SGTCid condition conc unit DOA4|YDR069C.score DOA4|YDR069C.strain.pval DOA4|YDR069C.strain.significant DOA4|YDR069C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_168 3970-0862 530.542 µM 12.6212018311007 1.58644373189146e-32 yes 1 8.06700206523189e-37 5 3135186 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 8.99108313185936 2.04969650379159e-17 yes 2 1.22402897454721e-19 8 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1844 rapamycin 4 nM 8.03954406040057 2.80533107138892e-14 yes 3 4.5086679575607e-16 57 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_150 3970-0969 77.2 µM 7.89512328733517 7.83745542633731e-14 yes 4 1.45014199848082e-15 8 6615640 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 7.61070337736087 5.62279796343975e-13 yes 5 1.36304113880867e-14 9 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_159 3970-0959 50 µM 7.4996103821813 1.19112038187168e-12 yes 6 3.20039009029527e-14 15 6615653 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 7.34595529761573 3.30534665998089e-12 yes 7 1.02147325440726e-13 22 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2679 rapamycin 1 nM 6.9750364503813 3.57049108528156e-11 yes 8 1.5289576124879e-12 61 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2766 oltipraz 83.91 µM 6.8389355517572 8.29888245615105e-11 yes 9 3.98918828431812e-12 7 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_149 3970-0822 46.1 µM 6.77530003394038 1.22434446155895e-10 yes 10 6.20741729219937e-12 25 3114250 YBL034C STU1 SGTC_214 4373-3496 70 µM 6.6318583907149 2.904219249506e-10 yes 11 1.65743264714963e-11 12 3779166 SGTC_2200 6600604 21.907 µM 6.55713459157419 4.5226921368576e-10 yes 12 2.74257522852327e-11 22 2904777 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 6.46367604750963 7.81731444523656e-10 yes 13 5.10947606732474e-11 10 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1428 4049-0204 61.7 µM 6.42157287458136 9.97832708763744e-10 yes 14 6.74367089968352e-11 1 X1428 SGTC_2582 agaric acid 100 µM 6.09521729797346 6.2843579676839e-09 yes 15 5.46444460674803e-10 155 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1228 0124-0032 52.5 µM 5.80252376313014 3.02881990746455e-08 yes 16 3.26620662581372e-09 3 X1228 SGTC_1365 1672-3266 55.4 µM 5.63074812647825 7.3669254260007e-08 yes 17 8.97148002375187e-09 2 6415873 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 5.50601549074031 1.38267649445016e-07 yes 18 1.83523123249658e-08 21 91467 include heat shock SGTC_488 nitrendipine 139 µM 5.488946795523 1.50552924530632e-07 yes 19 2.02168690917527e-08 21 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1193 1488-0126 41.5 µM 5.38427558618986 2.52367265713991e-07 yes 20 3.63684946384944e-08 9 1384710 SGTC_268 camptothecin 39.6153 µM 5.273740582601 4.31063729082962e-07 yes 21 6.68354113601092e-08 42 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3307 9126885 69.2785 µM 5.22159174850967 5.52925605356301e-07 yes 22 8.86958516178293e-08 13 24824909 SGTC_207 4185-0010 4.486 µM 5.20157315245764 6.08003664987801e-07 yes 23 9.88043310947591e-08 53 3761753 SGTC_3214 9129694 49.47 µM 5.12658002866885 8.65128025395219e-07 yes 24 1.47526335252489e-07 8 17158655 SGTC_58 0957-0393 9 µM 5.09138507775604 1.0191789644398e-06 yes 25 1.7772864553218e-07 276 6997992 SGTC_98 0074-0023 107.663 µM 4.83893976908583 3.2014800397507e-06 yes 26 6.5266797141256e-07 22 3563821 SGTC_486 niguldipine 82 µM 4.79209792935357 3.93557494081882e-06 yes 27 8.25231509793209e-07 10 1236 A calcium channel blocker. SGTC_79 0052-0007 94.094 µM 4.76767325139314 4.37963719760859e-06 yes 28 9.31828565289976e-07 23 2801472 SGTC_273 hydroxyurea 18.1 mM 4.69125617378111 6.09939991784188e-06 yes 29 1.35766366046191e-06 18 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_513 4245-1575 41.7 µM 4.48871726501732 1.43280218890159e-05 yes 30 3.58266608635079e-06 91 719745 SGTC_1112 tnp00069 1.16933 µM 4.37275382116193 2.30028991602105e-05 yes 31 6.13445227988672e-06 16 145826 SGTC_2211 7117706 200 µM 4.3166539779758 2.88058517593222e-05 yes 32 7.92060947175231e-06 6 822771 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 4.23519137048441 3.97469496819639e-05 yes 33 1.14178572748313e-05 34 368090 SGTC_177 1327-0068 8.361 µM 4.23179680429608 4.02789144705605e-05 yes 34 1.15915903427699e-05 39 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1085 doxorubicin 7.67 µM 3.99614364072588 9.90059307355627e-05 yes 35 3.21913390317954e-05 16 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_212 3807-4682 38.772 µM 3.98933122818497 0.000101543568155645 yes 36 3.31299218801102e-05 68 3125501 YBL034C STU1 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 3.97917928747784 0.000105438792913788 yes 37 3.45767888793362e-05 41 6728940 SGTC_1484 3473-2379 286 µM 3.92591375847723 0.000128281321479813 yes 38 4.32005552354241e-05 14 671917 SGTC_489 paxilline 115 µM 3.90244051089178 0.000139754913959256 yes 39 4.76138236115909e-05 15 105008 A toxic potassium channel blocker. SGTC_2769 toremifene 3.73 µM 3.89013864614035 0.000146145391041825 yes 40 5.0093481943736e-05 25 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2090 5301565 104.445 µM 3.86717457245731 0.000158813173559239 yes 41 5.50518057393087e-05 49 2056344 SGTC_1846 st056244 14.8 µM 3.82476182258703 0.000184953008042076 yes 42 6.54492856839128e-05 31 5393182 SGTC_2167 5876490 200 µM 3.76514690975737 0.000228547879249825 yes 43 8.32255937155737e-05 37 686534 SGTC_1405 3909-7894 12 µM 3.71648461423022 0.000271053554161578 yes 44 0.000101006968406301 17 7104060 SGTC_2187 6125751 200 µM 3.71497049138629 0.000272487343582962 yes 45 0.000101613704493999 22 874498 SGTC_163 TUB2.036 7.546 µM 3.69988348225563 0.00028716495577622 yes 46 0.000107849238586699 120 15992207 YJR013W GPI14 SGTC_1073 triclabendazole 3.09 µM 3.67931707481876 0.000308361168042897 yes 47 0.00011692968136778 34 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2170 morpholine 200 µM 3.64270882695063 0.000349731823553675 yes 48 0.000134891976415262 17 121171 Reacts with secondary amines. SGTC_724 3910-0327 137 µM 3.62707579442237 0.000368923716744113 yes 49 0.000143324585216206 26 2885483 SGTC_1824 st053723 68.6 µM 3.60853712761577 0.000392949194951308 yes 50 0.000153964225753606 42 675225 SGTC_679 0422-0091 41.4 µM 3.58466708078957 0.000426023892372942 yes 51 0.000168754223654497 44 627384 YHR062C RPP1 SGTC_2817 7995342 71.43 µM 3.56491903988917 0.000455319160597801 yes 52 0.000181984259899841 35 18879975 SGTC_1655 st012546 55.1 µM 3.52089519377361 0.000527470079098238 yes 53 0.000215046286448917 40 720985 YLR208W SEC13 SGTC_2293 7624732 200 µM 3.5174772545397 0.000533492628333358 yes 54 0.000217834843437202 39 894453 SGTC_3119 9125183 49.47 µM 3.49456667052372 0.000575533006369524 yes 55 0.000237415999551086 14 22695334 SGTC_43 0570-0105 72.5 µM 3.46431054359568 0.000635748729642694 yes 56 0.00026579622234407 137 1114046 YDL195W SEC31 SGTC_66 0109-0187 42.4 µM 3.4631315923319 0.000638208781998095 yes 57 0.000266963601090981 55 759417 SGTC_155 k072-0202 43.6 µM 3.45989156894179 0.00064501489119759 yes 58 0.00027019647302843 28 5857737 SGTC_1164 k060-0068 93.7 µM 3.4252411612256 0.000722110877057796 yes 59 0.000307126959937486 47 5963676 SGTC_3200 9114385 49.47 µM 3.40934350555078 0.000760251088922754 yes 60 0.000325597137309058 58 17018030 YLR208W SEC13 SGTC_2460 5552655 174.22 µM 3.38728215998751 0.000816257253329496 yes 61 0.000352943748085802 48 5401989 SGTC_172 1112-0046 2.638 µM 3.37003959592488 0.00086264702977407 yes 62 0.000375786916121966 53 2802135 YIL048W NEO1 SGTC_89 0302-0250 142.109 µM 3.36545876422513 0.000875372641953077 yes 63 0.000382082441309977 41 4203518 YLR208W SEC13 SGTC_1694 st024011 44.9 µM 3.36266935723808 0.000883205970187279 yes 64 0.000385963801326583 61 2787533 SGTC_2774 tamoxifen 10.92 µM 3.33340889903098 0.000969348843226139 yes 65 0.000428943804485193 30 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_879 0831-1030 162 µM 3.31339420365797 0.00103264456964973 no 66 0.000460854851014481 80 1549252 SGTC_1717 st033143 58.0435 µM 3.2929748376012 0.00110110783239202 no 67 0.000495666730676697 76 674616 SGTC_695 3505-6186 243 µM 3.26626079670221 0.00119695755073873 no 68 0.000544889169826209 48 1819379 SGTC_1396 3511-0007 98.6 µM 3.22809534379338 0.00134717972015625 no 69 0.000623087157072523 31 X1396 SGTC_2378 9074213 121.43 µM 3.2259875918487 0.00135595772497997 no 70 0.00062769399691451 50 657714 SGTC_92 0063-0024 660.874 µM 3.20512037811303 0.00144572475574075 no 71 0.000675030024236056 36 3594437 SGTC_2233 sulbentine 40.3845 µM 3.19307922856967 0.00149995971818399 no 72 0.000703821595137756 97 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1711 st032263 62.8 µM 3.18748333940946 0.00152579066524803 no 73 0.000717583629046684 40 3958979 SGTC_1867 st057372 64 µM 3.16759999187534 0.00162088905954029 no 74 0.000768514214862564 27 688837 SGTC_2682 pyrogallin 40.03 µM 3.14772629798835 0.00172130825912655 no 75 0.000822728424437594 57 822798 An ATP competetive kinase inhibitor. SGTC_1614 st002383 48.6 µM 3.10789387330522 0.00193981078563711 no 76 0.0009421285897418 47 1947235 SGTC_21 0849-0113 22.993 µM 3.06952170976382 0.00217383148989391 no 77 0.00107200911254902 71 1560156 SGTC_3242 9133940 49.47 µM 3.06903760779385 0.00217694077865266 no 78 0.00107374777881136 43 17248444 SGTC_1616 st002734 56.1 µM 3.06638612649025 0.00219404233053025 no 79 0.00108331659622889 72 4026101 SGTC_263 alizarin 107.927 µM 3.06413765037333 0.00220863989198167 no 80 0.00109149221167133 124 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2317 5986382 200 µM 3.04872739834319 0.00231107833101344 no 81 0.00114906456065336 42 877883 SGTC_3311 9131146 2.8755 µM 3.03847868546159 0.0023815681347522 no 82 0.00118887962323352 173 4900406 YPR165W RHO1 SGTC_2885 9057732 51.95 µM 3.03130030927779 0.00243209308752189 no 83 0.00121751464318833 48 6471414 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 3.00195542272283 0.00264887558453709 no 84 0.00134125726934985 67 6708514 SGTC_2248 tofa 1.1 µM 2.99824418657125 0.00267750056672349 no 85 0.00135770005689403 74 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_78 0336-0123 156.75 µM 2.99795081665291 0.00267977521630782 no 86 0.00135900766750867 52 6765896 SGTC_1755 st041960 45.185 µM 2.9732059272242 0.00287803350210472 no 87 0.00147353328189318 63 2257073 SGTC_138 0850-0259 40.9225 µM 2.96065305367119 0.002983582573365 no 88 0.0015349377302419 278 6813004 SGTC_487 nimodipine 119 µM 2.95962801526419 0.00299235363021331 no 89 0.00154005351686884 26 4497 L-type voltage-gated calcium channels inhibitor SGTC_3111 9122088 49.47 µM 2.95568964489465 0.00302627003718504 no 90 0.00155985418936111 22 16876704 SGTC_753 1322-0200 289 µM 2.94856701207197 0.00308848921088043 no 91 0.001596254585431 70 5403907 SGTC_3189 9110682 49.47 µM 2.92306905811982 0.00332077782705522 no 92 0.00173299817581979 75 17122418 SGTC_2906 7926292 26.41 µM 2.91937577419205 0.00335569589753372 no 93 0.00175366576722358 84 2966319 SGTC_2539 epi(13)torulosol 80 µM 2.90874313719862 0.00345807217880622 no 94 0.00181442439008623 72 6708597 SGTC_690 glyoxal 20.3 µM 2.90473900200465 0.0034973474773855 no 95 0.00183779729694214 152 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1162 k048-0130 20.1 µM 2.90150827697793 0.00352932815879088 no 96 0.00185685484261952 52 6797406 SGTC_2847 9005661 71.43 µM 2.87849232306061 0.00376486326622365 no 97 0.00199790503062964 31 2991449 SGTC_3011 9081274 71.4286 µM 2.85254417864985 0.00404722793119804 no 98 0.00216853916750683 70 6625322 SGTC_1050 3232-1156 69.3 µM 2.85069202053653 0.00406808985737995 no 99 0.00218121004664292 71 700529 SGTC_2196 6573537 42.6665 µM 2.84377873061209 0.00414681097607139 no 100 0.0022290998156634 45 2903087 SGTC_2697 mebhydrolin 72.4 µM 2.82216109180518 0.00440183780050858 no 101 0.00238506048810037 145 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1550 gossypolone 36.6 µM 2.77327830320803 0.00503084986382219 no 102 0.00277473192742453 73 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2878 9043973 25.97 µM 2.76753117987198 0.00510982827550905 no 103 0.00282413211180156 67 6465167 SGTC_2467 5474540 200 µM 2.76022984888567 0.00521175577857138 no 104 0.00288803537338261 87 5413519 SGTC_2772 vinpocetine 57.06 µM 2.73991534124146 0.00550493139883803 no 105 0.00307275058523142 83 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_3044 9093193 49.47 µM 2.73819174572468 0.0055304678561676 no 106 0.00308890224666146 103 25236277 SGTC_2835 9006588 71.43 µM 2.72883450145119 0.00567094801167722 no 107 0.0031779296469605 121 2345538 SGTC_1556 plumbagin 1.48 µM 2.72881657983261 0.00567122008075502 no 108 0.00317810235111763 61 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2760 etidronate 98.04 µM 2.72537832131201 0.0057236313394659 no 109 0.003211392274937 93 3305 A chelator and antioxidant. SGTC_2292 7671323 168.05 µM 2.72093664967097 0.00579197437660029 no 110 0.0032548617720103 116 937504 SGTC_1674 st016616 23.6 µM 2.71161421071235 0.00593777603737157 no 111 0.00334782351295791 101 625830 SGTC_1285 0929-0069 65.5 µM 2.70928290649242 0.0059747422271834 no 112 0.00337144083318069 95 1206237 SGTC_2405 ticlatone 3.52 µM 2.69502673672596 0.0062052652051885 no 113 0.00351914915751542 155 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2242 6630449 61.2675 µM 2.68128758601484 0.00643484691394444 no 114 0.00366697291350316 112 691249 YDR170C SEC7 SGTC_2199 6590217 200 µM 2.65965521371372 0.0068115711763466 no 115 0.00391103397690523 34 703109 SGTC_1260 0700-1617 7.75 µM 2.63534877378606 0.00725799162637437 no 116 0.00420254347679204 134 2853078 SGTC_1750 st081859 2.357 µM 2.62655331339026 0.00742577765166123 no 117 0.00431272396921697 316 5291695 SGTC_2297 7971671 152.32 µM 2.62270943920563 0.00750017200916117 no 118 0.0043616816467275 98 909016 SGTC_1554 st069299 38.7 µM 2.61910270787683 0.00757057294032556 no 119 0.00440806995807602 94 24207999 SGTC_3077 9117319 49.47 µM 2.60775316524532 0.00779591957395117 no 120 0.00455693240321167 72 17154678 SGTC_3133 9127736 49.47 µM 2.60741764875295 0.00780267017565051 no 121 0.00456140058594841 100 27243420 SGTC_3165 9101544 49.47 µM 2.60106034056418 0.00793155495123666 no 122 0.00464680528804233 76 5002184 SGTC_2254 7938975 95.19 µM 2.59030321231404 0.00815390686903569 no 123 0.00479457145844699 148 2969277 SGTC_3315 9136395 68.55 µM 2.56921835642423 0.00860567246773632 no 124 0.00509641043844195 88 16876844 SGTC_454 lyso-paf C-16 6.67 µM 2.56628632767847 0.00867020221915815 no 125 0.00513969678625887 107 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1990 st072050 59.8 µM 2.562563954623 0.00875273739185085 no 126 0.00519512247577295 91 17233948 SGTC_947 3447-0010 211 µM 2.55045644227758 0.00902597686389537 no 127 0.00537909832138173 103 748350 SGTC_129 0088-0017 176.636 µM 2.51930658553149 0.00976356234544652 no 128 0.00587931110877898 165 182446 SGTC_1194 1488-0194 225 µM 2.51685192654237 0.00982386266384726 no 129 0.0059204290422456 139 1391452 SGTC_2333 9017922 200 µM 2.51360080560815 0.0099042291354214 no 130 0.00597528095699589 126 3163164 SGTC_1915 st067105 30.6 µM 2.51068765522173 0.00997672814225082 no 131 0.00602481298095728 164 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_459 nigericin 15.3 µM 2.49099486938948 0.0104790795361758 no 132 0.00636929796460633 165 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1492 4158-0558 28.5 µM 2.48422746457929 0.0106567301207876 no 133 0.00649164232119865 113 3967268 SGTC_2999 9069765 71.4286 µM 2.47216684794927 0.0109798410528595 no 134 0.00671484107653996 136 2097066 SGTC_1845 st056753 3.01 µM 2.47034299508393 0.0110294377490515 no 135 0.00674917789601574 135 5375839 SGTC_2330 7979373 200 µM 2.468970565423 0.0110668871161864 no 136 0.00677511818927384 137 1863007 SGTC_3299 9121982 43.1275 µM 2.46058899224545 0.0112980031972039 no 137 0.00693545834775351 142 17594604 YPL160W CDC60 SGTC_2587 piperic acid 92.2 µM 2.45661765838593 0.0114089669391132 no 138 0.00701259333192843 119 5370536 SGTC_952 1185-0122 232 µM 2.44539265145485 0.0117277420778044 no 139 0.00723472580978266 120 678600 SGTC_2117 5521686 200 µM 2.44380003436139 0.0117735907506407 no 140 0.00726673971241232 126 803312 SGTC_195 4234-0266 16.654 µM 2.43542021156324 0.0120174022503017 no 141 0.00743725231786269 154 2303354 SGTC_1960 st011366 51.8 µM 2.433449119593 0.0120753832783638 no 142 0.00747786860558581 83 3972846 SGTC_1479 0549-0158 134 µM 2.42958806292064 0.0121896620735767 no 143 0.00755799612534388 151 5440202 SGTC_623 k072-0108 16.9 µM 2.42057452157449 0.0124600973058028 no 144 0.00774800136943878 133 5382803 SGTC_3130 9127414 49.47 µM 2.41340214263928 0.0126789889432192 no 145 0.00790218560388159 98 1494646 SGTC_2225 6654152 15.4 µM 2.40691287047853 0.0128798925878666 no 146 0.0080440038040489 76 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1713 st033146 12.748 µM 2.39980284644194 0.0131031694691956 no 147 0.00820195213061867 159 674619 SGTC_3293 9120939 62.045 µM 2.3885522426678 0.0134633078089852 no 148 0.00845745162766011 126 934087 SGTC_1699 st031318 29.054 µM 2.38807471973747 0.0134787808270866 no 149 0.00846844896352794 116 5340658 SGTC_3317 9138495 8.753 µM 2.38071311082273 0.0137192663065449 no 150 0.00863958155850378 137 17020139 SGTC_1333 1482-0047 286 µM 2.3766581221145 0.0138533070233714 no 151 0.00873513590979673 147 3811116 SGTC_2198 6589944 200 µM 2.34774794568813 0.0148420869355231 no 152 0.00944364883606054 96 5290268 SGTC_3229 9132204 49.47 µM 2.341427206386 0.0150661756961234 no 153 0.00960508583393445 71 17682924 SGTC_1204 4049-0315 18.3 µM 2.34129390423833 0.0150709327856915 no 154 0.00960851629675008 153 588402 SGTC_108 0509-0257 621.132 µM 2.33925622007127 0.0151438114722223 no 155 0.00966108851383102 202 536624 SGTC_2534 helenine 20.12 µM 2.33382128934309 0.0153396767539534 no 156 0.00980254078205492 107 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_839 0122-0028 230 µM 2.33359414533731 0.0153479097629645 no 157 0.00980849172582873 189 759448 SGTC_451 chloral hydrate 100 µM 2.32804170003758 0.0155503457032892 no 158 0.00995494475701197 222 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_720 r052-1644 49.9 µM 2.32312499199627 0.0157315121763536 no 159 0.0100862193745 131 1422863 YOR257W CDC31 SGTC_2943 9068529 45.32 µM 2.29926301174422 0.0166366885694956 no 160 0.010745004417682 163 3270634 SGTC_3336 9143619 71.43 µM 2.29414180485617 0.0168366607954171 no 161 0.0108911773768921 142 45595730 SGTC_560 2332-1943 155 µM 2.28820061041006 0.0170712242086092 no 162 0.0110629205948827 110 21177716 SGTC_2555 cholic acid 100 µM 2.28737426404593 0.0171040692966862 no 163 0.0110869935717835 125 6708657 Influences liver metabolism. SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 2.28683266864773 0.0171256255711521 no 164 0.0111027959367539 152 688751 SGTC_640 3381-0960 37.1 µM 2.28574682926331 0.0171689134794977 no 165 0.0111345369570319 126 1745025 SGTC_3204 9114183 49.47 µM 2.28356829253875 0.0172560447164013 no 166 0.0111984575078731 159 17027248 SGTC_2177 5811945 192 µM 2.28095679615029 0.0173609898795472 no 167 0.0112755017759725 143 5343475 SGTC_855 0428-0020 25 µM 2.26593796535073 0.0179751739952593 no 168 0.0117275908502112 129 6812414 SGTC_617 3770-0098 35 µM 2.26488281507297 0.0180190116363299 no 169 0.0117599358039606 128 5962639 SGTC_1442 4112-3290 3 µM 2.25293665860925 0.0185217217038877 no 170 0.0121315715262347 154 704353 SGTC_3016 9080866 49.47 µM 2.23696516250203 0.0192124405791156 no 171 0.012644308518181 179 17066299 SGTC_1958 st076513 41.9 µM 2.2273574965688 0.0196383983283508 no 172 0.0129616953365001 192 732122 YGL099W LSG1 SGTC_744 1594-0068 283 µM 2.22472895799962 0.0197563226846276 no 173 0.0130497195274793 203 668392 SGTC_210 3551-0445 56.827 µM 2.22188389827849 0.0198846376957751 no 174 0.0131455764220662 187 2865180 YOR207C RET1 SGTC_380 3970-0968 6 µM 2.21113358139316 0.0203758909004738 no 175 0.0135132940479751 152 2891601 SGTC_2096 5468907 200 µM 2.20539198862147 0.0206424502497748 no 176 0.0137132998676918 148 759785 SGTC_393 acivicin 6.25 µM 2.20391072909183 0.0207116965934663 no 177 0.0137653114302656 136 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 2.18962078398053 0.0213898875765039 no 178 0.014275875203525 159 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_848 0368-0089 85.6 µM 2.1778837091405 0.0219608770663497 no 179 0.0147073478265482 184 762535 SGTC_2863 9028737 58.44 µM 2.17458633710584 0.0221235855737911 no 180 0.0148305645517548 105 6460917 SGTC_2526 patulin 37.61 µM 2.16523086717607 0.022590778381064 no 181 0.0151850048039613 296 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1877 wortmannin 25 µM 2.15866641808561 0.0229235360906059 no 182 0.0154380279482262 285 312145 A covalent inhibitor of PI 3-kinase. SGTC_2111 5486399 200 µM 2.15293281020947 0.0232175467538012 no 183 0.015661979722023 232 689674 SGTC_756 0508-1999 28.3 µM 2.14464747627001 0.0236480092785591 no 184 0.0159905216646314 171 6753853 SGTC_2266 7929956 200 µM 2.14360723681332 0.0237025259296105 no 185 0.0160321852202586 197 2967153 SGTC_3188 9110789 49.47 µM 2.13205285637744 0.024315203519773 no 186 0.0165012507943557 199 849217 SGTC_1707 st032323 6.317 µM 2.12909022117598 0.0244744237118942 no 187 0.0166233983323971 251 3132057 YMR211W DML1 SGTC_428 3448-4153 16.5 µM 2.12777999552673 0.0245451174482038 no 188 0.0166776643588226 197 3834874 SGTC_2433 5607874 27.82 µM 2.12514274991752 0.0246879307583216 no 189 0.0167873516844801 197 2252428 SGTC_1099 5-nonyloxytryptamine 2.85 µM 2.12425725949069 0.0247360382969739 no 190 0.0168243187787449 171 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2531 methyl deoxycholate 70.07 µM 2.12384653717575 0.0247583789872825 no 191 0.0168414890695484 186 16667744 Haematoxylin. SGTC_2381 9035592 200 µM 2.12342581043396 0.0247812814014434 no 192 0.0168590931328869 170 4749657 SGTC_1487 3970-0795 2.82 µM 2.1230355437541 0.0248025415954963 no 193 0.016875436751707 180 3765103 SGTC_518 1021-0119 62.6 µM 2.12275570234349 0.0248177956711329 no 194 0.0168871643115862 229 1097762 SGTC_2436 5633522 8.09 µM 2.11924607000244 0.0250097738088335 no 195 0.0170348383567919 197 5724242 SGTC_1318 1280-3875 124 µM 2.11879114842074 0.025034749089632 no 196 0.0170540605713799 222 373245 SGTC_1094 duloxetine 25.4 µM 2.11695069062893 0.0251360040697348 no 197 0.017132016446449 194 60834 A selective serotonin reuptake inhibitor. SGTC_1357 1503-1303 39.5 µM 2.11567480623937 0.0252063996393194 no 198 0.0171862373622379 217 292895 SGTC_485 niflumic acid 177 µM 2.10369941157886 0.0258752171375434 no 199 0.0177023379151194 160 4488 A COX2 inhibitor. SGTC_887 0885-0007 9.62 µM 2.10343867916158 0.0258899424543774 no 200 0.0177137201611132 222 5719458 SGTC_767 0929-0023 86 µM 2.10271057030923 0.0259311008022062 no 201 0.017745538749621 305 1204563 SGTC_1181 1222-0449 220 µM 2.09815317065897 0.0261899657583397 no 202 0.0179458084351457 191 658318 SGTC_1433 4060-0023 7.6 µM 2.09065472442991 0.0266205859504456 no 203 0.018279513165625 183 3840627 SGTC_458 nppb 133 µM 2.08731543506725 0.0268142492102446 no 204 0.0184298152245846 159 4549 A chloride channel blocker. SGTC_871 0574-0004 149 µM 2.08574381795453 0.0269058020148302 no 205 0.0185009174934445 231 9551173 SGTC_1680 diphenhydramine 100 µM 2.08521459133883 0.026936690194638 no 206 0.018524912997327 209 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_379 3970-0972 5.9 µM 2.0833025660265 0.0270485318368921 no 207 0.018611826499569 211 2898042 YBL034C STU1 SGTC_2558 carylophyllene oxide 100 µM 2.07936701264742 0.0272799573728269 no 208 0.0187918150329488 193 6708694 An oxygenated terpenoid and antifungal agent. SGTC_659 k018-0002 107 µM 2.07193246864621 0.0277216444439036 no 209 0.0191358697440401 193 6797879 YHR007C ERG11 SGTC_1078 idebenone 36.1 µM 2.07126416930693 0.0277616384612243 no 210 0.0191670578847255 279 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_712 r015-0009 80.6 µM 2.05762374398446 0.0285885045528084 no 211 0.0198131327854841 172 6813872 YLR060W FRS1 SGTC_372 0155-0182 15.9 µM 2.05628674151599 0.0286706430503624 no 212 0.0198774427568879 215 771486 SGTC_3163 9099914 49.47 µM 2.05445360738204 0.0287835802252739 no 213 0.0199659045784111 101 16268368 SGTC_1924 st058459 75.1 µM 2.05422600247154 0.0287976284663094 no 214 0.0199769114166074 172 688683 SGTC_1328 1441-0025 69.2 µM 2.0407570893717 0.029639163923319 no 215 0.0206374888530722 162 4562601 SGTC_2115 tiliquinol 12.7705 µM 2.03913819627329 0.0297416723478024 no 216 0.0207181185106128 165 71208 A bioactive hydroxyquinoline. SGTC_2532 xanthone 78.9 µM 2.03785918775607 0.0298228671066852 no 217 0.0207820085636047 203 7020 An insecticide. SGTC_11 0438-0307 1.3 µM 2.02366246173085 0.0307365218600169 no 218 0.0215024467309842 184 4011476 SGTC_1514 1189-1591 158 µM 2.01429119157919 0.0313522323279147 no 219 0.0219894851120881 269 767698 YMR146C TIF34 SGTC_2737 bleomycin 30.5 nM 2.01368124966781 0.0313926576880906 no 220 0.0220215049290477 286 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1473 k844-0725 134 µM 2.01085183996745 0.0315807476398095 no 221 0.0221705542914911 227 54682906 SGTC_366 0181-0206 4.31 µM 2.00825290708619 0.0317543360132585 no 222 0.0223082117149898 267 274874 SGTC_2071 5230951 39.92 µM 2.00786088799202 0.0317805881153701 no 223 0.0223290382059985 217 1799272 SGTC_1441 4106-0040 13 µM 1.99986845238579 0.0323197335884389 no 224 0.0227572352653758 196 2904180 SGTC_1477 0139-0234 16 µM 1.98663154618046 0.0332292436008527 no 225 0.0234816213553762 193 620880 SGTC_2481 5478948 45.16 µM 1.98609505510629 0.0332665460702024 no 226 0.0235113851242985 247 77792 SGTC_2818 7996756 12.99 µM 1.98424495396404 0.0333954490802814 no 227 0.0236142696758461 149 2241621 SGTC_660 4031-1742 102 µM 1.9809101246107 0.0336288369872197 no 228 0.0238006767333651 268 6738706 SGTC_2205 7238770 200 µM 1.9795501481876 0.033724399445958 no 229 0.0238770496881081 156 279867 SGTC_1900 st060200 72.8 µM 1.9732779262958 0.0341680302401992 no 230 0.0242319531971089 204 688945 SGTC_2869 9037858 32.47 µM 1.96627410918187 0.0346690644349885 no 231 0.024633477938787 172 27187042 SGTC_1192 1488-0095 21.4 µM 1.96299012335976 0.034906061344159 no 232 0.0248236608365632 204 915875 SGTC_2831 7999036 19.48 µM 1.9622579152754 0.0349590838522786 no 233 0.0248662321124855 279 2988270 SGTC_2543 pimpinellin 60.67 µM 1.95844505349734 0.0352362598926411 no 234 0.0250889062702081 223 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_599 1935-0052 86.5 µM 1.93681846577177 0.0368427067587059 no 235 0.0263837689296113 241 9557311 SGTC_1935 st074532 41.6 µM 1.93477463779023 0.0369975732522155 no 236 0.0265089783364137 293 2829742 SGTC_3141 9094609 49.47 µM 1.9327396781227 0.0371522960351268 no 237 0.0266341373258729 254 25236309 YDL196W YDL196W SGTC_1905 st060207 84.5 µM 1.93224809393204 0.0371897515271706 no 238 0.0266644458319813 196 1948547 SGTC_3 0833-0587 95.581 µM 1.92760645095074 0.0375449375727013 no 239 0.026952047937718 211 5382644 SGTC_1185 1319-0113 81.3 µM 1.92745756525906 0.0375563762383104 no 240 0.0269613157790807 210 4672763 SGTC_1644 st010134 20.9 µM 1.92504842627393 0.037741862664276 no 241 0.0271116500842695 196 3818134 SGTC_190 3970-0790 3.722 µM 1.91997059336313 0.0381352686356731 no 242 0.0274308069783357 208 2832352 SGTC_3259 9138485 49.47 µM 1.91933729221323 0.0381845674826137 no 243 0.0274708306848289 261 17646153 SGTC_50 0929-0078 56.389 µM 1.91885568802343 0.0382220923751041 no 244 0.027501299948202 267 1377751 SGTC_1300 1094-0077 113 µM 1.91771553259182 0.038311049121326 no 245 0.0275735455641479 222 5532636 SGTC_1612 st002233 45.4 µM 1.90518377559163 0.0392999636506689 no 246 0.0283780932207691 243 1035021 SGTC_572 0960-0087 17.7 µM 1.90241842352048 0.0395209591088803 no 247 0.028558237165974 311 6796365 SGTC_2561 acetosyringone 100 µM 1.90198264760971 0.0395558765296301 no 248 0.0285867115874966 305 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_991 3996-0057 64.7 µM 1.90117297188715 0.0396208200429728 no 249 0.0286396800283172 233 715343 SGTC_354 2783-3500 4.88 µM 1.90093199443078 0.039640165408494 no 250 0.028655460364007 292 6740761 SGTC_2023 5144124 124 µM 1.89118206664372 0.0404293418639568 no 251 0.0293000222060592 242 2830192 SGTC_332 4112-0506 40.9 µM 1.88813756012606 0.0406783671463421 no 252 0.0295037428083239 230 2790355 SGTC_925 2064-1272 59.6 µM 1.8880664305651 0.0406842000338136 no 253 0.0295085164043813 245 6815817 SGTC_992 3909-8734 162 µM 1.88149454394446 0.0412260544660992 no 254 0.0299523383881416 241 4288319 SGTC_9 0092-0002 10.449 µM 1.87853114507154 0.041472294349967 no 255 0.0301542702661311 258 759368 SGTC_1133 3473-0247 50 µM 1.87655542458188 0.0416371255258478 no 256 0.0302895258090974 317 711311 SGTC_1418 3966-3099 2.4 µM 1.87370378880439 0.0418759682456524 no 257 0.0304856317178351 275 740335 SGTC_3025 9087895 49.47 µM 1.87096948456575 0.0421060243263452 no 258 0.0306746553977146 264 17173641 SGTC_2061 5245884 80.95 µM 1.86965776735711 0.0422167507327505 no 259 0.0307656788799925 271 573863 SGTC_2729 fluphenazine 10.66 µM 1.86338501354901 0.0427495162364809 no 260 0.0312040584922307 278 3372 An atypical antipsychotic. SGTC_1910 st062352 60.4 µM 1.86243424031871 0.0428307407843863 no 261 0.0312709532764966 307 2245730 SGTC_3174 9107204 49.47 µM 1.86228186591662 0.0428437697171483 no 262 0.031281685098792 266 3938802 SGTC_377 3970-0964 33.1 µM 1.86174985951884 0.0428892845982327 no 263 0.0313191785196779 363 16481235 SGTC_2212 7123476 200 µM 1.86132333816354 0.0429258031046552 no 264 0.0313492646616999 160 1085715 SGTC_2009 4012297 12.05 µM 1.85601984790111 0.0433819866950753 no 265 0.0317253645321633 292 45595307 SGTC_3338 9144300 39.5675 µM 1.85534612550654 0.0434402165816665 no 266 0.0317734077024661 268 4901274 SGTC_2855 9016525 58.44 µM 1.85529508602429 0.0434446304984944 no 267 0.031777049777877 262 43811474 SGTC_1698 5-fluorocytosine 1.055 µM 1.85027501573791 0.0438805405089963 no 268 0.0321369608621556 231 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_799 1310-0557 151 µM 1.85022670752803 0.0438847523521814 no 269 0.0321404405718341 285 5354492 SGTC_556 4058-0063 51.5 µM 1.84961016715228 0.0439385352406677 no 270 0.0321848781828186 279 6615692 SGTC_479 n-linoleoylglycine 10 µM 1.84699675636877 0.0441671023644248 no 271 0.0323738051969405 213 6433346 An anti-infammatory. SGTC_191 3914-0123 66.505 µM 1.84475700669101 0.0443637512233829 no 272 0.0325364470603768 135 3144412 SGTC_2344 7990960 76.95 µM 1.84268247211958 0.0445465231257427 no 273 0.032687692321179 262 140813 SGTC_3282 9108498 15.4605 µM 1.8391593091162 0.0448583124122626 no 274 0.0329458788452501 285 16459645 SGTC_1242 0402-0103 60.1 µM 1.82907873772413 0.0457601266425184 no 275 0.0336939068417515 250 432868 SGTC_3279 9140807 49.47 µM 1.82643643391552 0.0459989035386733 no 276 0.0338922740146209 231 45595718 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.82432226165429 0.0461906747915237 no 277 0.0340516834038951 282 6312947 SGTC_395 anisomycin 6.25 µM 1.82010132079478 0.0465754661277495 no 278 0.0343717882601794 209 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2671 danthron 100 µM 1.8200242701168 0.0465825140918737 no 279 0.034377654480558 280 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_3166 9102297 49.47 µM 1.81601120778598 0.0469507808244751 no 280 0.0346843264480241 306 25237072 SGTC_1457 k015-0032 57.3 µM 1.81357307250611 0.0471756589795231 no 281 0.0348717396050229 311 4302660 SGTC_3114 9122766 49.47 µM 1.81294552032212 0.0472336799167731 no 282 0.0349201122126601 264 17176985 SGTC_2619 obliquin 87.91 µM 1.80900050549959 0.0475997311009082 no 283 0.0352254624108936 435 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1092 toremifene 6.32 µM 1.80025616508543 0.0484192041329492 no 284 0.0359100995010618 331 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2908 7930301 100 µM 1.79862751525466 0.0485730717614238 no 285 0.0360388109246375 330 2223178 SGTC_411 enrofloxacin 100 µM 1.79705991786505 0.0487215404160077 no 286 0.0361630540186293 255 71188 A bacterial gyrase inhibitor. SGTC_3187 9109394 49.47 µM 1.79495092028167 0.048921857638149 no 287 0.0363307599741618 301 17098090 SGTC_2370 9071495 200 µM 1.79445861527078 0.048968712456075 no 288 0.0363699992175447 295 21791103 SGTC_1984 st072354 53.1 µM 1.79309119153167 0.0490990442574351 no 289 0.0364791719362757 246 5762938 SGTC_2622 2-methoxyxanthone 59.94 µM 1.79187113540534 0.0492155639212259 no 290 0.03657680531062 271 71034 A hepatoprotective. SGTC_626 0214-0009 33 µM 1.79136696078325 0.0492637788108636 no 291 0.0366172135926186 286 3437874 SGTC_410 α-linolenic acid 100 µM 1.78896253422499 0.0494942363914336 no 292 0.0368104247756072 304 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2871 9038510 12.99 µM 1.78728268083298 0.0496557556537566 no 293 0.036945905895945 294 4945164 SGTC_1015 4130-4525 82 µM 1.78534569911289 0.0498425197957856 no 294 0.0371026302950033 289 1363237 SGTC_1955 wogonin 32.4 µM 1.78364838712789 0.0500066351600804 no 295 0.0372404088846593 274 5281703 A flavanone. SGTC_1214 0358-0031 63.7 µM 1.78276932886483 0.0500918016975323 no 296 0.0373119302199026 290 4301366 SGTC_1355 1499-0035 1.68 µM 1.77922689000366 0.0504361793843587 no 297 0.0376012857622433 292 1548538 SGTC_2979 9012552 45.46 µM 1.77860277136005 0.0504970479904037 no 298 0.0376524547171569 220 17100905 SGTC_891 0929-0073 133 µM 1.77640242713803 0.0507121086154619 no 299 0.0378333056739516 265 5603632 SGTC_624 k048-0052 28 µM 1.77465546863571 0.0508833744584954 no 300 0.0379773962027546 271 6835531 SGTC_400 oxethazaine 37.5 µM 1.76885205476521 0.0514556290937588 no 301 0.0384592835630132 282 4621 A local anesthetic. SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.76774837267567 0.0515650364436435 no 302 0.0385514896340527 357 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1853 st056710 91.2 µM 1.76026779427957 0.0523114649975156 no 303 0.0391812060123895 289 269167 SGTC_854 0422-0053 192 µM 1.75196462066934 0.0531499933459802 no 304 0.0398899458166603 281 3596728 SGTC_3088 9117578 49.47 µM 1.7504811379911 0.0533009246112968 no 305 0.040017663040735 272 678341 SGTC_300 r073-0011 5.04 µM 1.74820984855633 0.053532666265401 no 306 0.0402138484277595 348 2735780 SGTC_1821 st053465 65.6 µM 1.74588629452169 0.0537705658327344 no 307 0.0404153559375792 264 675086 SGTC_558 k064-0027 21.3 µM 1.74462102995305 0.0539004629534391 no 308 0.0405254288465388 313 5088526 SGTC_1786 berberine 21.6 µM 1.74335931508562 0.0540302429313764 no 309 0.0406354351668809 345 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.74038098854499 0.0543375746649685 no 310 0.0408960707670741 271 229346 A bile salt which induces apoptosis. SGTC_579 4491-1009 110 µM 1.74003518090326 0.0543733477810697 no 311 0.0409264203282777 409 1271041 SGTC_1462 k081-0014 26.5 µM 1.73267306009413 0.0551393740083162 no 312 0.0415768977088402 205 3270634 SGTC_838 0109-0203 71.4 µM 1.73128878722569 0.0552843548173015 no 313 0.0417001351539531 298 759422 SGTC_2026 5148700 152 µM 1.7226283837037 0.0561982409108601 no 314 0.0424778743780986 304 79838 SGTC_16 erodoxin 22.806 µM 1.72235868392939 0.0562268909899394 no 315 0.0425022815953861 411 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_666 0272-0154 136 µM 1.72114483874944 0.0563559797612092 no 316 0.0426122722559453 361 6870312 SGTC_1290 0986-0249 10.2 µM 1.71801015760643 0.056690424352937 no 317 0.0428973812724054 262 53329 SGTC_2181 6316240 54.2555 µM 1.71692167302972 0.0568069217081189 no 318 0.0429967421737029 291 12779990 SGTC_1820 st053765 18.6 µM 1.71580887950668 0.0569262156108412 no 319 0.0430985142235118 302 3690829 SGTC_755 1995-0008 37.3 µM 1.71563111572455 0.0569452905374296 no 320 0.0431147898635942 296 689533 SGTC_1659 st012954 42.1 µM 1.70882864728736 0.0576790171845078 no 321 0.0437413472938177 275 24207262 SGTC_2273 7815444 169.05 µM 1.7061978513396 0.0579647652641184 no 322 0.0439856243340624 316 2824616 SGTC_3067 9117431 49.47 µM 1.69855391987274 0.0588013385850547 no 323 0.044701632519846 265 17150885 SGTC_2715 st079500 56.4 µM 1.68454112229148 0.0603595141636631 no 324 0.046038569567487 287 28246688 SGTC_424 splitomicin 100 mM 1.67694403976909 0.0612176909459846 no 325 0.0467767126004442 326 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1273 0849-0096 14.1 µM 1.67341449272501 0.0616196234074271 no 326 0.0471228633743559 336 5286025 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 1.67007115743421 0.0620022483218236 no 327 0.0474526429385101 449 6708739 YPR165W RHO1 SGTC_1027 k015-0025 8.67 µM 1.66288592719184 0.0628308271683267 no 328 0.0481676359486121 354 3598955 SGTC_423 5-fluorouracil 457 µM 1.66137408951477 0.0630062614036625 no 329 0.0483191691492202 350 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_161 4065-0411 162.148 µM 1.65475867172948 0.0637784082118252 no 330 0.0489867301859891 426 1906281 YLR208W SEC13 SGTC_2953 9074162 66.49 µM 1.65200458950756 0.0641020246190046 no 331 0.0492668076272246 295 16451992 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.64988136188149 0.064352383232846 no 332 0.0494836017394247 431 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3047 9092122 49.47 µM 1.64968441177194 0.064375644897266 no 333 0.0495037500436718 335 17173831 SGTC_1244 0416-0015 52.5 µM 1.64701667861136 0.064691373344588 no 334 0.0497773088474164 360 96201 SGTC_2178 5812956 200 µM 1.64649932664042 0.064752741370778 no 335 0.0498304993024727 316 5403383 SGTC_124 0136-0217 7.121 µM 1.6436148923798 0.0650957204705585 no 336 0.0501278878945318 412 3976905 SGTC_1642 st009582 77.7 µM 1.6417820660203 0.0653143876184167 no 337 0.0503175885004219 306 6739311 SGTC_2402 5553605 200 µM 1.63507667678773 0.0661192390970136 no 338 0.0510164873783942 368 6758546 SGTC_3283 9109332 35.8195 µM 1.63470673794569 0.0661638656966548 no 339 0.051055269669557 273 17027281 SGTC_2752 diclazuril 33.15 µM 1.62307670741593 0.0675787533948743 no 340 0.0522865040822641 530 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1249 0481-0015 10.2 µM 1.61675427442623 0.0683576772777664 no 341 0.0529656666035282 315 4227577 SGTC_184 1494-0393 24.714 µM 1.61334129191357 0.0687810263153726 no 342 0.0533351901271003 399 3090647 SGTC_3198 9112019 49.47 µM 1.61197697734493 0.0689508214460134 no 343 0.0534834748579578 343 45595555 SGTC_495 decylubiquinone 155 µM 1.61148441591548 0.0690122022664725 no 344 0.053537090601428 359 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2161 5662504 8.5105 µM 1.61053140418716 0.0691310819186437 no 345 0.0536409476576562 353 2859334 SGTC_2451 5856223 45.7 µM 1.60954869229945 0.0692538315860343 no 346 0.0537482084343405 357 2179896 SGTC_2193 5925765 200 µM 1.60939993306173 0.0692724275939228 no 347 0.0537644599606565 287 877370 SGTC_432 NS 1619 61.3 µM 1.60887367875476 0.0693382441611957 no 348 0.0538219829926666 339 4552 A K+/calcium channel activator. SGTC_2978 9011784 42.97 µM 1.60772117098929 0.0694825520464131 no 349 0.053948129850168 436 2994934 SGTC_2734 clemastine 41.6 µM 1.60483384950381 0.0698450950378315 no 350 0.054265187248701 199 26987 Clemastine is a selective histamine H1 antagonist. SGTC_520 3584-0023 682 µM 1.604281001742 0.0699146784593236 no 351 0.0543260634240807 371 1340790 SGTC_2261 9010538 184.68 µM 1.60123845470923 0.0702985794499703 no 352 0.0546620573163543 301 6457250 SGTC_612 0302-0167 22.4 µM 1.59659672083212 0.0708873821335593 no 353 0.0551778151773687 450 235821 SGTC_2952 9073731 13.78 µM 1.59446507750913 0.0711590466678046 no 354 0.0554159532895683 427 16457353 SGTC_2416 tofa 880 nM 1.59433196420159 0.0711760376036073 no 355 0.0554308510195072 381 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_407 eburnamonine 100 µM 1.59366169378644 0.0712616400343002 no 356 0.0555059141715053 319 3195 SGTC_1557 sumaresinolic acid 42.3 µM 1.59323304835656 0.0713164251669794 no 357 0.0555539599507086 348 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1350 1495-0454 146 µM 1.58699321149612 0.0721176036373059 no 358 0.0562570910643495 437 1069057 SGTC_703 3875-0075 71.8 µM 1.58685904841462 0.072134905277292 no 359 0.0562722858190537 339 2850814 SGTC_726 3448-4391 34.2 µM 1.57989193293333 0.0730377626190469 no 360 0.0570658084920963 401 1356692 SGTC_2438 5259590 200 µM 1.57797490434041 0.0732876982221783 no 361 0.0572856876214977 386 1201127 SGTC_2673 kobusone 100 µM 1.57655666884189 0.0734730235759206 no 362 0.0574487848769259 323 6710676 An epoxy ketone and protein crosslinker. SGTC_3351 9150312 21.596 µM 1.57492697872898 0.0736864226586772 no 363 0.0576366502572515 397 4904905 SGTC_3343 9148379 18.9835 µM 1.57439092823531 0.0737567190234811 no 364 0.0576985499017096 369 1955036 SGTC_349 k015-0014 24 µM 1.5713347603978 0.0741584770511705 no 365 0.0580524555496307 367 2196908 SGTC_1412 3909-8563 178 µM 1.570620669013 0.0742525906217477 no 366 0.0581353930197654 415 23767530 SGTC_1151 3909-8316 15.3 µM 1.5684853041833 0.0745345649434789 no 367 0.0583839584837651 396 800431 SGTC_311 1315-0136 58 µM 1.56790254964888 0.0746116593056022 no 368 0.0584519383414102 359 6759207 SGTC_508 roscovitine 141 µM 1.56752200588088 0.0746620354309262 no 369 0.0584963633150619 327 160355 A CDKinase inhibitor. SGTC_144 4161-2749 112.381 µM 1.56458363937287 0.0750518887861089 no 370 0.0588402837593817 330 797501 YMR168C CEP3 SGTC_2389 9091542 195.52 µM 1.5597922346964 0.0756909245257748 no 371 0.0594044935596605 428 3626624 YOL127W RPL25 SGTC_1567 st069303 68.4 µM 1.55970409424431 0.0757027186352686 no 372 0.0594149120889948 423 5581319 SGTC_575 k072-0246 11.9 µM 1.55964942035525 0.0757100352739433 no 373 0.0594213754658923 393 6796779 SGTC_2143 5623677 140.463 µM 1.55793914473781 0.0759391820300761 no 374 0.0596238373515189 315 5375313 SGTC_1453 4237-0541 195 µM 1.54435107466706 0.0777785465994263 no 375 0.0612516528240112 382 739892 SGTC_1362 1611-0397 101 µM 1.54416025889857 0.0778046152531503 no 376 0.0612747568545936 388 27816 SGTC_2452 5863136 48.41 µM 1.53767076900536 0.0786951421571917 no 377 0.0620645671432436 402 2184096 SGTC_3260 9137109 49.47 µM 1.53567525991254 0.0789705248745099 no 378 0.062309022865421 291 17478346 SGTC_2059 5238311 157 µM 1.53019021320581 0.0797312283706458 no 379 0.0629848265724032 386 703021 SGTC_2510 benzyl isothiocyanate 8.31 µM 1.52618422072116 0.0802902997764955 no 380 0.0634819960229969 379 2346 DNA damaging agent; causes G2/M arrest. SGTC_31 0508-1974 57.237 µM 1.52557824695555 0.0803751260635256 no 381 0.0635574664897793 396 6810525 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.52372725132694 0.0806346541196039 no 382 0.0637884295081542 368 688803 SGTC_2751 anetholtrithion 17.25 µM 1.5202062604191 0.0811300784641051 no 383 0.0642295722411537 431 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2492 derrusnin 100 µM 1.51814700403565 0.0814208906770253 no 384 0.0644886719841457 338 1715307 Part of coumarin class of compounds. SGTC_2784 7567673 72.73 µM 1.51763129080302 0.0814938436646969 no 385 0.0645536870229655 456 3471247 SGTC_1967 st070177 51.4 µM 1.51293274891947 0.0821607731043499 no 386 0.0651483711354335 361 5729214 SGTC_3154 9100113 49.47 µM 1.51229896185526 0.0822510491120396 no 387 0.065228912521305 414 25237525 SGTC_450 aminopyrene 156 nM 1.51033194509714 0.0825317047787317 no 388 0.0654793721668296 438 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1126 isoteolin 1.0172 µM 1.50751323423848 0.0829351367448391 no 389 0.0658395770954929 426 133323 SGTC_1985 st071382 65.5 µM 1.50536843454085 0.0832431067459522 no 390 0.0661146898863874 403 6123237 SGTC_118 0083-0097 135.343 µM 1.50327958731298 0.08354386827406 no 391 0.0663834808414225 662 5207356 SGTC_3273 9137859 49.47 µM 1.50316135465493 0.083560916325018 no 392 0.0663987201767708 355 2377234 SGTC_2891 9063876 19.48 µM 1.50209964125535 0.0837141226866062 no 393 0.0665356887649263 316 6472478 SGTC_1510 1123-0200 71.5 µM 1.50198111248006 0.0837312395992463 no 394 0.0665509933824401 496 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2265 7929201 200 µM 1.5002094097797 0.0839874072085318 no 395 0.066780083277183 432 1265108 SGTC_1223 0764-0573 147 µM 1.49597735785253 0.0846016938072742 no 396 0.0673297778191069 471 1609797 SGTC_1248 0469-0687 58.6 µM 1.49272616218781 0.0850758924377579 no 397 0.0677544410780837 437 4017482 SGTC_2649 anisomycin 9.56 µM 1.48868800474392 0.0856676424357037 no 398 0.0682847725774624 375 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2771 fluoxetine 41.05 µM 1.47668578082415 0.0874446312593152 no 399 0.0698799427276604 397 3386 A selective serotonin reuptake inhibitor. SGTC_1389 3405-0187 19 µM 1.47501814755844 0.0876936937603643 no 400 0.0701038322636392 399 799890 SGTC_2153 5569715 200 µM 1.46794949386319 0.0887552813682152 no 401 0.071058971274706 410 2054701 SGTC_966 1300-0360 30.2 µM 1.46700866064926 0.0888972965831409 no 402 0.071186849694694 435 70588 SGTC_1292 0kpi-0043 232 µM 1.4630943520093 0.089489963048343 no 403 0.0717207815616125 428 3333905 SGTC_998 3996-0085 177 µM 1.45232102243761 0.091136323494474 no 404 0.0732061823870798 488 715391 SGTC_2718 lomofungin 53.02 µM 1.4521462039314 0.0911632229084891 no 405 0.0732304785531483 429 5351222 A RNA synthesis inhibitor. SGTC_1775 st081588 35.1725 µM 1.45024964712099 0.0914554255899329 no 406 0.0734944574698826 495 1426443 YGL099W LSG1 SGTC_1862 st057513 3.81 µM 1.44956602672523 0.0915609210778083 no 407 0.0735897877892931 430 5393163 SGTC_2284 7945075 39.21 µM 1.44890407857876 0.0916631580409565 no 408 0.0736821859980072 511 1245402 SGTC_2399 5884133 200 µM 1.44755262832071 0.0918721502183394 no 409 0.0738711038789898 472 722445 SGTC_1064 honokiol 6.76 µM 1.44688163094812 0.0919760462139725 no 410 0.0739650393434758 472 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2367 9070478 135.38 µM 1.44492803874918 0.0922790322191063 no 411 0.0742390498237108 478 572802 SGTC_1440 4100-1550 40 µM 1.44439771205572 0.0923614088512698 no 412 0.0743135669727353 387 742806 SGTC_613 3914-0030 117 µM 1.43905822716875 0.0931938350850124 no 413 0.0750670130429021 189 1145395 SGTC_1069 diphenylcyclopropenone 8.49 µM 1.43824035721588 0.093321829186563 no 414 0.0751829340453568 519 65057 A dermal irritant. YDR527W RBA50 SGTC_977 1348-1378 135 µM 1.43795207486246 0.0933669754197461 no 415 0.0752238263338914 457 X977 SGTC_1259 0671-0132 43 µM 1.43609759491276 0.0936577805886327 no 416 0.0754872861923446 467 X1259 SGTC_567 1080-0542 68.4 µM 1.43544131284336 0.0937608537049765 no 417 0.0755806902888307 411 5950415 SGTC_236 1509-0011 5.31 µM 1.43466499580342 0.0938828871352646 no 418 0.0756912917951923 760 3107280 SGTC_2710 st078562 53.7235 µM 1.43170567322698 0.0943491541157311 no 419 0.0761140360559387 438 17250908 SGTC_857 0438-0306 1.35 µM 1.42819232702364 0.0949049269232217 no 420 0.0766182542652016 457 4686136 SGTC_2056 5235370 200 µM 1.42654355164524 0.0951665751097185 no 421 0.0768557524697378 487 5511916 SGTC_1146 3579-1023 7 µM 1.42565671179471 0.0953075294102723 no 422 0.0769837287737671 526 X1146 SGTC_2560 caryophyllene 100 µM 1.42543766025772 0.0953423691151425 no 423 0.0770153641536206 511 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2607 solasodine 47.35 µM 1.42521064145212 0.0953784858907473 no 424 0.0770481605899046 481 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1007 4101-0031 70 µM 1.42456038483624 0.0954819919674706 no 425 0.0771421591252581 486 1146276 SGTC_1348 1493-0373 93.8 µM 1.42360435591969 0.0956343201394595 no 426 0.0772805171028788 450 3010129 SGTC_2986 9022445 71.43 µM 1.42327597487942 0.0956866837311282 no 427 0.0773280843843776 463 6459286 SGTC_1729 st035615 45.989 µM 1.42080864828041 0.0960807981081913 no 428 0.0776861979122174 461 17385451 SGTC_1762 st045503 25.4615 µM 1.41790573288745 0.0965460171698434 no 429 0.078109144213942 482 4645554 SGTC_2309 7664088 163.95 µM 1.41780887025068 0.0965615687844112 no 430 0.078123286872541 526 704922 SGTC_2028 5153890 36.43 µM 1.41356340715642 0.0972450009764664 no 431 0.0787450659096116 460 2830968 YPR165W RHO1 SGTC_2916 7875993 68.79 µM 1.41209477853633 0.097482244295186 no 432 0.0789610279960109 469 1299250 SGTC_2114 5491910 81.25 µM 1.40876651486104 0.0980214649990062 no 433 0.07945210976375 473 2849228 SGTC_1171 0368-0077 21.4 µM 1.40542634096745 0.0985648094233345 no 434 0.0799472692435851 434 3239779 SGTC_861 0443-0273 110 µM 1.40516659770181 0.0986071539437317 no 435 0.0799858720928745 472 6149169 SGTC_484 loperamide 105 µM 1.40259931541223 0.099026400352891 no 436 0.0803681780408813 353 3955 An opioid-receptor agonist. SGTC_576 1073-0113 22.7 µM 1.39736354571933 0.0998854585425426 no 437 0.0811521378075815 657 5439563 SGTC_2498 4'-Methoxychalcone 54.63 µM 1.39651988663636 0.100024389446093 no 438 0.0812789981605667 474 641818 YHR062C RPP1 SGTC_1158 4092-0494 91.8 µM 1.39516588575427 0.100247656566217 no 439 0.0814829108609002 502 1148199 SGTC_3029 9088683 49.47 µM 1.39466262375689 0.100330734296775 no 440 0.0815588004486932 468 25236615 SGTC_1568 digitonin 820 nM 1.39246983342245 0.100693303263961 no 441 0.0818900852313083 520 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2423 st077119 87.2 µM 1.38899289880938 0.10127015766783 no 442 0.0824174547080369 482 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1737 st035557 69.7 µM 1.38839546031878 0.101369519964707 no 443 0.0825083289916249 402 5716916 SGTC_3031 9088762 49.47 µM 1.38505187695724 0.101926915352146 no 444 0.0830183026141097 495 205253 SGTC_1959 st077091 55.8 µM 1.38482320738186 0.10196511727275 no 445 0.0830532664242396 516 821356 YKL052C ASK1 SGTC_1884 5633444 25 µM 1.38107838384188 0.102592216918864 no 446 0.0836274305704742 529 5724239 SGTC_13 0199-0087 65 µM 1.3800260461338 0.102768942569087 no 447 0.0837893127294017 510 4589825 SGTC_771 0250-0039 27.3 µM 1.37555349430383 0.103522514455355 no 448 0.0844799565901166 493 3005115 SGTC_3148 9097893 49.47 µM 1.37483652064058 0.103643688012015 no 449 0.0845910665054576 481 17174100 SGTC_3318 9139014 38.6185 µM 1.37438792801805 0.103719555618427 no 450 0.0846606409460491 456 16643984 SGTC_1774 st048371 48.465 µM 1.36987167430779 0.104485606330958 no 451 0.0853634816176018 521 4242727 SGTC_689 0833-0039 98 µM 1.3674941346848 0.104890529769736 no 452 0.085735237231335 510 5374726 SGTC_2964 9083345 53.42 µM 1.36701655223554 0.10497200462094 no 453 0.0858100586882926 456 17741579 SGTC_975 1335-0046 28.5 µM 1.36355174182267 0.105564468217279 no 454 0.0863543446061785 504 16486740 SGTC_1055 3448-0672 86 µM 1.36192846481049 0.105842870009217 no 455 0.0866102309811928 493 748378 SGTC_1721 st082152 9.2685 µM 1.35599053604352 0.106865781171618 no 456 0.0875510896239121 470 5296051 SGTC_2441 5730946 39.09 µM 1.35538567658052 0.106970377612892 no 457 0.0876473553643923 517 1774275 SGTC_2208 7283366 200 µM 1.35061971008525 0.107797125396787 no 458 0.0884086418424611 514 898663 SGTC_2179 6298986 200 µM 1.34912898434194 0.108056662712677 no 459 0.0886477699738071 457 738374 SGTC_1424 4048-1941 275 µM 1.34906513245288 0.108067789449855 no 460 0.0886580232388788 540 X1424 SGTC_3103 9120822 49.47 µM 1.3480578011539 0.108243434703062 no 461 0.0888198962783737 540 17141819 SGTC_1735 st034310 56.75 µM 1.34756336872489 0.10832972249959 no 462 0.08889942953729 518 871153 SGTC_3006 9075424 71.4286 µM 1.34672915498688 0.108475420746598 no 463 0.0890337394102594 497 7465181 SGTC_173 1273-0061 2.693 µM 1.34601048422076 0.108601052022298 no 464 0.0891495677176899 572 2847414 YPL266W DIM1 SGTC_793 0488-0545 106 µM 1.34592759585856 0.1086155485162 no 465 0.0891629340603754 519 292548 SGTC_189 3970-0742 2.116 µM 1.34427510818399 0.1089048455587 no 466 0.0894297208632453 485 2891807 SGTC_1944 st076371 56.9 µM 1.3434124748884 0.109056084569437 no 467 0.089569224839759 501 24208455 SGTC_1287 0971-0001 34.6 µM 1.34259736057248 0.109199131086444 no 468 0.0897011927452578 570 4665869 SGTC_980 1473-0395 201 µM 1.34123314680151 0.109438842034621 no 469 0.0899223837945609 456 768876 SGTC_59 0330-0160 1.33 µM 1.34048678003835 0.109570148680369 no 470 0.0900435697131439 673 4293482 SGTC_259 usnic acid 108.925 µM 1.33135559809054 0.111185742083241 no 471 0.0915360160717064 539 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3051 9093778 49.47 µM 1.3273308635788 0.111903234101051 no 472 0.0921996293049766 434 17217378 SGTC_2400 5203494 178.7 µM 1.32635501437651 0.112077696979556 no 473 0.0923610660627508 496 6777674 SGTC_1104 tacrolimus 29.8 µM 1.32605740503695 0.112130942420056 no 474 0.0924103417943234 567 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1683 st010134 710 nM 1.31937798909502 0.113330720121943 no 475 0.0935213882866231 536 3818134 SGTC_2424 5537928 59.2 µM 1.31928178018424 0.113348068108416 no 476 0.0935374633269024 591 5382802 SGTC_2698 st077697 67.5 µM 1.31685790718518 0.113785755830135 no 477 0.0939431290764555 509 3154499 SGTC_3243 9134147 49.47 µM 1.31505634616838 0.114111849822623 no 478 0.0942454831579117 531 24282180 SGTC_2343 7990716 14.84 µM 1.3145507080161 0.114203493059871 no 479 0.0943304727341547 549 6456862 SGTC_3276 9139060 49.47 µM 1.31344436299392 0.114404192830662 no 480 0.0945166285105273 474 4870619 SGTC_964 1287-0107 19.4 µM 1.31262938220841 0.114552197345404 no 481 0.0946539319151373 581 51516812 YPR165W RHO1 SGTC_334 1502-1024 68.5 µM 1.31106133057583 0.114837346468407 no 482 0.0949185219395718 544 3296216 SGTC_2681 menadione 3.18 µM 1.30490081402218 0.115962520162488 no 483 0.0959633120126404 538 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_884 0851-0618 334 µM 1.30439922293898 0.116054475521376 no 484 0.0960487500027752 578 9642473 SGTC_745 0469-0705 296 µM 1.3024831119355 0.116406227552056 no 485 0.0963756436980373 618 3486736 SGTC_2785 7756463 72.73 µM 1.29886605760652 0.117072291941923 no 486 0.096994949953311 530 2201551 SGTC_3258 9138477 49.47 µM 1.29682168624992 0.117449946067472 no 487 0.0973462735912883 532 4970355 SGTC_439 amiodarone 34.4 µM 1.29532840869461 0.117726341944468 no 488 0.097603481553794 609 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2385 9074692 200 µM 1.29200837550057 0.118342506987053 no 489 0.098177122047125 560 17046906 SGTC_2031 5180455 200 µM 1.29150159212477 0.118436761123363 no 490 0.0982649016930392 497 29949 SGTC_3115 9123671 49.47 µM 1.29067419338635 0.118590758936705 no 491 0.098408338453108 546 3286988 SGTC_3107 9121808 49.47 µM 1.28935300199834 0.118836956106416 no 492 0.0986376962346568 444 662681 SGTC_875 0709-0210 25.7 µM 1.28866140335401 0.118965975782219 no 493 0.0987579131200016 600 6251364 SGTC_644 1498-1197 63.3 µM 1.28824549928741 0.119043611469109 no 494 0.0988302591043194 596 6741615 SGTC_835 0312-0010 67.2 µM 1.28718901901383 0.119240982608323 no 495 0.0990142068622571 517 1626196 SGTC_1777 st045864 34.765 µM 1.28496562052281 0.119657111094234 no 496 0.0994021490474995 554 4691462 SGTC_932 2857-0803 154 µM 1.28206000625332 0.12020246458711 no 497 0.099910798572245 606 674898 SGTC_328 k915-0120 63.5 µM 1.28183068436713 0.12024558035622 no 498 0.0999510238728993 542 6624543 SGTC_775 4577-0580 57.3 µM 1.27767294704732 0.121029184136706 no 499 0.100682383908337 569 2006902 SGTC_1914 st062367 72.6 µM 1.2764001151659 0.121269789924712 no 500 0.100907057778203 537 978205 SGTC_1111 tnp00062 510.699 nM 1.27630558264295 0.121287672993664 no 501 0.100923758753239 556 676306 SGTC_490 phenamil 164 µM 1.27559467873549 0.121422216742595 no 502 0.101049418066442 434 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1738 st035555 74 µM 1.27217957509337 0.122070012694054 no 503 0.101654661462106 569 5331140 SGTC_244 nsc-207895 1.295 µM 1.27194437469855 0.122114715979066 no 504 0.101696441912195 451 42640 SGTC_1316 1272-0050 65.9 µM 1.27105233702338 0.122284365292845 no 505 0.101855015033674 568 7340392 SGTC_2327 6189656 200 µM 1.26927271375718 0.122623311318895 no 506 0.102171907375327 542 5349088 SGTC_2237 6667747 47.222 µM 1.26730128540877 0.122999557266605 no 507 0.102523790545523 528 729940 YDL015C TSC13 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.26720705203023 0.123017561896932 no 508 0.102540632437602 604 23665772 A membrane-active detergent. SGTC_1051 3253-3903 78 µM 1.26490816149102 0.123457370129111 no 509 0.102952125672146 592 5509239 SGTC_1564 D-Arginine 115 µM 1.26413732434889 0.123605087768376 no 510 0.1030903709827 560 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2364 9055074 200 µM 1.2628891337647 0.123844544354504 no 511 0.103314512788795 525 6470630 SGTC_1822 st052468 42 µM 1.26282399584969 0.123857049514316 no 512 0.103326219530697 534 2873678 SGTC_1742 st038235 28.8875 µM 1.2606958830225 0.124266090277643 no 513 0.103709218912652 595 564103 YBR002C RER2 SGTC_2328 6201408 200 µM 1.25735973741189 0.124909224821117 no 514 0.104311700819928 563 2890418 SGTC_14 0354-0009 295 µM 1.25655816360532 0.125064096263423 no 515 0.104456836007194 596 1713507 SGTC_882 0843-0131 351 µM 1.24909177511612 0.126513115358028 no 516 0.105815754287915 617 5425421 SGTC_2366 9070441 60.58 µM 1.24613460240662 0.12709024141075 no 517 0.106357491621909 598 6837235 SGTC_2936 9038235 15.59 µM 1.24580549541961 0.127154583511088 no 518 0.106417905791558 568 4749415 SGTC_386 1509-0011 3.07 µM 1.24534726117471 0.127244208395019 no 519 0.106502065115812 677 3107280 SGTC_2257 7960413 200 µM 1.24358556520389 0.12758918330015 no 520 0.106826065744053 648 2974689 YIL048W NEO1 SGTC_394 menadione 8.33 µM 1.2422944747788 0.127842416871147 no 521 0.107063966593772 610 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3169 9102970 49.47 µM 1.241634293406 0.127972039254689 no 522 0.107185761473438 575 17027839 SGTC_2289 7946404 165.07 µM 1.24039981521114 0.128214666083821 no 523 0.107413774664324 673 1246120 YPR165W RHO1 SGTC_1415 3966-0071 78.1 µM 1.2402790573942 0.128238417209813 no 524 0.10743609788752 570 2893185 SGTC_1493 4348-0038 111 µM 1.24021801728556 0.128250423982728 no 525 0.107447383000441 641 800424 SGTC_1771 st048882 4.1505 µM 1.23658609794034 0.128966238875534 no 526 0.108120391840393 595 4580403 SGTC_3244 9134489 49.47 µM 1.23487860095848 0.129303725147889 no 527 0.108437844319476 589 16584271 SGTC_262 fenpropimorph 62.5 µM 1.23361551439109 0.129553767365621 no 528 0.10867310454943 528 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_492 tmb-8 126 µM 1.23284441538175 0.129706579664952 no 529 0.108816908395177 417 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1760 st045453 10.4495 µM 1.22834613436923 0.130600513054971 no 530 0.109658529686885 636 3323419 YIL048W NEO1 SGTC_1604 st002052 72.4 µM 1.22815469413667 0.130638651822546 no 531 0.109694451243781 608 6254834 YHR062C RPP1 SGTC_804 1595-0054 20.9 µM 1.22491231864982 0.131285768418747 no 532 0.110304129263741 573 761523 Stimulates phospholipase C. SGTC_3171 9103192 49.47 µM 1.22280694698317 0.131707144068933 no 533 0.110701310484733 582 13018434 SGTC_673 1082-0474 110 µM 1.22277370048753 0.131713805602579 no 534 0.110707590690505 701 3098046 SGTC_1465 k213-0056 144 µM 1.22052176555111 0.132165562566735 no 535 0.111133571831969 586 24048857 YMR208W ERG12 SGTC_1801 st050089 28.441 µM 1.21940299176143 0.132390394680287 no 536 0.111345637487681 706 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_296 1222-0039 74.9 µM 1.2192424300457 0.132422683257139 no 537 0.111376096012645 571 5984176 SGTC_84 0443-0269 128.823 µM 1.21733749553023 0.13280617517364 no 538 0.111737916875439 622 6150058 SGTC_2162 5663267 200 µM 1.21585180019289 0.133105798297271 no 539 0.112020690997766 638 6456493 SGTC_3080 9117754 49.47 µM 1.21235586710392 0.133812664411777 no 540 0.112688093453615 671 9550191 SGTC_1253 0550-0034 176 µM 1.2112389080632 0.134039052755416 no 541 0.112901927486372 571 5969915 SGTC_620 0109-0052 432 µM 1.21026470715652 0.134236721227704 no 542 0.113088667821088 626 493037 SGTC_1258 0671-0043 57.1 µM 1.21013639375292 0.134262771340835 no 543 0.113113280076783 615 4298767 SGTC_70 0141-0289 43.283 µM 1.20751447234555 0.134795832696697 no 544 0.11361703748772 828 352408 SGTC_2957 9076800 11.52 µM 1.2069463999602 0.134911518301153 no 545 0.113726393383204 553 16459615 SGTC_2741 miltefosine 3.04 µM 1.20651098462157 0.13500023493814 no 546 0.113810263114652 498 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_378 3970-0959 8.33 µM 1.20426966060424 0.135457541665512 no 547 0.114242684566686 621 6615653 SGTC_2192 5915882 198.485 µM 1.20293831499626 0.135729683691738 no 548 0.114500095987808 560 2876149 SGTC_2069 5228469 200 µM 1.19869021958574 0.136600544924507 no 549 0.115324211223788 582 2835210 SGTC_1871 st057448 67.3 µM 1.19741897251983 0.136861892244822 no 550 0.11557164617594 653 691747 SGTC_2025 5147754 141 µM 1.19453426708678 0.137456206869969 no 551 0.116134522341449 609 315777 YLR208W SEC13 SGTC_958 1222-0007 33 µM 1.19075985896253 0.1382364778464 no 552 0.116873935668271 681 7312461 SGTC_2306 7482397 179.52 µM 1.18771559355376 0.138868004711216 no 553 0.117472739078699 637 891448 SGTC_531 3788-1495 174 µM 1.18703768001095 0.139008903577582 no 554 0.117606379076052 625 2896655 SGTC_2797 7859098 81.82 µM 1.18684660043905 0.139048635502537 no 555 0.117644066844346 630 972681 SGTC_2732 terfenadine 20 µM 1.18504615170841 0.139423389458549 no 556 0.11799959993462 578 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1902 st060212 70.5 µM 1.18475058051805 0.139484976643301 no 557 0.118058038680226 645 688944 SGTC_2825 7998094 58.44 µM 1.18423375034516 0.139592711285682 no 558 0.118160272747464 607 2987815 SGTC_503 tyrphostin 8 294 µM 1.18026452665391 0.140421992587344 no 559 0.11894751106944 621 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_995 3931-2021 34.6 µM 1.17882954783467 0.140722621192724 no 560 0.11923302798088 614 730143 SGTC_763 3453-1109 128 µM 1.17853314567975 0.140784771940154 no 561 0.119292063174809 666 1560353 SGTC_2155 5570423 76 µM 1.17709288209271 0.141087037071137 no 562 0.119579217897744 621 797402 SGTC_69 0096-0274 206.684 µM 1.17538270695497 0.141446519116097 no 563 0.119920819414783 716 6741392 SGTC_2070 5230947 200 µM 1.17523667854657 0.141477243301415 no 564 0.11995001992584 653 2835538 SGTC_2086 5274770 176.623 µM 1.17474406676799 0.141580921530576 no 565 0.120048561810145 622 689278 SGTC_949 1165-0505 146 µM 1.17196935857735 0.142165865803303 no 566 0.120604679233033 690 6244267 SGTC_287 k060-0039 29.6 µM 1.16956950631229 0.142673102863704 no 567 0.121087127396603 633 5861974 SGTC_574 1315-0397 40 µM 1.16478398915263 0.143688227280091 no 568 0.122053220693006 741 6794277 SGTC_1255 0566-0045 221 µM 1.16074872875804 0.14454798290548 no 569 0.122872049483899 659 2788469 SGTC_2015 5119600 184 µM 1.15839014774909 0.145052105662264 no 570 0.123352428954535 670 2828786 SGTC_2963 9082507 9 µM 1.15658924459237 0.145437826283211 no 571 0.123720109282308 614 16459611 SGTC_1615 st002656 86.5 µM 1.15609998011707 0.14554273687733 no 572 0.123820132089454 663 1584458 SGTC_2512 diallyl trisulfide 49.23 µM 1.15484204847041 0.145812702594597 no 573 0.124077557228919 611 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2411 st077133 39.94 µM 1.15344524202627 0.146112866461161 no 574 0.124363840424554 735 1403142 YNL221C POP1 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.1531624156835 0.146173694344714 no 575 0.124421863436328 649 7104 SGTC_100 0086-0128 49.5915 µM 1.15310465786642 0.146186118495694 no 576 0.124433715022242 710 93297 SGTC_2648 atorvastatin 78.68 µM 1.15271518694761 0.146269915203958 no 577 0.124513652917502 639 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1380 2291-0730 164 µM 1.15106995778947 0.14662425075307 no 578 0.124851728069473 623 2999191 SGTC_2674 ligustilide 100 µM 1.15094593777271 0.146650984464334 no 579 0.124877238688479 620 5319022 A signalling regulator. SGTC_1140 3229-1848 2.98 µM 1.15026772463489 0.146797237700251 no 580 0.125016809912036 667 2849525 SGTC_1443 4112-3303 14 µM 1.1490749883861 0.147054682529932 no 581 0.125262530406159 676 704433 SGTC_2556 citropten 84.59 µM 1.14364671780672 0.148230164022847 no 582 0.126385089337431 706 2775 A potential DNA crosslinker. SGTC_483 fpl-64176 144 µM 1.14330427306509 0.14830452998464 no 583 0.126456140745359 613 3423 SGTC_1216 1165-0504 9.65 µM 1.14314994127693 0.148338053130998 no 584 0.126488171038358 689 6304004 SGTC_1773 st048542 73.5835 µM 1.14027509753372 0.148963438301182 no 585 0.127085854589022 673 3237138 SGTC_1459 k035-0031 35.7 µM 1.13787952118108 0.149485908632452 no 586 0.127585396803888 583 3877128 YMR208W ERG12 SGTC_2877 9040724 71.43 µM 1.13639479327444 0.149810337965827 no 587 0.127895686958749 665 6463895 SGTC_3255 9139072 49.47 µM 1.13583422699928 0.149932949889286 no 588 0.1280129747723 663 17646060 SGTC_1925 st057770 10.1 µM 1.13550038854234 0.150006001720818 no 589 0.12808285959978 608 5989122 SGTC_3238 9133470 49.47 µM 1.13477366331776 0.150165108615235 no 590 0.128235081889892 666 3534688 SGTC_750 4073-0104 132 µM 1.13398436396067 0.150338042680514 no 591 0.128400553437643 566 22330957 SGTC_2188 6126565 140.678 µM 1.13284134163216 0.150588711962666 no 592 0.128640443401304 630 874518 SGTC_3073 9114972 49.47 µM 1.13224307897641 0.150720024228156 no 593 0.128766126722967 621 41905075 SGTC_1530 rhein 70.4 µM 1.12880429372653 0.151476279141577 no 594 0.129490200481832 724 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_499 genistein 192 µM 1.12833521124516 0.151579634601285 no 595 0.129589189136637 644 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_3033 9090887 49.47 µM 1.12691795033119 0.151892192033603 no 596 0.129888586597337 695 19325384 SGTC_142 0335-0849 62.6745 µM 1.12458693812766 0.152407195386815 no 597 0.130382055636088 791 3889043 YPR107C YTH1 SGTC_523 1934-0222 13.7 µM 1.1239307762357 0.15255237363036 no 598 0.130521196944996 697 1361595 SGTC_2804 7954240 19.48 µM 1.12294626997588 0.15277037134551 no 599 0.130730157327418 736 828705 SGTC_2563 tomatine 8.54 µM 1.12165154105654 0.153057375562756 no 600 0.131005314010421 743 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_693 4161-2696 114 µM 1.12053182195768 0.153305873151428 no 601 0.131243599938073 632 805759 SGTC_1581 himbacine 57.9 µM 1.11120878509002 0.155385294617479 no 602 0.133239245339145 718 5281825 An alkaloid muscarinic receptor antagonist. SGTC_577 r071-0003 38.6 µM 1.10917478886139 0.155841421336342 no 603 0.133677393152732 836 4568517 YMR134W ERG29 SGTC_537 1334-0398 209 µM 1.10613689541006 0.156524315706657 no 604 0.134333635683595 731 5846986 SGTC_786 4544-0069 423 µM 1.10571947218828 0.156618302869175 no 605 0.134423979585624 727 748821 YLR208W SEC13 SGTC_2803 7707263 71.43 µM 1.10323752314657 0.157177906427172 no 606 0.134962015106406 671 2199229 SGTC_1036 k216-0215 33.5 µM 1.10076656865683 0.157736335551764 no 607 0.135499132700969 715 622330 SGTC_3314 9135860 59.4275 µM 1.09998853782798 0.157912437890775 no 608 0.135668558021253 731 25252478 SGTC_3150 9097574 49.47 µM 1.09953311435916 0.158015579980295 no 609 0.135767799118783 689 17217476 SGTC_1090 efavirenz 20.7 µM 1.09651358070789 0.158700547727804 no 610 0.13642704171028 704 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1416 3966-0321 25.3 µM 1.09594238931644 0.158830338573679 no 611 0.136551993491406 727 582530 YLR208W SEC13 SGTC_1366 1683-0113 21.9 µM 1.0950144188657 0.159041348009249 no 612 0.136755159799933 669 708623 SGTC_2712 st079126 47.7 µM 1.09367554085879 0.159346116450626 no 613 0.137048652641186 659 3152970 SGTC_1497 4476-2978 41.3 µM 1.0925719009756 0.159597625042538 no 614 0.137290902755568 769 1528379 SGTC_2642 cholecalciferol 100 µM 1.09023681530198 0.160130623837537 no 615 0.137804420011956 709 9821465 A vitamin D precursor, similar to steriods. SGTC_1236 0330-0013 258 µM 1.09017756922704 0.160144162267717 no 616 0.137817466058457 694 4617066 SGTC_911 3456-4043 236 µM 1.08932011274068 0.160340185019262 no 617 0.138006373210876 735 914281 SGTC_2921 7974240 10.71 µM 1.08791079996786 0.160662707904119 no 618 0.138317243934346 700 2979074 YDR527W RBA50 SGTC_681 1642-0006 26.6 µM 1.0870962748599 0.160849306003078 no 619 0.138497131991675 703 4446530 SGTC_2853 9015042 58.44 µM 1.08498323632939 0.161334037560805 no 620 0.138964540010057 662 6457456 SGTC_373 0844-0104 25.9 µM 1.08277974885138 0.161840531873083 no 621 0.139453098187609 775 5375804 SGTC_347 4534-1311 26.2 µM 1.08238720052558 0.161930871763061 no 622 0.139540256629261 712 2862016 SGTC_735 3076-0345 636 µM 1.08172689094255 0.162082907515198 no 623 0.139686950299276 778 2888990 SGTC_1052 3253-3998 198 µM 1.07847662177926 0.162832633950299 no 624 0.140410554623477 759 5450317 SGTC_1704 st028805 70.8 µM 1.07793633574849 0.162957477789196 no 625 0.140531084245578 696 2876101 SGTC_989 1501-0895 10.3 µM 1.07521907575001 0.163586298001665 no 626 0.141138328457082 738 2830112 SGTC_3168 9103419 49.47 µM 1.07493735689192 0.163651582564964 no 627 0.141201387690536 641 16649256 SGTC_2461 5755302 26.15 µM 1.07404184159914 0.163859218539377 no 628 0.141401964411395 762 2788904 SGTC_3081 9117243 49.47 µM 1.07073594691211 0.164627209738305 no 629 0.142144087403972 722 45595589 SGTC_2466 5983409 37.09 µM 1.06959487141061 0.164892833166411 no 630 0.142400852332722 711 2879657 SGTC_143 4032-1194 15.74 µM 1.06803165316145 0.16525717473817 no 631 0.142753116913055 823 1806963 SGTC_2865 9030313 51.95 µM 1.06570577649216 0.165800233719751 no 632 0.143278332793868 687 42562754 SGTC_1806 st050005 60.3 µM 1.06522548418981 0.16591251866094 no 633 0.143386951956689 713 5194765 SGTC_2802 7925815 54.55 µM 1.06400901724377 0.166197129713118 no 634 0.143662307327318 733 1262923 SGTC_2739 tacrine 100.86 µM 1.06346044792658 0.166325579010282 no 635 0.143786596305744 685 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_3334 9142812 21.919 µM 1.06211174129596 0.166641655562202 no 636 0.144092480229538 715 45283678 SGTC_878 0828-0289 13.7 µM 1.05903694052379 0.167363699673132 no 637 0.14479147826957 761 745350 YLR208W SEC13 SGTC_1665 st014639 11.4 µM 1.05854044159812 0.167480479462527 no 638 0.144904561719549 791 981133 YIL048W NEO1 SGTC_787 4152-0075 138 µM 1.05768364478621 0.16768212710272 no 639 0.145099847049709 719 9566539 SGTC_921 1561-0023 372 µM 1.0560701587829 0.168062286273017 no 640 0.145468081350847 763 24050882 SGTC_1573 oleylamine 1.06 µM 1.05441266181348 0.168453392091057 no 641 0.145847013876419 738 5356789 An amine of the fatty acid oleic acid. SGTC_540 1187-0821 17.3 µM 1.05377014289195 0.168605159232931 no 642 0.145994083101174 728 847520 SGTC_2544 sphondin 68.51 µM 1.05366508348854 0.168629983304606 no 643 0.146018140124874 704 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_3052 9092717 49.47 µM 1.05275666267148 0.168844728447215 no 644 0.146226265908336 713 25237534 SGTC_2618 avocadyne 43.43 µM 1.0450434390835 0.170675162557354 no 645 0.148001446681506 743 3015189 SGTC_2359 9039622 200 µM 1.04442691632775 0.170822016517947 no 646 0.148143957926038 799 6463596 SGTC_1677 st019204 53.9 µM 1.04411608057324 0.170896087359185 no 647 0.148215843430542 717 3945625 SGTC_2553 4-methylesculetin 85.09 µM 1.04340258766269 0.17106618740316 no 648 0.148380937791596 760 5319502 SGTC_204 PMA1.184 62.41 µM 1.04278771830838 0.171212861972725 no 649 0.148523310386982 813 2252213 YGL008C PMA1 SGTC_563 tetrahydrosecaminediol 614 µM 1.04217861217702 0.171358241011972 no 650 0.148664438547485 798 334274 A psychoactive constituent of the cannabis plant. SGTC_448 monastrol 171 µM 1.04030985363979 0.171804761155066 no 651 0.149097983855842 755 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2723 salbutamol 83.58 µM 1.03967789942668 0.171955927931902 no 652 0.149244785861771 669 9884233 β2-adrenoceptor agonist SGTC_1591 genipin 88.4 µM 1.03666282008645 0.172678319407322 no 653 0.149946512604102 750 442424 A DNA cross-linking agent. SGTC_535 2293-4129 48.2 µM 1.03404367864322 0.173307414926452 no 654 0.150557872101446 840 396118 YIL048W NEO1 SGTC_1534 6-azauridine 81.6 µM 1.03339055259203 0.173464517282929 no 655 0.150710582922588 816 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_647 0140-0236 81 µM 1.03003042304641 0.174274191954213 no 656 0.15149786219249 861 990837 SGTC_2272 7805186 180 µM 1.02842541578165 0.174661789162683 no 657 0.151874879079659 784 2956062 YPR165W RHO1 SGTC_3291 9121177 71.43 µM 1.02813680226909 0.174731545175551 no 658 0.15194274058307 680 17015612 SGTC_1780 st038448 24.544 µM 1.02664809124259 0.175091637804315 no 659 0.152293100091326 771 728868 YDL195W SEC31 SGTC_927 2425-1185 123 µM 1.02483432269488 0.175530991714843 no 660 0.152720684190576 769 730375 SGTC_764 1951-2361 146 µM 1.02335567798843 0.175889684230735 no 661 0.153069853661611 752 5438930 SGTC_2195 6536160 144.242 µM 1.02281227159297 0.176021621377177 no 662 0.153198307361069 700 3834386 SGTC_47 0149-0135 24.25 µM 1.01436412795302 0.178080855094519 no 663 0.155204517316261 761 5239155 SGTC_1053 3366-3204 134 µM 1.01045004523593 0.179040039508824 no 664 0.156139860692907 761 3632071 YPR165W RHO1 SGTC_1617 st002906 78 µM 1.01037626775334 0.179058150562782 no 665 0.156157526794947 818 5150859 SGTC_111 0083-0039 52.457 µM 1.00856332549887 0.179503557619388 no 666 0.15659205167034 682 759313 SGTC_1323 1348-1351 11.2 µM 1.0049757830024 0.180387002312148 no 667 0.157454255506956 762 6989654 SGTC_1183 1254-0324 198 µM 1.00422842399982 0.180571384803766 no 668 0.157634262272401 807 5799357 SGTC_2218 6965428 192.983 µM 1.00267975667919 0.180953835812333 no 669 0.158007700072703 798 675684 SGTC_906 1165-0455 526 µM 1.00106760471467 0.181352503494282 no 670 0.158397062741797 773 3252859 SGTC_1558 st069300 45.6 µM 0.999675661205597 0.181697158058656 no 671 0.158733747151662 738 24208000 SGTC_1865 st057639 52.2 µM 0.997687350050475 0.182190187546417 no 672 0.159215494586762 806 688818 SGTC_1089 terbinafine 2.25 µM 0.994855156177492 0.182893911814717 no 673 0.159903357916705 805 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2058 5236698 133 µM 0.994719591809695 0.182927638415808 no 674 0.159936331511178 778 766665 SGTC_1687 st020778 55.3625 µM 0.994429536499279 0.182999813331797 no 675 0.160006897184684 906 4259299 SGTC_2597 laccaic acid a 100 µM 0.98789198162574 0.184631274234976 no 676 0.16160277642677 810 5491415 A textile dye. SGTC_397 arbidol 50 µM 0.987039185794069 0.184844756104972 no 677 0.161811714413164 870 131410 A RNA synthesis inhibitor. SGTC_3269 9137823 49.47 µM 0.985489594026796 0.185233060585007 no 678 0.162191820177021 742 17682936 SGTC_2339 9000433 200 µM 0.9849445723873 0.18536975517153 no 679 0.162325648875862 712 2988954 SGTC_2118 5526350 200 µM 0.982415690070218 0.186004832610027 no 680 0.162947549847257 844 743594 SGTC_2920 7982904 15.77 µM 0.976953122531628 0.187381242506022 no 681 0.164296180266469 760 6456808 SGTC_752 1896-0090 130 µM 0.975579981178026 0.187728222396175 no 682 0.164636324459825 845 772567 SGTC_1335 1486-0900 202 µM 0.974807052109566 0.187923708752345 no 683 0.16482798917131 844 X1335 SGTC_2067 5224629 34.075 µM 0.972083151648938 0.188613628978128 no 684 0.165504591631461 795 2835000 SGTC_1943 st076331 65.2 µM 0.97186059926542 0.188670066843019 no 685 0.165559951742041 858 24208415 SGTC_2413 inermin 26.06 µM 0.971404405460501 0.188785787218162 no 686 0.165673467803379 851 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1873 rapamycin 2 nM 0.971266434233815 0.188820794294835 no 687 0.165707809504059 863 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1283 0922-0125 16.4 µM 0.969898683352102 0.189168046485027 no 688 0.166048498214634 890 3360884 SGTC_3192 9110362 49.47 µM 0.966519074866079 0.190027765115326 no 689 0.166892253384532 866 16649480 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.964861671888312 0.190450258300597 no 690 0.167307050571852 798 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1966 st070145 16.1 µM 0.962759433836734 0.190986974702161 no 691 0.167834131372059 812 3748532 SGTC_213 1246-0773 967 nM 0.962049442491075 0.191168449934384 no 692 0.168012384230392 866 6251622 SGTC_2027 5150920 200 µM 0.961643441773438 0.191272272041523 no 693 0.168114370898951 825 786715 SGTC_2145 5634607 200 µM 0.959592907990887 0.191797160446694 no 694 0.168630069884686 790 308662 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.958261609945285 0.192138413112441 no 695 0.168965428494476 885 4174840 SGTC_1302 1159-0335 255 µM 0.957814307585593 0.192253153797537 no 696 0.16907820160026 821 649284 SGTC_1635 st007035 42.4 µM 0.955072358437963 0.192957426025764 no 697 0.169770553138383 958 3716403 SGTC_1495 4469-0029 237 µM 0.951345380589807 0.193917226310353 no 698 0.170714538628407 930 793680 SGTC_306 1672-3436 11.6 µM 0.950787153868452 0.194061235311914 no 699 0.170856217514846 866 6797378 SGTC_549 1661-1316 519 µM 0.949816169239844 0.194311881057449 no 700 0.171102834256095 894 2857282 SGTC_2789 5281112 71.43 µM 0.949786746122742 0.194319479288638 no 701 0.171110310875388 822 765948 SGTC_392 N-ethylmaleimide 8.33 µM 0.946143407491059 0.195261733376718 no 702 0.172037723202576 824 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_860 0443-0016 25.1 µM 0.938964272958103 0.197126535310408 no 703 0.173874543896732 922 5337942 SGTC_3312 9133330 71.43 µM 0.936680037777746 0.197722124911632 no 704 0.17446158378904 932 17617324 SGTC_2066 5222451 176 µM 0.935130295866046 0.19812682182114 no 705 0.17486057759833 931 2281147 SGTC_2892 9047358 58.44 µM 0.934626578556607 0.198258469304574 no 706 0.174990388376299 800 6466771 SGTC_900 1112-0045 141 µM 0.93428892660751 0.198346744839008 no 707 0.175077437399851 756 56211 YIL048W NEO1 SGTC_82 0054-0107 293.755 µM 0.934006797539819 0.198420522689329 no 708 0.175150193300064 888 3104697 SGTC_2357 9067248 200 µM 0.933986900423215 0.198425726487822 no 709 0.175155325124501 825 9150235 SGTC_2463 5473429 200 µM 0.932149711992569 0.198906570879119 no 710 0.175629579991714 847 5399405 SGTC_1439 4092-1168 46 µM 0.930730942262936 0.199278383366005 no 711 0.175996379830795 889 2886240 SGTC_1221 2958-7315 257 µM 0.929266709092362 0.199662548871193 no 712 0.176375441723941 834 4562705 SGTC_1770 st043884 66.3 µM 0.92851905868475 0.199858878913191 no 713 0.176569193138266 898 670149 SGTC_1838 st055369 84.5 µM 0.928427932047766 0.199882816343639 no 714 0.176592817538952 869 676036 SGTC_2132 5317594 122.667 µM 0.927646888953588 0.200088053902625 no 715 0.176795383399744 825 794577 SGTC_544 k015-0020 52.4 µM 0.924550959896779 0.200902827958138 no 716 0.177599766075664 859 3008304 SGTC_3321 9137793 26.8275 µM 0.923682954874415 0.201131622824787 no 717 0.177825704586776 883 4904192 SGTC_831 k061-1017 217 µM 0.923117623069789 0.201280720949024 no 718 0.177972955826488 1016 1240153 SGTC_914 3820-6779 408 µM 0.922260730325436 0.201506840364248 no 719 0.178196296114184 876 2893481 SGTC_1995 st072814 61.1 µM 0.918082713635424 0.202611526414941 no 720 0.179287782052695 845 5769371 SGTC_1004 4084-0029 199 µM 0.91793309885635 0.202651152237644 no 721 0.17932694597838 938 716894 YLR208W SEC13 SGTC_1633 st005664 67.9 µM 0.913636080147316 0.203791203310113 no 722 0.180454050635542 907 2063822 SGTC_2880 9042983 58.44 µM 0.911266128583424 0.204421612570712 no 723 0.181077584274466 871 6464714 SGTC_2759 disulfiram 3.38 µM 0.91040598027094 0.204650699591509 no 724 0.181304222524303 856 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.909905338462245 0.204784107981069 no 725 0.181436217082445 1096 16725076 SGTC_61 0978-8327 98.565 µM 0.909358023487375 0.204930012754473 no 726 0.18158058586651 920 6150059 YHR072W ERG7 SGTC_1047 2043-3044 82 µM 0.905605141366237 0.205932130399111 no 727 0.182572443261019 937 669592 SGTC_2874 9043904 71.43 µM 0.903830346818465 0.206407057573992 no 728 0.183042683773367 818 4463428 SGTC_918 glabranin 770.725 nM 0.902083656703115 0.206875097192148 no 729 0.183506214967121 904 124049 Also referred to as licorice root. SGTC_110 0850-0284 111.64 µM 0.900662080274859 0.207256483254379 no 730 0.183884008041158 774 3906265 SGTC_684 1140-0066 328 µM 0.898766481812726 0.207765688146973 no 731 0.184388528515965 930 6813534 SGTC_1217 1183-1422 255 µM 0.896168756136455 0.208464700775465 no 732 0.185081319920169 969 2849664 SGTC_227 fluconazole 33.516 µM 0.895379873595621 0.208677252553301 no 733 0.185292027878059 938 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2934 9036370 36.88 µM 0.894847973502612 0.208820636593773 no 734 0.185434180697618 938 6462800 SGTC_86 0417-1630 471.922 µM 0.894125804511562 0.209015404209965 no 735 0.1856272920999 1013 3634867 SGTC_1222 0366-0074 1.18 µM 0.891159398066238 0.209816560015042 no 736 0.186421831466481 983 286520 SGTC_1016 4226-1401 38 µM 0.890285854928308 0.21005282685761 no 737 0.186656207211403 920 2901613 SGTC_2394 5221648 200 µM 0.889349604893273 0.210306227474021 no 738 0.186907609961497 1014 788586 SGTC_1134 3477-0009 42.5 µM 0.888283032429882 0.210595119091226 no 739 0.187194262184182 951 3973534 SGTC_88 0180-0332 8.668 µM 0.886203173049483 0.211159138730454 no 740 0.18775402706036 997 3101745 SGTC_529 4076-0302 30.3 µM 0.884342157330085 0.211664561578155 no 741 0.188255768683912 894 5816522 SGTC_355 1311-2252 105 µM 0.883662618969656 0.211849289936328 no 742 0.188439182527016 885 5338538 SGTC_715 0868-0130 184 µM 0.881735179724517 0.212373765452788 no 743 0.188960015991142 930 2876258 SGTC_3352 9151559 45.5865 µM 0.880919100795082 0.212596057132173 no 744 0.18918080416975 895 17159339 SGTC_1715 st032160 10.2275 µM 0.880716735604398 0.212651200390334 no 745 0.189235578151944 897 5289825 SGTC_698 k064-0052 127 µM 0.879932566357071 0.21286496051808 no 746 0.189447920663013 952 5088751 SGTC_2940 9060638 45.86 µM 0.879798852720578 0.212901422615267 no 747 0.189484143149706 903 4027022 SGTC_500 h-89 112 µM 0.877280790848977 0.213588748105065 no 748 0.190167071591269 989 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2675 theaflavin digallate 100 µM 0.876847440935219 0.213707164752954 no 749 0.190284753612272 952 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_909 3448-9333 149 µM 0.876747677725324 0.213734431335471 no 750 0.190311851992711 866 3344074 SGTC_1147 3809-1045 12.3 µM 0.874457274522218 0.214360985387468 no 751 0.190934639088438 909 325925 SGTC_897 1000-0139 31.4 µM 0.871666056537326 0.215125982678432 no 752 0.191695291413043 942 6151020 SGTC_3113 9123498 49.47 µM 0.870600335259052 0.215418485602931 no 753 0.191986206677807 1007 8897275 SGTC_3026 9090633 49.47 µM 0.870322030126765 0.215494908527125 no 754 0.192062221491678 970 25236842 SGTC_2137 5261020 140 µM 0.867571906115977 0.216250940927428 no 755 0.192814365839471 926 763655 SGTC_2924 9010168 62.78 µM 0.867323346868397 0.216319347558977 no 756 0.192882434030488 946 2993929 SGTC_3350 9150499 3.57 µM 0.866442239321467 0.216561940320926 no 757 0.193123844399757 998 4910996 YPR165W RHO1 SGTC_924 2046-0044 21.3 µM 0.866361111640034 0.216584284878471 no 758 0.193146081448556 997 3623589 SGTC_301 4119-0100 24.5 µM 0.860600890681011 0.218174197373507 no 759 0.19472894761064 958 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_3235 9132602 49.47 µM 0.858772240322394 0.218680337016515 no 760 0.195233092849942 977 4912240 SGTC_1174 0739-0097 51.1 µM 0.856530855989335 0.219301635385751 no 761 0.195852106473987 952 728447 SGTC_903 1134-0042 114 µM 0.855169443304059 0.219679505574727 no 762 0.196228674942353 944 701009 SGTC_91 0417-1751 58.384 µM 0.852780395331715 0.220343506399555 no 763 0.196890548838533 1115 6795624 SGTC_1196 1588-0294 184 µM 0.851111451398609 0.220808046692642 no 764 0.197353722395449 915 6144269 SGTC_1293 1000-1278 195 µM 0.851059176222834 0.220822606218928 no 765 0.19736824069612 986 678847 SGTC_2995 9067767 71.4286 µM 0.849647989277133 0.221215853469111 no 766 0.197760411422198 907 11673567 SGTC_3084 9116877 49.47 µM 0.844997110267621 0.222514718937744 no 767 0.199056226235768 917 27241325 SGTC_2696 st077691 74.316 µM 0.841201055653743 0.223578070507341 no 768 0.200117654615616 899 757133 SGTC_1463 k081-0032 34.1 µM 0.839451640599983 0.224069088173982 no 769 0.200607957827599 854 977755 SGTC_1667 st014849 34.6 µM 0.83816610513362 0.224430296388424 no 770 0.200968710245355 1010 5348460 SGTC_1082 camptothecin 424.86 nM 0.837036578774536 0.22474794190804 no 771 0.201286003715676 970 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2600 tangeritin 87.95 µM 0.835848842359193 0.225082232087971 no 772 0.201619972606639 940 68077 A bioactive flavone. SGTC_2029 5175081 200 µM 0.835600865729806 0.225152061012429 no 773 0.201689740781313 1051 1380876 SGTC_1381 2324-0066 62.1 µM 0.835529524508732 0.225172152600935 no 774 0.201709815297618 926 10885928 SGTC_1461 k072-0203 53.8 µM 0.835122614365639 0.225286768753167 no 775 0.201824337536021 944 5418714 SGTC_2277 7947813 106.88 µM 0.834792652064923 0.225379734925324 no 776 0.201917231878829 947 1246798 SGTC_2455 5377712 9.75 µM 0.833457620446311 0.225756098876574 no 777 0.202293344765051 893 2243908 SGTC_326 k292-0812 17.5 µM 0.833055128048846 0.2258696367815 no 778 0.202406819428277 997 3579357 SGTC_3332 9141069 11.198 µM 0.83266275662175 0.225980350767443 no 779 0.202517477317759 947 17332883 SGTC_2816 7982706 58.44 µM 0.832503580521628 0.226025273641702 no 780 0.202562378998968 959 2981853 SGTC_2241 6772625 37.8075 µM 0.831486418759173 0.226312457450009 no 781 0.202849448702487 999 2285411 SGTC_615 k087-0205 167 µM 0.830000072198315 0.22673248055761 no 782 0.203269371418004 972 9642773 SGTC_1395 3486-0190 4.35 µM 0.829782522754029 0.226793994214856 no 783 0.20333087699405 1035 6748079 SGTC_2295 7971645 200 µM 0.829117462791338 0.226982103042011 no 784 0.203518971592936 964 2978226 YKL099C UTP11 SGTC_455 paf C-16 10 µM 0.828853417307592 0.227056811357465 no 785 0.203593678638902 944 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1896 st058441 89 µM 0.82806559600309 0.227279797760732 no 786 0.203816676052863 909 688759 SGTC_2840 9008771 71.43 µM 0.827172452847958 0.227532743839076 no 787 0.204069661434674 970 2992978 SGTC_1942 st076330 65.2 µM 0.82612033173082 0.227830917155152 no 788 0.204367917632165 1053 24208414 SGTC_2705 st078069 42.8 µM 0.825506427660168 0.228005000378006 no 789 0.204542067505935 933 1530061 SGTC_3290 9121031 71.43 µM 0.82293043346283 0.228736283595523 no 790 0.205273777463153 963 17014854 SGTC_1241 0364-0022 50.8 µM 0.822904403228139 0.228743679873708 no 791 0.205281179266479 1000 4563895 SGTC_1 0258-0098 57.368 µM 0.822373205641631 0.228894644646448 no 792 0.205432262094504 896 6790032 YDR047W HEM12 SGTC_1254 0550-0035 264 µM 0.820865493862583 0.229323436284165 no 793 0.205861443918126 1039 15121435 SGTC_2321 7390090 138.78 µM 0.818792280306599 0.229913790684764 no 794 0.20645246803945 942 649046 SGTC_1779 st039427 55 µM 0.81869197384383 0.229942374840131 no 795 0.206481088511239 1092 1124498 SGTC_1748 st037455 53.6035 µM 0.817822744874786 0.230190160770891 no 796 0.206729204288134 993 580690 SGTC_2779 methotrexate 400 µM 0.817109006442742 0.230393733562813 no 797 0.206933068222797 1110 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1696 st025591 34.7925 µM 0.817070077727442 0.230404839722131 no 798 0.206944190788242 1029 2787147 SGTC_817 1391-0715 46 µM 0.815547034498355 0.23083959086359 no 799 0.207379626576552 964 1353946 SGTC_3250 9135583 49.47 µM 0.814189406834609 0.231227510173593 no 800 0.207768226532323 1011 7699353 SGTC_2267 7931562 200 µM 0.813979424295471 0.231287541617115 no 801 0.207828369175599 916 934880 SGTC_885 0865-0106 16.8 µM 0.809537137680588 0.232559572590014 no 802 0.209103125038529 1052 2793380 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.809417321502733 0.23259393525807 no 803 0.209137571059564 964 521171 SGTC_2123 5259487 200 µM 0.809325346369779 0.232620315171567 no 804 0.209164015309345 1045 2173474 SGTC_1000 4048-0884 8.67 µM 0.807763380414217 0.233068565428976 no 805 0.209613404799263 985 13040088 SGTC_2968 9090663 33.37 µM 0.806453615676834 0.233444808831047 no 806 0.209990671432849 974 25236811 SGTC_398 bronopol 33.3 µM 0.805292870402881 0.233778526269171 no 807 0.210325347520164 1014 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2639 lactacystin 53 µM 0.802534196855079 0.234572712383754 no 808 0.211122007620861 1034 3870 A proteasome inhibitor. SGTC_954 1189-0853 2.85 µM 0.801746042922393 0.234799885387617 no 809 0.211349938059434 1080 2828194 SGTC_1840 st055363 71 µM 0.801086587751107 0.234990056404074 no 810 0.211540760125225 973 676033 SGTC_1406 3909-7906 11.9 µM 0.800193838639842 0.235247639312189 no 811 0.211799249520843 1053 X1406 SGTC_2826 7992541 19.48 µM 0.799158499630214 0.235546558497202 no 812 0.212099256176686 1094 2985066 SGTC_3046 9092212 49.47 µM 0.796641268056826 0.236274197467176 no 813 0.2128297014073 1029 25236637 SGTC_209 4077-0173 175.592 µM 0.796127362794218 0.236422900554771 no 814 0.212979005692835 953 15993494 SGTC_1394 3474-0001 65.7 µM 0.795189586565713 0.236694387225498 no 815 0.213251614167585 953 5017666 YIL048W NEO1 SGTC_1303 1160-0052 261 µM 0.793993295283643 0.237040962891108 no 816 0.213599667289588 1094 3562476 SGTC_3038 9091290 49.47 µM 0.793555913402248 0.237167745694937 no 817 0.213727003267232 1037 25236843 SGTC_2868 9035608 32.47 µM 0.792821267263501 0.237380779564148 no 818 0.213940981935259 1082 6462614 SGTC_1819 st053448 58.6 µM 0.791953818864141 0.237632458861562 no 819 0.214193802112462 1035 2857616 SGTC_2859 9028643 45.46 µM 0.791569024058873 0.237744149121365 no 820 0.214306007230696 1028 17151580 SGTC_2623 humulene 100 µM 0.790091177962253 0.238173375206507 no 821 0.214737260812946 957 6187145 An anti-inflammatory. SGTC_1647 st011722 22.4 µM 0.789926738897357 0.238221161177384 no 822 0.214785277301554 1023 2854783 SGTC_315 k915-0449 187 µM 0.788979423163884 0.23849655327049 no 823 0.215062016574667 1088 20970215 YNL149C PGA2 SGTC_2120 5538279 151.968 µM 0.78855835473138 0.238619017086023 no 824 0.215185089694866 1037 2058197 SGTC_36 0335-0881 14.2 µM 0.788000397757853 0.238781346654905 no 825 0.215348236611747 1062 23828853 SGTC_3209 9113616 49.47 µM 0.78783479510919 0.238829537990604 no 826 0.215396672722871 1087 16649353 SGTC_412 gemfibrozil 100 µM 0.786984794450903 0.239076976845246 no 827 0.215645383699744 1026 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2314 7727897 200 µM 0.785734200477722 0.239441284751888 no 828 0.216011611193621 1070 900724 SGTC_2929 9013348 24.6 µM 0.784356658642187 0.239842924196872 no 829 0.216415431173547 1029 2995952 SGTC_2773 thioridazine 9.09 µM 0.783227036881007 0.240172553520798 no 830 0.216746900324733 1116 5452 An antipsychotic. SGTC_1947 st076332 61.6 µM 0.782552738848595 0.240369434707866 no 831 0.216944901975718 1064 24208416 SGTC_1315 1237-0019 3.69 µM 0.780485251349329 0.240973646301173 no 832 0.21755265270198 1081 825140 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.779338542292502 0.241309121362757 no 833 0.217890158129293 1020 2374 Ca(2+)-ATPase inhibitor. SGTC_1922 5578187 25 µM 0.77684762826547 0.242038723376813 no 834 0.21862433644889 1053 1350412 SGTC_3249 9135183 49.47 µM 0.776798366071655 0.242053164590088 no 835 0.218638870458733 1097 4902779 SGTC_569 4130-2812 160 µM 0.776433544280529 0.242160126648833 no 836 0.21874652251064 967 743552 SGTC_1571 st070080 73.4 µM 0.774602379254752 0.242697392604867 no 837 0.219287325485725 1072 4315245 SGTC_1626 st003712 1.76 µM 0.773598807724901 0.242992115175438 no 838 0.219584038690452 1006 24207035 SGTC_2524 avocatin b 10.57 µM 0.77347387396646 0.243028818481058 no 839 0.219620992394808 1033 6710748 SGTC_1180 1193-0155 285 µM 0.771798142812513 0.24352140806609 no 840 0.220116995941727 1066 2921347 SGTC_1522 st012842 45.6 µM 0.768504671056901 0.244491110132213 no 841 0.221093708324311 966 3491067 YOR116C RPO31 SGTC_880 0833-0487 87.2 µM 0.766730248542223 0.245014417179892 no 842 0.2216209575948 1087 76075 SGTC_2663 amphotericin b 100 µM 0.765331585461086 0.245427330746189 no 843 0.222037060196072 1088 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2173 5763948 167 µM 0.763591547809439 0.245941546499695 no 844 0.222555343857747 1131 2867177 SGTC_1474 0330-0125 5.35 µM 0.763277864547826 0.246034307612764 no 845 0.222648850170081 1123 X1474 SGTC_323 4013-0906 34.3 µM 0.762848822951234 0.246161212400402 no 846 0.222776780076303 1116 2910086 SGTC_1063 disulfiram 1.84 µM 0.762713736903248 0.246201176318649 no 847 0.222817068162358 1108 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1912 st060209 90.8 µM 0.762614428241736 0.246230558057335 no 848 0.222846688642185 1064 688787 SGTC_1652 st011932 78 µM 0.762305073425354 0.24632209668867 no 849 0.222938973301263 1065 1551076 SGTC_566 0958-0068 16.5 µM 0.762134584257054 0.246372552527736 no 850 0.22298984179245 1058 6815365 SGTC_427 1354-0053 47.3 µM 0.761909268506818 0.246439242652423 no 851 0.223057078914778 1068 6813657 SGTC_475 α-linolenic acid 10 µM 0.760275583998347 0.24692307829057 no 852 0.223544936610824 1196 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2142 5622915 118.518 µM 0.760032380995937 0.246995149280709 no 853 0.223617614770526 1088 5322196 SGTC_1458 k015-0034 6.33 µM 0.759996070604215 0.247005910499496 no 854 0.223628466827325 1094 3598957 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.756986172531429 0.247898817975908 no 855 0.224529073313627 1090 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3134 9127454 49.47 µM 0.756559556890192 0.248025515763124 no 856 0.224656889392833 1141 24262820 SGTC_3028 9087778 49.47 µM 0.750553159314135 0.249812977953567 no 857 0.226460809959003 1105 17217395 SGTC_1001 4048-4355 44.4 µM 0.750294057575263 0.249890238409287 no 858 0.226538810399047 1093 21824233 SGTC_1623 st003709 20.3 µM 0.750033900110754 0.249967826426266 no 859 0.226617143914344 1093 16192618 SGTC_2102 5377816 72.7585 µM 0.749820315750704 0.250031534276223 no 860 0.226681465676167 1144 1379702 SGTC_3101 9120531 49.47 µM 0.749193486156162 0.250218554466596 no 861 0.226870297327982 1123 24824904 SGTC_3063 1327-0034 4 µM 0.747652793685514 0.250678548853219 no 862 0.227334805929422 1055 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1116 jasmonic acid  1.58368 µM 0.745205282897695 0.251410205858912 no 863 0.228073814843882 1131 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2138 5575593 77.673 µM 0.743483491484432 0.251925592371388 no 864 0.228594506312445 1135 762213 SGTC_826 1683-5028 118 µM 0.742345058388581 0.252266667310024 no 865 0.228939149192711 1112 722377 SGTC_1399 3562-5772 25 µM 0.7411101700567 0.252636915383148 no 866 0.229313321848284 1054 23847490 SGTC_2728 chlorpromazine 9.18 µM 0.740698877040752 0.252760294048523 no 867 0.229438020195906 1104 2726 A thorazine and dopamine antagonist. SGTC_167 3672-0051 66.205 µM 0.739596350996671 0.253091183539825 no 868 0.229772478235127 1099 3237971 SGTC_342 k048-0088 23.3 µM 0.738252825528504 0.253494709454242 no 869 0.230180413722835 1123 6820570 SGTC_2922 7999257 32.47 µM 0.737376977413408 0.25375795106697 no 870 0.230446566030234 1094 2988377 SGTC_1336 1486-0901 104 µM 0.735152769608445 0.254427095102475 no 871 0.231123229784225 1131 5006114 SGTC_1600 coumarin 106 71.1 µM 0.734359076485157 0.254666098171141 no 872 0.231364960705849 1139 100336 A hepatotoxic, DNA x-linker. SGTC_1109 tnp00067 928.257 nM 0.733998424395448 0.254774739382521 no 873 0.231474849182044 1125 676295 SGTC_2318 6029776 164 µM 0.733879480769115 0.254810574744882 no 874 0.231511096954359 1121 818325 SGTC_1077 5-fluorocytosine 377 nM 0.733109643314108 0.25504257533431 no 875 0.23174577949601 1097 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1041 0206-0046 107 µM 0.732608803398931 0.255193569304805 no 876 0.231898530116591 1109 50494 SGTC_119 0121-0043 24.815 µM 0.731521884182945 0.255521416072824 no 877 0.232230221237183 1234 1092378 SGTC_1519 esterone 74 µM 0.730531756471049 0.255820259081969 no 878 0.232532604495022 1130 698 A steroid. SGTC_3132 9126706 49.47 µM 0.730467042397263 0.255839797607348 no 879 0.232552375678189 1150 850858 SGTC_1268 0828-0275 2.46 µM 0.730460984254941 0.255841626726435 no 880 0.232554226585274 1171 745337 SGTC_2504 purpurogallin 52.29 µM 0.729880819269658 0.2560168260457 no 881 0.232731518783315 1066 5281571 An antioxidant. SGTC_596 1155-0152 116 µM 0.728510598067272 0.256430856369426 no 882 0.233150541739636 1157 280313 SGTC_2112 5488546 200 µM 0.728310761680295 0.256491268695145 no 883 0.23321168804086 1142 600757 SGTC_1736 st036774 51 µM 0.725503693314828 0.257340653478361 no 884 0.234071539957683 1186 1272247 SGTC_350 k064-0020 19.8 µM 0.72541938998794 0.257366185231538 no 885 0.23409739060318 1165 2790705 SGTC_2474 5321570 43.32 µM 0.725392266167712 0.25737440011823 no 886 0.234105708146824 1148 2841384 SGTC_2380 9035439 200 µM 0.72425892928062 0.257717771235451 no 887 0.234453393156556 1221 6462575 SGTC_3127 9126946 49.47 µM 0.723234017763708 0.25802849697927 no 888 0.234768061287178 1054 27243249 SGTC_1961 st076550 68.7 µM 0.723206695666423 0.258036782966149 no 889 0.234776452905793 1108 1579337 SGTC_157 1348-1695 65.819 µM 0.722290495062344 0.258314719491424 no 890 0.235057947719834 1168 5380510 SGTC_2060 5238662 140 µM 0.722244404150797 0.25832870562271 no 891 0.235072113682849 1110 790130 SGTC_1390 3413-2614 145 µM 0.721059853133079 0.258688288217146 no 892 0.235436345175808 1195 3421432 SGTC_963 1269-2853 151 µM 0.720963655665364 0.25871750131489 no 893 0.235465938107121 1145 3668223 SGTC_2396 5342950 42.78 µM 0.720475772036492 0.258865687345811 no 894 0.23561605584735 1153 1886677 SGTC_1213 1315-0166 115 µM 0.719206448969402 0.259251427446945 no 895 0.236006863241904 1113 768401 SGTC_2234 tolnaftate 200 µM 0.718981086566004 0.259319944846726 no 896 0.236076286596369 1142 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_970 1315-0089 19.5 µM 0.718532514164841 0.259456353088041 no 897 0.236214503731525 1127 6811083 YLR033W RSC58 SGTC_2197 6588183 93.1375 µM 0.717838182346054 0.25966756838637 no 898 0.236428533761281 1160 884136 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.717713224603518 0.259705589873964 no 899 0.236467063720748 1179 279621 SGTC_491 tetrandrine 80.3 µM 0.717536041096014 0.259759507269216 no 900 0.236521703100867 1133 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_271 rotenone 740 µM 0.71696564143215 0.259933120570735 no 901 0.236697648612722 1212 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2116 5511452 16.8835 µM 0.716779103535396 0.259989910341548 no 902 0.236755203720505 1151 870744 SGTC_2444 5485484 36.41 µM 0.714841358527867 0.260580217464675 no 903 0.237353537917569 1184 6790631 SGTC_605 1315-0399 119 µM 0.714088484262169 0.260809756140138 no 904 0.237586233160998 1199 24020461 SGTC_1939 st074455 53.6 µM 0.710705271041049 0.26184252331318 no 905 0.23863344630941 1179 1644229 SGTC_1072 oxiconazole 14.9 nM 0.70931337290572 0.26226802539841 no 906 0.23906501576802 1169 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1334 1486-0610 236 µM 0.709166689934845 0.262312886880004 no 907 0.239110520865508 1164 3742339 SGTC_2640 pentamidine 10.38 µM 0.709018015815909 0.262358361344153 no 908 0.239156648502595 1197 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1860 st056228 74.6 µM 0.708545365215388 0.262502956243935 no 909 0.239303325393594 1165 688679 SGTC_798 1287-0182 476 µM 0.707991791607129 0.26267235924151 no 910 0.239475177455424 1211 1649755 SGTC_866 0495-0101 262 µM 0.706526132082397 0.263121146069927 no 911 0.239930503803416 1153 635694 SGTC_1945 st075991 56.6 µM 0.706404964342207 0.263158265313325 no 912 0.239968167269275 1107 1084980 SGTC_829 1635-0120 117 µM 0.705672614254847 0.263382674714921 no 913 0.240195877688513 1211 285054 SGTC_2988 9073640 71.4286 µM 0.705250482771622 0.263512070167823 no 914 0.240327184978579 1195 9102229 SGTC_359 0081-0058 15.9 µM 0.704575051679165 0.263719176707785 no 915 0.240537364408699 1226 3494159 SGTC_2956 9076196 2.52 µM 0.70449695455647 0.263743128878531 no 916 0.240561672984257 1202 16423868 SGTC_694 1315-0438 43.2 µM 0.703795987573328 0.263958163165109 no 917 0.240779916419759 1110 6793154 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.703563030513301 0.264029646730059 no 918 0.240852470570134 1216 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2365 9042475 200 µM 0.702819140401181 0.264257977643146 no 919 0.241084233716415 1207 6464479 SGTC_2483 5729050 27.16 µM 0.702132370052176 0.264468865347036 no 920 0.241298308480504 1207 2865180 SGTC_2007 4011539 71.82 µM 0.701782390596262 0.264576367049851 no 921 0.241407441100262 1197 45595301 SGTC_3155 9099265 49.47 µM 0.701716334635527 0.264596659672313 no 922 0.241428042059825 1128 25236499 SGTC_2904 7225135 42.03 µM 0.701026658768788 0.264808577791099 no 923 0.24164318920655 1263 4446116 SGTC_3093 9117344 49.47 µM 0.700939822256762 0.264835266339117 no 924 0.241670285579883 1146 24824913 SGTC_291 SEC14.278 35.5 µM 0.700355498606746 0.26501488936184 no 925 0.24185266019785 1201 1068044 SGTC_2727 riluzole 51.77 µM 0.70020197951913 0.265062091902419 no 926 0.241900587782503 1182 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_939 1165-0479 45.3 µM 0.698580730162969 0.265560838295033 no 927 0.242407044879744 1152 1377347 SGTC_1859 st055998 20 µM 0.698151349992205 0.265693008586333 no 928 0.24254127378696 1211 676301 SGTC_131 0141-0277 33.849 µM 0.696171152168175 0.266302977386399 no 929 0.243160825707307 1143 1547771 SGTC_2987 9018338 71.43 µM 0.695760799545601 0.266429468650694 no 930 0.243289321220704 1234 5055682 SGTC_3060 1327-0027 12.5 µM 0.694640972803735 0.266774810014804 no 931 0.243640164126445 1137 16000455 YPR107C YTH1 SGTC_2269 7935389 174.42 µM 0.694352474695181 0.266863816063257 no 932 0.243730595127907 1138 97605 SGTC_528 3492-0019 172 µM 0.693576738860961 0.267103216736236 no 933 0.243973842777493 1235 2869262 SGTC_1768 st044301 37.178 µM 0.690475848290381 0.268061267651765 no 934 0.244947496473884 1226 3931349 SGTC_452 diindolylmethane 8 µM 0.690461622561365 0.268065666814855 no 935 0.244951968046476 1156 3071 Inhibits expression of several cancer promoting factors. SGTC_801 0866-0028 10.1 µM 0.687431377151012 0.269003567199292 no 936 0.245905465271473 1240 6849771 SGTC_1826 st055655 41.6 µM 0.68667614240473 0.269237578337304 no 937 0.246143417193027 1218 676168 SGTC_3094 9117742 49.47 µM 0.684824172794862 0.269811847028138 no 938 0.246727439837862 1190 17149698 SGTC_48 0382-0018 55 µM 0.684290727329876 0.269977374362933 no 939 0.246895800563442 1318 762596 SGTC_1313 1220-0047 237 µM 0.682901014809242 0.270408838607377 no 940 0.247334696330188 1233 3528706 SGTC_2567 aureobasidin a 60 nM 0.681947705786303 0.270705011748633 no 941 0.247636009169178 1277 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2489 cantharidin 73.42 µM 0.681887317858951 0.270723778466329 no 942 0.247655102611209 1209 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2051 5263410 176 µM 0.680807799620483 0.271059369220609 no 943 0.247996557078284 1280 227584 SGTC_1018 4259-0013 28.1 µM 0.679783137582496 0.271378098608659 no 944 0.248320892618921 1212 6801262 SGTC_19 0279-0214 38.434 µM 0.67964677174465 0.271420530378015 no 945 0.24836407344323 1277 3566274 YBR002C RER2 SGTC_1764 st044502 93.5 µM 0.677664716042441 0.272037642300664 no 946 0.248992151458991 1228 8407 SGTC_71 0417-1750 47.813 µM 0.677509131073858 0.272086113109721 no 947 0.249041489304844 1204 6811472 SGTC_832 4083-0019 164 µM 0.677371348614651 0.27212904132483 no 948 0.249085186105413 1312 1990758 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.676379394990409 0.272438198865245 no 949 0.249399898020958 1186 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_3195 9113082 49.47 µM 0.675817418024466 0.272613424964949 no 950 0.249578287241473 1194 17018038 SGTC_1957 st077035 62.4 µM 0.675123328522678 0.272829921333948 no 951 0.249798706677934 1289 705593 SGTC_1986 st071812 45 µM 0.675014814284589 0.272863776172546 no 952 0.249833176483227 1198 11838594 SGTC_2004 4023728 41.89 µM 0.674972121380681 0.272877096298735 no 953 0.249846738677617 1209 360084 YDR527W RBA50 SGTC_3144 9087057 49.47 µM 0.67350553388556 0.273334865263071 no 954 0.250312864670583 1173 17249618 SGTC_2054 5233173 129 µM 0.671431030280124 0.273983033110125 no 955 0.250972991347361 1238 6889 SGTC_429 1112-0049 25.5 µM 0.670450098463133 0.274289784453338 no 956 0.251285453633602 1204 2836170 SGTC_844 0330-0132 15.3 µM 0.669384070802834 0.274623338644095 no 957 0.251625255106112 1234 2828079 SGTC_1500 4488-1866 171 µM 0.668939987690127 0.274762348815081 no 958 0.251766880328168 1295 2900003 SGTC_1709 st033179 39.1045 µM 0.668285031499527 0.274967431323854 no 959 0.251975833143337 1220 573381 SGTC_1136 pergolide 1.05886 µM 0.666583452161821 0.275500588909759 no 960 0.252519120991865 1226 47811 A dopamine receptor agonist. SGTC_1326 1431-2094 10.8 µM 0.662490924018208 0.276784983390897 no 961 0.253828324766826 1223 616278 SGTC_1515 3460-0031 42.1 µM 0.661654769004107 0.277047761766477 no 962 0.254096249271769 1213 2876596 SGTC_1898 st060199 18.6 µM 0.659954405044983 0.277582511363913 no 963 0.254641544662157 1268 688866 SGTC_1084 voriconazole 435 nM 0.658262672095627 0.278115046580118 no 964 0.255184679746389 1259 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_872 0588-0139 234 µM 0.658233932816163 0.278124097629226 no 965 0.255193911793959 1263 2047100 SGTC_1520 flindersine 88 µM 0.657383534207062 0.278391984225509 no 966 0.255467168174188 1342 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1444 4112-3581 28 µM 0.656251076296962 0.278748918268629 no 967 0.255831295149966 1268 2877249 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.653110712864388 0.279739878333869 no 968 0.256842453172699 1286 165521 SGTC_996 3970-0799 1.8 µM 0.653035549316981 0.279763617561658 no 969 0.256866680363297 1366 6615648 YGL040C HEM2 SGTC_2595 hexamethylquercetagetin 100 µM 0.652460127763861 0.279945387812159 no 970 0.25705219327724 1210 386331 SGTC_1284 0929-0043 16 µM 0.65122080311177 0.280337073178348 no 971 0.257451981637854 1249 1239883 SGTC_2442 5158906 48.48 µM 0.651111823493944 0.28037152859666 no 972 0.257487152345078 1286 1893835 SGTC_1678 st019265 80.2 µM 0.650463841746702 0.280576439349941 no 973 0.257696325328872 1298 5367020 SGTC_2363 9053361 176 µM 0.646279753308269 0.281901312155779 no 974 0.259049098807916 1325 6469797 YMR079W SEC14 SGTC_125 0133-0007 11.75 µM 0.643618797325735 0.282745456928044 no 975 0.259911328965999 1345 26541 SGTC_2262 9014885 67.46 µM 0.641703722927499 0.283353733550455 no 976 0.260532785754373 1228 6457424 SGTC_1596 piperlongumine 63 µM 0.64095578708226 0.283591467371705 no 977 0.260775704433042 1303 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1190 1486-1332 13 µM 0.640529432752061 0.283727028220874 no 978 0.260914230245226 1259 4150046 SGTC_3022 9087993 49.47 µM 0.64039045139152 0.283771224535794 no 979 0.260959394539499 1292 17173644 SGTC_2224 6650123 117.647 µM 0.639413551086187 0.284081973518184 no 980 0.261276967872876 1244 2908370 SGTC_1060 3448-7350 82 µM 0.638617187993048 0.284335414536409 no 981 0.261535998513665 1265 570178 SGTC_1402 3909-7673 35.9 µM 0.637000035591983 0.284850402431306 no 982 0.262062410207197 1271 5328014 SGTC_1272 0839-0021 27 µM 0.632960036812388 0.286138895271206 no 983 0.263379870190328 1308 5027250 SGTC_1048 3161-0300 24.5 µM 0.632666826293658 0.286232517726201 no 984 0.263475618779174 1296 2165101 SGTC_2733 amorolfine 100 µM 0.631368884147837 0.286647126770569 no 985 0.263899678147245 1318 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_289 k017-0060 526 µM 0.630937666988371 0.286784935922023 no 986 0.264040640950234 1275 5512909 SGTC_369 0957-0393 4.5 µM 0.630731394999681 0.286850867795476 no 987 0.264108083828678 1268 6997992 SGTC_1042 0350-0096 82 µM 0.629012262907777 0.287400642849135 no 988 0.264670513994532 1294 3122515 SGTC_3125 9127534 49.47 µM 0.624254181530567 0.288924860978819 no 989 0.266230334589271 1215 1639235 SGTC_336 4111-0029 111 µM 0.623500266403546 0.289166721096989 no 990 0.266477913621972 1261 3131175 SGTC_3216 9129716 49.47 µM 0.623314297924143 0.289226395441065 no 991 0.266539001920841 1262 8056934 SGTC_390 dec-rvkr-cmk 16.7 µM 0.621682101678225 0.289750389603549 no 992 0.267075461475296 1358 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_740 k014-0057 261 µM 0.621480520581278 0.289815135335243 no 993 0.267141753630617 1352 4012779 SGTC_1725 st036284 20.55 µM 0.621351021275711 0.289856732732725 no 994 0.267184345279775 1334 707914 SGTC_741 4582-0002 126 µM 0.621316810446719 0.289867722305236 no 995 0.267195597616099 1287 2912688 SGTC_256 clotrimazole 625 nM 0.620118461376306 0.290252792213304 no 996 0.267589899316024 1309 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1662 st014054 52 µM 0.619345868914508 0.290501179158443 no 997 0.267844266585756 1309 2838777 SGTC_1421 4029-0249 71.4 µM 0.616533916911199 0.291406055046464 no 998 0.268771096984567 1406 2894095 SGTC_2947 9072639 7.68 µM 0.615278992928227 0.291810308948042 no 999 0.269185244125622 1299 16488146 SGTC_665 3914-0008 307 µM 0.614076839554303 0.292197808482725 no 1000 0.269582276039424 1275 1069549 SGTC_3140 9094243 49.47 µM 0.613897048209957 0.2922557826124 no 1001 0.269641680449229 1327 19291112 SGTC_3041 9091929 49.47 µM 0.613597015482763 0.292352540763631 no 1002 0.269740828115195 1360 25236887 SGTC_1891 st059073 26.2 µM 0.613407575017891 0.292413641467176 no 1003 0.269803439287803 1358 688754 SGTC_1954 st077032 68.9 µM 0.613261581335487 0.292460733222358 no 1004 0.269851696011215 1239 698907 SGTC_2134 5324836 1.464 µM 0.612557855387916 0.292687776658696 no 1005 0.270084366046859 1325 699272 SGTC_1297 1068-0111 14.1 µM 0.611922026506473 0.292892984804789 no 1006 0.270294673822574 1270 767057 SGTC_722 3534-0461 190 µM 0.611779557358357 0.29293897461794 no 1007 0.270341808370903 1286 658262 SGTC_3019 9081971 49.47 µM 0.611711117585247 0.292961068539131 no 1008 0.270364452472923 1381 16451803 SGTC_1613 st002381 52.1 µM 0.611708858696261 0.292961797773246 no 1009 0.270365199869012 1316 551167 SGTC_1926 methyl fluorone black 53.6 µM 0.609817861852723 0.29357256102413 no 1010 0.270991233962281 1190 72721 Reacts with homocysteine. SGTC_622 1348-1566 26.3 µM 0.608830719398433 0.293891627082802 no 1011 0.271318324744981 1372 7340407 SGTC_525 k781-2675 26.7 µM 0.607498713928015 0.29432241445652 no 1012 0.271759997933864 1364 3651118 YDL195W SEC31 SGTC_1913 st060213 96.1 µM 0.607104891670824 0.294449837374233 no 1013 0.271890652038238 1349 688959 SGTC_994 3910-0338 138 µM 0.604641414791131 0.295247483333635 no 1014 0.272708641263648 1416 3479481 SGTC_1385 3091-4834 14.1 µM 0.604212140456288 0.295386579202895 no 1015 0.272851305202549 1351 4072814 SGTC_1641 st009299 47.1 µM 0.603861114918823 0.295500342860385 no 1016 0.27296799164018 1281 4046054 SGTC_160 3453-0671 289.699 µM 0.601961607798584 0.296116302220553 no 1017 0.273599846703324 1278 5322268 SGTC_837 0091-0265 12.5 µM 0.60032062534121 0.296648902803883 no 1018 0.274146287775951 1314 759367 SGTC_1848 st056003 16.4 µM 0.596357940073353 0.297936845369761 no 1019 0.275468066029197 1379 146492 SGTC_2591 skatole 100 µM 0.594035811300715 0.298692760775081 no 1020 0.276244080586685 1364 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1400 3771-8998 51.5 µM 0.593535257966348 0.298855818519191 no 1021 0.276411497131085 1327 670767 SGTC_1211 1056-0033 32.3 µM 0.59243296346339 0.29921503896931 no 1022 0.276780349158635 1353 6741922 SGTC_1843 st055809 45.5 µM 0.592379192242076 0.299232567175887 no 1023 0.276798348360037 1344 16413835 SGTC_2856 9022925 19.48 µM 0.592159045084747 0.29930433504682 no 1024 0.276872045672359 1369 4944862 SGTC_732 3970-1727 52.7 µM 0.592082812895585 0.299329188524926 no 1025 0.276897567693989 1395 1275699 SGTC_2814 7977482 42.97 µM 0.591691395292321 0.299456814565618 no 1026 0.277028629802253 1420 6456762 SGTC_37 0566-0070 1.56 µM 0.591474133762429 0.29952766573715 no 1027 0.277101390665407 1375 1626686 SGTC_2742 clothiapine 36.27 µM 0.591445932774279 0.299536862920312 no 1028 0.277110835859016 1349 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_254 nsc-64875 3.808 µM 0.590922623135265 0.299707553017586 no 1029 0.277286133505643 1465 56993 SGTC_226 1,3-diallylurea 8.28947 mM 0.590720431980726 0.299773514351197 no 1030 0.277353877782822 1316 74537 YKL182W FAS1 SGTC_1161 k007-0610 110 µM 0.58755875334141 0.300805810733369 no 1031 0.278414251666684 1413 5843850 SGTC_1057 3448-5381 134 µM 0.586135233909706 0.30127111654895 no 1032 0.278892320283376 1400 5497911 SGTC_738 1315-0003 72.4 µM 0.584515208116272 0.301801048396015 no 1033 0.279436868198941 1395 6251474 SGTC_2883 9059145 45.46 µM 0.58431024283211 0.301868125096936 no 1034 0.279505801057606 1341 16476510 SGTC_1643 st009866 20.2 µM 0.584162186321378 0.30191658206572 no 1035 0.279555599789471 1359 3156273 YOR207C RET1 SGTC_23 0213-0011 39.996 µM 0.583573111641566 0.302109413144823 no 1036 0.279753777411194 1407 627608 SGTC_919 tnp00227 403.569 nM 0.579921971662924 0.303305829577323 no 1037 0.280983619084198 1397 1269246 A methoxyflavone. YNL221C POP1 SGTC_2588 indole-3-carbinol 100 µM 0.578143926600338 0.303889230431928 no 1038 0.281583476244933 1419 3712 Induces cell cycle arrest. SGTC_1559 coumarin 343 70.1 µM 0.577892015273957 0.30397192643797 no 1039 0.281668513225198 1427 108770 A hepatotoxic, DNA x-linker. SGTC_2127 5253358 187.912 µM 0.577175725444468 0.304207120762415 no 1040 0.28191037675525 1325 20612 SGTC_2476 5806916 10.51 µM 0.575638678522168 0.304712084715992 no 1041 0.282429715855096 1336 2870194 SGTC_2830 7992007 71.43 µM 0.575609993144874 0.304721512226029 no 1042 0.282439412474112 1384 1952075 SGTC_123 0083-0120 66.675 µM 0.575161188079754 0.304869029845197 no 1043 0.282591144474953 1313 16001701 SGTC_1291 0993-0025 5.79 µM 0.57412428264997 0.305209971305737 no 1044 0.282941851191307 1431 4353356 SGTC_1965 Pectolinarigenin 58.4 µM 0.574072514543745 0.305226997440319 no 1045 0.28295936590361 1357 5320438 An anti-inflammatory. SGTC_1246 0422-0085 105 µM 0.573552227507411 0.305398139270253 no 1046 0.283135423605489 1377 264295 SGTC_807 1315-0151 48 µM 0.573288857746508 0.305484787636714 no 1047 0.283224564204311 1407 4011080 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.573140985911342 0.305533442087504 no 1048 0.283274619069763 1380 6708784 An antioxidant flavonoid SGTC_3190 9110366 49.47 µM 0.571988645903499 0.305912715542544 no 1049 0.283664833394508 1344 17123768 SGTC_345 1362-0200 395 µM 0.569340745482391 0.306785016187704 no 1050 0.284562460276771 1363 1419823 SGTC_1996 st072960 66.8 µM 0.568055202044232 0.307208909419728 no 1051 0.284998742591446 1364 1719405 SGTC_937 3122-0005 46.7 µM 0.567827550132156 0.307284001909272 no 1052 0.285076035369439 1389 759535 SGTC_3275 9138069 49.47 µM 0.566028476749667 0.307877722223318 no 1053 0.285687211212264 1409 17617007 SGTC_3308 9128332 17.569 µM 0.565253811869646 0.308133527992086 no 1054 0.285950569922644 1475 17332805 YDL196W YDL196W SGTC_2839 9003951 25.97 µM 0.564822154192236 0.308276108179886 no 1055 0.286097368343806 1399 2990634 SGTC_2508 celastrol 40.54 µM 0.564032018611676 0.308537171589702 no 1056 0.286366170877039 1338 122724 Celastrol is a natural product and antioxidant. SGTC_3231 9132313 49.47 µM 0.563107304603813 0.308842823119928 no 1057 0.286680908884296 1415 4905967 SGTC_2470 5664817 21.68 µM 0.562330111895068 0.309099815954659 no 1058 0.286945562963908 1419 2859561 SGTC_2730 imipramine 71.33 µM 0.562278725443047 0.30911681111001 no 1059 0.286963065449339 1414 3696 A tricyclic antidepressant. SGTC_179 1273-0063 6.77 µM 0.560689803361567 0.309642520305021 no 1060 0.287504509768605 1363 3108139 SGTC_2990 9074105 71.4286 µM 0.560468622482504 0.309715730913276 no 1061 0.287579918099821 1399 6502001 SGTC_1321 1326-2144 215 µM 0.5581834043654 0.310472576893454 no 1062 0.288359576033918 1429 3513030 SGTC_228 caffeine 993.056 µM 0.557746631068362 0.310617324232743 no 1063 0.288508705267609 1421 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1895 st058434 18.3 µM 0.554345524992692 0.311745457791433 no 1064 0.289671199862 1429 5393175 SGTC_2136 5328288 199.296 µM 0.549288617745318 0.31342608268031 no 1065 0.291403698673542 1378 262395 SGTC_1656 st012921 11 µM 0.548750289805522 0.31360522107634 no 1066 0.291588414432601 1426 6732821 SGTC_1020 4335-0961 93.3 µM 0.547868071556834 0.313898890266936 no 1067 0.291891246808688 1346 669075 SGTC_2707 st078556 66.6 µM 0.546027579314732 0.314511925226812 no 1068 0.292523489764298 1439 17250899 SGTC_2033 5192550 145 µM 0.545862724183223 0.314566860512184 no 1069 0.292580151578276 1387 182073 SGTC_2072 5231554 129 µM 0.545221478467663 0.314780584228706 no 1070 0.292800600512595 1481 789545 SGTC_2095 5432005 200 µM 0.544311327495624 0.315084039144263 no 1071 0.29311362665675 1406 783734 SGTC_146 3448-8650 53.125 µM 0.544209879466451 0.31511787083335 no 1072 0.293148527057213 1468 2891488 YIL048W NEO1 SGTC_824 1304-0008 100 µM 0.543587504953199 0.315325459129863 no 1073 0.293362680029755 1426 768245 SGTC_1264 0783-0040 158 µM 0.543272803158002 0.31543044772816 no 1074 0.293470993422121 1369 2855798 SGTC_1529 apigenin 74 µM 0.543261140779216 0.315434338735324 no 1075 0.293475007710688 1507 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1021 4476-0760 85.3 µM 0.541813394179214 0.315917520179579 no 1076 0.293973531654267 1387 746768 SGTC_821 1114-0266 29.2 µM 0.538968365109218 0.316867957061224 no 1077 0.294954341536734 1407 3123235 SGTC_2576 guaiol 23.12 µM 0.538631107620158 0.316980704765993 no 1078 0.295070709304366 1464 227829 SGTC_2417 cerulenin 830 nM 0.534300687682039 0.318429903713859 no 1079 0.296566758256977 1477 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1320 1313-0481 95.3 µM 0.534059875033116 0.318510574869797 no 1080 0.296650054747639 1451 6813365 YLR208W SEC13 SGTC_2658 polymyxin b sulfate 77.05 µM 0.533994245940622 0.31853256181329 no 1081 0.296672757543822 1411 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2962 9082311 13.18 µM 0.531096113097685 0.319504125459592 no 1082 0.297676088794484 1384 16459453 SGTC_2439 5492030 7.2 µM 0.530783443689993 0.319609018300309 no 1083 0.297784427162506 1437 5722370 SGTC_2139 5578692 56.4705 µM 0.52857716178787 0.320349581045147 no 1084 0.298549403337687 1449 650991 YMR113W FOL3 SGTC_1870 st057514 26.5 µM 0.526087378923128 0.321186163946961 no 1085 0.299413748689244 1439 5393161 SGTC_2043 5101342 149 µM 0.526047513803786 0.321199566279558 no 1086 0.299427597366558 1410 678451 SGTC_3341 9147222 25.867 µM 0.52575466433083 0.321298027055576 no 1087 0.299529338758361 1432 1939759 SGTC_302 1094-0063 18.9 µM 0.523951361673516 0.321904603460229 no 1088 0.300156184884897 1396 5440289 SGTC_1118 chelidonine 707.474 nM 0.522384938273753 0.322431886348374 no 1089 0.300701170361675 1536 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_3217 9129673 49.47 µM 0.522103177766579 0.32252676934796 no 1090 0.300799247027885 1441 17248312 SGTC_103 0844-0104 51.839 µM 0.521824201958646 0.322620725987947 no 1091 0.300896368597211 1484 5375804 SGTC_3013 9080133 71.4286 µM 0.521422105659419 0.32275616847327 no 1092 0.301036377738423 1519 17050193 SGTC_2310 7668677 200 µM 0.521011727180502 0.322894424984359 no 1093 0.301179300989138 1503 2197143 SGTC_2152 5568786 200 µM 0.519639614714217 0.323356867344907 no 1094 0.301657390886739 1435 5399883 SGTC_8 0354-0001 70 µM 0.51855176956435 0.323723697330569 no 1095 0.30203667492047 1491 4993152 SGTC_2792 7535235 81.82 µM 0.518158944888794 0.323856203038499 no 1096 0.302173688318661 1415 1281891 SGTC_849 0386-0493 241 µM 0.517878526807932 0.323950805959638 no 1097 0.30227151246039 1415 726119 SGTC_2408 sulbentine 18.36 µM 0.517852522243471 0.323959579535701 no 1098 0.30228058489992 1540 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2776 terbinafine 19.92 µM 0.517682600371449 0.324016911204048 no 1099 0.302339870034752 1436 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2932 9016711 44.54 µM 0.516563139956499 0.32439472162568 no 1100 0.302730576079276 1549 7117328 SGTC_2329 6138490 200 µM 0.515285269233239 0.324826215500949 no 1101 0.303176845565494 1485 720019 SGTC_2287 7945887 168.79 µM 0.515143117503171 0.324874229893306 no 1102 0.303226507247125 1488 1245853 SGTC_3254 9136651 49.47 µM 0.514316765169954 0.325153403365933 no 1103 0.303515271097032 1422 16454030 SGTC_2972 9093619 59.92 µM 0.513787478933764 0.325332268123527 no 1104 0.303700291488072 1405 25236256 SGTC_746 1095-0025 46.6 µM 0.512483088432082 0.325773240075705 no 1105 0.304156476596659 1542 6749286 SGTC_2691 st077356 60.2 µM 0.512017942012178 0.325930549955134 no 1106 0.30431922629092 1555 2839272 SGTC_2686 alizarin 95.37 µM 0.510686207816033 0.326381106202671 no 1107 0.304785399947683 1432 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_546 peri-Naphthalide 147 µM 0.510375841137699 0.326486146815132 no 1108 0.304894089419298 1524 223824 A penicillin ester. SGTC_905 2-aminofluorene 215 µM 0.509251281607917 0.326866858356891 no 1109 0.3052880509249 1475 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.508653529872947 0.327069296323937 no 1110 0.305497550285838 1455 16486 A toxic proline analog. SGTC_2630 antimycin a 100 µM 0.507858502643477 0.327338623572126 no 1111 0.305776289247677 1407 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2958 9077254 16.72 µM 0.506677499936721 0.327738871675505 no 1112 0.30619056015245 1469 16457351 SGTC_2097 5376186 200 µM 0.504727877953229 0.328400042002146 no 1113 0.306874988884334 1534 742755 SGTC_401 neomycin 50 µM 0.50255151266763 0.3291387424291 no 1114 0.307639813320484 1461 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_3092 9117248 49.47 µM 0.500773252194169 0.329742814199004 no 1115 0.308265356086548 1563 17141857 SGTC_2703 st077852 53.4 µM 0.49944013116007 0.33019596448923 no 1116 0.308734676713331 1508 6281836 SGTC_697 0508-1955 564 µM 0.499095359997842 0.3303131985959 no 1117 0.308856103101593 1559 6243113 SGTC_3167 9103034 49.47 µM 0.498652798336209 0.330463709265333 no 1118 0.309012001357742 1499 5127859 SGTC_2889 9059656 51.95 µM 0.498484323710433 0.330521012961843 no 1119 0.309071357838487 1544 3949838 SGTC_2487 5918373 44.05 µM 0.498445000355429 0.3305343886851 no 1120 0.309085212843975 1529 2876279 SGTC_3158 9100007 49.47 µM 0.498329103283221 0.330573811991559 no 1121 0.309126049051545 1459 19297233 SGTC_396 dithiazanine 1.25 µM 0.496019672543831 0.33135977459819 no 1122 0.309940265675572 1438 10578 An antihelmenthic. SGTC_1088 bifonazole 369 nM 0.495821643521093 0.331427203955768 no 1123 0.31001012659606 1451 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_3284 9108171 64.8615 µM 0.494555502017545 0.331858457261948 no 1124 0.310456959596361 1503 8687505 SGTC_339 3091-4833 71.4 µM 0.494534163439237 0.331865727185898 no 1125 0.310464492576962 1523 3240077 SGTC_2743 auranofin 4.32 µM 0.493438757669674 0.332239010261298 no 1126 0.310851301277443 1515 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2383 9036125 200 µM 0.492691658038765 0.332493696058003 no 1127 0.311115236406727 1519 79580 SGTC_3082 9117008 49.47 µM 0.490942986616715 0.333090119288256 no 1128 0.311733386206242 1489 41448529 SGTC_1948 st076329 66.6 µM 0.490200543177272 0.333343473953567 no 1129 0.311995998247035 1419 24208413 SGTC_2077 5212015 200 µM 0.488444895068282 0.333942881423742 no 1130 0.312617374243458 1399 780900 SGTC_2634 4'-methoxyflavone 100 µM 0.487690978621249 0.33420041123707 no 1131 0.312884371355543 1503 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2606 farnesol 9.78 µM 0.487452399225771 0.334281923680535 no 1132 0.31296888394738 1578 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1393 3470-5649 58.2 µM 0.486410186165794 0.33463809520092 no 1133 0.313338184960026 1466 4108395 SGTC_3123 9126162 49.47 µM 0.484576167525481 0.335265223929363 no 1134 0.313988511342539 1528 25239884 SGTC_1602 st001878 87.6 µM 0.479100763985704 0.337140223915112 no 1135 0.315933473135169 1544 595405 YLR310C CDC25 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.477462133085991 0.337702147618377 no 1136 0.316516539587586 1498 75037 A free radical scavenger. SGTC_2388 9080168 200 µM 0.47710505309018 0.337824646527919 no 1137 0.316643658311426 1455 15943073 SGTC_2665 lovastatin 100 µM 0.476465107208481 0.338044227630302 no 1138 0.316871530081826 1498 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1881 5652484 16 µM 0.475494044816234 0.338377528162458 no 1139 0.317217438440241 1595 2255129 SGTC_3057 9095946 49.47 µM 0.473763979399337 0.338971657223805 no 1140 0.317834111823195 1541 24540043 SGTC_687 k029-0044 34.9 µM 0.473273961111308 0.33914000936374 no 1141 0.318008868408465 1634 5829338 SGTC_2341 7987486 176.74 µM 0.473065162070067 0.33921175474514 no 1142 0.318083345308646 1648 1258686 SGTC_2334 9017922 200 µM 0.47298310111446 0.339239953283713 no 1143 0.318112617790365 1661 3163164 SGTC_2506 ethyl hematommate 54.16 µM 0.471339794025367 0.339804830914378 no 1144 0.318699051228208 1453 3940691 An allergen. SGTC_1163 k060-0048 49.9 µM 0.471078142826785 0.339894805300886 no 1145 0.318792466499147 1516 6809982 SGTC_338 4055-0136 114 µM 0.470633415483968 0.340047755277866 no 1146 0.31895127042327 1474 2900563 SGTC_791 1348-1292 225 µM 0.470365937934743 0.340139758446202 no 1147 0.319046797728596 1579 5437054 SGTC_1139 k015-0024 46.9 µM 0.470156802818881 0.340211700435582 no 1148 0.319121496908802 1551 2766652 SGTC_1065 prochlorperazine maleate 2.48 µM 0.469898402014384 0.340300597740032 no 1149 0.319213803022484 1540 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_361 000s-0510 1.45 µM 0.469265864974006 0.340518246113088 no 1150 0.319439805631721 1532 660 SGTC_867 0518-0118 155 µM 0.469029816501572 0.34059948116268 no 1151 0.319524161872449 1542 6848158 SGTC_2983 9022671 12.99 µM 0.468918407065161 0.340637824801977 no 1152 0.319563979317694 1657 6405161 SGTC_1346 1488-2224 62.4 µM 0.468090282131828 0.340922891067455 no 1153 0.319860014205832 1572 3722427 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.467974374475572 0.340962797325943 no 1154 0.319901457585218 1667 5024745 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.467741700953697 0.341042910689683 no 1155 0.319984657986475 1677 1273210 SGTC_3116 9124943 49.47 µM 0.467531438431728 0.341115313738454 no 1156 0.320059852354833 1436 41905195 YPL160W CDC60 SGTC_506 n9-isopropylolomoucine 153 µM 0.466040149835569 0.341629000700422 no 1157 0.320593380999006 1672 6610355 SGTC_1371 2421-0008 32.7 µM 0.45754934086204 0.344559298780476 no 1158 0.323638123068429 1551 2827552 SGTC_3160 9100216 49.47 µM 0.456643356819621 0.344872521932291 no 1159 0.32396370514862 1554 17191039 SGTC_185 k048-0037 25.491 µM 0.455442500628738 0.345287854223121 no 1160 0.324395462574577 1615 6827589 SGTC_1931 st074438 57.1 µM 0.45457093941891 0.345589412172284 no 1161 0.324708972801589 1498 2787313 SGTC_3053 9095903 49.47 µM 0.45417577764586 0.345726169440664 no 1162 0.324851157814907 1598 17174018 SGTC_2092 5303694 80.6725 µM 0.454092827414951 0.345754879347113 no 1163 0.324881007768482 1523 1963699 SGTC_610 4215-0184 155 µM 0.452018580215412 0.346473085132453 no 1164 0.325627798619275 1578 5605015 SGTC_2882 9058044 58.44 µM 0.451980277273468 0.346486352684654 no 1165 0.325641595415827 1467 18076804 SGTC_464 bw-b 70c 158 µM 0.450372358426415 0.347043480856423 no 1166 0.326220986285125 1620 5353454 SGTC_1609 st001574 46.4 µM 0.450228615047411 0.347093302657856 no 1167 0.326272802639525 1530 3960012 SGTC_920 mycophenolic acid 780.421 nM 0.44980261952833 0.347240969251437 no 1168 0.326426384429754 1544 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3023 9089636 49.47 µM 0.449412398316541 0.347376255435008 no 1169 0.326567094536543 1623 17249241 SGTC_2387 9077560 195.08 µM 0.448702919849337 0.347622275046106 no 1170 0.326822989025331 1506 5303272 SGTC_18 0111-0177 500 nM 0.448102612259361 0.347830488570388 no 1171 0.327039571432438 1588 721752 SGTC_141 0443-0274 32.331 µM 0.447894898994668 0.347902543513209 no 1172 0.327114524984538 1611 1627241 SGTC_208 k072-0098 12.366 µM 0.447189146547517 0.348147407382558 no 1173 0.327369248589118 1561 5948901 SGTC_547 1120-0019 610 nM 0.446961198291885 0.348226508551096 no 1174 0.327451537965425 1575 3676939 SGTC_2190 6049624 200 µM 0.442855183404006 0.34965247966326 no 1175 0.328935242758866 1591 2265554 SGTC_1726 st035556 14.5795 µM 0.442639974759594 0.349727277865032 no 1176 0.329013082861199 1655 5919439 SGTC_1802 st050112 57.9 µM 0.442246014965133 0.349864218164991 no 1177 0.329155595746576 1560 4662563 SGTC_2206 7254556 146.969 µM 0.441902771316696 0.349983545471541 no 1178 0.329279782575753 1623 4398905 SGTC_2445 5742597 35.57 µM 0.440603779057913 0.350435269078414 no 1179 0.329749933256675 1531 1774255 SGTC_505 gw-5074 63.9 µM 0.439435143008223 0.350841842265474 no 1180 0.330173133491796 1641 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2925 9010536 32.5 µM 0.437686861599311 0.351450395293595 no 1181 0.33080664744171 1656 2994177 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.437464589094298 0.351527792664502 no 1182 0.330887225738012 1526 2333 A French combination drug. SGTC_978 1416-0512 87.4 µM 0.436751899981435 0.351775999195685 no 1183 0.331145642836267 1607 6814003 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.436505425121212 0.351861853116029 no 1184 0.331235031973884 1512 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_631 k072-0230 41.5 µM 0.436268239191498 0.351944478580778 no 1185 0.331321061372171 1613 5773147 SGTC_2325 6158266 200 µM 0.4347035236479 0.352489733803059 no 1186 0.331888820201807 1560 3623240 SGTC_2809 7964133 12.99 µM 0.434312609105836 0.352626002881701 no 1187 0.332030724348355 1595 1253665 SGTC_52 0329-0193 875 nM 0.433390614862251 0.352947476159144 no 1188 0.332365508770123 1656 3739292 SGTC_3076 9116187 49.47 µM 0.429690489122423 0.354238659417834 no 1189 0.333710401400804 1705 27241210 SGTC_2870 9038528 12.99 µM 0.428875880938053 0.35452314813284 no 1190 0.334006776731454 1556 6463316 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.428135471664097 0.354781794508718 no 1191 0.334276246443165 1553 4330530 SGTC_387 norethindrone acetate 66.7 µM 0.427755401457587 0.354914590039186 no 1192 0.334414605034543 1578 541197 SGTC_1382 3002-2117 298 µM 0.426152621791978 0.355474790788625 no 1193 0.334998319075573 1696 1497314 SGTC_1483 3453-0561 55.9 µM 0.425839712682753 0.355584194717523 no 1194 0.335112323568438 1627 4546991 SGTC_1013 4112-3890 241 µM 0.424831605532141 0.355936744988564 no 1195 0.335479717980719 1558 705171 SGTC_779 1360-0071 233 µM 0.423078990234902 0.356549954183292 no 1196 0.336118815286759 1746 7566 SGTC_1744 st037937 38.9 µM 0.422082763067811 0.356898681993143 no 1197 0.336482304435786 1645 1016152 SGTC_2846 9008642 19.48 µM 0.421572425248537 0.357077371324249 no 1198 0.336668568449425 1577 2992898 SGTC_35 0133-0054 64.071 µM 0.419051918091201 0.357960359124949 no 1199 0.337589094684528 1512 99677 SGTC_3065 9113888 49.47 µM 0.417403811456726 0.358538137797847 no 1200 0.338191533743756 1661 16648368 SGTC_664 1222-0054 14.9 µM 0.416756930294049 0.358765004288282 no 1201 0.338428104191 1604 6813991 SGTC_1360 1598-0022 39.8 µM 0.414159757845999 0.359676354813041 no 1202 0.339378555590084 1695 761525 SGTC_1480 1070-0044 41.2 µM 0.414121461374578 0.359689799071617 no 1203 0.339392578087617 1662 3124987 SGTC_3012 9080433 71.4286 µM 0.413817959181774 0.359796351893127 no 1204 0.339503715216994 1715 17688859 SGTC_1286 0929-0070 131 µM 0.412881800085536 0.360125085000291 no 1205 0.339846607999779 1681 1420408 SGTC_3356 9151811 4.48 µM 0.411696375964023 0.360541496174083 no 1206 0.340280990798535 1582 1859254 YPR165W RHO1 SGTC_310 1273-0058 1.06 µM 0.41027380219017 0.361041430724953 no 1207 0.340802553787712 1597 2734232 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.409443224217666 0.361333430279751 no 1208 0.341107212219513 1577 115019 SGTC_2565 isoliquiritigenin 100 µM 0.409359878523694 0.361362735912279 no 1209 0.341137789387837 1522 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1608 st001473 40.5 µM 0.408649358267665 0.361612598813472 no 1210 0.341398501431433 1567 7292267 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.407875262720177 0.361884885899974 no 1211 0.341682627402878 1605 4620898 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.407351386098449 0.362069198495687 no 1212 0.34187496330776 1622 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_126 0417-1624 672.48 µM 0.407309032969851 0.362084100759365 no 1213 0.341890514616682 1710 41912 YDL195W SEC31 SGTC_3253 9135987 49.47 µM 0.405138104497674 0.362848237651373 no 1214 0.342687999381913 1643 4182430 SGTC_1034 k072-0165 12.7 µM 0.404281883804075 0.363149765965427 no 1215 0.34300272289404 1754 5835461 SGTC_2386 9075165 157.42 µM 0.402791844536372 0.363674703231488 no 1216 0.343550680620093 1637 16452277 SGTC_307 1501-1223 22.3 µM 0.399986977396652 0.364663545108373 no 1217 0.344583054238129 1630 2830329 SGTC_1503 4585-0012 61.3 µM 0.398613588576511 0.365148055521414 no 1218 0.345088973754769 1700 2922052 SGTC_1781 st038725 66.3 µM 0.398495107570541 0.365189863895868 no 1219 0.345132631964376 1621 4270275 YIL048W NEO1 SGTC_1681 tripelennamine 100 µM 0.398430651649836 0.365212609119754 no 1220 0.345156383726531 1574 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_509 pifithrin 175 µM 0.396392841769748 0.365931956138453 no 1221 0.345907622990472 1680 4817 A p53 inhibitor. SGTC_2087 5276107 200 µM 0.396013794554912 0.36606581192041 no 1222 0.34604742590841 1611 144405 SGTC_2304 7443016 91.4 µM 0.395891999035745 0.366108825945788 no 1223 0.346092351863145 1607 939854 SGTC_1904 st060225 78 µM 0.39545443967603 0.366263370873206 no 1224 0.346253769526422 1609 66595 SGTC_413 propylparaben 100 µM 0.395137195544179 0.366375434315785 no 1225 0.346370819817539 1591 7175 A pharmaceutical preservative. SGTC_1224 0823-0416 294 µM 0.394997390356226 0.366424822773619 no 1226 0.346422406952661 1709 3598164 SGTC_3196 9111891 49.47 µM 0.394186607612978 0.366711288566512 no 1227 0.346721636247414 1616 18891510 SGTC_1703 st026983 48.3 µM 0.394089948456836 0.366745445140683 no 1228 0.346757315876482 1724 1104023 SGTC_765 1319-0117 244 µM 0.39385482074879 0.366828536935408 no 1229 0.346844113839161 1566 3487746 YGL099W LSG1 SGTC_2089 5281248 129.67 µM 0.392889712765021 0.367169661837915 no 1230 0.347200469956059 1607 2737878 SGTC_3241 9133421 49.47 µM 0.392439066923008 0.367328982043029 no 1231 0.34736691256458 1656 17018221 SGTC_2019 4016004 108 µM 0.391048030677369 0.367820909493132 no 1232 0.347880866757868 1593 45595336 SGTC_1324 1418-0026 34.4 µM 0.390266936765468 0.368097231469173 no 1233 0.348169584690192 1677 1372513 SGTC_1981 st071826 47 µM 0.389752510344873 0.368279253695002 no 1234 0.348359781656274 1612 11838600 SGTC_591 4299-0174 154 µM 0.389451100619566 0.368385916836004 no 1235 0.348471238474226 1665 5509088 SGTC_892 0929-0076 29 µM 0.389082389488509 0.368516410451664 no 1236 0.348607600139207 1630 5751038 SGTC_1649 st011737 51.3 µM 0.387888360440403 0.368939103187214 no 1237 0.349049326057389 1634 1761035 SGTC_2076 5212012 200 µM 0.387617076881371 0.369035161156897 no 1238 0.349149714792002 1639 604802 SGTC_1485 3909-9022 254 µM 0.387279670452318 0.369154643785498 no 1239 0.349274587085901 1645 714516 SGTC_1988 st071872 53.4 µM 0.38659214074135 0.369398151462487 no 1240 0.349529088603006 1743 16414116 SGTC_2592 piperlongumine 83.33 µM 0.385460803261897 0.369798959969633 no 1241 0.349948020774439 1580 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1605 st000082 49.1 µM 0.383258178706364 0.370579707971523 no 1242 0.350764172351124 1708 1114022 SGTC_1429 4049-0205 9.46 µM 0.383119680493844 0.370628818260951 no 1243 0.350815513985422 1671 22774478 SGTC_2973 9094665 17.96 µM 0.380889939650983 0.3714197550757 no 1244 0.351642458909985 1768 25237061 YIL048W NEO1 SGTC_2075 5212009 200 µM 0.378538680130763 0.372254385637098 no 1245 0.352515232539762 1731 780898 SGTC_983 1491-0821 12.2 µM 0.378479185837157 0.372275512231924 no 1246 0.352537326568136 1767 46495113 SGTC_1177 0983-0204 23.6 µM 0.378233960199912 0.372362596618392 no 1247 0.352628399749262 1807 766818 SGTC_3316 9136639 10.545 µM 0.378055185491552 0.372426087103267 no 1248 0.352694799360877 1722 4903665 SGTC_543 3844-1095 191 µM 0.377936666199535 0.372468180244366 no 1249 0.352738821679884 1741 4230703 SGTC_1195 1502-0147 41.1 µM 0.376012456236297 0.373151792700811 no 1250 0.353453817844363 1623 817940 SGTC_2465 5809242 33.21 µM 0.37582408273174 0.373218737502464 no 1251 0.353523841345143 1732 2731748 SGTC_2608 thymoquinone 42.66 µM 0.374575545770255 0.373662543380202 no 1252 0.35398808135201 1635 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_598 3937-0236 20.2 µM 0.373732460158319 0.373962322047453 no 1253 0.354301686386271 1725 1379313 SGTC_2140 5586273 200 µM 0.372966831728874 0.374234625083721 no 1254 0.354586565076037 1659 854421 SGTC_3268 9137683 49.47 µM 0.372663340285832 0.374342582079221 no 1255 0.354699512149793 1670 1953228 SGTC_1561 5-methoxyflavone 52.9 µM 0.369714032020818 0.375392212428352 no 1256 0.355797787724467 1730 94525 SGTC_1422 4031-0024 15.5 µM 0.369338486444221 0.375525931893593 no 1257 0.355937721107403 1729 782427 SGTC_2753 fluvastatin 17.09 µM 0.368466638124889 0.375836426126231 no 1258 0.356262658443672 1691 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_510 ag-490 170 µM 0.368068386447815 0.375978283583615 no 1259 0.356411121350396 1776 5328779 SGTC_275 trichlorophene 5.69 µM 0.3674824042965 0.376187041204915 no 1260 0.356629607235703 1695 62616 SGTC_1751 st044839 27.194 µM 0.367046981678119 0.376342185078886 no 1261 0.356791986847799 1710 5291326 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.366681240728372 0.376472516368767 no 1262 0.356928400539464 1813 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_199 4063-0024 41.6 µM 0.366338882104627 0.376594528160994 no 1263 0.357056109693592 1760 306215 SGTC_1245 0418-0076 17.2 µM 0.365781778187007 0.376793098502 no 1264 0.357263958965373 1700 6790114 SGTC_841 0251-0215 91.2 µM 0.365224723720679 0.376991683811198 no 1265 0.357471832141308 1722 3888614 SGTC_2480 5767542 37.17 µM 0.364745853171375 0.377162423215555 no 1266 0.35765056363368 1732 2867358 SGTC_1170 0310-0127 64.8 µM 0.363435476186737 0.377629755651423 no 1267 0.358139802352553 1733 774975 SGTC_1970 st070122 35.8 µM 0.363322841210014 0.377669934127307 no 1268 0.358181866322579 1729 102928 SGTC_2624 nerol 100 µM 0.361067532296135 0.378474712506752 no 1269 0.359024481902106 1772 637566 A natural product oil. SGTC_1358 1509-0022 2.48 µM 0.36086295660328 0.378547738888282 no 1270 0.359100948311738 1709 3258434 SGTC_968 1309-0633 340 µM 0.357876272591159 0.37961437346976 no 1271 0.360217954018522 1797 3761976 SGTC_3305 9127027 53.8275 µM 0.357077349016104 0.379899848827237 no 1272 0.360516950527874 1701 41905295 SGTC_1893 st059353 36.1 µM 0.356903166765729 0.379962097194673 no 1273 0.360582149428719 1651 3112488 SGTC_460 trequinsin 123 µM 0.356193882993567 0.380215609526125 no 1274 0.360847686301742 1698 5537 A vasodilator. SGTC_1229 0139-0193 12.2 µM 0.356089809159841 0.380252811946728 no 1275 0.360886654408887 1809 3090752 SGTC_2133 5320837 200 µM 0.355859852215838 0.380335016698945 no 1276 0.360972761736723 1739 2841355 SGTC_29 0299-0004 12.984 µM 0.354279294011742 0.380900178946057 no 1277 0.361564791868767 1690 16871 A napthoquinone isolated from Swertia calycina. SGTC_1476 4112-3294 3.34 µM 0.353550905075854 0.381160715560768 no 1278 0.361837736417605 1789 704369 SGTC_3050 9093513 49.47 µM 0.350382350971123 0.382294697612916 no 1279 0.363025884916416 1682 25236664 SGTC_2989 9073649 71.4286 µM 0.350346356998148 0.382307585183655 no 1280 0.363039389584147 1835 21367202 SGTC_3120 9124077 49.47 µM 0.35022839146822 0.382349823421778 no 1281 0.363083650556636 1717 18774327 YGL155W CDC43 SGTC_2822 7994718 71.43 µM 0.347696715238525 0.383256641323472 no 1282 0.364033981897989 1725 1018011 SGTC_2122 5258151 111.688 µM 0.347534220684294 0.383314866952655 no 1283 0.364095007147066 1668 2173356 SGTC_3213 9129884 49.47 µM 0.346474288069416 0.383694730407901 no 1284 0.364493152068638 1582 17190742 SGTC_1518 st038567 90.8 µM 0.34551971574389 0.38403693006061 no 1285 0.364851845432631 1702 77966 SGTC_1201 1889-3372 45.9 µM 0.344624049496351 0.384358095017623 no 1286 0.365188511650216 1708 5392199 SGTC_1022 4477-0945 21.3 µM 0.343961145283503 0.384595848101742 no 1287 0.365437753387694 1671 4648966 SGTC_2767 sibutramine 71.45 µM 0.342727451421875 0.385038432550184 no 1288 0.365901754451418 1834 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2221 6807166 181.081 µM 0.342575543293182 0.385092939564927 no 1289 0.365958901763889 1757 674925 SGTC_136 0097-0015 404.482 µM 0.341509069158146 0.385475671047424 no 1290 0.366360189309125 1804 4861337 SGTC_416 estradiol valerate 100 µM 0.340893542963664 0.385696619139983 no 1291 0.366591862979898 1738 13791 A steroid. SGTC_1309 pyrazolanthrone 13.4 µM 0.339447853561572 0.386215706766166 no 1292 0.367136187122324 1802 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_3059 1327-0034 3 µM 0.339157693314885 0.386319915959988 no 1293 0.367245469114188 1680 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_704 1310-0270 142 µM 0.338256621718747 0.386643582294952 no 1294 0.367584904933704 1665 5718033 SGTC_2844 9010103 25.97 µM 0.337398820284979 0.386951779204139 no 1295 0.367908136923031 1718 2480525 SGTC_1563 conessine 56.1 µM 0.337147669679762 0.387042027854299 no 1296 0.368002791820906 1828 441082 An anti-amoebic, histamine inhibitor. SGTC_2959 9079155 11 µM 0.337115427806179 0.38705361411618 no 1297 0.368014943880335 1746 16189457 SGTC_409 arachidonic acid 100 µM 0.337114518921594 0.387053940729391 no 1298 0.368015286443592 1730 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2360 9040895 200 µM 0.33514620562408 0.387761453349031 no 1299 0.368757399630264 1690 4914414 SGTC_3003 9075612 71.4286 µM 0.333440809254759 0.388374761706262 no 1300 0.369400781298236 1735 6501993 SGTC_800 3448-7362 155 µM 0.333375552228799 0.388398235503227 no 1301 0.369425407590837 1770 15991913 SGTC_3285 9112818 20.8695 µM 0.333042041056668 0.388518210152454 no 1302 0.369551274336854 1736 17017947 YPR165W RHO1 SGTC_934 2950-0684 338 µM 0.332833049341843 0.388593396586738 no 1303 0.369630154704402 1849 1121253 SGTC_1098 clofazimine 15.1 µM 0.332110110082553 0.388853511919425 no 1304 0.369903058129492 1807 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_3083 9117465 49.47 µM 0.329873693301373 0.38965849525651 no 1305 0.370747700809913 1679 16420915 SGTC_581 0958-0271 211 µM 0.327631446015541 0.390466052739407 no 1306 0.371595171325221 1693 4591145 SGTC_908 3448-7491 47.7 µM 0.327411557434427 0.390545272311442 no 1307 0.371678313098841 1682 1203031 SGTC_1154 4088-0362 150 µM 0.327130239080866 0.390646629900037 no 1308 0.371784690727975 1697 6618304 SGTC_2644 guaiazulene 100 µM 0.327100749708624 0.39065725520303 no 1309 0.371795842396485 1822 3515 A coloring agent. SGTC_1952 st077036 64.1 µM 0.326966161377226 0.390705749703208 no 1310 0.371846739537235 1702 2937007 SGTC_1637 st007924 17.4 µM 0.326914340588652 0.39072442208161 no 1311 0.371866337152632 1714 683336 SGTC_2903 5923464 63.88 µM 0.324222056765763 0.391694867653104 no 1312 0.37288496218354 1839 2876576 SGTC_1572 epiandrosterone 68.9 µM 0.323560262800109 0.391933517690189 no 1313 0.373135488253331 1786 441302 A steroid. SGTC_299 1273-0059 1.44 µM 0.323464748606463 0.391967964497964 no 1314 0.373171650156166 1787 2848077 SGTC_2099 5377090 177.372 µM 0.323124807039464 0.392090569918057 no 1315 0.373300361911166 1721 2243829 SGTC_2980 9014342 25.29 µM 0.322525467443366 0.392306757520991 no 1316 0.373527323727791 1735 2996599 SGTC_3117 9124945 49.47 µM 0.322521178049914 0.392308304866679 no 1317 0.373528948221423 1658 17592065 SGTC_2158 5657123 3.6195 µM 0.320919889521726 0.392886068680653 no 1318 0.374135550428888 1801 2858827 SGTC_2750 bromebric acid 70.15 µM 0.320535472026171 0.393024806240231 no 1319 0.37428122243029 1759 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_946 3434-1334 87.4 µM 0.320516451498779 0.393031671165134 no 1320 0.374288430576509 1805 4047976 SGTC_2513 baicalein 25.65 µM 0.317884960850176 0.393981753555417 no 1321 0.375286100429945 1662 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_109 0132-0036 33.701 µM 0.314991706581566 0.395027072484386 no 1322 0.376383975389617 1835 67274 A color developer. SGTC_820 1582-0060 59.9 µM 0.314205925333042 0.395311102348652 no 1323 0.37668232132793 1725 3848840 SGTC_718 1130-0073 349 µM 0.313059897271231 0.395725447341969 no 1324 0.377117578039973 1821 6740020 SGTC_1850 st056238 17 µM 0.312438041343592 0.395950327927355 no 1325 0.377353821747609 1743 5393177 SGTC_671 0560-0003 407 µM 0.312287524112887 0.396004764398382 no 1326 0.377411010301943 1828 3238678 SGTC_2971 9092186 9.93 µM 0.311314932421979 0.396356563403481 no 1327 0.377780608248166 1628 25236400 SGTC_1096 rimcazole 32.2 µM 0.307976700790454 0.39756468536924 no 1328 0.379050030651204 1767 18528119 A dopamine reuptake inhibitor. SGTC_688 0527-0193 473 µM 0.307117685959038 0.397875726457665 no 1329 0.37937689818344 1805 4007154 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.302824564553865 0.399431194120594 no 1330 0.381011781025072 1752 279621 SGTC_1932 st074806 40.9 µM 0.301952603082723 0.399747315950368 no 1331 0.381344097332531 1831 17251235 SGTC_1359 1582-0056 520 nM 0.301945688134685 0.399749823165852 no 1332 0.38134673306277 1822 3661189 SGTC_3281 9140613 49.47 µM 0.30156931762399 0.399886293470947 no 1333 0.381490200304016 1686 16013766 SGTC_1031 k035-0009 16 µM 0.299156728097817 0.400761377666543 no 1334 0.382410232086127 1916 5180959 SGTC_2368 9071271 200 µM 0.296776032384962 0.401625381946831 no 1335 0.383318752456896 1717 27209959 SGTC_982 1491-0518 27.5 µM 0.296004860951267 0.401905359563416 no 1336 0.383613184580674 1796 3091256 SGTC_274 sirtinol 40.1 µM 0.293429191427343 0.402840833304897 no 1337 0.384597057695327 1728 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1100 amiodarone 5.07 µM 0.293185076267934 0.402929523990358 no 1338 0.384690345277739 1952 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_3337 9144342 33.5465 µM 0.29174104391059 0.403454264539981 no 1339 0.385242312571407 1868 17682949 SGTC_2694 st077685 81.9 µM 0.291379098557512 0.403585817552921 no 1340 0.385380699150459 1745 2838096 SGTC_1587 estradiol valerate 56.1 µM 0.289541959047859 0.404253713993558 no 1341 0.386083337770225 1936 13791 A steroid. SGTC_1640 st009078 66.4 µM 0.28928049163967 0.404348793830204 no 1342 0.386183369924511 1885 690618 SGTC_3010 9080089 71.4286 µM 0.289012992704415 0.40444607281407 no 1343 0.386285717449583 1894 17027233 SGTC_1504 k297-0033 30 µM 0.288674136949525 0.404569309985511 no 1344 0.386415378102451 1728 4388117 SGTC_2351 9026858 72.31 µM 0.287268155370798 0.405080747133959 no 1345 0.386953501916399 1722 1409300 SGTC_1827 berberine 7.24 µM 0.287098326591279 0.405142534716779 no 1346 0.387018516727624 1670 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2180 6301957 200 µM 0.284798309210513 0.405979565736991 no 1347 0.387899333830705 1920 845462 SGTC_534 k292-0788 63.4 µM 0.283706547636993 0.40637703446384 no 1348 0.388317638270716 1975 4146317 SGTC_3161 9100388 49.47 µM 0.282985802003221 0.406639483348219 no 1349 0.388593860355756 1850 25236368 SGTC_3096 9117468 49.47 µM 0.282708967338165 0.406740299760066 no 1350 0.388699970812179 1875 41316311 SGTC_635 k038-0028 24.7 µM 0.280510152946503 0.407541273154657 no 1351 0.389543068548805 1860 4035102 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.280318150079971 0.407611233428823 no 1352 0.389616713509554 1758 688664 SGTC_1179 1021-1431 9.29 µM 0.279379509583169 0.407953289166732 no 1353 0.38997679713507 1836 2840958 SGTC_1754 st042065 16.137 µM 0.278595852704541 0.408238920131934 no 1354 0.390277497904812 1855 1126236 YIL048W NEO1 SGTC_2722 naftopidil 47.16 µM 0.278336526507329 0.408333451316418 no 1355 0.390377019680642 1898 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_46 0329-0187a 2.197 µM 0.277528106275295 0.408628175857305 no 1356 0.390687313690805 1855 46494817 SGTC_1733 st037357 54.9 µM 0.276935692284527 0.40884418415236 no 1357 0.390914742756248 1695 1272339 YGL099W LSG1 SGTC_2502 avocadyne acetate 18.59 µM 0.276871480502436 0.408867598966748 no 1358 0.390939396046838 1781 3952079 SGTC_106 0092-0003 11.579 µM 0.275967513231174 0.409197264945264 no 1359 0.391286509167027 1925 1072148 SGTC_1238 0333-0287 48.8 µM 0.275953958456912 0.409202208697582 no 1360 0.391291714705409 1798 7226 SGTC_2791 5663188 71.43 µM 0.272375377473995 0.41050790616617 no 1361 0.392666701585168 1913 54690634 SGTC_22 0964-0034 14.468 µM 0.27120144558536 0.410936449243717 no 1362 0.393118050607436 1819 138402 SGTC_2495 cafestol 54.53 µM 0.268587407123056 0.41189108355101 no 1363 0.394123601990762 1881 16667697 An anti-infammatory. SGTC_2540 epiandrosterone 100 µM 0.268497823105808 0.4119238084821 no 1364 0.394158075142948 1876 441302 A steroid. SGTC_235 0330-0087 5 mM 0.267774033576261 0.412188230353384 no 1365 0.394436629621264 1827 46494818 YHR062C RPP1 SGTC_1949 st076024 69.1 µM 0.26572828845328 0.412935817189213 no 1366 0.395224237680452 1728 2921930 SGTC_691 1548-0686 185 µM 0.265537133955956 0.41300568790747 no 1367 0.395297853731315 1778 46495133 SGTC_482 fipronil 114 µM 0.264302642717124 0.413456984943801 no 1368 0.395773362035507 1879 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_521 r062-0005 13.8 µM 0.263356477443479 0.413802955151305 no 1369 0.396137916395228 1796 2832033 SGTC_1909 st060837 51.5 µM 0.262460704905924 0.414130560667835 no 1370 0.39648313832621 1792 678937 SGTC_2699 st077704 54.6 µM 0.260856077755839 0.414717560591484 no 1371 0.39710174862788 1850 645852 SGTC_148 3253-0744 288.01 µM 0.260604273289088 0.41480969227582 no 1372 0.397198846961421 1812 6893655 SGTC_902 1120-0002 2.07 µM 0.26047674833405 0.414856353636711 no 1373 0.397248024297005 1805 3280475 SGTC_1119 parthenolide 318.541 nM 0.260472829766979 0.414857787458809 no 1374 0.397249535436431 1909 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2012 4023501 200 µM 0.259437981902473 0.415236482798259 no 1375 0.397648663658071 1793 3477460 SGTC_3274 9138298 49.47 µM 0.258178160661151 0.41569761184641 no 1376 0.398134705985764 1953 17015756 SGTC_1628 st004252 77.7 µM 0.257693531180551 0.415875030456379 no 1377 0.398321719456223 1947 692968 SGTC_2677 mitomycin C 100 µM 0.256777339978775 0.416210486857222 no 1378 0.39867533188448 1855 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_303 1348-1668 34.2 µM 0.255935284911129 0.416518852723661 no 1379 0.399000404169432 1881 5380509 SGTC_1138 3761-0006 1.03 µM 0.255240934038712 0.416773167047001 no 1380 0.399268508505856 1897 12061087 SGTC_1525 8-methoxypsoralen 92.5 µM 0.254656288484428 0.416987327502292 no 1381 0.399494290031219 2003 4114 Related to psoralen; DNA damaging agent. SGTC_783 0848-0141 92.7 µM 0.253715330742809 0.417332059736136 no 1382 0.399857744652181 1832 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2593 nobiletin 86.24 µM 0.253532368102843 0.417399097892257 no 1383 0.399928425943399 1799 72344 An anti-infammatory. SGTC_1756 st041558 35.5 µM 0.253201155762371 0.41752046136744 no 1384 0.40005638672026 2015 3955792 SGTC_72 0744-0168 198.391 µM 0.252173227172259 0.4178971669602 no 1385 0.400453585553993 1867 677577 SGTC_2725 haloperidol 53.21 µM 0.251843009662157 0.418018197970802 no 1386 0.400581205793547 1904 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3245 9134821 49.47 µM 0.25093147452727 0.418352333234097 no 1387 0.400933544800909 1801 17014901 SGTC_134 0269-0018 6.916 µM 0.250291726213324 0.418586876649589 no 1388 0.401180877206432 1823 4378915 SGTC_202 3594-0513 34.79 µM 0.250154495447517 0.418637191727881 no 1389 0.401233937007218 1969 708429 SGTC_3156 9099931 49.47 µM 0.250105381754594 0.41865519937859 no 1390 0.401252927089312 1848 18111053 SGTC_250 brefeldin a 552.239 µM 0.248717525994295 0.419164130277295 no 1391 0.401789645494284 1876 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_836 0330-0104 1.35 µM 0.24813827659458 0.419376582845323 no 1392 0.4020137105349 1886 46494820 SGTC_657 3534-0529 86.7 µM 0.247853120077538 0.41948117896233 no 1393 0.402124026509293 1956 1049549 SGTC_2875 9039966 71.43 µM 0.244086201656269 0.420863425235396 no 1394 0.403582029444296 1973 6463691 SGTC_2222 6885208 172.143 µM 0.241714147319568 0.421734337179765 no 1395 0.404500833299027 1915 609514 SGTC_1692 fluoroquinolonic acid 71 µM 0.241684015299724 0.421745402777903 no 1396 0.404512508191953 1935 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1377 2944-0135 198 µM 0.240700955313045 0.422106452803284 no 1397 0.404893449251482 1868 1894137 SGTC_1552 6-methylflavone 10.6 µM 0.240202605592716 0.422289507535133 no 1398 0.405086596918011 1993 689013 SGTC_1243 0416-0003 5.65 µM 0.239884853490613 0.422406233585841 no 1399 0.405209761619039 1861 2141977 SGTC_1206 3978-0017 132 µM 0.239270558710001 0.422631913731394 no 1400 0.405447896591713 1935 3873677 SGTC_668 1682-0499 62.6 µM 0.238663362036461 0.422855011127952 no 1401 0.405683314341805 1869 682214 SGTC_557 1315-0110 16.2 µM 0.238358797044439 0.422966924319642 no 1402 0.405801410854987 1854 6833801 SGTC_1482 3346-2049 8.48 µM 0.23756064243326 0.423260237760924 no 1403 0.406110939721092 1964 3826804 SGTC_1046 2001-0062 216 µM 0.237356399190975 0.42333530185002 no 1404 0.406190155843059 1830 739778 SGTC_1752 st044819 83.042 µM 0.237024526061123 0.423457278791534 no 1405 0.406318881643169 1840 441209 YML126C ERG13 SGTC_362 0310-0100 9.03 µM 0.235509492451988 0.424014208586605 no 1406 0.40690665605951 1874 790235 SGTC_3261 9137475 49.47 µM 0.234636208313061 0.424335298854091 no 1407 0.407245551895368 1966 17027690 SGTC_1369 1866-0067 208 µM 0.23451775596849 0.424378855441845 no 1408 0.407291525113395 1987 3531355 SGTC_2434 5670830 169.91 µM 0.234079685001912 0.424539948297466 no 1409 0.407461558436385 1881 1549830 SGTC_812 4251-0442 148 µM 0.233446044592892 0.42477298065519 no 1410 0.407707531129908 2016 5723007 SGTC_356 1634-0012 32.5 µM 0.231199513286824 0.425599393211066 no 1411 0.408579904051574 2058 735457 SGTC_1670 st016595 4.04 µM 0.23108951914884 0.425639864253695 no 1412 0.40862262864214 2011 597879 SGTC_2425 5628681 7.85 µM 0.230513213923723 0.425851921743276 no 1413 0.408846498354942 1964 5714958 SGTC_532 1548-0774 215 µM 0.230168415859164 0.425978804027665 no 1414 0.408980451750103 2003 5932993 SGTC_3300 9124615 50.48 µM 0.229883917095885 0.4260835025355 no 1415 0.409090986986498 1965 24824903 SGTC_3036 9090181 49.47 µM 0.227566508611428 0.426936526431164 no 1416 0.40999162953466 1899 25236586 SGTC_63 0099-0242 26.702 µM 0.224463271627772 0.428079343634719 no 1417 0.411198421385698 2030 3898502 YLR359W ADE13 SGTC_1374 2889-5571 141 µM 0.223323361965261 0.42849928587246 no 1418 0.411641923070914 1877 2853281 SGTC_2263 7948595 193.29 µM 0.222581724425674 0.428772548337159 no 1419 0.4119305307227 1865 2971371 SGTC_1435 4092-0789 56.7 µM 0.221676125846022 0.42910626989243 no 1420 0.412283008276711 2003 2248285 SGTC_2811 7967822 32.47 µM 0.220299872735863 0.429613529009314 no 1421 0.412818809634761 1965 2232244 SGTC_1294 1000-1494 117 µM 0.219725509088632 0.429825262279946 no 1422 0.413042468370531 1853 712797 YDL207W GLE1 SGTC_2432 5630864 12.22 µM 0.218260054072742 0.430365578560038 no 1423 0.413613248188021 1896 5714970 SGTC_1671 st016596 74.5 µM 0.217604798262325 0.430607214976805 no 1424 0.413868522803264 1928 2829167 SGTC_2168 5727979 200 µM 0.21719938813587 0.430756729682924 no 1425 0.414026480750021 1976 695210 SGTC_1968 st069590 43.6 µM 0.216849936862456 0.430885614805703 no 1426 0.414162646888119 2015 6384066 SGTC_1449 4112-4002 201 µM 0.216776964053782 0.430912529671808 no 1427 0.414191082557416 1852 2059539 SGTC_593 1203-0218 61.7 µM 0.21443109737673 0.431777935767904 no 1428 0.415105446699324 2039 3666956 SGTC_3180 9109287 49.47 µM 0.214391684329385 0.431792478316934 no 1429 0.415120812929515 1941 18891271 SGTC_1028 k015-0029 4.8 µM 0.213128006083096 0.432258796729332 no 1430 0.415613560373071 1879 4588309 SGTC_1367 1812-0510 76.9 µM 0.212521761678156 0.432482544598229 no 1431 0.415850001076212 1976 1142582 YDR527W RBA50 SGTC_2636 apigenin dimethyl ether 100 µM 0.210712048119434 0.433150587819768 no 1432 0.416555986319992 1954 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1475 4092-1048 11.7 µM 0.209363523195083 0.433648510797606 no 1433 0.417082233004151 1944 2881759 SGTC_1172 0370-0043 85 µM 0.209345518981252 0.433655159302743 no 1434 0.41708925995334 1968 376585 SGTC_1828 st055811 49 µM 0.208588330850727 0.433934786883942 no 1435 0.417384810418109 2061 5877589 SGTC_2537 larixol 68.93 µM 0.208228657533418 0.43406762488421 no 1436 0.417525216748518 1948 6708759 SGTC_2678 equilin 100 µM 0.204999597149691 0.435260544190508 no 1437 0.418786219884808 2046 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_344 k064-0035 6.43 µM 0.202816441695131 0.436067407057547 no 1438 0.419639253198714 1856 5088750 SGTC_221 trifluoperazine 10.304 µM 0.202638342704463 0.436133241670536 no 1439 0.419708859269733 2004 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2239 6685329 187.64 µM 0.201534264571421 0.436541405560325 no 1440 0.420140419885721 1903 805680 SGTC_782 0083-0095 30.5 µM 0.199486135313327 0.437298751985166 no 1441 0.420941243909575 2002 3591729 An indicator and reagent. SGTC_2260 7964312 200 µM 0.198076023395202 0.437820309473512 no 1442 0.421492791861578 2064 231951 SGTC_1032 k061-1018 98.7 µM 0.196926713281265 0.438245484270962 no 1443 0.421942444405128 2099 4005393 SGTC_951 1171-0579 82.7 µM 0.196712691420508 0.438324667223099 no 1444 0.422026188916292 1972 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1120 ficusin 1.78878 µM 0.195031601945937 0.438946715601938 no 1445 0.422684103929431 2014 6199 A DNA cross-linker. SGTC_2912 7964298 10.93 µM 0.193747059982971 0.439422132457135 no 1446 0.423186970707043 1931 2975850 SGTC_3159 9100096 49.47 µM 0.193233047951223 0.439612395979356 no 1447 0.42338822896101 2023 25236875 SGTC_3349 9149703 23.001 µM 0.19292466108381 0.439726553257289 no 1448 0.423508985542817 2042 4910494 SGTC_761 k216-0224 480 µM 0.191226323024611 0.440355326029677 no 1449 0.424174140673956 2107 1340404 SGTC_1864 st057645 30.4 µM 0.190810909558756 0.440509146800036 no 1450 0.424336870567501 2098 688666 SGTC_1664 st014217 9.02 µM 0.190794676970478 0.440515157642762 no 1451 0.424343229620442 2108 3982782 SGTC_2020 4017018 200 µM 0.19008736854249 0.440777083554468 no 1452 0.424620334032728 1968 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_976 1348-1067 47.6 µM 0.189904482488037 0.440844812963538 no 1453 0.424691989936284 1999 5310671 YGL099W LSG1 SGTC_1159 4092-0538 61.2 µM 0.18775889033077 0.441639533091786 no 1454 0.425532831654972 1964 717301 SGTC_1145 3546-0597 10.2 µM 0.185859947136749 0.442343091415862 no 1455 0.426277296207891 1994 875334 SGTC_1121 fusaric acid 630.51 nM 0.185774072387352 0.442374912320092 no 1456 0.426310968904463 1915 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2575 plumbagin 510 nM 0.185230059500275 0.442576505025404 no 1457 0.426524296476813 1907 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_645 0845-0943 5.41 µM 0.185145978267437 0.442607664003489 no 1458 0.426557269757405 1985 1885106 SGTC_1227 3909-8010 46.6 µM 0.185073136424645 0.44263465815472 no 1459 0.426585835815873 1988 15982272 SGTC_1839 st053978 48 µM 0.183758593048125 0.443121854888244 no 1460 0.427101420431998 2087 3788398 SGTC_277 nystatin 15.5 µM 0.183536234540997 0.443204274035541 no 1461 0.427188645280901 1970 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3001 9076041 71.4286 µM 0.183107454518674 0.443363212078161 no 1462 0.427356853402037 2001 16004211 SGTC_319 1348-1596 45.5 µM 0.182791939023834 0.443480171611082 no 1463 0.427480636888163 2091 5380505 SGTC_656 4090-1979 187 µM 0.18176092403769 0.443862396412978 no 1464 0.427885175866927 2095 22330961 SGTC_2299 7976368 114.88 µM 0.180275518440947 0.444413167690517 no 1465 0.428468137119922 2071 2979718 SGTC_2149 5554786 194.827 µM 0.178829858638781 0.444949304782057 no 1466 0.429035649693598 1969 745063 YPR165W RHO1 SGTC_1998 st075797 76.8 µM 0.175260927144665 0.446273307193156 no 1467 0.430437306074881 2106 24208315 SGTC_629 3448-6466 76.7 µM 0.174968524234993 0.446381809599965 no 1468 0.430552183025236 2018 573744 SGTC_2391 6285546 200 µM 0.173361986455768 0.446978021505255 no 1469 0.431183451526562 1920 846083 SGTC_1097 itavastatin 7.23 µM 0.173312455598805 0.446996405111181 no 1470 0.431202916846528 2007 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2003 4023581 200 µM 0.172347420102433 0.447354605163428 no 1471 0.431582203105199 1966 16641307 SGTC_2005 4024620 188 µM 0.171404624400425 0.447704591764919 no 1472 0.431952809422422 2056 236743 SGTC_2711 st079103 59.1 µM 0.17130952703857 0.44773989627265 no 1473 0.431990194852976 2080 54693780 SGTC_105 0111-0055 734.78 µM 0.170331214719133 0.448103114718851 no 1474 0.432374832068463 2025 5179370 SGTC_651 3253-0966 34.4 µM 0.169762525484979 0.448314272240222 no 1475 0.432598449703802 2010 781462 SGTC_2949 9072542 2.23 µM 0.169463757926164 0.448425212192178 no 1476 0.432715938506171 1980 16457352 SGTC_1661 st013063 9.66 µM 0.169010565441654 0.448593501721779 no 1477 0.432894165466458 2016 721395 SGTC_717 1532-0246 73.2 µM 0.166622262780632 0.449480531598708 no 1478 0.433833637706052 1994 9561992 SGTC_2617 dihydrotanshinone i 20.83 µM 0.166471195915014 0.449536647272836 no 1479 0.433893074598396 2000 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_3164 9100705 49.47 µM 0.166124189873067 0.449665550821206 no 1480 0.434029608943072 2107 17174235 SGTC_1129 3453-1384 223 µM 0.16604469547277 0.449695081632461 no 1481 0.434060888227159 2035 1084452 SGTC_3000 9075062 71.4286 µM 0.165071564950638 0.45005660552223 no 1482 0.434443826917294 1990 17057871 SGTC_2552 juarezic acid 87.02 µM 0.164394264937681 0.45030825106693 no 1483 0.434710389035905 2157 1549512 SGTC_1818 st052136 56.3 µM 0.163336930004568 0.45070113552998 no 1484 0.435126579191895 2032 674169 SGTC_2469 5655019 90.81 µM 0.162948995686991 0.450845296279209 no 1485 0.435279296673381 2101 2788239 SGTC_1437 4092-1038 11.6 µM 0.162251563083446 0.451104486363092 no 1486 0.43555387811423 2032 3977136 SGTC_2488 5268135 45.7 µM 0.162200110512705 0.451123608745579 no 1487 0.43557413638782 2063 1270356 YLR208W SEC13 SGTC_1927 st060202 13.8 µM 0.16204217271455 0.451182307142679 no 1488 0.435636321841359 2132 688887 SGTC_1547 harmine 94.2 µM 0.160206200809317 0.451864733570967 no 1489 0.436359322473952 2088 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2886 9058944 51.95 µM 0.158818405231261 0.452380668430696 no 1490 0.436905973791087 2116 4949929 SGTC_2278 7948257 134.34 µM 0.157865736943242 0.452734884471432 no 1491 0.437281298707998 2161 1247028 SGTC_3221 9128209 49.47 µM 0.157583815900777 0.45283971407517 no 1492 0.437392378629026 2030 16460723 SGTC_1168 k815-0004 80.5 µM 0.157448995104435 0.452889847042191 no 1493 0.437445501216776 2025 642433 SGTC_3015 9080845 49.47 µM 0.156435903713767 0.453266587945393 no 1494 0.437844719234056 2113 5296973 SGTC_1588 farnesol 29.9 µM 0.156236888914752 0.45334060104501 no 1495 0.437923150301686 1984 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1778 st046819 58.9 µM 0.155920303344223 0.453458341755545 no 1496 0.438047920641844 2001 671715 SGTC_2345 9052315 157.45 µM 0.155855151507276 0.453482572753722 no 1497 0.438073598561716 2002 6469265 SGTC_2984 9022109 38.96 µM 0.154647164599242 0.453931873460285 no 1498 0.438549742636779 2174 6459207 SGTC_2280 7785178 200 µM 0.15448727490057 0.453991347538068 no 1499 0.438612771965117 2024 2954328 SGTC_2130 NSC 7 2.4545 µM 0.15399080284206 0.45417602652896 no 1500 0.438808493678609 2109 21448 SGTC_2857 9024691 58.44 µM 0.153188669300649 0.454474427205353 no 1501 0.439124746398863 2024 16478292 SGTC_545 4218-0007 221 µM 0.152105735462031 0.454877328774288 no 1502 0.439551770301257 2055 2840508 SGTC_2867 9039098 71.43 µM 0.151892585381066 0.454956635962286 no 1503 0.439635828223828 2070 6463460 SGTC_447 ml7 120 µM 0.151876137406811 0.454962755868473 no 1504 0.43964231476448 2163 4216 Selective myosin light chain kinase inhibitor. SGTC_1086 cerivastatin 2.18 µM 0.151583027149396 0.45507181712497 no 1505 0.439757910535608 2162 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1218 1348-1416 30.7 µM 0.151370583245409 0.455150865943912 no 1506 0.439841696610754 2058 6787668 SGTC_26 0302-0163 425.158 µM 0.149968782503514 0.455672510095157 no 1507 0.440394622315714 2045 3100915 SGTC_709 3807-1509 243 µM 0.147408668118819 0.456625387541178 no 1508 0.441404732047455 2148 1886677 YPL242C IQG1 SGTC_597 k018-0003 82.8 µM 0.147104782744511 0.456738510688765 no 1509 0.441524657433153 2104 6786234 SGTC_1030 k029-0042 36.7 µM 0.146950167263617 0.456796068572314 no 1510 0.441585676976335 2016 6080581 SGTC_677 0929-0063 136 µM 0.146918533612271 0.456807844775355 no 1511 0.44159816147896 2159 1539583 SGTC_1857 st056007 79.3 µM 0.146661475763846 0.456903540648314 no 1512 0.441699613801766 2154 619834 SGTC_2689 tacrolimus 100 µM 0.14664740299114 0.4569087796435 no 1513 0.441705167975233 2011 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_3097 9117246 49.47 µM 0.145308029185738 0.457407434288047 no 1514 0.442233837817948 2155 16423892 SGTC_1299 1079-1439 3.74 µM 0.143205925539857 0.458190191466291 no 1515 0.443063775077632 2039 323161 SGTC_1956 st077085 54 µM 0.143155117677095 0.458209112733293 no 1516 0.443083837775375 2013 24208685 SGTC_1747 st037496 66.6 µM 0.142837324318206 0.458327463747282 no 1517 0.443209329379861 2078 723305 SGTC_2810 7959871 45.46 µM 0.141919454116431 0.458669313087632 no 1518 0.443571813844703 2105 2974535 SGTC_1012 4112-3522 18 µM 0.141015544824247 0.459005992737038 no 1519 0.443928831031026 2152 3112398 SGTC_3138 9097216 49.47 µM 0.140219606092187 0.459302480880705 no 1520 0.444243240759408 2210 25237486 SGTC_2347 9049783 174.81 µM 0.140052663230779 0.459364670176565 no 1521 0.444309190569801 2110 6467988 YPL169C MEX67 SGTC_3298 9116858 71.43 µM 0.139995075356909 0.459386122952778 no 1522 0.44433194068359 2116 2506942 SGTC_823 0417-1665 178 µM 0.137839717034131 0.460189126828974 no 1523 0.445183547144065 2062 3429856 SGTC_1627 st003713 25.6 µM 0.137554147945274 0.460295531177693 no 1524 0.445296397790687 2039 16195070 YER133W GLC7 SGTC_2300 7976697 71.57 µM 0.136665074890446 0.460626822036562 no 1525 0.4456477683251 2029 2236109 SGTC_1963 st076565 50.3 µM 0.136019925429911 0.460867237988226 no 1526 0.445902764570929 2101 4914280 SGTC_1265 0819-1001 68.8 µM 0.135629068494484 0.461012898397977 no 1527 0.44605726222505 2152 3106768 SGTC_1123 mangostin 811.285 nM 0.133600151351324 0.461769097296936 no 1528 0.446859382250614 2017 5281650 An antioxidant. SGTC_1841 st054148 70 µM 0.132206984640507 0.4622884254911 no 1529 0.447410288336904 2046 675442 SGTC_638 3970-0837 4.09 µM 0.131847394670443 0.462422479658159 no 1530 0.447552499111097 2050 4118451 YLR208W SEC13 SGTC_957 1187-1561 14.1 µM 0.131501912617101 0.462551278452685 no 1531 0.447689136832303 2177 1538454 SGTC_2782 7736369 71.43 µM 0.130601950238961 0.462886810866449 no 1532 0.448045099937945 2047 2950836 YOL077C BRX1 SGTC_3240 9133527 49.47 µM 0.130446293050024 0.462944847124723 no 1533 0.448106671448651 2072 17617455 SGTC_1651 st011928 86.1 µM 0.129551962095911 0.463278310653626 no 1534 0.448460455764035 2127 720198 SGTC_3137 9097352 49.47 µM 0.129357566385459 0.463350797175319 no 1535 0.448537361312336 2129 44120435 SGTC_391 gliotoxin 8.33 µM 0.128742212158274 0.463580259259051 no 1536 0.448780816427968 2107 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_507 nimesulide 162 µM 0.128077576794636 0.463828111606392 no 1537 0.449043790505579 2173 4495 A COX2 inhibitor. SGTC_217 ketoconazole 989 nM 0.127418735782868 0.464073817010908 no 1538 0.449304494046155 2153 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.125652643047894 0.464732523568906 no 1539 0.450003445011227 2160 66535 A nucleotide analog. SGTC_2836 9010338 19.48 µM 0.125641936458429 0.464736517144313 no 1540 0.450007682739054 1997 2994051 SGTC_87 0100-0052 35.5 µM 0.124399893043042 0.465199825376831 no 1541 0.450499329015136 2163 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2862 9027634 71.43 µM 0.122911669540174 0.465755026021797 no 1542 0.451088522370686 2076 5012562 SGTC_1014 4130-3005 69.3 µM 0.122097308015234 0.466058862200101 no 1543 0.451410976910966 2033 743608 SGTC_286 k060-0067 22.9 µM 0.122032958600672 0.46608287164593 no 1544 0.45143645807094 2120 5985051 SGTC_3207 9114163 49.47 µM 0.121821041011974 0.466161941207399 no 1545 0.451520374871195 2208 849233 SGTC_76 0433-0009 400.328 µM 0.121465607070666 0.466294561822828 no 1546 0.451661127272174 2017 2841569 SGTC_2044 5102272 200 µM 0.120958710908051 0.46648370296366 no 1547 0.451861869460105 2101 592666 SGTC_1716 st033144 30.6155 µM 0.119992860786564 0.466844117206731 no 1548 0.452244401681797 2197 674617 SGTC_1289 0976-0073 69.1 µM 0.119270541808142 0.467113673756365 no 1549 0.452530510554763 2128 3391136 SGTC_246 cycloheximide 667 µM 0.119049287484826 0.467196244943877 no 1550 0.452618153817795 2088 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1776 st049249 45.9 µM 0.118463883584372 0.467414722028906 no 1551 0.452850055135519 2043 1822314 SGTC_2479 5617353 43.85 µM 0.117737425262375 0.467685855314521 no 1552 0.453137855964824 2151 2731746 SGTC_1866 st057638 64 µM 0.116765394992169 0.468048665916113 no 1553 0.453522983456831 2101 688802 SGTC_3239 9133757 49.47 µM 0.11504632972491 0.468690372351254 no 1554 0.454204199999893 2145 17036923 SGTC_2580 diallyl disulphide 81.36 µM 0.114958667667512 0.468723097739423 no 1555 0.454238941600862 2107 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2997 9067075 71.4286 µM 0.114788325462406 0.46878668930807 no 1556 0.454306451408823 2126 27209819 SGTC_2453 5731132 22.18 µM 0.1141966551807 0.46900757580784 no 1557 0.454540951672047 2184 1362040 SGTC_2305 7443522 69.23 µM 0.113626162893942 0.469220565024548 no 1558 0.454767073337679 2142 5415886 SGTC_784 4579-0127 173 µM 0.113142631444806 0.469401094933418 no 1559 0.45495873848095 2213 1948547 SGTC_701 4424-0219 185 µM 0.112591685057873 0.469606802354711 no 1560 0.455177138746472 2216 2911779 SGTC_1878 temozolomide 1 mM 0.109764682762535 0.4706624495462 no 1561 0.4562980004126 2228 5394 DNA alkylating agent. SGTC_526 4469-0568 170 µM 0.109691588781834 0.47068974675658 no 1562 0.456326985670565 2117 2901964 SGTC_353 1988-1175 58.3 µM 0.108769933479439 0.471033954023263 no 1563 0.456692485951316 2096 2788357 SGTC_2191 5911152 200 µM 0.107565166232895 0.471483926675013 no 1564 0.457170314970704 2210 2875902 SGTC_225 nsc-122657 1.016 µM 0.106247960189533 0.471975936118058 no 1565 0.4576928097684 2178 275685 SGTC_2693 st077581 40.7 µM 0.105709165398067 0.472177201832919 no 1566 0.457906554082022 2243 25238761 SGTC_1936 st074407 74.3 µM 0.105044628230909 0.472425448140097 no 1567 0.458170198188598 2178 809813 SGTC_1722 st034304 3.6505 µM 0.104325356355538 0.472694153361837 no 1568 0.458455578120756 2139 4036148 YLR033W RSC58 SGTC_973 1325-0077 65.9 µM 0.103542949712557 0.472986458544988 no 1569 0.458766031858247 2170 2835149 SGTC_2589 lobaric acid 100 µM 0.103294024761178 0.473079459347913 no 1570 0.45886480890164 2110 73157 A novel microtubule depolymerizer. SGTC_368 fentichlor 4.58 µM 0.102138169240853 0.473511317451715 no 1571 0.459323502374764 2111 7329 A pesticide. SGTC_3048 9093155 49.47 µM 0.101250959864154 0.473842823418758 no 1572 0.459675622205874 2245 25236002 SGTC_313 3474-0040 5.03 µM 0.100513204154363 0.474118499796295 no 1573 0.459968450262812 2193 1043375 YIL048W NEO1 SGTC_1234 0326-0494 15.5 µM 0.100225450807503 0.474226027645006 no 1574 0.460082670460169 2205 1547813 SGTC_1886 st057356 49.9 µM 0.0998638358412752 0.474361158810885 no 1575 0.460226213800475 2046 24207747 SGTC_2937 9044753 11.33 µM 0.0987934722734261 0.474761158037765 no 1576 0.460651125754962 2216 6465530 YGL099W LSG1 SGTC_2255 7941087 197.44 µM 0.0985145095617352 0.474865411735655 no 1577 0.460761875519368 2244 935561 SGTC_1232 0279-0259 161 µM 0.0977907078240573 0.475135918289066 no 1578 0.461049243049639 2131 1560000 SGTC_371 0195-0006 7.36 µM 0.0971651184304462 0.475369729164457 no 1579 0.461297634197802 2167 3928593 SGTC_942 3253-1115 227 µM 0.0971418220586025 0.475378436230051 no 1580 0.461306884347195 2202 46497897 SGTC_3342 9147791 14.508 µM 0.0969617497088177 0.475445739027509 no 1581 0.461378385291328 2223 1838168 SGTC_1695 st026914 34.495 µM 0.0968660778908695 0.475481497056633 no 1582 0.461416374004159 2148 3289191 SGTC_3302 9125395 16.351 µM 0.0964211305486854 0.475647801911926 no 1583 0.461593055280106 2138 17599668 SGTC_1003 4049-0218 100 µM 0.0961244336895625 0.475758698580746 no 1584 0.461710872940694 2189 295161 SGTC_1610 st001799 48.1 µM 0.0957590323300554 0.475895277575881 no 1585 0.461855977621385 2069 621897 SGTC_2807 7945238 51.95 µM 0.095567999066152 0.475966682738611 no 1586 0.461931840939905 2168 17148797 SGTC_1991 st073000 8.92 µM 0.0943931977759628 0.47640582145455 no 1587 0.462398409534454 2204 4301969 YIL048W NEO1 SGTC_1468 k284-1086 134 µM 0.0943172726064345 0.476434203144833 no 1588 0.462428564760866 2128 15996457 SGTC_1505 k297-0037 20.6 µM 0.0928426796885778 0.476985446250597 no 1589 0.463014271965437 2100 4089396 SGTC_2473 5854593 8.94 µM 0.0925130818263046 0.477108664992795 no 1590 0.463145198999968 2117 2872951 SGTC_1792 st045773 43.6 µM 0.0919655026760118 0.477313379933984 no 1591 0.463362724139712 2123 2919270 SGTC_1317 1273-0028 910 nM 0.091804327426715 0.477373637172526 no 1592 0.463426752897626 2167 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2923 7992654 58.14 µM 0.0917370396524414 0.477398793641438 no 1593 0.463453484035475 2159 2985126 SGTC_2911 7942208 15.64 µM 0.0915683688356942 0.477461853964413 no 1594 0.463520491923358 2121 1243384 SGTC_140 0062-0056 502.533 µM 0.0906448008175705 0.477807154824119 no 1595 0.463887416266057 2251 3758964 SGTC_3109 9122853 49.47 µM 0.0904503698228682 0.477879850236944 no 1596 0.463964665681581 2173 1234709 SGTC_2290 7904846 200 µM 0.0880959000142263 0.478760215919893 no 1597 0.464900227513067 2173 2962154 SGTC_1784 st039334 36.3 µM 0.0880634854000393 0.478772336882272 no 1598 0.464913109008601 2262 3496984 SGTC_2030 5175110 200 µM 0.0856392666324598 0.479678892256913 no 1599 0.465876591423856 2202 2831986 SGTC_1067 clotrimazole 1.36 µM 0.0855429534407321 0.479714911522814 no 1600 0.465914874343811 2161 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_90 0870-0863 4.608 µM 0.0849819233394089 0.479924729183956 no 1601 0.466137880900385 2244 1738164 SGTC_2404 5161160 200 µM 0.0822706452863478 0.480938787814492 no 1602 0.467215748468092 2209 2831543 SGTC_1342 1486-1464 234 µM 0.0819491508966778 0.481059039843714 no 1603 0.467343574541432 2269 3253938 SGTC_1345 1488-0192 31.4 µM 0.0817288401571991 0.481141446052064 no 1604 0.467431171971128 2254 658348 SGTC_2244 6635614 200 µM 0.0777331672176894 0.482636145307036 no 1605 0.469020155147262 2114 836499 SGTC_864 0469-0573 172 µM 0.0775472543147855 0.482705697614302 no 1606 0.469094100457142 2111 689425 SGTC_2713 st079149 53.4 µM 0.0767136964203397 0.483017548331324 no 1607 0.469425654241577 2190 3103253 SGTC_2775 cyproheptadine 69.59 µM 0.0758574272509449 0.48333790660818 no 1608 0.469766263676894 2287 2913 A selective serotonin reuptake inhibitor. SGTC_904 1141-0088 396 µM 0.0755421495426177 0.483455865021847 no 1609 0.469891681418445 2110 1378119 SGTC_550 4123-0385 25.7 µM 0.0741107182004163 0.483991440673242 no 1610 0.470461143412798 2218 5731123 SGTC_714 4296-0578 26.1 µM 0.0739121758016957 0.484065728393388 no 1611 0.470540133731028 2256 1589775 SGTC_1706 st031321 9.9705 µM 0.0736444473873976 0.484165904010461 no 1612 0.470646651618807 2277 6103185 SGTC_2796 7949634 45.45 µM 0.0734498948375889 0.484238700130175 no 1613 0.470724057222535 2238 2971588 SGTC_3247 9135149 49.47 µM 0.0716942978771233 0.484895618849591 no 1614 0.471422597060694 2290 8934436 YOR116C RPO31 SGTC_1625 st003711 30.1 µM 0.0713266137915098 0.485033206111299 no 1615 0.471568907212362 2255 24207034 YER133W GLC7 SGTC_3278 9139605 49.47 µM 0.0706730740431997 0.485277764854163 no 1616 0.471828975519201 2241 7958859 SGTC_559 1550-0661 158 µM 0.0704825989099075 0.485349042910371 no 1617 0.471904775080266 2209 5830875 SGTC_15 0266-0086 27.098 µM 0.0702484409499543 0.485436668240138 no 1618 0.471997959612194 2275 1712902 YIL048W NEO1 SGTC_1017 4239-0030 168 µM 0.0691099901302193 0.485862703113417 no 1619 0.472451034534705 2112 1149593 SGTC_652 0437-0092 114 µM 0.0684136136585057 0.486123311430894 no 1620 0.472728192544414 2274 3091274 SGTC_2018 5133068 143 µM 0.0680925275150079 0.486243475046236 no 1621 0.472855989365645 2284 785362 SGTC_2833 9001315 45.46 µM 0.0676095451599903 0.486424229218773 no 1622 0.473048228424643 2147 2989378 SGTC_348 k064-0012 10.7 µM 0.0675755282728383 0.486436960005342 no 1623 0.473061768233812 2273 5066323 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.0673826227560237 0.486509154966396 no 1624 0.473138551388131 2270 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_223 busulfan 5 mM 0.0671445823710463 0.486598242277733 no 1625 0.473233301176689 2262 2478 A DNA alkylator. SGTC_1231 0242-0792 125 µM 0.0661319179637498 0.486977242319247 no 1626 0.473636399801845 2242 3707635 SGTC_1805 st050013 60.3 µM 0.0650259866881967 0.487391161867748 no 1627 0.474076654825785 2253 4037144 SGTC_1769 st044406 64.4 µM 0.0646966943438529 0.48751440954691 no 1628 0.474207747420892 2170 670903 SGTC_2801 7907800 81.82 µM 0.0642042784066442 0.487698713415196 no 1629 0.474403785375082 2223 6620925 SGTC_2113 5491891 107.031 µM 0.0636575369509508 0.487903353582945 no 1630 0.474621458368386 2238 789979 SGTC_183 3914-0051 30.55 µM 0.0633455458903832 0.488020130323654 no 1631 0.474745674093815 2286 1596232 SGTC_1488 4013-0813 75.9 µM 0.062401283461237 0.488373569388134 no 1632 0.475121636449735 2221 2910057 SGTC_2887 9044784 58.44 µM 0.062343705617526 0.488395121173038 no 1633 0.475144562048552 2309 6465546 SGTC_2319 6033012 152.6 µM 0.0622753079372358 0.488420722941596 no 1634 0.475171795856465 2265 847246 SGTC_1409 3909-8004 61.9 µM 0.061965596713757 0.488536650788411 no 1635 0.47529511458759 2225 2119279 SGTC_936 3005-4620 401 µM 0.0615669848050346 0.488685856428491 no 1636 0.475453834676954 2298 777207 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.0615633400231612 0.488687220725255 no 1637 0.475455285981521 2250 5379071 SGTC_859 0439-0102 54.6 µM 0.0608403656700399 0.488957843513818 no 1638 0.47574317134585 2305 610143 SGTC_625 k213-0058 121 µM 0.0607080766505732 0.489007362315753 no 1639 0.4757958496552 2227 3655420 SGTC_171 k064-0041 9.68 µM 0.0603335896002001 0.489147542289588 no 1640 0.475944975015911 2211 53325 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.0589511254386436 0.489665045063036 no 1641 0.476495518306738 2315 16623 A steroid. SGTC_3304 9125678 46.087 µM 0.0578546132015985 0.490075518841431 no 1642 0.476932217973404 2278 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2738 aclarubicin 5.55 µM 0.0576707694938422 0.490144340838984 no 1643 0.477005438747763 2278 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_3143 9086658 49.47 µM 0.0566006504949207 0.490544946260197 no 1644 0.477431658178711 2192 25236626 SGTC_586 0957-0265 8.15 µM 0.0564402935516177 0.490604977668629 no 1645 0.47749552924167 2308 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2062 5245942 200 µM 0.0559522525679063 0.490787682552417 no 1646 0.477689922231667 2310 1376160 SGTC_2627 acetyl isogambogic acid 100 µM 0.0547246192618545 0.491247272498935 no 1647 0.478178927706972 2239 6857789 A caspase activator and apoptosis inducer. SGTC_2821 7996764 71.43 µM 0.0527601164525714 0.49198274872294 no 1648 0.478961519837696 2263 2987135 SGTC_211 3455-0679 143.504 µM 0.0508348051489646 0.492703578780846 no 1649 0.479728578110989 2213 748649 SGTC_2731 amoxapine 43.43 µM 0.0506866142782101 0.492759061960568 no 1650 0.479787621598637 2326 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_3072 9116419 49.47 µM 0.0501379698540982 0.492964477560642 no 1651 0.480006221102724 2283 17170162 SGTC_1702 st027038 51 µM 0.0491767335710124 0.493324374369665 no 1652 0.480389226374283 2240 5521182 SGTC_2985 9022375 71.43 µM 0.0479281822288256 0.493791852978724 no 1653 0.480886739511831 2263 4939335 SGTC_2683 piperine 63.03 µM 0.0477801260903885 0.493847288263556 no 1654 0.480945737772983 2288 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2231 micatex 6.853 µM 0.0450909467504593 0.494854192320672 no 1655 0.482017408765501 2266 20737 An antifungal of unknown mechanism. SGTC_20 0481-0013 4.944 µM 0.0418699367775584 0.49606027125597 no 1656 0.483301191174453 2318 182045 SGTC_305 1682-2595 20.8 µM 0.0418102917419291 0.496082605190064 no 1657 0.483324965282449 2277 226033 SGTC_1570 verbenone 133 µM 0.0407782971559405 0.496469034859994 no 1658 0.483736320662694 2349 29025 A natural terpanoid with antifungal properties. SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.040564093951305 0.49654924353131 no 1659 0.483821704729383 2322 688798 SGTC_351 caspofungin 25 nM 0.0401802476725309 0.496692975621366 no 1660 0.48397471249279 2276 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_3146 9095609 49.47 µM 0.0393489558851756 0.497004256120793 no 1661 0.484306087831744 2318 17173999 SGTC_768 0384-0033 77.3 µM 0.0384883960819461 0.497326498063625 no 1662 0.484649141607595 2271 3965305 YMR134W ERG29 SGTC_632 0781-2353 4.65 µM 0.0378326771082048 0.497572037272615 no 1663 0.484910545224849 2303 6811515 YHR007C ERG11 SGTC_582 0987-0078 156 µM 0.0375573011598792 0.497675154276354 no 1664 0.48502032631094 2340 1625765 SGTC_1788 fluconazole 20 µM 0.0374892252889605 0.497700645923487 no 1665 0.485047465541439 2225 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_3325 9138760 55.175 µM 0.0369405012860569 0.497906121096929 no 1666 0.485266223207482 2324 43844959 SGTC_1999 st074831 12.5 µM 0.0364559926988078 0.498087550631311 no 1667 0.485459384051683 2252 17112523 SGTC_2154 5570129 200 µM 0.0363307130445971 0.498134463032542 no 1668 0.485509330315318 2339 673366 SGTC_1743 st037606 46.3785 µM 0.0363094852812016 0.498142412014221 no 1669 0.485517793383786 2318 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2421 5690543 90.72 µM 0.035911500972171 0.498291441977809 no 1670 0.485676462667006 2284 3397993 SGTC_627 1391-0720 175 µM 0.0353162382986735 0.498514345612693 no 1671 0.485913787558932 2302 997839 SGTC_2406 ethylparaben 405.7 µM 0.0351425152267086 0.498579398504157 no 1672 0.485983050042849 2260 8434 A possible steroid mimic. SGTC_430 0958-0115 16.4 µM 0.0346456717610307 0.498765448283699 no 1673 0.486181141271577 2202 6833180 SGTC_2685 mycophenolic acid 18.85 µM 0.0345887243168834 0.498786773045041 no 1674 0.486203846406375 2333 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2594 a-mangostin 100 µM 0.0340202434476606 0.498999648781551 no 1675 0.486430504053325 2327 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_68 0986-0284 82.829 µM 0.0326205081397827 0.49952380063838 no 1676 0.486988607700889 2148 423278 YIL048W NEO1 SGTC_2323 6148992 148.28 µM 0.0325903584381196 0.49953509065816 no 1677 0.487000629299758 2319 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2651 TUB2.036 5 µM 0.0319810712969458 0.499763247672253 no 1678 0.487243573046201 2330 15992207 YFL037W TUB2 SGTC_1772 st048439 82.2 µM 0.0307165903408271 0.499763247672253 no 1679 0.48774778011336 2280 2927068 YDL195W SEC31 SGTC_1108 betulinic acid 729.144 nM 0.0305153718592336 0.499687898280668 no 1680 0.487828017059736 2344 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_330 1488-0319 80.1 µM 0.0294960202368038 0.499306186430595 no 1681 0.488234496476531 2277 6846614 SGTC_2268 7933382 153.85 µM 0.0293534896133093 0.499252813695091 no 1682 0.488291333357974 2365 935025 YOR257W CDC31 SGTC_245 methotrexate 289.6 µM 0.0273053518706181 0.498485859662129 no 1683 0.489108094142983 2288 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_3210 9128157 49.47 µM 0.0271578995192115 0.498430644233869 no 1684 0.489166897313127 2224 17590849 SGTC_2783 7738165 71.43 µM 0.0269495237942848 0.498352615316826 no 1685 0.489249996783905 2321 17201110 SGTC_3177 9107506 49.47 µM 0.0263249403488571 0.498118732561468 no 1686 0.489499081140278 2361 8897194 SGTC_700 3453-2283 142 µM 0.0262999764959422 0.498109384560513 no 1687 0.489509036829702 2333 565664 SGTC_75 0159-0059 199.013 µM 0.0260329743513701 0.498009402612038 no 1688 0.489615518814294 2350 5377270 SGTC_2754 granisetron 64.02 µM 0.0260196294477861 0.498004405466406 no 1689 0.489620840857764 2347 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2657 nystatin 74.44 µM 0.0259865932161336 0.497992034688178 no 1690 0.489634015952354 2344 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2894 9048625 32.47 µM 0.0252215541673396 0.497705558014514 no 1691 0.489939122342163 2358 4092861 SGTC_1062 mesoridazine 14.2 µM 0.0248726811660735 0.497574919345295 no 1692 0.49007825888109 2356 4078 A neuroleptic. SGTC_3324 9138759 60.749 µM 0.0244773927408466 0.497426900313308 no 1693 0.490235908145569 2319 45595710 SGTC_3091 9116372 49.47 µM 0.0233350524988531 0.496999143590648 no 1694 0.490691505734622 2303 17169793 SGTC_2371 9071574 200 µM 0.0227754673701006 0.496789604533365 no 1695 0.490914688575308 2373 45596039 SGTC_514 4466-0038 2.65 nM 0.0200839241919968 0.495781758019681 no 1696 0.491988212098206 2279 5722064 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.0196032984108569 0.495601790670312 no 1697 0.492179916294217 2368 6708561 SGTC_573 3702-0553 84.7 µM 0.0195906276963652 0.495597046211633 no 1698 0.492184970207403 2367 1222756 SGTC_3110 9122132 49.47 µM 0.0190671041646853 0.495401017111093 no 1699 0.492393786865467 2358 918317 SGTC_636 0kpi-0074 126 µM 0.0190094938685494 0.495379445474307 no 1700 0.492416765883551 2354 616434 SGTC_2407 paclitaxel 400 µM 0.0179926381823084 0.494998695650689 no 1701 0.492822363170612 2301 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3075 9116269 49.47 µM 0.0179629288398517 0.49498757139863 no 1702 0.492834213568258 2345 17015205 YNL244C SUI1 SGTC_1329 1447-1697 50.6 µM 0.016994023925554 0.494624780550985 no 1703 0.493220691650662 2318 2840515 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.0169372317788811 0.494603515780915 no 1704 0.493243345178716 2371 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_331 k048-0133 24.5 µM 0.0149784489010971 0.493870095519408 no 1705 0.494024686870187 2381 6813582 SGTC_603 3794-0023 45.9 µM 0.0131289073583813 0.49317759708797 no 1706 0.494762474223523 2383 3802260 SGTC_295 k015-0027 31 µM 0.0127968350208776 0.493053265921222 no 1707 0.494894940788451 2362 3887424 SGTC_1814 st052110 31.539 µM 0.0118580753655698 0.492701788713947 no 1708 0.495269423236929 2374 674163 SGTC_3327 9140648 26.9345 µM 0.0108403469861466 0.492320751555622 no 1709 0.495675411952477 2378 8029710 SGTC_2900 5328528 85.29 µM 0.00972486698063159 0.491903124283444 no 1710 0.49612040054116 2379 795359 SGTC_3320 9137005 35.139 µM 0.00971617128673049 0.491899868715725 no 1711 0.496123869457225 2371 4908713 SGTC_2650 prasterone 100 µM 0.00893644029576716 0.491607948625929 no 1712 0.496434923580945 2387 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1071 trifluoperazine 6.31 µM 0.00848649715571116 0.491439498408455 no 1713 0.496614418110755 2377 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2778 tioconazole 65.09 nM 0.00842212334525442 0.491415398193225 no 1714 0.496640098627714 2378 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2974 9094440 9.66 µM 0.00725528989256012 0.490978565545577 no 1715 0.497105583498621 2374 25236134 SGTC_2150 5556613 200 µM 0.00645967028174575 0.490680712053035 no 1716 0.497422982329187 2385 743190 SGTC_1701 st028638 40.4 µM 0.00529104390498068 0.490243226715561 no 1717 0.497889188727592 2397 3490878 SGTC_203 k066-0004 30.888 µM 0.0048201491015343 0.490066946483013 no 1718 0.498077046171828 2392 6795412 SGTC_170 4197-0004 226 µM 0.00379693867840185 0.489683912738094 no 1719 0.498485244264736 2383 218692 SGTC_1305 1181-0477 144 µM 0.00270584329441716 0.489275477084991 no 1720 0.49892052602296 2399 6252086 SGTC_2996 9066192 71.4286 µM 0.000317677675947851 0.488381541934042 no 1721 0.499873264945656 2403 6472854 SGTC_1907 st060210 83.7 µM 5.68728366755369e-05 0.4882839212489 no 1722 0.499977311020856 2401 688793 SGTC_3040 9091894 49.47 µM 0 0.488262633526488 no 1723 0.5 2392 25236966 SGTC_127 0180-0333 59.125 µM -4.49771806071747e-07 0.488262465175297 no 1724 0.49999982056701 2406 771601 SGTC_56 0957-0365 83.25 µM -0.00127182071217746 0.48778659497001 no 1725 0.499492617081606 2403 6752360 SGTC_476 mead acid 10 µM -0.00127644425385166 0.487784864424004 no 1726 0.499490772556845 2410 5312531 An omega 9 fatty acid. SGTC_422 cantharidin 155 µM -0.00205528767294029 0.487493354329128 no 1727 0.499180059426143 2410 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2991 9074669 71.4286 µM -0.0020733184311093 0.487486605749467 no 1728 0.499172866209688 2411 17333109 SGTC_926 2268-1401 59.4 µM -0.00219693436608899 0.487440338685424 no 1729 0.499123550699134 2411 2931578 SGTC_950 1165-0508 94.1 µM -0.00248318440263122 0.487333201458918 no 1730 0.499009353769845 2412 6148369 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.00318000653569813 0.487072399771826 no 1731 0.498731363079127 2412 140250 A respiratory chain inhibitor. SGTC_2758 dehydroepiandrosterone 69.35 µM -0.00328792884910549 0.487032007859027 no 1732 0.498688308530476 2420 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1527 coumarin 137 µM -0.00335653426286857 0.487006331088936 no 1733 0.498660939081308 2419 323 A hepatotoxic, DNA x-linker. SGTC_192 3455-0609 60.9 µM -0.00366459642378432 0.48689103412928 no 1734 0.498538040818119 2422 3769639 SGTC_3151 9099821 49.47 µM -0.00380733100664146 0.48683761390674 no 1735 0.498481098355576 2420 17174189 SGTC_672 1441-0018 53.7 µM -0.00427524039234602 0.486662494563588 no 1736 0.498294431044255 2419 251141 SGTC_931 2812-0076 566 µM -0.00461827580867 0.486534112071145 no 1737 0.498157581066699 2415 3450959 SGTC_403 arphamenine a 50 µM -0.00471573437085432 0.486497638035519 no 1738 0.498118701149094 2415 5487158 An arginine aminopeptidase inhibitor. SGTC_759 3486-0358 89.3 µM -0.0051053583851013 0.486351821705089 no 1739 0.497963265531392 2415 875103 SGTC_1011 4112-3381 17.4 µM -0.00548460496595176 0.486209890869256 no 1740 0.497811970157436 2465 2877139 SGTC_2215 7188065 200 µM -0.00572004145060498 0.486121781006469 no 1741 0.497718046063539 2414 940217 SGTC_1684 st024538 14.6195 µM -0.00588377875995702 0.486060504276563 no 1742 0.497652725427458 2413 6732859 SGTC_707 0865-0008 204 µM -0.00645945969489673 0.485845065193662 no 1743 0.497423066339432 2417 723043 SGTC_474 dl-dihydrosphingosine 5 µM -0.00720308365667707 0.4855667823305 no 1744 0.497126410229191 2446 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1182 1222-0449 220 µM -0.00747533626574176 0.48546490028036 no 1745 0.497017800077949 2421 658318 SGTC_1673 st016611 27.3 µM -0.00806019515085133 0.48524603829543 no 1746 0.496784482183031 2431 5226799 SGTC_1271 0832-2808 169 µM -0.00811672981125437 0.485224882507006 no 1747 0.496761928854459 2426 3663794 SGTC_3202 9113761 49.47 µM -0.00834292271811495 0.485140239463407 no 1748 0.496671693996435 2432 4798415 SGTC_1407 3909-7909 12.3 µM -0.00876636522521109 0.484981785976564 no 1749 0.496502771059464 2430 4411780 SGTC_288 1315-0019 35.1 µM -0.00913029064422772 0.484845605860823 no 1750 0.496357591636268 2428 6811474 SGTC_565 1418-0001 44.5 µM -0.00951379051677247 0.484702102939275 no 1751 0.496204603971011 2431 2862145 SGTC_1252 0493-0875 34.8 µM -0.00998579505074764 0.484525484925539 no 1752 0.496016310357278 2427 3960963 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.0103867624799198 0.484375450464544 no 1753 0.495856355796468 2423 17037758 SGTC_1832 st054113 55 µM -0.0122148213475039 0.483691453613902 no 1754 0.495127112491212 2424 1251267 SGTC_619 1652-1634 108 µM -0.0129431934719526 0.483418935035828 no 1755 0.494836557049737 2432 5400454 SGTC_678 1218-2179 85.9 µM -0.0129885657629898 0.483401959363491 no 1756 0.494818457645931 2436 6820081 YOR116C RPO31 SGTC_868 0527-0199 213 µM -0.0160141892347807 0.482270016457656 no 1757 0.4936115358872 2456 2849450 SGTC_930 2810-3379 265 µM -0.0170185231268908 0.481894307316343 no 1758 0.493210919296663 2435 1015764 SGTC_325 2810-4341 181 µM -0.0174743886792274 0.481723778821772 no 1759 0.493029082300062 2436 774970 SGTC_3225 9130819 49.47 µM -0.0180786778518736 0.481497733729481 no 1760 0.492788043890868 2445 4547121 SGTC_2522 biochanin a 4.94 µM -0.018620110698317 0.481295206212241 no 1761 0.492572079799706 2447 5280373 A possible chelator. SGTC_2014 4013930 200 µM -0.0197943809392983 0.48085597719536 no 1762 0.49210370018374 2441 64556 SGTC_463 ikarugamyin 104 µM -0.0198057453571486 0.480851726513038 no 1763 0.492099167325591 2439 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_265 mycophenolic acid 32.932 µM -0.0198847199639014 0.480822187359733 no 1764 0.492067667219393 2452 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2808 7946468 45.46 µM -0.0202592620234614 0.480682097496561 no 1765 0.491918276653546 2460 2970879 SGTC_1977 st070720 65.3 µM -0.020602395008019 0.480553757654658 no 1766 0.491781414966175 2495 682188 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.0209332257536524 0.48043002104914 no 1767 0.491649461053745 2444 688664 SGTC_284 0988-0104 32.6 µM -0.0212389657967144 0.480315670490628 no 1768 0.491527515537162 2449 4666532 SGTC_2680 butyl paraben 22.24 µM -0.0214292180543521 0.480244514609614 no 1769 0.491451633138417 2443 7184 An antifungal and steroid mimetic. SGTC_2189 6047310 154.431 µM -0.0217429793365221 0.480127166732062 no 1770 0.491326489656823 2427 711535 SGTC_3068 9116768 49.47 µM -0.0238113947943095 0.479353615291262 no 1771 0.490501525447876 2475 41904888 SGTC_2151 5563267 85.4165 µM -0.0258196931734268 0.478602620965467 no 1772 0.489700577101806 2457 5310824 SGTC_3322 9139058 2.11 µM -0.0258688834197602 0.478584227431927 no 1773 0.489680959585393 2545 4908926 YPR165W RHO1 SGTC_803 4488-1585 147 µM -0.0262689895925471 0.478434618854153 no 1774 0.489521394546054 2442 747204 SGTC_1235 benzylparaben 21.5 µM -0.0268423174672435 0.478220244139768 no 1775 0.48929275045387 2469 7180 SGTC_1727 st034309 9.9045 µM -0.0276101538823342 0.477933150045724 no 1776 0.488986541563425 2476 870305 SGTC_1987 st072290 61.9 µM -0.0283130559806803 0.477670344933222 no 1777 0.488706233804101 2500 54697379 SGTC_2933 9026794 32.47 µM -0.0290992606481326 0.477376405682848 no 1778 0.488392712733397 2484 17586027 SGTC_999 SEC7.066 22.7 µM -0.0310159156715025 0.476659875542656 no 1779 0.487628423454419 2482 740511 YDR170C SEC7 SGTC_3175 9106517 49.47 µM -0.0312318337096572 0.47657916054782 no 1780 0.487542326331117 2485 41468073 SGTC_3205 9113483 49.47 µM -0.031241031037267 0.476575722402241 no 1781 0.487538658917878 2481 17018033 SGTC_93 0109-0045 59.227 µM -0.0314054974413691 0.476514241855457 no 1782 0.487473078495556 2446 88733 SGTC_773 4358-1457 44.6 µM -0.0315685232049957 0.476453300398139 no 1783 0.487408072858039 2461 1186886 SGTC_2800 7887935 81.82 µM -0.0316761908174818 0.476413052943684 no 1784 0.487365141165853 2491 2961002 SGTC_1789 tunicamycin 25 nM -0.0322169503076638 0.476210914159949 no 1785 0.487149519402388 2522 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2449 5812982 45.77 µM -0.0334318944118586 0.475756783975369 no 1786 0.486665087904579 2452 776185 SGTC_604 1000-0114 314 µM -0.0338131177839183 0.475614294137624 no 1787 0.486513087724437 2472 1572745 SGTC_151 3013-0144 2.285 µM -0.0343957987057902 0.475396511555357 no 1788 0.486280766819154 2542 906558 YHR107C CDC12 SGTC_1460 k062-0059 9.15 µM -0.0345420624676712 0.475341845223308 no 1789 0.486222450673709 2424 1373085 SGTC_2354 9060492 162 µM -0.0347857726011505 0.475250759174197 no 1790 0.486125282792922 2474 6471895 SGTC_2316 5844804 197.44 µM -0.036090355927426 0.474763196549957 no 1791 0.485605156087413 2475 776813 SGTC_2171 5739187 198.077 µM -0.0386187555409241 0.473818364657918 no 1792 0.484597174343654 2469 2262761 SGTC_727 3032-0951 202 µM -0.0389345360292688 0.473700371601975 no 1793 0.484471290832638 2507 3652836 SGTC_1856 st057054 55.7 µM -0.040171716757108 0.473238114778871 no 1794 0.483978113090066 2499 1266018 SGTC_2121 5257820 149.641 µM -0.0402811818318893 0.473197216273938 no 1795 0.483934478162122 2475 791256 SGTC_2551 apiole 73.87 µM -0.0412091889912056 0.472850504245194 no 1796 0.48356456407066 2471 10659 A possible DNA adduct former. SGTC_2570 licareol 100 µM -0.0415730615039159 0.472714563719444 no 1797 0.483419524237644 2548 443158 SGTC_102 gallobenzophenone 83.616 µM -0.0418416264884498 0.472614231535733 no 1798 0.483312475456914 2484 70837 SGTC_408 cantharidin 100 µM -0.0424065814584544 0.472403177810472 no 1799 0.483087290912749 2525 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1499 4480-0877 67.3 µM -0.042713452483198 0.472288541345751 no 1800 0.482964977913142 2476 2861909 SGTC_473 2-arachidonoylglycerol 10 µM -0.0427144921211327 0.472288152976657 no 1801 0.482964563535798 2461 5282280 An endocannabinoid. SGTC_1383 3049-0032 20.7 µM -0.0429782575681164 0.472189621114644 no 1802 0.482859432891535 2506 712864 SGTC_2186 6124449 200 µM -0.0444720146240718 0.47163164754578 no 1803 0.482264079497041 2509 3834182 YLR033W RSC58 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.0447480990838507 0.471528525841248 no 1804 0.482154047273119 2474 756377 SGTC_2283 7944793 200 µM -0.0455834345708813 0.471216527106844 no 1805 0.481821136372134 2508 2970533 SGTC_2270 7924575 90.91 µM -0.0459761124533811 0.471069867572724 no 1806 0.481664644635907 2520 1262135 SGTC_233 rapamycin 362 pM -0.0463050817321776 0.47094700530403 no 1807 0.481533544509649 2500 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2484 5809818 12.04 µM -0.0470153607870854 0.47068174227111 no 1808 0.481250492464574 2525 2870548 SGTC_965 1291-5240 308 µM -0.0470329224471359 0.470675183803038 no 1809 0.481243494117761 2512 2834598 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.0470699280655014 0.470661363941559 no 1810 0.481228747344495 2505 165506 SGTC_2124 5246320 200 µM -0.0471651716878787 0.470625795081716 no 1811 0.481190792790756 2555 579342 SGTC_1220 1838-0075 193 µM -0.0472576453721338 0.470591260883237 no 1812 0.481153942219622 2506 5529645 SGTC_2720 fluspirilene 36.88 µM -0.0477783757889308 0.470396798802829 no 1813 0.480946435245668 2540 3396 An atypical antipsychotic. SGTC_1740 st038286 13.222 µM -0.0491355417128892 0.469890010713518 no 1814 0.480405639706133 2540 716786 SGTC_2144 5628481 200 µM -0.0495247358857779 0.469744688167227 no 1815 0.480250562498388 2491 2818399 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.0498758177705874 0.469613599955632 no 1816 0.480110673968661 2600 5282309 SGTC_819 1013-0258 27.7 µM -0.050481521461888 0.469387447892602 no 1817 0.479869337182637 2499 5753198 SGTC_1074 carmofur 3.8 µM -0.051504556814749 0.469005498843646 no 1818 0.479461735429826 2507 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2635 hydroquinidine 100 µM -0.0516050142498302 0.468967994710347 no 1819 0.479421711936107 2509 442912 An experimental heart treatment. SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.053374157680583 0.468307559495754 no 1820 0.47871689751941 2487 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2246 7293507 91.5585 µM -0.0534057338113621 0.468295772663549 no 1821 0.478704318406868 2543 887656 SGTC_2515 chrysin 20.77 µM -0.0536151556628292 0.468217599754586 no 1822 0.478620890703667 2548 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1962 st076595 64.5 µM -0.0539362349478655 0.468097749782166 no 1823 0.478492983678216 2514 279619 SGTC_2332 7982454 138.89 µM -0.0543115589979387 0.467957655413022 no 1824 0.478343470199234 2482 2981748 SGTC_2393 9031399 185.94 µM -0.0558645348498687 0.467378030235308 no 1825 0.477724861889137 2551 1526623 YDL150W RPC53 SGTC_748 act1.228 77.9 µM -0.0573077888996254 0.466839419070913 no 1826 0.477150007953609 2509 4421505 YNR035C ARC35 SGTC_457 grayanotoxin iii 135 µM -0.0576391673069271 0.466715759766974 no 1827 0.477018025259499 2561 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2362 9071156 126 µM -0.0590949027573277 0.466172566352815 no 1828 0.476438259279417 2556 653133 SGTC_2426 5582046 32.21 µM -0.0601818017909514 0.465767041660744 no 1829 0.476005419753822 2564 2251934 SGTC_2313 7726885 200 µM -0.0607096677339861 0.465570106381132 no 1830 0.475795216073385 2566 726423 SGTC_382 3229-0966 23.2 µM -0.0607220983038976 0.465565468907822 no 1831 0.475790266125681 2563 5722370 SGTC_985 1493-0307 8.71 µM -0.062264627824424 0.464990033839853 no 1832 0.475176048352397 2532 3278274 SGTC_847 0342-0274 5.54 µM -0.0623162109060802 0.464970792215781 no 1833 0.475155509565087 2527 18097 SGTC_1574 spiramycin 23.7 µM -0.0624375428871015 0.464925533041056 no 1834 0.475107199184223 2504 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1691 st019933 84.6 µM -0.0629513088106226 0.464733893454134 no 1835 0.474902638654543 2501 6176082 SGTC_2505 galangin 7.89 µM -0.0636564447517464 0.46447088435334 no 1836 0.474621893210897 2519 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_38 0929-0051 58.268 µM -0.0644781280757552 0.464164423762294 no 1837 0.474294761066551 2568 1379719 SGTC_2941 9056145 11.23 µM -0.0661577602387584 0.46353804308865 no 1838 0.47362611275399 2523 2119517 SGTC_206 4546-0025 72.014 µM -0.0676831950031512 0.462969245104868 no 1839 0.473018913537979 2547 6620745 YIL048W NEO1 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.0677416320404643 0.462947456835444 no 1840 0.472995653916568 2576 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1128 3448-9350 235 µM -0.069433545935641 0.462316674620792 no 1841 0.472322263773611 2639 619386 SGTC_1765 st044815 90.4 µM -0.0698732131017622 0.462152772608281 no 1842 0.472147286926635 2592 645695 SGTC_478 N-arachidonylglycine 10 µM -0.070013056596347 0.462100642178122 no 1843 0.472091633739542 2534 5283389 SGTC_2259 7964009 200 µM -0.0709374815997233 0.461756054271231 no 1844 0.47172375624928 2682 313134 SGTC_467 ro 31-8220 72.8 µM -0.0710341707171295 0.461720014168874 no 1845 0.471685279935364 2559 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1277 0873-0036 22 µM -0.0736883927759604 0.460730797690905 no 1846 0.470629167450732 2603 5965735 SGTC_1344 1488-0097 29.1 µM -0.0746696776491199 0.460365138477122 no 1847 0.470238767015157 2613 747966 SGTC_2714 st079313 56.9 µM -0.0747782746234159 0.460324673705253 no 1848 0.47019556387523 2538 2939799 SGTC_3008 9078912 71.4286 µM -0.0750588436654788 0.460220131606523 no 1849 0.470083946703995 2571 16648731 SGTC_3270 9137563 49.47 µM -0.0753808528588946 0.460100151990577 no 1850 0.469955846532735 2675 17015724 SGTC_3212 9128307 49.47 µM -0.0758630813645514 0.459920481958607 no 1851 0.469764014493015 2576 27243542 SGTC_3264 9137442 49.47 µM -0.0764750534989379 0.459692483473946 no 1852 0.46952058013304 2569 17015726 SGTC_1256 0570-0116 285 µM -0.0785454080145221 0.458921243645748 no 1853 0.468697105696654 2572 410638 SGTC_1363 1636-0063 10.4 µM -0.0793203644957056 0.458632599696312 no 1854 0.468388904404294 2552 6072185 SGTC_530 4358-1714 28 µM -0.0795330045838665 0.458553402572084 no 1855 0.468304340443934 2662 1564641 SGTC_1005 4092-0690 4.4 µM -0.0797280842401365 0.458480747221759 no 1856 0.468226761277119 2581 1529343 SGTC_10 0279-0212 42.575 µM -0.0797638816199277 0.458467415017621 no 1857 0.468212525526407 2565 39851 YBR002C RER2 SGTC_365 0121-0052 13.6 µM -0.0806235014406252 0.458147276408011 no 1858 0.467870687798495 2610 3101739 SGTC_3237 9133362 49.47 µM -0.080794742013784 0.45808350642987 no 1859 0.467802594832886 2542 43845137 SGTC_716 1683-5115 658 µM -0.0828511330216124 0.45731779129708 no 1860 0.466984955290199 2536 723597 SGTC_774 k060-0086 136 µM -0.0831339774236932 0.457212484045905 no 1861 0.466872504634227 2551 5911235 SGTC_585 0kpi-0023 191 µM -0.0864436877482978 0.455980454011222 no 1862 0.46555685954049 2596 64601 SGTC_1594 piperine 70.1 µM -0.0876970282826774 0.455514011462286 no 1863 0.465058740805923 2580 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1974 st069448 26.9 µM -0.0877113864338398 0.455508668294368 no 1864 0.465053034720297 2601 6323587 YNR016C ACC1 SGTC_2282 7944268 200 µM -0.0898846226967046 0.454700024767546 no 1865 0.464189450497228 2628 2970414 SGTC_541 4513-1321 94 µM -0.0901390061711908 0.454605382953648 no 1866 0.464088376461904 2577 747515 SGTC_1199 1638-0010 4.46 µM -0.0903028817884643 0.454544415398197 no 1867 0.464023265086904 2559 3111136 SGTC_788 1182-0090 188 µM -0.0904778725299594 0.454479313803694 no 1868 0.46395373849323 2784 5715185 SGTC_2670 beta-carotene 100 µM -0.0913690955642671 0.454147772182111 no 1869 0.463599658587794 2572 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.091910958401068 0.453946210763446 no 1870 0.463384392386423 2563 2724278 An inhibitor of dopamine biosynthesis. SGTC_215 1287-0124 461.5 µM -0.0934853521619203 0.4533606373427 no 1871 0.462758993006319 2643 5560863 SGTC_2064 5220758 200 µM -0.0936212152819258 0.453310109717197 no 1872 0.46270502813704 2693 788518 SGTC_1075 aripiprazole 15.2 µM -0.0948438034033207 0.452855462115507 no 1873 0.46221944679144 2563 60795 An atypical antipschotic. YIL048W NEO1 SGTC_280 3448-3607 3.04 µM -0.0953602953570123 0.452663411198992 no 1874 0.462014326013611 2573 626179 SGTC_2281 7943571 200 µM -0.0956433561366878 0.452558163368651 no 1875 0.461901914900026 2618 1244024 SGTC_933 2914-0560 114 µM -0.0968486618187197 0.452110043284922 no 1876 0.46142328949717 2586 463887 SGTC_2429 5902844 64.44 µM -0.0971763905861137 0.451988207671439 no 1877 0.46129315843868 2694 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2823 7987624 58.44 µM -0.0986957412968049 0.451423436961987 no 1878 0.460689925155059 2676 2239440 SGTC_1889 st059080 5.18 µM -0.101653630505555 0.450324217949082 no 1879 0.459515804450551 2567 176925 Isolated from Daphnopsis sellowiana. SGTC_2884 9058502 51.95 µM -0.101707980062947 0.450304023953966 no 1880 0.45949423391166 2659 6471554 SGTC_3208 9114115 49.47 µM -0.102877246995273 0.449869605098033 no 1881 0.459030198067822 2664 650895 SGTC_1901 st060216 58.6 µM -0.102972652901953 0.449834161494297 no 1882 0.458992337687729 2592 688792 SGTC_2032 5185112 25.99 µM -0.10352208597854 0.449630053121501 no 1883 0.458774310793876 2659 5718189 SGTC_3252 9135871 49.47 µM -0.104054522153925 0.449432271624431 no 1884 0.458563040467519 2713 17682838 SGTC_2647 atorvastatin 60.16 µM -0.109086447844878 0.447563713603786 no 1885 0.456566961895966 2669 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_324 1315-0088 19.6 µM -0.109163494964977 0.447535111820033 no 1886 0.456536407012608 2592 6787421 SGTC_480 am 92016 50 µM -0.109786126923957 0.44730398556419 no 1887 0.456289496821467 2660 2129 K+ channel blocker. SGTC_3184 9108758 49.47 µM -0.109797444976962 0.447299784372425 no 1888 0.456285008703689 2574 902885 SGTC_85 0868-0259 160.055 µM -0.110334923998681 0.447100282276799 no 1889 0.456071880495225 2668 83173 SGTC_94 0334-0113 514.748 µM -0.111778569647144 0.446564494583194 no 1890 0.455499489981889 2610 6795178 SGTC_2440 5628896 157.78 µM -0.113277243675053 0.446008387112615 no 1891 0.454905379009415 2625 5522048 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.113551029645373 0.445906805797209 no 1892 0.454796854422866 2618 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1831 st055328 12 µM -0.113851683698978 0.445795259853881 no 1893 0.454677683624553 2623 1103068 SGTC_2358 9037157 4 µM -0.115145314850241 0.445315357596399 no 1894 0.454164971342647 2686 2388925 SGTC_601 0986-0029 62.9 µM -0.116745237546508 0.444721940337835 no 1895 0.453530970489393 2633 24747981 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.117772737118011 0.444340902174443 no 1896 0.45312386590453 2687 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2511 berberine 10.47 µM -0.118266326521294 0.44415787764104 no 1897 0.452928318827048 2653 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_282 k297-0036 65.7 µM -0.119391485233455 0.443740709755667 no 1898 0.452482603422245 2734 5061378 SGTC_1868 st057644 42.7 µM -0.121418175237388 0.442989444458503 no 1899 0.451679910812874 2604 688665 SGTC_266 formosanin C 406 nM -0.121749477684611 0.442866654745972 no 1900 0.451548713572196 2637 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1920 st075728 45.7 µM -0.121954630401115 0.44279062231052 no 1901 0.451467474837323 2646 3400306 SGTC_2348 9022543 33.42 µM -0.122464866078903 0.442601531050051 no 1902 0.451265434659626 2724 3162678 YDL140C RPO21 SGTC_1767 st044992 70.3 µM -0.123690008210008 0.442147551842653 no 1903 0.450780361599477 2659 9600693 SGTC_1353 1498-1206 8.11 µM -0.123758930745245 0.442122014691801 no 1904 0.450753075134506 2622 6756808 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.124589433312291 0.441814316146482 no 1905 0.450424297103666 2669 6857784 SGTC_2147 5545932 89.7195 µM -0.125086869267053 0.441630034515528 no 1906 0.450227389226886 2650 797404 SGTC_2601 securinine 100 µM -0.125477511449636 0.441485324883673 no 1907 0.450072763790357 2658 442872 A GABA receptor antagonist. SGTC_2662 daunorubicin 22.37 µM -0.126011722067139 0.441287444356471 no 1908 0.449861322837506 2591 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2645 abamectin 100 µM -0.126643753993197 0.441053348114629 no 1909 0.449611182524985 2650 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2819 7996655 46.38 µM -0.1267829026885 0.441001812047 no 1910 0.449556114103231 2714 6456960 SGTC_1451 4152-0210 104 µM -0.126801323114401 0.440994989806263 no 1911 0.449548824249372 2630 659563 SGTC_641 4092-0595 30 µM -0.1268701509171 0.440969498702673 no 1912 0.449521585908087 2681 786260 SGTC_2390 9097792 176.6 µM -0.126874054159863 0.440968053102822 no 1913 0.449520041221726 2643 4497149 SGTC_2860 9025725 38.96 µM -0.12720861461273 0.440844148659146 no 1914 0.449387643650227 2642 40546248 SGTC_1076 itraconazole 331 nM -0.127294680698753 0.44081227502533 no 1915 0.449353585123507 2623 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_959 1222-0044 107 µM -0.12781157333206 0.440620857564427 no 1916 0.44914904549561 2656 6083612 SGTC_969 1313-0238 134 µM -0.127969995966937 0.440562192724182 no 1917 0.449086358764168 2646 5212874 SGTC_2946 9065502 71.43 µM -0.128451476044872 0.440383905811516 no 1918 0.448895848263197 2616 16489101 SGTC_833 3852-0053 558 µM -0.129379352027098 0.440040357397677 no 1919 0.448528742524263 2772 3123681 SGTC_51 1013-0126 23.419 µM -0.13032359019356 0.439690797184822 no 1920 0.448155208477166 2673 1627850 SGTC_1208 2323-2347 50.3 µM -0.130576702534984 0.439597102105579 no 1921 0.448055086794667 2699 5412760 SGTC_3355 9151058 44.0485 µM -0.130808520015681 0.439511292753823 no 1922 0.447963391457776 2622 17015728 SGTC_3037 9091026 49.47 µM -0.132662369386511 0.438825176095925 no 1923 0.447230202313646 2698 25236398 YIL048W NEO1 SGTC_2379 9035213 200 µM -0.133144554097595 0.438646747746748 no 1924 0.44703952986051 2633 646551 SGTC_2415 st077333 57.7 µM -0.133163677188048 0.43863967166667 no 1925 0.447031968183543 2652 2766255 SGTC_2236 dapsone 200 µM -0.133659613536807 0.438456168157685 no 1926 0.446835871129072 2651 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2726 cimetidine 79.27 µM -0.133797339201086 0.438405210046866 no 1927 0.446781415644019 2643 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_186 3455-3465 67.277 µM -0.135012521016432 0.437955640519042 no 1928 0.44630098731861 2641 755278 SGTC_685 1278-0033 54.9 µM -0.135793890337577 0.437666606828061 no 1929 0.445992110562986 2708 3590572 SGTC_1934 st074720 32.6 µM -0.135995940703577 0.43759187246396 no 1930 0.445912245000351 2650 17250992 SGTC_1672 st016598 6.51 µM -0.136196191164245 0.437517806045281 no 1931 0.445833093061496 2713 4665860 YNL267W PIK1 SGTC_1188 1403-0014 4.57 µM -0.138154906953685 0.436793453816234 no 1932 0.445058996151606 2663 9614867 SGTC_646 4092-0839 27.3 µM -0.139154011375156 0.436424056685753 no 1933 0.444664224225584 2758 877796 SGTC_648 0375-0473 33.3 µM -0.140936066581147 0.435765318362841 no 1934 0.443960224745288 2674 1713139 SGTC_3069 9117009 49.47 µM -0.141783180131823 0.435452244436725 no 1935 0.443625635075824 2672 41904981 SGTC_1675 st018485 24.5 µM -0.141813302861979 0.435441112503557 no 1936 0.443613738053576 2742 3323024 SGTC_1368 1852-0141 284 µM -0.142405966727909 0.435222102448708 no 1937 0.443379674826498 2780 2838987 SGTC_264 promethazine 12.5 mM -0.142513624648334 0.435182321207269 no 1938 0.443337159150011 2650 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_440 fluspirilene 35.1 µM -0.142622070316748 0.435142249544208 no 1939 0.44329433303988 2919 3396 An atypical antipsychotic. SGTC_2851 9015922 71.43 µM -0.143767657562436 0.434718985375162 no 1940 0.442841971516083 2803 2996893 SGTC_1066 ketoconazole 628 nM -0.144543443607479 0.434432395415252 no 1941 0.442535676789288 2812 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1425 4048-4433 7.33 µM -0.145486896679516 0.43408391254254 no 1942 0.442163230306882 2700 23734946 SGTC_863 0466-0191 129 µM -0.146680349933502 0.433643160616866 no 1943 0.441692164654306 2666 765160 YPR165W RHO1 SGTC_1198 1612-1005 86.7 µM -0.148081229517045 0.43312590976638 no 1944 0.441139331397942 2845 6998509 SGTC_224 benfluorex 43.875 µM -0.148419677202806 0.433000960887114 no 1945 0.441005785944269 2662 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1579 chlormadinone acetate 49.4 µM -0.148517821410201 0.432964729039662 no 1946 0.440967061234843 2814 45114258 A steroidal progestin. SGTC_1555 citronellol 128 µM -0.149987502801133 0.432422235070845 no 1947 0.440387237521025 2682 8842 A terpine precursor. SGTC_2204 7233102 200 µM -0.150648239626566 0.432178383010245 no 1948 0.440126602945555 2685 2172480 SGTC_2185 6113692 200 µM -0.150865445788249 0.432098226368499 no 1949 0.440040929355697 2782 874150 SGTC_2584 androsterone 48.74 µM -0.15146027926563 0.431878726407556 no 1950 0.439806320931742 2729 2754130 A steroid. SGTC_162 k030-0015 37.8 µM -0.152241764657157 0.431590381851857 no 1951 0.439498127216049 2769 1809920 YMR134W ERG29 SGTC_642 0335-0876 158 µM -0.152638759751949 0.431443916578071 no 1952 0.439341578637397 2672 6812350 SGTC_3124 9127567 49.47 µM -0.152717264875422 0.431414954427981 no 1953 0.439310622537495 2836 17592030 SGTC_2850 9015429 58.44 µM -0.154023991813061 0.430932930326518 no 1954 0.438795409288179 2739 6457570 SGTC_74 000s-0487 160.283 µM -0.155679786048372 0.430322290475072 no 1955 0.438142715639513 2658 677548 SGTC_1810 st050138 53 µM -0.156720432762265 0.429938595850248 no 1956 0.437732591528024 2682 3444541 SGTC_1419 3993-2473 62.6 µM -0.158783461208623 0.429178136963244 no 1957 0.436919739766893 2708 704026 SGTC_3206 9114350 49.47 µM -0.159382778160338 0.428957270139117 no 1958 0.436683653252173 2783 17087243 SGTC_2141 5621638 7.665 µM -0.160146489488467 0.428675851145778 no 1959 0.436382840210126 2818 2856238 SGTC_2966 9084041 48.03 µM -0.161074691206006 0.428333868130923 no 1960 0.436017286715663 2652 17741380 SGTC_944 3370-0224 231 µM -0.162352302851981 0.427863237947609 no 1961 0.435514214622916 2727 4580514 SGTC_1718 roemerine 11.9335 µM -0.162989005223984 0.427628735965356 no 1962 0.435263545736158 2791 235224 An aporphine alkaloid with mutagenic activity. SGTC_633 0437-0093 97.7 µM -0.163068212336649 0.427599565212354 no 1963 0.435232363817269 2672 2831118 SGTC_497 capsazepine 133 µM -0.163735444868142 0.42735384952844 no 1964 0.434969706559982 2707 2733484 A calcium channel blocker. SGTC_426 0988-0037 14.6 µM -0.164622522752296 0.427027217036736 no 1965 0.434620551245546 2674 5383008 SGTC_2165 5727197 32.143 µM -0.165547624574943 0.426686636974827 no 1966 0.434256483959865 3108 1361712 SGTC_2569 tetrandrine 100 µM -0.166332550689715 0.426397706028322 no 1967 0.433947625541923 2762 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_471 1-acyl-paf 4 µM -0.167297692723675 0.426042491840053 no 1968 0.433567909747832 2682 16759367 SGTC_2786 7743617 45.45 µM -0.167863212319517 0.425834383924955 no 1969 0.433345445857675 2746 583674 SGTC_539 4859-0462 2.54 µM -0.16967478482926 0.425167875142651 no 1970 0.4326329526468 2883 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_639 0833-0042 114 µM -0.169745546952184 0.425141844863747 no 1971 0.432605126264702 2719 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_670 4204-0025 119 µM -0.169814718418745 0.425116400032923 no 1972 0.432577925712775 2822 719039 SGTC_2497 7-hydroxyflavone 100 µM -0.171233834434003 0.424594445012093 no 1973 0.432019952166483 2884 5281894 SGTC_1270 0831-1170 17.3 µM -0.171939689065074 0.424334878785849 no 1974 0.431742471919243 2697 6764716 SGTC_1741 st038134 10.228 µM -0.173079440385655 0.423915823631289 no 1975 0.431294492623239 2895 1272587 SGTC_2041 5107442 45.335 µM -0.174307866878451 0.423464261387957 no 1976 0.430811758506854 2831 793005 SGTC_174 3553-0389 74.3 µM -0.174547588702635 0.42337615277842 no 1977 0.430717567177378 2846 738071 SGTC_135 0933-0004 26.348 µM -0.175654738626097 0.422969274899845 no 1978 0.430282597829358 2815 21230617 YGL099W LSG1 SGTC_2184 6075246 200 µM -0.177073844477778 0.422447873328011 no 1979 0.429725193169961 2779 2267320 SGTC_1157 4092-0394 27.6 µM -0.17753588967949 0.422278140005677 no 1980 0.429543738535293 2902 3659885 SGTC_2448 5185112 27.17 µM -0.177727777656321 0.422207653774629 no 1981 0.429468384560188 2855 5718189 SGTC_729 4092-0585 94.1 µM -0.178161365980927 0.42204839290761 no 1982 0.429298124872351 2720 2169061 SGTC_614 0462-0418 107 µM -0.178453057208161 0.421941259282865 no 1983 0.429183592153731 2735 5188303 SGTC_3191 9110352 49.47 µM -0.180125289402093 0.42132718627179 no 1984 0.428527104618957 2679 17122424 SGTC_1481 3346-2004 36 µM -0.180393725302217 0.421228629678862 no 1985 0.428421740002648 2736 2770522 SGTC_1978 st071761 42 µM -0.180933148286216 0.421030594752517 no 1986 0.428210024832036 2749 5147680 SGTC_3039 9090270 49.47 µM -0.181205658019146 0.420930557581812 no 1987 0.428103076832567 2755 17173750 SGTC_3330 9141424 71.43 µM -0.182054542585621 0.420618968395652 no 1988 0.427769961123581 2854 27261020 SGTC_2700 st077718 96.8 µM -0.186296562336938 0.419062653468282 no 1989 0.426106101567156 2794 904970 SGTC_1546 5-methoxyflavanone 78.7 µM -0.186852136348789 0.418858917332298 no 1990 0.425888283906164 2818 147795 SGTC_554 4483-2211 187 µM -0.190710028238995 0.417444781809411 no 1991 0.424376390748872 2856 747107 SGTC_230 MPP+ 141.667 µM -0.190756932584828 0.417427595243455 no 1992 0.424358015911964 2770 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_445 e6 berbamine 66 µM -0.191871254911067 0.417019334675381 no 1993 0.423921527164614 2842 6610268 A calcium/calmodulin antagonist. SGTC_708 3448-5400 146 µM -0.192883338076582 0.416648609561274 no 1994 0.423525167144703 2787 3462195 SGTC_2172 5754775 163.918 µM -0.193565594361937 0.41639874152707 no 1995 0.423258020170218 2768 2263357 SGTC_1816 st051957 91.6 µM -0.195686575317851 0.415622174323843 no 1996 0.422427746303966 2782 674121 SGTC_3215 9129942 49.47 µM -0.199340742632333 0.414285026887199 no 1997 0.420998105315552 2852 17682944 SGTC_3288 9119690 36.221 µM -0.199705755548785 0.414151514197277 no 1998 0.420855356087833 2816 17595618 YKL019W RAM2 SGTC_1122 capsaicin 818.572 nM -0.201840895286701 0.413370732151618 no 1999 0.420020554819158 2902 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1142 3253-1408 9.78 µM -0.20335181759871 0.412818421869331 no 2000 0.419430028456217 2747 256655 SGTC_381 3461-2219 42.7 µM -0.203752718285705 0.412671903498121 no 2001 0.419273371498709 2884 2883159 SGTC_2252 omeprazole 400 µM -0.204089461240535 0.412548842445869 no 2002 0.419141794864589 2831 4594 A proton pump inhibitor. SGTC_249 wiskostatin 11.211 µM -0.204125614856881 0.412535630795827 no 2003 0.419127668985605 2773 2775510 A n-wasp and actin depolymerizer. SGTC_901 1112-0062 60.1 µM -0.204168417162912 0.412519989636965 no 2004 0.419110945476757 2772 1908457 SGTC_3319 9138450 16.7555 µM -0.204382780326644 0.412441657436464 no 2005 0.419027192743312 2791 2029690 SGTC_2931 9014674 55.67 µM -0.204695423147495 0.412327418314066 no 2006 0.418905048247924 2797 2996810 SGTC_1757 st041620 31.8375 µM -0.205336911953702 0.412093042727506 no 2007 0.418654453428292 2849 5289815 SGTC_2890 9046729 58.44 µM -0.206842265593636 0.411543167068642 no 2008 0.418066523340001 2811 903329 SGTC_1191 1487-1166 10.6 µM -0.207656466424232 0.411245828054489 no 2009 0.417748605702803 2893 3955771 SGTC_2174 5790901 200 µM -0.207702641750491 0.411228966755534 no 2010 0.417730577422375 2863 786020 SGTC_322 k048-0136 19.3 µM -0.209051001573106 0.410736674543201 no 2011 0.417204212294697 2861 6823282 SGTC_2109 5483026 200 µM -0.209400386947778 0.410609135279317 no 2012 0.417067845359591 2811 759335 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.209701002350785 0.410499406517915 no 2013 0.416950521583098 2820 5357218 A potent inhibitor of glutathione S-transferases. SGTC_809 3998-0021 90 µM -0.209780587751068 0.410470357923421 no 2014 0.416919462337513 2923 715485 SGTC_1337 1486-1011 40.3 µM -0.210021360140614 0.410382479224211 no 2015 0.416825500914875 2776 X1337 SGTC_806 3966-4455 5.86 µM -0.212660979078559 0.409419349636512 no 2016 0.415795702355685 2777 714982 SGTC_2294 7971431 200 µM -0.212991879064507 0.40929865110264 no 2017 0.415666648462926 2921 5741572 SGTC_1553 gossypol 38.6 µM -0.213512332584384 0.409108828734272 no 2018 0.415463685439714 2743 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2312 7706453 155.7 µM -0.213655111856617 0.409056757299164 no 2019 0.415408009262923 2836 976098 SGTC_552 k242-0005 476 µM -0.214429475986634 0.408774375575998 no 2020 0.415106078839039 2898 4088318 SGTC_1796 st049173 110.4 µM -0.21483304138405 0.408627229082527 no 2021 0.41494874550181 2773 94134 SGTC_3098 9119039 49.47 µM -0.215589273003495 0.408351529457031 no 2022 0.414653959042592 2770 17161528 SGTC_1906 st060206 94.7 µM -0.218104850779864 0.407434751509437 no 2023 0.413673709004825 2939 5133468 SGTC_2203 7227154 166.4 µM -0.218430259907355 0.407316196217618 no 2024 0.413546945352897 2789 896304 SGTC_813 k007-0158 173 µM -0.219349851537002 0.406981210199127 no 2025 0.413188765695911 2870 6523916 SGTC_2214 7179297 48.276 µM -0.220164165085769 0.406684631347205 no 2026 0.412871652004986 2785 769744 SGTC_1804 st050076 49.1 µM -0.22087250814882 0.4064266912227 no 2027 0.412595852048611 2906 3895976 SGTC_928 2764-0428 58.7 µM -0.221274033237084 0.406280495585923 no 2028 0.41243953367521 2917 662578 SGTC_3118 9124250 49.47 µM -0.221733829983444 0.406113099234987 no 2029 0.412260546528235 2865 1504786 SGTC_2849 9019321 12.99 µM -0.222795147352375 0.405726775264972 no 2030 0.411847472473131 2926 16489627 SGTC_1250 0485-0349 40.2 µM -0.223376006024823 0.405515379119438 no 2031 0.411621438492524 2829 6842794 YDL195W SEC31 SGTC_1446 4239-0190 62 µM -0.223917248402227 0.405318425621618 no 2032 0.411410847096523 2816 1340085 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.224695341538197 0.40503532616427 no 2033 0.411108144433089 2959 5282362 SGTC_1569 carminic acid 40.6 µM -0.225253227154145 0.40483237703569 no 2034 0.410891141972585 2928 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2046 4110841 106 µM -0.225408614607053 0.404775854325686 no 2035 0.410830705296056 2947 44119630 YMR134W ERG29 SGTC_374 0880-0231 82.3 µM -0.225740521045294 0.404655128895243 no 2036 0.410701620098016 2877 6833587 SGTC_808 0711-0032 135 µM -0.227203413456405 0.404123134488812 no 2037 0.410132786773243 2777 4252555 SGTC_2437 5741531 144.16 µM -0.227874272321777 0.403879229658895 no 2038 0.40987199213614 2989 2262990 SGTC_602 3130-1533 38.1 µM -0.228346746518464 0.403707474162512 no 2039 0.409688342940761 2929 720941 SGTC_578 3460-0051 92 µM -0.228621721148396 0.403607522954509 no 2040 0.409581470307737 2817 2876744 SGTC_2373 9071805 200 µM -0.229853133687968 0.403159991073585 no 2041 0.409102947581996 2940 10149009 SGTC_730 1436-0052 41.2 µM -0.230664288755305 0.40286526247882 no 2042 0.408787809422348 2812 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_107 0358-0022 2.6945 µM -0.23149067589494 0.402565056145988 no 2043 0.408466814150296 2881 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1872 amphotericin b 148 nM -0.231538387283102 0.402547725512429 no 2044 0.408448283389583 2948 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2994 9053520 71.4286 µM -0.231724394017585 0.402480162454372 no 2045 0.408376041664059 2960 4647384 SGTC_95 0471-0001 561.058 µM -0.231943219319023 0.402400682467061 no 2046 0.40829105777406 2839 4015405 SGTC_1992 st073643 23.3 µM -0.232232932823879 0.40229546123687 no 2047 0.408178550087269 2773 3161292 SGTC_733 4069-0007 56.1 µM -0.232928299734796 0.402042939391199 no 2048 0.407908541378862 2829 5717425 YNL287W SEC21 SGTC_2907 7721985 69.9 µM -0.233258294298539 0.401923116471031 no 2049 0.40778042085664 2872 3267881 SGTC_2740 felodipine 17.08 µM -0.233629037145664 0.401788508611437 no 2050 0.407636491560972 2920 3333 L-type calcium channel blocker SGTC_67 0335-0847 266 µM -0.233939721524528 0.401675715516676 no 2051 0.40751588768379 3184 4552207 YOR254C SEC63 SGTC_2969 9091408 28.7 µM -0.234840825504599 0.401348618597101 no 2052 0.407166139755265 2811 4286311 SGTC_3228 9131799 49.47 µM -0.234888860858228 0.401331183906192 no 2053 0.407147497738608 2877 17015818 SGTC_2930 9013230 14.89 µM -0.236493837568638 0.400748762089025 no 2054 0.406524744294761 2963 2995857 SGTC_1730 st033808 45.1 µM -0.236572002879136 0.400720402700076 no 2055 0.40649442108237 2806 1045166 SGTC_1049 3226-0134 66 µM -0.237317947062451 0.400449790815135 no 2056 0.406205070002392 2807 5702385 SGTC_1937 st074714 47.2 µM -0.239425167601141 0.399685596811194 no 2057 0.405387958249074 2789 17250970 SGTC_1200 1643-0193 18.4 µM -0.240165627410821 0.399417156428914 no 2058 0.405100929642119 2838 5403974 SGTC_589 1227-0070 34.1 µM -0.240661892566572 0.399237271028639 no 2059 0.404908588141488 2958 2841384 SGTC_1833 st055984 71 µM -0.241182307963469 0.399048654668242 no 2060 0.40470691121165 2875 676288 SGTC_2708 st078559 56 µM -0.241476998955098 0.398941859010458 no 2061 0.404592720634282 2895 17250902 SGTC_2427 5545055 42.75 µM -0.242754897854523 0.398478837625275 no 2062 0.404097638409283 2863 5372858 SGTC_895 0964-0006 13.7 µM -0.242905280314202 0.398424358899912 no 2063 0.404039387481492 2961 6738897 SGTC_2702 st077768 96.8 µM -0.243604021531711 0.398171253428511 no 2064 0.403768756692265 2917 6484119 SGTC_1663 st014140 55.4 µM -0.245003561022003 0.397664426293043 no 2065 0.403226837041395 2861 4207120 SGTC_1800 st050079 29.0735 µM -0.246499343084889 0.397122936935747 no 2066 0.402647856448242 2949 3645560 SGTC_1766 st045414 44.774 µM -0.247913667147972 0.39661111858243 no 2067 0.402100602548489 2840 253960 SGTC_1668 st014914 51.6 µM -0.248246352323575 0.39649075166103 no 2068 0.401971902274817 2878 2839556 SGTC_1148 3909-7663 27.7 µM -0.250394504020052 0.395713779132821 no 2069 0.401141139716591 2982 4084526 SGTC_292 k038-0015 474 µM -0.251851222014275 0.395187129185478 no 2070 0.400578031810253 2969 46368540 SGTC_2418 pentamidine 31.67 µM -0.252115754123062 0.395091512909984 no 2071 0.400475796587559 2852 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3194 9111903 49.47 µM -0.253289329701903 0.394667395189271 no 2072 0.400022320498157 3054 17087251 SGTC_27 0485-0001 32.618 µM -0.254945800969329 0.394068976619628 no 2073 0.399382480355804 2824 2054479 SGTC_1347 1493-0251 600 nM -0.255281728685079 0.393947649461456 no 2074 0.399252755469214 2984 3986378 SGTC_3277 9138724 49.47 µM -0.256007822544613 0.393685441008884 no 2075 0.398972398519919 2924 15943418 SGTC_1501 4491-0275 38.4 µM -0.256116145068805 0.3936463274932 no 2076 0.398930577850185 2884 5104718 SGTC_1565 sinapyl alcohol 95.1 µM -0.257215139502971 0.393249559070597 no 2077 0.398506348731407 2941 5280507 A phenol propionate derived from cinnamic acid. SGTC_2873 9040596 71.43 µM -0.261047869349073 0.391866703882913 no 2078 0.397027796140119 2978 6463863 SGTC_2915 7971052 15.16 µM -0.261625290547547 0.391658487255137 no 2079 0.3968051719664 2880 5741558 SGTC_1279 0874-0590 65.2 µM -0.262125573381595 0.391478111615432 no 2080 0.396612315600686 2929 3523074 SGTC_297 0986-0032 24 µM -0.263817673007266 0.390868202740892 no 2081 0.39596020789745 2846 2847425 SGTC_3183 9108214 49.47 µM -0.264000783910799 0.390802217392975 no 2082 0.395889657350948 2956 4974831 SGTC_493 zm226600 134 µM -0.264339488166727 0.390680171134971 no 2083 0.395759167447288 3057 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.26521893409161 0.390363328218322 no 2084 0.395420404870056 2853 3256 An antibiotic and ribosome inhibitor. SGTC_3104 9120930 49.47 µM -0.26594716669516 0.390101018864609 no 2085 0.395139949451848 2962 17014836 SGTC_3090 9117696 49.47 µM -0.266757765481423 0.389809100058865 no 2086 0.394827837220144 2948 7923821 SGTC_2414 st077232 92.9 µM -0.267393333057178 0.389580258238642 no 2087 0.394583166037753 2842 729801 SGTC_2045 5106652 78.05 µM -0.26950529716273 0.388820101929648 no 2088 0.393770433213443 3015 673349 SGTC_1708 st033234 31.827 µM -0.272756478177819 0.387650741368829 no 2089 0.392520208383352 3014 674664 SGTC_1682 st012968 530 nM -0.272967460764158 0.3875748917978 no 2090 0.392439114280922 2897 24207270 SGTC_375 3970-0961 9.27 µM -0.273944503331979 0.38722369481419 no 2091 0.392063635273506 2922 2898222 SGTC_1723 st034307 2.5525 µM -0.274035318789458 0.387191055971291 no 2092 0.392028739848273 2959 867466 SGTC_3287 9117173 37.0625 µM -0.274401981961974 0.38705928627825 no 2093 0.391887860030869 2946 2789709 SGTC_1548 st061468 90.8 µM -0.278046039927819 0.38575041153516 no 2094 0.390488508425837 3017 390799 SGTC_2395 5646831 180.19 µM -0.278064758128041 0.385743691664453 no 2095 0.390481324109319 3074 6808628 SGTC_2861 9024595 19.48 µM -0.278886954927605 0.385448555255265 no 2096 0.390165789989485 2941 16482810 SGTC_1310 1188-0297 994 nM -0.278996496508554 0.385409239126322 no 2097 0.390123756720012 2941 1588352 SGTC_462 ag-879 158 µM -0.27901245385729 0.385403511890949 no 2098 0.390117633677123 3015 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2228 7354201 200 µM -0.279816524908416 0.385114955970107 no 2099 0.389809136451297 2923 753451 SGTC_4 0960-0234 25.671 µM -0.281750890860747 0.384421033444588 no 2100 0.389067264647983 2980 6821112 SGTC_776 4476-4378 112 µM -0.283282348736076 0.383871910135227 no 2101 0.388480203504518 2992 2892008 SGTC_1384 3089-0840 101 µM -0.283910775136423 0.383646647400168 no 2102 0.388239379387005 3030 1069836 SGTC_3106 9121286 49.47 µM -0.284946836207008 0.38327535175906 no 2103 0.387842436296141 3109 15943471 SGTC_1438 4092-1045 4 µM -0.284954714734656 0.38327252872282 no 2104 0.387839418266945 2913 1351342 SGTC_2235 salicylic acid 500 µM -0.287985736280345 0.382186913456875 no 2105 0.386678828579896 2917 338 A COX inhibitor and kinase inhibitor. SGTC_1169 aniline yellow 25.8 µM -0.288685236062882 0.381936506074114 no 2106 0.38641113090767 2948 6051 A DNA damaging agent. SGTC_1549 4'-methoxyflavonol 74.6 µM -0.289355655605048 0.381696555200981 no 2107 0.386154612932875 2925 97141 SGTC_77 0828-0286 12.516 µM -0.289540671957865 0.381630343716648 no 2108 0.386083830166343 2891 745345 SGTC_1257 0669-0121 16 µM -0.292432859037897 0.3805957730644 no 2109 0.384977843895213 3004 4307855 SGTC_2216 7189485 200 µM -0.292804146586839 0.380463020624115 no 2110 0.384835929291502 3031 731273 SGTC_1908 st060353 56.5 µM -0.295471071888767 0.379509886265737 no 2111 0.383817023838303 3141 4227716 SGTC_584 0986-0246 15.4 µM -0.297017749358619 0.378957452947879 no 2112 0.383226479132121 2952 53315 YDR232W HEM1 SGTC_851 0394-0702 453 µM -0.297517151674138 0.378779132047279 no 2113 0.383035857686133 3065 762646 SGTC_988 1497-1057 103 µM -0.298213247755571 0.378530621026772 no 2114 0.382770205652378 2961 3533044 SGTC_961 1252-1571 372 µM -0.298669996707495 0.378367585837549 no 2115 0.382595925921238 3117 6813498 SGTC_907 3448-6986 75.5 µM -0.29923800113513 0.378164868541564 no 2116 0.382379228085389 3111 590582 SGTC_3313 9133968 57.047 µM -0.299370986593875 0.378117411690002 no 2117 0.38232849848037 2885 1494643 SGTC_2602 kawain 100 µM -0.299782220208726 0.377970671549651 no 2118 0.382171639082566 2941 5369129 SGTC_1207 2099-0101 141 µM -0.302239757915404 0.377094118094126 no 2119 0.381234649067786 3048 5837381 SGTC_2157 5649910 96.377 µM -0.302839234741632 0.376880392828946 no 2120 0.381006190767974 2941 2858091 SGTC_2430 5571206 200 µM -0.302886608882153 0.376863504624651 no 2121 0.380988138433445 3101 1731771 SGTC_1809 st050081 57.6 µM -0.303204389104429 0.376750226607515 no 2122 0.380867052172174 3113 5036894 SGTC_1693 xanthone 101.9 µM -0.303818615322711 0.376531305592679 no 2123 0.380633041872401 2958 7020 An insecticide. SGTC_2820 7989630 71.43 µM -0.303879112697666 0.376509745412288 no 2124 0.380609995707463 3006 2984098 SGTC_2337 9009472 200 µM -0.303972439271908 0.376476486249092 no 2125 0.380574444258252 3150 5742383 SGTC_1917 st066507 28.5 µM -0.303976080774347 0.376475188530942 no 2126 0.380573057099425 2949 3156428 SGTC_2945 9067681 61.76 µM -0.304105451930795 0.376429085582654 no 2127 0.380523776694928 2901 16456930 SGTC_41 0478-0632 82.643 µM -0.30417476996578 0.376404384002768 no 2128 0.380497372682606 2986 3750424 SGTC_2459 5811157 9.22 µM -0.304400741387645 0.376323862281789 no 2129 0.380411301514935 2928 2870684 YBR192W RIM2 SGTC_1165 k072-0275 30.3 µM -0.305337091142476 0.375990264681534 no 2130 0.380054714610277 3051 6153523 YGL055W OLE1 SGTC_2765 myclobutanil 7.74 µM -0.305867995087931 0.375801158252268 no 2131 0.379852577524404 3047 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2661 dactinomycin 12.96 µM -0.306539824878489 0.375561897208525 no 2132 0.379596831194836 2976 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_743 1275-0778 158 µM -0.306846853204974 0.375452570084123 no 2133 0.379479971845041 3048 2849257 YMR203W TOM40 SGTC_2919 7978188 46.38 µM -0.307702953608291 0.375147781368754 no 2134 0.379154186025927 3115 2980291 SGTC_175 3793-3120 23.7 µM -0.310055381734995 0.374310672160868 no 2135 0.378259420763535 2954 5322297 SGTC_1413 3910-0535 34.4 µM -0.310156976946968 0.374274532917975 no 2136 0.378220792858141 3060 2876951 SGTC_2529 gangaleoidin 93.61 µM -0.310308697896682 0.374220565106076 no 2137 0.378163108719874 2924 4565183 SGTC_811 0416-0114 265 µM -0.310399538838622 0.374188253761398 no 2138 0.378128572393326 3046 6612453 SGTC_2528 xanthyletin 44.79 µM -0.310824979206996 0.374036940032965 no 2139 0.377966839484185 2940 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1787 fluconazole 80 µM -0.310905392116817 0.37400834225369 no 2140 0.377936272587431 3031 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_383 2324-0395 7.37 µM -0.311483990416604 0.373802591936734 no 2141 0.377716355886988 3085 3146421 SGTC_2103 5378138 10 µM -0.312363160636735 0.373490026691834 no 2142 0.377382272103528 2968 244142 SGTC_1973 st070275 50.2 µM -0.312689543832102 0.37337401112329 no 2143 0.377258270159968 2981 17118334 SGTC_1225 1216-0074 20.6 µM -0.314016467779441 0.372902463468242 no 2144 0.376754265724546 2980 4241466 SGTC_2521 angolensin 13.4 µM -0.31803226133852 0.371476537347189 no 2145 0.375230232681343 3122 821428 A flavenoid. SGTC_196 k015-0023 18.111 µM -0.318592562607834 0.371277725457685 no 2146 0.375017746984055 2960 5211998 SGTC_3256 9138902 49.47 µM -0.319722010012159 0.37087706768803 no 2147 0.37458953665336 2975 17228773 SGTC_2119 5528445 120.635 µM -0.321463253676771 0.370259656942953 no 2148 0.373929677490709 3111 791935 SGTC_2854 9024559 71.43 µM -0.322024959458886 0.370060558323426 no 2149 0.373716892970085 3059 3163529 SGTC_792 4534-1957 155 µM -0.324822796557858 0.369069374549011 no 2150 0.372657595074148 3000 1717904 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.326217345426051 0.368575655160316 no 2151 0.372129959425558 2979 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2207 7258803 200 µM -0.326508659304183 0.368472547149931 no 2152 0.372019769401826 3056 3666799 SGTC_2091 4-phenylthiadiazole 200 µM -0.326795819621816 0.36837091852446 no 2153 0.371911160727459 2977 270010 SGTC_3142 9086498 49.47 µM -0.327356273355407 0.368172595425221 no 2154 0.371699217428908 3078 25236367 SGTC_922 1866-0035 480 µM -0.327816503622419 0.368009763832715 no 2155 0.371525204085478 2967 3156169 SGTC_55 0767-0285 6.563 µM -0.33225741994169 0.366439769473634 no 2156 0.369847444589719 3091 3116166 SGTC_1689 st020265 53.493 µM -0.332726162664134 0.366274184963033 no 2157 0.369670499383596 3120 5758320 YPR016C TIF6 SGTC_2210 7115885 190.385 µM -0.332951482047507 0.366194599198853 no 2158 0.369585453620461 3013 2927039 SGTC_2274 7947094 46.08 µM -0.334818638793203 0.365535316678322 no 2159 0.36888094975589 2996 2971028 SGTC_2083 5306046 65.942 µM -0.334960664213062 0.365485184528719 no 2160 0.368827379607421 3007 539837 SGTC_3034 9090421 49.47 µM -0.336241186093007 0.365033289614579 no 2161 0.368344498529326 3016 17173761 SGTC_1103 duloxetine 36.1 µM -0.336305485437877 0.365010603374585 no 2162 0.368320256908348 3149 60835 A selective serotonin reuptake inhibitor. SGTC_2342 7990637 118.86 µM -0.336474702108868 0.364950902224964 no 2163 0.368256462707604 3112 2033102 YER133W GLC7 SGTC_2910 7948405 25.97 µM -0.336555385158836 0.364922437678417 no 2164 0.368226046707326 3165 2971328 SGTC_1887 st057648 70.8 µM -0.337547706665488 0.364572412907133 no 2165 0.367852027664656 3119 688672 SGTC_3272 9137413 49.47 µM -0.338031565777449 0.364401780639377 no 2166 0.36766970020262 2961 17614870 SGTC_2258 7960471 200 µM -0.338098830103123 0.364378062091425 no 2167 0.367644356065028 3073 2974708 SGTC_1638 st008370 60.6 µM -0.338598723151975 0.364201807556524 no 2168 0.367456022309636 2998 24207134 SGTC_2614 arthonioic acid 13.39 µM -0.340379198257459 0.36357427317167 no 2169 0.366785490935634 2971 6710684 SGTC_2245 6637752 200 µM -0.34058504323893 0.363501745984597 no 2170 0.366707995363859 3121 681890 SGTC_587 k089-0003 57 µM -0.341425710059059 0.363205597204089 no 2171 0.366391561418067 3032 9659696 SGTC_1175 0741-0056 27.6 µM -0.341961188960042 0.363017002155707 no 2172 0.36619005006188 3198 765927 SGTC_2017 5132927 60.65 µM -0.345501340914216 0.361771002326808 no 2173 0.364858751183197 3010 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_536 3852-0578 10.6 µM -0.346853908139894 0.361295335524775 no 2174 0.364350537680553 3166 2869208 SGTC_1356 1502-0781 85.8 µM -0.348741474424058 0.360631880268753 no 2175 0.363641702297847 3016 567702 SGTC_1739 st037196 92.5 µM -0.349184400210634 0.360476258219179 no 2176 0.363475438424434 3212 612214 SGTC_2688 kanamycin b 96.69 µM -0.352383044182534 0.35935310157287 no 2177 0.362275508157423 3179 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1215 3852-0577 11.2 µM -0.353951729911175 0.358802723835017 no 2178 0.361687529172305 3191 2884876 SGTC_1734 st037168 69.4 µM -0.354266629995044 0.358692275547593 no 2179 0.361569536773916 3109 708907 SGTC_2652 actinonin 100 µM -0.354393277457665 0.358647858454468 no 2180 0.361522085947103 3008 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1507 4075-3230 155 µM -0.354437021759116 0.358632517140739 no 2181 0.361505696825967 3083 659771 SGTC_2755 lomerizine 42.69 µM -0.354668749809265 0.358551252927022 no 2182 0.361418882463265 3077 3949 A calcium channel blocker. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.356571431434564 0.357884248059899 no 2183 0.360706333904529 3097 4213774 SGTC_1408 3909-7976 48.8 µM -0.360677422177421 0.356446330173127 no 2184 0.359170302348233 3080 24152374 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.361236990098955 0.356250526865865 no 2185 0.358961146152604 3232 94937 An inhibitor of serotonin biosynthesis. SGTC_337 1315-0038 354 µM -0.362021128200153 0.355976206010083 no 2186 0.35866812089444 3056 1626437 SGTC_1325 1431-0015 227 µM -0.36243268087813 0.355832259300156 no 2187 0.358514360682758 3042 1103340 SGTC_2082 5219693 150 µM -0.362553336688242 0.355790062019435 no 2188 0.358469286807179 3016 2834649 SGTC_2523 spermine 47.74 µM -0.364389474039456 0.355148123083909 no 2189 0.357783597245002 3145 1103 A DNA binding polyamine. SGTC_1002 4049-0206 172 µM -0.365415834700638 0.354789472149284 no 2190 0.357400511461947 3040 4662749 SGTC_675 1309-0189 238 µM -0.367025543788091 0.3542272354764 no 2191 0.35679998222541 3093 4246530 SGTC_3089 9117425 49.47 µM -0.367596416489139 0.354027918177728 no 2192 0.356587093626004 3108 9401657 SGTC_2841 9004761 38.96 µM -0.367924875165342 0.353913256622966 no 2193 0.356464625775437 3072 2991039 SGTC_583 1488-1091 88.9 µM -0.368799868486344 0.353607870108231 no 2194 0.35613845135382 3153 4303273 SGTC_2126 5251174 33.877 µM -0.370611408905367 0.352975913410805 no 2195 0.355463491615842 3241 790722 SGTC_3095 9117207 49.47 µM -0.370650709016694 0.35296220803526 no 2196 0.355448853846531 3150 17015229 SGTC_272 doxorubicin 8.13 µM -0.370991704329059 0.352843298601011 no 2197 0.355321855253308 3075 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_845 0330-0138 4.51 µM -0.37348354997874 0.351974797030767 no 2198 0.354394293142521 3123 9039800 SGTC_2918 7977171 22.06 µM -0.374014714899075 0.351789765781363 no 2199 0.354196684246008 3062 2236483 SGTC_2806 7952793 58.44 µM -0.374505597825566 0.351618797966087 no 2200 0.354014096330419 3202 2972490 SGTC_2790 5423970 71.43 µM -0.375878412847781 0.351140824657483 no 2201 0.35350364487017 3242 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1630 st005209 31.3 µM -0.376441504994459 0.350944840772805 no 2202 0.353294347391334 3184 3367314 SGTC_2848 9016370 25.97 µM -0.376551630869365 0.350906516161515 no 2203 0.353253419545345 3199 7894410 SGTC_389 tpck 16.7 µM -0.377526603025867 0.350567284903907 no 2204 0.352891149071512 3139 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_3178 9107506 49.47 µM -0.378240127124404 0.350319097213174 no 2205 0.352626109340986 3212 8897194 SGTC_2291 7917025 104.35 µM -0.378606119791044 0.350191817436107 no 2206 0.352490188491325 3013 2964612 SGTC_2546 rhodinyl acetate 100 µM -0.379959620133663 0.34972126240132 no 2207 0.351987694834857 3207 6708682 SGTC_1811 st050069 61.5 µM -0.381586727451374 0.349155891235644 no 2208 0.35138396528467 3169 3877702 SGTC_3220 9131269 49.47 µM -0.381851357069906 0.349063971955557 no 2209 0.351285811259221 3138 17722206 SGTC_3294 9122953 26.2835 µM -0.381851826245765 0.349063808994861 no 2210 0.351285637245559 3060 16459826 SGTC_1666 st014829 29 µM -0.382519041600747 0.348832090641591 no 2211 0.35103820384359 3047 3858230 SGTC_850 0388-0143 75.9 µM -0.383137471485593 0.348617365412545 no 2212 0.350808918667698 3076 67273 SGTC_766 1391-0721 126 µM -0.383951692893771 0.348334733304112 no 2213 0.350507125909943 3218 1020919 YIL115C NUP159 SGTC_304 1310-0298 97 µM -0.384054499403402 0.348299053145712 no 2214 0.350469027179809 3134 1550234 SGTC_2485 5633444 17.78 µM -0.384656042920732 0.348090307603213 no 2215 0.350246133285596 3146 5724239 SGTC_3049 9092223 49.47 µM -0.384985527133703 0.347975990638332 no 2216 0.350124069177201 3162 8623917 SGTC_2872 9044037 25.97 µM -0.385774780080165 0.347702209739571 no 2217 0.349831737401922 3067 6465195 SGTC_321 4534-3890 65.3 µM -0.387343345971602 0.347158331823681 no 2218 0.349251019871156 3182 699746 SGTC_3179 9107801 49.47 µM -0.38868027913269 0.346695017578739 no 2219 0.348756336252328 3082 4818259 SGTC_414 piperonyl butoxide 100 µM -0.390707154353591 0.345993041174139 no 2220 0.348006854994327 3082 5794 A potent inhibitor of cytochrome P450. SGTC_2457 5731572 11.68 µM -0.392055346264759 0.34552640883767 no 2221 0.347508660072473 3221 2865357 SGTC_1578 josamycin 24.2 µM -0.393648998906046 0.344975120974215 no 2222 0.346920100068854 3098 5282165 A P450 substrate. SGTC_3045 9092950 49.47 µM -0.394082200424691 0.344825321573683 no 2223 0.346760175953186 3244 44120432 SGTC_751 0833-0568 350 µM -0.39438587880873 0.344720325269194 no 2224 0.34664808390207 3180 6954252 SGTC_2217 6934799 96.0675 µM -0.396112239884438 0.344123666203841 no 2225 0.34601111457624 3184 675606 SGTC_3070 9117005 49.47 µM -0.397089787979816 0.343785981229745 no 2226 0.345650625107202 3190 8779016 SGTC_1166 k206-0078 225 µM -0.39795957486954 0.343485626103398 no 2227 0.345329992246836 3093 5404595 SGTC_477 mead ethanolamide 10 µM -0.398832367297431 0.343184332414738 no 2228 0.345008362984173 3130 16061185 SGTC_2356 9061756 188.97 µM -0.39925379541715 0.343038888319602 no 2229 0.344853104246799 3163 20104043 SGTC_3267 9137951 49.47 µM -0.400091407388958 0.342749879095046 no 2230 0.344544596393161 3041 16643986 SGTC_3232 9132874 49.47 µM -0.400264837164618 0.342690050462316 no 2231 0.344480731936862 3132 3784940 SGTC_912 3474-0017 2.18 µM -0.401233428032086 0.342355985116417 no 2232 0.344124135825118 3256 3360550 SGTC_130 0136-0219 337.655 µM -0.402300938560929 0.341987945388151 no 2233 0.343731281998462 3075 234244 SGTC_2961 9083290 32.55 µM -0.402835279626701 0.341803779903416 no 2234 0.343534702828523 3186 17741490 SGTC_2951 9072950 58.06 µM -0.403166338297108 0.341689696418636 no 2235 0.343412930608746 3185 16488155 SGTC_1044 1222-0021 1.78 µM -0.403625371831874 0.341531536461392 no 2236 0.343244112708713 3175 4306703 SGTC_2322 7413319 38.22 µM -0.405798726244433 0.340783085521716 no 2237 0.342445247328574 3216 1840400 SGTC_938 3126-1755 342 µM -0.406084891965329 0.340684583538013 no 2238 0.342340113071262 3283 1777771 SGTC_527 4476-4215 268 µM -0.406340299602892 0.340596678063143 no 2239 0.342246289325649 3119 4418754 SGTC_357 1325-0123 420 µM -0.406592671056027 0.340509826077428 no 2240 0.34215359048321 3227 1098503 SGTC_1137 ixabepilone 100 µM -0.40660151464668 0.340506782766865 no 2241 0.342150342306439 3122 154225 A novel microtubule stabilizer. SGTC_3340 9146634 11.102 µM -0.406839030363624 0.34042505128951 no 2242 0.342063109143051 3206 4907387 SGTC_2229 7354935 190 µM -0.407134331369455 0.34032344578131 no 2243 0.341954664745199 3187 318112 SGTC_889 0919-1524 82.7 µM -0.410642301844301 0.339117331520328 no 2244 0.340667420267414 3193 3905452 SGTC_667 1498-1044 59 µM -0.411424760395698 0.338848529967036 no 2245 0.340380550564662 3156 6739982 SGTC_2549 cedrol 20.94 µM -0.411437545804095 0.338844138418276 no 2246 0.340375863866951 3252 6708665 A sedative which affects the nervous system. SGTC_1509 1326-1131 80 µM -0.411665164879911 0.338765959187823 no 2247 0.340292430549651 3218 768313 SGTC_2684 capsaicin 100 µM -0.414069985934678 0.33794041175018 no 2248 0.339411426498957 3245 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1803 st050068 52.4 µM -0.415279777961973 0.337525398251277 no 2249 0.33896855151233 3237 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2247 cerulenin 830 nM -0.416879634187184 0.336976878445896 no 2250 0.338383225333408 3338 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1523 st012844 44.7 µM -0.419007504878734 0.336247862881097 no 2251 0.337605323777928 3274 4274103 SGTC_676 falcarinol 140 µM -0.419725921169728 0.336001869884256 no 2252 0.337342843375302 3322 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2220 6782180 200 µM -0.420234486212385 0.335827774521096 no 2253 0.337157082005807 3191 833803 SGTC_2035 5154463 94.595 µM -0.4206802551273 0.335675204912368 no 2254 0.336994290553252 3284 2769623 SGTC_2625 euphol 100 µM -0.422260952982106 0.335134411087841 no 2255 0.336417277808106 3291 6708538 A triterpene alcohol. SGTC_2008 4012253 172 µM -0.422378424274396 0.335094235024209 no 2256 0.336374411828746 3116 603940 SGTC_232 clozapine 119 µM -0.422683962301242 0.334989747561896 no 2257 0.336262929130749 3184 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1322 1348-1070 12 µM -0.423608677130228 0.334673592731439 no 2258 0.335925613045026 3247 6758089 SGTC_415 dibenzyl ketone 100 µM -0.424836039734848 0.334254145313042 no 2259 0.335478101635755 3208 7593 SGTC_3331 9141060 1.957 µM -0.425140915787383 0.334149986911011 no 2260 0.335366976249534 3125 4906567 YPR165W RHO1 SGTC_1705 st027868 56.3335 µM -0.427671401114563 0.33328596091646 no 2261 0.334445187076489 3213 292948 SGTC_2053 5265679 138 µM -0.429783246731905 0.332565554480672 no 2262 0.333676660380403 3124 764595 SGTC_2716 st080858 38.6235 µM -0.429832162007066 0.332548875497919 no 2263 0.333658867758731 3283 5296050 SGTC_1006 4099-6547 255 µM -0.430274869330247 0.332397937572733 no 2264 0.333497852790885 3273 3146833 SGTC_2491 paeonol 100 µM -0.431351048830464 0.332031135161233 no 2265 0.333106568620999 3125 11092 Increases levels of cortical cytochrome oxidase. SGTC_1426 4048-4480 71.7 µM -0.432038312286248 0.331796974112424 no 2266 0.332856784005582 3271 14224343 SGTC_1994 st072947 40.9 µM -0.43421302227417 0.331056450747349 no 2267 0.332066878772119 3276 5286565 YDL195W SEC31 SGTC_972 1319-0219 195 µM -0.434808139716914 0.330853918747377 no 2268 0.331850848077748 3227 23903702 SGTC_2478 5763493 32.33 µM -0.43630301823855 0.330345396024208 no 2269 0.331308446152428 3139 1365576 YLR208W SEC13 SGTC_2049 5262831 67.185 µM -0.436574292532117 0.330253148394577 no 2270 0.331210054833613 3230 763417 SGTC_1266 0828-0227 32.9 µM -0.439765542473425 0.32916873017296 no 2271 0.330053463288252 3231 3913820 SGTC_2472 5377652 49.4 µM -0.440150851630808 0.329037895287123 no 2272 0.329913926836157 3217 1610903 SGTC_1308 1187-1617 41.4 µM -0.444601898386683 0.327528027495322 no 2273 0.328303737666424 3171 2882570 SGTC_2315 7733312 200 µM -0.444614121949825 0.327523884929979 no 2274 0.328299320100628 3152 726316 SGTC_1401 3807-4679 7.6 µM -0.44509332268102 0.327361500548328 no 2275 0.328126157054356 3249 3291456 SGTC_205 1486-1330 71.903 µM -0.446659057547343 0.326831155557722 no 2276 0.327560623769825 3201 4118834 SGTC_2866 9034245 58.44 µM -0.446820422978172 0.326776517789646 no 2277 0.327502362076397 3215 6462273 SGTC_516 3992-2719 87.3 µM -0.448892602996235 0.326075215364951 no 2278 0.326754566178801 3098 5350887 YDR037W KRS1 SGTC_2496 diffractaic acid 79.83 µM -0.451343277369049 0.325246609872008 no 2279 0.325871079064262 3399 94870 An apoptosis inducer which activates caspases. SGTC_2253 7938677 135.83 µM -0.452053702981917 0.325006566775547 no 2280 0.325615147538241 3336 2301972 SGTC_294 k038-0071 157 µM -0.454427749503134 0.324204936225336 no 2281 0.32476049168819 3256 24152826 SGTC_737 1950-0117 57.9 µM -0.454735668240615 0.324101022663815 no 2282 0.324649708491603 3316 5393513 SGTC_2011 4012611 177 µM -0.456722810596947 0.32343075012608 no 2283 0.323935146575301 3186 2049887 SGTC_870 0573-2213 57.6 µM -0.458197447772092 0.322933717979089 no 2284 0.32340529667163 3304 3916321 SGTC_2447 5741742 33.78 µM -0.458360049671965 0.322878931712909 no 2285 0.323346894291682 3302 1776504 SGTC_830 4076-0286 57.8 µM -0.458793425956994 0.32273293086344 no 2286 0.323191258047318 3234 6866659 SGTC_1758 st042942 75.2445 µM -0.459380594471473 0.32253516228577 no 2287 0.322980440538929 3289 669317 SGTC_1919 st067113 52.3 µM -0.459409076902867 0.32252557018328 no 2288 0.322970215626739 3314 1268243 SGTC_802 4112-3352 742 µM -0.459422843045397 0.322520934166006 no 2289 0.322965273765188 3338 704594 SGTC_42 0133-0086 60.653 µM -0.459758501776449 0.322407903075802 no 2290 0.322844786431544 3174 162923 Model of phenazepam hydroxylation. SGTC_504 lovastatin 124 µM -0.464432003785553 0.320835838293038 no 2291 0.321169132618488 3255 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2271 7849410 118.62 µM -0.46446700835533 0.320824075581281 no 2292 0.32115659562926 3353 972430 SGTC_555 4296-0685 37 µM -0.464812154689462 0.320708104446262 no 2293 0.321032991373449 3274 2908540 YHR072W ERG7 SGTC_948 3448-0295 75.3 µM -0.465644868944166 0.320428379757898 no 2294 0.320734860306496 3282 678569 SGTC_1863 st057641 20.1 µM -0.466176321600535 0.320249907920193 no 2295 0.320544648307468 3301 3921635 SGTC_1521 st012942 49.4 µM -0.469119786417519 0.319262190544771 no 2296 0.319492008375034 3371 24207259 SGTC_842 0271-0008 11.1 µM -0.469310819201123 0.319198131251489 no 2297 0.319423741475159 3357 1221709 SGTC_896 0964-0007 44.5 µM -0.469506722592461 0.319132444296454 no 2298 0.319353740385756 3321 6756758 SGTC_402 epigallocatechin gallate 10 µM -0.470446688097968 0.318817350248985 no 2299 0.319017957235774 3226 65064 An antioxidant. SGTC_2397 5161689 200 µM -0.47278934411671 0.318032618203668 no 2300 0.318181738580847 3399 2259942 SGTC_580 1123-0028 41 µM -0.472996907117667 0.317963129027813 no 2301 0.31810769288427 3301 1677248 YPR107C YTH1 SGTC_465 cgp-37157 41 µM -0.473722715971924 0.317720188824438 no 2302 0.317848826150414 3265 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2375 9072683 200 µM -0.474063280112463 0.317606223422266 no 2303 0.317727391330681 3393 16798029 SGTC_2626 ethyl orsellinate 100 µM -0.47637490299555 0.316833125818002 no 2304 0.316903655565157 3211 75653 A natural product. SGTC_873 0591-4978 488 µM -0.477032440231825 0.316613365348633 no 2305 0.316669510782536 3430 3305145 SGTC_62 0180-0423 3.232 µM -0.477438865717892 0.316477563185487 no 2306 0.316524821996397 3264 30102 YGL099W LSG1 SGTC_1101 ebselen 5.29 µM -0.479282656598416 0.315861793670662 no 2307 0.315868779320872 3391 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1296 1068-0102 11.9 µM -0.480307086774247 0.315519886019842 no 2308 0.315504525226832 3294 767053 SGTC_327 1273-0057 3.96 µM -0.48118703647438 0.315226325328528 no 2309 0.315191786744917 3272 3108138 SGTC_2382 9035899 200 µM -0.483086862193367 0.314592920940537 no 2310 0.31451703099966 3252 6462679 SGTC_3301 9125354 19.7965 µM -0.48353157436906 0.314444732005328 no 2311 0.314359173166642 3317 41905162 SGTC_1263 0774-1208 64.8 µM -0.48384783691507 0.31433936380433 no 2312 0.314246931272849 3402 906585 SGTC_1714 st033236 13.627 µM -0.484741786583671 0.31404161121889 no 2313 0.31392976055106 3424 2916566 SGTC_2108 5365811 200 µM -0.48563912312066 0.313742852246777 no 2314 0.313611526371749 3328 780283 SGTC_3354 9151612 71.43 µM -0.485692765119747 0.313724996560497 no 2315 0.313592506998804 3362 27261949 SGTC_1203 3992-3522 103 µM -0.486071724159895 0.313598865785892 no 2316 0.313458156934976 3532 5322312 SGTC_805 3852-0218 479 µM -0.487142434229363 0.313242613949445 no 2317 0.313078698323863 3242 6615355 SGTC_1669 st015249 58.4 µM -0.488548550339169 0.312775028848324 no 2318 0.312580672743217 3372 722793 SGTC_1825 st052143 62.6 µM -0.490594252801593 0.312095295657417 no 2319 0.311856726045671 3390 674173 SGTC_2105 5350118 200 µM -0.491368537081171 0.311838187966258 no 2320 0.311582906533351 3306 2133313 SGTC_2832 7992762 51.95 µM -0.492530511318214 0.311452516557967 no 2321 0.311172179014725 3143 2985177 SGTC_446 go6976 132 µM -0.492916802316833 0.311324348316626 no 2322 0.311035687270768 3348 3501 A protein kinase C inhibitor. SGTC_2837 9008476 45.46 µM -0.493667381939733 0.311075377438261 no 2323 0.310770552399807 3383 2992805 SGTC_650 1328-0195 38 µM -0.494810346751732 0.310696416541723 no 2324 0.310367000026909 3354 2780821 SGTC_2756 carbadox 75.1 µM -0.494995599258117 0.310635013200492 no 2325 0.310301613463611 3285 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2296 7971656 126.45 µM -0.495783400241574 0.310373949548803 no 2326 0.310023618897275 3328 666570 SGTC_898 1000-0849 28.3 µM -0.497752156459473 0.309721955490688 no 2327 0.309329370725214 3339 6751807 SGTC_3056 9094900 49.47 µM -0.4998752186106 0.309019530163233 no 2328 0.308581471296984 3288 25236784 SGTC_1247 0448-0043 5.84 µM -0.500187518452281 0.308916263066189 no 2329 0.308471523076034 3355 3089013 YGL099W LSG1 SGTC_2194 5927483 104.545 µM -0.502225570394107 0.30824271871841 no 2330 0.307754429001871 3296 760979 SGTC_116 0155-0182 31.788 µM -0.504804968619327 0.307391192876542 no 2331 0.306847912846972 3292 771486 SGTC_6 0844-0013 19.835 µM -0.505284176271589 0.30723310818245 no 2332 0.306679627595482 3423 1584900 SGTC_1152 3909-8331 15.9 µM -0.505489014928785 0.307165545360574 no 2333 0.306607706020344 3294 16001939 SGTC_1724 st037281 8.293 µM -0.507281521854789 0.306574594497545 no 2334 0.305978650963533 3295 574124 YDL195W SEC31 SGTC_1731 st035964 63 µM -0.509186782163919 0.30594702219439 no 2335 0.305310653550104 3275 6739575 SGTC_1327 1436-0082 2.18 µM -0.509335195407773 0.305898160340469 no 2336 0.305258646012614 3295 15992205 SGTC_594 1487-1584 10.8 µM -0.510088658169383 0.305650152305648 no 2337 0.304994675362958 3277 5013332 SGTC_1280 0880-0253 10.1 µM -0.511327814047253 0.305242468527006 no 2338 0.304560766008572 3312 6836607 SGTC_470 aa-861 153 µM -0.512260646972285 0.304935724657984 no 2339 0.304234301615998 3326 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_883 0850-0245 24.6 µM -0.513166890059737 0.304637855549613 no 2340 0.303917292251051 3434 6823229 YPR165W RHO1 SGTC_1940 st075990 51.1 µM -0.513178096127409 0.304634173085934 no 2341 0.303913373222317 3509 1084979 SGTC_1037 k284-1091 78.7 µM -0.513984668742914 0.304369174552562 no 2342 0.303631354782004 3392 3334711 SGTC_2992 9074591 71.4286 µM -0.513988869241007 0.304367794752253 no 2343 0.303629886381994 3413 17741321 SGTC_795 0685-0265 78 µM -0.51438205801097 0.304238650500268 no 2344 0.303492450438399 3439 302754 SGTC_993 3909-8757 62.7 µM -0.514785854644683 0.304106047467402 no 2345 0.303351335530649 3286 4288324 YLR208W SEC13 SGTC_317 4495-0002 170 µM -0.516543381081381 0.303529192512478 no 2346 0.302737474210893 3346 15991618 SGTC_1454 4239-0054 42.6 µM -0.51669266688393 0.303480216482892 no 2347 0.302685357951459 3480 1340767 SGTC_2514 salinomycin 42.74 µM -0.5167955205586 0.303446475444541 no 2348 0.302649453668848 3430 23682228 A polyether potassium ionophore. SGTC_1597 7-benzyloxygramine 47.5 µM -0.518041618564019 0.303037827541255 no 2349 0.302214616001189 3383 260807 SGTC_713 1488-1073 324 µM -0.519253964890738 0.302640484715721 no 2350 0.301791825608775 3383 3312542 SGTC_2676 harmalol 100 µM -0.519772862119167 0.302470489097688 no 2351 0.30161094807192 3401 5459187 A monoamine oxidase inhibitor SGTC_1376 2910-0861 41.3 µM -0.52039220384473 0.30226764298344 no 2352 0.301395121383839 3367 1112859 SGTC_3182 9108849 49.47 µM -0.523319107803458 0.301309853637692 no 2353 0.300376103056917 3423 17133045 SGTC_358 0075-0058 9.45 µM -0.52333924300395 0.301303269403616 no 2354 0.300369098266183 3510 1069125 SGTC_44 0929-0055 61.211 µM -0.524515608136315 0.300918709155365 no 2355 0.299959983377385 3275 1379590 SGTC_1953 st076800 12.1 µM -0.524774558410333 0.300834086615316 no 2356 0.299869959829063 3324 297591 SGTC_1916 st067606 49.2 µM -0.525845290419898 0.300484295374569 no 2357 0.299497851883471 3353 19590279 SGTC_663 1486-0733 13.9 µM -0.525846267960009 0.300483976111597 no 2358 0.299497512257848 3326 722445 YPR165W RHO1 SGTC_2864 9034755 47.6 µM -0.526283476122758 0.30034120001495 no 2359 0.299345631038624 3430 4930451 SGTC_1239 0337-0584 35.4 µM -0.528518660008905 0.299611750718909 no 2360 0.298569699608858 3478 914301 YML130C ERO1 SGTC_1387 3342-1166 1.8 µM -0.52977192215302 0.299203101834409 no 2361 0.298135037400756 3357 3418228 SGTC_1686 st019653 115.5 µM -0.530027423004416 0.299119822189106 no 2362 0.29804645879351 3424 97252 SGTC_2110 5483698 200 µM -0.5302786239674 0.299037954337356 no 2363 0.297959382591639 3347 2848765 YHR062C RPP1 SGTC_1783 st039459 87.517 µM -0.53042288539001 0.298990943302096 no 2364 0.297909381112231 3479 729761 SGTC_1141 3253-0389 52.6 µM -0.531348976513481 0.298689234321466 no 2365 0.297588486056474 3402 5402031 SGTC_3199 9111318 49.47 µM -0.531723981328804 0.298567101797082 no 2366 0.297458589967516 3366 8548020 SGTC_1033 k072-0102 21.3 µM -0.533304902155908 0.298052473378172 no 2367 0.29691126739808 3429 5965931 SGTC_757 1066-0008 322 µM -0.535383677582136 0.297376397007473 no 2368 0.296192287290879 3422 6842497 SGTC_702 1488-0190 94 µM -0.536408274277396 0.297043427211994 no 2369 0.29583820705828 3417 949357 SGTC_1646 st011709 75.6 µM -0.539354809778927 0.296086824165851 no 2370 0.294821028162473 3432 5757843 SGTC_3105 9121040 49.47 µM -0.541455470090837 0.295405701897353 no 2371 0.294096841277479 3354 41448907 SGTC_524 r073-0010 27.8 µM -0.542616856336444 0.295029441399055 no 2372 0.293696815321113 3348 2772106 SGTC_2572 astragaloside iv 100 µM -0.542834528189031 0.294958945660739 no 2373 0.293621868819869 3444 45006101 An anti-inflammatory agent. SGTC_222 nsc-310342 10.666 µM -0.544244518689445 0.294502490775551 no 2374 0.293136610169887 3414 432556 SGTC_3078 9116413 49.47 µM -0.544952020259624 0.294273574861032 no 2375 0.292893258484162 3346 17177322 SGTC_986 1493-0483 84 µM -0.545513148241107 0.294092077364234 no 2376 0.29270032004256 3427 40079 SGTC_1817 st052116 64.4 µM -0.546628103777941 0.293731597320582 no 2377 0.29231712861623 3450 4361398 SGTC_453 enantio-paf c16 10 µM -0.54815581303938 0.293238000782628 no 2378 0.291792459872924 3443 13871343 A lipid and platelet activating factor SGTC_736 0958-0254 92.6 µM -0.548640357514901 0.29308152682586 no 2379 0.291626142066621 3477 6812352 SGTC_2456 5770359 74.46 µM -0.549537067759845 0.292792054368271 no 2380 0.291318466762571 3460 3118787 SGTC_2302 7771753 200 µM -0.549877108572892 0.292682318461298 no 2381 0.291201833072325 3409 2203047 SGTC_818 4072-2707 53.5 µM -0.550317015320895 0.292540382775324 no 2382 0.291050977811358 3375 882871 SGTC_1125 tnp00248 1.32998 µM -0.550851536923497 0.2923679627139 no 2383 0.290867725843005 3475 24207736 SGTC_3066 9117245 49.47 µM -0.552547229619989 0.291821297907043 no 2384 0.290286742617001 3386 17176980 SGTC_1879 gemcitabine 100 µM -0.553156303296625 0.29162505838484 no 2385 0.290078192755129 3411 60750 A nucleoside analog which inhibits DNA replication. SGTC_269 exalamide 29 µM -0.553303060480553 0.291577783387236 no 2386 0.290027952864925 3356 3316 A derivative of salicylamide. SGTC_3172 9105863 49.47 µM -0.553341894812011 0.291565274253927 no 2387 0.290014659257547 3401 2348785 SGTC_2899 9053889 58.44 µM -0.554102056551526 0.291320464913983 no 2388 0.289754501381392 3441 6470052 SGTC_2264 7948757 110.76 µM -0.555079197947459 0.291005918473841 no 2389 0.289420245295473 3341 2971411 SGTC_1653 st012112 65 µM -0.555274026273095 0.29094322129125 no 2390 0.289353620972557 3475 720429 SGTC_1210 3013-0140 750 nM -0.557417909544569 0.290253721219527 no 2391 0.288620965920986 3471 905973 SGTC_2793 7325131 81.82 µM -0.557659415788942 0.290176097738255 no 2392 0.288538487877834 3378 4176441 SGTC_1885 st057546 99.9 µM -0.559063255937525 0.289725076610757 no 2393 0.288059275228414 3518 702008 SGTC_1545 lovastatin 49.4 µM -0.559445428362614 0.289602350508744 no 2394 0.287928882532583 3449 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1603 st002045 67.8 µM -0.559747002475941 0.289505523978074 no 2395 0.28782600870079 3477 5887985 SGTC_1156 4092-0367 4.88 µM -0.560232418826658 0.289349703079321 no 2396 0.287660458545867 3407 1357585 SGTC_3136 9095672 49.47 µM -0.560661940182131 0.289211857604032 no 2397 0.287514008790491 3366 17217380 SGTC_1143 3454-2408 5.08 µM -0.560969114318944 0.289113295727103 no 2398 0.287409296212534 3441 X1143 SGTC_3153 9100258 49.47 µM -0.562114348211195 0.288745967883009 no 2399 0.287019056561888 3368 25236848 SGTC_145 3737-0113 38.366 µM -0.563361883579928 0.28834607761632 no 2400 0.286594243376772 3502 6849351 SGTC_96 0929-0093 37.281 µM -0.563509897472065 0.288298649950544 no 2401 0.286543861193808 3374 6991579 SGTC_945 3381-0768 11.3 µM -0.564367768414615 0.288023837306779 no 2402 0.286251934823556 3482 1126236 YIL048W NEO1 SGTC_216 k038-0035 28.382 µM -0.565057837999467 0.287802868366987 no 2403 0.286017212405 3433 4444231 YPR107C YTH1 SGTC_2638 epoxomicin 18 µM -0.565556093135425 0.287643370620719 no 2404 0.285847791235129 3436 9915668 A protesome inhibitor. SGTC_3197 9113331 49.47 µM -0.566848172238915 0.28722995457265 no 2405 0.28540866940143 3530 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2065 5221596 34.26 µM -0.567132006392203 0.287139176153352 no 2406 0.285312249494461 3461 788581 SGTC_1370 2001-0092 44.6 µM -0.567484037613432 0.287026605201934 no 2407 0.285192684257822 3563 790957 SGTC_1657 st012939 43.4 µM -0.568475142817847 0.286709786376131 no 2408 0.284856189786107 3494 24207257 SGTC_522 1273-0010 11.6 µM -0.568596470752731 0.286671013820708 no 2409 0.28481501022392 3543 5705015 SGTC_1436 4092-1007 8.32 µM -0.570634688099729 0.286020036294332 no 2410 0.284123649823751 3431 2881121 SGTC_2458 5808907 16.39 µM -0.57139081442527 0.285778719112792 no 2411 0.28386737711932 3552 2731747 SGTC_1240 0356-0016 42.1 µM -0.57166626481562 0.285690833385736 no 2412 0.283774046655437 3398 4305613 SGTC_444 curcumin 90.4 µM -0.573504883847318 0.285104529707721 no 2413 0.28315144663258 3463 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1056 3448-1962 115 µM -0.574281919276715 0.284856919144599 no 2414 0.282888521170266 3452 715507 SGTC_3297 9117502 71.43 µM -0.576836134181264 0.284043715255466 no 2415 0.282025078618603 3476 7453720 SGTC_3170 9103054 49.47 µM -0.577885315023743 0.283710002043997 no 2416 0.281670775178387 3437 16432970 SGTC_834 0312-0008 75.7 µM -0.57937558808872 0.283236313544135 no 2417 0.281167886186968 3495 6385573 YIL048W NEO1 SGTC_176 1486-1328 72.834 µM -0.580017260560287 0.283032472610618 no 2418 0.280951489012949 3459 22310231 SGTC_2845 9003024 42.97 µM -0.580236856355687 0.282962729503096 no 2419 0.280877451172027 3562 2990173 SGTC_1410 3909-8106 77.9 µM -0.580655829804057 0.282829687415801 no 2420 0.280736218309953 3496 1039210 SGTC_1093 fluphenazine 7.97 µM -0.58507118230186 0.28142945296791 no 2421 0.279249927437653 3490 6602611 An atypical antipsychotic. SGTC_3102 9121669 49.47 µM -0.585601239445902 0.281261581856337 no 2422 0.279071757635741 3434 41905072 SGTC_553 k007-0256 45.7 µM -0.58628845729903 0.281044009349326 no 2423 0.278840843226046 3471 6287000 SGTC_404 fumagillin 50 µM -0.58727366140417 0.280732236606847 no 2424 0.278509963723809 3452 12015870 A methionine aminopeptidase binder. SGTC_785 1270-0111 65.3 µM -0.588203861498172 0.280438023768742 no 2425 0.278197732899686 3503 6741994 SGTC_1539 benzyladenosine 56 µM -0.588786826916884 0.280253713850899 no 2426 0.278002141861217 3440 92208 A nucleotide analog. SGTC_2667 digitoxin 100 µM -0.588973171459328 0.280194811675572 no 2427 0.277939635459558 3472 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_420 mitomycin C 81.9 mM -0.590180776265478 0.279813241894517 no 2428 0.277534729395 3475 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2477 5967686 25.23 µM -0.591041314543821 0.279541489454981 no 2429 0.277246369642358 3470 776118 SGTC_2471 5466956 24.79 µM -0.591356837564544 0.279441881435045 no 2430 0.277140677036594 3415 724419 SGTC_865 0488-0499 301 µM -0.592816473828214 0.278981310743956 no 2431 0.276651990793242 3532 9634651 SGTC_2419 paclitaxel 166.5 µM -0.59393270318723 0.278629347307257 no 2432 0.276278562360899 3445 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3303 9125618 40.5795 µM -0.594681529508865 0.278393352668569 no 2433 0.276028185292861 3476 22695467 SGTC_1314 1222-0010 41.1 µM -0.59484910225548 0.278340555006045 no 2434 0.275972171041851 3479 3526027 SGTC_1876 myriocin 605 nM -0.595930187717721 0.278000051432013 no 2435 0.275610932726556 3546 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1414 3917-0015 5.4 µM -0.595962621651769 0.277989839034507 no 2436 0.27560009871255 3506 6618702 SGTC_1911 st060208 74.3 µM -0.596505129290388 0.277819048058842 no 2437 0.275418914147619 3489 688783 SGTC_2917 7979103 53.79 µM -0.596797048944423 0.277727167806755 no 2438 0.275321444228317 3531 2980565 SGTC_1378 2093-0007 380 nM -0.597203589336649 0.277599235980001 no 2439 0.275185731540464 3503 3618014 SGTC_2403 6032726 181.2 µM -0.600752961600017 0.27648352935301 no 2440 0.274002269111705 3481 2881040 SGTC_2736 butenafine 14.65 µM -0.601338200177786 0.276299777338256 no 2441 0.273807375631907 3482 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1319 1306-0155 43.7 µM -0.601546616820412 0.27623435357701 no 2442 0.27373798622997 3541 3122360 SGTC_1130 3454-2858 15.9 µM -0.602252184602274 0.276012926280262 no 2443 0.273503141903917 3438 715628 YIL048W NEO1 SGTC_3129 9127257 49.47 µM -0.603729084817343 0.275549715227248 no 2444 0.273011886935364 3403 837894 SGTC_2377 9073351 62.6 µM -0.605128405250358 0.275111189092559 no 2445 0.272546840922136 3453 7337946 YHR072W ERG7 SGTC_433 pimozide 108 µM -0.606289868048361 0.274747465210856 no 2446 0.27216114273133 3409 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_3181 9108277 49.47 µM -0.606559052518974 0.274663201212805 no 2447 0.272071790781763 3467 17097298 SGTC_1080 nisoldipine 24.4 µM -0.607074840122386 0.274501777568701 no 2448 0.27190062319501 3475 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_7 0192-1582 4.227 µM -0.609835198735651 0.273638677460889 no 2449 0.270985491124578 3563 252616 SGTC_2251 lansoprazole 556 µM -0.610477716233923 0.273437969957742 no 2450 0.270772700211308 3402 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_3280 9140961 49.47 µM -0.610617871005572 0.273394198556246 no 2451 0.270726294409709 3463 4901226 SGTC_1654 st012436 41.8 µM -0.610807169650855 0.273335084657203 no 2452 0.270663623180605 3513 4323132 SGTC_2829 7992743 58.44 µM -0.611424118861109 0.273142468621908 no 2453 0.270459419690989 3488 16462845 SGTC_2372 9071633 200 µM -0.612061290338717 0.272943609678801 no 2454 0.270248603693573 3566 21321366 SGTC_341 1486-1430 230 µM -0.612251961532252 0.272884115838678 no 2455 0.270185533767833 3492 2054753 YPL210C SRP72 SGTC_469 w7 172 µM -0.613009664909216 0.272647758368817 no 2456 0.269934974577595 3544 45115570 A P450 inhibitor. SGTC_711 k292-0785 179 µM -0.613145254329141 0.272605473418849 no 2457 0.269890149810264 3564 4146315 SGTC_1749 st037932 54.2 µM -0.614645007016494 0.272137977424866 no 2458 0.269394592360005 3525 594497 SGTC_1452 4194-0072 190 µM -0.614927198990397 0.27205005841351 no 2459 0.269301399781723 3576 1343545 SGTC_1107 amlodipine 47 µM -0.616398464931211 0.271591903453161 no 2460 0.268815783123847 3477 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_570 0987-0065 62.6 µM -0.61721706634327 0.27133715590511 no 2461 0.268545780189026 3438 3104428 SGTC_1813 st051246 8.6015 µM -0.619334891500052 0.270678644888844 no 2462 0.267847881651871 3513 5291959 SGTC_1494 4358-1428 177 µM -0.620944620891346 0.27017865423214 no 2463 0.267318030508437 3582 1564571 SGTC_229 benomyl 22.8748 µM -0.623750247065118 0.269308317135042 no 2464 0.266395809288662 3558 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_760 0568-0725 82.9 µM -0.624284550058003 0.269142729793835 no 2465 0.266220364274686 3560 3916171 SGTC_1851 st056236 18.9 µM -0.6264540951618 0.268470885246859 no 2466 0.265508568706026 3592 5393171 SGTC_3203 9113543 49.47 µM -0.626948340026411 0.26831795010235 no 2467 0.265346549428654 3551 17018012 SGTC_2566 crystal violet carbinol 226 nM -0.62750808189099 0.268144801027937 no 2468 0.265163120081189 3526 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2446 5162541 200 µM -0.629463326181992 0.267540412531537 no 2469 0.264522885493804 3530 1549321 SGTC_2022 5136654 200 µM -0.63000062378006 0.267374448053626 no 2470 0.264347088056689 3552 1713771 SGTC_2533 agelasine 13.65 µM -0.631084773489897 0.267039726027184 no 2471 0.263992548235209 3624 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1144 3486-0183 12.5 µM -0.631668489609753 0.266859596300384 no 2472 0.263801761162937 3552 6744069 SGTC_3335 9143315 29.6265 µM -0.632708232886444 0.266538892689897 no 2473 0.263462096281052 3505 4899691 SGTC_862 0452-0056 10.2 µM -0.633410317220539 0.266322448590195 no 2474 0.263232864654397 3525 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_293 4049-0273 38.5 µM -0.634793795882036 0.265896199359697 no 2475 0.262781455075042 3514 1380311 SGTC_1882 5615643 20 µM -0.63678137759902 0.265284431873492 no 2476 0.262133628906365 3524 2253075 SGTC_438 sphingosine 6.67 µM -0.63710143779005 0.265185985821708 no 2477 0.262029386047221 3415 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.637853063909268 0.264954869069929 no 2478 0.261784666744984 3609 23847180 SGTC_2858 9025781 8.96 µM -0.639779086551775 0.264363105879563 no 2479 0.261158115394622 3620 4894980 YPL153C RAD53 SGTC_1636 st007707 68.9 µM -0.640189809028641 0.264237000040676 no 2480 0.261024603688061 3621 403051 SGTC_852 0418-0143 439 µM -0.640901297619499 0.264018621245037 no 2481 0.260793406370733 3619 5369229 SGTC_1167 k781-0610 148 µM -0.640902599430681 0.264018221761508 no 2482 0.260792983445417 3597 4525169 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.641505249556797 0.263833321113052 no 2483 0.260597235658765 3466 6708630 An antioxidant. SGTC_1430 4049-0248 69.1 µM -0.643062032267424 0.263355986331778 no 2484 0.260091924762793 3621 22774488 SGTC_1621 st003705 32.4 µM -0.643210622352413 0.263310449269501 no 2485 0.260043720825431 3617 24207032 SGTC_2355 9061122 103.12 µM -0.643984822082597 0.263073252336393 no 2486 0.259792638135262 3559 5302957 SGTC_1343 1487-0095 224 µM -0.644330666889342 0.262967328762511 no 2487 0.259680516758789 3582 4560101 YGL055W OLE1 SGTC_2788 5282734 71.43 µM -0.649155475717784 0.261491888136475 no 2488 0.258118943651349 3625 743706 SGTC_877 0771-0151 33.1 µM -0.649473667737159 0.261394733696268 no 2489 0.258016130652509 3574 6166523 SGTC_955 1216-0110 33 µM -0.649622451945155 0.261349311368453 no 2490 0.257968063352475 3561 3619719 SGTC_853 0419-0306 21 µM -0.650075276417122 0.261211093545097 no 2491 0.257821799198607 3519 762713 SGTC_1486 3970-0793 4.53 µM -0.650301147435197 0.261142163875441 no 2492 0.257748858028305 3620 2844330 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.651322154204581 0.260830697159349 no 2493 0.257419275104572 3583 688667 SGTC_747 3448-8087 38.7 µM -0.651335919289299 0.260826499310265 no 2494 0.257414833205505 3599 5168703 SGTC_3071 9117417 49.47 µM -0.652080639133597 0.260599438720635 no 2495 0.257174576558947 3522 45595590 YGL055W OLE1 SGTC_290 2043-6722 48.1 µM -0.65379949710069 0.260075758020367 no 2496 0.256620495270209 3599 773758 YLR208W SEC13 SGTC_2939 9044578 71.43 µM -0.65443527864069 0.259882193397198 no 2497 0.256415705960653 3584 2653634 SGTC_1688 st021091 57.6 µM -0.65528345774989 0.25962407977525 no 2498 0.256142634674978 3613 3656366 SGTC_3271 9137798 49.47 µM -0.656163378869581 0.259356446518583 no 2499 0.255859504403638 3548 6498326 SGTC_1398 3558-0053 112 µM -0.656863269245669 0.25914367250984 no 2500 0.255634418910386 3524 4532369 SGTC_2146 5545642 200 µM -0.656908050517371 0.259130061606333 no 2501 0.255620020726331 3630 825326 SGTC_1498 4478-3555 97.6 µM -0.657367683089376 0.258990381390114 no 2502 0.25547226302373 3584 3437919 SGTC_441 propafenone 146 µM -0.658499866841345 0.258646482152534 no 2503 0.255108491284452 3590 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1676 st018489 23.4 µM -0.65861668313651 0.258611012825275 no 2504 0.255070973519991 3599 3696235 SGTC_2057 5236571 38.335 µM -0.658688608370097 0.258589175175842 no 2505 0.255047874805417 3612 54684039 YBR257W POP4 SGTC_2080 5212524 12.4 µM -0.659306585181432 0.258401586901842 no 2506 0.254849457289632 3592 260183 SGTC_1466 k213-0079 57.5 µM -0.659498492920009 0.258343347218994 no 2507 0.254787856767913 3584 3657981 SGTC_405 ebelactone b 50 µM -0.659559017251293 0.258324980856544 no 2508 0.254768430661915 3600 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_25 0118-0223 35.662 µM -0.660225372387939 0.258122817335068 no 2509 0.254554606208212 3647 5333628 SGTC_2704 st078022 71.1 µM -0.663740033745098 0.257057873617723 no 2510 0.253428355896752 3643 54697681 SGTC_2827 7993847 71.43 µM -0.663962177516146 0.256990640836571 no 2511 0.253357259467787 3568 2985692 SGTC_1008 4106-0037 6 µM -0.664583629379897 0.256802604322284 no 2512 0.253158421418861 3603 2905394 SGTC_721 1187-1332 279 µM -0.666486585392543 0.256227260903295 no 2513 0.252550067603756 3565 25730 SGTC_790 1575-0012 79.1 µM -0.668655004647788 0.255572476949547 no 2514 0.251857788154652 3654 378741 YLR208W SEC13 SGTC_316 k060-0003 58.6 µM -0.669425531178465 0.255340016534936 no 2515 0.251612034876008 3640 6152314 SGTC_2706 st078239 82.5 µM -0.669474929821201 0.255325117212021 no 2516 0.251596283895623 3637 15434492 SGTC_2135 5326629 150.42 µM -0.670209809065166 0.255103521011233 no 2517 0.251362025854827 3600 5020077 SGTC_2747 doxorubicin 7.63 µM -0.67120644708928 0.254803154611605 no 2518 0.251044511069107 3526 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1496 4469-0713 57.4 µM -0.672292021952342 0.254476195240355 no 2519 0.250698903866986 3611 746691 SGTC_2653 dihydrofissinolide 100 µM -0.673032270443336 0.254253369280743 no 2520 0.250463380483537 3650 6857746 SGTC_1262 0737-0114 49.6 µM -0.673128809494771 0.254224317112811 no 2521 0.250432673492047 3661 765919 SGTC_1176 0848-0131 83.3 µM -0.673256462371741 0.25418590431779 no 2522 0.250392072926945 3687 6769040 SGTC_3017 9080681 49.47 µM -0.674415718548607 0.25383720494687 no 2523 0.25002352611055 3624 16451914 SGTC_1478 0453-0656 35.7 µM -0.674438704800073 0.253830293319092 no 2524 0.250016221310233 3647 5258496 SGTC_2361 9034121 116 µM -0.675213834744813 0.253597280991291 no 2525 0.249769959093011 3619 6496917 SGTC_1622 st003707 19.4 µM -0.678805572843963 0.252519034535904 no 2526 0.248630531139108 3671 10140899 SGTC_843 0310-0051 143 µM -0.680145060325571 0.252117537188043 no 2527 0.248206307648439 3655 2065037 SGTC_2813 7971799 71.43 µM -0.680215272479584 0.252096501121871 no 2528 0.248184081701944 3669 2234054 SGTC_1874 staurosporine 7.6 µM -0.681442666516395 0.251728914662747 no 2529 0.247795716584368 3667 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_3020 9089140 49.47 µM -0.681524250654172 0.251704491449428 no 2530 0.247769913695234 3650 17217859 SGTC_1972 st070201 17.4 µM -0.68197282823531 0.251570226602303 no 2531 0.247628066190184 3630 2829099 SGTC_2232 chlorophetanol 41.5365 µM -0.683279006133276 0.251179486912433 no 2532 0.247215278714461 3711 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_3162 9099653 49.47 µM -0.683706585090145 0.251051647559466 no 2533 0.247080232205806 3624 25237511 SGTC_3348 9149464 3.537 µM -0.685446078115341 0.250531921721846 no 2534 0.246531237933865 3652 1951442 SGTC_2960 9079389 5.97 µM -0.686420531189441 0.250241023891177 no 2535 0.246223980617495 3629 16457355 SGTC_2583 asiatic acid 100 µM -0.686498292102806 0.250217818095401 no 2536 0.246199470472561 3679 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_283 0987-0079 11.7 µM -0.687091584642026 0.250040802382181 no 2537 0.24601250846773 3674 411556 SGTC_1808 st050063 61.5 µM -0.687588198436134 0.24989268299464 no 2538 0.245856071049278 3646 4011993 SGTC_2799 7812892 81.82 µM -0.688959774222344 0.249483840637377 no 2539 0.245424290940081 3647 20205235 SGTC_600 1495-0418 41.6 µM -0.689905484774798 0.249202148306992 no 2540 0.245126813222217 3660 5377768 SGTC_2888 9058547 12.99 µM -0.689921822689053 0.249197283331041 no 2541 0.245121675758709 3590 16476514 SGTC_166 k072-0058 166.424 µM -0.691299340195486 0.248787278699075 no 2542 0.244688723187093 3672 5846229 SGTC_2612 dictamnine 15.46 µM -0.691702863523081 0.248667241973433 no 2543 0.244561974171555 3628 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2605 digitonin 300 nM -0.691919724612437 0.248602744705942 no 2544 0.244493871459305 3701 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1219 1469-0211 33.1 µM -0.692991063024351 0.248284245730036 no 2545 0.244157580006264 3636 6822282 SGTC_3248 9135562 49.47 µM -0.693003593412496 0.248280521849415 no 2546 0.244153648213232 3690 17650701 SGTC_1950 st077106 7.18 µM -0.69309274244772 0.248254028688205 no 2547 0.244125675958754 3656 13831864 SGTC_1386 3228-0095 33.8 µM -0.693203319043821 0.248221169814789 no 2548 0.244090982789071 3644 870181 SGTC_1364 1653-0028 37.6 µM -0.693765837946572 0.248054047958308 no 2549 0.243914534868005 3654 5718652 SGTC_2913 7966556 36.57 µM -0.69574772767791 0.247465716009414 no 2550 0.243293415074953 3596 2976516 SGTC_1624 st003710 6.25 µM -0.696292709260954 0.247304066842846 no 2551 0.243122769048609 3676 24207033 SGTC_60 0986-0278 202 µM -0.696918819822798 0.24711842338948 no 2552 0.242926799627039 3504 3110598 SGTC_3328 9140624 29.0385 µM -0.697638385258897 0.246905162409427 no 2553 0.242701684893349 3676 4904392 SGTC_2486 5283202 22.39 µM -0.698605122255473 0.246618801168861 no 2554 0.242399420854857 3671 1377751 SGTC_1029 k015-0030 64.7 µM -0.698661671312189 0.24660205604334 no 2555 0.242381746306178 3720 2208316 SGTC_1506 4226-2149 212 µM -0.700306018809468 0.246115403568231 no 2556 0.241868106881524 3700 991114 SGTC_1512 0259-0544 12.2 µM -0.701042904217228 0.245897486077645 no 2557 0.241638120177158 3662 18476 SGTC_533 1222-0222 6.71 µM -0.702613343777015 0.245433409181439 no 2558 0.241148372217672 3763 3982874 SGTC_1332 1480-0653 17.5 µM -0.707790791095309 0.243906773184192 no 2559 0.239537592970294 3650 5749438 SGTC_3353 9151644 39.2805 µM -0.708017570024615 0.24384002187417 no 2560 0.239467173276563 3710 4909158 SGTC_2975 9084847 53.72 µM -0.708151295402601 0.243800665060222 no 2561 0.239425653993829 3731 27211724 SGTC_3344 9148862 3.898 µM -0.709005936429042 0.243549216031669 no 2562 0.239160396467163 3701 4905352 SGTC_616 4092-0450 108 µM -0.710658890717541 0.243063288203732 no 2563 0.238647820039823 3730 787165 SGTC_152 4469-0003 551.229 µM -0.711028057386702 0.242954833973765 no 2564 0.238533424686343 3660 697280 SGTC_2420 aureobasidin a 50 nM -0.712150373768698 0.242625279345873 no 2565 0.238185831823069 3736 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_117 lucigenin 22.078 µM -0.713951451866655 0.242096920835972 no 2566 0.237628600025982 3682 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_104 0074-0074 590.992 µM -0.715703445497284 0.241583560794241 no 2567 0.237087241429382 3554 3943124 SGTC_2942 9052777 62.25 µM -0.719029057899203 0.240610735162386 no 2568 0.23606150798545 3793 6469503 SGTC_1404 3909-7820 48.3 µM -0.721759806308781 0.239813519533191 no 2569 0.235221082543827 3674 23741373 SGTC_3323 9138564 53.9225 µM -0.723191285229767 0.239396189476955 no 2570 0.234781186089488 3708 43912313 YNL103W MET4 SGTC_2298 7976326 193.81 µM -0.72348736130101 0.239309921673712 no 2571 0.234690258088492 3602 2235818 SGTC_2431 5490079 200 µM -0.723848620720032 0.239204684378398 no 2572 0.234579337991397 3751 5722345 SGTC_2024 5144227 134 µM -0.724564308675306 0.238996274363618 no 2573 0.234359680778021 3758 3475211 SGTC_1311 1190-0148 100 µM -0.725185146945369 0.238815565242333 no 2574 0.234169226836794 3774 1961333 SGTC_219 mitoxanthrone 164.414 µM -0.726079380350393 0.238555409647699 no 2575 0.23389505441625 3717 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1105 epirubicin 18.1 µM -0.726492054231056 0.238435404489714 no 2576 0.233768588398497 3712 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2719 novobiocin 32.65 µM -0.726611922338752 0.238400553158124 no 2577 0.233731861309358 3707 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1980 st071811 45.7 µM -0.72678526468376 0.238350159269213 no 2578 0.233678755594055 3774 4974850 SGTC_3224 9130643 49.47 µM -0.729569520820833 0.237541523447439 no 2579 0.232826679207931 3738 17644395 SGTC_2611 pyromycin 23.93 µM -0.729797550719404 0.237475363143708 no 2580 0.232756970922111 3719 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1420 4'-methoxyflavone 42 µM -0.732001754045947 0.236836360144875 no 2581 0.23208374858584 3710 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_990 3985-0011 41.3 µM -0.732372232441389 0.236729050594072 no 2582 0.231970701129434 3723 5399565 YGL099W LSG1 SGTC_197 4544-0043 41.561 µM -0.733864212963736 0.236297167309805 no 2583 0.231515750008976 3725 896523 SGTC_200 k038-0079 37.545 µM -0.734115007589502 0.236224612460256 no 2584 0.231439323816432 3681 3436683 SGTC_12 0849-0099 9.267 µM -0.734136819175083 0.236218302951629 no 2585 0.231432677702481 3660 6071388 SGTC_2935 9038016 29.96 µM -0.735408841559996 0.235850501464712 no 2586 0.23104526938467 3724 6463195 SGTC_81 0411-0046 9.971 µM -0.736113812726258 0.2356467971971 no 2587 0.230830718701616 3643 12925265 SGTC_1793 st048256 72.231 µM -0.736342949312319 0.235580608157314 no 2588 0.230761007318331 3635 672022 SGTC_1202 1988-0068 29.6 µM -0.737053816737497 0.235375330270263 no 2589 0.230544811372448 3704 2850480 SGTC_1373 2887-0003 58.5 µM -0.738233460928519 0.235034901218318 no 2590 0.230186296368793 3739 776948 SGTC_2468 5987765 72.9 µM -0.739280414998887 0.234732992681627 no 2591 0.229868369659779 3782 26772094 SGTC_3079 9117512 49.47 µM -0.741741087437472 0.234024257252879 no 2592 0.229122110299953 3774 7185044 SGTC_2037 5169046 200 µM -0.741786254625956 0.234011259056299 no 2593 0.229108424952936 3802 5718022 SGTC_2744 captopril 92.04 µM -0.74365443743576 0.233473984582692 no 2594 0.228542780263834 3695 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_188 3229-0966 278.469 µM -0.744590064326528 0.233205163115579 no 2595 0.228259788083927 3811 5722370 SGTC_1455 4262-0120 131 µM -0.744698387566344 0.233174051113167 no 2596 0.228227037078118 3841 1529587 SGTC_2346 9031566 143.75 µM -0.746120797652479 0.232765728188848 no 2597 0.22779722346596 3733 4771086 SGTC_3122 9126309 49.47 µM -0.747078727274643 0.232490965004316 no 2598 0.227508020091291 3791 17591206 SGTC_1448 4255-0083 152 µM -0.747552897893613 0.232355025295036 no 2599 0.227364942337778 3790 5399660 SGTC_2482 5981709 142.65 µM -0.747830161644996 0.232275557196454 no 2600 0.227281303383005 3759 877755 SGTC_1660 st012960 28.1 µM -0.747961701844751 0.232237861021352 no 2601 0.227241629234256 3740 24207266 SGTC_2955 9076254 12.21 µM -0.750524470217169 0.23150411447532 no 2602 0.226469445828185 3708 16459619 SGTC_2286 7945697 125 µM -0.754443301382782 0.230384616741636 no 2603 0.225291539425858 3775 1245733 SGTC_696 1560-0013 611 µM -0.754473196147832 0.230376088313048 no 2604 0.225282567133288 3790 1650269 SGTC_1929 genistein trimethyl ether 50.5 µM -0.755272497621329 0.23014812771505 no 2605 0.225042748453727 3737 136420 SGTC_2787 5284540 71.43 µM -0.755345095891518 0.230127428958117 no 2606 0.225020973576762 3809 736958 SGTC_2610 ononetin 44.17 µM -0.757859134894492 0.229411284984461 no 2607 0.224267658267894 3787 259632 SGTC_278 4092-0821 23.9 µM -0.758439243828867 0.229246213891324 no 2608 0.22409403596481 3773 877900 SGTC_2320 7373003 200 µM -0.761125026933186 0.228482837804453 no 2609 0.223291196707269 3819 5415828 SGTC_2369 9071472 200 µM -0.761941808530509 0.228250968704841 no 2610 0.223047367839324 3853 17296037 SGTC_858 0438-0351 2.77 µM -0.762086973378686 0.228209772952849 no 2611 0.223004048529887 3789 2799119 SGTC_637 1181-0519 7.26 µM -0.762767456686998 0.228016717047655 no 2612 0.222801046267685 3783 6252091 YGR060W ERG25 SGTC_169 k015-0017 16.025 µM -0.763033665356062 0.227941217560996 no 2613 0.222721659372707 3782 1840002 SGTC_1807 st050092 58.9 µM -0.763163340311939 0.227904445518791 no 2614 0.222682994450582 3780 5008496 SGTC_2055 5235184 200 µM -0.76332734116741 0.227857944430866 no 2615 0.222634100123197 3801 2836034 SGTC_285 1486-1325 46 µM -0.764995629649935 0.227385218500472 no 2616 0.222137073521218 3779 22310230 SGTC_2795 7780010 54.55 µM -0.765216706491397 0.227322615691674 no 2617 0.222071256526607 3793 953673 SGTC_1178 0988-0033 191 µM -0.765332951281422 0.227289702298327 no 2618 0.22203665364676 3812 5392207 SGTC_630 4356-0227 183 µM -0.766546935606996 0.226946136907985 no 2619 0.221675467848309 3766 779312 SGTC_607 4491-0986 66.8 µM -0.767447518371765 0.226691455523581 no 2620 0.221407742629932 3765 698981 YDR232W HEM1 SGTC_1732 st034308 51.822 µM -0.767591258175569 0.226650821384454 no 2621 0.221365028780606 3669 830119 SGTC_1233 0325-0408 14.2 µM -0.768755776519831 0.226321772588406 no 2622 0.221019153237146 3829 12874 SGTC_1470 k295-0292 231 µM -0.768978801102245 0.226258785087168 no 2623 0.220952947639731 3833 5045612 SGTC_742 0kpi-0133 140 µM -0.769048410027189 0.226239127882183 no 2624 0.220932286320933 3818 2728852 SGTC_1102 cgs 12066b 26.1 µM -0.769661181308533 0.226066126039422 no 2625 0.220750451297328 3793 6438352 A 5-HT1B full agonist. SGTC_2977 9011197 71.43 µM -0.772822883326854 0.225174681551747 no 2626 0.219813604339508 3839 2704722 SGTC_1516 st013856 110 µM -0.773269270357634 0.225048982976491 no 2627 0.219681519068999 3826 5281404 A mutagen and neurotoxin. SGTC_2079 5212404 121 µM -0.77334429215794 0.225027861415373 no 2628 0.219659324701959 3745 758462 SGTC_2749 bexarotene 57.39 µM -0.773792620032759 0.224901663060779 no 2629 0.219526718716828 3819 82146 An retinoic acid receptor inhibitor. SGTC_276 colchicine 750 µM -0.773815633099998 0.224895186270077 no 2630 0.21951991317504 3849 2833 A microtubule depolymerizer. SGTC_797 k781-0471 270 µM -0.774129994122366 0.224806723186504 no 2631 0.219426960863244 3773 23738129 SGTC_384 k007-0144 5.16 µM -0.77659444320805 0.224113896383291 no 2632 0.218699040502485 3789 6824886 SGTC_1989 st071868 50.2 µM -0.777305619380142 0.22391419022382 no 2633 0.218489240236721 3793 16414057 SGTC_419 nsc-638432 893 µM -0.777788396735905 0.223778678630531 no 2634 0.218346884747516 3776 368090 SGTC_34 0469-0683 81.75 µM -0.777854782583723 0.22376004832119 no 2635 0.218327313879154 3782 3690923 SGTC_3346 9158254 43.5805 µM -0.779891398805761 0.223188927551527 no 2636 0.217727400817142 3821 17639500 SGTC_3064 1327-0027 10 µM -0.780097849771824 0.223131079629633 no 2637 0.2176666410047 3674 16000455 YPR107C YTH1 SGTC_1815 st051655 58.2 µM -0.780811768279336 0.222931104229249 no 2638 0.217456605744 3736 5984156 SGTC_3185 9108267 49.47 µM -0.781562345039745 0.222720970634985 no 2639 0.217235911821882 3768 4910486 SGTC_281 1672-3440 14.9 µM -0.782021788135619 0.222592399364442 no 2640 0.217100884500228 3858 6833000 SGTC_758 0868-0029 16 µM -0.782948130541469 0.22233329897271 no 2641 0.216828786027689 3869 762687 SGTC_953 1188-0045 9.7 µM -0.784766347151728 0.221825239637562 no 2642 0.216295287269306 3829 6144426 SGTC_3014 9081533 49.47 µM -0.784865354556547 0.221797593318312 no 2643 0.216266258477735 3825 21367265 SGTC_1432 4049-0298 68.4 µM -0.788044562044272 0.220910894666385 no 2644 0.215335320335828 3817 741646 SGTC_2073 5212005 126 µM -0.788280361570872 0.220845209803815 no 2645 0.215266366073962 3652 691789 SGTC_2824 7998404 51.95 µM -0.788648806635634 0.220742597283651 no 2646 0.215158648269376 3787 837851 SGTC_255 tunicamycin 200.472 nM -0.788896654269898 0.220673586698861 no 2647 0.215086205675829 3777 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2564 betulinic acid 100 µM -0.789485777081409 0.220509601213693 no 2648 0.214914069696095 3808 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_3027 9089541 49.47 µM -0.790280341383748 0.220288540632405 no 2649 0.214682032485264 3809 9943819 SGTC_780 0109-0199 192 µM -0.790777583608207 0.22015026450235 no 2650 0.214536896559383 3851 610414 SGTC_2074 5212007 75.395 µM -0.793017063253864 0.219528113762414 no 2651 0.213883940706579 3691 758611 SGTC_1209 2323-2347 50.3 µM -0.793177893145601 0.219483472448005 no 2652 0.213837092773269 3771 5412760 SGTC_1464 k208-0027 110 µM -0.793320419893081 0.21944391586904 no 2653 0.213795581333845 3803 X1464 SGTC_662 k832-1615 104 µM -0.793362091450729 0.219432351204921 no 2654 0.213783445226125 3871 5878478 SGTC_1352 1496-0991 99 µM -0.794507761122758 0.219114542862693 no 2655 0.213449946273629 3818 3000039 SGTC_1267 0828-0272 9.49 µM -0.794539662027605 0.219105697352436 no 2656 0.213440664414377 3856 745334 SGTC_2948 9070189 9.45 µM -0.794906674052865 0.219003946713678 no 2657 0.213333895841506 3728 6473636 YDL196W YDL196W SGTC_2881 9058953 51.95 µM -0.796395280699339 0.218591523257127 no 2658 0.21290116019784 3807 17122249 SGTC_2384 9036245 200 µM -0.797631419401903 0.218249386963743 no 2659 0.212542206231028 3801 6462766 SGTC_2311 7694451 200 µM -0.799544690994498 0.217720443865797 no 2660 0.211987321776498 3797 2163142 SGTC_1511 0906-3109 28.5 µM -0.799874754435746 0.217629269377789 no 2661 0.211891682983041 3866 2882180 SGTC_960 1222-0186 7.7 µM -0.80026929194319 0.217520313924609 no 2662 0.211777395385725 3883 3126296 SGTC_385 1494-0393 12.4 µM -0.801428458759681 0.217200380695341 no 2663 0.211441822643417 3840 3090647 SGTC_2013 4024628 200 µM -0.801519642280038 0.217175225330334 no 2664 0.211415438707874 3849 5230760 SGTC_1054 3429-0080 167 µM -0.802048982649697 0.217029226158146 no 2665 0.211262312255427 3828 1162877 SGTC_2616 abietic acid 100 µM -0.802540456865475 0.216893721771776 no 2666 0.211120197831918 3830 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_406 estrone 100 µM -0.803097833983366 0.216740106492501 no 2667 0.210959094779917 3813 5870 A steroid. SGTC_2536 dehydroabietamide 32.04 µM -0.803824272275889 0.216539991769977 no 2668 0.210749234879244 3878 3983547 SGTC_974 1326-0144 138 µM -0.805023996443273 0.216209733349542 no 2669 0.210402916230801 3885 5411856 SGTC_2398 5228213 48.84 µM -0.806663045669626 0.215759009874166 no 2670 0.209930320113073 3826 80771 YMR134W ERG29 SGTC_1785 bathophenanthroline 24 µM -0.808707735080586 0.215197503302237 no 2671 0.209341638936484 3785 72812 An iron chelator. SGTC_772 k072-0172 35.3 µM -0.810163431790387 0.214798261571601 no 2672 0.208923125766958 3882 5861980 SGTC_502 l-744,832 89.3 µM -0.811115677302876 0.214537330164116 no 2673 0.20864962180635 3821 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1921 5740136 50 µM -0.811177120197849 0.214520500100602 no 2674 0.208631981429159 3776 1774243 SGTC_2842 9000675 19.48 µM -0.811547384977066 0.214419095678853 no 2675 0.208525696289259 3877 2989072 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.81295716700781 0.214033253849958 no 2676 0.208121308237144 3908 5393153 SGTC_2695 st077686 51.995 µM -0.814146981563255 0.213707929382473 no 2677 0.20778037703753 3908 2876092 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.814443150983661 0.213626994197249 no 2678 0.207695563523395 3842 6708760 SGTC_628 1636-0253 16 µM -0.815436497762673 0.213355669501529 no 2679 0.207411249932872 3876 4456143 SGTC_1091 telmisartan 47.6 µM -0.816447052438744 0.213079850865441 no 2680 0.207122247355674 3898 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_3024 9090631 49.47 µM -0.816486264299208 0.213069152657815 no 2681 0.207111038189763 3786 25236383 SGTC_2040 5100729 123 µM -0.81726026426025 0.212858045688081 no 2682 0.206889854768712 3866 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_340 k038-0059 454 µM -0.817868035682986 0.212692362827741 no 2683 0.206716271962656 3848 23733424 SGTC_941 3237-0776 460 µM -0.818235582986656 0.21259220333875 no 2684 0.206611340320465 3888 760008 SGTC_692 k241-0027 77.8 µM -0.818329398218745 0.212566642374528 no 2685 0.206584561920762 3887 3600480 SGTC_496 calpeptin 138 µM -0.819595824146506 0.212221766779579 no 2686 0.206223277489086 3848 73364 A calpain inhibitor. SGTC_220 paclitaxel 373.376 µM -0.822273682228741 0.211493605147848 no 2687 0.205460575813726 3806 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_260 nsc-65238 3.989 µM -0.822274298654358 0.211493437698345 no 2688 0.205460400437791 3824 3246252 SGTC_1883 5-benzylidenerhodanine 20 µM -0.822286236096473 0.211490194956216 no 2689 0.205457004197903 3875 1273210 SGTC_910 3454-3003 490 µM -0.822637783546461 0.211394712030577 no 2690 0.205357002788359 3776 820824 SGTC_442 cape 100 µM -0.826455395843051 0.210359446772598 no 2691 0.204272905219594 3805 5281787 SGTC_3289 9119912 71.43 µM -0.827483411007312 0.210081177773133 no 2692 0.203981560417431 3883 17014829 SGTC_2107 5363541 170.161 µM -0.829262806616608 0.209600032283256 no 2693 0.203477856080942 3852 244052 SGTC_1068 loratadine 26.9 µM -0.829480428427109 0.209541232235537 no 2694 0.203416303513292 3931 3957 A H1 histamine antagonist. SGTC_2243 6634756 200 µM -0.830712306120092 0.20920856958033 no 2695 0.203068086348591 3916 885676 SGTC_1306 1185-0270 9.02 µM -0.830984849958119 0.209135012449508 no 2696 0.202991093983623 3905 1548076 SGTC_1010 4112-3296 15.2 µM -0.831555374366417 0.208981082353936 no 2697 0.202829979947147 3951 704384 SGTC_810 3825-7150 143 µM -0.831918342505154 0.208883186631814 no 2698 0.202727518825809 3902 22330411 YGL099W LSG1 SGTC_796 1234-0020 70.7 µM -0.832069239203238 0.208842496407623 no 2699 0.202684931780064 3802 46495034 SGTC_2047 4141938 200 µM -0.833909065478234 0.208346751639461 no 2700 0.202166114172938 3875 3807862 SGTC_2279 7948423 32.93 µM -0.834399091307659 0.208214830383206 no 2701 0.202028064571218 3810 1247112 SGTC_2770 toltrazuril 17.5 µM -0.834491529576823 0.208189950339014 no 2702 0.202002029278235 3804 68591 Kills coccidiodes. SGTC_754 3474-0146 171 µM -0.835307656634636 0.207970363362692 no 2703 0.201772253755541 3857 24762078 SGTC_3233 9132340 49.47 µM -0.836138928307301 0.207746842209091 no 2704 0.201538375334687 3895 17682950 SGTC_3055 9094636 49.47 µM -0.836437173798371 0.207666681397579 no 2705 0.201454503525137 3881 25236176 SGTC_147 4466-0538 29.23 µM -0.837801850718961 0.207300124086505 no 2706 0.201070999584555 3926 6742687 YHR072W ERG7 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.838346050584727 0.207154056741583 no 2707 0.200918189775597 3858 15053 SGTC_874 0599-0792 117 µM -0.838573796089139 0.207092946206359 no 2708 0.200854260158749 3870 765305 SGTC_1791 st048313 56.1 µM -0.839618507231754 0.206812757473238 no 2709 0.200561159532278 3852 1204976 SGTC_682 0kpi-0099 17 µM -0.839876116853514 0.206743701767816 no 2710 0.200488924940836 3934 1714895 YML126C ERG13 SGTC_308 4092-1169 104 µM -0.840126861278157 0.206676499483137 no 2711 0.200418630381264 3828 2268590 YDL196W YDL196W SGTC_2654 protoveratrine a 100 µM -0.84437895808263 0.205538861242421 no 2712 0.199228838391934 3886 5702278 A heart drug and vasodilator. SGTC_2798 7813637 45.45 µM -0.84555062600341 0.205226038910681 no 2713 0.198901739585213 3910 956368 SGTC_333 3486-0131 40.1 µM -0.846221921502986 0.205046937995742 no 2714 0.198714477512465 3968 6744690 SGTC_894 0960-0238 55.9 µM -0.846502571604926 0.204972088398986 no 2715 0.198636219936336 3843 6741907 YDL195W SEC31 SGTC_2557 derrustone 83.84 µM -0.850273617373517 0.20396792396571 no 2716 0.197586490473527 3862 629853 An antioxidant. SGTC_568 1193-0097 7.48 µM -0.85164073863539 0.203604608352119 no 2717 0.197206760681845 3773 3646150 SGTC_1836 st055642 81 µM -0.851767444640894 0.203570955493119 no 2718 0.197171589360277 3913 8571 SGTC_3226 9131256 49.47 µM -0.851908408893924 0.203533519570958 no 2719 0.197132464664488 3793 17178073 SGTC_981 1488-1094 54.9 µM -0.853055422954587 0.203229059343891 no 2720 0.196814285027644 3880 3449522 SGTC_1658 st012944 20 µM -0.854438998902302 0.202862168720286 no 2721 0.196430897619235 3807 24207260 SGTC_318 1488-0629 67.2 µM -0.856694650342324 0.202264873967678 no 2722 0.195806830321539 3963 3662576 SGTC_3086 9117350 49.47 µM -0.857791222838203 0.201974882832924 no 2723 0.195503878614914 3836 2679265 SGTC_1941 st076221 61.8 µM -0.858288418372444 0.201843480363405 no 2724 0.19536661151324 3843 2828568 SGTC_2545 solidagenone 89.61 µM -0.860702878597613 0.201206097338904 no 2725 0.194700853640291 3718 6708572 An anti ulcer agent SGTC_2780 5215298 71.43 µM -0.863079339098048 0.200579925693349 no 2726 0.194046923360763 3960 2834131 SGTC_115 0527-0192 112.043 µM -0.864775342742366 0.200133763424499 no 2727 0.193581053569904 3949 4233931 SGTC_1679 SEC14.276 6.7 µM -0.867830205296161 0.199331636895258 no 2728 0.192743645909275 3939 1005053 YMR079W SEC14 SGTC_2493 resveratrol 26.09 µM -0.868519538744592 0.199150904124002 no 2729 0.192554990376989 3802 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_3211 9128781 49.47 µM -0.868938483547314 0.199041111396236 no 2730 0.192440389484387 3976 17194361 SGTC_1372 2752-0194 270 µM -0.870856072361097 0.198539035210219 no 2731 0.191916372214236 3893 823334 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.871303848225515 0.198421905595398 no 2732 0.191794134928504 3972 6710655 SGTC_967 1306-0166 352 µM -0.871380979775914 0.198401733665198 no 2733 0.191773083780905 3869 4437607 SGTC_201 4262-0159 12.803 µM -0.871645077501989 0.19833267453236 no 2734 0.191701015559082 3962 1341029 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.872814046104227 0.198027174218313 no 2735 0.191382221168485 3932 442882 SGTC_1852 st056254 31.4 µM -0.874485815836913 0.197590765119202 no 2736 0.190926870690938 3881 442583 SGTC_65 0798-0905 34.986 µM -0.87508071042522 0.197435610516305 no 2737 0.190764995953257 3996 3602145 SGTC_2499 avocadenofuran 51.48 µM -0.877890817372743 0.196703702312659 no 2738 0.190001486455305 3922 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_181 1447-1644 8.07 µM -0.878968381236904 0.196423481197011 no 2739 0.189709209957015 3955 534600 SGTC_2893 9048488 25.97 µM -0.879462948927964 0.196294949623554 no 2740 0.18957515693596 3979 6467338 SGTC_899 1083-0020 478 µM -0.88249027405299 0.195509299878849 no 2741 0.188755868503783 4022 767123 SGTC_3176 9106582 49.47 µM -0.882516012128527 0.195502628544987 no 2742 0.188748912347929 3871 17018027 SGTC_1087 pterostilbene 9.05 µM -0.882661958791043 0.195464801644785 no 2743 0.188709470750262 4007 5281727 Similar to reservatol, lowers cholesterol. SGTC_2764 methyldopa 94.69 µM -0.883266052671072 0.19530827803834 no 2744 0.188546270436988 3930 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1114 scopoletin 1.73284 µM -0.883847465770923 0.195157703070143 no 2745 0.188389279714721 3952 5280460 A coumarin with genotoxic properties. SGTC_1061 3448-9325 110 µM -0.884020246031109 0.195112969861344 no 2746 0.188342641859716 3846 723482 SGTC_680 0417-1641 114 µM -0.884187963932688 0.195069553270585 no 2747 0.188297377279042 3913 2835990 SGTC_762 1165-0429 115 µM -0.884990790160736 0.194861809591773 no 2748 0.188080799321195 3931 5967793 SGTC_237 nikkomycin 200 µM -0.887362821749603 0.194248796314823 no 2749 0.187441796526327 3951 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2629 bisabolol 100 µM -0.889270472655701 0.193756647785054 no 2750 0.186928868223938 3987 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_3135 9127742 49.47 µM -0.890265674425676 0.193500200987008 no 2751 0.186661623890529 4036 3643468 SGTC_2128 5255449 168.493 µM -0.890710027444614 0.193385765560747 no 2752 0.186542376947678 3958 736008 SGTC_876 0720-0963 56.8 µM -0.893322616561175 0.192713773937492 no 2753 0.185842214863809 4006 765861 SGTC_139 0099-0334 718.624 µM -0.894798660569107 0.19233474795331 no 2754 0.18544736324085 4002 97690 SGTC_2664 lyso-paf C-16 73.48 µM -0.897642541135086 0.191605768512304 no 2755 0.18468807572628 3937 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_538 2922-0838 53.3 µM -0.899010048350521 0.191255835134236 no 2756 0.18432365421471 3937 777039 SGTC_2643 anethole 100 µM -0.899949548082225 0.19101565238168 no 2757 0.184073550162689 3972 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_252 miconazole 1.30953 nM -0.900135156623719 0.190968223520945 no 2758 0.184024164350081 3895 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1295 1013-0063 9.78 µM -0.902552593547612 0.190351151726056 no 2759 0.183381698177265 3970 6826038 SGTC_2620 irigenin 100 µM -0.903136185972267 0.190202368397214 no 2760 0.183226810482516 4033 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.903701172167898 0.190058396703128 no 2761 0.183076938705619 3990 616764 SGTC_1971 st069429 63.5 µM -0.909713596509989 0.188530442249172 no 2762 0.18148678590859 3964 1246522 YGL099W LSG1 SGTC_979 1426-2828 121 µM -0.913077017157581 0.187679000008664 no 2763 0.180601018436524 4096 747872 SGTC_1854 st056233 32.9 µM -0.913962863143636 0.18745514594532 no 2764 0.180368179902641 3878 5393174 SGTC_1842 st055362 61.2 µM -0.9168754638042 0.186720293171613 no 2765 0.17960395131267 3955 676032 SGTC_2324 6149169 200 µM -0.918195449591607 0.186387847145024 no 2766 0.179258275268973 3905 2888231 SGTC_3145 9085516 49.47 µM -0.918843855085593 0.186224676866228 no 2767 0.179088625089156 4054 25236195 SGTC_1226 3909-7979 35.4 µM -0.918855262598899 0.18622180697506 no 2768 0.179085641307789 4006 6615510 SGTC_2183 6420625 130.508 µM -0.920113669050138 0.185905386588557 no 2769 0.17875668100166 3977 2897619 SGTC_2048 5246248 200 µM -0.92269123533437 0.185258311274588 no 2770 0.178084067335451 3992 677046 SGTC_2852 9023854 51.95 µM -0.924513332399529 0.184801734711314 no 2771 0.177609556616661 4085 19798528 SGTC_2148 5546263 113.568 µM -0.925585480091758 0.184533405750916 no 2772 0.17733072101616 3985 792097 SGTC_335 4077-0256 27.6 µM -0.926096428116127 0.184405614868308 no 2773 0.177197935043944 3986 3121989 SGTC_3223 9129970 49.47 µM -0.926103917171719 0.184403742224206 no 2774 0.177195989243557 4019 17248386 SGTC_706 4262-0057 46.9 µM -0.929837981032975 0.183471510557545 no 2775 0.176227488963975 3985 883298 SGTC_2331 7980721 200 µM -0.930592649595871 0.183283460443447 no 2776 0.176032159076372 3983 2981221 SGTC_840 0245-0196 390 µM -0.931248182174231 0.183120210853497 no 2777 0.175862599719079 4104 3827528 SGTC_1690 st023502 41.2 µM -0.932334319138847 0.182849926052766 no 2778 0.175581888457022 4011 24207482 SGTC_3126 9127922 49.47 µM -0.932337614609794 0.182849106355065 no 2779 0.175581037177402 4071 45595682 SGTC_73 0327-0325 16.231 µM -0.93633221724615 0.181857197180948 no 2780 0.174551082680179 3914 53298 SGTC_360 0957-0399 1.01 µM -0.938814696670583 0.181242465865342 no 2781 0.173912945963546 4043 6752301 YPR165W RHO1 SGTC_1583 clindamycin 39.6 µM -0.938997672303826 0.181197207536704 no 2782 0.173865969718599 3999 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_3347 9188721 44.724 µM -0.940082226007794 0.180929092639311 no 2783 0.173587692542968 4051 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.940297065386576 0.18087601124376 no 2784 0.173532602232059 4017 364106 SGTC_164 4100-3994 89.624 µM -0.94149162080577 0.180581044754648 no 2785 0.173226490632919 3952 4615967 SGTC_749 1000-0129 128 µM -0.942898741650641 0.180233977601532 no 2786 0.172866349309482 4085 708470 SGTC_1070 indatraline 8.81 µM -0.943213626481022 0.180156368441624 no 2787 0.172785822437891 4022 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_719 2810-4230 27.3 µM -0.943294995584135 0.180136316940328 no 2788 0.172765017450186 4016 721079 SGTC_309 k408-0051 1.48 µM -0.94483289256078 0.179757601903784 no 2789 0.172372098147788 3966 3640463 SGTC_1782 st039423 80.636 µM -0.945481636306145 0.179597995539171 no 2790 0.172206520851797 4052 2068169 SGTC_1607 st000305 50.6 µM -0.945755560227509 0.179530630500157 no 2791 0.172136638397353 4048 5457690 SGTC_962 1254-0300 21.5 µM -0.946364934329038 0.179380826482625 no 2792 0.171981242064931 4005 7340576 SGTC_2106 5357045 167.29 µM -0.94670768271457 0.179296602301147 no 2793 0.171893877253821 4058 668842 SGTC_881 0833-0569 170 µM -0.947556999991633 0.179088005209366 no 2794 0.171677512761282 4027 5418700 SGTC_154 3389-1638 511.116 µM -0.950273460551073 0.178421852882742 no 2795 0.170986660203365 4036 5238686 SGTC_608 k048-0125 159 µM -0.950676800811709 0.178323075804789 no 2796 0.170884234211825 4083 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1187 1391-0724 117 µM -0.951144714056485 0.178208528138807 no 2797 0.170765459474452 4088 6997986 SGTC_49 0717-0965 32.132 µM -0.951491125508832 0.178123754644695 no 2798 0.170677560704466 4108 5889349 YGL099W LSG1 SGTC_83 0170-0301 39.027 µM -0.952934963236316 0.177770693846754 no 2799 0.170311511942551 3980 3089716 SGTC_1763 st044482 94.5 µM -0.95568164277576 0.177100269610518 no 2800 0.169616549856906 4042 88505 SGTC_815 1582-0027 36.9 µM -0.957394861257738 0.176682908000839 no 2801 0.169183995596417 4092 3128206 SGTC_2307 7538926 6.34 µM -0.957690497999296 0.176610950132193 no 2802 0.16910942480079 4050 96582 SGTC_399 oxolinic acid 75 µM -0.958094760553953 0.176512582784784 no 2803 0.169007488626388 4000 4628 A DNA gyrase inhibitor. SGTC_2735 sertaconazole 140 nM -0.958593654808005 0.176391236921716 no 2804 0.168881745164673 4158 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_153 4077-0274 519.67 µM -0.958653571844716 0.176376666873945 no 2805 0.168866647459837 4031 3121976 SGTC_3251 9135047 49.47 µM -0.958728191397358 0.176358522674628 no 2806 0.168847846274152 4050 17682963 SGTC_2101 5377231 179.231 µM -0.958907113737046 0.176315021427458 no 2807 0.168802770376819 4090 2844213 SGTC_1606 st000094 49.2 µM -0.959234949494274 0.176235332597797 no 2808 0.168720198794021 4076 1242210 SGTC_1274 0865-0114 173 µM -0.959764613933058 0.176106632337905 no 2809 0.168586847731038 4047 870624 SGTC_218 alverine citrate 93.75 µM -0.961072367944782 0.175789123229451 no 2810 0.168257891050402 4080 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1648 st011736 69.8 µM -0.96331445684436 0.175245611669782 no 2811 0.167694870221019 4055 2855514 SGTC_2641 levomentholum 100 µM -0.96405434292874 0.175066487753559 no 2812 0.167509340723033 4034 16666 SGTC_3099 9120367 49.47 µM -0.964592664105019 0.174936235042214 no 2813 0.167374437599119 4065 24824940 SGTC_618 k072-0232 33.2 µM -0.964651757278801 0.174921940547604 no 2814 0.167359633133341 4080 5872756 YGL099W LSG1 SGTC_940 3232-1287 54.8 µM -0.966386947963385 0.174502532615876 no 2815 0.166925296346742 3962 1585493 YIL048W NEO1 SGTC_1719 st032227 49.2 µM -0.966591937729927 0.17445302734881 no 2816 0.16687403327706 4063 3125804 SGTC_1026 k007-1105 30.6 µM -0.966625768059103 0.174444858142658 no 2817 0.166865574091981 4030 7066794 SGTC_2412 st077135 33.4 µM -0.967401353962246 0.174257639554394 no 2818 0.166671716738095 4149 13258915 SGTC_3234 9132280 49.47 µM -0.967728707452687 0.17417865806662 no 2819 0.166589938512309 4082 17612295 SGTC_2757 clomiphene 4.22 µM -0.967852368566908 0.174148827927001 no 2820 0.16655905269541 4124 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2550 chrysin dimethyl ether 71.87 µM -0.96808676306285 0.174092295049683 no 2821 0.16650052005804 3855 88881 An O-methylated flavonoid and antioxidant. SGTC_80 0159-0065 512.242 µM -0.970061710420219 0.173616426982361 no 2822 0.16600786658068 3926 1548079 SGTC_1338 1486-1223 76 µM -0.977634969546503 0.171799314231541 no 2823 0.16412744771022 4090 3444526 SGTC_674 0498-0004 451 µM -0.978086276407297 0.171691413401953 no 2824 0.16401582737189 4055 4231473 SGTC_1835 st008666 49.2 µM -0.97942761946368 0.171370973617763 no 2825 0.163684367897167 4014 690455 SGTC_3062 9077494 49.47 µM -0.980539945595744 0.171105534918288 no 2826 0.163409830888549 4049 16459633 SGTC_2176 5809774 33.9695 µM -0.981956381499268 0.17076790615561 no 2827 0.16306066869479 4025 2870539 SGTC_2944 9067346 25.62 µM -0.983177536405038 0.170477168048118 no 2828 0.162760034302099 4031 6473075 SGTC_3246 9135460 32.98 µM -0.983638679000352 0.170367459625139 no 2829 0.162646600091575 4035 41446951 SGTC_1403 3909-7815 62.9 µM -0.985097785034033 0.170020628068152 no 2830 0.162288020632943 4017 6615483 SGTC_2052 5265182 7.135 µM -0.986507492075866 0.169685968887819 no 2831 0.16194207029479 4085 1239884 SGTC_231 b-estradiol 524 µM -0.986796119203359 0.169617502031238 no 2832 0.161871298806439 4051 450 A steroid. SGTC_1753 st043925 64 µM -0.988016444840437 0.169328217655233 no 2833 0.161572297213747 4120 670181 SGTC_562 3772-2733 112 µM -0.98926149242549 0.169033399391856 no 2834 0.161267609613783 4095 2876874 YIL048W NEO1 SGTC_1456 k015-0012 13 µM -0.993257709099356 0.168089353008815 no 2835 0.160292190715348 4063 2989616 SGTC_2659 sanguinarine 24.21 µM -0.993893100851198 0.16793956442214 no 2836 0.160137456769358 4015 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1795 st049545 62.3 µM -0.994120044850988 0.167886084997457 no 2837 0.160082213847368 4010 5291882 SGTC_1849 st056239 19.2 µM -0.994749983727682 0.167737697160838 no 2838 0.159928938836991 4088 5393181 SGTC_822 1487-0950 154 µM -0.995884091605544 0.167470760691926 no 2839 0.159653232838884 4111 1958375 SGTC_3296 9122258 64.045 µM -0.997929285072757 0.166990073031465 no 2840 0.159156825090637 4089 4730474 SGTC_3227 9130768 49.47 µM -1.00040585988601 0.166409188910385 no 2841 0.158557067649767 4138 17720899 SGTC_258 haloperidol 50.781 µM -1.00055939911274 0.16637321906831 no 2842 0.158519933582481 4093 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3201 9113999 49.47 µM -1.00132601286768 0.166193698546559 no 2843 0.158334610366867 4118 16649224 SGTC_2621 lithochol-11-enic acid 100 µM -1.00592610527192 0.165119108667819 no 2844 0.157225558771904 4023 6708711 SGTC_1467 k284-1082 293 µM -1.01241005030035 0.1636121030486 no 2845 0.155671017468698 4067 3334705 SGTC_739 1486-1183 203 µM -1.01316412419217 0.163437421875643 no 2846 0.155490886716494 4111 4346692 SGTC_1431 4049-0260 9.09 µM -1.01491831324228 0.1630315329239 no 2847 0.155072383898613 4081 3854841 SGTC_2721 ifenprodil 61.44 µM -1.01735517129205 0.16246877450279 no 2848 0.154492249766341 4103 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2950 9072895 21.46 µM -1.01873175252324 0.162151431670676 no 2849 0.154165166897542 4078 17332245 SGTC_3333 9141820 12.094 µM -1.02063122812435 0.161714209350003 no 2850 0.153714594202372 4102 1939433 SGTC_1261 0712-0010 12.7 µM -1.02081242877775 0.161672540667136 no 2851 0.153671657373441 4150 2840123 SGTC_1975 st070967 30.8 µM -1.02263344742128 0.161254170023146 no 2852 0.153240594520703 4095 261391 SGTC_3030 9087619 49.47 µM -1.02311213526825 0.161144311025213 no 2853 0.153127414936026 4149 25236973 SGTC_2568 diosmetin 100 µM -1.02320027733466 0.161124087720815 no 2854 0.153106580919532 4173 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_251 melphalan 456.522 µM -1.02411568588331 0.160914154415731 no 2855 0.152890318169514 4130 460612 A DNA alkylator. SGTC_253 dyclonine 31.25 µM -1.02439250489827 0.160850705882343 no 2856 0.152824960345477 4208 3180 An oral anasthetic. SGTC_770 0389-1121 67.2 µM -1.02491821878573 0.16073025416103 no 2857 0.15270088868737 4216 6753108 SGTC_1611 st001856 99.4 µM -1.02506115655802 0.160697514403493 no 2858 0.152667166064508 4094 647478 SGTC_1423 4048-0112 5.59 µM -1.02792365282141 0.160042779410404 no 2859 0.151992871200337 4149 X1423 SGTC_778 3456-2434 196 µM -1.02948608411218 0.159686143494476 no 2860 0.151625657845946 4084 5539063 SGTC_3257 9139206 32.98 µM -1.03229054155181 0.159047311808404 no 2861 0.1509680153242 4118 4910041 SGTC_1631 benzylvanillin 81.9 µM -1.03268427775692 0.158957756259213 no 2862 0.15087583677056 4212 75506 SGTC_2068 5226020 147 µM -1.03270710863137 0.158952564376139 no 2863 0.150870492927693 4151 1810509 SGTC_1304 1165-0502 251 µM -1.03455631355711 0.158532412664448 no 2864 0.150438082468024 4127 767425 SGTC_1079 idarubicin 2.36 µM -1.03561755448024 0.15829162087574 no 2865 0.150190299514826 4142 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_248 streptozotocin 5.23457 mM -1.03595558539868 0.158214973282356 no 2866 0.150111431802299 4152 5300 DNA alkylating agent. SGTC_182 3448-4371 550.524 µM -1.03598583854414 0.158208114651377 no 2867 0.150104374633366 4003 3491403 SGTC_2428 5615643 7.78 µM -1.03664299143535 0.158059180966679 no 2868 0.149951134776267 4167 2253075 SGTC_2160 5660466 132.927 µM -1.03821587872115 0.157703083931311 no 2869 0.149584780877331 4022 2859134 SGTC_3043 9092303 49.47 µM -1.03871998137866 0.15758906818389 no 2870 0.149467492744681 4128 25236084 SGTC_1023 4482-3888 16 µM -1.04017229647682 0.157260892734354 no 2871 0.149129929961386 4155 3303168 SGTC_1173 0443-0020 122 µM -1.04028105071636 0.15723633594926 no 2872 0.149104672632813 4117 5331295 SGTC_57 miconazole 162.5 nM -1.04128089714785 0.157010688058338 no 2873 0.1488725999406 4032 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_512 prima-1 270 µM -1.04195942899734 0.156857676649592 no 2874 0.148715244593433 4139 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2256 7954252 200 µM -1.04206204023674 0.156834545984136 no 2875 0.148691458151448 4155 2972920 SGTC_2692 st077426 47.7 µM -1.04349862529315 0.156510946108897 no 2876 0.148358708586228 4155 25238571 SGTC_2353 9059630 146.67 µM -1.0441189474463 0.156371350617414 no 2877 0.14821518031585 4177 4779114 SGTC_1799 st045822 46.1415 µM -1.04412927044622 0.156369028253453 no 2878 0.148212792597375 4105 3674992 SGTC_2104 5389443 200 µM -1.04671573899192 0.15578786662953 no 2879 0.1476153512507 4181 2244536 SGTC_2669 eugenol 100 µM -1.04700950978644 0.155721948542247 no 2880 0.147547596089104 4123 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2450 5739737 12.93 µM -1.04706093227246 0.155710411942244 no 2881 0.147535738173386 4179 2262825 SGTC_621 3584-0052 32.1 µM -1.050249935766 0.154996062493676 no 2882 0.146801608146045 4157 2273927 SGTC_3295 9122362 53.5725 µM -1.05248649674227 0.154496357151009 no 2883 0.146288201295242 4173 4730473 SGTC_1508 1080-0625 72.9 µM -1.05302667960791 0.154375826224175 no 2884 0.146164382276468 4014 767111 SGTC_3005 9076496 71.4286 µM -1.05398428861197 0.154162307901713 no 2885 0.145945055197831 4112 21368410 SGTC_132 0417-1715 25.805 µM -1.05422701163354 0.154108218933708 no 2886 0.145889498000612 4118 6769098 SGTC_890 0929-0006 47.2 µM -1.05732046479885 0.153419966228168 no 2887 0.145182678242407 4120 1378169 SGTC_3074 9116018 49.47 µM -1.06019235275583 0.152782834170193 no 2888 0.144528549713834 4211 17027303 SGTC_2202 7226349 200 µM -1.06028646987475 0.15276198390521 no 2889 0.144507146360346 4110 844334 SGTC_2794 7785382 27.27 µM -1.06029958534251 0.152759078515837 no 2890 0.14450416391636 4127 2205081 SGTC_1035 k081-0041 55.2 µM -1.06087900693686 0.152630759367899 no 2891 0.144372445426083 4180 731709 SGTC_705 1124-0212 310 µM -1.0628248341806 0.152200358417224 no 2892 0.143930697586738 4130 9554485 SGTC_180 1486-1293 102.781 µM -1.06638262374716 0.151415490318776 no 2893 0.143125356651322 4053 4140536 SGTC_781 4335-2806 94.4 µM -1.06662618249217 0.151361858516552 no 2894 0.143070336263058 4223 845254 SGTC_1019 4262-0212 3.4 µM -1.06689410587149 0.151302876199201 no 2895 0.143009828364804 4179 4677213 SGTC_2159 5658611 73.75 µM -1.06823866140878 0.151007108271888 no 2896 0.142706434675294 4157 793844 SGTC_261 5-fluorouridine 15.376 µM -1.0689051424374 0.150860642170386 no 2897 0.142556207268756 4193 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.07275000149815 0.15001754146936 no 2898 0.141691649662055 4160 5106787 A p450 inhibitor. SGTC_1790 st045711 43.5 µM -1.07425386286173 0.149688631092744 no 2899 0.141354458639003 4169 585119 SGTC_654 1124-0271 80.9 µM -1.07447914244855 0.14963940153158 no 2900 0.14130399404331 4148 5403748 SGTC_1746 st038117 42 µM -1.07460860823525 0.149611114714132 no 2901 0.141274998102512 4214 2898218 SGTC_1933 st074711 15.9 µM -1.076255199893 0.149251664239718 no 2902 0.14090656934465 4156 17250958 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.07631523893216 0.149238568640811 no 2903 0.140893147795868 4232 1609 A potent and irreversible inhibitor of serine proteases. SGTC_595 3909-8003 73.7 µM -1.07757136964864 0.148964759794708 no 2904 0.140612542384573 4241 699517 SGTC_2828 7998861 71.43 µM -1.07990102741785 0.14845783464782 no 2905 0.140093127858222 4156 2988188 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.08095012334859 0.148229932311055 no 2906 0.13985965033401 4198 551469 SGTC_2717 st081029 62.2815 µM -1.08139076921496 0.148134277615177 no 2907 0.139761662999566 4152 5292846 SGTC_551 k048-0028 34.9 µM -1.08144723072775 0.148122024026855 no 2908 0.139749110909932 4168 6836383 SGTC_2219 9098279 200 µM -1.08195359809423 0.148012159713153 no 2909 0.13963657346592 4104 902349 SGTC_2034 5197015 53.07 µM -1.08245423515037 0.147903592311898 no 2910 0.139525370149008 4182 780676 SGTC_3139 9095020 49.47 µM -1.08412239616874 0.147542222267978 no 2911 0.13915526697644 3907 25236292 SGTC_2350 9023895 38.85 µM -1.08516585009343 0.147316482098152 no 2912 0.138924103162875 4197 2997209 SGTC_198 3454-2873 16.191 µM -1.08670662669701 0.146983574913852 no 2913 0.138583242226143 4165 710957 SGTC_1045 1348-1485 165 µM -1.08779384031044 0.146748970440777 no 2914 0.138343064704135 4159 6810614 SGTC_64 000l-0018 272.079 µM -1.09091527275205 0.146076808645022 no 2915 0.137655083058988 4108 6811119 SGTC_816 0325-0417 81.3 µM -1.10061661505408 0.144000964917629 no 2916 0.135531775569432 4213 68101 SGTC_194 1486-1323 56.904 µM -1.10151955623261 0.143808775248347 no 2917 0.135335298953636 4263 5178754 SGTC_2834 9001755 58.44 µM -1.10380251440498 0.143323623250493 no 2918 0.134839406954528 4118 2989575 SGTC_2001 4023502 57.655 µM -1.10394172623339 0.143294075106471 no 2919 0.13480920848164 4237 108941 YCR052W RSC6 SGTC_2036 5160441 105 µM -1.10588187804021 0.142882700037685 no 2920 0.134388824743612 4172 134534 YIL048W NEO1 SGTC_1298 1079-1278 263 µM -1.10658131411132 0.142734592853448 no 2921 0.134237494923052 4175 2840950 SGTC_2897 9048598 12.99 µM -1.10702204189723 0.142641321061145 no 2922 0.134142199297214 4182 6467404 SGTC_1837 st055472 66.5 µM -1.11076650547723 0.141850537976496 no 2923 0.133334433634369 4289 676091 SGTC_2374 9071832 200 µM -1.11341819036374 0.141292334701596 no 2924 0.132764433062459 4137 17381698 SGTC_2063 5246145 200 µM -1.11356538229679 0.141261393170812 no 2925 0.132732842232414 4244 711240 SGTC_548 1436-0017 110 µM -1.11667010671902 0.140609812643403 no 2926 0.132067701922965 4270 9677137 SGTC_669 0108-0021 26.2 µM -1.11868834898721 0.14018734505906 no 2927 0.131636558704545 4138 17201 SGTC_17 0960-0276 49.807 µM -1.12509644526908 0.138851692629569 no 2928 0.130274083745269 4204 6821114 SGTC_893 0958-0369 48.9 µM -1.12609282199008 0.138644796879487 no 2929 0.130063115999481 4131 6819948 SGTC_2763 lisinopril 49.32 µM -1.12625036091706 0.138612103455978 no 2930 0.130029781168574 4103 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1834 st055981 52.8 µM -1.12741647821828 0.138370267125195 no 2931 0.129783217643722 4227 471719 YDL150W RPC53 SGTC_1150 3909-7983 10.9 µM -1.12852606140108 0.138140422332491 no 2932 0.129548908446028 4197 23965914 SGTC_456 gingerol 170 µM -1.12903335580861 0.138035425517207 no 2933 0.129441881442187 4264 442793 A herb. SGTC_1513 0337-0559 19 µM -1.13066352942072 0.137698390303734 no 2934 0.129098368583799 4204 775073 SGTC_3007 9078383 71.4286 µM -1.13081666813252 0.137666758054787 no 2935 0.129066131450205 4207 6496995 SGTC_1590 st077108 57.8 µM -1.1325984480557 0.137299079091802 no 2936 0.128691460338418 4240 5489485 SGTC_346 4513-0042 7.16 µM -1.13499250706749 0.136806110147876 no 2937 0.128189228934134 4190 2827372 SGTC_2519 cryptotanshinone 88.04 µM -1.13525042124325 0.136753074435654 no 2938 0.128135204416385 4207 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_3035 9091303 49.47 µM -1.1372231918586 0.136347872286858 no 2939 0.127722497080845 4298 25237002 SGTC_376 3970-0862 59.1 µM -1.1375817968717 0.136274304033039 no 2940 0.127647575588841 4269 3135186 SGTC_3002 9075603 71.4286 µM -1.13909627502275 0.135963906605395 no 2941 0.127331500496757 4167 20105405 SGTC_120 rhodamine 6G 52.259 µM -1.14182652173384 0.135405556953251 no 2942 0.126763067916376 4238 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2876 9059903 25.97 µM -1.14259339074619 0.135249011333016 no 2943 0.126603725461593 4227 6916095 SGTC_2443 5493264 126.67 µM -1.14341582506275 0.135081260765437 no 2944 0.126432992564541 4271 5340055 SGTC_1278 0874-0585 172 µM -1.14407825660502 0.13494624948428 no 2945 0.126295592060828 4309 766306 SGTC_3058 9093861 49.47 µM -1.1457195109004 0.134612141561642 no 2946 0.125955614092179 4260 17217477 SGTC_2227 7312221 64.1025 µM -1.14653929096512 0.134445472831299 no 2947 0.125786039777697 4331 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_3061 glucosamine 200 µM -1.14676101427218 0.134400418822042 no 2948 0.125740202924563 4173 91431 and experimental redox chemotherapeutic SGTC_1629 st005085 44.9 µM -1.14733247160816 0.134284346915635 no 2949 0.125622119284959 4185 24207091 SGTC_1524 corynanthine 62.1 µM -1.14843243009049 0.134061122009976 no 2950 0.125395046152037 4344 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1632 st005650 90 µM -1.14896194798744 0.133953752927288 no 2951 0.125285835804262 4262 2759605 SGTC_825 1988-2224 89.6 µM -1.15042243608458 0.133657919554788 no 2952 0.124984961856412 4224 1180859 SGTC_1288 0973-0013 65.5 µM -1.1537881041399 0.132977888342238 no 2953 0.124293526199975 4268 4315430 SGTC_137 0438-0332 85.389 µM -1.15453529724491 0.132827242083839 no 2954 0.124140388040359 4197 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_886 0866-0150 153 µM -1.15543980221949 0.132645036491942 no 2955 0.123955185291864 4313 271463 SGTC_3186 9110464 49.47 µM -1.15804875212432 0.132120448348804 no 2956 0.123422070918493 4246 17018021 SGTC_2338 7999974 200 µM -1.15962535311851 0.131804131536145 no 2957 0.12310068701028 4251 315925 SGTC_1349 flufenamic acid 69 µM -1.15992465532686 0.131744140954835 no 2958 0.12303974174133 4179 3371 A non-steroidal anti-inflammatory. SGTC_686 1319-0111 510 µM -1.16015779078829 0.131697425547655 no 2959 0.122992284301199 4291 4562600 SGTC_2581 avocatin a 64 µM -1.16345254484592 0.131038448756141 no 2960 0.122322970637979 4215 6710728 A skin care supplement. SGTC_1812 st052057 4.327 µM -1.16374907605425 0.130979252114211 no 2961 0.12226285737412 4265 3645418 SGTC_1330 1469-0054 61.8 µM -1.16592393560685 0.130545648786626 no 2962 0.121822600279428 4253 7102664 SGTC_1038 k292-0204 154 µM -1.16618252473116 0.130494159788577 no 2963 0.121770328229531 4206 4454212 SGTC_1531 st059297 52.4 µM -1.16773351148652 0.130185629660379 no 2964 0.12145713742036 4280 7566702 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.16947044719543 0.129840709218036 no 2965 0.12110707062767 4257 1377 SGTC_1951 sophoraflavanone G 9.2 µM -1.16956385119287 0.129822179010497 no 2966 0.121088265860148 4224 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2781 5567276 71.43 µM -1.17139942855683 0.12945839452826 no 2967 0.120719130932473 4286 2853274 SGTC_3173 9105693 49.47 µM -1.17208165418767 0.129323367637939 no 2968 0.120582137365815 4269 17096658 SGTC_1855 st056195 39.6 µM -1.17540359418736 0.12866728031803 no 2969 0.11991664311757 4197 4028379 SGTC_1526 st051518 75 µM -1.17743721213506 0.128266779817499 no 2970 0.119510522267148 4250 673993 SGTC_653 0203-0016 55.2 µM -1.1777216757518 0.128210826671272 no 2971 0.119453791303648 4327 295302 SGTC_1759 st043059 70 µM -1.17845891123355 0.128065893546558 no 2972 0.11930685187368 4267 669426 SGTC_869 0564-0080 44.1 µM -1.17895376571219 0.127968673960809 no 2973 0.119208293313473 4280 6843321 SGTC_561 1550-0330 72.9 µM -1.17981339559536 0.127799912176709 no 2974 0.119037220274828 4212 6812934 SGTC_1634 st006576 41 µM -1.18435002786981 0.126911846850617 no 2975 0.118137266458416 4245 3915356 SGTC_1650 st011916 45.8 µM -1.18610611821772 0.126569240550767 no 2976 0.117790197339496 4203 242528 SGTC_987 1497-1013 404 µM -1.19004068327258 0.125803962588328 no 2977 0.117015201119618 4287 1676435 SGTC_935 2996-0153 430 µM -1.19390210869797 0.125056054161315 no 2978 0.116258131286294 4279 23738523 SGTC_2954 9074818 52.69 µM -1.19636427447056 0.124580788861823 no 2979 0.11577721821003 4308 16648742 SGTC_3131 9127911 49.47 µM -1.19660167856109 0.124535030214022 no 2980 0.115730922957261 4328 45595681 SGTC_2709 st078560 56 µM -1.19857391254297 0.124155344595075 no 2981 0.115346833512959 4277 17250903 SGTC_1339 1486-1321 22.7 µM -1.19925117088401 0.124025148855392 no 2982 0.115215147732894 4306 3469382 SGTC_1685 st024049 53.0905 µM -1.19960693102199 0.123956796025615 no 2983 0.115146016738172 4299 1941139 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.1997132650077 0.12393637100582 no 2984 0.115125359738256 4222 1241132 A phosphatase inhibitor. SGTC_2326 6164455 177.58 µM -1.20051367622645 0.123782700694169 no 2985 0.114969952202965 4244 2888790 SGTC_2182 6325192 200 µM -1.20545609373759 0.122836764672017 no 2986 0.114013639006861 4280 736248 SGTC_113 0099-0221 2.5 µM -1.20679161360327 0.122582029957163 no 2987 0.113756203293284 4257 89219 SGTC_2401 5128683 200 µM -1.20703723664082 0.122535220628629 no 2988 0.113708901971199 4308 708373 SGTC_1798 st045719 60.953 µM -1.21031811327921 0.121911173713207 no 2989 0.113078424926906 4241 3980186 SGTC_2050 5263056 171 µM -1.21668716755657 0.120706113757139 no 2990 0.111861631658325 4283 763468 YGL055W OLE1 SGTC_1472 k841-0093 193 µM -1.21787768352674 0.120481795018662 no 2991 0.111635228946565 4418 X1472 SGTC_856 0433-0016 11.3 µM -1.21800062678733 0.120458646607052 no 2992 0.111611867279321 4342 3911780 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.22222356464816 0.119665430280528 no 2993 0.110811547471782 4226 5355888 SGTC_1184 1269-1718 139 µM -1.2248880990277 0.119166836458374 no 2994 0.110308692510334 4357 5403821 SGTC_3339 9145883 14.936 µM -1.22536450129105 0.119077845728604 no 2995 0.110218957873599 4212 2030670 SGTC_3236 9132701 49.47 µM -1.22645735690852 0.118873880376605 no 2996 0.110013306562353 4297 24282524 SGTC_247 mechlorethamine 29.705 µM -1.2273605582785 0.118705497518057 no 2997 0.109843551902301 4238 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1135 dihydrocapsaicin 536.708 nM -1.22921965650395 0.118359438386253 no 2998 0.109494730492936 4217 107982 A Capsaicinoid. SGTC_2812 7970281 58.44 µM -1.22965737897591 0.118278063006139 no 2999 0.109412716734393 4343 2233435 SGTC_731 3966-0296 387 µM -1.2316219595133 0.11791332223988 no 3000 0.109045167020166 4317 660956 SGTC_1025 k007-0731 70 µM -1.23181589337353 0.11787736000223 no 3001 0.10900893247736 4275 6256118 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.23289349746556 0.117677675223842 no 3002 0.108807750900712 4314 390807 SGTC_2879 9041815 71.43 µM -1.23566751030491 0.117164740238633 no 3003 0.108291089523872 4329 4942971 SGTC_1361 1608-0041 5.61 µM -1.23694561028604 0.116928944102792 no 3004 0.108053637781784 4285 X1361 SGTC_2525 harmine 47.85 µM -1.23827097714539 0.116684783139915 no 3005 0.107807800727266 4302 5280953 A monoamine oxidase inhibitor SGTC_1106 tegaserod maleate 11.7 µM -1.24025003946763 0.116320870743106 no 3006 0.107441462623634 4336 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2213 7173844 200 µM -1.24234182776108 0.115937106304658 no 3007 0.107055234422318 4314 892728 SGTC_1471 k673-0312 37 µM -1.2463247075665 0.115208884885865 no 3008 0.10632260530512 4269 24099884 SGTC_2967 9089538 49.85 µM -1.24829373073275 0.11485007643604 no 3009 0.105961754620575 4330 728216 SGTC_443 clozapine 122 µM -1.2488936369352 0.114740915712227 no 3010 0.105851989622947 4288 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1132 3456-3614 2.5 µM -1.25018202187164 0.114506726906433 no 3011 0.105616531320578 4354 3125502 SGTC_3128 9127691 49.47 µM -1.25075903905839 0.114401953289892 no 3012 0.105511201639259 4352 41316314 SGTC_2349 9023730 187.07 µM -1.25146744067911 0.114273416507923 no 3013 0.10538199273558 4365 4126287 SGTC_2571 chrysanthemic acid 100 µM -1.25338008938913 0.113926887429647 no 3014 0.105033706997467 4306 2743 An insecticide. SGTC_352 k048-0007 5.11 µM -1.25413601891789 0.11379013659386 no 3015 0.104896285200341 4273 6811911 SGTC_2301 7769476 200 µM -1.26061240549433 0.112623324100943 no 3016 0.103724263443151 4340 977820 SGTC_122 0236-0016 402.397 µM -1.26218775918566 0.112340798521286 no 3017 0.103440616151354 4325 6808838 SGTC_984 1492-0255 2.91 µM -1.26603227154989 0.111653446571317 no 3018 0.102750764331892 4312 1585198 SGTC_2376 9072922 81.32 µM -1.26679055589457 0.111518230569305 no 3019 0.102615094939614 4347 17087968 SGTC_1340 1486-1359 257 µM -1.26863670953306 0.111189517559351 no 3020 0.102285332582492 4271 4309068 SGTC_449 xestospongin c 11.1929 µM -1.26932536162813 0.111067078888414 no 3021 0.102162522238557 4344 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2249 haloperidol 116.36 µM -1.27802287239374 0.109529012698774 no 3022 0.100620680839628 4306 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_156 3474-0145 5.642 µM -1.2799486599111 0.109190534994231 no 3023 0.100281596273789 4267 2265471 SGTC_298 1391-0729 10 µM -1.28116835191285 0.108976550237193 no 3024 0.100067269868533 4289 3237558 SGTC_2131 toluylene red 5.2905 µM -1.28770703076249 0.10783453252206 no 3025 0.0989239826167133 4318 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.28871497818844 0.107659258363747 no 3026 0.0987485966640717 4451 688801 SGTC_1341 1486-1360 280 µM -1.28879818349349 0.107644798789929 no 3027 0.0987341288594035 4338 3976547 SGTC_1645 Cervolide 78 µM -1.29298117413576 0.106919673298417 no 3028 0.0980087851637047 4376 23173 A fragrance. SGTC_1745 st081495 74 µM -1.29674347374093 0.106270490960544 no 3029 0.0973597328672814 4217 13842402 YBL026W LSM2 SGTC_734 2023-0417 80 µM -1.29805859017285 0.106044241323521 no 3030 0.0971336012336868 4372 3935732 SGTC_542 3381-0244 89.3 µM -1.30028081302606 0.105662726443107 no 3031 0.0967523708360017 4379 1112843 SGTC_3292 9120825 59.784 µM -1.30255006253791 0.105274163088259 no 3032 0.096364207977845 4354 24824900 SGTC_3309 9129340 25.759 µM -1.3047249324421 0.104902731573544 no 3033 0.0959932642516115 4378 17158987 SGTC_2805 7950783 58.44 µM -1.3050828682576 0.104841693140755 no 3034 0.0959323158238539 4369 1178958 YDL195W SEC31 SGTC_2156 5649887 115 µM -1.31122667775867 0.10379800172742 no 3035 0.0948905959000562 4394 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_913 3487-1245 167 µM -1.31141717650078 0.103765761291585 no 3036 0.0948584294347085 4324 4016153 SGTC_888 0916-0002 6.97 µM -1.31469891164058 0.103211493169135 no 3037 0.0943055562539189 4413 2802138 YIL048W NEO1 SGTC_24 0417-1663 219 µM -1.31503395827958 0.103155026699074 no 3038 0.094249245003649 4399 4329390 SGTC_2938 9059746 27.26 µM -1.31528907583762 0.103112045977244 no 3039 0.0942063840597943 4380 6471769 SGTC_1276 0871-0068 94.2 µM -1.31598900965519 0.102994191995608 no 3040 0.0940888657416466 4401 3414906 SGTC_3326 9140064 16.379 µM -1.31902443168228 0.102484223717038 no 3041 0.0935804723621404 4326 1868434 SGTC_1115 galangin 695.678 nM -1.32004354407321 0.102313419346842 no 3042 0.0934102400836108 4454 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1043 0916-0009 19.3 µM -1.32443130624776 0.101580390016859 no 3043 0.0926799215519567 4402 3101130 SGTC_2902 5787006 60.46 µM -1.32513505277754 0.101463177340321 no 3044 0.0925631809385279 4339 591003 SGTC_32 0928-0142 34.1 µM -1.32542548279132 0.101414833425286 no 3045 0.0925150348352482 4369 2244242 SGTC_1620 st003704 16.5 µM -1.32608801744862 0.101304613136939 no 3046 0.0924052723430278 4359 2834414 SGTC_114 0364-0001 490.298 µM -1.32674746299773 0.101194993449287 no 3047 0.0922961173447575 4414 4003655 SGTC_343 4130-2827 29.8 µM -1.3270593236161 0.101143182948124 no 3048 0.0922445297354327 4363 1118244 SGTC_916 4466-0038 42 nM -1.32763819701329 0.101047063925117 no 3049 0.0921488297728343 4436 5722064 YGL116W CDC20 SGTC_279 1273-0055 2.93 µM -1.32796787813036 0.100992351796247 no 3050 0.0920943594023867 4419 2847562 SGTC_2276 7947513 42.08 µM -1.33031557064862 0.100603365531705 no 3051 0.0917071595404929 4322 2105100 SGTC_3121 9125696 49.47 µM -1.3337921639136 0.10002934240532 no 3052 0.0911359899049499 4500 1235365 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.33601828839281 0.0996630433501825 no 3053 0.0907716478646027 4347 676296 Flavone; oxidizing agent. SGTC_1964 st076914 61 µM -1.33716845900434 0.0994741722517488 no 3054 0.0905838274706171 4427 24208661 SGTC_1197 1601-0112 267 µM -1.33757557491744 0.0994073819159421 no 3055 0.0905174154907416 4368 7350313 SGTC_2687 chenodiol 100 µM -1.34003613599027 0.0990044066140285 no 3056 0.0901167985187764 4433 5702181 A cholesterol synthesis inhibitor. SGTC_634 1611-4317 11.2 µM -1.34395298769415 0.0983653963866356 no 3057 0.0894817948667379 4423 2843522 SGTC_917 harmaline 728.087 nM -1.34822819796256 0.09767137549119 no 3058 0.088792498920525 4339 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2081 5214970 32.255 µM -1.34844709355501 0.097635937704546 no 3059 0.0887573128903338 4341 2063512 SGTC_564 3555-0129 330 µM -1.3506041556021 0.0972872273597793 no 3060 0.0884111344617299 4292 563260 SGTC_1212 0520-0165 585 µM -1.35245202361549 0.0969892287016024 no 3061 0.0881153783037456 4485 5403258 SGTC_519 k048-0011 62.8 µM -1.3529079570475 0.096915805216937 no 3062 0.0880425185281023 4418 6836379 SGTC_2516 gossypol 71.55 µM -1.35631713196251 0.0963680849600749 no 3063 0.0874991434250958 4420 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1379 2144-0755 36.5 µM -1.35687925800913 0.0962779923195683 no 3064 0.0874097892244832 4452 5392327 SGTC_929 2805-0021 398 µM -1.35762741276243 0.0961581806737868 no 3065 0.0872909700227942 4447 3098024 SGTC_1969 st069479 40.1 µM -1.35835933961584 0.0960410739144412 no 3066 0.0871748448061568 4413 3895485 SGTC_363 0455-0021 3.06 µM -1.36028000897306 0.0957342695677886 no 3067 0.0868706660213502 4354 4597466 SGTC_1450 4112-4260 37.6 µM -1.36387634413326 0.0951617374597011 no 3068 0.0863032435968833 4412 1633175 SGTC_1575 cyproterone acetate 48 µM -1.36484295750198 0.0950082846228281 no 3069 0.0861512069694271 4410 9880 An androgen receptor antagonist and liver toxin. SGTC_1560 lithocholic acid 53.1 µM -1.36600226774404 0.0948244810667275 no 3070 0.0859691258046463 4347 9903 A bile acid which acts as a detergent. SGTC_943 3253-1379 105 µM -1.36639083181698 0.0947629346016131 no 3071 0.085908162443544 4401 668464 SGTC_2905 7799065 20.05 µM -1.36839978956863 0.0944451959830195 no 3072 0.0855934850456857 4294 1296806 SGTC_3310 9130229 44.1445 µM -1.36954026633285 0.0942651670422276 no 3073 0.0854152285119291 4431 7761258 SGTC_827 3253-0474 693 µM -1.37013775403406 0.0941709522519826 no 3074 0.0853219522430382 4425 5402065 SGTC_2435 5706476 10.6 µM -1.37138313672198 0.0939747975306477 no 3075 0.0851277757378833 4404 5725375 SGTC_1081 sertraline 6 µM -1.37576640667068 0.0932868062005369 no 3076 0.0844469825042376 4404 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_997 3996-0078 137 µM -1.37619261001781 0.0932201090099107 no 3077 0.0843810047094417 4461 735687 SGTC_2666 tannic acid 100 µM -1.38095391439311 0.0924773996735483 no 3078 0.0836465655674279 4402 16134267 A thiamine antagonist. SGTC_2965 9082772 38.63 µM -1.38134624120236 0.0924163969509731 no 3079 0.0835862633489683 4428 16459634 SGTC_658 3253-0951 102 µM -1.38227500403306 0.0922721027176167 no 3080 0.0834436389474394 4435 1184878 SGTC_2701 st077767 14.721 µM -1.38364844718099 0.0920590278828731 no 3081 0.0832330630631003 4397 5721188 SGTC_2596 sinensetin 100 µM -1.38376668293983 0.0920407019301462 no 3082 0.0832149538876265 4431 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1700 st030840 7.9285 µM -1.38942271819408 0.0911671969751023 no 3083 0.0823521230066674 4463 5499307 SGTC_2275 7947463 200 µM -1.39121716950443 0.0908913547351134 no 3084 0.0820797911466103 4382 1225414 SGTC_2098 5376439 882.5 nM -1.3928092878895 0.0906471338664556 no 3085 0.0818387345184468 4469 2844116 SGTC_828 2074-0507 139 µM -1.39562897845642 0.0902158069149425 no 3086 0.0814131256762342 4482 X828 SGTC_1697 st025554 27.742 µM -1.39643570639235 0.0900926829885224 no 3087 0.0812916644819443 4434 1269519 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.39969646142969 0.0895962940432154 no 3088 0.0808021169519633 4466 688788 SGTC_481 bay k-8644 50 µM -1.41016409443056 0.0880165368840042 no 3089 0.0792456175997303 4405 2303 A calcium channel antagonist. SGTC_2409 alverine citrate 63.97 µM -1.41160147951563 0.087801241138056 no 3090 0.0790336682644822 4479 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.41331319169791 0.0875453686014688 no 3091 0.078781828469648 4436 688662 SGTC_1997 st073024 93.8 µM -1.41403453739435 0.0874377062192456 no 3092 0.0786758810339806 4486 686268 SGTC_1307 1187-1599 12.2 µM -1.41633256980946 0.0870953788834791 no 3093 0.078339078095732 4447 1538471 SGTC_1149 3909-7961 23.3 µM -1.41723762733513 0.0869608317001311 no 3094 0.0782067320568174 4496 735261 SGTC_1417 3966-0327 90.4 µM -1.4194176538077 0.0866373832663665 no 3095 0.0778886442972436 4520 651118 SGTC_45 0kpi-0036 14.9 µM -1.42042009541661 0.0864889541250376 no 3096 0.0777427079401846 4431 2795021 SGTC_1205 4161-2785 76 µM -1.4218956428547 0.0862708193217084 no 3097 0.0775282741416524 4461 3498106 SGTC_270 tamoxifen 5.46 µM -1.42320255000414 0.086077958984818 no 3098 0.0773387233072653 4467 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1397 3532-0190 20.1 µM -1.42761469058723 0.0854292417885943 no 3099 0.0767013964268855 4403 5322280 SGTC_1794 st048918 76.9 µM -1.43033117566289 0.0850316622656632 no 3100 0.0763109955747031 4422 672303 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.43187523545176 0.0848062956838847 no 3101 0.0760897653651297 4427 688761 SGTC_3021 9087658 49.47 µM -1.43286429698879 0.0846621705788822 no 3102 0.0759483110947647 4459 25237042 SGTC_3263 9137018 49.47 µM -1.43900976904203 0.0837707724292933 no 3103 0.0750738774666947 4412 43844957 SGTC_1540 guanosine 70.6 µM -1.44108468319835 0.0834714044956058 no 3104 0.0747803800862367 4388 6802 Guanosine is a purine nucleoside SGTC_101 0490-5701 117.494 µM -1.44198831004629 0.0833412811203615 no 3105 0.0746528357213116 4333 4661669 SGTC_609 0986-0026 86.3 µM -1.45211229815316 0.0818938229498291 no 3106 0.0732351914710844 4455 2848610 SGTC_1354 1498-1681 81 µM -1.45446665431051 0.0815599446199935 no 3107 0.0729084859728965 4466 5754243 SGTC_2518 prenyletin 46.28 µM -1.45738637645994 0.0811473170298116 no 3108 0.0725048777783744 4487 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1059 3448-6867 171 µM -1.45854874676327 0.0809834850028914 no 3109 0.0723446745175676 4441 3934407 SGTC_1124 fisetin 1.16336 µM -1.46311169975165 0.080342765887346 no 3110 0.0717184084818049 4484 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_3032 9089427 49.47 µM -1.46328187638379 0.0803189443932783 no 3111 0.0716951324079889 4453 17173707 SGTC_1502 4534-4282 27.7 µM -1.46648243058962 0.0798719211923169 no 3112 0.0712584521041584 4454 3278949 SGTC_2541 muurolladie-3-one 83.07 µM -1.46660648800462 0.0798546319794086 no 3113 0.0712415670371116 4429 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.47188654995809 0.079121399210998 no 3114 0.0705257581196956 4473 688669 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.47198876388427 0.079107255418242 no 3115 0.0705119559035869 4484 61125 An anti-inflammatory. SGTC_2838 9002687 71.43 µM -1.47452221486267 0.0787573021516109 no 3116 0.0701705204725037 4463 6457060 SGTC_1469 k284-2957 126 µM -1.47478462704454 0.0787211215112892 no 3117 0.0701352277565758 4476 23884841 SGTC_2303 7774051 200 µM -1.4749330649701 0.0787006608932947 no 3118 0.0701152698772064 4470 2953184 SGTC_2690 usnic acid 100 µM -1.47751486752418 0.0783454306907855 no 3119 0.0697688379665123 4485 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2507 purpurin 79.67 µM -1.47942621489784 0.0780832326026091 no 3120 0.0695132190366458 4475 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2016 5121758 140 µM -1.48048493685259 0.0779382842020953 no 3121 0.069371938854558 4415 2795203 SGTC_3218 9131285 49.47 µM -1.48344232723718 0.0775344730644505 no 3122 0.0689784643276869 4464 17156417 SGTC_2038 4100038 30.985 µM -1.48412037748206 0.0774421142829389 no 3123 0.0688884940532538 4451 3596803 SGTC_2914 7968218 45.32 µM -1.48531843816438 0.077279127965759 no 3124 0.0687297449309037 4445 2977111 SGTC_234 nsc-17383 10.7 µM -1.48608991186936 0.0771743133151781 no 3125 0.0686276701554746 4489 408974 SGTC_2464 5717415 7.67 µM -1.48829072443375 0.0768758981517363 no 3126 0.0683371200304727 4450 5285744 SGTC_2175 5807670 165.306 µM -1.48982425051807 0.0766684816191444 no 3127 0.0681352265005931 4446 241186 SGTC_1761 st044296 37 µM -1.49177512882337 0.0764052316842862 no 3128 0.0678790530474404 4501 1826700 SGTC_2100 5377183 190 µM -1.49299372674881 0.0762411443700298 no 3129 0.0677194145068938 4519 2844202 SGTC_2084 5306078 60.6385 µM -1.49337917215127 0.0761892990347556 no 3130 0.0676689808804931 4432 679340 SGTC_777 1315-0167 517 µM -1.50333670550463 0.0748592171367775 no 3131 0.0663761196894827 4528 4221767 SGTC_421 streptovitacin 30 mM -1.5246666387564 0.072069764666364 no 3132 0.0636711334272929 4504 91467 include heat shock SGTC_329 k048-0121 21.3 µM -1.52601674656087 0.0718959205996804 no 3133 0.0635028469664694 4520 6832902 SGTC_3345 9148410 3.559 µM -1.52613578428208 0.0718806083731354 no 3134 0.0634880259306392 4458 4903596 SGTC_431 k089-0097 107 µM -1.52929663452909 0.071474931698964 no 3135 0.063095461785982 4236 5499420 SGTC_2898 9056270 58.44 µM -1.52935787890263 0.07146708872899 no 3136 0.063087874207328 4531 19154699 SGTC_3087 9117406 49.47 µM -1.53057836489981 0.0713109306717519 no 3137 0.062936816075799 4508 42546093 SGTC_1269 0831-0796 3.05 µM -1.53623826112473 0.0705901831998597 no 3138 0.062239977643445 4545 927758 SGTC_2422 chlorphenesin carbamate 384.24 µM -1.53742007279333 0.0704403969519613 no 3139 0.0620952370029918 4471 2724 A muscle relaxant with antifungal properties. SGTC_1946 st076057 65.1 µM -1.54039279610048 0.0700647057566708 no 3140 0.061732318168179 4508 953009 SGTC_2 0422-0095 29 µM -1.54754136065729 0.0691675855478285 no 3141 0.0608663794879557 4435 6790840 SGTC_590 k048-0076 22.4 µM -1.55041899390945 0.0688089611362608 no 3142 0.0605204912875466 4535 6832814 SGTC_320 4092-0846 5.34 µM -1.55224852882246 0.0685817023123192 no 3143 0.0603013842182951 4489 1359356 SGTC_956 1185-0240 191 µM -1.55627402509252 0.0680837070579312 no 3144 0.0598214726552271 4496 1416193 SGTC_2475 5812728 15.03 µM -1.56015588365148 0.0676061297111581 no 3145 0.0593615240436103 4475 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1938 st074717 56.4 µM -1.56200646529715 0.0673793693454883 no 3146 0.0591432328925791 4388 17250979 SGTC_814 3342-0569 96 µM -1.56254846316386 0.0673130672565674 no 3147 0.059079419179086 4562 4346283 SGTC_1899 st063254 59.6 µM -1.56382831661723 0.0671567041534352 no 3148 0.058928946210854 4485 3093813 SGTC_769 0302-0231 76 µM -1.56418931247203 0.0671126511496551 no 3149 0.0588865581743557 4442 571869 YER009W NTF2 SGTC_1847 st056231 15 µM -1.56978615625801 0.0664325132815434 no 3150 0.058232434659147 4504 5393180 SGTC_517 1365-0151 113 µM -1.56987144961894 0.0664221897265351 no 3151 0.0582225104528683 4525 768657 SGTC_472 calcifediol 10 µM -1.57266372153859 0.0660849101709467 no 3152 0.0578983521833128 4565 5283731 A vitamin D metabolite. SGTC_1829 berberine 14.4 µM -1.58035817632586 0.0651623587046407 no 3153 0.0570124319327752 4502 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1434 4073-0095 163 µM -1.59140277457682 0.0638556378829602 no 3154 0.055759480157007 4547 24133745 SGTC_2976 9009005 19.48 µM -1.59152657331708 0.0638411072332195 no 3155 0.0557455599886685 4517 2993148 SGTC_2895 9054447 58.44 µM -1.59406675104927 0.0635435259504472 no 3156 0.0554605424814093 4601 2697450 SGTC_592 k241-0073 46.5 µM -1.59469950360511 0.0634695673164271 no 3157 0.055389724555968 4583 4230158 SGTC_923 1900-2434 73.3 µM -1.5970097621872 0.0632001038568543 no 3158 0.0551317655853522 4520 5910570 SGTC_3085 9117376 49.47 µM -1.59752170995819 0.0631405121449632 no 3159 0.0550747311520788 4603 16480349 SGTC_1392 3455-1037 33.9 µM -1.59910108106759 0.062956945990644 no 3160 0.0548990722629263 4554 981132 SGTC_3286 9117135 37.221 µM -1.59980589020682 0.0628751621537303 no 3161 0.0548208258635227 4492 3438150 SGTC_1447 4239-0816 81.9 µM -1.60334392683872 0.0624658695516705 no 3162 0.054429371704569 4562 1341554 SGTC_1127 asiatic acid 681.4 nM -1.60409979970732 0.062378697407125 no 3163 0.0543460280233878 4494 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_158 k038-0087 26.446 µM -1.61021290062228 0.0616771769668664 no 3164 0.0536756930130921 4460 X158 SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.61110307351642 0.0615755393153307 no 3165 0.0535786292949688 4580 77254 SGTC_5 0352-0601 109.883 µM -1.61462125849138 0.0611751215126523 no 3166 0.053196369444996 4456 762456 SGTC_2238 6671620 73.2395 µM -1.62002185437237 0.0605644222577606 no 3167 0.0526137912034438 4473 729941 SGTC_3147 9097027 49.47 µM -1.62325232825789 0.060201406450056 no 3168 0.0522677378836215 4559 25236841 SGTC_53 0973-0023 39.979 µM -1.6242804880597 0.0600862277793813 no 3169 0.0521579797951914 4477 674768 SGTC_2815 7968870 71.43 µM -1.62874641329777 0.0595879378098889 no 3170 0.0516833564539459 4482 2977326 YHR190W ERG9 SGTC_3100 9120536 49.47 µM -1.63087142222808 0.0593519777417833 no 3171 0.0514587264755355 4455 16421196 SGTC_725 1497-0963 19 µM -1.63511691967858 0.0588827538793613 no 3172 0.0510122699563117 4613 3549977 SGTC_2010 4012422 159 µM -1.63853017994619 0.0585076260743488 no 3173 0.0506555718373019 4513 952393 SGTC_3042 9091578 49.47 µM -1.63855165459084 0.0585052718990616 no 3174 0.050653333963502 4552 25236497 SGTC_1720 st037298 9.481 µM -1.64542196888693 0.0577559189041161 no 3175 0.0499414110835667 4545 597396 SGTC_1892 st058411 7.36 µM -1.65588482273263 0.0566292454148925 no 3176 0.0488725728746909 4564 3934738 SGTC_257 daunorubicin 18.5 µM -1.66375126044841 0.0557936221895495 no 3177 0.0480810738681188 4597 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_121 0557-0495 61.343 µM -1.66497991574515 0.0556639895712504 no 3178 0.0479583814241634 4599 3104427 SGTC_1619 st003326 88.7 µM -1.66586212589063 0.0555710562965866 no 3179 0.0478704393610598 4558 2849032 SGTC_1797 st048695 56.8 µM -1.66727910226218 0.0554220463680485 no 3180 0.0477294600183257 4533 592262 YIL048W NEO1 SGTC_2285 7945142 200 µM -1.67106614642739 0.0550253470252277 no 3181 0.0473543066219389 4580 2970608 SGTC_683 panaxydol 45 µM -1.67365042368589 0.0547559298811897 no 3182 0.047099661217315 4596 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2094 5332512 191.667 µM -1.6832457976734 0.0537647029253413 no 3183 0.0461637591959997 4599 755774 SGTC_710 3448-4187 58 µM -1.6869400135244 0.0533868908752908 no 3184 0.0458074435249135 4546 3946412 SGTC_515 4092-1064 102 µM -1.68887507240729 0.053189831378389 no 3185 0.0456216866203993 4551 717353 SGTC_2125 5246583 200 µM -1.69027793408518 0.0530473298481694 no 3186 0.0454873972806849 4591 835267 SGTC_699 0375-0592 111 µM -1.69265900186088 0.0528061561173672 no 3187 0.0452601966577432 4647 762578 SGTC_178 4092-0806 87.505 µM -1.69322740531447 0.0527487124405762 no 3188 0.0452060950112939 4478 2169044 SGTC_1251 0490-5699 265 µM -1.69480934422942 0.0525891003850312 no 3189 0.045055797149598 4600 3883818 SGTC_417 st075190 100 µM -1.6949296731 0.0525769753303069 no 3190 0.0450443813454441 4578 222757 SGTC_511 blebbistatin 171 µM -1.69512750017417 0.0525570459168558 no 3191 0.0450256182149297 4625 3476986 A myosin inhibitor. SGTC_3112 9123419 49.47 µM -1.70505582362472 0.0515645292098527 no 3192 0.044092006800565 4629 17015854 SGTC_1189 1431-2119 7.28 µM -1.71028876491009 0.0510474314686341 no 3193 0.0436062441617872 4594 3107275 SGTC_54 0159-0055 9 µM -1.71245972285824 0.0508341212641214 no 3194 0.0434059905255764 4568 3319099 SGTC_1391 3442-0225 151 µM -1.71933571927149 0.0501631920612415 no 3195 0.0427766297594702 4596 5227075 SGTC_2352 9027995 87.8 µM -1.72464444464932 0.0496500346809836 no 3196 0.0422957843151325 4561 2997347 SGTC_3329 9141233 27.5565 µM -1.72611375468387 0.0495087493133371 no 3197 0.0421634748870911 4564 4909101 YNL103W MET4 SGTC_418 lividomycin a 100 µM -1.72989567673057 0.0491465643509748 no 3198 0.0418244579259634 4617 72394 An antibiotic. SGTC_165 k038-0023 64.381 µM -1.73072835733601 0.0490671056185014 no 3199 0.0417501125239859 4560 46368543 SGTC_2164 5685496 200 µM -1.73123583883472 0.0490187294339714 no 3200 0.0417048548507163 4547 759046 SGTC_588 3970-1144 52.9 µM -1.73137819449905 0.0490051660823682 no 3201 0.0416921665789988 4519 1888707 SGTC_187 1488-2104 32.728 µM -1.73367440652545 0.0487868017213424 no 3202 0.0414879350462481 4593 2852859 SGTC_1427 4048-4900 550 nM -1.73434087552571 0.0487235679074098 no 3203 0.0414288094529337 4586 24132586 SGTC_3193 9111931 49.47 µM -1.73727191123869 0.0484462517983917 no 3204 0.0411695935296729 4592 17087244 SGTC_2909 7941780 10.49 µM -1.74113442708083 0.048082734234936 no 3205 0.0408300089940397 4563 1243215 SGTC_3054 9094397 49.47 µM -1.74934522809094 0.0473172337739958 no 3206 0.0401156812025818 4584 2598354 SGTC_1312 1218-2183 165 µM -1.7572736789633 0.0465873561457901 no 3207 0.0394355859779721 4659 6744073 SGTC_3262 9137218 49.47 µM -1.76859612756352 0.0455607277344345 no 3208 0.0384806487335881 4629 17650664 SGTC_1275 0867-0008 21.1 µM -1.77074388112046 0.0453680546662303 no 3209 0.0383016509126878 4601 3422836 SGTC_1888 azatryptophan 97.5 µM -1.78339620450197 0.0442462909512304 no 3210 0.0372609153273387 4632 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2993 9054257 71.4286 µM -1.78389291024889 0.044202712894534 no 3211 0.0372205340870462 4542 6470217 YGL055W OLE1 SGTC_99 0109-0120 622.8 µM -1.78588853223855 0.0440279773212475 no 3212 0.037058654067441 4625 759414 SGTC_466 geldanamycin 89.2 µM -1.79200414653361 0.0434959639958499 no 3213 0.0365661508993536 4661 5288382 HSP90 inhibitor. SGTC_643 k048-0106 28.4 µM -1.8048746625291 0.0423932748720849 no 3214 0.0355471487573295 4653 6763920 SGTC_3157 9099274 49.47 µM -1.80551874130531 0.0423386926578627 no 3215 0.0354967727517741 4628 17217662 SGTC_2000 st075254 36.4 µM -1.80692872139123 0.042219402871409 no 3216 0.0353866968184957 4537 17234175 SGTC_2093 5331342 194.4 µM -1.81310440416017 0.0417001166255657 no 3217 0.0349078600180935 4651 33839 SGTC_3230 9131665 49.47 µM -1.81796366573862 0.0412951694632419 no 3218 0.0345348431741669 4652 15943720 SGTC_1903 st060211 78.3 µM -1.8225463520049 0.0409161970374561 no 3219 0.034186063656305 4653 688960 SGTC_2970 9090938 41.86 µM -1.82645102201429 0.0405955246435252 no 3220 0.0338911762025593 4653 17217104 SGTC_1445 4239-0156 97.7 µM -1.8303550346323 0.0402769486884176 no 3221 0.0335984334290345 4666 4008346 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.83051820384723 0.0402636780569118 no 3222 0.0335862436215358 4592 4000243 SGTC_2628 lathosterol 100 µM -1.83245516812698 0.040106414956999 no 3223 0.0334418176141794 4656 6710616 SGTC_3306 9127676 59.7925 µM -1.8346865142577 0.0399258698157 no 3224 0.0332760757951833 4581 41905287 SGTC_971 1315-0384 26.7 µM -1.84163618385584 0.0393677792410856 no 3225 0.0327641922855077 4660 6769120 SGTC_1024 4507-0395 26 µM -1.84401868798996 0.0391779204327354 no 3226 0.0325902083578921 4659 4201836 SGTC_571 k831-0106 44.2 µM -1.8483552917548 0.0388342549835593 no 3227 0.0322754809377622 4547 4783639 SGTC_2928 9011484 9.79 µM -1.85281295017374 0.0384835594094772 no 3228 0.0319545867072502 4618 2994751 SGTC_2462 5162487 171.77 µM -1.86676596011473 0.0374024928298022 no 3229 0.0309671390067338 4638 2259986 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.87064906050446 0.0371060858049315 no 3230 0.0306968698508777 4647 689007 SGTC_1153 4055-0057 267 µM -1.87230412805048 0.0369803350841329 no 3231 0.0305822699967696 4680 882706 SGTC_501 nsc-95397 161 µM -1.87861670633118 0.0365039049642519 no 3232 0.0301484241701968 4645 262093 SGTC_1875 nocodazole 6 µM -1.88125970252249 0.0363059269753411 no 3233 0.0299682999271896 4676 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1490 4089-0339 670 nM -1.88177341613988 0.0362675486133709 no 3234 0.0299333933538687 4666 742542 SGTC_1301 naphtanilide LB 4.81 µM -1.88209346171006 0.0362436555404126 no 3235 0.0299116634768262 4689 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2163 5671233 125 µM -1.88258496185557 0.0362069875804143 no 3236 0.029878317962047 4597 701023 SGTC_2926 9010726 65.15 µM -1.88656313577663 0.0359113157126926 no 3237 0.0296095545036862 4640 2994293 SGTC_2006 4011487 200 µM -1.8989611024386 0.035002520271165 no 3238 0.0287847952366681 4594 45595294 SGTC_2240 6690706 185.951 µM -1.90855813419473 0.0343120729889487 no 3239 0.0281595585146766 4579 805876 SGTC_1983 st071813 46.9 µM -1.9186904239129 0.0335953047267929 no 3240 0.0275117620702819 4698 11838595 SGTC_2250 alverine citrate 130 µM -1.92316626384724 0.0332826272447659 no 3241 0.0272295863019005 4529 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_661 1304-0007 33.6 µM -1.92984892306917 0.0328202477434585 no 3242 0.0268127798238485 4694 3117130 SGTC_1375 2910-0797 186 µM -1.93005570170816 0.0328060254264042 no 3243 0.0267999682066644 4671 742508 SGTC_1009 4106-0057 9.87 µM -1.94430170684732 0.0318383439670867 no 3244 0.0259295394773557 4662 2928005 SGTC_2927 9011802 47.9 µM -1.9500683984925 0.0314533949042342 no 3245 0.0255839836054089 4631 43912568 SGTC_1281 0884-0031 11.8 µM -1.95129995158115 0.0313716845600784 no 3246 0.0255106874179817 4681 1548255 SGTC_1861 st057647 17.4 µM -1.95809256436175 0.0309241602075754 no 3247 0.0251095760540943 4673 688668 SGTC_2340 7987427 183.45 µM -1.96379646881035 0.0305524574503939 no 3248 0.0247768498853415 4642 2239331 SGTC_3004 9076122 71.4286 µM -1.97562043825102 0.0297937130541919 no 3249 0.0240988910273872 4666 44782551 SGTC_1728 st035614 33.7865 µM -1.97805631819492 0.0296393605381373 no 3250 0.0239611768247354 4633 15945546 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.97956488631658 0.0295441014560016 no 3251 0.0238762209280259 4660 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2308 7584454 197.62 µM -1.98288104653881 0.0293355944204995 no 3252 0.0236903591220736 4650 893577 SGTC_789 1309-1135 70.6 µM -1.98514629966728 0.0291938678977485 no 3253 0.0235640984298763 4663 3092424 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -2.00284027615518 0.0281062964480427 no 3254 0.0225972176293746 4680 803109 SGTC_1930 st074634 34.3 µM -2.01734357134882 0.0272401938124916 no 3255 0.0218298357990738 4623 684253 YOR116C RPO31 SGTC_2603 homopterocarpin 100 µM -2.01765509958468 0.0272218371187213 no 3256 0.0218135970602377 4660 101795 A weak amylase inhibitor. SGTC_1388 3346-4487 254 µM -2.02428937152925 0.0268333583687388 no 3257 0.0214701932837006 4701 3345614 SGTC_728 3030-5151 22.5 µM -2.02633672656681 0.0267144115009649 no 3258 0.0213651450567795 4726 3125388 SGTC_1562 morin hydrate 59.1 µM -2.02708783950029 0.0266708840314814 no 3259 0.0213267151407837 4689 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_655 k060-0012 42 µM -2.02843487724232 0.0265929707225856 no 3260 0.021257941755097 4709 5994525 SGTC_2656 pseudo-anisatin 100 µM -2.03192685061922 0.0263918782429896 no 3261 0.0210805309146107 4745 6708809 A neurotoxin. SGTC_1331 1472-0049 76.2 µM -2.03222236093688 0.0263749191540656 no 3262 0.0210655750780559 4687 24051409 SGTC_2520 obtusaquinone 4.71 µM -2.03393095297722 0.0262770429729501 no 3263 0.0209792788022148 4698 5967872 SGTC_1282 0886-0010 32.4 µM -2.03646546744183 0.0261324134908541 no 3264 0.0208518186485672 4699 2836211 YNL267W PIK1 SGTC_1186 1319-0216 26 µM -2.03688506607538 0.0261085338680461 no 3265 0.0208307805073506 4715 4565136 SGTC_2226 7298446 200 µM -2.03932504337329 0.0259700345454173 no 3266 0.0207087989143615 4706 3283010 SGTC_3149 9097855 49.47 µM -2.04966511510952 0.0253899087792918 no 3267 0.0201985607252007 4668 25236625 YMR079W SEC14 SGTC_112 phenothiazine 287.218 µM -2.06368910391661 0.0246204776353249 no 3268 0.0195236015576052 4681 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2655 perillic acid 100 µM -2.07059360037051 0.0242489064278431 no 3269 0.0191983953644433 4729 5702197 An apoptosis inducer. SGTC_193 1273-0060 1.558 µM -2.0814794401471 0.0236726474911948 no 3270 0.0186950220284495 4603 2847393 YHR072W ERG7 SGTC_1710 st031758 61.5 µM -2.0878257272495 0.0233420420956925 no 3271 0.0184067789643691 4716 5394341 SGTC_312 4092-0653 6.84 µM -2.10952490556049 0.0222408506827707 no 3272 0.0174496492866804 4605 1148278 SGTC_606 k015-0008 38.6 µM -2.1210783653927 0.021672636864921 no 3273 0.0169576041221614 4734 1970475 SGTC_435 c-PAF 6.7 µM -2.12183992422427 0.0216356172637204 no 3274 0.0169255913636547 4627 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2843 9000894 45.46 µM -2.13247722319216 0.0211240954985254 no 3275 0.0164838174868006 4735 2242070 SGTC_2748 diazoxide 86.69 µM -2.1753201304957 0.019166252974476 no 3276 0.0148030675143081 4771 3019 A potassium channel activatior. SGTC_1712 st032288 53.4 µM -2.19113928408987 0.0184834247327917 no 3277 0.0142208573445362 4537 2883011 SGTC_2598 perillyl alcohol 100 µM -2.19916935682914 0.0181448098700499 no 3278 0.0139329411787704 4699 10819 An apoptosis inducer. SGTC_425 3825-7017 13.1 µM -2.2095231125351 0.0177160248170849 no 3279 0.0135691383120423 4708 3397440 SGTC_3266 9136860 49.47 µM -2.21055100837052 0.0176739317482297 no 3280 0.0135334722766276 4504 4871271 YPR165W RHO1 SGTC_1491 4138-0063 26.5 µM -2.21895006125779 0.0173331715175599 no 3281 0.0132450610862005 4759 23883227 SGTC_1230 0170-0365 3.77 µM -2.24153826484515 0.0164444552884916 no 3282 0.0124956148978751 4730 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2078 5212016 200 µM -2.24579176359745 0.0162815437860355 no 3283 0.0123586745630304 4681 1899708 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -2.247508456003 0.0162161860778289 no 3284 0.0123037753889538 4716 5377381 SGTC_1351 1496-0003 46.5 µM -2.25482680422067 0.0159400782621532 no 3285 0.0120721010618325 4748 3891978 SGTC_1976 st070609 63.5 µM -2.26674500008791 0.0154990532522885 no 3286 0.011702903859005 4718 682556 SGTC_2745 rifampicin 24.3 µM -2.27040848757397 0.0153656103911372 no 3287 0.0115914049950654 4790 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1113 artemisinin 1.17947 µM -2.27236638903437 0.0152946990217964 no 3288 0.0115321950109162 4746 2240 An anti-malaria and mitochondrial poison. SGTC_1039 k821-0043 94 µM -2.2745359988331 0.0152164484522667 no 3289 0.0114668896106032 4702 15992768 SGTC_3222 9128301 49.47 µM -2.29549190076796 0.0144781784382801 no 3290 0.0108524750195463 4696 4911358 SGTC_1237 0330-0133 46.1 µM -2.30624746712097 0.0141113849931827 no 3291 0.0105484043279151 4714 X1237 YHR072W ERG7 SGTC_2201 6605497 169.863 µM -2.31335513309251 0.0138734131442471 no 3292 0.0103515608737386 4737 670741 SGTC_611 3453-1652 23.7 µM -2.32481043031199 0.0134971609946428 no 3293 0.0100410495184222 4730 1560575 SGTC_2223 6903751 107.57 µM -2.32894586132685 0.0133635125587727 no 3294 0.00993096697299037 4722 5598863 SGTC_314 1671-0008 2.74 µM -2.33348256857723 0.0132182118141028 no 3295 0.00981141607989027 4635 3913060 SGTC_468 gf-109203x 121 µM -2.34403740659593 0.0128854357620764 no 3296 0.00953812903514816 4775 2396 A protein kinase C inhibitor. SGTC_846 0335-0850 148 µM -2.35435559821589 0.0125671492792869 no 3297 0.00927742567717527 4744 6819598 SGTC_128 0906-2981 13.371 µM -2.3640572579708 0.012274112022705 no 3298 0.00903800931287817 4738 6740226 SGTC_1489 4065-0444 182 µM -2.3640767212567 0.0122735301387964 no 3299 0.00903753449073586 4751 2877968 SGTC_2724 maprotiline 69.64 µM -2.36424303309553 0.0122685589734086 no 3300 0.00903347807369034 4707 4011 A tricyclic antidepressant. SGTC_1117 retinoic acid 1.10837 µM -2.36754363651222 0.01217026212102 no 3301 0.00895330413547953 4773 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1058 3448-5425 97.3 µM -2.39647951932186 0.0113373429402996 no 3302 0.00827670927549751 4728 7279705 SGTC_2646 retinol 96.75 µM -2.4134605671572 0.0108719784734529 no 3303 0.00790091883224686 4769 445354 A vitamin A analog and teratogen. SGTC_370 0180-0345 38.7 µM -2.42276081904832 0.0106242209852636 no 3304 0.00770153215567527 4655 3989527 SGTC_1979 st071809 45.3 µM -2.42677856513771 0.0105187191311689 no 3305 0.00761677526329518 4769 4976333 SGTC_1411 3909-8223 150 µM -2.42793975973613 0.0104883979080687 no 3306 0.00759243261051012 4783 X1411 SGTC_3108 9121785 49.47 µM -2.43032961272262 0.0104262334446942 no 3307 0.00754254852110985 4678 17140271 SGTC_1618 st003135 44.5 µM -2.4351405120083 0.0103020664024486 no 3308 0.00744300394198863 4747 1270615 SGTC_2002 4023503 131 µM -2.43643885641356 0.0102687784830122 no 3309 0.00741633842271542 4737 4736863 YCR052W RSC6 SGTC_2129 girgensonine 121.053 µM -2.43917323393679 0.0101989791367422 no 3310 0.00736045471173166 4732 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2762 leflunomide 42.06 µM -2.44965516179165 0.00993523091235707 no 3311 0.00714965430338215 4741 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1993 st073995 70.8 µM -2.4550205281707 0.0098025452981474 no 3312 0.00704382716730342 4752 3098394 SGTC_3219 9131112 49.47 µM -2.45664576896785 0.00976265969044252 no 3313 0.00701204469156888 4645 17612988 YMR079W SEC14 SGTC_1040 k898-0338 155 µM -2.4568113500788 0.00975860407472882 no 3314 0.00700881377767637 4739 20969351 SGTC_2336 9001819 198.65 µM -2.46259301445573 0.00961791234070216 no 3315 0.00689681947929731 4724 2989602 SGTC_1982 st072467 71.9 µM -2.46264200021587 0.00961672792884395 no 3316 0.00689587738638848 4749 3163533 SGTC_3265 9137266 49.47 µM -2.46849016961762 0.00947623973203257 no 3317 0.00678421894139406 4748 17224265 SGTC_1928 4'-methoxychalcone 40.3 µM -2.47337484852321 0.00936027591205761 no 3318 0.0066921836926708 4749 641818 SGTC_2896 9052656 71.43 µM -2.48050060495949 0.00919333502287284 no 3319 0.00655990205793797 4431 6469436 SGTC_33 0986-0033 35.816 µM -2.50049507297788 0.0087387474580006 no 3320 0.00620099290616583 4754 2848082 SGTC_1830 st055982 50.3 µM -2.5045179513448 0.00864970419853137 no 3321 0.00613091913711272 4744 455313 An antimicrobial agent. SGTC_2166 5933061 31.504 µM -2.51297269862827 0.00846515480115691 no 3322 0.00598592996675099 4713 2877375 SGTC_367 0335-0881 7.1 µM -2.57584081277044 0.00719797465179755 no 3323 0.00499983358208096 4709 23828853 SGTC_2517 totarol 10 µM -2.58639702386596 0.00700246015329289 no 3324 0.00484925726947135 4769 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1880 MG-132 525 µM -2.59617805901712 0.00682550227831345 no 3325 0.00471335999213396 4746 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_723 4182-0001 115 µM -2.64446016744139 0.00600861600552163 no 3326 0.00409106681402146 4757 744821 YLR208W SEC13 SGTC_2982 9019404 25.97 µM -2.65914552626987 0.00577796714515526 no 3327 0.00391695585740961 4744 22333232 SGTC_133 0724-0033 378.92 µM -2.67632221084372 0.00551818538492725 no 3328 0.00372175230776827 4747 280309 SGTC_1897 st060201 15 µM -2.68585948011498 0.00537846911559927 no 3329 0.00361717533909651 4781 611878 SGTC_794 k038-0031 316 µM -2.72885019094858 0.0047869566075395 no 3330 0.00317777845988163 4771 6624242 SGTC_97 0535-0701 19.132 µM -2.7424329679977 0.00461252150883881 no 3331 0.00304929479722927 4739 2832013 YGL099W LSG1 SGTC_2998 9066762 71.4286 µM -2.74710030122214 0.00455390471134636 no 3332 0.00300623720380212 4755 4945196 SGTC_2021 4019055 173 µM -2.76713914343053 0.00430972469504754 no 3333 0.00282753064647169 4664 44827708 YER133W GLC7 SGTC_2490 carminic acid 95.39 µM -2.77375646786968 0.00423170003413825 no 3334 0.00277065714505008 4766 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2746 daunorubicin 9.88 µM -2.81411304923811 0.00378261246334789 no 3335 0.00244560120278815 4794 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3018 9082602 49.47 µM -2.82573955818476 0.003661414601041 no 3336 0.00235858002892964 4705 17332089 SGTC_2768 sulfasalazine 50.2 µM -2.84468628030593 0.00347135945094178 no 3337 0.00222275916899613 4767 5384001 An antioxidant and salicylic acid derivative. SGTC_39 0986-0283 58.349 µM -2.88070223599676 0.00313434451175448 no 3338 0.00198395152044378 4787 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_3009 9080819 71.4286 µM -2.93142160808639 0.00270964383307293 no 3339 0.00168707256164438 4795 17027216 SGTC_40 0327-0103 19.753 µM -2.9818438551031 0.00233963702766797 no 3340 0.00143259045262044 4710 409036 SGTC_1155 4088-0394 48.2 µM -3.01205556434939 0.00214048644431602 no 3341 0.00129742547924404 4794 2326248 SGTC_649 1123-0311 367 µM -3.01531668309249 0.00211993585323928 no 3342 0.00128355533532864 4750 693629 YIL048W NEO1 SGTC_2777 climbazole 1.536 µM -3.01944838997721 0.00209415611671572 no 3343 0.00126617717202577 4667 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1131 3454-3128 32.3 µM -3.0872077917643 0.00171002726035169 no 3344 0.00101023153667496 4774 710982 SGTC_1160 4092-0570 10.5 µM -3.19182339754467 0.00124144728755428 no 3345 0.000706888724863256 4787 4994975 SGTC_2085 5307070 144.047 µM -3.23324283864815 0.00109091269588412 no 3346 0.000611967372267313 4784 2840351 SGTC_2761 levamisole 97.89 µM -3.33047232763698 0.00080094989904541 yes 3347 0.000433493903336904 4795 26879 An alkaline phosphatase inhibitor. SGTC_364 0083-0097 67.7 µM -3.54092221800714 0.000399561168838799 yes 3348 0.00019936555281506 4795 5207356 SGTC_2586 curcumin 80 µM -3.59531150245818 0.000331850395812452 yes 3349 0.000162001828504444 4782 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1923 st058458 19.1 µM -3.60337500156823 0.000322772326148158 yes 3350 0.000157055919325249 4802 3534982 SGTC_2088 5278280 127.392 µM -3.60861007775968 0.000317002792535873 yes 3351 0.000153920945725967 4802 791502 SGTC_2335 9018011 154.17 µM -3.63304879641544 0.000291316468337825 yes 3352 0.000140046011907828 4803 6458208 SGTC_2585 alliin 100 µM -3.63869027010618 0.000285668945689779 yes 3353 0.00013701406595339 4799 87310 A garlic compound which reacts with lipids. SGTC_2288 7946289 167.31 µM -3.81168768660786 0.000154728795656269 yes 3354 6.90105984875548e-05 4805 1246052 SGTC_3152 9099253 49.47 µM -4.60678950444368 6.69688874152105e-06 yes 3355 2.04466792597744e-06 4773 25236131 SGTC_2981 9013952 38.96 µM -5.91681128800837 1.18054368963234e-08 yes 3356 1.641214663804e-09 4809 2996344