-05 12 2262761
SGTC_1539 benzyladenosine 56 µM 4.19684879149167 4.49065189786603e-05 yes 50 1.35327251967273e-05 12 92208 A nucleotide analog.
SGTC_670 4204-0025 119 µM 4.1852747771941 4.69602978637115e-05 yes 51 1.42410675166644e-05 26 719039
SGTC_631 k072-0230 41.5 µM 4.08625337967437 6.85364961020056e-05 yes 52 2.19197504610896e-05 16 5773147
SGTC_251 melphalan 456.522 µM 4.07168015185352 7.24083906752561e-05 yes 53 2.33376212744926e-05 18 460612 A DNA alkylator.
SGTC_1384 3089-0840 101 µM 4.03034773492194 8.4540627838008e-05 yes 54 2.78471988959099e-05 14 1069836
SGTC_2968 9090663 33.37 µM 4.01839063090491 8.83921460823648e-05 yes 55 2.92984981405996e-05 26 25236811
SGTC_2229 7354935 190 µM 4.01711482378135 8.88127011631331e-05 yes 56 2.94575107620232e-05 10 318112
SGTC_441 propafenone 146 µM 3.99635795955236 9.59248735942519e-05 yes 57 3.21622235138348e-05 5 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1237 0330-0133 46.1 µM 3.98111723766166 0.000101484115112622 yes 58 3.42960527857159e-05 25 X1237 YHR072W ERG7
SGTC_1390 3413-2614 145 µM 3.97892150078289 0.000102309545388676 yes 59 3.46142959042522e-05 27 3421432
SGTC_550 4123-0385 25.7 µM 3.9602617902254 0.000109583121986052 yes 60 3.74338213814987e-05 21 5731123
SGTC_223 busulfan 5 mM 3.9489723697789 0.000114216599737346 yes 61 3.92437047440433e-05 7 2478 A DNA alkylator.
SGTC_546 peri-Naphthalide 147 µM 3.88271163748356 0.000145335484741163 yes 62 5.16490209990778e-05 19 223824 A penicillin ester.
SGTC_2298 7976326 193.81 µM 3.87491624183657 0.000149478692705563 yes 63 5.33306900390983e-05 11 2235818
SGTC_2128 5255449 168.493 µM 3.83793587203367 0.00017068476517524 yes 64 6.20364360477701e-05 39 736008
SGTC_1175 0741-0056 27.6 µM 3.76058224161005 0.000224456608659752 yes 65 8.47591648325849e-05 23 765927
SGTC_2218 6965428 192.983 µM 3.65221947420869 0.000326709144406167 yes 66 0.000129991768248681 10 675684
SGTC_3352 9151559 45.5865 µM 3.64878234147531 0.00033057039612687 yes 67 0.000131743109616573 17 17159339
SGTC_608 k048-0125 159 µM 3.639803234996 0.00034085859773129 yes 68 0.000136423228040933 41 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_830 4076-0286 57.8 µM 3.63783451919154 0.000343153767791994 yes 69 0.000137469987085761 80 6866659
SGTC_1834 st055981 52.8 µM 3.58759045605767 0.000406822194636317 yes 70 0.000166873982467266 42 471719 YDL150W RPC53
SGTC_1845 st056753 3.01 µM 3.58703244935191 0.000407587171218065 yes 71 0.000167231357645794 51 5375839
SGTC_605 1315-0399 119 µM 3.58471772097977 0.000410774726906377 yes 72 0.000168721485130896 36 24020461
SGTC_2858 9025781 8.96 µM 3.57596774654526 0.000423034217624945 yes 73 0.000174467337006287 117 4894980 YPL153C RAD53
SGTC_2662 daunorubicin 22.37 µM 3.51881589567435 0.000511832742110656 yes 74 0.00021673870339716 22 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_799 1310-0557 151 µM 3.50322390582814 0.000538893858829214 yes 75 0.000229831450510867 40 5354492
SGTC_1821 st053465 65.6 µM 3.48388558164051 0.000574294779289995 yes 76 0.000247095353602392 17 675086
SGTC_50 0929-0078 56.389 µM 3.45930023932 0.000622404163606006 yes 77 0.000270790419139569 70 1377751
SGTC_2460 5552655 174.22 µM 3.44407190406945 0.000654042227509255 yes 78 0.000286511643760061 46 5401989
SGTC_1623 st003709 20.3 µM 3.41932125760175 0.000708645242620979 yes 79 0.000313887807210433 100 16192618
SGTC_1995 st072814 61.1 µM 3.40363813959304 0.000745387716128443 yes 80 0.000332473902695879 25 5769371
SGTC_453 enantio-paf c16 10 µM 3.39956624330872 0.000755210273117153 yes 81 0.000337464143284082 196 13871343 A lipid and platelet activating factor
SGTC_1732 st034308 51.822 µM 3.36838824162341 0.000834465009802591 yes 82 0.000378045216413093 47 830119
SGTC_1300 1094-0077 113 µM 3.36199449048117 0.00085163520716582 yes 83 0.000386908337733522 27 5532636
SGTC_247 mechlorethamine 29.705 µM 3.34510488738065 0.000898566532609182 yes 84 0.000411257294359881 29 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 3.34227690600086 0.0009066531405376 yes 85 0.000415470605765203 48 1377
SGTC_2043 5101342 149 µM 3.32995172265727 0.000942683842692739 yes 86 0.000434305215061851 38 678451
SGTC_1653 st012112 65 µM 3.31596883731316 0.000985150184528386 yes 87 0.000456630059274713 29 720429
SGTC_3349 9149703 23.001 µM 3.28466157919557 0.00108667167792055 no 88 0.000510524665397659 30 4910494
SGTC_1085 doxorubicin 7.67 µM 3.25235805112997 0.00120140080926886 no 89 0.000572258734775048 39 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1214 0358-0031 63.7 µM 3.19489421249539 0.00143324681218307 no 90 0.000699410517443989 46 4301366
SGTC_909 3448-9333 149 µM 3.12271550379695 0.00178211094402756 no 91 0.000895954334035061 42 3344074
SGTC_530 4358-1714 28 µM 3.1182418798428 0.00180608740203203 no 92 0.000909667127228856 81 1564641
SGTC_1098 clofazimine 15.1 µM 3.0458671099349 0.00223698697570956 no 93 0.0011600517693963 72 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1953 st076800 12.1 µM 3.00367897868265 0.00252921420087281 no 94 0.00133368303899567 105 297591
SGTC_3005 9076496 71.4286 µM 2.99126044868081 0.00262158056714901 no 95 0.00138914211746333 30 21368410
SGTC_309 k408-0051 1.48 µM 2.98952461282891 0.00263473128044428 no 96 0.00139705967728743 124 3640463
SGTC_1416 3966-0321 25.3 µM 2.98737616971404 0.00265109041751583 no 97 0.00140691630258131 67 582530 YLR208W SEC13
SGTC_2312 7706453 155.7 µM 2.98060432267545 0.00270325612772455 no 98 0.00143840116369067 75 976098
SGTC_1982 st072467 71.9 µM 2.97802205498328 0.00272339100693598 no 99 0.00145057553900638 88 3163533
SGTC_54 0159-0055 9 µM 2.96070369771394 0.00286196380899646 no 100 0.00153468537693119 83 3319099
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 2.95008037242302 0.00295008167992342 no 101 0.00158845636984932 80 5355888
SGTC_2880 9042983 58.44 µM 2.91786247611384 0.00323247221790169 no 102 0.00176219875947169 83 6464714
SGTC_1579 chlormadinone acetate 49.4 µM 2.90994862602744 0.00330545656359432 no 103 0.0018074408524011 50 45114258 A steroidal progestin.
SGTC_2832 7992762 51.95 µM 2.89362927533345 0.00346065590728225 no 104 0.00190408745860897 81 2985177
SGTC_1816 st051957 91.6 µM 2.87559132444355 0.00363978914729772 no 105 0.0020163573393815 49 674121
SGTC_1626 st003712 1.76 µM 2.86779897754102 0.00371971534714565 no 106 0.00206669032527841 80 24207035
SGTC_2671 danthron 100 µM 2.84660303468081 0.00394514580563911 no 107 0.00220942133844596 99 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1604 st002052 72.4 µM 2.83398113483054 0.00408512827841924 no 108 0.00229860229120901 73 6254834 YHR062C RPP1
SGTC_3050 9093513 49.47 µM 2.83083751395 0.00412067672465 no 109 0.00232131497734932 67 25236664
SGTC_2619 obliquin 87.91 µM 2.8291304848562 0.0041400957580058 no 110 0.00233373322984531 237 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1928 4'-methoxychalcone 40.3 µM 2.82532914849518 0.00418363394846365 no 111 0.00236160346884662 49 641818
SGTC_432 NS 1619 61.3 µM 2.81752219960157 0.0042743364752161 no 112 0.00241978844767153 89 4552 A K+/calcium channel activator.
SGTC_2340 7987427 183.45 µM 2.81415903164866 0.00431394927661027 no 113 0.00244525139113939 96 2239331
SGTC_1913 st060213 96.1 µM 2.80113073138443 0.0044705178459813 no 114 0.00254619423632227 116 688959
SGTC_1057 3448-5381 134 µM 2.80050978439311 0.0044781052550203 no 115 0.00255109803544734 80 5497911
SGTC_1522 st012842 45.6 µM 2.78146377427737 0.00471648747045336 no 116 0.00270571848472542 90 3491067 YOR116C RPO31
SGTC_66 0109-0187 42.4 µM 2.77924998633914 0.00474491715848742 no 117 0.00272422885215479 90 759417
SGTC_653 0203-0016 55.2 µM 2.77173448321389 0.00484257554535673 no 118 0.00278792486191386 75 295302
SGTC_2961 9083290 32.55 µM 2.76604537702157 0.00491768859162076 no 119 0.00283703193925064 71 17741490
SGTC_159 3970-0959 50 µM 2.7423798814197 0.00524140338832276 no 120 0.00304978771599017 202 6615653
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 2.70982832856694 0.0057176038874 no 121 0.00336590204538847 82 5393153
SGTC_41 0478-0632 82.643 µM 2.709549270487 0.00572184709863821 no 122 0.0033687348711739 110 3750424
SGTC_972 1319-0219 195 µM 2.70826104984785 0.00574147136328248 no 123 0.0033818398931978 97 23903702
SGTC_1506 4226-2149 212 µM 2.69831330508529 0.00589503403071267 no 124 0.00348459081661917 108 991114
SGTC_1302 1159-0335 255 µM 2.69269758455698 0.00598332274310715 no 125 0.00354382626065229 65 649284
SGTC_456 gingerol 170 µM 2.6876984489802 0.00606290189243854 no 126 0.00359731684092287 90 442793 A herb.
SGTC_362 0310-0100 9.03 µM 2.68625851665637 0.00608599690594733 no 127 0.0036128579189664 112 790235
SGTC_1444 4112-3581 28 µM 2.68006049888875 0.00618629902126393 no 128 0.00368044276066177 80 2877249
SGTC_306 1672-3436 11.6 µM 2.66550088296028 0.00642769672707838 no 129 0.00384368649112525 81 6797378
SGTC_1050 3232-1156 69.3 µM 2.64927379833257 0.00670652902322522 no 130 0.00403324756235361 88 700529
SGTC_3085 9117376 49.47 µM 2.61078853861383 0.00741097048116976 no 131 0.004516686580132 82 16480349
SGTC_837 0091-0265 12.5 µM 2.60978749783944 0.00743013286174547 no 132 0.00452992410318777 109 759367
SGTC_1936 st074407 74.3 µM 2.59684365607926 0.00768187032065638 no 133 0.00470423687322057 145 809813
SGTC_1747 st037496 66.6 µM 2.59013967934276 0.00781518003212481 no 134 0.00479684981080814 106 723305
SGTC_1189 1431-2119 7.28 µM 2.58028952604179 0.00801474390126977 no 135 0.00493587560273725 137 3107275
SGTC_811 0416-0114 265 µM 2.52885743269084 0.0091312015803071 no 136 0.00572172500122193 125 6612453
SGTC_440 fluspirilene 35.1 µM 2.51919102090316 0.00935560192377949 no 137 0.00588124123254752 117 3396 An atypical antipsychotic.
SGTC_236 1509-0011 5.31 µM 2.50336137529949 0.00973350372569924 no 138 0.00615099310962235 519 3107280
SGTC_3030 9087619 49.47 µM 2.48880642284333 0.0100926747215457 no 139 0.00640863659989085 113 25236973
SGTC_2238 6671620 73.2395 µM 2.48732246490665 0.0101299358415564 no 140 0.00643543380736555 115 729941
SGTC_2028 5153890 36.43 µM 2.48495144252738 0.0101897196076577 no 141 0.00647845533911861 117 2830968 YPR165W RHO1
SGTC_1329 1447-1697 50.6 µM 2.4838415923654 0.0102178093382459 no 142 0.00649868053201232 106 2840515
SGTC_1022 4477-0945 21.3 µM 2.48187398269919 0.0102677745482748 no 143 0.00653467429312285 123 4648966
SGTC_839 0122-0028 230 µM 2.45847994290242 0.0108783625029348 no 144 0.00697632850236783 162 759448
SGTC_329 k048-0121 21.3 µM 2.44684700093523 0.0111935784486156 no 145 0.0072055999977907 108 6832902
SGTC_2022 5136654 200 µM 2.44592514190755 0.0112188941353372 no 146 0.00722404976128292 110 1713771
SGTC_42 0133-0086 60.653 µM 2.44297288688403 0.0113003028932483 no 147 0.00728341580175803 117 162923 Model of phenazepam hydroxylation.
SGTC_2094 5332512 191.667 µM 2.43666637038344 0.0114759272315888 no 148 0.00741167439775344 137 755774
SGTC_823 0417-1665 178 µM 2.41661213890408 0.0120502475797246 no 149 0.00783284997849278 136 3429856
SGTC_1357 1503-1303 39.5 µM 2.41047523874807 0.0122309066905088 no 150 0.00796587636492162 160 292895
SGTC_916 4466-0038 42 nM 2.38373080813077 0.0130458797094355 no 151 0.00856906681276945 228 5722064 YGL116W CDC20
SGTC_3035 9091303 49.47 µM 2.38231149660795 0.0130904116738658 no 152 0.00860216882732144 67 25237002
SGTC_1440 4100-1550 40 µM 2.37619799073531 0.0132837324685377 no 153 0.00874603706112129 62 742806
SGTC_1036 k216-0215 33.5 µM 2.37345352328234 0.0133713167625071 no 154 0.00881130536746064 196 622330
SGTC_3228 9131799 49.47 µM 2.37050952839845 0.0134658225459151 no 155 0.00888179303035216 91 17015818
SGTC_90 0870-0863 4.608 µM 2.36689149914182 0.0135827550025702 no 156 0.00896909540574007 176 1738164
SGTC_2179 6298986 200 µM 2.36454498778922 0.0136590603964353 no 157 0.00902611734487875 113 738374
SGTC_2544 sphondin 68.51 µM 2.35614041836437 0.013935408354487 no 158 0.0092329679666496 137 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_843 0310-0051 143 µM 2.35577165969362 0.0139476429927232 no 159 0.0092421379868113 129 2065037
SGTC_2059 5238311 157 µM 2.35387147595548 0.0140108340070932 no 160 0.00928951682641755 151 703021
SGTC_1602 st001878 87.6 µM 2.35385159338943 0.0140114965084904 no 161 0.0092900136961845 123 595405 YLR310C CDC25
SGTC_2846 9008642 19.48 µM 2.34460645058299 0.0143224913578983 no 162 0.00952358622662202 119 2992898
SGTC_1015 4130-4525 82 µM 2.32246414301144 0.0150915928888019 no 163 0.0101039785017391 147 1363237
SGTC_1313 1220-0047 237 µM 2.32028883800727 0.0151690311184711 no 164 0.010162628766671 179 3528706
SGTC_2462 5162487 171.77 µM 2.30480435006835 0.0157301867892043 no 165 0.0105887666874785 136 2259986
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 2.3019353255626 0.0158360921242993 no 166 0.0106694098479647 148 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_108 0509-0257 621.132 µM 2.28505183196721 0.0164717844437372 no 167 0.0111548943565127 216 536624
SGTC_1129 3453-1384 223 µM 2.27506419712501 0.0168580243196446 no 168 0.0114510395148977 189 1084452
SGTC_2088 5278280 127.392 µM 2.25997080031049 0.0174563987492461 no 169 0.0119115315712313 189 791502
SGTC_1474 0330-0125 5.35 µM 2.25610824907308 0.0176124114898689 no 170 0.0120319263244077 132 X1474
SGTC_480 am 92016 50 µM 2.24756732277287 0.01796161862048 no 171 0.0123018966046177 126 2129 K+ channel blocker.
SGTC_2874 9043904 71.43 µM 2.22774370773961 0.0187949517939336 no 172 0.0129488052962007 120 4463428
SGTC_2360 9040895 200 µM 2.22273976574604 0.019010431068481 no 173 0.013116676405042 144 4914414
SGTC_149 3970-0822 46.1 µM 2.20836645931348 0.0196410917566142 no 174 0.0136093689607038 317 3114250 YBL034C STU1
SGTC_3356 9151811 4.48 µM 2.2075650498913 0.019676772176242 no 175 0.0136373038700861 164 1859254 YPR165W RHO1
SGTC_71 0417-1750 47.813 µM 2.20553571045754 0.0197673687925746 no 176 0.0137082623884235 199 6811472
SGTC_1864 st057645 30.4 µM 2.20281436413736 0.0198894145165339 no 177 0.0138039176657197 124 688666
SGTC_1308 1187-1617 41.4 µM 2.19595400765356 0.020199925569616 no 178 0.0140476177430927 205 2882570
SGTC_1034 k072-0165 12.7 µM 2.16897644382095 0.0214611338106786 no 179 0.0150422361719425 190 5835461
SGTC_586 0957-0265 8.15 µM 2.16834023834753 0.0214916623702564 no 180 0.0150664045143466 140 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_168 3970-0862 530.542 µM 2.16628830134203 0.0215903755711518 no 181 0.0151445815583909 400 3135186
SGTC_2958 9077254 16.72 µM 2.16379412101109 0.0217108795727737 no 182 0.0152400767722029 193 16457351
SGTC_3243 9134147 49.47 µM 2.16165367328458 0.0218147458875458 no 183 0.0153224405001574 95 24282180
SGTC_673 1082-0474 110 µM 2.14718089131284 0.0225281139034514 no 184 0.0158894416851441 266 3098046
SGTC_3330 9141424 71.43 µM 2.14169642965648 0.0228035363068188 no 185 0.0161089591096791 191 27261020
SGTC_2477 5967686 25.23 µM 2.13660810412252 0.0230615972825725 no 186 0.0163149399585371 181 776118
SGTC_841 0251-0215 91.2 µM 2.13540215577569 0.0231231177198752 no 187 0.0163640873745292 241 3888614
SGTC_1693 xanthone 101.9 µM 2.13539884726084 0.0231232866908585 no 188 0.0163642223844818 181 7020 An insecticide.
SGTC_52 0329-0193 875 nM 2.1302607800495 0.0233869532492331 no 189 0.0165750447949234 189 3739292
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 2.12133444559805 0.023851034824805 no 190 0.0169468338057839 206 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 2.11777146569165 0.0240384241986978 no 191 0.0170972135126016 168 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_336 4111-0029 111 µM 2.10650741255442 0.0246389950631522 no 192 0.0175801499546192 153 3131175
SGTC_450 aminopyrene 156 nM 2.10258053579118 0.0248513041667315 no 193 0.0177512264285681 227 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_974 1326-0144 138 µM 2.08776564356044 0.0256661425520107 no 194 0.0184094900643874 234 5411856
SGTC_3022 9087993 49.47 µM 2.08340530458711 0.0259101845898435 no 195 0.0186071475802275 146 17173644
SGTC_1817 st052116 64.4 µM 2.08200586968703 0.0259889193488306 no 196 0.018670966790669 178 4361398
SGTC_738 1315-0003 72.4 µM 2.06003049993632 0.0272517685804906 no 197 0.0196978125711856 209 6251474
SGTC_1723 st034307 2.5525 µM 2.05965703913785 0.0272736647948957 no 198 0.019715669584789 211 867466
SGTC_2992 9074591 71.4286 µM 2.04129660035581 0.0283683830173059 no 199 0.0206106773943941 165 17741321
SGTC_1981 st071826 47 µM 2.04067798824232 0.0284058946681786 no 200 0.0206414223332816 161 11838600
SGTC_341 1486-1430 230 µM 2.03677970845034 0.0286432307945964 no 201 0.0208360613141936 217 2054753 YPL210C SRP72
SGTC_2701 st077767 14.721 µM 2.02889197712754 0.0291284996982426 no 202 0.0212346470571729 256 5721188
SGTC_2210 7115885 190.385 µM 2.02652427754695 0.029275491213077 no 203 0.0213555437243454 208 2927039
SGTC_1962 st076595 64.5 µM 2.023820460209 0.0294441025032798 no 204 0.0214943141192326 222 279619
SGTC_1633 st005664 67.9 µM 2.01955422717282 0.0297117859362142 no 205 0.0217148235522593 245 2063822
SGTC_3163 9099914 49.47 µM 2.01845400716297 0.0297811454731172 no 206 0.0217719997825197 110 16268368
SGTC_2768 sulfasalazine 50.2 µM 2.01805586906695 0.0298062777794396 no 207 0.0217927215332704 198 5384001 An antioxidant and salicylic acid derivative.
SGTC_1491 4138-0063 26.5 µM 2.00743541950325 0.030483211086006 no 208 0.0223516602951123 146 23883227
SGTC_623 k072-0108 16.9 µM 2.00361429626507 0.0307298589350304 no 209 0.0225556966171848 220 5382803
SGTC_1525 8-methoxypsoralen 92.5 µM 1.9968902274318 0.0311678991004215 no 210 0.0229185545166978 242 4114 Related to psoralen; DNA damaging agent.
SGTC_3067 9117431 49.47 µM 1.99574347919593 0.0312431172417651 no 211 0.0229809259104036 176 17150885
SGTC_727 3032-0951 202 µM 1.99202602537353 0.0314879874118039 no 212 0.023184101226829 217 3652836
SGTC_883 0850-0245 24.6 µM 1.97892729725489 0.0323634812766603 no 213 0.0239120961887694 261 6823229 YPR165W RHO1
SGTC_335 4077-0256 27.6 µM 1.97595505941358 0.0325649109909377 no 214 0.0240799336739581 236 3121989
SGTC_687 k029-0044 34.9 µM 1.96949232821607 0.033006462612271 no 215 0.0244482913479777 207 5829338
SGTC_295 k015-0027 31 µM 1.95634549151028 0.0339199219208399 no 216 0.0252122343210204 206 3887424
SGTC_446 go6976 132 µM 1.95563604522879 0.0339698006931099 no 217 0.0252540217839081 189 3501 A protein kinase C inhibitor.
SGTC_3341 9147222 25.867 µM 1.9555407816731 0.0339765029435214 no 218 0.025259637368904 212 1939759
SGTC_842 0271-0008 11.1 µM 1.95521041804943 0.0339997540428653 no 219 0.0252791197115323 230 1221709
SGTC_213 1246-0773 967 nM 1.95379731854115 0.0340993561828048 no 220 0.0253625957661312 244 6251622
SGTC_2456 5770359 74.46 µM 1.94784297113282 0.0345216862448513 no 221 0.0257168776510622 222 3118787
SGTC_1958 st076513 41.9 µM 1.94703126299496 0.0345795905073652 no 222 0.0257654933606107 267 732122 YGL099W LSG1
SGTC_59 0330-0160 1.33 µM 1.94389189647974 0.0348042927558646 no 223 0.0259542443336086 423 4293482
SGTC_1843 st055809 45.5 µM 1.93662570776287 0.0353289756859113 no 224 0.0263955565612158 221 16413835
SGTC_399 oxolinic acid 75 µM 1.93485041875979 0.0354581485687617 no 225 0.0265043269798668 189 4628 A DNA gyrase inhibitor.
SGTC_948 3448-0295 75.3 µM 1.93191964845801 0.0356722433269935 no 226 0.0266847121090372 268 678569
SGTC_2903 5923464 63.88 µM 1.92500122912797 0.0361818430582498 no 227 0.027114602236864 185 2876576
SGTC_1637 st007924 17.4 µM 1.92306432041785 0.0363255758347922 no 228 0.0272359862718833 237 683336
SGTC_139 0099-0334 718.624 µM 1.91805180723838 0.0366997117087734 no 229 0.0275522211883873 303 97690
SGTC_1874 staurosporine 7.6 µM 1.91770605913885 0.0367256342514929 no 230 0.027574146508814 270 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_3046 9092212 49.47 µM 1.90496326569858 0.0376915233191786 no 231 0.0283924231667607 207 25236637
SGTC_694 1315-0438 43.2 µM 1.90093408768225 0.038001210567994 no 232 0.028655323256942 200 6793154
SGTC_2329 6138490 200 µM 1.89299023144365 0.0386178651588677 no 233 0.0291795842771094 244 720019
SGTC_1429 4049-0205 9.46 µM 1.89229164273531 0.0386724820571717 no 234 0.0292260669134067 251 22774478
SGTC_1323 1348-1351 11.2 µM 1.88674683789444 0.0391082202664872 no 235 0.0295971923031693 220 6989654
SGTC_2387 9077560 195.08 µM 1.87101767752591 0.0403660816717278 no 236 0.030671315413996 260 5303272
SGTC_896 0964-0007 44.5 µM 1.85417997030785 0.0417487983986266 no 237 0.031856708330176 229 6756758
SGTC_3036 9090181 49.47 µM 1.85359311592057 0.0417976743460227 no 238 0.0318986966118207 194 25236586
SGTC_2546 rhodinyl acetate 100 µM 1.84717281519053 0.0423354188082169 no 239 0.0323610489830003 259 6708682
SGTC_612 0302-0167 22.4 µM 1.84498507180178 0.0425199308387161 no 240 0.0325198551034072 333 235821
SGTC_2307 7538926 6.34 µM 1.84494630636262 0.0425232061304255 no 241 0.032522674834086 318 96582
SGTC_1430 4049-0248 69.1 µM 1.84095302152113 0.0428616932697269 no 242 0.0328142216997142 297 22774488
SGTC_908 3448-7491 47.7 µM 1.84006803586444 0.0429370022576809 no 243 0.0328791246758125 423 1203031
SGTC_1003 4049-0218 100 µM 1.83992057158106 0.0429495613058998 no 244 0.0328899496723065 303 295161
SGTC_1314 1222-0010 41.1 µM 1.83642173930084 0.0432484170512867 no 245 0.0331476534145965 244 3526027
SGTC_945 3381-0768 11.3 µM 1.83101249796691 0.0437137549351918 no 246 0.0335493388323939 292 1126236 YIL048W NEO1
SGTC_3206 9114350 49.47 µM 1.82551762543069 0.0441905871643541 no 247 0.0339614769442851 270 17087243
SGTC_2223 6903751 107.57 µM 1.82450296409809 0.0442790940364164 no 248 0.0340380343187025 191 5598863
SGTC_2875 9039966 71.43 µM 1.81819409012414 0.0448326150175714 no 249 0.034517236486132 221 6463691
SGTC_969 1313-0238 134 µM 1.80554736344494 0.0459589727159577 no 250 0.0354945354575575 331 5212874
SGTC_765 1319-0117 244 µM 1.79715631086133 0.0467187740283374 no 251 0.0361554040907015 262 3487746 YGL099W LSG1
SGTC_690 glyoxal 20.3 µM 1.79423518474186 0.0469856318281615 no 252 0.036387819220819 358 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2029 5175081 200 µM 1.78993705247708 0.047380506174515 no 253 0.036732015712546 325 1380876
SGTC_2769 toremifene 3.73 µM 1.78697584889588 0.0476540992078183 no 254 0.0369706960393857 274 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_622 1348-1566 26.3 µM 1.78489388672374 0.047847213352311 no 255 0.0371392652256043 329 7340407
SGTC_87 0100-0052 35.5 µM 1.78166495242664 0.0481479546915978 no 256 0.0374019427383509 536 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_143 4032-1194 15.74 µM 1.78125063174554 0.0481866535679421 no 257 0.0374357577831503 391 1806963
SGTC_2738 aclarubicin 5.55 µM 1.77870019165243 0.0484254212335504 no 258 0.0376444638806304 192 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2443 5493264 126.67 µM 1.77722299149192 0.0485641462242091 no 259 0.0377657790353953 278 5340055
SGTC_188 3229-0966 278.469 µM 1.77478524688703 0.048793771331001 no 260 0.037966676616823 355 5722370
SGTC_1254 0550-0035 264 µM 1.77296537513736 0.0489657605014938 no 261 0.038117222252286 314 15121435
SGTC_2588 indole-3-carbinol 100 µM 1.77093505175967 0.0491582098912964 no 262 0.0382857513486422 360 3712 Induces cell cycle arrest.
SGTC_2655 perillic acid 100 µM 1.76963772045383 0.0492814967533777 no 263 0.0383937554566863 200 5702197 An apoptosis inducer.
SGTC_697 0508-1955 564 µM 1.769296360982 0.0493139775246896 no 264 0.0384222152054427 326 6243113
SGTC_1493 4348-0038 111 µM 1.76858200735551 0.0493820044565683 no 265 0.0384818277903748 327 800424
SGTC_1700 st030840 7.9285 µM 1.7644512458517 0.0497768416289718 no 266 0.0388280184043709 295 5499307
SGTC_156 3474-0145 5.642 µM 1.75833025107978 0.0503665408411632 no 267 0.0393456666615167 319 2265471
SGTC_2556 citropten 84.59 µM 1.75675541410911 0.0505191582502514 no 268 0.0394797538587152 344 2775 A potential DNA crosslinker.
SGTC_2835 9006588 71.43 µM 1.75190589182847 0.0509914403459161 no 269 0.0398949956428703 337 2345538
SGTC_2370 9071495 200 µM 1.75095771375706 0.0510841903340636 no 270 0.0399765971056459 314 21791103
SGTC_107 0358-0022 2.6945 µM 1.74445500087903 0.0517239031389227 no 271 0.0405398907514295 193 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1557 sumaresinolic acid 42.3 µM 1.74444795101301 0.0517246001183249 no 272 0.0405405049202746 288 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_3256 9138902 49.47 µM 1.7432263581021 0.0518454846989995 no 273 0.0406470415144764 202 17228773
SGTC_652 0437-0092 114 µM 1.74184424918817 0.0519825239829985 no 274 0.0407678507573953 265 3091274
SGTC_1449 4112-4002 201 µM 1.74057813411028 0.05210831464539 no 275 0.0408787765999468 296 2059539
SGTC_132 0417-1715 25.805 µM 1.73880990957659 0.0522843952327208 no 276 0.0410341024734762 297 6769098
SGTC_2766 oltipraz 83.91 µM 1.73808996294309 0.0523562230514401 no 277 0.0410974815959787 290 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_3220 9131269 49.47 µM 1.73610029886152 0.0525551358655911 no 278 0.0412730507759171 249 17722206
SGTC_1799 st045822 46.1415 µM 1.73033373754151 0.0531350263565689 no 279 0.0417853325690457 274 3674992
SGTC_2252 omeprazole 400 µM 1.72900222668616 0.0532696425607869 no 280 0.0419043482798189 196 4594 A proton pump inhibitor.
SGTC_2361 9034121 116 µM 1.72782328173398 0.053389059817167 no 281 0.042009955998969 305 6496917
SGTC_2411 st077133 39.94 µM 1.7201201864819 0.0541745486373393 no 282 0.0427052985340646 376 1403142 YNL221C POP1
SGTC_1210 3013-0140 750 nM 1.71705053407544 0.0544900997163037 no 283 0.0429849695655841 300 905973
SGTC_3292 9120825 59.784 µM 1.716593079047 0.054537248933193 no 284 0.0430267739618333 304 24824900
SGTC_91 0417-1751 58.384 µM 1.70344493015402 0.0559062503102328 no 285 0.0442424177564654 424 6795624
SGTC_212 3807-4682 38.772 µM 1.69685697925953 0.0566023171695019 no 286 0.0448618515897007 460 3125501 YBL034C STU1
SGTC_2002 4023503 131 µM 1.69561339301097 0.0567344743693109 no 287 0.0449795598631842 433 4736863 YCR052W RSC6
SGTC_2611 pyromycin 23.93 µM 1.69445672324564 0.0568576129216657 no 288 0.0450892643108435 345 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1527 coumarin 137 µM 1.69291415156312 0.0570221618353814 no 289 0.0452359046179725 320 323 A hepatotoxic, DNA x-linker.
SGTC_1727 st034309 9.9045 µM 1.69010581714348 0.0573226943248451 no 290 0.0455038560976655 417 870305
SGTC_381 3461-2219 42.7 µM 1.68820110291278 0.0575272347026774 no 291 0.0456863157941315 342 2883159
SGTC_1001 4048-4355 44.4 µM 1.68790204985165 0.0575594010096375 no 292 0.0457150165491889 328 21824233
SGTC_1406 3909-7906 11.9 µM 1.67938035663294 0.0584819574894845 no 293 0.0465389695596027 340 X1406
SGTC_127 0180-0333 59.125 µM 1.65936213573908 0.0606947936310054 no 294 0.048521420692213 448 771601
SGTC_349 k015-0014 24 µM 1.65167236750028 0.0615620375006229 no 295 0.0493006793231523 332 2196908
SGTC_1252 0493-0875 34.8 µM 1.6503016262815 0.0617176395325187 no 296 0.049440629919636 346 3960963
SGTC_3057 9095946 49.47 µM 1.64068781862448 0.0628176110023473 no 297 0.0504311174173918 306 24540043
SGTC_3079 9117512 49.47 µM 1.63254839730907 0.0637607791253273 no 298 0.0512820058764354 273 7185044
SGTC_2047 4141938 200 µM 1.63242424265912 0.0637752505683599 no 299 0.0512950727937593 297 3807862
SGTC_3097 9117246 49.47 µM 1.62833765529233 0.0642530099652874 no 300 0.0517266546168414 361 16423892
SGTC_838 0109-0203 71.4 µM 1.62034564768539 0.0651953831857217 no 301 0.0525790241857544 358 759422
SGTC_3012 9080433 71.4286 µM 1.61932969128028 0.0653159435059335 no 302 0.0526881727815228 354 17688859
SGTC_935 2996-0153 430 µM 1.61813192060985 0.0654583012113474 no 303 0.0528170853210067 345 23738523
SGTC_1103 duloxetine 36.1 µM 1.61073464759054 0.0663428218060535 no 304 0.0536187852747105 424 60835 A selective serotonin reuptake inhibitor.
SGTC_961 1252-1571 372 µM 1.60860486793499 0.0665991962317884 no 305 0.0538513845695008 385 6813498
SGTC_3167 9103034 49.47 µM 1.60827441037853 0.0666390440310582 no 306 0.053887546273796 267 5127859
SGTC_2563 tomatine 8.54 µM 1.6016698190577 0.0674393257485206 no 307 0.0546143212656821 451 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_615 k087-0205 167 µM 1.59706062057287 0.068002211126046 no 308 0.055126097531718 343 9642773
SGTC_1662 st014054 52 µM 1.58288791160312 0.0697557507137921 no 309 0.0567235072377453 311 2838777
SGTC_3279 9140807 49.47 µM 1.58165104640104 0.0699104199827798 no 310 0.0568646269573544 347 45595718
SGTC_133 0724-0033 378.92 µM 1.5803944545079 0.070067826177861 no 311 0.0570082803762412 347 280309
SGTC_1207 2099-0101 141 µM 1.57478302825411 0.0707740670886275 no 312 0.0576532675958306 421 5837381
SGTC_72 0744-0168 198.391 µM 1.5683427204548 0.0715913558276536 no 313 0.0584005855124719 382 677577
SGTC_962 1254-0300 21.5 µM 1.56556219647631 0.0719464403082293 no 314 0.058725572974258 374 7340576
SGTC_1467 k284-1082 293 µM 1.56425589819176 0.0721137255795993 no 315 0.0588787423110653 386 3334705
SGTC_2812 7970281 58.44 µM 1.56389927496082 0.0721594467156477 no 316 0.0589206124113425 409 2233435
SGTC_2805 7950783 58.44 µM 1.56261590996983 0.0723241653062994 no 317 0.0590714819109737 449 1178958 YDL195W SEC31
SGTC_1838 st055369 84.5 µM 1.56243838438341 0.0723469732008067 no 318 0.0590923752556808 345 676036
SGTC_1398 3558-0053 112 µM 1.55655694485791 0.0731057208508334 no 319 0.0597878563832917 306 4532369
SGTC_509 pifithrin 175 µM 1.55648311850353 0.0731152835261942 no 320 0.0597966269369552 316 4817 A p53 inhibitor.
SGTC_2784 7567673 72.73 µM 1.55599177702549 0.0731789510249924 no 321 0.0598550238684104 440 3471247
SGTC_3193 9111931 49.47 µM 1.55564653468063 0.0732237125242561 no 322 0.0598960833370431 392 17087244
SGTC_3008 9078912 71.4286 µM 1.55140909776911 0.0737748140836019 no 323 0.0604018381790069 367 16648731
SGTC_2580 diallyl disulphide 81.36 µM 1.55133114872828 0.0737849813912412 no 324 0.0604111729115724 367 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_3123 9126162 49.47 µM 1.55064096139469 0.0738750529215836 no 325 0.0604938750684058 371 25239884
SGTC_3185 9108267 49.47 µM 1.54897421808486 0.0740929144053032 no 326 0.0606939589594949 407 4910486
SGTC_29 0299-0004 12.984 µM 1.54372829371712 0.0747818176132916 no 327 0.0613270844830249 296 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1702 st027038 51 µM 1.54063535444651 0.075190271345558 no 328 0.0617027791527715 420 5521182
SGTC_777 1315-0167 517 µM 1.53962752513753 0.075323732123053 no 329 0.0618255860520167 379 4221767
SGTC_722 3534-0461 190 µM 1.53808586978964 0.0755282335450862 no 330 0.0620138102234922 412 658262
SGTC_2253 7938677 135.83 µM 1.53322964588265 0.0761751799412422 no 331 0.0626096411031633 377 2301972
SGTC_3130 9127414 49.47 µM 1.53294018619623 0.0762138745633138 no 332 0.0626452965822622 360 1494646
SGTC_1230 0170-0365 3.77 µM 1.53243018613385 0.0762820871531767 no 333 0.0627081566047752 560 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_3112 9123419 49.47 µM 1.5319131653852 0.076351286174801 no 334 0.0627719321278771 429 17015854
SGTC_2987 9018338 71.43 µM 1.52712652565898 0.07699420881856 no 335 0.0633647760668239 412 5055682
SGTC_2165 5727197 32.143 µM 1.52686309068414 0.0770297114688406 no 336 0.0633975296203657 411 1361712
SGTC_1992 st073643 23.3 µM 1.52556081713449 0.0772053992947859 no 337 0.0635596383039931 386 3161292
SGTC_1321 1326-2144 215 µM 1.52352898720118 0.0774801183325902 no 338 0.0638132071140286 361 3513030
SGTC_625 k213-0058 121 µM 1.52325849699306 0.0775167466111901 no 339 0.0638470230822168 591 3655420
SGTC_2762 leflunomide 42.06 µM 1.52262585917771 0.0776024662427971 no 340 0.063926168202796 456 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2446 5162541 200 µM 1.52207346314345 0.0776773723068676 no 341 0.0639953371817093 390 1549321
SGTC_214 4373-3496 70 µM 1.52058173373242 0.0778799282017698 no 342 0.0641824167756238 577 3779166
SGTC_2657 nystatin 74.44 µM 1.51810555583834 0.0782170429305985 no 343 0.0644938954030812 416 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_701 4424-0219 185 µM 1.51481788364475 0.0786663458457552 no 344 0.0649092651299756 454 2911779
SGTC_1959 st077091 55.8 µM 1.51474468585174 0.0786763714828806 no 345 0.0649185366335758 443 821356 YKL052C ASK1
SGTC_1336 1486-0901 104 µM 1.51336055084972 0.0788661337706872 no 346 0.0650940498909462 406 5006114
SGTC_282 k297-0036 65.7 µM 1.51178961748595 0.0790819256257399 no 347 0.0652936957570376 352 5061378
SGTC_3227 9130768 49.47 µM 1.50349278037657 0.0802290468494103 no 348 0.0663560086405161 362 17720899
SGTC_803 4488-1585 147 µM 1.50052950494665 0.080641783201077 no 349 0.0667386482924384 373 747204
SGTC_3077 9117319 49.47 µM 1.49779455543862 0.0810241386363957 no 350 0.0670933179139315 352 17154678
SGTC_836 0330-0104 1.35 µM 1.49685717805281 0.0811555016140368 no 351 0.0672152123140947 419 46494820
SGTC_2525 harmine 47.85 µM 1.49640827944274 0.0812184666232689 no 352 0.0672736466560564 338 5280953 A monoamine oxidase inhibitor
SGTC_433 pimozide 108 µM 1.4953545712329 0.0813664103755293 no 353 0.06741096497886 321 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_827 3253-0474 693 µM 1.4927377885139 0.0817346935468999 no 354 0.0677529187982399 454 5402065
SGTC_740 k014-0057 261 µM 1.49097062407292 0.0819841122670318 no 355 0.0679846037935201 473 4012779
SGTC_2455 5377712 9.75 µM 1.49019780064364 0.0820933691304118 no 356 0.0680861172585396 385 2243908
SGTC_3099 9120367 49.47 µM 1.48447601200577 0.0829056940220374 no 357 0.0688413412013788 426 24824940
SGTC_1796 st049173 110.4 µM 1.47462253475733 0.0843187471326822 no 358 0.0701570264926419 358 94134
SGTC_741 4582-0002 126 µM 1.47283056739135 0.0845776579625665 no 359 0.0703983639114503 442 2912688
SGTC_2755 lomerizine 42.69 µM 1.47105488748019 0.0848348033012183 no 360 0.0706381369014557 459 3949 A calcium channel blocker.
SGTC_3296 9122258 64.045 µM 1.46973566689411 0.0850262256145089 no 361 0.0708166794234971 457 4730474
SGTC_1980 st071811 45.7 µM 1.46642150184355 0.0855085475270175 no 362 0.0712667460502876 426 4974850
SGTC_148 3253-0744 288.01 µM 1.46457079982702 0.0857787766479343 no 363 0.0715190267766572 410 6893655
SGTC_754 3474-0146 171 µM 1.46379821624417 0.0858917739052745 no 364 0.0716245449881961 412 24762078
SGTC_2973 9094665 17.96 µM 1.46319823231731 0.0859796037406406 no 365 0.0717065721819953 494 25237061 YIL048W NEO1
SGTC_607 4491-0986 66.8 µM 1.46101901347945 0.0862991783753266 no 366 0.072005111797612 481 698981 YDR232W HEM1
SGTC_1776 st049249 45.9 µM 1.45991868081798 0.0864608753349144 no 367 0.0721562122298364 458 1822314
SGTC_3301 9125354 19.7965 µM 1.45975486500664 0.0864849678854862 no 368 0.0721787285967099 396 41905162
SGTC_3189 9110682 49.47 µM 1.4582242599761 0.0867103180361821 no 369 0.0723893694753055 436 17122418
SGTC_2711 st079103 59.1 µM 1.45617438038912 0.0870128077047747 no 370 0.0726722099560581 397 54693780
SGTC_973 1325-0077 65.9 µM 1.45515973282433 0.0871628250815885 no 371 0.0728125228421122 471 2835149
SGTC_2293 7624732 200 µM 1.45373138318952 0.0873743362172519 no 372 0.0730103968642247 413 894453
SGTC_3161 9100388 49.47 µM 1.44926327889081 0.0880384503263522 no 373 0.0736320359273223 435 25236368
SGTC_753 1322-0200 289 µM 1.44923458172347 0.0880427278436182 no 374 0.0736360415484427 443 5403907
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.44557634686646 0.088589283636833 no 375 0.0741480324317744 537 688664
SGTC_2295 7971645 200 µM 1.44304986944726 0.0889682229039458 no 376 0.0745032117790705 463 2978226 YKL099C UTP11
SGTC_3013 9080133 71.4286 µM 1.44176240665275 0.0891617893296808 no 377 0.074684705769493 493 17050193
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.43953506797184 0.089497403257787 no 378 0.074999490821738 487 6708561
SGTC_2432 5630864 12.22 µM 1.43387766997211 0.0903540787859218 no 379 0.0758035876046641 464 5714970
SGTC_1993 st073995 70.8 µM 1.4313281795293 0.0907421216383751 no 380 0.0761680906745642 454 3098394
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.43011484165224 0.0909272303817612 no 381 0.0763420305902396 503 442882
SGTC_3320 9137005 35.139 µM 1.42845535348499 0.0911808579089091 no 382 0.0765804182431142 445 4908713
SGTC_115 0527-0192 112.043 µM 1.42641621090187 0.0914932277418672 no 383 0.0768741185510022 565 4233931
SGTC_3053 9095903 49.47 µM 1.42512182519506 0.0916919217039966 no 384 0.0770609943830194 435 17174018
SGTC_1227 3909-8010 46.6 µM 1.42103669597325 0.0923211037247093 no 385 0.0776530458264031 444 15982272
SGTC_1307 1187-1599 12.2 µM 1.42099329152735 0.0923278058877028 no 386 0.077659354853855 459 1538471
SGTC_1168 k815-0004 80.5 µM 1.41926724559596 0.0925946198759641 no 387 0.0779105587855008 475 642433
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.41849147245765 0.0927147253151095 no 388 0.078023663300684 463 4330530
SGTC_2108 5365811 200 µM 1.41632971772575 0.0930500166682588 no 389 0.0783394954225473 473 780283
SGTC_2635 hydroquinidine 100 µM 1.41462480891255 0.0933150820449234 no 390 0.0785892654372198 467 442912 An experimental heart treatment.
SGTC_45 0kpi-0036 14.9 µM 1.41003956843163 0.0940307249583095 no 391 0.0792639997922988 437 2795021
SGTC_548 1436-0017 110 µM 1.40748851185097 0.094430631159023 no 392 0.0796412907161202 574 9677137
SGTC_914 3820-6779 408 µM 1.4057577824634 0.0947026551710706 no 393 0.0798980311166789 451 2893481
SGTC_1501 4491-0275 38.4 µM 1.40134704137447 0.0953985154159042 no 394 0.0805551602625658 453 5104718
SGTC_1945 st075991 56.6 µM 1.39889131883403 0.0957875697549313 no 395 0.0809227881163504 455 1084980
SGTC_1473 k844-0725 134 µM 1.39200773915236 0.0968843382042865 no 396 0.0819600272066223 532 54682906
SGTC_2704 st078022 71.1 µM 1.37479258230837 0.0996675578511648 no 397 0.0845978792227219 481 54697681
SGTC_2111 5486399 200 µM 1.37395296461757 0.0998047799009616 no 398 0.0847281425362921 548 689674
SGTC_3239 9133757 49.47 µM 1.37168564121416 0.100176026995503 no 399 0.0850806601307572 460 17036923
SGTC_1631 benzylvanillin 81.9 µM 1.36823483979485 0.100742987609559 no 400 0.0856192897382364 517 75506
SGTC_2939 9044578 71.43 µM 1.36708217631316 0.10093288859916 no 401 0.0857997746588713 493 2653634
SGTC_3198 9112019 49.47 µM 1.36627524284263 0.10106598587475 no 402 0.0859262942753488 479 45595555
SGTC_1746 st038117 42 µM 1.36609979250749 0.101094941939464 no 403 0.0859538217150191 510 2898218
SGTC_1855 st056195 39.6 µM 1.36116820168515 0.101911319583973 no 404 0.0867302702760572 496 4028379
SGTC_684 1140-0066 328 µM 1.35804569667721 0.102430695010923 no 405 0.0872245922772929 559 6813534
SGTC_725 1497-0963 19 µM 1.35717857892027 0.102575266116851 no 406 0.0873622376925207 511 3549977
SGTC_211 3455-0679 143.504 µM 1.35560056887738 0.102838741963954 no 407 0.087613145377245 526 748649
SGTC_2830 7992007 71.43 µM 1.35547810354251 0.102859210196208 no 408 0.0876326401434649 487 1952075
SGTC_2719 novobiocin 32.65 µM 1.35544361904698 0.102864974293196 no 409 0.0876381301761649 407 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_3154 9100113 49.47 µM 1.35495943490323 0.102945930645932 no 410 0.0877152408091181 497 25237525
SGTC_519 k048-0011 62.8 µM 1.35415563205303 0.103080429937311 no 411 0.0878433653109104 509 6836379
SGTC_707 0865-0008 204 µM 1.35305959054994 0.103264034748121 no 412 0.0880182969144029 513 723043
SGTC_2380 9035439 200 µM 1.34855068165065 0.104021848136548 no 413 0.0887406654035935 573 6462575
SGTC_3223 9129970 49.47 µM 1.34614641540341 0.10442757833174 no 414 0.0891276510677621 551 17248386
SGTC_334 1502-1024 68.5 µM 1.34541597539634 0.104551070010659 no 415 0.0892454695405615 518 3296216
SGTC_2883 9059145 45.46 µM 1.34404402849949 0.104783303807208 no 416 0.0894670749230372 470 16476510
SGTC_3184 9108758 49.47 µM 1.34293721190264 0.104970930220614 no 417 0.0896461528805297 487 902885
SGTC_2824 7998404 51.95 µM 1.3408986832212 0.105317135751321 no 418 0.0899766749088223 484 837851
SGTC_905 2-aminofluorene 215 µM 1.33752113749962 0.105892564857082 no 419 0.0905262936603376 553 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1771 st048882 4.1505 µM 1.33714336830359 0.105957066033316 no 420 0.0905879216478933 511 4580403
SGTC_1278 0874-0585 172 µM 1.33501698528268 0.106320659253159 no 421 0.0909353936868458 525 766306
SGTC_3196 9111891 49.47 µM 1.3343165264954 0.106440628755909 no 422 0.091050071817333 478 18891510
SGTC_1272 0839-0021 27 µM 1.33229393052737 0.10678759285143 no 423 0.0913818104079723 544 5027250
SGTC_2956 9076196 2.52 µM 1.33062636309247 0.107074267174952 no 424 0.0916559917480982 534 16423868
SGTC_1203 3992-3522 103 µM 1.32885687639525 0.107379069133213 no 425 0.0919475966940207 571 5322312
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.32800529978998 0.107525979717404 no 426 0.0920881780508193 504 803109
SGTC_2600 tangeritin 87.95 µM 1.32762149257132 0.107592239933377 no 427 0.0921515903385682 500 68077 A bioactive flavone.
SGTC_2945 9067681 61.76 µM 1.32547815472422 0.107962805269124 no 428 0.0925063051183899 489 16456930
SGTC_860 0443-0016 25.1 µM 1.31373515375765 0.110009389317076 no 429 0.0944676732697928 527 5337942
SGTC_3285 9112818 20.8695 µM 1.31176715344812 0.110355080287939 no 430 0.0947993553839555 586 17017947 YPR165W RHO1
SGTC_2040 5100729 123 µM 1.310772793916 0.11053004137353 no 431 0.0949672683637999 559 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_22 0964-0034 14.468 µM 1.31001804790991 0.110662974289611 no 432 0.0950948650858236 567 138402
SGTC_900 1112-0045 141 µM 1.30817807183086 0.110987528114594 no 433 0.0954064589281404 415 56211 YIL048W NEO1
SGTC_3088 9117578 49.47 µM 1.30702581438703 0.111191121927883 no 434 0.0956019722221366 513 678341
SGTC_202 3594-0513 34.79 µM 1.30677517874057 0.111235442440837 no 435 0.0956445387107512 503 708429
SGTC_2146 5545642 200 µM 1.30567667870334 0.111429842078867 no 436 0.0958312660249126 543 825326
SGTC_2885 9057732 51.95 µM 1.30275447595418 0.11194816264138 no 437 0.096329298635085 528 6471414
SGTC_1255 0566-0045 221 µM 1.30105536010677 0.112250331774948 no 438 0.0966197530508742 567 2788469
SGTC_2587 piperic acid 92.2 µM 1.29989112933861 0.11245771370507 no 439 0.0968191429178741 495 5370536
SGTC_2979 9012552 45.46 µM 1.29787912567148 0.112816752578741 no 440 0.0971644370633329 475 17100905
SGTC_1721 st082152 9.2685 µM 1.29649717653287 0.113063832846811 no 441 0.097402126081367 509 5296051
SGTC_1931 st074438 57.1 µM 1.2927862054414 0.113729231750006 no 442 0.0980425063513782 512 2787313
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.29264266536765 0.11375502528076 no 443 0.0980673380353535 447 279621
SGTC_99 0109-0120 622.8 µM 1.29234291437172 0.113808902683379 no 444 0.0981192082527645 490 759414
SGTC_604 1000-0114 314 µM 1.28963902581169 0.114295723077209 no 445 0.0985880095712621 585 1572745
SGTC_1101 ebselen 5.29 µM 1.28844243219244 0.114511635874826 no 446 0.0987959980430976 584 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2318 6029776 164 µM 1.28712418614312 0.114749835500146 no 447 0.0990255033080646 570 818325
SGTC_1392 3455-1037 33.9 µM 1.27993468363602 0.116055142806085 no 448 0.10028405414934 564 981132
SGTC_2654 protoveratrine a 100 µM 1.27923704075705 0.116182363775054 no 449 0.100406797896713 548 5702278 A heart drug and vasodilator.
SGTC_638 3970-0837 4.09 µM 1.27773159013956 0.116457232336729 no 450 0.100672041324637 576 4118451 YLR208W SEC13
SGTC_650 1328-0195 38 µM 1.27550364033469 0.116864862372294 no 451 0.10106551823984 580 2780821
SGTC_947 3447-0010 211 µM 1.27459829483772 0.117030794796485 no 452 0.101225730672486 541 748350
SGTC_812 4251-0442 148 µM 1.27446364268688 0.117055488201615 no 453 0.10124957488831 547 5723007
SGTC_161 4065-0411 162.148 µM 1.27363796543062 0.117206987105669 no 454 0.101395875388227 619 1906281 YLR208W SEC13
SGTC_2680 butyl paraben 22.24 µM 1.27352964029512 0.117226873381297 no 455 0.10141508077564 507 7184 An antifungal and steroid mimetic.
SGTC_2985 9022375 71.43 µM 1.27213266065223 0.117483544400232 no 456 0.101662994236108 566 4939335
SGTC_1749 st037932 54.2 µM 1.26947444202026 0.117973044808057 no 457 0.10213595020967 534 594497
SGTC_2428 5615643 7.78 µM 1.26800715090306 0.118243857807462 no 458 0.102397698448043 550 2253075
SGTC_1258 0671-0043 57.1 µM 1.26380599270624 0.119021681576285 no 459 0.103149834865 574 4298767
SGTC_593 1203-0218 61.7 µM 1.26319772336691 0.11913459837126 no 460 0.103259065414286 589 3666956
SGTC_2990 9074105 71.4286 µM 1.26130571501931 0.119486306946737 no 461 0.103599361478443 521 6502001
SGTC_2057 5236571 38.335 µM 1.25703189699766 0.120283468613843 no 462 0.104371042845897 615 54684039 YBR257W POP4
SGTC_2365 9042475 200 µM 1.25550583013736 0.120569019611725 no 463 0.104647596491583 588 6464479
SGTC_2484 5809818 12.04 µM 1.24775667975307 0.12202637200126 no 464 0.106060088737981 577 2870548
SGTC_2553 4-methylesculetin 85.09 µM 1.247278138246 0.122116773268499 no 465 0.106147765297249 590 5319502
SGTC_1859 st055998 20 µM 1.2471481633579 0.122141334940983 no 466 0.106171587842427 612 676301
SGTC_2952 9073731 13.78 µM 1.24712720636503 0.12214529555989 no 467 0.106175429322176 627 16457353
SGTC_902 1120-0002 2.07 µM 1.24321279851817 0.122886653422287 no 468 0.10689471384189 608 3280475
SGTC_869 0564-0080 44.1 µM 1.24311486671067 0.122905241299555 no 469 0.106912754079833 603 6843321
SGTC_667 1498-1044 59 µM 1.24295035802632 0.122936470190887 no 470 0.106943063537284 607 6739982
SGTC_316 k060-0003 58.6 µM 1.24106146273593 0.123295440277834 no 471 0.107291522211562 580 6152314
SGTC_2747 doxorubicin 7.63 µM 1.23999715996049 0.123498026059426 no 472 0.107488222304696 393 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_479 n-linoleoylglycine 10 µM 1.23997860280495 0.123501560406659 no 473 0.107491654266157 546 6433346 An anti-infammatory.
SGTC_2524 avocatin b 10.57 µM 1.23780285035341 0.123916439713061 no 474 0.107894585654222 544 6710748
SGTC_2714 st079313 56.9 µM 1.23685336688987 0.124097795579394 no 475 0.108070762655136 561 2939799
SGTC_937 3122-0005 46.7 µM 1.23530119901461 0.12439466681773 no 476 0.10835921383672 623 759535
SGTC_2713 st079149 53.4 µM 1.2352623359311 0.124402106228957 no 477 0.108366443162179 623 3103253
SGTC_2117 5521686 200 µM 1.23453580650072 0.124541240251909 no 478 0.108501656337884 587 803312
SGTC_3248 9135562 49.47 µM 1.23336847590087 0.124765017654887 no 479 0.108719160380177 649 17650701
SGTC_2285 7945142 200 µM 1.23275818289632 0.124882122676857 no 480 0.1088329985714 565 2970608
SGTC_2140 5586273 200 µM 1.23244804020778 0.124941663292688 no 481 0.108890882439591 552 854421
SGTC_3140 9094243 49.47 µM 1.23146512304772 0.125130492907245 no 482 0.109074476627636 610 19291112
SGTC_743 1275-0778 158 µM 1.23032298298352 0.125350161294345 no 483 0.109288090583367 630 2849257 YMR203W TOM40
SGTC_1605 st000082 49.1 µM 1.22723993487981 0.125944469149714 no 484 0.109866211914727 592 1114022
SGTC_2923 7992654 58.14 µM 1.22630256559905 0.126125551270993 no 485 0.110042418123392 585 2985126
SGTC_471 1-acyl-paf 4 µM 1.22399446011837 0.126572207266157 no 486 0.110477158695622 587 16759367
SGTC_1735 st034310 56.75 µM 1.22249192944056 0.126863562804311 no 487 0.110760827007797 605 871153
SGTC_3275 9138069 49.47 µM 1.22240210698007 0.1268809950445 no 488 0.110777801439114 575 17617007
SGTC_807 1315-0151 48 µM 1.22072650601627 0.127206492019489 no 489 0.111094794223424 687 4011080
SGTC_2126 5251174 33.877 µM 1.21919493843278 0.127504517310958 no 490 0.11138510630476 696 790722
SGTC_3109 9122853 49.47 µM 1.21710328067189 0.127912313441544 no 491 0.11178246132795 643 1234709
SGTC_1514 1189-1591 158 µM 1.21697366103098 0.127937614277873 no 492 0.111807118664131 644 767698 YMR146C TIF34
SGTC_2131 toluylene red 5.2905 µM 1.21360886182872 0.128595616203233 no 493 0.11244856070757 600 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1819 st053448 58.6 µM 1.21253366697329 0.128806369757532 no 494 0.112654081606814 596 2857616
SGTC_2937 9044753 11.33 µM 1.21161408760566 0.128986810453663 no 495 0.112830069692489 636 6465530 YGL099W LSG1
SGTC_2565 isoliquiritigenin 100 µM 1.20927332547389 0.129446907666347 no 496 0.113278927630967 494 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_606 k015-0008 38.6 µM 1.20492752610858 0.130304125028922 no 497 0.114115640615476 667 1970475
SGTC_2346 9031566 143.75 µM 1.20316477413753 0.130652948324445 no 498 0.114456281720797 605 4771086
SGTC_1461 k072-0203 53.8 µM 1.19867714015875 0.13154389869983 no 499 0.115326755078978 592 5418714
SGTC_419 nsc-638432 893 µM 1.1985655568447 0.13156610514627 no 500 0.115348458858603 623 368090
SGTC_184 1494-0393 24.714 µM 1.19829595284073 0.131619770323808 no 501 0.115400910811175 642 3090647
SGTC_2473 5854593 8.94 µM 1.19687496438046 0.131902870351933 no 502 0.115677646828351 593 2872951
SGTC_3321 9137793 26.8275 µM 1.1963562760892 0.132006311905517 no 503 0.115778778172408 649 4904192
SGTC_3078 9116413 49.47 µM 1.19546243887274 0.132184700328017 no 504 0.115953201551959 570 17177322
SGTC_2868 9035608 32.47 µM 1.19325740589746 0.132625482394392 no 505 0.116384289223492 617 6462614
SGTC_1096 rimcazole 32.2 µM 1.18889913065356 0.133499669396801 no 506 0.11723968114307 581 18528119 A dopamine reuptake inhibitor.
SGTC_1943 st076331 65.2 µM 1.18889401717494 0.13350069738535 no 507 0.11724068736621 646 24208415
SGTC_163 TUB2.036 7.546 µM 1.18730076862318 0.133821261364089 no 508 0.117554502519265 804 15992207 YJR013W GPI14
SGTC_3298 9116858 71.43 µM 1.18630927272422 0.134021018682201 no 509 0.117750093024901 665 2506942
SGTC_455 paf C-16 10 µM 1.18559911020478 0.134164221449449 no 510 0.117890326911562 601 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2011 4012611 177 µM 1.18261723502659 0.13476665726293 no 511 0.118480439395559 635 2049887
SGTC_633 0437-0093 97.7 µM 1.18055669543075 0.135184036198352 no 512 0.11888943762453 615 2831118
SGTC_2149 5554786 194.827 µM 1.18021097526882 0.135254151340326 no 513 0.118958157477398 670 745063 YPR165W RHO1
SGTC_3343 9148379 18.9835 µM 1.17905326077895 0.135489127701744 no 514 0.119188484144944 641 1955036
SGTC_1876 myriocin 605 nM 1.17851562091569 0.135598345228799 no 515 0.11929555427377 638 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1341 1486-1360 280 µM 1.17779986319538 0.135743839647472 no 516 0.119438201605538 642 3976547
SGTC_1251 0490-5699 265 µM 1.17597122707066 0.136116037918678 no 517 0.119803187025768 697 3883818
SGTC_2420 aureobasidin a 50 nM 1.17528620044234 0.136255647045087 no 518 0.119940116738569 686 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2451 5856223 45.7 µM 1.17497589299007 0.136318920254599 no 519 0.120002180270401 623 2179896
SGTC_2867 9039098 71.43 µM 1.1721053221381 0.136905196865964 no 520 0.120577386714515 641 6463460
SGTC_2278 7948257 134.34 µM 1.17122954746976 0.137084404974611 no 521 0.120753260747964 641 1247028
SGTC_3110 9122132 49.47 µM 1.16708645139072 0.137934370913469 no 522 0.121587729375369 663 918317
SGTC_723 4182-0001 115 µM 1.16546273438026 0.138268458748094 no 523 0.121915868127674 614 744821 YLR208W SEC13
SGTC_2192 5915882 198.485 µM 1.16453422186213 0.138459752526312 no 524 0.122103791561957 591 2876149
SGTC_644 1498-1197 63.3 µM 1.16219336528577 0.138942820110348 no 525 0.122578464534956 682 6741615
SGTC_1407 3909-7909 12.3 µM 1.16146732712796 0.139092880824551 no 526 0.122725951407218 670 4411780
SGTC_1862 st057513 3.81 µM 1.15901311008318 0.139600945528432 no 527 0.123225420608903 639 5393163
SGTC_1002 4049-0206 172 µM 1.15844175792173 0.139719406020872 no 528 0.123341903290128 702 4662749
SGTC_1420 4'-methoxyflavone 42 µM 1.15801692757058 0.139807531908616 no 529 0.123428564274878 655 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_3205 9113483 49.47 µM 1.15618580438527 0.140187808485467 no 530 0.123802582508263 688 17018033
SGTC_2402 5553605 200 µM 1.15596830303114 0.140233024490426 no 531 0.123847061165736 675 6758546
SGTC_1873 rapamycin 2 nM 1.15559971783272 0.140309671686193 no 532 0.123922461749525 694 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2630 antimycin a 100 µM 1.15483719228581 0.140468328972294 no 533 0.124078551731347 690 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2515 chrysin 20.77 µM 1.15328417348756 0.140791839265202 no 534 0.124396881991503 668 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_146 3448-8650 53.125 µM 1.15296122450788 0.14085917640723 no 535 0.124463150171471 796 2891488 YIL048W NEO1
SGTC_1030 k029-0042 36.7 µM 1.15110313891186 0.14124702482213 no 536 0.124844903409919 711 6080581
SGTC_2806 7952793 58.44 µM 1.15060155562098 0.141351847036781 no 537 0.124948096364868 657 2972490
SGTC_1770 st043884 66.3 µM 1.14975134627997 0.141529646460566 no 538 0.125123149777968 667 670149
SGTC_8 0354-0001 70 µM 1.14942715686328 0.141597482231578 no 539 0.125189943674621 769 4993152
SGTC_1833 st055984 71 µM 1.14720328714924 0.142063414827002 no 540 0.125648806669659 662 676288
SGTC_3221 9128209 49.47 µM 1.1425334400728 0.14304518920073 no 541 0.126616177172076 624 16460723
SGTC_2984 9022109 38.96 µM 1.1421760649916 0.143120511023283 no 542 0.126690421408887 634 6459207
SGTC_780 0109-0199 192 µM 1.13998243823084 0.143583435621362 no 543 0.12714680885274 724 610414
SGTC_1097 itavastatin 7.23 µM 1.13897192599063 0.143797025291068 no 544 0.12735743189476 698 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_3146 9095609 49.47 µM 1.13893889686028 0.143804010199079 no 545 0.127364320314218 682 17173999
SGTC_2628 lathosterol 100 µM 1.13712510158887 0.144187938009112 no 546 0.127742995896699 678 6710616
SGTC_2231 micatex 6.853 µM 1.13623924206948 0.144375699704405 no 547 0.127928225597067 635 20737 An antifungal of unknown mechanism.
SGTC_463 ikarugamyin 104 µM 1.13301665038094 0.145060131329212 no 548 0.128603630582914 618 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2182 6325192 200 µM 1.13285878811498 0.145093714997411 no 549 0.128636779513215 647 736248
SGTC_302 1094-0063 18.9 µM 1.13283745161835 0.145098254531834 no 550 0.128641260342327 608 5440289
SGTC_468 gf-109203x 121 µM 1.1325834241943 0.145152308528898 no 551 0.128694616384643 537 2396 A protein kinase C inhibitor.
SGTC_1679 SEC14.276 6.7 µM 1.13059605597557 0.145575664407663 no 552 0.129112574147788 728 1005053 YMR079W SEC14
SGTC_2720 fluspirilene 36.88 µM 1.1305303583802 0.145589673693867 no 553 0.129126406873439 611 3396 An atypical antipsychotic.
SGTC_2271 7849410 118.62 µM 1.12594573727673 0.14656953262851 no 554 0.130094244084286 694 972430
SGTC_960 1222-0186 7.7 µM 1.12516052573855 0.146737796727238 no 555 0.130260508552833 707 3126296
SGTC_2363 9053361 176 µM 1.12365375154367 0.147061048364637 no 556 0.130579971768092 688 6469797 YMR079W SEC14
SGTC_1339 1486-1321 22.7 µM 1.12262782302585 0.147281416134214 no 557 0.130797796817903 680 3469382
SGTC_2887 9044784 58.44 µM 1.12086122152848 0.147661397693274 no 558 0.131173469799689 733 6465546
SGTC_732 3970-1727 52.7 µM 1.1208075571715 0.147672950724809 no 559 0.131184893333998 683 1275699
SGTC_3304 9125678 46.087 µM 1.11898830458747 0.148064963285667 no 560 0.131572564256419 693 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_3102 9121669 49.47 µM 1.11813090899789 0.148249956134719 no 561 0.13175554356667 643 41905072
SGTC_2178 5812956 200 µM 1.11640591880635 0.148622610700251 no 562 0.132124210562631 670 5403383
SGTC_1660 st012960 28.1 µM 1.11314346102854 0.149329119664461 no 563 0.132823410251722 666 24207266
SGTC_2626 ethyl orsellinate 100 µM 1.11269889857487 0.149425566203357 no 564 0.132918884374092 648 75653 A natural product.
SGTC_1655 st012546 55.1 µM 1.10982411277536 0.150050246318741 no 565 0.133537413280234 658 720985 YLR208W SEC13
SGTC_1791 st048313 56.1 µM 1.10896771962836 0.150236673432754 no 566 0.133722053907212 636 1204976
SGTC_964 1287-0107 19.4 µM 1.10842552261713 0.15035478336985 no 567 0.133839043712359 748 51516812 YPR165W RHO1
SGTC_2951 9072950 58.06 µM 1.1051782579821 0.151063448588529 no 568 0.134541177961368 753 16488155
SGTC_2504 purpurogallin 52.29 µM 1.10504990329498 0.151091505599083 no 569 0.134568983085536 672 5281571 An antioxidant.
SGTC_2434 5670830 169.91 µM 1.10355831615442 0.151417805418732 no 570 0.13489239077726 696 1549830
SGTC_3051 9093778 49.47 µM 1.10351440946899 0.151427417546054 no 571 0.134901918748475 630 17217378
SGTC_3143 9086658 49.47 µM 1.10167276101522 0.151830959839545 no 572 0.135301981549954 788 25236626
SGTC_3281 9140613 49.47 µM 1.10042431399217 0.152104925750204 no 573 0.135573644791302 646 16013766
SGTC_2603 homopterocarpin 100 µM 1.0936831335725 0.153589915761463 no 574 0.137046987044739 716 101795 A weak amylase inhibitor.
SGTC_661 1304-0007 33.6 µM 1.09000350638627 0.154404524222413 no 575 0.137855799749247 702 3117130
SGTC_2371 9071574 200 µM 1.08724737345678 0.155016554062979 no 576 0.138463749793718 666 45596039
SGTC_2838 9002687 71.43 µM 1.08680394380667 0.155115171928814 no 577 0.138561732230085 668 6457060
SGTC_1436 4092-1007 8.32 µM 1.08639157531319 0.155206919018608 no 578 0.138652893622056 695 2881121
SGTC_600 1495-0418 41.6 µM 1.08619177710676 0.155251384625511 no 579 0.138697077260673 689 5377768
SGTC_979 1426-2828 121 µM 1.08386889689622 0.155768964718669 no 580 0.139211465986364 765 747872
SGTC_423 5-fluorouracil 457 µM 1.08176127133017 0.156239565551539 no 581 0.139679309802585 688 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1040 k898-0338 155 µM 1.08147875409465 0.15630271848273 no 582 0.139742103210649 785 20969351
SGTC_2694 st077685 81.9 µM 1.07950562718608 0.156744253230277 no 583 0.140181193311677 695 2838096
SGTC_3300 9124615 50.48 µM 1.07844645139919 0.156981607631619 no 584 0.140417283326938 711 24824903
SGTC_1094 duloxetine 25.4 µM 1.07838992000816 0.156994282591481 no 585 0.140429891744513 715 60834 A selective serotonin reuptake inhibitor.
SGTC_3169 9102970 49.47 µM 1.07716643830953 0.15726876559553 no 586 0.140702958010888 724 17027839
SGTC_105 0111-0055 734.78 µM 1.07082822165914 0.15869576607423 no 587 0.142123337433195 642 5179370
SGTC_155 k072-0202 43.6 µM 1.06878495383977 0.159157595842648 no 588 0.142583290337265 704 5857737
SGTC_2262 9014885 67.46 µM 1.06669028239171 0.159631957067012 no 589 0.14305585834826 674 6457424
SGTC_1484 3473-2379 286 µM 1.0650949194359 0.159993864486384 no 590 0.143416489072671 862 671917
SGTC_3259 9138485 49.47 µM 1.05938024828475 0.161294635090334 no 591 0.144713320665639 809 17646153
SGTC_31 0508-1974 57.237 µM 1.05932071069105 0.161308223214963 no 592 0.144726872984786 723 6810525
SGTC_699 0375-0592 111 µM 1.0582750812668 0.161546986455249 no 593 0.144965025022343 777 762578
SGTC_347 4534-1311 26.2 µM 1.05410634160574 0.162501182472889 no 594 0.145917116547985 739 2862016
SGTC_1347 1493-0251 600 nM 1.05406221812216 0.162511301611769 no 595 0.145927216258691 808 3986378
SGTC_3059 1327-0034 3 µM 1.05327368049353 0.162692211453912 no 596 0.146107788968846 734 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_106 0092-0003 11.579 µM 1.05196748915019 0.162992171846062 no 597 0.146407232913444 674 1072148
SGTC_3098 9119039 49.47 µM 1.05160910249638 0.163074536387418 no 598 0.146489464919957 745 17161528
SGTC_232 clozapine 119 µM 1.04901885937054 0.163670631115109 no 599 0.147084719266646 744 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2483 5729050 27.16 µM 1.04864261911285 0.163757333099456 no 600 0.147171316375515 851 2865180
SGTC_1138 3761-0006 1.03 µM 1.04829822495965 0.163836722496979 no 601 0.147250613601756 756 12061087
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.04794296037885 0.163918643903787 no 602 0.147332443762494 747 390807
SGTC_2288 7946289 167.31 µM 1.04504747254055 0.164587313075976 no 603 0.148000514636987 820 1246052
SGTC_2377 9073351 62.6 µM 1.04432783502459 0.164753776356578 no 604 0.148166869453639 720 7337946 YHR072W ERG7
SGTC_1570 verbenone 133 µM 1.04409084976605 0.164808618573773 no 605 0.14822167946304 797 29025 A natural terpanoid with antifungal properties.
SGTC_391 gliotoxin 8.33 µM 1.04361532244342 0.164918698942742 no 606 0.14833170045418 806 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1917 st066507 28.5 µM 1.04345637550823 0.164955504367531 no 607 0.148368487594577 775 3156428
SGTC_1728 st035614 33.7865 µM 1.04331913556073 0.16498728764561 no 608 0.148400255715433 818 15945546
SGTC_245 methotrexate 289.6 µM 1.0422441280757 0.165236384845931 no 609 0.148649254398741 803 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2276 7947513 42.08 µM 1.0403373176289 0.165678823125254 no 610 0.149091606200395 678 2105100
SGTC_2081 5214970 32.255 µM 1.03873677585384 0.166050788511146 no 611 0.149463586278721 759 2063512
SGTC_781 4335-2806 94.4 µM 1.03810361908897 0.166198082767583 no 612 0.149610908366051 856 845254
SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.0379426089979 0.1662355527631 no 613 0.149648387431212 814 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2233 sulbentine 40.3845 µM 1.03577609578091 0.166740270648097 no 614 0.150153305999289 836 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_3211 9128781 49.47 µM 1.03544229262178 0.166818122321534 no 615 0.150231201620498 722 17194361
SGTC_532 1548-0774 215 µM 1.03357407044068 0.167254273668842 no 616 0.150667663238667 800 5932993
SGTC_2406 ethylparaben 405.7 µM 1.03315610177751 0.167351952308788 no 617 0.15076542624312 657 8434 A possible steroid mimic.
SGTC_458 nppb 133 µM 1.03303929941247 0.167379255414442 no 618 0.150792753902575 742 4549 A chloride channel blocker.
SGTC_2737 bleomycin 30.5 nM 1.03194676096848 0.167634780432943 no 619 0.151048529287512 820 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_397 arbidol 50 µM 1.03153013352237 0.167732288209845 no 620 0.151146142393138 816 131410 A RNA synthesis inhibitor.
SGTC_109 0132-0036 33.701 µM 1.03124324669684 0.167799452631084 no 621 0.151213382507988 644 67274 A color developer.
SGTC_2070 5230947 200 µM 1.03068421923831 0.167930378912423 no 622 0.151344463704387 814 2835538
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.02739536622762 0.16870197130214 no 623 0.152117166273542 761 7104
SGTC_2423 st077119 87.2 µM 1.0262804065623 0.168964066486851 no 624 0.152379715069937 760 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2105 5350118 200 µM 1.0245551194738 0.169370147441129 no 625 0.152786575182488 785 2133313
SGTC_1689 st020265 53.493 µM 1.02375609854409 0.169558425105051 no 626 0.152975245521236 788 5758320 YPR016C TIF6
SGTC_65 0798-0905 34.986 µM 1.0217654054634 0.170028086751273 no 627 0.153445973240119 863 3602145
SGTC_2705 st078069 42.8 µM 1.0190833718176 0.170662172653251 no 628 0.154081693816508 722 1530061
SGTC_808 0711-0032 135 µM 1.01760995838841 0.171011160168262 no 629 0.154431676456634 796 4252555
SGTC_2796 7949634 45.45 µM 1.01567601635095 0.171469919184729 no 630 0.154891846322719 736 2971588
SGTC_2734 clemastine 41.6 µM 1.01009553644268 0.17279809407155 no 631 0.156224760265685 675 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2922 7999257 32.47 µM 1.00959255535719 0.172918126723231 no 632 0.156345268915672 720 2988377
SGTC_3286 9117135 37.221 µM 1.00597940185342 0.173781939678488 no 633 0.157212739326531 748 3438150
SGTC_1153 4055-0057 267 µM 1.00419485066596 0.174209591246819 no 634 0.157642351822174 807 882706
SGTC_2496 diffractaic acid 79.83 µM 1.00419026058037 0.174210692080985 no 635 0.157643457832007 835 94870 An apoptosis inducer which activates caspases.
SGTC_2237 6667747 47.222 µM 1.0037890563243 0.174306929447938 no 636 0.157740150203804 759 729940 YDL015C TSC13
SGTC_183 3914-0051 30.55 µM 1.00196944943179 0.174743824732672 no 637 0.158179174094922 812 1596232
SGTC_2783 7738165 71.43 µM 0.99735425869588 0.175855065907552 no 638 0.159296292761846 690 17201110
SGTC_1813 st051246 8.6015 µM 0.993265153908575 0.176843367549888 no 639 0.160290377150619 796 5291959
SGTC_1919 st067113 52.3 µM 0.992866599270241 0.176939882203122 no 640 0.160387484411312 791 1268243
SGTC_1701 st028638 40.4 µM 0.992493375770013 0.177030292800478 no 641 0.160478454624417 837 3490878
SGTC_1381 2324-0066 62.1 µM 0.991045604843524 0.177381280611714 no 642 0.160831656035868 761 10885928
SGTC_1613 st002381 52.1 µM 0.990547512045516 0.177502136377642 no 643 0.160953289114108 824 551167
SGTC_2585 alliin 100 µM 0.98776604738018 0.178177977909748 no 644 0.161633619688187 816 87310 A garlic compound which reacts with lipids.
SGTC_3023 9089636 49.47 µM 0.986768111537507 0.178420851647251 no 645 0.161878165414472 867 17249241
SGTC_2658 polymyxin b sulfate 77.05 µM 0.984713683465053 0.178921506634101 no 646 0.162382364742128 825 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_486 niguldipine 82 µM 0.984579413911171 0.178954258278322 no 647 0.162415352826921 773 1236 A calcium channel blocker.
SGTC_276 colchicine 750 µM 0.984033605729544 0.179087433144251 no 648 0.1625494948902 839 2833 A microtubule depolymerizer.
SGTC_1054 3429-0080 167 µM 0.982853147284048 0.179375673146146 no 649 0.162839860015162 848 1162877
SGTC_1446 4239-0190 62 µM 0.979429425330525 0.180213313605353 no 650 0.163683921942477 852 1340085
SGTC_3135 9127742 49.47 µM 0.977428810648777 0.180703914247193 no 651 0.164178452747002 762 3643468
SGTC_541 4513-1321 94 µM 0.97544820221198 0.181190432899599 no 652 0.164668991728367 782 747515
SGTC_1062 mesoridazine 14.2 µM 0.975312607672299 0.181223770458922 no 653 0.164702609239855 836 4078 A neuroleptic.
SGTC_2193 5925765 200 µM 0.974601064559906 0.181398774915611 no 654 0.16487909268186 800 877370
SGTC_2533 agelasine 13.65 µM 0.970284217067922 0.182462773005941 no 655 0.165952421075188 859 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_356 1634-0012 32.5 µM 0.970032282355263 0.182524988960506 no 656 0.166015200533881 862 735457
SGTC_702 1488-0190 94 µM 0.969941597205142 0.18254738714488 no 657 0.166037802067282 836 949357
SGTC_1786 berberine 21.6 µM 0.967983148242538 0.183031520193518 no 658 0.16652639295579 787 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_287 k060-0039 29.6 µM 0.96768006368533 0.183106514903809 no 659 0.166602088877988 845 5861974
SGTC_3011 9081274 71.4286 µM 0.967179218007074 0.183230485282135 no 660 0.16672722466419 863 6625322
SGTC_2907 7721985 69.9 µM 0.964810547287386 0.183817492563219 no 661 0.167319856048161 822 3267881
SGTC_1668 st014914 51.6 µM 0.963185441510113 0.184220905276373 no 662 0.167727234894454 854 2839556
SGTC_1374 2889-5571 141 µM 0.962574677698135 0.184372662297426 no 663 0.167880505157116 852 2853281
SGTC_2505 galangin 7.89 µM 0.960653839381804 0.184850441425067 no 664 0.168363124125471 761 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2225 6654152 15.4 µM 0.960635762954207 0.184854941311455 no 665 0.168367670140342 787 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_412 gemfibrozil 100 µM 0.960544681624804 0.184877615833553 no 666 0.168390577254317 792 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2816 7982706 58.44 µM 0.956364185619954 0.185920202047352 no 667 0.169444136150367 793 2981853
SGTC_906 1165-0455 526 µM 0.952271163775667 0.186944497515514 no 668 0.170479739110057 827 3252859
SGTC_2058 5236698 133 µM 0.950023952907034 0.187508353099267 no 669 0.171050040924759 822 766665
SGTC_469 w7 172 µM 0.948484725310355 0.187895171927949 no 670 0.171441372635682 839 45115570 A P450 inhibitor.
SGTC_277 nystatin 15.5 µM 0.947350258733447 0.1881805866121 no 671 0.171730164292846 887 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1419 3993-2473 62.6 µM 0.946592520676835 0.188371371024945 no 672 0.171923228306723 872 704026
SGTC_1847 st056231 15 µM 0.94521996659624 0.188717258394125 no 673 0.172273293961948 901 5393180
SGTC_488 nitrendipine 139 µM 0.944984082505217 0.188776741223744 no 674 0.172333501230963 895 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_475 α-linolenic acid 10 µM 0.944467011457626 0.188907171314561 no 675 0.172465525871237 910 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1645 Cervolide 78 µM 0.944305389493272 0.188947951504416 no 676 0.172506806315106 819 23173 A fragrance.
SGTC_1173 0443-0020 122 µM 0.943091527997154 0.189254404355011 no 677 0.172817044377449 848 5331295
SGTC_1016 4226-1401 38 µM 0.941616259571631 0.189627263979836 no 678 0.173194571065003 851 2901613
SGTC_3187 9109394 49.47 µM 0.940352913281623 0.189946921283617 no 679 0.173518283225863 856 17098090
SGTC_1695 st026914 34.495 µM 0.937469731384494 0.190677676012039 no 680 0.174258493262204 864 3289191
SGTC_1334 1486-0610 236 µM 0.937013244397356 0.190793532603714 no 681 0.174375872595629 859 3742339
SGTC_14 0354-0009 295 µM 0.935566077139293 0.191161109711697 no 682 0.174748323638665 893 1713507
SGTC_1133 3473-0247 50 µM 0.93371517806141 0.191631866049506 no 683 0.175225416755548 827 711311
SGTC_366 0181-0206 4.31 µM 0.933575056413935 0.191667533377078 no 684 0.175261568522295 910 274874
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.932623247520577 0.19190991959123 no 685 0.175507262979625 832 689007
SGTC_21 0849-0113 22.993 µM 0.930784620112495 0.192378672667478 no 686 0.175982493473416 871 1560156
SGTC_424 splitomicin 100 mM 0.92820654483971 0.193037123901679 no 687 0.176650220062121 797 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1058 3448-5425 97.3 µM 0.927170370090374 0.193302154505688 no 688 0.176919042104736 856 7279705
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.926425781952976 0.193492740744615 no 689 0.177112375349447 870 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_923 1900-2434 73.3 µM 0.926187975596558 0.193553634267903 no 690 0.177174150177203 858 5910570
SGTC_1259 0671-0132 43 µM 0.925859810097323 0.193637684659087 no 691 0.177259419895839 840 X1259
SGTC_2120 5538279 151.968 µM 0.925639613534875 0.193694094310119 no 692 0.177316649757271 881 2058197
SGTC_3122 9126309 49.47 µM 0.924519977587662 0.193981076069396 no 693 0.177607827537572 949 17591206
SGTC_3280 9140961 49.47 µM 0.923350121149176 0.194281206820943 no 694 0.177912388048248 845 4901226
SGTC_895 0964-0006 13.7 µM 0.923174314802187 0.194326334980988 no 695 0.177958185937008 881 6738897
SGTC_3272 9137413 49.47 µM 0.922335130463553 0.194541835189083 no 696 0.178176897482559 872 17614870
SGTC_872 0588-0139 234 µM 0.921111000882668 0.194856448963381 no 697 0.178496238667567 911 2047100
SGTC_51 1013-0126 23.419 µM 0.92025030097895 0.195077842767525 no 698 0.178720986927567 866 1627850
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.91684658192779 0.195954862439533 no 699 0.179611519538593 854 6708514
SGTC_2476 5806916 10.51 µM 0.914043201959685 0.196678989056754 no 700 0.180347072715884 865 2870194
SGTC_1213 1315-0166 115 µM 0.913198636941071 0.196897461601232 no 701 0.180569040353247 775 768401
SGTC_2675 theaflavin digallate 100 µM 0.912372001380753 0.197111438361705 no 702 0.180786461635369 913 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_3192 9110362 49.47 µM 0.911206611143618 0.197413341571331 no 703 0.18109326065228 924 16649480
SGTC_1562 morin hydrate 59.1 µM 0.910646163240583 0.197558629386342 no 704 0.181240919468108 865 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.909403391349527 0.197881030094587 no 705 0.181568616162358 1098 16725076
SGTC_3268 9137683 49.47 µM 0.908971292267261 0.19799319994922 no 706 0.181682639777035 885 1953228
SGTC_489 paxilline 115 µM 0.906976653057195 0.198511491721525 no 707 0.182209571791841 852 105008 A toxic potassium channel blocker.
SGTC_3241 9133421 49.47 µM 0.906307222527206 0.198685621407421 no 708 0.182386631862548 917 17018221
SGTC_2882 9058044 58.44 µM 0.905351139850549 0.198934473593737 no 709 0.182639695907396 897 18076804
SGTC_2072 5231554 129 µM 0.904465161452544 0.199165246428189 no 710 0.182874399790839 1005 789545
SGTC_3072 9116419 49.47 µM 0.903147858150384 0.199508665429939 no 711 0.183223713473593 844 17170162
SGTC_2137 5261020 140 µM 0.902434941978735 0.199694670160141 no 712 0.183412933244593 890 763655
SGTC_2924 9010168 62.78 µM 0.902101362512826 0.199781739155428 no 713 0.183501512586776 902 2993929
SGTC_1897 st060201 15 µM 0.899261835214871 0.200523820379077 no 714 0.184256605348588 848 611878
SGTC_1464 k208-0027 110 µM 0.898764434404245 0.200653981128965 no 715 0.184389073906387 938 X1464
SGTC_1762 st045503 25.4615 µM 0.897362416680583 0.201021136563503 no 716 0.184762780209086 923 4645554
SGTC_1180 1193-0155 285 µM 0.895796982857539 0.201431562661433 no 717 0.185180600801455 873 2921347
SGTC_1839 st053978 48 µM 0.895006462741759 0.20163901225129 no 718 0.185391816618908 919 3788398
SGTC_1123 mangostin 811.285 nM 0.894638982905601 0.201735490472531 no 719 0.185490052944622 859 5281650 An antioxidant.
SGTC_1373 2887-0003 58.5 µM 0.893560237802554 0.202018864053117 no 720 0.185778614406694 879 776948
SGTC_1682 st012968 530 nM 0.8934821322041 0.202039390714948 no 721 0.185799518252464 817 24207270
SGTC_2656 pseudo-anisatin 100 µM 0.8918986062733 0.202455820812673 no 722 0.186223640884272 935 6708809 A neurotoxin.
SGTC_1035 k081-0041 55.2 µM 0.891268772159159 0.202621594930933 no 723 0.186392498728037 965 731709
SGTC_2558 carylophyllene oxide 100 µM 0.890601781018851 0.202797237303436 no 724 0.186571421700603 979 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2803 7707263 71.43 µM 0.889914616084021 0.202978287249766 no 725 0.186755867560088 873 2199229
SGTC_1136 pergolide 1.05886 µM 0.889740337009336 0.203024220557934 no 726 0.1868026647375 928 47811 A dopamine receptor agonist.
SGTC_3066 9117245 49.47 µM 0.889422035206623 0.203108128775634 no 727 0.1868881534304 958 17176980
SGTC_2196 6573537 42.6665 µM 0.888339479174244 0.203393658592029 no 728 0.187179084736224 937 2903087
SGTC_1363 1636-0063 10.4 µM 0.884900367867891 0.204302329759672 no 729 0.188105184803484 958 6072185
SGTC_79 0052-0007 94.094 µM 0.884388687138755 0.204437730691076 no 730 0.188243213878161 934 2801472
SGTC_2350 9023895 38.85 µM 0.884302560709567 0.204460526713597 no 731 0.188266453163937 904 2997209
SGTC_2972 9093619 59.92 µM 0.880353483101681 0.205507396429254 no 732 0.189333923831872 883 25236256
SGTC_1920 st075728 45.7 µM 0.877811419471695 0.206182958219209 no 733 0.190023033143107 917 3400306
SGTC_179 1273-0063 6.77 µM 0.877783916556852 0.206190274401125 no 734 0.190030497125369 893 3108139
SGTC_1279 0874-0590 65.2 µM 0.877451591469155 0.20627868995151 no 735 0.190120700665539 940 3523074
SGTC_2936 9038235 15.59 µM 0.876853638176102 0.20643783283395 no 736 0.19028307035258 942 4749415
SGTC_1147 3809-1045 12.3 µM 0.876569397275115 0.206513507916783 no 737 0.190360283677512 907 325925
SGTC_283 0987-0079 11.7 µM 0.875446778652419 0.206812549680471 no 738 0.19066542824643 974 411556
SGTC_1942 st076330 65.2 µM 0.873445377423822 0.207346315899115 no 739 0.191210183318358 980 24208414
SGTC_1037 k284-1091 78.7 µM 0.873047008955278 0.20745265639248 no 740 0.191318727727015 892 3334711
SGTC_2401 5128683 200 µM 0.871532012034173 0.207857364043696 no 741 0.191731867361786 885 708373
SGTC_1508 1080-0625 72.9 µM 0.86964878967194 0.208361086796856 no 742 0.192246183030813 907 767111
SGTC_731 3966-0296 387 µM 0.867794802860818 0.208857692322672 no 743 0.192753337831793 940 660956
SGTC_1759 st043059 70 µM 0.867042232494154 0.209059473267915 no 744 0.192959435159398 945 669426
SGTC_747 3448-8087 38.7 µM 0.865926075239336 0.209358951290368 no 745 0.193265351326824 941 5168703
SGTC_3092 9117248 49.47 µM 0.864900694385952 0.209634295314079 no 746 0.193546648222367 1017 17141857
SGTC_96 0929-0093 37.281 µM 0.86484439479353 0.209649419526563 no 747 0.193562100346887 907 6991579
SGTC_2597 laccaic acid a 100 µM 0.864679139298134 0.209693817145868 no 748 0.193607461121799 927 5491415 A textile dye.
SGTC_514 4466-0038 2.65 nM 0.86365303710928 0.209969613959381 no 749 0.193889259702169 964 5722064
SGTC_373 0844-0104 25.9 µM 0.8634884006237 0.210013884961263 no 750 0.193934497103105 1000 5375804
SGTC_764 1951-2361 146 µM 0.862775646586546 0.210205608868817 no 751 0.194130415730815 897 5438930
SGTC_438 sphingosine 6.67 µM 0.862425740021314 0.210299767941177 no 752 0.194226640581728 907 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.862388732260316 0.210309728094718 no 753 0.194236819471991 976 4174840
SGTC_1975 st070967 30.8 µM 0.862264044222201 0.2103432882837 no 754 0.194271116989972 1026 261391
SGTC_3249 9135183 49.47 µM 0.860564602411447 0.210801011937976 no 755 0.194738944306971 989 4902779
SGTC_1879 gemcitabine 100 µM 0.86010662351247 0.210924462750806 no 756 0.194865135213567 948 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2234 tolnaftate 200 µM 0.860053886904442 0.210938680924091 no 757 0.19487966938181 953 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2090 5301565 104.445 µM 0.860027667697678 0.210945750022166 no 758 0.194886895620196 986 2056344
SGTC_1983 st071813 46.9 µM 0.859986331975587 0.210956895045451 no 759 0.19489828843088 937 11838595
SGTC_1197 1601-0112 267 µM 0.859655892209781 0.211046001311638 no 760 0.194989377670774 960 7350313
SGTC_3172 9105863 49.47 µM 0.858706217935857 0.211302212911674 no 761 0.195251309550919 939 2348785
SGTC_2884 9058502 51.95 µM 0.858462847960411 0.211367900754283 no 762 0.195318468392553 948 6471554
SGTC_371 0195-0006 7.36 µM 0.858416640845527 0.211380373839562 no 763 0.195331221001289 857 3928593
SGTC_1733 st037357 54.9 µM 0.857990743679957 0.21149536023471 no 764 0.195448787321049 940 1272339 YGL099W LSG1
SGTC_2673 kobusone 100 µM 0.855795734145524 0.212088563254789 no 765 0.196055387609762 998 6710676 An epoxy ketone and protein crosslinker.
SGTC_1353 1498-1206 8.11 µM 0.854334298684713 0.212484056250276 no 766 0.196459894097688 990 6756808
SGTC_369 0957-0393 4.5 µM 0.851466531294621 0.213261381125066 no 767 0.197255123721246 936 6997992
SGTC_1578 josamycin 24.2 µM 0.847474513261661 0.214346196636318 no 768 0.198365343587637 896 5282165 A P450 substrate.
SGTC_510 ag-490 170 µM 0.843326192655762 0.215476879883714 no 769 0.199523018911145 1081 5328779
SGTC_2286 7945697 125 µM 0.842447512269955 0.215716819852725 no 770 0.199768753870684 988 1245733
SGTC_2688 kanamycin b 96.69 µM 0.84221075869065 0.215781496285774 no 771 0.199834996362697 1230 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_11 0438-0307 1.3 µM 0.84052486602385 0.216242373956363 no 772 0.200307082757869 981 4011476
SGTC_1244 0416-0015 52.5 µM 0.838077033496994 0.216912558950985 no 773 0.200993720315164 957 96201
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.837955185275871 0.216945950763952 no 774 0.201027936615477 938 279621
SGTC_524 r073-0010 27.8 µM 0.83712424864087 0.217173743433006 no 775 0.201261365766637 940 2772106
SGTC_1066 ketoconazole 628 nM 0.836230766265132 0.217418836463133 no 776 0.201512546677649 1032 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2781 5567276 71.43 µM 0.83564866387676 0.21757860006873 no 777 0.20167629165743 964 2853274
SGTC_1690 st023502 41.2 µM 0.834197443421817 0.217977196375835 no 778 0.202084865785505 971 24207482
SGTC_2421 5690543 90.72 µM 0.832769306772856 0.218369863128958 no 779 0.202487424114629 976 3397993
SGTC_12 0849-0099 9.267 µM 0.82861077570082 0.219515570757636 no 780 0.203662344249993 964 6071388
SGTC_2222 6885208 172.143 µM 0.827633457569477 0.219785329739682 no 781 0.203939057163088 962 609514
SGTC_594 1487-1584 10.8 µM 0.827374326903499 0.219856886792703 no 782 0.204012463668142 1031 5013332
SGTC_2382 9035899 200 µM 0.8273251303929 0.219870473562225 no 783 0.204026401827805 1001 6462679
SGTC_2792 7535235 81.82 µM 0.827318570741868 0.21987228520002 no 784 0.204028260324904 929 1281891
SGTC_2459 5811157 9.22 µM 0.826078669502326 0.220214873692801 no 785 0.204379733415413 1028 2870684 YBR192W RIM2
SGTC_1764 st044502 93.5 µM 0.825365932024012 0.220411943703586 no 786 0.204581935165258 1000 8407
SGTC_1951 sophoraflavanone G 9.2 µM 0.824107874020545 0.22076003994642 no 787 0.204939133258165 1004 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_3121 9125696 49.47 µM 0.823065610874782 0.221048665500067 no 788 0.205235341764791 1039 1235365
SGTC_861 0443-0273 110 µM 0.821684735054602 0.221431392721641 no 789 0.205628174616497 1025 6149169
SGTC_2678 equilin 100 µM 0.821467920937014 0.221491519895113 no 790 0.205689894616051 1047 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2712 st079126 47.7 µM 0.820188635132612 0.221846483048478 no 791 0.206054289873064 974 3152970
SGTC_1730 st033808 45.1 µM 0.819895567935024 0.221927846058602 no 792 0.206137821795841 1061 1045166
SGTC_730 1436-0052 41.2 µM 0.819449191152116 0.222051804499146 no 793 0.206265089587124 1006 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1963 st076565 50.3 µM 0.818358005139832 0.222354992247959 no 794 0.206576396837333 1012 4914280
SGTC_2731 amoxapine 43.43 µM 0.817762138447003 0.222520654381343 no 795 0.206746510580992 1013 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2336 9001819 198.65 µM 0.815627837450725 0.223114607317225 no 796 0.207356511535396 1036 2989602
SGTC_1870 st057514 26.5 µM 0.81511685598108 0.223256941758021 no 797 0.207502712004781 1009 5393161
SGTC_7 0192-1582 4.227 µM 0.813270538144884 0.223771666117794 no 798 0.208031482402366 1077 252616
SGTC_3070 9117005 49.47 µM 0.812516962966705 0.223981944720357 no 799 0.20824752856894 1006 8779016
SGTC_2947 9072639 7.68 µM 0.810856530558216 0.224445669943303 no 800 0.208724033024972 1090 16488146
SGTC_575 k072-0246 11.9 µM 0.806901054966872 0.225552546467667 no 801 0.209861745488331 1043 6796779
SGTC_9 0092-0002 10.449 µM 0.80607537885031 0.225783987838997 no 802 0.210099693549812 1019 759368
SGTC_2445 5742597 35.57 µM 0.803647384288419 0.226465345224583 no 803 0.210800324559179 990 1774255
SGTC_3355 9151058 44.0485 µM 0.802840627321695 0.22669199858619 no 804 0.211033428268095 1072 17015728
SGTC_2598 perillyl alcohol 100 µM 0.802501657622585 0.226787268198826 no 805 0.211131414963065 1038 10819 An apoptosis inducer.
SGTC_2259 7964009 200 µM 0.800610737062044 0.227319137871428 no 806 0.211678516441472 971 313134
SGTC_584 0986-0246 15.4 µM 0.799882628375509 0.227524124288521 no 807 0.211889401747845 1163 53315 YDR232W HEM1
SGTC_2177 5811945 192 µM 0.795348973900096 0.228802835868539 no 808 0.213205266444914 1067 5343475
SGTC_3027 9089541 49.47 µM 0.793620935425495 0.229291286767888 no 809 0.213708070460849 1059 9943819
SGTC_508 roscovitine 141 µM 0.792780097019291 0.229529171156327 no 810 0.213952977185683 1078 160355 A CDKinase inhibitor.
SGTC_1139 k015-0024 46.9 µM 0.79088552061398 0.230065678554423 no 811 0.214505399254851 1073 2766652
SGTC_331 k048-0133 24.5 µM 0.788726522525338 0.230677919575303 no 812 0.215135931416017 1045 6813582
SGTC_2079 5212404 121 µM 0.788186963502638 0.230831067851539 no 813 0.215293676703195 1074 758462
SGTC_3204 9114183 49.47 µM 0.788176073560402 0.23083415943405 no 814 0.215296861173756 1010 17027248
SGTC_447 ml7 120 µM 0.787853072952658 0.230925867682012 no 815 0.215391326437367 1086 4216 Selective myosin light chain kinase inhibitor.
SGTC_3134 9127454 49.47 µM 0.786740060510924 0.231242036544355 no 816 0.215717023936869 1093 24262820
SGTC_2174 5790901 200 µM 0.78667337635777 0.231260986901841 no 817 0.215736546581933 1038 786020
SGTC_103 0844-0104 51.839 µM 0.78439727476655 0.231908330517398 no 818 0.216403518498141 1130 5375804
SGTC_1781 st038725 66.3 µM 0.784279165555642 0.231941949351149 no 819 0.216438160884007 1078 4270275 YIL048W NEO1
SGTC_2335 9018011 154.17 µM 0.78379752915596 0.232079071361046 no 820 0.216579461955093 1093 6458208
SGTC_1681 tripelennamine 100 µM 0.782520700897287 0.232442803003783 no 821 0.216954312237627 1032 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_3113 9123498 49.47 µM 0.782408301933637 0.232474837411612 no 822 0.216987328189535 1134 8897275
SGTC_1142 3253-1408 9.78 µM 0.781561942598501 0.232716133948743 no 823 0.217236030117992 1050 256655
SGTC_196 k015-0023 18.111 µM 0.781023094887787 0.232869831598469 no 824 0.217394455776648 1070 5211998
SGTC_1731 st035964 63 µM 0.779647344239311 0.233262498034888 no 825 0.217799240223655 1005 6739575
SGTC_1445 4239-0156 97.7 µM 0.777566900194357 0.233856995288354 no 826 0.21841219030758 1131 4008346
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.776772643743609 0.2340841792868 no 827 0.218646459634696 1062 364106
SGTC_234 nsc-17383 10.7 µM 0.77627050507109 0.23422787083735 no 828 0.218794642176819 1117 408974
SGTC_878 0828-0289 13.7 µM 0.774162667042644 0.234831580253988 no 829 0.219417301219143 1046 745350 YLR208W SEC13
SGTC_395 anisomycin 6.25 µM 0.773491491173318 0.235023993237027 no 830 0.21961578124865 996 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2314 7727897 200 µM 0.773479947453018 0.235027303357388 no 831 0.219619195857611 1083 900724
SGTC_1483 3453-0561 55.9 µM 0.773018528762374 0.235159634598471 no 832 0.219755707530218 1063 4546991
SGTC_518 1021-0119 62.6 µM 0.772022385682807 0.235445460834107 no 833 0.220050584560568 996 1097762
SGTC_2037 5169046 200 µM 0.771440377397017 0.235612546856389 no 834 0.22022297492792 1063 5718022
SGTC_484 loperamide 105 µM 0.77023855938207 0.235957778027391 no 835 0.220579197380007 1026 3955 An opioid-receptor agonist.
SGTC_675 1309-0189 238 µM 0.769324695694028 0.236220478654145 no 836 0.220850290125898 1077 4246530
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.768634950057757 0.236418860588052 no 837 0.22105502571989 1049 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1647 st011722 22.4 µM 0.767875661246057 0.23663735025966 no 838 0.22128052919527 1054 2854783
SGTC_402 epigallocatechin gallate 10 µM 0.765924974271209 0.237199180471524 no 839 0.221860472435522 1066 65064 An antioxidant.
SGTC_1208 2323-2347 50.3 µM 0.765904234711247 0.237205157743005 no 840 0.221866643009506 1095 5412760
SGTC_1534 6-azauridine 81.6 µM 0.765863369474132 0.237216935603217 no 841 0.221878801797754 1147 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_565 1418-0001 44.5 µM 0.765328466687156 0.237371130734073 no 842 0.222037988530159 1113 2862145
SGTC_2139 5578692 56.4705 µM 0.76426680964129 0.237677334986356 no 843 0.222354130046844 1061 650991 YMR113W FOL3
SGTC_3038 9091290 49.47 µM 0.761557687256445 0.238459684094631 no 844 0.223162018347948 1087 25236843
SGTC_1343 1487-0095 224 µM 0.75938926278862 0.23908690325074 no 845 0.223809867294633 1098 4560101 YGL055W OLE1
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.758865990271842 0.239238395348948 no 846 0.223966362672982 1086 75037 A free radical scavenger.
SGTC_925 2064-1272 59.6 µM 0.758069084964584 0.239469207321994 no 847 0.224204812951554 1024 6815817
SGTC_3333 9141820 12.094 µM 0.757560655696261 0.239616529940398 no 848 0.224357020627966 1033 1939433
SGTC_3327 9140648 26.9345 µM 0.756955405664361 0.239791971852329 no 849 0.224538289832884 1093 8029710
SGTC_363 0455-0021 3.06 µM 0.755491485230309 0.240216603435689 no 850 0.224977069690304 1110 4597466
SGTC_2282 7944268 200 µM 0.755091504353195 0.240332694990333 no 851 0.225097040154601 1106 2970414
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.753292505405596 0.240855219113126 no 852 0.225637080725211 1054 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_3141 9094609 49.47 µM 0.753084127760351 0.240915782880702 no 853 0.225699680844365 1047 25236309 YDL196W YDL196W
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.751673019850479 0.241326131207022 no 854 0.226123859658655 1156 688751
SGTC_950 1165-0508 94.1 µM 0.751633211187832 0.24133771301921 no 855 0.226135832666941 1079 6148369
SGTC_1676 st018489 23.4 µM 0.751243012771792 0.24145125215532 no 856 0.22625320922537 1072 3696235
SGTC_1571 st070080 73.4 µM 0.750872912399282 0.241558970008782 no 857 0.226364571840361 1113 4315245
SGTC_3031 9088762 49.47 µM 0.749268767881635 0.242026158402701 no 858 0.226847614112576 1112 205253
SGTC_2683 piperine 63.03 µM 0.743851336967193 0.243607537592508 no 859 0.228483209143803 1080 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_970 1315-0089 19.5 µM 0.74287060687351 0.243894413668887 no 860 0.228780011357385 1101 6811083 YLR033W RSC58
SGTC_2754 granisetron 64.02 µM 0.74273285231599 0.243934723232108 no 861 0.228821717890862 1114 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_888 0916-0002 6.97 µM 0.742613639511691 0.243969610032287 no 862 0.228857814172522 1139 2802138 YIL048W NEO1
SGTC_304 1310-0298 97 µM 0.741520553483885 0.244289619534128 no 863 0.229188937153336 1095 1550234
SGTC_1649 st011737 51.3 µM 0.740342502979031 0.244634756216385 no 864 0.229546098600546 1094 1761035
SGTC_1708 st033234 31.827 µM 0.739556760155876 0.244865103344423 no 865 0.229784493435241 1173 674664
SGTC_1780 st038448 24.544 µM 0.738777809821461 0.245093574368051 no 866 0.230020964205191 1117 728868 YDL195W SEC31
SGTC_770 0389-1121 67.2 µM 0.738114619141107 0.245288182686234 no 867 0.230222400384617 1167 6753108
SGTC_1774 st048371 48.465 µM 0.736579261260728 0.245739040488573 no 868 0.230689125257394 1134 4242727
SGTC_3210 9128157 49.47 µM 0.736479975724557 0.245768210992559 no 869 0.23071932469886 1051 17590849
SGTC_1338 1486-1223 76 µM 0.736326389969134 0.245813338788919 no 870 0.230766044856879 1142 3444526
SGTC_2732 terfenadine 20 µM 0.736217610532759 0.24584530392456 no 871 0.230799138312585 1126 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2263 7948595 193.29 µM 0.735482188274664 0.246061468289674 no 872 0.231022941884108 1059 2971371
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.735440626377108 0.24607368771749 no 873 0.231035593608853 1096 688662
SGTC_1348 1493-0373 93.8 µM 0.733715003300633 0.246581317647957 no 874 0.231561226264068 1115 3010129
SGTC_1112 tnp00069 1.16933 µM 0.731912162881489 0.247112261340659 no 875 0.232111090960285 1172 145826
SGTC_1318 1280-3875 124 µM 0.731825258610339 0.247137870435102 no 876 0.232137615033478 1120 373245
SGTC_1006 4099-6547 255 µM 0.731822164517341 0.247138782233715 no 877 0.232138559413436 1127 3146833
SGTC_1657 st012939 43.4 µM 0.731680483632966 0.247180536116916 no 878 0.232181805584613 1131 24207257
SGTC_745 0469-0705 296 µM 0.729936416401446 0.247694828119595 no 879 0.232714525642437 1224 3486736
SGTC_1399 3562-5772 25 µM 0.728214637228025 0.248203107799097 no 880 0.23324110354587 1079 23847490
SGTC_1043 0916-0009 19.3 µM 0.726595698272276 0.248681535329172 no 881 0.233736832108613 1204 3101130
SGTC_787 4152-0075 138 µM 0.726016589275608 0.248852792340496 no 882 0.233914300383989 1107 9566539
SGTC_199 4063-0024 41.6 µM 0.725069674832114 0.249132953818772 no 883 0.234204643614085 1173 306215
SGTC_3120 9124077 49.47 µM 0.724106058261297 0.249418229062405 no 884 0.234500312774408 1215 18774327 YGL155W CDC43
SGTC_1106 tegaserod maleate 11.7 µM 0.722835441926685 0.249794655725239 no 885 0.234890494984816 1157 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_3156 9099931 49.47 µM 0.722130754307838 0.250003553035405 no 886 0.235107045783128 1177 18111053
SGTC_1547 harmine 94.2 µM 0.721112452331504 0.250305581740516 no 887 0.235420165114068 1213 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2426 5582046 32.21 µM 0.721103291067297 0.250308299852289 no 888 0.235422983170302 1156 2251934
SGTC_1600 coumarin 106 71.1 µM 0.720428887256247 0.25050843583347 no 889 0.235630484684657 1174 100336 A hepatotoxic, DNA x-linker.
SGTC_374 0880-0231 82.3 µM 0.720298180106924 0.250547234275872 no 890 0.235670712511875 1139 6833587
SGTC_2969 9091408 28.7 µM 0.719777966866219 0.250701683262253 no 891 0.235830856422683 1091 4286311
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.718546911611667 0.251067378816132 no 892 0.236210066801531 1170 6312947
SGTC_3145 9085516 49.47 µM 0.717406752364114 0.251406324489968 no 893 0.236561577201211 1174 25236195
SGTC_2904 7225135 42.03 µM 0.717404761117241 0.251406916657814 no 894 0.236562191353084 1223 4446116
SGTC_2817 7995342 71.43 µM 0.717221030818738 0.251461558547319 no 895 0.236618862288933 1136 18879975
SGTC_1053 3366-3204 134 µM 0.716859359481232 0.251569138919222 no 896 0.236730440304276 1146 3632071 YPR165W RHO1
SGTC_2378 9074213 121.43 µM 0.715354090391564 0.252017147406926 no 897 0.237195136550575 1175 657714
SGTC_2277 7947813 106.88 µM 0.71493928451851 0.25214067871578 no 898 0.237323280560114 1159 1246798
SGTC_1386 3228-0095 33.8 µM 0.713061551185939 0.252700276578819 no 899 0.237903835100387 1145 870181
SGTC_1009 4106-0057 9.87 µM 0.712271215663618 0.252936006022038 no 900 0.238148422408617 1196 2928005
SGTC_813 k007-0158 173 µM 0.712219590403 0.252951408057189 no 901 0.238164403812823 1191 6523916
SGTC_789 1309-1135 70.6 µM 0.711155900880527 0.253268862198031 no 902 0.238493816240421 1183 3092424
SGTC_1990 st072050 59.8 µM 0.71023127699574 0.253544982810947 no 903 0.238780364166744 1198 17233948
SGTC_2274 7947094 46.08 µM 0.709218411948524 0.253847636315622 no 904 0.23909447473201 1195 2971028
SGTC_308 4092-1169 104 µM 0.707728610690192 0.254293147169233 no 905 0.239556903286845 1163 2268590 YDL196W YDL196W
SGTC_2151 5563267 85.4165 µM 0.707365490556412 0.254401796878258 no 906 0.239669688334745 1171 5310824
SGTC_1950 st077106 7.18 µM 0.706866364548837 0.254551180799685 no 907 0.239824764064733 1129 13831864
SGTC_3307 9126885 69.2785 µM 0.706765736611628 0.25458130340066 no 908 0.239856035245366 1173 24824909
SGTC_971 1315-0384 26.7 µM 0.706492429751724 0.254663126220426 no 909 0.239940979424741 1178 6769120
SGTC_552 k242-0005 476 µM 0.706406508370907 0.2546888522752 no 910 0.239967687307122 1186 4088318
SGTC_2933 9026794 32.47 µM 0.706343239170136 0.254707796822643 no 911 0.239987355001032 1165 17586027
SGTC_2136 5328288 199.296 µM 0.704661085305522 0.255211750663438 no 912 0.24051058705874 1140 262395
SGTC_924 2046-0044 21.3 µM 0.704307347177081 0.255317792822436 no 913 0.240620695900587 1206 3623589
SGTC_1174 0739-0097 51.1 µM 0.703833327372196 0.255459928629056 no 914 0.240768288097664 1184 728447
SGTC_1350 1495-0454 146 µM 0.703797845386066 0.255470569638041 no 915 0.240779337854387 1201 1069057
SGTC_1288 0973-0013 65.5 µM 0.702418547132755 0.255884399096653 no 916 0.24120909101364 1204 4315430
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.701909772127012 0.256037134620279 no 917 0.241367717150771 1164 15053
SGTC_2214 7179297 48.276 µM 0.701168305987645 0.256259809727879 no 918 0.241598993297974 1186 769744
SGTC_3159 9100096 49.47 µM 0.700861984071358 0.256351832959076 no 919 0.241694575526721 1167 25236875
SGTC_311 1315-0136 58 µM 0.700758428888311 0.25638294622622 no 920 0.241726892695624 1200 6759207
SGTC_810 3825-7150 143 µM 0.700405112585213 0.256489115302029 no 921 0.241837172162724 1233 22330411 YGL099W LSG1
SGTC_614 0462-0418 107 µM 0.699365315682288 0.256801699832275 no 922 0.242161878915138 1089 5188303
SGTC_2024 5144227 134 µM 0.699349375990845 0.256806493176985 no 923 0.24216685838501 1191 3475211
SGTC_3229 9132204 49.47 µM 0.698403157679486 0.257091121026185 no 924 0.242462551086696 1196 17682924
SGTC_2393 9031399 185.94 µM 0.696579033249359 0.257640290671017 no 925 0.243033140490338 1220 1526623 YDL150W RPC53
SGTC_1113 artemisinin 1.17947 µM 0.695773498410668 0.257882998172789 no 926 0.243285344219262 1204 2240 An anti-malaria and mitochondrial poison.
SGTC_2331 7980721 200 µM 0.6924905045289 0.258873389264772 no 927 0.244314673484441 1183 2981221
SGTC_2998 9066762 71.4286 µM 0.689450330138057 0.259792280067122 no 928 0.245269960050748 1249 4945196
SGTC_2790 5423970 71.43 µM 0.688689222682638 0.26002258744872 no 929 0.245509429877971 1219 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1976 st070609 63.5 µM 0.688304441120424 0.26013906051484 no 930 0.245630542796593 1164 682556
SGTC_2756 carbadox 75.1 µM 0.683934546644 0.261463708505081 no 931 0.24700824897591 1215 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_476 mead acid 10 µM 0.683705635207762 0.261533193871312 no 932 0.24708053217285 1230 5312531 An omega 9 fatty acid.
SGTC_2749 bexarotene 57.39 µM 0.683487172691917 0.261599516339233 no 933 0.247149526472789 1206 82146 An retinoic acid receptor inhibitor.
SGTC_2469 5655019 90.81 µM 0.682376762524362 0.261936756277548 no 934 0.247500372742524 1250 2788239
SGTC_207 4185-0010 4.486 µM 0.680870113782067 0.26239469302549 no 935 0.247976840115171 1268 3761753
SGTC_229 benomyl 22.8748 µM 0.680226176405823 0.262590538859303 no 936 0.248180630114412 1222 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2777 climbazole 1.536 µM 0.679949382970284 0.262674745247266 no 937 0.248268255721971 1196 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2265 7929201 200 µM 0.679911649349978 0.262686225678614 no 938 0.248280202482972 1226 1265108
SGTC_1184 1269-1718 139 µM 0.678495370715177 0.263117313164547 no 939 0.248728829007928 1232 5403821
SGTC_1783 st039459 87.517 µM 0.67695839633749 0.263585546725254 no 940 0.249216175631348 1272 729761
SGTC_3094 9117742 49.47 µM 0.676085324718402 0.263851713988786 no 941 0.249493236749794 1197 17149698
SGTC_1358 1509-0022 2.48 µM 0.676036268523701 0.263866673474264 no 942 0.249508809129884 1244 3258434
SGTC_2102 5377816 72.7585 µM 0.675005822991701 0.264181003518749 no 943 0.249836032702032 1249 1379702
SGTC_2211 7117706 200 µM 0.674822284901052 0.264237010505115 no 944 0.24989434011284 1180 822771
SGTC_2219 9098279 200 µM 0.674569236760183 0.26431423852543 no 945 0.249974741709203 1228 902349
SGTC_994 3910-0338 138 µM 0.673757537388089 0.264562039413509 no 946 0.250232737522119 1292 3479481
SGTC_2595 hexamethylquercetagetin 100 µM 0.672880857137517 0.264829810791323 no 947 0.250511545811255 1168 386331
SGTC_2396 5342950 42.78 µM 0.671344057022756 0.26529954000464 no 948 0.251000687168338 1237 1886677
SGTC_2418 pentamidine 31.67 µM 0.670608081708761 0.265524643534571 no 949 0.251235116360281 1219 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2194 5927483 104.545 µM 0.670569895895923 0.265536325593206 no 950 0.251247282792788 1254 760979
SGTC_620 0109-0052 432 µM 0.670427993484181 0.265579739610264 no 951 0.251292497238402 1241 493037
SGTC_1253 0550-0034 176 µM 0.670168135870804 0.26565925050027 no 952 0.251375306967663 1209 5969915
SGTC_60 0986-0278 202 µM 0.668012622745664 0.266319256569739 no 953 0.252062767537779 1075 3110598
SGTC_1568 digitonin 820 nM 0.666950235729889 0.266644858549272 no 954 0.252401960538345 1256 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2892 9047358 58.44 µM 0.665603485929085 0.267057901539194 no 955 0.252832288840511 1221 6466771
SGTC_100 0086-0128 49.5915 µM 0.66505973850247 0.267224758290208 no 956 0.253006142382585 1209 93297
SGTC_2826 7992541 19.48 µM 0.664652508587006 0.267349757119851 no 957 0.253136388068594 1305 2985066
SGTC_3267 9137951 49.47 µM 0.664559797151408 0.267378218927241 no 958 0.253166045200225 1234 16643986
SGTC_1169 aniline yellow 25.8 µM 0.664490151645823 0.267399600649556 no 959 0.253188325055414 1219 6051 A DNA damaging agent.
SGTC_2726 cimetidine 79.27 µM 0.663622862915413 0.267665937388999 no 960 0.253465860282774 1232 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1395 3486-0190 4.35 µM 0.662393089024134 0.268043819195288 no 961 0.253859665827681 1288 6748079
SGTC_2841 9004761 38.96 µM 0.661772196322551 0.268234707507734 no 962 0.254058613737078 1161 2991039
SGTC_357 1325-0123 420 µM 0.661751333099689 0.268241122920147 no 963 0.25406530020043 1237 1098503
SGTC_2905 7799065 20.05 µM 0.65929117985336 0.268998157513816 no 964 0.254854402588427 1203 1296806
SGTC_931 2812-0076 566 µM 0.658273697903299 0.269311568699589 no 965 0.255181137923121 1279 3450959
SGTC_3273 9137859 49.47 µM 0.655659459397348 0.270117661627113 no 966 0.25602162946869 1321 2377234
SGTC_1071 trifluoperazine 6.31 µM 0.654587381415808 0.270448582407798 no 967 0.256366725308303 1305 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_756 0508-1999 28.3 µM 0.653334674959746 0.270835514691932 no 968 0.256770271343429 1225 6753853
SGTC_1273 0849-0096 14.1 µM 0.652936912968476 0.270958432015357 no 969 0.256898475260046 1257 5286025
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.650673466152721 0.271658416935834 no 970 0.257628647470891 1357 6728940
SGTC_588 3970-1144 52.9 µM 0.649644271495342 0.271976999223304 no 971 0.257961014561706 1202 1888707
SGTC_1807 st050092 58.9 µM 0.649221239928339 0.272108000487027 no 972 0.258097692427586 1237 5008496
SGTC_590 k048-0076 22.4 µM 0.649060184123153 0.272157883292396 no 973 0.258149738043083 1291 6832814
SGTC_2822 7994718 71.43 µM 0.647927342936924 0.272508879472691 no 974 0.258515972395382 1254 1018011
SGTC_1369 1866-0067 208 µM 0.647204226634895 0.272733045166594 no 975 0.258749888096987 1299 3531355
SGTC_3316 9136639 10.545 µM 0.644056632363738 0.273709862450823 no 976 0.259769355500925 1320 4903665
SGTC_1166 k206-0078 225 µM 0.640998634228392 0.274660529143373 no 977 0.260761785157405 1285 5404595
SGTC_233 rapamycin 362 pM 0.640955933509685 0.27467381540975 no 978 0.260775656864142 1295 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1326 1431-2094 10.8 µM 0.640214352660904 0.274904607747598 no 979 0.261016626511321 1254 616278
SGTC_2954 9074818 52.69 µM 0.639782509008048 0.275039048714311 no 980 0.261157002727179 1296 16648742
SGTC_2327 6189656 200 µM 0.639525913890801 0.275118946886254 no 981 0.261240430572752 1328 5349088
SGTC_322 k048-0136 19.3 µM 0.638340188171022 0.275488304620199 no 982 0.261626128309832 1281 6823282
SGTC_2060 5238662 140 µM 0.636451111761223 0.276077261965644 no 983 0.262241217995645 1260 790130
SGTC_2759 disulfiram 3.38 µM 0.633926510551038 0.276865320740992 no 984 0.263064391738966 1251 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2349 9023730 187.07 µM 0.632236870810883 0.277393359464574 no 985 0.263616053880067 1325 4126287
SGTC_535 2293-4129 48.2 µM 0.631918927248658 0.277492776791752 no 986 0.263719927411868 1305 396118 YIL048W NEO1
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.628290395508519 0.278628609127709 no 987 0.264906861138037 1335 65057 A dermal irritant. YDR527W RBA50
SGTC_1940 st075990 51.1 µM 0.628251648526307 0.278640750227867 no 988 0.264919550349007 1387 1084979
SGTC_542 3381-0244 89.3 µM 0.625452483136202 0.279518530305408 no 989 0.265837062743809 1325 1112843
SGTC_288 1315-0019 35.1 µM 0.625431207091405 0.279525207320998 no 990 0.265844042782768 1332 6811474
SGTC_2275 7947463 200 µM 0.624647744193865 0.279771133722336 no 991 0.266101138378629 1262 1225414
SGTC_549 1661-1316 519 µM 0.621904794646061 0.280632962636214 no 992 0.267002236107439 1334 2857282
SGTC_1235 benzylparaben 21.5 µM 0.62012111731174 0.28119407858037 no 993 0.267589025089616 1300 7180
SGTC_3096 9117468 49.47 µM 0.618507538597985 0.281702150563499 no 994 0.268120415015945 1225 41316311
SGTC_679 0422-0091 41.4 µM 0.61818707272828 0.281803109189343 no 995 0.268226015245897 1304 627384 YHR062C RPP1
SGTC_1232 0279-0259 161 µM 0.617724979550103 0.281948716359871 no 996 0.268378321479875 1329 1560000
SGTC_2164 5685496 200 µM 0.616618422634384 0.282297543533041 no 997 0.268743220105385 1303 759046
SGTC_400 oxethazaine 37.5 µM 0.616540899240262 0.282321989521051 no 998 0.268768793587965 1303 4621 A local anesthetic.
SGTC_88 0180-0332 8.668 µM 0.616375177090565 0.282374251248199 no 999 0.268823466249681 1349 3101745
SGTC_2066 5222451 176 µM 0.615975302469398 0.282500373878251 no 1000 0.268955410112505 1299 2281147
SGTC_2919 7978188 46.38 µM 0.615960187818746 0.282505141652488 no 1001 0.268960398026825 1301 2980291
SGTC_2481 5478948 45.16 µM 0.615541078527331 0.282637361140724 no 1002 0.269098724794208 1329 77792
SGTC_526 4469-0568 170 µM 0.613281102785781 0.283350844427767 no 1003 0.269845243144569 1308 2901964
SGTC_1932 st074806 40.9 µM 0.611864408780566 0.283798540253828 no 1004 0.27031373559858 1411 17251235
SGTC_2679 rapamycin 1 nM 0.611201940909408 0.28400800584409 no 1005 0.270532949309668 1305 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1411 3909-8223 150 µM 0.608829758435657 0.284758671812444 no 1006 0.271318643256936 1328 X1411
SGTC_592 k241-0073 46.5 µM 0.608525330585044 0.284855075085993 no 1007 0.271419555514577 1355 4230158
SGTC_2110 5483698 200 µM 0.606807793239226 0.285399259767835 no 1008 0.271989237811823 1334 2848765 YHR062C RPP1
SGTC_1007 4101-0031 70 µM 0.604098876204284 0.286258558109284 no 1009 0.272888953326685 1323 1146276
SGTC_3138 9097216 49.47 µM 0.603876344077559 0.286329202323783 no 1010 0.272962928713691 1325 25237486
SGTC_1187 1391-0724 117 µM 0.603227917993076 0.286535096417573 no 1011 0.273178538857314 1348 6997986
SGTC_1383 3049-0032 20.7 µM 0.603225982826244 0.286535710994293 no 1012 0.27317918245184 1372 712864
SGTC_307 1501-1223 22.3 µM 0.60292954214995 0.28662986299462 no 1013 0.273277781064303 1309 2830329
SGTC_2727 riluzole 51.77 µM 0.602175977813469 0.286869267265175 no 1014 0.273528502106492 1342 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1149 3909-7961 23.3 µM 0.60176770493196 0.286999013432933 no 1015 0.273664387548355 1303 735261
SGTC_2167 5876490 200 µM 0.601423154486593 0.287108530693463 no 1016 0.273779090234591 1495 686534
SGTC_735 3076-0345 636 µM 0.60063121490774 0.287360328040228 no 1017 0.274042821252268 1403 2888990
SGTC_1218 1348-1416 30.7 µM 0.600139617006831 0.287516684225217 no 1018 0.274206595877167 1332 6787668
SGTC_2540 epiandrosterone 100 µM 0.597724150650374 0.288285524171247 no 1019 0.275012004106347 1400 441302 A steroid.
SGTC_1322 1348-1070 12 µM 0.596386677498375 0.288711656863112 no 1020 0.275458469209304 1321 6758089
SGTC_2913 7966556 36.57 µM 0.596119481827583 0.288796823684843 no 1021 0.275547705146051 1342 2976516
SGTC_2864 9034755 47.6 µM 0.595520625352381 0.288987748103424 no 1022 0.275747758209997 1338 4930451
SGTC_568 1193-0097 7.48 µM 0.592894097850844 0.289825824999025 no 1023 0.276626014100034 1276 3646150
SGTC_2255 7941087 197.44 µM 0.592893917444095 0.289825882602658 no 1024 0.276626074471334 1402 935561
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.591792469122315 0.290177673649803 no 1025 0.276994783374937 1367 5379071
SGTC_1986 st071812 45 µM 0.591700854681033 0.290206943352233 no 1026 0.277025462066442 1355 11838594
SGTC_2910 7948405 25.97 µM 0.590321704224136 0.290647732233897 no 1027 0.277487495486681 1378 2971328
SGTC_1715 st032160 10.2275 µM 0.587533965947546 0.291539673466781 no 1028 0.278422572740546 1331 5289825
SGTC_215 1287-0124 461.5 µM 0.587504905992896 0.291548977963509 no 1029 0.278432328258028 1409 5560863
SGTC_324 1315-0088 19.6 µM 0.587120935320825 0.291671931756866 no 1030 0.27856124404851 1314 6787421
SGTC_81 0411-0046 9.971 µM 0.586597299731667 0.291839647523566 no 1031 0.278737098320015 1263 12925265
SGTC_2228 7354201 200 µM 0.586276947587652 0.291942275577178 no 1032 0.278844709877634 1383 753451
SGTC_602 3130-1533 38.1 µM 0.582064819841785 0.293293233891713 no 1033 0.280261510280688 1419 720941
SGTC_1437 4092-1038 11.6 µM 0.581316862877345 0.293533429197743 no 1034 0.280513458799461 1346 3977136
SGTC_1837 st055472 66.5 µM 0.580995647982536 0.293636610559449 no 1035 0.280621693337468 1425 676091
SGTC_835 0312-0010 67.2 µM 0.580190744758489 0.29389523708171 no 1036 0.280892997149536 1341 1626196
SGTC_3003 9075612 71.4286 µM 0.57922428541705 0.29420591293574 no 1037 0.281218923119429 1371 6501993
SGTC_1382 3002-2117 298 µM 0.578726102474928 0.294366116948423 no 1038 0.281387000199738 1434 1497314
SGTC_3147 9097027 49.47 µM 0.578722879116228 0.294367153636528 no 1039 0.281388087855104 1453 25236841
SGTC_1250 0485-0349 40.2 µM 0.578014997618985 0.294594861436975 no 1040 0.281626996882599 1371 6842794 YDL195W SEC31
SGTC_2148 5546263 113.568 µM 0.575899915680502 0.295275714157768 no 1041 0.2823414163087 1370 792097
SGTC_1195 1502-0147 41.1 µM 0.572989307072509 0.296213832043716 no 1042 0.283325967020005 1364 817940
SGTC_33 0986-0033 35.816 µM 0.572207081011666 0.296466184117658 no 1043 0.283590845427987 1369 2848082
SGTC_1140 3229-1848 2.98 µM 0.571822519601977 0.296590282667002 no 1044 0.283721109600665 1377 2849525
SGTC_2564 betulinic acid 100 µM 0.570608745488294 0.296982125405253 no 1045 0.284132444475148 1523 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_499 genistein 192 µM 0.570460452618943 0.297030015026716 no 1046 0.284182718863383 1407 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2552 juarezic acid 87.02 µM 0.570379812687548 0.297056058326326 no 1047 0.28421005927417 1404 1549512
SGTC_1758 st042942 75.2445 µM 0.569715700515537 0.297270578273818 no 1048 0.284435269724747 1347 669317
SGTC_89 0302-0250 142.109 µM 0.569564117923308 0.297319552046696 no 1049 0.284486685615983 1422 4203518 YLR208W SEC13
SGTC_993 3909-8757 62.7 µM 0.568907525103757 0.297531728639428 no 1050 0.284709449147845 1387 4288324 YLR208W SEC13
SGTC_3166 9102297 49.47 µM 0.567863304499995 0.29786930864971 no 1051 0.285063895322026 1329 25237072
SGTC_2532 xanthone 78.9 µM 0.56775168414819 0.297905404074604 no 1052 0.285101795741818 1407 7020 An insecticide.
SGTC_2261 9010538 184.68 µM 0.567046191480117 0.29813359011065 no 1053 0.285341399620467 1319 6457250
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.567020485239337 0.298141906094651 no 1054 0.285350131947216 1372 688664
SGTC_2341 7987486 176.74 µM 0.56699531366265 0.298150049216896 no 1055 0.285358682773643 1434 1258686
SGTC_816 0325-0417 81.3 µM 0.565973028024751 0.298480848953576 no 1056 0.285706057986274 1364 68101
SGTC_1664 st014217 9.02 µM 0.564869649465729 0.298838076680105 no 1057 0.286081214367649 1428 3982782
SGTC_1109 tnp00067 928.257 nM 0.563444644213045 0.299299720885218 no 1058 0.286566072115609 1372 676295
SGTC_140 0062-0056 502.533 µM 0.560731053494196 0.300179708108886 no 1059 0.287490447183913 1327 3758964
SGTC_2205 7238770 200 µM 0.559592633195515 0.30054923315286 no 1060 0.287878665426302 1416 279867
SGTC_3026 9090633 49.47 µM 0.559159886857029 0.300689754125033 no 1061 0.288026303273153 1360 25236842
SGTC_1844 rapamycin 4 nM 0.558090227573876 0.301037220015399 no 1062 0.288391386704506 1389 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1485 3909-9022 254 µM 0.557210083063057 0.301323259974096 no 1063 0.28869195070386 1391 714516
SGTC_2051 5263410 176 µM 0.55627785735558 0.301626359291123 no 1064 0.289010460897102 1422 227584
SGTC_348 k064-0012 10.7 µM 0.556084684323197 0.301689183775968 no 1065 0.289076482300991 1350 5066323
SGTC_2895 9054447 58.44 µM 0.555700633226286 0.301814103841732 no 1066 0.2892077618153 1415 2697450
SGTC_1685 st024049 53.0905 µM 0.551829562013507 0.30307454069551 no 1067 0.290532565664473 1386 1941139
SGTC_559 1550-0661 158 µM 0.551767332464242 0.303094822114956 no 1068 0.290553885772346 1472 5830875
SGTC_474 dl-dihydrosphingosine 5 µM 0.551685731233099 0.303121417937444 no 1069 0.290581843810061 1445 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_3350 9150499 3.57 µM 0.548757835061526 0.304076380127602 no 1070 0.29158582506163 1367 4910996 YPR165W RHO1
SGTC_771 0250-0039 27.3 µM 0.548626992122084 0.304119087125634 no 1071 0.291630729087433 1424 3005115
SGTC_2004 4023728 41.89 µM 0.547297676606882 0.304553125741375 no 1072 0.292087119902868 1421 360084 YDR527W RBA50
SGTC_1857 st056007 79.3 µM 0.546608916860974 0.304778122992129 no 1073 0.292323720862874 1411 619834
SGTC_3082 9117008 49.47 µM 0.545714685611289 0.305070351834077 no 1074 0.292631037773441 1417 41448529
SGTC_1158 4092-0494 91.8 µM 0.544521554692637 0.305460452717428 no 1075 0.293041309914318 1507 1148199
SGTC_1683 st010134 710 nM 0.541270525421493 0.306524515560146 no 1076 0.294160566549176 1399 3818134
SGTC_1911 st060208 74.3 µM 0.539954314057126 0.306955776911194 no 1077 0.29461426974553 1499 688783
SGTC_1415 3966-0071 78.1 µM 0.539581613003583 0.30707794231983 no 1078 0.294742799877738 1415 2893185
SGTC_1908 st060353 56.5 µM 0.539142700941821 0.307221838096424 no 1079 0.294894196763477 1555 4227716
SGTC_1190 1486-1332 13 µM 0.536849592096471 0.307974108092383 no 1080 0.295685756330227 1392 4150046
SGTC_1968 st069590 43.6 µM 0.534054718646718 0.308892077392927 no 1081 0.296651838445915 1443 6384066
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.532198176467976 0.309502515098353 no 1082 0.297294372907675 1493 688798
SGTC_2431 5490079 200 µM 0.529372651587589 0.310432566855506 no 1083 0.298273482984938 1429 5722345
SGTC_1905 st060207 84.5 µM 0.528248100070404 0.310803062917375 no 1084 0.29866357428163 1443 1948547
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.527738378626812 0.31097105957337 no 1085 0.298840465934782 1443 6708784 An antioxidant flavonoid
SGTC_2152 5568786 200 µM 0.527049298996368 0.311198232671495 no 1086 0.29907967697127 1422 5399883
SGTC_2966 9084041 48.03 µM 0.526629335396113 0.311336719928522 no 1087 0.299225508153979 1320 17741380
SGTC_654 1124-0271 80.9 µM 0.526309620714494 0.311442166992431 no 1088 0.299336549807312 1409 5403748
SGTC_1276 0871-0068 94.2 µM 0.525137277861911 0.311828956906181 no 1089 0.299743881700895 1489 3414906
SGTC_1469 k284-2957 126 µM 0.523782534871333 0.312276184526299 no 1090 0.300214901135284 1486 23884841
SGTC_169 k015-0017 16.025 µM 0.523437320902813 0.312390190795288 no 1091 0.300334979216538 1526 1840002
SGTC_689 0833-0039 98 µM 0.521993312465436 0.312867266486492 no 1092 0.300837493424959 1481 5374726
SGTC_2682 pyrogallin 40.03 µM 0.52197369691468 0.31287374928949 no 1093 0.30084432223706 1470 822798 An ATP competetive kinase inhibitor.
SGTC_3222 9128301 49.47 µM 0.521482571110873 0.313036081807853 no 1094 0.301015321911239 1440 4911358
SGTC_1782 st039423 80.636 µM 0.520960563846243 0.313208661360839 no 1095 0.301197121878566 1407 2068169
SGTC_1470 k295-0292 231 µM 0.520869634998073 0.313238727312126 no 1096 0.301228794812865 1503 5045612
SGTC_3245 9134821 49.47 µM 0.51716156769909 0.314465868876106 no 1097 0.302521688983098 1390 17014901
SGTC_131 0141-0277 33.849 µM 0.516502447077336 0.314684212406764 no 1098 0.30275176513444 1518 1547771
SGTC_2661 dactinomycin 12.96 µM 0.513910758431464 0.315543375783406 no 1099 0.303657192689366 1457 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2795 7780010 54.55 µM 0.513179733101453 0.315785896587565 no 1100 0.303912800735397 1460 953673
SGTC_2089 5281248 129.67 µM 0.512031969356711 0.316166832189463 no 1101 0.304314317707973 1449 2737878
SGTC_2911 7942208 15.64 µM 0.511767628065768 0.316254593081362 no 1102 0.30440682447507 1424 1243384
SGTC_2067 5224629 34.075 µM 0.504961208840711 0.318517866575235 no 1103 0.306793040874259 1443 2835000
SGTC_2728 chlorpromazine 9.18 µM 0.503027393526566 0.319162141822474 no 1104 0.307472506333684 1500 2726 A thorazine and dopamine antagonist.
SGTC_1212 0520-0165 585 µM 0.502709959146713 0.319267951411663 no 1105 0.307584103329479 1682 5403258
SGTC_2246 7293507 91.5585 µM 0.502546705639896 0.319322374018428 no 1106 0.307641503547116 1606 887656
SGTC_1418 3966-3099 2.4 µM 0.498719819459473 0.320599227710284 no 1107 0.30898839006056 1543 740335
SGTC_1761 st044296 37 µM 0.498461045572234 0.320685645406071 no 1108 0.309079559515142 1458 1826700
SGTC_814 3342-0569 96 µM 0.498460401339034 0.320685860560267 no 1109 0.309079786501676 1506 4346283
SGTC_1767 st044992 70.3 µM 0.497521702116704 0.320999421366089 no 1110 0.309410601402277 1421 9600693
SGTC_2513 baicalein 25.65 µM 0.496752890429275 0.321256328489578 no 1111 0.309681659928719 1412 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_114 0364-0001 490.298 µM 0.496650979217133 0.321290389698836 no 1112 0.309717598352572 1419 4003655
SGTC_629 3448-6466 76.7 µM 0.496620876133112 0.321300451170302 no 1113 0.309728214386258 1483 573744
SGTC_3115 9123671 49.47 µM 0.495075107951693 0.321817275441138 no 1114 0.310273551983123 1561 3286988
SGTC_398 bronopol 33.3 µM 0.493501330172966 0.322343819046553 no 1115 0.310829200096098 1514 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1148 3909-7663 27.7 µM 0.493231595421845 0.322434100850361 no 1116 0.310924477750239 1555 4084526
SGTC_1836 st055642 81 µM 0.492275664817967 0.322754140729794 no 1117 0.311262240487524 1401 8571
SGTC_1247 0448-0043 5.84 µM 0.489914540776385 0.323545193429468 no 1118 0.312097186580928 1506 3089013 YGL099W LSG1
SGTC_389 tpck 16.7 µM 0.487631640432734 0.32431079770986 no 1119 0.31290538995591 1493 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.487187604773142 0.324459798067998 no 1120 0.313062694274479 1526 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3338 9144300 39.5675 µM 0.486888353373173 0.324560230556188 no 1121 0.313168726439333 1537 4901274
SGTC_2413 inermin 26.06 µM 0.485211713811645 0.325123167466262 no 1122 0.313763086838493 1634 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2390 9097792 176.6 µM 0.484864083645675 0.325239935400444 no 1123 0.313886380592812 1444 4497149
SGTC_2893 9048488 25.97 µM 0.483552827180405 0.325680536906175 no 1124 0.314351629984543 1431 6467338
SGTC_1033 k072-0102 21.3 µM 0.483226361537579 0.325790272079476 no 1125 0.314467509782332 1621 5965931
SGTC_834 0312-0008 75.7 µM 0.482455878394546 0.326049315070249 no 1126 0.314741067176574 1522 6385573 YIL048W NEO1
SGTC_784 4579-0127 173 µM 0.477493758120053 0.327719629398933 no 1127 0.316505282275321 1644 1948547
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.477157619913248 0.32783290314768 no 1128 0.316624943420912 1507 4620898
SGTC_3171 9103192 49.47 µM 0.477016880556763 0.327880334995575 no 1129 0.316675050634832 1555 13018434
SGTC_2320 7373003 200 µM 0.473855285839605 0.328946583278613 no 1130 0.317801553435977 1442 5415828
SGTC_3074 9116018 49.47 µM 0.472999412322711 0.329235466781078 no 1131 0.318106799225779 1560 17027303
SGTC_1581 himbacine 57.9 µM 0.472429667574811 0.329427829622839 no 1132 0.318310066226229 1499 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2773 thioridazine 9.09 µM 0.472408897058203 0.329434843222847 no 1133 0.318317477527159 1531 5452 An antipsychotic.
SGTC_2607 solasodine 47.35 µM 0.472375886051667 0.329445990204151 no 1134 0.318329256608826 1514 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_69 0096-0274 206.684 µM 0.472329905295702 0.329461516994122 no 1135 0.318345663899643 1601 6741392
SGTC_2878 9043973 25.97 µM 0.47174127510431 0.329660311711222 no 1136 0.318555735995293 1598 6465167
SGTC_1349 flufenamic acid 69 µM 0.470186228499687 0.330185720176612 no 1137 0.319110986157892 1496 3371 A non-steroidal anti-inflammatory.
SGTC_2584 androsterone 48.74 µM 0.469110372957472 0.330549419015953 no 1138 0.319495372498935 1542 2754130 A steroid.
SGTC_537 1334-0398 209 µM 0.468893229016347 0.330622845136875 no 1139 0.319572978175598 1623 5846986
SGTC_1275 0867-0008 21.1 µM 0.468025360391102 0.330916375576772 no 1140 0.31988322703159 1548 3422836
SGTC_2325 6158266 200 µM 0.465650261754755 0.331720212407782 no 1141 0.320732929931402 1519 3623240
SGTC_1204 4049-0315 18.3 µM 0.464957055700247 0.331954969887807 no 1142 0.320981105143136 1647 588402
SGTC_2687 chenodiol 100 µM 0.464404822032968 0.332142033634746 no 1143 0.321178867983403 1569 5702181 A cholesterol synthesis inhibitor.
SGTC_1410 3909-8106 77.9 µM 0.463028306088064 0.332608496958865 no 1144 0.32167203889326 1592 1039210
SGTC_1792 st045773 43.6 µM 0.460716083023125 0.333392628970877 no 1145 0.32250115734997 1528 2919270
SGTC_2100 5377183 190 µM 0.460666298207338 0.333409520257627 no 1146 0.322519018952769 1641 2844202
SGTC_2412 st077135 33.4 µM 0.46027610159892 0.333541920167595 no 1147 0.322659026360709 1623 13258915
SGTC_2352 9027995 87.8 µM 0.459981724269603 0.333641820797717 no 1148 0.322764669260119 1572 2997347
SGTC_2942 9052777 62.25 µM 0.459625449734443 0.333762742796366 no 1149 0.322892544281714 1597 6469503
SGTC_1886 st057356 49.9 µM 0.45848549323456 0.334149767744626 no 1150 0.323301841195716 1473 24207747
SGTC_919 tnp00227 403.569 nM 0.456866128849862 0.334699858994248 no 1151 0.323883635410594 1567 1269246 A methoxyflavone. YNL221C POP1
SGTC_959 1222-0044 107 µM 0.455386087294925 0.335202933390534 no 1152 0.324415751311949 1621 6083612
SGTC_1130 3454-2858 15.9 µM 0.454899395078346 0.335368427451755 no 1153 0.324590809063093 1504 715628 YIL048W NEO1
SGTC_1355 1499-0035 1.68 µM 0.45240038372631 0.336218690019959 no 1154 0.325490285288834 1518 1548538
SGTC_138 0850-0259 40.9225 µM 0.450862278401993 0.336742431509066 no 1155 0.32604440601917 1535 6813004
SGTC_1966 st070145 16.1 µM 0.449130234260933 0.337332590470652 no 1156 0.326668855621921 1509 3748532
SGTC_2467 5474540 200 µM 0.448150151198817 0.337666711425626 no 1157 0.32702241793658 1505 5413519
SGTC_632 0781-2353 4.65 µM 0.446253604748796 0.338313627987232 no 1158 0.327707032802349 1589 6811515 YHR007C ERG11
SGTC_663 1486-0733 13.9 µM 0.445484095416751 0.33857624577989 no 1159 0.327984975511958 1561 722445 YPR165W RHO1
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.44068091598394 0.340217242856621 no 1160 0.32972200718475 1577 1241132 A phosphatase inhibitor.
SGTC_1569 carminic acid 40.6 µM 0.439833528773465 0.340507066482097 no 1161 0.330028840906275 1630 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_208 k072-0098 12.366 µM 0.439335883089327 0.340677315328057 no 1162 0.3302090886841 1572 5948901
SGTC_2294 7971431 200 µM 0.438893599985753 0.340828651409175 no 1163 0.330369317159029 1567 5741572
SGTC_1810 st050138 53 µM 0.438807731027002 0.340858036175309 no 1164 0.330400429013274 1634 3444541
SGTC_1805 st050013 60.3 µM 0.434955020970141 0.342177443069816 no 1165 0.331797538024442 1609 4037144
SGTC_1895 st058434 18.3 µM 0.434392604634352 0.34237021104517 no 1166 0.332001683566511 1684 5393175
SGTC_3282 9108498 15.4605 µM 0.434104399453567 0.342469009176272 no 1167 0.332106315442082 1551 16459645
SGTC_3010 9080089 71.4286 µM 0.433551124136401 0.34265870483981 no 1168 0.332307216780052 1661 17027233
SGTC_1225 1216-0074 20.6 µM 0.433425124859253 0.342701910430565 no 1169 0.332352975467315 1550 4241466
SGTC_1669 st015249 58.4 µM 0.432491136559835 0.343022242396494 no 1170 0.332692246392166 1642 722793
SGTC_659 k018-0002 107 µM 0.432029973070221 0.343180450259521 no 1171 0.332859814433774 1682 6797879 YHR007C ERG11
SGTC_572 0960-0087 17.7 µM 0.430975154860783 0.343542422061495 no 1172 0.333243217916915 1505 6796365
SGTC_2797 7859098 81.82 µM 0.430713219418107 0.343632330181704 no 1173 0.333338452789089 1564 972681
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.430415467153956 0.34373454300224 no 1174 0.333446723042659 1617 2724278 An inhibitor of dopamine biosynthesis.
SGTC_534 k292-0788 63.4 µM 0.429170258471806 0.344162123724273 no 1175 0.33389966268317 1722 4146317
SGTC_95 0471-0001 561.058 µM 0.426854537918027 0.344957827289296 no 1176 0.334742640084501 1503 4015405
SGTC_110 0850-0284 111.64 µM 0.424976380309615 0.345603684201679 no 1177 0.335426946598489 1511 3906265
SGTC_2710 st078562 53.7235 µM 0.423635025577336 0.346065221853127 no 1178 0.335916003632686 1529 17250908
SGTC_3331 9141060 1.957 µM 0.420546446802229 0.347128818851249 no 1179 0.337043153141477 1549 4906567 YPR165W RHO1
SGTC_2283 7944793 200 µM 0.420169613686009 0.347258669476879 no 1180 0.337180775506945 1522 2970533
SGTC_938 3126-1755 342 µM 0.419044437443628 0.347646493750301 no 1181 0.337591828177153 1636 1777771
SGTC_249 wiskostatin 11.211 µM 0.415935797464465 0.348718803719995 no 1182 0.338728491953759 1675 2775510 A n-wasp and actin depolymerizer.
SGTC_337 1315-0038 354 µM 0.415844962122593 0.348750155152021 no 1183 0.338761727750164 1593 1626437
SGTC_2403 6032726 181.2 µM 0.415658261346796 0.348814597373873 no 1184 0.338830043748139 1583 2881040
SGTC_1531 st059297 52.4 µM 0.415268030121906 0.348949304883869 no 1185 0.338972851037791 1625 7566702
SGTC_1396 3511-0007 98.6 µM 0.414693438933919 0.349147687960076 no 1186 0.339183168005102 1592 X1396
SGTC_2018 5133068 143 µM 0.413926556631227 0.349412525602709 no 1187 0.33946394714954 1581 785362
SGTC_2292 7671323 168.05 µM 0.413688132195261 0.349494878825861 no 1188 0.339551259824031 1580 937504
SGTC_1073 triclabendazole 3.09 µM 0.412643381083413 0.349855825586636 no 1189 0.339933956391598 1635 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1929 genistein trimethyl ether 50.5 µM 0.41136600589498 0.350297325092164 no 1190 0.340402088291717 1783 136420
SGTC_372 0155-0182 15.9 µM 0.411356644187662 0.350300561529107 no 1191 0.340405520075147 1684 771486
SGTC_1496 4469-0713 57.4 µM 0.410655627922138 0.350542940812982 no 1192 0.340662533807802 1703 746691
SGTC_2960 9079389 5.97 µM 0.409619125527296 0.350901427316377 no 1193 0.341042682449291 1731 16457355
SGTC_2440 5628896 157.78 µM 0.407904753677294 0.351494654192175 no 1194 0.341671801323123 1633 5522048
SGTC_3153 9100258 49.47 µM 0.406057843331384 0.352134148519383 no 1195 0.342350049930433 1565 25236848
SGTC_2718 lomofungin 53.02 µM 0.405834381241698 0.352211550872091 no 1196 0.342432147393921 1715 5351222 A RNA synthesis inhibitor.
SGTC_289 k017-0060 526 µM 0.405542174235819 0.352312774188739 no 1197 0.342539512201244 1609 5512909
SGTC_2016 5121758 140 µM 0.401375929610039 0.353757136318454 no 1198 0.34407168417388 1580 2795203
SGTC_3305 9127027 53.8275 µM 0.400826706573681 0.35394769975307 no 1199 0.344273857411305 1631 41905295
SGTC_2405 ticlatone 3.52 µM 0.397482127943798 0.355108953619351 no 1200 0.345505981604333 1440 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_645 0845-0943 5.41 µM 0.396277564734267 0.355527514292106 no 1201 0.345950138073392 1628 1885106
SGTC_1812 st052057 4.327 µM 0.395777421404419 0.355701354937894 no 1202 0.346134617378068 1592 3645418
SGTC_2490 carminic acid 95.39 µM 0.39568948852974 0.355731921895442 no 1203 0.346167055447597 1629 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1565 sinapyl alcohol 95.1 µM 0.394752237122577 0.356057783972827 no 1204 0.346512873655983 1563 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1766 st045414 44.774 µM 0.393177960552177 0.356605362530536 no 1205 0.347094023281884 1629 253960
SGTC_1964 st076914 61 µM 0.392863679298798 0.35671471400964 no 1206 0.347210084416782 1628 24208661
SGTC_1479 0549-0158 134 µM 0.392830778258286 0.356726162326942 no 1207 0.347222235292928 1642 5440202
SGTC_3191 9110352 49.47 µM 0.39189224854788 0.357052789471555 no 1208 0.347568915294916 1657 17122424
SGTC_2124 5246320 200 µM 0.386104245829707 0.359069438262755 no 1209 0.349709732745561 1675 579342
SGTC_3271 9137798 49.47 µM 0.385926973360773 0.359131265683179 no 1210 0.349775376690348 1756 6498326
SGTC_55 0767-0285 6.563 µM 0.385820216734943 0.3591685010328 no 1211 0.349814910805329 1761 3116166
SGTC_825 1988-2224 89.6 µM 0.384878498211794 0.359497018357141 no 1212 0.350163718514547 1653 1180859
SGTC_2096 5468907 200 µM 0.383351607915493 0.360029892776618 no 1213 0.350729539448476 1763 759785
SGTC_3170 9103054 49.47 µM 0.382629590356766 0.360281966863817 no 1214 0.350997213497928 1613 16432970
SGTC_43 0570-0105 72.5 µM 0.382430054133318 0.360351640585749 no 1215 0.351071200743702 1673 1114046 YDL195W SEC31
SGTC_3158 9100007 49.47 µM 0.382015847227845 0.360496287458071 no 1216 0.351224805055102 1606 19297233
SGTC_1556 plumbagin 1.48 µM 0.379985499121882 0.361205601995814 no 1217 0.351978089647833 1646 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_750 4073-0104 132 µM 0.379094581682444 0.361517000324636 no 1218 0.35230881486797 1589 22330957
SGTC_1049 3226-0134 66 µM 0.375778180451517 0.362676971973812 no 1219 0.353540905209215 1661 5702385
SGTC_2643 anethole 100 µM 0.375613693374736 0.362734537241368 no 1220 0.353602054591096 1669 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1850 st056238 17 µM 0.375272873602591 0.362853823240674 no 1221 0.353728769080814 1624 5393177
SGTC_1394 3474-0001 65.7 µM 0.373823399398436 0.363361283833195 no 1222 0.354267854691149 1629 5017666 YIL048W NEO1
SGTC_2981 9013952 38.96 µM 0.373556400124557 0.363454786409917 no 1223 0.354367188435192 1553 2996344
SGTC_2373 9071805 200 µM 0.37263132323803 0.363778809255591 no 1224 0.354711428327578 1812 10149009
SGTC_2249 haloperidol 116.36 µM 0.369264029140291 0.364959078758879 no 1225 0.35596546721647 1724 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2854 9024559 71.43 µM 0.36893474346811 0.36507456552644 no 1226 0.356088182875363 1612 3163529
SGTC_766 1391-0721 126 µM 0.368767755656512 0.365133136015749 no 1227 0.356150420310449 1765 1020919 YIL115C NUP159
SGTC_2208 7283366 200 µM 0.368274452636574 0.3653061789872 no 1228 0.356334299908694 1763 898663
SGTC_2061 5245884 80.95 µM 0.367091302057985 0.365721321386246 no 1229 0.356775457520707 1661 573863
SGTC_2698 st077697 67.5 µM 0.3661913188383 0.366037211747083 no 1230 0.357111159778865 1606 3154499
SGTC_175 3793-3120 23.7 µM 0.365989646177465 0.36610801047525 no 1231 0.357186400774468 1665 5322297
SGTC_1795 st049545 62.3 µM 0.3656795407544 0.366216884246498 no 1232 0.35730210721547 1803 5291882
SGTC_1301 naphtanilide LB 4.81 µM 0.365023971320892 0.366447081148058 no 1233 0.357546756262026 1784 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.364552467917262 0.366612674751067 no 1234 0.357722750729009 1736 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_692 k241-0027 77.8 µM 0.364296270785083 0.36670266247147 no 1235 0.357818392159514 1756 3600480
SGTC_982 1491-0518 27.5 µM 0.363428188181768 0.367007625774219 no 1236 0.358142524034251 1692 3091256
SGTC_540 1187-0821 17.3 µM 0.362098280650884 0.367474994053326 no 1237 0.358639294218802 1629 847520
SGTC_2940 9060638 45.86 µM 0.360362451592683 0.368085310333672 no 1238 0.359288051131945 1703 4027022
SGTC_1408 3909-7976 48.8 µM 0.360237455366326 0.368129271794531 no 1239 0.359334783497897 1716 24152374
SGTC_3055 9094636 49.47 µM 0.36020766434543 0.368139749620093 no 1240 0.359345921783826 1746 25236176
SGTC_1377 2944-0135 198 µM 0.358190043919455 0.368849596539121 no 1241 0.36010054871763 1723 1894137
SGTC_342 k048-0088 23.3 µM 0.357888643971523 0.368955674706587 no 1242 0.360213324710926 1635 6820570
SGTC_2397 5161689 200 µM 0.355937832031521 0.369642507001628 no 1243 0.36094356142182 1753 2259942
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.355307047826674 0.369864679549279 no 1244 0.361179788043901 1647 6708760
SGTC_2006 4011487 200 µM 0.354592103818122 0.370116547083051 no 1245 0.361447596250529 1797 45595294
SGTC_2779 methotrexate 400 µM 0.35450735689301 0.370146406261748 no 1246 0.361479345788547 1716 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_898 1000-0849 28.3 µM 0.354051704934062 0.370306961112094 no 1247 0.361650067316299 1758 6751807
SGTC_2112 5488546 200 µM 0.353169851397123 0.370617757758523 no 1248 0.36198055425264 1675 600757
SGTC_1156 4092-0367 4.88 µM 0.353053351421185 0.370658822825997 no 1249 0.362024221949708 1715 1357585
SGTC_1052 3253-3998 198 µM 0.35226534142012 0.370936627081446 no 1250 0.362319638949941 1667 5450317
SGTC_576 1073-0113 22.7 µM 0.350843931512094 0.371437899560813 no 1251 0.362852718473406 1772 5439563
SGTC_3318 9139014 38.6185 µM 0.350800101587432 0.37145336003321 no 1252 0.36286916049284 1702 16643984
SGTC_92 0063-0024 660.874 µM 0.350775952413575 0.371461878448942 no 1253 0.362878219735432 1743 3594437
SGTC_729 4092-0585 94.1 µM 0.350434464662733 0.371582342086761 no 1254 0.363006332553398 1655 2169061
SGTC_1871 st057448 67.3 µM 0.349710706185569 0.37183769757857 no 1255 0.363277909030076 1788 691747
SGTC_728 3030-5151 22.5 µM 0.349370723869713 0.371957669155221 no 1256 0.363405504607537 1728 3125388
SGTC_506 n9-isopropylolomoucine 153 µM 0.347553692986671 0.372599066147089 no 1257 0.364087694091893 1874 6610355
SGTC_305 1682-2595 20.8 µM 0.345976131439506 0.373156219161446 no 1258 0.364680326328756 1745 226033
SGTC_1495 4469-0029 237 µM 0.344943288219533 0.373521135882052 no 1259 0.365068503129606 1675 793680
SGTC_3127 9126946 49.47 µM 0.344481419231176 0.373684356829964 no 1260 0.365242133621515 1640 27243249
SGTC_1478 0453-0656 35.7 µM 0.344365953476482 0.37372516508099 no 1261 0.365285545001497 1717 5258496
SGTC_460 trequinsin 123 µM 0.343042934506748 0.374192851325358 no 1262 0.365783080313263 1725 5537 A vasodilator.
SGTC_1249 0481-0015 10.2 µM 0.341479270134656 0.37474584432325 no 1263 0.366371404037602 1674 4227577
SGTC_259 usnic acid 108.925 µM 0.340980234794572 0.374922383450594 no 1264 0.366559230694685 1777 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1720 st037298 9.481 µM 0.339054070095748 0.37560403048668 no 1265 0.367284498954686 1691 597396
SGTC_561 1550-0330 72.9 µM 0.337503624824375 0.376152997159156 no 1266 0.367868640034857 1691 6812934
SGTC_1296 1068-0102 11.9 µM 0.334758118748962 0.377125713769084 no 1267 0.368903777906661 1794 767053
SGTC_2168 5727979 200 µM 0.333937003720215 0.377416781833615 no 1268 0.369213548035866 1690 695210
SGTC_263 alizarin 107.927 µM 0.332916575303365 0.377778599353596 no 1269 0.369598628592675 1755 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_297 0986-0032 24 µM 0.332891185724414 0.377787603210365 no 1270 0.369608211564759 1719 2847425
SGTC_980 1473-0395 201 µM 0.331745342330879 0.378194020462571 no 1271 0.370040779736688 1696 768876
SGTC_581 0958-0271 211 µM 0.331265466039983 0.378364267049958 no 1272 0.370221987073902 1683 4591145
SGTC_1802 st050112 57.9 µM 0.330703224943747 0.378563764390761 no 1273 0.370434333046635 1752 4662563
SGTC_3216 9129716 49.47 µM 0.33006325221749 0.378790882264388 no 1274 0.370676084578202 1662 8056934
SGTC_1238 0333-0287 48.8 µM 0.32991375244968 0.378843943793464 no 1275 0.370732565905874 1715 7226
SGTC_2649 anisomycin 9.56 µM 0.329514124525629 0.378985793808686 no 1276 0.370883559852069 1744 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3174 9107204 49.47 µM 0.329446340597024 0.379009855684854 no 1277 0.370909173055574 1794 3938802
SGTC_1108 betulinic acid 729.144 nM 0.328462280532849 0.379359229181339 no 1278 0.371281079711408 1719 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2733 amorolfine 100 µM 0.328438723951896 0.379367593746593 no 1279 0.371289983944821 1838 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_621 3584-0052 32.1 µM 0.324126285268042 0.380899819421903 no 1280 0.372921213733649 1847 2273927
SGTC_1574 spiramycin 23.7 µM 0.320830603832928 0.382072049217055 no 1281 0.374169382940418 1695 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1045 1348-1485 165 µM 0.320165052069412 0.382308908724208 no 1282 0.374421607156322 1748 6810614
SGTC_801 0866-0028 10.1 µM 0.319980416347628 0.382374625510007 no 1283 0.374491588102 1755 6849771
SGTC_2355 9061122 103.12 µM 0.317696681725232 0.383187747230784 no 1284 0.375357514258748 1865 5302957
SGTC_966 1300-0360 30.2 µM 0.317595199325874 0.383223891925634 no 1285 0.375396008065807 1728 70588
SGTC_680 0417-1641 114 µM 0.317499180398137 0.383258091647445 no 1286 0.37543243063785 1724 2835990
SGTC_328 k915-0120 63.5 µM 0.316887640555265 0.383475929338283 no 1287 0.37566443025743 1865 6624543
SGTC_1640 st009078 66.4 µM 0.316093051971316 0.383759026167866 no 1288 0.375965940156909 1842 690618
SGTC_1132 3456-3614 2.5 µM 0.31523733212779 0.384063972299655 no 1289 0.376290731261172 1935 3125502
SGTC_2791 5663188 71.43 µM 0.314466328518325 0.384338790263077 no 1290 0.376583443106496 1849 54690634
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.313170753850615 0.384800718202782 no 1291 0.37707546833858 1709 688669
SGTC_180 1486-1293 102.781 µM 0.311985717331534 0.385223377808568 no 1292 0.377525688949086 1929 4140536
SGTC_1755 st041960 45.185 µM 0.31021762348285 0.385854246253144 no 1293 0.378197734786143 1782 2257073
SGTC_2492 derrusnin 100 µM 0.310056259391461 0.385911837171522 no 1294 0.378259087061192 1739 1715307 Part of coumarin class of compounds.
SGTC_2814 7977482 42.97 µM 0.309509701822813 0.386106922494549 no 1295 0.378466916627422 1868 6456762
SGTC_2142 5622915 118.518 µM 0.309084358019333 0.386258762358368 no 1296 0.378628678757753 1744 5322196
SGTC_1118 chelidonine 707.474 nM 0.308584665436543 0.386437165613687 no 1297 0.378818743574447 1909 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2512 diallyl trisulfide 49.23 µM 0.308186033458553 0.386579504821032 no 1298 0.378970389646023 1790 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_567 1080-0542 68.4 µM 0.307727838446769 0.386743131005026 no 1299 0.379144717475686 1879 5950415
SGTC_1575 cyproterone acetate 48 µM 0.304218468095694 0.387997029175361 no 1300 0.380480727863842 1705 9880 An androgen receptor antagonist and liver toxin.
SGTC_3303 9125618 40.5795 µM 0.304040985483086 0.388060474874826 no 1301 0.380548333183101 1852 22695467
SGTC_1012 4112-3522 18 µM 0.303907762941355 0.388108100643135 no 1302 0.38059908169179 1876 3112398
SGTC_2077 5212015 200 µM 0.303747250706077 0.388165484447715 no 1303 0.380660228401926 1751 780900
SGTC_1518 st038567 90.8 µM 0.303607510727932 0.388215444070512 no 1304 0.380713464403405 1759 77966
SGTC_3032 9089427 49.47 µM 0.303510451972033 0.388250145456817 no 1305 0.38075044169431 1758 17173707
SGTC_3103 9120822 49.47 µM 0.302949500863358 0.388450719599135 no 1306 0.380964173288916 1883 17141819
SGTC_1229 0139-0193 12.2 µM 0.302686460481133 0.388544782784527 no 1307 0.38106440851298 1887 3090752
SGTC_1588 farnesol 29.9 µM 0.30217575744613 0.388727428742318 no 1308 0.381259041846106 1755 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.301312534963336 0.389036204373191 no 1309 0.381588091654685 1765 115019
SGTC_405 ebelactone b 50 µM 0.300838162561415 0.389205917760192 no 1310 0.381768953046485 1775 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_481 bay k-8644 50 µM 0.299133828179029 0.389815841502365 no 1311 0.382418968072702 1742 2303 A calcium channel antagonist.
SGTC_1466 k213-0079 57.5 µM 0.29889201882637 0.389902398928023 no 1312 0.382511218481758 1775 3657981
SGTC_1907 st060210 83.7 µM 0.297266483350704 0.390484412757314 no 1313 0.383131534038149 1868 688793
SGTC_2495 cafestol 54.53 µM 0.296414854021969 0.390789431928364 no 1314 0.383456641448117 1837 16667697 An anti-infammatory.
SGTC_2823 7987624 58.44 µM 0.296351784912402 0.390812023406922 no 1315 0.383480721193173 1794 2239440
SGTC_1228 0124-0032 52.5 µM 0.295657190522676 0.391060852840572 no 1316 0.38374594663372 1855 X1228
SGTC_1811 st050069 61.5 µM 0.294684550184178 0.391409363566355 no 1317 0.384117433266395 1924 3877702
SGTC_1246 0422-0085 105 µM 0.292457936939187 0.392207518287278 no 1318 0.384968258061602 1924 264295
SGTC_977 1348-1378 135 µM 0.289739483350349 0.393182593613061 no 1319 0.386007773978806 1799 X977
SGTC_20 0481-0013 4.944 µM 0.289415114267784 0.393298985642626 no 1320 0.386131865078146 1752 182045
SGTC_2391 6285546 200 µM 0.288387342939054 0.393667839557203 no 1321 0.386525127624191 1756 846083
SGTC_178 4092-0806 87.505 µM 0.288241068476128 0.393720343346287 no 1322 0.386581107018562 1803 2169044
SGTC_2366 9070441 60.58 µM 0.288055094548094 0.393787099660283 no 1323 0.386652282848887 1747 6837235
SGTC_2664 lyso-paf C-16 73.48 µM 0.284468734937114 0.395075050478387 no 1324 0.38802559532181 1826 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1417 3966-0327 90.4 µM 0.283197721964425 0.395531778883613 no 1325 0.388512637258628 1827 651118
SGTC_1366 1683-0113 21.9 µM 0.282944894202461 0.395622647662415 no 1326 0.388609539752561 1777 708623
SGTC_2078 5212016 200 µM 0.28262651820626 0.395737083190824 no 1327 0.388731575089204 1932 1899708
SGTC_1609 st001574 46.4 µM 0.281649763492036 0.396088219229362 no 1328 0.389106039222192 1759 3960012
SGTC_3037 9091026 49.47 µM 0.280218417415689 0.39660292973121 no 1329 0.389654968711897 1862 25236398 YIL048W NEO1
SGTC_516 3992-2719 87.3 µM 0.279529011539582 0.396850903702931 no 1330 0.389919438488355 1694 5350887 YDR037W KRS1
SGTC_664 1222-0054 14.9 µM 0.276877843278296 0.39780489629001 no 1331 0.390936953121047 1814 6813991
SGTC_2561 acetosyringone 100 µM 0.276680152354503 0.397876057674343 no 1332 0.391012856634858 1847 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_3277 9138724 49.47 µM 0.276061001817137 0.398098950828326 no 1333 0.391250606596877 1856 15943418
SGTC_1638 st008370 60.6 µM 0.275122210379987 0.398436977593054 no 1334 0.391611174179779 1819 24207134
SGTC_2147 5545932 89.7195 µM 0.274724188996292 0.398580314535113 no 1335 0.391764072910197 1832 797404
SGTC_18 0111-0177 500 nM 0.273566846857316 0.398997178561848 no 1336 0.392208757359669 1834 721752
SGTC_1111 tnp00062 510.699 nM 0.273114659366541 0.399160083681278 no 1337 0.392382539208745 1935 676306
SGTC_1831 st055328 12 µM 0.272643309400555 0.399329910971654 no 1338 0.392563708305952 1924 1103068
SGTC_2324 6149169 200 µM 0.272444720556519 0.399401468195538 no 1339 0.392640045319201 1908 2888231
SGTC_2348 9022543 33.42 µM 0.270671321863091 0.400040623900873 no 1340 0.393321917768703 1845 3162678 YDL140C RPO21
SGTC_130 0136-0219 337.655 µM 0.270574757005067 0.400075434823447 no 1341 0.393359056408744 1962 234244
SGTC_3284 9108171 64.8615 µM 0.270134017539213 0.40023432824442 no 1342 0.393528576191499 1841 8687505
SGTC_1064 honokiol 6.76 µM 0.266662389572601 0.401486479407793 no 1343 0.394864557175583 1845 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_840 0245-0196 390 µM 0.266599170077848 0.401509290918259 no 1344 0.394888897348582 1911 3827528
SGTC_1898 st060199 18.6 µM 0.266450561767764 0.401562914623922 no 1345 0.394946114732512 1790 688866
SGTC_1293 1000-1278 195 µM 0.264880086147512 0.402129716929024 no 1346 0.395550919758143 1907 678847
SGTC_116 0155-0182 31.788 µM 0.263930272584602 0.402472615304952 no 1347 0.395916824158534 1820 771486
SGTC_203 k066-0004 30.888 µM 0.26146794032703 0.403361906766653 no 1348 0.396865834858282 1991 6795412
SGTC_1277 0873-0036 22 µM 0.260716325960625 0.403633458260254 no 1349 0.397155637537718 1903 5965735
SGTC_2452 5863136 48.41 µM 0.259339442606233 0.404131034228208 no 1350 0.397686674659519 1826 2184096
SGTC_2949 9072542 2.23 µM 0.257441863797486 0.404817032400853 no 1351 0.398418844495407 1799 16457352
SGTC_1450 4112-4260 37.6 µM 0.257259606591711 0.404882936067819 no 1352 0.398489186257163 1953 1633175
SGTC_1171 0368-0077 21.4 µM 0.257020398616605 0.404969437058638 no 1353 0.398581513046035 1841 3239779
SGTC_1900 st060200 72.8 µM 0.256580932834583 0.405128366206644 no 1354 0.398751147868906 1817 688945
SGTC_1267 0828-0272 9.49 µM 0.25640773769472 0.405191005089572 no 1355 0.398818006855819 1960 745334
SGTC_3058 9093861 49.47 µM 0.255815873370651 0.405405080920249 no 1356 0.399046508236113 1902 17217477
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.255599801181811 0.405483240740376 no 1357 0.39912993596839 1969 77254
SGTC_1414 3917-0015 5.4 µM 0.255168466481887 0.405639278764481 no 1358 0.399296492584168 1929 6618702
SGTC_647 0140-0236 81 µM 0.254594757843316 0.405846844684002 no 1359 0.399518054217478 1876 990837
SGTC_504 lovastatin 124 µM 0.251362245731069 0.407016850222719 no 1360 0.400767027171463 1801 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_3244 9134489 49.47 µM 0.251237509005181 0.407062015299105 no 1361 0.400815243174312 1832 16584271
SGTC_2700 st077718 96.8 µM 0.250893510403354 0.407186577825512 no 1362 0.400948220962743 1804 904970
SGTC_1621 st003705 32.4 µM 0.250741937599301 0.407241465596748 no 1363 0.401006817333659 1988 24207032
SGTC_53 0973-0023 39.979 µM 0.249486545312259 0.407696140057645 no 1364 0.40149222360851 2030 674768
SGTC_144 4161-2749 112.381 µM 0.249231803677925 0.407788416866101 no 1365 0.401590739837719 1911 797501 YMR168C CEP3
SGTC_2872 9044037 25.97 µM 0.249127492368906 0.407826203743187 no 1366 0.401631081954385 1939 6465195
SGTC_2943 9068529 45.32 µM 0.247698545463669 0.408343927384926 no 1367 0.402183828679515 1928 3270634
SGTC_1619 st003326 88.7 µM 0.247000276736311 0.408596976312976 no 1368 0.402454004951997 1957 2849032
SGTC_1072 oxiconazole 14.9 nM 0.246989671845663 0.408600819763851 no 1369 0.402458108588304 1887 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2054 5233173 129 µM 0.245773051278592 0.409041808681812 no 1370 0.402928959631878 1906 6889
SGTC_1686 st019653 115.5 µM 0.243736704369206 0.409780181530043 no 1371 0.403717372250201 1979 97252
SGTC_2606 farnesol 9.78 µM 0.241982195986444 0.410416617431706 no 1372 0.404396979435586 1970 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_352 k048-0007 5.11 µM 0.240721322783755 0.410874136388851 no 1373 0.404885555830735 1951 6811911
SGTC_1163 k060-0048 49.9 µM 0.240531167600663 0.410943146412919 no 1374 0.404959252047307 1848 6809982
SGTC_951 1171-0579 82.7 µM 0.239742649710082 0.411229340176008 no 1375 0.405264884630029 1860 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2837 9008476 45.46 µM 0.23942144260212 0.411345936335059 no 1376 0.405389402320201 1911 2992805
SGTC_2723 salbutamol 83.58 µM 0.238172232263147 0.411799466184528 no 1377 0.405873756464645 1971 9884233 β2-adrenoceptor agonist
SGTC_1740 st038286 13.222 µM 0.238004043317918 0.411860536739392 no 1378 0.405938979095415 1914 716786
SGTC_1622 st003707 19.4 µM 0.236629362637849 0.412359772593215 no 1379 0.406472169469047 1905 10140899
SGTC_3311 9131146 2.8755 µM 0.235104494053202 0.412913717333172 no 1380 0.407063815350499 1894 4900406 YPR165W RHO1
SGTC_141 0443-0274 32.331 µM 0.235086400444381 0.412920291309881 no 1381 0.407070836909717 2026 1627241
SGTC_1261 0712-0010 12.7 µM 0.232658816898699 0.41380252942463 no 1382 0.408013175504139 1994 2840123
SGTC_788 1182-0090 188 µM 0.231616783214378 0.414181361531682 no 1383 0.408417835417107 1999 5715185
SGTC_1521 st012942 49.4 µM 0.230912984290122 0.414437273351408 no 1384 0.408691201653239 2034 24207259
SGTC_1023 4482-3888 16 µM 0.230910978907007 0.414438002590666 no 1385 0.408691980638167 1990 3303168
SGTC_2506 ethyl hematommate 54.16 µM 0.229968464678704 0.414780771884388 no 1386 0.409058137276197 1822 3940691 An allergen.
SGTC_3209 9113616 49.47 µM 0.229270853004719 0.415034517935734 no 1387 0.40932920303956 2065 16649353
SGTC_2850 9015429 58.44 µM 0.22739574669916 0.415716735863274 no 1388 0.410058013656191 1867 6457570
SGTC_2929 9013348 24.6 µM 0.22711461109321 0.415819043086034 no 1389 0.410167311442528 1901 2995952
SGTC_2035 5154463 94.595 µM 0.226577907771427 0.416014369034369 no 1390 0.410375986295079 2007 2769623
SGTC_739 1486-1183 203 µM 0.225908397490186 0.416258057365865 no 1391 0.41063633319928 2033 4346692
SGTC_547 1120-0019 610 nM 0.22587086205436 0.416271720466572 no 1392 0.410650930459377 1884 3676939
SGTC_2343 7990716 14.84 µM 0.223744839480069 0.417045768806478 no 1393 0.411477926725578 1951 6456862
SGTC_3342 9147791 14.508 µM 0.223438618266557 0.417157285268093 no 1394 0.411597075461365 1926 1838168
SGTC_2686 alizarin 95.37 µM 0.220784216061161 0.41812421624997 no 1395 0.412630227042556 1866 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_3015 9080845 49.47 µM 0.219962785321335 0.418423543087418 no 1396 0.412950068946861 2011 5296973
SGTC_932 2857-0803 154 µM 0.219939775515589 0.418431928470986 no 1397 0.412959029147735 2014 674898
SGTC_1368 1852-0141 284 µM 0.219489453189947 0.418596045328878 no 1398 0.413134397355596 1912 2838987
SGTC_711 k292-0785 179 µM 0.218931029495732 0.418799578661351 no 1399 0.413351887355572 1936 4146315
SGTC_2195 6536160 144.242 µM 0.218472336012159 0.418966778757065 no 1400 0.413530555195767 1876 3834386
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.218463358518775 0.418970051323255 no 1401 0.413534052239895 1943 6708739 YPR165W RHO1
SGTC_1114 scopoletin 1.73284 µM 0.218199010390002 0.419066416674366 no 1402 0.413637028050796 2033 5280460 A coumarin with genotoxic properties.
SGTC_2502 avocadyne acetate 18.59 µM 0.217327597082038 0.419384115655114 no 1403 0.413976525826037 2020 3952079
SGTC_260 nsc-65238 3.989 µM 0.216581399493642 0.419656205399848 no 1404 0.414267291368511 1987 3246252
SGTC_3332 9141069 11.198 µM 0.216087895602767 0.419836175295353 no 1405 0.414459617370719 1850 17332883
SGTC_636 0kpi-0074 126 µM 0.215185137884602 0.420165434323184 no 1406 0.414811488884212 1912 616434
SGTC_2912 7964298 10.93 µM 0.213804826785063 0.420668977352758 no 1407 0.415349630380337 1897 2975850
SGTC_2091 4-phenylthiadiazole 200 µM 0.212991045183013 0.420965909037986 no 1408 0.415666973672587 1909 270010
SGTC_2241 6772625 37.8075 µM 0.209929036118544 0.422083572893382 no 1409 0.416861529802221 2072 2285411
SGTC_25 0118-0223 35.662 µM 0.207333228331509 0.423031560718405 no 1410 0.417874812724455 2022 5333628
SGTC_1904 st060225 78 µM 0.204977697716538 0.423892185445714 no 1411 0.418794774851784 1921 66595
SGTC_1739 st037196 92.5 µM 0.204412059903082 0.424098903035687 no 1412 0.419015753354749 2071 612214
SGTC_868 0527-0199 213 µM 0.204070282551283 0.424223818867423 no 1413 0.419149288371479 1943 2849450
SGTC_3323 9138564 53.9225 µM 0.202914967475612 0.424646130003424 no 1414 0.419600747645737 2061 43912313 YNL103W MET4
SGTC_1107 amlodipine 47 µM 0.202762663710878 0.424701809225305 no 1415 0.419660270875474 1968 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_3231 9132313 49.47 µM 0.201868802791288 0.42502861721676 no 1416 0.420009645859801 1961 4905967
SGTC_185 k048-0037 25.491 µM 0.201442201913576 0.425184606613359 no 1417 0.420176409561779 2064 6827589
SGTC_2232 chlorophetanol 41.5365 µM 0.198787029876863 0.426155750009648 no 1418 0.421214671087855 2033 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_165 k038-0023 64.381 µM 0.197145640484711 0.426756321422932 no 1419 0.42185678413655 1954 46368543
SGTC_1763 st044482 94.5 µM 0.196258421206678 0.427081018752843 no 1420 0.422203951769604 2006 88505
SGTC_1143 3454-2408 5.08 µM 0.19526590614433 0.427444309926289 no 1421 0.422592393123649 2010 X1143
SGTC_246 cycloheximide 667 µM 0.194998930493845 0.427542041776347 no 1422 0.422696892446465 1959 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2062 5245942 200 µM 0.194177825655654 0.427842651693061 no 1423 0.423018322487536 2072 1376160
SGTC_557 1315-0110 16.2 µM 0.193151337713748 0.428218512119147 no 1424 0.423420223945459 1977 6833801
SGTC_897 1000-0139 31.4 µM 0.192061888818043 0.42861749766533 no 1425 0.423846863709203 2079 6151020
SGTC_1671 st016596 74.5 µM 0.189130707937408 0.429691336244689 no 1426 0.424995187171849 1991 2829167
SGTC_428 3448-4153 16.5 µM 0.1882690107043 0.430007118495451 no 1427 0.425332888408639 1846 3834874
SGTC_2620 irigenin 100 µM 0.187168720900869 0.43041040174264 no 1428 0.425764174266518 2038 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1362 1611-0397 101 µM 0.18671863012944 0.430575392014995 no 1429 0.425940624128239 1961 27816
SGTC_385 1494-0393 12.4 µM 0.184806468589028 0.431276469965878 no 1430 0.426690417028219 2015 3090647
SGTC_1020 4335-0961 93.3 µM 0.184617152530151 0.431345892925508 no 1431 0.426764665717625 1886 669075
SGTC_2869 9037858 32.47 µM 0.184297556836493 0.431463094762082 no 1432 0.426890015231252 2102 27187042
SGTC_2197 6588183 93.1375 µM 0.182430751357606 0.432147808175326 no 1433 0.427622347308803 2003 884136
SGTC_339 3091-4833 71.4 µM 0.181728392671293 0.432405474627942 no 1434 0.427897941423486 2014 3240077
SGTC_1206 3978-0017 132 µM 0.18078097632637 0.432753088162256 no 1435 0.428269747880872 2006 3873677
SGTC_873 0591-4978 488 µM 0.179877294315179 0.433084703774719 no 1436 0.428624450475353 2115 3305145
SGTC_3240 9133527 49.47 µM 0.179151009563236 0.433351255766228 no 1437 0.42890956499942 1987 17617455
SGTC_1949 st076024 69.1 µM 0.178900588209561 0.433443169330728 no 1438 0.429007880456602 1978 2921930
SGTC_1692 fluoroquinolonic acid 71 µM 0.178182995940783 0.433706571196522 no 1439 0.429289631652439 2045 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1456 k015-0012 13 µM 0.177731732915535 0.433872228429251 no 1440 0.42946683136585 2143 2989616
SGTC_2009 4012297 12.05 µM 0.175690655840799 0.434621646047607 no 1441 0.430268488337996 1949 45595307
SGTC_2652 actinonin 100 µM 0.175534351372793 0.434679045723038 no 1442 0.430329890645332 2057 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1648 st011736 69.8 µM 0.17471699271874 0.434979226664563 no 1443 0.430651007447584 2084 2855514
SGTC_58 0957-0393 9 µM 0.174647526467416 0.435004740383714 no 1444 0.430678300865274 1963 6997992
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.174348681405156 0.435114503947317 no 1445 0.430795721413753 2105 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_626 0214-0009 33 µM 0.172866500564702 0.435658971657608 no 1446 0.431378181931939 2067 3437874
SGTC_870 0573-2213 57.6 µM 0.171555321067795 0.436140725060267 no 1447 0.431893567599164 2100 3916321
SGTC_2881 9058953 51.95 µM 0.170594148631497 0.436493939145599 no 1448 0.432271449597845 2083 17122249
SGTC_3242 9133940 49.47 µM 0.170308085273672 0.436599072225877 no 1449 0.432383926511541 2063 17248444
SGTC_230 MPP+ 141.667 µM 0.170150095102634 0.436657138182937 no 1450 0.432446048829803 1962 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_693 4161-2696 114 µM 0.169995167110029 0.436714080026309 no 1451 0.432506968709975 2073 805759
SGTC_205 1486-1330 71.903 µM 0.169713303085431 0.436817678980704 no 1452 0.432617805748965 2019 4118834
SGTC_47 0149-0135 24.25 µM 0.169356454234866 0.436948844778264 no 1453 0.432758136582063 1969 5239155
SGTC_2617 dihydrotanshinone i 20.83 µM 0.169043860039529 0.437063749728753 no 1454 0.432881071238421 1991 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1947 st076332 61.6 µM 0.168153934667684 0.437390902025364 no 1455 0.433231089821642 2107 24208416
SGTC_2927 9011802 47.9 µM 0.167437648864586 0.437654252454334 no 1456 0.433512851890065 1937 43912568
SGTC_609 0986-0026 86.3 µM 0.166488515276422 0.438003254485403 no 1457 0.433886260261717 2028 2848610
SGTC_2116 5511452 16.8835 µM 0.165574492397228 0.438339391690461 no 1458 0.434245911149903 2046 870744
SGTC_2862 9027634 71.43 µM 0.16474988535172 0.438642683884865 no 1459 0.434570425296192 1927 5012562
SGTC_2849 9019321 12.99 µM 0.16468462530203 0.438666688208558 no 1460 0.43459610948631 2029 16489627
SGTC_2569 tetrandrine 100 µM 0.1642792939579 0.438815784544251 no 1461 0.434755640631193 1919 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2807 7945238 51.95 µM 0.163144964109671 0.439233080429874 no 1462 0.435202148890248 2018 17148797
SGTC_1910 st062352 60.4 µM 0.160402883457572 0.440242111816297 no 1463 0.436281859179875 2035 2245730
SGTC_2248 tofa 1.1 µM 0.160265243368857 0.440292770930454 no 1464 0.436336068355471 1999 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1985 st071382 65.5 µM 0.158736591266028 0.440855464404153 no 1465 0.43693820400306 2131 6123237
SGTC_1820 st053765 18.6 µM 0.158540326392956 0.440927717747128 no 1466 0.437015523297188 1983 3690829
SGTC_2493 resveratrol 26.09 µM 0.158223049287142 0.44104452493345 no 1467 0.437140520908304 2024 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2044 5102272 200 µM 0.15790315775145 0.441162299827982 no 1468 0.437266554878792 2041 592666
SGTC_2159 5658611 73.75 µM 0.156072635102785 0.441836345572706 no 1469 0.437987884017535 2135 793844
SGTC_635 k038-0028 24.7 µM 0.156001859810741 0.441862410259363 no 1470 0.438015777627042 2054 4035102
SGTC_1154 4088-0362 150 µM 0.155974510643999 0.441872482308715 no 1471 0.43802655642844 2137 6618304
SGTC_1654 st012436 41.8 µM 0.15585305340526 0.441917212582585 no 1472 0.438074425478966 2111 4323132
SGTC_779 1360-0071 233 µM 0.153529624681515 0.442773026899318 no 1473 0.438990315061085 2162 7566
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.150726743199457 0.443805798478831 no 1474 0.440095638109347 1997 688667
SGTC_3019 9081971 49.47 µM 0.15005309809344 0.444054072177959 no 1475 0.440361361612809 2138 16451803
SGTC_2799 7812892 81.82 µM 0.149448220215623 0.444277020244134 no 1476 0.440599982346875 2119 20205235
SGTC_2158 5657123 3.6195 µM 0.14943103273307 0.444283355526316 no 1477 0.440606763022361 2150 2858827
SGTC_2175 5807670 165.306 µM 0.149141848922269 0.444389950410544 no 1478 0.440720852239882 2127 241186
SGTC_1055 3448-0672 86 µM 0.148865647191864 0.444491763777883 no 1479 0.440829824342613 2059 748378
SGTC_3044 9093193 49.47 µM 0.148169729102309 0.444748309041038 no 1480 0.441104410384464 1990 25236277
SGTC_603 3794-0023 45.9 µM 0.147125141135813 0.445133432392205 no 1481 0.441516623025813 2151 3802260
SGTC_2101 5377231 179.231 µM 0.146052658999628 0.445528893771037 no 1482 0.441939909105393 2096 2844213
SGTC_2330 7979373 200 µM 0.145969531152472 0.445559548161372 no 1483 0.441972720688496 1959 1863007
SGTC_1342 1486-1464 234 µM 0.145509778019463 0.44572909351453 no 1484 0.442154198085724 2063 3253938
SGTC_261 5-fluorouridine 15.376 µM 0.143109795003717 0.44661430712001 no 1485 0.443101734638267 2140 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1737 st035557 69.7 µM 0.14137934332083 0.447252735063597 no 1486 0.443785135996819 2158 5716916
SGTC_954 1189-0853 2.85 µM 0.140826991907874 0.447456546889899 no 1487 0.444003309550482 2179 2828194
SGTC_2264 7948757 110.76 µM 0.140364457393198 0.447627227907664 no 1488 0.444186019342784 2032 2971411
SGTC_182 3448-4371 550.524 µM 0.137367938167826 0.44873321451538 no 1489 0.445369986202866 2218 3491403
SGTC_2897 9048598 12.99 µM 0.136517609099656 0.449047135812518 no 1490 0.445706052411211 2080 6467404
SGTC_3020 9089140 49.47 µM 0.133947823936519 0.449996032539333 no 1491 0.446721916484592 2061 17217859
SGTC_2010 4012422 159 µM 0.133386744333233 0.45020325018078 no 1492 0.446943764109803 2119 952393
SGTC_1481 3346-2004 36 µM 0.132730183108228 0.450445748282471 no 1493 0.447203385692818 2186 2770522
SGTC_1513 0337-0559 19 µM 0.130923599792888 0.451113097383975 no 1494 0.44791787271792 2009 775073
SGTC_1432 4049-0298 68.4 µM 0.130340787480372 0.451328416932367 no 1495 0.448148405775379 2198 741646
SGTC_3106 9121286 49.47 µM 0.130176142472951 0.451389247497344 no 1496 0.448213534749281 2163 15943471
SGTC_1223 0764-0573 147 µM 0.128995391043592 0.451825527167234 no 1497 0.448680647887132 2133 1609797
SGTC_1455 4262-0120 131 µM 0.128447001338107 0.452028173275207 no 1498 0.448897618746718 2138 1529587
SGTC_520 3584-0023 682 µM 0.128232064237508 0.452107602261145 no 1499 0.448982662968464 1993 1340790
SGTC_2930 9013230 14.89 µM 0.127249257282507 0.452470818283777 no 1500 0.449371560271522 2138 2995857
SGTC_2810 7959871 45.46 µM 0.127230375291289 0.452477796892774 no 1501 0.449379032364195 2134 2974535
SGTC_1594 piperine 70.1 µM 0.12646295610371 0.452761440313179 no 1502 0.449682735162246 2053 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_899 1083-0020 478 µM 0.125202689907114 0.453227295618253 no 1503 0.450181543882821 2159 767123
SGTC_503 tyrphostin 8 294 µM 0.125109040612401 0.453261915501874 no 1504 0.450218613080329 2185 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2557 derrustone 83.84 µM 0.124104527056586 0.453633282201877 no 1505 0.450616256900086 2001 629853 An antioxidant.
SGTC_2013 4024628 200 µM 0.123011425797303 0.454037445661445 no 1506 0.451049025103783 2126 5230760
SGTC_999 SEC7.066 22.7 µM 0.122845872646207 0.45409866147456 no 1507 0.451114574109198 2099 740511 YDR170C SEC7
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.122452547511654 0.454244103837044 no 1508 0.451270312346255 2093 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2269 7935389 174.42 µM 0.121436318457677 0.454619909742097 no 1509 0.451672725880324 2144 97605
SGTC_2859 9028643 45.46 µM 0.121162284480073 0.454721255661903 no 1510 0.45178124830254 2145 17151580
SGTC_1081 sertraline 6 µM 0.120306312769086 0.45503783842555 no 1511 0.452120251784624 2199 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1271 0832-2808 169 µM 0.119063817577124 0.455497428393382 no 1512 0.452612398086731 2189 3663794
SGTC_1914 st062367 72.6 µM 0.118783547415477 0.455601106550203 no 1513 0.452723421825747 2109 978205
SGTC_1939 st074455 53.6 µM 0.117245338606058 0.456170177798445 no 1514 0.453332819818602 2206 1644229
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.116395448385878 0.456484639348374 no 1515 0.453669571269345 2184 91467 include heat shock
SGTC_1956 st077085 54 µM 0.115755403361124 0.456721475643027 no 1516 0.453923197898795 2088 24208685
SGTC_1076 itraconazole 331 nM 0.114902299646191 0.457037174077847 no 1517 0.454261281157748 2196 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_317 4495-0002 170 µM 0.114684838294506 0.457117651883471 no 1518 0.454347465957441 2062 15991618
SGTC_2592 piperlongumine 83.33 µM 0.11433547869308 0.457246946097379 no 1519 0.454485929483597 2077 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_857 0438-0306 1.35 µM 0.113958692533083 0.457386395656147 no 1520 0.454635269320582 2120 4686136
SGTC_365 0121-0052 13.6 µM 0.113863584699028 0.457421596148206 no 1521 0.454672966487209 2159 3101739
SGTC_875 0709-0210 25.7 µM 0.113487588842451 0.457560759762819 no 1522 0.454822001090384 2244 6251364
SGTC_691 1548-0686 185 µM 0.112447118479872 0.457945885802732 no 1523 0.455234448527453 2096 46495133
SGTC_1409 3909-8004 61.9 µM 0.112427345076464 0.457953205234245 no 1524 0.455242287267975 2112 2119279
SGTC_301 4119-0100 24.5 µM 0.112101242277466 0.458073919290724 no 1525 0.455371566220532 2110 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_884 0851-0618 334 µM 0.111633109168614 0.458247215718837 no 1526 0.455557159387056 2199 9642473
SGTC_2959 9079155 11 µM 0.111598291582335 0.458260105027155 no 1527 0.455570963340691 2122 16189457
SGTC_1032 k061-1018 98.7 µM 0.110618962029955 0.458622666196877 no 1528 0.455959255122187 2231 4005393
SGTC_946 3434-1334 87.4 µM 0.10999415496354 0.458853996308881 no 1529 0.456207005225607 2164 4047976
SGTC_3179 9107801 49.47 µM 0.108952544664233 0.459239675619339 no 1530 0.456620065024648 2177 4818259
SGTC_2697 mebhydrolin 72.4 µM 0.105493834066194 0.460520613121769 no 1531 0.457991981196221 2191 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1328 1441-0025 69.2 µM 0.105425974961623 0.460545748962578 no 1532 0.45801890293612 2196 4562601
SGTC_271 rotenone 740 µM 0.104802335223469 0.46077676010486 no 1533 0.458266328507951 2166 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_231 b-estradiol 524 µM 0.103434277734118 0.461283567730773 no 1534 0.458809154168073 2121 450 A steroid.
SGTC_406 estrone 100 µM 0.102666444378358 0.461568045223858 no 1535 0.459113853190889 2240 5870 A steroid.
SGTC_194 1486-1323 56.904 µM 0.10235636749305 0.461682932367837 no 1536 0.459236907703913 2098 5178754
SGTC_4 0960-0234 25.671 µM 0.102115608491062 0.461772138623963 no 1537 0.459332455997072 2119 6821112
SGTC_1999 st074831 12.5 µM 0.0999175196957072 0.462586664964335 no 1538 0.460204903624863 2091 17112523
SGTC_2591 skatole 100 µM 0.0991802514769101 0.462859903242905 no 1539 0.46049757728878 2142 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1865 st057639 52.2 µM 0.0969442541881934 0.463688690726199 no 1540 0.46138533226699 2241 688818
SGTC_112 phenothiazine 287.218 µM 0.0945813273977199 0.464564696701351 no 1541 0.462323690957655 2243 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1835 st008666 49.2 µM 0.0937573110072572 0.46487022426037 no 1542 0.462650971565036 2098 690455
SGTC_1490 4089-0339 670 nM 0.0930556837946589 0.465130388877455 no 1543 0.462929661908775 2252 742542
SGTC_844 0330-0132 15.3 µM 0.092445133942185 0.465356793980793 no 1544 0.463172190615319 2231 2828079
SGTC_3269 9137823 49.47 µM 0.0915264526057601 0.465697482018396 no 1545 0.46353714415273 2104 17682936
SGTC_26 0302-0163 425.158 µM 0.0913193407809648 0.465774291807656 no 1546 0.463619425238095 2177 3100915
SGTC_1500 4488-1866 171 µM 0.0911570123846303 0.465834494041629 no 1547 0.463683915915984 2229 2900003
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.0904419266993681 0.466099704964068 no 1548 0.463968020251386 2147 4213774
SGTC_805 3852-0218 479 µM 0.0900711960560058 0.466237207449095 no 1549 0.46411531918854 2179 6615355
SGTC_2109 5483026 200 µM 0.0886189828465136 0.466775866072149 no 1550 0.464692360655391 2167 759335
SGTC_2627 acetyl isogambogic acid 100 µM 0.0866821300603646 0.467494382984213 no 1551 0.465462090545491 2152 6857789 A caspase activator and apoptosis inducer.
SGTC_104 0074-0074 590.992 µM 0.0855219575330692 0.467924824641538 no 1552 0.465923219915919 2265 3943124
SGTC_1628 st004252 77.7 µM 0.0854619188065054 0.467947100947435 no 1553 0.465947084531152 2229 692968
SGTC_1388 3346-4487 254 µM 0.0834121557291852 0.46870768897404 no 1554 0.466761911660704 2198 3345614
SGTC_1361 1608-0041 5.61 µM 0.0824181754267005 0.469076558027151 no 1555 0.467157091659246 2217 X1361
SGTC_253 dyclonine 31.25 µM 0.082264044765191 0.469133758760268 no 1556 0.467218372799384 2259 3180 An oral anasthetic.
SGTC_3117 9124945 49.47 µM 0.0818665062209904 0.469281295588874 no 1557 0.467376434584475 2160 17592065
SGTC_523 1934-0222 13.7 µM 0.0808961100400132 0.469641452366991 no 1558 0.467762286783196 2226 1361595
SGTC_2317 5986382 200 µM 0.0798643949715606 0.470024394523328 no 1559 0.468172554018868 2228 877883
SGTC_733 4069-0007 56.1 µM 0.079223484828485 0.470262295419674 no 1560 0.468427432553089 2271 5717425 YNL287W SEC21
SGTC_198 3454-2873 16.191 µM 0.0787024129674573 0.470455721098114 no 1561 0.468634663082693 2201 710957
SGTC_2369 9071472 200 µM 0.0783467621236407 0.470587745292877 no 1562 0.468776110477514 2220 17296037
SGTC_1038 k292-0204 154 µM 0.0771819833865982 0.471020155336348 no 1563 0.469239387031433 2261 4454212
SGTC_2576 guaiol 23.12 µM 0.0730513728891478 0.472553866577137 no 1564 0.470882618512633 2263 227829
SGTC_776 4476-4378 112 µM 0.0726987961186577 0.472684798835351 no 1565 0.471022903287083 2136 2892008
SGTC_1748 st037455 53.6035 µM 0.0726775236456453 0.472692698636187 no 1566 0.471031367386091 2235 580690
SGTC_1610 st001799 48.1 µM 0.0725820195464245 0.472728165418876 no 1567 0.471069367649629 2164 621897
SGTC_1152 3909-8331 15.9 µM 0.0711996918369567 0.473241536215516 no 1568 0.471619413337265 2216 16001939
SGTC_470 aa-861 153 µM 0.0694168457900898 0.473903717581157 no 1569 0.472328910131195 2186 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1380 2291-0730 164 µM 0.0688490160595745 0.474114635072459 no 1570 0.472554900724512 2189 2999191
SGTC_2567 aureobasidin a 60 nM 0.0685826098182869 0.474213592832284 no 1571 0.472660930812103 2176 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1597 7-benzyloxygramine 47.5 µM 0.068529226171417 0.474233422612211 no 1572 0.472682177817658 2268 260807
SGTC_2744 captopril 92.04 µM 0.0655466117134276 0.475341438457579 no 1573 0.473869397660513 2289 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1221 2958-7315 257 µM 0.064465340399845 0.475743169087548 no 1574 0.474299852019598 2240 4562705
SGTC_375 3970-0961 9.27 µM 0.0639175646497582 0.475946696636559 no 1575 0.4745179331543 2233 2898222
SGTC_1658 st012944 20 µM 0.0637728951035639 0.476000450044202 no 1576 0.474575530443785 2266 24207260
SGTC_264 promethazine 12.5 mM 0.0626808584554543 0.476406221136765 no 1577 0.475010320078001 2304 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2472 5377652 49.4 µM 0.0622799519568358 0.476555193240872 no 1578 0.475169946750057 2159 1610903
SGTC_2844 9010103 25.97 µM 0.0611712914974131 0.476967175326322 no 1579 0.475611396484513 2205 2480525
SGTC_2097 5376186 200 µM 0.0600839124901082 0.477371273067794 no 1580 0.476044401392928 2295 742755
SGTC_817 1391-0715 46 µM 0.0598947180099565 0.47744158494472 no 1581 0.476119743380845 2230 1353946
SGTC_1885 st057546 99.9 µM 0.0587868795696424 0.477853313940359 no 1582 0.476560929486768 2302 702008
SGTC_949 1165-0505 146 µM 0.0581056565382471 0.478106502761139 no 1583 0.476832234371022 2236 6244267
SGTC_2634 4'-methoxyflavone 100 µM 0.0572013649586113 0.478442612662477 no 1584 0.477192395431428 2240 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2221 6807166 181.081 µM 0.0568428615837515 0.478575866567047 no 1585 0.477335185253675 2304 674925
SGTC_413 propylparaben 100 µM 0.0566010585010311 0.478665744912233 no 1586 0.477431495668345 2257 7175 A pharmaceutical preservative.
SGTC_2855 9016525 58.44 µM 0.0563897646871408 0.478744283833001 no 1587 0.477515655289453 2290 43811474
SGTC_1068 loratadine 26.9 µM 0.056368199025649 0.478752299938949 no 1588 0.477524245081062 2205 3957 A H1 histamine antagonist.
SGTC_885 0865-0106 16.8 µM 0.0556003187759942 0.479037731930616 no 1589 0.477830105276453 2282 2793380
SGTC_866 0495-0101 262 µM 0.0555953946742577 0.479039562323994 no 1590 0.477832066675024 2208 635694
SGTC_525 k781-2675 26.7 µM 0.0549887640002608 0.479265063221694 no 1591 0.478073707639238 2316 3651118 YDL195W SEC31
SGTC_1765 st044815 90.4 µM 0.0548185719913333 0.479328329353067 no 1592 0.478141502169913 2212 645695
SGTC_3353 9151644 39.2805 µM 0.0544874392146927 0.47945142410725 no 1593 0.478273407889199 2261 4909158
SGTC_2950 9072895 21.46 µM 0.0528718174511308 0.480052040577267 no 1594 0.478917019697093 2252 17332245
SGTC_1447 4239-0816 81.9 µM 0.0519977669685541 0.480376992722846 no 1595 0.479265236354812 2200 1341554
SGTC_1497 4476-2978 41.3 µM 0.0510405290976824 0.480732887006359 no 1596 0.479646612534729 2272 1528379
SGTC_1256 0570-0116 285 µM 0.0506747855741526 0.480868871937156 no 1597 0.479792334512282 2258 410638
SGTC_563 tetrahydrosecaminediol 614 µM 0.0496006212832993 0.481268263404438 no 1598 0.480220325765325 2309 334274 A psychoactive constituent of the cannabis plant.
SGTC_3087 9117406 49.47 µM 0.0495134585007773 0.481300672751507 no 1599 0.480255056011335 2213 42546093
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.0486508723759261 0.481621410916563 no 1600 0.480598763820752 2311 94937 An inhibitor of serotonin biosynthesis.
SGTC_2399 5884133 200 µM 0.0478915910750255 0.481903746769301 no 1601 0.480901320526245 2278 722445
SGTC_1852 st056254 31.4 µM 0.0469726124307482 0.482245477596767 no 1602 0.481267527770263 2241 442583
SGTC_904 1141-0088 396 µM 0.0465473310146463 0.482403626910385 no 1603 0.481437005124933 2203 1378119
SGTC_2190 6049624 200 µM 0.0462669607499626 0.482507889659601 no 1604 0.481548736299092 2300 2265554
SGTC_2873 9040596 71.43 µM 0.0455799525370701 0.482763376021137 no 1605 0.481822524060301 2180 6463863
SGTC_2774 tamoxifen 10.92 µM 0.0447735496282698 0.483063272208323 no 1606 0.482143904141024 2318 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.0443519304469648 0.483220073564708 no 1607 0.482311938929655 2334 229346 A bile salt which induces apoptosis.
SGTC_390 dec-rvkr-cmk 16.7 µM 0.0433561028450416 0.483590434904094 no 1608 0.482708834814039 2293 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2996 9066192 71.4286 µM 0.0418827253133579 0.484138429201072 no 1609 0.483296093758262 2282 6472854
SGTC_2464 5717415 7.67 µM 0.0415619075626106 0.484257755170962 no 1610 0.483423970173796 2333 5285744
SGTC_2450 5739737 12.93 µM 0.0403321805671667 0.484715156688721 no 1611 0.483914149130646 2279 2262825
SGTC_2250 alverine citrate 130 µM 0.0395816195759462 0.484994340556406 no 1612 0.484213340703961 2322 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1704 st028805 70.8 µM 0.037991938040568 0.48558567363734 no 1613 0.484847054950433 2267 2876101
SGTC_2045 5106652 78.05 µM 0.0376436334843798 0.485715240977372 no 1614 0.484985909034633 2327 673349
SGTC_310 1273-0058 1.06 µM 0.0376422665947057 0.485715749455638 no 1615 0.484986453958503 2316 2734232
SGTC_2518 prenyletin 46.28 µM 0.0371064883983893 0.485915058885932 no 1616 0.485200049299576 2335 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2908 7930301 100 µM 0.0368975983757198 0.485992766907528 no 1617 0.485283327331793 2349 2223178
SGTC_1650 st011916 45.8 µM 0.0355090465090585 0.486509327782897 no 1618 0.485836916427358 2338 242528
SGTC_3232 9132874 49.47 µM 0.0354461060747623 0.48653274305484 no 1619 0.485862010230508 2338 3784940
SGTC_426 0988-0037 14.6 µM 0.0353961069552089 0.486551343896689 no 1620 0.485881944484052 2348 5383008
SGTC_2353 9059630 146.67 µM 0.0343919845519445 0.486924907054654 no 1621 0.486282287546657 2314 4779114
SGTC_1769 st044406 64.4 µM 0.033656081503235 0.487198692003493 no 1622 0.48657570049876 2316 670903
SGTC_2290 7904846 200 µM 0.0323228513480048 0.487694721464932 no 1623 0.487107292991765 2322 2962154
SGTC_3137 9097352 49.47 µM 0.031295348616844 0.488077017795926 no 1624 0.4875169999294 2322 44120435
SGTC_1059 3448-6867 171 µM 0.0312873332841273 0.488080000052726 no 1625 0.487520196019406 2367 3934407
SGTC_1573 oleylamine 1.06 µM 0.0304847407779809 0.488378623187882 no 1626 0.487840231410599 2321 5356789 An amine of the fatty acid oleic acid.
SGTC_1891 st059073 26.2 µM 0.0304395137918378 0.488395451131312 no 1627 0.487858265998125 2357 688754
SGTC_529 4076-0302 30.3 µM 0.0303259507284883 0.488437705481743 no 1628 0.48790355019958 2290 5816522
SGTC_408 cantharidin 100 µM 0.0282394329421977 0.489214076061023 no 1629 0.488735593407434 2279 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2488 5268135 45.7 µM 0.0275264695515735 0.48947937150248 no 1630 0.489019914096993 2331 1270356 YLR208W SEC13
SGTC_445 e6 berbamine 66 µM 0.0272311633121485 0.489589257054689 no 1631 0.489137680094194 2330 6610268 A calcium/calmodulin antagonist.
SGTC_312 4092-0653 6.84 µM 0.0270978611605195 0.48963885999285 no 1632 0.489190840341131 2313 1148278
SGTC_768 0384-0033 77.3 µM 0.0264823074456034 0.489867915172817 no 1633 0.489436322631809 2326 3965305 YMR134W ERG29
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.0263546297831437 0.489915426037184 no 1634 0.489487240877666 2361 1273210
SGTC_2650 prasterone 100 µM 0.0259348120291736 0.490071647825068 no 1635 0.489654666697119 2355 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1046 2001-0062 216 µM 0.0258398361304885 0.490106990288813 no 1636 0.48969254390481 2344 739778
SGTC_1790 st045711 43.5 µM 0.0246458284359361 0.490551311373648 no 1637 0.490168732291085 2357 585119
SGTC_3289 9119912 71.43 µM 0.0241726171897637 0.490727408768658 no 1638 0.490357460031657 2342 17014829
SGTC_3056 9094900 49.47 µM 0.0241699022931806 0.490728419075794 no 1639 0.49035854280234 2358 25236784
SGTC_1311 1190-0148 100 µM 0.0233335636849115 0.491039652465461 no 1640 0.490692099523773 2351 1961333
SGTC_3162 9099653 49.47 µM 0.0231722516953585 0.491099683422533 no 1641 0.490756436300946 2369 25237511
SGTC_353 1988-1175 58.3 µM 0.0231681042542999 0.491101226861967 no 1642 0.49075809044646 2324 2788357
SGTC_1502 4534-4282 27.7 µM 0.0208297351857479 0.491971454095115 no 1643 0.491690738816605 2361 3278949
SGTC_300 r073-0011 5.04 µM 0.0207922383128109 0.491985408929805 no 1644 0.491705694665583 2366 2735780
SGTC_1127 asiatic acid 681.4 nM 0.0200849423409229 0.492248637988133 no 1645 0.491987805997468 2362 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2119 5528445 120.635 µM 0.0200107045697577 0.492276266702591 no 1646 0.492017416632101 2356 791935
SGTC_2836 9010338 19.48 µM 0.0193005414506596 0.492540566550627 no 1647 0.492300675997345 2370 2994051
SGTC_1938 st074717 56.4 µM 0.0177968041138966 0.493100219838019 no 1648 0.492900477152448 2377 17250979
SGTC_1340 1486-1359 257 µM 0.0165807136023242 0.493552828182512 no 1649 0.493385555380117 2293 4309068
SGTC_1824 st053723 68.6 µM 0.016309014293721 0.493653951230205 no 1650 0.493493933066069 2353 675225
SGTC_1119 parthenolide 318.541 nM 0.01534434552862 0.494012991998499 no 1651 0.493878732012164 2359 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_3234 9132280 49.47 µM 0.0151427403720219 0.494088028190564 no 1652 0.493959151489039 2342 17612295
SGTC_2447 5741742 33.78 µM 0.0140385379685204 0.494499009134114 no 1653 0.494399617604346 2365 1776504
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.0135931087926337 0.494664798263429 no 1654 0.494577301175402 2379 2374 Ca(2+)-ATPase inhibitor.
SGTC_1090 efavirenz 20.7 µM 0.0124711935626131 0.495082380113756 no 1655 0.495024842566065 2332 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1172 0370-0043 85 µM 0.0119722419051562 0.495268093903394 no 1656 0.495223880610287 2364 376585
SGTC_856 0433-0016 11.3 µM 0.0117500027294921 0.495350813431049 no 1657 0.495312534977195 2359 3911780
SGTC_459 nigericin 15.3 µM 0.0102683676296729 0.495902296995871 no 1658 0.495903585989166 2368 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1712 st032288 53.4 µM 0.0099048790109086 0.49603759335305 no 1659 0.496048589590319 2378 2883011
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.00865753837832703 0.496501877129328 no 1660 0.496546185042356 2383 3256 An antibiotic and ribosome inhibitor.
SGTC_379 3970-0972 5.9 µM 0.00836825129376914 0.496609555953794 no 1661 0.49666158970943 2382 2898042 YBL034C STU1
SGTC_2541 muurolladie-3-one 83.07 µM 0.00791992513488357 0.49677643299983 no 1662 0.496840440036795 2383 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1635 st007035 42.4 µM 0.00765111252948436 0.496876491349643 no 1663 0.496947677500159 2390 3716403
SGTC_2821 7996764 71.43 µM 0.00618675544012471 0.497421562653944 no 1664 0.497531857421521 2393 2987135
SGTC_3203 9113543 49.47 µM 0.00452933909389681 0.49803850132349 no 1665 0.49819306131137 2389 17018012
SGTC_451 chloral hydrate 100 µM 0.00445134911519441 0.498067531593691 no 1666 0.498224174497642 2395 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2416 tofa 880 nM 0.00423221092872805 0.498149101624906 no 1667 0.49831159716129 2391 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3263 9137018 49.47 µM 0.00378913172868889 0.498314029681433 no 1668 0.498488358764653 2391 43844957
SGTC_2695 st077686 51.995 µM 0.00344158684874766 0.498443397053175 no 1669 0.498627008204766 2394 2876092
SGTC_619 1652-1634 108 µM 0.00241351803098988 0.498826078207666 no 1670 0.499037146547708 2392 5400454
SGTC_2962 9082311 13.18 µM 0.00158362708657802 0.4991349918195 no 1671 0.499368224462844 2397 16459453
SGTC_2589 lobaric acid 100 µM 0.000835949270470506 0.499413303360481 no 1672 0.49966650453058 2402 73157 A novel microtubule depolymerizer.
SGTC_1977 st070720 65.3 µM 0.000827662359484935 0.499416388037196 no 1673 0.499669810528603 2398 682188
SGTC_3255 9139072 49.47 µM 0.000809855968483255 0.49942301619584 no 1674 0.499676914248453 2398 17646060
SGTC_2463 5473429 200 µM 0.000750903288427124 0.499444960436865 no 1675 0.499700432957906 2402 5399405
SGTC_791 1348-1292 225 µM 0.000410546298823787 0.499571653194875 no 1676 0.499836215727938 2403 5437054
SGTC_2113 5491891 107.031 µM -2.74159579255848e-05 0.499734678103802 no 1677 0.499989062615227 2406 789979
SGTC_2133 5320837 200 µM -0.000589800103480362 0.499944017263738 no 1678 0.499764703815378 2408 2841355
SGTC_928 2764-0428 58.7 µM -0.000890592372804174 0.499944017263738 no 1679 0.499644705094853 2412 662578
SGTC_2596 sinensetin 100 µM -0.00103321708045319 0.499890927327217 no 1680 0.499587806095113 2412 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_314 1671-0008 2.74 µM -0.00159837407585101 0.499680556028345 no 1681 0.499362341272761 2411 3913060
SGTC_1678 st019265 80.2 µM -0.00208973144000403 0.499497655616385 no 1682 0.499166318380676 2409 5367020
SGTC_70 0141-0289 43.283 µM -0.00292643431414283 0.499186205779754 no 1683 0.498832523287653 2422 352408
SGTC_522 1273-0010 11.6 µM -0.0031745101101519 0.499093863449014 no 1684 0.498733555824601 2441 5705015
SGTC_1705 st027868 56.3335 µM -0.00351044114282557 0.498968818460359 no 1685 0.498599539481625 2417 292948
SGTC_421 streptovitacin 30 mM -0.00355406167845969 0.49895258141631 no 1686 0.498582137514229 2450 91467 include heat shock
SGTC_796 1234-0020 70.7 µM -0.00391920932127421 0.498816661139477 no 1687 0.498436465698702 2413 46495034
SGTC_1029 k015-0030 64.7 µM -0.0040856807631454 0.498754694894835 no 1688 0.498370053734084 2433 2208316
SGTC_1137 ixabepilone 100 µM -0.00479339466520992 0.498491260437494 no 1689 0.498087719524361 2418 154225 A novel microtubule stabilizer.
SGTC_2132 5317594 122.667 µM -0.00559727661718783 0.498192029864353 no 1690 0.497767021361994 2419 794577
SGTC_376 3970-0862 59.1 µM -0.00576601097752116 0.498129221662321 no 1691 0.497699707178076 2419 3135186
SGTC_2636 apigenin dimethyl ether 100 µM -0.00659472153347732 0.497820750397957 no 1692 0.497369105822588 2429 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2974 9094440 9.66 µM -0.00708023516177101 0.497640028057803 no 1693 0.497175418438056 2471 25236134
SGTC_1750 st081859 2.357 µM -0.00731898101072104 0.497551160061341 no 1694 0.497080175093337 2421 5291695
SGTC_2242 6630449 61.2675 µM -0.00750672807503442 0.497481275348391 no 1695 0.497005276909342 2497 691249 YDR170C SEC7
SGTC_2833 9001315 45.46 µM -0.00787218471513896 0.497345242380296 no 1696 0.496859485114996 2436 2989378
SGTC_1268 0828-0275 2.46 µM -0.00934286608724905 0.496797817786255 no 1697 0.496272789921911 2445 745337
SGTC_3017 9080681 49.47 µM -0.00953565708935803 0.496726056551499 no 1698 0.49619588086637 2434 16451914
SGTC_1155 4088-0394 48.2 µM -0.0103990676340922 0.496404676667611 no 1699 0.495851447015315 2422 2326248
SGTC_2235 salicylic acid 500 µM -0.0105179618772138 0.496360421863767 no 1700 0.49580401766886 2422 338 A COX inhibitor and kinase inhibitor.
SGTC_2526 patulin 37.61 µM -0.0106201015756016 0.496322403470714 no 1701 0.495763272100477 2437 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_16 erodoxin 22.806 µM -0.0107367919162672 0.496278969084968 no 1702 0.495716722044006 2435 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_618 k072-0232 33.2 µM -0.0114636109548124 0.496008434094015 no 1703 0.495426781068724 2431 5872756 YGL099W LSG1
SGTC_570 0987-0065 62.6 µM -0.0118757791811733 0.495855018547036 no 1704 0.495262360933649 2425 3104428
SGTC_1801 st050089 28.441 µM -0.0127814567611287 0.495517913181448 no 1705 0.494901075324754 2419 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_416 estradiol valerate 100 µM -0.013143175621719 0.495383277441755 no 1706 0.4947567825011 2442 13791 A steroid.
SGTC_1629 st005085 44.9 µM -0.0135095701610898 0.495246901899145 no 1707 0.494610625207629 2426 24207091
SGTC_2448 5185112 27.17 µM -0.0136153151311892 0.495207542715158 no 1708 0.494568442947814 2442 5718189
SGTC_2889 9059656 51.95 µM -0.0145306709068987 0.494866841442483 no 1709 0.494203304999437 2443 3949838
SGTC_44 0929-0055 61.211 µM -0.0145565382837969 0.49485721349263 no 1710 0.494192986500434 2415 1379590
SGTC_894 0960-0238 55.9 µM -0.0150123686209326 0.494687551961098 no 1711 0.49401115638114 2419 6741907 YDL195W SEC31
SGTC_77 0828-0286 12.516 µM -0.0155139698656306 0.494500855460848 no 1712 0.493811069746708 2434 745345
SGTC_2358 9037157 4 µM -0.0164710841227605 0.494144619924084 no 1713 0.493429285242834 2456 2388925
SGTC_3045 9092950 49.47 µM -0.0167064308958615 0.494057025147073 no 1714 0.493335408382433 2434 44120432
SGTC_1305 1181-0477 144 µM -0.0168905796696724 0.493988486183958 no 1715 0.493261954015547 2450 6252086
SGTC_2751 anetholtrithion 17.25 µM -0.0179221779745078 0.493604535415101 no 1716 0.492850468194726 2448 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2521 angolensin 13.4 µM -0.0185926242992695 0.49335500502454 no 1717 0.492583043388477 2473 821428 A flavenoid.
SGTC_1074 carmofur 3.8 µM -0.0190443661714942 0.493186874716943 no 1718 0.49240285636551 2431 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2681 menadione 3.18 µM -0.0193732498227373 0.49306447081841 no 1719 0.492271674976063 2458 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1375 2910-0797 186 µM -0.0210949945798821 0.492423682876546 no 1720 0.491584938877219 2457 742508
SGTC_303 1348-1668 34.2 µM -0.0223845796082734 0.491943746091006 no 1721 0.491070590480459 2457 5380509
SGTC_2746 daunorubicin 9.88 µM -0.0228189246409666 0.491782101210693 no 1722 0.490897356137095 2435 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.0230723337915426 0.491687793647081 no 1723 0.490796287122976 2435 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_3276 9139060 49.47 µM -0.0231293760612293 0.49166656512681 no 1724 0.490773536621038 2448 4870619
SGTC_3335 9143315 29.6265 µM -0.0234217701235012 0.49155774982021 no 1725 0.490656919860453 2459 4899691
SGTC_806 3966-4455 5.86 µM -0.0237300164427265 0.491443035730202 no 1726 0.490533981542127 2459 714982
SGTC_720 r052-1644 49.9 µM -0.0253849044399363 0.490827180303848 no 1727 0.489873975870445 2484 1422863 YOR257W CDC31
SGTC_1789 tunicamycin 25 nM -0.0258065103667448 0.490670285933458 no 1728 0.48970583452892 2504 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_6 0844-0013 19.835 µM -0.0264523897445578 0.490429934344298 no 1729 0.489448253887911 2454 1584900
SGTC_122 0236-0016 402.397 µM -0.0264680927260327 0.490424090824652 no 1730 0.489441991497345 2455 6808838
SGTC_1335 1486-0900 202 µM -0.0277971819975385 0.489929507020726 no 1731 0.488911956767909 2459 X1335
SGTC_968 1309-0633 340 µM -0.0283000146850838 0.489742395742693 no 1732 0.488711434444356 2449 3761976
SGTC_1955 wogonin 32.4 µM -0.0290304848410641 0.489470581320041 no 1733 0.488420138723969 2570 5281703 A flavanone.
SGTC_917 harmaline 728.087 nM -0.0302712435562552 0.489008895274342 no 1734 0.487925365188189 2499 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1878 temozolomide 1 mM -0.0304326486231709 0.488948837553687 no 1735 0.487861003535909 2445 5394 DNA alkylating agent.
SGTC_483 fpl-64176 144 µM -0.0305496105441985 0.488905316979928 no 1736 0.487814364166001 2458 3423
SGTC_1102 cgs 12066b 26.1 µM -0.0312328408115921 0.488651095244417 no 1737 0.487541924751484 2507 6438352 A 5-HT1B full agonist.
SGTC_726 3448-4391 34.2 µM -0.0318128383392462 0.48843528877971 no 1738 0.487310654152538 2499 1356692
SGTC_3131 9127911 49.47 µM -0.0320798065270138 0.488335955937326 no 1739 0.487204203589086 2527 45595681
SGTC_643 k048-0106 28.4 µM -0.0321772896164151 0.488299684858069 no 1740 0.487165333529978 2520 6763920
SGTC_3346 9158254 43.5805 µM -0.0331504405563673 0.487937604489548 no 1741 0.486777309542189 2490 17639500
SGTC_1120 ficusin 1.78878 µM -0.0344909123979201 0.487438871336824 no 1742 0.486242844447109 2556 6199 A DNA cross-linker.
SGTC_2659 sanguinarine 24.21 µM -0.034800129838039 0.487323827302007 no 1743 0.486119558549886 2471 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_125 0133-0007 11.75 µM -0.0349820671046729 0.487256138218873 no 1744 0.486047020249041 2497 26541
SGTC_2008 4012253 172 µM -0.035274155105524 0.487147468733532 no 1745 0.485930565869919 2490 603940
SGTC_2385 9074692 200 µM -0.0356084663850557 0.487023091517226 no 1746 0.485797278702718 2474 17046906
SGTC_333 3486-0131 40.1 µM -0.0359381002600379 0.486900455718977 no 1747 0.485665857931846 2539 6744690
SGTC_2690 usnic acid 100 µM -0.0366358606918083 0.486640867544448 no 1748 0.485387675007944 2497 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_151 3013-0144 2.285 µM -0.0371365210994414 0.486454610075337 no 1749 0.485188076237651 2556 906558 YHR107C CDC12
SGTC_49 0717-0965 32.132 µM -0.0379318442446995 0.48615873721591 no 1750 0.484871011638118 2685 5889349 YGL099W LSG1
SGTC_2226 7298446 200 µM -0.0383025935377477 0.486020815176043 no 1751 0.484723211480626 2483 3283010
SGTC_2376 9072922 81.32 µM -0.0383126839656592 0.486017061470268 no 1752 0.48471918893488 2578 17087968
SGTC_2364 9055074 200 µM -0.0390474483755747 0.485743727611936 no 1753 0.484426279552017 2495 6470630
SGTC_978 1416-0512 87.4 µM -0.0392343471869432 0.485674201936544 no 1754 0.48435177480698 2506 6814003
SGTC_452 diindolylmethane 8 µM -0.0398578580376124 0.485442261338331 no 1755 0.484103224399663 2513 3071 Inhibits expression of several cancer promoting factors.
SGTC_2622 2-methoxyxanthone 59.94 µM -0.0408809018222883 0.485061708679451 no 1756 0.483695421428012 2523 71034 A hepatoprotective.
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.0426159866033753 0.484416321719507 no 1757 0.483003825800406 2624 6710655
SGTC_1188 1403-0014 4.57 µM -0.0432267093312885 0.484189165221957 no 1758 0.482760407007892 2492 9614867
SGTC_280 3448-3607 3.04 µM -0.0439984637960977 0.483902120798509 no 1759 0.482452814198201 2477 626179
SGTC_2991 9074669 71.4286 µM -0.0440635939987759 0.483877896813651 no 1760 0.482426856181638 2518 17333109
SGTC_639 0833-0042 114 µM -0.0442074903120799 0.483824377429056 no 1761 0.482369505743308 2503 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1178 0988-0033 191 µM -0.0448468548566592 0.483586581983666 no 1762 0.482114688932182 2551 5392207
SGTC_3317 9138495 8.753 µM -0.0449373505245921 0.483552924882179 no 1763 0.482078622744489 2477 17020139
SGTC_668 1682-0499 62.6 µM -0.0459418935309889 0.483179323697715 no 1764 0.481678281601027 2519 682214
SGTC_2257 7960413 200 µM -0.0459671300378726 0.483169938137171 no 1765 0.481668224316603 2535 2974689 YIL048W NEO1
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.0462705444458262 0.483057097804473 no 1766 0.481547308140809 2501 165506
SGTC_2041 5107442 45.335 µM -0.0464514779488277 0.482989808973325 no 1767 0.481475203646929 2487 793005
SGTC_3 0833-0587 95.581 µM -0.046872584387189 0.482833202156345 no 1768 0.481307389279739 2423 5382644
SGTC_2424 5537928 59.2 µM -0.0472641956093319 0.482687566799781 no 1769 0.481151331969806 2503 5382802
SGTC_1134 3477-0009 42.5 µM -0.0477419896818654 0.482509884240444 no 1770 0.480960934655929 2530 3973534
SGTC_1205 4161-2785 76 µM -0.0478875594058803 0.482455750308044 no 1771 0.48090292708622 2617 3498106
SGTC_3004 9076122 71.4286 µM -0.04870105785652 0.482153235485328 no 1772 0.480578766415143 2510 44782551
SGTC_3291 9121177 71.43 µM -0.051252184480671 0.48120461812229 no 1773 0.479562284624694 2536 17015612
SGTC_3329 9141233 27.5565 µM -0.052987280497322 0.48055949611453 no 1774 0.478871021084729 2560 4909101 YNL103W MET4
SGTC_2095 5432005 200 µM -0.0533897863793421 0.480409848553769 no 1775 0.478710671448026 2518 783734
SGTC_705 1124-0212 310 µM -0.0542761948658967 0.480080300729875 no 1776 0.478357557667709 2511 9554485
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.0547922415880327 0.479888451789261 no 1777 0.478151990717343 2534 23847180
SGTC_1282 0886-0010 32.4 µM -0.0555698903526293 0.479599356758146 no 1778 0.477842225722294 2513 2836211 YNL267W PIK1
SGTC_2989 9073649 71.4286 µM -0.0562584982607852 0.47934337208878 no 1779 0.477567940016838 2500 21367202
SGTC_3029 9088683 49.47 µM -0.0567864074384583 0.479147131694723 no 1780 0.477357670879126 2600 25236615
SGTC_2466 5983409 37.09 µM -0.0571103477978251 0.479026715405441 no 1781 0.47722864676393 2558 2879657
SGTC_2475 5812728 15.03 µM -0.0580612759467228 0.478673244031831 no 1782 0.476849909824506 2489 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_709 3807-1509 243 µM -0.0582351311570591 0.478608621774929 no 1783 0.476780668788893 2493 1886677 YPL242C IQG1
SGTC_2539 epi(13)torulosol 80 µM -0.0588472602565547 0.47838109690669 no 1784 0.476536882708123 2576 6708597
SGTC_2665 lovastatin 100 µM -0.0589650316579592 0.478337322759519 no 1785 0.476489980161711 2526 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_75 0159-0059 199.013 µM -0.0589874821329214 0.478328978230265 no 1786 0.476481039280643 2514 5377270
SGTC_2236 dapsone 200 µM -0.0590975261109063 0.478288076551849 no 1787 0.476437214538658 2510 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.059439457563098 0.478160987275646 no 1788 0.476301043004759 2570 5377381
SGTC_1960 st011366 51.8 µM -0.0597149116953276 0.478058607941909 no 1789 0.476191347557055 2513 3972846
SGTC_3351 9150312 21.596 µM -0.0600126586185218 0.477947944570252 no 1790 0.476072776371596 2508 4904905
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.0611659700162187 0.47751931032849 no 1791 0.475613515480426 2588 616764
SGTC_351 caspofungin 25 nM -0.0622588057226229 0.477113176182577 no 1792 0.475178366537362 2546 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_736 0958-0254 92.6 µM -0.063217974945214 0.476756736526686 no 1793 0.474796465736047 2578 6812352
SGTC_1201 1889-3372 45.9 µM -0.0640363996658313 0.476452614035089 no 1794 0.47447062176521 2572 5392199
SGTC_941 3237-0776 460 µM -0.0643227600817175 0.476346207181178 no 1795 0.474356615527118 2570 760008
SGTC_34 0469-0683 81.75 µM -0.065738410207655 0.475820199639529 no 1796 0.473793045807045 2590 3690923
SGTC_802 4112-3352 742 µM -0.0660506841273966 0.475704174889485 no 1797 0.473668736711794 2662 704594
SGTC_854 0422-0053 192 µM -0.0665965586988687 0.475501361238633 no 1798 0.473451442712979 2535 3596728
SGTC_1672 st016598 6.51 µM -0.0670054237127961 0.475349456126099 no 1799 0.473288692704055 2595 4665860 YNL267W PIK1
SGTC_2354 9060492 162 µM -0.0672575064598555 0.475255801919242 no 1800 0.473188352591347 2566 6471895
SGTC_2461 5755302 26.15 µM -0.0688643056282002 0.474658873532835 no 1801 0.472548815511977 2549 2788904
SGTC_683 panaxydol 45 µM -0.0704897526000439 0.474055075340284 no 1802 0.471901928251552 2606 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1840 st055363 71 µM -0.0720507860949418 0.473475260641485 no 1803 0.471280745690581 2580 676033
SGTC_1236 0330-0013 258 µM -0.0740106964770524 0.472747370800159 no 1804 0.470500937023658 2570 4617066
SGTC_15 0266-0086 27.098 µM -0.0764505066591918 0.47184137870507 no 1805 0.469530344320067 2545 1712902 YIL048W NEO1
SGTC_2048 5246248 200 µM -0.0767187625407879 0.471741774142638 no 1806 0.469423639090631 2562 677046
SGTC_1150 3909-7983 10.9 µM -0.0772352212273275 0.471550015793552 no 1807 0.46921821141571 2562 23965914
SGTC_646 4092-0839 27.3 µM -0.0778143747857168 0.471334987020639 no 1808 0.46898785584811 2602 877796
SGTC_1291 0993-0025 5.79 µM -0.0785008688626543 0.471080115569176 no 1809 0.468714819552415 2611 4353356
SGTC_1077 5-fluorocytosine 377 nM -0.0787358126212923 0.470992891811862 no 1810 0.468621379768799 2617 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.08040481407077 0.470373309020234 no 1811 0.467957649114402 2631 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_467 ro 31-8220 72.8 µM -0.0811653079884936 0.470091014837848 no 1812 0.467655244336614 2613 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1794 st048918 76.9 µM -0.0836197350147123 0.469180038524425 no 1813 0.466679387808097 2530 672303
SGTC_27 0485-0001 32.618 µM -0.0836954478881861 0.469151939746907 no 1814 0.466649288253465 2547 2054479
SGTC_2520 obtusaquinone 4.71 µM -0.086179153215601 0.468230265951674 no 1815 0.465662001184791 2635 5967872
SGTC_746 1095-0025 46.6 µM -0.0867439135797034 0.468020713613992 no 1816 0.465437534979625 2602 6749286
SGTC_2026 5148700 152 µM -0.0890432653569189 0.467167639350086 no 1817 0.464523762938058 2573 79838
SGTC_407 eburnamonine 100 µM -0.0894469888745066 0.467017870785131 no 1818 0.464363340689109 2561 3195
SGTC_2788 5282734 71.43 µM -0.0898431324790374 0.466870918665154 no 1819 0.464205936000235 2644 743706
SGTC_1736 st036774 51 µM -0.0911287823012712 0.466394029475634 no 1820 0.463695131409231 2742 1272247
SGTC_874 0599-0792 117 µM -0.092016700172282 0.466064700082561 no 1821 0.463342385532454 2559 765305
SGTC_94 0334-0113 514.748 µM -0.0926514087664516 0.465829300425342 no 1822 0.463090250535042 2573 6795178
SGTC_991 3996-0057 64.7 µM -0.093247082756666 0.465608388729769 no 1823 0.462853635335234 2640 715343
SGTC_1841 st054148 70 µM -0.0940018569463349 0.465328488353679 no 1824 0.462553840820054 2624 675442
SGTC_255 tunicamycin 200.472 nM -0.094208829588178 0.465251737633143 no 1825 0.462471635487183 2626 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_773 4358-1457 44.6 µM -0.0970296730308274 0.464205827182299 no 1826 0.461351414975861 2569 1186886
SGTC_2670 beta-carotene 100 µM -0.0971510200168123 0.464160839724201 no 1827 0.461303232167088 2578 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_147 4466-0538 29.23 µM -0.0974681398408066 0.464043274776185 no 1828 0.461177317229356 2753 6742687 YHR072W ERG7
SGTC_2586 curcumin 80 µM -0.0977668382347318 0.463932542024636 no 1829 0.461058720225416 2659 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1868 st057644 42.7 µM -0.0978132767598 0.463915326696833 no 1830 0.461040282305381 2569 688665
SGTC_270 tamoxifen 5.46 µM -0.0982726631506556 0.463745030202226 no 1831 0.460857892367282 2591 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_464 bw-b 70c 158 µM -0.0996648936262499 0.463228965125579 no 1832 0.460305186278057 2711 5353454
SGTC_1359 1582-0056 520 nM -0.100461858135606 0.462933578071989 no 1833 0.459988831199677 2678 3661189
SGTC_1567 st069303 68.4 µM -0.101983237306047 0.462369750733333 no 1834 0.459384990198208 2669 5581319
SGTC_1734 st037168 69.4 µM -0.101984943962304 0.462369118284033 no 1835 0.459384312872393 2686 708907
SGTC_1909 st060837 51.5 µM -0.102432940956611 0.462203103739394 no 1836 0.459206519037548 2641 678937
SGTC_1863 st057641 20.1 µM -0.102600877795014 0.462140872968509 no 1837 0.459139873069253 2585 3921635
SGTC_2666 tannic acid 100 µM -0.103340807708175 0.461866695174411 no 1838 0.458846244553429 2616 16134267 A thiamine antagonist.
SGTC_1026 k007-1105 30.6 µM -0.104392489102243 0.461477030444435 no 1839 0.45842894147234 2588 7066794
SGTC_785 1270-0111 65.3 µM -0.105736916300668 0.460978952626098 no 1840 0.457895544773416 2583 6741994
SGTC_1260 0700-1617 7.75 µM -0.10621605252583 0.460801458975865 no 1841 0.457705467460096 2664 2853078
SGTC_1923 st058458 19.1 µM -0.106597077884706 0.460660315584435 no 1842 0.457554318443676 2724 3534982
SGTC_3081 9117243 49.47 µM -0.10690332126936 0.460546877304296 no 1843 0.457432839150603 2775 45595589
SGTC_290 2043-6722 48.1 µM -0.106993297466741 0.460513549046982 no 1844 0.457397148539573 2644 773758 YLR208W SEC13
SGTC_2819 7996655 46.38 µM -0.107165779897774 0.460449660271826 no 1845 0.457328731368379 2665 6456960
SGTC_472 calcifediol 10 µM -0.108219955355712 0.46005920809257 no 1846 0.456910607916628 2669 5283731 A vitamin D metabolite.
SGTC_1089 terbinafine 2.25 µM -0.109292434059036 0.459662016164879 no 1847 0.4564852736974 2708 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3340 9146634 11.102 µM -0.109582146672552 0.459554728139208 no 1848 0.45637038513375 2655 4907387
SGTC_160 3453-0671 289.699 µM -0.111452525334083 0.458862150082401 no 1849 0.455628755135476 2626 5322268
SGTC_1529 apigenin 74 µM -0.111573402909082 0.458817394885772 no 1850 0.455580830860901 2723 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2227 7312221 64.1025 µM -0.111749048445175 0.458752362657683 no 1851 0.455511193911017 2611 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2519 cryptotanshinone 88.04 µM -0.111776060983568 0.458742361445002 no 1852 0.455500484561189 2634 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1854 st056233 32.9 µM -0.113293794786171 0.458180472740044 no 1853 0.454898818305515 2591 5393174
SGTC_2964 9083345 53.42 µM -0.114039901482144 0.457904282979865 no 1854 0.454603081472329 2647 17741579
SGTC_2529 gangaleoidin 93.61 µM -0.115357798687785 0.45741648062835 no 1855 0.454080763679267 2633 4565183
SGTC_882 0843-0131 351 µM -0.116824718788286 0.456873594875761 no 1856 0.45349947755731 2594 5425421
SGTC_2075 5212009 200 µM -0.117155315998198 0.456751256742375 no 1857 0.453368487833477 2681 780898
SGTC_1659 st012954 42.1 µM -0.117803081046982 0.456511561934963 no 1858 0.453111844113351 2725 24207262
SGTC_1856 st057054 55.7 µM -0.119149907120694 0.456013241839004 no 1859 0.452578296080953 2822 1266018
SGTC_1606 st000094 49.2 µM -0.121249146014929 0.455236670340069 no 1860 0.451746849169863 2612 1242210
SGTC_2725 haloperidol 53.21 µM -0.123525792277415 0.45439466392477 no 1861 0.450845375703617 2625 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2993 9054257 71.4286 µM -0.123547197574177 0.454386748247493 no 1862 0.450836901139353 2622 6470217 YGL055W OLE1
SGTC_1337 1486-1011 40.3 µM -0.12508248561699 0.453819046272138 no 1863 0.450229124422415 2633 X1337
SGTC_502 l-744,832 89.3 µM -0.128130882823197 0.452692124133322 no 1864 0.449022698258187 2695 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2356 9061756 188.97 µM -0.128517682129506 0.452549160397756 no 1865 0.448869652971334 2672 20104043
SGTC_710 3448-4187 58 µM -0.130031845605705 0.451989574304286 no 1866 0.448270615714183 2652 3946412
SGTC_2967 9089538 49.85 µM -0.13167314868771 0.451383109250925 no 1867 0.44762141240303 2813 728216
SGTC_2027 5150920 200 µM -0.132131440294277 0.451213789709112 no 1868 0.447440164082505 2724 786715
SGTC_2430 5571206 200 µM -0.132618991044366 0.45103366988486 no 1869 0.447247356203805 2717 1731771
SGTC_2398 5228213 48.84 µM -0.133166823713184 0.450831291653956 no 1870 0.44703072398238 2697 80771 YMR134W ERG29
SGTC_1694 st024011 44.9 µM -0.134235747879624 0.450436450660477 no 1871 0.446608079493922 2665 2787533
SGTC_2815 7968870 71.43 µM -0.134731522613069 0.450253337188171 no 1872 0.44641207448987 2662 2977326 YHR190W ERG9
SGTC_2787 5284540 71.43 µM -0.134816623631293 0.450221906349768 no 1873 0.446378431038009 2722 736958
SGTC_2465 5809242 33.21 µM -0.135779447496559 0.449866322983783 no 1874 0.445997819548375 2638 2731748
SGTC_1691 st019933 84.6 µM -0.137095261974762 0.449380440738483 no 1875 0.445477748752588 2632 6176082
SGTC_992 3909-8734 162 µM -0.13761887488543 0.449187110676121 no 1876 0.44527081873337 2691 4288319
SGTC_1509 1326-1131 80 µM -0.137652717413962 0.449174615642169 no 1877 0.445257444795036 2633 768313
SGTC_1028 k015-0029 4.8 µM -0.138913892615259 0.448709011922845 no 1878 0.444759096345477 2641 4588309
SGTC_551 k048-0028 34.9 µM -0.138925220744192 0.448704830095847 no 1879 0.444754620474055 2787 6836383
SGTC_1468 k284-1086 134 µM -0.139044171770369 0.448660919162584 no 1880 0.444707622008332 2671 15996457
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.140557651312665 0.44810227121797 no 1881 0.444109702683025 2755 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_3047 9092122 49.47 µM -0.14127313003785 0.447838213071477 no 1882 0.443827087912172 2699 17173831
SGTC_1084 voriconazole 435 nM -0.141613534974383 0.447712589635308 no 1883 0.443692637660759 2668 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2918 7977171 22.06 µM -0.141629887843784 0.447706554885168 no 1884 0.443686178906288 2624 2236483
SGTC_976 1348-1067 47.6 µM -0.142707192261809 0.447309020624004 no 1885 0.44326071812902 2662 5310671 YGL099W LSG1
SGTC_2299 7976368 114.88 µM -0.144329516963364 0.446710469352325 no 1886 0.442620135576346 2767 2979718
SGTC_2813 7971799 71.43 µM -0.14489195252569 0.446502988898268 no 1887 0.442398090170179 2781 2234054
SGTC_804 1595-0054 20.9 µM -0.145035325581151 0.446450101434383 no 1888 0.44234149043817 2671 761523 Stimulates phospholipase C.
SGTC_686 1319-0111 510 µM -0.146672715274227 0.445846168783406 no 1889 0.441695177854723 2788 4562600
SGTC_2888 9058547 12.99 µM -0.146855864035531 0.445778624222261 no 1890 0.441622894757656 2690 16476514
SGTC_2000 st075254 36.4 µM -0.147506423557765 0.445538713099678 no 1891 0.441366154962691 2678 17234175
SGTC_396 dithiazanine 1.25 µM -0.147734779489108 0.445454505501844 no 1892 0.441276041366194 2693 10578 An antihelmenthic.
SGTC_1263 0774-1208 64.8 µM -0.149101670300723 0.444950508025033 no 1893 0.440736703957618 2747 906585
SGTC_763 3453-1109 128 µM -0.149353064595566 0.444857824043842 no 1894 0.440637522640309 2656 1560353
SGTC_2767 sibutramine 71.45 µM -0.149488653575504 0.44480783638618 no 1895 0.440584030952553 2776 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_361 000s-0510 1.45 µM -0.1496256708044 0.444757323066883 no 1896 0.440529976902659 2751 660
SGTC_67 0335-0847 266 µM -0.151354724887536 0.444119960437041 no 1897 0.439847951120809 3059 4552207 YOR254C SEC63
SGTC_676 falcarinol 140 µM -0.152196131937031 0.443809853759146 no 1898 0.439516122346098 2746 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1881 5652484 16 µM -0.153173083066266 0.443449834501301 no 1899 0.439130891882166 2755 2255129
SGTC_1507 4075-3230 155 µM -0.153345412083281 0.443386333840732 no 1900 0.439062945234349 2628 659771
SGTC_1826 st055655 41.6 µM -0.153379555691563 0.443373752605202 no 1901 0.439049483154358 2724 676168
SGTC_1607 st000305 50.6 µM -0.153823566124009 0.44321014885973 no 1902 0.438874425950855 2834 5457690
SGTC_1974 st069448 26.9 µM -0.154686057690145 0.442892375796608 no 1903 0.438534411019123 2788 6323587 YNR016C ACC1
SGTC_1756 st041558 35.5 µM -0.154695100408338 0.442889044326642 no 1904 0.438530846401843 2799 3955792
SGTC_934 2950-0684 338 µM -0.155999636701741 0.442408476453755 no 1905 0.438016653792801 2900 1121253
SGTC_2716 st080858 38.6235 µM -0.156199508414373 0.442334854752419 no 1906 0.437937882104184 2788 5296050
SGTC_2316 5844804 197.44 µM -0.157002578635032 0.442039068132927 no 1907 0.437621407925227 2795 776813
SGTC_13 0199-0087 65 µM -0.158578674013062 0.44145865517497 no 1908 0.437000415917011 2683 4589825
SGTC_1176 0848-0131 83.3 µM -0.160107042648304 0.440895938096036 no 1909 0.43639837675718 2786 6769040
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.16078197809511 0.440647477252989 no 1910 0.436132559975764 2739 688788
SGTC_2296 7971656 126.45 µM -0.161688024871072 0.440313975224085 no 1911 0.435775767609871 2762 666570
SGTC_1498 4478-3555 97.6 µM -0.162443012840856 0.440036107970533 no 1912 0.435478500634343 2707 3437919
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.165647961955095 0.43885688259834 no 1913 0.434217000238847 2714 641818 YHR062C RPP1
SGTC_2651 TUB2.036 5 µM -0.166385489526126 0.438585593939683 no 1914 0.433926796234159 2780 15992207 YFL037W TUB2
SGTC_3009 9080819 71.4286 µM -0.167802432450385 0.438064473417241 no 1915 0.433369354408567 2772 17027216
SGTC_849 0386-0493 241 µM -0.167912785741838 0.438023892393387 no 1916 0.433325945688788 2707 726119
SGTC_1880 MG-132 525 µM -0.168847287928594 0.43768026723274 no 1917 0.432958380943806 2782 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1560 lithocholic acid 53.1 µM -0.169315279959215 0.437508199846734 no 1918 0.432774328914644 2696 9903 A bile acid which acts as a detergent.
SGTC_617 3770-0098 35 µM -0.169404327440592 0.437475460952641 no 1919 0.432739309947923 2715 5962639
SGTC_1957 st077035 62.4 µM -0.169534849937684 0.437427474268995 no 1920 0.432687981399402 2714 705593
SGTC_2770 toltrazuril 17.5 µM -0.172065119458337 0.436497401688338 no 1921 0.431693167189129 2694 68591 Kills coccidiodes.
SGTC_598 3937-0236 20.2 µM -0.172974044271692 0.436163385915135 no 1922 0.431335914870319 2779 1379313
SGTC_2012 4023501 200 µM -0.175722942269838 0.435153486500728 no 1923 0.430255805217489 2784 3477460
SGTC_2760 etidronate 98.04 µM -0.176322271582769 0.434933358795486 no 1924 0.430020382971937 2758 3305 A chelator and antioxidant.
SGTC_1209 2323-2347 50.3 µM -0.176726766166859 0.434784803345208 no 1925 0.429861507713755 2706 5412760
SGTC_1519 esterone 74 µM -0.176794242042553 0.434760022922171 no 1926 0.429835005998286 2704 698 A steroid.
SGTC_2033 5192550 145 µM -0.177995951099247 0.43431873993008 no 1927 0.429363077760786 2753 182073
SGTC_454 lyso-paf C-16 6.67 µM -0.178339278986329 0.434192680527337 no 1928 0.429228266525601 2788 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.178955434713685 0.433966463951919 no 1929 0.428986347334781 2795 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2763 lisinopril 49.32 µM -0.179453912285422 0.433783467777184 no 1930 0.428790651244483 2718 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1240 0356-0016 42.1 µM -0.179619947347618 0.433722517769995 no 1931 0.428725471829681 2798 4305613
SGTC_35 0133-0054 64.071 µM -0.180291037305245 0.433476182636868 no 1932 0.428462045787952 2754 99677
SGTC_1211 1056-0033 32.3 µM -0.180341683363506 0.433457593175902 no 1933 0.428442166748627 2740 6741922
SGTC_2917 7979103 53.79 µM -0.181307445162583 0.433103141853475 no 1934 0.428063131241637 2885 2980565
SGTC_1555 citronellol 128 µM -0.181940192958305 0.432870941601718 no 1935 0.427814830728129 2748 8842 A terpine precursor.
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.182092184642483 0.432815168472107 no 1936 0.427755190976262 2668 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_920 mycophenolic acid 780.421 nM -0.182202141567448 0.432774820771133 no 1937 0.427712046199161 2772 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_936 3005-4620 401 µM -0.182652359716302 0.432609624600085 no 1938 0.427535399118372 2928 777207
SGTC_2122 5258151 111.688 µM -0.183584326639702 0.432267700349979 no 1939 0.427169779831522 2761 2173356
SGTC_24 0417-1663 219 µM -0.184162171490072 0.432055723469532 no 1940 0.4269431173206 2804 4329390
SGTC_3287 9117173 37.0625 µM -0.184230325570031 0.43203072308267 no 1941 0.426916385133163 2749 2789709
SGTC_2610 ononetin 44.17 µM -0.184770172372431 0.43183270525374 no 1942 0.426704651998242 2809 259632
SGTC_910 3454-3003 490 µM -0.185774706250977 0.431464284085643 no 1943 0.426310720355656 2776 820824
SGTC_2204 7233102 200 µM -0.186255824313412 0.431287851122094 no 1944 0.42612207415434 2753 2172480
SGTC_903 1134-0042 114 µM -0.188698665968734 0.430392237936113 no 1945 0.425164498604035 2749 701009
SGTC_2757 clomiphene 4.22 µM -0.189061298534995 0.430259317228788 no 1946 0.425022386850453 2921 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2516 gossypol 71.55 µM -0.189192658358658 0.430211170053006 no 1947 0.424970910768977 2884 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2818 7996756 12.99 µM -0.190350095990937 0.429786980604512 no 1948 0.424517400130313 2721 2241621
SGTC_828 2074-0507 139 µM -0.190501232996571 0.429731596357862 no 1949 0.424458188543463 2882 X828
SGTC_3090 9117696 49.47 µM -0.190655019189989 0.429675242734176 no 1950 0.424397940822934 2834 7923821
SGTC_2583 asiatic acid 100 µM -0.192129044204136 0.429135171835106 no 1951 0.423820562359375 2899 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1722 st034304 3.6505 µM -0.19241163222127 0.429031648980456 no 1952 0.423709890722668 2778 4036148 YLR033W RSC58
SGTC_1558 st069300 45.6 µM -0.192784104213047 0.428895205628901 no 1953 0.423564026481087 2790 24208000
SGTC_2845 9003024 42.97 µM -0.19360462894795 0.428594662302086 no 1954 0.423242736698831 2979 2990173
SGTC_279 1273-0055 2.93 µM -0.194175598141576 0.428385551062735 no 1955 0.423019194540925 2823 2847562
SGTC_435 c-PAF 6.7 µM -0.194713872317826 0.428188432427618 no 1956 0.422808475617431 2910 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2789 5281112 71.43 µM -0.194994646778309 0.428085618554847 no 1957 0.422698569218172 2813 765948
SGTC_1488 4013-0813 75.9 µM -0.196835340631146 0.42741171528272 no 1958 0.421978197133986 2761 2910057
SGTC_887 0885-0007 9.62 µM -0.198074050414465 0.426958325708045 no 1959 0.421493563676938 2892 5719458
SGTC_2436 5633522 8.09 µM -0.199328842433652 0.426499148115799 no 1960 0.421002759419421 2867 5724242
SGTC_1194 1488-0194 225 µM -0.199999837527006 0.426253645539267 no 1961 0.420740354094775 2737 1391452
SGTC_871 0574-0004 149 µM -0.200508769959925 0.42606745723225 no 1962 0.420541349915411 2769 9551173
SGTC_1295 1013-0063 9.78 µM -0.200532991731564 0.426058596327638 no 1963 0.42053187915654 2845 6826038
SGTC_118 0083-0097 135.343 µM -0.202278443679671 0.425420166716088 no 1964 0.419849525548326 2801 5207356
SGTC_1352 1496-0991 99 µM -0.203541762371294 0.424958207641366 no 1965 0.419355803567122 2752 3000039
SGTC_2375 9072683 200 µM -0.203867143554779 0.424839241822205 no 1966 0.419228660739968 2856 16798029
SGTC_3148 9097893 49.47 µM -0.204667278878454 0.424546725600739 no 1967 0.418916043438826 2801 17174100
SGTC_927 2425-1185 123 µM -0.204840009721081 0.424483583513311 no 1968 0.418848563253898 2741 730375
SGTC_1933 st074711 15.9 µM -0.204966447715678 0.424437365092739 no 1969 0.418799169655619 2716 17250958
SGTC_1787 fluconazole 80 µM -0.20517264215833 0.424361994555105 no 1970 0.418718621571372 2805 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_957 1187-1561 14.1 µM -0.206177750665147 0.423994635514742 no 1971 0.418326033434357 2750 1538454
SGTC_1346 1488-2224 62.4 µM -0.208138062618986 0.423278347596832 no 1972 0.417560584109552 2801 3722427
SGTC_2310 7668677 200 µM -0.208372942403297 0.423192540690444 no 1973 0.417468890735985 2983 2197143
SGTC_1842 st055362 61.2 µM -0.208819632988234 0.423029364555625 no 1974 0.417294522143825 2795 676032
SGTC_2345 9052315 157.45 µM -0.209627317430311 0.422734350852482 no 1975 0.416979278551239 2867 6469265
SGTC_418 lividomycin a 100 µM -0.209817738524557 0.422664804212615 no 1976 0.416904963938739 2796 72394 An antibiotic.
SGTC_358 0075-0058 9.45 µM -0.210354717105184 0.422468698930498 no 1977 0.416695416206897 2688 1069125
SGTC_851 0394-0702 453 µM -0.210409390212113 0.422448733317172 no 1978 0.41667408218428 2883 762646
SGTC_1315 1237-0019 3.69 µM -0.210616820113685 0.422372985543794 no 1979 0.416593143082648 2875 825140
SGTC_958 1222-0007 33 µM -0.211006298805704 0.42223076624837 no 1980 0.416441178138782 2946 7312461
SGTC_2702 st077768 96.8 µM -0.214347927026426 0.421010979388425 no 1981 0.415137873035995 2869 6484119
SGTC_265 mycophenolic acid 32.932 µM -0.214787282985601 0.420850658414071 no 1982 0.414966584110062 3027 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_3142 9086498 49.47 µM -0.215491101129974 0.420593862562405 no 1983 0.41469222468522 2927 25236367
SGTC_2486 5283202 22.39 µM -0.215494215054999 0.42059272648734 no 1984 0.414691010920437 2851 1377751
SGTC_2435 5706476 10.6 µM -0.216201393368551 0.420334738822228 no 1985 0.414415383740493 2931 5725375
SGTC_2247 cerulenin 830 nM -0.216288530274513 0.420302952533828 no 1986 0.414381424498579 3012 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_216 k038-0035 28.382 µM -0.216670389512301 0.420163661915531 no 1987 0.41423261278554 2817 4444231 YPR107C YTH1
SGTC_2337 9009472 200 µM -0.216708191908317 0.420149873296571 no 1988 0.414217881745578 2970 5742383
SGTC_1042 0350-0096 82 µM -0.217330803597691 0.4199227865828 no 1989 0.413975276467365 2757 3122515
SGTC_975 1335-0046 28.5 µM -0.217542287292004 0.419845657669509 no 1990 0.413892877736107 2833 16486740
SGTC_284 0988-0104 32.6 µM -0.219465894793677 0.419144252358596 no 1991 0.413143572136633 2886 4666532
SGTC_3007 9078383 71.4286 µM -0.219624858278994 0.41908630093883 no 1992 0.413081664972923 2838 6496995
SGTC_1458 k015-0034 6.33 µM -0.219635713790689 0.419082343538568 no 1993 0.413077437452314 2853 3598957
SGTC_1564 D-Arginine 115 µM -0.22016556847543 0.418889193826848 no 1994 0.412871105539605 2829 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_940 3232-1287 54.8 µM -0.220507074956558 0.41876471367751 no 1995 0.412738131479542 2786 1585493 YIL048W NEO1
SGTC_1013 4112-3890 241 µM -0.221503033465322 0.418401730268049 no 1996 0.412350387448022 2783 705171
SGTC_3001 9076041 71.4286 µM -0.222331400428209 0.418099879572406 no 1997 0.412027954867376 2786 16004211
SGTC_2871 9038510 12.99 µM -0.223766363815482 0.417577103944318 no 1998 0.411469552049859 2918 4945164
SGTC_918 glabranin 770.725 nM -0.224305547583846 0.417380709952545 no 1999 0.411259779917721 2850 124049 Also referred to as licorice root.
SGTC_2005 4024620 188 µM -0.225168909228056 0.417066279332197 no 2000 0.410923937624488 2795 236743
SGTC_2831 7999036 19.48 µM -0.225259609570071 0.417033249940604 no 2001 0.41088865954254 3092 2988270
SGTC_1116 jasmonic acid 1.58368 µM -0.227349854283599 0.416272230165993 no 2002 0.410075854887362 2966 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1465 k213-0056 144 µM -0.230233079475823 0.415223016197381 no 2003 0.408955329247093 2801 24048857 YMR208W ERG12
SGTC_64 000l-0018 272.079 µM -0.230840914714747 0.415001900074814 no 2004 0.408719197085429 2775 6811119
SGTC_1524 corynanthine 62.1 µM -0.231235795515339 0.414858266175884 no 2005 0.408565811326477 3002 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_153 4077-0274 519.67 µM -0.23126187033388 0.414848782124626 no 2006 0.408555683431486 3100 3121976
SGTC_2321 7390090 138.78 µM -0.231389445089662 0.41480238077138 no 2007 0.408506132146239 2898 649046
SGTC_792 4534-1957 155 µM -0.231964899066008 0.414593092051273 no 2008 0.408282638373528 2864 1717904
SGTC_3212 9128307 49.47 µM -0.232963910746845 0.414229815866409 no 2009 0.407894714914819 2804 27243542
SGTC_384 k007-0144 5.16 µM -0.23300438953608 0.414215097883211 no 2010 0.40787899860879 2881 6824886
SGTC_2056 5235370 200 µM -0.233104562939882 0.414178675610352 no 2011 0.407840105892381 2848 5511916
SGTC_210 3551-0445 56.827 µM -0.234124271750424 0.41380795944314 no 2012 0.407444251691645 2938 2865180 YOR207C RET1
SGTC_863 0466-0191 129 µM -0.234415969909049 0.413701926396104 no 2013 0.407331030904269 2931 765160 YPR165W RHO1
SGTC_2921 7974240 10.71 µM -0.234523153754832 0.413662966366926 no 2014 0.407289430119838 2951 2979074 YDR527W RBA50
SGTC_1505 k297-0037 20.6 µM -0.23509871270729 0.413453772206587 no 2015 0.407066058905355 2833 4089396
SGTC_1325 1431-0015 227 µM -0.23532068757115 0.413373099203341 no 2016 0.406979919772495 2823 1103340
SGTC_2304 7443016 91.4 µM -0.237204422469119 0.412688635203095 no 2017 0.406249102789861 2763 939854
SGTC_1927 st060202 13.8 µM -0.237322360951339 0.412645790503547 no 2018 0.406203358011129 2784 688887
SGTC_189 3970-0742 2.116 µM -0.237536855068077 0.412567871734717 no 2019 0.406120165497297 2843 2891807
SGTC_1086 cerivastatin 2.18 µM -0.23839415440462 0.412256477073518 no 2020 0.405787700431608 2814 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_404 fumagillin 50 µM -0.238593619566725 0.41218403376203 no 2021 0.405710356556234 2874 12015870 A methionine aminopeptidase binder.
SGTC_177 1327-0068 8.361 µM -0.239370785753353 0.411901805054357 no 2022 0.405409040598891 2836 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1400 3771-8998 51.5 µM -0.240890692272971 0.411349981243912 no 2023 0.404819918122323 2835 670767
SGTC_2173 5763948 167 µM -0.242445095929156 0.410785814102918 no 2024 0.404217647467685 2805 2867177
SGTC_716 1683-5115 658 µM -0.242944389358587 0.410604635826533 no 2025 0.404024238868388 2803 723597
SGTC_965 1291-5240 308 µM -0.245879269967286 0.409540044440681 no 2026 0.402887845730989 2958 2834598
SGTC_1387 3342-1166 1.8 µM -0.246415234680454 0.409345701676285 no 2027 0.402680407099119 2920 3418228
SGTC_1553 gossypol 38.6 µM -0.24743983143253 0.408974241186481 no 2028 0.402283925661661 2815 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1665 st014639 11.4 µM -0.247681112465289 0.408886778289266 no 2029 0.402190573340387 2872 981133 YIL048W NEO1
SGTC_2479 5617353 43.85 µM -0.250058517944109 0.408025226599556 no 2030 0.401271047459351 3002 2731746
SGTC_1047 2043-3044 82 µM -0.250199210259168 0.407974254781952 no 2031 0.401216647979896 2857 669592
SGTC_1706 st031321 9.9705 µM -0.250233814554846 0.407961718132194 no 2032 0.401203268326602 2948 6103185
SGTC_478 N-arachidonylglycine 10 µM -0.250855049084442 0.407736669639589 no 2033 0.400963089472648 2861 5283389
SGTC_48 0382-0018 55 µM -0.251668166809829 0.407442155525868 no 2034 0.400648782180141 3119 762596
SGTC_2125 5246583 200 µM -0.253529811340876 0.406768058540371 no 2035 0.399929413683236 2957 835267
SGTC_190 3970-0790 3.722 µM -0.254007329592186 0.406595194755967 no 2036 0.399744947788123 2914 2832352
SGTC_425 3825-7017 13.1 µM -0.254546344109293 0.406400090910965 no 2037 0.399536752691516 3107 3397440
SGTC_2920 7982904 15.77 µM -0.255922920913367 0.405901925234495 no 2038 0.399005177768096 2956 6456808
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.256685193279679 0.405626134017816 no 2039 0.398710901360586 3003 61125 An anti-inflammatory.
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.256851808065867 0.405565858786681 no 2040 0.398646587130616 2799 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_3233 9132340 49.47 µM -0.259762923032841 0.40451308475898 no 2041 0.39752332625897 2885 17682950
SGTC_2782 7736369 71.43 µM -0.260163180023302 0.404368389901023 no 2042 0.397368952312411 2910 2950836 YOL077C BRX1
SGTC_2332 7982454 138.89 µM -0.26118656523725 0.403998490664187 no 2043 0.396974319012203 2933 2981748
SGTC_86 0417-1630 471.922 µM -0.26276464605907 0.403428266834417 no 2044 0.396365993281891 2909 3634867
SGTC_2474 5321570 43.32 µM -0.262986238675474 0.403348212949786 no 2045 0.396280592918954 2991 2841384
SGTC_1397 3532-0190 20.1 µM -0.265461676873435 0.402454197289037 no 2046 0.395326914251275 2823 5322280
SGTC_218 alverine citrate 93.75 µM -0.266124959247882 0.402214736300048 no 2047 0.395071486598679 3005 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_258 haloperidol 50.781 µM -0.266491564823806 0.402082398554935 no 2048 0.394930327450903 2913 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1822 st052468 42 µM -0.266657236527247 0.402022597854974 no 2049 0.394866541137095 2926 2873678
SGTC_3054 9094397 49.47 µM -0.267158903804005 0.401841530506651 no 2050 0.394673408227482 2913 2598354
SGTC_1294 1000-1494 117 µM -0.267179800650004 0.40183398864074 no 2051 0.394665363877545 2889 712797 YDL207W GLE1
SGTC_3347 9188721 44.724 µM -0.267692490560164 0.401648965545386 no 2052 0.394468015297016 2948 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1684 st024538 14.6195 µM -0.267774373610383 0.401619417062087 no 2053 0.394436498744529 2876 6732859
SGTC_2471 5466956 24.79 µM -0.268609241002318 0.401318177256759 no 2054 0.394115200141811 2890 724419
SGTC_515 4092-1064 102 µM -0.268774324584551 0.401258618153805 no 2055 0.394051676272285 3124 717353
SGTC_2339 9000433 200 µM -0.269708390762451 0.400921667608851 no 2056 0.393692302401732 2938 2988954
SGTC_1027 k015-0025 8.67 µM -0.272342714825042 0.399971771967149 no 2057 0.392679257651639 2869 3598955
SGTC_879 0831-1030 162 µM -0.272528036327812 0.399904970167683 no 2058 0.392608018459518 2904 1549252
SGTC_166 k072-0058 166.424 µM -0.272591557120994 0.399882073858719 no 2059 0.392583601343825 2968 5846229
SGTC_3258 9138477 49.47 µM -0.272851321691931 0.399788444324328 no 2060 0.392483753377051 2918 4970355
SGTC_2653 dihydrofissinolide 100 µM -0.273011041165294 0.399730877902049 no 2061 0.392422364127207 2937 6857746
SGTC_2188 6126565 140.678 µM -0.274787089470019 0.399090898035569 no 2062 0.391739908767415 3003 874518
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.275403107172049 0.398868985939793 no 2063 0.391503278588519 2952 6857784
SGTC_2180 6301957 200 µM -0.27694614533273 0.398313270813491 no 2064 0.390910729483879 3016 845462
SGTC_2485 5633444 17.78 µM -0.277729413481219 0.398031260716794 no 2065 0.390610039908494 2994 5724239
SGTC_3177 9107506 49.47 µM -0.278654255969188 0.397698346373932 no 2066 0.390255085439393 3009 8897194
SGTC_1965 Pectolinarigenin 58.4 µM -0.281625836043475 0.396629175884183 no 2067 0.389115213721462 2904 5320438 An anti-inflammatory.
SGTC_1179 1021-1431 9.29 µM -0.284906521860982 0.395449691897746 no 2068 0.387857879626944 2977 2840958
SGTC_2080 5212524 12.4 µM -0.290659919561976 0.393383526405902 no 2069 0.385655714124476 2983 260183
SGTC_1642 st009582 77.7 µM -0.290786678253685 0.393338038261364 no 2070 0.385607237260065 3060 6739311
SGTC_1901 st060216 58.6 µM -0.291801109191133 0.392974055912737 no 2071 0.385219348560071 2901 688792
SGTC_798 1287-0182 476 µM -0.292357844393377 0.392774336577234 no 2072 0.385006518081928 3122 1649755
SGTC_332 4112-0506 40.9 µM -0.292766389502513 0.39262779588484 no 2073 0.384850360209419 2917 2790355
SGTC_3302 9125395 16.351 µM -0.292822216563646 0.39260777250604 no 2074 0.384829022926101 2966 17599668
SGTC_1360 1598-0022 39.8 µM -0.295311776571033 0.391715136781453 no 2075 0.383877860539368 3051 761525
SGTC_2034 5197015 53.07 µM -0.295397597737378 0.391684375597759 no 2076 0.383845084100143 3078 780676
SGTC_377 3970-0964 33.1 µM -0.296611849784153 0.3912492196089 no 2077 0.383381431493446 2917 16481235
SGTC_2706 st078239 82.5 µM -0.296855968981507 0.391161750123876 no 2078 0.383288236632715 2934 15434492
SGTC_354 2783-3500 4.88 µM -0.298613047237593 0.390532340285607 no 2079 0.382617654588682 2958 6740761
SGTC_2721 ifenprodil 61.44 µM -0.299426493748366 0.390241049449468 no 2080 0.382307324912905 3078 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_744 1594-0068 283 µM -0.299805776199575 0.390105251486812 no 2081 0.382162654559635 2962 668392
SGTC_3126 9127922 49.47 µM -0.300271498560301 0.389938522996911 no 2082 0.381985035786289 3168 45595682
SGTC_1378 2093-0007 380 nM -0.300441399921192 0.389877703390801 no 2083 0.381920244410424 3050 3618014
SGTC_1459 k035-0031 35.7 µM -0.300515028065812 0.389851347554224 no 2084 0.381892167564719 2905 3877128 YMR208W ERG12
SGTC_674 0498-0004 451 µM -0.300944728386658 0.389697542682495 no 2085 0.381728321023183 2998 4231473
SGTC_831 k061-1017 217 µM -0.30158445497034 0.389468594022887 no 2086 0.381484429842192 3006 1240153
SGTC_457 grayanotoxin iii 135 µM -0.301949719288619 0.389337888536987 no 2087 0.381345196530768 2979 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_820 1582-0060 59.9 µM -0.302067564693099 0.389295721632913 no 2088 0.381300278895275 2982 3848840
SGTC_1289 0976-0073 69.1 µM -0.303282316241612 0.388861140843632 no 2089 0.380837360771849 3047 3391136
SGTC_1115 galangin 695.678 nM -0.304022948211285 0.388596245857889 no 2090 0.380555204006965 3091 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1004 4084-0029 199 µM -0.30582110618833 0.387953331091636 no 2091 0.379870428746797 3108 716894 YLR208W SEC13
SGTC_889 0919-1524 82.7 µM -0.305822867662566 0.387952701443036 no 2092 0.379869758125699 3005 3905452
SGTC_2052 5265182 7.135 µM -0.306355674336438 0.387762260311081 no 2093 0.379666926788928 3107 1239884
SGTC_1661 st013063 9.66 µM -0.306885102921793 0.387573053348691 no 2094 0.379465414229533 2956 721395
SGTC_448 monastrol 171 µM -0.307143409726942 0.387480749460107 no 2095 0.379367108665006 3001 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2800 7887935 81.82 µM -0.307821897041911 0.387238327703225 no 2096 0.379108929329642 3121 2961002
SGTC_751 0833-0568 350 µM -0.308853611191147 0.386869783207564 no 2097 0.378716442782494 3036 6954252
SGTC_1778 st046819 58.9 µM -0.309057068374648 0.386797117135051 no 2098 0.378639057984999 2961 671715
SGTC_1583 clindamycin 39.6 µM -0.310768642658266 0.386185974455478 no 2099 0.377988254827458 2950 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_662 k832-1615 104 µM -0.313758111586153 0.385119218669093 no 2100 0.376852380510244 3055 5878478
SGTC_1443 4112-3303 14 µM -0.31421841910208 0.384955040492751 no 2101 0.376677577108735 2962 704433
SGTC_1233 0325-0408 14.2 µM -0.315896811183564 0.384356582214537 no 2102 0.376040416198265 3068 12874
SGTC_3160 9100216 49.47 µM -0.31611598330223 0.3842784531044 no 2103 0.375957237707116 2931 17191039
SGTC_1356 1502-0781 85.8 µM -0.316509648238222 0.384138133690752 no 2104 0.375807851537808 2967 567702
SGTC_1510 1123-0200 71.5 µM -0.317515915402015 0.383779525085528 no 2105 0.375426082519084 3153 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2176 5809774 33.9695 µM -0.317556870075107 0.383764931963359 no 2106 0.375410547252433 3084 2870539
SGTC_1815 st051655 58.2 µM -0.318349207769212 0.383482635703159 no 2107 0.375110030933575 3064 5984156
SGTC_2944 9067346 25.62 µM -0.318747000948825 0.38334093215979 no 2108 0.374959185267602 3143 6473075
SGTC_2163 5671233 125 µM -0.319935998048143 0.382917475760444 no 2109 0.374508424218569 3190 701023
SGTC_3224 9130643 49.47 µM -0.320421968866253 0.382744439509631 no 2110 0.374324236997834 3157 17644395
SGTC_209 4077-0173 175.592 µM -0.320480610647071 0.382723560920083 no 2111 0.374302013184695 3038 15993494
SGTC_517 1365-0151 113 µM -0.321411375605761 0.382392220687967 no 2112 0.373949331801051 3138 768657
SGTC_1078 idebenone 36.1 µM -0.322572694266617 0.381978927072399 no 2113 0.37350943797375 3037 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_102 gallobenzophenone 83.616 µM -0.323015945608455 0.381821216866915 no 2114 0.373341583001663 3146 70837
SGTC_2560 caryophyllene 100 µM -0.325709726147283 0.380863184039321 no 2115 0.372321992392329 2953 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_195 4234-0266 16.654 µM -0.328958779347795 0.379708642123038 no 2116 0.371093422444996 3017 2303354
SGTC_3089 9117425 49.47 µM -0.329820068523167 0.379402764691832 no 2117 0.370767961310881 3040 9401657
SGTC_2243 6634756 200 µM -0.330581249186452 0.379132502517716 no 2118 0.37048040579512 3233 885676
SGTC_134 0269-0018 6.916 µM -0.33232532023244 0.378513481601245 no 2119 0.369821811271303 3063 4378915
SGTC_164 4100-3994 89.624 µM -0.332509265103273 0.378448212420539 no 2120 0.369752372391734 3106 4615967
SGTC_1370 2001-0092 44.6 µM -0.334401130380526 0.377777123184917 no 2121 0.369038443268419 3215 790957
SGTC_926 2268-1401 59.4 µM -0.334451462279572 0.377759274299802 no 2122 0.369019455784047 2981 2931578
SGTC_507 nimesulide 162 µM -0.334573726541898 0.377715917579783 no 2123 0.368973333467856 3184 4495 A COX2 inhibitor.
SGTC_1266 0828-0227 32.9 µM -0.334599709350246 0.377706703889212 no 2124 0.368963532095298 3100 3913820
SGTC_2123 5259487 200 µM -0.334856530400288 0.377615637042875 no 2125 0.368866657283372 3115 2173474
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.336073772880153 0.377184104466851 no 2126 0.368407617768639 2914 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1423 4048-0112 5.59 µM -0.338109332084805 0.376462807919463 no 2127 0.367640399135895 3080 X1423
SGTC_2083 5306046 65.942 µM -0.340214309508021 0.375717366599263 no 2128 0.366847571410562 3023 539837
SGTC_2491 paeonol 100 µM -0.340490017917196 0.375619763520745 no 2129 0.366743769384955 2950 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1944 st076371 56.9 µM -0.340815861589497 0.375504422402766 no 2130 0.36662110439461 2983 24208455
SGTC_330 1488-0319 80.1 µM -0.341298556279792 0.375333580107457 no 2131 0.366439417328368 3079 6846614
SGTC_2696 st077691 74.316 µM -0.342135607852823 0.375037376668032 no 2132 0.366124420728708 3172 757133
SGTC_2357 9067248 200 µM -0.343542585417817 0.374539662337741 no 2133 0.365595154706686 3105 9150235
SGTC_2582 agaric acid 100 µM -0.347177934974608 0.373254637007467 no 2134 0.364228823224948 3124 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1887 st057648 70.8 µM -0.347688767879942 0.373074180051975 no 2135 0.364036966468832 3133 688672
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.347770767250986 0.373045215526707 no 2136 0.364006172617192 3121 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1126 isoteolin 1.0172 µM -0.349613449773996 0.372394516834838 no 2137 0.36331440787416 3001 133323
SGTC_2157 5649910 96.377 µM -0.350474581157752 0.372090553870337 no 2138 0.362991281621984 3013 2858091
SGTC_111 0083-0039 52.457 µM -0.351717561066488 0.371651946224494 no 2139 0.362525044610747 2974 759313
SGTC_1760 st045453 10.4495 µM -0.35174316165279 0.371642914349382 no 2140 0.362515444068347 3156 3323419 YIL048W NEO1
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.351758322848085 0.371637565519944 no 2141 0.362509758469858 3028 5106787 A p450 inhibitor.
SGTC_38 0929-0051 58.268 µM -0.352059405567531 0.371531349470026 no 2142 0.36239685574776 3153 1379719
SGTC_262 fenpropimorph 62.5 µM -0.35209199877879 0.371519851813991 no 2143 0.362384634368214 3046 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1402 3909-7673 35.9 µM -0.352395249822762 0.371412881775484 no 2144 0.362270931950053 2976 5328014
SGTC_2508 celastrol 40.54 µM -0.353318715764857 0.371087195743671 no 2145 0.361924758022228 3059 122724 Celastrol is a natural product and antioxidant.
SGTC_3299 9121982 43.1275 µM -0.354525299807432 0.370661799339918 no 2146 0.361472623586069 3046 17594604 YPL160W CDC60
SGTC_37 0566-0070 1.56 µM -0.35547371646371 0.370327534026108 no 2147 0.361117366034008 3105 1626686
SGTC_477 mead ethanolamide 10 µM -0.356035376852481 0.370129625408713 no 2148 0.360907035937785 3048 16061185
SGTC_2206 7254556 146.969 µM -0.356690376051033 0.369898871030231 no 2149 0.360661805528814 3074 4398905
SGTC_2084 5306078 60.6385 µM -0.356807242829646 0.369857704113546 no 2150 0.360618056857101 3045 679340
SGTC_226 1,3-diallylurea 8.28947 mM -0.35896704079941 0.369097173218205 no 2151 0.359809872935813 3112 74537 YKL182W FAS1
SGTC_2389 9091542 195.52 µM -0.359113449938751 0.36904563658722 no 2152 0.359755110113219 3081 3626624 YOL127W RPL25
SGTC_1239 0337-0584 35.4 µM -0.359528587640444 0.368899519179047 no 2153 0.359599847813989 3203 914301 YML130C ERO1
SGTC_3336 9143619 71.43 µM -0.360117835064732 0.368692152324367 no 2154 0.359379507936231 3163 45595730
SGTC_1413 3910-0535 34.4 µM -0.361423258090837 0.368232886519203 no 2155 0.358891531979055 3155 2876951
SGTC_587 k089-0003 57 µM -0.362908583547475 0.36771055751048 no 2156 0.358336587262059 3089 9659696
SGTC_1412 3909-8563 178 µM -0.364132980368103 0.367280170423776 no 2157 0.357879355068743 3159 23767530
SGTC_850 0388-0143 75.9 µM -0.36471181715785 0.367076761801757 no 2158 0.357663268271259 3047 67273
SGTC_757 1066-0008 322 µM -0.365278850871523 0.366877537061708 no 2159 0.357451631932193 3177 6842497
SGTC_1117 retinoic acid 1.10837 µM -0.366695549894533 0.366379943021191 no 2160 0.356923063177059 3201 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2829 7992743 58.44 µM -0.367068870521271 0.366248857164048 no 2161 0.35678382334968 3190 16462845
SGTC_501 nsc-95397 161 µM -0.367227452877069 0.366193178104898 no 2162 0.356724681627589 3217 262093
SGTC_2938 9059746 27.26 µM -0.367489276279036 0.366101256763211 no 2163 0.356627044715602 3152 6471769
SGTC_1389 3405-0187 19 µM -0.368436511442073 0.365768764283689 no 2164 0.356273888507323 3078 799890
SGTC_1924 st058459 75.1 µM -0.368832360133067 0.365629845838635 no 2165 0.356126341350447 3096 688683
SGTC_1185 1319-0113 81.3 µM -0.36976223755076 0.365303585633294 no 2166 0.355779827095798 3153 4672763
SGTC_2217 6934799 96.0675 µM -0.370409267565765 0.365076623789822 no 2167 0.355538784803674 3142 675606
SGTC_1186 1319-0216 26 µM -0.37078797387235 0.364943805068841 no 2168 0.355397729677349 3204 4565136
SGTC_845 0330-0138 4.51 µM -0.371348850748003 0.364747125815486 no 2169 0.355188858647249 3120 9039800
SGTC_1636 st007707 68.9 µM -0.372123547389865 0.364475526232633 no 2170 0.354900432499185 3265 403051
SGTC_101 0490-5701 117.494 µM -0.372798555737173 0.364238931650449 no 2171 0.354649188923368 3140 4661669
SGTC_2244 6635614 200 µM -0.372889326518685 0.364207119876203 no 2172 0.354615408122867 2954 836499
SGTC_152 4469-0003 551.229 µM -0.373425386316144 0.364019269989144 no 2173 0.354415934109819 3128 697280
SGTC_1745 st081495 74 µM -0.37679912732547 0.362837771153089 no 2174 0.353161444659749 3104 13842402 YBL026W LSM2
SGTC_2309 7664088 163.95 µM -0.377167841935195 0.362708724564011 no 2175 0.353024438468348 3247 704922
SGTC_2724 maprotiline 69.64 µM -0.380742091834548 0.361458581444878 no 2176 0.351697316169193 3207 4011 A tricyclic antidepressant.
SGTC_1460 k062-0059 9.15 µM -0.381474006641276 0.361202766003894 no 2177 0.351425777678982 2973 1373085
SGTC_492 tmb-8 126 µM -0.382717289711206 0.360768361807218 no 2178 0.350964696709466 3114 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_383 2324-0395 7.37 µM -0.383254776639819 0.36058061896689 no 2179 0.350765433473069 3198 3146421
SGTC_3018 9082602 49.47 µM -0.383603011734874 0.360458999253665 no 2180 0.350636353724898 3153 17332089
SGTC_2189 6047310 154.431 µM -0.385664007512066 0.359739494097423 no 2181 0.349872761141134 3061 711535
SGTC_1934 st074720 32.6 µM -0.387860422994457 0.358973260017587 no 2182 0.349059663847589 3046 17250992
SGTC_2181 6316240 54.2555 µM -0.388184479143594 0.358860258815165 no 2183 0.348939759112601 3174 12779990
SGTC_1316 1272-0050 65.9 µM -0.391482247705992 0.357711002141434 no 2184 0.347720404023558 3093 7340392
SGTC_3100 9120536 49.47 µM -0.391533857800915 0.357693026484637 no 2185 0.347701333583783 3155 16421196
SGTC_717 1532-0246 73.2 µM -0.392383606208973 0.357397106814052 no 2186 0.347387398591765 3156 9561992
SGTC_2442 5158906 48.48 µM -0.395538986493033 0.356299016438228 no 2187 0.346222577638147 3221 1893835
SGTC_1806 st050005 60.3 µM -0.396281282525005 0.356040865810925 no 2188 0.345948766892436 3110 5194765
SGTC_2301 7769476 200 µM -0.396575653687507 0.355938509689842 no 2189 0.345840204491968 3155 977820
SGTC_3236 9132701 49.47 µM -0.397326626229622 0.355677435246297 no 2190 0.345563307537187 3172 24282524
SGTC_2995 9067767 71.4286 µM -0.398732636288593 0.355188820096449 no 2191 0.345045108800386 3157 11673567
SGTC_2172 5754775 163.918 µM -0.399163934280298 0.355038983531526 no 2192 0.344886207884033 3100 2263357
SGTC_3033 9090887 49.47 µM -0.403500770227843 0.35353357943107 no 2193 0.343289934115078 3123 19325384
SGTC_1018 4259-0013 28.1 µM -0.404299018554672 0.353256739817496 no 2194 0.342996423555196 3229 6801262
SGTC_848 0368-0089 85.6 µM -0.404956152591946 0.353028898145279 no 2195 0.342754870842324 3224 762535
SGTC_1793 st048256 72.231 µM -0.406439375805593 0.352514828398393 no 2196 0.342209896400392 3108 672022
SGTC_1434 4073-0095 163 µM -0.409826084665092 0.35134204089821 no 2197 0.340966765001961 3228 24133745
SGTC_737 1950-0117 57.9 µM -0.411719126106219 0.350687112611011 no 2198 0.340272652316194 3239 5393513
SGTC_2099 5377090 177.372 µM -0.412602590747486 0.350381615398789 no 2199 0.339948901406477 3220 2243829
SGTC_1937 st074714 47.2 µM -0.413059124344025 0.350223786501287 no 2200 0.339781648162571 3103 17250970
SGTC_2347 9049783 174.81 µM -0.413461847019533 0.35008458212487 no 2201 0.339634134983469 3264 6467988 YPL169C MEX67
SGTC_560 2332-1943 155 µM -0.414411005166614 0.349756577579502 no 2202 0.339286565296124 3162 21177716
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.415122831975727 0.349510662164767 no 2203 0.339025993016639 3255 5282362
SGTC_1997 st073024 93.8 µM -0.415155173674426 0.349499490549444 no 2204 0.33901415579847 3250 686268
SGTC_1151 3909-8316 15.3 µM -0.416833545647767 0.348919918850364 no 2205 0.338400081913236 3253 800431
SGTC_3310 9130229 44.1445 µM -0.416842241428941 0.348916916958676 no 2206 0.338396901463741 3253 7761258
SGTC_3197 9113331 49.47 µM -0.417182634184166 0.348799416582546 no 2207 0.338272413144579 3327 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2646 retinol 96.75 µM -0.417536518094296 0.348677274560066 no 2208 0.338143009586756 3225 445354 A vitamin A analog and teratogen.
SGTC_1634 st006576 41 µM -0.417946185810824 0.348535898503043 no 2209 0.337993231627457 3307 3915356
SGTC_2601 securinine 100 µM -0.418549011296792 0.348327902082965 no 2210 0.33777288019929 3121 442872 A GABA receptor antagonist.
SGTC_2156 5649887 115 µM -0.418814584068437 0.34823628441599 no 2211 0.337675822742958 3237 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1405 3909-7894 12 µM -0.421073471754972 0.347457368652395 no 2212 0.336850716138591 3231 7104060
SGTC_3164 9100705 49.47 µM -0.422209399321666 0.347065918051204 no 2213 0.336436090719497 3268 17174235
SGTC_121 0557-0495 61.343 µM -0.424987542690628 0.346109233573904 no 2214 0.335422877970173 3184 3104427
SGTC_769 0302-0231 76 µM -0.425893537370771 0.345797456152246 no 2215 0.335092712139163 3259 571869 YER009W NTF2
SGTC_2129 girgensonine 121.053 µM -0.429624707501519 0.344514562765937 no 2216 0.333734330592476 3194 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_415 dibenzyl ketone 100 µM -0.431788179198424 0.34377151050717 no 2217 0.332947685829516 3223 7593
SGTC_1709 st033179 39.1045 µM -0.433599370597141 0.343149913829752 no 2218 0.332289695954732 3168 573381
SGTC_343 4130-2827 29.8 µM -0.433885009833174 0.343051921787551 no 2219 0.33218597284706 3196 1118244
SGTC_1183 1254-0324 198 µM -0.434972823052524 0.342678830809863 no 2220 0.331791077050327 3282 5799357
SGTC_1724 st037281 8.293 µM -0.435697809743248 0.342430264837608 no 2221 0.331527997534702 3138 574124 YDL195W SEC31
SGTC_599 1935-0052 86.5 µM -0.43637688122817 0.34219750304809 no 2222 0.331281654855958 3151 9557311
SGTC_3265 9137266 49.47 µM -0.439066062933716 0.341276335695408 no 2223 0.330306834301564 3235 17224265
SGTC_113 0099-0221 2.5 µM -0.439487247073089 0.341132146377776 no 2224 0.330154260321322 3338 89219
SGTC_1265 0819-1001 68.8 µM -0.440084112810265 0.340927853476755 no 2225 0.329938094041628 3267 3106768
SGTC_2536 dehydroabietamide 32.04 µM -0.440176069779042 0.340896382944854 no 2226 0.329904795121935 3321 3983547
SGTC_3016 9080866 49.47 µM -0.441660301749167 0.340388585927505 no 2227 0.329367520322079 3173 17066299
SGTC_797 k781-0471 270 µM -0.441943823940503 0.340291617981056 no 2228 0.329264928591673 3182 23738129
SGTC_1452 4194-0072 190 µM -0.44197673442444 0.340280362889771 no 2229 0.329253020855467 3305 1343545
SGTC_315 k915-0449 187 µM -0.442927481798503 0.339955277252486 no 2230 0.328909094384492 3231 20970215 YNL149C PGA2
SGTC_3076 9116187 49.47 µM -0.44300546003222 0.339928619710601 no 2231 0.328880892704446 3255 27241210
SGTC_2198 6589944 200 µM -0.443461944117727 0.339772582689802 no 2232 0.328715819796947 3237 5290268
SGTC_2902 5787006 60.46 µM -0.443617461325603 0.339719429510249 no 2233 0.328659589589075 3133 591003
SGTC_2594 a-mangostin 100 µM -0.444189113279112 0.33952407583328 no 2234 0.328452931284891 3302 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1199 1638-0010 4.46 µM -0.445283192660327 0.33915031048415 no 2235 0.328057556220384 3170 3111136
SGTC_1310 1188-0297 994 nM -0.445414395715369 0.339105498801691 no 2236 0.328010155384957 3193 1588352
SGTC_3235 9132602 49.47 µM -0.445596680479881 0.339043244219944 no 2237 0.32794430442685 3315 4912240
SGTC_2186 6124449 200 µM -0.446952613818117 0.338580298774176 no 2238 0.327454637126409 3286 3834182 YLR033W RSC58
SGTC_137 0438-0332 85.389 µM -0.4485955610821 0.338019687176023 no 2239 0.326861718254342 3300 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_3125 9127534 49.47 µM -0.448927099448468 0.337906602115921 no 2240 0.326742123182426 3236 1639235
SGTC_718 1130-0073 349 µM -0.449072572922008 0.337856986905476 no 2241 0.326689652488795 3360 6740020
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.450625872881982 0.33732739390668 no 2242 0.326129608026148 3197 2333 A French combination drug.
SGTC_821 1114-0266 29.2 µM -0.450672188135013 0.337311607799613 no 2243 0.326112915008312 3266 3123235
SGTC_1884 5633444 25 µM -0.451637493350853 0.336982658055247 no 2244 0.32576507750442 3317 5724239
SGTC_2543 pimpinellin 60.67 µM -0.452494392473723 0.336690754567071 no 2245 0.325456430008392 3169 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2351 9026858 72.31 µM -0.455587971890955 0.335637743482495 no 2246 0.32434314706081 3140 1409300
SGTC_1454 4239-0054 42.6 µM -0.456293002757108 0.335397940976451 no 2247 0.324089647479846 3372 1340767
SGTC_2894 9048625 32.47 µM -0.456763206019128 0.335238047763722 no 2248 0.323920627390783 3371 4092861
SGTC_326 k292-0812 17.5 µM -0.456929014959886 0.33518167134069 no 2249 0.323861034073136 3280 3579357
SGTC_135 0933-0004 26.348 µM -0.45783734721241 0.334872896700305 no 2250 0.323534650928684 3322 21230617 YGL099W LSG1
SGTC_2970 9090938 41.86 µM -0.458130012489345 0.334773433059695 no 2251 0.32342951895061 3365 17217104
SGTC_2063 5246145 200 µM -0.458566044043291 0.334625267230491 no 2252 0.323272912712851 3322 711240
SGTC_193 1273-0060 1.558 µM -0.459735070782153 0.334228152869652 no 2253 0.322853196567177 3269 2847393 YHR072W ERG7
SGTC_386 1509-0011 3.07 µM -0.46079372898332 0.333868690337309 no 2254 0.32247330065177 3235 3107280
SGTC_1861 st057647 17.4 µM -0.463661829832717 0.332895606323393 no 2255 0.321445024230644 3372 688668
SGTC_1065 prochlorperazine maleate 2.48 µM -0.463959005687074 0.332794845217973 no 2256 0.321338558252732 3329 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1327 1436-0082 2.18 µM -0.467514722652534 0.331590174273625 no 2257 0.320065830591702 3226 15992205
SGTC_3288 9119690 36.221 µM -0.467692412117094 0.331530018925583 no 2258 0.320002284063622 3239 17595618 YKL019W RAM2
SGTC_3043 9092303 49.47 µM -0.46965330948393 0.330866461651736 no 2259 0.319301365503045 3262 25236084
SGTC_1039 k821-0043 94 µM -0.470046013501716 0.330733636451732 no 2260 0.319161071772183 3340 15992768
SGTC_2161 5662504 8.5105 µM -0.47091895104492 0.330438457095773 no 2261 0.318849307124263 3231 2859334
SGTC_3188 9110789 49.47 µM -0.472274419516294 0.32998032144241 no 2262 0.318365463337801 3371 849217
SGTC_1164 k060-0068 93.7 µM -0.472341605240262 0.329957619920991 no 2263 0.318341488980308 3238 5963676
SGTC_3194 9111903 49.47 µM -0.474632646178839 0.329183870653527 no 2264 0.317524416488966 3387 17087251
SGTC_3253 9135987 49.47 µM -0.47659326065617 0.328522296097138 no 2265 0.316825891667072 3325 4182430
SGTC_1317 1273-0028 910 nM -0.477377554081961 0.328257800510663 no 2266 0.316546647339267 3243 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1008 4106-0037 6 µM -0.47761968076932 0.328176162942156 no 2267 0.316460460275789 3256 2905394
SGTC_3238 9133470 49.47 µM -0.478397562634821 0.327913940982346 no 2268 0.316183634041875 3362 3534688
SGTC_2667 digitoxin 100 µM -0.479465069376344 0.327554225302867 no 2269 0.315803906163062 3314 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1224 0823-0416 294 µM -0.480353103153182 0.327255108184126 no 2270 0.315488167500183 3367 3598164
SGTC_642 0335-0876 158 µM -0.481464272240296 0.326880988428519 no 2271 0.315093283198061 3280 6812350
SGTC_3093 9117344 49.47 µM -0.483184243738762 0.326302233974464 no 2272 0.314482460932192 3367 24824913
SGTC_1818 st052136 56.3 µM -0.483309183242496 0.326260209258715 no 2273 0.314438110279598 3339 674169
SGTC_1714 st033236 13.627 µM -0.484545633464879 0.325844435230114 no 2274 0.313999343341662 3423 2916566
SGTC_708 3448-5400 146 µM -0.48756591856223 0.324829732386039 no 2275 0.312928670475372 3349 3462195
SGTC_2804 7954240 19.48 µM -0.488928725430816 0.324372304857068 no 2276 0.312446079038176 3355 828705
SGTC_1161 k007-0610 110 µM -0.489824367003305 0.324071826042151 no 2277 0.312129093217984 3400 5843850
SGTC_1144 3486-0183 12.5 µM -0.491308437277238 0.323574187545979 no 2278 0.311604156626766 3301 6744069
SGTC_545 4218-0007 221 µM -0.49240348736641 0.323207197437166 no 2279 0.311217067228423 3356 2840508
SGTC_2997 9067075 71.4286 µM -0.492507772991282 0.323172256591011 no 2280 0.311180214165999 3325 27209819
SGTC_2106 5357045 167.29 µM -0.492979329325448 0.323014281357431 no 2281 0.311013596472141 3312 668842
SGTC_269 exalamide 29 µM -0.494891036957544 0.322374170910711 no 2282 0.310338518945248 3281 3316 A derivative of salicylamide.
SGTC_577 r071-0003 38.6 µM -0.495730132424453 0.322093376784581 no 2283 0.310042412310037 3272 4568517 YMR134W ERG29
SGTC_1304 1165-0502 251 µM -0.498206914739254 0.321265141228823 no 2284 0.309169104606437 3272 767425
SGTC_685 1278-0033 54.9 µM -0.499135268005049 0.320954928665343 no 2285 0.308842046665103 3402 3590572
SGTC_394 menadione 8.33 µM -0.499461897697735 0.320845813886706 no 2286 0.308727011367496 3361 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2977 9011197 71.43 µM -0.501918733131248 0.320025573408414 no 2287 0.307862343665122 3430 2704722
SGTC_2220 6782180 200 µM -0.504394556939564 0.319199882486666 no 2288 0.306992071111342 3321 833803
SGTC_1772 st048439 82.2 µM -0.504936372758717 0.319019305466983 no 2289 0.306801763081597 3343 2927068 YDL195W SEC31
SGTC_795 0685-0265 78 µM -0.506316386153322 0.318559567020667 no 2290 0.30631728079317 3420 302754
SGTC_128 0906-2981 13.371 µM -0.506430256997856 0.318521644482722 no 2291 0.306277319178527 3400 6740226
SGTC_2865 9030313 51.95 µM -0.506504029619017 0.318497076916852 no 2292 0.306251430787152 3224 42562754
SGTC_1725 st036284 20.55 µM -0.50663384903379 0.31845384673175 no 2293 0.306205876725504 3444 707914
SGTC_1427 4048-4900 550 nM -0.50859464570149 0.317801197487865 no 2294 0.305518191392449 3390 24132586
SGTC_84 0443-0269 128.823 µM -0.508777160702372 0.317740476294934 no 2295 0.305454215063295 3372 6150058
SGTC_2191 5911152 200 µM -0.511886861346855 0.316706659584683 no 2296 0.304365096998534 3330 2875902
SGTC_1851 st056236 18.9 µM -0.512722403784255 0.316429127767674 no 2297 0.304072757858547 3435 5393171
SGTC_2877 9040724 71.43 µM -0.513025209703115 0.316328573968676 no 2298 0.303966843189426 3418 6463895
SGTC_989 1501-0895 10.3 µM -0.513123065792511 0.316296081464617 no 2299 0.303932618857363 3415 2830112
SGTC_126 0417-1624 672.48 µM -0.514707325439712 0.315770235433161 no 2300 0.303378776854146 3457 41912 YDL195W SEC31
SGTC_2127 5253358 187.912 µM -0.51527738956467 0.315581111383458 no 2301 0.303179598286518 3260 20612
SGTC_1438 4092-1045 4 µM -0.515718363909101 0.31543484718567 no 2302 0.303025563397588 3320 1351342
SGTC_1245 0418-0076 17.2 µM -0.516185227370531 0.315280027489057 no 2303 0.302862523462144 3411 6790114
SGTC_1751 st044839 27.194 µM -0.516227984246012 0.315265850218051 no 2304 0.302847593697473 3405 5291326
SGTC_10 0279-0212 42.575 µM -0.516727858280248 0.315100122800315 no 2305 0.302673073082379 3355 39851 YBR002C RER2
SGTC_1371 2421-0008 32.7 µM -0.517469865451319 0.314854187579182 no 2306 0.302414099841019 3285 2827552
SGTC_1530 rhein 70.4 µM -0.51793221944127 0.314700983754361 no 2307 0.302252780629016 3394 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1181 1222-0449 220 µM -0.518099165263645 0.314645673069485 no 2308 0.302194541311808 3453 658318
SGTC_929 2805-0021 398 µM -0.51981482589876 0.314077500103746 no 2309 0.301596322441436 3388 3098024
SGTC_1677 st019204 53.9 µM -0.521472895050344 0.313528818034289 no 2310 0.301018691352059 3350 3945625
SGTC_2300 7976697 71.57 µM -0.521664729429606 0.31346536350585 no 2311 0.300951893104605 3254 2236109
SGTC_656 4090-1979 187 µM -0.522252314324734 0.313271037901028 no 2312 0.300747332999463 3433 22330961
SGTC_597 k018-0003 82.8 µM -0.522491105938123 0.31319207974098 no 2313 0.300664218711473 3427 6786234
SGTC_1729 st035615 45.989 µM -0.523499445907685 0.312858759364201 no 2314 0.300313368259522 3351 17385451
SGTC_1559 coumarin 343 70.1 µM -0.524860530657958 0.312409077016523 no 2315 0.299840074452542 3443 108770 A hepatotoxic, DNA x-linker.
SGTC_237 nikkomycin 200 µM -0.527145699032027 0.311654719200608 no 2316 0.299046206883041 3456 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_578 3460-0051 92 µM -0.527266285528438 0.31161493425526 no 2317 0.299004341651128 3462 2876744
SGTC_364 0083-0097 67.7 µM -0.527454542953261 0.311552827125449 no 2318 0.298938987741147 3424 5207356
SGTC_613 3914-0030 117 µM -0.527474879466031 0.311546118322111 no 2319 0.298931928271802 3231 1145395
SGTC_3270 9137563 49.47 µM -0.528262380762991 0.31128637799928 no 2320 0.298658619053915 3374 17015724
SGTC_901 1112-0062 60.1 µM -0.528648280506562 0.31115913157207 no 2321 0.298524730663153 3351 1908457
SGTC_296 1222-0039 74.9 µM -0.530094979385229 0.310682298636691 no 2322 0.2980230399366 3357 5984176
SGTC_1596 piperlongumine 63 µM -0.532650661518592 0.309840721080036 no 2323 0.297137712836699 3461 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2802 7925815 54.55 µM -0.532989538229273 0.309729204781511 no 2324 0.297020411143553 3322 1262923
SGTC_2730 imipramine 71.33 µM -0.533721652002446 0.309488343267366 no 2325 0.296767063334213 3449 3696 A tricyclic antidepressant.
SGTC_2983 9022671 12.99 µM -0.534692608486803 0.309169029988981 no 2326 0.296431216749788 3453 6405161
SGTC_3071 9117417 49.47 µM -0.534752577284796 0.309149313092868 no 2327 0.296410479704369 3301 45595590 YGL055W OLE1
SGTC_2291 7917025 104.35 µM -0.535772377842664 0.308814101228195 no 2328 0.29605793732803 3301 2964612
SGTC_2289 7946404 165.07 µM -0.535806267880046 0.30880296419102 no 2329 0.296046224935684 3341 1246120 YPR165W RHO1
SGTC_3175 9106517 49.47 µM -0.538670493763843 0.307862350598247 no 2330 0.295057118367067 3405 41468073
SGTC_595 3909-8003 73.7 µM -0.538735999832218 0.307840853092792 no 2331 0.295034514892013 3445 699517
SGTC_1159 4092-0538 61.2 µM -0.538948904122589 0.307770987615807 no 2332 0.294961055806233 3422 717301
SGTC_1404 3909-7820 48.3 µM -0.538982358542145 0.307760010034796 no 2333 0.294949513681156 3434 23741373
SGTC_719 2810-4230 27.3 µM -0.539381664678967 0.307628996823341 no 2334 0.294811764951738 3373 721079
SGTC_3149 9097855 49.47 µM -0.541301262933916 0.306999515113674 no 2335 0.294149975067433 3421 25236625 YMR079W SEC14
SGTC_1978 st071761 42 µM -0.541342130120878 0.306986119969609 no 2336 0.294135893391916 3330 5147680
SGTC_1124 fisetin 1.16336 µM -0.541346040473822 0.306984838276569 no 2337 0.294134546011338 3365 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1989 st071868 50.2 µM -0.541854011094918 0.306818361240975 no 2338 0.293959540095411 3438 16414057
SGTC_80 0159-0065 512.242 µM -0.542218539600048 0.306698918987706 no 2339 0.293833982503531 3412 1548079
SGTC_36 0335-0881 14.2 µM -0.542236606059807 0.306692999823409 no 2340 0.293827760367484 3394 23828853
SGTC_227 fluconazole 33.516 µM -0.542320233030359 0.306665601543983 no 2341 0.293798959813954 3390 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_158 k038-0087 26.446 µM -0.544128973410902 0.3060732776938 no 2342 0.29317636193853 3354 X158
SGTC_2429 5902844 64.44 µM -0.547764690920721 0.304884191751674 no 2343 0.291926743083128 3413 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_3060 1327-0027 12.5 µM -0.547853714399491 0.304855101782202 no 2344 0.291896176292481 3380 16000455 YPR107C YTH1
SGTC_2860 9025725 38.96 µM -0.548219954247106 0.304735439521456 no 2345 0.291770441141655 3319 40546248
SGTC_74 000s-0487 160.283 µM -0.548401922503213 0.304675992443974 no 2346 0.291707978335497 3429 677548
SGTC_671 0560-0003 407 µM -0.548819768577059 0.304539506134026 no 2347 0.291564571204907 3354 3238678
SGTC_2334 9017922 200 µM -0.548968519977295 0.30449092416292 no 2348 0.291513526820687 3410 3163164
SGTC_382 3229-0966 23.2 µM -0.549282572527324 0.304388366427387 no 2349 0.291405772658132 3496 5722370
SGTC_853 0419-0306 21 µM -0.549331380857772 0.304372428845536 no 2350 0.291389027763837 3354 762713
SGTC_443 clozapine 122 µM -0.549384670783122 0.304355028294596 no 2351 0.29137074586123 3399 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_427 1354-0053 47.3 µM -0.549618184366162 0.304278785240454 no 2352 0.291290641860249 3516 6813657
SGTC_17 0960-0276 49.807 µM -0.549776116282647 0.304227224704068 no 2353 0.291236471060169 3425 6821114
SGTC_171 k064-0041 9.68 µM -0.550201839258929 0.304088256955306 no 2354 0.291090471097208 3354 53325
SGTC_700 3453-2283 142 µM -0.550327102502248 0.304047372957024 no 2355 0.291047519087384 3494 565664
SGTC_222 nsc-310342 10.666 µM -0.551866738259941 0.303545059769123 no 2356 0.290519829273881 3424 432556
SGTC_2023 5144124 124 µM -0.553016477339649 0.303170194034873 no 2357 0.290126063648872 3347 2830192
SGTC_666 0272-0154 136 µM -0.55459131028906 0.30265706520746 no 2358 0.289587117045168 3396 6870312
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.554983047929016 0.302529485543678 no 2359 0.28945312782031 3395 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1611 st001856 99.4 µM -0.556807258403127 0.301935701221 no 2360 0.288829562068335 3393 647478
SGTC_1 0258-0098 57.368 µM -0.557563649668454 0.301689647934966 no 2361 0.28857119213081 3380 6790032 YDR047W HEM12
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.557626462791469 0.301669218947105 no 2362 0.288549741171656 3452 140250 A respiratory chain inhibitor.
SGTC_380 3970-0968 6 µM -0.558961436449019 0.301235186797501 no 2363 0.288094019530501 3381 2891601
SGTC_3063 1327-0034 4 µM -0.559472510291217 0.301069098844197 no 2364 0.287919643557463 3416 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2374 9071832 200 µM -0.560073215530081 0.300873935406107 no 2365 0.287714749512736 3457 17381698
SGTC_819 1013-0258 27.7 µM -0.560471658795243 0.300744516449857 no 2366 0.287578882850857 3415 5753198
SGTC_1696 st025591 34.7925 µM -0.560752504941131 0.300653309486553 no 2367 0.287483134298666 3448 2787147
SGTC_527 4476-4215 268 µM -0.561982215832291 0.300254098446608 no 2368 0.287064067999254 3349 4418754
SGTC_1785 bathophenanthroline 24 µM -0.562276141225572 0.300158714550944 no 2369 0.286963945660236 3354 72812 An iron chelator.
SGTC_1853 st056710 91.2 µM -0.562421565567592 0.300111526893349 no 2370 0.286914414631567 3510 269167
SGTC_3069 9117009 49.47 µM -0.564359858981894 0.299482905212705 no 2371 0.286254625692778 3352 41904981
SGTC_2273 7815444 169.05 µM -0.565188138245379 0.299214462249232 no 2372 0.285972901941664 3474 2824616
SGTC_2444 5485484 36.41 µM -0.56523425867099 0.299199517959533 no 2373 0.285957218812782 3499 6790631
SGTC_23 0213-0011 39.996 µM -0.567153285287572 0.29857800091694 no 2374 0.285305021570663 3508 627608
SGTC_2625 euphol 100 µM -0.567445608402742 0.298483377500489 no 2375 0.285205735341484 3488 6708538 A triterpene alcohol.
SGTC_1608 st001473 40.5 µM -0.567560086953122 0.298446325128986 no 2376 0.285166857704605 3364 7292267
SGTC_3041 9091929 49.47 µM -0.567719378168259 0.298394772077469 no 2377 0.285112765607173 3547 25236887
SGTC_2566 crystal violet carbinol 226 nM -0.568166715132294 0.298250017500078 no 2378 0.284960885118299 3444 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_154 3389-1638 511.116 µM -0.572186190905944 0.296950785091622 no 2379 0.283597920889041 3400 5238686
SGTC_3006 9075424 71.4286 µM -0.572657575181105 0.296798587315596 no 2380 0.283438284016917 3405 7465181
SGTC_1165 k072-0275 30.3 µM -0.573029570360809 0.296678504918879 no 2381 0.283312336223907 3524 6153523 YGL055W OLE1
SGTC_665 3914-0008 307 µM -0.574074913305631 0.296341180771998 no 2382 0.282958554318586 3411 1069549
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.574846889911048 0.29609218278692 no 2383 0.282697425711839 3465 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1591 genipin 88.4 µM -0.575370011891537 0.295923506465967 no 2384 0.282520540453715 3488 442424 A DNA cross-linking agent.
SGTC_1743 st037606 46.3785 µM -0.577271277356733 0.295310831197183 no 2385 0.281878106766257 3455 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1984 st072354 53.1 µM -0.578834410265609 0.29480755548042 no 2386 0.281350455167451 3397 5762938
SGTC_2785 7756463 72.73 µM -0.578841062604934 0.294805414498256 no 2387 0.281348210620998 3406 2201551
SGTC_2093 5331342 194.4 µM -0.579557594425902 0.294574848600708 no 2388 0.281106498320148 3503 33839
SGTC_485 niflumic acid 177 µM -0.580632975532406 0.294228968260664 no 2389 0.280743921430777 3500 4488 A COX2 inhibitor.
SGTC_3068 9116768 49.47 µM -0.580638307954591 0.294227253633916 no 2390 0.280742124108073 3476 41904888
SGTC_3129 9127257 49.47 µM -0.581475397490834 0.293958146886574 no 2391 0.280460047427193 3363 837894
SGTC_2765 myclobutanil 7.74 µM -0.582269822434658 0.293702861219454 no 2392 0.280192474516081 3501 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1612 st002233 45.4 µM -0.584353200333067 0.293033862908001 no 2393 0.279491353130326 3507 1035021
SGTC_370 0180-0345 38.7 µM -0.585129012793166 0.292784920731188 no 2394 0.279230486003444 3422 3989527
SGTC_513 4245-1575 41.7 µM -0.586023123666932 0.292498140896701 no 2395 0.278929987862799 3461 719745
SGTC_678 1218-2179 85.9 µM -0.586500366845852 0.292345121931105 no 2396 0.278769657538542 3484 6820081 YOR116C RPO31
SGTC_2514 salinomycin 42.74 µM -0.586979936334879 0.292191394587393 no 2397 0.278608590887434 3529 23682228 A polyether potassium ionophore.
SGTC_3225 9130819 49.47 µM -0.58758180458187 0.291998517273151 no 2398 0.278406513524473 3517 4547121
SGTC_204 PMA1.184 62.41 µM -0.589980813229127 0.291230310204914 no 2399 0.277601756448721 3502 2252213 YGL008C PMA1
SGTC_1167 k781-0610 148 µM -0.59018691876694 0.291164355423532 no 2400 0.2775326705708 3488 4525169
SGTC_1867 st057372 64 µM -0.59070464063831 0.290998712660897 no 2401 0.277359169023007 3500 688837
SGTC_1674 st016616 23.6 µM -0.593924147350299 0.289969635632639 no 2402 0.276281423728554 3472 625830
SGTC_3073 9114972 49.47 µM -0.59458248483844 0.289759416202825 no 2403 0.276061295407679 3463 41905075
SGTC_1697 st025554 27.742 µM -0.595221358447618 0.289555480347985 no 2404 0.275847757590267 3496 1269519
SGTC_3334 9142812 21.919 µM -0.596207425141967 0.289240848791941 no 2405 0.275518332950798 3520 45283678
SGTC_2511 berberine 10.47 µM -0.596525899403035 0.28913926520973 no 2406 0.275411978592138 3496 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1804 st050076 49.1 µM -0.596686905207732 0.289087915650665 no 2407 0.275358218452975 3520 3895976
SGTC_3152 9099253 49.47 µM -0.59673479357502 0.28907264344787 no 2408 0.275342229434062 3518 25236131
SGTC_2202 7226349 200 µM -0.597870841525298 0.288710454791385 no 2409 0.274963058577481 3458 844334
SGTC_2709 st078560 56 µM -0.598195193666378 0.288607085827818 no 2410 0.27485484904104 3560 17250903
SGTC_2575 plumbagin 510 nM -0.599397632533361 0.288224028412235 no 2411 0.274453877674988 3469 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_755 1995-0008 37.3 µM -0.600548075530375 0.287857759806767 no 2412 0.27407051553384 3529 689533
SGTC_2676 harmalol 100 µM -0.601154775211372 0.287664692309512 no 2413 0.273868451600611 3547 5459187 A monoamine oxidase inhibitor
SGTC_2417 cerulenin 830 nM -0.602190516207172 0.287335234278718 no 2414 0.27352366390951 3578 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_120 rhodamine 6G 52.259 µM -0.603957308259106 0.28677364915401 no 2415 0.272936012992308 3500 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_3325 9138760 55.175 µM -0.604096639827701 0.286729383947144 no 2416 0.272889696706165 3453 43844959
SGTC_1093 fluphenazine 7.97 µM -0.607264083464894 0.285723971847528 no 2417 0.271837834954583 3550 6602611 An atypical antipsychotic.
SGTC_1548 st061468 90.8 µM -0.607334278113989 0.285701709622475 no 2418 0.271814547206159 3499 390799
SGTC_706 4262-0057 46.9 µM -0.607390286866026 0.285683947044997 no 2419 0.271795966477304 3506 883298
SGTC_2395 5646831 180.19 µM -0.608872034726112 0.285214217461345 no 2420 0.271304630919609 3552 6808628
SGTC_1312 1218-2183 165 µM -0.609458152210646 0.285028513718973 no 2421 0.271110401379267 3550 6744073
SGTC_880 0833-0487 87.2 µM -0.610751518456781 0.284618931456324 no 2422 0.270682046906734 3515 76075
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.610848006901128 0.284588386835372 no 2423 0.270650104114986 3567 551469
SGTC_2745 rifampicin 24.3 µM -0.611027290759369 0.284531636449768 no 2424 0.270590756649798 3461 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1875 nocodazole 6 µM -0.61137982078052 0.284420062611929 no 2425 0.270474079308873 3557 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_886 0866-0150 153 µM -0.61229553216331 0.284130342642161 no 2426 0.270171122574492 3587 271463
SGTC_321 4534-3890 65.3 µM -0.612939287853629 0.283926750679046 no 2427 0.269958242132747 3530 699746
SGTC_2212 7123476 200 µM -0.613214257723384 0.283839810936715 no 2428 0.269867339276068 3493 1085715
SGTC_1457 k015-0032 57.3 µM -0.613338485204768 0.28380053697585 no 2429 0.269826275682623 3545 4302660
SGTC_2224 6650123 117.647 µM -0.613725652568522 0.283678152443749 no 2430 0.269698316960672 3508 2908370
SGTC_3251 9135047 49.47 µM -0.614911613174661 0.283303424842922 no 2431 0.269306546502562 3510 17682963
SGTC_162 k030-0015 37.8 µM -0.615148833611991 0.283228498875678 no 2432 0.269228217322651 3551 1809920 YMR134W ERG29
SGTC_761 k216-0224 480 µM -0.615335316636454 0.283169604971242 no 2433 0.26916664944464 3612 1340404
SGTC_3062 9077494 49.47 µM -0.61575523936919 0.283037009111242 no 2434 0.269028036678227 3512 16459633
SGTC_1742 st038235 28.8875 µM -0.616383461728781 0.282838695697159 no 2435 0.268820732968687 3521 564103 YBR002C RER2
SGTC_956 1185-0240 191 µM -0.61856211111585 0.282151470434976 no 2436 0.268102434311239 3531 1416193
SGTC_2400 5203494 178.7 µM -0.620705408821313 0.281476181726217 no 2437 0.267396734989835 3541 6777674
SGTC_123 0083-0120 66.675 µM -0.620888418846202 0.281418556919222 no 2438 0.267336520802535 3486 16001701
SGTC_439 amiodarone 34.4 µM -0.62193981298521 0.28108761226084 no 2439 0.26699072238372 3481 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_3190 9110366 49.47 µM -0.622212951205492 0.281001668013732 no 2440 0.266900925531563 3490 17123768
SGTC_221 trifluoperazine 10.304 µM -0.622944870902899 0.280771428604136 no 2441 0.266660375040917 3575 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.623040474893555 0.280741361268819 no 2442 0.266628962220793 3533 2724 A muscle relaxant with antifungal properties.
SGTC_2381 9035592 200 µM -0.623054564270674 0.280736930309021 no 2443 0.266624333000371 3508 4749657
SGTC_1005 4092-0690 4.4 µM -0.625519039703784 0.279962399737441 no 2444 0.265815228108728 3503 1529343
SGTC_2856 9022925 19.48 µM -0.626020440437503 0.279804947416946 no 2445 0.265650767147268 3549 4944862
SGTC_186 3455-3465 67.277 µM -0.626436032514381 0.279674473719727 no 2446 0.265514490804661 3522 755278
SGTC_2703 st077852 53.4 µM -0.627111537346923 0.279462464331621 no 2447 0.265293062450885 3562 6281836
SGTC_181 1447-1644 8.07 µM -0.627896601315279 0.279216167561092 no 2448 0.265035838791727 3526 534600
SGTC_3219 9131112 49.47 µM -0.628019492077561 0.279177622805509 no 2449 0.264995585504875 3513 17612988 YMR079W SEC14
SGTC_1284 0929-0043 16 µM -0.630195411015515 0.278495573307439 no 2450 0.264283370663569 3512 1239883
SGTC_1344 1488-0097 29.1 µM -0.63305429017854 0.277600683296778 no 2451 0.26334909530417 3567 747966
SGTC_1286 0929-0070 131 µM -0.633919177334819 0.277330232286134 no 2452 0.263066784736013 3618 1420408
SGTC_1243 0416-0003 5.65 µM -0.63417319219126 0.277250826091317 no 2453 0.26298390033002 3527 2141977
SGTC_2489 cantharidin 73.42 µM -0.635639009976876 0.276792822179785 no 2454 0.262505868597695 3576 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3180 9109287 49.47 µM -0.636112416108318 0.276644982697533 no 2455 0.262351576715271 3573 18891271
SGTC_1814 st052110 31.539 µM -0.636626824186845 0.27648438264569 no 2456 0.262183974200746 3583 674163
SGTC_556 4058-0063 51.5 µM -0.637717462907962 0.276144032599572 no 2457 0.261828807928134 3610 6615692
SGTC_876 0720-0963 56.8 µM -0.637833710547438 0.27610776792535 no 2458 0.261790966467049 3611 765861
SGTC_1017 4239-0030 168 µM -0.637865127551824 0.276097967461612 no 2459 0.261780739942271 3521 1149593
SGTC_3294 9122953 26.2835 µM -0.63887174848682 0.275784044758204 no 2460 0.261453184050533 3588 16459826
SGTC_2801 7907800 81.82 µM -0.639776024545296 0.275502188756379 no 2461 0.261159110879068 3581 6620925
SGTC_2771 fluoxetine 41.05 µM -0.640292948855212 0.275341131034844 no 2462 0.260991082002419 3596 3386 A selective serotonin reuptake inhibitor.
SGTC_1504 k297-0033 30 µM -0.642346914970967 0.274701636543353 no 2463 0.260323979554356 3468 4388117
SGTC_2379 9035213 200 µM -0.642795243382558 0.274562148650649 no 2464 0.260178484995254 3609 646551
SGTC_3252 9135871 49.47 µM -0.645641345334442 0.273677460156835 no 2465 0.25925582733675 3608 17682838
SGTC_1552 6-methylflavone 10.6 µM -0.64572418570286 0.273651731013564 no 2466 0.25922899725172 3568 689013
SGTC_1710 st031758 61.5 µM -0.645848801802649 0.273613029124637 no 2467 0.259188639673934 3618 5394341
SGTC_3095 9117207 49.47 µM -0.646283722869476 0.273477977378564 no 2468 0.259047813655933 3561 17015229
SGTC_640 3381-0960 37.1 µM -0.646443500310115 0.273428371556317 no 2469 0.258996088183462 3626 1745025
SGTC_19 0279-0214 38.434 µM -0.646523088495986 0.273403663613916 no 2470 0.258970324733875 3639 3566274 YBR002C RER2
SGTC_1994 st072947 40.9 µM -0.647695543529143 0.273039806191768 no 2471 0.258590943593039 3617 5286565 YDL195W SEC31
SGTC_1667 st014849 34.6 µM -0.648143922880069 0.272900720492475 no 2472 0.258445933824242 3625 5348460
SGTC_473 2-arachidonoylglycerol 10 µM -0.648650057606148 0.272743761506548 no 2473 0.258282296093915 3517 5282280 An endocannabinoid.
SGTC_2523 spermine 47.74 µM -0.649301431557166 0.272541827878456 no 2474 0.258071780316826 3569 1103 A DNA binding polyamine.
SGTC_1424 4048-1941 275 µM -0.649654434989303 0.272432423661662 no 2475 0.25795773128604 3642 X1424
SGTC_1646 st011709 75.6 µM -0.649683670552145 0.272423363838753 no 2476 0.25794828697644 3577 5757843
SGTC_3262 9137218 49.47 µM -0.649737715093305 0.272406616343381 no 2477 0.25793082880149 3469 17650664
SGTC_2621 lithochol-11-enic acid 100 µM -0.649945517106765 0.27234222675405 no 2478 0.257863707586029 3597 6708711
SGTC_2978 9011784 42.97 µM -0.650834987850886 0.272066700580494 no 2479 0.257576506010258 3645 2994934
SGTC_2507 purpurin 79.67 µM -0.651227057530044 0.27194529546473 no 2480 0.257449963241522 3555 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2414 st077232 92.9 µM -0.651265848327821 0.271933285286113 no 2481 0.257437445042048 3554 729801
SGTC_1080 nisoldipine 24.4 µM -0.651307297607089 0.271920452295686 no 2482 0.257424069272063 3575 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_417 st075190 100 µM -0.651554512445847 0.271843919087886 no 2483 0.257344300021058 3614 222757
SGTC_569 4130-2812 160 µM -0.653209371482078 0.271331881062898 no 2484 0.256810654707288 3521 743552
SGTC_1651 st011928 86.1 µM -0.655347498471351 0.270671025203494 no 2485 0.256122022922276 3602 720198
SGTC_2213 7173844 200 µM -0.655567095094979 0.270603197455977 no 2486 0.25605135147272 3583 892728
SGTC_2581 avocatin a 64 µM -0.655976559935391 0.270476746978849 no 2487 0.255919603057621 3592 6710728 A skin care supplement.
SGTC_2344 7990960 76.95 µM -0.657900379311534 0.26988303074418 no 2488 0.255301073456527 3587 140813
SGTC_3339 9145883 14.936 µM -0.659403144122836 0.26941971182834 no 2489 0.254818461832134 3546 2030670
SGTC_826 1683-5028 118 µM -0.660993988063335 0.268929672013829 no 2490 0.254308084525784 3628 722377
SGTC_1827 berberine 7.24 µM -0.661226321048563 0.268858142176734 no 2491 0.254233591927312 3535 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_759 3486-0358 89.3 µM -0.662926772606123 0.268334904350132 no 2492 0.253688727046361 3643 875103
SGTC_2014 4013930 200 µM -0.662995781615623 0.268313680737089 no 2493 0.253666627883952 3594 64556
SGTC_1800 st050079 29.0735 µM -0.663748612408106 0.268082203667773 no 2494 0.253425610127486 3588 3645560
SGTC_1192 1488-0095 21.4 µM -0.664450166794494 0.267866583362076 no 2495 0.253201116823377 3605 915875
SGTC_1540 guanosine 70.6 µM -0.66452084388843 0.267844865847014 no 2496 0.253178506366248 3571 6802 Guanosine is a purine nucleoside
SGTC_892 0929-0076 29 µM -0.66509003731474 0.267669997578298 no 2497 0.252996453223152 3617 5751038
SGTC_2053 5265679 138 µM -0.666723909738409 0.26716835723782 no 2498 0.252474251710749 3604 764595
SGTC_2135 5326629 150.42 µM -0.667251575509031 0.267006451877353 no 2499 0.252305726019409 3594 5020077
SGTC_462 ag-879 158 µM -0.667274960394406 0.266999277765671 no 2500 0.25229825873633 3630 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_628 1636-0253 16 µM -0.668238441583794 0.266703781685828 no 2501 0.251990700362151 3599 4456143
SGTC_3295 9122362 53.5725 µM -0.669167558682148 0.26641898159994 no 2502 0.251694299034007 3617 4730473
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.669296655000611 0.266379422186004 no 2503 0.251653130079517 3633 16623 A steroid.
SGTC_368 fentichlor 4.58 µM -0.672549769980451 0.265383541448663 no 2504 0.250616883384123 3594 7329 A pesticide.
SGTC_3080 9117754 49.47 µM -0.672579363592507 0.265374490594199 no 2505 0.250607467025577 3684 9550191
SGTC_616 4092-0450 108 µM -0.673330771446369 0.265144733934255 no 2506 0.250368440202074 3655 787165
SGTC_986 1493-0483 84 µM -0.674594481239202 0.264758559563913 no 2507 0.249966720103585 3589 40079
SGTC_610 4215-0184 155 µM -0.676568042989833 0.264156035648673 no 2508 0.249340030390777 3660 5605015
SGTC_1092 toremifene 6.32 µM -0.676615266781841 0.264141626893347 no 2509 0.249325045069108 3644 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2407 paclitaxel 400 µM -0.678587521708607 0.26354021722497 no 2510 0.248699625738079 3717 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_778 3456-2434 196 µM -0.679375199979194 0.263300221925726 no 2511 0.248450079722565 3681 5539063
SGTC_2834 9001755 58.44 µM -0.682956399360042 0.262210486222214 no 2512 0.247317196934545 3589 2989575
SGTC_1877 wortmannin 25 µM -0.685786901188268 0.261350820776418 no 2513 0.246423748777259 3652 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2003 4023581 200 µM -0.686738948798892 0.261061995472887 no 2514 0.24612362406662 3678 16641307
SGTC_1241 0364-0022 50.8 µM -0.688014488724247 0.260675288769248 no 2515 0.245721828711109 3659 4563895
SGTC_762 1165-0429 115 µM -0.688029581203503 0.260670714932752 no 2516 0.245717076686011 3648 5967793
SGTC_2674 ligustilide 100 µM -0.688044830956916 0.260666093475643 no 2517 0.245712275191616 3627 5319022 A signalling regulator.
SGTC_2811 7967822 32.47 µM -0.688072034146876 0.260657849619138 no 2518 0.24570371019696 3674 2232244
SGTC_2069 5228469 200 µM -0.6881495959648 0.260634345447172 no 2519 0.245679290538347 3618 2835210
SGTC_2707 st078556 66.6 µM -0.688447089259115 0.260544203815893 no 2520 0.245585639469198 3643 17250899
SGTC_648 0375-0473 33.3 µM -0.689368597518143 0.260265085111606 no 2521 0.24529566984321 3668 1713139
SGTC_2669 eugenol 100 µM -0.689755804291106 0.260147848752927 no 2522 0.245173883004062 3628 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2809 7964133 12.99 µM -0.689779472477913 0.260140683511083 no 2523 0.245166439783794 3670 1253665
SGTC_1526 st051518 75 µM -0.690821768045801 0.259825242728365 no 2524 0.244838777057312 3646 673993
SGTC_724 3910-0327 137 µM -0.690863700034666 0.259812556543726 no 2525 0.244825599981773 3658 2885483
SGTC_3182 9108849 49.47 µM -0.691119196178968 0.259735265155264 no 2526 0.244745318884378 3684 17133045
SGTC_2055 5235184 200 µM -0.691562832885164 0.259601086641621 no 2527 0.24460595459921 3663 2836034
SGTC_657 3534-0529 86.7 µM -0.691919135720673 0.259493348292463 no 2528 0.244494056380104 3682 1049549
SGTC_582 0987-0078 156 µM -0.692599040450798 0.259287823752083 no 2529 0.244280606335997 3714 1625765
SGTC_3199 9111318 49.47 µM -0.693722982099837 0.258948258367972 no 2530 0.243927975238427 3623 8548020
SGTC_2082 5219693 150 µM -0.69385051773256 0.258909741824449 no 2531 0.243887978926935 3673 2834649
SGTC_250 brefeldin a 552.239 µM -0.694385307714505 0.258748264245726 no 2532 0.243720302559881 3569 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_712 r015-0009 80.6 µM -0.695436990469343 0.258430865186154 no 2533 0.243390742875293 3652 6813872 YLR060W FRS1
SGTC_1024 4507-0395 26 µM -0.696974677696138 0.257967152735685 no 2534 0.242909320549964 3699 4201836
SGTC_491 tetrandrine 80.3 µM -0.698327975705396 0.2575594029804 no 2535 0.242486053796617 3652 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1486 3970-0793 4.53 µM -0.701508269078469 0.2566024973518 no 2536 0.241492937980295 3715 2844330
SGTC_2999 9069765 71.4286 µM -0.701827179303701 0.25650664398632 no 2537 0.241393473330298 3699 2097066
SGTC_539 4859-0462 2.54 µM -0.704156104890342 0.255807215534003 no 2538 0.240667781791642 3698 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_344 k064-0035 6.43 µM -0.704227167024763 0.25578588964773 no 2539 0.240645657566606 3655 5088750
SGTC_2030 5175110 200 µM -0.704317226219646 0.255758864039727 no 2540 0.240617620456931 3711 2831986
SGTC_32 0928-0142 34.1 µM -0.705497679243894 0.255404763119906 no 2541 0.240250287843307 3654 2244242
SGTC_1051 3253-3903 78 µM -0.706729383890757 0.255035561547523 no 2542 0.239867332779267 3684 5509239
SGTC_2311 7694451 200 µM -0.707952278524348 0.254669277166837 no 2543 0.239487446520897 3659 2163142
SGTC_2928 9011484 9.79 µM -0.709343373981789 0.254252948047409 no 2544 0.239055709191098 3695 2994751
SGTC_1131 3454-3128 32.3 µM -0.710558395130912 0.253889606881217 no 2545 0.238678966261933 3758 710982
SGTC_1453 4237-0541 195 µM -0.710712866300345 0.25384343319857 no 2546 0.238631092507036 3641 739892
SGTC_1798 st045719 60.953 µM -0.710760502602778 0.253829194903205 no 2547 0.238616330108976 3626 3980186
SGTC_1471 k673-0312 37 µM -0.710858927402617 0.253799777462378 no 2548 0.238585830036974 3680 24099884
SGTC_601 0986-0029 62.9 µM -0.713383417110709 0.253045864029868 no 2549 0.2378042658501 3682 24747981
SGTC_2808 7946468 45.46 µM -0.715130859003815 0.252524698984882 no 2550 0.237264093639653 3705 2970879
SGTC_2555 cholic acid 100 µM -0.715445524462084 0.2524309118477 no 2551 0.237166895370583 3734 6708657 Influences liver metabolism.
SGTC_1896 st058441 89 µM -0.717795811968763 0.251730981495405 no 2552 0.236441598022036 3706 688759
SGTC_187 1488-2104 32.728 µM -0.717895173133243 0.251701413713284 no 2553 0.236410962146391 3745 2852859
SGTC_220 paclitaxel 373.376 µM -0.717920407879791 0.251693904678224 no 2554 0.236403181903598 3652 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1675 st018485 24.5 µM -0.718351750728636 0.251565569453942 no 2555 0.236270214369262 3748 3323024
SGTC_655 k060-0012 42 µM -0.718750736572325 0.251446892028621 no 2556 0.236147258014202 3686 5994525
SGTC_2722 naftopidil 47.16 µM -0.718796400841908 0.251433311183471 no 2557 0.236133187802883 3660 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_911 3456-4043 236 µM -0.719696766766138 0.251165615809063 no 2558 0.235855858702359 3790 914281
SGTC_1872 amphotericin b 148 nM -0.720005810416751 0.251073766201805 no 2559 0.235760709038872 3718 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1603 st002045 67.8 µM -0.720591924950592 0.25089961830405 no 2560 0.235580311773065 3709 5887985
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.722690350731191 0.250276653078576 no 2561 0.23493507255596 3569 6708630 An antioxidant.
SGTC_1652 st011932 78 µM -0.723254898982683 0.250109194254371 no 2562 0.234761648010421 3664 1551076
SGTC_2986 9022445 71.43 µM -0.723579585928601 0.250012911090863 no 2563 0.234661938936394 3643 6459286
SGTC_1916 st067606 49.2 µM -0.723637276342446 0.249995805545259 no 2564 0.234644225067116 3732 19590279
SGTC_3201 9113999 49.47 µM -0.724334466461601 0.24978913370322 no 2565 0.234430210982776 3727 16649224
SGTC_1741 st038134 10.228 µM -0.724689438631142 0.249683942243131 no 2566 0.234321287889127 3764 1272587
SGTC_78 0336-0123 156.75 µM -0.724795900251707 0.249652398290958 no 2567 0.2342886256368 3594 6765896
SGTC_3028 9087778 49.47 µM -0.725928683803879 0.249316892308864 no 2568 0.233941245589661 3697 17217395
SGTC_1128 3448-9350 235 µM -0.725936235494475 0.249314656466095 no 2569 0.233938930741822 3760 619386
SGTC_1292 0kpi-0043 232 µM -0.726962243665168 0.249010983497292 no 2570 0.233624542649175 3739 3333905
SGTC_235 0330-0087 5 mM -0.726985892293533 0.249003986411097 no 2571 0.233617299030236 3746 46494818 YHR062C RPP1
SGTC_1274 0865-0114 173 µM -0.727337952013221 0.248899832395942 no 2572 0.233509477209871 3732 870624
SGTC_3290 9121031 71.43 µM -0.727825815659668 0.248755540228725 no 2573 0.233360109709145 3725 17014854
SGTC_1162 k048-0130 20.1 µM -0.729027456368881 0.248400329040103 no 2574 0.232992433782475 3713 6797406
SGTC_1688 st021091 57.6 µM -0.731655226440645 0.247624489646321 no 2575 0.232189515471383 3753 3656366
SGTC_2842 9000675 19.48 µM -0.731780149433995 0.247587638850414 no 2576 0.232151383480965 3715 2989072
SGTC_2568 diosmetin 100 µM -0.73242483815486 0.247397509931352 no 2577 0.231954651554034 3716 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_512 prima-1 270 µM -0.733245319285206 0.247155649944945 no 2578 0.23170440948137 3740 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_774 k060-0086 136 µM -0.733502541734695 0.247079852408208 no 2579 0.231625989082964 3740 5911235
SGTC_1242 0402-0103 60.1 µM -0.733605354959995 0.247049559195478 no 2580 0.231594648157554 3692 432868
SGTC_1961 st076550 68.7 µM -0.734143065654579 0.246891158797584 no 2581 0.231430774384319 3714 1579337
SGTC_2162 5663267 200 µM -0.734476994559937 0.246792816405688 no 2582 0.231329038105167 3714 6456493
SGTC_2326 6164455 177.58 µM -0.73673443907085 0.24612854721615 no 2583 0.230641929621408 3736 2888790
SGTC_2313 7726885 200 µM -0.737533100023704 0.245893765373385 no 2584 0.230399110970077 3731 726423
SGTC_1160 4092-0570 10.5 µM -0.738204128175765 0.245696596617626 no 2585 0.230195207335261 3720 4994975
SGTC_630 4356-0227 183 µM -0.740821081984907 0.244928466732031 no 2586 0.229400965381071 3732 779312
SGTC_893 0958-0369 48.9 µM -0.742155966585234 0.24453714883708 no 2587 0.22899642201374 3754 6819948
SGTC_3133 9127736 49.47 µM -0.743235649672281 0.24422088911342 no 2588 0.228669511736262 3732 27243420
SGTC_944 3370-0224 231 µM -0.743758487561098 0.244067819230263 no 2589 0.228511299251758 3769 4580514
SGTC_2216 7189485 200 µM -0.745245247573202 0.243632827315943 no 2590 0.228061736947094 3740 731273
SGTC_983 1491-0821 12.2 µM -0.745746853599566 0.243486163388145 no 2591 0.227910175022452 3727 46495113
SGTC_3274 9138298 49.47 µM -0.74589661505054 0.243442384081552 no 2592 0.22786493509091 3720 17015756
SGTC_2708 st078559 56 µM -0.745957196103969 0.243424675815811 no 2593 0.22784663620485 3688 17250902
SGTC_1987 st072290 61.9 µM -0.747509631729466 0.242971125541637 no 2594 0.227377995505895 3766 54697379
SGTC_2272 7805186 180 µM -0.747860763968182 0.242868604282688 no 2595 0.227272072996007 3715 2956062 YPR165W RHO1
SGTC_2916 7875993 68.79 µM -0.748901516252089 0.242564869901961 no 2596 0.226958283187513 3716 1299250
SGTC_2065 5221596 34.26 µM -0.749827498934594 0.242294803045934 no 2597 0.226679302264948 3736 788581
SGTC_2121 5257820 149.641 µM -0.75130853889805 0.241863190298286 no 2598 0.226233495743545 3820 791256
SGTC_579 4491-1009 110 µM -0.752075072535908 0.241639966816173 no 2599 0.226002956810957 3892 1271041
SGTC_325 2810-4341 181 µM -0.753293736184428 0.241285308215915 no 2600 0.225636711007915 3744 774970
SGTC_3034 9090421 49.47 µM -0.754641195447065 0.240893496707297 no 2601 0.225232149398515 3682 17173761
SGTC_2279 7948423 32.93 µM -0.754807528836667 0.240845154627463 no 2602 0.225182237911336 3735 1247112
SGTC_2388 9080168 200 µM -0.756655844694427 0.240308327196059 no 2603 0.224628037502099 3738 15943073
SGTC_922 1866-0035 480 µM -0.756994674401793 0.240209987780546 no 2604 0.224526526532144 3742 3156169
SGTC_2957 9076800 11.52 µM -0.759272753902147 0.239549384683508 no 2605 0.223844706286841 3744 16459615
SGTC_3213 9129884 49.47 µM -0.760352543047385 0.239236611581893 no 2606 0.223521941165227 3760 17190742
SGTC_496 calpeptin 138 µM -0.760541983322837 0.239181761086527 no 2607 0.22346534194253 3745 73364 A calpain inhibitor.
SGTC_1031 k035-0009 16 µM -0.760579168445839 0.239170995321173 no 2608 0.223454233070911 3835 5180959
SGTC_1333 1482-0047 286 µM -0.760599330328465 0.239165158202377 no 2609 0.223448209939532 3741 3811116
SGTC_912 3474-0017 2.18 µM -0.761295143372716 0.238963759280944 no 2610 0.223240400372061 3795 3360550
SGTC_2982 9019404 25.97 µM -0.763486264472345 0.238330158603306 no 2611 0.222586725428452 3703 22333232
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.764747464101559 0.237965878494822 no 2612 0.222210968381903 3775 676296 Flavone; oxidizing agent.
SGTC_634 1611-4317 11.2 µM -0.764751557685441 0.237964696616807 no 2613 0.222209749344662 3783 2843522
SGTC_68 0986-0284 82.829 µM -0.765453149559593 0.237762184245671 no 2614 0.22200087715929 3848 423278 YIL048W NEO1
SGTC_1100 amiodarone 5.07 µM -0.766946116345236 0.237331558690411 no 2615 0.221556776591754 3855 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2256 7954252 200 µM -0.768984155937185 0.236744406476864 no 2616 0.220951358178533 3784 2972920
SGTC_688 0527-0193 473 µM -0.770290417002234 0.236368497673398 no 2617 0.22056381981445 3805 4007154
SGTC_1523 st012844 44.7 µM -0.770746958460452 0.236237194154833 no 2618 0.220428466100853 3901 4274103
SGTC_698 k064-0052 127 µM -0.771057764717774 0.236147827767539 no 2619 0.220336346661319 3848 5088751
SGTC_855 0428-0020 25 µM -0.771119744763209 0.236130008819726 no 2620 0.220317979120547 3803 6812414
SGTC_2891 9063876 19.48 µM -0.774708739486991 0.235099455278952 no 2621 0.219255892821987 3792 6472478
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.775648370620358 0.234830058012486 no 2622 0.218978315941131 3619 88881 An O-methylated flavonoid and antioxidant.
SGTC_2487 5918373 44.05 µM -0.77566538138514 0.234825182508316 no 2623 0.218973292646405 3805 2876279
SGTC_2772 vinpocetine 57.06 µM -0.776698082852035 0.234529301800742 no 2624 0.218668459111744 3789 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_981 1488-1094 54.9 µM -0.776961422120126 0.234453885119979 no 2625 0.218590765547392 3774 3449522
SGTC_1403 3909-7815 62.9 µM -0.777012257904116 0.234439328008202 no 2626 0.21857576918435 3746 6615483
SGTC_2468 5987765 72.9 µM -0.778309516182539 0.234068020086425 no 2627 0.218193283390924 3838 26772094
SGTC_3250 9135583 49.47 µM -0.779084653203721 0.233846311931733 no 2628 0.217964924905804 3832 7699353
SGTC_1393 3470-5649 58.2 µM -0.779300893184643 0.233784482772957 no 2629 0.21790124432954 3763 4108395
SGTC_2207 7258803 200 µM -0.779610727205326 0.233695908210916 no 2630 0.217810019918868 3749 3666799
SGTC_200 k038-0079 37.545 µM -0.780318733989475 0.233493574876849 no 2631 0.217601644230638 3759 3436683
SGTC_482 fipronil 114 µM -0.781510342055923 0.233153258033684 no 2632 0.217251198214125 3837 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_392 N-ethylmaleimide 8.33 µM -0.781579906831823 0.233133399218885 no 2633 0.217230749634547 3766 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_3118 9124250 49.47 µM -0.782514366306474 0.232866727997305 no 2634 0.216956172876375 3771 1504786
SGTC_1489 4065-0444 182 µM -0.784245263319528 0.232373221501724 no 2635 0.216448105276568 3758 2877968
SGTC_505 gw-5074 63.9 µM -0.784733773286798 0.232234044816656 no 2636 0.216304838360564 3852 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_3283 9109332 35.8195 µM -0.785386714212308 0.232048094139948 no 2637 0.216113433987657 3672 17027281
SGTC_1926 methyl fluorone black 53.6 µM -0.786110652985836 0.231842020963313 no 2638 0.215901331883224 3621 72721 Reacts with homocysteine.
SGTC_1803 st050068 52.4 µM -0.787557307574356 0.231430528277798 no 2639 0.215477847530129 3883 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.788814290178275 0.231073317615746 no 2640 0.215110278041967 3860 521171
SGTC_409 arachidonic acid 100 µM -0.78946480222055 0.23088857530741 no 2641 0.214920196973258 3818 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_573 3702-0553 84.7 µM -0.789735569120718 0.230811703118216 no 2642 0.214841107044576 3767 1222756
SGTC_2141 5621638 7.665 µM -0.790092398927021 0.230710419038341 no 2643 0.214736904312472 3855 2856238
SGTC_56 0957-0365 83.25 µM -0.790461013978585 0.230605815861851 no 2644 0.214629290855242 3803 6752360
SGTC_2453 5731132 22.18 µM -0.791003417392547 0.23045194435587 no 2645 0.214470998642201 3843 1362040
SGTC_3215 9129942 49.47 µM -0.792600301209534 0.229999266359894 no 2646 0.214005366592304 3762 17682944
SGTC_3107 9121808 49.47 µM -0.792982915107117 0.229890878508172 no 2647 0.213893888445606 3726 662681
SGTC_2200 6600604 21.907 µM -0.793040966789674 0.229874435976448 no 2648 0.213876977498164 3779 2904777
SGTC_2086 5274770 176.623 µM -0.794879214871904 0.229354112066095 no 2649 0.213341882996643 3875 689278
SGTC_1367 1812-0510 76.9 µM -0.795899563531566 0.229065583227181 no 2650 0.213045207486911 3869 1142582 YDR527W RBA50
SGTC_2384 9036245 200 µM -0.796634699985488 0.228857831459568 no 2651 0.212831609235757 3799 6462766
SGTC_3312 9133330 71.43 µM -0.797256764897641 0.228682116686428 no 2652 0.212650962270515 3883 17617324
SGTC_2896 9052656 71.43 µM -0.797774345882155 0.228535973260836 no 2653 0.212500725587561 3764 6469436
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.798107603202257 0.228441902972485 no 2654 0.212404024805463 3851 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3319 9138450 16.7555 µM -0.798142859384358 0.228431952298109 no 2655 0.212393796075571 3776 2029690
SGTC_444 curcumin 90.4 µM -0.798163731354179 0.228426061526147 no 2656 0.212387740713167 3778 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.798164754282973 0.228425772823427 no 2657 0.212387443944319 3855 23665772 A membrane-active detergent.
SGTC_1516 st013856 110 µM -0.799570787013391 0.228029139972819 no 2658 0.211979759305808 3896 5281404 A mutagen and neurotoxin.
SGTC_2427 5545055 42.75 µM -0.801956985942771 0.227356895860941 no 2659 0.211288920200426 3808 5372858
SGTC_1717 st033143 58.0435 µM -0.802386608902088 0.227235980455518 no 2660 0.211164678402143 3821 674616
SGTC_1480 1070-0044 41.2 µM -0.803357088813446 0.226962976789185 no 2661 0.210884184901767 3840 3124987
SGTC_2741 miltefosine 3.04 µM -0.80387403264951 0.226817631942756 no 2662 0.210734864146448 3784 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1000 4048-0884 8.67 µM -0.80542413400036 0.226382117646127 no 2663 0.210287484769226 3850 13040088
SGTC_313 3474-0040 5.03 µM -0.80559164663863 0.226335081823886 no 2664 0.210239171860494 3820 1043375 YIL048W NEO1
SGTC_1070 indatraline 8.81 µM -0.807017275955415 0.225935003274208 no 2665 0.209828264981908 3837 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2449 5812982 45.77 µM -0.812190374209135 0.224486624219158 no 2666 0.208341201005698 3821 776185
SGTC_2847 9005661 71.43 µM -0.812357045780909 0.224440046807238 no 2667 0.208293393033097 3822 2991449
SGTC_2154 5570129 200 µM -0.813319871811263 0.224171086436929 no 2668 0.208017343307339 3872 673366
SGTC_1866 st057638 64 µM -0.813361744550521 0.224159393662909 no 2669 0.208005342969142 3825 688802
SGTC_1216 1165-0504 9.65 µM -0.813413656314773 0.224144898017228 no 2670 0.207990466107036 3824 6304004
SGTC_2840 9008771 71.43 µM -0.814370789851272 0.223877727065574 no 2671 0.207716283564884 3816 2992978
SGTC_3075 9116269 49.47 µM -0.81978367649437 0.222370202813257 no 2672 0.20616971911875 3872 17015205 YNL244C SUI1
SGTC_2827 7993847 71.43 µM -0.821917553896726 0.221777499095314 no 2673 0.205561910829086 3920 2985692
SGTC_1122 capsaicin 818.572 nM -0.823453490749316 0.221351437920041 no 2674 0.205125077597151 3976 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3132 9126706 49.47 µM -0.828312883943187 0.220006553919387 no 2675 0.203746664087273 3932 850858
SGTC_350 k064-0020 19.8 µM -0.828637407954438 0.219916906073189 no 2676 0.203654806863166 3843 2790705
SGTC_1716 st033144 30.6155 µM -0.828649009436445 0.219913701620281 no 2677 0.203651523495798 3842 674617
SGTC_809 3998-0021 90 µM -0.830153089402325 0.219498485693558 no 2678 0.203226117048335 3833 715485
SGTC_2953 9074162 66.49 µM -0.830287542941493 0.219461390425178 no 2679 0.203188114725483 3816 16451992
SGTC_533 1222-0222 6.71 µM -0.830656838618344 0.219359521553285 no 2680 0.203083757794625 3952 3982874
SGTC_3178 9107506 49.47 µM -0.831846001533895 0.219031679960836 no 2681 0.202747937260322 3922 8897194
SGTC_2068 5226020 147 µM -0.833399270280792 0.218603882345672 no 2682 0.202309793065823 3925 1810509
SGTC_387 norethindrone acetate 66.7 µM -0.833961982099807 0.218449020359527 no 2683 0.202151203835879 3873 541197
SGTC_3324 9138759 60.749 µM -0.836194545119763 0.217835227319492 no 2684 0.20152273333477 3934 45595710
SGTC_3328 9140624 29.0385 µM -0.836853447086099 0.217654267313495 no 2685 0.201337475227803 3918 4904392
SGTC_790 1575-0012 79.1 µM -0.838838587220977 0.217109595561932 no 2686 0.200779946946313 3974 378741 YLR208W SEC13
SGTC_862 0452-0056 10.2 µM -0.838939627822245 0.217081893679612 no 2687 0.200751594411768 3854 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_281 1672-3440 14.9 µM -0.839031158515757 0.217056800852376 no 2688 0.200725912482944 3925 6833000
SGTC_1618 st003135 44.5 µM -0.839245186251515 0.216998132421234 no 2689 0.200665867701393 3800 1270615
SGTC_3278 9139605 49.47 µM -0.840088888943047 0.216766949286086 no 2690 0.200429274725751 3928 7958859
SGTC_553 k007-0256 45.7 µM -0.840524051148982 0.216647766101208 no 2691 0.200307311102346 3936 6287000
SGTC_170 4197-0004 226 µM -0.842317438432729 0.216156989395848 no 2692 0.199805146258145 3930 218692
SGTC_3186 9110464 49.47 µM -0.842665581620287 0.216061791530694 no 2693 0.199707750822582 3890 17018021
SGTC_2260 7964312 200 µM -0.842963333266971 0.215980392229044 no 2694 0.199624475429902 3948 231951
SGTC_3183 9108214 49.47 µM -0.84384635766626 0.215739095646247 no 2695 0.199377633437952 3833 4974831
SGTC_3293 9120939 62.045 µM -0.844306238295683 0.2156134898809 no 2696 0.199249150512402 3874 934087
SGTC_955 1216-0110 33 µM -0.845063438830127 0.215406770470537 no 2697 0.199037710073334 3852 3619719
SGTC_985 1493-0307 8.71 µM -0.845265729324115 0.215351563654784 no 2698 0.198981245431579 3918 3278274
SGTC_2638 epoxomicin 18 µM -0.845660990472112 0.215243717182655 no 2699 0.198870945423546 3900 9915668 A protesome inhibitor.
SGTC_3217 9129673 49.47 µM -0.846266380340638 0.215078598156226 no 2700 0.198702079196554 3892 17248312
SGTC_3306 9127676 59.7925 µM -0.847373153226475 0.214776917990959 no 2701 0.198393581818757 3904 41905287
SGTC_3064 1327-0027 10 µM -0.8494516493084 0.214211033906482 no 2702 0.197815011849547 3775 16000455 YPR107C YTH1
SGTC_1010 4112-3296 15.2 µM -0.849893393716752 0.214090877982682 no 2703 0.197692179400876 3979 704384
SGTC_1067 clotrimazole 1.36 µM -0.850964468122167 0.213799705141221 no 2704 0.197394545470098 3917 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.853241033119956 0.213181584864657 no 2705 0.19676282635019 3846 97141
SGTC_721 1187-1332 279 µM -0.853876904662215 0.213009122950044 no 2706 0.196586598709749 3847 25730
SGTC_2640 pentamidine 10.38 µM -0.854504298527899 0.212839040172312 no 2707 0.196412814355225 3919 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1784 st039334 36.3 µM -0.854714561834423 0.212782056769338 no 2708 0.196354593512495 3984 3496984
SGTC_1996 st072960 66.8 µM -0.856923700813745 0.212183897161229 no 2709 0.19574352667954 3893 1719405
SGTC_1921 5740136 50 µM -0.857253886707941 0.212094578582981 no 2710 0.195652293679242 3819 1774243
SGTC_3260 9137109 49.47 µM -0.859084119069374 0.211599881298003 no 2711 0.195147054154884 3818 17478346
SGTC_338 4055-0136 114 µM -0.861521130475164 0.210942226052234 no 2712 0.194475544204994 3859 2900563
SGTC_3208 9114115 49.47 µM -0.86217909786594 0.210764871741327 no 2713 0.194294485009538 3951 650895
SGTC_2254 7938975 95.19 µM -0.862556842079022 0.210663090780533 no 2714 0.194190583909133 3979 2969277
SGTC_1075 aripiprazole 15.2 µM -0.866566804648563 0.20958440900066 no 2715 0.19308970416078 3946 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1041 0206-0046 107 µM -0.866939239939377 0.209484388879977 no 2716 0.192987650947985 3949 50494
SGTC_2761 levamisole 97.89 µM -0.867353256153237 0.209373234875789 no 2717 0.192874242567081 3873 26879 An alkaline phosphatase inhibitor.
SGTC_1262 0737-0114 49.6 µM -0.868388168106439 0.209095536243962 no 2718 0.192590934947577 3978 765919
SGTC_695 3505-6186 243 µM -0.868694653935627 0.209013338336161 no 2719 0.192507083152644 3933 1819379
SGTC_2715 st079500 56.4 µM -0.868970354533133 0.208939413129847 no 2720 0.192431672994369 3869 28246688
SGTC_2531 methyl deoxycholate 70.07 µM -0.870000793195951 0.208663252002539 no 2721 0.192149985367395 3898 16667744 Haematoxylin.
SGTC_1670 st016595 4.04 µM -0.870065793149516 0.208645839006981 no 2722 0.192132225006524 3930 597879
SGTC_1135 dihydrocapsaicin 536.708 nM -0.870433881389243 0.208547247114507 no 2723 0.192031668807338 3851 107982 A Capsaicinoid.
SGTC_3091 9116372 49.47 µM -0.87068517224437 0.208479955009326 no 2724 0.191963038408048 4017 17169793
SGTC_1215 3852-0577 11.2 µM -0.870802615379108 0.208448509804633 no 2725 0.191930968496388 3997 2884876
SGTC_217 ketoconazole 989 nM -0.870944100668415 0.208410631067696 no 2726 0.191892337807368 3815 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_487 nimodipine 119 µM -0.871242317062214 0.208330805249716 no 2727 0.191810929351072 3835 4497 L-type voltage-gated calcium channels inhibitor
SGTC_933 2914-0560 114 µM -0.871898430666077 0.208155241908285 no 2728 0.191631894953112 3990 463887
SGTC_5 0352-0601 109.883 µM -0.871990134800143 0.208130710607685 no 2729 0.191606879706302 3857 762456
SGTC_1703 st026983 48.3 µM -0.875333416668113 0.20723753202676 no 2730 0.190696258413311 3936 1104023
SGTC_554 4483-2211 187 µM -0.875522698768326 0.207187032027914 no 2731 0.190644782560497 3976 747107
SGTC_3157 9099274 49.47 µM -0.876172732658493 0.207013660011731 no 2732 0.190468068782121 3915 17217662
SGTC_566 0958-0068 16.5 µM -0.877819876500759 0.206574731058338 no 2733 0.190020738036605 3844 6815365
SGTC_3202 9113761 49.47 µM -0.880072211433136 0.205975424565766 no 2734 0.189410095922591 3981 4798415
SGTC_555 4296-0685 37 µM -0.880138546408267 0.205957789649458 no 2735 0.189392129833993 3886 2908540 YHR072W ERG7
SGTC_1332 1480-0653 17.5 µM -0.880253016884295 0.205927360188284 no 2736 0.189361129248285 3938 5749438
SGTC_319 1348-1596 45.5 µM -0.88125614353624 0.205660815109316 no 2737 0.189089598823416 4041 5380505
SGTC_1231 0242-0792 125 µM -0.882162009646821 0.205420289594121 no 2738 0.188844601441209 3944 3707635
SGTC_2740 felodipine 17.08 µM -0.883503138008274 0.205064500181653 no 2739 0.188482243912441 3932 3333 L-type calcium channel blocker
SGTC_1883 5-benzylidenerhodanine 20 µM -0.885185921628285 0.204618591164516 no 2740 0.188028182056525 3952 1273210
SGTC_3049 9092223 49.47 µM -0.886110452524764 0.204373851948575 no 2741 0.187779005533424 3943 8623917
SGTC_1663 st014140 55.4 µM -0.886360892272257 0.204307586251396 no 2742 0.187711542958716 4022 4207120
SGTC_98 0074-0023 107.663 µM -0.886476671988699 0.204276955568122 no 2743 0.187680359688888 3956 3563821
SGTC_2685 mycophenolic acid 18.85 µM -0.886559212329533 0.204255120364136 no 2744 0.187658130825667 3922 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1752 st044819 83.042 µM -0.889985806105703 0.20334987697693 no 2745 0.186736753801105 3970 441209 YML126C ERG13
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.890096974500257 0.203320548469881 no 2746 0.186706908698837 3980 5282309
SGTC_1991 st073000 8.92 µM -0.894741046218609 0.202097603490156 no 2747 0.185462765691021 4056 4301969 YIL048W NEO1
SGTC_995 3931-2021 34.6 µM -0.896552360989285 0.201621817257477 no 2748 0.184978914121994 3966 730143
SGTC_637 1181-0519 7.26 µM -0.896945933432264 0.201518524614654 no 2749 0.184873884009049 3971 6252091 YGR060W ERG25
SGTC_1893 st059353 36.1 µM -0.898034628817606 0.201232962951639 no 2750 0.18458354407612 3980 3112488
SGTC_1922 5578187 25 µM -0.899459733132099 0.200859529074061 no 2751 0.184203917340212 3987 1350412
SGTC_583 1488-1091 88.9 µM -0.902609828240525 0.20003555605698 no 2752 0.183366504258302 4091 4303273
SGTC_624 k048-0052 28 µM -0.902762890019156 0.199995571395842 no 2753 0.183325875272132 3956 6835531
SGTC_767 0929-0023 86 µM -0.905476949168452 0.199287370164026 no 2754 0.182606383111597 4010 1204563
SGTC_274 sirtinol 40.1 µM -0.906654328214011 0.198980617459919 no 2755 0.182294811225726 4040 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_952 1185-0122 232 µM -0.908094520935395 0.198605778789882 no 2756 0.181914142505471 3919 678600
SGTC_2639 lactacystin 53 µM -0.908563932030513 0.198483697344014 no 2757 0.181790176250244 4029 3870 A proteasome inhibitor.
SGTC_3181 9108277 49.47 µM -0.90965266819997 0.198200720105581 no 2758 0.181502856607873 3908 17097298
SGTC_2134 5324836 1.464 µM -0.909916432249316 0.198132200932 no 2759 0.181433291546229 3952 699272
SGTC_3218 9131285 49.47 µM -0.910131239789935 0.198076409978558 no 2760 0.181376650595047 3934 17156417
SGTC_1121 fusaric acid 630.51 nM -0.912611822307556 0.19743282745933 no 2761 0.180723367158979 3963 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_3214 9129694 49.47 µM -0.913503403844244 0.197201817561007 no 2762 0.180488922104278 4011 17158655
SGTC_2319 6033012 152.6 µM -0.914971506585949 0.196821786821098 no 2763 0.180103294331857 3936 847246
SGTC_1319 1306-0155 43.7 µM -0.915170743491007 0.196770246869889 no 2764 0.180051000497253 4022 3122360
SGTC_2739 tacrine 100.86 µM -0.915242887786602 0.196751586110988 no 2765 0.18003206709025 4038 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2602 kawain 100 µM -0.915948874303465 0.196569033033091 no 2766 0.179846855353399 3979 5369129
SGTC_2470 5664817 21.68 µM -0.917767655767415 0.196099207841665 no 2767 0.179370259465668 4002 2859561
SGTC_2187 6125751 200 µM -0.918691232770154 0.195860891623351 no 2768 0.179128548420951 4000 874498
SGTC_758 0868-0029 16 µM -0.918987063863092 0.195784593696941 no 2769 0.179051169265456 4053 762687
SGTC_1472 k841-0093 193 µM -0.919823131604779 0.195569060651853 no 2770 0.178832596663018 4088 X1472
SGTC_1372 2752-0194 270 µM -0.920375918211094 0.195426634868525 no 2771 0.178688174320608 3952 823334
SGTC_943 3253-1379 105 µM -0.921292289051513 0.195190670232833 no 2772 0.17844892292379 4008 668464
SGTC_3124 9127567 49.47 µM -0.924447144317212 0.194379623039165 no 2773 0.177626779346824 4005 17592030
SGTC_1561 5-methoxyflavone 52.9 µM -0.924508867833204 0.194363775706932 no 2774 0.177610718303548 3917 94525
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.926027321904298 0.193974164811817 no 2775 0.177215890801012 3793 4000243
SGTC_3165 9101544 49.47 µM -0.926380321858853 0.193883658923626 no 2776 0.177124183441319 4011 5002184
SGTC_2143 5623677 140.463 µM -0.926525434994449 0.193846460738406 no 2777 0.177086492579147 3929 5375313
SGTC_2994 9053520 71.4286 µM -0.927843572997081 0.19350876955186 no 2778 0.176744358973663 4069 4647384
SGTC_1351 1496-0003 46.5 µM -0.930005172585009 0.192955770910231 no 2779 0.176184203166844 4039 3891978
SGTC_1376 2910-0861 41.3 µM -0.930090230842395 0.192934030343801 no 2780 0.176162184215533 3943 1112859
SGTC_3052 9092717 49.47 µM -0.93043967714062 0.192844728901319 no 2781 0.176071741658477 4033 25237534
SGTC_1091 telmisartan 47.6 µM -0.930542238411558 0.192818524032727 no 2782 0.17604520266401 4058 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_772 k072-0172 35.3 µM -0.931062088893394 0.192685733343589 no 2783 0.175910723890791 4049 5861980
SGTC_967 1306-0166 352 µM -0.932039918715436 0.192436107805682 no 2784 0.175657947953244 3975 4437607
SGTC_1860 st056228 74.6 µM -0.932829639838499 0.192234648045149 no 2785 0.175453967529142 3999 688679
SGTC_2926 9010726 65.15 µM -0.933786216628392 0.191990795849288 no 2786 0.175207090418451 4059 2994293
SGTC_228 caffeine 993.056 µM -0.933893459851259 0.191963469029782 no 2787 0.175179426405122 4011 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1515 3460-0031 42.1 µM -0.934402015711546 0.1918339155003 no 2788 0.175048279182373 3933 2876596
SGTC_1713 st033146 12.748 µM -0.93471717012442 0.191753657451501 no 2789 0.174967037912458 4001 674619
SGTC_2118 5526350 200 µM -0.934740065301251 0.191747827706967 no 2790 0.174961136870478 4060 743594
SGTC_3104 9120930 49.47 µM -0.934852219396555 0.191719271743873 no 2791 0.17493223190693 4041 17014836
SGTC_359 0081-0058 15.9 µM -0.936506471445376 0.191298379147253 no 2792 0.17450624109181 4094 3494159
SGTC_403 arphamenine a 50 µM -0.937696860259045 0.190995858317453 no 2793 0.174200108914572 3980 5487158 An arginine aminopeptidase inhibitor.
SGTC_589 1227-0070 34.1 µM -0.937731287401313 0.19098711350414 no 2794 0.174191260370823 4068 2841384
SGTC_378 3970-0959 8.33 µM -0.938820900023814 0.190710468694447 no 2795 0.173911353213634 4044 6615653
SGTC_420 mitomycin C 81.9 mM -0.939499870395211 0.190538207434768 no 2796 0.173737079376123 3999 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2184 6075246 200 µM -0.94080549140347 0.190207227506471 no 2797 0.173402273127627 4041 2267320
SGTC_2015 5119600 184 µM -0.940828645488924 0.190201361046636 no 2798 0.173396339330511 4071 2828786
SGTC_2103 5378138 10 µM -0.940903035287438 0.190182513947434 no 2799 0.173377276011506 4065 244142
SGTC_1087 pterostilbene 9.05 µM -0.941663579064151 0.189989891487318 no 2800 0.173182453683465 4083 5281727 Similar to reservatol, lowers cholesterol.
SGTC_3261 9137475 49.47 µM -0.944985782356195 0.189149885951466 no 2801 0.172333067311446 3942 17027690
SGTC_192 3455-0609 60.9 µM -0.945138669736329 0.189111284128366 no 2802 0.172294042730278 4092 3769639
SGTC_1511 0906-3109 28.5 µM -0.946635177725768 0.188733694002098 no 2803 0.171912356041069 4053 2882180
SGTC_2415 st077333 57.7 µM -0.946985409034834 0.188645392837079 no 2804 0.1718231070229 4067 2766255
SGTC_2098 5376439 882.5 nM -0.94858834703563 0.1882415813443 no 2805 0.171415009999863 4067 2844116
SGTC_1615 st002656 86.5 µM -0.948764505092373 0.188197236228026 no 2806 0.171370199179881 4019 1584458
SGTC_1141 3253-0389 52.6 µM -0.949146289609631 0.188101149899641 no 2807 0.171273107114927 4014 5402031
SGTC_1280 0880-0253 10.1 µM -0.951059433772966 0.187620111948796 no 2808 0.170787103017649 4024 6836607
SGTC_815 1582-0027 36.9 µM -0.954204699821473 0.186830924902047 no 2809 0.169990018067099 4088 3128206
SGTC_907 3448-6986 75.5 µM -0.954374238317715 0.186788443983775 no 2810 0.169947120835653 4069 590582
SGTC_1281 0884-0031 11.8 µM -0.95747284787631 0.186013085120404 no 2811 0.169164322364437 4051 1548255
SGTC_1426 4048-4480 71.7 µM -0.957695462997741 0.185957457517914 no 2812 0.169108172620168 4027 14224343
SGTC_2150 5556613 200 µM -0.959979112151523 0.18538740955636 no 2813 0.168532863828405 4036 743190
SGTC_225 nsc-122657 1.016 µM -0.960089934608331 0.18535977351493 no 2814 0.168504976908557 4049 275685
SGTC_278 4092-0821 23.9 µM -0.961125489177022 0.185101658607554 no 2815 0.16824453749604 4047 877900
SGTC_3084 9116877 49.47 µM -0.962641696336733 0.184724142672268 no 2816 0.167863682527607 3965 27241325
SGTC_681 1642-0006 26.6 µM -0.963642014086188 0.184475338780182 no 2817 0.167612717568279 4063 4446530
SGTC_3155 9099265 49.47 µM -0.964052263765052 0.18437335978789 no 2818 0.167509861896585 4078 25236499
SGTC_713 1488-1073 324 µM -0.964499163585445 0.18426231030294 no 2819 0.167397863775597 3974 3312542
SGTC_990 3985-0011 41.3 µM -0.966914392007322 0.183662874292072 no 2820 0.166793415678001 4043 5399565 YGL099W LSG1
SGTC_564 3555-0129 330 µM -0.967107945222776 0.183614888927226 no 2821 0.166745037025301 3895 563260
SGTC_2570 licareol 100 µM -0.968798618331792 0.183196072519517 no 2822 0.16632283805378 4061 443158
SGTC_3150 9097574 49.47 µM -0.969096226102231 0.183122410338086 no 2823 0.166248590240533 4098 17217476
SGTC_1157 4092-0394 27.6 µM -0.97146274060856 0.182537321924312 no 2824 0.165658949289304 4153 3659885
SGTC_1627 st003713 25.6 µM -0.9727134764319 0.182228566703397 no 2825 0.165347862750398 4102 16195070 YER133W GLC7
SGTC_1952 st077036 64.1 µM -0.973411439313226 0.182056410359193 no 2826 0.165174427884712 4078 2937007
SGTC_2608 thymoquinone 42.66 µM -0.974303140875383 0.181836615308412 no 2827 0.164953022805937 4050 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1998 st075797 76.8 µM -0.975079376098712 0.181645416687603 no 2828 0.16476044398334 4017 24208315
SGTC_2522 biochanin a 4.94 µM -0.976198956277718 0.181369868615313 no 2829 0.164482940183329 4072 5280373 A possible chelator.
SGTC_536 3852-0578 10.6 µM -0.976651683185163 0.181258519033397 no 2830 0.164370811479343 4121 2869208
SGTC_1711 st032263 62.8 µM -0.977323012074038 0.181093482448831 no 2831 0.164204631985654 4059 3958979
SGTC_345 1362-0200 395 µM -0.978495967420884 0.180805354204545 no 2832 0.163914542409183 4052 1419823
SGTC_465 cgp-37157 41 µM -0.97901396624345 0.180678202957786 no 2833 0.163786539397426 4004 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1320 1313-0481 95.3 µM -0.979177376460733 0.180638102895196 no 2834 0.16374617246241 4060 6813365 YLR208W SEC13
SGTC_2160 5660466 132.927 µM -0.983318215082632 0.179623824588199 no 2835 0.162725423989777 3950 2859134
SGTC_984 1492-0255 2.91 µM -0.983660544347384 0.179540133166558 no 2836 0.162641222819244 4049 1585198
SGTC_1125 tnp00248 1.32998 µM -0.984886346502505 0.179240654533144 no 2837 0.162339950344693 4168 24207736
SGTC_1753 st043925 64 µM -0.985327801243936 0.179132878667325 no 2838 0.162231540489826 4118 670181
SGTC_2528 xanthyletin 44.79 µM -0.988462911866428 0.178368652315634 no 2839 0.161462994832281 4121 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_224 benfluorex 43.875 µM -0.989124998815829 0.178207522615534 no 2840 0.161300993977095 4101 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2534 helenine 20.12 µM -0.991106187601224 0.177725916091949 no 2841 0.160816865964873 4073 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1048 3161-0300 24.5 µM -0.991722809965702 0.177576189281956 no 2842 0.160666380440234 4069 2165101
SGTC_1196 1588-0294 184 µM -0.993506179901927 0.177143603757423 no 2843 0.160231670165947 4090 6144269
SGTC_2303 7774051 200 µM -0.994109180447107 0.176997486835798 no 2844 0.160084858186772 4117 2953184
SGTC_3086 9117350 49.47 µM -0.994389795124587 0.1769295152708 no 2845 0.160016567191398 4023 2679265
SGTC_422 cantharidin 155 µM -0.99673569252334 0.176361928516691 no 2846 0.159446409958471 4012 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_939 1165-0479 45.3 µM -0.997811559000409 0.176102009805006 no 2847 0.159185372017284 4075 1377347
SGTC_2201 6605497 169.863 µM -0.998734437268238 0.175879244857372 no 2848 0.158961676838622 4011 670741
SGTC_2946 9065502 71.43 µM -0.9994003072698 0.175718627616748 no 2849 0.158800405526001 3890 16489101
SGTC_2743 auranofin 4.32 µM -1.00013513558962 0.175541484554145 no 2850 0.158622557284318 4046 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_3128 9127691 49.47 µM -1.00169232301148 0.175166471814229 no 2851 0.15824610780298 4146 41316314
SGTC_2717 st081029 62.2815 µM -1.00230761964968 0.175018431947346 no 2852 0.158097521792513 4057 5292846
SGTC_715 0868-0130 184 µM -1.00239720282099 0.174996884931523 no 2853 0.158075896279606 4141 2876258
SGTC_1979 st071809 45.3 µM -1.00286815493378 0.17488363673516 no 2854 0.157962239666157 4178 4976333
SGTC_794 k038-0031 316 µM -1.00349478324946 0.174733025761504 no 2855 0.157811096349469 4081 6624242
SGTC_2368 9071271 200 µM -1.01079634127537 0.172984159434436 no 2856 0.156056957310521 4119 27209959
SGTC_346 4513-0042 7.16 µM -1.01081201786592 0.172980416621693 no 2857 0.156053205016192 4084 2827372
SGTC_585 0kpi-0023 191 µM -1.01145082045347 0.172827945302598 no 2858 0.155900354020768 4050 64601
SGTC_521 r062-0005 13.8 µM -1.01297349355865 0.172464854642227 no 2859 0.155536410957838 4014 2832033
SGTC_2025 5147754 141 µM -1.0147255635439 0.172047665342051 no 2860 0.15511833244121 4080 315777 YLR208W SEC13
SGTC_782 0083-0095 30.5 µM -1.0160060053784 0.171743184247152 no 2861 0.154813263401304 4087 3591729 An indicator and reagent.
SGTC_2780 5215298 71.43 µM -1.0183560255179 0.171185260215767 no 2862 0.154254396109131 4153 2834131
SGTC_997 3996-0078 137 µM -1.01846294012116 0.171159904952492 no 2863 0.154229002108641 4148 735687
SGTC_1972 st070201 17.4 µM -1.01850320998869 0.171150355400905 no 2864 0.154219438060675 4106 2829099
SGTC_2915 7971052 15.16 µM -1.02213898781824 0.170289575372793 no 2865 0.153357561320656 4026 5741558
SGTC_2130 NSC 7 2.4545 µM -1.02365240811265 0.169932088036408 no 2866 0.152999740939906 4187 21448
SGTC_1060 3448-7350 82 µM -1.02468953460377 0.16968738482147 no 2867 0.152754851324801 4077 570178
SGTC_742 0kpi-0133 140 µM -1.02478857558203 0.169664028578301 no 2868 0.152731479059225 4152 2728852
SGTC_942 3253-1115 227 µM -1.02494269245842 0.169627688215832 no 2869 0.152695114380636 4177 46497897
SGTC_2239 6685329 187.64 µM -1.03098271347641 0.168207400225766 no 2870 0.151274463141787 4175 805680
SGTC_3237 9133362 49.47 µM -1.03154568542839 0.168075410400558 no 2871 0.151142497928635 4090 43845137
SGTC_3195 9113082 49.47 µM -1.03181406698453 0.168012511309746 no 2872 0.151079614072695 4103 17018038
SGTC_2963 9082507 9 µM -1.03470929555658 0.167334936111755 no 2873 0.150402346802988 4175 16459611
SGTC_2793 7325131 81.82 µM -1.03500005618473 0.167266986358458 no 2874 0.150334442479157 4094 4176441
SGTC_2092 5303694 80.6725 µM -1.03877546405161 0.166386301667611 no 2875 0.149454587499603 4132 1963699
SGTC_266 formosanin C 406 nM -1.03955510238701 0.166204810060689 no 2876 0.149273322623487 4015 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_360 0957-0399 1.01 µM -1.04150034907561 0.165752534868602 no 2877 0.14882169563789 4151 6752301 YPR165W RHO1
SGTC_97 0535-0701 19.132 µM -1.04248064219458 0.165524915839922 no 2878 0.148594447849338 4039 2832013 YGL099W LSG1
SGTC_1248 0469-0687 58.6 µM -1.04248435787381 0.165524053463082 no 2879 0.148593586936419 4128 4017482
SGTC_2572 astragaloside iv 100 µM -1.04339289877307 0.1653132762519 no 2880 0.148383180539532 4179 45006101 An anti-inflammatory agent.
SGTC_921 1561-0023 372 µM -1.04484577942195 0.164976575885309 no 2881 0.148047126359648 4107 24050882
SGTC_1056 3448-1962 115 µM -1.04599682735872 0.164710139751711 no 2882 0.14778124859363 4154 715507
SGTC_1808 st050063 61.5 µM -1.04632106010518 0.164635139084515 no 2883 0.147706412611741 4132 4011993
SGTC_3114 9122766 49.47 µM -1.04684177470875 0.164514735064794 no 2884 0.147586279878474 4141 17176985
SGTC_157 1348-1695 65.819 µM -1.04774918450447 0.16430505254043 no 2885 0.147377090131186 4087 5380510
SGTC_852 0418-0143 439 µM -1.04857231925997 0.164114994088843 no 2886 0.147187500687237 4153 5369229
SGTC_2438 5259590 200 µM -1.04870796362459 0.16408368805065 no 2887 0.147156273943819 4152 1201127
SGTC_2614 arthonioic acid 13.39 µM -1.04937985599733 0.163928675786263 no 2888 0.147001662821764 4001 6710684
SGTC_2980 9014342 25.29 µM -1.05077146825588 0.163607919297327 no 2889 0.146681781429094 4207 2996599
SGTC_2372 9071633 200 µM -1.05399584809517 0.162866290303092 no 2890 0.14594240900989 4173 21321366
SGTC_2648 atorvastatin 78.68 µM -1.0563044117867 0.162336650131184 no 2891 0.145414580507333 4150 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_627 1391-0720 175 µM -1.05898790342365 0.161722403129888 no 2892 0.144802644398228 4133 997839
SGTC_3315 9136395 68.55 µM -1.05944326148267 0.161618322908607 no 2893 0.1446989781388 4158 16876844
SGTC_191 3914-0123 66.505 µM -1.0602604072956 0.161431659138542 no 2894 0.144513073087343 4151 3144412
SGTC_2031 5180455 200 µM -1.06585873655706 0.160156593797285 no 2895 0.143243752207695 4113 29949
SGTC_3309 9129340 25.759 µM -1.06788266889811 0.159697251442552 no 2896 0.142786720603757 4184 17158987
SGTC_714 4296-0578 26.1 µM -1.06973720468664 0.159277112139132 no 2897 0.142368807367733 4198 1589775
SGTC_401 neomycin 50 µM -1.07258504484777 0.158633353341521 no 2898 0.141728668850092 4126 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1104 tacrolimus 29.8 µM -1.07553786406493 0.157967667964132 no 2899 0.141066994723763 4223 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2439 5492030 7.2 µM -1.07622445054598 0.157813146677305 no 2900 0.140913443605638 4168 5722370
SGTC_649 1123-0311 367 µM -1.07727574757792 0.157576737062173 no 2901 0.140678546860411 4062 693629 YIL048W NEO1
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.07786423753844 0.157444502473181 no 2902 0.140547173573188 4171 5024745
SGTC_1673 st016611 27.3 µM -1.0779832251806 0.157417774635547 no 2903 0.140520621141782 4196 5226799
SGTC_2750 bromebric acid 70.15 µM -1.07819807365419 0.157369521420926 no 2904 0.140472685718896 4212 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_543 3844-1095 191 µM -1.0818234086152 0.156556767084271 no 2905 0.139665501495894 4174 4230703
SGTC_2684 capsaicin 100 µM -1.08304216935802 0.156284158110088 no 2906 0.139394852992655 4187 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2988 9073640 71.4286 µM -1.08475480218214 0.155901609958661 no 2907 0.139015134316329 4245 9102229
SGTC_2629 bisabolol 100 µM -1.08514185184886 0.155815240860253 no 2908 0.138929416726422 4217 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_495 decylubiquinone 155 µM -1.08617126046313 0.155585684639484 no 2909 0.138701614881204 4241 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1088 bifonazole 369 nM -1.08658781970287 0.155492856130858 no 2910 0.138609505214243 4132 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.08734498537623 0.155324218473066 no 2911 0.138442187317595 4150 688803
SGTC_2240 6690706 185.951 µM -1.08780590898566 0.155221619645664 no 2912 0.138340400193393 4045 805876
SGTC_2890 9046729 58.44 µM -1.09231908888358 0.154219376863848 no 2913 0.137346436418773 4139 903329
SGTC_3246 9135460 32.98 µM -1.09305730532717 0.154055849190179 no 2914 0.137184319987482 4155 41446951
SGTC_2517 totarol 10 µM -1.0969175565744 0.153202605926594 no 2915 0.136338716631184 4201 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1988 st071872 53.4 µM -1.09831280820442 0.152894981124376 no 2916 0.136033960466437 4221 16414116
SGTC_1330 1469-0054 61.8 µM -1.09855118768284 0.152842464259019 no 2917 0.135981939393189 4186 7102664
SGTC_252 miconazole 1.30953 nM -1.09984187285351 0.152558323956919 no 2918 0.135700512285493 4094 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_254 nsc-64875 3.808 µM -1.10224950120325 0.152029229351902 no 2919 0.135176608438007 4198 56993
SGTC_528 3492-0019 172 µM -1.10310071988794 0.151842459550629 no 2920 0.134991714131999 4191 2869262
SGTC_1779 st039427 55 µM -1.10404973778748 0.1516344109786 no 2921 0.134785781313453 4169 1124498
SGTC_299 1273-0059 1.44 µM -1.10454286599467 0.151526379725783 no 2922 0.134678859751134 4034 2848077
SGTC_2362 9071156 126 µM -1.10597858212613 0.151212143991277 no 2923 0.134367894895381 4220 653133
SGTC_2870 9038528 12.99 µM -1.10953372878917 0.150435894685458 no 2924 0.133600001179157 4244 6463316
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.11088378852885 0.150141812314809 no 2925 0.133309187186407 4191 756377
SGTC_2251 lansoprazole 556 µM -1.11141810961238 0.150025527524693 no 2926 0.133194210406736 4122 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_197 4544-0043 41.561 µM -1.11263692600698 0.149760500153969 no 2927 0.132932197338914 4202 896523
SGTC_2433 5607874 27.82 µM -1.11392913742682 0.1494798545861 no 2928 0.132654794085043 4171 2252428
SGTC_930 2810-3379 265 µM -1.11448472014133 0.149359299776144 no 2929 0.132535647990085 4246 1015764
SGTC_3308 9128332 17.569 µM -1.11628289803312 0.148969561775295 no 2930 0.132150529856488 4213 17332805 YDL196W YDL196W
SGTC_206 4546-0025 72.014 µM -1.11681799412236 0.14885371606722 no 2931 0.13203607673072 4257 6620745 YIL048W NEO1
SGTC_2645 abamectin 100 µM -1.11805995863532 0.148585068843296 no 2932 0.131770693153826 4166 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2281 7943571 200 µM -1.1185965482065 0.148469100412793 no 2933 0.131656148363153 4331 1244024
SGTC_2965 9082772 38.63 µM -1.12002832912284 0.148159958371235 no 2934 0.131350845076455 4231 16459634
SGTC_174 3553-0389 74.3 µM -1.12283721006267 0.147554732825697 no 2935 0.13075331939519 4293 738071
SGTC_571 k831-0106 44.2 µM -1.12546046553946 0.146991001404379 no 2936 0.130196980511585 4082 4783639
SGTC_3040 9091894 49.47 µM -1.12546136538463 0.14699080827791 no 2937 0.130196789954264 4063 25236966
SGTC_3326 9140064 16.379 µM -1.12652591479243 0.146762451851291 no 2938 0.12997148889747 4135 1868434
SGTC_2948 9070189 9.45 µM -1.12662110404697 0.146742044409323 no 2939 0.129951356212872 4173 6473636 YDL196W YDL196W
SGTC_117 lucigenin 22.078 µM -1.12710090769541 0.146639209209438 no 2940 0.129849909814863 4216 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_832 4083-0019 164 µM -1.12768193005863 0.146514744792961 no 2941 0.129727135846165 4296 1990758
SGTC_953 1188-0045 9.7 µM -1.13027972032502 0.145959123445723 no 2942 0.12917918852269 4237 6144426
SGTC_1385 3091-4834 14.1 µM -1.13136158943035 0.145728148926171 no 2943 0.128951465681431 4191 4072814
SGTC_1809 st050081 57.6 µM -1.13175638306382 0.145643923364089 no 2944 0.128868434868387 4303 5036894
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.13642756077312 0.144649855569968 no 2945 0.127888833294641 4225 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3176 9106582 49.47 µM -1.14332101496961 0.143191234618675 no 2946 0.126452666440582 4198 17018027
SGTC_1788 fluconazole 20 µM -1.14403688246754 0.143040332025966 no 2947 0.126304170771174 4270 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2333 9017922 200 µM -1.14410247979651 0.143026509693572 no 2948 0.126290569697619 4271 3163164
SGTC_3173 9105693 49.47 µM -1.14606912477635 0.14261252745985 no 2949 0.125883275778986 4243 17096658
SGTC_3083 9117465 49.47 µM -1.14911628322226 0.14197269696127 no 2950 0.125254017456135 4236 16420915
SGTC_393 acivicin 6.25 µM -1.14963135821066 0.141864735832056 no 2951 0.125147868444287 4101 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_562 3772-2733 112 µM -1.15496724151535 0.14074959113852 no 2952 0.124051920757484 4225 2876874 YIL048W NEO1
SGTC_256 clotrimazole 625 nM -1.15547562612346 0.140643655199254 no 2953 0.12394785411849 4179 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_891 0929-0073 133 µM -1.15627360694351 0.140477483069488 no 2954 0.123784630202918 4281 5603632
SGTC_1719 st032227 49.2 µM -1.15727025382807 0.140270127839032 no 2955 0.123580981317598 4248 3125804
SGTC_1797 st048695 56.8 µM -1.15861317012072 0.139991059177067 no 2956 0.123306949052799 4217 592262 YIL048W NEO1
SGTC_1768 st044301 37.178 µM -1.15934045279701 0.139840081660641 no 2957 0.123158719355818 4257 3931349
SGTC_847 0342-0274 5.54 µM -1.1604522676982 0.139609492612669 no 2958 0.122932358438098 4256 18097
SGTC_998 3996-0085 177 µM -1.16072373181139 0.139553230583294 no 2959 0.122877133801653 4289 715391
SGTC_3042 9091578 49.47 µM -1.16106311976527 0.139482912757296 no 2960 0.12280811571779 4233 25236497
SGTC_1494 4358-1428 177 µM -1.16563512016322 0.138537988478098 no 2961 0.121881001009734 4282 1564571
SGTC_703 3875-0075 71.8 µM -1.1670973382864 0.138236705293702 no 2962 0.121585531327672 4312 2850814
SGTC_1829 berberine 14.4 µM -1.16827376704617 0.137994632163423 no 2963 0.121348176694209 4220 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.17205251895554 0.13721903705247 no 2964 0.120587985595557 4215 688761
SGTC_61 0978-8327 98.565 µM -1.17361092480166 0.136900040525155 no 2965 0.120275451657482 4176 6150059 YHR072W ERG7
SGTC_2886 9058944 51.95 µM -1.17445611488097 0.136727247220684 no 2966 0.120106190019215 4140 4949929
SGTC_1846 st056244 14.8 µM -1.17508133193515 0.136599521875489 no 2967 0.119981089249235 4279 5393182
SGTC_1019 4262-0212 3.4 µM -1.17819468139158 0.135964711891529 no 2968 0.119359501218075 4283 4677213
SGTC_859 0439-0102 54.6 µM -1.1793141624573 0.135736944892267 no 2969 0.119136550441049 4276 610143
SGTC_2032 5185112 25.99 µM -1.18076851867896 0.135441435466616 no 2970 0.118847346724595 4151 5718189
SGTC_3264 9137442 49.47 µM -1.18084308884112 0.135426295509281 no 2971 0.118832531568015 4251 17015726
SGTC_2848 9016370 25.97 µM -1.18132093101344 0.135329306887074 no 2972 0.118737627686299 4269 7894410
SGTC_3061 glucosamine 200 µM -1.18262357702932 0.135065147963097 no 2973 0.118479182103107 4195 91431 and experimental redox chemotherapeutic
SGTC_833 3852-0053 558 µM -1.18345232629297 0.134897273030562 no 2974 0.118314964937288 4330 3123681
SGTC_39 0986-0283 58.349 µM -1.19280480286125 0.133012716645176 no 2975 0.116472914340397 4357 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2166 5933061 31.504 µM -1.19369704701293 0.132833878031314 no 2976 0.116298248021659 4401 2877375
SGTC_298 1391-0729 10 µM -1.19483556487727 0.13260591762302 no 2977 0.116075640982329 4211 3237558
SGTC_85 0868-0259 160.055 µM -1.1955084956061 0.13247130646579 no 2978 0.115944209485481 4182 83173
SGTC_1699 st031318 29.054 µM -1.19627942099127 0.132317208495569 no 2979 0.115793768348709 4328 5340658
SGTC_2203 7227154 166.4 µM -1.19714640110726 0.132144058089409 no 2980 0.115624748420421 4296 896304
SGTC_490 phenamil 164 µM -1.19804850368407 0.131964059055982 no 2981 0.115449067413891 4265 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1902 st060212 70.5 µM -1.19935551150746 0.131703568266389 no 2982 0.11519486929827 4285 688944
SGTC_201 4262-0159 12.803 µM -1.19967661672662 0.131639625312043 no 2983 0.115132478928702 4320 1341029
SGTC_2663 amphotericin b 100 µM -1.19970220603026 0.131634530534504 no 2984 0.115127507990663 4292 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_57 miconazole 162.5 nM -1.20015212160252 0.131544975501897 no 2985 0.11504013302398 4143 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3151 9099821 49.47 µM -1.20165861633212 0.131245416142908 no 2986 0.114747910518802 4235 17174189
SGTC_500 h-89 112 µM -1.20435980964053 0.130709477028602 no 2987 0.114225269447705 4283 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_150 3970-0969 77.2 µM -1.20594524389138 0.130395619282637 no 2988 0.113919301964619 4364 6615640
SGTC_3105 9121040 49.47 µM -1.20622674741307 0.130339946466585 no 2989 0.113865036679191 4193 41448907
SGTC_1888 azatryptophan 97.5 µM -1.20632647744179 0.130320226851952 no 2990 0.113845816193824 4343 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1825 st052143 62.6 µM -1.20905840040581 0.129780846354481 no 2991 0.113320204813756 4333 674173
SGTC_1431 4049-0260 9.09 µM -1.21101427512929 0.129395636707426 no 2992 0.112944966858278 4302 3854841
SGTC_2499 avocadenofuran 51.48 µM -1.21134742870136 0.129330101145342 no 2993 0.112881139270833 4249 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1744 st037937 38.9 µM -1.21227243385885 0.129148261434154 no 2994 0.112704056165881 4346 1016152
SGTC_1442 4112-3290 3 µM -1.21512100051209 0.128589397132374 no 2995 0.112159972526368 4293 704353
SGTC_3207 9114163 49.47 µM -1.21543289429599 0.128528308347799 no 2996 0.112100514231932 4319 849233
SGTC_913 3487-1245 167 µM -1.21687623139323 0.128245872775554 no 2997 0.11182565510846 4250 4016153
SGTC_800 3448-7362 155 µM -1.21733919528565 0.128155370281014 no 2998 0.111737593651694 4370 15991913
SGTC_1306 1185-0270 9.02 µM -1.2220911096901 0.127229006228514 no 2999 0.110836587353868 4330 1548076
SGTC_2955 9076254 12.21 µM -1.22653796427855 0.1263663411646 no 3000 0.109998148943561 4213 16459619
SGTC_2036 5160441 105 µM -1.22735193069687 0.126208878543703 no 3001 0.109845172546995 4294 134534 YIL048W NEO1
SGTC_864 0469-0573 172 µM -1.22790945773154 0.126101103327426 no 3002 0.109740479374297 4274 689425
SGTC_2437 5741531 144.16 µM -1.22965106907223 0.125764846804267 no 3003 0.109413898674353 4329 2262990
SGTC_129 0088-0017 176.636 µM -1.2306571678001 0.125570882502509 no 3004 0.109225557062968 4191 182446
SGTC_865 0488-0499 301 µM -1.2314948299317 0.125409550172057 no 3005 0.109068924568894 4263 9634651
SGTC_493 zm226600 134 µM -1.23159345114193 0.125390565415331 no 3006 0.109050494245212 4334 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1270 0831-1170 17.3 µM -1.23400432986972 0.124927090859912 no 3007 0.108600645404037 4315 6764716
SGTC_1435 4092-0789 56.7 µM -1.23774790819865 0.124209788543074 no 3008 0.107904774549432 4302 2248285
SGTC_2971 9092186 9.93 µM -1.24218241233724 0.123363832736411 no 3009 0.107084633620565 4297 25236400
SGTC_3230 9131665 49.47 µM -1.24296496177784 0.123214968353052 no 3010 0.106940372657913 4299 15943720
SGTC_2297 7971671 152.32 µM -1.24329599222114 0.12315203433466 no 3011 0.106879390268599 4327 909016
SGTC_2605 digitonin 300 nM -1.24370703281451 0.123073920505922 no 3012 0.106803703342274 4335 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_963 1269-2853 151 µM -1.24436946319422 0.122948105860329 no 3013 0.106681808178661 4303 3668223
SGTC_2735 sertaconazole 140 nM -1.244726452685 0.122880340659171 no 3014 0.106616159465197 4463 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1948 st076329 66.6 µM -1.24740875344019 0.122372013021368 no 3015 0.106123829283343 4243 24208413
SGTC_414 piperonyl butoxide 100 µM -1.2488493586296 0.122099611355442 no 3016 0.105860088426161 4325 5794 A potent inhibitor of cytochrome P450.
SGTC_497 capsazepine 133 µM -1.2506665404791 0.121756611098047 no 3017 0.105528081369552 4272 2733484 A calcium channel blocker.
SGTC_1754 st042065 16.137 µM -1.25148256656548 0.121602803427292 no 3018 0.105379235098371 4098 1126236 YIL048W NEO1
SGTC_1773 st048542 73.5835 µM -1.25222484067696 0.121463015452335 no 3019 0.105243973424185 4292 3237138
SGTC_2183 6420625 130.508 µM -1.25365372738838 0.121194240024186 no 3020 0.104983946810241 4343 2897619
SGTC_1925 st057770 10.1 µM -1.25560714097224 0.120827477657751 no 3021 0.10462922052243 4321 5989122
SGTC_1287 0971-0001 34.6 µM -1.25721859936644 0.120525507503017 no 3022 0.104337245061129 4327 4665869
SGTC_2551 apiole 73.87 µM -1.25935013148221 0.12012689800699 no 3023 0.103951946657518 4236 10659 A possible DNA adduct former.
SGTC_167 3672-0051 66.205 µM -1.25993529227679 0.12001763207976 no 3024 0.103846353004405 4247 3237971
SGTC_890 0929-0006 47.2 µM -1.26095657489863 0.119827097836621 no 3025 0.103662246557644 4330 1378169
SGTC_2199 6590217 200 µM -1.26220935137914 0.119593666640361 no 3026 0.103436732325524 4235 703109
SGTC_596 1155-0152 116 µM -1.26364485432589 0.119326582388862 no 3027 0.103178763270322 4354 280313
SGTC_1145 3546-0597 10.2 µM -1.26532298398479 0.119014889925552 no 3028 0.102877785352267 4298 875334
SGTC_2644 guaiazulene 100 µM -1.26545250291243 0.118990857256974 no 3029 0.102854582263033 4350 3515 A coloring agent.
SGTC_3048 9093155 49.47 µM -1.26726571838603 0.118654768834719 no 3030 0.102530147037255 4306 25236002
SGTC_2642 cholecalciferol 100 µM -1.26731636006738 0.118645391787165 no 3031 0.102521096508726 4323 9821465 A vitamin D precursor, similar to steriods.
SGTC_2104 5389443 200 µM -1.26828484883795 0.118466162684349 no 3032 0.102348122872294 4363 2244536
SGTC_2323 6148992 148.28 µM -1.26875775844894 0.118378715321776 no 3033 0.102263737624552 4306 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2457 5731572 11.68 µM -1.26997632480015 0.118153596278755 no 3034 0.102046531782195 4391 2865357
SGTC_2073 5212005 126 µM -1.27034957317647 0.118084702645827 no 3035 0.101980068569759 4222 691789
SGTC_449 xestospongin c 11.1929 µM -1.2715341242645 0.117866248139448 no 3036 0.101769347763439 4348 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1345 1488-0192 31.4 µM -1.27167304546092 0.117840647086178 no 3037 0.101744655734689 4388 658348
SGTC_2144 5628481 200 µM -1.27324009137867 0.117552136963115 no 3038 0.101466429043932 4327 2818399
SGTC_2458 5808907 16.39 µM -1.27383835434703 0.117442122280565 no 3039 0.101360354636613 4485 2731747
SGTC_1428 4049-0204 61.7 µM -1.27835465595444 0.116613970953319 no 3040 0.100562202229883 4380 X1428
SGTC_511 blebbistatin 171 µM -1.28487359997806 0.115425912534991 no 3041 0.0994182288523784 4409 3476986 A myosin inhibitor.
SGTC_1283 0922-0125 16.4 µM -1.28516830244144 0.115372407834222 no 3042 0.0993667388173021 4342 3360884
SGTC_3065 9113888 49.47 µM -1.28668522071591 0.115097282631625 no 3043 0.0991020132177406 4396 16648368
SGTC_3111 9122088 49.47 µM -1.28795901623271 0.114866613488258 no 3044 0.0988801150192686 4238 16876704
SGTC_2215 7188065 200 µM -1.28938486296508 0.114608799978017 no 3045 0.0986321605957362 4403 940217
SGTC_2497 7-hydroxyflavone 100 µM -1.2899466982341 0.114507325303327 no 3046 0.098534582674206 4357 5281894
SGTC_574 1315-0397 40 µM -1.29382452417832 0.113808683843011 no 3047 0.0978630198150466 4342 6794277
SGTC_1365 1672-3266 55.4 µM -1.2957619487473 0.113460771575791 no 3048 0.0975287556350743 4388 6415873
SGTC_2786 7743617 45.45 µM -1.29979302563893 0.112739324766959 no 3049 0.0968359582623819 4303 583674
SGTC_1303 1160-0052 261 µM -1.30197748602885 0.112349740467815 no 3050 0.0964620410199844 4311 3562476
SGTC_466 geldanamycin 89.2 µM -1.30267896123107 0.112224841214954 no 3051 0.0963421938162411 4365 5288382 HSP90 inhibitor.
SGTC_1941 st076221 61.8 µM -1.30293540121161 0.112179206273181 no 3052 0.0962984083108172 4247 2828568
SGTC_323 4013-0906 34.3 µM -1.30301510953734 0.112165024429202 no 3053 0.096284801598107 4385 2910086
SGTC_327 1273-0057 3.96 µM -1.30359244911578 0.112062341422968 no 3054 0.0961862882824423 4270 3108138
SGTC_124 0136-0217 7.121 µM -1.30450441381973 0.111900280451138 no 3055 0.0960308277913474 4429 3976905
SGTC_294 k038-0071 157 µM -1.30480261424863 0.11184732502954 no 3056 0.0959800343664937 4375 24152826
SGTC_641 4092-0595 30 µM -1.3069361007883 0.11146897618164 no 3057 0.0956172070515475 4419 786260
SGTC_2935 9038016 29.96 µM -1.30760984348898 0.111349686315988 no 3058 0.0955028382352862 4334 6463195
SGTC_2419 paclitaxel 166.5 µM -1.3101770609495 0.110895983805883 no 3059 0.0950679719824037 4320 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2267 7931562 200 µM -1.31124782565374 0.110707140226609 no 3060 0.0948870245979026 4315 934880
SGTC_2775 cyproheptadine 69.59 µM -1.31635092502002 0.109810307053516 no 3061 0.0940281428858009 4384 2913 A selective serotonin reuptake inhibitor.
SGTC_1757 st041620 31.8375 µM -1.31768904296982 0.109576007757625 no 3062 0.093803881988746 4415 5289815
SGTC_2729 fluphenazine 10.66 µM -1.32012238849776 0.109150858675887 no 3063 0.0933970794700315 4315 3372 An atypical antipsychotic.
SGTC_2689 tacrolimus 100 µM -1.32373511578286 0.108521838864667 no 3064 0.0927955158449588 4386 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_285 1486-1325 46 µM -1.32764761277635 0.107843571442138 no 3065 0.0921472737566426 4429 22310230
SGTC_1545 lovastatin 49.4 µM -1.33008612628891 0.107422380194215 no 3066 0.0917449480425741 4423 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1451 4152-0210 104 µM -1.33045455700185 0.107358846396633 no 3067 0.0916842746930338 4424 659563
SGTC_1182 1222-0449 220 µM -1.33264607716835 0.106981490827658 no 3068 0.0913239883113129 4379 658318
SGTC_1044 1222-0021 1.78 µM -1.33534835750623 0.106517506431338 no 3069 0.0908811792425226 4317 4306703
SGTC_1849 st056239 19.2 µM -1.33929663167721 0.105842198263929 no 3070 0.0902370624301568 4380 5393181
SGTC_275 trichlorophene 5.69 µM -1.34330100875705 0.105160460682079 no 3071 0.0895872628027031 4435 62616
SGTC_696 1560-0013 611 µM -1.34542804571384 0.104799631583839 no 3072 0.0892435216819649 4433 1650269
SGTC_1364 1653-0028 37.6 µM -1.35400756391006 0.103353309264424 no 3073 0.0878669822821485 4393 5718652
SGTC_2064 5220758 200 µM -1.35840036552732 0.102618411150403 no 3074 0.0871683391797116 4443 788518
SGTC_1299 1079-1439 3.74 µM -1.36398389796205 0.101689800619206 no 3075 0.0862863167618427 4390 323161
SGTC_292 k038-0015 474 µM -1.36599183133219 0.101357356669739 no 3076 0.08597076366107 4407 46368540
SGTC_1061 3448-9325 110 µM -1.36792741441745 0.101037641562649 no 3077 0.0856673988151109 4368 723482
SGTC_704 1310-0270 142 µM -1.3685476754453 0.100935343980085 no 3078 0.0855703547753913 4407 5718033
SGTC_988 1497-1057 103 µM -1.37328536894411 0.100156462176044 no 3079 0.0848318246258816 4406 3533044
SGTC_2 0422-0095 29 µM -1.37445277901761 0.099965214312624 no 3080 0.0846505802320425 4314 6790840
SGTC_749 1000-0129 128 µM -1.37812419623409 0.0993654925296615 no 3081 0.0840824731092279 4457 708470
SGTC_1970 st070122 35.8 µM -1.3789781968251 0.0992263703561088 no 3082 0.0839507381948144 4426 102928
SGTC_172 1112-0046 2.638 µM -1.38151328731746 0.0988142269016032 no 3083 0.0835605976024218 4394 2802135 YIL048W NEO1
SGTC_1441 4106-0040 13 µM -1.38334366784547 0.0985174316695173 no 3084 0.0832797572100769 4447 2904180
SGTC_2258 7960471 200 µM -1.38346076925538 0.0984984659748896 no 3085 0.083261814194606 4420 2974708
SGTC_1331 1472-0049 76.2 µM -1.38386788573527 0.0984325503646933 no 3086 0.0831994558608933 4399 24051409
SGTC_3266 9136860 49.47 µM -1.38631081544405 0.0980376976446504 no 3087 0.0828260078729741 4199 4871271 YPR165W RHO1
SGTC_430 0958-0115 16.4 µM -1.38967015456114 0.0974966220019517 no 3088 0.0823145308561443 4355 6833180
SGTC_1912 st060209 90.8 µM -1.39072314120137 0.0973274732433052 no 3089 0.0821546987424866 4406 688787
SGTC_1726 st035556 14.5795 µM -1.39154661329947 0.0971953431390029 no 3090 0.0820298674660733 4468 5919439
SGTC_1848 st056003 16.4 µM -1.39294351777458 0.0969715041405727 no 3091 0.081818435693072 4437 146492
SGTC_3314 9135860 59.4275 µM -1.39295034732427 0.0969704107086852 no 3092 0.081817403000407 4418 25252478
SGTC_1614 st002383 48.6 µM -1.3940350359718 0.0967968635779146 no 3093 0.0816535124489089 4455 1947235
SGTC_2394 5221648 200 µM -1.39693491362759 0.0963340114868191 no 3094 0.0812165721942498 4452 788586
SGTC_2571 chrysanthemic acid 100 µM -1.39837848888138 0.0961042084433189 no 3095 0.0809997196608569 4412 2743 An insecticide.
SGTC_1421 4029-0249 71.4 µM -1.40027675487607 0.0958026368830325 no 3096 0.0807152294547468 4515 2894095
SGTC_63 0099-0242 26.702 µM -1.40825132983625 0.0945433445280512 no 3097 0.0795283309068793 4453 3898502 YLR359W ADE13
SGTC_2879 9041815 71.43 µM -1.40827971458086 0.094538884096981 no 3098 0.0795241299706352 4477 4942971
SGTC_2074 5212007 75.395 µM -1.40887283683308 0.0944457152610817 no 3099 0.0794363864118397 4360 758611
SGTC_822 1487-0950 154 µM -1.40986073295601 0.0942906848714415 no 3100 0.0792904046502609 4446 1958375
SGTC_3200 9114385 49.47 µM -1.41408175381281 0.0936303946687682 no 3101 0.0786689499035025 4427 17018030 YLR208W SEC13
SGTC_3313 9133968 57.047 µM -1.41801025496822 0.0930189363227906 no 3102 0.0780938853987829 4440 1494643
SGTC_1503 4585-0012 61.3 µM -1.41887183186804 0.0928852302435355 no 3103 0.0779681929153718 4465 2922052
SGTC_1590 st077108 57.8 µM -1.42463506273532 0.0919945005861214 no 3104 0.0771313595552881 4459 5489485
SGTC_2076 5212012 200 µM -1.42813527260166 0.0914566258257455 no 3105 0.0766264633474381 4423 604802
SGTC_1014 4130-3005 69.3 µM -1.42841220763559 0.0914141691323251 no 3106 0.076586623744116 4472 743608
SGTC_2338 7999974 200 µM -1.42843550411117 0.0914105982341839 no 3107 0.0765832730544439 4454 315925
SGTC_2925 9010536 32.5 µM -1.43154380573646 0.0909350825625818 no 3108 0.0761372108404096 4372 2994177
SGTC_987 1497-1013 404 µM -1.4341130347741 0.0905434228499725 no 3109 0.0757700043760728 4473 1676435
SGTC_2268 7933382 153.85 µM -1.43509581629514 0.0903939367698449 no 3110 0.0756298977960847 4495 935025 YOR257W CDC31
SGTC_2409 alverine citrate 63.97 µM -1.43656183995686 0.0901712877989092 no 3111 0.0754212665391836 4492 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2383 9036125 200 µM -1.43838510287455 0.0898949526459053 no 3112 0.0751624085490206 4406 79580
SGTC_2545 solidagenone 89.61 µM -1.43992217135174 0.0896624827033161 no 3113 0.0749447097891585 4373 6708572 An anti ulcer agent
SGTC_2482 5981709 142.65 µM -1.44253799806281 0.0892678868482489 no 3114 0.0745753300701264 4401 877755
SGTC_1063 disulfiram 1.84 µM -1.44348573848366 0.0891252401096334 no 3115 0.0744418435461957 4479 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2616 abietic acid 100 µM -1.44893412971876 0.0883084786836722 no 3116 0.0736779893807802 4489 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_3322 9139058 2.11 µM -1.4543403090108 0.0875035717362606 no 3117 0.0729259900766981 4500 4908926 YPR165W RHO1
SGTC_2038 4100038 30.985 µM -1.45473435030439 0.087445119104528 no 3118 0.0728714095174189 4432 3596803
SGTC_145 3737-0113 38.366 µM -1.45619763886756 0.0872283079038604 no 3119 0.0726689960329294 4450 6849351
SGTC_881 0833-0569 170 µM -1.45786915798982 0.0869811351916651 no 3120 0.0724383056261011 4496 5418700
SGTC_1482 3346-2049 8.48 µM -1.45957200076305 0.0867298689169432 no 3121 0.0722038695177506 4506 3826804
SGTC_1011 4112-3381 17.4 µM -1.46198755383085 0.0863743683209676 no 3122 0.0718723102709516 4513 2877139
SGTC_1882 5615643 20 µM -1.46737305828369 0.0855857000551516 no 3123 0.0711372996760119 4434 2253075
SGTC_1775 st081588 35.1725 µM -1.47278607711825 0.0847984485668939 no 3124 0.0704043638538734 4466 1426443 YGL099W LSG1
SGTC_3168 9103419 49.47 µM -1.47488310614056 0.0844949271862907 no 3125 0.070121986488755 4518 16649256
SGTC_2425 5628681 7.85 µM -1.47803414149206 0.0840403837399918 no 3126 0.0696993200606733 4526 5714958
SGTC_2342 7990637 118.86 µM -1.4805913456343 0.0836728531818095 no 3127 0.069357751472504 4459 2033102 YER133W GLC7
SGTC_1644 st010134 20.9 µM -1.4893794150416 0.0824190041431929 no 3128 0.0681937430239405 4468 3818134
SGTC_1487 3970-0795 2.82 µM -1.48993562001431 0.0823401254919134 no 3129 0.0681205823083228 4536 3765103
SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.49044653973647 0.0822677191089802 no 3130 0.068053431616124 4488 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1899 st063254 59.6 µM -1.49177577599209 0.0820795674366965 no 3131 0.0678789681900993 4453 3093813
SGTC_1025 k007-0731 70 µM -1.49576344236978 0.0815170635097306 no 3132 0.0673576555540286 4470 6256118
SGTC_2776 terbinafine 19.92 µM -1.49721455303072 0.0813130915044469 no 3133 0.0671687199135131 4498 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_431 k089-0097 107 µM -1.49832027355345 0.0811579271012971 no 3134 0.0670250296009941 4221 5499420
SGTC_62 0180-0423 3.232 µM -1.50011661308063 0.0809063254558488 no 3135 0.0667920991439338 4451 30102 YGL099W LSG1
SGTC_2071 5230951 39.92 µM -1.50247895441528 0.0805763445295705 no 3136 0.0664867295770512 4528 1799272
SGTC_340 k038-0059 454 µM -1.50308762312055 0.0804914882742134 no 3137 0.0664082250100475 4478 23733424
SGTC_1297 1068-0111 14.1 µM -1.50538004107005 0.0801725015674155 no 3138 0.0661131987276844 4497 767057
SGTC_2386 9075165 157.42 µM -1.50719375955485 0.0799208029974208 no 3139 0.0658804996850759 4477 16452277
SGTC_2641 levomentholum 100 µM -1.50828108876786 0.0797701957736439 no 3140 0.0657413006014772 4504 16666
SGTC_658 3253-0951 102 µM -1.51720653385007 0.0785420255962542 no 3141 0.064607273595741 4521 1184878
SGTC_2861 9024595 19.48 µM -1.51979025984547 0.0781891854856228 no 3142 0.0642818489408876 4440 16482810
SGTC_677 0929-0063 136 µM -1.52054440846017 0.0780864240690801 no 3143 0.0641871032289577 4538 1539583
SGTC_1587 estradiol valerate 56.1 µM -1.52074773325476 0.0780587362717112 no 3144 0.0641615775769796 4553 13791 A steroid.
SGTC_176 1486-1328 72.834 µM -1.52453361409465 0.0775445526347651 no 3145 0.0636877332702148 4527 22310231
SGTC_752 1896-0090 130 µM -1.52602033962156 0.0773433361215945 no 3146 0.0635023995656649 4501 772567
SGTC_1624 st003710 6.25 µM -1.52686128654477 0.0772296963712229 no 3147 0.0633977539791199 4542 24207033
SGTC_2941 9056145 11.23 µM -1.52910072660876 0.0769276926610915 no 3148 0.0631197376333642 4454 2119517
SGTC_1193 1488-0126 41.5 µM -1.52949966474222 0.0768739874749441 no 3149 0.0630703110560275 4487 1384710
SGTC_1257 0669-0121 16 µM -1.5336890984636 0.0763117246234359 no 3150 0.0625530784802198 4502 4307855
SGTC_2623 humulene 100 µM -1.53795308202558 0.0757426754706763 no 3151 0.0620300434734999 4493 6187145 An anti-inflammatory.
SGTC_142 0335-0849 62.6745 µM -1.53902464090018 0.0756001802545555 no 3152 0.061899140380267 4482 3889043 YPR107C YTH1
SGTC_1433 4060-0023 7.6 µM -1.54204187896128 0.0752000471085264 no 3153 0.0615317085638687 4528 3840627
SGTC_1269 0831-0796 3.05 µM -1.54295962547965 0.0750786603313635 no 3154 0.0614202861556082 4551 927758
SGTC_2843 9000894 45.46 µM -1.54349424297549 0.075008017453913 no 3155 0.0613554516258466 4506 2242070
SGTC_2798 7813637 45.45 µM -1.54605070986582 0.074670913634034 no 3156 0.0610461607111133 4504 956368
SGTC_2647 atorvastatin 60.16 µM -1.54658191977047 0.074601011918569 no 3157 0.0609820461401509 4496 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1146 3579-1023 7 µM -1.54906802693357 0.0742745296742273 no 3158 0.0606826839645636 4528 X1146
SGTC_3039 9090270 49.47 µM -1.55529993534209 0.0734609352045378 no 3159 0.0599373263803049 4525 17173750
SGTC_1475 4092-1048 11.7 µM -1.55737987892666 0.0731909146689581 no 3160 0.0596901602211934 4533 2881759
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.56016983435653 0.0728299129251315 no 3161 0.0593598760847924 4596 688801
SGTC_2049 5262831 67.185 µM -1.57057545857424 0.0714955096689297 no 3162 0.0581406470756834 4481 763417
SGTC_1492 4158-0558 28.5 µM -1.57131688270788 0.0714011512377978 no 3163 0.0580545308016686 4539 3967268
SGTC_3116 9124943 49.47 µM -1.57342305596903 0.0711336273988218 no 3164 0.0578104459205447 4518 41905195 YPL160W CDC60
SGTC_1738 st035555 74 µM -1.57416977616924 0.0710389648462725 no 3165 0.0577241023389417 4532 5331140
SGTC_760 0568-0725 82.9 µM -1.5827858231135 0.0699536861712171 no 3166 0.0567351445344741 4546 3916171
SGTC_3108 9121785 49.47 µM -1.58741443210711 0.0693759573673202 no 3167 0.0562094063827853 4408 17140271
SGTC_3024 9090631 49.47 µM -1.5914755891279 0.0688720892160558 no 3168 0.0557512924167485 4510 25236383
SGTC_2863 9028737 58.44 µM -1.59456470448948 0.068490715112783 no 3169 0.0554048053396899 4531 6460917
SGTC_818 4072-2707 53.5 µM -1.59502194986332 0.0684344034810518 no 3170 0.0553536637133086 4475 882871
SGTC_76 0433-0009 400.328 µM -1.59662447720055 0.0682373276485736 no 3171 0.0551747196939995 4588 2841569
SGTC_355 1311-2252 105 µM -1.5969850017152 0.0681930514276031 no 3172 0.0551345252513539 4514 5338538
SGTC_669 0108-0021 26.2 µM -1.5986318655077 0.0679910810882282 no 3173 0.0549512124898235 4546 17201
SGTC_2618 avocadyne 43.43 µM -1.60471208022503 0.0672494059690692 no 3174 0.0542785910913419 4490 3015189
SGTC_1499 4480-0877 67.3 µM -1.60568467902242 0.0671313491893955 no 3175 0.0541716046327275 4538 2861909
SGTC_867 0518-0118 155 µM -1.60768479015068 0.0668890738013864 no 3176 0.0539521156948461 4527 6848158
SGTC_793 0488-0545 106 µM -1.61092376648845 0.0664981688251218 no 3177 0.0535981695935259 4574 292548
SGTC_786 4544-0069 423 µM -1.61406559129768 0.0661206808759179 no 3178 0.0532565999338368 4545 748821 YLR208W SEC13
SGTC_748 act1.228 77.9 µM -1.61619261046687 0.0658660648630258 no 3179 0.05302633797984 4540 4421505 YNR035C ARC35
SGTC_2020 4017018 200 µM -1.6189669422445 0.0655351046653557 no 3180 0.0527271880111644 4572 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.62916717862426 0.0643293586514325 no 3181 0.0516388165005079 4556 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1226 3909-7979 35.4 µM -1.63195787191373 0.0640024991947183 no 3182 0.0513441806274116 4551 6615510
SGTC_2155 5570423 76 µM -1.63515624264471 0.0636294803265988 no 3183 0.0510081492096504 4554 797402
SGTC_1973 st070275 50.2 µM -1.63709852653613 0.0634037829491654 no 3184 0.0508049422136337 4545 17118334
SGTC_2593 nobiletin 86.24 µM -1.64064060144191 0.0629937915559028 no 3185 0.0504360208221169 4528 72344 An anti-infammatory.
SGTC_1285 0929-0069 65.5 µM -1.64191921134685 0.0628463021414232 no 3186 0.0503033739538088 4603 1206237
SGTC_1971 st069429 63.5 µM -1.64913562767283 0.0620189176075668 no 3187 0.0495599260585281 4570 1246522 YGL099W LSG1
SGTC_119 0121-0043 24.815 µM -1.65234765257571 0.0616533934735946 no 3188 0.0492318501351841 4574 1092378
SGTC_2145 5634607 200 µM -1.65420165047199 0.0614431779430521 no 3189 0.0490432738181619 4579 308662
SGTC_3257 9139206 32.98 µM -1.65532846925514 0.0613156874072114 no 3190 0.0489289435256079 4552 4910041
SGTC_2153 5569715 200 µM -1.6553681695887 0.0613111994038234 no 3191 0.0489249193018894 4589 2054701
SGTC_2778 tioconazole 65.09 nM -1.6567873922156 0.0611509290698809 no 3192 0.0487812334460718 4467 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_442 cape 100 µM -1.65964954121625 0.0608287077087777 no 3193 0.0484924878982786 4605 5281787
SGTC_1324 1418-0026 34.4 µM -1.66192217008583 0.0605738015309716 no 3194 0.0482641904106625 4589 1372513
SGTC_1476 4112-3294 3.34 µM -1.66263585496985 0.0604939247356143 no 3195 0.0481926746916059 4550 704369
SGTC_2115 tiliquinol 12.7705 µM -1.6632249164106 0.0604280581058489 no 3196 0.0481337109178978 4554 71208 A bioactive hydroxyquinoline.
SGTC_2820 7989630 71.43 µM -1.66476976374532 0.0602555856674373 no 3197 0.0479793492347321 4610 2984098
SGTC_1680 diphenhydramine 100 µM -1.66537650606453 0.0601879522039769 no 3198 0.0479188318056645 4525 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_846 0335-0850 148 µM -1.66630380276964 0.0600847014356385 no 3199 0.0478264598516171 4568 6819598
SGTC_1563 conessine 56.1 µM -1.66929342687149 0.059752762923943 no 3200 0.0475296211317658 4629 441082 An anti-amoebic, histamine inhibitor.
SGTC_2753 fluvastatin 17.09 µM -1.66971454863247 0.0597061213613959 no 3201 0.0474879269452168 4557 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1477 0139-0234 16 µM -1.66992546177416 0.0596827722887751 no 3202 0.0474670559909751 4595 620880
SGTC_286 k060-0067 22.9 µM -1.67389332112098 0.0592448437502753 no 3203 0.047075783525953 4612 5985051
SGTC_1520 flindersine 88 µM -1.67649192343655 0.0589594069102639 no 3204 0.0468209384481063 4588 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1463 k081-0032 34.1 µM -1.68165847195618 0.0583951066280227 no 3205 0.0463175425786922 4089 977755
SGTC_1687 st020778 55.3625 µM -1.68453033237296 0.0580832757247988 no 3206 0.0460396112564362 4611 4259299
SGTC_136 0097-0015 404.482 µM -1.68682416552241 0.0578351490788769 no 3207 0.0458185836657862 4577 4861337
SGTC_1641 st009299 47.1 µM -1.68813599536515 0.0576936218927281 no 3208 0.0456925630694736 4525 4046054
SGTC_2900 5328528 85.29 µM -1.69803202774407 0.0566347439046619 no 3209 0.0447508585667587 4576 795359
SGTC_1021 4476-0760 85.3 µM -1.699045072391 0.0565272174487115 no 3210 0.0446553457427188 4608 746768
SGTC_1828 st055811 49 µM -1.71041741670048 0.0553311454293036 no 3211 0.0435943563093413 4587 5877589
SGTC_2114 5491910 81.25 µM -1.71855796767425 0.0544873136370776 no 3212 0.0428474453782191 4600 2849228
SGTC_1967 st070177 51.4 µM -1.73081806324797 0.0532357036015386 no 3213 0.0417421095742572 4603 5729214
SGTC_1200 1643-0193 18.4 µM -1.74188942007678 0.0521251339503251 no 3214 0.0407638977990201 4619 5403974
SGTC_2138 5575593 77.673 µM -1.74434104636029 0.0518817171506048 no 3215 0.0405498191445656 4616 762213
SGTC_2549 cedrol 20.94 µM -1.74956554506635 0.051366001589308 no 3216 0.0400966547223962 4574 6708665 A sedative which affects the nervous system.
SGTC_2691 st077356 60.2 µM -1.75948899501484 0.0503976818993868 no 3217 0.0392472439155312 4583 2839272
SGTC_1512 0259-0544 12.2 µM -1.77301571552786 0.0491012488476179 no 3218 0.0381130513955076 4596 18476
SGTC_1954 st077032 68.9 µM -1.7800329763565 0.048439268924256 no 3219 0.0375352820457975 4562 698907
SGTC_2914 7968218 45.32 µM -1.7847957623386 0.0479940471975132 no 3220 0.0371472254871269 4607 2977111
SGTC_1666 st014829 29 µM -1.78799359842233 0.0476969580080743 no 3221 0.0368885203207275 4646 3858230
SGTC_1620 st003704 16.5 µM -1.7913095496108 0.0473904527533145 no 3222 0.0366218172635838 4639 2834414
SGTC_1698 5-fluorocytosine 1.055 µM -1.79301283717879 0.0472336264487796 no 3223 0.0364854357249933 4632 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2280 7785178 200 µM -1.79405054079265 0.047138286352813 no 3224 0.0364025511403408 4611 2954328
SGTC_1969 st069479 40.1 µM -1.80715074929218 0.04594791006302 no 3225 0.0353693888288726 4618 3895485
SGTC_2287 7945887 168.79 µM -1.8100066975259 0.0456916325683172 no 3226 0.0351473742751469 4643 1245853
SGTC_2794 7785382 27.27 µM -1.81059736805322 0.0456387726223521 no 3227 0.0351015999588855 4609 2205081
SGTC_2748 diazoxide 86.69 µM -1.81961466390064 0.0448378898644973 no 3228 0.0344088534881541 4710 3019 A potassium channel activatior.
SGTC_1617 st002906 78 µM -1.82886349869647 0.0440282371774683 no 3229 0.0337100297794983 4624 5150859
SGTC_2866 9034245 58.44 µM -1.82895256475202 0.0440204979383866 no 3230 0.0337033573271221 4649 6462273
SGTC_3000 9075062 71.4286 µM -1.82922088827185 0.0439971890659532 no 3231 0.0336832622319643 4624 17057871
SGTC_1832 st054113 55 µM -1.83105762616074 0.0438379014551362 no 3232 0.0335459711528001 4655 1251267
SGTC_83 0170-0301 39.027 µM -1.83430289267602 0.0435575991889903 no 3233 0.0333045225098112 4660 3089716
SGTC_544 k015-0020 52.4 µM -1.83484628804824 0.0435108063829341 no 3234 0.0332642339838538 4662 3008304
SGTC_3226 9131256 49.47 µM -1.83813747627093 0.0432282623591231 no 3235 0.0330210750540876 4665 17178073
SGTC_2245 6637752 200 µM -1.84882652703752 0.0423208289634609 no 3236 0.0322414328176311 4647 681890
SGTC_2408 sulbentine 18.36 µM -1.84891519049318 0.0423133669386039 no 3237 0.0322350299398253 4511 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2046 4110841 106 µM -1.85614929151316 0.0417081135082303 no 3238 0.0317161407804819 4655 44119630 YMR134W ERG29
SGTC_2899 9053889 58.44 µM -1.86043457930989 0.0413528973571722 no 3239 0.0314120330917773 4652 6470052
SGTC_2404 5161160 200 µM -1.86534330979606 0.0409490200229018 no 3240 0.0310666490482058 4609 2831543
SGTC_2752 diclazuril 33.15 µM -1.87013021717815 0.0405582532230893 no 3241 0.0307328686203225 4561 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2266 7929956 200 µM -1.87774353634916 0.0399430000091853 no 3242 0.0302081289159199 4622 2967153
SGTC_3144 9087057 49.47 µM -1.89182449856542 0.0388250762605287 no 3243 0.0292571840145455 4587 17249618
SGTC_2828 7998861 71.43 µM -1.90853731326002 0.0375314177980112 no 3244 0.0281609026396401 4665 2988188
SGTC_2007 4011539 71.82 µM -1.91678708384945 0.0369059402327122 no 3245 0.0276324932545902 4642 45595301
SGTC_1830 st055982 50.3 µM -1.92603641107725 0.0362148396490314 no 3246 0.027049913784165 4655 455313 An antimicrobial agent.
SGTC_1391 3442-0225 151 µM -1.93579803765112 0.0354969894939395 no 3247 0.0264462206826715 4668 5227075
SGTC_2185 6113692 200 µM -1.9384514367466 0.0353038933411932 no 3248 0.0262840850984067 4662 874150
SGTC_775 4577-0580 57.3 µM -1.94001162745434 0.0351907561815253 no 3249 0.0261891384041939 4671 2006902
SGTC_1198 1612-1005 86.7 µM -1.9407647298933 0.0351362515287784 no 3250 0.0261434104568689 4704 6998509
SGTC_2975 9084847 53.72 µM -1.94662343240627 0.0347145980613073 no 3251 0.025789948612392 4641 27211724
SGTC_1616 st002734 56.1 µM -1.94856416040785 0.0345758425871781 no 3252 0.0256737478334977 4660 4026101
SGTC_2931 9014674 55.67 µM -1.95345669801328 0.0342280637133571 no 3253 0.0253827517512557 4632 2996810
SGTC_1889 st059080 5.18 µM -1.95661366492179 0.034005185459749 no 3254 0.0251964535979799 4651 176925 Isolated from Daphnopsis sellowiana.
SGTC_1202 1988-0068 29.6 µM -1.96774166955862 0.0332290600309845 no 3255 0.0245488843569193 4662 2850480
SGTC_1935 st074532 41.6 µM -1.96789770341879 0.0332182820178333 no 3256 0.0245399045592885 4645 2829742
SGTC_2839 9003951 25.97 µM -1.97064136834791 0.0330292338377333 no 3257 0.0243824556550606 4715 2990634
SGTC_2537 larixol 68.93 µM -1.97402523920336 0.032797295116939 no 3258 0.0241894365697172 4654 6708759
SGTC_734 2023-0417 80 µM -1.97408713263695 0.0327930653275184 no 3259 0.0241859180982684 4672 3935732
SGTC_2906 7926292 26.41 µM -1.97784437897486 0.0325371366467607 no 3260 0.0239731326331158 4660 2966319
SGTC_1572 epiandrosterone 68.9 µM -1.98682931938752 0.0319317939590695 no 3261 0.0234706571761987 4651 441302 A steroid.
SGTC_2367 9070478 135.38 µM -1.99177076952297 0.031602857366495 no 3262 0.0231981074009306 4628 572802
SGTC_3101 9120531 49.47 µM -2.00084359969309 0.0310061998263196 no 3263 0.0227046235924294 4644 24824904
SGTC_538 2922-0838 53.3 µM -2.00096905665386 0.0309980151819437 no 3264 0.0226978623196088 4702 777039
SGTC_1264 0783-0040 158 µM -2.00388151348161 0.03080851233748 no 3265 0.0225413771419484 4612 2855798
SGTC_2976 9009005 19.48 µM -2.00991614116822 0.0304189128698703 no 3266 0.0222200325480675 4658 2993148
SGTC_1439 4092-1168 46 µM -2.01115855908414 0.0303392103915365 no 3267 0.0221543557222171 4705 2886240
SGTC_1422 4031-0024 15.5 µM -2.01508485831563 0.0300884707652359 no 3268 0.0219478792416386 4655 782427
SGTC_2441 5730946 39.09 µM -2.01587400307915 0.0300382826711641 no 3269 0.02190657634394 4691 1774275
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -2.01914468114545 0.029831013293813 no 3270 0.0217360920005846 4722 66535 A nucleotide analog.
SGTC_1946 st076057 65.1 µM -2.01976636154983 0.0297917506645157 no 3271 0.0217038139530469 4679 953009
SGTC_2359 9039622 200 µM -2.02754289860762 0.0293042305760731 no 3272 0.0213034609583013 4658 6463596
SGTC_531 3788-1495 174 µM -2.02887716640218 0.0292212533754572 no 3273 0.0212354015019227 4686 2896655
SGTC_1630 st005209 31.3 µM -2.03129794453774 0.0290712051010311 no 3274 0.0211123898848606 4685 3367314
SGTC_173 1273-0061 2.693 µM -2.04156428485092 0.0284419585359321 no 3275 0.0205973855402105 4648 2847414 YPL266W DIM1
SGTC_291 SEC14.278 35.5 µM -2.05201236088369 0.0278132494871392 no 3276 0.0200842305716116 4708 1068044
SGTC_2736 butenafine 14.65 µM -2.06777643937724 0.0268865974899617 no 3277 0.0193305250815709 4659 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3025 9087895 49.47 µM -2.08174252659869 0.0260873050541629 no 3278 0.0186829969778384 4710 17173641
SGTC_2742 clothiapine 36.27 µM -2.10256629498347 0.0249325145864993 no 3279 0.0177518494126 4730 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_3119 9125183 49.47 µM -2.10334504854855 0.0248901735380637 no 3280 0.0177178091192113 4680 22695334
SGTC_1656 st012921 11 µM -2.11142365418887 0.0244544840182229 no 3281 0.0173679568458422 4629 6732821
SGTC_2764 methyldopa 94.69 µM -2.11357472749934 0.0243395590942198 no 3282 0.0172758031371596 4680 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2876 9059903 25.97 µM -2.11583367437281 0.0242193593452017 no 3283 0.0171794780038236 4704 6916095
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -2.12950171058685 0.0235026632957554 no 3284 0.0166063867552087 4667 17037758
SGTC_2302 7771753 200 µM -2.13617568840938 0.0231592417726391 no 3285 0.0163325481417948 4667 2203047
SGTC_1448 4255-0083 152 µM -2.14036869708704 0.0229456514529933 no 3286 0.0161624911009388 4725 5399660
SGTC_2170 morpholine 200 µM -2.15117137380421 0.0224029992124321 no 3287 0.0157313378073625 4725 121171 Reacts with secondary amines.
SGTC_2322 7413319 38.22 µM -2.15803919530335 0.022063666587162 no 3288 0.0154623922714618 4641 1840400
SGTC_367 0335-0881 7.1 µM -2.15869085623099 0.0220316951911674 no 3289 0.0154370793216178 4648 23828853
SGTC_3297 9117502 71.43 µM -2.15951312239488 0.0219914094791853 no 3290 0.0154051901975666 4724 7453720
SGTC_2001 4023502 57.655 µM -2.1599794942736 0.0219685879325056 no 3291 0.0153871285137055 4691 108941 YCR052W RSC6
SGTC_1234 0326-0494 15.5 µM -2.17258455039513 0.0213593008215356 no 3292 0.0149057998614147 4749 1547813
SGTC_3136 9095672 49.47 µM -2.18765041548507 0.0206498693823382 no 3293 0.0143475382370711 4635 17217380
SGTC_1379 2144-0755 36.5 µM -2.22043896781644 0.0191746466960811 no 3294 0.0131944921622284 4734 5392327
SGTC_410 α-linolenic acid 100 µM -2.22405573465187 0.0190175469657204 no 3295 0.0130723473001173 4741 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_877 0771-0151 33.1 µM -2.23011643587413 0.0187567452866001 no 3296 0.0128698569771751 4740 6166523
SGTC_3014 9081533 49.47 µM -2.23144644304455 0.0186999219858263 no 3297 0.012825785691273 4727 21367265
SGTC_1191 1487-1166 10.6 µM -2.28879314790103 0.0163854097218536 no 3298 0.0110456868962008 4733 3955771
SGTC_2825 7998094 58.44 µM -2.2893718023383 0.0163633656513041 no 3299 0.0110288795223538 4699 2987815
SGTC_996 3970-0799 1.8 µM -2.29401703283152 0.0161873222274514 no 3300 0.01089476019456 4682 6615648 YGL040C HEM2
SGTC_1220 1838-0075 193 µM -2.29463224328314 0.0161641293058191 no 3301 0.0108771044152636 4692 5529645
SGTC_1550 gossypolone 36.6 µM -2.31479476001688 0.0154196199594651 no 3302 0.0103120834209903 4753 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1354 1498-1681 81 µM -2.31711803913492 0.0153357539177219 no 3303 0.0102486513043053 4755 5754243
SGTC_2932 9016711 44.54 µM -2.33039234918603 0.014864051225059 no 3304 0.00989271188717529 4723 7117328
SGTC_2328 6201408 200 µM -2.35784223551271 0.0139280663957711 no 3305 0.00919075152199715 4711 2890418
SGTC_591 4299-0174 154 µM -2.36157204392985 0.0138048944056723 no 3306 0.00909881784905795 4766 5509088
SGTC_1777 st045864 34.765 µM -2.37627578519905 0.0133284315208696 no 3307 0.00874419316486652 4758 4691462
SGTC_320 4092-0846 5.34 µM -2.38749568935714 0.0129744771776157 no 3308 0.00848180084604603 4730 1359356
SGTC_1903 st060211 78.3 µM -2.38797813538999 0.0129594414382622 no 3309 0.00847067482284948 4747 688960
SGTC_1892 st058411 7.36 µM -2.39833433960866 0.0126402973269596 no 3310 0.00823491224716234 4743 3934738
SGTC_858 0438-0351 2.77 µM -2.41270623840454 0.0122086849463397 no 3311 0.00791728807465803 4754 2799119
SGTC_2284 7945075 39.21 µM -2.42245677775962 0.0119231840786254 no 3312 0.00770797975781736 4713 1245402
SGTC_2898 9056270 58.44 µM -2.42376837562994 0.0118852251924592 no 3313 0.00768019949056634 4768 19154699
SGTC_1643 st009866 20.2 µM -2.46378369186856 0.0107764622382629 no 3314 0.00687395256642137 4759 3156273 YOR207C RET1
SGTC_3139 9095020 49.47 µM -2.47419418109024 0.0105032023531018 no 3315 0.00667685468800851 4708 25236292
SGTC_2692 st077426 47.7 µM -2.47894816442127 0.0103804387106953 no 3316 0.00658852272221959 4746 25238571
SGTC_82 0054-0107 293.755 µM -2.48072413957319 0.0103348990992031 no 3317 0.00655579006060324 4749 3104697
SGTC_2107 5363541 170.161 µM -2.50028097767139 0.00984482934173439 no 3318 0.00620474199417009 4738 244052
SGTC_1222 0366-0074 1.18 µM -2.51203411718696 0.00956017813762579 no 3319 0.00600187415843002 4765 286520
SGTC_2934 9036370 36.88 µM -2.52037520511921 0.00936255375390442 no 3320 0.00586148996434125 4734 6462800
SGTC_1462 k081-0014 26.5 µM -2.52676678269741 0.00921354642113475 no 3321 0.00575589594619258 4292 3270634
SGTC_2480 5767542 37.17 µM -2.65413562847741 0.00664755906984159 no 3322 0.00397559304034374 4742 2867358
SGTC_2050 5263056 171 µM -2.71382153328139 0.00567952101443326 no 3323 0.00332559937076842 4752 763468 YGL055W OLE1
SGTC_2021 4019055 173 µM -2.72330156475742 0.0055378661381791 no 3324 0.00323165151857094 4656 44827708 YER133W GLC7
SGTC_3002 9075603 71.4286 µM -2.72901570527433 0.00545400704027402 no 3325 0.00317618392559866 4765 20105405
SGTC_3348 9149464 3.537 µM -2.73203878724242 0.0054100992205437 no 3326 0.00314718651567399 4769 1951442
SGTC_2478 5763493 32.33 µM -2.73352322876877 0.00538865415661723 no 3327 0.0031330351668078 4764 1365576 YLR208W SEC13
SGTC_1219 1469-0211 33.1 µM -2.76345010911114 0.00497213586424117 no 3328 0.00285969175945836 4779 6822282
SGTC_783 0848-0141 92.7 µM -2.77916266628065 0.00476514221586018 no 3329 0.00272496130799109 4761 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1177 0983-0204 23.6 µM -2.85079913707898 0.00391559501341671 no 3330 0.00218047542250228 4791 766818
SGTC_2857 9024691 58.44 µM -2.87436836498835 0.0036673411771139 no 3331 0.00202418243807571 4763 16478292
SGTC_3337 9144342 33.5465 µM -2.90863714538488 0.00333155566348729 no 3332 0.00181503958517965 4783 17682949
SGTC_2085 5307070 144.047 µM -2.91276573119608 0.0032930258567022 no 3333 0.00179121625045537 4771 2840351
SGTC_2909 7941780 10.49 µM -2.91972334061288 0.00322900017666798 no 3334 0.00175171127098562 4777 1243215
SGTC_2017 5132927 60.65 µM -2.92381318713422 0.00319188912826012 no 3335 0.00172886096407879 4773 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_651 3253-0966 34.4 µM -2.94525479007619 0.00300353755651952 no 3336 0.00161344406581181 4787 781462
SGTC_3354 9151612 71.43 µM -2.94866303312056 0.00297453840955981 no 3337 0.00159575876248633 4775 27261949
SGTC_1217 1183-1422 255 µM -2.98755980467022 0.0026610088103198 no 3338 0.00140607134694644 4790 2849664
SGTC_293 4049-0273 38.5 µM -3.04782517015862 0.0022338611004105 no 3339 0.00115251994971714 4765 1380311
SGTC_611 3453-1652 23.7 µM -3.05196778992718 0.00220691720281022 no 3340 0.00113673247644646 4782 1560575
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -3.10333269853031 0.00189645487884543 no 3341 0.000956771957425081 4804 16486 A toxic proline analog.
SGTC_1906 st060206 94.7 µM -3.10544602086734 0.00188457627650193 no 3342 0.000949961474844094 4791 5133468
SGTC_1554 st069299 38.7 µM -3.10901612661978 0.00186466287468181 no 3343 0.000938557361760035 4791 24207999
SGTC_660 4031-1742 102 µM -3.14336072768369 0.00168263972706587 no 3344 0.000835099370302943 4748 6738706
SGTC_2270 7924575 90.91 µM -3.16465578432847 0.0015780615929386 no 3345 0.000776332590390194 4784 1262135
SGTC_2693 st077581 40.7 µM -3.19144419509035 0.00145492989965444 no 3346 0.000707817274555918 4780 25238761
SGTC_1401 3807-4679 7.6 µM -3.22404567719514 0.00131693420487014 no 3347 0.000631966186578226 4762 3291456
SGTC_1546 5-methoxyflavanone 78.7 µM -3.22900946817778 0.00129700591129782 no 3348 0.000621098910510002 4806 147795
SGTC_2624 nerol 100 µM -3.36873432865609 0.000837487716847165 yes 3349 0.000377570885828468 4779 637566 A natural product oil.
SGTC_3345 9148410 3.559 µM -3.54596969117016 0.000469999963997732 yes 3350 0.00019558559764167 4792 4903596
SGTC_3021 9087658 49.47 µM -3.64611564015518 0.000335285691409356 yes 3351 0.00013311710188831 4806 25237042
SGTC_40 0327-0103 19.753 µM -4.37390610095612 2.24785912404909e-05 yes 3352 6.10214450327963e-06 4775 409036
SGTC_2305 7443522 69.23 µM -4.96024524442012 1.85059856025116e-06 yes 3353 3.52021189585134e-07 4806 5415886
SGTC_2699 st077704 54.6 µM -5.24117966259586 5.05154602976874e-07 yes 3354 7.97766355101038e-08 4809 645852
SGTC_2851 9015922 71.43 µM -5.82006425580154 2.82163445813798e-08 yes 3355 2.94125042209147e-09 4810 2996893
SGTC_2852 9023854 51.95 µM -6.91521218959504 5.53432725313461e-11 yes 3356 2.3358179211737e-12 4810 19798528