SGTCid condition conc unit APC4|YDR118W.score APC4|YDR118W.strain.pval APC4|YDR118W.strain.significant APC4|YDR118W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2567 aureobasidin a 60 nM 7.93165617314788 1.39376210169986e-17 yes 1 1.08121218233345e-15 17 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_367 0335-0881 7.1 µM 5.7036908767049 6.11329860440413e-10 yes 2 5.86203069326145e-09 9 23828853
SGTC_45 0kpi-0036 14.9 µM 5.08927842404217 2.95531189571986e-08 yes 3 1.79714280478474e-07 4 2795021
SGTC_2482 5981709 142.65 µM 5.05740621530078 3.57287756409173e-08 yes 4 2.12498659232806e-07 8 877755
SGTC_2458 5808907 16.39 µM 4.3372076755579 1.92980317360291e-06 yes 5 7.21521328096026e-06 2 2731747
SGTC_266 formosanin C 406 nM 4.24845017566517 3.033050101627e-06 yes 6 1.07627253482984e-05 22 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2582 agaric acid 100 µM 4.05246678978465 7.98375358009247e-06 yes 7 2.53402099573352e-05 31 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1063 disulfiram 1.84 µM 3.88018532296309 1.80574681267603e-05 yes 8 5.21884526798372e-05 9 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2583 asiatic acid 100 µM 3.87724415473878 1.83056872742693e-05 yes 9 5.28231637779848e-05 11 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2471 5466956 24.79 µM 3.82862692797462 2.29088110801041e-05 yes 10 6.44300843992729e-05 20 724419
SGTC_278 4092-0821 23.9 µM 3.61471647970195 5.9618069411064e-05 yes 11 0.00015033824338902 4 877900
SGTC_332 4112-0506 40.9 µM 3.60327814934588 6.26588163728412e-05 yes 12 0.000157114477569177 28 2790355
SGTC_840 0245-0196 390 µM 3.53338017328477 8.46578128582646e-05 yes 13 0.000205141013739569 4 3827528
SGTC_67 0335-0847 266 µM 3.5305172276125 8.56980308632051e-05 yes 14 0.000207374002419544 27 4552207 YOR254C SEC63
SGTC_1204 4049-0315 18.3 µM 3.52587095544797 8.74118246959935e-05 yes 15 0.000211046292555003 13 588402
SGTC_820 1582-0060 59.9 µM 3.44874040557863 0.000121016502393065 yes 16 0.000281603935534999 14 3848840
SGTC_2415 st077333 57.7 µM 3.3836844804965 0.000158429501759458 yes 17 0.000357600707661703 22 2766255
SGTC_1215 3852-0577 11.2 µM 3.34585877027304 0.000184904981162834 yes 18 0.000410140821576289 13 2884876
SGTC_1746 st038117 42 µM 3.33397099846166 0.000194045012284936 yes 19 0.000428077920183434 9 2898218
SGTC_2308 7584454 197.62 µM 3.31278524309874 0.000211388682548052 yes 20 0.000461859394671549 20 893577
SGTC_1906 st060206 94.7 µM 3.31188302813501 0.00021215847853287 yes 21 0.000463351422125913 5 5133468
SGTC_541 4513-1321 94 µM 3.23341443175481 0.000290074070305806 yes 22 0.000611599867702056 17 747515
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 3.22779278525476 0.000296572709972371 yes 23 0.000623746523960969 20 16725076
SGTC_2459 5811157 9.22 µM 3.16446531183058 0.000379759952535087 yes 24 0.000776840906157817 14 2870684 YBR192W RIM2
SGTC_2110 5483698 200 µM 3.0989990636717 0.000488150325038147 yes 25 0.000970878168849874 15 2848765 YHR062C RPP1
SGTC_453 enantio-paf c16 10 µM 3.09079207012723 0.000503597148404819 yes 26 0.000998116853628631 35 13871343 A lipid and platelet activating factor
SGTC_2519 cryptotanshinone 88.04 µM 3.05137603521135 0.000584288676536585 yes 27 0.00113897545136812 34 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_542 3381-0244 89.3 µM 3.03521198062684 0.000620709076961958 yes 28 0.00120183340008549 15 1112843
SGTC_1282 0886-0010 32.4 µM 3.02969429460942 0.000633613751539953 yes 29 0.00122400694037335 27 2836211 YNL267W PIK1
SGTC_3048 9093155 49.47 µM 3.02654631838544 0.000641086705921949 yes 30 0.0012368245964507 5 25236002
SGTC_783 0848-0141 92.7 µM 3.01623640923107 0.000666134604622025 yes 31 0.00127966815666899 32 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_969 1313-0238 134 µM 3.00673108982556 0.00069002468587971 yes 32 0.00132036626100501 42 5212874
SGTC_2317 5986382 200 µM 3.00417006845777 0.000696595190128745 yes 33 0.00133153209410804 13 877883
SGTC_137 0438-0332 85.389 µM 2.9753154744483 0.00077471743692611 yes 34 0.00146343688940031 66 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2093 5331342 194.4 µM 2.95533954502966 0.000833443640165453 yes 35 0.00156162554772256 17 33839
SGTC_2076 5212012 200 µM 2.92684954993611 0.000924305041346439 yes 36 0.00171207239582896 8 604802
SGTC_455 paf C-16 10 µM 2.89866732845242 0.00102305829394747 no 37 0.00187376141746535 19 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1882 5615643 20 µM 2.83860185920284 0.00126659689941816 no 38 0.00226558274260173 18 2253075
SGTC_2107 5363541 170.161 µM 2.80298866515734 0.00143495828209528 no 39 0.00253157243800951 24 244052
SGTC_3064 1327-0027 10 µM 2.72006537461297 0.00190891159312594 no 40 0.00326345055040474 15 16000455 YPR107C YTH1
SGTC_1183 1254-0324 198 µM 2.67620614806023 0.00221344405666806 no 41 0.00372304147670131 13 5799357
SGTC_2541 muurolladie-3-one 83.07 µM 2.65928049498957 0.00234228905755779 no 42 0.00391538692154052 51 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_821 1114-0266 29.2 µM 2.65751741879897 0.00235609348245315 no 43 0.00393592611924327 20 3123235
SGTC_2754 granisetron 64.02 µM 2.63805875022185 0.00251341582821428 no 44 0.00416910674190758 21 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_280 3448-3607 3.04 µM 2.62530262858377 0.00262163965238679 no 45 0.00432859919110864 13 626179
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 2.612527423682 0.0027342272998323 no 46 0.00449377407318626 29 551469
SGTC_1997 st073024 93.8 µM 2.59553763746689 0.00289071635601827 no 47 0.00472215293288774 16 686268
SGTC_1255 0566-0045 221 µM 2.56914601258549 0.00314985949534575 no 48 0.00509747455316738 36 2788469
SGTC_1283 0922-0125 16.4 µM 2.56370941391942 0.00320577123569488 no 49 0.0051780103399684 14 3360884
SGTC_186 3455-3465 67.277 µM 2.50090697704131 0.00391948703697431 no 50 0.00619378557185241 21 755278
SGTC_553 k007-0256 45.7 µM 2.48993417442094 0.00405786686461514 no 51 0.0063883378221276 40 6287000
SGTC_1006 4099-6547 255 µM 2.48979629019526 0.00405963322324624 no 52 0.00639081658953158 30 3146833
SGTC_2514 salinomycin 42.74 µM 2.4841046889096 0.00413314841069112 no 53 0.00649388098638225 30 23682228 A polyether potassium ionophore.
SGTC_804 1595-0054 20.9 µM 2.47861176954574 0.00420522454077693 no 54 0.00659473900511831 26 761523 Stimulates phospholipase C.
SGTC_1026 k007-1105 30.6 µM 2.45695944847612 0.00450041126537284 no 55 0.00700592510984334 46 7066794
SGTC_365 0121-0052 13.6 µM 2.45660713897726 0.0045053635962365 no 56 0.00701279865126415 32 3101739
SGTC_159 3970-0959 50 µM 2.4343629989611 0.00482806892074098 no 57 0.00745901298835549 56 6615653
SGTC_2292 7671323 168.05 µM 2.41182998214784 0.00517581756667958 no 58 0.00793634063477108 43 937504
SGTC_922 1866-0035 480 µM 2.40719783678591 0.0052500072263131 no 59 0.00803772942390154 41 3156169
SGTC_730 1436-0052 41.2 µM 2.40655218458661 0.00526042293302552 no 60 0.00805195154902256 37 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_3207 9114163 49.47 µM 2.40397438150963 0.00530219166967552 no 61 0.00810895488864366 41 849233
SGTC_2478 5763493 32.33 µM 2.39072285833586 0.00552159898741864 no 62 0.00840762025770837 35 1365576 YLR208W SEC13
SGTC_127 0180-0333 59.125 µM 2.36751512079668 0.00592534608248711 no 63 0.00895399412362991 17 771601
SGTC_3257 9139206 32.98 µM 2.35214763372147 0.00620690064867934 no 64 0.00933268251704955 29 4910041
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 2.351388254407 0.00622111581206874 no 65 0.00935175328621153 41 1377
SGTC_1893 st059353 36.1 µM 2.33413590052853 0.00655193310842122 no 66 0.00979430349549434 41 3112488
SGTC_915 methyl methanesulfonate (MMS) 110 mM 2.32951557869424 0.00664312913330126 no 67 0.00991588433856012 55 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2012 4023501 200 µM 2.32188458963821 0.00679620840234267 no 68 0.0101195754051493 48 3477460
SGTC_3034 9090421 49.47 µM 2.31710474246573 0.00689367288887153 no 69 0.0102490133707392 17 17173761
SGTC_3302 9125395 16.351 µM 2.31484124102145 0.00694025643308276 no 70 0.010310811009381 31 17599668
SGTC_1736 st036774 51 µM 2.31362158762812 0.00696547231442632 no 71 0.0103442442358775 34 1272247
SGTC_212 3807-4682 38.772 µM 2.29224265443217 0.00742079736762794 no 72 0.0109458224318934 53 3125501 YBL034C STU1
SGTC_1305 1181-0477 144 µM 2.29137069488658 0.00743991246036299 no 73 0.0109709914982424 41 6252086
SGTC_616 4092-0450 108 µM 2.27899378531691 0.0077159549672979 no 74 0.0113337173661153 27 787165
SGTC_417 st075190 100 µM 2.27806641315333 0.00773699663176168 no 75 0.0113613104971558 29 222757
SGTC_2844 9010103 25.97 µM 2.26739208192738 0.00798285265147773 no 76 0.0116831423821061 41 2480525
SGTC_2475 5812728 15.03 µM 2.26324514589544 0.00808020380515999 no 77 0.0118102908256937 53 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_588 3970-1144 52.9 µM 2.25247445604697 0.00833794072279766 no 78 0.0121461525884843 12 1888707
SGTC_1263 0774-1208 64.8 µM 2.25200276099573 0.00834939129818581 no 79 0.0121610487688468 46 906585
SGTC_846 0335-0850 148 µM 2.25109994212281 0.00837134607549233 no 80 0.0121896040474916 32 6819598
SGTC_2967 9089538 49.85 µM 2.24108478987858 0.00861831529421585 no 81 0.0125102916226079 46 728216
SGTC_2585 alliin 100 µM 2.23283772066202 0.00882645925893862 no 82 0.0127798239010298 40 87310 A garlic compound which reacts with lipids.
SGTC_898 1000-0849 28.3 µM 2.22950990804628 0.008911688067792 no 83 0.0128899984043356 45 6751807
SGTC_2318 6029776 164 µM 2.22632740078672 0.00899386913019839 no 84 0.01299612970209 41 818325
SGTC_459 nigericin 15.3 µM 2.19614466470056 0.00980685655956224 no 85 0.0140407952744477 52 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2211 7117706 200 µM 2.19220851209681 0.00991747364357088 no 86 0.0141822270582205 18 822771
SGTC_155 k072-0202 43.6 µM 2.17690874672757 0.0103578523195496 no 87 0.0147436883463848 45 5857737
SGTC_696 1560-0013 611 µM 2.16914645196216 0.0105877263704196 no 88 0.0150357835018419 50 1650269
SGTC_3063 1327-0034 4 µM 2.16773581886261 0.0106299749581609 no 89 0.015089396266388 39 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1913 st060213 96.1 µM 2.15052173678582 0.0111574864574522 no 90 0.0157569842494513 31 688959
SGTC_1861 st057647 17.4 µM 2.13700524583074 0.0115875004341132 no 91 0.0162987824757673 32 688668
SGTC_3226 9131256 49.47 µM 2.13357232392284 0.0116989805637767 no 92 0.0164389027510484 17 17178073
SGTC_2510 benzyl isothiocyanate 8.31 µM 2.12716703298343 0.0119094755641757 no 93 0.0167031036169203 70 2346 DNA damaging agent; causes G2/M arrest.
SGTC_401 neomycin 50 µM 2.12694472177687 0.0119168399202768 no 94 0.0167123382081813 31 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1301 naphtanilide LB 4.81 µM 2.12633063374233 0.0119372029369207 no 95 0.0167378695276377 59 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2752 diclazuril 33.15 µM 2.12082613133094 0.0121210826382863 no 96 0.0169682183964805 46 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2867 9039098 71.43 µM 2.11837223885964 0.0122038438273853 no 97 0.0170717775309385 50 6463460
SGTC_1706 st031321 9.9705 µM 2.11625540239791 0.0122756302992771 no 98 0.0171615457700238 31 6103185
SGTC_2013 4024628 200 µM 2.10443953104307 0.0126830894485548 no 99 0.0176700620743602 53 5230760
SGTC_513 4245-1575 41.7 µM 2.10132109658724 0.0127925583137504 no 100 0.0178063945292749 90 719745
SGTC_983 1491-0821 12.2 µM 2.09818374816258 0.0129035149926297 no 101 0.0179444583460498 50 46495113
SGTC_773 4358-1457 44.6 µM 2.0931885222527 0.0130818955653797 no 102 0.0181661644662211 51 1186886
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 2.08874591615391 0.0132423287496812 no 103 0.0183653006092135 36 756377
SGTC_591 4299-0174 154 µM 2.07525154729293 0.0137401078064297 no 104 0.0189816137407851 31 5509088
SGTC_2121 5257820 149.641 µM 2.07227428464402 0.0138520810083555 no 105 0.0191199345861654 37 791256
SGTC_1540 guanosine 70.6 µM 2.06766285311455 0.0140270675869738 no 106 0.0193358686398358 30 6802 Guanosine is a purine nucleoside
SGTC_1232 0279-0259 161 µM 2.06169420310356 0.0142563819711426 no 107 0.0196184294119279 43 1560000
SGTC_617 3770-0098 35 µM 2.05722307660401 0.0144302705314445 no 108 0.0198323863757706 56 5962639
SGTC_992 3909-8734 162 µM 2.05639059277172 0.0144628478812499 no 109 0.0198724411624299 47 4288319
SGTC_2487 5918373 44.05 µM 2.0545943100164 0.0145333570467903 no 110 0.0199591028564601 65 2876279
SGTC_778 3456-2434 196 µM 2.05443709942525 0.0145395420619764 no 111 0.0199667027202982 43 5539063
SGTC_725 1497-0963 19 µM 2.05159458234364 0.0146517644303043 no 112 0.0201045395735035 39 3549977
SGTC_1377 2944-0135 198 µM 2.04798063922956 0.0147955180692391 no 113 0.0202809482475602 45 1894137
SGTC_3024 9090631 49.47 µM 2.04140668422105 0.0150601251331104 no 114 0.0206052103087183 28 25236383
SGTC_2272 7805186 180 µM 2.04134719568637 0.015062538043147 no 115 0.0206081645302094 44 2956062 YPR165W RHO1
SGTC_3219 9131112 49.47 µM 2.03515843106516 0.0153153819426413 no 116 0.0209174671050845 67 17612988 YMR079W SEC14
SGTC_130 0136-0219 337.655 µM 2.010223618926 0.0163713620574367 no 117 0.0222037633477439 55 234244
SGTC_1297 1068-0111 14.1 µM 2.00739064092683 0.0164951921520563 no 118 0.022354042288632 44 767057
SGTC_1176 0848-0131 83.3 µM 1.99996512649744 0.0168235741852635 no 119 0.0227520148679508 48 6769040
SGTC_903 1134-0042 114 µM 1.99787446308848 0.016917033250088 no 120 0.0228651359258949 49 701009
SGTC_1230 0170-0365 3.77 µM 1.99749578562911 0.0169340086947061 no 121 0.0228856759087273 71 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1755 st041960 45.185 µM 1.98909277347748 0.0173144655852814 no 122 0.0233454819181416 61 2257073
SGTC_1996 st072960 66.8 µM 1.98298634277761 0.0175955015117175 no 123 0.023684477537864 48 1719405
SGTC_1872 amphotericin b 148 nM 1.98097823364941 0.0176887672859569 no 124 0.0237968573022901 53 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2639 lactacystin 53 µM 1.9744169169185 0.0179964513447609 no 125 0.0241671780153834 56 3870 A proteasome inhibitor.
SGTC_2839 9003951 25.97 µM 1.95921514221263 0.0187268947556787 no 126 0.025043798271594 42 2990634
SGTC_2551 apiole 73.87 µM 1.95108042913939 0.0191280265316062 no 127 0.0255237394569009 27 10659 A possible DNA adduct former.
SGTC_3160 9100216 49.47 µM 1.94136726860014 0.0196165400549553 no 128 0.0261068727493889 36 17191039
SGTC_2316 5844804 197.44 µM 1.94082331632966 0.0196442080331098 no 129 0.0261398559229262 75 776813
SGTC_1924 st058459 75.1 µM 1.93445691828354 0.019970503951327 no 130 0.0265284870518878 39 688683
SGTC_184 1494-0393 24.714 µM 1.93351492501601 0.0200191721329477 no 131 0.0265863981430301 105 3090647
SGTC_3042 9091578 49.47 µM 1.92916583695772 0.0202451747914924 no 132 0.0268551389158348 36 25236497
SGTC_2854 9024559 71.43 µM 1.91838106219763 0.0208149617008316 no 133 0.0275313552781858 58 3163529
SGTC_3250 9135583 49.47 µM 1.91562187027969 0.0209628989639306 no 134 0.0277066218595653 46 7699353
SGTC_1222 0366-0074 1.18 µM 1.91499765626698 0.0209964900698083 no 135 0.0277464012537489 52 286520
SGTC_3347 9188721 44.724 µM 1.91303513438597 0.0211023970163679 no 136 0.0278717773653669 56 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_36 0335-0881 14.2 µM 1.91117658709275 0.0212031093337389 no 137 0.0279909457957938 100 23828853
SGTC_3125 9127534 49.47 µM 1.90886751751111 0.0213288009400549 no 138 0.0281395921285537 37 1639235
SGTC_2975 9084847 53.72 µM 1.89555563368986 0.0220657671984298 no 139 0.0290094143053432 66 27211724
SGTC_1587 estradiol valerate 56.1 µM 1.88948302218811 0.0224090295001892 no 140 0.0294135678038802 56 13791 A steroid.
SGTC_132 0417-1715 25.805 µM 1.88819306912238 0.0224825228496738 no 141 0.0295000179737435 53 6769098
SGTC_1251 0490-5699 265 µM 1.88777047982466 0.0225066434660068 no 142 0.0295283849220535 59 3883818
SGTC_1031 k035-0009 16 µM 1.88396851624506 0.0227246354197411 no 143 0.029784617123037 46 5180959
SGTC_2002 4023503 131 µM 1.87995325899865 0.0229567862162182 no 144 0.0300572241996599 79 4736863 YCR052W RSC6
SGTC_195 4234-0266 16.654 µM 1.87713462492241 0.0231209423477762 no 145 0.0302498224296936 84 2303354
SGTC_3039 9090270 49.47 µM 1.87609276354841 0.0231818696104124 no 146 0.0303212715989385 45 17173750
SGTC_2350 9023895 38.85 µM 1.87033151019595 0.0235212287480989 no 147 0.0307188982123577 59 2997209
SGTC_664 1222-0054 14.9 µM 1.86965770319652 0.0235611900750485 no 148 0.0307656833377263 68 6813991
SGTC_1187 1391-0724 117 µM 1.86351359101002 0.0239282190246851 no 149 0.031195021093793 55 6997986
SGTC_1490 4089-0339 670 nM 1.85922796545245 0.0241870630797325 no 150 0.0314974162341957 59 742542
SGTC_3313 9133968 57.047 µM 1.85226425538064 0.0246126725236658 no 151 0.0319939429344694 40 1494643
SGTC_3124 9127567 49.47 µM 1.84428627998273 0.0251079783366272 no 152 0.0325707149629503 51 17592030
SGTC_3259 9138485 49.47 µM 1.84316384130374 0.0251783298500943 no 153 0.0326525462401425 49 17646153
SGTC_3195 9113082 49.47 µM 1.84296898697036 0.0251905596213519 no 154 0.0326667693321033 44 17018038
SGTC_1653 st012112 65 µM 1.8428107981625 0.0252004917907901 no 155 0.0326783198375462 41 720429
SGTC_1373 2887-0003 58.5 µM 1.8418173073204 0.025262944956831 no 156 0.0327509387852126 91 776948
SGTC_3143 9086658 49.47 µM 1.83576066199146 0.0256464912072123 no 157 0.0331965308991883 72 25236626
SGTC_1015 4130-4525 82 µM 1.8327004599257 0.0258421295314782 no 158 0.0334235644349813 64 1363237
SGTC_495 decylubiquinone 155 µM 1.83194090305901 0.0258908808848178 no 159 0.0334801128501375 56 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1146 3579-1023 7 µM 1.82482807746073 0.0263511553287905 no 160 0.0340134887024238 72 X1146
SGTC_2767 sibutramine 71.45 µM 1.82032575724832 0.0266460225042355 no 161 0.0343547055745001 46 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_927 2425-1185 123 µM 1.81444300676742 0.0270354456224302 no 162 0.034804774838909 78 730375
SGTC_1316 1272-0050 65.9 µM 1.80200143206535 0.0278747054136633 no 163 0.0357725901259945 59 7340392
SGTC_3014 9081533 49.47 µM 1.7957784151319 0.0283025615917661 no 164 0.0362648824535858 75 21367265
SGTC_3032 9089427 49.47 µM 1.79390913207847 0.0284321444193311 no 165 0.0364138368130711 53 17173707
SGTC_3077 9117319 49.47 µM 1.77954018413727 0.0294448016350299 no 166 0.0375756214586045 62 17154678
SGTC_119 0121-0043 24.815 µM 1.77948903676994 0.029448459061381 no 167 0.0375798103510408 103 1092378
SGTC_2918 7977171 22.06 µM 1.77017866785881 0.0301205325010001 no 168 0.0383486909006249 58 2236483
SGTC_293 4049-0273 38.5 µM 1.76767009520002 0.0303037741627819 no 169 0.0385580360871674 70 1380311
SGTC_757 1066-0008 322 µM 1.76409859029326 0.0305662520495711 no 170 0.0388576908930648 69 6842497
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.76345877060291 0.0306134721408663 no 171 0.0389115725599918 69 688761
SGTC_402 epigallocatechin gallate 10 µM 1.75720911723477 0.0310778949533753 no 172 0.0394410859037604 73 65064 An antioxidant.
SGTC_2791 5663188 71.43 µM 1.75407150552407 0.0313132453827148 no 173 0.0397091277355958 95 54690634
SGTC_873 0591-4978 488 µM 1.75384678510372 0.0313301579401954 no 174 0.0397283819926656 72 3305145
SGTC_1148 3909-7663 27.7 µM 1.75195779265582 0.0314726231681166 no 175 0.03989053289983 52 4084526
SGTC_1446 4239-0190 62 µM 1.73760575756227 0.0325726144843489 no 176 0.0411401523194073 81 1340085
SGTC_2182 6325192 200 µM 1.73257529759602 0.0329655942190085 no 177 0.041585591501152 57 736248
SGTC_2216 7189485 200 µM 1.73073092872035 0.0331106518042026 no 178 0.0417498831053124 58 731273
SGTC_2284 7945075 39.21 µM 1.73046540982723 0.0331315778110678 no 179 0.0417735780674989 69 1245402
SGTC_2214 7179297 48.276 µM 1.72957167987894 0.0332020943002585 no 180 0.0418534147523417 40 769744
SGTC_2281 7943571 200 µM 1.72784608969225 0.0333385954674822 no 181 0.0420079108622591 77 1244024
SGTC_514 4466-0038 2.65 nM 1.72720071783525 0.0333897655887816 no 182 0.0420658109916386 114 5722064
SGTC_3217 9129673 49.47 µM 1.72547587020882 0.0335268424395221 no 183 0.0422208743431156 72 17248312
SGTC_953 1188-0045 9.7 µM 1.72338064387642 0.0336939767617501 no 184 0.0424098564394242 81 6144426
SGTC_674 0498-0004 451 µM 1.7141346049081 0.0344397330787644 no 185 0.0432520038416119 108 4231473
SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.69636403143593 0.0359111301400805 no 186 0.0449084805221436 52 77254
SGTC_58 0957-0393 9 µM 1.69004228088501 0.0364468303203584 no 187 0.0455099330120464 135 6997992
SGTC_3165 9101544 49.47 µM 1.68275110584433 0.0370727809569785 no 188 0.0462116419114301 75 5002184
SGTC_497 capsazepine 133 µM 1.68084195524976 0.0372381260016342 no 189 0.04639680845704 68 2733484 A calcium channel blocker.
SGTC_3000 9075062 71.4286 µM 1.68066982695643 0.0372530630122629 no 190 0.0464135322323222 79 17057871
SGTC_1378 2093-0007 380 nM 1.67849187433777 0.0374424853374733 no 191 0.0466255577128275 81 3618014
SGTC_1811 st050069 61.5 µM 1.67660260221125 0.0376074368259154 no 192 0.0468101087932674 58 3877702
SGTC_2806 7952793 58.44 µM 1.67659449254012 0.0376081461543756 no 193 0.0468109022370717 81 2972490
SGTC_2703 st077852 53.4 µM 1.67606412996035 0.037654559090472 no 194 0.0468628159198908 78 6281836
SGTC_1476 4112-3294 3.34 µM 1.67456038203397 0.0377864089413288 no 195 0.0470102589622623 63 704369
SGTC_960 1222-0186 7.7 µM 1.67421637511937 0.0378166246492696 no 196 0.0470440411952248 84 3126296
SGTC_3176 9106582 49.47 µM 1.67310784753241 0.037914125894848 no 197 0.0471530334740293 30 17018027
SGTC_916 4466-0038 42 nM 1.6716094018587 0.0380462485641988 no 198 0.0473006847990803 107 5722064 YGL116W CDC20
SGTC_2963 9082507 9 µM 1.66155737982306 0.0389423071499623 no 199 0.0483007774661483 86 16459611
SGTC_426 0988-0037 14.6 µM 1.65389354033711 0.0396369619831721 no 200 0.0490745726898807 95 5383008
SGTC_108 0509-0257 621.132 µM 1.65261347107548 0.0397539644065021 no 201 0.0492047773438832 90 536624
SGTC_1636 st007707 68.9 µM 1.65191466749464 0.0398179556796405 no 202 0.0492759737917169 75 403051
SGTC_2724 maprotiline 69.64 µM 1.64504012370185 0.0404519496460021 no 203 0.0499807684882118 75 4011 A tricyclic antidepressant.
SGTC_1546 5-methoxyflavanone 78.7 µM 1.64299972075487 0.0406416920401107 no 204 0.0501914955184133 59 147795
SGTC_1779 st039427 55 µM 1.63980917200449 0.0409398367663351 no 205 0.0505224252660766 74 1124498
SGTC_1323 1348-1351 11.2 µM 1.63811933942451 0.041098462452675 no 206 0.0506984007148277 72 6989654
SGTC_214 4373-3496 70 µM 1.63750743377988 0.0411560252015037 no 207 0.0507622434785487 123 3779166
SGTC_350 k064-0020 19.8 µM 1.63638366686364 0.0412619096517884 no 208 0.0508796576753528 83 2790705
SGTC_1720 st037298 9.481 µM 1.63237714567036 0.0416412136779283 no 209 0.0513000303083267 82 597396
SGTC_2638 epoxomicin 18 µM 1.63077089927371 0.0417940707014226 no 210 0.0514693350092157 65 9915668 A protesome inhibitor.
SGTC_3309 9129340 25.759 µM 1.63019730800676 0.0418487659907011 no 211 0.0515299013525104 58 17158987
SGTC_2191 5911152 200 µM 1.62947222101283 0.0419179902136825 no 212 0.0516065454397459 73 2875902
SGTC_1691 st019933 84.6 µM 1.62858277286582 0.0420030326147059 no 213 0.0517006867956835 81 6176082
SGTC_1822 st052468 42 µM 1.62814458013948 0.0420449806592521 no 214 0.0517471163487773 70 2873678
SGTC_976 1348-1067 47.6 µM 1.62641403335613 0.042210976840415 no 215 0.051930803748571 77 5310671 YGL099W LSG1
SGTC_3157 9099274 49.47 µM 1.62339452311508 0.0425018815698768 no 216 0.0522525473818864 70 17217662
SGTC_1809 st050081 57.6 µM 1.62042276594967 0.0427897666534921 no 217 0.0525707463701179 82 5036894
SGTC_906 1165-0455 526 µM 1.61880386086988 0.0429472579168822 no 218 0.0527447355868694 65 3252859
SGTC_2885 9057732 51.95 µM 1.61814239966519 0.0430117412060637 no 219 0.0528159564070522 92 6471414
SGTC_850 0388-0143 75.9 µM 1.61451202663752 0.0433670462691072 no 220 0.0532082051577896 79 67273
SGTC_1191 1487-1166 10.6 µM 1.6129000437927 0.0435255691260506 no 221 0.0533831128457291 63 3955771
SGTC_1170 0310-0127 64.8 µM 1.6075706912852 0.0440529909989712 no 222 0.0539646177532734 95 774975
SGTC_451 chloral hydrate 100 µM 1.60455474335683 0.0443537416168771 no 223 0.0542959139413428 111 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1679 SEC14.276 6.7 µM 1.60305780954452 0.0445036292638981 no 224 0.0544609457932751 114 1005053 YMR079W SEC14
SGTC_676 falcarinol 140 µM 1.60184065589747 0.0446258031558947 no 225 0.0545954250722523 92 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2520 obtusaquinone 4.71 µM 1.60136145692004 0.0446739776334428 no 226 0.0546484421679952 95 5967872
SGTC_1974 st069448 26.9 µM 1.60042747930235 0.0447679919488438 no 227 0.0547518915518905 74 6323587 YNR016C ACC1
SGTC_3181 9108277 49.47 µM 1.59452274345455 0.0453660566858251 no 228 0.0554095004333961 103 17097298
SGTC_2814 7977482 42.97 µM 1.59038944288273 0.0457885115986909 no 229 0.0558735242558971 108 6456762
SGTC_2457 5731572 11.68 µM 1.58868219562319 0.0459639254382807 no 230 0.0560660802816987 100 2865357
SGTC_1742 st038235 28.8875 µM 1.58633291684417 0.0462061880290957 no 231 0.0563319045256353 95 564103 YBR002C RER2
SGTC_3315 9136395 68.55 µM 1.58521748524357 0.0463215721676711 no 232 0.0564584645562513 115 16876844
SGTC_37 0566-0070 1.56 µM 1.5800906868671 0.0468548844577878 no 233 0.0570430499000723 83 1626686
SGTC_3168 9103419 49.47 µM 1.57864410166504 0.0470062522518116 no 234 0.0572088564818429 54 16649256
SGTC_210 3551-0445 56.827 µM 1.57558994504351 0.0473271209505958 no 235 0.0575601674430753 82 2865180 YOR207C RET1
SGTC_1157 4092-0394 27.6 µM 1.57485297038598 0.0474048095543624 no 236 0.05764519315343 77 3659885
SGTC_2809 7964133 12.99 µM 1.56601706783298 0.0483442300586822 no 237 0.0586723107394633 101 1253665
SGTC_1141 3253-0389 52.6 µM 1.56285765416533 0.0486837265671349 no 238 0.059043039867086 98 5402031
SGTC_2621 lithochol-11-enic acid 100 µM 1.56284890229402 0.0486846696442614 no 239 0.0590440693676794 91 6708711
SGTC_1643 st009866 20.2 µM 1.55253284150965 0.0498064922206269 no 240 0.0602673904339142 90 3156273 YOR207C RET1
SGTC_489 paxilline 115 µM 1.55174352378201 0.049893169095723 no 241 0.060361802036164 86 105008 A toxic potassium channel blocker.
SGTC_3246 9135460 32.98 µM 1.54648432702169 0.0504737694550008 no 242 0.0609938211833876 90 41446951
SGTC_755 1995-0008 37.3 µM 1.54631433626562 0.0504926253798226 no 243 0.0610143356449913 55 689533
SGTC_947 3447-0010 211 µM 1.54612742092342 0.0505133651120899 no 244 0.061036898788684 102 748350
SGTC_1118 chelidonine 707.474 nM 1.5371546137335 0.0515169765437347 no 245 0.0621277258191343 67 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1101 ebselen 5.29 µM 1.53593386569796 0.0516547346054618 no 246 0.0622773006105433 113 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_349 k015-0014 24 µM 1.53578619322433 0.0516714188756813 no 247 0.062295413526244 100 2196908
SGTC_510 ag-490 170 µM 1.53515868198995 0.0517423638761582 no 248 0.0623724273750253 66 5328779
SGTC_2273 7815444 169.05 µM 1.53457019655608 0.0518089670408236 no 249 0.0624447190688705 103 2824616
SGTC_2208 7283366 200 µM 1.52958894088645 0.0523754648348823 no 250 0.0630592542862438 88 898663
SGTC_1655 st012546 55.1 µM 1.527495276525 0.0526150318337242 no 251 0.0633189504416529 77 720985 YLR208W SEC13
SGTC_2303 7774051 200 µM 1.52395137634501 0.0530225226491066 no 252 0.063760429008497 102 2953184
SGTC_2019 4016004 108 µM 1.52224560215637 0.0532195491140558 no 253 0.0639737763351176 108 45595336
SGTC_1910 st062352 60.4 µM 1.51963340879629 0.0535223964972852 no 254 0.0643015682056005 77 2245730
SGTC_883 0850-0245 24.6 µM 1.51248804988394 0.0543577798103052 no 255 0.065204875214413 119 6823229 YPR165W RHO1
SGTC_1271 0832-2808 169 µM 1.51167149451195 0.0544538986752093 no 256 0.0653087268822426 109 3663794
SGTC_1427 4048-4900 550 nM 1.51114503434674 0.0545159409201592 no 257 0.0653757514798056 97 24132586
SGTC_3188 9110789 49.47 µM 1.51103088787568 0.0545294002182869 no 258 0.0653902907097862 99 849217
SGTC_639 0833-0042 114 µM 1.51054413568307 0.0545868238949984 no 259 0.065452318168868 114 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2644 guaiazulene 100 µM 1.50800780038032 0.0548868174445407 no 260 0.0657762653105345 65 3515 A coloring agent.
SGTC_3276 9139060 49.47 µM 1.50790530217658 0.0548989681008086 no 261 0.0657893827192958 122 4870619
SGTC_1887 st057648 70.8 µM 1.50644154006987 0.0550727219307203 no 262 0.0659769318620101 120 688672
SGTC_1738 st035555 74 µM 1.50460233704131 0.055291657554122 no 263 0.0662131725410261 102 5331140
SGTC_558 k064-0027 21.3 µM 1.5004602398643 0.0557872429031207 no 264 0.0667476126814579 107 5088526
SGTC_1370 2001-0092 44.6 µM 1.49678499549539 0.0562298998424829 no 265 0.0672246058634403 101 790957
SGTC_2179 6298986 200 µM 1.49034996443714 0.057011617607212 no 266 0.0680661206862176 88 738374
SGTC_488 nitrendipine 139 µM 1.4843681432791 0.0577459298756806 no 267 0.0688556406647369 82 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1100 amiodarone 5.07 µM 1.48367350798145 0.0578316811903216 no 268 0.0689477788571751 74 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1828 st055811 49 µM 1.48193559495432 0.0580466615768522 no 269 0.0691787163803217 69 5877589
SGTC_2386 9075165 157.42 µM 1.48185398650774 0.0580567719840721 no 270 0.0691895753143109 99 16452277
SGTC_1569 carminic acid 40.6 µM 1.48157530636733 0.0580913078826063 no 271 0.0692266667833424 88 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3190 9110366 49.47 µM 1.48137847055626 0.0581157108133555 no 272 0.0692528742542198 85 17123768
SGTC_1423 4048-0112 5.59 µM 1.4806048219252 0.0582117027864617 no 273 0.0693559548508611 99 X1423
SGTC_2829 7992743 58.44 µM 1.48051946322654 0.0582223014600125 no 274 0.0693673352408722 83 16462845
SGTC_2340 7987427 183.45 µM 1.47583656668936 0.058806085811658 no 275 0.0699938858446612 86 2239331
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.47165296730231 0.0593315023955039 no 276 0.0705573071975008 90 6710655
SGTC_589 1227-0070 34.1 µM 1.47016560664664 0.0595191838311513 no 277 0.0707584535902236 98 2841384
SGTC_569 4130-2812 160 µM 1.46850799118394 0.0597288966580414 no 278 0.0709831435882302 95 743552
SGTC_1386 3228-0095 33.8 µM 1.46841180447193 0.0597410834460235 no 279 0.0709961985131463 85 870181
SGTC_772 k072-0172 35.3 µM 1.46771307635674 0.059829670287174 no 280 0.0710910886273812 82 5861980
SGTC_2812 7970281 58.44 µM 1.46572451174878 0.0600823496691383 no 281 0.0713616767984296 119 2233435
SGTC_2998 9066762 71.4286 µM 1.46406059322873 0.0602944189313816 no 282 0.0715886965801181 95 4945196
SGTC_3269 9137823 49.47 µM 1.46208558982662 0.0605468964013869 no 283 0.0718588785289263 65 17682936
SGTC_42 0133-0086 60.653 µM 1.46102360990952 0.0606829977055676 no 284 0.0720044811135518 139 162923 Model of phenazepam hydroxylation.
SGTC_165 k038-0023 64.381 µM 1.45379498288724 0.0616157719054649 no 285 0.0730015774408721 114 46368543
SGTC_2683 piperine 63.03 µM 1.45223077219673 0.0618190818501702 no 286 0.0732187245385919 100 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2119 5528445 120.635 µM 1.44786445694636 0.0623893697142762 no 287 0.0738274808491094 100 791935
SGTC_299 1273-0059 1.44 µM 1.44432497804885 0.0628546676488893 no 288 0.0743237914099938 105 2848077
SGTC_1808 st050063 61.5 µM 1.44430683478272 0.0628570596987468 no 289 0.0743263420306589 98 4011993
SGTC_994 3910-0338 138 µM 1.439718195172 0.0634643171109132 no 290 0.0749735717244672 115 3479481
SGTC_1622 st003707 19.4 µM 1.43084283314534 0.0646518228473225 no 291 0.0762376320178837 103 10140899
SGTC_680 0417-1641 114 µM 1.43070207277814 0.0646707943770055 no 292 0.0762578094646262 110 2835990
SGTC_2564 betulinic acid 100 µM 1.42748547432398 0.0651055033399548 no 293 0.0767200045704053 102 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2740 felodipine 17.08 µM 1.42701224907144 0.0651696485294911 no 294 0.0767881819829764 63 3333 L-type calcium channel blocker
SGTC_3025 9087895 49.47 µM 1.42188552201407 0.065867718233493 no 295 0.0775297434206157 100 17173641
SGTC_3015 9080845 49.47 µM 1.42136000575966 0.0659396002365734 no 296 0.0776060635680026 109 5296973
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.4212512352832 0.0659544858436465 no 297 0.0776218673072832 110 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_812 4251-0442 148 µM 1.42036365292594 0.0660760518231334 no 298 0.0777509193709909 111 5723007
SGTC_695 3505-6186 243 µM 1.41614839208508 0.0666557579575502 no 299 0.0783660310821117 120 1819379
SGTC_3038 9091290 49.47 µM 1.41310519094758 0.0670767168664867 no 300 0.0788123985891926 92 25236843
SGTC_1434 4073-0095 163 µM 1.41246611106474 0.0671653799538911 no 301 0.0789063811549823 107 24133745
SGTC_1011 4112-3381 17.4 µM 1.41003991917966 0.0675028042117928 no 302 0.0792639480112871 107 2877139
SGTC_972 1319-0219 195 µM 1.4088251772441 0.0676722366504338 no 303 0.0794434342262224 119 23903702
SGTC_2103 5378138 10 µM 1.40273069985808 0.0685272589069635 no 304 0.0803485795095337 98 244142
SGTC_1080 nisoldipine 24.4 µM 1.39522701983339 0.0695914027882762 no 305 0.0814736957523909 117 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_168 3970-0862 530.542 µM 1.39099841320395 0.0701966681694512 no 306 0.0821129539660541 169 3135186
SGTC_1988 st071872 53.4 µM 1.38715451575787 0.070750373559714 no 307 0.0826973257623469 89 16414116
SGTC_2654 protoveratrine a 100 µM 1.38323337620584 0.0713186571137378 no 308 0.0832966594478602 117 5702278 A heart drug and vasodilator.
SGTC_1572 epiandrosterone 68.9 µM 1.3823568456337 0.0714461689546451 no 309 0.083431079809936 103 441302 A steroid.
SGTC_1122 capsaicin 818.572 nM 1.38101904108125 0.0716411210744896 no 310 0.0836365530699314 110 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_369 0957-0393 4.5 µM 1.37967900926288 0.0718368066364432 no 311 0.0838427493346563 111 6997992
SGTC_2586 curcumin 80 µM 1.37828063847012 0.0720414482870995 no 312 0.0840583293154882 119 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2359 9039622 200 µM 1.3756040146483 0.0724343992807525 no 313 0.0844721315479283 104 6463596
SGTC_2771 fluoxetine 41.05 µM 1.37320362625611 0.0727881913209264 no 314 0.0848445263482557 96 3386 A selective serotonin reuptake inhibitor.
SGTC_416 estradiol valerate 100 µM 1.37134466147988 0.0730630911195603 no 315 0.0851337697258848 118 13791 A steroid.
SGTC_3021 9087658 49.47 µM 1.37113691974864 0.0730938608199026 no 316 0.0851661388965433 79 25237042
SGTC_1875 nocodazole 6 µM 1.36712590931337 0.073689898158554 no 317 0.085792921719226 109 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_149 3970-0822 46.1 µM 1.36357210818201 0.0742210920624514 no 318 0.0863511377361482 131 3114250 YBL034C STU1
SGTC_1644 st010134 20.9 µM 1.36173868671414 0.0744962783900025 no 319 0.0866401837449609 120 3818134
SGTC_1701 st028638 40.4 µM 1.36098937134844 0.0746089703916699 no 320 0.0867585241690497 99 3490878
SGTC_447 ml7 120 µM 1.36018558630836 0.07472999885556 no 321 0.0868856012979486 90 4216 Selective myosin light chain kinase inhibitor.
SGTC_2399 5884133 200 µM 1.35410020212294 0.0756511600009913 no 322 0.0878522058685947 119 722445
SGTC_985 1493-0307 8.71 µM 1.35242247900226 0.0759066365182293 no 323 0.0881201011877988 114 3278274
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.34801767408059 0.0765805078971191 no 324 0.0888263490506392 115 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1886 st057356 49.9 µM 1.34113773061202 0.0776421300621652 no 325 0.0899378695491383 109 24207747
SGTC_3080 9117754 49.47 µM 1.34103791430174 0.0776576142123568 no 326 0.0899540715507837 127 9550191
SGTC_2338 7999974 200 µM 1.33826054452655 0.0780893984692305 no 327 0.090405759393624 133 315925
SGTC_1380 2291-0730 164 µM 1.33760169839529 0.0781920928530289 no 328 0.0905131552561341 109 2999191
SGTC_651 3253-0966 34.4 µM 1.33601543295602 0.0784397643046661 no 329 0.0907721145106494 119 781462
SGTC_627 1391-0720 175 µM 1.33464756286644 0.0786538137908458 no 330 0.0909958616457615 140 997839
SGTC_163 TUB2.036 7.546 µM 1.33383924073118 0.0787805110177081 no 331 0.0911282737977579 157 15992207 YJR013W GPI14
SGTC_623 k072-0108 16.9 µM 1.3338050798969 0.0787858688250078 no 332 0.0911338728675777 134 5382803
SGTC_2712 st079126 47.7 µM 1.3324915889003 0.0789920870595851 no 333 0.091349351776971 104 3152970
SGTC_3126 9127922 49.47 µM 1.32966058023451 0.0794379455682148 no 334 0.0918150641876786 169 45595682
SGTC_223 busulfan 5 mM 1.32686501206366 0.0798800889554546 no 335 0.0922766700125306 101 2478 A DNA alkylator.
SGTC_1059 3448-6867 171 µM 1.32484497070693 0.0802007325118519 no 336 0.0926112878611819 137 3934407
SGTC_3193 9111931 49.47 µM 1.31963128106525 0.0810328023664934 no 337 0.0934790768218705 112 17087244
SGTC_2891 9063876 19.48 µM 1.31959218782433 0.0810390659017808 no 338 0.0934856062769276 93 6472478
SGTC_759 3486-0358 89.3 µM 1.3170971128337 0.0814395841735113 no 339 0.0939030373406427 139 875103
SGTC_1265 0819-1001 68.8 µM 1.31583464608095 0.0816428077565705 no 340 0.0941147739589758 128 3106768
SGTC_2693 st077581 40.7 µM 1.3146193645679 0.0818387967159079 no 341 0.0943189293655699 121 25238761
SGTC_508 roscovitine 141 µM 1.30747416177093 0.082998283768046 no 342 0.0955258623068295 142 160355 A CDKinase inhibitor.
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.30732666149437 0.0830223488605175 no 343 0.0955508965246053 143 6708760
SGTC_302 1094-0063 18.9 µM 1.30435048183558 0.0835090430329249 no 344 0.0960570552480473 152 5440289
SGTC_3154 9100113 49.47 µM 1.30075489488478 0.0840998849220685 no 345 0.0966711827807489 127 25237525
SGTC_1144 3486-0183 12.5 µM 1.2967938051111 0.0847544146960961 no 346 0.0973510713877133 136 6744069
SGTC_3320 9137005 35.139 µM 1.29518006637736 0.0850221609933468 no 347 0.0976290598005677 144 4908713
SGTC_3109 9122853 49.47 µM 1.29351850048088 0.0852985045383287 no 348 0.0979158948352836 149 1234709
SGTC_1877 wortmannin 25 µM 1.29181519917056 0.0855824872078444 no 349 0.0982105752265953 129 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1421 4029-0249 71.4 µM 1.2915612471855 0.0856248878905539 no 350 0.0982545658914755 128 2894095
SGTC_1630 st005209 31.3 µM 1.2889048784416 0.086069347333044 no 351 0.0987155789270344 122 3367314
SGTC_1703 st026983 48.3 µM 1.28878541096042 0.0860893769281278 no 352 0.0987363496568252 111 1104023
SGTC_1207 2099-0101 141 µM 1.28235479467051 0.0871726694021145 no 353 0.0998591071719365 133 5837381
SGTC_1976 st070609 63.5 µM 1.28176097891615 0.0872732138439746 no 354 0.0999632532340371 124 682556
SGTC_2243 6634756 200 µM 1.28015165373768 0.0875461388450438 no 355 0.100245902622657 94 885676
SGTC_86 0417-1630 471.922 µM 1.27580188775652 0.0882870010699377 no 356 0.101012780047864 164 3634867
SGTC_1449 4112-4002 201 µM 1.27255878500356 0.0888424072353384 no 357 0.101587325819125 114 2059539
SGTC_1790 st045711 43.5 µM 1.27083407430163 0.0891388347396691 no 358 0.10189384190764 90 585119
SGTC_2641 levomentholum 100 µM 1.26955200244904 0.0893596619987211 no 359 0.102122127858735 116 16666
SGTC_2624 nerol 100 µM 1.26704254731089 0.0897930742376496 no 360 0.102570038418845 132 637566 A natural product oil.
SGTC_597 k018-0003 82.8 µM 1.2644066626649 0.0902500029570947 no 361 0.103042051352449 132 6786234
SGTC_1040 k898-0338 155 µM 1.2580226092457 0.0913638270431781 no 362 0.104191789844898 132 20969351
SGTC_987 1497-1013 404 µM 1.25736794236898 0.0914786201594718 no 363 0.104310215963555 130 1676435
SGTC_1448 4255-0083 152 µM 1.25630895849523 0.0916645348410855 no 364 0.104501987579997 158 5399660
SGTC_1965 Pectolinarigenin 58.4 µM 1.25595334537943 0.0917270288495257 no 365 0.10456644289035 125 5320438 An anti-inflammatory.
SGTC_1523 st012844 44.7 µM 1.25490881108934 0.0919107735892196 no 366 0.104755932521576 105 4274103
SGTC_619 1652-1634 108 µM 1.25207207443039 0.0924111610900129 no 367 0.10527180114124 131 5400454
SGTC_1262 0737-0114 49.6 µM 1.24877878999055 0.0929946068108436 no 368 0.105872996835819 145 765919
SGTC_2279 7948423 32.93 µM 1.2487367451649 0.0930020731307117 no 369 0.105880688212675 119 1247112
SGTC_3274 9138298 49.47 µM 1.24762250734695 0.0932001009818514 no 370 0.10608466601683 146 17015756
SGTC_1785 bathophenanthroline 24 µM 1.24415539366437 0.0938182865853792 no 371 0.106721188563298 160 72812 An iron chelator.
SGTC_2584 androsterone 48.74 µM 1.24345764104697 0.09394306073909 no 372 0.106849620459757 147 2754130 A steroid.
SGTC_556 4058-0063 51.5 µM 1.24027473877195 0.0945137903030002 no 373 0.107436896287565 136 6615692
SGTC_2275 7947463 200 µM 1.23406823450186 0.0956340300951784 no 374 0.108588739546094 140 1225414
SGTC_810 3825-7150 143 µM 1.23033015809418 0.0963134295679802 no 375 0.109286747688119 99 22330411 YGL099W LSG1
SGTC_2953 9074162 66.49 µM 1.22922840044396 0.0965143504560836 no 376 0.109493091754825 127 16451992
SGTC_894 0960-0238 55.9 µM 1.22844838207826 0.0966567837629674 no 377 0.10963934754101 162 6741907 YDL195W SEC31
SGTC_741 4582-0002 126 µM 1.2280056784481 0.0967376912032609 no 378 0.109722418169512 154 2912688
SGTC_2997 9067075 71.4286 µM 1.22527401440629 0.0972380240175647 no 379 0.110235997860378 151 27209819
SGTC_1967 st070177 51.4 µM 1.22523840091397 0.0972445595162813 no 380 0.110242704913272 138 5729214
SGTC_1563 conessine 56.1 µM 1.22523702109814 0.0972448127353557 no 381 0.110242964778477 95 441082 An anti-amoebic, histamine inhibitor.
SGTC_3026 9090633 49.47 µM 1.22477203139416 0.0973301736091304 no 382 0.110330562824325 128 25236842
SGTC_378 3970-0959 8.33 µM 1.22069139467244 0.0980816389514183 no 383 0.111101443583099 155 6615653
SGTC_2413 inermin 26.06 µM 1.22067309285462 0.0980850188521256 no 384 0.111104909680477 173 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_129 0088-0017 176.636 µM 1.22039833804899 0.0981357696407848 no 385 0.111156953541072 125 182446
SGTC_2305 7443522 69.23 µM 1.21958067372939 0.0982869166948028 no 386 0.111311938204794 149 5415886
SGTC_3311 9131146 2.8755 µM 1.21733052867673 0.0987037410680847 no 387 0.111739241692134 178 4900406 YPR165W RHO1
SGTC_2184 6075246 200 µM 1.21225400616492 0.099648882103469 no 388 0.112707582028241 130 2267320
SGTC_2190 6049624 200 µM 1.21192423249258 0.0997105069389175 no 389 0.112770692583264 137 2265554
SGTC_2367 9070478 135.38 µM 1.21137358831917 0.0998134679178116 no 390 0.112876128542689 150 572802
SGTC_2334 9017922 200 µM 1.21042519142239 0.0999909838403359 no 391 0.113057890135762 125 3163164
SGTC_1788 fluconazole 20 µM 1.21023098967755 0.100027361917411 no 392 0.113095134921867 145 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2925 9010536 32.5 µM 1.20929665973307 0.100202516694197 no 393 0.113274446842617 120 2994177
SGTC_683 panaxydol 45 µM 1.20741125019961 0.100556647763442 no 394 0.113636902531811 104 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1228 0124-0032 52.5 µM 1.20178624030042 0.101618601085995 no 395 0.114723178931559 118 X1228
SGTC_472 calcifediol 10 µM 1.20150476265653 0.101671955375178 no 396 0.114777730067684 116 5283731 A vitamin D metabolite.
SGTC_337 1315-0038 354 µM 1.19994368176286 0.101968229649597 no 397 0.115080606807549 114 1626437
SGTC_2132 5317594 122.667 µM 1.19983336467557 0.101989190242031 no 398 0.115102031713263 148 794577
SGTC_1477 0139-0234 16 µM 1.19546395762296 0.102821914435711 no 399 0.115952905024926 145 620880
SGTC_2036 5160441 105 µM 1.1919119689256 0.103502486475509 no 400 0.11664788229172 176 134534 YIL048W NEO1
SGTC_1424 4048-1941 275 µM 1.18919870114464 0.104024555214137 no 401 0.11718074275911 138 X1424
SGTC_1973 st070275 50.2 µM 1.18628914598373 0.104586511021319 no 402 0.117754065772173 113 17118334
SGTC_3103 9120822 49.47 µM 1.18556804824143 0.104726124329371 no 403 0.117896463330164 180 17141819
SGTC_852 0418-0143 439 µM 1.18409363258503 0.105012009188392 no 404 0.118188000196317 145 5369229
SGTC_305 1682-2595 20.8 µM 1.18144137124481 0.105527696134827 no 405 0.118713715591738 152 226033
SGTC_491 tetrandrine 80.3 µM 1.1777647454458 0.106245578668831 no 406 0.119445203512797 132 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_756 0508-1999 28.3 µM 1.17654842132032 0.106483847744697 no 407 0.119687897480443 153 6753853
SGTC_158 k038-0087 26.446 µM 1.1758854973567 0.106613872057042 no 408 0.119820317469171 153 X158
SGTC_1499 4480-0877 67.3 µM 1.17409017134866 0.106966578332696 no 409 0.12017945493091 128 2861909
SGTC_1272 0839-0021 27 µM 1.17394019284621 0.10699608086936 no 410 0.120209490959379 156 5027250
SGTC_124 0136-0217 7.121 µM 1.17132573016837 0.107511319723204 no 411 0.120733936410562 174 3976905
SGTC_448 monastrol 171 µM 1.1687115887556 0.108028280615751 no 412 0.121259925637307 144 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_908 3448-7491 47.7 µM 1.1685915424227 0.108052063349132 no 413 0.121284118701824 141 1203031
SGTC_3215 9129942 49.47 µM 1.16840127005476 0.108089766491866 no 414 0.121322471446822 157 17682944
SGTC_283 0987-0079 11.7 µM 1.16754609618654 0.108259339166877 no 415 0.12149495209032 127 411556
SGTC_2442 5158906 48.48 µM 1.1671660365808 0.10833476271976 no 416 0.12157166189055 152 1893835
SGTC_2098 5376439 882.5 nM 1.1659078183106 0.108584728330914 no 417 0.12182585880413 140 2844116
SGTC_843 0310-0051 143 µM 1.1649354962114 0.108778179977342 no 418 0.122022551932192 153 2065037
SGTC_1135 dihydrocapsaicin 536.708 nM 1.16312481417214 0.10913909059069 no 419 0.122389432836782 152 107982 A Capsaicinoid.
SGTC_1034 k072-0165 12.7 µM 1.1625071807361 0.109262395754585 no 420 0.122514754794328 168 5835461
SGTC_1081 sertraline 6 µM 1.16180628743154 0.109402444227668 no 421 0.122657079770514 160 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2793 7325131 81.82 µM 1.16018259494931 0.109727376344393 no 422 0.122987235880555 149 4176441
SGTC_1810 st050138 53 µM 1.15907334478222 0.109949756598018 no 423 0.123213144936535 175 3444541
SGTC_936 3005-4620 401 µM 1.15337349521963 0.111097551993855 no 424 0.124378557791598 160 777207
SGTC_2596 sinensetin 100 µM 1.15077016991939 0.111624636099516 no 425 0.124913399950876 146 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2819 7996655 46.38 µM 1.14852128951514 0.112081395563398 no 426 0.125376714713458 119 6456960
SGTC_880 0833-0487 87.2 µM 1.14799119712999 0.112189254436502 no 427 0.125486098926355 156 76075
SGTC_2027 5150920 200 µM 1.14713435318424 0.112363754888754 no 428 0.1256630489116 131 786715
SGTC_3258 9138477 49.47 µM 1.14625226604573 0.1125435987397 no 429 0.125845393739172 152 4970355
SGTC_3331 9141060 1.957 µM 1.14594194510089 0.112606917218813 no 430 0.125909587065128 136 4906567 YPR165W RHO1
SGTC_910 3454-3003 490 µM 1.14585536726704 0.112624587264164 no 431 0.125927500722872 178 820824
SGTC_2989 9073649 71.4286 µM 1.14507592672863 0.112783755830149 no 432 0.12608885333448 172 21367202
SGTC_1035 k081-0041 55.2 µM 1.14391000227366 0.113022147492202 no 433 0.126330481245795 159 731709
SGTC_714 4296-0578 26.1 µM 1.14389182030148 0.113025867929046 no 434 0.126334251858025 158 1589775
SGTC_1603 st002045 67.8 µM 1.1400744503145 0.113808923473606 no 435 0.127127642640444 148 5887985
SGTC_779 1360-0071 233 µM 1.13891355892181 0.114047821539166 no 436 0.127369604866005 162 7566
SGTC_1408 3909-7976 48.8 µM 1.13870751627734 0.114090260042477 no 437 0.127412583362385 154 24152374
SGTC_1946 st076057 65.1 µM 1.13777723992974 0.114282008657721 no 438 0.127606755546373 137 953009
SGTC_2576 guaiol 23.12 µM 1.13668091678895 0.114508277290413 no 439 0.127835849856569 157 227829
SGTC_1969 st069479 40.1 µM 1.13569178358219 0.114712696618172 no 440 0.128042790246069 151 3895485
SGTC_479 n-linoleoylglycine 10 µM 1.13565741329843 0.114719804421923 no 441 0.128049985167476 163 6433346 An anti-infammatory.
SGTC_412 gemfibrozil 100 µM 1.13334649982265 0.115198422332527 no 442 0.12853438581836 142 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1654 st012436 41.8 µM 1.13071772386605 0.115744597286766 no 443 0.129086959507116 143 4323132
SGTC_2206 7254556 146.969 µM 1.12941607402048 0.116015717934777 no 444 0.129361177597227 126 4398905
SGTC_1851 st056236 18.9 µM 1.12903230185619 0.116095739826691 no 445 0.129442103737444 154 5393171
SGTC_492 tmb-8 126 µM 1.12780822399335 0.116351239009714 no 446 0.129700459720568 141 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1824 st053723 68.6 µM 1.12705961890293 0.116507690217205 no 447 0.129858637477557 138 675225
SGTC_1508 1080-0625 72.9 µM 1.12526994759899 0.116882318762567 no 448 0.130237330229709 152 767111
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.12295673254993 0.11736780365698 no 449 0.130727935442401 158 688669
SGTC_300 r073-0011 5.04 µM 1.11996341674812 0.117998141550104 no 450 0.131364675964684 156 2735780
SGTC_1756 st041558 35.5 µM 1.11717047694307 0.118588440076081 no 451 0.131960720599437 162 3955792
SGTC_222 nsc-310342 10.666 µM 1.11062781590263 0.119979417928681 no 452 0.13336429231288 145 432556
SGTC_1167 k781-0610 148 µM 1.109535165358 0.120212832902542 no 453 0.133599691498719 169 4525169
SGTC_901 1112-0062 60.1 µM 1.10920578990378 0.120283257699816 no 454 0.13367070772129 149 1908457
SGTC_2545 solidagenone 89.61 µM 1.10547199581216 0.121083624599334 no 455 0.134477561180573 116 6708572 An anti ulcer agent
SGTC_1844 rapamycin 4 nM 1.10388790269308 0.121424316310581 no 456 0.134820883582375 190 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2549 cedrol 20.94 µM 1.10191789189182 0.121848947009533 no 457 0.135248684698634 173 6708665 A sedative which affects the nervous system.
SGTC_1803 st050068 52.4 µM 1.10188957354165 0.121855058552335 no 458 0.135254840996242 168 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1801 st050089 28.441 µM 1.10137344225548 0.121966485485869 no 459 0.135367079560416 171 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2196 6573537 42.6665 µM 1.09398498021196 0.123569419724801 no 460 0.136980782833979 172 2903087
SGTC_884 0851-0618 334 µM 1.0926327408672 0.123864379342224 no 461 0.137277540723779 169 9642473
SGTC_999 SEC7.066 22.7 µM 1.0901872111743 0.12439906567255 no 462 0.137815342834367 184 740511 YDR170C SEC7
SGTC_2311 7694451 200 µM 1.08777220474383 0.124928660308927 no 463 0.138347841471708 196 2163142
SGTC_2935 9038016 29.96 µM 1.08736624043027 0.125017839960103 no 464 0.138437492378893 163 6463195
SGTC_339 3091-4833 71.4 µM 1.08368997438608 0.125827443442729 no 465 0.139251141148075 184 3240077
SGTC_1984 st072354 53.1 µM 1.08357491410518 0.125852841405049 no 466 0.139276659248032 168 5762938
SGTC_2871 9038510 12.99 µM 1.08338984461601 0.125893700429977 no 467 0.13931771068356 199 4945164
SGTC_2100 5377183 190 µM 1.08326022374155 0.125922323202712 no 468 0.139346467612402 173 2844202
SGTC_1302 1159-0335 255 µM 1.08290731348008 0.126000275547149 no 469 0.139424782682499 149 649284
SGTC_1735 st034310 56.75 µM 1.08252405853662 0.126084968660442 no 470 0.139509865512782 180 871153
SGTC_587 k089-0003 57 µM 1.08102555181056 0.126416495205957 no 471 0.139842873839041 147 9659696
SGTC_2015 5119600 184 µM 1.08076375835331 0.126474476116304 no 472 0.139901106751515 185 2828786
SGTC_435 c-PAF 6.7 µM 1.08009170145175 0.126623405259491 no 473 0.140050673450748 169 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2768 sulfasalazine 50.2 µM 1.07885296342258 0.126898232012722 no 474 0.140326639994776 152 5384001 An antioxidant and salicylic acid derivative.
SGTC_1384 3089-0840 101 µM 1.07598729762864 0.127535599981788 no 475 0.140966468668978 131 1069836
SGTC_1333 1482-0047 286 µM 1.0749543649712 0.12776588486794 no 476 0.141197580103564 169 3811116
SGTC_3223 9129970 49.47 µM 1.06886889798919 0.129128462106067 no 477 0.142564374156936 190 17248386
SGTC_3343 9148379 18.9835 µM 1.0667221102924 0.129611537660264 no 478 0.143048669911728 158 1955036
SGTC_2102 5377816 72.7585 µM 1.06638370704792 0.129687800075994 no 479 0.143125111899958 182 1379702
SGTC_1525 8-methoxypsoralen 92.5 µM 1.06450029908905 0.130112811905621 no 480 0.143551059491728 173 4114 Related to psoralen; DNA damaging agent.
SGTC_3074 9116018 49.47 µM 1.062851497225 0.130485672759056 no 481 0.143924650797145 186 17027303
SGTC_3174 9107204 49.47 µM 1.06215875705765 0.130642549600721 no 482 0.144081809774362 171 3938802
SGTC_392 N-ethylmaleimide 8.33 µM 1.06166286770637 0.130754927969077 no 483 0.144194381097152 171 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_942 3253-1115 227 µM 1.06069937131776 0.130973466371701 no 484 0.144413272893501 181 46497897
SGTC_2436 5633522 8.09 µM 1.05964280439118 0.131213404832466 no 485 0.144653566199931 175 5724242
SGTC_2895 9054447 58.44 µM 1.05021442086812 0.133367963585226 no 486 0.14680977039648 178 2697450
SGTC_1044 1222-0021 1.78 µM 1.04788511403622 0.133903981019757 no 487 0.147345770732236 195 4306703
SGTC_950 1165-0508 94.1 µM 1.04564792873539 0.134420191668017 no 488 0.147861806047821 170 6148369
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.04516464009592 0.134531885457431 no 489 0.14797344146863 178 4213774
SGTC_2456 5770359 74.46 µM 1.04416818145619 0.134762380030372 no 490 0.14820379267971 187 3118787
SGTC_2431 5490079 200 µM 1.04221175181577 0.135215717004885 no 491 0.148656757882121 197 5722345
SGTC_79 0052-0007 94.094 µM 1.04033749023163 0.135650993833594 no 492 0.149091566119369 171 2801472
SGTC_2245 6637752 200 µM 1.03992989154411 0.135745781117656 no 493 0.149186236909021 169 681890
SGTC_3155 9099265 49.47 µM 1.03788860604608 0.136221165515666 no 494 0.149660959351407 168 25236499
SGTC_2781 5567276 71.43 µM 1.03299960476352 0.137364367261607 no 495 0.150802041809881 183 2853274
SGTC_1052 3253-3998 198 µM 1.03225954694077 0.137537985223667 no 496 0.15097527314004 162 5450317
SGTC_1889 st059080 5.18 µM 1.02971932828811 0.138135061091159 no 497 0.151570889824641 147 176925 Isolated from Daphnopsis sellowiana.
SGTC_274 sirtinol 40.1 µM 1.02880962428025 0.138349315297042 no 498 0.151784571640817 167 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_3336 9143619 71.43 µM 1.0265268465915 0.138887953855773 no 499 0.152321657915932 162 45595730
SGTC_1878 temozolomide 1 mM 1.02643187112187 0.13891039493107 no 500 0.152344030810754 168 5394 DNA alkylating agent.
SGTC_1452 4194-0072 190 µM 1.02638684681617 0.13892103426524 no 501 0.152354637722618 176 1343545
SGTC_2492 derrusnin 100 µM 1.02504606808429 0.139238117269724 no 502 0.152670725582485 197 1715307 Part of coumarin class of compounds.
SGTC_2150 5556613 200 µM 1.02452351883362 0.139361829085727 no 503 0.152794034011536 181 743190
SGTC_693 4161-2696 114 µM 1.02444675124448 0.139380009857838 no 504 0.152812154787178 200 805759
SGTC_1883 5-benzylidenerhodanine 20 µM 1.02422054350234 0.13943359173653 no 505 0.152865558781671 181 1273210
SGTC_3201 9113999 49.47 µM 1.02384715334405 0.13952206739672 no 506 0.152953737238493 159 16649224
SGTC_3115 9123671 49.47 µM 1.02285187770314 0.139758086758769 no 507 0.153188942615718 182 3286988
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.02193194763616 0.139976479943524 no 508 0.153406555235768 171 17037758
SGTC_1412 3909-8563 178 µM 1.02155850534569 0.140065202013762 no 509 0.153494952701021 196 23767530
SGTC_1114 scopoletin 1.73284 µM 1.0159779044541 0.141395587988169 no 510 0.154819954272636 173 5280460 A coumarin with genotoxic properties.
SGTC_2449 5812982 45.77 µM 1.01278086400827 0.142161591986331 no 511 0.155582421488309 161 776185
SGTC_1053 3366-3204 134 µM 1.01194159395915 0.14236314381524 no 512 0.155782990094443 184 3632071 YPR165W RHO1
SGTC_1715 st032160 10.2275 µM 1.01193319901489 0.142365160848396 no 513 0.155784997177537 162 5289825
SGTC_3233 9132340 49.47 µM 1.011583200852 0.142449271274438 no 514 0.155868690738528 211 17682950
SGTC_1845 st056753 3.01 µM 1.01032612472817 0.142751644864747 no 515 0.156169534350997 163 5375839
SGTC_1948 st076329 66.6 µM 1.00977936752034 0.142883295625173 no 516 0.156300503662781 169 24208413
SGTC_787 4152-0075 138 µM 1.00781371743391 0.143357271686394 no 517 0.15677194964984 169 9566539
SGTC_1286 0929-0070 131 µM 1.00672439487038 0.143620396102903 no 518 0.157033617845515 185 1420408
SGTC_1549 4'-methoxyflavonol 74.6 µM 1.00603301497022 0.143787566983692 no 519 0.157199844438249 185 97141
SGTC_2616 abietic acid 100 µM 1.00454792180107 0.144147095967923 no 520 0.157557292401533 191 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1155 4088-0394 48.2 µM 1.00309289248837 0.14449993410263 no 521 0.157908021837376 178 2326248
SGTC_2025 5147754 141 µM 1.00307263617255 0.144504850272669 no 522 0.157912908162867 178 315777 YLR208W SEC13
SGTC_2799 7812892 81.82 µM 1.00287681037659 0.144552382638761 no 523 0.157960151318399 216 20205235
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.00174051196238 0.14482840174392 no 524 0.158234467501567 173 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2823 7987624 58.44 µM 1.00141033703452 0.144908671285859 no 525 0.15831423430332 193 2239440
SGTC_1196 1588-0294 184 µM 1.00045926057288 0.145140056924432 no 526 0.158544151836159 184 6144269
SGTC_2977 9011197 71.43 µM 1.00023829747649 0.145193850203411 no 527 0.158597599788658 196 2704722
SGTC_574 1315-0397 40 µM 0.998564891637702 0.145601674945877 no 528 0.159002757315271 218 6794277
SGTC_2865 9030313 51.95 µM 0.997716176530626 0.145808808905303 no 529 0.159208503391925 164 42562754
SGTC_1178 0988-0033 191 µM 0.997505827573083 0.145860176428291 no 530 0.159259523277261 182 5392207
SGTC_3298 9116858 71.43 µM 0.997260418787041 0.145920120982376 no 531 0.159319060413371 196 2506942
SGTC_2123 5259487 200 µM 0.992585361595022 0.147065231250554 no 532 0.160456030692968 171 2173474
SGTC_743 1275-0778 158 µM 0.990451325656475 0.147589940484638 no 533 0.160976784516968 213 2849257 YMR203W TOM40
SGTC_3266 9136860 49.47 µM 0.985544394556767 0.148801191052287 no 534 0.162178368020105 196 4871271 YPR165W RHO1
SGTC_1198 1612-1005 86.7 µM 0.982500218184005 0.149555960164641 no 535 0.16292673776205 221 6998509
SGTC_2257 7960413 200 µM 0.981419756264422 0.149824461739468 no 536 0.163192893784875 193 2974689 YIL048W NEO1
SGTC_1416 3966-0321 25.3 µM 0.979226703750131 0.150370437128599 no 537 0.163733988498975 194 582530 YLR208W SEC13
SGTC_2941 9056145 11.23 µM 0.97816601651441 0.150634977503209 no 538 0.163996110617069 176 2119517
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.97457564098934 0.151532732966592 no 539 0.16488540073414 185 140250 A respiratory chain inhibitor.
SGTC_359 0081-0058 15.9 µM 0.974002011969551 0.15167649491302 no 540 0.165027770119837 195 3494159
SGTC_865 0488-0499 301 µM 0.973336959707629 0.151843282635264 no 541 0.165192929501796 182 9634651
SGTC_377 3970-0964 33.1 µM 0.973105602951116 0.151901332899217 no 542 0.165250409817586 186 16481235
SGTC_904 1141-0088 396 µM 0.972062426679073 0.152163261786667 no 543 0.165509746481157 174 1378119
SGTC_3224 9130643 49.47 µM 0.971246776117898 0.152368270529677 no 544 0.165712702878068 200 17644395
SGTC_315 k915-0449 187 µM 0.970850172552487 0.152468020606287 no 545 0.165811446923511 192 20970215 YNL149C PGA2
SGTC_3012 9080433 71.4286 µM 0.970740108437549 0.152495710599265 no 546 0.165838856786821 201 17688859
SGTC_2618 avocadyne 43.43 µM 0.96937906694053 0.152838397963234 no 547 0.166178046356165 171 3015189
SGTC_1892 st058411 7.36 µM 0.967633780268258 0.153278578531349 no 548 0.16661365020028 191 3934738
SGTC_2770 toltrazuril 17.5 µM 0.967244157137162 0.153376960364155 no 549 0.166710996267117 181 68591 Kills coccidiodes.
SGTC_3134 9127454 49.47 µM 0.966218074326826 0.153636251622471 no 550 0.166967535260275 179 24262820
SGTC_1330 1469-0054 61.8 µM 0.965361695732038 0.153852880680416 no 551 0.167181839990623 189 7102664
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.965183628797681 0.153897949769648 no 552 0.167226422665405 189 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_224 benfluorex 43.875 µM 0.959374203029326 0.155373119062633 no 553 0.168685133036098 192 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_12 0849-0099 9.267 µM 0.955503517711089 0.156361152791792 no 554 0.169661563642575 195 6071388
SGTC_3029 9088683 49.47 µM 0.955226982534071 0.15643189938334 no 555 0.169731461718399 187 25236615
SGTC_686 1319-0111 510 µM 0.953732559551586 0.156814585554413 no 556 0.170109517247903 202 4562600
SGTC_536 3852-0578 10.6 µM 0.953500324801503 0.156874110608171 no 557 0.170168315846491 192 2869208
SGTC_710 3448-4187 58 µM 0.950311516436759 0.157692950718324 no 558 0.170976994447508 198 3946412
SGTC_3312 9133330 71.43 µM 0.950281036564155 0.157700791033787 no 559 0.17098473595559 206 17617324
SGTC_304 1310-0298 97 µM 0.947825421404759 0.158333288483221 no 560 0.171609168313096 224 1550234
SGTC_543 3844-1095 191 µM 0.942198040066059 0.159789012481921 no 561 0.173045628591874 232 4230703
SGTC_1870 st057514 26.5 µM 0.941265010833053 0.160031217528402 no 562 0.173284534279666 202 5393161
SGTC_808 0711-0032 135 µM 0.940672472978009 0.160185158998923 no 563 0.173436364836267 212 4252555
SGTC_2213 7173844 200 µM 0.93938764459651 0.160519290119299 no 564 0.173765877121012 204 892728
SGTC_874 0599-0792 117 µM 0.937749071546964 0.160946075836795 no 565 0.174186689560461 205 765305
SGTC_1753 st043925 64 µM 0.937010119751025 0.161138786672642 no 566 0.174376676228392 192 670181
SGTC_662 k832-1615 104 µM 0.936754806635594 0.161205404621848 no 567 0.174442348565425 196 5878478
SGTC_1666 st014829 29 µM 0.934960345770483 0.161674133816483 no 568 0.174904367858806 186 3858230
SGTC_667 1498-1044 59 µM 0.934594909567628 0.161769697778307 no 569 0.174998551694934 219 6739982
SGTC_1717 st033143 58.0435 µM 0.932663941309558 0.162275269640779 no 570 0.175496754054525 185 674616
SGTC_2898 9056270 58.44 µM 0.932624376181171 0.1622856394432 no 571 0.175506971504469 147 19154699
SGTC_1209 2323-2347 50.3 µM 0.931848325701958 0.162489125215326 no 572 0.175707457966836 190 5412760
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.929504933240049 0.163104586015253 no 573 0.176313734901966 181 1241132 A phosphatase inhibitor.
SGTC_532 1548-0774 215 µM 0.926634738094976 0.163860466104628 no 574 0.177058106158056 205 5932993
SGTC_572 0960-0087 17.7 µM 0.926493621300899 0.163897688450802 no 575 0.177094755253658 243 6796365
SGTC_81 0411-0046 9.971 µM 0.925715112184105 0.164103134253196 no 576 0.177297026078418 218 12925265
SGTC_2667 digitoxin 100 µM 0.925421671165957 0.164180615629508 no 577 0.177373305233276 166 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3016 9080866 49.47 µM 0.924171254009337 0.16451104684084 no 578 0.177698579820271 201 17066299
SGTC_1650 st011916 45.8 µM 0.923099778355771 0.164794534217666 no 579 0.177977605067398 211 242528
SGTC_602 3130-1533 38.1 µM 0.921573591455736 0.165198873572785 no 580 0.178375519366646 226 720941
SGTC_1085 doxorubicin 7.67 µM 0.918242910767944 0.166083513074814 no 581 0.179245853999641 221 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1250 0485-0349 40.2 µM 0.917259753795355 0.166345226723092 no 582 0.179503270784212 197 6842794 YDL195W SEC31
SGTC_2959 9079155 11 µM 0.916297487844813 0.16660163697922 no 583 0.179755442636641 201 16189457
SGTC_2398 5228213 48.84 µM 0.915023616367387 0.166941471382112 no 584 0.18008961612436 225 80771 YMR134W ERG29
SGTC_557 1315-0110 16.2 µM 0.912219433594542 0.167691125535283 no 585 0.180826607872896 197 6833801
SGTC_932 2857-0803 154 µM 0.909845428408474 0.168327470376398 no 586 0.181452016438666 197 674898
SGTC_2074 5212007 75.395 µM 0.907087310562531 0.169068723178511 no 587 0.182180313943636 198 758611
SGTC_1439 4092-1168 46 µM 0.904945370009444 0.169645820299662 no 588 0.182747164741355 206 2886240
SGTC_2958 9077254 16.72 µM 0.904238450457984 0.169836560687876 no 589 0.182934487867282 206 16457351
SGTC_50 0929-0078 56.389 µM 0.903195908004768 0.170118109379886 no 590 0.183210964626461 187 1377751
SGTC_692 k241-0027 77.8 µM 0.902621453734449 0.170273374062332 no 591 0.183363418169875 204 3600480
SGTC_2537 larixol 68.93 µM 0.902462241346974 0.170316422376558 no 592 0.183405685297299 208 6708759
SGTC_27 0485-0001 32.618 µM 0.90203985427058 0.170430662417824 no 593 0.183517848516534 204 2054479
SGTC_648 0375-0473 33.3 µM 0.900282106576817 0.170906594883333 no 594 0.18398507047723 219 1713139
SGTC_1798 st045719 60.953 µM 0.900116206510686 0.170951558304144 no 595 0.184029206125278 206 3980186
SGTC_2904 7225135 42.03 µM 0.899794460297659 0.171038781829843 no 596 0.184114821488283 245 4446116
SGTC_1675 st018485 24.5 µM 0.898165256252733 0.17148088648325 no 597 0.18454872661637 226 3323024
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.8974151695083 0.171684677090386 no 598 0.184748710481344 219 616764
SGTC_22 0964-0034 14.468 µM 0.896698130380635 0.171879633586459 no 599 0.184940009272337 242 138402
SGTC_2894 9048625 32.47 µM 0.895054582429614 0.172327032638867 no 600 0.185378955444298 228 4092861
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.892540778130287 0.173012764672905 no 601 0.186051572938633 203 61125 An anti-inflammatory.
SGTC_2876 9059903 25.97 µM 0.889924127718354 0.173728395602165 no 602 0.186753313717969 197 6916095
SGTC_771 0250-0039 27.3 µM 0.888454494668097 0.174131151939779 no 603 0.187148161628972 238 3005115
SGTC_2177 5811945 192 µM 0.888448059437428 0.174132916833681 no 604 0.187149891723967 204 5343475
SGTC_1762 st045503 25.4615 µM 0.886436705809771 0.174685097614314 no 605 0.187691123528214 207 4645554
SGTC_2352 9027995 87.8 µM 0.886072278717901 0.17478526331399 no 606 0.187789289973789 194 2997347
SGTC_1401 3807-4679 7.6 µM 0.885758433800523 0.174871555311194 no 607 0.187873856407809 222 3291456
SGTC_2480 5767542 37.17 µM 0.885243184330344 0.175013282326811 no 608 0.188012742874706 213 2867358
SGTC_2138 5575593 77.673 µM 0.882110114273945 0.175876647970718 no 609 0.188858631598182 207 762213
SGTC_1793 st048256 72.231 µM 0.879617813514865 0.176565362698526 no 610 0.189533192733703 209 672022
SGTC_2429 5902844 64.44 µM 0.877870474100842 0.177049232764891 no 611 0.190007006988732 218 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2023 5144124 124 µM 0.877347014630258 0.177194351141842 no 612 0.190149091569189 225 2830192
SGTC_375 3970-0961 9.27 µM 0.876877508060294 0.177324576078227 no 613 0.190276587034434 221 2898222
SGTC_2926 9010726 65.15 µM 0.876712317439686 0.177370408629421 no 614 0.190321457369638 205 2994293
SGTC_3013 9080133 71.4286 µM 0.876198041782851 0.177513143580488 no 615 0.190461190451173 223 17050193
SGTC_3296 9122258 64.045 µM 0.875084843360476 0.177822355148491 no 616 0.190763871649003 199 4730474
SGTC_2286 7945697 125 µM 0.874633437551456 0.17794783826771 no 617 0.19088669399136 202 1245733
SGTC_344 k064-0035 6.43 µM 0.874185456390697 0.178072424585347 no 618 0.191008632477304 209 5088750
SGTC_2581 avocatin a 64 µM 0.873955749424668 0.178136328829169 no 619 0.191071176219853 196 6710728 A skin care supplement.
SGTC_1033 k072-0102 21.3 µM 0.873888085778594 0.178155155542538 no 620 0.191089601815353 224 5965931
SGTC_2167 5876490 200 µM 0.87358366408542 0.178239873260813 no 621 0.191172512850324 220 686534
SGTC_2723 salbutamol 83.58 µM 0.873242222995858 0.178334923334752 no 622 0.191265532572758 212 9884233 β2-adrenoceptor agonist
SGTC_2271 7849410 118.62 µM 0.873240005013069 0.178335540879265 no 623 0.191266136914511 233 972430
SGTC_831 k061-1017 217 µM 0.872789651256073 0.178460959075551 no 624 0.191388870670068 226 1240153
SGTC_1977 st070720 65.3 µM 0.870898947481215 0.178988103803691 no 625 0.191904665771456 183 682188
SGTC_866 0495-0101 262 µM 0.867631080387051 0.179901521209792 no 626 0.192798163070879 202 635694
SGTC_2526 patulin 37.61 µM 0.86732363761159 0.179987606445911 no 627 0.192882354401609 224 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2516 gossypol 71.55 µM 0.864629466896531 0.180743091431165 no 628 0.193621096904438 220 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2804 7954240 19.48 µM 0.863278188741877 0.181122757169281 no 629 0.193992266668843 212 828705
SGTC_3297 9117502 71.43 µM 0.863270054385248 0.181125044173822 no 630 0.19399450233002 187 7453720
SGTC_1078 idebenone 36.1 µM 0.862949743695764 0.181215115093238 no 631 0.19408254957509 246 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1000 4048-0884 8.67 µM 0.862839441056877 0.181246138534035 no 632 0.194112875282388 216 13040088
SGTC_1591 genipin 88.4 µM 0.861207594414648 0.181705496132906 no 633 0.194561859046783 218 442424 A DNA cross-linking agent.
SGTC_2748 diazoxide 86.69 µM 0.860873418852756 0.181799654852903 no 634 0.194653881497595 161 3019 A potassium channel activatior.
SGTC_3227 9130768 49.47 µM 0.860596491326067 0.181877706246641 no 635 0.194730159528775 211 17720899
SGTC_352 k048-0007 5.11 µM 0.860397964734391 0.181933673411079 no 636 0.194784853680097 248 6811911
SGTC_876 0720-0963 56.8 µM 0.860197672449801 0.181990149259806 no 637 0.194840043748711 212 765861
SGTC_599 1935-0052 86.5 µM 0.859707393971999 0.18212843794692 no 638 0.194975178959177 197 9557311
SGTC_2078 5212016 200 µM 0.85894408778618 0.182343867945207 no 639 0.195185682050533 211 1899708
SGTC_2404 5161160 200 µM 0.856944116305885 0.182909080100968 no 640 0.195737884967141 242 2831543
SGTC_944 3370-0224 231 µM 0.856470549438354 0.18304307481739 no 641 0.195868778054057 193 4580514
SGTC_1841 st054148 70 µM 0.855511465277399 0.183314633152086 no 642 0.196134029965675 221 675442
SGTC_2428 5615643 7.78 µM 0.854046868000136 0.183729808613708 no 643 0.196539510682541 232 2253075
SGTC_2684 capsaicin 100 µM 0.851271961737558 0.184518027651453 no 644 0.19730914815323 219 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1188 1403-0014 4.57 µM 0.850763490097939 0.184662687957452 no 645 0.197450373288384 221 9614867
SGTC_2968 9090663 33.37 µM 0.850480468965681 0.184743238078666 no 646 0.197529007286898 252 25236811
SGTC_628 1636-0253 16 µM 0.848778706149796 0.18522803404041 no 647 0.198002220549179 237 4456143
SGTC_2531 methyl deoxycholate 70.07 µM 0.847793098950577 0.185509173478177 no 648 0.198276603528817 223 16667744 Haematoxylin.
SGTC_404 fumagillin 50 µM 0.846677411474963 0.185827737038066 no 649 0.198587476298343 242 12015870 A methionine aminopeptidase binder.
SGTC_806 3966-4455 5.86 µM 0.845740957794065 0.186095385503335 no 650 0.198848634543062 205 714982
SGTC_765 1319-0117 244 µM 0.845381338768441 0.186198231932191 no 651 0.198948980104802 207 3487746 YGL099W LSG1
SGTC_83 0170-0301 39.027 µM 0.845099829228009 0.186278764624241 no 652 0.199027551836084 219 3089716
SGTC_2761 levamisole 97.89 µM 0.84457515008614 0.186428919518288 no 653 0.199174044183198 205 26879 An alkaline phosphatase inhibitor.
SGTC_1010 4112-3296 15.2 µM 0.843929338201984 0.18661384359372 no 654 0.19935444638205 212 704384
SGTC_2323 6148992 148.28 µM 0.84246853971499 0.187032552655598 no 655 0.199762871133301 210 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_919 tnp00227 403.569 nM 0.840101485877264 0.187712254618809 no 656 0.20042574353558 227 1269246 A methoxyflavone. YNL221C POP1
SGTC_1657 st012939 43.4 µM 0.839711538726801 0.187824374557241 no 657 0.200535071390228 214 24207257
SGTC_1578 josamycin 24.2 µM 0.838336236979781 0.188220139599506 no 658 0.200920944791494 231 5282165 A P450 substrate.
SGTC_2676 harmalol 100 µM 0.835899959032462 0.188922479467364 no 659 0.201605592738378 220 5459187 A monoamine oxidase inhibitor
SGTC_313 3474-0040 5.03 µM 0.835261082018861 0.189106924357215 no 660 0.201785362337732 246 1043375 YIL048W NEO1
SGTC_2371 9071574 200 µM 0.834823628899012 0.189233281765928 no 661 0.201908509876916 228 45596039
SGTC_782 0083-0095 30.5 µM 0.830666183527653 0.190436744104134 no 662 0.203081117490974 212 3591729 An indicator and reagent.
SGTC_1023 4482-3888 16 µM 0.824025979602721 0.192368616587884 no 663 0.204962398236333 243 3303168
SGTC_288 1315-0019 35.1 µM 0.823717318346555 0.192458707693816 no 664 0.205050098388611 250 6811474
SGTC_647 0140-0236 81 µM 0.823445765487255 0.192537989040403 no 665 0.205127273344722 227 990837
SGTC_2833 9001315 45.46 µM 0.820123538188374 0.193509546932221 no 666 0.206072842494049 220 2989378
SGTC_2689 tacrolimus 100 µM 0.817854854423096 0.194174719865987 no 667 0.206720035686723 224 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2414 st077232 92.9 µM 0.817407382118479 0.194306081974761 no 668 0.206847829200524 207 729801
SGTC_1548 st061468 90.8 µM 0.814682460962691 0.195107190362787 no 669 0.207627047688937 230 390799
SGTC_570 0987-0065 62.6 µM 0.81372606907178 0.19538883840654 no 670 0.207900948193428 223 3104428
SGTC_376 3970-0862 59.1 µM 0.812999977175402 0.19560283019734 no 671 0.208109035626257 251 3135186
SGTC_265 mycophenolic acid 32.932 µM 0.811665595210499 0.195996466421635 no 672 0.208491770563528 232 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2287 7945887 168.79 µM 0.811121218115489 0.196157192949268 no 673 0.208648030991976 231 1245853
SGTC_1293 1000-1278 195 µM 0.809661117646381 0.196588679964688 no 674 0.209067485484861 247 678847
SGTC_101 0490-5701 117.494 µM 0.808085540317643 0.197054937033561 no 675 0.20952067048996 213 4661669
SGTC_1325 1431-0015 227 µM 0.806869086979186 0.197415376769883 no 676 0.209870955256932 206 1103340
SGTC_594 1487-1584 10.8 µM 0.805417209104288 0.197846095199071 no 677 0.210289482143154 237 5013332
SGTC_2899 9053889 58.44 µM 0.805066318577785 0.197950276555381 no 678 0.210390705405993 224 6470052
SGTC_131 0141-0277 33.849 µM 0.804673592796451 0.198066918321153 no 679 0.210504031024276 239 1547771
SGTC_25 0118-0223 35.662 µM 0.802119589083095 0.198826483886994 no 680 0.211241892289771 245 5333628
SGTC_439 amiodarone 34.4 µM 0.801654712084464 0.198964927846822 no 681 0.211376359827396 234 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1792 st045773 43.6 µM 0.800410943059817 0.199335617399136 no 682 0.211736371420079 188 2919270
SGTC_862 0452-0056 10.2 µM 0.800256168122277 0.199381775179008 no 683 0.211781196446647 226 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1143 3454-2408 5.08 µM 0.795968902266796 0.200662902103311 no 684 0.213025055366481 211 X1143
SGTC_1972 st070201 17.4 µM 0.795899868690986 0.200683571161433 no 685 0.213045118795095 222 2829099
SGTC_2490 carminic acid 95.39 µM 0.795574725549573 0.200780938112432 no 686 0.213139630913432 222 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2376 9072922 81.32 µM 0.795057211379855 0.200935970711288 no 687 0.213290111581372 225 17087968
SGTC_966 1300-0360 30.2 µM 0.793929324900696 0.201274102322093 no 688 0.213618288371883 250 70588
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.79248453518418 0.201707737066797 no 689 0.214039102772427 246 5024745
SGTC_701 4424-0219 185 µM 0.792038062506982 0.201841853093185 no 690 0.214169241456975 234 2911779
SGTC_1618 st003135 44.5 µM 0.790232032214388 0.202384911508957 no 691 0.214696136090156 262 1270615
SGTC_2258 7960471 200 µM 0.787827197339981 0.203109380281569 no 692 0.215398895099789 244 2974708
SGTC_2301 7769476 200 µM 0.787364609857189 0.203248914467252 no 693 0.215534228789027 229 977820
SGTC_3173 9105693 49.47 µM 0.786338632523631 0.203558592800556 no 694 0.215834562626232 255 17096658
SGTC_875 0709-0210 25.7 µM 0.781909183860849 0.204898792684172 no 695 0.217133973673426 255 6251364
SGTC_1971 st069429 63.5 µM 0.781288536256486 0.205086997621782 no 696 0.217316405495874 235 1246522 YGL099W LSG1
SGTC_366 0181-0206 4.31 µM 0.77803110873227 0.206076462122204 no 697 0.218275336986394 227 274874
SGTC_930 2810-3379 265 µM 0.776251584363691 0.206618197594578 no 698 0.218800226860614 250 1015764
SGTC_1506 4226-2149 212 µM 0.775528412051577 0.206838591656536 no 699 0.219013741700212 243 991114
SGTC_1295 1013-0063 9.78 µM 0.775243591369328 0.20692543181677 no 700 0.219097867183832 244 6826038
SGTC_6 0844-0013 19.835 µM 0.774549934600036 0.20713701395351 no 701 0.219302825419835 267 1584900
SGTC_751 0833-0568 350 µM 0.774495047785007 0.207153761225103 no 702 0.219319047804831 254 6954252
SGTC_3316 9136639 10.545 µM 0.774421290164516 0.207176267689154 no 703 0.219340848744164 237 4903665
SGTC_837 0091-0265 12.5 µM 0.770007481512504 0.208525732219431 no 704 0.220647727371673 251 759367
SGTC_113 0099-0221 2.5 µM 0.769472811096533 0.208689551939323 no 705 0.22080633953969 249 89219
SGTC_1930 st074634 34.3 µM 0.76629090312986 0.20966603676447 no 706 0.221751614932322 245 684253 YOR116C RPO31
SGTC_1092 toremifene 6.32 µM 0.766286832492788 0.209667287706746 no 707 0.221752825708554 253 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3304 9125678 46.087 µM 0.763806686282259 0.210430273940225 no 708 0.222491225855182 242 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2052 5265182 7.135 µM 0.7638043407774 0.210430996276274 no 709 0.222491924832285 242 1239884
SGTC_675 1309-0189 238 µM 0.763610409370645 0.210490725615928 no 710 0.222549722100502 231 4246530
SGTC_3089 9117425 49.47 µM 0.763491180213681 0.21052745219229 no 711 0.222585260148195 255 9401657
SGTC_1884 5633444 25 µM 0.763253909573694 0.210600550689468 no 712 0.222655991864417 260 5724239
SGTC_75 0159-0059 199.013 µM 0.761986208930184 0.210991357026912 no 713 0.223034117603338 262 5377270
SGTC_1492 4158-0558 28.5 µM 0.760920117041261 0.211320340346079 no 714 0.223352391011646 229 3967268
SGTC_2563 tomatine 8.54 µM 0.758109478996799 0.212189108972468 no 715 0.224192722768038 255 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.757969714695517 0.212232364563769 no 716 0.2242345566629 223 6708630 An antioxidant.
SGTC_1355 1499-0035 1.68 µM 0.756648213227944 0.2126416101608 no 717 0.224630324134909 250 1548538
SGTC_3104 9120930 49.47 µM 0.756060253531512 0.212823838891407 no 718 0.22480653546247 248 17014836
SGTC_463 ikarugamyin 104 µM 0.756052355656252 0.212826287332179 no 719 0.224808902986434 252 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1385 3091-4834 14.1 µM 0.754007634917664 0.213460729476632 no 720 0.225422318624857 231 4072814
SGTC_2991 9074669 71.4286 µM 0.752146379668659 0.214039202621501 no 721 0.22598151757808 258 17333109
SGTC_3229 9132204 49.47 µM 0.749922753029959 0.214731494579329 no 722 0.226650615004901 239 17682924
SGTC_3271 9137798 49.47 µM 0.749840249454101 0.214757205807579 no 723 0.226675462127868 225 6498326
SGTC_1111 tnp00062 510.699 nM 0.749176058445188 0.214964257950886 no 724 0.226875548672169 245 676306
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.746339212985756 0.215849908377329 no 725 0.227731264665991 270 6708784 An antioxidant flavonoid
SGTC_2337 9009472 200 µM 0.745843603058681 0.216004852273138 no 726 0.227880948372967 248 5742383
SGTC_1329 1447-1697 50.6 µM 0.744323849716141 0.216480378473164 no 727 0.228340288002629 241 2840515
SGTC_2940 9060638 45.86 µM 0.741656977050111 0.217316297342492 no 728 0.229147596389894 237 4027022
SGTC_2321 7390090 138.78 µM 0.741577205886348 0.217341329922452 no 729 0.229171769130917 247 649046
SGTC_2007 4011539 71.82 µM 0.741546545786787 0.217350951654076 no 730 0.229181060320362 242 45595301
SGTC_2248 tofa 1.1 µM 0.740772192386156 0.217594040252469 no 731 0.229415789215315 257 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2800 7887935 81.82 µM 0.740393159374975 0.217713085219854 no 732 0.229530734176593 256 2961002
SGTC_2746 daunorubicin 9.88 µM 0.739278890627624 0.218063267209099 no 733 0.229868832384157 227 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2198 6589944 200 µM 0.739011962054617 0.21814720321231 no 734 0.229949866851798 237 5290268
SGTC_659 k018-0002 107 µM 0.738424293892552 0.218332061764972 no 735 0.230128328132405 263 6797879 YHR007C ERG11
SGTC_1552 6-methylflavone 10.6 µM 0.738339081951705 0.218358873762339 no 736 0.230154211466307 256 689013
SGTC_1759 st043059 70 µM 0.736345133052923 0.218986812430744 no 737 0.230760343004449 281 669426
SGTC_1277 0873-0036 22 µM 0.735442554057708 0.219271395671566 no 738 0.231035006801194 257 5965735
SGTC_1086 cerivastatin 2.18 µM 0.734946341290119 0.219427942114534 no 739 0.231186087001821 242 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2648 atorvastatin 78.68 µM 0.734309537685308 0.219628936556428 no 740 0.231380053149942 256 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_560 2332-1943 155 µM 0.733974485472009 0.219734731583937 no 741 0.231482144254679 264 21177716
SGTC_2073 5212005 126 µM 0.732704397660736 0.220136036059005 no 742 0.231869370597505 278 691789
SGTC_733 4069-0007 56.1 µM 0.732571883169861 0.220177930326781 no 743 0.231909792595783 254 5717425 YNL287W SEC21
SGTC_1713 st033146 12.748 µM 0.731700046570079 0.22045367420476 no 744 0.232175833996204 266 674619
SGTC_1482 3346-2049 8.48 µM 0.729678263733223 0.221093883358982 no 745 0.232793435269459 239 3826804
SGTC_3353 9151644 39.2805 µM 0.72959511410311 0.221120235923742 no 746 0.232818854814679 241 4909158
SGTC_967 1306-0166 352 µM 0.729027777356984 0.221300089593184 no 747 0.232992335610097 270 4437607
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.728499962205022 0.221467489466717 no 748 0.233153795895859 273 688798
SGTC_2004 4023728 41.89 µM 0.727181191751782 0.221886062005699 no 749 0.233557483203239 279 360084 YDR527W RBA50
SGTC_1223 0764-0573 147 µM 0.724092836295625 0.222868059726824 no 750 0.234504371142621 247 1609797
SGTC_909 3448-9333 149 µM 0.723548902570724 0.223041269248064 no 751 0.2346713605774 260 3344074
SGTC_1545 lovastatin 49.4 µM 0.722981006650716 0.223222191032285 no 752 0.234845776625404 252 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_3045 9092950 49.47 µM 0.722541755770237 0.22336218601667 no 753 0.234980731463175 264 44120432
SGTC_1941 st076221 61.8 µM 0.722327318829081 0.223430548010884 no 754 0.235046630336858 251 2828568
SGTC_2929 9013348 24.6 µM 0.719837334545405 0.224225220273581 no 755 0.23581257747685 261 2995952
SGTC_3277 9138724 49.47 µM 0.717195763399491 0.22507002276982 no 756 0.236626656515792 236 15943418
SGTC_2491 paeonol 100 µM 0.71695818859776 0.225146090008629 no 757 0.236699947990806 272 11092 Increases levels of cortical cytochrome oxidase.
SGTC_3108 9121785 49.47 µM 0.715495390648904 0.225614772762259 no 758 0.237151494013417 255 17140271
SGTC_2363 9053361 176 µM 0.711122068896382 0.227019279562198 no 759 0.238504297708683 270 6469797 YMR079W SEC14
SGTC_60 0986-0278 202 µM 0.710132452558351 0.227337780802233 no 760 0.238811001743134 289 3110598
SGTC_603 3794-0023 45.9 µM 0.710035880703723 0.227368875269436 no 761 0.23884094305048 280 3802260
SGTC_2906 7926292 26.41 µM 0.70893715174128 0.227722815656272 no 762 0.239181739434787 281 2966319
SGTC_326 k292-0812 17.5 µM 0.708612756482818 0.22782737438492 no 763 0.239282408967869 260 3579357
SGTC_1741 st038134 10.228 µM 0.705378752567626 0.228871230986397 no 764 0.240287281522509 261 1272587
SGTC_1920 st075728 45.7 µM 0.704736724788362 0.229078780581871 no 765 0.240487046152478 252 3400306
SGTC_1895 st058434 18.3 µM 0.702032714221504 0.229954069198504 no 766 0.241329381008203 292 5393175
SGTC_52 0329-0193 875 nM 0.701299740641695 0.230191654928408 no 767 0.241557987778071 286 3739292
SGTC_2946 9065502 71.43 µM 0.698900272418518 0.230970377187313 no 768 0.242307178624738 230 16489101
SGTC_1686 st019653 115.5 µM 0.698471609105995 0.231109650043606 no 769 0.242441153493053 288 97252
SGTC_2136 5328288 199.296 µM 0.697856622394553 0.231309541260369 no 770 0.242633432129714 270 262395
SGTC_1246 0422-0085 105 µM 0.696726858552328 0.231677003407796 no 771 0.242986873442682 281 264295
SGTC_2772 vinpocetine 57.06 µM 0.696657736329812 0.231699496361129 no 772 0.243008507042787 284 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2694 st077685 81.9 µM 0.695952985374805 0.231928897695115 no 773 0.243229136661788 249 2838096
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.694942117899947 0.23225816279921 no 774 0.243545788200872 264 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2917 7979103 53.79 µM 0.693625293650987 0.232687475591528 no 775 0.2439586136004 262 2980565
SGTC_2117 5521686 200 µM 0.693015037901861 0.232886581448198 no 776 0.244150057184031 262 803312
SGTC_3076 9116187 49.47 µM 0.691962990232918 0.233230051216146 no 777 0.244480285615131 253 27241210
SGTC_1689 st020265 53.493 µM 0.690974538068335 0.233553014504933 no 778 0.244790771105121 275 5758320 YPR016C TIF6
SGTC_2595 hexamethylquercetagetin 100 µM 0.690613449447011 0.233671057116892 no 779 0.24490424657733 287 386331
SGTC_2048 5246248 200 µM 0.689473720271956 0.2340438601146 no 780 0.2452626027227 260 677046
SGTC_2162 5663267 200 µM 0.689335313146749 0.234089155212883 no 781 0.245306140181836 278 6456493
SGTC_2438 5259590 200 µM 0.688884046354519 0.234236870438597 no 782 0.245448119884533 270 1201127
SGTC_895 0964-0006 13.7 µM 0.688044212128917 0.234511914547988 no 783 0.245712470033076 292 6738897
SGTC_621 3584-0052 32.1 µM 0.687588366994053 0.234661277733242 no 784 0.245856017961216 287 2273927
SGTC_975 1335-0046 28.5 µM 0.687370364908297 0.234732727350271 no 785 0.245924683822891 288 16486740
SGTC_1606 st000094 49.2 µM 0.687095707380475 0.234822762761475 no 786 0.246011209551506 251 1242210
SGTC_2085 5307070 144.047 µM 0.685439258042655 0.235366167496471 no 787 0.246533389112234 295 2840351
SGTC_3310 9130229 44.1445 µM 0.684607096026434 0.235639423245161 no 788 0.246795944018751 276 7761258
SGTC_462 ag-879 158 µM 0.683865842044435 0.23588297494545 no 789 0.247029942588732 298 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1673 st016611 27.3 µM 0.683644455540731 0.23595574217659 no 790 0.247099852747635 290 5226799
SGTC_2202 7226349 200 µM 0.683151586013021 0.236117787217456 no 791 0.247255530709004 258 844334
SGTC_811 0416-0114 265 µM 0.683004649087892 0.236166108820292 no 792 0.247301952409031 271 6612453
SGTC_1772 st048439 82.2 µM 0.682278885954885 0.236404862795519 no 793 0.247531310675221 260 2927068 YDL195W SEC31
SGTC_1685 st024049 53.0905 µM 0.682019555584008 0.236490206801803 no 794 0.247613292739718 277 1941139
SGTC_2155 5570423 76 µM 0.681812954300871 0.236558210127883 no 795 0.247678615945426 283 797402
SGTC_3237 9133362 49.47 µM 0.681353263606974 0.236709557060592 no 796 0.247823993990014 282 43845137
SGTC_718 1130-0073 349 µM 0.680240314104972 0.237076201075308 no 797 0.248176154929102 279 6740020
SGTC_1771 st048882 4.1505 µM 0.680069209271061 0.237132596582259 no 798 0.248230319804809 261 4580403
SGTC_2914 7968218 45.32 µM 0.680004730841139 0.237153850341172 no 799 0.248250732705227 249 2977111
SGTC_200 k038-0079 37.545 µM 0.679051528009965 0.237468172724169 no 800 0.248552606768834 293 3436683
SGTC_1688 st021091 57.6 µM 0.67842264114958 0.237675675788287 no 801 0.248751878785893 292 3656366
SGTC_1264 0783-0040 158 µM 0.67797247061393 0.237824271946782 no 802 0.248894574141717 274 2855798
SGTC_740 k014-0057 261 µM 0.677191393960687 0.238082217289914 no 803 0.249142263681975 280 4012779
SGTC_191 3914-0123 66.505 µM 0.676708126132324 0.23824189000953 no 804 0.249295579809504 289 3144412
SGTC_295 k015-0027 31 µM 0.675194507180888 0.238742372334898 no 805 0.249776097979611 279 3887424
SGTC_1070 indatraline 8.81 µM 0.674931235482339 0.238829482543988 no 806 0.249859727209463 285 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2180 6301957 200 µM 0.673527191315467 0.239294340103444 no 807 0.250305977930058 283 845462
SGTC_2453 5731132 22.18 µM 0.672927777289885 0.239492947377977 no 808 0.250496619752011 294 1362040
SGTC_713 1488-1073 324 µM 0.672743059297495 0.239554169182672 no 809 0.250555384256799 292 3312542
SGTC_2430 5571206 200 µM 0.672553462838355 0.239617016760869 no 810 0.250615708347534 289 1731771
SGTC_790 1575-0012 79.1 µM 0.671756266799412 0.239881370359195 no 811 0.250869437150243 286 378741 YLR208W SEC13
SGTC_1611 st001856 99.4 µM 0.670993212730488 0.240134551265566 no 812 0.251112426672771 301 647478
SGTC_360 0957-0399 1.01 µM 0.670398492221173 0.240331980150057 no 813 0.251301897782637 282 6752301 YPR165W RHO1
SGTC_150 3970-0969 77.2 µM 0.670272514042742 0.240373812370719 no 814 0.251342042679397 300 6615640
SGTC_1405 3909-7894 12 µM 0.667268874659479 0.241372372355971 no 815 0.252300202027581 279 7104060
SGTC_248 streptozotocin 5.23457 mM 0.666133070550857 0.241750556861223 no 816 0.252663024075635 299 5300 DNA alkylating agent.
SGTC_2857 9024691 58.44 µM 0.664816973553575 0.24218917473687 no 817 0.25308378245131 304 16478292
SGTC_2605 digitonin 300 nM 0.664659867752338 0.242241562460613 no 818 0.253134034049635 283 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1058 3448-5425 97.3 µM 0.664654644566913 0.242243304263691 no 819 0.253135704819109 286 7279705
SGTC_1314 1222-0010 41.1 µM 0.66457338159219 0.242270404329066 no 820 0.253161699607484 289 3526027
SGTC_1777 st045864 34.765 µM 0.663999925383067 0.24246169065515 no 821 0.253345179421586 305 4691462
SGTC_322 k048-0136 19.3 µM 0.663301714497424 0.242694701484718 no 822 0.253568669369124 280 6823282
SGTC_1539 benzyladenosine 56 µM 0.662368558283624 0.243006308761411 no 823 0.253867524473742 259 92208 A nucleotide analog.
SGTC_2444 5485484 36.41 µM 0.662054657388617 0.243111177778429 no 824 0.253968096753725 304 6790631
SGTC_116 0155-0182 31.788 µM 0.660932335935629 0.243486326614424 no 825 0.254327853881697 249 771486
SGTC_206 4546-0025 72.014 µM 0.660174629530634 0.243739775407064 no 826 0.254570885605062 301 6620745 YIL048W NEO1
SGTC_3058 9093861 49.47 µM 0.65951376825522 0.243960946239921 no 827 0.254782953868493 290 17217477
SGTC_1129 3453-1384 223 µM 0.659242456580147 0.244051777618945 no 828 0.254870043685895 305 1084452
SGTC_1432 4049-0298 68.4 µM 0.657685282265949 0.244573450544516 no 829 0.255370190756628 290 741646
SGTC_3245 9134821 49.47 µM 0.657203473451136 0.244734984124131 no 830 0.255525046236169 301 17014901
SGTC_533 1222-0222 6.71 µM 0.654398881138317 0.245676404690091 no 831 0.256427427531022 299 3982874
SGTC_2405 ticlatone 3.52 µM 0.654206510136761 0.245741049266814 no 832 0.256489383952868 265 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2897 9048598 12.99 µM 0.653842064569695 0.245863543017898 no 833 0.256606781355588 287 6467404
SGTC_1520 flindersine 88 µM 0.653526357978564 0.245969681603434 no 834 0.256708501281637 295 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2254 7938975 95.19 µM 0.652750758148442 0.24623053778339 no 835 0.256958486844776 295 2969277
SGTC_2652 actinonin 100 µM 0.650152562803233 0.247105464103376 no 836 0.257796839680544 285 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2425 5628681 7.85 µM 0.649712482645146 0.24725382290711 no 837 0.257938979640813 296 5714958
SGTC_2747 doxorubicin 7.63 µM 0.647581138209503 0.247973010170427 no 838 0.258627950010201 240 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2568 diosmetin 100 µM 0.647342290278744 0.248053674992033 no 839 0.258705218420326 299 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_635 k038-0028 24.7 µM 0.647298813295579 0.248068359744634 no 840 0.258719284710875 303 4035102
SGTC_486 niguldipine 82 µM 0.644862933149052 0.248891841134942 no 841 0.259508007174692 282 1236 A calcium channel blocker.
SGTC_2986 9022445 71.43 µM 0.644806935888135 0.248910788840897 no 842 0.259526153320712 294 6459286
SGTC_1516 st013856 110 µM 0.644035384768136 0.249171935536804 no 843 0.259776244374447 284 5281404 A mutagen and neurotoxin.
SGTC_2000 st075254 36.4 µM 0.643880239412849 0.249224465133999 no 844 0.259826548298541 265 17234175
SGTC_2159 5658611 73.75 µM 0.642531373795503 0.24968141631489 no 845 0.260264112657982 306 793844
SGTC_1791 st048313 56.1 µM 0.642455024132501 0.249707294361875 no 846 0.260288891405457 272 1204976
SGTC_2120 5538279 151.968 µM 0.642097891248201 0.249828360324466 no 847 0.260404812515867 274 2058197
SGTC_291 SEC14.278 35.5 µM 0.641964662746704 0.249873531987934 no 848 0.260448063720962 289 1068044
SGTC_2388 9080168 200 µM 0.641718716876292 0.249956932320042 no 849 0.260527917129512 308 15943073
SGTC_2753 fluvastatin 17.09 µM 0.641466630854963 0.250042430107632 no 850 0.260609777194864 312 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_102 gallobenzophenone 83.616 µM 0.641119796279165 0.250160088280258 no 851 0.260722426659051 279 70837
SGTC_104 0074-0074 590.992 µM 0.640809472155144 0.250265385742278 no 852 0.260823239016906 280 3943124
SGTC_2328 6201408 200 µM 0.638416541087875 0.251078130526792 no 853 0.261601283118325 311 2890418
SGTC_3179 9107801 49.47 µM 0.637011147846125 0.251556114030579 no 854 0.262058791119847 259 4818259
SGTC_1711 st032263 62.8 µM 0.63567702617194 0.252010302012502 no 855 0.262493476696081 307 3958979
SGTC_2976 9009005 19.48 µM 0.634635455600005 0.252365194529838 no 856 0.262833099205015 273 2993148
SGTC_1048 3161-0300 24.5 µM 0.634116569586206 0.252542091914221 no 857 0.263002374986812 283 2165101
SGTC_2634 4'-methoxyflavone 100 µM 0.633946572618034 0.252600061080272 no 858 0.263057845082112 286 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1079 idarubicin 2.36 µM 0.63360417614453 0.252716839953762 no 859 0.263169587367456 317 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1853 st056710 91.2 µM 0.632847576181832 0.252974989225532 no 860 0.263416592375099 300 269167
SGTC_2522 biochanin a 4.94 µM 0.631361228431368 0.253482529680662 no 861 0.263902180429379 279 5280373 A possible chelator.
SGTC_2342 7990637 118.86 µM 0.630392412951987 0.253813637147589 no 862 0.264218936768437 315 2033102 YER133W GLC7
SGTC_2645 abamectin 100 µM 0.628259660771112 0.254543337035972 no 863 0.264916926401529 280 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2130 NSC 7 2.4545 µM 0.627015064789462 0.254969670387886 no 864 0.265324680112112 283 21448
SGTC_2460 5552655 174.22 µM 0.626291519902062 0.255217690575583 no 865 0.265561873754807 288 5401989
SGTC_1105 epirubicin 18.1 µM 0.625857648113735 0.255366475708091 no 866 0.265704157865965 293 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_963 1269-2853 151 µM 0.625851314122011 0.255368648122773 no 867 0.265706235324301 278 3668223
SGTC_2934 9036370 36.88 µM 0.622956696986765 0.256362445694807 no 868 0.266656489216306 291 6462800
SGTC_2560 caryophyllene 100 µM 0.622084934428403 0.256662138953863 no 869 0.266943010395061 292 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2651 TUB2.036 5 µM 0.621461680813797 0.256876511952303 no 870 0.267147949719264 293 15992207 YFL037W TUB2
SGTC_3105 9121040 49.47 µM 0.620674925440797 0.257147255657898 no 871 0.267406765334442 255 41448907
SGTC_324 1315-0088 19.6 µM 0.620127077924667 0.25733587233583 no 872 0.267587063102421 307 6787421
SGTC_694 1315-0438 43.2 µM 0.618534855095198 0.257884461530568 no 873 0.268111414624732 294 6793154
SGTC_2973 9094665 17.96 µM 0.618464057036087 0.25790886858781 no 874 0.268134741876123 299 25237061 YIL048W NEO1
SGTC_2440 5628896 157.78 µM 0.616131904408197 0.25871352878352 no 875 0.268903733381183 311 5522048
SGTC_189 3970-0742 2.116 µM 0.615801120323698 0.25882776401012 no 876 0.269012893953814 308 2891807
SGTC_1512 0259-0544 12.2 µM 0.614980050253468 0.259111430693662 no 877 0.269283947697212 289 18476
SGTC_2344 7990960 76.95 µM 0.614553461985593 0.259258873597065 no 878 0.269424828150828 301 140813
SGTC_286 k060-0067 22.9 µM 0.614433196669828 0.259300449070369 no 879 0.269464552356138 284 5985051
SGTC_325 2810-4341 181 µM 0.614092920625496 0.259418100462961 no 880 0.269576963052295 298 774970
SGTC_830 4076-0286 57.8 µM 0.613430952951199 0.259647056610133 no 881 0.269795712351647 296 6866659
SGTC_62 0180-0423 3.232 µM 0.612521579143826 0.25996175362605 no 882 0.270096362632848 319 30102 YGL099W LSG1
SGTC_2479 5617353 43.85 µM 0.611989426462709 0.260146001061715 no 883 0.270272376626596 316 2731746
SGTC_961 1252-1571 372 µM 0.61126698131136 0.260396241212205 no 884 0.270511423205871 325 6813498
SGTC_861 0443-0273 110 µM 0.605930640724599 0.2622484726201 no 885 0.27228040583945 315 6149169
SGTC_1005 4092-0690 4.4 µM 0.60236916094077 0.263488398638944 no 886 0.273464216617634 317 1529343
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.601356903273729 0.263841360532942 no 887 0.27380114834284 347 6728940
SGTC_807 1315-0151 48 µM 0.601216543076637 0.263890321444631 no 888 0.273847883679838 320 4011080
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.600327189108739 0.264200656472354 no 889 0.274144100992268 323 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2659 sanguinarine 24.21 µM 0.599073896598988 0.264638301103163 no 890 0.274561803898639 314 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_3101 9120531 49.47 µM 0.597482571519332 0.265194516171062 no 891 0.275092619825792 332 24824904
SGTC_1435 4092-0789 56.7 µM 0.597199227990747 0.26529361531814 no 892 0.275187187284898 308 2248285
SGTC_2608 thymoquinone 42.66 µM 0.597075396567651 0.265336931150657 no 893 0.275228521728215 302 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2368 9071271 200 µM 0.596462110360963 0.265551509589678 no 894 0.275433279300722 317 27209959
SGTC_1270 0831-1170 17.3 µM 0.59617980787496 0.26565031201602 no 895 0.275527556678352 302 6764716
SGTC_988 1497-1057 103 µM 0.59617615655144 0.265651590056813 no 896 0.275528776173651 323 3533044
SGTC_2195 6536160 144.242 µM 0.595288198963132 0.26596248662326 no 897 0.275825421433229 294 3834386
SGTC_1208 2323-2347 50.3 µM 0.594376348288614 0.266281940494151 no 898 0.27613021202917 306 5412760
SGTC_2643 anethole 100 µM 0.593246489328862 0.266678039677123 no 899 0.276508102170261 333 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_3242 9133940 49.47 µM 0.591487522569768 0.26729527993546 no 900 0.277096906484872 306 17248444
SGTC_2297 7971671 152.32 µM 0.590576982872337 0.267615080979814 no 901 0.277401945406466 313 909016
SGTC_115 0527-0192 112.043 µM 0.588807431477741 0.268237136479143 no 902 0.27799523004191 327 4233931
SGTC_509 pifithrin 175 µM 0.588606045826074 0.268307976237523 no 903 0.278062788643194 335 4817 A p53 inhibitor.
SGTC_1382 3002-2117 298 µM 0.587285591446421 0.268772694531288 no 904 0.278505958207194 337 1497314
SGTC_2153 5569715 200 µM 0.585529524036535 0.269391347420086 no 905 0.279095860331645 313 2054701
SGTC_2813 7971799 71.43 µM 0.585384214408321 0.269442571166435 no 906 0.279144700271908 313 2234054
SGTC_430 0958-0115 16.4 µM 0.583896870956438 0.269967161840562 no 907 0.279644849251638 319 6833180
SGTC_245 methotrexate 289.6 µM 0.583460829687194 0.270121051791185 no 908 0.279791559252425 297 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2086 5274770 176.623 µM 0.582914376401975 0.270313970858838 no 909 0.279975471070373 316 689278
SGTC_1722 st034304 3.6505 µM 0.581600532144192 0.270778090229226 no 910 0.280417892201786 324 4036148 YLR033W RSC58
SGTC_3340 9146634 11.102 µM 0.581119816016332 0.270948003972337 no 911 0.280579852067095 303 4907387
SGTC_658 3253-0951 102 µM 0.580777119952045 0.271069165666902 no 912 0.280695338706453 311 1184878
SGTC_2678 equilin 100 µM 0.580361006162233 0.271216320838169 no 913 0.280835597606324 278 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_427 1354-0053 47.3 µM 0.579376214564482 0.271564742755727 no 914 0.281167674875471 324 6813657
SGTC_2156 5649887 115 µM 0.578707319629921 0.271801526635896 no 915 0.281393338108746 319 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_29 0299-0004 12.984 µM 0.577785292359366 0.272128085824438 no 916 0.281704543105551 300 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1210 3013-0140 750 nM 0.576703142696712 0.272511605021262 no 917 0.282070004540741 301 905973
SGTC_383 2324-0395 7.37 µM 0.575998800421687 0.27276137151374 no 918 0.282307996206659 302 3146421
SGTC_2372 9071633 200 µM 0.575883859718822 0.272802141360717 no 919 0.282346842925911 293 21321366
SGTC_275 trichlorophene 5.69 µM 0.574089574526719 0.273438971903651 no 920 0.282953593939124 301 62616
SGTC_499 genistein 192 µM 0.572708280149072 0.273929723969996 no 921 0.283421115067391 336 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2309 7664088 163.95 µM 0.570230234644871 0.274811224109279 no 922 0.284260776004217 310 704922
SGTC_194 1486-1323 56.904 µM 0.569980209816576 0.274900241528366 no 923 0.284345560416539 316 5178754
SGTC_213 1246-0773 967 nM 0.569797837744676 0.274965181205935 no 924 0.284407411132063 327 6251622
SGTC_3009 9080819 71.4286 µM 0.569485373191222 0.275076462229986 no 925 0.284513397101178 307 17027216
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.567615594001473 0.275742827920775 no 926 0.285148008070583 330 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_156 3474-0145 5.642 µM 0.565838731279604 0.276376813708905 no 927 0.285751707301277 292 2265471
SGTC_832 4083-0019 164 µM 0.565497307033937 0.276498715944825 no 928 0.285867777728224 315 1990758
SGTC_3060 1327-0027 12.5 µM 0.564615413736992 0.276813709383747 no 929 0.286167689449728 291 16000455 YPR107C YTH1
SGTC_534 k292-0788 63.4 µM 0.564541435655897 0.276840140761868 no 930 0.286192854494409 350 4146317
SGTC_249 wiskostatin 11.211 µM 0.56048029351687 0.278293025912935 no 931 0.287575938800575 307 2775510 A n-wasp and actin depolymerizer.
SGTC_2394 5221648 200 µM 0.559405025844005 0.278678327420011 no 932 0.287942666074962 321 788586
SGTC_235 0330-0087 5 mM 0.558645939355515 0.278950487784567 no 933 0.288201690516644 313 46494818 YHR062C RPP1
SGTC_3342 9147791 14.508 µM 0.557663731022122 0.279302837296742 no 934 0.288537014261288 307 1838168
SGTC_8 0354-0001 70 µM 0.557398266011941 0.279398105187151 no 935 0.28862767497349 320 4993152
SGTC_2950 9072895 21.46 µM 0.555881400547397 0.27994276790933 no 936 0.289145966946976 290 17332245
SGTC_1692 fluoroquinolonic acid 71 µM 0.555571729861178 0.280054024987675 no 937 0.289251830908361 326 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2738 aclarubicin 5.55 µM 0.5544982081373 0.280439880848767 no 938 0.289618965816925 280 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2050 5263056 171 µM 0.55415341821785 0.280563863254075 no 939 0.289736927306565 313 763468 YGL055W OLE1
SGTC_2146 5545642 200 µM 0.553600417180874 0.280762771301396 no 940 0.28992617023298 324 825326
SGTC_420 mitomycin C 81.9 mM 0.553324311226003 0.28086210892333 no 941 0.290020678362438 313 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.55145158778224 0.281536326953091 no 942 0.290662072520595 349 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1359 1582-0056 520 nM 0.551048201161732 0.281681656362391 no 943 0.29080031630733 331 3661189
SGTC_2855 9016525 58.44 µM 0.549984435971207 0.282065075871083 no 944 0.291165024399226 329 43811474
SGTC_2124 5246320 200 µM 0.545338153656708 0.283742703942847 no 945 0.292760483907546 329 579342
SGTC_95 0471-0001 561.058 µM 0.544702429230308 0.283972615347525 no 946 0.29297909691415 298 4015405
SGTC_1296 1068-0102 11.9 µM 0.544638580798842 0.283995711225173 no 947 0.293001057306947 333 767053
SGTC_737 1950-0117 57.9 µM 0.54424399635728 0.284138464096092 no 948 0.293136789865482 316 5393513
SGTC_2927 9011802 47.9 µM 0.543866777361013 0.284274966567279 no 949 0.293266576164143 317 43912568
SGTC_112 phenothiazine 287.218 µM 0.543524038086863 0.284399019196538 no 950 0.293384522429167 344 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_555 4296-0685 37 µM 0.539028663550905 0.286028485525497 no 951 0.294933538311621 349 2908540 YHR072W ERG7
SGTC_2528 xanthyletin 44.79 µM 0.538870140093061 0.286086027400024 no 952 0.294988231042974 351 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1117 retinoic acid 1.10837 µM 0.538751533068777 0.286129083744901 no 953 0.295029155122 333 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.537446524416746 0.286603026989118 no 954 0.295479606924057 309 115019
SGTC_2620 irigenin 100 µM 0.536354932650144 0.28699974885109 no 955 0.295856636065081 329 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_3068 9116768 49.47 µM 0.53499538305709 0.287494219187384 no 956 0.296326524933611 335 41904888
SGTC_2493 resveratrol 26.09 µM 0.534734505897123 0.28758914666925 no 957 0.296416728670525 303 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_3147 9097027 49.47 µM 0.534011587125592 0.287852278358218 no 958 0.296666758703231 358 25236841
SGTC_3084 9116877 49.47 µM 0.531115601338264 0.288907512623199 no 959 0.297669336813186 319 27241325
SGTC_469 w7 172 µM 0.531059382951803 0.288928015381226 no 960 0.297688814671885 330 45115570 A P450 inhibitor.
SGTC_1944 st076371 56.9 µM 0.530697818678892 0.289059893667573 no 961 0.297814098932366 314 24208455
SGTC_1347 1493-0251 600 nM 0.529459567508035 0.289511752343198 no 962 0.298243342720171 309 3986378
SGTC_48 0382-0018 55 µM 0.527629972963158 0.290180008655716 no 963 0.2988780927327 294 762596
SGTC_2393 9031399 185.94 µM 0.527335300747683 0.290287704720267 no 964 0.298980382138009 350 1526623 YDL150W RPC53
SGTC_309 k408-0051 1.48 µM 0.526586471327173 0.290561469223778 no 965 0.299240394396206 347 3640463
SGTC_1710 st031758 61.5 µM 0.52550343350429 0.290957630534852 no 966 0.299616633537776 335 5394341
SGTC_2215 7188065 200 µM 0.525232222727516 0.291056875451503 no 967 0.299710883655917 339 940217
SGTC_2798 7813637 45.45 µM 0.524970017039887 0.291152840142168 no 968 0.299802017125867 344 956368
SGTC_893 0958-0369 48.9 µM 0.524581566584011 0.291295036322287 no 969 0.29993705189324 350 6819948
SGTC_1450 4112-4260 37.6 µM 0.524161320890359 0.291448907958985 no 970 0.300083170443613 337 1633175
SGTC_892 0929-0076 29 µM 0.524028427025193 0.291497574518634 no 971 0.300129384063214 318 5751038
SGTC_1521 st012942 49.4 µM 0.523400914833349 0.291727424570718 no 972 0.300347643848005 304 24207259
SGTC_1916 st067606 49.2 µM 0.521864670473281 0.292290488322901 no 973 0.300882279166599 333 19590279
SGTC_2348 9022543 33.42 µM 0.520544335122549 0.292774820707251 no 974 0.301342117686391 334 3162678 YDL140C RPO21
SGTC_1553 gossypol 38.6 µM 0.519701777360278 0.293084086839033 no 975 0.301635723961305 338 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_411 enrofloxacin 100 µM 0.519616174631298 0.293115516337267 no 976 0.301665561160321 343 71188 A bacterial gyrase inhibitor.
SGTC_3128 9127691 49.47 µM 0.518209057568719 0.293632370740515 no 977 0.302156207954456 349 41316314
SGTC_2266 7929956 200 µM 0.518143245485682 0.293656554792857 no 978 0.302179164696376 330 2967153
SGTC_2715 st079500 56.4 µM 0.517435585397811 0.293916657811054 no 979 0.302426061978597 323 28246688
SGTC_1393 3470-5649 58.2 µM 0.517117024148746 0.294033780913667 no 980 0.302537235122084 317 4108395
SGTC_2866 9034245 58.44 µM 0.513419780586937 0.295394695133468 no 981 0.303828855896378 342 6462273
SGTC_2497 7-hydroxyflavone 100 µM 0.511622369412525 0.296057347336326 no 982 0.304457663361825 364 5281894
SGTC_3314 9135860 59.4275 µM 0.51128910868717 0.296180285621362 no 983 0.30457431512571 341 25252478
SGTC_2594 a-mangostin 100 µM 0.508628825137491 0.297162490022225 no 984 0.305506210145241 349 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2902 5787006 60.46 µM 0.508066841477153 0.297370170598228 no 985 0.305703234130234 330 591003
SGTC_716 1683-5115 658 µM 0.507299771726288 0.297653747522705 no 986 0.305972249365797 349 723597
SGTC_41 0478-0632 82.643 µM 0.507273557111552 0.297663440946726 no 987 0.305981444814509 367 3750424
SGTC_279 1273-0055 2.93 µM 0.507222462894342 0.297682334558935 no 988 0.305999367773561 349 2847562
SGTC_2253 7938677 135.83 µM 0.505147461642645 0.298450090111697 no 989 0.306727634061345 318 2301972
SGTC_3228 9131799 49.47 µM 0.498894186287658 0.300769247789572 no 990 0.308926964960904 345 17015818
SGTC_2049 5262831 67.185 µM 0.498343431277474 0.300973895835105 no 991 0.30912100047055 354 763417
SGTC_3139 9095020 49.47 µM 0.497964142865545 0.301114867283195 no 992 0.309254657864131 304 25236292
SGTC_2954 9074818 52.69 µM 0.49776656744032 0.301188312615634 no 993 0.309324291444041 356 16648742
SGTC_1163 k060-0048 49.9 µM 0.496457834737638 0.301675015566114 no 994 0.309785714672662 327 6809982
SGTC_798 1287-0182 476 µM 0.494270018116418 0.302489428683287 no 995 0.310557748182324 362 1649755
SGTC_185 k048-0037 25.491 µM 0.493601076711324 0.302738638255256 no 996 0.310793970116147 329 6827589
SGTC_153 4077-0274 519.67 µM 0.493600709396101 0.302738775121304 no 997 0.31079409984687 337 3121976
SGTC_2465 5809242 33.21 µM 0.492778184024179 0.303045327410261 no 998 0.311084663555706 360 2731748
SGTC_181 1447-1644 8.07 µM 0.491292059743596 0.303599552494806 no 999 0.311609947505198 358 534600
SGTC_1317 1273-0028 910 nM 0.490859566598205 0.303760928522589 no 1000 0.311762888197034 334 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_845 0330-0138 4.51 µM 0.490626085952619 0.30384806298631 no 1001 0.311845466452073 366 9039800
SGTC_3030 9087619 49.47 µM 0.489787787581091 0.304161005932819 no 1002 0.312142036699684 331 25236973
SGTC_1708 st033234 31.827 µM 0.48911475735 0.304412356944209 no 1003 0.312380227117089 316 674664
SGTC_1396 3511-0007 98.6 µM 0.489056572177305 0.304434091218918 no 1004 0.312400822967735 343 X1396
SGTC_2685 mycophenolic acid 18.85 µM 0.48851455803537 0.304636586355596 no 1005 0.312592708284755 332 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2071 5230951 39.92 µM 0.488284224919346 0.304722656368727 no 1006 0.312674266827148 358 1799272
SGTC_3156 9099931 49.47 µM 0.488276798835261 0.304725431499818 no 1007 0.312676896478355 342 18111053
SGTC_1560 lithocholic acid 53.1 µM 0.488104975662536 0.304789645037202 no 1008 0.312737743457694 341 9903 A bile acid which acts as a detergent.
SGTC_2280 7785178 200 µM 0.486337719722797 0.305450450416909 no 1009 0.313363869910997 333 2954328
SGTC_2786 7743617 45.45 µM 0.485707431146357 0.305686279019058 no 1010 0.31358730708069 325 583674
SGTC_3292 9120825 59.784 µM 0.483628588150253 0.30646466939637 no 1011 0.314324741053118 359 24824900
SGTC_3061 glucosamine 200 µM 0.483522416451309 0.306504447223218 no 1012 0.314362423576577 332 91431 and experimental redox chemotherapeutic
SGTC_3324 9138759 60.749 µM 0.482558596707078 0.306865651978145 no 1013 0.314704591513931 360 45595710
SGTC_921 1561-0023 372 µM 0.480343507545439 0.307696497761309 no 1014 0.315491578480342 322 24050882
SGTC_475 α-linolenic acid 10 µM 0.480325937997342 0.30770309177942 no 1015 0.315497824022319 332 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_7 0192-1582 4.227 µM 0.480033594776255 0.307812820078864 no 1016 0.315601752576779 355 252616
SGTC_767 0929-0023 86 µM 0.480010296156881 0.307821565737889 no 1017 0.315610035906578 354 1204563
SGTC_2606 farnesol 9.78 µM 0.479966676337 0.307837939708575 no 1018 0.31562554425714 344 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2207 7258803 200 µM 0.479911918906681 0.307858495047642 no 1019 0.31564501287201 363 3666799
SGTC_2774 tamoxifen 10.92 µM 0.479706433640375 0.307935637340622 no 1020 0.315718076258844 335 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_3208 9114115 49.47 µM 0.47936600167915 0.308063459354158 no 1021 0.315839137828521 368 650895
SGTC_2872 9044037 25.97 µM 0.478324036945018 0.308454830583948 no 1022 0.316209795357205 365 6465195
SGTC_1804 st050076 49.1 µM 0.477974019592218 0.308586349101757 no 1023 0.316334348309973 335 3895976
SGTC_877 0771-0151 33.1 µM 0.475800828377047 0.309403471703957 no 1024 0.31710813982704 352 6166523
SGTC_220 paclitaxel 373.376 µM 0.475780866704293 0.309410981695932 no 1025 0.317115251141305 355 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2988 9073640 71.4286 µM 0.473991545931181 0.310084484049477 no 1026 0.317752967929706 358 9102229
SGTC_2227 7312221 64.1025 µM 0.472824768028468 0.31052400420695 no 1027 0.31816910099628 362 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1939 st074455 53.6 µM 0.47269353955866 0.310573454342803 no 1028 0.318215918198582 370 1644229
SGTC_996 3970-0799 1.8 µM 0.472345000123712 0.310704809247145 no 1029 0.318340277580206 360 6615648 YGL040C HEM2
SGTC_1799 st045822 46.1415 µM 0.470306335709233 0.31147360863402 no 1030 0.319068085788338 362 3674992
SGTC_1855 st056195 39.6 µM 0.470165924415833 0.311526589366078 no 1031 0.319118238690522 342 4028379
SGTC_531 3788-1495 174 µM 0.468169075302335 0.312280473019817 no 1032 0.319831842585698 353 2896655
SGTC_3110 9122132 49.47 µM 0.467149745617574 0.312665610762095 no 1033 0.3201963727449 332 918317
SGTC_1596 piperlongumine 63 µM 0.464036741531258 0.31384307597797 no 1034 0.321310711094597 327 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1108 betulinic acid 729.144 nM 0.46402893088485 0.31384603267555 no 1035 0.321313509041663 322 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_3111 9122088 49.47 µM 0.463040465270025 0.314220309898864 no 1036 0.321667681187805 347 16876704
SGTC_1162 k048-0130 20.1 µM 0.460883263904438 0.315037785939603 no 1037 0.322441179840832 365 6797406
SGTC_2228 7354201 200 µM 0.45956222457733 0.315538844586863 no 1038 0.322915239414723 382 753451
SGTC_157 1348-1695 65.819 µM 0.459517231629537 0.315555915998276 no 1039 0.322931390364339 352 5380510
SGTC_1975 st070967 30.8 µM 0.457498311413234 0.316322347768413 no 1040 0.323656457858185 377 261391
SGTC_1783 st039459 87.517 µM 0.456426272970892 0.31672964115159 no 1041 0.324041738250927 414 729761
SGTC_2692 st077426 47.7 µM 0.456382331010644 0.316746340512374 no 1042 0.324057534597775 359 25238571
SGTC_1126 isoteolin 1.0172 µM 0.45622012763298 0.316807986255593 no 1043 0.324115846546545 337 133323
SGTC_2736 butenafine 14.65 µM 0.456214744756226 0.31681003211672 no 1044 0.324117781759232 357 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3149 9097855 49.47 µM 0.456146116746847 0.316836115942537 no 1045 0.324142454818373 337 25236625 YMR079W SEC14
SGTC_1328 1441-0025 69.2 µM 0.455938863941796 0.316914893184958 no 1046 0.32421697078484 348 4562601
SGTC_2411 st077133 39.94 µM 0.455870319002494 0.316940949092452 no 1047 0.324241617078899 383 1403142 YNL221C POP1
SGTC_2407 paclitaxel 400 µM 0.455784086426165 0.316973729870192 no 1048 0.324272624304744 408 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2832 7992762 51.95 µM 0.45542619722743 0.317109794575875 no 1049 0.324401325947364 309 2985177
SGTC_142 0335-0849 62.6745 µM 0.453926288232294 0.317680308830977 no 1050 0.324940940916395 330 3889043 YPR107C YTH1
SGTC_460 trequinsin 123 µM 0.452909814774839 0.318067187047757 no 1051 0.325306841617782 360 5537 A vasodilator.
SGTC_1807 st050092 58.9 µM 0.452852471426257 0.318089018323097 no 1052 0.325327488568825 360 5008496
SGTC_3189 9110682 49.47 µM 0.452687563746686 0.318151804104276 no 1053 0.325386867942471 356 17122418
SGTC_1 0258-0098 57.368 µM 0.452123155530661 0.318366732429143 no 1054 0.325590131597278 322 6790032 YDR047W HEM12
SGTC_2446 5162541 200 µM 0.452065431875759 0.318388717216405 no 1055 0.325610922881989 346 1549321
SGTC_2427 5545055 42.75 µM 0.451054537122608 0.318773832946533 no 1056 0.325975121486259 354 5372858
SGTC_2379 9035213 200 µM 0.450658785764237 0.318924653797767 no 1057 0.326117745476475 370 646551
SGTC_1725 st036284 20.55 µM 0.448839792831202 0.319618257414595 no 1058 0.326773615371575 355 707914
SGTC_929 2805-0021 398 µM 0.448507229704467 0.319745136029612 no 1059 0.32689358483035 376 3098024
SGTC_2270 7924575 90.91 µM 0.448417155000985 0.319779504726424 no 1060 0.326926081631627 365 1262135
SGTC_2499 avocadenofuran 51.48 µM 0.446478997390645 0.320519398138539 no 1061 0.327625640232939 359 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_794 k038-0031 316 µM 0.446377249647795 0.320558260176561 no 1062 0.327662381812525 355 6624242
SGTC_2980 9014342 25.29 µM 0.446342833892029 0.320571405546436 no 1063 0.32767480987849 380 2996599
SGTC_1483 3453-0561 55.9 µM 0.446208171378683 0.320622843120567 no 1064 0.327723440446345 360 4546991
SGTC_1624 st003710 6.25 µM 0.445219226970954 0.321000699627559 no 1065 0.328080666649275 395 24207033
SGTC_842 0271-0008 11.1 µM 0.444748216953451 0.321180728654208 no 1066 0.328250860071038 340 1221709
SGTC_2827 7993847 71.43 µM 0.442541901715906 0.322024583502986 no 1067 0.32904855794701 364 2985692
SGTC_454 lyso-paf C-16 6.67 µM 0.442298898793304 0.322117581659509 no 1068 0.329136463856311 372 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1509 1326-1131 80 µM 0.440236139536447 0.322907455681596 no 1069 0.329883043740501 346 768313
SGTC_709 3807-1509 243 µM 0.440084026037582 0.322965734841882 no 1070 0.329938125463881 381 1886677 YPL242C IQG1
SGTC_2419 paclitaxel 166.5 µM 0.440077234142481 0.322968337118268 no 1071 0.329940584958749 377 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2905 7799065 20.05 µM 0.438053176609066 0.32374422901574 no 1072 0.330673867918683 375 1296806
SGTC_1024 4507-0395 26 µM 0.435226267824955 0.324829164533631 no 1073 0.331699098849957 343 4201836
SGTC_2486 5283202 22.39 µM 0.434848807602293 0.324974142256429 no 1074 0.331836087465627 358 1377751
SGTC_347 4534-1311 26.2 µM 0.433543358134661 0.325475753237129 no 1075 0.332310037057644 351 2862016
SGTC_3046 9092212 49.47 µM 0.433130761301197 0.325634356869937 no 1076 0.332459888120028 383 25236637
SGTC_896 0964-0007 44.5 µM 0.433111077875081 0.325641924035421 no 1077 0.332467037613914 361 6756758
SGTC_99 0109-0120 622.8 µM 0.433059897830653 0.325661600207791 no 1078 0.332485627722553 379 759414
SGTC_3344 9148862 3.898 µM 0.432387413877934 0.32592018182386 no 1079 0.332729932081175 370 4905352
SGTC_3222 9128301 49.47 µM 0.432208648066519 0.325988934440909 no 1080 0.332794887248928 342 4911358
SGTC_3295 9122362 53.5725 µM 0.43059636727323 0.32660927826488 no 1081 0.33338094152942 372 4730473
SGTC_2143 5623677 140.463 µM 0.430266504103391 0.326736256135134 no 1082 0.333500894983433 355 5375313
SGTC_201 4262-0159 12.803 µM 0.42951799536711 0.327024462289397 no 1083 0.333773150398069 372 1341029
SGTC_2995 9067767 71.4286 µM 0.427778990450515 0.327694447709475 no 1084 0.334406017177088 358 11673567
SGTC_2978 9011784 42.97 µM 0.427617777068637 0.327756586444592 no 1085 0.334464710581111 366 2994934
SGTC_2240 6690706 185.951 µM 0.427267372411789 0.327891664275774 no 1086 0.334592297332251 333 805876
SGTC_3236 9132701 49.47 µM 0.427051466378404 0.327974905315706 no 1087 0.334670920952222 393 24282524
SGTC_586 0957-0265 8.15 µM 0.4267644021068 0.328085594144312 no 1088 0.334775468545457 393 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2853 9015042 58.44 µM 0.425849237362187 0.328438572371513 no 1089 0.335108853147225 331 6457456
SGTC_1266 0828-0227 32.9 µM 0.424885252960988 0.328810545958349 no 1090 0.335460162752718 353 3913820
SGTC_593 1203-0218 61.7 µM 0.424250712514437 0.329055489301767 no 1091 0.335691490031187 377 3666956
SGTC_618 k072-0232 33.2 µM 0.423482282256715 0.329352214659255 no 1092 0.33597171138789 379 5872756 YGL099W LSG1
SGTC_2212 7123476 200 µM 0.41880709990651 0.331159823046541 no 1093 0.337678557791682 368 1085715
SGTC_3225 9130819 49.47 µM 0.41857691858046 0.331248922302354 no 1094 0.337762680566618 369 4547121
SGTC_2783 7738165 71.43 µM 0.418310756775926 0.331351960897285 no 1095 0.337859962982604 360 17201110
SGTC_225 nsc-122657 1.016 µM 0.418140161027983 0.331418009943856 no 1096 0.337922321602279 372 275685
SGTC_2031 5180455 200 µM 0.417777249528785 0.331558534745732 no 1097 0.338054993045917 364 29949
SGTC_612 0302-0167 22.4 µM 0.416866231303774 0.331911399170589 no 1098 0.33838812731637 379 235821
SGTC_816 0325-0417 81.3 µM 0.416833054194937 0.331924252467043 no 1099 0.338400261660618 370 68101
SGTC_34 0469-0683 81.75 µM 0.416826018599596 0.331926978184842 no 1100 0.338402834912308 358 3690923
SGTC_1093 fluphenazine 7.97 µM 0.415423760149813 0.332470416051103 no 1101 0.338915857990824 386 6602611 An atypical antipsychotic.
SGTC_1464 k208-0027 110 µM 0.414562670040459 0.332804301669667 no 1102 0.339231040199713 399 X1464
SGTC_1071 trifluoperazine 6.31 µM 0.414518924448664 0.332821267460066 no 1103 0.339247055271718 399 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_973 1325-0077 65.9 µM 0.413825228346741 0.333090348361441 no 1104 0.339501053214289 393 2835149
SGTC_726 3448-4391 34.2 µM 0.413508325392956 0.333213301884371 no 1105 0.339617112013185 391 1356692
SGTC_1922 5578187 25 µM 0.412012098447302 0.333794057113004 no 1106 0.340165277783514 334 1350412
SGTC_1748 st037455 53.6035 µM 0.411067973309382 0.334160721066334 no 1107 0.340511346567898 382 580690
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.409139005074532 0.334910354248514 no 1108 0.341218826629415 354 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.408892471616841 0.335006209269509 no 1109 0.341309287034568 377 4620898
SGTC_511 blebbistatin 171 µM 0.408874577865899 0.335013166982463 no 1110 0.341315853135172 376 3476986 A myosin inhibitor.
SGTC_2515 chrysin 20.77 µM 0.408638392234778 0.335105009478818 no 1111 0.341402525804481 354 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_192 3455-0609 60.9 µM 0.40831624576921 0.335230294364157 no 1112 0.341520756871794 342 3769639
SGTC_403 arphamenine a 50 µM 0.407332912830788 0.335612832353833 no 1113 0.341881746327208 394 5487158 An arginine aminopeptidase inhibitor.
SGTC_2296 7971656 126.45 µM 0.406492001984775 0.335940100259906 no 1114 0.342190566212999 364 666570
SGTC_732 3970-1727 52.7 µM 0.406449903959529 0.335956487353168 no 1115 0.342206029257978 396 1275699
SGTC_3211 9128781 49.47 µM 0.406212884264962 0.336048755548863 no 1116 0.342293094008529 383 17194361
SGTC_515 4092-1064 102 µM 0.405665536013082 0.336261867720478 no 1117 0.342494184174212 397 717353
SGTC_1986 st071812 45 µM 0.40515001638721 0.336462635421558 no 1118 0.342683621663695 380 11838594
SGTC_357 1325-0123 420 µM 0.404828467955027 0.336587885194084 no 1119 0.342801800790454 393 1098503
SGTC_1634 st006576 41 µM 0.404053297648768 0.336889904599422 no 1120 0.343086763402892 395 3915356
SGTC_1437 4092-1038 11.6 µM 0.402522244132385 0.337486737775667 no 1121 0.343649860581713 375 3977136
SGTC_3345 9148410 3.559 µM 0.401614227379653 0.337840892961767 no 1122 0.343983978785349 381 4903596
SGTC_650 1328-0195 38 µM 0.400547783077687 0.338257023263653 no 1123 0.344376548348365 394 2780821
SGTC_2046 4110841 106 µM 0.400245272132035 0.338375100100856 no 1124 0.344487936418869 385 44119630 YMR134W ERG29
SGTC_585 0kpi-0023 191 µM 0.398819437451258 0.338931849342482 no 1125 0.345013126893948 373 64601
SGTC_3136 9095672 49.47 µM 0.398766236610908 0.338952629627377 no 1126 0.345032728623319 350 17217380
SGTC_1219 1469-0211 33.1 µM 0.397795328044907 0.33933195320644 no 1127 0.345390530688177 414 6822282
SGTC_938 3126-1755 342 µM 0.397671425794297 0.339380372215143 no 1128 0.345436201458759 369 1777771
SGTC_769 0302-0231 76 µM 0.397659204650206 0.339385148185582 no 1129 0.345440706333964 382 571869 YER009W NTF2
SGTC_2846 9008642 19.48 µM 0.397063040548297 0.339618157859805 no 1130 0.345660486871408 403 2992898
SGTC_1680 diphenhydramine 100 µM 0.396929670077087 0.339670293865786 no 1131 0.345709662058399 393 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1413 3910-0535 34.4 µM 0.395985403706267 0.340039505829358 no 1132 0.346057898070301 383 2876951
SGTC_85 0868-0259 160.055 µM 0.395245748810801 0.340328821084209 no 1133 0.346330766387824 386 83173
SGTC_1320 1313-0481 95.3 µM 0.394504950062171 0.340618677988687 no 1134 0.346604136656241 369 6813365 YLR208W SEC13
SGTC_1124 fisetin 1.16336 µM 0.39398962016586 0.340820369841521 no 1135 0.346794351324531 372 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2373 9071805 200 µM 0.393593036180907 0.340975617442346 no 1136 0.34694076170306 380 10149009
SGTC_2716 st080858 38.6235 µM 0.392392338053763 0.341445809360367 no 1137 0.347384173201452 360 5296050
SGTC_2063 5246145 200 µM 0.3920632099707 0.341574738538556 no 1138 0.34750575498292 388 711240
SGTC_51 1013-0126 23.419 µM 0.389684761877905 0.342506995516917 no 1139 0.348384832887841 401 1627850
SGTC_3086 9117350 49.47 µM 0.388264521151438 0.343064131650634 no 1140 0.348910144913958 364 2679265
SGTC_1698 5-fluorocytosine 1.055 µM 0.387929177544721 0.3431957310689 no 1141 0.349034222563851 385 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1966 st070145 16.1 µM 0.386720071918973 0.343670380096108 no 1142 0.349481727445141 377 3748532
SGTC_3205 9113483 49.47 µM 0.386681510845451 0.343685521772553 no 1143 0.349496002820148 426 17018033
SGTC_1431 4049-0260 9.09 µM 0.386385110795839 0.343801916779745 no 1144 0.349605737727525 373 3854841
SGTC_2011 4012611 177 µM 0.385838131994635 0.344016751838378 no 1145 0.349808276312426 391 2049887
SGTC_646 4092-0839 27.3 µM 0.384610498188552 0.344499108792938 no 1146 0.350263007472602 404 877796
SGTC_1859 st055998 20 µM 0.383430792430395 0.344962872440957 no 1147 0.350700187826113 373 676301
SGTC_1600 coumarin 106 71.1 µM 0.382574377973411 0.345299690454602 no 1148 0.351017685467076 410 100336 A hepatotoxic, DNA x-linker.
SGTC_372 0155-0182 15.9 µM 0.380383118328254 0.346162045259518 no 1149 0.351830522075817 368 771486
SGTC_3348 9149464 3.537 µM 0.379573447792145 0.346480887623728 no 1150 0.352131036909172 354 1951442
SGTC_31 0508-1974 57.237 µM 0.378982303951013 0.346713744498434 no 1151 0.352350502393767 366 6810525
SGTC_2884 9058502 51.95 µM 0.37896382254524 0.346721025424508 no 1152 0.352357364512922 380 6471554
SGTC_1556 plumbagin 1.48 µM 0.378066814973775 0.347074478122183 no 1153 0.352690479860027 388 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2612 dictamnine 15.46 µM 0.377463091759562 0.347312441361268 no 1154 0.352914743901012 385 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_399 oxolinic acid 75 µM 0.377420475059732 0.347329241414136 no 1155 0.352930576586549 377 4628 A DNA gyrase inhibitor.
SGTC_1683 st010134 710 nM 0.375662240217366 0.348022621402112 no 1156 0.35358400652234 375 3818134
SGTC_3221 9128209 49.47 µM 0.375524250988723 0.348077060577308 no 1157 0.353635307096886 386 16460723
SGTC_2610 ononetin 44.17 µM 0.374816338632374 0.348356393653251 no 1158 0.353898531093901 369 259632
SGTC_1693 xanthone 101.9 µM 0.374495530248571 0.348483007597321 no 1159 0.354017840710954 411 7020 An insecticide.
SGTC_2053 5265679 138 µM 0.374189370360986 0.348603855941334 no 1160 0.354131715875702 376 764595
SGTC_78 0336-0123 156.75 µM 0.374143181244635 0.34862208918133 no 1161 0.354148896898676 367 6765896
SGTC_3079 9117512 49.47 µM 0.37376357841207 0.34877195135214 no 1162 0.354290109480172 428 7185044
SGTC_1462 k081-0014 26.5 µM 0.373235492178614 0.348980472048469 no 1163 0.354486591337254 360 3270634
SGTC_1175 0741-0056 27.6 µM 0.367816903802247 0.35112268685944 no 1164 0.35650488193425 387 765927
SGTC_98 0074-0023 107.663 µM 0.367112633799664 0.351401466352128 no 1165 0.356767501923578 385 3563821
SGTC_1832 st054113 55 µM 0.365909568769259 0.351877874650768 no 1166 0.357216277975384 398 1251267
SGTC_2944 9067346 25.62 µM 0.365431657623874 0.352067189906108 no 1167 0.3573946067307 387 6473075
SGTC_2945 9067681 61.76 µM 0.364234022623287 0.352541770855861 no 1168 0.35784163148537 421 16456930
SGTC_2848 9016370 25.97 µM 0.363837257758915 0.352699045597231 no 1169 0.357989769491255 389 7894410
SGTC_3017 9080681 49.47 µM 0.363622026168414 0.352784372389203 no 1170 0.358070138324307 412 16451914
SGTC_2201 6605497 169.863 µM 0.363603165992776 0.352791849703517 no 1171 0.358077181132605 388 670741
SGTC_819 1013-0258 27.7 µM 0.363078014402235 0.353000074381762 no 1172 0.358273303782714 382 5753198
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.362861389502069 0.353085979840252 no 1173 0.358354215224881 401 689007
SGTC_1472 k841-0093 193 µM 0.362666913504575 0.353163108238536 no 1174 0.358426859261277 395 X1472
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.362010645366692 0.35342342605047 no 1175 0.358672037685559 394 688751
SGTC_1608 st001473 40.5 µM 0.36147969206764 0.353634086197832 no 1176 0.358870441762028 422 7292267
SGTC_2045 5106652 78.05 µM 0.361329459581152 0.353693700329319 no 1177 0.358926586829761 412 673349
SGTC_2484 5809818 12.04 µM 0.359847507269259 0.354281949622101 no 1178 0.35948058699617 367 2870548
SGTC_484 loperamide 105 µM 0.359522818507616 0.354410878770784 no 1179 0.359602005322051 375 3955 An opioid-receptor agonist.
SGTC_3144 9087057 49.47 µM 0.358035782610319 0.355001571934844 no 1180 0.360158267752544 424 17249618
SGTC_1113 artemisinin 1.17947 µM 0.357684892378101 0.355141006462784 no 1181 0.360289570131232 400 2240 An anti-malaria and mitochondrial poison.
SGTC_2232 chlorophetanol 41.5365 µM 0.356919659172898 0.355445157227659 no 1182 0.360575975911719 400 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2134 5324836 1.464 µM 0.356302488119916 0.355690526076448 no 1183 0.360807023094207 397 699272
SGTC_1407 3909-7909 12.3 µM 0.356225486015586 0.355721144020651 no 1184 0.360835853546586 390 4411780
SGTC_1197 1601-0112 267 µM 0.356104130279773 0.355769399956926 no 1185 0.360881292101813 379 7350313
SGTC_2868 9035608 32.47 µM 0.35361112926176 0.356761228169792 no 1186 0.361815166324191 383 6462614
SGTC_3354 9151612 71.43 µM 0.353429155361129 0.356833663626311 no 1187 0.361883365773744 406 27261949
SGTC_77 0828-0286 12.516 µM 0.353339064897 0.356869526415241 no 1188 0.361917131140478 358 745345
SGTC_423 5-fluorouracil 457 µM 0.352403307141502 0.357242103223741 no 1189 0.362267911065521 376 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3070 9117005 49.47 µM 0.352279801647094 0.357291287755601 no 1190 0.362314217217528 390 8779016
SGTC_3299 9121982 43.1275 µM 0.352219517657989 0.357315295967997 no 1191 0.362336820340993 374 17594604 YPL160W CDC60
SGTC_1364 1653-0028 37.6 µM 0.351870414962662 0.357454337878481 no 1192 0.362467723756892 388 5718652
SGTC_1136 pergolide 1.05886 µM 0.351831277004783 0.357469927068917 no 1193 0.362482400362101 399 47811 A dopamine receptor agonist.
SGTC_746 1095-0025 46.6 µM 0.35039745788174 0.358041200840325 no 1194 0.363020216968005 419 6749286
SGTC_237 nikkomycin 200 µM 0.350093120904655 0.358162498188608 no 1195 0.363134406673289 403 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2575 plumbagin 510 nM 0.349945481230595 0.358221347004825 no 1196 0.363189806661499 386 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_228 caffeine 993.056 µM 0.34992313707588 0.35823025362422 no 1197 0.363198191282623 373 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1280 0880-0253 10.1 µM 0.349879937469372 0.358247473668828 no 1198 0.363214402076522 401 6836607
SGTC_2125 5246583 200 µM 0.349432906817291 0.358425684061692 no 1199 0.363382166175162 422 835267
SGTC_3209 9113616 49.47 µM 0.34890809040255 0.358634943384164 no 1200 0.363579155581705 421 16649353
SGTC_3003 9075612 71.4286 µM 0.348552059488716 0.358776927267015 no 1201 0.363712812030564 414 6501993
SGTC_3094 9117742 49.47 µM 0.348244219399662 0.358899708551822 no 1202 0.363828390684922 399 17149698
SGTC_1495 4469-0029 237 µM 0.347899377735208 0.359037265140156 no 1203 0.363957876306156 392 793680
SGTC_3167 9103034 49.47 µM 0.347341395764466 0.359259881643258 no 1204 0.36416742751437 377 5127859
SGTC_1905 st060207 84.5 µM 0.347304883050917 0.359274450684946 no 1205 0.364181141351073 392 1948547
SGTC_2744 captopril 92.04 µM 0.346517599505286 0.359588636670971 no 1206 0.364476880026072 391 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1268 0828-0275 2.46 µM 0.345957500683006 0.359812216488943 no 1207 0.36468732715893 392 745337
SGTC_1750 st081859 2.357 µM 0.345606556509946 0.359952330569786 no 1208 0.364819208952263 406 5291695
SGTC_540 1187-0821 17.3 µM 0.345118949789557 0.36014703826154 no 1209 0.365002473902732 431 847520
SGTC_1379 2144-0755 36.5 µM 0.344004355666957 0.360592246357664 no 1210 0.365421505218709 423 5392327
SGTC_1881 5652484 16 µM 0.343782095301439 0.360681047590472 no 1211 0.365505083166428 414 2255129
SGTC_1395 3486-0190 4.35 µM 0.343423527736033 0.360824324424077 no 1212 0.365639931019052 407 6748079
SGTC_252 miconazole 1.30953 nM 0.343354092868145 0.360852071545489 no 1213 0.3656660455706 405 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1987 st072290 61.9 µM 0.341956885433322 0.361410570189566 no 1214 0.36619166941754 414 54697379
SGTC_3329 9141233 27.5565 µM 0.34158442825784 0.361559500535261 no 1215 0.366331828760138 399 4909101 YNL103W MET4
SGTC_1116 jasmonic acid 1.58368 µM 0.341529914599303 0.361581300071345 no 1216 0.366352344288934 419 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.340639063979314 0.361937607073814 no 1217 0.366687658783854 435 1273210
SGTC_1090 efavirenz 20.7 µM 0.340097851863253 0.362154130193051 no 1218 0.366891419714062 404 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1716 st033144 30.6155 µM 0.33990954134193 0.362229478067298 no 1219 0.366962325534094 424 674617
SGTC_1453 4237-0541 195 µM 0.339458402643074 0.362410011952603 no 1220 0.367132214263079 377 739892
SGTC_3041 9091929 49.47 µM 0.33743045778243 0.363221919788319 no 1221 0.367896213793249 394 25236887
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.335712616533195 0.363910155861258 no 1222 0.368543795421112 408 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1486 3970-0793 4.53 µM 0.333564785575502 0.364771280805591 no 1223 0.369353997357663 421 2844330
SGTC_829 1635-0120 117 µM 0.33314270836015 0.364940583650249 no 1224 0.369513281134586 388 285054
SGTC_2647 atorvastatin 60.16 µM 0.332600324379469 0.365158182387407 no 1225 0.369717999239479 405 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1184 1269-1718 139 µM 0.332060801235928 0.365374676468848 no 1226 0.369921674188607 379 5403821
SGTC_179 1273-0063 6.77 µM 0.331949097289783 0.365419505197847 no 1227 0.369963848017349 421 3108139
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.329577644418429 0.366371643280033 no 1228 0.370859558399531 377 66535 A nucleotide analog.
SGTC_851 0394-0702 453 µM 0.328981868744314 0.366610976760134 no 1229 0.371084696295413 410 762646
SGTC_1494 4358-1428 177 µM 0.328344883264883 0.36686692231886 no 1230 0.371325455794089 411 1564571
SGTC_270 tamoxifen 5.46 µM 0.327980205640611 0.367013479185597 no 1231 0.371463314580753 422 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2782 7736369 71.43 µM 0.326832441231514 0.367474869859911 no 1232 0.371897310575229 398 2950836 YOL077C BRX1
SGTC_1561 5-methoxyflavone 52.9 µM 0.3263775785933 0.367657773420089 no 1233 0.372069349631466 419 94525
SGTC_71 0417-1750 47.813 µM 0.326295254304663 0.36769087982208 no 1234 0.372100489219147 370 6811472
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.325427322166815 0.3680399752334 no 1235 0.372428839897492 395 88881 An O-methylated flavonoid and antioxidant.
SGTC_2186 6124449 200 µM 0.324248199110707 0.368514410927572 no 1236 0.372875066945167 415 3834182 YLR033W RSC58
SGTC_670 4204-0025 119 µM 0.323853294518666 0.368673350852066 no 1237 0.373024552716656 435 719039
SGTC_481 bay k-8644 50 µM 0.323116098589369 0.368970115188574 no 1238 0.373303659369213 400 2303 A calcium channel antagonist.
SGTC_103 0844-0104 51.839 µM 0.322984388104052 0.369023144568613 no 1239 0.373353532727446 385 5375804
SGTC_503 tyrphostin 8 294 µM 0.322875471527453 0.369066998530391 no 1240 0.373394776570133 437 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_3091 9116372 49.47 µM 0.322874519516823 0.369067381853643 no 1241 0.373395137077913 377 17169793
SGTC_1511 0906-3109 28.5 µM 0.322678501797752 0.369146310372909 no 1242 0.373469367508811 387 2882180
SGTC_1269 0831-0796 3.05 µM 0.321311355362156 0.369696958992454 no 1243 0.373987225979765 409 927758
SGTC_2622 2-methoxyxanthone 59.94 µM 0.321143991489511 0.36976438690108 no 1244 0.374050637032327 387 71034 A hepatoprotective.
SGTC_2816 7982706 58.44 µM 0.32048892398585 0.370028340367065 no 1245 0.374298862664658 388 2981853
SGTC_1961 st076550 68.7 µM 0.319062604857555 0.370603274291555 no 1246 0.374839519893262 391 1579337
SGTC_2719 novobiocin 32.65 µM 0.318320055394536 0.370902702520589 no 1247 0.375121086448275 416 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1218 1348-1416 30.7 µM 0.317993665817123 0.371034341737906 no 1248 0.375244870837983 377 6787668
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.316718192717869 0.37154890926335 no 1249 0.375728721572756 424 65057 A dermal irritant. YDR527W RBA50
SGTC_552 k242-0005 476 µM 0.3162391929783 0.371742212769109 no 1250 0.375910480663024 436 4088318
SGTC_1617 st002906 78 µM 0.315923256171452 0.371869728856138 no 1251 0.376030379697355 423 5150859
SGTC_2116 5511452 16.8835 µM 0.312329641998215 0.373321143075977 no 1252 0.377395007471307 428 870744
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.309375609902308 0.374515586888376 no 1253 0.378517910711432 402 2374 Ca(2+)-ATPase inhibitor.
SGTC_1303 1160-0052 261 µM 0.309080361532617 0.374635035094601 no 1254 0.37863019875902 417 3562476
SGTC_1656 st012921 11 µM 0.307247921343095 0.375376651399622 no 1255 0.379327336189513 420 6732821
SGTC_774 k060-0086 136 µM 0.307153870442891 0.375414727679559 no 1256 0.379363127723996 425 5911235
SGTC_3169 9102970 49.47 µM 0.306940154016666 0.375501254770852 no 1257 0.379444462409083 405 17027839
SGTC_3261 9137475 49.47 µM 0.306859294438208 0.375533993916428 no 1258 0.379475236766664 415 17027690
SGTC_1647 st011722 22.4 µM 0.306263090726291 0.375775417834853 no 1259 0.379702169575684 391 2854783
SGTC_2674 ligustilide 100 µM 0.305501482236129 0.376083890727425 no 1260 0.37999212061811 414 5319022 A signalling regulator.
SGTC_1640 st009078 66.4 µM 0.305452462889707 0.376103747658048 no 1261 0.380010785026609 423 690618
SGTC_3162 9099653 49.47 µM 0.305355023093103 0.376143219890262 no 1262 0.380047886640133 399 25237511
SGTC_381 3461-2219 42.7 µM 0.305263913355753 0.376180129028508 no 1263 0.380082578990624 421 2883159
SGTC_2966 9084041 48.03 µM 0.304551243293693 0.376468875285945 no 1264 0.380353979520342 382 17741380
SGTC_2183 6420625 130.508 µM 0.302372460535357 0.377352061682285 no 1265 0.381184073042327 394 2897619
SGTC_545 4218-0007 221 µM 0.301805050788366 0.377582171127625 no 1266 0.381400340170267 417 2840508
SGTC_678 1218-2179 85.9 µM 0.301781973100772 0.377591531058576 no 1267 0.381409136970545 432 6820081 YOR116C RPO31
SGTC_677 0929-0063 136 µM 0.30016404395951 0.378247915427521 no 1268 0.382026014983442 414 1539583
SGTC_1138 3761-0006 1.03 µM 0.300078011522972 0.378282828142408 no 1269 0.382058825514905 420 12061087
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.299749670768025 0.378416080822799 no 1270 0.382184053914003 391 4000243
SGTC_2332 7982454 138.89 µM 0.299578541773983 0.378485536957129 no 1271 0.382249327000563 432 2981748
SGTC_2696 st077691 74.316 µM 0.297637092394132 0.379273787533627 no 1272 0.382990080629664 446 757133
SGTC_1602 st001878 87.6 µM 0.295962780356944 0.379953980741965 no 1273 0.38362925282541 437 595405 YLR310C CDC25
SGTC_3249 9135183 49.47 µM 0.295332590121517 0.380210093359312 no 1274 0.383869911444168 405 4902779
SGTC_2139 5578692 56.4705 µM 0.295103960275684 0.380303022719962 no 1275 0.383957232258007 415 650991 YMR113W FOL3
SGTC_255 tunicamycin 200.472 nM 0.294815717581115 0.380420192288491 no 1276 0.384067329459451 417 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2218 6965428 192.983 µM 0.294682475147224 0.380474358544335 no 1277 0.384118225912241 405 675684
SGTC_2745 rifampicin 24.3 µM 0.294568928747774 0.380520519737753 no 1278 0.384161600375914 433 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2602 kawain 100 µM 0.294235239449871 0.380656187747204 no 1279 0.384289077315625 419 5369129
SGTC_341 1486-1430 230 µM 0.293234441034805 0.381063170175383 no 1280 0.384671480200761 418 2054753 YPL210C SRP72
SGTC_1340 1486-1359 257 µM 0.292070814576427 0.381536533325474 no 1281 0.385116240418175 419 4309068
SGTC_161 4065-0411 162.148 µM 0.292070152407348 0.381536802746326 no 1282 0.385116493554914 427 1906281 YLR208W SEC13
SGTC_3121 9125696 49.47 µM 0.291610809067172 0.381723712452133 no 1283 0.385292105020687 432 1235365
SGTC_336 4111-0029 111 µM 0.290812812764483 0.38204848773811 no 1284 0.385597242750342 425 3131175
SGTC_2075 5212009 200 µM 0.290396844807952 0.382217814827375 no 1285 0.385756328618327 453 780898
SGTC_3075 9116269 49.47 µM 0.290247192565416 0.382278738922779 no 1286 0.385813567433092 430 17015205 YNL244C SUI1
SGTC_2231 micatex 6.853 µM 0.290044246470488 0.38236136383911 no 1287 0.385891193990051 420 20737 An antifungal of unknown mechanism.
SGTC_68 0986-0284 82.829 µM 0.289634095302422 0.382528363966316 no 1288 0.386048090102508 368 423278 YIL048W NEO1
SGTC_1241 0364-0022 50.8 µM 0.287820765478525 0.3832669539307 no 1289 0.386741970558815 422 4563895
SGTC_641 4092-0595 30 µM 0.285126559082941 0.384365118213281 no 1290 0.387773591503259 421 786260
SGTC_567 1080-0542 68.4 µM 0.284965999486858 0.384430592057754 no 1291 0.387835095426416 413 5950415
SGTC_233 rapamycin 362 pM 0.284959306131913 0.384433321581171 no 1292 0.387837659442584 395 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1324 1418-0026 34.4 µM 0.284370100683946 0.384673619648427 no 1293 0.388063384881293 404 1372513
SGTC_742 0kpi-0133 140 µM 0.28435341087862 0.384680426965799 no 1294 0.388069779320483 439 2728852
SGTC_965 1291-5240 308 µM 0.282516445451316 0.385429892046292 no 1295 0.388773769159671 415 2834598
SGTC_590 k048-0076 22.4 µM 0.28146558219793 0.385858827296427 no 1296 0.389176661431221 433 6832814
SGTC_625 k213-0058 121 µM 0.280935912622077 0.386075077687855 no 1297 0.389379777563609 413 3655420
SGTC_2835 9006588 71.43 µM 0.280324268906889 0.386324840040842 no 1298 0.389614366500265 361 2345538
SGTC_649 1123-0311 367 µM 0.280255854642763 0.386352779673042 no 1299 0.389640608509956 428 693629 YIL048W NEO1
SGTC_385 1494-0393 12.4 µM 0.280078772712968 0.386425100719658 no 1300 0.389708535069133 432 3090647
SGTC_1659 st012954 42.1 µM 0.279946600079251 0.386479083181914 no 1301 0.389759237142936 414 24207262
SGTC_2462 5162487 171.77 µM 0.278172852474428 0.387203736280788 no 1302 0.390439836664174 438 2259986
SGTC_1740 st038286 13.222 µM 0.277981003353437 0.387282138609608 no 1303 0.390513470696264 383 716786
SGTC_2175 5807670 165.306 µM 0.277230603713491 0.387588846019656 no 1304 0.390801520925483 406 241186
SGTC_707 0865-0008 204 µM 0.276588299986153 0.387851427621278 no 1305 0.391048124803369 443 723043
SGTC_1022 4477-0945 21.3 µM 0.276522675179059 0.387878258733195 no 1306 0.391073323034004 412 4648966
SGTC_1365 1672-3266 55.4 µM 0.275872950610191 0.38814393154518 no 1307 0.391322825142866 450 6415873
SGTC_2151 5563267 85.4165 µM 0.275121992949416 0.388451063856578 no 1308 0.391611257700517 448 5310824
SGTC_1628 st004252 77.7 µM 0.274931305853304 0.388529063612339 no 1309 0.391684507497833 397 692968
SGTC_3267 9137951 49.47 µM 0.274868215786668 0.388554871328897 no 1310 0.391708743515547 432 16643986
SGTC_2957 9076800 11.52 µM 0.274833779442626 0.388568958118593 no 1311 0.391721972397298 408 16459615
SGTC_1094 duloxetine 25.4 µM 0.274649807639356 0.388644217489398 no 1312 0.391792648142084 407 60834 A selective serotonin reuptake inhibitor.
SGTC_389 tpck 16.7 µM 0.273381119049609 0.389163327558317 no 1313 0.392280132501726 392 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2326 6164455 177.58 µM 0.273221777177436 0.389228539574539 no 1314 0.392341370424971 428 2888790
SGTC_2148 5546263 113.568 µM 0.271750249903067 0.389830921857373 no 1315 0.392907030414263 410 792097
SGTC_2096 5468907 200 µM 0.271215661071963 0.390049825998677 no 1316 0.393112584228543 440 759785
SGTC_592 k241-0073 46.5 µM 0.270493764606119 0.390345484447605 no 1317 0.393390206662253 433 4230158
SGTC_470 aa-861 153 µM 0.270259273617262 0.390441535756305 no 1318 0.39348039741422 403 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_735 3076-0345 636 µM 0.269354111198747 0.390812367627337 no 1319 0.393828597754671 432 2888990
SGTC_1066 ketoconazole 628 nM 0.268071877947494 0.39133784985765 no 1320 0.394321995991559 447 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.267782487932228 0.391456474560658 no 1321 0.394433375602823 419 15053
SGTC_2640 pentamidine 10.38 µM 0.265867087118559 0.39224187612412 no 1322 0.395170786875754 426 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1248 0469-0687 58.6 µM 0.265411048996587 0.392428937372681 no 1323 0.395346412713179 419 4017482
SGTC_3327 9140648 26.9345 µM 0.265243152738197 0.392497812622715 no 1324 0.39541107696389 454 8029710
SGTC_2402 5553605 200 µM 0.262441427107152 0.393647645977872 no 1325 0.396490568693544 411 6758546
SGTC_1177 0983-0204 23.6 µM 0.262262415926845 0.393721144141375 no 1326 0.39655956793174 421 766818
SGTC_1417 3966-0327 90.4 µM 0.262250421166717 0.393726069068827 no 1327 0.39656419138623 439 651118
SGTC_1193 1488-0126 41.5 µM 0.261126057381885 0.394187796869725 no 1328 0.396997648855158 412 1384710
SGTC_1871 st057448 67.3 µM 0.261057918943024 0.394215783179787 no 1329 0.397023921241922 458 691747
SGTC_1929 genistein trimethyl ether 50.5 µM 0.259241170871807 0.394962172005157 no 1330 0.397724583417877 454 136420
SGTC_3085 9117376 49.47 µM 0.258949933741793 0.395081859169379 no 1331 0.397836935106215 424 16480349
SGTC_3185 9108267 49.47 µM 0.258094097255614 0.395433632022082 no 1332 0.398167143502534 430 4910486
SGTC_642 0335-0876 158 µM 0.255737699108038 0.396402617407313 no 1333 0.399076691604443 445 6812350
SGTC_1334 1486-0610 236 µM 0.254943556251451 0.396729325114737 no 1334 0.399383347233757 414 3742339
SGTC_2571 chrysanthemic acid 100 µM 0.254368411941071 0.396965982840566 no 1335 0.39960547608015 439 2743 An insecticide.
SGTC_2558 carylophyllene oxide 100 µM 0.252867216967176 0.397583866203361 no 1336 0.400185411701802 456 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_3184 9108758 49.47 µM 0.252565567684397 0.397708054406294 no 1337 0.400301970249603 441 902885
SGTC_3107 9121808 49.47 µM 0.252184303756262 0.397865034576886 no 1338 0.400449304934533 401 662681
SGTC_3256 9138902 49.47 µM 0.251659813506563 0.39808101323078 no 1339 0.40065201078834 447 17228773
SGTC_786 4544-0069 423 µM 0.249757365912452 0.398864679469501 no 1340 0.401387496027374 419 748821 YLR208W SEC13
SGTC_857 0438-0306 1.35 µM 0.248839194724868 0.399243043512091 no 1341 0.401742585740171 394 4686136
SGTC_3230 9131665 49.47 µM 0.245976928816497 0.400423144751707 no 1342 0.402850046021152 450 15943720
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.245938672848462 0.40043892372421 no 1343 0.402864853219272 455 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2069 5228469 200 µM 0.244150937445133 0.401176469939449 no 1344 0.403556961780311 439 2835210
SGTC_273 hydroxyurea 18.1 mM 0.244002515041915 0.401237718802577 no 1345 0.403614436030586 431 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1983 st071813 46.9 µM 0.242118507972866 0.402015394704483 no 1346 0.404344168749622 430 11838595
SGTC_2051 5263410 176 µM 0.241091665989357 0.402439415668287 no 1347 0.404742035938089 431 227584
SGTC_1590 st077108 57.8 µM 0.23962700565319 0.403044426557753 no 1348 0.405309713576465 452 5489485
SGTC_3278 9139605 49.47 µM 0.238764805372632 0.403400686441993 no 1349 0.405643981114593 432 7958859
SGTC_2840 9008771 71.43 µM 0.236989343949537 0.404134556729847 no 1350 0.406332528552631 423 2992978
SGTC_231 b-estradiol 524 µM 0.236582652880752 0.404302706262183 no 1351 0.406490289596593 429 450 A steroid.
SGTC_446 go6976 132 µM 0.235663240143555 0.404682909608172 no 1352 0.406846998319915 468 3501 A protein kinase C inhibitor.
SGTC_1256 0570-0116 285 µM 0.235456352735636 0.404768475861198 no 1353 0.406927276028316 419 410638
SGTC_2669 eugenol 100 µM 0.234837294321524 0.405024538487967 no 1354 0.407167510178658 448 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2244 6635614 200 µM 0.234333516298442 0.405232947427208 no 1355 0.407363033964996 413 836499
SGTC_1616 st002734 56.1 µM 0.233338951112017 0.405644469940704 no 1356 0.407749107315574 432 4026101
SGTC_1964 st076914 61 µM 0.232907661641562 0.405822957589178 no 1357 0.407916554454228 459 24208661
SGTC_516 3992-2719 87.3 µM 0.232638618204026 0.40593431019992 no 1358 0.408021018467448 407 5350887 YDR037W KRS1
SGTC_1038 k292-0204 154 µM 0.230837534905483 0.406679944255474 no 1359 0.408720509984035 432 4454212
SGTC_2955 9076254 12.21 µM 0.230531683007971 0.406806598181674 no 1360 0.408839323450957 452 16459619
SGTC_2886 9058944 51.95 µM 0.228119079729778 0.407806003063029 no 1361 0.409776833815845 438 4949929
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.226882700697571 0.40831839789545 no 1362 0.410257477075127 426 803109
SGTC_2165 5727197 32.143 µM 0.226572829212609 0.408446843111509 no 1363 0.410377961003578 446 1361712
SGTC_2600 tangeritin 87.95 µM 0.225772589069682 0.408778597121048 no 1364 0.410689148699993 440 68077 A bioactive flavone.
SGTC_998 3996-0085 177 µM 0.225612596982268 0.408844932580251 no 1365 0.410751371236218 437 715391
SGTC_3062 9077494 49.47 µM 0.224728654500107 0.409211477286902 no 1366 0.411095185824884 417 16459633
SGTC_673 1082-0474 110 µM 0.224303695881882 0.40938772329014 no 1367 0.41126050028822 454 3098046
SGTC_1575 cyproterone acetate 48 µM 0.221891952657034 0.410388308032256 no 1368 0.412198997618848 451 9880 An androgen receptor antagonist and liver toxin.
SGTC_2952 9073731 13.78 µM 0.219841144997232 0.411239607132324 no 1369 0.412997437167648 407 16457353
SGTC_1154 4088-0362 150 µM 0.219543661878859 0.411363128476273 no 1370 0.413113286045617 448 6618304
SGTC_3197 9113331 49.47 µM 0.219428076867693 0.411411124212325 no 1371 0.413158300368683 407 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2741 miltefosine 3.04 µM 0.218673924890691 0.411724312203083 no 1372 0.413452031163052 468 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1245 0418-0076 17.2 µM 0.218357478289593 0.411855744488335 no 1373 0.413575296768035 460 6790114
SGTC_871 0574-0004 149 µM 0.217881284279506 0.412053544569685 no 1374 0.413760804911461 465 9551173
SGTC_554 4483-2211 187 µM 0.217493063376627 0.412214819174786 no 1375 0.4139120561254 436 747107
SGTC_2097 5376186 200 µM 0.217197986261591 0.412337409935058 no 1376 0.414027026979524 421 742755
SGTC_2173 5763948 167 µM 0.217159301049482 0.412353482468407 no 1377 0.414042100439743 470 2867177
SGTC_3044 9093193 49.47 µM 0.216212591805231 0.412746857220386 no 1378 0.414411019418185 467 25236277
SGTC_1025 k007-0731 70 µM 0.215859027459427 0.412893792077113 no 1379 0.414548817745497 419 6256118
SGTC_2673 kobusone 100 µM 0.215811094161356 0.412913713216469 no 1380 0.414567500100598 460 6710676 An epoxy ketone and protein crosslinker.
SGTC_3350 9150499 3.57 µM 0.215659960888865 0.412976525863939 no 1381 0.414626406669088 464 4910996 YPR165W RHO1
SGTC_2362 9071156 126 µM 0.21431125522511 0.413537161221034 no 1382 0.415152170768851 432 653133
SGTC_1559 coumarin 343 70.1 µM 0.213842737557307 0.413731957837913 no 1383 0.415334847992493 433 108770 A hepatotoxic, DNA x-linker.
SGTC_1115 galangin 695.678 nM 0.213504465667201 0.413872615083794 no 1384 0.415466753160334 478 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1049 3226-0134 66 µM 0.212523429826807 0.414280603221853 no 1385 0.415849350441584 442 5702385
SGTC_2269 7935389 174.42 µM 0.211338974206602 0.414773311772587 no 1386 0.416311386321192 447 97605
SGTC_2732 terfenadine 20 µM 0.209952482590366 0.415350233355991 no 1387 0.416852379893222 474 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2441 5730946 39.09 µM 0.209717862694005 0.415447877197606 no 1388 0.416943941569887 423 1774275
SGTC_598 3937-0236 20.2 µM 0.208540079453222 0.415938124468575 no 1389 0.417403645792984 459 1379313
SGTC_2294 7971431 200 µM 0.208167142529959 0.416093385189336 no 1390 0.41754923152644 471 5741572
SGTC_1514 1189-1591 158 µM 0.20706609916005 0.416551846761506 no 1391 0.417979118626048 474 767698 YMR146C TIF34
SGTC_2343 7990716 14.84 µM 0.206261211281468 0.416887064526799 no 1392 0.418293437971937 454 6456862
SGTC_939 1165-0479 45.3 µM 0.20531062907854 0.417283038535531 no 1393 0.418664720071681 462 1377347
SGTC_1028 k015-0029 4.8 µM 0.204858577472869 0.417471374372308 no 1394 0.418841309594026 467 4588309
SGTC_792 4534-1957 155 µM 0.203917153947103 0.417863655335996 no 1395 0.419209119906643 433 1717904
SGTC_1581 himbacine 57.9 µM 0.203215049284408 0.41815626796149 no 1396 0.419483475308595 448 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_653 0203-0016 55.2 µM 0.202319474574383 0.418529577858374 no 1397 0.41983348813469 459 295302
SGTC_2333 9017922 200 µM 0.201576811790287 0.418839203876548 no 1398 0.420123787302094 453 3163164
SGTC_1620 st003704 16.5 µM 0.200204201443615 0.419411595642467 no 1399 0.420660440709384 463 2834414
SGTC_924 2046-0044 21.3 µM 0.200110529931852 0.419450663798356 no 1400 0.420697069116397 428 3623589
SGTC_559 1550-0661 158 µM 0.199478579943946 0.419714255812997 no 1401 0.420944198687063 466 5830875
SGTC_1300 1094-0077 113 µM 0.196658747001713 0.420890870864683 no 1402 0.422047297358509 443 5532636
SGTC_3096 9117468 49.47 µM 0.195371653950332 0.421428164229352 no 1403 0.422551002936634 482 41316311
SGTC_2843 9000894 45.46 µM 0.194887728349075 0.421630215513257 no 1404 0.422740420676094 435 2242070
SGTC_2336 9001819 198.65 µM 0.194577847775653 0.421759609398768 no 1405 0.422861723246935 486 2989602
SGTC_1125 tnp00248 1.32998 µM 0.194542360859185 0.42177442787252 no 1406 0.422875615046796 458 24207736
SGTC_859 0439-0102 54.6 µM 0.194240953841432 0.421900292580597 no 1407 0.422993608480307 448 610143
SGTC_3065 9113888 49.47 µM 0.192436405571836 0.422654021234475 no 1408 0.423700188873854 445 16648368
SGTC_2792 7535235 81.82 µM 0.191864472868734 0.422892966897556 no 1409 0.423924183461789 432 1281891
SGTC_1979 st071809 45.3 µM 0.191647606015859 0.4229835783264 no 1410 0.424009124713363 475 4976333
SGTC_2224 6650123 117.647 µM 0.191613488407263 0.422997833735598 no 1411 0.424022488037711 477 2908370
SGTC_2005 4024620 188 µM 0.189297181433579 0.423965894427713 no 1412 0.424929952140072 488 236743
SGTC_2735 sertaconazole 140 nM 0.188831694225152 0.424160492382307 no 1413 0.425112365148711 456 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_3131 9127911 49.47 µM 0.187562546480198 0.424691156202652 no 1414 0.425609794336928 434 45595681
SGTC_370 0180-0345 38.7 µM 0.186626082869502 0.425082803684029 no 1415 0.425976907429476 427 3989527
SGTC_2830 7992007 71.43 µM 0.185948715210743 0.425366138261913 no 1416 0.42624248956297 475 1952075
SGTC_2508 celastrol 40.54 µM 0.185829609938621 0.425415962524589 no 1417 0.426289191788413 433 122724 Celastrol is a natural product and antioxidant.
SGTC_1891 st059073 26.2 µM 0.185155298135376 0.425698063898255 no 1418 0.426553614854433 484 688754
SGTC_1149 3909-7961 23.3 µM 0.184964916094725 0.42577771797235 no 1419 0.42662827680785 463 735261
SGTC_2009 4012297 12.05 µM 0.184914220515518 0.425798929041696 no 1420 0.426648158490866 436 45595307
SGTC_1760 st045453 10.4495 µM 0.184005424227439 0.426179206474229 no 1421 0.42700459983155 493 3323419 YIL048W NEO1
SGTC_2820 7989630 71.43 µM 0.183652714827119 0.426326812984541 no 1422 0.42714295296957 464 2984098
SGTC_1652 st011932 78 µM 0.183528623786797 0.426378746705115 no 1423 0.427191630823973 455 1551076
SGTC_80 0159-0065 512.242 µM 0.183327824608312 0.426462786486928 no 1424 0.427270401737028 464 1548079
SGTC_3095 9117207 49.47 µM 0.182795160294969 0.426685736796468 no 1425 0.427479373078413 477 17015229
SGTC_2260 7964312 200 µM 0.182732761000072 0.426711855984502 no 1426 0.427503854489773 440 231951
SGTC_2847 9005661 71.43 µM 0.182608505317098 0.426763868066884 no 1427 0.427552605142578 469 2991449
SGTC_418 lividomycin a 100 µM 0.182048766313819 0.426998184524483 no 1428 0.427772227650169 448 72394 An antibiotic.
SGTC_1856 st057054 55.7 µM 0.18100557725683 0.427434950244904 no 1429 0.428181599154439 470 1266018
SGTC_1142 3253-1408 9.78 µM 0.180502739599175 0.427645511724231 no 1430 0.428378951915662 466 256655
SGTC_1942 st076330 65.2 µM 0.179284947591363 0.428155543075144 no 1431 0.428856982721544 474 24208414
SGTC_3192 9110362 49.47 µM 0.177709588071109 0.428815507564889 no 1432 0.429475527459006 462 16649480
SGTC_172 1112-0046 2.638 µM 0.177618379609572 0.428853723589478 no 1433 0.429511344611323 452 2802135 YIL048W NEO1
SGTC_1362 1611-0397 101 µM 0.176736457607006 0.429223280160407 no 1434 0.429857701300007 441 27816
SGTC_2467 5474540 200 µM 0.175853309099546 0.429593412855151 no 1435 0.430204593775815 466 5413519
SGTC_284 0988-0104 32.6 µM 0.175243774229599 0.429848908600589 no 1436 0.430444044814501 467 4666532
SGTC_913 3487-1245 167 µM 0.172487006203178 0.431004814955909 no 1437 0.431527337906786 454 4016153
SGTC_1242 0402-0103 60.1 µM 0.172400817875579 0.431040963101963 no 1438 0.431561214617303 442 432868
SGTC_2366 9070441 60.58 µM 0.171920320486193 0.431242498531311 no 1439 0.431750085500129 445 6837235
SGTC_2152 5568786 200 µM 0.171487621081902 0.431424001332632 no 1440 0.431920181605485 481 5399883
SGTC_2751 anetholtrithion 17.25 µM 0.170987037738368 0.431633997220288 no 1441 0.43211697894201 467 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2021 4019055 173 µM 0.17095292214197 0.431648309497021 no 1442 0.43213039162501 469 44827708 YER133W GLC7
SGTC_870 0573-2213 57.6 µM 0.170811582811564 0.431707605550098 no 1443 0.432185960580546 472 3916321
SGTC_3291 9121177 71.43 µM 0.169945831894168 0.432070847342143 no 1444 0.432526368352222 439 17015612
SGTC_174 3553-0389 74.3 µM 0.169938271324987 0.432074019772037 no 1445 0.432529341341068 449 738071
SGTC_331 k048-0133 24.5 µM 0.169494452557067 0.432260254679659 no 1446 0.432703867726445 444 6813582
SGTC_685 1278-0033 54.9 µM 0.169486973701494 0.432263393080655 no 1447 0.432706808808907 488 3590572
SGTC_373 0844-0104 25.9 µM 0.168711977449068 0.432588632951614 no 1448 0.433011598597094 458 5375804
SGTC_974 1326-0144 138 µM 0.168516840632273 0.432670532520302 no 1449 0.433088348106391 472 5411856
SGTC_2760 etidronate 98.04 µM 0.167856212714332 0.432947821699193 no 1450 0.433348199230855 472 3305 A chelator and antioxidant.
SGTC_1885 st057546 99.9 µM 0.167600144319238 0.433055311655578 no 1451 0.433448928827974 439 702008
SGTC_2869 9037858 32.47 µM 0.167225428513766 0.433212615218986 no 1452 0.433596338534201 482 27187042
SGTC_2032 5185112 25.99 µM 0.166704948664211 0.433431127250826 no 1453 0.433801105778903 487 5718189
SGTC_1374 2889-5571 141 µM 0.166589385971348 0.433479646472093 no 1454 0.433846572879705 447 2853281
SGTC_802 4112-3352 742 µM 0.165326030205043 0.434010134078761 no 1455 0.434343685791949 429 704594
SGTC_5 0352-0601 109.883 µM 0.164730910799282 0.434260068092418 no 1456 0.434577893021956 449 762456
SGTC_3182 9108849 49.47 µM 0.164565377378858 0.434329592316369 no 1457 0.434643042224978 452 17133045
SGTC_1352 1496-0991 99 µM 0.162925872060915 0.43501829575202 no 1458 0.435288400019322 498 3000039
SGTC_3306 9127676 59.7925 µM 0.162649124953983 0.435134567816876 no 1459 0.435397352921274 441 41905287
SGTC_2769 toremifene 3.73 µM 0.162323076954685 0.435271560271915 no 1460 0.435525721443041 466 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_340 k038-0059 454 µM 0.162283190470018 0.435288319526608 no 1461 0.435541425637654 467 23733424
SGTC_257 daunorubicin 18.5 µM 0.161610601303733 0.435570941336031 no 1462 0.435806254215827 470 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_945 3381-0768 11.3 µM 0.16113385464018 0.435771290111864 no 1463 0.435993988241814 492 1126236 YIL048W NEO1
SGTC_3151 9099821 49.47 µM 0.160346502131354 0.436102204451498 no 1464 0.436304064667616 454 17174189
SGTC_1815 st051655 58.2 µM 0.160049806666224 0.436226913434438 no 1465 0.43642091991672 473 5984156
SGTC_1938 st074717 56.4 µM 0.159071671960872 0.436638094264884 no 1466 0.436806203255796 471 17250979
SGTC_1834 st055981 52.8 µM 0.157793017761238 0.437175708386335 no 1467 0.437309950374573 487 471719 YDL150W RPC53
SGTC_848 0368-0089 85.6 µM 0.157672600765681 0.437226344078748 no 1468 0.437357395905165 500 762535
SGTC_522 1273-0010 11.6 µM 0.156926226777081 0.437540219391443 no 1469 0.437651494977456 484 5705015
SGTC_3206 9114350 49.47 µM 0.156663603888906 0.437650670489637 no 1470 0.437754986350725 483 17087243
SGTC_1315 1237-0019 3.69 µM 0.156406202658504 0.437758930233963 no 1471 0.437856424165802 489 825140
SGTC_626 0214-0009 33 µM 0.15638851283944 0.437766370522232 no 1472 0.437863395597973 470 3437874
SGTC_1475 4092-1048 11.7 µM 0.155548026052928 0.438119902218494 no 1473 0.438194647665635 462 2881759
SGTC_345 1362-0200 395 µM 0.155087328955294 0.438313704974277 no 1474 0.438376235675626 454 1419823
SGTC_2133 5320837 200 µM 0.154758896543373 0.438451876604912 no 1475 0.43850569826395 465 2841355
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.153006383258338 0.439189285975833 no 1476 0.439196620727152 492 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2065 5221596 34.26 µM 0.152407316665606 0.439441405254766 no 1477 0.439432843314273 459 788581
SGTC_2115 tiliquinol 12.7705 µM 0.152308831119783 0.439482855596457 no 1478 0.439471679979075 480 71208 A bioactive hydroxyquinoline.
SGTC_2623 humulene 100 µM 0.152286846819891 0.43949210838231 no 1479 0.439480349319464 454 6187145 An anti-inflammatory.
SGTC_1491 4138-0063 26.5 µM 0.151761844992129 0.439713081765832 no 1480 0.439687388385183 481 23883227
SGTC_706 4262-0057 46.9 µM 0.149513391597854 0.440659667936784 no 1481 0.440574271584835 466 883298
SGTC_1332 1480-0653 17.5 µM 0.149398399056621 0.440708088309512 no 1482 0.440619637461238 493 5749438
SGTC_2762 leflunomide 42.06 µM 0.148454961216218 0.441105378890476 no 1483 0.440991863884284 464 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_3035 9091303 49.47 µM 0.147951520241482 0.441317406918414 no 1484 0.441190514152321 488 25237002
SGTC_2529 gangaleoidin 93.61 µM 0.147707890205138 0.441420019619839 no 1485 0.441286652231576 489 4565183
SGTC_563 tetrahydrosecaminediol 614 µM 0.147261656949015 0.441607975438582 no 1486 0.441462747895177 463 334274 A psychoactive constituent of the cannabis plant.
SGTC_1279 0874-0590 65.2 µM 0.145502572661772 0.4423490387822 no 1487 0.442157042338295 459 3523074
SGTC_1787 fluconazole 80 µM 0.14457665740643 0.442739187645014 no 1488 0.4425225641305 474 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2943 9068529 45.32 µM 0.144461681785326 0.442787638303546 no 1489 0.442567956257984 505 3270634
SGTC_335 4077-0256 27.6 µM 0.144303749287067 0.442854192359301 no 1490 0.442630308896998 490 3121989
SGTC_1989 st071868 50.2 µM 0.144197353877763 0.442899029170409 no 1491 0.442672315204509 497 16414057
SGTC_2981 9013952 38.96 µM 0.143815177275048 0.443060090831772 no 1492 0.442823208867649 447 2996344
SGTC_2380 9035439 200 µM 0.142885017637097 0.443452129647837 no 1493 0.443190495673944 450 6462575
SGTC_3293 9120939 62.045 µM 0.142242788540406 0.443722845334489 no 1494 0.443444117505437 483 934087
SGTC_579 4491-1009 110 µM 0.141100826946022 0.444204275606939 no 1495 0.443895145190023 510 1271041
SGTC_824 1304-0008 100 µM 0.140225738606458 0.444573252723794 no 1496 0.444240818174552 470 768245
SGTC_1829 berberine 14.4 µM 0.138191488563688 0.445431170320231 no 1497 0.445044540850503 479 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1990 st072050 59.8 µM 0.135287754935385 0.446656222800917 no 1498 0.446192183107985 501 17233948
SGTC_962 1254-0300 21.5 µM 0.134981619334023 0.446785407837374 no 1499 0.446313203482595 486 7340576
SGTC_1898 st060199 18.6 µM 0.134957339882917 0.446795653675524 no 1500 0.446322801758083 461 688866
SGTC_1047 2043-3044 82 µM 0.134528514028864 0.446976622439285 no 1501 0.446492332543125 491 669592
SGTC_254 nsc-64875 3.808 µM 0.134289745032918 0.447077390111668 no 1502 0.446586731035062 494 56993
SGTC_1358 1509-0022 2.48 µM 0.134170220675331 0.447127834256461 no 1503 0.446633986712391 452 3258434
SGTC_2029 5175081 200 µM 0.133373745966785 0.447464000810509 no 1504 0.446948903785654 468 1380876
SGTC_387 norethindrone acetate 66.7 µM 0.133066881225528 0.447593528709125 no 1505 0.447070243565146 472 541197
SGTC_394 menadione 8.33 µM 0.132956054164511 0.447640310291274 no 1506 0.447114067775765 499 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_752 1896-0090 130 µM 0.132208213204547 0.447956002952713 no 1507 0.447409802475522 479 772567
SGTC_1185 1319-0113 81.3 µM 0.13105080072554 0.448444656553136 no 1508 0.447867560365301 496 4672763
SGTC_2593 nobiletin 86.24 µM 0.130528323851373 0.448665269276975 no 1509 0.448074223319097 462 72344 An anti-infammatory.
SGTC_524 r073-0010 27.8 µM 0.129575917528733 0.449067457925164 no 1510 0.448450978807749 482 2772106
SGTC_1441 4106-0040 13 µM 0.129335489318023 0.449168995882749 no 1511 0.448546095418426 471 2904180
SGTC_2313 7726885 200 µM 0.128478922914579 0.449530769141438 no 1512 0.448884988527919 466 726423
SGTC_1704 st028805 70.8 µM 0.128303304065224 0.44960494745489 no 1513 0.448954475226333 468 2876101
SGTC_1237 0330-0133 46.1 µM 0.128023210014354 0.449723257899229 no 1514 0.449065302621891 481 X1237 YHR072W ERG7
SGTC_1013 4112-3890 241 µM 0.127389522157583 0.449990941225114 no 1515 0.449316054392004 502 705171
SGTC_1813 st051246 8.6015 µM 0.12659296219367 0.450327457483236 no 1516 0.449631283740312 488 5291959
SGTC_3161 9100388 49.47 µM 0.12642004335696 0.450400513834864 no 1517 0.449699718566538 490 25236368
SGTC_1145 3546-0597 10.2 µM 0.12627931568662 0.450459971004964 no 1518 0.449755414434032 463 875334
SGTC_2382 9035899 200 µM 0.125796341581371 0.450664035083263 no 1519 0.449946568882117 509 6462679
SGTC_182 3448-4371 550.524 µM 0.125203328335793 0.450914610243936 no 1520 0.450181291175108 487 3491403
SGTC_624 k048-0052 28 µM 0.124946520697633 0.451023129267726 no 1521 0.450282944363982 465 6835531
SGTC_684 1140-0066 328 µM 0.124482920967134 0.451219041545207 no 1522 0.450466461143959 473 6813534
SGTC_2310 7668677 200 µM 0.124314676521585 0.451290142785975 no 1523 0.450533063629012 496 2197143
SGTC_1568 digitonin 820 nM 0.121598737913159 0.452438131472398 no 1524 0.451608406535978 489 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1186 1319-0216 26 µM 0.121216499703797 0.452599730282587 no 1525 0.451759777805076 475 4565136
SGTC_1420 4'-methoxyflavone 42 µM 0.120694741056827 0.452820326802921 no 1526 0.451966412286749 489 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_640 3381-0960 37.1 µM 0.119686162099495 0.453246789340221 no 1527 0.452365881300203 487 1745025
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.119620036137502 0.453274751603903 no 1528 0.452392073573965 497 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1761 st044296 37 µM 0.118777661410105 0.453630981457047 no 1529 0.45272575349543 480 1826700
SGTC_2285 7945142 200 µM 0.117793669823863 0.454047146555729 no 1530 0.453115572688503 496 2970608
SGTC_106 0092-0003 11.579 µM 0.117597260576779 0.454130221079353 no 1531 0.453193387814332 494 1072148
SGTC_596 1155-0152 116 µM 0.117524052062251 0.454161186339052 no 1532 0.453222392661087 507 280313
SGTC_724 3910-0327 137 µM 0.117255586305481 0.454274742615618 no 1533 0.453328759583555 507 2885483
SGTC_2650 prasterone 100 µM 0.117041976664224 0.454365098394059 no 1534 0.453413394744092 498 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2026 5148700 152 µM 0.116010977501584 0.454801238854994 no 1535 0.453821920876963 478 79838
SGTC_1350 1495-0454 146 µM 0.115319863473553 0.455093629274092 no 1536 0.454095797310294 501 1069057
SGTC_2067 5224629 34.075 µM 0.11480233599649 0.455312596167631 no 1537 0.454300898721771 469 2835000
SGTC_1718 roemerine 11.9335 µM 0.114772601199713 0.455325177431706 no 1538 0.454312683295369 479 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2755 lomerizine 42.69 µM 0.11423621464427 0.455552138771791 no 1539 0.454525272335273 470 3949 A calcium channel blocker.
SGTC_993 3909-8757 62.7 µM 0.114199205239963 0.455567799103558 no 1540 0.454539940957571 484 4288324 YLR208W SEC13
SGTC_1109 tnp00067 928.257 nM 0.113285357981487 0.455954510528576 no 1541 0.454902162573556 494 676295
SGTC_171 k064-0041 9.68 µM 0.111515289270167 0.456703666320269 no 1542 0.455603871067007 475 53325
SGTC_2496 diffractaic acid 79.83 µM 0.111486646571488 0.456715790197751 no 1543 0.455615227039304 469 94870 An apoptosis inducer which activates caspases.
SGTC_705 1124-0212 310 µM 0.110123200422092 0.45729295589967 no 1544 0.456155834390446 507 9554485
SGTC_2828 7998861 71.43 µM 0.109476856084699 0.457566593990055 no 1545 0.456412138794978 499 2988188
SGTC_19 0279-0214 38.434 µM 0.109118923616271 0.457718137912983 no 1546 0.456554082818607 508 3566274 YBR002C RER2
SGTC_1935 st074532 41.6 µM 0.10896136388237 0.457784848592274 no 1547 0.456616567488099 508 2829742
SGTC_2251 lansoprazole 556 µM 0.108505106505508 0.457978034343086 no 1548 0.456797515013304 498 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1726 st035556 14.5795 µM 0.108077776916016 0.458158980668823 no 1549 0.4569669981662 441 5919439
SGTC_2766 oltipraz 83.91 µM 0.106783618644164 0.458707025384076 no 1550 0.457480321794207 475 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1658 st012944 20 µM 0.106606858720776 0.458781885050923 no 1551 0.457550438562823 498 24207260
SGTC_2636 apigenin dimethyl ether 100 µM 0.10570655979783 0.459163193640199 no 1552 0.457907587774639 489 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2972 9093619 59.92 µM 0.105335303490794 0.459320444841555 no 1553 0.458054875325776 428 25236256
SGTC_1733 st037357 54.9 µM 0.105035914461729 0.459447260211773 no 1554 0.458173655354591 507 1272339 YGL099W LSG1
SGTC_3118 9124250 49.47 µM 0.103838093217111 0.45995467514694 no 1555 0.45864891791963 506 1504786
SGTC_1029 k015-0030 64.7 µM 0.101493369300064 0.460948123206255 no 1556 0.45957941045632 482 2208316
SGTC_911 3456-4043 236 µM 0.100254195949979 0.461473253750719 no 1557 0.46007126027661 483 914281
SGTC_615 k087-0205 167 µM 0.0982948219435003 0.462303723979428 no 1558 0.460849094881222 505 9642773
SGTC_1231 0242-0792 125 µM 0.0975151279387244 0.462634239044241 no 1559 0.461158660563679 496 3707635
SGTC_2656 pseudo-anisatin 100 µM 0.0970242890435683 0.462842320647118 no 1560 0.461353552789356 513 6708809 A neurotoxin.
SGTC_1147 3809-1045 12.3 µM 0.09501128846021 0.463695798839688 no 1561 0.462152930295188 485 325925
SGTC_2686 alizarin 95.37 µM 0.0949938920872714 0.463703175341477 no 1562 0.462159839195312 473 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2889 9059656 51.95 µM 0.0947782536218581 0.463794612535887 no 1563 0.462245480098979 494 3949838
SGTC_3321 9137793 26.8275 µM 0.0931132001244327 0.464500709327407 no 1564 0.462906815406929 498 4904192
SGTC_1850 st056238 17 µM 0.0926675116503822 0.464689730846085 no 1565 0.463083853932727 522 5393177
SGTC_408 cantharidin 100 µM 0.0925914966372659 0.464721970468856 no 1566 0.463114049713824 471 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1982 st072467 71.9 µM 0.0922965416145582 0.464847069509407 no 1567 0.463231218017508 477 3163533
SGTC_1399 3562-5772 25 µM 0.091470760986812 0.465197325636502 no 1568 0.463559269085164 504 23847490
SGTC_301 4119-0100 24.5 µM 0.0913520557393766 0.465247676873377 no 1569 0.463606428183282 510 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_728 3030-5151 22.5 µM 0.0912980243163244 0.465270595581008 no 1570 0.463627893900637 490 3125388
SGTC_76 0433-0009 400.328 µM 0.0912632605377233 0.465285341521868 no 1571 0.463641704983679 511 2841569
SGTC_1635 st007035 42.4 µM 0.0912452607410186 0.465292976612171 no 1572 0.463648856026967 494 3716403
SGTC_3023 9089636 49.47 µM 0.0897914339843415 0.465909697666111 no 1573 0.464226477691876 516 17249241
SGTC_1211 1056-0033 32.3 µM 0.0895362308684599 0.46601796467683 no 1574 0.464327880564831 512 6741922
SGTC_2877 9040724 71.43 µM 0.0893562069364996 0.466094339289638 no 1575 0.464399412997442 481 6463895
SGTC_1318 1280-3875 124 µM 0.0889623141153456 0.466261451487927 no 1576 0.46455593015208 491 373245
SGTC_1039 k821-0043 94 µM 0.0882352272642041 0.466569939536993 no 1577 0.46484485959304 494 15992768
SGTC_1074 carmofur 3.8 µM 0.0870133626396576 0.467088396796121 no 1578 0.465330445272182 506 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_457 grayanotoxin iii 135 µM 0.08579962118622 0.467603462550374 no 1579 0.465812853809611 510 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2984 9022109 38.96 µM 0.085313451033463 0.467809789954118 no 1580 0.466006099071236 501 6459207
SGTC_2089 5281248 129.67 µM 0.0852581746906963 0.467833249417691 no 1581 0.46602807108739 489 2737878
SGTC_296 1222-0039 74.9 µM 0.0846534359624819 0.468089909822823 no 1582 0.466268457869393 498 5984176
SGTC_2881 9058953 51.95 µM 0.0834218952919315 0.468612635499999 no 1583 0.466758039632355 512 17122249
SGTC_564 3555-0129 330 µM 0.0820812714038186 0.469181722880685 no 1584 0.467291043058873 515 563260
SGTC_1199 1638-0010 4.46 µM 0.0815440121222154 0.469409804195077 no 1585 0.467504662391636 498 3111136
SGTC_2356 9061756 188.97 µM 0.0809955054882103 0.469642670674666 no 1586 0.467722763431701 495 20104043
SGTC_565 1418-0001 44.5 µM 0.0807942974263554 0.469728095426689 no 1587 0.467802771619656 489 2862145
SGTC_379 3970-0972 5.9 µM 0.0800605622793499 0.470039621276036 no 1588 0.4680945443817 505 2898042 YBL034C STU1
SGTC_1489 4065-0444 182 µM 0.0795511567275444 0.470255913108459 no 1589 0.468297121658919 527 2877968
SGTC_2708 st078559 56 µM 0.0792747109162382 0.470373294719761 no 1590 0.468407060374291 523 17250902
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.0790656846812792 0.470462051025363 no 1591 0.468490188847002 502 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2267 7931562 200 µM 0.077552215166352 0.471104740956474 no 1592 0.469092127305862 506 934880
SGTC_2861 9024595 19.48 µM 0.0769457626934232 0.471362290251145 no 1593 0.46933334603481 521 16482810
SGTC_2570 licareol 100 µM 0.0762523274721047 0.471656794202074 no 1594 0.469609176264621 502 443158
SGTC_1336 1486-0901 104 µM 0.0760603423514926 0.471738333586312 no 1595 0.469685545462351 491 5006114
SGTC_1642 st009582 77.7 µM 0.0753294831548652 0.472048752872501 no 1596 0.469976281976831 512 6739311
SGTC_2939 9044578 71.43 µM 0.0752941903964172 0.472063743267552 no 1597 0.46999032187759 502 2653634
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.0738285086328275 0.472686317814939 no 1598 0.470573421156281 482 6708561
SGTC_1287 0971-0001 34.6 µM 0.0730457599144659 0.473018831767842 no 1599 0.470884851799085 506 4665869
SGTC_334 1502-1024 68.5 µM 0.0724483110470514 0.473272642465043 no 1600 0.471122569559419 513 3296216
SGTC_2655 perillic acid 100 µM 0.0710327020083808 0.473874070476104 no 1601 0.471685864389016 518 5702197 An apoptosis inducer.
SGTC_2789 5281112 71.43 µM 0.0709792146909977 0.47389679598509 no 1602 0.471707149016785 500 765948
SGTC_151 3013-0144 2.285 µM 0.0705713001232681 0.474070112124259 no 1603 0.471869476314127 522 906558 YHR107C CDC12
SGTC_2657 nystatin 74.44 µM 0.0689260980862108 0.474769180681949 no 1604 0.47252422232357 517 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1919 st067113 52.3 µM 0.068146320908706 0.475100545801502 no 1605 0.47283457863979 523 1268243
SGTC_2913 7966556 36.57 µM 0.0663179172295363 0.475877590290003 no 1606 0.473562359369885 526 2976516
SGTC_1276 0871-0068 94.2 µM 0.0661503945775539 0.475948789569306 no 1607 0.473629044804785 511 3414906
SGTC_2705 st078069 42.8 µM 0.065488171719419 0.476230250287853 no 1608 0.473892661860244 505 1530061
SGTC_1678 st019265 80.2 µM 0.0653935953659969 0.476270448494796 no 1609 0.473930311662151 516 5367020
SGTC_1854 st056233 32.9 µM 0.0647269860476789 0.476553787236244 no 1610 0.474195688055976 513 5393174
SGTC_3141 9094609 49.47 µM 0.0645520305179786 0.476628153122361 no 1611 0.474265339550536 520 25236309 YDL196W YDL196W
SGTC_3006 9075424 71.4286 µM 0.0640833231871185 0.476827383958999 no 1612 0.4744519403591 515 7465181
SGTC_538 2922-0838 53.3 µM 0.0640645775433379 0.476835352187071 no 1613 0.474459403453484 487 777039
SGTC_2058 5236698 133 µM 0.0632001260751722 0.477202815378879 no 1614 0.47480357219426 493 766665
SGTC_2589 lobaric acid 100 µM 0.0628569574356955 0.477348695754761 no 1615 0.474940205009911 506 73157 A novel microtubule depolymerizer.
SGTC_1062 mesoridazine 14.2 µM 0.0625314490575357 0.47748707159047 no 1616 0.475069809105024 517 4078 A neuroleptic.
SGTC_2860 9025725 38.96 µM 0.0621877444651166 0.477633185707035 no 1617 0.475206661049981 520 40546248
SGTC_1130 3454-2858 15.9 µM 0.0595863537978234 0.478739173056266 no 1618 0.476242543573961 530 715628 YIL048W NEO1
SGTC_3220 9131269 49.47 µM 0.0593468467848582 0.478841008385985 no 1619 0.476337924252247 529 17722206
SGTC_96 0929-0093 37.281 µM 0.0582668285541471 0.47930023543622 no 1620 0.476768044792919 522 6991579
SGTC_703 3875-0075 71.8 µM 0.0577374665764417 0.479525331838852 no 1621 0.476978874724356 528 2850814
SGTC_1555 citronellol 128 µM 0.057004818803357 0.47983688060852 no 1622 0.477270678267691 526 8842 A terpine precursor.
SGTC_2565 isoliquiritigenin 100 µM 0.0567982388606943 0.479924728229795 no 1623 0.477352958430381 523 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_4 0960-0234 25.671 µM 0.0560086504019169 0.480260507762392 no 1624 0.477667457978114 492 6821112
SGTC_3092 9117248 49.47 µM 0.0558077293556153 0.480345953473968 no 1625 0.477747488703534 536 17141857
SGTC_1037 k284-1091 78.7 µM 0.0548240340720089 0.480764302616931 no 1626 0.478139326386972 518 3334711
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.0537573719240466 0.481217960106655 no 1627 0.478564236328056 508 94937 An inhibitor of serotonin biosynthesis.
SGTC_2838 9002687 71.43 µM 0.0533279518936373 0.481400601793045 no 1628 0.478735304746203 513 6457060
SGTC_2104 5389443 200 µM 0.0532814232174681 0.481420391686947 no 1629 0.478753840649798 521 2244536
SGTC_1645 Cervolide 78 µM 0.0518067360977016 0.48204763913487 no 1630 0.479341344065734 519 23173 A fragrance.
SGTC_1797 st048695 56.8 µM 0.0508006703527131 0.482475587483529 no 1631 0.479742178352184 527 592262 YIL048W NEO1
SGTC_2598 perillyl alcohol 100 µM 0.0497326385799024 0.482929916293346 no 1632 0.480167723403104 523 10819 An apoptosis inducer.
SGTC_2061 5245884 80.95 µM 0.0492840378296657 0.483120752696238 no 1633 0.480346470012885 520 573863
SGTC_260 nsc-65238 3.989 µM 0.0492681625019865 0.483127506189907 no 1634 0.480352795667878 511 3246252
SGTC_2035 5154463 94.595 µM 0.0488561921178802 0.483302763433195 no 1635 0.480516950384091 533 2769623
SGTC_1827 berberine 7.24 µM 0.0486430137181579 0.483393453402202 no 1636 0.48060189526409 529 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1496 4469-0713 57.4 µM 0.0475711898097517 0.483849439713722 no 1637 0.481028996612944 530 746691
SGTC_3287 9117173 37.0625 µM 0.0469955054608033 0.484094362006893 no 1638 0.481258404847641 528 2789709
SGTC_2409 alverine citrate 63.97 µM 0.046889465505034 0.48413947688203 no 1639 0.481300662084771 455 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_449 xestospongin c 11.1929 µM 0.0463659014245223 0.484362231053968 no 1640 0.481509306995568 525 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_218 alverine citrate 93.75 µM 0.0454999789523418 0.484730654788261 no 1641 0.481854395838158 523 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2858 9025781 8.96 µM 0.045479138576457 0.484739521897672 no 1642 0.481862701347496 522 4894980 YPL153C RAD53
SGTC_2341 7987486 176.74 µM 0.0444107579316519 0.485194103751794 no 1643 0.482288493260652 527 1258686
SGTC_3028 9087778 49.47 µM 0.0439208070826109 0.485402577838405 no 1644 0.482483764824845 535 17217395
SGTC_1055 3448-0672 86 µM 0.0428478910618963 0.485859117462174 no 1645 0.482911393736966 525 748378
SGTC_2226 7298446 200 µM 0.0423072231002967 0.486089185723685 no 1646 0.483126893621023 528 3283010
SGTC_3284 9108171 64.8615 µM 0.0417304001575248 0.486334643972003 no 1647 0.483356809620794 526 8687505
SGTC_948 3448-0295 75.3 µM 0.0402140797070276 0.486979915577826 no 1648 0.483961226363725 517 678569
SGTC_211 3455-0679 143.504 µM 0.0377036286385558 0.488048314538699 no 1649 0.484961991410212 504 748649
SGTC_1077 5-fluorocytosine 377 nM 0.0374925023979907 0.48813816976154 no 1650 0.485046159082568 536 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1527 coumarin 137 µM 0.034274651504682 0.489507757344197 no 1651 0.486329069079453 534 323 A hepatotoxic, DNA x-linker.
SGTC_32 0928-0142 34.1 µM 0.0340032089439062 0.489623295107502 no 1652 0.486437295907561 529 2244242
SGTC_1391 3442-0225 151 µM 0.0323535133001619 0.490325495719509 no 1653 0.487095067037017 528 5227075
SGTC_1224 0823-0416 294 µM 0.0321515820854866 0.4904114507824 no 1654 0.487175584047277 519 3598164
SGTC_1469 k284-2957 126 µM 0.0307708628065496 0.490999186462573 no 1655 0.487726138761992 529 23884841
SGTC_395 anisomycin 6.25 µM 0.0299849528480144 0.491333736356001 no 1656 0.488039526831651 530 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2090 5301565 104.445 µM 0.0299050499494813 0.491367750147689 no 1657 0.488071389187454 525 2056344
SGTC_1356 1502-0781 85.8 µM 0.0280394090381403 0.492161950437614 no 1658 0.488815359812871 530 567702
SGTC_2555 cholic acid 100 µM 0.0261879395810695 0.492950148689877 no 1659 0.489553717702466 524 6708657 Influences liver metabolism.
SGTC_2170 morpholine 200 µM 0.0249053570757234 0.493496179577609 no 1660 0.490065227116155 536 121171 Reacts with secondary amines.
SGTC_581 0958-0271 211 µM 0.0243228892566589 0.493744156342156 no 1661 0.490297527771947 533 4591145
SGTC_869 0564-0080 44.1 µM 0.0237898608856182 0.493971087138706 no 1662 0.490510113801649 527 6843321
SGTC_1952 st077036 64.1 µM 0.0236666462837781 0.494023544641299 no 1663 0.490559255479787 519 2937007
SGTC_1343 1487-0095 224 µM 0.0214939725704026 0.49494855698105 no 1664 0.49142580577285 540 4560101 YGL055W OLE1
SGTC_2239 6685329 187.64 µM 0.020136833483329 0.495526370862622 no 1665 0.491967108612715 531 805680
SGTC_1202 1988-0068 29.6 µM 0.0193656949634513 0.495854694117131 no 1666 0.492274688363526 540 2850480
SGTC_566 0958-0068 16.5 µM 0.019297515159885 0.495883722782035 no 1667 0.492301883087875 536 6815365
SGTC_198 3454-2873 16.191 µM 0.0174666186573477 0.496663264526885 no 1668 0.493032181617289 544 710957
SGTC_203 k066-0004 30.888 µM 0.0173913944289183 0.496695293078126 no 1669 0.493062187184767 536 6795412
SGTC_3119 9125183 49.47 µM 0.0166037584267542 0.49703064956981 no 1670 0.493376363090724 541 22695334
SGTC_1530 rhein 70.4 µM 0.0161475474521964 0.497224894220035 no 1671 0.493558340534326 536 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_229 benomyl 22.8748 µM 0.0151209658582046 0.497661992535012 no 1672 0.493967837268774 534 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2517 totarol 10 µM 0.0137641492256583 0.498239702674538 no 1673 0.494509072298371 533 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_3052 9092717 49.47 µM 0.0128474758042004 0.498630009259157 no 1674 0.494874739699548 538 25237534
SGTC_1014 4130-3005 69.3 µM 0.0115412581638656 0.499186180439712 no 1675 0.495395806363223 538 743608
SGTC_1831 st055328 12 µM 0.0111226223379491 0.499364430739813 no 1676 0.495562807170181 543 1103068
SGTC_2849 9019321 12.99 µM 0.0101063206685289 0.499797160711443 no 1677 0.495968230018776 547 16489627
SGTC_329 k048-0121 21.3 µM 0.0100750691348695 0.499810467274025 no 1678 0.495980696942159 534 6832902
SGTC_2188 6126565 140.678 µM 0.00918480347310972 0.499810467274025 no 1679 0.496335845075865 543 874518
SGTC_1951 sophoraflavanone G 9.2 µM 0.00907451839580542 0.499763509090579 no 1680 0.496379840622508 533 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2920 7982904 15.77 µM 0.00784604215021637 0.499240437669822 no 1681 0.496869914167377 543 6456808
SGTC_1503 4585-0012 61.3 µM 0.00761162937115856 0.499140627455803 no 1682 0.496963428542718 538 2922052
SGTC_2701 st077767 14.721 µM 0.00670542271790302 0.498754775845592 no 1683 0.497324943416171 536 5721188
SGTC_2468 5987765 72.9 µM 0.00665736079086459 0.498734311699498 no 1684 0.497344116922975 545 26772094
SGTC_2485 5633444 17.78 µM 0.00547829326799339 0.498232281193393 no 1685 0.497814488122784 544 5724239
SGTC_1626 st003712 1.76 µM 0.00469510168292573 0.497898810638212 no 1686 0.498126932309544 543 24207035
SGTC_1498 4478-3555 97.6 µM 0.00462625629274818 0.497869497429803 no 1687 0.498154397348193 547 3437919
SGTC_1032 k061-1018 98.7 µM 0.00351739110142737 0.497397362988956 no 1688 0.49859676686641 538 4005393
SGTC_3238 9133470 49.47 µM 0.00162686081807888 0.496592418666265 no 1689 0.499350976721632 546 3534688
SGTC_2710 st078562 53.7235 µM 0.00113359531734379 0.496382399707734 no 1690 0.499547760995904 548 17250908
SGTC_2381 9035592 200 µM 0.000408075981226376 0.496073495257145 no 1691 0.499837201241991 547 4749657
SGTC_465 cgp-37157 41 µM 0.000393027502934654 0.496067088089107 no 1692 0.499843204715755 548 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2077 5212015 200 µM 7.76660865766068e-05 0.495932817367651 no 1693 0.499969015714342 547 780900
SGTC_1054 3429-0080 167 µM 1.47002338389288e-05 0.495906008592744 no 1694 0.49999413545519 547 1162877
SGTC_183 3914-0051 30.55 µM -0.000235106366575128 0.495799649398291 no 1695 0.499906206130846 548 1596232
SGTC_1519 esterone 74 µM -0.00044043907641268 0.495712225904228 no 1696 0.499824290236159 548 698 A steroid.
SGTC_180 1486-1293 102.781 µM -0.000678101837221288 0.495611037661371 no 1697 0.499729476527447 550 4140536
SGTC_18 0111-0177 500 nM -0.000787764281527775 0.495564347437479 no 1698 0.499685727553613 549 721752
SGTC_277 nystatin 15.5 µM -0.00163811691471104 0.495202300762677 no 1699 0.499346486194757 551 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_882 0843-0131 351 µM -0.00195388326812359 0.495067860870615 no 1700 0.499220513849345 551 5425421
SGTC_2603 homopterocarpin 100 µM -0.00264429521140266 0.494773914782577 no 1701 0.498945080067694 552 101795 A weak amylase inhibitor.
SGTC_1917 st066507 28.5 µM -0.00320948351174774 0.494533285346517 no 1702 0.498719603527094 543 3156428
SGTC_1908 st060353 56.5 µM -0.00346794967017253 0.494423243800582 no 1703 0.498616491023433 551 4227716
SGTC_795 0685-0265 78 µM -0.00346992384771045 0.494422403299333 no 1704 0.498615703445283 548 302754
SGTC_2870 9038528 12.99 µM -0.00391759342458889 0.494231809720738 no 1705 0.498437110343261 553 6463316
SGTC_1714 st033236 13.627 µM -0.00405992060640284 0.494171214751259 no 1706 0.498380330464524 550 2916566
SGTC_1879 gemcitabine 100 µM -0.00532292333445211 0.493633504741822 no 1707 0.497876470854396 553 60750 A nucleoside analog which inhibits DNA replication.
SGTC_290 2043-6722 48.1 µM -0.00585378706211703 0.493407498539387 no 1708 0.497664690177737 553 773758 YLR208W SEC13
SGTC_215 1287-0124 461.5 µM -0.00715249291269089 0.492854605681915 no 1709 0.497146592496054 557 5560863
SGTC_1780 st038448 24.544 µM -0.00973203281285565 0.491756470202277 no 1710 0.496117541922989 558 728868 YDL195W SEC31
SGTC_3057 9095946 49.47 µM -0.00995117976124183 0.491663179955516 no 1711 0.496030119173696 551 24540043
SGTC_393 acivicin 6.25 µM -0.0104151848078802 0.491465655808164 no 1712 0.495845017541442 554 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1727 st034309 9.9045 µM -0.0109357700948076 0.491244048287511 no 1713 0.495637345896349 561 870305
SGTC_66 0109-0187 42.4 µM -0.0117181113458656 0.490911019190952 no 1714 0.495325256922643 554 759417
SGTC_1900 st060200 72.8 µM -0.0120059686841168 0.49078848489871 no 1715 0.495210426539148 549 688945
SGTC_2091 4-phenylthiadiazole 200 µM -0.0128719820180428 0.490419848096584 no 1716 0.494864963943069 553 270010
SGTC_3175 9106517 49.47 µM -0.0132838664850119 0.490244523656629 no 1717 0.494700659866952 555 41468073
SGTC_1383 3049-0032 20.7 µM -0.0149572431204864 0.489532247000515 no 1718 0.494033145805054 568 712864
SGTC_2034 5197015 53.07 µM -0.0152630519173749 0.489402082315846 no 1719 0.493911159673254 557 780676
SGTC_209 4077-0173 175.592 µM -0.0152924339148061 0.489389576199733 no 1720 0.493899439320096 544 15993494
SGTC_1564 D-Arginine 115 µM -0.0164519447255641 0.488896051943834 no 1721 0.493436919723126 564 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1134 3477-0009 42.5 µM -0.0165431360460484 0.488857238762084 no 1722 0.493400544600216 551 3973534
SGTC_2205 7238770 200 µM -0.0186300694815765 0.487969020130502 no 1723 0.492568107509044 559 279867
SGTC_2664 lyso-paf C-16 73.48 µM -0.0187192648575551 0.487931059032224 no 1724 0.492532529906626 558 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2200 6600604 21.907 µM -0.0188210324797647 0.487887747383471 no 1725 0.492491937650699 559 2904777
SGTC_1921 5740136 50 µM -0.0192194499987781 0.487718184816173 no 1726 0.492333020806402 560 1774243
SGTC_46 0329-0187a 2.197 µM -0.0196026877122857 0.487555084718868 no 1727 0.492180159880891 556 46494817
SGTC_1901 st060216 58.6 µM -0.0201334801980557 0.487329191015474 no 1728 0.491968446108834 548 688792
SGTC_2630 antimycin a 100 µM -0.0201751354471799 0.48731146362119 no 1729 0.491951831443508 563 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2329 6138490 200 µM -0.0212085844511437 0.48687166262884 no 1730 0.491539633210943 576 720019
SGTC_1814 st052110 31.539 µM -0.0214308369699879 0.486777081530963 no 1731 0.491450987432807 564 674163
SGTC_775 4577-0580 57.3 µM -0.0218988212275808 0.486577930028905 no 1732 0.491264332537355 572 2006902
SGTC_3262 9137218 49.47 µM -0.0224667998682868 0.486336230247121 no 1733 0.491037797589442 554 17650664
SGTC_1403 3909-7815 62.9 µM -0.0224699835884588 0.486334875448845 no 1734 0.491036527789413 564 6615483
SGTC_3146 9095609 49.47 µM -0.0231727234622872 0.486035835853242 no 1735 0.490756248143695 559 17173999
SGTC_2938 9059746 27.26 µM -0.0233155985627308 0.485975038618461 no 1736 0.490699264621282 568 6471769
SGTC_2717 st081029 62.2815 µM -0.0233187021170349 0.485973717975445 no 1737 0.490698026818787 566 5292846
SGTC_3047 9092122 49.47 µM -0.0243992015823873 0.48551394682285 no 1738 0.490267092591085 563 17173831
SGTC_2437 5741531 144.16 µM -0.0260683288035669 0.4848037424785 no 1739 0.489601419213577 564 2262990
SGTC_925 2064-1272 59.6 µM -0.0260703590620462 0.484802878643711 no 1740 0.48960060953281 584 6815817
SGTC_1631 benzylvanillin 81.9 µM -0.0261655403842894 0.484762380955536 no 1741 0.489562650628067 568 75506
SGTC_2893 9048488 25.97 µM -0.0262609540902361 0.484721784550641 no 1742 0.489524599142137 555 6467338
SGTC_1203 3992-3522 103 µM -0.0262921958097315 0.484708491929839 no 1743 0.489512139801389 559 5322312
SGTC_444 curcumin 90.4 µM -0.0267433574138236 0.484516535123383 no 1744 0.48933221563553 562 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_100 0086-0128 49.5915 µM -0.0268854012424745 0.484456100136573 no 1745 0.489275568715198 566 93297
SGTC_1672 st016598 6.51 µM -0.0270423987338954 0.484389303272568 no 1746 0.489212958542577 583 4665860 YNL267W PIK1
SGTC_1367 1812-0510 76.9 µM -0.0288525070299766 0.48361919851318 no 1747 0.488491111867553 565 1142582 YDR527W RBA50
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.0295029982121125 0.483342463904777 no 1748 0.48823171387815 574 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_333 3486-0131 40.1 µM -0.0297130738903097 0.483253094361805 no 1749 0.488147942534715 555 6744690
SGTC_1571 st070080 73.4 µM -0.0297812545806867 0.483224089389675 no 1750 0.488120754406586 561 4315245
SGTC_2261 9010538 184.68 µM -0.0300078859435085 0.483127678033801 no 1751 0.488030381965371 584 6457250
SGTC_1192 1488-0095 21.4 µM -0.0303586225767955 0.482978472942666 no 1752 0.487890522016519 572 915875
SGTC_1888 azatryptophan 97.5 µM -0.031749502987003 0.482386809239536 no 1753 0.487335908545158 569 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2246 7293507 91.5585 µM -0.0318713249213125 0.48233498949078 no 1754 0.487287333207881 557 887656
SGTC_1244 0416-0015 52.5 µM -0.0318984806347491 0.482323438227012 no 1755 0.487276505151192 568 96201
SGTC_2932 9016711 44.54 µM -0.0320598712424753 0.482254787585187 no 1756 0.487212152528268 576 7117328
SGTC_57 miconazole 162.5 nM -0.0322898882891828 0.482156946259281 no 1757 0.487120436488886 564 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1550 gossypolone 36.6 µM -0.0335705993934573 0.481612195698883 no 1758 0.486609783666571 560 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2461 5755302 26.15 µM -0.0336329213084852 0.48158568793559 no 1759 0.486584934851765 566 2788904
SGTC_2805 7950783 58.44 µM -0.0337786446664353 0.481523706841747 no 1760 0.486526832656828 565 1178958 YDL195W SEC31
SGTC_147 4466-0538 29.23 µM -0.0353404517058458 0.480859445607041 no 1761 0.485904133833308 592 6742687 YHR072W ERG7
SGTC_2987 9018338 71.43 µM -0.0364628785673181 0.480382092424386 no 1762 0.485456638812814 565 5055682
SGTC_1876 myriocin 605 nM -0.0375534095593309 0.47991833106705 no 1763 0.48502187774048 563 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1999 st074831 12.5 µM -0.0375864944579261 0.479904261739585 no 1764 0.48500868808748 586 17112523
SGTC_2016 5121758 140 µM -0.0382229560897062 0.479633611818411 no 1765 0.484754958977435 573 2795203
SGTC_2979 9012552 45.46 µM -0.0391270460215162 0.479249171400395 no 1766 0.484394548934123 567 17100905
SGTC_1106 tegaserod maleate 11.7 µM -0.040685117981766 0.478586687859923 no 1767 0.483773462951263 573 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2780 5215298 71.43 µM -0.0410141007166172 0.478446813731753 no 1768 0.48364232728748 580 2834131
SGTC_1235 benzylparaben 21.5 µM -0.0411036172767458 0.478408754287992 no 1769 0.483606645436306 575 7180
SGTC_2088 5278280 127.392 µM -0.0415526535684894 0.478217842071434 no 1770 0.483427658796798 565 791502
SGTC_644 1498-1197 63.3 µM -0.0433952903226335 0.477434479657033 no 1771 0.482693215972322 574 6741615
SGTC_1778 st046819 58.9 µM -0.0439744819253592 0.477188265089655 no 1772 0.482462372329344 566 671715
SGTC_872 0588-0139 234 µM -0.0441140158547161 0.477128950462013 no 1773 0.482406760312347 565 2047100
SGTC_2909 7941780 10.49 µM -0.0478433841776126 0.475543821195111 no 1774 0.480920530275602 584 1243215
SGTC_2532 xanthone 78.9 µM -0.0489831654053246 0.475059445075422 no 1775 0.480466355947174 577 7020 An insecticide.
SGTC_776 4476-4378 112 µM -0.0490207333856428 0.475043480325905 no 1776 0.480451386474511 573 2892008
SGTC_643 k048-0106 28.4 µM -0.0516267410061706 0.473936140215591 no 1777 0.479413055752967 581 6763920
SGTC_663 1486-0733 13.9 µM -0.0537346910646109 0.473040580739264 no 1778 0.478573271622574 574 722445 YPR165W RHO1
SGTC_2795 7780010 54.55 µM -0.0540689934092277 0.472898565281959 no 1779 0.478440097886137 573 953673
SGTC_482 fipronil 114 µM -0.0547264394345167 0.472619284761278 no 1780 0.478178202649684 565 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_634 1611-4317 11.2 µM -0.0548147108812094 0.472581788415137 no 1781 0.478143040217442 580 2843522
SGTC_2851 9015922 71.43 µM -0.0548766144024604 0.472555492901081 no 1782 0.478118381400853 569 2996893
SGTC_1487 3970-0795 2.82 µM -0.0551241451908229 0.472450347424307 no 1783 0.478019780153215 568 3765103
SGTC_2312 7706453 155.7 µM -0.0564407865699247 0.471891100405234 no 1784 0.477495332868848 581 976098
SGTC_3335 9143315 29.6265 µM -0.0570225488521113 0.471644012875165 no 1785 0.477263616488311 576 4899691
SGTC_2591 skatole 100 µM -0.0576680039946444 0.47136988632976 no 1786 0.477006540189231 581 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_134 0269-0018 6.916 µM -0.0578425535919695 0.47129575696807 no 1787 0.476937021018247 569 4378915
SGTC_1153 4055-0057 267 µM -0.0583108904371067 0.471096864200863 no 1788 0.476750496481184 572 882706
SGTC_995 3931-2021 34.6 µM -0.0592477237007518 0.470699032581326 no 1789 0.476377399180164 583 730143
SGTC_230 MPP+ 141.667 µM -0.0593412901014919 0.470659300672059 no 1790 0.47634013714815 592 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_409 arachidonic acid 100 µM -0.0609861855730138 0.469960862550977 no 1791 0.475685105445914 574 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_3033 9090887 49.47 µM -0.0627248250409021 0.469222720347514 no 1792 0.474992814395067 570 19325384
SGTC_3272 9137413 49.47 µM -0.0628911894548199 0.469152095570571 no 1793 0.474926575376768 610 17614870
SGTC_1226 3909-7979 35.4 µM -0.0629343705061729 0.469133764572568 no 1794 0.474909382687847 575 6615510
SGTC_2122 5258151 111.688 µM -0.0641472091331899 0.468618923421624 no 1795 0.474426505885457 588 2173356
SGTC_2994 9053520 71.4286 µM -0.06458001211795 0.46843521437071 no 1796 0.474254199751088 595 4647384
SGTC_1705 st027868 56.3335 µM -0.0661484996406687 0.467769505335803 no 1797 0.473629799123067 585 292948
SGTC_690 glyoxal 20.3 µM -0.0666703519147766 0.467548036837202 no 1798 0.473422068762017 586 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_3142 9086498 49.47 µM -0.0672259364297691 0.467312263779402 no 1799 0.473200918770336 590 25236367
SGTC_261 5-fluorouridine 15.376 µM -0.0676608485646727 0.467127708383022 no 1800 0.473027808087464 575 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1696 st025591 34.7925 µM -0.068029678318998 0.466971200646562 no 1801 0.472881004560952 580 2787147
SGTC_1458 k015-0034 6.33 µM -0.0688073006603452 0.466641244267425 no 1802 0.472571503388368 611 3598957
SGTC_2942 9052777 62.25 µM -0.069386191896118 0.466395627236453 no 1803 0.472341109849748 571 6469503
SGTC_2416 tofa 880 nM -0.069890649229566 0.466181602103719 no 1804 0.472140347882108 581 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_70 0141-0289 43.283 µM -0.0698995904713215 0.466177808708477 no 1805 0.472136789545178 576 352408
SGTC_1212 0520-0165 585 µM -0.0719405314445414 0.465312003819734 no 1806 0.47132461708381 614 5403258
SGTC_90 0870-0863 4.608 µM -0.0727157111279551 0.464983201067935 no 1807 0.471016172987574 592 1738164
SGTC_1773 st048542 73.5835 µM -0.0743740457905465 0.464279876973417 no 1808 0.470356380026318 587 3237138
SGTC_720 r052-1644 49.9 µM -0.0748572136039961 0.464074979302402 no 1809 0.470164159796654 589 1422863 YOR257W CDC31
SGTC_583 1488-1091 88.9 µM -0.0762601408210934 0.463480092125277 no 1810 0.469606068239113 600 4303273
SGTC_2646 retinol 96.75 µM -0.0778637587294451 0.462800205591285 no 1811 0.468968214099105 593 445354 A vitamin A analog and teratogen.
SGTC_863 0466-0191 129 µM -0.0781514331700927 0.462678251579208 no 1812 0.4688537972561 583 765160 YPR165W RHO1
SGTC_35 0133-0054 64.071 µM -0.078308693509046 0.462611585584076 no 1813 0.468791251140373 595 99677
SGTC_1422 4031-0024 15.5 µM -0.079283040571643 0.462198562668532 no 1814 0.4684037477491 591 782427
SGTC_1757 st041620 31.8375 µM -0.0798553443623213 0.461955983710818 no 1815 0.46817615319419 581 5289815
SGTC_2763 lisinopril 49.32 µM -0.0799130115998089 0.461931541429802 no 1816 0.468153220583845 598 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_899 1083-0020 478 µM -0.0804196935786326 0.461716790267535 no 1817 0.467951732210299 591 767123
SGTC_3140 9094243 49.47 µM -0.0805181256975655 0.461675072271263 no 1818 0.467912590408078 589 19291112
SGTC_822 1487-0950 154 µM -0.0807033842644578 0.461596556196667 no 1819 0.467838922672223 582 1958375
SGTC_2160 5660466 132.927 µM -0.0813242565027467 0.46133342976358 no 1820 0.467592041988859 609 2859134
SGTC_3290 9121031 71.43 µM -0.0814573409607522 0.461277030602349 no 1821 0.467539124537158 574 17014854
SGTC_949 1165-0505 146 µM -0.0817913358566405 0.461135492097556 no 1822 0.467406322987385 580 6244267
SGTC_294 k038-0071 157 µM -0.0821328227403448 0.460990783769657 no 1823 0.467270546257979 589 24152826
SGTC_2072 5231554 129 µM -0.0821938009419495 0.460964944217411 no 1824 0.467246301449496 584 789545
SGTC_1648 st011736 69.8 µM -0.0843336412829279 0.460058290641466 no 1825 0.466395582893881 584 2855514
SGTC_1259 0671-0132 43 µM -0.0856591332041982 0.459496781563033 no 1826 0.465868694825482 602 X1259
SGTC_1463 k081-0032 34.1 µM -0.0865677562901069 0.459111914379353 no 1827 0.465507548203413 588 977755
SGTC_2690 usnic acid 100 µM -0.0892345361683634 0.457982564030438 no 1828 0.464447759477093 607 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1500 4488-1866 171 µM -0.0898174339063077 0.457735758448681 no 1829 0.464216146965629 603 2900003
SGTC_2 0422-0095 29 µM -0.0898575783858176 0.45771876141478 no 1830 0.464200196133288 570 6790840
SGTC_2722 naftopidil 47.16 µM -0.0908874872470863 0.457282728088368 no 1831 0.463790996385092 604 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2810 7959871 45.46 µM -0.0919163993504905 0.456847168101919 no 1832 0.463382230911169 597 2974535
SGTC_2628 lathosterol 100 µM -0.09208257190805 0.456776828635387 no 1833 0.463316217609326 607 6710616
SGTC_1291 0993-0025 5.79 µM -0.0923935447317994 0.456645200056351 no 1834 0.46319268402487 600 4353356
SGTC_2556 citropten 84.59 µM -0.0934104213127434 0.456214809816214 no 1835 0.462788755853895 583 2775 A potential DNA crosslinker.
SGTC_799 1310-0557 151 µM -0.0934982615927161 0.456177634060311 no 1836 0.46275386534731 629 5354492
SGTC_656 4090-1979 187 µM -0.0952211096114968 0.455448568419551 no 1837 0.462069601561942 590 22330961
SGTC_3322 9139058 2.11 µM -0.0954469026075084 0.455353029608922 no 1838 0.461979931602648 581 4908926 YPR165W RHO1
SGTC_1103 duloxetine 36.1 µM -0.0961480185872907 0.455056385927681 no 1839 0.461701507307371 603 60835 A selective serotonin reuptake inhibitor.
SGTC_1221 2958-7315 257 µM -0.0964031841311661 0.454948431047508 no 1840 0.461600181666784 602 4562705
SGTC_2060 5238662 140 µM -0.0965264901694318 0.454896264190433 no 1841 0.46155121802027 609 790130
SGTC_595 3909-8003 73.7 µM -0.0977544411851656 0.454376799818915 no 1842 0.461063642355603 595 699517
SGTC_2892 9047358 58.44 µM -0.098087216877048 0.454236037965425 no 1843 0.460931519015252 605 6466771
SGTC_736 0958-0254 92.6 µM -0.0980981810258126 0.454231400302804 no 1844 0.460927165946203 600 6812352
SGTC_1002 4049-0206 172 µM -0.0998219623453808 0.453502345909014 no 1845 0.460242835852268 585 4662749
SGTC_114 0364-0001 490.298 µM -0.101206799406161 0.452916757645133 no 1846 0.459693149644891 597 4003655
SGTC_1663 st014140 55.4 µM -0.104636632862423 0.451466871465378 no 1847 0.458332072714493 613 4207120
SGTC_2983 9022671 12.99 µM -0.104994529214668 0.451315615661816 no 1848 0.458190074890412 620 6405161
SGTC_890 0929-0006 47.2 µM -0.105070844824013 0.451283363721297 no 1849 0.458159796840343 605 1378169
SGTC_3127 9126946 49.47 µM -0.107052267188936 0.450446102782015 no 1850 0.45737375736824 605 27243249
SGTC_2824 7998404 51.95 µM -0.107293739137289 0.450344082477282 no 1851 0.457277975658203 584 837851
SGTC_3172 9105863 49.47 µM -0.107489570808938 0.450261347297438 no 1852 0.457200299337851 595 2348785
SGTC_1381 2324-0066 62.1 µM -0.108735869655918 0.449734860392026 no 1853 0.456705995325078 618 10885928
SGTC_2587 piperic acid 92.2 µM -0.108863504390845 0.449680947309832 no 1854 0.456655376915725 599 5370536
SGTC_1719 st032227 49.2 µM -0.109440912439381 0.449437061000003 no 1855 0.45642639258941 590 3125804
SGTC_3235 9132602 49.47 µM -0.110001648904697 0.449200234733327 no 1856 0.456204033607725 607 4912240
SGTC_2910 7948405 25.97 µM -0.110180518594003 0.449124693171647 no 1857 0.45613310605371 582 2971328
SGTC_2779 methotrexate 400 µM -0.110292743308579 0.449077298546745 no 1858 0.456088606077693 609 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_762 1165-0429 115 µM -0.111896522391993 0.448400071938983 no 1859 0.455452727008413 591 5967793
SGTC_111 0083-0039 52.457 µM -0.111924428445839 0.448388289395321 no 1860 0.455441663599833 589 759313
SGTC_1699 st031318 29.054 µM -0.111961066195332 0.448372820208726 no 1861 0.455427138546229 608 5340658
SGTC_169 k015-0017 16.025 µM -0.112390636834487 0.448191452802414 no 1862 0.455256839507237 619 1840002
SGTC_2054 5233173 129 µM -0.112621619076204 0.448093935132025 no 1863 0.455165272274903 600 6889
SGTC_1348 1493-0373 93.8 µM -0.114627995737007 0.447247001830068 no 1864 0.454369994289431 607 3010129
SGTC_1159 4092-0538 61.2 µM -0.11711510955218 0.446197473627365 no 1865 0.453384418221302 597 717301
SGTC_1980 st071811 45.7 µM -0.117902410653454 0.445865321443387 no 1866 0.453072491573814 612 4974850
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.117967230463428 0.445837976490685 no 1867 0.453046811421198 616 5282309
SGTC_2992 9074591 71.4286 µM -0.119476861598296 0.445201195063883 no 1868 0.452448785242851 588 17741321
SGTC_1404 3909-7820 48.3 µM -0.119774015354261 0.445075868467031 no 1869 0.452331083238658 602 23741373
SGTC_3279 9140807 49.47 µM -0.123290230474342 0.443593301255567 no 1870 0.450938638381799 590 45595718
SGTC_358 0075-0058 9.45 µM -0.123737304481707 0.443404854326224 no 1871 0.450761636957629 678 1069125
SGTC_1744 st037937 38.9 µM -0.124084545635251 0.443258496942596 no 1872 0.450624167191706 631 1016152
SGTC_3037 9091026 49.47 µM -0.124149059585732 0.443231306049394 no 1873 0.4505986273293 626 25236398 YIL048W NEO1
SGTC_109 0132-0036 33.701 µM -0.124370915960452 0.443137801601631 no 1874 0.450510800115544 581 67274 A color developer.
SGTC_2653 dihydrofissinolide 100 µM -0.125024458962856 0.442862375256231 no 1875 0.450252093405407 597 6857746
SGTC_1707 st032323 6.317 µM -0.126622303336648 0.44218910314433 no 1876 0.449619671758862 603 3132057 YMR211W DML1
SGTC_1243 0416-0003 5.65 µM -0.127788157236396 0.44169796096735 no 1877 0.449158311189019 630 2141977
SGTC_1880 MG-132 525 µM -0.12859193699388 0.441359402816512 no 1878 0.448840273341071 603 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.12903997699692 0.441170703538928 no 1879 0.448663008090055 618 521171
SGTC_1649 st011737 51.3 µM -0.129835514904125 0.440835682845472 no 1880 0.448348281946699 601 1761035
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.12995146012632 0.440786858973442 no 1881 0.448302415072371 605 91467 include heat shock
SGTC_1821 st053465 65.6 µM -0.130495273588493 0.440557874247899 no 1882 0.448087296649686 624 675086
SGTC_785 1270-0111 65.3 µM -0.130556955554601 0.440531902940983 no 1883 0.448062897835357 599 6741994
SGTC_864 0469-0573 172 µM -0.130676302665005 0.440481652343909 no 1884 0.44801568965191 634 689425
SGTC_504 lovastatin 124 µM -0.130922284820495 0.440378085620149 no 1885 0.447918392839197 645 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1903 st060211 78.3 µM -0.13109450865154 0.440305576047789 no 1886 0.447850272567815 593 688960
SGTC_2347 9049783 174.81 µM -0.131136116156057 0.440288058781736 no 1887 0.447833815642142 637 6467988 YPL169C MEX67
SGTC_867 0518-0118 155 µM -0.131445667245282 0.44015773767522 no 1888 0.447711382394721 616 6848158
SGTC_259 usnic acid 108.925 µM -0.132224864666076 0.439829724042701 no 1889 0.447403217314075 655 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2006 4011487 200 µM -0.133210155370274 0.43941501182572 no 1890 0.447013589801362 604 45595294
SGTC_1862 st057513 3.81 µM -0.135865359829029 0.438297759449884 no 1891 0.445963860172254 604 5393163
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.136836048206714 0.437889437096758 no 1892 0.445580194641819 611 6708739 YPR165W RHO1
SGTC_303 1348-1668 34.2 µM -0.137162353561686 0.437752190809118 no 1893 0.445451233557543 606 5380509
SGTC_2506 ethyl hematommate 54.16 µM -0.137164663599189 0.437751219218053 no 1894 0.445450320614411 613 3940691 An allergen.
SGTC_1579 chlormadinone acetate 49.4 µM -0.137881390671902 0.437449785284944 no 1895 0.445167079006758 639 45114258 A steroidal progestin.
SGTC_1766 st045414 44.774 µM -0.138018721491292 0.437392032195667 no 1896 0.445112810769198 599 253960
SGTC_1501 4491-0275 38.4 µM -0.138879133182757 0.437030225155465 no 1897 0.444772830232996 610 5104718
SGTC_2764 methyldopa 94.69 µM -0.139192830067712 0.43689832726839 no 1898 0.444648887064022 633 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1234 0326-0494 15.5 µM -0.140996810715056 0.436139957011959 no 1899 0.44393623092727 626 1547813
SGTC_135 0933-0004 26.348 µM -0.141120350060358 0.43608803121611 no 1900 0.44388743375356 596 21230617 YGL099W LSG1
SGTC_2319 6033012 152.6 µM -0.14121862903123 0.436046723594009 no 1901 0.443848614857877 600 847246
SGTC_2726 cimetidine 79.27 µM -0.141306932665777 0.436009609299244 no 1902 0.44381373654781 617 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2149 5554786 194.827 µM -0.142683580194029 0.435431073092522 no 1903 0.443270042564339 609 745063 YPR165W RHO1
SGTC_1389 3405-0187 19 µM -0.143042252504704 0.435280363671893 no 1904 0.443128405805608 614 799890
SGTC_2293 7624732 200 µM -0.143593082586234 0.435048930377184 no 1905 0.442910901671637 599 894453
SGTC_3088 9117578 49.47 µM -0.144004193694284 0.434876215020987 no 1906 0.442748579033256 599 678341
SGTC_3186 9110464 49.47 µM -0.144384157820161 0.434716596135051 no 1907 0.442598562977998 620 17018021
SGTC_1152 3909-8331 15.9 µM -0.14462776714059 0.434614264047954 no 1908 0.442502386359797 615 16001939
SGTC_56 0957-0365 83.25 µM -0.144981613834698 0.434465632749556 no 1909 0.44236269421797 597 6752360
SGTC_1957 st077035 62.4 µM -0.145428492339601 0.434277937204235 no 1910 0.442186285077053 616 705593
SGTC_2971 9092186 9.93 µM -0.145872578358358 0.434091429220141 no 1911 0.44201098965106 594 25236400
SGTC_1443 4112-3303 14 µM -0.146746142530733 0.43372459113964 no 1912 0.441666198176105 601 704433
SGTC_1660 st012960 28.1 µM -0.14686757996764 0.433673600111987 no 1913 0.441618270911231 623 24207266
SGTC_2135 5326629 150.42 µM -0.147630592213815 0.433353240029674 no 1914 0.441317155271062 614 5020077
SGTC_2474 5321570 43.32 µM -0.149409998777493 0.432606304761133 no 1915 0.440615061202959 607 2841384
SGTC_1161 k007-0610 110 µM -0.150030934756758 0.432345713167102 no 1916 0.440370104535924 619 5843850
SGTC_1936 st074407 74.3 µM -0.15043793963336 0.432174919166449 no 1917 0.440209555175932 600 809813
SGTC_3288 9119690 36.221 µM -0.150478236928207 0.432158009649762 no 1918 0.440193659819951 634 17595618 YKL019W RAM2
SGTC_1860 st056228 74.6 µM -0.15187084017972 0.431573723220227 no 1919 0.439644403820255 629 688679
SGTC_749 1000-0129 128 µM -0.152118660017993 0.431469762546426 no 1920 0.439546673457529 646 708470
SGTC_308 4092-1169 104 µM -0.152633806325919 0.431253673344598 no 1921 0.439343531882245 616 2268590 YDL196W YDL196W
SGTC_2825 7998094 58.44 µM -0.152847336237678 0.4311641096572 no 1922 0.439259333681798 641 2987815
SGTC_968 1309-0633 340 µM -0.153690336806289 0.430810553344223 no 1923 0.438926952182905 621 3761976
SGTC_1502 4534-4282 27.7 µM -0.154855467654828 0.430321986206794 no 1924 0.438467630856146 650 3278949
SGTC_140 0062-0056 502.533 µM -0.157359146234049 0.429272495852572 no 1925 0.437480904426517 620 3758964
SGTC_2687 chenodiol 100 µM -0.157933777421864 0.42903169256893 no 1926 0.437254490768277 611 5702181 A cholesterol synthesis inhibitor.
SGTC_483 fpl-64176 144 µM -0.158161861654014 0.4289361195673 no 1927 0.43716462771259 612 3423
SGTC_2856 9022925 19.48 µM -0.159116834777377 0.428536007232852 no 1928 0.436788412480511 622 4944862
SGTC_1098 clofazimine 15.1 µM -0.159525776540218 0.42836469223474 no 1929 0.436627325804965 611 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_3216 9129716 49.47 µM -0.159990434429062 0.428170052869781 no 1930 0.436444304687203 608 8056934
SGTC_1567 st069303 68.4 µM -0.160384236114402 0.428005107958614 no 1931 0.436289203315336 635 5581319
SGTC_33 0986-0033 35.816 µM -0.16041618782541 0.42799172544856 no 1932 0.436276619354107 602 2848082
SGTC_1200 1643-0193 18.4 µM -0.164085999446508 0.426455233015426 no 1933 0.434831721625403 641 5403974
SGTC_1928 4'-methoxychalcone 40.3 µM -0.16435618233648 0.426342155491169 no 1934 0.434725377927645 622 641818
SGTC_1127 asiatic acid 681.4 nM -0.165820768171451 0.42572929948002 no 1935 0.434149000874608 623 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1454 4239-0054 42.6 µM -0.166219825866574 0.425562344801817 no 1936 0.43399197884734 627 1340767
SGTC_208 k072-0098 12.366 µM -0.167116318584403 0.425187325808931 no 1937 0.433639263101061 626 5948901
SGTC_1468 k284-1086 134 µM -0.167477838390091 0.425036114717732 no 1938 0.433497041824143 625 15996457
SGTC_971 1315-0384 26.7 µM -0.167614908360392 0.424978786025116 no 1939 0.433443120981184 648 6769120
SGTC_1507 4075-3230 155 µM -0.168251716246588 0.424712465773991 no 1940 0.433192628558766 611 659771
SGTC_2737 bleomycin 30.5 nM -0.1706155717235 0.423724176171509 no 1941 0.432263026498419 610 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2525 harmine 47.85 µM -0.17101882136315 0.423555631756683 no 1942 0.432104483153367 613 5280953 A monoamine oxidase inhibitor
SGTC_727 3032-0951 202 µM -0.172833744638667 0.422797230098532 no 1943 0.431391055893369 632 3652836
SGTC_2387 9077560 195.08 µM -0.173006596170683 0.422725015535465 no 1944 0.43132312140717 610 5303272
SGTC_2375 9072683 200 µM -0.17312181492055 0.422676880455132 no 1945 0.431277839011024 625 16798029
SGTC_390 dec-rvkr-cmk 16.7 µM -0.173189485987038 0.422648609967713 no 1946 0.431251243864511 635 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1531 st059297 52.4 µM -0.173460628615391 0.422535340528681 no 1947 0.431144686266815 623 7566702
SGTC_2037 5169046 200 µM -0.174700191037459 0.422017596840968 no 1948 0.430657608828642 638 5718022
SGTC_1817 st052116 64.4 µM -0.175001442379416 0.421891789708008 no 1949 0.430539250110359 627 4361398
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.175395713335714 0.421727148216538 no 1950 0.430384354320247 618 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_415 dibenzyl ketone 100 µM -0.176157125895684 0.421409232780768 no 1951 0.430085251286579 637 7593
SGTC_2018 5133068 143 µM -0.176567177343715 0.421238043673807 no 1952 0.429924188818443 631 785362
SGTC_3199 9111318 49.47 µM -0.177294864133271 0.420934284196449 no 1953 0.429638392359949 632 8548020
SGTC_2887 9044784 58.44 µM -0.177869203681395 0.420694569929399 no 1954 0.429412848524389 622 6465546
SGTC_744 1594-0068 283 µM -0.178114714525196 0.420592109106977 no 1955 0.429316443144104 620 668392
SGTC_2557 derrustone 83.84 µM -0.178582423529147 0.420396931605367 no 1956 0.429132798305374 684 629853 An antioxidant.
SGTC_2831 7999036 19.48 µM -0.180304208129905 0.419678590554139 no 1957 0.428456876101802 676 2988270
SGTC_2397 5161689 200 µM -0.180574517589534 0.419565839722087 no 1958 0.428350779530278 652 2259942
SGTC_154 3389-1638 511.116 µM -0.181115026561654 0.419340403730907 no 1959 0.428138645079415 696 5238686
SGTC_2642 cholecalciferol 100 µM -0.18146786720061 0.419193254902326 no 1960 0.428000176328542 649 9821465 A vitamin D precursor, similar to steriods.
SGTC_2256 7954252 200 µM -0.181860364727889 0.419029580825406 no 1961 0.427846155048902 647 2972920
SGTC_2154 5570129 200 µM -0.182092059091419 0.418932969311742 no 1962 0.427755240240344 632 673366
SGTC_688 0527-0193 473 µM -0.18220233910986 0.418886986657798 no 1963 0.427711968688465 621 4007154
SGTC_1690 st023502 41.2 µM -0.182556374160739 0.418739374739888 no 1964 0.427573058684646 610 24207482
SGTC_1174 0739-0097 51.1 µM -0.185025184139495 0.41771034448166 no 1965 0.426604641258473 637 728447
SGTC_1764 st044502 93.5 µM -0.1856813036039 0.417436960287517 no 1966 0.426347345452322 624 8407
SGTC_3265 9137266 49.47 µM -0.186683501043818 0.41701945343618 no 1967 0.425954396468616 635 17224265
SGTC_2921 7974240 10.71 µM -0.18742188100876 0.41671191051311 no 1968 0.425664934001884 650 2979074 YDR527W RBA50
SGTC_978 1416-0512 87.4 µM -0.188569208463207 0.416234137908725 no 1969 0.425215233947101 640 6814003
SGTC_3253 9135987 49.47 µM -0.189224435052558 0.415961342490915 no 1970 0.424958458602095 644 4182430
SGTC_298 1391-0729 10 µM -0.189942873286794 0.415662276230551 no 1971 0.424676947974012 625 3237558
SGTC_1341 1486-1360 280 µM -0.190231427958411 0.415542172522024 no 1972 0.424563892403527 633 3976547
SGTC_1258 0671-0043 57.1 µM -0.191449528497195 0.41503525553553 no 1973 0.424086709743727 673 4298767
SGTC_2221 6807166 181.081 µM -0.193180446378995 0.414315171187183 no 1974 0.423408825911959 639 674925
SGTC_2114 5491910 81.25 µM -0.194374870844732 0.413818442810072 no 1975 0.42294118241415 650 2849228
SGTC_425 3825-7017 13.1 µM -0.194460234114287 0.41378294783655 no 1976 0.422907764961982 638 3397440
SGTC_271 rotenone 740 µM -0.194953119791979 0.413578014409258 no 1977 0.422714824169315 633 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.196252162650138 0.413038007537859 no 1978 0.42220640094886 638 364106
SGTC_1786 berberine 21.6 µM -0.196642055422406 0.412875962735741 no 1979 0.422053828816119 660 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1456 k015-0012 13 µM -0.197701629348687 0.412435664294119 no 1980 0.42163925742084 654 2989616
SGTC_2836 9010338 19.48 µM -0.198400064504736 0.412145494721695 no 1981 0.421366033489704 628 2994051
SGTC_433 pimozide 108 µM -0.199294970386255 0.41177377027342 no 1982 0.421016006655892 635 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2961 9083290 32.55 µM -0.199952186439975 0.411500827409278 no 1983 0.420758987793609 655 17741490
SGTC_2472 5377652 49.4 µM -0.201884258999823 0.410698683089744 no 1984 0.420003604100953 670 1610903
SGTC_1189 1431-2119 7.28 µM -0.203635529080094 0.409971925540443 no 1985 0.419319163324034 639 3107275
SGTC_2370 9071495 200 µM -0.204591205055434 0.40957546089162 no 1986 0.418945763703565 668 21791103
SGTC_490 phenamil 164 µM -0.204765800872677 0.4095030393416 no 1987 0.418877553885957 640 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1796 st049173 110.4 µM -0.205379860021616 0.409248354947292 no 1988 0.418637677129632 640 94134
SGTC_1565 sinapyl alcohol 95.1 µM -0.207701315182374 0.408285865675462 no 1989 0.417731095353326 638 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1375 2910-0797 186 µM -0.207759037514329 0.408261940672319 no 1990 0.417708559000471 635 742508
SGTC_2729 fluphenazine 10.66 µM -0.20788694672299 0.408208925525976 no 1991 0.417658620763913 638 3372 An atypical antipsychotic.
SGTC_902 1120-0002 2.07 µM -0.208061061785728 0.408136761916959 no 1992 0.417590644999692 657 3280475
SGTC_3202 9113761 49.47 µM -0.210501373931618 0.407125680750056 no 1993 0.416638189721178 665 4798415
SGTC_1236 0330-0013 258 µM -0.21059120697335 0.407088472481636 no 1994 0.416603137133045 660 4617066
SGTC_2993 9054257 71.4286 µM -0.211078067905674 0.406886832407752 no 1995 0.416413176974638 654 6470217 YGL055W OLE1
SGTC_3303 9125618 40.5795 µM -0.212248688063783 0.406402105264087 no 1996 0.415956512168271 654 22695467
SGTC_3043 9092303 49.47 µM -0.212366786921238 0.406353211168305 no 1997 0.41591044750064 650 25236084
SGTC_145 3737-0113 38.366 µM -0.212429454179368 0.406327266896181 no 1998 0.415886004495218 641 6849351
SGTC_2314 7727897 200 µM -0.213491581012072 0.405887608567985 no 1999 0.41547177756937 632 900724
SGTC_2466 5983409 37.09 µM -0.213586616118699 0.405848275373782 no 2000 0.415434718676 650 2879657
SGTC_745 0469-0705 296 µM -0.213998283042255 0.405677905369689 no 2001 0.415274198051042 660 3486736
SGTC_3346 9158254 43.5805 µM -0.217097305617931 0.404395938102611 no 2002 0.414066256850829 639 17639500
SGTC_3170 9103054 49.47 µM -0.217193464223992 0.404356176677531 no 2003 0.414028788957739 672 16432970
SGTC_3264 9137442 49.47 µM -0.218124513396066 0.403971240527657 no 2004 0.413666049145355 662 17015726
SGTC_2919 7978188 46.38 µM -0.218842741893343 0.403674357188145 no 2005 0.413386275278552 615 2980291
SGTC_1088 bifonazole 369 nM -0.219043006652587 0.403591586635022 no 2006 0.413308273333618 639 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_3328 9140624 29.0385 µM -0.219135636401299 0.403553303698276 no 2007 0.413272195748866 649 4904392
SGTC_682 0kpi-0099 17 µM -0.221414762033123 0.402611656118667 no 2008 0.412384749608364 658 1714895 YML126C ERG13
SGTC_1923 st058458 19.1 µM -0.222588408606548 0.402126970150586 no 2009 0.41192792936609 693 3534982
SGTC_3007 9078383 71.4286 µM -0.223585350563784 0.401715376812542 no 2010 0.411539981835371 657 6496995
SGTC_93 0109-0045 59.227 µM -0.224477500285212 0.401347139962963 no 2011 0.411192886194826 635 88733
SGTC_1411 3909-8223 150 µM -0.225788860965761 0.40080603192653 no 2012 0.410682820521406 656 X1411
SGTC_1087 pterostilbene 9.05 µM -0.226043179586099 0.400701114181883 no 2013 0.410583918435268 644 5281727 Similar to reservatol, lowers cholesterol.
SGTC_97 0535-0701 19.132 µM -0.226897944381657 0.400348538214689 no 2014 0.410251550259254 628 2832013 YGL099W LSG1
SGTC_689 0833-0039 98 µM -0.227574766880648 0.400069418006679 no 2015 0.409988419177174 684 5374726
SGTC_1331 1472-0049 76.2 µM -0.227839402530867 0.399960296680684 no 2016 0.409885546695326 641 24051409
SGTC_476 mead acid 10 µM -0.228483506080061 0.399694736123911 no 2017 0.409635188636211 646 5312531 An omega 9 fatty acid.
SGTC_3018 9082602 49.47 µM -0.228872017210078 0.399534577420326 no 2018 0.409484195176971 647 17332089
SGTC_1050 3232-1156 69.3 µM -0.229264362247829 0.399372855392946 no 2019 0.409331725308316 643 700529
SGTC_2263 7948595 193.29 µM -0.230275474371249 0.398956161316251 no 2020 0.408938858582176 655 2971371
SGTC_1137 ixabepilone 100 µM -0.230876832969831 0.398708387220107 no 2021 0.408705244578206 616 154225 A novel microtubule stabilizer.
SGTC_2095 5432005 200 µM -0.231186244929955 0.398580918005058 no 2022 0.408585057769651 652 783734
SGTC_1068 loratadine 26.9 µM -0.232839467900627 0.397900019277915 no 2023 0.407943032057167 665 3957 A H1 histamine antagonist.
SGTC_2488 5268135 45.7 µM -0.233310423337554 0.397706107713821 no 2024 0.407760182637875 679 1270356 YLR208W SEC13
SGTC_2882 9058044 58.44 µM -0.233993500918254 0.39742490173055 no 2025 0.407495012070349 668 18076804
SGTC_1060 3448-7350 82 µM -0.234656001832813 0.397152217563076 no 2026 0.407237869843603 677 570178
SGTC_1371 2421-0008 32.7 µM -0.235907391053979 0.396637285291029 no 2027 0.406752266436049 673 2827552
SGTC_2649 anisomycin 9.56 µM -0.238769389779718 0.395460284451161 no 2028 0.405642203597703 676 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2448 5185112 27.17 µM -0.240593103652653 0.39471077601135 no 2029 0.404935247846963 636 5718189
SGTC_770 0389-1121 67.2 µM -0.241329931392254 0.394408065476243 no 2030 0.40464970721088 640 6753108
SGTC_1217 1183-1422 255 µM -0.24186637982652 0.394187716757096 no 2031 0.404441850892603 641 2849664
SGTC_697 0508-1955 564 µM -0.242198383258596 0.39405136174376 no 2032 0.404313223868299 666 6243113
SGTC_1194 1488-0194 225 µM -0.244067963718914 0.393283761182427 no 2033 0.40358909179919 645 1391452
SGTC_1770 st043884 66.3 µM -0.244132907729321 0.393257104315094 no 2034 0.403563943394176 652 670149
SGTC_2553 4-methylesculetin 85.09 µM -0.244868854105832 0.392955063340409 no 2035 0.403278989223336 666 5319502
SGTC_438 sphingosine 6.67 µM -0.244960465074516 0.392917469636733 no 2036 0.403243521578026 649 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2339 9000433 200 µM -0.246002547282177 0.392489908583379 no 2037 0.402840130320768 636 2988954
SGTC_2234 tolnaftate 200 µM -0.247426078133045 0.391906050821054 no 2038 0.402289247020497 660 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_763 3453-1109 128 µM -0.247495599772168 0.391877542909257 no 2039 0.402262348236215 652 1560353
SGTC_2197 6588183 93.1375 µM -0.248173563099423 0.391599569004495 no 2040 0.402000060100051 649 884136
SGTC_88 0180-0332 8.668 µM -0.249461691854626 0.391071571795273 no 2041 0.401501834910358 645 3101745
SGTC_2617 dihydrotanshinone i 20.83 µM -0.249571901327162 0.391026406818398 no 2042 0.401459215277977 627 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2880 9042983 58.44 µM -0.249713768511485 0.390968270348828 no 2043 0.401404354866184 681 6464714
SGTC_777 1315-0167 517 µM -0.250303709473932 0.390726541610197 no 2044 0.401176244006685 645 4221767
SGTC_800 3448-7362 155 µM -0.250376110073578 0.390696878318786 no 2045 0.40114825138363 661 15991913
SGTC_1018 4259-0013 28.1 µM -0.250774151016231 0.390533808100437 no 2046 0.400994363796285 666 6801262
SGTC_82 0054-0107 293.755 µM -0.250811553873441 0.390518485811399 no 2047 0.400979904174841 654 3104697
SGTC_3113 9123498 49.47 µM -0.251713008106591 0.390149251539299 no 2048 0.400631450831734 654 8897275
SGTC_2129 girgensonine 121.053 µM -0.251765348977676 0.390127815839002 no 2049 0.400611221113976 680 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1962 st076595 64.5 µM -0.251847021077086 0.390094368483644 no 2050 0.400579655425209 665 279619
SGTC_2145 5634607 200 µM -0.252713837771694 0.38973942931691 no 2051 0.400244676955756 682 308662
SGTC_2915 7971052 15.16 µM -0.253498206217858 0.389418329813233 no 2052 0.399941623570057 654 5741558
SGTC_450 aminopyrene 156 nM -0.253726153118947 0.389325028583095 no 2053 0.399853563904026 658 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_3285 9112818 20.8695 µM -0.25610873252549 0.388350194849184 no 2054 0.398933439614374 667 17017947 YPR165W RHO1
SGTC_1181 1222-0449 220 µM -0.25653709739652 0.388175003487395 no 2055 0.398768069500527 666 658318
SGTC_601 0986-0029 62.9 µM -0.256765592901771 0.388081563393606 no 2056 0.398679866317796 646 24747981
SGTC_1665 st014639 11.4 µM -0.257597872571133 0.387741268886441 no 2057 0.398358635879011 657 981133 YIL048W NEO1
SGTC_2546 rhodinyl acetate 100 µM -0.257611505084172 0.387735695672491 no 2058 0.398353374785046 670 6708682
SGTC_3308 9128332 17.569 µM -0.258808758495955 0.387246327503728 no 2059 0.397891399883534 666 17332805 YDL196W YDL196W
SGTC_2384 9036245 200 µM -0.25895180248406 0.387187871333122 no 2060 0.397836214167171 642 6462766
SGTC_2278 7948257 134.34 µM -0.259782784078389 0.386848334109913 no 2061 0.397515665731803 649 1247028
SGTC_2999 9069765 71.4286 µM -0.260464633476415 0.386569796624134 no 2062 0.397252696223814 668 2097066
SGTC_64 000l-0018 272.079 µM -0.262682471920993 0.385664207891457 no 2063 0.396397663928042 669 6811119
SGTC_1311 1190-0148 100 µM -0.263161339878844 0.385468757918567 no 2064 0.39621311356606 657 1961333
SGTC_424 splitomicin 100 mM -0.266838079939105 0.383969068648307 no 2065 0.394796916684369 699 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_263 alizarin 107.927 µM -0.267278796737777 0.383789422686273 no 2066 0.394627255427279 676 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_3251 9135047 49.47 µM -0.267744230932592 0.383599728477008 no 2067 0.394448100494881 667 17682963
SGTC_1046 2001-0062 216 µM -0.268527298174409 0.383280641447692 no 2068 0.394146732642829 668 739778
SGTC_2238 6671620 73.2395 µM -0.268690765832753 0.383214041044604 no 2069 0.394083829179555 658 729941
SGTC_2357 9067248 200 µM -0.269139067954231 0.383031410388518 no 2070 0.393911333666271 688 9150235
SGTC_951 1171-0579 82.7 µM -0.269253881952517 0.382984641299401 no 2071 0.393867159439779 674 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2625 euphol 100 µM -0.269764767313476 0.38277655458836 no 2072 0.393670614905896 648 6708538 A triterpene alcohol.
SGTC_49 0717-0965 32.132 µM -0.270447693526324 0.382498447441841 no 2073 0.393407926232206 732 5889349 YGL099W LSG1
SGTC_443 clozapine 122 µM -0.270493034834685 0.382479985303619 no 2074 0.393390487340647 676 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_941 3237-0776 460 µM -0.270550312711502 0.38245666319838 no 2075 0.393368457786242 665 760008
SGTC_3114 9122766 49.47 µM -0.271506074262618 0.382067564199281 no 2076 0.393000914260468 655 17176985
SGTC_2028 5153890 36.43 µM -0.27240697164678 0.381700909902622 no 2077 0.392654556365021 688 2830968 YPR165W RHO1
SGTC_805 3852-0218 479 µM -0.274212203032524 0.380966522291802 no 2078 0.391960775378037 655 6615355
SGTC_3191 9110352 49.47 µM -0.274265192502106 0.38094497206552 no 2079 0.391940415804575 664 17122424
SGTC_3152 9099253 49.47 µM -0.274487231963544 0.380854675109435 no 2080 0.391855107190735 666 25236131
SGTC_632 0781-2353 4.65 µM -0.274899883776569 0.380686878922303 no 2081 0.391696578220439 670 6811515 YHR007C ERG11
SGTC_3120 9124077 49.47 µM -0.275710386117862 0.380357370530868 no 2082 0.391385258877131 672 18774327 YGL155W CDC43
SGTC_2796 7949634 45.45 µM -0.276265928612025 0.380131565766472 no 2083 0.391171911476342 657 2971588
SGTC_354 2783-3500 4.88 µM -0.276312948529393 0.380112456012712 no 2084 0.391153855714933 664 6740761
SGTC_1003 4049-0218 100 µM -0.276379374362659 0.380085459838862 no 2085 0.391128348434918 660 295161
SGTC_611 3453-1652 23.7 µM -0.277402391746903 0.379669768418472 no 2086 0.39073557265866 671 1560575
SGTC_1857 st056007 79.3 µM -0.277805132485432 0.379506157435938 no 2087 0.390580975530136 671 619834
SGTC_2299 7976368 114.88 µM -0.277975157491781 0.379437092282971 no 2088 0.39051571447092 675 2979718
SGTC_3010 9080089 71.4286 µM -0.281631346118071 0.377952861285539 no 2089 0.389113100988617 684 17027233
SGTC_1945 st075991 56.6 µM -0.281820477819123 0.377876131979887 no 2090 0.389040584038879 668 1084980
SGTC_107 0358-0022 2.6945 µM -0.282032765568748 0.37779001417865 no 2091 0.388959193192123 711 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1867 st057372 64 µM -0.282918736163398 0.377430672150662 no 2092 0.388619565863914 669 688837
SGTC_2739 tacrine 100.86 µM -0.283361381805543 0.377251178618817 no 2093 0.388449914274856 675 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_3275 9138069 49.47 µM -0.284666337447812 0.376722171417553 no 2094 0.387949891426588 665 17617007
SGTC_3273 9137859 49.47 µM -0.284763829851141 0.376682658904302 no 2095 0.387912542484481 659 2377234
SGTC_1795 st049545 62.3 µM -0.285842367178258 0.376245626814761 no 2096 0.387499428490769 642 5291882
SGTC_1842 st055362 61.2 µM -0.286157161767094 0.376118099370555 no 2097 0.387378876169807 651 676032
SGTC_355 1311-2252 105 µM -0.286870050262968 0.375829348846702 no 2098 0.387105911753074 661 5338538
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.287845191657769 0.375434487220933 no 2099 0.386732621337743 648 2724 A muscle relaxant with antifungal properties.
SGTC_3056 9094900 49.47 µM -0.288200926911839 0.375290472667997 no 2100 0.386596469651195 677 25236784
SGTC_1306 1185-0270 9.02 µM -0.289884957718846 0.374608952020675 no 2101 0.385952124883877 671 1548076
SGTC_262 fenpropimorph 62.5 µM -0.290382149920323 0.37440781505155 no 2102 0.385761948991652 683 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2354 9060492 162 µM -0.292489441622248 0.373555699218256 no 2103 0.384956215740057 698 6471895
SGTC_2408 sulbentine 18.36 µM -0.294322769876919 0.372814867088557 no 2104 0.384255637480062 652 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1956 st077085 54 µM -0.294440855771439 0.372767165685451 no 2105 0.384210525699612 679 24208685
SGTC_3027 9089541 49.47 µM -0.296732039073382 0.371842017428994 no 2106 0.38333554722811 683 9943819
SGTC_2435 5706476 10.6 µM -0.297643201596017 0.371474307779865 no 2107 0.382987749010892 659 5725375
SGTC_63 0099-0242 26.702 µM -0.300612841324078 0.370276692474455 no 2108 0.381854869096475 697 3898502 YLR359W ADE13
SGTC_122 0236-0016 402.397 µM -0.301266451037366 0.370013268866635 no 2109 0.381605660690065 675 6808838
SGTC_3252 9135871 49.47 µM -0.301846370786185 0.369779595486576 no 2110 0.381384589881833 692 17682838
SGTC_568 1193-0097 7.48 µM -0.302738199145107 0.369420335216924 no 2111 0.381044692139259 682 3646150
SGTC_1743 st037606 46.3785 µM -0.303191280470075 0.369237861547164 no 2112 0.380872046826109 662 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_734 2023-0417 80 µM -0.305073346628698 0.368480195243643 no 2113 0.380155145239742 702 3935732
SGTC_3055 9094636 49.47 µM -0.305449476435235 0.368328837263511 no 2114 0.380011922145992 671 25236176
SGTC_2252 omeprazole 400 µM -0.306111512626121 0.368062477654442 no 2115 0.379759871304711 669 4594 A proton pump inhibitor.
SGTC_1299 1079-1439 3.74 µM -0.306684892473006 0.367831838740777 no 2116 0.379541615032871 696 323161
SGTC_2282 7944268 200 µM -0.307575093238899 0.367473854777639 no 2117 0.379202837367593 722 2970414
SGTC_2187 6125751 200 µM -0.308092547149456 0.367265819553529 no 2118 0.379005956052503 684 874498
SGTC_1534 6-azauridine 81.6 µM -0.308485615930937 0.367107817691702 no 2119 0.378856421872554 675 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2965 9082772 38.63 µM -0.308976117469299 0.366910682348784 no 2120 0.378669847022561 663 16459634
SGTC_2787 5284540 71.43 µM -0.311273829782063 0.365987686750596 no 2121 0.377796230272297 705 736958
SGTC_1825 st052143 62.6 µM -0.311640162074018 0.365840601837649 no 2122 0.377657004127147 703 674173
SGTC_2094 5332512 191.667 µM -0.312261677442786 0.365591104294005 no 2123 0.377420830934447 714 755774
SGTC_3163 9099914 49.47 µM -0.313545443051484 0.36507593693805 no 2124 0.376933150664941 675 16268368
SGTC_3194 9111903 49.47 µM -0.31355724311439 0.365071202772005 no 2125 0.376928668935057 713 17087251
SGTC_1522 st012842 45.6 µM -0.313820483542354 0.364965596488573 no 2126 0.37682869306054 701 3491067 YOR116C RPO31
SGTC_110 0850-0284 111.64 µM -0.314429572622434 0.364721282593858 no 2127 0.376597399271622 656 3906265
SGTC_523 1934-0222 13.7 µM -0.316276813289509 0.363980665560054 no 2128 0.375896204431821 709 1361595
SGTC_2756 carbadox 75.1 µM -0.31652404483143 0.363881581107417 no 2129 0.375802388737116 672 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1406 3909-7906 11.9 µM -0.317158500575587 0.363627348171809 no 2130 0.375561668650721 679 X1406
SGTC_15 0266-0086 27.098 µM -0.31734382321324 0.363553098811661 no 2131 0.375491364164718 691 1712902 YIL048W NEO1
SGTC_1794 st048918 76.9 µM -0.317737293365264 0.363395472318392 no 2132 0.375342109997887 673 672303
SGTC_236 1509-0011 5.31 µM -0.317782899656757 0.36337720366076 no 2133 0.375324811469983 716 3107280
SGTC_1610 st001799 48.1 µM -0.318516477241735 0.363083394871416 no 2134 0.375046598972772 666 621897
SGTC_3036 9090181 49.47 µM -0.319586214146699 0.362655093674702 no 2135 0.374641013125894 671 25236586
SGTC_162 k030-0015 37.8 µM -0.319940802492431 0.362513161499132 no 2136 0.37450660315163 687 1809920 YMR134W ERG29
SGTC_1524 corynanthine 62.1 µM -0.321452989335714 0.361908086090824 no 2137 0.373933566170288 716 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_39 0986-0283 58.349 µM -0.322387695497408 0.361534252023158 no 2138 0.373579502309326 669 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2900 5328528 85.29 µM -0.32256466562934 0.361463488000273 no 2139 0.373512478561999 664 795359
SGTC_3049 9092223 49.47 µM -0.323137848561194 0.36123432519763 no 2140 0.373295423751196 709 8623917
SGTC_537 1334-0398 209 µM -0.324580667105378 0.360657696159047 no 2141 0.372749230539036 699 5846986
SGTC_917 harmaline 728.087 nM -0.324793709342401 0.360572579654277 no 2142 0.372668602939095 680 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1322 1348-1070 12 µM -0.325365277603483 0.360344255821882 no 2143 0.372452315765047 670 6758089
SGTC_841 0251-0215 91.2 µM -0.325897183469959 0.360131820618372 no 2144 0.37225107336777 710 3888614
SGTC_1846 st056244 14.8 µM -0.326234456531348 0.359997141198292 no 2145 0.372123486828145 699 5393182
SGTC_984 1492-0255 2.91 µM -0.326565653688373 0.359864904910753 no 2146 0.371998212394074 711 1585198
SGTC_1418 3966-3099 2.4 µM -0.326856516153092 0.35974878678981 no 2147 0.3718882056226 695 740335
SGTC_607 4491-0986 66.8 µM -0.327207618313803 0.359608637020773 no 2148 0.371755429594031 698 698981 YDR232W HEM1
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.32739183264935 0.359535111567036 no 2149 0.371685771503231 715 229346 A bile salt which induces apoptosis.
SGTC_1091 telmisartan 47.6 µM -0.327961779916636 0.359307661498775 no 2150 0.37147028048002 707 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1179 1021-1431 9.29 µM -0.328802585990471 0.358972210260048 no 2151 0.371152454164841 729 2840958
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.329525514825617 0.358683874693638 no 2152 0.370879255907577 693 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1390 3413-2614 145 µM -0.329994087326933 0.358497030531537 no 2153 0.370702214873411 719 3421432
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.330817222625566 0.358168885819267 no 2154 0.370391275461164 687 688788
SGTC_652 0437-0092 114 µM -0.331447274292575 0.35791778507716 no 2155 0.370153330594008 681 3091274
SGTC_3332 9141069 11.198 µM -0.331597104133805 0.357858080945868 no 2156 0.370096753271451 680 17332883
SGTC_1709 st033179 39.1045 µM -0.331850550672665 0.357757095593008 no 2157 0.37000105559446 685 573381
SGTC_3132 9126706 49.47 µM -0.331868491838189 0.357749947342608 no 2158 0.369994281579802 738 850858
SGTC_1253 0550-0034 176 µM -0.332134183054094 0.357644094546118 no 2159 0.369893969731948 675 5969915
SGTC_521 r062-0005 13.8 µM -0.332991429049886 0.357302637859682 no 2160 0.369570376474169 677 2832033
SGTC_2543 pimpinellin 60.67 µM -0.333191897555025 0.357222804074201 no 2161 0.369494716930335 693 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_548 1436-0017 110 µM -0.33541261498022 0.356338853124541 no 2162 0.368656926595431 704 9677137
SGTC_3083 9117465 49.47 µM -0.335677360896635 0.356233523049612 no 2163 0.368557089800226 740 16420915
SGTC_613 3914-0030 117 µM -0.335955283337084 0.356122962449914 no 2164 0.368452293628026 672 1145395
SGTC_849 0386-0493 241 µM -0.337696652994389 0.355430502127173 no 2165 0.367795898635628 693 726119
SGTC_1570 verbenone 133 µM -0.338028519402687 0.355298588600908 no 2166 0.367670848042249 719 29025 A natural terpanoid with antifungal properties.
SGTC_3213 9129884 49.47 µM -0.338467146046334 0.355124265566141 no 2167 0.367505590644839 711 17190742
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.340547340124155 0.354297949084906 no 2168 0.366722189252753 686 6857784
SGTC_935 2996-0153 430 µM -0.341258208647125 0.354015727393857 no 2169 0.366454603097115 679 23738523
SGTC_3102 9121669 49.47 µM -0.34187022561308 0.353772814952759 no 2170 0.366224278777706 678 41905072
SGTC_2588 indole-3-carbinol 100 µM -0.342595906954812 0.353484865714284 no 2171 0.365951240852193 713 3712 Induces cell cycle arrest.
SGTC_3241 9133421 49.47 µM -0.342812267158971 0.353399030534243 no 2172 0.365869848358796 700 17018221
SGTC_400 oxethazaine 37.5 µM -0.342870051659893 0.353376107325438 no 2173 0.365848111442521 709 4621 A local anesthetic.
SGTC_2222 6885208 172.143 µM -0.343219244726647 0.353237593169229 no 2174 0.365716763925017 674 609514
SGTC_250 brefeldin a 552.239 µM -0.343527580132073 0.353115302151715 no 2175 0.36560079793226 685 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2512 diallyl trisulfide 49.23 µM -0.343651597964304 0.353066118866353 no 2176 0.365554157867667 711 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_886 0866-0150 153 µM -0.344917364378788 0.352564278729237 no 2177 0.365078247951335 693 271463
SGTC_687 k029-0044 34.9 µM -0.345400614575572 0.352372751473725 no 2178 0.364896607603806 716 5829338
SGTC_1751 st044839 27.194 µM -0.346116201627541 0.352089210571671 no 2179 0.36462769396919 687 5291326
SGTC_1615 st002656 86.5 µM -0.34644100969007 0.351960537246096 no 2180 0.364505654872557 670 1584458
SGTC_918 glabranin 770.725 nM -0.349983947820391 0.350558099323942 no 2181 0.363175372266746 708 124049 Also referred to as licorice root.
SGTC_638 3970-0837 4.09 µM -0.350221813204496 0.350464015274229 no 2182 0.363086118792065 682 4118451 YLR208W SEC13
SGTC_1907 st060210 83.7 µM -0.35049887765242 0.350354438194186 no 2183 0.362982166150977 706 688793
SGTC_2794 7785382 27.27 µM -0.351317876709207 0.350030602558235 no 2184 0.362674942486875 736 2205081
SGTC_661 1304-0007 33.6 µM -0.351762076913734 0.349855009538965 no 2185 0.362508350662718 686 3117130
SGTC_1700 st030840 7.9285 µM -0.352809876086091 0.349440940176134 no 2186 0.362115489631503 687 5499307
SGTC_2707 st078556 66.6 µM -0.352844071871628 0.349427429698095 no 2187 0.362102670734167 700 17250899
SGTC_1863 st057641 20.1 µM -0.353414334927821 0.34920215150881 no 2188 0.361888920309567 702 3921635
SGTC_991 3996-0057 64.7 µM -0.354412123117349 0.348808110518203 no 2189 0.361515025252293 691 715343
SGTC_1497 4476-2978 41.3 µM -0.35528820736748 0.348462266558224 no 2190 0.361186844549045 691 1528379
SGTC_227 fluconazole 33.516 µM -0.355546925390657 0.348360158826312 no 2191 0.361089948436864 708 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2483 5729050 27.16 µM -0.357392377034217 0.347632137195735 no 2192 0.360399041347443 727 2865180
SGTC_764 1951-2361 146 µM -0.357548202602883 0.34757069044606 no 2193 0.360340723615683 711 5438930
SGTC_3280 9140961 49.47 µM -0.357603373571459 0.347548935819065 no 2194 0.360320076654964 707 4901226
SGTC_3270 9137563 49.47 µM -0.357805838309834 0.347469105654706 no 2195 0.360244310558783 674 17015724
SGTC_781 4335-2806 94.4 µM -0.358343918160536 0.347256978127087 no 2196 0.360042977686839 736 845254
SGTC_2364 9055074 200 µM -0.358545389606172 0.347177564230012 no 2197 0.359967603275691 722 6470630
SGTC_1285 0929-0069 65.5 µM -0.358624360864253 0.347146437999787 no 2198 0.359938060067544 691 1206237
SGTC_2158 5657123 3.6195 µM -0.359102523110435 0.346957994142807 no 2199 0.359759197080801 751 2858827
SGTC_3159 9100096 49.47 µM -0.36188230135867 0.345863233670512 no 2200 0.358719993164717 668 25236875
SGTC_986 1493-0483 84 µM -0.361916247478961 0.345849872603441 no 2201 0.35870730904881 726 40079
SGTC_54 0159-0055 9 µM -0.364887848484056 0.344681007016047 no 2202 0.357597562683225 759 3319099
SGTC_2523 spermine 47.74 µM -0.365192370948712 0.344561307992952 no 2203 0.35748390636044 700 1103 A DNA binding polyamine.
SGTC_3243 9134147 49.47 µM -0.365413780392864 0.344474288078232 no 2204 0.357401278082296 721 24282180
SGTC_3214 9129694 49.47 µM -0.365972067000748 0.344254902856566 no 2205 0.357192959560525 732 17158655
SGTC_17 0960-0276 49.807 µM -0.366300975199007 0.34412567907482 no 2206 0.35707025099401 704 6821114
SGTC_2068 5226020 147 µM -0.366928860756551 0.343879041496437 no 2207 0.356836041469131 730 1810509
SGTC_2912 7964298 10.93 µM -0.369536813333124 0.342855332459232 no 2208 0.355863819394952 699 2975850
SGTC_1102 cgs 12066b 26.1 µM -0.369544768054585 0.342852211723323 no 2209 0.355860855373586 686 6438352 A 5-HT1B full agonist.
SGTC_679 0422-0091 41.4 µM -0.369715793959704 0.342785118732895 no 2210 0.35579713124788 721 627384 YHR062C RPP1
SGTC_2777 climbazole 1.536 µM -0.369961786195748 0.342688625352886 no 2211 0.355705481788646 710 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2670 beta-carotene 100 µM -0.37069599616535 0.342400683812907 no 2212 0.355431986402124 691 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_669 0108-0021 26.2 µM -0.371478551181589 0.342093883196246 no 2213 0.35514056428492 790 17201
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.371686114921355 0.342012525331419 no 2214 0.355063282118552 726 165506
SGTC_2629 bisabolol 100 µM -0.375314203359467 0.340591626683204 no 2215 0.353713402092499 737 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2507 purpurin 79.67 µM -0.375347917324805 0.340578433565383 no 2216 0.353700866939747 685 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2443 5493264 126.67 µM -0.376432256537662 0.340154208615536 no 2217 0.353297784620972 726 5340055
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.376535249623635 0.340113925243029 no 2218 0.353259507463112 715 5282362
SGTC_1852 st056254 31.4 µM -0.376713624374949 0.340044162386687 no 2219 0.353193218384023 709 442583
SGTC_1638 st008370 60.6 µM -0.377155027382948 0.339871552002203 no 2220 0.353029199752979 687 24207134
SGTC_1897 st060201 15 µM -0.377537307890592 0.33972208855845 no 2221 0.352887172203558 704 611878
SGTC_1084 voriconazole 435 nM -0.37764295145136 0.339680788644734 no 2222 0.352847926377077 728 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3341 9147222 25.867 µM -0.37857574899242 0.33931620770393 no 2223 0.352501466757137 729 1939759
SGTC_1171 0368-0077 21.4 µM -0.380176373529468 0.338690959240563 no 2224 0.351907248050135 690 3239779
SGTC_2776 terbinafine 19.92 µM -0.380242955333501 0.338664960149275 no 2225 0.351882537924616 672 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_620 0109-0052 432 µM -0.381576310871555 0.338144468898827 no 2226 0.351387829111074 713 493037
SGTC_1051 3253-3903 78 µM -0.382291006556424 0.337865606127201 no 2227 0.351122762375851 702 5509239
SGTC_2374 9071832 200 µM -0.382369762934799 0.337834882093303 no 2228 0.351093557593509 731 17381698
SGTC_2658 polymyxin b sulfate 77.05 µM -0.383093898519394 0.337552436699763 no 2229 0.350825071728732 706 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_825 1988-2224 89.6 µM -0.383181975864671 0.337518088817717 no 2230 0.350792420598258 710 1180859
SGTC_2969 9091408 28.7 µM -0.38359361798994 0.337357577008254 no 2231 0.350639835463156 704 4286311
SGTC_1298 1079-1278 263 µM -0.383848093368367 0.337258364103492 no 2232 0.35054552004255 744 2840950
SGTC_2174 5790901 200 µM -0.38441443719618 0.337037602948248 no 2233 0.350335650858331 711 786020
SGTC_2283 7944793 200 µM -0.384705344813494 0.336924228798705 no 2234 0.35022786741504 683 2970533
SGTC_2807 7945238 51.95 µM -0.385273883475377 0.336702697495845 no 2235 0.350017254426551 740 17148797
SGTC_346 4513-0042 7.16 µM -0.38541337891114 0.33664835169934 no 2236 0.349965585917264 707 2827372
SGTC_723 4182-0001 115 µM -0.386055786971371 0.336398121048303 no 2237 0.349727676600865 714 744821 YLR208W SEC13
SGTC_1729 st035615 45.989 µM -0.387071815565556 0.336002505742074 no 2238 0.349351521178397 688 17385451
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.387289644188177 0.335917712526729 no 2239 0.349270895626108 694 688664
SGTC_2815 7968870 71.43 µM -0.388004230318004 0.335639607294746 no 2240 0.34900645151986 734 2977326 YHR190W ERG9
SGTC_905 2-aminofluorene 215 µM -0.389532288323421 0.335045214285135 no 2241 0.348441215185185 691 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1292 0kpi-0043 232 µM -0.389821682307603 0.334932690564946 no 2242 0.348334204743647 737 3333905
SGTC_1723 st034307 2.5525 µM -0.389867495226938 0.334914878698258 no 2243 0.348317265412616 688 867466
SGTC_3317 9138495 8.753 µM -0.390403852986253 0.334706372732714 no 2244 0.348118969596935 724 17020139
SGTC_1838 st055369 84.5 µM -0.391114307394551 0.334430266163109 no 2245 0.347856372765254 673 676036
SGTC_117 lucigenin 22.078 µM -0.391609592874796 0.334237834460387 no 2246 0.347673349423693 746 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1677 st019204 53.9 µM -0.392142844756898 0.334030700485829 no 2247 0.347476336001738 712 3945625
SGTC_660 4031-1742 102 µM -0.392320707287509 0.33396162359886 no 2248 0.347410632676635 693 6738706
SGTC_3289 9119912 71.43 µM -0.393104336919325 0.333657350541885 no 2249 0.347121210516781 761 17014829
SGTC_84 0443-0269 128.823 µM -0.393741988521209 0.33340983952596 no 2250 0.346885768983661 735 6150058
SGTC_2291 7917025 104.35 µM -0.395173627193634 0.332854398565804 no 2251 0.34635737726209 706 2964612
SGTC_527 4476-4215 268 µM -0.39523170427394 0.332831873801714 no 2252 0.346335948372505 689 4418754
SGTC_343 4130-2827 29.8 µM -0.395713987305796 0.332644847224436 no 2253 0.346158017838189 695 1118244
SGTC_2711 st079103 59.1 µM -0.39743228993737 0.331978838153015 no 2254 0.345524354072054 719 54693780
SGTC_2788 5282734 71.43 µM -0.397877031595117 0.331806543928177 no 2255 0.345360415726657 755 743706
SGTC_146 3448-8650 53.125 µM -0.400483808336543 0.330797387158926 no 2256 0.344400103471771 747 2891488 YIL048W NEO1
SGTC_3178 9107506 49.47 µM -0.401353690077105 0.330460904410986 no 2257 0.344079869852189 718 8897194
SGTC_1457 k015-0032 57.3 µM -0.401960568128475 0.330226236383946 no 2258 0.343856523191585 738 4302660
SGTC_3349 9149703 23.001 µM -0.40235963122349 0.330071962767742 no 2259 0.343709687440048 724 4910494
SGTC_234 nsc-17383 10.7 µM -0.402638495463065 0.329964173917675 no 2260 0.343607092995664 720 408974
SGTC_931 2812-0076 566 µM -0.40386706795624 0.329489464372861 no 2261 0.343155237146641 715 3450959
SGTC_1430 4049-0248 69.1 µM -0.404088176151217 0.329404059263097 no 2262 0.34307393969611 738 22774488
SGTC_2395 5646831 180.19 µM -0.404123481509481 0.329390423061843 no 2263 0.343060959232201 763 6808628
SGTC_1661 st013063 9.66 µM -0.404406640039698 0.329281065245532 no 2264 0.34295685909823 735 721395
SGTC_2985 9022375 71.43 µM -0.405976989495738 0.328674850529028 no 2265 0.342379753862258 750 4939335
SGTC_1041 0206-0046 107 µM -0.406591017833943 0.328437934641944 no 2266 0.342154197699129 735 50494
SGTC_719 2810-4230 27.3 µM -0.40695407121855 0.328297887037851 no 2267 0.342020860746978 712 721079
SGTC_1641 st009299 47.1 µM -0.408197249488104 0.327818514689357 no 2268 0.341564433665376 706 4046054
SGTC_1960 st011366 51.8 µM -0.408902997940773 0.327546502629223 no 2269 0.341305424429095 706 3972846
SGTC_2118 5526350 200 µM -0.408935349291893 0.327534035849841 no 2270 0.341293553294284 736 743594
SGTC_958 1222-0007 33 µM -0.409120001654583 0.327462882680446 no 2271 0.341225799220834 740 7312461
SGTC_1837 st055472 66.5 µM -0.40934098472237 0.327377738226998 no 2272 0.341144721132072 717 676091
SGTC_2365 9042475 200 µM -0.410412936353069 0.326964844320808 no 2273 0.340751529115015 709 6464479
SGTC_21 0849-0113 22.993 µM -0.412477082191874 0.326170374184074 no 2274 0.339994887582789 725 1560156
SGTC_2883 9059145 45.46 µM -0.4125197644838 0.32615395448142 no 2275 0.339979248577739 730 16476510
SGTC_1169 aniline yellow 25.8 µM -0.414470356367671 0.325403929841795 no 2276 0.339264836176363 725 6051 A DNA damaging agent.
SGTC_3059 1327-0034 3 µM -0.415251655535285 0.325103709480359 no 2277 0.338978843915016 711 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1387 3342-1166 1.8 µM -0.415313356565615 0.325080005206904 no 2278 0.338956262384993 717 3418228
SGTC_2635 hydroquinidine 100 µM -0.415861179934587 0.324869573734062 no 2279 0.33875579371337 727 442912 An experimental heart treatment.
SGTC_610 4215-0184 155 µM -0.416412823452803 0.324657731307185 no 2280 0.338553973253117 731 5605015
SGTC_3133 9127736 49.47 µM -0.416670698765502 0.32455872134401 no 2281 0.338459644681596 725 27243420
SGTC_92 0063-0024 660.874 µM -0.41930759334385 0.323547011182582 no 2282 0.337495673911892 734 3594437
SGTC_2879 9041815 71.43 µM -0.419403861297572 0.323510100197311 no 2283 0.337460501312911 720 4942971
SGTC_888 0916-0002 6.97 µM -0.419548316032028 0.323454716731418 no 2284 0.337407725786215 719 2802138 YIL048W NEO1
SGTC_1056 3448-1962 115 µM -0.419741406475536 0.323380692604279 no 2285 0.337337186538572 721 715507
SGTC_1369 1866-0067 208 µM -0.420067379195579 0.323255741920393 no 2286 0.337218116091446 729 3531355
SGTC_3067 9117431 49.47 µM -0.420322917603554 0.323157803800847 no 2287 0.337124785101517 736 17150885
SGTC_878 0828-0289 13.7 µM -0.421509541016975 0.322703177027189 no 2288 0.336691522823461 711 745350 YLR208W SEC13
SGTC_1619 st003326 88.7 µM -0.42176338757764 0.32260595607628 no 2289 0.336598865980963 689 2849032
SGTC_1805 st050013 60.3 µM -0.423680382690557 0.321872156158482 no 2290 0.335899461914622 738 4037144
SGTC_2087 5276107 200 µM -0.425028766302279 0.32135642867813 no 2291 0.335407852350963 723 144405
SGTC_328 k915-0120 63.5 µM -0.427642133882169 0.320357853041571 no 2292 0.334455842668793 722 6624543
SGTC_2837 9008476 45.46 µM -0.428291074611322 0.320110091929997 no 2293 0.334219608127299 764 2992805
SGTC_1321 1326-2144 215 µM -0.429266348338743 0.319737889972411 no 2294 0.333864701752969 747 3513030
SGTC_813 k007-0158 173 µM -0.429586997046311 0.319615557712876 no 2295 0.333748048721645 729 6523916
SGTC_1985 st071382 65.5 µM -0.42976777586218 0.319546596551025 no 2296 0.333682287889188 753 6123237
SGTC_760 0568-0725 82.9 µM -0.429827763535154 0.319523714608966 no 2297 0.333660467659737 747 3916171
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.430050438451976 0.319438782592493 no 2298 0.333579475643438 735 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.431365115880142 0.318937535330618 no 2299 0.333101455235396 721 442882
SGTC_2845 9003024 42.97 µM -0.431677061264806 0.318818648414617 no 2300 0.332988070773466 715 2990173
SGTC_2928 9011484 9.79 µM -0.43329593937708 0.318201970091681 no 2301 0.332399893871359 740 2994751
SGTC_276 colchicine 750 µM -0.434957197506431 0.317569671424923 no 2302 0.331796748083574 770 2833 A microtubule depolymerizer.
SGTC_630 4356-0227 183 µM -0.436256220047633 0.317075615205224 no 2303 0.331325421057144 754 779312
SGTC_1670 st016595 4.04 µM -0.43666203270754 0.316921339563173 no 2304 0.331178233922634 747 597879
SGTC_3031 9088762 49.47 µM -0.439351045806507 0.31589987691181 no 2305 0.33020359615005 740 205253
SGTC_1781 st038725 66.3 µM -0.43950580858056 0.315841130571768 no 2306 0.330147537063626 711 4270275 YIL048W NEO1
SGTC_731 3966-0296 387 µM -0.440116718042 0.315609281121933 no 2307 0.329926287071604 719 660956
SGTC_53 0973-0023 39.979 µM -0.440417097735773 0.315495309053106 no 2308 0.329817521884801 754 674768
SGTC_1150 3909-7983 10.9 µM -0.440496937793548 0.315465018557188 no 2309 0.329788614831333 732 23965914
SGTC_704 1310-0270 142 µM -0.443131057824135 0.314466356875827 no 2310 0.328835470939293 769 5718033
SGTC_698 k064-0052 127 µM -0.446004689786001 0.313378436684535 no 2311 0.327796929137963 751 5088751
SGTC_2709 st078560 56 µM -0.446290171896822 0.313270445232656 no 2312 0.327693827315548 763 17250903
SGTC_828 2074-0507 139 µM -0.446363370752018 0.313242758333081 no 2313 0.327667393675197 731 X828
SGTC_1190 1486-1332 13 µM -0.446891755165147 0.313042932257719 no 2314 0.327476608617602 751 4150046
SGTC_606 k015-0008 38.6 µM -0.447181192629521 0.312933495159345 no 2315 0.327372119814255 762 1970475
SGTC_937 3122-0005 46.7 µM -0.447717040858187 0.31273093298273 no 2316 0.327178710824104 758 759535
SGTC_268 camptothecin 39.6153 µM -0.449441180680215 0.312079554868095 no 2317 0.32655671504311 756 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_368 fentichlor 4.58 µM -0.449892264598258 0.311909232678009 no 2318 0.326394062746536 776 7329 A pesticide.
SGTC_2185 6113692 200 µM -0.452082143627436 0.311082940825332 no 2319 0.325604903477832 745 874150
SGTC_94 0334-0113 514.748 µM -0.452226386141865 0.311028548149292 no 2320 0.325552950671421 735 6795178
SGTC_1800 st050079 29.0735 µM -0.452488368714943 0.310929767214263 no 2321 0.325458599295709 745 3645560
SGTC_1400 3771-8998 51.5 µM -0.452839645564318 0.310797339112562 no 2322 0.325332106700791 723 670767
SGTC_2524 avocatin b 10.57 µM -0.452973975957063 0.310746704281368 no 2323 0.325283740484505 745 6710748
SGTC_1353 1498-1206 8.11 µM -0.453609625761732 0.310507149489499 no 2324 0.325054912053046 743 6756808
SGTC_2875 9039966 71.43 µM -0.454313014116699 0.31024215998225 no 2325 0.324801775222435 741 6463691
SGTC_1012 4112-3522 18 µM -0.456452820753007 0.309436630510412 no 2326 0.324032194952766 728 3112398
SGTC_2505 galangin 7.89 µM -0.457122377609354 0.309184763783699 no 2327 0.323791543391905 753 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1574 spiramycin 23.7 µM -0.457966448885185 0.308867377844695 no 2328 0.323488272954737 734 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_9 0092-0002 10.449 µM -0.458264160728685 0.308755466874865 no 2329 0.323381334583563 741 759368
SGTC_256 clotrimazole 625 nM -0.458747045047308 0.308573986655808 no 2330 0.323207913111872 718 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_879 0831-1030 162 µM -0.46054366364734 0.307899182484669 no 2331 0.322563019051076 754 1549252
SGTC_3 0833-0587 95.581 µM -0.461461841409582 0.307554568347844 no 2332 0.32223364610519 733 5382644
SGTC_3004 9076122 71.4286 µM -0.461660740180041 0.307479939229798 no 2333 0.32216231460291 764 44782551
SGTC_1019 4262-0212 3.4 µM -0.46177704381602 0.307436304452907 no 2334 0.322120607409342 752 4677213
SGTC_1981 st071826 47 µM -0.462480863587171 0.307172303641395 no 2335 0.321868261151829 720 11838600
SGTC_2695 st077686 51.995 µM -0.462540931566749 0.307149776937255 no 2336 0.321846728290217 731 2876092
SGTC_1451 4152-0210 104 µM -0.463390981432114 0.306831069145423 no 2337 0.321542070935601 776 659563
SGTC_264 promethazine 12.5 mM -0.464255870968864 0.306506947329488 no 2338 0.321232218195531 772 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_809 3998-0021 90 µM -0.465460792615181 0.306055648973099 no 2339 0.320800753967754 767 715485
SGTC_933 2914-0560 114 µM -0.466247075581461 0.305761308572196 no 2340 0.320519328332842 727 463887
SGTC_989 1501-0895 10.3 µM -0.469051911637792 0.3047123575338 no 2341 0.319516265374967 769 2830112
SGTC_226 1,3-diallylurea 8.28947 mM -0.469734925179931 0.304457166952252 no 2342 0.319272206119074 748 74537 YKL182W FAS1
SGTC_3334 9142812 21.919 µM -0.471698980550602 0.30372387837562 no 2343 0.318570832448828 730 45283678
SGTC_657 3534-0529 86.7 µM -0.47251543774286 0.303419282646364 no 2344 0.318279462628823 755 1049549
SGTC_2335 9018011 154.17 µM -0.47270382794003 0.303349019288623 no 2345 0.318212247600257 730 6458208
SGTC_834 0312-0008 75.7 µM -0.473093143230373 0.303203840514068 no 2346 0.318073364232029 761 6385573 YIL048W NEO1
SGTC_780 0109-0199 192 µM -0.473571668854202 0.303025437070419 no 2347 0.317902691233598 772 610414
SGTC_2679 rapamycin 1 nM -0.474177238476167 0.302799736565339 no 2348 0.317686761619264 755 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1429 4049-0205 9.46 µM -0.475266159665132 0.302394076691603 no 2349 0.31729863802417 737 22774478
SGTC_2476 5806916 10.51 µM -0.475410566659891 0.302340298524783 no 2350 0.317247182189947 732 2870194
SGTC_1392 3455-1037 33.9 µM -0.478220739002859 0.301294626163173 no 2351 0.316246551548527 752 981132
SGTC_2903 5923464 63.88 µM -0.478642444868625 0.301137848961328 no 2352 0.316096508665893 762 2876576
SGTC_471 1-acyl-paf 4 µM -0.479011038131084 0.301000847495953 no 2353 0.31596538804043 730 16759367
SGTC_3019 9081971 49.47 µM -0.479191323726563 0.300933847848973 no 2354 0.315901263013079 746 16451803
SGTC_3129 9127257 49.47 µM -0.47924604755046 0.300913512131061 no 2355 0.315881799621535 779 837894
SGTC_3073 9114972 49.47 µM -0.479425120295472 0.300846971902429 no 2356 0.315818113142197 746 41905075
SGTC_1294 1000-1494 117 µM -0.47948361727456 0.300825236909678 no 2357 0.31579731011875 720 712797 YDL207W GLE1
SGTC_1927 st060202 13.8 µM -0.4796337258981 0.300769466162379 no 2358 0.315743930318855 717 688887
SGTC_691 1548-0686 185 µM -0.480874131995908 0.300308789391817 no 2359 0.31530297938747 770 46495133
SGTC_1949 st076024 69.1 µM -0.481296427417626 0.300152025093039 no 2360 0.315152917910217 764 2921930
SGTC_1278 0874-0585 172 µM -0.481686629095302 0.300007207521409 no 2361 0.315014287961484 732 766306
SGTC_2432 5630864 12.22 µM -0.482226548281607 0.299806876668313 no 2362 0.314822509692785 770 5714970
SGTC_629 3448-6466 76.7 µM -0.482527281896173 0.299695319163395 no 2363 0.314715711330578 774 573744
SGTC_170 4197-0004 226 µM -0.482890012836092 0.299560788697197 no 2364 0.314586916717283 754 218692
SGTC_1225 1216-0074 20.6 µM -0.483729106109306 0.299249688830069 no 2365 0.314289066941483 753 4241466
SGTC_2236 dapsone 200 µM -0.485631835961873 0.298544781714536 no 2366 0.313614110153927 750 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_3319 9138450 16.7555 µM -0.486739192682887 0.298134885660297 no 2367 0.313221583527633 759 2029690
SGTC_2178 5812956 200 µM -0.487245975145614 0.297947382039094 no 2368 0.313042014010657 745 5403383
SGTC_3260 9137109 49.47 µM -0.487875884240306 0.297714397960179 no 2369 0.312818878526567 761 17478346
SGTC_327 1273-0057 3.96 µM -0.48879295987457 0.29737534845697 no 2370 0.312494141360549 769 3108138
SGTC_2014 4013930 200 µM -0.48925741908998 0.297203701834254 no 2371 0.31232973151096 777 64556
SGTC_2964 9083345 53.42 µM -0.49260362488188 0.295968410949813 no 2372 0.311146343135142 747 17741579
SGTC_1765 st044815 90.4 µM -0.493619551575704 0.295593836776975 no 2373 0.310787445076549 752 645695
SGTC_3283 9109332 35.8195 µM -0.494209015892086 0.295376600081725 no 2374 0.310579286540453 744 17027281
SGTC_2433 5607874 27.82 µM -0.494536983183195 0.295255765322503 no 2375 0.310463497141676 753 2252428
SGTC_164 4100-3994 89.624 µM -0.495725273564395 0.294818147763573 no 2376 0.310044126588625 788 4615967
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.4974420672394 0.294186424310041 no 2377 0.309438673314398 758 23665772 A membrane-active detergent.
SGTC_55 0767-0285 6.563 µM -0.498600480424263 0.293760520151247 no 2378 0.309030433315652 777 3116166
SGTC_2106 5357045 167.29 µM -0.499053762248044 0.293593943484501 no 2379 0.308870754998845 752 668842
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.499355651276664 0.293483026467461 no 2380 0.308764428101127 748 641818 YHR062C RPP1
SGTC_2990 9074105 71.4286 µM -0.500043136821387 0.293230509927424 no 2381 0.308522351910653 774 6502001
SGTC_1747 st037496 66.6 µM -0.500189627314957 0.293176716329122 no 2382 0.30847078068862 765 723305
SGTC_2682 pyrogallin 40.03 µM -0.500246305929769 0.293155904283873 no 2383 0.308450828288649 757 822798 An ATP competetive kinase inhibitor.
SGTC_2504 purpurogallin 52.29 µM -0.500889558549465 0.292919753827239 no 2384 0.308224425684151 723 5281571 An antioxidant.
SGTC_473 2-arachidonoylglycerol 10 µM -0.501005250085103 0.292877290599522 no 2385 0.308183714013924 747 5282280 An endocannabinoid.
SGTC_2325 6158266 200 µM -0.502785603142871 0.292224193397 no 2386 0.307557508365479 734 3623240
SGTC_2661 dactinomycin 12.96 µM -0.503900527632416 0.291815544513953 no 2387 0.307165639888098 750 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1165 k072-0275 30.3 µM -0.504880956470447 0.291456411940753 no 2388 0.306821225175076 743 6153523 YGL055W OLE1
SGTC_3234 9132280 49.47 µM -0.505669531132311 0.291167705529885 no 2389 0.306544330554715 752 17612295
SGTC_221 trifluoperazine 10.304 µM -0.507261878687438 0.290585135887087 no 2390 0.305985541360775 781 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_285 1486-1325 46 µM -0.507338531825649 0.290557105653006 no 2391 0.305958653490546 754 22310230
SGTC_766 1391-0721 126 µM -0.50758011425142 0.290468772969549 no 2392 0.305873919679736 780 1020919 YIL115C NUP159
SGTC_89 0302-0250 142.109 µM -0.508542892582254 0.290116865693043 no 2393 0.305536333308696 776 4203518 YLR208W SEC13
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.509541339214735 0.289752132394576 no 2394 0.305186414832611 767 688803
SGTC_177 1327-0068 8.361 µM -0.509893004004772 0.289623720240964 no 2395 0.305063211748235 760 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1510 1123-0200 71.5 µM -0.510007032258 0.289582087991499 no 2396 0.305023267559071 800 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_139 0099-0334 718.624 µM -0.510441799115373 0.289423378360223 no 2397 0.304870989694079 763 97690
SGTC_440 fluspirilene 35.1 µM -0.510915130252578 0.289250637489643 no 2398 0.304705243041219 771 3396 An atypical antipsychotic.
SGTC_547 1120-0019 610 nM -0.511227482278299 0.289136672041893 no 2399 0.304595888490419 757 3676939
SGTC_363 0455-0021 3.06 µM -0.511456608574678 0.289053085944207 no 2400 0.304515682397338 762 4597466
SGTC_2396 5342950 42.78 µM -0.512473000084233 0.288682439763841 no 2401 0.304160005988854 768 1886677
SGTC_1646 st011709 75.6 µM -0.512774839277691 0.288572411576018 no 2402 0.304054415930121 771 5757843
SGTC_3286 9117135 37.221 µM -0.51288301399055 0.288532983906883 no 2403 0.304016577988563 766 3438150
SGTC_1007 4101-0031 70 µM -0.513097696877617 0.288454743509342 no 2404 0.30394149125383 776 1146276
SGTC_885 0865-0106 16.8 µM -0.513241856010855 0.288402210849887 no 2405 0.303891075301586 767 2793380
SGTC_1205 4161-2785 76 µM -0.513783646543313 0.288204818690483 no 2406 0.303701631344429 774 3498106
SGTC_655 k060-0012 42 µM -0.514224621440084 0.288044204052637 no 2407 0.303547477778586 762 5994525
SGTC_292 k038-0015 474 µM -0.514229934440657 0.288042269175897 no 2408 0.303545620702275 779 46368540
SGTC_1121 fusaric acid 630.51 nM -0.514608879848014 0.287904281504538 no 2409 0.303413179346441 735 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1954 st077032 68.9 µM -0.516209293878127 0.287321857678805 no 2410 0.302854119924137 796 698907
SGTC_758 0868-0029 16 µM -0.517157576161706 0.286977021330363 no 2411 0.302523082054458 731 762687
SGTC_1914 st062367 72.6 µM -0.517867776785116 0.286718890206411 no 2412 0.302275262899928 761 978205
SGTC_580 1123-0028 41 µM -0.518143176029382 0.286618822602964 no 2413 0.302179188924716 771 1677248 YPR107C YTH1
SGTC_1140 3229-1848 2.98 µM -0.519869900325381 0.285991787058004 no 2414 0.301577127843015 774 2849525
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.521281474937215 0.285479678498219 no 2415 0.301085352009734 756 2333 A French combination drug.
SGTC_1843 st055809 45.5 µM -0.522022549624455 0.28521099710608 no 2416 0.300827315147422 766 16413835
SGTC_3081 9117243 49.47 µM -0.523216807581472 0.284778264942215 no 2417 0.30041169319686 774 45595589
SGTC_700 3453-2283 142 µM -0.52447451438066 0.284322881481512 no 2418 0.299974270664251 757 565664
SGTC_1131 3454-3128 32.3 µM -0.526628008877871 0.283543965326625 no 2419 0.299225968834833 748 710982
SGTC_2421 5690543 90.72 µM -0.527253088896008 0.28331806632407 no 2420 0.299008923129598 782 3397993
SGTC_608 k048-0125 159 µM -0.527931174916614 0.283073109004771 no 2421 0.29877355309805 786 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1573 oleylamine 1.06 µM -0.527960983555951 0.283062343021801 no 2422 0.29876320817164 780 5356789 An amine of the fatty acid oleic acid.
SGTC_1970 st070122 35.8 µM -0.529005037081695 0.282685386362934 no 2423 0.298400977825429 792 102928
SGTC_2164 5685496 200 µM -0.530705379331154 0.282071992797507 no 2424 0.297811478873363 771 759046
SGTC_3180 9109287 49.47 µM -0.531403949007091 0.28182017167628 no 2425 0.297569442783051 750 18891271
SGTC_1826 st055655 41.6 µM -0.532977095075286 0.281253479387487 no 2426 0.29702471794907 766 676168
SGTC_407 eburnamonine 100 µM -0.53301806764668 0.281238727247712 no 2427 0.297010536692848 782 3195
SGTC_2242 6630449 61.2675 µM -0.5333627325309 0.281114645739405 no 2428 0.296891254976838 760 691249 YDR170C SEC7
SGTC_1899 st063254 59.6 µM -0.535040750284116 0.280510926937539 no 2429 0.296310839550391 771 3093813
SGTC_2982 9019404 25.97 µM -0.535167943139777 0.280465190970377 no 2430 0.296266865591359 744 22333232
SGTC_2470 5664817 21.68 µM -0.535907203553196 0.280199439425672 no 2431 0.296011342840684 773 2859561
SGTC_120 rhodamine 6G 52.259 µM -0.535928750949307 0.280191695333411 no 2432 0.296003896576858 804 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1168 k815-0004 80.5 µM -0.535960380503949 0.280180327920813 no 2433 0.295992966316362 764 642433
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.537095044055236 0.279772686640906 no 2434 0.295600981975991 781 279621
SGTC_1166 k206-0078 225 µM -0.538196440140549 0.279377272505408 no 2435 0.295220718723948 755 5404595
SGTC_3307 9126885 69.2785 µM -0.540906094034126 0.27840563204203 no 2436 0.294286155148408 762 24824909
SGTC_754 3474-0146 171 µM -0.541354755071247 0.278244908102175 no 2437 0.294131543254464 760 24762078
SGTC_441 propafenone 146 µM -0.541765939230553 0.278097649252507 no 2438 0.29398987914244 770 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2277 7947813 106.88 µM -0.543074681063056 0.277629198098239 no 2439 0.293539192162173 788 1246798
SGTC_1239 0337-0584 35.4 µM -0.54376723391227 0.277381461748044 no 2440 0.293300829611703 773 914301 YML130C ERO1
SGTC_2401 5128683 200 µM -0.54411797470682 0.277256037845318 no 2441 0.293180146022132 798 708373
SGTC_1426 4048-4480 71.7 µM -0.544151569730882 0.277244025816906 no 2442 0.293168587787892 774 14224343
SGTC_2290 7904846 200 µM -0.545811893227733 0.276650688223718 no 2443 0.292597623547043 755 2962154
SGTC_1020 4335-0961 93.3 µM -0.546700872700953 0.276333256170408 no 2444 0.292292127276374 789 669075
SGTC_3100 9120536 49.47 µM -0.547478782899783 0.276055630806755 no 2445 0.292024921542342 792 16421196
SGTC_2351 9026858 72.31 µM -0.547628061063792 0.276002371165947 no 2446 0.291973658732791 783 1409300
SGTC_1275 0867-0008 21.1 µM -0.547952550743904 0.275886616761094 no 2447 0.291862241936881 779 3422836
SGTC_2962 9082311 13.18 µM -0.548920327950265 0.275541525682293 no 2448 0.29153006356891 776 16459453
SGTC_2010 4012422 159 µM -0.550465168495429 0.274991104996044 no 2449 0.291000180522168 770 952393
SGTC_2315 7733312 200 µM -0.550943915155916 0.274820639434437 no 2450 0.290836060947015 761 726316
SGTC_2330 7979373 200 µM -0.551610546207041 0.274583361365693 no 2451 0.29060760465553 767 1863007
SGTC_1802 st050112 57.9 µM -0.552297998613149 0.27433877811568 no 2452 0.290372100798033 774 4662563
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.554020659167292 0.273726359194688 no 2453 0.289782353599562 761 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_637 1181-0519 7.26 µM -0.554432587262047 0.273580015874557 no 2454 0.289641414667055 778 6252091 YGR060W ERG25
SGTC_466 geldanamycin 89.2 µM -0.554564932343987 0.273533006619435 no 2455 0.289596140355515 763 5288382 HSP90 inhibitor.
SGTC_2274 7947094 46.08 µM -0.554730750365394 0.273474113347968 no 2456 0.28953941987905 752 2971028
SGTC_838 0109-0203 71.4 µM -0.556455377098611 0.272861953358372 no 2457 0.288949795626227 751 759422
SGTC_699 0375-0592 111 µM -0.558084876245097 0.272284184237026 no 2458 0.288393213704929 762 762578
SGTC_3183 9108214 49.47 µM -0.558166577517421 0.272255231547854 no 2459 0.288365320617995 770 4974831
SGTC_2540 epiandrosterone 100 µM -0.558377578492157 0.272180465669924 no 2460 0.288293290066017 783 441302 A steroid.
SGTC_348 k064-0012 10.7 µM -0.559033078895817 0.271948261418674 no 2461 0.288069572463973 780 5066323
SGTC_1819 st053448 58.6 µM -0.559156348574526 0.271904605417296 no 2462 0.288027510558117 812 2857616
SGTC_321 4534-3890 65.3 µM -0.561004313763881 0.271250566059964 no 2463 0.287397298227358 780 699746
SGTC_3177 9107506 49.47 µM -0.561436554263064 0.271097698989286 no 2464 0.287249985250447 784 8897194
SGTC_2663 amphotericin b 100 µM -0.561495656222718 0.271076800207245 no 2465 0.28722984533971 772 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_382 3229-0966 23.2 µM -0.563040126805629 0.270530951835787 no 2466 0.286703780079576 800 5722370
SGTC_493 zm226600 134 µM -0.563674810929429 0.270306800425359 no 2467 0.286487731547331 814 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1873 rapamycin 2 nM -0.565894296974156 0.269523675277989 no 2468 0.285732819334946 762 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1667 st014849 34.6 µM -0.566251882019197 0.269397611131959 no 2469 0.285611282751727 792 5348460
SGTC_2142 5622915 118.518 µM -0.567149307611174 0.269081360163217 no 2470 0.285306372684071 761 5322196
SGTC_143 4032-1194 15.74 µM -0.567842358604271 0.268837257950998 no 2471 0.28507100726704 774 1806963
SGTC_2229 7354935 190 µM -0.568209948045549 0.26870783298025 no 2472 0.28494620866251 801 318112
SGTC_40 0327-0103 19.753 µM -0.569535605041209 0.268241341115425 no 2473 0.284496357507847 761 409036
SGTC_1668 st014914 51.6 µM -0.571699431626727 0.2674807780415 no 2474 0.283762809783169 784 2839556
SGTC_2611 pyromycin 23.93 µM -0.574500739985561 0.266497764499089 no 2475 0.282814499974673 785 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_506 n9-isopropylolomoucine 153 µM -0.576523710777528 0.265789017189995 no 2476 0.282130623990799 797 6610355
SGTC_3323 9138564 53.9225 µM -0.576545943466149 0.265781233284244 no 2477 0.282123112537745 767 43912313 YNL103W MET4
SGTC_24 0417-1663 219 µM -0.57788267629268 0.265313441035591 no 2478 0.281671665996202 812 4329390
SGTC_1684 st024538 14.6195 µM -0.578870384111491 0.26496805946466 no 2479 0.281338317439804 779 6732859
SGTC_364 0083-0097 67.7 µM -0.580265964551562 0.264480442803197 no 2480 0.280867637903544 797 5207356
SGTC_2383 9036125 200 µM -0.581457391708918 0.264064519058007 no 2481 0.280466113447802 785 79580
SGTC_2778 tioconazole 65.09 nM -0.582326414406846 0.263761356102591 no 2482 0.280173418305592 811 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2426 5582046 32.21 µM -0.582854981848514 0.263577049533482 no 2483 0.27999546416053 793 2251934
SGTC_2361 9034121 116 µM -0.583032908306767 0.263515023013078 no 2484 0.279935573537243 817 6496917
SGTC_138 0850-0259 40.9225 µM -0.583044997567489 0.26351080887487 no 2485 0.279931504478233 782 6813004
SGTC_1953 st076800 12.1 µM -0.58343910099818 0.26337344906338 no 2486 0.279798871041575 794 297591
SGTC_2619 obliquin 87.91 µM -0.584230391855214 0.263097764983878 no 2487 0.279532658357839 794 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1273 0849-0096 14.1 µM -0.58440206260831 0.263037974723989 no 2488 0.279474919686929 803 5286025
SGTC_2204 7233102 200 µM -0.585590116866779 0.262624384269522 no 2489 0.279075495735943 785 2172480
SGTC_338 4055-0136 114 µM -0.585746439147033 0.262569989482445 no 2490 0.279022960843045 788 2900563
SGTC_2720 fluspirilene 36.88 µM -0.589854350448305 0.261142646926079 no 2491 0.277644150503367 797 3396 An atypical antipsychotic.
SGTC_2092 5303694 80.6725 µM -0.590527298193261 0.26090920396718 no 2492 0.277418594939481 797 1963699
SGTC_1518 st038567 90.8 µM -0.590773388474209 0.260823863012967 no 2493 0.277336133893208 813 77966
SGTC_2008 4012253 172 µM -0.592405852849042 0.260258109106803 no 2494 0.276789424004665 786 603940
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.593158936418431 0.259997330520633 no 2495 0.276537395505929 804 165521
SGTC_997 3996-0078 137 µM -0.593371433859805 0.259923771061705 no 2496 0.276466301031143 782 735687
SGTC_847 0342-0274 5.54 µM -0.594807565808686 0.259426912117514 no 2497 0.275986054837384 789 18097
SGTC_136 0097-0015 404.482 µM -0.59481230970024 0.259425271685465 no 2498 0.275984469147077 796 4861337
SGTC_2217 6934799 96.0675 µM -0.594921528593584 0.259387505404035 no 2499 0.275947962943577 780 675606
SGTC_2863 9028737 58.44 µM -0.59539038051878 0.259225415600042 no 2500 0.27579127704587 792 6460917
SGTC_1830 st055982 50.3 µM -0.59586825589626 0.25906026012947 no 2501 0.275631620598902 828 455313 An antimicrobial agent.
SGTC_3300 9124615 50.48 µM -0.598219190659138 0.258248561496727 no 2502 0.274846844059301 801 24824903
SGTC_631 k072-0230 41.5 µM -0.59889900335866 0.258014091004935 no 2503 0.274620118051019 800 5773147
SGTC_1289 0976-0073 69.1 µM -0.599016391633007 0.257973614437566 no 2504 0.274580976940704 806 3391136
SGTC_1515 3460-0031 42.1 µM -0.599155422037696 0.257925679723788 no 2505 0.274534623192675 795 2876596
SGTC_2166 5933061 31.504 µM -0.599927422154919 0.257659594666687 no 2506 0.274277303000248 787 2877375
SGTC_2353 9059630 146.67 µM -0.601672183513016 0.257058753748367 no 2507 0.27369618475757 785 4779114
SGTC_3356 9151811 4.48 µM -0.603503943440675 0.256428738306896 no 2508 0.273086746475765 818 1859254 YPR165W RHO1
SGTC_1627 st003713 25.6 µM -0.604811870646163 0.255979382703866 no 2509 0.2726520026678 783 16195070 YER133W GLC7
SGTC_1621 st003705 32.4 µM -0.605835537881094 0.255627975169016 no 2510 0.272311984234218 795 24207032
SGTC_1376 2910-0861 41.3 µM -0.606346205585986 0.255452765878199 no 2511 0.272142441081584 817 1112859
SGTC_2369 9071472 200 µM -0.608866483966226 0.254588982202656 no 2512 0.271306470680135 799 17296037
SGTC_2109 5483026 200 µM -0.60902129298648 0.254535973894143 no 2513 0.271255162645199 833 759335
SGTC_2536 dehydroabietamide 32.04 µM -0.609785037600003 0.254274544004606 no 2514 0.271002107153268 789 3983547
SGTC_1958 st076513 41.9 µM -0.611653647136308 0.253635512739562 no 2515 0.270383467977609 806 732122 YGL099W LSG1
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.61220372710572 0.253447555996794 no 2516 0.270201487982066 828 7104
SGTC_3116 9124943 49.47 µM -0.612560274907498 0.253325766341048 no 2517 0.270083565919077 779 41905195 YPL160W CDC60
SGTC_2922 7999257 32.47 µM -0.613624578345348 0.252962404466074 no 2518 0.269731719035636 814 2988377
SGTC_432 NS 1619 61.3 µM -0.618854491455527 0.251180862359922 no 2519 0.268006110363016 790 4552 A K+/calcium channel activator.
SGTC_3150 9097574 49.47 µM -0.618966325999973 0.251142839115896 no 2520 0.267969271368536 799 17217476
SGTC_2099 5377090 177.372 µM -0.619741387860359 0.250879405243468 no 2521 0.267714031261759 817 2243829
SGTC_219 mitoxanthrone 164.414 µM -0.620703587774421 0.250552569094872 no 2522 0.267397334187335 812 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_323 4013-0906 34.3 µM -0.620713744097306 0.250549120440029 no 2523 0.267393992358212 787 2910086
SGTC_1963 st076565 50.3 µM -0.621466894643526 0.250293452677616 no 2524 0.26714623496944 824 4914280
SGTC_2001 4023502 57.655 µM -0.621549119999273 0.250265548477995 no 2525 0.267119193027021 803 108941 YCR052W RSC6
SGTC_2956 9076196 2.52 µM -0.621632856588452 0.250237133117846 no 2526 0.267091655496598 829 16423868
SGTC_3069 9117009 49.47 µM -0.622107039873664 0.250076254989248 no 2527 0.266935743103092 791 41904981
SGTC_964 1287-0107 19.4 µM -0.622552742252198 0.249925089737056 no 2528 0.266789237213209 789 51516812 YPR165W RHO1
SGTC_3137 9097352 49.47 µM -0.622950235030507 0.2497903162663 no 2529 0.266658612487796 851 44120435
SGTC_868 0527-0199 213 µM -0.623529308701028 0.249594045250747 no 2530 0.266468374233109 806 2849450
SGTC_3005 9076496 71.4286 µM -0.62378049283922 0.249508934474777 no 2531 0.266385876151816 808 21368410
SGTC_384 k007-0144 5.16 µM -0.623808779548098 0.249499350824055 no 2532 0.266376586569083 817 6824886
SGTC_2671 danthron 100 µM -0.624046639787975 0.249418770556745 no 2533 0.266298477837887 804 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1008 4106-0037 6 µM -0.624813984120523 0.249158910491956 no 2534 0.266046575748097 827 2905394
SGTC_1754 st042065 16.137 µM -0.628038674057177 0.248068449802953 no 2535 0.264989302662543 810 1126236 YIL048W NEO1
SGTC_1414 3917-0015 5.4 µM -0.628507678319258 0.247910063737038 no 2536 0.264835709128264 813 6618702
SGTC_2675 theaflavin digallate 100 µM -0.628650567462499 0.247861819788757 no 2537 0.264788923563181 814 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_141 0443-0274 32.331 µM -0.629987963939442 0.247410514996419 no 2538 0.264351229522928 780 1627241
SGTC_801 0866-0028 10.1 µM -0.630466001404524 0.247249307737907 no 2539 0.264194870069633 809 6849771
SGTC_2349 9023730 187.07 µM -0.630594103627326 0.247206117721656 no 2540 0.264152977605645 816 4126287
SGTC_2400 5203494 178.7 µM -0.633528255382865 0.246217965847071 no 2541 0.26319436765744 820 6777674
SGTC_2327 6189656 200 µM -0.63444108293773 0.245910979952658 no 2542 0.26289650272082 830 5349088
SGTC_1455 4262-0120 131 µM -0.635587745322028 0.245525646155348 no 2543 0.262522579491146 806 1529587
SGTC_2307 7538926 6.34 µM -0.639461102707159 0.24422641351292 no 2544 0.26126150507043 822 96582
SGTC_881 0833-0569 170 µM -0.643934943567327 0.242730386886567 no 2545 0.259808810593 801 5418700
SGTC_2614 arthonioic acid 13.39 µM -0.644098657759951 0.242675736045807 no 2546 0.259755730347955 816 6710684
SGTC_1345 1488-0192 31.4 µM -0.644588214628738 0.242512352614258 no 2547 0.259597037134765 817 658348
SGTC_44 0929-0055 61.211 µM -0.645670375682404 0.242151406514 no 2548 0.259246424913149 798 1379590
SGTC_258 haloperidol 50.781 µM -0.645761782151998 0.242120931967827 no 2549 0.259216821102281 829 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1335 1486-0900 202 µM -0.647465395762389 0.241553334822365 no 2550 0.258665391734852 808 X1335
SGTC_2960 9079389 5.97 µM -0.64776558357382 0.241453395438404 no 2551 0.258568289259259 798 16457355
SGTC_3247 9135149 49.47 µM -0.64836629634509 0.241253471884762 no 2552 0.258374031947583 821 8934436 YOR116C RPO31
SGTC_2268 7933382 153.85 µM -0.648765417873525 0.241120689784584 no 2553 0.258245006638379 801 935025 YOR257W CDC31
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.648972463514889 0.241051824275746 no 2554 0.258178087481754 820 390807
SGTC_1042 0350-0096 82 µM -0.650705647100393 0.240475769289927 no 2555 0.257618258574226 818 3122515
SGTC_1493 4348-0038 111 µM -0.65191840450179 0.240073133633695 no 2556 0.25722690570019 837 800424
SGTC_1473 k844-0725 134 µM -0.652248696071466 0.239963540490314 no 2557 0.257120375257118 823 54682906
SGTC_2874 9043904 71.43 µM -0.653404259599395 0.239580330901021 no 2558 0.256747846722932 818 4463428
SGTC_1480 1070-0044 41.2 µM -0.653706415521244 0.239480184656582 no 2559 0.256650484589949 817 3124987
SGTC_2047 4141938 200 µM -0.655440645921829 0.23890583546961 no 2560 0.256092044600942 826 3807862
SGTC_1625 st003711 30.1 µM -0.657369260966901 0.238267994895785 no 2561 0.255471755861619 820 24207034 YER133W GLC7
SGTC_2247 cerulenin 830 nM -0.658002890787699 0.238058641647919 no 2562 0.255268136805707 801 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1662 st014054 52 µM -0.661236089589684 0.236991954163418 no 2563 0.254230460104366 820 2838777
SGTC_1461 k072-0203 53.8 µM -0.661596741339236 0.236873132069437 no 2564 0.254114848257044 823 5418714
SGTC_1721 st082152 9.2685 µM -0.6622486269152 0.236658441783285 no 2565 0.253905947417694 835 5296051
SGTC_1728 st035614 33.7865 µM -0.663681344587332 0.236186970683557 no 2566 0.253447140931545 819 15945546
SGTC_2176 5809774 33.9695 µM -0.664340287699219 0.235970303002262 no 2567 0.253236270583458 801 2870539
SGTC_1072 oxiconazole 14.9 nM -0.664427809735369 0.235941533045277 no 2568 0.253208269338054 800 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_562 3772-2733 112 µM -0.665763018255339 0.235502867472232 no 2569 0.252781293159439 810 2876874 YIL048W NEO1
SGTC_2974 9094440 9.66 µM -0.666037005207888 0.235412908263957 no 2570 0.252693723854258 813 25236134
SGTC_1009 4106-0057 9.87 µM -0.666486043295887 0.235265514851435 no 2571 0.252550240796271 817 2928005
SGTC_1955 wogonin 32.4 µM -0.666825868869539 0.235154003513155 no 2572 0.2524416834197 799 5281703 A flavanone.
SGTC_1583 clindamycin 39.6 µM -0.667805287738711 0.234832777555952 no 2573 0.252128945410339 831 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1206 3978-0017 132 µM -0.669583133025547 0.234250307045112 no 2574 0.251561784635242 816 3873677
SGTC_502 l-744,832 89.3 µM -0.670341913987862 0.234001953469848 no 2575 0.251319926893161 842 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_306 1672-3436 11.6 µM -0.67078281911836 0.233857709592339 no 2576 0.251179447017142 847 6797378
SGTC_478 N-arachidonylglycine 10 µM -0.671937934472299 0.233480042718389 no 2577 0.250811604630225 789 5283389
SGTC_1694 st024011 44.9 µM -0.674691699265809 0.232581060846293 no 2578 0.249935829687703 838 2787533
SGTC_3051 9093778 49.47 µM -0.677618056019686 0.231627848169082 no 2579 0.249006947361679 854 17217378
SGTC_3239 9133757 49.47 µM -0.67831902628792 0.231399842269092 no 2580 0.248784718833833 855 17036923
SGTC_1731 st035964 63 µM -0.678987145265382 0.231182638517427 no 2581 0.248573003476377 844 6739575
SGTC_374 0880-0231 82.3 µM -0.68083058055065 0.23058393281127 no 2582 0.247989348816258 833 6833587
SGTC_3040 9091894 49.47 µM -0.682680451699658 0.229984008862239 no 2583 0.247404392386705 792 25236966
SGTC_1637 st007924 17.4 µM -0.683015393075708 0.22987547890983 no 2584 0.247298557909124 819 683336
SGTC_1632 st005650 90 µM -0.683026617614039 0.229871842356181 no 2585 0.247295011608707 825 2759605
SGTC_1442 4112-3290 3 µM -0.683598174463644 0.229686710535441 no 2586 0.247114468875845 843 704353
SGTC_1820 st053765 18.6 µM -0.683796984636935 0.22962233391638 no 2587 0.247051685473656 822 3690829
SGTC_2223 6903751 107.57 µM -0.68445787150139 0.229408405146378 no 2588 0.246843041576955 824 5598863
SGTC_2295 7971645 200 µM -0.684745743127442 0.229315256173475 no 2589 0.246752189170241 829 2978226 YKL099C UTP11
SGTC_1558 st069300 45.6 µM -0.687214859138864 0.228517175595124 no 2590 0.245973671007847 823 24208000
SGTC_578 3460-0051 92 µM -0.688032190019739 0.228253337769915 no 2591 0.245716255277909 856 2876744
SGTC_2607 solasodine 47.35 µM -0.690280229575745 0.227528545099218 no 2592 0.245008989143763 846 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2511 berberine 10.47 µM -0.691726929442769 0.227062799418835 no 2593 0.24455441604434 844 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.69173602692055 0.227059872309216 no 2594 0.244551558929107 839 5377381
SGTC_1288 0973-0013 65.5 µM -0.693262610746432 0.226568996021693 no 2595 0.244072381239847 828 4315430
SGTC_1674 st016616 23.6 µM -0.693290880941441 0.226559911333388 no 2596 0.244063512318222 826 625830
SGTC_445 e6 berbamine 66 µM -0.693626560179389 0.226452055802957 no 2597 0.243958216361486 841 6610268 A calcium/calmodulin antagonist.
SGTC_1337 1486-1011 40.3 µM -0.694548851805509 0.226155867897029 no 2598 0.243669037889545 826 X1337
SGTC_61 0978-8327 98.565 µM -0.694775760053655 0.226083031370985 no 2599 0.243597920680422 848 6150059 YHR072W ERG7
SGTC_2020 4017018 200 µM -0.695652122999508 0.225801847332879 no 2600 0.243323357729272 840 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1937 st074714 47.2 µM -0.695844871460805 0.225740029878712 no 2601 0.243262992424849 820 17250970
SGTC_2464 5717415 7.67 µM -0.695885419846376 0.225727026594513 no 2602 0.243250294440315 825 5285744
SGTC_803 4488-1585 147 µM -0.695980408184958 0.225696566859201 no 2603 0.243220549641454 818 747204
SGTC_2765 myclobutanil 7.74 µM -0.699203549282919 0.224664387238871 no 2604 0.242212416404418 863 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2141 5621638 7.665 µM -0.700384452992011 0.224286885546041 no 2605 0.241843621418975 827 2856238
SGTC_979 1426-2828 121 µM -0.700658002512755 0.224199490859818 no 2606 0.241758235676368 827 747872
SGTC_3231 9132313 49.47 µM -0.701164354586677 0.224037770527467 no 2607 0.241600226130696 835 4905967
SGTC_1229 0139-0193 12.2 µM -0.701837473094404 0.223822890438072 no 2608 0.24139026317913 842 3090752
SGTC_1664 st014217 9.02 µM -0.702312571679507 0.22367129493207 no 2609 0.241242127423133 841 3982782
SGTC_815 1582-0027 36.9 µM -0.703138046618021 0.223408039455519 no 2610 0.240984861845816 856 3128206
SGTC_319 1348-1596 45.5 µM -0.704213996158898 0.223065168926831 no 2611 0.240649758052232 846 5380505
SGTC_2592 piperlongumine 83.33 µM -0.704664715693877 0.222921628203173 no 2612 0.240509457162063 848 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2306 7482397 179.52 µM -0.706876585805886 0.222217976733728 no 2613 0.239821587826974 868 891448
SGTC_2702 st077768 96.8 µM -0.708113557928598 0.221825018058843 no 2614 0.23943737039074 819 6484119
SGTC_20 0481-0013 4.944 µM -0.70813990521192 0.221816652429279 no 2615 0.239429190286427 837 182045
SGTC_954 1189-0853 2.85 µM -0.708749787818473 0.221623056576158 no 2616 0.239239881229917 839 2828194
SGTC_1445 4239-0156 97.7 µM -0.710148042389474 0.221179571406628 no 2617 0.238806168437008 861 4008346
SGTC_2059 5238311 157 µM -0.710421916801191 0.221092766008236 no 2618 0.238721268042584 842 703021
SGTC_1479 0549-0158 134 µM -0.711062156638281 0.220889915951132 no 2619 0.238522859710856 839 5440202
SGTC_860 0443-0016 25.1 µM -0.712301940321442 0.220497412815839 no 2620 0.238138911390762 846 5337942
SGTC_2033 5192550 145 µM -0.713471484533166 0.220127513417362 no 2621 0.237777026168616 821 182073
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.713716520085324 0.220050059541267 no 2622 0.237701244488496 841 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2728 chlorpromazine 9.18 µM -0.714825491264916 0.219699717731991 no 2623 0.237358440813843 884 2726 A thorazine and dopamine antagonist.
SGTC_959 1222-0044 107 µM -0.715355740333273 0.219532316772377 no 2624 0.23719462691782 831 6083612
SGTC_1459 k035-0031 35.7 µM -0.715991808176269 0.219331605250075 no 2625 0.236998203580952 826 3877128 YMR208W ERG12
SGTC_1061 3448-9325 110 µM -0.716124838422733 0.219289640828201 no 2626 0.236957133979465 843 723482
SGTC_3333 9141820 12.094 µM -0.716356742833056 0.219216497563464 no 2627 0.236885548926628 837 1939433
SGTC_2439 5492030 7.2 µM -0.71644184977749 0.21918965812615 no 2628 0.236859280804274 840 5722370
SGTC_1151 3909-8316 15.3 µM -0.716971287570511 0.219022736365415 no 2629 0.236695906651856 845 800431
SGTC_1444 4112-3581 28 µM -0.718317036665553 0.218598776270795 no 2630 0.236280913946147 840 2877249
SGTC_1349 flufenamic acid 69 µM -0.719874139226182 0.218108822205525 no 2631 0.23580124593266 845 3371 A non-steroidal anti-inflammatory.
SGTC_891 0929-0073 133 µM -0.720695324230311 0.217850685286166 no 2632 0.235548494928723 854 5603632
SGTC_1415 3966-0071 78.1 µM -0.723457099157879 0.216983823925378 no 2633 0.234699551009817 840 2893185
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.723535297350793 0.216959308263156 no 2634 0.23467553826722 841 688662
SGTC_2378 9074213 121.43 µM -0.723580127971088 0.216945254282593 no 2635 0.234661772498546 840 657714
SGTC_3339 9145883 14.936 µM -0.723654918991738 0.21692180916771 no 2636 0.234638808030829 829 2030670
SGTC_2017 5132927 60.65 µM -0.724068161048961 0.216792294520234 no 2637 0.23451194510047 833 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_835 0312-0010 67.2 µM -0.725566732669646 0.21632300077452 no 2638 0.234052210697778 859 1626196
SGTC_2241 6772625 37.8075 µM -0.726662331174482 0.215980274814327 no 2639 0.233716417207379 836 2285411
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.728795337988104 0.215313929167109 no 2640 0.233063431878261 845 4330530
SGTC_281 1672-3440 14.9 µM -0.730804451379831 0.214687379893612 no 2641 0.232449302112846 839 6833000
SGTC_386 1509-0011 3.07 µM -0.731115049077113 0.214590613527959 no 2642 0.23235444147129 840 3107280
SGTC_1758 st042942 75.2445 µM -0.734785050118732 0.213449149843493 no 2643 0.231235206640133 853 669317
SGTC_839 0122-0028 230 µM -0.735945922224336 0.213088827168815 no 2644 0.230881804343449 860 759448
SGTC_414 piperonyl butoxide 100 µM -0.736018231666756 0.213066394812449 no 2645 0.23085980128687 840 5794 A potent inhibitor of cytochrome P450.
SGTC_1096 rimcazole 32.2 µM -0.736057857114744 0.213054102504746 no 2646 0.230847744147019 855 18528119 A dopamine reuptake inhibitor.
SGTC_1227 3909-8010 46.6 µM -0.736354335142272 0.212962144455468 no 2647 0.230757543656365 840 15982272
SGTC_1940 st075990 51.1 µM -0.736406037128406 0.212946110516635 no 2648 0.230741815857504 867 1084979
SGTC_715 0868-0130 184 µM -0.736623894950285 0.212878555686533 no 2649 0.230675549855519 865 2876258
SGTC_1366 1683-0113 21.9 µM -0.736712255528762 0.212851159805167 no 2650 0.230648676172926 853 708623
SGTC_2168 5727979 200 µM -0.73903701426125 0.21213111628279 no 2651 0.229942260795718 852 695210
SGTC_823 0417-1665 178 µM -0.739102750595784 0.212110776606894 no 2652 0.229922303373187 871 3429856
SGTC_2566 crystal violet carbinol 226 nM -0.73959977116492 0.211957028893672 no 2653 0.229771440284139 883 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_525 k781-2675 26.7 µM -0.739878118726342 0.211870953694025 no 2654 0.229686976304606 835 3651118 YDL195W SEC31
SGTC_1749 st037932 54.2 µM -0.740103611769377 0.211801238031764 no 2655 0.229618563669408 889 594497
SGTC_3268 9137683 49.47 µM -0.741166369002612 0.211472846237408 no 2656 0.229296286057006 895 1953228
SGTC_1460 k062-0059 9.15 µM -0.742547638280842 0.211046480168809 no 2657 0.2288777999692 839 1373085
SGTC_2403 6032726 181.2 µM -0.743654544337239 0.210705167700556 no 2658 0.228542747918877 861 2881040
SGTC_1607 st000305 50.6 µM -0.744915832837143 0.21031664666712 no 2659 0.228161301530384 860 5457690
SGTC_3087 9117406 49.47 µM -0.745195566882734 0.210230535810249 no 2660 0.228076751216985 839 42546093
SGTC_539 4859-0462 2.54 µM -0.745783349444599 0.210049665497882 no 2661 0.227899149893773 840 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_216 k038-0035 28.382 µM -0.746348046597281 0.209875985085045 no 2662 0.2277285972479 851 4444231 YPR107C YTH1
SGTC_1554 st069299 38.7 µM -0.750700144612823 0.208540271918316 no 2663 0.226416567990425 819 24207999
SGTC_1357 1503-1303 39.5 µM -0.750992245343656 0.208450802412922 no 2664 0.226328661365356 840 292895
SGTC_920 mycophenolic acid 780.421 nM -0.752203273688669 0.20808010991229 no 2665 0.22596441262251 844 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_23 0213-0011 39.996 µM -0.752247301626698 0.208066640413649 no 2666 0.225951176304543 870 627608
SGTC_362 0310-0100 9.03 µM -0.752789121671008 0.207900923160699 no 2667 0.225788322392013 842 790235
SGTC_310 1273-0058 1.06 µM -0.753708912754297 0.207619780875306 no 2668 0.225512014451168 823 2734232
SGTC_87 0100-0052 35.5 µM -0.754284468486002 0.20744397149313 no 2669 0.225339213213275 871 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2700 st077718 96.8 µM -0.75487742241911 0.207262939715242 no 2670 0.225161266886407 855 904970
SGTC_668 1682-0499 62.6 µM -0.755409619420118 0.207100536913466 no 2671 0.22500162161239 865 682214
SGTC_2518 prenyletin 46.28 µM -0.755503550444255 0.20707188116978 no 2672 0.224973451407142 828 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_342 k048-0088 23.3 µM -0.756457363837922 0.206781032096575 no 2673 0.224687513044328 865 6820570
SGTC_1327 1436-0082 2.18 µM -0.758912757037959 0.206033415503584 no 2674 0.223952373582829 866 15992205
SGTC_105 0111-0055 734.78 µM -0.759073496041671 0.205984529759512 no 2675 0.223904296378712 858 5179370
SGTC_193 1273-0060 1.558 µM -0.759881673470211 0.205738842068903 no 2676 0.223662658562323 851 2847393 YHR072W ERG7
SGTC_297 0986-0032 24 µM -0.76113696996907 0.205357574235766 no 2677 0.223287630332512 853 2847425
SGTC_2750 bromebric acid 70.15 µM -0.762004015202052 0.205094474127649 no 2678 0.22302880387386 866 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1682 st012968 530 nM -0.762294413815342 0.205006399070058 no 2679 0.222942153592737 851 24207270
SGTC_2264 7948757 110.76 µM -0.762805141938504 0.20485155478155 no 2680 0.222789807054858 849 2971411
SGTC_1338 1486-1223 76 µM -0.76418972492508 0.204432122199144 no 2681 0.222377094421154 852 3444526
SGTC_2697 mebhydrolin 72.4 µM -0.766468182242947 0.203743021473691 no 2682 0.221698888438137 876 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_897 1000-0139 31.4 µM -0.766798067765971 0.203643365191112 no 2683 0.221600792693767 870 6151020
SGTC_2948 9070189 9.45 µM -0.767452033797874 0.203445892228451 no 2684 0.22140640075016 814 6473636 YDL196W YDL196W
SGTC_900 1112-0045 141 µM -0.769272748693412 0.202896707407467 no 2685 0.220865705651919 844 56211 YIL048W NEO1
SGTC_518 1021-0119 62.6 µM -0.770604912525685 0.202495446483292 no 2686 0.220470574248689 874 1097762
SGTC_2423 st077119 87.2 µM -0.770871671400119 0.202415153122377 no 2687 0.220391499952658 848 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2147 5545932 89.7195 µM -0.771880073015671 0.202111800297316 no 2688 0.220092730301526 870 797404
SGTC_2358 9037157 4 µM -0.772188624998836 0.202019034403486 no 2689 0.220001358832077 859 2388925
SGTC_2731 amoxapine 43.43 µM -0.772912437331817 0.201801520864677 no 2690 0.219787101785469 892 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_665 3914-0008 307 µM -0.776154806544137 0.200828875813891 no 2691 0.218828793329045 870 1069549
SGTC_1902 st060212 70.5 µM -0.776466686412064 0.200735466726598 no 2692 0.218736741631174 849 688944
SGTC_2131 toluylene red 5.2905 µM -0.776665249591645 0.200676009964352 no 2693 0.218678147095207 838 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2233 sulbentine 40.3845 µM -0.780631232924992 0.199490671513017 no 2694 0.217509708300019 853 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_353 1988-1175 58.3 µM -0.780762206856014 0.199451598530877 no 2695 0.217471182964671 872 2788357
SGTC_73 0327-0325 16.231 µM -0.78194670255177 0.199098441461999 no 2696 0.21712294834681 824 53298
SGTC_817 1391-0715 46 µM -0.782350848006351 0.198978031854475 no 2697 0.217004205766415 875 1353946
SGTC_1651 st011928 86.1 µM -0.784123724683746 0.198450346203181 no 2698 0.216483757838526 877 720198
SGTC_2704 st078022 71.1 µM -0.784479992447515 0.198344407304516 no 2699 0.21637925864482 872 54697681
SGTC_1775 st081588 35.1725 µM -0.785584747867881 0.198016117037806 no 2700 0.216055401409616 866 1426443 YGL099W LSG1
SGTC_791 1348-1292 225 µM -0.786069990231617 0.197872025695563 no 2701 0.215913242200395 880 5437054
SGTC_1633 st005664 67.9 µM -0.786196275729832 0.197834535965602 no 2702 0.215876253812682 875 2063822
SGTC_133 0724-0033 378.92 µM -0.787623837398577 0.197411041545255 no 2703 0.215458383613086 860 280309
SGTC_1474 0330-0125 5.35 µM -0.788642642499286 0.197109142628531 no 2704 0.215160450145593 877 X1474
SGTC_1470 k295-0292 231 µM -0.790550251756309 0.196544619361542 no 2705 0.214603243496899 877 5045612
SGTC_666 0272-0154 136 µM -0.790751180850824 0.196485215024672 no 2706 0.214544601607886 872 6870312
SGTC_1991 st073000 8.92 µM -0.791047139223245 0.19639773526551 no 2707 0.214458242045745 883 4301969 YIL048W NEO1
SGTC_1139 k015-0024 46.9 µM -0.792942225003895 0.195838143077354 no 2708 0.213905742281826 875 2766652
SGTC_3022 9087993 49.47 µM -0.79446773951143 0.195388383795304 no 2709 0.213461591259214 879 17173644
SGTC_59 0330-0160 1.33 µM -0.794837316364739 0.1952795179191 no 2710 0.213354070508795 879 4293482
SGTC_1281 0884-0031 11.8 µM -0.79625023381636 0.194863656171524 no 2711 0.212943302562478 875 1548255
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.796273314060783 0.194856867473801 no 2712 0.212936596432083 890 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2691 st077356 60.2 µM -0.797601331638416 0.194466493875808 no 2713 0.212550939013863 898 2839272
SGTC_1782 st039423 80.636 µM -0.798312283114545 0.194257703954811 no 2714 0.212344645886434 876 2068169
SGTC_702 1488-0190 94 µM -0.798957121628163 0.194068447984116 no 2715 0.212157637645402 844 949357
SGTC_1164 k060-0068 93.7 µM -0.799285046334578 0.193972247287079 no 2716 0.212062573845875 871 5963676
SGTC_1995 st072814 61.1 µM -0.800786932903395 0.193532022043793 no 2717 0.211627502535304 875 5769371
SGTC_2481 5478948 45.16 µM -0.804762622583019 0.192369633463409 no 2718 0.210478337298098 864 77792
SGTC_3187 9109394 49.47 µM -0.805979282925313 0.192014768442319 no 2719 0.210127397315487 867 17098090
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.806093656477899 0.19198142956131 no 2720 0.210094424483809 854 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1284 0929-0043 16 µM -0.806206281213551 0.191948603907109 no 2721 0.210061958790242 877 1239883
SGTC_2718 lomofungin 53.02 µM -0.806939465172096 0.191734993779923 no 2722 0.209850680073103 868 5351222 A RNA synthesis inhibitor.
SGTC_1669 st015249 58.4 µM -0.807481986627046 0.191577026133912 no 2723 0.20969442425599 884 722793
SGTC_1119 parthenolide 318.541 nM -0.807872300999664 0.191463426419659 no 2724 0.209582049111529 911 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_128 0906-2981 13.371 µM -0.808106464380734 0.191395293750439 no 2725 0.209514648295429 874 6740226
SGTC_1904 st060225 78 µM -0.808267038945554 0.191348581226402 no 2726 0.209468436412713 851 66595
SGTC_1267 0828-0272 9.49 µM -0.808745476318065 0.191209441103105 no 2727 0.209330782094982 875 745334
SGTC_485 niflumic acid 177 µM -0.811231713850968 0.19048738761872 no 2728 0.208616308220554 881 4488 A COX2 inhibitor.
SGTC_251 melphalan 456.522 µM -0.811486225880662 0.190413566780008 no 2729 0.208543249911264 871 460612 A DNA alkylator.
SGTC_2331 7980721 200 µM -0.812956973547218 0.189987322784464 no 2730 0.208121363698457 866 2981221
SGTC_1428 4049-0204 61.7 µM -0.813991021125604 0.189687992233799 no 2731 0.207825047373981 888 X1428
SGTC_1261 0712-0010 12.7 µM -0.81459489989704 0.189513318887234 no 2732 0.207652115380292 876 2840123
SGTC_887 0885-0007 9.62 µM -0.816183007836551 0.189054427554411 no 2733 0.207197736917157 886 5719458
SGTC_2225 6654152 15.4 µM -0.818389546885847 0.188417974805212 no 2734 0.206567394307891 865 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_311 1315-0136 58 µM -0.818863840225485 0.188281342685471 no 2735 0.206432051263861 872 6759207
SGTC_943 3253-1379 105 µM -0.819673228053422 0.188048319383795 no 2736 0.206201207949803 867 668464
SGTC_1021 4476-0760 85.3 µM -0.8205634661067 0.187792224927465 no 2737 0.205947482365322 895 746768
SGTC_2888 9058547 12.99 µM -0.820590137746147 0.187784555631527 no 2738 0.205939883574512 870 16476514
SGTC_1398 3558-0053 112 µM -0.822116428161435 0.187346000809427 no 2739 0.205505318226014 856 4532369
SGTC_3212 9128307 49.47 µM -0.822331641060436 0.187284213843531 no 2740 0.205444086647165 883 27243542
SGTC_1768 st044301 37.178 µM -0.822733332553526 0.187168923151759 no 2741 0.20532982785497 913 3931349
SGTC_429 1112-0049 25.5 µM -0.823000455368921 0.187092279727917 no 2742 0.205253867235689 888 2836170
SGTC_1968 st069590 43.6 µM -0.827252220454027 0.185874969444942 no 2743 0.204047059425026 876 6384066
SGTC_2552 juarezic acid 87.02 µM -0.827327433184719 0.185853479818795 no 2744 0.204025749397332 873 1549512
SGTC_253 dyclonine 31.25 µM -0.82828785781203 0.185579204754147 no 2745 0.203753748813562 866 3180 An oral anasthetic.
SGTC_3020 9089140 49.47 µM -0.829269126905609 0.185299236549691 no 2746 0.203476068281717 895 17217859
SGTC_3158 9100007 49.47 µM -0.829296122068953 0.185291538204289 no 2747 0.203468432354718 896 19297233
SGTC_2262 9014885 67.46 µM -0.83371481033241 0.184034116448746 no 2748 0.202220855162013 879 6457424
SGTC_2157 5649910 96.377 µM -0.835612564121395 0.183495709235292 no 2749 0.201686449116243 892 2858091
SGTC_2757 clomiphene 4.22 µM -0.83569178760067 0.18347325429982 no 2750 0.201664158252485 891 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1160 4092-0570 10.5 µM -0.838241963801749 0.182751352930733 no 2751 0.200947411664496 889 4994975
SGTC_1172 0370-0043 85 µM -0.838399188047664 0.182706904154492 no 2752 0.200903272658701 892 376585
SGTC_3294 9122953 26.2835 µM -0.839419695897933 0.182418561080753 no 2753 0.200616917571941 887 16459826
SGTC_946 3434-1334 87.4 µM -0.843722853224277 0.181205839267042 no 2754 0.199412147000334 874 4047976
SGTC_2773 thioridazine 9.09 µM -0.843780277548362 0.181189690081415 no 2755 0.199396099211177 891 5452 An antipsychotic.
SGTC_269 exalamide 29 µM -0.844439000036802 0.181004504989879 no 2756 0.199212068388864 891 3316 A derivative of salicylamide.
SGTC_1397 3532-0190 20.1 µM -0.845238205180274 0.180779985634814 no 2757 0.198988927582687 849 5322280
SGTC_1681 tripelennamine 100 µM -0.849105501739402 0.179696020550292 no 2758 0.197911294640475 858 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1344 1488-0097 29.1 µM -0.849854190088566 0.179486643377428 no 2759 0.197703078586074 889 747966
SGTC_121 0557-0495 61.343 µM -0.850735495704941 0.179240375228964 no 2760 0.197458150348245 904 3104427
SGTC_1933 st074711 15.9 µM -0.85253380009772 0.178738524584482 no 2761 0.19695894369792 878 17250958
SGTC_317 4495-0002 170 µM -0.853193126847432 0.17855474890372 no 2762 0.196776107134745 884 15991618
SGTC_1702 st027038 51 µM -0.853462731735498 0.17847963559854 no 2763 0.196701373167952 886 5521182
SGTC_13 0199-0087 65 µM -0.853671996381148 0.178421347117208 no 2764 0.19664337725499 891 4589825
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.85475280651552 0.178120489697712 no 2765 0.196344004878877 904 5106787 A p450 inhibitor.
SGTC_3254 9136651 49.47 µM -0.854785808956521 0.178111308077769 no 2766 0.19633486791902 916 16454030
SGTC_956 1185-0240 191 µM -0.855158548458176 0.178007628813992 no 2767 0.196231690240037 894 1416193
SGTC_2324 6149169 200 µM -0.857272889890962 0.177420235079602 no 2768 0.195647043733715 883 2888231
SGTC_2066 5222451 176 µM -0.85752899582547 0.177349168434739 no 2769 0.195576298551152 874 2281147
SGTC_2714 st079313 56.9 µM -0.857705887175368 0.177300093481792 no 2770 0.195527444205668 884 2939799
SGTC_1806 st050005 60.3 µM -0.858725324185815 0.177017438291113 no 2771 0.195246037704931 872 5194765
SGTC_1016 4226-1401 38 µM -0.859488729591554 0.176805958493291 no 2772 0.195035467683743 881 2901613
SGTC_16 erodoxin 22.806 µM -0.860150463315099 0.176622773221403 no 2773 0.194853053499786 871 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1027 k015-0025 8.67 µM -0.861173778648919 0.176339729062673 no 2774 0.194571169743305 894 3598955
SGTC_912 3474-0017 2.18 µM -0.862811743367804 0.175887273517541 no 2775 0.194120490712358 886 3360550
SGTC_123 0083-0120 66.675 µM -0.864459490784175 0.175432858224021 no 2776 0.193667762202215 912 16001701
SGTC_1959 st077091 55.8 µM -0.864469459321682 0.175430111370475 no 2777 0.193665025247359 884 821356 YKL052C ASK1
SGTC_1326 1431-2094 10.8 µM -0.864510048494819 0.175418927211533 no 2778 0.193653881355203 903 616278
SGTC_1182 1222-0449 220 µM -0.864832138879515 0.175330192721121 no 2779 0.193565464234895 889 658318
SGTC_980 1473-0395 201 µM -0.865270533251488 0.175209462730175 no 2780 0.19344516004445 893 768876
SGTC_356 1634-0012 32.5 µM -0.865351463373383 0.175187181045896 no 2781 0.19342295618785 898 735457
SGTC_604 1000-0114 314 µM -0.86548344444783 0.175150847866792 no 2782 0.193386749410578 903 1572745
SGTC_3232 9132874 49.47 µM -0.865904807529607 0.175034882466388 no 2783 0.19327118324893 877 3784940
SGTC_207 4185-0010 4.486 µM -0.867943870196517 0.174474390471194 no 2784 0.192712530531456 883 3761753
SGTC_247 mechlorethamine 29.705 µM -0.868979167332248 0.174190247648677 no 2785 0.192429262798521 869 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_3282 9108498 15.4605 µM -0.869260502027476 0.174113084686252 no 2786 0.192352330802025 913 16459645
SGTC_2864 9034755 47.6 µM -0.869844005387155 0.17395311380865 no 2787 0.192192829655269 886 4930451
SGTC_199 4063-0024 41.6 µM -0.872647721451288 0.173185762487188 no 2788 0.191427560435918 882 306215
SGTC_397 arbidol 50 µM -0.873368298723666 0.172988895853445 no 2789 0.191231182189774 890 131410 A RNA synthesis inhibitor.
SGTC_2044 5102272 200 µM -0.873954536292978 0.172828836969228 no 2790 0.191071506560088 891 592666
SGTC_622 1348-1566 26.3 µM -0.874025308042861 0.172809520733461 no 2791 0.191052235737233 896 7340407
SGTC_1433 4060-0023 7.6 µM -0.875021375485202 0.172537802953382 no 2792 0.190781137599302 892 3840627
SGTC_636 0kpi-0074 126 µM -0.875264441228484 0.172471538293121 no 2793 0.190715018617974 900 616434
SGTC_2320 7373003 200 µM -0.87528883747369 0.172464888277423 no 2794 0.190708383104161 887 5415828
SGTC_1402 3909-7673 35.9 µM -0.878308278089859 0.171643101170726 no 2795 0.189888222327389 877 5328014
SGTC_3218 9131285 49.47 µM -0.878745834683216 0.171524221293307 no 2796 0.189769550417668 897 17156417
SGTC_1769 st044406 64.4 µM -0.87924654697488 0.171388247195879 no 2797 0.189633805708848 919 670903
SGTC_3054 9094397 49.47 µM -0.879408604934265 0.171344253283101 no 2798 0.189589884074043 909 2598354
SGTC_3130 9127414 49.47 µM -0.880888038422525 0.170942964933848 no 2799 0.189189211156519 899 1494646
SGTC_1896 st058441 89 µM -0.88169592672213 0.170724083622721 no 2800 0.188970632160433 886 688759
SGTC_2561 acetosyringone 100 µM -0.882294545287668 0.170562015551416 no 2801 0.188808772725143 908 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1354 1498-1681 81 µM -0.882347689059409 0.170547632339318 no 2802 0.188794407403181 909 5754243
SGTC_468 gf-109203x 121 µM -0.8828478697009 0.170412297911701 no 2803 0.188659236306263 899 2396 A protein kinase C inhibitor.
SGTC_2219 9098279 200 µM -0.883393236115085 0.170264815924094 no 2804 0.188511922006645 867 902349
SGTC_11 0438-0307 1.3 µM -0.884697219965133 0.169912514658004 no 2805 0.188159977741226 917 4011476
SGTC_307 1501-1223 22.3 µM -0.885683359681868 0.169646396889995 no 2806 0.187894088834267 895 2830329
SGTC_2424 5537928 59.2 µM -0.887804696188251 0.169074843800151 no 2807 0.187322908182349 893 5382802
SGTC_1588 farnesol 29.9 µM -0.888628579543409 0.168853198164338 no 2808 0.18710136311712 890 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1609 st001574 46.4 µM -0.889551753545498 0.168605062704671 no 2809 0.18685331108479 901 3960012
SGTC_1676 st018489 23.4 µM -0.89150665809213 0.168080387553541 no 2810 0.186328710623575 894 3696235
SGTC_1745 st081495 74 µM -0.892402220239798 0.167840379681972 no 2811 0.186088690751975 876 13842402 YBL026W LSM2
SGTC_204 PMA1.184 62.41 µM -0.892640529126388 0.167776550827853 no 2812 0.186024853817112 896 2252213 YGL008C PMA1
SGTC_232 clozapine 119 µM -0.89288552475653 0.167710947286587 no 2813 0.185959239827507 900 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_371 0195-0006 7.36 µM -0.895474956656935 0.16701857408173 no 2814 0.185266623610398 885 3928593
SGTC_1687 st020778 55.3625 µM -0.896084177192977 0.166855946363905 no 2815 0.18510390355418 896 4259299
SGTC_2539 epi(13)torulosol 80 µM -0.896941267947741 0.166627324207573 no 2816 0.184875128839389 894 6708597
SGTC_1425 4048-4433 7.33 µM -0.897658093574532 0.166436271983261 no 2817 0.184683928702463 949 23734946
SGTC_1784 st039334 36.3 µM -0.90056032911109 0.165664198691557 no 2818 0.183911067630789 921 3496984
SGTC_1257 0669-0121 16 µM -0.901448105261149 0.165428489488317 no 2819 0.183675057014363 893 4307855
SGTC_2890 9046729 58.44 µM -0.906747200324351 0.164026067276546 no 2820 0.182270248459755 899 903329
SGTC_2181 6316240 54.2555 µM -0.908225050693314 0.16363632903596 no 2821 0.18187966574115 916 12779990
SGTC_144 4161-2749 112.381 µM -0.909645127199154 0.163262393816902 no 2822 0.181504845714915 893 797501 YMR168C CEP3
SGTC_797 k781-0471 270 µM -0.910470175085586 0.16304539700535 no 2823 0.181287301867716 889 23738129
SGTC_3351 9150312 21.596 µM -0.911653713783028 0.162734440623737 no 2824 0.180975518488448 907 4904905
SGTC_160 3453-0671 289.699 µM -0.91252725075878 0.162505179948752 no 2825 0.180745615507774 924 5322268
SGTC_1950 st077106 7.18 µM -0.916335126104053 0.161508255373539 no 2826 0.179745574956882 894 13831864
SGTC_1671 st016596 74.5 µM -0.919325246157067 0.1607282249961 no 2827 0.178962738270595 907 2829167
SGTC_1290 0986-0249 10.2 µM -0.920377788865717 0.16045423533846 no 2828 0.178687685713647 906 53329
SGTC_2171 5739187 198.077 µM -0.920629502587071 0.160388756440382 no 2829 0.17862194684222 888 2262761
SGTC_1466 k213-0079 57.5 µM -0.923221645529368 0.159715471938454 no 2830 0.177945855461034 928 3657981
SGTC_546 peri-Naphthalide 147 µM -0.924358976477796 0.159420645585434 no 2831 0.177649723042987 882 223824 A penicillin ester.
SGTC_1368 1852-0141 284 µM -0.92481892816469 0.159301515155577 no 2832 0.177530051535012 913 2838987
SGTC_2662 daunorubicin 22.37 µM -0.924889951926383 0.159283124744146 no 2833 0.177511576911435 869 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1925 st057770 10.1 µM -0.925638325977681 0.159089430350975 no 2834 0.177316984432223 912 5989122
SGTC_3248 9135562 49.47 µM -0.927697202826847 0.158557347785394 no 2835 0.176782329921847 906 17650701
SGTC_2003 4023581 200 µM -0.928312976727377 0.158398438217591 no 2836 0.176622622329909 907 16641307
SGTC_91 0417-1751 58.384 µM -0.929861318747381 0.15799932743967 no 2837 0.176221446438938 929 6795624
SGTC_1351 1496-0003 46.5 µM -0.930496762532618 0.157835722531992 no 2838 0.176056969796332 915 3891978
SGTC_2949 9072542 2.23 µM -0.931808196300252 0.157498425335216 no 2839 0.175717829022201 939 16457352
SGTC_1529 apigenin 74 µM -0.933153225695308 0.157152979844988 no 2840 0.175370430546652 903 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2601 securinine 100 µM -0.93419126337275 0.156886720306886 no 2841 0.175102620782793 918 442872 A GABA receptor antagonist.
SGTC_3008 9078912 71.4286 µM -0.934255863208372 0.156870160086435 no 2842 0.175085962850784 931 16648731
SGTC_167 3672-0051 66.205 µM -0.936499318092249 0.156295762170023 no 2843 0.174508081751153 900 3237971
SGTC_2434 5670830 169.91 µM -0.937200112512034 0.156116620184432 no 2844 0.17432781596587 949 1549830
SGTC_2030 5175110 200 µM -0.938582718421784 0.15576358570083 no 2845 0.173972514495474 933 2831986
SGTC_1076 itraconazole 331 nM -0.939375781816154 0.155561322718334 no 2846 0.173768921351825 912 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1485 3909-9022 254 µM -0.941779504060368 0.154949335929124 no 2847 0.173152770367574 933 714516
SGTC_2665 lovastatin 100 µM -0.943153439009008 0.154600247744145 no 2848 0.172801212594181 921 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2477 5967686 25.23 µM -0.943333531234905 0.15455452862967 no 2849 0.172755164958622 928 776118
SGTC_739 1486-1183 203 µM -0.94470227399766 0.154207344812757 no 2850 0.172405447885828 912 4346692
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.947261518275375 0.153559573290215 no 2851 0.171752767304387 929 23847180
SGTC_2022 5136654 200 µM -0.948275673262026 0.153303379276223 no 2852 0.1714945659236 932 1713771
SGTC_1467 k284-1082 293 µM -0.950050997569104 0.152855582186313 no 2853 0.171043170228047 914 3334705
SGTC_406 estrone 100 µM -0.951306162673691 0.152539510835388 no 2854 0.170724489745256 901 5870 A steroid.
SGTC_889 0919-1524 82.7 µM -0.955450907706894 0.151498877763519 no 2855 0.169674860123528 919 3905452
SGTC_519 k048-0011 62.8 µM -0.955870567009357 0.151393776465431 no 2856 0.169568815398307 898 6836379
SGTC_2817 7995342 71.43 µM -0.955931425339827 0.151378538867439 no 2857 0.16955344049044 946 18879975
SGTC_1526 st051518 75 µM -0.956298432180193 0.151286669984046 no 2858 0.169460740898159 924 673993
SGTC_1604 st002052 72.4 µM -0.957579400095446 0.150966309684241 no 2859 0.169137445428648 911 6254834 YHR062C RPP1
SGTC_1346 1488-2224 62.4 µM -0.959612624318295 0.150458743525753 no 2860 0.168625106490456 900 3722427
SGTC_272 doxorubicin 8.13 µM -0.961044374177042 0.150102009991956 no 2861 0.168264928365893 927 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1789 tunicamycin 25 nM -0.967460908231337 0.148510202505614 no 2862 0.166656837185632 909 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1868 st057644 42.7 µM -0.968014841931145 0.148373314437304 no 2863 0.166518478681485 938 688665
SGTC_940 3232-1287 54.8 µM -0.968746521472779 0.148192631222024 no 2864 0.166335837489885 928 1585493 YIL048W NEO1
SGTC_3153 9100258 49.47 µM -0.971633941781952 0.147481039991394 no 2865 0.165616345308514 934 25236848
SGTC_1214 0358-0031 63.7 µM -0.972275142665696 0.147323330186822 no 2866 0.165456843310517 950 4301366
SGTC_768 0384-0033 77.3 µM -0.973151243523374 0.147108027156554 no 2867 0.165239069445992 904 3965305 YMR134W ERG29
SGTC_2677 mitomycin C 100 µM -0.973737423396052 0.146964090474335 no 2868 0.165093465356387 952 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1839 st053978 48 µM -0.974135260971936 0.146866455134559 no 2869 0.164994691862493 945 3788398
SGTC_2469 5655019 90.81 µM -0.974830514368522 0.146695933947112 no 2870 0.16482216906362 922 2788239
SGTC_550 4123-0385 25.7 µM -0.975567314489384 0.146515367858453 no 2871 0.164639464278657 932 5731123
SGTC_2040 5100729 123 µM -0.978437574827906 0.145813382084458 no 2872 0.163928975909346 923 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2070 5230947 200 µM -0.980030302297216 0.145424822116042 no 2873 0.163535580544201 932 2835538
SGTC_1438 4092-1045 4 µM -0.981962119097594 0.144954473740837 no 2874 0.163059255320167 915 1351342
SGTC_1840 st055363 71 µM -0.983322859020164 0.144623783513797 no 2875 0.162724281551932 951 676033
SGTC_2300 7976697 71.57 µM -0.987544577765726 0.143601047712749 no 2876 0.161687870359013 904 2236109
SGTC_2681 menadione 3.18 µM -0.99066837525616 0.14284743939175 no 2877 0.1609237690895 935 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3318 9139014 38.6185 µM -0.994177044368259 0.142004174528033 no 2878 0.160068340929271 930 16643984
SGTC_1064 honokiol 6.76 µM -0.998139502618949 0.141055906678416 no 2879 0.159105858615318 938 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1233 0325-0408 14.2 µM -0.999773459613766 0.140666132873267 no 2880 0.158710076281882 926 12874
SGTC_3164 9100705 49.47 µM -1.00153746662528 0.140246157430928 no 2881 0.158283518003739 900 17174235
SGTC_2137 5261020 140 µM -1.00165995065958 0.140217028039883 no 2882 0.158253927834986 914 763655
SGTC_2743 auranofin 4.32 µM -1.00301908104056 0.139894072817191 no 2883 0.157925827466484 907 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_571 k831-0106 44.2 µM -1.00458400344593 0.139522844127186 no 2884 0.157548601563567 910 4783639
SGTC_2908 7930301 100 µM -1.00847782977216 0.138602065750004 no 2885 0.156612562868399 910 2223178
SGTC_1695 st026914 34.495 µM -1.0085976832249 0.138573789671484 no 2886 0.156583809439304 940 3289191
SGTC_1360 1598-0022 39.8 µM -1.01046371688938 0.138134058020469 no 2887 0.156136587144582 931 761525
SGTC_1036 k216-0215 33.5 µM -1.01198627976202 0.137775971047952 no 2888 0.155772306794128 873 622330
SGTC_3166 9102297 49.47 µM -1.01472641003957 0.137133124967832 no 2889 0.155118130630104 935 25237072
SGTC_2220 6782180 200 µM -1.01476895836671 0.13712315913417 no 2890 0.155107987003632 914 833803
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.01510644416468 0.137044129432575 no 2891 0.155027545068008 916 3256 An antibiotic and ribosome inhibitor.
SGTC_672 1441-0018 53.7 µM -1.01539356511245 0.136976918271357 no 2892 0.154959129614424 919 251141
SGTC_173 1273-0061 2.693 µM -1.01567381252085 0.136911337839659 no 2893 0.154892371226925 908 2847414 YPL266W DIM1
SGTC_2259 7964009 200 µM -1.01578414671722 0.136885524526604 no 2894 0.154866093473718 930 313134
SGTC_788 1182-0090 188 µM -1.0162710886623 0.136771641423941 no 2895 0.154750156082577 928 5715185
SGTC_1410 3909-8106 77.9 µM -1.01704497627688 0.136590782464635 no 2896 0.1545660170006 926 1039210
SGTC_761 k216-0224 480 µM -1.01752425305429 0.136478856642777 no 2897 0.154452050365903 963 1340404
SGTC_907 3448-6986 75.5 µM -1.01843562188789 0.136266197177362 no 2898 0.15423549038144 944 590582
SGTC_380 3970-0968 6 µM -1.01890493495891 0.136156775813247 no 2899 0.154124050309652 924 2891601
SGTC_955 1216-0110 33 µM -1.02012893365107 0.135871680845776 no 2900 0.15383365809482 934 3619719
SGTC_2680 butyl paraben 22.24 µM -1.02036300699343 0.135817206849042 no 2901 0.153778165752111 960 7184 An antifungal and steroid mimetic.
SGTC_1767 st044992 70.3 µM -1.02165763677564 0.135516188265301 no 2902 0.15347148402759 937 9600693
SGTC_2666 tannic acid 100 µM -1.02387224904764 0.135002322081394 no 2903 0.152947809671846 917 16134267 A thiamine antagonist.
SGTC_2742 clothiapine 36.27 µM -1.02483181369885 0.134780085601867 no 2904 0.152721276220997 923 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_517 1365-0151 113 µM -1.02483633465341 0.134779039137098 no 2905 0.15272020944375 943 768657
SGTC_2289 7946404 165.07 µM -1.02735717414044 0.134196408786171 no 2906 0.152126154709152 920 1246120 YPR165W RHO1
SGTC_2276 7947513 42.08 µM -1.02817665971556 0.134007377913867 no 2907 0.151933367729574 950 2105100
SGTC_2495 cafestol 54.53 µM -1.02863676512313 0.133901325561203 no 2908 0.151825197423375 936 16667697 An anti-infammatory.
SGTC_1513 0337-0559 19 µM -1.02883913301777 0.133854698885263 no 2909 0.151777637146926 929 775073
SGTC_289 k017-0060 526 µM -1.02948349017269 0.133706309793837 no 2910 0.151626267002341 939 5512909
SGTC_452 diindolylmethane 8 µM -1.03242306768819 0.133030789214436 no 2911 0.150936985119895 943 3071 Inhibits expression of several cancer promoting factors.
SGTC_246 cycloheximide 667 µM -1.03280516892497 0.132943154453991 no 2912 0.150847542160244 923 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_69 0096-0274 206.684 µM -1.0339884044119 0.132672032023947 no 2913 0.150570792065292 957 6741392
SGTC_244 nsc-207895 1.295 µM -1.03682718068516 0.132023118560028 no 2914 0.149908202864726 898 42640
SGTC_2947 9072639 7.68 µM -1.03778574321231 0.131804496723725 no 2915 0.1496849078314 974 16488146
SGTC_2385 9074692 200 µM -1.03987570710429 0.131328699558245 no 2916 0.149198825064492 931 17046906
SGTC_2080 5212524 12.4 µM -1.0442201271685 0.130343455827156 no 2917 0.148191778471942 921 260183
SGTC_217 ketoconazole 989 nM -1.04675325133528 0.129771350177035 no 2918 0.147606698260491 901 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_3326 9140064 16.379 µM -1.0469991582062 0.129715904893301 no 2919 0.14754998321865 954 1868434
SGTC_833 3852-0053 558 µM -1.04869194792879 0.129334672235385 no 2920 0.147159960692292 970 3123681
SGTC_544 k015-0020 52.4 µM -1.05147748753191 0.128709033258933 no 2921 0.146519671824952 936 3008304
SGTC_1158 4092-0494 91.8 µM -1.05312788097828 0.128339343070106 no 2922 0.146141193047885 941 1148199
SGTC_2055 5235184 200 µM -1.05315558626811 0.128333143349103 no 2923 0.14613484510329 932 2836034
SGTC_166 k072-0058 166.424 µM -1.05378565904575 0.128192205635698 no 2924 0.145990530360962 939 5846229
SGTC_3122 9126309 49.47 µM -1.05401611693443 0.128140682564039 no 2925 0.145937769160736 968 17591206
SGTC_178 4092-0806 87.505 µM -1.05414037357895 0.128112908689711 no 2926 0.145909327069496 914 2169044
SGTC_190 3970-0790 3.722 µM -1.05563004716894 0.127780262031033 no 2927 0.145568633864061 932 2832352
SGTC_1912 st060209 90.8 µM -1.05926922112475 0.126970154251708 no 2928 0.144738594050903 952 688787
SGTC_14 0354-0009 295 µM -1.05968624813976 0.126877549675552 no 2929 0.144643680552232 949 1713507
SGTC_2730 imipramine 71.33 µM -1.06694309710017 0.125273626082104 no 2930 0.142998766040908 930 3696 A tricyclic antidepressant.
SGTC_3053 9095903 49.47 µM -1.06722639652594 0.125211299074199 no 2931 0.142934807765839 986 17174018
SGTC_2126 5251174 33.877 µM -1.06797076811681 0.125047637543099 no 2932 0.1427668490074 950 790722
SGTC_2412 st077135 33.4 µM -1.07126264960391 0.124325658526728 no 2933 0.142025674469867 970 13258915
SGTC_187 1488-2104 32.728 µM -1.07237870854151 0.124081546312781 no 2934 0.141774983585572 942 2852859
SGTC_600 1495-0418 41.6 µM -1.07376650786288 0.123778465198069 no 2935 0.141463672210546 959 5377768
SGTC_2572 astragaloside iv 100 µM -1.07469602057087 0.123575759204565 no 2936 0.141255422988211 938 45006101 An anti-inflammatory agent.
SGTC_477 mead ethanolamide 10 µM -1.08074291715458 0.122262741238213 no 2937 0.139905743342127 957 16061185
SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.08127177713914 0.122148372516491 no 2938 0.139788118913088 913 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1180 1193-0155 285 µM -1.08160903395721 0.122075478212763 no 2939 0.13971314430452 972 2921347
SGTC_2727 riluzole 51.77 µM -1.08586446667028 0.121158337609226 no 2940 0.13876947984504 958 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2450 5739737 12.93 µM -1.08868409738276 0.120553320306653 no 2941 0.138146608463501 936 2262825
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.09010139807149 0.120250010247305 no 2942 0.137834240263208 928 5379071
SGTC_318 1488-0629 67.2 µM -1.09222056118367 0.119797501416936 no 2943 0.137368083540663 969 3662576
SGTC_2127 5253358 187.912 µM -1.09268136327198 0.119699264624615 no 2944 0.137266862610288 949 20612
SGTC_1308 1187-1617 41.4 µM -1.09551158917878 0.119097144597891 no 2945 0.136646285544708 949 2882570
SGTC_573 3702-0553 84.7 µM -1.09713559886401 0.118752609676877 no 2946 0.136291060235459 945 1222756
SGTC_1004 4084-0029 199 µM -1.10338263800136 0.117433860842401 no 2947 0.13493051659049 947 716894 YLR208W SEC13
SGTC_530 4358-1714 28 µM -1.10565550474358 0.116956641512858 no 2948 0.13443782789742 928 1564641
SGTC_2038 4100038 30.985 µM -1.1058293183817 0.116920203624346 no 2949 0.134400201268839 926 3596803
SGTC_2355 9061122 103.12 µM -1.10673617275751 0.116730223271566 no 2950 0.134204005574971 981 5302957
SGTC_1697 st025554 27.742 µM -1.11235225829677 0.11555856227186 no 2951 0.132993361531496 956 1269519
SGTC_1201 1889-3372 45.9 µM -1.11351810069004 0.115316388269822 no 2952 0.132742989406161 952 5392199
SGTC_750 4073-0104 132 µM -1.113924565733 0.115232040399001 no 2953 0.132655774802109 901 22330957
SGTC_3097 9117246 49.47 µM -1.11434715067602 0.115144393908115 no 2954 0.132565143233796 944 16423892
SGTC_529 4076-0302 30.3 µM -1.11744506405492 0.114503316447228 no 2955 0.131902038091091 963 5816522
SGTC_118 0083-0097 135.343 µM -1.11915976306383 0.11414957350733 no 2956 0.131535993853953 984 5207356
SGTC_351 caspofungin 25 nM -1.12090417185591 0.113790500866142 no 2957 0.13116432745641 944 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_3244 9134489 49.47 µM -1.12299020712483 0.113362164977938 no 2958 0.130720826788137 973 16584271
SGTC_2970 9090938 41.86 µM -1.12308505682766 0.113342716392473 no 2959 0.130700685974836 963 17217104
SGTC_480 am 92016 50 µM -1.12573201367082 0.112800927211404 no 2960 0.130139484394108 982 2129 K+ channel blocker.
SGTC_1737 st035557 69.7 µM -1.12641814310138 0.112660789895064 no 2961 0.129994285394126 941 5716916
SGTC_1017 4239-0030 168 µM -1.12787276775083 0.112364103908128 no 2962 0.129686828091229 933 1149593
SGTC_970 1315-0089 19.5 µM -1.12846855388894 0.112242748354371 no 2963 0.129561045025212 947 6811083 YLR033W RSC58
SGTC_2237 6667747 47.222 µM -1.12853542535045 0.112229133169385 no 2964 0.12954693232116 979 729940 YDL015C TSC13
SGTC_10 0279-0212 42.575 µM -1.13021698657556 0.111887151342379 no 2965 0.129192401908183 976 39851 YBR002C RER2
SGTC_1943 st076331 65.2 µM -1.13077666472368 0.111773494153323 no 2966 0.12907455200392 961 24208415
SGTC_38 0929-0051 58.268 µM -1.13192050549434 0.111541464473731 no 2967 0.128833928461555 961 1379719
SGTC_957 1187-1561 14.1 µM -1.13841389651055 0.110230801931277 no 2968 0.1274738470225 951 1538454
SGTC_2822 7994718 71.43 µM -1.13856552776445 0.110200328370163 no 2969 0.127442206657874 993 1018011
SGTC_26 0302-0163 425.158 µM -1.14395323407771 0.109121471927726 no 2970 0.126321516066355 992 3100915
SGTC_2194 5927483 104.545 µM -1.14608004060597 0.108697687737771 no 2971 0.125881017660391 947 760979
SGTC_1835 st008666 49.2 µM -1.14636763375595 0.108640473341406 no 2972 0.125821534471491 943 690455
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.14817757979632 0.108280895873816 no 2973 0.125447631397008 979 4174840
SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.14979017696334 0.107961247438614 no 2974 0.125115151023745 970 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1763 st044482 94.5 µM -1.15647713025813 0.106643013113207 no 2975 0.123743024383918 963 88505
SGTC_2896 9052656 71.43 µM -1.15650213677557 0.106638105347961 no 2976 0.123737913032581 939 6469436
SGTC_2255 7941087 197.44 µM -1.1622394809488 0.105516402917928 no 2977 0.122569100833996 995 935561
SGTC_512 prima-1 270 µM -1.16463437403051 0.105050712856816 no 2978 0.122083511790959 965 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2298 7976326 193.81 µM -1.1677645210593 0.104444296982632 no 2979 0.121450881435769 969 2235818
SGTC_2597 laccaic acid a 100 µM -1.1693882445342 0.104130727526807 no 2980 0.121123621960731 987 5491415 A textile dye.
SGTC_1252 0493-0875 34.8 µM -1.16953194526686 0.104103009306145 no 2981 0.121094689160664 954 3960963
SGTC_2706 st078239 82.5 µM -1.16953495402557 0.104102429008328 no 2982 0.121094083427172 970 15434492
SGTC_654 1124-0271 80.9 µM -1.16973721184637 0.104063425019274 no 2983 0.121053369085389 974 5403748
SGTC_487 nimodipine 119 µM -1.17064425204603 0.103888639041044 no 2984 0.120870901037875 977 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1934 st074720 32.6 µM -1.17494409357581 0.103062959571027 no 2985 0.120008541640917 954 17250992
SGTC_330 1488-0319 80.1 µM -1.17610069687932 0.102841677864786 no 2986 0.119777319744688 952 6846614
SGTC_1978 st071761 42 µM -1.17916359690358 0.102257350890982 no 2987 0.119166519271656 953 5147680
SGTC_1440 4100-1550 40 µM -1.1795958407501 0.102175084088218 no 2988 0.119080498990332 980 742806
SGTC_1082 camptothecin 424.86 nM -1.1860289903352 0.100956381074276 no 2989 0.117805425527761 938 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1874 staurosporine 7.6 µM -1.18795445306859 0.100593688128425 no 2990 0.11742567730741 960 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1220 1838-0075 193 µM -1.18846626433199 0.100497440064015 no 2991 0.117324881629794 941 5529645
SGTC_442 cape 100 µM -1.18867317275708 0.100458549221336 no 2992 0.117284150657864 978 5281787
SGTC_2544 sphondin 68.51 µM -1.18907440880812 0.100383163540555 no 2993 0.117205193852575 950 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_3263 9137018 49.47 µM -1.189636143414 0.100277692177681 no 2994 0.117094716782071 957 43844957
SGTC_1065 prochlorperazine maleate 2.48 µM -1.19091325733642 0.100038202132403 no 2995 0.116843819749297 984 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2818 7996756 12.99 µM -1.19187718812207 0.0998577183407456 no 2996 0.116654702027544 994 2241621
SGTC_2930 9013230 14.89 µM -1.19330183106809 0.0995914077435642 no 2997 0.116375592819918 932 2995857
SGTC_456 gingerol 170 µM -1.19556654331722 0.0991691306567191 no 2998 0.115932877018792 977 442793 A herb.
SGTC_1436 4092-1007 8.32 µM -1.19979176983876 0.0983848000987109 no 2999 0.115110110667299 945 2881121
SGTC_784 4579-0127 173 µM -1.19990971663924 0.098362970946625 no 3000 0.115087202941071 972 1948547
SGTC_2811 7967822 32.47 µM -1.19996265990392 0.0983531735589608 no 3001 0.11507692131011 964 2232244
SGTC_1836 st055642 81 µM -1.20010804643916 0.0983262728069937 no 3002 0.115048690470076 967 8571
SGTC_2360 9040895 200 µM -1.20280176365251 0.0978288309525299 no 3003 0.114526521079193 972 4914414
SGTC_2734 clemastine 41.6 µM -1.20713663959596 0.0970321974808342 no 3004 0.113689763244238 1026 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_72 0744-0168 198.391 µM -1.20715681311676 0.0970285012957184 no 3005 0.1136858793794 994 677577
SGTC_43 0570-0105 72.5 µM -1.20847110794654 0.0967879193227525 no 3006 0.11343305129035 971 1114046 YDL195W SEC31
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.21084314011527 0.0963548275215009 no 3007 0.1129777639584 1010 688801
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.21474120938819 0.0956462039492642 no 3008 0.112232404954566 985 676296 Flavone; oxidizing agent.
SGTC_2951 9072950 58.06 µM -1.21486304932567 0.0956241168351845 no 3009 0.112209164428782 963 16488155
SGTC_2083 5306046 65.942 µM -1.21505346407764 0.0955896060119309 no 3010 0.112172850394608 962 539837
SGTC_3325 9138760 55.175 µM -1.21650386394332 0.0953270358791349 no 3011 0.111896520009974 956 43844959
SGTC_747 3448-8087 38.7 µM -1.2192092370385 0.0948386938754135 no 3012 0.111382393463199 1001 5168703
SGTC_1613 st002381 52.1 µM -1.22025844177616 0.0946498007279188 no 3013 0.11118345929973 966 551167
SGTC_2733 amorolfine 100 µM -1.2218742923768 0.094359434349447 no 3014 0.110877584224253 1031 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1605 st000082 49.1 µM -1.22299000011158 0.0941593267679882 no 3015 0.1106667366367 946 1114022
SGTC_2699 st077704 54.6 µM -1.22353569527 0.0940615677820372 no 3016 0.110563715314588 979 645852
SGTC_2445 5742597 35.57 µM -1.22364250615874 0.0940424418285819 no 3017 0.110543558625477 975 1774255
SGTC_1812 st052057 4.327 µM -1.22452743382301 0.0938840937623445 no 3018 0.110376661871334 986 3645418
SGTC_1505 k297-0037 20.6 µM -1.22476985776821 0.0938407490239498 no 3019 0.11033097242451 970 4089396
SGTC_708 3448-5400 146 µM -1.22885861847974 0.0931119138554138 no 3020 0.109562409507288 988 3462195
SGTC_1739 st037196 92.5 µM -1.2296737453285 0.092967116285256 no 3021 0.109409651112881 970 612214
SGTC_738 1315-0003 72.4 µM -1.23209344124274 0.09253826670221 no 3022 0.108957090575562 991 6251474
SGTC_1724 st037281 8.293 µM -1.23333636668893 0.0923185492715017 no 3023 0.108725147589023 949 574124 YDL195W SEC31
SGTC_2062 5245942 200 µM -1.23457694699359 0.0920996316370392 no 3024 0.108493996509284 1002 1376160
SGTC_3171 9103192 49.47 µM -1.23488210147967 0.0920458418319306 no 3025 0.108437192828284 997 13018434
SGTC_1045 1348-1485 165 µM -1.23537372342887 0.0919592322003615 no 3026 0.108345723745949 981 6810614
SGTC_2452 5863136 48.41 µM -1.23796648286839 0.0915034608863416 no 3027 0.107864244488514 976 2184096
SGTC_1195 1502-0147 41.1 µM -1.2389679221677 0.0913278706016172 no 3028 0.107678688896094 966 817940
SGTC_474 dl-dihydrosphingosine 5 µM -1.24203477778675 0.0907916885019809 no 3029 0.10711186539728 956 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_844 0330-0132 15.3 µM -1.24404934651557 0.0904407523845148 no 3030 0.106740700958377 975 2828079
SGTC_645 0845-0943 5.41 µM -1.24458528875605 0.0903475615480201 no 3031 0.106642115371338 971 1885106
SGTC_2775 cyproheptadine 69.59 µM -1.2453437247947 0.0902158048795541 no 3032 0.106502714794331 973 2913 A selective serotonin reuptake inhibitor.
SGTC_2455 5377712 9.75 µM -1.25167003945563 0.0891223437320916 no 3033 0.105345060791672 960 2243908
SGTC_1030 k029-0042 36.7 µM -1.25609576614393 0.0883632707190162 no 3034 0.104540625496853 975 6080581
SGTC_856 0433-0016 11.3 µM -1.25848255597058 0.0879559083904213 no 3035 0.104108645985066 990 3911780
SGTC_1133 3473-0247 50 µM -1.25864388115096 0.0879284250310074 no 3036 0.104079494878832 953 711311
SGTC_826 1683-5028 118 µM -1.2588739417844 0.0878892429783329 no 3037 0.104037933665218 978 722377
SGTC_2391 6285546 200 µM -1.26016505925967 0.0876695919423139 no 3038 0.103804912286456 985 846083
SGTC_2128 5255449 168.493 µM -1.26373955552979 0.0870636184872046 no 3039 0.103161761300904 963 736008
SGTC_2834 9001755 58.44 µM -1.26419381176883 0.0869868343956066 no 3040 0.103080235705477 983 2989575
SGTC_2056 5235370 200 µM -1.26462804957544 0.0869134813705876 no 3041 0.103002346583972 994 5511916
SGTC_1911 st060208 74.3 µM -1.26619309447586 0.0866494917013331 no 3042 0.102721979610895 999 688783
SGTC_188 3229-0966 278.469 µM -1.26876500673659 0.0862169673720866 no 3043 0.10226244464537 973 5722370
SGTC_2111 5486399 200 µM -1.26998066457978 0.0860130903539841 no 3044 0.102045758829673 956 689674
SGTC_3112 9123419 49.47 µM -1.27150613391297 0.0857577657076291 no 3045 0.101774323331812 1007 17015854
SGTC_3355 9151058 44.0485 µM -1.27411669636871 0.0853221410526477 no 3046 0.101311031032459 990 17015728
SGTC_2996 9066192 71.4286 µM -1.27428327044554 0.0852944011957952 no 3047 0.101281521634572 979 6472854
SGTC_196 k015-0023 18.111 µM -1.27559893228532 0.0850755392431476 no 3048 0.101048665870366 973 5211998
SGTC_2447 5741742 33.78 µM -1.27596854841506 0.0850141289444391 no 3049 0.100983318684661 987 1776504
SGTC_2916 7875993 68.79 µM -1.27597118016416 0.0850136918086056 no 3050 0.100982853508637 967 1299250
SGTC_1848 st056003 16.4 µM -1.27668163915593 0.0848957455540097 no 3051 0.100857333126045 963 146492
SGTC_1926 methyl fluorone black 53.6 µM -1.27669564843356 0.0848934210494954 no 3052 0.100854859180362 918 72721 Reacts with homocysteine.
SGTC_1818 st052136 56.3 µM -1.27724903811212 0.0848016374348026 no 3053 0.100757169619121 942 674169
SGTC_152 4469-0003 551.229 µM -1.27870310655571 0.084560824470584 no 3054 0.100500812663423 979 697280
SGTC_1865 st057639 52.2 µM -1.28120576669172 0.0841475526537147 no 3055 0.100060700569665 993 688818
SGTC_1274 0865-0114 173 µM -1.28367982756757 0.0837404956308879 no 3056 0.099627002748868 999 870624
SGTC_1123 mangostin 811.285 nM -1.28404947402399 0.083679804958369 no 3057 0.0995623226039431 946 5281650 An antioxidant.
SGTC_2101 5377231 179.231 µM -1.29334028298275 0.0821652191200421 no 3058 0.0979466970432908 1001 2844213
SGTC_681 1642-0006 26.6 µM -1.29408468844506 0.0820447656658465 no 3059 0.0978180848854758 1023 4446530
SGTC_148 3253-0744 288.01 µM -1.29520046666476 0.0818644690059323 no 3060 0.0976255419451687 967 6893655
SGTC_3337 9144342 33.5465 µM -1.29726850209287 0.0815310886197234 no 3061 0.0972694090237893 984 17682949
SGTC_2389 9091542 195.52 µM -1.30121874300407 0.0808971318432212 no 3062 0.0965917957280273 973 3626624 YOL127W RPL25
SGTC_1833 st055984 71 µM -1.30460339167129 0.08035691076833 no 3063 0.0960139663889515 993 676288
SGTC_431 k089-0097 107 µM -1.30625947789169 0.0800935794128439 no 3064 0.0957321661828454 943 5499420
SGTC_722 3534-0461 190 µM -1.31430239180731 0.0788239601179163 no 3065 0.094372231352631 979 658262
SGTC_3330 9141424 71.43 µM -1.31459403191724 0.0787782112234749 no 3066 0.094323188475429 988 27261020
SGTC_2112 5488546 200 µM -1.31657203603796 0.0784684572043606 no 3067 0.0939910586869297 1018 600757
SGTC_500 h-89 112 µM -1.31831094616086 0.0781969085739613 no 3068 0.0936997890725697 1002 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_609 0986-0026 86.3 µM -1.32214670462045 0.0776004364988148 no 3069 0.0930596520098817 972 2848610
SGTC_3078 9116413 49.47 µM -1.32300516575806 0.0774674174955188 no 3070 0.0929168299742479 984 17177322
SGTC_711 k292-0785 179 µM -1.3259148330021 0.0770178509871434 no 3071 0.0924339546017691 980 4146315
SGTC_1409 3909-8004 61.9 µM -1.32620956009389 0.0769724241568621 no 3072 0.0923851467688515 1001 2119279
SGTC_1629 st005085 44.9 µM -1.32856346700401 0.0766103427248587 no 3073 0.0919960158239859 964 24207091
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.33040742318658 0.076327608673736 no 3074 0.0916920350539814 1000 16486 A toxic proline analog.
SGTC_2936 9038235 15.59 µM -1.33096417392063 0.0762423982574401 no 3075 0.0916003997369838 973 4749415
SGTC_2821 7996764 71.43 µM -1.33149976985793 0.0761604939134024 no 3076 0.0915123103356523 965 2987135
SGTC_464 bw-b 70c 158 µM -1.33552255446703 0.075547461242124 no 3077 0.0908526892137945 1005 5353454
SGTC_1849 st056239 19.2 µM -1.33839401929544 0.075112183236757 no 3078 0.0903840137384924 988 5393181
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.33970569122651 0.0749139876994679 no 3079 0.0901705232776216 1008 16623 A steroid.
SGTC_1947 st076332 61.6 µM -1.34192004658839 0.0745803009456375 no 3080 0.0898109605447841 998 24208416
SGTC_421 streptovitacin 30 mM -1.34480675285866 0.0741470008848593 no 3081 0.0893438244836958 1011 91467 include heat shock
SGTC_3240 9133527 49.47 µM -1.35173206120962 0.0731153413093907 no 3082 0.0882305223632428 1000 17617455
SGTC_3072 9116419 49.47 µM -1.356494347563 0.0724123044407245 no 3083 0.0874709663058133 998 17170162
SGTC_2064 5220758 200 µM -1.35838957279126 0.0721339651858173 no 3084 0.0871700505875716 993 788518
SGTC_175 3793-3120 23.7 µM -1.36132955553441 0.0717038130930576 no 3085 0.0867047834425005 1006 5322297
SGTC_2931 9014674 55.67 µM -1.36134337028662 0.071701796496547 no 3086 0.0867026015775202 1015 2996810
SGTC_1623 st003709 20.3 µM -1.3625076995519 0.0715319908444315 no 3087 0.0865188579612708 992 16192618
SGTC_2377 9073351 62.6 µM -1.36401276599544 0.0713129495714946 no 3088 0.0862817739298066 1011 7337946 YHR072W ERG7
SGTC_410 α-linolenic acid 100 µM -1.36680237342861 0.0709083234449766 no 3089 0.0858436293304992 1008 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_605 1315-0399 119 µM -1.36696942739943 0.0708841487348607 no 3090 0.0858174442481097 1005 24020461
SGTC_1388 3346-4487 254 µM -1.36918056598928 0.0705647667235097 no 3091 0.0854714196356045 1023 3345614
SGTC_3301 9125354 19.7965 µM -1.37035855440224 0.0703950675407965 no 3092 0.0852875015040466 984 41905162
SGTC_2852 9023854 51.95 µM -1.37095584477998 0.0703091427863863 no 3093 0.0851943605211413 1007 19798528
SGTC_3145 9085516 49.47 µM -1.37436190382898 0.0698206958388623 no 3094 0.0846646784824993 1021 25236195
SGTC_712 r015-0009 80.6 µM -1.3801139171286 0.069001761387272 no 3095 0.0837757864466839 1013 6813872 YLR060W FRS1
SGTC_1614 st002383 48.6 µM -1.38259532357916 0.0686507688891597 no 3096 0.0833944918859264 990 1947235
SGTC_1864 st057645 30.4 µM -1.38272423045246 0.0686325728316856 no 3097 0.0833747196709295 1005 688666
SGTC_1776 st049249 45.9 µM -1.38339828415323 0.0685374862662579 no 3098 0.0832713881937545 1014 1822314
SGTC_1057 3448-5381 134 µM -1.38742467522098 0.0679716114270069 no 3099 0.0826561525587137 953 5497911
SGTC_419 nsc-638432 893 µM -1.3885599483793 0.0678127122567531 no 3100 0.0824833017652505 1003 368090
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.39021873589085 0.0675810551470071 no 3101 0.0822312328807924 966 279621
SGTC_2569 tetrandrine 100 µM -1.39356170957027 0.0671160523022335 no 3102 0.0817249990289827 996 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1752 st044819 83.042 µM -1.39691177007782 0.0666525496447344 no 3103 0.0812200523608595 1001 441209 YML126C ERG13
SGTC_312 4092-0653 6.84 µM -1.39847308862411 0.0664373791789946 no 3104 0.0809855242479114 979 1148278
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.3991350749787 0.0663463111649367 no 3105 0.0808862406879599 986 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2907 7721985 69.9 µM -1.40001110282713 0.0662259465636721 no 3106 0.0807549968485241 1018 3267881
SGTC_1120 ficusin 1.78878 µM -1.40027677990993 0.0661894764687316 no 3107 0.0807152257079433 1011 6199 A DNA cross-linker.
SGTC_1156 4092-0367 4.88 µM -1.40094130215583 0.0660983241114898 no 3108 0.0806158132937812 995 1357585
SGTC_575 k072-0246 11.9 µM -1.40331583994012 0.0657734037642271 no 3109 0.0802613384045115 1017 6796779
SGTC_1073 triclabendazole 3.09 µM -1.40587347082321 0.0654248162232983 no 3110 0.0798808501410806 1019 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_671 0560-0003 407 µM -1.4065243212853 0.0653363388889752 no 3111 0.0797842438632205 1014 3238678
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.40706450932531 0.0652629756382985 no 3112 0.0797041304323409 1008 5355888
SGTC_3050 9093513 49.47 µM -1.4075464140975 0.0651975818253878 no 3113 0.0796327121657336 976 25236664
SGTC_753 1322-0200 289 µM -1.40792850186592 0.0651457691878394 no 3114 0.0795761211952761 1017 5403907
SGTC_1481 3346-2004 36 µM -1.41207400516903 0.0645856742240839 no 3115 0.0789640859377343 1029 2770522
SGTC_1216 1165-0504 9.65 µM -1.41496628763681 0.0641971210539884 no 3116 0.0785391903498576 1027 6304004
SGTC_2451 5856223 45.7 µM -1.415993862971 0.0640595134649665 no 3117 0.0783886506477501 1004 2179896
SGTC_2043 5101342 149 µM -1.41817315025974 0.0637684335676074 no 3118 0.0780701093899396 1022 678451
SGTC_65 0798-0905 34.986 µM -1.42192854551851 0.0632692536905655 no 3119 0.077523497689294 1030 3602145
SGTC_633 0437-0093 97.7 µM -1.42715305829564 0.0625798605910863 no 3120 0.0767678908301073 1015 2831118
SGTC_3093 9117344 49.47 µM -1.43463775787755 0.0616024484521233 no 3121 0.0756951746067353 996 24824913
SGTC_1097 itavastatin 7.23 µM -1.43525828951283 0.061521952586957 no 3122 0.0756067544328207 1003 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_721 1187-1332 279 µM -1.43573663170123 0.0614599577394025 no 3123 0.0755386487029362 1027 25730
SGTC_2923 7992654 58.14 µM -1.4359516992535 0.0614321001264367 no 3124 0.0755080429067021 994 2985126
SGTC_2502 avocadyne acetate 18.59 µM -1.43605608810003 0.0614185822373541 no 3125 0.0754931909635046 994 3952079
SGTC_576 1073-0113 22.7 µM -1.43635426082914 0.0613799829984306 no 3126 0.0754507806419459 1026 5439563
SGTC_1419 3993-2473 62.6 µM -1.43650348276143 0.0613606729456154 no 3127 0.0754295630172021 1029 704026
SGTC_316 k060-0003 58.6 µM -1.43939938256352 0.0609868682236111 no 3128 0.0750186996034137 1028 6152314
SGTC_990 3985-0011 41.3 µM -1.44497925150601 0.060271636844417 no 3129 0.0742318568505003 1004 5399565 YGL099W LSG1
SGTC_1310 1188-0297 994 nM -1.44757428400114 0.0599412484521769 no 3130 0.0738680737375965 980 1588352
SGTC_320 4092-0846 5.34 µM -1.44974103863676 0.0596664746011346 no 3131 0.0735653735186615 1011 1359356
SGTC_1089 terbinafine 2.25 µM -1.45390790670719 0.0591408342874233 no 3132 0.072985920209367 1003 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1132 3456-3614 2.5 µM -1.4628720450386 0.0580223449786382 no 3133 0.0717511973165056 1015 3125502
SGTC_1931 st074438 57.1 µM -1.46439227390919 0.0578343198053763 no 3134 0.0715433989530778 1026 2787313
SGTC_2192 5915882 198.485 µM -1.46475915397092 0.0577890151174004 no 3135 0.0714933197682309 1013 2876149
SGTC_1319 1306-0155 43.7 µM -1.46532778150478 0.0577188525079045 no 3136 0.0714157551848661 1019 3122360
SGTC_2390 9097792 176.6 µM -1.46759305272733 0.057440006786881 no 3137 0.0711073981205892 1008 4497149
SGTC_3138 9097216 49.47 µM -1.46867436650702 0.0573072756563412 no 3138 0.0709605666791589 1015 25237486
SGTC_2084 5306078 60.6385 µM -1.47386137851143 0.056673923308021 no 3139 0.0702594591391255 1026 679340
SGTC_2041 5107442 45.335 µM -1.47407347574366 0.0566481433174102 no 3140 0.0702309045891234 1023 793005
SGTC_1043 0916-0009 19.3 µM -1.47812612102243 0.0561573251065242 no 3141 0.0696870118436962 1024 3101130
SGTC_528 3492-0019 172 µM -1.48537337401238 0.0552879724595196 no 3142 0.0687224724219606 1007 2869262
SGTC_2024 5144227 134 µM -1.48969572781568 0.0547745610982509 no 3143 0.0681521292216121 1009 3475211
SGTC_1774 st048371 48.465 µM -1.491587371362 0.0545510596489866 no 3144 0.0679036754333006 1024 4242727
SGTC_314 1671-0008 2.74 µM -1.49894790355042 0.0536882537382785 no 3145 0.0669435738257769 1012 3913060
SGTC_2057 5236571 38.335 µM -1.49904091153089 0.0536774208476598 no 3146 0.066931509477845 1005 54684039 YBR257W POP4
SGTC_584 0986-0246 15.4 µM -1.5023684697241 0.0532909889232238 no 3147 0.0665009873172645 1034 53315 YDR232W HEM1
SGTC_952 1185-0122 232 µM -1.50541044971246 0.0529396538381807 no 3148 0.0661092920750547 1015 678600
SGTC_526 4469-0568 170 µM -1.51233476574052 0.0521467764416367 no 3149 0.0652243605211408 1003 2901964
SGTC_507 nimesulide 162 µM -1.51274779943676 0.0520997812185241 no 3150 0.0651718664575489 1023 4495 A COX2 inhibitor.
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.51633118943417 0.0516934716762791 no 3151 0.0647178144357564 1031 5393153
SGTC_1363 1636-0063 10.4 µM -1.5187814216078 0.0514171003736323 no 3152 0.0644087618983799 1020 6072185
SGTC_2534 helenine 20.12 µM -1.52134713237437 0.0511289646879994 no 3153 0.0640863741707067 1008 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1847 st056231 15 µM -1.52371267130327 0.0508644486374536 no 3154 0.0637902513583146 1013 5393180
SGTC_1594 piperine 70.1 µM -1.52516710507715 0.0507023545669323 no 3155 0.0636087115349443 1024 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3099 9120367 49.47 µM -1.5282109261252 0.0503644575375301 no 3156 0.0632300884413798 1039 24824940
SGTC_535 2293-4129 48.2 µM -1.53452341981138 0.049669423127692 no 3157 0.0624504680962263 1041 396118 YIL048W NEO1
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.54255015100131 0.0487967200915946 no 3158 0.0614699804304062 1041 368090
SGTC_2859 9028643 45.46 µM -1.55356380879399 0.0476192563592185 no 3159 0.0601442488563265 988 17151580
SGTC_2199 6590217 200 µM -1.56094786629479 0.0468426534830443 no 3160 0.0592680260568922 983 703109
SGTC_1339 1486-1321 22.7 µM -1.56142754112895 0.0467925581575094 no 3161 0.0592114539301814 1025 3469382
SGTC_1313 1220-0047 237 µM -1.5618351101397 0.0467500270557759 no 3162 0.0591634191397982 1019 3528706
SGTC_458 nppb 133 µM -1.56259127168867 0.0466712013802815 no 3163 0.0590743812936778 1035 4549 A chloride channel blocker.
SGTC_2826 7992541 19.48 µM -1.56325555556145 0.0466020414712114 no 3164 0.0589962487804894 1043 2985066
SGTC_2911 7942208 15.64 µM -1.563782538148 0.0465472347911702 no 3165 0.0589343232164368 1000 1243384
SGTC_1104 tacrolimus 29.8 µM -1.56470017274666 0.0464519234105571 no 3166 0.0588266139866834 1005 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_982 1491-0518 27.5 µM -1.56566335483288 0.0463520497550117 no 3167 0.0587137247623589 1030 3091256
SGTC_2172 5754775 163.918 µM -1.5703214761939 0.0458714733346862 no 3168 0.0581701701510159 1016 2263357
SGTC_2288 7946289 167.31 µM -1.57314325731302 0.0455823041012647 no 3169 0.0578428253000439 1045 1246052
SGTC_1612 st002233 45.4 µM -1.57346668168499 0.045549254188817 no 3170 0.0578053986688243 1016 1035021
SGTC_197 4544-0043 41.561 µM -1.57731768886073 0.0451572083130483 no 3171 0.0573612221222039 1035 896523
SGTC_1247 0448-0043 5.84 µM -1.58102826715317 0.0447820315334734 no 3172 0.056935787326812 1036 3089013 YGL099W LSG1
SGTC_814 3342-0569 96 µM -1.58145717027097 0.0447388274147602 no 3173 0.0568867722337988 1031 4346283
SGTC_1304 1165-0502 251 µM -1.58530928171304 0.0443523006298016 no 3174 0.056448040613917 1031 767425
SGTC_1547 harmine 94.2 µM -1.58597162278192 0.0442861122531151 no 3175 0.0563728734635254 1007 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2533 agelasine 13.65 µM -1.58835821556274 0.0440482777337492 no 3176 0.0561026801712885 1009 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2784 7567673 72.73 µM -1.59197700172799 0.0436896155733966 no 3177 0.0556949360906658 1008 3471247
SGTC_977 1348-1378 135 µM -1.59383044553279 0.0435068331814153 no 3178 0.0554870082178663 1018 X977
SGTC_2417 cerulenin 830 nM -1.59575493137139 0.0433176984787629 no 3179 0.0552717595489045 1029 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_3281 9140613 49.47 µM -1.59749492943954 0.0431472668842058 no 3180 0.0550777135264677 1008 16013766
SGTC_729 4092-0585 94.1 µM -1.61094711282194 0.0418478427112262 no 3181 0.0535956250661669 1015 2169061
SGTC_1394 3474-0001 65.7 µM -1.62251463514677 0.0407559744716131 no 3182 0.0523466010284099 1036 5017666 YIL048W NEO1
SGTC_2473 5854593 8.94 µM -1.62691951411884 0.0403463199026012 no 3183 0.0518770964412122 1034 2872951
SGTC_3117 9124945 49.47 µM -1.62734254724264 0.0403071543567612 no 3184 0.0518321831276604 1021 17592065
SGTC_1361 1608-0041 5.61 µM -1.62789825254682 0.040255752590527 no 3185 0.0517732310111266 1039 X1361
SGTC_3082 9117008 49.47 µM -1.63146420339834 0.0399271741055977 no 3186 0.0513962035946604 1035 41448529
SGTC_287 k060-0039 29.6 µM -1.63227281609251 0.039852969857622 no 3187 0.0513110135865226 1036 5861974
SGTC_1504 k297-0033 30 µM -1.63313527433354 0.0397739479322946 no 3188 0.0512202746095111 998 4388117
SGTC_2345 9052315 157.45 µM -1.63621479940012 0.0394928282272253 no 3189 0.0508973200746478 1028 6469265
SGTC_47 0149-0135 24.25 µM -1.64877461877338 0.038362976948137 no 3190 0.0495969082907532 1043 5239155
SGTC_1732 st034308 51.822 µM -1.65360414307328 0.0379355997773648 no 3191 0.049103985174075 1018 830119
SGTC_2797 7859098 81.82 µM -1.66045611549027 0.0373359243296444 no 3192 0.0484113646318619 1020 972681
SGTC_2521 angolensin 13.4 µM -1.66427209993953 0.0370053258759073 no 3193 0.0480290326548925 1038 821428 A flavenoid.
SGTC_1075 aripiprazole 15.2 µM -1.66488847600968 0.0369521511808215 no 3194 0.0479675038764197 1049 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1998 st075797 76.8 µM -1.66581014797118 0.0368727551955324 no 3195 0.0478756171361877 1032 24208315
SGTC_793 0488-0545 106 µM -1.66730536342123 0.0367442489347882 no 3196 0.0477268503561533 1043 292548
SGTC_549 1661-1316 519 µM -1.68519848282348 0.0352346580075002 no 3197 0.0459751418470312 1046 2857282
SGTC_2850 9015429 58.44 µM -1.68971502419868 0.0348617607344195 no 3198 0.0455412437586741 1035 6457570
SGTC_2161 5662504 8.5105 µM -1.69899477171236 0.0341057651494019 no 3199 0.0446600843614578 1008 2859334
SGTC_2304 7443016 91.4 µM -1.70144369973902 0.0339085213925001 no 3200 0.0444298506609655 1042 939854
SGTC_2203 7227154 166.4 µM -1.70333603732664 0.0337567505048055 no 3201 0.0442526001088267 1049 896304
SGTC_1734 st037168 69.4 µM -1.70708457663023 0.0334577570557678 no 3202 0.0439031666994999 1041 708907
SGTC_1993 st073995 70.8 µM -1.70840656312717 0.0333528333459104 no 3203 0.0437804651540653 1046 3098394
SGTC_2937 9044753 11.33 µM -1.71960208773323 0.0324750851136285 no 3204 0.0427523982128811 1020 6465530 YGL099W LSG1
SGTC_2140 5586273 200 µM -1.72061997376124 0.0323962350368502 no 3205 0.0426599032852692 1051 854421
SGTC_2808 7946468 45.46 µM -1.72190862323032 0.0322966370435746 no 3206 0.0425430363203705 1037 2970879
SGTC_2346 9031566 143.75 µM -1.72446122937982 0.0321000955263104 no 3207 0.0423123061366488 1046 4771086
SGTC_748 act1.228 77.9 µM -1.7315251061104 0.0315613443592267 no 3208 0.0416790755107776 1039 4421505 YNR035C ARC35
SGTC_2489 cantharidin 73.42 µM -1.73417229356235 0.0313613821685604 no 3209 0.0414437586946855 1036 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2924 9010168 62.78 µM -1.74353588591125 0.0306624676032141 no 3210 0.0406200257505003 1055 2993929
SGTC_282 k297-0036 65.7 µM -1.75540294962701 0.0297952709353158 no 3211 0.03959520395024 1043 5061378
SGTC_1067 clotrimazole 1.36 µM -1.76197661941082 0.0293237161946048 no 3212 0.0390366239337751 1036 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1307 1187-1599 12.2 µM -1.7632203579156 0.0292351989360568 no 3213 0.0389316657592957 1048 1538471
SGTC_3090 9117696 49.47 µM -1.76699593123903 0.0289678486967241 no 3214 0.0386144548548847 1039 7923821
SGTC_176 1486-1328 72.834 µM -1.76742614773378 0.0289375142157221 no 3215 0.0385784435608558 1034 22310231
SGTC_2842 9000675 19.48 µM -1.77029988766656 0.0287355638704732 no 3216 0.0383385983922007 1036 2989072
SGTC_3255 9139072 49.47 µM -1.77634234383251 0.0283147550545662 no 3217 0.0378382539738652 1052 17646060
SGTC_2721 ifenprodil 61.44 µM -1.77748645932608 0.0282356568477912 no 3218 0.0377441183723611 1040 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1254 0550-0035 264 µM -1.78348233678334 0.0278241349015049 no 3219 0.0372539103711792 1049 15121435
SGTC_1994 st072947 40.9 µM -1.78565515375782 0.027676244326271 no 3220 0.0370775554004784 1052 5286565 YDL195W SEC31
SGTC_1260 0700-1617 7.75 µM -1.78633694083216 0.0276299744342772 no 3221 0.0370223595393939 1030 2853078
SGTC_928 2764-0428 58.7 µM -1.79130198728136 0.0272949593914055 no 3222 0.0366224237048224 1053 662578
SGTC_2418 pentamidine 31.67 µM -1.79219910745225 0.027234789346368 no 3223 0.0365505387959785 993 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1238 0333-0287 48.8 µM -1.79298804509444 0.0271819666060111 no 3224 0.0364874178323465 1048 7226
SGTC_858 0438-0351 2.77 µM -1.80464306789693 0.0264115209985126 no 3225 0.0355652770302491 1058 2799119
SGTC_2626 ethyl orsellinate 100 µM -1.80540821358657 0.0263615865876263 no 3226 0.0355054134087737 1051 75653 A natural product.
SGTC_2108 5365811 200 µM -1.80956349416139 0.0260917834573199 no 3227 0.0351817526993992 1042 780283
SGTC_398 bronopol 33.3 µM -1.81307691262504 0.0258654620136154 no 3228 0.0349099797523774 1049 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1465 k213-0056 144 µM -1.81632474906044 0.0256577117337115 no 3229 0.0346602854789038 1021 24048857 YMR208W ERG12
SGTC_2082 5219693 150 µM -1.83688674182485 0.0243746210944462 no 3230 0.0331133084669942 1056 2834649
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.84085206791922 0.024133480907673 no 3231 0.0328216200822682 1057 6312947
SGTC_2698 st077697 67.5 µM -1.86721674368918 0.0225806305295274 no 3232 0.0309356631600781 1062 3154499
SGTC_2302 7771753 200 µM -1.86745874940645 0.0225667763353287 no 3233 0.030918776099305 1037 2203047
SGTC_1447 4239-0816 81.9 µM -1.86755191533074 0.0225614447407432 no 3234 0.0309122770531536 1049 1341554
SGTC_2210 7115885 190.385 µM -1.87081406174836 0.0223754308002194 no 3235 0.0306854289332449 1073 2927039
SGTC_2841 9004761 38.96 µM -1.87893938953511 0.0219177252072961 no 3236 0.0301263848299334 1042 2991039
SGTC_520 3584-0023 682 µM -1.88208728413405 0.02174253929513 no 3237 0.0299120827868766 1048 1340790
SGTC_2144 5628481 200 µM -1.88252105154484 0.0217184923484494 no 3238 0.0298826521716369 1052 2818399
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.88451605928242 0.0216081833713802 no 3239 0.0297476023144448 1060 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_3106 9121286 49.47 µM -1.89049539718787 0.02128040278983 no 3240 0.0293458677954392 1038 15943471
SGTC_3198 9112019 49.47 µM -1.89533630689001 0.0210181189791925 no 3241 0.0290239305248817 1072 45595555
SGTC_796 1234-0020 70.7 µM -1.89650080572418 0.0209554354093364 no 3242 0.02894692677538 1043 46495034
SGTC_2420 aureobasidin a 50 nM -1.90096371311741 0.0207166656573133 no 3243 0.0286533828622652 1055 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2801 7907800 81.82 µM -1.90301793332313 0.0206075396155167 no 3244 0.0285191026202799 1038 6620925
SGTC_2250 alverine citrate 130 µM -1.90376843543022 0.0205677924302583 no 3245 0.0284701745542225 1029 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1112 tnp00069 1.16933 µM -1.90658740593607 0.020419077140803 no 3246 0.0282870186160392 1054 145826
SGTC_2079 5212404 121 µM -1.93195331729796 0.0191214217732232 no 3247 0.0266826340278551 1060 758462
SGTC_2749 bexarotene 57.39 µM -1.93464897698898 0.0189877333176055 no 3248 0.0265166927679717 1047 82146 An retinoic acid receptor inhibitor.
SGTC_1173 0443-0020 122 µM -1.93820767824938 0.0188124613344744 no 3249 0.0262989451826221 1069 5331295
SGTC_2790 5423970 71.43 µM -1.94503131958595 0.01848023421465 no 3250 0.0258856044670707 1053 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1484 3473-2379 286 µM -1.94624241145441 0.0184217941233249 no 3251 0.0258128137937611 1088 671917
SGTC_1471 k673-0312 37 µM -1.9478278278136 0.0183455293126669 no 3252 0.0257177839279122 1069 24099884
SGTC_3098 9119039 49.47 µM -1.95880843058969 0.0178246661416087 no 3253 0.0250676129537524 1051 17161528
SGTC_3305 9127027 53.8275 µM -1.96239530392169 0.0176572799372524 no 3254 0.0248582395425545 1060 41905295
SGTC_1915 st067105 30.6 µM -1.96465297353422 0.0175526121570634 no 3255 0.024727208145466 1052 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_3123 9126162 49.47 µM -1.96536816057174 0.0175195660413149 no 3256 0.0246858209161391 1047 25239884
SGTC_1909 st060837 51.5 µM -1.97885968543849 0.0169060538324512 no 3257 0.0239159031622407 1039 678937
SGTC_3071 9117417 49.47 µM -1.98102840212091 0.0168091679441878 no 3258 0.0237940442751821 1057 45595590 YGL055W OLE1
SGTC_1557 sumaresinolic acid 42.3 µM -1.98135860938009 0.0167944579060965 no 3259 0.0237755359962485 1057 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.98235049225277 0.0167503378076194 no 3260 0.0237200132441242 1052 6708514
SGTC_467 ro 31-8220 72.8 µM -1.98860903652646 0.0164742308610158 no 3261 0.0233721865974167 1053 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_789 1309-1135 70.6 µM -1.99953546008744 0.0160015273004181 no 3262 0.0227752245608549 1064 3092424
SGTC_2802 7925815 54.55 µM -2.00790028973056 0.0156475462191439 no 3263 0.022326944199579 1054 1262923
SGTC_1309 pyrazolanthrone 13.4 µM -2.01255418198355 0.0154535283681499 no 3264 0.0220807756078675 1060 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2322 7413319 38.22 µM -2.0241201823878 0.0149802714510255 no 3265 0.0214788937467669 1036 1840400
SGTC_717 1532-0246 73.2 µM -2.03158648007812 0.0146814280954246 no 3266 0.0210977682683704 1066 9561992
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -2.03209218837418 0.0146613735687669 no 3267 0.0210721620308965 1060 688667
SGTC_1712 st032288 53.4 µM -2.03663197796735 0.0144823953272653 no 3268 0.0208434678711012 1065 2883011
SGTC_1866 st057638 64 µM -2.04636186054918 0.0141051267353361 no 3269 0.0203603907877083 1050 688802
SGTC_854 0422-0053 192 µM -2.04692702874923 0.0140834754568178 no 3270 0.0203326249014581 1070 3596728
SGTC_2249 haloperidol 116.36 µM -2.05575795715446 0.0137488694641143 no 3271 0.0199029261825935 1043 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1372 2752-0194 270 µM -2.05707631048772 0.0136995097406889 no 3272 0.0198394430178547 1056 823334
SGTC_125 0133-0007 11.75 µM -2.06533946035217 0.0133936026467937 no 3273 0.0194454461858041 1062 26541
SGTC_74 000s-0487 160.283 µM -2.06540521622755 0.0133911921732678 no 3274 0.019442337720771 1050 677548
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -2.06635684706171 0.013356349286713 no 3275 0.0193973986966218 1082 75037 A free radical scavenger.
SGTC_2105 5350118 200 µM -2.0696675287317 0.0132357417352113 no 3276 0.0192417447661831 1071 2133313
SGTC_1249 0481-0015 10.2 µM -2.07497166354027 0.013044474259265 no 3277 0.0189945805342154 1056 4227577
SGTC_827 3253-0474 693 µM -2.08456774013545 0.0127045059465678 no 3278 0.0185542776666325 1071 5402065
SGTC_202 3594-0513 34.79 µM -2.09635815325996 0.0122973166494693 no 3279 0.0180252158111852 1084 708429
SGTC_391 gliotoxin 8.33 µM -2.10160130598653 0.0121199041496317 no 3280 0.0177941076856495 1072 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_551 k048-0028 34.9 µM -2.10638421564714 0.0119600043511939 no 3281 0.0175854956328796 1054 6836383
SGTC_3204 9114183 49.47 µM -2.10803486274944 0.011905247037619 no 3282 0.0175139869765765 1053 17027248
SGTC_1816 st051957 91.6 µM -2.1211468632567 0.0114779519588566 no 3283 0.0169547226403825 1081 674121
SGTC_2265 7929201 200 µM -2.13624795322869 0.011002399059423 no 3284 0.0163296043501857 1068 1265108
SGTC_2113 5491891 107.031 µM -2.15192146630141 0.0105270390481016 no 3285 0.0157017701211922 1062 789979
SGTC_934 2950-0684 338 µM -2.15599585042075 0.0104064373185456 no 3286 0.0155419945882421 1064 1121253
SGTC_1312 1218-2183 165 µM -2.15613611616416 0.0104023069860194 no 3287 0.0155365190531852 1071 6744073
SGTC_2235 salicylic acid 500 µM -2.16554589846779 0.010128465431391 no 3288 0.0151729522084664 1085 338 A COX inhibitor and kinase inhibitor.
SGTC_126 0417-1624 672.48 µM -2.17771119068636 0.0097837697675814 no 3289 0.0147137726221433 1069 41912 YDL195W SEC31
SGTC_1562 morin hydrate 59.1 µM -2.18069329299388 0.00970085417581275 no 3290 0.0146030547300417 1065 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2878 9043973 25.97 µM -2.18319244204715 0.00963184035757873 no 3291 0.0145108205589437 1075 6465167
SGTC_3148 9097893 49.47 µM -2.19287106024752 0.00936859868877954 no 3292 0.0141583351599972 1059 17174100
SGTC_1488 4013-0813 75.9 µM -2.20290299520856 0.00910241101896263 no 3293 0.0138007932391344 1073 2910057
SGTC_2803 7707263 71.43 µM -2.20818647482747 0.0089648995024413 no 3294 0.0136156384171072 1063 2199229
SGTC_818 4072-2707 53.5 µM -2.212206949102 0.00886148251638941 no 3295 0.0134761844608711 1059 882871
SGTC_205 1486-1330 71.903 µM -2.23124931773338 0.00838573941365905 no 3296 0.0128323094089898 1078 4118834
SGTC_3011 9081274 71.4286 µM -2.23471584482947 0.00830158876399758 no 3297 0.012718004857171 1076 6625322
SGTC_1240 0356-0016 42.1 µM -2.24005533076665 0.00817342235027071 no 3298 0.0125436654958612 1030 4305613
SGTC_3352 9151559 45.5865 µM -2.24059107584597 0.00816065906306758 no 3299 0.0125262876540271 1083 17159339
SGTC_3135 9127742 49.47 µM -2.25151186360322 0.00790427800374194 no 3300 0.0121765681732872 1069 3643468
SGTC_2785 7756463 72.73 µM -2.26103609848762 0.00768649396817992 no 3301 0.0118785109003322 1070 2201551
SGTC_1730 st033808 45.1 µM -2.27054884844622 0.00747426252937103 no 3302 0.0115871514977412 1063 1045166
SGTC_853 0419-0306 21 µM -2.27425781356396 0.0073929240366947 no 3303 0.0114752450116715 1084 762713
SGTC_505 gw-5074 63.9 µM -2.27941794289176 0.00728105908872439 no 3304 0.0113211163577754 1067 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_422 cantharidin 155 µM -2.28783348876715 0.00710182076760991 no 3305 0.0110736099000675 1069 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2933 9026794 32.47 µM -2.30355464714373 0.00677738855726862 no 3306 0.0106238281049328 1070 17586027
SGTC_923 1900-2434 73.3 µM -2.30375326101883 0.00677337499920738 no 3307 0.0106182490839075 1071 5910570
SGTC_926 2268-1401 59.4 µM -2.31814926859474 0.00648799754445491 no 3308 0.0102206050298983 1076 2931578
SGTC_3002 9075603 71.4286 µM -2.32611772651073 0.0063346529877484 no 3309 0.0100061355670006 1071 20105405
SGTC_413 propylparaben 100 µM -2.32678166406743 0.00632202218385559 no 3310 0.00998844439851543 1075 7175 A pharmaceutical preservative.
SGTC_396 dithiazanine 1.25 µM -2.336915591238 0.00613198180221984 no 3311 0.009721786743945 1077 10578 An antihelmenthic.
SGTC_2513 baicalein 25.65 µM -2.33694628590048 0.00613141396175313 no 3312 0.00972098860522328 1085 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_914 3820-6779 408 µM -2.33810677069414 0.00610997954924214 no 3313 0.0096908550390887 1068 2893481
SGTC_614 0462-0418 107 µM -2.353415659374 0.00583337283904068 no 3314 0.009300913630578 1063 5188303
SGTC_1992 st073643 23.3 µM -2.3570058026663 0.00577013551407253 no 3315 0.00921147948865544 1088 3161292
SGTC_3001 9076041 71.4286 µM -2.42101730919167 0.00474031766182442 no 3316 0.0077385701508766 1082 16004211
SGTC_3203 9113543 49.47 µM -2.42804509735129 0.00463789479474795 no 3317 0.00759022776283074 1072 17018012
SGTC_2713 st079149 53.4 µM -2.43639253864625 0.00451880844733421 no 3318 0.0074172882514143 1080 3103253
SGTC_361 000s-0510 1.45 µM -2.44221634040522 0.00443734946309452 no 3319 0.00729869804118787 1071 660
SGTC_1128 3448-9350 235 µM -2.4551142805304 0.00426159502221315 no 3320 0.00704199033902337 1070 619386
SGTC_501 nsc-95397 161 µM -2.48189155589218 0.0039164529511293 no 3321 0.00653435204548206 1076 262093
SGTC_2193 5925765 200 µM -2.4862897576227 0.00386222160781644 no 3322 0.00645414081967944 1081 877370
SGTC_1342 1486-1464 234 µM -2.49807299721829 0.00372023168537232 no 3323 0.00624352388008345 1083 3253938
SGTC_2873 9040596 71.43 µM -2.51765906832327 0.00349454893863253 no 3324 0.00590688057620373 1083 6463863
SGTC_1213 1315-0166 115 µM -2.53945869117315 0.00325788322486176 no 3325 0.00555120777712708 1080 768401
SGTC_2862 9027634 71.43 µM -2.54266727973106 0.00322429400649002 no 3326 0.00550049643087807 1073 5012562
SGTC_1932 st074806 40.9 µM -2.55012097321139 0.00314746429116023 no 3327 0.00538427728517439 1074 17251235
SGTC_3196 9111891 49.47 µM -2.57480955849926 0.00290461165804888 no 3328 0.00501476463137328 1084 18891510
SGTC_577 r071-0003 38.6 µM -2.57974098547393 0.00285817711334909 no 3329 0.00494372222705567 1087 4568517 YMR134W ERG29
SGTC_1478 0453-0656 35.7 µM -2.58148073265001 0.00284195601475361 no 3330 0.00491887413283867 1088 5258496
SGTC_428 3448-4153 16.5 µM -2.58311107417598 0.0028268304115752 no 3331 0.00489568970533161 1077 3834874
SGTC_2463 5473429 200 µM -2.60874231413741 0.00259839134888181 no 3332 0.00454378231540419 1084 5399405
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -2.62588566284116 0.00245505201928301 no 3333 0.00432119211935373 1089 688664
SGTC_2081 5214970 32.255 µM -2.63271570532997 0.00239996554615249 no 3334 0.00423526082361401 1085 2063512
SGTC_2580 diallyl disulphide 81.36 µM -2.64265452549809 0.00232180266295093 no 3335 0.00411294600525329 1071 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2759 disulfiram 3.38 µM -2.67685003579971 0.00207016759784379 no 3336 0.00371589453412777 1077 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3338 9144300 39.5675 µM -2.68980267361435 0.00198150406937183 no 3337 0.00357471401003286 1077 4901274
SGTC_1597 7-benzyloxygramine 47.5 µM -2.69134597421199 0.00197117304161048 no 3338 0.00355821755292891 1072 260807
SGTC_2725 haloperidol 53.21 µM -2.76053092556508 0.00155536150327562 no 3339 0.00288537470721102 1085 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2627 acetyl isogambogic acid 100 µM -2.78581578739808 0.00142455458374393 no 3340 0.00266966024572683 1080 6857789 A caspase activator and apoptosis inducer.
SGTC_1001 4048-4355 44.4 µM -2.81667909667297 0.00127853120967751 no 3341 0.00242614904752756 1085 21824233
SGTC_2163 5671233 125 µM -2.81996094857997 0.0012638375235838 no 3342 0.00240147470707802 1080 701023
SGTC_405 ebelactone b 50 µM -2.93317662744814 0.000842311142505015 yes 3343 0.00167756479931673 1083 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_855 0428-0020 25 µM -3.0198249327045 0.00061179681287978 yes 3344 0.00126460416316389 1087 6812414
SGTC_496 calpeptin 138 µM -3.03098713218414 0.000586766971638348 yes 3345 0.0012187781792611 1087 73364 A calpain inhibitor.
SGTC_981 1488-1094 54.9 µM -3.12799972931976 0.000405845637798712 yes 3346 0.000880001716936642 1092 3449522
SGTC_561 1550-0330 72.9 µM -3.13765460864111 0.000391009996135698 yes 3347 0.000851527148227283 1094 6812934
SGTC_836 0330-0104 1.35 µM -3.2117066661473 0.000292887372604898 yes 3348 0.000659745133651647 1092 46494820
SGTC_3210 9128157 49.47 µM -3.33859855604508 0.000176088322511129 yes 3349 0.00042101077265805 1082 17590849
SGTC_2189 6047310 154.431 µM -3.38438909902435 0.000145929853800426 yes 3350 0.000356684153624543 1094 711535
SGTC_3200 9114385 49.47 µM -3.38550429767649 0.00014525962882024 yes 3351 0.000355237984951787 1086 17018030 YLR208W SEC13
SGTC_582 0987-0078 156 µM -3.4498061417992 0.000111144070105917 yes 3352 0.000280494623482719 1092 1625765
SGTC_1107 amlodipine 47 µM -3.69005414527356 3.92957860382063e-05 yes 3353 0.000112103162781983 1043 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2688 kanamycin b 96.69 µM -4.17255190115245 4.02927725819108e-06 yes 3354 1.50603478795974e-05 1084 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_3066 9117245 49.47 µM -4.49454713592973 7.64964065059414e-07 yes 3355 3.4859079790553e-06 1094 17176980
SGTC_2406 ethylparaben 405.7 µM -4.66909181522265 2.96355703752879e-07 yes 3356 1.51267078542487e-06 1094 8434 A possible steroid mimic.