SGTCid condition conc unit DOP1|YDR141C.score DOP1|YDR141C.strain.pval DOP1|YDR141C.strain.significant DOP1|YDR141C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_3037 9091026 49.47 µM 12.7392758534124 1.90179223922681e-35 yes 1 1.78849731611592e-37 2 25236398 YIL048W NEO1
SGTC_429 1112-0049 25.5 µM 7.53838693263369 1.27234878934417e-13 yes 2 2.37910137234202e-14 1 2836170
SGTC_221 trifluoperazine 10.304 µM 6.37564314479105 3.07054072375232e-10 yes 3 9.10983608033524e-11 14 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_206 4546-0025 72.014 µM 5.11884013545766 3.42419596041397e-07 yes 4 1.53710201166456e-07 8 6620745 YIL048W NEO1
SGTC_2406 ethylparaben 405.7 µM 5.06639723979989 4.44685417274265e-07 yes 5 2.0270772174545e-07 4 8434 A possible steroid mimic.
SGTC_286 k060-0067 22.9 µM 5.06232121603218 4.53762254310898e-07 yes 6 2.07091205731655e-07 1 5985051
SGTC_1265 0819-1001 68.8 µM 4.90577793598695 9.74721073129994e-07 yes 7 4.65288812716864e-07 6 3106768
SGTC_1865 st057639 52.2 µM 4.64839459724261 3.2641687826919e-06 yes 8 1.67264244875635e-06 2 688818
SGTC_1800 st050079 29.0735 µM 4.50872573257937 6.13296735768361e-06 yes 9 3.26090770001132e-06 18 3645560
SGTC_3076 9116187 49.47 µM 4.47471206281395 7.13199114668131e-06 yes 10 3.82571766616943e-06 5 27241210
SGTC_2887 9044784 58.44 µM 4.35261720123933 1.21542316941124e-05 yes 11 6.72609579300918e-06 16 6465546
SGTC_2790 5423970 71.43 µM 4.33156495981171 1.33062375597232e-05 yes 12 7.40266263769573e-06 14 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1171 0368-0077 21.4 µM 4.27331670453502 1.70593807116645e-05 yes 13 9.62933039129123e-06 8 3239779
SGTC_2981 9013952 38.96 µM 4.06714195931868 4.0108812321986e-05 yes 14 2.37966262364602e-05 7 2996344
SGTC_427 1354-0053 47.3 µM 4.01434566674365 4.96184120287684e-05 yes 15 2.98054664407521e-05 2 6813657
SGTC_1293 1000-1278 195 µM 3.97585402653601 5.78528597423349e-05 yes 16 3.50635666151891e-05 5 678847
SGTC_1685 st024049 53.0905 µM 3.96955012336483 5.93185483501204e-05 yes 17 3.60042292951828e-05 1 1941139
SGTC_1776 st049249 45.9 µM 3.92320176361117 7.12201978173166e-05 yes 18 4.36899571707599e-05 5 1822314
SGTC_710 3448-4187 58 µM 3.91110758359157 7.46771181217923e-05 yes 19 4.59369170611186e-05 9 3946412
SGTC_291 SEC14.278 35.5 µM 3.67634945748552 0.000182593869537988 yes 20 0.000118297684298679 8 1068044
SGTC_593 1203-0218 61.7 µM 3.57897425898126 0.000260783152949637 yes 21 0.000172472719014051 4 3666956
SGTC_3173 9105693 49.47 µM 3.56481667266573 0.000274460604306883 yes 22 0.000182055299815563 5 17096658
SGTC_3031 9088762 49.47 µM 3.51623434289902 0.000326643045811398 yes 23 0.000218857227122751 8 205253
SGTC_1433 4060-0023 7.6 µM 3.48644714382811 0.000363054260961796 yes 24 0.00024474105039167 5 3840627
SGTC_2069 5228469 200 µM 3.46613195250789 0.000390012357649392 yes 25 0.000264002039913755 6 2835210
SGTC_1614 st002383 48.6 µM 3.45769606144777 0.000401743414178889 yes 26 0.00027240782668882 4 1947235
SGTC_1734 st037168 69.4 µM 3.44680301278648 0.000417375960207414 yes 27 0.000283631016311172 9 708907
SGTC_986 1493-0483 84 µM 3.33390945541042 0.000616109076434631 yes 28 0.000428172644901362 9 40079
SGTC_2572 astragaloside iv 100 µM 3.29524150445409 0.000702201805238969 yes 29 0.0004916856435114 14 45006101 An anti-inflammatory agent.
SGTC_504 lovastatin 124 µM 3.28296394599943 0.000731775864259849 yes 30 0.000513609011992172 10 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1164 k060-0068 93.7 µM 3.2551619589878 0.000803035722600734 yes 31 0.000566638592897749 8 5963676
SGTC_3011 9081274 71.4286 µM 3.25436660297204 0.000805165264108336 yes 32 0.000568227595126654 10 6625322
SGTC_2282 7944268 200 µM 3.24020369746719 0.000843967004356016 yes 33 0.000597221694888408 12 2970414
SGTC_2268 7933382 153.85 µM 3.22835046027086 0.000877755337002197 yes 34 0.000622531681055748 11 935025 YOR257W CDC31
SGTC_2411 st077133 39.94 µM 3.22407629775549 0.000890241091165223 yes 35 0.00063189861389474 30 1403142 YNL221C POP1
SGTC_3306 9127676 59.7925 µM 3.20077119818375 0.000961239299188393 yes 36 0.000685301600427297 7 41905287
SGTC_2283 7944793 200 µM 3.17421483629805 0.00104845847370465 no 37 0.000751212205931208 16 2970533
SGTC_1327 1436-0082 2.18 µM 3.16078900136463 0.00109526261270594 no 38 0.000786712153354949 19 15992205
SGTC_181 1447-1644 8.07 µM 3.11561807632388 0.00126714757649262 no 39 0.000917799217459087 23 534600
SGTC_2663 amphotericin b 100 µM 3.11406217177023 0.00127348547045817 no 40 0.000922653009227444 16 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3217 9129673 49.47 µM 3.01849088718664 0.00172314325539467 no 41 0.00127018520893609 30 17248312
SGTC_387 norethindrone acetate 66.7 µM 3.00235881980162 0.00181194988105065 no 42 0.00133948101079836 11 541197
SGTC_1369 1866-0067 208 µM 2.99765878789694 0.00183859541923852 no 43 0.00136031044296581 17 3531355
SGTC_731 3966-0296 387 µM 2.9806412871665 0.00193807839518475 no 44 0.00143822756984606 9 660956
SGTC_1140 3229-1848 2.98 µM 2.97997611869352 0.00194206440020866 no 45 0.00144135428187092 13 2849525
SGTC_172 1112-0046 2.638 µM 2.95380742930161 0.00210491353695292 no 46 0.00156939900381648 15 2802135 YIL048W NEO1
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 2.93671449328562 0.00221787083558383 no 47 0.0016585466895658 8 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3044 9093193 49.47 µM 2.92835476527811 0.00227509167824081 no 48 0.00170380494485219 22 25236277
SGTC_2809 7964133 12.99 µM 2.92611086619873 0.00229067674014257 no 49 0.0017161429872605 24 1253665
SGTC_1402 3909-7673 35.9 µM 2.92339164314047 0.00230969273213572 no 50 0.00173120356104366 12 5328014
SGTC_2544 sphondin 68.51 µM 2.90980432148466 0.00240687007630241 no 51 0.00180827553551854 59 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_270 tamoxifen 5.46 µM 2.89186515445581 0.00254083621645221 no 52 0.00191481138071183 21 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2024 5144227 134 µM 2.87627777539399 0.00266267326259568 no 53 0.0020119771296123 18 3475211
SGTC_420 mitomycin C 81.9 mM 2.83662511453957 0.00299674483067526 no 54 0.00227965554639322 21 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1463 k081-0032 34.1 µM 2.81029269752458 0.00323899303113888 no 55 0.00247482317608585 7 977755
SGTC_1897 st060201 15 µM 2.80626517956273 0.0032775592015308 no 56 0.00250597137418525 19 611878
SGTC_1728 st035614 33.7865 µM 2.78938336395936 0.00344374622288218 no 57 0.00264042569744768 23 15945546
SGTC_2366 9070441 60.58 µM 2.78723145784426 0.00346546508613301 no 58 0.0026580247128708 19 6837235
SGTC_2591 skatole 100 µM 2.77104116960453 0.00363285609616951 no 59 0.00279386806836313 25 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_3152 9099253 49.47 µM 2.77034042599786 0.00364026218441999 no 60 0.00279988657957261 46 25236131
SGTC_1303 1160-0052 261 µM 2.7638042887582 0.00370999721075783 no 61 0.00285658975619699 8 3562476
SGTC_718 1130-0073 349 µM 2.73843988355124 0.00399209955602302 no 62 0.00308657226807506 17 6740020
SGTC_3025 9087895 49.47 µM 2.7286754146796 0.00410572167686834 no 63 0.00317946300396079 16 17173641
SGTC_489 paxilline 115 µM 2.72026509568749 0.00420589714055469 no 64 0.00326147995882904 14 105008 A toxic potassium channel blocker.
SGTC_1985 st071382 65.5 µM 2.71785774933953 0.00423497071717152 no 65 0.00328530401468083 17 6123237
SGTC_3045 9092950 49.47 µM 2.70527675306639 0.00438985527468 no 66 0.00341237522049941 12 44120432
SGTC_1357 1503-1303 39.5 µM 2.68605956184424 0.00463621745008035 no 67 0.00361500995418829 33 292895
SGTC_166 k072-0058 166.424 µM 2.67579808039988 0.00477275869188599 no 68 0.00372757727385713 29 5846229
SGTC_1656 st012921 11 µM 2.67267356983642 0.00481504029703742 no 69 0.00376247174075794 19 6732821
SGTC_1998 st075797 76.8 µM 2.66643035184692 0.00490052650912274 no 70 0.00383307445666642 14 24208315
SGTC_75 0159-0059 199.013 µM 2.66385449608785 0.00493618914403002 no 71 0.00386254844654873 31 5377270
SGTC_2447 5741742 33.78 µM 2.64837870202181 0.00515535991761716 no 72 0.00404394337943531 30 1776504
SGTC_984 1492-0255 2.91 µM 2.6269003683313 0.00547388250279088 no 73 0.00430832795774091 16 1585198
SGTC_1220 1838-0075 193 µM 2.61860863169061 0.00560145279287477 no 74 0.00441445877269288 12 5529645
SGTC_342 k048-0088 23.3 µM 2.61614013028796 0.0056399379183658 no 75 0.00444650261871179 39 6820570
SGTC_2083 5306046 65.942 µM 2.6147578130709 0.00566159130386771 no 76 0.0044645372123604 20 539837
SGTC_2550 chrysin dimethyl ether 71.87 µM 2.61295219537335 0.00568998666445237 no 77 0.00448819284597693 6 88881 An O-methylated flavonoid and antioxidant.
SGTC_2199 6590217 200 µM 2.61185772445117 0.00570725992350273 no 78 0.00450258608047439 15 703109
SGTC_1871 st057448 67.3 µM 2.59956736991943 0.00590444980098219 no 79 0.00466706773084897 30 691747
SGTC_1243 0416-0003 5.65 µM 2.58189528328571 0.00619857415268055 no 80 0.00491296971917315 33 2141977
SGTC_124 0136-0217 7.121 µM 2.57351516103547 0.00634252994560293 no 81 0.00503356180499537 55 3976905
SGTC_1987 st072290 61.9 µM 2.5354676217251 0.00703399575254703 no 82 0.00561486545520085 23 54697379
SGTC_2106 5357045 167.29 µM 2.50909819993599 0.00755147044916526 no 83 0.00605199151357351 21 668842
SGTC_1238 0333-0287 48.8 µM 2.48700112180254 0.00801062956094126 no 84 0.00644124964026369 17 7226
SGTC_2050 5263056 171 µM 2.48257458556256 0.00810550536672055 no 85 0.00652183790356325 60 763468 YGL055W OLE1
SGTC_799 1310-0557 151 µM 2.48116124642896 0.0081360053447317 no 86 0.00654775591329579 28 5354492
SGTC_313 3474-0040 5.03 µM 2.47876855783402 0.00818786969079437 no 87 0.00659184104981267 39 1043375 YIL048W NEO1
SGTC_1350 1495-0454 146 µM 2.46033735566417 0.00859721770506503 no 88 0.00694032354799201 24 1069057
SGTC_2347 9049783 174.81 µM 2.4557205667368 0.00870252428422308 no 89 0.00703012197536314 27 6467988 YPL169C MEX67
SGTC_967 1306-0166 352 µM 2.44766277351198 0.00888902998529291 no 90 0.0071893080827536 21 4437607
SGTC_2997 9067075 71.4286 µM 2.44259199086695 0.00900818580994194 no 91 0.00729110637167193 53 27209819
SGTC_2873 9040596 71.43 µM 2.43642608373171 0.0091549584802903 no 92 0.00741660033870834 46 6463863
SGTC_1139 k015-0024 46.9 µM 2.42924441754012 0.00932854577641746 no 93 0.00756516422165514 23 2766652
SGTC_2157 5649910 96.377 µM 2.41852575322281 0.00959298086338245 no 94 0.00779177120829515 36 2858091
SGTC_1568 digitonin 820 nM 2.40983781809211 0.00981210132175055 no 95 0.00797980663408968 58 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_11 0438-0307 1.3 µM 2.39169271541392 0.0102838845672647 no 96 0.00838543843780436 33 4011476
SGTC_52 0329-0193 875 nM 2.3889203347209 0.0103576832710563 no 97 0.00844898303773479 29 3739292
SGTC_3101 9120531 49.47 µM 2.37885297910344 0.0106295648177866 no 98 0.00868330048240535 34 24824904
SGTC_266 formosanin C 406 nM 2.36747621405575 0.0109442708159064 no 99 0.00895493561614956 53 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1159 4092-0538 61.2 µM 2.3618834801502 0.0111019286126924 no 100 0.00909117800614766 34 717301
SGTC_943 3253-1379 105 µM 2.35667931833365 0.0112504029807822 no 101 0.00921958131913546 34 668464
SGTC_447 ml7 120 µM 2.35578972738399 0.0112759549416691 no 102 0.00924168850711257 16 4216 Selective myosin light chain kinase inhibitor.
SGTC_557 1315-0110 16.2 µM 2.35010929834418 0.0114403078830777 no 103 0.00938394957911437 29 6833801
SGTC_2445 5742597 35.57 µM 2.34428885197293 0.0116108666545841 no 104 0.00953170056319032 37 1774255
SGTC_1392 3455-1037 33.9 µM 2.3332452618767 0.011940556661181 no 105 0.00981763826591761 34 981132
SGTC_1161 k007-0610 110 µM 2.31530986352857 0.0124932983797668 no 106 0.0102979901734347 69 5843850
SGTC_141 0443-0274 32.331 µM 2.31036773192575 0.0126494476900468 no 107 0.01043390198846 31 1627241
SGTC_881 0833-0569 170 µM 2.29259562947566 0.0132250056707229 no 108 0.0109356481201837 39 5418700
SGTC_1765 st044815 90.4 µM 2.2914652909738 0.0132623655559562 no 109 0.0109682585543609 49 645695
SGTC_1298 1079-1278 263 µM 2.28968142963018 0.0133215111186162 no 110 0.011019895347222 32 2840950
SGTC_1194 1488-0194 225 µM 2.28649838177237 0.0134276140449381 no 111 0.0111125593436523 21 1391452
SGTC_1066 ketoconazole 628 nM 2.28060998320534 0.0136258208394367 no 112 0.0112857680137303 31 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1494 4358-1428 177 µM 2.26938631761535 0.0140106153053681 no 113 0.0116224217517102 26 1564571
SGTC_3127 9126946 49.47 µM 2.26665022849225 0.0141058276985088 no 114 0.0117058005590443 41 27243249
SGTC_2116 5511452 16.8835 µM 2.26194595219905 0.0142708341695004 no 115 0.0118503713911432 38 870744
SGTC_1837 st055472 66.5 µM 2.25412475478669 0.0145488495561824 no 116 0.0120941603743863 21 676091
SGTC_2212 7123476 200 µM 2.2486931636826 0.014744654619105 no 117 0.0122660122141014 7 1085715
SGTC_15 0266-0086 27.098 µM 2.24815336434739 0.0147642372686096 no 118 0.0122832061266227 51 1712902 YIL048W NEO1
SGTC_541 4513-1321 94 µM 2.22993562854939 0.0154383780957576 no 119 0.0128758583327935 52 747515
SGTC_439 amiodarone 34.4 µM 2.2206084894699 0.0157936386485267 no 120 0.0131887451544991 37 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2916 7875993 68.79 µM 2.21328756376936 0.0160773747932193 no 121 0.0134389132299303 43 1299250
SGTC_1560 lithocholic acid 53.1 µM 2.18866167061076 0.0170640786553052 no 122 0.0143107199103158 22 9903 A bile acid which acts as a detergent.
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 2.18580842040428 0.0171816799336817 no 123 0.0144148122331609 33 7104
SGTC_3096 9117468 49.47 µM 2.18291654873992 0.0173015790121225 no 124 0.0145209780578053 23 41316311
SGTC_2269 7935389 174.42 µM 2.18141070289546 0.0173642949389645 no 125 0.0145765263526363 41 97605
SGTC_2764 methyldopa 94.69 µM 2.16694288987862 0.0179768117773169 no 126 0.0151196045231333 32 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 2.16489600449834 0.0180649401023744 no 127 0.0151978251337277 25 2724278 An inhibitor of dopamine biosynthesis.
SGTC_66 0109-0187 42.4 µM 2.16474003383157 0.018071670470388 no 128 0.0152037996963782 38 759417
SGTC_161 4065-0411 162.148 µM 2.16310325082742 0.018142429123302 no 129 0.0152666195681152 52 1906281 YLR208W SEC13
SGTC_522 1273-0010 11.6 µM 2.15527526323613 0.0184841094699444 no 130 0.0155701501703213 47 5705015
SGTC_274 sirtinol 40.1 µM 2.15370646428298 0.0185532404530933 no 131 0.0156315994434226 59 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_295 k015-0027 31 µM 2.15266742470959 0.0185991480446807 no 132 0.0156724126899997 29 3887424
SGTC_372 0155-0182 15.9 µM 2.14930895211528 0.0187481964989906 no 133 0.0158049586750892 30 771486
SGTC_1394 3474-0001 65.7 µM 2.14866570541812 0.018776859364779 no 134 0.0158304545475839 24 5017666 YIL048W NEO1
SGTC_2400 5203494 178.7 µM 2.14517159416415 0.0189332080619872 no 135 0.0159695649375049 63 6777674
SGTC_2196 6573537 42.6665 µM 2.14408194550703 0.0189821918071871 no 136 0.0160131607126043 40 2903087
SGTC_2028 5153890 36.43 µM 2.13893924734196 0.0192148323986895 no 137 0.0162202944702511 55 2830968 YPR165W RHO1
SGTC_2864 9034755 47.6 µM 2.12996571453931 0.0196265733389294 no 138 0.0165872220230014 34 4930451
SGTC_1442 4112-3290 3 µM 2.12950970165341 0.0196476955209202 no 139 0.0166060565402912 26 704353
SGTC_2034 5197015 53.07 µM 2.11966604188138 0.02010837363099 no 140 0.0170171093471628 46 780676
SGTC_903 1134-0042 114 µM 2.11715874762869 0.0202271669376748 no 141 0.0171231885813202 42 701009
SGTC_1346 1488-2224 62.4 µM 2.11478478135819 0.0203401911591276 no 142 0.0172241472686145 59 3722427
SGTC_1947 st076332 61.6 µM 2.11476746367412 0.0203410176145521 no 143 0.017224885609706 35 24208416
SGTC_3263 9137018 49.47 µM 2.10762260521966 0.020684430288552 no 144 0.0175318233305332 56 43844957
SGTC_2508 celastrol 40.54 µM 2.10630631827066 0.0207482293934958 no 145 0.0175888764199721 30 122724 Celastrol is a natural product and antioxidant.
SGTC_1124 fisetin 1.16336 µM 2.10569116914441 0.0207781021390573 no 146 0.0176155937090495 45 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1162 k048-0130 20.1 µM 2.10558895543036 0.0207830693470746 no 147 0.0176200364312174 51 6797406
SGTC_2589 lobaric acid 100 µM 2.10400438950161 0.0208602020843476 no 148 0.0176890320561809 36 73157 A novel microtubule depolymerizer.
SGTC_1256 0570-0116 285 µM 2.10310820871697 0.0209039331304089 no 149 0.0177281557862815 52 410638
SGTC_43 0570-0105 72.5 µM 2.0997055423517 0.0210706807991749 no 150 0.0178773758739829 57 1114046 YDL195W SEC31
SGTC_2342 7990637 118.86 µM 2.09529201062777 0.0212886413426534 no 151 0.0180725211252602 64 2033102 YER133W GLC7
SGTC_475 α-linolenic acid 10 µM 2.07786265876315 0.0221681065353413 no 152 0.018861005336764 57 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2388 9080168 200 µM 2.07785032128802 0.0221687397680936 no 153 0.0188615736736422 40 15943073
SGTC_1804 st050076 49.1 µM 2.07629962691761 0.0222484522702531 no 154 0.018933123899694 46 3895976
SGTC_412 gemfibrozil 100 µM 2.04608905510311 0.0238503108118392 no 155 0.0203738048160958 52 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_660 4031-1742 102 µM 2.0401306224837 0.0241774311307095 no 156 0.0206686587215577 65 6738706
SGTC_2323 6148992 148.28 µM 2.03929378248968 0.0242236743934459 no 157 0.0207103579034906 49 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_47 0149-0135 24.25 µM 2.03752140060496 0.0243218604312246 no 158 0.0207989097966577 50 5239155
SGTC_3057 9095946 49.47 µM 2.03333167808445 0.0245552911058998 no 159 0.0210095123983929 45 24540043
SGTC_1604 st002052 72.4 µM 2.03203902919405 0.0246276895538967 no 160 0.0210748524768424 39 6254834 YHR062C RPP1
SGTC_438 sphingosine 6.67 µM 2.02832472127599 0.0248367172541679 no 161 0.021263558747722 29 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2174 5790901 200 µM 2.02718353379134 0.0249012371595366 no 162 0.0213218232418211 62 786020
SGTC_1063 disulfiram 1.84 µM 2.02252631112067 0.0251660039703486 no 163 0.0215610041242539 58 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1547 harmine 94.2 µM 2.01188641215731 0.025779752387071 no 164 0.0221159560323104 71 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_108 0509-0257 621.132 µM 2.01151398421144 0.0258014603371434 no 165 0.0221355973663633 65 536624
SGTC_764 1951-2361 146 µM 1.99651066331896 0.0266887745376087 no 166 0.0229391831210478 70 5438930
SGTC_765 1319-0117 244 µM 1.99513643217686 0.0267713072611671 no 167 0.0230140009019253 46 3487746 YGL099W LSG1
SGTC_491 tetrandrine 80.3 µM 1.99167429375101 0.0269801794887964 no 168 0.0232034029891132 45 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1772 st048439 82.2 µM 1.98643512378521 0.0272988461852468 no 169 0.0234925149127106 53 2927068 YDL195W SEC31
SGTC_465 cgp-37157 41 µM 1.98606184601309 0.0273216696977759 no 170 0.023513228560611 30 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1724 st037281 8.293 µM 1.98273300192949 0.0275259115749613 no 171 0.0236986306005132 60 574124 YDL195W SEC31
SGTC_793 0488-0545 106 µM 1.98054781518901 0.0276606749434615 no 172 0.0238210030505497 52 292548
SGTC_2996 9066192 71.4286 µM 1.9771158060064 0.027873441258968 no 173 0.0240142707683671 53 6472854
SGTC_2626 ethyl orsellinate 100 µM 1.97705454196391 0.027877251654929 no 174 0.0240177326825319 77 75653 A natural product.
SGTC_78 0336-0123 156.75 µM 1.97433107667637 0.0280470800084457 no 175 0.0241720547362821 47 6765896
SGTC_2226 7298446 200 µM 1.96829131452841 0.0284267795129901 no 176 0.0245172643640329 39 3283010
SGTC_2982 9019404 25.97 µM 1.96738490961861 0.0284841295520723 no 177 0.0245694263647386 48 22333232
SGTC_2414 st077232 92.9 µM 1.96459368640281 0.0286613407072912 no 178 0.0247306416495106 50 729801
SGTC_1485 3909-9022 254 µM 1.96218883768367 0.0288147558285552 no 179 0.0248702515081871 38 714516
SGTC_1471 k673-0312 37 µM 1.95005966550168 0.0295989657249774 no 180 0.0255845039804495 43 24099884
SGTC_2231 micatex 6.853 µM 1.94918019341352 0.0296565100729726 no 181 0.0256369547207964 53 20737 An antifungal of unknown mechanism.
SGTC_69 0096-0274 206.684 µM 1.94891259897507 0.0296740373363377 no 182 0.0256529316074372 120 6741392
SGTC_1704 st028805 70.8 µM 1.94881339795779 0.0296805371226849 no 183 0.02565885658111 61 2876101
SGTC_289 k017-0060 526 µM 1.93498374742361 0.0305983069768583 no 184 0.026496145061469 44 5512909
SGTC_3234 9132280 49.47 µM 1.93415218231579 0.0306542326623927 no 185 0.0265472098166967 54 17612295
SGTC_1041 0206-0046 107 µM 1.91808998508004 0.0317511845477207 no 186 0.0275498010644039 58 50494
SGTC_2345 9052315 157.45 µM 1.91644885590324 0.0318650675504248 no 187 0.0276539936069443 55 6469265
SGTC_3292 9120825 59.784 µM 1.91155970896499 0.0322063418361545 no 188 0.0279663456953201 60 24824900
SGTC_2119 5528445 120.635 µM 1.91007019909772 0.032310910825207 no 189 0.0280620877087847 55 791935
SGTC_390 dec-rvkr-cmk 16.7 µM 1.90996106070333 0.0323185837401288 no 190 0.0280691135739658 67 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1203 3992-3522 103 µM 1.90597968606344 0.0325995216918471 no 191 0.0283264206354253 72 5322312
SGTC_1731 st035964 63 µM 1.89924995142684 0.0330789702554487 no 192 0.0287658099442882 78 6739575
SGTC_3132 9126706 49.47 µM 1.89907396954626 0.0330915853226737 no 193 0.0287773755357013 64 850858
SGTC_1766 st045414 44.774 µM 1.89456692544074 0.0334160208826635 no 194 0.0290749000341415 66 253960
SGTC_1462 k081-0014 26.5 µM 1.88549653832564 0.0340768849385581 no 195 0.0296814156851831 37 3270634
SGTC_2067 5224629 34.075 µM 1.88330929786045 0.0342378442414936 no 196 0.0298292320556236 61 2835000
SGTC_2126 5251174 33.877 µM 1.87968440192411 0.034505976536533 no 197 0.0300755513204609 61 790722
SGTC_3 0833-0587 95.581 µM 1.87834868664727 0.0346052128755822 no 198 0.030166740138772 77 5382644
SGTC_1927 st060202 13.8 µM 1.87761061820697 0.0346601477992241 no 199 0.0302172260491284 52 688887
SGTC_126 0417-1624 672.48 µM 1.8751937059913 0.0348405416634802 no 200 0.0303830398709917 93 41912 YDL195W SEC31
SGTC_1206 3978-0017 132 µM 1.87327186446951 0.0349845338876962 no 201 0.0305154265091511 72 3873677
SGTC_1441 4106-0040 13 µM 1.86466801734575 0.035635169139649 no 202 0.0311139762067947 59 2904180
SGTC_2567 aureobasidin a 60 nM 1.85986114462607 0.036002969253839 no 203 0.031452586933073 128 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1565 sinapyl alcohol 95.1 µM 1.85865207427548 0.036095969616232 no 204 0.0315382353793769 50 5280507 A phenol propionate derived from cinnamic acid.
SGTC_324 1315-0088 19.6 µM 1.85794497481047 0.0361504500381837 no 205 0.0315884143565092 67 6787421
SGTC_1945 st075991 56.6 µM 1.85549794332077 0.0363395082112679 no 206 0.0317625763252722 75 1084980
SGTC_2192 5915882 198.485 µM 1.84378913920168 0.037255364452053 no 207 0.0326069380689305 72 2876149
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.84341879036761 0.0372846378320319 no 208 0.0326339443385531 65 6708514
SGTC_1324 1418-0026 34.4 µM 1.81921179415329 0.0392391594298689 no 209 0.0344395620817025 50 1372513
SGTC_3305 9127027 53.8275 µM 1.81824869365469 0.0393186149742358 no 210 0.0345130653206249 62 41905295
SGTC_973 1325-0077 65.9 µM 1.81650167939383 0.0394630773034818 no 211 0.0346467252787123 54 2835149
SGTC_1383 3049-0032 20.7 µM 1.81289655476871 0.0397625534931538 no 212 0.0349238888619385 78 712864
SGTC_786 4544-0069 423 µM 1.80641034790921 0.040306011121388 no 213 0.0354271332067379 75 748821 YLR208W SEC13
SGTC_2885 9057732 51.95 µM 1.80126821303417 0.0407411271770863 no 214 0.035830307715556 66 6471414
SGTC_3169 9102970 49.47 µM 1.79100994613517 0.0416205445912125 no 215 0.0366458494661921 47 17027839
SGTC_2299 7976368 114.88 µM 1.78945171319361 0.04175546378471 no 216 0.0367710486834337 64 2979718
SGTC_1038 k292-0204 154 µM 1.78760527139857 0.0419157957719554 no 217 0.0369198572076705 65 4454212
SGTC_1712 st032288 53.4 µM 1.78757373717839 0.0419185383041788 no 218 0.0369224028847564 107 2883011
SGTC_3290 9121031 71.43 µM 1.78745907789741 0.0419285114503273 no 219 0.0369316602453126 58 17014854
SGTC_1673 st016611 27.3 µM 1.78260282380062 0.0423526786259152 no 220 0.03732548992278 79 5226799
SGTC_932 2857-0803 154 µM 1.77825157512878 0.0427356786684183 no 221 0.037681272855813 69 674898
SGTC_2173 5763948 167 µM 1.76926880565708 0.0435352042147531 no 222 0.0384245132919797 66 2867177
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.76491163542876 0.0439273464349984 no 223 0.0387893089360447 59 6312947
SGTC_2000 st075254 36.4 µM 1.76422711487184 0.043989210936774 no 224 0.0388468746786602 56 17234175
SGTC_433 pimozide 108 µM 1.75966769155195 0.0444030698059361 no 225 0.0392320834279769 52 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_762 1165-0429 115 µM 1.75810375196706 0.04454574918841 no 226 0.039364928752886 68 5967793
SGTC_440 fluspirilene 35.1 µM 1.7556079888735 0.0447742042812309 no 227 0.0395776835986849 66 3396 An atypical antipsychotic.
SGTC_2002 4023503 131 µM 1.7514215000559 0.0451595414147431 no 228 0.039936666110264 89 4736863 YCR052W RSC6
SGTC_2670 beta-carotene 100 µM 1.75031169721955 0.0452621372465849 no 229 0.0400322717970312 33 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1681 tripelennamine 100 µM 1.74946219396363 0.0453407962904069 no 230 0.0401055791664403 58 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1230 0170-0365 3.77 µM 1.74935851257857 0.045350404106022 no 231 0.0401145337521169 91 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2162 5663267 200 µM 1.74858455384339 0.0454221760849184 no 232 0.0401814290958714 82 6456493
SGTC_2257 7960413 200 µM 1.73657102191849 0.0465479914878721 no 233 0.0412314590748303 81 2974689 YIL048W NEO1
SGTC_3295 9122362 53.5725 µM 1.7269947116247 0.0474613581359125 no 234 0.0420843066223938 83 4730473
SGTC_343 4130-2827 29.8 µM 1.71692665182996 0.0484370531415929 no 235 0.0429962872674308 65 1118244
SGTC_2746 daunorubicin 9.88 µM 1.7120493538365 0.0489154455608062 no 236 0.0434437867980601 37 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_278 4092-0821 23.9 µM 1.71066229455134 0.0490521833378956 no 237 0.0435717360102943 54 877900
SGTC_356 1634-0012 32.5 µM 1.70910106648106 0.0492064559298538 no 238 0.0437161150406205 90 735457
SGTC_2698 st077697 67.5 µM 1.70316225587978 0.0497968422377634 no 239 0.0442688539798739 66 3154499
SGTC_1652 st011932 78 µM 1.70092235426541 0.0500209764634777 no 240 0.0444787841770261 92 1551076
SGTC_2200 6600604 21.907 µM 1.69827972934008 0.0502864424962149 no 241 0.0447274893517684 82 2904777
SGTC_3216 9129716 49.47 µM 1.69824281124289 0.0502901590570688 no 242 0.0447309717376789 66 8056934
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.69696319853442 0.0504191135748022 no 243 0.0448518091997253 105 6708760
SGTC_2381 9035592 200 µM 1.69307832522847 0.0508122311531106 no 244 0.0452202796813432 69 4749657
SGTC_35 0133-0054 64.071 µM 1.68781928155578 0.0513482873668761 no 245 0.0457229625578066 94 99677
SGTC_2688 kanamycin b 96.69 µM 1.68180690626854 0.051966631648383 no 246 0.0463031445461386 120 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_3233 9132340 49.47 µM 1.67976760405636 0.0521777028482883 no 247 0.0465012702822393 102 17682950
SGTC_1105 epirubicin 18.1 µM 1.67879523265459 0.052278584371897 no 248 0.0465959790262322 86 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2339 9000433 200 µM 1.67804671784463 0.0523563466911001 no 249 0.0466689895808121 70 2988954
SGTC_214 4373-3496 70 µM 1.67721143189107 0.0524432319570382 no 250 0.0467505721795687 119 3779166
SGTC_2769 toremifene 3.73 µM 1.67603598279166 0.0525656943441884 no 251 0.046865572349827 79 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_638 3970-0837 4.09 µM 1.67568110844576 0.0526027109627541 no 252 0.0469003360698686 62 4118451 YLR208W SEC13
SGTC_685 1278-0033 54.9 µM 1.67478791724895 0.052695970483347 no 253 0.0469879251955739 84 3590572
SGTC_1719 st032227 49.2 µM 1.66684673804348 0.053530901248582 no 254 0.0477724419753124 83 3125804
SGTC_1622 st003707 19.4 µM 1.66620295478547 0.053599044939276 no 255 0.0478364988322864 78 10140899
SGTC_2485 5633444 17.78 µM 1.66497334916315 0.0537293881817182 no 256 0.0479590364905645 77 5724239
SGTC_1665 st014639 11.4 µM 1.6608530526473 0.0541679873162182 no 257 0.048371481533745 84 981133 YIL048W NEO1
SGTC_334 1502-1024 68.5 µM 1.65796182371889 0.0544774422395783 no 258 0.0486625860834836 56 3296216
SGTC_2064 5220758 200 µM 1.65711546906089 0.0545682936174527 no 259 0.0487480661173015 108 788518
SGTC_1128 3448-9350 235 µM 1.65587884978163 0.0547012530674608 no 260 0.048873177788225 66 619386
SGTC_1468 k284-1086 134 µM 1.65268527626607 0.0550458062557498 no 261 0.0491974662474253 91 15996457
SGTC_2546 rhodinyl acetate 100 µM 1.6506095556382 0.0552706727469537 no 262 0.0494091632134613 87 6708682
SGTC_1983 st071813 46.9 µM 1.64344802645545 0.0560520674969525 no 263 0.0501451351716275 77 11838595
SGTC_3117 9124945 49.47 µM 1.63859440272707 0.0565865816568506 no 264 0.050648879412462 62 17592065
SGTC_2070 5230947 200 µM 1.63713496393796 0.0567480879725303 no 265 0.0508011362027906 79 2835538
SGTC_2902 5787006 60.46 µM 1.6330759432658 0.0571991821975462 no 266 0.0512265127215521 82 591003
SGTC_2304 7443016 91.4 µM 1.62862866372596 0.0576966600200244 no 267 0.0516958262576137 71 939854
SGTC_2587 piperic acid 92.2 µM 1.62780435181731 0.0577892411513613 no 268 0.0517831887466801 68 5370536
SGTC_197 4544-0043 41.561 µM 1.62732053621077 0.0578436344137566 no 269 0.0518345192706396 102 896523
SGTC_3019 9081971 49.47 µM 1.62725182465123 0.0578513626152482 no 270 0.0518418125169489 79 16451803
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.62700748452673 0.0578788508797728 no 271 0.0518677541004558 66 521171
SGTC_2201 6605497 169.863 µM 1.62675774452923 0.0579069572390271 no 272 0.0518942796477385 70 670741
SGTC_2642 cholecalciferol 100 µM 1.62546957094864 0.0580521019153055 no 273 0.0520312712232964 55 9821465 A vitamin D precursor, similar to steriods.
SGTC_2939 9044578 71.43 µM 1.62186269885182 0.0584600266456942 no 274 0.052416374949042 76 2653634
SGTC_616 4092-0450 108 µM 1.61957816707773 0.058719561408486 no 275 0.0526614613558196 75 787165
SGTC_2813 7971799 71.43 µM 1.61396485411464 0.0593611043711316 no 276 0.053267524935302 93 2234054
SGTC_642 0335-0876 158 µM 1.60807572725612 0.0600400634671473 no 277 0.0539092972610888 88 6812350
SGTC_1935 st074532 41.6 µM 1.60313840809472 0.0606139617040553 no 278 0.0544520499834855 85 2829742
SGTC_2415 st077333 57.7 µM 1.6027143081278 0.0606634571824841 no 279 0.0544988715641656 123 2766255
SGTC_1645 Cervolide 78 µM 1.5987935826592 0.0611225320196238 no 280 0.0549332377197467 88 23173 A fragrance.
SGTC_2658 polymyxin b sulfate 77.05 µM 1.59538212553421 0.0615241820778768 no 281 0.0553134053167715 90 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1123 mangostin 811.285 nM 1.59537698626845 0.0615247887037843 no 282 0.0553139795921309 44 5281650 An antioxidant.
SGTC_422 cantharidin 155 µM 1.59472633212941 0.0616016280099682 no 283 0.0553867234751915 91 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2041 5107442 45.335 µM 1.59010647090342 0.0621493695979948 no 284 0.0559054038164498 113 793005
SGTC_1781 st038725 66.3 µM 1.57865670600825 0.063523257674116 no 285 0.0572074101445269 101 4270275 YIL048W NEO1
SGTC_2104 5389443 200 µM 1.5766214941227 0.0637699236804537 no 286 0.0574413220031531 96 2244536
SGTC_1001 4048-4355 44.4 µM 1.5764210287704 0.0637942601694588 no 287 0.0574644026219149 103 21824233
SGTC_2934 9036370 36.88 µM 1.57637971595055 0.0637992764425084 no 288 0.0574691600883247 77 6462800
SGTC_483 fpl-64176 144 µM 1.57236810971849 0.0642878354807441 no 289 0.0579326028316742 69 3423
SGTC_824 1304-0008 100 µM 1.56683899425897 0.064965965846287 no 290 0.0585761651110726 96 768245
SGTC_1893 st059353 36.1 µM 1.56461546733242 0.0652402354892077 no 291 0.0588365499808941 101 3112488
SGTC_2365 9042475 200 µM 1.56427774595505 0.0652819715279125 no 292 0.0588761779876414 85 6464479
SGTC_613 3914-0030 117 µM 1.56024937224864 0.0657814015976414 no 293 0.0593504811752696 47 1145395
SGTC_3054 9094397 49.47 µM 1.55610755424312 0.0662979789516182 no 294 0.0598412594898186 95 2598354
SGTC_251 melphalan 456.522 µM 1.5505248282428 0.0669992339509495 no 295 0.0605077995033244 111 460612 A DNA alkylator.
SGTC_1695 st026914 34.495 µM 1.54909275739536 0.0671800399724088 no 296 0.0606797118544081 80 3289191
SGTC_1667 st014849 34.6 µM 1.54142577266884 0.0681544582807964 no 297 0.0616065977419401 85 5348460
SGTC_3355 9151058 44.0485 µM 1.5410638959005 0.0682007184070248 no 298 0.0616506178878007 88 17015728
SGTC_2377 9073351 62.6 µM 1.54030654452608 0.0682976120331086 no 299 0.0617428246378182 109 7337946 YHR072W ERG7
SGTC_2355 9061122 103.12 µM 1.53816960716419 0.0685715791771996 no 300 0.0620035750680642 90 5302957
SGTC_3068 9116768 49.47 µM 1.53800821240073 0.0685923052542516 no 301 0.0620233034051295 102 41904888
SGTC_2205 7238770 200 µM 1.53518168820243 0.0689560671064744 no 302 0.0623696025342353 80 279867
SGTC_2504 purpurogallin 52.29 µM 1.52669749179894 0.0700568804810662 no 303 0.0634181257041359 85 5281571 An antioxidant.
SGTC_1534 6-azauridine 81.6 µM 1.52591110272905 0.0701595941984312 no 304 0.0635160026237418 109 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_797 k781-0471 270 µM 1.52219388834872 0.0706466843503829 no 305 0.0639802530266174 99 23738129
SGTC_2097 5376186 200 µM 1.51231667138317 0.0719535858714466 no 306 0.0652266609534559 97 742755
SGTC_735 3076-0345 636 µM 1.51066686899932 0.072173674391386 no 307 0.065436673803422 92 2888990
SGTC_1036 k216-0215 33.5 µM 1.50947317896372 0.0723332376373906 no 308 0.0655889522092426 80 622330
SGTC_2467 5474540 200 µM 1.50535083064953 0.0728863603682229 no 309 0.0661169516110115 103 5413519
SGTC_3280 9140961 49.47 µM 1.50518834257978 0.0729082286115199 no 310 0.0661378306927944 92 4901226
SGTC_3281 9140613 49.47 µM 1.50395268936668 0.0730746917299557 no 311 0.0662967744410627 81 16013766
SGTC_1959 st077091 55.8 µM 1.50294081307792 0.0732112248452207 no 312 0.0664271536311778 130 821356 YKL052C ASK1
SGTC_173 1273-0061 2.693 µM 1.49862144517529 0.0737962354967991 no 313 0.0669859330486472 127 2847414 YPL266W DIM1
SGTC_409 arachidonic acid 100 µM 1.49852991422846 0.0738086708977215 no 314 0.066997813259534 97 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1359 1582-0056 520 nM 1.49805138014442 0.0738737106481763 no 315 0.0670599508723078 87 3661189
SGTC_577 r071-0003 38.6 µM 1.49794206244481 0.0738885746591773 no 316 0.067074152018754 104 4568517 YMR134W ERG29
SGTC_2181 6316240 54.2555 µM 1.49233488706543 0.0746540556363889 no 317 0.067805687650778 73 12779990
SGTC_2254 7938975 95.19 µM 1.49083507041472 0.0748598301655583 no 318 0.0680024008554085 93 2969277
SGTC_2452 5863136 48.41 µM 1.48825278896125 0.0752151320883206 no 319 0.068342120199315 86 2184096
SGTC_89 0302-0250 142.109 µM 1.4856896680229 0.0755690676599964 no 320 0.0686806123801476 107 4203518 YLR208W SEC13
SGTC_2433 5607874 27.82 µM 1.47850361578077 0.0765681396596935 no 321 0.0696365150051045 81 2252428
SGTC_1309 pyrazolanthrone 13.4 µM 1.47604590316518 0.0769121295711803 no 322 0.0699657849027976 105 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2468 5987765 72.9 µM 1.47546909161877 0.0769930320509681 no 323 0.0700432360199852 94 26772094
SGTC_384 k007-0144 5.16 µM 1.47431105087667 0.0771556518822334 no 324 0.070198930560175 112 6824886
SGTC_1932 st074806 40.9 µM 1.47133452272274 0.0775748333089635 no 325 0.0706003357112459 119 17251235
SGTC_3034 9090421 49.47 µM 1.47075975237363 0.0776559764542612 no 326 0.0706780502388651 65 17173761
SGTC_2743 auranofin 4.32 µM 1.47046883485321 0.0776970712584483 no 327 0.0707174101597677 74 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2529 gangaleoidin 93.61 µM 1.46923301895387 0.0778718257781972 no 328 0.0708847986408847 78 4565183
SGTC_1970 st070122 35.8 µM 1.46907893792575 0.0778936349983583 no 329 0.0709056898915756 128 102928
SGTC_2685 mycophenolic acid 18.85 µM 1.46839646686552 0.077990290308402 no 330 0.0709982803775946 80 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1840 st055363 71 µM 1.46658119580599 0.0782478219053044 no 331 0.0712450092299177 86 676033
SGTC_2666 tannic acid 100 µM 1.46621390240256 0.07830000799698 no 332 0.0712950111586981 121 16134267 A thiamine antagonist.
SGTC_3279 9140807 49.47 µM 1.4600830920459 0.079174992641071 no 333 0.0721336194370871 93 45595718
SGTC_404 fumagillin 50 µM 1.45585553752937 0.0797826452625416 no 334 0.0727162795502225 108 12015870 A methionine aminopeptidase binder.
SGTC_2974 9094440 9.66 µM 1.44899750910932 0.0807758852520361 no 335 0.0736691390995786 115 25236134
SGTC_1415 3966-0071 78.1 µM 1.44799130359968 0.0809223948068293 no 336 0.073809741366752 101 2893185
SGTC_503 tyrphostin 8 294 µM 1.44763608999396 0.0809741639172732 no 337 0.0738594261411996 115 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_263 alizarin 107.927 µM 1.4475911837468 0.0809807103685947 no 338 0.0738657091298432 141 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_717 1532-0246 73.2 µM 1.44698159390492 0.0810696161512294 no 339 0.0739510393675907 101 9561992
SGTC_560 2332-1943 155 µM 1.44621983637491 0.0811808183833927 no 340 0.0740577758463762 99 21177716
SGTC_2389 9091542 195.52 µM 1.44183355248343 0.0818233735235617 no 341 0.0746746675226289 126 3626624 YOL127W RPL25
SGTC_1980 st071811 45.7 µM 1.44087647487873 0.0819640857406433 no 342 0.0748097916543224 113 4974850
SGTC_1062 mesoridazine 14.2 µM 1.43776795848453 0.0824223664031518 no 343 0.0752499517542632 101 4078 A neuroleptic.
SGTC_1023 4482-3888 16 µM 1.42885586618899 0.0837469465494418 no 344 0.0765228322977207 121 3303168
SGTC_150 3970-0969 77.2 µM 1.42834471217587 0.0838234000641792 no 345 0.0765963321227258 150 6615640
SGTC_918 glabranin 770.725 nM 1.42799771781248 0.0838753300174252 no 346 0.0766462577028093 102 124049 Also referred to as licorice root.
SGTC_3013 9080133 71.4286 µM 1.42646851582987 0.0841044728894895 no 347 0.0768665743201077 98 17050193
SGTC_1037 k284-1091 78.7 µM 1.42552980469129 0.0842453664151504 no 348 0.0770020554689152 102 3334711
SGTC_2523 spermine 47.74 µM 1.4236445947532 0.0845288573427413 no 349 0.0772746898791615 79 1103 A DNA binding polyamine.
SGTC_157 1348-1695 65.819 µM 1.42274135724133 0.084664936182986 no 350 0.0774055734194479 138 5380510
SGTC_3089 9117425 49.47 µM 1.42171555481947 0.0848196794331659 no 351 0.0775544213310219 87 9401657
SGTC_1778 st046819 58.9 µM 1.42098350965384 0.0849302387250511 no 352 0.0776607767460002 126 671715
SGTC_2130 NSC 7 2.4545 µM 1.41266936931043 0.0861934969060207 no 353 0.0788764809607918 105 21448
SGTC_582 0987-0078 156 µM 1.41147989830498 0.0863753694977167 no 354 0.0790515793594081 110 1625765
SGTC_2436 5633522 8.09 µM 1.40691891910844 0.0870754129126771 no 355 0.0797257164239437 112 5724242
SGTC_722 3534-0461 190 µM 1.40634947354933 0.0871631111547551 no 356 0.0798101879732446 87 658262
SGTC_1846 st056244 14.8 µM 1.40594363123733 0.0872256536978656 no 357 0.0798704319200986 88 5393182
SGTC_1250 0485-0349 40.2 µM 1.40350415117216 0.0876022972540304 no 358 0.080233277487795 101 6842794 YDL195W SEC31
SGTC_2182 6325192 200 µM 1.40238335664275 0.0877757486447835 no 359 0.0804004003164848 107 736248
SGTC_167 3672-0051 66.205 µM 1.40142280907859 0.087924604361366 no 360 0.0805438377416062 116 3237971
SGTC_1425 4048-4433 7.33 µM 1.39966847221976 0.088196959095586 no 361 0.0808063095686193 132 23734946
SGTC_2705 st078069 42.8 µM 1.39939268823987 0.0882398307422137 no 362 0.0808476291463631 102 1530061
SGTC_2080 5212524 12.4 µM 1.39885883555044 0.0883228642631817 no 363 0.0809276594187381 119 260183
SGTC_26 0302-0163 425.158 µM 1.39826443726366 0.0884153833215663 no 364 0.0810168364729383 143 3100915
SGTC_2552 juarezic acid 87.02 µM 1.39685882983669 0.0886344556628854 no 365 0.0812280135704579 91 1549512
SGTC_2185 6113692 200 µM 1.39489418549809 0.0889413343846486 no 366 0.0815238753892019 111 874150
SGTC_992 3909-8734 162 µM 1.39431713073431 0.0890316208210058 no 367 0.0816109300479043 106 4288319
SGTC_1754 st042065 16.137 µM 1.39160025589817 0.0894576220040315 no 368 0.0820217406708101 131 1126236 YIL048W NEO1
SGTC_2434 5670830 169.91 µM 1.38830880233848 0.0899757447642404 no 369 0.0825215164961821 117 1549830
SGTC_501 nsc-95397 161 µM 1.38767965925455 0.0900750344073547 no 370 0.0826173062953662 123 262093
SGTC_3328 9140624 29.0385 µM 1.3864462337644 0.0902699264496349 no 371 0.0828053435762025 109 4904392
SGTC_1307 1187-1599 12.2 µM 1.3851248919214 0.0904790573326125 no 372 0.0830071408841503 133 1538471
SGTC_1718 roemerine 11.9335 µM 1.38295942558338 0.0908225666332945 no 373 0.0833386536482477 125 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3246 9135460 32.98 µM 1.38011112870592 0.0912758660425243 no 374 0.0837762156529224 111 41446951
SGTC_3166 9102297 49.47 µM 1.37923956795934 0.0914149073968462 no 375 0.0839104510600169 108 25237072
SGTC_1796 st049173 110.4 µM 1.37386604300075 0.0922756231217681 no 376 0.0847416366633929 115 94134
SGTC_1618 st003135 44.5 µM 1.36983421439996 0.0929253578294795 no 377 0.0853693295265871 120 1270615
SGTC_1417 3966-0327 90.4 µM 1.36781058658919 0.0932527402465472 no 378 0.085685686538172 107 651118
SGTC_4 0960-0234 25.671 µM 1.36740620229305 0.0933182635614333 no 379 0.0857490096745735 107 6821112
SGTC_1432 4049-0298 68.4 µM 1.3630701149763 0.0940229886146245 no 380 0.0864302071271736 101 741646
SGTC_1716 st033144 30.6155 µM 1.3598410327127 0.0945503426510681 no 381 0.0869401172318194 125 674617
SGTC_744 1594-0068 283 µM 1.35910815387649 0.0946703349855118 no 382 0.0870561597071372 120 668392
SGTC_1727 st034309 9.9045 µM 1.35749150407504 0.0949354216280798 no 383 0.0873125455758301 148 870305
SGTC_1848 st056003 16.4 µM 1.35515774170137 0.0953190591566672 no 384 0.0876836525692158 114 146492
SGTC_140 0062-0056 502.533 µM 1.34938567184957 0.0962728059762963 no 385 0.0886065602920946 105 3758964
SGTC_3253 9135987 49.47 µM 1.3424541384457 0.0974273830180128 no 386 0.0897243954889118 132 4182430
SGTC_1801 st050089 28.441 µM 1.34022924039754 0.0978001262984766 no 387 0.0900854140021561 130 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_3165 9101544 49.47 µM 1.33728555234552 0.0982948955107779 no 388 0.0905647225707543 117 5002184
SGTC_2095 5432005 200 µM 1.33630652534717 0.0984598539798771 no 389 0.0907245522739087 115 783734
SGTC_2453 5731132 22.18 µM 1.33016743692025 0.0994988653503353 no 390 0.0917315552108975 142 1362040
SGTC_572 0960-0087 17.7 µM 1.32916951628999 0.0996685130497898 no 391 0.0918960248706793 168 6796365
SGTC_1239 0337-0584 35.4 µM 1.32915558805088 0.0996708823616403 no 392 0.0918983219611098 154 914301 YML130C ERO1
SGTC_2553 4-methylesculetin 85.09 µM 1.3288268365316 0.0997268177387412 no 393 0.0919525530778834 104 5319502
SGTC_521 r062-0005 13.8 µM 1.32810235709028 0.099850165133714 no 394 0.092072147448983 111 2832033
SGTC_1841 st054148 70 µM 1.31849941795214 0.101495668181458 no 395 0.0936682598850994 126 675442
SGTC_1254 0550-0035 264 µM 1.31767402776297 0.101638018551389 no 396 0.0938063962590647 132 15121435
SGTC_1746 st038117 42 µM 1.31610646013693 0.101908768175238 no 397 0.094069156503648 124 2898218
SGTC_1501 4491-0275 38.4 µM 1.31216838854551 0.102591265228825 no 398 0.0947316626200947 120 5104718
SGTC_2696 st077691 74.316 µM 1.31193488457693 0.102631837297756 no 399 0.0947710529673563 129 757133
SGTC_3350 9150499 3.57 µM 1.31003877779876 0.102961723907968 no 400 0.0950913588227817 129 4910996 YPR165W RHO1
SGTC_401 neomycin 50 µM 1.30909296253891 0.103126565478869 no 401 0.0952514314085962 111 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1872 amphotericin b 148 nM 1.3065164639849 0.103576582983249 no 402 0.095688491933228 109 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2648 atorvastatin 78.68 µM 1.30513935695577 0.103817695431013 no 403 0.0959226996683939 125 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_174 3553-0389 74.3 µM 1.30428851008902 0.103966870319659 no 404 0.0960676156925838 112 738071
SGTC_626 0214-0009 33 µM 1.30275624023941 0.104235907732019 no 405 0.0963289973741981 129 3437874
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.29978542579522 0.104758963130408 no 406 0.0968372609937771 124 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1917 st066507 28.5 µM 1.29392194688796 0.105796886981202 no 407 0.0978461914335761 146 3156428
SGTC_975 1335-0046 28.5 µM 1.29328386078414 0.10591028472285 no 408 0.0979564502495957 125 16486740
SGTC_2976 9009005 19.48 µM 1.29086490358479 0.106340968391838 no 409 0.0983752635941959 95 2993148
SGTC_1885 st057546 99.9 µM 1.28977305820399 0.106535779931489 no 410 0.0985647324226228 117 702008
SGTC_486 niguldipine 82 µM 1.28855474513957 0.106753460337007 no 411 0.0987764624848217 122 1236 A calcium channel blocker.
SGTC_1549 4'-methoxyflavonol 74.6 µM 1.28777961102952 0.106892123317471 no 412 0.0989113458176554 115 97141
SGTC_868 0527-0199 213 µM 1.28465647914784 0.107452133801863 no 413 0.0994561764001525 132 2849450
SGTC_1021 4476-0760 85.3 µM 1.28344297923371 0.107670296590958 no 414 0.0996684622272182 112 746768
SGTC_1216 1165-0504 9.65 µM 1.28331560820177 0.10769321382403 no 415 0.0996907632958926 139 6304004
SGTC_2519 cryptotanshinone 88.04 µM 1.28121767845926 0.108071189577452 no 416 0.100058609163789 144 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1264 0783-0040 158 µM 1.27965151626995 0.108353980848832 no 417 0.10033386159091 112 2855798
SGTC_147 4466-0538 29.23 µM 1.27880288805882 0.108507434134781 no 418 0.100483238327011 131 6742687 YHR072W ERG7
SGTC_7 0192-1582 4.227 µM 1.26989385115101 0.110127854438648 no 419 0.102061221866677 168 252616
SGTC_2156 5649887 115 µM 1.26970396149763 0.11016258045181 no 420 0.102095050580669 140 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2539 epi(13)torulosol 80 µM 1.26716709763965 0.110627262237595 no 421 0.102547773906573 129 6708597
SGTC_693 4161-2696 114 µM 1.26622038527283 0.110801032643685 no 422 0.102717095578198 138 805759
SGTC_457 grayanotoxin iii 135 µM 1.26579574014067 0.110879040366434 no 423 0.102793110305431 149 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_573 3702-0553 84.7 µM 1.2615953240616 0.111652780897747 no 424 0.103547219797572 140 1222756
SGTC_1794 st048918 76.9 µM 1.25822377679737 0.112276627877434 no 425 0.10415541917657 98 672303
SGTC_804 1595-0054 20.9 µM 1.25597689359523 0.112693755832314 no 426 0.104562173857379 136 761523 Stimulates phospholipase C.
SGTC_330 1488-0319 80.1 µM 1.25279773908682 0.113285846366234 no 427 0.105139662341436 148 6846614
SGTC_1377 2944-0135 198 µM 1.25218974147113 0.113399333077716 no 428 0.105250366582602 119 1894137
SGTC_1575 cyproterone acetate 48 µM 1.25178879464329 0.113474216764251 no 429 0.105323417136932 146 9880 An androgen receptor antagonist and liver toxin.
SGTC_2432 5630864 12.22 µM 1.25097153861062 0.113626962502169 no 430 0.105472430762583 128 5714970
SGTC_930 2810-3379 265 µM 1.24968707632094 0.113867325556836 no 431 0.105706940069421 139 1015764
SGTC_91 0417-1751 58.384 µM 1.24929977598515 0.113939872606019 no 432 0.105777724920701 144 6795624
SGTC_470 aa-861 153 µM 1.24862776772216 0.114065827772127 no 433 0.10590062563913 146 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2675 theaflavin digallate 100 µM 1.24714478236142 0.114344136053635 no 434 0.106172207582447 136 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2506 ethyl hematommate 54.16 µM 1.24671111293389 0.114425613037301 no 435 0.106251721285638 113 3940691 An allergen.
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.24628669954286 0.114505391023624 no 436 0.106329579520278 128 5355888
SGTC_2610 ononetin 44.17 µM 1.24178617788441 0.115353801290563 no 437 0.107157731917178 120 259632
SGTC_2847 9005661 71.43 µM 1.24013114023336 0.115666919482043 no 438 0.107463446328282 86 2991449
SGTC_1674 st016616 23.6 µM 1.23803333910032 0.116064671504189 no 439 0.107851849600893 124 625830
SGTC_1510 1123-0200 71.5 µM 1.23088356779376 0.117427588952372 no 440 0.109183207125815 158 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2990 9074105 71.4286 µM 1.22865467739287 0.117854776742237 no 441 0.109600652914312 137 6502001
SGTC_838 0109-0203 71.4 µM 1.22836454865467 0.117910463419174 no 442 0.109655074903394 129 759422
SGTC_1281 0884-0031 11.8 µM 1.22789779557284 0.118000090047019 no 443 0.109742668576331 139 1548255
SGTC_407 eburnamonine 100 µM 1.22730449232846 0.118114086575253 no 444 0.109854083895334 129 3195
SGTC_568 1193-0097 7.48 µM 1.22703514371688 0.118165864571415 no 445 0.109904691157224 158 3646150
SGTC_2865 9030313 51.95 µM 1.22550582810108 0.118460155531118 no 446 0.110192347774587 111 42562754
SGTC_2520 obtusaquinone 4.71 µM 1.22110031562555 0.11931081637997 no 447 0.111024020110797 152 5967872
SGTC_609 0986-0026 86.3 µM 1.22098615628516 0.119332916573518 no 448 0.111045630698591 146 2848610
SGTC_970 1315-0089 19.5 µM 1.22065381517006 0.119397271189088 no 449 0.11110856067652 130 6811083 YLR033W RSC58
SGTC_1458 k015-0034 6.33 µM 1.22030145662127 0.119465528726844 no 450 0.111175308914602 123 3598957
SGTC_1467 k284-1082 293 µM 1.21957612223358 0.119606124359957 no 451 0.111312801353458 142 3334705
SGTC_2740 felodipine 17.08 µM 1.21815456006491 0.119882012149475 no 452 0.111582621823602 89 3333 L-type calcium channel blocker
SGTC_3322 9139058 2.11 µM 1.21781766500316 0.119947460319279 no 453 0.111646634931693 133 4908926 YPR165W RHO1
SGTC_1223 0764-0573 147 µM 1.21776820315308 0.119957071329194 no 454 0.111656035341819 117 1609797
SGTC_3249 9135183 49.47 µM 1.21529438820312 0.120438454893348 no 455 0.112126915746895 137 4902779
SGTC_2335 9018011 154.17 µM 1.21459770783558 0.120574268223597 no 456 0.112259781766494 143 6458208
SGTC_1475 4092-1048 11.7 µM 1.21413091253607 0.12066532725857 no 457 0.112348868636658 144 2881759
SGTC_3213 9129884 49.47 µM 1.21229435608201 0.121024059255803 no 458 0.112699861780445 138 17190742
SGTC_2022 5136654 200 µM 1.21119145497889 0.121239847633086 no 459 0.112911018458824 161 1713771
SGTC_705 1124-0212 310 µM 1.21083440986364 0.121309763323784 no 460 0.112979437246128 163 9554485
SGTC_2328 6201408 200 µM 1.20031551181066 0.123382280161926 no 461 0.115008413825914 157 2890418
SGTC_3029 9088683 49.47 µM 1.19914527414964 0.123614373869344 no 462 0.11523573118987 117 25236615
SGTC_2327 6189656 200 µM 1.19733891473021 0.123973229751345 no 463 0.115587241202351 131 5349088
SGTC_2193 5925765 200 µM 1.1972359909205 0.123993698783976 no 464 0.115607292659917 131 877370
SGTC_926 2268-1401 59.4 µM 1.19405309793747 0.124627866220236 no 465 0.116228599157532 147 2931578
SGTC_1073 triclabendazole 3.09 µM 1.19105725730237 0.125226832889454 no 466 0.116815553977692 147 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_233 rapamycin 362 pM 1.18907797590188 0.125623657022515 no 467 0.117204492074767 146 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_875 0709-0210 25.7 µM 1.18668002992518 0.126105593106042 no 468 0.117676927517918 153 6251364
SGTC_3269 9137823 49.47 µM 1.18437031863318 0.126571013104261 no 469 0.118133252119289 116 17682936
SGTC_3214 9129694 49.47 µM 1.18404218192492 0.126637231461377 no 470 0.118198182755315 161 17158655
SGTC_361 000s-0510 1.45 µM 1.18046364680583 0.127360950408865 no 471 0.118907930425876 139 660
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.18012976434809 0.127428620852121 no 472 0.118974304087809 162 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2808 7946468 45.46 µM 1.17866252904727 0.127726292716431 no 473 0.119266291013911 174 2970879
SGTC_207 4185-0010 4.486 µM 1.1705487591223 0.129381134901366 no 474 0.12089010209863 148 3761753
SGTC_2776 terbinafine 19.92 µM 1.16997147355668 0.129499438641265 no 475 0.121006224423529 139 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1715 st032160 10.2275 µM 1.16695831816795 0.130118144140267 no 476 0.121613601377088 133 5289825
SGTC_1957 st077035 62.4 µM 1.1657738899238 0.130361907619759 no 477 0.121852938230059 146 705593
SGTC_499 genistein 192 µM 1.165435289074 0.130431652028151 no 478 0.121921419920616 129 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1133 3473-0247 50 µM 1.16463558755944 0.130596475583609 no 479 0.122083266078492 170 711311
SGTC_2836 9010338 19.48 µM 1.16322722007906 0.130887099085399 no 480 0.122368662691365 129 2994051
SGTC_2859 9028643 45.46 µM 1.16257797998739 0.131021223342627 no 481 0.122500384585 116 17151580
SGTC_3248 9135562 49.47 µM 1.16251774507614 0.131033671875863 no 482 0.122512610462427 143 17650701
SGTC_3032 9089427 49.47 µM 1.16190365078551 0.131160631174511 no 483 0.122637302014361 127 17173707
SGTC_2785 7756463 72.73 µM 1.1595121220455 0.131655871089116 no 484 0.123123749149152 185 2201551
SGTC_467 ro 31-8220 72.8 µM 1.15828135772631 0.131911241178424 no 485 0.123374618255556 148 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_668 1682-0499 62.6 µM 1.15801423224722 0.131966711879197 no 486 0.123429114229014 142 682214
SGTC_1527 coumarin 137 µM 1.1577911007834 0.132013059208015 no 487 0.123474647955671 163 323 A hepatotoxic, DNA x-linker.
SGTC_2459 5811157 9.22 µM 1.15719784785828 0.132136340210018 no 488 0.123595768413387 142 2870684 YBR192W RIM2
SGTC_2834 9001755 58.44 µM 1.15617908877652 0.132348228723865 no 489 0.123803955671518 151 2989575
SGTC_2765 myclobutanil 7.74 µM 1.15328518264427 0.132951400166383 no 490 0.124396674954192 168 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_676 falcarinol 140 µM 1.15241865988611 0.133132375490665 no 491 0.124574538395855 166 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_3265 9137266 49.47 µM 1.15205860012544 0.133207624660013 no 492 0.124648496927862 110 17224265
SGTC_122 0236-0016 402.397 µM 1.15028072664726 0.133579612837362 no 493 0.125014133170492 170 6808838
SGTC_993 3909-8757 62.7 µM 1.15014190933337 0.133608687909598 no 494 0.125042713743146 130 4288324 YLR208W SEC13
SGTC_1366 1683-0113 21.9 µM 1.14935901956192 0.133772744438489 no 495 0.125203985410631 143 708623
SGTC_1152 3909-8331 15.9 µM 1.1470959921307 0.134247745994226 no 496 0.125670975062802 132 16001939
SGTC_699 0375-0592 111 µM 1.14174175190097 0.135376190773954 no 497 0.126780690226049 124 762578
SGTC_861 0443-0273 110 µM 1.14032854066909 0.135675116532978 no 498 0.127074725797892 158 6149169
SGTC_1493 4348-0038 111 µM 1.13871496424848 0.13601697647886 no 499 0.127411029612192 191 800424
SGTC_2879 9041815 71.43 µM 1.13835993916137 0.136092272852149 no 500 0.127485107431934 109 4942971
SGTC_1019 4262-0212 3.4 µM 1.13592833932418 0.136608751573562 no 501 0.127993278343566 170 4677213
SGTC_2783 7738165 71.43 µM 1.13458158467294 0.136895382119471 no 502 0.12827533630575 155 17201110
SGTC_2825 7998094 58.44 µM 1.1338979121395 0.137041045709046 no 503 0.128418686510357 146 2987815
SGTC_2053 5265679 138 µM 1.13327999585146 0.137172790325223 no 504 0.128548344807323 178 764595
SGTC_867 0518-0118 155 µM 1.13308392545475 0.137214612152996 no 505 0.128589505533391 164 6848158
SGTC_2027 5150920 200 µM 1.13257694752044 0.137322790949679 no 506 0.128695976949042 135 786715
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.13220544673611 0.137402098641204 no 507 0.128774035369936 156 94937 An inhibitor of serotonin biosynthesis.
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.12943173778913 0.137995216216652 no 508 0.129357875318996 166 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1195 1502-0147 41.1 µM 1.12933818161137 0.138015252251027 no 509 0.12937759995397 144 817940
SGTC_585 0kpi-0023 191 µM 1.12708422622275 0.138498560141509 no 510 0.129853435910904 117 64601
SGTC_802 4112-3352 742 µM 1.12692048738966 0.138533714973911 no 511 0.129888050214255 146 704594
SGTC_1889 st059080 5.18 µM 1.12269840918623 0.139442297855625 no 512 0.130782801930137 130 176925 Isolated from Daphnopsis sellowiana.
SGTC_2709 st078560 56 µM 1.12156177919501 0.139687589330056 no 513 0.13102440508445 175 17250903
SGTC_787 4152-0075 138 µM 1.11889702650893 0.140263808312015 no 514 0.13159203583274 152 9566539
SGTC_1080 nisoldipine 24.4 µM 1.11748985133526 0.140568742541298 no 515 0.131892468228133 169 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2702 st077768 96.8 µM 1.11441183461286 0.141237315083763 no 516 0.132551274269778 141 6484119
SGTC_195 4234-0266 16.654 µM 1.11389174115453 0.141350496552048 no 517 0.132662816458026 176 2303354
SGTC_1466 k213-0079 57.5 µM 1.11317410644213 0.14150676737492 no 518 0.132816830590612 186 3657981
SGTC_1916 st067606 49.2 µM 1.11237719292849 0.141680438936201 no 519 0.132988003259712 173 19590279
SGTC_3227 9130768 49.47 µM 1.11208010973386 0.141745219280587 no 520 0.13305185395025 151 17720899
SGTC_1812 st052057 4.327 µM 1.10738936208988 0.14277071734875 no 521 0.134062811619631 153 3645418
SGTC_3331 9141060 1.957 µM 1.10608292943643 0.14305722228452 no 522 0.13434531332039 146 4906567 YPR165W RHO1
SGTC_2726 cimetidine 79.27 µM 1.10587887604274 0.143102006908331 no 523 0.134389474507425 171 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1213 1315-0166 115 µM 1.10542418781887 0.143201833681642 no 524 0.134487913872486 159 768401
SGTC_149 3970-0822 46.1 µM 1.10224052116877 0.143902125053334 no 525 0.135178559927955 168 3114250 YBL034C STU1
SGTC_833 3852-0053 558 µM 1.10176858560284 0.144006130053833 no 526 0.135281145460489 179 3123681
SGTC_1356 1502-0781 85.8 µM 1.09530429139973 0.145435831959889 no 527 0.136691674032273 172 567702
SGTC_1048 3161-0300 24.5 µM 1.09385850553988 0.145756897021381 no 528 0.137008519941672 148 2165101
SGTC_2374 9071832 200 µM 1.09359125128586 0.145816298197004 no 529 0.137067143983355 147 17381698
SGTC_2043 5101342 149 µM 1.09294381599761 0.145960267624661 no 530 0.137209234368156 172 678451
SGTC_2010 4012422 159 µM 1.0926354327442 0.146028876018514 no 531 0.137276949537687 156 952393
SGTC_2331 7980721 200 µM 1.09112830909094 0.146364489063186 no 532 0.137608213896204 179 2981221
SGTC_3252 9135871 49.47 µM 1.08983203756856 0.146653562566506 no 533 0.137893569272767 158 17682838
SGTC_2455 5377712 9.75 µM 1.08765513121618 0.147139882413063 no 534 0.138373691278687 154 2243908
SGTC_821 1114-0266 29.2 µM 1.08403060162825 0.147951996823957 no 535 0.139175615398385 167 3123235
SGTC_1426 4048-4480 71.7 µM 1.08350068653604 0.14807098086098 no 536 0.139293123146585 153 14224343
SGTC_1775 st081588 35.1725 µM 1.08130055609487 0.148565670019289 no 537 0.139781720077745 169 1426443 YGL099W LSG1
SGTC_396 dithiazanine 1.25 µM 1.07626817856432 0.149701326904398 no 538 0.140903667927771 142 10578 An antihelmenthic.
SGTC_682 0kpi-0099 17 µM 1.07607679785758 0.149744629811587 no 539 0.140946455706924 201 1714895 YML126C ERG13
SGTC_1784 st039334 36.3 µM 1.06941095825111 0.151258095649115 no 540 0.142442265832594 187 3496984
SGTC_1088 bifonazole 369 nM 1.06775153178928 0.15163644146242 no 541 0.142816303258322 163 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_120 rhodamine 6G 52.259 µM 1.06451474851638 0.152376230013739 no 542 0.143547788385855 208 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1397 3532-0190 20.1 µM 1.06445853106228 0.152389100019382 no 543 0.143560515349234 130 5322280
SGTC_442 cape 100 µM 1.06074127525177 0.15324170205172 no 544 0.144403748298718 155 5281787
SGTC_1418 3966-3099 2.4 µM 1.05776905161173 0.153925690841759 no 545 0.145080372762813 186 740335
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.05258287419837 0.155124001038406 no 546 0.146266104796872 178 676296 Flavone; oxidizing agent.
SGTC_1847 st056231 15 µM 1.04830727514605 0.156116534044319 no 547 0.147248529417588 173 5393180
SGTC_579 4491-1009 110 µM 1.0458070575796 0.156698866626921 no 548 0.147825061028531 196 1271041
SGTC_1657 st012939 43.4 µM 1.04458237382801 0.156984632112488 no 549 0.148108014763437 147 24207257
SGTC_524 r073-0010 27.8 µM 1.04341712432966 0.157256847386418 no 550 0.148377572940817 181 2772106
SGTC_3187 9109394 49.47 µM 1.04083042513734 0.15786223763714 no 551 0.148977128357656 192 17098090
SGTC_633 0437-0093 97.7 µM 1.03965218943412 0.158138498209318 no 552 0.149250760296555 172 2831118
SGTC_2877 9040724 71.43 µM 1.03949851230312 0.158174554218858 no 553 0.149286474799862 149 6463895
SGTC_3283 9109332 35.8195 µM 1.0383712329941 0.158439203483194 no 554 0.14954862849479 143 17027281
SGTC_878 0828-0289 13.7 µM 1.03726615219268 0.158698923015924 no 555 0.14980591785998 180 745350 YLR208W SEC13
SGTC_1693 xanthone 101.9 µM 1.03246996004648 0.159829371835558 no 556 0.150926006570757 213 7020 An insecticide.
SGTC_1788 fluconazole 20 µM 1.0313649033765 0.160090575378094 no 557 0.151184866363624 179 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2233 sulbentine 40.3845 µM 1.02876643701614 0.160705877060136 no 558 0.151794720940438 197 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_890 0929-0006 47.2 µM 1.02765738150224 0.160968964559358 no 559 0.15205551098282 162 1378169
SGTC_1782 st039423 80.636 µM 1.02692545036852 0.161142745407665 no 560 0.152227784610497 160 2068169
SGTC_1271 0832-2808 169 µM 1.02464988226272 0.161683810287801 no 561 0.152764209379618 208 3663794
SGTC_2489 cantharidin 73.42 µM 1.02228444092259 0.162247498149724 no 562 0.153323147549791 171 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2163 5671233 125 µM 1.02207359645818 0.162297804700884 no 563 0.153373034388764 179 701023
SGTC_171 k064-0041 9.68 µM 1.01977657426779 0.162846521786795 no 564 0.153917217789839 174 53325
SGTC_34 0469-0683 81.75 µM 1.01740063730367 0.163415357940689 no 565 0.154481439485446 157 3690923
SGTC_3071 9117417 49.47 µM 1.01672474212343 0.163577413244621 no 566 0.15464219605256 175 45595590 YGL055W OLE1
SGTC_551 k048-0028 34.9 µM 1.01621936038215 0.163698653731966 no 567 0.154762469492737 193 6836383
SGTC_1189 1431-2119 7.28 µM 1.01609300462534 0.163728975443428 no 568 0.154792549964074 192 3107275
SGTC_1267 0828-0272 9.49 µM 1.0158708623926 0.163782291965402 no 569 0.154845442894363 180 745334
SGTC_640 3381-0960 37.1 µM 1.01492723627817 0.164008897958277 no 570 0.155070257002735 188 1745025
SGTC_1178 0988-0033 191 µM 1.01447552158409 0.164117446414215 no 571 0.155177951963724 178 5392207
SGTC_316 k060-0003 58.6 µM 1.01364698257709 0.164316668027979 no 572 0.155375615302311 183 6152314
SGTC_2462 5162487 171.77 µM 1.0107000205648 0.165026533045353 no 573 0.156080013606646 174 2259986
SGTC_949 1165-0505 146 µM 1.00898419948115 0.165440753702382 no 574 0.156491105977825 178 6244267
SGTC_3128 9127691 49.47 µM 1.0059663276989 0.166170936067816 no 575 0.157215883993866 171 41316314
SGTC_3093 9117344 49.47 µM 1.00368494350223 0.166724302818167 no 576 0.157765248315774 163 24824913
SGTC_1167 k781-0610 148 µM 1.00305072598535 0.166878347989265 no 577 0.157918193554908 187 4525169
SGTC_1849 st056239 19.2 µM 1.00167349330438 0.167213180256029 no 578 0.158250656373127 191 5393181
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.999882672958422 0.167649211005657 no 579 0.158683645306154 186 390807
SGTC_2983 9022671 12.99 µM 0.99982954014958 0.167662159011613 no 580 0.158696503740383 175 6405161
SGTC_1689 st020265 53.493 µM 0.998915300309725 0.167885052230804 no 581 0.158917861849532 181 5758320 YPR016C TIF6
SGTC_2291 7917025 104.35 µM 0.998891449870908 0.167890869560073 no 582 0.158923639286231 171 2964612
SGTC_923 1900-2434 73.3 µM 0.995915661803634 0.168617708153407 no 583 0.159645562454252 208 5910570
SGTC_2387 9077560 195.08 µM 0.993765640682591 0.169144109225669 no 584 0.160168488708543 177 5303272
SGTC_1683 st010134 710 nM 0.993663199628607 0.169169216720896 no 585 0.160193432247835 167 3818134
SGTC_1913 st060213 96.1 µM 0.992866726122061 0.169364507726843 no 586 0.160387453497935 202 688959
SGTC_3160 9100216 49.47 µM 0.991390394479863 0.169726878793931 no 587 0.160747494383151 183 17191039
SGTC_2466 5983409 37.09 µM 0.99071131738482 0.169893727626039 no 588 0.16091328161495 181 2879657
SGTC_3078 9116413 49.47 µM 0.990365025785421 0.169978851734848 no 589 0.160997866850016 209 17177322
SGTC_531 3788-1495 174 µM 0.990134134059688 0.170035623866632 no 590 0.161054280617461 172 2896655
SGTC_2869 9037858 32.47 µM 0.986262672219683 0.170989356796265 no 591 0.162002116020119 182 27187042
SGTC_732 3970-1727 52.7 µM 0.985224226911817 0.171245758297414 no 592 0.162256971431136 205 1275699
SGTC_2123 5259487 200 µM 0.984979368471586 0.171306251849842 no 593 0.162317102637016 174 2173474
SGTC_1486 3970-0793 4.53 µM 0.984230294395858 0.171491399313217 no 594 0.162501146848245 205 2844330
SGTC_1388 3346-4487 254 µM 0.98154563297571 0.172156012846253 no 595 0.163161871361647 202 3345614
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.979335016121598 0.172704504465846 no 596 0.16370723713809 182 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1762 st045503 25.4615 µM 0.974222372204341 0.173977300464759 no 597 0.164973069347797 180 4645554
SGTC_2135 5326629 150.42 µM 0.972918397033066 0.17430287807473 no 598 0.165296930382345 175 5020077
SGTC_3012 9080433 71.4286 µM 0.970425858823532 0.174926293556582 no 599 0.16591713219029 202 17688859
SGTC_1176 0848-0131 83.3 µM 0.970232713965507 0.174974660537793 no 600 0.16596525385434 194 6769040
SGTC_1301 naphtanilide LB 4.81 µM 0.968578518511507 0.175389248625524 no 601 0.166377762792839 208 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.967634159747337 0.175626210612728 no 602 0.166613555406558 200 688669
SGTC_1051 3253-3903 78 µM 0.966441317037207 0.175925812920295 no 603 0.166911698943651 219 5509239
SGTC_1751 st044839 27.194 µM 0.96569834202068 0.176112586947556 no 604 0.167097574691193 177 5291326
SGTC_925 2064-1272 59.6 µM 0.965421385339122 0.176182242274555 no 605 0.167166897199669 194 6815817
SGTC_2816 7982706 58.44 µM 0.965079524118543 0.17626824530417 no 606 0.167252490936552 220 2981853
SGTC_1669 st015249 58.4 µM 0.964983257492204 0.176292468174744 no 607 0.1672765988555 185 722793
SGTC_1431 4049-0260 9.09 µM 0.964631820218182 0.176380915658196 no 608 0.167364627821197 209 3854841
SGTC_2956 9076196 2.52 µM 0.962263669751929 0.176977648387243 no 609 0.167958586769779 206 16423868
SGTC_1318 1280-3875 124 µM 0.961907095073488 0.177067609380815 no 610 0.168048137118217 216 373245
SGTC_2876 9059903 25.97 µM 0.960076010305448 0.177530032682039 no 611 0.168508480601476 179 6916095
SGTC_2222 6885208 172.143 µM 0.959931097100054 0.177566661674164 no 612 0.168544947065154 182 609514
SGTC_2566 crystal violet carbinol 226 nM 0.955805657031499 0.1786114288057 no 613 0.169585214877413 236 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2425 5628681 7.85 µM 0.954723954437168 0.178886009140007 no 614 0.169858656346786 195 5714958
SGTC_3188 9110789 49.47 µM 0.95452746416729 0.178935914899996 no 615 0.169908357058696 183 849217
SGTC_1249 0481-0015 10.2 µM 0.953824533521707 0.179114521109733 no 616 0.170086234321666 208 4227577
SGTC_2886 9058944 51.95 µM 0.952231017909309 0.179519829356971 no 617 0.170489916716672 143 4949929
SGTC_2260 7964312 200 µM 0.948815781188076 0.180390429462685 no 618 0.17135715705138 195 231951
SGTC_1461 k072-0203 53.8 µM 0.948730509079035 0.180412200568856 no 619 0.171378846451174 184 5418714
SGTC_2810 7959871 45.46 µM 0.947400894829866 0.18075188203079 no 620 0.171717267664418 206 2974535
SGTC_142 0335-0849 62.6745 µM 0.946486325029391 0.180985763147104 no 621 0.17195029695453 202 3889043 YPR107C YTH1
SGTC_857 0438-0306 1.35 µM 0.944448683020054 0.18150752681459 no 622 0.172470206886269 177 4686136
SGTC_2055 5235184 200 µM 0.944438786837999 0.181510063150767 no 623 0.172472734368178 203 2836034
SGTC_2795 7780010 54.55 µM 0.941781846353992 0.182191824540214 no 624 0.173152170642131 197 953673
SGTC_2647 atorvastatin 60.16 µM 0.940017516083676 0.182645428456444 no 625 0.173604288002955 178 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2225 6654152 15.4 µM 0.939749463265149 0.182714405673042 no 626 0.173673043385463 200 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_203 k066-0004 30.888 µM 0.935227070146905 0.183880590175313 no 627 0.174835645323364 218 6795412
SGTC_2247 cerulenin 830 nM 0.935069014924893 0.183921431361381 no 628 0.174876366774734 197 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_3327 9140648 26.9345 µM 0.934577381867293 0.184048504571831 no 629 0.175003069915972 231 8029710
SGTC_2593 nobiletin 86.24 µM 0.933029314318492 0.184448993071524 no 630 0.175402416550092 187 72344 An anti-infammatory.
SGTC_1530 rhein 70.4 µM 0.932672688990143 0.184541329600267 no 631 0.175494495070958 223 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1185 1319-0113 81.3 µM 0.932645501874754 0.18454836999861 no 632 0.17550151587772 202 4672763
SGTC_1141 3253-0389 52.6 µM 0.932259461684692 0.184648357317158 no 633 0.175601226192917 212 5402031
SGTC_678 1218-2179 85.9 µM 0.931453741117148 0.184857153507476 no 634 0.175809451373371 211 6820081 YOR116C RPO31
SGTC_1944 st076371 56.9 µM 0.931223361614228 0.184916881522198 no 635 0.175869017893874 212 24208455
SGTC_2914 7968218 45.32 µM 0.930176549541805 0.185188428245311 no 636 0.176139840755579 161 2977111
SGTC_2305 7443522 69.23 µM 0.927658885753034 0.1858425324816 no 637 0.176792270883663 199 5415886
SGTC_49 0717-0965 32.132 µM 0.923967777445785 0.186804091278063 no 638 0.17775154634277 210 5889349 YGL099W LSG1
SGTC_1515 3460-0031 42.1 µM 0.923826549586252 0.18684094315363 no 639 0.177788314901343 200 2876596
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.922140077637415 0.187281357273948 no 640 0.178227757179055 246 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1768 st044301 37.178 µM 0.921864256586146 0.187353447652538 no 641 0.178299692670029 248 3931349
SGTC_2139 5578692 56.4705 µM 0.920657962326907 0.187668934072754 no 642 0.178614515106234 210 650991 YMR113W FOL3
SGTC_600 1495-0418 41.6 µM 0.920351228583591 0.187749207543765 no 643 0.178694623224192 219 5377768
SGTC_1777 st045864 34.765 µM 0.917936857069413 0.188381798629256 no 644 0.179325962143548 244 4691462
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.917803822789902 0.188416693203805 no 645 0.179360790271052 222 91467 include heat shock
SGTC_2488 5268135 45.7 µM 0.916296080881708 0.188812448892371 no 646 0.1797558115089 207 1270356 YLR208W SEC13
SGTC_700 3453-2283 142 µM 0.915932108061093 0.188908062048027 no 647 0.179851252498358 203 565664
SGTC_3144 9087057 49.47 µM 0.915024428047812 0.189146633270527 no 648 0.180089403072911 181 17249618
SGTC_677 0929-0063 136 µM 0.915008531311578 0.189150813161755 no 649 0.180093575707814 221 1539583
SGTC_1646 st011709 75.6 µM 0.912617900884907 0.189780053390756 no 650 0.180721768125766 203 5757843
SGTC_2007 4011539 71.82 µM 0.912477560234198 0.189817032553175 no 651 0.180758688460382 177 45595301
SGTC_496 calpeptin 138 µM 0.911237500116332 0.190143975612498 no 652 0.181085124658456 186 73364 A calpain inhibitor.
SGTC_2092 5303694 80.6725 µM 0.909919317651896 0.190491894868214 no 653 0.181432530643212 204 1963699
SGTC_1748 st037455 53.6035 µM 0.906082997848987 0.191506669952795 no 654 0.182445961872883 198 580690
SGTC_2888 9058547 12.99 µM 0.905110837759403 0.191764348684126 no 655 0.182703335559685 170 16476514
SGTC_2736 butenafine 14.65 µM 0.904496097556567 0.191927399958088 no 656 0.182866201359966 199 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2586 curcumin 80 µM 0.903519214430319 0.192186679104035 no 657 0.183125197603597 203 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_772 k072-0172 35.3 µM 0.902906347306946 0.192349452380183 no 658 0.18328780081514 172 5861980
SGTC_3178 9107506 49.47 µM 0.901072918569831 0.192836901524545 no 659 0.183774775388689 203 8897194
SGTC_1644 st010134 20.9 µM 0.900487795357517 0.192992625484608 no 660 0.183930358689194 224 3818134
SGTC_2716 st080858 38.6235 µM 0.900441080328363 0.19300506147347 no 661 0.183942783673404 208 5296050
SGTC_733 4069-0007 56.1 µM 0.898251024334291 0.193588624486779 no 662 0.184525868198131 217 5717425 YNL287W SEC21
SGTC_1353 1498-1206 8.11 µM 0.897901094714177 0.193681966449193 no 663 0.184619140501705 206 6756808
SGTC_2266 7929956 200 µM 0.896766622319775 0.193984769895608 no 664 0.184921730999992 213 2967153
SGTC_1518 st038567 90.8 µM 0.896737415962939 0.193992569207718 no 665 0.184929525090039 224 77966
SGTC_527 4476-4215 268 µM 0.896338048414093 0.194099236123502 no 666 0.185036121910109 183 4418754
SGTC_954 1189-0853 2.85 µM 0.895279791670155 0.194382058215182 no 667 0.185318770077399 208 2828194
SGTC_2960 9079389 5.97 µM 0.892946059643758 0.1950066407503 no 668 0.185943029767979 179 16457355
SGTC_2075 5212009 200 µM 0.892063603247277 0.195243132320277 no 669 0.186179421048783 215 780898
SGTC_3191 9110352 49.47 µM 0.8913470495581 0.195435291383489 no 670 0.186371507482217 205 17122424
SGTC_1029 k015-0030 64.7 µM 0.890972235247766 0.195535851530066 no 671 0.186472032782744 214 2208316
SGTC_2925 9010536 32.5 µM 0.890532095391991 0.195653978183631 no 672 0.186590121275918 190 2994177
SGTC_2968 9090663 33.37 µM 0.890213913153549 0.195739400294436 no 673 0.186675517656509 245 25236811
SGTC_769 0302-0231 76 µM 0.887913795990894 0.196357583827421 no 674 0.187293561557879 236 571869 YER009W NTF2
SGTC_1090 efavirenz 20.7 µM 0.884998173293379 0.197142890306381 no 675 0.188078808291626 204 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2473 5854593 8.94 µM 0.88418983626507 0.19736094733652 no 676 0.188296872002111 211 2872951
SGTC_3030 9087619 49.47 µM 0.883930058487076 0.197431055961529 no 677 0.188366984918692 225 25236973
SGTC_209 4077-0173 175.592 µM 0.880892389539374 0.198251976879977 no 678 0.189188033519103 200 15993494
SGTC_1437 4092-1038 11.6 µM 0.880492896826715 0.198360091675793 no 679 0.189296175740252 232 3977136
SGTC_355 1311-2252 105 µM 0.879918693569936 0.198515550729542 no 680 0.189451678547155 211 5338538
SGTC_1193 1488-0126 41.5 µM 0.879292534712277 0.198685159923264 no 681 0.189621341281356 205 1384710
SGTC_3062 9077494 49.47 µM 0.877826435494552 0.199082627518753 no 682 0.190018958039165 199 16459633
SGTC_1092 toremifene 6.32 µM 0.877811997921974 0.199086544004883 no 683 0.190022876160131 221 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3108 9121785 49.47 µM 0.877006069458316 0.199305242155049 no 684 0.190241670704994 214 17140271
SGTC_3149 9097855 49.47 µM 0.87625261570722 0.199509831465478 no 685 0.190446359263387 198 25236625 YMR079W SEC14
SGTC_1268 0828-0275 2.46 µM 0.87560228510057 0.199686520798891 no 686 0.190623141358433 216 745337
SGTC_92 0063-0024 660.874 µM 0.875006840279676 0.199848380663709 no 687 0.190785091925804 235 3594437
SGTC_1899 st063254 59.6 µM 0.872638803636424 0.200492864964968 no 688 0.191429991573481 201 3093813
SGTC_3278 9139605 49.47 µM 0.872388136514829 0.200561159451799 no 689 0.191498335140369 226 7958859
SGTC_322 k048-0136 19.3 µM 0.870990525134537 0.200942195956658 no 690 0.191879663257391 218 6823282
SGTC_785 1270-0111 65.3 µM 0.86943782083332 0.201366024973893 no 691 0.192303851993752 220 6741994
SGTC_3026 9090633 49.47 µM 0.86928511350717 0.201407737166492 no 692 0.192345601598108 228 25236842
SGTC_2607 solasodine 47.35 µM 0.868442195686058 0.201638074366952 no 693 0.192576151862121 242 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_958 1222-0007 33 µM 0.865941614532831 0.202322315348607 no 694 0.193261090289495 234 7312461
SGTC_2060 5238662 140 µM 0.86112934326327 0.203643011990342 no 695 0.194583404815376 230 790130
SGTC_1588 farnesol 29.9 µM 0.860079048365732 0.20393194056302 no 696 0.194872734820374 215 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2802 7925815 54.55 µM 0.859658824657367 0.204047609469612 no 697 0.194988569196559 209 1262923
SGTC_2703 st077852 53.4 µM 0.857144720530633 0.204740446590267 no 698 0.195682454309116 233 6281836
SGTC_297 0986-0032 24 µM 0.853689327266969 0.20569496407171 no 699 0.196638574612199 234 2847425
SGTC_2099 5377090 177.372 µM 0.853059239979309 0.205869303595484 no 700 0.196813226711278 227 2243829
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.852912187946989 0.205910004192546 no 701 0.196854001160388 236 65057 A dermal irritant. YDR527W RBA50
SGTC_2946 9065502 71.43 µM 0.852256638037562 0.206091503287357 no 702 0.197035833638097 176 16489101
SGTC_3232 9132874 49.47 µM 0.852085782219763 0.206138822932857 no 703 0.197083241288228 213 3784940
SGTC_1743 st037606 46.3785 µM 0.851784067439017 0.206222400561051 no 704 0.197166975450379 182 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1314 1222-0010 41.1 µM 0.850945251547624 0.206454865412543 no 705 0.197399883051045 216 3526027
SGTC_1961 st076550 68.7 µM 0.846113731784654 0.207796865942636 no 706 0.198744650522233 238 1579337
SGTC_1074 carmofur 3.8 µM 0.844183804827117 0.208334358284818 no 707 0.199283351496112 241 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2295 7971645 200 µM 0.842848018345163 0.208706859933485 no 708 0.199656724309891 202 2978226 YKL099C UTP11
SGTC_3196 9111891 49.47 µM 0.841608335444177 0.20905291277978 no 709 0.20000361100449 240 18891510
SGTC_275 trichlorophene 5.69 µM 0.840869662613907 0.209259271096684 no 710 0.200210477789785 217 62616
SGTC_662 k832-1615 104 µM 0.840462949058059 0.209372943233698 no 711 0.200324433593848 224 5878478
SGTC_849 0386-0493 241 µM 0.839606625070636 0.209612395490103 no 712 0.200564491706619 236 726119
SGTC_2806 7952793 58.44 µM 0.83909050107722 0.209756796025795 no 713 0.200709263040842 213 2972490
SGTC_1884 5633444 25 µM 0.838239308601059 0.209995069331907 no 714 0.200948157133313 237 5724239
SGTC_2930 9013230 14.89 µM 0.836858660430351 0.210381890572192 no 715 0.201336009841376 223 2995857
SGTC_2238 6671620 73.2395 µM 0.836483311389018 0.210487125761476 no 716 0.201441530702132 210 729941
SGTC_2747 doxorubicin 7.63 µM 0.835755361943666 0.210691306231924 no 717 0.201646271604766 178 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_835 0312-0010 67.2 µM 0.835616213300196 0.210730348863326 no 718 0.201685422325741 245 1626196
SGTC_3010 9080089 71.4286 µM 0.834967092076441 0.210912536788052 no 719 0.201868118564039 217 17027233
SGTC_2972 9093619 59.92 µM 0.834824754821083 0.210952498724473 no 720 0.201908192860566 202 25236256
SGTC_1022 4477-0945 21.3 µM 0.834492310668647 0.211045851467036 no 721 0.202001809291819 218 4648966
SGTC_1025 k007-0731 70 µM 0.834255508366212 0.211112362045663 no 722 0.202068508773482 227 6256118
SGTC_1763 st044482 94.5 µM 0.832839892346303 0.211510221762616 no 723 0.202467516436405 248 88505
SGTC_3058 9093861 49.47 µM 0.832640419293962 0.211566319050331 no 724 0.202523778052828 223 17217477
SGTC_537 1334-0398 209 µM 0.830686179807517 0.21211636526037 no 725 0.203075467825943 227 5846986
SGTC_2515 chrysin 20.77 µM 0.830030551719861 0.212301087489865 no 726 0.203260755134953 211 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_884 0851-0618 334 µM 0.829864714227918 0.212347826847967 no 727 0.203307638516486 243 9642473
SGTC_189 3970-0742 2.116 µM 0.8298436554563 0.212353762446764 no 728 0.203313592435497 220 2891807
SGTC_358 0075-0058 9.45 µM 0.828075530982472 0.212852469495679 no 729 0.203813862992921 250 1069125
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.826792688048879 0.213214728344694 no 730 0.204177287567706 222 15053
SGTC_1483 3453-0561 55.9 µM 0.826570345382826 0.213277551680122 no 731 0.204240315628315 226 4546991
SGTC_1225 1216-0074 20.6 µM 0.823073611260027 0.214266979210939 no 732 0.205233067107566 235 4241466
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.820851245799108 0.21489719980723 no 733 0.205865502275224 220 23665772 A membrane-active detergent.
SGTC_2620 irigenin 100 µM 0.81981808059274 0.215190552059989 no 734 0.206159911098709 231 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_623 k072-0108 16.9 µM 0.819490043773868 0.215283741943447 no 735 0.206253440040778 239 5382803
SGTC_2522 biochanin a 4.94 µM 0.816599009653524 0.21610604946879 no 736 0.207078810619622 221 5280373 A possible chelator.
SGTC_912 3474-0017 2.18 µM 0.816336093454963 0.21618092182809 no 737 0.207153968214892 222 3360550
SGTC_1375 2910-0797 186 µM 0.816012072441047 0.216273216064205 no 738 0.207246615511147 244 742508
SGTC_2707 st078556 66.6 µM 0.81534707054639 0.216462706825356 no 739 0.207436836171527 218 17250899
SGTC_2754 granisetron 64.02 µM 0.814953856209293 0.216574797531812 no 740 0.207549361819301 244 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_3334 9142812 21.919 µM 0.813746285073195 0.216919240751403 no 741 0.207895156338407 223 45283678
SGTC_1020 4335-0961 93.3 µM 0.813542846913372 0.21697729986663 no 742 0.207953445420349 242 669075
SGTC_2241 6772625 37.8075 µM 0.809606137079046 0.218102562722114 no 743 0.209083289878236 228 2285411
SGTC_2237 6667747 47.222 µM 0.808925257017217 0.218297525020949 no 744 0.20927906998906 237 729940 YDL015C TSC13
SGTC_2390 9097792 176.6 µM 0.807394412004049 0.218736231618046 no 745 0.209719642671655 226 4497149
SGTC_1331 1472-0049 76.2 µM 0.806731239441956 0.21892643973089 no 746 0.209910670953399 259 24051409
SGTC_3261 9137475 49.47 µM 0.805352118300549 0.219322297451715 no 747 0.210308257073996 177 17027690
SGTC_1967 st070177 51.4 µM 0.805039654455019 0.219412043017104 no 748 0.210398398517019 232 5729214
SGTC_2691 st077356 60.2 µM 0.804410347970524 0.219592855847724 no 749 0.210580013449839 236 2839272
SGTC_1282 0886-0010 32.4 µM 0.802409411899081 0.22016833465249 no 750 0.211158085246036 242 2836211 YNL267W PIK1
SGTC_1636 st007707 68.9 µM 0.801223112004322 0.220509928196924 no 751 0.211501246751187 252 403051
SGTC_2093 5331342 194.4 µM 0.800933488569645 0.220593370996289 no 752 0.211585075819286 237 33839
SGTC_3181 9108277 49.47 µM 0.800147096331339 0.220820028032948 no 753 0.211812788526082 243 17097298
SGTC_739 1486-1183 203 µM 0.800117726423129 0.220828495724769 no 754 0.211821295839101 218 4346692
SGTC_3024 9090631 49.47 µM 0.799773610093293 0.22092772238159 no 755 0.211920987765752 224 25236383
SGTC_2385 9074692 200 µM 0.799210198375706 0.221090238409259 no 756 0.212084269716024 224 17046906
SGTC_1631 benzylvanillin 81.9 µM 0.798944731908764 0.221166835876254 no 757 0.212161229854005 222 75506
SGTC_1878 temozolomide 1 mM 0.797144332889138 0.221686721949375 no 758 0.21268360577131 233 5394 DNA alkylating agent.
SGTC_471 1-acyl-paf 4 µM 0.795308604528571 0.222217528011724 no 759 0.213217004767127 232 16759367
SGTC_277 nystatin 15.5 µM 0.794727582502312 0.222385683159512 no 760 0.213385992013054 257 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2650 prasterone 100 µM 0.794026787567424 0.222588598640156 no 761 0.21358991842748 212 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2909 7941780 10.49 µM 0.791624597677785 0.223284954279352 no 762 0.214289800002626 228 1243215
SGTC_651 3253-0966 34.4 µM 0.791301513474298 0.223378705617622 no 763 0.214384032731561 241 781462
SGTC_2924 9010168 62.78 µM 0.790599510788613 0.223582487258704 no 764 0.214588866206686 243 2993929
SGTC_737 1950-0117 57.9 µM 0.789843904251336 0.223801947452489 no 765 0.214809467522543 241 5393513
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.789478991897996 0.223907977310724 no 766 0.214916051805383 247 5282362
SGTC_1789 tunicamycin 25 nM 0.788588103846633 0.224166955881679 no 767 0.215176393052728 254 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2965 9082772 38.63 µM 0.787965600838767 0.224348016613266 no 768 0.21535841362642 180 16459634
SGTC_2038 4100038 30.985 µM 0.787548893590555 0.224469266123618 no 769 0.215480309191765 242 3596803
SGTC_1443 4112-3303 14 µM 0.785866981976146 0.224959030532197 no 770 0.215972709993944 261 704433
SGTC_2714 st079313 56.9 µM 0.785077813809845 0.225189041030657 no 771 0.216203973423763 229 2939799
SGTC_1844 rapamycin 4 nM 0.783936522101904 0.225521916773897 no 772 0.21653867913597 245 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1888 azatryptophan 97.5 µM 0.782786748786593 0.225857547743585 no 773 0.21687617518524 200 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2855 9016525 58.44 µM 0.78182287311402 0.226139130756274 no 774 0.21715933837086 238 43811474
SGTC_2800 7887935 81.82 µM 0.78103694667857 0.226368875104287 no 775 0.217390382401042 240 2961002
SGTC_3189 9110682 49.47 µM 0.780560281446109 0.226508279497401 no 776 0.217530579972294 233 17122418
SGTC_1824 st053723 68.6 µM 0.780144763266553 0.226629840499343 no 777 0.21765283543367 248 675225
SGTC_2337 9009472 200 µM 0.77975491132286 0.226743926245556 no 778 0.217767575310472 238 5742383
SGTC_1729 st035615 45.989 µM 0.778130199047601 0.227219728637089 no 779 0.21824613056999 250 17385451
SGTC_1581 himbacine 57.9 µM 0.776174943810943 0.227793076976057 no 780 0.218822849118796 255 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_945 3381-0768 11.3 µM 0.775944617450023 0.22786067018021 no 781 0.218890843450066 257 1126236 YIL048W NEO1
SGTC_872 0588-0139 234 µM 0.775867735196568 0.227883235102535 no 782 0.218913542460834 224 2047100
SGTC_3095 9117207 49.47 µM 0.775771487416348 0.227911485574302 no 783 0.218941960932436 207 17015229
SGTC_1470 k295-0292 231 µM 0.775366158790758 0.228030478507141 no 784 0.219061663028534 267 5045612
SGTC_2612 dictamnine 15.46 µM 0.775308701328337 0.228047349207862 no 785 0.219078634474649 245 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2704 st078022 71.1 µM 0.77041309542918 0.22948737600695 no 786 0.220527443892563 241 54697681
SGTC_2597 laccaic acid a 100 µM 0.770264608125786 0.229531132546082 no 787 0.220571472956008 239 5491415 A textile dye.
SGTC_1684 st024538 14.6195 µM 0.76832166340513 0.230104114016245 no 788 0.221148053727571 241 6732859
SGTC_1117 retinoic acid 1.10837 µM 0.76615407041339 0.230744288412387 no 789 0.22179231672546 247 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2417 cerulenin 830 nM 0.766138669034002 0.230748840594547 no 790 0.221796898234429 245 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2863 9028737 58.44 µM 0.765061460350619 0.231067355342998 no 791 0.222117473837394 255 6460917
SGTC_2136 5328288 199.296 µM 0.7648995801683 0.231115242129434 no 792 0.222165671971771 241 262395
SGTC_1874 staurosporine 7.6 µM 0.764659393726554 0.231186303382471 no 793 0.222237195974533 254 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_991 3996-0057 64.7 µM 0.764317351691141 0.231287520539431 no 794 0.222339073755481 239 715343
SGTC_955 1216-0110 33 µM 0.764168026280565 0.231331716699168 no 795 0.222383558927062 246 3619719
SGTC_1866 st057638 64 µM 0.761935294344767 0.231993104591391 no 796 0.223049311879767 228 688802
SGTC_1326 1431-2094 10.8 µM 0.76024500568373 0.232494507431598 no 797 0.22355407381723 262 616278
SGTC_1289 0976-0073 69.1 µM 0.759075848260575 0.232841675522922 no 798 0.223903592871122 241 3391136
SGTC_2486 5283202 22.39 µM 0.758173635613871 0.233109774142824 no 799 0.224173521056993 244 1377751
SGTC_1833 st055984 71 µM 0.75730500280346 0.233368056143395 no 800 0.224433577191266 241 676288
SGTC_1056 3448-1962 115 µM 0.756844652993935 0.233505002343463 no 801 0.224571468667472 250 715507
SGTC_2752 diclazuril 33.15 µM 0.756504411514978 0.233606247007164 no 802 0.22467341422169 240 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2478 5763493 32.33 µM 0.756114441892392 0.233722319061136 no 803 0.224790291950437 250 1365576 YLR208W SEC13
SGTC_630 4356-0227 183 µM 0.755246879326719 0.233980658347703 no 804 0.225050432602435 267 779312
SGTC_740 k014-0057 261 µM 0.75447282874399 0.234211285475608 no 805 0.225282677400689 256 4012779
SGTC_2964 9083345 53.42 µM 0.754356081772188 0.234246080967373 no 806 0.225317717736166 260 17741579
SGTC_820 1582-0060 59.9 µM 0.752411566899912 0.234826048489638 no 807 0.22590179636211 255 3848840
SGTC_2963 9082507 9 µM 0.750477611395059 0.235403652978363 no 808 0.226483551470154 243 16459611
SGTC_2393 9031399 185.94 µM 0.75021785248475 0.235481293517578 no 809 0.226561754198709 255 1526623 YDL150W RPC53
SGTC_2713 st079149 53.4 µM 0.748854620800242 0.235888987702731 no 810 0.226972417042484 252 3103253
SGTC_101 0490-5701 117.494 µM 0.747348316516051 0.236339921927152 no 811 0.227426667156079 238 4661669
SGTC_42 0133-0086 60.653 µM 0.747104538083859 0.236412945161142 no 812 0.227500230550738 287 162923 Model of phenazepam hydroxylation.
SGTC_3148 9097893 49.47 µM 0.747050490778806 0.23642913658122 no 813 0.227516541860915 226 17174100
SGTC_3223 9129970 49.47 µM 0.746411499203122 0.236620611092221 no 814 0.227709437466822 270 17248386
SGTC_269 exalamide 29 µM 0.746225407885376 0.236676389591376 no 815 0.227765631094162 246 3316 A derivative of salicylamide.
SGTC_382 3229-0966 23.2 µM 0.74556624042829 0.236874024802914 no 816 0.227964741361524 256 5722370
SGTC_77 0828-0286 12.516 µM 0.74527622314473 0.23696100811402 no 817 0.228052375933604 239 745345
SGTC_590 k048-0076 22.4 µM 0.744898920856475 0.23707419661714 no 818 0.228166413783617 267 6832814
SGTC_1617 st002906 78 µM 0.74446778506393 0.237203571222786 no 819 0.22829676179961 260 5150859
SGTC_1457 k015-0032 57.3 µM 0.743214299949262 0.237579935425794 no 820 0.228675973540363 256 4302660
SGTC_3125 9127534 49.47 µM 0.742327609112704 0.237846365872006 no 821 0.22894443395691 232 1639235
SGTC_2011 4012611 177 µM 0.742233699037079 0.237874593308272 no 822 0.228972877149738 257 2049887
SGTC_2870 9038528 12.99 µM 0.741272078066968 0.23816374247073 no 823 0.229264244005726 252 6463316
SGTC_421 streptovitacin 30 mM 0.740987795061073 0.238249260204666 no 824 0.229350420281389 260 91467 include heat shock
SGTC_391 gliotoxin 8.33 µM 0.739924794737178 0.238569179914618 no 825 0.229672814270493 269 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2120 5538279 151.968 µM 0.737968041292782 0.23915869712772 no 826 0.230266934950054 242 2058197
SGTC_840 0245-0196 390 µM 0.736997349525571 0.239451435616284 no 827 0.230561980592717 245 3827528
SGTC_82 0054-0107 293.755 µM 0.736127668306629 0.239713877727305 no 828 0.230826503014222 245 3104697
SGTC_2827 7993847 71.43 µM 0.736028806729899 0.239743720936947 no 829 0.230856583496665 233 2985692
SGTC_3009 9080819 71.4286 µM 0.733237974241233 0.240587021576707 no 830 0.23170664901044 245 17027216
SGTC_1047 2043-3044 82 µM 0.733212512561173 0.240594722711914 no 831 0.231714412457289 295 669592
SGTC_1830 st055982 50.3 µM 0.731987919176667 0.240965271409445 no 832 0.232087970739784 274 455313 An antimicrobial agent.
SGTC_953 1188-0045 9.7 µM 0.728685889671997 0.24196597479234 no 833 0.23309691302392 257 6144426
SGTC_1102 cgs 12066b 26.1 µM 0.725565172818506 0.242913798194835 no 834 0.234052688971957 248 6438352 A 5-HT1B full agonist.
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.723517018995872 0.243536953140681 no 835 0.234681150978992 289 229346 A bile salt which induces apoptosis.
SGTC_2742 clothiapine 36.27 µM 0.723403128562474 0.243571629859223 no 836 0.234716124845209 238 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1773 st048542 73.5835 µM 0.72310110510047 0.243663601175137 no 837 0.234808885201728 271 3237138
SGTC_3208 9114115 49.47 µM 0.72253638023308 0.243835619864678 no 838 0.234982383301195 260 650895
SGTC_3067 9117431 49.47 µM 0.721180185255376 0.244248992802683 no 839 0.235399330664582 282 17150885
SGTC_1004 4084-0029 199 µM 0.720267728988647 0.244527325093656 no 840 0.235680085017015 257 716894 YLR208W SEC13
SGTC_1661 st013063 9.66 µM 0.720263660372058 0.244528566551941 no 841 0.235681337306129 279 721395
SGTC_399 oxolinic acid 75 µM 0.719733334421265 0.244690414139381 no 842 0.235844598994248 257 4628 A DNA gyrase inhibitor.
SGTC_1909 st060837 51.5 µM 0.718670613366541 0.245014914316097 no 843 0.236171946932024 262 678937
SGTC_2194 5927483 104.545 µM 0.717100701368601 0.245494707736993 no 844 0.236655981513262 232 760979
SGTC_1071 trifluoperazine 6.31 µM 0.716404399400622 0.245707671658881 no 845 0.23687083960591 277 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2617 dihydrotanshinone i 20.83 µM 0.716162952711313 0.245781541272725 no 846 0.236945367912977 262 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2551 apiole 73.87 µM 0.714963258663964 0.246148759421287 no 847 0.237315873306166 246 10659 A possible DNA adduct former.
SGTC_594 1487-1584 10.8 µM 0.714078398319596 0.246419797560846 no 848 0.237589351331699 280 5013332
SGTC_1411 3909-8223 150 µM 0.713454192732881 0.246611091717833 no 849 0.237782374471395 268 X1411
SGTC_144 4161-2749 112.381 µM 0.709872247287669 0.247710351505373 no 850 0.238891680928755 271 797501 YMR168C CEP3
SGTC_2450 5739737 12.93 µM 0.709336238827788 0.247875071406375 no 851 0.239057922555742 270 2262825
SGTC_2830 7992007 71.43 µM 0.707689355554052 0.248381538032165 no 852 0.239569094528016 267 1952075
SGTC_1926 methyl fluorone black 53.6 µM 0.707439021313187 0.248458571679967 no 853 0.239646847355247 233 72721 Reacts with homocysteine.
SGTC_125 0133-0007 11.75 µM 0.706991468125343 0.248596325891248 no 854 0.239785889925577 267 26541
SGTC_1428 4049-0204 61.7 µM 0.706161677633157 0.248851838081136 no 855 0.240043799613191 281 X1428
SGTC_1488 4013-0813 75.9 µM 0.705540209904816 0.249043294267656 no 856 0.240237058885164 261 2910057
SGTC_364 0083-0097 67.7 µM 0.705323278085699 0.249110143118547 no 857 0.240304538638321 260 5207356
SGTC_3321 9137793 26.8275 µM 0.703404516220742 0.249701836536147 no 858 0.240901846424155 274 4904192
SGTC_2289 7946404 165.07 µM 0.69991470950494 0.250779907322026 no 859 0.241990285310636 262 1246120 YPR165W RHO1
SGTC_702 1488-0190 94 µM 0.696697713383482 0.251775880215662 no 860 0.242995995055448 250 949357
SGTC_1499 4480-0877 67.3 µM 0.695963786594081 0.252003394107166 no 861 0.243225754410826 264 2861909
SGTC_518 1021-0119 62.6 µM 0.695653743982958 0.252099538458048 no 862 0.243322850033052 279 1097762
SGTC_3133 9127736 49.47 µM 0.692466016633038 0.253089175270846 no 863 0.244322360075155 259 27243420
SGTC_205 1486-1330 71.903 µM 0.69120221574489 0.253482089938455 no 864 0.244719235820245 268 4118834
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.691056990401609 0.253527260902992 no 865 0.244764863659028 282 23847180
SGTC_2113 5491891 107.031 µM 0.690946035902766 0.25356177509637 no 866 0.244799727147914 274 789979
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.690181369219614 0.253799704157622 no 867 0.245040069018608 303 368090
SGTC_2351 9026858 72.31 µM 0.69009723404391 0.253825890305936 no 868 0.245066521238398 288 1409300
SGTC_3142 9086498 49.47 µM 0.689783756963186 0.25392346908579 no 869 0.245165092403006 267 25236367
SGTC_1168 k815-0004 80.5 µM 0.688410046376913 0.254351308164804 no 870 0.245597299545681 284 642433
SGTC_1448 4255-0083 152 µM 0.688151058423641 0.254432011694943 no 871 0.245678830108517 294 5399660
SGTC_2594 a-mangostin 100 µM 0.686181006203913 0.255046340894172 no 872 0.246299486821723 284 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2826 7992541 19.48 µM 0.685132751066995 0.255373538457858 no 873 0.246630077520769 326 2985066
SGTC_3304 9125678 46.087 µM 0.684504372808937 0.255569782692428 no 874 0.246828364532156 278 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2857 9024691 58.44 µM 0.684371706629169 0.255611224768958 no 875 0.246870238728485 293 16478292
SGTC_1338 1486-1223 76 µM 0.684025387782057 0.255719423905645 no 876 0.246979567272313 265 3444526
SGTC_2202 7226349 200 µM 0.683196373606998 0.255978526889415 no 877 0.247241381916227 257 844334
SGTC_1191 1487-1166 10.6 µM 0.682876395334359 0.256078570639468 no 878 0.247342475353304 291 3955771
SGTC_2643 anethole 100 µM 0.682647681934236 0.256150092197994 no 879 0.247414748247885 299 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1671 st016596 74.5 µM 0.681539535506609 0.256496770979595 no 880 0.247765079663209 284 2829167
SGTC_2640 pentamidine 10.38 µM 0.681496808432241 0.25651014285099 no 881 0.247778592778769 274 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1749 st037932 54.2 µM 0.680755052931759 0.256742340622625 no 882 0.248013247429633 292 594497
SGTC_911 3456-4043 236 µM 0.6778905613287 0.257640061921001 no 883 0.248920542485611 276 914281
SGTC_414 piperonyl butoxide 100 µM 0.677850297904337 0.257652691938131 no 884 0.248933308043826 272 5794 A potent inhibitor of cytochrome P450.
SGTC_448 monastrol 171 µM 0.677511178080197 0.257759081367597 no 885 0.249040840140998 291 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1571 st070080 73.4 µM 0.676590011238549 0.258048186940398 no 886 0.249333059241868 278 4315245
SGTC_547 1120-0019 610 nM 0.676120698031717 0.25819554418436 no 887 0.249482008178926 263 3676939
SGTC_778 3456-2434 196 µM 0.675753337050332 0.258310920402275 no 888 0.249598632869156 246 5539063
SGTC_646 4092-0839 27.3 µM 0.674993441973992 0.258549663666425 no 889 0.249839965746047 289 877796
SGTC_2101 5377231 179.231 µM 0.674084688728295 0.2588353250477 no 890 0.250128736626693 292 2844213
SGTC_109 0132-0036 33.701 µM 0.671945235400155 0.259508494210402 no 891 0.25080928058299 254 67274 A color developer.
SGTC_402 epigallocatechin gallate 10 µM 0.671917758674291 0.259517145512644 no 892 0.250818027093417 288 65064 An antioxidant.
SGTC_703 3875-0075 71.8 µM 0.671634387224092 0.259606376332523 no 893 0.250908240540866 309 2850814
SGTC_509 pifithrin 175 µM 0.670365882583761 0.260006009755753 no 894 0.251312289023214 294 4817 A p53 inhibitor.
SGTC_293 4049-0273 38.5 µM 0.667900220208748 0.260783705872253 no 895 0.252098643413483 273 1380311
SGTC_566 0958-0068 16.5 µM 0.667369946437602 0.260951116089417 no 896 0.252267928903644 286 6815365
SGTC_2998 9066762 71.4286 µM 0.664933031112741 0.261721173015813 no 897 0.253046663845439 288 4945196
SGTC_1886 st057356 49.9 µM 0.664659384781098 0.261807717078614 no 898 0.253134188540098 274 24207747
SGTC_1556 plumbagin 1.48 µM 0.664215642946132 0.26194808715971 no 899 0.253276151446058 278 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_728 3030-5151 22.5 µM 0.663956883448885 0.262029959074965 no 900 0.253358953695731 287 3125388
SGTC_1372 2752-0194 270 µM 0.663349303021531 0.26222225003221 no 901 0.253553433495662 270 823334
SGTC_20 0481-0013 4.944 µM 0.663207801071376 0.262267043855411 no 902 0.253598737967628 285 182045
SGTC_2386 9075165 157.42 µM 0.662546584957535 0.262476410208208 no 903 0.253810494907381 276 16452277
SGTC_68 0986-0284 82.829 µM 0.661609644599321 0.262773227870594 no 904 0.254110712451695 266 423278 YIL048W NEO1
SGTC_2929 9013348 24.6 µM 0.66058902103727 0.263096751173862 no 905 0.254437955883355 290 2995952
SGTC_1364 1653-0028 37.6 µM 0.65948506819392 0.263446917684445 no 906 0.254792165721122 270 5718652
SGTC_2292 7671323 168.05 µM 0.658856708182105 0.263646335495814 no 907 0.254993893991772 303 937504
SGTC_619 1652-1634 108 µM 0.651974837934007 0.26583541063093 no 908 0.257208702343311 285 5400454
SGTC_2560 caryophyllene 100 µM 0.649795554864143 0.26653054090044 no 909 0.257912145320899 284 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2700 st077718 96.8 µM 0.645722584126176 0.267832164432772 no 910 0.259229515951871 283 904970
SGTC_2969 9091408 28.7 µM 0.64487300052793 0.268104074001016 no 911 0.259504744868056 287 4286311
SGTC_2363 9053361 176 µM 0.642905121197157 0.268734427751732 no 912 0.260142833101716 298 6469797 YMR079W SEC14
SGTC_846 0335-0850 148 µM 0.642812238128977 0.268764198570792 no 913 0.260172970570154 279 6819598
SGTC_1376 2910-0861 41.3 µM 0.642106809832445 0.268990356034522 no 914 0.2604019173252 296 1112859
SGTC_556 4058-0063 51.5 µM 0.641436291001562 0.269205410181897 no 915 0.260619630368703 288 6615692
SGTC_848 0368-0089 85.6 µM 0.641341897849303 0.269235691630586 no 916 0.260650286724635 295 762535
SGTC_1711 st032263 62.8 µM 0.640882309986595 0.269383152433722 no 917 0.260799575009437 306 3958979
SGTC_59 0330-0160 1.33 µM 0.638453263501251 0.270163194716018 no 918 0.261589334099219 306 4293482
SGTC_302 1094-0063 18.9 µM 0.636790305234282 0.270697872963763 no 919 0.262130720908241 285 5440289
SGTC_3312 9133330 71.43 µM 0.633675775147018 0.271700683411299 no 920 0.263146218777772 314 17617324
SGTC_1399 3562-5772 25 µM 0.632741609562593 0.272001824366019 no 921 0.263451196437992 296 23847490
SGTC_1653 st012112 65 µM 0.624789703007272 0.274571929897125 no 922 0.266054544848477 302 720429
SGTC_1638 st008370 60.6 µM 0.624629387933672 0.274623867665292 no 923 0.266107163547269 278 24207134
SGTC_1304 1165-0502 251 µM 0.623206037207468 0.275085207373088 no 924 0.266574567461481 287 767425
SGTC_1081 sertraline 6 µM 0.622704390740878 0.275247893100605 no 925 0.266739398424602 299 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2016 5121758 140 µM 0.622393086259031 0.275348874057333 no 926 0.266841712727142 296 2795203
SGTC_2628 lathosterol 100 µM 0.621974998184634 0.275484522156653 no 927 0.266979154050355 279 6710616
SGTC_1490 4089-0339 670 nM 0.621392026095994 0.27567372150319 no 928 0.267170858636492 304 742542
SGTC_3207 9114163 49.47 µM 0.620826891364846 0.275857192820763 no 929 0.267356763888048 338 849233
SGTC_2772 vinpocetine 57.06 µM 0.619911252105291 0.276154582921375 no 930 0.267658108656192 329 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2105 5350118 200 µM 0.619678345516697 0.276230253654634 no 931 0.267734787522621 298 2133313
SGTC_1395 3486-0190 4.35 µM 0.618491487676046 0.27661601858551 no 932 0.268125703633778 307 6748079
SGTC_3172 9105863 49.47 µM 0.61610475943898 0.277392576408378 no 933 0.268912690533015 295 2348785
SGTC_1879 gemcitabine 100 µM 0.613498693081169 0.278241714616032 no 934 0.269773323331018 324 60750 A nucleoside analog which inhibits DNA replication.
SGTC_55 0767-0285 6.563 µM 0.612252072097914 0.278648350498004 no 935 0.270185497197228 313 3116166
SGTC_2635 hydroquinidine 100 µM 0.611928874172481 0.278753821797416 no 936 0.270292408441581 290 442912 An experimental heart treatment.
SGTC_690 glyoxal 20.3 µM 0.611787399384612 0.278799996307268 no 937 0.270339213805036 301 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1553 gossypol 38.6 µM 0.611668814077074 0.278838703021241 no 938 0.2703784495591 295 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1387 3342-1166 1.8 µM 0.611010952256776 0.279053479205543 no 939 0.270596164835779 299 3418228
SGTC_1093 fluphenazine 7.97 µM 0.609402119166578 0.279579063503593 no 940 0.27112896679556 306 6602611 An atypical antipsychotic.
SGTC_1278 0874-0585 172 µM 0.609067760350878 0.279688354351829 no 941 0.271239763006096 293 766306
SGTC_1948 st076329 66.6 µM 0.608487999159358 0.279877908256615 no 942 0.271431931485574 299 24208413
SGTC_2536 dehydroabietamide 32.04 µM 0.608074239920863 0.280013225630296 no 943 0.271569118183574 300 3983547
SGTC_1067 clotrimazole 1.36 µM 0.607597983012309 0.280169021730088 no 944 0.271727069446685 278 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1854 st056233 32.9 µM 0.606631202222118 0.280485410137019 no 945 0.272047844194651 308 5393174
SGTC_163 TUB2.036 7.546 µM 0.604821833328696 0.281078007982077 no 946 0.272648692476042 299 15992207 YJR013W GPI14
SGTC_2293 7624732 200 µM 0.604598179622259 0.281151300203139 no 947 0.272723008253094 294 894453
SGTC_2933 9026794 32.47 µM 0.603248439205393 0.281593811410529 no 948 0.273171713993307 301 17586027
SGTC_2077 5212015 200 µM 0.601813967954436 0.282064469425864 no 949 0.273648988151357 297 780900
SGTC_996 3970-0799 1.8 µM 0.601252321893584 0.282248851767293 no 950 0.273835970134002 316 6615648 YGL040C HEM2
SGTC_3254 9136651 49.47 µM 0.599831806989406 0.28271545018194 no 951 0.274309166627035 325 16454030
SGTC_1381 2324-0066 62.1 µM 0.597701006631606 0.283416051177645 no 952 0.275019726834444 314 10885928
SGTC_3284 9108171 64.8615 µM 0.597600242628444 0.283449202689791 no 953 0.275053351151003 301 8687505
SGTC_1822 st052468 42 µM 0.596991023794749 0.283649676205181 no 954 0.275256686779499 303 2873678
SGTC_1984 st072354 53.1 µM 0.596372044871109 0.283853430972743 no 955 0.275463355732634 304 5762938
SGTC_1275 0867-0008 21.1 µM 0.596101916317319 0.283942373532891 no 956 0.275553572036863 300 3422836
SGTC_3113 9123498 49.47 µM 0.595628582995811 0.284098255470833 no 957 0.275711688773524 327 8897275
SGTC_2151 5563267 85.4165 µM 0.594017514483149 0.284629132050981 no 958 0.276250199317977 328 5310824
SGTC_2317 5986382 200 µM 0.593007032744864 0.284962345810786 no 959 0.276588222843261 337 877883
SGTC_1688 st021091 57.6 µM 0.592474445107801 0.285138045325016 no 960 0.276766464121476 317 3656366
SGTC_51 1013-0126 23.419 µM 0.592403439408663 0.285161473852597 no 961 0.276790231872429 310 1627850
SGTC_3086 9117350 49.47 µM 0.592158120028673 0.285242424722975 no 962 0.276872355367975 286 2679265
SGTC_1491 4138-0063 26.5 µM 0.590973283722007 0.285633552918897 no 963 0.277269160911205 314 23883227
SGTC_575 k072-0246 11.9 µM 0.590448527123917 0.2858068626606 no 964 0.277444992438414 296 6796779
SGTC_1 0258-0098 57.368 µM 0.590179369182767 0.285895776022511 no 965 0.277535201017581 271 6790032 YDR047W HEM12
SGTC_1163 k060-0048 49.9 µM 0.589091875999867 0.286255151260702 no 966 0.277899821429567 301 6809982
SGTC_1305 1181-0477 144 µM 0.583293689508625 0.288174843637699 no 967 0.279847804964335 319 6252086
SGTC_2394 5221648 200 µM 0.58291437954958 0.288300638829303 no 968 0.279975470010861 314 788586
SGTC_2140 5586273 200 µM 0.582866204754926 0.288316617477568 no 969 0.27999168631026 310 854421
SGTC_3353 9151644 39.2805 µM 0.581941997834197 0.288623239871672 no 970 0.280302875222129 317 4909158
SGTC_87 0100-0052 35.5 µM 0.581901455048982 0.288636694191569 no 971 0.280316530182605 319 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2409 alverine citrate 63.97 µM 0.581699425736612 0.288703743002172 no 972 0.280384579206636 277 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1610 st001799 48.1 µM 0.580356759053939 0.289149528959619 no 973 0.280837029347917 305 621897
SGTC_1572 epiandrosterone 68.9 µM 0.577907258335139 0.289963633600261 no 974 0.281663367317038 312 441302 A steroid.
SGTC_2314 7727897 200 µM 0.576465062768255 0.290443457121773 no 975 0.282150439049909 285 900724
SGTC_3111 9122088 49.47 µM 0.573393019791554 0.291466773762816 no 976 0.283189307723597 301 16876704
SGTC_652 0437-0092 114 µM 0.573045060206432 0.291582787218771 no 977 0.2833070923513 296 3091274
SGTC_425 3825-7017 13.1 µM 0.572700721010395 0.29169761478965 no 978 0.283423674597004 321 3397440
SGTC_3202 9113761 49.47 µM 0.571297575154053 0.292165742795056 no 979 0.283898972577128 313 4798415
SGTC_1842 st055362 61.2 µM 0.566162932975856 0.29388177355317 no 980 0.285641512597635 303 676032
SGTC_2204 7233102 200 µM 0.564021181535746 0.294598936008476 no 981 0.286369858461682 320 2172480
SGTC_2322 7413319 38.22 µM 0.563568277728356 0.29475069357152 no 982 0.286523990398714 309 1840400
SGTC_1219 1469-0211 33.1 µM 0.562616993390867 0.295069564207021 no 983 0.286847858969796 329 6822282
SGTC_584 0986-0246 15.4 µM 0.561966347917039 0.295287752113923 no 984 0.287069473694548 342 53315 YDR232W HEM1
SGTC_2846 9008642 19.48 µM 0.559888011221243 0.295985199889371 no 985 0.287777913347963 344 2992898
SGTC_1608 st001473 40.5 µM 0.558842990872888 0.296336173082087 no 986 0.288134439712154 352 7292267
SGTC_691 1548-0686 185 µM 0.557971140597927 0.296629132517052 no 987 0.288432045551911 319 46495133
SGTC_304 1310-0298 97 µM 0.557735299429235 0.296708402738654 no 988 0.28851257475759 338 1550234
SGTC_2801 7907800 81.82 µM 0.553860353621461 0.29801222440715 no 989 0.289837209956641 325 6620925
SGTC_2853 9015042 58.44 µM 0.553580967177367 0.298106331748052 no 990 0.289932827289281 288 6457456
SGTC_2035 5154463 94.595 µM 0.552549533681959 0.298453872615162 no 991 0.290285953562394 339 2769623
SGTC_1089 terbinafine 2.25 µM 0.552177885139126 0.298579144525544 no 992 0.290413242201867 334 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_138 0850-0259 40.9225 µM 0.552177211080598 0.298579371752787 no 993 0.290413473088861 313 6813004
SGTC_1033 k072-0102 21.3 µM 0.550337749206082 0.299199752841812 no 994 0.291043868533437 318 5965931
SGTC_2191 5911152 200 µM 0.549824881575297 0.299372827968249 no 995 0.291219745467926 316 2875902
SGTC_3114 9122766 49.47 µM 0.549550364518946 0.299465486652854 no 996 0.291313905576706 289 17176985
SGTC_2152 5568786 200 µM 0.54945588332721 0.299497380221088 no 997 0.291346316172836 335 5399883
SGTC_3335 9143315 29.6265 µM 0.548450330942811 0.299836915128035 no 998 0.29169136260231 308 4899691
SGTC_346 4513-0042 7.16 µM 0.547501906188444 0.300157319920125 no 999 0.292016980624189 317 2827372
SGTC_2751 anetholtrithion 17.25 µM 0.544890802220515 0.301040223755976 no 1000 0.292914311286885 332 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1211 1056-0033 32.3 µM 0.544496976119361 0.301173491404642 no 1001 0.293049764351003 300 6741922
SGTC_2761 levamisole 97.89 µM 0.544235725043796 0.301261911370903 no 1002 0.293139635415211 338 26879 An alkaline phosphatase inhibitor.
SGTC_347 4534-1311 26.2 µM 0.542552508876213 0.301831873011256 no 1003 0.293718972462682 315 2862016
SGTC_2068 5226020 147 µM 0.54238005134626 0.301890297016873 no 1004 0.29377835959863 327 1810509
SGTC_133 0724-0033 378.92 µM 0.541291007451972 0.30225935330437 no 1005 0.294153508865034 317 280309
SGTC_1737 st035557 69.7 µM 0.541074049150761 0.302332900527425 no 1006 0.294228272183936 329 5716916
SGTC_628 1636-0253 16 µM 0.540392901171974 0.302563856688781 no 1007 0.294463051193387 312 4456143
SGTC_2945 9067681 61.76 µM 0.540252631646669 0.302611427553271 no 1008 0.294511410218803 343 16456930
SGTC_3047 9092122 49.47 µM 0.540215606456974 0.302623984797637 no 1009 0.294524175556415 323 17173831
SGTC_1767 st044992 70.3 µM 0.535993574222692 0.304057432732192 no 1010 0.295981495725194 320 9600693
SGTC_1413 3910-0535 34.4 µM 0.535781958749689 0.304129359177399 no 1011 0.296054626146292 320 2876951
SGTC_1868 st057644 42.7 µM 0.535440373840936 0.304245477211175 no 1012 0.296172689111477 310 688665
SGTC_2541 muurolladie-3-one 83.07 µM 0.535253352500304 0.30430906142379 no 1013 0.296237338979588 339 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2913 7966556 36.57 µM 0.533608642967794 0.304868490535905 no 1014 0.296806163628356 314 2976516
SGTC_1011 4112-3381 17.4 µM 0.53188728601576 0.305454479307719 no 1015 0.297402031747461 338 2877139
SGTC_445 e6 berbamine 66 µM 0.531789443319708 0.30548780216549 no 1016 0.297435917562458 321 6610268 A calcium/calmodulin antagonist.
SGTC_1933 st074711 15.9 µM 0.531754744784553 0.30549962003512 no 1017 0.297447935113382 313 17250958
SGTC_3275 9138069 49.47 µM 0.529662997949321 0.306212415784778 no 1018 0.298172803559644 321 17617007
SGTC_1503 4585-0012 61.3 µM 0.529078848194341 0.306411605294593 no 1019 0.29837537691086 325 2922052
SGTC_331 k048-0133 24.5 µM 0.528249799694626 0.306694401167037 no 1020 0.298662984530609 317 6813582
SGTC_1818 st052136 56.3 µM 0.526988091531022 0.307125001992601 no 1021 0.299100929083277 317 674169
SGTC_1347 1493-0251 600 nM 0.526720298783652 0.307216429631019 no 1022 0.299193918635373 312 3986378
SGTC_3301 9125354 19.7965 µM 0.52534284127562 0.307686899324437 no 1023 0.299672440305106 308 41905162
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.52526993210578 0.307711810226868 no 1024 0.299697778235152 337 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1235 benzylparaben 21.5 µM 0.524759142978579 0.307886356588623 no 1025 0.299875318630902 354 7180
SGTC_2395 5646831 180.19 µM 0.523419678508208 0.308344283502718 no 1026 0.30034111647145 349 6808628
SGTC_1367 1812-0510 76.9 µM 0.517362390290277 0.310418825069053 no 1027 0.30245160436265 314 1142582 YDR527W RBA50
SGTC_546 peri-Naphthalide 147 µM 0.516525448104815 0.31070594358731 no 1028 0.302743734953781 310 223824 A penicillin ester.
SGTC_3308 9128332 17.569 µM 0.515425635175226 0.311083416972896 no 1029 0.303127811330434 315 17332805 YDL196W YDL196W
SGTC_2928 9011484 9.79 µM 0.513734024084251 0.311664392929655 no 1030 0.303718980276132 342 2994751
SGTC_1956 st077085 54 µM 0.513271850041634 0.311823206108969 no 1031 0.303880586128862 346 24208685
SGTC_2679 rapamycin 1 nM 0.508656645042185 0.313411007904226 no 1032 0.305496458319612 312 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_3084 9116877 49.47 µM 0.507258171185138 0.31389282010076 no 1033 0.305986841879905 331 27241325
SGTC_615 k087-0205 167 µM 0.506937012013736 0.314003513008948 no 1034 0.306099507502651 337 9642773
SGTC_2224 6650123 117.647 µM 0.506732372411707 0.31407405421947 no 1035 0.306171306546275 342 2908370
SGTC_2030 5175110 200 µM 0.506539735114075 0.314140464329576 no 1036 0.306238901312282 355 2831986
SGTC_894 0960-0238 55.9 µM 0.505480368149315 0.314505779805134 no 1037 0.306610741869023 338 6741907 YDL195W SEC31
SGTC_3287 9117173 37.0625 µM 0.504767861648755 0.314751585038801 no 1038 0.306860945547735 315 2789709
SGTC_1447 4239-0816 81.9 µM 0.504631554901635 0.314798618406581 no 1039 0.30690882126397 320 1341554
SGTC_981 1488-1094 54.9 µM 0.503189455939803 0.315296406231543 no 1040 0.307415538661608 330 3449522
SGTC_3159 9100096 49.47 µM 0.503021298702774 0.315354473083458 no 1041 0.307474648857683 312 25236875
SGTC_1739 st037196 92.5 µM 0.50175269934268 0.315792683636358 no 1042 0.307920744678155 355 612214
SGTC_2091 4-phenylthiadiazole 200 µM 0.501613834659857 0.315840667215906 no 1043 0.307969592919176 330 270010
SGTC_3338 9144300 39.5675 µM 0.501225076233042 0.31597501608264 no 1044 0.308106364038505 324 4901274
SGTC_2645 abamectin 100 µM 0.499334284158349 0.316628790789557 no 1045 0.308771953185187 311 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_3050 9093513 49.47 µM 0.499252801412996 0.316656977784482 no 1046 0.308800650562335 332 25236664
SGTC_1941 st076221 61.8 µM 0.499192430966566 0.316677862174262 no 1047 0.308821913159854 313 2828568
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.498511111113061 0.316913596629047 no 1048 0.309061919846867 323 688664
SGTC_1632 st005650 90 µM 0.498310986351919 0.316982853275927 no 1049 0.309132432745792 318 2759605
SGTC_3176 9106582 49.47 µM 0.496677481439499 0.317548395610668 no 1050 0.309708252315786 319 17018027
SGTC_2309 7664088 163.95 µM 0.495971358725035 0.317792997190825 no 1051 0.309957309250815 358 704922
SGTC_1183 1254-0324 198 µM 0.495951144562251 0.317800000567546 no 1052 0.309964440284294 315 5799357
SGTC_726 3448-4391 34.2 µM 0.49588900777352 0.317821528819497 no 1053 0.309986360982858 361 1356692
SGTC_746 1095-0025 46.6 µM 0.494792824631321 0.318201419637347 no 1054 0.310373184929573 349 6749286
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.494481960940887 0.318309186710418 no 1055 0.310482921525341 329 16623 A steroid.
SGTC_301 4119-0100 24.5 µM 0.49439830510321 0.318338190294725 no 1056 0.310512455378081 365 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2512 diallyl trisulfide 49.23 µM 0.494110452202643 0.318437997765301 no 1057 0.310614088283659 363 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_539 4859-0462 2.54 µM 0.49378104085717 0.318552230998988 no 1058 0.310730412065206 343 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_226 1,3-diallylurea 8.28947 mM 0.492065508799008 0.319147421667628 no 1059 0.311336517069828 328 74537 YKL182W FAS1
SGTC_2979 9012552 45.46 µM 0.491280702890673 0.319419859664288 no 1060 0.311613963164951 364 17100905
SGTC_1286 0929-0070 131 µM 0.490675979548609 0.319629850216426 no 1061 0.311827819114851 332 1420408
SGTC_2602 kawain 100 µM 0.489097648713136 0.320178198924552 no 1062 0.312386283013699 320 5369129
SGTC_2787 5284540 71.43 µM 0.487790861696721 0.320632504473093 no 1063 0.312848992437031 354 736958
SGTC_900 1112-0045 141 µM 0.487276126643303 0.320811526361454 no 1064 0.313031331750915 336 56211 YIL048W NEO1
SGTC_85 0868-0259 160.055 µM 0.486569421469189 0.32105738223637 no 1065 0.31328174890063 352 83173
SGTC_1643 st009866 20.2 µM 0.486331850031002 0.321140048663223 no 1066 0.313365950399728 319 3156273 YOR207C RET1
SGTC_1039 k821-0043 94 µM 0.486189773831115 0.321189490373144 no 1067 0.313416310550857 342 15992768
SGTC_1027 k015-0025 8.67 µM 0.486078403609738 0.321228248793198 no 1068 0.313455789131769 336 3598955
SGTC_823 0417-1665 178 µM 0.485976472549011 0.321263723957852 no 1069 0.313491923586713 364 3429856
SGTC_2428 5615643 7.78 µM 0.485926470754647 0.321281126726461 no 1070 0.313509649825201 372 2253075
SGTC_1363 1636-0063 10.4 µM 0.485884640471054 0.321295685760371 no 1071 0.313524479495552 344 6072185
SGTC_385 1494-0393 12.4 µM 0.484233715325757 0.321870509506541 no 1072 0.314110005900888 351 3090647
SGTC_2216 7189485 200 µM 0.483489827952315 0.322129657782024 no 1073 0.314373990294344 340 731273
SGTC_784 4579-0127 173 µM 0.481737431901326 0.322740482265698 no 1074 0.314996240774691 355 1948547
SGTC_734 2023-0417 80 µM 0.481654355201139 0.322769451816857 no 1075 0.315025753167766 367 3935732
SGTC_1012 4112-3522 18 µM 0.480247065521736 0.323260348999908 no 1076 0.315525861895787 338 3112398
SGTC_2568 diosmetin 100 µM 0.4792044396147 0.323624241126295 no 1077 0.31589659809398 361 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_788 1182-0090 188 µM 0.477535263663139 0.324207159799406 no 1078 0.316490508134669 324 5715185
SGTC_368 fentichlor 4.58 µM 0.477164585829672 0.324336668479317 no 1079 0.316622463443922 378 7329 A pesticide.
SGTC_1989 st071868 50.2 µM 0.477080849888874 0.32436592736989 no 1080 0.316652275316063 360 16414057
SGTC_2098 5376439 882.5 nM 0.473488748005536 0.325622093402695 no 1081 0.317932263369393 361 2844116
SGTC_2866 9034245 58.44 µM 0.472031240322462 0.326132353433144 no 1082 0.318452245050149 363 6462273
SGTC_3138 9097216 49.47 µM 0.471247485252827 0.326406873595169 no 1083 0.31873200618884 359 25237486
SGTC_1870 st057514 26.5 µM 0.470166836436791 0.326785538789429 no 1084 0.31911791291902 337 5393161
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.469979373171505 0.326851245108418 no 1085 0.31918487724379 339 688667
SGTC_907 3448-6986 75.5 µM 0.469707968546332 0.32694638258676 no 1086 0.319281836971693 362 590582
SGTC_332 4112-0506 40.9 µM 0.46863879364944 0.327321277797641 no 1087 0.319663921592485 365 2790355
SGTC_2376 9072922 81.32 µM 0.468604068572028 0.327333456713252 no 1088 0.319676334297696 340 17087968
SGTC_272 doxorubicin 8.13 µM 0.46780731330342 0.327612948319867 no 1089 0.319961195122658 353 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2741 miltefosine 3.04 µM 0.46686405439388 0.327943956442081 no 1090 0.320298572096361 351 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2213 7173844 200 µM 0.466688304660889 0.328005645433299 no 1091 0.320361449224584 349 892728
SGTC_2267 7931562 200 µM 0.465943176042618 0.328267241221825 no 1092 0.320628087538171 335 934880
SGTC_2953 9074162 66.49 µM 0.464983412038994 0.328604314172275 no 1093 0.320971667827178 363 16451992
SGTC_688 0527-0193 473 µM 0.464752906951201 0.328685289266505 no 1094 0.321054207841452 370 4007154
SGTC_3119 9125183 49.47 µM 0.462988627828755 0.329305336422565 no 1095 0.321686259277707 328 22695334
SGTC_1672 st016598 6.51 µM 0.46234190504517 0.329532741688563 no 1096 0.321918076590609 380 4665860 YNL267W PIK1
SGTC_1059 3448-6867 171 µM 0.460818892769531 0.330068523065305 no 1097 0.322464272965166 346 3934407
SGTC_223 busulfan 5 mM 0.458562593943032 0.330862908509301 no 1098 0.323274151737059 352 2478 A DNA alkylator.
SGTC_927 2425-1185 123 µM 0.458455418822393 0.330900661134177 no 1099 0.32331264219443 371 730375
SGTC_908 3448-7491 47.7 µM 0.458097353071225 0.331026802893814 no 1100 0.323441250252736 312 1203031
SGTC_2605 digitonin 300 nM 0.45767084321587 0.331177081625712 no 1101 0.323594469213024 348 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2353 9059630 146.67 µM 0.456337308750351 0.331647121548301 no 1102 0.324073719621687 361 4779114
SGTC_1594 piperine 70.1 µM 0.455315363745598 0.33200751296829 no 1103 0.32444118737394 351 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3072 9116419 49.47 µM 0.453960476605766 0.332485556910196 no 1104 0.324928637034684 338 17170162
SGTC_3258 9138477 49.47 µM 0.453236172064685 0.332741224671158 no 1105 0.325189344164762 366 4970355
SGTC_3154 9100113 49.47 µM 0.452449474674087 0.333019004240253 no 1106 0.32547260603304 356 25237525
SGTC_822 1487-0950 154 µM 0.452248532660692 0.333089970728095 no 1107 0.325544974309343 345 1958375
SGTC_2439 5492030 7.2 µM 0.45177224609946 0.33325820424325 no 1108 0.325716532833257 354 5722370
SGTC_296 1222-0039 74.9 µM 0.451266451948993 0.333436897138133 no 1109 0.325898760417048 329 5984176
SGTC_2166 5933061 31.504 µM 0.450886144929353 0.333571281367452 no 1110 0.326035804880157 352 2877375
SGTC_1384 3089-0840 101 µM 0.450690795363989 0.333640317849848 no 1111 0.326106208659088 330 1069836
SGTC_976 1348-1067 47.6 µM 0.449092153921374 0.334205488790419 no 1112 0.326682590097827 354 5310671 YGL099W LSG1
SGTC_946 3434-1334 87.4 µM 0.449080401309084 0.334209645109368 no 1113 0.326686828972229 347 4047976
SGTC_507 nimesulide 162 µM 0.448878084766255 0.334281197672553 no 1114 0.326759803015018 364 4495 A COX2 inhibitor.
SGTC_2252 omeprazole 400 µM 0.447637128102139 0.334720214014836 no 1115 0.327207551581406 353 4594 A proton pump inhibitor.
SGTC_2032 5185112 25.99 µM 0.447509173800082 0.334765493592387 no 1116 0.327253732827571 345 5718189
SGTC_502 l-744,832 89.3 µM 0.44713512316081 0.334897873804236 no 1117 0.327388750286738 385 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2492 derrusnin 100 µM 0.446922983446195 0.334972961261381 no 1118 0.327465334354838 396 1715307 Part of coumarin class of compounds.
SGTC_2198 6589944 200 µM 0.443660480481644 0.336128562786758 no 1119 0.328644035878936 338 5290268
SGTC_1132 3456-3614 2.5 µM 0.442658474051278 0.336483792245383 no 1120 0.329006391450339 354 3125502
SGTC_1686 st019653 115.5 µM 0.441760081915932 0.33680241270257 no 1121 0.329331413675887 377 97252
SGTC_1629 st005085 44.9 µM 0.441580288749052 0.336866191564476 no 1122 0.329396475132315 359 24207091
SGTC_1362 1611-0397 101 µM 0.439969441153798 0.337437824094894 no 1123 0.329979620159167 345 27816
SGTC_194 1486-1323 56.904 µM 0.439043416129934 0.337766607460832 no 1124 0.33031503890723 362 5178754
SGTC_1545 lovastatin 49.4 µM 0.438576098395191 0.337932574737733 no 1125 0.33048435949016 336 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1146 3579-1023 7 µM 0.437310939300481 0.338382052375728 no 1126 0.330942931488643 368 X1146
SGTC_2340 7987427 183.45 µM 0.436839280000034 0.338549679465935 no 1127 0.331113954999496 343 2239331
SGTC_250 brefeldin a 552.239 µM 0.436137814171127 0.338799038655114 no 1128 0.331368371454558 372 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_941 3237-0776 460 µM 0.43557864719948 0.338997863640193 no 1129 0.331571232934886 378 760008
SGTC_866 0495-0101 262 µM 0.435167435336791 0.33914410832768 no 1130 0.331720448973773 365 635694
SGTC_681 1642-0006 26.6 µM 0.43457030360025 0.339356517297914 no 1131 0.331937177110337 385 4446530
SGTC_220 paclitaxel 373.376 µM 0.434503519518768 0.339380276601294 no 1132 0.331961419798524 372 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_542 3381-0244 89.3 µM 0.432769033258103 0.339997565989557 no 1133 0.332591286177537 391 1112843
SGTC_980 1473-0395 201 µM 0.43189633348428 0.34030831506877 no 1134 0.332908379860934 372 768876
SGTC_2256 7954252 200 µM 0.431306933080447 0.340518248895539 no 1135 0.333122604938269 385 2972920
SGTC_1412 3909-8563 178 µM 0.430703945808796 0.340733073266282 no 1136 0.333341824698528 378 23767530
SGTC_2797 7859098 81.82 µM 0.42880910772844 0.341408477245023 no 1137 0.334031075130629 347 972681
SGTC_1802 st050112 57.9 µM 0.427249858088202 0.341964644006559 no 1138 0.334598675019564 358 4662563
SGTC_1342 1486-1464 234 µM 0.426771501078086 0.342135337388887 no 1139 0.334772882975659 365 3253938
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.426321918803915 0.342295792419193 no 1140 0.334936644178103 408 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2911 7942208 15.64 µM 0.426235072314027 0.342326791043037 no 1141 0.334968281796391 339 1243384
SGTC_1707 st032323 6.317 µM 0.426198535711609 0.342339832582987 no 1142 0.334981592195916 347 3132057 YMR211W DML1
SGTC_2262 9014885 67.46 µM 0.425338816667079 0.342646758813784 no 1143 0.335294850343171 372 6457424
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.424872645798965 0.342813228817929 no 1144 0.335464758197155 379 5024745
SGTC_191 3914-0123 66.505 µM 0.423367053974305 0.343351085262254 no 1145 0.336013739236753 378 3144412
SGTC_1407 3909-7909 12.3 µM 0.42248982038822 0.343664613926825 no 1146 0.336333764683149 362 4411780
SGTC_1579 chlormadinone acetate 49.4 µM 0.420619412759037 0.344333468058664 no 1147 0.337016507929976 393 45114258 A steroidal progestin.
SGTC_17 0960-0276 49.807 µM 0.420306061419652 0.344445569586609 no 1148 0.337130941222806 363 6821114
SGTC_478 N-arachidonylglycine 10 µM 0.419508571331648 0.344730933511257 no 1149 0.337422245915564 348 5283389
SGTC_2511 berberine 10.47 µM 0.419190178508278 0.344844887926768 no 1150 0.337538574688104 353 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_620 0109-0052 432 µM 0.417369578001717 0.345496760231156 no 1151 0.338204051636281 368 493037
SGTC_127 0180-0333 59.125 µM 0.416825094095246 0.345691803727637 no 1152 0.338403173048061 341 771601
SGTC_817 1391-0715 46 µM 0.416737932171104 0.345723030432537 no 1153 0.338435052945521 398 1353946
SGTC_2784 7567673 72.73 µM 0.416618428676963 0.345765845561797 no 1154 0.338478763811645 369 3471247
SGTC_1434 4073-0095 163 µM 0.415419768457293 0.346195404742184 no 1155 0.338917318798049 378 24133745
SGTC_1094 duloxetine 25.4 µM 0.415203820522402 0.346272814219586 no 1156 0.338996351116121 336 60834 A selective serotonin reuptake inhibitor.
SGTC_2777 climbazole 1.536 µM 0.415020321146792 0.346338597116659 no 1157 0.339063513526037 358 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_3215 9129942 49.47 µM 0.415011733115388 0.346341675963242 no 1158 0.339066656947524 397 17682944
SGTC_960 1222-0186 7.7 µM 0.414174175810669 0.346641992651377 no 1159 0.339373276417889 378 3126296
SGTC_1907 st060210 83.7 µM 0.413384927726232 0.346925075690807 no 1160 0.339662307833552 389 688793
SGTC_459 nigericin 15.3 µM 0.411663661185402 0.347542746091675 no 1161 0.340292981700221 387 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_3126 9127922 49.47 µM 0.410512504625969 0.347956060657777 no 1162 0.340715016229991 407 45595682
SGTC_601 0986-0029 62.9 µM 0.409171586661022 0.34843773554183 no 1163 0.341206872165765 385 24747981
SGTC_2207 7258803 200 µM 0.408719277161486 0.348600266085692 no 1164 0.341372842648143 384 3666799
SGTC_335 4077-0256 27.6 µM 0.407492728556991 0.349041147492577 no 1165 0.341823066834807 381 3121989
SGTC_2210 7115885 190.385 µM 0.407000357696593 0.34921818697466 no 1166 0.342003862739879 383 2927039
SGTC_2564 betulinic acid 100 µM 0.404670240875468 0.350056460714286 no 1167 0.342859959849803 363 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2894 9048625 32.47 µM 0.403660707944022 0.35041987361961 no 1168 0.343231118509247 410 4092861
SGTC_2 0422-0095 29 µM 0.403328145948398 0.350539619703986 no 1169 0.343353419345742 344 6790840
SGTC_1949 st076024 69.1 µM 0.403042505985716 0.350642482361799 no 1170 0.343458477537772 382 2921930
SGTC_219 mitoxanthrone 164.414 µM 0.402399546807889 0.350874060365317 no 1171 0.343695001748819 369 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1202 1988-0068 29.6 µM 0.401874169883862 0.351063329287846 no 1172 0.343888316633499 358 2850480
SGTC_3150 9097574 49.47 µM 0.399331012515256 0.351980032495464 no 1173 0.344824659452541 397 17217476
SGTC_581 0958-0271 211 µM 0.397641377932899 0.352589552398476 no 1174 0.345447277536788 350 4591145
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.397349982716355 0.352694708829425 no 1175 0.34555469690834 348 66535 A nucleotide analog.
SGTC_2375 9072683 200 µM 0.397047506456128 0.352803876007436 no 1176 0.345666214331257 397 16798029
SGTC_800 3448-7362 155 µM 0.396526927944681 0.352991787185115 no 1177 0.345858173392118 374 15991913
SGTC_392 N-ethylmaleimide 8.33 µM 0.396055978678231 0.353161814786063 no 1178 0.346031866218707 350 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_472 calcifediol 10 µM 0.394288286731127 0.353800268864732 no 1179 0.346684105075523 368 5283731 A vitamin D metabolite.
SGTC_1320 1313-0481 95.3 µM 0.394254991216756 0.353812298474576 no 1180 0.346696394745724 370 6813365 YLR208W SEC13
SGTC_198 3454-2873 16.191 µM 0.392932850686698 0.354290103346157 no 1181 0.347184538838233 379 710957
SGTC_2214 7179297 48.276 µM 0.392255613974953 0.354534937049614 no 1182 0.347434677946173 378 769744
SGTC_612 0302-0167 22.4 µM 0.391138174221325 0.354939043751595 no 1183 0.347847552419307 392 235821
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.389742860856102 0.355443868774407 no 1184 0.348363349690383 381 4620898
SGTC_1861 st057647 17.4 µM 0.38912799523444 0.355666408035359 no 1185 0.348590732553795 419 688668
SGTC_1616 st002734 56.1 µM 0.388966288336323 0.355724943036891 no 1186 0.348650542265583 388 4026101
SGTC_1803 st050068 52.4 µM 0.387869523211473 0.356122042098902 no 1187 0.349056296450364 388 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_625 k213-0058 121 µM 0.387349187336185 0.356310491562529 no 1188 0.349248857928202 372 3655420
SGTC_1705 st027868 56.3335 µM 0.387296301659157 0.356329647074754 no 1189 0.349268431583783 413 292948
SGTC_2243 6634756 200 µM 0.387278654493965 0.356336039065434 no 1190 0.349274963111239 336 885676
SGTC_2421 5690543 90.72 µM 0.386257682347924 0.356705914687217 no 1191 0.349652918873813 396 3397993
SGTC_318 1488-0629 67.2 µM 0.385832741832681 0.356859900977584 no 1192 0.349810272426657 402 3662576
SGTC_2927 9011802 47.9 µM 0.385596116194603 0.356945657454461 no 1193 0.349897905016641 368 43912568
SGTC_2362 9071156 126 µM 0.385388294721032 0.357020980857656 no 1194 0.349974876788549 370 653133
SGTC_2021 4019055 173 µM 0.384058981030474 0.357502912806172 no 1195 0.350467366382418 361 44827708 YER133W GLC7
SGTC_1104 tacrolimus 29.8 µM 0.382845235994659 0.357943144843185 no 1196 0.350917259295861 382 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2744 captopril 92.04 µM 0.382449523525011 0.358086712824259 no 1197 0.351063981321326 369 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1756 st041558 35.5 µM 0.382428548665314 0.358094323249011 no 1198 0.351071758986772 391 3955792
SGTC_1262 0737-0114 49.6 µM 0.382125858848716 0.358204156152115 no 1199 0.351184006021191 408 765919
SGTC_2693 st077581 40.7 µM 0.382026838880799 0.3582400887178 no 1200 0.351220728601171 405 25238761
SGTC_1285 0929-0069 65.5 µM 0.381761451336954 0.358336399276051 no 1201 0.35131915716872 362 1206237
SGTC_1663 st014140 55.4 µM 0.380158769515564 0.358918212445956 no 1202 0.351913781432055 380 4207120
SGTC_1993 st073995 70.8 µM 0.379083538745284 0.35930873145666 no 1203 0.35231291491425 373 3098394
SGTC_2082 5219693 150 µM 0.376640633683406 0.360196529568872 no 1204 0.353220343241478 376 2834649
SGTC_1662 st014054 52 µM 0.376572977537448 0.360221127856367 no 1205 0.353245486336912 393 2838777
SGTC_1745 st081495 74 µM 0.376411787468484 0.360279735353831 no 1206 0.353305392083093 372 13842402 YBL026W LSM2
SGTC_1224 0823-0416 294 µM 0.375920042723438 0.360458550329669 no 1207 0.35348816981434 387 3598164
SGTC_755 1995-0008 37.3 µM 0.375297575600896 0.360684944140073 no 1208 0.353719584499718 365 689533
SGTC_664 1222-0054 14.9 µM 0.37462364151566 0.360930111751296 no 1209 0.353970194019899 369 6813991
SGTC_151 3013-0144 2.285 µM 0.374207583362989 0.361081496315013 no 1210 0.354124941244355 411 906558 YHR107C CDC12
SGTC_410 α-linolenic acid 100 µM 0.373042190725874 0.361505645259155 no 1211 0.354558521527562 402 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2971 9092186 9.93 µM 0.372856010600869 0.361573421987095 no 1212 0.354627806675573 325 25236400
SGTC_2611 pyromycin 23.93 µM 0.370759143234645 0.362337061859372 no 1213 0.355408467406001 357 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1186 1319-0216 26 µM 0.369927352140529 0.362640136631076 no 1214 0.35571831040113 379 4565136
SGTC_1055 3448-0672 86 µM 0.369045713690271 0.36296146796486 no 1215 0.356046825677894 380 748378
SGTC_1887 st057648 70.8 µM 0.368752053705467 0.363068519845214 no 1216 0.356156272726102 402 688672
SGTC_649 1123-0311 367 µM 0.367992759811237 0.363345365186014 no 1217 0.356439316410022 391 693629 YIL048W NEO1
SGTC_13 0199-0087 65 µM 0.366257010140564 0.363978502985746 no 1218 0.357086652554934 384 4589825
SGTC_3231 9132313 49.47 µM 0.364269220575237 0.364704031973786 no 1219 0.357828490845049 392 4905967
SGTC_2313 7726885 200 µM 0.363524474604399 0.36497598392529 no 1220 0.358106566765178 359 726423
SGTC_2788 5282734 71.43 µM 0.363240822824242 0.365079580276938 no 1221 0.358212497490825 398 743706
SGTC_112 phenothiazine 287.218 µM 0.361415376945194 0.365746511696636 no 1222 0.358894477314709 417 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1113 artemisinin 1.17947 µM 0.360703857072996 0.366006577416358 no 1223 0.35916042052001 399 2240 An anti-malaria and mitochondrial poison.
SGTC_451 chloral hydrate 100 µM 0.359007796919966 0.366626747943592 no 1224 0.359794628241793 398 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_632 0781-2353 4.65 µM 0.357816403886573 0.36706259352413 no 1225 0.360240356872789 397 6811515 YHR007C ERG11
SGTC_2469 5655019 90.81 µM 0.356630532644178 0.367496589282162 no 1226 0.360684208405892 416 2788239
SGTC_2502 avocadyne acetate 18.59 µM 0.356318078489286 0.367610966978347 no 1227 0.36080118598116 355 3952079
SGTC_580 1123-0028 41 µM 0.356230135260586 0.367643161799898 no 1228 0.360834112794625 402 1677248 YPR107C YTH1
SGTC_2858 9025781 8.96 µM 0.355132364353924 0.368045119022622 no 1229 0.361245215798779 389 4894980 YPL153C RAD53
SGTC_3204 9114183 49.47 µM 0.354395679230696 0.368314942982972 no 1230 0.361521186098752 361 17027248
SGTC_2272 7805186 180 µM 0.352717491267003 0.368929851376419 no 1231 0.362150122494461 434 2956062 YPR165W RHO1
SGTC_3000 9075062 71.4286 µM 0.352674753491381 0.368945515404187 no 1232 0.362166144247976 372 17057871
SGTC_2757 clomiphene 4.22 µM 0.352346210140032 0.369065938675423 no 1233 0.362289318303391 433 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_56 0957-0365 83.25 µM 0.351468376858764 0.369387760010692 no 1234 0.362618496342927 382 6752360
SGTC_2948 9070189 9.45 µM 0.349653813224483 0.370053284836318 no 1235 0.363299259937734 395 6473636 YDL196W YDL196W
SGTC_3318 9139014 38.6185 µM 0.347695320269112 0.370772035238117 no 1236 0.364034505767681 406 16643984
SGTC_212 3807-4682 38.772 µM 0.347547788423334 0.37082619648641 no 1237 0.36408991161578 392 3125501 YBL034C STU1
SGTC_2033 5192550 145 µM 0.345696756088721 0.371505956602197 no 1238 0.364785311200588 368 182073
SGTC_379 3970-0972 5.9 µM 0.343716395377563 0.372233654269689 no 1239 0.365529789940541 376 2898042 YBL034C STU1
SGTC_2912 7964298 10.93 µM 0.343201740772079 0.372422842611194 no 1240 0.365723347589985 391 2975850
SGTC_58 0957-0393 9 µM 0.342725794408199 0.372597829109889 no 1241 0.365902377798183 381 6997992
SGTC_1613 st002381 52.1 µM 0.342415622251823 0.372711881199836 no 1242 0.366019066719835 378 551167
SGTC_655 k060-0012 42 µM 0.341608389790502 0.373008757524926 no 1243 0.366322811259973 421 5994525
SGTC_666 0272-0154 136 µM 0.341189093652462 0.373162992071054 no 1244 0.366480616616604 387 6870312
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.339419355619872 0.373814198966597 no 1245 0.367146919721314 365 6708561
SGTC_2907 7721985 69.9 µM 0.338880076341359 0.374012708187837 no 1246 0.367350037046733 373 3267881
SGTC_2773 thioridazine 9.09 µM 0.338877661528018 0.374013597158141 no 1247 0.367350946659788 401 5452 An antipsychotic.
SGTC_3345 9148410 3.559 µM 0.338869917430571 0.374016448013509 no 1248 0.367353863715173 408 4903596
SGTC_3105 9121040 49.47 µM 0.338244086856019 0.374246859469088 no 1249 0.367589627576684 385 41448907
SGTC_2161 5662504 8.5105 µM 0.337993434908841 0.374339154365786 no 1250 0.367684067568772 366 2859334
SGTC_169 k015-0017 16.025 µM 0.336338998535868 0.374948530265877 no 1251 0.368307622277943 414 1840002
SGTC_1836 st055642 81 µM 0.334741855523982 0.375537099716255 no 1252 0.368909912471302 424 8571
SGTC_3038 9091290 49.47 µM 0.334731117203922 0.375541057919045 no 1253 0.368913963034234 432 25236843
SGTC_2249 haloperidol 116.36 µM 0.334619691697921 0.375582130735717 no 1254 0.368955994306256 407 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_680 0417-1641 114 µM 0.333377944075857 0.376039949555086 no 1255 0.369424504960938 391 2835990
SGTC_2898 9056270 58.44 µM 0.332309707294874 0.376433936489532 no 1256 0.369827705324463 397 19154699
SGTC_1469 k284-2957 126 µM 0.331630365430139 0.376684558270127 no 1257 0.370084193837644 385 23884841
SGTC_924 2046-0044 21.3 µM 0.331217437914906 0.376836920276666 no 1258 0.37024012468594 381 3623589
SGTC_1896 st058441 89 µM 0.33069383195371 0.377030148002134 no 1259 0.370437880905833 370 688759
SGTC_902 1120-0002 2.07 µM 0.330638379453858 0.377050613592765 no 1260 0.370458826288529 386 3280475
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.329972117506757 0.377296534714459 no 1261 0.370710515132619 437 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_317 4495-0002 170 µM 0.328721900870691 0.37775813111821 no 1262 0.371182949487888 393 15991618
SGTC_885 0865-0106 16.8 µM 0.328234168206282 0.377938255809682 no 1263 0.371367307573767 391 2793380
SGTC_106 0092-0003 11.579 µM 0.327083777392077 0.378363212034413 no 1264 0.371802260677779 409 1072148
SGTC_774 k060-0086 136 µM 0.32575090753138 0.378855760322352 no 1265 0.372306412242471 418 5911235
SGTC_2507 purpurin 79.67 µM 0.325600364659599 0.378911404269635 no 1266 0.372363368129813 381 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1155 4088-0394 48.2 µM 0.325467131311878 0.378960652330648 no 1267 0.372413777518472 395 2326248
SGTC_1005 4092-0690 4.4 µM 0.325298330247458 0.379023050380515 no 1268 0.372477647239064 399 1529343
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.325272257911976 0.379032688414186 no 1269 0.372487512612708 428 442882
SGTC_2842 9000675 19.48 µM 0.324888305828381 0.379174630822461 no 1270 0.372632803903454 408 2989072
SGTC_3197 9113331 49.47 µM 0.322411581656676 0.380090636300423 no 1271 0.373570455701294 361 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_3289 9119912 71.43 µM 0.321062772963182 0.380589770636028 no 1272 0.374081410446881 402 17014829
SGTC_3286 9117135 37.221 µM 0.31974793342871 0.381076525901878 no 1273 0.374579710054141 420 3438150
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.319541799762945 0.381152853934349 no 1274 0.374657849880398 438 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3285 9112818 20.8695 µM 0.319510782092928 0.381164339686719 no 1275 0.374669608305153 418 17017947 YPR165W RHO1
SGTC_3314 9135860 59.4275 µM 0.317740343441118 0.381820101159497 no 1276 0.375340953092177 409 25252478
SGTC_1612 st002233 45.4 µM 0.317484032139968 0.381915065719862 no 1277 0.37543817688263 426 1035021
SGTC_2149 5554786 194.827 µM 0.317107019364471 0.382054763664515 no 1278 0.375581199432649 394 745063 YPR165W RHO1
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.317102641711905 0.38205638584584 no 1279 0.375582860227589 378 6708739 YPR165W RHO1
SGTC_3083 9117465 49.47 µM 0.317000752895669 0.382094142312978 no 1280 0.375621515483722 417 16420915
SGTC_2730 imipramine 71.33 µM 0.315546599435354 0.382633123270448 no 1281 0.376173337778366 372 3696 A tricyclic antidepressant.
SGTC_156 3474-0145 5.642 µM 0.315317336637874 0.382718120144248 no 1282 0.376260361586195 404 2265471
SGTC_888 0916-0002 6.97 µM 0.314998083863265 0.382836489305503 no 1283 0.376381554360959 390 2802138 YIL048W NEO1
SGTC_2111 5486399 200 µM 0.314899136289853 0.382873178260468 no 1284 0.37641911870491 393 689674
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.314753036549606 0.382927352776579 no 1285 0.376474585983642 405 688751
SGTC_2867 9039098 71.43 µM 0.314527863184976 0.383010852673694 no 1286 0.376560078835935 406 6463460
SGTC_2592 piperlongumine 83.33 µM 0.312893601975803 0.383617040160647 no 1287 0.377180749292904 406 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1769 st044406 64.4 µM 0.311725416824863 0.384050523369832 no 1288 0.377624604975818 439 670903
SGTC_371 0195-0006 7.36 µM 0.309645082480904 0.384822840442071 no 1289 0.378415434593786 389 3928593
SGTC_1862 st057513 3.81 µM 0.309624625475081 0.38483043731133 no 1290 0.378423213766536 405 5393163
SGTC_2575 plumbagin 510 nM 0.309613474116688 0.384834578474188 no 1291 0.378427454307336 397 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.308976827208879 0.385071025123232 no 1292 0.37866957707537 428 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_855 0428-0020 25 µM 0.305587747624865 0.386330425255537 no 1293 0.379959275235646 398 6812414
SGTC_1991 st073000 8.92 µM 0.305496945725879 0.386364184271369 no 1294 0.379993847909707 426 4301969 YIL048W NEO1
SGTC_1299 1079-1439 3.74 µM 0.305241471878541 0.386459170881923 no 1295 0.380091124302138 407 323161
SGTC_1563 conessine 56.1 µM 0.304953664491726 0.386566187433853 no 1296 0.3802007213744 421 441082 An anti-amoebic, histamine inhibitor.
SGTC_3325 9138760 55.175 µM 0.304443562790446 0.38675588174614 no 1297 0.380394991764969 383 43844959
SGTC_3243 9134147 49.47 µM 0.304347125570505 0.386791747425765 no 1298 0.38043172292455 417 24282180
SGTC_2918 7977171 22.06 µM 0.303699231628363 0.38703272878779 no 1299 0.380678521721588 403 2236483
SGTC_2058 5236698 133 µM 0.30238627259926 0.387521211708815 no 1300 0.381178809063181 386 766665
SGTC_1531 st059297 52.4 µM 0.300960084177844 0.388052023129297 no 1301 0.381722466187277 393 7566702
SGTC_1032 k061-1018 98.7 µM 0.299657663116014 0.388536952529145 no 1302 0.382219147629547 409 4005393
SGTC_928 2764-0428 58.7 µM 0.299240945500084 0.38869214539875 no 1303 0.382378104884558 407 662578
SGTC_1635 st007035 42.4 µM 0.297523381804022 0.389331983185701 no 1304 0.383033479829535 388 3716403
SGTC_508 roscovitine 141 µM 0.295362574471572 0.390137367099332 no 1305 0.383858459930145 427 160355 A CDKinase inhibitor.
SGTC_1149 3909-7961 23.3 µM 0.29482318976549 0.390338482233735 no 1306 0.384064475265177 404 735261
SGTC_1978 st071761 42 µM 0.294363045908628 0.390510074803438 no 1307 0.384240250847171 397 5147680
SGTC_1389 3405-0187 19 µM 0.293532474273494 0.390819857828729 no 1308 0.384557590600967 423 799890
SGTC_1138 3761-0006 1.03 µM 0.293217961274627 0.390937181630506 no 1309 0.384677778021356 422 12061087
SGTC_2674 ligustilide 100 µM 0.293153605941167 0.390961189532625 no 1310 0.384702372016848 417 5319022 A signalling regulator.
SGTC_2843 9000894 45.46 µM 0.292970566837118 0.391029474954221 no 1311 0.38477232466692 381 2242070
SGTC_158 k038-0087 26.446 µM 0.290991533576218 0.39176799644952 no 1312 0.385528897347239 403 X158
SGTC_829 1635-0120 117 µM 0.289713634899275 0.392245081047734 no 1313 0.386017662171682 403 285054
SGTC_607 4491-0986 66.8 µM 0.289575051109482 0.392296829009397 no 1314 0.386070677954938 405 698981 YDR232W HEM1
SGTC_2725 haloperidol 53.21 µM 0.2892207218855 0.392429146180357 no 1315 0.386206237689118 427 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1455 4262-0120 131 µM 0.288959901265597 0.392526552378301 no 1316 0.38630603165816 394 1529587
SGTC_2955 9076254 12.21 µM 0.287987558778875 0.392889743175115 no 1317 0.386678131041913 417 16459619
SGTC_426 0988-0037 14.6 µM 0.287903007692323 0.392921329233676 no 1318 0.386710492273477 449 5383008
SGTC_2333 9017922 200 µM 0.287837768984986 0.392945701178024 no 1319 0.38673546238948 410 3163164
SGTC_2521 angolensin 13.4 µM 0.287775040376404 0.392969135792824 no 1320 0.38675947220734 415 821428 A flavenoid.
SGTC_723 4182-0001 115 µM 0.286260592093887 0.393535032065714 no 1321 0.387339269326239 426 744821 YLR208W SEC13
SGTC_1096 rimcazole 32.2 µM 0.285568940630286 0.393793552893147 no 1322 0.387604147496417 439 18528119 A dopamine reuptake inhibitor.
SGTC_1129 3453-1384 223 µM 0.285197592993211 0.393932372035103 no 1323 0.387746382167679 437 1084452
SGTC_1226 3909-7979 35.4 µM 0.284546984698525 0.394175618360087 no 1324 0.387995616389287 426 6615510
SGTC_311 1315-0136 58 µM 0.281544276427724 0.395298790130287 no 1325 0.389146486581471 422 6759207
SGTC_2991 9074669 71.4286 µM 0.280704012125977 0.395613249696309 no 1326 0.389468715601397 447 17333109
SGTC_3123 9126162 49.47 µM 0.277522410754528 0.396804542890696 no 1327 0.390689500036172 384 25239884
SGTC_93 0109-0045 59.227 µM 0.276730458980973 0.397101225171568 no 1328 0.390993540990405 431 88733
SGTC_377 3970-0964 33.1 µM 0.276687552629944 0.397117300521873 no 1329 0.391010015221156 405 16481235
SGTC_3066 9117245 49.47 µM 0.276214168799465 0.397294670731603 no 1330 0.391191787640112 433 17176980
SGTC_1807 st050092 58.9 µM 0.276123356058008 0.397328699407722 no 1331 0.391226661113801 431 5008496
SGTC_2240 6690706 185.951 µM 0.272166762837581 0.398812039974715 no 1332 0.392746898448407 385 805876
SGTC_1856 st057054 55.7 µM 0.27191557852096 0.398906259451561 no 1333 0.392843466239869 435 1266018
SGTC_1107 amlodipine 47 µM 0.271124828482246 0.399202908985385 no 1334 0.393147513072227 412 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_714 4296-0578 26.1 µM 0.271039031816674 0.399235099071262 no 1335 0.393180506187217 423 1589775
SGTC_2110 5483698 200 µM 0.270772299541129 0.399335178837545 no 1336 0.393283083005673 392 2848765 YHR062C RPP1
SGTC_2155 5570423 76 µM 0.270494388359552 0.399439460043135 no 1337 0.393389966759632 430 797402
SGTC_460 trequinsin 123 µM 0.270339943204507 0.399497415930331 no 1338 0.393449369347599 426 5537 A vasodilator.
SGTC_1642 st009582 77.7 µM 0.269328751234609 0.399876922624885 no 1339 0.393838354518581 441 6739311
SGTC_1962 st076595 64.5 µM 0.265381353851562 0.401359307871819 no 1340 0.395357849412921 412 279619
SGTC_767 0929-0023 86 µM 0.264863445583068 0.401553906368481 no 1341 0.39555732954678 419 1204563
SGTC_2818 7996756 12.99 µM 0.264292255879018 0.401768553107389 no 1342 0.395777363555686 448 2241621
SGTC_139 0099-0334 718.624 µM 0.263802216066936 0.401952728242139 no 1343 0.395966163436613 414 97690
SGTC_1026 k007-1105 30.6 µM 0.263188844933618 0.402183286541718 no 1344 0.396202514131038 396 7066794
SGTC_24 0417-1663 219 µM 0.263138408795777 0.402202246351112 no 1345 0.396221950419503 430 4329390
SGTC_2367 9070478 135.38 µM 0.261994920976913 0.402632164701661 no 1346 0.396662678968256 428 572802
SGTC_1248 0469-0687 58.6 µM 0.261740504015335 0.402727834156714 no 1347 0.396760755549716 420 4017482
SGTC_1190 1486-1332 13 µM 0.259711164278564 0.403491143186154 no 1348 0.397543290113868 446 4150046
SGTC_1677 st019204 53.9 µM 0.25696511978221 0.404524616209628 no 1349 0.398602849753003 392 3945625
SGTC_1406 3909-7906 11.9 µM 0.256444932687322 0.404720463771377 no 1350 0.398803648122097 441 X1406
SGTC_134 0269-0018 6.916 µM 0.255793420429694 0.40496578819713 no 1351 0.399055177336849 425 4378915
SGTC_2695 st077686 51.995 µM 0.255708890265128 0.404997620443936 no 1352 0.399087814956091 400 2876092
SGTC_1137 ixabepilone 100 µM 0.255032467300627 0.4052523694474 no 1353 0.399349011437044 419 154225 A novel microtubule stabilizer.
SGTC_3162 9099653 49.47 µM 0.254984875552987 0.405270294583492 no 1354 0.399367390389705 426 25237511
SGTC_1620 st003704 16.5 µM 0.254153454710796 0.40558347610502 no 1355 0.39968850394174 441 2834414
SGTC_2413 inermin 26.06 µM 0.253293125687705 0.405907610466585 no 1356 0.400020853926627 460 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1934 st074720 32.6 µM 0.249461767980038 0.407351878963086 no 1357 0.401501805471132 413 17250992
SGTC_738 1315-0003 72.4 µM 0.249041789120566 0.407510271189086 no 1358 0.401664228238453 452 6251474
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.248837207396344 0.407587433300928 no 1359 0.401743354399455 412 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_288 1315-0019 35.1 µM 0.245789140436922 0.408737496136825 no 1360 0.402922731957663 442 6811474
SGTC_916 4466-0038 42 nM 0.244207535357724 0.409334560313986 no 1361 0.403535045673848 457 5722064 YGL116W CDC20
SGTC_549 1661-1316 519 µM 0.24294733428597 0.409810443466032 no 1362 0.404023098177318 451 2857282
SGTC_2775 cyproheptadine 69.59 µM 0.240391027361963 0.410776175789234 no 1363 0.40501356671548 459 2913 A selective serotonin reuptake inhibitor.
SGTC_978 1416-0512 87.4 µM 0.239198281046651 0.411226961986222 no 1364 0.405475917754827 430 6814003
SGTC_3264 9137442 49.47 µM 0.237783528281762 0.411761805195791 no 1365 0.406024497415413 410 17015726
SGTC_1103 duloxetine 36.1 µM 0.237373131242604 0.411916985342144 no 1366 0.406183666141206 434 60835 A selective serotonin reuptake inhibitor.
SGTC_904 1141-0088 396 µM 0.236297313251838 0.412323841113242 no 1367 0.406600985815395 439 1378119
SGTC_877 0771-0151 33.1 µM 0.235759266370945 0.412527356524046 no 1368 0.406809738969726 448 6166523
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.234808964320998 0.412886864244907 no 1369 0.407178504862272 410 641818 YHR062C RPP1
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.234324150262019 0.413070301886506 no 1370 0.407366669282543 448 756377
SGTC_2540 epiandrosterone 100 µM 0.233598179364419 0.413345020798186 no 1371 0.407648470652467 436 441302 A steroid.
SGTC_1832 st054113 55 µM 0.232811749885226 0.413642666071694 no 1372 0.407953794258966 452 1251267
SGTC_1237 0330-0133 46.1 µM 0.232232070257817 0.413862093114551 no 1373 0.408178885045969 450 X1237 YHR072W ERG7
SGTC_383 2324-0395 7.37 µM 0.231323248478316 0.414206164971199 no 1374 0.408531843376215 448 3146421
SGTC_1419 3993-2473 62.6 µM 0.23111641855827 0.41428447815122 no 1375 0.408612180109955 434 704026
SGTC_879 0831-1030 162 µM 0.230763082675468 0.414418271593074 no 1376 0.408749431470269 453 1549252
SGTC_727 3032-0951 202 µM 0.230089055443049 0.414673524893146 no 1377 0.409011284627093 454 3652836
SGTC_2071 5230951 39.92 µM 0.22953106777719 0.414884861416211 no 1378 0.409228088249997 455 1799272
SGTC_790 1575-0012 79.1 µM 0.228937980430203 0.415109518868643 no 1379 0.409458560140364 471 378741 YLR208W SEC13
SGTC_796 1234-0020 70.7 µM 0.228595713336524 0.415239179953037 no 1380 0.409591578310304 413 46495034
SGTC_729 4092-0585 94.1 µM 0.227575020150093 0.415625904037823 no 1381 0.409988320720143 407 2169061
SGTC_2656 pseudo-anisatin 100 µM 0.226942158535028 0.415865726108336 no 1382 0.410234359705 456 6708809 A neurotoxin.
SGTC_336 4111-0029 111 µM 0.225932421642581 0.416248429414927 no 1383 0.410626990444761 458 3131175
SGTC_2840 9008771 71.43 µM 0.225053070029199 0.416581779730282 no 1384 0.410968994563445 441 2992978
SGTC_204 PMA1.184 62.41 µM 0.225029241800638 0.416590813525792 no 1385 0.410978262962452 429 2252213 YGL008C PMA1
SGTC_1076 itraconazole 331 nM 0.224562608024964 0.41676773332988 no 1386 0.411159778198982 426 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_719 2810-4230 27.3 µM 0.223903653267424 0.417017598530283 no 1387 0.411416136500213 461 721079
SGTC_2307 7538926 6.34 µM 0.223220210325392 0.417276784675242 no 1388 0.41168206159038 433 96582
SGTC_397 arbidol 50 µM 0.223009751805639 0.417356605360484 no 1389 0.411763958388537 428 131410 A RNA synthesis inhibitor.
SGTC_1272 0839-0021 27 µM 0.221556196509924 0.417907988670331 no 1390 0.412329692548166 459 5027250
SGTC_354 2783-3500 4.88 µM 0.219287959050546 0.418768730906036 no 1391 0.413212870468795 430 6740761
SGTC_2619 obliquin 87.91 µM 0.21843892215449 0.419091020524986 no 1392 0.413543571083571 465 6708593 A bioactive alkalod. YER133W GLC7
SGTC_18 0111-0177 500 nM 0.217883323839412 0.419301951919524 no 1393 0.413760010330845 437 721752
SGTC_624 k048-0052 28 µM 0.217797820921615 0.419334414931369 no 1394 0.413793321232174 428 6835531
SGTC_596 1155-0152 116 µM 0.217795118571327 0.419335440945418 no 1395 0.413794374045235 464 280313
SGTC_1700 st030840 7.9285 µM 0.215578003096257 0.42017740780786 no 1396 0.414658351809973 441 5499307
SGTC_3129 9127257 49.47 µM 0.214261457108108 0.420677549570326 no 1397 0.415171586416438 454 837894
SGTC_370 0180-0345 38.7 µM 0.212735032214703 0.421257582364193 no 1398 0.415766820194708 415 3989527
SGTC_2168 5727979 200 µM 0.2117543340771 0.421630332359079 no 1399 0.416149348338505 448 695210
SGTC_1524 corynanthine 62.1 µM 0.211168147257978 0.421853167537339 no 1400 0.416378032551127 448 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2967 9089538 49.85 µM 0.211136662446595 0.421865136996198 no 1401 0.416390316261798 445 728216
SGTC_495 decylubiquinone 155 µM 0.207031179958238 0.42342651674911 no 1402 0.417992753949937 473 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_643 k048-0106 28.4 µM 0.206690578881253 0.423556107099249 no 1403 0.41812575774747 466 6763920
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.205741306070477 0.423917325700327 no 1404 0.418496495576503 441 688801
SGTC_2430 5571206 200 µM 0.205182668250321 0.424129929237626 no 1405 0.41871470505168 467 1731771
SGTC_2699 st077704 54.6 µM 0.203235152524211 0.424871277140087 no 1406 0.419475619193416 429 645852
SGTC_2052 5265182 7.135 µM 0.202469860685083 0.425162668602226 no 1407 0.419774709071498 472 1239884
SGTC_94 0334-0113 514.748 µM 0.202220374698248 0.425257671386946 no 1408 0.419872222728461 477 6795178
SGTC_248 streptozotocin 5.23457 mM 0.201967717778427 0.425353886067488 no 1409 0.419970980784718 453 5300 DNA alkylating agent.
SGTC_259 usnic acid 108.925 µM 0.201819168028112 0.425410457608134 no 1410 0.420029047981542 472 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3140 9094243 49.47 µM 0.201660905526422 0.425470729702231 no 1411 0.420090913749319 468 19291112
SGTC_2054 5233173 129 µM 0.20109255144517 0.425687193875092 no 1412 0.420313103059594 433 6889
SGTC_22 0964-0034 14.468 µM 0.200883816818216 0.425766698479679 no 1413 0.420394711040113 465 138402
SGTC_1875 nocodazole 6 µM 0.200202465535382 0.426026238288178 no 1414 0.420661119495997 455 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_658 3253-0951 102 µM 0.200150088203482 0.426046191149153 no 1415 0.420681600546566 465 1184878
SGTC_2745 rifampicin 24.3 µM 0.198852689392029 0.426540488502286 no 1416 0.421188989371153 480 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1242 0402-0103 60.1 µM 0.198669822362384 0.42661016850345 no 1417 0.421260515850511 432 432868
SGTC_2760 etidronate 98.04 µM 0.198091531820333 0.42683053649808 no 1418 0.421486725091759 455 3305 A chelator and antioxidant.
SGTC_3090 9117696 49.47 µM 0.197516322741741 0.427049752903633 no 1419 0.421711754668641 473 7923821
SGTC_2134 5324836 1.464 µM 0.19546118842709 0.427833163282657 no 1420 0.422515959391183 481 699272
SGTC_1940 st075990 51.1 µM 0.191441306798085 0.42936634880111 no 1421 0.424089930166622 437 1084979
SGTC_231 b-estradiol 524 µM 0.191355540471082 0.429399071832588 no 1422 0.424123524965461 454 450 A steroid.
SGTC_523 1934-0222 13.7 µM 0.190823120708791 0.42960222054359 no 1423 0.424332086910238 483 1361595
SGTC_2706 st078239 82.5 µM 0.190498909689613 0.429725934799679 no 1424 0.424459098742403 474 15434492
SGTC_750 4073-0104 132 µM 0.189680387695192 0.430038301683124 no 1425 0.424779795074895 457 22330957
SGTC_3349 9149703 23.001 µM 0.189191895290036 0.430224742538442 no 1426 0.424971209789608 448 4910494
SGTC_1156 4092-0367 4.88 µM 0.188952551810916 0.4303160974454 no 1427 0.425065002485402 473 1357585
SGTC_1459 k035-0031 35.7 µM 0.187517179971566 0.430864041983292 no 1428 0.425627577462464 436 3877128 YMR208W ERG12
SGTC_2662 daunorubicin 22.37 µM 0.187235804484914 0.430971471015246 no 1429 0.425737876645277 442 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_696 1560-0013 611 µM 0.186196135338884 0.431368460461517 no 1430 0.426145477259927 426 1650269
SGTC_1559 coumarin 343 70.1 µM 0.184895262085713 0.431865286245732 no 1431 0.4266555936149 453 108770 A hepatotoxic, DNA x-linker.
SGTC_2142 5622915 118.518 µM 0.183421023655175 0.432428453413845 no 1432 0.42723384059908 463 5322196
SGTC_3247 9135149 49.47 µM 0.183393381203515 0.432439014296987 no 1433 0.427244684416131 479 8934436 YOR116C RPO31
SGTC_578 3460-0051 92 µM 0.182898654416798 0.432628034333257 no 1434 0.427438769354363 483 2876744
SGTC_117 lucigenin 22.078 µM 0.181862239981051 0.433024066654671 no 1435 0.427845419200847 467 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2738 aclarubicin 5.55 µM 0.18106449451309 0.433328945176457 no 1436 0.428158476597132 472 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1723 st034307 2.5525 µM 0.179021993901109 0.434109718664784 no 1437 0.428960216015302 457 867466
SGTC_2880 9042983 58.44 µM 0.178041700817529 0.434484540461988 no 1438 0.429345113186032 455 6464714
SGTC_1891 st059073 26.2 µM 0.177943153283785 0.43452222405244 no 1439 0.429383810098754 487 688754
SGTC_2601 securinine 100 µM 0.177270067504886 0.434779621207153 no 1440 0.429648130543652 492 442872 A GABA receptor antagonist.
SGTC_3298 9116858 71.43 µM 0.173654608190762 0.436162692409698 no 1441 0.431068456409536 470 2506942
SGTC_3051 9093778 49.47 µM 0.172962089074453 0.436427700877481 no 1442 0.431340613489104 480 17217378
SGTC_2088 5278280 127.392 µM 0.171674144640868 0.436920638426607 no 1443 0.431846856795875 441 791502
SGTC_2723 salbutamol 83.58 µM 0.169968373771128 0.43757364217699 no 1444 0.432517504392944 476 9884233 β2-adrenoceptor agonist
SGTC_1939 st074455 53.6 µM 0.167652406418854 0.438460513421209 no 1445 0.43342837014012 489 1644229
SGTC_1165 k072-0275 30.3 µM 0.167401141857245 0.43855675076518 no 1446 0.433527213390768 465 6153523 YGL055W OLE1
SGTC_1340 1486-1359 257 µM 0.165995341339354 0.43909525611121 no 1447 0.434080308192205 469 4309068
SGTC_2451 5856223 45.7 µM 0.165459073376268 0.439300708449163 no 1448 0.434291330250309 472 2179896
SGTC_1829 berberine 14.4 µM 0.164869561203471 0.439526578312105 no 1449 0.434523325569597 472 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.163828527452923 0.439925495382414 no 1450 0.434933066715165 479 61125 An anti-inflammatory.
SGTC_2235 salicylic acid 500 µM 0.163503172555485 0.44005018170133 no 1451 0.435061137713666 457 338 A COX inhibitor and kinase inhibitor.
SGTC_1474 0330-0125 5.35 µM 0.163418630346417 0.440082581931754 no 1452 0.435094417581965 480 X1474
SGTC_1198 1612-1005 86.7 µM 0.161958327252838 0.440642296366329 no 1453 0.435669335282602 485 6998509
SGTC_559 1550-0661 158 µM 0.16107617609529 0.440980470519253 no 1454 0.436016701965718 473 5830875
SGTC_871 0574-0004 149 µM 0.158861517019709 0.441829652988995 no 1455 0.43688899028108 486 9551173
SGTC_1838 st055369 84.5 µM 0.158735306914435 0.441878054717745 no 1456 0.436938709970434 427 676036
SGTC_1258 0671-0043 57.1 µM 0.157603646023789 0.44231208673673 no 1457 0.437384565185957 458 4298767
SGTC_1850 st056238 17 µM 0.156940323413669 0.442566526671627 no 1458 0.437645940059412 496 5393177
SGTC_1290 0986-0249 10.2 µM 0.156765589421918 0.442633555780444 no 1459 0.437714796571949 473 53329
SGTC_1151 3909-8316 15.3 µM 0.156740008790929 0.44264336881663 no 1460 0.437724877156074 473 800431
SGTC_3309 9129340 25.759 µM 0.154186781554084 0.443622993388833 no 1461 0.438731232174245 459 17158987
SGTC_766 1391-0721 126 µM 0.154095491948814 0.443658025885261 no 1462 0.438767221365487 483 1020919 YIL115C NUP159
SGTC_2211 7117706 200 µM 0.153753004631094 0.44378945973016 no 1463 0.43890224498917 492 822771
SGTC_1697 st025554 27.742 µM 0.153057751803303 0.444056290807798 no 1464 0.43917636620511 472 1269519
SGTC_179 1273-0063 6.77 µM 0.151909225445561 0.44449713922648 no 1465 0.439629265945586 483 3108139
SGTC_1771 st048882 4.1505 µM 0.151443579777663 0.444675891468854 no 1466 0.439812907093085 442 4580403
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.151388296083253 0.444697114543178 no 1467 0.439834710714624 463 3256 An antibiotic and ribosome inhibitor.
SGTC_2401 5128683 200 µM 0.150905149273788 0.444882598407952 no 1468 0.440025269237144 476 708373
SGTC_1043 0916-0009 19.3 µM 0.150461096683179 0.445053084338809 no 1469 0.440200420815266 497 3101130
SGTC_2980 9014342 25.29 µM 0.148912432053268 0.445647745341641 no 1470 0.4408113656174 483 2996599
SGTC_3220 9131269 49.47 µM 0.148485343773075 0.445811761582606 no 1471 0.440979875856947 496 17722206
SGTC_79 0052-0007 94.094 µM 0.147224876869489 0.446295877167172 no 1472 0.441477262822033 488 2801472
SGTC_3151 9099821 49.47 µM 0.147224029395222 0.446296202689047 no 1473 0.44147759727104 463 17174189
SGTC_1810 st050138 53 µM 0.147129990118997 0.446332324177554 no 1474 0.441514709385719 503 3444541
SGTC_1968 st069590 43.6 µM 0.142271717366396 0.448199037544372 no 1475 0.44343269276245 494 6384066
SGTC_811 0416-0114 265 µM 0.138124968049972 0.449793268944778 no 1476 0.445070826627534 494 6612453
SGTC_892 0929-0076 29 µM 0.138011785398918 0.449836793868786 no 1477 0.445115551640653 476 5751038
SGTC_1484 3473-2379 286 µM 0.13719153139607 0.450152244428502 no 1478 0.445439702292629 508 671917
SGTC_300 r073-0011 5.04 µM 0.136689812029303 0.450345209533541 no 1479 0.445637991382507 477 2735780
SGTC_2145 5634607 200 µM 0.135046206492025 0.450977434770556 no 1480 0.446287670713575 472 308662
SGTC_1912 st060209 90.8 µM 0.133971738061514 0.451390804476148 no 1481 0.446712461348046 496 688787
SGTC_2580 diallyl disulphide 81.36 µM 0.133287800672162 0.451653956488842 no 1482 0.446982887584406 488 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2890 9046729 58.44 µM 0.132662361585632 0.451894619272145 no 1483 0.447230205398481 474 903329
SGTC_2330 7979373 200 µM 0.131547230921174 0.452323754341562 no 1484 0.447671213145475 469 1863007
SGTC_3182 9108849 49.47 µM 0.129736148430051 0.453020830615593 no 1485 0.448387590968668 466 17133045
SGTC_597 k018-0003 82.8 µM 0.12916318141742 0.45324139290464 no 1486 0.448614264544567 487 6786234
SGTC_3017 9080681 49.47 µM 0.127232572177577 0.453984682140964 no 1487 0.449378162998503 492 16451914
SGTC_2176 5809774 33.9695 µM 0.126684402722891 0.45419575820472 no 1488 0.449595095594712 512 2870539
SGTC_2833 9001315 45.46 µM 0.126216596531559 0.45437590012639 no 1489 0.449780237147453 474 2989378
SGTC_3190 9110366 49.47 µM 0.126113542225845 0.45441558534586 no 1490 0.449821023957388 491 17123768
SGTC_1274 0865-0114 173 µM 0.125462053487525 0.454666477892476 no 1491 0.450078882274343 466 870624
SGTC_2287 7945887 168.79 µM 0.124820812347155 0.454913441685267 no 1492 0.450332705189897 490 1245853
SGTC_1996 st072960 66.8 µM 0.123303567113533 0.455497853705954 no 1493 0.450933358121063 480 1719405
SGTC_1333 1482-0047 286 µM 0.122354720612039 0.455863379119182 no 1494 0.451309048358952 510 3811116
SGTC_3210 9128157 49.47 µM 0.121048358692789 0.456366691742897 no 1495 0.451826366040158 450 17590849
SGTC_2651 TUB2.036 5 µM 0.120995885917111 0.456386909821684 no 1496 0.451847146908376 468 15992207 YFL037W TUB2
SGTC_3018 9082602 49.47 µM 0.120916565826435 0.456417472548141 no 1497 0.451878560407504 488 17332089
SGTC_466 geldanamycin 89.2 µM 0.118418467719741 0.457380142651147 no 1498 0.452868046804131 493 5288382 HSP90 inhibitor.
SGTC_1852 st056254 31.4 µM 0.118100953726335 0.457502518260837 no 1499 0.452993833888893 491 442583
SGTC_2441 5730946 39.09 µM 0.117676169366072 0.457666244100601 no 1500 0.453162124826898 481 1774275
SGTC_360 0957-0399 1.01 µM 0.115275550248947 0.458591655755784 no 1501 0.454113358614247 485 6752301 YPR165W RHO1
SGTC_60 0986-0278 202 µM 0.115001055643944 0.458697484731982 no 1502 0.454222142656821 499 3110598
SGTC_3063 1327-0034 4 µM 0.114157559642304 0.459022705470147 no 1503 0.454556447202334 504 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_232 clozapine 119 µM 0.113965399328563 0.459096799195627 no 1504 0.45463261101464 490 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2265 7929201 200 µM 0.110409912584109 0.460467987658873 no 1505 0.456042146044256 504 1265108
SGTC_2236 dapsone 200 µM 0.109880542952217 0.460672181903082 no 1506 0.456252056784637 498 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.109792263717136 0.460706234945542 no 1507 0.45628706330588 491 688803
SGTC_1440 4100-1550 40 µM 0.1096692430152 0.460753689724722 no 1508 0.456335846881776 511 742806
SGTC_1228 0124-0032 52.5 µM 0.109209013096109 0.460931226659189 no 1509 0.456518355826758 486 X1228
SGTC_307 1501-1223 22.3 µM 0.108630999758461 0.461154210404975 no 1510 0.456747585997932 497 2830329
SGTC_777 1315-0167 517 µM 0.108232798215607 0.461307834162905 no 1511 0.456905514275117 506 4221767
SGTC_2031 5180455 200 µM 0.107673673672427 0.461523550785784 no 1512 0.457127276721603 511 29949
SGTC_224 benfluorex 43.875 µM 0.107245232696638 0.461688855862703 no 1513 0.457297215912869 510 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2131 toluylene red 5.2905 µM 0.1066288141828 0.461926699783785 no 1514 0.457541729242679 472 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1687 st020778 55.3625 µM 0.105756859734511 0.462263164996279 no 1515 0.457887632855472 506 4259299
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.105056847383017 0.462533301647961 no 1516 0.458165350276079 465 4174840
SGTC_1668 st014914 51.6 µM 0.104700477459947 0.462670832407192 no 1517 0.458306741543808 508 2839556
SGTC_178 4092-0806 87.505 µM 0.104412990670042 0.462781782948009 no 1518 0.458420806983843 498 2169044
SGTC_2517 totarol 10 µM 0.104194510419074 0.462866103548757 no 1519 0.458507495156231 480 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1750 st081859 2.357 µM 0.103998206360446 0.462941866859286 no 1520 0.458585385985068 499 5291695
SGTC_1279 0874-0590 65.2 µM 0.103961207051018 0.462956146848002 no 1521 0.458600066995119 485 3523074
SGTC_159 3970-0959 50 µM 0.103958767785629 0.462957088291094 no 1522 0.458601034876781 489 6615653
SGTC_3085 9117376 49.47 µM 0.10352002362621 0.46312642651893 no 1523 0.458775129156611 510 16480349
SGTC_536 3852-0578 10.6 µM 0.103390453867825 0.463176436699409 no 1524 0.458826544127053 467 2869208
SGTC_622 1348-1566 26.3 µM 0.103168617291858 0.463262060554484 no 1525 0.45891457337304 496 7340407
SGTC_1816 st051957 91.6 µM 0.102977224822923 0.463335935046901 no 1526 0.458990523399904 505 674121
SGTC_1477 0139-0234 16 µM 0.102469585981451 0.463531881798423 no 1527 0.459191976310531 494 620880
SGTC_1086 cerivastatin 2.18 µM 0.102418368401294 0.46355165209073 no 1528 0.459212302230513 495 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1898 st060199 18.6 µM 0.102112410132949 0.463669755685705 no 1529 0.459333725322271 502 688866
SGTC_2398 5228213 48.84 µM 0.101833425592105 0.46377744988646 no 1530 0.459444446883972 496 80771 YMR134W ERG29
SGTC_3324 9138759 60.749 µM 0.10164914036379 0.463848589515117 no 1531 0.459517586527019 489 45595710
SGTC_2937 9044753 11.33 µM 0.101082556583827 0.464067315087923 no 1532 0.459742462472326 499 6465530 YGL099W LSG1
SGTC_118 0083-0097 135.343 µM 0.100411326273928 0.464326452746403 no 1533 0.460008889073255 515 5207356
SGTC_1714 st033236 13.627 µM 0.100032249498622 0.46447280722329 no 1534 0.460159361222982 497 2916566
SGTC_84 0443-0269 128.823 µM 0.0990937059486036 0.464835182035386 no 1535 0.460531934708901 515 6150058
SGTC_2721 ifenprodil 61.44 µM 0.0979384134412766 0.465281284364018 no 1536 0.460990598540501 492 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1060 3448-7350 82 µM 0.0977143272551111 0.465367817624139 no 1537 0.461079569249472 481 570178
SGTC_1354 1498-1681 81 µM 0.0976918085155909 0.465376513565129 no 1538 0.461088510150339 488 5754243
SGTC_2263 7948595 193.29 µM 0.0964808913331372 0.46584415120772 no 1539 0.461569324813454 491 2971371
SGTC_1965 Pectolinarigenin 58.4 µM 0.0964478853960786 0.465856898257609 no 1540 0.461582431155436 487 5320438 An anti-inflammatory.
SGTC_514 4466-0038 2.65 nM 0.0956999997105561 0.466145744631053 no 1541 0.461879420565536 513 5722064
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.0943672528109846 0.466660518619031 no 1542 0.462408714081064 489 688761
SGTC_1710 st031758 61.5 µM 0.0932767719390651 0.467081758790891 no 1543 0.462841842462732 509 5394341
SGTC_667 1498-1044 59 µM 0.0924443891549692 0.46740332348986 no 1544 0.463172486475509 511 6739982
SGTC_1246 0422-0085 105 µM 0.092164474979013 0.467511464247765 no 1545 0.463283681368143 516 264295
SGTC_1018 4259-0013 28.1 µM 0.0897503381459876 0.468444229472453 no 1546 0.464242806630681 490 6801262
SGTC_3229 9132204 49.47 µM 0.0894206512949561 0.468571626213913 no 1547 0.464373805926733 515 17682924
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.0889907426509338 0.46873775523433 no 1548 0.464544633612235 503 2333 A French combination drug.
SGTC_798 1287-0182 476 µM 0.088467027752888 0.468940141031669 no 1549 0.464752744800632 506 1649755
SGTC_1154 4088-0362 150 µM 0.0878376904256079 0.46918335445836 no 1550 0.465002840448345 509 6618304
SGTC_2839 9003951 25.97 µM 0.0874843386520436 0.469319915676162 no 1551 0.465143266822114 515 2990634
SGTC_394 menadione 8.33 µM 0.0872003782444692 0.469429661562524 no 1552 0.465256119353921 518 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1187 1391-0724 117 µM 0.0868501053894078 0.469565039284888 no 1553 0.465395329857531 487 6997986
SGTC_1785 bathophenanthroline 24 µM 0.0863689505834069 0.469751007591804 no 1554 0.465586564259754 509 72812 An iron chelator.
SGTC_2352 9027995 87.8 µM 0.0849869497622963 0.470285193135091 no 1555 0.466135882876039 499 2997347
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.084785424412496 0.470363093330863 no 1556 0.466215990722827 517 6708784 An antioxidant flavonoid
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.0846853819935735 0.470401765433229 no 1557 0.466255758847642 490 803109
SGTC_686 1319-0111 510 µM 0.0836379919274221 0.470806658139018 no 1558 0.466672129778691 509 4562600
SGTC_10 0279-0212 42.575 µM 0.0823147798965577 0.471318219262019 no 1559 0.467198200823877 494 39851 YBR002C RER2
SGTC_2474 5321570 43.32 µM 0.0815641041076269 0.471608455787907 no 1560 0.46749667346083 521 2841384
SGTC_2805 7950783 58.44 µM 0.080656079682801 0.471959548728976 no 1561 0.467857733149409 490 1178958 YDL195W SEC31
SGTC_1302 1159-0335 255 µM 0.0792394688940077 0.472507332969249 no 1562 0.468421075817493 506 649284
SGTC_3311 9131146 2.8755 µM 0.0787056602904635 0.472713763085265 no 1563 0.468633371594398 492 4900406 YPR165W RHO1
SGTC_2009 4012297 12.05 µM 0.0782596399787129 0.472886250050435 no 1564 0.468810760794352 495 45595307
SGTC_819 1013-0258 27.7 µM 0.0772259122872621 0.473286037328859 no 1565 0.469221914086604 498 5753198
SGTC_2047 4141938 200 µM 0.0772187047443679 0.473288824892853 no 1566 0.469224780919575 522 3807862
SGTC_2636 apigenin dimethyl ether 100 µM 0.0760090184024372 0.473756697362518 no 1567 0.46970596165446 505 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_605 1315-0399 119 µM 0.0757525975667857 0.473855878362764 no 1568 0.469807964682508 496 24020461
SGTC_1805 st050013 60.3 µM 0.0751786464945974 0.474077882728922 no 1569 0.470036286947902 523 4037144
SGTC_3005 9076496 71.4286 µM 0.0738349676736978 0.474597649274973 no 1570 0.470570851385413 506 21368410
SGTC_3211 9128781 49.47 µM 0.0736127943765634 0.474683595317157 no 1571 0.470659245160933 489 17194361
SGTC_196 k015-0023 18.111 µM 0.0732644430888791 0.47481835472107 no 1572 0.470797842967972 516 5211998
SGTC_1505 k297-0037 20.6 µM 0.0730578472586089 0.474898277506971 no 1573 0.470880042496165 489 4089396
SGTC_2950 9072895 21.46 µM 0.0719947391334557 0.475309562906215 no 1574 0.471303047275862 503 17332245
SGTC_1266 0828-0227 32.9 µM 0.0716391104227254 0.475447151133862 no 1575 0.471444557202201 501 3913820
SGTC_641 4092-0595 30 µM 0.0715442755223228 0.475483842046509 no 1576 0.471482294022002 505 786260
SGTC_408 cantharidin 100 µM 0.0708231851634008 0.475762833283193 no 1577 0.47176923953208 494 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1002 4049-0206 172 µM 0.0708069140217059 0.47576912875659 no 1578 0.471775714522783 517 4662749
SGTC_2015 5119600 184 µM 0.0697233787499755 0.476188373322018 no 1579 0.472206916755148 514 2828786
SGTC_423 5-fluorouracil 457 µM 0.0694103269518569 0.476309505147582 no 1580 0.472331504513664 521 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3342 9147791 14.508 µM 0.0690874801335916 0.476434429337538 no 1581 0.472459993311097 520 1838168
SGTC_1753 st043925 64 µM 0.0689685269418247 0.476480458348846 no 1582 0.472507335843794 515 670181
SGTC_1126 isoteolin 1.0172 µM 0.0672790223601203 0.477134246785022 no 1583 0.473179788387562 503 133323
SGTC_3121 9125696 49.47 µM 0.0667486508860632 0.477339497677274 no 1584 0.473390901418872 529 1235365
SGTC_348 k064-0012 10.7 µM 0.0663371191612377 0.477498762373821 no 1585 0.473554715739433 510 5066323
SGTC_2073 5212005 126 µM 0.0661959910762133 0.477553380429655 no 1586 0.473610894216896 527 691789
SGTC_818 4072-2707 53.5 µM 0.0654722046510556 0.477833500005872 no 1587 0.473899018157486 499 882871
SGTC_3056 9094900 49.47 µM 0.0649122864575168 0.478050206874963 no 1588 0.474121919024356 502 25236784
SGTC_3262 9137218 49.47 µM 0.0640717116117064 0.478375549320564 no 1589 0.474456563207184 518 17650664
SGTC_2581 avocatin a 64 µM 0.0633674532270608 0.478648141915584 no 1590 0.474736951854278 506 6710728 A skin care supplement.
SGTC_2276 7947513 42.08 µM 0.0628765096340225 0.478838174093168 no 1591 0.474932420210178 502 2105100
SGTC_2720 fluspirilene 36.88 µM 0.0619096957361999 0.479212417974119 no 1592 0.475317373115194 505 3396 An atypical antipsychotic.
SGTC_3100 9120536 49.47 µM 0.0618814412515511 0.479223355276578 no 1593 0.47532862345271 520 16421196
SGTC_2354 9060492 162 µM 0.0613903591285128 0.479413455509613 no 1594 0.475524165089997 501 6471895
SGTC_3143 9086658 49.47 µM 0.0613692962394646 0.479421609159506 no 1595 0.475532552153035 497 25236626
SGTC_213 1246-0773 967 nM 0.0598974917141444 0.479991380184448 no 1596 0.476118638816086 519 6251622
SGTC_3163 9099914 49.47 µM 0.0595962825765646 0.480107990583113 no 1597 0.476238589591109 521 16268368
SGTC_1172 0370-0043 85 µM 0.0595478021478183 0.480126759502793 no 1598 0.476257896195583 516 376585
SGTC_41 0478-0632 82.643 µM 0.0559587465585203 0.481516361330731 no 1599 0.477687335556877 530 3750424
SGTC_2844 9010103 25.97 µM 0.053215934130703 0.482578469098128 no 1600 0.47877993000202 525 2480525
SGTC_454 lyso-paf C-16 6.67 µM 0.0527005476217319 0.482778057843234 no 1601 0.478985251347376 511 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1495 4469-0029 237 µM 0.052268284321364 0.482945459597934 no 1602 0.479157462102333 509 793680
SGTC_2532 xanthone 78.9 µM 0.0505790586871121 0.483599671231699 no 1603 0.479830475104751 532 7020 An insecticide.
SGTC_2750 bromebric acid 70.15 µM 0.0501272631204329 0.483774652403739 no 1604 0.480010487107268 515 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2565 isoliquiritigenin 100 µM 0.049989106176067 0.483828161442814 no 1605 0.480065534740657 525 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1487 3970-0795 2.82 µM 0.0497899517339495 0.483905295702326 no 1606 0.480144887053774 516 3765103
SGTC_2239 6685329 187.64 µM 0.0485730990567953 0.484376606377544 no 1607 0.480629754247263 478 805680
SGTC_683 panaxydol 45 µM 0.0483837945527463 0.484449929667331 no 1608 0.480705187125927 515 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1112 tnp00069 1.16933 µM 0.0470203523066766 0.484978046961972 no 1609 0.481248503336243 533 145826
SGTC_968 1309-0633 340 µM 0.0462233313972939 0.485286778225383 no 1610 0.481566123290565 527 3761976
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.0460963644142039 0.485335960536104 no 1611 0.481616721853599 515 16725076
SGTC_2600 tangeritin 87.95 µM 0.0459922000087295 0.485376310138695 no 1612 0.481658233411878 526 68077 A bioactive flavone.
SGTC_3230 9131665 49.47 µM 0.0459652108690636 0.485386764800252 no 1613 0.481668989145758 527 15943720
SGTC_2889 9059656 51.95 µM 0.0456964348161972 0.48549087991706 no 1614 0.481776102723666 526 3949838
SGTC_1215 3852-0577 11.2 µM 0.0452963874563837 0.485645847105862 no 1615 0.481935533438495 518 2884876
SGTC_1928 4'-methoxychalcone 40.3 µM 0.0450882949277262 0.485726457205774 no 1616 0.482018465614837 528 641818
SGTC_3118 9124250 49.47 µM 0.0442953923281288 0.486033614145173 no 1617 0.482334472230521 527 1504786
SGTC_1371 2421-0008 32.7 µM 0.0435514819491653 0.486321799871522 no 1618 0.482630963383203 523 2827552
SGTC_940 3232-1287 54.8 µM 0.0430425743576015 0.486518951270373 no 1619 0.482833797926851 528 1585493 YIL048W NEO1
SGTC_1214 0358-0031 63.7 µM 0.0423150806960003 0.486800788879246 no 1620 0.483123761698566 513 4301366
SGTC_1997 st073024 93.8 µM 0.0415181457661255 0.487109536223389 no 1621 0.48344141354827 536 686268
SGTC_3313 9133968 57.047 µM 0.0411627953660979 0.487247208048002 no 1622 0.483583056758158 532 1494643
SGTC_1621 st003705 32.4 µM 0.0405476570608249 0.487485531928056 no 1623 0.483828256709458 522 24207032
SGTC_2125 5246583 200 µM 0.0401764797861716 0.487629339817695 no 1624 0.483976214449172 530 835267
SGTC_1204 4049-0315 18.3 µM 0.0393060773505336 0.487966572389068 no 1625 0.484323180668672 510 588402
SGTC_2978 9011784 42.97 µM 0.0389380708329283 0.488109157064628 no 1626 0.484469881718544 514 2994934
SGTC_3354 9151612 71.43 µM 0.0384125926168767 0.488312757015246 no 1627 0.484679360468152 529 27261949
SGTC_844 0330-0132 15.3 µM 0.0373743641537722 0.488715034285326 no 1628 0.485093256413681 537 2828079
SGTC_2458 5808907 16.39 µM 0.0373647183532555 0.488718771750615 no 1629 0.485097101845359 531 2731747
SGTC_327 1273-0057 3.96 µM 0.0370604025433566 0.488836685724073 no 1630 0.485218422258251 537 3108138
SGTC_2044 5102272 200 µM 0.0368562985093551 0.488915770948762 no 1631 0.485299792395356 527 592666
SGTC_1007 4101-0031 70 µM 0.0353962702568488 0.489481508020159 no 1632 0.485881879376922 534 1146276
SGTC_3091 9116372 49.47 µM 0.0353092621745566 0.489515222908599 no 1633 0.485916568895106 516 17169793
SGTC_1108 betulinic acid 729.144 nM 0.0352583632286851 0.489534945849962 no 1634 0.485936862000782 530 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_337 1315-0038 354 µM 0.0336078641905435 0.490174514846255 no 1635 0.486594925547545 535 1626437
SGTC_2107 5363541 170.161 µM 0.0330989166297928 0.490371737389694 no 1636 0.486797853341074 535 244052
SGTC_706 4262-0057 46.9 µM 0.0328908683665465 0.490452358964824 no 1637 0.486880807422689 525 883298
SGTC_2748 diazoxide 86.69 µM 0.0325165850068578 0.490597399915414 no 1638 0.487030045050167 537 3019 A potassium channel activatior.
SGTC_1864 st057645 30.4 µM 0.0324091669698384 0.490639026399872 no 1639 0.487072876072358 535 688666
SGTC_743 1275-0778 158 µM 0.0305424423670089 0.491362432740482 no 1640 0.487817222521136 528 2849257 YMR203W TOM40
SGTC_2994 9053520 71.4286 µM 0.0297019950030285 0.491688138273639 no 1641 0.488152360421365 522 4647384
SGTC_3088 9117578 49.47 µM 0.0283817156476668 0.492199808183339 no 1642 0.488678853563227 531 678341
SGTC_1591 genipin 88.4 µM 0.0250489432044639 0.493491468340388 no 1643 0.490007962403882 539 442424 A DNA cross-linking agent.
SGTC_517 1365-0151 113 µM 0.0244891889957501 0.493708415568782 no 1644 0.490231203530997 520 768657
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.0236458349611058 0.49403528274198 no 1645 0.490567555673519 532 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1339 1486-1321 22.7 µM 0.0236355140660363 0.494039282939945 no 1646 0.490571671964514 528 3469382
SGTC_859 0439-0102 54.6 µM 0.0227301196999054 0.494390200208658 no 1647 0.490932774996083 525 610143
SGTC_40 0327-0103 19.753 µM 0.0225673195773959 0.49445329956128 no 1648 0.4909977061923 535 409036
SGTC_826 1683-5028 118 µM 0.0223698948380703 0.494529819181403 no 1649 0.491076447389591 529 722377
SGTC_2569 tetrandrine 100 µM 0.0218194366512674 0.494743171670013 no 1650 0.491295994835883 534 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1901 st060216 58.6 µM 0.0216869102630911 0.494794537896001 no 1651 0.49134885270769 531 688792
SGTC_862 0452-0056 10.2 µM 0.0212224471558368 0.494974560960107 no 1652 0.491534104036395 539 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1030 k029-0042 36.7 µM 0.0210294414285712 0.495049369104501 no 1653 0.49161108500081 530 6080581
SGTC_1516 st013856 110 µM 0.0209846697674738 0.495066722422226 no 1654 0.491628942368753 535 5281404 A mutagen and neurotoxin.
SGTC_1259 0671-0132 43 µM 0.0198606374916221 0.495502395833322 no 1655 0.492077272838872 534 X1259
SGTC_529 4076-0302 30.3 µM 0.0194899814626217 0.495646062817445 no 1656 0.492225114580625 521 5816522
SGTC_2183 6420625 130.508 µM 0.0184329629382728 0.496055768252669 no 1657 0.492646728141791 529 2897619
SGTC_1641 st009299 47.1 µM 0.0179138150684631 0.496256994000078 no 1658 0.492853803976007 540 4046054
SGTC_97 0535-0701 19.132 µM 0.017863513695322 0.496276491254507 no 1659 0.492873868109952 530 2832013 YGL099W LSG1
SGTC_2528 xanthyletin 44.79 µM 0.0176083788575107 0.496375383896526 no 1660 0.492975636176149 539 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_3201 9113999 49.47 µM 0.0174418857482789 0.496439918298531 no 1661 0.493042047117553 530 16649224
SGTC_136 0097-0015 404.482 µM 0.0163442492957999 0.49686537546911 no 1662 0.493479878207339 535 4861337
SGTC_1726 st035556 14.5795 µM 0.015602330490708 0.497152954224314 no 1663 0.493775823223528 517 5919439
SGTC_1427 4048-4900 550 nM 0.0155569225948169 0.497170555049175 no 1664 0.4937939361547 540 24132586
SGTC_2895 9054447 58.44 µM 0.0153488953784314 0.49725118978689 no 1665 0.49387691709844 536 2697450
SGTC_513 4245-1575 41.7 µM 0.0141507401653004 0.497715616349111 no 1666 0.494354859850103 535 719745
SGTC_1911 st060208 74.3 µM 0.0139472070644802 0.497794509773433 no 1667 0.494436049796567 536 688783
SGTC_1936 st074407 74.3 µM 0.0128274291196465 0.498228559140936 no 1668 0.494882736510633 545 809813
SGTC_3053 9095903 49.47 µM 0.0124705157786318 0.498366906687063 no 1669 0.495025112941727 545 17174018
SGTC_974 1326-0144 138 µM 0.0118175471410236 0.498620012344685 no 1670 0.495285590526418 537 5411856
SGTC_305 1682-2595 20.8 µM 0.0113741361030395 0.498791888981232 no 1671 0.495462474043025 544 226033
SGTC_1910 st062352 60.4 µM 0.0106359077871808 0.499078044269864 no 1672 0.495756966690507 544 2245730
SGTC_430 0958-0115 16.4 µM 0.00980440739741683 0.499400354648339 no 1673 0.496088670018672 540 6833180
SGTC_2944 9067346 25.62 µM 0.00959976262115976 0.49947968015768 no 1674 0.496170307629858 538 6473075
SGTC_2756 carbadox 75.1 µM 0.00920558033178911 0.499632475272979 no 1675 0.49632755665889 542 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2673 kobusone 100 µM 0.00906089238896871 0.499688560026914 no 1676 0.496385276389271 545 6710676 An epoxy ketone and protein crosslinker.
SGTC_756 0508-1999 28.3 µM 0.00884525147016901 0.499772147983434 no 1677 0.496471301221161 545 6753853
SGTC_1583 clindamycin 39.6 µM 0.0086142350965225 0.499861695872005 no 1678 0.496563459908168 541 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2081 5214970 32.255 µM 0.00790063892294006 0.499861695872005 no 1679 0.496848133881452 542 2063512
SGTC_298 1391-0729 10 µM 0.00751488692469448 0.49971216848141 no 1680 0.49700202209106 539 3237558
SGTC_400 oxethazaine 37.5 µM 0.00624071294733624 0.499218266296056 no 1681 0.497510331906112 545 4621 A local anesthetic.
SGTC_211 3455-0679 143.504 µM 0.00558149064678254 0.498962735416982 no 1682 0.497773318954652 532 748649
SGTC_329 k048-0121 21.3 µM 0.0052735501114818 0.498843370183589 no 1683 0.497896167644098 542 6832902
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.00482452057828054 0.498669315615126 no 1684 0.498075302225204 544 4000243
SGTC_994 3910-0338 138 µM 0.0044244375780568 0.498514234103903 no 1685 0.498234910541913 546 3479481
SGTC_177 1327-0068 8.361 µM 0.00438858622776433 0.498500337294158 no 1686 0.498249213022495 546 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_72 0744-0168 198.391 µM 0.00198025362577367 0.497566817084369 no 1687 0.499209993619083 546 677577
SGTC_1929 genistein trimethyl ether 50.5 µM 0.00173531719549563 0.497471875249307 no 1688 0.499307708948261 546 136420
SGTC_3070 9117005 49.47 µM 0.00117792268481755 0.497255819496263 no 1689 0.499530076946652 546 8779016
SGTC_1449 4112-4002 201 µM 0.00075257028707666 0.497090946088097 no 1690 0.499699767921851 548 2059539
SGTC_753 1322-0200 289 µM 0.00059712592865412 0.497030693485337 no 1691 0.499761781234492 548 5403907
SGTC_2476 5806916 10.51 µM 0.000377094184707658 0.496945405943563 no 1692 0.499849561189592 547 2870194
SGTC_374 0880-0231 82.3 µM 4.52211879861025e-05 0.496816767351784 no 1693 0.499981959356149 547 6833587
SGTC_3198 9112019 49.47 µM -0.00014268975541371 0.496743930601111 no 1694 0.499943075023778 548 45595555
SGTC_2359 9039622 200 µM -0.00101609474414992 0.496405388815016 no 1695 0.499594636915418 548 6463596
SGTC_2499 avocadenofuran 51.48 µM -0.00280235123559342 0.495713023647213 no 1696 0.498882025070862 555 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2418 pentamidine 31.67 µM -0.00481932605007418 0.494931246118298 no 1697 0.498077374518041 552 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2995 9067767 71.4286 µM -0.00490144016840339 0.494899419155807 no 1698 0.498044616111364 554 11673567
SGTC_3033 9090887 49.47 µM -0.00513921684960404 0.494807258458334 no 1699 0.497949758135556 539 19325384
SGTC_21 0849-0113 22.993 µM -0.00538059260641821 0.494713703066027 no 1700 0.497853464473001 552 1560156
SGTC_284 0988-0104 32.6 µM -0.00586100014540223 0.494527501658266 no 1701 0.497661812623206 549 4666532
SGTC_2443 5493264 126.67 µM -0.00714885522004564 0.494028347234847 no 1702 0.497148043688351 554 5340055
SGTC_1179 1021-1431 9.29 µM -0.0078980453717033 0.493737975973157 no 1703 0.496849168526416 550 2840958
SGTC_2086 5274770 176.623 µM -0.00987854734711373 0.49297038902487 no 1704 0.496059093890405 554 689278
SGTC_1150 3909-7983 10.9 µM -0.0100776924340169 0.492893207374714 no 1705 0.495979650450344 553 23965914
SGTC_234 nsc-17383 10.7 µM -0.0101840761558846 0.492851976884643 no 1706 0.495937211663669 553 408974
SGTC_550 4123-0385 25.7 µM -0.0103952609650173 0.492770129503233 no 1707 0.495852965574475 560 5731123
SGTC_1308 1187-1617 41.4 µM -0.0105352498822371 0.492715875170424 no 1708 0.495797121134823 554 2882570
SGTC_314 1671-0008 2.74 µM -0.0107152394072693 0.492646118335032 no 1709 0.495725319756508 557 3913060
SGTC_73 0327-0325 16.231 µM -0.0107472168805336 0.492633725152068 no 1710 0.495712563324934 555 53298
SGTC_3323 9138564 53.9225 µM -0.0113419115172552 0.492403246729426 no 1711 0.495475328963563 553 43912313 YNL103W MET4
SGTC_3122 9126309 49.47 µM -0.0114169045076867 0.492374182804959 no 1712 0.495445413025937 552 17591206
SGTC_2025 5147754 141 µM -0.0130570809418028 0.49173853426943 no 1713 0.494791126361967 552 315777 YLR208W SEC13
SGTC_1252 0493-0875 34.8 µM -0.0131049458468882 0.491719984586406 no 1714 0.494772032661242 560 3960963
SGTC_249 wiskostatin 11.211 µM -0.0134193275729542 0.49159814876607 no 1715 0.494646623528277 557 2775510 A n-wasp and actin depolymerizer.
SGTC_2649 anisomycin 9.56 µM -0.0135885700142628 0.491532560698594 no 1716 0.494579111718775 557 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1045 1348-1485 165 µM -0.0137221787691233 0.491480782240373 no 1717 0.494525814506846 550 6810614
SGTC_2822 7994718 71.43 µM -0.0156980552619875 0.490715072411851 no 1718 0.493737639241458 551 1018011
SGTC_1979 st071809 45.3 µM -0.0161816752973703 0.490527660632489 no 1719 0.4935447272726 571 4976333
SGTC_1937 st074714 47.2 µM -0.0162170667511272 0.490513945866004 no 1720 0.493530609977781 564 17250970
SGTC_1752 st044819 83.042 µM -0.0167274956714784 0.490316147576357 no 1721 0.493327005926957 561 441209 YML126C ERG13
SGTC_271 rotenone 740 µM -0.0178942308598978 0.489864030521855 no 1722 0.492861615692693 557 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_3039 9090270 49.47 µM -0.0180967539014697 0.489785552909051 no 1723 0.49278083376997 555 17173750
SGTC_1919 st067113 52.3 µM -0.0189293860071183 0.489462912426584 no 1724 0.492448718547025 558 1268243
SGTC_202 3594-0513 34.79 µM -0.0192398645997858 0.489342605388023 no 1725 0.492324878064573 562 708429
SGTC_2697 mebhydrolin 72.4 µM -0.0203898847986074 0.488896993747722 no 1726 0.491866176467893 561 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_525 k781-2675 26.7 µM -0.0209404622636705 0.488683659995022 no 1727 0.491646574736616 553 3651118 YDL195W SEC31
SGTC_813 k007-0158 173 µM -0.0220446816180446 0.488255814928509 no 1728 0.49120615670473 556 6523916
SGTC_1273 0849-0096 14.1 µM -0.0234839930596192 0.487698154160459 no 1729 0.490632103326382 564 5286025
SGTC_2020 4017018 200 µM -0.0236863452174952 0.487619754783538 no 1730 0.490551398944652 557 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1931 st074438 57.1 µM -0.0241394603257947 0.487444201478261 no 1731 0.490370683847874 560 2787313
SGTC_1647 st011722 22.4 µM -0.0241875581259765 0.487425566779938 no 1732 0.490351501202741 564 2854783
SGTC_2729 fluphenazine 10.66 µM -0.0246527972761338 0.487245318978008 no 1733 0.490165952970555 561 3372 An atypical antipsychotic.
SGTC_2316 5844804 197.44 µM -0.0275913938041408 0.486106878982326 no 1734 0.488994022901605 567 776813
SGTC_1676 st018489 23.4 µM -0.0276516524990887 0.486083535348813 no 1735 0.488969992329226 559 3696235
SGTC_3240 9133527 49.47 µM -0.0277415022890129 0.486048728500923 no 1736 0.488934161194826 583 17617455
SGTC_1119 parthenolide 318.541 nM -0.0278690753854503 0.485999308230103 no 1737 0.488883286563108 588 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1740 st038286 13.222 µM -0.028438832851183 0.48577859373118 no 1738 0.48865607628993 564 716786
SGTC_344 k064-0035 6.43 µM -0.0284642844801701 0.48576873429757 no 1739 0.488645926667868 568 5088750
SGTC_540 1187-0821 17.3 µM -0.0291577958592465 0.485500085729988 no 1740 0.488369370467515 557 847520
SGTC_2588 indole-3-carbinol 100 µM -0.0302493022311157 0.485077277460112 no 1741 0.487934114503754 561 3712 Induces cell cycle arrest.
SGTC_545 4218-0007 221 µM -0.031066882213757 0.484760588872492 no 1742 0.487608100539449 565 2840508
SGTC_2288 7946289 167.31 µM -0.0330815251986521 0.483980260863908 no 1743 0.48680478772079 571 1246052
SGTC_2733 amorolfine 100 µM -0.0333215502481175 0.483887296429088 no 1744 0.486709084343903 563 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1502 4534-4282 27.7 µM -0.0336348327759214 0.483765959857179 no 1745 0.486584172717786 562 3278949
SGTC_2792 7535235 81.82 µM -0.0342698609823667 0.483520013498249 no 1746 0.486330979099278 563 1281891
SGTC_1313 1220-0047 237 µM -0.0346567284635321 0.483370182830329 no 1747 0.486176732932821 562 3528706
SGTC_1390 3413-2614 145 µM -0.0347523916646839 0.483333133602268 no 1748 0.486138591812841 581 3421432
SGTC_2561 acetosyringone 100 µM -0.0356654064311641 0.482979541052488 no 1749 0.48577457733073 561 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2286 7945697 125 µM -0.0367468616429693 0.482560732192735 no 1750 0.485343421833463 573 1245733
SGTC_1655 st012546 55.1 µM -0.0389776339042649 0.481696895316864 no 1751 0.484454110309435 565 720985 YLR208W SEC13
SGTC_2153 5569715 200 µM -0.0395139788816656 0.481489215521454 no 1752 0.484240304342585 570 2054701
SGTC_2096 5468907 200 µM -0.040162262024176 0.481238198514149 no 1753 0.483981881941248 564 759785
SGTC_899 1083-0020 478 µM -0.0410669978168352 0.480887894795113 no 1754 0.483621242162293 577 767123
SGTC_2349 9023730 187.07 µM -0.0414875925251119 0.48072505017216 no 1755 0.483453592034746 583 4126287
SGTC_775 4577-0580 57.3 µM -0.0417009334749788 0.480642450678091 no 1756 0.483368554902326 593 2006902
SGTC_3008 9078912 71.4286 µM -0.043645580959838 0.479889577729732 no 1757 0.482593458971052 570 16648731
SGTC_2828 7998861 71.43 µM -0.0441048113390667 0.479711796427755 no 1758 0.482410428812283 566 2988188
SGTC_1633 st005664 67.9 µM -0.0446439870516585 0.479503071138939 no 1759 0.482195540497674 574 2063822
SGTC_2208 7283366 200 µM -0.0446832011233649 0.479487890836104 no 1760 0.482179911942468 565 898663
SGTC_1809 st050081 57.6 µM -0.0448864489371996 0.479409211308154 no 1761 0.482098909069958 568 5036894
SGTC_67 0335-0847 266 µM -0.0453881353238141 0.479215006273383 no 1762 0.481898968941231 600 4552207 YOR254C SEC63
SGTC_2147 5545932 89.7195 µM -0.0460035663023084 0.47897677694445 no 1763 0.481653703711315 574 797404
SGTC_2248 tofa 1.1 µM -0.0461062981024626 0.478937010861969 no 1764 0.481612763094428 569 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2923 7992654 58.14 µM -0.0472017852391633 0.478512975810031 no 1765 0.481176202347367 565 2985126
SGTC_333 3486-0131 40.1 µM -0.0480194716991605 0.478196486120061 no 1766 0.480850362167479 568 6744690
SGTC_2408 sulbentine 18.36 µM -0.0495805769959353 0.477592290749716 no 1767 0.480228312452454 577 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2737 bleomycin 30.5 nM -0.0505614763331441 0.477212679042782 no 1768 0.479837480485796 566 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_253 dyclonine 31.25 µM -0.0514216955669047 0.476879787992127 no 1769 0.47949474853919 563 3180 An oral anasthetic.
SGTC_3267 9137951 49.47 µM -0.0521011007064032 0.476616880488409 no 1770 0.479224067961141 564 16643986
SGTC_1452 4194-0072 190 µM -0.0527602761612538 0.476361810936045 no 1771 0.478961456211767 600 1343545
SGTC_708 3448-5400 146 µM -0.0532967036433122 0.476154246154701 no 1772 0.478747753291216 567 3462195
SGTC_428 3448-4153 16.5 µM -0.0536854606266169 0.476003824907595 no 1773 0.478592883417579 581 3834874
SGTC_2001 4023502 57.655 µM -0.0537674974835045 0.475972082926709 no 1774 0.478560202647963 575 108941 YCR052W RSC6
SGTC_2482 5981709 142.65 µM -0.0544632363735136 0.475702891409127 no 1775 0.478283049109771 580 877755
SGTC_3098 9119039 49.47 µM -0.0558155663909833 0.475179687050484 no 1776 0.477744367044451 563 17161528
SGTC_839 0122-0028 230 µM -0.0558479874098457 0.475167144170697 no 1777 0.477731453072582 575 759448
SGTC_2878 9043973 25.97 µM -0.0568153653366067 0.47479290126905 no 1778 0.477346136970379 579 6465167
SGTC_2906 7926292 26.41 µM -0.057639137060226 0.474474231840134 no 1779 0.477018037306159 586 2966319
SGTC_1696 st025591 34.7925 µM -0.0579687954868902 0.474346710707808 no 1780 0.476886742153744 570 2787147
SGTC_2755 lomerizine 42.69 µM -0.0595695527159505 0.473727530487005 no 1781 0.476249234350768 581 3949 A calcium channel blocker.
SGTC_2646 retinol 96.75 µM -0.061069273925422 0.473147489014351 no 1782 0.475652019658627 581 445354 A vitamin A analog and teratogen.
SGTC_129 0088-0017 176.636 µM -0.0613363074220829 0.473044215419422 no 1783 0.475545688040956 582 182446
SGTC_3241 9133421 49.47 µM -0.0615537741890639 0.472960112796653 no 1784 0.475459094973345 576 17018221
SGTC_419 nsc-638432 893 µM -0.0623494645298055 0.472652399553252 no 1785 0.475142269035869 600 368090
SGTC_2692 st077426 47.7 µM -0.0630989104365596 0.472362585104511 no 1786 0.474843870958812 576 25238571
SGTC_748 act1.228 77.9 µM -0.0640895386599632 0.471979526735038 no 1787 0.474449465830942 586 4421505 YNR035C ARC35
SGTC_1240 0356-0016 42.1 µM -0.0642310778449 0.471924798149605 no 1788 0.474393115968605 581 4305613
SGTC_1522 st012842 45.6 µM -0.0659411758843365 0.471263601220795 no 1789 0.47371232914393 569 3491067 YOR116C RPO31
SGTC_562 3772-2733 112 µM -0.0660906319665584 0.471205818854269 no 1790 0.473652834576698 583 2876874 YIL048W NEO1
SGTC_1839 st053978 48 µM -0.0666908375316684 0.470973774877425 no 1791 0.473413914331993 578 3788398
SGTC_2900 5328528 85.29 µM -0.0671479076057541 0.47079707476116 no 1792 0.473231977587117 569 795359
SGTC_2360 9040895 200 µM -0.0683458853589941 0.470333972253108 no 1793 0.472755149131266 586 4914414
SGTC_2218 6965428 192.983 µM -0.0693904572710675 0.469930204593661 no 1794 0.472339412302885 573 675684
SGTC_16 erodoxin 22.806 µM -0.0694894649939902 0.469891935856668 no 1795 0.472300009050186 576 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2402 5553605 200 µM -0.0699991412524891 0.469694938797754 no 1796 0.47209717157186 595 6758546
SGTC_469 w7 172 µM -0.0724277892064763 0.468756334840982 no 1797 0.471130735137666 575 45115570 A P450 inhibitor.
SGTC_2780 5215298 71.43 µM -0.0736494331712351 0.468284269200963 no 1798 0.470644667965674 610 2834131
SGTC_671 0560-0003 407 µM -0.0738207045431084 0.468218090349659 no 1799 0.470576526065102 593 3238678
SGTC_2018 5133068 143 µM -0.0743840221240346 0.468000431978994 no 1800 0.470352411038981 586 785362
SGTC_473 2-arachidonoylglycerol 10 µM -0.0753538438314502 0.467625728304186 no 1801 0.46996659101675 570 5282280 An endocannabinoid.
SGTC_2189 6047310 154.431 µM -0.0756124194586366 0.467525828958744 no 1802 0.46986372772673 585 711535
SGTC_1540 guanosine 70.6 µM -0.0772013264971984 0.466912008142541 no 1803 0.469231693202997 579 6802 Guanosine is a purine nucleoside
SGTC_456 gingerol 170 µM -0.0776069527618744 0.466755320621396 no 1804 0.469070355780326 605 442793 A herb.
SGTC_3294 9122953 26.2835 µM -0.0778125190431086 0.466675915325035 no 1805 0.46898859394435 575 16459826
SGTC_704 1310-0270 142 µM -0.0796326895985284 0.465972885564646 no 1806 0.468264697613397 591 5718033
SGTC_6 0844-0013 19.835 µM -0.0803134652379985 0.465709967295195 no 1807 0.467993974549089 589 1584900
SGTC_1938 st074717 56.4 µM -0.0810138906173829 0.465439475839199 no 1808 0.467715452850876 580 17250979
SGTC_2465 5809242 33.21 µM -0.082079370762026 0.465028037576954 no 1809 0.467291798755321 581 2731748
SGTC_2150 5556613 200 µM -0.0834697719623699 0.464491186393914 no 1810 0.466739005987373 583 743190
SGTC_2072 5231554 129 µM -0.0854591305254801 0.463723182970388 no 1811 0.465948192839677 586 789545
SGTC_1283 0922-0125 16.4 µM -0.0855559365246898 0.463685813878003 no 1812 0.46590971376168 584 3360884
SGTC_468 gf-109203x 121 µM -0.0861818822148901 0.463444193808234 no 1813 0.465660916507075 585 2396 A protein kinase C inhibitor.
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.086593939317016 0.463285143807708 no 1814 0.465497141764736 589 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2584 androsterone 48.74 µM -0.0875590915263493 0.462912627535224 no 1815 0.465113558740856 594 2754130 A steroid.
SGTC_2932 9016711 44.54 µM -0.0885595777488331 0.462526507855913 no 1816 0.464715967046347 606 7117328
SGTC_2298 7976326 193.81 µM -0.0905712529474845 0.46175024520007 no 1817 0.463916637424387 581 2235818
SGTC_3040 9091894 49.47 µM -0.0906411874439724 0.461723261569247 no 1818 0.463888851883803 575 25236966
SGTC_2807 7945238 51.95 µM -0.0908887587477766 0.461627739703468 no 1819 0.463790491220516 608 17148797
SGTC_895 0964-0006 13.7 µM -0.0915168965576446 0.461385391610226 no 1820 0.46354094053137 588 6738897
SGTC_62 0180-0423 3.232 µM -0.0936564537144451 0.46056001592957 no 1821 0.462691031533849 586 30102 YGL099W LSG1
SGTC_803 4488-1585 147 µM -0.0936991418200355 0.460543549881579 no 1822 0.462674076003995 612 747204
SGTC_1900 st060200 72.8 µM -0.0946514764546896 0.460176224266259 no 1823 0.462295830519417 585 688945
SGTC_1170 0310-0127 64.8 µM -0.0962868638829898 0.459545517372516 no 1824 0.461646371856502 612 774975
SGTC_107 0358-0022 2.6945 µM -0.0964419216454356 0.459485722734135 no 1825 0.461584799308238 621 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_543 3844-1095 191 µM -0.0972225901953074 0.459184688913333 no 1826 0.461274814321466 595 4230703
SGTC_2427 5545055 42.75 µM -0.0976639249108869 0.459014516051797 no 1827 0.461099581158954 615 5372858
SGTC_487 nimodipine 119 µM -0.0978284192294858 0.45895109112565 no 1828 0.461034270167743 582 4497 L-type voltage-gated calcium channels inhibitor
SGTC_3006 9075424 71.4286 µM -0.0980073838836779 0.458882087984145 no 1829 0.460963215053597 585 7465181
SGTC_2089 5281248 129.67 µM -0.0981881098770653 0.458812406982876 no 1830 0.460891461892051 585 2737878
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.0994139452916249 0.458339805442985 no 1831 0.460404805436106 598 6857784
SGTC_1222 0366-0074 1.18 µM -0.0994549912181461 0.458323981847567 no 1832 0.460388511232153 609 286520
SGTC_102 gallobenzophenone 83.616 µM -0.100182555963653 0.458043509696107 no 1833 0.460099697329996 592 70837
SGTC_2791 5663188 71.43 µM -0.100559569436699 0.457898181313379 no 1834 0.459950046435707 597 54690634
SGTC_1465 k213-0056 144 µM -0.100819824503922 0.457797863385465 no 1835 0.459846744673576 590 24048857 YMR208W ERG12
SGTC_36 0335-0881 14.2 µM -0.101355637300498 0.457591337437342 no 1836 0.459634075681268 592 23828853
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.101441859002175 0.457558104848507 no 1837 0.459599854577637 643 6710655
SGTC_882 0843-0131 351 µM -0.102238690285211 0.457250994777154 no 1838 0.459283609117013 615 5425421
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.103850168695254 0.456629986358429 no 1839 0.458644126405511 609 77254
SGTC_947 3447-0010 211 µM -0.10494831184596 0.456206860297647 no 1840 0.458208411647706 606 748350
SGTC_3002 9075603 71.4286 µM -0.105176332264774 0.456119007851505 no 1841 0.458117945330121 587 20105405
SGTC_2803 7707263 71.43 µM -0.105600104190205 0.455955741331706 no 1842 0.457949821041364 602 2199229
SGTC_3020 9089140 49.47 µM -0.105647220634069 0.455937589248266 no 1843 0.457931128859498 591 17217859
SGTC_806 3966-4455 5.86 µM -0.105718174551969 0.455910253711974 no 1844 0.457902979976514 633 714982
SGTC_856 0433-0016 11.3 µM -0.10602658663351 0.455791438039628 no 1845 0.457780628996691 602 3911780
SGTC_3206 9114350 49.47 µM -0.107337451270767 0.455286472028143 no 1846 0.457260637168548 610 17087243
SGTC_71 0417-1750 47.813 µM -0.107798270805244 0.45510897409555 no 1847 0.457077857297801 580 6811472
SGTC_795 0685-0265 78 µM -0.108410771155855 0.454873065800157 no 1848 0.456834928673639 597 302754
SGTC_1064 honokiol 6.76 µM -0.109441584900363 0.454476077487701 no 1849 0.456426125918096 607 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2167 5876490 200 µM -0.109835694090567 0.454324309644234 no 1850 0.456269841248696 596 686534
SGTC_510 ag-490 170 µM -0.111349011815111 0.453741606989771 no 1851 0.455669795604243 594 5328779
SGTC_2128 5255449 168.493 µM -0.113617119638376 0.452868459397399 no 1852 0.454770657861955 598 736008
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.113640716495311 0.452859376566753 no 1853 0.454761304655474 610 5377381
SGTC_424 splitomicin 100 mM -0.113976857774862 0.452729992764794 no 1854 0.454628069348737 631 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2957 9076800 11.52 µM -0.114294816132034 0.452607612351811 no 1855 0.454502045849692 615 16459615
SGTC_3004 9076122 71.4286 µM -0.114512158001148 0.452523961258277 no 1856 0.454415904552943 620 44782551
SGTC_2312 7706453 155.7 µM -0.114556941318554 0.452506725202432 no 1857 0.454398155394983 611 976098
SGTC_3237 9133362 49.47 µM -0.114764101180761 0.452426995361362 no 1858 0.454316052052837 615 43845137
SGTC_889 0919-1524 82.7 µM -0.115020666182163 0.45232825357012 no 1859 0.454214370755741 616 3905452
SGTC_816 0325-0417 81.3 µM -0.115175702110558 0.452268587759774 no 1860 0.454152928699486 602 68101
SGTC_3293 9120939 62.045 µM -0.115536220287821 0.452129845966724 no 1861 0.454010056525773 609 934087
SGTC_225 nsc-122657 1.016 µM -0.116331712023542 0.451823729679779 no 1862 0.453694826832698 637 275685
SGTC_1539 benzyladenosine 56 µM -0.117389909464436 0.451416565003844 no 1863 0.453275539933872 603 92208 A nucleotide analog.
SGTC_1670 st016595 4.04 µM -0.118142361597868 0.451127073606141 no 1864 0.452977429382123 592 597879
SGTC_1153 4055-0057 267 µM -0.118204403767047 0.451103205239977 no 1865 0.452952850360628 600 882706
SGTC_369 0957-0393 4.5 µM -0.119165715598271 0.450733399700513 no 1866 0.452572034025199 648 6997992
SGTC_2513 baicalein 25.65 µM -0.120058173547244 0.450390119724307 no 1867 0.45221853266894 628 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1882 5615643 20 µM -0.120262222154963 0.450311638539131 no 1868 0.452137714607994 599 2253075
SGTC_794 k038-0031 316 µM -0.121013695090034 0.45002262376088 no 1869 0.45184009390142 592 6624242
SGTC_2531 methyl deoxycholate 70.07 µM -0.121762523333555 0.449734652489575 no 1870 0.451543547545466 621 16667744 Haematoxylin.
SGTC_119 0121-0043 24.815 µM -0.122275776237904 0.449537289941676 no 1871 0.45134030789353 604 1092378
SGTC_2144 5628481 200 µM -0.122330595514663 0.44951621087171 no 1872 0.45131860112057 587 2818399
SGTC_187 1488-2104 32.728 µM -0.122494975096884 0.449453004603981 no 1873 0.451253512658481 593 2852859
SGTC_2065 5221596 34.26 µM -0.122579137702578 0.449420643391408 no 1874 0.451220187770284 595 788581
SGTC_2667 digitoxin 100 µM -0.123273459635344 0.449153683765578 no 1875 0.450945278328021 600 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_606 k015-0008 38.6 µM -0.123510957469065 0.449062373573464 no 1876 0.45085124896104 622 1970475
SGTC_2321 7390090 138.78 µM -0.123758746513584 0.448967109621153 no 1877 0.450753148071599 612 649046
SGTC_86 0417-1630 471.922 µM -0.123763296850891 0.448965360244764 no 1878 0.450751346599011 599 3634867
SGTC_2570 licareol 100 µM -0.123880083647496 0.448920461920646 no 1879 0.450705111206245 639 443158
SGTC_3069 9117009 49.47 µM -0.123986881571976 0.44887940436021 no 1880 0.450662830950708 596 41904981
SGTC_406 estrone 100 µM -0.124694005697411 0.448607570292606 no 1881 0.450382901561436 596 5870 A steroid.
SGTC_165 k038-0023 64.381 µM -0.124725878862336 0.448595318114217 no 1882 0.450370284504637 607 46368543
SGTC_376 3970-0862 59.1 µM -0.1249944762664 0.448492070093197 no 1883 0.450263961672573 642 3135186
SGTC_2416 tofa 880 nM -0.126036532224917 0.44809154005287 no 1884 0.449851503304325 604 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_860 0443-0016 25.1 µM -0.126327204563645 0.447979825144061 no 1885 0.449736461315678 609 5337942
SGTC_3316 9136639 10.545 µM -0.127161636080959 0.447659148709391 no 1886 0.449406234400598 602 4903665
SGTC_3081 9117243 49.47 µM -0.12749603401758 0.447530647407551 no 1887 0.449273905981389 613 45595589
SGTC_1511 0906-3109 28.5 µM -0.127592968268396 0.447493398872274 no 1888 0.449235548078145 610 2882180
SGTC_2686 alizarin 95.37 µM -0.12787618471979 0.44738457107809 no 1889 0.449123479066862 606 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_3080 9117754 49.47 µM -0.129250717620269 0.446856454133496 no 1890 0.44857963293961 585 9550191
SGTC_2582 agaric acid 100 µM -0.129294266396017 0.446839723550818 no 1891 0.448562404054026 608 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1332 1480-0653 17.5 µM -0.132178387729489 0.445731912937974 no 1892 0.447421597606631 590 5749438
SGTC_810 3825-7150 143 µM -0.132346690131367 0.445667279836886 no 1893 0.447355039380296 602 22330411 YGL099W LSG1
SGTC_3124 9127567 49.47 µM -0.132633183108331 0.445557261380488 no 1894 0.447241743965864 633 17592030
SGTC_2187 6125751 200 µM -0.132921550760434 0.445446527248732 no 1895 0.447127711546925 610 874498
SGTC_1472 k841-0093 193 µM -0.133952939115602 0.445050505603257 no 1896 0.446719894048998 620 X1472
SGTC_2557 derrustone 83.84 µM -0.134661332518364 0.444778535901088 no 1897 0.446439823414928 664 629853 An antioxidant.
SGTC_1423 4048-0112 5.59 µM -0.134857657269543 0.444703166580941 no 1898 0.446362209122861 608 X1423
SGTC_780 0109-0199 192 µM -0.135099064109794 0.444610492930608 no 1899 0.446266775063653 604 610414
SGTC_3222 9128301 49.47 µM -0.13521765485502 0.444564968248737 no 1900 0.446219894366078 602 4911358
SGTC_14 0354-0009 295 µM -0.135261300475134 0.444548213727638 no 1901 0.446202640788035 607 1713507
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.135603741785337 0.444416762049957 no 1902 0.446067273631606 620 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_763 3453-1109 128 µM -0.136554462928375 0.44405184433715 no 1903 0.445691486267157 590 1560353
SGTC_1078 idebenone 36.1 µM -0.136675190505442 0.444005508551712 no 1904 0.445643770292567 603 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2318 6029776 164 µM -0.137420808926771 0.443719353843206 no 1905 0.445349091967841 621 818325
SGTC_1819 st053448 58.6 µM -0.138834957726702 0.443176710127202 no 1906 0.444790284605126 594 2857616
SGTC_2766 oltipraz 83.91 µM -0.13933257301095 0.442985788181701 no 1907 0.444593675687353 601 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_145 3737-0113 38.366 µM -0.139363803137042 0.442973806441641 no 1908 0.444581337048401 609 6849351
SGTC_2768 sulfasalazine 50.2 µM -0.140506079233843 0.442535597088896 no 1909 0.44413007480267 655 5384001 An antioxidant and salicylic acid derivative.
SGTC_2063 5246145 200 µM -0.141398492107512 0.442193291205916 no 1910 0.443777572713414 635 711240
SGTC_922 1866-0035 480 µM -0.141475099174865 0.442163908776743 no 1911 0.443747315076319 641 3156169
SGTC_1031 k035-0009 16 µM -0.142084652260728 0.441930127725007 no 1912 0.443506570450547 654 5180959
SGTC_747 3448-8087 38.7 µM -0.142887014130375 0.441622429832904 no 1913 0.443189707277693 643 5168703
SGTC_538 2922-0838 53.3 µM -0.143302068751426 0.441463274277205 no 1914 0.443025811034454 619 777039
SGTC_3343 9148379 18.9835 µM -0.143784166515359 0.441278422432785 no 1915 0.442835453118701 615 1955036
SGTC_3347 9188721 44.724 µM -0.14486640134616 0.440863505311622 no 1916 0.442408177195335 612 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.145044914678974 0.440795071456103 no 1917 0.44233770496853 643 5393153
SGTC_1770 st043884 66.3 µM -0.146528729397125 0.440226313303637 no 1918 0.441752005947758 609 670149
SGTC_1915 st067105 30.6 µM -0.148704988012756 0.439392359196996 no 1919 0.440893212569703 629 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1218 1348-1416 30.7 µM -0.149034804920635 0.439265994942794 no 1920 0.440763084643383 609 6787668
SGTC_2819 7996655 46.38 µM -0.151007419614823 0.438510347726027 no 1921 0.439984931506471 629 6456960
SGTC_3120 9124077 49.47 µM -0.153803909706013 0.43743948418847 no 1922 0.438882175510598 624 18774327 YGL155W CDC43
SGTC_2014 4013930 200 µM -0.154079910427005 0.437333819588888 no 1923 0.438773364134806 642 64556
SGTC_3221 9128209 49.47 µM -0.154220315515237 0.437280068373607 no 1924 0.438718012174824 618 16460723
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.15644869192687 0.436427135687868 no 1925 0.437839679525442 617 551469
SGTC_1806 st050005 60.3 µM -0.156792679518788 0.436295497330295 no 1926 0.43770412119521 619 5194765
SGTC_2319 6033012 152.6 µM -0.156852778005766 0.436272499357734 no 1927 0.43768043838568 607 847246
SGTC_3236 9132701 49.47 µM -0.156942462020432 0.436238180250329 no 1928 0.437645097321494 645 24282524
SGTC_792 4534-1957 155 µM -0.157048141498791 0.436197740823888 no 1929 0.437603453690979 609 1717904
SGTC_2284 7945075 39.21 µM -0.157820547523721 0.435902191355353 no 1930 0.437299103492545 637 1245402
SGTC_3346 9158254 43.5805 µM -0.158249013296408 0.435738260838795 no 1931 0.437130291635774 607 17639500
SGTC_2470 5664817 21.68 µM -0.158275537091455 0.435728113227627 no 1932 0.43711984186284 621 2859561
SGTC_3320 9137005 35.139 µM -0.158352641069824 0.435698614627736 no 1933 0.437089464895423 606 4908713
SGTC_617 3770-0098 35 µM -0.158978979403764 0.43545900208036 no 1934 0.43684271759793 631 5962639
SGTC_697 0508-1955 564 µM -0.15926445208022 0.435349799255973 no 1935 0.43673026318472 626 6243113
SGTC_1881 5652484 16 µM -0.159540486013524 0.435244211754097 no 1936 0.436621531776654 658 2255129
SGTC_1747 st037496 66.6 µM -0.159816797385488 0.435138522751325 no 1937 0.436512695879345 606 723305
SGTC_2537 larixol 68.93 µM -0.160633859764988 0.434826023815815 no 1938 0.436190892477573 614 6708759
SGTC_463 ikarugamyin 104 µM -0.160802632208022 0.434761479087739 no 1939 0.436124426007904 613 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_552 k242-0005 476 µM -0.160995164374867 0.434687849899144 no 1940 0.43604860461525 632 4088318
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.161638910131105 0.434441681640898 no 1941 0.435795107177261 618 140250 A respiratory chain inhibitor.
SGTC_656 4090-1979 187 µM -0.161766207914076 0.434393005999157 no 1942 0.435744982337092 620 22330961
SGTC_2701 st077767 14.721 µM -0.163166635998234 0.433857581454334 no 1943 0.435193617370404 638 5721188
SGTC_3344 9148862 3.898 µM -0.163531691259081 0.433718030067471 no 1944 0.435049911487869 651 4905352
SGTC_2178 5812956 200 µM -0.163631089207172 0.433680034177953 no 1945 0.435010784459091 612 5403383
SGTC_2516 gossypol 71.55 µM -0.164776195239448 0.433242349888675 no 1946 0.434560070675489 642 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3209 9113616 49.47 µM -0.166467466680533 0.432596059268815 no 1947 0.433894541875579 648 16649353
SGTC_2206 7254556 146.969 µM -0.167238002456807 0.432301671800016 no 1948 0.43359139191228 618 4398905
SGTC_2471 5466956 24.79 µM -0.16838763151196 0.431862519550572 no 1949 0.433139168898672 621 724419
SGTC_3171 9103192 49.47 µM -0.16845423607792 0.431837079531709 no 1950 0.433112971718071 608 13018434
SGTC_2487 5918373 44.05 µM -0.169042927785606 0.431612237457716 no 1951 0.432881437877841 611 2876279
SGTC_1209 2323-2347 50.3 µM -0.16923202584664 0.431540018953232 no 1952 0.432807070048702 610 5412760
SGTC_684 1140-0066 328 µM -0.169491061198145 0.431441094389176 no 1953 0.432705201388086 645 6813534
SGTC_610 4215-0184 155 µM -0.170314901346717 0.431126501747898 no 1954 0.432381246444068 621 5605015
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.170504096923404 0.431054261447364 no 1955 0.432306856331013 626 1377
SGTC_2005 4024620 188 µM -0.171399074931758 0.430712564462824 no 1956 0.431954991056901 624 236743
SGTC_3135 9127742 49.47 µM -0.172072992113944 0.43045530133078 no 1957 0.431690072606553 622 3643468
SGTC_2533 agelasine 13.65 µM -0.172481146214775 0.430299505724738 no 1958 0.431529641185678 626 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2429 5902844 64.44 µM -0.175400894700932 0.429185332773722 no 1959 0.43038231880748 640 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_193 1273-0060 1.558 µM -0.175664396453099 0.429084808394746 no 1960 0.430278803900957 650 2847393 YHR072W ERG7
SGTC_863 0466-0191 129 µM -0.176325026456785 0.428832802141954 no 1961 0.430019300888636 639 765160 YPR165W RHO1
SGTC_255 tunicamycin 200.472 nM -0.176597410385511 0.428728906047672 no 1962 0.429912314164131 648 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2868 9035608 32.47 µM -0.17686604998074 0.428626443001263 no 1963 0.429806803176226 609 6462614
SGTC_1408 3909-7976 48.8 µM -0.17848846394847 0.428007733228747 no 1964 0.429169690083496 629 24152374
SGTC_2786 7743617 45.45 µM -0.179681662612141 0.427552818133438 no 1965 0.428701245124123 646 583674
SGTC_1943 st076331 65.2 µM -0.182313411997263 0.426549787078357 no 1966 0.427668386910396 620 24208415
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.183537290799823 0.426083495039951 no 1967 0.427188230932516 620 1273210
SGTC_2710 st078562 53.7235 µM -0.183813310353261 0.425978347150728 no 1968 0.427079956952721 658 17250908
SGTC_2669 eugenol 100 µM -0.18455076790437 0.425697443230891 no 1969 0.426790702007719 651 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1764 st044502 93.5 µM -0.184722117390149 0.425632180132044 no 1970 0.426723498771462 623 8407
SGTC_236 1509-0011 5.31 µM -0.185054207174411 0.42550570053314 no 1971 0.426593259278002 656 3107280
SGTC_1310 1188-0297 994 nM -0.187410729464609 0.424608417203875 no 1972 0.425669305374276 633 1588352
SGTC_2261 9010538 184.68 µM -0.187532528933646 0.424562050694133 no 1973 0.425621560837071 702 6457250
SGTC_1192 1488-0095 21.4 µM -0.187629755667376 0.424525039259821 no 1974 0.425583449422361 656 915875
SGTC_952 1185-0122 232 µM -0.187925978321345 0.424412279878854 no 1975 0.425467338892564 618 678600
SGTC_2841 9004761 38.96 µM -0.188441194311622 0.424216173779632 no 1976 0.42526540484712 625 2991039
SGTC_2380 9035439 200 µM -0.189819679140708 0.423691574986835 no 1977 0.424725217264517 629 6462575
SGTC_1659 st012954 42.1 µM -0.190826767453232 0.423308400978105 no 1978 0.424330658318411 661 24207262
SGTC_283 0987-0079 11.7 µM -0.192025202286653 0.422852518533793 no 1979 0.423861232101298 632 411556
SGTC_3315 9136395 68.55 µM -0.193385455962463 0.422335205680835 no 1980 0.423328552453048 671 16876844
SGTC_1439 4092-1168 46 µM -0.193520779301792 0.422283748692097 no 1981 0.423275567051528 630 2886240
SGTC_2899 9053889 58.44 µM -0.194499381252338 0.421911672743696 no 1982 0.422892440082976 628 6470052
SGTC_2771 fluoxetine 41.05 µM -0.195606227334134 0.421490920877211 no 1983 0.422459192867434 641 3386 A selective serotonin reuptake inhibitor.
SGTC_45 0kpi-0036 14.9 µM -0.196356448520897 0.421205785846096 no 1984 0.422165590846334 629 2795021
SGTC_3003 9075612 71.4286 µM -0.197227221839978 0.420874884634095 no 1985 0.421824864513328 662 6501993
SGTC_2940 9060638 45.86 µM -0.197451157408577 0.420789796253639 no 1986 0.421737249842668 640 4027022
SGTC_175 3793-3120 23.7 µM -0.197469634223571 0.420782775817897 no 1987 0.421730020971695 687 5322297
SGTC_1049 3226-0134 66 µM -0.19939066364149 0.42005300091069 no 1988 0.420978581596965 614 5702385
SGTC_3060 1327-0027 12.5 µM -0.199889179749742 0.419863665719108 no 1989 0.420783626490264 623 16000455 YPR107C YTH1
SGTC_661 1304-0007 33.6 µM -0.199948328437667 0.419841202422925 no 1990 0.420760496452231 635 3117130
SGTC_2399 5884133 200 µM -0.201343360341567 0.419311477619779 no 1991 0.420215050033827 649 722445
SGTC_1017 4239-0030 168 µM -0.20189941072152 0.419100373559985 no 1992 0.41999768138287 620 1149593
SGTC_137 0438-0332 85.389 µM -0.202047332763651 0.4190442190001 no 1993 0.419939860486624 672 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2812 7970281 58.44 µM -0.204734685339154 0.418024327297318 no 1994 0.418889709696633 663 2233435
SGTC_842 0271-0008 11.1 µM -0.206392235939052 0.417395535609858 no 1995 0.418242267551513 624 1221709
SGTC_2029 5175081 200 µM -0.206910811382643 0.41719885735135 no 1996 0.418039756481742 645 1380876
SGTC_1578 josamycin 24.2 µM -0.208473915261999 0.416606150049396 no 1997 0.417429473899044 672 5282165 A P450 substrate.
SGTC_3043 9092303 49.47 µM -0.209210475839139 0.416326922117092 no 1998 0.417141967419826 648 25236084
SGTC_977 1348-1378 135 µM -0.209291719902366 0.416296125316382 no 1999 0.417110257606357 630 X977
SGTC_2017 5132927 60.65 µM -0.209902718869173 0.416064533320519 no 2000 0.416871800076422 652 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1142 3253-1408 9.78 µM -0.211705767179608 0.415381279177049 no 2001 0.416168294262898 640 256655
SGTC_1361 1608-0041 5.61 µM -0.21264378287798 0.415025924877253 no 2002 0.415802409272887 635 X1361
SGTC_2115 tiliquinol 12.7705 µM -0.212801323229014 0.414966249699392 no 2003 0.415740965797916 672 71208 A bioactive hydroxyquinoline.
SGTC_488 nitrendipine 139 µM -0.213759444639306 0.414603362341383 no 2004 0.415367326206971 621 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_611 3453-1652 23.7 µM -0.213924169047997 0.414540980497723 no 2005 0.415303096159287 641 1560575
SGTC_841 0251-0215 91.2 µM -0.214201896245651 0.414435808891997 no 2006 0.415194808705414 660 3888614
SGTC_2555 cholic acid 100 µM -0.215427079294362 0.413971921642041 no 2007 0.414717179689227 645 6708657 Influences liver metabolism.
SGTC_2893 9048488 25.97 µM -0.216625042588632 0.413518456553745 no 2008 0.41425028397659 624 6467338
SGTC_50 0929-0078 56.389 µM -0.221004513780013 0.411861680940252 no 2009 0.412544459194613 648 1377751
SGTC_3238 9133470 49.47 µM -0.222460661257938 0.411311159466892 no 2010 0.411977646884603 644 3534688
SGTC_674 0498-0004 451 µM -0.222557369269324 0.411274603518975 no 2011 0.411940009321051 653 4231473
SGTC_2731 amoxapine 43.43 µM -0.223147447471278 0.411051568709942 no 2012 0.411710375736287 637 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1010 4112-3296 15.2 µM -0.223818260978982 0.410798052896528 no 2013 0.411449360097991 642 704384
SGTC_2164 5685496 200 µM -0.226316618745898 0.409854194774403 no 2014 0.410477586896509 656 759046
SGTC_614 0462-0418 107 µM -0.226368490069186 0.409834603747562 no 2015 0.410457416579063 639 5188303
SGTC_128 0906-2981 13.371 µM -0.227065298730898 0.40957145132678 no 2016 0.410186483451502 664 6740226
SGTC_951 1171-0579 82.7 µM -0.227589664021293 0.409373449650033 no 2017 0.409982628009594 659 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1121 fusaric acid 630.51 nM -0.228314198000025 0.409099901810634 no 2018 0.409700993809852 640 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2297 7971671 152.32 µM -0.229457133146047 0.408668476621416 no 2019 0.409256817306588 666 909016
SGTC_673 1082-0474 110 µM -0.229616067811747 0.40860849210158 no 2020 0.409195060070606 665 3098046
SGTC_462 ag-879 158 µM -0.232033330785307 0.407696442550139 no 2021 0.408256062969656 678 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2012 4023501 200 µM -0.232837403958186 0.407393170928596 no 2022 0.407943833431233 685 3477460
SGTC_309 k408-0051 1.48 µM -0.233209699330279 0.407252771373817 no 2023 0.407799287253767 651 3640463
SGTC_2829 7992743 58.44 µM -0.234468790385214 0.406778032955964 no 2024 0.407310529799547 642 16462845
SGTC_2049 5262831 67.185 µM -0.234795481635453 0.406654876854042 no 2025 0.40718373742799 669 763417
SGTC_1630 st005209 31.3 µM -0.235053986905421 0.40655743205215 no 2026 0.40708341565709 631 3367314
SGTC_730 1436-0052 41.2 µM -0.235323885379812 0.406455698701469 no 2027 0.406978678869967 629 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1548 st061468 90.8 µM -0.236781544735635 0.40590636965963 no 2028 0.406413134819881 653 390799
SGTC_185 k048-0037 25.491 µM -0.238274386934219 0.405343973693602 no 2029 0.405834142791442 636 6827589
SGTC_2677 mitomycin C 100 µM -0.239156333333627 0.4050118112229 no 2030 0.405492180590578 651 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2066 5222451 176 µM -0.23967175355502 0.404817723089537 no 2031 0.405292367087665 668 2281147
SGTC_1573 oleylamine 1.06 µM -0.240440969272904 0.404528108547373 no 2032 0.404994210335314 676 5356789 An amine of the fatty acid oleic acid.
SGTC_2003 4023581 200 µM -0.242169632444576 0.403877447089513 no 2033 0.404324362295064 659 16641307
SGTC_3239 9133757 49.47 µM -0.242746375471468 0.403660422532695 no 2034 0.404100939634026 669 17036923
SGTC_512 prima-1 270 µM -0.242784683391066 0.403646008567573 no 2035 0.404086100756917 657 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1355 1499-0035 1.68 µM -0.242884891337539 0.403608304350008 no 2036 0.404047285065181 659 1548538
SGTC_2435 5706476 10.6 µM -0.244172571029847 0.403123882135284 no 2037 0.403548584687447 626 5725375
SGTC_340 k038-0059 454 µM -0.244459917093575 0.403015803449065 no 2038 0.403437320934396 645 23733424
SGTC_1492 4158-0558 28.5 µM -0.245950420488988 0.402455303568946 no 2039 0.402860306210878 668 3967268
SGTC_1570 verbenone 133 µM -0.246180871290698 0.402368661016277 no 2040 0.402771111235182 689 29025 A natural terpanoid with antifungal properties.
SGTC_2274 7947094 46.08 µM -0.246574948388171 0.402220511025464 no 2041 0.402618597144071 646 2971028
SGTC_1300 1094-0077 113 µM -0.246634089135538 0.402198278767392 no 2042 0.402595710014527 642 5532636
SGTC_2935 9038016 29.96 µM -0.246974743495301 0.402070225748989 no 2043 0.402463885235678 663 6463195
SGTC_1115 galangin 695.678 nM -0.247402521662703 0.401909437512245 no 2044 0.402298361415943 696 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1276 0871-0068 94.2 µM -0.248147178041667 0.401629584427915 no 2045 0.402010267036547 647 3414906
SGTC_1201 1889-3372 45.9 µM -0.248160378396763 0.401624623990218 no 2046 0.402005160532409 652 5392199
SGTC_3260 9137109 49.47 µM -0.248248223138144 0.401591614042105 no 2047 0.401971178574542 666 17478346
SGTC_3340 9146634 11.102 µM -0.248564751264413 0.401472676184859 no 2048 0.401848738628224 673 4907387
SGTC_2186 6124449 200 µM -0.251978330739622 0.400190579853353 no 2049 0.400528906530534 659 3834182 YLR033W RSC58
SGTC_3061 glucosamine 200 µM -0.253794477137135 0.399508895927033 no 2050 0.399827170195197 648 91431 and experimental redox chemotherapeutic
SGTC_3170 9103054 49.47 µM -0.255844773276648 0.398739692832315 no 2051 0.399035350029659 686 16432970
SGTC_3183 9108214 49.47 µM -0.256625094542328 0.398447045305029 no 2052 0.398734100481061 670 4974831
SGTC_3134 9127454 49.47 µM -0.257002592119779 0.398305491109786 no 2053 0.398588386023363 664 24262820
SGTC_1624 st003710 6.25 µM -0.257328573363269 0.39818326529637 no 2054 0.398462568297608 696 24207033
SGTC_1085 doxorubicin 7.67 µM -0.257385969574525 0.398161745771262 no 2055 0.398440416395224 679 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1976 st070609 63.5 µM -0.25797687485879 0.397940216048864 no 2056 0.398212377242522 638 682556
SGTC_1691 st019933 84.6 µM -0.258560060027204 0.39772161284625 no 2057 0.397987351478612 681 6176082
SGTC_586 0957-0265 8.15 µM -0.260151539452 0.397125220611263 no 2058 0.397373441703434 671 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1401 3807-4679 7.6 µM -0.260396653895298 0.397033387570875 no 2059 0.397278911879798 647 3291456
SGTC_3112 9123419 49.47 µM -0.260467875329922 0.397006705264937 no 2060 0.39725144604653 671 17015854
SGTC_1478 0453-0656 35.7 µM -0.260597837759472 0.396958017551417 no 2061 0.397201328649863 669 5258496
SGTC_273 hydroxyurea 18.1 mM -0.260701885873855 0.396919039253125 no 2062 0.397161205810931 653 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1557 sumaresinolic acid 42.3 µM -0.262774258712474 0.396142906050921 no 2063 0.396362288524157 670 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_132 0417-1715 25.805 µM -0.26281882827048 0.396126218624475 no 2064 0.39634511134817 687 6769098
SGTC_2296 7971656 126.45 µM -0.262989954053908 0.396062148657775 no 2065 0.396279161078516 652 666570
SGTC_2874 9043904 71.43 µM -0.263217879833903 0.395976816975581 no 2066 0.396191325233154 664 4463428
SGTC_114 0364-0001 490.298 µM -0.264184138221685 0.395615121051196 no 2067 0.3958190164396 670 4003655
SGTC_2861 9024595 19.48 µM -0.264218766149886 0.395602160573517 no 2068 0.395805675722522 642 16482810
SGTC_339 3091-4833 71.4 µM -0.264604108346724 0.395457943193895 no 2069 0.395657227456671 658 3240077
SGTC_1664 st014217 9.02 µM -0.265037384146093 0.395295803380226 no 2070 0.39549033144715 675 3982782
SGTC_920 mycophenolic acid 780.421 nM -0.265382197785075 0.395166780692529 no 2071 0.395357524381636 659 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1328 1441-0025 69.2 µM -0.265736003683745 0.395034405218865 no 2072 0.395221266524645 670 4562601
SGTC_2424 5537928 59.2 µM -0.266173046360693 0.394870903666798 no 2073 0.39505297017625 681 5382802
SGTC_3167 9103034 49.47 µM -0.268566049453856 0.39397598883676 no 2074 0.394131820637997 657 5127859
SGTC_3268 9137683 49.47 µM -0.268902414809799 0.393850242543889 no 2075 0.394002389322686 677 1953228
SGTC_1981 st071826 47 µM -0.270822740397286 0.393132563378723 no 2076 0.39326368447542 646 11838600
SGTC_934 2950-0684 338 µM -0.271024988504991 0.393056998716695 no 2077 0.393185906616985 701 1121253
SGTC_906 1165-0455 526 µM -0.271943857710441 0.392713738294399 no 2078 0.392832593978022 692 3252859
SGTC_1831 st055328 12 µM -0.272371467864111 0.392554025119003 no 2079 0.392668204498463 688 1103068
SGTC_896 0964-0007 44.5 µM -0.272753656501845 0.392411292274167 no 2080 0.392521292965536 658 6756758
SGTC_2484 5809818 12.04 µM -0.272767863160505 0.392405986909137 no 2081 0.392515832287169 662 2870548
SGTC_1451 4152-0210 104 µM -0.273574659759246 0.392104727901742 no 2082 0.392205754943215 710 659563
SGTC_2344 7990960 76.95 µM -0.274136562505897 0.391894950799877 no 2083 0.391989838435845 669 140813
SGTC_2970 9090938 41.86 µM -0.2741832589137 0.391877518881346 no 2084 0.39197189639016 660 17217104
SGTC_921 1561-0023 372 µM -0.276833209555491 0.39088864048317 no 2085 0.390954089894785 669 24050882
SGTC_1827 berberine 7.24 µM -0.277258005179032 0.390730185502044 no 2086 0.390791001477178 685 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_956 1185-0240 191 µM -0.278081527845232 0.390423051202082 no 2087 0.390474887680584 673 1416193
SGTC_1177 0983-0204 23.6 µM -0.27825597897204 0.390357998101009 no 2088 0.390407932920764 653 766818
SGTC_1352 1496-0991 99 µM -0.279620526609997 0.389849262172644 no 2089 0.389884328554599 695 3000039
SGTC_449 xestospongin c 11.1929 µM -0.280470224829194 0.389532569644576 no 2090 0.389558383121884 701 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1098 clofazimine 15.1 µM -0.28067201298089 0.389457371594467 no 2091 0.389480988307406 659 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2336 9001819 198.65 µM -0.281148550570016 0.389279802291542 no 2092 0.389298232153722 686 2989602
SGTC_1311 1190-0148 100 µM -0.281290004518732 0.389227097615172 no 2093 0.389243988091282 667 1961333
SGTC_3266 9136860 49.47 µM -0.283041739468774 0.388574583530544 no 2094 0.388572420589162 677 4871271 YPR165W RHO1
SGTC_3042 9091578 49.47 µM -0.283317458116189 0.388471908045876 no 2095 0.388466747837142 648 25236497
SGTC_1260 0700-1617 7.75 µM -0.285542172176266 0.387643727479105 no 2096 0.387614399924711 646 2853078
SGTC_1319 1306-0155 43.7 µM -0.285973087211485 0.387483372350388 no 2097 0.387449367216666 653 3122360
SGTC_227 fluconazole 33.516 µM -0.286007601374506 0.387470529527543 no 2098 0.387436149792253 677 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2941 9056145 11.23 µM -0.28609845562415 0.387436722979435 no 2099 0.387401357187081 700 2119517
SGTC_162 k030-0015 37.8 µM -0.286654629323225 0.387229791307887 no 2100 0.387188390373924 673 1809920 YMR134W ERG29
SGTC_1509 1326-1131 80 µM -0.287128224869437 0.38705360916987 no 2101 0.387007070670185 645 768313
SGTC_909 3448-9333 149 µM -0.288513269577287 0.386538492747727 no 2102 0.386476937255676 670 3344074
SGTC_618 k072-0232 33.2 µM -0.290083331092562 0.385954807858406 no 2103 0.385876243829213 709 5872756 YGL099W LSG1
SGTC_768 0384-0033 77.3 µM -0.29049709928829 0.385801028619001 no 2104 0.38571798479319 680 3965305 YMR134W ERG29
SGTC_1263 0774-1208 64.8 µM -0.290643926552112 0.385746463766612 no 2105 0.385661830526016 697 906585
SGTC_814 3342-0569 96 µM -0.290724220765107 0.385716625292605 no 2106 0.38563112291922 671 4346283
SGTC_1236 0330-0013 258 µM -0.2910983212307 0.385577613145247 no 2107 0.385488061911946 693 4617066
SGTC_268 camptothecin 39.6153 µM -0.291542982813608 0.385412400280141 no 2108 0.385318037656985 685 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1709 st033179 39.1045 µM -0.292604545207968 0.385018063628973 no 2109 0.384912219593012 672 573381
SGTC_3137 9097352 49.47 µM -0.29383216138732 0.384562191536969 no 2110 0.384443079039895 707 44120435
SGTC_2884 9058502 51.95 µM -0.294085126685054 0.384468273338013 no 2111 0.384346427905921 693 6471554
SGTC_1611 st001856 99.4 µM -0.294958387421251 0.384144110750648 no 2112 0.384012834106572 704 647478
SGTC_2378 9074213 121.43 µM -0.295463641799899 0.383956592567015 no 2113 0.383819861410444 649 657714
SGTC_1436 4092-1007 8.32 µM -0.297246675538071 0.38329506158285 no 2114 0.383139094688162 655 2881121
SGTC_2728 chlorpromazine 9.18 µM -0.298209089434457 0.38293813349946 no 2115 0.382771792434163 691 2726 A thorazine and dopamine antagonist.
SGTC_3027 9089541 49.47 µM -0.299252103877865 0.38255142550313 no 2116 0.382373848254369 685 9943819
SGTC_479 n-linoleoylglycine 10 µM -0.299667098895257 0.38239759450417 no 2117 0.382215548574005 700 6433346 An anti-infammatory.
SGTC_3023 9089636 49.47 µM -0.299939318932988 0.382296697634229 no 2118 0.382111721041273 665 17249241
SGTC_1526 st051518 75 µM -0.299941090261816 0.382296041127037 no 2119 0.382111045465924 674 673993
SGTC_1590 st077108 57.8 µM -0.300648051084832 0.382034047436204 no 2120 0.381841443064965 677 5489485
SGTC_989 1501-0895 10.3 µM -0.300680571468582 0.382021996956049 no 2121 0.381829042661151 688 2830112
SGTC_948 3448-0295 75.3 µM -0.30124500873158 0.381812862043572 no 2122 0.381613835437617 678 678569
SGTC_2734 clemastine 41.6 µM -0.30136978652865 0.381766634111547 no 2123 0.381566265408416 679 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1003 4049-0218 100 µM -0.303676156077648 0.38091246988697 no 2124 0.380687312664751 681 295161
SGTC_1703 st026983 48.3 µM -0.30404057063834 0.380777561869283 no 2125 0.380548491206863 690 1104023
SGTC_1182 1222-0449 220 µM -0.304300939228527 0.38068118104517 no 2126 0.380449314832743 671 658318
SGTC_1329 1447-1697 50.6 µM -0.305277195561834 0.380319865529062 no 2127 0.38007752139265 678 2840515
SGTC_1446 4239-0190 62 µM -0.307008647187974 0.379679306828076 no 2128 0.379418395181513 697 1340085
SGTC_485 niflumic acid 177 µM -0.308842113764059 0.379001367008914 no 2129 0.378720815966042 686 4488 A COX2 inhibitor.
SGTC_1122 capsaicin 818.572 nM -0.31004201646424 0.378557894077215 no 2130 0.378264502514991 719 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_851 0394-0702 453 µM -0.310481855127071 0.378395373792378 no 2131 0.378097277849709 676 762646
SGTC_2862 9027634 71.43 µM -0.312495452882238 0.377651624920319 no 2132 0.377332009120278 670 5012562
SGTC_595 3909-8003 73.7 µM -0.315609250854401 0.37650239611131 no 2133 0.376149557583525 712 699517
SGTC_1999 st074831 12.5 µM -0.315702619291543 0.376467952881214 no 2134 0.376114119200896 735 17112523
SGTC_2618 avocadyne 43.43 µM -0.316527334803284 0.376163761482704 no 2135 0.375801140357728 676 3015189
SGTC_2576 guaiol 23.12 µM -0.318023538678334 0.375612092067746 no 2136 0.37523354091647 676 227829
SGTC_1430 4049-0248 69.1 µM -0.318579662631805 0.375407106830572 no 2137 0.375022638676586 711 22774488
SGTC_1567 st069303 68.4 µM -0.319006391083685 0.375249840143437 no 2138 0.374860833203572 703 5581319
SGTC_2614 arthonioic acid 13.39 µM -0.319999976209693 0.374883744233195 no 2139 0.374484174293932 701 6710684
SGTC_1231 0242-0792 125 µM -0.320735867392144 0.374612670746513 no 2140 0.374205281933702 710 3707635
SGTC_1952 st077036 64.1 µM -0.320771394422054 0.374599585546892 no 2141 0.374191819355739 699 2937007
SGTC_80 0159-0065 512.242 µM -0.321237084148792 0.374428077585075 no 2142 0.374015365537732 672 1548079
SGTC_2437 5741531 144.16 µM -0.32145834691247 0.374346597857073 no 2143 0.373931536433003 682 2262990
SGTC_3199 9111318 49.47 µM -0.323005538247932 0.373777003639168 no 2144 0.373345523892489 693 8548020
SGTC_1721 st082152 9.2685 µM -0.323521859376191 0.37358698270299 no 2145 0.37315002774743 681 5296051
SGTC_1546 5-methoxyflavanone 78.7 µM -0.324186052085963 0.37334258599271 no 2146 0.372898590589073 680 147795
SGTC_779 1360-0071 233 µM -0.326150808159253 0.372619931850885 no 2147 0.372155128741577 691 7566
SGTC_1343 1487-0095 224 µM -0.32804774168202 0.371922648575269 no 2148 0.371437782741146 721 4560101 YGL055W OLE1
SGTC_1994 st072947 40.9 µM -0.328153453375825 0.371883802930163 no 2149 0.371397819822747 725 5286565 YDL195W SEC31
SGTC_1181 1222-0449 220 µM -0.328654069396495 0.371699860373324 no 2150 0.371208587340556 689 658318
SGTC_1960 st011366 51.8 µM -0.329268015580007 0.371474316626664 no 2151 0.370976558646718 671 3972846
SGTC_254 nsc-64875 3.808 µM -0.329619356704888 0.371345265232964 no 2152 0.370843797382644 702 56993
SGTC_883 0850-0245 24.6 µM -0.329751015005544 0.371296909440084 no 2153 0.370794051622329 684 6823229 YPR165W RHO1
SGTC_230 MPP+ 141.667 µM -0.330184127709979 0.371137849050916 no 2154 0.370630419599714 702 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_413 propylparaben 100 µM -0.331068257947499 0.370813221085519 no 2155 0.37029646369001 704 7175 A pharmaceutical preservative.
SGTC_2735 sertaconazole 140 nM -0.332379678290368 0.370331873484696 no 2156 0.369801290753843 679 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_76 0433-0009 400.328 µM -0.333205949981974 0.370028700457715 no 2157 0.369489413542541 751 2841569
SGTC_3028 9087778 49.47 µM -0.333724463581211 0.36983849028996 no 2158 0.369293743811911 658 17217395
SGTC_1820 st053765 18.6 µM -0.334337904903575 0.369613498205444 no 2159 0.369062295250398 698 3690829
SGTC_2951 9072950 58.06 µM -0.335667251761528 0.369126086465779 no 2160 0.368560901834586 696 16488155
SGTC_1065 prochlorperazine maleate 2.48 µM -0.336026784284044 0.368994298156247 no 2161 0.368425334358983 707 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_845 0330-0138 4.51 µM -0.336232814553045 0.36891878374794 no 2162 0.36834765473844 717 9039800
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.336296528724064 0.368895432194119 no 2163 0.368323633665008 694 2374 Ca(2+)-ATPase inhibitor.
SGTC_809 3998-0021 90 µM -0.336675707333274 0.36875647140119 no 2164 0.368180689033054 729 715485
SGTC_3161 9100388 49.47 µM -0.336804561760667 0.368709252934099 no 2165 0.368132117005309 687 25236368
SGTC_2062 5245942 200 µM -0.337009282312336 0.368634237542025 no 2166 0.368054951370359 677 1376160
SGTC_235 0330-0087 5 mM -0.33876522110577 0.367991017844629 no 2167 0.367393301596478 694 46494818 YHR062C RPP1
SGTC_1404 3909-7820 48.3 µM -0.339481596320602 0.367728707871902 no 2168 0.367123479408916 705 23741373
SGTC_2036 5160441 105 µM -0.339585277953058 0.367690748619485 no 2169 0.367084433232105 686 134534 YIL048W NEO1
SGTC_474 dl-dihydrosphingosine 5 µM -0.339889632151591 0.367579327884372 no 2170 0.366969822340021 682 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1564 D-Arginine 115 µM -0.340368576138164 0.367404014314544 no 2171 0.3667894900496 739 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_3097 9117246 49.47 µM -0.341099687856034 0.36713645008595 no 2172 0.366514268103288 666 16423892
SGTC_1053 3366-3204 134 µM -0.341501839554669 0.366989302522508 no 2173 0.366362910127395 692 3632071 YPR165W RHO1
SGTC_3116 9124943 49.47 µM -0.34316695834026 0.366380242648345 no 2174 0.365736430229774 665 41905195 YPL160W CDC60
SGTC_653 0203-0016 55.2 µM -0.344360438780388 0.365943903458084 no 2175 0.365287618391618 712 295302
SGTC_183 3914-0051 30.55 µM -0.344497474360102 0.365893814018767 no 2176 0.365236097550325 699 1596232
SGTC_2629 bisabolol 100 µM -0.345027822385582 0.365699982005977 no 2177 0.365036727178968 731 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_481 bay k-8644 50 µM -0.345501716911586 0.36552681166442 no 2178 0.364858609872928 747 2303 A calcium channel antagonist.
SGTC_1525 8-methoxypsoralen 92.5 µM -0.346659460108938 0.365103864949257 no 2179 0.36442358491658 750 4114 Related to psoralen; DNA damaging agent.
SGTC_670 4204-0025 119 µM -0.348599932068455 0.364395339904082 no 2180 0.363694839369981 705 719039
SGTC_264 promethazine 12.5 mM -0.348761927820361 0.364336211262826 no 2181 0.363634024010357 702 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_938 3126-1755 342 µM -0.348949465566808 0.364267763795462 no 2182 0.363563624137547 711 1777771
SGTC_1325 1431-0015 227 µM -0.349381844558621 0.364109970745975 no 2183 0.363401330766132 690 1103340
SGTC_3250 9135583 49.47 µM -0.351358158798882 0.363389025237971 no 2184 0.362659834112105 695 7699353
SGTC_33 0986-0033 35.816 µM -0.352825849543071 0.362853934772743 no 2185 0.362109501678305 690 2848082
SGTC_2158 5657123 3.6195 µM -0.353052212214917 0.36277143130391 no 2186 0.36202464896737 749 2858827
SGTC_350 k064-0020 19.8 µM -0.353701362577 0.362534867754535 no 2187 0.361781350671124 707 2790705
SGTC_1825 st052143 62.6 µM -0.354110178158283 0.362385913992321 no 2188 0.361628157303147 722 674173
SGTC_2343 7990716 14.84 µM -0.354261824242146 0.362330666367533 no 2189 0.36157133738053 677 6456862
SGTC_1453 4237-0541 195 µM -0.35471120801893 0.362166963938679 no 2190 0.361402976735735 697 739892
SGTC_2223 6903751 107.57 µM -0.355847956193089 0.361752979608348 no 2191 0.360977216391593 707 5598863
SGTC_1013 4112-3890 241 µM -0.356157824615485 0.361640158838525 no 2192 0.36086118738719 696 705171
SGTC_535 2293-4129 48.2 µM -0.357930916910785 0.360994820793959 no 2193 0.360197506546786 743 396118 YIL048W NEO1
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.359998791053375 0.36024269304077 no 2194 0.359424018820071 697 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_154 3389-1638 511.116 µM -0.362162986770374 0.359456110098397 no 2195 0.358615118519966 753 5238686
SGTC_2179 6298986 200 µM -0.362755649866628 0.359240808717637 no 2196 0.358393712285662 698 738374
SGTC_1574 spiramycin 23.7 µM -0.363016896541415 0.359145917772514 no 2197 0.358296131235558 689 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_3107 9121808 49.47 µM -0.364349280853222 0.358662099681289 no 2198 0.35779860213923 682 662681
SGTC_1403 3909-7815 62.9 µM -0.364716526013071 0.358528784700143 no 2199 0.357661510585421 696 6615483
SGTC_375 3970-0961 9.27 µM -0.36533038808328 0.358305982927142 no 2200 0.357432398657435 697 2898222
SGTC_3291 9121177 71.43 µM -0.367384859960522 0.357560661801308 no 2201 0.356665981617572 711 17015612
SGTC_2460 5552655 174.22 µM -0.367769381931871 0.357421225183927 no 2202 0.356522600546077 708 5401989
SGTC_2711 st079103 59.1 µM -0.367970528063351 0.35734829249547 no 2203 0.356447604980989 708 54693780
SGTC_1498 4478-3555 97.6 µM -0.367973367977372 0.35734726282087 no 2204 0.356446546183768 710 3437919
SGTC_1109 tnp00067 928.257 nM -0.368829328767968 0.357036962379671 no 2205 0.356127471168288 714 676295
SGTC_500 h-89 112 µM -0.369388472554173 0.35683431422209 no 2206 0.355919094483636 745 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1759 st043059 70 µM -0.369785815607067 0.356690331380135 no 2207 0.355771042396312 733 669426
SGTC_261 5-fluorouridine 15.376 µM -0.370048602208463 0.356595118175781 no 2208 0.355673138691184 699 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_659 k018-0002 107 µM -0.370819673793444 0.356315794050155 no 2209 0.355385923440709 714 6797879 YHR007C ERG11
SGTC_1360 1598-0022 39.8 µM -0.370896723584457 0.356287886652304 no 2210 0.355357227794414 733 761525
SGTC_431 k089-0097 107 µM -0.371150164079968 0.356196096055061 no 2211 0.355262844760613 726 5499420
SGTC_2346 9031566 143.75 µM -0.372151652334304 0.355833460504829 no 2212 0.354889970351201 716 4771086
SGTC_2917 7979103 53.79 µM -0.373257112395522 0.355433328537828 no 2213 0.354478546472971 724 2980565
SGTC_2595 hexamethylquercetagetin 100 µM -0.373557135233003 0.355324759833179 no 2214 0.354366914933674 750 386331
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.373972236394949 0.355174567310863 no 2215 0.354212486049357 713 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_874 0599-0792 117 µM -0.374514365066172 0.354978447383728 no 2216 0.354010835588602 753 765305
SGTC_1786 berberine 21.6 µM -0.376052891499743 0.354422080969686 no 2217 0.353438787615321 709 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1084 voriconazole 435 nM -0.376677637874613 0.354196246939228 no 2218 0.353206591622011 726 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2798 7813637 45.45 µM -0.378686800692234 0.353470320384003 no 2219 0.352460228083269 738 956368
SGTC_3014 9081533 49.47 µM -0.378813779853903 0.353424459668798 no 2220 0.352413076925364 744 21367265
SGTC_1504 k297-0033 30 µM -0.379286906375531 0.353253600602396 no 2221 0.352237410880919 685 4388117
SGTC_1623 st003709 20.3 µM -0.37982505366836 0.35305929668899 no 2222 0.352037641743549 672 16192618
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.381178293607332 0.352570864116675 no 2223 0.351535477326206 710 279621
SGTC_53 0973-0023 39.979 µM -0.38364326300528 0.351681793544286 no 2224 0.350621434961977 729 674768
SGTC_555 4296-0685 37 µM -0.383740764808869 0.351646643013941 no 2225 0.350585297770788 722 2908540 YHR072W ERG7
SGTC_490 phenamil 164 µM -0.384076469959586 0.351525627118769 no 2226 0.3504608853779 705 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_262 fenpropimorph 62.5 µM -0.384732298974681 0.351289255532192 no 2227 0.350217881307609 732 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_679 0422-0091 41.4 µM -0.385925903659611 0.350859208361108 no 2228 0.349775772814018 732 627384 YHR062C RPP1
SGTC_1429 4049-0205 9.46 µM -0.3881415027183 0.350061450614628 no 2229 0.348955660047868 711 22774478
SGTC_937 3122-0005 46.7 µM -0.389379185561406 0.349616093055938 no 2230 0.348497833523064 739 759535
SGTC_3303 9125618 40.5795 µM -0.390473809853849 0.349222384874969 no 2231 0.348093109035051 728 22695467
SGTC_103 0844-0104 51.839 µM -0.390733825539881 0.349128887751288 no 2232 0.347996996691432 720 5375804
SGTC_345 1362-0200 395 µM -0.391029105968626 0.349022721142919 no 2233 0.347887860909334 724 1419823
SGTC_519 k048-0011 62.8 µM -0.391246088167978 0.348944713804694 no 2234 0.347807672219954 706 6836379
SGTC_2253 7938677 135.83 µM -0.391292125260301 0.348928163816052 no 2235 0.347790659468708 705 2301972
SGTC_3168 9103419 49.47 µM -0.391966083258178 0.348685913896274 no 2236 0.34754163714039 713 16649256
SGTC_2045 5106652 78.05 µM -0.392035622267603 0.348660922050146 no 2237 0.347515946749822 715 673349
SGTC_2121 5257820 149.641 µM -0.392271999670084 0.348575974533523 no 2238 0.347428625062941 714 791256
SGTC_1741 st038134 10.228 µM -0.3929051806187 0.348348464188746 no 2239 0.347194757545043 734 1272587
SGTC_957 1187-1561 14.1 µM -0.394800170995074 0.34766789514144 no 2240 0.346495184359366 720 1538454
SGTC_2275 7947463 200 µM -0.395540131802427 0.347402277826832 no 2241 0.346222155105892 712 1225414
SGTC_3297 9117502 71.43 µM -0.396063065417982 0.347214610053745 no 2242 0.346029252287516 705 7453720
SGTC_184 1494-0393 24.714 µM -0.39626138566356 0.347143447680249 no 2243 0.345956105198134 720 3090647
SGTC_1378 2093-0007 380 nM -0.39645089486365 0.347075451970676 no 2244 0.345886213285518 751 3618014
SGTC_834 0312-0008 75.7 µM -0.396621480745277 0.347014250138899 no 2245 0.345823304875074 738 6385573 YIL048W NEO1
SGTC_1114 scopoletin 1.73284 µM -0.398061926368307 0.346497614510614 no 2246 0.345292269316429 728 5280460 A coumarin with genotoxic properties.
SGTC_526 4469-0568 170 µM -0.398443930819062 0.346360651204642 no 2247 0.345151490353177 700 2901964
SGTC_328 k915-0120 63.5 µM -0.401218162367149 0.345366586012071 no 2248 0.344129754953626 712 6624543
SGTC_2109 5483026 200 µM -0.402324675458772 0.344970396131255 no 2249 0.343722548514427 748 759335
SGTC_1496 4469-0713 57.4 µM -0.402462866598751 0.344920928361173 no 2250 0.343671705695501 746 746691
SGTC_1057 3448-5381 134 µM -0.402514691048896 0.344902377638237 no 2251 0.343652639347305 715 5497911
SGTC_199 4063-0024 41.6 µM -0.403854404546357 0.344422952534512 no 2252 0.343159893471327 726 306215
SGTC_1424 4048-1941 275 µM -0.404079940290724 0.344342267666042 no 2253 0.343076967741586 733 X1424
SGTC_245 methotrexate 289.6 µM -0.404292985056023 0.344266057921019 no 2254 0.342998641677187 715 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2922 7999257 32.47 µM -0.40692558849119 0.343324853484837 no 2255 0.342031320755781 714 2988377
SGTC_2403 6032726 181.2 µM -0.408112891174078 0.342900688116455 no 2256 0.341595398108673 718 2881040
SGTC_2881 9058953 51.95 µM -0.408433370254533 0.342786230465216 no 2257 0.341477769180717 691 17122249
SGTC_2090 5301565 104.445 µM -0.409107368984385 0.342545561967064 no 2258 0.341230434334834 721 2056344
SGTC_1295 1013-0063 9.78 µM -0.409160056451056 0.342526751250455 no 2259 0.341211102680517 724 6826038
SGTC_389 tpck 16.7 µM -0.41330566488783 0.34104789513302 no 2260 0.339691339979528 718 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2811 7967822 32.47 µM -0.41508631347059 0.340413434583766 no 2261 0.339039359157206 706 2232244
SGTC_1500 4488-1866 171 µM -0.415875119497865 0.340132520316188 no 2262 0.338750693311248 752 2900003
SGTC_287 k060-0039 29.6 µM -0.416678603614865 0.339846470004802 no 2263 0.338456753315758 721 5861974
SGTC_1034 k072-0165 12.7 µM -0.416964849013164 0.339744585356749 no 2264 0.338352059424902 753 5835461
SGTC_999 SEC7.066 22.7 µM -0.41708132382665 0.339703131288483 no 2265 0.338309462485937 706 740511 YDR170C SEC7
SGTC_3001 9076041 71.4286 µM -0.417551308639218 0.339535880640744 no 2266 0.338137601593309 718 16004211
SGTC_1625 st003711 30.1 µM -0.418411217203286 0.33922995200098 no 2267 0.337823243319129 722 24207034 YER133W GLC7
SGTC_492 tmb-8 126 µM -0.420986169354708 0.338314498692583 no 2268 0.336882590640231 725 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2315 7733312 200 µM -0.421588514869183 0.338100488954279 no 2269 0.336662695418723 712 726316
SGTC_2303 7774051 200 µM -0.422484558558485 0.337782226817169 no 2270 0.336335684620544 770 2953184
SGTC_3130 9127414 49.47 µM -0.426935420207736 0.336203065512519 no 2271 0.334713182933787 740 1494646
SGTC_964 1287-0107 19.4 µM -0.427128482765782 0.336134632220024 no 2272 0.334642874089895 723 51516812 YPR165W RHO1
SGTC_913 3487-1245 167 µM -0.427286679373138 0.336078561621263 no 2273 0.334585266926924 710 4016153
SGTC_182 3448-4371 550.524 µM -0.430094798026111 0.335083870791145 no 2274 0.333563341966858 688 3491403
SGTC_3094 9117742 49.47 µM -0.430397564817622 0.334976693727982 no 2275 0.333453233227233 764 17149698
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.430493049341539 0.334942895744184 no 2276 0.333418510860059 729 75037 A free radical scavenger.
SGTC_1649 st011737 51.3 µM -0.430906576526141 0.334796537875206 no 2277 0.333268150689723 727 1761035
SGTC_1317 1273-0028 910 nM -0.43148121840172 0.334593199050675 no 2278 0.333059253046079 727 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1755 st041960 45.185 µM -0.432087909106323 0.334378572284541 no 2279 0.332838761001956 761 2257073
SGTC_2832 7992762 51.95 µM -0.432359404417105 0.334282543901189 no 2280 0.332740109082721 701 2985177
SGTC_164 4100-3994 89.624 µM -0.43362190709352 0.333836136968492 no 2281 0.332281511894158 765 4615967
SGTC_587 k089-0003 57 µM -0.433744619774314 0.333792759651301 no 2282 0.332236950558296 719 9659696
SGTC_650 1328-0195 38 µM -0.434968933617474 0.33336010253491 no 2283 0.331792488652779 761 2780821
SGTC_2774 tamoxifen 10.92 µM -0.435365646349778 0.333219956754161 no 2284 0.331648521006042 733 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2023 5144124 124 µM -0.436539153706317 0.332805530917187 no 2285 0.331222799046124 742 2830192
SGTC_303 1348-1668 34.2 µM -0.437644939538827 0.332415207864148 no 2286 0.330821844440162 736 5380509
SGTC_2391 6285546 200 µM -0.438015307666594 0.332284514986473 no 2287 0.330687593423731 719 846083
SGTC_1651 st011928 86.1 µM -0.438288320590439 0.332188189177824 no 2288 0.33058864565797 728 720198
SGTC_1197 1601-0112 267 µM -0.438855214718003 0.331988210122766 no 2289 0.33038322468079 728 7350313
SGTC_352 k048-0007 5.11 µM -0.4410057045918 0.331230033128843 no 2290 0.329604433577222 759 6811911
SGTC_1602 st001878 87.6 µM -0.44339660272436 0.330387909332359 no 2291 0.32873944637902 779 595405 YLR310C CDC25
SGTC_776 4476-4378 112 µM -0.443645309197205 0.330300358975332 no 2292 0.328649521070294 774 2892008
SGTC_1988 st071872 53.4 µM -0.443782524664398 0.330252059973867 no 2293 0.328599912039496 727 16414116
SGTC_2197 6588183 93.1375 µM -0.446413470546835 0.329326530985368 no 2294 0.327649302087389 719 884136
SGTC_2412 st077135 33.4 µM -0.447234838188976 0.329037799382941 no 2295 0.327352754904378 775 13258915
SGTC_365 0121-0052 13.6 µM -0.44736313746823 0.328992708128909 no 2296 0.327306443468401 715 3101739
SGTC_966 1300-0360 30.2 µM -0.448082634373607 0.328739884414427 no 2297 0.32704678017055 750 70588
SGTC_2717 st081029 62.2815 µM -0.448659336160693 0.328537293984533 no 2298 0.326838711434906 760 5292846
SGTC_1169 aniline yellow 25.8 µM -0.450632731813956 0.327844438435931 no 2299 0.326127135896899 742 6051 A DNA damaging agent.
SGTC_2350 9023895 38.85 µM -0.45563012236728 0.326092516751977 no 2300 0.324327989224447 720 2997209
SGTC_1349 flufenamic acid 69 µM -0.455889564267977 0.326001669202912 no 2301 0.324234697096074 737 3371 A non-steroidal anti-inflammatory.
SGTC_2814 7977482 42.97 µM -0.456733207198166 0.32570632614481 no 2302 0.323931409735891 749 6456762
SGTC_1046 2001-0062 216 µM -0.457252713631776 0.32552451139459 no 2303 0.323744706689087 745 739778
SGTC_1414 3917-0015 5.4 µM -0.459388158273886 0.324777593509742 no 2304 0.322977725195353 751 6618702
SGTC_1793 st048256 72.231 µM -0.459986257695302 0.324568521384043 no 2305 0.322763042245669 760 672022
SGTC_1422 4031-0024 15.5 µM -0.462665756744828 0.323632552744828 no 2306 0.321801983513241 760 782427
SGTC_713 1488-1073 324 µM -0.462954515145046 0.323531753745717 no 2307 0.321698485211303 759 3312542
SGTC_1732 st034308 51.822 µM -0.464410438125032 0.323023721444446 no 2308 0.321176856524456 710 830119
SGTC_2910 7948405 25.97 µM -0.465620976092375 0.322601565404143 no 2309 0.320743412893267 750 2971328
SGTC_1438 4092-1045 4 µM -0.466228885208345 0.322389652860804 no 2310 0.320525837848437 743 1351342
SGTC_2904 7225135 42.03 µM -0.466420153505063 0.322322990101945 no 2311 0.32045739429801 775 4446116
SGTC_452 diindolylmethane 8 µM -0.467009985358602 0.32211745193158 no 2312 0.320246367004187 744 3071 Inhibits expression of several cancer promoting factors.
SGTC_1261 0712-0010 12.7 µM -0.468957520377525 0.321439182729095 no 2313 0.319550000083753 755 2840123
SGTC_1675 st018485 24.5 µM -0.470088852749642 0.321045445942444 no 2314 0.319145768992953 755 3323024
SGTC_995 3931-2021 34.6 µM -0.47047282437435 0.320911858268196 no 2315 0.319008622714203 753 730143
SGTC_3351 9150312 21.596 µM -0.471476451538279 0.320562795580033 no 2316 0.318650266049722 754 4904905
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.471488216927728 0.320558704504163 no 2317 0.318646066086389 729 6708630 An antioxidant.
SGTC_3065 9113888 49.47 µM -0.476449119976072 0.318835640861357 no 2318 0.316877223701574 771 16648368
SGTC_2056 5235370 200 µM -0.477628361414776 0.31842663014362 no 2319 0.316457370510897 747 5511916
SGTC_2472 5377652 49.4 µM -0.479573167811521 0.317752572563744 no 2320 0.315765464785401 778 1610903
SGTC_12 0849-0099 9.267 µM -0.481994704991684 0.316914126815141 no 2321 0.314904853874901 773 6071388
SGTC_1245 0418-0076 17.2 µM -0.484180791975013 0.316158011118631 no 2322 0.314128783747229 775 6790114
SGTC_1144 3486-0183 12.5 µM -0.485565864801651 0.315679344549904 no 2323 0.313637501731508 790 6744069
SGTC_865 0488-0499 301 µM -0.485834416202864 0.315586571758493 no 2324 0.313542285399166 766 9634651
SGTC_113 0099-0221 2.5 µM -0.487685668742076 0.31494736120389 no 2325 0.312886252180705 745 89219
SGTC_2244 6635614 200 µM -0.490472198017055 0.313986257879056 no 2326 0.311899899250371 743 836499
SGTC_528 3492-0019 172 µM -0.49223509491799 0.313378866608042 no 2327 0.311276578729029 753 2869262
SGTC_1680 diphenhydramine 100 µM -0.492680626172567 0.313225442571398 no 2328 0.31111913446933 765 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1519 esterone 74 µM -0.497002853845426 0.311738712715601 no 2329 0.30959351942039 744 698 A steroid.
SGTC_418 lividomycin a 100 µM -0.498554843879471 0.31120561607296 no 2330 0.309046511774889 749 72394 An antibiotic.
SGTC_2715 st079500 56.4 µM -0.498972447237532 0.31106224005695 no 2331 0.308899397310639 759 28246688
SGTC_3184 9108758 49.47 µM -0.499397180607979 0.310916445496568 no 2332 0.308749802506938 763 902885
SGTC_2616 abietic acid 100 µM -0.500572385976581 0.310513197591423 no 2333 0.30833605031477 779 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_276 colchicine 750 µM -0.500637138884144 0.310490985555164 no 2334 0.3083132599578 791 2833 A microtubule depolymerizer.
SGTC_3104 9120930 49.47 µM -0.501213828836869 0.31029319545731 no 2335 0.308110321440103 776 17014836
SGTC_2657 nystatin 74.44 µM -0.504452322315977 0.309183494228383 no 2336 0.306971779054201 759 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2114 5491910 81.25 µM -0.505129175084111 0.30895178338238 no 2337 0.3067340555206 769 2849228
SGTC_2132 5317594 122.667 µM -0.506876694052755 0.308353896904566 no 2338 0.306120669650513 775 794577
SGTC_1974 st069448 26.9 µM -0.507394197622324 0.30817693851151 no 2339 0.305939128073644 753 6323587 YNR016C ACC1
SGTC_687 k029-0044 34.9 µM -0.507472206330243 0.308150267593403 no 2340 0.305911766552193 769 5829338
SGTC_1398 3558-0053 112 µM -0.507789615147725 0.308041757020499 no 2341 0.30580044671424 742 4532369
SGTC_3251 9135047 49.47 µM -0.508369035190731 0.307843717579458 no 2342 0.30559728204403 744 17682963
SGTC_3255 9139072 49.47 µM -0.512427516467597 0.306458144321022 no 2343 0.304175918585227 752 17646060
SGTC_1904 st060225 78 µM -0.513782841344711 0.305996048103862 no 2344 0.303701912853259 736 66595
SGTC_2655 perillic acid 100 µM -0.514481362584216 0.305758008672706 no 2345 0.30345774372635 764 5702197 An apoptosis inducer.
SGTC_2300 7976697 71.57 µM -0.514876145174529 0.305623512433801 no 2346 0.303319785689065 745 2236109
SGTC_1330 1469-0054 61.8 µM -0.515957711215927 0.305255174204085 no 2347 0.302941972662614 766 7102664
SGTC_2326 6164455 177.58 µM -0.517866252705866 0.304605682111913 no 2348 0.302275794618357 758 2888790
SGTC_1971 st069429 63.5 µM -0.518519444803442 0.304383536832292 no 2349 0.302047948426875 776 1246522 YGL099W LSG1
SGTC_2681 menadione 3.18 µM -0.518749258534246 0.304305396220339 no 2350 0.301967803243304 768 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2280 7785178 200 µM -0.519454713437133 0.304065585265491 no 2351 0.301721842765727 737 2954328
SGTC_403 arphamenine a 50 µM -0.520755964353844 0.303623461719967 no 2352 0.301268391428921 779 5487158 An arginine aminopeptidase inhibitor.
SGTC_2019 4016004 108 µM -0.52140678560013 0.303402441148073 no 2353 0.301041712733644 775 45595336
SGTC_325 2810-4341 181 µM -0.521853940326516 0.303250627927005 no 2354 0.300886014922324 746 774970
SGTC_2301 7769476 200 µM -0.522180709409994 0.303139708241449 no 2355 0.300772257970086 768 977820
SGTC_2057 5236571 38.335 µM -0.522222367228464 0.303125569064279 no 2356 0.300757757177446 760 54684039 YBR257W POP4
SGTC_3141 9094609 49.47 µM -0.522749421111314 0.302946705959341 no 2357 0.300574320689767 773 25236309 YDL196W YDL196W
SGTC_3296 9122258 64.045 µM -0.522859306641318 0.302909420719875 no 2358 0.300536082358355 775 4730474
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.523964339093452 0.302534586610589 no 2359 0.300151671684738 771 616764
SGTC_3049 9092223 49.47 µM -0.524451040425353 0.302369560372331 no 2360 0.299982432118633 780 8623917
SGTC_657 3534-0529 86.7 µM -0.524977704843332 0.302191029316059 no 2361 0.299799344937381 782 1049549
SGTC_2659 sanguinarine 24.21 µM -0.525521529880595 0.302006730742651 no 2362 0.299610345233168 790 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1148 3909-7663 27.7 µM -0.525656137638329 0.301961120892582 no 2363 0.299563572298986 798 4084526
SGTC_1188 1403-0014 4.57 µM -0.526513117748647 0.30167081843089 no 2364 0.299265870105308 760 9614867
SGTC_1087 pterostilbene 9.05 µM -0.52687492968234 0.301548292140138 no 2365 0.299140222309416 778 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2004 4023728 41.89 µM -0.528392190531977 0.301034721282863 no 2366 0.298613578347441 778 360084 YDR527W RBA50
SGTC_3333 9141820 12.094 µM -0.529152018351981 0.300777678800128 no 2367 0.298349999294214 755 1939433
SGTC_2338 7999974 200 µM -0.52963616834084 0.300613947158838 no 2368 0.298182106245853 791 315925
SGTC_1068 loratadine 26.9 µM -0.530107258087163 0.300454670914173 no 2369 0.298018783535121 779 3957 A H1 histamine antagonist.
SGTC_1460 k062-0059 9.15 µM -0.531317980774728 0.300045498503963 no 2370 0.297599223677617 735 1373085
SGTC_1966 st070145 16.1 µM -0.531735254887143 0.299904536162174 no 2371 0.297454685375552 764 3748532
SGTC_1042 0350-0096 82 µM -0.532749475799143 0.299562040004131 no 2372 0.29710350622605 756 3122515
SGTC_2076 5212012 200 µM -0.533258089387678 0.299390351088817 no 2373 0.296927467586629 770 604802
SGTC_1127 asiatic acid 681.4 nM -0.536293575017503 0.298366613919173 no 2374 0.295877835174853 775 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_3145 9085516 49.47 µM -0.537348553668263 0.298011189027062 no 2375 0.295513436395483 769 25236195
SGTC_972 1319-0219 195 µM -0.538686822022959 0.297560600999073 no 2376 0.295051484075534 780 23903702
SGTC_2255 7941087 197.44 µM -0.542531199827828 0.296267952124308 no 2377 0.29372631010385 766 935561
SGTC_432 NS 1619 61.3 µM -0.543057601343622 0.296091153433553 no 2378 0.293545071786157 755 4552 A K+/calcium channel activator.
SGTC_1079 idarubicin 2.36 µM -0.546416174573432 0.294964275294139 no 2379 0.292389947150839 800 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_258 haloperidol 50.781 µM -0.547362405963426 0.294647150174485 no 2380 0.292064888825052 788 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_155 k072-0202 43.6 µM -0.549839791573181 0.293817611555056 no 2381 0.291214631704301 797 5857737
SGTC_1964 st076914 61 µM -0.551295094976314 0.293330815719772 no 2382 0.290715700193784 800 24208661
SGTC_672 1441-0018 53.7 µM -0.551337381255151 0.293316676640671 no 2383 0.290701208881376 748 251141
SGTC_2549 cedrol 20.94 µM -0.551796168393291 0.293163294288498 no 2384 0.290544006369564 787 6708665 A sedative which affects the nervous system.
SGTC_2234 tolnaftate 200 µM -0.552367758306379 0.2929722516058 no 2385 0.29034820788129 784 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1241 0364-0022 50.8 µM -0.554793569422822 0.292162115492513 no 2386 0.28951793306538 788 4563895
SGTC_1082 camptothecin 424.86 nM -0.554905948066725 0.292124610231424 no 2387 0.289479496614247 798 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1529 apigenin 74 µM -0.555403427271364 0.291958608386627 no 2388 0.289309374439817 811 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1035 k081-0041 55.2 µM -0.555806988182874 0.291823978039427 no 2389 0.289171403880669 789 731709
SGTC_2779 methotrexate 400 µM -0.555950301973822 0.291776174657015 no 2390 0.289122414796527 771 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2102 5377816 72.7585 µM -0.556885635724367 0.291464276769167 no 2391 0.288802784699095 792 1379702
SGTC_828 2074-0507 139 µM -0.557172938653298 0.291368503506629 no 2392 0.288704638537576 779 X828
SGTC_2977 9011197 71.43 µM -0.560379093707821 0.290300720111145 no 2393 0.287610444262071 802 2704722
SGTC_29 0299-0004 12.984 µM -0.560433017789121 0.29028277682383 no 2394 0.287592057864137 783 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2724 maprotiline 69.64 µM -0.561210599653604 0.290024093518212 no 2395 0.287326988954272 782 4011 A tricyclic antidepressant.
SGTC_2852 9023854 51.95 µM -0.563123634697847 0.289388131904214 no 2396 0.286675349309576 812 19798528
SGTC_959 1222-0044 107 µM -0.563840192870675 0.289150090988139 no 2397 0.286431447688213 778 6083612
SGTC_3092 9117248 49.47 µM -0.56481374336873 0.288826824714878 no 2398 0.286100229057675 791 17141857
SGTC_2124 5246320 200 µM -0.565929076244174 0.288456688999041 no 2399 0.285720997420467 772 579342
SGTC_1130 3454-2858 15.9 µM -0.568727378600539 0.287529026414406 no 2400 0.284770582357358 820 715628 YIL048W NEO1
SGTC_2251 lansoprazole 556 µM -0.569724000841094 0.287198978090864 no 2401 0.284432454433129 791 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1100 amiodarone 5.07 µM -0.569876630598546 0.287148448002306 no 2402 0.284380688080811 761 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2661 dactinomycin 12.96 µM -0.574215511406573 0.285713767972567 no 2403 0.282910987017354 789 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_3082 9117008 49.47 µM -0.575327163507597 0.285346742257938 no 2404 0.282535026942368 786 41448529
SGTC_2423 st077119 87.2 µM -0.575683681925628 0.28522908086279 no 2405 0.282414503518925 765 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2438 5259590 200 µM -0.576947029541829 0.284812325801803 no 2406 0.281987619634508 788 1201127
SGTC_1288 0973-0013 65.5 µM -0.577653341138932 0.284579453344285 no 2407 0.281749093186634 786 4315430
SGTC_1698 5-fluorocytosine 1.055 µM -0.578157414227876 0.284413314978716 no 2408 0.28157892361463 791 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_963 1269-2853 151 µM -0.579832442360604 0.283861572524098 no 2409 0.281013808719117 757 3668223
SGTC_310 1273-0058 1.06 µM -0.579994154937805 0.283808332672942 no 2410 0.280959279739648 771 2734232
SGTC_1986 st071812 45 µM -0.58031108983542 0.283704003594846 no 2411 0.280852425109511 802 11838594
SGTC_3177 9107506 49.47 µM -0.580466421820933 0.283652877900008 no 2412 0.280800062091415 792 8897194
SGTC_636 0kpi-0074 126 µM -0.580531575346862 0.28363143469764 no 2413 0.280778099989113 793 616434
SGTC_3329 9141233 27.5565 µM -0.581242869982999 0.28339738531329 no 2414 0.280538389185725 804 4909101 YNL103W MET4
SGTC_2154 5570129 200 µM -0.583733023753792 0.282578737914254 no 2415 0.279699972735075 818 673366
SGTC_74 000s-0487 160.283 µM -0.584023383335851 0.282483355167612 no 2416 0.279602290014706 768 677548
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.584665355495885 0.282272523116983 no 2417 0.279386376653267 768 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2671 danthron 100 µM -0.584861393162246 0.28220815687926 no 2418 0.279320459797956 787 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_290 2043-6722 48.1 µM -0.585267889376963 0.282074712023657 no 2419 0.279183801209272 785 773758 YLR208W SEC13
SGTC_1334 1486-0610 236 µM -0.586465876804837 0.281681612708878 no 2420 0.278781242998464 777 3742339
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.587167253719752 0.281451590387153 no 2421 0.27854569138921 797 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2896 9052656 71.43 µM -0.588760091453297 0.28092954305295 no 2422 0.278011110422597 797 6469436
SGTC_1554 st069299 38.7 µM -0.589465262609334 0.280698575081047 no 2423 0.277774604055912 769 24207999
SGTC_2384 9036245 200 µM -0.590700296346784 0.280294280206439 no 2424 0.277360624683077 786 6462766
SGTC_1797 st048695 56.8 µM -0.591067522177973 0.280174121294894 no 2425 0.277237589965943 827 592262 YIL048W NEO1
SGTC_146 3448-8650 53.125 µM -0.591216851157009 0.280125266926783 no 2426 0.277187566675349 821 2891488 YIL048W NEO1
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.591431885634184 0.280054923645568 no 2427 0.277115540645062 802 165521
SGTC_2177 5811945 192 µM -0.593825026676959 0.279272644376262 no 2428 0.276314574168386 792 5343475
SGTC_1512 0259-0544 12.2 µM -0.594160396224912 0.27916310236089 no 2429 0.27620241928031 781 18476
SGTC_815 1582-0027 36.9 µM -0.594309051215001 0.279114553748258 no 2430 0.276152712958171 805 3128206
SGTC_3064 1327-0027 10 µM -0.596249160787404 0.278481318129012 no 2431 0.275504394197772 774 16000455 YPR107C YTH1
SGTC_1902 st060212 70.5 µM -0.596461255480427 0.278412134649827 no 2432 0.275433564771575 773 688944
SGTC_1953 st076800 12.1 µM -0.601410292190155 0.276800183313013 no 2433 0.27378337262219 801 297591
SGTC_1873 rapamycin 2 nM -0.602766291130622 0.276359319969724 no 2434 0.273332087224768 777 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_3185 9108267 49.47 µM -0.602899759618743 0.276315945226062 no 2435 0.27328768795405 799 4910486
SGTC_3099 9120367 49.47 µM -0.603705796313165 0.276054069499869 no 2436 0.27301962989463 813 24824940
SGTC_2627 acetyl isogambogic acid 100 µM -0.605095232369269 0.275602937654223 no 2437 0.272557860946533 807 6857789 A caspase activator and apoptosis inducer.
SGTC_2624 nerol 100 µM -0.60530265506111 0.275535621310875 no 2438 0.272488958803178 826 637566 A natural product oil.
SGTC_3352 9151559 45.5865 µM -0.605839352104102 0.275361480789012 no 2439 0.272310717706674 782 17159339
SGTC_695 3505-6186 243 µM -0.606135431336458 0.27526543601074 no 2440 0.272212412381299 812 1819379
SGTC_721 1187-1332 279 µM -0.607957507349309 0.274674738262106 no 2441 0.271607828472193 810 25730
SGTC_1857 st056007 79.3 µM -0.609129194431003 0.274295220244782 no 2442 0.271219403952213 785 619834
SGTC_2936 9038235 15.59 µM -0.611530901201626 0.273518100047695 no 2443 0.270424083712846 795 4749415
SGTC_3245 9134821 49.47 µM -0.612272858175007 0.273278245569803 no 2444 0.27017862205593 824 17014901
SGTC_3195 9113082 49.47 µM -0.613060352768399 0.273023784045592 no 2445 0.269918217144549 803 17018038
SGTC_3103 9120822 49.47 µM -0.613282146625911 0.272952137453392 no 2446 0.26984489810265 821 17141819
SGTC_1558 st069300 45.6 µM -0.614110846980168 0.272684522942904 no 2447 0.26957104046816 802 24208000
SGTC_2084 5306078 60.6385 µM -0.614854398153475 0.272444516773271 no 2448 0.269325440369778 820 679340
SGTC_2518 prenyletin 46.28 µM -0.615296717579993 0.272301793073228 no 2449 0.269179392448427 782 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1205 4161-2785 76 µM -0.617217433173682 0.271682464865934 no 2450 0.268545659226288 809 3498106
SGTC_1054 3429-0080 167 µM -0.617254880201765 0.27167039717164 no 2451 0.26853331117105 815 1162877
SGTC_3180 9109287 49.47 µM -0.618031119732216 0.271420306022863 no 2452 0.268277412599937 794 18891271
SGTC_569 4130-2812 160 µM -0.618985567811352 0.271112956424057 no 2453 0.267962933253301 815 743552
SGTC_1344 1488-0097 29.1 µM -0.619292263166066 0.271014231814448 no 2454 0.267861920185664 827 747966
SGTC_135 0933-0004 26.348 µM -0.619614410740022 0.270910552482252 no 2455 0.267755838439134 799 21230617 YGL099W LSG1
SGTC_741 4582-0002 126 µM -0.620681801088852 0.270567167198672 no 2456 0.267404502933635 812 2912688
SGTC_2085 5307070 144.047 µM -0.620779792157593 0.270535653838446 no 2457 0.267372260466304 821 2840351
SGTC_1995 st072814 61.1 µM -0.621513454387514 0.270299770588361 no 2458 0.267130922419448 787 5769371
SGTC_761 k216-0224 480 µM -0.623597481083339 0.269630286581156 no 2459 0.266445982645295 844 1340404
SGTC_417 st075190 100 µM -0.625357357197036 0.269065582150789 no 2460 0.265868271462424 816 222757
SGTC_2361 9034121 116 µM -0.626435471640263 0.268719933036855 no 2461 0.265514674696377 832 6496917
SGTC_2815 7968870 71.43 µM -0.628869754274986 0.267940310689742 no 2462 0.264717164354751 803 2977326 YHR190W ERG9
SGTC_694 1315-0438 43.2 µM -0.629611672519309 0.267702924850196 no 2463 0.264474342377856 800 6793154
SGTC_100 0086-0128 49.5915 µM -0.630138090160283 0.267534555375871 no 2464 0.264302120235524 836 93297
SGTC_773 4358-1457 44.6 µM -0.630199915790433 0.267514784563949 no 2465 0.264281897186669 841 1186886
SGTC_3175 9106517 49.47 µM -0.630433494903555 0.267440096484676 no 2466 0.264205501004382 831 41468073
SGTC_2770 toltrazuril 17.5 µM -0.631158819662585 0.267208237352153 no 2467 0.263968342418614 797 68591 Kills coccidiodes.
SGTC_405 ebelactone b 50 µM -0.631238550485008 0.267182756587776 no 2468 0.263942279545432 809 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1722 st034304 3.6505 µM -0.63180519573665 0.267001700678594 no 2469 0.263757089055602 804 4036148 YLR033W RSC58
SGTC_279 1273-0055 2.93 µM -0.632455613118363 0.266793954097168 no 2470 0.263544601948377 829 2847562
SGTC_1385 3091-4834 14.1 µM -0.632881453333298 0.266657982853355 no 2471 0.263405530068708 792 4072814
SGTC_1828 st055811 49 µM -0.633601596074089 0.266428120238954 no 2472 0.263170429474501 818 5877589
SGTC_1050 3232-1156 69.3 µM -0.637955862246817 0.265040419285749 no 2473 0.261751206112579 821 700529
SGTC_3270 9137563 49.47 µM -0.638326726394452 0.264922395114201 no 2474 0.261630508889105 794 17015724
SGTC_886 0866-0150 153 µM -0.639761383974682 0.264466079926122 no 2475 0.261163870680509 800 271463
SGTC_3147 9097027 49.47 µM -0.639969744567315 0.264399840874285 no 2476 0.261096134687529 834 25236841
SGTC_897 1000-0139 31.4 µM -0.641238113013549 0.263996801369784 no 2477 0.260683995388762 807 6151020
SGTC_950 1165-0508 94.1 µM -0.641444535453173 0.263931237764978 no 2478 0.260616952880796 808 6148369
SGTC_1845 st056753 3.01 µM -0.641564600731267 0.263893106618339 no 2479 0.260577961797365 807 5375839
SGTC_2727 riluzole 51.77 µM -0.643772071665922 0.263192543828911 no 2480 0.25986162329909 824 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_477 mead ethanolamide 10 µM -0.643772971538164 0.263192258439379 no 2481 0.259861331492058 774 16061185
SGTC_745 0469-0705 296 µM -0.64381012230102 0.263180476417269 no 2482 0.259849284536295 829 3486736
SGTC_2958 9077254 16.72 µM -0.643990457599917 0.263123288567598 no 2483 0.259790810924968 799 16457351
SGTC_905 2-aminofluorene 215 µM -0.645082923816612 0.26277698196022 no 2484 0.259436724625068 816 1539 An established DNA mutagen. YPR165W RHO1
SGTC_876 0720-0963 56.8 µM -0.645223190259583 0.262732535056733 no 2485 0.259391280024655 827 765861
SGTC_1826 st055655 41.6 µM -0.645282996967782 0.262713584986513 no 2486 0.259371904638198 819 676168
SGTC_2171 5739187 198.077 µM -0.645817126431112 0.262544374268658 no 2487 0.259198897601357 796 2262761
SGTC_805 3852-0218 479 µM -0.646412518176587 0.262355821599835 no 2488 0.259006117751979 802 6615355
SGTC_1008 4106-0037 6 µM -0.64659544135164 0.26229790618541 no 2489 0.258946904579554 835 2905394
SGTC_1733 st037357 54.9 µM -0.647993803772665 0.261855386309795 no 2490 0.258494478953662 826 1272339 YGL099W LSG1
SGTC_1135 dihydrocapsaicin 536.708 nM -0.648158003114962 0.2618034496097 no 2491 0.258441380836497 823 107982 A Capsaicinoid.
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.651245673173913 0.260827796016369 no 2492 0.257443955737486 804 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_497 capsazepine 133 µM -0.651454513946495 0.260761873322291 no 2493 0.257376565167193 808 2733484 A calcium channel blocker.
SGTC_998 3996-0085 177 µM -0.652149982219577 0.260542403581551 no 2494 0.257152211481007 821 715391
SGTC_190 3970-0790 3.722 µM -0.654614147424861 0.259765550238784 no 2495 0.256358106531693 814 2832352
SGTC_2838 9002687 71.43 µM -0.656067520225875 0.259307920611646 no 2496 0.255890340697548 820 6457060
SGTC_416 estradiol valerate 100 µM -0.656121463527162 0.259290943278286 no 2497 0.255872987704623 823 13791 A steroid.
SGTC_2543 pimpinellin 60.67 µM -0.656264352593651 0.25924597521905 no 2498 0.255827024762288 813 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_3274 9138298 49.47 µM -0.656572646474499 0.259148966988834 no 2499 0.255727870947621 825 17015756
SGTC_627 1391-0720 175 µM -0.656878380608342 0.259052782748714 no 2500 0.255629560220736 843 997839
SGTC_854 0422-0053 192 µM -0.659398588350404 0.258260626927067 no 2501 0.254819924192487 827 3596728
SGTC_46 0329-0187a 2.197 µM -0.661032591539137 0.257747696089397 no 2502 0.254295706354993 821 46494817
SGTC_831 k061-1017 217 µM -0.662440075862154 0.257306296212645 no 2503 0.253844613522875 830 1240153
SGTC_2227 7312221 64.1025 µM -0.663746539818068 0.256896929112138 no 2504 0.253426273499125 838 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_292 k038-0015 474 µM -0.663938843781757 0.25683670126103 no 2505 0.253364726864712 830 46368540
SGTC_1513 0337-0559 19 µM -0.66464372550405 0.256616001572837 no 2506 0.253139197579426 820 775073
SGTC_736 0958-0254 92.6 µM -0.665110946107108 0.256469768439602 no 2507 0.252989766981752 836 6812352
SGTC_1628 st004252 77.7 µM -0.668759952977954 0.255329178678328 no 2508 0.251824308271491 815 692968
SGTC_1666 st014829 29 µM -0.669537329417827 0.255086532979296 no 2509 0.251576388246935 820 3858230
SGTC_2891 9063876 19.48 µM -0.669865256973598 0.254984211788892 no 2510 0.251471844640512 814 6472478
SGTC_2986 9022445 71.43 µM -0.670652995346987 0.254738506476587 no 2511 0.251220806765121 832 6459286
SGTC_2456 5770359 74.46 µM -0.672813135295578 0.254065368790304 no 2512 0.25053309005529 844 3118787
SGTC_2534 helenine 20.12 µM -0.673331827366903 0.253903874239707 no 2513 0.250368104393204 812 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2664 lyso-paf C-16 73.48 µM -0.673340344674094 0.253901222829496 no 2514 0.2503653956874 832 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2279 7948423 32.93 µM -0.674572882580411 0.253517691015995 no 2515 0.249973583216486 795 1247112
SGTC_3046 9092212 49.47 µM -0.674888952212964 0.253419387921352 no 2516 0.249873160031719 838 25236637
SGTC_2368 9071271 200 µM -0.676470191684015 0.252927896199948 no 2517 0.249371082646299 835 27209959
SGTC_1780 st038448 24.544 µM -0.677116073754339 0.252727283098323 no 2518 0.249166155625723 837 728868 YDL195W SEC31
SGTC_1373 2887-0003 58.5 µM -0.678067068521179 0.252432053568626 no 2519 0.248864584818776 837 776948
SGTC_1761 st044296 37 µM -0.678385215547627 0.252333327687448 no 2520 0.248763740317624 837 1826700
SGTC_1106 tegaserod maleate 11.7 µM -0.67860826600953 0.252264123862416 no 2521 0.248693051981343 831 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1028 k015-0029 4.8 µM -0.67873498304523 0.252224812985764 no 2522 0.24865289804748 837 4588309
SGTC_2622 2-methoxyxanthone 59.94 µM -0.678920922458158 0.252167135656101 no 2523 0.248593984053278 816 71034 A hepatoprotective.
SGTC_2942 9052777 62.25 µM -0.680390445158486 0.251711543068569 no 2524 0.248128634696915 858 6469503
SGTC_1077 5-fluorocytosine 377 nM -0.680919171799732 0.251547729618781 no 2525 0.247961318146701 847 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1221 2958-7315 257 µM -0.681100366017466 0.251491603835899 no 2526 0.247903992747329 829 4562705
SGTC_2608 thymoquinone 42.66 µM -0.68154977910352 0.251352424530786 no 2527 0.247761840021546 826 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2442 5158906 48.48 µM -0.682910103137885 0.250931392339906 no 2528 0.247331824721219 820 1893835
SGTC_252 miconazole 1.30953 nM -0.682970024817803 0.250912854642585 no 2529 0.247312891913487 824 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2823 7987624 58.44 µM -0.683809963330571 0.250653082997003 no 2530 0.247047587154478 851 2239440
SGTC_228 caffeine 993.056 µM -0.68385036499324 0.250640591380792 no 2531 0.247034829638845 803 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2138 5575593 77.673 µM -0.684282553306276 0.250506985569342 no 2532 0.246898380845289 832 762213
SGTC_836 0330-0104 1.35 µM -0.6845644573163 0.250419858679984 no 2533 0.246809400961377 821 46494820
SGTC_1908 st060353 56.5 µM -0.684888932980149 0.250319594233859 no 2534 0.246707005060794 852 4227716
SGTC_1337 1486-1011 40.3 µM -0.685334914627782 0.25018181862725 no 2535 0.246566302228957 824 X1337
SGTC_1506 4226-2149 212 µM -0.68550421069405 0.250129529097484 no 2536 0.246512902240419 841 991114
SGTC_9 0092-0002 10.449 µM -0.686345194007981 0.249869865229446 no 2537 0.246247728052866 837 759368
SGTC_2112 5488546 200 µM -0.686539275694544 0.249809960466649 no 2538 0.246186553020997 845 600757
SGTC_944 3370-0224 231 µM -0.686634291170604 0.249780636010388 no 2539 0.24615660687769 815 4580514
SGTC_2708 st078559 56 µM -0.686776336317775 0.249736800279767 no 2540 0.246111841979163 806 17250902
SGTC_1345 1488-0192 31.4 µM -0.688976715945119 0.249058275966135 no 2541 0.245418960135244 832 658348
SGTC_2989 9073649 71.4286 µM -0.689422780652756 0.248920844026961 no 2542 0.245278625848092 845 21367202
SGTC_2329 6138490 200 µM -0.689884114739388 0.248778750081659 no 2543 0.245133533125592 844 720019
SGTC_2505 galangin 7.89 µM -0.690080201632033 0.248718367105807 no 2544 0.245071876440036 844 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_985 1493-0307 8.71 µM -0.691633477969315 0.248240327268243 no 2545 0.244583766058114 841 3278274
SGTC_1774 st048371 48.465 µM -0.691762653979525 0.248200593845499 no 2546 0.244543196651381 843 4242727
SGTC_95 0471-0001 561.058 µM -0.692726975812496 0.247904083990556 no 2547 0.244240453398746 822 4015405
SGTC_847 0342-0274 5.54 µM -0.693042130509443 0.247807221172144 no 2548 0.244141556232813 838 18097
SGTC_2129 girgensonine 121.053 µM -0.693075025613224 0.247797112024353 no 2549 0.244131234824699 834 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2203 7227154 166.4 µM -0.69360058997525 0.247635628252736 no 2550 0.243966361827517 824 896304
SGTC_983 1491-0821 12.2 µM -0.694673901838428 0.247306019449963 no 2551 0.243629843527752 819 46495113
SGTC_2938 9059746 27.26 µM -0.695666755997143 0.247001327765887 no 2552 0.243318774657209 840 6471769
SGTC_1603 st002045 67.8 µM -0.697346901337587 0.246486174861931 no 2553 0.242792861496253 843 5887985
SGTC_1606 st000094 49.2 µM -0.697903707078214 0.246315578572974 no 2554 0.242618707952296 812 1242210
SGTC_749 1000-0129 128 µM -0.697963075586633 0.246297392755358 no 2555 0.242600143104636 840 708470
SGTC_3102 9121669 49.47 µM -0.69838847830055 0.24616710405402 no 2556 0.24246713992465 846 41905072
SGTC_2644 guaiazulene 100 µM -0.699349766706733 0.245872825050567 no 2557 0.242166736326902 823 3515 A coloring agent.
SGTC_2396 5342950 42.78 µM -0.699738445263052 0.245753892598832 no 2558 0.242045331194549 833 1886677
SGTC_3256 9138902 49.47 µM -0.699931619553343 0.245694794341836 no 2559 0.241985004797521 865 17228773
SGTC_2369 9071472 200 µM -0.700198085904769 0.245613286200583 no 2560 0.24190180340865 847 17296037
SGTC_873 0591-4978 488 µM -0.700945463346631 0.245384751935872 no 2561 0.241668525290076 848 3305145
SGTC_712 r015-0009 80.6 µM -0.701182496333324 0.245312295488555 no 2562 0.241594565954014 841 6813872 YLR060W FRS1
SGTC_306 1672-3436 11.6 µM -0.701489384096521 0.24521850285932 no 2563 0.241498828699906 855 6797378
SGTC_936 3005-4620 401 µM -0.701859401432164 0.245105441886503 no 2564 0.241383424835011 840 777207
SGTC_83 0170-0301 39.027 µM -0.704689081180597 0.244241744389748 no 2565 0.240501873893212 838 3089716
SGTC_2348 9022543 33.42 µM -0.705013508530548 0.244142825025304 no 2566 0.240400914799839 838 3162678 YDL140C RPO21
SGTC_2220 6782180 200 µM -0.70538741564928 0.244028845858555 no 2567 0.240284586654229 831 833803
SGTC_1627 st003713 25.6 µM -0.705398254965081 0.244025542107355 no 2568 0.240281214837065 847 16195070 YER133W GLC7
SGTC_2491 paeonol 100 µM -0.705946956157624 0.243858333169218 no 2569 0.240110562466808 841 11092 Increases levels of cortical cytochrome oxidase.
SGTC_3007 9078383 71.4286 µM -0.706037178655187 0.243830845057935 no 2570 0.240082508560583 832 6496995
SGTC_476 mead acid 10 µM -0.706740457196273 0.243616634339441 no 2571 0.239863891436803 857 5312531 An omega 9 fatty acid.
SGTC_2477 5967686 25.23 µM -0.707009059093921 0.243534848054931 no 2572 0.239780424060508 836 776118
SGTC_2117 5521686 200 µM -0.707843735130718 0.243280793178821 no 2573 0.239521151706698 836 803312
SGTC_1368 1852-0141 284 µM -0.708130645546917 0.243193497792741 no 2574 0.239432065139459 843 2838987
SGTC_1173 0443-0020 122 µM -0.709416455933758 0.242802485115693 no 2575 0.239033039406202 833 5331295
SGTC_1244 0416-0015 52.5 µM -0.710069082135901 0.242604152885445 no 2576 0.238830648988559 835 96201
SGTC_65 0798-0905 34.986 µM -0.710110637236665 0.242591527317302 no 2577 0.238817765224248 870 3602145
SGTC_2598 perillyl alcohol 100 µM -0.710240554612427 0.242552057185482 no 2578 0.238777488028145 840 10819 An apoptosis inducer.
SGTC_505 gw-5074 63.9 µM -0.710892643318543 0.242353998995186 no 2579 0.238575382572821 840 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_608 k048-0125 159 µM -0.712466292787468 0.241876397289523 no 2580 0.238088038549727 834 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_933 2914-0560 114 µM -0.712504448648782 0.241864823351966 no 2581 0.238076228827029 826 463887
SGTC_1990 st072050 59.8 µM -0.713959265999023 0.241423753250472 no 2582 0.237626183987336 834 17233948
SGTC_1294 1000-1494 117 µM -0.714259825647341 0.241332684359379 no 2583 0.237533264678054 830 712797 YDL207W GLE1
SGTC_2739 tacrine 100.86 µM -0.715949690504012 0.240821006805941 no 2584 0.23701120712359 824 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2762 leflunomide 42.06 µM -0.716039774740241 0.240793746601812 no 2585 0.236983394710676 855 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1091 telmisartan 47.6 µM -0.716572310822918 0.240632631267356 no 2586 0.236819017320509 855 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1942 st076330 65.2 µM -0.720294932473457 0.239508016861566 no 2587 0.235671712086435 854 24208414
SGTC_44 0929-0055 61.211 µM -0.720673478442367 0.239393818030345 no 2588 0.235555216867323 838 1379590
SGTC_2845 9003024 42.97 µM -0.721941024569092 0.239011644381959 no 2589 0.235165368646562 828 2990173
SGTC_654 1124-0271 80.9 µM -0.723438000013618 0.23856072617021 no 2590 0.234705416093905 842 5403748
SGTC_1044 1222-0021 1.78 µM -0.723793992394051 0.238453562893599 no 2591 0.234596109061157 828 4306703
SGTC_3224 9130643 49.47 µM -0.724156785292728 0.238344379600522 no 2592 0.234484742910556 834 17644395
SGTC_1906 st060206 94.7 µM -0.725676167245129 0.237887415963588 no 2593 0.234018657737016 855 5133468
SGTC_534 k292-0788 63.4 µM -0.726582306480749 0.23761511776802 no 2594 0.233740935187436 874 4146317
SGTC_1814 st052110 31.539 µM -0.732450709556497 0.235855788137796 no 2595 0.231946758626613 845 674163
SGTC_961 1252-1571 372 µM -0.732548876254714 0.235826419249399 no 2596 0.231916810986443 858 6813498
SGTC_1335 1486-0900 202 µM -0.733241391311252 0.235619294288939 no 2597 0.231705607132584 839 X1335
SGTC_1859 st055998 20 µM -0.734763052703914 0.235164531882569 no 2598 0.231241906187397 854 676301
SGTC_1678 st019265 80.2 µM -0.735044611097249 0.235080438760471 no 2599 0.23115616275383 834 5367020
SGTC_637 1181-0519 7.26 µM -0.735620033615241 0.234908628834484 no 2600 0.230980983591815 852 6252091 YGR060W ERG25
SGTC_1409 3909-8004 61.9 µM -0.737011725683619 0.234493383773479 no 2601 0.230557609361267 839 2119279
SGTC_1717 st033143 58.0435 µM -0.737252842140441 0.234421482128859 no 2602 0.230484302111911 849 674616
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.740798955205282 0.233365430869391 no 2603 0.229407674384017 849 4330530
SGTC_716 1683-5115 658 µM -0.744424595435514 0.23228843060291 no 2604 0.228309821899666 858 723597
SGTC_2625 euphol 100 µM -0.744838564703855 0.232165636741946 no 2605 0.22818465912236 844 6708538 A triterpene alcohol.
SGTC_825 1988-2224 89.6 µM -0.747339431317182 0.231424584696652 no 2606 0.227429348148086 850 1180859
SGTC_1315 1237-0019 3.69 µM -0.748346823504909 0.231126449230233 no 2607 0.2271254942295 836 825140
SGTC_443 clozapine 122 µM -0.748378085367833 0.231117200781839 no 2608 0.227116068555876 859 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_929 2805-0021 398 µM -0.748648408134998 0.231037237637399 no 2609 0.227034573520386 893 3098024
SGTC_1735 st034310 56.75 µM -0.74933700770031 0.230833615418314 no 2610 0.226827053806984 819 871153
SGTC_2371 9071574 200 µM -0.749418660468173 0.230809476948629 no 2611 0.226802453630537 867 45596039
SGTC_3115 9123671 49.47 µM -0.749452810779719 0.230799381735187 no 2612 0.226792165341984 865 3286988
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.750523613661593 0.230482965569065 no 2613 0.226469703667737 851 1241132 A phosphatase inhibitor.
SGTC_1701 st028638 40.4 µM -0.751123197425849 0.230305897923987 no 2614 0.226289258084332 856 3490878
SGTC_81 0411-0046 9.971 µM -0.751167534775265 0.2302928073451 no 2615 0.226275917921989 849 12925265
SGTC_1609 st001574 46.4 µM -0.751200712071246 0.230283012038254 no 2616 0.226265935872198 867 3960012
SGTC_2357 9067248 200 µM -0.75313018920903 0.229713751724426 no 2617 0.225685842371298 871 9150235
SGTC_411 enrofloxacin 100 µM -0.754696590529278 0.229252191126765 no 2618 0.225215526357951 835 71188 A bacterial gyrase inhibitor.
SGTC_3146 9095609 49.47 µM -0.754765109998157 0.229232012848592 no 2619 0.225194965892877 859 17173999
SGTC_105 0111-0055 734.78 µM -0.75544694609862 0.229031273407987 no 2620 0.224990426986477 854 5179370
SGTC_1450 4112-4260 37.6 µM -0.755583679008349 0.228991029731995 no 2621 0.224949422182433 858 1633175
SGTC_791 1348-1292 225 µM -0.755963087354921 0.228879381811391 no 2622 0.224835663678201 869 5437054
SGTC_1269 0831-0796 3.05 µM -0.756058496736511 0.228851310644982 no 2623 0.224807062090768 838 927758
SGTC_910 3454-3003 490 µM -0.756180817918192 0.228815324367042 no 2624 0.224770395968838 864 820824
SGTC_997 3996-0078 137 µM -0.756566569679483 0.228701858940334 no 2625 0.224654787994164 844 735687
SGTC_2094 5332512 191.667 µM -0.756854952121962 0.228617054468326 no 2626 0.224568383179289 857 755774
SGTC_2905 7799065 20.05 µM -0.758309237673764 0.228189662682524 no 2627 0.224132939204056 832 1296806
SGTC_64 000l-0018 272.079 µM -0.760641749371121 0.227505112913792 no 2628 0.223435538038253 855 6811119
SGTC_1480 1070-0044 41.2 µM -0.761336857115989 0.227301335341414 no 2629 0.22322794575889 853 3124987
SGTC_742 0kpi-0133 140 µM -0.762481165176843 0.226966094468453 no 2630 0.222886440119341 863 2728852
SGTC_783 0848-0141 92.7 µM -0.763461307557677 0.226679170040854 no 2631 0.222594164650505 864 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_152 4469-0003 551.229 µM -0.764601012836204 0.226345793123596 no 2632 0.222254582932953 844 697280
SGTC_3153 9100258 49.47 µM -0.766257550340472 0.225861730975714 no 2633 0.221761535545981 867 25236848
SGTC_357 1325-0123 420 µM -0.767389590971294 0.225531270755857 no 2634 0.221424957720508 877 1098503
SGTC_2373 9071805 200 µM -0.76783390295224 0.225401644014005 no 2635 0.221292934932798 883 10149009
SGTC_285 1486-1325 46 µM -0.768553331983745 0.225191842136998 no 2636 0.221079259407679 867 22310230
SGTC_782 0083-0095 30.5 µM -0.769406668002574 0.224943133415447 no 2637 0.220825965696265 863 3591729 An indicator and reagent.
SGTC_2270 7924575 90.91 µM -0.769773080002364 0.224836388744069 no 2638 0.220717255503414 868 1262135
SGTC_63 0099-0242 26.702 µM -0.769892629318186 0.224801567353657 no 2639 0.220681793240114 866 3898502 YLR359W ADE13
SGTC_2026 5148700 152 µM -0.771205389830274 0.224419397934816 no 2640 0.220292599989016 869 79838
SGTC_2405 ticlatone 3.52 µM -0.771828757714787 0.224238052949069 no 2641 0.220107928407575 882 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1817 st052116 64.4 µM -0.773664468125605 0.223704506948096 no 2642 0.219564618669808 864 4361398
SGTC_2778 tioconazole 65.09 nM -0.774102378719988 0.223577335714565 no 2643 0.219435125458919 864 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2165 5727197 32.143 µM -0.774617015838844 0.223427935314903 no 2644 0.21928299977901 865 1361712
SGTC_2215 7188065 200 µM -0.774944954523639 0.223332763558156 no 2645 0.219186093401528 866 940217
SGTC_2497 7-hydroxyflavone 100 µM -0.775311716808397 0.223226352058667 no 2646 0.219077743761149 878 5281894
SGTC_123 0083-0120 66.675 µM -0.776640849318266 0.22284096275126 no 2647 0.21868534694975 881 16001701
SGTC_2046 4110841 106 µM -0.777346776035787 0.222636429642285 no 2648 0.218477102381337 865 44119630 YMR134W ERG29
SGTC_1208 2323-2347 50.3 µM -0.777407317613637 0.222618893489341 no 2649 0.218459248261291 856 5412760
SGTC_1291 0993-0025 5.79 µM -0.778220640001586 0.222383387188803 no 2650 0.218219475478824 864 4353356
SGTC_3336 9143619 71.43 µM -0.778832575964711 0.222206288232119 no 2651 0.218039172750433 882 45595730
SGTC_2419 paclitaxel 166.5 µM -0.779013106064468 0.222154056816234 no 2652 0.217985997206419 869 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1481 3346-2004 36 µM -0.779838604517451 0.221915310853067 no 2653 0.217742940077772 879 2770522
SGTC_1476 4112-3294 3.34 µM -0.780070976836482 0.221848131890836 no 2654 0.217674549323988 841 704369
SGTC_237 nikkomycin 200 µM -0.783280425296095 0.220921467495845 no 2655 0.216731227754905 886 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2426 5582046 32.21 µM -0.785399968962055 0.220310708241451 no 2656 0.216109549480663 864 2251934
SGTC_201 4262-0159 12.803 µM -0.78554355268767 0.22026936876699 no 2657 0.21606747266712 866 1341029
SGTC_2229 7354935 190 µM -0.786317981392488 0.220046478167472 no 2658 0.215840610310653 872 318112
SGTC_338 4055-0136 114 µM -0.786390315097491 0.22002566620058 no 2659 0.215819427813247 867 2900563
SGTC_701 4424-0219 185 µM -0.787776528333157 0.219627041008914 no 2660 0.215413716320677 863 2911779
SGTC_3192 9110362 49.47 µM -0.789159911989413 0.219229643287227 no 2661 0.21500927442902 887 16649480
SGTC_188 3229-0966 278.469 µM -0.78970854166106 0.2190721557155 no 2662 0.214849000897755 864 5722370
SGTC_725 1497-0963 19 µM -0.789717944165667 0.219069457235017 no 2663 0.214846254708939 854 3549977
SGTC_1923 st058458 19.1 µM -0.791470643644298 0.218566773598028 no 2664 0.214334700178985 890 3534982
SGTC_1690 st023502 41.2 µM -0.791615081886107 0.218525377573779 no 2665 0.214292575092634 859 24207482
SGTC_1930 st074634 34.3 µM -0.792641035077532 0.218231469165859 no 2666 0.213993496789577 884 684253 YOR116C RPO31
SGTC_2984 9022109 38.96 µM -0.792667947339569 0.218223762582842 no 2667 0.213985654797323 894 6459207
SGTC_2897 9048598 12.99 µM -0.792777650652039 0.21819234961514 no 2668 0.213953689964918 872 6467404
SGTC_1234 0326-0494 15.5 µM -0.793380193285481 0.218019861162404 no 2669 0.213778173510355 870 1547813
SGTC_3332 9141069 11.198 µM -0.793873179162496 0.217878793752235 no 2670 0.213634632564552 871 17332883
SGTC_2372 9071633 200 µM -0.794749939586196 0.217628039744324 no 2671 0.213379488127078 870 21321366
SGTC_3200 9114385 49.47 µM -0.797258030899085 0.216911644391442 no 2672 0.21265059471641 850 17018030 YLR208W SEC13
SGTC_3079 9117512 49.47 µM -0.797398227549825 0.216871639776131 no 2673 0.212609894171581 920 7185044
SGTC_8 0354-0001 70 µM -0.797544805889345 0.216829818729908 no 2674 0.212567345821308 865 4993152
SGTC_631 k072-0230 41.5 µM -0.798100595930591 0.21667128568014 no 2675 0.212406057830418 897 5773147
SGTC_781 4335-2806 94.4 µM -0.798859648030192 0.216454882681964 no 2676 0.212185899576672 911 845254
SGTC_564 3555-0129 330 µM -0.799842139631215 0.216174963697609 no 2677 0.211901132286314 852 563260
SGTC_2245 6637752 200 µM -0.80103814603883 0.215834495860899 no 2678 0.21155478135054 886 681890
SGTC_2931 9014674 55.67 µM -0.801757343745317 0.215629911145504 no 2679 0.211346668895985 889 2996810
SGTC_315 k915-0449 187 µM -0.803643917958623 0.215093786333442 no 2680 0.210801325794581 855 20970215 YNL149C PGA2
SGTC_634 1611-4317 11.2 µM -0.80466169770967 0.214804876343793 no 2681 0.210507464049619 886 2843522
SGTC_1520 flindersine 88 µM -0.805584634890552 0.214543083673108 no 2682 0.210241194012673 877 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.80805564216457 0.213843092090313 no 2683 0.209529275711157 890 364106
SGTC_1251 0490-5699 265 µM -0.808635802127795 0.213678936272309 no 2684 0.209362332463068 860 3883818
SGTC_2793 7325131 81.82 µM -0.808829055086096 0.213624271798388 no 2685 0.209306740569515 857 4176441
SGTC_709 3807-1509 243 µM -0.80884487433544 0.213619797449192 no 2686 0.209302190327778 905 1886677 YPL242C IQG1
SGTC_1482 3346-2049 8.48 µM -0.809079552984309 0.213553426868224 no 2687 0.209234694305891 856 3826804
SGTC_1312 1218-2183 165 µM -0.811677334956018 0.21281953891792 no 2688 0.208488401494947 864 6744073
SGTC_1136 pergolide 1.05886 µM -0.814028987535282 0.21215645522689 no 2689 0.20781417247665 867 47811 A dopamine receptor agonist.
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.814223395662062 0.212101693047441 no 2690 0.207758492509061 896 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1420 4'-methoxyflavone 42 µM -0.816498581431472 0.21146141814874 no 2691 0.207107517268461 849 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1284 0929-0043 16 µM -0.817316587972203 0.211231494490772 no 2692 0.2068737647858 884 1239883
SGTC_2999 9069765 71.4286 µM -0.817645965431722 0.211138955107076 no 2693 0.206779686427598 857 2097066
SGTC_148 3253-0744 288.01 µM -0.819910410431153 0.21050339731139 no 2694 0.206133590808256 877 6893655
SGTC_2407 paclitaxel 400 µM -0.820625876790288 0.210302822294698 no 2695 0.205929701726985 918 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2654 protoveratrine a 100 µM -0.820897367907422 0.210226741408729 no 2696 0.205852365224194 890 5702278 A heart drug and vasodilator.
SGTC_153 4077-0274 519.67 µM -0.822058636037107 0.209901497754245 no 2697 0.205521762873125 871 3121976
SGTC_2278 7948257 134.34 µM -0.825080362487653 0.209056571102228 no 2698 0.204662983881072 867 1247028
SGTC_2048 5246248 200 µM -0.825537664816888 0.20892887623468 no 2699 0.204533204141291 863 677046
SGTC_2332 7982454 138.89 µM -0.826894062734591 0.208550392662768 no 2700 0.204148554464063 894 2981748
SGTC_604 1000-0114 314 µM -0.827547315481716 0.20836825608343 no 2701 0.203963457737144 885 1572745
SGTC_2383 9036125 200 µM -0.8302267446915 0.207622173667145 no 2702 0.203205298386816 880 79580
SGTC_2606 farnesol 9.78 µM -0.831344693802214 0.207311349947602 no 2703 0.20288946648065 888 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_5 0352-0601 109.883 µM -0.832661162982257 0.206945684627541 no 2704 0.202517926834981 873 762456
SGTC_935 2996-0153 430 µM -0.832785613082826 0.206911136857025 no 2705 0.20248282504299 864 23738523
SGTC_1597 7-benzyloxygramine 47.5 µM -0.833461657721417 0.206723524213046 no 2706 0.202292206729053 873 260807
SGTC_548 1436-0017 110 µM -0.833601859308176 0.206684628759711 no 2707 0.202252688772587 870 9677137
SGTC_215 1287-0124 461.5 µM -0.833925802676446 0.206594775281387 no 2708 0.202161398054938 888 5560863
SGTC_2952 9073731 13.78 µM -0.833986931439215 0.206577822345124 no 2709 0.20214417407905 892 16457353
SGTC_864 0469-0573 172 µM -0.836584113972003 0.205858303085665 no 2710 0.201413189089928 911 689425
SGTC_1280 0880-0253 10.1 µM -0.837752800804324 0.20553501762157 no 2711 0.201084776087953 885 6836607
SGTC_2232 chlorophetanol 41.5365 µM -0.838288517698285 0.205386926907122 no 2712 0.200934341555507 885 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1131 3454-3128 32.3 µM -0.841607366652933 0.204470895365934 no 2713 0.200003882232202 872 710982
SGTC_870 0573-2213 57.6 µM -0.842076688371084 0.204341554962192 no 2714 0.199872514439924 867 3916321
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.842290419691131 0.204282668879025 no 2715 0.199812706130236 908 689007
SGTC_2639 lactacystin 53 µM -0.843813269462805 0.203863394199649 no 2716 0.199386879649612 865 3870 A proteasome inhibitor.
SGTC_2603 homopterocarpin 100 µM -0.843828971128526 0.203859073852124 no 2717 0.199382491923036 891 101795 A weak amylase inhibitor.
SGTC_1405 3909-7894 12 µM -0.843958466793468 0.203823444918738 no 2718 0.199346307433275 854 7104060
SGTC_1950 st077106 7.18 µM -0.844469660147761 0.203682833417833 no 2719 0.199203505202143 868 13831864
SGTC_880 0833-0487 87.2 µM -0.84534006128538 0.203443549479343 no 2720 0.198960499835259 892 76075
SGTC_832 4083-0019 164 µM -0.849080521170814 0.202417161638629 no 2721 0.197918244213774 891 1990758
SGTC_1972 st070201 17.4 µM -0.850775288050273 0.201953136170969 no 2722 0.197447095781046 894 2829099
SGTC_2682 pyrogallin 40.03 µM -0.851454503993512 0.201767346404472 no 2723 0.197258462977549 871 822798 An ATP competetive kinase inhibitor.
SGTC_1210 3013-0140 750 nM -0.853711925679886 0.201150596932334 no 2724 0.196632312367081 881 905973
SGTC_942 3253-1115 227 µM -0.854988361380574 0.200802363247911 no 2725 0.196278795489496 895 46497897
SGTC_450 aminopyrene 156 nM -0.855102601205235 0.200771214302354 no 2726 0.196247174850415 876 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_3158 9100007 49.47 µM -0.855555197321573 0.20064783670485 no 2727 0.19612193034702 902 19297233
SGTC_2444 5485484 36.41 µM -0.856971404075388 0.200262073224648 no 2728 0.195730344291665 921 6790631
SGTC_3041 9091929 49.47 µM -0.857068330299325 0.200235687594822 no 2729 0.195703561219523 880 25236887
SGTC_2871 9038510 12.99 µM -0.858217316625139 0.199923065304532 no 2730 0.195386237889445 893 4945164
SGTC_1212 0520-0165 585 µM -0.859893839657232 0.199467434974027 no 2731 0.194923782315061 917 5403258
SGTC_711 k292-0785 179 µM -0.861434704142407 0.199049224444239 no 2732 0.194499334596296 867 4146315
SGTC_2915 7971052 15.16 µM -0.861667370939824 0.198986121611024 no 2733 0.194435292940264 850 5741558
SGTC_3157 9099274 49.47 µM -0.861767655025265 0.198958926734573 no 2734 0.194407693653144 863 17217662
SGTC_1444 4112-3581 28 µM -0.866697645702492 0.197624782999784 no 2735 0.19305384787033 900 2877249
SGTC_1605 st000082 49.1 µM -0.867283711594825 0.197466543497268 no 2736 0.19289328954531 876 1114022
SGTC_1903 st060211 78.3 µM -0.868799392981692 0.197057660519485 no 2737 0.192478432599427 872 688960
SGTC_3205 9113483 49.47 µM -0.869108988855966 0.196974204394029 no 2738 0.192393760292913 899 17018033
SGTC_516 3992-2719 87.3 µM -0.871274986826112 0.196390926421284 no 2739 0.191802012296865 915 5350887 YDR037W KRS1
SGTC_2490 carminic acid 95.39 µM -0.873340194127849 0.195835766260628 no 2740 0.191238839193602 884 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2290 7904846 200 µM -0.873601792582633 0.195765512508139 no 2741 0.191167574830176 889 2962154
SGTC_533 1222-0222 6.71 µM -0.873641936189271 0.195754733068273 no 2742 0.191156640394161 918 3982874
SGTC_1738 st035555 74 µM -0.874169155596895 0.195613196518512 no 2743 0.191013070381743 897 5331140
SGTC_1787 fluconazole 80 µM -0.875234381640038 0.195327417151005 no 2744 0.190723194694504 859 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2831 7999036 19.48 µM -0.875964871977957 0.195131587537115 no 2745 0.190524565426414 918 2988270
SGTC_1180 1193-0155 285 µM -0.87615352690159 0.195081032381439 no 2746 0.190473288485752 913 2921347
SGTC_1217 1183-1422 255 µM -0.87683301362749 0.194899011647429 no 2747 0.190288672311839 886 2849664
SGTC_395 anisomycin 6.25 µM -0.879438240682088 0.194202081720391 no 2748 0.189581852745049 909 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_415 dibenzyl ketone 100 µM -0.879495702356036 0.194186727151417 no 2749 0.189566281147649 898 7593
SGTC_3277 9138724 49.47 µM -0.88187805327364 0.193550780407532 no 2750 0.188921378233356 871 15943418
SGTC_1321 1326-2144 215 µM -0.881901232045991 0.193544599292879 no 2751 0.188915110381616 915 3513030
SGTC_1287 0971-0001 34.6 µM -0.883291671391934 0.193174029216808 no 2752 0.188539351279163 877 4665869
SGTC_2799 7812892 81.82 µM -0.883512960475522 0.193115092787906 no 2753 0.188479591576952 900 20205235
SGTC_635 k038-0028 24.7 µM -0.884434247154337 0.192869842405058 no 2754 0.188230921245334 909 4035102
SGTC_1883 5-benzylidenerhodanine 20 µM -0.885612765408587 0.192556393387319 no 2755 0.187913115172606 870 1273210
SGTC_2919 7978188 46.38 µM -0.886250654409769 0.192386864809431 no 2756 0.187741236599926 867 2980291
SGTC_2379 9035213 200 µM -0.886403331314425 0.192346302170502 no 2757 0.187700112363091 875 646551
SGTC_2242 6630449 61.2675 µM -0.887392177923069 0.192083715687608 no 2758 0.187433896667281 911 691249 YDR170C SEC7
SGTC_1977 st070720 65.3 µM -0.887618210034181 0.192023724070885 no 2759 0.187373077450445 891 682188
SGTC_2851 9015922 71.43 µM -0.888520302606289 0.191784412167272 no 2760 0.187130469904076 891 2996893
SGTC_1370 2001-0092 44.6 µM -0.88902783832882 0.191649850706862 no 2761 0.186994059381416 885 790957
SGTC_2763 lisinopril 49.32 µM -0.891599495036251 0.19096892408432 no 2762 0.18630382046001 892 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1277 0873-0036 22 µM -0.892169333133028 0.190818242690745 no 2763 0.186151088446535 906 5965735
SGTC_3259 9138485 49.47 µM -0.895207703528486 0.190016043291069 no 2764 0.185338033735927 893 17646153
SGTC_2040 5100729 123 µM -0.895957961116284 0.189818277673544 no 2765 0.185137608005695 889 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1905 st060207 84.5 µM -0.896431953794841 0.189693399910538 no 2766 0.185011053810168 879 1948547
SGTC_1720 st037298 9.481 µM -0.896882916237 0.18957463659696 no 2767 0.184890698504753 918 597396
SGTC_265 mycophenolic acid 32.932 µM -0.897242929578592 0.189479858049099 no 2768 0.184794651124631 909 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_553 k007-0256 45.7 µM -0.897578138932738 0.18939163571757 no 2769 0.184705249048328 895 6287000
SGTC_2524 avocatin b 10.57 µM -0.901177339857309 0.188445971030848 no 2770 0.183747018563154 875 6710748
SGTC_1920 st075728 45.7 µM -0.901981112532242 0.188235183886449 no 2771 0.183533450538667 863 3400306
SGTC_621 3584-0052 32.1 µM -0.903291578052378 0.18789183005127 no 2772 0.183185582579682 899 2273927
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.904329901411131 0.1876200547127 no 2773 0.182910247984422 912 4213774
SGTC_2356 9061756 188.97 µM -0.905228851583062 0.187384955797468 no 2774 0.182672080008132 888 20104043
SGTC_3300 9124615 50.48 µM -0.905565308383797 0.18729701042278 no 2775 0.182582988921439 917 24824903
SGTC_1679 SEC14.276 6.7 µM -0.90662504771927 0.18702017533526 no 2776 0.182302555744133 898 1005053 YMR079W SEC14
SGTC_1600 coumarin 106 71.1 µM -0.907486672725386 0.186795280212854 no 2777 0.182074746998308 909 100336 A hepatotoxic, DNA x-linker.
SGTC_1125 tnp00248 1.32998 µM -0.911236648347331 0.185818439568497 no 2778 0.181085349006885 908 24207736
SGTC_2310 7668677 200 µM -0.91188298719363 0.185650393799207 no 2779 0.180915159134647 911 2197143
SGTC_130 0136-0219 337.655 µM -0.91569408369226 0.184661440717907 no 2780 0.179913684482574 916 234244
SGTC_576 1073-0113 22.7 µM -0.917480591906625 0.184198983967749 no 2781 0.179445429235439 927 5439563
SGTC_807 1315-0151 48 µM -0.917663258043257 0.184151739537719 no 2782 0.179397594481534 927 4011080
SGTC_1834 st055981 52.8 µM -0.918111827282088 0.184035754429916 no 2783 0.179280161741642 891 471719 YDL150W RPC53
SGTC_2665 lovastatin 100 µM -0.922514233092122 0.182899853299201 no 2784 0.178130204830662 910 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1200 1643-0193 18.4 µM -0.922736852313619 0.182842529935485 no 2785 0.178072178011355 909 5403974
SGTC_2160 5660466 132.927 µM -0.92319682964726 0.182724123542383 no 2786 0.177952320361875 935 2859134
SGTC_3156 9099931 49.47 µM -0.92377026531479 0.182576578002567 no 2787 0.177802969802712 922 18111053
SGTC_939 1165-0479 45.3 µM -0.923799550700278 0.182569044842678 no 2788 0.177795344585633 898 1377347
SGTC_2308 7584454 197.62 µM -0.925795245820286 0.182056144135334 no 2789 0.177276199169797 913 893577
SGTC_1391 3442-0225 151 µM -0.926666230935285 0.181832580537846 no 2790 0.177049927883983 896 5227075
SGTC_363 0455-0021 3.06 µM -0.926798916853523 0.181798537926588 no 2791 0.177015473727136 896 4597466
SGTC_707 0865-0008 204 µM -0.929905782482903 0.18100256372265 no 2792 0.176209934396192 929 723043
SGTC_299 1273-0059 1.44 µM -0.929992915288693 0.180980271957671 no 2793 0.176187376345237 887 2848077
SGTC_1009 4106-0057 9.87 µM -0.930465772278327 0.180859327813045 no 2794 0.176064988979358 887 2928005
SGTC_2457 5731572 11.68 µM -0.93122631865798 0.180664906728516 no 2795 0.175868253244854 904 2865357
SGTC_19 0279-0214 38.434 µM -0.931356543933758 0.18063162993939 no 2796 0.17583458094815 920 3566274 YBR002C RER2
SGTC_2689 tacrolimus 100 µM -0.932472715433737 0.180346569528772 no 2797 0.175546140447891 886 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_689 0833-0039 98 µM -0.932897448903044 0.180238170509485 no 2798 0.175436459840211 934 5374726
SGTC_1199 1638-0010 4.46 µM -0.935745999076829 0.179512230440941 no 2799 0.174701990454163 908 3111136
SGTC_3131 9127911 49.47 µM -0.936905346895913 0.179217302860084 no 2800 0.174403624287916 897 45595681
SGTC_3110 9122132 49.47 µM -0.937216062430666 0.179138311456135 no 2801 0.174323714535864 901 918317
SGTC_1400 3771-8998 51.5 µM -0.937801632412701 0.17898950494457 no 2802 0.174173181021422 893 670767
SGTC_398 bronopol 33.3 µM -0.938150083832136 0.178900992521121 no 2803 0.174083643216951 899 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1954 st077032 68.9 µM -0.938367195609479 0.178845856470804 no 2804 0.174027869142105 926 698907
SGTC_2461 5755302 26.15 µM -0.940519811146099 0.178299773514058 no 2805 0.173475496272578 954 2788904
SGTC_1016 4226-1401 38 µM -0.941188902951696 0.178130250267437 no 2806 0.17330403125222 901 2901613
SGTC_3273 9137859 49.47 µM -0.941434304577447 0.17806809999877 no 2807 0.173241170383199 959 2377234
SGTC_1958 st076513 41.9 µM -0.941504546378337 0.178050313119261 no 2808 0.173223180263253 924 732122 YGL099W LSG1
SGTC_2061 5245884 80.95 µM -0.941769450330477 0.177983243273837 no 2809 0.173155344559277 924 573863
SGTC_1790 st045711 43.5 µM -0.9437323428174 0.177486763802289 no 2810 0.172653220988944 858 585119
SGTC_3225 9130819 49.47 µM -0.945627295159966 0.177008298783961 no 2811 0.172169358651904 921 4547121
SGTC_1014 4130-3005 69.3 µM -0.948682004632133 0.176238719086035 no 2812 0.171391184589824 925 743608
SGTC_2794 7785382 27.27 µM -0.949122057587361 0.176128030322284 no 2813 0.171279268543241 890 2205081
SGTC_891 0929-0073 133 µM -0.949140015014689 0.176123514333741 no 2814 0.171274702530161 929 5603632
SGTC_1634 st006576 41 µM -0.95265476963838 0.175241024518216 no 2815 0.170382508630204 902 3915356
SGTC_2228 7354201 200 µM -0.954176820785242 0.174859737273574 no 2816 0.169997072784163 937 753451
SGTC_319 1348-1596 45.5 µM -0.954953843047851 0.174665289500829 no 2817 0.169800519614138 914 5380505
SGTC_1713 st033146 12.748 µM -0.955048971667081 0.17464149325098 no 2818 0.169776466187039 930 674619
SGTC_1835 st008666 49.2 µM -0.956212149858458 0.174350692840375 no 2819 0.169482531398408 905 690455
SGTC_3319 9138450 16.7555 µM -0.957475505371796 0.174035196329863 no 2820 0.169163651999344 895 2029690
SGTC_38 0929-0051 58.268 µM -0.95855122214268 0.173766844933935 no 2821 0.168892437737596 919 1379719
SGTC_3075 9116269 49.47 µM -0.959203341269705 0.173604293635632 no 2822 0.168728158787179 899 17015205 YNL244C SUI1
SGTC_2583 asiatic acid 100 µM -0.96037305624835 0.173312965669337 no 2823 0.168433746783561 927 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_3016 9080866 49.47 µM -0.962776147779134 0.172715431498758 no 2824 0.167829936579863 920 17066299
SGTC_2920 7982904 15.77 µM -0.965900825136164 0.171940439854919 no 2825 0.167046904714901 917 6456808
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.966766726578176 0.171726069936675 no 2826 0.166830330761485 943 5106787 A p450 inhibitor.
SGTC_23 0213-0011 39.996 µM -0.969112671181593 0.171146146195619 no 2827 0.166244488111743 927 627608
SGTC_176 1486-1328 72.834 µM -0.971105380903593 0.170654527999289 no 2828 0.165747902272782 913 22310231
SGTC_3228 9131799 49.47 µM -0.971358129156588 0.170592237551408 no 2829 0.16568498568463 927 17015818
SGTC_3288 9119690 36.221 µM -0.971455075330834 0.170568348783977 no 2830 0.165660856984876 960 17595618 YKL019W RAM2
SGTC_366 0181-0206 4.31 µM -0.974281464740337 0.169872832168594 no 2831 0.164958402602764 942 274874
SGTC_31 0508-1974 57.237 µM -0.975924798300806 0.16946927858242 no 2832 0.164550866094583 888 6810525
SGTC_2973 9094665 17.96 µM -0.975970345154944 0.16945810240554 no 2833 0.164539580058769 904 25237061 YIL048W NEO1
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.978038085458912 0.168951223460431 no 2834 0.164027743941818 930 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_90 0870-0863 4.608 µM -0.978412372034465 0.168859576310004 no 2835 0.16393520579882 948 1738164
SGTC_1396 3511-0007 98.6 µM -0.978755756379948 0.168775523924141 no 2836 0.163850337685642 897 X1396
SGTC_2860 9025725 38.96 µM -0.980883524535591 0.168255296056788 no 2837 0.163325091493307 945 40546248
SGTC_2446 5162541 200 µM -0.981247781817413 0.168166340628082 no 2838 0.163235283229575 928 1549321
SGTC_2294 7971431 200 µM -0.983032262264561 0.167730989199395 no 2839 0.162795780232461 961 5741572
SGTC_484 loperamide 105 µM -0.983655600905189 0.167579087348065 no 2840 0.162642438533482 899 3955 An opioid-receptor agonist.
SGTC_599 1935-0052 86.5 µM -0.984205591201793 0.167445133418282 no 2841 0.162507218626602 922 9557311
SGTC_2837 9008476 45.46 µM -0.985574792283706 0.167111954810712 no 2842 0.162170906453114 908 2992805
SGTC_2037 5169046 200 µM -0.9918391898674 0.165593045030801 no 2843 0.160637988464932 921 5718022
SGTC_1379 2144-0755 36.5 µM -0.99229369737853 0.165483190431286 no 2844 0.160527138458731 934 5392327
SGTC_3193 9111931 49.47 µM -0.99318875521914 0.165266992549908 no 2845 0.160308988603122 949 17087244
SGTC_1416 3966-0321 25.3 µM -0.995327641534483 0.164751093210652 no 2846 0.159788469108366 921 582530 YLR208W SEC13
SGTC_720 r052-1644 49.9 µM -0.996263712114529 0.164525641557418 no 2847 0.15956101515135 935 1422863 YOR257W CDC31
SGTC_2767 sibutramine 71.45 µM -0.997609630664019 0.164201829042574 no 2848 0.159234344624989 930 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1973 st070275 50.2 µM -0.999360559355496 0.163781194766995 no 2849 0.158810029316511 919 17118334
SGTC_987 1497-1013 404 µM -1.00004174657479 0.163617738928816 no 2850 0.15864515269336 936 1676435
SGTC_3302 9125395 16.351 µM -1.00070243850768 0.163459302304843 no 2851 0.158485344073399 909 17599668
SGTC_2148 5546263 113.568 µM -1.00099491567028 0.163389196916112 no 2852 0.158414633224095 949 792097
SGTC_2796 7949634 45.45 µM -1.00262194695947 0.162999561820888 no 2853 0.158021651251752 927 2971588
SGTC_1070 indatraline 8.81 µM -1.00279578855395 0.162957966661273 no 2854 0.157979700622279 925 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_3219 9131112 49.47 µM -1.00306952084114 0.162892484598117 no 2855 0.157913659666837 911 17612988 YMR079W SEC14
SGTC_919 tnp00227 403.569 nM -1.00398350123412 0.162673966744626 no 2856 0.157693283076498 948 1269246 A methoxyflavone. YNL221C POP1
SGTC_558 k064-0027 21.3 µM -1.00507471957748 0.162413324034259 no 2857 0.157430436054475 899 5088526
SGTC_1924 st058459 75.1 µM -1.00533316866002 0.162351632069177 no 2858 0.15736822437942 920 688683
SGTC_1421 4029-0249 71.4 µM -1.00535345891788 0.162346789417189 no 2859 0.157363340964569 931 2894095
SGTC_2382 9035899 200 µM -1.00637850129911 0.16210226611688 no 2860 0.157116765640627 932 6462679
SGTC_1058 3448-5425 97.3 µM -1.00658413258542 0.162053241784592 no 2861 0.157067331374062 913 7279705
SGTC_1946 st076057 65.1 µM -1.01018697870022 0.16119585812147 no 2862 0.156202858297711 909 953009
SGTC_88 0180-0332 8.668 µM -1.01590693125759 0.159840748421948 no 2863 0.154836853945431 932 3101745
SGTC_1233 0325-0408 14.2 µM -1.0160620115126 0.159804112534422 no 2864 0.154799928828285 933 12874
SGTC_2118 5526350 200 µM -1.01795325675128 0.159357770106472 no 2865 0.154350085233361 939 743594
SGTC_1760 st045453 10.4495 µM -1.02028480705895 0.158808638242439 no 2866 0.153796703328697 945 3323419 YIL048W NEO1
SGTC_962 1254-0300 21.5 µM -1.02220739681014 0.158356759860739 no 2867 0.153341375319771 917 7340576
SGTC_362 0310-0100 9.03 µM -1.02354831883019 0.158042094344699 no 2868 0.153024333196749 935 790235
SGTC_260 nsc-65238 3.989 µM -1.02575125420201 0.157526037405613 no 2869 0.152504424145769 941 3246252
SGTC_326 k292-0812 17.5 µM -1.02688663811331 0.157260496675311 no 2870 0.152236923414353 911 3579357
SGTC_3022 9087993 49.47 µM -1.02718708567533 0.157190278027655 no 2871 0.152166188991154 941 17173644
SGTC_2325 6158266 200 µM -1.03055461131679 0.15640465262427 no 2872 0.151374865059457 934 3623240
SGTC_192 3455-0609 60.9 µM -1.03365118552368 0.155684524786789 no 2873 0.150649630609921 929 3769639
SGTC_54 0159-0055 9 µM -1.03568153955181 0.155213541955403 no 2874 0.150175368713621 933 3319099
SGTC_1075 aripiprazole 15.2 µM -1.03640177439262 0.15504669474118 no 2875 0.150007371459036 946 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1158 4092-0494 91.8 µM -1.03677312790084 0.15496071450935 no 2876 0.149920800955082 938 1148199
SGTC_852 0418-0143 439 µM -1.03928224867989 0.154380597980038 no 2877 0.149336744043263 906 5369229
SGTC_444 curcumin 90.4 µM -1.04093916281586 0.153998302461573 no 2878 0.148951892163195 927 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2324 6149169 200 µM -1.0409931667764 0.153985852816915 no 2879 0.148939359809751 936 2888231
SGTC_2676 harmalol 100 µM -1.04133674270838 0.153906663143332 no 2880 0.148859644841408 924 5459187 A monoamine oxidase inhibitor
SGTC_592 k241-0073 46.5 µM -1.04251157774077 0.153636082996433 no 2881 0.148587280267891 941 4230158
SGTC_3035 9091303 49.47 µM -1.04404366237403 0.153283696993843 no 2882 0.148232594593997 957 25237002
SGTC_563 tetrahydrosecaminediol 614 µM -1.04612622685706 0.152805557649867 no 2883 0.147751378922776 950 334274 A psychoactive constituent of the cannabis plant.
SGTC_1523 st012844 44.7 µM -1.04682341350578 0.152645710670937 no 2884 0.147590514831056 953 4274103
SGTC_435 c-PAF 6.7 µM -1.04817162587066 0.152336915001239 no 2885 0.14727977041311 922 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2526 patulin 37.61 µM -1.0484239797063 0.152279161773898 no 2886 0.147221655080015 945 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.04942755749492 0.152049628696966 no 2887 0.14699069023346 939 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3109 9122853 49.47 µM -1.05009561105178 0.151896962428799 no 2888 0.146837078205905 965 1234709
SGTC_1147 3809-1045 12.3 µM -1.05188319039427 0.151488958625576 no 2889 0.146426572519371 930 325925
SGTC_979 1426-2828 121 µM -1.05260811109086 0.151323707863229 no 2890 0.146260319094634 956 747872
SGTC_1867 st057372 64 µM -1.05448362070063 0.150896728805875 no 2891 0.14583077786535 926 688837
SGTC_2993 9054257 71.4286 µM -1.06083668112581 0.149456353360484 no 2892 0.144382064508474 919 6470217 YGL055W OLE1
SGTC_1473 k844-0725 134 µM -1.06325821645787 0.148909762763116 no 2893 0.14383243404983 940 54682906
SGTC_2820 7989630 71.43 µM -1.06481183418326 0.148559783356937 no 2894 0.143480544369175 902 2984098
SGTC_32 0928-0142 34.1 µM -1.06531723657043 0.148446051332062 no 2895 0.143366197658547 926 2244242
SGTC_2596 sinensetin 100 µM -1.06653882149551 0.148171395389166 no 2896 0.143090069636204 945 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2475 5812728 15.03 µM -1.06724346141757 0.148013121886538 no 2897 0.142930955777362 942 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_3272 9137413 49.47 µM -1.0700732082449 0.147378655068205 no 2898 0.142293178758393 953 17614870
SGTC_669 0108-0021 26.2 µM -1.07249424343103 0.146837275577014 no 2899 0.141749049088196 945 17201
SGTC_1654 st012436 41.8 µM -1.07548910612037 0.146169427729309 no 2900 0.141077903471238 961 4323132
SGTC_2959 9079155 11 µM -1.07570908700037 0.146120453033544 no 2901 0.141028691082652 934 16189457
SGTC_1925 st057770 10.1 µM -1.08031780289752 0.145096941619399 no 2902 0.140000342304887 945 5989122
SGTC_2817 7995342 71.43 µM -1.08127483744513 0.144885008264245 no 2903 0.139787438462184 974 18879975
SGTC_917 harmaline 728.087 nM -1.08193182322062 0.144739640809671 no 2904 0.139641411546999 919 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_381 3461-2219 42.7 µM -1.0826625126503 0.144578080787117 no 2905 0.139479124542017 973 2883159
SGTC_2358 9037157 4 µM -1.08407829496517 0.144265388296919 no 2906 0.139165042794206 937 2388925
SGTC_1799 st045822 46.1415 µM -1.08429553859572 0.144217447811192 no 2907 0.139116891391151 909 3674992
SGTC_1316 1272-0050 65.9 µM -1.08502379209738 0.144056817993373 no 2908 0.138955558902881 947 7340392
SGTC_893 0958-0369 48.9 µM -1.08832954470576 0.143329190163514 no 2909 0.138224826076171 963 6819948
SGTC_2404 5161160 200 µM -1.08874668223429 0.143237550850461 no 2910 0.138132804798628 936 2831543
SGTC_931 2812-0076 566 µM -1.08958011945665 0.143054574825605 no 2911 0.137949072206558 960 3450959
SGTC_3326 9140064 16.379 µM -1.09511865887022 0.141842635134628 no 2912 0.136732327593986 967 1868434
SGTC_1779 st039427 55 µM -1.09605070112992 0.141639371726256 no 2913 0.136528293575913 949 1124498
SGTC_281 1672-3440 14.9 µM -1.09780635460202 0.141257028117682 no 2914 0.136144528029216 950 6833000
SGTC_1435 4092-0789 56.7 µM -1.09786870702419 0.141243461977885 no 2915 0.136130912100124 948 2248285
SGTC_441 propafenone 146 µM -1.09905364333296 0.1409858209253 no 2916 0.135872334121535 958 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2987 9018338 71.43 µM -1.09967407567417 0.140851047361222 no 2917 0.135737076998517 939 5055682
SGTC_2824 7998404 51.95 µM -1.10208101070798 0.140329027786264 no 2918 0.135213227051689 964 837851
SGTC_1322 1348-1070 12 µM -1.10366323385402 0.139986589517966 no 2919 0.13486962497919 933 6758089
SGTC_2440 5628896 157.78 µM -1.10640371998801 0.139394814566212 no 2920 0.134275908054369 966 5522048
SGTC_598 3937-0236 20.2 µM -1.1064077817103 0.139393938751155 no 2921 0.134275029430413 964 1379313
SGTC_869 0564-0080 44.1 µM -1.1068303817376 0.139302835432753 no 2922 0.134183634981536 942 6843321
SGTC_2320 7373003 200 µM -1.10939931298662 0.138749901814827 no 2923 0.133628979311434 938 5415828
SGTC_3271 9137798 49.47 µM -1.10970151484384 0.138684954662257 no 2924 0.133563834959754 891 6498326
SGTC_789 1309-1135 70.6 µM -1.11221069979532 0.138146497651871 no 2925 0.133023784245242 944 3092424
SGTC_758 0868-0029 16 µM -1.11273707175327 0.138033722315423 no 2926 0.132910684457828 926 762687
SGTC_2652 actinonin 100 µM -1.11361128091057 0.137846561533133 no 2927 0.132722992375816 958 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1569 carminic acid 40.6 µM -1.11542339463207 0.137459154936394 no 2928 0.132334514470401 950 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.11663605889708 0.137200318477718 no 2929 0.13207498366757 947 5282309
SGTC_2480 5767542 37.17 µM -1.1168854292561 0.137147133055251 no 2930 0.132021657702361 938 2867358
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.11717338381958 0.137085735962162 no 2931 0.131960099271311 961 6728940
SGTC_2175 5807670 165.306 µM -1.11812022496904 0.136883984801702 no 2932 0.131757824783667 907 241186
SGTC_2585 alliin 100 µM -1.12003729492587 0.136476120740806 no 2933 0.131348934810658 970 87310 A garlic compound which reacts with lipids.
SGTC_294 k038-0071 157 µM -1.12634938748698 0.135139076803475 no 2934 0.130008830428725 966 24152826
SGTC_1145 3546-0597 10.2 µM -1.12659351020828 0.135087547121592 no 2935 0.12995719213313 953 875334
SGTC_48 0382-0018 55 µM -1.12743426460056 0.134910182915595 no 2936 0.129779459404308 980 762596
SGTC_2059 5238311 157 µM -1.13016305787062 0.134335621988961 no 2937 0.129203761467488 958 703021
SGTC_1615 st002656 86.5 µM -1.13409635421491 0.13351040730162 no 2938 0.128377066379535 971 1584458
SGTC_2759 disulfiram 3.38 µM -1.13487858859177 0.133346709226309 no 2939 0.128213096135421 930 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2051 5263410 176 µM -1.13563309087116 0.133188945518203 no 2940 0.128055076885257 956 227584
SGTC_2221 6807166 181.081 µM -1.13867999918431 0.132553154935314 no 2941 0.127418323924333 944 674925
SGTC_3317 9138495 8.753 µM -1.13906330155404 0.132473320526878 no 2942 0.1273383763335 954 17020139
SGTC_1097 itavastatin 7.23 µM -1.14149087922661 0.131968472873685 no 2943 0.126832852687065 950 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_39 0986-0283 58.349 µM -1.14252451002455 0.131753918652361 no 2944 0.126618032009474 934 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1358 1509-0022 2.48 µM -1.14263909517656 0.131730148654754 no 2945 0.126594233258208 957 3258434
SGTC_2464 5717415 7.67 µM -1.14418782217238 0.131409164855804 no 2946 0.126272876176731 957 5285744
SGTC_2184 6075246 200 µM -1.14444456459015 0.131356005534153 no 2947 0.12621965773373 947 2267320
SGTC_574 1315-0397 40 µM -1.14569718676095 0.131096859149639 no 2948 0.125960234145451 975 6794277
SGTC_1758 st042942 75.2445 µM -1.14577466557464 0.131080841697242 no 2949 0.125944200159558 949 669317
SGTC_1479 0549-0158 134 µM -1.14773906181417 0.130675187170028 no 2950 0.125538150248744 979 5440202
SGTC_1880 MG-132 525 µM -1.14775700721971 0.130671485387416 no 2951 0.125534445065132 952 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2690 usnic acid 100 µM -1.14893406795548 0.130428839328359 no 2952 0.125291584261063 985 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2872 9044037 25.97 µM -1.14963008882544 0.130285504303095 no 2953 0.125148129967762 965 6465195
SGTC_801 0866-0028 10.1 µM -1.14981710574631 0.13024700956387 no 2954 0.125109604158357 957 6849771
SGTC_827 3253-0474 693 µM -1.15057371178865 0.130091353431258 no 2955 0.124953826545172 960 5402065
SGTC_1072 oxiconazole 14.9 nM -1.15099392475928 0.130004958883927 no 2956 0.124867367448896 947 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_246 cycloheximide 667 µM -1.15970798480424 0.128222320927852 no 2957 0.123083859058726 957 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2623 humulene 100 µM -1.16079791785813 0.128000553136372 no 2958 0.122862044972123 979 6187145 An anti-inflammatory.
SGTC_1757 st041620 31.8375 µM -1.16190473821826 0.127775622136826 no 2959 0.122637081133004 1000 5289815
SGTC_1783 st039459 87.517 µM -1.16492372083792 0.127163493498425 no 2960 0.122024935363861 984 729761
SGTC_61 0978-8327 98.565 µM -1.16772123597795 0.12659809364258 no 2961 0.121459613988932 955 6150059 YHR072W ERG7
SGTC_257 daunorubicin 18.5 µM -1.16791247495383 0.126559506777987 no 2962 0.121421035795031 937 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_530 4358-1714 28 µM -1.16931575144863 0.126276614054135 no 2963 0.121138219611434 948 1564641
SGTC_359 0081-0058 15.9 µM -1.17825051862784 0.124485750330156 no 2964 0.119348373955526 962 3494159
SGTC_3106 9121286 49.47 µM -1.18059593902439 0.12401859679436 no 2965 0.118881638827787 943 15943471
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.18255991900975 0.123628362173271 no 2966 0.118491802636949 969 688664
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.18271052099153 0.123598473723692 no 2967 0.118461946544835 968 688662
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.18569543916321 0.123007131098939 no 2968 0.117871298166742 953 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2219 9098279 200 µM -1.18570287811878 0.123005659848164 no 2969 0.117869828771849 955 902349
SGTC_1587 estradiol valerate 56.1 µM -1.18678539432681 0.122791695058554 no 2970 0.117656140699923 987 13791 A steroid.
SGTC_1120 ficusin 1.78878 µM -1.19080457951616 0.121999567006985 no 2971 0.116865155342342 980 6199 A DNA cross-linker.
SGTC_2420 aureobasidin a 50 nM -1.19485088924499 0.121205725312571 no 2972 0.116072646772038 977 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_3218 9131285 49.47 µM -1.19541292721983 0.121095747630679 no 2973 0.115962868705381 973 17156417
SGTC_1982 st072467 71.9 µM -1.19569281830393 0.121041005685502 no 2974 0.115908227478193 977 3163533
SGTC_1914 st062367 72.6 µM -1.195893091178 0.121001846397892 no 2975 0.115869140792907 962 978205
SGTC_1792 st045773 43.6 µM -1.19601059260866 0.120978875532127 no 2976 0.115846212730973 917 2919270
SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.19832727529482 0.120526603663673 no 2977 0.115394816100285 990 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.19961098667432 0.120276505782753 no 2978 0.115145228817461 953 5379071
SGTC_2006 4011487 200 µM -1.20242423803862 0.119729695838039 no 2979 0.114599601527963 975 45595294
SGTC_1521 st012942 49.4 µM -1.20327441837585 0.119564792287436 no 2980 0.11443507254951 961 24207259
SGTC_2079 5212404 121 µM -1.20339853580592 0.119540731503518 no 2981 0.114411067114518 978 758462
SGTC_2856 9022925 19.48 µM -1.20368999556208 0.119484244002004 no 2982 0.114354710252549 972 4944862
SGTC_464 bw-b 70c 158 µM -1.20830465977114 0.118592389538932 no 2983 0.113465048376168 982 5353454
SGTC_812 4251-0442 148 µM -1.21338085657093 0.11761678175581 no 2984 0.112492120967723 987 5723007
SGTC_2495 cafestol 54.53 µM -1.21572484120513 0.117168207688724 no 2985 0.112044878956831 975 16667697 An anti-infammatory.
SGTC_692 k241-0027 77.8 µM -1.21722733739376 0.116881309525979 no 2986 0.111758865859759 964 3600480
SGTC_1134 3477-0009 42.5 µM -1.22404249998361 0.115586222237111 no 2987 0.110468097672519 959 3973534
SGTC_2133 5320837 200 µM -1.22542820715759 0.115324147897071 no 2988 0.110206962272481 998 2841355
SGTC_2882 9058044 58.44 µM -1.22614623064735 0.115188516668032 no 2989 0.110071825606273 965 18076804
SGTC_760 0568-0725 82.9 µM -1.22974733232615 0.114509996275752 no 2990 0.109395868114794 986 3916171
SGTC_511 blebbistatin 171 µM -1.23175774293295 0.114132434075547 no 2991 0.109019796379246 991 3476986 A myosin inhibitor.
SGTC_1365 1672-3266 55.4 µM -1.23523577490304 0.113481342967485 no 2992 0.108371384254297 959 6415873
SGTC_2961 9083290 32.55 µM -1.23724906707775 0.113105665190751 no 2993 0.107997315186613 983 17741490
SGTC_1380 2291-0730 164 µM -1.23800239333022 0.112965323874158 no 2994 0.107857586699822 985 2999191
SGTC_200 k038-0079 37.545 µM -1.23860817559717 0.112852559536068 no 2995 0.107745319458513 1005 3436683
SGTC_323 4013-0906 34.3 µM -1.24209954609767 0.112204218709747 no 2996 0.107099918011345 963 2910086
SGTC_3276 9139060 49.47 µM -1.24481296801352 0.111702183106711 no 2997 0.106600254087727 997 4870619
SGTC_2271 7849410 118.62 µM -1.24491100694649 0.11168407413186 no 2998 0.106582232227861 993 972430
SGTC_2821 7996764 71.43 µM -1.24645067203296 0.111399954842811 no 2999 0.106299494039553 956 2987135
SGTC_3155 9099265 49.47 µM -1.24850814259661 0.111021091350303 no 3000 0.105922514183176 988 25236499
SGTC_645 0845-0943 5.41 µM -1.24869110405675 0.110987445485136 no 3001 0.105889037924606 974 1885106
SGTC_1855 st056195 39.6 µM -1.25154649932895 0.110463296131824 no 3002 0.105367579937045 945 4028379
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.2522297677564 0.110338135832224 no 3003 0.105243076001886 990 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_393 acivicin 6.25 µM -1.25434411814672 0.109951475947972 no 3004 0.104858477325097 950 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_3174 9107204 49.47 µM -1.25491933872367 0.109846451456636 no 3005 0.104754021457032 993 3938802
SGTC_1348 1493-0373 93.8 µM -1.25573533346401 0.109697589659728 no 3006 0.104605972052616 992 3010129
SGTC_2264 7948757 110.76 µM -1.25581337715314 0.109683359753075 no 3007 0.104591820198645 986 2971411
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.25584630557058 0.109677356227532 no 3008 0.104585849623819 1007 688798
SGTC_1514 1189-1591 158 µM -1.25616291335556 0.109619644176538 no 3009 0.104528454955294 998 767698 YMR146C TIF34
SGTC_349 k015-0014 24 µM -1.25682656752472 0.109498742412192 no 3010 0.104408221760707 984 2196908
SGTC_1341 1486-1360 280 µM -1.25752782547712 0.109371094232841 no 3011 0.104281284871943 1000 3976547
SGTC_2100 5377183 190 µM -1.25829390719852 0.109231768555584 no 3012 0.104142741912064 958 2844202
SGTC_256 clotrimazole 625 nM -1.26063477445438 0.108806830199156 no 3013 0.103720231897515 958 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1507 4075-3230 155 µM -1.26289401469934 0.108397838051011 no 3014 0.103313635614329 974 659771
SGTC_2641 levomentholum 100 µM -1.26352817481605 0.108283234601634 no 3015 0.103199713863739 987 16666
SGTC_3226 9131256 49.47 µM -1.26385366201412 0.108224447440296 no 3016 0.103141278150462 943 17178073
SGTC_1196 1588-0294 184 µM -1.26583746804913 0.107866643275003 no 3017 0.102785638879998 988 6144269
SGTC_858 0438-0351 2.77 µM -1.26614902764006 0.107810527115785 no 3018 0.102729866283839 990 2799119
SGTC_1694 st024011 44.9 µM -1.26682409705131 0.107689009996642 no 3019 0.102609096890255 994 2787533
SGTC_2718 lomofungin 53.02 µM -1.26820531346625 0.107440689137445 no 3020 0.102362320012121 993 5351222 A RNA synthesis inhibitor.
SGTC_2621 lithochol-11-enic acid 100 µM -1.2716121199269 0.106829964268487 no 3021 0.101755484178979 1007 6708711
SGTC_583 1488-1091 88.9 µM -1.2716331540759 0.10682620135537 no 3022 0.10175174563337 1006 4303273
SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.27355600802298 0.10648261544284 no 3023 0.101410405693946 993 165506
SGTC_629 3448-6466 76.7 µM -1.27398459259802 0.106406142494399 no 3024 0.101334438303449 999 573744
SGTC_1742 st038235 28.8875 µM -1.28105936341719 0.105149507233791 no 3025 0.100086407898271 994 564103 YBR002C RER2
SGTC_3244 9134489 49.47 µM -1.28279462801492 0.104842932808219 no 3026 0.0997820183399265 1003 16584271
SGTC_1648 st011736 69.8 µM -1.28563607286495 0.104342324647433 no 3027 0.0992850506052406 989 2855514
SGTC_1650 st011916 45.8 µM -1.28978048921219 0.103615267267705 no 3028 0.0985634420113979 1004 242528
SGTC_2159 5658611 73.75 µM -1.29305938184254 0.103042659256598 no 3029 0.0979952609871164 990 793844
SGTC_1951 sophoraflavanone G 9.2 µM -1.29389144871138 0.102897717949806 no 3030 0.0978514593298467 977 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1658 st012944 20 µM -1.2982939498003 0.102133292188452 no 3031 0.0970931723153897 994 24207260
SGTC_1143 3454-2408 5.08 µM -1.29975820897369 0.101879964237681 no 3032 0.0968419264857951 949 X1143
SGTC_752 1896-0090 130 µM -1.29981759850287 0.101869699057783 no 3033 0.096831746179446 997 772567
SGTC_2926 9010726 65.15 µM -1.300572337971 0.101739311723931 no 3034 0.096702440317618 1003 2994293
SGTC_2680 butyl paraben 22.24 µM -1.30311694360497 0.101300605971633 no 3035 0.0962674199380098 1016 7184 An antifungal and steroid mimetic.
SGTC_2496 diffractaic acid 79.83 µM -1.30920562994923 0.100256476686629 no 3036 0.0952323528382348 988 94870 An apoptosis inducer which activates caspases.
SGTC_602 3130-1533 38.1 µM -1.31354547518415 0.0995170602749435 no 3037 0.0944996039385549 1002 720941
SGTC_2835 9006588 71.43 µM -1.31492942674112 0.0992821048817127 no 3038 0.0942668109448931 963 2345538
SGTC_2789 5281112 71.43 µM -1.31544364133919 0.0991949093747075 no 3039 0.0941804233274026 980 765948
SGTC_570 0987-0065 62.6 µM -1.32235678410393 0.0980280787220329 no 3040 0.0930246861350055 953 3104428
SGTC_1552 6-methylflavone 10.6 µM -1.32318449354136 0.0978890512754247 no 3041 0.0928870157135323 996 689013
SGTC_2753 fluvastatin 17.09 µM -1.32532189783264 0.0975307075228815 no 3042 0.0925322045298912 1008 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2493 resveratrol 26.09 µM -1.32705462450324 0.0972409162927964 no 3043 0.0922453068986404 972 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_837 0091-0265 12.5 µM -1.32898358864832 0.0969190489277057 no 3044 0.091926692166421 1011 759367
SGTC_2949 9072542 2.23 µM -1.32960347069264 0.0968157815277281 no 3045 0.091824477002277 1008 16457352
SGTC_2850 9015429 58.44 µM -1.33109448345005 0.096567721648268 no 3046 0.091578961962123 1005 6457570
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.334563505677 0.0959923877201231 no 3047 0.0910096244952345 1008 115019
SGTC_1270 0831-1170 17.3 µM -1.33529852581877 0.09587080963498 no 3048 0.0908893304673054 992 6764716
SGTC_2947 9072639 7.68 µM -1.33574343419168 0.095797273354275 no 3049 0.0908165737172041 1020 16488146
SGTC_455 paf C-16 10 µM -1.33880569431622 0.0952922557779273 no 3050 0.0903169682757519 982 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2782 7736369 71.43 µM -1.33931270247094 0.0952088311925508 no 3051 0.0902344476068093 1001 2950836 YOL077C BRX1
SGTC_2732 terfenadine 20 µM -1.34036741486717 0.0950354581001943 no 3052 0.0900629620217766 1030 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2848 9016370 25.97 µM -1.34098631944569 0.0949338312041021 no 3053 0.0899624471841157 979 7894410
SGTC_1992 st073643 23.3 µM -1.34161347594388 0.094830931000659 no 3054 0.089860677233497 1006 3161292
SGTC_1116 jasmonic acid 1.58368 µM -1.34391794952001 0.0944535321381153 no 3055 0.0894874604981783 998 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_3087 9117406 49.47 µM -1.34735948705737 0.0938919822813409 no 3056 0.0889322409066692 988 42546093
SGTC_3330 9141424 71.43 µM -1.34823197829079 0.0937500116801711 no 3057 0.08879189116944 995 27261020
SGTC_1464 k208-0027 110 µM -1.34962420631795 0.0935237985056785 no 3058 0.0885682777680869 983 X1464
SGTC_37 0566-0070 1.56 µM -1.35015123600256 0.093438270489062 no 3059 0.0884837381801505 990 1626686
SGTC_2954 9074818 52.69 µM -1.35196669286886 0.0931440947773798 no 3060 0.0881929852557592 1008 16648742
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.35200498727882 0.0931378969500977 no 3061 0.0881868599263121 992 688788
SGTC_2694 st077685 81.9 µM -1.35203586623107 0.093132899512802 no 3062 0.0881819209571165 992 2838096
SGTC_2122 5258151 111.688 µM -1.35354780888653 0.0928884496530165 no 3063 0.0879403437071191 1007 2173356
SGTC_644 1498-1197 63.3 µM -1.35721494683555 0.092297520481684 no 3064 0.0873564614298426 1013 6741615
SGTC_110 0850-0284 111.64 µM -1.35731188694451 0.0922819372136835 no 3065 0.0873410659672362 963 3906265
SGTC_754 3474-0146 171 µM -1.35908099457128 0.0919978924546652 no 3066 0.0870604622755814 981 24762078
SGTC_990 3985-0011 41.3 µM -1.3593723634832 0.0919511729439196 no 3067 0.0870143119927188 990 5399565 YGL099W LSG1
SGTC_1336 1486-0901 104 µM -1.36121375359524 0.0916563218129956 no 3068 0.0867230745043925 992 5006114
SGTC_2510 benzyl isothiocyanate 8.31 µM -1.36805300345935 0.090567324599804 no 3069 0.0856477429088601 975 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2908 7930301 100 µM -1.37295841596777 0.089792183124011 no 3070 0.0848826373075355 996 2223178
SGTC_458 nppb 133 µM -1.37629634974558 0.0892675574754214 no 3071 0.0843649512851583 1014 4549 A chloride channel blocker.
SGTC_1456 k015-0012 13 µM -1.37702161976365 0.0891538684255308 no 3072 0.0842527818512981 1003 2989616
SGTC_1963 st076565 50.3 µM -1.37914169790593 0.0888221553474729 no 3073 0.0839255348201823 1022 4914280
SGTC_1040 k898-0338 155 µM -1.38638031815632 0.0876965064869301 no 3074 0.0828154015510739 1002 20969351
SGTC_2258 7960471 200 µM -1.38759794068503 0.0875082092136982 no 3075 0.0826297544453054 1026 2974708
SGTC_386 1509-0011 3.07 µM -1.38789730971586 0.0874619600178786 no 3076 0.0825841585925589 1001 3107280
SGTC_1160 4092-0570 10.5 µM -1.38916502776391 0.0872663138223789 no 3077 0.0823912867623059 1019 4994975
SGTC_2719 novobiocin 32.65 µM -1.39071284641393 0.0870278831088361 no 3078 0.0821562602487228 1019 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2341 7987486 176.74 µM -1.39247193350203 0.0867574990752965 no 3079 0.0818897674687587 993 1258686
SGTC_1207 2099-0101 141 µM -1.39602121186087 0.086213861957977 no 3080 0.0813540538139923 992 5837381
SGTC_3186 9110464 49.47 µM -1.39613342030232 0.0861967168210094 no 3081 0.0813371607392888 1010 17018021
SGTC_1292 0kpi-0043 232 µM -1.3965145693627 0.0861384973523056 no 3082 0.0812797981889961 1011 3333905
SGTC_1955 wogonin 32.4 µM -1.39653122171234 0.0861359544226246 no 3083 0.081277292723125 991 5281703 A flavanone.
SGTC_1562 morin hydrate 59.1 µM -1.39724078334771 0.0860276515942221 no 3084 0.0811705881945954 1001 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1550 gossypolone 36.6 µM -1.40005674660797 0.0855988458700698 no 3085 0.0807481630454756 1015 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_715 0868-0130 184 µM -1.40172375348015 0.0853457547557329 no 3086 0.0804988772934113 1031 2876258
SGTC_698 k064-0052 127 µM -1.40183115768312 0.0853294674971447 no 3087 0.0804828359273476 1047 5088751
SGTC_2285 7945142 200 µM -1.40620755924542 0.0846677889641843 no 3088 0.0798312500732405 1006 2970608
SGTC_850 0388-0143 75.9 µM -1.41061553906347 0.0840052334496406 no 3089 0.0791790036178458 1018 67273
SGTC_99 0109-0120 622.8 µM -1.41201773820139 0.0837952896865909 no 3090 0.0789723691623382 998 759414
SGTC_1257 0669-0121 16 µM -1.41785864256783 0.0829250010208115 no 3091 0.0781160195049385 997 4307855
SGTC_1708 st033234 31.827 µM -1.42457181990412 0.0819331631346741 no 3092 0.0771405053645025 1002 674664
SGTC_554 4483-2211 187 µM -1.42649827278919 0.0816501968593128 no 3093 0.0768622825594389 1029 747107
SGTC_210 3551-0445 56.827 µM -1.42769373391667 0.0814749728630219 no 3094 0.0766900152667543 1019 2865180 YOR207C RET1
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.43561065626981 0.0803217057070051 no 3095 0.0755565803825732 1015 16486 A toxic proline analog.
SGTC_2281 7943571 200 µM -1.43579997184534 0.0802942796957366 no 3096 0.0755296339227334 1015 1244024
SGTC_3257 9139206 32.98 µM -1.43636125536981 0.0802130085495553 no 3097 0.0754497859979488 1014 4910041
SGTC_565 1418-0001 44.5 µM -1.43795964311249 0.0799819103482937 no 3098 0.0752227525757141 1022 2862145
SGTC_1227 3909-8010 46.6 µM -1.43895444379249 0.0798383343884641 no 3099 0.0750817152504637 1019 15982272
SGTC_982 1491-0518 27.5 µM -1.44381770812891 0.0791392416900085 no 3100 0.0743951297353016 1013 3091256
SGTC_1174 0739-0097 51.1 µM -1.44551667203521 0.0788961118190286 no 3101 0.0741564067482202 1019 728447
SGTC_2638 epoxomicin 18 µM -1.44846913931103 0.0784749463018069 no 3102 0.0737429453757779 1007 9915668 A protesome inhibitor.
SGTC_1660 st012960 28.1 µM -1.44860057878624 0.0784562363412634 no 3103 0.0737245797394108 1010 24207266
SGTC_1393 3470-5649 58.2 µM -1.44889289954096 0.0784146376043571 no 3104 0.0736837471881628 1008 4108395
SGTC_3179 9107801 49.47 µM -1.45055553557529 0.0781783539896058 no 3105 0.0734518321628093 999 4818259
SGTC_771 0250-0039 27.3 µM -1.45092704278381 0.0781256315594676 no 3106 0.0734000883639118 1020 3005115
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.45345577957353 0.0777674823306271 no 3107 0.0730486244723311 1004 17037758
SGTC_1382 3002-2117 298 µM -1.45418656509834 0.0776642124211595 no 3108 0.0729472943719608 1043 1497314
SGTC_3242 9133940 49.47 µM -1.45808627504842 0.0771148898727187 no 3109 0.072408381991989 1015 17248444
SGTC_2074 5212007 75.395 µM -1.45897847658678 0.0769896282295422 no 3110 0.0722855158845001 1007 758611
SGTC_2556 citropten 84.59 µM -1.45919098192394 0.0769598161190449 no 3111 0.0722562751004325 1003 2775 A potential DNA crosslinker.
SGTC_244 nsc-207895 1.295 µM -1.45977803052366 0.0768775053998799 no 3112 0.0721755441859614 991 42640
SGTC_70 0141-0289 43.283 µM -1.45984642419147 0.0768679202040588 no 3113 0.0721661431880735 990 352408
SGTC_1306 1185-0270 9.02 µM -1.45995617756517 0.0768525404511691 no 3114 0.0721510590858773 1019 1548076
SGTC_1445 4239-0156 97.7 µM -1.46024729048991 0.0768117580954827 no 3115 0.0721110612966458 1035 4008346
SGTC_2108 5365811 200 µM -1.46109037449521 0.0766937422824584 no 3116 0.071995320707694 1000 780283
SGTC_757 1066-0008 322 µM -1.46516874030385 0.0761247943052001 no 3117 0.0714374429553384 1001 6842497
SGTC_1596 piperlongumine 63 µM -1.46942356013002 0.0755346606019875 no 3118 0.0708589704393853 996 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_988 1497-1057 103 µM -1.47242868163039 0.0751199622212143 no 3119 0.070452576348104 1018 3533044
SGTC_648 0375-0473 33.3 µM -1.47990284331206 0.0740960792285362 no 3120 0.0694495883976102 1022 1713139
SGTC_143 4032-1194 15.74 µM -1.48170839203232 0.0738503438115807 no 3121 0.0692089515802692 1016 1806963
SGTC_1815 st051655 58.2 µM -1.48327149497578 0.0736381087137084 no 3122 0.0690011462844687 1009 5984156
SGTC_2687 chenodiol 100 µM -1.48367071182475 0.0735839786487443 no 3123 0.0689481499384645 997 5702181 A cholesterol synthesis inhibitor.
SGTC_2078 5212016 200 µM -1.48378912331009 0.073567929012151 no 3124 0.0689324367568142 1020 1899708
SGTC_1015 4130-4525 82 µM -1.48830411873958 0.0729579557551982 no 3125 0.0683353546318068 1012 1363237
SGTC_1736 st036774 51 µM -1.48833041495938 0.0729544145247015 no 3126 0.0683318888351608 1003 1272247
SGTC_2195 6536160 144.242 µM -1.48856064314584 0.0729234160258897 no 3127 0.0683015509473216 1021 3834386
SGTC_2170 morpholine 200 µM -1.49303526506539 0.0723229420587759 no 3128 0.067713978027851 1026 121171 Reacts with secondary amines.
SGTC_2903 5923464 63.88 µM -1.49352333402915 0.072257675261396 no 3129 0.0676501254687967 1033 2876576
SGTC_2246 7293507 91.5585 µM -1.49508692102437 0.0720488892255242 no 3130 0.0674458793968429 1021 887656
SGTC_1619 st003326 88.7 µM -1.49565898135112 0.0719726175806984 no 3131 0.0673712722873459 962 2849032
SGTC_1061 3448-9325 110 µM -1.50040309040532 0.0713424787673217 no 3132 0.0667550097501543 1011 723482
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.5090313986269 0.0702072855693013 no 3133 0.0656453795058942 979 279621
SGTC_218 alverine citrate 93.75 µM -1.51217181025309 0.0697975797820378 no 3134 0.0652450801922665 1012 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_98 0074-0023 107.663 µM -1.51583143190247 0.0693224611230462 no 3135 0.0647809909899409 1031 3563821
SGTC_1811 st050069 61.5 µM -1.52258417457851 0.0684523156782233 no 3136 0.0639313857644936 1019 3877702
SGTC_1637 st007924 17.4 µM -1.52353308453464 0.0683307191869792 no 3137 0.0638126949834018 998 683336
SGTC_532 1548-0774 215 µM -1.52654185223221 0.0679462676021706 no 3138 0.0634374878617176 1049 5932993
SGTC_353 1988-1175 58.3 µM -1.52837269015403 0.0677131471657594 no 3139 0.063210015710847 996 2788357
SGTC_96 0929-0093 37.281 µM -1.53142534780209 0.0673258270935257 no 3140 0.0628321517142973 1023 6991579
SGTC_2250 alverine citrate 130 µM -1.53255433032671 0.0671830168116509 no 3141 0.0626928506960876 991 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1876 myriocin 605 nM -1.53511537109025 0.0668599271807932 no 3142 0.0623777456178366 1023 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2804 7954240 19.48 µM -1.53775368252688 0.0665283477922771 no 3143 0.0620544262084993 1018 828705
SGTC_2678 equilin 100 µM -1.53824333532916 0.0664669491813829 no 3144 0.0619945644219834 998 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1851 st056236 18.9 µM -1.53869868117776 0.0664098917673702 no 3145 0.0619389372273365 1007 5393171
SGTC_3139 9095020 49.47 µM -1.53877022945087 0.0664009298121188 no 3146 0.061930200095459 1000 25236292
SGTC_3203 9113543 49.47 µM -1.54004848120768 0.0662409769988486 no 3147 0.061774268162202 1019 17018012
SGTC_247 mechlorethamine 29.705 µM -1.54120546005964 0.066096456998008 no 3148 0.061633394530316 1016 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1508 1080-0625 72.9 µM -1.54143986634441 0.0660672067293574 no 3149 0.0616048838272364 987 767111
SGTC_1374 2889-5571 141 µM -1.54605356510166 0.0654935276507892 no 3150 0.0610458159566076 1006 2853281
SGTC_751 0833-0568 350 µM -1.54637811337525 0.065453318380411 no 3151 0.0610066383998872 1044 6954252
SGTC_675 1309-0189 238 µM -1.54663465604651 0.0654215480810666 no 3152 0.0609756839897246 1023 4246530
SGTC_3015 9080845 49.47 µM -1.5507273226385 0.0649163272696133 no 3153 0.060483521928758 1038 5296973
SGTC_830 4076-0286 57.8 µM -1.55230440713447 0.0647224538745615 no 3154 0.0602947019554665 1029 6866659
SGTC_2103 5378138 10 µM -1.55275775305147 0.0646668066569198 no 3155 0.0602405095623977 1022 244142
SGTC_853 0419-0306 21 µM -1.56265778717999 0.0634608424611128 no 3156 0.059066554142342 1032 762713
SGTC_567 1080-0542 68.4 µM -1.56733829822833 0.0628968183740738 no 3157 0.0585178189750024 1014 5950415
SGTC_341 1486-1430 230 µM -1.5753582548077 0.0619394635241807 no 3158 0.0575868872050203 1043 2054753 YPL210C SRP72
SGTC_544 k015-0020 52.4 µM -1.57560419048553 0.061910286514305 no 3159 0.0575585249004801 1030 3008304
SGTC_2087 5276107 200 µM -1.57895574344895 0.0615137374468706 no 3160 0.0571731043008231 1021 144405
SGTC_665 3914-0008 307 µM -1.5824999227622 0.0610965581532217 no 3161 0.0567677449674056 1039 1069549
SGTC_1247 0448-0043 5.84 µM -1.59147335071583 0.0600501973139793 no 3162 0.0557515441041806 1038 3089013 YGL099W LSG1
SGTC_1744 st037937 38.9 µM -1.59219554749902 0.0599665982991356 no 3163 0.055670386686396 1046 1016152
SGTC_3164 9100705 49.47 µM -1.59707828177552 0.0594037788310069 no 3164 0.0551241293377705 1018 17174235
SGTC_561 1550-0330 72.9 µM -1.60107549568232 0.0589461206265141 no 3165 0.0546800994258019 1036 6812934
SGTC_2311 7694451 200 µM -1.62041096991506 0.0567712595941427 no 3166 0.0525720124804608 1036 2163142
SGTC_1626 st003712 1.76 µM -1.62215894550805 0.0565778035321906 no 3167 0.0523846598041212 1028 24207035
SGTC_1166 k206-0078 225 µM -1.62353759493399 0.0564255891075345 no 3168 0.0522372667340564 1025 5404595
SGTC_2563 tomatine 8.54 µM -1.628164350995 0.055917114658803 no 3169 0.0517450207760488 1036 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1682 st012968 530 nM -1.62973701838189 0.0557451060569947 no 3170 0.0515785449849764 1016 24207270
SGTC_351 caspofungin 25 nM -1.63163113780218 0.0555384936054671 no 3171 0.0513786072971379 1032 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2683 piperine 63.03 µM -1.63611038176205 0.0550522982171529 no 3172 0.0509082438983437 1050 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_493 zm226600 134 µM -1.63982371645722 0.0546517925584936 no 3173 0.0505209127536203 1041 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2558 carylophyllene oxide 100 µM -1.64117227049672 0.0545069143737956 no 3174 0.0503808300515582 1049 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1118 chelidonine 707.474 nM -1.64179306093717 0.0544403236419283 no 3175 0.050316448804686 1043 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1821 st053465 65.6 µM -1.64613871639026 0.0539759755828239 no 3176 0.0498676014944722 1052 675086
SGTC_887 0885-0007 9.62 µM -1.64636766205961 0.0539515991735081 no 3177 0.0498440433543696 1050 5719458
SGTC_1921 5740136 50 µM -1.647317727434 0.0538505364850767 no 3178 0.0497463779986159 1023 1774243
SGTC_170 4197-0004 226 µM -1.64760698164347 0.0538197970103054 no 3179 0.0497166734172997 1033 218692
SGTC_914 3820-6779 408 µM -1.65578967706317 0.052955952288762 no 3180 0.0488822095103371 1031 2893481
SGTC_647 0140-0236 81 µM -1.65667491575901 0.0528631608544464 no 3181 0.0487926085412761 1056 990837
SGTC_1052 3253-3998 198 µM -1.66693207310232 0.051797377324262 no 3182 0.0477639562387838 1034 5450317
SGTC_1351 1496-0003 46.5 µM -1.66955134485807 0.0515279740653854 no 3183 0.0475040818539543 1052 3891978
SGTC_2943 9068529 45.32 µM -1.67246009604249 0.0512301036093892 no 3184 0.0472168151226431 1027 3270634
SGTC_2883 9059145 45.46 µM -1.67913571404871 0.0505516670985408 no 3185 0.0465627986233665 1051 16476510
SGTC_770 0389-1121 67.2 µM -1.68406299511258 0.0500555183945242 no 3186 0.0460847474769489 1054 6753108
SGTC_2008 4012253 172 µM -1.6852599784916 0.0499355771744615 no 3187 0.0459692118161402 1008 603940
SGTC_2172 5754775 163.918 µM -1.68850681470694 0.0496113885750566 no 3188 0.045656990960013 1030 2263357
SGTC_2259 7964009 200 µM -1.69671001620225 0.0487997985235591 no 3189 0.0448757490428068 1037 313134
SGTC_2463 5473429 200 µM -1.70377266102027 0.0481095820219319 no 3190 0.0442117836875487 1043 5399405
SGTC_1101 ebselen 5.29 µM -1.70504081378437 0.0479864795693567 no 3191 0.0440934063811251 1045 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2545 solidagenone 89.61 µM -1.71222451937118 0.0472938929976665 no 3192 0.0434276502548642 1026 6708572 An anti ulcer agent
SGTC_2722 naftopidil 47.16 µM -1.71631675667384 0.0469029530783725 no 3193 0.0430520415110622 1039 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1175 0741-0056 27.6 µM -1.71999849628503 0.0465534476559157 no 3194 0.0427163574596169 1053 765927
SGTC_2422 chlorphenesin carbamate 384.24 µM -1.72807362534115 0.0457941992810759 no 3195 0.0419875126806296 1038 2724 A muscle relaxant with antifungal properties.
SGTC_2962 9082311 13.18 µM -1.73826249083983 0.0448504461660017 no 3196 0.041082286205634 1047 16459453
SGTC_965 1291-5240 308 µM -1.74661097429566 0.0440888868690561 no 3197 0.0403524211400089 1050 2834598
SGTC_1232 0279-0259 161 µM -1.74814572309457 0.0439500262202424 no 3198 0.0402193986622984 1044 1560000
SGTC_1255 0566-0045 221 µM -1.75605529920821 0.0432399689137831 no 3199 0.0395394833617572 1035 2788469
SGTC_27 0485-0001 32.618 µM -1.7613198945415 0.0427725127553928 no 3200 0.0390921373306384 1025 2054479
SGTC_506 n9-isopropylolomoucine 153 µM -1.76153190450937 0.0427537737760835 no 3201 0.0390742089644327 1051 6610355
SGTC_901 1112-0062 60.1 µM -1.76258435509117 0.0426608487729764 no 3202 0.0389853088216311 1042 1908457
SGTC_3282 9108498 15.4605 µM -1.77250164083587 0.0417932085320373 no 3203 0.0381556615841594 1058 16459645
SGTC_1561 5-methoxyflavone 52.9 µM -1.77556393674661 0.0415282015951668 no 3204 0.0379024092527196 1026 94525
SGTC_2127 5253358 187.912 µM -1.78240758336931 0.0409408819176464 no 3205 0.0373413948802306 1054 20612
SGTC_2370 9071495 200 µM -1.78559532770963 0.0406696201143625 no 3206 0.0370824019832401 1050 21791103
SGTC_121 0557-0495 61.343 µM -1.79038730437055 0.0402645920186141 no 3207 0.036695834920834 1063 3104427
SGTC_3077 9117319 49.47 µM -1.79332713714183 0.0400177367550877 no 3208 0.036460315331633 1066 17154678
SGTC_1892 st058411 7.36 µM -1.79437781812815 0.0399298108303524 no 3209 0.0363764424780434 1060 3934738
SGTC_724 3910-0327 137 µM -1.79611876811986 0.0397844656269344 no 3210 0.0362378150797632 1057 2885483
SGTC_971 1315-0384 26.7 µM -1.79752888714437 0.039667055756178 no 3211 0.0361258481999045 1061 6769120
SGTC_3339 9145883 14.936 µM -1.80058893729162 0.0394132377371102 no 3212 0.0358838470597753 1015 2030670
SGTC_1730 st033808 45.1 µM -1.80403596151084 0.0391289060498444 no 3213 0.0356128347915829 1039 1045166
SGTC_2180 6301957 200 µM -1.80686077087425 0.0388971452447929 no 3214 0.0353919952291772 1043 845462
SGTC_186 3455-3465 67.277 µM -1.81451841443687 0.0382744942659243 no 3215 0.03479897517291 1039 755278
SGTC_2277 7947813 106.88 µM -1.81455100021702 0.0382718621507373 no 3216 0.034796469219246 1055 1246798
SGTC_2975 9084847 53.72 µM -1.81649747998699 0.0381149028452253 no 3217 0.0346470470769218 1052 27211724
SGTC_1853 st056710 91.2 µM -1.82212019642943 0.037664447781924 no 3218 0.0342183749456158 1054 269167
SGTC_208 k072-0098 12.366 µM -1.82280378108157 0.0376099809999145 no 3219 0.0341665574336365 1051 5948901
SGTC_1297 1068-0111 14.1 µM -1.82311632283304 0.03758509967272 no 3220 0.0341428874468405 1048 767057
SGTC_1024 4507-0395 26 µM -1.82493240913554 0.0374407875637089 no 3221 0.034005614888803 1061 4201836
SGTC_1843 st055809 45.5 µM -1.8253414597747 0.0374083455962107 no 3222 0.0339747586787375 1061 16413835
SGTC_2875 9039966 71.43 µM -1.82746264599399 0.0372404815264761 no 3223 0.0338151188154365 1057 6463691
SGTC_2449 5812982 45.77 µM -1.82898404054197 0.0371204625180397 no 3224 0.0337009995539132 1055 776185
SGTC_2749 bexarotene 57.39 µM -1.83304159165276 0.0368019175618144 no 3225 0.033398193047075 1039 82146 An retinoic acid receptor inhibitor.
SGTC_2334 9017922 200 µM -1.84201694851018 0.0361052299947356 no 3226 0.0327363353933378 1045 3163164
SGTC_3074 9116018 49.47 µM -1.8474238185095 0.0356907747652503 no 3227 0.0323428698917833 1067 17027303
SGTC_2921 7974240 10.71 µM -1.85023876351855 0.0354765477928108 no 3228 0.032139572132412 1047 2979074 YDR527W RBA50
SGTC_3194 9111903 49.47 µM -1.85551626702852 0.0350777531425986 no 3229 0.0317612692344979 1067 17087251
SGTC_1813 st051246 8.6015 µM -1.86729649758276 0.0342008414171752 no 3230 0.0309300971226556 1061 5291959
SGTC_373 0844-0104 25.9 µM -1.88134538571678 0.0331786967514971 no 3231 0.0299624754540722 1050 5375804
SGTC_589 1227-0070 34.1 µM -1.88533611033409 0.0328929797133282 no 3232 0.0296922369082284 1062 2841384
SGTC_2985 9022375 71.43 µM -1.8962716306028 0.0321204262596661 no 3233 0.0289620677945442 1051 4939335
SGTC_116 0155-0182 31.788 µM -1.89871679233983 0.0319497498214708 no 3234 0.0288008612346833 936 771486
SGTC_3235 9132602 49.47 µM -1.89922716649426 0.0319142194876791 no 3235 0.0287673071602835 1055 4912240
SGTC_3059 1327-0034 3 µM -1.90261412269286 0.0316792583276561 no 3236 0.0285454574908032 1051 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_57 miconazole 162.5 nM -1.90318347321451 0.0316399018241471 no 3237 0.0285083044410756 1032 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2397 5161689 200 µM -1.90559495073291 0.0314736555531211 no 3238 0.0283513888719055 1055 2259942
SGTC_2630 antimycin a 100 µM -1.90594975677443 0.0314492564188142 no 3239 0.0283283623051266 1054 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_3136 9095672 49.47 µM -1.91697351027015 0.030698936149996 no 3240 0.0276206485242908 1055 17217380
SGTC_571 k831-0106 44.2 µM -1.92900785243928 0.0298968169220239 no 3241 0.0268649437003861 1047 4783639
SGTC_1497 4476-2978 41.3 µM -1.93633801275385 0.0294168179394836 no 3242 0.0264131580132621 1055 1528379
SGTC_2525 harmine 47.85 µM -1.96239932587752 0.0277617809923311 no 3243 0.0248580055981629 1054 5280953 A monoamine oxidase inhibitor
SGTC_1000 4048-0884 8.67 µM -1.9634380339083 0.0276974587488588 no 3244 0.0247976490367139 1064 13040088
SGTC_131 0141-0277 33.849 µM -1.97733838190381 0.0268485637753552 no 3245 0.0240016969576331 1071 1547771
SGTC_2483 5729050 27.16 µM -1.98117041561958 0.0266183981105719 no 3246 0.0237860828649465 1059 2865180
SGTC_1111 tnp00062 510.699 nM -1.99297686149139 0.0259195996747822 no 3247 0.02313199042275 1062 676306
SGTC_367 0335-0881 7.1 µM -1.99433093733492 0.0258404449052522 no 3248 0.0230579502200768 1063 23828853
SGTC_2479 5617353 43.85 µM -2.00151460893664 0.0254238870322186 no 3249 0.0226684805114758 1053 2731746
SGTC_1860 st056228 74.6 µM -2.00600087470743 0.025166607121868 no 3250 0.0224280773366289 1066 688679
SGTC_759 3486-0358 89.3 µM -2.00792005415531 0.0250572136204352 no 3251 0.0223258938811023 1079 875103
SGTC_1386 3228-0095 33.8 µM -2.01223600599139 0.0248126592801824 no 3252 0.0220975323239263 1060 870181
SGTC_2849 9019321 12.99 µM -2.0125895148442 0.0247927174502875 no 3253 0.0220789154670894 1053 16489627
SGTC_2188 6126565 140.678 µM -2.01425918906079 0.0246987108633108 no 3254 0.0219911641547642 1063 874518
SGTC_1877 wortmannin 25 µM -2.02499443966927 0.0241014072231762 no 3255 0.0214339675928658 1070 312145 A covalent inhibitor of PI 3-kinase.
SGTC_229 benomyl 22.8748 µM -2.03362280673974 0.0236301689733653 no 3256 0.0209948202693073 1066 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_639 0833-0042 114 µM -2.03709791118134 0.0234425773371311 no 3257 0.0208201155963225 1074 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2892 9047358 58.44 µM -2.04720503233518 0.022904086933692 no 3258 0.0203189787733944 1069 6466771
SGTC_1640 st009078 66.4 µM -2.05475316971397 0.0225087650456157 no 3259 0.0199514257647719 1063 690618
SGTC_216 k038-0035 28.382 µM -2.05719839077353 0.0223819406578899 no 3260 0.0198335731428612 1073 4444231 YPR107C YTH1
SGTC_1555 citronellol 128 µM -2.05945697285369 0.0222653325300606 no 3261 0.0197252413981761 1075 8842 A terpine precursor.
SGTC_3036 9090181 49.47 µM -2.07356972302352 0.0215482564772183 no 3262 0.0190596447633165 1077 25236586
SGTC_663 1486-0733 13.9 µM -2.07616914794113 0.0214183298352205 no 3263 0.0189391548160619 1075 722445 YPR165W RHO1
SGTC_588 3970-1144 52.9 µM -2.07910093623624 0.0212725860688263 no 3264 0.0188040370382958 1069 1888707
SGTC_222 nsc-310342 10.666 µM -2.08389479837528 0.0210360828580353 no 3265 0.0185848688036266 1079 432556
SGTC_1895 st058434 18.3 µM -2.0904450281651 0.0207165300407907 no 3266 0.0182889208063863 1080 5393175
SGTC_2571 chrysanthemic acid 100 µM -2.09471283203549 0.0205105447697119 no 3267 0.018098263921261 1074 2743 An insecticide.
SGTC_2306 7482397 179.52 µM -2.09576428759279 0.0204600636037744 no 3268 0.0180515529045869 1078 891448
SGTC_1798 st045719 60.953 µM -2.10816059997338 0.0198728027202399 no 3269 0.0175085500297863 1061 3980186
SGTC_1969 st069479 40.1 µM -2.11135911342779 0.0197236194569043 no 3270 0.01737072829864 1067 3895485
SGTC_3337 9144342 33.5465 µM -2.13192076361752 0.0187871201606611 no 3271 0.0165066804840885 1069 17682949
SGTC_1323 1348-1351 11.2 µM -2.140795898776 0.0183947393824108 no 3272 0.0161452504254129 1078 6989654
SGTC_2653 dihydrofissinolide 100 µM -2.1462248267192 0.0181581775195272 no 3273 0.015927522876655 1081 6857746
SGTC_1791 st048313 56.1 µM -2.14861461180366 0.0180548690269389 no 3274 0.0158324812169301 1060 1204976
SGTC_280 3448-3607 3.04 µM -2.15708262187379 0.0176928277595619 no 3275 0.0154996136997227 1042 626179
SGTC_1795 st049545 62.3 µM -2.15827638905928 0.0176422910467434 no 3276 0.0154531746568047 1066 5291882
SGTC_1607 st000305 50.6 µM -2.15890303385009 0.0176158121276879 no 3277 0.0154288452296007 1075 5457690
SGTC_111 0083-0039 52.457 µM -2.1597617017532 0.0175795841438876 no 3278 0.0153955609340549 1072 759313
SGTC_1253 0550-0034 176 µM -2.17617633938422 0.0168991669441228 no 3279 0.0147710387057597 1073 5969915
SGTC_3048 9093155 49.47 µM -2.17939087319742 0.0167685890462166 no 3280 0.0146513217825451 1068 25236002
SGTC_2966 9084041 48.03 µM -2.18081980869458 0.0167108217882284 no 3281 0.0145983734184796 1072 17741380
SGTC_180 1486-1293 102.781 µM -2.18374667616667 0.0165930293240486 no 3282 0.014490433933851 1065 4140536
SGTC_1157 4092-0394 27.6 µM -2.20438826026263 0.0157823096124329 no 3283 0.0137485252919935 1078 3659885
SGTC_808 0711-0032 135 µM -2.20508832032157 0.0157554203883901 no 3284 0.0137239487548994 1080 4252555
SGTC_2781 5567276 71.43 µM -2.2099302167427 0.0155705173292521 no 3285 0.0135550028777055 1063 2853274
SGTC_2364 9055074 200 µM -2.22736808601208 0.014919947480311 no 3286 0.012961341759306 1069 6470630
SGTC_2431 5490079 200 µM -2.22739234034052 0.0149190591322132 no 3287 0.0129605319485931 1077 5722345
SGTC_1229 0139-0193 12.2 µM -2.22795189416216 0.0148985773273082 no 3288 0.0129418615425344 1067 3090752
SGTC_1410 3909-8106 77.9 µM -2.23484260207507 0.0146483265828543 no 3289 0.0127138419395235 1075 1039210
SGTC_1975 st070967 30.8 µM -2.24011646773776 0.014459246148948 no 3290 0.0125416813553584 1070 261391
SGTC_115 0527-0192 112.043 µM -2.24247634254204 0.0143753218659742 no 3291 0.0124653013111855 1077 4233931
SGTC_3021 9087658 49.47 µM -2.24725036510337 0.0142068250292476 no 3292 0.0123120155197536 1077 25237042
SGTC_2514 salinomycin 42.74 µM -2.25152321644021 0.0140574624263901 no 3293 0.0121762090668605 1080 23682228 A polyether potassium ionophore.
SGTC_2013 4024628 200 µM -2.25759595870679 0.0138475121251642 no 3294 0.0119854304218075 1071 5230760
SGTC_1706 st031321 9.9705 µM -2.25797330114852 0.0138345561328432 no 3295 0.01197366201111 1078 6103185
SGTC_3299 9121982 43.1275 µM -2.26734603202455 0.0135160830337441 no 3296 0.0116845477595352 1067 17594604 YPL160W CDC60
SGTC_3073 9114972 49.47 µM -2.26928761426623 0.0134509077438397 no 3297 0.0116254206207 1081 41905075
SGTC_453 enantio-paf c16 10 µM -2.28360120176989 0.0129787476435021 no 3298 0.011197489548325 1064 13871343 A lipid and platelet activating factor
SGTC_2217 6934799 96.0675 µM -2.30292238702729 0.0123641727388088 no 3299 0.0106416051601196 1080 675606
SGTC_482 fipronil 114 µM -2.32152282804624 0.0117965011854362 no 3300 0.0101293217550335 1089 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_380 3970-0968 6 µM -2.33517231390242 0.0113944470526163 no 3301 0.00976721042162077 1081 2891601
SGTC_1489 4065-0444 182 µM -2.3387112373918 0.0112921699253907 no 3302 0.00967519159214729 1080 2877968
SGTC_2273 7815444 169.05 µM -2.34783875781604 0.0110320537401179 no 3303 0.00944134681490341 1068 2824616
SGTC_520 3584-0023 682 µM -2.3479171287257 0.0110298430838826 no 3304 0.00943936056407087 1069 1340790
SGTC_2854 9024559 71.43 µM -2.35822834236147 0.0107423284140456 no 3305 0.00918119703941608 1059 3163529
SGTC_3307 9126885 69.2785 µM -2.36519342871688 0.0105518287735524 no 3306 0.00901032809580488 1083 24824909
SGTC_2146 5545642 200 µM -2.37993372852843 0.0101583540352599 no 3307 0.0086578759304627 1079 825326
SGTC_2448 5185112 27.17 µM -2.3821202958328 0.0101010900805643 no 3308 0.00860663668595305 1076 5718189
SGTC_843 0310-0051 143 µM -2.39963292314058 0.00965252659092376 no 3309 0.00820576006039638 1085 2065037
SGTC_3356 9151811 4.48 µM -2.41938987973102 0.00916746362374158 no 3310 0.00777328356944645 1086 1859254 YPR165W RHO1
SGTC_1692 fluoroquinolonic acid 71 µM -2.43628172463963 0.00876980199705709 no 3311 0.00741956112593632 1079 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1702 st027038 51 µM -2.44261604327754 0.00862462749681256 no 3312 0.00729062052417733 1088 5521182
SGTC_320 4092-0846 5.34 µM -2.45384258045818 0.00837250269326359 no 3313 0.00706694197889365 1071 1359356
SGTC_2712 st079126 47.7 µM -2.4558745800762 0.00832756634568352 no 3314 0.00702710989849833 1081 3152970
SGTC_898 1000-0849 28.3 µM -2.45968391737898 0.00824389570099148 no 3315 0.00695297135045856 1083 6751807
SGTC_446 go6976 132 µM -2.46440134503802 0.00814130330133154 no 3316 0.00686211695784818 1089 3501 A protein kinase C inhibitor.
SGTC_1863 st057641 20.1 µM -2.48200718770633 0.00776825936396941 no 3317 0.0065322320027292 1091 3921635
SGTC_1184 1269-1718 139 µM -2.51303662915737 0.00714728969232833 no 3318 0.00598484531143183 1085 5403821
SGTC_378 3970-0959 8.33 µM -2.52589474140006 0.00690307969630206 no 3319 0.00577020260185375 1087 6615653
SGTC_1808 st050063 61.5 µM -2.53069074362664 0.00681389522865774 no 3320 0.00569190848069277 1084 4011993
SGTC_1699 st031318 29.054 µM -2.54088767019353 0.00662765290242618 no 3321 0.0055285718682597 1083 5340658
SGTC_1454 4239-0054 42.6 µM -2.56972046716582 0.00612516314840181 no 3322 0.00508903027568082 1081 1340767
SGTC_1006 4099-6547 255 µM -2.57849502703224 0.0059790927209314 no 3323 0.00496158640244825 1081 3146833
SGTC_2302 7771753 200 µM -2.58253809823038 0.0059128331067061 no 3324 0.00490382664265398 1070 2203047
SGTC_2141 5621638 7.665 µM -2.60099388465589 0.00561857144161725 no 3325 0.0046477055487721 1085 2856238
SGTC_2684 capsaicin 100 µM -2.60452299483679 0.00556380768747145 no 3326 0.00460011235513175 1082 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_282 k297-0036 65.7 µM -2.64150409232586 0.00501783847028153 no 3327 0.00412694050085856 1082 5061378
SGTC_2481 5478948 45.16 µM -2.6522151417748 0.00486888192627312 no 3328 0.00399827855288342 1083 77792
SGTC_168 3970-0862 530.542 µM -2.69453071404393 0.00431821761007063 no 3329 0.0035243914924494 1073 3135186
SGTC_2137 5261020 140 µM -2.69532926601007 0.00430838393102865 no 3330 0.00351595524282236 1082 763655
SGTC_2190 6049624 200 µM -2.69601133784013 0.00430000048975611 no 3331 0.003508763903897 1085 2265554
SGTC_308 4092-1169 104 µM -2.72195730230394 0.00399172850682741 no 3332 0.00324482633568927 1088 2268590 YDL196W YDL196W
SGTC_3212 9128307 49.47 µM -2.7258360937427 0.0039473845606227 no 3333 0.00320694199775441 1073 27243542
SGTC_515 4092-1064 102 µM -2.74031329207147 0.003785746264023 no 3334 0.00306903224746833 1089 717353
SGTC_2634 4'-methoxyflavone 100 µM -2.7802649807313 0.00337002399855657 no 3335 0.0027157279330433 1085 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2143 5623677 140.463 µM -2.78490593260017 0.00332449410390288 no 3336 0.00267716269219975 1083 5375313
SGTC_3310 9130229 44.1445 µM -2.79859447787344 0.00319340670243193 no 3337 0.00256627758952269 1089 7761258
SGTC_25 0118-0223 35.662 µM -2.89133511856033 0.00242114786897832 no 3338 0.00191804412244124 1091 5333628
SGTC_321 4534-3890 65.3 µM -2.96131822047472 0.00195495711414762 no 3339 0.0015316262957389 1092 699746
SGTC_160 3453-0671 289.699 µM -2.96593744503799 0.0019272634672572 no 3340 0.00150880930315037 1087 5322268
SGTC_3348 9149464 3.537 µM -2.99710905832007 0.00174950916048129 no 3341 0.00136276594897804 1085 1951442
SGTC_1296 1068-0102 11.9 µM -3.00956325967091 0.0016827613632584 no 3342 0.00130811795219587 1093 767053
SGTC_217 ketoconazole 989 nM -3.02054562804072 0.00162583476739817 no 3343 0.00126159843886735 1083 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_104 0074-0074 590.992 µM -3.05636812897357 0.00145213140012507 no 3344 0.00112018002695567 1089 3943124
SGTC_3055 9094636 49.47 µM -3.0786179629293 0.00135294957450819 no 3345 0.00103981589528204 1087 25236176
SGTC_1922 5578187 25 µM -3.09980104562211 0.00126431433171709 no 3346 0.000968253361638761 1082 1350412
SGTC_2992 9074591 71.4286 µM -3.14381965628462 0.00109687995907835 no 3347 0.000833790876716402 1091 17741321
SGTC_3341 9147222 25.867 µM -3.20144194998206 0.000908401754860095 yes 3348 0.000683708122248071 1088 1939759
SGTC_591 4299-0174 154 µM -3.21562835020086 0.000866810885904599 yes 3349 0.000650796378229944 1093 5509088
SGTC_1725 st036284 20.55 µM -3.24367067861834 0.000789704551016477 yes 3350 0.000590000449906603 1086 707914
SGTC_603 3794-0023 45.9 µM -3.67671282503404 0.000171507209381659 yes 3351 0.000118129377070125 1095 3802260
SGTC_312 4092-0653 6.84 µM -3.86180724849974 8.48598545409326e-05 yes 3352 5.62756756855686e-05 1086 1148278
SGTC_969 1313-0238 134 µM -4.16091361580835 2.55097321212287e-05 yes 3353 1.58488487791729e-05 1094 5212874
SGTC_480 am 92016 50 µM -4.53860119541281 4.98366186890907e-06 yes 3354 2.83143092874465e-06 1094 2129 K+ channel blocker.
SGTC_2988 9073640 71.4286 µM -5.36678305395485 8.82281847080809e-08 yes 3355 4.00766849974116e-08 1094 9102229
SGTC_3052 9092717 49.47 µM -6.8367956248853 1.4566869759166e-11 yes 3356 4.04920721763114e-12 1095 25237534