SGTCid condition conc unit RUB1|YDR139C.score RUB1|YDR139C.strain.pval RUB1|YDR139C.strain.significant RUB1|YDR139C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_310 1273-0058 1.06 µM 6.28027734844122 4.16445016039075e-13 yes 1 1.6898478506723e-10 137 2734232
SGTC_163 TUB2.036 7.546 µM 4.91372714026069 1.09202858839068e-08 yes 2 4.46805474331113e-07 66 15992207 YJR013W GPI14
SGTC_640 3381-0960 37.1 µM 4.73624275741345 3.439798087844e-08 yes 3 1.08858390787831e-06 2 1745025
SGTC_2303 7774051 200 µM 4.46600986808254 1.8282593557228e-07 yes 4 3.98459677740324e-06 12 2953184
SGTC_2415 st077333 57.7 µM 3.8551493933257 5.68872317504164e-06 yes 5 5.78294893010042e-05 48 2766255
SGTC_159 3970-0959 50 µM 3.51361692868684 3.17263721724922e-05 yes 6 0.000221024903419762 108 6615653
SGTC_3018 9082602 49.47 µM 3.47970016467784 3.73341877612836e-05 yes 7 0.00025098761525448 61 17332089
SGTC_2093 5331342 194.4 µM 3.45860934346719 4.12809792650152e-05 yes 8 0.0002714859128251 35 33839
SGTC_1520 flindersine 88 µM 3.45283002465749 4.24294460063867e-05 yes 9 0.000277369216942969 45 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2103 5378138 10 µM 3.30902386135173 8.28752726497068e-05 yes 10 0.00046810928875679 40 244142
SGTC_2693 st077581 40.7 µM 3.27125171206934 9.8390891177346e-05 yes 11 0.000535362812565985 69 25238761
SGTC_2408 sulbentine 18.36 µM 3.07686995752212 0.000231433496905665 yes 12 0.00104593269631399 91 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1679 SEC14.276 6.7 µM 3.07603563075739 0.000232261468446809 yes 13 0.00104886387887156 118 1005053 YMR079W SEC14
SGTC_2457 5731572 11.68 µM 2.97250030334373 0.000359388913869129 yes 14 0.00147692459147862 38 2865357
SGTC_2458 5808907 16.39 µM 2.95233272710835 0.000390688783181772 yes 15 0.001576914462586 28 2731747
SGTC_939 1165-0479 45.3 µM 2.93382903904397 0.000421614109284495 yes 16 0.001674042838763 101 1377347
SGTC_774 k060-0086 136 µM 2.9079398932301 0.000468704817711454 yes 17 0.00181909128976966 66 5911235
SGTC_2736 butenafine 14.65 µM 2.87111107108136 0.000544129642397937 yes 18 0.00204515887945744 81 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_697 0508-1955 564 µM 2.86778024287787 0.000551477477690962 yes 19 0.0020668126994797 96 6243113
SGTC_1630 st005209 31.3 µM 2.85392167020941 0.000583045464924377 yes 20 0.00215915886151245 93 3367314
SGTC_280 3448-3607 3.04 µM 2.84323707976828 0.000608514619599921 yes 21 0.00223289189514387 39 626179
SGTC_156 3474-0145 5.642 µM 2.8371978999606 0.000623361098441447 yes 22 0.00227556965761272 115 2265471
SGTC_3003 9075612 71.4286 µM 2.8200011405583 0.000667488689222394 yes 23 0.00240117393955058 70 6501993
SGTC_1198 1612-1005 86.7 µM 2.76972395661109 0.000813564329050879 yes 24 0.00280519094987912 69 6998509
SGTC_1779 st039427 55 µM 2.74602532061998 0.000892157415329871 yes 25 0.00301610538973601 114 1124498
SGTC_1125 tnp00248 1.32998 µM 2.737324069981 0.000922724057086305 yes 26 0.00309706205407346 134 24207736
SGTC_1673 st016611 27.3 µM 2.68113620778142 0.00114442147021064 no 27 0.00366863221116349 134 5226799
SGTC_2393 9031399 185.94 µM 2.67946322418411 0.00115171462485029 no 28 0.00368701514638746 114 1526623 YDL150W RPC53
SGTC_299 1273-0059 1.44 µM 2.64616312977894 0.00130603010473697 no 29 0.00407052731328191 89 2848077
SGTC_2299 7976368 114.88 µM 2.64384186809272 0.00131746187545367 no 30 0.00409854706977455 92 2979718
SGTC_2487 5918373 44.05 µM 2.62819746270945 0.00139692401877647 no 31 0.00429193360095622 92 2876279
SGTC_1572 epiandrosterone 68.9 µM 2.59199861988566 0.00159783680356055 no 32 0.00477100771909555 105 441302 A steroid.
SGTC_649 1123-0311 367 µM 2.58250511075623 0.00165471824871351 no 33 0.00490429547055176 167 693629 YIL048W NEO1
SGTC_2471 5466956 24.79 µM 2.57136932026781 0.00172378656329478 no 34 0.00506486185592384 64 724419
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 2.56749544033876 0.00174842234668862 no 35 0.00512180683034905 141 6728940
SGTC_478 N-arachidonylglycine 10 µM 2.56178201793684 0.00178534167033666 no 36 0.00520683279192861 33 5283389
SGTC_2107 5363541 170.161 µM 2.54358373485955 0.00190771243805263 no 37 0.00548608774671564 87 244052
SGTC_2602 kawain 100 µM 2.51532328627624 0.00211290701282942 no 38 0.00594616392735039 135 5369129
SGTC_2738 aclarubicin 5.55 µM 2.5070860755069 0.00217637534211698 no 39 0.00608655319677217 61 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2245 6637752 200 µM 2.50403454577852 0.00220032295189546 no 40 0.00613930223679518 71 681890
SGTC_2372 9071633 200 µM 2.49331403620932 0.0022863600313967 no 41 0.0063278429440663 99 21321366
SGTC_1508 1080-0625 72.9 µM 2.4755369598344 0.00243576553080986 no 42 0.00665179956065458 92 767111
SGTC_656 4090-1979 187 µM 2.46732104997382 0.00250775450848969 no 43 0.00680641220963822 136 22330961
SGTC_2097 5376186 200 µM 2.44955516218355 0.00267003968049177 no 44 0.00715163995079012 133 742755
SGTC_2164 5685496 200 µM 2.4463629295508 0.00270018510056139 no 45 0.00721528284481221 104 759046
SGTC_3024 9090631 49.47 µM 2.43520342738238 0.00280799836515868 no 46 0.00744170983514462 71 25236383
SGTC_3025 9087895 49.47 µM 2.41854907905743 0.00297612951848287 no 47 0.00779127165381694 133 17173641
SGTC_1525 8-methoxypsoralen 92.5 µM 2.41459842224058 0.00301732083625947 no 48 0.00787628322636818 150 4114 Related to psoralen; DNA damaging agent.
SGTC_1170 0310-0127 64.8 µM 2.41000394814555 0.0030658703490701 no 49 0.00797617394533837 143 774975
SGTC_1895 st058434 18.3 µM 2.4093636893894 0.00307269148415372 no 50 0.0079901821877045 116 5393175
SGTC_2608 thymoquinone 42.66 µM 2.40643530537157 0.00310406418229232 no 51 0.00805452847304602 121 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 2.38191080357559 0.00337833605906351 no 52 0.00861153430518539 117 688798
SGTC_1254 0550-0035 264 µM 2.36983886098386 0.00352118448171165 no 53 0.00889791966215274 137 15121435
SGTC_1563 conessine 56.1 µM 2.35790864725835 0.00366766108255592 no 54 0.00918910749765694 152 441082 An anti-amoebic, histamine inhibitor.
SGTC_2909 7941780 10.49 µM 2.35779996257681 0.00366902025119497 no 55 0.00919179812362226 131 1243215
SGTC_1239 0337-0584 35.4 µM 2.35177726425985 0.00374504777959343 no 56 0.00934197958302915 205 914301 YML130C ERO1
SGTC_3042 9091578 49.47 µM 2.34872269581843 0.00378414452999245 no 57 0.00941896525603616 81 25236497
SGTC_2616 abietic acid 100 µM 2.34612378387201 0.00381769683257963 no 58 0.00948490312748165 154 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2243 6634756 200 µM 2.33125273651232 0.00401486306610163 no 59 0.00987001841286907 120 885676
SGTC_829 1635-0120 117 µM 2.32589898855285 0.00408804690049223 no 60 0.0100119700082925 164 285054
SGTC_1903 st060211 78.3 µM 2.32078556064833 0.00415905802830522 no 61 0.0101492100987057 159 688960
SGTC_1434 4073-0095 163 µM 2.31800516344376 0.00419813130197389 no 62 0.0102245202193876 109 24133745
SGTC_325 2810-4341 181 µM 2.31664434302862 0.00421737449384493 no 63 0.0102615568648822 104 774970
SGTC_2624 nerol 100 µM 2.31646801218111 0.00421987373093938 no 64 0.010266364509387 117 637566 A natural product oil.
SGTC_1924 st058459 75.1 µM 2.31141442716138 0.00429206634513872 no 65 0.0104049874086611 112 688683
SGTC_874 0599-0792 117 µM 2.301949584048 0.0044302519437629 no 66 0.0106690077485294 166 765305
SGTC_1262 0737-0114 49.6 µM 2.29556986803081 0.00452562378733612 no 67 0.0108502436412183 179 765919
SGTC_2804 7954240 19.48 µM 2.28510953825119 0.0046859692042394 no 68 0.0111532028311997 169 828705
SGTC_1569 carminic acid 40.6 µM 2.26138140396728 0.00506862345811626 no 69 0.0118678246440905 153 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1906 st060206 94.7 µM 2.25112453528022 0.00524247286579995 no 70 0.0121888254207035 169 5133468
SGTC_3021 9087658 49.47 µM 2.23570104040165 0.00551388540848537 no 71 0.0126856804233488 85 25237042
SGTC_545 4218-0007 221 µM 2.23554524748493 0.00551668948582575 no 72 0.0126907872781627 169 2840508
SGTC_2564 betulinic acid 100 µM 2.21961792861476 0.00581013338117229 no 73 0.0132223571025329 209 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2359 9039622 200 µM 2.21079468996515 0.00597858357974995 no 74 0.0135250288629885 173 6463596
SGTC_2046 4110841 106 µM 2.19722630335177 0.00624608010963392 no 75 0.0140021439695921 154 44119630 YMR134W ERG29
SGTC_2746 daunorubicin 9.88 µM 2.19315309013813 0.00632842449093872 no 76 0.0141481755144056 66 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_859 0439-0102 54.6 µM 2.18248952152221 0.00654856802058634 no 77 0.0145367118847731 167 610143
SGTC_3064 1327-0027 10 µM 2.1795573092904 0.00661027712303514 no 78 0.0146451461011508 76 16000455 YPR107C YTH1
SGTC_2918 7977171 22.06 µM 2.17186583324398 0.00677459563437649 no 79 0.0149328921272374 161 2236483
SGTC_2050 5263056 171 µM 2.16687421942861 0.00688315640825224 no 80 0.0151222231081479 220 763468 YGL055W OLE1
SGTC_692 k241-0027 77.8 µM 2.14035707685765 0.00748601649113126 no 81 0.0161629602814571 161 3600480
SGTC_1270 0831-1170 17.3 µM 2.13574483586129 0.00759549555729342 no 82 0.0163501088565226 176 6764716
SGTC_705 1124-0212 310 µM 2.12390401468317 0.00788303719357101 no 83 0.0168390853146172 176 9554485
SGTC_1212 0520-0165 585 µM 2.1201487094148 0.00797620925961635 no 84 0.0169967531388921 201 5403258
SGTC_916 4466-0038 42 nM 2.1101062204018 0.00823014419693215 no 85 0.0174246038118401 297 5722064 YGL116W CDC20
SGTC_2692 st077426 47.7 µM 2.11010276904779 0.00823023267488705 no 86 0.0174247524199757 189 25238571
SGTC_2754 granisetron 64.02 µM 2.10872438625068 0.00826563538364508 no 87 0.017484189312741 213 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_915 methyl methanesulfonate (MMS) 110 mM 2.10010029187996 0.00849019003767316 no 88 0.0178600098297907 216 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1546 5-methoxyflavanone 78.7 µM 2.09838140851284 0.008535580856141 no 89 0.0179357331342918 170 147795
SGTC_281 1672-3440 14.9 µM 2.08580624121612 0.00887418069137055 no 90 0.0184980889250442 166 6833000
SGTC_515 4092-1064 102 µM 2.07239163355103 0.00924830388063807 no 91 0.0191144664865839 273 717353
SGTC_110 0850-0284 111.64 µM 2.07133157437574 0.00927844822359916 no 92 0.0191639102721577 113 3906265
SGTC_1514 1189-1591 158 µM 2.05757106433447 0.00967762019627029 no 93 0.019815663336726 252 767698 YMR146C TIF34
SGTC_1251 0490-5699 265 µM 2.05267490487321 0.00982322741391616 no 94 0.0200520587396221 240 3883818
SGTC_3313 9133968 57.047 µM 2.04676374841063 0.0100015662134164 no 95 0.0203406433266319 200 1494643
SGTC_2440 5628896 157.78 µM 2.04305550106663 0.010114880446359 no 96 0.0205234721334339 171 5522048
SGTC_716 1683-5115 658 µM 2.03890857844988 0.0102429246885524 no 97 0.0207295762974978 227 723597
SGTC_2640 pentamidine 10.38 µM 2.02878373193516 0.0105615040007608 no 98 0.0212401614905321 242 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2260 7964312 200 µM 2.01836393955057 0.0108983431385893 no 99 0.021776686042005 167 231951
SGTC_1603 st002045 67.8 µM 2.01254124684516 0.0110906143707791 no 100 0.0220814566268013 182 5887985
SGTC_544 k015-0020 52.4 µM 2.0067148098436 0.011285955430386 no 101 0.0223900190916847 200 3008304
SGTC_634 1611-4317 11.2 µM 1.99892020107891 0.0115519546715383 no 102 0.0228084943211781 238 2843522
SGTC_279 1273-0055 2.93 µM 1.98586538374757 0.0120096665225568 no 103 0.0235241366658367 243 2847562
SGTC_2809 7964133 12.99 µM 1.97527392079528 0.0123924865734436 no 104 0.0241185355567661 272 1253665
SGTC_987 1497-1013 404 µM 1.97196522243554 0.012514223522223 no 105 0.0243067883730527 177 1676435
SGTC_155 k072-0202 43.6 µM 1.96590498101528 0.01273988452965 no 106 0.024654793797838 200 5857737
SGTC_713 1488-1073 324 µM 1.9624746392043 0.0128691716984023 no 107 0.0248536252022391 187 3312542
SGTC_2090 5301565 104.445 µM 1.95954504872194 0.0129804827406113 no 108 0.025024494787365 269 2056344
SGTC_477 mead ethanolamide 10 µM 1.94994496927066 0.0133510946028037 no 109 0.0255913392377465 88 16061185
SGTC_1707 st032323 6.317 µM 1.94984169293818 0.0133551307712575 no 110 0.0255974952407394 301 3132057 YMR211W DML1
SGTC_1200 1643-0193 18.4 µM 1.94816706572842 0.0134207245258085 no 111 0.0256974880840602 243 5403974
SGTC_3048 9093155 49.47 µM 1.94057609751019 0.0137215563227232 no 112 0.0261548578347945 166 25236002
SGTC_1382 3002-2117 298 µM 1.93938474791072 0.013769294061384 no 113 0.0262272531558253 231 1497314
SGTC_2014 4013930 200 µM 1.93909263706071 0.0137810208771375 no 114 0.0262450295512398 283 64556
SGTC_625 k213-0058 121 µM 1.93892961078137 0.0137875693261572 no 115 0.0262549548885437 413 3655420
SGTC_597 k018-0003 82.8 µM 1.93759782934566 0.0138411649892813 no 116 0.0263361537557661 231 6786234
SGTC_3012 9080433 71.4286 µM 1.9319164048151 0.0140718288192933 no 117 0.0266849123177062 233 17688859
SGTC_1246 0422-0085 105 µM 1.92931241893023 0.0141786520966795 no 118 0.0268460444645907 283 264295
SGTC_2461 5755302 26.15 µM 1.92580650419794 0.0143235782372601 no 119 0.0270642695131748 274 2788904
SGTC_2595 hexamethylquercetagetin 100 µM 1.92250280525339 0.0144613109343145 no 120 0.0272712604771676 227 386331
SGTC_1686 st019653 115.5 µM 1.9191386032065 0.0146027361529798 no 121 0.0274833975693719 207 97252
SGTC_326 k292-0812 17.5 µM 1.91756411024295 0.0146693329176548 no 122 0.0275831522872056 180 3579357
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.91391082325736 0.014824864286975 no 123 0.0278157756125979 275 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_3297 9117502 71.43 µM 1.90490427665166 0.0152143697008315 no 124 0.0283962576202249 190 7453720
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.90484563812312 0.0152169341687489 no 125 0.0284000697160749 199 616764
SGTC_1064 honokiol 6.76 µM 1.90101024231998 0.0153854778117998 no 126 0.0286503355321047 256 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_466 geldanamycin 89.2 µM 1.89843418523314 0.0154995784382288 no 127 0.0288194549688201 150 5288382 HSP90 inhibitor.
SGTC_164 4100-3994 89.624 µM 1.89333245009155 0.0157276931032069 no 128 0.0291568361821818 312 4615967
SGTC_647 0140-0236 81 µM 1.88826148530866 0.0159572798264887 no 129 0.0294954275617446 276 990837
SGTC_2622 2-methoxyxanthone 59.94 µM 1.88368218980996 0.0161670691740455 no 130 0.0298039884704446 239 71034 A hepatoprotective.
SGTC_2383 9036125 200 µM 1.88203552892632 0.0162430824463874 no 131 0.0299155959224257 189 79580
SGTC_2453 5731132 22.18 µM 1.87546879728213 0.0165492686704899 no 132 0.0303641291155299 255 1362040
SGTC_130 0136-0219 337.655 µM 1.86171779935383 0.0172064674965747 no 133 0.031321439162789 264 234244
SGTC_2045 5106652 78.05 µM 1.85927467818059 0.0173255342030943 no 134 0.0314941071535279 229 673349
SGTC_3309 9129340 25.759 µM 1.85560150444677 0.0175058722296035 no 135 0.0317551895512507 259 17158987
SGTC_1678 st019265 80.2 µM 1.85535515796886 0.0175180239824677 no 136 0.0317727631999303 301 5367020
SGTC_551 k048-0028 34.9 µM 1.84283922646675 0.0181449570341162 no 137 0.0326762438338802 284 6836383
SGTC_2425 5628681 7.85 µM 1.84078700110351 0.0182495582837779 no 138 0.0328263892311802 311 5714958
SGTC_996 3970-0799 1.8 µM 1.83773858201321 0.0184058834395562 no 139 0.0330504678540939 424 6615648 YGL040C HEM2
SGTC_2676 harmalol 100 µM 1.83244845494896 0.0186798723327944 no 140 0.0334423172849327 264 5459187 A monoamine oxidase inhibitor
SGTC_1309 pyrazolanthrone 13.4 µM 1.83026624376053 0.0187939017216861 no 141 0.0336050682175881 285 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1540 guanosine 70.6 µM 1.82859847359655 0.0188814483042442 no 142 0.0337298907694127 231 6802 Guanosine is a purine nucleoside
SGTC_2690 usnic acid 100 µM 1.81811091074881 0.019439961421833 no 143 0.0345235913573162 320 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1672 st016598 6.51 µM 1.81700101943651 0.0194998814665281 no 144 0.0346084786250756 328 4665860 YNL267W PIK1
SGTC_945 3381-0768 11.3 µM 1.81261158398053 0.0197383946303416 no 145 0.0349458749412366 300 1126236 YIL048W NEO1
SGTC_2514 salinomycin 42.74 µM 1.80187802682321 0.0203320873527417 no 146 0.0357822990131276 357 23682228 A polyether potassium ionophore.
SGTC_2485 5633444 17.78 µM 1.7877409382679 0.0211370740563764 no 147 0.0369089068042871 324 5724239
SGTC_2641 levomentholum 100 µM 1.78436982086242 0.0213329627616688 no 148 0.0371817958091933 193 16666
SGTC_2076 5212012 200 µM 1.78364379678529 0.0213753508347326 no 149 0.0372407820698244 192 604802
SGTC_862 0452-0056 10.2 µM 1.77837118976143 0.02168532734074 no 150 0.0376714556066004 265 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1988 st071872 53.4 µM 1.77824861746269 0.0216925782989746 no 151 0.0376815156297036 249 16414116
SGTC_2978 9011784 42.97 µM 1.7754584737089 0.0218581885036133 no 152 0.0379111081997374 360 2994934
SGTC_1448 4255-0083 152 µM 1.76358649185331 0.0225748412142351 no 153 0.0389008118063778 280 5399660
SGTC_6 0844-0013 19.835 µM 1.76058294001754 0.0227592587116638 no 154 0.0391545090996526 568 1584900
SGTC_1561 5-methoxyflavone 52.9 µM 1.72893352385712 0.0247808679314228 no 155 0.0419104966490949 219 94525
SGTC_933 2914-0560 114 µM 1.72085256295288 0.0253205302846847 no 156 0.0426387907154311 353 463887
SGTC_2747 doxorubicin 7.63 µM 1.69592107381805 0.0270479070768671 no 157 0.0449504140543213 181 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2441 5730946 39.09 µM 1.69410945081541 0.0271771686259708 no 158 0.0451222433921326 335 1774275
SGTC_182 3448-4371 550.524 µM 1.69395852284791 0.0271879607421584 no 159 0.0451365824707554 353 3491403
SGTC_3230 9131665 49.47 µM 1.69294497743712 0.027260527049235 no 160 0.0452329704890664 155 15943720
SGTC_1101 ebselen 5.29 µM 1.68851628379063 0.0275795039615177 no 161 0.0456560828974638 336 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.68696775489779 0.0276917684235819 no 162 0.0458047761903414 318 6708760
SGTC_1512 0259-0544 12.2 µM 1.68348578648471 0.0279455938236319 no 163 0.0461405443130625 361 18476
SGTC_2876 9059903 25.97 µM 1.68071692560526 0.0281488163057678 no 164 0.046408955704158 337 6916095
SGTC_1753 st043925 64 µM 1.67290027562636 0.0287291739619341 no 165 0.0471734647730302 348 670181
SGTC_2030 5175110 200 µM 1.67069756399463 0.0288945026775248 no 166 0.0473907151405357 318 2831986
SGTC_1491 4138-0063 26.5 µM 1.66545737762075 0.0292909953326291 no 167 0.0479107701670113 283 23883227
SGTC_1898 st060199 18.6 µM 1.66529690600676 0.0293032081843786 no 168 0.047926767756014 308 688866
SGTC_732 3970-1727 52.7 µM 1.651547516888 0.0303654327251557 no 169 0.0493134132735736 304 1275699
SGTC_1793 st048256 72.231 µM 1.65077515547297 0.0304260367976841 no 170 0.0493922474982062 280 672022
SGTC_2605 digitonin 300 nM 1.64465056976858 0.0309101646836645 no 171 0.0500209459302158 411 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3226 9131256 49.47 µM 1.64384889405823 0.0309740037817969 no 172 0.0501037094264026 191 17178073
SGTC_3292 9120825 59.784 µM 1.6371253299209 0.0315137214161818 no 173 0.0508021424866379 343 24824900
SGTC_3125 9127534 49.47 µM 1.63496093505149 0.0316891082029177 no 174 0.0510286185646953 245 1639235
SGTC_2398 5228213 48.84 µM 1.62770553078657 0.0322829261363323 no 175 0.0517936699011989 443 80771 YMR134W ERG29
SGTC_282 k297-0036 65.7 µM 1.6271032998651 0.0323326257360318 no 176 0.0518575801597002 296 5061378
SGTC_1240 0356-0016 42.1 µM 1.6267845338462 0.0323589577067817 no 177 0.0518914337673105 362 4305613
SGTC_399 oxolinic acid 75 µM 1.607897767057 0.0339509887410087 no 178 0.0539287854912967 329 4628 A DNA gyrase inhibitor.
SGTC_676 falcarinol 140 µM 1.60523273243941 0.0341807349323547 no 179 0.0542212982572664 399 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_938 3126-1755 342 µM 1.59966055249152 0.0346652297417863 no 180 0.0548369537263043 364 1777771
SGTC_2270 7924575 90.91 µM 1.59226404183714 0.0353170459015152 no 181 0.0556626944258901 378 1262135
SGTC_798 1287-0182 476 µM 1.58825475231136 0.0356745441918606 no 182 0.0561143723392719 423 1649755
SGTC_1507 4075-3230 155 µM 1.5878488090763 0.0357109059048079 no 183 0.0561602657056319 309 659771
SGTC_1061 3448-9325 110 µM 1.58411030017062 0.0360472067582626 no 184 0.0565843104157226 326 723482
SGTC_1755 st041960 45.185 µM 1.58389161561436 0.0360669587492719 no 185 0.0566091928539261 365 2257073
SGTC_2537 larixol 68.93 µM 1.57484003077597 0.0368923223235865 no 186 0.0576466868946615 413 6708759
SGTC_591 4299-0174 154 µM 1.57418426754734 0.036952712809623 no 187 0.057722427698171 342 5509088
SGTC_1143 3454-2408 5.08 µM 1.57206492729139 0.0371484397583082 no 188 0.0579677471785197 300 X1143
SGTC_553 k007-0256 45.7 µM 1.56754259379203 0.0375689228489186 no 189 0.0584939591882214 403 6287000
SGTC_112 phenothiazine 287.218 µM 1.56248185291411 0.0380440659468838 no 190 0.05908725882072 383 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_742 0kpi-0133 140 µM 1.56208374062338 0.0380816509874517 no 191 0.0591341313517147 401 2728852
SGTC_3293 9120939 62.045 µM 1.55980970134372 0.0382969198100085 no 192 0.059402429107008 369 934087
SGTC_1889 st059080 5.18 µM 1.55813211824399 0.0384563610317433 no 193 0.0596009661884983 413 176925 Isolated from Daphnopsis sellowiana.
SGTC_1395 3486-0190 4.35 µM 1.55442323961089 0.038810781785892 no 194 0.0600417466930974 397 6748079
SGTC_1079 idarubicin 2.36 µM 1.54929431015509 0.0393052816397212 no 195 0.060655493462308 354 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1330 1469-0054 61.8 µM 1.54873291726096 0.039359717615534 no 196 0.0607229687150009 396 7102664
SGTC_3342 9147791 14.508 µM 1.54847988623275 0.0393842730475287 no 197 0.0607534003502074 380 1838168
SGTC_2305 7443522 69.23 µM 1.5433701521728 0.0398828207294433 no 198 0.06137049569099 412 5415886
SGTC_446 go6976 132 µM 1.54045009214416 0.0401700214141966 no 199 0.0617253395988415 353 3501 A protein kinase C inhibitor.
SGTC_3107 9121808 49.47 µM 1.53909555971954 0.0403038148724508 no 200 0.0618904844531298 299 662681
SGTC_2208 7283366 200 µM 1.5357348637607 0.040637329730365 no 201 0.0623017103553714 393 898663
SGTC_397 arbidol 50 µM 1.52737495409451 0.0414766884721652 no 202 0.0633339003850256 416 131410 A RNA synthesis inhibitor.
SGTC_381 3461-2219 42.7 µM 1.52328325942718 0.0418925973115752 no 203 0.063843926768953 420 2883159
SGTC_1217 1183-1422 255 µM 1.52240346133024 0.041982465859474 no 204 0.0639540090400229 400 2849664
SGTC_559 1550-0661 158 µM 1.52185231139448 0.0420388435171784 no 205 0.0640230452894114 390 5830875
SGTC_882 0843-0131 351 µM 1.51838144987047 0.0423952908416103 no 206 0.0644591326446264 429 5425421
SGTC_2048 5246248 200 µM 1.51719832146039 0.0425173519104722 no 207 0.0646083099964089 353 677046
SGTC_2340 7987427 183.45 µM 1.51623286308234 0.0426171668260932 no 208 0.0647302405213839 411 2239331
SGTC_2551 apiole 73.87 µM 1.51380203999265 0.0428693191952193 no 209 0.0650380275399096 257 10659 A possible DNA adduct former.
SGTC_268 camptothecin 39.6153 µM 1.51093347471156 0.0431684285685079 no 210 0.0654027005440981 534 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_780 0109-0199 192 µM 1.50470556148659 0.0438236250204844 no 211 0.0661998963084569 461 610414
SGTC_739 1486-1183 203 µM 1.50105790927221 0.04421107988601 no 212 0.0666702920858866 424 4346692
SGTC_659 k018-0002 107 µM 1.49357462379215 0.0450145997150971 no 213 0.0676434180890746 429 6797879 YHR007C ERG11
SGTC_327 1273-0057 3.96 µM 1.48975856565027 0.0454288523132369 no 214 0.0681438646711862 406 3108138
SGTC_1634 st006576 41 µM 1.48927439812711 0.0454816296458796 no 215 0.0682075632831954 418 3915356
SGTC_1121 fusaric acid 630.51 nM 1.48763207303648 0.0456610208855422 no 216 0.0684239751409712 442 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2522 biochanin a 4.94 µM 1.48305907168447 0.0461635283067666 no 217 0.0690293584357412 385 5280373 A possible chelator.
SGTC_1336 1486-0901 104 µM 1.4828767182688 0.0461836580572721 no 218 0.0690535840673054 429 5006114
SGTC_2002 4023503 131 µM 1.48238974515683 0.046237448920173 no 219 0.0691183105050639 541 4736863 YCR052W RSC6
SGTC_2919 7978188 46.38 µM 1.48192007505481 0.0462893761483064 no 220 0.0691807813787233 444 2980291
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.47847055547891 0.0466721950570883 no 221 0.069640936300189 525 551469
SGTC_1378 2093-0007 380 nM 1.47755708525347 0.046773993933455 no 222 0.0697631840672377 446 3618014
SGTC_648 0375-0473 33.3 µM 1.47017522317938 0.0476031931467137 no 223 0.0707571516642059 475 1713139
SGTC_940 3232-1287 54.8 µM 1.46796102044422 0.0478541955809585 no 224 0.0710574056719294 434 1585493 YIL048W NEO1
SGTC_2644 guaiazulene 100 µM 1.46548959486302 0.0481356070279667 no 225 0.0713936945737092 393 3515 A coloring agent.
SGTC_1736 st036774 51 µM 1.46518867211191 0.0481699621583338 no 226 0.0714347246626452 461 1272247
SGTC_3014 9081533 49.47 µM 1.46394100005861 0.0483126131702819 no 227 0.0716050348146054 438 21367265
SGTC_1012 4112-3522 18 µM 1.46184209083666 0.0485533515189332 no 228 0.0718922434516043 435 3112398
SGTC_1289 0976-0073 69.1 µM 1.45925911994174 0.048850925620736 no 229 0.0722469012127825 454 3391136
SGTC_2584 androsterone 48.74 µM 1.44838311198032 0.0501199297955794 no 230 0.0737549676052382 610 2754130 A steroid.
SGTC_3323 9138564 53.9225 µM 1.4467703006819 0.0503103291531824 no 231 0.0739806337132106 499 43912313 YNL103W MET4
SGTC_1138 3761-0006 1.03 µM 1.4448258310296 0.0505406481733392 no 232 0.0742534067715896 405 12061087
SGTC_1263 0774-1208 64.8 µM 1.44394238812679 0.0506455675676074 no 233 0.0743775909083079 530 906585
SGTC_1809 st050081 57.6 µM 1.44043255480305 0.0510641169080062 no 234 0.0748725294016085 436 5036894
SGTC_188 3229-0966 278.469 µM 1.43651794227554 0.0515341788450314 no 235 0.0754275072840131 542 5722370
SGTC_2589 lobaric acid 100 µM 1.43374761208945 0.0518689110387737 no 236 0.0758221498876478 454 73157 A novel microtubule depolymerizer.
SGTC_2316 5844804 197.44 µM 1.43216453533307 0.0520609647045088 no 237 0.0760483693428467 570 776813
SGTC_2898 9056270 58.44 µM 1.42795150358656 0.0525748287494504 no 238 0.0766529088768957 384 19154699
SGTC_1814 st052110 31.539 µM 1.42512380083862 0.0529219758952762 no 239 0.0770607088883288 424 674163
SGTC_2302 7771753 200 µM 1.4223800622435 0.0532605505336391 no 240 0.0774579739532863 517 2203047
SGTC_2997 9067075 71.4286 µM 1.41315650059375 0.0544113307822542 no 241 0.0788048567140614 514 27209819
SGTC_2857 9024691 58.44 µM 1.41053746869407 0.0547416554755858 no 242 0.0791905204429905 448 16478292
SGTC_2266 7929956 200 µM 1.40796898912001 0.0550671420135211 no 243 0.0795701264167623 503 2967153
SGTC_2150 5556613 200 µM 1.40775741439691 0.0550940215074969 no 244 0.0796014571750519 512 743190
SGTC_1738 st035555 74 µM 1.40710177862947 0.0551773825366405 no 245 0.0796986053949062 482 5331140
SGTC_3207 9114163 49.47 µM 1.40471703797665 0.0554814317253185 no 246 0.0800527186255208 532 849233
SGTC_790 1575-0012 79.1 µM 1.3991852894481 0.0561918102620721 no 247 0.0808787133603522 491 378741 YLR208W SEC13
SGTC_1997 st073024 93.8 µM 1.39763593604877 0.0563920561215683 no 248 0.0811112106116553 466 686268
SGTC_1996 st072960 66.8 µM 1.39611320480338 0.0565894088271977 no 249 0.0813402040041291 493 1719405
SGTC_606 k015-0008 38.6 µM 1.39597686563423 0.0566071054969599 no 250 0.0813607309051187 514 1970475
SGTC_149 3970-0822 46.1 µM 1.3935981158775 0.0569165667307244 no 251 0.0817194989029029 637 3114250 YBL034C STU1
SGTC_865 0488-0499 301 µM 1.39321040375825 0.0569671318019587 no 252 0.0817780873108599 522 9634651
SGTC_133 0724-0033 378.92 µM 1.39203703825574 0.0571203766154292 no 253 0.0819555911971013 449 280309
SGTC_1587 estradiol valerate 56.1 µM 1.38425238503812 0.0581453068655576 no 254 0.0831405940670332 499 13791 A steroid.
SGTC_3190 9110366 49.47 µM 1.38289115514662 0.0583260020964529 no 255 0.0833491213774629 411 17123768
SGTC_737 1950-0117 57.9 µM 1.37976963616182 0.0587420306412872 no 256 0.083828792170576 483 5393513
SGTC_884 0851-0618 334 µM 1.37523187598181 0.0593509619663776 no 257 0.0845297844597453 526 9642473
SGTC_2914 7968218 45.32 µM 1.37318618932601 0.059627090255106 no 258 0.0848472359989082 454 2977111
SGTC_1248 0469-0687 58.6 µM 1.37122326402652 0.0598929928221162 no 259 0.0851526840876486 510 4017482
SGTC_1811 st050069 61.5 µM 1.37037187182604 0.060008612844298 no 260 0.0852854239644733 428 3877702
SGTC_2829 7992743 58.44 µM 1.36970084922705 0.0600998615766443 no 261 0.0853901517520599 501 16462845
SGTC_1624 st003710 6.25 µM 1.36610491023315 0.0605907061501024 no 262 0.0859530186713774 564 24207033
SGTC_328 k915-0120 63.5 µM 1.36287893528382 0.0610337143286295 no 263 0.0864603342384766 477 6624543
SGTC_2650 prasterone 100 µM 1.362108298822 0.061139916002647 no 264 0.0865818548398393 409 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1191 1487-1166 10.6 µM 1.35607907142563 0.061975797948123 no 265 0.0875370054951651 591 3955771
SGTC_2118 5526350 200 µM 1.35603782758482 0.0619815464817042 no 266 0.0875435663177933 516 743594
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.35503351257047 0.0621216555711898 no 267 0.0877034400029892 470 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.35366050576179 0.0623135994409417 no 268 0.0879223568549784 558 688761
SGTC_2174 5790901 200 µM 1.35191494914931 0.0625582925403135 no 269 0.088201262354709 494 786020
SGTC_114 0364-0001 490.298 µM 1.35102159171403 0.0626838133245477 no 270 0.0883442581198681 531 4003655
SGTC_186 3455-3465 67.277 µM 1.3454726101159 0.0634678715266945 no 271 0.0892363303345562 393 755278
SGTC_590 k048-0076 22.4 µM 1.34493994627283 0.0635435354333089 no 272 0.0893223144046546 507 6832814
SGTC_3039 9090270 49.47 µM 1.34289466335509 0.0638347164477687 no 273 0.0896530423603088 470 17173750
SGTC_487 nimodipine 119 µM 1.33576132250935 0.0648583966877373 no 274 0.0908136493090656 391 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1969 st069479 40.1 µM 1.33417890259235 0.065087202116626 no 275 0.0910726160124483 450 3895485
SGTC_1854 st056233 32.9 µM 1.33212826501875 0.0653846394016221 no 276 0.0914090218898022 505 5393174
SGTC_3093 9117344 49.47 µM 1.32945697102344 0.0657736805295129 no 277 0.0918486263974173 503 24824913
SGTC_1370 2001-0092 44.6 µM 1.32926124627053 0.0658022558328019 no 278 0.0918808975266433 606 790957
SGTC_1799 st045822 46.1415 µM 1.32794321252844 0.0659949359659339 no 279 0.0920984338620495 498 3674992
SGTC_3176 9106582 49.47 µM 1.32768817765705 0.0660322693186341 no 280 0.0921405703682309 348 17018027
SGTC_3334 9142812 21.919 µM 1.32133244041599 0.0669679504396438 no 281 0.0931952708937659 528 45283678
SGTC_589 1227-0070 34.1 µM 1.31881755325755 0.0673410073625948 no 282 0.0936150572381352 529 2841384
SGTC_3215 9129942 49.47 µM 1.31821163450416 0.0674311287027383 no 283 0.0937164059352714 473 17682944
SGTC_2685 mycophenolic acid 18.85 µM 1.31620542421848 0.0677301877960131 no 284 0.0940525518132979 474 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1432 4049-0298 68.4 µM 1.31484868846234 0.0679330118983684 no 285 0.094280380214486 509 741646
SGTC_1691 st019933 84.6 µM 1.31441988984032 0.067997212243227 no 286 0.0943524703495135 508 6176082
SGTC_759 3486-0358 89.3 µM 1.3121820792839 0.0683330208953447 no 287 0.0947293534709552 588 875103
SGTC_3336 9143619 71.43 µM 1.31160596607088 0.0684196799616117 no 288 0.0948265594969288 587 45595730
SGTC_1035 k081-0041 55.2 µM 1.30708691003262 0.0691023811445992 no 289 0.0955915982094717 570 731709
SGTC_994 3910-0338 138 µM 1.30572543170021 0.0693090875614014 no 290 0.0958229731183873 580 3479481
SGTC_1082 camptothecin 424.86 nM 1.30470760664757 0.0694639297257448 no 291 0.0959962151675187 478 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.30448539061764 0.0694977709503501 no 292 0.0960340687442386 516 756377
SGTC_2519 cryptotanshinone 88.04 µM 1.30441336694957 0.0695087421409768 no 293 0.0960463400314964 521 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2371 9071574 200 µM 1.29992981302409 0.0701943401819262 no 294 0.0968125129775878 475 45596039
SGTC_394 menadione 8.33 µM 1.2966523380134 0.0706987939240853 no 295 0.0973754177700739 571 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2158 5657123 3.6195 µM 1.29573781458222 0.0708400490748331 no 296 0.0975329143497898 528 2858827
SGTC_873 0591-4978 488 µM 1.29215889336096 0.0713949261650258 no 297 0.0981510620057579 602 3305145
SGTC_1291 0993-0025 5.79 µM 1.28846273740117 0.0719714746626463 no 298 0.0987924659738925 557 4353356
SGTC_1299 1079-1439 3.74 µM 1.28490105156609 0.0725304186780876 no 299 0.099413431722653 543 323161
SGTC_2057 5236571 38.335 µM 1.27815185042857 0.073598699517917 no 300 0.100597944831412 595 54684039 YBR257W POP4
SGTC_2417 cerulenin 830 nM 1.27004385072065 0.074897912642852 no 301 0.102034505310594 530 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2437 5741531 144.16 µM 1.26719551909134 0.0753584539986256 no 302 0.102542693804097 603 2262990
SGTC_2967 9089538 49.85 µM 1.26413744369442 0.0758553078355426 no 303 0.103090349568321 602 728216
SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.26375494511003 0.0759176285523592 no 304 0.10315899855913 549 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_3314 9135860 59.4275 µM 1.26287937146481 0.0760604330409863 no 305 0.103316267231336 595 25252478
SGTC_2791 5663188 71.43 µM 1.26169957010324 0.076253179834953 no 306 0.103528455833668 531 54690634
SGTC_3168 9103419 49.47 µM 1.2594679545403 0.0766187801071485 no 307 0.103930678949014 466 16649256
SGTC_1654 st012436 41.8 µM 1.25775731542009 0.076899931534729 no 308 0.104239768483247 528 4323132
SGTC_1875 nocodazole 6 µM 1.25497419026881 0.0773590259541988 no 309 0.104744064752639 572 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1783 st039459 87.517 µM 1.25439106791705 0.0774554789961325 no 310 0.10484994876322 643 729761
SGTC_669 0108-0021 26.2 µM 1.25381905439688 0.0775501832606253 no 311 0.104953890898228 693 17201
SGTC_2510 benzyl isothiocyanate 8.31 µM 1.25370558153319 0.0775689806130985 no 312 0.104974519224934 535 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2123 5259487 200 µM 1.25363749777487 0.077580260691707 no 313 0.104986897636956 613 2173474
SGTC_2281 7943571 200 µM 1.25062432168363 0.0780807302765761 no 314 0.105535786373506 613 1244024
SGTC_1282 0886-0010 32.4 µM 1.24698809493324 0.0786879413897502 no 315 0.106200931410778 661 2836211 YNL267W PIK1
SGTC_1234 0326-0494 15.5 µM 1.24577526586397 0.0788912647493325 no 316 0.106423456273386 568 1547813
SGTC_3034 9090421 49.47 µM 1.24405693166205 0.0791800140055274 no 317 0.106739305225991 529 17173761
SGTC_895 0964-0006 13.7 µM 1.23076978538309 0.0814398653200278 no 318 0.109204489564535 587 6738897
SGTC_1256 0570-0116 285 µM 1.22982826430993 0.0816018242716374 no 319 0.109380710825647 564 410638
SGTC_2648 atorvastatin 78.68 µM 1.22815918743996 0.0818895328808772 no 320 0.10969360803032 577 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.22579530254481 0.0822983167864007 no 321 0.110137857685678 593 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1751 st044839 27.194 µM 1.22538681556079 0.0823691114244507 no 322 0.110214756064849 583 5291326
SGTC_324 1315-0088 19.6 µM 1.2225524579817 0.0828615957413125 no 323 0.110749389521667 518 6787421
SGTC_464 bw-b 70c 158 µM 1.21837161222512 0.0835920786678316 no 324 0.111541393862714 663 5353454
SGTC_152 4469-0003 551.229 µM 1.20990422903438 0.0850863180805887 no 325 0.113157822140924 601 697280
SGTC_778 3456-2434 196 µM 1.20633437991636 0.085722254409119 no 326 0.113844293287045 692 5539063
SGTC_2906 7926292 26.41 µM 1.2047674697427 0.0860025062806051 no 327 0.114146540695095 609 2966319
SGTC_896 0964-0007 44.5 µM 1.20429972234333 0.0860862986123824 no 328 0.114236876987071 637 6756758
SGTC_1913 st060213 96.1 µM 1.20198937791163 0.0865010700847426 no 329 0.114683821770115 665 688959
SGTC_2368 9071271 200 µM 1.19983314401 0.0868895205709507 no 330 0.115102074572015 601 27209959
SGTC_997 3996-0078 137 µM 1.19878999547106 0.0870779132756076 no 331 0.115304806838849 646 735687
SGTC_1553 gossypol 38.6 µM 1.19721556550257 0.0873628328957703 no 332 0.115611272202115 489 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1417 3966-0327 90.4 µM 1.19304967958517 0.0881200761713793 no 333 0.116424958591741 691 651118
SGTC_284 0988-0104 32.6 µM 1.19272615442825 0.0881790882581236 no 334 0.116488319529832 644 4666532
SGTC_2219 9098279 200 µM 1.18615159379757 0.0893847006696797 no 335 0.117781219258962 608 902349
SGTC_1548 st061468 90.8 µM 1.1854223096101 0.0895191852734717 no 336 0.117925257613683 647 390799
SGTC_1606 st000094 49.2 µM 1.18527627102408 0.0895461337841651 no 337 0.117954116151048 676 1242210
SGTC_727 3032-0951 202 µM 1.18500872451714 0.0895955198098153 no 338 0.118006998705816 582 3652836
SGTC_1293 1000-1278 195 µM 1.18253118095068 0.0900538085267977 no 339 0.118497500418071 644 678847
SGTC_686 1319-0111 510 µM 1.18186960716338 0.0901764786341432 no 340 0.118628721573734 687 4562600
SGTC_2478 5763493 32.33 µM 1.1815977275355 0.0902269269771243 no 341 0.11868267783067 659 1365576 YLR208W SEC13
SGTC_898 1000-0849 28.3 µM 1.18097471830971 0.090342607861159 no 342 0.118806383391219 653 6751807
SGTC_3257 9139206 32.98 µM 1.18072287438235 0.0903894017046221 no 343 0.118856415705771 573 4910041
SGTC_2254 7938975 95.19 µM 1.17938708085177 0.0906378996602559 no 344 0.119122038549005 741 2969277
SGTC_3302 9125395 16.351 µM 1.17861122105982 0.0907824656245955 no 345 0.119276510695882 633 17599668
SGTC_3265 9137266 49.47 µM 1.17606083229633 0.0912588852410245 no 346 0.119785284026487 566 17224265
SGTC_2163 5671233 125 µM 1.1723522460727 0.091954963389889 no 347 0.120527831790093 691 701023
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.17165773341523 0.0920857549735622 no 348 0.120667249427443 889 16725076
SGTC_27 0485-0001 32.618 µM 1.17145705837365 0.0921235720107849 no 349 0.120707554405758 548 2054479
SGTC_2379 9035213 200 µM 1.16698150663472 0.0929699760000563 no 350 0.121608918994355 698 646551
SGTC_539 4859-0462 2.54 µM 1.16411611434921 0.0935148812869944 no 351 0.122188479529191 653 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2021 4019055 173 µM 1.16192732364843 0.0939327051250153 no 352 0.122632493601637 792 44827708 YER133W GLC7
SGTC_1644 st010134 20.9 µM 1.16147511774915 0.0940191993224868 no 353 0.122724368165658 614 3818134
SGTC_39 0986-0283 58.349 µM 1.15945031857822 0.0944072069022106 no 354 0.123136338138675 737 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_3124 9127567 49.47 µM 1.15587819995536 0.09509460057441 no 355 0.123865490368011 638 17592030
SGTC_3253 9135987 49.47 µM 1.15549103050004 0.095169325625984 no 356 0.123944701787207 588 4182430
SGTC_189 3970-0742 2.116 µM 1.15520417452548 0.0952247177079687 no 357 0.124003412821425 642 2891807
SGTC_2572 astragaloside iv 100 µM 1.15313918638026 0.0956241690272712 no 358 0.124426629866506 641 45006101 An anti-inflammatory agent.
SGTC_941 3237-0776 460 µM 1.1530871471011 0.0956342514091527 no 359 0.124437308290763 622 760008
SGTC_3345 9148410 3.559 µM 1.15231244409507 0.0957844392272721 no 360 0.124596352594539 625 4903596
SGTC_1788 fluconazole 20 µM 1.15199302532131 0.0958464138477068 no 361 0.124661969706723 623 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2959 9079155 11 µM 1.15128992312479 0.0959829358218973 no 362 0.12480649068627 584 16189457
SGTC_1973 st070275 50.2 µM 1.14747308010389 0.0967265514650303 no 363 0.12559307637749 625 17118334
SGTC_967 1306-0166 352 µM 1.14550121819348 0.0971123725876499 no 364 0.126000795549581 665 4437607
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.14098419476786 0.0980004433642929 no 365 0.126938250127616 713 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_840 0245-0196 390 µM 1.1393163701292 0.0983298463703636 no 366 0.127285611484699 726 3827528
SGTC_1946 st076057 65.1 µM 1.13764229586976 0.0986612984188593 no 367 0.127634938858412 540 953009
SGTC_2025 5147754 141 µM 1.13642973353492 0.0989018853231921 no 368 0.127888378847872 652 315777 YLR208W SEC13
SGTC_856 0433-0016 11.3 µM 1.13326958312623 0.0995309135323169 no 369 0.128550530503144 696 3911780
SGTC_846 0335-0850 148 µM 1.13227123858139 0.0997302405609291 no 370 0.128760209029042 656 6819598
SGTC_2770 toltrazuril 17.5 µM 1.13208116664898 0.0997682228823281 no 371 0.128800155989373 714 68591 Kills coccidiodes.
SGTC_1725 st036284 20.55 µM 1.1268946001715 0.100808743167406 no 372 0.129893523343355 743 707914
SGTC_1312 1218-2183 165 µM 1.12609601181808 0.100969655088385 no 373 0.130062440981437 713 6744073
SGTC_917 harmaline 728.087 nM 1.12215540818219 0.101766410767193 no 374 0.130898184298621 688 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2752 diclazuril 33.15 µM 1.11780337185763 0.102651662318592 no 375 0.131825490555898 865 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1114 scopoletin 1.73284 µM 1.11643046388575 0.102932084743417 no 376 0.132118959775051 693 5280460 A coumarin with genotoxic properties.
SGTC_2121 5257820 149.641 µM 1.11436216725045 0.103355593434469 no 377 0.132561923422139 752 791256
SGTC_443 clozapine 122 µM 1.11377744965428 0.103475550456704 no 378 0.132687336723025 595 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3136 9095672 49.47 µM 1.11182029814818 0.103877802600145 no 379 0.133107711323595 609 17217380
SGTC_1760 st045453 10.4495 µM 1.11077020753958 0.104094094009729 no 380 0.133333636675053 729 3323419 YIL048W NEO1
SGTC_1088 bifonazole 369 nM 1.10780043728046 0.104707556665262 no 381 0.133974005604941 701 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_3165 9101544 49.47 µM 1.10610733245907 0.105058469483917 no 382 0.134340032691223 706 5002184
SGTC_223 busulfan 5 mM 1.10569200130438 0.105144680862884 no 383 0.134429926637153 615 2478 A DNA alkylator.
SGTC_411 enrofloxacin 100 µM 1.1050973875153 0.105268195508429 no 384 0.134558696249347 700 71188 A bacterial gyrase inhibitor.
SGTC_847 0342-0274 5.54 µM 1.10429246526665 0.105435563138607 no 385 0.134733145124521 720 18097
SGTC_2917 7979103 53.79 µM 1.10426861611314 0.10544052503166 no 386 0.134738316260734 748 2980565
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.10416050141408 0.105463020760675 no 387 0.134761760135644 781 5024745
SGTC_2910 7948405 25.97 µM 1.10265041243467 0.105777592135216 no 388 0.135089504373348 648 2971328
SGTC_2182 6325192 200 µM 1.09926906407163 0.106484429937721 no 389 0.135825360947837 680 736248
SGTC_2160 5660466 132.927 µM 1.09917511928113 0.106504116748379 no 390 0.135845844539072 677 2859134
SGTC_1412 3909-8563 178 µM 1.09344401103294 0.10771008615163 no 391 0.137099449457318 785 23767530
SGTC_2261 9010538 184.68 µM 1.09288574283194 0.107828083545902 no 392 0.137221984400418 611 6457250
SGTC_3086 9117350 49.47 µM 1.09227675812421 0.107956906694596 no 393 0.137355736453029 650 2679265
SGTC_2078 5212016 200 µM 1.09227494651711 0.107957290082836 no 394 0.137356134471268 669 1899708
SGTC_3144 9087057 49.47 µM 1.09128258132273 0.108167450530463 no 395 0.137574279959855 692 17249618
SGTC_621 3584-0052 32.1 µM 1.09043013576437 0.108348214180577 no 396 0.137761856508402 747 2273927
SGTC_3219 9131112 49.47 µM 1.08935826069687 0.108575816904308 no 397 0.137997965042002 686 17612988 YMR079W SEC14
SGTC_1618 st003135 44.5 µM 1.08424424943821 0.109666464809163 no 398 0.139128258457304 704 1270615
SGTC_2110 5483698 200 µM 1.08273414963702 0.109990017784866 no 399 0.139463220788628 703 2848765 YHR062C RPP1
SGTC_2585 alliin 100 µM 1.07989955319998 0.110599204909819 no 400 0.140093456133335 733 87310 A garlic compound which reacts with lipids.
SGTC_2052 5265182 7.135 µM 1.07540178545438 0.11157078305468 no 401 0.141097441390837 736 1239884
SGTC_1832 st054113 55 µM 1.07366095665595 0.111948459906203 no 402 0.141487333186016 699 1251267
SGTC_2462 5162487 171.77 µM 1.07337492733441 0.112010601969479 no 403 0.14155146466979 750 2259986
SGTC_3139 9095020 49.47 µM 1.07265745792323 0.112166586209424 no 404 0.141712417269425 571 25236292
SGTC_514 4466-0038 2.65 nM 1.07236541659888 0.11223012303546 no 405 0.141777967477849 791 5722064
SGTC_1215 3852-0577 11.2 µM 1.06842591717021 0.11308971950019 no 406 0.142664215693842 808 2884876
SGTC_2367 9070478 135.38 µM 1.06499626901809 0.113841883559432 no 407 0.143438809066828 735 572802
SGTC_512 prima-1 270 µM 1.06366410569523 0.114135002590428 no 408 0.143740445238365 757 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2549 cedrol 20.94 µM 1.06324043621897 0.114228336151643 no 409 0.143836464586631 678 6708665 A sedative which affects the nervous system.
SGTC_2935 9038016 29.96 µM 1.06114813376668 0.114690063345939 no 410 0.144311293012958 788 6463195
SGTC_3262 9137218 49.47 µM 1.05876959172953 0.115216568796502 no 411 0.144852362704322 594 17650664
SGTC_1880 MG-132 525 µM 1.05836001073425 0.1153074053016 no 412 0.144945671690942 690 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2639 lactacystin 53 µM 1.05335341466584 0.116421879418574 no 413 0.146089523268417 775 3870 A proteasome inhibitor.
SGTC_1856 st057054 55.7 µM 1.04743445212873 0.117749277752866 no 414 0.147449624451621 794 1266018
SGTC_2934 9036370 36.88 µM 1.04661387409112 0.117934144219208 no 415 0.14763885019018 779 6462800
SGTC_2704 st078022 71.1 µM 1.04507490992911 0.11828140799417 no 416 0.147994174555322 779 54697681
SGTC_1181 1222-0449 220 µM 1.04428028277732 0.118460996557326 no 417 0.148177866261455 772 658318
SGTC_1333 1482-0047 286 µM 1.04322723197514 0.118699286592551 no 418 0.14842153197855 797 3811116
SGTC_2170 morpholine 200 µM 1.04224350433222 0.118922195564407 no 419 0.148649398954393 771 121171 Reacts with secondary amines.
SGTC_2229 7354935 190 µM 1.04087260208787 0.119233329643597 no 420 0.148967339454571 704 318112
SGTC_2938 9059746 27.26 µM 1.03757205440996 0.119984763298615 no 421 0.149734666937323 726 6471769
SGTC_193 1273-0060 1.558 µM 1.03463195356007 0.120656940042165 no 422 0.150420412716236 660 2847393 YHR072W ERG7
SGTC_1177 0983-0204 23.6 µM 1.03366981121834 0.120877483234079 no 423 0.150645275383873 815 766818
SGTC_1552 6-methylflavone 10.6 µM 1.03229690004541 0.121192674232085 no 424 0.150966526423894 735 689013
SGTC_322 k048-0136 19.3 µM 1.03169978238886 0.121329939878716 no 425 0.151106389700988 721 6823282
SGTC_725 1497-0963 19 µM 1.02581504155339 0.122688575809651 no 426 0.152489387340955 807 3549977
SGTC_1423 4048-0112 5.59 µM 1.02540750541145 0.122783059019506 no 427 0.152585474130964 796 X1423
SGTC_45 0kpi-0036 14.9 µM 1.02373944555978 0.123170313981661 no 428 0.152979179381324 734 2795021
SGTC_1008 4106-0037 6 µM 1.02114013344426 0.123775472264703 no 429 0.153594025508041 770 2905394
SGTC_646 4092-0839 27.3 µM 1.0210625534612 0.123793565965183 no 430 0.153612401535024 802 877796
SGTC_2275 7947463 200 µM 1.01908219806362 0.124256064132909 no 431 0.154081972411485 746 1225414
SGTC_1209 2323-2347 50.3 µM 1.01778508662203 0.124559649734557 no 432 0.154390050421657 783 5412760
SGTC_875 0709-0210 25.7 µM 1.01685628641825 0.1247773513699 no 433 0.154610900574083 835 6251364
SGTC_1938 st074717 56.4 µM 1.0158719660216 0.125008356447882 no 434 0.154845180086494 721 17250979
SGTC_771 0250-0039 27.3 µM 1.01477092143705 0.125267108700372 no 435 0.155107519013375 757 3005115
SGTC_2745 rifampicin 24.3 µM 1.01450188323346 0.125330391142035 no 436 0.155171665629656 644 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_3287 9117173 37.0625 µM 1.01449226557523 0.125332653794799 no 437 0.15517395908627 756 2789709
SGTC_257 daunorubicin 18.5 µM 1.01254526554945 0.125791292863475 no 438 0.155638707561444 790 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1636 st007707 68.9 µM 1.0124951520829 0.125803113121526 no 439 0.155650681741212 820 403051
SGTC_2716 st080858 38.6235 µM 1.00957329606278 0.126493630772957 no 440 0.156349884444247 830 5296050
SGTC_2856 9022925 19.48 µM 1.00794225817719 0.12688023767144 no 441 0.156741091577816 792 4944862
SGTC_2863 9028737 58.44 µM 1.00769952479351 0.126937843302946 no 442 0.156799366604724 787 6460917
SGTC_2603 homopterocarpin 100 µM 1.00687334822576 0.127134048440039 no 443 0.156997820537742 786 101795 A weak amylase inhibitor.
SGTC_418 lividomycin a 100 µM 1.00680834564904 0.127149494573546 no 444 0.157013441662232 848 72394 An antibiotic.
SGTC_628 1636-0253 16 µM 1.00647932416482 0.127227697810031 no 445 0.157092526297529 809 4456143
SGTC_592 k241-0073 46.5 µM 1.00451079938482 0.127696284215199 no 446 0.157566234254614 858 4230158
SGTC_1405 3909-7894 12 µM 1.0018686370125 0.128327106573024 no 447 0.15820352093664 800 7104060
SGTC_562 3772-2733 112 µM 0.999464946991746 0.128902869791013 no 448 0.158784755731417 883 2876874 YIL048W NEO1
SGTC_1742 st038235 28.8875 µM 0.999189346425305 0.128968999551023 no 449 0.158851487870897 775 564103 YBR002C RER2
SGTC_111 0083-0039 52.457 µM 0.997095639924616 0.129472148200144 no 450 0.159359044590454 695 759313
SGTC_1590 st077108 57.8 µM 0.994331626547868 0.130138462038234 no 451 0.160030721656725 800 5489485
SGTC_3160 9100216 49.47 µM 0.992983381552099 0.130464339711156 no 452 0.160359026596435 819 17191039
SGTC_2861 9024595 19.48 µM 0.986796635812784 0.131966941837131 no 453 0.161871172151668 746 16482810
SGTC_757 1066-0008 322 µM 0.984116910432708 0.132621468899831 no 454 0.162529016618272 844 6842497
SGTC_198 3454-2873 16.191 µM 0.982415064703837 0.133038306570642 no 455 0.16294770382825 794 710957
SGTC_1726 st035556 14.5795 µM 0.982007865080428 0.133138176635608 no 456 0.163047986741705 866 5919439
SGTC_2188 6126565 140.678 µM 0.980383279156864 0.133537137216304 no 457 0.163448480160279 790 874518
SGTC_2386 9075165 157.42 µM 0.979543255423176 0.133743749690399 no 458 0.163655813453134 816 16452277
SGTC_2080 5212524 12.4 µM 0.976916866874614 0.134391154160454 no 459 0.164305155382832 804 260183
SGTC_1642 st009582 77.7 µM 0.975916308923864 0.134638356680428 no 460 0.164552969729189 792 6739311
SGTC_1480 1070-0044 41.2 µM 0.97586957656258 0.134649910219287 no 461 0.164564550138695 834 3124987
SGTC_2828 7998861 71.43 µM 0.97110063818555 0.135832503135468 no 462 0.165749083024562 763 2988188
SGTC_1066 ketoconazole 628 nM 0.970723590384571 0.135926305256799 no 463 0.165842970619864 879 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_3133 9127736 49.47 µM 0.967839845593834 0.136645191325943 no 464 0.166562180286933 827 27243420
SGTC_1115 galangin 695.678 nM 0.967732229216222 0.13667206913868 no 465 0.166589058859333 908 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2618 avocadyne 43.43 µM 0.965908190338451 0.137128183302618 no 466 0.167045061811574 826 3015189
SGTC_391 gliotoxin 8.33 µM 0.964334791412771 0.13752245761071 no 467 0.167439051679381 887 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2063 5246145 200 µM 0.962924013512638 0.137876638534367 no 468 0.167792828824627 858 711240
SGTC_2606 farnesol 9.78 µM 0.959583224654882 0.138717835633125 no 469 0.16863250760501 834 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1735 st034310 56.75 µM 0.955486948620829 0.139754023287524 no 470 0.16966575118833 823 871153
SGTC_41 0478-0632 82.643 µM 0.950411522298384 0.141045177223983 no 471 0.170951595778826 931 3750424
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.949373078912007 0.141310343918409 no 472 0.171215448717658 851 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1183 1254-0324 198 µM 0.94855032007233 0.141520675309595 no 473 0.171424684224019 858 5799357
SGTC_3016 9080866 49.47 µM 0.945731453377806 0.142242902712784 no 474 0.172142787720981 878 17066299
SGTC_386 1509-0011 3.07 µM 0.944615264996296 0.142529571652732 no 475 0.172427665445415 925 3107280
SGTC_2999 9069765 71.4286 µM 0.944266058787869 0.142619337931213 no 476 0.172516852864424 873 2097066
SGTC_1979 st071809 45.3 µM 0.938503813158978 0.144106089988606 no 477 0.173992779138888 887 4976333
SGTC_1086 cerivastatin 2.18 µM 0.932739823069349 0.145603712330457 no 478 0.175477159113875 855 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1619 st003326 88.7 µM 0.932508405549847 0.145664057855687 no 479 0.175536922375616 844 2849032
SGTC_2185 6113692 200 µM 0.931682843230327 0.145879472357244 no 480 0.175750227807297 801 874150
SGTC_31 0508-1974 57.237 µM 0.930984103841304 0.146061962069856 no 481 0.175930893493047 854 6810525
SGTC_518 1021-0119 62.6 µM 0.930032873848386 0.146310641140482 no 482 0.176177031975508 815 1097762
SGTC_2187 6125751 200 µM 0.929270468874409 0.146510161015272 no 483 0.17637446772747 882 874498
SGTC_1706 st031321 9.9705 µM 0.92470541207185 0.14770864681074 no 484 0.177559581737274 914 6103185
SGTC_213 1246-0773 967 nM 0.924576204768596 0.147742663484969 no 485 0.177593197640688 905 6251622
SGTC_2333 9017922 200 µM 0.922654950741507 0.148249094963498 no 486 0.17809352468208 886 3163164
SGTC_1977 st070720 65.3 µM 0.922423566467837 0.148310164786816 no 487 0.178153840957539 838 682188
SGTC_2282 7944268 200 µM 0.922022506530016 0.148416057386262 no 488 0.178258418066937 888 2970414
SGTC_806 3966-4455 5.86 µM 0.921870498538442 0.148456205549637 no 489 0.178298064535763 792 714982
SGTC_2748 diazoxide 86.69 µM 0.921649676992807 0.148514541602023 no 490 0.178355668738332 826 3019 A potassium channel activatior.
SGTC_2362 9071156 126 µM 0.92079015385034 0.148741754086259 no 491 0.178579998281548 864 653133
SGTC_2159 5658611 73.75 µM 0.918606233214616 0.149320111923046 no 492 0.179150785247031 924 793844
SGTC_1498 4478-3555 97.6 µM 0.917994302720353 0.149482435641175 no 493 0.179310924293436 864 3437919
SGTC_2239 6685329 187.64 µM 0.916656179409054 0.149837803088716 no 494 0.179661417755586 861 805680
SGTC_2419 paclitaxel 166.5 µM 0.915092205585248 0.150253863608354 no 495 0.180071613251925 917 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_735 3076-0345 636 µM 0.913303784263712 0.150730576155374 no 496 0.180541396316945 934 2888990
SGTC_12 0849-0099 9.267 µM 0.909784711470378 0.151671539829484 no 497 0.181468029463469 883 6071388
SGTC_1103 duloxetine 36.1 µM 0.909555289026483 0.151733020287486 no 498 0.181528543584848 991 60835 A selective serotonin reuptake inhibitor.
SGTC_1295 1013-0063 9.78 µM 0.907311122121657 0.152335283750478 no 499 0.182121147136092 933 6826038
SGTC_291 SEC14.278 35.5 µM 0.906384655849969 0.152584380148982 no 500 0.182366145750395 935 1068044
SGTC_2708 st078559 56 µM 0.905099047510919 0.152930485517237 no 501 0.182706458349515 818 17250902
SGTC_3060 1327-0027 12.5 µM 0.904508330715039 0.153089689884168 no 502 0.182862959492599 879 16000455 YPR107C YTH1
SGTC_1556 plumbagin 1.48 µM 0.903257871215606 0.153427064102615 no 503 0.183194525029147 853 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1141 3253-0389 52.6 µM 0.901649857197214 0.153861629915317 no 504 0.183621448651088 912 5402031
SGTC_1032 k061-1018 98.7 µM 0.900938995382694 0.154053999743755 no 505 0.183810378107451 978 4005393
SGTC_1486 3970-0793 4.53 µM 0.900889867377462 0.154067300392004 no 506 0.183823439585667 937 2844330
SGTC_1067 clotrimazole 1.36 µM 0.900838081692943 0.154081321388299 no 507 0.183837208276948 931 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1031 k035-0009 16 µM 0.899872993837926 0.154342773789379 no 508 0.184093921744564 974 5180959
SGTC_2351 9026858 72.31 µM 0.899786754042453 0.154366151322073 no 509 0.184116872395545 848 1409300
SGTC_2848 9016370 25.97 µM 0.899094136843703 0.154553988075847 no 510 0.184301260420669 952 7894410
SGTC_2041 5107442 45.335 µM 0.898423564810514 0.154735990087413 no 511 0.184479889032499 927 793005
SGTC_764 1951-2361 146 µM 0.896860444130923 0.155160791019959 no 512 0.184896694830293 860 5438930
SGTC_1223 0764-0573 147 µM 0.895874556833418 0.155429115887452 no 513 0.185159882185616 956 1609797
SGTC_2976 9009005 19.48 µM 0.894527393780893 0.155796262419974 no 514 0.185519889833883 926 2993148
SGTC_973 1325-0077 65.9 µM 0.89445051740522 0.155817231010286 no 515 0.185540446902261 983 2835149
SGTC_70 0141-0289 43.283 µM 0.894249813668594 0.155871983183276 no 516 0.185594122593975 1049 352408
SGTC_3209 9113616 49.47 µM 0.890085341109411 0.157010917015847 no 517 0.186710031747988 963 16649353
SGTC_1531 st059297 52.4 µM 0.889640002471916 0.157133035033525 no 518 0.186829609721148 927 7566702
SGTC_2442 5158906 48.48 µM 0.88839929607982 0.157473583225486 no 519 0.187163001947043 932 1893835
SGTC_2806 7952793 58.44 µM 0.88821206025456 0.157525017670679 no 520 0.187213346322173 909 2972490
SGTC_1620 st003704 16.5 µM 0.887320573327871 0.157770064166093 no 521 0.187453166100102 946 2834414
SGTC_563 tetrahydrosecaminediol 614 µM 0.886807236305508 0.157911280653256 no 522 0.187591345504398 972 334274 A psychoactive constituent of the cannabis plant.
SGTC_462 ag-879 158 µM 0.885863923430069 0.15817099770901 no 523 0.187845429294191 964 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1384 3089-0840 101 µM 0.885825200322945 0.158181665112321 no 524 0.18785586400345 894 1069836
SGTC_2499 avocadenofuran 51.48 µM 0.885231355584291 0.15834531601507 no 525 0.18801593207958 930 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1490 4089-0339 670 nM 0.884850654184627 0.15845028758524 no 526 0.188118592639913 902 742542
SGTC_1365 1672-3266 55.4 µM 0.884434064430118 0.158565207015992 no 527 0.188230970545507 952 6415873
SGTC_2184 6075246 200 µM 0.884176505942892 0.158636283806511 no 528 0.188300469407391 906 2267320
SGTC_108 0509-0257 621.132 µM 0.882916103458739 0.158984410341852 no 529 0.188640801130036 945 536624
SGTC_2446 5162541 200 µM 0.882850406478526 0.159002569739416 no 530 0.188658550908003 884 1549321
SGTC_1145 3546-0597 10.2 µM 0.88158956595701 0.159351343816864 no 531 0.188999399803779 945 875334
SGTC_1978 st071761 42 µM 0.881525326649077 0.159369127114503 no 532 0.189016776065357 887 5147680
SGTC_1756 st041558 35.5 µM 0.879767877319887 0.159856143929812 no 533 0.189492534869203 1015 3955792
SGTC_699 0375-0592 111 µM 0.878946000178014 0.160084232737792 no 534 0.189715277741906 981 762578
SGTC_1727 st034309 9.9045 µM 0.877507399096116 0.160483987825986 no 535 0.190105550872389 1000 870305
SGTC_169 k015-0017 16.025 µM 0.876747825946573 0.160695319082397 no 536 0.190311811730061 880 1840002
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.876454789237394 0.160776897400201 no 537 0.190391422105431 823 88881 An O-methylated flavonoid and antioxidant.
SGTC_224 benfluorex 43.875 µM 0.876173266263166 0.160855295879841 no 538 0.190467923761324 924 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_467 ro 31-8220 72.8 µM 0.873913168272949 0.161485591940992 no 539 0.19108277143418 935 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_3096 9117468 49.47 µM 0.873824345514023 0.161510395672813 no 540 0.191106960025186 839 41316311
SGTC_2323 6148992 148.28 µM 0.873590302193256 0.161575764102939 no 541 0.191170704687498 839 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_623 k072-0108 16.9 µM 0.871883291858776 0.162053054610949 no 542 0.191636024741206 929 5382803
SGTC_2314 7727897 200 µM 0.871081787913164 0.162277476487388 no 543 0.191854748694286 928 900724
SGTC_3119 9125183 49.47 µM 0.869317789192469 0.162772110149205 no 544 0.192336667723454 808 22695334
SGTC_309 k408-0051 1.48 µM 0.868991296602548 0.162863767656584 no 545 0.192425945617392 973 3640463
SGTC_1272 0839-0021 27 µM 0.868480645140172 0.163007192067389 no 546 0.192565631702861 947 5027250
SGTC_1777 st045864 34.765 µM 0.867678595261904 0.1632326259627 no 547 0.192785153415219 962 4691462
SGTC_1813 st051246 8.6015 µM 0.86489265506135 0.164017249330282 no 548 0.193548854669109 921 5291959
SGTC_2669 eugenol 100 µM 0.864560311308329 0.164111012657601 no 549 0.193640082074915 921 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_228 caffeine 993.056 µM 0.86320539872613 0.164493630546481 no 550 0.194012272965743 915 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2136 5328288 199.296 µM 0.862417203452778 0.164716477200145 no 551 0.194228988514303 852 262395
SGTC_2215 7188065 200 µM 0.862372860504178 0.164729020102108 no 552 0.194241185057571 948 940217
SGTC_11 0438-0307 1.3 µM 0.861722206122082 0.164913136163861 no 553 0.194420201397389 957 4011476
SGTC_1980 st071811 45.7 µM 0.861230144669282 0.165052463555789 no 554 0.194555650301336 958 4974850
SGTC_1596 piperlongumine 63 µM 0.860457826075131 0.165271299497805 no 555 0.194768360874107 1003 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2116 5511452 16.8835 µM 0.859487993709167 0.165546366639311 no 556 0.195035670595594 948 870744
SGTC_2563 tomatine 8.54 µM 0.854212646762427 0.167047760612687 no 557 0.196493588568546 977 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1435 4092-0789 56.7 µM 0.853635676928533 0.167212500575079 no 558 0.196653442138777 980 2248285
SGTC_1039 k821-0043 94 µM 0.853561997222264 0.167233545594646 no 559 0.196673861292836 993 15992768
SGTC_2153 5569715 200 µM 0.852538438849594 0.167526079569761 no 560 0.196957656975936 959 2054701
SGTC_190 3970-0790 3.722 µM 0.85057290661691 0.168088754315289 no 561 0.197503322521762 950 2832352
SGTC_474 dl-dihydrosphingosine 5 µM 0.849882883966532 0.16828657581276 no 562 0.197695101230376 1003 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_449 xestospongin c 11.1929 µM 0.849066367293107 0.168520855046586 no 563 0.197922181876141 970 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1715 st032160 10.2275 µM 0.848912095538695 0.168565143046016 no 564 0.197965103931094 938 5289825
SGTC_1621 st003705 32.4 µM 0.848771542927289 0.168605499097014 no 565 0.198004213889553 1024 24207032
SGTC_1431 4049-0260 9.09 µM 0.848260968938345 0.168752149479469 no 566 0.198146324699757 986 3854841
SGTC_2516 gossypol 71.55 µM 0.848198753138814 0.168770025107222 no 567 0.198163645766603 997 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_248 streptozotocin 5.23457 mM 0.845926089719923 0.169423832821838 no 568 0.198796988531345 1022 5300 DNA alkylating agent.
SGTC_2211 7117706 200 µM 0.844612961783858 0.16980233793797 no 569 0.199163484846904 955 822771
SGTC_2823 7987624 58.44 µM 0.844263914907274 0.169903040790122 no 570 0.199260972872621 957 2239440
SGTC_3278 9139605 49.47 µM 0.843206374037288 0.170208383594687 no 571 0.199556517105612 950 7958859
SGTC_1689 st020265 53.493 µM 0.83885965935743 0.171467096222102 no 572 0.200774033793492 992 5758320 YPR016C TIF6
SGTC_1492 4158-0558 28.5 µM 0.838203823311005 0.171657527068534 no 573 0.200958120071392 979 3967268
SGTC_1176 0848-0131 83.3 µM 0.836721455655902 0.172088450126066 no 574 0.201374578005781 1057 6769040
SGTC_2983 9022671 12.99 µM 0.836303869871936 0.172209966513607 no 575 0.201491988317886 960 6405161
SGTC_201 4262-0159 12.803 µM 0.835202659591997 0.172530678379809 no 576 0.201801806247232 948 1341029
SGTC_2480 5767542 37.17 µM 0.83436421263439 0.172775119388942 no 577 0.202037888691918 1011 2867358
SGTC_2879 9041815 71.43 µM 0.833460850050663 0.173038732825885 no 578 0.202292434396758 929 4942971
SGTC_511 blebbistatin 171 µM 0.832095345702669 0.173437691583455 no 579 0.202677564376842 991 3476986 A myosin inhibitor.
SGTC_2529 gangaleoidin 93.61 µM 0.830286771984377 0.173967002223559 no 580 0.203188332618858 1002 4565183
SGTC_506 n9-isopropylolomoucine 153 µM 0.830090932278292 0.174024379697135 no 581 0.203243686744832 1000 6610355
SGTC_417 st075190 100 µM 0.829730461937199 0.174130022402719 no 582 0.203345597274097 1020 222757
SGTC_2989 9073649 71.4286 µM 0.829595609394667 0.174169553986127 no 583 0.203383730005074 1047 21367202
SGTC_3201 9113999 49.47 µM 0.8276983082087 0.174726346215364 no 584 0.203920688744156 950 16649224
SGTC_3108 9121785 49.47 µM 0.82763368396066 0.174745331074012 no 585 0.203938993037901 1013 17140271
SGTC_2866 9034245 58.44 µM 0.827536787778923 0.174773799008716 no 586 0.203966439929403 1018 6462273
SGTC_2284 7945075 39.21 µM 0.82705734757346 0.174914701049224 no 587 0.2041022789387 1075 1245402
SGTC_2148 5546263 113.568 µM 0.822772742559201 0.176177096969313 no 588 0.205318619943373 1000 792097
SGTC_1344 1488-0097 29.1 µM 0.820731181738882 0.176780636280376 no 589 0.20589970269075 986 747966
SGTC_871 0574-0004 149 µM 0.819610878882549 0.177112382128141 no 590 0.206218984946354 980 9551173
SGTC_3308 9128332 17.569 µM 0.818116680591844 0.177555458102158 no 591 0.206645282494744 1055 17332805 YDL196W YDL196W
SGTC_2004 4023728 41.89 µM 0.81731497724959 0.177793476035569 no 592 0.206874224910301 1026 360084 YDR527W RBA50
SGTC_809 3998-0021 90 µM 0.816453722890994 0.178049398231934 no 593 0.207120340504064 997 715485
SGTC_1404 3909-7820 48.3 µM 0.815093783355017 0.178453977649929 no 594 0.20750931491188 1028 23741373
SGTC_2711 st079103 59.1 µM 0.814812347666125 0.178537776500235 no 595 0.207589865964627 1004 54693780
SGTC_2117 5521686 200 µM 0.810555001855728 0.17980844393493 no 596 0.208810633452851 1000 803312
SGTC_173 1273-0061 2.693 µM 0.810052973567719 0.179958655201965 no 597 0.208954865242476 993 2847414 YPL266W DIM1
SGTC_2034 5197015 53.07 µM 0.809483806909239 0.180129050142371 no 598 0.209118456719704 1002 780676
SGTC_536 3852-0578 10.6 µM 0.809420889511707 0.180147892327309 no 599 0.209136545242375 1051 2869208
SGTC_338 4055-0136 114 µM 0.808797897154804 0.18033452970839 no 600 0.209315702993067 1035 2900563
SGTC_537 1334-0398 209 µM 0.808483779384337 0.180428679774484 no 601 0.209406070019001 1046 5846986
SGTC_2932 9016711 44.54 µM 0.808481240282727 0.180429440941364 no 602 0.209406800574412 1057 7117328
SGTC_2793 7325131 81.82 µM 0.807243696365549 0.180800669164693 no 603 0.209763047657316 992 4176441
SGTC_1420 4'-methoxyflavone 42 µM 0.804645135350425 0.181581720921817 no 604 0.210512244145053 1056 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_323 4013-0906 34.3 µM 0.803784940673427 0.181840734896357 no 605 0.210760594202894 1064 2910086
SGTC_1301 naphtanilide LB 4.81 µM 0.8027704398059 0.182146508981201 no 606 0.211053715334537 1095 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3261 9137475 49.47 µM 0.802267322560172 0.182298269415752 no 607 0.211199170285246 879 17027690
SGTC_2180 6301957 200 µM 0.800532148608523 0.182822273717389 no 608 0.211701272443501 1047 845462
SGTC_2198 6589944 200 µM 0.79935238549291 0.183179086154625 no 609 0.212043055630004 965 5290268
SGTC_1319 1306-0155 43.7 µM 0.799219551152499 0.183219288310418 no 610 0.212081558594106 1065 3122360
SGTC_751 0833-0568 350 µM 0.798478119529893 0.183443782774549 no 611 0.212296542822689 1044 6954252
SGTC_1058 3448-5425 97.3 µM 0.7973887306673 0.18377394442348 no 612 0.212612651071625 1014 7279705
SGTC_3111 9122088 49.47 µM 0.794942792177281 0.184516583787301 no 613 0.213323390292421 954 16876704
SGTC_2001 4023502 57.655 µM 0.794108042075744 0.184770458420183 no 614 0.213566268116982 1024 108941 YCR052W RSC6
SGTC_745 0469-0705 296 µM 0.793787141177455 0.184868112564825 no 615 0.213659679893432 1138 3486736
SGTC_1452 4194-0072 190 µM 0.792037597794659 0.185401084408115 no 616 0.214169376936166 1102 1343545
SGTC_3271 9137798 49.47 µM 0.791975292704636 0.18542008228115 no 617 0.214187541406131 983 6498326
SGTC_1961 st076550 68.7 µM 0.791767989514718 0.185483301219795 no 618 0.214247985176978 993 1579337
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.788244382426297 0.186559901744356 no 619 0.215276886536107 1033 803109
SGTC_58 0957-0393 9 µM 0.788186140954143 0.186577729251592 no 620 0.215293917234413 1076 6997992
SGTC_255 tunicamycin 200.472 nM 0.784481966012625 0.18771373030449 no 621 0.216378679847046 1054 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2018 5133068 143 µM 0.783804821593667 0.187921858779035 no 622 0.216577322123339 1015 785362
SGTC_1144 3486-0183 12.5 µM 0.782970234925692 0.188178574960922 no 623 0.216822295622927 1068 6744069
SGTC_903 1134-0042 114 µM 0.782307060122349 0.188382719629995 no 624 0.217017069336974 1070 701009
SGTC_2895 9054447 58.44 µM 0.780706758336836 0.188875901754245 no 625 0.217487492392067 1070 2697450
SGTC_2200 6600604 21.907 µM 0.780106727616998 0.189061024524829 no 626 0.217664028418679 1055 2904777
SGTC_1494 4358-1428 177 µM 0.779876246799707 0.189132162661013 no 627 0.217731860532818 1115 1564571
SGTC_2083 5306046 65.942 µM 0.779364587797012 0.189290145632338 no 628 0.217882488929983 1078 539837
SGTC_1887 st057648 70.8 µM 0.777816982888878 0.189768487883147 no 629 0.218338457287755 1071 688672
SGTC_1354 1498-1681 81 µM 0.777156462829251 0.189972871206144 no 630 0.21853323250301 1100 5754243
SGTC_3195 9113082 49.47 µM 0.77521555475035 0.190574224835553 no 631 0.219106149167372 1050 17018038
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.774608322925663 0.190762603859563 no 632 0.219285568882984 1101 4213774
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.774316604309311 0.190853143141859 no 633 0.21937179344736 1068 97141
SGTC_2061 5245884 80.95 µM 0.774299240159226 0.190858533199549 no 634 0.219376926460423 1102 573863
SGTC_3289 9119912 71.43 µM 0.77366206772855 0.191056384383286 no 635 0.219565328604855 1080 17014829
SGTC_2724 maprotiline 69.64 µM 0.773246456103859 0.191185505510378 no 636 0.219688268668106 1085 4011 A tricyclic antidepressant.
SGTC_2374 9071832 200 µM 0.770352800883952 0.192085980898755 no 637 0.220545321664722 1058 17381698
SGTC_73 0327-0325 16.231 µM 0.76794968573143 0.192835774345604 no 638 0.221258538653277 1137 53298
SGTC_2594 a-mangostin 100 µM 0.767674028745663 0.192921895952992 no 639 0.221340434741677 1084 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_3266 9136860 49.47 µM 0.767629013715868 0.192935961918707 no 640 0.221353810091764 1051 4871271 YPR165W RHO1
SGTC_1024 4507-0395 26 µM 0.766221545237386 0.193376073224172 no 641 0.221772245361137 1065 4201836
SGTC_1034 k072-0165 12.7 µM 0.766194468448233 0.193384546058703 no 642 0.221780299619848 1100 5835461
SGTC_2023 5144124 124 µM 0.765666008680226 0.193549956367227 no 643 0.221937528656483 1059 2830192
SGTC_2625 euphol 100 µM 0.764100547633889 0.19404045900086 no 644 0.222403662992692 1099 6708538 A triterpene alcohol.
SGTC_1374 2889-5571 141 µM 0.763969502557539 0.194081553404515 no 645 0.222442708509568 1087 2853281
SGTC_3250 9135583 49.47 µM 0.763517401030374 0.194223368541261 no 646 0.22257744436097 1073 7699353
SGTC_986 1493-0483 84 µM 0.763256800164431 0.194305142445991 no 647 0.222655130085926 1049 40079
SGTC_2894 9048625 32.47 µM 0.762236026058124 0.194625652827899 no 648 0.222959574021165 1122 4092861
SGTC_1117 retinoic acid 1.10837 µM 0.760092573175414 0.195299716565028 no 649 0.223599625843254 1124 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1555 citronellol 128 µM 0.759483597297852 0.195491483083446 no 650 0.223781661238955 1075 8842 A terpine precursor.
SGTC_832 4083-0019 164 µM 0.759001592839529 0.195643347346073 no 651 0.22392580197663 1210 1990758
SGTC_2957 9076800 11.52 µM 0.758410731204028 0.195829606722517 no 652 0.224102567797596 1042 16459615
SGTC_1658 st012944 20 µM 0.758286958911222 0.195868637522483 no 653 0.224139606319747 1055 24207260
SGTC_1213 1315-0166 115 µM 0.757747831998678 0.196038702797119 no 654 0.224300979129746 1026 768401
SGTC_435 c-PAF 6.7 µM 0.757648533631932 0.196070035806442 no 655 0.224330708555508 1091 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1228 0124-0032 52.5 µM 0.757245607498107 0.196197207919239 no 656 0.224451365540607 1131 X1228
SGTC_1687 st020778 55.3625 µM 0.756935450316239 0.196295134225082 no 657 0.224544267769495 1140 4259299
SGTC_1604 st002052 72.4 µM 0.751239061722118 0.198098927111932 no 658 0.226254397926475 1149 6254834 YHR062C RPP1
SGTC_2820 7989630 71.43 µM 0.748814238823777 0.19886978783633 no 659 0.226984588194021 1007 2984098
SGTC_2798 7813637 45.45 µM 0.746225711965095 0.199694682882071 no 660 0.227765539265445 1089 956368
SGTC_1509 1326-1131 80 µM 0.745217110303535 0.200016654084308 no 661 0.228070240395125 1087 768313
SGTC_532 1548-0774 215 µM 0.745167653435354 0.200032449992661 no 662 0.228085187334632 1162 5932993
SGTC_3100 9120536 49.47 µM 0.744794749595145 0.200151574983252 no 663 0.228197904706785 1020 16421196
SGTC_715 0868-0130 184 µM 0.744509129890514 0.200242845685564 no 664 0.228284259942077 1132 2876258
SGTC_2670 beta-carotene 100 µM 0.74350931468852 0.200562536824379 no 665 0.228586692121074 1070 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2338 7999974 200 µM 0.742318645479231 0.200943653129478 no 666 0.228947148748859 1188 315925
SGTC_2638 epoxomicin 18 µM 0.741382256198966 0.201243683038844 no 667 0.229230849983123 1109 9915668 A protesome inhibitor.
SGTC_2240 6690706 185.951 µM 0.740914293245502 0.201393724358225 no 668 0.229372704246118 1029 805876
SGTC_1646 st011709 75.6 µM 0.739198989172744 0.201944269306919 no 669 0.229893087278435 1114 5757843
SGTC_2077 5212015 200 µM 0.739027497273025 0.201999360936442 no 670 0.229945150215069 1072 780900
SGTC_395 anisomycin 6.25 µM 0.738167798605379 0.202275673966973 no 671 0.230206244125169 1059 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1600 coumarin 106 71.1 µM 0.738133020286201 0.202286856712484 no 672 0.230216809927957 1131 100336 A hepatotoxic, DNA x-linker.
SGTC_802 4112-3352 742 µM 0.73652044938003 0.202805774529947 no 673 0.230707013658309 1158 704594
SGTC_886 0866-0150 153 µM 0.736030553445918 0.202963578127455 no 674 0.230856052006674 1161 271463
SGTC_724 3910-0327 137 µM 0.736021630896428 0.202966452908277 no 675 0.230858766963322 1151 2885483
SGTC_455 paf C-16 10 µM 0.735266027887622 0.203209990942158 no 676 0.231088746803032 1123 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1692 fluoroquinolonic acid 71 µM 0.734198767186689 0.20355427622877 no 677 0.231413802372012 1137 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_64 000l-0018 272.079 µM 0.733411289331512 0.203808529882996 no 678 0.231653807861276 1117 6811119
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.731810133272213 0.204326079911134 no 679 0.232142231613869 1109 17037758
SGTC_2899 9053889 58.44 µM 0.731685401871878 0.204366430317634 no 680 0.232180304283676 1117 6470052
SGTC_1641 st009299 47.1 µM 0.730952060000064 0.204603761144816 no 681 0.232404217803983 1103 4046054
SGTC_2511 berberine 10.47 µM 0.730793836393481 0.204654988419736 no 682 0.232452544450545 1131 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_403 arphamenine a 50 µM 0.729955557078391 0.204926521247769 no 683 0.232708675496259 1112 5487158 An arginine aminopeptidase inhibitor.
SGTC_507 nimesulide 162 µM 0.727674928609038 0.205666338588106 no 684 0.233406300604671 1138 4495 A COX2 inhibitor.
SGTC_1421 4029-0249 71.4 µM 0.72719677309587 0.205821649134914 no 685 0.233552711354217 1219 2894095
SGTC_1989 st071868 50.2 µM 0.72568232210312 0.206314019698013 no 686 0.234016770718704 1163 16414057
SGTC_132 0417-1715 25.805 µM 0.7253491292268 0.206422439272772 no 687 0.23411893646529 1172 6769098
SGTC_807 1315-0151 48 µM 0.724394440000373 0.206733278052384 no 688 0.234411806155528 1186 4011080
SGTC_726 3448-4391 34.2 µM 0.72436495885018 0.206742881275959 no 689 0.234420853303573 1212 1356692
SGTC_2144 5628481 200 µM 0.723049344244792 0.20717169990396 no 690 0.234824784528361 1158 2818399
SGTC_3224 9130643 49.47 µM 0.723019728642457 0.207181359026274 no 691 0.234833881788865 1180 17644395
SGTC_1953 st076800 12.1 µM 0.722778057103656 0.207260190101467 no 692 0.234908125241034 1097 297591
SGTC_424 splitomicin 100 mM 0.721879328747709 0.207553502774401 no 693 0.235184335644513 1110 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3068 9116768 49.47 µM 0.721834967826825 0.207567986936571 no 694 0.235197973937774 1135 41904888
SGTC_2091 4-phenylthiadiazole 200 µM 0.720859401926834 0.20788666725316 no 695 0.235498011681776 1152 270010
SGTC_1401 3807-4679 7.6 µM 0.717499968266698 0.20898627484914 no 696 0.236532827995477 1131 3291456
SGTC_811 0416-0114 265 µM 0.71680981211613 0.209212599753013 no 697 0.236745728249712 1180 6612453
SGTC_356 1634-0012 32.5 µM 0.716256125069713 0.209394276216918 no 698 0.236916606504393 1180 735457
SGTC_3076 9116187 49.47 µM 0.715905625336579 0.209509330582086 no 699 0.237024812361749 1115 27241210
SGTC_1984 st072354 53.1 µM 0.714754781842964 0.209887365676694 no 700 0.237380290309249 1127 5762938
SGTC_1489 4065-0444 182 µM 0.712892921240933 0.210499807650612 no 701 0.237956009911677 1156 2877968
SGTC_426 0988-0037 14.6 µM 0.712516950178417 0.210623607047998 no 702 0.238072359514981 1194 5383008
SGTC_2839 9003951 25.97 µM 0.711760109973998 0.210872948194567 no 703 0.23830666902941 1160 2990634
SGTC_2891 9063876 19.48 µM 0.711378591894904 0.21099870498855 no 704 0.23842483075386 1136 6472478
SGTC_2124 5246320 200 µM 0.710653214269838 0.211237926715566 no 705 0.238649579260805 1154 579342
SGTC_1009 4106-0057 9.87 µM 0.710009870881179 0.211450227342101 no 706 0.238849007532482 1199 2928005
SGTC_2138 5575593 77.673 µM 0.708482199725962 0.211954852776419 no 707 0.239322931158981 1172 762213
SGTC_821 1114-0266 29.2 µM 0.707376848639161 0.212320414858567 no 708 0.239666160077298 1168 3123235
SGTC_109 0132-0036 33.701 µM 0.707358863645929 0.212326365906342 no 709 0.239671746921172 1064 67274 A color developer.
SGTC_1720 st037298 9.481 µM 0.705091036109723 0.213077547309302 no 710 0.240376792279775 1171 597396
SGTC_689 0833-0039 98 µM 0.704482973003448 0.213279221694382 no 711 0.240566025035272 1184 5374726
SGTC_3177 9107506 49.47 µM 0.703582037485483 0.213578236684893 no 712 0.240846550429642 1134 8897194
SGTC_225 nsc-122657 1.016 µM 0.70352507577747 0.213597150134032 no 713 0.240864292646201 1105 275685
SGTC_2768 sulfasalazine 50.2 µM 0.702660670390017 0.213884285279886 no 714 0.241133621601372 1212 5384001 An antioxidant and salicylic acid derivative.
SGTC_8 0354-0001 70 µM 0.701669176042114 0.214213912964992 no 715 0.241442750056755 1221 4993152
SGTC_2835 9006588 71.43 µM 0.701226558684727 0.214361158878888 no 716 0.241580818917423 1172 2345538
SGTC_1825 st052143 62.6 µM 0.700473110274928 0.214611944578756 no 717 0.241815946144114 1185 674173
SGTC_358 0075-0058 9.45 µM 0.700423026811335 0.214628620928519 no 718 0.241831579996751 1192 1069125
SGTC_533 1222-0222 6.71 µM 0.700057179921202 0.214750460240559 no 719 0.241945797925098 1237 3982874
SGTC_2946 9065502 71.43 µM 0.699702828967333 0.214868509324386 no 720 0.242056454697578 1017 16489101
SGTC_1714 st033236 13.627 µM 0.698583392730475 0.215241687777969 no 721 0.242406212657785 1217 2916566
SGTC_1951 sophoraflavanone G 9.2 µM 0.698206844992666 0.215367299298759 no 722 0.242523923181969 1218 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_696 1560-0013 611 µM 0.697934083741901 0.215458315528348 no 723 0.242609208912245 1229 1650269
SGTC_3162 9099653 49.47 µM 0.694481714721875 0.216612244859434 no 724 0.243690082032582 1175 25237511
SGTC_1148 3909-7663 27.7 µM 0.694142946672504 0.216725667915064 no 725 0.243796283965682 1249 4084526
SGTC_2612 dictamnine 15.46 µM 0.693965737672071 0.216785013005664 no 726 0.243851847969628 1158 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1313 1220-0047 237 µM 0.692632773179765 0.217231707301101 no 727 0.244270018861813 1218 3528706
SGTC_1093 fluphenazine 7.97 µM 0.692058609452228 0.217424280976859 no 728 0.244450261652065 1257 6602611 An atypical antipsychotic.
SGTC_2257 7960413 200 µM 0.691550715045239 0.21759471014254 no 729 0.24460976073643 1185 2974689 YIL048W NEO1
SGTC_1081 sertraline 6 µM 0.690195591107522 0.218049812929942 no 730 0.245035597788434 1207 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1224 0823-0416 294 µM 0.689691443370255 0.218219265089481 no 731 0.245194123973854 1229 3598164
SGTC_2232 chlorophetanol 41.5365 µM 0.687330115771979 0.219013954611802 no 732 0.245937362540844 1266 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2356 9061756 188.97 µM 0.686345492167837 0.219345814397985 no 733 0.246247634065885 1180 20104043
SGTC_1872 amphotericin b 148 nM 0.686025366532226 0.219453772488686 no 734 0.246348556250732 1216 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_585 0kpi-0023 191 µM 0.685985950137244 0.219467067251327 no 735 0.246360984119489 1168 64601
SGTC_1383 3049-0032 20.7 µM 0.683689390608274 0.220242472679302 no 736 0.24708566214811 1245 712864
SGTC_1693 xanthone 101.9 µM 0.6831806966724 0.220414439281016 no 737 0.247246334347775 1245 7020 An insecticide.
SGTC_2428 5615643 7.78 µM 0.682019512897899 0.220807271638972 no 738 0.247613306235264 1229 2253075
SGTC_1306 1185-0270 9.02 µM 0.68163144190622 0.220938646680499 no 739 0.247736014138875 1215 1548076
SGTC_2707 st078556 66.6 µM 0.680546983850883 0.221306009222516 no 740 0.248079091455819 1188 17250899
SGTC_965 1291-5240 308 µM 0.677202541397282 0.222441143819309 no 741 0.249138727763214 1214 2834598
SGTC_1834 st055981 52.8 µM 0.676409509080886 0.222710792534633 no 742 0.249390340771961 1256 471719 YDL150W RPC53
SGTC_1222 0366-0074 1.18 µM 0.676357940386929 0.222728333492233 no 743 0.249406707144541 1253 286520
SGTC_3264 9137442 49.47 µM 0.675639740525129 0.222972709143406 no 744 0.249634701786464 1271 17015726
SGTC_2686 alizarin 95.37 µM 0.675398313196721 0.223054891815781 no 745 0.249711368451416 1198 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2217 6934799 96.0675 µM 0.675028098414703 0.223180947669215 no 746 0.249828956612131 1183 675606
SGTC_220 paclitaxel 373.376 µM 0.674752099948807 0.223274949828366 no 747 0.249916638771385 1202 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2421 5690543 90.72 µM 0.674136712088466 0.223484625543511 no 748 0.25011220059564 1248 3397993
SGTC_2395 5646831 180.19 µM 0.673572682118958 0.22367690087502 no 749 0.250291512858396 1242 6808628
SGTC_1927 st060202 13.8 µM 0.668408975430354 0.225441552123133 no 750 0.251936283886621 1211 688887
SGTC_910 3454-3003 490 µM 0.668386940816449 0.225449099106624 no 751 0.251943314669961 1206 820824
SGTC_2402 5553605 200 µM 0.668287517810769 0.225483153843166 no 752 0.251975039754327 1277 6758546
SGTC_2925 9010536 32.5 µM 0.665927801546433 0.22629226679567 no 753 0.25272862465519 1249 2994177
SGTC_3049 9092223 49.47 µM 0.665839426949428 0.226322601009844 no 754 0.252756870476739 1205 8623917
SGTC_1655 st012546 55.1 µM 0.665822404207284 0.226328444259349 no 755 0.25276231138652 1216 720985 YLR208W SEC13
SGTC_2991 9074669 71.4286 µM 0.663628508003078 0.227082236893182 no 756 0.253464053319534 1256 17333109
SGTC_275 trichlorophene 5.69 µM 0.663155432165646 0.22724496457123 no 757 0.253615505921405 1281 62616
SGTC_3084 9116877 49.47 µM 0.662103371288334 0.227607085835631 no 758 0.253952487693012 1179 27241325
SGTC_2871 9038510 12.99 µM 0.659963849278241 0.228344514478774 no 759 0.254638514267806 1267 4945164
SGTC_1439 4092-1168 46 µM 0.659701173603849 0.228435143306717 no 760 0.254722806699908 1250 2886240
SGTC_180 1486-1293 102.781 µM 0.658539509849717 0.228836184833637 no 761 0.255095758858352 1295 4140536
SGTC_1334 1486-0610 236 µM 0.658218178525651 0.228947187879815 no 762 0.25519897268943 1254 3742339
SGTC_3331 9141060 1.957 µM 0.657831095082046 0.229080944931723 no 763 0.255323335543908 1240 4906567 YPR165W RHO1
SGTC_1203 3992-3522 103 µM 0.657232176595346 0.229287988140909 no 764 0.255515819544949 1433 5322312
SGTC_3197 9113331 49.47 µM 0.656158824663822 0.229659303042642 no 765 0.255860969379725 1309 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_704 1310-0270 142 µM 0.656143839248394 0.229664489473663 no 766 0.25586578985055 1234 5718033
SGTC_1851 st056236 18.9 µM 0.654573275090012 0.230208423115391 no 767 0.25637126767011 1270 5393171
SGTC_2568 diosmetin 100 µM 0.651801375222041 0.231170171278138 no 768 0.257264657190986 1264 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1844 rapamycin 4 nM 0.650251235707997 0.231708989083489 no 769 0.257764975242303 1232 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2781 5567276 71.43 µM 0.649002862215056 0.232143423322735 no 770 0.258168263084346 1275 2853274
SGTC_345 1362-0200 395 µM 0.6489857305903 0.232149388283508 no 771 0.258173799740991 1251 1419823
SGTC_988 1497-1057 103 µM 0.64851931756909 0.232311818693173 no 772 0.258324560333115 1279 3533044
SGTC_2975 9084847 53.72 µM 0.648486863082798 0.232323123464818 no 773 0.258335052427142 1298 27211724
SGTC_3105 9121040 49.47 µM 0.648350049534564 0.232370782672611 no 774 0.258379284814048 1136 41448907
SGTC_2970 9090938 41.86 µM 0.646980624671139 0.232848123448864 no 775 0.258822241659048 1273 17217104
SGTC_1746 st038117 42 µM 0.646066925239714 0.233166914655915 no 776 0.259118007072646 1287 2898218
SGTC_3346 9158254 43.5805 µM 0.645857349709407 0.233240070042113 no 777 0.259185871508512 1247 17639500
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.645055005534257 0.233520257650847 no 778 0.259445770295501 1208 1241132 A phosphatase inhibitor.
SGTC_3142 9086498 49.47 µM 0.643973634183688 0.233898179852313 no 779 0.259796265620308 1222 25236367
SGTC_2774 tamoxifen 10.92 µM 0.643304670802712 0.234132141544961 no 780 0.260013213057274 1306 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2271 7849410 118.62 µM 0.641428195788933 0.234789106599668 no 781 0.260622259403178 1280 972430
SGTC_488 nitrendipine 139 µM 0.641210116288081 0.234865523570585 no 782 0.260693088933933 1313 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2571 chrysanthemic acid 100 µM 0.640461715231578 0.235127874371625 no 783 0.260936235672537 1222 2743 An insecticide.
SGTC_974 1326-0144 138 µM 0.640116033749388 0.235249107089959 no 784 0.261048582900132 1289 5411856
SGTC_360 0957-0399 1.01 µM 0.640082248906553 0.235260957502657 no 785 0.261059564380779 1290 6752301 YPR165W RHO1
SGTC_1451 4152-0210 104 µM 0.639720193454043 0.235387973204392 no 786 0.261177262385392 1304 659563
SGTC_2953 9074162 66.49 µM 0.638686072152118 0.23575097030524 no 787 0.261513587561976 1267 16451992
SGTC_1916 st067606 49.2 µM 0.637833361210886 0.236050520820026 no 788 0.261791080180472 1316 19590279
SGTC_808 0711-0032 135 µM 0.63689401162518 0.236380749409485 no 789 0.262096941842927 1266 4252555
SGTC_508 roscovitine 141 µM 0.636891093251909 0.236381775760505 no 790 0.262097892379887 1336 160355 A CDKinase inhibitor.
SGTC_919 tnp00227 403.569 nM 0.636017800584985 0.236689010744467 no 791 0.26238240996402 1310 1269246 A methoxyflavone. YNL221C POP1
SGTC_538 2922-0838 53.3 µM 0.635997842577762 0.2366960347806 no 792 0.262388914104166 1329 777039
SGTC_1175 0741-0056 27.6 µM 0.635962782819796 0.236708374015907 no 793 0.262400339972807 1340 765927
SGTC_1006 4099-6547 255 µM 0.635794561179756 0.236767584320313 no 794 0.262455166438019 1304 3146833
SGTC_2363 9053361 176 µM 0.634970771660554 0.237057657625941 no 795 0.262723738950598 1353 6469797 YMR079W SEC14
SGTC_746 1095-0025 46.6 µM 0.63196663352268 0.238117129528 no 796 0.263704340235508 1285 6749286
SGTC_2575 plumbagin 510 nM 0.630937537775581 0.23848065738011 no 797 0.264040683195019 1260 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1225 1216-0074 20.6 µM 0.63030452767434 0.238704418905896 no 798 0.264247680628185 1285 4241466
SGTC_3073 9114972 49.47 µM 0.630283338880985 0.238711910878249 no 799 0.264254610897483 1243 41905075
SGTC_3030 9087619 49.47 µM 0.629765037233073 0.238895212982476 no 800 0.264424161873645 1252 25236973
SGTC_57 miconazole 162.5 nM 0.628316638302156 0.239407860345643 no 801 0.264898267086902 1227 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3152 9099253 49.47 µM 0.628048868027106 0.239502700910186 no 802 0.264985963772799 1298 25236131
SGTC_3235 9132602 49.47 µM 0.622946123084096 0.241313937675206 no 803 0.266659963596808 1333 4912240
SGTC_1882 5615643 20 µM 0.622759327445544 0.241380382346114 no 804 0.266721344814312 1243 2253075
SGTC_222 nsc-310342 10.666 µM 0.622410302178462 0.241504559997392 no 805 0.266836053971389 1278 432556
SGTC_2482 5981709 142.65 µM 0.622181768508332 0.241585887442657 no 806 0.266911176375651 1316 877755
SGTC_3237 9133362 49.47 µM 0.622128727922267 0.241604764928894 no 807 0.266928613129795 1297 43845137
SGTC_568 1193-0097 7.48 µM 0.621096051927661 0.241972460509611 no 808 0.267268213390803 1215 3646150
SGTC_876 0720-0963 56.8 µM 0.620143547373655 0.242311879088777 no 809 0.267581642078831 1386 765861
SGTC_143 4032-1194 15.74 µM 0.619657348114208 0.242485232330415 no 810 0.267741700953928 1338 1806963
SGTC_1033 k072-0102 21.3 µM 0.618891954182914 0.242758267859321 no 811 0.26799376962361 1290 5965931
SGTC_376 3970-0862 59.1 µM 0.618675259403684 0.24283559862559 no 812 0.268065155833055 1307 3135186
SGTC_2306 7482397 179.52 µM 0.617435920076785 0.243278131397199 no 813 0.268473617792309 1384 891448
SGTC_1631 benzylvanillin 81.9 µM 0.615011471690758 0.244145091798687 no 814 0.269273572252282 1336 75506
SGTC_1710 st031758 61.5 µM 0.614543547067118 0.244312608927267 no 815 0.269428102984479 1367 5394341
SGTC_398 bronopol 33.3 µM 0.614116634357644 0.244465497809625 no 816 0.269569128424073 1285 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1142 3253-1408 9.78 µM 0.613084861385634 0.244835216102416 no 817 0.269910114769493 1312 256655
SGTC_2941 9056145 11.23 µM 0.612957418419291 0.244880903994529 no 818 0.269952247839749 1226 2119517
SGTC_2506 ethyl hematommate 54.16 µM 0.612493740881186 0.245047169602984 no 819 0.270105568951684 1281 3940691 An allergen.
SGTC_2886 9058944 51.95 µM 0.61218997720798 0.245156126170858 no 820 0.270206036040213 1219 4949929
SGTC_457 grayanotoxin iii 135 µM 0.611839659591437 0.245281813448065 no 821 0.27032192362371 1284 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1261 0712-0010 12.7 µM 0.611479708145544 0.245410993233168 no 822 0.270441024022988 1348 2840123
SGTC_1269 0831-0796 3.05 µM 0.610736254676048 0.245677920360629 no 823 0.270687100200032 1322 927758
SGTC_2247 cerulenin 830 nM 0.610537861868588 0.24574917701619 no 824 0.270752785266364 1376 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_67 0335-0847 266 µM 0.608770378199333 0.246384492824283 no 825 0.271338325249886 1491 4552207 YOR254C SEC63
SGTC_83 0170-0301 39.027 µM 0.608461929806035 0.24649545366272 no 826 0.271440574064264 1289 3089716
SGTC_626 0214-0009 33 µM 0.608239122039539 0.246575622902192 no 827 0.271514445457377 1398 3437874
SGTC_983 1491-0821 12.2 µM 0.608063576294574 0.246638796464942 no 828 0.27157265428952 1316 46495113
SGTC_2973 9094665 17.96 µM 0.607786134414563 0.246738657014749 no 829 0.27166466330989 1395 25237061 YIL048W NEO1
SGTC_784 4579-0127 173 µM 0.60622071493531 0.247302508944951 no 830 0.272184099476565 1447 1948547
SGTC_1426 4048-4480 71.7 µM 0.606101290348962 0.247345553015824 no 831 0.272223747098959 1359 14224343
SGTC_1499 4480-0877 67.3 µM 0.606093829158019 0.247348242377493 no 832 0.272226224225873 1282 2861909
SGTC_320 4092-0846 5.34 µM 0.603782810594288 0.248181993086704 no 833 0.272994024610322 1355 1359356
SGTC_2800 7887935 81.82 µM 0.603610060170672 0.248244376746981 no 834 0.273051461380163 1352 2961002
SGTC_129 0088-0017 176.636 µM 0.602784889947114 0.248542477671771 no 835 0.273325899977943 1274 182446
SGTC_1891 st059073 26.2 µM 0.600888297544759 0.249228362789568 no 836 0.273957194059886 1385 688754
SGTC_2190 6049624 200 µM 0.6003174224112 0.249435011412044 no 837 0.274147354866701 1293 2265554
SGTC_1271 0832-2808 169 µM 0.600208160273693 0.24947457312085 no 838 0.274183757957512 1366 3663794
SGTC_947 3447-0010 211 µM 0.596664474020855 0.250759479208034 no 839 0.27536570795859 1339 748350
SGTC_181 1447-1644 8.07 µM 0.59638546032674 0.250860795458226 no 840 0.275458875678606 1312 534600
SGTC_3089 9117425 49.47 µM 0.596291825520654 0.250894801252331 no 841 0.275490145509149 1267 9401657
SGTC_2764 methyldopa 94.69 µM 0.593685429416574 0.251842356819632 no 842 0.276361265120276 1406 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2003 4023581 200 µM 0.59279370696648 0.252166975802826 no 843 0.2766596098957 1377 16641307
SGTC_1907 st060210 83.7 µM 0.592781086399547 0.252171571725512 no 844 0.27666383350817 1393 688793
SGTC_3306 9127676 59.7925 µM 0.591440935326474 0.252659854260084 no 845 0.277112509641695 1351 41905287
SGTC_701 4424-0219 185 µM 0.591077296233763 0.252792431593016 no 846 0.2772343156477 1379 2911779
SGTC_1717 st033143 58.0435 µM 0.590857165639742 0.252872705683302 no 847 0.277308064195995 1423 674616
SGTC_433 pimozide 108 µM 0.588475435502083 0.253742098345162 no 848 0.278106608612285 1298 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2831 7999036 19.48 µM 0.588188233599903 0.253847040351011 no 849 0.278202977147593 1471 2988270
SGTC_918 glabranin 770.725 nM 0.586950226247346 0.254299662105154 no 850 0.278618567903948 1421 124049 Also referred to as licorice root.
SGTC_3109 9122853 49.47 µM 0.586697149243886 0.254392240395653 no 851 0.27870356135854 1431 1234709
SGTC_1892 st058411 7.36 µM 0.585744871900947 0.254740751911752 no 852 0.279023487520201 1414 3934738
SGTC_979 1426-2828 121 µM 0.585490855381537 0.25483375830903 no 853 0.279108856826559 1423 747872
SGTC_1703 st026983 48.3 µM 0.585390972755953 0.254870334511861 no 854 0.279142428635227 1399 1104023
SGTC_3 0833-0587 95.581 µM 0.584477825274161 0.255204849014758 no 855 0.279449439986361 1286 5382644
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.579989562755059 0.256852371342172 no 856 0.280960828138879 1391 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1002 4049-0206 172 µM 0.579892152558436 0.256888189315723 no 857 0.280993674030117 1357 4662749
SGTC_607 4491-0986 66.8 µM 0.579636661652861 0.256982146309505 no 858 0.281079832208943 1427 698981 YDR232W HEM1
SGTC_760 0568-0725 82.9 µM 0.579356709067315 0.257085119629714 no 859 0.281174254153716 1390 3916171
SGTC_2885 9057732 51.95 µM 0.579095000828505 0.257181401642013 no 860 0.281262536526618 1357 6471414
SGTC_196 k015-0023 18.111 µM 0.578750532052719 0.257308159686668 no 861 0.281378757012667 1363 5211998
SGTC_3328 9140624 29.0385 µM 0.57869757665843 0.257327649157115 no 862 0.281396625713815 1415 4904392
SGTC_2038 4100038 30.985 µM 0.578214787726076 0.257505368047452 no 863 0.281559558090549 1390 3596803
SGTC_3164 9100705 49.47 µM 0.577814427274843 0.25765279262461 no 864 0.28169470687634 1417 17174235
SGTC_1133 3473-0247 50 µM 0.575664522204557 0.258445200214872 no 865 0.282420979961313 1332 711311
SGTC_1824 st053723 68.6 µM 0.575547683823925 0.25848830040533 no 866 0.28246047566471 1331 675225
SGTC_2287 7945887 168.79 µM 0.574225532857498 0.258976284363184 no 867 0.282907596695867 1397 1245853
SGTC_2659 sanguinarine 24.21 µM 0.574177607493295 0.258993981763637 no 868 0.282923810332141 1330 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2416 tofa 880 nM 0.573929269111907 0.259085695700987 no 869 0.283007832868034 1301 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3055 9094636 49.47 µM 0.573655939396876 0.259186658606109 no 870 0.28310032478922 1423 25236176
SGTC_2347 9049783 174.81 µM 0.573430001828032 0.259270131086347 no 871 0.283176790652748 1418 6467988 YPL169C MEX67
SGTC_131 0141-0277 33.849 µM 0.572851621719017 0.259483876506522 no 872 0.283372581609515 1422 1547771
SGTC_1268 0828-0275 2.46 µM 0.57277015595957 0.259513990199771 no 873 0.283400164291512 1422 745337
SGTC_1627 st003713 25.6 µM 0.571124664257971 0.26012262983863 no 874 0.283957570356699 1400 16195070 YER133W GLC7
SGTC_3202 9113761 49.47 µM 0.570758894111002 0.260258021944053 no 875 0.284081545281747 1511 4798415
SGTC_3063 1327-0034 4 µM 0.570714852534533 0.260274326657859 no 876 0.284096474575178 1296 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1829 berberine 14.4 µM 0.569767867169341 0.260625039154091 no 877 0.284417576140688 1459 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_305 1682-2595 20.8 µM 0.569339075613037 0.260783920477505 no 878 0.284563026783054 1394 226033
SGTC_254 nsc-64875 3.808 µM 0.569092212569108 0.260875413923212 no 879 0.284646781454296 1499 56993
SGTC_2318 6029776 164 µM 0.568979468860202 0.260917204974204 no 880 0.284685036587489 1465 818325
SGTC_2186 6124449 200 µM 0.56828595139372 0.26117434889578 no 881 0.284920408365738 1392 3834182 YLR033W RSC58
SGTC_3218 9131285 49.47 µM 0.568056458027055 0.261259469617845 no 882 0.284998316185667 1489 17156417
SGTC_308 4092-1169 104 µM 0.567846761576949 0.261337259982893 no 883 0.285069512279808 1381 2268590 YDL196W YDL196W
SGTC_740 k014-0057 261 µM 0.567792947104701 0.261357225269318 no 884 0.285087784725132 1454 4012779
SGTC_183 3914-0051 30.55 µM 0.567062043025418 0.26162846983287 no 885 0.285336014965305 1445 1596232
SGTC_2702 st077768 96.8 µM 0.565422108198848 0.262237588545889 no 886 0.285893345301155 1337 6484119
SGTC_650 1328-0195 38 µM 0.56527204158769 0.262293363838923 no 887 0.285944371136432 1375 2780821
SGTC_1355 1499-0035 1.68 µM 0.565021297195648 0.262386571623266 no 888 0.286029639214055 1373 1548538
SGTC_2944 9067346 25.62 µM 0.564764835093879 0.262481922361514 no 889 0.286116864152306 1376 6473075
SGTC_3298 9116858 71.43 µM 0.563765114332335 0.262853780514731 no 890 0.286456998254851 1464 2506942
SGTC_3009 9080819 71.4286 µM 0.563713631238461 0.262872937561381 no 891 0.28647451949567 1369 17027216
SGTC_2013 4024628 200 µM 0.562892547063782 0.263178562429495 no 892 0.286754027769303 1412 5230760
SGTC_3214 9129694 49.47 µM 0.561485561966573 0.263702693701873 no 893 0.287233285066953 1441 17158655
SGTC_3339 9145883 14.936 µM 0.560883564997374 0.263927112645134 no 894 0.287438457304605 1374 2030670
SGTC_1713 st033146 12.748 µM 0.560740382239278 0.263980504190154 no 895 0.287487266966077 1470 674619
SGTC_693 4161-2696 114 µM 0.560328806465816 0.264134007690361 no 896 0.287627591114054 1464 805759
SGTC_543 3844-1095 191 µM 0.557774836318026 0.265087565503489 no 897 0.2884990739401 1457 4230703
SGTC_2761 levamisole 97.89 µM 0.556988291681605 0.265381583913744 no 898 0.288767714376876 1482 26879 An alkaline phosphatase inhibitor.
SGTC_365 0121-0052 13.6 µM 0.556933032389837 0.265402246621262 no 899 0.288786592342091 1423 3101739
SGTC_1688 st021091 57.6 µM 0.556553386211195 0.265544227041532 no 900 0.288916304739527 1423 3656366
SGTC_2157 5649910 96.377 µM 0.555174037466184 0.266060401213046 no 901 0.289387812670095 1357 2858091
SGTC_1763 st044482 94.5 µM 0.55510037712271 0.266087980368062 no 902 0.289413002425521 1433 88505
SGTC_2075 5212009 200 µM 0.55462851545598 0.266264684339185 no 903 0.289574390206604 1414 780898
SGTC_2553 4-methylesculetin 85.09 µM 0.553155964480836 0.266816510651515 no 904 0.29007830874782 1378 5319502
SGTC_1929 genistein trimethyl ether 50.5 µM 0.549947621983162 0.268020808337491 no 905 0.291177649766088 1491 136420
SGTC_1718 roemerine 11.9335 µM 0.548877869829018 0.268422962753774 no 906 0.291544633130998 1356 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1454 4239-0054 42.6 µM 0.548770148753025 0.268463475397473 no 907 0.2915815992883 1506 1340767
SGTC_296 1222-0039 74.9 µM 0.547140204603048 0.26907685337466 no 908 0.292141206416595 1358 5984176
SGTC_1529 apigenin 74 µM 0.546913152695254 0.269162352960025 no 909 0.292219199568891 1500 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1343 1487-0095 224 µM 0.546452817310962 0.26933574053591 no 910 0.292377356161972 1427 4560101 YGL055W OLE1
SGTC_2439 5492030 7.2 µM 0.54414607466172 0.270205429067735 no 911 0.2931704783301 1409 5722370
SGTC_1476 4112-3294 3.34 µM 0.542429781180759 0.270853416268491 no 912 0.293761234160555 1488 704369
SGTC_2586 curcumin 80 µM 0.541615454521937 0.271161136642416 no 913 0.29404172155221 1493 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2994 9053520 71.4286 µM 0.5410837617824 0.27136214842558 no 914 0.294224925046296 1492 4647384
SGTC_1496 4469-0713 57.4 µM 0.540623960806835 0.271536040656056 no 915 0.294383399553882 1466 746691
SGTC_1495 4469-0029 237 µM 0.540506218436927 0.271580578592021 no 916 0.294423986849022 1404 793680
SGTC_1453 4237-0541 195 µM 0.539604640606212 0.271921735363631 no 917 0.294734857801705 1428 739892
SGTC_1758 st042942 75.2445 µM 0.537578188368819 0.272689321507635 no 918 0.295434145935742 1397 669317
SGTC_1784 st039334 36.3 µM 0.535705438850493 0.27339964235072 no 919 0.296081072059557 1510 3496984
SGTC_2319 6033012 152.6 µM 0.535681301566877 0.273408803430974 no 920 0.296089414330348 1380 847246
SGTC_3174 9107204 49.47 µM 0.535010408594648 0.273663495389993 no 921 0.29632132992296 1465 3938802
SGTC_1477 0139-0234 16 µM 0.534261202006493 0.273948056309084 no 922 0.296580415518563 1450 620880
SGTC_3157 9099274 49.47 µM 0.532970770712987 0.274438525873904 no 923 0.29702690693867 1405 17217662
SGTC_1059 3448-6867 171 µM 0.532791929901842 0.274506534204805 no 924 0.29708881041175 1430 3934407
SGTC_2763 lisinopril 49.32 µM 0.532067964548492 0.274781923614799 no 925 0.297339462071018 1411 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2438 5259590 200 µM 0.531850722545391 0.274864586928299 no 926 0.297414694550642 1500 1201127
SGTC_2703 st077852 53.4 µM 0.530645644209306 0.275323356828525 no 927 0.29783217969455 1450 6281836
SGTC_1385 3091-4834 14.1 µM 0.529680379755722 0.27569110188027 no 928 0.298166776800157 1480 4072814
SGTC_367 0335-0881 7.1 µM 0.528759468044931 0.276042174408629 no 929 0.298486159077454 1506 23828853
SGTC_1967 st070177 51.4 µM 0.526449268285658 0.276923840085937 no 930 0.299288045834592 1505 5729214
SGTC_928 2764-0428 58.7 µM 0.524940509685594 0.27750038673353 no 931 0.299812273629271 1500 662578
SGTC_1010 4112-3296 15.2 µM 0.524715315999066 0.277586490991823 no 932 0.299890554256657 1519 704384
SGTC_567 1080-0542 68.4 µM 0.523763315048647 0.277950638867142 no 933 0.300221585924013 1444 5950415
SGTC_32 0928-0142 34.1 µM 0.523677061250216 0.277983643140214 no 934 0.300251586426874 1424 2244242
SGTC_3277 9138724 49.47 µM 0.522191789123292 0.278552269526732 no 935 0.300768401169282 1425 15943418
SGTC_743 1275-0778 158 µM 0.52188556089798 0.278669577339057 no 936 0.300875006117921 1525 2849257 YMR203W TOM40
SGTC_1632 st005650 90 µM 0.521474731933187 0.278826992658433 no 937 0.301018051703241 1465 2759605
SGTC_695 3505-6186 243 µM 0.521130681912549 0.27895885390287 no 938 0.301137869264457 1488 1819379
SGTC_101 0490-5701 117.494 µM 0.519922313609637 0.279422215579491 no 939 0.301558861219167 1438 4661669
SGTC_2227 7312221 64.1025 µM 0.518923021786563 0.279805686848171 no 940 0.301907211432447 1464 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1004 4084-0029 199 µM 0.51863988704224 0.279914384228027 no 941 0.302005944239054 1504 716894 YLR208W SEC13
SGTC_3312 9133330 71.43 µM 0.518460941215106 0.279983093323444 no 942 0.302068352479067 1521 17617324
SGTC_978 1416-0512 87.4 µM 0.517737409076348 0.280260988332132 no 943 0.30232074690332 1485 6814003
SGTC_1298 1079-1278 263 µM 0.517022995340699 0.280535512158634 no 944 0.302570053280516 1470 2840950
SGTC_1418 3966-3099 2.4 µM 0.516070814794452 0.280901603515723 no 945 0.302902475448938 1519 740335
SGTC_1739 st037196 92.5 µM 0.513658430232971 0.281830141803563 no 946 0.303745410138134 1538 612214
SGTC_2678 equilin 100 µM 0.513654930013336 0.281831490128664 no 947 0.303746633944035 1548 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2958 9077254 16.72 µM 0.511457595274894 0.282678541815188 no 948 0.304515337021384 1462 16457351
SGTC_3260 9137109 49.47 µM 0.510508189509846 0.283044906847559 no 949 0.304847739313725 1501 17478346
SGTC_3091 9116372 49.47 µM 0.50891850129096 0.283658859490965 no 950 0.305404675534708 1463 17169793
SGTC_1113 artemisinin 1.17947 µM 0.508232061995138 0.28392416589877 no 951 0.305645304176436 1513 2240 An anti-malaria and mitochondrial poison.
SGTC_675 1309-0189 238 µM 0.508226327625606 0.283926382712791 no 952 0.305647314691261 1430 4246530
SGTC_792 4534-1957 155 µM 0.506171328994421 0.284721344657335 no 953 0.306368190209777 1487 1717904
SGTC_1830 st055982 50.3 µM 0.504059518993715 0.285539388891788 no 954 0.30710977626586 1502 455313 An antimicrobial agent.
SGTC_749 1000-0129 128 µM 0.502723591360557 0.286057459423618 no 955 0.307579310432406 1594 708470
SGTC_1772 st048439 82.2 µM 0.502162713384449 0.28627510002189 no 956 0.307776534457683 1452 2927068 YDL195W SEC31
SGTC_843 0310-0051 143 µM 0.49984392501138 0.287175705790647 no 957 0.308592489461713 1488 2065037
SGTC_2526 patulin 37.61 µM 0.499568488561919 0.287282772981362 no 958 0.308689475326728 1530 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1976 st070609 63.5 µM 0.498886091797556 0.287548114436756 no 959 0.308929816330324 1446 682556
SGTC_103 0844-0104 51.839 µM 0.497663855170057 0.288023655279357 no 960 0.309360494112745 1525 5375804
SGTC_2847 9005661 71.43 µM 0.497113859111555 0.288237765639709 no 961 0.309554380960818 1439 2991449
SGTC_1866 st057638 64 µM 0.497086260830689 0.288248511472407 no 962 0.309564111416378 1492 688802
SGTC_2300 7976697 71.57 µM 0.496974502632309 0.28829202824868 no 963 0.309603515894218 1414 2236109
SGTC_1202 1988-0068 29.6 µM 0.496764308252354 0.288373882822493 no 964 0.309677633610052 1426 2850480
SGTC_3080 9117754 49.47 µM 0.49603890842025 0.28865645448873 no 965 0.309933479985204 1600 9550191
SGTC_1867 st057372 64 µM 0.495652148108004 0.288807166071951 no 966 0.310069926843336 1468 688837
SGTC_480 am 92016 50 µM 0.495332799593681 0.28893163674456 no 967 0.31018261091708 1427 2129 K+ channel blocker.
SGTC_2860 9025725 38.96 µM 0.494606383456015 0.289214861847776 no 968 0.310438997666638 1441 40546248
SGTC_3047 9092122 49.47 µM 0.493940820434833 0.28947447521692 no 969 0.310673987343963 1450 17173831
SGTC_2328 6201408 200 µM 0.49333231501507 0.289711928105788 no 970 0.310888899365832 1464 2890418
SGTC_1089 terbinafine 2.25 µM 0.4933124236091 0.289719691735095 no 971 0.310895925704568 1543 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2132 5317594 122.667 µM 0.49048946978706 0.29082248132877 no 972 0.311893789724816 1532 794577
SGTC_450 aminopyrene 156 nM 0.49030863928834 0.290893189763369 no 973 0.311957757277837 1536 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_3095 9117207 49.47 µM 0.488230502570704 0.291706360012875 no 974 0.312693290667174 1524 17015229
SGTC_3251 9135047 49.47 µM 0.487817038220845 0.291868273962856 no 975 0.312839720909917 1580 17682963
SGTC_63 0099-0242 26.702 µM 0.487411517877542 0.292027117666362 no 976 0.312983366438852 1491 3898502 YLR359W ADE13
SGTC_766 1391-0721 126 µM 0.48701075695074 0.292184136618139 no 977 0.313125353959714 1604 1020919 YIL115C NUP159
SGTC_1487 3970-0795 2.82 µM 0.485010551358188 0.292968407942422 no 978 0.313834430454657 1546 3765103
SGTC_3069 9117009 49.47 µM 0.484684197216703 0.293096462518114 no 979 0.313950188950739 1449 41904981
SGTC_2149 5554786 194.827 µM 0.484453047896271 0.293187176404642 no 980 0.314032189176512 1507 745063 YPR165W RHO1
SGTC_2965 9082772 38.63 µM 0.484201904023987 0.293285751848418 no 981 0.314121292878658 1604 16459634
SGTC_218 alverine citrate 93.75 µM 0.484171091597643 0.293297846964478 no 982 0.314132225610882 1561 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_366 0181-0206 4.31 µM 0.483401640370622 0.293599962445834 no 983 0.31440529184799 1658 274874
SGTC_187 1488-2104 32.728 µM 0.482909752359879 0.293793171634742 no 984 0.314579908465871 1589 2852859
SGTC_333 3486-0131 40.1 µM 0.482280253193241 0.294040519026486 no 985 0.314803436539538 1608 6744690
SGTC_3354 9151612 71.43 µM 0.480621004046637 0.294692944094951 no 986 0.315392942294557 1588 27261949
SGTC_522 1273-0010 11.6 µM 0.479198412814208 0.295252845109569 no 987 0.31589874163841 1551 5705015
SGTC_603 3794-0023 45.9 µM 0.478441714097581 0.295550864645932 no 988 0.316167924868241 1599 3802260
SGTC_43 0570-0105 72.5 µM 0.478384394453966 0.295573445148175 no 989 0.316188319369674 1559 1114046 YDL195W SEC31
SGTC_2006 4011487 200 µM 0.476765440443028 0.296211543244439 no 990 0.316764578840262 1636 45595294
SGTC_1796 st049173 110.4 µM 0.475353802039308 0.296768444669854 no 991 0.317267408426698 1526 94134
SGTC_1443 4112-3303 14 µM 0.473894256127001 0.297344749424657 no 992 0.317787657696071 1515 704433
SGTC_2207 7258803 200 µM 0.473859008740125 0.297358673249725 no 993 0.317800225940266 1552 3666799
SGTC_1944 st076371 56.9 µM 0.473698331588224 0.297422149545572 no 994 0.317857521632164 1474 24208455
SGTC_1877 wortmannin 25 µM 0.473299565774799 0.297579710665115 no 995 0.31799973594217 1570 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2378 9074213 121.43 µM 0.472660823355852 0.297832171165821 no 996 0.318227590516654 1492 657714
SGTC_1098 clofazimine 15.1 µM 0.471877025610194 0.298142097628215 no 997 0.318507283772546 1566 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1352 1496-0991 99 µM 0.471780870568135 0.29818012902142 no 998 0.318541603217387 1526 3000039
SGTC_2065 5221596 34.26 µM 0.470567251012256 0.298660331557259 no 999 0.318974899375927 1561 788581
SGTC_930 2810-3379 265 µM 0.470302499982105 0.29876513441267 no 1000 0.319069455811113 1669 1015764
SGTC_2750 bromebric acid 70.15 µM 0.469992878367514 0.298887720685717 no 1001 0.319180052814295 1576 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2682 pyrogallin 40.03 µM 0.467346212721528 0.299936527274746 no 1002 0.320126099149042 1543 822798 An ATP competetive kinase inhibitor.
SGTC_1132 3456-3614 2.5 µM 0.467028524440474 0.30006253098297 no 1003 0.320239735119622 1734 3125502
SGTC_2532 xanthone 78.9 µM 0.466858137997994 0.300130120688086 no 1004 0.320300688692674 1594 7020 An insecticide.
SGTC_1182 1222-0449 220 µM 0.46661858674342 0.300225158663475 no 1005 0.320386393294064 1555 658318
SGTC_503 tyrphostin 8 294 µM 0.466007891235023 0.300467503479278 no 1006 0.320604926051205 1600 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_440 fluspirilene 35.1 µM 0.46594027273505 0.300494342240021 no 1007 0.320629126644712 1615 3396 An atypical antipsychotic.
SGTC_932 2857-0803 154 µM 0.46382612678901 0.3013340228785 no 1008 0.321386161523966 1642 674898
SGTC_960 1222-0186 7.7 µM 0.463800595324106 0.301344169727796 no 1009 0.321395308393187 1619 3126296
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.463065848077656 0.301636242738884 no 1010 0.321658584372064 1642 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1748 st037455 53.6035 µM 0.463045897089185 0.301644175330222 no 1011 0.321665734496682 1581 580690
SGTC_3188 9110789 49.47 µM 0.462990797853146 0.301666083490117 no 1012 0.321685481550822 1603 849217
SGTC_1643 st009866 20.2 µM 0.462931701741287 0.301689581654146 no 1013 0.321706661608011 1585 3156273 YOR207C RET1
SGTC_1346 1488-2224 62.4 µM 0.461658046520401 0.302196220261521 no 1014 0.32216328059223 1585 3722427
SGTC_1565 sinapyl alcohol 95.1 µM 0.461462962397691 0.302273855154393 no 1015 0.322233244064418 1461 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2908 7930301 100 µM 0.459197619639343 0.303176016332615 no 1016 0.323046129890631 1443 2223178
SGTC_46 0329-0187a 2.197 µM 0.458994207696357 0.303257082981913 no 1017 0.323119162798705 1621 46494817
SGTC_574 1315-0397 40 µM 0.458958250574114 0.303271414138601 no 1018 0.323132073532688 1522 6794277
SGTC_2896 9052656 71.43 µM 0.458766738503087 0.303347748747797 no 1019 0.323200841284532 1510 6469436
SGTC_542 3381-0244 89.3 µM 0.458191677111618 0.303577013490263 no 1020 0.32340736942298 1647 1112843
SGTC_2206 7254556 146.969 µM 0.457674206018558 0.303783384316229 no 1021 0.32359326104624 1595 4398905
SGTC_781 4335-2806 94.4 µM 0.456672074680971 0.304183218661018 no 1022 0.323953382786639 1669 845254
SGTC_362 0310-0100 9.03 µM 0.455570211811571 0.304623114686358 no 1023 0.324349533893761 1547 790235
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.454806271018825 0.304928268278767 no 1024 0.324624309165447 1630 94937 An inhibitor of serotonin biosynthesis.
SGTC_385 1494-0393 12.4 µM 0.454010108452372 0.305246437183938 no 1025 0.32491077561896 1575 3090647
SGTC_1047 2043-3044 82 µM 0.452111915749099 0.306005601836239 no 1026 0.325594179972999 1490 669592
SGTC_690 glyoxal 20.3 µM 0.44844615737765 0.307474046873484 no 1027 0.326915618123659 1472 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_845 0330-0138 4.51 µM 0.448414501525036 0.307486741203091 no 1028 0.326927038962267 1643 9039800
SGTC_2739 tacrine 100.86 µM 0.44790830607689 0.307689762211922 no 1029 0.327109686814125 1554 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_632 0781-2353 4.65 µM 0.447739912997737 0.307757313083628 no 1030 0.32717045638913 1587 6811515 YHR007C ERG11
SGTC_444 curcumin 90.4 µM 0.447169032267319 0.307986370335277 no 1031 0.327376509511845 1570 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_3259 9138485 49.47 µM 0.446971510655417 0.308065640320265 no 1032 0.327447815018555 1645 17646153
SGTC_121 0557-0495 61.343 µM 0.446901320022344 0.308093811599191 no 1033 0.32747315542608 1591 3104427
SGTC_352 k048-0007 5.11 µM 0.446301560708926 0.308334573386651 no 1034 0.327689714520137 1545 6811911
SGTC_2336 9001819 198.65 µM 0.445010287837057 0.308853209737104 no 1035 0.328156159720175 1651 2989602
SGTC_570 0987-0065 62.6 µM 0.444061240610976 0.309234635297709 no 1036 0.32849915407036 1547 3104428
SGTC_2429 5902844 64.44 µM 0.443838119067687 0.309324338542537 no 1037 0.328579813237688 1675 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2156 5649887 115 µM 0.443752334061946 0.309358830363628 no 1038 0.328610826923906 1647 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_3101 9120531 49.47 µM 0.443697851513587 0.309380737188944 no 1039 0.328630524506643 1635 24824904
SGTC_2201 6605497 169.863 µM 0.442370815992389 0.309914532448539 no 1040 0.32911044694275 1622 670741
SGTC_2647 atorvastatin 60.16 µM 0.442302184993824 0.309942149934781 no 1041 0.329135275015621 1625 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2101 5377231 179.231 µM 0.441272862225819 0.31035648359527 no 1042 0.329507735027515 1654 2844213
SGTC_1227 3909-8010 46.6 µM 0.441198824235306 0.310386295422765 no 1043 0.329534532170551 1576 15982272
SGTC_495 decylubiquinone 155 µM 0.441068103622677 0.310438933879052 no 1044 0.329581847030851 1516 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1100 amiodarone 5.07 µM 0.440544677155213 0.310649745657191 no 1045 0.329771330706758 1672 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_3284 9108171 64.8615 µM 0.439889455056223 0.310913726217785 no 1046 0.330008586814322 1585 8687505
SGTC_3246 9135460 32.98 µM 0.439867499101402 0.310922573675949 no 1047 0.330016538256533 1609 41446951
SGTC_185 k048-0037 25.491 µM 0.439503869212723 0.311069119302197 no 1048 0.330148239529313 1656 6827589
SGTC_1524 corynanthine 62.1 µM 0.436563508091521 0.312255206301045 no 1049 0.331213966133123 1620 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_3315 9136395 68.55 µM 0.436395870616353 0.312322886960014 no 1050 0.331274767238427 1655 16876844
SGTC_1216 1165-0504 9.65 µM 0.434417054618276 0.313122276906275 no 1051 0.331992807688625 1659 6304004
SGTC_500 h-89 112 µM 0.43408801420605 0.313255285978564 no 1052 0.332112264441835 1716 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_901 1112-0062 60.1 µM 0.431992786305495 0.31410281611283 no 1053 0.332873328045611 1590 1908457
SGTC_459 nigericin 15.3 µM 0.43104884219256 0.314484967141586 no 1054 0.333216428506102 1604 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2032 5185112 25.99 µM 0.430914255236781 0.314539470201418 no 1055 0.333265358932515 1591 5718189
SGTC_372 0155-0182 15.9 µM 0.430826949236242 0.314574828272013 no 1056 0.333297101414955 1652 771486
SGTC_1267 0828-0272 9.49 µM 0.430161101773719 0.314844545862203 no 1057 0.333539227719063 1701 745334
SGTC_1828 st055811 49 µM 0.429181440745486 0.315241560794259 no 1058 0.333895594097942 1670 5877589
SGTC_2995 9067767 71.4286 µM 0.42852180811046 0.315509002126798 no 1059 0.334135629797531 1604 11673567
SGTC_295 k015-0027 31 µM 0.427173931670525 0.316055785364913 no 1060 0.334626323510465 1568 3887424
SGTC_1358 1509-0022 2.48 µM 0.427168130057653 0.316058139734036 no 1061 0.334628436195955 1579 3258434
SGTC_734 2023-0417 80 µM 0.42707128728479 0.316097440878306 no 1062 0.334663702734888 1628 3935732
SGTC_2460 5552655 174.22 µM 0.426848349263462 0.316187922428416 no 1063 0.33474489402067 1529 5401989
SGTC_2120 5538279 151.968 µM 0.425460432323664 0.316751469356101 no 1064 0.335250529956715 1615 2058197
SGTC_2104 5389443 200 µM 0.423892234971681 0.317388729004704 no 1065 0.335822203696611 1676 2244536
SGTC_29 0299-0004 12.984 µM 0.423780774007091 0.317434043417338 no 1066 0.335862850378704 1548 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2642 cholecalciferol 100 µM 0.422216706192937 0.31807020291996 no 1067 0.336433424278266 1641 9821465 A vitamin D precursor, similar to steriods.
SGTC_1729 st035615 45.989 µM 0.422086021930258 0.318123380988342 no 1068 0.336481115139184 1569 17385451
SGTC_643 k048-0106 28.4 µM 0.422033599955533 0.318144713603363 no 1069 0.336500246331205 1666 6763920
SGTC_1617 st002906 78 µM 0.421357541181515 0.318419883212161 no 1070 0.336747009214798 1582 5150859
SGTC_2280 7785178 200 µM 0.418413316208018 0.31961940920133 no 1071 0.337822476120583 1610 2954328
SGTC_357 1325-0123 420 µM 0.4176538094996 0.319929151893827 no 1072 0.338100124244817 1689 1098503
SGTC_383 2324-0395 7.37 µM 0.416579234914742 0.320367600347002 no 1073 0.338493100211973 1661 3146421
SGTC_2125 5246583 200 µM 0.41606856573042 0.320576051816297 no 1074 0.33867991555426 1757 835267
SGTC_3126 9127922 49.47 µM 0.415111310716381 0.320966948853208 no 1075 0.339030209891683 1623 45595682
SGTC_1292 0kpi-0043 232 µM 0.414903126967699 0.321051987407897 no 1076 0.33910641031868 1585 3333905
SGTC_2583 asiatic acid 100 µM 0.414788094732084 0.321098979612385 no 1077 0.339148517799841 1621 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_98 0074-0023 107.663 µM 0.413979598841053 0.321429341782141 no 1078 0.339444523897642 1550 3563821
SGTC_2555 cholic acid 100 µM 0.413707703336194 0.321540473664377 no 1079 0.33954409241259 1637 6708657 Influences liver metabolism.
SGTC_1807 st050092 58.9 µM 0.412061126645579 0.322213820132152 no 1080 0.340147310186149 1576 5008496
SGTC_3150 9097574 49.47 µM 0.411648277966323 0.32238274095429 no 1081 0.340298620145643 1736 17217476
SGTC_2902 5787006 60.46 µM 0.4111691740986 0.322578816676825 no 1082 0.340474245016661 1583 591003
SGTC_712 r015-0009 80.6 µM 0.411090319036922 0.322611093247767 no 1083 0.340503154195091 1672 6813872 YLR060W FRS1
SGTC_880 0833-0487 87.2 µM 0.409601337101349 0.323220806806462 no 1084 0.341049207959963 1587 76075
SGTC_1740 st038286 13.222 µM 0.409389409468089 0.32330762634531 no 1085 0.341126955203592 1643 716786
SGTC_1922 5578187 25 µM 0.408913450742224 0.323502645506778 no 1086 0.341301588818944 1712 1350412
SGTC_1573 oleylamine 1.06 µM 0.407600894968334 0.324040702772266 no 1087 0.34178335357423 1587 5356789 An amine of the fatty acid oleic acid.
SGTC_1885 st057546 99.9 µM 0.405389691411225 0.324947974914863 no 1088 0.342595543594008 1697 702008
SGTC_1386 3228-0095 33.8 µM 0.405237159621642 0.325010598138902 no 1089 0.342651596444818 1704 870181
SGTC_587 k089-0003 57 µM 0.40519724349323 0.325026986861339 no 1090 0.3426662655184 1644 9659696
SGTC_2334 9017922 200 µM 0.405087260453327 0.325072145334867 no 1091 0.342706685227515 1766 3163164
SGTC_3118 9124250 49.47 µM 0.404758083310649 0.325207319139174 no 1092 0.342827671405964 1586 1504786
SGTC_2279 7948423 32.93 µM 0.403224232825568 0.325837484944036 no 1093 0.343391637124375 1790 1247112
SGTC_1373 2887-0003 58.5 µM 0.402739063530657 0.32603691521456 no 1094 0.343570096724523 1607 776948
SGTC_3347 9188721 44.724 µM 0.402317490976253 0.326210244272657 no 1095 0.343725191882355 1652 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_3045 9092950 49.47 µM 0.4012273485951 0.326658629030559 no 1096 0.344126373596933 1743 44120432
SGTC_197 4544-0043 41.561 µM 0.400761698910614 0.326850231064609 no 1097 0.344297790180753 1616 896523
SGTC_1778 st046819 58.9 µM 0.397961485500162 0.32800340331454 no 1098 0.345329288045848 1616 671715
SGTC_1057 3448-5381 134 µM 0.397598967005449 0.328152814419695 no 1099 0.345462911045702 1726 5497911
SGTC_1855 st056195 39.6 µM 0.397362838174023 0.328250149126891 no 1100 0.345549957634855 1725 4028379
SGTC_2687 chenodiol 100 µM 0.396816002459105 0.328475605136782 no 1101 0.345751574637547 1676 5702181 A cholesterol synthesis inhibitor.
SGTC_415 dibenzyl ketone 100 µM 0.396103175551183 0.328769591775034 no 1102 0.346014457875422 1735 7593
SGTC_3006 9075424 71.4286 µM 0.395470986319536 0.329030410225448 no 1103 0.346247664885065 1573 7465181
SGTC_1899 st063254 59.6 µM 0.394636400752684 0.329374857591257 no 1104 0.346555622760771 1567 3093813
SGTC_71 0417-1750 47.813 µM 0.393258267153226 0.329943953257659 no 1105 0.347064369103281 1777 6811472
SGTC_3225 9130819 49.47 µM 0.392569104681119 0.330228688391358 no 1106 0.347318881086332 1675 4547121
SGTC_810 3825-7150 143 µM 0.391348684433394 0.330733159780823 no 1107 0.347769758760613 1803 22330411 YGL099W LSG1
SGTC_2073 5212005 126 µM 0.390437227441487 0.331110119216852 no 1108 0.348106632161621 1693 691789
SGTC_961 1252-1571 372 µM 0.389806501611372 0.331371074429241 no 1109 0.348339817874171 1755 6813498
SGTC_2216 7189485 200 µM 0.38804167898941 0.332101683359325 no 1110 0.348992595056493 1716 731273
SGTC_2098 5376439 882.5 nM 0.385862501780564 0.33300470972773 no 1111 0.349799251611939 1770 2844116
SGTC_1005 4092-0690 4.4 µM 0.385109618717023 0.333316921503375 no 1112 0.35007810094665 1615 1529343
SGTC_763 3453-1109 128 µM 0.384651511724841 0.333506949646349 no 1113 0.350247812066875 1765 1560353
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.38220238647144 0.334523599314098 no 1114 0.351155625912111 1625 279621
SGTC_2643 anethole 100 µM 0.38189627388605 0.334650754412939 no 1115 0.351269152104303 1658 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2430 5571206 200 µM 0.380122236436302 0.335388039041092 no 1116 0.351927340102082 1795 1731771
SGTC_1928 4'-methoxychalcone 40.3 µM 0.37997237713947 0.335450349212704 no 1117 0.351982959961489 1829 641818
SGTC_552 k242-0005 476 µM 0.379661733165068 0.335579526646949 no 1118 0.352098264690957 1659 4088318
SGTC_283 0987-0079 11.7 µM 0.379625570312274 0.335594565782885 no 1119 0.352111688490832 1752 411556
SGTC_1591 genipin 88.4 µM 0.378158879741459 0.336204743779441 no 1120 0.352656285212397 1717 442424 A DNA cross-linking agent.
SGTC_2545 solidagenone 89.61 µM 0.377333546990853 0.336548291700667 no 1121 0.352962872339838 1638 6708572 An anti ulcer agent
SGTC_1975 st070967 30.8 µM 0.37705125364933 0.336665828724942 no 1122 0.353067758037023 1774 261391
SGTC_3183 9108214 49.47 µM 0.376186812225276 0.337025850956268 no 1123 0.353389009451068 1670 4974831
SGTC_2667 digitoxin 100 µM 0.375897674387731 0.33714630431734 no 1124 0.353496484756081 1748 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1379 2144-0755 36.5 µM 0.375711316758441 0.337223948813508 no 1125 0.353565761864226 1790 5392327
SGTC_1157 4092-0394 27.6 µM 0.375021551908434 0.337511394423018 no 1126 0.353822219172728 1743 3659885
SGTC_1014 4130-3005 69.3 µM 0.374140408747181 0.337878731034574 no 1127 0.354149928197444 1628 743608
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.373917026440625 0.337971880638605 no 1128 0.354233024267332 1898 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1208 2323-2347 50.3 µM 0.373659426977037 0.338079310990293 no 1129 0.354328857407611 1779 5412760
SGTC_2786 7743617 45.45 µM 0.373388683826587 0.338192237053613 no 1130 0.354429590255425 1560 583674
SGTC_1357 1503-1303 39.5 µM 0.372950637835865 0.338374975401453 no 1131 0.354592591456371 1653 292895
SGTC_2370 9071495 200 µM 0.372592849725259 0.338524261057454 no 1132 0.354725747675263 1625 21791103
SGTC_2980 9014342 25.29 µM 0.370296888968336 0.339482844577714 no 1133 0.355580645789615 1676 2996599
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.370126588570867 0.339553987954342 no 1134 0.35564408594468 1782 23847180
SGTC_134 0269-0018 6.916 µM 0.368768180119563 0.340121670673135 no 1135 0.356150262105471 1622 4378915
SGTC_2751 anetholtrithion 17.25 µM 0.368754577581531 0.340127357047924 no 1136 0.356155332027227 1785 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_226 1,3-diallylurea 8.28947 mM 0.367396833164515 0.34069512828102 no 1137 0.356661516727465 1700 74537 YKL182W FAS1
SGTC_179 1273-0063 6.77 µM 0.366123500132277 0.341227929202832 no 1138 0.35713646128435 1622 3108139
SGTC_1445 4239-0156 97.7 µM 0.361994385543365 0.342957849102476 no 1139 0.358678113012436 1806 4008346
SGTC_1322 1348-1070 12 µM 0.361352505077506 0.343227066208863 no 1140 0.358917974040875 1720 6758089
SGTC_2843 9000894 45.46 µM 0.360253495473251 0.343688196854713 no 1141 0.359328786461976 1640 2242070
SGTC_2840 9008771 71.43 µM 0.360214888829019 0.343704399952787 no 1142 0.359343220678307 1833 2992978
SGTC_2977 9011197 71.43 µM 0.358233694465629 0.344536286407528 no 1143 0.360084216831685 1745 2704722
SGTC_2695 st077686 51.995 µM 0.356040813469629 0.345457935612456 no 1144 0.360905000243518 1639 2876092
SGTC_1859 st055998 20 µM 0.355211053191761 0.345806916231152 no 1145 0.361215742364969 1832 676301
SGTC_502 l-744,832 89.3 µM 0.35465544586671 0.346040666859932 no 1146 0.361423866445858 1810 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2646 retinol 96.75 µM 0.353776922906183 0.346410391664935 no 1147 0.361753034666612 1706 445354 A vitamin A analog and teratogen.
SGTC_3166 9102297 49.47 µM 0.352801327615216 0.346821140727617 no 1148 0.362118694201747 1652 25237072
SGTC_2607 solasodine 47.35 µM 0.35216579377707 0.347088812653 no 1149 0.362356964195322 1653 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2986 9022445 71.43 µM 0.351538160560589 0.347353231917872 no 1150 0.362592324485827 1827 6459286
SGTC_1690 st023502 41.2 µM 0.350384997320728 0.347839248410614 no 1151 0.363024892032685 1805 24207482
SGTC_3156 9099931 49.47 µM 0.349787664291183 0.348091101015869 no 1152 0.36324902870959 1718 18111053
SGTC_1611 st001856 99.4 µM 0.349510994057701 0.348207775776355 no 1153 0.363352859280151 1662 647478
SGTC_1677 st019204 53.9 µM 0.349489266793119 0.348216939001984 no 1154 0.363361013651949 1633 3945625
SGTC_2533 agelasine 13.65 µM 0.348543087792755 0.348616065067271 no 1155 0.36371618028113 1864 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1861 st057647 17.4 µM 0.346672884727224 0.349405464370436 no 1156 0.364418541604847 1840 688668
SGTC_1711 st032263 62.8 µM 0.345985644004936 0.349695707703088 no 1157 0.364676751834566 1746 3958979
SGTC_2813 7971799 71.43 µM 0.344045000001381 0.350515776526451 no 1158 0.365406222167826 1727 2234054
SGTC_2621 lithochol-11-enic acid 100 µM 0.343674340021811 0.350672487808681 no 1159 0.365545605353345 1855 6708711
SGTC_2780 5215298 71.43 µM 0.342653578568227 0.35110418669471 no 1160 0.365929544791842 1865 2834131
SGTC_935 2996-0153 430 µM 0.342447996200826 0.351191154551182 no 1161 0.366006886835681 1862 23738523
SGTC_3252 9135871 49.47 µM 0.342252160058582 0.351274006693707 no 1162 0.366080567320944 1769 17682838
SGTC_2827 7993847 71.43 µM 0.342124448678921 0.351328041189457 no 1163 0.366128619520939 1731 2985692
SGTC_2915 7971052 15.16 µM 0.341549392176016 0.351571383961114 no 1164 0.366345014104398 1751 5741558
SGTC_1464 k208-0027 110 µM 0.341012764170542 0.351798520084375 no 1165 0.366546986331077 1819 X1464
SGTC_290 2043-6722 48.1 µM 0.340969178693254 0.351816970637481 no 1166 0.366563392346318 1737 773758 YLR208W SEC13
SGTC_2742 clothiapine 36.27 µM 0.340910445061076 0.351841834241728 no 1167 0.366585500666179 1815 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1547 harmine 94.2 µM 0.340064749287311 0.352199911330029 no 1168 0.366903883719478 1709 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1516 st013856 110 µM 0.33988916209153 0.35227427336329 no 1169 0.366969999341757 1716 5281404 A mutagen and neurotoxin.
SGTC_1878 temozolomide 1 mM 0.338980125233973 0.352659345158675 no 1170 0.367312351235926 1852 5394 DNA alkylating agent.
SGTC_3344 9148862 3.898 µM 0.338798652876684 0.352736235700192 no 1171 0.367380708087268 1814 4905352
SGTC_1822 st052468 42 µM 0.338712384837365 0.352772789912897 no 1172 0.36741320493206 1703 2873678
SGTC_195 4234-0266 16.654 µM 0.337561134742639 0.353260737182789 no 1173 0.367846967303791 1721 2303354
SGTC_3058 9093861 49.47 µM 0.337491098102837 0.353290429394235 no 1174 0.367873360811448 1744 17217477
SGTC_2456 5770359 74.46 µM 0.337288683891945 0.353376248432995 no 1175 0.367949644691311 1804 3118787
SGTC_1908 st060353 56.5 µM 0.337181386328951 0.353421743192111 no 1176 0.367990084055399 1898 4227716
SGTC_2737 bleomycin 30.5 nM 0.335888900363115 0.353969928769343 no 1177 0.368477323756749 1722 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1179 1021-1431 9.29 µM 0.335599648593125 0.354092651418036 no 1178 0.368586394516112 1745 2840958
SGTC_1276 0871-0068 94.2 µM 0.334078895475038 0.354738119875491 no 1179 0.36916001251967 1801 3414906
SGTC_1653 st012112 65 µM 0.333634648442165 0.354926754920147 no 1180 0.369327634625457 1800 720429
SGTC_3324 9138759 60.749 µM 0.333337306232012 0.355053031486397 no 1181 0.36943984087743 1751 45595710
SGTC_216 k038-0035 28.382 µM 0.332868047194488 0.355252350816256 no 1182 0.3696169449777 1814 4444231 YPR107C YTH1
SGTC_1501 4491-0275 38.4 µM 0.33228702889996 0.355499195135033 no 1183 0.369836266718823 1826 5104718
SGTC_104 0074-0074 590.992 µM 0.331951322852934 0.355641846736147 no 1184 0.369963007740635 1821 3943124
SGTC_3155 9099265 49.47 µM 0.33146778081021 0.355847353835287 no 1185 0.370145586951466 1769 25236499
SGTC_2513 baicalein 25.65 µM 0.331442505434632 0.355858097113151 no 1186 0.370155131411026 1643 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_863 0466-0191 129 µM 0.330931623555982 0.356075271570904 no 1187 0.370348067198761 1821 765160 YPR165W RHO1
SGTC_3217 9129673 49.47 µM 0.330678256231989 0.356182994640459 no 1188 0.37044376409058 1733 17248312
SGTC_2322 7413319 38.22 µM 0.329418128931969 0.356718927786379 no 1189 0.370919833437168 1746 1840400
SGTC_1122 capsaicin 818.572 nM 0.329261253827571 0.356785666721231 no 1190 0.370979113860672 1802 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3343 9148379 18.9835 µM 0.327710516818702 0.357445627980697 no 1191 0.37156527543488 1858 1955036
SGTC_3071 9117417 49.47 µM 0.326097466854935 0.358132560970175 no 1192 0.372175306762956 1866 45595590 YGL055W OLE1
SGTC_3238 9133470 49.47 µM 0.324671417771238 0.358740240619402 no 1193 0.372714884515694 1842 3534688
SGTC_922 1866-0035 480 µM 0.323782223585276 0.359119332477154 no 1194 0.373051457684189 1757 3156169
SGTC_663 1486-0733 13.9 µM 0.323708904494418 0.359150596942861 no 1195 0.373079214374258 1761 722445 YPR165W RHO1
SGTC_812 4251-0442 148 µM 0.323262591554085 0.359340932458742 no 1196 0.373248190985561 1850 5723007
SGTC_4 0960-0234 25.671 µM 0.321500970981538 0.360092537141101 no 1197 0.373915388275179 1739 6821112
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.321176179858797 0.360231170153108 no 1198 0.374038441194261 1851 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_311 1315-0136 58 µM 0.319340749751597 0.361014945402599 no 1199 0.374734067585877 1830 6759207
SGTC_2508 celastrol 40.54 µM 0.317277499025039 0.361896702933408 no 1200 0.375516524609229 1752 122724 Celastrol is a natural product and antioxidant.
SGTC_25 0118-0223 35.662 µM 0.316588736922797 0.362191218101263 no 1201 0.375777841570104 1817 5333628
SGTC_3194 9111903 49.47 µM 0.316249777286687 0.362336187456169 no 1202 0.375906464091263 1809 17087251
SGTC_1656 st012921 11 µM 0.315692232090355 0.362574686422215 no 1203 0.376118061655116 1835 6732821
SGTC_1974 st069448 26.9 µM 0.315401671921862 0.362698999375389 no 1204 0.376228348780902 1872 6323587 YNR016C ACC1
SGTC_1211 1056-0033 32.3 µM 0.315378043984253 0.362709108963579 no 1205 0.376237317616837 1885 6741922
SGTC_2237 6667747 47.222 µM 0.314911103827837 0.362908916347986 no 1206 0.376414575300207 1712 729940 YDL015C TSC13
SGTC_2671 danthron 100 µM 0.31466906495492 0.363012501387418 no 1207 0.376506467248444 1757 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_937 3122-0005 46.7 µM 0.314487577987223 0.363090178687753 no 1208 0.376575374784805 1884 759535
SGTC_3040 9091894 49.47 µM 0.313621981932532 0.363460735427346 no 1209 0.376904081064932 1841 25236966
SGTC_1991 st073000 8.92 µM 0.313170860807263 0.363653908490504 no 1210 0.377075427711002 1835 4301969 YIL048W NEO1
SGTC_678 1218-2179 85.9 µM 0.31273788713539 0.363839343298252 no 1211 0.377239904286491 1794 6820081 YOR116C RPO31
SGTC_1120 ficusin 1.78878 µM 0.31197524623054 0.364166046174342 no 1212 0.377529667886223 1848 6199 A DNA cross-linker.
SGTC_573 3702-0553 84.7 µM 0.311862484451185 0.364214359858377 no 1213 0.3775725173111 1766 1222756
SGTC_3311 9131146 2.8755 µM 0.311448445537681 0.364391776637043 no 1214 0.37772986483062 1761 4900406 YPR165W RHO1
SGTC_3149 9097855 49.47 µM 0.309264118775477 0.365328246689031 no 1215 0.378560311505277 1898 25236625 YMR079W SEC14
SGTC_235 0330-0087 5 mM 0.308632162889131 0.365599330514763 no 1216 0.378800676016166 1760 46494818 YHR062C RPP1
SGTC_382 3229-0966 23.2 µM 0.308426342548479 0.365687633718216 no 1217 0.378878969937801 1853 5722370
SGTC_951 1171-0579 82.7 µM 0.306890021993526 0.366346986652391 no 1218 0.379463542072388 1712 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_492 tmb-8 126 µM 0.305657084341038 0.366876420353976 no 1219 0.379932876040658 1880 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2629 bisabolol 100 µM 0.304866441813312 0.367216062219147 no 1220 0.380233937675981 1816 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_476 mead acid 10 µM 0.30348959455545 0.367807772114011 no 1221 0.38075838806201 1777 5312531 An omega 9 fatty acid.
SGTC_384 k007-0144 5.16 µM 0.302595887838777 0.368192017008021 no 1222 0.381098924335168 1790 6824886
SGTC_3132 9126706 49.47 µM 0.302566653127625 0.368204588560934 no 1223 0.381110065429849 1805 850858
SGTC_2309 7664088 163.95 µM 0.301998402216805 0.368448976658624 no 1224 0.3813266404838 1933 704922
SGTC_1139 k015-0024 46.9 µM 0.299620101940113 0.369472390588809 no 1225 0.382233474555462 1910 2766652
SGTC_1243 0416-0003 5.65 µM 0.299214565355027 0.369646990888062 no 1226 0.382388168278603 1761 2141977
SGTC_1321 1326-2144 215 µM 0.299196644377348 0.369654707231794 no 1227 0.382395004748037 1894 3513030
SGTC_2348 9022543 33.42 µM 0.298783995837705 0.369832398323296 no 1228 0.382552431469845 1807 3162678 YDL140C RPO21
SGTC_116 0155-0182 31.788 µM 0.298773406934509 0.369836958389775 no 1229 0.382556471425418 1755 771486
SGTC_2811 7967822 32.47 µM 0.298127998922569 0.370114935160491 no 1230 0.382802736312505 1848 2232244
SGTC_658 3253-0951 102 µM 0.297921322058275 0.370203965090251 no 1231 0.382881606921395 1804 1184878
SGTC_1199 1638-0010 4.46 µM 0.296890515523489 0.370648108063777 no 1232 0.383275048702105 1748 3111136
SGTC_571 k831-0106 44.2 µM 0.291053808120199 0.373166203235167 no 1233 0.385505083502873 1919 4783639
SGTC_1815 st051655 58.2 µM 0.290482528027897 0.373412960452599 no 1234 0.385723557720267 1917 5984156
SGTC_2330 7979373 200 µM 0.29041249479523 0.373443213996899 no 1235 0.385750342973135 1676 1863007
SGTC_1360 1598-0022 39.8 µM 0.290083990416052 0.373585134487398 no 1236 0.38587599163449 1872 761525
SGTC_80 0159-0065 512.242 µM 0.288422580135913 0.374303159368727 no 1237 0.386511642663933 1907 1548079
SGTC_2730 imipramine 71.33 µM 0.288085492083151 0.374448894700717 no 1238 0.386640648861734 1894 3696 A tricyclic antidepressant.
SGTC_598 3937-0236 20.2 µM 0.287857685433914 0.374547393896935 no 1239 0.38672783931869 1864 1379313
SGTC_65 0798-0905 34.986 µM 0.28668236903275 0.375055707963487 no 1240 0.387177769333323 1958 3602145
SGTC_5 0352-0601 109.883 µM 0.286386089929666 0.375183880379451 no 1241 0.387291213688845 1825 762456
SGTC_2409 alverine citrate 63.97 µM 0.28593162797833 0.375380510584865 no 1242 0.387465244473574 1894 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1427 4048-4900 550 nM 0.285644421542256 0.375504791727839 no 1243 0.387575238417906 1924 24132586
SGTC_2845 9003024 42.97 µM 0.285630204263392 0.375510944222595 no 1244 0.387580683567207 1881 2990173
SGTC_2598 perillyl alcohol 100 µM 0.284100196137029 0.376173236456988 no 1245 0.388166798330236 1860 10819 An apoptosis inducer.
SGTC_442 cape 100 µM 0.284096224625601 0.376174956074497 no 1246 0.388168320067022 1922 5281787
SGTC_851 0394-0702 453 µM 0.280085183831279 0.377912938843518 no 1247 0.389706075780269 1923 762646
SGTC_1381 2324-0066 62.1 µM 0.279703931373504 0.378078264721999 no 1248 0.389852330938295 1829 10885928
SGTC_2115 tiliquinol 12.7705 µM 0.279144332038169 0.378320969168652 no 1249 0.390067031342411 1847 71208 A bioactive hydroxyquinoline.
SGTC_314 1671-0008 2.74 µM 0.278961305664148 0.378400360164805 no 1250 0.390137260002455 1847 3913060
SGTC_2375 9072683 200 µM 0.277511398589169 0.379029464704561 no 1251 0.390693727297124 1970 16798029
SGTC_3104 9120930 49.47 µM 0.276046857187126 0.379665244434656 no 1252 0.391256038522123 1828 17014836
SGTC_1078 idebenone 36.1 µM 0.275973078622587 0.379697281458332 no 1253 0.391284371854991 1839 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_3128 9127691 49.47 µM 0.274515038007765 0.380330578708866 no 1254 0.391844424342942 1837 41316314
SGTC_2782 7736369 71.43 µM 0.274487125802948 0.380342705459369 no 1255 0.391855147976897 1777 2950836 YOL077C BRX1
SGTC_1808 st050063 61.5 µM 0.271629510913566 0.381584846619896 no 1256 0.392953452943013 1911 4011993
SGTC_1050 3232-1156 69.3 µM 0.267200772901239 0.383512327330286 no 1257 0.394657290545125 1797 700529
SGTC_2701 st077767 14.721 µM 0.266182741126823 0.38395580609017 no 1258 0.395049237138558 1819 5721188
SGTC_2819 7996655 46.38 µM 0.265516745069598 0.384246012036961 no 1259 0.395305705973777 1917 6456960
SGTC_1558 st069300 45.6 µM 0.265474772726516 0.384264303545499 no 1260 0.395321870649832 1957 24208000
SGTC_245 methotrexate 289.6 µM 0.265401907851376 0.384296058603214 no 1261 0.395349933297027 1885 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1392 3455-1037 33.9 µM 0.265383868462042 0.384303920423984 no 1262 0.395356880939834 1918 981132
SGTC_1666 st014829 29 µM 0.264523753929733 0.384678825671929 no 1263 0.39568818174333 1824 3858230
SGTC_1506 4226-2149 212 µM 0.262461458385882 0.385578174295148 no 1264 0.396482847908294 1855 991114
SGTC_421 streptovitacin 30 mM 0.262288054140743 0.385653822454576 no 1265 0.396549685572367 1798 91467 include heat shock
SGTC_2948 9070189 9.45 µM 0.262194852583463 0.385694483730938 no 1266 0.396585610830134 1969 6473636 YDL196W YDL196W
SGTC_857 0438-0306 1.35 µM 0.262077216470629 0.385745806925139 no 1267 0.396630955828743 1868 4686136
SGTC_1450 4112-4260 37.6 µM 0.261460656862816 0.386014837021348 no 1268 0.396868642897015 1944 1633175
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.260681229456196 0.386355011426353 no 1269 0.397169171213436 1883 4000243
SGTC_1502 4534-4282 27.7 µM 0.260637167096438 0.386374244676793 no 1270 0.39718616241671 1853 3278949
SGTC_2812 7970281 58.44 µM 0.259397148813808 0.386915627828987 no 1271 0.397664414683654 1933 2233435
SGTC_2617 dihydrotanshinone i 20.83 µM 0.25921573341898 0.38699485097919 no 1272 0.397734396185735 1807 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_374 0880-0231 82.3 µM 0.257657697573078 0.387675430574763 no 1273 0.398335548200091 1913 6833587
SGTC_1475 4092-1048 11.7 µM 0.256917379508925 0.387998936674542 no 1274 0.398621276945176 1860 2881759
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.255706762383771 0.388528122694752 no 1275 0.399088636553345 1984 6708630 An antioxidant.
SGTC_2852 9023854 51.95 µM 0.254557814671125 0.389030543168899 no 1276 0.399532322481463 1904 19798528
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.254250074291088 0.389165145742292 no 1277 0.39965118378361 1835 688803
SGTC_617 3770-0098 35 µM 0.253405465508782 0.389534637508615 no 1278 0.399977452299669 1858 5962639
SGTC_852 0418-0143 439 µM 0.253380864689602 0.389545401149718 no 1279 0.399986956531555 1960 5369229
SGTC_1846 st056244 14.8 µM 0.251970944764884 0.390162427312672 no 1280 0.400531761036407 1899 5393182
SGTC_3205 9113483 49.47 µM 0.251625348189692 0.390313713756217 no 1281 0.400665331938141 1964 17018033
SGTC_1185 1319-0113 81.3 µM 0.250164815325135 0.390953251722008 no 1282 0.401229946798892 1903 4672763
SGTC_662 k832-1615 104 µM 0.249259341374508 0.391349888815744 no 1283 0.401580089883005 1900 5878478
SGTC_2960 9079389 5.97 µM 0.248597415272015 0.391639912851763 no 1284 0.401836104029566 1982 16457355
SGTC_81 0411-0046 9.971 µM 0.248280102247365 0.391778965457516 no 1285 0.401958846607574 1897 12925265
SGTC_1482 3346-2049 8.48 µM 0.247524814851293 0.39211000235929 no 1286 0.402251044697924 1949 3826804
SGTC_2194 5927483 104.545 µM 0.245428942851741 0.393029016012689 no 1287 0.403062160508499 1908 760979
SGTC_2744 captopril 92.04 µM 0.245383549155271 0.393048927198904 no 1288 0.403079732787526 1982 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_3173 9105693 49.47 µM 0.243155034483865 0.394026770991677 no 1289 0.403942649437459 1923 17096658
SGTC_1041 0206-0046 107 µM 0.242999177824973 0.394095183984387 no 1290 0.404003017183578 1851 50494
SGTC_611 3453-1652 23.7 µM 0.242884404367257 0.394145565671205 no 1291 0.404047473691534 1981 1560575
SGTC_22 0964-0034 14.468 µM 0.241586912667349 0.394715243886552 no 1292 0.404550131964627 1870 138402
SGTC_3038 9091290 49.47 µM 0.239771173039779 0.395512842497291 no 1293 0.4052538278688 1963 25236843
SGTC_219 mitoxanthrone 164.414 µM 0.239026054872803 0.395840276902737 no 1294 0.405542689681208 1954 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1456 k015-0012 13 µM 0.238696750251712 0.395985009822006 no 1295 0.405670368425656 2039 2989616
SGTC_2009 4012297 12.05 µM 0.238293740483484 0.396162156458029 no 1296 0.405826637955189 1856 45595307
SGTC_2792 7535235 81.82 µM 0.238283414990192 0.396166695405101 no 1297 0.405830641926345 1807 1281891
SGTC_54 0159-0055 9 µM 0.238242577591213 0.39618464711078 no 1298 0.405846477757106 2012 3319099
SGTC_2928 9011484 9.79 µM 0.236729939960518 0.396849742030064 no 1299 0.40643315316352 1869 2994751
SGTC_1048 3161-0300 24.5 µM 0.236036987101123 0.397154528344703 no 1300 0.406701984679817 1901 2165101
SGTC_1971 st069429 63.5 µM 0.235192622035374 0.397525996244491 no 1301 0.407029616085755 2010 1246522 YGL099W LSG1
SGTC_406 estrone 100 µM 0.234921387460023 0.397645342260144 no 1302 0.40713487462522 2015 5870 A steroid.
SGTC_52 0329-0193 875 nM 0.23474160142914 0.397724455252054 no 1303 0.407204648243493 1971 3739292
SGTC_2297 7971671 152.32 µM 0.232924510163068 0.398524283125181 no 1304 0.407910012738834 1965 909016
SGTC_2033 5192550 145 µM 0.232479380068819 0.398720280903404 no 1305 0.408082850429078 1852 182073
SGTC_2231 micatex 6.853 µM 0.232006331983334 0.398928599409904 no 1306 0.408266547882579 1939 20737 An antifungal of unknown mechanism.
SGTC_913 3487-1245 167 µM 0.231904171083794 0.398973592289093 no 1307 0.408306222390513 1832 4016153
SGTC_3000 9075062 71.4286 µM 0.231129039050101 0.399315013376256 no 1308 0.408607277957244 1879 17057871
SGTC_3081 9117243 49.47 µM 0.230926402150815 0.39940428121691 no 1309 0.408685989535644 2002 45595589
SGTC_294 k038-0071 157 µM 0.230764873195881 0.399475443500429 no 1310 0.408748735924338 1885 24152826
SGTC_128 0906-2981 13.371 µM 0.230292315457083 0.399683650037085 no 1311 0.408932315766418 2010 6740226
SGTC_2465 5809242 33.21 µM 0.229744278408956 0.399925148097684 no 1312 0.409145242926806 1942 2731748
SGTC_2096 5468907 200 µM 0.229725489154826 0.399933428451536 no 1313 0.409152543534029 2018 759785
SGTC_783 0848-0141 92.7 µM 0.229497612344415 0.400033856488441 no 1314 0.409241088092455 1872 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2074 5212007 75.395 µM 0.229176006008241 0.40017560349782 no 1315 0.409366060380344 2048 758611
SGTC_401 neomycin 50 µM 0.229143577797274 0.400189896862867 no 1316 0.409378662097848 1928 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2837 9008476 45.46 µM 0.22737080208573 0.400971485191746 no 1317 0.41006771115303 1932 2992805
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.226944223282048 0.401159616238951 no 1318 0.410233556931305 1893 115019
SGTC_1534 6-azauridine 81.6 µM 0.225169286119706 0.401942649898243 no 1319 0.410923791030225 1913 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_779 1360-0071 233 µM 0.224557893572781 0.402212463993002 no 1320 0.411161612164435 2053 7566
SGTC_822 1487-0950 154 µM 0.224505027038273 0.402235796753035 no 1321 0.411182177867716 2021 1958375
SGTC_569 4130-2812 160 µM 0.224472379111068 0.402250206160739 no 1322 0.411194878417038 2045 743552
SGTC_2679 rapamycin 1 nM 0.224198221727243 0.402371212819148 no 1323 0.411301533556669 1925 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1920 st075728 45.7 µM 0.221942514630939 0.403367183338051 no 1324 0.412179316935238 2044 3400306
SGTC_2134 5324836 1.464 µM 0.221463415019599 0.403578802882583 no 1325 0.412365809969401 1926 699272
SGTC_2311 7694451 200 µM 0.221036642556935 0.403767333167171 no 1326 0.412531950943387 1949 2163142
SGTC_142 0335-0849 62.6745 µM 0.220822697532865 0.403861853577913 no 1327 0.412615244866158 1932 3889043 YPR107C YTH1
SGTC_2226 7298446 200 µM 0.22026838638424 0.404106773048664 no 1328 0.412831069771553 2015 3283010
SGTC_2414 st077232 92.9 µM 0.219735339447818 0.404342332498792 no 1329 0.413038640164821 1776 729801
SGTC_1152 3909-8331 15.9 µM 0.218968185186139 0.404681407470993 no 1330 0.413337415454175 1901 16001939
SGTC_270 tamoxifen 5.46 µM 0.218888177656926 0.404716774173673 no 1331 0.413368578016151 2042 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_616 4092-0450 108 µM 0.216821711079609 0.405630508468599 no 1332 0.414173645712856 1955 787165
SGTC_1941 st076221 61.8 µM 0.216361273229017 0.405834171595777 no 1333 0.414353075398368 2057 2828568
SGTC_2870 9038528 12.99 µM 0.215412208300501 0.406254047008295 no 1334 0.414722976287554 1927 6463316
SGTC_2175 5807670 165.306 µM 0.215028428585536 0.406423865474925 no 1335 0.414872577070219 2035 241186
SGTC_3178 9107506 49.47 µM 0.214292473597944 0.406749566993428 no 1336 0.415159493460235 1978 8897194
SGTC_837 0091-0265 12.5 µM 0.214008925443871 0.406875070244319 no 1337 0.4152700484638 1898 759367
SGTC_2016 5121758 140 µM 0.211874338507983 0.407820180987207 no 1338 0.416102535500773 2003 2795203
SGTC_75 0159-0059 199.013 µM 0.211500843672927 0.407985605063022 no 1339 0.416248236973212 2017 5377270
SGTC_1876 myriocin 605 nM 0.210534333319825 0.40841375689185 no 1340 0.416625328988037 2053 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_3285 9112818 20.8695 µM 0.210076229357367 0.408616729366813 no 1341 0.416804088868145 1968 17017947 YPR165W RHO1
SGTC_392 N-ethylmaleimide 8.33 µM 0.210028676833229 0.408637799905564 no 1342 0.416822645650014 1903 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_989 1501-0895 10.3 µM 0.20854737644069 0.409294296535238 no 1343 0.417400797334939 2048 2830112
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.208457679871409 0.409334057293146 no 1344 0.417435811662482 2018 165506
SGTC_2974 9094440 9.66 µM 0.206898016219733 0.410025574853924 no 1345 0.418044752913206 1989 25236134
SGTC_1043 0916-0009 19.3 µM 0.206588722417778 0.410162741654817 no 1346 0.418165534239893 2102 3101130
SGTC_2058 5236698 133 µM 0.206400746684714 0.410246111224992 no 1347 0.418238943809463 1930 766665
SGTC_831 k061-1017 217 µM 0.204704152093551 0.410998755074629 no 1348 0.41890163810194 2019 1240153
SGTC_526 4469-0568 170 µM 0.204486814699267 0.411095194101396 no 1349 0.418986547328874 1862 2901964
SGTC_3327 9140648 26.9345 µM 0.201468895147148 0.412434887066423 no 1350 0.420165974417083 2042 8029710
SGTC_1151 3909-8316 15.3 µM 0.20095432389374 0.412663414105595 no 1351 0.420367144842526 1945 800431
SGTC_2397 5161689 200 µM 0.200698480870169 0.412777047972977 no 1352 0.420467173819071 1998 2259942
SGTC_85 0868-0259 160.055 µM 0.199539234851354 0.413292023940283 no 1353 0.420920477701806 1970 83173
SGTC_2950 9072895 21.46 µM 0.199199898445009 0.41344279682576 no 1354 0.421053189429451 1890 17332245
SGTC_1937 st074714 47.2 µM 0.196695381283513 0.414555989372498 no 1355 0.422032962345653 1822 17250970
SGTC_2722 naftopidil 47.16 µM 0.196650279939029 0.414576042063748 no 1356 0.422050610539081 2038 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_666 0272-0154 136 µM 0.195469537675845 0.41510109571426 no 1357 0.422512691549674 1975 6870312
SGTC_3310 9130229 44.1445 µM 0.194961232753817 0.415327176011489 no 1358 0.422711648493941 2041 7761258
SGTC_691 1548-0686 185 µM 0.193118297995783 0.416147098177525 no 1359 0.423433161332635 1917 46495133
SGTC_3027 9089541 49.47 µM 0.192976918424681 0.416210013108947 no 1360 0.423488522369662 1959 9943819
SGTC_1140 3229-1848 2.98 µM 0.191146839155209 0.41702460483187 no 1361 0.42420527588643 2072 2849525
SGTC_1090 efavirenz 20.7 µM 0.190815845344449 0.417171972571072 no 1362 0.424334936996675 2003 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2360 9040895 200 µM 0.188388245886405 0.418253162390542 no 1363 0.425286156579761 1938 4914414
SGTC_37 0566-0070 1.56 µM 0.186621728738013 0.419040312259862 no 1364 0.425978614489126 2054 1626686
SGTC_3127 9126946 49.47 µM 0.185128046005848 0.419706141772987 no 1365 0.426564302136186 1906 27243249
SGTC_2567 aureobasidin a 60 nM 0.184953267582469 0.4197840667092 no 1366 0.426632845079791 1983 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2556 citropten 84.59 µM 0.183963414616966 0.420225451781894 no 1367 0.427021077973071 1977 2775 A potential DNA crosslinker.
SGTC_1539 benzyladenosine 56 µM 0.18220494946056 0.421009815643961 no 1368 0.427710944452471 1982 92208 A nucleotide analog.
SGTC_2130 NSC 7 2.4545 µM 0.181787866858996 0.421195901585365 no 1369 0.427874603355275 2058 21448
SGTC_720 r052-1644 49.9 µM 0.180870234049989 0.421605375367269 no 1370 0.428234716632535 1989 1422863 YOR257W CDC31
SGTC_1169 aniline yellow 25.8 µM 0.180356458011231 0.421834673858383 no 1371 0.428436367598984 2020 6051 A DNA damaging agent.
SGTC_221 trifluoperazine 10.304 µM 0.178980438411014 0.422448922398609 no 1372 0.428976530778146 2069 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_509 pifithrin 175 µM 0.177505714611748 0.423107441417268 no 1373 0.429555588449896 2100 4817 A p53 inhibitor.
SGTC_1275 0867-0008 21.1 µM 0.176600635864352 0.423511699265605 no 1374 0.429911047294149 2014 3422836
SGTC_1422 4031-0024 15.5 µM 0.176465415909985 0.423572102843768 no 1375 0.429964158198153 2083 782427
SGTC_2317 5986382 200 µM 0.17586136263038 0.423841959040255 no 1376 0.43020143018039 2045 877883
SGTC_2495 cafestol 54.53 µM 0.174773853885426 0.424327885235805 no 1377 0.430628666837333 2032 16667697 An anti-infammatory.
SGTC_2022 5136654 200 µM 0.174637717433327 0.424388722536134 no 1378 0.43068215487946 2014 1713771
SGTC_2220 6782180 200 µM 0.17437514255498 0.424506068324283 no 1379 0.430785324198133 2090 833803
SGTC_1597 7-benzyloxygramine 47.5 µM 0.173987717074231 0.424679222575801 no 1380 0.430937557678602 1952 260807
SGTC_2955 9076254 12.21 µM 0.172572015096893 0.425312073589112 no 1381 0.431493925271399 2097 16459619
SGTC_343 4130-2827 29.8 µM 0.172368353137079 0.425403130997331 no 1382 0.43157397515958 1947 1118244
SGTC_1339 1486-1321 22.7 µM 0.171199127431845 0.425925969499648 no 1383 0.432033596787551 1977 3469382
SGTC_1562 morin hydrate 59.1 µM 0.170463046709861 0.42625518696695 no 1384 0.432322996726733 1999 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_814 3342-0569 96 µM 0.169027271395793 0.426897495640555 no 1385 0.432887595275084 2074 4346283
SGTC_260 nsc-65238 3.989 µM 0.168339861497017 0.427205084181919 no 1386 0.433157958177486 2069 3246252
SGTC_1003 4049-0218 100 µM 0.167996402055844 0.427358785191161 no 1387 0.433293054798175 2051 295161
SGTC_465 cgp-37157 41 µM 0.167955136604424 0.427377252572668 no 1388 0.433309286709828 2126 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_3212 9128307 49.47 µM 0.167849130756877 0.427424693724025 no 1389 0.433350985001514 1792 27243542
SGTC_33 0986-0033 35.816 µM 0.166950590881305 0.427826862360725 no 1390 0.433704462971182 2107 2848082
SGTC_3065 9113888 49.47 µM 0.166880755600251 0.427858122394267 no 1391 0.433731937803217 2065 16648368
SGTC_150 3970-0969 77.2 µM 0.165560560230598 0.428449160123708 no 1392 0.434251393618517 2005 6615640
SGTC_769 0302-0231 76 µM 0.165112707744802 0.428649695551188 no 1393 0.434427635479677 2101 571869 YER009W NTF2
SGTC_2920 7982904 15.77 µM 0.165104904790472 0.42865318965254 no 1394 0.434430706265294 2002 6456808
SGTC_560 2332-1943 155 µM 0.162409656245931 0.429860433403185 no 1395 0.435491633603675 2073 21177716
SGTC_959 1222-0044 107 µM 0.162086026351154 0.430005436609525 no 1396 0.435619055021568 2158 6083612
SGTC_2921 7974240 10.71 µM 0.161827326184191 0.430121354675273 no 1397 0.435720916742478 2060 2979074 YDR527W RBA50
SGTC_1055 3448-0672 86 µM 0.161089293244428 0.430452084673152 no 1398 0.436011536433648 2039 748378
SGTC_868 0527-0199 213 µM 0.159907047586889 0.430981978473838 no 1399 0.436477148395418 2011 2849450
SGTC_165 k038-0023 64.381 µM 0.158640654445446 0.431549725810017 no 1400 0.436975998378089 2037 46368543
SGTC_2294 7971431 200 µM 0.1583255048247 0.431691035204823 no 1401 0.437100155829807 2083 5741572
SGTC_586 0957-0265 8.15 µM 0.157863542431892 0.431898189518969 no 1402 0.437282163349978 2137 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_3337 9144342 33.5465 µM 0.155868543985719 0.432793005996661 no 1403 0.438068320239695 2086 17682949
SGTC_1956 st077085 54 µM 0.155828252027246 0.432811081712223 no 1404 0.438084200375577 1988 24208685
SGTC_1968 st069590 43.6 µM 0.155020519395009 0.433173475075885 no 1405 0.438402570358089 2117 6384066
SGTC_3221 9128209 49.47 µM 0.154515650793079 0.433400015510181 no 1406 0.438601585931014 2036 16460723
SGTC_2546 rhodinyl acetate 100 µM 0.15386765477725 0.433690810945018 no 1407 0.438857044046525 2152 6708682
SGTC_1803 st050068 52.4 µM 0.153491516744253 0.43385962355551 no 1408 0.439005339848125 2135 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_3291 9121177 71.43 µM 0.153031351242717 0.434066164515127 no 1409 0.439186775877315 2010 17015612
SGTC_236 1509-0011 5.31 µM 0.15296998612526 0.434093709032825 no 1410 0.439210972145607 2101 3107280
SGTC_1249 0481-0015 10.2 µM 0.152859903301588 0.434143121917787 no 1411 0.439254378376558 2031 4227577
SGTC_1441 4106-0040 13 µM 0.15279619858045 0.434171717530641 no 1412 0.439279497813712 2129 2904180
SGTC_2277 7947813 106.88 µM 0.151145694676828 0.434912711166699 no 1413 0.439930393691853 2131 1246798
SGTC_3110 9122132 49.47 µM 0.151025582617831 0.434966644425825 no 1414 0.439977767673288 2113 918317
SGTC_1007 4101-0031 70 µM 0.150730819856313 0.435099005258486 no 1415 0.440094030128695 2147 1146276
SGTC_1716 st033144 30.6155 µM 0.150219262402844 0.435328733248137 no 1416 0.440295814566842 2145 674617
SGTC_2483 5729050 27.16 µM 0.150214041764978 0.435331077822068 no 1417 0.4402978739336 2135 2865180
SGTC_2824 7998404 51.95 µM 0.149862551640622 0.43548893628338 no 1418 0.440436528725372 2058 837851
SGTC_1171 0368-0077 21.4 µM 0.14978595941931 0.435523336140329 no 1419 0.440466743569617 2022 3239779
SGTC_2849 9019321 12.99 µM 0.149127145108206 0.435819249468796 no 1420 0.440726653341525 2055 16489627
SGTC_651 3253-0966 34.4 µM 0.148307218881404 0.436187578070106 no 1421 0.441050159259768 2062 781462
SGTC_1914 st062367 72.6 µM 0.147373398861068 0.436607137622451 no 1422 0.44141865043913 2032 978205
SGTC_661 1304-0007 33.6 µM 0.146610170033669 0.436950104600885 no 1423 0.441719862953028 2019 3117130
SGTC_1510 1123-0200 71.5 µM 0.146450563721083 0.437021831810758 no 1424 0.441782856741656 2120 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2059 5238311 157 µM 0.146342436745003 0.43707042534038 no 1425 0.441825533383436 2035 703021
SGTC_1806 st050005 60.3 µM 0.146337697021206 0.437072555449501 no 1426 0.44182740412072 1995 5194765
SGTC_3227 9130768 49.47 µM 0.145597425302588 0.437405267978506 no 1427 0.442119600318288 2094 17720899
SGTC_2256 7954252 200 µM 0.145101145865697 0.437628343832991 no 1428 0.442315506797455 2017 2972920
SGTC_2877 9040724 71.43 µM 0.144718602011178 0.437800309479865 no 1429 0.44246652574722 2180 6463895
SGTC_2167 5876490 200 µM 0.144532103052848 0.437884150963659 no 1430 0.442540154003786 2128 686534
SGTC_2250 alverine citrate 130 µM 0.143575671896317 0.438314162828601 no 1431 0.442917776300172 1999 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_3146 9095609 49.47 µM 0.143175655460874 0.438494032024316 no 1432 0.443075727923499 2072 17173999
SGTC_3044 9093193 49.47 µM 0.142473060330576 0.438809987828713 no 1433 0.443353178511722 2009 25236277
SGTC_657 3534-0529 86.7 µM 0.140738338105324 0.439590255977106 no 1434 0.444038328541423 2150 1049549
SGTC_53 0973-0023 39.979 µM 0.139804657205593 0.440010317677599 no 1435 0.444407166759831 2206 674768
SGTC_893 0958-0369 48.9 µM 0.139628238128847 0.440089695968128 no 1436 0.444476864187073 2178 6819948
SGTC_1769 st044406 64.4 µM 0.139214385522382 0.440275914937735 no 1437 0.444640370597341 2003 670903
SGTC_2064 5220758 200 µM 0.138880528457818 0.440426148385009 no 1438 0.444772278941051 2071 788518
SGTC_127 0180-0333 59.125 µM 0.137945881203866 0.440846778945923 no 1439 0.445141594522591 2168 771601
SGTC_3092 9117248 49.47 µM 0.13753250358801 0.441032837570135 no 1440 0.445304951347257 2143 17141857
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.137288798735575 0.441142533668884 no 1441 0.445401261957595 2067 23665772 A membrane-active detergent.
SGTC_2569 tetrandrine 100 µM 0.136726143699053 0.441395812427594 no 1442 0.445623631954407 1958 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1084 voriconazole 435 nM 0.136581806422715 0.441460789615399 no 1443 0.445680679044526 2177 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.135694312327649 0.441860352781848 no 1444 0.446031472118526 2107 5106787 A p450 inhibitor.
SGTC_1810 st050138 53 µM 0.135402240880088 0.441991860692141 no 1445 0.446146926241969 2183 3444541
SGTC_1021 4476-0760 85.3 µM 0.134308745687765 0.442484273828262 no 1446 0.44657921892219 1967 746768
SGTC_1659 st012954 42.1 µM 0.132815726002637 0.443156740680905 no 1447 0.447169558497409 2120 24207262
SGTC_2718 lomofungin 53.02 µM 0.132686655291439 0.443214882779713 no 1448 0.44722059853777 2144 5351222 A RNA synthesis inhibitor.
SGTC_100 0086-0128 49.5915 µM 0.13186244455018 0.443586191317498 no 1449 0.447546547043782 1967 93297
SGTC_1901 st060216 58.6 µM 0.13051596672962 0.444192888605282 no 1450 0.448079111283838 2176 688792
SGTC_23 0213-0011 39.996 µM 0.129542522345936 0.444631585668248 no 1451 0.448464190210916 2177 627608
SGTC_1995 st072814 61.1 µM 0.128890398101891 0.444925513048863 no 1452 0.448722187249036 2017 5769371
SGTC_2493 resveratrol 26.09 µM 0.126801041667742 0.445867437156511 no 1453 0.449548935631305 2120 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2436 5633522 8.09 µM 0.126581403094343 0.445966472507548 no 1454 0.449635858354007 2195 5724242
SGTC_1394 3474-0001 65.7 µM 0.12606842524234 0.446197788085155 no 1455 0.449838880513833 2086 5017666 YIL048W NEO1
SGTC_813 k007-0158 173 µM 0.125842157748277 0.446299824037862 no 1456 0.449928434979792 2158 6523916
SGTC_1936 st074407 74.3 µM 0.125725503873707 0.446352430815118 no 1457 0.449974606441415 2069 809813
SGTC_1407 3909-7909 12.3 µM 0.125600919124594 0.446408615179382 no 1458 0.450023917681314 2107 4411780
SGTC_2384 9036245 200 µM 0.124879507181721 0.446733973640896 no 1459 0.450309471127441 2143 6462766
SGTC_350 k064-0020 19.8 µM 0.12447136472129 0.446918062734595 no 1460 0.450471035839937 2198 2790705
SGTC_2783 7738165 71.43 µM 0.124263108514105 0.447011999288517 no 1461 0.450553477999171 2033 17201110
SGTC_2597 laccaic acid a 100 µM 0.123818775995006 0.447212430932224 no 1462 0.450729382560018 2102 5491415 A textile dye.
SGTC_191 3914-0123 66.505 µM 0.123378382746364 0.447411098934814 no 1463 0.450903737172679 2064 3144412
SGTC_963 1269-2853 151 µM 0.123013688676254 0.447575627892222 no 1464 0.451048129150227 2062 3668223
SGTC_1762 st045503 25.4615 µM 0.121467110412432 0.448273454826671 no 1465 0.451660531933656 2079 4645554
SGTC_2492 derrusnin 100 µM 0.121128037109491 0.448426468545341 no 1466 0.451794811135516 2093 1715307 Part of coumarin class of compounds.
SGTC_816 0325-0417 81.3 µM 0.120314284268418 0.448793722312773 no 1467 0.452117094549197 2079 68101
SGTC_1207 2099-0101 141 µM 0.120253679781483 0.448821075406851 no 1468 0.452141097968248 2182 5837381
SGTC_151 3013-0144 2.285 µM 0.119883954086789 0.448987951842136 no 1469 0.452287537789229 2197 906558 YHR107C CDC12
SGTC_1219 1469-0211 33.1 µM 0.119786093095301 0.449032123108952 no 1470 0.452326299358284 2195 6822282
SGTC_971 1315-0384 26.7 µM 0.119578179687639 0.449125970551013 no 1471 0.452408652881721 2056 6769120
SGTC_266 formosanin C 406 nM 0.119025995480073 0.449375227902577 no 1472 0.452627380381149 2186 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2651 TUB2.036 5 µM 0.118778185846787 0.449487096300084 no 1473 0.45272554574613 2187 15992207 YFL037W TUB2
SGTC_2213 7173844 200 µM 0.118736011948856 0.449506135210907 no 1474 0.452742252471241 2176 892728
SGTC_815 1582-0027 36.9 µM 0.118571220801426 0.449580529352786 no 1475 0.452807533470925 2127 3128206
SGTC_34 0469-0683 81.75 µM 0.116170835497432 0.450664370919749 no 1476 0.45375857506395 2146 3690923
SGTC_1305 1181-0477 144 µM 0.1160142114359 0.450735103971137 no 1477 0.45382063937672 2191 6252086
SGTC_1804 st050076 49.1 µM 0.116001208044967 0.450740976507784 no 1478 0.453825792189503 2145 3895976
SGTC_2145 5634607 200 µM 0.115045010335235 0.451172839956898 no 1479 0.454204722888397 2099 308662
SGTC_1462 k081-0014 26.5 µM 0.114839869939458 0.45126549846811 no 1480 0.45428602322729 2161 3270634
SGTC_2490 carminic acid 95.39 µM 0.114196284526441 0.45155621252565 no 1481 0.454541098580667 2185 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1022 4477-0945 21.3 µM 0.113962080725255 0.451662011213712 no 1482 0.454633926376233 2106 4648966
SGTC_1011 4112-3381 17.4 µM 0.113456049129413 0.451890616479653 no 1483 0.454834502870245 2137 2877139
SGTC_1798 st045719 60.953 µM 0.112432196631032 0.452353201672982 no 1484 0.455240363971894 2207 3980186
SGTC_892 0929-0076 29 µM 0.111936521004532 0.45257717537819 no 1485 0.455436869492472 2066 5751038
SGTC_2286 7945697 125 µM 0.110602285872755 0.453180131499324 no 1486 0.455965867372909 2104 1245733
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.110146911723951 0.453385945067723 no 1487 0.456146432146225 2209 3256 An antibiotic and ribosome inhibitor.
SGTC_2214 7179297 48.276 µM 0.110100178027124 0.453407067812525 no 1488 0.456164963485859 2189 769744
SGTC_762 1165-0429 115 µM 0.110057536819313 0.453426340944903 no 1489 0.456181872111666 2220 5967793
SGTC_1284 0929-0043 16 µM 0.109446105845522 0.453702709841758 no 1490 0.456424333091341 2101 1239883
SGTC_2534 helenine 20.12 µM 0.109176542941239 0.453824560328251 no 1491 0.456531232550122 2148 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1800 st050079 29.0735 µM 0.108991017309278 0.453908425982809 no 1492 0.456604807519655 2174 3645560
SGTC_50 0929-0078 56.389 µM 0.108541350897124 0.454111703278221 no 1493 0.456783140489256 2147 1377751
SGTC_804 1595-0054 20.9 µM 0.108166767914739 0.454281047354993 no 1494 0.456931702807269 2063 761523 Stimulates phospholipase C.
SGTC_561 1550-0330 72.9 µM 0.108065536810147 0.454326814043778 no 1495 0.456971852829032 2096 6812934
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.107640871494255 0.454518812280077 no 1496 0.457140287281707 2158 15053
SGTC_315 k915-0449 187 µM 0.10657632337387 0.455000158762188 no 1497 0.457562551396326 2129 20970215 YNL149C PGA2
SGTC_2283 7944793 200 µM 0.106196762559391 0.455171797140784 no 1498 0.457713119763135 2145 2970533
SGTC_2 0422-0095 29 µM 0.104386497584766 0.455990518214693 no 1499 0.458431318753818 2145 6790840
SGTC_192 3455-0609 60.9 µM 0.104360675314035 0.456002198106872 no 1500 0.458441564389935 2169 3769639
SGTC_1884 5633444 25 µM 0.104218133935418 0.456066672901196 no 1501 0.458498121767774 2145 5724239
SGTC_601 0986-0029 62.9 µM 0.101512104856727 0.45729089058132 no 1502 0.459571974455291 2155 24747981
SGTC_1308 1187-1617 41.4 µM 0.100701281854933 0.457657789401827 no 1503 0.459893796887732 2183 2882570
SGTC_1206 3978-0017 132 µM 0.100264843757943 0.457855293360948 no 1504 0.460067033711945 2137 3873677
SGTC_2491 paeonol 100 µM 0.100123267938077 0.457919363756843 no 1505 0.460123231502636 2115 11092 Increases levels of cortical cytochrome oxidase.
SGTC_944 3370-0224 231 µM 0.0997735646570501 0.458077627298374 no 1506 0.46026204782608 2142 4580514
SGTC_56 0957-0365 83.25 µM 0.0991432575577365 0.458362899137996 no 1507 0.460512263345078 2227 6752360
SGTC_906 1165-0455 526 µM 0.0980854872845718 0.458841685438496 no 1508 0.460932205711531 2238 3252859
SGTC_479 n-linoleoylglycine 10 µM 0.0978512805351716 0.458947704252198 no 1509 0.461025193374873 2111 6433346 An anti-infammatory.
SGTC_1972 st070201 17.4 µM 0.0969557818871191 0.45935309818565 no 1510 0.461380754942955 2232 2829099
SGTC_2805 7950783 58.44 µM 0.0966775582677356 0.459479059170913 no 1511 0.461491231120117 2157 1178958 YDL195W SEC31
SGTC_2394 5221648 200 µM 0.0966387720937612 0.459496619271165 no 1512 0.461506632450721 2174 788586
SGTC_2435 5706476 10.6 µM 0.0962672051895755 0.459664846929158 no 1513 0.461654178276614 2234 5725375
SGTC_3341 9147222 25.867 µM 0.09585272085849 0.459852514057748 no 1514 0.461818772447426 2153 1939759
SGTC_1853 st056710 91.2 µM 0.0957156337067507 0.459914585327878 no 1515 0.461873212003828 2263 269167
SGTC_1743 st037606 46.3785 µM 0.0947203077641073 0.460365285106203 no 1516 0.462268493618329 2178 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_3180 9109287 49.47 µM 0.0944559147550994 0.460485015146073 no 1517 0.462373500372673 2179 18891271
SGTC_3186 9110464 49.47 µM 0.0940981876883445 0.460647017097016 no 1518 0.462515580005162 2223 17018021
SGTC_1616 st002734 56.1 µM 0.0937842361421351 0.460789200043936 no 1519 0.462640277111776 2142 4026101
SGTC_2897 9048598 12.99 µM 0.0936828612471017 0.460835111962236 no 1520 0.462680542568748 2195 6467404
SGTC_1771 st048882 4.1505 µM 0.0935561363576952 0.460892505434174 no 1521 0.462730877418364 2145 4580403
SGTC_2307 7538926 6.34 µM 0.0934652002440247 0.460933690736765 no 1522 0.462766997412142 2136 96582
SGTC_968 1309-0633 340 µM 0.0933784653355549 0.460972973688418 no 1523 0.462801448965442 2245 3761976
SGTC_2292 7671323 168.05 µM 0.0922395708352131 0.461488823540155 no 1524 0.463253849529315 2138 937504
SGTC_3316 9136639 10.545 µM 0.0907916393552044 0.462144741771556 no 1525 0.463829076720909 2178 4903665
SGTC_2689 tacrolimus 100 µM 0.0903223984120074 0.462357331803943 no 1526 0.464015510768729 2151 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_20 0481-0013 4.944 µM 0.0903206182687085 0.462358138319983 no 1527 0.464016218052263 2190 182045
SGTC_505 gw-5074 63.9 µM 0.0898678713178912 0.462563265967411 no 1528 0.464196106393831 2217 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_618 k072-0232 33.2 µM 0.0896646756266038 0.462655331791502 no 1529 0.46427684379961 2192 5872756 YGL099W LSG1
SGTC_2468 5987765 72.9 µM 0.0887689857941665 0.463061183184724 no 1530 0.4646327530544 2167 26772094
SGTC_2982 9019404 25.97 µM 0.0872916650168405 0.463730664680797 no 1531 0.465219839542459 2068 22333232
SGTC_1708 st033234 31.827 µM 0.0869916000609873 0.463866658549557 no 1532 0.465339094488095 2223 674664
SGTC_1750 st081859 2.357 µM 0.0859567928088942 0.464335680763456 no 1533 0.465750382195527 2194 5291695
SGTC_2253 7938677 135.83 µM 0.0846306599283412 0.464936817513169 no 1534 0.466277511702154 2256 2301972
SGTC_1063 disulfiram 1.84 µM 0.0828157198738153 0.465759660268562 no 1535 0.466999034707096 2271 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3137 9097352 49.47 µM 0.0814717412234857 0.466369076919756 no 1536 0.467533398694757 2206 44120435
SGTC_227 fluconazole 33.516 µM 0.0814477510221163 0.466379955810354 no 1537 0.467542937698899 2136 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1096 rimcazole 32.2 µM 0.0798624599276596 0.467098896615237 no 1538 0.468173323531736 2171 18528119 A dopamine reuptake inhibitor.
SGTC_2272 7805186 180 µM 0.0788493186368439 0.467558419782814 no 1539 0.46857623776469 2282 2956062 YPR165W RHO1
SGTC_2399 5884133 200 µM 0.0788042834978835 0.467578847053259 no 1540 0.468594148453687 2191 722445
SGTC_1396 3511-0007 98.6 µM 0.0783305018279883 0.46779375254846 no 1541 0.468782577522528 2204 X1396
SGTC_249 wiskostatin 11.211 µM 0.078072749693139 0.467910671845857 no 1542 0.468885091804215 2263 2775510 A n-wasp and actin depolymerizer.
SGTC_801 0866-0028 10.1 µM 0.0773179053125426 0.468253093721885 no 1543 0.469185323582556 2268 6849771
SGTC_174 3553-0389 74.3 µM 0.0745686929249358 0.469500422252437 no 1544 0.470278942087595 2232 738071
SGTC_1085 doxorubicin 7.67 µM 0.0743991876894603 0.469577337371456 no 1545 0.470346377571784 2285 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_953 1188-0045 9.7 µM 0.074005798163886 0.469755847154984 no 1546 0.470502885823564 2213 6144426
SGTC_2649 anisomycin 9.56 µM 0.0733578052886778 0.470049902455272 no 1547 0.470760696794781 2209 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2088 5278280 127.392 µM 0.0730987816065821 0.470167450435204 no 1548 0.470863755601746 2217 791502
SGTC_2449 5812982 45.77 µM 0.0728172635111703 0.47029520959117 no 1549 0.470975766565213 2275 776185
SGTC_2427 5545055 42.75 µM 0.0728120640595879 0.470297569246426 no 1550 0.470977835354673 2220 5372858
SGTC_2846 9008642 19.48 µM 0.0716386657382145 0.4708301164501 no 1551 0.471444734151008 2157 2992898
SGTC_274 sirtinol 40.1 µM 0.0709336645741535 0.471150106603615 no 1552 0.471725275195794 2120 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1886 st057356 49.9 µM 0.0699385639665736 0.47160180048399 no 1553 0.472121279328703 2210 24207747
SGTC_337 1315-0038 354 µM 0.0698469903508592 0.471643369222709 no 1554 0.472157722793803 2190 1626437
SGTC_1036 k216-0215 33.5 µM 0.0694767439460127 0.471811441258748 no 1555 0.472305071778136 2300 622330
SGTC_535 2293-4129 48.2 µM 0.0693805064051138 0.471855128770688 no 1556 0.472343372579488 2280 396118 YIL048W NEO1
SGTC_2694 st077685 81.9 µM 0.0688815284814117 0.47208164770717 no 1557 0.472541960864374 2254 2838096
SGTC_3143 9086658 49.47 µM 0.0686302627118591 0.472195717208687 no 1558 0.472641964745788 2146 25236626
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.0685598353714777 0.472227690185123 no 1559 0.472669995166423 2210 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1521 st012942 49.4 µM 0.0683981064302971 0.472301113422158 no 1560 0.472734364575908 2274 24207259
SGTC_2345 9052315 157.45 µM 0.0675848704756436 0.472670328201665 no 1561 0.47305804973517 2211 6469265
SGTC_1153 4055-0057 267 µM 0.0669340064829844 0.472965841914664 no 1562 0.473317120237112 2190 882706
SGTC_504 lovastatin 124 µM 0.0655013893844165 0.473616349506655 no 1563 0.473887400072333 2170 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_531 3788-1495 174 µM 0.0649743036322537 0.473855700817485 no 1564 0.474097229871059 2252 2896655
SGTC_3041 9091929 49.47 µM 0.0647228714254178 0.473969880309868 no 1565 0.474197326117988 2254 25236887
SGTC_820 1582-0060 59.9 µM 0.0636294128300262 0.474466462556651 no 1566 0.474632655569257 2229 3848840
SGTC_2387 9077560 195.08 µM 0.0635594097692598 0.474498255039513 no 1567 0.474660526334768 2263 5303272
SGTC_2767 sibutramine 71.45 µM 0.0635484228412236 0.474503244860672 no 1568 0.474664900641835 2275 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_86 0417-1630 471.922 µM 0.0630041498188748 0.474750436784443 no 1569 0.474881599905496 2281 3634867
SGTC_1657 st012939 43.4 µM 0.0629900161296572 0.474756855997565 no 1570 0.474887227254177 2279 24207257
SGTC_1327 1436-0082 2.18 µM 0.0626928970604744 0.474891802507358 no 1571 0.475005526796666 2148 15992205
SGTC_439 amiodarone 34.4 µM 0.0622427146704915 0.475096273300036 no 1572 0.475184773512342 2229 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_330 1488-0319 80.1 µM 0.062154408968619 0.47513638211912 no 1573 0.475219934311977 2187 6846614
SGTC_3061 glucosamine 200 µM 0.0615364574628417 0.475417065305823 no 1574 0.475465990276201 2285 91431 and experimental redox chemotherapeutic
SGTC_3054 9094397 49.47 µM 0.0613606074976159 0.475496941331466 no 1575 0.475536011939201 2275 2598354
SGTC_1795 st049545 62.3 µM 0.0608376968885375 0.47573446791881 no 1576 0.475744234067035 2326 5291882
SGTC_2528 xanthyletin 44.79 µM 0.0602361480619411 0.476007725741832 no 1577 0.475983777991118 2246 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1233 0325-0408 14.2 µM 0.0600575300707064 0.476088866410314 no 1578 0.476054907482808 2261 12874
SGTC_171 k064-0041 9.68 µM 0.0592542101036549 0.476453802212248 no 1579 0.476374816018104 2215 53325
SGTC_2557 derrustone 83.84 µM 0.0588875265713575 0.476620387437336 no 1580 0.476520846582314 2131 629853 An antioxidant.
SGTC_1842 st055362 61.2 µM 0.0584153471806888 0.476834905703071 no 1581 0.476708895182372 2210 676032
SGTC_3017 9080681 49.47 µM 0.0578017303242231 0.477113691178331 no 1582 0.476953279942998 2223 16451914
SGTC_429 1112-0049 25.5 µM 0.057637811693216 0.477188166479511 no 1583 0.477018565173529 2158 2836170
SGTC_1350 1495-0454 146 µM 0.0574055816697582 0.477293679954787 no 1584 0.477111058403529 2293 1069057
SGTC_1338 1486-1223 76 µM 0.0569170455234089 0.477515651044314 no 1585 0.477305637979884 2256 3444526
SGTC_3299 9121982 43.1275 µM 0.056822126498215 0.477558779226392 no 1586 0.477343444007599 2243 17594604 YPL160W CDC60
SGTC_468 gf-109203x 121 µM 0.0564013542526247 0.477749967892099 no 1587 0.477511039068461 2306 2396 A protein kinase C inhibitor.
SGTC_1955 wogonin 32.4 µM 0.0562774517085598 0.477806267169961 no 1588 0.477560390645602 2272 5281703 A flavanone.
SGTC_670 4204-0025 119 µM 0.0558649083684916 0.477993723263624 no 1589 0.477724713109109 2278 719039
SGTC_2252 omeprazole 400 µM 0.0557069518373783 0.478065498624176 no 1590 0.477787630669635 2255 4594 A proton pump inhibitor.
SGTC_1106 tegaserod maleate 11.7 µM 0.0544121929183838 0.478653862968771 no 1591 0.478303382351403 2216 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_3267 9137951 49.47 µM 0.0543524707077732 0.478681003067803 no 1592 0.478327172860789 2193 16643986
SGTC_1935 st074532 41.6 µM 0.0537813242484724 0.478940559243559 no 1593 0.478554694536444 2287 2829742
SGTC_516 3992-2719 87.3 µM 0.053659168774314 0.47899607367687 no 1594 0.478603357252144 2295 5350887 YDR037W KRS1
SGTC_1652 st011932 78 µM 0.0533773821198391 0.479124135199863 no 1595 0.478715612985365 2309 1551076
SGTC_788 1182-0090 188 µM 0.0524335266330666 0.479553097933343 no 1596 0.479091630229579 2291 5715185
SGTC_772 k072-0172 35.3 µM 0.0518956667756279 0.479797554702759 no 1597 0.47930591351867 2218 5861980
SGTC_416 estradiol valerate 100 µM 0.0515139792707371 0.47997103590845 no 1598 0.47945798139716 2212 13791 A steroid.
SGTC_113 0099-0221 2.5 µM 0.0511108389244441 0.480154271787626 no 1599 0.479618599535066 2310 89219
SGTC_2341 7987486 176.74 µM 0.0502232433763437 0.480557717607262 no 1600 0.479972244694136 2311 1258686
SGTC_3286 9117135 37.221 µM 0.04975410593324 0.480770966428609 no 1601 0.480159169757342 2271 3438150
SGTC_1040 k898-0338 155 µM 0.049209511539008 0.481018521490244 no 1602 0.480376165669762 2322 20969351
SGTC_2969 9091408 28.7 µM 0.048404241763365 0.481384584566516 no 1603 0.480697039415575 2127 4286311
SGTC_1013 4112-3890 241 µM 0.0482704706768123 0.481445396344044 no 1604 0.480750344048329 2220 705171
SGTC_425 3825-7017 13.1 µM 0.0475234412407398 0.481785000705308 no 1605 0.481048024015715 2255 3397440
SGTC_541 4513-1321 94 µM 0.0469493710463211 0.482045985683569 no 1606 0.4812767895229 2211 747515
SGTC_2772 vinpocetine 57.06 µM 0.0467971195335345 0.482115203876502 no 1607 0.481337462399701 2298 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_49 0717-0965 32.132 µM 0.0463172255718627 0.482333381862626 no 1608 0.481528705011028 2286 5889349 YGL099W LSG1
SGTC_665 3914-0008 307 µM 0.0461002191615797 0.482432042943854 no 1609 0.481615185664998 2305 1069549
SGTC_1277 0873-0036 22 µM 0.0458107948501888 0.482563630202363 no 1610 0.481730527399456 2302 5965735
SGTC_1311 1190-0148 100 µM 0.0455061216602833 0.482702152441493 no 1611 0.481851947787934 2307 1961333
SGTC_2940 9060638 45.86 µM 0.0444931442795229 0.483162726083311 no 1612 0.482255658319725 2259 4027022
SGTC_2036 5160441 105 µM 0.043708753650426 0.483519382928456 no 1613 0.482568280741463 2290 134534 YIL048W NEO1
SGTC_1843 st055809 45.5 µM 0.0436496241220196 0.483546269242934 no 1614 0.482591847518443 2254 16413835
SGTC_1017 4239-0030 168 µM 0.0421850377179768 0.484212243169708 no 1615 0.483175595057059 2263 1149593
SGTC_2740 felodipine 17.08 µM 0.0415210454165589 0.484514187100461 no 1616 0.483440257751768 2341 3333 L-type calcium channel blocker
SGTC_2455 5377712 9.75 µM 0.0402463042157366 0.485093887791508 no 1617 0.483948381043815 2201 2243908
SGTC_3236 9132701 49.47 µM 0.0397636700710946 0.485313378549737 no 1618 0.484140770196897 2293 24282524
SGTC_117 lucigenin 22.078 µM 0.0393503682747825 0.485501342111517 no 1619 0.484305524805875 2252 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_3255 9139072 49.47 µM 0.0390689274405328 0.48562933909862 no 1620 0.484417717178484 2262 17646060
SGTC_3223 9129970 49.47 µM 0.0385809938919428 0.485851250782476 no 1621 0.484612227843348 2330 17248386
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.0381281206418398 0.48605722100019 no 1622 0.484792765288291 2331 6710655
SGTC_887 0885-0007 9.62 µM 0.0377877613197986 0.486212021474153 no 1623 0.484928451228001 2324 5719458
SGTC_2171 5739187 198.077 µM 0.0374788341902736 0.486352527919538 no 1624 0.485051608078781 2335 2262761
SGTC_2228 7354201 200 µM 0.0372209040393319 0.486469841183252 no 1625 0.485154435573246 2286 753451
SGTC_1651 st011928 86.1 µM 0.0370173097446505 0.486562441930009 no 1626 0.48523560200934 2316 720198
SGTC_2890 9046729 58.44 µM 0.0362121122210056 0.486928676787568 no 1627 0.485556614084452 2292 903329
SGTC_1073 triclabendazole 3.09 µM 0.0347310949175675 0.487602329080682 no 1628 0.486147082859855 2288 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1583 clindamycin 39.6 µM 0.0345413336610418 0.487688646067998 no 1629 0.486222741252087 2254 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_184 1494-0393 24.714 µM 0.0331824061593438 0.488306800068784 no 1630 0.486764564123626 2319 3090647
SGTC_1757 st041620 31.8375 µM 0.0327161770820272 0.488518886634166 no 1631 0.486950461675465 2300 5289815
SGTC_722 3534-0461 190 µM 0.0324884270016025 0.488622490820866 no 1632 0.487041272536997 2327 658262
SGTC_619 1652-1634 108 µM 0.0323255789918423 0.488696571334385 no 1633 0.487106205387655 2314 5400454
SGTC_1130 3454-2858 15.9 µM 0.0303365441525905 0.489601425633065 no 1634 0.487899325978367 2241 715628 YIL048W NEO1
SGTC_2212 7123476 200 µM 0.03019277180181 0.489666832866587 no 1635 0.487956656585813 2340 1085715
SGTC_848 0368-0089 85.6 µM 0.028888490788896 0.490260209871685 no 1636 0.488476762406138 2355 762535
SGTC_1255 0566-0045 221 µM 0.0288201235977106 0.490291313835611 no 1637 0.488504025617646 2317 2788469
SGTC_1260 0700-1617 7.75 µM 0.0287195474461586 0.490337071519503 no 1638 0.4885441330949 2317 2853078
SGTC_2507 purpurin 79.67 µM 0.0279699029559664 0.490678130447782 no 1639 0.488843077856571 2364 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_3242 9133940 49.47 µM 0.0273151104764043 0.490976041005659 no 1640 0.489104202474106 2355 17248444
SGTC_1958 st076513 41.9 µM 0.0267985278194745 0.491211073880505 no 1641 0.489310213713711 2349 732122 YGL099W LSG1
SGTC_1220 1838-0075 193 µM 0.0267189844956002 0.491247264482227 no 1642 0.489341935549777 2323 5529645
SGTC_2523 spermine 47.74 µM 0.0262159936664716 0.491476116780781 no 1643 0.489542529582884 2357 1103 A DNA binding polyamine.
SGTC_2099 5377090 177.372 µM 0.0247996926878823 0.492120524539821 no 1644 0.490107368091824 2331 2243829
SGTC_1468 k284-1086 134 µM 0.024484733376723 0.492263831837917 no 1645 0.490232980532977 2347 15996457
SGTC_1442 4112-3290 3 µM 0.0237475347190138 0.49259926299806 no 1646 0.490526994729951 2365 704353
SGTC_1131 3454-3128 32.3 µM 0.0233089588116817 0.492798820967093 no 1647 0.490701912779022 2307 710982
SGTC_3270 9137563 49.47 µM 0.0231062807352922 0.492891042844733 no 1648 0.490782747861305 2340 17015724
SGTC_1612 st002233 45.4 µM 0.0227703514926052 0.493043897041825 no 1649 0.49091672898599 2360 1035021
SGTC_2355 9061122 103.12 µM 0.0226229709294403 0.493110958325928 no 1650 0.490975510181716 2351 5302957
SGTC_334 1502-1024 68.5 µM 0.0223501534785856 0.493235096568453 no 1651 0.491084321084008 2302 3296216
SGTC_588 3970-1144 52.9 µM 0.0220657816209972 0.493364493030135 no 1652 0.491197741068507 2357 1888707
SGTC_758 0868-0029 16 µM 0.0220186399205294 0.493385943776279 no 1653 0.491216543317816 2374 762687
SGTC_2757 clomiphene 4.22 µM 0.0219490998304389 0.493417586429168 no 1654 0.491244279096901 2374 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2709 st078560 56 µM 0.0216983616083219 0.493531679556359 no 1655 0.491344285356666 2362 17250903
SGTC_521 r062-0005 13.8 µM 0.0209580482380729 0.493868546556821 no 1656 0.49163956048723 2362 2832033
SGTC_456 gingerol 170 µM 0.018852737460284 0.494826555489449 no 1657 0.492479291437287 2350 442793 A herb.
SGTC_359 0081-0058 15.9 µM 0.0187628991911513 0.494867436553311 no 1658 0.492515125382826 2365 3494159
SGTC_1801 st050089 28.441 µM 0.0181695831381521 0.495137427409928 no 1659 0.492751783884579 2360 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2794 7785382 27.27 µM 0.0181103523806089 0.495164380728727 no 1660 0.492775409650611 2384 2205081
SGTC_2044 5102272 200 µM 0.0174740754959095 0.495453923787125 no 1661 0.493029207223055 2353 592666
SGTC_738 1315-0003 72.4 µM 0.016150719146047 0.496056135532785 no 1662 0.493557075376532 2371 6251474
SGTC_777 1315-0167 517 µM 0.0154176023030656 0.496389754523249 no 1663 0.493849510244283 2303 4221767
SGTC_3114 9122766 49.47 µM 0.0150976104146706 0.496535373822764 no 1664 0.493977153679192 2312 17176985
SGTC_2661 dactinomycin 12.96 µM 0.0146503262233009 0.496738921034941 no 1665 0.494155574515445 2377 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1285 0929-0069 65.5 µM 0.0144745072856705 0.496818931821316 no 1666 0.49422570868641 2375 1206237
SGTC_3189 9110682 49.47 µM 0.0144729929589192 0.496819620953979 no 1667 0.494226312752102 2365 17122418
SGTC_1794 st048918 76.9 µM 0.0139237187798277 0.497069582661898 no 1668 0.494445419356594 2371 672303
SGTC_972 1319-0219 195 µM 0.0128765081029879 0.497546146616729 no 1669 0.494863158446053 2369 23903702
SGTC_1368 1852-0141 284 µM 0.0127419917348907 0.497607362506289 no 1670 0.4949168183103 2352 2838987
SGTC_1797 st048695 56.8 µM 0.0126401356460276 0.497653715349643 no 1671 0.494957449738403 2383 592262 YIL048W NEO1
SGTC_1607 st000305 50.6 µM 0.0121857181162653 0.497860512834396 no 1672 0.495138722136589 2382 5457690
SGTC_1332 1480-0653 17.5 µM 0.0109086790743674 0.498441673906775 no 1673 0.495648153005185 2387 5749438
SGTC_2179 6298986 200 µM 0.00878819320166993 0.499406681526511 no 1674 0.496494063292191 2386 738374
SGTC_1065 prochlorperazine maleate 2.48 µM 0.00814608723047295 0.499698897175669 no 1675 0.496750217325878 2391 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_3249 9135183 49.47 µM 0.00808118901950637 0.499728431677991 no 1676 0.49677610711396 2382 4902779
SGTC_2634 4'-methoxyflavone 100 µM 0.00782525598449082 0.499844904159211 no 1677 0.496878206393168 2377 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2497 7-hydroxyflavone 100 µM 0.00764277331914554 0.499927950144368 no 1678 0.496951004266479 2382 5281894
SGTC_1911 st060208 74.3 µM 0.00732613310629129 0.499927950144368 no 1679 0.497077321896515 2392 688783
SGTC_841 0251-0215 91.2 µM 0.00551841137577487 0.499105275282244 no 1680 0.497798483555308 2372 3888614
SGTC_700 3453-2283 142 µM 0.00489016872084469 0.498819369469224 no 1681 0.498049112714467 2391 565664
SGTC_1993 st073995 70.8 µM 0.00488875252279291 0.498818724974845 no 1682 0.498049677688994 2380 3098394
SGTC_68 0986-0284 82.829 µM 0.00483130469410313 0.498792581174605 no 1683 0.498072595786109 2364 423278 YIL048W NEO1
SGTC_513 4245-1575 41.7 µM 0.00365862807181646 0.498258911759536 no 1684 0.498540421830101 2391 719745
SGTC_2285 7945142 200 µM 0.0029759702134866 0.497948244690443 no 1685 0.498812761409068 2393 2970608
SGTC_2875 9039966 71.43 µM 0.00279606821873517 0.497866374265027 no 1686 0.498884531622115 2387 6463691
SGTC_1247 0448-0043 5.84 µM 0.00268152995798173 0.497814249841593 no 1687 0.498930225605652 2399 3089013 YGL099W LSG1
SGTC_1015 4130-4525 82 µM 0.00252728822693008 0.497744057100093 no 1688 0.498991758944821 2402 1363237
SGTC_534 k292-0788 63.4 µM 0.00250051664073585 0.49773187382175 no 1689 0.499002439228719 2402 4146317
SGTC_1675 st018485 24.5 µM 0.00242247602337377 0.497696358920531 no 1690 0.499033572836246 2384 3323024
SGTC_2753 fluvastatin 17.09 µM 0.0019504587795876 0.4974815526415 no 1691 0.499221880020008 2398 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1994 st072947 40.9 µM 0.00163971414549496 0.497340138925894 no 1692 0.499345848992722 2393 5286565 YDL195W SEC31
SGTC_1754 st042065 16.137 µM 0.00162067584554566 0.497331474984126 no 1693 0.499353444165426 2399 1126236 YIL048W NEO1
SGTC_105 0111-0055 734.78 µM -0.000133366615196435 0.496533251989596 no 1694 0.499946794418562 2407 5179370
SGTC_138 0850-0259 40.9225 µM -0.000321779831177168 0.496447510386379 no 1695 0.499871628422578 2406 6813004
SGTC_2376 9072922 81.32 µM -0.000667587235480815 0.496290143504745 no 1696 0.499733671245693 2413 17087968
SGTC_410 α-linolenic acid 100 µM -0.00136556090427621 0.495972517793138 no 1697 0.499455220188135 2417 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2452 5863136 48.41 µM -0.00158197030405955 0.495874037238173 no 1698 0.499368885422612 2407 2184096
SGTC_1077 5-fluorocytosine 377 nM -0.00172340059067032 0.49580967726209 no 1699 0.499312462978656 2412 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1939 st074455 53.6 µM -0.00265196428377618 0.495387123193236 no 1700 0.498942020561201 2410 1644229
SGTC_1837 st055472 66.5 µM -0.0030928022731872 0.495186516350499 no 1701 0.498766152375351 2423 676091
SGTC_486 niguldipine 82 µM -0.00356712934487813 0.494970671394671 no 1702 0.498576924302635 2413 1236 A calcium channel blocker.
SGTC_1150 3909-7983 10.9 µM -0.00362771558147376 0.494943101423083 no 1703 0.49855275404765 2419 23965914
SGTC_2259 7964009 200 µM -0.00365309868248477 0.494931550764411 no 1704 0.498542627722549 2423 313134
SGTC_2444 5485484 36.41 µM -0.00426031724438394 0.494655235367308 no 1705 0.498300384464716 2416 6790631
SGTC_3322 9139058 2.11 µM -0.00449228751361221 0.494549677740422 no 1706 0.498207842602919 2455 4908926 YPR165W RHO1
SGTC_79 0052-0007 94.094 µM -0.00452072609391772 0.494536736845014 no 1707 0.498196497366044 2411 2801472
SGTC_595 3909-8003 73.7 µM -0.004772765941024 0.494422047079385 no 1708 0.498095949100491 2419 699517
SGTC_2801 7907800 81.82 µM -0.00498299656200284 0.494326382794011 no 1709 0.498012080215085 2418 6620925
SGTC_2373 9071805 200 µM -0.00518782477682042 0.494233177157554 no 1710 0.497930366636738 2419 10149009
SGTC_2313 7726885 200 µM -0.00551663578369546 0.494083554685316 no 1711 0.497799191903279 2423 726423
SGTC_445 e6 berbamine 66 µM -0.00583695791102676 0.493937795801073 no 1712 0.49767140392295 2427 6610268 A calcium/calmodulin antagonist.
SGTC_1351 1496-0003 46.5 µM -0.00591242622617072 0.493903454933029 no 1713 0.497641296940746 2421 3891978
SGTC_2278 7948257 134.34 µM -0.00638094188709622 0.493690264040648 no 1714 0.497454389767154 2424 1247028
SGTC_1044 1222-0021 1.78 µM -0.00652415186708557 0.493625098884378 no 1715 0.497397258440563 2449 4306703
SGTC_1380 2291-0730 164 µM -0.00704405559631641 0.49338852737477 no 1716 0.497189851636477 2427 2999191
SGTC_59 0330-0160 1.33 µM -0.00713443374630503 0.49334740288951 no 1717 0.497153796877255 2425 4293482
SGTC_2771 fluoxetine 41.05 µM -0.0074021980814526 0.493225563343206 no 1718 0.497046977184695 2424 3386 A selective serotonin reuptake inhibitor.
SGTC_2868 9035608 32.47 µM -0.00746572314066261 0.493196657926559 no 1719 0.497021635052976 2413 6462614
SGTC_3300 9124615 50.48 µM -0.00754899262051154 0.493158768381857 no 1720 0.496988416272932 2424 24824903
SGTC_82 0054-0107 293.755 µM -0.00780526358771845 0.493042159536538 no 1721 0.496886181961956 2449 3104697
SGTC_3228 9131799 49.47 µM -0.00787493357865519 0.493010458282785 no 1722 0.496858388511107 2427 17015818
SGTC_2636 apigenin dimethyl ether 100 µM -0.00806859841277661 0.492922337102248 no 1723 0.496781129875566 2432 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_622 1348-1566 26.3 µM -0.00858150852701557 0.492688954931472 no 1724 0.496576515437873 2422 7340407
SGTC_741 4582-0002 126 µM -0.0086890737900085 0.492640011359436 no 1725 0.496533604706502 2426 2912688
SGTC_1123 mangostin 811.285 nM -0.00964951482612307 0.492203003387371 no 1726 0.496150460291044 2446 5281650 An antioxidant.
SGTC_2133 5320837 200 µM -0.0101581197179482 0.491971588052148 no 1727 0.495947566248599 2436 2841355
SGTC_2404 5161160 200 µM -0.0106695103113672 0.491738907946614 no 1728 0.495743561983488 2431 2831543
SGTC_2412 st077135 33.4 µM -0.0113838748002085 0.491413880479793 no 1729 0.49545858911649 2490 13258915
SGTC_1635 st007035 42.4 µM -0.0118943219195804 0.491181636504824 no 1730 0.495254963973749 2421 3716403
SGTC_1074 carmofur 3.8 µM -0.0120568902242177 0.491107671564342 no 1731 0.495190113254102 2417 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1780 st038448 24.544 µM -0.0123388660424605 0.490979379604003 no 1732 0.495077629546964 2468 728868 YDL195W SEC31
SGTC_891 0929-0073 133 µM -0.0127227410054167 0.490804727578309 no 1733 0.494924497617732 2462 5603632
SGTC_161 4065-0411 162.148 µM -0.0130326154812921 0.490663744922217 no 1734 0.494800885838163 2439 1906281 YLR208W SEC13
SGTC_1881 5652484 16 µM -0.0132291860017706 0.490574312428642 no 1735 0.494722472306933 2425 2255129
SGTC_718 1130-0073 349 µM -0.0138092780051335 0.49031039427928 no 1736 0.494491070231116 2441 6740020
SGTC_2122 5258151 111.688 µM -0.0145048998707664 0.489993920368755 no 1737 0.494213585071958 2446 2173356
SGTC_1196 1588-0294 184 µM -0.0147549032710599 0.489880182583258 no 1738 0.494113858818573 2461 6144269
SGTC_797 k781-0471 270 µM -0.0159416886126371 0.489340271962951 no 1739 0.493640455758944 2480 23738129
SGTC_2109 5483026 200 µM -0.0172872501648241 0.488728152110212 no 1740 0.493103728489748 2446 759335
SGTC_1455 4262-0120 131 µM -0.0172990977881663 0.488722762531691 no 1741 0.493099002678563 2482 1529587
SGTC_212 3807-4682 38.772 µM -0.0174027165550038 0.488675625614616 no 1742 0.493057670993449 2457 3125501 YBL034C STU1
SGTC_1433 4060-0023 7.6 µM -0.0176301242744956 0.488572176774314 no 1743 0.492966962356355 2456 3840627
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.0190032253943104 0.487947563206331 no 1744 0.49241926619131 2505 61125 An anti-inflammatory.
SGTC_1602 st001878 87.6 µM -0.0198833133122904 0.4875472331555 no 1745 0.492068228281268 2490 595405 YLR310C CDC25
SGTC_306 1672-3436 11.6 µM -0.0203256891117916 0.487346012147269 no 1746 0.491891781535154 2447 6797378
SGTC_1409 3909-8004 61.9 µM -0.0203555043961332 0.487332450350769 no 1747 0.491879889418004 2457 2119279
SGTC_1398 3558-0053 112 µM -0.0210141387142754 0.487032867349614 no 1748 0.491617188551771 2450 4532369
SGTC_1257 0669-0121 16 µM -0.0216804317778814 0.486729808177228 no 1749 0.491351436641822 2476 4307855
SGTC_2448 5185112 27.17 µM -0.0240065717693026 0.48567183937856 no 1750 0.490423683352501 2477 5718189
SGTC_2858 9025781 8.96 µM -0.0240852467162046 0.485636058369808 no 1751 0.490392305662474 2463 4894980 YPL153C RAD53
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.0246673381987458 0.485371329417782 no 1752 0.490160153745307 2440 66535 A nucleotide analog.
SGTC_2766 oltipraz 83.91 µM -0.0248827887910715 0.485273346431842 no 1753 0.490074227769747 2462 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.0255899971423715 0.484951727298916 no 1754 0.48979218229147 2440 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2517 totarol 10 µM -0.0267275127318749 0.484434436756629 no 1755 0.489338534490369 2485 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1660 st012960 28.1 µM -0.0268493739072239 0.484379021354501 no 1756 0.489289936355855 2480 24207266
SGTC_1369 1866-0067 208 µM -0.0268891806495127 0.484360919619764 no 1757 0.489274061494839 2416 3531355
SGTC_409 arachidonic acid 100 µM -0.0277330157538853 0.483977201331824 no 1758 0.488937545530374 2446 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2183 6420625 130.508 µM -0.0283333447843829 0.483704221905662 no 1759 0.488698142988378 2453 2897619
SGTC_1286 0929-0070 131 µM -0.028355566874973 0.483694117303531 no 1760 0.488689281217407 2498 1420408
SGTC_3199 9111318 49.47 µM -0.0286622053133859 0.483554686875875 no 1761 0.488566999882586 2486 8548020
SGTC_1773 st048542 73.5835 µM -0.0294066547223426 0.4832161894463 no 1762 0.488270132700199 2456 3237138
SGTC_1091 telmisartan 47.6 µM -0.0305133590475034 0.482712998946934 no 1763 0.487828819681679 2524 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1053 3366-3204 134 µM -0.030639047623105 0.482655853252916 no 1764 0.487778700628475 2481 3632071 YPR165W RHO1
SGTC_1283 0922-0125 16.4 µM -0.0307828249844453 0.482590483730411 no 1765 0.487721368803085 2481 3360884
SGTC_1210 3013-0140 750 nM -0.0308347305140218 0.482566884582855 no 1766 0.487700671317912 2469 905973
SGTC_3020 9089140 49.47 µM -0.0313118786560206 0.482349949307857 no 1767 0.487510408628128 2479 17217859
SGTC_877 0771-0151 33.1 µM -0.0322722045422032 0.481913353309025 no 1768 0.487127487608409 2529 6166523
SGTC_2020 4017018 200 µM -0.0328852554810259 0.48163465132946 no 1769 0.486883045429369 2495 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.0329846432118567 0.48158946904618 no 1770 0.486843416959949 2461 77254
SGTC_2060 5238662 140 µM -0.0342207831247776 0.481027532066216 no 1771 0.48635054685437 2504 790130
SGTC_3154 9100113 49.47 µM -0.0343248197606866 0.480980239744686 no 1772 0.486309066610633 2476 25237525
SGTC_2364 9055074 200 µM -0.0350290676979665 0.480660114206333 no 1773 0.486028281210005 2484 6470630
SGTC_2834 9001755 58.44 µM -0.0361428701161019 0.480153845615794 no 1774 0.485584219616554 2579 2989575
SGTC_558 k064-0027 21.3 µM -0.0369309697762059 0.479795641493206 no 1775 0.485270023136849 2512 5088526
SGTC_3043 9092303 49.47 µM -0.0384049118673117 0.479125754840163 no 1776 0.484682422384547 2490 25236084
SGTC_153 4077-0274 519.67 µM -0.0387800067206413 0.478955288662246 no 1777 0.484532892583932 2483 3121976
SGTC_2143 5623677 140.463 µM -0.0393649358822776 0.478689468558708 no 1778 0.484299717670761 2461 5375313
SGTC_3161 9100388 49.47 µM -0.0401773833587406 0.478320268879993 no 1779 0.483975854266689 2479 25236368
SGTC_168 3970-0862 530.542 µM -0.0405428232225399 0.478154208462041 no 1780 0.483830183547495 2517 3135186
SGTC_671 0560-0003 407 µM -0.040634438563717 0.478112577905333 no 1781 0.483793664408261 2541 3238678
SGTC_1919 st067113 52.3 µM -0.0411070823817322 0.477897809543415 no 1782 0.483605264226794 2530 1268243
SGTC_2681 menadione 3.18 µM -0.0412736152322946 0.477822138890549 no 1783 0.483538883567799 2506 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_501 nsc-95397 161 µM -0.0417805201691929 0.477591811925011 no 1784 0.48333683205227 2501 262093
SGTC_1235 benzylparaben 21.5 µM -0.0419714522949344 0.477505058310353 no 1785 0.483260727912045 2505 7180
SGTC_475 α-linolenic acid 10 µM -0.0428779923884095 0.477093169326488 no 1786 0.482899396071434 2538 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_312 4092-0653 6.84 µM -0.0429411753396588 0.477064462885977 no 1787 0.48287421291548 2567 1148278
SGTC_786 4544-0069 423 µM -0.0430187766940098 0.477029205774246 no 1788 0.482843283035467 2593 748821 YLR208W SEC13
SGTC_685 1278-0033 54.9 µM -0.0430399714605094 0.477019576253836 no 1789 0.482834835371148 2473 3590572
SGTC_2663 amphotericin b 100 µM -0.0433073316635404 0.476898106358389 no 1790 0.482728273442482 2487 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1118 chelidonine 707.474 nM -0.0440825870984477 0.476545896343207 no 1791 0.482419286386641 2490 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2799 7812892 81.82 µM -0.0446195940741034 0.476301936853268 no 1792 0.482205262200142 2516 20205235
SGTC_2864 9034755 47.6 µM -0.0454537694001929 0.475922992968609 no 1793 0.481872811729042 2486 4930451
SGTC_2291 7917025 104.35 µM -0.0462168791849957 0.475576351351147 no 1794 0.481568694602841 2500 2964612
SGTC_292 k038-0015 474 µM -0.0467076126109946 0.475353446086102 no 1795 0.481373131491709 2536 46368540
SGTC_3200 9114385 49.47 µM -0.048332465623354 0.474615446456469 no 1796 0.48072564047691 2545 17018030 YLR208W SEC13
SGTC_76 0433-0009 400.328 µM -0.0483735276302044 0.474596797428165 no 1797 0.480709278244994 2616 2841569
SGTC_96 0929-0093 37.281 µM -0.0506023762104969 0.47358461147294 no 1798 0.479821184655493 2485 6991579
SGTC_2337 9009472 200 µM -0.0510452815090987 0.473383495199451 no 1799 0.479644719065091 2513 5742383
SGTC_1650 st011916 45.8 µM -0.0514126216199605 0.473216697024133 no 1800 0.479498363738321 2505 242528
SGTC_3037 9091026 49.47 µM -0.0516852344287275 0.473092914722083 no 1801 0.479389751366363 2511 25236398 YIL048W NEO1
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.0518567121866152 0.473015055031513 no 1802 0.479321433254303 2641 5282309
SGTC_2432 5630864 12.22 µM -0.0530091010743298 0.472491838306702 no 1803 0.478862328150946 2568 5714970
SGTC_355 1311-2252 105 µM -0.0535642863877026 0.472239785561322 no 1804 0.47864115548859 2518 5338538
SGTC_265 mycophenolic acid 32.932 µM -0.0536556647341117 0.472198301083053 no 1805 0.478604753151006 2580 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1500 4488-1866 171 µM -0.0551216592733511 0.471532801813545 no 1806 0.47802077038523 2542 2900003
SGTC_839 0122-0028 230 µM -0.0557079367787604 0.471266678865683 no 1807 0.477787238344102 2520 759448
SGTC_2729 fluphenazine 10.66 µM -0.0564854546867342 0.470913767928562 no 1808 0.477477541251669 2515 3372 An atypical antipsychotic.
SGTC_993 3909-8757 62.7 µM -0.057329740777783 0.470530577170619 no 1809 0.477141264795645 2553 4288324 YLR208W SEC13
SGTC_1329 1447-1697 50.6 µM -0.0582174765131725 0.470127695633528 no 1810 0.476787700043636 2621 2840515
SGTC_136 0097-0015 404.482 µM -0.0585806499271739 0.469962885257821 no 1811 0.476643061665896 2485 4861337
SGTC_1449 4112-4002 201 µM -0.0588511795287672 0.469840120568467 no 1812 0.476535321849877 2552 2059539
SGTC_1000 4048-0884 8.67 µM -0.0593900923253276 0.469595573771256 no 1813 0.476320702155109 2578 13040088
SGTC_524 r073-0010 27.8 µM -0.0596680168952714 0.469469462178737 no 1814 0.476210022575666 2506 2772106
SGTC_1568 digitonin 820 nM -0.060863099983371 0.468927214014585 no 1815 0.475734118443719 2520 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1841 st054148 70 µM -0.0617711497084049 0.468515240724577 no 1816 0.475372539398011 2569 675442
SGTC_1670 st016595 4.04 µM -0.063007182350753 0.467954519050472 no 1817 0.474880392499221 2506 597879
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.0631357635045803 0.467896192313289 no 1818 0.474829197968062 2503 6708561
SGTC_2007 4011539 71.82 µM -0.0644307230507934 0.46730881387235 no 1819 0.474313633692603 2526 45595301
SGTC_660 4031-1742 102 µM -0.0654536364529587 0.46684488262275 no 1820 0.473906409941444 2518 6738706
SGTC_761 k216-0224 480 µM -0.0661475724644843 0.466530181094348 no 1821 0.473630168204495 2522 1340404
SGTC_2580 diallyl disulphide 81.36 µM -0.0672016254880786 0.466052205792056 no 1822 0.473210595549791 2560 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_119 0121-0043 24.815 µM -0.0677500697032352 0.465803525301726 no 1823 0.472992295491736 2519 1092378
SGTC_1428 4049-0204 61.7 µM -0.0677990693081047 0.465781308110154 no 1824 0.472972792321964 2583 X1428
SGTC_684 1140-0066 328 µM -0.0685498160991671 0.465440921082341 no 1825 0.472673982896054 2548 6813534
SGTC_1826 st055655 41.6 µM -0.0685852726165998 0.465424845794652 no 1826 0.472659871004743 2566 676168
SGTC_1111 tnp00062 510.699 nM -0.0698441577660705 0.464854128784499 no 1827 0.472158850078606 2641 676306
SGTC_1704 st028805 70.8 µM -0.0708307471885308 0.464406907820581 no 1828 0.471766230277905 2544 2876101
SGTC_612 0302-0167 22.4 µM -0.0711177044119031 0.464276838533327 no 1829 0.471652038882212 2583 235821
SGTC_899 1083-0020 478 µM -0.071123935054086 0.464274014408388 no 1830 0.471649559494132 2675 767123
SGTC_872 0588-0139 234 µM -0.0723529348927005 0.463716988569723 no 1831 0.471160519545389 2558 2047100
SGTC_2443 5493264 126.67 µM -0.0724565697736612 0.463670020842483 no 1832 0.471119283440525 2599 5340055
SGTC_3010 9080089 71.4286 µM -0.0725685577633281 0.46361926802343 no 1833 0.471074723999076 2537 17027233
SGTC_3116 9124943 49.47 µM -0.0737390570704818 0.463088834768214 no 1834 0.470609010160472 2542 41905195 YPL160W CDC60
SGTC_2588 indole-3-carbinol 100 µM -0.0753177610559577 0.462373520175633 no 1835 0.46998094517026 2602 3712 Induces cell cycle arrest.
SGTC_2816 7982706 58.44 µM -0.0754195967245967 0.462327382340638 no 1836 0.469940433841 2624 2981853
SGTC_3015 9080845 49.47 µM -0.0763297359424644 0.461915055755692 no 1837 0.469578384492463 2618 5296973
SGTC_2028 5153890 36.43 µM -0.0775446759958587 0.461364707026208 no 1838 0.469095125969538 2544 2830968 YPR165W RHO1
SGTC_1645 Cervolide 78 µM -0.0779333431867602 0.46118866247211 no 1839 0.468940538016332 2602 23173 A fragrance.
SGTC_95 0471-0001 561.058 µM -0.0781259248979908 0.461101436516507 no 1840 0.468863942565148 2567 4015405
SGTC_2199 6590217 200 µM -0.0783288599904414 0.461009523233237 no 1841 0.468783230514638 2570 703109
SGTC_864 0469-0573 172 µM -0.0789866789295283 0.460711598478436 no 1842 0.468521609315848 2538 689425
SGTC_2350 9023895 38.85 µM -0.0798040975911552 0.460341422104026 no 1843 0.468196532657411 2625 2997209
SGTC_1180 1193-0155 285 µM -0.080636687095145 0.459964410792525 no 1844 0.467865444554863 2624 2921347
SGTC_3131 9127911 49.47 µM -0.0814831997393765 0.459581131738747 no 1845 0.467528842556565 2712 45595681
SGTC_2756 carbadox 75.1 µM -0.0823800850232452 0.459175086242685 no 1846 0.467172236032052 2583 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2147 5545932 89.7195 µM -0.083789516337667 0.458537082773759 no 1847 0.466611891729126 2575 797404
SGTC_1230 0170-0365 3.77 µM -0.0846148028737041 0.458163552015212 no 1848 0.466283815141752 2624 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_878 0828-0289 13.7 µM -0.0847333789072451 0.458109886657618 no 1849 0.466236679426303 2570 745350 YLR208W SEC13
SGTC_2825 7998094 58.44 µM -0.0856912598339065 0.457676395244438 no 1850 0.465855925107068 2629 2987815
SGTC_2949 9072542 2.23 µM -0.0859677407138091 0.457551282469626 no 1851 0.465746030720749 2625 16457352
SGTC_1554 st069299 38.7 µM -0.0864918855882221 0.457314108656596 no 1852 0.465537703131498 2620 24207999
SGTC_342 k048-0088 23.3 µM -0.0867297209940813 0.457206493935149 no 1853 0.465443175743628 2544 6820570
SGTC_377 3970-0964 33.1 µM -0.0868937379346728 0.457132282096791 no 1854 0.465377988549128 2558 16481235
SGTC_1588 farnesol 29.9 µM -0.0872461945864251 0.456972813045082 no 1855 0.465237910674811 2567 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.0897949838629674 0.455819820837185 no 1856 0.464225067192979 2653 5393153
SGTC_2892 9047358 58.44 µM -0.0917966016737253 0.454914612076775 no 1857 0.463429822067411 2614 6466771
SGTC_842 0271-0008 11.1 µM -0.0920441434256285 0.454802680318929 no 1858 0.463331483524094 2689 1221709
SGTC_958 1222-0007 33 µM -0.0921595897822886 0.454750479791442 no 1859 0.463285622020344 2679 7312461
SGTC_2850 9015429 58.44 µM -0.0927398305096413 0.454488128473511 no 1860 0.463055126588673 2616 6457570
SGTC_287 k060-0039 29.6 µM -0.0944581118977501 0.453711337828898 no 1861 0.462372627741135 2637 5861974
SGTC_897 1000-0139 31.4 µM -0.0944909110726959 0.453696511881494 no 1862 0.462359601027929 2556 6151020
SGTC_3170 9103054 49.47 µM -0.0945570047757913 0.45366663627221 no 1863 0.462333350986788 2634 16432970
SGTC_2531 methyl deoxycholate 70.07 µM -0.0951859543589027 0.453382352256279 no 1864 0.462083563063476 2597 16667744 Haematoxylin.
SGTC_3103 9120822 49.47 µM -0.0974825695410285 0.45234449050714 no 1865 0.461171587895077 2727 17141819
SGTC_687 k029-0044 34.9 µM -0.0995366352302826 0.451416514691864 no 1866 0.460356100803628 2599 5829338
SGTC_427 1354-0053 47.3 µM -0.099593650170353 0.451390760521988 no 1867 0.460333467595865 2833 6813657
SGTC_2536 dehydroabietamide 32.04 µM -0.0996390072125709 0.451370272477313 no 1868 0.46031546231294 2664 3983547
SGTC_102 gallobenzophenone 83.616 µM -0.099903371499677 0.451250860142252 no 1869 0.460210519837593 2644 70837
SGTC_237 nikkomycin 200 µM -0.100223488634415 0.451106270365608 no 1870 0.460083449332272 2654 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_943 3253-1379 105 µM -0.100983595764742 0.450762972936618 no 1871 0.459781741142589 2688 668464
SGTC_934 2950-0684 338 µM -0.101391397384072 0.450578807158362 no 1872 0.459619882587966 2782 1121253
SGTC_3282 9108498 15.4605 µM -0.101540824770844 0.450511327471538 no 1873 0.459560575765604 2677 16459645
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.101846872906 0.450373124126182 no 1874 0.459439109929671 2592 140250 A respiratory chain inhibitor.
SGTC_2242 6630449 61.2675 µM -0.103060277746404 0.449825241574157 no 1875 0.458957565431271 2770 691249 YDR170C SEC7
SGTC_1734 st037168 69.4 µM -0.103087505941878 0.449812948457825 no 1876 0.458946760502606 2688 708907
SGTC_48 0382-0018 55 µM -0.10406152764042 0.449373224233919 no 1877 0.458560260772941 2662 762596
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.10446224050619 0.449192339552828 no 1878 0.458401266001875 2700 521171
SGTC_2717 st081029 62.2815 µM -0.104630454159398 0.44911640983949 no 1879 0.458334524203899 2595 5292846
SGTC_2114 5491910 81.25 µM -0.105009896325404 0.448945140845239 no 1880 0.45818397800353 2687 2849228
SGTC_744 1594-0068 283 µM -0.106456221595906 0.44829239981687 no 1881 0.457610194035492 2606 668392
SGTC_2388 9080168 200 µM -0.107020701928519 0.448037682085719 no 1882 0.457386278155253 2585 15943073
SGTC_2926 9010726 65.15 µM -0.107453701614475 0.447842308574345 no 1883 0.457214526674422 2686 2994293
SGTC_894 0960-0238 55.9 µM -0.107949224090543 0.447618739722463 no 1884 0.457017985024596 2567 6741907 YDL195W SEC31
SGTC_1581 himbacine 57.9 µM -0.108437219925889 0.447398582988356 no 1885 0.456824438979748 2576 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2930 9013230 14.89 µM -0.109051015118324 0.447121695560148 no 1886 0.45658101367971 2657 2995857
SGTC_482 fipronil 114 µM -0.110582095549384 0.446431126770611 no 1887 0.455973873039374 2588 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2119 5528445 120.635 µM -0.11106505850883 0.446213327826651 no 1888 0.455782378271435 2709 791935
SGTC_2488 5268135 45.7 µM -0.111361644602671 0.446079586191229 no 1889 0.455664787000994 2708 1270356 YLR208W SEC13
SGTC_2051 5263410 176 µM -0.111726164702854 0.445915219005054 no 1890 0.455520266389936 2583 227584
SGTC_1266 0828-0227 32.9 µM -0.112331075691571 0.445642476744461 no 1891 0.45528045144408 2696 3913820
SGTC_1186 1319-0216 26 µM -0.113536585155017 0.445099013484529 no 1892 0.454802579914498 2763 4565136
SGTC_62 0180-0423 3.232 µM -0.11361349588644 0.445064344366962 no 1893 0.454772094229205 2638 30102 YGL099W LSG1
SGTC_688 0527-0193 473 µM -0.114947682150235 0.444462999152977 no 1894 0.45424329532736 2661 4007154
SGTC_2520 obtusaquinone 4.71 µM -0.115076826589077 0.444404797858578 no 1895 0.45419211378247 2730 5967872
SGTC_2884 9058502 51.95 µM -0.115365119648952 0.444274877665121 no 1896 0.454077862408142 2687 6471554
SGTC_2049 5262831 67.185 µM -0.115928752318199 0.444020892101042 no 1897 0.453854504134504 2646 763417
SGTC_1390 3413-2614 145 µM -0.117261161236285 0.44342057025362 no 1898 0.453326550745503 2658 3421432
SGTC_2258 7960471 200 µM -0.11731619355485 0.443395778018161 no 1899 0.45330474652019 2678 2974708
SGTC_1699 st031318 29.054 µM -0.117506542253616 0.443310027030032 no 1900 0.453229329996549 2711 5340658
SGTC_593 1203-0218 61.7 µM -0.118170336240287 0.443011012474572 no 1901 0.45296634674703 2717 3666956
SGTC_1287 0971-0001 34.6 µM -0.118765370150741 0.442742999361201 no 1902 0.452730622534101 2613 4665869
SGTC_1241 0364-0022 50.8 µM -0.119252119304112 0.442523778968763 no 1903 0.452537807988888 2701 4563895
SGTC_3203 9113543 49.47 µM -0.119840624792928 0.442258753417591 no 1904 0.452304699948562 2781 17018012
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.120416605947757 0.441999393053089 no 1905 0.452076568736731 2722 6708739 YPR165W RHO1
SGTC_936 3005-4620 401 µM -0.122996263460901 0.440838097551683 no 1906 0.45105502841375 2699 777207
SGTC_683 panaxydol 45 µM -0.123354593313334 0.44067682666606 no 1907 0.45091315583725 2697 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2102 5377816 72.7585 µM -0.123654848145959 0.440541700753133 no 1908 0.450794281575417 2753 1379702
SGTC_407 eburnamonine 100 µM -0.123946284947632 0.440410549905506 no 1909 0.450678902691971 2613 3195
SGTC_2788 5282734 71.43 µM -0.124277770084452 0.440261384664871 no 1910 0.450547673869338 2734 743706
SGTC_1060 3448-7350 82 µM -0.124372018643251 0.440218975233524 no 1911 0.450510363597927 2685 570178
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.124540603295811 0.440143118179617 no 1912 0.450443626913598 2622 4174840
SGTC_907 3448-6986 75.5 µM -0.125045395049938 0.439915993124313 no 1913 0.450243806149309 2720 590582
SGTC_1178 0988-0033 191 µM -0.125982842813527 0.439494252144849 no 1914 0.449872752903806 2751 5392207
SGTC_1315 1237-0019 3.69 µM -0.126130685903493 0.43942774643927 no 1915 0.449814238799736 2694 825140
SGTC_2576 guaiol 23.12 µM -0.126628193404339 0.439203960332662 no 1916 0.449617340724782 2783 227829
SGTC_756 0508-1999 28.3 µM -0.12681507821331 0.439119901844927 no 1917 0.449543380702254 2639 6753853
SGTC_2851 9015922 71.43 µM -0.127610855447255 0.438762001814995 no 1918 0.449228469985052 2750 2996893
SGTC_1701 st028638 40.4 µM -0.128590715167791 0.438321379674708 no 1919 0.448840756765699 2639 3490878
SGTC_698 k064-0052 127 µM -0.129378546830175 0.437967163895673 no 1920 0.448529061074082 2603 5088751
SGTC_1628 st004252 77.7 µM -0.129710976626485 0.437817715540532 no 1921 0.448397548924645 2769 692968
SGTC_1310 1188-0297 994 nM -0.129719793034889 0.437813752124361 no 1922 0.448394061153112 2680 1588352
SGTC_564 3555-0129 330 µM -0.130962380862885 0.437255209385023 no 1923 0.447902533379392 2632 563260
SGTC_946 3434-1334 87.4 µM -0.132613363690357 0.436513286852022 no 1924 0.447249581538419 2764 4047976
SGTC_1028 k015-0029 4.8 µM -0.133072159889381 0.436307151475559 no 1925 0.447068156245607 2632 4588309
SGTC_2769 toremifene 3.73 µM -0.134223709327002 0.435789841034375 no 1926 0.446612839109363 2797 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1408 3909-7976 48.8 µM -0.135199675970775 0.435351493594101 no 1927 0.446227001639938 2676 24152374
SGTC_431 k089-0097 107 µM -0.135971405197428 0.435004933927553 no 1928 0.4459219431682 2638 5499420
SGTC_2181 6316240 54.2555 µM -0.136291093140255 0.434861386593927 no 1929 0.44579558241389 2723 12779990
SGTC_2255 7941087 197.44 µM -0.136914819963759 0.434581343453301 no 1930 0.445549062258436 2760 935561
SGTC_752 1896-0090 130 µM -0.137066738289463 0.434513139575276 no 1931 0.445489021641951 2648 772567
SGTC_2273 7815444 169.05 µM -0.137874266220055 0.43415063189869 no 1932 0.445169894363854 2758 2824616
SGTC_682 0kpi-0099 17 µM -0.138389645672683 0.433919301634456 no 1933 0.444966239917353 2748 1714895 YML126C ERG13
SGTC_2688 kanamycin b 96.69 µM -0.1385742579086 0.433836443146397 no 1934 0.444893293114811 2740 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_3231 9132313 49.47 µM -0.139235184755675 0.433539826868566 no 1935 0.444632152934675 2698 4905967
SGTC_3281 9140613 49.47 µM -0.140363284017733 0.433033635595539 no 1936 0.44418648286316 2690 16013766
SGTC_2224 6650123 117.647 µM -0.140663237812629 0.432899061289428 no 1937 0.444067994124855 2648 2908370
SGTC_453 enantio-paf c16 10 µM -0.141514323539891 0.432517263990748 no 1938 0.443731822682215 2704 13871343 A lipid and platelet activating factor
SGTC_2795 7780010 54.55 µM -0.142071552379525 0.432267325079292 no 1939 0.443511744064846 2775 953673
SGTC_1790 st045711 43.5 µM -0.142156827069831 0.432229078436879 no 1940 0.443478066194963 2685 585119
SGTC_2349 9023730 187.07 µM -0.14270278708062 0.431984224393719 no 1941 0.443262457738238 2765 4126287
SGTC_214 4373-3496 70 µM -0.142762826110478 0.431957299473701 no 1942 0.443238748376315 2689 3779166
SGTC_1307 1187-1599 12.2 µM -0.144083527690587 0.431365101836397 no 1943 0.442717255994434 2652 1538471
SGTC_2596 sinensetin 100 µM -0.144635647850855 0.431117578869387 no 1944 0.442499275122984 2713 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.145590091332798 0.43068975274811 no 1945 0.442122495302466 2709 688788
SGTC_3072 9116419 49.47 µM -0.145868343899094 0.430565042248933 no 1946 0.442012661078488 2743 17170162
SGTC_1136 pergolide 1.05886 µM -0.146883575086398 0.430110082841209 no 1947 0.441611958240459 2682 47811 A dopamine receptor agonist.
SGTC_137 0438-0332 85.389 µM -0.147174689917089 0.429979641535979 no 1948 0.441497068777213 2658 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1782 st039423 80.636 µM -0.147733198881859 0.429729408985945 no 1949 0.441276665093453 2703 2068169
SGTC_1467 k284-1082 293 µM -0.14819607997192 0.429522042626531 no 1950 0.441094012694559 2756 3334705
SGTC_2844 9010103 25.97 µM -0.148377934611734 0.429440578781502 no 1951 0.441022256467956 2849 2480525
SGTC_1109 tnp00067 928.257 nM -0.148968586092442 0.429176010508064 no 1952 0.440789210501343 2685 676295
SGTC_2054 5233173 129 µM -0.150502618127145 0.428489026262988 no 1953 0.440184042649569 2795 6889
SGTC_1226 3909-7979 35.4 µM -0.152732057541864 0.427491005061156 no 1954 0.439304789542422 2805 6615510
SGTC_1094 duloxetine 25.4 µM -0.153980547530201 0.426932313617108 no 1955 0.438812536737166 2660 60834 A selective serotonin reuptake inhibitor.
SGTC_2623 humulene 100 µM -0.154512018345822 0.426694528162318 no 1956 0.43860301787192 2733 6187145 An anti-inflammatory.
SGTC_2653 dihydrofissinolide 100 µM -0.155637549495991 0.426191042113531 no 1957 0.43815936268367 2718 6857746
SGTC_1513 0337-0559 19 µM -0.155725962439636 0.426151497263317 no 1958 0.438124515879096 2700 775073
SGTC_162 k030-0015 37.8 µM -0.156361077077665 0.425867448565961 no 1959 0.437874207875161 2778 1809920 YMR134W ERG29
SGTC_1062 mesoridazine 14.2 µM -0.156425594057797 0.425838596138605 no 1960 0.437848782175099 2667 4078 A neuroleptic.
SGTC_1108 betulinic acid 729.144 nM -0.156624964122405 0.425749439014908 no 1961 0.437770213419999 2707 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1640 st009078 66.4 µM -0.156835212069319 0.425655421478334 no 1962 0.437687360512352 2812 690618
SGTC_146 3448-8650 53.125 µM -0.157133881708296 0.425521871277071 no 1963 0.437569667756433 2727 2891488 YIL048W NEO1
SGTC_77 0828-0286 12.516 µM -0.157183044593362 0.425499888899703 no 1964 0.437550295324023 2650 745345
SGTC_3023 9089636 49.47 µM -0.158544764655108 0.424891110391433 no 1965 0.437013774800313 2658 17249241
SGTC_1076 itraconazole 331 nM -0.158547665861033 0.424889813552071 no 1966 0.437012631842469 2673 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2905 7799065 20.05 µM -0.158650531962666 0.424843832919008 no 1967 0.436972107096964 2790 1296806
SGTC_3145 9085516 49.47 µM -0.159593084193155 0.424422564472422 no 1968 0.436600813583748 2756 25236195
SGTC_234 nsc-17383 10.7 µM -0.160906342398443 0.423835755087608 no 1969 0.436083583444349 2731 408974
SGTC_2880 9042983 58.44 µM -0.161364596622889 0.423631030854174 no 1970 0.435903124509553 2832 6464714
SGTC_396 dithiazanine 1.25 µM -0.162186041192445 0.423264103626951 no 1971 0.435579675890504 2721 10578 An antihelmenthic.
SGTC_1473 k844-0725 134 µM -0.162191953939195 0.423261462730638 no 1972 0.435577347867718 2712 54682906
SGTC_3122 9126309 49.47 µM -0.162269211074985 0.423226956566227 no 1973 0.435546929659921 2678 17591206
SGTC_1146 3579-1023 7 µM -0.163083021796373 0.422863511575402 no 1974 0.435226533736901 2814 X1146
SGTC_297 0986-0032 24 µM -0.164572528856637 0.42219847322956 no 1975 0.434640227571898 2683 2847425
SGTC_2854 9024559 71.43 µM -0.16619563592914 0.42147403739916 no 1976 0.434001496856452 2784 3163529
SGTC_2321 7390090 138.78 µM -0.167235326566326 0.421010135289193 no 1977 0.433592444613689 2798 649046
SGTC_3032 9089427 49.47 µM -0.167735735215459 0.420786895777538 no 1978 0.433395590912752 2805 17173707
SGTC_2365 9042475 200 µM -0.168726325491649 0.420345054357441 no 1979 0.433005955449927 2785 6464479
SGTC_1685 st024049 53.0905 µM -0.169711810868216 0.419905589493949 no 1980 0.432618392545796 2782 1941139
SGTC_3046 9092212 49.47 µM -0.170598750588098 0.419510155190115 no 1981 0.432269640204803 2684 25236637
SGTC_3102 9121669 49.47 µM -0.171006519902367 0.41932838206053 no 1982 0.432109319486508 2739 41905072
SGTC_911 3456-4043 236 µM -0.171170494064904 0.419255291424439 no 1983 0.432044853696411 2804 914281
SGTC_1458 k015-0034 6.33 µM -0.173629461824101 0.418159554794794 no 1984 0.431078338253278 2770 3598957
SGTC_3090 9117696 49.47 µM -0.17366276444867 0.418144719204816 no 1985 0.431065251229472 2813 7923821
SGTC_1102 cgs 12066b 26.1 µM -0.174083170013408 0.41795744775354 no 1986 0.43090004981372 2770 6438352 A 5-HT1B full agonist.
SGTC_3295 9122362 53.5725 µM -0.177557591653872 0.416410467728449 no 1987 0.42953521609017 2803 4730473
SGTC_2814 7977482 42.97 µM -0.178693237889994 0.415905102676211 no 1988 0.429089289553713 2874 6456762
SGTC_122 0236-0016 402.397 µM -0.17877834266158 0.415867236456734 no 1989 0.429055875675485 2747 6808838
SGTC_2929 9013348 24.6 µM -0.178786259289185 0.415863714099834 no 1990 0.429052767471014 2828 2995952
SGTC_1852 st056254 31.4 µM -0.180448609821425 0.415124232150506 no 1991 0.428400197736021 2755 442583
SGTC_1733 st037357 54.9 µM -0.182419762215187 0.41424777212621 no 1992 0.427626658997827 2707 1272339 YGL099W LSG1
SGTC_1437 4092-1038 11.6 µM -0.183313383409707 0.413850569665135 no 1993 0.427276066943727 2747 3977136
SGTC_2012 4023501 200 µM -0.183361419016923 0.413829220983506 no 1994 0.427257222884228 2800 3477460
SGTC_1158 4092-0494 91.8 µM -0.184363446369034 0.413383943605544 no 1995 0.42686417191031 2858 1148199
SGTC_557 1315-0110 16.2 µM -0.186556760158578 0.412409676032024 no 1996 0.42600408591967 2736 6833801
SGTC_258 haloperidol 50.781 µM -0.187419658819017 0.412026524930374 no 1997 0.425665805092975 2756 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1411 3909-8223 150 µM -0.18778922486725 0.411862452908775 no 1998 0.425520941404221 2815 X1411
SGTC_354 2783-3500 4.88 µM -0.1891750016655 0.411247362825255 no 1999 0.424977829837356 2765 6740761
SGTC_351 caspofungin 25 nM -0.190571850563824 0.410627579004518 no 2000 0.424430522983383 2776 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1149 3909-7961 23.3 µM -0.19073648204504 0.410554546451688 no 2001 0.424366027416625 2750 735261
SGTC_2684 capsaicin 100 µM -0.190992820547142 0.410440837709546 no 2002 0.424265608997136 2833 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_217 ketoconazole 989 nM -0.191019184337914 0.410429143469066 no 2003 0.424255281485909 2820 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_627 1391-0720 175 µM -0.194697986555681 0.408798115090293 no 2004 0.42281469412236 2842 997839
SGTC_321 4534-3890 65.3 µM -0.195433447784285 0.408472230460659 no 2005 0.422526816936148 2874 699746
SGTC_1722 st034304 3.6505 µM -0.19602029275651 0.408212243431477 no 2006 0.422297141392718 2785 4036148 YLR033W RSC58
SGTC_869 0564-0080 44.1 µM -0.196332916927548 0.408073759576099 no 2007 0.422174799372073 2787 6843321
SGTC_215 1287-0124 461.5 µM -0.196530662894268 0.407986169513124 no 2008 0.42209741754569 2825 5560863
SGTC_2151 5563267 85.4165 µM -0.197201907473676 0.407688881183122 no 2009 0.42183476898904 2797 5310824
SGTC_1037 k284-1091 78.7 µM -0.197729736622682 0.407455147607292 no 2010 0.421628261282788 2733 3334711
SGTC_1665 st014639 11.4 µM -0.198527746944535 0.40710183484415 no 2011 0.421316088921854 2792 981133 YIL048W NEO1
SGTC_402 epigallocatechin gallate 10 µM -0.200071717215824 0.406418469020745 no 2012 0.420712246268767 2774 65064 An antioxidant.
SGTC_1194 1488-0194 225 µM -0.201325304663774 0.405863836978142 no 2013 0.420222108684458 2741 1391452
SGTC_1985 st071382 65.5 µM -0.203953415747384 0.404701680762179 no 2014 0.419194951260293 2774 6123237
SGTC_373 0844-0104 25.9 µM -0.204982182859797 0.404246986030828 no 2015 0.418793022736983 2880 5375804
SGTC_363 0455-0021 3.06 µM -0.205279258098405 0.404115708682829 no 2016 0.418676974308327 2763 4597466
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.205443171720821 0.404043279984735 no 2017 0.41861294669504 2790 688669
SGTC_1165 k072-0275 30.3 µM -0.205938508157604 0.4038244251118 no 2018 0.418419472470294 2804 6153523 YGL055W OLE1
SGTC_2913 7966556 36.57 µM -0.206548938491313 0.403554759632769 no 2019 0.418181070693355 2797 2976516
SGTC_2162 5663267 200 µM -0.206679347639106 0.403497155647358 no 2020 0.418130143676646 2877 6456493
SGTC_2027 5150920 200 µM -0.20715200681101 0.4032883914357 no 2021 0.417945573644201 2854 786715
SGTC_177 1327-0068 8.361 µM -0.207927714465587 0.402945836453494 no 2022 0.417642704525311 2766 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2587 piperic acid 92.2 µM -0.209005500193322 0.402470006511589 no 2023 0.417221972454089 2864 5370536
SGTC_2069 5228469 200 µM -0.209314428583723 0.402333644804831 no 2024 0.41710139443299 2903 2835210
SGTC_3099 9120367 49.47 µM -0.209837802475033 0.402102653487138 no 2025 0.416897133861955 2761 24824940
SGTC_1990 st072050 59.8 µM -0.209981519117311 0.40203923005756 no 2026 0.416841048545912 2736 17233948
SGTC_1264 0783-0040 158 µM -0.210503144861472 0.401809053670257 no 2027 0.416637498703162 2741 2855798
SGTC_2765 myclobutanil 7.74 µM -0.210643244377942 0.401747238132519 no 2028 0.416582832594435 2881 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2225 6654152 15.4 µM -0.211776255061287 0.401247414907247 no 2029 0.416140797036463 2797 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2126 5251174 33.877 µM -0.212256255758544 0.401035713153107 no 2030 0.415953560340951 2917 790722
SGTC_1905 st060207 84.5 µM -0.212343516959797 0.400997230183873 no 2031 0.415919523898766 2749 1948547
SGTC_3353 9151644 39.2805 µM -0.212402341284286 0.400971288673332 no 2032 0.415896579684861 2894 4909158
SGTC_2155 5570423 76 µM -0.212864466109068 0.400767506953497 no 2033 0.415716339555433 2804 797402
SGTC_1550 gossypolone 36.6 µM -0.213106381061157 0.400660841247104 no 2034 0.415621993798817 2788 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2137 5261020 140 µM -0.215562834612106 0.399578156774846 no 2035 0.41466426417561 2772 763655
SGTC_1406 3909-7906 11.9 µM -0.218026687588063 0.398492986156927 no 2036 0.413704158943201 2816 X1406
SGTC_733 4069-0007 56.1 µM -0.219252510444234 0.397953380792898 no 2037 0.41322667650202 2805 5717425 YNL287W SEC21
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.220960182641459 0.39720199155048 no 2038 0.412561718167915 2960 688751
SGTC_1622 st003707 19.4 µM -0.222817599846502 0.396385146378207 no 2039 0.411838734818264 2923 10140899
SGTC_3074 9116018 49.47 µM -0.223117200625497 0.396253432007858 no 2040 0.411722145800267 2766 17027303
SGTC_253 dyclonine 31.25 µM -0.225375795486259 0.395260861429024 no 2041 0.41084346984788 2806 3180 An oral anasthetic.
SGTC_1160 4092-0570 10.5 µM -0.225566126924109 0.395177248599402 no 2042 0.410769444331452 2806 4994975
SGTC_7 0192-1582 4.227 µM -0.22761814604083 0.394276101389761 no 2043 0.409971555862403 2844 252616
SGTC_1871 st057448 67.3 µM -0.22765297394135 0.394260811533998 no 2044 0.40995801690454 2992 691747
SGTC_2657 nystatin 74.44 µM -0.228024725994127 0.394097618190071 no 2045 0.409813509131638 2857 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1741 st038134 10.228 µM -0.22937691335468 0.393504186059504 no 2046 0.409287989162725 3033 1272587
SGTC_3062 9077494 49.47 µM -0.22946976223271 0.393463446690639 no 2047 0.409251909940553 2930 16459633
SGTC_1831 st055328 12 µM -0.22969432493277 0.393364919976059 no 2048 0.409164652532529 2974 1103068
SGTC_2043 5101342 149 µM -0.231676747308492 0.392495430559596 no 2049 0.40839454650653 2842 678451
SGTC_1054 3429-0080 167 µM -0.23193902496505 0.392380435796311 no 2050 0.40829268667001 2990 1162877
SGTC_1728 st035614 33.7865 µM -0.232104505563952 0.392307886213876 no 2051 0.408228422748551 2921 15945546
SGTC_2664 lyso-paf C-16 73.48 µM -0.234177087384799 0.391399547960717 no 2052 0.407423751065101 2824 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3269 9137823 49.47 µM -0.234799668254646 0.391126808480129 no 2053 0.40718211261935 2809 17682936
SGTC_969 1313-0238 134 µM -0.236354962606546 0.390445701170056 no 2054 0.406578620406975 2832 5212874
SGTC_404 fumagillin 50 µM -0.237224058182131 0.390065245909174 no 2055 0.406241486600433 2869 12015870 A methionine aminopeptidase binder.
SGTC_3138 9097216 49.47 µM -0.238078211964045 0.389691434143396 no 2056 0.405910216632118 2760 25237486
SGTC_3319 9138450 16.7555 µM -0.238897622359121 0.389332923340911 no 2057 0.405592484635875 2857 2029690
SGTC_2105 5350118 200 µM -0.240303461895851 0.38871805591425 no 2058 0.405047505714449 2875 2133313
SGTC_2720 fluspirilene 36.88 µM -0.240773628615078 0.38851248274749 no 2059 0.404865284863932 2926 3396 An atypical antipsychotic.
SGTC_115 0527-0192 112.043 µM -0.240804527867531 0.388498973617378 no 2060 0.404853310072001 2909 4233931
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.242772417701866 0.387638892123649 no 2061 0.404090851954091 2842 390807
SGTC_566 0958-0068 16.5 µM -0.243281739237906 0.387416378801748 no 2062 0.40389357474453 3009 6815365
SGTC_87 0100-0052 35.5 µM -0.24418214662862 0.38702309769358 no 2063 0.403544876777936 2881 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2893 9048488 25.97 µM -0.244716886895451 0.38678958800111 no 2064 0.40333782584436 2881 6467338
SGTC_1347 1493-0251 600 nM -0.244974689884282 0.38667702555786 no 2065 0.403238014443069 2965 3986378
SGTC_1983 st071813 46.9 µM -0.245099174261784 0.386622676358804 no 2066 0.403189821136513 2893 11838595
SGTC_2244 6635614 200 µM -0.245884244819252 0.386279970117606 no 2067 0.402885920149177 2788 836499
SGTC_2628 lathosterol 100 µM -0.246652929976291 0.385944502518844 no 2068 0.402588418787484 2992 6710616
SGTC_2082 5219693 150 µM -0.247087256474371 0.385754992551095 no 2069 0.402420347942148 2827 2834649
SGTC_1424 4048-1941 275 µM -0.247734548371724 0.385472609858557 no 2070 0.402169899589816 2966 X1424
SGTC_2092 5303694 80.6725 µM -0.248260236021039 0.385243321978657 no 2071 0.401966531555099 2856 1963699
SGTC_2223 6903751 107.57 µM -0.248306180901515 0.38522328421884 no 2072 0.401948758534365 2941 5598863
SGTC_2418 pentamidine 31.67 µM -0.24875193506831 0.385028895125388 no 2073 0.401776336403853 2842 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_823 0417-1665 178 µM -0.248818731072381 0.384999768519994 no 2074 0.401750500693552 2948 3429856
SGTC_1056 3448-1962 115 µM -0.249292315770601 0.384793279057201 no 2075 0.401567337430177 2941 715507
SGTC_2512 diallyl trisulfide 49.23 µM -0.249876966815846 0.384538408206139 no 2076 0.401341248058217 2845 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_964 1287-0107 19.4 µM -0.24997656474982 0.384494994782291 no 2077 0.401302736007675 2997 51516812 YPR165W RHO1
SGTC_3268 9137683 49.47 µM -0.251403384405184 0.383873222215333 no 2078 0.400751125671183 2826 1953228
SGTC_2031 5180455 200 µM -0.251810267975841 0.383695967149265 no 2079 0.400593860158555 2848 29949
SGTC_1897 st060201 15 µM -0.25215390399103 0.383546284248462 no 2080 0.400461053154349 2873 611878
SGTC_604 1000-0114 314 µM -0.252990072422011 0.383182133948328 no 2081 0.400137942386107 3011 1572745
SGTC_1023 4482-3888 16 µM -0.253017312250573 0.38317027277123 no 2082 0.400127417566707 3046 3303168
SGTC_2933 9026794 32.47 µM -0.253384322869586 0.383010474153839 no 2083 0.399985620501552 2910 17586027
SGTC_1560 lithocholic acid 53.1 µM -0.254634170230343 0.382466432630486 no 2084 0.39950283243648 2875 9903 A bile acid which acts as a detergent.
SGTC_2481 5478948 45.16 µM -0.254804618197456 0.382392256898585 no 2085 0.399437004089371 2998 77792
SGTC_172 1112-0046 2.638 µM -0.254835463912153 0.382378833887917 no 2086 0.399425091536907 2892 2802135 YIL048W NEO1
SGTC_1204 4049-0315 18.3 µM -0.254956046378182 0.382326361837688 no 2087 0.399378523731677 3099 588402
SGTC_1940 st075990 51.1 µM -0.255392037577039 0.382136656170914 no 2088 0.399210160014806 3107 1084979
SGTC_319 1348-1596 45.5 µM -0.255762965261184 0.381975282790932 no 2089 0.399066936184421 3056 5380505
SGTC_554 4483-2211 187 µM -0.255970218798623 0.381885125345168 no 2090 0.398986916675137 2960 747107
SGTC_694 1315-0438 43.2 µM -0.256006638810047 0.381869282922762 no 2091 0.398972855537208 2895 6793154
SGTC_2475 5812728 15.03 µM -0.25623424513163 0.381770280421204 no 2092 0.398884983634652 2821 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_230 MPP+ 141.667 µM -0.256942031341672 0.381462462288747 no 2093 0.398611761595229 2895 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_339 3091-4833 71.4 µM -0.258228522614464 0.38090315583696 no 2094 0.39811527317373 2865 3240077
SGTC_1393 3470-5649 58.2 µM -0.260976500411461 0.379709297649907 no 2095 0.397055314695369 2945 4108395
SGTC_2269 7935389 174.42 µM -0.261510428319746 0.379477465400188 no 2096 0.396849454307853 2844 97605
SGTC_2582 agaric acid 100 µM -0.262772788171112 0.378929519420681 no 2097 0.396362855276481 2981 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_3333 9141820 12.094 µM -0.263257301636273 0.378719273710303 no 2098 0.396176133772437 2900 1939433
SGTC_3239 9133757 49.47 µM -0.264551651136996 0.378157790685619 no 2099 0.395677435051672 2851 17036923
SGTC_2470 5664817 21.68 µM -0.264735582773063 0.378078022811089 no 2100 0.395606582038868 2849 2859561
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.265895292449551 0.37757519719829 no 2101 0.395159925357951 3031 5377381
SGTC_44 0929-0055 61.211 µM -0.267020050501672 0.37708772398581 no 2102 0.394726861671435 2864 1379590
SGTC_1638 st008370 60.6 µM -0.269156130547048 0.376162480724606 no 2103 0.393904768815579 2842 24207134
SGTC_2288 7946289 167.31 µM -0.27045359386041 0.375600831250712 no 2104 0.393405656870364 3080 1246052
SGTC_229 benomyl 22.8748 µM -0.271010583809875 0.375359800690257 no 2105 0.393191446040019 2967 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_3115 9123671 49.47 µM -0.27260614257965 0.374669611810377 no 2106 0.39257799481685 2881 3286988
SGTC_3028 9087778 49.47 µM -0.272839158621023 0.374568849880375 no 2107 0.392488428444502 2875 17217395
SGTC_2821 7996764 71.43 µM -0.274877474280258 0.37368779734215 no 2108 0.391705186843525 3116 2987135
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.276039835107641 0.373185667289551 no 2109 0.391258735200809 2997 7104
SGTC_176 1486-1328 72.834 µM -0.276191639841048 0.373120104805613 no 2110 0.391200439021161 2964 22310231
SGTC_252 miconazole 1.30953 nM -0.279177051651992 0.371831493190065 no 2111 0.390054476947078 3006 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2152 5568786 200 µM -0.279307054534701 0.371775411739605 no 2112 0.390004596452859 2902 5399883
SGTC_3256 9138902 49.47 µM -0.27936104354548 0.371752122424562 no 2113 0.389983882071038 2899 17228773
SGTC_1865 st057639 52.2 µM -0.280198439568124 0.371390953875204 no 2114 0.389662631892523 2860 688818
SGTC_278 4092-0821 23.9 µM -0.280275590323002 0.371357684478154 no 2115 0.389633038342363 2965 877900
SGTC_285 1486-1325 46 µM -0.280327206097634 0.371335426960334 no 2116 0.389613239878234 3023 22310230
SGTC_579 4491-1009 110 µM -0.28075122886528 0.371152598097498 no 2117 0.389450606657681 3010 1271041
SGTC_1340 1486-1359 257 µM -0.28201346859988 0.370608521609855 no 2118 0.388966591423567 2909 4309068
SGTC_1184 1269-1718 139 µM -0.282483902130014 0.370405811800275 no 2119 0.388786244207274 3055 5403821
SGTC_1345 1488-0192 31.4 µM -0.282778754404999 0.370278778293371 no 2120 0.3886732207145 3057 658348
SGTC_1116 jasmonic acid 1.58368 µM -0.284188217385818 0.369671724026446 no 2121 0.388133072273004 3065 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_3243 9134147 49.47 µM -0.284307469271786 0.369620377238035 no 2122 0.388087381288952 2962 24282180
SGTC_1518 st038567 90.8 µM -0.28431851604711 0.369615620898956 no 2123 0.388083148830208 2913 77966
SGTC_605 1315-0399 119 µM -0.284331280325504 0.36961012509046 no 2124 0.388078258344321 3039 24020461
SGTC_1860 st056228 74.6 µM -0.285145257409172 0.369259712849683 no 2125 0.387766429109584 3015 688679
SGTC_2011 4012611 177 µM -0.285195388148813 0.369238135414963 no 2126 0.387747226718713 2896 2049887
SGTC_999 SEC7.066 22.7 µM -0.286819539051861 0.368539286383477 no 2127 0.387125250618281 2914 740511 YDR170C SEC7
SGTC_2176 5809774 33.9695 µM -0.28711140350661 0.368413747260371 no 2128 0.38701351043647 3044 2870539
SGTC_1775 st081588 35.1725 µM -0.28945823760805 0.367404819385132 no 2129 0.386115367079819 2917 1426443 YGL099W LSG1
SGTC_2479 5617353 43.85 µM -0.290274163623245 0.367054258404465 no 2130 0.385803251390725 3076 2731746
SGTC_2987 9018338 71.43 µM -0.290525365732486 0.366946352217755 no 2131 0.385707174070726 2963 5055682
SGTC_2407 paclitaxel 400 µM -0.291067391469142 0.36671355587464 no 2132 0.385499889274761 3143 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1564 D-Arginine 115 µM -0.293113041158397 0.365835405578811 no 2133 0.384717874468225 2957 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2396 5342950 42.78 µM -0.296570754764239 0.364352687989994 no 2134 0.383397120577865 3020 1886677
SGTC_3051 9093778 49.47 µM -0.296874749896083 0.364222427131006 no 2135 0.383281067116936 2964 17217378
SGTC_1849 st056239 19.2 µM -0.296877960007323 0.364221051693132 no 2136 0.383279841677783 2914 5393181
SGTC_3318 9139014 38.6185 µM -0.29726166885376 0.364056656384991 no 2137 0.383133371729465 2914 16643984
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.298555294329807 0.363502603032069 no 2138 0.382639690179543 2929 6708514
SGTC_1483 3453-0561 55.9 µM -0.298755580732151 0.363416846847218 no 2139 0.382563272637018 3015 4546991
SGTC_2859 9028643 45.46 µM -0.298808065557227 0.363394375667651 no 2140 0.382543248262461 2998 17151580
SGTC_1767 st044992 70.3 µM -0.298828336702075 0.363385696779404 no 2141 0.382535514358719 2979 9600693
SGTC_730 1436-0052 41.2 µM -0.299394377679301 0.363143380320515 no 2142 0.382319575754804 2927 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2037 5169046 200 µM -0.30045072522468 0.362691315084577 no 2143 0.381916688329554 3038 5718022
SGTC_890 0929-0006 47.2 µM -0.300662769259681 0.362600593615648 no 2144 0.381835830837219 2937 1378169
SGTC_84 0443-0269 128.823 µM -0.301470240477004 0.362255193692922 no 2145 0.381527969852678 2977 6150058
SGTC_491 tetrandrine 80.3 µM -0.30301666469401 0.361594016035261 no 2146 0.380938580849804 3033 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_3121 9125696 49.47 µM -0.303101083557434 0.361557934404522 no 2147 0.380906414206195 2956 1235365
SGTC_1105 epirubicin 18.1 µM -0.305914109990086 0.360356319071328 no 2148 0.379835021222757 2920 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_107 0358-0022 2.6945 µM -0.306029077736282 0.360307238558622 no 2149 0.379791253186755 3020 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1253 0550-0034 176 µM -0.307981705947809 0.359474000461849 no 2150 0.379048126369796 3068 5969915
SGTC_1318 1280-3875 124 µM -0.307998023723226 0.359467040043512 no 2151 0.379041918066618 3010 373245
SGTC_1503 4585-0012 61.3 µM -0.308641749959826 0.359192493030669 no 2152 0.378797029222005 3128 2922052
SGTC_3254 9136651 49.47 µM -0.30867595230222 0.359177907882601 no 2153 0.378784019193854 2983 16454030
SGTC_1731 st035964 63 µM -0.308811613740989 0.359120058832251 no 2154 0.378732417088892 2962 6739575
SGTC_2067 5224629 34.075 µM -0.310140553473592 0.35855354040393 no 2155 0.378227037207507 3093 2835000
SGTC_1479 0549-0158 134 µM -0.310617887440101 0.358350131893836 no 2156 0.37804556360302 2994 5440202
SGTC_1700 st030840 7.9285 µM -0.311286313878654 0.35806535982503 no 2157 0.3777914853769 3059 5499307
SGTC_1413 3910-0535 34.4 µM -0.312138494350634 0.357702416884108 no 2158 0.377467636345735 3065 2876951
SGTC_3013 9080133 71.4286 µM -0.312153464386816 0.357696042307066 no 2159 0.377461948141911 3175 17050193
SGTC_2964 9083345 53.42 µM -0.312239148767089 0.357659556740679 no 2160 0.377429390935213 3015 17741579
SGTC_1163 k060-0048 49.9 µM -0.313531619576946 0.357109363164558 no 2161 0.376938400918971 2960 6809982
SGTC_2289 7946404 165.07 µM -0.315072550754962 0.356453790354991 no 2162 0.376353284607213 2936 1246120 YPR165W RHO1
SGTC_390 dec-rvkr-cmk 16.7 µM -0.315974973622606 0.356070060823361 no 2163 0.376010751938819 3010 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2504 purpurogallin 52.29 µM -0.317176945784181 0.35555918289392 no 2164 0.375554671042385 2929 5281571 An antioxidant.
SGTC_1250 0485-0349 40.2 µM -0.317410011019946 0.355460152454425 no 2165 0.375466255985204 2982 6842794 YDL195W SEC31
SGTC_1759 st043059 70 µM -0.319384573286226 0.354621544420871 no 2166 0.374717453743843 2951 669426
SGTC_303 1348-1668 34.2 µM -0.320503134834476 0.354146796994667 no 2167 0.374293477174793 3002 5380509
SGTC_1127 asiatic acid 681.4 nM -0.321238517009354 0.353834804552999 no 2168 0.374014822655331 2956 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1522 st012842 45.6 µM -0.321243908653744 0.353832517461947 no 2169 0.374012779870626 2884 3491067 YOR116C RPO31
SGTC_1376 2910-0861 41.3 µM -0.325165166404733 0.352170554027451 no 2170 0.372528035281381 2961 1112859
SGTC_200 k038-0079 37.545 µM -0.325648422316206 0.35196592812261 no 2171 0.372345185853089 2973 3436683
SGTC_3130 9127414 49.47 µM -0.325733714110288 0.351929817316095 no 2172 0.372312917002729 3020 1494646
SGTC_1676 st018489 23.4 µM -0.326343097047633 0.351671855879902 no 2173 0.372082392352518 2991 3696235
SGTC_1519 esterone 74 µM -0.327829974964272 0.351042723699501 no 2174 0.371520110958233 2962 698 A steroid.
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.328055526159337 0.350947323416233 no 2175 0.371434839874392 3070 1377
SGTC_452 diindolylmethane 8 µM -0.329422896861217 0.350369174646816 no 2176 0.370918031766073 3093 3071 Inhibits expression of several cancer promoting factors.
SGTC_3280 9140961 49.47 µM -0.331455510975959 0.349510389770877 no 2177 0.37015022026281 2962 4901226
SGTC_929 2805-0021 398 µM -0.33490749121756 0.348053684268572 no 2178 0.368847435474084 3069 3098024
SGTC_673 1082-0474 110 µM -0.335150386156994 0.347951268808363 no 2179 0.368755822924034 3028 3098046
SGTC_2916 7875993 68.79 µM -0.33571110200423 0.347714888085199 no 2180 0.36854436652435 3079 1299250
SGTC_1259 0671-0132 43 µM -0.337257125092108 0.347063438655929 no 2181 0.367961538731235 3019 X1259
SGTC_3263 9137018 49.47 µM -0.337408692203632 0.346999596939919 no 2182 0.367904416508681 3048 43844957
SGTC_2100 5377183 190 µM -0.337493682773582 0.346963799887583 no 2183 0.367872386759811 3071 2844202
SGTC_706 4262-0057 46.9 µM -0.338603980384054 0.34649628084877 no 2184 0.36745404182675 3004 883298
SGTC_2815 7968870 71.43 µM -0.339064745835571 0.346302332424773 no 2185 0.367280477857945 2987 2977326 YHR190W ERG9
SGTC_920 mycophenolic acid 780.421 nM -0.339414023912354 0.346155338847635 no 2186 0.367148927705184 3029 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2451 5856223 45.7 µM -0.33980926390837 0.345989030160762 no 2187 0.367000085518936 3031 2179896
SGTC_992 3909-8734 162 µM -0.34038126036171 0.345748398677142 no 2188 0.36678471457718 3040 4288319
SGTC_329 k048-0121 21.3 µM -0.342451087226969 0.344878170600042 no 2189 0.366005723921891 3072 6832902
SGTC_2570 licareol 100 µM -0.34253516922728 0.344842836867993 no 2190 0.365974090848108 3073 443158
SGTC_577 r071-0003 38.6 µM -0.344694750918151 0.343935781534595 no 2191 0.365161932366663 3010 4568517 YMR134W ERG29
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.344713815644386 0.343927778064443 no 2192 0.365154765340704 3068 75037 A free radical scavenger.
SGTC_736 0958-0254 92.6 µM -0.34526380236901 0.343696920928625 no 2193 0.364948028443379 3117 6812352
SGTC_1414 3917-0015 5.4 µM -0.345375216601575 0.343650161858111 no 2194 0.364906153243441 3116 6618702
SGTC_1970 st070122 35.8 µM -0.346896512830583 0.343011933668017 no 2195 0.364334533265609 3187 102928
SGTC_3007 9078383 71.4286 µM -0.346910177432546 0.343006202994315 no 2196 0.364329400219881 3028 6496995
SGTC_3340 9146634 11.102 µM -0.347418896967688 0.342792881422717 no 2197 0.36413831935734 3115 4907387
SGTC_420 mitomycin C 81.9 mM -0.347475779175125 0.342769032097124 no 2198 0.36411695584932 3012 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2166 5933061 31.504 µM -0.349674617778981 0.341847593658839 no 2199 0.363291452312394 3470 2877375
SGTC_638 3970-0837 4.09 µM -0.350132982085622 0.341655631330806 no 2200 0.363119449741839 3034 4118451 YLR208W SEC13
SGTC_293 4049-0273 38.5 µM -0.350322232033894 0.341576385657606 no 2201 0.36304844118447 3058 1380311
SGTC_1732 st034308 51.822 µM -0.3511637846156 0.341224082313676 no 2202 0.362732738907073 2915 830119
SGTC_2867 9039098 71.43 µM -0.351182044995496 0.341216439412494 no 2203 0.362725889692818 2985 6463460
SGTC_527 4476-4215 268 µM -0.352180254661826 0.34079873688898 no 2204 0.362351542026167 3036 4418754
SGTC_1523 st012844 44.7 µM -0.352191034305244 0.340794227192967 no 2205 0.362347500171795 3143 4274103
SGTC_1419 3993-2473 62.6 µM -0.352324136382799 0.340738545416478 no 2206 0.362297594478158 3072 704026
SGTC_3179 9107801 49.47 µM -0.35289270978401 0.340500728130166 no 2207 0.362084438215622 3022 4818259
SGTC_1320 1313-0481 95.3 µM -0.357929501493536 0.338396766542268 no 2208 0.360198036179668 3205 6813365 YLR208W SEC13
SGTC_1900 st060200 72.8 µM -0.358103449878888 0.338324194647264 no 2209 0.360132948701273 3015 688945
SGTC_1162 k048-0130 20.1 µM -0.358136457471024 0.338310424438353 no 2210 0.360120598478318 3027 6797406
SGTC_3321 9137793 26.8275 µM -0.358774316382212 0.338044362981024 no 2211 0.359881963896302 3108 4904192
SGTC_2968 9090663 33.37 µM -0.358861795106977 0.338007880467726 no 2212 0.359849240775501 3075 25236811
SGTC_1954 st077032 68.9 µM -0.358999734825145 0.337950356570161 no 2213 0.359797643824379 3111 698907
SGTC_1430 4049-0248 69.1 µM -0.359376905824433 0.337793087286945 no 2214 0.359656574419772 3147 22774488
SGTC_123 0083-0120 66.675 µM -0.359456190665002 0.337760031426512 no 2215 0.359626922754631 3056 16001701
SGTC_1921 5740136 50 µM -0.36000251181726 0.3375322903175 no 2216 0.359422627587321 3207 1774243
SGTC_2382 9035899 200 µM -0.361389965829248 0.336954179547322 no 2217 0.358903973994438 3052 6462679
SGTC_78 0336-0123 156.75 µM -0.367490032162744 0.334417045592803 no 2218 0.356626762851602 2945 6765896
SGTC_97 0535-0701 19.132 µM -0.367692323112692 0.334333037551729 no 2219 0.356551332718703 3073 2832013 YGL099W LSG1
SGTC_1296 1068-0102 11.9 µM -0.367878021441131 0.334255927451677 no 2220 0.356482094571839 3138 767053
SGTC_610 4215-0184 155 µM -0.369015104712851 0.33378391318393 no 2221 0.356058233087286 3115 5605015
SGTC_3181 9108277 49.47 µM -0.369573379500367 0.333552264096687 no 2222 0.355850194489479 3057 17097298
SGTC_3320 9137005 35.139 µM -0.370849922614495 0.333022817141299 no 2223 0.355374657777415 3103 4908713
SGTC_2361 9034121 116 µM -0.370961943731896 0.332976372184097 no 2224 0.355332938501988 3082 6496917
SGTC_2521 angolensin 13.4 µM -0.371984820697836 0.332552396832709 no 2225 0.354952075519972 3207 821428 A flavenoid.
SGTC_2601 securinine 100 µM -0.373180635530231 0.332057011427643 no 2226 0.354507003740674 3043 442872 A GABA receptor antagonist.
SGTC_729 4092-0585 94.1 µM -0.374069856709651 0.331688827479987 no 2227 0.354176172126808 3044 2169061
SGTC_889 0919-1524 82.7 µM -0.375188154892372 0.331226024457865 no 2228 0.353760269440812 3125 3905452
SGTC_2084 5306078 60.6385 µM -0.375315589893192 0.331173302357946 no 2229 0.353712886563776 3076 679340
SGTC_2911 7942208 15.64 µM -0.376855121998894 0.330536635563386 no 2230 0.353140637051635 3151 1243384
SGTC_2238 6671620 73.2395 µM -0.377231471422733 0.330381072375735 no 2231 0.353000797085673 2993 729941
SGTC_3329 9141233 27.5565 µM -0.378091356154883 0.330025750969883 no 2232 0.352681364671078 3203 4909101 YNL103W MET4
SGTC_1364 1653-0028 37.6 µM -0.37907276752975 0.329620399654206 no 2233 0.352316914091656 3121 5718652
SGTC_2139 5578692 56.4705 µM -0.37975823730413 0.32933739942982 no 2234 0.352062442859339 3149 650991 YMR113W FOL3
SGTC_38 0929-0051 58.268 µM -0.379846118235599 0.329301124336331 no 2235 0.352029823059332 3189 1379719
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.379912925341018 0.329273549076449 no 2236 0.352005026207954 3065 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1623 st003709 20.3 µM -0.381716896244796 0.328529294683055 no 2237 0.351335683013699 3057 16192618
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.382350198883936 0.328268177538781 no 2238 0.351100812337742 3084 6708784 An antioxidant flavonoid
SGTC_850 0388-0143 75.9 µM -0.382452487131622 0.328226010914582 no 2239 0.351062882394537 3075 67273
SGTC_858 0438-0351 2.77 µM -0.382473648604151 0.328217287723653 no 2240 0.351055035603505 3106 2799119
SGTC_2445 5742597 35.57 µM -0.383516998557995 0.327787313820379 no 2241 0.350668234489322 3061 1774255
SGTC_731 3966-0296 387 µM -0.383801548501994 0.327670087812122 no 2242 0.350562770133842 3063 660956
SGTC_3185 9108267 49.47 µM -0.384345357521788 0.327446102123052 no 2243 0.350361247164573 3163 4910486
SGTC_3129 9127257 49.47 µM -0.384475286181111 0.327392595905565 no 2244 0.350313104858061 3070 837894
SGTC_3279 9140807 49.47 µM -0.38456778981117 0.327354503935529 no 2245 0.35027883106719 3113 45595718
SGTC_1948 st076329 66.6 µM -0.385175642820147 0.327104241533086 no 2246 0.350053644009154 3029 24208413
SGTC_1438 4092-1045 4 µM -0.386503651416272 0.326557750541527 no 2247 0.34956184943819 3083 1351342
SGTC_3276 9139060 49.47 µM -0.387371539013709 0.326200805605489 no 2248 0.349240585411197 3044 4870619
SGTC_2178 5812956 200 µM -0.388282975814672 0.325826121070667 no 2249 0.348903317129047 3049 5403383
SGTC_1527 coumarin 137 µM -0.389105253860048 0.325488239868497 no 2250 0.348599143563434 3261 323 A hepatotoxic, DNA x-linker.
SGTC_2873 9040596 71.43 µM -0.389191030030577 0.32545300194666 no 2251 0.348567419212207 3203 6463863
SGTC_2654 protoveratrine a 100 µM -0.390338429806064 0.324981785920441 no 2252 0.348143154855211 3096 5702278 A heart drug and vasodilator.
SGTC_3211 9128781 49.47 µM -0.390371119910515 0.324968364791158 no 2253 0.34813107009155 3157 17194361
SGTC_1147 3809-1045 12.3 µM -0.390408524449048 0.324953008399768 no 2254 0.348117242701542 3106 325925
SGTC_2381 9035592 200 µM -0.39144077101316 0.324529338160551 no 2255 0.347735730350441 3132 4749657
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.391738007551293 0.324407383913841 no 2256 0.347625902012213 3153 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1957 st077035 62.4 µM -0.393834818110084 0.323547611564323 no 2257 0.346851498232731 3211 705593
SGTC_2474 5321570 43.32 µM -0.39388159254077 0.323528442977506 no 2258 0.346834230561738 3184 2841384
SGTC_490 phenamil 164 µM -0.393975221303096 0.323490074466627 no 2259 0.346799666678574 3150 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1786 berberine 21.6 µM -0.394437097406341 0.323300827851946 no 2260 0.346629179705154 3122 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2380 9035439 200 µM -0.395654187239594 0.3228023630866 no 2261 0.346180078263342 3244 6462575
SGTC_2971 9092186 9.93 µM -0.396817587861801 0.322326184393329 no 2262 0.345750990040148 3046 25236400
SGTC_1966 st070145 16.1 µM -0.398610477353228 0.321592927281331 no 2263 0.345090120160593 3037 3748532
SGTC_2927 9011802 47.9 µM -0.399377228537486 0.321279552725802 no 2264 0.344807635077392 3194 43912568
SGTC_344 k064-0035 6.43 µM -0.40075126448315 0.32071829654962 no 2265 0.344301631705127 3093 5088750
SGTC_824 1304-0008 100 µM -0.400869720312794 0.32066992973602 no 2266 0.344258022114862 3123 768245
SGTC_118 0083-0097 135.343 µM -0.400946973537082 0.32063838803791 no 2267 0.344229582405984 3144 5207356
SGTC_608 k048-0125 159 µM -0.401306119124233 0.32049176959106 no 2268 0.344097379481251 3225 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.401721168821875 0.320322363606389 no 2269 0.343944621763211 3234 5282362
SGTC_2524 avocatin b 10.57 µM -0.402278818840433 0.320094813060094 no 2270 0.343739420551741 3176 6710748
SGTC_3077 9117319 49.47 µM -0.402847222360928 0.319862944141387 no 2271 0.343530309689508 3145 17154678
SGTC_2942 9052777 62.25 µM -0.406346343616264 0.318437099893995 no 2272 0.342244069181166 3140 6469503
SGTC_1705 st027868 56.3335 µM -0.406518722098863 0.318366927239974 no 2273 0.342180751772902 3179 292948
SGTC_1874 staurosporine 7.6 µM -0.40661312434177 0.318328500286528 no 2274 0.342146078180408 3226 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_795 0685-0265 78 µM -0.406707471308936 0.318290097786378 no 2275 0.342111426220246 3136 302754
SGTC_2700 st077718 96.8 µM -0.407517888510272 0.31796031023679 no 2276 0.341813829210403 3163 904970
SGTC_1075 aripiprazole 15.2 µM -0.40790028142859 0.317804751068217 no 2277 0.341673443069571 3107 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1575 cyproterone acetate 48 µM -0.408744505312666 0.317461430848655 no 2278 0.341363584620128 3149 9880 An androgen receptor antagonist and liver toxin.
SGTC_2735 sertaconazole 140 nM -0.40986659276849 0.317005354932627 no 2279 0.340951906436554 3187 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1719 st032227 49.2 µM -0.410524025131576 0.316738268564257 no 2280 0.340710791618137 3114 3125804
SGTC_2755 lomerizine 42.69 µM -0.410625071477125 0.316697226263047 no 2281 0.340673738407124 3151 3949 A calcium channel blocker.
SGTC_1896 st058441 89 µM -0.410875308469304 0.316595596457207 no 2282 0.340581984319024 3152 688759
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.411536131019134 0.316327280375309 no 2283 0.34033972669394 3198 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_15 0266-0086 27.098 µM -0.411567518144026 0.316314538555373 no 2284 0.340328221808246 3229 1712902 YIL048W NEO1
SGTC_2135 5326629 150.42 µM -0.411748942177822 0.316240892490776 no 2285 0.340261724116535 3140 5020077
SGTC_834 0312-0008 75.7 µM -0.412130754883249 0.316085925796488 no 2286 0.340121793818033 3145 6385573 YIL048W NEO1
SGTC_1278 0874-0585 172 µM -0.41246991186171 0.315948298915814 no 2287 0.339997514854605 3190 766306
SGTC_61 0978-8327 98.565 µM -0.413356953587374 0.315588465916167 no 2288 0.339672554005534 3247 6150059 YHR072W ERG7
SGTC_458 nppb 133 µM -0.414175209844243 0.315256691040465 no 2289 0.339372897805238 3311 4549 A chloride channel blocker.
SGTC_3351 9150312 21.596 µM -0.416292374966913 0.31439894484471 no 2290 0.33859803574434 3215 4904905
SGTC_2343 7990716 14.84 µM -0.416827539957213 0.314182286945661 no 2291 0.338402278478862 3092 6456862
SGTC_1026 k007-1105 30.6 µM -0.417547061020438 0.313891094644009 no 2292 0.338139154683076 3162 7066794
SGTC_3192 9110362 49.47 µM -0.417723485189905 0.313819712942257 no 2293 0.338074649666035 3211 16649480
SGTC_1696 st025591 34.7925 µM -0.41968515627435 0.313026485423524 no 2294 0.337357735110893 3142 2787147
SGTC_26 0302-0163 425.158 µM -0.421720547277164 0.312204362160479 no 2295 0.336614502475612 3185 3100915
SGTC_3193 9111931 49.47 µM -0.421975176557794 0.31210157945266 no 2296 0.336521568217497 3118 17087244
SGTC_549 1661-1316 519 µM -0.422146515695458 0.312032425565122 no 2297 0.336459038705296 3289 2857282
SGTC_2998 9066762 71.4286 µM -0.422915392655984 0.311722182075569 no 2298 0.336178495932695 3334 4945196
SGTC_170 4197-0004 226 µM -0.422994845239223 0.311690130400583 no 2299 0.336149510993507 3250 218692
SGTC_2477 5967686 25.23 µM -0.42417121697592 0.311215741621344 no 2300 0.335720475217888 3095 776118
SGTC_1403 3909-7815 62.9 µM -0.425970491929013 0.310490764591472 no 2301 0.33506467394884 3128 6615483
SGTC_3106 9121286 49.47 µM -0.429266724639279 0.309164531698066 no 2302 0.33386456484421 3341 15943471
SGTC_723 4182-0001 115 µM -0.429334697209474 0.309137209137702 no 2303 0.333839834866981 3167 744821 YLR208W SEC13
SGTC_288 1315-0019 35.1 µM -0.430686485893805 0.308594057487815 no 2304 0.333348173207412 3276 6811474
SGTC_316 k060-0003 58.6 µM -0.431575420663877 0.308237109574525 no 2305 0.333025012951383 3260 6152314
SGTC_106 0092-0003 11.579 µM -0.431815549579997 0.308140717927542 no 2306 0.332937738575786 3199 1072148
SGTC_19 0279-0214 38.434 µM -0.431816818926146 0.308140208426532 no 2307 0.332937277258501 3184 3566274 YBR002C RER2
SGTC_773 4358-1457 44.6 µM -0.432331149367792 0.307933792509867 no 2308 0.332750375441645 3286 1186886
SGTC_40 0327-0103 19.753 µM -0.433435723509182 0.307490699861764 no 2309 0.332349126298903 3145 409036
SGTC_3026 9090633 49.47 µM -0.434322313675326 0.307135253119347 no 2310 0.332027201244091 3147 25236842
SGTC_1998 st075797 76.8 µM -0.434454736433098 0.307082178473032 no 2311 0.331979128551895 3285 24208315
SGTC_1388 3346-4487 254 µM -0.434978610165573 0.30687225107486 no 2312 0.331788976723242 3247 3345614
SGTC_1609 st001574 46.4 µM -0.436234512664394 0.306369242036304 no 2313 0.331333294999731 3165 3960012
SGTC_2249 haloperidol 116.36 µM -0.436345600334555 0.306324767189128 no 2314 0.331293000834686 3196 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_668 1682-0499 62.6 µM -0.436928183583234 0.30609157200658 no 2315 0.331081715892564 3233 682214
SGTC_1647 st011722 22.4 µM -0.438092530435473 0.305625745187406 no 2316 0.330659604462357 3294 2854783
SGTC_3004 9076122 71.4286 µM -0.438325313880972 0.305532651890098 no 2317 0.330575239132108 3301 44782551
SGTC_2263 7948595 193.29 µM -0.440222848969574 0.304774270859807 no 2318 0.329887856232268 3158 2971371
SGTC_3182 9108849 49.47 µM -0.440394950539799 0.304705529049538 no 2319 0.329825540723651 3275 17133045
SGTC_3112 9123419 49.47 µM -0.442330148367047 0.303933036183674 no 2320 0.329125158844689 3240 17015854
SGTC_1463 k081-0032 34.1 µM -0.442676284741311 0.303794957480225 no 2321 0.328999949166549 3239 977755
SGTC_2677 mitomycin C 100 µM -0.442836090952329 0.303731217963565 no 2322 0.328942148122131 3216 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2540 epiandrosterone 100 µM -0.443118610080834 0.303618548382491 no 2323 0.328839972485788 3228 441302 A steroid.
SGTC_2593 nobiletin 86.24 µM -0.443512954267518 0.303461313798998 no 2324 0.328697375678499 3215 72344 An anti-infammatory.
SGTC_523 1934-0222 13.7 µM -0.44371664092975 0.303380113239672 no 2325 0.328623731340364 3183 1361595
SGTC_3169 9102970 49.47 µM -0.444957166615475 0.302885782148525 no 2326 0.32817535439158 3282 17027839
SGTC_1359 1582-0056 520 nM -0.445189615613885 0.30279319479732 no 2327 0.328091365282004 3279 3661189
SGTC_2714 st079313 56.9 µM -0.445474525391098 0.302679728951613 no 2328 0.327988432754938 3191 2939799
SGTC_830 4076-0286 57.8 µM -0.445661782268256 0.302605163930064 no 2329 0.3279207874923 3192 6866659
SGTC_2881 9058953 51.95 µM -0.445761903159016 0.302565299525593 no 2330 0.327884621823015 3151 17122249
SGTC_1155 4088-0394 48.2 µM -0.447650710813126 0.301813688285504 no 2331 0.327202649466818 3174 2326248
SGTC_1648 st011736 69.8 µM -0.447671362862928 0.301805474876743 no 2332 0.327195196025532 3325 2855514
SGTC_2413 inermin 26.06 µM -0.447972512063579 0.301685717963862 no 2333 0.327086517410047 3407 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1317 1273-0028 910 nM -0.448564089758529 0.301450529642546 no 2334 0.326873071757053 3197 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_10 0279-0212 42.575 µM -0.448882578750559 0.301323944967021 no 2335 0.326758181996977 3229 39851 YBR002C RER2
SGTC_2221 6807166 181.081 µM -0.452028119825586 0.300075025315908 no 2336 0.325624362469701 3245 674925
SGTC_1252 0493-0875 34.8 µM -0.453112754225252 0.29964492079247 no 2337 0.32523377588287 3161 3960963
SGTC_3274 9138298 49.47 µM -0.454393035207397 0.299137593656923 no 2338 0.324772982191837 3219 17015756
SGTC_1827 berberine 7.24 µM -0.454565379298116 0.299069329968723 no 2339 0.324710973237664 3170 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2154 5570129 200 µM -0.455124659313289 0.298847853747213 no 2340 0.324509779214871 3295 673366
SGTC_154 3389-1638 511.116 µM -0.456189315599461 0.298426453414308 no 2341 0.324126923928913 3248 5238686
SGTC_3079 9117512 49.47 µM -0.456792104116426 0.29818798436551 no 2342 0.323910240813681 3274 7185044
SGTC_2907 7721985 69.9 µM -0.456921330397819 0.298136872481143 no 2343 0.323863795878409 3265 3267881
SGTC_1962 st076595 64.5 µM -0.457142161254742 0.298049538177253 no 2344 0.32378443389049 3213 279619
SGTC_2304 7443016 91.4 µM -0.457968273553692 0.297722930277988 no 2345 0.323487617487695 3227 939854
SGTC_2235 salicylic acid 500 µM -0.458319628533465 0.297584069723936 no 2346 0.323361412108497 3285 338 A COX inhibitor and kinase inhibitor.
SGTC_1232 0279-0259 161 µM -0.459798333291876 0.296999988571156 no 2347 0.322830489830583 3233 1560000
SGTC_728 3030-5151 22.5 µM -0.460796964922733 0.296605830853294 no 2348 0.322472139729711 3214 3125388
SGTC_838 0109-0203 71.4 µM -0.461056077221706 0.296503598961498 no 2349 0.322379186506521 3233 759422
SGTC_1785 bathophenanthroline 24 µM -0.461298420763748 0.296407997742285 no 2350 0.322292258909669 3198 72812 An iron chelator.
SGTC_2776 terbinafine 19.92 µM -0.463156078277702 0.295675646949825 no 2351 0.321626248093752 3284 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3087 9117406 49.47 µM -0.463194121100361 0.29566065788861 no 2352 0.321612614889346 3303 42546093
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.463296203663441 0.295620438577396 no 2353 0.321576033290359 3229 689007
SGTC_1038 k292-0204 154 µM -0.464647666525334 0.295088215555932 no 2354 0.321091895617193 3168 4454212
SGTC_3234 9132280 49.47 µM -0.465175449351592 0.294880487949041 no 2355 0.320902909234252 3287 17612295
SGTC_1999 st074831 12.5 µM -0.465614792271689 0.294707620416253 no 2356 0.320745626443737 3214 17112523
SGTC_1745 st081495 74 µM -0.465770614061117 0.294646320703511 no 2357 0.320689850670826 3301 13842402 YBL026W LSM2
SGTC_1029 k015-0030 64.7 µM -0.465800566723701 0.294634538111364 no 2358 0.320679129701431 3311 2208316
SGTC_3290 9121031 71.43 µM -0.465863057047813 0.29460995675604 no 2359 0.320656762994427 3251 17014854
SGTC_572 0960-0087 17.7 µM -0.468500888373354 0.293573196639928 no 2360 0.319713217923788 3251 6796365
SGTC_1909 st060837 51.5 µM -0.469543513190359 0.293163874901557 no 2361 0.31934059492027 3230 678937
SGTC_2996 9066192 71.4286 µM -0.469611709821863 0.293137110962183 no 2362 0.319316228521777 3251 6472854
SGTC_2673 kobusone 100 µM -0.4699035972037 0.29302257183128 no 2363 0.319211947082946 3295 6710676 An epoxy ketone and protein crosslinker.
SGTC_879 0831-1030 162 µM -0.469960821688891 0.293000118883308 no 2364 0.319191504396336 3281 1549252
SGTC_2055 5235184 200 µM -0.474001868238997 0.291416571734921 no 2365 0.317749287489419 3345 2836034
SGTC_2332 7982454 138.89 µM -0.474566592374387 0.291195594133651 no 2366 0.317547961376246 3319 2981748
SGTC_3141 9094609 49.47 µM -0.474795552414874 0.29110602394036 no 2367 0.317466351695013 3144 25236309 YDL196W YDL196W
SGTC_2778 tioconazole 65.09 nM -0.475869699788116 0.290685984561601 no 2368 0.317083605014583 3286 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_199 4063-0024 41.6 µM -0.47783635968797 0.289917668621501 no 2369 0.316383340013228 3337 306215
SGTC_2666 tannic acid 100 µM -0.47811508999616 0.289808854019546 no 2370 0.316284146190195 3352 16134267 A thiamine antagonist.
SGTC_261 5-fluorouridine 15.376 µM -0.479206450445123 0.289382978086914 no 2371 0.315895882905869 3412 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_883 0850-0245 24.6 µM -0.479748336070809 0.289171630164201 no 2372 0.315703176632789 3398 6823229 YPR165W RHO1
SGTC_419 nsc-638432 893 µM -0.480980097990254 0.288691484703303 no 2373 0.315265321807695 3281 368090
SGTC_785 1270-0111 65.3 µM -0.48174354793464 0.288394077617369 no 2374 0.314994068145045 3234 6741994
SGTC_1888 azatryptophan 97.5 µM -0.482096052499454 0.288256805839829 no 2375 0.314868856973047 3315 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1698 5-fluorocytosine 1.055 µM -0.482651910305689 0.288040407192891 no 2376 0.314671457068133 3351 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_654 1124-0271 80.9 µM -0.482736622923224 0.288007434817078 no 2377 0.314641378011189 3253 5403748
SGTC_1068 loratadine 26.9 µM -0.482943285502635 0.287927003788888 no 2378 0.314568003129417 3278 3957 A H1 histamine antagonist.
SGTC_1930 st074634 34.3 µM -0.483098433638239 0.287866628642389 no 2379 0.314512923096872 3220 684253 YOR116C RPO31
SGTC_2335 9018011 154.17 µM -0.483343709432101 0.287771192953065 no 2380 0.31442585474799 3300 6458208
SGTC_2931 9014674 55.67 µM -0.484108755801752 0.287473612971784 no 2381 0.31415434382788 3194 2996810
SGTC_2945 9067681 61.76 µM -0.484342267330129 0.287382813020389 no 2382 0.314071491839778 3365 16456930
SGTC_3204 9114183 49.47 µM -0.48568711910992 0.286860137446666 no 2383 0.313594508831637 3191 17027248
SGTC_3113 9123498 49.47 µM -0.485876977391649 0.286786385479088 no 2384 0.313527196242801 3346 8897275
SGTC_1737 st035557 69.7 µM -0.486070383601049 0.286711264533287 no 2385 0.313458632151617 3269 5716916
SGTC_1367 1812-0510 76.9 µM -0.486713029724601 0.286461721244735 no 2386 0.313230855117926 3297 1142582 YDR527W RBA50
SGTC_642 0335-0876 158 µM -0.488585032546962 0.285735399456826 no 2387 0.312567755832051 3298 6812350
SGTC_2883 9059145 45.46 µM -0.489479579696923 0.285388632072603 no 2388 0.312251104029428 3205 16476510
SGTC_2979 9012552 45.46 µM -0.49000019296197 0.285186910867704 no 2389 0.312066881145062 3376 17100905
SGTC_3258 9138477 49.47 µM -0.490738576102997 0.284900927293869 no 2390 0.31180567935932 3317 4970355
SGTC_347 4534-1311 26.2 µM -0.493277626762751 0.283918571607665 no 2391 0.310908217330799 3321 2862016
SGTC_2830 7992007 71.43 µM -0.493499997393872 0.283832613937533 no 2392 0.310829670838769 3240 1952075
SGTC_2544 sphondin 68.51 µM -0.493553129427248 0.28381207752185 no 2393 0.310810904641314 3413 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_799 1310-0557 151 µM -0.495032494818687 0.283240564005681 no 2394 0.3102885915546 3390 5354492
SGTC_1302 1159-0335 255 µM -0.496633983820445 0.282622494228762 no 2395 0.309723591861953 3279 649284
SGTC_2985 9022375 71.43 µM -0.496640547187644 0.28261996253364 no 2396 0.309721277252562 3437 4939335
SGTC_1545 lovastatin 49.4 µM -0.497171226052961 0.28241529924934 no 2397 0.309534155255891 3339 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2070 5230947 200 µM -0.498222570438108 0.282010045093492 no 2398 0.309163587864283 3406 2835538
SGTC_470 aa-861 153 µM -0.498478649819383 0.281911378450879 no 2399 0.309073356933741 3302 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_594 1487-1584 10.8 µM -0.498712602943561 0.281821251531163 no 2400 0.308990932374873 3263 5013332
SGTC_565 1418-0001 44.5 µM -0.49929565171917 0.28159670120978 no 2401 0.308785558983725 3414 2862145
SGTC_2552 juarezic acid 87.02 µM -0.500909768346348 0.280975504893774 no 2402 0.308217313718195 3329 1549512
SGTC_2988 9073640 71.4286 µM -0.500915793295125 0.28097318742016 no 2403 0.308215193511381 3442 9102229
SGTC_714 4296-0578 26.1 µM -0.500991053964555 0.280944239468527 no 2404 0.308188709479514 3291 1589775
SGTC_1812 st052057 4.327 µM -0.501023909181436 0.280931602626223 no 2405 0.308177148128109 3290 3645418
SGTC_1281 0884-0031 11.8 µM -0.50312050235215 0.280125775217322 no 2406 0.307439776443131 3315 1548255
SGTC_3067 9117431 49.47 µM -0.503665490614829 0.279916492079984 no 2407 0.307248231310351 3287 17150885
SGTC_2726 cimetidine 79.27 µM -0.504203763485089 0.279709862202731 no 2408 0.307059098015736 3315 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2817 7995342 71.43 µM -0.50570633171372 0.279133454764712 no 2409 0.30653141134965 3213 18879975
SGTC_1981 st071826 47 µM -0.506111310022999 0.278978197940312 no 2410 0.306389255625945 3336 11838600
SGTC_2743 auranofin 4.32 µM -0.506421440403307 0.278859331441288 no 2411 0.306280413174921 3284 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1304 1165-0502 251 µM -0.506431613078717 0.278855432884699 no 2412 0.306276843292009 3281 767425
SGTC_1323 1348-1351 11.2 µM -0.506890611332142 0.27867955487672 no 2413 0.306115786809928 3295 6989654
SGTC_1027 k015-0025 8.67 µM -0.507198061759733 0.278561776865953 no 2414 0.306007927429311 3330 3598955
SGTC_653 0203-0016 55.2 µM -0.508171825307659 0.278188907915473 no 2415 0.305666423922857 3332 295302
SGTC_3175 9106517 49.47 µM -0.508709838068462 0.27798299904322 no 2416 0.305477812733484 3365 41468073
SGTC_302 1094-0063 18.9 µM -0.509583521173938 0.277648780556843 no 2417 0.305171635538507 3271 5440289
SGTC_548 1436-0017 110 µM -0.510049310611816 0.277470677856122 no 2418 0.305008458007873 3443 9677137
SGTC_18 0111-0177 500 nM -0.511000106211953 0.277107298031287 no 2419 0.30467549120034 3394 721752
SGTC_1649 st011737 51.3 µM -0.512075606414484 0.2766965388758 no 2420 0.304299048035588 3340 1761035
SGTC_393 acivicin 6.25 µM -0.512758082922762 0.276436039654983 no 2421 0.304060277247166 3250 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1470 k295-0292 231 µM -0.512993430162357 0.276346236221735 no 2422 0.303977958182185 3389 5045612
SGTC_2655 perillic acid 100 µM -0.515270633612644 0.275478044385145 no 2423 0.303181958451942 3310 5702197 An apoptosis inducer.
SGTC_2904 7225135 42.03 µM -0.516889553149586 0.274861642680779 no 2424 0.3026166303305 3430 4446116
SGTC_1214 0358-0031 63.7 µM -0.517115790926577 0.274775557081074 no 2425 0.302537665533895 3457 4301366
SGTC_680 0417-1641 114 µM -0.517743540670221 0.274536762038484 no 2426 0.302318607582092 3246 2835990
SGTC_276 colchicine 750 µM -0.517793961745274 0.274517586381738 no 2427 0.302301015859743 3442 2833 A microtubule depolymerizer.
SGTC_3222 9128301 49.47 µM -0.51782537403591 0.274505640296575 no 2428 0.302290056462559 3282 4911358
SGTC_1135 dihydrocapsaicin 536.708 nM -0.517961708618746 0.274453795266394 no 2429 0.302242492916034 3333 107982 A Capsaicinoid.
SGTC_1356 1502-0781 85.8 µM -0.519115930902498 0.274015063760012 no 2430 0.30183994979619 3296 567702
SGTC_2912 7964298 10.93 µM -0.519157988498502 0.273999083791526 no 2431 0.30182528646519 3392 2975850
SGTC_405 ebelactone b 50 µM -0.520072318811815 0.273651793856941 no 2432 0.301506585456414 3336 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_17 0960-0276 49.807 µM -0.521751990578898 0.273014372462401 no 2433 0.300921510294281 3353 6821114
SGTC_484 loperamide 105 µM -0.521776605015437 0.273005036964561 no 2434 0.300912940226879 3338 3955 An opioid-receptor agonist.
SGTC_703 3875-0075 71.8 µM -0.524706921900018 0.271894790202873 no 2435 0.299893472347415 3378 2850814
SGTC_3303 9125618 40.5795 µM -0.5255706828295 0.27156795517659 no 2436 0.29959326539088 3360 22695467
SGTC_3151 9099821 49.47 µM -0.526113583404548 0.271362629388987 no 2437 0.299404645716354 3383 17174189
SGTC_1917 st066507 28.5 µM -0.528119171484849 0.270604784445751 no 2438 0.298708312634531 3271 3156428
SGTC_307 1501-1223 22.3 µM -0.528193604756598 0.27057667894898 no 2439 0.29868248384032 3392 2830329
SGTC_2719 novobiocin 32.65 µM -0.528743764126195 0.270368987745767 no 2440 0.29849160671814 3438 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1712 st032288 53.4 µM -0.530148351877212 0.269839102125422 no 2441 0.298004538609617 3435 2883011
SGTC_2662 daunorubicin 22.37 µM -0.53079234603777 0.269596327048802 no 2442 0.297781342295307 3342 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2010 4012422 159 µM -0.531412401825088 0.269362679798517 no 2443 0.297566514652978 3337 952393
SGTC_2741 miltefosine 3.04 µM -0.531845974738363 0.269199362711521 no 2444 0.297416338847691 3317 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2865 9030313 51.95 µM -0.532310152648824 0.269024572490057 no 2445 0.297255600827819 3275 42562754
SGTC_1765 st044815 90.4 µM -0.532823079289766 0.268831491784294 no 2446 0.297078028022869 3382 645695
SGTC_273 hydroxyurea 18.1 mM -0.53332755912707 0.26864165861336 no 2447 0.296903426793485 3393 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2887 9044784 58.44 µM -0.534232985741687 0.268301120255251 no 2448 0.296590175105387 3395 6465546
SGTC_2645 abamectin 100 µM -0.534612958531162 0.268158274093606 no 2449 0.296458760513476 3397 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1377 2944-0135 198 µM -0.53756833075797 0.26704854589412 no 2450 0.295437549464604 3392 1894137
SGTC_304 1310-0298 97 µM -0.538495287782219 0.266700956303128 no 2451 0.295117578731704 3401 1550234
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.538954156978973 0.266528974570434 no 2452 0.294959243502 3393 442882
SGTC_826 1683-5028 118 µM -0.539064855393513 0.266487493793042 no 2453 0.294921052292932 3423 722377
SGTC_3075 9116269 49.47 µM -0.540509830145332 0.265946334262482 no 2454 0.294422741808711 3476 17015205 YNL244C SUI1
SGTC_2005 4024620 188 µM -0.541969082240632 0.265400393323389 no 2455 0.293919902501875 3432 236743
SGTC_2369 9071472 200 µM -0.542340446991186 0.265261547773938 no 2456 0.293791998460873 3432 17296037
SGTC_2675 theaflavin digallate 100 µM -0.542476209364353 0.265210798255433 no 2457 0.293745246127304 3418 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2000 st075254 36.4 µM -0.542510779554789 0.265197876312809 no 2458 0.293733341780232 3406 17234175
SGTC_1942 st076330 65.2 µM -0.544316918525549 0.264523207161287 no 2459 0.293111703272915 3494 24208414
SGTC_3233 9132340 49.47 µM -0.544942263219183 0.264289818218186 no 2460 0.292896613870425 3348 17682950
SGTC_1987 st072290 61.9 µM -0.545580360607029 0.264051777884488 no 2461 0.292677213678423 3354 54697379
SGTC_2698 st077697 67.5 µM -0.545723263606174 0.263998483321546 no 2462 0.292628089095079 3348 3154499
SGTC_624 k048-0052 28 µM -0.546313796085182 0.263778306969934 no 2463 0.292425127256148 3362 6835531
SGTC_1173 0443-0020 122 µM -0.547389654532953 0.263377420703181 no 2464 0.292055530631898 3368 5331295
SGTC_1661 st013063 9.66 µM -0.548285392368508 0.263043888429629 no 2465 0.291747977996919 3418 721395
SGTC_317 4495-0002 170 µM -0.548466273194983 0.262976562793344 no 2466 0.291685890673522 3414 15991618
SGTC_3349 9149703 23.001 µM -0.548479574852742 0.262971612132215 no 2467 0.291681325124094 3441 4910494
SGTC_1578 josamycin 24.2 µM -0.548662222147962 0.262903638592041 no 2468 0.291618638167633 3356 5282165 A P450 substrate.
SGTC_2204 7233102 200 µM -0.548872282597667 0.26282547415226 no 2469 0.291546550422321 3360 2172480
SGTC_1904 st060225 78 µM -0.549704659759637 0.262515859754979 no 2470 0.291260980134124 3439 66595
SGTC_2889 9059656 51.95 µM -0.550374470856049 0.262266849726985 no 2471 0.291031277536354 3437 3949838
SGTC_2029 5175081 200 µM -0.550813814625843 0.262103584329004 no 2472 0.290880656545446 3428 1380876
SGTC_209 4077-0173 175.592 µM -0.551763379874745 0.261750892564775 no 2473 0.290555239971021 3390 15993494
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.555312620167665 0.260434777119827 no 2474 0.289340424095413 3458 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2248 tofa 1.1 µM -0.555983548557007 0.260186369654611 no 2475 0.289111050644337 3359 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1857 st056007 79.3 µM -0.557638401427585 0.259574192162218 no 2476 0.288545664159623 3459 619834
SGTC_2189 6047310 154.431 µM -0.558106348136687 0.25940122024632 no 2477 0.288385883006298 3414 711535
SGTC_2541 muurolladie-3-one 83.07 µM -0.55836012240251 0.25930743998335 no 2478 0.288299248824462 3507 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1087 pterostilbene 9.05 µM -0.560002438194845 0.258700959060567 no 2479 0.287738887313511 3486 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1559 coumarin 343 70.1 µM -0.560724181110252 0.258434663394429 no 2480 0.287492790026072 3498 108770 A hepatotoxic, DNA x-linker.
SGTC_2683 piperine 63.03 µM -0.560940360426471 0.258354929100017 no 2481 0.287419097360386 3381 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2981 9013952 38.96 µM -0.561186000171514 0.258264344269583 no 2482 0.28733537287012 3401 2996344
SGTC_1389 3405-0187 19 µM -0.561190789132375 0.258262578402996 no 2483 0.287333740702911 3383 799890
SGTC_3240 9133527 49.47 µM -0.561330903757101 0.258210915740654 no 2484 0.287285988966398 3423 17617455
SGTC_2611 pyromycin 23.93 µM -0.561803384462981 0.258036743510268 no 2485 0.287124992962569 3373 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1294 1000-1494 117 µM -0.562200215204979 0.257890505486958 no 2486 0.286989807410027 3408 712797 YDL207W GLE1
SGTC_499 genistein 192 µM -0.56258750917578 0.257747823381236 no 2487 0.28685789976042 3461 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_379 3970-0972 5.9 µM -0.563058542253379 0.257574346378794 no 2488 0.286697510313445 3424 2898042 YBL034C STU1
SGTC_2810 7959871 45.46 µM -0.563422544608867 0.257440329320392 no 2489 0.286573594569928 3417 2974535
SGTC_3083 9117465 49.47 µM -0.564263206900318 0.257130955851343 no 2490 0.286287508681243 3439 16420915
SGTC_2826 7992541 19.48 µM -0.565330745840578 0.256738367959552 no 2491 0.285924409928049 3508 2985066
SGTC_9 0092-0002 10.449 µM -0.56598289170626 0.256498694673363 no 2492 0.285702705321721 3464 759368
SGTC_2325 6158266 200 µM -0.567526117228465 0.255932000995207 no 2493 0.28517839377355 3429 3623240
SGTC_2466 5983409 37.09 µM -0.567605918698786 0.255902714570807 no 2494 0.285151293663098 3400 2879657
SGTC_2939 9044578 71.43 µM -0.568530217173628 0.255563632791668 no 2495 0.28483749680683 3428 2653634
SGTC_2715 st079500 56.4 µM -0.569572055924709 0.255181712542128 no 2496 0.284483992984142 3423 28246688
SGTC_472 calcifediol 10 µM -0.570332862823489 0.254903002431151 no 2497 0.284225977879966 3445 5283731 A vitamin D metabolite.
SGTC_1883 5-benzylidenerhodanine 20 µM -0.570870967359132 0.254705972194089 no 2498 0.284043556181516 3455 1273210
SGTC_1959 st077091 55.8 µM -0.57157237710896 0.254449266537342 no 2499 0.283805856842954 3444 821356 YKL052C ASK1
SGTC_206 4546-0025 72.014 µM -0.573220002179638 0.253846793681103 no 2500 0.283247871401915 3484 6620745 YIL048W NEO1
SGTC_2205 7238770 200 µM -0.574368623362167 0.253427230669419 no 2501 0.282859190383351 3487 279867
SGTC_976 1348-1067 47.6 µM -0.578062073448245 0.252080578404205 no 2502 0.28161110581949 3496 5310671 YGL099W LSG1
SGTC_635 k038-0028 24.7 µM -0.57860036225949 0.251884630995497 no 2503 0.281429430124858 3445 4035102
SGTC_2295 7971645 200 µM -0.578689852372801 0.251852062680761 no 2504 0.281399232159802 3416 2978226 YKL099C UTP11
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.578712907844227 0.251843672417376 no 2505 0.281391452466341 3363 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2954 9074818 52.69 µM -0.579262902112241 0.2516435642549 no 2506 0.28120589663437 3495 16648742
SGTC_952 1185-0122 232 µM -0.579472127859519 0.25156746228252 no 2507 0.281135324038658 3465 678600
SGTC_147 4466-0538 29.23 µM -0.57948173389162 0.251563968559048 no 2508 0.281132084094951 3575 6742687 YHR072W ERG7
SGTC_1400 3771-8998 51.5 µM -0.579666100345048 0.251496919263346 no 2509 0.281069904065711 3443 670767
SGTC_768 0384-0033 77.3 µM -0.580496045891147 0.251195206573835 no 2510 0.280790076237838 3391 3965305 YMR134W ERG29
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.580859684223375 0.251063072333677 no 2511 0.280667512910707 3435 5379071
SGTC_2680 butyl paraben 22.24 µM -0.581287300012657 0.250907737843117 no 2512 0.280523419271005 3501 7184 An antifungal and steroid mimetic.
SGTC_2518 prenyletin 46.28 µM -0.581380131843205 0.250874022738879 no 2513 0.280492142471135 3433 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2924 9010168 62.78 µM -0.581511618143658 0.250826273025174 no 2514 0.280447845137754 3476 2993929
SGTC_2234 tolnaftate 200 µM -0.582259402451864 0.250554804034572 no 2515 0.28019598330455 3437 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2787 5284540 71.43 µM -0.582340503079215 0.250525371340854 no 2516 0.280168674325645 3435 736958
SGTC_1124 fisetin 1.16336 µM -0.585500642072665 0.249379935048785 no 2517 0.279105567501991 3441 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_3120 9124077 49.47 µM -0.585728297312166 0.24929752587258 no 2518 0.279029057483805 3505 18774327 YGL155W CDC43
SGTC_3123 9126162 49.47 µM -0.586255485368702 0.249106744075209 no 2519 0.278851920112745 3499 25239884
SGTC_2775 cyproheptadine 69.59 µM -0.587316731422921 0.248722930003467 no 2520 0.278495503079449 3549 2913 A selective serotonin reuptake inhibitor.
SGTC_1444 4112-3581 28 µM -0.587795887931647 0.248549739781061 no 2521 0.278334652229689 3520 2877249
SGTC_2447 5741742 33.78 µM -0.588088033413197 0.248444175881771 no 2522 0.278236602431676 3494 1776504
SGTC_3330 9141424 71.43 µM -0.588258088524331 0.248382739142217 no 2523 0.278179536330891 3500 27261020
SGTC_2712 st079126 47.7 µM -0.588332020071146 0.248356032013956 no 2524 0.278154728594563 3465 3152970
SGTC_1730 st033808 45.1 µM -0.588343426389298 0.248351911717039 no 2525 0.27815090129969 3412 1045166
SGTC_1868 st057644 42.7 µM -0.588869239658025 0.248162012094251 no 2526 0.277974496932793 3432 688665
SGTC_530 4358-1714 28 µM -0.58957818896307 0.247906094791275 no 2527 0.277736738972583 3497 1564641
SGTC_3325 9138760 55.175 µM -0.591152361425324 0.24733835226814 no 2528 0.27720916936569 3414 43844959
SGTC_1274 0865-0114 173 µM -0.591168934998043 0.247332378527401 no 2529 0.277203617492222 3465 870624
SGTC_3272 9137413 49.47 µM -0.591887002288646 0.247073634067434 no 2530 0.276963129041092 3472 17614870
SGTC_1025 k007-0731 70 µM -0.592069516983967 0.247007890802796 no 2531 0.276902019193308 3411 6256118
SGTC_2838 9002687 71.43 µM -0.59241130136304 0.24688480249355 no 2532 0.276787600189747 3453 6457060
SGTC_451 chloral hydrate 100 µM -0.593948909144195 0.246331463347548 no 2533 0.276273142568485 3539 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2796 7949634 45.45 µM -0.595986824660433 0.245599104045308 no 2534 0.275592014238149 3498 2971588
SGTC_1626 st003712 1.76 µM -0.596870969458494 0.245281735835759 no 2535 0.275296765382522 3512 24207035
SGTC_528 3492-0019 172 µM -0.597109820793661 0.245196036791003 no 2536 0.275217030749866 3522 2869262
SGTC_2842 9000675 19.48 µM -0.597339040666098 0.245113808624072 no 2537 0.275140522036113 3458 2989072
SGTC_2301 7769476 200 µM -0.597797281178508 0.24494946823144 no 2538 0.274987602513006 3481 977820
SGTC_3208 9114115 49.47 µM -0.598466350004962 0.24470962426134 no 2539 0.274764402663815 3461 650895
SGTC_966 1300-0360 30.2 µM -0.600578601007712 0.24395326701633 no 2540 0.274060347132921 3478 70588
SGTC_866 0495-0101 262 µM -0.601396369747858 0.243660778495352 no 2541 0.273788008013291 3418 635694
SGTC_99 0109-0120 622.8 µM -0.602299671648091 0.24333791784402 no 2542 0.273487339686483 3573 759414
SGTC_1570 verbenone 133 µM -0.604495123980214 0.242554177980985 no 2543 0.272757255021112 3558 29025 A natural terpanoid with antifungal properties.
SGTC_581 0958-0271 211 µM -0.606336885992042 0.24189775555968 no 2544 0.272145534743549 3485 4591145
SGTC_2723 salbutamol 83.58 µM -0.606403888625315 0.241873893332561 no 2545 0.272123293444802 3522 9884233 β2-adrenoceptor agonist
SGTC_1683 st010134 710 nM -0.60676431698537 0.24174555278027 no 2546 0.272003665969753 3514 3818134
SGTC_2543 pimpinellin 60.67 µM -0.607115899908845 0.241620397511145 no 2547 0.271886999530972 3442 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1244 0416-0015 52.5 µM -0.607180897901628 0.241597263604773 no 2548 0.271865433848718 3512 96201
SGTC_1915 st067105 30.6 µM -0.607686370791755 0.241417398136643 no 2549 0.271697752061897 3539 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_3022 9087993 49.47 µM -0.609452315868502 0.240789582627223 no 2550 0.271112335103661 3545 17173644
SGTC_942 3253-1115 227 µM -0.610339210370455 0.240474616002103 no 2551 0.270818563953778 3571 46497897
SGTC_1097 itavastatin 7.23 µM -0.611246873903898 0.240152506033101 no 2552 0.27051807796481 3539 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2822 7994718 71.43 µM -0.611437424783728 0.240084913566563 no 2553 0.270455016423316 3496 1018011
SGTC_69 0096-0274 206.684 µM -0.611654782877219 0.240007824672984 no 2554 0.270383092183455 3671 6741392
SGTC_259 usnic acid 108.925 µM -0.611754845857644 0.239972340564306 no 2555 0.270349984351526 3605 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_791 1348-1292 225 µM -0.613219417481945 0.239453304987536 no 2556 0.269865633647321 3549 5437054
SGTC_599 1935-0052 86.5 µM -0.614015858839928 0.239171308386283 no 2557 0.26960242379031 3505 9557311
SGTC_2705 st078069 42.8 µM -0.61513475008966 0.238775448469387 no 2558 0.269232867322745 3491 1530061
SGTC_2803 7707263 71.43 µM -0.615506332348007 0.23864406325692 no 2559 0.269110194351912 3484 2199229
SGTC_2656 pseudo-anisatin 100 µM -0.616387819763079 0.238332542498212 no 2560 0.268819295164695 3539 6708809 A neurotoxin.
SGTC_2141 5621638 7.665 µM -0.616634444188849 0.238245424447688 no 2561 0.268737935053919 3564 2856238
SGTC_2833 9001315 45.46 µM -0.616880931830711 0.238158372148296 no 2562 0.26865663242922 3449 2989378
SGTC_2424 5537928 59.2 µM -0.617039935739215 0.238102225820104 no 2563 0.268604192402867 3536 5382802
SGTC_2620 irigenin 100 µM -0.619128586091627 0.237365370374688 no 2564 0.267915826419106 3569 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_72 0744-0168 198.391 µM -0.619543856880536 0.237219016262544 no 2565 0.267779069697093 3487 677577
SGTC_2019 4016004 108 µM -0.620295476920235 0.236954248494175 no 2566 0.267531636116315 3502 45595336
SGTC_1574 spiramycin 23.7 µM -0.620931533324947 0.236730316450414 no 2567 0.267322336218522 3558 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2784 7567673 72.73 µM -0.621214077474398 0.236630880405644 no 2568 0.267229389113368 3575 3471247
SGTC_3033 9090887 49.47 µM -0.6214819523478 0.236536628157373 no 2569 0.2671412827492 3512 19325384
SGTC_1515 3460-0031 42.1 µM -0.621802506555032 0.236423867749468 no 2570 0.267035868973286 3517 2876596
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.622560914235366 0.236157202772034 no 2571 0.266786551397237 3606 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1337 1486-1011 40.3 µM -0.623717702044325 0.235750781967136 no 2572 0.266406497739709 3581 X1337
SGTC_3056 9094900 49.47 µM -0.62384167997095 0.235707246995177 no 2573 0.266365782011771 3486 25236784
SGTC_2106 5357045 167.29 µM -0.624071645915758 0.23562650596576 no 2574 0.266290266979547 3530 668842
SGTC_1137 ixabepilone 100 µM -0.624270026875896 0.235556866681075 no 2575 0.266225132368184 3578 154225 A novel microtubule stabilizer.
SGTC_1325 1431-0015 227 µM -0.625570706816257 0.235100559803453 no 2576 0.265798278754589 3486 1103340
SGTC_1870 st057514 26.5 µM -0.626162157009845 0.234893227778192 no 2577 0.265604293036368 3528 5393161
SGTC_1020 4335-0961 93.3 µM -0.628061845301165 0.234227978745852 no 2578 0.264981713282335 3480 669075
SGTC_2872 9044037 25.97 µM -0.628625531730732 0.23403078308071 no 2579 0.264797120599326 3540 6465195
SGTC_2066 5222451 176 µM -0.629512212429802 0.233720779790992 no 2580 0.264506888030488 3576 2281147
SGTC_2072 5231554 129 µM -0.630263493385381 0.233458293505373 no 2581 0.264261101895113 3637 789545
SGTC_753 1322-0200 289 µM -0.630682659953748 0.233311914099289 no 2582 0.26412401956556 3609 5403907
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.631861496124645 0.232900519550099 no 2583 0.263738692633313 3535 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1 0258-0098 57.368 µM -0.63246187022177 0.232691153780939 no 2584 0.263542558217906 3492 6790032 YDR047W HEM12
SGTC_124 0136-0217 7.121 µM -0.63363181214901 0.232283465877171 no 2585 0.263160567361285 3673 3976905
SGTC_1391 3442-0225 151 µM -0.635503676409768 0.231632007546344 no 2586 0.262549984865484 3533 5227075
SGTC_3088 9117578 49.47 µM -0.637085289230256 0.23108235899735 no 2587 0.262034645086475 3634 678341
SGTC_3348 9149464 3.537 µM -0.638721819473392 0.230514392410118 no 2588 0.261501957823974 3586 1951442
SGTC_1787 fluconazole 80 µM -0.638757252898099 0.23050210368584 no 2589 0.261490430468533 3522 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_835 0312-0010 67.2 µM -0.639606575096252 0.230207658456584 no 2590 0.261214203381405 3555 1626196
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.640814535559039 0.229789242215288 no 2591 0.260821593951049 3601 16623 A steroid.
SGTC_208 k072-0098 12.366 µM -0.644896811835756 0.228378369452021 no 2592 0.259497028963061 3595 5948901
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.645120952634732 0.22830104553285 no 2593 0.259424403349917 3650 688801
SGTC_805 3852-0218 479 µM -0.645234997026907 0.228261708235696 no 2594 0.259387454965073 3554 6615355
SGTC_471 1-acyl-paf 4 µM -0.645523606405292 0.228162175314617 no 2595 0.25929396273003 3542 16759367
SGTC_2951 9072950 58.06 µM -0.647750182801098 0.227395115183552 no 2596 0.258573270524953 3615 16488155
SGTC_2191 5911152 200 µM -0.648273226113715 0.227215136633211 no 2597 0.258404123864491 3557 2875902
SGTC_2565 isoliquiritigenin 100 µM -0.648505785950728 0.227135138875204 no 2598 0.258328934894456 3547 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2952 9073731 13.78 µM -0.649420523585517 0.226820634336165 no 2599 0.258033300911616 3573 16457353
SGTC_998 3996-0085 177 µM -0.649794988587636 0.226691956912857 no 2600 0.257912328236895 3609 715391
SGTC_1605 st000082 49.1 µM -0.649808719606317 0.226687239305503 no 2601 0.25790789292627 3594 1114022
SGTC_1608 st001473 40.5 µM -0.649827110012235 0.22668092094527 no 2602 0.257901952630549 3535 7292267
SGTC_375 3970-0961 9.27 µM -0.650148300529129 0.226570586097311 no 2603 0.257798216142656 3549 2898222
SGTC_1680 diphenhydramine 100 µM -0.650331175438532 0.226507778750667 no 2604 0.257739161806523 3567 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1982 st072467 71.9 µM -0.65088619581395 0.226317220363964 no 2605 0.257559976508655 3562 3163533
SGTC_1836 st055642 81 µM -0.650914552704946 0.226307486859116 no 2606 0.257550823378745 3550 8571
SGTC_546 peri-Naphthalide 147 µM -0.651062694304004 0.226256641089469 no 2607 0.25750300849631 3537 223824 A penicillin ester.
SGTC_984 1492-0255 2.91 µM -0.653042804406394 0.225577639513144 no 2608 0.256864341805078 3547 1585198
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.653678900931118 0.225359759975345 no 2609 0.256659349677674 3566 688662
SGTC_1237 0330-0133 46.1 µM -0.653892647386266 0.225286573033593 no 2610 0.256590485641525 3552 X1237 YHR072W ERG7
SGTC_3082 9117008 49.47 µM -0.654326345835231 0.225138115740443 no 2611 0.256450787869189 3581 41448529
SGTC_817 1391-0715 46 µM -0.654360083415363 0.225126569510605 no 2612 0.256439922383672 3542 1353946
SGTC_1838 st055369 84.5 µM -0.65442875933498 0.225103067143843 no 2613 0.2564178054386 3571 676036
SGTC_1231 0242-0792 125 µM -0.654660517743594 0.225023764727723 no 2614 0.256343175435662 3598 3707635
SGTC_286 k060-0067 22.9 µM -0.654695205007473 0.225011896903242 no 2615 0.256332006542699 3571 5985051
SGTC_1221 2958-7315 257 µM -0.655178925276508 0.224846434877654 no 2616 0.256176280712133 3603 4562705
SGTC_430 0958-0115 16.4 µM -0.655455039018128 0.22475201796266 no 2617 0.256087412529343 3557 6833180
SGTC_3019 9081971 49.47 µM -0.656027213197867 0.22455643495857 no 2618 0.255903307445608 3650 16451803
SGTC_178 4092-0806 87.505 µM -0.656113434912968 0.224526970660604 no 2619 0.255875570386504 3601 2169044
SGTC_1447 4239-0816 81.9 µM -0.657533275440896 0.224042088239706 no 2620 0.255419041124345 3555 1341554
SGTC_2246 7293507 91.5585 µM -0.659154920447233 0.22348901700711 no 2621 0.254898145711712 3621 887656
SGTC_3338 9144300 39.5675 µM -0.660027736560247 0.223191659918044 no 2622 0.254618015094572 3579 4901274
SGTC_1265 0819-1001 68.8 µM -0.660473864820841 0.223039756850969 no 2623 0.254474892381922 3624 3106768
SGTC_1820 st053765 18.6 µM -0.660566506008128 0.223008220659421 no 2624 0.254445177385785 3595 3690829
SGTC_2358 9037157 4 µM -0.661061668177016 0.222839704478132 no 2625 0.254286383165014 3604 2388925
SGTC_861 0443-0273 110 µM -0.661231509734902 0.222781919825413 no 2626 0.254231928416728 3606 6149169
SGTC_1768 st044301 37.178 µM -0.661910303370257 0.222551061303138 no 2627 0.254014354077693 3616 3931349
SGTC_2339 9000433 200 µM -0.66232528551516 0.222409992593299 no 2628 0.253881387610391 3570 2988954
SGTC_2463 5473429 200 µM -0.664375678026096 0.221713732751806 no 2629 0.253224947830551 3563 5399405
SGTC_707 0865-0008 204 µM -0.664473013819055 0.221680711045877 no 2630 0.253193807667756 3630 723043
SGTC_3355 9151058 44.0485 µM -0.66462010769239 0.221630813968769 no 2631 0.253146752467896 3629 17015728
SGTC_2068 5226020 147 µM -0.664632054366478 0.221626761708466 no 2632 0.253142930939395 3644 1810509
SGTC_1594 piperine 70.1 µM -0.665399874216271 0.221366409351839 no 2633 0.252897382687883 3619 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1314 1222-0010 41.1 µM -0.666117856679422 0.221123114167371 no 2634 0.252667885869638 3615 3526027
SGTC_2420 aureobasidin a 50 nM -0.666373218527638 0.22103661927584 no 2635 0.252586288138328 3679 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_641 4092-0595 30 µM -0.666480302676582 0.221000354030089 no 2636 0.252552074849972 3626 786260
SGTC_2966 9084041 48.03 µM -0.666521474261501 0.220986411718397 no 2637 0.252538921215823 3540 17741380
SGTC_3247 9135149 49.47 µM -0.666884284427407 0.220863571749282 no 2638 0.252423025030345 3591 8934436 YOR116C RPO31
SGTC_1873 rapamycin 2 nM -0.667099900535925 0.22079058714828 no 2639 0.252354161839769 3617 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_803 4488-1585 147 µM -0.667458091586726 0.220669372423168 no 2640 0.252239785145125 3590 747204
SGTC_2696 st077691 74.316 µM -0.667819805074853 0.22054700436917 no 2641 0.252124311420657 3607 757133
SGTC_2779 methotrexate 400 µM -0.66907991667631 0.220121011074065 no 2642 0.251722250190617 3684 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1280 0880-0253 10.1 µM -0.669369353912263 0.220023230622837 no 2643 0.251629947884096 3606 6836607
SGTC_580 1123-0028 41 µM -0.669470795653869 0.21998896650316 no 2644 0.251597602073579 3689 1677248 YPR107C YTH1
SGTC_2342 7990637 118.86 µM -0.669529468048153 0.219969150043606 no 2645 0.251578894740601 3660 2033102 YER133W GLC7
SGTC_957 1187-1561 14.1 µM -0.670408728102398 0.219672304793164 no 2646 0.251298636109549 3606 1538454
SGTC_1446 4239-0190 62 µM -0.670547188327967 0.219625580481836 no 2647 0.251254517828866 3642 1340085
SGTC_1042 0350-0096 82 µM -0.670701680222968 0.21957345291585 no 2648 0.251205296131201 3635 3122515
SGTC_233 rapamycin 362 pM -0.672054474489199 0.219117306249434 no 2649 0.25077450872012 3644 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1030 k029-0042 36.7 µM -0.672546325562289 0.218951594883852 no 2650 0.250617979371888 3633 6080581
SGTC_596 1155-0152 116 µM -0.673081466447145 0.21877138049729 no 2651 0.25044773204576 3635 280313
SGTC_24 0417-1663 219 µM -0.67336591130206 0.218675625419995 no 2652 0.250357264986306 3613 4329390
SGTC_3163 9099914 49.47 µM -0.67409417736066 0.218430573038127 no 2653 0.250125720547602 3646 16268368
SGTC_787 4152-0075 138 µM -0.674490759476595 0.218297194677842 no 2654 0.249999679274407 3641 9566539
SGTC_2079 5212404 121 µM -0.674490759476595 0.218297194677842 no 2655 0.249999679274407 3639 758462
SGTC_2196 6573537 42.6665 µM -0.674490759476595 0.218297194677842 no 2656 0.249999679274407 3672 2903087
SGTC_2071 5230951 39.92 µM -0.674966988398587 0.218137091551145 no 2657 0.249848369291096 3680 1799272
SGTC_481 bay k-8644 50 µM -0.675447437175885 0.217975638353236 no 2658 0.249695767830338 3589 2303 A calcium channel antagonist.
SGTC_908 3448-7491 47.7 µM -0.677024946234314 0.217446006493657 no 2659 0.249195063356879 3663 1203031
SGTC_1511 0906-3109 28.5 µM -0.677341332264705 0.217339872768443 no 2660 0.249094706134386 3688 2882180
SGTC_985 1493-0307 8.71 µM -0.678499000052379 0.21695178074995 no 2661 0.248727678812007 3631 3278274
SGTC_2081 5214970 32.255 µM -0.678755957587684 0.216865693663131 no 2662 0.248646251994124 3600 2063512
SGTC_1324 1418-0026 34.4 µM -0.678980313291683 0.216790545142074 no 2663 0.248575167924935 3670 1372513
SGTC_1119 parthenolide 318.541 nM -0.67909873429337 0.216750885794497 no 2664 0.248537652198567 3722 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_909 3448-9333 149 µM -0.679348520594287 0.216667245796752 no 2665 0.248458529890917 3606 3344074
SGTC_1766 st045414 44.774 µM -0.679542298983097 0.216602372696718 no 2666 0.248397157896513 3685 253960
SGTC_1361 1608-0041 5.61 µM -0.680197367641473 0.216383152122563 no 2667 0.248189749451356 3632 X1361
SGTC_2173 5763948 167 µM -0.681777476584246 0.215854892985053 no 2668 0.247689834217762 3652 2867177
SGTC_1671 st016596 74.5 µM -0.681934299295684 0.215802505102215 no 2669 0.24764024796263 3686 2829167
SGTC_1046 2001-0062 216 µM -0.683033480289987 0.215435521783958 no 2670 0.247292843416169 3594 739778
SGTC_3117 9124945 49.47 µM -0.683971543505818 0.215122617335903 no 2671 0.246996567566063 3570 17592065
SGTC_620 0109-0052 432 µM -0.685444914592979 0.214631686274151 no 2672 0.246531604929849 3651 493037
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.685585358635809 0.214584923973114 no 2673 0.246487308454845 3692 368090
SGTC_3196 9111891 49.47 µM -0.686329640685953 0.214337206416708 no 2674 0.246252630851503 3665 18891510
SGTC_1615 st002656 86.5 µM -0.687163465682695 0.214059884144321 no 2675 0.24598986204532 3664 1584458
SGTC_3273 9137859 49.47 µM -0.687855984457033 0.213829717807335 no 2676 0.245771738419303 3716 2377234
SGTC_2140 5586273 200 µM -0.688044281843468 0.213767160000314 no 2677 0.245712448083055 3645 854421
SGTC_927 2425-1185 123 µM -0.688615163509781 0.213577561852467 no 2678 0.245532738071492 3644 730375
SGTC_2085 5307070 144.047 µM -0.68999510325158 0.21311966857317 no 2679 0.24509863336963 3625 2840351
SGTC_3245 9134821 49.47 µM -0.691573819668529 0.212596519921266 no 2680 0.244602503747304 3637 17014901
SGTC_194 1486-1323 56.904 µM -0.692081670626966 0.212428389898789 no 2681 0.244443020854338 3646 5178754
SGTC_1910 st062352 60.4 µM -0.693148996040426 0.212075292597433 no 2682 0.244108026182501 3624 2245730
SGTC_2131 toluylene red 5.2905 µM -0.695568450865874 0.211276149810959 no 2683 0.243349564835959 3672 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1818 st052136 56.3 µM -0.698087191601406 0.210446090245273 no 2684 0.242561333853323 3576 674169
SGTC_702 1488-0190 94 µM -0.698167299953115 0.210419721713698 no 2685 0.242536286936083 3667 949357
SGTC_2626 ethyl orsellinate 100 µM -0.698187410456523 0.21041310242827 no 2686 0.242529999345807 3659 75653 A natural product.
SGTC_1776 st049249 45.9 µM -0.698409452445042 0.210340026391641 no 2687 0.242460583329909 3686 1822314
SGTC_1472 k841-0093 193 µM -0.699566647053056 0.209959424391451 no 2688 0.242098988907012 3742 X1472
SGTC_853 0419-0306 21 µM -0.699939377242373 0.209836919434475 no 2689 0.241982582319237 3661 762713
SGTC_1469 k284-2957 126 µM -0.70018172290726 0.20975729040883 no 2690 0.241906912139728 3688 23884841
SGTC_1835 st008666 49.2 µM -0.700516924739467 0.209647180339567 no 2691 0.241802269646795 3621 690455
SGTC_1279 0874-0590 65.2 µM -0.702202370816437 0.209094045457783 no 2692 0.241276483654734 3704 3523074
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.704025933043333 0.208496552147445 no 2693 0.240708311889801 3696 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1188 1403-0014 4.57 µM -0.706206913292687 0.207783273937982 no 2694 0.240029735884629 3722 9614867
SGTC_636 0kpi-0074 126 µM -0.707670490990459 0.207305427647367 no 2695 0.239574953307191 3700 616434
SGTC_2818 7996756 12.99 µM -0.707824979975952 0.207255026184593 no 2696 0.239526975870078 3695 2241621
SGTC_157 1348-1695 65.819 µM -0.708224656992397 0.207124666658677 no 2697 0.239402878232731 3693 5380510
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.709748503240712 0.206628090840532 no 2698 0.238930054208483 3688 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1668 st014914 51.6 µM -0.709776343584675 0.206619025070135 no 2699 0.238921420567553 3694 2839556
SGTC_3296 9122258 64.045 µM -0.709927754620231 0.206569724570917 no 2700 0.238874469087512 3710 4730474
SGTC_1342 1486-1464 234 µM -0.710131826063281 0.206503288497282 no 2701 0.238811195976149 3720 3253938
SGTC_2947 9072639 7.68 µM -0.710335604294335 0.206436960511765 no 2702 0.238748022925231 3692 16488146
SGTC_1664 st014217 9.02 µM -0.712377269498907 0.205773113862073 no 2703 0.238115593634235 3744 3982782
SGTC_2777 climbazole 1.536 µM -0.712559279151036 0.205713995055125 no 2704 0.23805925865379 3660 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2040 5100729 123 µM -0.71351507534515 0.205403707064351 no 2705 0.237763543951987 3713 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_844 0330-0132 15.3 µM -0.713781653866228 0.205317215081926 no 2706 0.237681102917065 3696 2828079
SGTC_2713 st079149 53.4 µM -0.714037948275617 0.205234080203855 no 2707 0.237601857095725 3732 3103253
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.716455688358153 0.204450816317126 no 2708 0.236855009699858 3707 91467 include heat shock
SGTC_637 1181-0519 7.26 µM -0.716693147731751 0.204373983792658 no 2709 0.236781727439333 3712 6252091 YGR060W ERG25
SGTC_251 melphalan 456.522 µM -0.717315954976445 0.204172549514315 no 2710 0.236589582348521 3764 460612 A DNA alkylator.
SGTC_3213 9129884 49.47 µM -0.718474497818527 0.20379815721233 no 2711 0.236232383371367 3662 17190742
SGTC_2760 etidronate 98.04 µM -0.718757235933528 0.203706850309538 no 2712 0.236145255383402 3709 3305 A chelator and antioxidant.
SGTC_775 4577-0580 57.3 µM -0.71879514085756 0.203694611220647 no 2713 0.236133576026833 3759 2006902
SGTC_2094 5332512 191.667 µM -0.718940238984943 0.203647764660445 no 2714 0.236088870982554 3736 755774
SGTC_1104 tacrolimus 29.8 µM -0.719403445683563 0.203498256171799 no 2715 0.235946187212848 3740 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1371 2421-0008 32.7 µM -0.720812158550581 0.203043970671534 no 2716 0.235512546860277 3700 2827552
SGTC_2486 5283202 22.39 µM -0.721264159113716 0.202898336737417 no 2717 0.235373501964085 3725 1377751
SGTC_2591 skatole 100 µM -0.721439955327802 0.202841712305366 no 2718 0.235319435585722 3729 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2710 st078562 53.7235 µM -0.724393728525994 0.201891706624478 no 2719 0.234412024489851 3693 17250908
SGTC_271 rotenone 740 µM -0.724524333612131 0.201849762421064 no 2720 0.234371946825393 3735 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_631 k072-0230 41.5 µM -0.724931373220713 0.201719073939395 no 2721 0.234247066393851 3735 5773147
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.725698411062773 0.201472938351585 no 2722 0.234011838043327 3733 688664
SGTC_2972 9093619 59.92 µM -0.726404308973174 0.201246581123894 no 2723 0.233795475207805 3743 25236256
SGTC_1764 st044502 93.5 µM -0.726551388011349 0.201199437126813 no 2724 0.233750408375464 3736 8407
SGTC_1847 st056231 15 µM -0.729756354488833 0.200173778014527 no 2725 0.232769563669292 3723 5393180
SGTC_2592 piperlongumine 83.33 µM -0.730233476827107 0.200021357642752 no 2726 0.232623741464198 3733 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1744 st037937 38.9 µM -0.730362557778419 0.199980133743098 no 2727 0.232584299370793 3762 1016152
SGTC_1341 1486-1360 280 µM -0.731589704953293 0.199588481439529 no 2728 0.232209516903775 3711 3976547
SGTC_1016 4226-1401 38 µM -0.732607266200357 0.199264070238312 no 2729 0.231898999031411 3721 2901613
SGTC_3098 9119039 49.47 µM -0.73523241443484 0.19842860792213 no 2730 0.231098980563714 3729 17161528
SGTC_2762 leflunomide 42.06 µM -0.737353264308581 0.197755186229815 no 2731 0.230453774348311 3717 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1579 chlormadinone acetate 49.4 µM -0.740487325379268 0.196762577207117 no 2732 0.229502174528429 3746 45114258 A steroidal progestin.
SGTC_3317 9138495 8.753 µM -0.740854499493084 0.196646484868233 no 2733 0.229390833154334 3718 17020139
SGTC_91 0417-1751 58.384 µM -0.741982504090536 0.196290094368684 no 2734 0.229048968041164 3834 6795624
SGTC_2450 5739737 12.93 µM -0.742563071739219 0.196106818066258 no 2735 0.22887312648435 3761 2262825
SGTC_3057 9095946 49.47 µM -0.742933634697619 0.195989891305507 no 2736 0.228760930493012 3758 24540043
SGTC_3085 9117376 49.47 µM -0.743556251231085 0.195793527272628 no 2737 0.228572489344224 3827 16480349
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.745475086602267 0.195189106471023 no 2738 0.227992283287153 3730 641818 YHR062C RPP1
SGTC_1484 3473-2379 286 µM -0.746657790708319 0.194817127774264 no 2739 0.227635077308461 3854 671917
SGTC_2496 diffractaic acid 79.83 µM -0.746870993680972 0.194750118045957 no 2740 0.227570718257743 3776 94870 An apoptosis inducer which activates caspases.
SGTC_3244 9134489 49.47 µM -0.746974937651357 0.194717453524284 no 2741 0.227539344665869 3735 16584271
SGTC_211 3455-0679 143.504 µM -0.747844052357945 0.194444463612724 no 2742 0.227277113588112 3758 748649
SGTC_644 1498-1197 63.3 µM -0.748369037008372 0.19427967826496 no 2743 0.227118796677818 3813 6741615
SGTC_2423 st077119 87.2 µM -0.749042557813209 0.194068394070908 no 2744 0.226915777558397 3700 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_819 1013-0258 27.7 µM -0.749579588045341 0.193900027464517 no 2745 0.226753974111047 3784 5753198
SGTC_855 0428-0020 25 µM -0.749591404572128 0.193896323816744 no 2746 0.22675041460642 3775 6812414
SGTC_2476 5806916 10.51 µM -0.75219397565966 0.193081652126325 no 2747 0.225967207987052 3685 2870194
SGTC_1316 1272-0050 65.9 µM -0.753622619870687 0.192635339556953 no 2748 0.225537928948551 3757 7340392
SGTC_2177 5811945 192 µM -0.753967179503743 0.192527792577445 no 2749 0.225434464789327 3784 5343475
SGTC_2095 5432005 200 µM -0.756419675265829 0.19176335890376 no 2750 0.224698807576961 3769 783734
SGTC_2630 antimycin a 100 µM -0.758004315340694 0.191270422376982 no 2751 0.224224199673068 3772 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_432 NS 1619 61.3 µM -0.758990393534493 0.190964073862813 no 2752 0.223929151693193 3829 4552 A K+/calcium channel activator.
SGTC_35 0133-0054 64.071 µM -0.759373605213411 0.190845101343941 no 2753 0.223814549111362 3762 99677
SGTC_639 0833-0042 114 µM -0.760990867237211 0.190343504686392 no 2754 0.2233312610896 3755 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_3198 9112019 49.47 µM -0.76105177273819 0.190324630573377 no 2755 0.223313072249209 3810 45595555
SGTC_578 3460-0051 92 µM -0.761238289796177 0.190266837624661 no 2756 0.223257375973266 3843 2876744
SGTC_207 4185-0010 4.486 µM -0.762092194211451 0.190002390101308 no 2757 0.223002490646459 3838 3761753
SGTC_1288 0973-0013 65.5 µM -0.763391817148228 0.189600340873262 no 2758 0.222614879279351 3831 4315430
SGTC_2808 7946468 45.46 µM -0.764489913374583 0.189261043879688 no 2759 0.222287672645495 3803 2970879
SGTC_2773 thioridazine 9.09 µM -0.765711765861267 0.188883947555604 no 2760 0.221923912317428 3798 5452 An antipsychotic.
SGTC_1049 3226-0134 66 µM -0.766049492468501 0.188779797822359 no 2761 0.221823427001202 3815 5702385
SGTC_583 1488-1091 88.9 µM -0.767338453134954 0.188382627423361 no 2762 0.22144015569795 3875 4303273
SGTC_2990 9074105 71.4286 µM -0.769002187866799 0.18787073967379 no 2763 0.220946005857678 3735 6502001
SGTC_1497 4476-2978 41.3 µM -0.769093341386371 0.187842718955807 no 2764 0.220918950383758 3805 1528379
SGTC_2674 ligustilide 100 µM -0.769649456730711 0.187671824239001 no 2765 0.220753929668461 3801 5319022 A signalling regulator.
SGTC_1166 k206-0078 225 µM -0.772477764249758 0.1868041701859 no 2766 0.219915755809517 3812 5404595
SGTC_1960 st011366 51.8 µM -0.773995444541142 0.186339609062839 no 2767 0.219466742590174 3786 3972846
SGTC_529 4076-0302 30.3 µM -0.77414818976394 0.186292893508454 no 2768 0.219421581350019 3758 5816522
SGTC_1362 1611-0397 101 µM -0.774631365647647 0.186145166926107 no 2769 0.219278758873684 3770 27816
SGTC_2087 5276107 200 µM -0.774735410200168 0.186113365764298 no 2770 0.219248011226165 3758 144405
SGTC_2426 5582046 32.21 µM -0.7751338479819 0.185991614612881 no 2771 0.21913028627523 3777 2251934
SGTC_1092 toremifene 6.32 µM -0.775156653163679 0.185984647498223 no 2772 0.219123549211591 3782 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1425 4048-4433 7.33 µM -0.778847773069954 0.184859122346205 no 2773 0.218034696120916 3853 23734946
SGTC_3229 9132204 49.47 µM -0.779052680683148 0.184796764588397 no 2774 0.217974341413384 3810 17682924
SGTC_1848 st056003 16.4 µM -0.779416692296638 0.184686020338671 no 2775 0.21786714702623 3834 146492
SGTC_782 0083-0095 30.5 µM -0.780234241755849 0.184437445472715 no 2776 0.217626505356877 3786 3591729 An indicator and reagent.
SGTC_1747 st037496 66.6 µM -0.781221805616953 0.184137455630321 no 2777 0.217336025425287 3809 723305
SGTC_2308 7584454 197.62 µM -0.781768076413572 0.183971646837928 no 2778 0.21717544271996 3821 893577
SGTC_346 4513-0042 7.16 µM -0.784459815164877 0.183155985614788 no 2779 0.216385176193575 3790 2827372
SGTC_60 0986-0278 202 µM -0.785457865703186 0.182854126560171 no 2780 0.216092582429895 3669 3110598
SGTC_438 sphingosine 6.67 µM -0.78582038226901 0.182744560828365 no 2781 0.215986361919484 3775 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2320 7373003 200 µM -0.785858518105371 0.182733037170403 no 2782 0.215975189546055 3872 5415828
SGTC_3070 9117005 49.47 µM -0.786014658784191 0.182685860249407 no 2783 0.215929449660154 3836 8779016
SGTC_1353 1498-1206 8.11 µM -0.787677081210961 0.182184041417076 no 2784 0.215442807376732 3853 6756808
SGTC_2129 girgensonine 121.053 µM -0.787775610182093 0.182154326532177 no 2785 0.215413984895041 3861 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2008 4012253 172 µM -0.788074464475559 0.182064215015586 no 2786 0.215326575333632 3826 603940
SGTC_158 k038-0087 26.446 µM -0.789366416435613 0.181674982216165 no 2787 0.214948939255749 3753 X158
SGTC_1172 0370-0043 85 µM -0.792172862525073 0.180831265837105 no 2788 0.214129944846514 3868 376585
SGTC_914 3820-6779 408 µM -0.793045172302342 0.180569519993 no 2789 0.213875752426901 3792 2893481
SGTC_42 0133-0086 60.653 µM -0.793398203660264 0.180463656747384 no 2790 0.213772928505196 3730 162923 Model of phenazepam hydroxylation.
SGTC_1840 st055363 71 µM -0.793403203672683 0.180462157677121 no 2791 0.21377147240826 3841 676033
SGTC_2561 acetosyringone 100 µM -0.793929482430904 0.180304415985472 no 2792 0.213618242515392 3834 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1410 3909-8106 77.9 µM -0.794354604011004 0.180177057360914 no 2793 0.213494512008318 3846 1039210
SGTC_747 3448-8087 38.7 µM -0.795541828049746 0.179821685956334 no 2794 0.213149194871284 3858 5168703
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.796394472217336 0.179566736081792 no 2795 0.212901395083181 3818 16486 A toxic proline analog.
SGTC_2251 lansoprazole 556 µM -0.799696792027362 0.178581451839854 no 2796 0.211943246024441 3757 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1682 st012968 530 nM -0.800314158355847 0.178397632119367 no 2797 0.211764400998515 3835 24207270
SGTC_2276 7947513 42.08 µM -0.801445382696841 0.17806112155548 no 2798 0.211436925559458 3721 2105100
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.802550907067018 0.177732643010144 no 2799 0.211117176665628 3832 1273210
SGTC_575 k072-0246 11.9 µM -0.80418432547731 0.17724801434004 no 2800 0.210645264940083 3864 6796779
SGTC_2203 7227154 166.4 µM -0.804776677029808 0.17707247240993 no 2801 0.210474281395647 3830 896304
SGTC_1201 1889-3372 45.9 µM -0.806264195930372 0.176632134255838 no 2802 0.210045265191024 3737 5392199
SGTC_2560 caryophyllene 100 µM -0.806399658301989 0.176592068857021 no 2803 0.210006221949861 3885 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1709 st033179 39.1045 µM -0.810464418093754 0.175392518471567 no 2804 0.208836653660177 3819 573381
SGTC_2467 5474540 200 µM -0.810552240564609 0.175366658341979 no 2805 0.208811426606156 3807 5413519
SGTC_794 k038-0031 316 µM -0.811294880623628 0.175148077843275 no 2806 0.208598174634319 3841 6624242
SGTC_1669 st015249 58.4 µM -0.812043280958917 0.174927976830586 no 2807 0.208383398520845 3924 722793
SGTC_51 1013-0126 23.419 µM -0.812224132878096 0.174874815476274 no 2808 0.20833151716685 3876 1627850
SGTC_1932 st074806 40.9 µM -0.813447940729463 0.174515347103492 no 2809 0.207980641231364 3908 17251235
SGTC_489 paxilline 115 µM -0.815645021476648 0.17387117832156 no 2810 0.2073515959527 3796 105008 A toxic potassium channel blocker.
SGTC_576 1073-0113 22.7 µM -0.817106363092813 0.173443561596747 no 2811 0.206933823459555 4007 5439563
SGTC_1242 0402-0103 60.1 µM -0.821504334464047 0.172160673384905 no 2812 0.205679528088974 3804 432868
SGTC_912 3474-0017 2.18 µM -0.822702034295497 0.171812356170204 no 2813 0.205338729104963 3898 3360550
SGTC_3134 9127454 49.47 µM -0.825210467706456 0.171084308591284 no 2814 0.204626055791848 3951 24262820
SGTC_2984 9022109 38.96 µM -0.825763158240555 0.170924161380455 no 2815 0.204469228451751 3890 6459207
SGTC_629 3448-6466 76.7 µM -0.826699625641505 0.170653030271851 no 2816 0.204203666803504 3865 573744
SGTC_582 0987-0078 156 µM -0.826798727075763 0.17062435400664 no 2817 0.204175575830469 3910 1625765
SGTC_584 0986-0246 15.4 µM -0.826802163851824 0.170623359586959 no 2818 0.2041746016943 3968 53315 YDR232W HEM1
SGTC_2807 7945238 51.95 µM -0.827528534458673 0.170413269940244 no 2819 0.20396877787335 3939 17148797
SGTC_2923 7992654 58.14 µM -0.827625043291364 0.170385368968433 no 2820 0.203941440511553 3889 2985126
SGTC_2789 5281112 71.43 µM -0.828437884953634 0.170150490293203 no 2821 0.2037112793563 3910 765948
SGTC_962 1254-0300 21.5 µM -0.829664570678524 0.169796420293055 no 2822 0.203364229045619 3838 7340576
SGTC_88 0180-0332 8.668 µM -0.830720468586644 0.169492025077138 no 2823 0.203065780236554 3938 3101745
SGTC_2841 9004761 38.96 µM -0.830937676827268 0.169429451536484 no 2824 0.203004418925725 3894 2991039
SGTC_3191 9110352 49.47 µM -0.832064253001298 0.169105144371526 no 2825 0.202686338932928 3829 17122424
SGTC_3172 9105863 49.47 µM -0.833857857366557 0.168589643111779 no 2826 0.202180543728949 3875 2348785
SGTC_949 1165-0505 146 µM -0.835941987282708 0.167991911953526 no 2827 0.201593770036784 3926 6244267
SGTC_289 k017-0060 526 µM -0.836462360391354 0.167842881329001 no 2828 0.201447421575878 3860 5512909
SGTC_1460 k062-0059 9.15 µM -0.838143983563418 0.16736186031161 no 2829 0.200974921498607 3787 1373085
SGTC_2790 5423970 71.43 µM -0.838304436619507 0.167316009882928 no 2830 0.200929872400337 3951 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_525 k781-2675 26.7 µM -0.8386451301424 0.167218681500467 no 2831 0.200834238745372 3878 3651118 YDL195W SEC31
SGTC_1416 3966-0321 25.3 µM -0.839075648573833 0.167095744395341 no 2832 0.200713430054761 3902 582530 YLR208W SEC13
SGTC_1667 st014849 34.6 µM -0.841250974757622 0.166475458453414 no 2833 0.200103674519176 3924 5348460
SGTC_793 0488-0545 106 µM -0.841530901903201 0.166395746387825 no 2834 0.200025290389032 3893 292548
SGTC_210 3551-0445 56.827 µM -0.841752398906768 0.166332690359928 no 2835 0.199963280728134 3915 2865180 YOR207C RET1
SGTC_1862 st057513 3.81 µM -0.842415830244507 0.166143916284591 no 2836 0.199777617580623 3860 5393163
SGTC_2310 7668677 200 µM -0.842763385062684 0.166045077610598 no 2837 0.19968039478133 3878 2197143
SGTC_2888 9058547 12.99 µM -0.84327825951635 0.165898725925617 no 2838 0.199536419374103 3812 16476514
SGTC_1229 0139-0193 12.2 µM -0.844635952569983 0.165513205229329 no 2839 0.19915706457954 3934 3090752
SGTC_1018 4259-0013 28.1 µM -0.844687560688452 0.16549856240266 no 2840 0.199142653263703 3983 6801262
SGTC_1070 indatraline 8.81 µM -0.845385888906332 0.165300507376695 no 2841 0.198947710275761 3873 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_3153 9100258 49.47 µM -0.84538866725194 0.165299719707946 no 2842 0.198946934911785 3824 25236848
SGTC_16 erodoxin 22.806 µM -0.845453107903035 0.165281451284608 no 2843 0.198928951713555 3909 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1335 1486-0900 202 µM -0.845672994214246 0.165219125061433 no 2844 0.198867596283596 3874 X1335
SGTC_2222 6885208 172.143 µM -0.848876990034167 0.164312686440142 no 2845 0.197974871898859 3842 609514
SGTC_770 0389-1121 67.2 µM -0.852932384727044 0.163170012041114 no 2846 0.196848400713242 4044 6753108
SGTC_2168 5727979 200 µM -0.853051484026232 0.163136532090392 no 2847 0.196815377146883 3831 695210
SGTC_1001 4048-4355 44.4 µM -0.853248735854132 0.163081092538164 no 2848 0.196760691015487 3893 21824233
SGTC_754 3474-0146 171 µM -0.853538151943746 0.162999771487899 no 2849 0.196680469906071 3890 24762078
SGTC_2936 9038235 15.59 µM -0.853735998922099 0.162944194989403 no 2850 0.196625641564985 3863 4749415
SGTC_2111 5486399 200 µM -0.854486074586657 0.162733605779798 no 2851 0.196417860964754 3863 689674
SGTC_3275 9138069 49.47 µM -0.855229614793194 0.162525026242279 no 2852 0.196212022165388 4009 17617007
SGTC_2922 7999257 32.47 µM -0.857209494835116 0.161970474633996 no 2853 0.195664558006053 3879 2988377
SGTC_1112 tnp00069 1.16933 µM -0.857523817512729 0.16188254839053 no 2854 0.195577728823637 3938 145826
SGTC_1530 rhein 70.4 µM -0.861656413152057 0.160729420269936 no 2855 0.194438308788936 3973 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2900 5328528 85.29 µM -0.861774295818692 0.160696606062279 no 2856 0.194405866117699 3941 795359
SGTC_2882 9058044 58.44 µM -0.863022910384934 0.160349306202169 no 2857 0.194062435315059 3919 18076804
SGTC_3241 9133421 49.47 µM -0.863609437708815 0.160186334148854 no 2858 0.193901238945253 3914 17018221
SGTC_2484 5809818 12.04 µM -0.865818700531627 0.159573442395297 no 2859 0.193294796165241 3911 2870548
SGTC_2937 9044753 11.33 µM -0.867784624335611 0.159029349776483 no 2860 0.192756124403614 3894 6465530 YGL099W LSG1
SGTC_2172 5754775 163.918 µM -0.86808482388717 0.158946373109132 no 2861 0.192673949204006 3907 2263357
SGTC_2581 avocatin a 64 µM -0.868569811088567 0.158812380157885 no 2862 0.192541236350113 3923 6710728 A skin care supplement.
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.871806870070436 0.157919937790293 no 2863 0.19165687304073 3930 6857784
SGTC_247 mechlorethamine 29.705 µM -0.872764930134487 0.157656437772401 no 2864 0.19139560925108 3832 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2472 5377652 49.4 µM -0.87429472832266 0.157236288959751 no 2865 0.190978884737349 4020 1610903
SGTC_2943 9068529 45.32 µM -0.875383538513671 0.156937703407437 no 2866 0.190682626792048 3929 3270634
SGTC_2878 9043973 25.97 µM -0.876967488870311 0.156504001528835 no 2867 0.19025214849532 4024 6465167
SGTC_2635 hydroquinidine 100 µM -0.87854523502185 0.156072783714018 no 2868 0.189823950391122 3872 442912 An experimental heart treatment.
SGTC_1071 trifluoperazine 6.31 µM -0.879634003522483 0.155775666648004 no 2869 0.189528806000365 4051 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_827 3253-0474 693 µM -0.880239641360382 0.155610553991938 no 2870 0.189364751410447 3949 5402065
SGTC_1695 st026914 34.495 µM -0.884177567745818 0.154539788996272 no 2871 0.188300182860965 3912 3289191
SGTC_977 1348-1378 135 µM -0.88488619815987 0.154347622942713 no 2872 0.188109006329615 3948 X977
SGTC_2728 chlorpromazine 9.18 µM -0.885092330222417 0.154291753826804 no 2873 0.18805341787598 3954 2726 A thorazine and dopamine antagonist.
SGTC_1363 1636-0063 10.4 µM -0.885686809971185 0.154130703590797 no 2874 0.187893158954032 3938 6072185
SGTC_318 1488-0629 67.2 µM -0.887124332598686 0.153741724708018 no 2875 0.187505982499739 3996 3662576
SGTC_368 fentichlor 4.58 µM -0.888461497388635 0.153380485508498 no 2876 0.187146278977043 4012 7329 A pesticide.
SGTC_2697 mebhydrolin 72.4 µM -0.889389590378458 0.153130089153038 no 2877 0.186896868739699 4034 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2721 ifenprodil 61.44 µM -0.891334907071652 0.152606128818759 no 2878 0.186374763574128 3929 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1436 4092-1007 8.32 µM -0.891460792679553 0.152572263248356 no 2879 0.186341008186971 3936 2881121
SGTC_300 r073-0011 5.04 µM -0.892939791887321 0.152174758393422 no 2880 0.185944708109974 3948 2735780
SGTC_1625 st003711 30.1 µM -0.895713980456229 0.151431006753836 no 2881 0.185202770846693 4038 24207034 YER133W GLC7
SGTC_1749 st037932 54.2 µM -0.89823707120285 0.15075667600947 no 2882 0.18452958678693 4030 594497
SGTC_2691 st077356 60.2 µM -0.89846458875447 0.150695967235011 no 2883 0.184468957882818 4038 2839272
SGTC_3335 9143315 29.6265 µM -0.899491993392726 0.15042202641036 no 2884 0.184195329311665 3972 4899691
SGTC_1702 st027038 51 µM -0.899900032920283 0.150313321377803 no 2885 0.184086726308735 3996 5521182
SGTC_2797 7859098 81.82 µM -0.900262311837038 0.150216851224883 no 2886 0.183990336275099 3963 972681
SGTC_517 1365-0151 113 µM -0.900335238376977 0.150197436828513 no 2887 0.183970936816531 4036 768657
SGTC_1159 4092-0538 61.2 µM -0.901516540513093 0.149883185272092 no 2888 0.183656871700301 4003 717301
SGTC_3140 9094243 49.47 µM -0.902637751253204 0.149585325201108 no 2889 0.18335909190636 3964 19291112
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.904126136381907 0.149190532446164 no 2890 0.182964260447834 3975 364106
SGTC_301 4119-0100 24.5 µM -0.904994516806087 0.148960517061009 no 2891 0.182734146027666 3996 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_389 tpck 16.7 µM -0.90506997762739 0.148940540299731 no 2892 0.182714158001933 3987 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1986 st071812 45 µM -0.906947449203254 0.148444093066521 no 2893 0.182217293781592 3907 11838594
SGTC_2218 6965428 192.983 µM -0.908414770523403 0.148056870394664 no 2894 0.181829562417713 3873 675684
SGTC_93 0109-0045 59.227 µM -0.910335727556267 0.147550956991588 no 2895 0.181322741073173 4065 88733
SGTC_2315 7733312 200 µM -0.912271065909844 0.14704242848289 no 2896 0.180813020872112 3922 726316
SGTC_36 0335-0881 14.2 µM -0.912510354230725 0.146979634941374 no 2897 0.180750060705473 3898 23828853
SGTC_2600 tangeritin 87.95 µM -0.912980746578506 0.146856247993711 no 2898 0.180626333847913 3922 68077 A bioactive flavone.
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.916370413594845 0.145969171131121 no 2899 0.179736323890772 4056 688664
SGTC_3066 9117245 49.47 µM -0.918319239986773 0.145460796054322 no 2900 0.179225878685631 4065 17176980
SGTC_3135 9127742 49.47 µM -0.918986980065277 0.145286882167338 no 2901 0.179051191181081 4075 3643468
SGTC_2855 9016525 58.44 µM -0.919830996804083 0.145067257007723 no 2902 0.178830541267225 3955 43811474
SGTC_2127 5253358 187.912 µM -0.925011313193448 0.143724161260227 no 2903 0.177480011359229 3907 20612
SGTC_2749 bexarotene 57.39 µM -0.925163209206237 0.143684906361834 no 2904 0.17744050884163 4046 82146 An retinoic acid receptor inhibitor.
SGTC_956 1185-0240 191 µM -0.925369430980234 0.143631623490216 no 2905 0.177386887092802 3997 1416193
SGTC_1610 st001799 48.1 µM -0.925564455968403 0.143581245875941 no 2906 0.177336186143737 3914 621897
SGTC_485 niflumic acid 177 µM -0.9283737295634 0.142856895396538 no 2907 0.176606870374024 4059 4488 A COX2 inhibitor.
SGTC_454 lyso-paf C-16 6.67 µM -0.931242032246594 0.142119877123128 no 2908 0.175864189971975 3986 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3232 9132874 49.47 µM -0.931431760716284 0.142071216780079 no 2909 0.175815134035764 3960 3784940
SGTC_1557 sumaresinolic acid 42.3 µM -0.932150149254305 0.141887071288117 no 2910 0.175629467019525 3967 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1912 st060209 90.8 µM -0.932970083961903 0.141677093909025 no 2911 0.175417707351588 4040 688787
SGTC_1723 st034307 2.5525 µM -0.937053551818711 0.140634492632371 no 2912 0.174365506076724 4071 867466
SGTC_2290 7904846 200 µM -0.937621549291836 0.140489883694538 no 2913 0.174219466509509 4067 2962154
SGTC_3288 9119690 36.221 µM -0.939047025294521 0.140127410285795 no 2914 0.173853300461641 4022 17595618 YKL019W RAM2
SGTC_148 3253-0744 288.01 µM -0.939764917730965 0.139945103661601 no 2915 0.173669078853962 3927 6893655
SGTC_709 3807-1509 243 µM -0.939958748262458 0.139895908628955 no 2916 0.173619360430275 4088 1886677 YPL242C IQG1
SGTC_1614 st002383 48.6 µM -0.940635170862789 0.139724321714916 no 2917 0.173445925878045 4021 1947235
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.943295524468085 0.13905086293694 no 2918 0.172764882226881 4022 4620898
SGTC_2505 galangin 7.89 µM -0.943542463164853 0.13898846356927 no 2919 0.172701753123965 3908 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2265 7929201 200 µM -0.943648327983545 0.138961718243736 no 2920 0.172674693619332 3985 1265108
SGTC_2015 5119600 184 µM -0.944380739271658 0.138776780341558 no 2921 0.17248756017476 4076 2828786
SGTC_2262 9014885 67.46 µM -0.944849082060877 0.138658609102238 no 2922 0.172367964905688 3963 6457424
SGTC_1697 st025554 27.742 µM -0.944979167218998 0.138625798464149 no 2923 0.172334755955827 3993 1269519
SGTC_1168 k815-0004 80.5 µM -0.948031021666183 0.1378575640756 no 2924 0.171556830908152 4016 642433
SGTC_256 clotrimazole 625 nM -0.94847831799924 0.137745212001733 no 2925 0.171443002819155 3952 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_341 1486-1430 230 µM -0.948591673424352 0.137716749266673 no 2926 0.171414163768763 4010 2054753 YPL210C SRP72
SGTC_3248 9135562 49.47 µM -0.949018623210342 0.137609581263062 no 2927 0.171305570190862 4013 17650701
SGTC_674 0498-0004 451 µM -0.95241340610092 0.136759487840069 no 2928 0.170443681581737 4027 4231473
SGTC_2210 7115885 190.385 µM -0.953122307747665 0.136582424650792 no 2929 0.170264052338641 4089 2927039
SGTC_681 1642-0006 26.6 µM -0.953458169043847 0.136498590939585 no 2930 0.170178990492565 4057 4446530
SGTC_277 nystatin 15.5 µM -0.95346356944209 0.136497243243823 no 2931 0.170177622984229 4014 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_555 4296-0685 37 µM -0.954054394373876 0.136349854957605 no 2932 0.170028054688294 3982 2908540 YHR072W ERG7
SGTC_1019 4262-0212 3.4 µM -0.955026211558122 0.136107660547449 no 2933 0.16978222091898 4060 4677213
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.957668726269237 0.135450587672353 no 2934 0.169114915736549 3949 5355888
SGTC_94 0334-0113 514.748 µM -0.960317502025217 0.134794142813465 no 2935 0.16844772205548 4064 6795178
SGTC_1893 st059353 36.1 µM -0.961288347607714 0.134554086160572 no 2936 0.168203602579794 4047 3112488
SGTC_2802 7925815 54.55 µM -0.961453881271371 0.134513184692758 no 2937 0.168162001803135 4018 1262923
SGTC_3356 9151811 4.48 µM -0.962575537817693 0.134236261100898 no 2938 0.167880289248024 4040 1859254 YPR165W RHO1
SGTC_2324 6149169 200 µM -0.964696592677544 0.133713668944691 no 2939 0.167348401195504 3949 2888231
SGTC_1802 st050112 57.9 µM -0.965615276658386 0.133487755374285 no 2940 0.167118364080467 4044 4662563
SGTC_860 0443-0016 25.1 µM -0.966832210721091 0.133188903523048 no 2941 0.166813959640273 4075 5337942
SGTC_600 1495-0418 41.6 µM -0.967039280664974 0.133138097638835 no 2942 0.166762198704563 4043 5377768
SGTC_2086 5274770 176.623 µM -0.96799628843652 0.132903463176072 no 2943 0.166523111670524 4089 689278
SGTC_2706 st078239 82.5 µM -0.968032957676948 0.132894478458916 no 2944 0.166513955082895 4018 15434492
SGTC_2053 5265679 138 µM -0.970221192949963 0.132359072874425 no 2945 0.16596812457788 3978 764595
SGTC_1461 k072-0203 53.8 µM -0.971156686476587 0.132130635623289 no 2946 0.165735129534139 3958 5418714
SGTC_2062 5245942 200 µM -0.976299546456626 0.13087966157225 no 2947 0.16445802232386 4121 1376160
SGTC_1845 st056753 3.01 µM -0.976319197043008 0.130874897419213 no 2948 0.164453154832656 4026 5375839
SGTC_2433 5607874 27.82 µM -0.977959511019104 0.130477636777759 no 2949 0.164047174890646 4042 2252428
SGTC_1052 3253-3998 198 µM -0.977976656467138 0.130473488803691 no 2950 0.164042934805299 3997 5450317
SGTC_1724 st037281 8.293 µM -0.979928596482354 0.130001854811429 no 2951 0.163560683010098 4037 574124 YDL195W SEC31
SGTC_408 cantharidin 100 µM -0.981785897069182 0.12955418478572 no 2952 0.163102668709692 4021 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_493 zm226600 134 µM -0.982704583974194 0.129333146493817 no 2953 0.162876426990276 4111 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2869 9037858 32.47 µM -0.983006416700476 0.129260581884009 no 2954 0.16280214028692 4023 27187042
SGTC_2035 5154463 94.595 µM -0.984532936058995 0.128894018582632 no 2955 0.162426772778198 4094 2769623
SGTC_364 0083-0097 67.7 µM -0.984959410912098 0.128791738097817 no 2956 0.162322004361657 4161 5207356
SGTC_1072 oxiconazole 14.9 nM -0.986106535547523 0.128516905280789 no 2957 0.162040418443107 4070 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_90 0870-0863 4.608 µM -0.986586261496626 0.128402091370658 no 2958 0.1619227540014 4084 1738164
SGTC_1694 st024011 44.9 µM -0.986731938923111 0.128367240157718 no 2959 0.161887034094612 4089 2787533
SGTC_1161 k007-0610 110 µM -0.989858410932654 0.127620859646271 no 2960 0.161121664937888 4053 5843850
SGTC_1817 st052116 64.4 µM -0.993598201346591 0.12673203172227 no 2961 0.160209260102184 4096 4361398
SGTC_719 2810-4230 27.3 µM -0.997594184630676 0.125787088549896 no 2962 0.159238091075692 4077 721079
SGTC_3167 9103034 49.47 µM -0.99839586042071 0.125598107089122 no 2963 0.159043720074806 4132 5127859
SGTC_2525 harmine 47.85 µM -0.998502731559348 0.125572929005561 no 2964 0.159017820287272 4069 5280953 A monoamine oxidase inhibitor
SGTC_1465 k213-0056 144 µM -1.00357363912087 0.124382305490449 no 2965 0.157792082972471 3963 24048857 YMR208W ERG12
SGTC_1791 st048313 56.1 µM -1.00441968735938 0.124184428629759 no 2966 0.157588182255344 4095 1204976
SGTC_925 2064-1272 59.6 µM -1.00533813575184 0.123969867965652 no 2967 0.157367028901425 4072 6815817
SGTC_422 cantharidin 155 µM -1.00683658283589 0.123620369746879 no 2968 0.157006655703932 4016 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.00734907755268 0.123500993835464 no 2969 0.156883526544032 4055 2333 A French combination drug.
SGTC_1331 1472-0049 76.2 µM -1.00918718085765 0.12307350678438 no 2970 0.156442436663515 4030 24051409
SGTC_520 3584-0023 682 µM -1.01090272367804 0.122675460349459 no 2971 0.156031495154991 4100 1340790
SGTC_2113 5491891 107.031 µM -1.01110346913649 0.122628941748888 no 2972 0.155983455079625 4112 789979
SGTC_1663 st014140 55.4 µM -1.01176122267139 0.122476607701099 no 2973 0.155826117440137 4176 4207120
SGTC_231 b-estradiol 524 µM -1.01179938858746 0.122467772649754 no 2974 0.155816991192283 4084 450 A steroid.
SGTC_1273 0849-0096 14.1 µM -1.01289093452138 0.122215279297305 no 2975 0.155556129497099 4124 5286025
SGTC_2619 obliquin 87.91 µM -1.01341234430883 0.122094797314265 no 2976 0.155431622786147 4050 6708593 A bioactive alkalod. YER133W GLC7
SGTC_3184 9108758 49.47 µM -1.0139583380809 0.121968724137963 no 2977 0.155301316197134 4117 902885
SGTC_2469 5655019 90.81 µM -1.01417255096628 0.121919286103764 no 2978 0.155250211959807 4151 2788239
SGTC_3029 9088683 49.47 µM -1.01531155579846 0.121656652417485 no 2979 0.154978668837435 4151 25236615
SGTC_463 ikarugamyin 104 µM -1.01579129891913 0.121546151509682 no 2980 0.154864390170583 4196 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1051 3253-3903 78 µM -1.01579682284598 0.121544879575294 no 2981 0.154863074651045 4083 5509239
SGTC_748 act1.228 77.9 µM -1.01654084854708 0.121373646379877 no 2982 0.154685952875232 4042 4421505 YNR035C ARC35
SGTC_3094 9117742 49.47 µM -1.01655707348818 0.121369914194557 no 2983 0.154682091879145 4033 17149698
SGTC_1466 k213-0079 57.5 µM -1.01727074393715 0.121205830076155 no 2984 0.154512325064245 4024 3657981
SGTC_540 1187-0821 17.3 µM -1.01902219687841 0.120803804825847 no 2985 0.154096214365143 4060 847520
SGTC_340 k038-0059 454 µM -1.01975469146414 0.120635948027087 no 2986 0.153922408142271 4089 23733424
SGTC_1080 nisoldipine 24.4 µM -1.02233196411025 0.120046651632997 no 2987 0.15331190481426 4107 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1774 st048371 48.465 µM -1.02251440706217 0.120005012867042 no 2988 0.153268748686694 4098 4242727
SGTC_1485 3909-9022 254 µM -1.02331458536969 0.119822509237717 no 2989 0.153079564888076 4145 714516
SGTC_2389 9091542 195.52 µM -1.02475525089626 0.11949441764098 no 2990 0.152739342947429 4098 3626624 YOL127W RPL25
SGTC_3301 9125354 19.7965 µM -1.02710437105808 0.118960798310392 no 2991 0.152185660330941 4086 41905162
SGTC_175 3793-3120 23.7 µM -1.02718002850528 0.118943640199457 no 2992 0.152167850211641 4122 5322297
SGTC_888 0916-0002 6.97 µM -1.02956752700035 0.118403084562278 no 2993 0.151606532762153 4167 2802138 YIL048W NEO1
SGTC_3052 9092717 49.47 µM -1.03394196770662 0.117417174085814 no 2994 0.15058164689019 4137 25237534
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.03667505406887 0.116804150149447 no 2995 0.149943660840108 4098 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2108 5365811 200 µM -1.03737288221299 0.116647993424032 no 2996 0.149781055673158 4139 780283
SGTC_2558 carylophyllene oxide 100 µM -1.03768805045455 0.116577515094731 no 2997 0.149707654983663 4249 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2731 amoxapine 43.43 µM -1.03774106455341 0.116565662981175 no 2998 0.149695310693642 4240 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_371 0195-0006 7.36 µM -1.04120767034593 0.115792504315858 no 2999 0.148889588296087 3969 3928593
SGTC_3206 9114350 49.47 µM -1.04177933689192 0.115665355888554 no 3000 0.148756998122577 4031 17087243
SGTC_3304 9125678 46.087 µM -1.04178542455621 0.115664002421683 no 3001 0.148755586597579 4072 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2785 7756463 72.73 µM -1.04296528245707 0.115401897648063 no 3002 0.148482186147581 4096 2201551
SGTC_1493 4348-0038 111 µM -1.04516728914959 0.114913852698679 no 3003 0.147972829406823 4111 800424
SGTC_21 0849-0113 22.993 µM -1.04626492036287 0.11467112665254 no 3004 0.147719368377702 4101 1560156
SGTC_3147 9097027 49.47 µM -1.04752232090457 0.114393518433123 no 3005 0.147429371500858 4136 25236841
SGTC_854 0422-0053 192 µM -1.04884010018854 0.114103093669187 no 3006 0.147125859003515 4151 3596728
SGTC_204 PMA1.184 62.41 µM -1.0494500701285 0.113968840645558 no 3007 0.146985511931482 4141 2252213 YGL008C PMA1
SGTC_3036 9090181 49.47 µM -1.05381123627649 0.113012236006899 no 3008 0.145984674058565 4185 25236586
SGTC_1805 st050013 60.3 µM -1.05854025383417 0.111981435766716 no 3009 0.144904604496235 4087 4037144
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.06002270042293 0.11165969005099 no 3010 0.144567136069175 4101 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1902 st060212 70.5 µM -1.06054734231017 0.111545981961945 no 3011 0.144447832026489 4160 688944
SGTC_428 3448-4153 16.5 µM -1.06178921768807 0.111277154758371 no 3012 0.1441656928922 4123 3834874
SGTC_2862 9027634 71.43 µM -1.06239084295846 0.111147088594702 no 3013 0.144029144560612 4099 5012562
SGTC_1864 st057645 30.4 µM -1.0647462265066 0.11063892255238 no 3014 0.143495392544537 4194 688666
SGTC_1965 Pectolinarigenin 58.4 µM -1.0655643217548 0.110462811482631 no 3015 0.143310317319971 4122 5320438 An anti-inflammatory.
SGTC_3159 9100096 49.47 µM -1.06601232275164 0.110366455674939 no 3016 0.143209035740688 4093 25236875
SGTC_1154 4088-0362 150 µM -1.06662688983647 0.110234372991694 no 3017 0.143070176493438 4158 6618304
SGTC_1440 4100-1550 40 µM -1.06874227370794 0.109780601760491 no 3018 0.142592908633581 4159 742806
SGTC_800 3448-7362 155 µM -1.07215460503432 0.109051450711527 no 3019 0.141825298000056 4234 15991913
SGTC_2385 9074692 200 µM -1.07322626830124 0.108823176255671 no 3020 0.141584803730236 4178 17046906
SGTC_387 norethindrone acetate 66.7 µM -1.07339244857544 0.108787809070357 no 3021 0.1415475356141 4179 541197
SGTC_2047 4141938 200 µM -1.0765871362479 0.108109508243448 no 3022 0.140832376816197 4166 3807862
SGTC_2963 9082507 9 µM -1.07690733794385 0.108041690794454 no 3023 0.140760832271515 4210 16459611
SGTC_2627 acetyl isogambogic acid 100 µM -1.07915271529572 0.10756698915402 no 3024 0.140259827310517 4203 6857789 A caspase activator and apoptosis inducer.
SGTC_1348 1493-0373 93.8 µM -1.07945013009633 0.107504224738567 no 3025 0.14019355690095 4175 3010129
SGTC_413 propylparaben 100 µM -1.08404874086395 0.106537122037315 no 3026 0.139171594249025 4133 7175 A pharmaceutical preservative.
SGTC_2759 disulfiram 3.38 µM -1.0853966002735 0.106254856698557 no 3027 0.138873018748303 4083 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_672 1441-0018 53.7 µM -1.08642921665563 0.106038974476599 no 3028 0.138644570639492 4171 251141
SGTC_1684 st024538 14.6195 µM -1.08774835475216 0.105763652331252 no 3029 0.13835310727719 4136 6732859
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.08923128429934 0.105454762091123 no 3030 0.138025953190124 4155 6312947
SGTC_2390 9097792 176.6 µM -1.09002757734362 0.105289165898453 no 3031 0.137850498192248 4196 4497149
SGTC_496 calpeptin 138 µM -1.09152707688915 0.104977842553889 no 3032 0.137520512072895 4193 73364 A calpain inhibitor.
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.09264760480351 0.104745636018674 no 3033 0.137274276349528 4163 688667
SGTC_1964 st076914 61 µM -1.0951174545702 0.104235124090996 no 3034 0.136732591362921 4228 24208661
SGTC_1134 3477-0009 42.5 µM -1.09638310365441 0.103974217484681 no 3035 0.136455577507997 4265 3973534
SGTC_954 1189-0853 2.85 µM -1.09755465803343 0.103733130361099 no 3036 0.136199500607789 4129 2828194
SGTC_995 3931-2021 34.6 µM -1.09825544851415 0.103589112895699 no 3037 0.136046479989237 4198 730143
SGTC_2431 5490079 200 µM -1.09903120176539 0.103429859309539 no 3038 0.135877228216052 4249 5722345
SGTC_244 nsc-207895 1.295 µM -1.10142617012888 0.102939320109872 no 3039 0.135355610363382 3972 42640
SGTC_264 promethazine 12.5 mM -1.10216693613766 0.102787938644335 no 3040 0.135194551735465 4073 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1415 3966-0071 78.1 µM -1.10439301276151 0.102333995721631 no 3041 0.134711345227938 4136 2893185
SGTC_602 3130-1533 38.1 µM -1.10470239500373 0.102271021879023 no 3042 0.134644282649177 4247 720941
SGTC_950 1165-0508 94.1 µM -1.10549607658996 0.10210959924713 no 3043 0.134472346760336 4222 6148369
SGTC_991 3996-0057 64.7 µM -1.10832806351496 0.101535127481903 no 3044 0.133860079911749 4260 715343
SGTC_1372 2752-0194 270 µM -1.10861384519429 0.101477287353063 no 3045 0.133798401393883 4134 823334
SGTC_519 k048-0011 62.8 µM -1.10885779089578 0.101427933510108 no 3046 0.133745767537196 4242 6836379
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.11046769315325 0.101102664728542 no 3047 0.133398771091221 4222 2374 Ca(2+)-ATPase inhibitor.
SGTC_3294 9122953 26.2835 µM -1.11359251293176 0.100473489314648 no 3048 0.132727019928985 4185 16459826
SGTC_721 1187-1332 279 µM -1.11564444962565 0.100061893337197 no 3049 0.132287178758842 4165 25730
SGTC_1839 st053978 48 µM -1.11628989991361 0.0999326779837574 no 3050 0.132149031764099 4220 3788398
SGTC_335 4077-0256 27.6 µM -1.11793066681951 0.0996047548147898 no 3051 0.131798303117077 4174 3121989
SGTC_232 clozapine 119 µM -1.12016793039875 0.0991588840609178 no 3052 0.131321103620771 4170 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3220 9131269 49.47 µM -1.12053239861287 0.0990863866094323 no 3053 0.131243477143863 4234 17722206
SGTC_2502 avocadyne acetate 18.59 µM -1.12143524514651 0.0989069657106452 no 3054 0.13105132034522 4153 3952079
SGTC_400 oxethazaine 37.5 µM -1.12767469810479 0.0976735055762752 no 3055 0.129728663512832 4218 4621 A local anesthetic.
SGTC_202 3594-0513 34.79 µM -1.13229083360496 0.09676823990872 no 3056 0.128756091278913 4267 708429
SGTC_2403 6032726 181.2 µM -1.13518278373859 0.0962042505678158 no 3057 0.128149370713933 4274 2881040
SGTC_975 1335-0046 28.5 µM -1.13590088503941 0.0960645813813145 no 3058 0.127999023934192 4245 16486740
SGTC_2089 5281248 129.67 µM -1.13599131699456 0.0960470031323704 no 3059 0.127980099150192 4214 2737878
SGTC_1819 st053448 58.6 µM -1.13754018308361 0.0957463001379396 no 3060 0.127656268175208 4121 2857616
SGTC_448 monastrol 171 µM -1.14049602499392 0.0951743643946014 no 3061 0.127039853904999 4151 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_483 fpl-64176 144 µM -1.1443839606129 0.0944259110531899 no 3062 0.126232218522845 4342 3423
SGTC_980 1473-0395 201 µM -1.14564621363585 0.0941838546907158 no 3063 0.125970783642436 4115 768876
SGTC_14 0354-0009 295 µM -1.14685678187427 0.0939521399744868 no 3064 0.125720408494512 4324 1713507
SGTC_1195 1502-0147 41.1 µM -1.14690934350092 0.0939420886983568 no 3065 0.125709545332764 4220 817940
SGTC_3171 9103192 49.47 µM -1.1477164903861 0.0937878389330809 no 3066 0.125542810674483 4310 13018434
SGTC_1300 1094-0077 113 µM -1.15636902046858 0.0921460276727811 no 3067 0.123765123808762 4217 5532636
SGTC_2197 6588183 93.1375 µM -1.16051399450669 0.0913671015772712 no 3068 0.122919799667776 4208 884136
SGTC_645 0845-0943 5.41 µM -1.16347249158591 0.0908141315676447 no 3069 0.122318926353389 4262 1885106
SGTC_272 doxorubicin 8.13 µM -1.16476592802042 0.0905731582159364 no 3070 0.122056877072148 4258 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2329 6138490 200 µM -1.16519669827045 0.0904930091299799 no 3071 0.121969690910208 4333 720019
SGTC_369 0957-0393 4.5 µM -1.16526479118005 0.0904803445886236 no 3072 0.121955913184446 4276 6997992
SGTC_1189 1431-2119 7.28 µM -1.16571156401554 0.090397282335995 no 3073 0.121865541554407 4248 3107275
SGTC_1156 4092-0367 4.88 µM -1.16937644479422 0.0897180582954033 no 3074 0.121125997944162 4281 1357585
SGTC_2699 st077704 54.6 µM -1.17498264952521 0.0886863945860964 no 3075 0.120000828677899 4270 645852
SGTC_664 1222-0054 14.9 µM -1.17556027740666 0.0885806026078507 no 3076 0.119885318364058 4234 6813991
SGTC_89 0302-0250 142.109 µM -1.17837964146098 0.0880655877450417 no 3077 0.119322645119189 4361 4203518 YLR208W SEC13
SGTC_679 0422-0091 41.4 µM -1.17867356161338 0.0880120259483931 no 3078 0.119264093594359 4283 627384 YHR062C RPP1
SGTC_3350 9150499 3.57 µM -1.17910255441095 0.0879338931343705 no 3079 0.119178670791888 4272 4910996 YPR165W RHO1
SGTC_1429 4049-0205 9.46 µM -1.18274186526805 0.0872731420734958 no 3080 0.1184557333668 4291 22774478
SGTC_2665 lovastatin 100 µM -1.18468846663637 0.0869212434675791 no 3081 0.118070322105239 4295 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1761 st044296 37 µM -1.18500593128726 0.0868639541856919 no 3082 0.1180075508969 4263 1826700
SGTC_1850 st056238 17 µM -1.18545287496353 0.0867833471003141 no 3083 0.117919218257278 4289 5393177
SGTC_2610 ononetin 44.17 µM -1.18700286767747 0.0865042361861237 no 3084 0.117613244684295 4253 259632
SGTC_47 0149-0135 24.25 µM -1.18740642081796 0.0864316776302108 no 3085 0.117533674280363 4283 5239155
SGTC_3305 9127027 53.8275 µM -1.19450737230369 0.0851623665052107 no 3086 0.116139779306129 4215 41905295
SGTC_3148 9097893 49.47 µM -1.1945354688431 0.0851573720797916 no 3087 0.116134287445169 4244 17174100
SGTC_3053 9095903 49.47 µM -1.19664732519594 0.0847825976056131 no 3088 0.115722023090949 4402 17174018
SGTC_2128 5255449 168.493 µM -1.19813838791773 0.0845187362748708 no 3089 0.115431573202227 4221 736008
SGTC_708 3448-5400 146 µM -1.1990687126404 0.0843544166024563 no 3090 0.115250614301706 4241 3462195
SGTC_905 2-aminofluorene 215 µM -1.20067900014529 0.0840705644800036 no 3091 0.114937871574362 4298 1539 An established DNA mutagen. YPR165W RHO1
SGTC_205 1486-1330 71.903 µM -1.20156418088434 0.0839148357170073 no 3092 0.114766213116475 4338 4118834
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.202250137385 0.0837943052879056 no 3093 0.114633314669297 4246 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1387 3342-1166 1.8 µM -1.2079273052325 0.0828017489823016 no 3094 0.113537612781889 4259 3418228
SGTC_1613 st002381 52.1 µM -1.20887351371615 0.0826371841395906 no 3095 0.113355721594219 4279 551167
SGTC_1950 st077106 7.18 µM -1.20990140531415 0.0824586920327783 no 3096 0.113158363964032 4219 13831864
SGTC_1567 st069303 68.4 µM -1.2133413203335 0.08186346592691 no 3097 0.112499675567019 4326 5581319
SGTC_246 cycloheximide 667 µM -1.2203407434727 0.0806623264153504 no 3098 0.111167865277652 4203 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1328 1441-0025 69.2 µM -1.22148642799832 0.0804669947640784 no 3099 0.110950950601657 4284 4562601
SGTC_1375 2910-0797 186 µM -1.22786217570547 0.0793864945944832 no 3100 0.109749355275747 4307 742508
SGTC_2391 6285546 200 µM -1.22811988140116 0.0793430531653889 no 3101 0.109700984360691 4319 846083
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.22818056679848 0.0793328260507496 no 3102 0.109689596042861 4361 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_336 4111-0029 111 µM -1.22891489133773 0.0792091517817803 no 3103 0.109551858804619 4313 3131175
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.23057147856012 0.0789306870504158 no 3104 0.109241589002032 4329 165521
SGTC_262 fenpropimorph 62.5 µM -1.2315942331657 0.0787591373057452 no 3105 0.10905034810962 4320 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_353 1988-1175 58.3 µM -1.23219564735417 0.0786583922673364 no 3106 0.108938004427249 4152 2788357
SGTC_2202 7226349 200 µM -1.23871249396348 0.0775729867888044 no 3107 0.107725995046027 4294 844334
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.24781706249651 0.0760756788910974 no 3108 0.10604902935962 4282 676296 Flavone; oxidizing agent.
SGTC_2264 7948757 110.76 µM -1.25056547486412 0.0756280349305405 no 3109 0.105546526699643 4283 2971411
SGTC_2056 5235370 200 µM -1.25371831216335 0.0751169954431627 no 3110 0.104972204766882 4241 5511916
SGTC_1863 st057641 20.1 µM -1.25494043935329 0.0749196120814621 no 3111 0.104750191169655 4355 3921635
SGTC_1174 0739-0097 51.1 µM -1.25700552571296 0.074586983475465 no 3112 0.104375817345455 4373 728447
SGTC_828 2074-0507 139 µM -1.25713992621427 0.0745653743812694 no 3113 0.104351485896576 4405 X828
SGTC_3059 1327-0034 3 µM -1.25776832846247 0.0744644024176811 no 3114 0.104237776445615 4181 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_609 0986-0026 86.3 µM -1.25806860436237 0.0744161908184413 no 3115 0.10418347321324 4298 2848610
SGTC_2903 5923464 63.88 µM -1.26093638558383 0.0739569465075446 no 3116 0.103665883785989 4345 2876576
SGTC_510 ag-490 170 µM -1.26198054911688 0.0737902737986933 no 3117 0.103477892773033 4465 5328779
SGTC_655 k060-0012 42 µM -1.26922331201182 0.0726420532568121 no 3118 0.102180714420266 4317 5994525
SGTC_135 0933-0004 26.348 µM -1.27118758338075 0.0723330214680731 no 3119 0.10183096139033 4297 21230617 YGL099W LSG1
SGTC_3011 9081274 71.4286 µM -1.27235825088975 0.0721493242243212 no 3120 0.101622930264632 4333 6625322
SGTC_1245 0418-0076 17.2 µM -1.27894280774577 0.0711227528795075 no 3121 0.100458598301348 4369 6790114
SGTC_767 0929-0023 86 µM -1.27923120137633 0.0710780483248626 no 3122 0.100407825743637 4373 1204563
SGTC_2836 9010338 19.48 µM -1.28128359828668 0.0707605245890979 no 3123 0.10004703588214 4325 2994051
SGTC_2312 7706453 155.7 µM -1.28383017098751 0.0703680640259613 no 3124 0.0996006921945952 4339 976098
SGTC_3352 9151559 45.5865 µM -1.28498003667855 0.0701914039168541 no 3125 0.0993996301195718 4369 17159339
SGTC_2026 5148700 152 µM -1.28896528653908 0.0695817675078842 no 3126 0.0987050775352038 4343 79838
SGTC_1399 3562-5772 25 µM -1.29359594211895 0.068878531269573 no 3127 0.0979025124284672 4349 23847490
SGTC_378 3970-0959 8.33 µM -1.29412826593186 0.0687980421094246 no 3128 0.0978105597686238 4379 6615653
SGTC_1488 4013-0813 75.9 µM -1.29879736113146 0.0680951636235476 no 3129 0.0970067402567479 4324 2910057
SGTC_2566 crystal violet carbinol 226 nM -1.29980758604398 0.0679438179078317 no 3130 0.0968334624184746 4363 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2192 5915882 198.485 µM -1.30169407677331 0.0676618909726456 no 3131 0.0965104926147695 4339 2876149
SGTC_441 propafenone 146 µM -1.30196886552535 0.0676209006387562 no 3132 0.0964635145160975 4353 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_145 3737-0113 38.366 µM -1.30386157250468 0.0673390858771352 no 3133 0.0961403922176626 4338 6849351
SGTC_904 1141-0088 396 µM -1.30406527887292 0.0673088091948211 no 3134 0.0961056630206428 4372 1378119
SGTC_1923 st058458 19.1 µM -1.30409478601109 0.067304424449843 no 3135 0.0961006332151841 4377 3534982
SGTC_2353 9059630 146.67 µM -1.30458990918792 0.0672308823443571 no 3136 0.0960162630734751 4403 4779114
SGTC_298 1391-0729 10 µM -1.30602344202137 0.0670183058139666 no 3137 0.0957722929049134 4306 3237558
SGTC_120 rhodamine 6G 52.259 µM -1.30723588856906 0.066838919950955 no 3138 0.0955663051949861 4382 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_717 1532-0246 73.2 µM -1.30769904937587 0.0667704917732622 no 3139 0.0954877029555458 4342 9561992
SGTC_1236 0330-0013 258 µM -1.30805806475751 0.0667174875244414 no 3140 0.0954268078048658 4385 4617066
SGTC_1326 1431-2094 10.8 µM -1.3091572041748 0.0665554154019005 no 3141 0.0952405526867223 4362 616278
SGTC_955 1216-0110 33 µM -1.3097301354433 0.0664710555104577 no 3142 0.0951435725798551 4345 3619719
SGTC_1187 1391-0724 117 µM -1.31495986709996 0.065704838134446 no 3143 0.0942616953634058 4425 6997986
SGTC_1397 3532-0190 20.1 µM -1.31750251902517 0.0653347919468527 no 3144 0.0938351186288213 4330 5322280
SGTC_881 0833-0569 170 µM -1.32089340813269 0.0648438152607738 no 3145 0.0932684540100186 4398 5418700
SGTC_3031 9088762 49.47 µM -1.32173064103997 0.0647230319491782 no 3146 0.0931289307882674 4342 205253
SGTC_921 1561-0023 372 µM -1.32317065310426 0.0645156975371428 no 3147 0.0928893165127617 4366 24050882
SGTC_313 3474-0040 5.03 µM -1.32620280912786 0.0640808120023316 no 3148 0.092386264538881 4389 1043375 YIL048W NEO1
SGTC_423 5-fluorouracil 457 µM -1.32630842667164 0.0640657050332902 no 3149 0.0923687783917151 4318 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1069 diphenylcyclopropenone 8.49 µM -1.32657330914969 0.0640278298393136 no 3150 0.0923249349550991 4417 65057 A dermal irritant. YDR527W RBA50
SGTC_948 3448-0295 75.3 µM -1.332827888936 0.0631385455625327 no 3151 0.0912941456355085 4366 678569
SGTC_2193 5925765 200 µM -1.3335835902385 0.0630317534605565 no 3152 0.091170181919635 4401 877370
SGTC_140 0062-0056 502.533 µM -1.33430168578686 0.0629304060378448 no 3153 0.0910525026772106 4299 3758964
SGTC_348 k064-0012 10.7 µM -1.33439357568716 0.0629174464506414 no 3154 0.0910374521835525 4321 5066323
SGTC_3307 9126885 69.2785 µM -1.33637821718936 0.062638051899441 no 3155 0.0907128412224562 4359 24824909
SGTC_1662 st014054 52 µM -1.34218393311372 0.0618262833743475 no 3156 0.0897681823339699 4452 2838777
SGTC_460 trequinsin 123 µM -1.34295550882141 0.0617190208982245 no 3157 0.0896431903563286 4482 5537 A vasodilator.
SGTC_469 w7 172 µM -1.34373221850496 0.0616111915021745 no 3158 0.0895174974397884 4486 45115570 A P450 inhibitor.
SGTC_1474 0330-0125 5.35 µM -1.34676856040356 0.0611910719286701 no 3159 0.0890273916723795 4447 X1474
SGTC_2956 9076196 2.52 µM -1.34708259065976 0.0611477495806414 no 3160 0.0889768172199682 4393 16423868
SGTC_1045 1348-1485 165 µM -1.34911345888286 0.0608681577052201 no 3161 0.0886502629534258 4375 6810614
SGTC_349 k015-0014 24 µM -1.35562317873484 0.0599786908804389 no 3162 0.0876095465584723 4420 2196908
SGTC_923 1900-2434 73.3 µM -1.35591177861484 0.0599394944386486 no 3163 0.0875636197057741 4379 5910570
SGTC_1258 0671-0043 57.1 µM -1.36101414517752 0.0592498197517738 no 3164 0.0867546096738121 4419 4298767
SGTC_1471 k673-0312 37 µM -1.36429041306449 0.0588102653846646 no 3165 0.0862380909974756 4371 24099884
SGTC_3035 9091303 49.47 µM -1.36864415343475 0.0582301186551131 no 3166 0.0855552675411416 4480 25237002
SGTC_139 0099-0334 718.624 µM -1.37100447829617 0.0579174842320949 no 3167 0.0851867800065005 4430 97690
SGTC_1879 gemcitabine 100 µM -1.37417360012123 0.0574997982016775 no 3168 0.084693897262907 4376 60750 A nucleoside analog which inhibits DNA replication.
SGTC_263 alizarin 107.927 µM -1.37499773642542 0.0573915672789195 no 3169 0.0845660732337047 4462 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_3216 9129716 49.47 µM -1.39858775772995 0.0543609994083608 no 3170 0.0809683197916475 4356 8056934
SGTC_870 0573-2213 57.6 µM -1.40124567035397 0.0540276292724212 no 3171 0.0805703107542391 4425 3916321
SGTC_2331 7980721 200 µM -1.40523296806384 0.0535305574717935 no 3172 0.0799760068391972 4400 2981221
SGTC_1833 st055984 71 µM -1.40869359653637 0.0531020855091016 no 3173 0.0794628946017265 4451 676288
SGTC_2422 chlorphenesin carbamate 384.24 µM -1.40952915240733 0.0529990411819213 no 3174 0.079339379765565 4401 2724 A muscle relaxant with antifungal properties.
SGTC_2236 dapsone 200 µM -1.40956616545087 0.0529944802453721 no 3175 0.0793339117293383 4459 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1770 st043884 66.3 µM -1.413975789633 0.0524533277506814 no 3176 0.0786845055531548 4454 670149
SGTC_2233 sulbentine 40.3845 µM -1.41534235456752 0.0522865151537248 no 3177 0.0784840711708931 4445 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2832 7992762 51.95 µM -1.41849187542783 0.0519036665132351 no 3178 0.0780236045169776 4387 2985177
SGTC_1945 st075991 56.6 µM -1.42427463285243 0.0512065302391816 no 3179 0.0771834938564556 4429 1084980
SGTC_667 1498-1044 59 µM -1.42812149381539 0.0507469155540517 no 3180 0.0766284459617035 4452 6739982
SGTC_2489 cantharidin 73.42 µM -1.42905982502719 0.0506353056238564 no 3181 0.0764935196406026 4414 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_55 0767-0285 6.563 µM -1.43851833610205 0.0495211486238978 no 3182 0.0751435193368284 4375 3116166
SGTC_755 1995-0008 37.3 µM -1.44091750681136 0.0492416740592054 no 3183 0.0748039947733708 4418 689533
SGTC_2962 9082311 13.18 µM -1.44505091276093 0.0487631373823823 no 3184 0.0742217927227154 4422 16459453
SGTC_556 4058-0063 51.5 µM -1.45136878161945 0.0480388891527373 no 3185 0.0733385989405543 4502 6615692
SGTC_2241 6772625 37.8075 µM -1.45307161348831 0.0478451652037768 no 3186 0.0731019357960166 4271 2285411
SGTC_2112 5488546 200 µM -1.45329320796529 0.0478200013979525 no 3187 0.0730711811540578 4429 600757
SGTC_1238 0333-0287 48.8 µM -1.45579973746682 0.0475361023498378 no 3188 0.0727239941869816 4460 7226
SGTC_250 brefeldin a 552.239 µM -1.45585488397088 0.0475298714599802 no 3189 0.072716369904314 4384 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1481 3346-2004 36 µM -1.46922259081377 0.0460386790640011 no 3190 0.0708862124028698 4552 2770522
SGTC_1297 1068-0111 14.1 µM -1.47100949942397 0.0458422252905886 no 3191 0.0706442739418241 4477 767057
SGTC_1457 k015-0032 57.3 µM -1.47490638757603 0.0454161355538099 no 3192 0.0701188564027195 4470 4302660
SGTC_710 3448-4187 58 µM -1.47587932998523 0.0453102514486443 no 3193 0.0699881446731438 4444 3946412
SGTC_1781 st038725 66.3 µM -1.47901439116209 0.0449704169028054 no 3194 0.0695682342940825 4471 4270275 YIL048W NEO1
SGTC_789 1309-1135 70.6 µM -1.47928029101905 0.0449416885105786 no 3195 0.0695327090763751 4463 3092424
SGTC_203 k066-0004 30.888 µM -1.48116521493075 0.0447384606002136 no 3196 0.0692812765477181 4547 6795412
SGTC_1190 1486-1332 13 µM -1.48484726837147 0.0443436056322645 no 3197 0.068792143632098 4477 4150046
SGTC_2366 9070441 60.58 µM -1.48580416226802 0.0442414516186488 no 3198 0.0686654644472485 4461 6837235
SGTC_2874 9043904 71.43 µM -1.48791528930771 0.0440167473394618 no 3199 0.0683866175166415 4420 4463428
SGTC_550 4123-0385 25.7 µM -1.49072912934737 0.0437186794366654 no 3200 0.0680163125358077 4510 5731123
SGTC_867 0518-0118 155 µM -1.49075728089305 0.0437157056138427 no 3201 0.0680126155934919 4481 6848158
SGTC_2411 st077133 39.94 µM -1.5081418180278 0.0419102089163383 no 3202 0.0657591171974809 4471 1403142 YNL221C POP1
SGTC_2327 6189656 200 µM -1.51225211041818 0.0414922749459913 no 3203 0.0652348694468547 4558 5349088
SGTC_2017 5132927 60.65 µM -1.51379799204448 0.0413359664515961 no 3204 0.0650385410304603 4482 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2434 5670830 169.91 µM -1.51832389307911 0.0408810822037462 no 3205 0.0644663836213893 4513 1549830
SGTC_1167 k781-0610 148 µM -1.52059580322363 0.0406542751928193 no 3206 0.0641806503199852 4532 4525169
SGTC_2992 9074591 71.4286 µM -1.5215498060038 0.0405593411144421 no 3207 0.0640609613018072 4447 17741321
SGTC_2993 9054257 71.4286 µM -1.52410058315557 0.0403063934866146 no 3208 0.0637417935300273 4431 6470217 YGL055W OLE1
SGTC_2652 actinonin 100 µM -1.52625782282238 0.0400934722465711 no 3209 0.0634728340665847 4554 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_447 ml7 120 µM -1.53614860246704 0.0391289159300621 no 3210 0.0622509691858504 4568 4216 Selective myosin light chain kinase inhibitor.
SGTC_677 0929-0063 136 µM -1.53634732765354 0.0391097313990989 no 3211 0.0622266088687034 4548 1539583
SGTC_497 capsazepine 133 µM -1.53863978534841 0.0388889752893847 no 3212 0.0619461300252928 4465 2733484 A calcium channel blocker.
SGTC_3187 9109394 49.47 µM -1.55334091858388 0.037497313792088 no 3213 0.060170854774146 4523 17098090
SGTC_380 3970-0968 6 µM -1.56544518553884 0.0363822479572855 no 3214 0.0587392802665786 4428 2891601
SGTC_3097 9117246 49.47 µM -1.57046551999877 0.035927798381521 no 3215 0.0581534249610231 4554 16423892
SGTC_1816 st051957 91.6 µM -1.57116343050625 0.0358649920301175 no 3216 0.0580723460151432 4541 674121
SGTC_2658 polymyxin b sulfate 77.05 µM -1.57430616480832 0.0355832847375358 no 3217 0.0577083426188313 4560 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_92 0063-0024 660.874 µM -1.57495941251595 0.0355249574474044 no 3218 0.0576329066894317 4619 3594437
SGTC_849 0386-0493 241 µM -1.581966662279 0.0349042095575103 no 3219 0.0568285906219835 4564 726119
SGTC_361 000s-0510 1.45 µM -1.59458774354527 0.0338086228798978 no 3220 0.0554022275929695 4444 660
SGTC_2515 chrysin 20.77 µM -1.5992285824655 0.0334129516709025 no 3221 0.0548849107954701 4544 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1721 st082152 9.2685 µM -1.5994658338391 0.0333928268366563 no 3222 0.0548585671799212 4489 5296051
SGTC_2727 riluzole 51.77 µM -1.60681307532134 0.0327745212870616 no 3223 0.0540476895490326 4593 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2161 5662504 8.5105 µM -1.61034108280603 0.0324809942213592 no 3224 0.0536617075556534 4542 2859334
SGTC_1674 st016616 23.6 µM -1.61088577186519 0.0324358704239362 no 3225 0.0536023108491632 4511 625830
SGTC_1197 1601-0112 267 µM -1.61363685225614 0.0322087516696835 no 3226 0.0533031092218624 4523 7350313
SGTC_1952 st077036 64.1 µM -1.61391952493839 0.0321854898358105 no 3227 0.0532724414882471 4569 2937007
SGTC_547 1120-0019 610 nM -1.61537122702343 0.0320662440725781 no 3228 0.0531151636736111 4539 3676939
SGTC_1949 st076024 69.1 µM -1.62803310389412 0.0310415613623679 no 3229 0.0517589333154341 4522 2921930
SGTC_3008 9078912 71.4286 µM -1.62991074260871 0.0308919426450416 no 3230 0.0515601814359847 4573 16648731
SGTC_13 0199-0087 65 µM -1.63333616152487 0.0306205276320161 no 3231 0.0511991576702328 4659 4589825
SGTC_1792 st045773 43.6 µM -1.64870298004522 0.0294271203190867 no 3232 0.0496042496754568 4549 2919270
SGTC_1478 0453-0656 35.7 µM -1.66089500062202 0.0285079747744704 no 3233 0.0483672682583273 4614 5258496
SGTC_1126 isoteolin 1.0172 µM -1.66672592977823 0.028076901783529 no 3234 0.0477844572391805 4522 133323
SGTC_2853 9015042 58.44 µM -1.66701521231655 0.0280556575931535 no 3235 0.0477556900183176 4500 6457456
SGTC_885 0865-0106 16.8 µM -1.66746760525682 0.0280224618154533 no 3236 0.0477107303574109 4538 2793380
SGTC_1629 st005085 44.9 µM -1.66813034717922 0.0279738900729866 no 3237 0.0476449270274764 4537 24207091
SGTC_370 0180-0345 38.7 µM -1.68118737045884 0.0270311627388476 no 3238 0.0463632629302296 4433 3989527
SGTC_2146 5545642 200 µM -1.68283476137328 0.0269141256976684 no 3239 0.0462035418393529 4535 825326
SGTC_1402 3909-7673 35.9 µM -1.68827918447647 0.026530337990444 no 3240 0.0456788245263644 4605 5328014
SGTC_473 2-arachidonoylglycerol 10 µM -1.68951603707121 0.0264437902329557 no 3241 0.0455602906001442 4443 5282280 An endocannabinoid.
SGTC_970 1315-0089 19.5 µM -1.70024025818136 0.0257032180358065 no 3242 0.044542871312398 4573 6811083 YLR033W RSC58
SGTC_2024 5144227 134 µM -1.70201041807434 0.0255826629520959 no 3243 0.0443767076596656 4562 3475211
SGTC_796 1234-0020 70.7 µM -1.70562905552875 0.025337691779832 no 3244 0.0440385830492259 4557 46495034
SGTC_1192 1488-0095 21.4 µM -1.70837450889885 0.0251531463494775 no 3245 0.0437834370242862 4618 915875
SGTC_269 exalamide 29 µM -1.71137507811212 0.0249527421145507 no 3246 0.0435059473920656 4582 3316 A derivative of salicylamide.
SGTC_1821 st053465 65.6 µM -1.71484259998489 0.0247228199222704 no 3247 0.0431870444023783 4614 675086
SGTC_1789 tunicamycin 25 nM -1.7194519098156 0.0244199426222209 no 3248 0.0427660585376303 4512 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3078 9116413 49.47 µM -1.72119604523598 0.0243061508898205 no 3249 0.0426076276160865 4551 17177322
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.72368838999929 0.0241443171017131 no 3250 0.0423820560222811 4647 279621
SGTC_1366 1683-0113 21.9 µM -1.72443701065073 0.0240958845351088 no 3251 0.042314490502037 4608 708623
SGTC_1752 st044819 83.042 µM -1.73033563554885 0.0237171165289782 no 3252 0.0417851631132247 4544 441209 YML126C ERG13
SGTC_3050 9093513 49.47 µM -1.73441858772143 0.0234578805307883 no 3253 0.0414219196867787 4559 25236664
SGTC_836 0330-0104 1.35 µM -1.73518371665932 0.0234095669326183 no 3254 0.0413541348608949 4639 46494820
SGTC_125 0133-0007 11.75 µM -1.74195074021327 0.022985901175059 no 3255 0.0407585320983695 4684 26541
SGTC_1633 st005664 67.9 µM -1.74285574674161 0.0229297337094297 no 3256 0.040679407867328 4585 2063822
SGTC_833 3852-0053 558 µM -1.74808545418501 0.0226074218362139 no 3257 0.0402246156688826 4646 3123681
SGTC_126 0417-1624 672.48 µM -1.75757796220088 0.0220321453218091 no 3258 0.0394096729024523 4642 41912 YDL195W SEC31
SGTC_2344 7990960 76.95 µM -1.76358636219594 0.0216744417114648 no 3259 0.0389008227290241 4594 140813
SGTC_902 1120-0002 2.07 µM -1.7636292577773 0.0216719057153053 no 3260 0.0388972092391297 4589 3280475
SGTC_765 1319-0117 244 µM -1.81865754818792 0.0186185621858618 no 3261 0.0344818460661626 4597 3487746 YGL099W LSG1
SGTC_615 k087-0205 167 µM -1.81994615135377 0.0185516918382039 no 3262 0.0343836028590227 4646 9642773
SGTC_982 1491-0518 27.5 µM -1.8221686506385 0.0184368386692805 no 3263 0.0342146998633196 4614 3091256
SGTC_2725 haloperidol 53.21 µM -1.82303596325956 0.0183921826992535 no 3264 0.0341489720979465 4611 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2961 9083290 32.55 µM -1.82394594559887 0.018345428834624 no 3265 0.0340801223125259 4609 17741490
SGTC_1934 st074720 32.6 µM -1.82859490181444 0.0181081476043026 no 3266 0.0337301585046264 4578 17250992
SGTC_3326 9140064 16.379 µM -1.82904596937817 0.0180852651119645 no 3267 0.0336963610149146 4598 1868434
SGTC_1571 st070080 73.4 µM -1.83293485653906 0.0178890036699966 no 3268 0.033406129677023 4620 4315245
SGTC_3001 9076041 71.4286 µM -1.84388213676646 0.0173462516941024 no 3269 0.0326001594739847 4636 16004211
SGTC_776 4476-4378 112 µM -1.85394114110423 0.0168600003603227 no 3270 0.0318737905794082 4672 2892008
SGTC_2268 7933382 153.85 µM -1.85400962555657 0.0168567301948521 no 3271 0.0318688914581566 4665 935025 YOR257W CDC31
SGTC_1963 st076565 50.3 µM -1.85483364980245 0.0168174251518372 no 3272 0.0318099926011536 4665 4914280
SGTC_1205 4161-2785 76 µM -1.86411456844008 0.0163801218816745 no 3273 0.0311528085500491 4627 3498106
SGTC_1218 1348-1416 30.7 µM -1.87497575496866 0.0158807579081944 no 3274 0.0303980295285817 4636 6787668
SGTC_3332 9141069 11.198 µM -1.87511866058791 0.0158742755322271 no 3275 0.0303882004532841 4590 17332883
SGTC_924 2046-0044 21.3 µM -1.88640821978199 0.0153692863356368 no 3276 0.0296199828777138 4633 3623589
SGTC_2326 6164455 177.58 µM -1.90353746681519 0.0146294464339307 no 3277 0.0284852248256954 4578 2888790
SGTC_1992 st073643 23.3 µM -1.91286524803193 0.0142396052537387 no 3278 0.0278826527501728 4663 3161292
SGTC_1505 k297-0037 20.6 µM -1.92218498447592 0.0138590705483127 no 3279 0.0272912427612299 4651 4089396
SGTC_1931 st074438 57.1 µM -1.92583401759471 0.0137124835142541 no 3280 0.0270625512007348 4667 2787313
SGTC_2405 ticlatone 3.52 µM -1.93975642961302 0.0131654212249876 no 3281 0.0262046490334117 4491 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_332 4112-0506 40.9 µM -1.94598160834256 0.0129269780025108 no 3282 0.0258284744447373 4671 2790355
SGTC_2473 5854593 8.94 µM -1.94685481852426 0.0128938318722299 no 3283 0.0257760713363773 4658 2872951
SGTC_3158 9100007 49.47 µM -1.95636369247919 0.0125376171822484 no 3284 0.0252111630191056 4679 19297233
SGTC_1925 st057770 10.1 µM -1.97965565049898 0.0117008621967752 no 3285 0.0238711175748901 4660 5989122
SGTC_66 0109-0187 42.4 µM -1.97968300067851 0.0116999088635793 no 3286 0.0238695799495482 4514 759417
SGTC_2459 5811157 9.22 µM -1.98373996077844 0.0115592418370121 no 3287 0.0236424181570053 4642 2870684 YBR192W RIM2
SGTC_990 3985-0011 41.3 µM -1.98915314508442 0.0113738390543577 no 3288 0.0233421509089973 4662 5399565 YGL099W LSG1
SGTC_1164 k060-0068 93.7 µM -2.01352756790329 0.0105706671426601 no 3289 0.0220295788894045 4691 5963676
SGTC_144 4161-2749 112.381 µM -2.01497120109625 0.0105246870954767 no 3290 0.0219538333386708 4702 797501 YMR168C CEP3
SGTC_414 piperonyl butoxide 100 µM -2.03139808073088 0.0100136370218361 no 3291 0.0211073144851392 4703 5794 A potent inhibitor of cytochrome P450.
SGTC_1637 st007924 17.4 µM -2.04427763011965 0.00962822815961901 no 3292 0.0204630639313985 4640 683336
SGTC_2346 9031566 143.75 µM -2.04646463442247 0.00956408799547835 no 3293 0.0203553392684146 4687 4771086
SGTC_818 4072-2707 53.5 µM -2.05010108232648 0.00945826544085853 no 3294 0.0201772839059285 4648 882871
SGTC_331 k048-0133 24.5 µM -2.0643755068777 0.00905270761167337 no 3295 0.0194910634574873 4698 6813582
SGTC_2142 5622915 118.518 µM -2.06849248337092 0.00893860421755779 no 3296 0.0192968683504162 4709 5322196
SGTC_931 2812-0076 566 µM -2.09013205172364 0.00835933904955024 no 3297 0.0183029695969505 4658 3450959
SGTC_1526 st051518 75 µM -2.095697958217 0.00821578276338919 no 3298 0.0180544965532991 4678 673993
SGTC_2734 clemastine 41.6 µM -2.13678960722041 0.00722132960277946 no 3299 0.0163075539077423 4768 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1933 st074711 15.9 µM -2.13931021904215 0.00716393941828 no 3300 0.0162052763129603 4710 17250958
SGTC_1129 3453-1384 223 µM -2.14024399005136 0.00714278133734516 no 3301 0.0161675269045525 4673 1084452
SGTC_461 N-acetylfarnesylcysteine 136 µM -2.15121996920451 0.00689818101860923 no 3302 0.0157294207930295 4738 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1459 k035-0031 35.7 µM -2.15470953160452 0.00682198088536245 no 3303 0.0155922857270102 4547 3877128 YMR208W ERG12
SGTC_981 1488-1094 54.9 µM -2.15866722295699 0.00673645909550924 no 3304 0.0154379967043707 4689 3449522
SGTC_2377 9073351 62.6 µM -2.16007962493362 0.00670616866065038 no 3305 0.015383253018101 4697 7337946 YHR072W ERG7
SGTC_2267 7931562 200 µM -2.19022231376072 0.00608779797962343 no 3306 0.0142540588604127 4696 934880
SGTC_1943 st076331 65.2 µM -2.24441958989408 0.00510199499714426 no 3307 0.0124027086236804 4711 24208415
SGTC_3002 9075603 71.4286 µM -2.27036110874827 0.00468253791415906 no 3308 0.011592841069516 4700 20105405
SGTC_711 k292-0785 179 µM -2.273954357993 0.00462693113308527 no 3309 0.0114843654462029 4686 4146315
SGTC_1303 1160-0052 261 µM -2.2751667544812 0.00460830227279733 no 3310 0.0114479641964098 4700 3562476
SGTC_2195 6536160 144.242 µM -2.35570766445686 0.00351109938892078 no 3311 0.00924373018480051 4767 3834386
SGTC_1349 flufenamic acid 69 µM -2.35795709301986 0.00348414699827853 no 3312 0.00918790838406553 4710 3371 A non-steroidal anti-inflammatory.
SGTC_1504 k297-0033 30 µM -2.36520363984018 0.00339857873545273 no 3313 0.00901007965307936 4700 4388117
SGTC_74 000s-0487 160.283 µM -2.36666911532959 0.0033815055229427 no 3314 0.00897448592510779 4676 677548
SGTC_1290 0986-0249 10.2 µM -2.37702329402684 0.00326305656451195 no 3315 0.00872649296072567 4686 53329
SGTC_3283 9109332 35.8195 µM -2.38882379799363 0.00313262244126487 no 3316 0.00845120331065057 4653 17027281
SGTC_900 1112-0045 141 µM -2.40573023880963 0.00295392553575489 no 3317 0.00807008898819363 4720 56211 YIL048W NEO1
SGTC_2614 arthonioic acid 13.39 µM -2.41520017465963 0.00285789495029101 no 3318 0.00786328206973165 4663 6710684
SGTC_3005 9076496 71.4286 µM -2.41713068919399 0.00283866740784796 no 3319 0.00782169969615758 4739 21368410
SGTC_3210 9128157 49.47 µM -2.41965266309285 0.0028137248494004 no 3320 0.0077676690844608 4686 17590849
SGTC_2733 amorolfine 100 µM -2.43372878947024 0.00267810704906642 no 3321 0.00747209386242695 4802 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2296 7971656 126.45 µM -2.47509585338365 0.00231303227681965 no 3322 0.00666002105579571 4740 666570
SGTC_2352 9027995 87.8 µM -2.48563274023955 0.00222754873039396 no 3323 0.00646606740979453 4732 2997347
SGTC_750 4073-0104 132 µM -2.50825975300353 0.00205357904456135 no 3324 0.00606637208097145 4543 22330957
SGTC_2401 5128683 200 µM -2.52207975581253 0.00195348362368384 no 3325 0.0058331626943912 4733 708373
SGTC_1193 1488-0126 41.5 µM -2.59169642742738 0.00151345547708296 no 3326 0.00477520018377124 4762 1384710
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -2.62358294620334 0.00134385671988968 no 3327 0.00435051278369529 4760 229346 A bile salt which induces apoptosis.
SGTC_1681 tripelennamine 100 µM -2.64061773622129 0.00126054647082758 no 3328 0.00413775166243424 4726 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_613 3914-0030 117 µM -2.69009060258364 0.00104465625666832 no 3329 0.00357163111578771 4660 1145395
SGTC_2357 9067248 200 µM -2.73780113353706 0.000869107289227101 yes 3330 0.00309257324802757 4740 9150235
SGTC_2732 terfenadine 20 µM -2.75048459268439 0.000827238354614094 yes 3331 0.00297535949629228 4803 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2539 epi(13)torulosol 80 µM -2.80362505506881 0.000671224236478337 yes 3332 0.0025265815774566 4759 6708597
SGTC_2464 5717415 7.67 µM -2.81412532992645 0.000643808579790624 yes 3333 0.0024455077728983 4770 5285744
SGTC_2274 7947094 46.08 µM -2.84164151335956 0.000576793246112175 yes 3334 0.00224409639765904 4767 2971028
SGTC_825 1988-2224 89.6 µM -2.97454704859337 0.000334809875535853 yes 3335 0.00146710727869994 4787 1180859
SGTC_167 3672-0051 66.205 µM -2.98276552036938 0.000323506579877369 yes 3336 0.00142828374711973 4762 3237971
SGTC_2298 7976326 193.81 µM -3.0478938988987 0.000245705729342188 yes 3337 0.00115225639517703 4787 2235818
SGTC_1947 st076332 61.6 µM -3.15002198522549 0.000157952102270911 yes 3338 0.000816290882554389 4769 24208416
SGTC_2354 9060492 162 µM -3.17612133385987 0.000140797055314642 yes 3339 0.00074629254427853 4780 6471895
SGTC_2400 5203494 178.7 µM -3.18726812578352 0.000134016160018082 yes 3340 0.000718117826683533 4759 6777674
SGTC_1107 amlodipine 47 µM -3.20801902700456 0.000122200811031439 yes 3341 0.000668263279764237 4517 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_141 0443-0274 32.331 µM -3.22516198389589 0.000113184361645924 yes 3342 0.000629507055789896 4774 1627241
SGTC_1128 3448-9350 235 µM -3.22728151276144 0.000112114004133331 yes 3343 0.00062486220637516 4774 619386
SGTC_160 3453-0671 289.699 µM -3.37385594664686 5.73389223956764e-05 yes 3344 0.00037061573142627 4774 5322268
SGTC_2406 ethylparaben 405.7 µM -3.74362834823298 9.38474241966221e-06 yes 3345 9.06909416675562e-05 4785 8434 A possible steroid mimic.
SGTC_412 gemfibrozil 100 µM -3.76843899995341 8.26110422406866e-06 yes 3346 8.21358083112187e-05 4802 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_633 0437-0093 97.7 µM -3.9151538096897 3.82569111846519e-06 yes 3347 4.51732969086846e-05 4803 2831118
SGTC_630 4356-0227 183 µM -3.95573829285519 3.07726515998983e-06 yes 3348 3.81493258277916e-05 4802 779312
SGTC_1926 methyl fluorone black 53.6 µM -4.0058829514215 2.34483660392767e-06 yes 3349 3.08931208334139e-05 4747 72721 Reacts with homocysteine.
SGTC_926 2268-1401 59.4 µM -4.0081419570901 2.31612595791147e-06 yes 3350 3.05991661643242e-05 4804 2931578
SGTC_2293 7624732 200 µM -4.20807471783833 7.58965883734294e-07 yes 3351 1.28777855677059e-05 4795 894453
SGTC_614 0462-0418 107 µM -4.5482759713492 1.01296860387519e-07 yes 3352 2.70435895727001e-06 4753 5188303
SGTC_166 k072-0058 166.424 µM -4.6865654719467 4.28505901678739e-08 yes 3353 1.38913984230367e-06 4793 5846229
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -4.76432453626761 2.61369462741553e-08 yes 3354 9.47436605358597e-07 4803 4330530
SGTC_2165 5727197 32.143 µM -6.30449139291224 3.00338477438849e-13 yes 3355 1.44570895069467e-10 4808 1361712
SGTC_652 0437-0092 114 µM -6.35944901578342 1.89269797793413e-13 yes 3356 1.01239360738384e-10 4810 3091274