SGTCid condition conc unit TRP1|YDR007W.score TRP1|YDR007W.strain.pval TRP1|YDR007W.strain.significant TRP1|YDR007W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_129 0088-0017 176.636 µM 27.8803889687475 5.53257446548846e-52 yes 1 2.30680151779737e-171 1 182446 SGTC_2607 solasodine 47.35 µM 27.3027408747051 6.27208324225164e-50 yes 2 1.96769531292378e-164 4 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1883 5-benzylidenerhodanine 20 µM 25.3994408549118 1.83610399413823e-43 yes 3 1.27899617336783e-142 1 1273210 SGTC_2488 5268135 45.7 µM 25.1250763201331 1.43795549655745e-42 yes 4 1.32341439280794e-139 2 1270356 YLR208W SEC13 SGTC_2384 9036245 200 µM 24.0252419437518 4.40569060372822e-39 yes 5 7.57609649016414e-128 1 6462766 SGTC_3308 9128332 17.569 µM 23.559149921772 1.18760872038278e-37 yes 6 5.0578801923645e-123 4 17332805 YDL196W YDL196W SGTC_2038 4100038 30.985 µM 22.9350673936212 8.84511293184873e-36 yes 7 1.03843511844741e-116 4 3596803 SGTC_1882 5615643 20 µM 22.3724680553951 3.90440630491108e-34 yes 8 3.64925937164006e-111 1 2253075 SGTC_2758 dehydroepiandrosterone 69.35 µM 21.7518268006259 2.28609014304381e-32 yes 9 3.31915896284999e-105 5 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2618 avocadyne 43.43 µM 21.3698553901447 2.64491255911177e-31 yes 10 1.2746058040765e-101 5 3015189 SGTC_2540 epiandrosterone 100 µM 19.8887299459329 2.33896472167917e-27 yes 11 2.54745472260922e-88 1 441302 A steroid. SGTC_2137 5261020 140 µM 19.7994860979584 3.96153866702922e-27 yes 12 1.50373028394575e-87 1 763655 SGTC_180 1486-1293 102.781 µM 19.5772152409622 1.45676435651215e-26 yes 13 1.20943986723479e-85 3 4140536 SGTC_1715 st032160 10.2275 µM 19.2329492382059 1.06376904035793e-25 yes 14 9.80748349167706e-83 1 5289825 SGTC_1881 5652484 16 µM 19.2107479503359 1.20784437844624e-25 yes 15 1.50449794423338e-82 1 2255129 SGTC_2232 chlorophetanol 41.5365 µM 19.1970309825871 1.30635774200647e-25 yes 16 1.95930308613782e-82 5 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2254 7938975 95.19 µM 18.8813618263392 7.81703733899591e-25 yes 17 8.11728557082055e-80 4 2969277 SGTC_1999 st074831 12.5 µM 18.262670089321 2.39313467324794e-23 yes 18 8.20340103595949e-75 1 17112523 SGTC_2939 9044578 71.43 µM 18.244205921623 2.64583067525164e-23 yes 19 1.1502782137834e-74 4 2653634 SGTC_1636 st007707 68.9 µM 18.1966664536307 3.42456255757135e-23 yes 20 2.74227351051404e-74 2 403051 SGTC_207 4185-0010 4.486 µM 17.8346625788038 2.38963988495554e-22 yes 21 1.90169376575914e-71 5 3761753 SGTC_1482 3346-2049 8.48 µM 16.2816606092046 6.43175686007459e-19 yes 22 6.66023156232272e-60 3 3826804 SGTC_2093 5331342 194.4 µM 16.1907408283812 9.99116068017912e-19 yes 23 2.93092801801788e-59 3 33839 SGTC_2056 5235370 200 µM 14.9010362948366 3.97882693939125e-16 yes 24 1.62253536633388e-50 3 5511916 SGTC_1673 st016611 27.3 µM 14.78258349652 6.7291780520721e-16 yes 25 9.48730008792522e-50 4 5226799 SGTC_10 0279-0212 42.575 µM 14.5913391196543 1.55827940210632e-15 yes 26 1.59438194987275e-48 2 39851 YBR002C RER2 SGTC_1797 st048695 56.8 µM 14.492397229222 2.3960419116276e-15 yes 27 6.76679237172488e-48 6 592262 YIL048W NEO1 SGTC_1423 4048-0112 5.59 µM 14.359504625913 4.25111586758252e-15 yes 28 4.6444357570459e-47 1 X1423 SGTC_2454 5-benzylidenerhodanine 10.36 µM 14.1241486808235 1.15878653319818e-14 yes 29 1.34819308918412e-45 1 1273210 SGTC_134 0269-0018 6.916 µM 13.667166264559 7.75416365314506e-14 yes 30 7.9742973999437e-43 24 4378915 SGTC_19 0279-0214 38.434 µM 13.6569168858494 8.08624242654959e-14 yes 31 9.1796893077154e-43 2 3566274 YBR002C RER2 SGTC_1427 4048-4900 550 nM 13.6404824735496 8.64810102816745e-14 yes 32 1.15016813042011e-42 2 24132586 SGTC_1824 st053723 68.6 µM 13.6299042689102 9.02985629439545e-14 yes 33 1.32964457514616e-42 3 675225 SGTC_2036 5160441 105 µM 13.6210895829016 9.36057553594348e-14 yes 34 1.5002867915231e-42 9 134534 YIL048W NEO1 SGTC_2472 5377652 49.4 µM 13.6053130876385 9.98246190299198e-14 yes 35 1.86185186656279e-42 4 1610903 SGTC_819 1013-0258 27.7 µM 13.3929644364601 2.35597300845761e-13 yes 36 3.32368191446322e-41 2 5753198 SGTC_50 0929-0078 56.389 µM 13.2274433176722 4.55934338018135e-13 yes 37 3.04623726793071e-40 3 1377751 SGTC_723 4182-0001 115 µM 12.883847480601 1.75001387512247e-12 yes 38 2.77491875440649e-38 2 744821 YLR208W SEC13 SGTC_2486 5283202 22.39 µM 12.8442369998805 2.03902289884284e-12 yes 39 4.6330499792458e-38 4 1377751 SGTC_1572 epiandrosterone 68.9 µM 12.7359136317578 3.08987452918078e-12 yes 40 1.86724334944551e-37 5 441302 A steroid. SGTC_2752 diclazuril 33.15 µM 12.6591645959155 4.13945906330863e-12 yes 41 4.9776542568515e-37 13 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2478 5763493 32.33 µM 12.6023886899392 5.13352922589767e-12 yes 42 1.02422664037541e-36 3 1365576 YLR208W SEC13 SGTC_133 0724-0033 378.92 µM 12.4622375797452 8.69777940023553e-12 yes 43 5.9978474250532e-36 1 280309 SGTC_637 1181-0519 7.26 µM 12.4590153320063 8.80326993666664e-12 yes 44 6.24516293456067e-36 11 6252091 YGR060W ERG25 SGTC_1005 4092-0690 4.4 µM 12.3781900524514 1.18998889497876e-11 yes 45 1.71495323049769e-35 5 1529343 SGTC_51 1013-0126 23.419 µM 12.3539258237395 1.30220237634157e-11 yes 46 2.31955642152673e-35 6 1627850 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 12.203767591587 2.26575891384354e-11 yes 47 1.48383931491788e-34 1 1241132 A phosphatase inhibitor. SGTC_2524 avocatin b 10.57 µM 12.1481286614601 2.77726714026292e-11 yes 48 2.93468319723782e-34 2 6710748 SGTC_1304 1165-0502 251 µM 11.9393352151021 5.91402115173067e-11 yes 49 3.69053781947684e-33 5 767425 SGTC_2238 6671620 73.2395 µM 11.9139328095165 6.47806457002206e-11 yes 50 5.00700702567532e-33 1 729941 SGTC_1909 st060837 51.5 µM 11.8809787341542 7.28865797219544e-11 yes 51 7.43084821550476e-33 3 678937 SGTC_1041 0206-0046 107 µM 11.6181727714658 1.84536173797538e-10 yes 52 1.66593017630714e-31 5 50494 SGTC_2948 9070189 9.45 µM 11.6014902316735 1.95612713674923e-10 yes 53 2.02482133945094e-31 7 6473636 YDL196W YDL196W SGTC_542 3381-0244 89.3 µM 11.4304717253569 3.53910822360261e-10 yes 54 1.47252273133191e-30 5 1112843 SGTC_41 0478-0632 82.643 µM 11.2436846264174 6.69769110616192e-10 yes 55 1.24388693228122e-29 2 3750424 SGTC_2301 7769476 200 µM 11.2277123353064 7.06985400943904e-10 yes 56 1.49048390420722e-29 3 977820 SGTC_1697 st025554 27.742 µM 11.2222020079605 7.20286494083482e-10 yes 57 1.5863526074294e-29 3 1269519 SGTC_79 0052-0007 94.094 µM 11.1514349862526 9.14375231364262e-10 yes 58 3.52303882157825e-29 1 2801472 SGTC_1597 7-benzyloxygramine 47.5 µM 11.1435717648858 9.38856303879826e-10 yes 59 3.84846229240955e-29 13 260807 SGTC_2322 7413319 38.22 µM 11.0629430427986 1.22973246780081e-09 yes 60 9.48833900464111e-29 14 1840400 SGTC_2642 cholecalciferol 100 µM 11.0317114612691 1.36456089882806e-09 yes 61 1.34351124028208e-28 4 9821465 A vitamin D precursor, similar to steriods. SGTC_1510 1123-0200 71.5 µM 10.9677838625157 1.68691678315253e-09 yes 62 2.72970459644511e-28 5 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2286 7945697 125 µM 10.8962641692996 2.13561783148482e-09 yes 63 6.00435760794974e-28 3 1245733 SGTC_1757 st041620 31.8375 µM 10.8630464437487 2.38165618901933e-09 yes 64 8.6441824073178e-28 2 5289815 SGTC_1004 4084-0029 199 µM 10.8409391820026 2.56046338051452e-09 yes 65 1.10099381695344e-27 1 716894 YLR208W SEC13 SGTC_2725 haloperidol 53.21 µM 10.7070715341963 3.957172535859e-09 yes 66 4.71488157219108e-27 9 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1750 st081859 2.357 µM 10.5289111674091 7.00677071386413e-09 yes 67 3.17827355794353e-26 39 5291695 SGTC_1699 st031318 29.054 µM 10.2355277317327 1.75974952502317e-08 yes 68 6.87218894923984e-25 4 5340658 SGTC_1603 st002045 67.8 µM 10.0225697281378 3.38060105914223e-08 yes 69 6.06535800276394e-24 7 5887985 SGTC_3066 9117245 49.47 µM 9.98882700249769 3.74454968379218e-08 yes 70 8.52941880575053e-24 1 17176980 SGTC_748 act1.228 77.9 µM 9.86621336865059 5.41452877490254e-08 yes 71 2.91624749170526e-23 10 4421505 YNR035C ARC35 SGTC_2376 9072922 81.32 µM 9.77522816978849 7.09892462325731e-08 yes 72 7.19164355573505e-23 2 17087968 SGTC_1520 flindersine 88 µM 9.50198831174182 1.57847536471787e-07 yes 73 1.02960150654329e-21 4 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1160 4092-0570 10.5 µM 9.48373617394086 1.66374932946938e-07 yes 74 1.22668954208377e-21 4 4994975 SGTC_204 PMA1.184 62.41 µM 9.39014808583989 2.17569994045487e-07 yes 75 2.99579789515356e-21 4 2252213 YGL008C PMA1 SGTC_1617 st002906 78 µM 9.37215253124667 2.29021921209845e-07 yes 76 3.55340596415653e-21 8 5150859 SGTC_109 0132-0036 33.701 µM 9.30460307657702 2.77422268975909e-07 yes 77 6.7246867479399e-21 3 67274 A color developer. SGTC_1649 st011737 51.3 µM 9.25871586844536 3.15776153519045e-07 yes 78 1.03452763276569e-20 5 1761035 SGTC_1418 3966-3099 2.4 µM 9.24490459714828 3.28287718202478e-07 yes 79 1.17725329241058e-20 2 740335 SGTC_1511 0906-3109 28.5 µM 9.19625133356904 3.76280997691764e-07 yes 80 1.85327514713748e-20 5 2882180 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 9.19342275340241 3.79269839845181e-07 yes 81 1.90268016165987e-20 14 442882 SGTC_2249 haloperidol 116.36 µM 9.17623515698994 3.97928948680873e-07 yes 82 2.23213381960778e-20 18 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1350 1495-0454 146 µM 9.10176755092825 4.89493878536096e-07 yes 83 4.44367417385646e-20 1 1069057 SGTC_515 4092-1064 102 µM 9.07525740226031 5.2674384745398e-07 yes 84 5.67045612651751e-20 13 717353 SGTC_2778 tioconazole 65.09 nM 9.02710873352171 6.01487825388017e-07 yes 85 8.81336220568275e-20 16 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_201 4262-0159 12.803 µM 8.9170168102506 8.12658300505051e-07 yes 86 2.39508501140324e-19 7 1341029 SGTC_3284 9108171 64.8615 µM 8.90251036975593 8.45307998845469e-07 yes 87 2.72987871286343e-19 2 8687505 SGTC_2741 miltefosine 3.04 µM 8.83914197665432 1.00331342446241e-06 yes 88 4.8228241389164e-19 8 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2445 5742597 35.57 µM 8.82568179828178 1.04035214589014e-06 yes 89 5.43974775856892e-19 4 1774255 SGTC_2650 prasterone 100 µM 8.78869460417981 1.14901745955784e-06 yes 90 7.56538801629512e-19 5 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2887 9044784 58.44 µM 8.75675708715909 1.25154247551561e-06 yes 91 1.00474038669686e-18 6 6465546 SGTC_2620 irigenin 100 µM 8.73967092103158 1.3099410230047e-06 yes 92 1.168952132978e-18 7 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2271 7849410 118.62 µM 8.67334127658883 1.56241709686517e-06 yes 93 2.09810954238878e-18 1 972430 SGTC_24 0417-1663 219 µM 8.64356034912815 1.69038980127966e-06 yes 94 2.72439603522555e-18 2 4329390 SGTC_981 1488-1094 54.9 µM 8.59718045771227 1.90991447489482e-06 yes 95 4.08492334356081e-18 2 3449522 SGTC_2163 5671233 125 µM 8.58752982671065 1.95890841018689e-06 yes 96 4.44295292038322e-18 2 701023 SGTC_581 0958-0271 211 µM 8.50010772161713 2.46113440963005e-06 yes 97 9.47074204723398e-18 6 4591145 SGTC_2523 spermine 47.74 µM 8.45794886922003 2.74534740478378e-06 yes 98 1.36060688197561e-17 5 1103 A DNA binding polyamine. SGTC_2699 st077704 54.6 µM 8.36930658887934 3.44882663063157e-06 yes 99 2.89791365842069e-17 9 645852 SGTC_3018 9082602 49.47 µM 8.34389809793584 3.68036194031999e-06 yes 100 3.59404679100333e-17 17 17332089 SGTC_2003 4023581 200 µM 8.31354674184168 3.97644109433631e-06 yes 101 4.64417061683661e-17 6 16641307 SGTC_505 gw-5074 63.9 µM 8.24443073315043 4.73796661376806e-06 yes 102 8.2974177013717e-17 18 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_176 1486-1328 72.834 µM 8.23477104471802 4.85490042434811e-06 yes 103 8.99506808091338e-17 11 22310231 SGTC_1166 k206-0078 225 µM 8.21467664489103 5.10704320307284e-06 yes 104 1.06368361828249e-16 2 5404595 SGTC_2387 9077560 195.08 µM 8.16885953319615 5.72954584613172e-06 yes 105 1.55659189791025e-16 1 5303272 SGTC_205 1486-1330 71.903 µM 8.14194395575378 6.12834228131399e-06 yes 106 1.94490654604355e-16 2 4118834 SGTC_2396 5342950 42.78 µM 8.10690553213695 6.68729972050279e-06 yes 107 2.59625999389008e-16 4 1886677 SGTC_2437 5741531 144.16 µM 8.07844568382814 7.17677906717309e-06 yes 108 3.27987398592102e-16 3 2262990 SGTC_767 0929-0023 86 µM 8.06407115913279 7.43681199865813e-06 yes 109 3.68973840166555e-16 9 1204563 SGTC_1372 2752-0194 270 µM 7.92036224185456 1.05807654963771e-05 yes 110 1.18409811766993e-15 1 823334 SGTC_1496 4469-0713 57.4 µM 7.9075272147436 1.0916151350647e-05 yes 111 1.31275875306628e-15 4 746691 SGTC_1219 1469-0211 33.1 µM 7.90463532787614 1.09931024563883e-05 yes 112 1.3435955272283e-15 6 6822282 SGTC_874 0599-0792 117 µM 7.89752770237845 1.11844314349224e-05 yes 113 1.42244895818638e-15 1 765305 SGTC_823 0417-1665 178 µM 7.8572738960728 1.23292393360303e-05 yes 114 1.9629189244695e-15 9 3429856 SGTC_194 1486-1323 56.904 µM 7.83474076498375 1.30178751731534e-05 yes 115 2.34905502647372e-15 2 5178754 SGTC_621 3584-0052 32.1 µM 7.82621564893642 1.32878273159072e-05 yes 116 2.51387316368307e-15 2 2273927 SGTC_1335 1486-0900 202 µM 7.81746063984814 1.35705952740686e-05 yes 117 2.69497872679315e-15 6 X1335 SGTC_14 0354-0009 295 µM 7.79624750597127 1.42796511254916e-05 yes 118 3.188762066047e-15 3 1713507 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 7.78153209551254 1.47920582223057e-05 yes 119 3.58257234230394e-15 6 6728940 SGTC_2377 9073351 62.6 µM 7.71399084900247 1.73764584143771e-05 yes 120 6.09716107426694e-15 3 7337946 YHR072W ERG7 SGTC_1002 4049-0206 172 µM 7.70512258093068 1.77460537450972e-05 yes 121 6.53588769964244e-15 2 4662749 SGTC_161 4065-0411 162.148 µM 7.7005191297309 1.79408391487604e-05 yes 122 6.77572747250908e-15 18 1906281 YLR208W SEC13 SGTC_3334 9142812 21.919 µM 7.69711116482983 1.80863460032229e-05 yes 123 6.958840579826e-15 1 45283678 SGTC_2165 5727197 32.143 µM 7.69028831352473 1.83810292738291e-05 yes 124 7.34019163606822e-15 3 1361712 SGTC_1159 4092-0538 61.2 µM 7.64516515779706 2.04477660733325e-05 yes 125 1.04338653225572e-14 3 717301 SGTC_523 1934-0222 13.7 µM 7.60775956597995 2.23263216972932e-05 yes 126 1.39444015778299e-14 6 1361595 SGTC_526 4469-0568 170 µM 7.55570100281162 2.52147642422906e-05 yes 127 2.08304947593497e-14 9 2901964 SGTC_912 3474-0017 2.18 µM 7.48871062942831 2.94549028801828e-05 yes 128 3.47767487432128e-14 1 3360550 SGTC_1058 3448-5425 97.3 µM 7.4803178007259 3.00314100975593e-05 yes 129 3.70715474979941e-14 10 7279705 SGTC_1752 st044819 83.042 µM 7.45389665631957 3.19168487552284e-05 yes 130 4.53114965766321e-14 4 441209 YML126C ERG13 SGTC_1455 4262-0120 131 µM 7.42310490508088 3.42555158024046e-05 yes 131 5.72030440249183e-14 7 1529587 SGTC_768 0384-0033 77.3 µM 7.37205955380256 3.84932588257202e-05 yes 132 8.40059632850774e-14 25 3965305 YMR134W ERG29 SGTC_596 1155-0152 116 µM 7.3399040291446 4.14123215226764e-05 yes 133 1.06873533563202e-13 4 280313 SGTC_3342 9147791 14.508 µM 7.31852879023708 4.34671984323419e-05 yes 134 1.25352119957965e-13 1 1838168 SGTC_727 3032-0951 202 µM 7.18834942317258 5.82158684902634e-05 yes 135 3.27896279826176e-13 3 3652836 SGTC_820 1582-0060 59.9 µM 7.17469730975344 6.00104842518587e-05 yes 136 3.6233669406676e-13 3 3848840 SGTC_2409 alverine citrate 63.97 µM 7.15897635405298 6.21416487127742e-05 yes 137 4.06408517403108e-13 14 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1717 st033143 58.0435 µM 7.11259318565931 6.88528098978874e-05 yes 138 5.69412960560866e-13 7 674616 SGTC_1475 4092-1048 11.7 µM 7.10815498524795 6.95295778807212e-05 yes 139 5.88022278501086e-13 5 2881759 SGTC_1263 0774-1208 64.8 µM 7.0032345318069 8.74762099314898e-05 yes 140 1.2505980328861e-12 2 906585 SGTC_1937 st074714 47.2 µM 6.99420131379186 8.92097924739412e-05 yes 141 1.33387134421118e-12 10 17250970 SGTC_2010 4012422 159 µM 6.98501947507786 9.10049672432566e-05 yes 142 1.42408234912627e-12 3 952393 SGTC_1720 st037298 9.481 µM 6.98341082925489 9.13229548948926e-05 yes 143 1.44049167476702e-12 8 597396 SGTC_2197 6588183 93.1375 µM 6.95473209619928 9.71703062007732e-05 yes 144 1.76616324840018e-12 8 884136 SGTC_1435 4092-0789 56.7 µM 6.94112649145056 0.000100065785667671 yes 145 1.94492756328072e-12 5 2248285 SGTC_2175 5807670 165.306 µM 6.92203614506802 0.000104265390542606 yes 146 2.22598804188943e-12 5 241186 SGTC_2198 6589944 200 µM 6.91933373835144 0.000104873086243719 yes 147 2.26886349930373e-12 5 5290268 SGTC_1764 st044502 93.5 µM 6.91569416602131 0.000105696782296842 yes 148 2.327889319912e-12 5 8407 SGTC_1868 st057644 42.7 µM 6.90181402897077 0.000108894188112963 yes 149 2.56713115885622e-12 5 688665 SGTC_834 0312-0008 75.7 µM 6.83332609645771 0.000126044511643483 yes 150 4.14840302149767e-12 12 6385573 YIL048W NEO1 SGTC_474 dl-dihydrosphingosine 5 µM 6.83046082437939 0.000126814486314181 yes 151 4.23211460755099e-12 6 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2024 5144227 134 µM 6.83015296868118 0.000126897477230367 yes 152 4.24120676746714e-12 8 3475211 SGTC_2428 5615643 7.78 µM 6.81063987473313 0.000132262924197421 yes 153 4.85827935091242e-12 6 2253075 SGTC_2034 5197015 53.07 µM 6.76191419195484 0.000146603936392898 yes 154 6.80901778292611e-12 5 780676 SGTC_208 k072-0098 12.366 µM 6.75920423371715 0.00014744281576478 yes 155 6.93758463921258e-12 9 5948901 SGTC_1313 1220-0047 237 µM 6.72566744895466 0.000158203310657966 yes 156 8.73946763438053e-12 13 3528706 SGTC_1284 0929-0043 16 µM 6.72231401974109 0.000159318789734834 yes 157 8.94304804581633e-12 6 1239883 SGTC_1655 st012546 55.1 µM 6.70932611758357 0.000163708914208099 yes 158 9.77626266910624e-12 4 720985 YLR208W SEC13 SGTC_860 0443-0016 25.1 µM 6.69224186359857 0.000169656201898654 yes 159 1.0988860835459e-11 6 5337942 SGTC_1282 0886-0010 32.4 µM 6.67870045107922 0.000174513138764337 yes 160 1.20535164883956e-11 6 2836211 YNL267W PIK1 SGTC_1072 oxiconazole 14.9 nM 6.66254927793023 0.000180476148821299 yes 161 1.34559019371243e-11 17 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1161 k007-0610 110 µM 6.5606238815707 0.000222726294849917 yes 162 2.67915590123095e-11 46 5843850 SGTC_1865 st057639 52.2 µM 6.55986961566249 0.000223070839306203 yes 163 2.69274230371323e-11 3 688818 SGTC_1003 4049-0218 100 µM 6.52374676076221 0.000240166136169401 yes 164 3.42862245047794e-11 1 295161 SGTC_2164 5685496 200 µM 6.52085600257604 0.00024158572094001 yes 165 3.49536369448276e-11 3 759046 SGTC_1047 2043-3044 82 µM 6.42112712745468 0.000295631158737395 yes 166 6.7634500117901e-11 8 669592 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 6.39909703305989 0.000308998010855775 yes 167 7.81492481172086e-11 7 23665772 A membrane-active detergent. SGTC_337 1315-0038 354 µM 6.39862954963942 0.000309287658170334 yes 168 7.83888469130781e-11 9 1626437 SGTC_2385 9074692 200 µM 6.37057430117775 0.000327140183055672 yes 169 9.41608407404027e-11 8 17046906 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 6.36096357829497 0.000333473002642616 yes 170 1.00245993016992e-10 4 688801 SGTC_1706 st031321 9.9705 µM 6.32374059490663 0.00035909159521466 yes 171 1.27653091883543e-10 3 6103185 SGTC_677 0929-0063 136 µM 6.27434945107502 0.000395912010841671 yes 172 1.75549580512159e-10 4 1539583 SGTC_2032 5185112 25.99 µM 6.26807731521015 0.000400830758720972 yes 173 1.82766645977144e-10 3 5718189 SGTC_1181 1222-0449 220 µM 6.25097037469272 0.000414536154292966 yes 174 2.03955127367115e-10 4 658318 SGTC_1382 3002-2117 298 µM 6.24380483611972 0.000420405052144505 yes 175 2.13526397738105e-10 1 1497314 SGTC_1672 st016598 6.51 µM 6.22795663232978 0.000433660208757708 yes 176 2.36278912034765e-10 30 4665860 YNL267W PIK1 SGTC_636 0kpi-0074 126 µM 6.2140403658879 0.000445617990899516 yes 177 2.5819626598714e-10 6 616434 SGTC_1933 st074711 15.9 µM 6.21299468548684 0.000446528743077638 yes 178 2.5992104127e-10 10 17250958 SGTC_33 0986-0033 35.816 µM 6.18800065440497 0.000468817912277235 yes 179 3.04660378414228e-10 6 2848082 SGTC_2231 micatex 6.853 µM 6.15435915257969 0.000500447906828851 yes 180 3.76908410412371e-10 6 20737 An antifungal of unknown mechanism. SGTC_3317 9138495 8.753 µM 6.14590351548206 0.000508702864566043 yes 181 3.975480322973e-10 13 17020139 SGTC_2616 abietic acid 100 µM 6.13110230422971 0.00052345686894492 yes 182 4.36361300078319e-10 10 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 6.09967035795715 0.000556110830389926 yes 183 5.31437140781634e-10 11 6710655 SGTC_638 3970-0837 4.09 µM 6.08941277492264 0.000567168315669332 yes 184 5.66627935738694e-10 13 4118451 YLR208W SEC13 SGTC_2447 5741742 33.78 µM 6.06261120658547 0.000597026350060804 yes 185 6.69645717625951e-10 4 1776504 SGTC_556 4058-0063 51.5 µM 6.06109131503485 0.000598762325539473 yes 186 6.7600521518664e-10 9 6615692 SGTC_2353 9059630 146.67 µM 6.04355350012346 0.000619133670388185 yes 187 7.53781769119283e-10 1 4779114 SGTC_2833 9001315 45.46 µM 5.99795469887001 0.000675132581102967 yes 188 9.99091210156411e-10 18 2989378 SGTC_844 0330-0132 15.3 µM 5.96794602839792 0.000714496305703352 yes 189 1.2012940447221e-09 3 2828079 SGTC_178 4092-0806 87.505 µM 5.95629227571276 0.000730345384694113 yes 190 1.2901235305187e-09 39 2169044 SGTC_1847 st056231 15 µM 5.94953209388201 0.000739687070149109 yes 191 1.34455056156531e-09 6 5393180 SGTC_167 3672-0051 66.205 µM 5.93481177491718 0.000760410721023919 yes 192 1.47091399936303e-09 15 3237971 SGTC_285 1486-1325 46 µM 5.9227515352782 0.000777786594358768 yes 193 1.5829950598083e-09 9 22310230 SGTC_1361 1608-0041 5.61 µM 5.91238565707552 0.000793012706252546 yes 194 1.6859395615309e-09 5 X1361 SGTC_1104 tacrolimus 29.8 µM 5.9072941986204 0.00080059145332395 yes 195 1.73886183423967e-09 14 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1130 3454-2858 15.9 µM 5.89268229623767 0.000822713368924275 yes 196 1.89988267921594e-09 44 715628 YIL048W NEO1 SGTC_1421 4029-0249 71.4 µM 5.88866685886698 0.000828890376476668 yes 197 1.94661671563226e-09 2 2894095 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 5.86283369902754 0.000869661172723484 yes 198 2.27516951443344e-09 7 2333 A French combination drug. SGTC_673 1082-0474 110 µM 5.83893107080938 0.000909019508654398 yes 199 2.62683991109965e-09 23 3098046 SGTC_2148 5546263 113.568 µM 5.79068268984802 0.000993497010846631 yes 200 3.50504511439408e-09 4 792097 SGTC_1393 3470-5649 58.2 µM 5.76833154183717 0.00103502348655898 no 201 4.00300927631897e-09 3 4108395 SGTC_1671 st016596 74.5 µM 5.73976864342601 0.00109040765287363 no 202 4.74029897808091e-09 8 2829167 SGTC_1457 k015-0032 57.3 µM 5.71233417027106 0.00114614878152119 no 203 5.57184941272936e-09 10 4302660 SGTC_3318 9139014 38.6185 µM 5.6937573956552 0.00118536218129786 no 204 6.21368172399656e-09 5 16643984 SGTC_1019 4262-0212 3.4 µM 5.68928381180719 0.00119498711078345 no 205 6.37866431073968e-09 27 4677213 SGTC_1411 3909-8223 150 µM 5.6734620705358 0.00122960442224314 no 206 6.99700482104773e-09 2 X1411 SGTC_583 1488-1091 88.9 µM 5.62652077369532 0.00133778011866895 no 207 9.19403257083398e-09 8 4303273 SGTC_17 0960-0276 49.807 µM 5.60789483288531 0.00138306261159695 no 208 1.02401202158206e-08 7 6821114 SGTC_1835 st008666 49.2 µM 5.58398156204789 0.00144325133229045 no 209 1.17536819146413e-08 9 690455 SGTC_943 3253-1379 105 µM 5.5826893055744 0.00144657099008104 no 210 1.18413801707603e-08 8 668464 SGTC_113 0099-0221 2.5 µM 5.56938270979563 0.00148116175675286 no 211 1.27821705583567e-08 6 89219 SGTC_1076 itraconazole 331 nM 5.54349563146447 0.00155062668063283 no 212 1.48246037234391e-08 12 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2581 avocatin a 64 µM 5.54266257101578 0.00155291064572933 no 213 1.48953299266804e-08 25 6710728 A skin care supplement. SGTC_18 0111-0177 500 nM 5.51536869035586 0.00162945889989772 no 214 1.74024764747427e-08 26 721752 SGTC_926 2268-1401 59.4 µM 5.43817472092032 0.00186493329416786 no 215 2.69145872865198e-08 12 2931578 SGTC_2255 7941087 197.44 µM 5.41611089472086 0.00193770420653345 no 216 3.04546661820839e-08 13 935561 SGTC_933 2914-0560 114 µM 5.40259962288373 0.00198353099552455 no 217 3.28409782585597e-08 13 463887 SGTC_2273 7815444 169.05 µM 5.36469324052879 0.00211740149805434 no 218 4.05434538723681e-08 3 2824616 SGTC_1921 5740136 50 µM 5.35601887732445 0.00214916570685154 no 219 4.25378121844633e-08 25 1774243 SGTC_110 0850-0284 111.64 µM 5.34852091289517 0.00217696960341595 no 220 4.43379655151035e-08 9 3906265 SGTC_1972 st070201 17.4 µM 5.27549427525889 0.00246531697975493 no 221 6.61993723583337e-08 12 2829099 SGTC_755 1995-0008 37.3 µM 5.25386259574116 0.00255712906351756 no 222 7.44710076557056e-08 9 689533 SGTC_1733 st037357 54.9 µM 5.24653229847082 0.002588935424111 no 223 7.74943439429906e-08 8 1272339 YGL099W LSG1 SGTC_2688 kanamycin b 96.69 µM 5.21430555571563 0.00273305076921249 no 224 9.22535617968367e-08 227 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_465 cgp-37157 41 µM 5.17774143380882 0.00290530129469259 no 225 1.12294101022478e-07 6 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2733 amorolfine 100 µM 5.17766191306579 0.00290568634296447 no 226 1.12341961622924e-07 10 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2684 capsaicin 100 µM 5.16616345695317 0.00296184985926902 no 227 1.19473922626996e-07 9 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1953 st076800 12.1 µM 5.15824305061714 0.00300110369783678 no 228 1.24638949770852e-07 22 297591 SGTC_1158 4092-0494 91.8 µM 5.1550958051311 0.00301683125925799 no 229 1.26750643654398e-07 5 1148199 SGTC_779 1360-0071 233 µM 5.14527584525041 0.00306638243684211 no 230 1.33563998259383e-07 11 7566 SGTC_1366 1683-0113 21.9 µM 5.12196363788771 0.00318696281133482 no 231 1.51185104156534e-07 3 708623 SGTC_1709 st033179 39.1045 µM 5.12056705294638 0.00319432019418343 no 232 1.5230913887e-07 3 573381 SGTC_308 4092-1169 104 µM 5.12035254806788 0.00319545158552442 no 233 1.52482495387799e-07 28 2268590 YDL196W YDL196W SGTC_1026 k007-1105 30.6 µM 5.11924729340781 0.00320128689330716 no 234 1.53378753768627e-07 58 7066794 SGTC_2776 terbinafine 19.92 µM 5.11532583081091 0.00322206810470362 no 235 1.5659991517322e-07 32 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1474 0330-0125 5.35 µM 5.08810584964619 0.00336969278757995 no 236 1.80828753079241e-07 10 X1474 SGTC_1402 3909-7673 35.9 µM 5.08143531247581 0.00340678484751073 no 237 1.87296789458713e-07 8 5328014 SGTC_2588 indole-3-carbinol 100 µM 5.06700226369491 0.00348829948114159 no 238 2.02064739464497e-07 18 3712 Induces cell cycle arrest. SGTC_1011 4112-3381 17.4 µM 5.04562195395146 0.00361227187093289 no 239 2.2602422247317e-07 17 2877139 SGTC_2261 9010538 184.68 µM 5.03263428096107 0.00368949685680753 no 240 2.41892754682772e-07 6 6457250 SGTC_729 4092-0585 94.1 µM 5.01804893250133 0.0037779844522674 no 241 2.60994416931996e-07 9 2169061 SGTC_609 0986-0026 86.3 µM 5.01466831605266 0.00379876394401702 no 242 2.65625147666957e-07 9 2848610 SGTC_676 falcarinol 140 µM 5.00651201342924 0.00384932034756243 no 243 2.77126020139708e-07 29 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_23 0213-0011 39.996 µM 5.00205839000901 0.00387717967551952 no 244 2.83607019504088e-07 12 627608 SGTC_2974 9094440 9.66 µM 4.99595452332949 0.00391565546382513 no 245 2.92727285241326e-07 21 25236134 SGTC_2094 5332512 191.667 µM 4.98248372406053 0.00400178170760806 no 246 3.13866360974284e-07 9 755774 SGTC_1171 0368-0077 21.4 µM 4.98068861942267 0.0040133859741642 no 247 3.16792073774997e-07 9 3239779 SGTC_2379 9035213 200 µM 4.97528849027852 0.00404847640565517 no 248 3.25752687868309e-07 3 646551 SGTC_1237 0330-0133 46.1 µM 4.96974482714246 0.00408478498552214 no 249 3.35205355051971e-07 11 X1237 YHR072W ERG7 SGTC_2015 5119600 184 µM 4.93613683034648 0.00431120856120453 no 250 3.98426055246685e-07 14 2828786 SGTC_2233 sulbentine 40.3845 µM 4.92952320500903 0.00435706478313515 no 251 4.12152723421509e-07 35 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2102 5377816 72.7585 µM 4.91672134055861 0.00444706796580318 no 252 4.40028415597298e-07 7 1379702 SGTC_507 nimesulide 162 µM 4.89727959875545 0.00458693029761296 no 253 4.85862639162905e-07 11 4495 A COX2 inhibitor. SGTC_1654 st012436 41.8 µM 4.836032496505 0.00505355512508282 no 254 6.62281383882548e-07 7 4323132 SGTC_1279 0874-0590 65.2 µM 4.83406608083155 0.00506921311379217 no 255 6.68860742385765e-07 18 3523074 SGTC_409 arachidonic acid 100 µM 4.83293141247615 0.00507826778462686 no 256 6.72685742770243e-07 12 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2403 6032726 181.2 µM 4.82879980188585 0.00511135990070758 no 257 6.86792077376286e-07 19 2881040 SGTC_2213 7173844 200 µM 4.79801743747912 0.00536401390434567 no 258 8.01219156965558e-07 6 892728 SGTC_2878 9043973 25.97 µM 4.78195258146624 0.00550023049939663 no 259 8.68003175944497e-07 6 6465167 SGTC_38 0929-0051 58.268 µM 4.76953064899568 0.00560765634151537 no 260 9.23278240753997e-07 10 1379719 SGTC_658 3253-0951 102 µM 4.76406614107462 0.00565550109575933 no 261 9.48651343293845e-07 37 1184878 SGTC_320 4092-0846 5.34 µM 4.7359555804882 0.00590739751475241 no 262 1.09012670586206e-06 30 1359356 SGTC_1381 2324-0066 62.1 µM 4.72173410643193 0.00603858610936411 no 263 1.16921131956774e-06 18 10885928 SGTC_87 0100-0052 35.5 µM 4.71902489316713 0.00606386853290416 no 264 1.18488911655567e-06 64 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1172 0370-0043 85 µM 4.71656077323444 0.00608694515925714 no 265 1.19932370804613e-06 7 376585 SGTC_807 1315-0151 48 µM 4.70765194066964 0.00617102750857885 no 266 1.25293245221934e-06 14 4011080 SGTC_813 k007-0158 173 µM 4.66134553469975 0.00662485618973056 no 267 1.57074397428563e-06 22 6523916 SGTC_278 4092-0821 23.9 µM 4.64213832739189 0.00682159455844649 no 268 1.72410937895801e-06 29 877900 SGTC_1772 st048439 82.2 µM 4.62704841094523 0.00697976176015678 no 269 1.85456918837764e-06 21 2927068 YDL195W SEC31 SGTC_2174 5790901 200 µM 4.61469407179932 0.00711165684447347 no 270 1.96837382765402e-06 27 786020 SGTC_710 3448-4187 58 µM 4.58849604266574 0.0073986443970219 no 271 2.23225384739199e-06 35 3946412 SGTC_410 α-linolenic acid 100 µM 4.58703570050121 0.00741493794709849 no 272 2.24791912627918e-06 22 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2180 6301957 200 µM 4.57573117558064 0.00754213985300811 no 273 2.3727980221974e-06 2 845462 SGTC_3348 9149464 3.537 µM 4.55934126701229 0.00772997668905321 no 274 2.56571628239985e-06 7 1951442 SGTC_1193 1488-0126 41.5 µM 4.55377313729053 0.00779472082270402 no 275 2.63460896756231e-06 17 1384710 SGTC_1975 st070967 30.8 µM 4.51659846380004 0.00823932998881551 no 276 3.14204518729168e-06 24 261391 SGTC_3067 9117431 49.47 µM 4.51294976001724 0.00828414638095547 no 277 3.19660852095396e-06 2 17150885 SGTC_3324 9138759 60.749 µM 4.51229682669942 0.00829218879109779 no 278 3.20646774632994e-06 10 45595710 SGTC_1991 st073000 8.92 µM 4.50260230714345 0.00841240884360679 no 279 3.35632116406748e-06 61 4301969 YIL048W NEO1 SGTC_2874 9043904 71.43 µM 4.45721728436033 0.00899579379012575 no 280 4.15152162218984e-06 4 4463428 SGTC_2518 prenyletin 46.28 µM 4.45382726919604 0.00904075886915455 no 281 4.21764855152877e-06 6 3873459 A coumarin with calcium channel inhibitory activity. SGTC_737 1950-0117 57.9 µM 4.44937743883042 0.00910008000327757 no 282 4.30597784178097e-06 16 5393513 SGTC_1420 4'-methoxyflavone 42 µM 4.4178604742587 0.00953007680394318 no 283 4.9841366421925e-06 6 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2372 9071633 200 µM 4.39205297943406 0.00989530147641124 no 284 5.61426638611767e-06 8 21321366 SGTC_517 1365-0151 113 µM 4.38415511969875 0.0100094866054247 no 285 5.82183930588664e-06 27 768657 SGTC_1173 0443-0020 122 µM 4.36797542938589 0.010247004511354 no 286 6.27017986239452e-06 25 5331295 SGTC_738 1315-0003 72.4 µM 4.36489025223398 0.0102928487433478 no 287 6.35932986666804e-06 14 6251474 SGTC_2931 9014674 55.67 µM 4.36434037081347 0.010301038465877 no 288 6.37534583459942e-06 14 2996810 SGTC_1854 st056233 32.9 µM 4.35732522253138 0.0104060190747652 no 289 6.5830779782964e-06 13 5393174 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 4.35138419423634 0.0104956537459984 no 290 6.76403837544225e-06 39 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 4.34675568101938 0.0105659515136432 no 291 6.90829863863867e-06 7 7104 SGTC_826 1683-5028 118 µM 4.3432013691665 0.0106202124324516 no 292 7.02106563569264e-06 9 722377 SGTC_1259 0671-0132 43 µM 4.33851465025747 0.0106921318601576 no 293 7.1724462014904e-06 16 X1259 SGTC_2210 7115885 190.385 µM 4.33365286583349 0.0107671855516203 no 294 7.33276814084089e-06 26 2927039 SGTC_2203 7227154 166.4 µM 4.32793924352635 0.0108559753734582 no 295 7.52554862329914e-06 6 896304 SGTC_2081 5214970 32.255 µM 4.31167495221903 0.0111122204933634 no 296 8.10112502501089e-06 17 2063512 SGTC_974 1326-0144 138 µM 4.26625697683848 0.0118558253650921 no 297 9.93899024713569e-06 31 5411856 SGTC_2455 5377712 9.75 µM 4.2442251288699 0.0122318363742712 no 298 1.09675027001835e-05 17 2243908 SGTC_682 0kpi-0099 17 µM 4.23391774030625 0.0124112692737227 no 299 1.14827488795929e-05 59 1714895 YML126C ERG13 SGTC_601 0986-0029 62.9 µM 4.23348583649291 0.0124188374396836 no 300 1.15048340060269e-05 28 24747981 SGTC_495 decylubiquinone 155 µM 4.22971420103403 0.0124850970873373 no 301 1.16994194568051e-05 18 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2701 st077767 14.721 µM 4.21117037116437 0.012815343635289 no 302 1.27025525369581e-05 39 5721188 SGTC_2381 9035592 200 µM 4.20004804846389 0.01301702446803 no 303 1.33429171777921e-05 14 4749657 SGTC_152 4469-0003 551.229 µM 4.19548614353468 0.0131005355340016 no 304 1.36143466745459e-05 20 697280 SGTC_1117 retinoic acid 1.10837 µM 4.17603967646449 0.0134617406692043 no 305 1.48314051758975e-05 12 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2910 7948405 25.97 µM 4.1312293613528 0.0143269395338621 no 306 1.80414166819197e-05 23 2971328 SGTC_696 1560-0013 611 µM 4.12932894967907 0.0143646678145996 no 307 1.81911778815758e-05 18 1650269 SGTC_2284 7945075 39.21 µM 4.12661305044659 0.0144187341953 no 308 1.84072533577498e-05 22 1245402 SGTC_2395 5646831 180.19 µM 4.11935049252912 0.0145641739931915 no 309 1.89970925465195e-05 18 6808628 SGTC_975 1335-0046 28.5 µM 4.10168770482312 0.0149231673686039 no 310 2.0507379663108e-05 31 16486740 SGTC_1819 st053448 58.6 µM 4.09858754175754 0.01498695628284 no 311 2.07839510044541e-05 16 2857616 SGTC_258 haloperidol 50.781 µM 4.09704891573942 0.015018701963833 no 312 2.09225252549619e-05 26 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1337 1486-1011 40.3 µM 4.09368272353843 0.0150883564772417 no 313 2.12287597302968e-05 13 X1337 SGTC_1509 1326-1131 80 µM 4.07898945047418 0.0153956549547951 no 314 2.26159445993266e-05 11 768313 SGTC_1157 4092-0394 27.6 µM 4.07738794473865 0.0154294717471597 no 315 2.27722335340867e-05 29 3659885 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 4.07334812487331 0.0155150585043053 no 316 2.31710376793278e-05 33 4174840 SGTC_2468 5987765 72.9 µM 4.06976843507198 0.0155912372368356 no 317 2.35299445987046e-05 12 26772094 SGTC_1320 1313-0481 95.3 µM 4.06554937513755 0.0156814341710509 no 318 2.39597237218462e-05 18 6813365 YLR208W SEC13 SGTC_251 melphalan 456.522 µM 4.06187423192337 0.0157603674661373 no 319 2.43401513838443e-05 19 460612 A DNA alkylator. SGTC_2312 7706453 155.7 µM 4.05597743958785 0.0158877285246277 no 320 2.49625392679623e-05 27 976098 SGTC_1436 4092-1007 8.32 µM 4.04611792090529 0.016102649423003 no 321 2.60370042688716e-05 10 2881121 SGTC_668 1682-0499 62.6 µM 4.04391444068232 0.0161510207478576 no 322 2.62830543780751e-05 19 682214 SGTC_2355 9061122 103.12 µM 4.04027536038087 0.0162311793043759 no 323 2.66942404661992e-05 13 5302957 SGTC_2182 6325192 200 µM 4.03221263354069 0.0164099929375066 no 324 2.7627079311399e-05 14 736248 SGTC_1410 3909-8106 77.9 µM 4.01525192027694 0.0167916565457537 no 325 2.96911658554062e-05 12 1039210 SGTC_384 k007-0144 5.16 µM 4.01345569537314 0.0168325177673773 no 326 2.99181188664875e-05 58 6824886 SGTC_415 dibenzyl ketone 100 µM 4.00516679784418 0.0170221802563956 no 327 3.09868675783937e-05 8 7593 SGTC_2582 agaric acid 100 µM 4.00121483111752 0.0171132484586452 no 328 3.15090551283921e-05 312 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 3.99997159481531 0.0171419832677322 no 329 3.16750435213708e-05 36 688788 SGTC_1674 st016616 23.6 µM 3.98995943771214 0.0173748999802035 no 330 3.30422978039206e-05 26 625830 SGTC_1494 4358-1428 177 µM 3.98935078426857 0.0173891460544817 no 331 3.31271908405351e-05 24 1564571 SGTC_1600 coumarin 106 71.1 µM 3.98081447580805 0.0175899992950206 no 332 3.43397689865132e-05 25 100336 A hepatotoxic, DNA x-linker. SGTC_74 000s-0487 160.283 µM 3.9731714124626 0.0177715120571247 no 333 3.54609861567727e-05 22 677548 SGTC_179 1273-0063 6.77 µM 3.96445077121964 0.0179805653586629 no 334 3.67825628911387e-05 22 3108139 SGTC_2122 5258151 111.688 µM 3.96351643268859 0.0180030874134525 no 335 3.69268886715405e-05 23 2173356 SGTC_614 0462-0418 107 µM 3.95613651472808 0.0181818256969614 no 336 3.80858216439669e-05 28 5188303 SGTC_1705 st027868 56.3335 µM 3.95513364694107 0.0182062310343441 no 337 3.824593977711e-05 8 292948 SGTC_1379 2144-0755 36.5 µM 3.95012266616161 0.0183285946457535 no 338 3.9055575411654e-05 24 5392327 SGTC_639 0833-0042 114 µM 3.94979792716317 0.01833654859399 no 339 3.91085994526979e-05 44 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2158 5657123 3.6195 µM 3.94574532302945 0.0184360580544542 no 340 3.97760673358092e-05 6 2858827 SGTC_2993 9054257 71.4286 µM 3.93950636716197 0.0185901510773588 no 341 4.08247176231315e-05 43 6470217 YGL055W OLE1 SGTC_669 0108-0021 26.2 µM 3.92539953770465 0.0189426157895381 no 342 4.32929508519264e-05 81 17201 SGTC_939 1165-0479 45.3 µM 3.92489919572552 0.0189552207057508 no 343 4.33830319129896e-05 27 1377347 SGTC_862 0452-0056 10.2 µM 3.92126910822916 0.0190468858715536 no 344 4.40419123229286e-05 34 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2721 ifenprodil 61.44 µM 3.91539641261211 0.0191959783958276 no 345 4.51278950417746e-05 18 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2717 st081029 62.2815 µM 3.89687669912518 0.019672659016948 no 346 4.87205980746216e-05 19 5292846 SGTC_2689 tacrolimus 100 µM 3.89479123324565 0.0197269612968775 no 347 4.91416708667333e-05 48 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1901 st060216 58.6 µM 3.88471677707079 0.0199910798358178 no 348 5.12246237010959e-05 24 688792 SGTC_1042 0350-0096 82 µM 3.87653084591886 0.0202078910401821 no 349 5.29781913759221e-05 28 3122515 SGTC_1907 st060210 83.7 µM 3.87457664493948 0.020259943470723 no 350 5.3405111632251e-05 27 688793 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 3.87423280311913 0.0202691138499221 no 351 5.34805633203767e-05 9 4620898 SGTC_1952 st077036 64.1 µM 3.87102164421778 0.020354926576175 no 352 5.4190083637715e-05 38 2937007 SGTC_890 0929-0006 47.2 µM 3.86027510611148 0.0206443524328991 no 353 5.6629719582607e-05 19 1378169 SGTC_563 tetrahydrosecaminediol 614 µM 3.84408586343104 0.0210869378230596 no 354 6.0501318648045e-05 18 334274 A psychoactive constituent of the cannabis plant. SGTC_3255 9139072 49.47 µM 3.83949850661486 0.0212137982613467 no 355 6.16429396854694e-05 17 17646060 SGTC_1759 st043059 70 µM 3.83440221554541 0.0213554892940012 no 356 6.29350161577672e-05 29 669426 SGTC_1765 st044815 90.4 µM 3.82630763271779 0.0215821856947077 no 357 6.50398566718914e-05 29 645695 SGTC_1710 st031758 61.5 µM 3.80441446456476 0.022205535233806 no 358 7.10700082069265e-05 13 5394341 SGTC_2949 9072542 2.23 µM 3.80368237105457 0.0222266394496548 no 359 7.12804761003228e-05 41 16457352 SGTC_312 4092-0653 6.84 µM 3.79006633864548 0.0226222467180284 no 360 7.53035284277328e-05 93 1148278 SGTC_2938 9059746 27.26 µM 3.78259428866538 0.0228418547528735 no 361 7.76011363266023e-05 42 6471769 SGTC_40 0327-0103 19.753 µM 3.77796919556639 0.0229786869708641 no 362 7.90562151410031e-05 37 409036 SGTC_2987 9018338 71.43 µM 3.76917093630128 0.0232408874883325 no 363 8.18953455712099e-05 22 5055682 SGTC_210 3551-0445 56.827 µM 3.75017752514779 0.0238155128747235 no 364 8.83547114311053e-05 69 2865180 YOR207C RET1 SGTC_1840 st055363 71 µM 3.74820334731994 0.0238759189448361 no 365 8.90529156962408e-05 14 676033 SGTC_1213 1315-0166 115 µM 3.73934220154179 0.0241486416644195 no 366 9.22512115170972e-05 35 768401 SGTC_2296 7971656 126.45 µM 3.73929679381759 0.0241500459054366 no 367 9.22678754024027e-05 46 666570 SGTC_733 4069-0007 56.1 µM 3.72782265496858 0.0245070907001387 no 368 9.6570603768832e-05 93 5717425 YNL287W SEC21 SGTC_763 3453-1109 128 µM 3.7268125667532 0.0245387330594103 no 369 9.69582766738354e-05 22 1560353 SGTC_2914 7968218 45.32 µM 3.7254107529417 0.0245827035514255 no 370 9.74987179622365e-05 16 2977111 SGTC_332 4112-0506 40.9 µM 3.72262024896817 0.0246704297142196 no 371 9.85829776194076e-05 29 2790355 SGTC_1691 st019933 84.6 µM 3.70326135933496 0.0252862819684516 no 372 0.000106422699887188 18 6176082 SGTC_2658 polymyxin b sulfate 77.05 µM 3.68442140977998 0.0258979413738473 no 373 0.000114611367850805 54 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_3085 9117376 49.47 µM 3.68270281758898 0.0259543483159686 no 374 0.000115387066503734 18 16480349 SGTC_2160 5660466 132.927 µM 3.67547030268835 0.0261928586393941 no 375 0.000118705828853892 26 2859134 SGTC_821 1114-0266 29.2 µM 3.67203895607874 0.0263066553005109 no 376 0.000120311495650051 26 3123235 SGTC_1390 3413-2614 145 µM 3.67151263716152 0.0263241465653502 no 377 0.000120559576692047 31 3421432 SGTC_1184 1269-1718 139 µM 3.6652300314398 0.0265336893428093 no 378 0.000123558183932943 39 5403821 SGTC_1778 st046819 58.9 µM 3.66474436257319 0.0265499456485366 no 379 0.000123792876947259 34 671715 SGTC_2787 5284540 71.43 µM 3.64622352996242 0.0271761122142776 no 380 0.00013306125293227 37 736958 SGTC_3351 9150312 21.596 µM 3.61470326762199 0.0282700851260858 no 381 0.000150345910075947 42 4904905 SGTC_2441 5730946 39.09 µM 3.61452114937965 0.0282765108576482 no 382 0.000150451626705977 29 1774275 SGTC_2669 eugenol 100 µM 3.61060899996579 0.0284148381780833 no 383 0.000152739443885565 16 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_543 3844-1095 191 µM 3.60393918225678 0.028651970336679 no 384 0.00015671521355647 62 4230703 SGTC_2735 sertaconazole 140 nM 3.59947586245793 0.0288115721982987 no 385 0.00015942961369011 21 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_960 1222-0186 7.7 µM 3.59888341723743 0.028832812641722 no 386 0.000159793204211992 42 3126296 SGTC_2683 piperine 63.03 µM 3.59799592060751 0.0288646556719817 no 387 0.00016033932372307 22 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2092 5303694 80.6725 µM 3.59237235899299 0.0290671070128233 no 388 0.000163840584628944 48 1963699 SGTC_1860 st056228 74.6 µM 3.58339859764863 0.0293926100846937 no 389 0.000169576230671926 32 688679 SGTC_2777 climbazole 1.536 µM 3.57652628509085 0.0296439293270069 no 390 0.000174095160145933 70 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2050 5263056 171 µM 3.5759335295998 0.0296656895805224 no 391 0.000174490161317884 59 763468 YGL055W OLE1 SGTC_881 0833-0569 170 µM 3.55691596519842 0.0303708965082781 no 392 0.000187617061794996 47 5418700 SGTC_1088 bifonazole 369 nM 3.55460405579578 0.0304575657331481 no 393 0.000189274343075711 24 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1998 st075797 76.8 µM 3.5488016495934 0.0306759900335094 no 394 0.000193494233475408 25 24208315 SGTC_1165 k072-0275 30.3 µM 3.54292010952842 0.030898715374987 no 395 0.000197861281979956 55 6153523 YGL055W OLE1 SGTC_1135 dihydrocapsaicin 536.708 nM 3.53829703721677 0.0310747224279772 no 396 0.000201358374695235 49 107982 A Capsaicinoid. SGTC_837 0091-0265 12.5 µM 3.53474088769959 0.0312106739312181 no 397 0.000204087600514736 36 759367 SGTC_352 k048-0007 5.11 µM 3.53024108819967 0.0313834058875286 no 398 0.000207590576820125 93 6811911 SGTC_2838 9002687 71.43 µM 3.52026913078234 0.0317690130761234 no 399 0.000215554559366301 33 6457060 SGTC_2598 perillyl alcohol 100 µM 3.50513017365147 0.0323618992733843 no 400 0.000228192038902738 52 10819 An apoptosis inducer. SGTC_1708 st033234 31.827 µM 3.50492370666978 0.0323700478092659 no 401 0.000228369074414677 27 674664 SGTC_1567 st069303 68.4 µM 3.49812371923613 0.0326393672556519 no 402 0.000234271863993291 34 5581319 SGTC_918 glabranin 770.725 nM 3.49420095922336 0.0327955702873766 no 403 0.000237741479842356 50 124049 Also referred to as licorice root. SGTC_2079 5212404 121 µM 3.47564829415244 0.0335427031462066 no 404 0.000254810074299662 20 758462 SGTC_2237 6667747 47.222 µM 3.47473238223488 0.03357994773567 no 405 0.000255681615718551 26 729940 YDL015C TSC13 SGTC_2299 7976368 114.88 µM 3.46211158092029 0.034096634134851 no 406 0.000267977453063898 46 2979718 SGTC_666 0272-0154 136 µM 3.45464030313337 0.0344055709449228 no 407 0.000275513714284351 78 6870312 SGTC_2695 st077686 51.995 µM 3.45252793782612 0.03449333299934 no 408 0.000277679981387058 53 2876092 SGTC_1628 st004252 77.7 µM 3.44597698685845 0.0347666744413318 no 409 0.000284499406554297 36 692968 SGTC_1360 1598-0022 39.8 µM 3.44254901287616 0.0349104155762835 no 410 0.000288129715193939 50 761525 SGTC_2181 6316240 54.2555 µM 3.43663278502217 0.0351596409924308 no 411 0.000294496781559203 37 12779990 SGTC_971 1315-0384 26.7 µM 3.43107119275475 0.0353952564498697 no 412 0.000300601398492118 45 6769120 SGTC_1505 k297-0037 20.6 µM 3.42669191064614 0.0355816934848368 no 413 0.000305490926626246 35 4089396 SGTC_455 paf C-16 10 µM 3.42181958204878 0.0357900660226505 no 414 0.000311017873832966 46 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2829 7992743 58.44 µM 3.42052333981783 0.0358456698710492 no 415 0.000312503861875788 57 16462845 SGTC_2550 chrysin dimethyl ether 71.87 µM 3.41744091676926 0.0359781783712656 no 416 0.000316064064900248 16 88881 An O-methylated flavonoid and antioxidant. SGTC_987 1497-1013 404 µM 3.41428134068233 0.0361144197041802 no 417 0.000319752511621747 22 1676435 SGTC_1912 st060209 90.8 µM 3.41320820069528 0.0361607896434073 no 418 0.00032101436237578 55 688787 SGTC_3285 9112818 20.8695 µM 3.39711658052247 0.0368619664958919 no 419 0.000340499738687061 44 17017947 YPR165W RHO1 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 3.39613929669517 0.0369049063200283 no 420 0.000341717846069479 115 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1594 piperine 70.1 µM 3.37488506027392 0.037848933276252 no 421 0.000369232632013187 29 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 3.35993047521479 0.0385248944821533 no 422 0.000389810445856723 47 688664 SGTC_365 0121-0052 13.6 µM 3.35543751771409 0.0387298916598851 no 423 0.000396197771434484 92 3101739 SGTC_166 k072-0058 166.424 µM 3.35447206166935 0.0387740576684543 no 424 0.000397582911991345 59 5846229 SGTC_1373 2887-0003 58.5 µM 3.33972429476913 0.0394538270190095 no 425 0.000419308001131934 40 776948 SGTC_435 c-PAF 6.7 µM 3.31848220875718 0.0404499461297828 no 426 0.000452540440117095 73 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_294 k038-0071 157 µM 3.31539931436344 0.0405961966078424 no 427 0.000457561502758134 96 24152826 SGTC_2366 9070441 60.58 µM 3.30868218491807 0.0409163393212997 no 428 0.000468680881539007 59 6837235 SGTC_1114 scopoletin 1.73284 µM 3.30114939357208 0.04127778990393 no 429 0.000481447983307003 34 5280460 A coumarin with genotoxic properties. SGTC_2473 5854593 8.94 µM 3.28499592041203 0.0420616197541176 no 430 0.000509919241474998 29 2872951 SGTC_1571 st070080 73.4 µM 3.27541607557099 0.0425321340623046 no 431 0.000527532285523404 41 4315245 SGTC_1131 3454-3128 32.3 µM 3.27337461823303 0.0426329484059003 no 432 0.000531357635362024 73 710982 SGTC_373 0844-0104 25.9 µM 3.27217504602241 0.0426922775629608 no 433 0.000533617386698693 85 5375804 SGTC_3310 9130229 44.1445 µM 3.25933187260871 0.0433316746870603 no 434 0.000558374745266655 54 7761258 SGTC_2118 5526350 200 µM 3.25256867220183 0.0436714756591809 no 435 0.000571834783532349 38 743594 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 3.24698420161751 0.0439536720173351 no 436 0.000583174319304853 49 688761 SGTC_137 0438-0332 85.389 µM 3.24640653639473 0.0439829465312792 no 437 0.000584359079860487 167 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2288 7946289 167.31 µM 3.23967653672408 0.0443251647362031 no 438 0.000598326822830537 64 1246052 SGTC_1548 st061468 90.8 µM 3.2380152824131 0.0444099683484685 no 439 0.000601821808761309 25 390799 SGTC_605 1315-0399 119 µM 3.23672125250604 0.0444761164522731 no 440 0.000604557275473399 58 24020461 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 3.23376955067689 0.0446272983412996 no 441 0.000610839949394234 51 1377 SGTC_1225 1216-0074 20.6 µM 3.2284722523263 0.0448996560846048 no 442 0.000622266659295773 55 4241466 SGTC_2719 novobiocin 32.65 µM 3.22790830040624 0.044928730012251 no 443 0.000623494705385274 11 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1344 1488-0097 29.1 µM 3.22433635869728 0.0451132297295165 no 444 0.000631324986788912 40 747966 SGTC_1271 0832-2808 169 µM 3.20885775051494 0.0459197951800127 no 445 0.000666317029855043 34 3663794 SGTC_386 1509-0011 3.07 µM 3.20781707345547 0.045974436246789 no 446 0.000668732693886639 180 3107280 SGTC_343 4130-2827 29.8 µM 3.19378785100334 0.0467161554935061 no 447 0.000702096338829747 65 1118244 SGTC_298 1391-0729 10 µM 3.18895288807129 0.0469739914413354 no 448 0.000713945732943463 33 3237558 SGTC_651 3253-0966 34.4 µM 3.18150017299915 0.0473736591703184 no 449 0.000732572176937737 69 781462 SGTC_3344 9148862 3.898 µM 3.18095173954209 0.04740317739411 no 450 0.000733960405117203 37 4905352 SGTC_979 1426-2828 121 µM 3.17432873318032 0.0477608109728027 no 451 0.000750917461228659 54 747872 SGTC_2416 tofa 880 nM 3.17379784377952 0.0477895715803676 no 452 0.000752292217431707 90 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1546 5-methoxyflavanone 78.7 µM 3.16447617015872 0.0482968305175527 no 453 0.000776811920198062 32 147795 SGTC_3158 9100007 49.47 µM 3.16053953457269 0.0485123404782673 no 454 0.000787386162223961 44 19297233 SGTC_736 0958-0254 92.6 µM 3.1536815109521 0.0488896170097411 no 455 0.000806124661469794 67 6812352 SGTC_2434 5670830 169.91 µM 3.14170381979064 0.0495541586810146 no 456 0.000839839271853794 59 1549830 SGTC_325 2810-4341 181 µM 3.13391979243876 0.0499898802735034 no 457 0.000862439985240494 25 774970 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 3.13305285005328 0.0500385970615679 no 458 0.000864991445898122 62 6708561 SGTC_473 2-arachidonoylglycerol 10 µM 3.12488305293739 0.0504995504857694 no 459 0.000889378807899938 46 5282280 An endocannabinoid. SGTC_1032 k061-1018 98.7 µM 3.12226983257254 0.050647704717549 no 460 0.000897311858538328 58 4005393 SGTC_1305 1181-0477 144 µM 3.11960181860636 0.0507993223667303 no 461 0.00090547830191689 45 6252086 SGTC_2360 9040895 200 µM 3.11052471634293 0.0513178630426256 no 462 0.000933776328018371 43 4914414 SGTC_1067 clotrimazole 1.36 µM 3.09324124998888 0.0523168372104728 no 463 0.000989915587153691 80 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2422 chlorphenesin carbamate 384.24 µM 3.07684885641541 0.0532785163437393 no 464 0.00104600673667257 83 2724 A muscle relaxant with antifungal properties. SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 3.07548347222424 0.053359246278089 no 465 0.00105080788015795 71 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_891 0929-0073 133 µM 3.06872734057682 0.0537601380771124 no 466 0.00107486347165569 60 5603632 SGTC_334 1502-1024 68.5 µM 3.06870412932291 0.0537615194745077 no 467 0.00107494697994152 39 3296216 SGTC_1986 st071812 45 µM 3.0672772950346 0.053846490254053 no 468 0.00108009180908368 29 11838594 SGTC_530 4358-1714 28 µM 3.06225955417147 0.0541461513766533 no 469 0.0010983644079374 85 1564641 SGTC_1900 st060200 72.8 µM 3.0588130089432 0.0543527436703743 no 470 0.00111107902228319 57 688945 SGTC_2896 9052656 71.43 µM 3.05770926244532 0.054419035943462 no 471 0.00111517926791755 199 6469436 SGTC_2528 xanthyletin 44.79 µM 3.05250836437054 0.0547322689269621 no 472 0.00113468703161693 50 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2080 5212524 12.4 µM 3.04716167388048 0.055055766591991 no 473 0.00115506710404074 45 260183 SGTC_68 0986-0284 82.829 µM 3.0466695236937 0.0550856195545283 no 474 0.00115695979223763 126 423278 YIL048W NEO1 SGTC_1252 0493-0875 34.8 µM 3.03496807141445 0.05579918285294 no 475 0.00120280576106031 74 3960963 SGTC_1336 1486-0901 104 µM 3.02614370821835 0.0563421074559907 no 476 0.00123847273783392 53 5006114 SGTC_1970 st070122 35.8 µM 3.0209608559471 0.0566629216474118 no 477 0.00125986966226489 70 102928 SGTC_1652 st011932 78 µM 3.01067169042341 0.0573040753026332 no 478 0.00130335266012532 49 1551076 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 3.00900650004105 0.0574083737362844 no 479 0.00131051754109185 83 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1956 st077085 54 µM 3.00241351033435 0.0578227895616245 no 480 0.00133924036021426 58 24208685 SGTC_1156 4092-0367 4.88 µM 2.99642591256737 0.0582011867373283 no 481 0.00136582303499008 70 1357585 SGTC_1469 k284-2957 126 µM 2.99559990028999 0.0582535404468123 no 482 0.00136952781789873 43 23884841 SGTC_1782 st039423 80.636 µM 2.9892765725236 0.0586555475192549 no 483 0.00139819440734713 74 2068169 SGTC_407 eburnamonine 100 µM 2.98679168836258 0.0588141194078827 no 484 0.00140960875176149 53 3195 SGTC_1251 0490-5699 265 µM 2.98460087007342 0.0589542044844985 no 485 0.00141974281467038 86 3883818 SGTC_2268 7933382 153.85 µM 2.97750569750701 0.0594096805705156 no 486 0.00145302121609373 81 935025 YOR257W CDC31 SGTC_1464 k208-0027 110 µM 2.96084471022849 0.0604900800379238 no 487 0.00153398292747444 59 X1464 SGTC_1029 k015-0030 64.7 µM 2.96058999895665 0.0605067155774225 no 488 0.00153525197735794 81 2208316 SGTC_1285 0929-0069 65.5 µM 2.9536079437519 0.0609641184217069 no 489 0.00157041371977761 64 1206237 SGTC_764 1951-2361 146 µM 2.94359180010224 0.0616250030071128 no 490 0.0016221379562503 83 5438930 SGTC_1561 5-methoxyflavone 52.9 µM 2.93768835836889 0.0620171358851059 no 491 0.00165334617052519 25 94525 SGTC_1995 st072814 61.1 µM 2.93606337937932 0.0621254152414636 no 492 0.00166203199682631 55 5769371 SGTC_892 0929-0076 29 µM 2.91750095049296 0.0633727996139377 no 493 0.00176424286669903 106 5751038 SGTC_3019 9081971 49.47 µM 2.91592825145951 0.0634793735921471 no 494 0.00177316021619399 44 16451803 SGTC_279 1273-0055 2.93 µM 2.90895024861445 0.0639539213634671 no 495 0.00181322282634292 92 2847562 SGTC_2495 cafestol 54.53 µM 2.90745196983898 0.0640561725248827 no 496 0.00182193148312792 80 16667697 An anti-infammatory. SGTC_2042 p-Dimethylaminoacetophenone 200 µM 2.89019939327047 0.0652427653917096 no 497 0.00192498772642651 71 75037 A free radical scavenger. SGTC_1570 verbenone 133 µM 2.88950253909367 0.0652910493686923 no 498 0.0019292594546671 64 29025 A natural terpanoid with antifungal properties. SGTC_875 0709-0210 25.7 µM 2.88357043672099 0.0657031989651482 no 499 0.00196597351254587 80 6251364 SGTC_1416 3966-0321 25.3 µM 2.86008370329807 0.0673548323538486 no 500 0.00211764602589377 78 582530 YLR208W SEC13 SGTC_2304 7443016 91.4 µM 2.84596306259783 0.0683631622008798 no 501 0.00221386652815184 59 939854 SGTC_86 0417-1630 471.922 µM 2.84484713342759 0.0684433426898354 no 502 0.00222163706630617 242 3634867 SGTC_1902 st060212 70.5 µM 2.84409722141537 0.0684972652719956 no 503 0.00222687279761957 77 688944 SGTC_368 fentichlor 4.58 µM 2.84244656078016 0.0686160718283154 no 504 0.00223843678368826 84 7329 A pesticide. SGTC_436 n,n-dimethylsphingosine 3.3 µM 2.83727719953581 0.0689891657631508 no 505 0.00227500450768057 80 5282309 SGTC_413 propylparaben 100 µM 2.83714444761726 0.0689987675638732 no 506 0.00227595067198249 75 7175 A pharmaceutical preservative. SGTC_2317 5986382 200 µM 2.83494737052586 0.0691578293691524 no 507 0.0022916617778971 55 877883 SGTC_2316 5844804 197.44 µM 2.83394971362668 0.0692301499545187 no 508 0.0022988283103478 115 776813 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 2.81017076615851 0.0709711943888214 no 509 0.00247576101093827 94 91467 include heat shock SGTC_1517 deoxycholic acid methyl ester 49.2 µM 2.80618846900521 0.0712660292420898 no 510 0.00250656806650227 65 229346 A bile salt which induces apoptosis. SGTC_2062 5245942 200 µM 2.79822155794124 0.0718586915998273 no 511 0.00256924260284806 78 1376160 SGTC_1906 st060206 94.7 µM 2.79481420667299 0.0721133171168244 no 512 0.00259647750035278 84 5133468 SGTC_1838 st055369 84.5 µM 2.79431326312218 0.0721508100124113 no 513 0.00260050345364453 61 676036 SGTC_1339 1486-1321 22.7 µM 2.78611670761378 0.0727664019222843 no 514 0.00266718311062469 90 3469382 SGTC_1770 st043884 66.3 µM 2.76453424448585 0.0744065587157729 no 515 0.00285020617259862 68 670149 SGTC_726 3448-4391 34.2 µM 2.76200828281121 0.0746003494045493 no 516 0.00287235105269977 70 1356692 SGTC_616 4092-0450 108 µM 2.75099761017118 0.0754495852575101 no 517 0.00297070383869719 71 787165 SGTC_2678 equilin 100 µM 2.74458869474246 0.0759472758910142 no 518 0.00302933899235984 79 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_864 0469-0573 172 µM 2.74444914021338 0.0759581408774086 no 519 0.00303062729406344 82 689425 SGTC_1458 k015-0034 6.33 µM 2.74395122205115 0.0759969158282655 no 520 0.00303522786286262 63 3598957 SGTC_2190 6049624 200 µM 2.74207619595573 0.0761430671211859 no 521 0.00305260887188161 38 2265554 SGTC_149 3970-0822 46.1 µM 2.74177018291953 0.076166939990413 no 522 0.00305545402761904 218 3114250 YBL034C STU1 SGTC_3015 9080845 49.47 µM 2.73410467415674 0.0767668066160528 no 523 0.00312750781264678 49 5296973 SGTC_3106 9121286 49.47 µM 2.73154681046808 0.0769677702652676 no 524 0.00315188926402239 64 15943471 SGTC_548 1436-0017 110 µM 2.72231893592153 0.0776961009605468 no 525 0.00324127730285566 113 9677137 SGTC_1485 3909-9022 254 µM 2.72058716955029 0.0778333656783768 no 526 0.00325830440125826 69 714516 SGTC_976 1348-1067 47.6 µM 2.71715992078311 0.0781055615758641 no 527 0.0032922392009552 108 5310671 YGL099W LSG1 SGTC_1821 st053465 65.6 µM 2.6945359953464 0.0799205249858781 no 528 0.00352433563882084 55 675086 SGTC_623 k072-0108 16.9 µM 2.6919154932218 0.080132794251891 no 529 0.00355214720629203 92 5382803 SGTC_2300 7976697 71.57 µM 2.69181879712037 0.0801406350984615 no 530 0.00355317720772259 98 2236109 SGTC_1813 st051246 8.6015 µM 2.68326940678649 0.0808361787007874 no 531 0.00364531166681254 59 5291959 SGTC_462 ag-879 158 µM 2.67798045601604 0.0812687423366775 no 532 0.00370337700100725 113 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1363 1636-0063 10.4 µM 2.6735186058754 0.0816350165620864 no 533 0.0037530056163092 116 6072185 SGTC_501 nsc-95397 161 µM 2.67199947770873 0.0817600057115697 no 534 0.00377003829005637 65 262093 SGTC_649 1123-0311 367 µM 2.67152867796221 0.0817987709183042 no 535 0.00377533101230702 157 693629 YIL048W NEO1 SGTC_3036 9090181 49.47 µM 2.67072260568204 0.0818651743113433 no 536 0.00378440833191617 45 25236586 SGTC_2596 sinensetin 100 µM 2.66968141374009 0.0819510067353973 no 537 0.00379616233406776 99 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_229 benomyl 22.8748 µM 2.66619086820932 0.0822392505340924 no 538 0.00383580620123814 86 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1302 1159-0335 255 µM 2.66092271827991 0.0826757310679022 no 539 0.00389634204460113 70 649284 SGTC_3102 9121669 49.47 µM 2.66006442526798 0.0827470078312868 no 540 0.00390628529707282 50 41905072 SGTC_57 miconazole 162.5 nM 2.64940701676457 0.0836359055996079 no 541 0.00403165785602426 94 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2345 9052315 157.45 µM 2.6489071029725 0.0836777771663165 no 542 0.00403762626645969 102 6469265 SGTC_1530 rhein 70.4 µM 2.64716010483425 0.0838242251775937 no 543 0.00405854563579152 95 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1233 0325-0408 14.2 µM 2.64628856152085 0.0838973571714248 no 544 0.0040690181315884 84 12874 SGTC_2008 4012253 172 µM 2.63636753389508 0.0847332197098849 no 545 0.00418994558845155 109 603940 SGTC_2921 7974240 10.71 µM 2.63591665296483 0.084771354976261 no 546 0.00419551696545197 136 2979074 YDR527W RBA50 SGTC_2152 5568786 200 µM 2.62791058650893 0.085450648582097 no 547 0.0042955547025041 80 5399883 SGTC_3221 9128209 49.47 µM 2.62405046219681 0.0857796230318302 no 548 0.00434454552268111 89 16460723 SGTC_1176 0848-0131 83.3 µM 2.61831041445516 0.086270563396136 no 549 0.0044183189709746 105 6769040 SGTC_3081 9117243 49.47 µM 2.61532869931511 0.0865264142924731 no 550 0.00445708116150611 89 45595589 SGTC_3259 9138485 49.47 µM 2.61303702805209 0.0867234400542577 no 551 0.00448707894095505 89 17646153 SGTC_456 gingerol 170 µM 2.60949927772299 0.0870282551036611 no 552 0.00453374187387552 97 442793 A herb. SGTC_2067 5224629 34.075 µM 2.60137408107118 0.0877313560995566 no 553 0.00464255722877801 106 2835000 SGTC_1531 st059297 52.4 µM 2.60085201873886 0.0877766763995788 no 554 0.00464962788981503 95 7566702 SGTC_1608 st001473 40.5 µM 2.59611978326008 0.0881882792670127 no 555 0.00471415950954697 120 7292267 SGTC_3248 9135562 49.47 µM 2.5936460112978 0.0884040161018198 no 556 0.0047482103146969 76 17650701 SGTC_259 usnic acid 108.925 µM 2.59141365540252 0.088599036462021 no 557 0.00477912619409965 96 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1837 st055472 66.5 µM 2.58609203888723 0.0890652292872047 no 558 0.00485355030311525 98 676091 SGTC_1957 st077035 62.4 µM 2.58483548089365 0.089175574275121 no 559 0.00487127363442569 74 705593 SGTC_1653 st012112 65 µM 2.57897576448637 0.0896914904783431 no 560 0.00495468693181942 73 720429 SGTC_2361 9034121 116 µM 2.55850953472102 0.0915108431217071 no 561 0.00525609686705278 95 6496917 SGTC_2243 6634756 200 µM 2.55656419060555 0.0916851884119379 no 562 0.00528557825367042 91 885676 SGTC_2049 5262831 67.185 µM 2.55583635184061 0.09175048187384 no 563 0.00529664628865269 124 763417 SGTC_2508 celastrol 40.54 µM 2.55362233628833 0.0919493100652859 no 564 0.00533044101356516 85 122724 Celastrol is a natural product and antioxidant. SGTC_2952 9073731 13.78 µM 2.55148658525787 0.0921414119563581 no 565 0.00536322266698626 156 16457353 SGTC_173 1273-0061 2.693 µM 2.54983344521898 0.0922903088770323 no 566 0.00538871966319104 277 2847414 YPL266W DIM1 SGTC_1292 0kpi-0043 232 µM 2.54070722564195 0.0931155060512673 no 567 0.00553142569033716 96 3333905 SGTC_2498 4'-Methoxychalcone 54.63 µM 2.54043712116939 0.093140011842895 no 568 0.00553569997525964 110 641818 YHR062C RPP1 SGTC_3060 1327-0027 12.5 µM 2.53882119336998 0.0932867198222427 no 569 0.00556133266528533 105 16000455 YPR107C YTH1 SGTC_1099 5-nonyloxytryptamine 2.85 µM 2.53740445773192 0.0934154838061462 no 570 0.00558389234483241 106 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1820 st053765 18.6 µM 2.52760435701995 0.0943097902806549 no 571 0.00574218440124194 113 3690829 SGTC_935 2996-0153 430 µM 2.52460239797692 0.0945849928487162 no 572 0.00579146274546772 108 23738523 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 2.52295126974871 0.0947366110331427 no 573 0.00581872631689214 120 115019 SGTC_792 4534-1957 155 µM 2.51580219295554 0.0953951564386517 no 574 0.0059380908130097 127 1717904 SGTC_120 rhodamine 6G 52.259 µM 2.5080321929859 0.0961147136927178 no 575 0.00607028028282668 157 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2464 5717415 7.67 µM 2.50569460044928 0.0963319702502206 no 576 0.00611055635190918 105 5285744 SGTC_1607 st000305 50.6 µM 2.50376332618703 0.096511735554107 no 577 0.00614401010566144 102 5457690 SGTC_2718 lomofungin 53.02 µM 2.50301477033892 0.0965814782588818 no 578 0.00615702024549644 80 5351222 A RNA synthesis inhibitor. SGTC_739 1486-1183 203 µM 2.49949571065144 0.0969098440850467 no 579 0.00621851023495901 98 4346692 SGTC_1604 st002052 72.4 µM 2.49756793071625 0.0970900736548316 no 580 0.00625242518686345 107 6254834 YHR062C RPP1 SGTC_1338 1486-1223 76 µM 2.4967687538334 0.0971648613807854 no 581 0.00626653286281317 110 3444526 SGTC_1747 st037496 66.6 µM 2.49208884346942 0.0976036605959881 no 582 0.00634971336339244 120 723305 SGTC_290 2043-6722 48.1 µM 2.48519282970484 0.098252892369747 no 583 0.00647406383449011 114 773758 YLR208W SEC13 SGTC_1276 0871-0068 94.2 µM 2.48427026560884 0.0983399873782591 no 584 0.00649086205691173 104 3414906 SGTC_961 1252-1571 372 µM 2.48308501139451 0.0984519647103247 no 585 0.00651249997019774 125 6813498 SGTC_713 1488-1073 324 µM 2.47863870656057 0.0988728630480275 no 586 0.00659424104172473 83 3312542 SGTC_2855 9016525 58.44 µM 2.47669418553126 0.0990573495021931 no 587 0.00663027341297393 120 43811474 SGTC_2106 5357045 167.29 µM 2.47514005494219 0.0992049785972001 no 588 0.00665919680705657 110 668842 SGTC_1730 st033808 45.1 µM 2.47222741108666 0.0994820880093447 no 589 0.00671370353594625 177 1045166 SGTC_1250 0485-0349 40.2 µM 2.4714977081475 0.0995516006051765 no 590 0.00672742068549699 137 6842794 YDL195W SEC31 SGTC_3109 9122853 49.47 µM 2.47104546228584 0.0995947000371735 no 591 0.0067359345492114 76 1234709 SGTC_1618 st003135 44.5 µM 2.46443009275955 0.100226709845168 no 592 0.00686156652616944 88 1270615 SGTC_502 l-744,832 89.3 µM 2.46262616198507 0.100399558135663 no 593 0.00689618197441323 139 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_702 1488-0190 94 µM 2.46096710899119 0.100558716515502 no 594 0.00692815341244925 92 949357 SGTC_3010 9080089 71.4286 µM 2.45868072038651 0.100778358760685 no 595 0.00697242860552508 108 17027233 SGTC_1857 st056007 79.3 µM 2.45766348202866 0.100876192280461 no 596 0.00699220726172785 73 619834 SGTC_428 3448-4153 16.5 µM 2.45474923559611 0.101156855039061 no 597 0.00704914480647492 138 3834874 SGTC_804 1595-0054 20.9 µM 2.4518338413368 0.10143819731776 no 598 0.00710651379566505 132 761523 Stimulates phospholipase C. SGTC_1326 1431-2094 10.8 µM 2.44862728617232 0.101748295002699 no 599 0.0071700875797246 129 616278 SGTC_317 4495-0002 170 µM 2.44850841782806 0.101759803705129 no 600 0.00717245389908795 94 15991618 SGTC_3020 9089140 49.47 µM 2.44524403990324 0.102076227637634 no 601 0.00723770784620716 118 17217859 SGTC_1601 4'-hydroxyflavanone 55.5 µM 2.44280898813236 0.102312728763818 no 602 0.00728672416068972 150 165506 SGTC_3184 9108758 49.47 µM 2.44153485963566 0.102436635478056 no 603 0.00731248814710878 65 902885 SGTC_1527 coumarin 137 µM 2.44020030164619 0.102566535810891 no 604 0.00733956014711317 120 323 A hepatotoxic, DNA x-linker. SGTC_648 0375-0473 33.3 µM 2.43903973822065 0.10267959754951 no 605 0.00736317438196096 122 1713139 SGTC_986 1493-0483 84 µM 2.4252608129196 0.104028863777338 no 606 0.00764869619258985 101 40079 SGTC_333 3486-0131 40.1 µM 2.42505070776574 0.10404953683051 no 607 0.00765312433148973 100 6744690 SGTC_905 2-aminofluorene 215 µM 2.42221728877386 0.10432861880979 no 608 0.00771306178662967 143 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2934 9036370 36.88 µM 2.41994968416873 0.104552360530597 no 609 0.0077613273917397 155 6462800 SGTC_3152 9099253 49.47 µM 2.41412274295241 0.105128891345015 no 610 0.00788657388817929 287 25236131 SGTC_1231 0242-0792 125 µM 2.41410909662705 0.105130244238496 no 611 0.00788686928192278 122 3707635 SGTC_1816 st051957 91.6 µM 2.41321311664299 0.10521909905656 no 612 0.00790628532588952 104 674121 SGTC_2194 5927483 104.545 µM 2.39784440479355 0.106751690747102 no 613 0.00824593451469359 124 760979 SGTC_1666 st014829 29 µM 2.3969932931381 0.106837033240354 no 614 0.00826511313947765 129 3858230 SGTC_661 1304-0007 33.6 µM 2.39145616214706 0.10739345339568 no 615 0.00839084395828245 122 3117130 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 2.39113986381453 0.107425300816586 no 616 0.00839807652694548 154 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_100 0086-0128 49.5915 µM 2.38391778000899 0.108154330472441 no 617 0.00856471448612532 188 93297 SGTC_854 0422-0053 192 µM 2.37997348203828 0.108553986119483 no 618 0.00865694197822485 109 3596728 SGTC_1723 st034307 2.5525 µM 2.37445449655385 0.109114978405704 no 619 0.00878745115280391 145 867466 SGTC_2073 5212005 126 µM 2.37225242928708 0.109339394011942 no 620 0.00884000356177111 73 691789 SGTC_2816 7982706 58.44 µM 2.37081072217934 0.109486499783848 no 621 0.00887455896897985 169 2981853 SGTC_850 0388-0143 75.9 µM 2.36972103710679 0.109597780974853 no 622 0.00890075546165356 132 67273 SGTC_442 cape 100 µM 2.36761778993704 0.109812799103925 no 623 0.00895151008032625 102 5281787 SGTC_1068 loratadine 26.9 µM 2.3659207452565 0.109986511121234 no 624 0.00899264705030233 134 3957 A H1 histamine antagonist. SGTC_2162 5663267 200 µM 2.364716390818 0.110109910191738 no 625 0.00902194140271473 102 6456493 SGTC_901 1112-0062 60.1 µM 2.35162856392641 0.1114573065682 no 626 0.00934571455856549 102 1908457 SGTC_3134 9127454 49.47 µM 2.34832437300707 0.111799331960942 no 627 0.00942904515118965 101 24262820 SGTC_1658 st012944 20 µM 2.34327441331185 0.112323515724882 no 628 0.00955765898726097 185 24207260 SGTC_275 trichlorophene 5.69 µM 2.34300345746878 0.11235169039028 no 629 0.00956460291320211 370 62616 SGTC_2016 5121758 140 µM 2.3391739805117 0.112750429088527 no 630 0.00966321556006283 200 2795203 SGTC_2576 guaiol 23.12 µM 2.32611682061783 0.11411758015904 no 631 0.0100061597239421 157 227829 SGTC_1119 parthenolide 318.541 nM 2.32360781848979 0.114381632260636 no 632 0.0100732615068339 209 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_192 3455-0609 60.9 µM 2.32259386290198 0.114488466176113 no 633 0.0101004903625068 119 3769639 SGTC_1345 1488-0192 31.4 µM 2.32170364141221 0.114582321573188 no 634 0.010124449373499 137 658348 SGTC_577 r071-0003 38.6 µM 2.31763063235631 0.115012434318654 no 635 0.0102347019642605 229 4568517 YMR134W ERG29 SGTC_2253 7938677 135.83 µM 2.31631390446731 0.115151727033389 no 636 0.0102705678505894 113 2301972 SGTC_1245 0418-0076 17.2 µM 2.30727598127498 0.116111059570219 no 637 0.0105197198165917 160 6790114 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 2.30256878251702 0.116612946895729 no 638 0.0106515586373558 126 6857784 SGTC_2219 9098279 200 µM 2.28588791327886 0.118403860768991 no 639 0.0111304083646931 102 902349 SGTC_3202 9113761 49.47 µM 2.27846682652949 0.11920683073068 no 640 0.0113493894017589 215 4798415 SGTC_1934 st074720 32.6 µM 2.27479576589303 0.119605461472878 no 641 0.0114590921794007 215 17250992 SGTC_940 3232-1287 54.8 µM 2.27003991604457 0.1201232833796 no 642 0.0116025806453464 168 1585493 YIL048W NEO1 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 2.26761034037381 0.120388426945906 no 643 0.0116764834408696 181 688667 SGTC_725 1497-0963 19 µM 2.26331840123317 0.120857820034223 no 644 0.0118080343810915 134 3549977 SGTC_323 4013-0906 34.3 µM 2.25553563274038 0.121712274149726 no 645 0.0120498641406594 113 2910086 SGTC_2444 5485484 36.41 µM 2.25521336132213 0.121747746959847 no 646 0.0120599698296115 188 6790631 SGTC_124 0136-0217 7.121 µM 2.2509646443958 0.122216087708284 no 647 0.0121938883853414 200 3976905 SGTC_1201 1889-3372 45.9 µM 2.24008654903067 0.123420952431494 no 648 0.0125426523037353 117 5392199 SGTC_1437 4092-1038 11.6 µM 2.23908291686868 0.123532533175696 no 649 0.0125752607912565 147 3977136 SGTC_2991 9074669 71.4286 µM 2.21697934898312 0.126007867399427 no 650 0.013312251373415 223 17333109 SGTC_2216 7189485 200 µM 2.21655733085171 0.126055462434863 no 651 0.0133266780471806 99 731273 SGTC_2052 5265182 7.135 µM 2.21471529694963 0.126263353018883 no 652 0.0133898061161279 173 1239884 SGTC_485 niflumic acid 177 µM 2.21100839175128 0.126682435556361 no 653 0.013517627973583 132 4488 A COX2 inhibitor. SGTC_2013 4024628 200 µM 2.20779333282156 0.127046696232234 no 654 0.0136293415251132 204 5230760 SGTC_359 0081-0058 15.9 µM 2.20327324568779 0.127560046146662 no 655 0.0137877477475311 205 3494159 SGTC_296 1222-0039 74.9 µM 2.20278716865557 0.127615336066663 no 656 0.0138048764844011 152 5984176 SGTC_3023 9089636 49.47 µM 2.20218295360004 0.127684087084479 no 657 0.0138261938385528 122 17249241 SGTC_2224 6650123 117.647 µM 2.1836535134563 0.129804981863488 no 658 0.014493859051956 93 2908370 SGTC_1227 3909-8010 46.6 µM 2.18183616110419 0.130014303484227 no 659 0.0145608133616438 173 15982272 SGTC_603 3794-0023 45.9 µM 2.17905580779365 0.130334994963287 no 660 0.0146637613217891 135 3802260 SGTC_2436 5633522 8.09 µM 2.17794999916223 0.130462693099209 no 661 0.0147048797479815 180 5724242 SGTC_3199 9111318 49.47 µM 2.17384529020438 0.130937459097794 no 662 0.0148583779614636 184 8548020 SGTC_689 0833-0039 98 µM 2.17021451221771 0.131358402390885 no 663 0.0149952996010885 172 5374726 SGTC_2476 5806916 10.51 µM 2.17003407017256 0.131379346734093 no 664 0.0150021325162445 143 2870194 SGTC_2250 alverine citrate 130 µM 2.16925172949683 0.131470181572044 no 665 0.0150317888789837 397 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1303 1160-0052 261 µM 2.16032930745529 0.132509199916546 no 666 0.0153735928600843 161 3562476 SGTC_718 1130-0073 349 µM 2.15043983426389 0.133667426571762 no 667 0.0157602201505848 170 6740020 SGTC_635 k038-0028 24.7 µM 2.14804604866275 0.133948823045429 no 668 0.0158550487500192 210 4035102 SGTC_568 1193-0097 7.48 µM 2.14789873244503 0.133966153783599 no 669 0.0158609005552033 336 3646150 SGTC_1848 st056003 16.4 µM 2.14412852427621 0.134410217184441 no 670 0.0160112950567079 164 146492 SGTC_2267 7931562 200 µM 2.14186129968579 0.134677741967621 no 671 0.0161023224380269 160 934880 SGTC_937 3122-0005 46.7 µM 2.14093958577026 0.134786605477083 no 672 0.0161394551592368 204 759535 SGTC_2979 9012552 45.46 µM 2.12423574167682 0.136769959464609 no 673 0.0168252179614925 131 17100905 SGTC_2950 9072895 21.46 µM 2.12023545241804 0.137247885500374 no 674 0.0169930970133227 254 17332245 SGTC_1737 st035557 69.7 µM 2.11924130622024 0.137366835749299 no 675 0.0170350395492141 157 5716916 SGTC_812 4251-0442 148 µM 2.11676585934614 0.137663330417935 no 676 0.0171398621057032 145 5723007 SGTC_2189 6047310 154.431 µM 2.11207610118051 0.138226239242978 no 677 0.0173399612375201 168 711535 SGTC_1945 st075991 56.6 µM 2.10878538127606 0.138622157979094 no 678 0.017481555506086 187 1084980 SGTC_3281 9140613 49.47 µM 2.10323574607062 0.139291603822898 no 679 0.0177225835047687 161 16013766 SGTC_553 k007-0256 45.7 µM 2.10232606639542 0.139401546880993 no 680 0.0177623613596428 197 6287000 SGTC_909 3448-9333 149 µM 2.1004588414343 0.139627402896851 no 681 0.0178442487872485 165 3344074 SGTC_1294 1000-1494 117 µM 2.09953770582462 0.139738913329245 no 682 0.0178847637955144 196 712797 YDL207W GLE1 SGTC_2135 5326629 150.42 µM 2.09766781296298 0.139965464158839 no 683 0.0179672500450236 187 5020077 SGTC_1409 3909-8004 61.9 µM 2.09747423527011 0.139988931723238 no 684 0.017975807803682 227 2119279 SGTC_2611 pyromycin 23.93 µM 2.09347644055059 0.14047418512069 no 685 0.0181533225080568 213 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1917 st066507 28.5 µM 2.0880067547128 0.141139945129833 no 686 0.0183986126874185 245 3156428 SGTC_798 1287-0182 476 µM 2.08500313116362 0.141506449200708 no 687 0.0185345081560853 230 1649755 SGTC_2604 4'-hydroxychalcone 11.32 µM 2.08454615797828 0.141562265830914 no 688 0.018555258100137 206 5282362 SGTC_2710 st078562 53.7235 µM 2.08164820867853 0.141916580795881 no 689 0.0186873072664768 172 17250908 SGTC_3088 9117578 49.47 µM 2.07793232469998 0.142371777630278 no 690 0.0188577963861844 157 678341 SGTC_2077 5212015 200 µM 2.0760760149417 0.142599545660422 no 691 0.0189434605497671 234 780900 SGTC_2424 5537928 59.2 µM 2.07089191598971 0.143236935666155 no 692 0.0191844489039978 247 5382802 SGTC_811 0416-0114 265 µM 2.06769122163508 0.143631423472228 no 693 0.0193345339520449 213 6612453 SGTC_1432 4049-0298 68.4 µM 2.06050389970793 0.144519935723488 no 694 0.0196751967153844 164 741646 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 2.05333799450645 0.145409479726072 no 695 0.0200199041898101 271 368090 SGTC_101 0490-5701 117.494 µM 2.05278305876647 0.145478520329091 no 696 0.0200468111519369 166 4661669 SGTC_2205 7238770 200 µM 2.05158759767966 0.145627324791397 no 697 0.0201048792591537 135 279867 SGTC_1638 st008370 60.6 µM 2.05084988655743 0.145719202083372 no 698 0.0201407838329144 238 24207134 SGTC_762 1165-0429 115 µM 2.04943117310346 0.145896003449866 no 699 0.0202099858050285 206 5967793 SGTC_3160 9100216 49.47 µM 2.03921890295376 0.147172918453836 no 700 0.0207140925713439 144 17191039 SGTC_1438 4092-1045 4 µM 2.0357114969283 0.14761319844574 no 701 0.0208896669706494 178 1351342 SGTC_1266 0828-0227 32.9 µM 2.02740727845619 0.148659129904342 no 702 0.021310389101397 204 3913820 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 2.02265261781045 0.149260213098933 no 703 0.0215544876048914 231 5377381 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 2.01009439023221 0.15085561566762 no 704 0.0222105998450581 201 4213774 SGTC_2751 anetholtrithion 17.25 µM 2.00642426855013 0.151324005187282 no 705 0.022405500603595 221 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2188 6126565 140.678 µM 2.00636709608955 0.151331309313294 no 706 0.0224085481047889 159 874518 SGTC_1795 st049545 62.3 µM 2.00635469760544 0.151332893325215 no 707 0.0224092090354521 171 5291882 SGTC_2055 5235184 200 µM 1.99855788949813 0.152331185931447 no 708 0.0228281052530553 235 2836034 SGTC_2391 6285546 200 µM 1.99369186700496 0.152956435241906 no 709 0.0230928693666887 266 846083 SGTC_2818 7996756 12.99 µM 1.99002726508203 0.153428432185332 no 710 0.02329396606016 148 2241621 SGTC_54 0159-0055 9 µM 1.98681797376005 0.153842577181918 no 711 0.0234712860402321 218 3319099 SGTC_225 nsc-122657 1.016 µM 1.9862478120203 0.153916231387037 no 712 0.0235029071558738 126 275685 SGTC_269 exalamide 29 µM 1.97577535942836 0.15527322613828 no 713 0.0240901126917193 180 3316 A derivative of salicylamide. SGTC_1056 3448-1962 115 µM 1.97144546342983 0.155836583847607 no 714 0.0243364725984475 203 715507 SGTC_1209 2323-2347 50.3 µM 1.96738759196169 0.156365770504678 no 715 0.0245692718633456 194 5412760 SGTC_734 2023-0417 80 µM 1.95014280566967 0.158627849033406 no 716 0.0255795502446073 235 3935732 SGTC_3164 9100705 49.47 µM 1.94917613938756 0.158755283118447 no 717 0.0256371967066905 166 17174235 SGTC_262 fenpropimorph 62.5 µM 1.94725146447778 0.159009209743415 no 718 0.0257522972163495 225 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_383 2324-0395 7.37 µM 1.94620922292432 0.159146825992126 no 719 0.0258148062503379 253 3146421 SGTC_773 4358-1457 44.6 µM 1.94532590039138 0.159263519837477 no 720 0.0258678833867111 290 1186886 SGTC_89 0302-0250 142.109 µM 1.93092409205597 0.161174014427485 no 721 0.0267462201637998 261 4203518 YLR208W SEC13 SGTC_1714 st033236 13.627 µM 1.92720771324638 0.161669433629922 no 722 0.0269768745529583 244 2916566 SGTC_2406 ethylparaben 405.7 µM 1.92518717287905 0.161939201826818 no 723 0.0271029731221383 239 8434 A possible steroid mimic. SGTC_2852 9023854 51.95 µM 1.92366616281198 0.162142469635559 no 724 0.0271982209908844 236 19798528 SGTC_2984 9022109 38.96 µM 1.92263357255978 0.16228055965554 no 725 0.0272630423141671 164 6459207 SGTC_1545 lovastatin 49.4 µM 1.92074205178528 0.162533714408267 no 726 0.0273821176386381 275 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_450 aminopyrene 156 nM 1.91139529114165 0.163788423147517 no 727 0.0279769006907086 285 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_3098 9119039 49.47 µM 1.909870884112 0.163993654188468 no 728 0.0280749198640698 247 17161528 SGTC_2352 9027995 87.8 µM 1.90910751380282 0.16409648946146 no 729 0.0281241118280911 201 2997347 SGTC_2401 5128683 200 µM 1.90818056684502 0.164221416721524 no 730 0.0281839412095962 239 708373 SGTC_948 3448-0295 75.3 µM 1.90494332862581 0.16465819214859 no 731 0.0283937190841933 278 678569 SGTC_1788 fluconazole 20 µM 1.9044364719608 0.164726646473028 no 732 0.0284266814980527 277 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_230 MPP+ 141.667 µM 1.89874348221449 0.165496788430523 no 733 0.0287991057277484 238 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_223 busulfan 5 mM 1.89253386843935 0.166339470061436 no 734 0.0292099427592297 163 2478 A DNA alkylator. SGTC_367 0335-0881 7.1 µM 1.88992175400316 0.166694776045986 no 735 0.0293842128224663 305 23828853 SGTC_3256 9138902 49.47 µM 1.88626755660537 0.167192649772749 no 736 0.0296294544447668 151 17228773 SGTC_711 k292-0785 179 µM 1.87748272171859 0.168393475808467 no 737 0.0302259816357867 256 4146315 SGTC_1205 4161-2785 76 µM 1.87683485741779 0.168482253435868 no 738 0.0302703656876379 245 3498106 SGTC_1367 1812-0510 76.9 µM 1.87654548348808 0.168521916415808 no 739 0.0302902076340774 264 1142582 YDR527W RBA50 SGTC_3223 9129970 49.47 µM 1.86808572584787 0.169684103937391 no 740 0.0308750614221154 269 17248386 SGTC_458 nppb 133 µM 1.86556654032695 0.170031176495982 no 741 0.0310510172772721 217 4549 A chloride channel blocker. SGTC_2602 kawain 100 µM 1.86259614942721 0.170440996535584 no 742 0.0312595532558893 297 5369129 SGTC_1864 st057645 30.4 µM 1.8547485974369 0.171526751058895 no 743 0.0318160677320977 205 688666 SGTC_3294 9122953 26.2835 µM 1.85336069503789 0.17171923440106 no 744 0.0319153385021468 268 16459826 SGTC_1153 4055-0057 267 µM 1.84968860231735 0.172229169273921 no 745 0.0321792220952833 283 882706 SGTC_1748 st037455 53.6035 µM 1.84192121669572 0.173310987773884 no 746 0.0327433373322613 303 580690 SGTC_3257 9139206 32.98 µM 1.83980167857094 0.173606940525201 no 747 0.0328986794595818 174 4910041 SGTC_3167 9103034 49.47 µM 1.83958768464513 0.173636838525053 no 748 0.0329143968982815 174 5127859 SGTC_1101 ebselen 5.29 µM 1.83618303884973 0.17411295667768 no 749 0.0331652951542154 277 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2443 5493264 126.67 µM 1.82886427494733 0.175139245678041 no 750 0.0337099716213704 254 5340055 SGTC_956 1185-0240 191 µM 1.81603300065284 0.176947777438372 no 751 0.0346826550238977 272 1416193 SGTC_1050 3232-1156 69.3 µM 1.80015470223516 0.179202053365241 no 752 0.0359181070474084 289 700529 SGTC_2332 7982454 138.89 µM 1.79146800609232 0.180442932145913 no 753 0.0366091121496617 355 2981748 SGTC_1470 k295-0292 231 µM 1.78812903472545 0.180921328871161 no 754 0.0368775961123932 293 5045612 SGTC_1424 4048-1941 275 µM 1.78155354700763 0.181865764381876 no 755 0.0374110327090018 314 X1424 SGTC_3292 9120825 59.784 µM 1.78128196698889 0.181904837540008 no 756 0.0374331994649177 279 24824900 SGTC_1043 0916-0009 19.3 µM 1.78102524975161 0.181941777164896 no 757 0.0374541629605021 359 3101130 SGTC_2960 9079389 5.97 µM 1.77490416580235 0.182823942814721 no 758 0.0379568561714084 303 16457355 SGTC_845 0330-0138 4.51 µM 1.77263113790962 0.183152208408314 no 759 0.0381449242810518 275 9039800 SGTC_2925 9010536 32.5 µM 1.76968142105754 0.183578747640604 no 760 0.0383901133004252 386 2994177 SGTC_2603 homopterocarpin 100 µM 1.76786559426591 0.183841630043582 no 761 0.0385416879248407 336 101795 A weak amylase inhibitor. SGTC_1061 3448-9325 110 µM 1.76756663883291 0.183884933139041 no 762 0.0385666896755084 243 723482 SGTC_3012 9080433 71.4286 µM 1.76651344706245 0.184037536459535 no 763 0.0386548737973164 285 17688859 SGTC_2090 5301565 104.445 µM 1.76467929203554 0.184303486425007 no 764 0.0388088403936771 340 2056344 SGTC_3037 9091026 49.47 µM 1.76071951354592 0.184878463808408 no 765 0.0391429441581641 457 25236398 YIL048W NEO1 SGTC_784 4579-0127 173 µM 1.7604026646404 0.184924519793472 no 766 0.0391697789385807 293 1948547 SGTC_697 0508-1955 564 µM 1.75004386305384 0.186434161715395 no 767 0.0400553726223791 331 6243113 SGTC_756 0508-1999 28.3 µM 1.74879239939833 0.186617059435477 no 768 0.0401634555490501 304 6753853 SGTC_3265 9137266 49.47 µM 1.74778409279404 0.186764501255874 no 769 0.0402507104064285 241 17224265 SGTC_3079 9117512 49.47 µM 1.74595621228993 0.187031970822149 no 770 0.0404092804589811 217 7185044 SGTC_886 0866-0150 153 µM 1.74390920945934 0.187331785174793 no 771 0.0405874612490734 334 271463 SGTC_3262 9137218 49.47 µM 1.7438503666703 0.187340407977227 no 772 0.0405925926176595 148 17650664 SGTC_2553 4-methylesculetin 85.09 µM 1.72618140294843 0.189940701789211 no 773 0.0421573913247467 322 5319502 SGTC_2594 a-mangostin 100 µM 1.72333198783391 0.190362110542078 no 774 0.0424142531601601 353 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_356 1634-0012 32.5 µM 1.72299736472546 0.19041163663124 no 775 0.0424445007974191 342 735457 SGTC_206 4546-0025 72.014 µM 1.72149200179163 0.190634536610056 no 776 0.0425807911530893 391 6620745 YIL048W NEO1 SGTC_3038 9091290 49.47 µM 1.71765509653798 0.191203393405431 no 777 0.0429297721493779 313 25236843 SGTC_91 0417-1751 58.384 µM 1.7152154436158 0.191565635207702 no 778 0.0431528672173541 413 6795624 SGTC_1726 st035556 14.5795 µM 1.71048436438986 0.192269307103893 no 779 0.0435881711553586 353 5919439 SGTC_1030 k029-0042 36.7 µM 1.71033429657758 0.192291653113946 no 780 0.0436020365855196 363 6080581 SGTC_2531 methyl deoxycholate 70.07 µM 1.70856477828758 0.192555264925703 no 781 0.0437657988047608 303 16667744 Haematoxylin. SGTC_1966 st070145 16.1 µM 1.70748595194963 0.192716090091164 no 782 0.0438658833459692 307 3748532 SGTC_1789 tunicamycin 25 nM 1.69018956336932 0.195305728780663 no 783 0.0454958472013363 322 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1328 1441-0025 69.2 µM 1.68587135243675 0.195955540380343 no 784 0.0459102904084612 288 4562601 SGTC_1191 1487-1166 10.6 µM 1.68562790414794 0.195992213902899 no 785 0.0459337455592449 406 3955771 SGTC_2154 5570129 200 µM 1.68226418604973 0.196499357028073 no 786 0.0462588112894961 356 673366 SGTC_2150 5556613 200 µM 1.6786918297832 0.197038826043494 no 787 0.0466060595404723 354 743190 SGTC_276 colchicine 750 µM 1.67719866971803 0.197264576659366 no 788 0.0467518195511967 360 2833 A microtubule depolymerizer. SGTC_470 aa-861 153 µM 1.67359885532618 0.197809474926256 no 789 0.0471047318218626 391 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_3097 9117246 49.47 µM 1.67238887587468 0.197992831636389 no 790 0.0472238321219018 340 16423892 SGTC_2228 7354201 200 µM 1.67210425211827 0.198035977587429 no 791 0.0472518831516539 280 753451 SGTC_2783 7738165 71.43 µM 1.66746510805831 0.198740022966806 no 792 0.0477109784406245 266 17201110 SGTC_2448 5185112 27.17 µM 1.66663370305015 0.198866357861144 no 793 0.047793631489148 313 5718189 SGTC_1319 1306-0155 43.7 µM 1.66269562702237 0.199465419654145 no 794 0.0481866890054011 382 3122360 SGTC_3332 9141069 11.198 µM 1.65971049911438 0.199920241560048 no 795 0.0484863531072607 299 17332883 SGTC_1742 st038235 28.8875 µM 1.65565559016826 0.200539056075829 no 796 0.048895792806406 399 564103 YBR002C RER2 SGTC_2651 TUB2.036 5 µM 1.65548152245995 0.200565646050928 no 797 0.0489134307452537 569 15992207 YFL037W TUB2 SGTC_459 nigericin 15.3 µM 1.65371774476985 0.200835193957947 no 798 0.0490924377469798 390 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_103 0844-0104 51.839 µM 1.65260063350111 0.201006027981239 no 799 0.049206084537812 496 5375804 SGTC_1833 st055984 71 µM 1.64114560400516 0.202762810879009 no 800 0.0503835970632265 326 676288 SGTC_1669 st015249 58.4 µM 1.63844115283811 0.203178909594503 no 801 0.0506648501966463 299 722793 SGTC_2680 butyl paraben 22.24 µM 1.63447705581578 0.203789733904631 no 802 0.0510793600460469 296 7184 An antifungal and steroid mimetic. SGTC_479 n-linoleoylglycine 10 µM 1.6333406976697 0.203965036023669 no 803 0.0511986809179521 289 6433346 An anti-infammatory. SGTC_2853 9015042 58.44 µM 1.63241222179017 0.204108335528703 no 804 0.0512963380960301 320 6457456 SGTC_429 1112-0049 25.5 µM 1.63104348652824 0.204319693305511 no 805 0.0514405719729744 344 2836170 SGTC_2885 9057732 51.95 µM 1.63018422288459 0.204452445893293 no 806 0.0515312836906558 342 6471414 SGTC_2842 9000675 19.48 µM 1.61446450229709 0.206890124683534 no 807 0.0532133552637983 355 2989072 SGTC_836 0330-0104 1.35 µM 1.61408280507364 0.206949528124605 no 808 0.0532547332683081 350 46494820 SGTC_1552 6-methylflavone 10.6 µM 1.61295775651803 0.207124677853714 no 809 0.0533768428897061 297 689013 SGTC_408 cantharidin 100 µM 1.61221637982816 0.207240144723048 no 810 0.0534574310566607 404 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_181 1447-1644 8.07 µM 1.60821205142825 0.207864462868257 no 811 0.0538943723194106 366 534600 SGTC_990 3985-0011 41.3 µM 1.60508321629237 0.208353054198741 no 812 0.0542377461900209 318 5399565 YGL099W LSG1 SGTC_1871 st057448 67.3 µM 1.60403408523877 0.208517035502981 no 813 0.0543532697902023 386 691747 SGTC_2798 7813637 45.45 µM 1.60172782631538 0.208877775830731 no 814 0.0546079045266939 397 956368 SGTC_585 0kpi-0023 191 µM 1.59977566738669 0.209183415696258 no 815 0.0548241793262809 343 64601 SGTC_3214 9129694 49.47 µM 1.59819113764233 0.209431691156139 no 816 0.0550002227376149 355 17158655 SGTC_2870 9038528 12.99 µM 1.59568456029859 0.20982479350767 no 817 0.055279618734556 343 6463316 SGTC_85 0868-0259 160.055 µM 1.59534026482827 0.209878822653055 no 818 0.0553180830815132 338 83173 SGTC_3268 9137683 49.47 µM 1.5923068278985 0.210355203136853 no 819 0.0556578897605377 299 1953228 SGTC_1472 k841-0093 193 µM 1.58222730338839 0.211942675927553 no 820 0.0567988447477616 412 X1472 SGTC_3169 9102970 49.47 µM 1.57863801058612 0.212509658505228 no 821 0.0572095554381143 316 17027839 SGTC_3243 9134147 49.47 µM 1.57709593902543 0.212753523660791 no 822 0.0573867257493054 337 24282180 SGTC_147 4466-0538 29.23 µM 1.57404567431636 0.213236377306989 no 823 0.0577384452601527 420 6742687 YHR072W ERG7 SGTC_2113 5491891 107.031 µM 1.57212949327912 0.213540033260815 no 824 0.0579602614045578 411 789979 SGTC_2872 9044037 25.97 µM 1.57038105799461 0.213817326385122 no 825 0.058163243266923 289 6465195 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.57026915953044 0.21383508006053 no 826 0.0581762529363644 369 521171 SGTC_2807 7945238 51.95 µM 1.56952329996965 0.213953439167133 no 827 0.058263027344481 404 17148797 SGTC_903 1134-0042 114 µM 1.5652517153914 0.214632023483275 no 828 0.0587619499116288 396 701009 SGTC_1746 st038117 42 µM 1.56210645698288 0.215132478174211 no 829 0.059131456012275 402 2898218 SGTC_3110 9122132 49.47 µM 1.56039348669414 0.215405320440072 no 830 0.0593334615393652 383 918317 SGTC_1048 3161-0300 24.5 µM 1.55962766442229 0.215527365679298 no 831 0.0594239475378289 424 2165101 SGTC_527 4476-4215 268 µM 1.55410269820364 0.216409039288792 no 832 0.0600799608577157 398 4418754 SGTC_2461 5755302 26.15 µM 1.55367808683655 0.216476884998888 no 833 0.0601306113080436 435 2788904 SGTC_657 3534-0529 86.7 µM 1.55023345697194 0.21702773329945 no 834 0.0605427461328744 384 1049549 SGTC_1842 st055362 61.2 µM 1.54970146149002 0.217112879558452 no 835 0.0606065936003264 419 676032 SGTC_2821 7996764 71.43 µM 1.5485260990308 0.217301065575177 no 836 0.0607478415211679 436 2987135 SGTC_2664 lyso-paf C-16 73.48 µM 1.54803169289329 0.217380252546374 no 837 0.0608073331155286 409 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_247 mechlorethamine 29.705 µM 1.54713579701904 0.21752378689918 no 838 0.0609152517959084 317 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2356 9061756 188.97 µM 1.54412039480839 0.218007295892825 no 839 0.0612795844703588 349 20104043 SGTC_3187 9109394 49.47 µM 1.54396930690864 0.218031538588626 no 840 0.06129788419481 417 17098090 SGTC_1887 st057648 70.8 µM 1.53975420796954 0.218708495345751 no 841 0.0618101389090886 394 688672 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.53489866700224 0.219489806224921 no 842 0.0624043605114243 357 364106 SGTC_1565 sinapyl alcohol 95.1 µM 1.53370303728593 0.219682442158537 no 843 0.0625513631123263 393 5280507 A phenol propionate derived from cinnamic acid. SGTC_148 3253-0744 288.01 µM 1.53299599278983 0.219796404508578 no 844 0.062638421126648 379 6893655 SGTC_2726 cimetidine 79.27 µM 1.53157023678061 0.220026312896789 no 845 0.0628142609162001 322 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2869 9037858 32.47 µM 1.53052277000256 0.220195308637541 no 846 0.062943690860784 338 27187042 SGTC_595 3909-8003 73.7 µM 1.52807240407487 0.220590935321782 no 847 0.0632472811007981 402 699517 SGTC_1087 pterostilbene 9.05 µM 1.52720031069499 0.22073183837594 no 848 0.0633556045437906 443 5281727 Similar to reservatol, lowers cholesterol. SGTC_3239 9133757 49.47 µM 1.51951588356705 0.221975627915507 no 849 0.0643163465211738 353 17036923 SGTC_1767 st044992 70.3 µM 1.51948408398987 0.221980783246533 no 850 0.0643203456412658 438 9600693 SGTC_126 0417-1624 672.48 µM 1.50797118073323 0.223851736839744 no 851 0.0657809515489506 513 41912 YDL195W SEC31 SGTC_2962 9082311 13.18 µM 1.50602730990257 0.224168515899823 no 852 0.0660300815472863 393 16459453 SGTC_781 4335-2806 94.4 µM 1.50489325207156 0.224353442911088 no 853 0.066175761729499 470 845254 SGTC_489 paxilline 115 µM 1.50206539197631 0.224814949573478 no 854 0.0665401108045273 382 105008 A toxic potassium channel blocker. SGTC_2923 7992654 58.14 µM 1.50041222341498 0.225084995742956 no 855 0.0667538275878956 413 2985126 SGTC_1258 0671-0043 57.1 µM 1.50000485259821 0.225151568247519 no 856 0.0668065727742927 440 4298767 SGTC_1940 st075990 51.1 µM 1.49895153686248 0.225323752714362 no 857 0.0669431025062523 461 1084979 SGTC_2587 piperic acid 92.2 µM 1.49431978735596 0.226081784388189 no 858 0.0675460278382147 396 5370536 SGTC_3329 9141233 27.5565 µM 1.49208979218462 0.226447258589521 no 859 0.0678378037693644 394 4909101 YNL103W MET4 SGTC_95 0471-0001 561.058 µM 1.49115110888228 0.226601199235381 no 860 0.0679609132294056 438 4015405 SGTC_272 doxorubicin 8.13 µM 1.48426553917743 0.227732211826354 no 861 0.0688692443554781 490 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3263 9137018 49.47 µM 1.48140330703863 0.22820329076679 no 862 0.0692495670088789 435 43844957 SGTC_1660 st012960 28.1 µM 1.48078299648143 0.228305456429039 no 863 0.0693322044842948 449 24207266 SGTC_1314 1222-0010 41.1 µM 1.47964186444837 0.22849346894852 no 864 0.0694844239255059 407 3526027 SGTC_1215 3852-0577 11.2 µM 1.47796244737326 0.228770327263229 no 865 0.0697089149510756 478 2884876 SGTC_44 0929-0055 61.211 µM 1.47612166772927 0.229074003030654 no 866 0.0699556165473849 397 1379590 SGTC_2822 7994718 71.43 µM 1.4749139105198 0.229273371070362 no 867 0.0701178449991759 348 1018011 SGTC_107 0358-0022 2.6945 µM 1.47451157066041 0.229339808092104 no 868 0.0701719523360698 295 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1936 st074407 74.3 µM 1.47147171322264 0.229842118137175 no 869 0.0705817959372475 480 809813 SGTC_2215 7188065 200 µM 1.47112445467155 0.229899538772305 no 870 0.0706287313309135 355 940217 SGTC_2765 myclobutanil 7.74 µM 1.47050005298863 0.230002806366607 no 871 0.0707131856703474 442 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_3135 9127742 49.47 µM 1.46788277290779 0.230435951441298 no 872 0.0710680341973629 406 3643468 SGTC_559 1550-0661 158 µM 1.46735429994456 0.230523466032243 no 873 0.0711398497485133 434 5830875 SGTC_357 1325-0123 420 µM 1.45887817225034 0.231929639769984 no 874 0.0722993209345116 419 1098503 SGTC_706 4262-0057 46.9 µM 1.45504909310131 0.232566439822723 no 875 0.0728278354452674 440 883298 SGTC_3092 9117248 49.47 µM 1.45071756066147 0.233287971346779 no 876 0.0734292617597951 432 17141857 SGTC_2552 juarezic acid 87.02 µM 1.44804608809955 0.233733594524733 no 877 0.0738020807714219 522 1549512 SGTC_646 4092-0839 27.3 µM 1.44643746729457 0.234002152889555 no 878 0.0740272696817124 437 877796 SGTC_60 0986-0278 202 µM 1.44557636196995 0.23414598416219 no 879 0.0741480303123561 329 3110598 SGTC_1461 k072-0203 53.8 µM 1.44156282050575 0.234817015349089 no 880 0.0747128716653855 426 5418714 SGTC_2319 6033012 152.6 µM 1.4414680607296 0.234832871240412 no 881 0.0747262471443342 388 847246 SGTC_286 k060-0067 22.9 µM 1.44008266056937 0.235064753979226 no 882 0.0749220070689696 436 5985051 SGTC_1853 st056710 91.2 µM 1.43630697218016 0.235697355216987 no 883 0.0754575054873315 458 269167 SGTC_571 k831-0106 44.2 µM 1.43495215916504 0.235924577311805 no 884 0.0756503654127944 425 4783639 SGTC_2402 5553605 200 µM 1.43371001165155 0.236133009789424 no 885 0.0758275169891778 477 6758546 SGTC_1069 diphenylcyclopropenone 8.49 µM 1.43279621181726 0.236286410231841 no 886 0.0759580421237253 524 65057 A dermal irritant. YDR527W RBA50 SGTC_1064 honokiol 6.76 µM 1.4321317062763 0.236397995857311 no 887 0.0760530660015772 481 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_486 niguldipine 82 µM 1.43178443136761 0.236456322768749 no 888 0.0761027620900371 390 1236 A calcium channel blocker. SGTC_1629 st005085 44.9 µM 1.43119054637244 0.236556087681488 no 889 0.0761878061059396 465 24207091 SGTC_3151 9099821 49.47 µM 1.42661338798885 0.237325767062968 no 890 0.0768456815407243 417 17174189 SGTC_112 phenothiazine 287.218 µM 1.42435386670975 0.237706226884724 no 891 0.0771720307972183 461 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2193 5925765 200 µM 1.42375961346201 0.237806343218236 no 892 0.0772580351796888 380 877370 SGTC_1492 4158-0558 28.5 µM 1.41962557909464 0.238503460947175 no 893 0.0778583572700126 434 3967268 SGTC_1774 st048371 48.465 µM 1.41553413473179 0.23919449683068 no 894 0.0784559737301787 488 4242727 SGTC_534 k292-0788 63.4 µM 1.41195892056174 0.239799237196266 no 895 0.0789810285823736 526 4146317 SGTC_1012 4112-3522 18 µM 1.41086443520442 0.239984533843165 no 896 0.0791422952946824 462 3112398 SGTC_426 0988-0037 14.6 µM 1.40842570238385 0.240397692584686 no 897 0.0795025264591777 539 5383008 SGTC_796 1234-0020 70.7 µM 1.40579384704974 0.240844003572412 no 898 0.0798926748348688 487 46495034 SGTC_2621 lithochol-11-enic acid 100 µM 1.40370195138999 0.241199069310653 no 899 0.0802038105693326 529 6708711 SGTC_1885 st057546 99.9 µM 1.39598845850361 0.242510766317326 no 900 0.0813589853582976 504 702008 SGTC_1605 st000082 49.1 µM 1.39590423502633 0.242525110003458 no 901 0.0813716675917776 457 1114022 SGTC_2075 5212009 200 µM 1.3942172644927 0.242812506406445 no 902 0.0816260030117419 416 780898 SGTC_1781 st038725 66.3 µM 1.392543202352 0.24309788580795 no 903 0.0818789843465998 593 4270275 YIL048W NEO1 SGTC_1650 st011916 45.8 µM 1.390820066631 0.2433918201719 no 904 0.0821399982564621 430 242528 SGTC_1817 st052116 64.4 µM 1.38871128598037 0.243751799425535 no 905 0.0824602804591595 466 4361398 SGTC_3264 9137442 49.47 µM 1.38817831386146 0.243842825871436 no 906 0.0825413770650738 440 17015726 SGTC_1651 st011928 86.1 µM 1.38461863306899 0.244451254839852 no 907 0.0830845554290727 482 720198 SGTC_1756 st041558 35.5 µM 1.38390791167721 0.244572830888503 no 908 0.0831933269540738 529 3955792 SGTC_220 paclitaxel 373.376 µM 1.38382059110463 0.244587770197601 no 909 0.0832066982113374 417 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_271 rotenone 740 µM 1.38351298921977 0.244640400423879 no 910 0.0832538136599156 532 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2558 carylophyllene oxide 100 µM 1.38338911936797 0.244661596094125 no 911 0.083272792496411 518 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2306 7482397 179.52 µM 1.3825348561286 0.244807798067418 no 912 0.083403767822354 504 891448 SGTC_336 4111-0029 111 µM 1.37987129994271 0.245263951300578 no 913 0.0838131373278584 422 3131175 SGTC_1519 esterone 74 µM 1.37760355836849 0.245652678263949 no 914 0.0841628608566406 507 698 A steroid. SGTC_2877 9040724 71.43 µM 1.37749585703794 0.245671148211049 no 915 0.0841794974020618 472 6463895 SGTC_2804 7954240 19.48 µM 1.37669337174293 0.245808791722956 no 916 0.0843035344423771 528 828705 SGTC_2418 pentamidine 31.67 µM 1.37611247844393 0.24590845325807 no 917 0.0843934064088422 475 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.37565287119974 0.245987321594341 no 918 0.0844645647260863 486 6312947 SGTC_1020 4335-0961 93.3 µM 1.37423144315013 0.246231323690735 no 919 0.0846849210494884 466 669075 SGTC_3203 9113543 49.47 µM 1.36806016299896 0.247292187706437 no 920 0.0856466224730374 495 17018012 SGTC_2506 ethyl hematommate 54.16 µM 1.36790609163136 0.247318704326474 no 921 0.0856707363738249 413 3940691 An allergen. SGTC_2001 4023502 57.655 µM 1.36534738049944 0.247759296230054 no 922 0.0860719469159483 527 108941 YCR052W RSC6 SGTC_349 k015-0014 24 µM 1.36311249675932 0.248144469973353 no 923 0.0864235294437334 484 2196908 SGTC_412 gemfibrozil 100 µM 1.36090771173296 0.248524769053184 no 924 0.0867714280817793 429 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.35581592894639 0.24940422612901 no 925 0.0875788709194103 490 689007 SGTC_2545 solidagenone 89.61 µM 1.351484433303 0.25015366584733 no 926 0.0882701515658001 309 6708572 An anti ulcer agent SGTC_3063 1327-0034 4 µM 1.35055086253674 0.250315349521677 no 927 0.0884196751182422 487 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2331 7980721 200 µM 1.34282373654232 0.25165572279469 no 928 0.0896645277365025 529 2981221 SGTC_889 0919-1524 82.7 µM 1.34127468757771 0.251924881467604 no 929 0.0899156424733199 483 3905452 SGTC_2529 gangaleoidin 93.61 µM 1.34053118162499 0.252054125049451 no 930 0.090036356932752 493 4565183 SGTC_2171 5739187 198.077 µM 1.33732632381753 0.252611625362762 no 931 0.0905580710168166 440 2262761 SGTC_1867 st057372 64 µM 1.33478779653888 0.253053674874016 no 932 0.0909729043463009 526 688837 SGTC_314 1671-0008 2.74 µM 1.33412441460199 0.253169260722952 no 933 0.0910815428434404 576 3913060 SGTC_2114 5491910 81.25 µM 1.3306343411101 0.253777818567113 no 934 0.0916546785534075 524 2849228 SGTC_2365 9042475 200 µM 1.32957520116352 0.253962650681015 no 935 0.0918291366603976 549 6464479 SGTC_2772 vinpocetine 57.06 µM 1.32607209465713 0.254574485937308 no 936 0.0924079091503009 512 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2517 totarol 10 µM 1.32563208459531 0.254651390464807 no 937 0.0924807966524156 474 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_497 capsazepine 133 µM 1.32414124281922 0.254912048752569 no 938 0.09272807024619 508 2733484 A calcium channel blocker. SGTC_3061 glucosamine 200 µM 1.32229713979662 0.255234664191545 no 939 0.0930346124159322 502 91431 and experimental redox chemotherapeutic SGTC_3137 9097352 49.47 µM 1.32178135932602 0.255324935269197 no 940 0.0931204836432036 580 44120435 SGTC_683 panaxydol 45 µM 1.32054603336834 0.255541207885075 no 941 0.0933263886448785 561 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_7 0192-1582 4.227 µM 1.31865955374338 0.255871664698975 no 942 0.0936414771440899 649 252616 SGTC_1913 st060213 96.1 µM 1.31838902738163 0.255919071391667 no 943 0.0936867260217076 578 688959 SGTC_629 3448-6466 76.7 µM 1.31820927408062 0.255950573663903 no 944 0.0937168009086686 554 573744 SGTC_3212 9128307 49.47 µM 1.31650172880383 0.256249926652719 no 945 0.0940028492737113 467 27243542 SGTC_777 1315-0167 517 µM 1.31583560987788 0.256366754690655 no 946 0.0941146121800009 513 4221767 SGTC_2912 7964298 10.93 µM 1.31387070989535 0.256711532582609 no 947 0.0944448584971201 612 2975850 SGTC_1419 3993-2473 62.6 µM 1.30978145629901 0.257429840673689 no 948 0.0951348890461208 552 704026 SGTC_3304 9125678 46.087 µM 1.30844729895115 0.257664421151331 no 949 0.0953608193279788 563 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_264 promethazine 12.5 mM 1.30539778602725 0.258201023393903 no 950 0.0958787159416757 672 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1850 st056238 17 µM 1.30113972534657 0.258951253665491 no 951 0.096605316120611 603 5393177 SGTC_1579 chlormadinone acetate 49.4 µM 1.29828954327976 0.259454058199724 no 952 0.0970939291323297 549 45114258 A steroidal progestin. SGTC_405 ebelactone b 50 µM 1.29639648879121 0.259788293014448 no 953 0.097419460574396 567 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2796 7949634 45.45 µM 1.29602330489778 0.2598542080001 no 954 0.097483727989061 529 2971588 SGTC_1124 fisetin 1.16336 µM 1.2960030393875 0.259857787717799 no 955 0.0974872188794727 496 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1053 3366-3204 134 µM 1.29560994519906 0.259927229256141 no 956 0.097554950523544 580 3632071 YPR165W RHO1 SGTC_3300 9124615 50.48 µM 1.2949657616017 0.260041047355945 no 957 0.0976660204467159 540 24824903 SGTC_569 4130-2812 160 µM 1.29439054012022 0.260142702542977 no 958 0.0977652782829324 430 743552 SGTC_2341 7987486 176.74 µM 1.29100247376651 0.260741869060663 no 959 0.0983514098600653 590 1258686 SGTC_411 enrofloxacin 100 µM 1.2905006599305 0.260830673247482 no 960 0.0984384414257169 536 71188 A bacterial gyrase inhibitor. SGTC_1903 st060211 78.3 µM 1.29019385702393 0.260884974715817 no 961 0.0984916792426764 584 688960 SGTC_787 4152-0075 138 µM 1.28333606424335 0.262100260633791 no 962 0.0996871814540973 539 9566539 SGTC_3322 9139058 2.11 µM 1.28194488666451 0.262347148065206 no 963 0.0999309901953679 556 4908926 YPR165W RHO1 SGTC_2208 7283366 200 µM 1.28037848809914 0.262625273829418 no 964 0.100206027915852 562 898663 SGTC_843 0310-0051 143 µM 1.2799727623622 0.262697338057769 no 965 0.100277357706551 563 2065037 SGTC_3027 9089541 49.47 µM 1.27957670360711 0.262767695011857 no 966 0.100347023704126 578 9943819 SGTC_842 0271-0008 11.1 µM 1.27723321323423 0.263184196159113 no 967 0.100759962216916 601 1221709 SGTC_119 0121-0043 24.815 µM 1.27610240535086 0.263385291637879 no 968 0.100959660721086 733 1092378 SGTC_2906 7926292 26.41 µM 1.27270098439532 0.263990650612107 no 969 0.101562084096236 560 2966319 SGTC_908 3448-7491 47.7 µM 1.27176178523223 0.264157926957218 no 970 0.101728885298758 657 1203031 SGTC_3115 9123671 49.47 µM 1.2715386503205 0.264197676402543 no 971 0.101768543227793 562 3286988 SGTC_2133 5320837 200 µM 1.27102374788944 0.264289413189354 no 972 0.101860100157231 520 2841355 SGTC_1203 3992-3522 103 µM 1.27013736857398 0.264447371557489 no 973 0.102017851338512 607 5322312 SGTC_1102 cgs 12066b 26.1 µM 1.26991713819963 0.264486625445757 no 974 0.102057073856114 528 6438352 A 5-HT1B full agonist. SGTC_1456 k015-0012 13 µM 1.26723513521437 0.264964903785883 no 975 0.102535613050752 647 2989616 SGTC_2064 5220758 200 µM 1.26721809184225 0.264967944514449 no 976 0.102538659239499 621 788518 SGTC_3132 9126706 49.47 µM 1.26620238135516 0.265149190657671 no 977 0.102720317587642 529 850858 SGTC_390 dec-rvkr-cmk 16.7 µM 1.2650437242882 0.265356021428851 no 978 0.102927827177978 598 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_158 k038-0087 26.446 µM 1.26478292297271 0.265402588111484 no 979 0.102974577328922 689 X158 SGTC_2905 7799065 20.05 µM 1.26332806669844 0.265662432158705 no 980 0.103235651818336 536 1296806 SGTC_1925 st057770 10.1 µM 1.26306331198805 0.265709732442399 no 981 0.103283213792026 525 5989122 SGTC_3017 9080681 49.47 µM 1.26247082141649 0.265815600500926 no 982 0.103389709651161 554 16451914 SGTC_2340 7987427 183.45 µM 1.26062682111245 0.266145228968262 no 983 0.103721665311027 567 2239331 SGTC_1108 betulinic acid 729.144 nM 1.25980540928799 0.266292128910185 no 984 0.103869783977317 580 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2420 aureobasidin a 50 nM 1.25946760784494 0.266352552671565 no 985 0.1039307415248 624 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_417 st075190 100 µM 1.25938354145231 0.266367591008205 no 986 0.103945915654023 602 222757 SGTC_3213 9129884 49.47 µM 1.25813021406204 0.266591845205037 no 987 0.104172333976404 492 17190742 SGTC_2894 9048625 32.47 µM 1.251999943404 0.26769009024197 no 988 0.105284942292963 565 4092861 SGTC_3073 9114972 49.47 µM 1.24767969168555 0.268465435625159 no 989 0.106074190666664 519 41905075 SGTC_427 1354-0053 47.3 µM 1.24746370154548 0.268504228481325 no 990 0.10611376088043 580 6813657 SGTC_3064 1327-0027 10 µM 1.24629965453251 0.268713345366007 no 991 0.106327202330225 408 16000455 YPR107C YTH1 SGTC_2889 9059656 51.95 µM 1.24286799577932 0.269330306379137 no 992 0.106958240475004 623 3949838 SGTC_3130 9127414 49.47 µM 1.24248883412973 0.269398517534715 no 993 0.107028128846675 565 1494646 SGTC_966 1300-0360 30.2 µM 1.23690356833728 0.270404308834845 no 994 0.108061442575679 601 70588 SGTC_1190 1486-1332 13 µM 1.23628111018624 0.270516516848001 no 995 0.108177045073957 576 4150046 SGTC_2947 9072639 7.68 µM 1.234433522783 0.270849710899284 no 996 0.108520701931557 638 16488146 SGTC_1283 0922-0125 16.4 µM 1.23358074147905 0.271003570603129 no 997 0.108679586477387 636 3360884 SGTC_1356 1502-0781 85.8 µM 1.23297928594059 0.271112112060782 no 998 0.108791746238504 588 567702 SGTC_389 tpck 16.7 µM 1.23071491780471 0.271520944794362 no 999 0.109214753339631 583 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2959 9079155 11 µM 1.22681238064915 0.272226269584681 no 1000 0.10994655821214 524 16189457 SGTC_2563 tomatine 8.54 µM 1.22378519062968 0.272774014953044 no 1001 0.110516636206161 673 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_992 3909-8734 162 µM 1.22370364762006 0.27278877705544 no 1002 0.110532021573297 583 4288319 SGTC_1904 st060225 78 µM 1.22275771478818 0.272960052544294 no 1003 0.110710610452477 589 66595 SGTC_430 0958-0115 16.4 µM 1.22198181850917 0.273100580129642 no 1004 0.110857251303378 588 6833180 SGTC_1321 1326-2144 215 µM 1.22147868179078 0.273191725630072 no 1005 0.110952416187457 570 3513030 SGTC_688 0527-0193 473 µM 1.22138012734458 0.273209580980482 no 1006 0.110971063941655 562 4007154 SGTC_910 3454-3003 490 µM 1.22103877124888 0.2732714297695 no 1007 0.111035670208173 636 820824 SGTC_2956 9076196 2.52 µM 1.21927218117305 0.273591621127449 no 1008 0.111370451779715 612 16423868 SGTC_950 1165-0508 94.1 µM 1.21712702112272 0.273980677053368 no 1009 0.111777945641555 574 6148369 SGTC_1686 st019653 115.5 µM 1.21565240997961 0.274248277691875 no 1010 0.112058680074064 597 97252 SGTC_2397 5161689 200 µM 1.21540726862751 0.274292776492904 no 1011 0.112105398566242 642 2259942 SGTC_3123 9126162 49.47 µM 1.21438939153394 0.274477582751764 no 1012 0.112299532241153 594 25239884 SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.21150638952702 0.275001355235328 no 1013 0.112850693664833 433 6708630 An antioxidant. SGTC_2520 obtusaquinone 4.71 µM 1.20992797041199 0.275288324662786 no 1014 0.113153266654113 604 5967872 SGTC_3053 9095903 49.47 µM 1.209610035419 0.275346145658799 no 1015 0.11321428276156 599 17174018 SGTC_2117 5521686 200 µM 1.20777617577625 0.275679775700964 no 1016 0.113566683905024 609 803312 SGTC_1174 0739-0097 51.1 µM 1.20495991754558 0.276192517966028 no 1017 0.11410938793106 631 728447 SGTC_973 1325-0077 65.9 µM 1.20290750617906 0.276566485000507 no 1018 0.114506057657695 674 2835149 SGTC_1459 k035-0031 35.7 µM 1.19784984766905 0.277489092078199 no 1019 0.115487738613043 540 3877128 YMR208W ERG12 SGTC_71 0417-1750 47.813 µM 1.19533834516018 0.277947793199353 no 1020 0.115977431937468 658 6811472 SGTC_1202 1988-0068 29.6 µM 1.19499393360178 0.27801072540904 no 1021 0.116044700146731 639 2850480 SGTC_794 k038-0031 316 µM 1.19479152902136 0.27804771279871 no 1022 0.116084245401859 724 6624242 SGTC_2184 6075246 200 µM 1.19413539335521 0.278167631457936 no 1023 0.116212505160267 627 2267320 SGTC_2318 6029776 164 µM 1.19398076029586 0.278195896646939 no 1024 0.116242747081226 640 818325 SGTC_694 1315-0438 43.2 µM 1.19175573191721 0.278602761873424 no 1025 0.11667851908381 538 6793154 SGTC_1267 0828-0272 9.49 µM 1.190838095293 0.278770643839182 no 1026 0.116858575241858 669 745334 SGTC_815 1582-0027 36.9 µM 1.18959826044131 0.278997550271728 no 1027 0.117102164954308 624 3128206 SGTC_362 0310-0100 9.03 µM 1.18936753415178 0.279039786193914 no 1028 0.117147535303965 611 790235 SGTC_2084 5306078 60.6385 µM 1.18730140958735 0.279418142035231 no 1029 0.117554376151921 609 679340 SGTC_2973 9094665 17.96 µM 1.18677236892601 0.279515061837776 no 1030 0.117658710275573 697 25237061 YIL048W NEO1 SGTC_1242 0402-0103 60.1 µM 1.18621544138529 0.279617108126944 no 1031 0.117768614876101 589 432868 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.18234671887018 0.280326476015205 no 1032 0.118534077594419 619 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1615 st002656 86.5 µM 1.18099821735368 0.280573941554866 no 1033 0.11880171573677 645 1584458 SGTC_1557 sumaresinolic acid 42.3 µM 1.17794455525729 0.281134714083634 no 1034 0.119409355419928 597 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_67 0335-0847 266 µM 1.17792516690384 0.281138276277099 no 1035 0.119413220447232 790 4552207 YOR254C SEC63 SGTC_2043 5101342 149 µM 1.17727583750747 0.281257589194853 no 1036 0.119542713875725 631 678451 SGTC_2858 9025781 8.96 µM 1.17466978979991 0.281736690809382 no 1037 0.120063425096977 761 4894980 YPL153C RAD53 SGTC_2627 acetyl isogambogic acid 100 µM 1.17326114696703 0.281995822538388 no 1038 0.120345548909916 607 6857789 A caspase activator and apoptosis inducer. SGTC_2635 hydroquinidine 100 µM 1.17079627122266 0.282449533206401 no 1039 0.120840338494801 645 442912 An experimental heart treatment. SGTC_3148 9097893 49.47 µM 1.17029605825372 0.282541650441712 no 1040 0.120940923807943 611 17174100 SGTC_858 0438-0351 2.77 µM 1.16980071071439 0.282632885910267 no 1041 0.121040588799296 690 2799119 SGTC_3147 9097027 49.47 µM 1.16932103587518 0.282721248198949 no 1042 0.121137155465199 676 25236841 SGTC_3356 9151811 4.48 µM 1.16116519202188 0.284225687697868 no 1043 0.122787363577539 645 1859254 YPR165W RHO1 SGTC_2414 st077232 92.9 µM 1.16091377727502 0.28427212479467 no 1044 0.122838482722234 613 729801 SGTC_3035 9091303 49.47 µM 1.15967840004887 0.284500355542673 no 1045 0.123089883811975 646 25237002 SGTC_1091 telmisartan 47.6 µM 1.15742026246231 0.284917763034155 no 1046 0.12355034977451 664 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2298 7976326 193.81 µM 1.15664694927708 0.285060773928431 no 1047 0.123708316152801 583 2235818 SGTC_2704 st078022 71.1 µM 1.15496274917581 0.285372355976388 no 1048 0.124052840614553 661 54697681 SGTC_1308 1187-1617 41.4 µM 1.14763314734875 0.286730239783446 no 1049 0.125560019937607 702 2882570 SGTC_1281 0884-0031 11.8 µM 1.14731065424047 0.286790055221041 no 1050 0.125626626116734 689 1548255 SGTC_1791 st048313 56.1 µM 1.14665899409971 0.286910942011484 no 1051 0.125761292104571 611 1204976 SGTC_1928 4'-methoxychalcone 40.3 µM 1.14212334693406 0.28775299933088 no 1052 0.12670137608641 677 641818 SGTC_2330 7979373 200 µM 1.14119049481162 0.28792633095125 no 1053 0.126895329483059 667 1863007 SGTC_2539 epi(13)torulosol 80 µM 1.13994581048258 0.288157680310686 no 1054 0.127154439010085 640 6708597 SGTC_741 4582-0002 126 µM 1.13871494999876 0.288386546443824 no 1055 0.12741103258487 666 2912688 SGTC_3050 9093513 49.47 µM 1.13631654137775 0.288832752423666 no 1056 0.127912055191574 668 25236664 SGTC_613 3914-0030 117 µM 1.13549360440253 0.288985928538352 no 1057 0.128084280047701 424 1145395 SGTC_1440 4100-1550 40 µM 1.13537566856465 0.289007883475647 no 1058 0.128108974936472 652 742806 SGTC_2600 tangeritin 87.95 µM 1.1343544457727 0.2891980271319 no 1059 0.128322949711469 630 68077 A bioactive flavone. SGTC_2770 toltrazuril 17.5 µM 1.13427821486342 0.289212223086565 no 1060 0.128338932168934 712 68591 Kills coccidiodes. SGTC_575 k072-0246 11.9 µM 1.13037983650069 0.289938627447733 no 1061 0.129158103350971 701 6796779 SGTC_1735 st034310 56.75 µM 1.13013398235222 0.289984467347245 no 1062 0.129209886231066 675 871153 SGTC_2343 7990716 14.84 µM 1.12802861162458 0.290377156159849 no 1063 0.129653917985203 699 6456862 SGTC_930 2810-3379 265 µM 1.12779346727499 0.29042103018531 no 1064 0.129703576476059 768 1015764 SGTC_1132 3456-3614 2.5 µM 1.12725563444269 0.290521392513285 no 1065 0.129817207146363 785 3125502 SGTC_1010 4112-3296 15.2 µM 1.12319179333973 0.291280249959772 no 1066 0.13067802362841 716 704384 SGTC_228 caffeine 993.056 µM 1.12112521865825 0.291666504328119 no 1067 0.131117282721849 644 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3191 9110352 49.47 µM 1.11950626661696 0.291969262199919 no 1068 0.131462109481118 669 17122424 SGTC_2138 5575593 77.673 µM 1.11737385147978 0.292368265223428 no 1069 0.131917255330225 656 762213 SGTC_2875 9039966 71.43 µM 1.11690306637651 0.292456389487254 no 1070 0.132017886699859 650 6463691 SGTC_1040 k898-0338 155 µM 1.1148240570486 0.292845697991138 no 1071 0.132462912625948 753 20969351 SGTC_2696 st077691 74.316 µM 1.11446779741868 0.292912434143925 no 1072 0.132539276021007 611 757133 SGTC_2992 9074591 71.4286 µM 1.11397976084291 0.293003866801186 no 1073 0.132643934713461 670 17741321 SGTC_1230 0170-0365 3.77 µM 1.1137055908154 0.293055237805034 no 1074 0.132702755021295 831 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2244 6635614 200 µM 1.11303570843302 0.29318077066608 no 1075 0.132846546835361 551 836499 SGTC_3222 9128301 49.47 µM 1.11288472393168 0.293209067906237 no 1076 0.132878970820697 694 4911358 SGTC_1879 gemcitabine 100 µM 1.11280203319201 0.293224566190636 no 1077 0.132896731001093 702 60750 A nucleoside analog which inhibits DNA replication. SGTC_592 k241-0073 46.5 µM 1.10756424400724 0.294207030025933 no 1078 0.134025026324068 730 4230158 SGTC_59 0330-0160 1.33 µM 1.10740446099228 0.294237024773335 no 1079 0.134059549035502 830 4293482 SGTC_1700 st030840 7.9285 µM 1.10535231775389 0.294622382210937 no 1080 0.13450347817058 742 5499307 SGTC_2662 daunorubicin 22.37 µM 1.10527055688519 0.29463774032683 no 1081 0.134521185940672 662 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_233 rapamycin 362 pM 1.10519884714966 0.294651210722885 no 1082 0.134536718153486 729 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_146 3448-8650 53.125 µM 1.10420647798111 0.294837652586831 no 1083 0.134751790114232 841 2891488 YIL048W NEO1 SGTC_2028 5153890 36.43 µM 1.10203481595866 0.295245844294251 no 1084 0.13522326790182 691 2830968 YPR165W RHO1 SGTC_1216 1165-0504 9.65 µM 1.09944297517209 0.295733354185011 no 1085 0.135787447196066 732 6304004 SGTC_934 2950-0684 338 µM 1.09741649465624 0.296114780624208 no 1086 0.136229683070459 744 1121253 SGTC_2240 6690706 185.951 µM 1.09157188332333 0.297216122296261 no 1087 0.137510660086668 608 805876 SGTC_2358 9037157 4 µM 1.08872857198944 0.29775258375467 no 1088 0.138136799083065 718 2388925 SGTC_2670 beta-carotene 100 µM 1.08721633790989 0.298038084176825 no 1089 0.138470606026505 645 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2521 angolensin 13.4 µM 1.08291342499054 0.298851129141558 no 1090 0.139423426209448 678 821428 A flavenoid. SGTC_1287 0971-0001 34.6 µM 1.08231653872289 0.298963991678067 no 1091 0.139555949771797 762 4665869 SGTC_2098 5376439 882.5 nM 1.08195552380569 0.299032263756922 no 1092 0.139636145604484 756 2844116 SGTC_3145 9085516 49.47 µM 1.08175953938548 0.29906932963253 no 1093 0.139679694693068 688 25236195 SGTC_2673 kobusone 100 µM 1.08156247888451 0.299106601126657 no 1094 0.139723492204138 737 6710676 An epoxy ketone and protein crosslinker. SGTC_1521 st012942 49.4 µM 1.08029522816183 0.299346335888878 no 1095 0.140005366984908 778 24207259 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.07998488719376 0.299405058561595 no 1096 0.140074455035415 768 5393153 SGTC_330 1488-0319 80.1 µM 1.07989246941146 0.29942254685023 no 1097 0.140095033540771 719 6846614 SGTC_2551 apiole 73.87 µM 1.07879719842257 0.299629841090584 no 1098 0.140339072023718 579 10659 A possible DNA adduct former. SGTC_1633 st005664 67.9 µM 1.07720732653846 0.299930860604454 no 1099 0.140693826438542 734 2063822 SGTC_869 0564-0080 44.1 µM 1.07583930645899 0.300189985149206 no 1100 0.140999564898283 729 6843321 SGTC_2492 derrusnin 100 µM 1.07325106050344 0.300680516396199 no 1101 0.141579243330348 662 1715307 Part of coumarin class of compounds. SGTC_2132 5317594 122.667 µM 1.07282581035606 0.30076114552456 no 1102 0.141674639011246 666 794577 SGTC_1386 3228-0095 33.8 µM 1.07184511631868 0.300947126215771 no 1103 0.141894802482649 709 870181 SGTC_2727 riluzole 51.77 µM 1.07162081309312 0.30098967079348 no 1104 0.141945190556406 674 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1257 0669-0121 16 µM 1.07131662777035 0.301047371290843 no 1105 0.142013542909382 804 4307855 SGTC_3198 9112019 49.47 µM 1.07014800113244 0.301269092833208 no 1106 0.142276347868068 709 45595555 SGTC_959 1222-0044 107 µM 1.06884950620438 0.301515540284399 no 1107 0.142568743798495 732 6083612 SGTC_2806 7952793 58.44 µM 1.06543372333686 0.302164270499289 no 1108 0.143339851389208 748 2972490 SGTC_872 0588-0139 234 µM 1.05632066529111 0.303898092554866 no 1109 0.145410868874418 754 2047100 SGTC_443 clozapine 122 µM 1.05462223384658 0.30422172075006 no 1110 0.145799065475263 665 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1024 4507-0395 26 µM 1.04726882212152 0.305624646565156 no 1111 0.147487805724992 719 4201836 SGTC_574 1315-0397 40 µM 1.04437403308594 0.306177716209514 no 1112 0.148156186334285 873 6794277 SGTC_3108 9121785 49.47 µM 1.04423067608531 0.306205117062098 no 1113 0.148189338756756 742 17140271 SGTC_1644 st010134 20.9 µM 1.04389721782492 0.3062688575265 no 1114 0.148266472775016 723 3818134 SGTC_2753 fluvastatin 17.09 µM 1.04215418939584 0.306602132383274 no 1115 0.148670099105152 769 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1843 st055809 45.5 µM 1.0360669824664 0.307767287282301 no 1116 0.150085447235382 716 16413835 SGTC_1380 2291-0730 164 µM 1.0312627722466 0.308688234749338 no 1117 0.1512088055072 725 2999191 SGTC_1084 voriconazole 435 nM 1.02966299719169 0.308995172719809 no 1118 0.151584115714192 793 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_879 0831-1030 162 µM 1.02870455950673 0.309179125569027 no 1119 0.151809263360217 796 1549252 SGTC_2278 7948257 134.34 µM 1.02775904327027 0.309360645293964 no 1120 0.152031593237024 785 1247028 SGTC_1299 1079-1439 3.74 µM 1.02671992853663 0.309560187680389 no 1121 0.152276181295287 728 323161 SGTC_3041 9091929 49.47 µM 1.02562405355194 0.309770690640558 no 1122 0.152534412515974 792 25236887 SGTC_1023 4482-3888 16 µM 1.02320113143 0.310236323061397 no 1123 0.153106379047406 778 3303168 SGTC_867 0518-0118 155 µM 1.02269034033833 0.310334524764749 no 1124 0.153227140020401 788 6848158 SGTC_1677 st019204 53.9 µM 1.01633309446419 0.311557861344297 no 1125 0.154735397062069 740 3945625 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.01464763646724 0.311882547052843 no 1126 0.155136911600673 997 16725076 SGTC_537 1334-0398 209 µM 1.01368089542429 0.312068845536693 no 1127 0.155367521504288 816 5846986 SGTC_2694 st077685 81.9 µM 1.01285066743872 0.312228875272792 no 1128 0.155565747553094 750 2838096 SGTC_2405 ticlatone 3.52 µM 1.01187275728421 0.312417416779519 no 1129 0.155799448232502 757 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_3311 9131146 2.8755 µM 1.01019406177756 0.312741184520231 no 1130 0.15620116186526 788 4900406 YPR165W RHO1 SGTC_307 1501-1223 22.3 µM 1.00861751290591 0.313045382995831 no 1131 0.156579052537002 786 2830329 SGTC_958 1222-0007 33 µM 1.00843948598258 0.313079741674491 no 1132 0.156621762464753 845 7312461 SGTC_1445 4239-0156 97.7 µM 1.00554682235934 0.313638244625886 no 1133 0.157316807672792 881 4008346 SGTC_2893 9048488 25.97 µM 1.00415415058428 0.31390728816872 no 1134 0.157652158939231 763 6467338 SGTC_3277 9138724 49.47 µM 0.996990395950593 0.315292780668486 no 1135 0.159384585853269 719 15943418 SGTC_1834 st055981 52.8 µM 0.994963610470695 0.315685240319818 no 1136 0.159876981562106 819 471719 YDL150W RPC53 SGTC_2886 9058944 51.95 µM 0.99355634747174 0.315957860145952 no 1137 0.160219452559301 657 4949929 SGTC_650 1328-0195 38 µM 0.993010562575868 0.316063618426197 no 1138 0.160352403526175 812 2780821 SGTC_1978 st071761 42 µM 0.992787434459232 0.316106858926871 no 1139 0.160406777378184 769 5147680 SGTC_511 blebbistatin 171 µM 0.992602845285498 0.316142632780249 no 1140 0.160451768821339 798 3476986 A myosin inhibitor. SGTC_1241 0364-0022 50.8 µM 0.990467440002464 0.316556604843127 no 1141 0.160972848117351 822 4563895 SGTC_2739 tacrine 100.86 µM 0.987231702419626 0.317184326584067 no 1142 0.161764531784372 769 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2390 9097792 176.6 µM 0.986671861072541 0.31729298730336 no 1143 0.161901764479766 777 4497149 SGTC_2907 7721985 69.9 µM 0.985031052398781 0.317611545819535 no 1144 0.162304409129015 797 3267881 SGTC_728 3030-5151 22.5 µM 0.984375859141203 0.317738787553663 no 1145 0.162465371603519 783 3125388 SGTC_2572 astragaloside iv 100 µM 0.978918352088868 0.318799497444366 no 1146 0.163810161786832 810 45006101 An anti-inflammatory agent. SGTC_684 1140-0066 328 µM 0.975630163508308 0.319439301109156 no 1147 0.164623885644937 846 6813534 SGTC_2425 5628681 7.85 µM 0.97402811251049 0.319751217328455 no 1148 0.165021290480598 919 5714958 SGTC_2283 7944793 200 µM 0.973814487413118 0.319792819360421 no 1149 0.165074329227214 822 2970533 SGTC_2430 5571206 200 µM 0.967676335833238 0.320989149228953 no 1150 0.166603020054095 933 1731771 SGTC_2723 salbutamol 83.58 µM 0.966395629632885 0.321238994759397 no 1151 0.166923125061534 765 9884233 β2-adrenoceptor agonist SGTC_2433 5607874 27.82 µM 0.964204647638796 0.321666608308485 no 1152 0.167471667361319 825 2252428 SGTC_1635 st007035 42.4 µM 0.962685679590656 0.321963203795746 no 1153 0.167852642696443 947 3716403 SGTC_2313 7726885 200 µM 0.961594375388887 0.322176363183576 no 1154 0.168126698986161 805 726423 SGTC_2820 7989630 71.43 µM 0.961463964915496 0.322201839570863 no 1155 0.168159467865288 727 2984098 SGTC_1634 st006576 41 µM 0.960805884163468 0.322330411925865 no 1156 0.168324889725747 850 3915356 SGTC_1478 0453-0656 35.7 µM 0.958497796144738 0.322781521963001 no 1157 0.168905901130019 863 5258496 SGTC_1355 1499-0035 1.68 µM 0.956580211779704 0.323156507511701 no 1158 0.169389590310671 829 1548538 SGTC_2096 5468907 200 µM 0.951493226668703 0.324152142792121 no 1159 0.170677027642553 860 759785 SGTC_94 0334-0113 514.748 µM 0.948395735062385 0.324759007463275 no 1160 0.171464014912671 868 6795178 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.946827110817018 0.325066512054649 no 1161 0.171863442299773 1016 688664 SGTC_3016 9080866 49.47 µM 0.946091195825416 0.325210817930122 no 1162 0.172051036967307 877 17066299 SGTC_2585 alliin 100 µM 0.943433764067754 0.325732132965732 no 1163 0.172729539894967 862 87310 A garlic compound which reacts with lipids. SGTC_361 000s-0510 1.45 µM 0.943085797739675 0.325800419658662 no 1164 0.172818509756312 831 660 SGTC_716 1683-5115 658 µM 0.942183532421815 0.325977512043444 no 1165 0.173049341722769 952 723597 SGTC_2221 6807166 181.081 µM 0.941413088085833 0.326128762306137 no 1166 0.173246604521514 801 674925 SGTC_2942 9052777 62.25 µM 0.94110598141553 0.326189060120081 no 1167 0.173325275305829 918 6469503 SGTC_2469 5655019 90.81 µM 0.940620267219633 0.326284435296898 no 1168 0.173449745979206 924 2788239 SGTC_775 4577-0580 57.3 µM 0.93601685398672 0.327188928069343 no 1169 0.174632255078291 875 2006902 SGTC_1896 st058441 89 µM 0.935819572391527 0.32722771329878 no 1170 0.174683046229012 792 688759 SGTC_2280 7785178 200 µM 0.935711502296967 0.327248960488323 no 1171 0.174710873400544 851 2954328 SGTC_3024 9090631 49.47 µM 0.933482129492819 0.327687392537192 no 1172 0.175285546529401 838 25236383 SGTC_2794 7785382 27.27 µM 0.929220845961998 0.328526084367739 no 1173 0.17638732314592 949 2205081 SGTC_1703 st026983 48.3 µM 0.92855631269782 0.328656953661948 no 1174 0.176559535684557 919 1104023 SGTC_2643 anethole 100 µM 0.92730144013001 0.328904138232364 no 1175 0.176885023414416 922 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_3072 9116419 49.47 µM 0.927138728993237 0.328936194526642 no 1176 0.176927255041008 809 17170162 SGTC_1371 2421-0008 32.7 µM 0.927109896902547 0.328941874969646 no 1177 0.176934739066001 841 2827552 SGTC_816 0325-0417 81.3 µM 0.926654949791068 0.329031513003116 no 1178 0.177052857420487 864 68101 SGTC_321 4534-3890 65.3 µM 0.926020763109397 0.329156482937045 no 1179 0.177217595021962 900 699746 SGTC_2674 ligustilide 100 µM 0.924383350913601 0.32947923217668 no 1180 0.177643379957545 852 5319022 A signalling regulator. SGTC_382 3229-0966 23.2 µM 0.922743151891306 0.329802658129549 no 1181 0.178070536168163 915 5722370 SGTC_2742 clothiapine 36.27 µM 0.919175077437134 0.330506675497125 no 1182 0.179002002365994 843 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2127 5253358 187.912 µM 0.916296366130618 0.33107511214062 no 1183 0.179755736723382 790 20612 SGTC_1414 3917-0015 5.4 µM 0.916142265096936 0.331105552265111 no 1184 0.179796141216706 904 6618702 SGTC_887 0885-0007 9.62 µM 0.915205524743862 0.331290613925044 no 1185 0.180041872417616 910 5719458 SGTC_2785 7756463 72.73 µM 0.914652609343599 0.331399866783912 no 1186 0.18018701533185 905 2201551 SGTC_1704 st028805 70.8 µM 0.913554602237673 0.331616869119878 no 1187 0.180475465069511 868 2876101 SGTC_1988 st071872 53.4 µM 0.906176854612141 0.333076417632665 no 1188 0.182421125839218 932 16414116 SGTC_3193 9111931 49.47 µM 0.905314241046601 0.333247235246671 no 1189 0.182649466987018 898 17087244 SGTC_578 3460-0051 92 µM 0.903523385079258 0.333601976946093 no 1190 0.183124091373703 1010 2876744 SGTC_3242 9133940 49.47 µM 0.90338407174287 0.33362957907084 no 1191 0.183161045331791 926 17248444 SGTC_1301 naphtanilide LB 4.81 µM 0.897059079093246 0.334883695206187 no 1192 0.184843696424191 976 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_904 1141-0088 396 µM 0.896227420237229 0.335048733517888 no 1193 0.185065656878103 884 1378119 SGTC_281 1672-3440 14.9 µM 0.895997169604582 0.335094431172667 no 1194 0.185127137452816 975 6833000 SGTC_1477 0139-0234 16 µM 0.894637235947488 0.335364385861039 no 1195 0.185490520026293 938 620880 SGTC_1097 itavastatin 7.23 µM 0.892933378085033 0.335702731489038 no 1196 0.185946425568969 944 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_929 2805-0021 398 µM 0.892395807908786 0.335809507797067 no 1197 0.186090408641168 895 3098024 SGTC_2634 4'-methoxyflavone 100 µM 0.890354993289681 0.336214990659465 no 1198 0.186637650417465 846 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2913 7966556 36.57 µM 0.889316433767164 0.336421411913592 no 1199 0.186916520945373 899 2976516 SGTC_1397 3532-0190 20.1 µM 0.88840801533363 0.336602007115759 no 1200 0.1871606576992 871 5322280 SGTC_2568 diosmetin 100 µM 0.883770397775317 0.337524560395787 no 1201 0.188410084654436 940 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1911 st060208 74.3 µM 0.880238749704608 0.338227761002962 no 1202 0.189364992877033 943 688783 SGTC_3303 9125618 40.5795 µM 0.874682087689735 0.339335312768377 no 1203 0.190873454514775 982 22695467 SGTC_75 0159-0059 199.013 µM 0.870101477849573 0.340249363538159 no 1204 0.19212247507046 922 5377270 SGTC_3051 9093778 49.47 µM 0.869410108775234 0.340387406470856 no 1205 0.192311427953782 915 17217378 SGTC_3172 9105863 49.47 µM 0.868308208625276 0.340607462728216 no 1206 0.192612814821153 921 2348785 SGTC_36 0335-0881 14.2 µM 0.867059805528427 0.340856842095227 no 1207 0.192954621111372 962 23828853 SGTC_2648 atorvastatin 78.68 µM 0.866233607783305 0.341021920532177 no 1208 0.193181033337767 941 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_249 wiskostatin 11.211 µM 0.866116150820953 0.341045391492009 no 1209 0.193213234546641 972 2775510 A n-wasp and actin depolymerizer. SGTC_2720 fluspirilene 36.88 µM 0.865450436195753 0.341178430231189 no 1210 0.193395804278885 879 3396 An atypical antipsychotic. SGTC_1480 1070-0044 41.2 µM 0.861600821312932 0.341948137507412 no 1211 0.194453609448587 973 3124987 SGTC_2143 5623677 140.463 µM 0.858848223334538 0.342498906154375 no 1212 0.195212129121015 949 5375313 SGTC_1365 1672-3266 55.4 µM 0.857715849713131 0.342725580677228 no 1213 0.195524692944717 980 6415873 SGTC_606 k015-0008 38.6 µM 0.85393938763546 0.343481948440264 no 1214 0.196569287123595 1044 1970475 SGTC_378 3970-0959 8.33 µM 0.852608361871361 0.343748682245316 no 1215 0.19693826196794 953 6615653 SGTC_406 estrone 100 µM 0.851328531019552 0.344005230109806 no 1216 0.197293440131361 990 5870 A steroid. SGTC_1180 1193-0155 285 µM 0.844377191809075 0.345399909290568 no 1217 0.199229331733403 946 2921347 SGTC_3350 9150499 3.57 µM 0.844154300601331 0.345444663853749 no 1218 0.199291593836012 1026 4910996 YPR165W RHO1 SGTC_1994 st072947 40.9 µM 0.841916384185388 0.345894137147602 no 1219 0.199917379331041 955 5286565 YDL195W SEC31 SGTC_432 NS 1619 61.3 µM 0.839494386327338 0.346380826989142 no 1220 0.200595969023266 910 4552 A K+/calcium channel activator. SGTC_947 3447-0010 211 µM 0.836857920407262 0.346910901693282 no 1221 0.201336217849462 1010 748350 SGTC_369 0957-0393 4.5 µM 0.835900172506984 0.347103535993763 no 1222 0.201605532686159 964 6997992 SGTC_2826 7992541 19.48 µM 0.831510519451836 0.34798694313926 no 1223 0.202842644045723 1040 2985066 SGTC_1286 0929-0070 131 µM 0.831274640644936 0.348034436601553 no 1224 0.202909248589363 1007 1420408 SGTC_1489 4065-0444 182 µM 0.829284858379262 0.348435167863387 no 1225 0.203471618412535 988 2877968 SGTC_3173 9105693 49.47 µM 0.825686515086427 0.349160283996737 no 1226 0.204490971867808 1046 17096658 SGTC_1105 epirubicin 18.1 µM 0.819573240440704 0.350393455896717 no 1227 0.206229716859207 988 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3117 9124945 49.47 µM 0.817721920256859 0.350767216878676 no 1228 0.206757995443194 912 17592065 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.816808155525861 0.350951749105064 no 1229 0.207019035407767 1042 688751 SGTC_2136 5328288 199.296 µM 0.816094899751122 0.351095813545227 no 1230 0.207222930375595 920 262395 SGTC_2608 thymoquinone 42.66 µM 0.815910130093106 0.351133137081123 no 1231 0.207275768943228 964 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1261 0712-0010 12.7 µM 0.812345346661378 0.35185350531892 no 1232 0.208296748590237 1046 2840123 SGTC_2279 7948423 32.93 µM 0.811485244695185 0.352027393736417 no 1233 0.208543531534019 1000 1247112 SGTC_1417 3966-0327 90.4 µM 0.810516903991973 0.352223202016407 no 1234 0.208821576840568 1070 651118 SGTC_3046 9092212 49.47 µM 0.809042868579345 0.352521342082894 no 1235 0.209245244277589 1000 25236637 SGTC_424 splitomicin 100 mM 0.808848128742725 0.352560737163202 no 1236 0.209301254238758 948 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1662 st014054 52 µM 0.806262193480166 0.353084011175679 no 1237 0.210045842373295 1049 2838777 SGTC_358 0075-0058 9.45 µM 0.805349152551235 0.35326883498724 no 1238 0.210309112544524 1058 1069125 SGTC_2639 lactacystin 53 µM 0.80158552248992 0.354031058969894 no 1239 0.211396377480591 1037 3870 A proteasome inhibitor. SGTC_2510 benzyl isothiocyanate 8.31 µM 0.80153447081541 0.354041402170112 no 1240 0.211411148256059 997 2346 DNA damaging agent; causes G2/M arrest. SGTC_656 4090-1979 187 µM 0.799208868459618 0.354512689266674 no 1241 0.212084655225069 1081 22330961 SGTC_2757 clomiphene 4.22 µM 0.799087760029442 0.354537238197159 no 1242 0.212119763214159 1119 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1964 st076914 61 µM 0.797881167274801 0.354781850040015 no 1243 0.212469726582344 1082 24208661 SGTC_1976 st070609 63.5 µM 0.795872290333944 0.355189241296425 no 1244 0.213053134281259 1034 682556 SGTC_1996 st072960 66.8 µM 0.794699623342607 0.355427129483519 no 1245 0.213394125758199 1063 1719405 SGTC_2123 5259487 200 µM 0.788145151787221 0.356757810099274 no 1246 0.215305903563218 1065 2173474 SGTC_132 0417-1715 25.805 µM 0.783229660109824 0.357756893204033 no 1247 0.216746130240922 1087 6769098 SGTC_2636 apigenin dimethyl ether 100 µM 0.781654857973884 0.358077181373176 no 1248 0.217208718975802 1041 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1676 st018489 23.4 µM 0.780264645653032 0.358360010133308 no 1249 0.217617559078101 1024 3696235 SGTC_519 k048-0011 62.8 µM 0.771271906279572 0.36019139000711 no 1250 0.220272890381352 1058 6836379 SGTC_3333 9141820 12.094 µM 0.768352937303629 0.360786533594645 no 1251 0.221138766183093 1019 1939433 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.754484267849637 0.363618779047521 no 1252 0.225279244243393 1053 5711223 A potent inhibitor of glutathione S-transferases. SGTC_3163 9099914 49.47 µM 0.754401424698083 0.363635719785535 no 1253 0.225304108182924 1100 16268368 SGTC_2371 9071574 200 µM 0.746670392861506 0.36521782105485 no 1254 0.227631272842913 1100 45596039 SGTC_1210 3013-0140 750 nM 0.743488333700567 0.365869675852125 no 1255 0.228593041029572 1149 905973 SGTC_2567 aureobasidin a 60 nM 0.743060015547802 0.365957447793748 no 1256 0.228722673005466 1123 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1297 1068-0111 14.1 µM 0.738278019267845 0.366937860928241 no 1257 0.230172760406401 1113 767057 SGTC_2880 9042983 58.44 µM 0.737881053062708 0.367019286752772 no 1258 0.230293366753761 1152 6464714 SGTC_196 k015-0023 18.111 µM 0.735638195533655 0.367479454638052 no 1259 0.230975455662073 1132 5211998 SGTC_2617 dihydrotanshinone i 20.83 µM 0.725981984839224 0.369462789297216 no 1260 0.23392490729613 1183 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_547 1120-0019 610 nM 0.724887737000348 0.369687762449022 no 1261 0.234260452296111 1109 3676939 SGTC_599 1935-0052 86.5 µM 0.723888976010685 0.369893142819826 no 1262 0.234566949214754 1156 9557311 SGTC_3228 9131799 49.47 µM 0.722514938793537 0.370175753819272 no 1263 0.234988972061936 1097 17015818 SGTC_3267 9137951 49.47 µM 0.721800870207586 0.370322650631779 no 1264 0.235208457184967 1143 16643986 SGTC_2895 9054447 58.44 µM 0.720586457780922 0.370572520640704 no 1265 0.235581994134008 1182 2697450 SGTC_478 N-arachidonylglycine 10 µM 0.71836795286396 0.371029127459464 no 1266 0.236265220634535 1085 5283389 SGTC_2864 9034755 47.6 µM 0.716531443000238 0.371407250518466 no 1267 0.236831629729786 1181 4930451 SGTC_162 k030-0015 37.8 µM 0.715595162097107 0.371600071254279 no 1268 0.237120680880345 1222 1809920 YMR134W ERG29 SGTC_319 1348-1596 45.5 µM 0.713325920412007 0.372067539867814 no 1269 0.237822050781662 1187 5380505 SGTC_2786 7743617 45.45 µM 0.712027739558184 0.372335052751293 no 1270 0.238223799381913 1098 583674 SGTC_1526 st051518 75 µM 0.711224208985976 0.372500665167755 no 1271 0.238472654512713 1090 673993 SGTC_1661 st013063 9.66 µM 0.710741638392345 0.372600137162984 no 1272 0.238622176031558 1198 721395 SGTC_216 k038-0035 28.382 µM 0.710173210505309 0.37271731777185 no 1273 0.238798365693856 1126 4444231 YPR107C YTH1 SGTC_2258 7960471 200 µM 0.710090593786011 0.372734350073035 no 1274 0.238823979458293 1132 2974708 SGTC_1946 st076057 65.1 µM 0.707668197559339 0.373233862882482 no 1275 0.239575665584844 1071 953009 SGTC_2456 5770359 74.46 µM 0.704855918740786 0.373814039158966 no 1276 0.240449952548413 1188 3118787 SGTC_2265 7929201 200 µM 0.702821237334102 0.374233974635179 no 1277 0.241083580234799 1189 1265108 SGTC_2059 5238311 157 µM 0.700397544227673 0.374734392546056 no 1278 0.24183953474813 1191 703021 SGTC_1809 st050081 57.6 µM 0.700154410450025 0.374784603835364 no 1279 0.241915439558527 1241 5036894 SGTC_2724 maprotiline 69.64 µM 0.699316846113714 0.374957591463281 no 1280 0.242177020707728 1168 4011 A tricyclic antidepressant. SGTC_1974 st069448 26.9 µM 0.699278626970735 0.374965485712743 no 1281 0.242188960650558 1171 6323587 YNR016C ACC1 SGTC_1810 st050138 53 µM 0.697382932536425 0.375357111312726 no 1282 0.242781589879765 1194 3444541 SGTC_1332 1480-0653 17.5 µM 0.694234318421645 0.376007857460385 no 1283 0.243767636961312 1191 5749438 SGTC_503 tyrphostin 8 294 µM 0.691622193742936 0.376547991379778 no 1284 0.244587310188384 1177 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2025 5147754 141 µM 0.686547895487119 0.377597942643152 no 1285 0.246183836229899 1222 315777 YLR208W SEC13 SGTC_541 4513-1321 94 µM 0.685944961642114 0.377722759352373 no 1286 0.246373908023027 1173 747515 SGTC_64 000l-0018 272.079 µM 0.683580707776819 0.378212319865743 no 1287 0.24711998518862 1172 6811119 SGTC_3275 9138069 49.47 µM 0.681430601468781 0.378657707196746 no 1288 0.247799532559242 1227 17617007 SGTC_1236 0330-0013 258 µM 0.674870533276038 0.380017597397647 no 1289 0.249879011598489 1217 4617066 SGTC_1006 4099-6547 255 µM 0.673282247126727 0.380347070131008 no 1290 0.250383872394537 1239 3146833 SGTC_742 0kpi-0133 140 µM 0.672521588890458 0.380504891195116 no 1291 0.250625850468056 1239 2728852 SGTC_2665 lovastatin 100 µM 0.671798258069489 0.380654986033379 no 1292 0.250856068922027 1227 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1762 st045503 25.4615 µM 0.671135609654055 0.380792504731245 no 1293 0.251067071867124 1253 4645554 SGTC_3094 9117742 49.47 µM 0.670473489797914 0.380929928781172 no 1294 0.251278000253731 1202 17149698 SGTC_3336 9143619 71.43 µM 0.668356287088716 0.381369458366651 no 1295 0.251953095804049 1259 45595730 SGTC_1905 st060207 84.5 µM 0.668019409287108 0.381439408056202 no 1296 0.252060601541957 1179 1948547 SGTC_2199 6590217 200 µM 0.665678290027402 0.381925627579067 no 1297 0.252808376486142 1193 703109 SGTC_1370 2001-0092 44.6 µM 0.663970997020812 0.382280327291746 no 1298 0.253354437028913 1340 790957 SGTC_2706 st078239 82.5 µM 0.659172699947492 0.38327772865133 no 1299 0.254892437766362 1266 15434492 SGTC_1395 3486-0190 4.35 µM 0.655893497475382 0.383959808114947 no 1300 0.255946326173142 1298 6748079 SGTC_1602 st001878 87.6 µM 0.653911170751247 0.384372309849728 no 1301 0.256584518305979 1283 595405 YLR310C CDC25 SGTC_3177 9107506 49.47 µM 0.647110955436178 0.385788357148691 no 1302 0.258780067701758 1216 8897194 SGTC_1734 st037168 69.4 µM 0.646880067946082 0.38583646300155 no 1303 0.258854783413814 1264 708907 SGTC_593 1203-0218 61.7 µM 0.646284883627714 0.385960478894538 no 1304 0.259047437859164 1300 3666956 SGTC_232 clozapine 119 µM 0.644707140112532 0.386289282617719 no 1305 0.259558494182493 1257 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_551 k048-0028 34.9 µM 0.644531014928478 0.386325992398485 no 1306 0.259615576226628 1274 6836383 SGTC_562 3772-2733 112 µM 0.643678985896598 0.386503595213633 no 1307 0.259891809699558 1274 2876874 YIL048W NEO1 SGTC_482 fipronil 114 µM 0.641168944740897 0.387026943598211 no 1308 0.260706462055979 1303 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2854 9024559 71.43 µM 0.638480444627258 0.387587728888646 no 1309 0.26158048987743 1250 3163529 SGTC_218 alverine citrate 93.75 µM 0.638340490189267 0.387616927953125 no 1310 0.261626030030897 1297 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1031 k035-0009 16 µM 0.63483967264361 0.388347519173847 no 1311 0.262766492919805 1311 5180959 SGTC_2308 7584454 197.62 µM 0.634771267115869 0.388361798778156 no 1312 0.262788802721297 1351 893577 SGTC_3141 9094609 49.47 µM 0.634149907234681 0.388491514111105 no 1313 0.262991497596758 1255 25236309 YDL196W YDL196W SGTC_2151 5563267 85.4165 µM 0.6323567290573 0.38886592837897 no 1314 0.263576901092994 1290 5310824 SGTC_1556 plumbagin 1.48 µM 0.632072312943868 0.388925323747092 no 1315 0.263669813038159 1232 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_685 1278-0033 54.9 µM 0.631924792071163 0.388956131943142 no 1316 0.263718011160114 1359 3590572 SGTC_2108 5365811 200 µM 0.628635296569367 0.389643289821853 no 1317 0.264793923444149 1340 780283 SGTC_2918 7977171 22.06 µM 0.626872428720722 0.390011685593784 no 1318 0.265371430784953 1242 2236483 SGTC_1354 1498-1681 81 µM 0.623557689381017 0.390704651456847 no 1319 0.266459052329565 1341 5754243 SGTC_2768 sulfasalazine 50.2 µM 0.621591442323424 0.391115871267894 no 1320 0.26710527477096 1391 5384001 An antioxidant and salicylic acid derivative. SGTC_793 0488-0545 106 µM 0.61987664404187 0.391474602638896 no 1321 0.26766950182462 1285 292548 SGTC_1779 st039427 55 µM 0.619236430266209 0.391608557390867 no 1322 0.267880307860604 1414 1124498 SGTC_2983 9022671 12.99 µM 0.618948448008888 0.391668817380906 no 1323 0.267975160318759 1383 6405161 SGTC_1826 st055655 41.6 µM 0.617489310545277 0.391974180311566 no 1324 0.268456014892269 1353 676168 SGTC_2707 st078556 66.6 µM 0.613307266523437 0.392849751243565 no 1325 0.269836594773552 1309 17250899 SGTC_1248 0469-0687 58.6 µM 0.611906336242367 0.393143177616041 no 1326 0.270299864594314 1354 4017482 SGTC_376 3970-0862 59.1 µM 0.608876626456289 0.393777961069791 no 1327 0.271303109027469 1325 3135186 SGTC_750 4073-0104 132 µM 0.607154262438902 0.394138956016627 no 1328 0.271874271125251 1208 22330957 SGTC_453 enantio-paf c16 10 µM 0.607151983125264 0.394139433804491 no 1329 0.271875027376492 1307 13871343 A lipid and platelet activating factor SGTC_214 4373-3496 70 µM 0.603269522588009 0.394953502694257 no 1330 0.273164702252907 1398 3779166 SGTC_466 geldanamycin 89.2 µM 0.602384056937391 0.395139230270154 no 1331 0.273459259992112 1253 5288382 HSP90 inhibitor. SGTC_283 0987-0079 11.7 µM 0.600685540247016 0.395495563015427 no 1332 0.274024725866155 1352 411556 SGTC_963 1269-2853 151 µM 0.597681096561603 0.396126080719394 no 1333 0.27502637053954 1317 3668223 SGTC_1113 artemisinin 1.17947 µM 0.594637552352499 0.396765081300049 no 1334 0.276042886385314 1375 2240 An anti-malaria and mitochondrial poison. SGTC_667 1498-1044 59 µM 0.59447327660307 0.396799579354351 no 1335 0.276097805409369 1379 6739982 SGTC_2206 7254556 146.969 µM 0.593847554195734 0.396930989014874 no 1336 0.276307039775054 1336 4398905 SGTC_1399 3562-5772 25 µM 0.590417039913169 0.397651648236439 no 1337 0.277455544671308 1313 23847490 SGTC_1346 1488-2224 62.4 µM 0.58965631255945 0.397811504111572 no 1338 0.277710544999299 1357 3722427 SGTC_544 k015-0020 52.4 µM 0.58959966699096 0.397823408047054 no 1339 0.277729537508367 1364 3008304 SGTC_2831 7999036 19.48 µM 0.588340528591265 0.398088037615349 no 1340 0.278151873629205 1470 2988270 SGTC_3104 9120930 49.47 µM 0.587480540876836 0.398268805764265 no 1341 0.278440507831908 1346 17014836 SGTC_293 4049-0273 38.5 µM 0.582687955543719 0.39927659900242 no 1342 0.280051691408989 1304 1380311 SGTC_340 k038-0059 454 µM 0.580634436819216 0.399708622458423 no 1343 0.280743428895336 1393 23733424 SGTC_808 0711-0032 135 µM 0.579626077580599 0.399920808122859 no 1344 0.281083401708689 1358 4252555 SGTC_2324 6149169 200 µM 0.578428980694617 0.400172747583466 no 1345 0.281487266291337 1313 2888231 SGTC_111 0083-0039 52.457 µM 0.576259842323244 0.400629367427891 no 1346 0.282219780951925 1301 759313 SGTC_2812 7970281 58.44 µM 0.573983316967783 0.401108739110254 no 1347 0.282989545355942 1471 2233435 SGTC_1954 st077032 68.9 µM 0.572106449298023 0.401504066249721 no 1348 0.283624930081436 1299 698907 SGTC_3078 9116413 49.47 µM 0.568821216060723 0.402196281798625 no 1349 0.28473873757643 1302 17177322 SGTC_841 0251-0215 91.2 µM 0.565192610537659 0.402961204225857 no 1350 0.28597138113259 1413 3888614 SGTC_2922 7999257 32.47 µM 0.563206393895123 0.403380063007903 no 1351 0.286647174756332 1375 2988377 SGTC_2712 st079126 47.7 µM 0.562792796036576 0.403467297614352 no 1352 0.286787993187107 1337 3152970 SGTC_717 1532-0246 73.2 µM 0.558500475189449 0.40437290165334 no 1353 0.288251340061688 1367 9561992 SGTC_538 2922-0838 53.3 µM 0.558403635904011 0.404393338966669 no 1354 0.28828439529406 1503 777039 SGTC_3175 9106517 49.47 µM 0.554986159092333 0.405114742311406 no 1355 0.28945206380027 1363 41468073 SGTC_2514 salinomycin 42.74 µM 0.554703649504456 0.405174392401942 no 1356 0.289548689767788 1491 23682228 A polyether potassium ionophore. SGTC_49 0717-0965 32.132 µM 0.554331616389152 0.405252948172508 no 1357 0.28967595831897 1480 5889349 YGL099W LSG1 SGTC_1793 st048256 72.231 µM 0.55386179453634 0.405352157745939 no 1358 0.289836716855678 1345 672022 SGTC_2482 5981709 142.65 µM 0.552388635347398 0.405663275686116 no 1359 0.290341057607345 1433 877755 SGTC_69 0096-0274 206.684 µM 0.546035087068386 0.407005768291523 no 1360 0.292520909420448 1499 6741392 SGTC_2035 5154463 94.595 µM 0.545936765777241 0.407026552023551 no 1361 0.292554702355139 1469 2769623 SGTC_1825 st052143 62.6 µM 0.544914911716501 0.407242573026892 no 1362 0.292906019979258 1477 674173 SGTC_2546 rhodinyl acetate 100 µM 0.543616480239304 0.407517103479155 no 1363 0.293352708308954 1430 6708682 SGTC_2170 morpholine 200 µM 0.541470105342941 0.407971016176758 no 1364 0.294091798769175 1506 121171 Reacts with secondary amines. SGTC_2082 5219693 150 µM 0.537344703292645 0.408843797513641 no 1365 0.295514765973317 1402 2834649 SGTC_1667 st014849 34.6 µM 0.536211117550965 0.409083701397021 no 1366 0.295906325392287 1453 5348460 SGTC_1863 st057641 20.1 µM 0.533944071940928 0.40956358460944 no 1367 0.296690114561358 1420 3921635 SGTC_3224 9130643 49.47 µM 0.530823973830554 0.410224261575828 no 1368 0.297770382659321 1480 17644395 SGTC_420 mitomycin C 81.9 mM 0.528175089786808 0.410785359680661 no 1369 0.298688908551628 1408 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_353 1988-1175 58.3 µM 0.526572108950624 0.411124998798742 no 1370 0.29924538237432 1375 2788357 SGTC_2969 9091408 28.7 µM 0.523913232002163 0.411688507685262 no 1371 0.30016944554408 1398 4286311 SGTC_1394 3474-0001 65.7 µM 0.522341589928469 0.4120216792808 no 1372 0.300716258340287 1403 5017666 YIL048W NEO1 SGTC_3354 9151612 71.43 µM 0.522134218414005 0.412065644603207 no 1373 0.300788441530171 1519 27261949 SGTC_945 3381-0768 11.3 µM 0.518624486395224 0.412809918132146 no 1374 0.302011315062919 1453 1126236 YIL048W NEO1 SGTC_282 k297-0036 65.7 µM 0.515512823882729 0.41347003939301 no 1375 0.303097355360719 1480 5061378 SGTC_1340 1486-1359 257 µM 0.514988226665534 0.413581353818996 no 1376 0.303280623563571 1484 4309068 SGTC_878 0828-0289 13.7 µM 0.514577934808097 0.413668418600479 no 1377 0.303423993664524 1455 745350 YLR208W SEC13 SGTC_1702 st027038 51 µM 0.510633708873094 0.414505607425548 no 1378 0.304803783708398 1488 5521182 SGTC_2155 5570423 76 µM 0.510194871702916 0.414598777692836 no 1379 0.304957472315034 1460 797402 SGTC_1211 1056-0033 32.3 µM 0.509284394681157 0.414792097940849 no 1380 0.305276447355384 1477 6741922 SGTC_2157 5649910 96.377 µM 0.506946564087309 0.415288580495721 no 1381 0.306096156281716 1432 2858091 SGTC_1646 st011709 75.6 µM 0.506462508763242 0.415391395733946 no 1382 0.306266001224919 1514 5757843 SGTC_476 mead acid 10 µM 0.502281117408022 0.416279780017344 no 1383 0.30773489489485 1494 5312531 An omega 9 fatty acid. SGTC_1955 wogonin 32.4 µM 0.501591863991409 0.41642626096611 no 1384 0.307977321823189 1558 5281703 A flavanone. SGTC_1120 ficusin 1.78878 µM 0.497107247931015 0.417379619429933 no 1385 0.309556711883646 1599 6199 A DNA cross-linker. SGTC_3229 9132204 49.47 µM 0.494316476725965 0.417973138902574 no 1386 0.310541345246074 1526 17682924 SGTC_655 k060-0012 42 µM 0.493937058827035 0.418053845004146 no 1387 0.310675315670757 1449 5994525 SGTC_1923 st058458 19.1 µM 0.491172777075448 0.418641940198077 no 1388 0.311652125678246 1611 3534982 SGTC_141 0443-0274 32.331 µM 0.486559102236858 0.41962389442687 no 1389 0.313285406102897 1559 1627241 SGTC_3189 9110682 49.47 µM 0.486385811467743 0.419660786665268 no 1390 0.313346824208435 1515 17122418 SGTC_2458 5808907 16.39 µM 0.485818255553483 0.419781619786254 no 1391 0.313548014892419 1526 2731747 SGTC_504 lovastatin 124 µM 0.484650922898447 0.420030169631984 no 1392 0.313961992449831 1460 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_3230 9131665 49.47 µM 0.483163608731153 0.420346896518871 no 1393 0.314489786143318 1492 15943720 SGTC_2004 4023728 41.89 µM 0.480921826656645 0.420824386445442 no 1394 0.315286029698381 1562 360084 YDR527W RBA50 SGTC_840 0245-0196 390 µM 0.477341865757514 0.421587144000378 no 1395 0.316559351745864 1580 3827528 SGTC_622 1348-1566 26.3 µM 0.475358239843942 0.422009908382919 no 1396 0.317265827138871 1601 7340407 SGTC_1066 ketoconazole 628 nM 0.473908556581389 0.422318932010705 no 1397 0.317782558609054 1595 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1749 st037932 54.2 µM 0.470732453345965 0.42299613712273 no 1398 0.318915902953113 1500 594497 SGTC_2031 5180455 200 µM 0.469096641840141 0.423345011913603 no 1399 0.319500279667025 1496 29949 SGTC_1590 st077108 57.8 µM 0.46663724386742 0.423869648684978 no 1400 0.320379717963551 1564 5489485 SGTC_2088 5278280 127.392 µM 0.462426249005194 0.424768247565409 no 1401 0.321887839626607 1562 791502 SGTC_2958 9077254 16.72 µM 0.46065657687615 0.425146001059768 no 1402 0.322522506782012 1530 16457351 SGTC_2619 obliquin 87.91 µM 0.460278291938363 0.425226758537749 no 1403 0.322658240369408 1606 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1039 k821-0043 94 µM 0.45754447527188 0.425810475527826 no 1404 0.323639871247816 1646 15992768 SGTC_2186 6124449 200 µM 0.456794143397117 0.425970712813447 no 1405 0.323909507858974 1579 3834182 YLR033W RSC58 SGTC_631 k072-0230 41.5 µM 0.456641544288015 0.426003302645868 no 1406 0.323964356650399 1581 5773147 SGTC_3045 9092950 49.47 µM 0.453790469075179 0.42661228528816 no 1407 0.32498982207541 1666 44120432 SGTC_1939 st074455 53.6 µM 0.453144574102319 0.426750271227686 no 1408 0.325222320155257 1673 1644229 SGTC_1306 1185-0270 9.02 µM 0.452997184868208 0.426781760021712 no 1409 0.325275384317709 1629 1548076 SGTC_3112 9123419 49.47 µM 0.451869729751746 0.427022649224493 no 1410 0.325681416194423 1561 17015854 SGTC_200 k038-0079 37.545 µM 0.449889356740454 0.427445836539484 no 1411 0.326395111159184 1590 3436683 SGTC_3022 9087993 49.47 µM 0.448157845621836 0.42781591281372 no 1412 0.327019641588992 1605 17173644 SGTC_1322 1348-1070 12 µM 0.446682288289105 0.428131334161543 no 1413 0.327552235950281 1542 6758089 SGTC_2655 perillic acid 100 µM 0.446059918297 0.42826438837344 no 1414 0.327776982344892 1530 5702197 An apoptosis inducer. SGTC_1621 st003705 32.4 µM 0.446038889387759 0.428268884209812 no 1415 0.327784577264514 1655 24207032 SGTC_3138 9097216 49.47 µM 0.442460884526952 0.429033972166727 no 1416 0.329077864732227 1540 25237486 SGTC_1613 st002381 52.1 µM 0.441184338877087 0.429307001758182 no 1417 0.329539775070771 1549 551167 SGTC_3247 9135149 49.47 µM 0.438292151961231 0.429925712169126 no 1418 0.330587257142804 1564 8934436 YOR116C RPO31 SGTC_1514 1189-1591 158 µM 0.434834504711496 0.430665614322571 no 1419 0.331841278741523 1641 767698 YMR146C TIF34 SGTC_1785 bathophenanthroline 24 µM 0.434533051980853 0.430730133786982 no 1420 0.331950699398566 1518 72812 An iron chelator. SGTC_1442 4112-3290 3 µM 0.428663933734607 0.431986658505739 no 1421 0.334083905539181 1570 704353 SGTC_535 2293-4129 48.2 µM 0.425662326150935 0.432629542177865 no 1422 0.335176958864975 1694 396118 YIL048W NEO1 SGTC_1218 1348-1416 30.7 µM 0.423895418776679 0.433008061541045 no 1423 0.335821042680592 1588 6787668 SGTC_1574 spiramycin 23.7 µM 0.420481352929725 0.43373962065867 no 1424 0.33706692436889 1529 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1642 st009582 77.7 µM 0.419807898560937 0.43388395398648 no 1425 0.337312897163588 1696 6739311 SGTC_306 1672-3436 11.6 µM 0.419313402975489 0.43398993885744 no 1426 0.337493551256204 1643 6797378 SGTC_2764 methyldopa 94.69 µM 0.41846617852906 0.434171534869232 no 1427 0.337803154854227 1695 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2104 5389443 200 µM 0.415332086817853 0.434843423663859 no 1428 0.338949407545017 1688 2244536 SGTC_1919 st067113 52.3 µM 0.414568472405242 0.435007156448781 no 1429 0.33922891600087 1580 1268243 SGTC_2295 7971645 200 µM 0.414406470133166 0.435041894109258 no 1430 0.339288225643138 1660 2978226 YKL099C UTP11 SGTC_16 erodoxin 22.806 µM 0.414103205159139 0.435106923654061 no 1431 0.339399262795742 1614 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2990 9074105 71.4286 µM 0.413177181006845 0.43530550320107 no 1432 0.339738402676274 1608 6502001 SGTC_2919 7978188 46.38 µM 0.412917085035228 0.435361281940749 no 1433 0.339833681557395 1736 2980291 SGTC_2790 5423970 71.43 µM 0.408321626585836 0.436347009583056 no 1434 0.341518781928982 1714 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2072 5231554 129 µM 0.407089095101542 0.436611455578731 no 1435 0.341971276169104 1756 789545 SGTC_1139 k015-0024 46.9 µM 0.406522406657327 0.436733051026116 no 1436 0.342179398423334 1710 2766652 SGTC_3039 9090270 49.47 µM 0.397509122754803 0.438667845103756 no 1437 0.345496030288935 1737 17173750 SGTC_833 3852-0053 558 µM 0.394256077672941 0.43936650728918 no 1438 0.346695993722546 1689 3123681 SGTC_2713 st079149 53.4 µM 0.394239202138783 0.439370132171606 no 1439 0.346702222691089 1653 3103253 SGTC_3293 9120939 62.045 µM 0.391103675982468 0.440043734383175 no 1440 0.347860301790508 1679 934087 SGTC_3251 9135047 49.47 µM 0.390927832272347 0.4400815158847 no 1441 0.347925290294693 1745 17682963 SGTC_719 2810-4230 27.3 µM 0.39071050289655 0.440128211684601 no 1442 0.348005617287807 1668 721079 SGTC_2463 5473429 200 µM 0.389213734644652 0.440449832720448 no 1443 0.348559022078799 1634 5399405 SGTC_396 dithiazanine 1.25 µM 0.388767537471741 0.440545717831627 no 1444 0.348724058395077 1600 10578 An antihelmenthic. SGTC_1990 st072050 59.8 µM 0.387932597160784 0.440725150885614 no 1445 0.349032957219167 1600 17233948 SGTC_2329 6138490 200 µM 0.386740859679884 0.440981282598335 no 1446 0.349474031869005 1655 720019 SGTC_589 1227-0070 34.1 µM 0.385458731525129 0.441256868906577 no 1447 0.34994878810248 1671 2841384 SGTC_1866 st057638 64 µM 0.382154515244527 0.441967222597602 no 1448 0.351173378759436 1656 688802 SGTC_387 norethindrone acetate 66.7 µM 0.382096328557852 0.44197973348448 no 1449 0.351194957489816 1634 541197 SGTC_1015 4130-4525 82 µM 0.381025674924062 0.442209948119488 no 1450 0.351592098592776 1604 1363237 SGTC_3005 9076496 71.4286 µM 0.379802533676243 0.442472974906667 no 1451 0.352046000717288 1700 21368410 SGTC_2557 derrustone 83.84 µM 0.378579886031409 0.442735920893391 no 1452 0.352499930450579 1596 629853 An antioxidant. SGTC_1631 benzylvanillin 81.9 µM 0.373956310692695 0.443730506912676 no 1453 0.354218410400243 1693 75506 SGTC_3234 9132280 49.47 µM 0.371981706200475 0.444155376218192 no 1454 0.354953234967324 1669 17612295 SGTC_3103 9120822 49.47 µM 0.371657783298812 0.444225079809623 no 1455 0.355073830474707 1773 17141819 SGTC_2187 6125751 200 µM 0.368029988102732 0.44500584698859 no 1456 0.356425436891341 1693 874498 SGTC_758 0868-0029 16 µM 0.36777741650105 0.445060212948397 no 1457 0.356519604821265 1794 762687 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.367534521821311 0.44511249692847 no 1458 0.356610173092221 1659 390807 SGTC_2792 7535235 81.82 µM 0.367042373349706 0.445218436637348 no 1459 0.356793705543621 1601 1281891 SGTC_972 1319-0219 195 µM 0.366169884973509 0.445406257793117 no 1460 0.357119156163255 1639 23903702 SGTC_2749 bexarotene 57.39 µM 0.365307570210546 0.445591900909489 no 1461 0.357440914060162 1605 82146 An retinoic acid receptor inhibitor. SGTC_580 1123-0028 41 µM 0.360349455083609 0.446659537167276 no 1462 0.359292910041537 1713 1677248 YPR107C YTH1 SGTC_142 0335-0849 62.6745 µM 0.359899812045244 0.446756378528477 no 1463 0.359461028796339 1706 3889043 YPR107C YTH1 SGTC_2277 7947813 106.88 µM 0.358072469286268 0.447149973022616 no 1464 0.360144540628617 1796 1246798 SGTC_165 k038-0023 64.381 µM 0.357847855218442 0.447198356632782 no 1465 0.360228587732438 1651 46368543 SGTC_2408 sulbentine 18.36 µM 0.357308520757128 0.447314536661157 no 1466 0.360430425910237 1744 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_914 3820-6779 408 µM 0.355096071726069 0.447791175683907 no 1467 0.361258809724354 1637 2893481 SGTC_3288 9119690 36.221 µM 0.354945203887825 0.447823680654814 no 1468 0.361315321319984 1641 17595618 YKL019W RAM2 SGTC_573 3702-0553 84.7 µM 0.354932798645381 0.447826353420605 no 1469 0.361319968170959 1698 1222756 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.354695896846296 0.447877395442936 no 1470 0.361408712591522 1638 5355888 SGTC_1487 3970-0795 2.82 µM 0.353915818536512 0.448045474447264 no 1471 0.36170098592443 1727 3765103 SGTC_814 3342-0569 96 µM 0.350537425499578 0.448773504736089 no 1472 0.36296770406836 1714 4346283 SGTC_2762 leflunomide 42.06 µM 0.349232197843559 0.449054822453098 no 1473 0.363457497859137 1713 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1403 3909-7815 62.9 µM 0.348898455453898 0.449126758579285 no 1474 0.363582772389066 1730 6615483 SGTC_2933 9026794 32.47 µM 0.348166706599023 0.449284488408762 no 1475 0.363857494842515 1750 17586027 SGTC_2691 st077356 60.2 µM 0.344916703644067 0.449985129106173 no 1476 0.365078496323929 1802 2839272 SGTC_731 3966-0296 387 µM 0.344897655581933 0.449989235978815 no 1477 0.365085656584384 1712 660956 SGTC_212 3807-4682 38.772 µM 0.3434940127419 0.450291884224017 no 1478 0.365613422146038 1801 3125501 YBL034C STU1 SGTC_785 1270-0111 65.3 µM 0.342554518103107 0.450494470722913 no 1479 0.365966811601982 1701 6741994 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.341654109129362 0.450688641149888 no 1480 0.366305605798006 1757 6708739 YPR165W RHO1 SGTC_2281 7943571 200 µM 0.339011701345261 0.451258536233637 no 1481 0.367300457602925 1889 1244024 SGTC_2328 6201408 200 µM 0.33669361594754 0.451758566628033 no 1482 0.368173938205979 1692 2890418 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.336259194788479 0.451852283443068 no 1483 0.368337708983202 1682 16623 A steroid. SGTC_1968 st069590 43.6 µM 0.336172687017057 0.451870945913534 no 1484 0.368370324075658 1804 6384066 SGTC_1249 0481-0015 10.2 µM 0.333449432715358 0.452458492412886 no 1485 0.369397527070125 1688 4227577 SGTC_835 0312-0010 67.2 µM 0.332076066500564 0.452754837960142 no 1486 0.369915910908898 1725 1626196 SGTC_496 calpeptin 138 µM 0.332057148385811 0.452758920303144 no 1487 0.369923053297557 1693 73364 A calpain inhibitor. SGTC_2525 harmine 47.85 µM 0.33136464542282 0.452908359061426 no 1488 0.370184533325651 1798 5280953 A monoamine oxidase inhibitor SGTC_888 0916-0002 6.97 µM 0.330488934724145 0.453097342702154 no 1489 0.370515276098476 1812 2802138 YIL048W NEO1 SGTC_292 k038-0015 474 µM 0.330428979669045 0.453110281753034 no 1490 0.370537923726089 1774 46368540 SGTC_516 3992-2719 87.3 µM 0.326927924997981 0.453865939026791 no 1491 0.371861199760849 1613 5350887 YDR037W KRS1 SGTC_776 4476-4378 112 µM 0.32632154432134 0.453996835484159 no 1492 0.372090544793535 1724 2892008 SGTC_3156 9099931 49.47 µM 0.324758296602868 0.454334309203615 no 1493 0.372682004797307 1752 18111053 SGTC_1681 tripelennamine 100 µM 0.324494421322696 0.454391277824515 no 1494 0.37278187255579 1703 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1771 st048882 4.1505 µM 0.324465382599935 0.45439754711626 no 1495 0.372792863240509 1668 4580403 SGTC_1498 4478-3555 97.6 µM 0.3244504477579 0.454400771466418 no 1496 0.372798515875872 1860 3437919 SGTC_634 1611-4317 11.2 µM 0.324065568097634 0.454483865901689 no 1497 0.372944197057733 1867 2843522 SGTC_709 3807-1509 243 µM 0.32243568330092 0.454835775477617 no 1498 0.373561327551421 1757 1886677 YPL242C IQG1 SGTC_2078 5212016 200 µM 0.321762513191414 0.45498113047042 no 1499 0.373816307675171 1867 1899708 SGTC_3345 9148410 3.559 µM 0.319855925865217 0.455392845074205 no 1500 0.37453877503045 1842 4903596 SGTC_1488 4013-0813 75.9 µM 0.316221348942777 0.456177839677306 no 1501 0.375917252212825 1753 2910057 SGTC_3070 9117005 49.47 µM 0.316089339330286 0.456206354303593 no 1502 0.375967349111685 1819 8779016 SGTC_1194 1488-0194 225 µM 0.314361616150395 0.456579570447443 no 1503 0.376623202679071 1762 1391452 SGTC_924 2046-0044 21.3 µM 0.311449909770008 0.457208632617955 no 1504 0.37772930834154 1688 3623589 SGTC_1452 4194-0072 190 µM 0.303725974378344 0.458877872407063 no 1505 0.380668333786334 1913 1343545 SGTC_1192 1488-0095 21.4 µM 0.302917927105444 0.459052544024459 no 1506 0.380976204490161 1783 915875 SGTC_687 k029-0044 34.9 µM 0.30259083332412 0.459123252533185 no 1507 0.381100850559787 1908 5829338 SGTC_991 3996-0057 64.7 µM 0.301354849028942 0.45939044935632 no 1508 0.38157196005566 1780 715343 SGTC_385 1494-0393 12.4 µM 0.299287023602493 0.459837515723766 no 1509 0.382360527381735 1821 3090647 SGTC_3201 9113999 49.47 µM 0.291659414993793 0.461487048784307 no 1510 0.385273521384514 1844 16649224 SGTC_2656 pseudo-anisatin 100 µM 0.28651564445015 0.462599807374694 no 1511 0.387241606477329 1828 6708809 A neurotoxin. SGTC_1969 st069479 40.1 µM 0.284549071557114 0.463025316487022 no 1512 0.387994816884257 1891 3895485 SGTC_1349 flufenamic acid 69 µM 0.284285145198684 0.463082425696873 no 1513 0.388095934569328 1788 3371 A non-steroidal anti-inflammatory. SGTC_3254 9136651 49.47 µM 0.283841468323919 0.463178431598988 no 1514 0.388265936877779 1794 16454030 SGTC_2235 salicylic acid 500 µM 0.280094519023112 0.463989307655088 no 1515 0.38970249483205 1866 338 A COX inhibitor and kinase inhibitor. SGTC_1070 indatraline 8.81 µM 0.278754426523187 0.464279353125832 no 1516 0.390216645473967 1779 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_3245 9134821 49.47 µM 0.278387147379923 0.464358849207155 no 1517 0.390357592312447 1738 17014901 SGTC_2732 terfenadine 20 µM 0.278300323238231 0.46437764214862 no 1518 0.390390914003306 1856 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1268 0828-0275 2.46 µM 0.275849356938394 0.464908182369094 no 1519 0.391331886240919 1881 745337 SGTC_735 3076-0345 636 µM 0.275458264193039 0.464992844748165 no 1520 0.391482093141594 1916 2888990 SGTC_827 3253-0474 693 µM 0.273352512376902 0.465448717621286 no 1521 0.39229112635981 1945 5402065 SGTC_2315 7733312 200 µM 0.27148102819984 0.465853912121089 no 1522 0.393010544650562 1781 726316 SGTC_2904 7225135 42.03 µM 0.271178515303639 0.465919412435656 no 1523 0.393126868190884 1951 4446116 SGTC_662 k832-1615 104 µM 0.271055755077413 0.465945992833473 no 1524 0.393174075195681 1873 5878478 SGTC_1028 k015-0029 4.8 µM 0.270406092139637 0.466086662250648 no 1525 0.393423926886505 1779 4588309 SGTC_46 0329-0187a 2.197 µM 0.26933840060066 0.466317855245885 no 1526 0.393834642100649 1875 46494817 SGTC_1147 3809-1045 12.3 µM 0.267841273756377 0.466642055304568 no 1527 0.394410749582068 1820 325925 SGTC_1142 3253-1408 9.78 µM 0.26492623802734 0.467273364230442 no 1528 0.395533142636721 1953 256655 SGTC_1831 st055328 12 µM 0.260759231227212 0.468175954950762 no 1529 0.397139092868393 1948 1103068 SGTC_3089 9117425 49.47 µM 0.260049191820258 0.46832976883414 no 1530 0.397412914452601 1784 9401657 SGTC_554 4483-2211 187 µM 0.259948402418761 0.468351602948629 no 1531 0.397451787260691 1854 747107 SGTC_159 3970-0959 50 µM 0.259295522423372 0.468493039334244 no 1532 0.397703616945892 1937 6615653 SGTC_2580 diallyl disulphide 81.36 µM 0.258975648487075 0.468562336543676 no 1533 0.39782701468703 1836 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2450 5739737 12.93 µM 0.258743042280386 0.468612728746871 no 1534 0.397916753583906 1845 2262825 SGTC_2592 piperlongumine 83.33 µM 0.258484837672562 0.468668667220011 no 1535 0.398016374605593 1779 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_13 0199-0087 65 µM 0.256160180658294 0.469172317882068 no 1536 0.398913577120828 1901 4589825 SGTC_704 1310-0270 142 µM 0.255497637519024 0.469315870832601 no 1537 0.399169384031823 1794 5718033 SGTC_2963 9082507 9 µM 0.252142726474832 0.470042838885215 no 1538 0.400465372812894 1887 16459611 SGTC_3143 9086658 49.47 µM 0.251321025284072 0.470220906767012 no 1539 0.400782960444673 1826 25236626 SGTC_2159 5658611 73.75 µM 0.250798474486197 0.470334149953234 no 1540 0.400984960537524 1954 793844 SGTC_572 0960-0087 17.7 µM 0.250399806422206 0.470420547840996 no 1541 0.401139089650456 1788 6796365 SGTC_2496 diffractaic acid 79.83 µM 0.24974018951336 0.470563500665929 no 1542 0.401394138010195 1986 94870 An apoptosis inducer which activates caspases. SGTC_604 1000-0114 314 µM 0.249544281642947 0.47060595874368 no 1543 0.401469896108138 1975 1572745 SGTC_1861 st057647 17.4 µM 0.248958472138351 0.470732920134282 no 1544 0.401696452296907 1979 688668 SGTC_1724 st037281 8.293 µM 0.248051463043775 0.47092950037123 no 1545 0.402047294497822 1808 574124 YDL195W SEC31 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.247313086267503 0.471089537386055 no 1546 0.402332965961509 1961 140250 A respiratory chain inhibitor. SGTC_856 0433-0016 11.3 µM 0.245974846786278 0.471379601526073 no 1547 0.402850851879646 1874 3911780 SGTC_1721 st082152 9.2685 µM 0.245894047682001 0.471397115263715 no 1548 0.402882125829255 1877 5296051 SGTC_925 2064-1272 59.6 µM 0.245517005684868 0.471478842328911 no 1549 0.403028071208622 1808 6815817 SGTC_2499 avocadenofuran 51.48 µM 0.244334333678734 0.471735204338831 no 1550 0.403485947338933 1778 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1133 3473-0247 50 µM 0.244047621261634 0.471797355350955 no 1551 0.40359696913347 1764 711311 SGTC_1092 toremifene 6.32 µM 0.243134310050397 0.47199533954465 no 1552 0.40395067647203 1969 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1009 4106-0057 9.87 µM 0.242823198261983 0.472062782778912 no 1553 0.404071181854699 2014 2928005 SGTC_1525 8-methoxypsoralen 92.5 µM 0.242634426050636 0.472103705464811 no 1554 0.404144304922684 2021 4114 Related to psoralen; DNA damaging agent. SGTC_1254 0550-0035 264 µM 0.242427149076676 0.472148640015661 no 1555 0.404224599879203 1941 15121435 SGTC_913 3487-1245 167 µM 0.240191045439689 0.472633416294384 no 1556 0.405091077613646 1815 4016153 SGTC_2784 7567673 72.73 µM 0.23790035291962 0.473130069205261 no 1557 0.405979190890469 1890 3471247 SGTC_11 0438-0307 1.3 µM 0.23789277534772 0.47313171219439 no 1558 0.40598212955988 2016 4011476 SGTC_2819 7996655 46.38 µM 0.236578003043039 0.473416791489763 no 1559 0.406492093420238 1964 6456960 SGTC_644 1498-1197 63.3 µM 0.236025550501968 0.473536582675506 no 1560 0.406706421885164 1942 6741615 SGTC_2026 5148700 152 µM 0.235476628371631 0.473655610713978 no 1561 0.406919408380007 1869 79838 SGTC_942 3253-1115 227 µM 0.231298176699769 0.474561740704891 no 1562 0.408541581534352 1991 46497897 SGTC_2086 5274770 176.623 µM 0.230250217748911 0.474789019642441 no 1563 0.408948670908366 1893 689278 SGTC_993 3909-8757 62.7 µM 0.229554628351213 0.474939882013085 no 1564 0.409218933331917 1894 4288324 YLR208W SEC13 SGTC_3044 9093193 49.47 µM 0.227552889839906 0.475374047501249 no 1565 0.409996923771596 1824 25236277 SGTC_1075 aripiprazole 15.2 µM 0.227153286976525 0.475460722565579 no 1566 0.410152274909323 1878 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1062 mesoridazine 14.2 µM 0.226877017562128 0.475520646912654 no 1567 0.41025968671009 1919 4078 A neuroleptic. SGTC_2124 5246320 200 µM 0.226716682714738 0.475555424672036 no 1568 0.410322026972566 1913 579342 SGTC_193 1273-0060 1.558 µM 0.224794390224179 0.475972397898583 no 1569 0.411069615177202 2000 2847393 YHR072W ERG7 SGTC_932 2857-0803 154 µM 0.224504405336722 0.476035302137744 no 1570 0.411182419718379 2008 674898 SGTC_2006 4011487 200 µM 0.224502189706069 0.476035782760127 no 1571 0.411183281630194 1988 45595294 SGTC_2809 7964133 12.99 µM 0.223042735902864 0.476352380147595 no 1572 0.411751122864309 1914 1253665 SGTC_1960 st011366 51.8 µM 0.222307166328154 0.476511951955322 no 1573 0.412037386877809 1949 3972846 SGTC_244 nsc-207895 1.295 µM 0.22077084905826 0.476845247196125 no 1574 0.412635431311853 1894 42640 SGTC_2841 9004761 38.96 µM 0.220269989679171 0.47695390928506 no 1575 0.412830445479475 1785 2991039 SGTC_1096 rimcazole 32.2 µM 0.21975428392271 0.477065794105187 no 1576 0.413031262701159 1901 18528119 A dopamine reuptake inhibitor. SGTC_2846 9008642 19.48 µM 0.219624867566329 0.477093871884219 no 1577 0.413081661356102 1877 2992898 SGTC_3080 9117754 49.47 µM 0.219312967462808 0.47716154124897 no 1578 0.413203130602609 2019 9550191 SGTC_3209 9113616 49.47 µM 0.218693909271908 0.477295853106759 no 1579 0.413444246923119 2082 16649353 SGTC_3276 9139060 49.47 µM 0.218430404050874 0.477353024405477 no 1580 0.413546889203551 1935 4870619 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.216163754889551 0.477844826107156 no 1581 0.414430052513056 1902 6708760 SGTC_2975 9084847 53.72 µM 0.215043221223412 0.478087964184279 no 1582 0.414866810538103 1871 27211724 SGTC_252 miconazole 1.30953 nM 0.214758897257036 0.478149659287397 no 1583 0.41497765018626 1993 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1729 st035615 45.989 µM 0.214733937126956 0.478155075379939 no 1584 0.414987380860706 1885 17385451 SGTC_1398 3558-0053 112 µM 0.213990635173506 0.478316366134173 no 1585 0.415277180043439 1913 4532369 SGTC_2728 chlorpromazine 9.18 µM 0.212054461150262 0.478736517475648 no 1586 0.41603227322922 1992 2726 A thorazine and dopamine antagonist. SGTC_591 4299-0174 154 µM 0.211605120488662 0.478834028160999 no 1587 0.416207557110874 1964 5509088 SGTC_1331 1472-0049 76.2 µM 0.210755537910621 0.479018398150426 no 1588 0.416539017401847 1894 24051409 SGTC_2112 5488546 200 µM 0.210106949314658 0.47915915296923 no 1589 0.41679210088496 1946 600757 SGTC_964 1287-0107 19.4 µM 0.210073360281301 0.479166442434913 no 1590 0.416805208484187 2022 51516812 YPR165W RHO1 SGTC_1491 4138-0063 26.5 µM 0.209526026370972 0.479285225391147 no 1591 0.417018810075012 2037 23883227 SGTC_2871 9038510 12.99 µM 0.208949256883478 0.479410398476579 no 1592 0.417243925651398 2060 4945164 SGTC_1479 0549-0158 134 µM 0.20786244958945 0.479646267748776 no 1593 0.417668184817322 1927 5440202 SGTC_3225 9130819 49.47 µM 0.207333412438374 0.47976108701537 no 1594 0.417874740838256 2015 4547121 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.207271325753182 0.479774562072827 no 1595 0.417898983304223 2014 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2652 actinonin 100 µM 0.2066471941942 0.47991002248849 no 1596 0.41814270002282 1978 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1862 st057513 3.81 µM 0.203959657721754 0.480493346986304 no 1597 0.41919251233163 1938 5393163 SGTC_1573 oleylamine 1.06 µM 0.200720075234049 0.481196547397447 no 1598 0.420458730700757 1913 5356789 An amine of the fatty acid oleic acid. SGTC_2110 5483698 200 µM 0.198193936821699 0.481744924688142 no 1599 0.421446665555754 1937 2848765 YHR062C RPP1 SGTC_1776 st049249 45.9 µM 0.197088442442131 0.481984917719889 no 1600 0.421879163820478 1908 1822314 SGTC_2204 7233102 200 µM 0.196103337690016 0.482198780733995 no 1601 0.422264641942342 2014 2172480 SGTC_3327 9140648 26.9345 µM 0.190027495054112 0.48351793715338 no 1602 0.424643792566965 2060 8029710 SGTC_3307 9126885 69.2785 µM 0.189541730459171 0.483623411901953 no 1603 0.424834125818591 1898 24824909 SGTC_1129 3453-1384 223 µM 0.189158260816705 0.483706676013656 no 1604 0.424984390038259 1986 1084452 SGTC_545 4218-0007 221 µM 0.188620906546523 0.483823354830266 no 1605 0.42519497294162 1979 2840508 SGTC_2369 9071472 200 µM 0.188414169400924 0.483868245222719 no 1606 0.425275996519102 1990 17296037 SGTC_1794 st048918 76.9 µM 0.18787990724326 0.483984254531802 no 1607 0.425485396970007 2075 672303 SGTC_1745 st081495 74 µM 0.187343828641947 0.484100659624858 no 1608 0.42569553049108 1971 13842402 YBL026W LSM2 SGTC_1155 4088-0394 48.2 µM 0.186298775153146 0.484327588347424 no 1609 0.426105233968403 1915 2326248 SGTC_63 0099-0242 26.702 µM 0.186208658401757 0.484347157038447 no 1610 0.426140567142906 2093 3898502 YLR359W ADE13 SGTC_2467 5474540 200 µM 0.185670269228379 0.484464068066148 no 1611 0.426351672299599 2049 5413519 SGTC_261 5-fluorouridine 15.376 µM 0.182193808332846 0.485219012094783 no 1612 0.42771531595431 2067 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3113 9123498 49.47 µM 0.181506603535985 0.485368251011885 no 1613 0.42798497518411 2115 8897275 SGTC_5 0352-0601 109.883 µM 0.180053639679593 0.485683795043008 no 1614 0.42855522893777 2004 762456 SGTC_1993 st073995 70.8 µM 0.179959798652671 0.485704175059094 no 1615 0.428592064450681 2004 3098394 SGTC_2333 9017922 200 µM 0.179477269836398 0.485808969311491 no 1616 0.428781481789666 2077 3163164 SGTC_487 nimodipine 119 µM 0.177442929919945 0.486250792228487 no 1617 0.429580244546134 2102 4497 L-type voltage-gated calcium channels inhibitor SGTC_2176 5809774 33.9695 µM 0.176570235049727 0.486440331438841 no 1618 0.429922987838097 2116 2870539 SGTC_2095 5432005 200 µM 0.175916800489079 0.48658225185919 no 1619 0.430179653151087 1999 783734 SGTC_2018 5133068 143 µM 0.173837837607863 0.487033796104814 no 1620 0.430996453494594 2000 785362 SGTC_2388 9080168 200 µM 0.173175474322933 0.487177662861272 no 1621 0.431256750509342 1910 15943073 SGTC_1162 k048-0130 20.1 µM 0.172979979937632 0.487220124989782 no 1622 0.431333582044873 1958 6797406 SGTC_302 1094-0063 18.9 µM 0.171056864208422 0.487637840731726 no 1623 0.432089526630353 1988 5440289 SGTC_2071 5230951 39.92 µM 0.169736342459094 0.487924676240594 no 1624 0.432608745805683 2091 1799272 SGTC_1678 st019265 80.2 µM 0.168898783233863 0.488106608885007 no 1625 0.432938128143731 2128 5367020 SGTC_2653 dihydrofissinolide 100 µM 0.168830624426249 0.488121414290251 no 1626 0.432964934638786 2043 6857746 SGTC_172 1112-0046 2.638 µM 0.166857188583601 0.488550089564951 no 1627 0.433741209690737 2001 2802135 YIL048W NEO1 SGTC_3346 9158254 43.5805 µM 0.166707705462527 0.488582561253379 no 1628 0.433800021152127 2022 17639500 SGTC_1751 st044839 27.194 µM 0.165036384142696 0.488945621562165 no 1629 0.434457672147231 2134 5291326 SGTC_2334 9017922 200 µM 0.164770775008862 0.489003320555066 no 1630 0.434562203878635 2083 3163164 SGTC_853 0419-0306 21 µM 0.163378283064486 0.489305819096947 no 1631 0.43511030036936 1956 762713 SGTC_1805 st050013 60.3 µM 0.158900221803331 0.49027865334765 no 1632 0.436873742970965 2088 4037144 SGTC_1668 st014914 51.6 µM 0.157339695892012 0.490617682927682 no 1633 0.437488568523554 2100 2839556 SGTC_2431 5490079 200 µM 0.156101343601805 0.490886724024808 no 1634 0.437976569653131 2018 5722345 SGTC_452 diindolylmethane 8 µM 0.154443905173625 0.491246821118988 no 1635 0.438629868799445 2070 3071 Inhibits expression of several cancer promoting factors. SGTC_416 estradiol valerate 100 µM 0.154123793139213 0.491316369881031 no 1636 0.438756064105084 2022 13791 A steroid. SGTC_1429 4049-0205 9.46 µM 0.153323258896589 0.491490298156158 no 1637 0.43907167979035 2126 22774478 SGTC_351 caspofungin 25 nM 0.14929986973802 0.492364464650031 no 1638 0.440658509027506 2064 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1942 st076330 65.2 µM 0.1489374373792 0.492443212617862 no 1639 0.44080149994805 2099 24208414 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.14788822667346 0.492671182904468 no 1640 0.441215489894354 2042 15053 SGTC_82 0054-0107 293.755 µM 0.147488740147576 0.492757983126498 no 1641 0.441373133299586 2150 3104697 SGTC_786 4544-0069 423 µM 0.146945954077959 0.492875919946638 no 1642 0.441587339744281 2081 748821 YLR208W SEC13 SGTC_2248 tofa 1.1 µM 0.146300907448437 0.493016076799698 no 1643 0.441841924763166 2023 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2814 7977482 42.97 µM 0.145894344751891 0.493104415893263 no 1644 0.44200239802793 2113 6456762 SGTC_2860 9025725 38.96 µM 0.144715268848466 0.49336061074018 no 1645 0.442467841635042 1955 40546248 SGTC_1695 st026914 34.495 µM 0.144082281545451 0.493498150168082 no 1646 0.442717748000822 2021 3289191 SGTC_1614 st002383 48.6 µM 0.144067356071206 0.493501393277579 no 1647 0.442723640923732 2188 1947235 SGTC_1948 st076329 66.6 µM 0.143517284205372 0.493620916966284 no 1648 0.442940830864469 2159 24208413 SGTC_1897 st060201 15 µM 0.14314456857857 0.493701903704057 no 1649 0.443088003357103 1972 611878 SGTC_253 dyclonine 31.25 µM 0.142401388733187 0.493863388746539 no 1650 0.44338148275756 2082 3180 An oral anasthetic. SGTC_215 1287-0124 461.5 µM 0.142242064437235 0.493898008346111 no 1651 0.443444403473146 2173 5560863 SGTC_564 3555-0129 330 µM 0.14199305107954 0.493952116586977 no 1652 0.443542747253659 2172 563260 SGTC_2951 9072950 58.06 µM 0.141193690040128 0.49412581090627 no 1653 0.443858465379037 2179 16488155 SGTC_1384 3089-0840 101 µM 0.138923591632243 0.494619089843084 no 1654 0.444755264154115 2159 1069836 SGTC_2214 7179297 48.276 µM 0.136792081715684 0.495082261825277 no 1655 0.445597571341305 2100 769744 SGTC_1352 1496-0991 99 µM 0.13654493115732 0.495135967488447 no 1656 0.445695253606837 2084 3000039 SGTC_2769 toremifene 3.73 µM 0.132179324253247 0.49608462480368 no 1657 0.447421227237288 2112 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3059 1327-0034 3 µM 0.131845908004837 0.496157077967579 no 1658 0.447553087072168 2061 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2460 5552655 174.22 µM 0.130857623057791 0.496371838396401 no 1659 0.44794396912048 2037 5401989 SGTC_2047 4141938 200 µM 0.130240895693217 0.496505857602258 no 1660 0.448187920014313 2069 3807862 SGTC_2815 7968870 71.43 µM 0.129835857716087 0.496593875426744 no 1661 0.44834814633239 2098 2977326 YHR190W ERG9 SGTC_1982 st072467 71.9 µM 0.128304430369424 0.496926667667164 no 1662 0.4489540295792 2036 3163533 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.127781932673503 0.497040211379448 no 1663 0.449160774238429 2014 803109 SGTC_789 1309-1135 70.6 µM 0.125701680675714 0.497492272184835 no 1664 0.449984035717484 2190 3092424 SGTC_2911 7942208 15.64 µM 0.124480362491649 0.497757679107063 no 1665 0.450467473950463 2053 1243384 SGTC_419 nsc-638432 893 µM 0.124404855226866 0.497774087764751 no 1666 0.450497364649381 2070 368090 SGTC_1722 st034304 3.6505 µM 0.123122627798756 0.498052732113911 no 1667 0.451004996606047 2085 4036148 YLR033W RSC58 SGTC_1841 st054148 70 µM 0.122932213596704 0.498094111629225 no 1668 0.451080388163782 2064 675442 SGTC_1500 4488-1866 171 µM 0.121590608842178 0.498385660577308 no 1669 0.451611625679963 2186 2900003 SGTC_2109 5483026 200 µM 0.118663196915965 0.499021829758108 no 1670 0.452771097541348 2084 759335 SGTC_1832 st054113 55 µM 0.11851904326571 0.499053156520035 no 1671 0.452828203546801 2208 1251267 SGTC_318 1488-0629 67.2 µM 0.117960023321683 0.499174640036934 no 1672 0.453049666719157 2079 3662576 SGTC_678 1218-2179 85.9 µM 0.117157255561408 0.49934909378415 no 1673 0.45336771935178 2211 6820081 YOR116C RPO31 SGTC_2166 5933061 31.504 µM 0.115788492580029 0.499646547243148 no 1674 0.453910085379946 2154 2877375 SGTC_2793 7325131 81.82 µM 0.115343242233467 0.499743307110601 no 1675 0.454086532358123 2125 4176441 SGTC_2239 6685329 187.64 µM 0.11486493948981 0.499847249797802 no 1676 0.45427608767062 2057 805680 SGTC_2125 5246583 200 µM 0.114847464853322 0.499851047310597 no 1677 0.454283013210287 2199 835267 SGTC_449 xestospongin c 11.1929 µM 0.114217173471247 0.499988019527459 no 1678 0.454532819268108 2141 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1927 st060202 13.8 µM 0.11410691478406 0.499988019527459 no 1679 0.454576520412391 2215 688887 SGTC_615 k087-0205 167 µM 0.112951279732896 0.499736881892838 no 1680 0.455034590537327 2128 9642773 SGTC_1753 st043925 64 µM 0.112637768022114 0.499668750891246 no 1681 0.45515887051126 2195 670181 SGTC_2040 5100729 123 µM 0.110598813849578 0.499225654562124 no 1682 0.455967244063777 2137 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1214 0358-0031 63.7 µM 0.110570424739094 0.499219485174087 no 1683 0.455978500641291 2208 4301366 SGTC_1888 azatryptophan 97.5 µM 0.110525413881944 0.499209703626584 no 1684 0.455996347986621 2088 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2014 4013930 200 µM 0.1096498261279 0.499019425121054 no 1685 0.456343546663853 2236 64556 SGTC_766 1391-0721 126 µM 0.108183927115468 0.498700863542546 no 1686 0.456924897212533 2206 1020919 YIL115C NUP159 SGTC_2370 9071495 200 µM 0.107911470303299 0.498641654724948 no 1687 0.457032959135674 2052 21791103 SGTC_1222 0366-0074 1.18 µM 0.107872912374157 0.498633275530003 no 1688 0.457048252252824 2217 286520 SGTC_806 3966-4455 5.86 µM 0.103361301781883 0.497652842530743 no 1689 0.458838112150009 2055 714982 SGTC_3291 9121177 71.43 µM 0.103305907871248 0.497640804773043 no 1690 0.458860093452849 2128 17015612 SGTC_799 1310-0557 151 µM 0.102713023273572 0.497511964012866 no 1691 0.459095368619186 2129 5354492 SGTC_2452 5863136 48.41 µM 0.101107805276397 0.497163132700923 no 1692 0.459732441043089 2212 2184096 SGTC_1136 pergolide 1.05886 µM 0.0991530363503545 0.496738343129226 no 1693 0.460508381299166 2088 47811 A dopamine receptor agonist. SGTC_1932 st074806 40.9 µM 0.0990020236767645 0.496705526810465 no 1694 0.460568331669074 2162 17251235 SGTC_3127 9126946 49.47 µM 0.098152776682636 0.49652097874744 no 1695 0.46090549003641 2064 27243249 SGTC_1325 1431-0015 227 µM 0.0977681609109001 0.496437398952439 no 1696 0.461058195069822 2036 1103340 SGTC_1562 morin hydrate 59.1 µM 0.0972964558026093 0.496334894227233 no 1697 0.461245485254125 2147 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_421 streptovitacin 30 mM 0.0963187160899028 0.496122425522359 no 1698 0.461633723452725 2118 91467 include heat shock SGTC_1518 st038567 90.8 µM 0.0941352933633362 0.495647958725964 no 1699 0.46250084239989 2239 77966 SGTC_3252 9135871 49.47 µM 0.092864117379605 0.495371729715211 no 1700 0.463005756353088 2206 17682838 SGTC_3298 9116858 71.43 µM 0.0916460911477622 0.495107052328909 no 1701 0.463489615036774 2201 2506942 SGTC_472 calcifediol 10 µM 0.0909298494181296 0.494951413831014 no 1702 0.463774166014203 2142 5283731 A vitamin D metabolite. SGTC_2438 5259590 200 µM 0.0902886712762825 0.494812087214948 no 1703 0.464028911196768 2230 1201127 SGTC_2851 9015922 71.43 µM 0.090040908623773 0.494758249097869 no 1704 0.464127353228161 2214 2996893 SGTC_760 0568-0725 82.9 µM 0.0895061035381633 0.494642037806278 no 1705 0.464339851566409 2250 3916171 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.0894285649367439 0.494625188974429 no 1706 0.464370661438461 2232 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3185 9108267 49.47 µM 0.0887623915947987 0.494480432536472 no 1707 0.464635373415603 2130 4910486 SGTC_2903 5923464 63.88 µM 0.0867374931507357 0.494040435853905 no 1708 0.465440086742451 2251 2876576 SGTC_454 lyso-paf C-16 6.67 µM 0.0863314482058651 0.493952205900012 no 1709 0.46560146986928 2155 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_222 nsc-310342 10.666 µM 0.0854280358039013 0.493755903490533 no 1710 0.465960552639353 2258 432556 SGTC_76 0433-0009 400.328 µM 0.0852553784356148 0.493718386955259 no 1711 0.466029182584838 2088 2841569 SGTC_1123 mangostin 811.285 nM 0.0848337443705162 0.493626770773451 no 1712 0.466196783050132 2112 5281650 An antioxidant. SGTC_900 1112-0045 141 µM 0.0841467968665431 0.493477505787235 no 1713 0.466469859016137 2254 56211 YIL048W NEO1 SGTC_1341 1486-1360 280 µM 0.0830265720811006 0.493234097107448 no 1714 0.46691520554399 2233 3976547 SGTC_2487 5918373 44.05 µM 0.0826178959760248 0.493145298309845 no 1715 0.467077685495988 2289 2876279 SGTC_213 1246-0773 967 nM 0.0826019375322042 0.493141830801466 no 1716 0.467084030307219 2189 6251622 SGTC_460 trequinsin 123 µM 0.0819643176444776 0.493003286873431 no 1717 0.467337544171241 2259 5537 A vasodilator. SGTC_493 zm226600 134 µM 0.0817561014201092 0.492958045220655 no 1718 0.467420332574807 2225 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2976 9009005 19.48 µM 0.081710499660357 0.492948136787854 no 1719 0.467438464380329 2260 2993148 SGTC_3260 9137109 49.47 µM 0.0813750912530045 0.492875258776817 no 1720 0.467571828851387 2258 17478346 SGTC_257 daunorubicin 18.5 µM 0.0800151803154887 0.492579777875587 no 1721 0.468112591268449 2251 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.0791187034246394 0.492384993954094 no 1722 0.468469103482413 2254 16486 A toxic proline analog. SGTC_3004 9076122 71.4286 µM 0.0789996529247068 0.492359127139302 no 1723 0.468516449563985 2250 44782551 SGTC_477 mead ethanolamide 10 µM 0.0785520564275988 0.492261875457313 no 1724 0.468694461533291 2270 16061185 SGTC_227 fluconazole 33.516 µM 0.0785135001977637 0.492253498160724 no 1725 0.468709795884044 2145 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2847 9005661 71.43 µM 0.0777822906961384 0.492094625423693 no 1726 0.469000616870916 2277 2991449 SGTC_1448 4255-0083 152 µM 0.0757126233154973 0.491644947610494 no 1727 0.469823866434346 2268 5399660 SGTC_327 1273-0057 3.96 µM 0.075253447295469 0.491545183593623 no 1728 0.470006530039165 2272 3108138 SGTC_1967 st070177 51.4 µM 0.0747716535038087 0.491440506039212 no 1729 0.470198197945549 2240 5729214 SGTC_2457 5731572 11.68 µM 0.0740990667196303 0.491294376584718 no 1730 0.470465778935555 2289 2865357 SGTC_2178 5812956 200 µM 0.0738621175663026 0.491242896144097 no 1731 0.470560049639778 2284 5403383 SGTC_1950 st077106 7.18 µM 0.0735024005164922 0.49116474297988 no 1732 0.470703166954049 2115 13831864 SGTC_533 1222-0222 6.71 µM 0.0729156278258619 0.491037259781207 no 1733 0.470936628920286 2252 3982874 SGTC_2614 arthonioic acid 13.39 µM 0.0705566222121458 0.490524747717709 no 1734 0.471875317393182 2280 6710684 SGTC_2850 9015429 58.44 µM 0.069868727008138 0.490375300116695 no 1735 0.472149072255787 2227 6457570 SGTC_2830 7992007 71.43 µM 0.0685999950322813 0.490099667287221 no 1736 0.47265401141143 2275 1952075 SGTC_1138 3761-0006 1.03 µM 0.0683510825015771 0.490045591432088 no 1737 0.472753080608567 2277 12061087 SGTC_1454 4239-0054 42.6 µM 0.0656166270803707 0.489451547563473 no 1738 0.473841525573072 2275 1340767 SGTC_355 1311-2252 105 µM 0.0655331847720085 0.489433420588876 no 1739 0.473874742742963 2198 5338538 SGTC_3305 9127027 53.8275 µM 0.0648891133052798 0.489293503491319 no 1740 0.474131144325132 2212 41905295 SGTC_2227 7312221 64.1025 µM 0.0624613745823131 0.488766117240868 no 1741 0.475097710234585 2271 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_561 1550-0330 72.9 µM 0.0618816672913632 0.488640188250691 no 1742 0.475328533448365 2249 6812934 SGTC_1207 2099-0101 141 µM 0.0602134400378236 0.488277807979939 no 1743 0.475992820767971 2305 5837381 SGTC_916 4466-0038 42 nM 0.0590698559701988 0.488029398773856 no 1744 0.476448234076938 2307 5722064 YGL116W CDC20 SGTC_1898 st060199 18.6 µM 0.0589378619533467 0.488000727345061 no 1745 0.476500800487488 2301 688866 SGTC_642 0335-0876 158 µM 0.0583471311139829 0.487872410948375 no 1746 0.476736063116931 2262 6812350 SGTC_106 0092-0003 11.579 µM 0.0572778949265798 0.487640158568317 no 1747 0.477161914366121 2307 1072148 SGTC_1391 3442-0225 151 µM 0.055240804679394 0.487197687026194 no 1748 0.477973310557142 2287 5227075 SGTC_1836 st055642 81 µM 0.0545339256141777 0.487044151155893 no 1749 0.478254890031546 2280 8571 SGTC_2502 avocadyne acetate 18.59 µM 0.053240741480455 0.48676327336991 no 1750 0.478770047311356 2309 3952079 SGTC_2837 9008476 45.46 µM 0.0522683720264374 0.486552080401008 no 1751 0.479157427160833 2251 2992805 SGTC_1508 1080-0625 72.9 µM 0.0512477775547389 0.486330417297569 no 1752 0.4795640404264 2310 767111 SGTC_1447 4239-0816 81.9 µM 0.0486332496166023 0.485762586917823 no 1753 0.480605785972246 2238 1341554 SGTC_2103 5378138 10 µM 0.0479235651558196 0.48560846062467 no 1754 0.480888579343307 2323 244142 SGTC_1116 jasmonic acid  1.58368 µM 0.0471922575888401 0.485449640565413 no 1755 0.481179999098815 2311 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_331 k048-0133 24.5 µM 0.0458776297201556 0.485164145065562 no 1756 0.481703892148282 2310 6813582 SGTC_105 0111-0055 734.78 µM 0.0440059744938668 0.484757694037456 no 1757 0.482449820762646 2262 5179370 SGTC_923 1900-2434 73.3 µM 0.0432757401856348 0.484599119698179 no 1758 0.482740864814085 2327 5910570 SGTC_425 3825-7017 13.1 µM 0.0430762572396878 0.484555801317402 no 1759 0.482820372852637 2267 3397440 SGTC_2413 inermin 26.06 µM 0.0425475800458791 0.4844409982011 no 1760 0.483031091338185 2303 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_962 1254-0300 21.5 µM 0.0410124775368536 0.484107655527263 no 1761 0.483642974298122 2312 7340576 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.040205499753972 0.483932427283193 no 1762 0.483964646503757 2330 77254 SGTC_2404 5161160 200 µM 0.0400039477632078 0.483888662495095 no 1763 0.484044989477077 2320 2831543 SGTC_3196 9111891 49.47 µM 0.0368583518586878 0.483205656582391 no 1764 0.485298973783706 2352 18891510 SGTC_680 0417-1641 114 µM 0.0364077310533203 0.483107816892534 no 1765 0.485478624889355 2313 2835990 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.0359594746263094 0.483010491570439 no 1766 0.485657336301519 2299 2374 Ca(2+)-ATPase inhibitor. SGTC_2293 7624732 200 µM 0.0356372865346779 0.482940538798429 no 1767 0.485785788419343 2339 894453 SGTC_1369 1866-0067 208 µM 0.0354795646922305 0.482906294769155 no 1768 0.485848670564061 2323 3531355 SGTC_2565 isoliquiritigenin 100 µM 0.0334689216683259 0.482469761940277 no 1769 0.486650324428405 2227 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2346 9031566 143.75 µM 0.0332224699836573 0.482416255990252 no 1770 0.486748589777696 2329 4771086 SGTC_80 0159-0065 512.242 µM 0.0317760757634474 0.482102242653485 no 1771 0.487325312887321 2349 1548079 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.0301015143356464 0.481738707915516 no 1772 0.487993046507203 2340 2724278 An inhibitor of dopamine biosynthesis. SGTC_2364 9055074 200 µM 0.0293503185243808 0.481575633849367 no 1773 0.488292597894584 2332 6470630 SGTC_1224 0823-0416 294 µM 0.025429931491892 0.480724623504018 no 1774 0.489856018472677 2349 3598164 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.02388546082374 0.480389384459274 no 1775 0.490471985778703 2346 17037758 SGTC_3000 9075062 71.4286 µM 0.0232502731477409 0.480251516179556 no 1776 0.49072531862847 2342 17057871 SGTC_1167 k781-0610 148 µM 0.0215714165115545 0.479887129663328 no 1777 0.491394917272035 2339 4525169 SGTC_2234 tolnaftate 200 µM 0.0210998003108033 0.479784770994888 no 1778 0.491583022094594 2365 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2493 resveratrol 26.09 µM 0.0209013783577777 0.479741706275829 no 1779 0.491662163547292 2366 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2856 9022925 19.48 µM 0.0202624139034685 0.479603029557014 no 1780 0.491917019493408 2351 4944862 SGTC_2354 9060492 162 µM 0.0200528256575647 0.479557542414529 no 1781 0.492000616120402 2352 6471895 SGTC_338 4055-0136 114 µM 0.0181489429547602 0.479144353151288 no 1782 0.492760016768864 2371 2900563 SGTC_303 1348-1668 34.2 µM 0.0166420201520535 0.478817329794383 no 1783 0.493361100979544 2360 5380509 SGTC_1516 st013856 110 µM 0.0163771768066603 0.478759856545643 no 1784 0.493466743789051 2355 5281404 A mutagen and neurotoxin. SGTC_633 0437-0093 97.7 µM 0.0153049982354687 0.478527189241682 no 1785 0.493894427467908 2381 2831118 SGTC_652 0437-0092 114 µM 0.0152904167377964 0.47852402504501 no 1786 0.493900243963213 2374 3091274 SGTC_1111 tnp00062 510.699 nM 0.0135205668260191 0.478139976309195 no 1787 0.494606238573689 2373 676306 SGTC_2834 9001755 58.44 µM 0.0128083597575577 0.477985436581822 no 1788 0.4948903434605 2343 2989575 SGTC_1886 st057356 49.9 µM 0.0114883130773953 0.477699012286737 no 1789 0.495416926996511 2386 24207747 SGTC_1377 2944-0135 198 µM 0.00976223074835162 0.477324503603698 no 1790 0.496105495262009 2382 1894137 SGTC_1620 st003704 16.5 µM 0.00868678480303754 0.477091173827291 no 1791 0.496534517845721 2380 2834414 SGTC_154 3389-1638 511.116 µM 0.00671047541640559 0.476662412395674 no 1792 0.497322927726458 2365 5238686 SGTC_3188 9110789 49.47 µM 0.00487130078296275 0.476263426685215 no 1793 0.498056639842977 2392 849217 SGTC_2141 5621638 7.665 µM 0.00469055404917783 0.476224217241659 no 1794 0.498128746532945 2392 2856238 SGTC_985 1493-0307 8.71 µM 0.00409313754116594 0.476094621138141 no 1795 0.49836707893493 2402 3278274 SGTC_3352 9151559 45.5865 µM 0.0032513910106769 0.475912027414337 no 1796 0.498702884941142 2397 17159339 SGTC_3183 9108214 49.47 µM 0.00283826270629923 0.475822412456484 no 1797 0.498867698523824 2399 4974831 SGTC_2007 4011539 71.82 µM 0.000339737677326159 0.475280463676514 no 1798 0.499864464278876 2404 45595301 SGTC_2484 5809818 12.04 µM -0.00118707153009415 0.474949309779005 no 1799 0.499526427088006 2418 2870548 SGTC_1264 0783-0040 158 µM -0.00356615862272736 0.474433337535454 no 1800 0.49857731156228 2410 2855798 SGTC_1873 rapamycin 2 nM -0.00557869098001202 0.473996896486005 no 1801 0.49777443584271 2418 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2708 st078559 56 µM -0.00628069763750973 0.473844665492009 no 1802 0.497494380635253 2419 17250902 SGTC_2236 dapsone 200 µM -0.00682988363005153 0.473725576505837 no 1803 0.497275291833152 2414 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_832 4083-0019 164 µM -0.00792222587515767 0.473488713050894 no 1804 0.496839522203018 2431 1990758 SGTC_3220 9131269 49.47 µM -0.00899590545278431 0.473255905541645 no 1805 0.496411201369164 2423 17722206 SGTC_2817 7995342 71.43 µM -0.0118457060503584 0.472638023631401 no 1806 0.495274357533181 2428 18879975 SGTC_399 oxolinic acid 75 µM -0.0126804734404141 0.472457045239062 no 1807 0.494941358576349 2439 4628 A DNA gyrase inhibitor. SGTC_3101 9120531 49.47 µM -0.0131684068382031 0.472351263428598 no 1808 0.494746717573089 2423 24824904 SGTC_2449 5812982 45.77 µM -0.0132090348934076 0.472342455533112 no 1809 0.494730510733688 2420 776185 SGTC_2663 amphotericin b 100 µM -0.0134641371558956 0.472287151347595 no 1810 0.494628748705962 2439 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2446 5162541 200 µM -0.0139968043904184 0.472171674959698 no 1811 0.494416265257491 2433 1549321 SGTC_1179 1021-1431 9.29 µM -0.014764457559502 0.47200526032721 no 1812 0.494110047624107 2447 2840958 SGTC_1079 idarubicin 2.36 µM -0.0162038520968158 0.471693236365375 no 1813 0.493535881169482 2431 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2780 5215298 71.43 µM -0.0164339525216729 0.471643358077575 no 1814 0.493444096603701 2438 2834131 SGTC_2311 7694451 200 µM -0.0167459725439366 0.471575722996193 no 1815 0.493319635753656 2455 2163142 SGTC_3116 9124943 49.47 µM -0.0178937489620651 0.471326932084508 no 1816 0.492861807911337 2444 41905195 YPL160W CDC60 SGTC_1665 st014639 11.4 µM -0.0193214949448139 0.471017470866564 no 1817 0.492292318321103 2447 981133 YIL048W NEO1 SGTC_2868 9035608 32.47 µM -0.0206081589345309 0.470738603887646 no 1818 0.491779115980289 2433 6462614 SGTC_1175 0741-0056 27.6 µM -0.0219018103051861 0.470458236954484 no 1819 0.491263140353853 2450 765927 SGTC_27 0485-0001 32.618 µM -0.0236994653620819 0.470068664031912 no 1820 0.490546166233158 2445 2054479 SGTC_131 0141-0277 33.849 µM -0.0279561612616331 0.469146303040043 no 1821 0.488848557856535 2475 1547771 SGTC_177 1327-0068 8.361 µM -0.0287163179600038 0.46898160597313 no 1822 0.488545420942305 2454 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_3161 9100388 49.47 µM -0.0308125742003967 0.46852745449933 no 1823 0.487709506210193 2456 25236368 SGTC_2272 7805186 180 µM -0.031471474443881 0.468384712960109 no 1824 0.487446770484073 2457 2956062 YPR165W RHO1 SGTC_714 4296-0578 26.1 µM -0.0327571681432904 0.468106197088307 no 1825 0.48693411736837 2498 1589775 SGTC_360 0957-0399 1.01 µM -0.0327598246907378 0.468105621624718 no 1826 0.486933058127771 2487 6752301 YPR165W RHO1 SGTC_1815 st051655 58.2 µM -0.0331939159451957 0.468011589300559 no 1827 0.486759974911511 2458 5984156 SGTC_136 0097-0015 404.482 µM -0.034470283144657 0.467735114535328 no 1828 0.486251069437602 2455 4861337 SGTC_2645 abamectin 100 µM -0.0356956319381386 0.467469705542323 no 1829 0.485762526771274 2475 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2761 levamisole 97.89 µM -0.035774959313886 0.467452523830589 no 1830 0.485730899927471 2482 26879 An alkaline phosphatase inhibitor. SGTC_2339 9000433 200 µM -0.0362905994471459 0.467340841543451 no 1831 0.485525322779141 2504 2988954 SGTC_3069 9117009 49.47 µM -0.0363441718223809 0.467329238471725 no 1832 0.485503964583469 2464 41904981 SGTC_2432 5630864 12.22 µM -0.0368188229434898 0.467226436496676 no 1833 0.485314732842484 2527 5714970 SGTC_2767 sibutramine 71.45 µM -0.0372035526009828 0.467143111701521 no 1834 0.485161353004515 2493 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_510 ag-490 170 µM -0.0383631391539381 0.466891977032099 no 1835 0.48469907501412 2478 5328779 SGTC_3013 9080133 71.4286 µM -0.0390738968563026 0.466738052900333 no 1836 0.484415736181072 2516 17050193 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.0411989037049637 0.466277883870471 no 1837 0.483568663824503 2580 61125 An anti-inflammatory. SGTC_2373 9071805 200 µM -0.0413806019940276 0.466238539292152 no 1838 0.483496238458104 2480 10149009 SGTC_1610 st001799 48.1 µM -0.0447967673745073 0.465498871622871 no 1839 0.482134650884726 2487 621897 SGTC_3065 9113888 49.47 µM -0.0464501299745785 0.465140928414961 no 1840 0.481475740831002 2553 16648368 SGTC_2597 laccaic acid a 100 µM -0.046752886681057 0.465075386428252 no 1841 0.481355089461052 2520 5491415 A textile dye. SGTC_1929 genistein trimethyl ether 50.5 µM -0.0493468777189226 0.464513867857825 no 1842 0.48032143099032 2494 136420 SGTC_3001 9076041 71.4286 µM -0.0511761687023184 0.464117925543801 no 1843 0.479592570787927 2504 16004211 SGTC_2989 9073649 71.4286 µM -0.0514905095489298 0.464049891360737 no 1844 0.479467332052053 2493 21367202 SGTC_1560 lithocholic acid 53.1 µM -0.0520872580787737 0.463920737324414 no 1845 0.479229582882289 2500 9903 A bile acid which acts as a detergent. SGTC_1247 0448-0043 5.84 µM -0.0534390982902121 0.463628173192373 no 1846 0.478691026885829 2540 3089013 YGL099W LSG1 SGTC_144 4161-2749 112.381 µM -0.0539017861559346 0.463528043180074 no 1847 0.478506706794988 2497 797501 YMR168C CEP3 SGTC_1212 0520-0165 585 µM -0.0552177073050136 0.463243278099213 no 1848 0.477982511033671 2618 5403258 SGTC_1077 5-fluorocytosine 377 nM -0.0557298965735806 0.463132445524846 no 1849 0.47777849124214 2564 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_983 1491-0821 12.2 µM -0.0560455270782831 0.46306414770238 no 1850 0.477652769384854 2551 46495113 SGTC_2173 5763948 167 µM -0.056441984285374 0.462978361707172 no 1851 0.477494855809987 2513 2867177 SGTC_475 α-linolenic acid 10 µM -0.0567837881855619 0.462904403057026 no 1852 0.477358714126493 2626 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_627 1391-0720 175 µM -0.0571162750677064 0.462832461629621 no 1853 0.477226285978866 2550 997839 SGTC_2799 7812892 81.82 µM -0.0575941922427258 0.462729055037213 no 1854 0.477035937957254 2551 20205235 SGTC_2970 9090938 41.86 µM -0.0582823525464453 0.462580162717754 no 1855 0.4767618621229 2516 17217104 SGTC_1300 1094-0077 113 µM -0.0588914479233221 0.462448381483835 no 1856 0.476519284899504 2512 5532636 SGTC_3297 9117502 71.43 µM -0.0627025208401777 0.461623928424224 no 1857 0.475001695002847 2504 7453720 SGTC_492 tmb-8 126 µM -0.0629151600482951 0.461577932804186 no 1858 0.474917031394095 2509 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_3153 9100258 49.47 µM -0.0634747685062737 0.461456887322132 no 1859 0.474694225266788 2557 25236848 SGTC_402 epigallocatechin gallate 10 µM -0.063995379957986 0.461344280249593 no 1860 0.474486952764196 2534 65064 An antioxidant. SGTC_3313 9133968 57.047 µM -0.0682573049974088 0.460422552900217 no 1861 0.47279040524992 2516 1494643 SGTC_1540 guanosine 70.6 µM -0.071480569799378 0.45972559773958 no 1862 0.471507644025145 2511 6802 Guanosine is a purine nucleoside SGTC_2647 atorvastatin 60.16 µM -0.0745415114600308 0.459063855652743 no 1863 0.470289755827498 2604 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_125 0133-0007 11.75 µM -0.0750020958937922 0.458964292110697 no 1864 0.470106522154863 2617 26541 SGTC_1596 piperlongumine 63 µM -0.0754774903033079 0.458861529827713 no 1865 0.469917403288578 2552 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_418 lividomycin a 100 µM -0.076691577222053 0.458599102666422 no 1866 0.469434452605195 2548 72394 An antibiotic. SGTC_2861 9024595 19.48 µM -0.0769759313586953 0.458537641590854 no 1867 0.469321346069095 2514 16482810 SGTC_3087 9117406 49.47 µM -0.0773815458544642 0.458449972687584 no 1868 0.4691600105168 2642 42546093 SGTC_672 1441-0018 53.7 µM -0.0787111177898573 0.458162615214626 no 1869 0.468631201100683 2554 251141 SGTC_1878 temozolomide 1 mM -0.0789252704152038 0.458116332916952 no 1870 0.468546031525233 2522 5394 DNA alkylating agent. SGTC_790 1575-0012 79.1 µM -0.0792849501690801 0.458038600824296 no 1871 0.468402988320564 2531 378741 YLR208W SEC13 SGTC_2097 5376186 200 µM -0.0807912587198594 0.457713082827603 no 1872 0.467803979938079 2568 742755 SGTC_1719 st032227 49.2 µM -0.0820317521589229 0.457445029597115 no 1873 0.46731073198222 2577 3125804 SGTC_128 0906-2981 13.371 µM -0.0821369351539081 0.457422301915968 no 1874 0.467268911166922 2589 6740226 SGTC_2091 4-phenylthiadiazole 200 µM -0.0824311993375673 0.457358718779627 no 1875 0.467151913490252 2586 270010 SGTC_2134 5324836 1.464 µM -0.0828081953711831 0.45727726095311 no 1876 0.467002026273915 2589 699272 SGTC_35 0133-0054 64.071 µM -0.0830662754753803 0.45722149841876 no 1877 0.466899420707005 2580 99677 SGTC_1670 st016595 4.04 µM -0.0834551106135393 0.457137485657365 no 1878 0.466744834682629 2541 597879 SGTC_1587 estradiol valerate 56.1 µM -0.0841762336974428 0.456981682945693 no 1879 0.466458156937019 2564 13791 A steroid. SGTC_2924 9010168 62.78 µM -0.0852058376882755 0.456759242659129 no 1880 0.466048874828746 2645 2993929 SGTC_1802 st050112 57.9 µM -0.0856135760485613 0.456671156767327 no 1881 0.465886802980306 2526 4662563 SGTC_1441 4106-0040 13 µM -0.0866303059680235 0.456451516465199 no 1882 0.465482687885896 2553 2904180 SGTC_375 3970-0961 9.27 µM -0.0881764737992562 0.456117529225565 no 1883 0.464868207829612 2617 2898222 SGTC_1059 3448-6867 171 µM -0.0931805018203387 0.455036824399782 no 1884 0.462880082140214 2541 3934407 SGTC_366 0181-0206 4.31 µM -0.0945088141183613 0.454750008350106 no 1885 0.462352490566061 2604 274874 SGTC_2825 7998094 58.44 µM -0.0956424751992928 0.454505241047688 no 1886 0.461902264739444 2646 2987815 SGTC_1413 3910-0535 34.4 µM -0.0968271367405307 0.454249480760489 no 1887 0.461431836591324 2687 2876951 SGTC_3178 9107506 49.47 µM -0.0999622714253831 0.453572718525018 no 1888 0.460187139205026 2677 8897194 SGTC_2971 9092186 9.93 µM -0.100668077917138 0.453420378939866 no 1889 0.459906976369933 2595 25236400 SGTC_1362 1611-0397 101 µM -0.101145476840188 0.45331734218257 no 1890 0.459717488914029 2598 27816 SGTC_2129 girgensonine 121.053 µM -0.106007836549607 0.452268081858638 no 1891 0.457788067278402 2653 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.107215165029601 0.452007600901065 no 1892 0.457309142411719 2692 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2722 naftopidil 47.16 µM -0.107278619965166 0.451993911077654 no 1893 0.457283972721627 2587 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1407 3909-7909 12.3 µM -0.108228024964521 0.45178909243587 no 1894 0.456907407406355 2598 4411780 SGTC_1089 terbinafine 2.25 µM -0.108427804364801 0.451745994921432 no 1895 0.45682817322759 2703 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_936 3005-4620 401 µM -0.109727629725337 0.451465603332546 no 1896 0.456312693684298 2623 777207 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.109952647437123 0.4514170661328 no 1897 0.456223464500844 2675 5379071 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.1124673053529 0.450874694171771 no 1898 0.455226445893772 2700 23847180 SGTC_2415 st077333 57.7 µM -0.113145252763358 0.450728487285843 no 1899 0.454957699398415 2600 2766255 SGTC_2795 7780010 54.55 µM -0.117035022441974 0.44988974508815 no 1900 0.453416150140874 2723 953673 SGTC_732 3970-1727 52.7 µM -0.117822155345096 0.449720044513844 no 1901 0.453104287196065 2703 1275699 SGTC_3249 9135183 49.47 µM -0.119137901886432 0.449436398930652 no 1902 0.452583051603456 2780 4902779 SGTC_235 0330-0087 5 mM -0.123334510861213 0.448531877024728 no 1903 0.450921106862897 2630 46494818 YHR062C RPP1 SGTC_3331 9141060 1.957 µM -0.124227636326231 0.448339410356519 no 1904 0.450567520548521 2641 4906567 YPR165W RHO1 SGTC_1688 st021091 57.6 µM -0.124997992608289 0.44817340995555 no 1905 0.450262569771279 2605 3656366 SGTC_508 roscovitine 141 µM -0.12500135283201 0.448172685896824 no 1906 0.450261239668039 2628 160355 A CDKinase inhibitor. SGTC_1408 3909-7976 48.8 µM -0.12573098347431 0.448015469674712 no 1907 0.449972437607002 2657 24152374 SGTC_994 3910-0338 138 µM -0.125862181784095 0.447987200753445 no 1908 0.449920509558919 2766 3479481 SGTC_2423 st077119 87.2 µM -0.129590860413851 0.447183904101423 no 1909 0.448445067300609 2572 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_686 1319-0111 510 µM -0.13021189098038 0.447050131876021 no 1910 0.448199393517869 2736 4562600 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.133221222439363 0.446401996611573 no 1911 0.447009213682588 2619 756377 SGTC_3120 9124077 49.47 µM -0.134158864736221 0.446200080917193 no 1912 0.446638476486009 2619 18774327 YGL155W CDC43 SGTC_12 0849-0099 9.267 µM -0.136373571936228 0.445723212369007 no 1913 0.445762982506229 2608 6071388 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.139321070212166 0.445088681861864 no 1914 0.444598220315296 2639 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1624 st003710 6.25 µM -0.139714736239135 0.445003944976706 no 1915 0.444442691388247 2795 24207033 SGTC_1876 myriocin 605 nM -0.14161878174861 0.444594133400465 no 1916 0.443690565385104 2736 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_3335 9143315 29.6265 µM -0.14342613060647 0.444205188817994 no 1917 0.442976823537279 2723 4899691 SGTC_2314 7727897 200 µM -0.144193296104593 0.444040109704699 no 1918 0.442673917279509 2688 900724 SGTC_2920 7982904 15.77 µM -0.148067545879608 0.443206595304157 no 1919 0.44114473085944 2767 6456808 SGTC_1880 MG-132 525 µM -0.149960643168936 0.442799401444351 no 1920 0.440397833131966 2729 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1054 3429-0080 167 µM -0.151200187771215 0.442532815543875 no 1921 0.439908901088997 2793 1162877 SGTC_2465 5809242 33.21 µM -0.151886156134113 0.442385297140385 no 1922 0.439638363705665 2657 2731748 SGTC_2533 agelasine 13.65 µM -0.152617601944267 0.442228007552607 no 1923 0.439349921636705 2781 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_3319 9138450 16.7555 µM -0.153118932477798 0.442120207049234 no 1924 0.439152242986372 2704 2029690 SGTC_1256 0570-0116 285 µM -0.154197159360676 0.44188837174821 no 1925 0.438727140953364 2712 410638 SGTC_3162 9099653 49.47 µM -0.155261443879268 0.44165955378883 no 1926 0.438307605145296 2679 25237511 SGTC_2336 9001819 198.65 µM -0.155866765750136 0.441529420093932 no 1927 0.438069021087681 2868 2989602 SGTC_2985 9022375 71.43 µM -0.157456513340641 0.441187682047606 no 1928 0.437442538823902 2889 4939335 SGTC_3011 9081274 71.4286 µM -0.157655881945296 0.4411448281165 no 1929 0.437363983363008 2713 6625322 SGTC_2327 6189656 200 µM -0.159476351323661 0.440753553360036 no 1930 0.436646794385716 2794 5349088 SGTC_2063 5246145 200 µM -0.160040400662919 0.44063233355885 no 1931 0.436424624617092 2793 711240 SGTC_2750 bromebric acid 70.15 µM -0.160469846198314 0.440540045180585 no 1932 0.436255486518769 2816 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1736 st036774 51 µM -0.163421066493252 0.439905911900844 no 1933 0.435093458591294 2978 1272247 SGTC_2483 5729050 27.16 µM -0.164203878835371 0.439737733597059 no 1934 0.434785323843273 2775 2865180 SGTC_1431 4049-0260 9.09 µM -0.164378438692884 0.439700232884222 no 1935 0.434716618059882 2663 3854841 SGTC_2915 7971052 15.16 µM -0.165140101436062 0.439536611130825 no 1936 0.434416854959234 2680 5741558 SGTC_977 1348-1378 135 µM -0.165153903660484 0.43953364620747 no 1937 0.43441142324669 2683 X977 SGTC_328 k915-0120 63.5 µM -0.166070407551325 0.439336775120873 no 1938 0.434050771049113 2827 6624543 SGTC_34 0469-0683 81.75 µM -0.166515064749097 0.439241265221418 no 1939 0.433875814357823 2782 3690923 SGTC_865 0488-0499 301 µM -0.167524591597946 0.439024437593798 no 1940 0.433478649820073 2691 9634651 SGTC_108 0509-0257 621.132 µM -0.167883524171487 0.438947349945245 no 1941 0.433337455981282 2805 536624 SGTC_2687 chenodiol 100 µM -0.168025566588837 0.438916844253452 no 1942 0.433281582893565 2798 5702181 A cholesterol synthesis inhibitor. SGTC_2362 9071156 126 µM -0.169269206415349 0.438649769880681 no 1943 0.432792448083567 2875 653133 SGTC_705 1124-0212 310 µM -0.169412928301912 0.438618907089485 no 1944 0.432735927586278 2732 9554485 SGTC_2275 7947463 200 µM -0.170208823292821 0.438448003619358 no 1945 0.432422956493615 2674 1225414 SGTC_1471 k673-0312 37 µM -0.172295434538676 0.437999997694994 no 1946 0.431602636696714 2712 24099884 SGTC_2940 9060638 45.86 µM -0.17247315262789 0.437961844391552 no 1947 0.431532783083013 2815 4027022 SGTC_305 1682-2595 20.8 µM -0.17457648489138 0.437510335640293 no 1948 0.430706213573412 2759 226033 SGTC_2998 9066762 71.4286 µM -0.17645045403118 0.437108131305741 no 1949 0.429970034915423 2863 4945196 SGTC_1342 1486-1464 234 µM -0.176780792987973 0.437037238379833 no 1950 0.42984028820192 2729 3253938 SGTC_1588 farnesol 29.9 µM -0.177449760897739 0.436893679635038 no 1951 0.429577561948238 2716 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1046 2001-0062 216 µM -0.178474508595754 0.43667378760881 no 1952 0.429175169489975 2690 739778 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.179041733264513 0.436552080025879 no 1953 0.428952466346966 2744 688669 SGTC_1071 trifluoperazine 6.31 µM -0.181043544623373 0.436122605842219 no 1954 0.428166698523805 2862 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1364 1653-0028 37.6 µM -0.181835606336651 0.43595269548091 no 1955 0.427855870248163 2792 5718652 SGTC_1049 3226-0134 66 µM -0.184833818916823 0.435309636516632 no 1956 0.426679690598768 2689 5702385 SGTC_2876 9059903 25.97 µM -0.186120451003781 0.435033731015887 no 1957 0.426175152268121 2713 6916095 SGTC_185 k048-0037 25.491 µM -0.186214961255359 0.435013465474393 no 1958 0.426138095886887 2777 6827589 SGTC_846 0335-0850 148 µM -0.186265452322282 0.435002638900737 no 1959 0.426118299188268 2734 6819598 SGTC_1433 4060-0023 7.6 µM -0.186534018511048 0.43494505227322 no 1960 0.426013002030199 2850 3840627 SGTC_1578 josamycin 24.2 µM -0.188548043501738 0.434513244104371 no 1961 0.425223528768087 2757 5282165 A P450 substrate. SGTC_2394 5221648 200 µM -0.192838788497629 0.433593566896641 no 1962 0.423542612378467 2872 788586 SGTC_2051 5263410 176 µM -0.19413918086508 0.433314911866566 no 1963 0.4230334516578 2744 227584 SGTC_3261 9137475 49.47 µM -0.198306346994713 0.432422173207738 no 1964 0.421402693059756 2727 17027690 SGTC_1272 0839-0021 27 µM -0.199789841110266 0.432104444899658 no 1965 0.420822473385829 2840 5027250 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.200058477958984 0.432046914118955 no 1966 0.420717423316014 2759 97141 SGTC_234 nsc-17383 10.7 µM -0.200966842633034 0.431852391067656 no 1967 0.420362250423636 2901 408974 SGTC_941 3237-0776 460 µM -0.205421273940011 0.430898730544073 no 1968 0.418621500237898 2943 760008 SGTC_2380 9035439 200 µM -0.207078971071039 0.430543932490742 no 1969 0.417974092399848 2928 6462575 SGTC_300 r073-0011 5.04 µM -0.20862093237883 0.430213955773921 no 1970 0.417372084220378 2805 2735780 SGTC_92 0063-0024 660.874 µM -0.212858386061485 0.429307400578039 no 1971 0.41571871080959 2720 3594437 SGTC_1400 3771-8998 51.5 µM -0.212964108164957 0.429284787277818 no 1972 0.415677479007543 2788 670767 SGTC_2743 auranofin 4.32 µM -0.21375643699252 0.429115320462477 no 1973 0.41536849898253 2817 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_169 k015-0017 16.025 µM -0.214623743439823 0.428929832079016 no 1974 0.415030340350491 2965 1840002 SGTC_802 4112-3352 742 µM -0.214713244025514 0.428910691733877 no 1975 0.414995448079097 2939 704594 SGTC_168 3970-0862 530.542 µM -0.218852063833633 0.428025758633382 no 1976 0.413382644361795 2875 3135186 SGTC_2480 5767542 37.17 µM -0.222080831136289 0.42733565753207 no 1977 0.41212547990899 2846 2867358 SGTC_1229 0139-0193 12.2 µM -0.224094144324638 0.426905454095228 no 1978 0.411342024389103 2917 3090752 SGTC_155 k072-0202 43.6 µM -0.224113417120141 0.426901336316213 no 1979 0.411334526325832 2759 5857737 SGTC_587 k089-0003 57 µM -0.228182021927843 0.426032227057073 no 1980 0.409752368609868 2787 9659696 SGTC_471 1-acyl-paf 4 µM -0.231018716038637 0.425426482897699 no 1981 0.408650130990423 2810 16759367 SGTC_1507 4075-3230 155 µM -0.232281104066647 0.425156970614414 no 1982 0.408159843943283 2775 659771 SGTC_2491 paeonol 100 µM -0.233827229752196 0.424826929700958 no 1983 0.407559554602668 2772 11092 Increases levels of cortical cytochrome oxidase. SGTC_1223 0764-0573 147 µM -0.234783730374859 0.424622778396659 no 1984 0.407188298049484 2816 1609797 SGTC_3286 9117135 37.221 µM -0.23508585608767 0.424558298206671 no 1985 0.40707104815786 2854 3438150 SGTC_153 4077-0274 519.67 µM -0.236310009365526 0.424297057985009 no 1986 0.406596060256771 3112 3121976 SGTC_3272 9137413 49.47 µM -0.238570940032876 0.423814651974691 no 1987 0.405719150503199 2807 17614870 SGTC_3271 9137798 49.47 µM -0.239102493892357 0.42370125293516 no 1988 0.405513054005503 2965 6498326 SGTC_1569 carminic acid 40.6 µM -0.240266924644074 0.423452861201136 no 1989 0.405061667190397 2966 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2936 9038235 15.59 µM -0.241186514054352 0.423256719538764 no 1990 0.404705281325458 2816 4749415 SGTC_116 0155-0182 31.788 µM -0.241561920328725 0.423176653603458 no 1991 0.40455981573852 2853 771486 SGTC_1329 1447-1697 50.6 µM -0.246208769496615 0.422185846161588 no 1992 0.402760313699779 2947 2840515 SGTC_335 4077-0256 27.6 µM -0.248687532985997 0.421657521790083 no 1993 0.401801246586966 2933 3121989 SGTC_1804 st050076 49.1 µM -0.250114480934944 0.421353445569891 no 1994 0.401249408823096 2969 3895976 SGTC_2734 clemastine 41.6 µM -0.250217863988868 0.421331416923735 no 1995 0.401209435553543 2856 26987 Clemastine is a selective histamine H1 antagonist. SGTC_703 3875-0075 71.8 µM -0.253138178060373 0.420709264441834 no 1996 0.400080718778591 2874 2850814 SGTC_588 3970-1144 52.9 µM -0.253467980810231 0.420639014687669 no 1997 0.399953300528197 2985 1888707 SGTC_490 phenamil 164 µM -0.253707986196123 0.420587893842233 no 1998 0.399860581900708 2940 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_671 0560-0003 407 µM -0.25479185896682 0.420357046998149 no 1999 0.399441931705743 2898 3238678 SGTC_2828 7998861 71.43 µM -0.254834460397314 0.420347974162101 no 2000 0.399425479090829 2970 2988188 SGTC_984 1492-0255 2.91 µM -0.261332878206117 0.418964503053121 no 2001 0.396917907057737 2992 1585198 SGTC_1807 st050092 58.9 µM -0.261431419300484 0.418943531957 no 2002 0.396879915087971 2874 5008496 SGTC_1109 tnp00067 928.257 nM -0.261646082641631 0.418897849016168 no 2003 0.396797156221877 2899 676295 SGTC_1783 st039459 87.517 µM -0.263253378485493 0.418555831917679 no 2004 0.396177645578314 3093 729761 SGTC_1074 carmofur 3.8 µM -0.264933795851061 0.418198321089346 no 2005 0.395530231479156 2873 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1140 3229-1848 2.98 µM -0.268088615946458 0.41752731203974 no 2006 0.394315554182058 2990 2849525 SGTC_182 3448-4371 550.524 µM -0.268594976098677 0.417419634944393 no 2007 0.394120689383664 2873 3491403 SGTC_2803 7707263 71.43 µM -0.268728451451444 0.417391252544659 no 2008 0.394069327889795 2901 2199229 SGTC_2247 cerulenin 830 nM -0.269494301111317 0.417228409445442 no 2009 0.393774663554601 3103 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1126 isoteolin 1.0172 µM -0.270114796002576 0.417096483632627 no 2010 0.393535969750526 2871 133323 SGTC_692 k241-0027 77.8 µM -0.274685737052419 0.416124926800171 no 2011 0.39177884499605 3061 3600480 SGTC_2294 7971431 200 µM -0.277311758455603 0.415566995369018 no 2012 0.390770365776086 3031 5741572 SGTC_1790 st045711 43.5 µM -0.282041210521377 0.414562593459482 no 2013 0.388955955509039 3075 585119 SGTC_1777 st045864 34.765 µM -0.282633012062047 0.41443695071511 no 2014 0.388729085847467 2944 4691462 SGTC_2041 5107442 45.335 µM -0.282765605706699 0.414408801550076 no 2015 0.388678260704909 3070 793005 SGTC_1196 1588-0294 184 µM -0.283545208295038 0.41424330355435 no 2016 0.388379465848497 2959 6144269 SGTC_1143 3454-2408 5.08 µM -0.287315126837568 0.413443221447057 no 2017 0.386935520594433 2898 X1143 SGTC_861 0443-0273 110 µM -0.287671468480667 0.413367614321514 no 2018 0.386799116030315 3002 6149169 SGTC_2290 7904846 200 µM -0.288629148393021 0.413164433604829 no 2019 0.386432593595531 2974 2962154 SGTC_3207 9114163 49.47 µM -0.291139111601569 0.412632032002794 no 2020 0.385472464071703 3183 849233 SGTC_2383 9036125 200 µM -0.291927630612425 0.412464808180406 no 2021 0.385170978516236 2924 79580 SGTC_2 0422-0095 29 µM -0.296615433320983 0.411470979428967 no 2022 0.383380063394843 2972 6790840 SGTC_2325 6158266 200 µM -0.29710711240265 0.411366774722939 no 2023 0.38319236725448 3004 3623240 SGTC_2009 4012297 12.05 µM -0.298451862578211 0.411081805136316 no 2024 0.382679155458182 3043 45595307 SGTC_2522 biochanin a 4.94 µM -0.302180636371538 0.410291876611195 no 2025 0.381257182303349 3065 5280373 A possible chelator. SGTC_1206 3978-0017 132 µM -0.302341545640267 0.410257796675444 no 2026 0.38119585523973 3201 3873677 SGTC_2624 nerol 100 µM -0.303037288622833 0.410110448914417 no 2027 0.380930722310205 2911 637566 A natural product oil. SGTC_2601 securinine 100 µM -0.303475382445903 0.410017673829015 no 2028 0.38076380269468 2915 442872 A GABA receptor antagonist. SGTC_3312 9133330 71.43 µM -0.30469483582338 0.4097594568466 no 2029 0.380299291564391 3083 17617324 SGTC_2932 9016711 44.54 µM -0.306870706590608 0.409298817539877 no 2030 0.379470893367799 3083 7117328 SGTC_772 k072-0172 35.3 µM -0.306913426169172 0.409289774909722 no 2031 0.379454634679572 2954 5861980 SGTC_2270 7924575 90.91 µM -0.307469622861168 0.409172046858734 no 2032 0.379242970675061 3106 1262135 SGTC_2709 st078560 56 µM -0.30879496458383 0.408891549823408 no 2033 0.378738749881601 3118 17250903 SGTC_3028 9087778 49.47 µM -0.309434131495454 0.408756292378312 no 2034 0.378495655157789 2935 17217395 SGTC_1150 3909-7983 10.9 µM -0.309703306291011 0.408699334146079 no 2035 0.378393294131819 2985 23965914 SGTC_1684 st024538 14.6195 µM -0.31328645073621 0.407941313659422 no 2036 0.377031521569691 2960 6732859 SGTC_828 2074-0507 139 µM -0.314107616336331 0.407767643050091 no 2037 0.376719652540471 3106 X828 SGTC_724 3910-0327 137 µM -0.314377744229772 0.407710516906091 no 2038 0.37661707871793 3028 2885483 SGTC_1343 1487-0095 224 µM -0.316792614830383 0.407199911885264 no 2039 0.375700484165918 3096 4560101 YGL055W OLE1 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.31990843972292 0.406541328758612 no 2040 0.374518869925036 2894 4000243 SGTC_708 3448-5400 146 µM -0.320833122334268 0.406345931967884 no 2041 0.374168428605934 3074 3462195 SGTC_1296 1068-0102 11.9 µM -0.324317225805882 0.405609907979478 no 2042 0.372848939791492 3066 767053 SGTC_1625 st003711 30.1 µM -0.325446077214764 0.405371507236773 no 2043 0.372421743623304 3181 24207034 YER133W GLC7 SGTC_2185 6113692 200 µM -0.330454714899844 0.404314163764946 no 2044 0.370528202357004 3120 874150 SGTC_2342 7990637 118.86 µM -0.330558351372549 0.404292293040627 no 2045 0.370489054976806 3100 2033102 YER133W GLC7 SGTC_274 sirtinol 40.1 µM -0.331248187007068 0.404146722524813 no 2046 0.370228512392116 3018 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_394 menadione 8.33 µM -0.331895775537334 0.404010079155597 no 2047 0.369983980198282 3126 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_392 N-ethylmaleimide 8.33 µM -0.331950372295357 0.403998559590172 no 2048 0.369963366630127 3030 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_47 0149-0135 24.25 µM -0.332636112783044 0.403853879842751 no 2049 0.369704490079862 2981 5239155 SGTC_1849 st056239 19.2 µM -0.333333243196661 0.403706810494407 no 2050 0.369441374197833 2985 5393181 SGTC_2111 5486399 200 µM -0.335240879925227 0.403304437670502 no 2051 0.368721693346001 2993 689674 SGTC_2929 9013348 24.6 µM -0.338697622213955 0.402575577100227 no 2052 0.367418766051735 3089 2995952 SGTC_2534 helenine 20.12 µM -0.339082408132101 0.402494465162064 no 2053 0.36727382525466 2952 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1947 st076332 61.6 µM -0.340222704098786 0.402254118201912 no 2054 0.366844410770076 3115 24208416 SGTC_1799 st045822 46.1415 µM -0.340270602365033 0.402244023207595 no 2055 0.366826376805826 3147 3674992 SGTC_2070 5230947 200 µM -0.340632379968668 0.402167777400787 no 2056 0.366690175017812 3104 2835538 SGTC_1591 genipin 88.4 µM -0.340867053909284 0.402118321094695 no 2057 0.36660183410457 3124 442424 A DNA cross-linking agent. SGTC_3171 9103192 49.47 µM -0.340965966063291 0.402097476344753 no 2058 0.366564601622433 3097 13018434 SGTC_1422 4031-0024 15.5 µM -0.343256488140423 0.40161484966157 no 2059 0.365702755898779 3069 782427 SGTC_3025 9087895 49.47 µM -0.345062620661127 0.401234392503663 no 2060 0.365023646958561 3139 17173641 SGTC_2058 5236698 133 µM -0.345164975037785 0.401212834618128 no 2061 0.364985174186475 3033 766665 SGTC_1018 4259-0013 28.1 µM -0.347031966404157 0.400819661610635 no 2062 0.364283651820268 3148 6801262 SGTC_1685 st024049 53.0905 µM -0.348663623945519 0.400476130204739 no 2063 0.363670928182516 3083 1941139 SGTC_1773 st048542 73.5835 µM -0.349054334568203 0.400393880869682 no 2064 0.363524259327596 2991 3237138 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.349218687760325 0.400359283844654 no 2065 0.363462568760446 3022 5106787 A p450 inhibitor. SGTC_1078 idebenone 36.1 µM -0.350092263784913 0.400175405615381 no 2066 0.363134728288763 3093 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1312 1218-2183 165 µM -0.350362208709594 0.400118589625098 no 2067 0.363033442120344 3053 6744073 SGTC_83 0170-0301 39.027 µM -0.352681244700424 0.399630583470326 no 2068 0.36216371077514 3003 3089716 SGTC_2556 citropten 84.59 µM -0.352816322373373 0.399602163234804 no 2069 0.362113073114435 3046 2775 A potential DNA crosslinker. SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.353341283739804 0.399491716830811 no 2070 0.361916299518565 3043 4330530 SGTC_1334 1486-0610 236 µM -0.354276378481303 0.399295002564516 no 2071 0.361565884246631 3109 3742339 SGTC_254 nsc-64875 3.808 µM -0.35586619141401 0.398960615073431 no 2072 0.360970387930874 3176 56993 SGTC_989 1501-0895 10.3 µM -0.357869530707921 0.398539355626241 no 2073 0.360220476805561 3155 2830112 SGTC_857 0438-0306 1.35 µM -0.35796790017919 0.398518673668696 no 2074 0.360183667927505 3122 4686136 SGTC_1025 k007-0731 70 µM -0.358664064735538 0.398372314803738 no 2075 0.35992320713494 3015 6256118 SGTC_797 k781-0471 270 µM -0.361143508959675 0.397851162575101 no 2076 0.358996084743175 3033 23738129 SGTC_2763 lisinopril 49.32 µM -0.361819809864999 0.3977090430664 no 2077 0.358743343791335 3075 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2610 ononetin 44.17 µM -0.362083353007173 0.397653665147368 no 2078 0.358644871611248 3087 259632 SGTC_1183 1254-0324 198 µM -0.364333344311777 0.397180961976995 no 2079 0.357804551619387 3174 5799357 SGTC_2140 5586273 200 µM -0.365513752702401 0.396933029010639 no 2080 0.357363971386328 3100 854421 SGTC_3105 9121040 49.47 µM -0.366046475377693 0.396821149580337 no 2081 0.357165198104017 3096 41448907 SGTC_1396 3511-0007 98.6 µM -0.367037400437277 0.396613063650443 no 2082 0.356795560215874 3144 X1396 SGTC_93 0109-0045 59.227 µM -0.367458749115092 0.396524592888409 no 2083 0.356638428157109 3106 88733 SGTC_1732 st034308 51.822 µM -0.371753178846551 0.395623194237048 no 2084 0.355038313494703 2950 830119 SGTC_1152 3909-8331 15.9 µM -0.372067355404235 0.395557270582677 no 2085 0.354921350458691 3082 16001939 SGTC_1738 st035555 74 µM -0.373828623999524 0.395187759046628 no 2086 0.354265911042465 3166 5331140 SGTC_3258 9138477 49.47 µM -0.376935839906124 0.394536099709628 no 2087 0.353110643068055 3104 4970355 SGTC_1008 4106-0037 6 µM -0.379319756336091 0.394036333898617 no 2088 0.352225215265412 2994 2905394 SGTC_2638 epoxomicin 18 µM -0.381542245140418 0.393570566975807 no 2089 0.351400465234522 3185 9915668 A protesome inhibitor. SGTC_949 1165-0505 146 µM -0.38381295557725 0.393094851479546 no 2090 0.350558542505066 3080 6244267 SGTC_1080 nisoldipine 24.4 µM -0.384182187999715 0.393017512084414 no 2091 0.350421709572505 3001 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.385812591848657 0.392676058346648 no 2092 0.349817734515622 3266 551469 SGTC_1796 st049173 110.4 µM -0.386740848680089 0.392481691386383 no 2093 0.349474035941085 3189 94134 SGTC_446 go6976 132 µM -0.387160379203892 0.392393855018862 no 2094 0.349318740036727 3197 3501 A protein kinase C inhibitor. SGTC_1389 3405-0187 19 µM -0.39147729817066 0.391490348454645 no 2095 0.347722232945993 3132 799890 SGTC_2676 harmalol 100 µM -0.395224763412455 0.390706499498197 no 2096 0.346338509338909 3184 5459187 A monoamine oxidase inhibitor SGTC_863 0466-0191 129 µM -0.402556510475797 0.389174220787061 no 2097 0.343637254162792 3217 765160 YPR165W RHO1 SGTC_2954 9074818 52.69 µM -0.403531051981506 0.388970678245162 no 2098 0.343278797990803 3256 16648742 SGTC_2836 9010338 19.48 µM -0.40373815450015 0.388927426778729 no 2099 0.343202639623796 3103 2994051 SGTC_2012 4023501 200 µM -0.405465452366073 0.388566750085864 no 2100 0.342567704013679 3174 3477460 SGTC_2285 7945142 200 µM -0.407255820578822 0.388193005062433 no 2101 0.341910053632199 3223 2970608 SGTC_484 loperamide 105 µM -0.407397834276069 0.388163363681088 no 2102 0.341857908678776 3135 3955 An opioid-receptor agonist. SGTC_2435 5706476 10.6 µM -0.409506911181831 0.387723229723627 no 2103 0.34108384798418 3271 5725375 SGTC_3192 9110362 49.47 µM -0.410515457723563 0.387512811532972 no 2104 0.340713933316318 3186 16649480 SGTC_2490 carminic acid 95.39 µM -0.410619942244045 0.387491014284042 no 2105 0.340675619235295 3217 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3340 9146634 11.102 µM -0.412622668574082 0.387073280114888 no 2106 0.339941545137091 3217 4907387 SGTC_3006 9075424 71.4286 µM -0.41313353658157 0.386966742772413 no 2107 0.339754389875463 3142 7465181 SGTC_199 4063-0024 41.6 µM -0.414027141558747 0.386780409246295 no 2108 0.339427114838724 3238 306215 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.414318553873123 0.386719649911805 no 2109 0.339320413784108 3114 688803 SGTC_1701 st028638 40.4 µM -0.414742920394323 0.386631174651932 no 2110 0.339165054388669 3252 3490878 SGTC_1278 0874-0585 172 µM -0.414844312925001 0.386610036414042 no 2111 0.339127938912846 3194 766306 SGTC_1052 3253-3998 198 µM -0.415801066506563 0.386410589726488 no 2112 0.338777789192755 3079 5450317 SGTC_1118 chelidonine 707.474 nM -0.416576525104478 0.386248958152467 no 2113 0.338494091422351 3237 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2146 5545642 200 µM -0.417095427386279 0.386140812538662 no 2114 0.33830430470038 3223 825326 SGTC_1626 st003712 1.76 µM -0.417213225286375 0.386116263240055 no 2115 0.338261226242914 3266 24207035 SGTC_3240 9133527 49.47 µM -0.417359134144738 0.386085856198326 no 2116 0.338207870599284 3154 17617455 SGTC_1951 sophoraflavanone G 9.2 µM -0.419020845572444 0.385739609092451 no 2117 0.337600448904851 3133 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2453 5731132 22.18 µM -0.420247464481041 0.3854840796203 no 2118 0.337152342008607 3281 1362040 SGTC_1664 st014217 9.02 µM -0.426062097052362 0.38427345227277 no 2119 0.335031299061978 3270 3982782 SGTC_1128 3448-9350 235 µM -0.426996803758483 0.384078947923386 no 2120 0.334690827859508 3204 619386 SGTC_1007 4101-0031 70 µM -0.43101521536811 0.383243084451236 no 2121 0.333228653606612 3278 1146276 SGTC_277 nystatin 15.5 µM -0.431689167724779 0.383102949773504 no 2122 0.332983670681231 3107 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3131 9127911 49.47 µM -0.433011156508861 0.382828113553996 no 2123 0.332503332397922 3376 45595681 SGTC_3301 9125354 19.7965 µM -0.435011884137551 0.382412282451516 no 2124 0.331776900644851 3190 41905162 SGTC_130 0136-0219 337.655 µM -0.436315592848555 0.382141392630331 no 2125 0.331303885077782 3164 234244 SGTC_499 genistein 192 µM -0.436442523550783 0.382115021539594 no 2126 0.331257846052578 3248 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_518 1021-0119 62.6 µM -0.437088356502045 0.381980851920908 no 2127 0.331023635546662 3173 1097762 SGTC_2168 5727979 200 µM -0.441704105238445 0.381022359200369 no 2128 0.329351669309865 3224 695210 SGTC_2149 5554786 194.827 µM -0.442479432126942 0.380861428519531 no 2129 0.329071155316003 3193 745063 YPR165W RHO1 SGTC_2667 digitoxin 100 µM -0.448602217961948 0.379591278892447 no 2130 0.326859316758361 3258 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3326 9140064 16.379 µM -0.449233334997969 0.379460429535477 no 2131 0.326631671350211 3152 1868434 SGTC_2269 7935389 174.42 µM -0.450298522242227 0.379239615816726 no 2132 0.326247602200901 3247 97605 SGTC_2623 humulene 100 µM -0.451315934695405 0.379028742610844 no 2133 0.325880930930264 3264 6187145 An anti-inflammatory. SGTC_1992 st073643 23.3 µM -0.452611612319267 0.378760247107553 no 2134 0.325414217754742 3177 3161292 SGTC_2977 9011197 71.43 µM -0.453303681340176 0.378616857755995 no 2135 0.325165041168237 3359 2704722 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.454954190631186 0.378274957234484 no 2136 0.324571097778152 3284 616764 SGTC_531 3788-1495 174 µM -0.463921914538654 0.376418978420583 no 2137 0.321351845695622 3154 2896655 SGTC_969 1313-0238 134 µM -0.466062405801513 0.375976398128548 no 2138 0.320585415897597 3200 5212874 SGTC_1288 0973-0013 65.5 µM -0.468936834196844 0.37538232140088 no 2139 0.319557393364766 3339 4315430 SGTC_483 fpl-64176 144 µM -0.470620815229365 0.375034419270563 no 2140 0.318955770225946 3321 3423 SGTC_447 ml7 120 µM -0.470891173307588 0.374978574094874 no 2141 0.31885922581135 3324 4216 Selective myosin light chain kinase inhibitor. SGTC_2788 5282734 71.43 µM -0.471950461786399 0.374759792686653 no 2142 0.318481074143767 3357 743706 SGTC_2440 5628896 157.78 µM -0.472414317824662 0.374664002311212 no 2143 0.318315543291342 3217 5522048 SGTC_1483 3453-0561 55.9 µM -0.472464974381954 0.374653541752287 no 2144 0.318297468277348 3315 4546991 SGTC_195 4234-0266 16.654 µM -0.473228769074963 0.374495829636452 no 2145 0.318024987412064 3241 2303354 SGTC_3266 9136860 49.47 µM -0.474548449780937 0.374223384907941 no 2146 0.31755442843527 3303 4871271 YPR165W RHO1 SGTC_3146 9095609 49.47 µM -0.479279376264975 0.373247214155617 no 2147 0.315869945988374 3273 17173999 SGTC_1989 st071868 50.2 µM -0.481345862805035 0.372821073830582 no 2148 0.315135353179474 3352 16414057 SGTC_2303 7774051 200 µM -0.48232169439347 0.372619896863376 no 2149 0.3147887191477 3391 2953184 SGTC_273 hydroxyurea 18.1 mM -0.484256449500701 0.372221131469016 no 2150 0.314101939687807 3244 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1915 st067105 30.6 µM -0.487013102922244 0.371653204288782 no 2151 0.313124522713498 3333 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_693 4161-2696 114 µM -0.491146811458588 0.370802099111119 no 2152 0.311661307409067 3339 805759 SGTC_1204 4049-0315 18.3 µM -0.492524796592864 0.37051852063764 no 2153 0.311174198446072 3439 588402 SGTC_1293 1000-1278 195 µM -0.492877435814012 0.370445961564555 no 2154 0.311049595809576 3392 678847 SGTC_1415 3966-0071 78.1 µM -0.495251906063862 0.369957510498845 no 2155 0.310211157523157 3337 2893185 SGTC_594 1487-1584 10.8 µM -0.499491871737508 0.369085831300531 no 2156 0.308716455788302 3264 5013332 SGTC_2930 9013230 14.89 µM -0.50054468171521 0.36886949200655 no 2157 0.308345801299573 3378 2995857 SGTC_2386 9075165 157.42 µM -0.500817506649362 0.368813436666616 no 2158 0.308249781827204 3344 16452277 SGTC_980 1473-0395 201 µM -0.502452560323815 0.368477552686967 no 2159 0.307674607345489 3271 768876 SGTC_3082 9117008 49.47 µM -0.503249712036541 0.36831383271252 no 2160 0.307394358811782 3317 41448529 SGTC_2862 9027634 71.43 µM -0.503762086353902 0.368208613281495 no 2161 0.307214286624692 3233 5012562 SGTC_2813 7971799 71.43 µM -0.504490088489159 0.368059130263424 no 2162 0.306958512718438 3357 2234054 SGTC_2771 fluoxetine 41.05 µM -0.505762427517672 0.367797924778189 no 2163 0.306511718830024 3429 3386 A selective serotonin reuptake inhibitor. SGTC_3241 9133421 49.47 µM -0.506303804834721 0.367686800979508 no 2164 0.306321696198218 3348 17018221 SGTC_611 3453-1652 23.7 µM -0.507382718406417 0.367465374842453 no 2165 0.305943154495203 3408 1560575 SGTC_1698 5-fluorocytosine 1.055 µM -0.508346472359871 0.367267620240561 no 2166 0.305605192232149 3396 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_175 3793-3120 23.7 µM -0.512584169057377 0.366398497113955 no 2167 0.30412111471061 3278 5322297 SGTC_1606 st000094 49.2 µM -0.513754462700356 0.366158598227237 no 2168 0.303711834503435 3427 1242210 SGTC_1151 3909-8316 15.3 µM -0.513901121514509 0.366128538273987 no 2169 0.303660561679543 3399 800431 SGTC_3206 9114350 49.47 µM -0.514582406488211 0.365988909338508 no 2170 0.303422430942335 3352 17087243 SGTC_749 1000-0129 128 µM -0.515993997583857 0.365699661110521 no 2171 0.302929300748502 3444 708470 SGTC_754 3474-0146 171 µM -0.522760903071328 0.364314121587912 no 2172 0.300570325056441 3252 24762078 SGTC_301 4119-0100 24.5 µM -0.523188681712503 0.364226592261224 no 2173 0.300421478491066 3346 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_795 0685-0265 78 µM -0.529270351254608 0.362982967907231 no 2174 0.298308959955466 3466 302754 SGTC_665 3914-0008 307 µM -0.536113509919432 0.361585354834779 no 2175 0.295940051833501 3336 1069549 SGTC_2644 guaiazulene 100 µM -0.54090274302308 0.360608321411562 no 2176 0.294287310072681 3420 3515 A coloring agent. SGTC_1926 methyl fluorone black 53.6 µM -0.541104686768502 0.360567143562485 no 2177 0.294217714000857 3320 72721 Reacts with homocysteine. SGTC_1502 4534-4282 27.7 µM -0.54270534841385 0.360240813842685 no 2178 0.293666345584229 3371 3278949 SGTC_1856 st057054 55.7 µM -0.546688340565618 0.359429236457113 no 2179 0.292296432892053 3525 1266018 SGTC_2873 9040596 71.43 µM -0.547768707584734 0.359209209189826 no 2180 0.291925363903294 3448 6463863 SGTC_2202 7226349 200 µM -0.548360257241902 0.35908875411487 no 2181 0.291722279890551 3340 844334 SGTC_3129 9127257 49.47 µM -0.548799165451058 0.358999389906415 no 2182 0.291571641543449 3311 837894 SGTC_3133 9127736 49.47 µM -0.550623077343334 0.358628113768902 no 2183 0.290946042865253 3473 27243420 SGTC_1512 0259-0544 12.2 µM -0.55073227135549 0.358605890431981 no 2184 0.290908609413221 3430 18476 SGTC_906 1165-0455 526 µM -0.553204203665304 0.35810292711236 no 2185 0.290061794409204 3431 3252859 SGTC_1787 fluconazole 80 µM -0.557261314397854 0.357277961911419 no 2186 0.288674451471631 3411 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1368 1852-0141 284 µM -0.564512475804352 0.355805187040217 no 2187 0.286202706022371 3440 2838987 SGTC_3180 9109287 49.47 µM -0.56532255379452 0.355640786141838 no 2188 0.285927195429878 3470 18891271 SGTC_2393 9031399 185.94 µM -0.567391820461194 0.355220961740884 no 2189 0.285224002937398 3524 1526623 YDL150W RPC53 SGTC_1093 fluphenazine 7.97 µM -0.568146106759692 0.355067971575677 no 2190 0.284967881254625 3453 6602611 An atypical antipsychotic. SGTC_1430 4049-0248 69.1 µM -0.568538778911684 0.354988336026201 no 2191 0.284834590890006 3497 22774488 SGTC_20 0481-0013 4.944 µM -0.568762520736361 0.354942963084143 no 2192 0.284758656285462 3451 182045 SGTC_946 3434-1334 87.4 µM -0.568872089903257 0.354920744137891 no 2193 0.284721473685309 3442 4047976 SGTC_2661 dactinomycin 12.96 µM -0.569108026374345 0.35487290151607 no 2194 0.284641415859148 3446 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1944 st076371 56.9 µM -0.57050194568154 0.354590292683867 no 2195 0.284168651417654 3357 24208455 SGTC_289 k017-0060 526 µM -0.572211138751468 0.354243873205269 no 2196 0.283589471084774 3407 5512909 SGTC_2884 9058502 51.95 µM -0.576554093192641 0.353364185622081 no 2197 0.282120359125738 3491 6471554 SGTC_968 1309-0633 340 µM -0.577958615159533 0.353079859816228 no 2198 0.281646030089781 3483 3761976 SGTC_1523 st012844 44.7 µM -0.580414796419023 0.352582837488268 no 2199 0.280817464691979 3484 4274103 SGTC_2017 5132927 60.65 µM -0.583660574232516 0.351926421740357 no 2200 0.27972434877187 3417 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1333 1482-0047 286 µM -0.584221241772071 0.351813078747244 no 2201 0.279535736002334 3508 3811116 SGTC_1170 0310-0127 64.8 µM -0.587998850231087 0.351049751620832 no 2202 0.278266532284434 3437 774975 SGTC_2349 9023730 187.07 µM -0.588125459593108 0.351024178529471 no 2203 0.278224042682997 3513 4126287 SGTC_720 r052-1644 49.9 µM -0.590201344762082 0.350604978812004 no 2204 0.277527835340752 3492 1422863 YOR257W CDC31 SGTC_1895 st058434 18.3 µM -0.591615546944965 0.350319502019699 no 2205 0.277054030343149 3545 5393175 SGTC_1298 1079-1278 263 µM -0.592064804698398 0.350228830649203 no 2206 0.27690359688489 3508 2840950 SGTC_1493 4348-0038 111 µM -0.592663696049964 0.350107972777733 no 2207 0.276703121002301 3540 800424 SGTC_1317 1273-0028 910 nM -0.592808455618433 0.350078762188488 no 2208 0.276654674136054 3450 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_859 0439-0102 54.6 µM -0.594622171947341 0.349712853165638 no 2209 0.2760480279808 3548 610143 SGTC_26 0302-0163 425.158 µM -0.598892183204009 0.348851949368549 no 2210 0.27462239219941 3477 3100915 SGTC_1309 pyrazolanthrone 13.4 µM -0.599303186701067 0.348769125325952 no 2211 0.274485361611909 3524 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_632 0781-2353 4.65 µM -0.600372235917726 0.348553727881485 no 2212 0.274129093437478 3536 6811515 YHR007C ERG11 SGTC_2681 menadione 3.18 µM -0.60077832829509 0.348471919125555 no 2213 0.273993820189507 3547 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1037 k284-1091 78.7 µM -0.601301964279598 0.348366441194401 no 2214 0.273819440754212 3520 3334711 SGTC_1246 0422-0085 105 µM -0.602654697283521 0.348094009474751 no 2215 0.273369212477751 3545 264295 SGTC_1792 st045773 43.6 µM -0.604036802496089 0.347815743328413 no 2216 0.272909587219586 3494 2919270 SGTC_608 k048-0125 159 µM -0.605087007219341 0.347604355151341 no 2217 0.272560593373901 3557 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1253 0550-0034 176 µM -0.607130118227533 0.347193247774847 no 2218 0.271882281962681 3513 5969915 SGTC_681 1642-0006 26.6 µM -0.608540284496216 0.346909604050778 no 2219 0.27141459813019 3539 4446530 SGTC_2569 tetrandrine 100 µM -0.610037047028444 0.346608636004975 no 2220 0.270918633401978 3447 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_48 0382-0018 55 µM -0.610534226915949 0.346508684799941 no 2221 0.270753988822255 3661 762596 SGTC_1637 st007924 17.4 µM -0.612279833371512 0.346157839197934 no 2222 0.2701763149802 3547 683336 SGTC_2840 9008771 71.43 µM -0.612761917995872 0.346060969317704 no 2223 0.270016887329766 3478 2992978 SGTC_115 0527-0192 112.043 µM -0.614124960406933 0.345787134671901 no 2224 0.269566377660989 3542 4233931 SGTC_2943 9068529 45.32 µM -0.615901943817921 0.345430260579218 no 2225 0.268979619288107 3572 3270634 SGTC_346 4513-0042 7.16 µM -0.616727838949245 0.345264441628466 no 2226 0.268707127839514 3557 2827372 SGTC_2654 protoveratrine a 100 µM -0.617127345574585 0.34518424141133 no 2227 0.268575366535227 3520 5702278 A heart drug and vasodilator. SGTC_1609 st001574 46.4 µM -0.617884519201449 0.345032259281806 no 2228 0.268325732183868 3475 3960012 SGTC_326 k292-0812 17.5 µM -0.618299957093246 0.344948881977442 no 2229 0.268188815091175 3522 3579357 SGTC_1811 st050069 61.5 µM -0.620018641117105 0.344604026597377 no 2230 0.267622757147682 3535 3877702 SGTC_552 k242-0005 476 µM -0.622182325349465 0.344170065149262 no 2231 0.266910993320734 3585 4088318 SGTC_3174 9107204 49.47 µM -0.622259488720306 0.344154592587015 no 2232 0.266885627391331 3584 3938802 SGTC_2399 5884133 200 µM -0.622984094499277 0.34400930959164 no 2233 0.266647487028523 3541 722445 SGTC_3009 9080819 71.4286 µM -0.623021631371188 0.344001784099935 no 2234 0.266635153531648 3525 17027216 SGTC_2179 6298986 200 µM -0.62821580054156 0.342961040300671 no 2235 0.264931290445253 3542 738374 SGTC_2053 5265679 138 µM -0.62990326193923 0.342623183312403 no 2236 0.264378939289797 3536 764595 SGTC_1310 1188-0297 994 nM -0.631230486717296 0.342357539913052 no 2237 0.263944915416922 3540 1588352 SGTC_2057 5236571 38.335 µM -0.633151019685313 0.341973284238816 no 2238 0.263317513836769 3570 54684039 YBR257W POP4 SGTC_902 1120-0002 2.07 µM -0.6333910865115 0.341925263735245 no 2239 0.263239142153522 3579 3280475 SGTC_3226 9131256 49.47 µM -0.633976742673044 0.341808125818344 no 2240 0.263048000141778 3494 17178073 SGTC_2200 6600604 21.907 µM -0.636328134045607 0.341337974118144 no 2241 0.262281285624806 3547 2904777 SGTC_817 1391-0715 46 µM -0.636473753746536 0.341308866103136 no 2242 0.262233841304435 3505 1353946 SGTC_2019 4016004 108 µM -0.63662904396306 0.34127782608282 no 2243 0.262183251080467 3536 45595336 SGTC_1376 2910-0861 41.3 µM -0.637998876445605 0.341004065105093 no 2244 0.261737205736802 3582 1112859 SGTC_121 0557-0495 61.343 µM -0.639859695967364 0.340632314460107 no 2245 0.261131909286937 3683 3104427 SGTC_1744 st037937 38.9 µM -0.640877982493798 0.340428948789258 no 2246 0.260800980921334 3611 1016152 SGTC_2142 5622915 118.518 µM -0.643515451026606 0.339902426261705 no 2247 0.259944846128505 3558 5322196 SGTC_700 3453-2283 142 µM -0.644493899798106 0.339707176120804 no 2248 0.259627606040118 3650 565664 SGTC_911 3456-4043 236 µM -0.647790370084828 0.339049679912056 no 2249 0.25856027235049 3639 914281 SGTC_759 3486-0358 89.3 µM -0.647818280826008 0.339044115074809 no 2250 0.258551245099881 3629 875103 SGTC_2736 butenafine 14.65 µM -0.648246708721367 0.338958699625604 no 2251 0.25841269792827 3582 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2252 omeprazole 400 µM -0.648740591853361 0.338860244671871 no 2252 0.258253031252148 3543 4594 A proton pump inhibitor. SGTC_1612 st002233 45.4 µM -0.651427741808666 0.338324757873879 no 2253 0.25738520372293 3620 1035021 SGTC_830 4076-0286 57.8 µM -0.654995492916463 0.337614292777796 no 2254 0.256235327953796 3648 6866659 SGTC_3218 9131285 49.47 µM -0.661812343406403 0.336258427271853 no 2255 0.254045747240493 3639 17156417 SGTC_597 k018-0003 82.8 µM -0.662607222901937 0.336100464590457 no 2256 0.253791071513062 3681 6786234 SGTC_1801 st050089 28.441 µM -0.662984364400268 0.336025527146621 no 2257 0.253670284016411 3642 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2589 lobaric acid 100 µM -0.667079369870655 0.335212275865403 no 2258 0.252360718470162 3605 73157 A novel microtubule depolymerizer. SGTC_2899 9053889 58.44 µM -0.667311010326096 0.335166296049793 no 2259 0.252286747467298 3590 6470052 SGTC_2474 5321570 43.32 µM -0.667438804716258 0.335140930369931 no 2260 0.252245943085267 3627 2841384 SGTC_954 1189-0853 2.85 µM -0.668404523048254 0.334949270979478 no 2261 0.251937704540057 3614 2828194 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.668775488669142 0.334875659439116 no 2262 0.25181935238347 3668 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1486 3970-0793 4.53 µM -0.671365834798143 0.334361828187327 no 2263 0.250993752087521 3655 2844330 SGTC_3058 9093861 49.47 µM -0.671738532748625 0.334287923857928 no 2264 0.250875083028388 3645 17217477 SGTC_2069 5228469 200 µM -0.67200431303745 0.33423522474381 no 2265 0.250790475280388 3596 2835210 SGTC_341 1486-1430 230 µM -0.674490759476595 0.333742368671046 no 2266 0.249999679274407 3610 2054753 YPL210C SRP72 SGTC_2161 5662504 8.5105 µM -0.675573634671129 0.333527813921762 no 2267 0.249655692845235 3610 2859334 SGTC_1761 st044296 37 µM -0.677784770230107 0.333089881195634 no 2268 0.24895408440218 3653 1826700 SGTC_2220 6782180 200 µM -0.67806487059277 0.333034421347307 no 2269 0.248865281581759 3573 833803 SGTC_1141 3253-0389 52.6 µM -0.67825445230295 0.332996886256726 no 2270 0.248805186300559 3622 5402031 SGTC_3090 9117696 49.47 µM -0.683691997331347 0.331921025715076 no 2271 0.247084838952239 3617 7923821 SGTC_2759 disulfiram 3.38 µM -0.684465509925968 0.331768092509799 no 2272 0.246840630655699 3619 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2738 aclarubicin 5.55 µM -0.687679339244196 0.33113297830477 no 2273 0.245827366746946 3564 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2505 galangin 7.89 µM -0.689467201960407 0.330779872453492 no 2274 0.245264653034924 3590 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1611 st001856 99.4 µM -0.689686922840617 0.330736487594933 no 2275 0.245195545676281 3632 647478 SGTC_371 0195-0006 7.36 µM -0.690460926935098 0.33058367518238 no 2276 0.244952186703767 3560 3928593 SGTC_1467 k284-1082 293 µM -0.69234531036106 0.330211757553101 no 2277 0.244360250890941 3648 3334705 SGTC_2419 paclitaxel 166.5 µM -0.692451053113582 0.330190892247385 no 2278 0.244327057090426 3623 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_982 1491-0518 27.5 µM -0.695050567911193 0.329678118602314 no 2279 0.243511805865247 3637 3091256 SGTC_150 3970-0969 77.2 µM -0.695786586987822 0.329532991447315 no 2280 0.243281245205456 3729 6615640 SGTC_3338 9144300 39.5675 µM -0.696782718158638 0.32933661665728 no 2281 0.242969391484958 3669 4901274 SGTC_659 k018-0002 107 µM -0.69778698604089 0.329138685460415 no 2282 0.242655209482901 3652 6797879 YHR007C ERG11 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.698230407291906 0.329051306784883 no 2283 0.242516556592896 3724 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2378 9074213 121.43 µM -0.698667422933568 0.328965199509195 no 2284 0.242379948661697 3653 657714 SGTC_2005 4024620 188 µM -0.700867336530714 0.328531877957197 no 2285 0.241692905212143 3678 236743 SGTC_3316 9136639 10.545 µM -0.701062593120854 0.32849342898981 no 2286 0.241631976771856 3692 4903665 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.705396676055991 0.32764045086023 no 2287 0.240281705991256 3713 279621 SGTC_3295 9122362 53.5725 µM -0.708276244112123 0.327074228123919 no 2288 0.239386863259044 3693 4730473 SGTC_1892 st058411 7.36 µM -0.709990136815589 0.326737406260499 no 2289 0.238855126282463 3660 3934738 SGTC_1221 2958-7315 257 µM -0.711282303493245 0.326483557191504 no 2290 0.238454657748252 3699 4562705 SGTC_2470 5664817 21.68 µM -0.7159512955232 0.325566993383013 no 2291 0.23701071157773 3721 2859561 SGTC_1687 st020778 55.3625 µM -0.716478421139213 0.325463580128963 no 2292 0.236847993603922 3705 4259299 SGTC_3052 9092717 49.47 µM -0.716676870049608 0.32542465124331 no 2293 0.236786750491457 3689 25237534 SGTC_237 nikkomycin 200 µM -0.716906434355649 0.325379620957641 no 2294 0.236715915754153 3724 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2944 9067346 25.62 µM -0.717904960641847 0.325183784268024 no 2295 0.236407944497081 3643 6473075 SGTC_1501 4491-0275 38.4 µM -0.719436434380365 0.324883516689728 no 2296 0.235936027360358 3696 5104718 SGTC_618 k072-0232 33.2 µM -0.720459981913205 0.324682898783449 no 2297 0.235620915218915 3700 5872756 YGL099W LSG1 SGTC_899 1083-0020 478 µM -0.72058117642025 0.324659147719266 no 2298 0.235583619323981 3737 767123 SGTC_1515 3460-0031 42.1 µM -0.725194559133498 0.323755572038574 no 2299 0.234166340128761 3670 2876596 SGTC_1760 st045453 10.4495 µM -0.728023820979395 0.323201946723518 no 2300 0.233299502242763 3752 3323419 YIL048W NEO1 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.728380295336394 0.323132220141555 no 2301 0.233190410996584 3743 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1273 0849-0096 14.1 µM -0.729239863866377 0.322964113620962 no 2302 0.232927475184907 3744 5286025 SGTC_354 2783-3500 4.88 µM -0.730212145807908 0.322774007229708 no 2303 0.232630259747887 3715 6740761 SGTC_2961 9083290 32.55 µM -0.730948003875182 0.322630158633557 no 2304 0.232405456606929 3699 17741490 SGTC_873 0591-4978 488 µM -0.731733991556177 0.322476539808336 no 2305 0.232165472488816 3753 3305145 SGTC_2703 st077852 53.4 µM -0.736489280642926 0.321547780558981 no 2306 0.230716494350554 3709 6281836 SGTC_995 3931-2021 34.6 µM -0.737160664561891 0.32141674167923 no 2307 0.230512325557052 3741 730143 SGTC_2191 5911152 200 µM -0.740385261047356 0.3207876836648 no 2308 0.229533129754307 3750 2875902 SGTC_2251 lansoprazole 556 µM -0.741877224530657 0.320496803585702 no 2309 0.229080863090098 3676 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1232 0279-0259 161 µM -0.744100099149738 0.320063626181843 no 2310 0.228407959672254 3769 1560000 SGTC_1169 aniline yellow 25.8 µM -0.746219801074569 0.319650782654841 no 2311 0.227767324292848 3690 6051 A DNA damaging agent. SGTC_780 0109-0199 192 µM -0.746237152410011 0.319647404144843 no 2312 0.227762084392549 3767 610414 SGTC_524 r073-0010 27.8 µM -0.747411795763853 0.319418722020825 no 2313 0.227407513645119 3697 2772106 SGTC_3068 9116768 49.47 µM -0.747630689257472 0.319376114946926 no 2314 0.227341474165256 3704 41904888 SGTC_1465 k213-0056 144 µM -0.74990949026768 0.318932693738431 no 2315 0.226654609170323 3652 24048857 YMR208W ERG12 SGTC_2229 7354935 190 µM -0.750138880842376 0.318888072041084 no 2316 0.226585532334793 3678 318112 SGTC_1716 st033144 30.6155 µM -0.750258559096275 0.318864792933793 no 2317 0.226549498104391 3749 674617 SGTC_445 e6 berbamine 66 µM -0.750681627141454 0.318782505964306 no 2318 0.226422141404179 3836 6610268 A calcium/calmodulin antagonist. SGTC_1443 4112-3303 14 µM -0.751037495407528 0.31871329630664 no 2319 0.226315045252222 3763 704433 SGTC_2211 7117706 200 µM -0.753269003792327 0.318279454279005 no 2320 0.225644140510139 3684 822771 SGTC_3086 9117350 49.47 µM -0.75427343965216 0.318084256656428 no 2321 0.225342523736326 3681 2679265 SGTC_1065 prochlorperazine maleate 2.48 µM -0.756677496605615 0.317617268096927 no 2322 0.22462154996499 3807 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_770 0389-1121 67.2 µM -0.756684498175177 0.317615908463839 no 2323 0.224619452115541 3869 6753108 SGTC_1959 st077091 55.8 µM -0.761560599012958 0.316669617895296 no 2324 0.223161149135914 3779 821356 YKL052C ASK1 SGTC_532 1548-0774 215 µM -0.761947875430289 0.316594511594849 no 2325 0.223045557291933 3869 5932993 SGTC_822 1487-0950 154 µM -0.762691209243713 0.316450374629472 no 2326 0.222823787219258 3760 1958375 SGTC_1852 st056254 31.4 µM -0.768370403309286 0.315350065580872 no 2327 0.221133579325209 3725 442583 SGTC_104 0074-0074 590.992 µM -0.768868059422817 0.315253725563917 no 2328 0.220985820260721 3630 3943124 SGTC_653 0203-0016 55.2 µM -0.769034557809723 0.315221496356836 no 2329 0.220936397847515 3819 295302 SGTC_2628 lathosterol 100 µM -0.76955716922493 0.315120343241828 no 2330 0.220781310018492 3836 6710616 SGTC_2100 5377183 190 µM -0.770135801818033 0.315008363218243 no 2331 0.220609670341641 3809 2844202 SGTC_996 3970-0799 1.8 µM -0.772097769294053 0.314628799551479 no 2332 0.220028261662318 3839 6615648 YGL040C HEM2 SGTC_868 0527-0199 213 µM -0.772482686083543 0.314554356230427 no 2333 0.219914298809121 3754 2849450 SGTC_265 mycophenolic acid 32.932 µM -0.77339033890154 0.314378845050202 no 2334 0.21964570292158 3862 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_45 0kpi-0036 14.9 µM -0.774467777971628 0.314170557067169 no 2335 0.219327107946158 3773 2795021 SGTC_3033 9090887 49.47 µM -0.775241354251495 0.31402104760996 no 2336 0.219098528019142 3834 19325384 SGTC_1086 cerivastatin 2.18 µM -0.775271998067879 0.314015125693242 no 2337 0.21908947606282 3739 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1870 st057514 26.5 µM -0.775488712979267 0.313973246909364 no 2338 0.219025466221925 3795 5393161 SGTC_1963 st076565 50.3 µM -0.775745176940347 0.313923689968706 no 2339 0.21894972982913 3809 4914280 SGTC_1563 conessine 56.1 µM -0.77609847361243 0.313855427384761 no 2340 0.218845422434202 3853 441082 An anti-amoebic, histamine inhibitor. SGTC_345 1362-0200 395 µM -0.776665925812402 0.31374579985203 no 2341 0.218677947562866 3796 1419823 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.777654356004615 0.313554881780845 no 2342 0.218386403682174 3796 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3250 9135583 49.47 µM -0.78367487412928 0.312393081619375 no 2343 0.216615454650174 3839 7699353 SGTC_2882 9058044 58.44 µM -0.78557512971911 0.312026768886726 no 2344 0.216058219742001 3780 18076804 SGTC_3099 9120367 49.47 µM -0.787602690677332 0.31163612035604 no 2345 0.215464570171925 3839 24824940 SGTC_3048 9093155 49.47 µM -0.78777313891751 0.311603289881139 no 2346 0.215414707781747 3734 25236002 SGTC_679 0422-0091 41.4 µM -0.789078248056745 0.311351959096137 no 2347 0.215033137197718 3807 627384 YHR062C RPP1 SGTC_66 0109-0187 42.4 µM -0.790875343701116 0.311006028105419 no 2348 0.2145083688845 3792 759417 SGTC_3309 9129340 25.759 µM -0.794587861545757 0.310291917766305 no 2349 0.213426640771177 3864 17158987 SGTC_2426 5582046 32.21 µM -0.794787144332495 0.310253605505346 no 2350 0.213368665172625 3810 2251934 SGTC_1200 1643-0193 18.4 µM -0.795984135212831 0.310023526478448 no 2351 0.213020628319606 3803 5403974 SGTC_31 0508-1974 57.237 µM -0.797582985628544 0.3097163202327 no 2352 0.212556263929913 3768 6810525 SGTC_2321 7390090 138.78 µM -0.798274135032272 0.309583562552645 no 2353 0.212355712147449 3845 649046 SGTC_907 3448-6986 75.5 µM -0.798376967366967 0.309563812386997 no 2354 0.212325882598814 3842 590582 SGTC_2519 cryptotanshinone 88.04 µM -0.801061221144587 0.3090484643842 no 2355 0.211548102302071 3786 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_3074 9116018 49.47 µM -0.801409225275247 0.308981678797031 no 2356 0.211447388094995 3873 17027303 SGTC_363 0455-0021 3.06 µM -0.802223017510774 0.308825528310559 no 2357 0.211211982019157 3834 4597466 SGTC_2139 5578692 56.4705 µM -0.802640519674988 0.308745431386755 no 2358 0.21109127058923 3761 650991 YMR113W FOL3 SGTC_1228 0124-0032 52.5 µM -0.803022702715304 0.308672118338503 no 2359 0.210980806351995 3911 X1228 SGTC_1874 staurosporine 7.6 µM -0.807530876702897 0.307807904695249 no 2360 0.209680346406891 3900 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1154 4088-0362 150 µM -0.808184422740281 0.307682708685088 no 2361 0.209492211847641 3841 6618304 SGTC_1981 st071826 47 µM -0.808421978147233 0.307637207126671 no 2362 0.209423852020967 3869 11838600 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.809644341976405 0.307403121349778 no 2363 0.209072307646577 3864 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2564 betulinic acid 100 µM -0.811075364999162 0.307129176459622 no 2364 0.208661196026453 3850 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_3279 9140807 49.47 µM -0.812458291692142 0.306864541030772 no 2365 0.208264354877402 3890 45595718 SGTC_2999 9069765 71.4286 µM -0.813189745544287 0.306724611446235 no 2366 0.208054638895438 3869 2097066 SGTC_722 3534-0461 190 µM -0.813626428121804 0.306641086022918 no 2367 0.207929496572868 3894 658262 SGTC_560 2332-1943 155 µM -0.814315364983247 0.306509331678062 no 2368 0.207732154866003 3820 21177716 SGTC_209 4077-0173 175.592 µM -0.815644501660764 0.306255214275551 no 2369 0.207351744647809 3812 15993494 SGTC_2060 5238662 140 µM -0.819622052030062 0.305495304135207 no 2370 0.206215799191551 3852 790130 SGTC_3029 9088683 49.47 µM -0.81992793458077 0.305436899966485 no 2371 0.206128595457407 3858 25236615 SGTC_1696 st025591 34.7925 µM -0.821259989928433 0.305182619618338 no 2372 0.205749096207714 3856 2787147 SGTC_2287 7945887 168.79 µM -0.82147909072924 0.305140803758301 no 2373 0.20568671466718 3887 1245853 SGTC_740 k014-0057 261 µM -0.821788037690172 0.305081844887048 no 2374 0.205598771548814 3869 4012779 SGTC_1289 0976-0073 69.1 µM -0.823188290305753 0.304814686685561 no 2375 0.20520046338388 3927 3391136 SGTC_3219 9131112 49.47 µM -0.828963450217904 0.303713927986319 no 2376 0.203562544766335 3831 17612988 YMR079W SEC14 SGTC_398 bronopol 33.3 µM -0.831934995602037 0.303148236765526 no 2377 0.20272281861823 3782 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2045 5106652 78.05 µM -0.834825815271989 0.302598365904204 no 2378 0.201907894278651 3857 673349 SGTC_15 0266-0086 27.098 µM -0.838036273877312 0.301988220050689 no 2379 0.201005165668976 3957 1712902 YIL048W NEO1 SGTC_2888 9058547 12.99 µM -0.838204861596882 0.301956195325385 no 2380 0.200957828555464 3804 16476514 SGTC_2242 6630449 61.2675 µM -0.839189559157285 0.301769173819831 no 2381 0.200681472663638 3967 691249 YDR170C SEC7 SGTC_2612 dictamnine 15.46 µM -0.840225092849676 0.301572553309529 no 2382 0.200391095839067 3884 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_3341 9147222 25.867 µM -0.841813650902865 0.301271040145817 no 2383 0.199946134836767 3905 1939759 SGTC_1351 1496-0003 46.5 µM -0.842650892174589 0.3011121838509 no 2384 0.199711859718137 3935 3891978 SGTC_463 ikarugamyin 104 µM -0.846496891917351 0.300382937876319 no 2385 0.198637803498424 3938 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_707 0865-0008 204 µM -0.847180355706432 0.300253428797079 no 2386 0.198447300618913 3897 723043 SGTC_1375 2910-0797 186 µM -0.84862163909386 0.299980403781519 no 2387 0.198045931046959 3922 742508 SGTC_643 k048-0106 28.4 µM -0.849469752704256 0.299819796550697 no 2388 0.19780997707241 3930 6763920 SGTC_757 1066-0008 322 µM -0.854114477439957 0.298940916573122 no 2389 0.196520781512858 3948 6842497 SGTC_1134 3477-0009 42.5 µM -0.854561677969596 0.298856358585225 no 2390 0.196396925241023 4011 3973534 SGTC_1739 st037196 92.5 µM -0.854991914543657 0.298775018450169 no 2391 0.196277811956788 3964 612214 SGTC_3150 9097574 49.47 µM -0.860669586922318 0.297702546771191 no 2392 0.194710024017731 3926 17217476 SGTC_3057 9095946 49.47 µM -0.861978023653765 0.297455641690876 no 2393 0.194349805634205 3929 24540043 SGTC_1575 cyproterone acetate 48 µM -0.862656627883403 0.297327624318964 no 2394 0.194163142800349 3948 9880 An androgen receptor antagonist and liver toxin. SGTC_1846 st056244 14.8 µM -0.864075957249091 0.297059952002527 no 2395 0.193773082817604 3951 5393182 SGTC_1027 k015-0025 8.67 µM -0.868397646190538 0.296245601115617 no 2396 0.192588341493668 3913 3598955 SGTC_1987 st072290 61.9 µM -0.869403378380482 0.296056234468194 no 2397 0.192313267945778 3952 54697379 SGTC_1851 st056236 18.9 µM -0.871281722155087 0.295702714955057 no 2398 0.191800173952922 3890 5393171 SGTC_2561 acetosyringone 100 µM -0.873317001601292 0.295319878007637 no 2399 0.191245158062008 3940 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1490 4089-0339 670 nM -0.873686838132739 0.295250336091366 no 2400 0.191144410322438 3865 742542 SGTC_2226 7298446 200 µM -0.875102518656979 0.294984209411255 no 2401 0.190759063390416 3908 3283010 SGTC_513 4245-1575 41.7 µM -0.875405211314165 0.294927322081426 no 2402 0.190676732633099 3857 719745 SGTC_3270 9137563 49.47 µM -0.876988494763669 0.294629846012413 no 2403 0.19024644363042 3926 17015724 SGTC_921 1561-0023 372 µM -0.879146353730222 0.294224638534503 no 2404 0.189660963637506 3911 24050882 SGTC_1914 st062367 72.6 µM -0.881453400550033 0.293791701216523 no 2405 0.18903623271523 3942 978205 SGTC_380 3970-0968 6 µM -0.881611808856461 0.293761985342585 no 2406 0.188993383491986 3846 2891601 SGTC_342 k048-0088 23.3 µM -0.88369771417198 0.293370819376152 no 2407 0.188429707301199 3945 6820570 SGTC_640 3381-0960 37.1 µM -0.888590884996894 0.292454160537584 no 2408 0.187111495771017 3987 1745025 SGTC_440 fluspirilene 35.1 µM -0.889136265335701 0.292352074603514 no 2409 0.186964925400611 4056 3396 An atypical antipsychotic. SGTC_2147 5545932 89.7195 µM -0.889647624951263 0.292256371825993 no 2410 0.186827562608984 3980 797404 SGTC_898 1000-0849 28.3 µM -0.890029756465003 0.292184864064704 no 2411 0.186724954204549 3944 6751807 SGTC_1766 st045414 44.774 µM -0.890305951840654 0.292133185060738 no 2412 0.186650813065586 3992 253960 SGTC_2023 5144124 124 µM -0.892953651037933 0.291637989209788 no 2413 0.185940997002838 3958 2830192 SGTC_2087 5276107 200 µM -0.893585259931634 0.291519918025766 no 2414 0.185771917900448 3925 144405 SGTC_1943 st076331 65.2 µM -0.893631580527899 0.291511259861712 no 2415 0.185759521822001 3987 24208415 SGTC_1404 3909-7820 48.3 µM -0.896769933696096 0.290924923960061 no 2416 0.184920847329732 3911 23741373 SGTC_2583 asiatic acid 100 µM -0.897591433008099 0.290771534994145 no 2417 0.184701704003812 3969 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2622 2-methoxyxanthone 59.94 µM -0.897830447724706 0.290726913672102 no 2418 0.184637974722901 3983 71034 A hepatoprotective. SGTC_1891 st059073 26.2 µM -0.900691023578249 0.290193125454023 no 2419 0.183876311344725 4056 688754 SGTC_2099 5377090 177.372 µM -0.901393035850924 0.290062198998588 no 2420 0.183689691435089 4002 2243829 SGTC_1063 disulfiram 1.84 µM -0.901431867042705 0.290054957724983 no 2421 0.183679372164291 3956 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2731 amoxapine 43.43 µM -0.901466844378861 0.290048435194186 no 2422 0.183670077353084 4050 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2982 9019404 25.97 µM -0.904165163838041 0.289545463253094 no 2423 0.182953914580068 3930 22333232 SGTC_3107 9121808 49.47 µM -0.905488051932891 0.289299024071077 no 2424 0.18260344341519 3860 662681 SGTC_2076 5212012 200 µM -0.909712621230438 0.288512695057789 no 2425 0.181487043145283 3904 604802 SGTC_824 1304-0008 100 µM -0.91026143060343 0.28841061784164 no 2426 0.181342326967981 4012 768245 SGTC_2892 9047358 58.44 µM -0.910830392179295 0.288304810341625 no 2427 0.181192373139179 3976 6466771 SGTC_2859 9028643 45.46 µM -0.913789306564179 0.287754848255683 no 2428 0.180413783215758 3877 17151580 SGTC_818 4072-2707 53.5 µM -0.914109493861182 0.28769536600013 no 2429 0.180329657201814 3903 882871 SGTC_1534 6-azauridine 81.6 µM -0.914156165334533 0.28768669617102 no 2430 0.180317396794159 4014 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2541 muurolladie-3-one 83.07 µM -0.914238743159458 0.287671356575732 no 2431 0.180295705214412 4020 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_765 1319-0117 244 µM -0.915983803409319 0.287347285910234 no 2432 0.179837694999987 3947 3487746 YGL099W LSG1 SGTC_2000 st075254 36.4 µM -0.916864445615005 0.287183809704102 no 2433 0.179606838502582 3911 17234175 SGTC_422 cantharidin 155 µM -0.917129512328794 0.287134613210621 no 2434 0.179537388904567 3926 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2348 9022543 33.42 µM -0.917614235603927 0.287044658688223 no 2435 0.179410431193277 4042 3162678 YDL140C RPO21 SGTC_1924 st058459 75.1 µM -0.91792918021033 0.286986218696896 no 2436 0.179327971815385 3952 688683 SGTC_2692 st077426 47.7 µM -0.919686717139658 0.286660199972732 no 2437 0.178868247930342 4013 25238571 SGTC_400 oxethazaine 37.5 µM -0.919887929690515 0.286622886752714 no 2438 0.178815663560586 4012 4621 A local anesthetic. SGTC_3205 9113483 49.47 µM -0.920322386660115 0.286542328122268 no 2439 0.178702156888505 4065 17018033 SGTC_423 5-fluorouracil 457 µM -0.920887857250101 0.286437492549083 no 2440 0.178554489428097 3946 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1550 gossypolone 36.6 µM -0.921006157886168 0.286415562473171 no 2441 0.178523606025123 4003 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2835 9006588 71.43 µM -0.923931226841816 0.285873579052527 no 2442 0.177761061802692 4081 2345538 SGTC_2222 6885208 172.143 µM -0.925541411450743 0.285575437626271 no 2443 0.177342176586017 3931 609514 SGTC_2698 st077697 67.5 µM -0.925998392199043 0.285490850139664 no 2444 0.177223407901512 3976 3154499 SGTC_1839 st053978 48 µM -0.926219414438379 0.285449943033951 no 2445 0.177165982545794 4003 3788398 SGTC_1910 st062352 60.4 µM -0.926474821203515 0.285402675468242 no 2446 0.177099638142451 3934 2245730 SGTC_641 4092-0595 30 µM -0.926770543397664 0.285347951471945 no 2447 0.177022841021722 4031 786260 SGTC_1558 st069300 45.6 µM -0.929817698595039 0.284784360451137 no 2448 0.176232740533276 3938 24208000 SGTC_2782 7736369 71.43 µM -0.93179903956246 0.284418183875147 no 2449 0.175720195546776 4041 2950836 YOL077C BRX1 SGTC_1645 Cervolide 78 µM -0.931886097342989 0.28440209966987 no 2450 0.175697696606195 3988 23173 A fragrance. SGTC_1740 st038286 13.222 µM -0.932266941218999 0.284331742647209 no 2451 0.175599293963142 4068 716786 SGTC_231 b-estradiol 524 µM -0.932658528129555 0.28425940963338 no 2452 0.175498151952551 3983 450 A steroid. SGTC_570 0987-0065 62.6 µM -0.933813848404158 0.284046052864628 no 2453 0.175199962376163 3795 3104428 SGTC_70 0141-0289 43.283 µM -0.935051961297433 0.283817491586917 no 2454 0.174880760842271 4014 352408 SGTC_2805 7950783 58.44 µM -0.939136593227206 0.283064074973322 no 2455 0.173830309248274 4038 1178958 YDL195W SEC31 SGTC_1931 st074438 57.1 µM -0.94008884692574 0.28288856839542 no 2456 0.173585994604106 3985 2787313 SGTC_1690 st023502 41.2 µM -0.940648282202995 0.282785485193003 no 2457 0.173442565224178 4024 24207482 SGTC_3210 9128157 49.47 µM -0.941306092743887 0.282664298161358 no 2458 0.173274010682122 4072 17590849 SGTC_988 1497-1057 103 µM -0.943042547125217 0.282344514833807 no 2459 0.17282957034134 3942 3533044 SGTC_610 4215-0184 155 µM -0.944614836762921 0.282055114112147 no 2460 0.172427774798394 4050 5605015 SGTC_81 0411-0046 9.971 µM -0.945359772279427 0.281918048758281 no 2461 0.172237616167917 3960 12925265 SGTC_2857 9024691 58.44 µM -0.948687269331771 0.281306193832623 no 2462 0.171389845373926 4132 16478292 SGTC_8 0354-0001 70 µM -0.949655051424549 0.281128359993024 no 2463 0.171143777977345 4024 4993152 SGTC_1055 3448-0672 86 µM -0.952337337745707 0.280635763135593 no 2464 0.170462963820271 4074 748378 SGTC_256 clotrimazole 625 nM -0.952995386771084 0.280514977485621 no 2465 0.170296204045659 3958 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2344 7990960 76.95 µM -0.953383861967467 0.280443684232778 no 2466 0.170197807513671 4016 140813 SGTC_1013 4112-3890 241 µM -0.954208740774033 0.280292330962817 no 2467 0.169988995530215 3981 705171 SGTC_1663 st014140 55.4 µM -0.956645671875326 0.279845420761303 no 2468 0.169373064093549 4111 4207120 SGTC_3049 9092223 49.47 µM -0.956715830617598 0.279832559429326 no 2469 0.169355352793474 4022 8623917 SGTC_1812 st052057 4.327 µM -0.959225076917712 0.279372759033906 no 2470 0.168722685008408 4061 3645418 SGTC_2946 9065502 71.43 µM -0.961588727185925 0.278939973977927 no 2471 0.168128118152687 3849 16489101 SGTC_2591 skatole 100 µM -0.962688947483821 0.278738634620225 no 2472 0.167851822471356 4094 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_509 pifithrin 175 µM -0.966463121066017 0.27804850220636 no 2473 0.166906246077981 4092 4817 A p53 inhibitor. SGTC_664 1222-0054 14.9 µM -0.966503194550959 0.278041178981596 no 2474 0.166896224590741 4017 6813991 SGTC_1277 0873-0036 22 µM -0.970904690972214 0.277237401286316 no 2475 0.165797870990491 4121 5965735 SGTC_96 0929-0093 37.281 µM -0.972746135763122 0.276901464057279 no 2476 0.165339744696649 4050 6991579 SGTC_1522 st012842 45.6 µM -0.974796635957585 0.276527623286709 no 2477 0.164830573071155 3908 3491067 YOR116C RPO31 SGTC_3091 9116372 49.47 µM -0.975046173393646 0.276482145297616 no 2478 0.164768678371884 4139 17169793 SGTC_1035 k081-0041 55.2 µM -0.975280769028128 0.276439393784201 no 2479 0.164710503535506 4093 731709 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.976171419019076 0.276277115789895 no 2480 0.164489762046685 4106 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1692 fluoroquinolonic acid 71 µM -0.976862575366504 0.276151218105846 no 2481 0.164318595882734 4107 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2745 rifampicin 24.3 µM -0.976937218273846 0.276137623201343 no 2482 0.164300117338832 4069 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_626 0214-0009 33 µM -0.9773946276533 0.276054321231604 no 2483 0.164186910833321 4133 3437874 SGTC_464 bw-b 70c 158 µM -0.979008177736166 0.275760565093513 no 2484 0.163787969440515 4113 5353454 SGTC_746 1095-0025 46.6 µM -0.981629288242516 0.275283704462959 no 2485 0.163141256569505 4082 6749286 SGTC_2832 7992762 51.95 µM -0.98377023068853 0.274894502570631 no 2486 0.162614249766165 4021 2985177 SGTC_1412 3909-8563 178 µM -0.984236153735174 0.274809838370813 no 2487 0.162499706707571 4144 23767530 SGTC_3296 9122258 64.045 µM -0.984252445193934 0.27480687823618 no 2488 0.162495702546795 4072 4730474 SGTC_1115 galangin 695.678 nM -0.98453288232862 0.274755925676155 no 2489 0.16242678598045 4126 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2537 larixol 68.93 µM -0.984780283506756 0.274710979279064 no 2490 0.162366003694587 4070 6708759 SGTC_114 0364-0001 490.298 µM -0.986620685342469 0.274376739698627 no 2491 0.161914312857967 4136 4003655 SGTC_2516 gossypol 71.55 µM -0.987194118842185 0.274272638164071 no 2492 0.161773742190873 4120 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1323 1348-1351 11.2 µM -0.98997787262372 0.273767550800842 no 2493 0.161092467287316 4021 6989654 SGTC_539 4859-0462 2.54 µM -0.990320853750467 0.273705351771781 no 2494 0.161008658404037 4128 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2101 5377231 179.231 µM -0.99047844035903 0.273676776059144 no 2495 0.160970160995084 4127 2844213 SGTC_1045 1348-1485 165 µM -0.992601277812155 0.273291978683363 no 2496 0.160452150909858 4069 6810614 SGTC_184 1494-0393 24.714 µM -0.992947979161751 0.273229159126718 no 2497 0.160367653195869 4056 3090647 SGTC_4 0960-0234 25.671 µM -0.993333455821062 0.273159322188583 no 2498 0.160273739346217 4087 6821112 SGTC_2756 carbadox 75.1 µM -0.993881761282257 0.273060000741817 no 2499 0.160140217384795 4055 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2711 st079103 59.1 µM -0.995122115693355 0.272835385856445 no 2500 0.159838437815935 4038 54693780 SGTC_1446 4239-0190 62 µM -0.995620612773474 0.272745139205018 no 2501 0.159717257806378 4093 1340085 SGTC_1189 1431-2119 7.28 µM -0.998168084507401 0.272284182731119 no 2502 0.159098929866748 4081 3107275 SGTC_236 1509-0011 5.31 µM -0.998561158383157 0.272213091817692 no 2503 0.159003661951651 4138 3107280 SGTC_1581 himbacine 57.9 µM -0.998896495260043 0.272152450447677 no 2504 0.158922417099488 4080 5281825 An alkaloid muscarinic receptor antagonist. SGTC_550 4123-0385 25.7 µM -0.999077059296923 0.272119800540837 no 2505 0.15887868161975 4117 5731123 SGTC_2302 7771753 200 µM -1.00097894267214 0.271776016962543 no 2506 0.158418494407549 4093 2203047 SGTC_2368 9071271 200 µM -1.00212558300044 0.271568855267265 no 2507 0.158141471696743 4106 27209959 SGTC_311 1315-0136 58 µM -1.0025834445777 0.271486156114842 no 2508 0.158030943453135 4129 6759207 SGTC_1657 st012939 43.4 µM -1.00535463012203 0.270985891290915 no 2509 0.157363059084758 4119 24207257 SGTC_1808 st050063 61.5 µM -1.00539329960351 0.270978913785687 no 2510 0.157353752485382 4077 4011993 SGTC_715 0868-0130 184 µM -1.00840592892072 0.270435591861863 no 2511 0.156629813902015 4148 2876258 SGTC_774 k060-0086 136 µM -1.01009466370728 0.270131270075507 no 2512 0.156224969310329 4082 5911235 SGTC_3159 9100096 49.47 µM -1.01012309353679 0.270126148288508 no 2513 0.156218159662382 4042 25236875 SGTC_2400 5203494 178.7 µM -1.01111787950644 0.269946962828481 no 2514 0.155980006932052 4015 6777674 SGTC_744 1594-0068 283 µM -1.01243180247189 0.269710384146805 no 2515 0.155665819452802 4072 668392 SGTC_3227 9130768 49.47 µM -1.01250611728151 0.269697006481288 no 2516 0.155648061649833 4156 17720899 SGTC_2246 7293507 91.5585 µM -1.01427226278749 0.26937917436948 no 2517 0.155226427744002 4148 887656 SGTC_2843 9000894 45.46 µM -1.01438184341913 0.269359460641063 no 2518 0.155200292299452 4021 2242070 SGTC_2144 5628481 200 µM -1.01445084134955 0.269347048175728 no 2519 0.155183837491368 4077 2818399 SGTC_2207 7258803 200 µM -1.0150198298822 0.269244700237899 no 2520 0.155048187517436 4068 3666799 SGTC_2679 rapamycin 1 nM -1.01692072581926 0.268902914325882 no 2521 0.154595571433767 4039 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1583 clindamycin 39.6 µM -1.01740226314183 0.268816367289304 no 2522 0.154481052925342 4082 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_160 3453-0671 289.699 µM -1.01764369966335 0.268772979002326 no 2523 0.154423655953548 4154 5322268 SGTC_250 brefeldin a 552.239 µM -1.01934289512069 0.268467718019956 no 2524 0.154020103155026 3971 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_529 4076-0302 30.3 µM -1.02056418119179 0.268248421323937 no 2525 0.153730483479536 4063 5816522 SGTC_3031 9088762 49.47 µM -1.02077290764493 0.268210950982509 no 2526 0.153681021519691 4084 205253 SGTC_805 3852-0218 479 µM -1.0237399267592 0.267678599959189 no 2527 0.152979065708794 4075 6615355 SGTC_3211 9128781 49.47 µM -1.02561206510943 0.267342969794759 no 2528 0.152537239070044 4132 17194361 SGTC_1623 st003709 20.3 µM -1.02628430757969 0.267222504432436 no 2529 0.152378795941017 4081 16192618 SGTC_2021 4019055 173 µM -1.02791977102621 0.266929545014138 no 2530 0.151993784261574 3984 44827708 YER133W GLC7 SGTC_1405 3909-7894 12 µM -1.02890136439425 0.266753790825314 no 2531 0.151763013588924 4117 7104060 SGTC_3330 9141424 71.43 µM -1.03555039048813 0.265564825320136 no 2532 0.150205973175774 4206 27261020 SGTC_2256 7954252 200 µM -1.03580417295753 0.265519497761689 no 2533 0.150146755194621 4148 2972920 SGTC_1961 st076550 68.7 µM -1.0363130572538 0.265428618824048 no 2534 0.150028058267258 4155 1579337 SGTC_3040 9091894 49.47 µM -1.03827374664969 0.265078617365893 no 2535 0.149571313791242 3980 25236966 SGTC_1814 st052110 31.539 µM -1.04017240582443 0.264739912458 no 2536 0.149129904564817 4086 674163 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.04107037210236 0.264579799474518 no 2537 0.148921444487505 4170 6708784 An antioxidant flavonoid SGTC_381 3461-2219 42.7 µM -1.04211664298716 0.264393305014649 no 2538 0.148678801655154 4139 2883159 SGTC_1428 4049-0204 61.7 µM -1.0426091739755 0.264305536100682 no 2539 0.148564669317664 4188 X1428 SGTC_970 1315-0089 19.5 µM -1.0426590920319 0.264296641541998 no 2540 0.148553105266041 4081 6811083 YLR033W RSC58 SGTC_1965 Pectolinarigenin 58.4 µM -1.04268380425091 0.264292238296307 no 2541 0.14854738063895 4097 5320438 An anti-inflammatory. SGTC_1057 3448-5381 134 µM -1.04282541338791 0.264267006971601 no 2542 0.148514579488622 4119 5497911 SGTC_546 peri-Naphthalide 147 µM -1.04490290996104 0.263896988354088 no 2543 0.148033922369371 4064 223824 A penicillin ester. SGTC_467 ro 31-8220 72.8 µM -1.04593201126573 0.263713795115451 no 2544 0.147796211804872 4074 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2357 9067248 200 µM -1.04635965345528 0.263637688399554 no 2545 0.147697506592388 4122 9150235 SGTC_866 0495-0101 262 µM -1.04743596269952 0.263446189171518 no 2546 0.147449276263096 4120 635694 SGTC_3182 9108849 49.47 µM -1.04798300445319 0.263348885562839 no 2547 0.147323218653855 4179 17133045 SGTC_438 sphingosine 6.67 µM -1.04990686039356 0.263006830574029 no 2548 0.146880468554977 4081 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_3237 9133362 49.47 µM -1.05002769445737 0.262985354273661 no 2549 0.146852690007317 4112 43845137 SGTC_2532 xanthone 78.9 µM -1.05018405252654 0.262957565486452 no 2550 0.146816750075423 4142 7020 An insecticide. SGTC_1244 0416-0015 52.5 µM -1.05040311214344 0.262918635571714 no 2551 0.146766407704915 4113 96201 SGTC_2995 9067767 71.4286 µM -1.05060637846851 0.262882514978525 no 2552 0.146719705171014 4153 11673567 SGTC_1893 st059353 36.1 µM -1.05138212617446 0.262744687296697 no 2553 0.146541560789012 4162 3112488 SGTC_752 1896-0090 130 µM -1.05952775794882 0.261299681953596 no 2554 0.144679747276364 4142 772567 SGTC_1463 k081-0032 34.1 µM -1.06089539342438 0.261057469296987 no 2555 0.144368721503001 3806 977755 SGTC_1434 4073-0095 163 µM -1.06585559830847 0.260179970463642 no 2556 0.143244461633464 4109 24133745 SGTC_3280 9140961 49.47 µM -1.06814175316739 0.259776044300096 no 2557 0.142728287077869 4190 4901226 SGTC_255 tunicamycin 200.472 nM -1.06901245919498 0.259622289924369 no 2558 0.142532027656231 4086 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3034 9090421 49.47 µM -1.06972053898444 0.25949728769022 no 2559 0.142372559237742 4062 17173761 SGTC_2543 pimpinellin 60.67 µM -1.07154728439163 0.259174943250499 no 2560 0.14196171087588 3982 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_528 3492-0019 172 µM -1.07212313350066 0.259073372804979 no 2561 0.141832364773714 4158 2869262 SGTC_2879 9041815 71.43 µM -1.07455187912168 0.258645208046387 no 2562 0.141287703001453 4174 4942971 SGTC_224 benfluorex 43.875 µM -1.07493857179188 0.258577071629205 no 2563 0.141201115709413 4200 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2955 9076254 12.21 µM -1.07507670296553 0.258552734752252 no 2564 0.141170194432378 4081 16459619 SGTC_1922 5578187 25 µM -1.07600480076622 0.258389247020223 no 2565 0.14096255467679 4187 1350412 SGTC_1383 3049-0032 20.7 µM -1.07724800032681 0.258170336945515 no 2566 0.140684743156266 4226 712864 SGTC_612 0302-0167 22.4 µM -1.07949434609677 0.257775030808936 no 2567 0.140183706442129 4176 235821 SGTC_372 0155-0182 15.9 µM -1.07986630191366 0.257709605313547 no 2568 0.140100860584668 4069 771486 SGTC_1197 1601-0112 267 µM -1.08041368770849 0.257613338088349 no 2569 0.139979001649005 4134 7350313 SGTC_1178 0988-0033 191 µM -1.08044639687957 0.25760758620825 no 2570 0.13997172221998 4217 5392207 SGTC_448 monastrol 171 µM -1.08225945537022 0.257288865734402 no 2571 0.139568628179171 4091 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1828 st055811 49 µM -1.08245677448157 0.257254191060953 no 2572 0.139524806257131 4188 5877589 SGTC_309 k408-0051 1.48 µM -1.08319400686063 0.257124659510673 no 2573 0.139361159660539 4115 3640463 SGTC_2407 paclitaxel 400 µM -1.08456214603697 0.256884367691713 no 2574 0.139057814145888 4287 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3014 9081533 49.47 µM -1.08584870720697 0.256658510406383 no 2575 0.13877296656074 4222 21367265 SGTC_2074 5212007 75.395 µM -1.08597667954594 0.256636050371361 no 2576 0.138744654938028 4078 758611 SGTC_1554 st069299 38.7 µM -1.08644206926358 0.256554379870948 no 2577 0.13864172884133 4154 24207999 SGTC_670 4204-0025 119 µM -1.08786962216516 0.256303945363002 no 2578 0.138326334237456 4188 719039 SGTC_174 3553-0389 74.3 µM -1.08913710286079 0.256081699039088 no 2579 0.13804671517122 4261 738071 SGTC_2259 7964009 200 µM -1.09049138775835 0.255844343162456 no 2580 0.137748372484985 4222 313134 SGTC_747 3448-8087 38.7 µM -1.09093313691016 0.255766945775359 no 2581 0.137651152427796 4225 5168703 SGTC_3021 9087658 49.47 µM -1.09166835262847 0.255638158201708 no 2582 0.137489450164434 4196 25237042 SGTC_771 0250-0039 27.3 µM -1.09331636185178 0.25534959987868 no 2583 0.137127460731536 4154 3005115 SGTC_751 0833-0568 350 µM -1.09425747036835 0.255184892799697 no 2584 0.136921036171587 4206 6954252 SGTC_1262 0737-0114 49.6 µM -1.09456763612353 0.255130621653416 no 2585 0.136853050368998 4260 765919 SGTC_917 harmaline 728.087 nM -1.09541350289451 0.254982647090847 no 2586 0.136667760554312 4146 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2986 9022445 71.43 µM -1.0970539067805 0.254695805530086 no 2587 0.136308913923836 4196 6459286 SGTC_2690 usnic acid 100 µM -1.09745927882029 0.254624948088708 no 2588 0.136220336172261 4225 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.09861497489416 0.254422993642498 no 2589 0.135968021548681 4199 5024745 SGTC_3246 9135460 32.98 µM -1.0994451204219 0.254277980005883 no 2590 0.135786979562904 4159 41446951 SGTC_1648 st011736 69.8 µM -1.10335774542608 0.253595088543018 no 2591 0.134935919394903 4184 2855514 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.10395809387458 0.253490391818808 no 2592 0.134805658242189 4204 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1822 st052468 42 µM -1.10645018396712 0.253056031036552 no 2593 0.134265857291525 4190 2873678 SGTC_1195 1502-0147 41.1 µM -1.1067214833636 0.253008768342382 no 2594 0.134207182020609 4168 817940 SGTC_1168 k815-0004 80.5 µM -1.10743067955603 0.252885242193534 no 2595 0.13405388383476 4172 642433 SGTC_997 3996-0078 137 µM -1.10758043503197 0.252859162191722 no 2596 0.134021528432833 4250 735687 SGTC_730 1436-0052 41.2 µM -1.10842035265319 0.252712916299583 no 2597 0.13384015957355 4232 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1564 D-Arginine 115 µM -1.11135176309123 0.252202850303199 no 2598 0.133208483334163 4218 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_3315 9136395 68.55 µM -1.11315030925103 0.251890171866422 no 2599 0.132821939898585 4209 16876844 SGTC_39 0986-0283 58.349 µM -1.11894853560611 0.250883541168509 no 2600 0.131581047590563 4294 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1186 1319-0216 26 µM -1.12075471158668 0.250570406291429 no 2601 0.131196143247706 4284 4565136 SGTC_3197 9113331 49.47 µM -1.12321054384815 0.25014497356447 no 2602 0.130674042792193 4235 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2789 5281112 71.43 µM -1.12330890528684 0.250127942039379 no 2603 0.13065316149042 4239 765948 SGTC_397 arbidol 50 µM -1.12479063453458 0.249871451418435 no 2604 0.1303388820136 4263 131410 A RNA synthesis inhibitor. SGTC_1106 tegaserod maleate 11.7 µM -1.1263942250286 0.249594023733679 no 2605 0.129999345059643 4235 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1780 st038448 24.544 µM -1.12813646801857 0.249292794168637 no 2606 0.129631144953504 4268 728868 YDL195W SEC31 SGTC_2116 5511452 16.8835 µM -1.12945314288679 0.249065272594322 no 2607 0.129353362732662 4245 870744 SGTC_1359 1582-0056 520 nM -1.12999368514185 0.248971898824483 no 2608 0.129239442694138 4274 3661189 SGTC_1632 st005650 90 µM -1.13335112176441 0.24839234954171 no 2609 0.128533415725407 4248 2759605 SGTC_1185 1319-0113 81.3 µM -1.13373734184026 0.248325727692828 no 2610 0.128452370482145 4292 4672763 SGTC_2945 9067681 61.76 µM -1.13412165789477 0.248259443738928 no 2611 0.128371760000532 4302 16456930 SGTC_441 propafenone 146 µM -1.1342920707429 0.248230055226849 no 2612 0.12833602706337 4210 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_6 0844-0013 19.835 µM -1.13703297765928 0.247757627680465 no 2613 0.12776224995438 4363 1584900 SGTC_3323 9138564 53.9225 µM -1.13804391400315 0.24758350217648 no 2614 0.127551072905689 4244 43912313 YNL103W MET4 SGTC_1274 0865-0114 173 µM -1.13807929712744 0.247577408907478 no 2615 0.127543686033848 4218 870624 SGTC_1451 4152-0210 104 µM -1.1420152679035 0.246900102307397 no 2616 0.126723836694861 4280 659563 SGTC_1378 2093-0007 380 nM -1.14767984666709 0.245927078039273 no 2617 0.125550376927446 4294 3618014 SGTC_2417 cerulenin 830 nM -1.14848178952808 0.245789492019139 no 2618 0.125384863213922 4255 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1038 k292-0204 154 µM -1.14929745216257 0.24564959455389 no 2619 0.125216674166912 4190 4454212 SGTC_2629 bisabolol 100 µM -1.14967445483007 0.245584947815838 no 2620 0.125138989744534 4278 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_761 k216-0224 480 µM -1.15016420244453 0.245500981724464 no 2621 0.125038123591074 4283 1340404 SGTC_1979 st071809 45.3 µM -1.15178819860694 0.245222661758056 no 2622 0.124704059269811 4309 4976333 SGTC_500 h-89 112 µM -1.15330896438629 0.244962187276421 no 2623 0.124391795991956 4246 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_894 0960-0238 55.9 µM -1.15393763558149 0.244854552922532 no 2624 0.124262868974125 4244 6741907 YDL195W SEC31 SGTC_122 0236-0016 402.397 µM -1.15548912294864 0.244589032816258 no 2625 0.123945092142962 4237 6808838 SGTC_280 3448-3607 3.04 µM -1.15732406909439 0.244275202110601 no 2626 0.12356999170745 4204 626179 SGTC_2965 9082772 38.63 µM -1.15957067752886 0.243891260596012 no 2627 0.123111822586404 4268 16459634 SGTC_3128 9127691 49.47 µM -1.15997412188804 0.243822347155328 no 2628 0.123029671173591 4281 41316314 SGTC_1107 amlodipine 47 µM -1.16042031735615 0.243746143520596 no 2629 0.122938859322041 3922 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2935 9038016 29.96 µM -1.16213954972855 0.243452644118852 no 2630 0.122589392319889 4231 6463195 SGTC_1727 st034309 9.9045 µM -1.16508435988965 0.242950363667037 no 2631 0.121992423528321 4322 870305 SGTC_1659 st012954 42.1 µM -1.16523002127084 0.242925533546874 no 2632 0.121962948292451 4201 24207262 SGTC_536 3852-0578 10.6 µM -1.16781195549672 0.242485632907666 no 2633 0.121441312277228 4310 2869208 SGTC_32 0928-0142 34.1 µM -1.16815311438042 0.242427539778449 no 2634 0.121372504404265 4236 2244242 SGTC_2374 9071832 200 µM -1.17147130684582 0.241862905682787 no 2635 0.120704692330472 4182 17381698 SGTC_248 streptozotocin 5.23457 mM -1.17276164979496 0.241643529694303 no 2636 0.120445700559878 4285 5300 DNA alkylating agent. SGTC_2928 9011484 9.79 µM -1.17293287178204 0.24161442772987 no 2637 0.120411363095865 4268 2994751 SGTC_1357 1503-1303 39.5 µM -1.17319849373977 0.241569284719522 no 2638 0.120358107972882 4235 292895 SGTC_1235 benzylparaben 21.5 µM -1.1749706496806 0.241268220331915 no 2639 0.120003229161227 4285 7180 SGTC_2217 6934799 96.0675 µM -1.17714785345727 0.240898623321207 no 2640 0.1195682489572 4241 675606 SGTC_2779 methotrexate 400 µM -1.17730398425634 0.240872130762939 no 2641 0.119537098617619 4281 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2172 5754775 163.918 µM -1.17876707305998 0.240623948225698 no 2642 0.119245469530023 4249 2263357 SGTC_2839 9003951 25.97 µM -1.18042969112333 0.240342088764712 no 2643 0.118914679400031 4314 2990634 SGTC_1122 capsaicin 818.572 nM -1.18066662689472 0.240301936286637 no 2644 0.118867592087702 4320 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1568 digitonin 820 nM -1.18075379437761 0.240287165310854 no 2645 0.118850272215491 4254 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2957 9076800 11.52 µM -1.18415061844062 0.239711941540804 no 2646 0.118176722895227 4241 16459615 SGTC_1082 camptothecin 424.86 nM -1.186811298496 0.239261902941966 no 2647 0.117651030593463 4160 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_721 1187-1332 279 µM -1.19057200101992 0.238626590043914 no 2648 0.116910824352435 4232 25730 SGTC_295 k015-0027 31 µM -1.1922913664033 0.23833643750638 no 2649 0.116573509313074 4333 3887424 SGTC_3176 9106582 49.47 µM -1.192427565516 0.238313461405687 no 2650 0.116546818516773 4250 17018027 SGTC_2310 7668677 200 µM -1.19394098352309 0.238058237105159 no 2651 0.11625052721341 4291 2197143 SGTC_1844 rapamycin 4 nM -1.19518128383491 0.237849183389607 no 2652 0.116008104692155 4160 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_931 2812-0076 566 µM -1.19638058430554 0.237647136009559 no 2653 0.115774037271555 4221 3450959 SGTC_287 k060-0039 29.6 µM -1.19757165932024 0.2374465676226 no 2654 0.115541907372131 4320 5861974 SGTC_675 1309-0189 238 µM -1.19770398420078 0.23742429081009 no 2655 0.115516138856921 4304 4246530 SGTC_699 0375-0592 111 µM -1.20004716595185 0.237030007711669 no 2656 0.115060511510782 4355 762578 SGTC_555 4296-0685 37 µM -1.2018290811935 0.236730408989237 no 2657 0.114714877867287 4260 2908540 YHR072W ERG7 SGTC_1798 st045719 60.953 µM -1.20237184230763 0.236639194344044 no 2658 0.114609746782488 4232 3980186 SGTC_98 0074-0023 107.663 µM -1.20693971655795 0.235872299057573 no 2659 0.113727680407583 4300 3563821 SGTC_3122 9126309 49.47 µM -1.20755359716755 0.235769339863254 no 2660 0.113609508584748 4345 17591206 SGTC_2927 9011802 47.9 µM -1.21112882306248 0.235170200690615 no 2661 0.112923018163279 4295 43912568 SGTC_753 1322-0200 289 µM -1.21122057409323 0.235154836054446 no 2662 0.112905439811842 4357 5403907 SGTC_2477 5967686 25.23 µM -1.21152802122496 0.235103354970626 no 2663 0.112846551020824 4280 776118 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.21196977211039 0.235029396032659 no 2664 0.112761975921262 4297 3256 An antibiotic and ribosome inhibitor. SGTC_3168 9103419 49.47 µM -1.21307886845605 0.234843765258722 no 2665 0.112549834159875 4318 16649256 SGTC_260 nsc-65238 3.989 µM -1.21396544724684 0.234695435811783 no 2666 0.112380459451722 4296 3246252 SGTC_1984 st072354 53.1 µM -1.21528660300538 0.234474495423459 no 2667 0.112128399864183 4173 5762938 SGTC_620 0109-0052 432 µM -1.21624988170724 0.234313476330763 no 2668 0.111944873550566 4323 493037 SGTC_1033 k072-0102 21.3 µM -1.21699048485015 0.234189720716181 no 2669 0.111803918076352 4268 5965931 SGTC_263 alizarin 107.927 µM -1.21964647281595 0.233746199897175 no 2670 0.111299460557975 4334 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1098 clofazimine 15.1 µM -1.22328382335933 0.233139558445228 no 2671 0.110611257451744 4364 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2566 crystal violet carbinol 226 nM -1.22417530096238 0.232991010273361 no 2672 0.110443052232535 4313 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_21 0849-0113 22.993 µM -1.22599452133095 0.232688034165917 no 2673 0.110100368371065 4265 1560156 SGTC_2257 7960413 200 µM -1.22631808153862 0.23263417083538 no 2674 0.110039499795485 4334 2974689 YIL048W NEO1 SGTC_2605 digitonin 300 nM -1.2263639436412 0.232626536694794 no 2675 0.11003087410987 4320 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1148 3909-7663 27.7 µM -1.22765649239189 0.232411438142675 no 2676 0.10978797266407 4362 4084526 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.22784624543786 0.232379869843559 no 2677 0.109752345861908 4360 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1188 1403-0014 4.57 µM -1.2282792428219 0.23230784308896 no 2678 0.10967108015604 4300 9614867 SGTC_1137 ixabepilone 100 µM -1.22991075972515 0.232036560746383 no 2679 0.109365262282916 4269 154225 A novel microtubule stabilizer. SGTC_2367 9070478 135.38 µM -1.2306139749328 0.231919687247426 no 2680 0.109233637976158 4242 572802 SGTC_297 0986-0032 24 µM -1.2307281869786 0.231900708441623 no 2681 0.109212271084958 4264 2847425 SGTC_2022 5136654 200 µM -1.23118803277844 0.231824303852342 no 2682 0.109126273109676 4333 1713771 SGTC_1327 1436-0082 2.18 µM -1.232902356023 0.231539588154116 no 2683 0.108806098173544 4317 15992205 SGTC_2462 5162487 171.77 µM -1.23351180588771 0.231438417388717 no 2684 0.108692437403401 4269 2259986 SGTC_1640 st009078 66.4 µM -1.23472930294834 0.231236382531005 no 2685 0.108465633185671 4290 690618 SGTC_2595 hexamethylquercetagetin 100 µM -1.23596025258344 0.231032215383114 no 2686 0.10823666928513 4325 386331 SGTC_1758 st042942 75.2445 µM -1.2362224775269 0.230988735365832 no 2687 0.108187938876854 4283 669317 SGTC_1388 3346-4487 254 µM -1.24387119310258 0.229722498958228 no 2688 0.106773486510716 4390 3345614 SGTC_778 3456-2434 196 µM -1.24517505236499 0.229507034981453 no 2689 0.106533705413255 4272 5539063 SGTC_2054 5233173 129 µM -1.24929896143674 0.228826301132807 no 2690 0.10577787382754 4356 6889 SGTC_944 3370-0224 231 µM -1.2496795033365 0.22876354223216 no 2691 0.105708323815734 4325 4580514 SGTC_2606 farnesol 9.78 µM -1.25055666712913 0.228618917354078 no 2692 0.105548134296265 4349 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.2508226969012 0.228575065088234 no 2693 0.105499586084767 4359 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_3328 9140624 29.0385 µM -1.2520218815498 0.22837745051776 no 2694 0.105280945378242 4337 4904392 SGTC_2675 theaflavin digallate 100 µM -1.25271829818376 0.228262731561234 no 2695 0.105154122157955 4264 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_3084 9116877 49.47 µM -1.25287627171623 0.228236713487448 no 2696 0.105125369263128 4277 27241325 SGTC_77 0828-0286 12.516 µM -1.253391214131 0.228151914591276 no 2697 0.105031683666198 4230 745345 SGTC_433 pimozide 108 µM -1.2554699699842 0.227809772587551 no 2698 0.104654101440587 4251 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_65 0798-0905 34.986 µM -1.25547914761241 0.227808262684067 no 2699 0.104652436612129 4384 3602145 SGTC_468 gf-109203x 121 µM -1.25629014140035 0.227674860217172 no 2700 0.104505397479929 4352 2396 A protein kinase C inhibitor. SGTC_2183 6420625 130.508 µM -1.25863096577824 0.227290058716112 no 2701 0.104081828440401 4347 2897619 SGTC_3056 9094900 49.47 µM -1.25919246179005 0.227197810500763 no 2702 0.10398041183954 4314 25236784 SGTC_1775 st081588 35.1725 µM -1.26381777088675 0.226438721526967 no 2703 0.103147720615421 4329 1426443 YGL099W LSG1 SGTC_2260 7964312 200 µM -1.26472517739406 0.226289969481241 no 2704 0.102984930644865 4395 231951 SGTC_1643 st009866 20.2 µM -1.26584080578342 0.226107159095279 no 2705 0.102785041272247 4293 3156273 YOR207C RET1 SGTC_188 3229-0966 278.469 µM -1.26604215437225 0.226074174374203 no 2706 0.10274899529638 4378 5722370 SGTC_457 grayanotoxin iii 135 µM -1.26640223700224 0.22601519278545 no 2707 0.102684555224195 4188 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_52 0329-0193 875 nM -1.26713707969203 0.225894852436725 no 2708 0.102553139568332 4392 3739292 SGTC_1524 corynanthine 62.1 µM -1.26786152288685 0.225776250619258 no 2709 0.102423703433352 4421 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1199 1638-0010 4.46 µM -1.26813557090496 0.225731394183114 no 2710 0.102374770304396 4310 3111136 SGTC_3157 9099274 49.47 µM -1.27024800705714 0.225385797907849 no 2711 0.101998151021797 4367 17217662 SGTC_567 1080-0542 68.4 µM -1.27032916929377 0.225372525678613 no 2712 0.101983701013463 4228 5950415 SGTC_1656 st012921 11 µM -1.27334910839905 0.224878998310971 no 2713 0.101447093870046 4239 6732821 SGTC_1453 4237-0541 195 µM -1.27334944386962 0.224878943521435 no 2714 0.101447034375389 4338 739892 SGTC_2916 7875993 68.79 µM -1.27624571426523 0.224406202612798 no 2715 0.100934336687409 4192 1299250 SGTC_1980 st071811 45.7 µM -1.27715279222487 0.224258261768473 no 2716 0.100774154891205 4421 4974850 SGTC_1324 1418-0026 34.4 µM -1.2776091912149 0.224183845835477 no 2717 0.100693629079256 4390 1372513 SGTC_117 lucigenin 22.078 µM -1.27779021711053 0.224154333416911 no 2718 0.100661702358787 4340 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_803 4488-1585 147 µM -1.27876826738852 0.223994921309187 no 2719 0.100489335749267 4354 747204 SGTC_1682 st012968 530 nM -1.27970776285919 0.223841853907207 no 2720 0.100323966716561 4355 24207270 SGTC_288 1315-0019 35.1 µM -1.28129819067084 0.223582868835219 no 2721 0.100044474087488 4377 6811474 SGTC_1949 st076024 69.1 µM -1.28133967737461 0.223576115426831 no 2722 0.100037191069419 4296 2921930 SGTC_919 tnp00227 403.569 nM -1.28239380552245 0.223404558223904 no 2723 0.0998522680496241 4300 1269246 A methoxyflavone. YNL221C POP1 SGTC_2891 9063876 19.48 µM -1.28292783771547 0.223317674167663 no 2724 0.0997586794846918 4372 6472478 SGTC_1387 3342-1166 1.8 µM -1.28703393359156 0.222650277974414 no 2725 0.09904123043549 4326 3418228 SGTC_9 0092-0002 10.449 µM -1.29332848094531 0.221629386196664 no 2726 0.0979487370982252 4359 759368 SGTC_698 k064-0052 127 µM -1.2941245264542 0.221500469026825 no 2727 0.0978112054984047 4449 5088751 SGTC_3278 9139605 49.47 µM -1.29419059701905 0.221489771025005 no 2728 0.0977997969503379 4343 7958859 SGTC_3055 9094636 49.47 µM -1.29553372410413 0.221272358859041 no 2729 0.0975680877056471 4397 25236176 SGTC_660 4031-1742 102 µM -1.29668633167255 0.22108588347199 no 2730 0.0973695670789416 4253 6738706 SGTC_3208 9114115 49.47 µM -1.29856451604032 0.220782212897023 no 2731 0.0970467110398897 4361 650895 SGTC_2849 9019321 12.99 µM -1.30097589206609 0.220392684684965 no 2732 0.0966333534015049 4392 16489627 SGTC_2549 cedrol 20.94 µM -1.30258928200374 0.22013228144102 no 2733 0.0963575094298067 4312 6708665 A sedative which affects the nervous system. SGTC_851 0394-0702 453 µM -1.30277449452253 0.220102399194684 no 2734 0.0963258804009764 4375 762646 SGTC_1144 3486-0183 12.5 µM -1.30311294589297 0.220047799354814 no 2735 0.0962681022483944 4383 6744069 SGTC_1499 4480-0877 67.3 µM -1.30416696088371 0.219877812749831 no 2736 0.0960883310563721 4356 2861909 SGTC_1622 st003707 19.4 µM -1.30541476309206 0.219676670504553 no 2737 0.0958758270237826 4384 10140899 SGTC_701 4424-0219 185 µM -1.30611143585426 0.219564414770304 no 2738 0.0957573322743622 4387 2911779 SGTC_691 1548-0686 185 µM -1.30663947275275 0.219479353492873 no 2739 0.095667592038758 4339 46495133 SGTC_2033 5192550 145 µM -1.30764834760584 0.219316886848271 no 2740 0.0954963051474013 4372 182073 SGTC_2845 9003024 42.97 µM -1.30908937181905 0.219084947875257 no 2741 0.0952520394905116 4418 2990173 SGTC_2715 st079500 56.4 µM -1.31142805284596 0.218708827587077 no 2742 0.0948565931633246 4346 28246688 SGTC_3179 9107801 49.47 µM -1.31211461628564 0.218598481066688 no 2743 0.0947407325226827 4372 4818259 SGTC_2909 7941780 10.49 µM -1.31266426558892 0.218510162899955 no 2744 0.09464805194821 4341 1243215 SGTC_2981 9013952 38.96 µM -1.31360338251335 0.218359312262851 no 2745 0.094489854920797 4331 2996344 SGTC_3353 9151644 39.2805 µM -1.31380445356797 0.218327021956992 no 2746 0.0944560092591531 4382 4909158 SGTC_3186 9110464 49.47 µM -1.31440988666181 0.218229811150298 no 2747 0.0943541525808873 4362 17018021 SGTC_1014 4130-3005 69.3 µM -1.31740844015955 0.217748718976397 no 2748 0.0938508766642832 4396 743608 SGTC_2276 7947513 42.08 µM -1.31819255528882 0.217623015422742 no 2749 0.0937195985256741 4312 2105100 SGTC_1149 3909-7961 23.3 µM -1.31975019861359 0.21737342979094 no 2750 0.09345921697348 4436 735261 SGTC_1217 1183-1422 255 µM -1.32028692066732 0.21728746758795 no 2751 0.0933696203758397 4410 2849664 SGTC_2020 4017018 200 µM -1.32086092489481 0.217195555945997 no 2752 0.0932738703885319 4426 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1647 st011722 22.4 µM -1.322438385809 0.216943082872283 no 2753 0.0930111068708085 4344 2854783 SGTC_1466 k213-0079 57.5 µM -1.3272639373986 0.21617180593987 no 2754 0.0922106943660852 4338 3657981 SGTC_2335 9018011 154.17 µM -1.33229479246587 0.215369408166973 no 2755 0.0913816688454804 4370 6458208 SGTC_1899 st063254 59.6 µM -1.33463064881459 0.214997438254084 no 2756 0.0909986308927631 4341 3093813 SGTC_2262 9014885 67.46 µM -1.33581926014263 0.214808302948666 no 2757 0.0908041780603425 4404 6457424 SGTC_315 k915-0449 187 µM -1.33771798294522 0.214506373258183 no 2758 0.0904941932984174 4422 20970215 YNL149C PGA2 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.33778244974734 0.214496126256897 no 2759 0.0904836822804024 4386 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2994 9053520 71.4286 µM -1.33788965089204 0.214479087259935 no 2760 0.090466205629688 4427 4647384 SGTC_2744 captopril 92.04 µM -1.33926365344624 0.214260767258921 no 2761 0.0902424283804717 4453 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_893 0958-0369 48.9 µM -1.34333806038616 0.213614131264003 no 2762 0.0895812666376795 4297 6819948 SGTC_1875 nocodazole 6 µM -1.34785237426418 0.212899008560993 no 2763 0.0888529343377662 4430 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_3047 9092122 49.47 µM -1.34970055460864 0.212606637693032 no 2764 0.0885560271935114 4367 17173831 SGTC_451 chloral hydrate 100 µM -1.35081921595868 0.212429786260721 no 2765 0.0883766754980906 4406 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_624 k048-0052 28 µM -1.35128221098185 0.212356615597875 no 2766 0.0883025241118178 4387 6835531 SGTC_2323 6148992 148.28 µM -1.35479863906783 0.211801368328471 no 2767 0.0877408601692902 4362 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_549 1661-1316 519 µM -1.36307691212332 0.210497580137823 no 2768 0.0864291361411576 4425 2857282 SGTC_2646 retinol 96.75 µM -1.36594637961717 0.21004675450881 no 2769 0.0859778969772049 4408 445354 A vitamin A analog and teratogen. SGTC_1938 st074717 56.4 µM -1.3678859519602 0.209742347452729 no 2770 0.085673888834338 4281 17250979 SGTC_2953 9074162 66.49 µM -1.36886775745954 0.209588356478255 no 2771 0.0855203079877144 4396 16451992 SGTC_2297 7971671 152.32 µM -1.36898645226085 0.209569744336124 no 2772 0.0855017548993859 4404 909016 SGTC_745 0469-0705 296 µM -1.36925879567048 0.209527042734747 no 2773 0.085459196514503 4449 3486736 SGTC_1884 5633444 25 µM -1.36936052172517 0.209511094091649 no 2774 0.085443304123231 4363 5724239 SGTC_2105 5350118 200 µM -1.37308059698527 0.208928350251638 no 2775 0.0848636461423676 4385 2133313 SGTC_2908 7930301 100 µM -1.37348670069488 0.208864792612219 no 2776 0.0848005464400346 4375 2223178 SGTC_3083 9117465 49.47 µM -1.37350588682716 0.208861790150539 no 2777 0.0847975662020031 4380 16420915 SGTC_2027 5150920 200 µM -1.37590280992175 0.208486892744645 no 2778 0.084425862585466 4357 786715 SGTC_1260 0700-1617 7.75 µM -1.38215927334323 0.207510204804532 no 2779 0.0834614010161222 4399 2853078 SGTC_2677 mitomycin C 100 µM -1.38242424199831 0.207468900686025 no 2780 0.0834207384566625 4497 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2167 5876490 200 µM -1.38281612913774 0.207407821038076 no 2781 0.083360626060899 4470 686534 SGTC_1238 0333-0287 48.8 µM -1.38355546250338 0.207292617266043 no 2782 0.0832473068243676 4418 7226 SGTC_521 r062-0005 13.8 µM -1.38642850424551 0.206845295962843 no 2783 0.0828080488095179 4348 2832033 SGTC_2115 tiliquinol 12.7705 µM -1.39173798387919 0.206020136117212 no 2784 0.0820008778099528 4413 71208 A bioactive hydroxyquinoline. SGTC_506 n9-isopropylolomoucine 153 µM -1.39340944912715 0.205760773989135 no 2785 0.0817480049802664 4421 6610355 SGTC_3325 9138760 55.175 µM -1.3938880884181 0.205686538984085 no 2786 0.0816757009191347 4379 43844959 SGTC_3124 9127567 49.47 µM -1.40273061692836 0.204317960410301 no 2787 0.0803485918789665 4399 17592030 SGTC_1784 st039334 36.3 µM -1.40278689954874 0.204309266819326 no 2788 0.0803401973415158 4437 3496984 SGTC_1226 3909-7979 35.4 µM -1.40284092670717 0.204300921821292 no 2789 0.0803321398290353 4424 6615510 SGTC_1997 st073024 93.8 µM -1.40431669027022 0.204073054879009 no 2790 0.0801122832052807 4481 686268 SGTC_3253 9135987 49.47 µM -1.40512276399305 0.203948656112827 no 2791 0.0799923880154441 4437 4182430 SGTC_1908 st060353 56.5 µM -1.40539392183366 0.203906819353987 no 2792 0.0799520865813554 4462 4227716 SGTC_3165 9101544 49.47 µM -1.40539434470615 0.203906754113273 no 2793 0.0799520237429891 4434 5002184 SGTC_586 0957-0265 8.15 µM -1.40697826847207 0.20366247384943 no 2794 0.0797169164329967 4332 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_37 0566-0070 1.56 µM -1.41193263978276 0.202899514455479 no 2795 0.0789848979994078 4364 1626686 SGTC_769 0302-0231 76 µM -1.41264651775249 0.202789720127334 no 2796 0.0788798420985345 4345 571869 YER009W NTF2 SGTC_404 fumagillin 50 µM -1.41509558669223 0.202413323544424 no 2797 0.0785202360052664 4443 12015870 A methionine aminopeptidase binder. SGTC_191 3914-0123 66.505 µM -1.41667925860882 0.202170152104233 no 2798 0.0782883619399114 4487 3144412 SGTC_2808 7946468 45.46 µM -1.41709142189441 0.202106893467241 no 2799 0.0782281001018574 4433 2970879 SGTC_938 3126-1755 342 µM -1.41804754514766 0.201960193711089 no 2800 0.0780884420824654 4443 1777771 SGTC_522 1273-0010 11.6 µM -1.41837829984149 0.201909460249853 no 2801 0.0780401738071535 4466 5705015 SGTC_3181 9108277 49.47 µM -1.41862571843114 0.201871514450071 no 2802 0.0780040818844816 4410 17097298 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.41889455375725 0.201830288874031 no 2803 0.0779648801760018 4479 94937 An inhibitor of serotonin biosynthesis. SGTC_2119 5528445 120.635 µM -1.41957123058261 0.201726543606768 no 2804 0.077866272976013 4475 791935 SGTC_3289 9119912 71.43 µM -1.4225592466081 0.201268815479906 no 2805 0.0774319825262347 4443 17014829 SGTC_1127 asiatic acid 681.4 nM -1.42398751495771 0.201050242072241 no 2806 0.0772250431171057 4412 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2536 dehydroabietamide 32.04 µM -1.42509429600344 0.200880965057708 no 2807 0.0770649726326433 4501 3983547 SGTC_2682 pyrogallin 40.03 µM -1.42867614617478 0.200333724261563 no 2808 0.0765486684685767 4458 822798 An ATP competetive kinase inhibitor. SGTC_391 gliotoxin 8.33 µM -1.42871742607221 0.200327422677905 no 2809 0.0765427335705283 4500 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1616 st002734 56.1 µM -1.43205826457359 0.199817821819523 no 2810 0.0760635736706081 4408 4026101 SGTC_2363 9053361 176 µM -1.43237827578252 0.199769049284833 no 2811 0.076017796161286 4498 6469797 YMR079W SEC14 SGTC_3008 9078912 71.4286 µM -1.43246581162959 0.199755709296061 no 2812 0.0760052778384032 4468 16648731 SGTC_186 3455-3465 67.277 µM -1.43545495071223 0.199300502347896 no 2813 0.0755787484095677 4459 755278 SGTC_2466 5983409 37.09 µM -1.43818122206913 0.198885871898259 no 2814 0.0751913208682976 4447 2879657 SGTC_1529 apigenin 74 µM -1.43905899966027 0.198752484062041 no 2815 0.0750669036180922 4456 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_783 0848-0141 92.7 µM -1.44153208798067 0.198376961605074 no 2816 0.0747172094053974 4389 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1112 tnp00069 1.16933 µM -1.44457665674789 0.197915251977775 no 2817 0.0742884167530611 4440 145826 SGTC_2201 6605497 169.863 µM -1.4539090291935 0.19650404490124 no 2818 0.0729857645861256 4416 670741 SGTC_53 0973-0023 39.979 µM -1.45498748385003 0.196341358893863 no 2819 0.0728363632707177 4367 674768 SGTC_3200 9114385 49.47 µM -1.45504034059765 0.196333387497861 no 2820 0.0728290469021792 4445 17018030 YLR208W SEC13 SGTC_1085 doxorubicin 7.67 µM -1.45620395238797 0.196157951367363 no 2821 0.0726681236313913 4474 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_284 0988-0104 32.6 µM -1.45642518801266 0.196124606738773 no 2822 0.0726375583822687 4438 4666532 SGTC_84 0443-0269 128.823 µM -1.46422705858189 0.194950908199791 no 2823 0.0715659596587478 4418 6150058 SGTC_1220 1838-0075 193 µM -1.46465136190133 0.194887199506774 no 2824 0.0715080306107879 4410 5529645 SGTC_3140 9094243 49.47 µM -1.46750978814554 0.194458339876994 no 2825 0.0711187142733346 4425 19291112 SGTC_1125 tnp00248 1.32998 µM -1.4708904808052 0.193951864941886 no 2826 0.070660368713393 4502 24207736 SGTC_2497 7-hydroxyflavone 100 µM -1.47306880776808 0.193625947427625 no 2827 0.0703662415878162 4489 5281894 SGTC_379 3970-0972 5.9 µM -1.47487063092954 0.1933566143052 no 2828 0.0701236637699312 4479 2898042 YBL034C STU1 SGTC_2827 7993847 71.43 µM -1.47818822009861 0.192861305665733 no 2829 0.0696787030181466 4518 2985692 SGTC_1311 1190-0148 100 µM -1.47995139080294 0.192598383922749 no 2830 0.0694431097496328 4521 1961333 SGTC_3154 9100113 49.47 µM -1.48212266573543 0.192274907371937 no 2831 0.06915382943577 4467 25237525 SGTC_1619 st003326 88.7 µM -1.48237082954849 0.192237957097562 no 2832 0.0691208256318852 4465 2849032 SGTC_927 2425-1185 123 µM -1.48521821369813 0.191814307601558 no 2833 0.0687430143596676 4442 730375 SGTC_190 3970-0790 3.722 µM -1.48981499921819 0.191131579957726 no 2834 0.0681364430813652 4455 2832352 SGTC_3236 9132701 49.47 µM -1.48996826882977 0.191108841618133 no 2835 0.0681162897124716 4485 24282524 SGTC_43 0570-0105 72.5 µM -1.49121464860587 0.190923996327891 no 2836 0.067952574477473 4459 1114046 YDL195W SEC31 SGTC_1513 0337-0559 19 µM -1.49313950900254 0.190638744025156 no 2837 0.0677003362061828 4479 775073 SGTC_2593 nobiletin 86.24 µM -1.4961467001579 0.190193620983691 no 2838 0.067307715242367 4463 72344 An anti-infammatory. SGTC_1270 0831-1170 17.3 µM -1.49624116070144 0.190179649329972 no 2839 0.0672954109823269 4507 6764716 SGTC_3216 9129716 49.47 µM -1.49651610210642 0.190138986351317 no 2840 0.0672596075068671 4405 8056934 SGTC_2225 6654152 15.4 µM -1.49845930846865 0.189851744514679 no 2841 0.0670069786101979 4431 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2766 oltipraz 83.91 µM -1.49965269760986 0.1896754718472 no 2842 0.0668521947572361 4469 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_839 0122-0028 230 µM -1.50698886479395 0.18859407708164 no 2843 0.0659067557194423 4514 759448 SGTC_2996 9066192 71.4286 µM -1.5085384067971 0.18836615253124 no 2844 0.0657083923222473 4478 6472854 SGTC_3062 9077494 49.47 µM -1.51538866527411 0.187360574718322 no 2845 0.0648370030709996 4442 16459633 SGTC_2398 5228213 48.84 µM -1.51969702885646 0.186729835379794 no 2846 0.0642935693449695 4449 80771 YMR134W ERG29 SGTC_663 1486-0733 13.9 µM -1.52071540344137 0.186580938825832 no 2847 0.0641656357749889 4519 722445 YPR165W RHO1 SGTC_2512 diallyl trisulfide 49.23 µM -1.52159513378873 0.186452372651104 no 2848 0.0640552788075022 4557 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_3096 9117468 49.47 µM -1.52173049651684 0.186432595247757 no 2849 0.0640383114617891 4465 41316311 SGTC_444 curcumin 90.4 µM -1.52882673262251 0.185397607760674 no 2850 0.0631537016824687 4421 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2964 9083345 53.42 µM -1.52975419982677 0.185262600530136 no 2851 0.0630387910997547 4479 17741579 SGTC_630 4356-0227 183 µM -1.52975628291625 0.185262297372896 no 2852 0.0630385331942353 4465 779312 SGTC_1977 st070720 65.3 µM -1.53041238579315 0.185166828403102 no 2853 0.0629573425471446 4533 682188 SGTC_2121 5257820 149.641 µM -1.53288125339501 0.184807859478313 no 2854 0.0626525578298781 4536 791256 SGTC_266 formosanin C 406 nM -1.53423434769657 0.184611305615796 no 2855 0.062486005237452 4368 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1941 st076221 61.8 µM -1.53550554572089 0.184426766686583 no 2856 0.0623298479515198 4396 2828568 SGTC_316 k060-0003 58.6 µM -1.54007084201478 0.183764972364764 no 2857 0.0617715431324957 4552 6152314 SGTC_1641 st009299 47.1 µM -1.54111715496173 0.18361350541898 no 2858 0.0616441377004818 4453 4046054 SGTC_374 0880-0231 82.3 µM -1.54133168955832 0.183582458454323 no 2859 0.0616180400282356 4385 6833587 SGTC_183 3914-0051 30.55 µM -1.54627380525194 0.182868152552648 no 2860 0.0610192277184872 4507 1596232 SGTC_600 1495-0418 41.6 µM -1.54889792022945 0.182489583604718 no 2861 0.0607031304959495 4493 5377768 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.54973489027943 0.182368940843511 no 2862 0.0606025800920466 4464 6708514 SGTC_268 camptothecin 39.6153 µM -1.55420120471893 0.181725998923349 no 2863 0.0600682151248487 4475 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2048 5246248 200 µM -1.5586017195736 0.181093917875965 no 2864 0.0595453379002767 4528 677046 SGTC_2697 mebhydrolin 72.4 µM -1.56028712179717 0.180852195329071 no 2865 0.0593460226570116 4549 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_3337 9144342 33.5465 µM -1.56328777697188 0.180422338334714 no 2866 0.0589924609877166 4520 17682949 SGTC_849 0386-0493 241 µM -1.56627673397634 0.179994794952827 no 2867 0.0586419226677006 4554 726119 SGTC_1239 0337-0584 35.4 µM -1.5667011141802 0.179934142803193 no 2868 0.0585922851246522 4571 914301 YML130C ERO1 SGTC_598 3937-0236 20.2 µM -1.56725983982104 0.179854309664279 no 2869 0.0585269842045053 4586 1379313 SGTC_2702 st077768 96.8 µM -1.56753202294213 0.179815427021509 no 2870 0.0584951935759293 4492 6484119 SGTC_99 0109-0120 622.8 µM -1.56817808305948 0.179723155429848 no 2871 0.0584197888976739 4537 759414 SGTC_1021 4476-0760 85.3 µM -1.56843852718153 0.179685966696959 no 2872 0.0583894128516992 4545 746768 SGTC_584 0986-0246 15.4 µM -1.56976091064907 0.1794972185929 no 2873 0.0582353723364346 4611 53315 YDR232W HEM1 SGTC_884 0851-0618 334 µM -1.57020756307636 0.17943349460195 no 2874 0.0581834153105534 4548 9642473 SGTC_831 k061-1017 217 µM -1.57080660936623 0.179348050879988 no 2875 0.0581137881932076 4570 1240153 SGTC_809 3998-0021 90 µM -1.57193562089802 0.179187086224963 no 2876 0.0579827412331941 4489 715485 SGTC_1243 0416-0003 5.65 µM -1.57711324601235 0.17845006983274 no 2877 0.0573847349378791 4516 2141977 SGTC_1358 1509-0022 2.48 µM -1.57958838335291 0.178098418530265 no 2878 0.0571005806479804 4561 3258434 SGTC_1711 st032263 62.8 µM -1.58180094743612 0.177784441980429 no 2879 0.0568475093395556 4541 3958979 SGTC_1051 3253-3903 78 µM -1.5845742469476 0.177391387059926 no 2880 0.0565315500055932 4517 5509239 SGTC_1 0258-0098 57.368 µM -1.58775442867449 0.17694134126221 no 2881 0.0561709399942893 4457 6790032 YDR047W HEM12 SGTC_203 k066-0004 30.888 µM -1.59178158997553 0.176372470875914 no 2882 0.0557168940680177 4589 6795412 SGTC_2131 toluylene red 5.2905 µM -1.59921414573574 0.175325602316949 no 2883 0.0548865141253124 4495 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_3244 9134489 49.47 µM -1.59946429862902 0.175290437183658 no 2884 0.0548587376124898 4542 16584271 SGTC_870 0573-2213 57.6 µM -1.60438408709249 0.174599749173314 no 2885 0.0543147082069031 4536 3916321 SGTC_3126 9127922 49.47 µM -1.60438683492551 0.174599363889163 no 2886 0.0543144055490402 4511 45595682 SGTC_1889 st059080 5.18 µM -1.60714986270807 0.174212222444758 no 2887 0.0540107486768711 4518 176925 Isolated from Daphnopsis sellowiana. SGTC_102 gallobenzophenone 83.616 µM -1.61005387785126 0.173805915039016 no 2888 0.0536930473789433 4530 70837 SGTC_1073 triclabendazole 3.09 µM -1.61054688371468 0.173736997354231 no 2889 0.053639259459727 4591 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2212 7123476 200 µM -1.61079481536032 0.173702345361039 no 2890 0.0536122257589702 4601 1085715 SGTC_1444 4112-3581 28 µM -1.61583706450732 0.172998573090956 no 2891 0.053064772807549 4632 2877249 SGTC_1806 st050005 60.3 µM -1.62207103784653 0.172130980981153 no 2892 0.0523940693049653 4594 5194765 SGTC_1316 1272-0050 65.9 µM -1.62601691196167 0.171583264990602 no 2893 0.0519730288603231 4556 7340392 SGTC_88 0180-0332 8.668 µM -1.62623799127219 0.171552610554862 no 2894 0.0519495185812252 4620 3101745 SGTC_2657 nystatin 74.44 µM -1.62858085541454 0.171227968546801 no 2895 0.0517008898907607 4584 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3290 9121031 71.43 µM -1.64100289046888 0.169513261603281 no 2896 0.0503984075945564 4570 17014854 SGTC_1473 k844-0725 134 µM -1.64305159315862 0.169231525792759 no 2897 0.0501861295238362 4599 54682906 SGTC_2866 9034245 58.44 µM -1.64473364288118 0.16900043664344 no 2898 0.0500123758550804 4568 6462273 SGTC_2824 7998404 51.95 µM -1.65244382464585 0.167943765238592 no 2899 0.0492220539346164 4544 837851 SGTC_414 piperonyl butoxide 100 µM -1.65420924079901 0.167702416652067 no 2900 0.0490425029683234 4564 5794 A potent inhibitor of cytochrome P450. SGTC_1985 st071382 65.5 µM -1.65482589563503 0.1676181669393 no 2901 0.0489799097620049 4562 6123237 SGTC_590 k048-0076 22.4 µM -1.66787118759145 0.165842260581004 no 2902 0.0476706501998059 4590 6832814 SGTC_1034 k072-0165 12.7 µM -1.66805666841635 0.165817098366012 no 2903 0.0476522389635621 4588 5835461 SGTC_3121 9125696 49.47 µM -1.67390772349218 0.165024614800435 no 2904 0.0470743680259227 4669 1235365 SGTC_955 1216-0110 33 µM -1.67981621514882 0.16422684453654 no 2905 0.0464965396314436 4557 3619719 SGTC_3054 9094397 49.47 µM -1.68109334358948 0.164054734685968 no 2906 0.0463723925642014 4561 2598354 SGTC_897 1000-0139 31.4 µM -1.68179670069069 0.163959998051585 no 2907 0.0463041343655478 4549 6151020 SGTC_2068 5226020 147 µM -1.68232129153439 0.163889362931885 no 2908 0.046253277309851 4591 1810509 SGTC_97 0535-0701 19.132 µM -1.68330925283687 0.163756389518669 no 2909 0.0461576200636384 4496 2832013 YGL099W LSG1 SGTC_2107 5363541 170.161 µM -1.68402252450052 0.163660431156507 no 2910 0.0460886578686212 4527 244052 SGTC_690 glyoxal 20.3 µM -1.68596671250226 0.163399059701514 no 2911 0.0459011055173297 4380 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2980 9014342 25.29 µM -1.6866453703892 0.163307886621147 no 2912 0.0458357811829716 4601 2996599 SGTC_73 0327-0325 16.231 µM -1.68776114098819 0.16315806226703 no 2913 0.0457285448932436 4402 53298 SGTC_3093 9117344 49.47 µM -1.68825032472305 0.163092403430666 no 2914 0.0456815932613591 4598 24824913 SGTC_170 4197-0004 226 µM -1.6889849095643 0.162993838821182 no 2915 0.0456111609393144 4592 218692 SGTC_2988 9073640 71.4286 µM -1.68942962804325 0.162934186519149 no 2916 0.0455685635769949 4587 9102229 SGTC_1484 3473-2379 286 µM -1.69179893429021 0.16261661896985 no 2917 0.0453421584377184 4686 671917 SGTC_2245 6637752 200 µM -1.69206235775097 0.162581336165202 no 2918 0.0453170423227431 4598 681890 SGTC_967 1306-0166 352 µM -1.69533310537035 0.162143668770303 no 2919 0.0450061240265984 4583 4437607 SGTC_512 prima-1 270 µM -1.69664519096626 0.161968310947014 no 2920 0.0448818802949486 4592 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1426 4048-4480 71.7 µM -1.69841518432826 0.161731950402239 no 2921 0.04471471411307 4602 14224343 SGTC_2083 5306046 65.942 µM -1.7022321430672 0.161223008611861 no 2922 0.044355929739615 4592 539837 SGTC_2649 anisomycin 9.56 µM -1.70252648973015 0.161183804752639 no 2923 0.0443283585326137 4638 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_848 0368-0089 85.6 µM -1.70803391647173 0.160451420823445 no 2924 0.0438150247050074 4595 762535 SGTC_1973 st070275 50.2 µM -1.70885532927421 0.160342375022957 no 2925 0.0437388754121137 4582 17118334 SGTC_2800 7887935 81.82 µM -1.70892246674931 0.160333464398932 no 2926 0.0437326561378712 4566 2961002 SGTC_1743 st037606 46.3785 µM -1.70908384311423 0.160312047519097 no 2927 0.0437177099707922 4549 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_978 1416-0512 87.4 µM -1.71069184970291 0.160098744900097 no 2928 0.0435690065292242 4616 6814003 SGTC_2066 5222451 176 µM -1.71187133723805 0.159942403507163 no 2929 0.0434601909447972 4540 2281147 SGTC_1768 st044301 37.178 µM -1.71256005660196 0.159851159758703 no 2930 0.0433967535134293 4605 3931349 SGTC_1503 4585-0012 61.3 µM -1.71394288877899 0.159668060557517 no 2931 0.0432696076073352 4615 2922052 SGTC_3231 9132313 49.47 µM -1.71790010323011 0.159144849010337 no 2932 0.0429074190037455 4567 4905967 SGTC_2863 9028737 58.44 µM -1.71992736305046 0.158877246069853 no 2933 0.0427228229566454 4591 6460917 SGTC_2966 9084041 48.03 µM -1.72422879526502 0.158310424449458 no 2934 0.0423332738840305 4545 17741380 SGTC_810 3825-7150 143 µM -1.72613178347814 0.158060081873963 no 2935 0.0421618535004709 4603 22330411 YGL099W LSG1 SGTC_2439 5492030 7.2 µM -1.73007483404242 0.15754219183069 no 2936 0.0418084529249845 4604 5722370 SGTC_1374 2889-5571 141 µM -1.73395050207853 0.157034239822309 no 2937 0.0414634330235696 4593 2853281 SGTC_557 1315-0110 16.2 µM -1.73504789395946 0.156890609586036 no 2938 0.0413661611907065 4582 6833801 SGTC_78 0336-0123 156.75 µM -1.73826583016816 0.156469934071517 no 2939 0.0410819921393237 4479 6765896 SGTC_1468 k284-1086 134 µM -1.73891191443579 0.156385562153721 no 2940 0.041025129085699 4605 15996457 SGTC_1016 4226-1401 38 µM -1.73959316176575 0.156296630763369 no 2941 0.0409652404217891 4612 2901613 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.74743562542485 0.155275259365483 no 2942 0.040280901167748 4596 688798 SGTC_2823 7987624 58.44 µM -1.74828584826161 0.155164794995116 no 2943 0.0402072712505359 4543 2239440 SGTC_3269 9137823 49.47 µM -1.74910446242698 0.155058486384413 no 2944 0.0401364820099949 4559 17682936 SGTC_800 3448-7362 155 µM -1.75041847819965 0.154887943458716 no 2945 0.0400230649051665 4670 15991913 SGTC_163 TUB2.036 7.546 µM -1.7522189184504 0.154654469933435 no 2946 0.0398680859007802 4552 15992207 YJR013W GPI14 SGTC_90 0870-0863 4.608 µM -1.7567544708162 0.154067349928224 no 2947 0.0394798342852654 4636 1738164 SGTC_156 3474-0145 5.642 µM -1.75833001525022 0.153863743756665 no 2948 0.0393456867131057 4538 2265471 SGTC_1347 1493-0251 600 nM -1.75969482246329 0.153687514974437 no 2949 0.0392297820774847 4645 3986378 SGTC_1103 duloxetine 36.1 µM -1.76291231794884 0.153272589524883 no 2950 0.0389576395909388 4658 60835 A selective serotonin reuptake inhibitor. SGTC_1555 citronellol 128 µM -1.76379099914023 0.153159404704553 no 2951 0.0388835867328996 4597 8842 A terpine precursor. SGTC_2513 baicalein 25.65 µM -1.76710151491052 0.1527334676298 no 2952 0.0386056144329453 4591 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_364 0083-0097 67.7 µM -1.76813589637313 0.15260054344977 no 2953 0.0385190938340052 4613 5207356 SGTC_469 w7 172 µM -1.76927241732217 0.152454582256087 no 2954 0.0384242120763436 4707 45115570 A P450 inhibitor. SGTC_3217 9129673 49.47 µM -1.77045214714243 0.152303169863475 no 2955 0.0383259246540427 4579 17248312 SGTC_3 0833-0587 95.581 µM -1.77138611003358 0.152183371241989 no 2956 0.0382482583907859 4522 5382644 SGTC_558 k064-0027 21.3 µM -1.77344188731759 0.15191989893462 no 2957 0.0380777566599252 4616 5088526 SGTC_3007 9078383 71.4286 µM -1.77393446794243 0.151856813898943 no 2958 0.0380369952921237 4616 6496995 SGTC_895 0964-0006 13.7 µM -1.77541663874656 0.151667096567692 no 2959 0.0379145593397626 4622 6738897 SGTC_1240 0356-0016 42.1 µM -1.77557493929024 0.151646843469877 no 2960 0.037901501819645 4576 4305613 SGTC_2773 thioridazine 9.09 µM -1.7769825667574 0.15146682955273 no 2961 0.0377855540927613 4605 5452 An antipsychotic. SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.7780324346945 0.151332660121237 no 2962 0.0376992640019037 4624 688662 SGTC_1100 amiodarone 5.07 µM -1.77965294187276 0.151125720207116 no 2963 0.0375663881163758 4636 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_481 bay k-8644 50 µM -1.78066050640875 0.150997148470655 no 2964 0.0374839643415585 4586 2303 A calcium channel antagonist. SGTC_1295 1013-0063 9.78 µM -1.78112962830119 0.150937310334315 no 2965 0.0374456382655787 4625 6826038 SGTC_1163 k060-0048 49.9 µM -1.78149357139677 0.150890898994145 no 2966 0.0374159270829184 4634 6809982 SGTC_1307 1187-1599 12.2 µM -1.78361115238481 0.150621045852028 no 2967 0.0372434360788126 4640 1538471 SGTC_2746 daunorubicin 9.88 µM -1.78698701626895 0.150191508908757 no 2968 0.0369697935455732 4650 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1234 0326-0494 15.5 µM -1.78859685009997 0.149986965240519 no 2969 0.0368398827602827 4672 1547813 SGTC_164 4100-3994 89.624 µM -1.79199024504515 0.149556413004323 no 2970 0.036567264312729 4605 4615967 SGTC_3119 9125183 49.47 µM -1.79472773103689 0.149209683813534 no 2971 0.0363485450098461 4559 22695334 SGTC_2917 7979103 53.79 µM -1.79683605822827 0.148943009900196 no 2972 0.036180825049805 4608 2980565 SGTC_1675 st018485 24.5 µM -1.79767270226464 0.148837274435688 no 2973 0.0361144448661432 4607 3323024 SGTC_1060 3448-7350 82 µM -1.79957285244547 0.148597318940203 no 2974 0.035964055446639 4580 570178 SGTC_3204 9114183 49.47 µM -1.8048948659636 0.147926619728795 no 2975 0.0355455676750875 4568 17027248 SGTC_127 0180-0333 59.125 µM -1.80536681083188 0.147867241520361 no 2976 0.0355086505702216 4549 771601 SGTC_1187 1391-0724 117 µM -1.80685315865434 0.147680339483707 no 2977 0.035392588829087 4661 6997986 SGTC_123 0083-0120 66.675 µM -1.80859562004516 0.147461433781455 no 2978 0.0352569247254053 4606 16001701 SGTC_1630 st005209 31.3 µM -1.80986729607921 0.14730181022087 no 2979 0.0351581844021329 4625 3367314 SGTC_2571 chrysanthemic acid 100 µM -1.81036114315701 0.147239852684665 no 2980 0.0351199004556647 4607 2743 An insecticide. SGTC_1916 st067606 49.2 µM -1.81372160972797 0.146818715970837 no 2981 0.0348602982009843 4533 19590279 SGTC_3238 9133470 49.47 µM -1.81871069042963 0.14619497158747 no 2982 0.0344777899430111 4642 3534688 SGTC_3232 9132874 49.47 µM -1.81912400263585 0.146143378454182 no 2983 0.0344462569441275 4606 3784940 SGTC_2714 st079313 56.9 µM -1.81944475015452 0.146103348459069 no 2984 0.0344218023542573 4628 2939799 SGTC_2421 5690543 90.72 µM -1.82114198574671 0.145891652339216 no 2985 0.034292638232682 4619 3397993 SGTC_791 1348-1292 225 µM -1.82416362037211 0.145515274385311 no 2986 0.0340636698423484 4619 5437054 SGTC_1290 0986-0249 10.2 µM -1.82516650015956 0.14539049909377 no 2987 0.0339879537134512 4525 53329 SGTC_3170 9103054 49.47 µM -1.82868348212294 0.14495349562693 no 2988 0.0337235191789632 4604 16432970 SGTC_439 amiodarone 34.4 µM -1.82933732504695 0.14487234979324 no 2989 0.0336745451995042 4513 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_3136 9095672 49.47 µM -1.83049304266371 0.144728993121224 no 2990 0.0335881230890867 4506 17217380 SGTC_198 3454-2873 16.191 µM -1.83694623968567 0.143930286903524 no 2991 0.0331089160891554 4632 710957 SGTC_2037 5169046 200 µM -1.84000497112507 0.143552751082198 no 2992 0.0328837537463868 4683 5718022 SGTC_2848 9016370 25.97 µM -1.84427759146047 0.143026506236034 no 2993 0.0325713477485696 4615 7894410 SGTC_2375 9072683 200 µM -1.84508970816779 0.142926628055404 no 2994 0.0325122450427603 4662 16798029 SGTC_2926 9010726 65.15 µM -1.84735078980298 0.142648797259798 no 2995 0.0323481581775702 4628 2994293 SGTC_1094 duloxetine 25.4 µM -1.84996515984234 0.142328011581666 no 2996 0.0321592856281126 4651 60834 A selective serotonin reuptake inhibitor. SGTC_3111 9122088 49.47 µM -1.86399071758309 0.140615398520568 no 2997 0.0311615039436645 4611 16876704 SGTC_145 3737-0113 38.366 µM -1.86513532150994 0.140476254761818 no 2998 0.0310812193361135 4622 6849351 SGTC_3215 9129942 49.47 µM -1.86901012096563 0.140005908849428 no 2999 0.0308107031495656 4621 17682944 SGTC_579 4491-1009 110 µM -1.87045559552504 0.139830723030868 no 3000 0.0307102888960043 4681 1271041 SGTC_3100 9120536 49.47 µM -1.87353747579898 0.139457708973237 no 3001 0.0304971013850874 4581 16421196 SGTC_2351 9026858 72.31 µM -1.87525359714241 0.139250292607544 no 3002 0.0303789219090692 4566 1409300 SGTC_2586 curcumin 80 µM -1.87749724222257 0.138979434671197 no 3003 0.0302249874797746 4550 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_3287 9117173 37.0625 µM -1.87918798313695 0.138775561724725 no 3004 0.0301094149373973 4674 2789709 SGTC_370 0180-0345 38.7 µM -1.88088907969445 0.138570645731615 no 3005 0.0299935045130956 4532 3989527 SGTC_2544 sphondin 68.51 µM -1.88359953225536 0.138244567707906 no 3006 0.0298095825915607 4610 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_329 k048-0121 21.3 µM -1.88426362971005 0.138164754042938 no 3007 0.0297646622236342 4664 6832902 SGTC_3166 9102297 49.47 µM -1.89234859936662 0.137195592301025 no 3008 0.0292222748364797 4662 25237072 SGTC_2802 7925815 54.55 µM -1.90262754690516 0.13597015334303 no 3009 0.0285445810285047 4637 1262923 SGTC_1935 st074532 41.6 µM -1.9050836645624 0.135678451768221 no 3010 0.0283845982401063 4626 2829742 SGTC_2881 9058953 51.95 µM -1.90782675860459 0.135353174420912 no 3011 0.0282068055284042 4631 17122249 SGTC_2716 st080858 38.6235 µM -1.91466799959105 0.134544267171292 no 3012 0.0277674285378283 4635 5296050 SGTC_3155 9099265 49.47 µM -1.91569528061159 0.134423088784663 no 3013 0.0277019467515573 4651 25236499 SGTC_743 1275-0778 158 µM -1.91841170158981 0.134103020062514 no 3014 0.0275294142348408 4650 2849257 YMR203W TOM40 SGTC_2570 licareol 100 µM -1.92685337981822 0.133111702822492 no 3015 0.026998952438971 4625 443158 SGTC_2359 9039622 200 µM -1.92959518152193 0.132790817315651 no 3016 0.0268285081624693 4624 6463596 SGTC_2126 5251174 33.877 µM -1.92979036981213 0.132767993872388 no 3017 0.026816408602929 4639 790722 SGTC_2120 5538279 151.968 µM -1.9305233111447 0.132682314874923 no 3018 0.0267710148509192 4673 2058197 SGTC_3043 9092303 49.47 µM -1.93996271122432 0.13158227592053 no 3019 0.0261921108811645 4663 25236084 SGTC_187 1488-2104 32.728 µM -1.9449606172343 0.131002390963877 no 3020 0.0258898592155293 4670 2852859 SGTC_3282 9108498 15.4605 µM -1.94772500252422 0.130682411061011 no 3021 0.0257239383835574 4650 16459645 SGTC_3273 9137859 49.47 µM -1.94943983453303 0.130484189592864 no 3022 0.0256214606553328 4708 2377234 SGTC_1769 st044406 64.4 µM -1.95541174511838 0.129795505829455 no 3023 0.025267245469097 4660 670903 SGTC_647 0140-0236 81 µM -1.9612356568239 0.129126317485176 no 3024 0.0249257695901689 4686 990837 SGTC_291 SEC14.278 35.5 µM -1.97281723273661 0.127802670397094 no 3025 0.0242581945417901 4690 1068044 SGTC_395 anisomycin 6.25 µM -1.97292463220423 0.127790440106267 no 3026 0.0242520748799801 4683 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1000 4048-0884 8.67 µM -1.98743004757912 0.126146081070287 no 3027 0.0234373803284083 4677 13040088 SGTC_480 am 92016 50 µM -1.98973446431647 0.125886212247528 no 3028 0.0233100970288617 4686 2129 K+ channel blocker. SGTC_617 3770-0098 35 µM -1.9905108642203 0.125798741859205 no 3029 0.023267344208817 4628 5962639 SGTC_246 cycloheximide 667 µM -1.99310157732961 0.125507174977368 no 3030 0.0231251626627231 4668 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1481 3346-2004 36 µM -2.00379184478344 0.124309048665651 no 3031 0.0225461813994117 4743 2770522 SGTC_1269 0831-0796 3.05 µM -2.00715706017023 0.123933548400753 no 3032 0.022366471074064 4690 927758 SGTC_3032 9089427 49.47 µM -2.01991565128509 0.122517121876779 no 3033 0.0216960687663905 4662 17173707 SGTC_1315 1237-0019 3.69 µM -2.02399052774122 0.122067141956852 no 3034 0.0214855631859742 4685 825140 SGTC_3195 9113082 49.47 µM -2.0241407578931 0.122050574572936 no 3035 0.0214778355030194 4653 17018038 SGTC_1829 berberine 14.4 µM -2.02475499647582 0.121982852757902 no 3036 0.0214462641444355 4635 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_829 1635-0120 117 µM -2.03445357078213 0.120917050190285 no 3037 0.0209529426436392 4677 285054 SGTC_2030 5175110 200 µM -2.03597287007356 0.120750685771189 no 3038 0.020876539804441 4689 2831986 SGTC_2791 5663188 71.43 µM -2.04103011055833 0.120198075106218 no 3039 0.020623917142351 4663 54690634 SGTC_1680 diphenhydramine 100 µM -2.04649300301141 0.119603143095231 no 3040 0.0203539450887349 4637 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2640 pentamidine 10.38 µM -2.04726546617524 0.119519186505484 no 3041 0.0203160133358292 4654 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_965 1291-5240 308 µM -2.04743399558667 0.119500875100359 no 3042 0.0203077456776908 4687 2834598 SGTC_1208 2323-2347 50.3 µM -2.04766471057465 0.119475810189276 no 3043 0.0202964319658457 4695 5412760 SGTC_3003 9075612 71.4286 µM -2.04978859077721 0.119245245747992 no 3044 0.0201925327238979 4694 6501993 SGTC_3125 9127534 49.47 µM -2.05255910205919 0.118944956519341 no 3045 0.0200576787418067 4646 1639235 SGTC_838 0109-0203 71.4 µM -2.05389956196403 0.118799859060908 no 3046 0.0199927068716592 4707 759422 SGTC_1872 amphotericin b 148 nM -2.05527599310315 0.118650998064178 no 3047 0.0199261773655226 4710 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_431 k089-0097 107 µM -2.05663850821188 0.11850377193482 no 3048 0.0198605055908729 4406 5499420 SGTC_801 0866-0028 10.1 µM -2.05859272434964 0.118292835203544 no 3049 0.0197666351626089 4721 6849771 SGTC_2427 5545055 42.75 µM -2.06279325034808 0.117840332228687 no 3050 0.0195661377997906 4661 5372858 SGTC_2291 7917025 104.35 µM -2.07224529786289 0.116826589829748 no 3051 0.0191212854861808 4627 2964612 SGTC_1121 fusaric acid 630.51 nM -2.07488679566885 0.116544394785766 no 3052 0.0189985138839279 4683 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1318 1280-3875 124 µM -2.07611671539024 0.116413165759272 no 3053 0.0189415787803353 4709 373245 SGTC_1553 gossypol 38.6 µM -2.0783571444079 0.116174387646224 no 3054 0.0188382384023147 4685 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2740 felodipine 17.08 µM -2.08260302805843 0.115722828238996 no 3055 0.0186437114915741 4744 3333 L-type calcium channel blocker SGTC_2775 cyproheptadine 69.59 µM -2.08628717807403 0.115332021807592 no 3056 0.0184763087086991 4698 2913 A selective serotonin reuptake inhibitor. SGTC_565 1418-0001 44.5 µM -2.09562718425982 0.114345460838017 no 3057 0.018057637900516 4725 2862145 SGTC_2737 bleomycin 30.5 nM -2.09765632627705 0.114131924621394 no 3058 0.0179677577559719 4758 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2218 6965428 192.983 µM -2.09841435781455 0.114052226294546 no 3059 0.0179342790233209 4650 675684 SGTC_876 0720-0963 56.8 µM -2.10384371600611 0.113482550298673 no 3060 0.0176960410039686 4707 765861 SGTC_2156 5649887 115 µM -2.10603102087141 0.113253621439734 no 3061 0.0176008289169714 4725 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1495 4469-0029 237 µM -2.1082114759725 0.113025737595239 no 3062 0.0175063505330809 4711 793680 SGTC_1090 efavirenz 20.7 µM -2.11974538601323 0.111825748347052 no 3063 0.017013761626208 4727 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1022 4477-0945 21.3 µM -2.12443137466979 0.111340829746135 no 3064 0.0168170443949223 4671 4648966 SGTC_2451 5856223 45.7 µM -2.12542854399993 0.111237834529289 no 3065 0.0167754353095583 4688 2179896 SGTC_270 tamoxifen 5.46 µM -2.1306107543828 0.110703674837417 no 3066 0.0165606114229408 4708 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2941 9056145 11.23 µM -2.13364295173706 0.110391982847141 no 3067 0.0164360096043652 4684 2119517 SGTC_2666 tannic acid 100 µM -2.13529328298626 0.110222603212647 no 3068 0.0163685306270521 4696 16134267 A thiamine antagonist. SGTC_1712 st032288 53.4 µM -2.13551286983133 0.110200080256373 no 3069 0.0163595700365565 4519 2883011 SGTC_151 3013-0144 2.285 µM -2.13584160113127 0.110166368556719 no 3070 0.0163461634843869 4495 906558 YHR107C CDC12 SGTC_674 0498-0004 451 µM -2.13876757195077 0.109866633450912 no 3071 0.0162272484905343 4699 4231473 SGTC_2061 5245884 80.95 µM -2.14086653765301 0.109651977184891 no 3072 0.0161424011549775 4692 573863 SGTC_654 1124-0271 80.9 µM -2.14312855772627 0.109420983015402 no 3073 0.0160513884587853 4726 5403748 SGTC_202 3594-0513 34.79 µM -2.16467994751214 0.107237699365347 no 3074 0.0152061018820896 4763 708429 SGTC_2504 purpurogallin 52.29 µM -2.16627549792055 0.107077318424719 no 3075 0.0151450704498744 4684 5281571 An antioxidant. SGTC_1713 st033146 12.748 µM -2.17038460672847 0.106665077173953 no 3076 0.0149888609722088 4686 674619 SGTC_1627 st003713 25.6 µM -2.17495868778861 0.106207536804102 no 3077 0.0148166061744213 4701 16195070 YER133W GLC7 SGTC_782 0083-0095 30.5 µM -2.18448298635567 0.105259384352035 no 3078 0.0144633880659369 4717 3591729 An indicator and reagent. SGTC_1803 st050068 52.4 µM -2.18450785510531 0.105256916688353 no 3079 0.0144624753555636 4712 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1280 0880-0253 10.1 µM -2.18644022618223 0.10506530031938 no 3080 0.0143917066615263 4726 6836607 SGTC_712 r015-0009 80.6 µM -2.18775574486741 0.104934996343868 no 3081 0.0143436995457766 4731 6813872 YLR060W FRS1 SGTC_1439 4092-1168 46 µM -2.19615271023186 0.104106021149674 no 3082 0.0140405074360982 4735 2886240 SGTC_157 1348-1695 65.819 µM -2.1966071970544 0.104061288592353 no 3083 0.0140242558912926 4669 5380510 SGTC_2700 st077718 96.8 µM -2.20140371553722 0.103590043953232 no 3084 0.0138537281032977 4700 904970 SGTC_2729 fluphenazine 10.66 µM -2.20294895785885 0.103438558489497 no 3085 0.0137991732018652 4715 3372 An atypical antipsychotic. SGTC_401 neomycin 50 µM -2.20521828332883 0.103216380210266 no 3086 0.0137193904046182 4727 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_324 1315-0088 19.6 µM -2.20800890618644 0.102943639649949 no 3087 0.0136218261638869 4730 6787421 SGTC_625 k213-0058 121 µM -2.21676108519743 0.102091645188714 no 3088 0.0133197110275629 4750 3655420 SGTC_628 1636-0253 16 µM -2.2177357111123 0.101997087112744 no 3089 0.0132864289143288 4736 4456143 SGTC_1983 st071813 46.9 µM -2.22002436231589 0.101775293054841 no 3090 0.0132085569540223 4753 11838595 SGTC_1693 xanthone 101.9 µM -2.22080367971559 0.101699849298832 no 3091 0.0131821306266592 4765 7020 An insecticide. SGTC_219 mitoxanthrone 164.414 µM -2.22303287743153 0.10148427110614 no 3092 0.0131067915539046 4717 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2382 9035899 200 µM -2.2259253997056 0.10120504141298 no 3093 0.0130095893598366 4720 6462679 SGTC_347 4534-1311 26.2 µM -2.22824984281641 0.10098105729552 no 3094 0.0129319295023671 4725 2862016 SGTC_3235 9132602 49.47 µM -2.22927172907346 0.100882702429717 no 3095 0.0128979152443882 4723 4912240 SGTC_42 0133-0086 60.653 µM -2.23138829348591 0.100679208789803 no 3096 0.0128277098099265 4658 162923 Model of phenazepam hydroxylation. SGTC_1683 st010134 710 nM -2.23582217806574 0.100253891000221 no 3097 0.012681710788546 4690 3818134 SGTC_140 0062-0056 502.533 µM -2.24245563232608 0.0996200318166987 no 3098 0.0124659698650689 4659 3758964 SGTC_2002 4023503 131 µM -2.25010968390449 0.0988922943419591 no 3099 0.0122209917556523 4707 4736863 YCR052W RSC6 SGTC_3343 9148379 18.9835 µM -2.25353295542641 0.0985680758553229 no 3100 0.0121127826212002 4744 1955036 SGTC_645 0845-0943 5.41 µM -2.25355270452492 0.0985662076759128 no 3101 0.012112160772418 4737 1885106 SGTC_922 1866-0035 480 µM -2.25503287165408 0.0984262640239155 no 3102 0.0120656327791283 4674 3156169 SGTC_2223 6903751 107.57 µM -2.25571323691433 0.0983619871452521 no 3103 0.0120442980218474 4706 5598863 SGTC_171 k064-0041 9.68 µM -2.25963448193508 0.097992130205684 no 3104 0.0119219728363486 4705 53325 SGTC_1330 1469-0054 61.8 µM -2.26202385783408 0.0977672614282754 no 3105 0.011847964654116 4695 7102664 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -2.26382349526972 0.0975981440024297 no 3106 0.01179248642149 4685 676296 Flavone; oxidizing agent. SGTC_2429 5902844 64.44 µM -2.2670873126141 0.0972919806153333 no 3107 0.0116924462359012 4727 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_3320 9137005 35.139 µM -2.2707496843404 0.0969492703728751 no 3108 0.0115810677217401 4739 4908713 SGTC_2774 tamoxifen 10.92 µM -2.27236854337071 0.0967980667274174 no 3109 0.0115321300053755 4719 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2350 9023895 38.85 µM -2.27685183761966 0.0963802249086524 no 3110 0.0113975373860405 4705 2997209 SGTC_1497 4476-2978 41.3 µM -2.27732989049189 0.0963357488312557 no 3111 0.0113832666438198 4758 1528379 SGTC_880 0833-0487 87.2 µM -2.2803645144535 0.0960537716042832 no 3112 0.0112930392046185 4732 76075 SGTC_957 1187-1561 14.1 µM -2.28064839513538 0.0960274244875902 no 3113 0.0112846305570278 4691 1538454 SGTC_211 3455-0679 143.504 µM -2.2851142607401 0.0956136442569254 no 3114 0.0111530644123097 4691 748649 SGTC_852 0418-0143 439 µM -2.28805859079995 0.0953415589200337 no 3115 0.0110670546470621 4722 5369229 SGTC_1255 0566-0045 221 µM -2.28962823137457 0.0951967416881418 no 3116 0.0110214384997999 4730 2788469 SGTC_2747 doxorubicin 7.63 µM -2.29535249249985 0.0946699858403323 no 3117 0.0108564657997379 4781 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2705 st078069 42.8 µM -2.29653942799426 0.0945610315261317 no 3118 0.010822528732662 4734 1530061 SGTC_143 4032-1194 15.74 µM -2.3032445230342 0.093947275400929 no 3119 0.0106325445304003 4746 1806963 SGTC_566 0958-0068 16.5 µM -2.30380441810097 0.0938961582705693 no 3120 0.0106168125058487 4684 6815365 SGTC_339 3091-4833 71.4 µM -2.30775073492675 0.0935364507470729 no 3121 0.0105065022255093 4571 3240077 SGTC_882 0843-0131 351 µM -2.30971295882374 0.0933579729389539 no 3122 0.0104520254462939 4753 5425421 SGTC_2625 euphol 100 µM -2.31010346896896 0.0933224833819663 no 3123 0.0104412132210059 4712 6708538 A triterpene alcohol. SGTC_118 0083-0097 135.343 µM -2.31329755387309 0.0930325790814589 no 3124 0.010353142547787 4700 5207356 SGTC_1855 st056195 39.6 µM -2.31915155087841 0.0925029824864732 no 3125 0.0101934102034562 4697 4028379 SGTC_582 0987-0078 156 µM -2.3218035848791 0.0922637949994532 no 3126 0.010121757072431 4759 1625765 SGTC_313 3474-0040 5.03 µM -2.32217811412417 0.0922300530524766 no 3127 0.0101116734695165 4742 1043375 YIL048W NEO1 SGTC_1164 k060-0068 93.7 µM -2.32224705100146 0.0922238434128776 no 3128 0.0101098184094205 4744 5963676 SGTC_1462 k081-0014 26.5 µM -2.32712750828795 0.091785011682137 no 3129 0.00997923991126565 4224 3270634 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -2.32731436218784 0.0917682413039047 no 3130 0.00997426996086648 4763 66535 A nucleotide analog. SGTC_2320 7373003 200 µM -2.33282451036077 0.0912747183184057 no 3131 0.00982867885110591 4710 5415828 SGTC_788 1182-0090 188 µM -2.34447529178152 0.0902376863296844 no 3132 0.00952693647449735 4719 5715185 SGTC_847 0342-0274 5.54 µM -2.34471156059807 0.0902167470389185 no 3133 0.00952090209808815 4753 18097 SGTC_2937 9044753 11.33 µM -2.34632355578368 0.0900739804966577 no 3134 0.00947982036457017 4696 6465530 YGL099W LSG1 SGTC_226 1,3-diallylurea 8.28947 mM -2.3463883686214 0.0900682438522816 no 3135 0.00947817185429983 4740 74537 YKL182W FAS1 SGTC_999 SEC7.066 22.7 µM -2.34899031498786 0.0898381673035751 no 3136 0.00941219822124116 4733 740511 YDR170C SEC7 SGTC_855 0428-0020 25 µM -2.35420919560407 0.0893780062255689 no 3137 0.00928108068820276 4749 6812414 SGTC_2844 9010103 25.97 µM -2.35570977961204 0.0892460212751344 no 3138 0.0092436775560197 4688 2480525 SGTC_602 3130-1533 38.1 µM -2.36667709816557 0.0882857830712937 no 3139 0.00897429237437116 4757 720941 SGTC_304 1310-0298 97 µM -2.37042047590124 0.0879598023595485 no 3140 0.0088839328795479 4535 1550234 SGTC_2389 9091542 195.52 µM -2.3748906183351 0.0875717104192668 no 3141 0.00877707564359617 4722 3626624 YOL127W RPL25 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -2.37599313609549 0.0874761879961501 no 3142 0.00875089418789991 4755 5357218 A potent inhibitor of glutathione S-transferases. SGTC_139 0099-0334 718.624 µM -2.37916520246257 0.0872017930948476 no 3143 0.00867594873383961 4733 97690 SGTC_56 0957-0365 83.25 µM -2.39302927917079 0.0860100416792574 no 3144 0.00835495378145601 4708 6752360 SGTC_1177 0983-0204 23.6 µM -2.3965904121896 0.0857059041833836 no 3145 0.00827420515862134 4762 766818 SGTC_3283 9109332 35.8195 µM -2.39961042731297 0.0854486122079738 no 3146 0.00820626430148602 4656 17027281 SGTC_514 4466-0038 2.65 nM -2.4123796337579 0.0843671238272238 no 3147 0.00792438477678356 4613 5722064 SGTC_1353 1498-1206 8.11 µM -2.42578315603982 0.083242995445373 no 3148 0.00763769715514374 4757 6756808 SGTC_1460 k062-0059 9.15 µM -2.43090086089498 0.08281676667079 no 3149 0.00753066752614525 4634 1373085 SGTC_1800 st050079 29.0735 µM -2.43968528862799 0.0820889857931831 no 3150 0.00735003097692795 4645 3645560 SGTC_525 k781-2675 26.7 µM -2.44313748535825 0.081804297354859 no 3151 0.00728009465155467 4725 3651118 YDL195W SEC31 SGTC_1786 berberine 21.6 µM -2.44450719840417 0.0816915491971742 no 3152 0.00725250930864959 4681 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1725 st036284 20.55 µM -2.44487571085275 0.0816612350419272 no 3153 0.00724510340232662 4738 707914 SGTC_2515 chrysin 20.77 µM -2.44573684741751 0.0815904302624507 no 3154 0.0072278233407832 4768 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_695 3505-6186 243 µM -2.45258150474358 0.0810292909256261 no 3155 0.00709176217085284 4741 1819379 SGTC_2898 9056270 58.44 µM -2.45394208804628 0.0809180953252252 no 3156 0.00706498676112402 4770 19154699 SGTC_1694 st024011 44.9 µM -2.4648312392611 0.0800323105496859 no 3157 0.00685388985476744 4776 2787533 SGTC_1689 st020265 53.493 µM -2.46705565411019 0.0798522692835937 no 3158 0.00681145911288053 4767 5758320 YPR016C TIF6 SGTC_2489 cantharidin 73.42 µM -2.47696892864432 0.0790536244768804 no 3159 0.00662517183076513 4741 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_29 0299-0004 12.984 µM -2.47713281068153 0.0790404726374108 no 3160 0.00662213043102344 4716 16871 A napthoquinone isolated from Swertia calycina. SGTC_1877 wortmannin 25 µM -2.48279392825619 0.0785871740277614 no 3161 0.00651782371094724 4768 312145 A covalent inhibitor of PI 3-kinase. SGTC_825 1988-2224 89.6 µM -2.48347270655092 0.0785329552621245 no 3162 0.0065054152250281 4750 1180859 SGTC_2145 5634607 200 µM -2.48641671878067 0.0782981245844402 no 3163 0.00645183838653042 4770 308662 SGTC_197 4544-0043 41.561 µM -2.48685090708102 0.0782635364325877 no 3164 0.00644396989823529 4768 896523 SGTC_3002 9075603 71.4286 µM -2.49551445904401 0.0775758036951592 no 3165 0.00628873146057086 4739 20105405 SGTC_2479 5617353 43.85 µM -2.50162218053649 0.0770937232466533 no 3166 0.00618128884893765 4748 2731746 SGTC_3274 9138298 49.47 µM -2.50677420110146 0.0766888489447371 no 3167 0.00609192580067506 4741 17015756 SGTC_2867 9039098 71.43 µM -2.51939790732572 0.0757036449012896 no 3168 0.00587778627856755 4744 6463460 SGTC_1506 4226-2149 212 µM -2.52466472268858 0.0752954637791771 no 3169 0.0057904358581925 4759 991114 SGTC_2801 7907800 81.82 µM -2.52873533476443 0.0749811401676323 no 3170 0.00572371568720268 4731 6620925 SGTC_1198 1612-1005 86.7 µM -2.52939133742364 0.0749305788774875 no 3171 0.00571302742950784 4767 6998509 SGTC_2264 7948757 110.76 µM -2.53307622734224 0.0746470498535459 no 3172 0.00565331810325846 4736 2971411 SGTC_1920 st075728 45.7 µM -2.53602634716176 0.0744206474886949 no 3173 0.00560591491993635 4742 3400306 SGTC_3095 9117207 49.47 µM -2.54097790589318 0.0740418267350674 no 3174 0.00552714523560008 4774 17015229 SGTC_2029 5175081 200 µM -2.54158599851978 0.0739954061447277 no 3175 0.0055175397746343 4747 1380876 SGTC_217 ketoconazole 989 nM -2.54541535199337 0.0737035916286591 no 3176 0.00545739117095716 4649 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2900 5328528 85.29 µM -2.55517698929933 0.0729636895855746 no 3177 0.0053066908157331 4735 795359 SGTC_2560 caryophyllene 100 µM -2.56450357069806 0.0722620872525856 no 3178 0.00516617581082237 4784 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1971 st069429 63.5 µM -2.56529153728616 0.0722030492758196 no 3179 0.00515445732513834 4767 1246522 YGL099W LSG1 SGTC_928 2764-0428 58.7 µM -2.56610879059921 0.0721418560688771 no 3180 0.00514232829145974 4768 662578 SGTC_2153 5569715 200 µM -2.56717187357692 0.072062315453366 no 3181 0.00512658886399173 4779 2054701 SGTC_1291 0993-0025 5.79 µM -2.57036546952836 0.0718237726950745 no 3182 0.00507956381484081 4754 4353356 SGTC_1559 coumarin 343 70.1 µM -2.57933927800591 0.0711567237480923 no 3183 0.0049494755177825 4772 108770 A hepatotoxic, DNA x-linker. SGTC_344 k064-0035 6.43 µM -2.57991561912766 0.0711140457686719 no 3184 0.00494122296674652 4730 5088750 SGTC_540 1187-0821 17.3 µM -2.5963898766622 0.0699024225174474 no 3185 0.0047104549671329 4743 847520 SGTC_883 0850-0245 24.6 µM -2.59688678048116 0.0698661253529032 no 3186 0.00470364632501259 4772 6823229 YPR165W RHO1 SGTC_2292 7671323 168.05 µM -2.61669504127687 0.0684309798917154 no 3187 0.00443928121921141 4773 937504 SGTC_189 3970-0742 2.116 µM -2.61960635047594 0.0682219810506361 no 3188 0.00440156594526642 4770 2891807 SGTC_3077 9117319 49.47 µM -2.6227052726225 0.0680000553962697 no 3189 0.00436173498297221 4748 17154678 SGTC_3233 9132340 49.47 µM -2.62825036770308 0.0676043415143481 no 3190 0.0042912661045515 4773 17682950 SGTC_2811 7967822 32.47 µM -2.64666749547771 0.0663028029492027 no 3191 0.00406446187911956 4761 2232244 SGTC_2865 9030313 51.95 µM -2.66497572490738 0.0650282777211753 no 3192 0.00384969401822135 4768 42562754 SGTC_3306 9127676 59.7925 µM -2.66896883559154 0.0647528403533664 no 3193 0.00380422547257843 4747 41905287 SGTC_2128 5255449 168.493 µM -2.68073987964342 0.0639461656907922 no 3194 0.00367297966178653 4736 736008 SGTC_2659 sanguinarine 24.21 µM -2.68243251049576 0.063830814447405 no 3195 0.00365444487635962 4766 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1449 4112-4002 201 µM -2.68643095013329 0.0635589671977216 no 3196 0.00361099368732026 4789 2059539 SGTC_871 0574-0004 149 µM -2.69292399109575 0.0631194366347698 no 3197 0.00354142071024233 4751 9551173 SGTC_2338 7999974 200 µM -2.69487803812654 0.0629876266081616 no 3198 0.00352071997900122 4747 315925 SGTC_2263 7948595 193.29 µM -2.69870305720752 0.0627302311113744 no 3199 0.00348051284685512 4785 2971371 SGTC_2641 levomentholum 100 µM -2.70757201473357 0.0621365699561715 no 3200 0.00338886821426278 4785 16666 SGTC_1845 st056753 3.01 µM -2.71151134905252 0.0618742926579351 no 3201 0.00334886241049664 4764 5375839 SGTC_2685 mycophenolic acid 18.85 µM -2.71404251728208 0.061706226269316 no 3202 0.00332338174252789 4791 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1818 st052136 56.3 µM -2.71652549355811 0.0615417062747019 no 3203 0.00329855571202645 4611 674169 SGTC_2693 st077581 40.7 µM -2.7166968781643 0.0615303631202936 no 3204 0.00329684829196195 4749 25238761 SGTC_2309 7664088 163.95 µM -2.71769236695176 0.0614645086054052 no 3205 0.00328694643529031 4758 704922 SGTC_3114 9122766 49.47 µM -2.71841038032798 0.06141704408888 no 3206 0.00327982116138797 4784 17176985 SGTC_1036 k216-0215 33.5 µM -2.71943213419425 0.0613495500715255 no 3207 0.00326970563762927 4756 622330 SGTC_2192 5915882 198.485 µM -2.72003607434851 0.0613096828397723 no 3208 0.00326373973791902 4788 2876149 SGTC_2412 st077135 33.4 µM -2.72697751515155 0.0608529171713456 no 3209 0.00319586972095018 4757 13258915 SGTC_3149 9097855 49.47 µM -2.72971197006523 0.0606737148562096 no 3210 0.00316948412240051 4754 25236625 YMR079W SEC14 SGTC_2177 5811945 192 µM -2.73727919368994 0.0601799487401836 no 3211 0.00309748460765162 4758 5343475 SGTC_245 methotrexate 289.6 µM -2.74596742655236 0.0596169215132136 no 3212 0.0030166376771659 4755 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_403 arphamenine a 50 µM -2.7492321663402 0.0594064253170708 no 3213 0.00298675295469256 4789 5487158 An arginine aminopeptidase inhibitor. SGTC_2997 9067075 71.4286 µM -2.76420863126015 0.0584482660599182 no 3214 0.00285305212286796 4764 27209819 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -2.76614417095817 0.0583253253499232 no 3215 0.00283617255784766 4769 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1827 berberine 7.24 µM -2.77357303730877 0.0578553470415409 no 3216 0.00277221964891713 4733 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_998 3996-0085 177 µM -2.77488315513371 0.0577727736712875 no 3217 0.00276107718334986 4771 715391 SGTC_2044 5102272 200 µM -2.77623288078635 0.0576878008539512 no 3218 0.0027496401406116 4784 592666 SGTC_1958 st076513 41.9 µM -2.79456448778254 0.056543429717072 no 3219 0.00259848372176364 4755 732122 YGL099W LSG1 SGTC_1930 st074634 34.3 µM -2.79730508658596 0.0563738924829062 no 3220 0.00257654244492302 4737 684253 YOR116C RPO31 SGTC_2730 imipramine 71.33 µM -2.80621619510219 0.0558254072302994 no 3221 0.0025063523845066 4766 3696 A tricyclic antidepressant. SGTC_3026 9090633 49.47 µM -2.85016056481766 0.0531819254645568 no 3222 0.00218485818284075 4788 25236842 SGTC_1707 st032323 6.317 µM -2.86229940173347 0.0524694797157979 no 3223 0.00210289699556474 4673 3132057 YMR211W DML1 SGTC_1017 4239-0030 168 µM -2.87136679353348 0.051942261338413 no 3224 0.00204350496038294 4775 1149593 SGTC_1385 3091-4834 14.1 µM -2.88118462146507 0.0513761647641389 no 3225 0.00198091750327705 4775 4072814 SGTC_348 k064-0012 10.7 µM -2.88473985558825 0.0511723841417101 no 3226 0.00195868609935166 4782 5066323 SGTC_952 1185-0122 232 µM -2.88664348929773 0.0510635354275493 no 3227 0.00194687577402765 4753 678600 SGTC_2630 antimycin a 100 µM -2.89135012905693 0.0507952033347624 no 3228 0.00191795250374194 4756 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2411 st077133 39.94 µM -2.89149681125385 0.0507868588536034 no 3229 0.00191705741735868 4760 1403142 YNL221C POP1 SGTC_920 mycophenolic acid 780.421 nM -2.89495838297079 0.0505902530284719 no 3230 0.00189604402006227 4769 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1275 0867-0008 21.1 µM -2.89553308082821 0.0505576708502884 no 3231 0.00189257565929254 4788 3422836 SGTC_2347 9049783 174.81 µM -2.90374640761002 0.0500938450200989 no 3232 0.0018436334452549 4779 6467988 YPL169C MEX67 SGTC_1146 3579-1023 7 µM -2.90408592996013 0.0500747446619316 no 3233 0.00184163526534316 4788 X1146 SGTC_2195 6536160 144.242 µM -2.90877821086148 0.0498113673160465 no 3234 0.00181422085815159 4795 3834386 SGTC_377 3970-0964 33.1 µM -2.91379966170484 0.0495307389545448 no 3235 0.00178529482851814 4781 16481235 SGTC_2575 plumbagin 510 nM -2.93999793899887 0.0480870304251611 no 3236 0.00164107214996076 4754 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_885 0865-0106 16.8 µM -2.96206236872236 0.046897424214611 no 3237 0.00152792938617319 4778 2793380 SGTC_3071 9117417 49.47 µM -2.98235351563956 0.0458243686411078 no 3238 0.00143020747654856 4772 45595590 YGL055W OLE1 SGTC_953 1188-0045 9.7 µM -2.98378628657665 0.0457493514885266 no 3239 0.00142352776575985 4770 6144426 SGTC_3076 9116187 49.47 µM -2.98483574965643 0.0456944662577686 no 3240 0.00141865315789634 4785 27241210 SGTC_488 nitrendipine 139 µM -2.98506953524972 0.0456822468589333 no 3241 0.00141756933471455 4789 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2475 5812728 15.03 µM -2.9889990000723 0.0454772562246138 no 3242 0.00139946523848339 4770 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2755 lomerizine 42.69 µM -3.01573752821142 0.0441019422412818 no 3243 0.00128177531543307 4776 3949 A calcium channel blocker. SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -3.02164863201432 0.0438024728086741 no 3244 0.00125701091431204 4803 165521 SGTC_2902 5787006 60.46 µM -3.03884574191514 0.0429405491587886 no 3245 0.00118743211567942 4782 591003 SGTC_2337 9009472 200 µM -3.0413175999181 0.0428177932147795 no 3246 0.00117772615056293 4762 5742383 SGTC_2748 diazoxide 86.69 µM -3.04170499596357 0.0427985803165464 no 3247 0.00117621160781979 4808 3019 A potassium channel activatior. SGTC_1044 1222-0021 1.78 µM -3.05734177358735 0.042028873806438 no 3248 0.00111654750535135 4761 4306703 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -3.06968935423343 0.0414290252671321 no 3249 0.00107140761456774 4772 279621 SGTC_2671 danthron 100 µM -3.0788397977525 0.0409889854635278 no 3250 0.00103904197871818 4790 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1754 st042065 16.137 µM -3.08769631381871 0.0405666981423933 no 3251 0.0010085724519494 4700 1126236 YIL048W NEO1 SGTC_25 0118-0223 35.662 µM -3.09331818294733 0.0403004791223437 no 3252 0.000989658976128203 4790 5333628 SGTC_607 4491-0986 66.8 µM -3.09927170757824 0.0400201035435519 no 3253 0.000969985100359105 4797 698981 YDR232W HEM1 SGTC_61 0978-8327 98.565 µM -3.1033070833296 0.0398309642101849 no 3254 0.000956854780402365 4774 6150059 YHR072W ERG7 SGTC_896 0964-0007 44.5 µM -3.11694125694807 0.0391972948640111 no 3255 0.000913689902644006 4779 6756758 SGTC_2130 NSC 7 2.4545 µM -3.12327787944095 0.0389055960640605 no 3256 0.000894244019236114 4789 21448 SGTC_22 0964-0034 14.468 µM -3.1247165997359 0.0388396131623957 no 3257 0.00088988218720742 4794 138402 SGTC_1539 benzyladenosine 56 µM -3.12502754954725 0.0388253642997277 no 3258 0.000888942040851899 4801 92208 A nucleotide analog. SGTC_2626 ethyl orsellinate 100 µM -3.14102816858793 0.0380978843490679 no 3259 0.000841779195183088 4774 75653 A natural product. SGTC_2326 6164455 177.58 µM -3.1465411559489 0.0378498225349718 no 3260 0.000826070040533805 4773 2888790 SGTC_1182 1222-0449 220 µM -3.14952760468189 0.0377159959663679 no 3261 0.000817673289965353 4795 658318 SGTC_576 1073-0113 22.7 µM -3.16267145153505 0.0371315868923361 no 3262 0.000781643256190466 4799 5439563 SGTC_3118 9124250 49.47 µM -3.18255151656132 0.0362617483079388 no 3263 0.000729917715311468 4796 1504786 SGTC_877 0771-0151 33.1 µM -3.21957843572505 0.0346861465787188 no 3264 0.000641896173680094 4801 6166523 SGTC_62 0180-0423 3.232 µM -3.22481578033758 0.0344678903220058 no 3265 0.000630268766675677 4789 30102 YGL099W LSG1 SGTC_2781 5567276 71.43 µM -3.24439584654934 0.0336619013494952 no 3266 0.000588500264015112 4776 2853274 SGTC_520 3584-0023 682 µM -3.24482989090665 0.0336442116983401 no 3267 0.000587604024922982 4785 1340790 SGTC_2459 5811157 9.22 µM -3.2470080580629 0.0335555551187618 no 3268 0.000583125438770821 4793 2870684 YBR192W RIM2 SGTC_221 trifluoperazine 10.304 µM -3.25519026466201 0.0332242362240874 no 3269 0.000566582118168205 4774 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1763 st044482 94.5 µM -3.25735639691804 0.0331369764054203 no 3270 0.000562275711539142 4794 88505 SGTC_2584 androsterone 48.74 µM -3.26275877009998 0.0329201712298235 no 3271 0.000551666962250222 4754 2754130 A steroid. SGTC_2065 5221596 34.26 µM -3.26962487522543 0.0326463128918398 no 3272 0.000538450962057895 4792 788581 SGTC_3030 9087619 49.47 µM -3.26971689023631 0.0326426556198019 no 3273 0.000538275855509969 4791 25236973 SGTC_3299 9121982 43.1275 µM -3.27030648159315 0.0326192294614183 no 3274 0.00053715509993811 4792 17594604 YPL160W CDC60 SGTC_350 k064-0020 19.8 µM -3.27799069168477 0.032315179679255 no 3275 0.000522744215828034 4791 2790705 SGTC_2196 6573537 42.6665 µM -3.28299956431084 0.032118249974938 no 3276 0.000513544122090397 4797 2903087 SGTC_1406 3909-7906 11.9 µM -3.31035922628515 0.0310599846018894 no 3277 0.000465881536678067 4801 X1406 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -3.33499022232779 0.0301320991683058 no 3278 0.000426511992941657 4801 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1425 4048-4433 7.33 µM -3.35708804064437 0.0293193116002625 no 3279 0.000393840133707527 4804 23734946 SGTC_3339 9145883 14.936 µM -3.35869546159343 0.0292609057487933 no 3280 0.000391556585772121 4788 2030670 SGTC_2471 5466956 24.79 µM -3.36732636590989 0.0289489508281727 no 3281 0.000379504028853582 4803 724419 SGTC_1830 st055982 50.3 µM -3.39759901350048 0.0278765499437394 no 3282 0.000339899913143024 4798 455313 An antimicrobial agent. SGTC_3042 9091578 49.47 µM -3.39906469832003 0.0278254797501236 no 3283 0.000338083596595308 4776 25236497 SGTC_1001 4048-4355 44.4 µM -3.40558992331951 0.0275990604642023 no 3284 0.000330106333527796 4797 21824233 SGTC_2289 7946404 165.07 µM -3.40959703616638 0.0274607799798994 no 3285 0.00032529464447212 4792 1246120 YPR165W RHO1 SGTC_1450 4112-4260 37.6 µM -3.45431113375694 0.0259565690099372 no 3286 0.000275850244517426 4791 1633175 SGTC_322 k048-0136 19.3 µM -3.46899418956978 0.0254779101647847 no 3287 0.00026120537615635 4807 6823282 SGTC_1081 sertraline 6 µM -3.48110192410267 0.0250887868711827 no 3288 0.000249677716142675 4801 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2274 7947094 46.08 µM -3.49492442719605 0.0246506557782847 no 3289 0.000237098001056414 4795 2971028 SGTC_72 0744-0168 198.391 µM -3.49889213447052 0.024526083887334 no 3290 0.000233597770765174 4781 677577 SGTC_2282 7944268 200 µM -3.49940832911015 0.0245099161195449 no 3291 0.000233145954953164 4796 2970414 SGTC_2511 berberine 10.47 µM -3.50627103119138 0.0242958176291942 no 3292 0.000227216115124074 4792 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1741 st038134 10.228 µM -3.5123569200566 0.0241072696673948 no 3293 0.000222075541317054 4792 1272587 SGTC_1265 0819-1001 68.8 µM -3.5360417247975 0.0233851471887422 no 3294 0.000203085268107797 4786 3106768 SGTC_2555 cholic acid 100 µM -3.56028029123661 0.0226650739673994 no 3295 0.000185229579005866 4791 6708657 Influences liver metabolism. SGTC_2968 9090663 33.37 µM -3.56060118620733 0.0226556676850255 no 3296 0.00018500334688753 4787 25236811 SGTC_1504 k297-0033 30 µM -3.56258421782836 0.0225976127402458 no 3297 0.000183611023061781 4793 4388117 SGTC_619 1652-1634 108 µM -3.62254503747356 0.0209005276703724 no 3298 0.000145859324728701 4798 5400454 SGTC_3355 9151058 44.0485 µM -3.64600332309312 0.0202665902651702 no 3299 0.000133175265949784 4805 17015728 SGTC_393 acivicin 6.25 µM -3.66616761251538 0.0197347710962049 no 3300 0.000123106290443462 4785 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2266 7929956 200 µM -3.66796860964573 0.0196878526896402 no 3301 0.000122242595256062 4796 2967153 SGTC_1962 st076595 64.5 µM -3.68336945518189 0.0192904936809826 no 3302 0.00011508559184959 4797 279619 SGTC_2046 4110841 106 µM -3.68917499344297 0.0191424834627297 no 3303 0.000112491217723168 4806 44119630 YMR134W ERG29 SGTC_2241 6772625 37.8075 µM -3.69288187820758 0.0190484836255713 no 3304 0.000110863513851361 4746 2285411 SGTC_3321 9137793 26.8275 µM -3.70166221865903 0.0188273950436458 no 3305 0.000107095822927636 4806 4904192 SGTC_55 0767-0285 6.563 µM -3.72271372095274 0.0183061955317061 no 3306 9.85464761042413e-05 4801 3116166 SGTC_2442 5158906 48.48 µM -3.74764841599897 0.0177048051357407 no 3307 8.92501095089711e-05 4803 1893835 SGTC_1476 4112-3294 3.34 µM -3.76878177196603 0.0172083758280225 no 3308 8.2023114981881e-05 4803 704369 SGTC_2754 granisetron 64.02 µM -3.77146066649891 0.0171463052471162 no 3309 8.11473715222104e-05 4803 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2485 5633444 17.78 µM -3.78213604929994 0.0169008510494181 no 3310 7.77441679010157e-05 4802 5724239 SGTC_3075 9116269 49.47 µM -3.79571435915114 0.0165929976679266 no 3311 7.36094632529044e-05 4801 17015205 YNL244C SUI1 SGTC_2507 purpurin 79.67 µM -3.80777916312211 0.016323498061866 no 3312 7.01102030660232e-05 4805 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2305 7443522 69.23 µM -3.81299547216834 0.0162081437663547 no 3313 6.86463143629477e-05 4792 5415886 SGTC_491 tetrandrine 80.3 µM -3.82769390822934 0.015886849557081 no 3314 6.46747365751514e-05 4807 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1401 3807-4679 7.6 µM -3.83942837071548 0.0156342799758498 no 3315 6.16605504754247e-05 4784 3291456 SGTC_2686 alizarin 95.37 µM -3.84007774314666 0.0156204042250308 no 3316 6.1497677334026e-05 4801 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_3314 9135860 59.4275 µM -3.8613982737066 0.0151706610304884 no 3317 5.63699758019812e-05 4804 25252478 SGTC_3144 9087057 49.47 µM -3.86547550199181 0.0150859335838427 no 3318 5.54364890292966e-05 4794 17249618 SGTC_3302 9125395 16.351 µM -3.86665519718285 0.0150614947298248 no 3319 5.51691284364477e-05 4796 17599668 SGTC_1392 3455-1037 33.9 µM -3.89565430696043 0.0144713505507634 no 3320 4.89669941250067e-05 4806 981132 SGTC_2972 9093619 59.92 µM -3.90892052694558 0.0142080825894613 no 3321 4.63547269671392e-05 4796 25236256 SGTC_2011 4012611 177 µM -3.9165142846 0.0140592494483753 no 3322 4.49192474860646e-05 4797 2049887 SGTC_1755 st041960 45.185 µM -3.92523916411314 0.0138899076091354 no 3323 4.33218050875722e-05 4802 2257073 SGTC_3349 9149703 23.001 µM -3.94545917082452 0.0135042036972671 no 3324 3.98236016618878e-05 4804 4910494 SGTC_2760 etidronate 98.04 µM -4.04956491805256 0.0116613803639358 no 3325 2.56564712227287e-05 4801 3305 A chelator and antioxidant. SGTC_1145 3546-0597 10.2 µM -4.08232131025686 0.0111286167629796 no 3326 2.22940462728958e-05 4805 875334 SGTC_3139 9095020 49.47 µM -4.1209832831741 0.0105271459228091 no 3327 1.88629401004432e-05 4804 25236292 SGTC_2307 7538926 6.34 µM -4.15094875416001 0.0100806470283335 no 3328 1.65549950577904e-05 4802 96582 SGTC_2897 9048598 12.99 µM -4.31747341475564 0.00788828960904235 no 3329 7.89127055033856e-06 4807 6467404 SGTC_3142 9086498 49.47 µM -4.35462331933712 0.00746072075235341 no 3330 6.66479627928955e-06 4787 25236367 SGTC_1547 harmine 94.2 µM -4.3899509094733 0.00707320235125207 no 3331 5.66881263293257e-06 4796 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2967 9089538 49.85 µM -4.39469648803222 0.00702252376176759 no 3332 5.54638148588065e-06 4800 728216 SGTC_1728 st035614 33.7865 µM -4.40300179285917 0.00693460130059686 no 3333 5.33816416850252e-06 4799 15945546 SGTC_1718 roemerine 11.9335 µM -4.43216140655747 0.00663355707922739 no 3334 4.66465680204005e-06 4707 235224 An aporphine alkaloid with mutagenic activity. SGTC_135 0933-0004 26.348 µM -4.47666990370889 0.0061963119442077 no 3335 3.79081677173338e-06 4806 21230617 YGL099W LSG1 SGTC_3190 9110366 49.47 µM -4.5030310325556 0.00594955602814927 no 3336 3.34955486303474e-06 4807 17123768 SGTC_2978 9011784 42.97 µM -4.50563851397205 0.00592562848968935 no 3337 3.30868281549225e-06 4801 2994934 SGTC_1348 1493-0373 93.8 µM -4.58116081577385 0.00526862239220505 no 3338 2.31201043884453e-06 4806 3010129 SGTC_299 1273-0059 1.44 µM -4.59009060677274 0.00519538853947348 no 3339 2.21526821298832e-06 4759 2848077 SGTC_1679 SEC14.276 6.7 µM -4.62401500806398 0.00492536097393121 no 3340 1.88191307825331e-06 4808 1005053 YMR079W SEC14 SGTC_1859 st055998 20 µM -4.62843869630743 0.00489108760049037 no 3341 1.84216446282997e-06 4804 676301 SGTC_3347 9188721 44.724 µM -4.64441190232742 0.00476909461814319 no 3342 1.70523268549478e-06 4809 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_310 1273-0058 1.06 µM -4.66499473384037 0.00461590060058064 no 3343 1.54312471264594e-06 4684 2734232 SGTC_1731 st035964 63 µM -4.69184143820649 0.00442269184378567 no 3344 1.35378470579942e-06 4803 6739575 SGTC_2797 7859098 81.82 µM -4.70862704190959 0.00430559246556927 no 3345 1.24695454734519e-06 4805 972681 SGTC_2810 7959871 45.46 µM -4.80440200727985 0.00368894576729294 no 3346 7.76073475028722e-07 4806 2974535 SGTC_2089 5281248 129.67 µM -4.80987186652938 0.00365624751348871 no 3347 7.55135390946372e-07 4810 2737878 SGTC_2526 patulin 37.61 µM -4.83376098155199 0.00351646818443585 no 3348 6.69887179865528e-07 4809 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_138 0850-0259 40.9225 µM -5.00678663504439 0.00263920684929251 no 3349 2.76731094466651e-07 4803 6813004 SGTC_2085 5307070 144.047 µM -5.17798164486342 0.00197086384935489 no 3350 1.12149646467798e-07 4810 2840351 SGTC_3194 9111903 49.47 µM -5.17857295997056 0.00196884959777166 no 3351 1.11794814785735e-07 4809 17087251 SGTC_951 1171-0579 82.7 µM -5.32961778583211 0.00151150405916192 no 3352 4.92098367938486e-08 4796 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2890 9046729 58.44 µM -5.66337826099022 0.00082421691645687 yes 3353 7.42107405516187e-09 4810 903329 SGTC_2883 9059145 45.46 µM -5.75530405417524 0.000693668865827967 yes 3354 4.32429935104914e-09 4803 16476510 SGTC_2481 5478948 45.16 µM -5.82774955364731 0.000604526528300748 yes 3355 2.80899016469203e-09 4809 77792 SGTC_58 0957-0393 9 µM -7.38950939161441 2.1804894282597e-05 yes 3356 7.36857793033967e-14 4765 6997992